diff --git a/interpro_active_site/advanced/idx2term.json b/interpro_active_site/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..9e26dfeeb6e641a33dae4961196235bdb965b21b --- /dev/null +++ b/interpro_active_site/advanced/idx2term.json @@ -0,0 +1 @@ +{} \ No newline at end of file diff --git a/interpro_active_site/basic/idx2term.json b/interpro_active_site/basic/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..884813dd16650df34831385d765007d0befa28c2 --- /dev/null +++ b/interpro_active_site/basic/idx2term.json @@ -0,0 +1 @@ +{"0": "Serine/threonine-protein kinase, active site [IPR008271]"} \ No newline at end of file diff --git a/interpro_active_site/basic/plot_0.png b/interpro_active_site/basic/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..2de6236dd28682d1b69f24bd9f8ae6dfb09dfae1 --- /dev/null +++ b/interpro_active_site/basic/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:8834f8986d47a1981db4403baec3ead989d9bec216cb4dee8cdb66100e03ef26 +size 157285 diff --git a/interpro_active_site/consensus.joblib b/interpro_active_site/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..6d5956ab42c44a1c702c130599e5af557bafc46d --- /dev/null +++ b/interpro_active_site/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:a76f37b8a100962d58e13688138b208fdac3c9c3ef17085ebdc41d062e35ae7d +size 75500 diff --git a/interpro_active_site/df_merge.tsv b/interpro_active_site/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..c57981107d970e936c6c67aa07afef8fff633223 --- /dev/null +++ b/interpro_active_site/df_merge.tsv @@ -0,0 +1 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 diff --git a/interpro_active_site/metrics.json b/interpro_active_site/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..df655d5e106694a3810ba4ee210a2b5584ba4b2b --- /dev/null +++ b/interpro_active_site/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2734, + "annotations_size": 55, + "title": "Average number of proteins per term", + "value": 2.4 +} \ No newline at end of file diff --git a/interpro_active_site/paths.json b/interpro_active_site/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..7a18a9dd8469e9a85c58e1931e4d67b997d4524e --- /dev/null +++ b/interpro_active_site/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/interpro_active_site/fragment/C166/C166_val_log2fc"} \ No newline at end of file diff --git a/interpro_active_site/result.tsv b/interpro_active_site/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..dff02d512f1cb4313fe35bbe581930cfa44fb830 --- /dev/null +++ b/interpro_active_site/result.tsv @@ -0,0 +1,2 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Serine/threonine-protein kinase, active site [IPR008271] 0.2712346724832289 0.1482245108517688 0.8821655886136517 1.0 0.8985019884027934 39 Q99640,P48729,P11802,P31751,P36507,Q13153,Q13555,Q13546 8 diff --git a/interpro_active_site/selections.json b/interpro_active_site/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..4f48acb148f07c2d34279499883b094a1486bd83 --- /dev/null +++ b/interpro_active_site/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["ATP-citrate lyase/succinyl-CoA ligase, active site [IPR017440]", "ATP:guanido phosphotransferase active site [IPR022415]", "ATPase, alpha/beta subunit, nucleotide-binding domain, active site [IPR020003]", "Adenosine/AMP deaminase active site [IPR006650]", "Adenylosuccinate synthase, active site [IPR033128]", "Beta-ketoacyl synthase, active site [IPR018201]", "Citrate synthase active site [IPR019810]", "ClpP, Ser active site [IPR018215]", "ClpP, histidine active site [IPR033135]", "Cysteine peptidase, asparagine active site [IPR025661]", "Cysteine peptidase, cysteine active site [IPR000169]", "Cysteine peptidase, histidine active site [IPR025660]", "DNA methylase, C-5 cytosine-specific, active site [IPR018117]", "DNA topoisomerase I, active site [IPR018521]", "Ferrochelatase, active site [IPR019772]", "Glucose-6-phosphate dehydrogenase, active site [IPR019796]", "Glyceraldehyde 3-phosphate dehydrogenase, active site [IPR020830]", "Glycoside hydrolase, family 2, active site [IPR023232]", "Glycosyl hydrolases family 31, active site [IPR030458]", "Histidine acid phosphatase active site [IPR033379]", "Hydroxymethylglutaryl-CoA lyase, active site [IPR000138]", "Hydroxymethylglutaryl-coenzyme A synthase, active site [IPR000590]", "L-lactate dehydrogenase, active site [IPR018177]", "Leu/Phe/Val dehydrogenases active site [IPR033524]", "Malate dehydrogenase, active site [IPR001252]", "Nucleoside diphosphate kinase, active site [IPR023005]", "Orotidine 5'-phosphate decarboxylase, active site [IPR018089]", "Peptidase S16, active site [IPR008268]", "Peptidase S26A, signal peptidase I, serine active site [IPR019756]", "Peptidase S8, subtilisin, His-active site [IPR022398]", "Peptidase S8, subtilisin, Ser-active site [IPR023828]", "Peptidase S9, serine active site [IPR002471]", "Peptidase family C14A, His active site [IPR016129]", "Peptidase family C14A, cysteine active site [IPR033139]", "Phosphoglycerate/bisphosphoglycerate mutase, active site [IPR001345]", "Phosphoribosylglycinamide formyltransferase, active site [IPR001555]", "Protein-tyrosine phosphatase, active site [IPR016130]", "Pyridine nucleotide-disulphide oxidoreductase, class I, active site [IPR012999]", "Pyruvate kinase, active site [IPR018209]", "Ribonuclease T2, His active site 1 [IPR018188]", "Ribonuclease T2, His active site 2 [IPR033130]", "Ribonucleotide reductase small subunit, acitve site [IPR030475]", "Serine carboxypeptidase, serine active site [IPR018202]", "Serine carboxypeptidases, histidine active site [IPR033124]", "Serine/threonine-protein kinase, active site [IPR008271]", "Thermonuclease active site [IPR002071]", "Thiolase, active site [IPR020610]", "Thiolase, acyl-enzyme intermediate active site [IPR020615]", "Thymidylate synthase, active site [IPR020940]", "Transaldolase, active site [IPR018225]", "Triosephosphate isomerase, active site [IPR020861]", "Tyrosine-protein kinase, active site [IPR008266]", "Ubiquitin-activating enzyme E1, Cys active site [IPR033127]", "Ubiquitin-conjugating enzyme, active site [IPR023313]", "Uracil-DNA glycosylase, active site [IPR018085]"], "available_proteins": ["ACAA2", "ACAT1", "ACAT2", "ACLY", "ACP2", "ACP6", "ADA", "ADSS", "AKT2", "APEH", "ATP5A1", "ATP5B", "ATP6V1A", "ATP6V1B2", "AURKA", "BLMH", "BUB1", "CAMK2G", "CAPN1", "CASP3", "CASP6", "CASP7", "CASP8", "CDK1", "CDK12", "CDK2", "CDK4", "CDK6", "CHEK2", "CKB", "CKMT1A*", "CLPP", "CPVL", "CS", "CSK", "CSNK1A1", "CSNK2A2", "CTSA", "CTSC", "DLD", "DNMT1", "DUSP3", "EIF2AK2", "FASN", "FECH", "G6PD", "GAA", "GANAB", "GAPDH", "GART", "GLUD1", "GSK3A", "GSK3B", "GSR", "GUSB", "HADHB", "HMGCL", "HMGCS1", "LDHA", "LDHB", "LONP1", "MAP2K1", "MAP2K2", "MAP2K3", "MAPK1", "MASTL", "MDH1", "MDH2", "NEK9", "NME1", "NME2", "PAK1", "PAK2", "PASK", "PBK", "PGAM1", "PKM", "PKMYT1", "PKN1", "PKN2", "PLK1", "PREP", "PRKACA", "PRPF4B", "PTK7", "PTPN1", "RIPK1", "RNASET2", "ROCK2", "RPS6KA1", "RPS6KA3", "RRM2", "SCP2", "SCPEP1", "SEC11A", "SLK", "SND1", "SRPK1", "SUCLG1", "TALDO1", "TIGAR", "TOP1", "TPI1", "TPP2", "TXNRD1", "TYMS", "UBA1", "UBA2", "UBA3", "UBE2G2", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2S", "UMPS", "UNG", "VRK1", "WNK1"], "leading_proteins": ["AKT2", "CAMK2G", "CDK4", "CSNK1A1", "MAP2K2", "PAK1", "PKMYT1", "RIPK1"]} \ No newline at end of file diff --git a/interpro_binding_site/advanced/idx2term.json b/interpro_binding_site/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..9e26dfeeb6e641a33dae4961196235bdb965b21b --- /dev/null +++ b/interpro_binding_site/advanced/idx2term.json @@ -0,0 +1 @@ +{} \ No newline at end of file diff --git a/interpro_binding_site/basic/idx2term.json b/interpro_binding_site/basic/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..73c30eb04cc7ed44e0e71d59c90648406a898b8d --- /dev/null +++ b/interpro_binding_site/basic/idx2term.json @@ -0,0 +1 @@ +{"0": "EF-Hand 1, calcium-binding site [IPR018247]", "1": "Protein kinase, ATP binding site [IPR017441]"} \ No newline at end of file diff --git a/interpro_binding_site/basic/plot_0.png b/interpro_binding_site/basic/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..de4fec9ceaa6460076e4d2f139d0d3eb37e0414d --- /dev/null +++ b/interpro_binding_site/basic/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:d86a675aa9c6ea9bd2110dd4d7e9f40e06ab0b09ea058074f804b5b7f568ea96 +size 141435 diff --git a/interpro_binding_site/basic/plot_1.png b/interpro_binding_site/basic/plot_1.png new file mode 100644 index 0000000000000000000000000000000000000000..26eec60fb769501bdebfc3a63605d9dfff111c96 --- /dev/null +++ b/interpro_binding_site/basic/plot_1.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:1e4c5d607267eeea9413a21c10639002945b8f177b40b5abdc241ffd3d795a4c +size 155293 diff --git a/interpro_binding_site/consensus.joblib b/interpro_binding_site/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..03bf9636f2b0fb96b4321cffe223448010099e6e --- /dev/null +++ b/interpro_binding_site/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:1ed249d56eb47694d77ec8711d5a9e8d0821328958d81d959679b2087e8293da +size 67969 diff --git a/interpro_binding_site/df_merge.tsv b/interpro_binding_site/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..c57981107d970e936c6c67aa07afef8fff633223 --- /dev/null +++ b/interpro_binding_site/df_merge.tsv @@ -0,0 +1 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 diff --git a/interpro_binding_site/metrics.json b/interpro_binding_site/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..53f3525f12ba8cee4d246de205299cf26d338f12 --- /dev/null +++ b/interpro_binding_site/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2734, + "annotations_size": 31, + "title": "Average number of proteins per term", + "value": 4.032258064516129 +} \ No newline at end of file diff --git a/interpro_binding_site/paths.json b/interpro_binding_site/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..e3bad58edabe6d4d551911d19b1bc1fd976a8769 --- /dev/null +++ b/interpro_binding_site/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/interpro_binding_site/fragment/C166/C166_val_log2fc"} \ No newline at end of file diff --git a/interpro_binding_site/result.tsv b/interpro_binding_site/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..e779244f80014fe01152606a2a3be8dffb7b41b4 --- /dev/null +++ b/interpro_binding_site/result.tsv @@ -0,0 +1,5 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Peptidase M16, zinc-binding site [IPR001431] 0.6727732219171231 1.1494727683273092 0.2503610893558792 0.9998680480697816 0.3233830737513439 5 O43847,Q10713 2 +EF-Hand 1, calcium-binding site [IPR018247] 0.3736362119161628 1.0946561105677162 0.2736673234461002 0.9999504318092416 0.3393474810731643 36 O95202,O43852,P80303,Q14257,Q9NWM8,Q9BRK5,Q02818,Q9Y680 8 +Aminotransferase, class-II, pyridoxal-phosphate binding site [IPR001917] 0.4293557833089378 0.6204655753385755 0.5349513113163102 0.999999999950745 0.5718445052001937 2 O75600 1 +Protein kinase, ATP binding site [IPR017441] 0.2687953586682606 0.1191928619149973 0.9051225617019276 1.0 0.9352933137586584 35 Q99640,P48729,P11802,P31751,P36507,Q13153,Q13555 7 diff --git a/interpro_binding_site/selections.json b/interpro_binding_site/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..ce28cbf50876346678a97a29fe702e9a4b9f887e --- /dev/null +++ b/interpro_binding_site/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["2-oxo acid dehydrogenase, lipoyl-binding site [IPR003016]", "2Fe-2S ferredoxin, iron-sulphur binding site [IPR006058]", "6-phosphogluconate-binding site [IPR006184]", "AP endonuclease 1, binding site [IPR020847]", "APOBEC/CMP deaminase, zinc-binding [IPR016192]", "Aconitase family, 4Fe-4S cluster binding site [IPR018136]", "Adenylosuccinate synthase, GTP-binding site [IPR018220]", "Adrenodoxin, iron-sulphur binding site [IPR018298]", "Aminotransferase class-V, pyridoxal-phosphate binding site [IPR020578]", "Aminotransferase, class-II, pyridoxal-phosphate binding site [IPR001917]", "Aminotransferases, class-I, pyridoxal-phosphate-binding site [IPR004838]", "Beta tubulin, autoregulation binding site [IPR013838]", "Biotin-binding site [IPR001882]", "Copper centre Cu(A) [IPR001505]", "Cytochrome b5, heme-binding site [IPR018506]", "Cytochrome c oxidase, subunit Vb, zinc binding site [IPR020893]", "EF-Hand 1, calcium-binding site [IPR018247]", "Fumarate reductase/succinate dehydrogenase, FAD-binding site [IPR003952]", "Hexokinase, binding site [IPR019807]", "IQ motif, EF-hand binding site [IPR000048]", "Inositol monophosphatase, metal-binding site [IPR020583]", "Manganese/iron superoxide dismutase, binding site [IPR019833]", "PPM-type phosphatase, divalent cation binding [IPR000222]", "Peptidase M16, zinc-binding site [IPR001431]", "Peptidase M24A, methionine aminopeptidase, subfamily 2, binding site [IPR018349]", "Porphobilinogen deaminase, dipyrromethane cofactor binding site [IPR022419]", "Protein kinase, ATP binding site [IPR017441]", "RNA polymerases, subunit N, zinc binding site [IPR020789]", "Serine hydroxymethyltransferase, pyridoxal phosphate binding site [IPR019798]", "Sigma-54 interaction domain, ATP-binding site 1 [IPR025662]", "Transketolase binding site [IPR020826]"], "available_proteins": ["ACACA", "ACO1", "ACO2", "ACTN1", "ACTN4", "ADSS", "AKT2", "APEX1", "AURKA", "BPNT1", "BUB1", "CALM3", "CALU", "CAMK2G", "CAPN1", "CAPNS1", "CDK1", "CDK12", "CDK2", "CDK4", "CDK6", "CETN2", "COX2", "COX5B", "CSK", "CSNK1A1", "CSNK2A2", "CYB5B", "DCTD", "DLAT", "DLST", "DST", "EHD1", "EHD4", "EIF2AK2", "EPS15", "EPS15L1", "FDX1", "FKBP10", "FKBP14", "FKBP7", "GCAT", "GOT1", "GOT2", "GPD2", "GSK3A", "GSK3B", "HK1", "HK2", "HMBS", "IDE", "ILKAP", "IQGAP1", "LETM1", "MACF1", "MAP2K1", "MAP2K2", "MAP2K3", "MAPK1", "MAPK14", "MCCC1", "MICU1", "MYH10", "MYH14", "MYH9", "MYO1B", "MYO1D", "NFS1", "NRDC", "NUCB1", "NUCB2", "PA2G4", "PAK1", "PAK2", "PASK", "PC", "PCCA", "PDCD6", "PEF1", "PGD", "PKMYT1", "PKN1", "PKN2", "PLCG1", "PLK1", "PLS3", "PMPCA", "PMPCB", "POLR2L", "PPM1G", "PRKACA", "PRKCSH", "PSAT1", "RAB18", "RCN1", "RCN2", "REPS1", "RHOT1", "ROCK2", "RPS6KA1", "RPS6KA3", "S100A11", "SDF4", "SDHA", "SDHB", "SHMT1", "SHMT2", "SLC25A12", "SLC25A24", "SLK", "SOD2", "SPTAN1", "SPTLC2", "SRI", "SRPK1", "STK4", "TKT", "TUBB", "TUBB2A", "TUBB2B", "TUBB4A", "TUBB4B", "TUBB6", "UQCRC2", "VRK1"], "leading_proteins": ["AKT2", "CALU", "CAMK2G", "CDK4", "CSNK1A1", "FKBP14", "FKBP7", "GCAT", "LETM1", "MAP2K2", "NRDC", "NUCB1", "NUCB2", "PAK1", "PKMYT1", "PMPCA", "RCN2", "SDF4"]} \ No newline at end of file diff --git a/interpro_conserved_site/advanced/idx2term.json b/interpro_conserved_site/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..9e26dfeeb6e641a33dae4961196235bdb965b21b --- /dev/null +++ b/interpro_conserved_site/advanced/idx2term.json @@ -0,0 +1 @@ +{} \ No newline at end of file diff --git a/interpro_conserved_site/basic/idx2term.json b/interpro_conserved_site/basic/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..09bcc3f73ef6f58b4171038b2be25f1579cdbc67 --- /dev/null +++ b/interpro_conserved_site/basic/idx2term.json @@ -0,0 +1 @@ +{"0": "Intermediate filament protein, conserved site [IPR018039]", "1": "Zinc finger, RING-type, conserved site [IPR017907]", "2": "Mini-chromosome maintenance, conserved site [IPR018525]"} \ No newline at end of file diff --git a/interpro_conserved_site/basic/plot_0.png b/interpro_conserved_site/basic/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..3467f88961daa7c3594fea1b81a4ddc8a30104fb --- /dev/null +++ b/interpro_conserved_site/basic/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:edbce4ac09f48cbf824a8c6e1f83bf8c353fb9d7dc5527307ebf1e006fc24fcc +size 138501 diff --git a/interpro_conserved_site/basic/plot_1.png b/interpro_conserved_site/basic/plot_1.png new file mode 100644 index 0000000000000000000000000000000000000000..df793347f15f44a3fa525a76c1d1d525f0b7a23e --- /dev/null +++ b/interpro_conserved_site/basic/plot_1.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:33a5173e1f634df2f7d1bb04a3dcd1eda901d63998877624e45fe3447027c669 +size 151023 diff --git a/interpro_conserved_site/basic/plot_2.png b/interpro_conserved_site/basic/plot_2.png new file mode 100644 index 0000000000000000000000000000000000000000..0f1b65b2b3718f70329a2a859d65d1407c8e5dc8 --- /dev/null +++ b/interpro_conserved_site/basic/plot_2.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:47e4cb67db765b392e0c061bf3e063bdedd586f44440746e4c0786d087ffc741 +size 148255 diff --git a/interpro_conserved_site/consensus.joblib b/interpro_conserved_site/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..791245d72c0be310ba09136c1c11062b815f1466 --- /dev/null +++ b/interpro_conserved_site/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:0d46bd0db0da8d5b0552250c9827e065ff2e75f007e7d0060574f5e47f049817 +size 123390 diff --git a/interpro_conserved_site/df_merge.tsv b/interpro_conserved_site/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..c57981107d970e936c6c67aa07afef8fff633223 --- /dev/null +++ b/interpro_conserved_site/df_merge.tsv @@ -0,0 +1 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 diff --git a/interpro_conserved_site/metrics.json b/interpro_conserved_site/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..ff90da5ef51461a5f62bb2866f082d4a171f5c63 --- /dev/null +++ b/interpro_conserved_site/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2734, + "annotations_size": 264, + "title": "Average number of proteins per term", + "value": 2.496212121212121 +} \ No newline at end of file diff --git a/interpro_conserved_site/paths.json b/interpro_conserved_site/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..58b1add8cb03158bca7d95362e81a4a56b938d5a --- /dev/null +++ b/interpro_conserved_site/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/interpro_conserved_site/fragment/C166/C166_val_log2fc"} \ No newline at end of file diff --git a/interpro_conserved_site/result.tsv b/interpro_conserved_site/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..5c5586f6a740dd95787a752d377a3f2718c67f92 --- /dev/null +++ b/interpro_conserved_site/result.tsv @@ -0,0 +1,24 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Haem oxygenase conserved site [IPR018207] 0.9344802342606168 3.1344566453683047 0.0017217269368705 0.3655061308784072 0.007102123614591 2 P30519 1 +Tetraspanin, conserved site [IPR018503] 0.9213030746705726 3.075395732778736 0.002102234182352 0.4262571630440162 0.0082834302110586 2 O60637 1 +Sterol reductase, conserved site [IPR018083] 0.91617862371889 3.052315331275125 0.0022708340994908 0.4512881931307207 0.0085642886037938 2 Q14739 1 +3-hydroxyacyl-CoA dehydrogenase, conserved site [IPR006180] 0.8744509516837496 2.861994325338233 0.0042098444434641 0.6716729054020447 0.0126295333303925 2 Q16836 1 +Glycoside hydrolase, family 29, conserved site [IPR018526] 0.7902635431918014 2.464707866294726 0.0137125000276316 0.9738824970012928 0.0325041304678697 2 Q9BTY2 1 +Dynamin, GTPase region, conserved site [IPR019762] 0.7895314787701322 2.4611735345235535 0.0138483365831767 0.9748151211401868 0.0325041304678697 2 P50570 1 +Sugar transporter, conserved site [IPR005829] 0.7877013177159644 2.4523316546789267 0.0141933775588873 0.9770376109754716 0.0325830580482284 2 P11166 1 +Guanylate kinase, conserved site [IPR020590] 0.8824175824175827 2.036968221707832 0.0416532266481579 0.999986756925211 0.0723450778625901 4 O14936,Q9NZW5,Q14168 3 +Intermediate filament protein, conserved site [IPR018039] 0.7558698621372664 1.8674818765152923 0.0618343253969935 0.9999999519383912 0.0954274953935921 8 Q16352,P07196,P48681,P07197,P08670 5 +Quinone oxidoreductase/zeta-crystallin, conserved site [IPR002364] 0.8403592287619716 1.8650638200873444 0.0621724591200676 0.9999999563014176 0.0954274953935921 4 Q8N4Q0,Q8WWV3 2 +Mitogen-activated protein (MAP) kinase, conserved site [IPR003527] 0.650805270863837 1.767149974070075 0.077203115090187 0.999999999386216 0.1107696868685292 2 P28482 1 +Syntaxin/epimorphin, conserved site [IPR006012] 0.8150183150183157 1.7602126210195197 0.0783717628469282 0.9999999995607376 0.1118386237383192 4 Q9P2W9,O15400,Q13190 3 +IMP dehydrogenase / GMP reductase, conserved site [IPR015875] 0.637628111273795 1.6989239879322937 0.0893335065886797 0.9999999999813418 0.1242481013501381 2 P20839 1 +Proteasome beta-type subunit, conserved site [IPR016050] 0.7166008400392367 1.682614586666947 0.0924497260690775 0.9999999999924516 0.1271183733449816 8 Q99436,P28070,P28072,P49721 4 +Mrp, conserved site [IPR000808] 0.5527086383601807 1.253284082974449 0.2101023389981524 1.0 0.2616368749788313 2 Q9Y5Y2 1 +GTP1/OBG, conserved site [IPR006074] 0.5223279648609146 1.0932141441783785 0.274299788293709 1.0 0.3337103415186137 2 Q9Y295 1 +Histidine triad, conserved site [IPR019808] 0.5197657393850657 1.0797591008800076 0.2802494681963385 1.0 0.3378349753599697 2 Q9BX68 1 +Oxysterol-binding protein, conserved site [IPR018494] 0.6416312435260497 1.0167422581624548 0.309276057200115 1.0 0.3694519416327165 5 Q9BZF3 1 +ABC transporter-like, conserved site [IPR017871] 0.5449778691646638 0.7818028871852637 0.4343304240181598 1.0 0.4921168752823784 7 P08183,O75027 2 +AMP-binding, conserved site [IPR020845] 0.4831011642729539 0.3989544296971501 0.6899267823454094 1.0 0.7464781579474922 4 O60488 1 +Zinc finger, RING-type, conserved site [IPR017907] 0.3587013881993146 0.2471350192129269 0.8048037326963347 1.0 0.8397951993353057 12 O75150,P14373,O15164,Q14527,Q9UBS8,Q9UPQ4,Q9UPN9,P19474,Q5VTR2,Q96T88 10 +Enoyl-CoA hydratase/isomerase, conserved site [IPR018376] 0.4107866498708949 0.1636456911241944 0.8700100732221292 1.0 0.8868056344812436 5 Q13011 1 +Mini-chromosome maintenance, conserved site [IPR018525] 0.3907624633431089 0.1482615861781141 0.8821363300490748 1.0 0.8957076582036759 6 P49736,Q14566,P25205,P33993,P33992 5 diff --git a/interpro_conserved_site/selections.json b/interpro_conserved_site/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..4087c747c5a759ed4639da992e47415e42ba56ac --- /dev/null +++ b/interpro_conserved_site/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["14-3-3 protein, conserved site [IPR023409]", "3-hydroxyacyl-CoA dehydrogenase, conserved site [IPR006180]", "3-hydroxyisobutyrate dehydrogenase-related, conserved site [IPR002204]", "4Fe-4S ferredoxin, iron-sulphur binding, conserved site [IPR017900]", "ABC transporter-like, conserved site [IPR017871]", "AMP-binding, conserved site [IPR020845]", "AP endonuclease 1, conserved site [IPR020848]", "AT hook, DNA-binding motif [IPR017956]", "ATP synthase, F1 complex, gamma subunit conserved site [IPR023632]", "ATP-citrate lyase/succinyl-CoA ligase, conserved site [IPR033847]", "ATP-dependent RNA helicase DEAD-box, conserved site [IPR000629]", "ATPase, AAA-type, conserved site [IPR003960]", "ATPase, OSCP/delta subunit, conserved site [IPR020781]", "Acin1, RNSP1-SAP18 binding (RSB) motif [IPR032552]", "Actin, conserved site [IPR004001]", "Actin/actin-like conserved site [IPR020902]", "Actinin-type actin-binding domain, conserved site [IPR001589]", "Acyl-CoA dehydrogenase, conserved site [IPR006089]", "Acyl-CoA-binding protein, ACBP, conserved site [IPR022408]", "Adenylate kinase, conserved site [IPR033690]", "Alanine dehydrogenase/NAD(P) transhydrogenase, conserved site-1 [IPR008142]", "Alanine dehydrogenase/pyridine nucleotide transhydrogenase, conserved site-2 [IPR008143]", "Alcohol dehydrogenase, zinc-type, conserved site [IPR002328]", "Aldehyde dehydrogenase, cysteine active site [IPR016160]", "Aldehyde dehydrogenase, glutamic acid active site [IPR029510]", "Aldo/keto reductase, conserved site [IPR018170]", "Alpha-D-phosphohexomutase, conserved site [IPR016066]", "Aminoacyl-tRNA synthetase, class I, conserved site [IPR001412]", "Amyloidogenic glycoprotein, copper-binding domain conserved site [IPR019744]", "Amyloidogenic glycoprotein, intracellular domain, conserved site [IPR019745]", "Annexin repeat, conserved site [IPR018252]", "Apoptosis regulator, Bcl-2, BH1 motif, conserved site [IPR020717]", "Apoptosis regulator, Bcl-2, BH2 motif, conserved site [IPR020726]", "Apoptosis regulator, Bcl-2, BH3 motif, conserved site [IPR020728]", "ArgE/DapE/ACY1/CPG2/YscS, conserved site [IPR001261]", "BUD31/G10-related, conserved site [IPR018230]", "Bacterial Fmu (Sun)/eukaryotic nucleolar NOL1/Nop2p, conserved site [IPR018314]", "Band 7/stomatin-like, conserved site [IPR018080]", "Bromodomain, conserved site [IPR018359]", "C-type lectin, conserved site [IPR018378]", "CAP, conserved site, C-terminal [IPR028417]", "CAP, conserved site, N-terminal [IPR018106]", "CBX family C-terminal motif [IPR033773]", "Cadherin conserved site [IPR020894]", "Calreticulin/calnexin, conserved site [IPR018124]", "Carbohydrate/purine kinase, PfkB, conserved site [IPR002173]", "Chaperonin Cpn60, conserved site [IPR018370]", "Chaperonin GroES, conserved site [IPR018369]", "Chaperonin TCP-1, conserved site [IPR002194]", "Chromo domain, conserved site [IPR023779]", "Clathrin adaptor complex, small chain [IPR000804]", "Clathrin adaptor, mu subunit, conserved site [IPR018240]", "Coproporphyrinogen III oxidase, conserved site [IPR018375]", "Cullin, conserved site [IPR016157]", "Cyclic nucleotide-binding, conserved site [IPR018488]", "Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site [IPR020892]", "Cytochrome P450, conserved site [IPR017972]", "D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site 1 [IPR029752]", "D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site [IPR029753]", "DNA ligase, ATP-dependent, conserved site [IPR016059]", "DNA methylase, C-5 cytosine-specific, conserved site [IPR031303]", "DNA topoisomerase, type IIA, conserved site [IPR018522]", "DNA-directed DNA polymerase, family B, conserved site [IPR017964]", "DNA-directed RNA polymerase, 30-40kDa subunit, conserved site [IPR001514]", "DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site [IPR002464]", "Dihydrofolate reductase conserved site [IPR017925]", "Dihydroorotase, conserved site [IPR002195]", "DnaJ domain, conserved site [IPR018253]", "Dynamin, GTPase region, conserved site [IPR019762]", "Dynein light chain, type 1/2, conserved site [IPR019763]", "EGF-like calcium-binding, conserved site [IPR018097]", "EGF-like, conserved site [IPR013032]", "Electron transfer flavoprotein subunit alpha, conserved site [IPR018206]", "Electron transfer flavoprotein, beta-subunit, conserved site [IPR000049]", "Enolase, conserved site [IPR020809]", "Enoyl-CoA hydratase/isomerase, conserved site [IPR018376]", "Eukaryotic translation initiation factor 4E (eIF-4E), conserved site [IPR019770]", "F-actin capping protein, alpha subunit, conserved site [IPR017865]", "F-actin capping protein, beta subunit, conserved site [IPR019771]", "FERM conserved site [IPR019747]", "FLAP/GST2/LTC4S, conserved site [IPR018295]", "Fatty acid desaturase type 1, conserved site [IPR001522]", "Fibrillarin, conserved site [IPR020813]", "Fork head domain conserved site 2 [IPR030456]", "Fork head domain conserved site1 [IPR018122]", "Formate-tetrahydrofolate ligase, FTHFS, conserved site [IPR020628]", "Fructose-bisphosphate aldolase class-I active site [IPR029768]", "Fumarate lyase, conserved site [IPR020557]", "GHMP kinase, ATP-binding, conserved site [IPR006203]", "GTP1/OBG, conserved site [IPR006074]", "Galactokinase, conserved site [IPR019741]", "Gamma-glutamyl phosphate reductase GPR, conserved site [IPR020593]", "Glucosamine-6-phosphate isomerase, conserved site [IPR018321]", "Glutamate 5-kinase, conserved site [IPR019797]", "Glutamyl-tRNA(Gln) amidotransferase, subunit B, conserved site [IPR017958]", "Glutathione peroxidase conserved site [IPR029760]", "Glycoside hydrolase family 27/36, conserved site [IPR000111]", "Glycoside hydrolase, family 2, conserved site [IPR023230]", "Glycoside hydrolase, family 29, conserved site [IPR018526]", "Glycoside hydrolase, family 35, conserved site [IPR019801]", "Glycosyl hydrolases family 31, conserved site [IPR030459]", "Glyoxalase I, conserved site [IPR018146]", "Guanylate kinase, conserved site [IPR020590]", "HIND motif [IPR045347]", "HMG box A DNA-binding domain, conserved site [IPR017967]", "HMG-I/HMG-Y, DNA-binding, conserved site [IPR000637]", "Haem oxygenase conserved site [IPR018207]", "Heat shock protein 70, conserved site [IPR018181]", "Heat shock protein Hsp90, conserved site [IPR019805]", "Helix-hairpin-helix motif, class 2 [IPR008918]", "Helix-turn-helix motif [IPR000047]", "Hexapeptide transferase, conserved site [IPR018357]", "Histidine triad, conserved site [IPR019808]", "Histone H2A conserved site [IPR032458]", "Histone H4, conserved site [IPR019809]", "Homeobox, conserved site [IPR017970]", "IMP dehydrogenase / GMP reductase, conserved site [IPR015875]", "Immunoglobulin/major histocompatibility complex, conserved site [IPR003006]", "Inositol monophosphatase, conserved site [IPR020550]", "Intermediate filament protein, conserved site [IPR018039]", "Isocitrate/isopropylmalate dehydrogenase, conserved site [IPR019818]", "Kinesin motor domain, conserved site [IPR019821]", "Lipocalin family conserved site [IPR022272]", "Low-density lipoprotein (LDL) receptor class A, conserved site [IPR023415]", "Lysosome-associated membrane glycoprotein, conserved site [IPR018134]", "Macrophage migration inhibitory factor, conserved site [IPR019829]", "Malic enzyme, conserved site [IPR015884]", "Mini-chromosome maintenance, conserved site [IPR018525]", "Mitogen-activated protein (MAP) kinase, conserved site [IPR003527]", "Molybdenum cofactor biosynthesis, conserved site [IPR008284]", "Mrp, conserved site [IPR000808]", "Myristoyl-CoA:protein N-myristoyltransferase, conserved site [IPR022678]", "NADH:ubiquinone oxidoreductase, 30kDa subunit, conserved site [IPR020396]", "NADH:ubiquinone oxidoreductase, 49kDa subunit, conserved site [IPR014029]", "NADH:ubiquinone oxidoreductase, 51kDa subunit, conserved site [IPR001949]", "NADH:ubiquinone oxidoreductase, 75kDa subunit, conserved site [IPR000283]", "NUDIX hydrolase, conserved site [IPR020084]", "Oxysterol-binding protein, conserved site [IPR018494]", "P-type trefoil, conserved site [IPR017957]", "Peptidase M22, conserved site [IPR017860]", "Peptidase M24B, X-Pro dipeptidase/aminopeptidase P, conserved site [IPR001131]", "Peptidase S26A, signal peptidase I, conserved site [IPR019758]", "Peptidyl-prolyl cis-trans isomerase, PpiC-type, conserved site [IPR023058]", "Phosphatidylethanolamine-binding, conserved site [IPR001858]", "Phosphatidylinositol 3/4-kinase, conserved site [IPR018936]", "Phosphoenolpyruvate carboxykinase, GTP-utilising, conserved site [IPR018091]", "Phosphofructokinase, conserved site [IPR015912]", "Phosphoglucose isomerase, conserved site [IPR018189]", "Phosphoglycerate kinase, conserved site [IPR015911]", "Phosphomannose isomerase, type I, conserved site [IPR018050]", "Phosphoribosyl pyrophosphate synthetase, conserved site [IPR000842]", "Phosphoribosylglycinamide synthetase, conserved site [IPR020559]", "Phosphorylase pyridoxal-phosphate attachment site [IPR035090]", "Polyamine biosynthesis domain, conserved site [IPR030373]", "Polyprenyl synthetase, conserved site [IPR033749]", "Procollagen-lysine 5-dioxygenase, conserved site [IPR001006]", "Profilin conserved site [IPR027310]", "Proliferating cell nuclear antigen, PCNA, conserved site [IPR022659]", "Proteasome beta-type subunit, conserved site [IPR016050]", "Protein phosphatase 2A regulatory subunit PR55, conserved site [IPR018067]", "Proteinase inhibitor I2, Kunitz, conserved site [IPR020901]", "Proteinase inhibitor I25, cystatin, conserved site [IPR018073]", "Pseudouridine synthase TruD, conserved site [IPR020119]", "Purine phosphorylase, family 2, conserved site [IPR018099]", "Quinone oxidoreductase/zeta-crystallin, conserved site [IPR002364]", "RNA 3'-terminal phosphate cyclase-like, conserved site [IPR020719]", "RNA polymerase, beta subunit, conserved site [IPR007121]", "RNA polymerase, subunit H/Rpb5, conserved site [IPR020608]", "Ras GTPase-activating protein, conserved site [IPR023152]", "Rel homology domain, conserved site [IPR030492]", "Retro-transposon transporting motif [IPR018892]", "Ribonuclease II/R, conserved site [IPR022966]", "Ribosomal S11, conserved site [IPR018102]", "Ribosomal S24e conserved site [IPR018098]", "Ribosomal protein L1, conserved site [IPR023673]", "Ribosomal protein L10e, conserved site [IPR018255]", "Ribosomal protein L11, conserved site [IPR020785]", "Ribosomal protein L13, conserved site [IPR023563]", "Ribosomal protein L13e, conserved site [IPR018256]", "Ribosomal protein L14P, conserved site [IPR019972]", "Ribosomal protein L15, conserved site [IPR001196]", "Ribosomal protein L15e, conserved site [IPR020925]", "Ribosomal protein L18e, conserved site [IPR021132]", "Ribosomal protein L19/L19e conserved site [IPR023638]", "Ribosomal protein L2, conserved site [IPR022671]", "Ribosomal protein L21e, conserved site [IPR018259]", "Ribosomal protein L22/L17, conserved site [IPR018260]", "Ribosomal protein L23/L25, conserved site [IPR001014]", "Ribosomal protein L24e, conserved site [IPR023442]", "Ribosomal protein L27e, conserved site [IPR018262]", "Ribosomal protein L29, conserved site [IPR018254]", "Ribosomal protein L3, conserved site [IPR019926]", "Ribosomal protein L30, conserved site [IPR018038]", "Ribosomal protein L30e, conserved site [IPR022991]", "Ribosomal protein L31e, conserved site [IPR020052]", "Ribosomal protein L32e, conserved site [IPR018263]", "Ribosomal protein L34e, conserved site [IPR018065]", "Ribosomal protein L35Ae, conserved site [IPR018266]", "Ribosomal protein L37e, conserved site [IPR018267]", "Ribosomal protein L4/L1e, eukaryotic/archaeal, conserved site [IPR013000]", "Ribosomal protein L5, conserved site [IPR020929]", "Ribosomal protein L6, conserved site-2 [IPR002359]", "Ribosomal protein L7Ae conserved site [IPR004037]", "Ribosomal protein S10, conserved site [IPR018268]", "Ribosomal protein S13, conserved site [IPR018269]", "Ribosomal protein S17, conserved site [IPR019979]", "Ribosomal protein S17e, conserved site [IPR018273]", "Ribosomal protein S19 conserved site [IPR020934]", "Ribosomal protein S19e, conserved site [IPR018277]", "Ribosomal protein S2, conserved site [IPR018130]", "Ribosomal protein S21e, conserved site [IPR018279]", "Ribosomal protein S28e conserved site [IPR028626]", "Ribosomal protein S3, conserved site [IPR018280]", "Ribosomal protein S3Ae, conserved site [IPR018281]", "Ribosomal protein S4, conserved site [IPR018079]", "Ribosomal protein S4e, N-terminal, conserved site [IPR018199]", "Ribosomal protein S5, N-terminal, conserved site [IPR018192]", "Ribosomal protein S6e, conserved site [IPR018282]", "Ribosomal protein S7, conserved site [IPR020606]", "Ribosomal protein S8e, conserved site [IPR018283]", "Ribosomal protein S9, conserved site [IPR020574]", "Ribosome maturation protein SBDS, conserved site [IPR018023]", "RidA, conserved site [IPR019897]", "S-adenosyl-L-homocysteine hydrolase, conserved site [IPR020082]", "S-adenosylmethionine synthetase, conserved site [IPR022631]", "S100/Calbindin-D9k, conserved site [IPR001751]", "SAICAR synthetase, conserved site [IPR018236]", "SecY conserved site [IPR030659]", "Serpin, conserved site [IPR023795]", "Short-chain dehydrogenase/reductase, conserved site [IPR020904]", "Sodium:dicarboxylate symporter, conserved site [IPR018107]", "Squalene/phytoene synthase, conserved site [IPR019845]", "Stathmin, conserved site [IPR030514]", "Sterol reductase, conserved site [IPR018083]", "Succinyl-CoA synthetase, beta subunit, conserved site [IPR017866]", "Sugar transporter, conserved site [IPR005829]", "Sulfatase, conserved site [IPR024607]", "Syntaxin/epimorphin, conserved site [IPR006012]", "TPP-binding enzyme, conserved site [IPR000399]", "Terpene synthase, conserved site [IPR002365]", "Tetrahydrofolate dehydrogenase/cyclohydrolase, conserved site [IPR020867]", "Tetraspanin, conserved site [IPR018503]", "Thiolase, conserved site [IPR020613]", "Thioredoxin, conserved site [IPR017937]", "Thiosulphate sulfurtransferase, conserved site [IPR001307]", "Thymidine kinase, conserved site [IPR020633]", "Thymidylate kinase, conserved site [IPR018095]", "Tr-type G domain, conserved site [IPR031157]", "Transcription factor TFIIB, conserved site [IPR023486]", "Translation elongation factor EF1B, beta/delta chains, conserved site [IPR001326]", "Translation elongation factor Ts, conserved site [IPR018101]", "Translationally controlled tumour protein, conserved site [IPR018103]", "Tubulin, conserved site [IPR017975]", "UbiE/COQ5 methyltransferase, conserved site [IPR023576]", "Ubiquitin conserved site [IPR019954]", "Ubiquitin interacting motif [IPR003903]", "Ubiquitin specific protease, conserved site [IPR018200]", "Ubiquitin-activating enzyme E1, conserved site [IPR018074]", "Vinculin, conserved site [IPR000633]", "WD40 repeat, conserved site [IPR019775]", "XPG conserved site [IPR019974]", "YgfZ/GcvT conserved site [IPR017703]", "Zinc finger, PHD-type, conserved site [IPR019786]", "Zinc finger, RING-type, conserved site [IPR017907]"], "available_proteins": ["AAAS", "ABCB1", "ABCB10", "ABCB7", "ABCD3", "ABCE1", "ABCF1", "ABCF2", "ACAA2", "ACAD9", "ACADM", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACBD5", "ACIN1", "ACLY", "ACSL1", "ACSL3", "ACSL4", "ACTN1", "ACTN2", "ACTN4", "ACTR1A", "ACTR2", "ACTR3", "ADH5", "ADK", "ADSL", "AFG3L2", "AHCY", "AHCYL1", "AK1", "AK2", "AK4", "AKR1A1", "AKR1B1", "ALDH18A1", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ANXA1", "ANXA11", "ANXA2", "ANXA6", "ANXA7", "AP1M1", "AP2M1", "AP2S1", "AP3M1", "APEX1", "APP", "ATAD1", "ATP5C1", "ATP5O", "BAG6", "BAK1", "BAZ1A", "BAZ1B", "BCS1L", "BDH2", "BOP1", "BPNT1", "BPTF", "BRD4", "BUD31", "CAD", "CALR", "CANX", "CAP1", "CAPZA1", "CAPZB", "CASK", "CBR1", "CBX1", "CBX3", "CBX5", "CBX8", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CDC40", "CDX2", "CETN2", "CHAF1B", "CHD1", "CHD4", "CLGN", "CMPK1", "CNDP2", "COLEC12", "COPA", "COPZ1", "CORO1B", "CORO1C", "CPOX", "CRYZ", "CSTB", "CSTF1", "CTBP1", "CTBP2", "CTNNA1", "CUL1", "CUL2", "CUL3", "CUL4A", "CUL4B", "CUL5", "CYP51A1", "DCAF13", "DCAF7", "DCPS", "DCXR", "DDT", "DDX10", "DDX17", "DDX18", "DDX20", "DDX23", "DDX24", "DDX27", "DDX3X", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX51", "DDX54", "DDX55", "DDX6", "DHCR7", "DHFR", "DHRS7B", "DHX15", "DHX16", "DHX30", "DHX36", "DHX38", "DHX8", "DHX9", "DIDO1", "DIS3", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC2", "DNAJC9", "DNM1L", "DNM2", "DNMT1", "DRG1", "DRG2", "DSG2", "DST", "DTL", "DTYMK", "DYNLL1", "DYNLL2", "EARS2", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "EEF1A2", "EEF1B2", "EEF1D", "EEF2", "EIF3I", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4E", "ENO1", "EPB41", "EPB41L2", "EPB41L3", "EPRS", "EPS15", "ERCC2", "ETFA", "ETFB", "EXO1", "EZR", "FBL", "FDFT1", "FDPS", "FEN1", "FH", "FLNA", "FLNB", "FLNC", "FOXC1", "FUCA1", "FUCA2", "GAA", "GALK1", "GANAB", "GART", "GATB", "GCDH", "GEMIN5", "GFM1", "GLA", "GLB1", "GLO1", "GMPPA", "GMPPB", "GNPDA1", "GNS", "GPHN", "GPI", "GPX8", "GRHPR", "GRWD1", "GSPT1", "GTF2B", "GTF3C2", "GUSB", "H2AFX", "H4C1*", "HADH", "HADHA", "HADHB", "HGS", "HIBADH", "HINT2", "HLA-A", "HLA-B", "HLTF", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMOX1", "HMOX2", "HSD17B10", "HSD17B12", "HSD17B4", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA14", "HSPA1B", "HSPA2", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPD1", "HSPE1", "HSPH1", "HYOU1", "IARS", "IARS2", "IBA57", "IDH1", "IDH2", "IDH3A", "IDH3B", "ILVBL", "IMPDH1", "IMPDH2", "INA", "IQGAP1", "IVD", "KDM2A", "KDSR", "KIF11", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF3A", "KIF4A", "KIF5B", "KIFC1", "LAMP1", "LAMP2", "LARS", "LARS2", "LBR", "LDLR", "LIG1", "LIG3", "LMNA", "LMNB1", "LMNB2", "LSS", "MACF1", "MAPK1", "MAPK14", "MARS", "MAT2A", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "ME2", "MGST2", "MID1", "MIF", "MPI", "MPP1", "MPP2", "MPP6", "MPST", "MRC2", "MRPS2", "MRPS5", "MRPS9", "MSN", "MTAP", "MTHFD1", "MTHFD1L", "MTHFD2", "MTOR", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS8", "NDUFV1", "NEFL", "NEFM", "NES", "NFKB1", "NKTR", "NLE1", "NMT1", "NNT", "NOP2", "NSD2", "NSF", "NUBP2", "NUBPL", "NUDT1", "NUDT5", "NUP153", "NUP37", "NVL", "OSBP", "OSBPL11", "OSBPL6", "OSBPL8", "OSBPL9", "OSGEP", "P4HB", "PAFAH1B1", "PAICS", "PAK1IP1", "PBRM1", "PCK2", "PCNA", "PDIA3", "PDIA4", "PDIA6", "PEBP1", "PEPD", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGK1", "PGM1", "PGM2", "PHF8", "PHGDH", "PI4KB", "PIK3C3", "PIN1", "PLEC", "PLOD1", "PLOD2", "PLOD3", "PLRG1", "PLS3", "PNP", "POLA1", "POLD1", "POLR1B", "POLR1C", "POLR2B", "POLR2C", "POLR2E", "PPIB", "PPID", "PPIE", "PPIF", "PPIH", "PPIL1", "PPP2R2A", "PRKAR1A", "PRKAR2A", "PRKDC", "PRPF19", "PRPF4", "PRPS2", "PSMA4", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD4", "PUS7", "PWP1", "PWP2", "PYGB", "PYGL", "QARS", "QDPR", "RACK1", "RAE1", "RANBP2", "RARS", "RARS2", "RCL1", "RDH13", "RDX", "RIDA", "RNF14", "RNF20", "RNF40", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL15", "RPL17", "RPL18", "RPL19", "RPL21", "RPL23", "RPL23A", "RPL24", "RPL27", "RPL27A", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL37", "RPL4", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPS11", "RPS14", "RPS15", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS24", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS8", "RPS9", "RPSA", "RRP8", "RSF1", "RTN4IP1", "S100A10", "S100A11", "SART1", "SBDS", "SCD", "SCP2", "SDHB", "SEC11A", "SEC61A1", "SERPINB6", "SERPINH1", "SLC1A5", "SLC27A4", "SLC2A1", "SLIT2", "SMARCA4", "SMU1", "SNRNP40", "SNU13", "SORD", "SPATA5L1", "SPTBN1", "SPTBN2", "SRM", "STAM", "STMN1", "STOM", "STRN", "STX12", "STX18", "STX5", "STX7", "SUCLA2", "SUCLG1", "SUCLG2", "SV2A", "SYNE2", "TBL3", "TCP1", "THOC6", "TK1", "TLN1", "TMX1", "TMX3", "TMX4", "TOP2A", "TOP2B", "TPT1", "TRIM21", "TRIM24", "TRIM25", "TRIM27", "TRIM28", "TRIM33", "TRIM35", "TRIP13", "TSFM", "TSPAN3", "TSPAN6", "TTF2", "TUBB", "TUBB2A", "TUBB2B", "TUBB4A", "TUBB4B", "TUBB6", "TUFM", "TXNDC12", "TXNDC5", "TXNL1", "UBA1", "UBA2", "UBFD1", "UHRF1", "USP10", "USP11", "USP14", "USP15", "USP47", "USP48", "USP5", "USP7", "USP9X", "UTP15", "UTP18", "UTRN", "VARS1", "VARS2", "VAT1", "VCL", "VCP", "VIM", "VPS4B", "WARS", "WDHD1", "WDR1", "WDR18", "WDR3", "WDR36", "WDR41", "WDR5", "WDR61", "WDR77", "XPNPEP1", "YARS2", "YME1L1", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2"], "leading_proteins": ["ABCB1", "ABCB7", "ACSL4", "CASK", "DNM2", "DRG1", "ECH1", "FUCA2", "HADH", "HINT2", "HLTF", "HMOX2", "IMPDH1", "INA", "LBR", "MAPK1", "MCM2", "MCM3", "MCM5", "MCM6", "MCM7", "MPP2", "MPP6", "NEFL", "NEFM", "NES", "NUBP2", "OSBPL6", "PSMB2", "PSMB4", 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a/interpro_domain/df_merge.tsv b/interpro_domain/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..09e0d91cbdc97fa2d789a14edf57e69100639a7f --- /dev/null +++ b/interpro_domain/df_merge.tsv @@ -0,0 +1,6 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +RNA recognition motif domain [IPR000504] 47 115 2.9070156649615795 0.0036489492412328 39.713592233009706 116.0 0.2316956716939257 0.5316884276370477 13.873754985119357 5.729331786381952 1.713447249572458 0.3950212299678106 0.0013045100247433 1.0 0.8195646169006738 1.0199156994074962e-06 4.376670445801541e-13 +Aminopeptidase N-like , N-terminal domain [IPR045357] 2 5 1.982702643867416 0.0474006541036418 2.121359223300971 5.466019417475728 1.4317001483019938 0.1783942022754649 1.021530403905949 0.5881604361499402 0.986353205880356 0.2226891741813114 0.0003127091156062 0.0006219606051344 0.0025156479029566 0.0007187465088185 0.0053637976870067 +Peptidase M1, membrane alanine aminopeptidase [IPR014782] 2 5 1.982702643867416 0.0474006541036418 2.121359223300971 5.466019417475728 1.4317001483019938 0.1783942022754649 1.021530403905949 0.5881604361499402 0.986353205880356 0.2226891741813114 0.0003127091156062 0.0006219606051344 0.0025156479029566 0.0007187465088185 0.0053637976870067 +Guanylate kinase/L-type calcium channel beta subunit [IPR008145] 3 5 1.978061186580195 0.0479218045014471 2.9975728155339807 6.963592233009709 0.5006632403339694 0.4738825144563896 2.043814711463587 1.6869386038453082 0.907662015536667 0.3076020117251588 0.041818515662187 1.0 1.0 0.0693365470158766 0.0098879726868235 +Guanylate kinase-like domain [IPR008144] 3 5 1.978061186580195 0.0479218045014471 2.9975728155339807 6.963592233009709 0.5006632403339694 0.4738825144563896 2.043814711463587 1.6869386038453082 0.907662015536667 0.3076020117251588 0.0297379856574316 1.0 1.0 0.0498779046475234 0.0049531384619904 diff --git a/interpro_domain/metrics.json b/interpro_domain/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..8a04d6b17dde1307ae95782f519f6c1abeec3d9a --- /dev/null +++ b/interpro_domain/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2734, + "annotations_size": 2335, + "title": "Average number of proteins per term", + "value": 2.091648822269807 +} \ No newline at end of file diff --git a/interpro_domain/paths.json b/interpro_domain/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..65074e3fcb15de600e5da659942cd2c45b1ad97b --- /dev/null +++ b/interpro_domain/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/interpro_domain/fragment/C166/C166_val_log2fc"} \ No newline at end of file diff --git a/interpro_domain/result.tsv b/interpro_domain/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..f800e409007a03148960390f4a82221c386ee93c --- /dev/null +++ b/interpro_domain/result.tsv @@ -0,0 +1,184 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Metaxin, glutathione S-transferase domain [IPR033468] 0.9795021961932656 3.3331720487736956 0.0008586182917225 0.8654386317915143 0.0034096491686599 2 Q13505 1 +Mitochondrial outer membrane transport complex Sam37/metaxin, N-terminal domain [IPR019564] 0.9795021961932656 3.3331720487736956 0.0008586182917225 0.8654386317915143 0.0034096491686599 2 Q13505 1 +EXPERA domain [IPR033118] 0.9619326500732072 3.256183517322716 0.001129207397039 0.9285093840886168 0.0042322620739745 2 Q15125 1 +Endoplasmic reticulum vesicle transporter, C-terminal [IPR012936] 0.9553440702781858 3.227129615766365 0.0012503880519882 0.946146235785342 0.0045126060299732 2 Q9Y282 1 +Endoplasmic reticulum vesicle transporter, N-terminal [IPR039542] 0.9553440702781858 3.227129615766365 0.0012503880519882 0.946146235785342 0.0045126060299732 2 Q9Y282 1 +Heterogeneous nuclear ribonucleoprotein Q acidic domain [IPR041337] 0.9447291361639828 3.180107967640672 0.0014722018933504 0.9679393007553626 0.005130733464139 2 O60506 1 +Acyl-CoA oxidase, C-terminal [IPR002655] 0.9399707174231352 3.15894353998777 0.0015834216270593 0.9752819065929296 0.0053817896640227 2 O15254 1 +Sam68, tyrosine-rich domain [IPR032335] 0.9143484626647144 3.044057003678251 0.0023341090882487 0.9957315958295236 0.0072209487285474 2 O75525 1 +KHDRBS, Qua1 domain [IPR032571] 0.9143484626647144 3.044057003678251 0.0023341090882487 0.9957315958295236 0.0072209487285474 2 O75525 1 +Complex 1 LYR protein domain [IPR008011] 0.899341142020498 2.9760325195757904 0.0029200389615993 0.9989172652197458 0.0083969100681458 2 Q9NU23 1 +Potentiating neddylation domain [IPR005176] 0.8920204978038082 2.9426504424856192 0.003254156293456 0.9995049466939508 0.0091437484298674 2 Q92564 1 +CARG-binding factor, N-terminal [IPR012956] 0.8894582723279678 2.930935617176559 0.0033794281258985 0.9996308576677256 0.0093494842108685 2 Q99729 1 +RNA recognition motif domain [IPR000504] 0.430414565964125 2.9070156649615795 0.0036489492412328 0.9998037025529648 0.0097934442279064 115 Q12849,P52272,O60506,Q9Y6M1,P98175,Q01844,O43390,Q9BQ04,Q9UHX1,Q9P2K5,P23246,P84103,Q99729,P35637,P08621,P52597,P23588,P14866,Q14103,Q13151,P55795,P09651,P62995,Q96PK6,Q96EP5,P22626,P51991,P38159,Q92804,P31942,Q9BWF3,O43347,Q9P2N5,Q93062,O14979,Q13242,Q07955,Q01085,P31943,Q15287,P98179,P43243,P07910,Q8IY67,Q13595,Q15233,P31483 47 +Far upstream element-binding protein, C-terminal [IPR015096] 0.8832357247437773 2.9024179137743404 0.0037029418939007 0.999827034335276 0.0098853496153544 2 Q92945 1 +3-hydroxyacyl-CoA dehydrogenase, C-terminal [IPR006108] 0.8744509516837496 2.861994325338233 0.0042098444434641 0.9999472916351214 0.0108021832697679 2 Q16836 1 +3-hydroxyacyl-CoA dehydrogenase, NAD binding [IPR006176] 0.8744509516837496 2.861994325338233 0.0042098444434641 0.9999472916351214 0.0108021832697679 2 Q16836 1 +GMP phosphodiesterase, delta subunit [IPR008015] 0.9835225192237278 2.8576574323671364 0.0042678086510765 0.9999539903299784 0.0109388948411238 3 A6NIH7,O43924 2 +ATPase family AAA domain-containing protein 3, N-terminal [IPR021911] 0.870058565153736 2.841710500903071 0.0044872217932263 0.9999724977089668 0.0114135761298295 2 Q5T9A4 1 +Phospholipase D/Transphosphatidylase [IPR001736] 0.8612737920937056 2.8009980608944978 0.0050944825149417 0.9999933840091598 0.0125085348815866 2 Q8IV08 1 +Fatty acid hydroxylase [IPR006694] 0.8539531478770164 2.76692289565357 0.0056588137213089 0.9999982411626558 0.0135928910019262 2 Q15800 1 +Marvel domain [IPR008253] 0.833455344070283 2.6707908055931906 0.0075672791277012 0.9999999801843013 0.0169978648041804 2 O43760 1 +TRAM/LAG1/CLN8 homology domain [IPR006634] 0.9362870743317464 2.6613422455403235 0.0077829802252118 0.9999999880716628 0.0173574582864084 3 Q96G23,P27544 2 +Zinc finger, CHHC-type [IPR012996] 0.9340900768949104 2.6521015593358936 0.0079992477094867 0.999999992829928 0.0178227513374538 3 P31943,P52597 2 +ERAP1-like C-terminal domain [IPR024571] 0.925031226170825 2.6138955797568753 0.0089516390333792 0.999999999238852 0.0195529252974186 3 P55786 1 +Syntaxin, N-terminal domain [IPR006011] 0.8144216691068805 2.580565587372103 0.0098638617388593 0.9999999999113622 0.0212082110131091 2 O15400 1 +Gamma tubulin complex component protein, N-terminal [IPR041470] 0.8111273792093757 2.564855321067748 0.0103218834425529 0.9999999999699106 0.02189064290496 2 Q9BSJ2 1 +Gamma tubulin complex component, C-terminal [IPR040457] 0.8111273792093757 2.564855321067748 0.0103218834425529 0.9999999999699106 0.02189064290496 2 Q9BSJ2 1 +RBM4, RNA recognition motif 2 [IPR034898] 0.8023426061493475 2.522824728788913 0.0116416409247688 0.9999999999986658 0.0240664699247148 2 Q9BWF3 1 +RBM4, RNA recognition motif 1 [IPR034897] 0.8023426061493475 2.522824728788913 0.0116416409247688 0.9999999999986658 0.0240664699247148 2 Q9BWF3 1 +L27 domain, C-terminal [IPR014775] 0.9025997803002564 2.5185671380792853 0.0117833416712702 0.9999999999990454 0.0242415002664458 3 O14936,Q14168 2 +L27 domain [IPR004172] 0.9025997803002564 2.5185671380792853 0.0117833416712702 0.9999999999990454 0.0242415002664458 3 O14936,Q14168 2 +Zinc finger C2H2 AKAP95-type [IPR034736] 0.8945441230318565 2.4840801381691984 0.0129886574424598 0.9999999999999448 0.0262130640692684 3 Q5BKZ1,Q9ULX6 2 +Alpha-L-fucosidase, C-terminal [IPR031919] 0.7902635431918014 2.464707866294726 0.0137125000276316 0.99999999999999 0.0271973344049297 2 Q9BTY2 1 +Dynamin stalk domain [IPR000375] 0.7895314787701322 2.4611735345235535 0.0138483365831767 0.9999999999999928 0.0273337835348416 2 P50570 1 +Dynamin GTPase effector [IPR003130] 0.7895314787701322 2.4611735345235535 0.0138483365831767 0.9999999999999928 0.0273337835348416 2 P50570 1 +GTPase effector domain [IPR020850] 0.7895314787701322 2.4611735345235535 0.0138483365831767 0.9999999999999928 0.0273337835348416 2 P50570 1 +CTP synthase, N-terminal [IPR017456] 0.7818448023426086 2.4239795568488174 0.0153514696385212 0.9999999999999998 0.0295026186057178 2 P17812 1 +CTP synthase GATase domain [IPR033828] 0.7818448023426086 2.4239795568488174 0.0153514696385212 0.9999999999999998 0.0295026186057178 2 P17812 1 +Damage-control phosphatase ARMT1-like, metal-binding domain [IPR002791] 0.7730600292825749 2.38128552211654 0.0172523340036638 1.0 0.0325134785299073 2 Q9H993 1 +Glycosyltransferase 2-like [IPR001173] 0.7591508052708605 2.3132802006733013 0.0207072385466622 1.0 0.03739474246439 2 Q86SF2 1 +N-acetylgalactosaminyltransferase [IPR045885] 0.7591508052708605 2.3132802006733013 0.0207072385466622 1.0 0.03739474246439 2 Q86SF2 1 +Reticulon [IPR003388] 0.8502153546504938 2.2919132311106103 0.0219106506151001 1.0 0.0392041143189722 3 Q9NQC3 1 +Zinc finger, B-box, chordata [IPR020457] 0.7445095168374901 2.2411597604306324 0.0250157283402874 1.0 0.0435258760615284 2 P14373 1 +Tim44-like domain [IPR007379] 0.741215226939977 2.224857343123779 0.0260908164184465 1.0 0.0450940461414306 2 O43615 1 +Peptidase M28 [IPR007484] 0.833419639130099 2.2180494362369982 0.0265514618683675 1.0 0.0457547331827588 3 Q7Z2K6 1 +Rhodanese-like domain [IPR001763] 0.7320644216691127 2.1794286514299968 0.0292998396175208 1.0 0.0495044323494291 2 Q99956 1 +Potassium channel tetramerisation-type BTB domain [IPR003131] 0.7280380673499343 2.1593731870225787 0.030821226347653 1.0 0.0515526959324999 2 Q9NXV2 1 +GRAM domain [IPR004182] 0.7218155197657405 2.128298588683109 0.0333123350539374 1.0 0.0547776777119324 2 Q66K14 1 +p21 activated kinase binding domain [IPR033923] 0.7119326500732116 2.0787473694786316 0.0376405766140859 1.0 0.0604891578760431 2 Q13153 1 +CRIB domain [IPR000095] 0.7119326500732116 2.0787473694786316 0.0376405766140859 1.0 0.0604891578760431 2 Q13153 1 +Peptidase M41 [IPR000642] 0.7112005856515367 2.07506734646775 0.0379802935448947 1.0 0.0608675260311113 2 Q96TA2 1 +Dynamin, GTPase domain [IPR001401] 0.7898205785426584 2.0236588312045947 0.0430052672692338 1.0 0.0667224578562531 3 P50570,O60313 2 +FAD dependent oxidoreductase [IPR006076] 0.7885929451742528 2.018131060514351 0.0435776135910166 1.0 0.067520721788337 3 P43304 1 +Aminopeptidase N-like , N-terminal domain [IPR045357] 0.8708154093864938 1.982702643867416 0.0474006541036418 1.0 0.0718549458624527 5 P09960,P55786 2 +Peptidase M1, membrane alanine aminopeptidase [IPR014782] 0.8708154093864938 1.982702643867416 0.0474006541036418 1.0 0.0718549458624527 5 P09960,P55786 2 +Guanylate kinase/L-type calcium channel beta subunit [IPR008145] 0.8696789574575212 1.978061186580195 0.0479218045014471 1.0 0.072331876865468 5 O14936,Q9NZW5,Q14168 3 +Guanylate kinase-like domain [IPR008144] 0.8696789574575212 1.978061186580195 0.0479218045014471 1.0 0.072331876865468 5 O14936,Q9NZW5,Q14168 3 +Major facilitator superfamily domain [IPR020846] 0.7781032588795312 1.9707803550152336 0.0487490046800247 1.0 0.073201881625632 3 P11166,Q7L0J3 2 +Peptidase S9A, N-terminal domain [IPR023302] 0.6855783308931214 1.9454534854335976 0.0517204228234053 1.0 0.0761938090174458 2 P48147 1 +PABP, RNA recognition motif 2 [IPR045305] 0.6844802342606151 1.939863974417845 0.0523962232972206 1.0 0.0769950795462618 2 Q13310 1 +Cation-transporting P-type ATPase, N-terminal [IPR004014] 0.7701146404107877 1.9345797575686705 0.0530418860253278 1.0 0.0776506607330035 3 P16615 1 +Cation-transporting P-type ATPase, C-terminal [IPR006068] 0.7701146404107877 1.9345797575686705 0.0530418860253278 1.0 0.0776506607330035 3 P16615 1 +Intermediate filament head, DNA-binding domain [IPR006821] 0.8549450549450553 1.924988876688652 0.0542307498373388 1.0 0.079192495853775 4 Q16352,P07197,P08670 3 +Peptidyl-prolyl cis-trans isomerase, PpiC-type [IPR000297] 0.6800878477306036 1.9174782118489369 0.0551772063980271 1.0 0.0802233978452013 2 Q13526 1 +Fibronectin type II domain [IPR000562] 0.7617041721048783 1.8963395176793665 0.0579151639631954 1.0 0.0836313592171065 3 Q9UBG0 1 +Intermediate filament, rod domain [IPR039008] 0.7558698621372664 1.8674818765152923 0.0618343253969935 1.0 0.0883617807845654 8 Q16352,P07196,P48681,P07197,P08670 5 +Class II aldolase/adducin N-terminal [IPR001303] 0.6676427525622284 1.8538154971582328 0.0637655605886826 1.0 0.0901832731523767 2 P35611 1 +EB1, C-terminal [IPR004953] 0.6647144948755506 1.8387863963260735 0.0659466099110703 1.0 0.0925949092858384 2 Q15691 1 +Glycogen synthase kinase 3, catalytic domain [IPR039192] 0.6625183016105468 1.8275024378965607 0.0676242599907277 1.0 0.0942139899035496 2 P49840 1 +Cytochrome b5-like heme/steroid binding domain [IPR001199] 0.7889503612266272 1.8035009633005143 0.0713095742925618 1.0 0.0979408517096915 6 Q8WUJ1,O15173,O43169 3 +PI31 proteasome regulator, N-terminal [IPR021625] 0.6537335285505144 1.7822646814247387 0.074706079346221 1.0 0.1021303836495469 2 Q9Y3I1 1 +Alcohol dehydrogenase, N-terminal [IPR013154] 0.7823246626505828 1.7745113592799493 0.0759786048406478 1.0 0.1036273611582434 6 Q8N4Q0,Q8WWV3 2 +NOPS [IPR012975] 0.7341633101428051 1.7702362656647384 0.0766877903147174 1.0 0.1042293308410157 3 P23246,Q15233 2 +P-type ATPase, haloacid dehalogenase domain [IPR044492] 0.8122437610377673 1.7486779738223428 0.0803466994978006 1.0 0.1080457885770217 4 Q9HD20 1 +Polyketide synthase, enoylreductase domain [IPR020843] 0.7520115784342254 1.741142833689182 0.0816585447763209 1.0 0.1095190706793276 7 Q8N4Q0,Q8WWV3 2 +26S proteasome regulatory subunit Rpn7, N-terminal [IPR045135] 0.6456808199121546 1.7406578022660903 0.0817435791343914 1.0 0.1095701821347899 2 Q15008 1 +Prolyl 4-hydroxylase alpha subunit, Fe(2+) 2OG dioxygenase domain [IPR044862] 0.7240327415225716 1.7235288263198851 0.0847929369106046 1.0 0.1126600716818723 3 Q32P28 1 +IMP dehydrogenase/GMP reductase [IPR001093] 0.637628111273795 1.6989239879322937 0.0893335065886797 1.0 0.1179161887419826 2 P20839 1 +Peptidase M3A/M3B catalytic domain [IPR001567] 0.715488831929696 1.6840112267177387 0.0921794990835893 1.0 0.1213298367306545 3 Q9BYT8,Q99797 2 +BAT2, N-terminal [IPR009738] 0.6317715959004424 1.668496072164386 0.0952172910064252 1.0 0.1249760396290067 2 P48634 1 +Heterogeneous nuclear ribonucleoprotein U, SPRY domain [IPR035778] 0.7105180448333246 1.6609696001861962 0.0967195523324346 1.0 0.1262345894849891 3 Q1KMD3 1 +MoaB/Mog domain [IPR001453] 0.62188872620791 1.6170122244966658 0.1058756421838118 1.0 0.1359096341391977 2 Q8NFF5 1 +K Homology domain, type 1 [IPR004088] 0.490149451212525 1.5670880049453924 0.117094122550603 1.0 0.1466030971344011 21 Q96AE4,O75525,O00425,Q9Y6M1,Q07666,Q06787,Q96I24,Q9NQT5,Q15637,P61978,Q92945,Q8TCS8 12 +Ubiquitin-like domain, USP-type [IPR028135] 0.6105417276720395 1.5577062015197516 0.1193029097485711 1.0 0.1488895212522253 2 P51784 1 +K Homology domain [IPR004087] 0.4877496611648977 1.5493149595777054 0.121306025347883 1.0 0.1506646644613334 21 O75525,Q07666,Q96I24,P61978,Q92945 5 +Fragile X-related 1 protein, C-terminal region 1 [IPR032172] 0.6083455344070324 1.54620552432128 0.1220549397734407 1.0 0.1514337323969097 2 P51116 1 +Polyadenylate-binding protein/Hyperplastic disc protein [IPR002004] 0.6847308678139876 1.5408908492290738 0.1233433533186274 1.0 0.1527077041352041 3 Q13310,O95071 2 +Peptidase M16, N-terminal [IPR011765] 0.6843371833612972 1.4296314884009764 0.1528228131266391 1.0 0.1847004496121648 7 P22695,O43847,Q5JRX3,Q10713 4 +Peptidase M16, C-terminal [IPR007863] 0.6843371833612972 1.4296314884009764 0.1528228131266391 1.0 0.1847004496121648 7 P22695,O43847,Q5JRX3,Q10713 4 +ABC transporter type 1, transmembrane domain [IPR011527] 0.7313018160454245 1.4082237613508757 0.1590648223953581 1.0 0.1921450389514543 4 P08183,O75027 2 +Target SNARE coiled-coil homology domain [IPR000727] 0.6935027968833021 1.3799224608348868 0.1676105201506121 1.0 0.2018742233627856 6 O15400,Q13190,Q9UEU0 3 +Heat shock protein DnaJ, cysteine-rich domain [IPR001305] 0.6481142438667156 1.369140279736282 0.1709554294721667 1.0 0.2055514561367195 3 O60884,Q96EY1 2 +Major sperm protein (MSP) domain [IPR000535] 0.6430499427580569 1.3453081220774858 0.1785257517466276 1.0 0.2141566160549677 3 Q9P0L0 1 +Mad3/Bub1 homology region 1 [IPR013212] 0.5647877013177229 1.3170303465264306 0.1878284526913822 1.0 0.2244521172130898 2 O43683 1 +Agenet-like domain [IPR008395] 0.6314808547114661 1.2908267567078424 0.1967637575070089 1.0 0.2342903486888657 3 Q06787 1 +Fxr1, tudor domain [IPR041560] 0.6314808547114661 1.2908267567078424 0.1967637575070089 1.0 0.2342903486888657 3 Q06787 1 +Fragile X-related 1 protein, C-terminal core [IPR022034] 0.6314808547114661 1.2908267567078424 0.1967637575070089 1.0 0.2342903486888657 3 Q06787 1 +Synaptic functional regulator FMRP, KH0 domain [IPR040472] 0.6314808547114661 1.2908267567078424 0.1967637575070089 1.0 0.2342903486888657 3 Q06787 1 +Zinc finger, RanBP2-type [IPR001876] 0.6347305737672788 1.2891908944465629 0.1973317298113781 1.0 0.2348468853769459 8 P35637,Q01844,Q92804 3 +FKBP-type peptidyl-prolyl cis-trans isomerase domain [IPR001179] 0.6039178729081947 1.2336599150264895 0.2173296566936373 1.0 0.2568141439168235 9 P62942,Q9NWM8 2 +Lamin tail domain [IPR001322] 0.6162577810325889 1.219106792768636 0.2228036620463851 1.0 0.2628835527429556 3 Q03252,P02545 2 +Ubiquitin carboxyl-terminal hydrolase, C-terminal [IPR029346] 0.6107652874404981 1.193237037391667 0.2327765531870573 1.0 0.2738202779303672 3 Q93009,P51784 2 +ZU5 domain [IPR000906] 0.5406295754026438 1.1895603014877565 0.2342192568036383 1.0 0.2753786327474801 2 Q12955 1 +Ribosomal protein S10 domain [IPR027486] 0.5344070278184542 1.1567646171905832 0.2473685415062263 1.0 0.2901082593757099 2 P60866 1 +TRASH domain [IPR011017] 0.5333089311859533 1.1509805115284966 0.2497402531680448 1.0 0.292449092852249 2 Q9UBW7 1 +R3H domain [IPR001374] 0.5983592706251406 1.1348527075017107 0.2564370378898064 1.0 0.2992406214256362 3 Q9H6S0 1 +NUC153 [IPR012580] 0.5285505124451022 1.125930334674054 0.2601950081851409 1.0 0.3033226880241159 2 Q9H501 1 +CBS domain [IPR000644] 0.6367680453407416 1.1244036619990414 0.2608418192341588 1.0 0.3039249740078646 6 P51790 1 +GTP binding protein, second domain [IPR031662] 0.5223279648609146 1.0932141441783785 0.274299788293709 1.0 0.3183349928756514 2 Q9Y295 1 +Peptidase S9, prolyl oligopeptidase, catalytic domain [IPR001375] 0.6557703602383066 1.0869932447123205 0.2770397951527354 1.0 0.3213551523505402 4 P48147,Q86TI2 2 +SKP1 component, POZ domain [IPR016073] 0.5208638360175764 1.0855242733993336 0.2776895188981192 1.0 0.3219488712150488 2 P63208 1 +PDZ domain [IPR001478] 0.4481263212649886 1.0528455288747545 0.2924117944619344 1.0 0.3361799803390531 16 O14936,Q14168,Q00013,Q9NZW5 4 +Legume-like lectin [IPR005052] 0.5091508052708726 1.0241427848143472 0.3057678384199724 1.0 0.3498127891771855 2 Q12907 1 +SPRY domain [IPR003877] 0.5254118557792 1.020683272608775 0.3074045221314063 1.0 0.3513409491810249 11 P14373,Q9BUJ2,Q1KMD3,Q12899 4 +B30.2/SPRY domain [IPR001870] 0.5254118557792 1.020683272608775 0.3074045221314063 1.0 0.3513409491810249 11 P14373,Q9BUJ2,Q1KMD3,Q12899 4 +Dynamin-type guanine nucleotide-binding (G) domain [IPR030381] 0.5821132812862996 0.9526255566539052 0.3407798236718333 1.0 0.3865227996911349 7 P50570,O60313,Q8IWA4 3 +Dynamin, N-terminal [IPR045063] 0.5821132812862996 0.9526255566539052 0.3407798236718333 1.0 0.3865227996911349 7 P50570,O60313,Q8IWA4 3 +RAD23A/RAD23B, UBA1 domain [IPR041811] 0.4952415812591604 0.9516647932093932 0.3412670099979817 1.0 0.3865227996911349 2 P54725 1 +XPC-binding domain [IPR015360] 0.4952415812591604 0.9516647932093932 0.3412670099979817 1.0 0.3865227996911349 2 P54725 1 +TRIAD supradomain [IPR044066] 0.4901171303074783 0.9251073922742814 0.3549100482194598 1.0 0.3997660215110654 2 Q9Y4X5 1 +IBR domain [IPR002867] 0.4901171303074783 0.9251073922742814 0.3549100482194598 1.0 0.3997660215110654 2 Q9Y4X5 1 +Sec63 domain [IPR004179] 0.5521786891248629 0.919115024392776 0.3580354114895678 1.0 0.403091941093607 3 O75643,Q9UGP8 2 +Sec23, C-terminal [IPR037550] 0.4886530014641365 0.917536201597041 0.3588617317704949 1.0 0.4038275391248702 2 Q15436 1 +CTLH, C-terminal LisH motif [IPR006595] 0.4879209370424667 0.913753523260608 0.360846372901372 1.0 0.4058044997183341 2 Q96S59 1 +ELM2 domain [IPR000949] 0.4853587115666288 0.9005299666468155 0.3678382853412578 1.0 0.4129338443614601 2 Q13330 1 +Metastasis-associated protein MTA1, R1 domain [IPR035170] 0.4853587115666288 0.9005299666468155 0.3678382853412578 1.0 0.4129338443614601 2 Q13330 1 +Zinc finger, CCHC-type [IPR001878] 0.5701939903063045 0.8974404154684252 0.3694839547137827 1.0 0.4145819482252199 7 Q9BWF3,Q15637,Q9BQ04,Q9NUD5 4 +JAB1/MPN/MOV34 metalloenzyme domain [IPR000555] 0.5419303290866514 0.8400508630739906 0.4008798688341377 1.0 0.4457402351084341 8 Q7L5N1 1 +GINS subunit, domain A [IPR021151] 0.5291102160380812 0.8132239850028622 0.4160896502312301 1.0 0.4600233585653042 3 Q9BRT9,Q9Y248 2 +ENTH domain [IPR013809] 0.4677891654465714 0.810614592868915 0.4175870339236196 1.0 0.4614603522061769 2 Q14677 1 +Chromo shadow domain [IPR008251] 0.5228853899670451 0.7849843875127468 0.4324627224339687 1.0 0.4767707539581289 3 Q13185,P45973 2 +Chromo domain subgroup [IPR017984] 0.5228853899670451 0.7849843875127468 0.4324627224339687 1.0 0.4767707539581289 3 Q13185,P45973 2 +ABC transporter-like, ATP-binding domain [IPR003439] 0.5449778691646638 0.7818028871852637 0.4343304240181598 1.0 0.4786038414735267 7 P08183,O75027 2 +Lens epithelium-derived growth factor, integrase-binding domain [IPR021567] 0.4608345534407156 0.7754550097134539 0.4380708405120046 1.0 0.4820430785087327 2 Q7Z4V5 1 +LEM domain [IPR003887] 0.5570047894396545 0.7691659804296207 0.4417947831793176 1.0 0.4859118317115905 6 P42167,Q86XL3 2 +Class I myosin, motor domain [IPR036072] 0.4593704245973684 0.7680890323350154 0.4424342923666633 1.0 0.4861572106711336 2 O94832 1 +Class I myosin tail homology domain [IPR010926] 0.4593704245973684 0.7680890323350154 0.4424342923666633 1.0 0.4861572106711336 2 O94832 1 +EF-hand domain [IPR002048] 0.3316543996655238 0.7561121744982016 0.4495819432231089 1.0 0.4932924681517656 42 O95202,O43852,P80303,Q14257,Q9NWM8,Q9BRK5,Q02818,Q9Y680 8 +AMP-binding enzyme, C-terminal domain [IPR025110] 0.4542459736456934 0.7424141992277671 0.4578364191360493 1.0 0.5011945797855955 2 Q6P1M0 1 +PTB/PI domain [IPR006020] 0.5111680703039179 0.7323028989223413 0.4639837103336839 1.0 0.5073922097903053 3 Q9UKG1,Q9Y3P9 2 +Nucleotidyl transferase domain [IPR005835] 0.5090736424680631 0.7229582835139601 0.4697055139996686 1.0 0.5120272526560347 3 Q9Y5P6 1 +Pleckstrin homology domain [IPR001849] 0.3827253364824613 0.7108016404250032 0.4772071639591271 1.0 0.5197195558976501 19 P31751,Q9BZF3 2 +HECT domain [IPR000569] 0.5377109093742541 0.6857577909684003 0.4928658572188544 1.0 0.535275244933035 6 Q05086,Q96J02 2 +Ribosomal protein L18e/L15P [IPR021131] 0.5005492493592092 0.6851749675230532 0.4932335180518168 1.0 0.535425506578797 3 P46776,Q9P015 2 +Arginyl-tRNA synthetase, catalytic core domain [IPR035684] 0.4418008784773016 0.6808188891854224 0.4959860962861477 1.0 0.5379133928602671 2 Q5T160 1 +DALR anticodon binding [IPR008909] 0.4418008784773016 0.6808188891854224 0.4959860962861477 1.0 0.5379133928602671 2 Q5T160 1 +SCP2 sterol-binding domain [IPR003033] 0.4965214207250094 0.6674708426136371 0.5044714280443552 1.0 0.5458483709377059 3 Q6YN16,P51659 2 +Exonuclease, RNase T/DNA polymerase III [IPR013520] 0.434114202049775 0.6433812090951598 0.5199767733162952 1.0 0.5616392370313575 2 Q9GZR2 1 +RNA recognition motif domain, eukaryote [IPR003954] 0.4059956958481317 0.5923904648431271 0.5535891499184287 1.0 0.5937669568486591 13 P31483,Q01085,P38159 3 +CAP Gly-rich domain [IPR000938] 0.4209370424597333 0.5804562844883172 0.5616069585635644 1.0 0.6020901047961078 2 Q15813 1 +Glutamine amidotransferase [IPR017926] 0.5258376129202335 0.5550281515038261 0.5788754050915914 1.0 0.6186151354182453 4 P17812 1 +Peptidase C19, ubiquitin-specific peptidase, DUSP domain [IPR006615] 0.466495789088246 0.53909331570259 0.5898224675774597 1.0 0.6300253713601869 3 Q9Y4E8,P51784 2 +Immunoglobulin I-set [IPR013098] 0.4110541727672014 0.5344471603567538 0.5930321979358091 1.0 0.6328748547441108 2 Q13308 1 +SPRY-associated [IPR006574] 0.4974170848374865 0.5177888809710584 0.6046055770036789 1.0 0.6431681195004967 6 P14373,P19474,Q12899 3 +Butyrophylin-like, SPRY domain [IPR003879] 0.4974170848374865 0.5177888809710584 0.6046055770036789 1.0 0.6431681195004967 6 P14373,P19474,Q12899 3 +Exportin-2, central domain [IPR013713] 0.4452581471988284 0.4530188307831777 0.6505351819465641 1.0 0.6876413082142269 3 P55060,O95373 2 +Helicase/UvrB, N-terminal [IPR006935] 0.4379348224093739 0.4244433792899105 0.6712424901647511 1.0 0.707288454212407 3 P19447,Q9UPY3 2 +Myosin tail [IPR002928] 0.4335408275357013 0.407599043252338 0.6835680668327782 1.0 0.7183309793224739 3 P35580,P35579 2 +Glutamine amidotransferase type 2 domain [IPR017932] 0.4298791651409741 0.3937423747991112 0.6937712527506161 1.0 0.7276380139489068 3 Q06203,Q06210 2 +MPN domain [IPR037518] 0.4313934007445313 0.3934558748210363 0.6939828081645463 1.0 0.7276380139489068 9 Q7L5N1 1 +YTH domain [IPR007275] 0.474443907303716 0.3693334685735206 0.7118791819312646 1.0 0.744730237369849 4 Q96MU7,Q9H6S0 2 +Transcription factor CBF/NF-Y/archaeal histone domain [IPR003958] 0.4082753570120835 0.3156065777236735 0.7523011443938066 1.0 0.7835072132736567 3 Q9NR33,Q9NRF9 2 +Adenylate kinase, active site lid domain [IPR007862] 0.356881405563685 0.3064277704415185 0.7592789668962632 1.0 0.7900696914896499 2 P27144 1 +TGS [IPR004095] 0.4408580573622445 0.3042468703918723 0.7609398188343564 1.0 0.7913871775697472 6 Q9NYK5,Q9BW92,Q9Y295 3 +Coatomer, gamma subunit, appendage, Ig-like subdomain [IPR013040] 0.3495607613469923 0.2795229572535964 0.7798435225171203 1.0 0.8093042778122116 2 Q9Y678 1 +Coatomer subunit gamma, C-terminal [IPR032154] 0.3495607613469923 0.2795229572535964 0.7798435225171203 1.0 0.8093042778122116 2 Q9Y678 1 +JmjC domain [IPR003347] 0.4457792314972886 0.2771471210667517 0.7816671409687772 1.0 0.8108364167756974 4 Q8IUF8 1 +Acyl-CoA oxidase/dehydrogenase, central domain [IPR006091] 0.4225528507445468 0.2733517312360619 0.7845828531240162 1.0 0.8131384651773538 7 O15254,Q15067 2 +Zinc finger, GATA-type [IPR000679] 0.4384615384615401 0.2552127356798112 0.7985587950503472 1.0 0.8261563076838994 4 Q86YP4,Q13330,O94776 3 +Ricin B, lectin domain [IPR000772] 0.436633815786797 0.2498435858551528 0.802708311724345 1.0 0.8300814472437315 4 Q86SF2,Q9UBG0 2 +B-box-type zinc finger [IPR000315] 0.4001184554926129 0.2271572801053306 0.8203014449110004 1.0 0.846546820017155 8 P14373,O15164,Q12899 3 +ATP-dependent RNA helicase eIF4A, DEAD-box helicase domain [IPR044728] 0.3169838945827155 0.1738389309475965 0.8619920477124603 1.0 0.8847259039158658 2 Q14240 1 +MCM N-terminal domain [IPR027925] 0.3907624633431089 0.1482615861781141 0.8821363300490748 1.0 0.9018337699932528 6 P49736,Q14566,P25205,P33993,P33992 5 +MCM domain [IPR001208] 0.3907624633431089 0.1482615861781141 0.8821363300490748 1.0 0.9018337699932528 6 P49736,Q14566,P25205,P33993,P33992 5 +MCM, AAA-lid domain [IPR041562] 0.3907624633431089 0.1482615861781141 0.8821363300490748 1.0 0.9018337699932528 6 P49736,Q14566,P25205,P33993,P33992 5 +MCM OB domain [IPR033762] 0.3907624633431089 0.1482615861781141 0.8821363300490748 1.0 0.9018337699932528 6 P49736,Q14566,P25205,P33993,P33992 5 +Circularly permuted (CP)-type guanine nucleotide-binding (G) domain [IPR030378] 0.3933824930032514 0.1366494015573671 0.8913079259327101 1.0 0.909219749695447 4 Q13823 1 +Chaperone DnaJ, C-terminal [IPR002939] 0.3808312102713607 0.1091366841564664 0.913094078905206 1.0 0.9286039521967144 4 O60884,Q96EY1 2 +Protein kinase domain [IPR000719] 0.2613158749128542 0.0975671067633197 0.9222760448503317 1.0 0.9367179489889188 46 Q99640,P48729,P11802,P31751,P36507,O14936,Q13153,Q13555,Q13546 9 +DnaJ domain [IPR001623] 0.3035648658581481 0.0715641322660529 0.9429487851619917 1.0 0.9552214374634492 13 Q9NVH1,P31689,Q99543,Q13217,P25685,Q96EY1,Q9UGP8,Q96KC8,O75937,Q99615,O60884,Q8IXB1 12 +Importin-beta, N-terminal domain [IPR001494] 0.3009450749496483 0.0612762660875588 0.9511391921937556 1.0 0.9626831442446552 13 Q8TEX9 1 +Aminotransferase, class I/classII [IPR004839] 0.3372552454869781 0.0317834065121777 0.9746447796363156 1.0 0.9843406403333896 7 Q6YP21 1 +Zinc finger, RING-type [IPR001841] 0.2710520145081824 0.0050218846867569 0.9959931325840604 1.0 1.0 20 P14373,O15164,Q12899,P19474,Q14527 5 diff --git a/interpro_domain/selections.json b/interpro_domain/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..aea5ee2d01819005db5d41b7844f483e1211aa9f --- /dev/null +++ b/interpro_domain/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["1-acyl-sn-glycerol-3-phosphate acyltransferase [IPR004552]", "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, SH3 domain [IPR035724]", "116kDa U5 small nuclear ribonucleoprotein component, C-terminal [IPR035655]", "116kDa U5 small nuclear ribonucleoprotein component, N-terminal [IPR031950]", "14-3-3 domain [IPR023410]", "2-oxoacid dehydrogenase acyltransferase, catalytic domain [IPR001078]", "2-oxoglutarate dehydrogenase E1 component, N-terminal domain [IPR032106]", "26S proteasome non-ATPase regulatory subunit RPN1, C-terminal [IPR041433]", "26S proteasome regulatory subunit RPN2, C-terminal [IPR040623]", "26S proteasome regulatory subunit RPN5, C-terminal domain [IPR040896]", "26S proteasome regulatory subunit Rpn6, N-terminal [IPR040773]", "26S proteasome regulatory subunit Rpn7, N-terminal [IPR045135]", "26S proteasome regulatory subunit, C-terminal [IPR013586]", "2Fe-2S ferredoxin-type iron-sulfur binding domain [IPR001041]", "3'-5' exonuclease domain [IPR002562]", "3-beta hydroxysteroid dehydrogenase/isomerase [IPR002225]", "3-hydroxyacyl-CoA dehydrogenase, C-terminal [IPR006108]", "3-hydroxyacyl-CoA dehydrogenase, NAD binding [IPR006176]", "3-hydroxyisobutyrate dehydrogenase, NAD-binding domain [IPR029154]", "3-oxo-5-alpha-steroid 4-dehydrogenase, C-terminal [IPR001104]", "4'-phosphopantetheinyl transferase domain [IPR008278]", "40S ribosomal protein S11, N-terminal [IPR032440]", "40S ribosomal protein S4, C-terminal domain [IPR032277]", "40S ribosomal protein SA, C-terminal domain [IPR032281]", "4Fe-4S ferredoxin-type, iron-sulphur binding domain [IPR017896]", "6-phosphogluconate dehydrogenase, C-terminal [IPR006114]", "6-phosphogluconate dehydrogenase, NADP-binding [IPR006115]", "6-phosphogluconolactonase, DevB-type [IPR005900]", "60S ribosomal protein L10P, insertion domain [IPR040637]", "60S ribosomal protein L4, C-terminal domain [IPR025755]", "6S proteasome subunit Rpn6, C-terminal helix domain [IPR040780]", "A kinase-anchoring protein AKAP5 and AKAP12, calmodulin (CaM)-binding motif [IPR001573]", "AAA ATPase, AAA+ lid domain [IPR041569]", "AAA+ ATPase domain [IPR003593]", "AAR2, C-terminal [IPR033648]", "AAR2, N-terminal [IPR033647]", "AARP2CN [IPR012948]", "AATF leucine zipper-containing domain [IPR025160]", "ABC transporter type 1, transmembrane domain [IPR011527]", "ABC transporter-like, ATP-binding domain [IPR003439]", "ABC-transporter extension domain [IPR032781]", "ABC1 atypical kinase-like domain [IPR004147]", "ADAR1, first double-stranded RNA binding domain [IPR044456]", "ADAR1, third double-stranded RNA binding domain [IPR044457]", "ADCK3-like domain [IPR034646]", "ADNP, zinc finger domain [IPR045762]", "AGC-kinase, C-terminal [IPR000961]", "AIMP2, lysyl-tRNA synthetase binding domain [IPR031889]", "AIMP2, thioredoxin-like domain [IPR041503]", "ALIX V-shaped domain [IPR025304]", "AMP-binding enzyme, C-terminal domain [IPR025110]", "AMP-dependent synthetase/ligase [IPR000873]", "AP complex, mu/sigma subunit [IPR022775]", "AP-2 complex subunit mu, N-terminal [IPR043532]", "AP-3 complex subunit beta 1, serine-rich domain [IPR029394]", "AP-3 complex subunit beta, C-terminal domain [IPR029390]", "AP-3 complex subunit delta domain, metazoa [IPR010474]", "AP180 N-terminal homology (ANTH) domain [IPR011417]", "APPL1, BAR domain [IPR037929]", "ARHGEF1-like, PH domain [IPR041020]", "ARHGEF2, PH domain [IPR037806]", "ARID DNA-binding domain [IPR001606]", "ATP synthase, F1 complex, alpha subunit nucleotide-binding domain [IPR033732]", "ATP synthase, alpha subunit, C-terminal [IPR000793]", "ATP-citrate lyase/succinyl-CoA ligase [IPR005811]", "ATP-citrate synthase, citrate-binding domain [IPR032263]", "ATP-cone domain [IPR005144]", "ATP-dependent DNA helicase RecQ, zinc-binding domain [IPR032284]", "ATP-dependent RNA helicase Ski2, C-terminal [IPR012961]", "ATP-dependent RNA helicase eIF4A, DEAD-box helicase domain [IPR044728]", "ATP-dependent helicase, C-terminal [IPR006555]", "ATP-grasp fold [IPR011761]", "ATP-grasp fold, succinyl-CoA synthetase-type [IPR013650]", "ATP-sulfurylase PUA-like domain [IPR025980]", "ATP:guanido phosphotransferase, N-terminal [IPR022413]", "ATP:guanido phosphotransferase, catalytic domain [IPR022414]", "ATPase family AAA domain-containing protein 3, N-terminal [IPR021911]", "ATPase, AAA-type, core [IPR003959]", "ATPase, BadF/BadG/BcrA/BcrD type [IPR002731]", "ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain [IPR004100]", "ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domain [IPR000194]", "ATPase, V1 complex, subunit H, C-terminal [IPR011987]", "ATPase, dynein-related, AAA domain [IPR011704]", "ATPsynthase alpha/beta subunit, N-terminal extension [IPR031686]", "AWS domain [IPR006560]", "Abscisic acid G-protein coupled receptor-like domain [IPR025969]", "Acetyl-CoA carboxylase [IPR034733]", "Acetyl-CoA carboxylase, central domain [IPR013537]", "Acetyl-coA carboxylase zinc finger domain [IPR041010]", "Acetyl-coenzyme A carboxyltransferase, C-terminal [IPR011763]", "Acetyl-coenzyme A carboxyltransferase, N-terminal [IPR011762]", "Acid ceramidase, N-terminal [IPR029130]", "Acinus, RNA recognition motif [IPR034257]", "Aconitase A, swivel domain [IPR044137]", "Aconitase A/isopropylmalate dehydratase small subunit, swivel domain [IPR000573]", "Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain [IPR001030]", "Actin-depolymerising factor homology domain [IPR002108]", "Activator of Hsp90 ATPase, N-terminal [IPR015310]", "Acyl transferase [IPR014043]", "Acyl-CoA dehydrogenase/oxidase C-terminal [IPR009075]", "Acyl-CoA dehydrogenase/oxidase, N-terminal [IPR013786]", "Acyl-CoA oxidase, C-terminal [IPR002655]", "Acyl-CoA oxidase/dehydrogenase, central domain [IPR006091]", "Acyl-CoA-binding protein, ACBP [IPR000582]", "Acyl-coenzyme A oxidase, N-terminal [IPR029320]", "Acylamino-acid-releasing enzyme, N-terminal domain [IPR045550]", "Acylglycerol kinase, C-terminal [IPR045579]", "Adenomatous polyposis coli protein basic domain [IPR009234]", "Adenomatous polyposis coli, N-terminal dimerisation domain [IPR032038]", "Adenosine deaminase domain [IPR001365]", "Adenosine deaminase/editase [IPR002466]", "Adenylate cyclase-associated CAP, C-terminal [IPR013912]", "Adenylate cyclase-associated CAP, N-terminal [IPR013992]", "Adenylate kinase, active site lid domain [IPR007862]", "Adenylosuccinate lyase C-terminal [IPR019468]", "Afadin, cargo binding domain [IPR037977]", "Agenet-like domain [IPR008395]", "Alanine dehydrogenase/pyridine nucleotide transhydrogenase, N-terminal [IPR007886]", "Alanine dehydrogenase/pyridine nucleotide transhydrogenase, NAD(H)-binding domain [IPR007698]", "Alanyl-tRNA synthetase, class IIc, N-terminal [IPR018164]", "Alanyl-tRNA synthetase, class IIc, core domain [IPR018165]", "Alcohol dehydrogenase, N-terminal [IPR013154]", "Alcohol dehydrogenase-like, C-terminal [IPR013149]", "Aldehyde dehydrogenase domain [IPR015590]", "Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant [IPR000866]", "Alpha Spectrin, SH3 domain [IPR035825]", "Alpha crystallin/Hsp20 domain [IPR002068]", "Alpha galactosidase A, C-terminal beta-sandwich domain [IPR035373]", "Alpha-2-macroglobulin RAP, C-terminal [IPR010483]", "Alpha-2-macroglobulin RAP, domain 2 [IPR038001]", "Alpha-2-macroglobulin RAP, domain 3 [IPR037999]", "Alpha-2-macroglobulin receptor-associated protein, domain 1 [IPR009066]", "Alpha-D-phosphohexomutase, C-terminal [IPR005843]", "Alpha-D-phosphohexomutase, alpha/beta/alpha domain I [IPR005844]", "Alpha-D-phosphohexomutase, alpha/beta/alpha domain II [IPR005845]", "Alpha-D-phosphohexomutase, alpha/beta/alpha domain III [IPR005846]", "Alpha-L-fucosidase, C-terminal [IPR031919]", "Alpha-N-acetylglucosaminidase, C-terminal [IPR024732]", "Alpha-N-acetylglucosaminidase, N-terminal [IPR024240]", "Alpha-N-acetylglucosaminidase, tim-barrel domain [IPR024733]", "Alpha-amylase/branching enzyme, C-terminal all beta [IPR006048]", "Alpha-glycerophosphate oxidase, C-terminal [IPR031656]", "Alpha-ketoglutarate-dependent dioxygenase AlkB-like [IPR027450]", "Alpha-ketoglutarate-dependent dioxygenase FTO, C-terminal [IPR024366]", "Alpha-ketoglutarate-dependent dioxygenase FTO, catalytic domain [IPR024367]", "Alpha/beta hydrolase fold-1 [IPR000073]", "Amidase signature domain [IPR023631]", "Amidohydrolase-related [IPR006680]", "Amidophosphoribosyltransferase, N-terminal [IPR035584]", "Amine oxidase [IPR002937]", "Amino acid transporter, transmembrane domain [IPR013057]", "Aminoacyl-tRNA synthetase, class I, anticodon-binding [IPR045462]", "Aminoacyl-tRNA synthetase, class II (D/K/N) [IPR004364]", "Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) [IPR002314]", "Aminoacyl-tRNA synthetase, class II [IPR006195]", "Aminoacyl-tRNA synthetase, class Ia [IPR002300]", "Aminopeptidase N-like , N-terminal domain [IPR045357]", "Aminopeptidase P [IPR033740]", "Aminopeptidase P, N-terminal [IPR007865]", "Aminotransferase class V domain [IPR000192]", "Aminotransferase, class I/classII [IPR004839]", "Amyloidogenic glycoprotein, E2 domain [IPR024329]", "Amyloidogenic glycoprotein, amyloid-beta peptide [IPR013803]", "Amyloidogenic glycoprotein, copper-binding [IPR011178]", "Amyloidogenic glycoprotein, extracellular [IPR008154]", "Amyloidogenic glycoprotein, heparin-binding [IPR015849]", "Anaphase-promoting complex subunit 1, C-terminal [IPR041221]", "Anaphase-promoting complex subunit 4 long domain [IPR024790]", "Anaphase-promoting complex subunit 4, WD40 domain [IPR024977]", "Anaphase-promoting complex subunit 5 domain [IPR026000]", "Ancestral coatomer element 1, Sec16/Sec31 [IPR024298]", "Angiomotin, C-terminal [IPR024646]", "Anillin homology domain [IPR012966]", "Anillin, N-terminal domain [IPR031970]", "Anillin, PH domain [IPR037840]", "Anion-transporting ATPase-like domain [IPR025723]", "Ankyrin repeat and LEM domain-containing protein 2, LEM domain [IPR035006]", "Ankyrin, UPA domain [IPR040745]", "Ankyrin-3, death domain [IPR037971]", "Anticodon-binding [IPR004154]", "Anticodon-binding domain [IPR019181]", "Antifreeze-like/N-acetylneuraminic acid synthase C-terminal [IPR006190]", "ApaG domain [IPR007474]", "Apoptosis-antagonizing transcription factor, C-terminal [IPR012617]", "Arf GTPase activating protein [IPR001164]", "Arfaptin homology (AH) domain [IPR010504]", "Arginyl tRNA synthetase N-terminal domain [IPR005148]", "Arginyl-tRNA synthetase, catalytic core domain [IPR035684]", "Ariadne domain [IPR045840]", "Armadillo repeat-containing domain [IPR006911]", "Aromatic amino acid beta-eliminating lyase/threonine aldolase [IPR001597]", "Asn/Gln amidotransferase [IPR018027]", "Asparagine synthase [IPR001962]", "Asparagine synthase, N-terminal domain [IPR033738]", "Aspartate/glutamate/uridylate kinase [IPR001048]", "Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding domain [IPR006131]", "Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding [IPR006132]", "Aspartic peptidase, DDI1-type [IPR019103]", "Aspartyl beta-hydroxylase/Triadin domain [IPR007943]", "Aspartyl/Glutamyl-tRNA(Gln) amidotransferase, subunit B/E, catalytic [IPR006075]", "Aspartyl/asparaginy/proline hydroxylase [IPR007803]", "Ataxin 2, SM domain [IPR025852]", "Ataxin-10 domain [IPR019156]", "Ataxin-2, C-terminal [IPR009818]", "Aurora kinase A [IPR030611]", "Aurora-A binding [IPR015128]", "B-block binding subunit of TFIIIC [IPR007309]", "B-box, C-terminal [IPR003649]", "B-box-type zinc finger [IPR000315]", "B3/B4 tRNA-binding domain [IPR005146]", "B30.2/SPRY domain [IPR001870]", "BAG domain [IPR003103]", "BAP29/BAP31, transmembrane domain [IPR040463]", "BAR domain [IPR004148]", "BAT2, N-terminal [IPR009738]", "BCAS3 domain [IPR022175]", "BCS1, N-terminal [IPR014851]", "BEACH domain [IPR000409]", "BING4, C-terminal domain [IPR012952]", "BOP1, N-terminal domain [IPR012953]", "BP28, C-terminal domain [IPR012954]", "BRCT domain [IPR001357]", "BRK domain [IPR006576]", "BRO1 domain [IPR004328]", "BSD domain [IPR005607]", "BTB/Kelch-associated [IPR011705]", "BTB/POZ domain [IPR000210]", "BURAN domain [IPR045354]", "BZW1/2, W2 domain [IPR043510]", "Bacterial Ig-like, group 2 [IPR003343]", "Bacterial surface antigen (D15) [IPR000184]", "Band 4.1 domain [IPR019749]", "Band 4.1, C-terminal [IPR008379]", "Band 7 domain [IPR001107]", "Band 7, C-terminal extension [IPR032435]", "Bap31/Bap29 cytoplasmic coiled-coil domain [IPR041672]", "Beta-Casp domain [IPR022712]", "Beta-adaptin appendage, C-terminal subdomain [IPR015151]", "Beta-amyloid precursor protein C-terminal [IPR019543]", "Beta-catenin-interacting ICAT domain [IPR009428]", "Beta-catenin-like protein 1, N-terminal [IPR013180]", "Beta-galactosidase jelly roll domain [IPR025300]", "Beta-hexosaminidase, eukaryotic type, N-terminal [IPR029019]", "Beta-ketoacyl synthase, C-terminal [IPR014031]", "Beta-ketoacyl synthase, N-terminal [IPR014030]", "Bifunctional delta 1-pyrroline-5-carboxylate synthetase, glutamate-5-kinase domain [IPR041744]", "Biliverdin reductase, catalytic [IPR015249]", "Biotin carboxylase, C-terminal [IPR005482]", "Biotin carboxylase-like, N-terminal domain [IPR005481]", "Biotin carboxylation domain [IPR011764]", "Biotin protein ligase, C-terminal [IPR003142]", "Biotin-protein ligase, N-terminal [IPR019197]", "Biotin/lipoyl attachment [IPR000089]", "Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL), catalytic domain [IPR004143]", "Bms1/Tsr1-type G domain [IPR030387]", "Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase, N-terminal [IPR018955]", "Brdt, bromodomain, repeat I [IPR043508]", "Brdt, bromodomain, repeat II [IPR043509]", "Brix domain [IPR007109]", "Bromo adjacent homology (BAH) domain [IPR001025]", "Bromodomain [IPR001487]", "Bromodomain adjacent to zinc finger domain protein 1A, bromodomain [IPR037325]", "Bromodomain protein 4, C-terminal [IPR031354]", "Brr2, N-terminal helicase PWI domain [IPR041094]", "Butyrophylin-like, SPRY domain [IPR003879]", "C-CAP/cofactor C-like domain [IPR017901]", "C-terminal associated domain of TOPRIM [IPR031660]", "C-type lectin-like [IPR001304]", "C2 DOCK-type domain [IPR027007]", "C2 domain [IPR000008]", "C2 phosphatidylinositol 3-kinase-type domain [IPR002420]", "C4-type zinc-finger of DNA polymerase delta [IPR025687]", "CAAX prenyl protease 1, N-terminal [IPR032456]", "CAP Gly-rich domain [IPR000938]", "CARG-binding factor, N-terminal [IPR012956]", "CARP motif [IPR006599]", "CASK, SH3 domain [IPR035473]", "CBS domain [IPR000644]", "CCAAT-binding factor [IPR005612]", "CCDC93, coiled-coil domain [IPR019159]", "CCR4-NOT transcription complex subunit 1, CAF1-binding domain [IPR032191]", "CCR4-NOT transcription complex subunit 1, HEAT repeat [IPR032194]", "CCR4-NOT transcription complex subunit 1, TTP binding domain [IPR032193]", "CCR4-NOT transcription complex subunit 1, domain 4 [IPR024557]", "CCR4-Not complex component, Not1, C-terminal [IPR007196]", "CD2-associated protein, first SH3 domain [IPR035775]", "CD2-associated protein, second SH3 domain [IPR035776]", "CD2-associated protein, third SH3 domain [IPR035777]", "CD209-like, C-type lectin-like domain [IPR033989]", "CD47 immunoglobulin-like [IPR013270]", "CD47 transmembrane [IPR013147]", "CDC48, N-terminal subdomain [IPR003338]", "CDC48, domain 2 [IPR004201]", "CDH1/2, SANT-Helical linker 1 [IPR040793]", "CELF1/2, RNA recognition motif 1 [IPR034196]", "CELF1/2, RNA recognition motif 2 [IPR034198]", "CELF1/2, RNA recognition motif 3 [IPR034199]", "CENP-T/Histone H4, histone fold [IPR035425]", "CENP-V/GFA domain [IPR006913]", "CFA20 domain [IPR007714]", "CHCH [IPR010625]", "CHD subfamily II, SANT-like domain [IPR009462]", "CHD, C-terminal 2 [IPR012957]", "CHD, N-terminal [IPR012958]", "CHIP, N-terminal tetratricopeptide repeat domain [IPR041312]", "CHIP/LubX , U box domain [IPR045202]", "CHORD domain [IPR007051]", "CID domain [IPR006569]", "CIDE-N domain [IPR003508]", "CLASP N-terminal domain [IPR024395]", "CLU central domain [IPR033646]", "CLU domain [IPR025697]", "CNNM, transmembrane domain [IPR002550]", "COG complex component, COG2, C-terminal [IPR024603]", "COMM domain [IPR017920]", "COP9 signalosome complex subunit 4, helix turn helix domain [IPR041406]", "COP9 signalosome complex subunit 7, helix I [IPR041481]", "COQ9 [IPR013718]", "COS domain [IPR017903]", "CP2 transcription factor [IPR007604]", "CPL domain [IPR012959]", "CPPED1, metallophosphatase domain [IPR041867]", "CPSF2, metallo-hydrolase domain [IPR035639]", "CPSF7, RNA recognition motif [IPR034773]", "CRA domain [IPR013144]", "CRAL-TRIO lipid binding domain [IPR001251]", "CRIB domain [IPR000095]", "CRK, C-terminal SH3 domain [IPR035458]", "CRK, N-terminal SH3 domain [IPR035457]", "CS domain [IPR007052]", "CSK-like, SH2 domain [IPR035027]", "CSN8/PSMD8/EIF3K [IPR033464]", "CTLH, C-terminal LisH motif [IPR006595]", "CTLH/CRA C-terminal to LisH motif domain [IPR024964]", "CTP synthase GATase domain [IPR033828]", "CTP synthase, N-terminal [IPR017456]", "CYRIA/CYRIB, Rac1 binding domain [IPR009828]", "Cadherin-like [IPR002126]", "Calcineurin-like phosphoesterase domain, ApaH type [IPR004843]", "Calcineurin-like phosphoesterase domain, lpxH-type [IPR024654]", "Calcium uniporter protein, C-terminal [IPR006769]", "Calcium/calmodulin-dependent protein kinase II, association-domain [IPR013543]", "Calcyclin-binding Protein, CS domain [IPR037893]", "Calpain subdomain III [IPR033883]", "Calponin homology domain [IPR001715]", "Caprin-1 dimerization domain [IPR041637]", "Carbamoyl-phosphate synthase large subunit, CPSase domain [IPR005483]", "Carbamoyl-phosphate synthase small subunit, GATase1 domain [IPR035686]", "Carbamoyl-phosphate synthase small subunit, N-terminal domain [IPR002474]", "Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain [IPR005479]", "Carbamoyl-phosphate synthetase, large subunit oligomerisation domain [IPR005480]", "Carbohydrate kinase PfkB [IPR011611]", "Carboxylase, conserved domain [IPR003379]", "Carboxypeptidase D, carboxypeptidase-like domain 2 [IPR034224]", "Carboxypeptidase D, carboxypeptidase-like domain 3 [IPR033848]", "Carnitine O-palmitoyltransferase, N-terminal [IPR032476]", "Casein kinase substrate, phosphoprotein PP28 [IPR019380]", "Caspase recruitment domain [IPR031964]", "Cathepsin C [IPR039412]", "Cathepsin C exclusion [IPR014882]", "Cation-transporting P-type ATPase, C-terminal [IPR006068]", "Cation-transporting P-type ATPase, N-terminal [IPR004014]", "Cationic amino acid transporter, C-terminal [IPR029485]", "Caudal-like activation domain [IPR006820]", "Cdc23 [IPR007192]", "Cdc37, C-terminal [IPR013873]", "Cdc37, Hsp90 binding [IPR013874]", "Cdc37, N-terminal domain [IPR013855]", "Cell division control protein 73, C-terminal [IPR031336]", "Cell morphogenesis central region [IPR029473]", "Cell morphogenesis protein C-terminal [IPR025481]", "Cell morphogenesis protein N-terminal [IPR025614]", "Cellular tumor antigen p53, transactivation domain 2 [IPR040926]", "Centrosomal CEP44 domain [IPR029157]", "Centrosomin, N-terminal motif 1 [IPR012943]", "Chaperone DnaJ, C-terminal [IPR002939]", "Chitinase II [IPR011583]", "Choline/carnitine acyltransferase domain [IPR039551]", "Choloylglycine hydrolase/NAAA C-terminal [IPR029132]", "Chromatin assembly factor 1 subunit B, C-terminal domain [IPR029129]", "Chromatin target of PRMT1 protein, C-terminal [IPR025715]", "Chromo domain [IPR023780]", "Chromo domain subgroup [IPR017984]", "Chromo shadow domain [IPR008251]", "Chromo/chromo shadow domain [IPR000953]", "Chromosome segregation protein Spc25, C-terminal [IPR013255]", "Circularly permuted (CP)-type guanine nucleotide-binding (G) domain [IPR030378]", "Class I myosin tail homology domain [IPR010926]", "Class I myosin, motor domain [IPR036072]", "Class II PurE [IPR033626]", "Class II aldolase/adducin N-terminal [IPR001303]", "Class VI myosin, motor domain [IPR036114]", "Clathrin adaptor, alpha-adaptin, appendage, C-terminal subdomain [IPR003164]", "Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain [IPR008152]", "Clathrin, heavy chain, linker, core motif [IPR015348]", "Clathrin/coatomer adaptor, adaptin-like, N-terminal [IPR002553]", "Cleavage and polyadenylation specificity factor 2, C-terminal [IPR025069]", "Cleavage stimulation factor subunit 1, dimerisation domain [IPR032028]", "Cleavage stimulation factor subunit 2, hinge domain [IPR025742]", "Cleavage/polyadenylation specificity factor, A subunit, C-terminal [IPR004871]", "Cleavage/polyadenylation specificity factor, A subunit, N-terminal [IPR018846]", "Clp ATPase, C-terminal [IPR019489]", "Clustered mitochondria protein, N-terminal [IPR028275]", "Cns1/TTC4, wheel domain [IPR044059]", "CoA-binding [IPR003781]", "Coatomer beta subunit, C-terminal [IPR011710]", "Coatomer beta subunit, appendage platform domain [IPR029446]", "Coatomer subunit gamma, C-terminal [IPR032154]", "Coatomer, WD associated region [IPR006692]", "Coatomer, alpha subunit, C-terminal [IPR010714]", "Coatomer, gamma subunit, appendage, Ig-like subdomain [IPR013040]", "Cobalamin (vitamin B12)-binding domain [IPR006158]", "Cobalamin (vitamin B12)-binding module, cap domain [IPR003759]", "Cobalamin adenosyltransferase-like [IPR016030]", "Coilin, N-terminal domain [IPR031722]", "Cold shock domain [IPR011129]", "Cold-shock (CSD) domain [IPR019844]", "Cold-shock protein, DNA-binding [IPR002059]", "Complex 1 LYR protein domain [IPR008011]", "Condensin complex subunit 1, C-terminal [IPR032682]", "Condensin complex subunit 1, N-terminal [IPR024324]", "Conserved oligomeric Golgi complex, subunit 2, N-terminal [IPR024602]", "Cop9 signalosome subunit 5 C-terminal domain [IPR040961]", "Copine, C-terminal [IPR010734]", "Copine, C2B domain [IPR037768]", "Core histone macro-H2A, macro domain [IPR035796]", "Cortactin, SH3 domain [IPR035716]", "Creatinase, N-terminal [IPR000587]", "Cro/C1-type helix-turn-helix domain [IPR001387]", "Cullin homology domain [IPR016158]", "Cullin protein, neddylation domain [IPR019559]", "Cullin, N-terminal [IPR001373]", "Cwf19-like protein, C-terminal domain-2 [IPR006767]", "Cwf19-like, C-terminal domain-1 [IPR006768]", "Cyclic nucleotide-binding domain [IPR000595]", "Cyclin, C-terminal domain [IPR004367]", "Cyclin, N-terminal [IPR006671]", "Cyclin-like [IPR013763]", "Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain [IPR002130]", "Cystatin domain [IPR000010]", "Cysteine-rich flanking region, C-terminal [IPR000483]", "Cystine knot, C-terminal [IPR006207]", "Cytidine and deoxycytidylate deaminase domain [IPR002125]", "Cytidyltransferase-like domain [IPR004821]", "Cytochrome C oxidase subunit II, transmembrane domain [IPR011759]", "Cytochrome b5-like heme/steroid binding domain [IPR001199]", "Cytochrome c oxidase assembly factor 3, mitochondrial, coiled-coil domain [IPR018628]", "Cytochrome c oxidase subunit 2, C-terminal [IPR034210]", "Cytochrome c oxidase subunit II-like C-terminal [IPR002429]", "Cytochrome c oxidase, subunit II [IPR014222]", "Cytoplasmic activation/proliferation-associated protein-1 C term [IPR022070]", "Cytoskeleton-associated protein 2, C-terminal [IPR029197]", "Cytosolic fatty-acid binding [IPR000463]", "D-3-phosphoglycerate dehydrogenase, ASB domain [IPR045626]", "D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain [IPR006140]", "D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain [IPR006139]", "DALR anticodon binding [IPR008909]", "DAZ-associated protein 1, RNA recognition motif 1 [IPR034134]", "DAZ-associated protein 1, RNA recognition motif 2 [IPR034131]", "DBC1/CARP1 catalytically inactive NUDIX hydrolase domain [IPR025954]", "DBINO domain [IPR020838]", "DBP10, C-terminal [IPR012541]", "DDE superfamily endonuclease domain [IPR004875]", "DDHD domain [IPR004177]", "DDT domain [IPR018501]", "DDX18/Has1, DEAD-box helicase domain [IPR044773]", "DDX41, DEAD-box helicase domain [IPR044113]", "DDX47/Rrp3, DEAD-box helicase domain [IPR044765]", "DDX52/Rok1, DEAD-box helicase domain [IPR044764]", "DEAD box protein 17, ATP-binding domain [IPR046330]", "DEAD/DEAH box helicase domain [IPR011545]", "DEAD2 [IPR010614]", "DEK, C-terminal [IPR014876]", "DExH-box ATP-dependent RNA helicase, R3H domain [IPR034083]", "DFDF domain [IPR025762]", "DHHA1 domain [IPR003156]", "DHX15, DEXH-box helicase domain [IPR044756]", "DHX8/ Prp22, DEXH-box helicase domain [IPR044762]", "DHX9, DEXH-box helicase domain [IPR044447]", "DHX9, first double-stranded RNA binding domain [IPR044445]", "DHX9, second double-stranded RNA binding domain [IPR044446]", "DJ-1/PfpI [IPR002818]", "DMAP1-binding domain [IPR010506]", "DML1/Misato, tubulin domain [IPR029209]", "DNA (cytosine-5)-methyltransferase 1, replication foci domain [IPR022702]", "DNA damage inducible protein 1 ubiquitin-like domain [IPR033882]", "DNA fragmentation factor 45kDa, middle domain [IPR015121]", "DNA ligase 3, BRCT domain [IPR031916]", "DNA ligase, ATP-dependent, C-terminal [IPR012309]", "DNA ligase, ATP-dependent, N-terminal [IPR012308]", "DNA ligase, ATP-dependent, central [IPR012310]", "DNA mismatch repair protein MutS, C-terminal [IPR000432]", "DNA mismatch repair protein MutS, clamp [IPR007861]", "DNA mismatch repair protein MutS, connector domain [IPR007860]", "DNA mismatch repair protein MutS, core [IPR007696]", "DNA mismatch repair protein MutS-like, N-terminal [IPR007695]", "DNA polymerase alpha catalytic subunit, N-terminal domain [IPR024647]", "DNA polymerase alpha catalytic subunit, catalytic domain [IPR045846]", "DNA polymerase alpha, subunit B, N-terminal [IPR013627]", "DNA polymerase alpha/delta/epsilon, subunit B [IPR007185]", "DNA polymerase epsilon, catalytic subunit A, C-terminal [IPR013697]", "DNA repair Nbs1, C-terminal [IPR013908]", "DNA replication complex GINS protein SLD5, C-terminal [IPR031633]", "DNA replication factor RFC1, C-terminal [IPR013725]", "DNA topoisomerase 2, TOPRIM domain [IPR034157]", "DNA topoisomerase I, DNA binding, eukaryotic-type [IPR008336]", "DNA topoisomerase I, catalytic core, eukaryotic-type [IPR013500]", "DNA topoisomerase I, eukaryotic-type [IPR013499]", "DNA topoisomerase, type IIA, domain A [IPR002205]", "DNA topoisomerase, type IIA, subunit B, domain 2 [IPR013506]", "DNA-binding RFX-type winged-helix domain [IPR003150]", "DNA-dependent protein kinase catalytic subunit, CC3 [IPR012582]", "DNA-dependent protein kinase catalytic subunit, CC5 [IPR045581]", "DNA-dependent protein kinase catalytic subunit, catalytic domain [IPR037706]", "DNA-directed DNA polymerase, family B, exonuclease domain [IPR006133]", "DNA-directed DNA polymerase, family B, multifunctional domain [IPR006134]", "DNA-directed RNA polymerase I subunit RPA2, domain 4 [IPR009674]", "DNA-directed RNA polymerase III subunit RPC1, C-terminal [IPR035698]", "DNA-directed RNA polymerase III subunit RPC1, N-terminal [IPR035697]", "DNA-directed RNA polymerase, N-terminal [IPR029262]", "DNA-directed RNA polymerase, RpoA/D/Rpb3-type [IPR011263]", "DNA-directed RNA polymerase, insert domain [IPR011262]", "DNA-directed RNA polymerase, subunit 2, hybrid-binding domain [IPR007120]", "DNA-repair protein Xrcc1, N-terminal [IPR002706]", "DNA/RNA non-specific endonuclease [IPR001604]", "DNA2/NAM7 helicase, helicase domain [IPR041677]", "DNA2/NAM7 helicase-like, C-terminal [IPR041679]", "DOCKER domain [IPR027357]", "DPF1-3, N-terminal domain [IPR025750]", "DSBA-like thioredoxin domain [IPR001853]", "DTHCT [IPR012542]", "DWNN domain [IPR014891]", "DZF domain [IPR006561]", "Damage-control phosphatase ARMT1-like, metal-binding domain [IPR002791]", "Dbl homology (DH) domain [IPR000219]", "Death domain [IPR000488]", "Death effector domain [IPR001875]", "Dedicator of cytokinesis C, C2 domain [IPR037808]", "Dedicator of cytokinesis C/D, N-terminal [IPR021816]", "Dehydrogenase, E1 component [IPR001017]", "Deoxycytidylate deaminase domain [IPR035105]", "Deoxynucleoside kinase domain [IPR031314]", "Desmoplakin, SH3 domain [IPR041615]", "Desmoplakin, spectrin-like domain [IPR041573]", "DhaK domain [IPR004006]", "DhaL domain [IPR004007]", "Diacylglycerol kinase, catalytic domain [IPR001206]", "Diaphanous autoregulatory (DAD) domain [IPR014767]", "Dicer dimerisation domain [IPR005034]", "Dicer, double-stranded RNA-binding domain [IPR044441]", "Dihydrofolate reductase domain [IPR001796]", "Dilute domain [IPR002710]", "Dip2-like domain [IPR037337]", "Dipeptidyl peptidase 8 /9 ,N-terminal [IPR045785]", "Dipeptidylpeptidase IV, N-terminal domain [IPR002469]", "Dis3-like cold-shock domain 2 [IPR041505]", "Disulphide isomerase [IPR005788]", "DnaJ domain [IPR001623]", "DnaJ-like protein C11, C-terminal [IPR024586]", "Dolichyldiphosphatase, PAP2 domain [IPR039667]", "Domain of unknown function DUF1087 [IPR009463]", "Domain of unknown function DUF1115 [IPR010541]", "Domain of unknown function DUF1605 [IPR011709]", "Domain of unknown function DUF1747 [IPR013719]", "Domain of unknown function DUF1899 [IPR015048]", "Domain of unknown function DUF3350 [IPR021785]", "Domain of unknown function DUF3385, target of rapamycin protein [IPR024585]", "Domain of unknown function DUF3456 [IPR021852]", "Domain of unknown function DUF3480 [IPR022557]", "Domain of unknown function DUF3517 [IPR021905]", "Domain of unknown function DUF382 [IPR007180]", "Domain of unknown function DUF4042 [IPR025283]", "Domain of unknown function DUF4149 [IPR025423]", "Domain of unknown function DUF4208 [IPR025260]", "Domain of unknown function DUF4217 [IPR025313]", "Domain of unknown function DUF4749 [IPR031847]", "Domain of unknown function DUF5600 [IPR040990]", "Domain of unknown function DUF625 [IPR006887]", "Double-stranded RNA-binding domain [IPR014720]", "Down-regulated-in-metastasis protein [IPR011430]", "Drebrin-like protein, SH3 domain [IPR035717]", "Dual specificity phosphatase, catalytic domain [IPR000340]", "Dual specificity protein phosphatase domain [IPR020422]", "Dullard phosphatase domain, eukaryotic [IPR011948]", "Dynamin GTPase effector [IPR003130]", "Dynamin stalk domain [IPR000375]", "Dynamin, GTPase domain [IPR001401]", "Dynamin, N-terminal [IPR045063]", "Dynamin-like GTPase OPA1, C-terminal [IPR045817]", "Dynamin-type guanine nucleotide-binding (G) domain [IPR030381]", "Dynein associated protein [IPR022157]", "Dynein heavy chain AAA lid domain [IPR041658]", "Dynein heavy chain region D6 P-loop domain [IPR004273]", "Dynein heavy chain, AAA 5 extension domain [IPR041466]", "Dynein heavy chain, AAA module D4 [IPR024317]", "Dynein heavy chain, ATP-binding dynein motor region [IPR035706]", "Dynein heavy chain, C-terminal domain [IPR041228]", "Dynein heavy chain, coiled coil stalk [IPR024743]", "Dynein heavy chain, hydrolytic ATP-binding dynein motor region [IPR035699]", "Dynein heavy chain, linker [IPR013602]", "Dynein heavy chain, tail [IPR013594]", "Dyskerin-like [IPR012960]", "E2 binding [IPR014929]", "E3 ligase, CCCH-type zinc finger [IPR041367]", "E3 ubiquitin ligase EDD, ubiquitin-associated domain [IPR024725]", "E3 ubiquitin ligase UBR4, C-terminal [IPR025704]", "E3 ubiquitin ligase, domain of unknown function DUF908 [IPR010309]", "E3 ubiquitin ligase, domain of unknown function DUF913 [IPR010314]", "E3 ubiquitin-protein ligase UBR4, N-terminal [IPR045841]", "EB-1 binding [IPR009232]", "EB1, C-terminal [IPR004953]", "EBP50, C-terminal [IPR015098]", "ECSIT, C-terminal domain [IPR029342]", "EF hand associated, type-1 [IPR013566]", "EF hand associated, type-2 [IPR013567]", "EF-hand domain [IPR002048]", "EF-hand domain, type 1 [IPR015153]", "EF-hand domain, type 2 [IPR015154]", "EF-hand, Ca insensitive [IPR014837]", "EFG, domain V [IPR035649]", "EGF-like calcium-binding domain [IPR001881]", "EGF-like domain [IPR000742]", "EGF-like domain, extracellular [IPR013111]", "EH domain [IPR000261]", "EH domain-containing protein, N-terminal [IPR031692]", "EIF2AK2, first double-stranded RNA binding domain [IPR044452]", "EIF2AK2, second double-stranded RNA binding domain [IPR044453]", "ELM2 domain [IPR000949]", "ELYS, beta-propeller domain [IPR032040]", "ELYS-like domain [IPR025151]", "ENTH domain [IPR013809]", "ER membrane protein complex subunit 1, C-terminal [IPR011678]", "ERAP1-like C-terminal domain [IPR024571]", "ERCC3/RAD25/XPB helicase, C-terminal domain [IPR032438]", "ERM family, FERM domain C-lobe [IPR041789]", "ERdj5, C-terminal thioredoxin domain [IPR035674]", "ERdj5, first thioredoxin domain [IPR035673]", "ERp29, N-terminal [IPR012883]", "EWS, RNA recognition motif [IPR034869]", "EXPERA domain [IPR033118]", "Electron transfer flavoprotein, alpha subunit, C-terminal [IPR014731]", "Electron transfer flavoprotein, alpha subunit, N-terminal [IPR033947]", "Electron transfer flavoprotein, alpha/beta-subunit, N-terminal [IPR014730]", "Electron transfer flavoprotein, beta subunit, N-terminal [IPR033948]", "Elongation Factor G, domain II [IPR041095]", "Elongation factor 1 beta central acidic region, eukaryote [IPR018940]", "Elongation factor 1B gamma, C-terminal [IPR001662]", "Elongation factor EFG, domain V-like [IPR000640]", "Elongation factor G, domain III [IPR009022]", "Elongation factor Tu (EF-Tu), GTP-binding domain [IPR041709]", "Elongation factor Tu, domain 2 [IPR033720]", "Elp3/MiaB/NifB [IPR006638]", "Emerin, LEM domain [IPR034989]", "Endonuclease/exonuclease/phosphatase [IPR005135]", "Endophilin B2, SH3 domain [IPR035640]", "Endophilin-A, SH3 domain [IPR035824]", "Endophilin-B1, BAR domain [IPR035695]", "Endoplasmic reticulum resident protein 29, C-terminal [IPR011679]", "Endoplasmic reticulum resident protein 44, TRX-like domain b [IPR041870]", "Endoplasmic reticulum resident protein 44, TRX-like domain b' [IPR041862]", "Endoplasmic reticulum vesicle transporter, C-terminal [IPR012936]", "Endoplasmic reticulum vesicle transporter, N-terminal [IPR039542]", "Enhancer of mRNA-decapping protein 4, WD40 repeat region [IPR032401]", "Enolase, C-terminal TIM barrel domain [IPR020810]", "Enolase, N-terminal [IPR020811]", "Enoyl-CoA hydratase/isomerase domain [IPR045004]", "Era-type guanine nucleotide-binding (G) domain [IPR030388]", "Eukaryotic Ribosomal Protein L27, KOW domain [IPR041991]", "Eukaryotic glycogen debranching enzyme, N-terminal domain [IPR029436]", "Eukaryotic translation initiation factor 2D, SUI1 domain [IPR039759]", "Eukaryotic translation initiation factor 3 subunit E, N-terminal [IPR019010]", "Eukaryotic translation initiation factor 3 subunit G, N-terminal [IPR024675]", "Exocyst complex component EXOC2/Sec5, N-terminal domain [IPR039481]", "Exocyst complex component Sec3, C-terminal [IPR019160]", "Exocyst complex component Sec3, PIP2-binding N-terminal domain [IPR028258]", "Exonuclease 1-like, PIN-like domain [IPR044752]", "Exonuclease, RNase T/DNA polymerase III [IPR013520]", "Exonuclease-1, H3TH domain [IPR037315]", "Exoribonuclease, phosphorolytic domain 1 [IPR001247]", "Exoribonuclease, phosphorolytic domain 2 [IPR015847]", "Exosome complex exonuclease RRP44, S1 domain [IPR033770]", "Exosome-associated factor Rrp6, N-terminal [IPR012588]", "Exportin-1, C-terminal [IPR014877]", "Exportin-1/Importin-beta-like [IPR013598]", "Exportin-2, C-terminal [IPR005043]", "Exportin-2, central domain [IPR013713]", "Exportin-5, C-terminal domain [IPR045478]", "Exportin-T, C-terminal domain [IPR045546]", "Extended PHD (ePHD) domain [IPR034732]", "Extended synaptotagmin, C-terminal C2 domain [IPR037752]", "Extended synaptotagmin, C2A domain [IPR037733]", "Extended synaptotagmin, C2B domain [IPR037749]", "Extracellular Endonuclease, subunit A [IPR020821]", "F-BAR domain [IPR031160]", "F-box domain [IPR001810]", "FACT complex subunit POB3-like, N-terminal PH domain [IPR035417]", "FACT complex subunit Spt16 domain [IPR013953]", "FACT complex subunit Spt16, N-terminal lobe domain [IPR029148]", "FACT complex subunit Spt16, peptidase M24-like domain [IPR033825]", "FAD dependent oxidoreductase [IPR006076]", "FAD linked oxidase, N-terminal [IPR006094]", "FAD-binding domain, PCMH-type [IPR016166]", "FAD-binding domain, ferredoxin reductase-type [IPR017927]", "FAD-dependent oxidoreductase 2, FAD binding domain [IPR003953]", "FAD-linked oxidase, C-terminal [IPR004113]", "FAD/NAD(P)-binding domain [IPR023753]", "FAF1, UBA-like domain [IPR044541]", "FAM3C (ILEI) domain [IPR039475]", "FAM91, C-terminal domain [IPR028097]", "FAM91, N-terminal domain [IPR028091]", "FANCI helical domain 1 [IPR029310]", "FANCI helical domain 2 [IPR029312]", "FANCI solenoid 1 cap [IPR029305]", "FANCI solenoid 1 domain [IPR029308]", "FANCI solenoid 2 domain [IPR029315]", "FANCI solenoid 3 domain [IPR029313]", "FANCI solenoid 4 domain [IPR029314]", "FAS-associated factor 1-like, UBX domain [IPR033043]", "FAST kinase leucine-rich [IPR010622]", "FAST kinase-like protein, subdomain 2 [IPR013579]", "FATC domain [IPR003152]", "FCH domain [IPR001060]", "FCP1 homology domain [IPR004274]", "FDF domain [IPR019050]", "FERM adjacent (FA) [IPR014847]", "FERM central domain [IPR019748]", "FERM domain [IPR000299]", "FERM, C-terminal PH-like domain [IPR018980]", "FERM, N-terminal [IPR018979]", "FF domain [IPR002713]", "FGFR1 oncogene partner (FOP), N-terminal dimerisation domain [IPR018993]", "FHOD1, N-terminal GTPase-binding domain [IPR041387]", "FIST, C-domain [IPR019494]", "FKBP-type peptidyl-prolyl cis-trans isomerase domain [IPR001179]", "FKBP12-rapamycin binding domain [IPR009076]", "FKBP3, basic tilted helix bundle domain [IPR041200]", "FYVE zinc finger [IPR000306]", "Far upstream element-binding protein, C-terminal [IPR015096]", "Fascin domain [IPR022768]", "Fatty acid desaturase domain [IPR005804]", "Fatty acid hydroxylase [IPR006694]", "Fatty acyl-CoA reductase, C-terminal [IPR033640]", "Fatty acyl-coenzyme A reductase, NAD-binding domain [IPR013120]", "Fcf2 pre-rRNA processing, C-terminal [IPR014810]", "Ferrochelatase, C-terminal [IPR033644]", "Ferrochelatase, N-terminal [IPR033659]", "Fibronectin type II domain [IPR000562]", "Fibronectin type III [IPR003961]", "First polo-box domain [IPR033701]", "Flavodoxin-like [IPR001094]", "Flavodoxin/nitric oxide synthase [IPR008254]", "Flavoprotein pyridine nucleotide cytochrome reductase [IPR001709]", "Flavoprotein pyridine nucleotide cytochrome reductase-like, FAD-binding domain [IPR008333]", "Follistatin-like, N-terminal [IPR003645]", "Fork head domain [IPR001766]", "Forkhead-associated (FHA) domain [IPR000253]", "Formin, FH2 domain [IPR015425]", "Formin, FH3 domain [IPR010472]", "Formin, GTPase-binding domain [IPR010473]", "Formyl transferase, N-terminal [IPR002376]", "Fragile X-related 1 protein, C-terminal core [IPR022034]", "Fragile X-related 1 protein, C-terminal region 1 [IPR032172]", "Fragile X-related 1 protein, C-terminal region 3 [IPR032177]", "Fragile X-related mental retardation protein, C-terminal region 2 [IPR032196]", "Fumarase C, C-terminal [IPR018951]", "Fumarate lyase, N-terminal [IPR022761]", "Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal [IPR015939]", "Fumarylacetoacetase, N-terminal [IPR015377]", "Fumarylacetoacetase-like, C-terminal [IPR011234]", "Fungal lipase-like domain [IPR002921]", "Fxr1, tudor domain [IPR041560]", "Fzo/mitofusin HR2 domain [IPR006884]", "G-patch domain [IPR000467]", "G-patch domain and KOW motifs-containing protein, KOW 1 [IPR041993]", "G-patch domain and KOW motifs-containing protein, KOW 2 [IPR041994]", "G-protein, beta subunit [IPR001632]", "G3BP1, RNA recognition motif [IPR034374]", "G3BP2, RNA recognition motif [IPR034376]", "GAD domain [IPR029351]", "GAR domain [IPR003108]", "GAT domain [IPR004152]", "GB1/RHD3-type guanine nucleotide-binding (G) domain [IPR030386]", "GCC2, Rab binding domain [IPR032023]", "GHMP kinase N-terminal domain [IPR006204]", "GHMP kinase, C-terminal domain [IPR013750]", "GINS complex protein Sld5, alpha-helical domain [IPR038749]", "GINS subunit, domain A [IPR021151]", "GMP phosphodiesterase, delta subunit [IPR008015]", "GMP synthase, C-terminal [IPR001674]", "GMP synthase, glutamine amidotransferase [IPR004739]", "GMP synthetase ATP pyrophosphatase domain [IPR025777]", "GNAT domain [IPR000182]", "GOLD domain [IPR009038]", "GPAT/DHAPAT, acyltransferase domain [IPR041728]", "GPR domain [IPR000965]", "GRAM domain [IPR004182]", "GRASP-type PDZ domain [IPR024958]", "GRB2, C-terminal SH3 domain [IPR035643]", "GRB2, N-terminal SH3 domain [IPR035641]", "GRIP domain [IPR000237]", "GRSF-1, RNA recognition motif 1 [IPR034425]", "GRSF-1, RNA recognition motif 2 [IPR034424]", "GRSF-1, RNA recognition motif 3 [IPR034426]", "GTP binding domain [IPR006073]", "GTP binding protein 1-like, GTP-binding domain [IPR035531]", "GTP binding protein, second domain [IPR031662]", "GTP-binding protein TrmE, N-terminal [IPR018948]", "GTP1/OBG domain [IPR006169]", "GTPase effector domain [IPR020850]", "GUCT [IPR012562]", "GYF domain [IPR003169]", "Galactokinase, N-terminal domain [IPR019539]", "Galactose mutarotase, N-terminal barrel [IPR031727]", "Galectin, carbohydrate recognition domain [IPR001079]", "Gamma tubulin complex component protein, N-terminal [IPR041470]", "Gamma tubulin complex component, C-terminal [IPR040457]", "Gamma-adaptin ear (GAE) domain [IPR008153]", "Gamma-glutamyl cyclotransferase-like [IPR013024]", "Gcp-like domain [IPR000905]", "Gelsolin-like domain [IPR007123]", "Gfo/Idh/MocA-like oxidoreductase, N-terminal [IPR000683]", "GlmS/AgaS, SIS domain 1 [IPR035466]", "GlmS/FrlB, SIS domain 2 [IPR035490]", "Glucosamine/galactosamine-6-phosphate isomerase [IPR006148]", "Glucose-6-phosphate dehydrogenase, C-terminal [IPR022675]", "Glucose-6-phosphate dehydrogenase, NAD-binding [IPR022674]", "Glucosidase 2 subunit beta-like [IPR036607]", "Glucosidase II beta subunit, N-terminal [IPR028146]", "Glucosyltransferase 24, catalytic domain [IPR040497]", "Glutamate/phenylalanine/leucine/valine dehydrogenase, C-terminal [IPR006096]", "Glutamate/phenylalanine/leucine/valine dehydrogenase, dimerisation domain [IPR006097]", "Glutaminase, EF-hand domain [IPR041541]", "Glutamine amidotransferase [IPR017926]", "Glutamine amidotransferase type 2 domain [IPR017932]", "Glutamine-Leucine-Glutamine, QLQ [IPR014978]", "Glutaminyl-tRNA synthetase, class Ib, non-specific RNA-binding domain 2 [IPR007638]", "Glutaminyl-tRNA synthetase, class Ib, non-specific RNA-binding domain, N-terminal [IPR007639]", "Glutamyl-tRNA synthetase [IPR033910]", "Glutamyl/glutaminyl-tRNA synthetase, class Ib, anti-codon binding domain [IPR020059]", "Glutamyl/glutaminyl-tRNA synthetase, class Ib, catalytic domain [IPR020058]", "Glutaredoxin [IPR002109]", "Glutaredoxin, PICOT-like [IPR033658]", "Glutathione S-transferase, C-terminal [IPR004046]", "Glutathione S-transferase, C-terminal-like [IPR010987]", "Glutathione S-transferase, N-terminal [IPR004045]", "Glutathione S-transferases, class Zeta , C-terminal [IPR034330]", "Glutathione S-transferases, class Zeta , N-terminal [IPR034333]", "Glutathione synthase, substrate-binding domain [IPR004887]", "Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain [IPR020828]", "Glyceraldehyde 3-phosphate dehydrogenase, catalytic domain [IPR020829]", "Glycerol-3-phosphate acyltransferase-like, C-terminal domain [IPR045520]", "Glycerophosphodiester phosphodiesterase domain [IPR030395]", "Glycogen debranching enzyme, C-terminal [IPR032790]", "Glycogen debranching enzyme, central domain [IPR032788]", "Glycogen debranching enzyme, glucanotransferase domain [IPR032792]", "Glycogen synthase kinase 3, catalytic domain [IPR039192]", "Glycoside hydrolase 35, catalytic domain [IPR031330]", "Glycoside hydrolase family 18, catalytic domain [IPR001223]", "Glycoside hydrolase family 2, catalytic domain [IPR006103]", "Glycoside hydrolase family 20, catalytic domain [IPR015883]", "Glycoside hydrolase family 31, N-terminal domain [IPR025887]", "Glycoside hydrolase, family 13, N-terminal [IPR004193]", "Glycoside hydrolase, family 2, immunoglobulin-like beta-sandwich [IPR006102]", "Glycosyl hydrolase family 30, TIM-barrel domain [IPR033453]", "Glycosyl hydrolase family 30, beta sandwich domain [IPR033452]", "Glycosyl hydrolase family 63, C-terminal [IPR031335]", "Glycosyl hydrolase family 63, N-terminal [IPR031631]", "Glycosyl hydrolase, family 13, catalytic domain [IPR006047]", "Glycosyl hydrolases family 2, sugar binding domain [IPR006104]", "Glycosyl transferase CAP10 domain [IPR006598]", "Glycosyl transferase, family 1 [IPR001296]", "Glycosyltransferase 2-like [IPR001173]", "Glycyl-tRNA synthetase-like core domain [IPR033731]", "Glyoxalase domain-containing protein 4, C-terminal [IPR043194]", "Glyoxalase/fosfomycin resistance/dioxygenase domain [IPR004360]", "Golgi pH regulator, conserved domain [IPR022535]", "Growth hormone-inducible transmembrane protein [IPR035871]", "Guanine nucleotide exchange factor, N-terminal [IPR032691]", "Guanine nucleotide-binding protein-like 3, N-terminal domain [IPR014813]", "Guanylate kinase-like domain [IPR008144]", "Guanylate kinase/L-type calcium channel beta subunit [IPR008145]", "Guanylate-binding protein, N-terminal [IPR015894]", "Guanylate-binding protein/Atlastin, C-terminal [IPR003191]", "HAD-superfamily hydrolase, subfamily IIID [IPR011943]", "HBS1-like protein, N-terminal [IPR015033]", "HD domain [IPR006674]", "HD/PDEase domain [IPR003607]", "HDGF-related, PWWP domain [IPR035496]", "HECT domain [IPR000569]", "HELLS, N-terminal [IPR044753]", "HELP [IPR005108]", "HHH domain 9 [IPR041692]", "HIRAN domain [IPR014905]", "HIT-like domain [IPR011146]", "HOOK, N-terminal [IPR043936]", "HORMA domain [IPR003511]", "HR1 rho-binding domain [IPR011072]", "HRDC domain [IPR002121]", "HSPA4, nucleotide-binding domain [IPR042052]", "HSPA4L, nucleotide-binding domain [IPR042708]", "HSPH1, nucleotide-binding domain [IPR042053]", "HTH CenpB-type DNA-binding domain [IPR006600]", "HTTM [IPR011020]", "HUWE1, UBA domain [IPR041918]", "Heat shock 70kDa protein 14, nucleotide-binding domain [IPR042049]", "Heat shock chaperonin-binding [IPR006636]", "Heat shock protein DnaJ, cysteine-rich domain [IPR001305]", "Heat shock protein Hsp90, N-terminal [IPR020575]", "Heat shock protein beta-1, ACD domain [IPR037876]", "Helical and beta-bridge domain [IPR010643]", "Helicase XPB/Ssl2, N-terminal domain [IPR032830]", "Helicase domain [IPR007807]", "Helicase superfamily 1/2, ATP-binding domain [IPR014001]", "Helicase superfamily 1/2, ATP-binding domain, DinG/Rad3-type [IPR014013]", "Helicase, C-terminal [IPR001650]", "Helicase-associated domain [IPR007502]", "Helicase-like, DEXD box c2 type [IPR006554]", "Helicase/SANT-associated domain [IPR014012]", "Helicase/UvrB, N-terminal [IPR006935]", "Helix-hairpin-helix DNA-binding motif, class 1 [IPR003583]", "Helix-turn-helix DNA-binding domain of Spt6 [IPR028088]", "Hemimethylated DNA-binding domain [IPR011722]", "Hepatitis delta antigen (HDAg) domain [IPR037517]", "Hepatocyte growth factor-regulated tyrosine kinase substrate, helical domain [IPR024641]", "Heterogeneous nuclear ribonucleoprotein Q acidic domain [IPR041337]", "Heterogeneous nuclear ribonucleoprotein Q, RNA recognition motif 1 [IPR034544]", "Heterogeneous nuclear ribonucleoprotein Q, RNA recognition motif 2 [IPR034548]", "Heterogeneous nuclear ribonucleoprotein R, RNA recognition motif 2 [IPR034411]", "Heterogeneous nuclear ribonucleoprotein U, SPRY domain [IPR035778]", "Hexokinase, C-terminal [IPR022673]", "Hexokinase, N-terminal [IPR022672]", "High mobility group box domain 5 [IPR029215]", "High mobility group box domain [IPR009071]", "Histidine kinase domain [IPR005467]", "Histidine kinase/HSP90-like ATPase [IPR003594]", "Histone H2A, C-terminal domain [IPR032454]", "Histone H2A/H2B/H3 [IPR007125]", "Histone acetyl transferase HAT1 N-terminal [IPR019467]", "Histone acetyltransferase domain, MYST-type [IPR002717]", "Histone deacetylase complex subunit SAP130, C-terminal domain [IPR031963]", "Histone deacetylase domain [IPR023801]", "Histone-arginine methyltransferase CARM1, N-terminal [IPR020989]", "Histone-binding protein RBBP4, N-terminal [IPR022052]", "HnRNP M, nuclear localisation signal [IPR024666]", "Homeobox domain [IPR001356]", "Homeobox domain, metazoa [IPR020479]", "Homocysteine-binding domain [IPR003726]", "Hook, C-terminal [IPR008636]", "Hotdog acyl-CoA thioesterase (ACOT)-type domain [IPR033120]", "HuR, RNA recognition motif 2 [IPR034996]", "Hyaluronan/mRNA-binding protein [IPR006861]", "Hydroxymethylglutaryl-coenzyme A synthase, C-terminal domain [IPR013746]", "Hydroxymethylglutaryl-coenzyme A synthase, N-terminal [IPR013528]", "I/LWEQ domain [IPR002558]", "IBR domain [IPR002867]", "IF2a, S1-like domain [IPR044126]", "IGF2BP1, RNA recognition motif 1 [IPR034837]", "IGF2BP1, RNA recognition motif 2 [IPR034842]", "IGF2BP2, RNA recognition motif 1 [IPR034843]", "IGF2BP3, RNA recognition motif 2 [IPR034844]", "ILEI/PANDER domain [IPR039477]", "IMD/I-BAR domain [IPR013606]", "IMP dehydrogenase/GMP reductase [IPR001093]", "IPS1, CARD domain [IPR042144]", "IPT domain [IPR002909]", "IRG-type guanine nucleotide-binding (G) domain [IPR030385]", "IRS-type PTB domain [IPR002404]", "IRSp53, SH3 domain [IPR035594]", "ISWI, HAND domain [IPR015194]", "Ima1, N-terminal domain [IPR018617]", "Immunoglobulin C1-set [IPR003597]", "Immunoglobulin I-set [IPR013098]", "Immunoglobulin V-set domain [IPR013106]", "Immunoglobulin subtype 2 [IPR003598]", "Immunoglobulin subtype [IPR003599]", "Immunoglobulin-like domain [IPR007110]", "Importin-alpha, importin-beta-binding domain [IPR002652]", "Importin-beta, N-terminal domain [IPR001494]", "Initiation factor eIF-4 gamma, MA3 [IPR003891]", "Integrator complex subunit 14, C-terminal [IPR045814]", "Integrator complex subunit 3, N-terminal [IPR019333]", "Integrin beta N-terminal [IPR033760]", "Integrin beta subunit, VWA domain [IPR002369]", "Integrin beta subunit, cytoplasmic domain [IPR014836]", "Integrin beta subunit, tail [IPR012896]", "Integrin beta, epidermal growth factor-like domain 1 [IPR040622]", "Integrin-linked protein kinase, pseudokinase domain [IPR035692]", "Intermediate filament head, DNA-binding domain [IPR006821]", "Intermediate filament, rod domain [IPR039008]", "Intracellular hyaluronan-binding protein 4, N-terminal domain [IPR032381]", "Intron-binding protein aquarius, N-terminal [IPR032174]", "Ion transporter-like, CBS domain [IPR044751]", "Iron sulphur domain-containing, mitoNEET, N-terminal [IPR019610]", "Iron-binding zinc finger, CDGSH type [IPR018967]", "Isochorismatase-like [IPR000868]", "Isoleucyl tRNA synthetase type 1, anticodon-binding domain [IPR033708]", "Isoleucyl tRNA synthetase type 2, anticodon-binding domain [IPR033709]", "Isopenicillin N synthase-like, Fe(2+) 2OG dioxygenase domain [IPR044861]", "Isopropylmalate dehydrogenase-like domain [IPR024084]", "JAB1/MPN/MOV34 metalloenzyme domain [IPR000555]", "JNK-interacting protein, leucine zipper II [IPR032486]", "JNK/Rab-associated protein-1, N-terminal [IPR019143]", "JmjC domain [IPR003347]", "Jumonji, helical domain [IPR041070]", "K Homology domain [IPR004087]", "K Homology domain, type 1 [IPR004088]", "K Homology domain, type 2 [IPR004044]", "KASH domain [IPR012315]", "KHDRBS, Qua1 domain [IPR032571]", "KOW [IPR005824]", "Kindlin-2, N-terminal [IPR040790]", "Kindlin/fermitin, PH domain [IPR037837]", "Kinesin motor domain [IPR001752]", "Kinesin-associated microtubule-binding domain [IPR025901]", "Kinesin-like [IPR022164]", "Kinesin-like protein Kif23, Arf6-interacting domain [IPR032384]", "Kri1-like, C-terminal [IPR024626]", "Ku, C-terminal [IPR014893]", "Ku70/Ku80 C-terminal arm [IPR005160]", "Ku70/Ku80 beta-barrel domain [IPR006164]", "Ku70/Ku80, N-terminal alpha/beta [IPR005161]", "L1 transposable element, RRM domain [IPR043636]", "L1 transposable element, dsRBD-like domain [IPR035300]", "L1 transposable element, trimerization domain [IPR035301]", "L27 domain [IPR004172]", "L27 domain, C-terminal [IPR014775]", "LAIKA domain [IPR045353]", "LARP4, RNA recognition motif [IPR034903]", "LARP5, RNA recognition motif [IPR034900]", "LARP7, RNA recognition motif 1 [IPR034887]", "LARP7, RNA recognition motif 2 [IPR034910]", "LEM domain [IPR003887]", "LEM-like domain [IPR013146]", "LETM1, ribosome-binding domain [IPR033122]", "LETM1-like [IPR011685]", "LIS1 homology motif [IPR006594]", "LSM domain, eukaryotic/archaea-type [IPR001163]", "LSM-interacting domain [IPR008669]", "LYRM2, LYR domain [IPR045293]", "La protein, xRRM domain [IPR014886]", "La-related protein 7, La domain [IPR034946]", "La-type HTH domain [IPR006630]", "Lactate/malate dehydrogenase, C-terminal [IPR022383]", "Lactate/malate dehydrogenase, N-terminal [IPR001236]", "Lamin tail domain [IPR001322]", "Lamin-B receptor of TUDOR domain [IPR019023]", "Lamina-associated polypeptide 2 alpha, C-terminal [IPR021623]", "Laminin G domain [IPR001791]", "Large proline-rich protein BAG6 [IPR021925]", "Lasp1, SH3 domain [IPR035630]", "Legume-like lectin [IPR005052]", "Lens epithelium-derived growth factor, integrase-binding domain [IPR021567]", "Lethal giant larvae homologue 2 [IPR013577]", "Leucine zipper, homeobox-associated [IPR003106]", "Leucine-rich repeat N-terminal domain [IPR000372]", "Leukocyte surface antigen CD47, IgV [IPR037805]", "Linker histone H1/H5, domain H15 [IPR005818]", "Lipocalin/cytosolic fatty-acid binding domain [IPR000566]", "Liprin-alpha, SAM domain repeat 1 [IPR037620]", "Liprin-alpha, SAM domain repeat 2 [IPR037621]", "Liprin-alpha, SAM domain repeat 3 [IPR037622]", "Lon, substrate-binding domain [IPR003111]", "Longin domain [IPR010908]", "Lsm14-like, N-terminal [IPR025609]", "Lsm16, N-terminal [IPR034107]", "LsmAD domain [IPR009604]", "Lunapark domain [IPR019273]", "Lysine-tRNA ligase, class II, N-terminal [IPR044136]", "Lysophosphatidylcholine acyltransferase LPCAT1-like [IPR045252]", "Lysyl-tRNA synthetase, class II, C-terminal [IPR018149]", "M60-like domain, N-terminal [IPR035423]", "MAGE homology domain [IPR002190]", "MAN1, RNA recognition motif [IPR034394]", "MANSC domain [IPR013980]", "MATH/TRAF domain [IPR002083]", "MCM N-terminal domain [IPR027925]", "MCM OB domain [IPR033762]", "MCM domain [IPR001208]", "MCM, AAA-lid domain [IPR041562]", "MD-2-related lipid-recognition domain [IPR003172]", "MDM2-binding protein, N-terminal domain [IPR029421]", "MDM2-binding protein, central domain [IPR029420]", "MDN2-binding protein, C-terminal domain [IPR029418]", "MEF-2, RNA recognition motif 1 [IPR034630]", "MEF-2, RNA recognition motif 3 [IPR034631]", "MENTAL domain [IPR019498]", "MHC class I alpha chain, alpha1 alpha2 domains [IPR001039]", "MHC class I, alpha chain, C-terminal [IPR010579]", "MHC class I-like antigen recognition-like [IPR011161]", "MIA2, SH3 domain [IPR035555]", "MIF4G-like, type 1 [IPR015172]", "MIF4G-like, type 2 [IPR015174]", "MIF4G-like, type 3 [IPR003890]", "MIRO domain [IPR020860]", "MIT domain [IPR007330]", "MKI67 FHA domain-interacting nucleolar phosphoprotein, FHA Ki67 binding [IPR021043]", "MMS19, C-terminal [IPR024687]", "MMS19, N-terminal [IPR029240]", "MOSC, N-terminal beta barrel [IPR005303]", "MPN domain [IPR037518]", "MPP1, SH3 domain [IPR035475]", "MPP2, SH3 domain [IPR035602]", "MPP6, SH3 domain [IPR035603]", "MRG domain [IPR026541]", "MRH domain [IPR044865]", "MRPL44, double-stranded RNA binding domain [IPR044444]", "MYND-like zinc finger [IPR031615]", "MYST, zinc finger domain [IPR040706]", "Macro domain [IPR002589]", "Mad3/Bub1 homology region 1 [IPR013212]", "Major facilitator superfamily domain [IPR020846]", "Major sperm protein (MSP) domain [IPR000535]", "Malectin domain [IPR021720]", "Malic enzyme, N-terminal domain [IPR012301]", "Malic enzyme, NAD-binding [IPR012302]", "Man1/Src1, C-terminal [IPR018996]", "Manganese/iron superoxide dismutase, C-terminal [IPR019832]", "Manganese/iron superoxide dismutase, N-terminal [IPR019831]", "Mannose-1-phosphate guanyltransferase, N-terminal domain [IPR045233]", "MaoC-like dehydratase domain [IPR002539]", "Marvel domain [IPR008253]", "Matrin-3, RNA recognition motif 1 [IPR034928]", "Matrin-3, RNA recognition motif 2 [IPR034930]", "Matrin/U1-C, C2H2-type zinc finger [IPR000690]", "Matrin/U1-C-like, C2H2-type zinc finger [IPR003604]", "Mcm6, C-terminal winged-helix domain [IPR041024]", "Mediator complex, subunit Med1 [IPR019680]", "Membrane insertase YidC/Oxa1, C-terminal [IPR028055]", "Metallo-beta-lactamase [IPR001279]", "Metastasis-associated protein MTA1, R1 domain [IPR035170]", "Metaxin, glutathione S-transferase domain [IPR033468]", "Methionine synthase, B12-binding domain [IPR033706]", "Methionine--tRNA ligase, N-terminal [IPR041598]", "Methioninyl-tRNA synthetase core domain [IPR033911]", "Methionyl-tRNA synthetase, anticodon-binding domain [IPR041872]", "Methionyl/Leucyl tRNA synthetase [IPR015413]", "Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding [IPR013155]", "Methyl-CpG DNA binding [IPR001739]", "Methylglyoxal synthase-like domain [IPR011607]", "Methylmalonyl-CoA mutase, C-terminal [IPR006159]", "Methylmalonyl-CoA mutase, alpha chain, catalytic [IPR006098]", "Methylmalonyl-CoA mutase, alpha/beta chain, catalytic [IPR006099]", "Methyltransferase domain 25 [IPR041698]", "Methyltransferase type 11 [IPR013216]", "Methyltransferase type 12 [IPR013217]", "Mib-herc2 [IPR010606]", "Micro-fibrillar-associated protein 1, C-terminal [IPR009730]", "Midasin AAA lid domain 5 [IPR041190]", "Midasin, AAA lid domain 7 [IPR040848]", "Midline-1, COS domain [IPR040859]", "Minichromosome loss protein Mcl1, middle region [IPR022100]", "Misato Segment II tubulin-like domain [IPR019605]", "Mitochondria fission protein Fis1, cytosolic domain [IPR033745]", "Mitochondrial apoptosis-inducing factor, C-terminal domain [IPR029324]", "Mitochondrial cytochrome c oxidase subunit VIc/VIIs [IPR034884]", "Mitochondrial degradasome RNA helicase subunit, C-terminal domain [IPR022192]", "Mitochondrial outer membrane transport complex Sam37/metaxin, N-terminal domain [IPR019564]", "MnmE, helical domain [IPR025867]", "MoaB/Mog domain [IPR001453]", "MoeA, C-terminal, domain IV [IPR005111]", "MoeA, N-terminal and linker domain [IPR005110]", "Molybdenum cofactor sulfurase, C-terminal [IPR005302]", "Molybdopterin oxidoreductase [IPR006656]", "Molybdopterin oxidoreductase, 4Fe-4S domain [IPR006963]", "Mon2, C-terminal [IPR032817]", "Mon2, dimerisation and cyclophilin-binding domain [IPR032629]", "Mot1, ATP-binding domain [IPR044078]", "Mot1, central domain [IPR022707]", "Mre11 nuclease, N-terminal metallophosphatase domain [IPR041796]", "Mre11, DNA-binding [IPR007281]", "Mst1 SARAH domain [IPR024205]", "Mu homology domain [IPR028565]", "Mu2, C-terminal domain [IPR043512]", "Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal [IPR031717]", "Multiple myeloma tumor-associated protein 2-like, N-terminal [IPR019315]", "Multiprotein bridging factor 1, N-terminal [IPR013729]", "Myb domain [IPR017930]", "Myo-inositol-1-phosphate synthase, GAPDH-like [IPR013021]", "Myosin VI, cargo binding domain [IPR032412]", "Myosin head, motor domain [IPR001609]", "Myosin phosphatase-RhoA interacting protein, PH domain [IPR039597]", "Myosin tail [IPR002928]", "Myosin, N-terminal, SH3-like [IPR004009]", "Myristoyl-CoA:protein N-myristoyltransferase, C-terminal [IPR022677]", "Myristoyl-CoA:protein N-myristoyltransferase, N-terminal [IPR022676]", "N-acetylgalactosaminyltransferase [IPR045885]", "N-acetylneuraminic acid synthase, N-terminal [IPR013132]", "N-end aminoacyl transferase, N-terminal [IPR007471]", "N-end rule aminoacyl transferase, C-terminal [IPR007472]", "N-terminal extension of GAT domain [IPR041198]", "NAD(P) binding domain of glutamate dehydrogenase [IPR033922]", "NAD(P) transhydrogenase, alpha subunit, C-terminal [IPR024605]", "NAD(P)-binding domain [IPR016040]", "NAD-dependent epimerase/dehydratase [IPR001509]", "NAD/GMP synthase [IPR022310]", "NADH-quinone oxidoreductase, chain G, C-terminal [IPR015405]", "NADH-quinone oxidoreductase, subunit D [IPR001135]", "NADH-ubiquinone oxidoreductase 51kDa subunit, FMN-binding domain [IPR011538]", "NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain [IPR019575]", "NADH:ubiquinone oxidoreductase, 30kDa subunit [IPR001268]", "NADH:ubiquinone oxidoreductase, subunit G, iron-sulphur binding [IPR019574]", "NADH:ubiquinone oxidoreductase-like, 20kDa subunit [IPR006137]", "NADP transhydrogenase beta-like domain [IPR034300]", "NADP-dependent oxidoreductase domain [IPR023210]", "NCBP2, RNA recognition motif [IPR034148]", "NDUFB9, LYR domain [IPR045292]", "NECAP, PHear domain [IPR012466]", "NEDD8 ultimate buster 1, ubiquitin-like domain [IPR041207]", "NET domain [IPR027353]", "NF-kappaB-repression factor, R3H domain [IPR034071]", "NFACT protein, C-terminal [IPR021846]", "NFACT, RNA-binding domain [IPR008532]", "NFkappaB IPT domain [IPR033926]", "NGN domain [IPR005100]", "NGN domain, eukaryotic [IPR039385]", "NHL2, NHL repeat domain [IPR045302]", "NIPSNAP [IPR012577]", "NLE [IPR012972]", "NOG, C-terminal [IPR012973]", "NOG1, N-terminal helical domain [IPR041623]", "NOP5, N-terminal [IPR012974]", "NOPS [IPR012975]", "NOSIC [IPR012976]", "NP60, PWWP domain [IPR035501]", "NPL4, zinc-binding putative [IPR007716]", "NSD, Cys-His rich domain [IPR041306]", "NUC153 [IPR012580]", "NUC205 domain [IPR012584]", "NUDIX hydrolase [IPR020476]", "NUDIX hydrolase domain [IPR000086]", "NVL2, nucleolin binding domain [IPR031996]", "Nascent polypeptide-associated complex NAC domain [IPR002715]", "Negative elongation factor E, RNA recognition motif [IPR034637]", "Neurobeachin-like, DUF1088 [IPR010508]", "Neurobeachin/BDCP, DUF4704 [IPR031570]", "Nibrin, second BRCT domain [IPR032429]", "Nicastrin, small lobe [IPR041084]", "Nicotinamide phosphoribosyltransferase, N-terminal domain [IPR041529]", "Nicotinate/nicotinamide phosphoribosyltransferase [IPR041525]", "Niemann-Pick C1, N-terminal [IPR032190]", "Nischarin, PX domain [IPR037904]", "Nitric oxide synthase-interacting protein, zinc-finger [IPR031790]", "Nmd3, N-terminal [IPR007064]", "Non-canonical purine NTP phosphatase/PRRC1 [IPR026533]", "Nop domain [IPR002687]", "Nop2p [IPR011023]", "Nrap protein domain 1 [IPR035082]", "Nrap protein, domain 2 [IPR035367]", "Nrap protein, domain 3 [IPR035368]", "Nrap protein, domain 4 [IPR035369]", "Nrap protein, domain 5 [IPR035370]", "Nrap protein, domain 6 [IPR035371]", "Nuclear RNA export factor Tap, RNA-binding domain [IPR015245]", "Nuclear condensin complex subunit 3, C-terminal domain [IPR025977]", "Nuclear migration protein nudC [IPR032572]", "Nuclear pore complex protein Nup214, phenylalanine-glycine (FG) domain [IPR041553]", "Nuclear pore complex, NUP2/50/61 [IPR015007]", "Nuclear pore localisation protein NPL4, C-terminal [IPR007717]", "Nuclear pore localisation protein Npl4, ubiquitin-like domain [IPR024682]", "Nuclear protein 96 [IPR021967]", "Nuclear transport factor 2 domain [IPR002075]", "Nuclear transport factor 2, eukaryote [IPR018222]", "Nuclear-interacting partner of ALK/Rsm1-like [IPR013909]", "Nucleolar GTP-binding protein 1, Rossman-fold domain [IPR010674]", "Nucleolar GTP-binding protein 2, N-terminal domain [IPR012971]", "Nucleolar complex-associated protein 3, N-terminal [IPR011501]", "Nucleolar pre-ribosomal-associated protein 1, C-terminal domain [IPR032436]", "Nucleolar pre-ribosomal-associated protein 1, N-terminal [IPR021714]", "Nucleolar protein 7, C-terminal [IPR012579]", "Nucleolar protein 8, RNA recognition motif [IPR034138]", "Nucleolin, RNA recognition motif 1 [IPR034230]", "Nucleolin, RNA recognition motif 2 [IPR034233]", "Nucleolin, RNA recognition motif 3 [IPR034234]", "Nucleolin, RNA recognition motif 4 [IPR034235]", "Nucleophosmin, C-terminal [IPR032569]", "Nucleoplasmin core domain [IPR024057]", "Nucleoporin Nup153, N-terminal [IPR013913]", "Nucleoporin Nup188, N-terminal [IPR018864]", "Nucleoporin Nup54, alpha-helical domain [IPR025712]", "Nucleoporin, NSP1-like, C-terminal [IPR007758]", "Nucleoporin, Nup133/Nup155-like, C-terminal [IPR007187]", "Nucleoporin, Nup133/Nup155-like, N-terminal [IPR014908]", "Nucleoprotein TPR/MLP1 [IPR012929]", "Nucleoredoxin, redox inactive TRX-like domain b' [IPR041861]", "Nucleoside diphosphate kinase-like domain [IPR034907]", "Nucleoside phosphorylase domain [IPR000845]", "Nucleotide exchange factor Fes1 [IPR013918]", "Nucleotidyl transferase domain [IPR005835]", "NudC N-terminal domain [IPR025934]", "NudC domain-containing protein 2, p23 domain [IPR037902]", "NuoE domain [IPR042128]", "Nup358/RanBP2 E3 ligase domain [IPR022011]", "Nup54, C-terminal interacting domain [IPR040985]", "NusG, N-terminal [IPR006645]", "O-GlcNAc transferase, C-terminal [IPR029489]", "OB-fold nucleic acid binding domain, AA-tRNA synthetase-type [IPR004365]", "OBG-type guanine nucleotide-binding (G) domain [IPR031167]", "OCRE domain [IPR041591]", "OTU domain [IPR003323]", "Occludin homology domain [IPR010844]", "Olduvai domain [IPR010630]", "Orotate phosphoribosyl transferase domain [IPR004467]", "Orotidine 5'-phosphate decarboxylase domain [IPR001754]", "Ovarian carcinoma immunoreactive antigen domain [IPR009764]", "Oxidoreductase FAD/NAD(P)-binding [IPR001433]", "Oxidoreductase, N-terminal domain [IPR041694]", "Oxoglutarate/iron-dependent dioxygenase [IPR005123]", "P-type ATPase, haloacid dehalogenase domain [IPR044492]", "P-type trefoil domain [IPR000519]", "PA domain [IPR003137]", "PABP, RNA recognition motif 2 [IPR045305]", "PACSIN1/PACSIN2, SH3 domain [IPR035743]", "PACSIN2, F-BAR domain [IPR037453]", "PADR1 domain [IPR012982]", "PAP/25A-associated [IPR002058]", "PARN, R3H domain [IPR034042]", "PAS domain [IPR000014]", "PAZ domain [IPR003100]", "PB1 domain [IPR000270]", "PCNA-associated factor, histone-like domain [IPR031444]", "PD-(D/E)XK endonuclease-like domain, AddAB-type [IPR038726]", "PDIP3, RNA recognition motif [IPR034784]", "PDZ domain [IPR001478]", "PH-BEACH domain [IPR023362]", "PI31 proteasome regulator, N-terminal [IPR021625]", "PI31 proteasome regulator, C-terminal [IPR013886]", "PIH1, N-terminal [IPR012981]", "PIH1D1/2/3, CS-like domain [IPR041442]", "PIK-related kinase [IPR014009]", "PIK-related kinase, FAT [IPR003151]", "PIN domain [IPR002716]", "PITH domain [IPR010400]", "PKD domain [IPR000601]", "PKD/Chitinase domain [IPR022409]", "PLAA family ubiquitin binding domain [IPR015155]", "PLC-gamma, C-terminal SH2 domain [IPR035023]", "PLC-gamma, N-terminal SH2 domain [IPR035024]", "PLD-like domain [IPR032803]", "POLO box domain [IPR000959]", "POPLD domain [IPR012590]", "POTRA domain [IPR034746]", "PP5, C-terminal metallophosphatase domain [IPR041753]", "PPIL4-like, cyclophilin domain [IPR035538]", "PPM-type phosphatase domain [IPR001932]", "PPP domain [IPR013235]", "PRKRA, first double-stranded RNA binding domain [IPR044465]", "PRKRA, second double-stranded RNA binding domain [IPR044466]", "PRKRA, third double-stranded RNA binding domain [IPR044467]", "PRMT5 arginine-N-methyltransferase [IPR035075]", "PRMT5, TIM barrel domain [IPR035247]", "PRMT5, oligomerisation domain [IPR035248]", "PRO8NT domain [IPR012591]", "PROCN domain [IPR012592]", "PROCT domain [IPR012984]", "PRP1 splicing factor, N-terminal [IPR010491]", "PRP8 domain IV core [IPR021983]", "PSF, NOPS domain [IPR034526]", "PSF, RNA recognition motif 1 [IPR034525]", "PSI domain [IPR016201]", "PSP, proline-rich [IPR006568]", "PSP1, RNA recognition motif 1 [IPR034522]", "PSP1, RNA recognition motif 2 [IPR034523]", "PTB/PI domain [IPR006020]", "PTBP1, RNA recognition motif 1 [IPR035000]", "PTBP1, RNA recognition motif 2-like [IPR021790]", "PTBP1, RNA recognition motif 3 [IPR035001]", "PTBP2, RNA recognition motif 1 [IPR035002]", "PTBP2, RNA recognition motif 3 [IPR034799]", "PTBP2, RNA recognition motif 4 [IPR034800]", "PUA domain [IPR002478]", "PUF60, RNA recognition motif 1 [IPR034209]", "PUF60, RNA recognition motif 2 [IPR034211]", "PUF60, RNA recognition motif 3 [IPR034212]", "PUL domain [IPR013535]", "PWI domain [IPR002483]", "PWWP domain [IPR000313]", "Paf1 complex subunit Cdc73, N-terminal domain [IPR032041]", "Palladin, C-terminal immunoglobulin-like domain [IPR033017]", "Pancreatic trypsin inhibitor Kunitz domain [IPR002223]", "Patatin-like phospholipase domain [IPR002641]", "Patatin-like phospholipase domain containing protein 8-like [IPR045217]", "Pentacotripeptide-repeat region of PRORP [IPR033443]", "Pep3/Vps18/deep orange [IPR007810]", "Peptidase C12, C-terminal domain [IPR041507]", "Peptidase C12, ubiquitin carboxyl-terminal hydrolase [IPR001578]", "Peptidase C14, p20 domain [IPR001309]", "Peptidase C14, caspase non-catalytic subunit p10 [IPR002138]", "Peptidase C14A, caspase catalytic domain [IPR015917]", "Peptidase C19, ubiquitin carboxyl-terminal hydrolase [IPR001394]", "Peptidase C19, ubiquitin-specific peptidase, DUSP domain [IPR006615]", "Peptidase C1A, papain C-terminal [IPR000668]", "Peptidase C2, calpain, catalytic domain [IPR001300]", "Peptidase C2, calpain, domain III [IPR022683]", "Peptidase C2, calpain, large subunit, domain III [IPR022682]", "Peptidase M1, leukotriene A4 hydrolase/aminopeptidase C-terminal [IPR015211]", "Peptidase M1, membrane alanine aminopeptidase [IPR014782]", "Peptidase M13, C-terminal domain [IPR018497]", "Peptidase M13, N-terminal domain [IPR008753]", "Peptidase M14, carboxypeptidase A [IPR000834]", "Peptidase M16, C-terminal [IPR007863]", "Peptidase M16, N-terminal [IPR011765]", "Peptidase M16, middle/third domain [IPR032632]", "Peptidase M16C associated [IPR013578]", "Peptidase M17, leucyl aminopeptidase, C-terminal [IPR000819]", "Peptidase M17, leucyl aminopeptidase, N-terminal [IPR008283]", "Peptidase M20, dimerisation domain [IPR011650]", "Peptidase M24 [IPR000994]", "Peptidase M24, C-terminal domain [IPR032416]", "Peptidase M28 [IPR007484]", "Peptidase M3A/M3B catalytic domain [IPR001567]", "Peptidase M41 [IPR000642]", "Peptidase M41, FtsH extracellular [IPR011546]", "Peptidase M48 [IPR001915]", "Peptidase S16, Lon proteolytic domain [IPR008269]", "Peptidase S24/S26A/S26B/S26C [IPR015927]", "Peptidase S26 [IPR019533]", "Peptidase S53, activation domain [IPR015366]", "Peptidase S59, nucleoporin [IPR007230]", "Peptidase S8/S53 domain [IPR000209]", "Peptidase S8A, tripeptidyl peptidase II [IPR022229]", "Peptidase S9, prolyl oligopeptidase, catalytic domain [IPR001375]", "Peptidase S9A, N-terminal domain [IPR023302]", "Peptidase family M60 domain [IPR031161]", "Peptide chain release factor class I [IPR000352]", "Peptidyl-prolyl cis-trans isomerase E, RNA recognition motif [IPR034168]", "Peptidyl-prolyl cis-trans isomerase, PpiC-type [IPR000297]", "Pericentriolar material 1 protein, C-terminal [IPR031446]", "Peripheral subunit-binding domain [IPR004167]", "Peroxiredoxin, C-terminal [IPR019479]", "Peroxisome membrane anchor protein Pex14p, N-terminal [IPR006785]", "PheRS DNA binding domain 2 [IPR040586]", "PheRS, DNA binding domain 1 [IPR040724]", "PheRS, DNA binding domain 3 [IPR040725]", "Phenylacetic acid degradation-related domain [IPR003736]", "Phenylalanine--tRNA ligase beta subunit, B1 domain [IPR040659]", "Phenylalanyl tRNA synthetase beta chain, core domain [IPR041616]", "Phenylalanyl-tRNA synthetase [IPR002319]", "Phosducin, thioredoxin-like domain [IPR024253]", "Phosphatidic acid phosphatase type 2/haloperoxidase [IPR000326]", "Phosphatidylinositol 3-/4-kinase, catalytic domain [IPR000403]", "Phosphatidylinositol-4-phosphate 5-kinase, core [IPR002498]", "Phosphatidylinositol-specific phospholipase C, X domain [IPR000909]", "Phosphoadenosine phosphosulphate reductase [IPR002500]", "Phosphoenolpyruvate carboxykinase, C-terminal P-loop domain [IPR035077]", "Phosphoenolpyruvate carboxykinase, GTP-utilising, N-terminal [IPR035078]", "Phosphofructokinase domain [IPR000023]", "Phosphoglucose isomerase, SIS domain 1 [IPR035476]", "Phosphoglucose isomerase, SIS domain 2 [IPR035482]", "Phosphoinositide 3-kinase, accessory (PIK) domain [IPR001263]", "Phospholipase C, phosphatidylinositol-specific, Y domain [IPR001711]", "Phospholipase D-like domain [IPR025202]", "Phospholipase D/Transphosphatidylase [IPR001736]", "Phospholipase/carboxylesterase/thioesterase [IPR003140]", "Phospholipid/glycerol acyltransferase [IPR002123]", "Phosphopantetheine binding ACP domain [IPR009081]", "Phosphoribosylformylglycinamidine synthase, N-terminal [IPR040707]", "Phosphoribosylformylglycinamidine synthase, linker domain [IPR041609]", "Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain [IPR020561]", "Phosphoribosylglycinamide synthetase, C-domain [IPR020560]", "Phosphoribosylglycinamide synthetase, N-terminal [IPR020562]", "Phosphoribosyltransferase domain [IPR000836]", "Phosphotyrosine protein phosphatase I [IPR023485]", "Phox homology [IPR001683]", "Pinin/SDK [IPR006787]", "Pinin/SDK/MemA protein [IPR006786]", "Pirin, C-terminal domain [IPR008778]", "Pirin, N-terminal domain [IPR003829]", "Plasma membrane calcium transporting P-type ATPase, C-terminal [IPR022141]", "Pleckstrin homology domain 8 [IPR041680]", "Pleckstrin homology domain 9 [IPR041681]", "Pleckstrin homology domain [IPR001849]", "Pleckstrin homology domain, spectrin-type [IPR001605]", "Plectin/S10, N-terminal [IPR005326]", "Polo-like kinase 1, catalytic domain [IPR033702]", "Poly(A)-specific ribonuclease, RNA-binding [IPR014789]", "Poly(ADP-ribose) polymerase, catalytic domain [IPR012317]", "Poly(ADP-ribose) polymerase, regulatory domain [IPR004102]", "Polyadenylate-binding protein/Hyperplastic disc protein [IPR002004]", "Polyamine biosynthesis domain [IPR030374]", "Polycomb group protein, RNA binding region [IPR033763]", "Polycomb protein, VEFS-Box [IPR019135]", "Polyketide synthase, C-terminal extension [IPR032821]", "Polyketide synthase, beta-ketoacyl synthase domain [IPR020841]", "Polyketide synthase, dehydratase domain [IPR020807]", "Polyketide synthase, enoylreductase domain [IPR020843]", "Polyketide synthase, ketoreductase domain [IPR013968]", "Polyketide synthase, phosphopantetheine-binding domain [IPR020806]", "Polypyrimidine tract-binding protein1/2/3, RNA recognition motif 2 [IPR034798]", "Polyribonucleotide 5'-hydroxyl-kinase Clp1, P-loop domain [IPR032319]", "Polyribonucleotide nucleotidyltransferase, RNA-binding domain [IPR015848]", "Polysaccharide biosynthesis domain [IPR021148]", "Pop1, N-terminal [IPR009723]", "Porphobilinogen deaminase, C-terminal [IPR022418]", "Porphobilinogen deaminase, N-terminal [IPR022417]", "Possible tRNA binding domain [IPR027992]", "Post-SET domain [IPR003616]", "Potassium channel tetramerisation-type BTB domain [IPR003131]", "Potentiating neddylation domain [IPR005176]", "Pre-PUA domain [IPR041366]", "Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term [IPR021718]", "Pre-mRNA polyadenylation factor Fip1 domain [IPR007854]", "Pre-mRNA processing factor 4 (PRP4)-like [IPR014906]", "Pre-mRNA splicing factor component Cdc5p/Cef1, C-terminal [IPR021786]", "Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding [IPR019581]", "Pre-mRNA-processing-splicing factor 8, U6-snRNA-binding [IPR019580]", "Pre-mRNA-splicing factor 19 [IPR013915]", "Pre-mRNA-splicing factor 3 [IPR013881]", "Pre-rRNA-processing protein Ipi1, N-terminal [IPR024679]", "Pre-rRNA-processing protein RIX1, N-terminal [IPR012583]", "Predicted HAD-superfamily phosphatase, subfamily IA/Epoxide hydrolase, N-terminal [IPR011945]", "Prenylcysteine lyase [IPR010795]", "Probable RNA-binding protein 19, RNA recognition motif 1 [IPR034418]", "Probable RNA-binding protein 19, RNA recognition motif 2 [IPR034417]", "Probable RNA-binding protein 19, RNA recognition motif 3 [IPR034419]", "Probable RNA-binding protein 19, RNA recognition motif 4 [IPR034420]", "Probable RNA-binding protein 19, RNA recognition motif 5 [IPR034423]", "Probable RNA-binding protein 19, RNA recognition motif 6 [IPR034421]", "Proliferating cell nuclear antigen, PCNA, C-terminal [IPR022649]", "Proliferating cell nuclear antigen, PCNA, N-terminal [IPR022648]", "Proline-tRNA ligase, class II, C-terminal [IPR016061]", "Prolyl 4-hydroxylase alpha subunit, Fe(2+) 2OG dioxygenase domain [IPR044862]", "Prolyl 4-hydroxylase alpha-subunit, N-terminal [IPR013547]", "Prolyl 4-hydroxylase, alpha subunit [IPR006620]", "Prolyl-tRNA synthetase, catalytic domain [IPR033721]", "Propionyl-coenzyme A carboxylase, BT domain [IPR041265]", "Prostaglandin E synthase 2, C-terminal [IPR034335]", "Proteasomal ATPase OB C-terminal domain [IPR032501]", "Proteasome activator Blm10, mid region [IPR032430]", "Proteasome activator PA28, C-terminal domain [IPR003186]", "Proteasome activator PA28, N-terminal domain [IPR003185]", "Proteasome activator complex subunit 4 C-terminal domain [IPR021843]", "Proteasome alpha-subunit, N-terminal domain [IPR000426]", "Proteasome beta subunit, C-terminal [IPR024689]", "Proteasome component (PCI) domain [IPR000717]", "Protein HGH1 C-terminal [IPR007206]", "Protein HGH1 N-terminal [IPR007205]", "Protein Kinase B beta, catalytic domain [IPR034677]", "Protein Kinase B, pleckstrin homology domain [IPR039026]", "Protein O-mannosyl-transferase TMTC, DUF1736 [IPR013618]", "Protein RED, C-terminal [IPR012492]", "Protein disulfide-isomerase A3, first redox inactive TRX-like domain b [IPR041868]", "Protein disulfide-isomerase A4, TRX-like domain b [IPR041866]", "Protein furry, C-terminal [IPR045842]", "Protein kinase C-like, phorbol ester/diacylglycerol-binding domain [IPR002219]", "Protein kinase domain [IPR000719]", "Protein kinase, C-terminal [IPR017892]", "Protein of unknown function DUF3504 [IPR021893]", "Protein of unknown function DUF3715 [IPR022188]", "Protein phosphatase 1 binding domain [IPR029334]", "Protein polybromo-1, Bromodomain 5 [IPR037968]", "Protein quaking, putative nuclear localisation signal [IPR032367]", "Protein-tyrosine phosphatase, catalytic [IPR003595]", "Prp31 C-terminal [IPR019175]", "Pseudouridine synthase II, N-terminal [IPR002501]", "Pseudouridine synthase, TruD, insertion domain [IPR011760]", "Pterin-binding domain [IPR000489]", "Pumilio homology domain [IPR033133]", "Pumilio, RNA binding domain [IPR033712]", "PurE domain [IPR000031]", "PurM-like, C-terminal domain [IPR010918]", "PurM-like, N-terminal domain [IPR016188]", "Putative 5-3 exonuclease [IPR004859]", "Putative RNA methylase domain [IPR000241]", "Putative RNA-binding protein 27, RNA recognition motif [IPR034451]", "Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain [IPR004099]", "Pyridoxamine kinase/Phosphomethylpyrimidine kinase [IPR013749]", "Pyrroline-5-carboxylate reductase, catalytic, N-terminal [IPR028939]", "Pyrroline-5-carboxylate reductase, dimerisation domain [IPR029036]", "Pyruvate carboxyltransferase [IPR000891]", "Pyruvate kinase, C-terminal [IPR015795]", "Pyruvate kinase, barrel [IPR015793]", "R3H domain [IPR001374]", "RABX5, catalytic core helical domain [IPR041545]", "RAD23A/RAD23B, UBA1 domain [IPR041811]", "RAD50, zinc hook [IPR013134]", "RAP domain [IPR013584]", "RBM10, OCRE domain [IPR035618]", "RBM12, RNA recognition motif 1 [IPR034591]", "RBM12, RNA recognition motif 2 [IPR034594]", "RBM12, RNA recognition motif 3 [IPR034855]", "RBM12, RNA recognition motif 4 [IPR034856]", "RBM12, RNA recognition motif 5 [IPR034854]", "RBM12B, RNA recognition motif 2 [IPR034588]", "RBM12B, RNA recognition motif 3 [IPR034858]", "RBM14, RNA recognition motif 1 [IPR034506]", "RBM14, RNA recognition motif 2 [IPR034507]", "RBM1CTR [IPR012604]", "RBM25, RNA recognition motif [IPR034268]", "RBM26, RNA recognition motif 1 [IPR034859]", "RBM26-like, RNA recognition motif 2 [IPR039511]", "RBM3/CIRBP, RNA recognition motif [IPR034278]", "RBM34, RNA recognition motif 1 [IPR034220]", "RBM34, RNA recognition motif 2 [IPR034221]", "RBM4, RNA recognition motif 1 [IPR034897]", "RBM4, RNA recognition motif 2 [IPR034898]", "RBM42, RNA recognition motif [IPR034215]", "RBM8, RNA recognition motif [IPR033744]", "RDD [IPR010432]", "RED-like, N-terminal [IPR012916]", "REKLES domain [IPR023334]", "RFX1 transcription activation region [IPR007668]", "RH1 domain [IPR034743]", "RH2 domain [IPR034744]", "RHIM domain [IPR025735]", "RII binding domain [IPR018459]", "RING finger protein 219, RING finger [IPR035691]", "RING-type zinc-finger, LisH dimerisation motif [IPR027370]", "RIP1, Death domain [IPR037934]", "RL domain [IPR041252]", "RLI, domain 1 [IPR034348]", "RNA 3'-terminal phosphate cyclase domain [IPR023797]", "RNA 3'-terminal phosphate cyclase, insert domain [IPR013791]", "RNA binding activity-knot of a chromodomain [IPR025995]", "RNA exonuclease 4, DEDDh 3'-5' exonuclease domain [IPR037431]", "RNA helicase UPF1, 1B domain [IPR040812]", "RNA helicase UPF1, Cys/His rich zinc-binding domain [IPR018999]", "RNA helicase, DEAD-box type, Q motif [IPR014014]", "RNA polymerase II-associated protein 1, C-terminal [IPR013929]", "RNA polymerase II-associated protein 1, N-terminal [IPR013930]", "RNA polymerase Rpb1, domain 1 [IPR007080]", "RNA polymerase Rpb1, domain 3 [IPR007066]", "RNA polymerase Rpb1, domain 4 [IPR007083]", "RNA polymerase Rpb1, domain 5 [IPR007081]", "RNA polymerase Rpb1, domain 6 [IPR007075]", "RNA polymerase Rpb1, domain 7 [IPR007073]", "RNA polymerase Rpb2, domain 2 [IPR007642]", "RNA polymerase Rpb2, domain 3 [IPR007645]", "RNA polymerase Rpb2, domain 4 [IPR007646]", "RNA polymerase Rpb2, domain 5 [IPR007647]", "RNA polymerase Rpb2, domain 7 [IPR007641]", "RNA polymerase Rpb7-like , N-terminal [IPR005576]", "RNA polymerase, N-terminal [IPR006592]", "RNA polymerase, Rpb5, N-terminal [IPR005571]", "RNA polymerase, alpha subunit [IPR000722]", "RNA polymerase, beta subunit, protrusion [IPR007644]", "RNA polymerase, subunit H/Rpb5 C-terminal [IPR000783]", "RNA recognition motif domain [IPR000504]", "RNA recognition motif domain, eukaryote [IPR003954]", "RNA recognition motif, spliceosomal PrP8 [IPR019582]", "RNA-binding S4 domain [IPR002942]", "RNA-binding domain, S1 [IPR022967]", "RNA-binding protein 10, RNA recognition motif 2 [IPR034992]", "RNA-binding protein 5, RNA recognition motif 1 [IPR034991]", "RNA-binding protein 5, RNA recognition motif 2 [IPR034993]", "RNA-binding protein Musashi homologue, RNA recognition motif 1 [IPR034130]", "RNA-binding protein Musashi homologue, RNA recognition motif 2 [IPR034126]", "RNA-polymerase II-associated protein 3-like, C-terminal domain [IPR025986]", "RNA-recognition motif (RRM) Nup35-type domain [IPR007846]", "RNPS1, RNA recognition motif [IPR034201]", "RNase L inhibitor RLI-like, possible metal-binding domain [IPR007209]", "ROCK, Rho binding domain [IPR015008]", "ROK, N-terminal [IPR012987]", "RPN1, N-terminal [IPR040892]", "RQC domain [IPR018982]", "RUN domain [IPR004012]", "RWD domain [IPR006575]", "Rab-GTPase-TBC domain [IPR000195]", "Rab3-GAP regulatory subunit, N-terminal [IPR032839]", "Rab3GAP catalytic subunit, C-terminal [IPR045698]", "Rab3GAP catalytic subunit, conserved domain [IPR026147]", "Rab3GAP regulatory subunit, C-terminal [IPR029257]", "Rabaptin coiled-coil domain [IPR018514]", "Rabaptin, GTPase-Rab5 binding domain [IPR015390]", "Rad21/Rec8-like protein, C-terminal, eukaryotic [IPR006909]", "Rad21/Rec8-like protein, N-terminal [IPR006910]", "Rad50, ATP-binding cassette domain [IPR045171]", "Rad50/SbcC-type AAA domain [IPR038729]", "Radical SAM [IPR007197]", "Radical SAM, C-terminal extension [IPR032432]", "Raly, RNA recognition motif [IPR034502]", "Ran binding domain [IPR000156]", "Ran binding protein 9/10, SPRY domain [IPR035782]", "Ran-GTPase activating protein 1, C-terminal [IPR009109]", "Ran-specific GTPase-activating protein 1, Ran-binding domain [IPR045256]", "Rap1 Myb domain [IPR015010]", "Ras GTPase-activating domain [IPR001936]", "Ras guanine-nucleotide exchange factors catalytic domain [IPR001895]", "Ras-associating (RA) domain [IPR000159]", "Ras-like guanine nucleotide exchange factor, N-terminal [IPR000651]", "RasGAP protein, C-terminal [IPR000593]", "RecF/RecN/SMC, N-terminal [IPR003395]", "Redoxin [IPR013740]", "Regulator of G protein signalling-like domain [IPR015212]", "Rel homology dimerisation domain [IPR032397]", "Rel homology domain (RHD), DNA-binding domain [IPR011539]", "Replication factor A, C-terminal [IPR013955]", "Replication factor C, C-terminal [IPR013748]", "Replication factor-A protein 1, N-terminal [IPR007199]", "Replication protein A, C-terminal [IPR014892]", "Replication protein A, OB domain [IPR031657]", "Reticulon [IPR003388]", "Rho GTPase-activating protein domain [IPR000198]", "Rho GTPase-binding/formin homology 3 (GBD/FH3) domain [IPR014768]", "Rho-associated protein kinase 2, HR1 domain [IPR037311]", "Rhodanese-like domain [IPR001763]", "Ribonuclease H1, N-terminal [IPR011320]", "Ribonuclease HII/HIII domain [IPR024567]", "Ribonuclease II/R [IPR001900]", "Ribonuclease III domain [IPR000999]", "Ribonucleoprotein PTB-binding 1, RNA recognition motif 1 [IPR034633]", "Ribonucleotide reductase large subunit, C-terminal [IPR000788]", "Ribonucleotide reductase large subunit, N-terminal [IPR013509]", "Ribonucleotide reductase, class I , alpha subunit [IPR013346]", "Ribose-phosphate pyrophosphokinase, N-terminal domain [IPR029099]", "Ribosomal L28e/Mak16 [IPR029004]", "Ribosomal Protein L6, KOW domain [IPR041997]", "Ribosomal Proteins L2, RNA binding domain [IPR022666]", "Ribosomal RNA methyltransferase FtsJ domain [IPR002877]", "Ribosomal RNA methyltransferase Spb1, domain of unknown function DUF3381 [IPR024576]", "Ribosomal RNA methyltransferase, Spb1, C-terminal [IPR012920]", "Ribosomal RNA small subunit methyltransferase F, N-terminal [IPR031341]", "Ribosomal RNA-processing protein 14/surfeit locus protein 6, C-terminal domain [IPR029190]", "Ribosomal S6 kinase, N-terminal catalytic domain [IPR041906]", "Ribosomal protein 50S-L18Ae/60S-L20/60S-L18A [IPR023573]", "Ribosomal protein L10e/L16 [IPR016180]", "Ribosomal protein L11, C-terminal [IPR020783]", "Ribosomal protein L11, N-terminal [IPR020784]", "Ribosomal protein L14, KOW motif [IPR041985]", "Ribosomal protein L14e domain [IPR002784]", "Ribosomal protein L18e/L15P [IPR021131]", "Ribosomal protein L19, eukaryotic [IPR033935]", "Ribosomal protein L19/L19e [IPR000196]", "Ribosomal protein L2, C-terminal [IPR022669]", "Ribosomal protein L23/L25, N-terminal [IPR005633]", "Ribosomal protein L30, N-terminal [IPR012988]", "Ribosomal protein L30, ferredoxin-like fold domain [IPR016082]", "Ribosomal protein L5 eukaryotic, C-terminal [IPR025607]", "Ribosomal protein L5, C-terminal [IPR031309]", "Ribosomal protein L5, N-terminal [IPR031310]", "Ribosomal protein L6, N-terminal [IPR005568]", "Ribosomal protein L6, alpha-beta domain [IPR020040]", "Ribosomal protein L7, eukaryotic/archaeal [IPR035808]", "Ribosomal protein L7/L12, C-terminal [IPR013823]", "Ribosomal protein L7/L12, oligomerisation [IPR008932]", "Ribosomal protein L7Ae/L30e/S12e/Gadd45 [IPR004038]", "Ribosomal protein L9, N-terminal [IPR020070]", "Ribosomal protein S10 domain [IPR027486]", "Ribosomal protein S13/S15, N-terminal [IPR012606]", "Ribosomal protein S23/S25, mitochondrial [IPR023611]", "Ribosomal protein S24/S35, mitochondrial, conserved domain [IPR019349]", "Ribosomal protein S3, C-terminal [IPR001351]", "Ribosomal protein S4, KOW domain [IPR041982]", "Ribosomal protein S4/S9, N-terminal [IPR001912]", "Ribosomal protein S4e, N-terminal [IPR013843]", "Ribosomal protein S4e, central region [IPR013845]", "Ribosomal protein S5, C-terminal [IPR005324]", "Ribosomal protein S5, N-terminal [IPR013810]", "Ribosomal protein S6 kinase alpha-3, C-terminal catalytic domain [IPR041905]", "Ribosomal protein S7 domain [IPR023798]", "Ribosomal protein/NADH dehydrogenase domain [IPR007741]", "Ribosome biogenesis protein BMS1/TSR1, C-terminal [IPR007034]", "Ribosome biogenesis protein Bms1, N-terminal [IPR037875]", "Ribosome maturation protein Sdo1/SBDS, C-terminal [IPR018978]", "Ribosome maturation protein Sdo1/SBDS, N-terminal [IPR019783]", "Ribosome receptor lysine/proline rich [IPR007794]", "Ribosome-associated complex head domain [IPR032003]", "Ricin B, lectin domain [IPR000772]", "Right handed beta helix domain [IPR039448]", "RmlD-like substrate binding domain [IPR029903]", "Rpn11/EIF3F, C-terminal [IPR024969]", "Rrp40, S1 domain [IPR037319]", "Rrp44-like cold shock domain [IPR033771]", "RuvB-like, AAA-lid domain [IPR041048]", "S-adenosyl-L-homocysteine hydrolase, NAD binding domain [IPR015878]", "S-adenosylmethionine synthetase, C-terminal [IPR022630]", "S-adenosylmethionine synthetase, N-terminal [IPR022628]", "S-adenosylmethionine synthetase, central domain [IPR022629]", "S1 domain [IPR003029]", "S1-like RNA binding domain [IPR025223]", "S100/CaBP-9k-type, calcium binding, subdomain [IPR013787]", "SAB domain [IPR007477]", "SAC domain [IPR002013]", "SAC3/GANP/THP3, conserved domain [IPR005062]", "SAF domain [IPR013974]", "SAICAR synthetase/ADE2, N-terminal [IPR028923]", "SAM domain [IPR041418]", "SAM-dependent methyltransferase RsmB/NOP2-type [IPR001678]", "SANT domain [IPR017884]", "SANT/Myb domain [IPR001005]", "SAP domain [IPR003034]", "SARAH domain [IPR011524]", "SART3, RNA recognition motif 1 [IPR034217]", "SART3, RNA recognition motif 2 [IPR034218]", "SCAF4, RNA recognition motif [IPR034369]", "SCAN domain [IPR003309]", "SCP2 sterol-binding domain [IPR003033]", "SEC23-interacting protein, SAM domain [IPR037603]", "SEP domain [IPR012989]", "SERRATE/Ars2 , C-terminal [IPR007042]", "SERRATE/Ars2, N-terminal [IPR021933]", "SET domain [IPR001214]", "SETD2/Set2, SET domain [IPR044437]", "SF3A2 domain [IPR031781]", "SF3A3 domain [IPR031774]", "SF3B4, RNA recognition motif 1 [IPR034158]", "SF3B4, RNA recognition motif 2 [IPR034159]", "SF3B6, RNA recognition motif [IPR034150]", "SGNH hydrolase-type esterase domain [IPR013830]", "SGS domain [IPR007699]", "SGTA, homodimerisation domain [IPR032374]", "SH2 domain [IPR000980]", "SH3 domain [IPR001452]", "SHARP, RNA recognition motif 1 [IPR034172]", "SHARP, RNA recognition motif 2 [IPR034173]", "SHARP, RNA recognition motif 3 [IPR034174]", "SHARP, RNA recognition motif 4 [IPR034175]", "SIS domain [IPR001347]", "SKI-interacting protein SKIP, SNW domain [IPR004015]", "SKP1 component, POZ domain [IPR016073]", "SKP1 component, dimerisation [IPR016072]", "SLED domain [IPR021987]", "SLIDE domain [IPR015195]", "SLIRP, RNA recognition motif [IPR034152]", "SMARCA1, N-terminal [IPR044755]", "SMARCC, C-terminal [IPR032451]", "SMARCC, N-terminal [IPR032450]", "SMARCC, SWIRM-associated domain [IPR032448]", "SMCs flexible hinge [IPR010935]", "SMYD3, SET domain [IPR044420]", "SMYD4, SET domain [IPR044421]", "SNAP-25 domain [IPR000928]", "SNARE-complex protein Syntaxin-18, N-terminal [IPR019529]", "SNF2, N-terminal [IPR000330]", "SNX17, atypical FERM-like domain [IPR037836]", "SNX2, PX domain [IPR037918]", "SNX27, PX domain [IPR037833]", "SNX27, RA domain [IPR037835]", "SNX27, atypical FERM-like domain [IPR037827]", "SNX5, PX domain [IPR042135]", "SNX6, PX domain [IPR042136]", "SNX9, SH3 domain [IPR035558]", "SPF45, RNA recognition motif [IPR034653]", "SPRY domain [IPR003877]", "SPRY-associated [IPR006574]", "SR140, RNA recognition motif [IPR035009]", "SRA-YDG [IPR003105]", "SRCR domain [IPR001190]", "SRCR-like domain [IPR017448]", "SREK1, RNA recognition motif 2 [IPR034192]", "SRP9 domain [IPR039432]", "SRSF1, RNA recognition motif 1 [IPR034520]", "SRSF6, RNA recognition motif 1 [IPR034511]", "SRSF7, RNA recognition motif [IPR034651]", "SRSF9, RNA recognition motif 1 [IPR034503]", "SRSF9, RNA recognition motif 2 [IPR034995]", "SSRP1 domain [IPR024954]", "STAG [IPR013721]", "STAM1, SH3 domain [IPR035657]", "STAMBP/STALP-like, MPN domain [IPR044098]", "STAR protein, homodimerisation region [IPR032377]", "STARD7, START domain [IPR041949]", "START domain [IPR002913]", "STAT transcription factor, DNA-binding [IPR013801]", "STAT transcription factor, all-alpha domain [IPR013800]", "STAT transcription factor, protein interaction [IPR013799]", "STAT1, SH2 domain [IPR035859]", "STAT3, SH2 domain [IPR035855]", "STI1 domain [IPR041243]", "STRBP, first double-stranded RNA binding domain [IPR044472]", "SUI1 domain [IPR001950]", "SUMO-activating enzyme subunit 2, C-terminal domain [IPR032426]", "SUN coiled coil domain 2 [IPR040994]", "SUN domain [IPR012919]", "SUN domain-containing protein 1, N-terminal [IPR032680]", "SUZ-C domain [IPR024642]", "SWAP/Surp [IPR000061]", "SWI/SNF-like complex subunit BAF250, C-terminal [IPR033388]", "SWIB/MDM2 domain [IPR003121]", "SWIRM domain [IPR007526]", "Saccharopine dehydrogenase, NADP binding domain [IPR005097]", "Saccharopine dehydrogenase-like, C-terminal [IPR032095]", "Sam68, tyrosine-rich domain [IPR032335]", "Saposin A-type domain [IPR003119]", "Saposin B type domain [IPR008139]", "Saposin B type, region 2 [IPR008138]", "Saposin-like type B, region 1 [IPR007856]", "Sas10 C-terminal domain [IPR018972]", "Schlafen group 3-like, DNA/RNA helicase domain [IPR018647]", "Schlafen, AlbA_2 domain [IPR007421]", "Sec16, central conserved domain [IPR024340]", "Sec23, C-terminal [IPR037550]", "Sec23/Sec24 beta-sandwich [IPR012990]", "Sec23/Sec24, helical domain [IPR006900]", "Sec23/Sec24, trunk domain [IPR006896]", "Sec24-like, trunk domain [IPR041742]", "Sec63 domain [IPR004179]", "Sec7 domain [IPR000904]", "Sec7, C-terminal [IPR015403]", "Sec8 exocyst complex component specific domain [IPR007191]", "Second polo-box domain [IPR033695]", "Sedolisin domain [IPR030400]", "Senescence/spartin-associated, C-terminal [IPR009686]", "Sentrin-specific protease 3/5, conserved domain [IPR045577]", "Septin-type guanine nucleotide-binding (G) domain [IPR030379]", "Sequestosome-1, PB1 domain [IPR034866]", "Sequestosome-1, UBA domain [IPR033741]", "Serine aminopeptidase, S33 [IPR022742]", "Serine hydroxymethyltransferase-like domain [IPR039429]", "Serine-tRNA ligase catalytic core domain [IPR033729]", "Serine-tRNA synthetase, type1, N-terminal [IPR015866]", "Serine-threonine protein phosphatase, N-terminal [IPR031675]", "Serine-threonine/tyrosine-protein kinase, catalytic domain [IPR001245]", "Serine/arginine-rich splicing factor SRSF4-like, RNA recognition motif 1 [IPR035585]", "Serine/threonine-protein PRP4, catalytic domain [IPR044092]", "Serine/threonine-protein kinase N, C2 domain [IPR037784]", "Serine/threonine-protein kinase N, first HR1 domain [IPR037313]", "Serine/threonine-protein kinase N1, second HR1 domain [IPR037317]", "Serine/threonine-protein kinase Nek9, catalytic domain [IPR042767]", "Serine/threonine-protein kinase OSR1/WNK, CCT domain [IPR024678]", "Serine/threonine-protein kinase greatwall, catalytic domain [IPR037638]", "Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase [IPR006186]", "Serpin H1, serpin domain [IPR033830]", "Serpin domain [IPR023796]", "Set2 Rpb1 interacting domain [IPR013257]", "Siah interacting protein, N-terminal [IPR015120]", "Signal recognition particle SRP54, helical bundle [IPR013822]", "Signal recognition particle receptor, alpha subunit, N-terminal [IPR007222]", "Signal recognition particle subunit SRP68, RNA-binding domain [IPR034652]", "Signal recognition particle, SRP54 subunit, GTPase domain [IPR000897]", "Signal recognition particle, SRP54 subunit, M-domain [IPR004125]", "Signal recognition particle, SRP72 subunit, RNA-binding [IPR013699]", "Signal transducer and activation of transcription 1, TAZ2 binding domain, C-terminal [IPR022752]", "Sirtuin family, catalytic core domain [IPR026590]", "Ski2, N-terminal domain [IPR040801]", "Sm-like protein Lsm8 [IPR034103]", "Small G protein signalling modulator 1/2, Rab-binding domain [IPR021935]", "Small GTP-binding protein domain [IPR005225]", "Small acidic protein-like domain [IPR028124]", "Small nuclear ribonucleoprotein D1 [IPR034102]", "Small-subunit processome, Utp12 [IPR007148]", "Small-subunit processome, Utp13 [IPR013934]", "Small-subunit processome, Utp21 [IPR007319]", "Smc1, ATP-binding cassette domain [IPR028468]", "Smc2, ATP-binding cassette domain [IPR027120]", "Snf2, ATP coupling domain [IPR029295]", "Snu114, GTP-binding domain [IPR044121]", "Sof1-like protein [IPR007287]", "Solute carrier family 3 member 2, N-terminal domain [IPR031984]", "Sortilin, C-terminal [IPR031777]", "Sortilin, N-terminal [IPR031778]", "Sorting Nexin 1, PX domain [IPR034901]", "Sorting nexin Vps5-like, C-terminal [IPR015404]", "Sorting nexin protein, WASP-binding domain [IPR019497]", "Sorting nexin, N-terminal [IPR005329]", "Sorting nexin-17/31, FERM domain [IPR040842]", "Sorting nexin-9, BAR domain [IPR037425]", "Sorting nexin-9, PX domain [IPR037426]", "Spen paralogue and orthologue SPOC, C-terminal [IPR012921]", "Spen paralogue/orthologue C-terminal, metazoa [IPR010912]", "Spermidine synthase, tetramerisation domain [IPR035246]", "Splicing factor 1, helix-hairpin domain [IPR032570]", "Splicing factor 3A subunit 1, conserved domain [IPR022030]", "Splicing factor 3A subunit 1, ubiquitin domain [IPR035563]", "Splicing factor 3B subunit 1 [IPR015016]", "Splicing factor ELAV/Hu, RNA recognition motif 1 [IPR034775]", "Splicing factor RBM39, linker [IPR029123]", "Splicing factor SF3a60 /Prp9 subunit, C-terminal [IPR024598]", "Splicing factor SF3a60 binding domain [IPR021966]", "Spp2/MOS2, G-patch domain [IPR026822]", "Spt5 C-terminal domain [IPR024945]", "Spt5 transcription elongation factor, N-terminal [IPR022581]", "Spt5, KOW domain repeat 1 [IPR041973]", "Spt5, KOW domain repeat 2 [IPR041975]", "Spt5, KOW domain repeat 3 [IPR041976]", "Spt5, KOW domain repeat 4 [IPR041977]", "Spt5, KOW domain repeat 5 [IPR041978]", "Spt5, KOW domain repeat 6 [IPR041980]", "Spt6 acidic, N-terminal domain [IPR028083]", "Spt6, SH2 domain [IPR035420]", "Spt6, SH2 domain, C terminus [IPR035018]", "Spt6, SH2 domain, N terminus [IPR035019]", "Squalene cyclase, C-terminal [IPR032696]", "Squalene cyclase, N-terminal [IPR032697]", "Squalene epoxidase [IPR013698]", "Srp40, C-terminal [IPR007718]", "StAR-related lipid transfer protein 3, C-terminal [IPR029867]", "Staphylococcal nuclease (SNase-like), OB-fold [IPR016071]", "Staufen 1, third double-stranded RNA binding domain [IPR044475]", "Staufen 2, first double-stranded RNA binding domain [IPR044476]", "Staufen 2, fourth double-stranded RNA binding domain [IPR044474]", "Staufen 2, second double-stranded RNA binding domain [IPR044464]", "Staufen 2, third double-stranded RNA binding domain [IPR044473]", "Staufen, C-terminal [IPR032478]", "Steadiness box (SB) domain [IPR017916]", "Sterile alpha motif domain [IPR001660]", "Sterol-sensing domain [IPR000731]", "Striatin, N-terminal [IPR013258]", "Strictosidine synthase, conserved region [IPR018119]", "Stromalin conservative domain [IPR020839]", "Structural maintenance of chromosomes 3, ABC domain, eukaryotic [IPR041741]", "Structural maintenance of chromosomes 4, ABC domain, eukaryotic [IPR041738]", "Succinate dehydogenase/fumarate reductase N-terminal [IPR025192]", "Sulfatase, N-terminal [IPR000917]", "Sulphate adenylyltransferase [IPR002650]", "Sulphate adenylyltransferase catalytic domain [IPR024951]", "Suppressor of forked [IPR008847]", "Suppressor of white apricot, N-terminal domain [IPR019147]", "Survival motor neuron [IPR010304]", "Suv3, C-terminal domain 1 [IPR041082]", "Suv3, DEXQ-box helicase domain [IPR044774]", "Suv3, N-terminal [IPR041453]", "Symplekin C-terminal [IPR022075]", "Symplekin/Pta1, N-terminal [IPR032460]", "Synaptic functional regulator FMRP, KH0 domain [IPR040472]", "Synaptotagmin, SMP domain [IPR039010]", "Synaptotagmin-like mitochondrial-lipid-binding domain [IPR031468]", "Synembryn [IPR008376]", "Syntaxin, N-terminal domain [IPR006011]", "Syntaxin-5, N-terminal, Sly1p-binding domain [IPR021538]", "TAP C-terminal (TAP-C) domain [IPR005637]", "TAR DNA-binding protein 43, N-terminal [IPR041105]", "TATA box binding protein associated factor (TAF) [IPR004823]", "TATA-binding protein interacting (TIP20) [IPR013932]", "TBCE, ubiquitin-like (Ubl) domain [IPR044079]", "TCB1D9/TCB1D9B, PH-GRAM domain 1 [IPR036014]", "TCB1D9/TCB1D9B, PH-GRAM domain 2 [IPR036017]", "TFG, PB1 domain [IPR034857]", "TFIIEalpha/SarR/Rpc3 HTH domain [IPR024550]", "TFIIF beta subunit, HTH domain [IPR040450]", "TFIIF, beta subunit, N-terminal [IPR040504]", "TGS [IPR004095]", "THIF-type NAD/FAD binding fold [IPR000594]", "THO complex subunit 2, N-terminal domain [IPR032302]", "THO complex, subunitTHOC2, C-terminal [IPR021418]", "THO complex, subunitTHOC2, N-terminal [IPR021726]", "THUMP domain [IPR004114]", "TIA-1, RNA recognition motif 2 [IPR034830]", "TIA-1, RNA recognition motif 3 [IPR034832]", "TIAR, RNA recognition motif 1 [IPR034492]", "TIAR, RNA recognition motif 2 [IPR034494]", "TIAR, RNA recognition motif 3 [IPR034496]", "TIF1-beta, RING finger, HC subclass [IPR042713]", "TIP49, P-loop domain [IPR010339]", "TOG domain [IPR034085]", "TOPK, catalytic domain [IPR041989]", "TOPRIM domain [IPR006171]", "TPX2 central domain [IPR027330]", "TPX2, C-terminal [IPR027329]", "TRAM/LAG1/CLN8 homology domain [IPR006634]", "TRAM1-like protein [IPR013599]", "TRASH domain [IPR011017]", "TRF2-interacting telomeric protein/Rap1, C-terminal [IPR021661]", "TRIAD supradomain [IPR044066]", "TRIM21, PRY/SPRY domain [IPR035831]", "TRIM25, PRY/SPRY domain [IPR042753]", "TRIM27, PRY/SPRY domain [IPR035791]", "TROVE domain [IPR008858]", "TSG101 and ALIX binding domain of CEP55 [IPR022008]", "TUTase nucleotidyltransferase domain [IPR045100]", "Talin, N-terminal F0 domain [IPR032425]", "Talin, central [IPR015224]", "Talin-1/2, rod-segment [IPR037438]", "Tankyrase 1-binding protein, C-terminal [IPR032764]", "Target SNARE coiled-coil homology domain [IPR000727]", "TatSF1-like, RNA recognition motif 1 [IPR034392]", "Telomere length regulation protein, conserved domain [IPR019337]", "Telomere-associated protein Rif1, N-terminal [IPR022031]", "Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain [IPR020631]", "Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain [IPR020630]", "Tetrapyrrole methylase [IPR000878]", "Tetratricopeptide repeat-like domain [IPR018704]", "Tetratricopeptide, SHNi-TPR domain [IPR019544]", "Tfc3, extended winged-helix domain [IPR035625]", "Thiamine pyrophosphate enzyme, C-terminal TPP-binding [IPR011766]", "Thiamine pyrophosphate enzyme, N-terminal TPP-binding domain [IPR012001]", "Thiamine pyrophosphate enzyme, central domain [IPR012000]", "Thioesterase [IPR001031]", "Thioesterase domain [IPR006683]", "Thiolase, C-terminal [IPR020617]", "Thiolase, N-terminal [IPR020616]", "Thioredoxin domain [IPR013766]", "Thioredoxin domain-containing protein 17-like domain [IPR010357]", "Thioredoxin-like fold [IPR012336]", "Thioredoxin-related transmembrane protein 2, thioredoxin domain [IPR037463]", "Threonine-tRNA ligase catalytic core domain [IPR033728]", "Threonyl/alanyl tRNA synthetase, SAD [IPR012947]", "Thymidylate kinase-like domain [IPR039430]", "Thymidylate synthase/dCMP hydroxymethylase domain [IPR023451]", "Tim10-like [IPR004217]", "Tim44-like domain [IPR007379]", "Toll-interacting protein, C2 domain [IPR037301]", "Toll-interacting protein, CUE domain [IPR041799]", "Topoisomerase I C-terminal domain [IPR025834]", "Trans-isoprenyl diphosphate synthases, head-to-head [IPR033904]", "Transcription elongation factor S-II, central domain [IPR003618]", "Transcription elongation factor Spt6, YqgF domain [IPR028231]", "Transcription elongation factor Spt6, helix-hairpin-helix motif [IPR032706]", "Transcription elongation factor, TFIIS/CRSP70, N-terminal, sub-type [IPR003617]", "Transcription factor CBF/NF-Y/archaeal histone domain [IPR003958]", "Transcription factor CP2, SAM domain [IPR037599]", "Transcription factor IIS, N-terminal [IPR017923]", "Transcription factor TFE/TFIIEalpha HTH domain [IPR017919]", "Transcription factor TFIIB, cyclin-like domain [IPR013150]", "Transcription factor TFIIE alpha subunit, C-terminal [IPR021600]", "Transcription initiation factor IIE subunit alpha, N-terminal [IPR002853]", "Transcription termination and cleavage factor, C-terminal domain [IPR026896]", "Transcriptional coactivator p15 (PC4), C-terminal [IPR003173]", "Transcriptional repressor p66, coiled-coil MBD2-interaction domain [IPR032346]", "Transferrin receptor protein 1/2, PA domain [IPR037324]", "Transferrin receptor-like, dimerisation domain [IPR007365]", "Transforming acidic coiled-coil-containing protein, C-terminal [IPR007707]", "Transketolase, C-terminal domain [IPR033248]", "Transketolase, N-terminal [IPR005474]", "Transketolase-like, pyrimidine-binding domain [IPR005475]", "Translation elongation factor EF1B, beta/delta subunit, guanine nucleotide exchange domain [IPR014038]", "Translation elongation factor EFG/EF2, domain IV [IPR005517]", "Translation elongation factor EFTs/EF1B, dimerisation [IPR014039]", "Translation elongation factor EFTu-like, domain 2 [IPR004161]", "Translation elongation factor EFTu/EF1A, C-terminal [IPR004160]", "Translation elongation factor, IF5A C-terminal [IPR020189]", "Translation initiation factor IF- 2, domain 3 [IPR023115]", "Translation initiation factor IF2/IF5 domain [IPR002735]", "Translation initiation factor eIF-2B subunit epsilon, N-terminal [IPR035543]", "Translation initiation factor eIF-2B subunit epsilon, W2 domain [IPR044123]", "Translation initiation factor, beta propellor-like domain [IPR013979]", "Translational (tr)-type GTP-binding domain [IPR000795]", "Translationally controlled tumour protein (TCTP) domain [IPR034737]", "Translocon Sec61/SecY, plug domain [IPR019561]", "Transmembrane protein 201, C-terminal [IPR018861]", "Treacle protein domain [IPR003993]", "Tripeptidyl-peptidase II domain [IPR034051]", "TrmE-type guanine nucleotide-binding domain [IPR031168]", "TryX and NRX, thioredoxin domain [IPR045870]", "Tubulin binding cofactor C-like domain [IPR012945]", "Tubulin-specific chaperone C, N-terminal [IPR031925]", "Tubulin-specific chaperone D, C-terminal [IPR022577]", "Tubulin/FtsZ, 2-layer sandwich domain [IPR018316]", "Tubulin/FtsZ, GTPase domain [IPR003008]", "Tudor domain [IPR002999]", "Tumour suppressor p53-binding protein-1 Tudor domain [IPR015125]", "Tyrosine-protein kinase BAZ1B, bromodomain [IPR037375]", "Tyrosine-protein kinase, catalytic domain [IPR020635]", "Tyrosine-specific protein phosphatase, PTPase domain [IPR000242]", "Tyrosine-specific protein phosphatases domain [IPR000387]", "U-box domain [IPR003613]", "U1 small nuclear ribonucleoprotein A, RNA recognition motif 1 [IPR034407]", "U1 small nuclear ribonucleoprotein A, RNA recognition motif 2 [IPR034409]", "U1 small nuclear ribonucleoprotein of 70kDa N-terminal [IPR022023]", "U1-C, C2H2-type zinc finger [IPR013085]", "U2 small nuclear ribonucleoprotein B'', RNA recognition motif 2 [IPR034562]", "U2 small nuclear ribonucleoprotein B'', RNA recognition motif 1 [IPR034564]", "U2A'/phosphoprotein 32 family A, C-terminal [IPR003603]", "U3 small nucleolar RNA-associated protein 10, N-terminal [IPR022125]", "U3 small nucleolar RNA-associated protein 15, C-terminal [IPR018983]", "UAS [IPR006577]", "UBX domain [IPR001012]", "UBXN1, UBA domain [IPR041923]", "UDP-glucose/GDP-mannose dehydrogenase, C-terminal [IPR014027]", "UDP-glucose/GDP-mannose dehydrogenase, N-terminal [IPR001732]", "UDP-glucose/GDP-mannose dehydrogenase, dimerisation [IPR014026]", "UDP-glucose:glycoprotein glucosyltransferase, thioredoxin-like domain 4 [IPR040525]", "UGGT, thioredoxin-like domain 1 [IPR040693]", "UGGT, thioredoxin-like domain 2 [IPR040694]", "UGGT, thioredoxin-like domain 3 [IPR040692]", "UHRF1, tandem tudor domain [IPR021991]", "UNC-45/Cro1/She4, central domain [IPR024660]", "UPF0113, PUA domain [IPR005155]", "UPF0113, pre-PUA domain [IPR040598]", "USP8 dimerisation domain [IPR015063]", "UVR domain [IPR001943]", "Ubiquitin E2 variant, N-terminal [IPR008883]", "Ubiquitin carboxyl-terminal hydrolase 47, C-terminal [IPR045578]", "Ubiquitin carboxyl-terminal hydrolase 5, UBA1 domain [IPR041812]", "Ubiquitin carboxyl-terminal hydrolase 7, ICP0-binding domain [IPR024729]", "Ubiquitin carboxyl-terminal hydrolase, C-terminal [IPR029346]", "Ubiquitin conjugation factor E4, core [IPR019474]", "Ubiquitin specific protease domain [IPR028889]", "Ubiquitin system component CUE [IPR003892]", "Ubiquitin-activating enzyme E1, C-terminal [IPR018965]", "Ubiquitin-activating enzyme E1, FCCH domain [IPR032418]", "Ubiquitin-activating enzyme E1, four-helix bundle [IPR032420]", "Ubiquitin-activating enzyme, SCCH domain [IPR019572]", "Ubiquitin-associated domain [IPR015940]", "Ubiquitin-conjugating enzyme E2 [IPR000608]", "Ubiquitin-like domain [IPR000626]", "Ubiquitin-like domain, USP-type [IPR028135]", "Ubiquitin-like modifier-activating enzyme Atg7, N-terminal [IPR032197]", "Ubiquitin-protein ligase E3A, N-terminal zinc-binding domain [IPR032353]", "Ubiquitin-specific peptidase 48 [IPR033841]", "Ubiquitin-specific-processing protease 48, Ubl domain [IPR044743]", "Ubiquitin/SUMO-activating enzyme ubiquitin-like domain [IPR028077]", "Ubiquitinyl hydrolase, variant UBP zinc finger [IPR041432]", "Ubiquitinyl hydrolase-L5 [IPR033837]", "Ulp1 protease family, C-terminal catalytic domain [IPR003653]", "Uncharacterised domain CHP00451 [IPR004521]", "Uncharacterised domain NUC173 [IPR012978]", "Uncharacterised domain NUC202 [IPR012980]", "Uracil-DNA glycosylase-like [IPR005122]", "Uroporphyrinogen decarboxylase (URO-D) [IPR000257]", "Uso1/p115-like vesicle tethering protein, C-terminal [IPR006955]", "VASP tetramerisation [IPR014885]", "VHS domain [IPR002014]", "VIP36, lectin domain [IPR035664]", "VPS10 [IPR006581]", "VPS9 domain [IPR003123]", "Vacuolar protein sorting-associated protein 4, MIT domain [IPR045253]", "Valyl tRNA synthetase, anticodon-binding domain [IPR033705]", "Vertebrate SNX3, PX domain [IPR042137]", "Vertebrate ubiquitin-conjugating enzyme E2 K, UBA domain [IPR042599]", "Vesicle tethering protein Uso1/P115-like , head domain [IPR006953]", "Vesicle transport v-SNARE, N-terminal [IPR007705]", "Vicinal oxygen chelate (VOC) domain [IPR037523]", "Vinculin-binding site-containing domain [IPR015009]", "Virilizer, N-terminal [IPR031801]", "Vitamin B12-dependent methionine synthase, activation domain [IPR004223]", "Vitamin K epoxide reductase [IPR012932]", "Vps16, C-terminal [IPR006925]", "Vps4 oligomerisation, C-terminal [IPR015415]", "Vta1, C-terminal [IPR041212]", "Vta1/callose synthase, N-terminal [IPR039431]", "W2 domain [IPR003307]", "WAPL domain [IPR012502]", "WASH complex subunit 4, N-terminal [IPR028191]", "WASH complex subunit 7, C-terminal [IPR028283]", "WASH complex subunit 7, central domain [IPR028282]", "WD repeat protein mio, zinc-ribbon like domain [IPR031488]", "WD repeat-containing protein 18, C-terminal domain [IPR026987]", "WGR domain [IPR008893]", "WH1/EVH1 domain [IPR000697]", "WH2 domain [IPR003124]", "WHEP-TRS domain [IPR000738]", "WHIM1 domain [IPR028942]", "WHIM2 domain [IPR028941]", "WSTF/Acf1/Cbp146 [IPR013136]", "WW domain [IPR001202]", "WWE domain [IPR004170]", "Wings apart-like protein, C-terminal [IPR022771]", "Wolframin, EF-hand domain [IPR045460]", "Wolframin, OB-fold domain [IPR045461]", "Wolframin, cysteine-rich domain [IPR045400]", "XPC-binding domain [IPR015360]", "XPG, N-terminal [IPR006085]", "XPG-I domain [IPR006086]", "XRCC1, first (central) BRCT domain [IPR045080]", "XRN2-binding (XTBD) domain [IPR021859]", "Xrn1, helical domain [IPR041412]", "YKT6, SNARE motif [IPR045848]", "YTH domain [IPR007275]", "YchF, C-terminal domain [IPR013029]", "YchF, N-terminal [IPR041706]", "YjeF N-terminal domain [IPR004443]", "YqgF/RNase H-like domain [IPR006641]", "YrdC-like domain [IPR006070]", "Z-binding domain [IPR042371]", "ZAP, helix turn helix N-terminal domain [IPR041360]", "ZAP, zinc finger [IPR040954]", "ZC3H15/TMA46 family, C-terminal [IPR032378]", "ZN622/Rei1/Reh1, zinc finger C2H2-type [IPR041661]", "ZO-1, SH3 domain [IPR035597]", "ZU5 domain [IPR000906]", "Zasp-like motif [IPR006643]", "Zinc finger C2H2 AKAP95-type [IPR034736]", "Zinc finger C2H2-type [IPR013087]", "Zinc finger, B-box, chordata [IPR020457]", "Zinc finger, C2H2, LYAR-type [IPR014898]", "Zinc finger, C3HC-like [IPR012935]", "Zinc finger, C3HC4 RING-type [IPR018957]", "Zinc finger, CCCH-type [IPR000571]", "Zinc finger, CCHC-type [IPR001878]", "Zinc finger, CHHC-type [IPR012996]", "Zinc finger, CW-type [IPR011124]", "Zinc finger, CXXC-type [IPR002857]", "Zinc finger, ClpX C4-type [IPR010603]", "Zinc finger, DNA-directed DNA polymerase, family B, alpha [IPR015088]", "Zinc finger, FPG/IleRS-type [IPR010663]", "Zinc finger, FYVE-related [IPR017455]", "Zinc finger, GATA-type [IPR000679]", "Zinc finger, GRF-type [IPR010666]", "Zinc finger, LIM-type [IPR001781]", "Zinc finger, MYM-type [IPR010507]", "Zinc finger, MYND-type [IPR002893]", "Zinc finger, PARP-type [IPR001510]", "Zinc finger, PHD-finger [IPR019787]", "Zinc finger, PHD-type [IPR001965]", "Zinc finger, RING-type [IPR001841]", "Zinc finger, RanBP2-type [IPR001876]", "Zinc finger, Sec23/Sec24-type [IPR006895]", "Zinc finger, TFIIB-type [IPR013137]", "Zinc finger, TFIIS-type [IPR001222]", "Zinc finger, UBP-type [IPR001607]", "Zinc finger, UBR-type [IPR003126]", "Zinc finger, ZPR1-type [IPR004457]", "Zinc finger, ZZ-type [IPR000433]", "Zinc finger, double-stranded RNA binding [IPR022755]", "Zinc knuckle CX2CX3GHX4C [IPR025829]", "Zinc-finger CCCH domain [IPR041686]", "Zn-dependent metallo-hydrolase, RNA specificity domain [IPR011108]", "cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain [IPR003117]", "cGMP-dependent protein kinase, interacting domain [IPR031775]", "dUTPase, trimeric [IPR033704]", "dUTPase-like [IPR029054]", "eIF3 subunit M, C-terminal helix domain [IPR040750]", "eIF3B, RNA recognition motif [IPR034363]", "eIF3G, RNA recognition motif [IPR034240]", "eIF3h, C-terminal [IPR045810]", "eIF4H, RNA recognition motif [IPR034229]", "eRF1 domain 1/Pelota-like [IPR005140]", "eRF1 domain 2 [IPR005141]", "eRF1 domain 3 [IPR005142]", "hnRNP A0, RNA recognition motif 1 [IPR034801]", "hnRNP A1, RNA recognition motif 1 [IPR034845]", "hnRNP A1, RNA recognition motif 2 [IPR034803]", "hnRNP A2/B1, RNA recognition motif 1 [IPR034486]", "hnRNP A3, RNA recognition motif 1 [IPR034513]", "hnRNP A3, RNA recognition motif 2 [IPR034516]", "hnRNP DL, RNA recognition motif 1 [IPR034847]", "hnRNP-L, RNA recognition motif 1 [IPR035005]", "hnRNP-L, RNA recognition motif 2 [IPR035008]", "hnRNP-L, RNA recognition motif 3 [IPR034816]", "hnRNP-L, RNA recognition motif 4 [IPR034817]", "hnRNPAB, RNA recognition motif 1 [IPR034846]", "hnRNPH3, RNA recognition motif 2 [IPR034970]", "hnRNPH3, RNA recognition motif 3 [IPR034969]", "hnRNPM, RNA recognition motif 3 [IPR034990]", "mRNA splicing factor Cwf21 domain [IPR013170]", "mRNA-decapping enzyme, C-terminal [IPR031953]", "p115RhoGEF, RGS domain [IPR037887]", "p21 activated kinase binding domain [IPR033923]", "p21-activated kinase 2, catalytic domain [IPR035064]", "p53 transactivation domain [IPR013872]", "p53, DNA-binding domain [IPR011615]", "p53, tetramerisation domain [IPR010991]", "p54nrb, RNA recognition motif 1 [IPR034552]", "rRNA-processing arch domain [IPR025696]", "snRNP70, RNA recognition motif [IPR034143]", "tRNA methyltransferase TRM10-type domain [IPR028564]", "tRNA methyltransferase TRMD/TRM10-type domain [IPR016009]", "tRNA pseudouridylate synthase B, C-terminal [IPR032819]", "tRNA synthetase, B5-domain [IPR005147]", "tRNA synthetases class I, catalytic domain [IPR032678]", "tRNA(Met) cytidine acetyltransferase TmcA, N-terminal [IPR013562]", "tRNA-binding domain [IPR002547]", "tRNase Z endonuclease [IPR027794]", "v-SNARE, coiled-coil homology domain [IPR042855]", "von Willebrand factor, type A [IPR002035]"], "available_proteins": ["AAR2", "AARS", "AARS2", "AARSD1", "AASDHPPT", "AASS", "AATF", "ABCB1", "ABCB10", "ABCB7", "ABCD3", "ABCE1", "ABCF1", "ABCF2", "ABHD10", "ABHD12", "ABHD14B", "ABHD6", "ACAA2", "ACACA", "ACACB", "ACAD9", "ACADM", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACBD5", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT9", "ACOX1", "ACOX3", "ACP1", "ACSL1", "ACSL3", "ACSL4", "ACTN1", "ACTN2", "ACTN4", "ADA", "ADAR", "ADD1", "ADD3", "ADH5", "ADK", "ADNP", "ADSL", "AFDN", "AFG3L2", "AGK", "AGL", "AGPAT1", "AGPS", "AHCTF1", "AHCY", "AHCYL1", "AHNAK", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK2", "AK4", "AKAP12", "AKAP13", "AKAP8", "AKAP8L", "AKR1A1", "AKR1B1", "AKR7A2", "AKT2", "ALDH18A1", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALG1", "ALKBH5", "ALYREF", "AMOT", "ANAPC1", "ANAPC4", "ANAPC5", "ANK3", "ANKFY1", "ANKHD1", "ANKLE2", "ANLN", "ANP32A", "ANP32B", "AP1B1", "AP1G1", "AP1M1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "APC", "APEH", "APEX1", "APMAP", "APP", "APPL1", "APRT", "AQR", "ARCN1", "ARF4", "ARF5", "ARFGAP1", "ARFIP1", "ARFIP2", "ARHGAP17", "ARHGEF1", "ARHGEF2", "ARID1A", "ARID3B", "ARIH1", "ARL1", "ARL2", "ARL3", "ARL8B", "ARMCX3", "ARMT1", "ASAH1", "ASCC3", "ASNA1", "ASNS", "ASPH", "ATAD1", "ATAD3A", "ATAD3B", "ATAD5", "ATE1", "ATG7", "ATIC", "ATL2", "ATP13A1", "ATP1A1", "ATP2A2", "ATP2B1", "ATP5A1", "ATP5B", "ATP6V1A", "ATP6V1B2", "ATP6V1H", "ATXN10", "ATXN2L", "AUP1", "AURKA", "BAG2", "BAG4", "BAG5", "BAG6", "BAIAP2", "BAP18", "BAZ1A", "BAZ1B", "BCAP31", "BCAS3", "BCS1L", "BIRC6", "BLVRA", "BLVRB", "BMS1", "BOP1", "BPTF", "BRD4", "BRIX1", "BSG", "BTAF1", "BTF3", "BUB1", "BUB1B", "BZW1", "BZW2", "C11orf58", "C1orf35", "CACYBP", "CAD", "CALM3", "CALU", "CAMK2G", "CAND1", "CAP1", "CAPN1", "CAPNS1", "CAPRIN1", "CARHSP1", "CARM1", "CARS", "CARS2", "CASK", "CASP3", "CASP6", "CASP7", "CASP8", "CBX1", "CBX3", "CBX5", "CBX8", "CCAR1", "CCAR2", "CCDC93", "CCNB1", "CD2AP", "CD2BP2", "CD47", "CDC23", "CDC37", "CDC42", "CDC5L", "CDC73", "CDK1", "CDK12", "CDK2", "CDK4", "CDK6", "CDKN2AIP", "CDX2", "CEBPZ", "CELF1", "CENPV", "CEP44", "CEP55", "CERS1", "CERS2", "CETN2", "CFAP20", "CFL1", "CFL2", "CHAC2", "CHAF1B", "CHAMP1", "CHD1", "CHD4", "CHEK2", "CHERP", "CHID1", "CHORDC1", "CHRAC1", "CIAPIN1", "CIRBP", "CISD1", "CISD2", "CIZ1", "CKAP2", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLCN3", "CLIC1", "CLIC4", "CLINT1", "CLPB", "CLPX", "CLTC", "CLUH", "CNDP2", "CNN2", "CNN3", "CNNM3", "CNNM4", "CNOT1", "CNPY2", "COA3", "COASY", "COG2", "COIL", "COLEC12", "COMMD4", "COPA", "COPB1", "COPB2", "COPG1", "COPG2", "COPS2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS7A", "COPS7B", "COPS8", "COPZ1", "COQ8A", "COQ9", "CORO1B", "CORO1C", "COTL1", "COX2", "COX6C", "CPD", "CPNE1", "CPNE3", "CPPED1", "CPSF1", "CPSF2", "CPSF3", "CPSF6", "CPSF7", "CPT1A", "CPT2", "CRKL", "CRMP1", "CRYZ", "CSDE1", "CSE1L", "CSK", "CSNK1A1", "CSNK2A2", "CSTB", "CSTF1", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTDSPL2", "CTNNBL1", "CTPS1", "CTPS2", "CTSC", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4A", "CUL4B", "CUL5", "CWF19L1", "CYB5B", "CYB5D2", "CYB5R3", "CYFIP1", "DAGLB", "DARS", "DARS2", "DAZAP1", "DBN1", "DBNL", "DCAF1", "DCAF13", "DCP1A", "DCTD", "DCTN1", "DCUN1D4", "DCUN1D5", "DDB1", "DDI2", "DDX1", "DDX10", "DDX17", "DDX18", "DDX20", "DDX21", "DDX23", "DDX24", "DDX27", "DDX28", "DDX39A", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX50", "DDX51", "DDX52", "DDX54", "DDX55", "DDX56", "DDX6", "DEK", "DENR", "DFFA", "DHCR24", "DHFR", "DHX15", "DHX16", "DHX30", "DHX36", "DHX37", "DHX38", "DHX8", "DHX9", "DIAPH1", "DIAPH3", "DICER1", "DIDO1", "DIP2B", "DIS3", "DKC1", "DLAT", "DLD", "DLST", "DNAAF5", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC2", "DNAJC3", "DNAJC7", "DNAJC8", "DNAJC9", "DNM1L", "DNM2", "DNMT1", "DNTTIP2", "DOCK7", "DOLPP1", "DPF2", "DPH5", "DPP9", "DPYSL2", "DPYSL3", "DRG1", "DRG2", "DSG2", "DSP", "DST", "DSTN", "DTYMK", "DUSP3", "DUSP9", "DUT", "DYNC1H1", "EARS2", "EBP", "ECE1", "ECI2", "ECSIT", "EDC3", "EDC4", "EDF1", "EEA1", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EEFSEC", "EFL1", "EFTUD2", "EHD1", "EHD4", "EIF2A", "EIF2AK2", "EIF2B3", "EIF2B5", "EIF2D", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "ELAC2", "ELAVL1", "ELOB", "ELOC", "ELP3", "EMC1", "EMD", "EML4", "ENAH", "ENDOD1", "ENO1", "EPB41", "EPB41L2", "EPB41L3", "EPHX1", "EPHX2", "EPRS", "EPS15", "EPS15L1", "ERAL1", "ERAP1", "ERCC2", "ERCC3", "ERGIC2", "ERGIC3", "ERLIN1", "ERLIN2", "ERMP1", "ERP29", "ERP44", "ESF1", "ESYT1", "ESYT2", "ETF1", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXO1", "EXOC1", "EXOC2", "EXOC4", "EXOSC10", "EXOSC3", "EXOSC4", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC8", "EZR", "F11R", "FABP5", "FADS2", "FAF1", "FAF2", "FAH", "FAHD1", "FAM208A", "FAM3C", "FAM49B", "FAM8A1", "FAM91A1", "FANCI", "FAR1", "FARSA", "FARSB", "FASN", "FASTKD2", "FBXO22", "FBXO7", "FDFT1", "FDX1", "FDXR", "FECH", "FEN1", "FERMT2", "FGFR1OP", "FH", "FHL1", "FHOD1", "FIP1L1", "FIS1", "FKBP10", "FKBP14", "FKBP1A", "FKBP3", "FKBP4", "FKBP5", "FKBP7", "FKBP8", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FMR1", "FNDC3A", "FOXC1", "FOXRED1", "FRYL", "FSCN1", "FTO", "FTSJ1", "FTSJ3", "FUBP1", "FUBP3", "FUCA1", "FUCA2", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GALK1", "GALNT2", "GALNT7", "GANAB", "GAPDH", "GAPVD1", "GARS", "GART", "GATAD2A", "GATAD2B", "GATB", "GBA", "GBE1", "GBF1", "GCAT", "GCC2", "GCDH", "GCLM", "GCN1", "GDAP1", "GDPD1", "GEMIN5", "GFM1", "GFPT1", "GGA1", "GGCT", "GGCX", "GHITM", "GIGYF2", "GINS2", "GINS3", "GINS4", "GLA", "GLB1", "GLDC", "GLO1", "GLOD4", "GLRX3", "GLRX5", "GLS", "GLUD1", "GLYR1", "GM2A", "GMDS", "GMFB", "GMPPA", "GMPPB", "GMPS", "GNL1", "GNL2", "GNL3", "GNL3L", "GNPDA1", "GNS", "GOLGB1", "GORASP2", "GOT1", "GOT2", "GPAM", "GPATCH4", "GPATCH8", "GPD2", "GPHN", "GPI", "GPKOW", "GPR89B", "GPS1", "GPT2", "GRB2", "GRHPR", "GRSF1", "GRWD1", "GSK3A", "GSK3B", "GSPT1", "GSR", "GSS", "GSTK1", "GSTM3", "GSTO1", "GSTZ1", "GTF2B", "GTF2E1", "GTF2F2", "GTF3C1", "GTPBP1", "GTPBP10", "GTPBP3", "GTPBP4", "GUSB", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACD3", "HADH", "HADHA", "HADHB", "HAT1", "HBS1L", "HCFC1", "HDAC2", "HDGF", "HDGFL2", "HDLBP", "HEATR1", "HEATR6", "HECTD1", "HELLS", "HEXA", "HEXB", "HGH1", "HGS", "HIBADH", "HIBCH", "HINT2", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HLTF", "HMBS", "HMGB1", "HMGB2", "HMGB3", "HMGCL", "HMGCS1", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HNRNPUL2", "HOOK3", "HP1BP3", "HPRT1", "HSD17B4", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA14", "HSPA4", "HSPA4L", "HSPB1", "HSPBP1", "HSPH1", "HTATSF1", "HUWE1", "IARS", "IARS2", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDI1", "IFT27", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IK", "ILF2", "ILF3", "ILK", "ILKAP", "ILVBL", "IMP3", "IMPDH1", "IMPDH2", "INA", "INF2", "INTS14", "INTS3", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IRGQ", "IRS4", "ISOC1", "ISYNA1", "ITCH", "ITGB1", "IVD", "IWS1", "KARS", "KAT7", "KCTD12", "KCTD5", "KDELC2", "KDM1A", "KDM1B", "KDM2A", "KDM3B", "KHDRBS1", "KHDRBS3", "KHSRP", "KIAA0319L", "KIAA1468", "KIF11", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF3A", "KIF4A", "KIF5B", "KIFC1", "KNOP1", "KPNA1", "KPNA2", "KPNA3", "KPNA6", "KPNB1", "KRI1", "KTN1", "KYAT3", "L1RE1", "L2HGDH", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LASP1", "LBR", "LDHA", "LDHB", "LDLR", "LEMD2", "LEMD3", "LENG8", "LETM1", "LGALS3", "LGALS3BP", "LIG1", "LIG3", "LIMA1", "LIPA", "LLGL1", "LMAN1", "LMAN2", "LMNA", "LMNB1", "LMNB2", "LNPEP", "LNPK", "LONP1", "LPCAT1", "LPP", "LRBA", "LRPAP1", "LRPPRC", "LRRC47", "LSM12", "LSM6", "LSM7", "LSM8", "LSS", "LTA4H", "LYAR", "LYPLA1", "LYRM2", "LZIC", "M6PR", "MACF1", "MAD2L1", "MAGED2", "MAK16", "MAP2K1", "MAP2K2", "MAP2K3", "MAPK1", "MAPK14", "MAPRE1", "MAPRE2", "MARC1", "MARS", "MARS2", "MASTL", "MAT2A", "MAT2B", "MATR3", "MAVS", "MBNL1", "MCAT", "MCCC1", "MCCC2", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCTS1", "MCU", "MDC1", "MDH1", "MDH2", "MDN1", "ME2", "MECP2", "MED1", "METAP1", "METTL13", "MFAP1", "MFN1", "MFN2", "MGME1", "MIA2", "MIA3", "MICU1", "MICU2", "MID1", "MIOS", "MIPEP", "MKI67", "MLEC", "MMAB", "MMS19", "MOGS", "MON2", "MORF4L1", "MOSPD2", "MOV10", "MPP1", "MPP2", "MPP6", "MPRIP", "MPST", "MRC2", "MRE11", "MRPL11", "MRPL12", "MRPL15", "MRPL39", "MRPL43", "MRPL44", "MRPL45", "MRPL48", "MRPL58", "MRPL9", "MRPS23", "MRPS25", "MRPS35", "MRPS5", "MRPS7", "MRTO4", "MSH2", "MSH3", "MSH6", "MSI1", "MSMO1", "MSN", "MSTO1", "MTA1", "MTA2", "MTAP", "MTBP", "MTHFD1", "MTHFD1L", "MTHFD2", "MTOR", "MTPAP", "MTR", "MTX1", "MTX2", "MUT", "MYEF2", "MYH10", "MYH14", "MYH9", "MYL6", "MYO1B", "MYO1D", "MYO6", "NAA10", "NAA40", "NAA50", "NAE1", "NAGK", "NAGLU", "NAMPT", "NANS", "NARS", "NASP", "NAT10", "NAXE", "NBN", "NCAPD2", "NCAPG", "NCBP1", "NCBP2", "NCL", "NCLN", "NCSTN", "NDUFA10", "NDUFA2", "NDUFA8", "NDUFA9", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS7", "NDUFS8", "NDUFV1", "NDUFV2", "NECAP2", "NEFL", "NEFM", "NEK9", "NELFA", "NELFE", "NEMF", "NENF", "NES", "NFKB1", "NFS1", "NHLRC2", "NHP2", "NIFK", "NIP7", "NIPSNAP2", "NISCH", "NKRF", "NKTR", "NLE1", "NLN", "NMD3", "NME1", "NME2", "NMT1", "NNT", "NOC3L", "NOC4L", "NOL10", "NOL11", "NOL6", "NOL7", "NOL8", "NOL9", "NOLC1", "NONO", "NOP2", "NOP56", "NOP58", "NOSIP", "NPC1", "NPEPPS", "NPLOC4", "NPM1", "NRBP1", "NRDC", "NSD2", "NSDHL", "NSF", "NSFL1C", "NSUN2", "NSUN5", "NTPCR", "NUB1", "NUCB1", "NUCB2", "NUDC", "NUDCD1", "NUDCD2", "NUDT1", "NUDT21", "NUDT5", "NUDT9", "NUP133", "NUP153", "NUP155", "NUP188", "NUP210", "NUP214", "NUP35", "NUP50", "NUP54", "NUP62", "NUP98", "NUTF2", "NVL", "NXF1", "NXN", "OCIAD1", "OCLN", "OGDH", "OGT", "OLA1", "OPA1", "OSBP", "OSBPL11", "OSBPL6", "OSBPL8", "OSBPL9", "OSGEP", "OTUB1", "OXA1L", "P3H1", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PACSIN3", "PAFAH1B1", "PAFAH1B3", "PAICS", "PAK1", "PAK2", "PALLD", "PANK4", "PAPSS1", "PARK7", "PARN", "PARP1", "PARP2", "PASK", "PBDC1", "PBK", "PBRM1", "PC", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCID2", "PCK2", "PCLAF", "PCM1", "PCNA", "PCYOX1", "PDAP1", "PDCD11", "PDCD4", "PDCD6", "PDCD6IP", "PDCL3", "PDE12", "PDE4DIP", "PDE6D", "PDHA1", "PDHB", "PDIA3", "PDIA4", "PDIA6", "PDK3", "PDLIM1", "PDLIM5", "PDLIM7", "PDXK", "PEF1", "PELO", "PELP1", "PEPD", "PES1", "PEX14", "PFAS", "PFKL", "PFKM", "PFKP", "PGD", "PGLS", "PGM1", "PGM2", "PGRMC1", "PGRMC2", "PHB", "PHB2", "PHF6", "PHF8", "PHGDH", "PI4K2A", "PI4KB", "PICALM", "PIH1D1", "PIK3C3", "PIN1", "PIN4", "PINX1", "PIP4K2C", "PIR", "PITHD1", "PITRM1", "PKM", "PKMYT1", "PKN1", "PKN2", "PLAA", "PLCG1", "PLD3", "PLD6", "PLEC", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLS3", "PM20D2", "PMPCA", "PMPCB", "PNN", "PNO1", "PNP", "PNPLA8", "PNPT1", "POGZ", "POLA1", "POLA2", "POLD1", "POLDIP2", "POLDIP3", "POLE", "POLE3", "POLE4", "POLR1A", "POLR1B", "POLR1C", "POLR2A", "POLR2B", "POLR2C", "POLR2E", "POLR2G", "POLR3A", "POLRMT", "POP1", "POR", "PPAN", "PPAT", "PPFIA1", "PPIB", "PPID", "PPIE", "PPIF", "PPIH", "PPIL1", "PPIL4", "PPM1G", "PPME1", "PPOX", "PPP1CA", "PPP1CB", "PPP1R10", "PPP1R12A", "PPP1R7", "PPP1R8", "PPP4R3A", "PPP5C", "PPP6C", "PQBP1", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREP", "PREPL", "PRKACA", "PRKAG1", "PRKAR1A", "PRKAR2A", "PRKCSH", "PRKDC", "PRKRA", "PRMT1", "PRMT3", "PRMT5", "PRPF19", "PRPF3", "PRPF31", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPS2", "PRPSAP1", "PRPSAP2", "PRRC1", "PRRC2A", "PRRC2C", "PSAP", "PSAT1", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD11", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD6", "PSMD7", "PSMD8", "PSME1", "PSME2", "PSME3", "PSME4", "PSMF1", "PSPC1", "PTBP1", "PTBP2", "PTCD1", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK7", "PTPN1", "PUF60", "PUM1", "PUM3", "PUS7", "PWP2", "PYCR1", "PYCR2", "QARS", "QKI", "QRSL1", "RAB10", "RAB11B", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB1B", "RAB24", "RAB34", "RAB3GAP1", "RAB3GAP2", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RAB8A", "RAB8B", "RAB9A", "RABEP1", "RABGAP1", "RAC1", "RAD21", "RAD23A", "RAD23B", "RAD50", "RALA", "RALB", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP9", "RANGAP1", "RAPGEF2", "RARS", "RARS2", "RAVER1", "RBBP6", "RBM10", "RBM12", "RBM12B", "RBM14", "RBM17", "RBM19", "RBM22", "RBM25", "RBM26", "RBM27", "RBM28", "RBM3", "RBM34", "RBM39", "RBM4", "RBM42", "RBM4B", "RBM5", "RBM8A", "RBMX", "RBMXL1", "RBPMS", "RCL1", "RCN1", "RCN2", "RDX", "RECQL", "REPS1", "REXO2", "REXO4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RFX1", "RHEB", "RHOA", "RHOG", "RHOT1", "RIC8A", "RIF1", "RIOX2", "RIPK1", "RNASEH2A", "RNF14", "RNF20", "RNF219", "RNF40", "RNPEP", "RNPS1", "ROCK2", "RP2", "RPA1", "RPA2", "RPAP1", "RPAP3", "RPF2", "RPL10", "RPL11", "RPL12", "RPL14", "RPL18", "RPL18A", "RPL19", "RPL23A", "RPL24", "RPL27", "RPL27A", "RPL28", "RPL30", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS2", "RPS20", "RPS3", "RPS4X", "RPS5", "RPS6KA1", "RPS6KA3", "RPS9", "RPSA", "RRBP1", "RRM1", "RRP12", "RSF1", "RTN2", "RTN3", "RTN4", "RTN4IP1", "RUFY1", "RUVBL1", "RUVBL2", "S100A10", "S100A11", "S100A13", "SACM1L", "SAE1", "SAFB", "SAFB2", "SAMHD1", "SAMM50", "SAP130", "SAR1A", "SARNP", "SARS", "SARS2", "SART3", "SBDS", "SC5D", "SCAF4", "SCCPDH", "SCML2", "SCO2", "SCP2", "SCRIB", "SDF4", "SDHA", "SDHB", "SEC11A", "SEC16A", "SEC22B", "SEC23A", "SEC23B", "SEC23IP", "SEC24A", "SEC24B", "SEC24C", "SEC31A", "SEC61A1", "SEC63", "SEL1L", "SENP3", "SEPHS1", "SEPT11", "SEPT2", "SEPT7", "SEPT9", "SERBP1", "SERPINB6", "SERPINH1", "SETD2", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFSWAP", "SGTA", "SH3GL1", "SH3GLB1", "SH3GLB2", "SHCBP1", "SHMT1", "SHMT2", "SIRT1", "SKIV2L", "SKIV2L2", "SKP1", "SKP2", "SLC16A1", "SLC25A12", "SLC25A13", "SLC25A24", "SLC27A4", "SLC2A1", "SLC3A2", "SLC7A1", "SLC9A3R1", "SLFN11", "SLIRP", "SLIT2", "SLK", "SLTM", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCC1", "SMARCC2", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC6", "SMCHD1", "SMN1*", "SMNDC1", "SMU1", "SMYD3", "SMYD4", "SNAP23", "SNAP29", "SND1", "SNRNP200", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPC", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNU13", "SNW1", "SNX1", "SNX12", "SNX17", "SNX2", "SNX27", "SNX3", "SNX5", "SNX6", "SNX9", "SOD2", "SON", "SORD", "SORT1", "SPAG9", "SPART", "SPATA5L1", "SPC25", "SPECC1L", "SPEN", "SPPL2A", "SPTAN1", "SPTBN1", "SPTBN2", "SPTLC1", "SPTLC2", "SQLE", "SQSTM1", "SREK1", "SRI", "SRM", "SRP54", "SRP68", "SRP72", "SRP9", "SRPK1", "SRPRA", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF3", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSRP1", "STAG1", "STAG2", "STAM", "STAMBP", "STARD3", "STARD3NL", "STARD7", "STAT1", "STAT3", "STAU1", "STAU2", "STIP1", "STK4", "STOM", "STOML2", "STRBP", "STRN", "STUB1", "STX12", "STX18", "STX5", "STX7", "STXBP4", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGP2", "SUGT1", "SUN1", "SUPT16H", "SUPT5H", "SUPT6H", "SUPV3L1", "SURF6", "SUZ12", "SV2A", "SYAP1", "SYMPK", "SYNCRIP", "SYNE2", "SYNGR2", "SYNJ2BP", "TACC3", "TAF15", "TAGLN2", "TARDBP", "TARS", "TARS2", "TBC1D10B", "TBC1D13", "TBC1D15", "TBC1D4", "TBC1D9B", "TBCC", "TBCD", "TBCE", "TBL3", "TBRG4", "TCAF1", "TCEA1", "TCERG1", "TCOF1", "TDP2", "TDRKH", "TECR", "TELO2", "TERF2IP", "TEX10", "TFAM", "TFCP2", "TFG", "TFRC", "THOC1", "THOC2", "THOC3", "THOP1", "THUMPD1", "THUMPD3", "TIA1", "TIAL1", "TIMM10", "TIMM44", "TIMM50", "TIMM8B", "TJP1", "TKFC", "TKT", "TLN1", "TMED10", "TMED2", "TMED5", "TMED7", "TMED9", "TMEM104", "TMEM201", "TMEM205", "TMEM97", "TMPO", "TMPO", "TMTC3", "TMX1", "TMX2", "TMX3", "TMX4", "TNKS1BP1", "TNPO1", "TNPO2", "TNPO3", "TOE1", "TOLLIP", "TOP1", "TOP2A", "TOP2B", "TOX4", "TP53", "TP53BP1", "TPP1", "TPP2", "TPR", "TPT1", "TPX2", "TRA2A", "TRA2B", "TRAM1", "TRAP1", "TRIM21", "TRIM24", "TRIM25", "TRIM26", "TRIM27", "TRIM28", "TRIM33", "TRIM35", "TRIP12", "TRIP13", "TRMT10C", "TRMT1L", "TROVE2", "TSFM", "TSG101", "TSR1", "TTC4", "TTF2", "TUBB", "TUBB2A", "TUBB2B", "TUBB4A", "TUBB4B", "TUBB6", "TUBGCP2", "TUBGCP3", "TUFM", "TWF1", "TWF2", "TXNDC12", "TXNDC17", "TXNDC5", "TXNL1", "TXNRD1", "TYMS", "U2AF1", "U2AF2", "U2SURP", "UBA1", "UBA2", "UBA3", "UBA6", "UBAP2", "UBAP2L", "UBE2G2", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2O", "UBE2S", "UBE3A", "UBE4B", "UBFD1", "UBLCP1", "UBQLN4", "UBR4", "UBR5", "UBTF", "UBXN1", "UCHL5", "UGDH", "UGGT1", "UHRF1", "UMPS", "UNC119", "UNC119B", "UNC45A", "UNG", "UPF1", "UQCRC1", "UQCRC2", "URB1", "UROD", "USO1", "USP10", "USP11", "USP14", "USP15", "USP39", "USP47", "USP48", "USP5", "USP7", "USP9X", "UTP15", "UTP20", "UTP3", "UTRN", "VAMP7", "VAPA", "VAPB", "VARS1", "VARS2", "VAT1", "VCP", "VIM", "VIPAS39", "VIRMA", "VKORC1L1", "VPS18", "VPS29", "VPS4B", "VRK1", "VTA1", "VTI1B", "WAPL", "WARS", "WASHC4", "WBP2", "WDHD1", "WDR18", "WDR3", "WDR36", "WDR43", "WDR46", "WFS1", "WIZ", "WNK1", "XPNPEP1", "XPNPEP3", "XPO1", "XPO5", "XPO7", "XPOT", "XRCC1", "XRCC5", "XRCC6", "XRN2", "YARS", "YBX1", "YBX3", "YKT6", "YME1L1", "YRDC", "YTHDC1", "YTHDC2", "YTHDF2", "YTHDF3", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2", "ZC3H11A", "ZC3H14", "ZC3H15", "ZC3H18", "ZC3H7A", "ZC3HAV1", "ZC3HC1", "ZCCHC3", "ZCCHC8", "ZFR", "ZFYVE16", "ZMPSTE24", "ZMYM2", "ZNF207", "ZNF24", "ZNF281", "ZNF318", "ZNF326", "ZNF622", "ZNF638", "ZPR1", "ZYX"], "leading_proteins": ["ABCB1", "ABCB7", "ACOX1", "ACOX3", "ADD1", "AK4", "AKAP8L", "AKT2", "ANK3", "ANKLE2", "APPL1", "ARIH1", "ARMT1", "ATAD3B", "ATP13A1", "ATP2A2", "BUB1", "CALU", "CAMK2G", "CASK", "CBX3", "CBX5", "CDK4", "CERS1", "CERS2", "CLCN3", "CLINT1", "COPG1", "COPS6", "CSE1L", "CSNK1A1", "CTPS1", "CYB5B", "CYB5D2", "DAZAP1", "DCUN1D4", "DICER1", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC2", "DNAJC3", "DNAJC7", "DNAJC8", "DNM2", "DPP9", "DRG1", "DUSP9", "EBP", "EIF4A2", "EIF4B", "ERCC3", "ERGIC3", "ERMP1", "ESF1", "EWSR1", "EXOSC3", "FBXO7", "FKBP14", "FKBP1A", "FKBP7", "FLAD1", "FMR1", "FUBP1", "FUBP3", "FUCA2", "FUS", "FXR2", "GALNT7", "GATAD2A", "GFPT1", "GINS2", "GINS4", "GMPPB", "GNL2", "GPD2", "GRSF1", "GSK3A", "HADH", "HDGFL2", "HLTF", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPM", "HNRNPR", "HNRNPUL1", "HNRNPUL2", "HSD17B4", "HSDL2", "IGF2BP2", "IGF2BP3", "IMPDH1", "INA", "IPO4", "IPO7", "ITCH", "KCTD5", "KHDRBS1", "KHDRBS3", "KHSRP", "KYAT3", "LETM1", "LMAN2", "LMNA", "LMNB2", "LTA4H", "LYRM2", "MAP2K2", "MAPRE1", "MATR3", "MCM2", "MCM3", "MCM5", "MCM6", "MCM7", "MFN1", "MIPEP", "MPP1", "MPP2", "MPP6", "MRC2", "MRPL15", "MRPL39", "MSI1", "MSMO1", "MTA1", "MTA2", "MTX1", "MYEF2", "MYH10", "MYH9", "MYO1D", "NEFL", "NEFM", "NES", "NLN", "NONO", "NPEPPS", "NRDC", "NUCB1", "NUCB2", "OPA1", "OSBPL6", "P3H1", "PABPC4", "PAK1", "PDE6D", "PGRMC2", "PIN1", "PITRM1", "PKMYT1", "PLD3", "PMPCA", "PNPT1", "POLE3", "POLE4", "PPAT", "PREP", "PRRC2A", "PSMD6", "PTK7", "PUF60", "RABGAP1", "RAD23A", "RANBP9", "RARS2", "RAVER1", "RBM10", "RBM14", "RBM27", "RBM3", "RBM4", "RBM4B", "RBMX", "RBPMS", "RCN2", "REXO4", "RIOX2", "RIPK1", "RNPS1", "RPL27A", "RPS20", "RTN4", "RTN4IP1", "SDF4", "SEC23A", "SEC63", "SF1", "SFPQ", "SKP1", "SLC27A4", "SLC2A1", "SNRNP200", "SNRNP70", "SRSF1", "SRSF3", "SRSF9", "STX5", "STX7", "SV2A", "SYNCRIP", "SYNGR2", "TAF15", "TARS2", "TBC1D9B", "TBCE", "TIA1", "TIAL1", "TIMM44", "TMPO", "TRA2A", "TRA2B", "TRIM21", "TRIM24", "TRIM26", "TRIM27", "TUBGCP2", "UBE3A", "UBR5", "UNC119B", "UQCRC2", "USP11", "USP15", "USP7", "VAPA", "VIM", "VTI1B", "YME1L1", "YTHDC1", "YTHDC2", "ZADH2", "ZCCHC3", "ZMYM2", "ZNF326"]} \ No newline at end of file diff --git a/interpro_family/advanced/idx2term.json b/interpro_family/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..9e26dfeeb6e641a33dae4961196235bdb965b21b --- /dev/null +++ b/interpro_family/advanced/idx2term.json @@ -0,0 +1 @@ +{} \ No newline at end of file diff --git a/interpro_family/basic/idx2term.json b/interpro_family/basic/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..e32f7f6d210581116503016c3615191c396c1681 --- /dev/null +++ b/interpro_family/basic/idx2term.json @@ -0,0 +1 @@ +{"0": "Mini-chromosome maintenance protein [IPR031327]"} \ No newline at end of file diff --git a/interpro_family/basic/plot_0.png b/interpro_family/basic/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..fcef0306950246a09918ac4751d89dcc9fc077e4 --- /dev/null +++ b/interpro_family/basic/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:9789e9f1c3001919f6dee639374c1187fe4c7ee290fa4c198816e5f6d990e15c +size 144640 diff --git a/interpro_family/consensus.joblib b/interpro_family/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..8fface8c637675a95d99683d6d0666f9e222de06 --- /dev/null +++ b/interpro_family/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:f8ed1004e8d1c5fcb6e110c5ee23a8becf7be887e30d87b1ac1be40d55ae433f +size 759235 diff --git a/interpro_family/df_merge.tsv b/interpro_family/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..77f6b62f809e5d608cd565398744447906e80d05 --- /dev/null +++ b/interpro_family/df_merge.tsv @@ -0,0 +1,2 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase [IPR001930] 2 5 1.982702643867416 0.0474006541036418 2.121359223300971 5.466019417475728 1.4317001483019938 0.1783942022754649 1.021530403905949 0.5881604361499402 0.986353205880356 0.2226891741813114 0.0003127091156062 0.0006219606051344 0.0025156479029566 0.0007187465088185 0.0053637976870067 diff --git a/interpro_family/metrics.json b/interpro_family/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..dfcd341f780aa42266a39f63efd070742a113fa1 --- /dev/null +++ b/interpro_family/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2734, + "annotations_size": 2150, + "title": "Average number of proteins per term", + "value": 1.2758139534883721 +} \ No newline at end of file diff --git a/interpro_family/paths.json b/interpro_family/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..5926a9cc3a22b780900c033ca2a3c7b0b0ea901f --- /dev/null +++ b/interpro_family/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/interpro_family/fragment/C166/C166_val_log2fc"} \ No newline at end of file diff --git a/interpro_family/result.tsv b/interpro_family/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..e383a712dc9079fd3829a023a6265556df1b90c9 --- /dev/null +++ b/interpro_family/result.tsv @@ -0,0 +1,104 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Mitochondrial inner membrane translocase complex, subunit Tim17 [IPR005678] 0.9981698389458274 3.414204803284116 0.00063968471008 0.7473530452676393 0.0021355933643975 2 Q99595 1 +Transmembrane protein GPR107/GPR108-like [IPR009637] 0.990117130307467 3.379345563859384 0.0007265861669458 0.7904364105336212 0.0023211890920262 2 Q5VW38 1 +V-type ATPase, V0 complex, 116kDa subunit family [IPR002490] 0.9886530014641288 3.3729919096322964 0.0007435613738762 0.797952325773005 0.0023486027609298 2 Q9Y487 1 +ATPase, V0 complex, subunit 116kDa, eukaryotic [IPR026028] 0.9886530014641288 3.3729919096322964 0.0007435613738762 0.797952325773005 0.0023486027609298 2 Q9Y487 1 +CD36 family [IPR002159] 0.9871888726207908 3.3666334339955952 0.0007609176003844 0.8053584421934007 0.0023803571232938 2 Q8WTV0 1 +Mitochondrial carrier UCP-like [IPR002030] 0.971449487554906 3.297973378435241 0.0009738536700736 0.8769058258839089 0.0028328193280857 2 Q9H2D1 1 +Cytochrome P450 [IPR001128] 0.9707174231332374 3.2947661580401117 0.0009850361243994 0.8798328298810868 0.0028542151852545 2 Q16850 1 +Endoplasmic reticulum vesicle transporter [IPR045888] 0.9553440702781858 3.227129615766365 0.0012503880519882 0.9321201768997416 0.0033943615047662 2 Q9Y282 1 +HnRNP R/Q splicing factor [IPR006535] 0.9447291361639828 3.180107967640672 0.0014722018933504 0.95789405310181 0.0038932768397335 2 O60506 1 +Mpv17/PMP22 [IPR007248] 0.9421669106881408 3.168718361589564 0.0015311268496445 0.9629113941988424 0.0039999061078198 2 Q9NR77 1 +Acyl-CoA oxidase [IPR012258] 0.9399707174231352 3.15894353998777 0.0015834216270593 0.9668613370259226 0.0040781670110501 2 O15254 1 +Peroxisomal acyl-coenzyme A oxidase [IPR034171] 0.9399707174231352 3.15894353998777 0.0015834216270593 0.9668613370259226 0.0040781670110501 2 O15254 1 +Haem oxygenase [IPR002051] 0.9344802342606168 3.1344566453683047 0.0017217269368705 0.9753974023511354 0.0043498389121876 2 P30519 1 +Haem oxygenase-like [IPR016053] 0.9344802342606168 3.1344566453683047 0.0017217269368705 0.9753974023511354 0.0043498389121876 2 P30519 1 +Sulfotransferase [IPR005331] 0.926427525622256 3.098413113137906 0.001945600110683 0.9848099517441328 0.0047588626142986 2 Q8NCH0 1 +Cleft lip and palate transmembrane protein 1-like protein [IPR030434] 0.9260614934114224 3.0967710984282704 0.0019564088006198 0.9851595526427456 0.004774436914112 2 O96005 1 +Cleft lip and palate transmembrane 1 [IPR008429] 0.9260614934114224 3.0967710984282704 0.0019564088006198 0.9851595526427456 0.004774436914112 2 O96005 1 +Tetraspanin/Peripherin [IPR018499] 0.9213030746705726 3.075395732778736 0.002102234182352 0.9891605281179724 0.0050331887439385 2 O60637 1 +Tetraspanin, animals [IPR000301] 0.9213030746705726 3.075395732778736 0.002102234182352 0.9891605281179724 0.0050331887439385 2 O60637 1 +Nucleobindin [IPR040250] 0.9169106881405582 3.0556164007092597 0.0022459840327415 0.9920477198597232 0.0052890094965984 2 Q02818 1 +Ergosterol biosynthesis ERG4/ERG24 [IPR001171] 0.91617862371889 3.052315331275125 0.0022708340994908 0.9924623525840486 0.005330014534831 2 Q14739 1 +Defective-in-cullin neddylation protein [IPR014764] 0.8920204978038082 2.9426504424856192 0.003254156293456 0.999095243341326 0.0070104569448201 2 Q92564 1 +ATPase family AAA domain-containing protein 3 [IPR039188] 0.870058565153736 2.841710500903071 0.0044872217932263 0.9999368019506506 0.0090843002405241 2 Q5T9A4 1 +Aminopeptidase N-type [IPR034016] 0.925031226170825 2.6138955797568753 0.0089516390333792 0.99999999598281 0.0158143171090923 3 P55786 1 +Presenilin/signal peptide peptidase [IPR006639] 0.8206442166910757 2.610164453354273 0.0090498705466353 0.9999999967538598 0.0159224399961259 2 Q8TCT9 1 +Peptidase A22B, signal peptide peptidase [IPR007369] 0.8206442166910757 2.610164453354273 0.0090498705466353 0.9999999967538598 0.0159224399961259 2 Q8TCT9 1 +Dephospho-CoA kinase [IPR001977] 0.8195461200585661 2.604948347292086 0.0091888111417888 0.9999999975987364 0.0161273011876293 2 Q13057 1 +Palmitoyl protein thioesterase [IPR002472] 0.8151537335285549 2.5840529687410414 0.009764679661574 0.9999999993120008 0.0169306945745033 2 P50897 1 +Gamma-tubulin complex component protein [IPR007259] 0.8111273792093757 2.564855321067748 0.0103218834425529 0.9999999997948696 0.0177111328024651 2 Q9BSJ2 1 +Porin, eukaryotic type [IPR001925] 0.9051629439765656 2.529512270262932 0.0114221180095279 0.9999999999812322 0.019245731755866 3 P21796,P45880 2 +TAF15/EWS/TLS family [IPR034870] 0.8985719516660564 2.5013403362875732 0.0123724216673462 0.9999999999976265 0.0204620819883033 3 P35637,Q92804 2 +A-kinase anchoring protein 95 (AKAP95) [IPR007071] 0.8945441230318565 2.4840801381691984 0.0129886574424598 0.9999999999993796 0.0212847663881772 3 Q5BKZ1,Q9ULX6 2 +Tricarboxylate/iron carrier [IPR004686] 0.7928257686676466 2.4770671372013235 0.0132466981640766 0.9999999999996464 0.0216088020127198 2 Q6P4A7 1 +Glycoside hydrolase, family 29 [IPR000933] 0.7902635431918014 2.464707866294726 0.0137125000276316 0.999999999999872 0.0222139163229036 2 Q9BTY2 1 +Alpha-L-fucosidase, metazoa-type [IPR016286] 0.7902635431918014 2.464707866294726 0.0137125000276316 0.999999999999872 0.0222139163229036 2 Q9BTY2 1 +Major facilitator, sugar transporter-like [IPR005828] 0.7877013177159644 2.4523316546789267 0.0141933775588873 0.9999999999999551 0.0228411390356346 2 P11166 1 +CTP synthase [IPR004468] 0.7818448023426086 2.4239795568488174 0.0153514696385212 0.9999999999999964 0.0243225200610322 2 P17812 1 +Major facilitator superfamily [IPR011701] 0.7778184480234237 2.404436159227838 0.0161974350595346 0.9999999999999994 0.0254007916688544 2 Q7L0J3 1 +Synthesis of cytochrome c oxidase, Sco1/Sco2 [IPR017276] 0.7521961932650052 2.2790912951473876 0.0226616388691724 1.0 0.0333031603340539 2 O43819 1 +Copper chaperone SCO1/SenC [IPR003782] 0.7521961932650052 2.2790912951473876 0.0226616388691724 1.0 0.0333031603340539 2 O43819 1 +Heterogeneous nuclear ribonucleoprotein C [IPR017347] 0.747437774524156 2.255627630463362 0.0240939613031625 1.0 0.0349541273966258 2 P07910 1 +Nucleosome assembly protein (NAP) [IPR002164] 0.8246063712925668 2.179061151330385 0.0293271257358855 1.0 0.0411575197990561 3 Q01105,Q99733 2 +Syntaxin [IPR045242] 0.8147198828268033 2.135138727459893 0.0327496800618865 1.0 0.0450809068460988 3 O15400,Q13190 2 +Peptidase, FtsH [IPR005936] 0.7112005856515367 2.07506734646775 0.0379802935448947 1.0 0.051067936911522 2 Q96TA2 1 +Dynamin [IPR022812] 0.7898205785426584 2.0236588312045947 0.0430052672692338 1.0 0.0564821775374787 3 P50570,O60313 2 +Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase [IPR001930] 0.8708154093864938 1.982702643867416 0.0474006541036418 1.0 0.0610247942052873 5 P09960,P55786 2 +Eukaryotic porin/Tom40 [IPR027246] 0.8681318681318687 1.978886611067617 0.0478287740355178 1.0 0.0614724474813663 4 P21796,P45880,Q9Y277 3 +Peptidase T1A, proteasome beta-subunit [IPR000243] 0.7778844571722308 1.9697904482087765 0.0488623917413282 1.0 0.0624578729154908 3 Q99436 1 +Peptidase S9A, prolyl oligopeptidase [IPR002470] 0.6855783308931214 1.9454534854335976 0.0517204228234053 1.0 0.0654111229825421 2 P48147 1 +Polyadenylate binding protein, human types 1, 2, 3, 4 [IPR006515] 0.6844802342606151 1.939863974417845 0.0523962232972206 1.0 0.0660033974343465 2 Q13310 1 +Calcium uptake protein 1/2/3 [IPR039800] 0.6782576866764357 1.908137816133986 0.0563734061788463 1.0 0.0700999556301443 2 Q8IYU8 1 +Proteasome B-type subunit [IPR023333] 0.7762998158421044 1.8511695492506948 0.0641451650197588 1.0 0.0780929245710541 7 Q99436,P28070,P28072,P49721 4 +SCAMP [IPR007273] 0.7511345577755499 1.8481003069415944 0.0645878334030736 1.0 0.0784984973525202 3 O15126 1 +Microtubule-associated protein RP/EB [IPR027328] 0.6647144948755506 1.8387863963260735 0.0659466099110703 1.0 0.0797442133345339 2 Q15691 1 +Prefoldin alpha-like [IPR004127] 0.6599560761347014 1.814324817282321 0.0696277329725554 1.0 0.0834911466207441 2 P61758 1 +DnaJ homolog subfamily A member 1/2-like [IPR044713] 0.647877013177166 1.752017977603039 0.0797707166935715 1.0 0.0930586222958105 2 O60884 1 +P-type ATPase [IPR001757] 0.8122437610377673 1.7486779738223428 0.0803466994978006 1.0 0.0936289452142391 4 Q9HD20 1 +26S proteasome regulatory subunit Rpn7/COP9 signalosome complex subunit 1 [IPR019585] 0.6456808199121546 1.7406578022660903 0.0817435791343914 1.0 0.0949479714418917 2 Q15008 1 +Flotillin family [IPR027705] 0.6383601756954641 1.7027230508581404 0.088619909015529 1.0 0.1014551674032947 2 O75955 1 +Inosine-5'-monophosphate dehydrogenase [IPR005990] 0.637628111273795 1.6989239879322937 0.0893335065886797 1.0 0.1020547498223493 2 P20839 1 +KH domain-containing BBP-like [IPR045071] 0.7975869164252112 1.6875758040948092 0.0914926871447028 1.0 0.103968962664435 4 O75525,Q07666 2 +Peptidase M3A/M3B [IPR045090] 0.715488831929696 1.6840112267177387 0.0921794990835893 1.0 0.1045836005433863 3 Q9BYT8,Q99797 2 +Type 1 protein exporter [IPR039421] 0.7132298423001486 1.673544397080453 0.0942201741154427 1.0 0.1064585681427217 3 P08183 1 +Protein PRRC2 [IPR033184] 0.6317715959004424 1.668496072164386 0.0952172910064252 1.0 0.1074067028666392 2 P48634 1 +Ribosomal protein L15 [IPR030878] 0.6306734992679389 1.6627839630137116 0.0963556879231606 1.0 0.1084064516142309 2 P46776 1 +Phosphatidylinositol transfer protein [IPR001666] 0.6226207906295791 1.6208314828892088 0.1050537845435699 1.0 0.1165457362067468 2 P48739 1 +Kinesin light chain [IPR002151] 0.7014225690722845 1.6187166718019603 0.1055082380835599 1.0 0.1168689911796258 3 Q9H0B6 1 +Proteasome, subunit alpha/beta [IPR001353] 0.5588130477113148 1.6094029160521646 0.107528268078302 1.0 0.118687532295469 14 Q99436,P28070,P28072,P49721 4 +HAD-superfamily hydrolase, subfamily IG, 5'-nucleotidase [IPR008380] 0.667390118897576 1.459701104569274 0.1443722382083803 1.0 0.1534356461433601 3 Q9H857 1 +Prefoldin beta-like [IPR002777] 0.6609300622482608 1.429381839825669 0.1528945150970724 1.0 0.1621722779766678 3 Q9UHV9,Q9NQP4 2 +Chaperone DnaJ [IPR012724] 0.6481142438667156 1.369140279736282 0.1709554294721667 1.0 0.1807050999828704 3 O60884,Q96EY1 2 +Mitotic spindle checkpoint protein Bub1/Mad3 [IPR015661] 0.5647877013177229 1.3170303465264306 0.1878284526913822 1.0 0.1978594675582909 2 O43683 1 +Caspase-3/7 [IPR015471] 0.5603953147877062 1.2938513928530744 0.1957167568468838 1.0 0.2058664516735813 2 P55210 1 +Fragile X mental retardation syndrome-related protein [IPR040148] 0.6314808547114661 1.2908267567078424 0.1967637575070089 1.0 0.2068665421222832 3 Q06787 1 +Flagellum site-determining protein YlxH/ Fe-S cluster assembling factor NBP35 [IPR033756] 0.5527086383601807 1.253284082974449 0.2101023389981524 1.0 0.220458774449013 2 Q9Y5Y2 1 +Mrp/NBP35 ATP-binding protein [IPR019591] 0.5527086383601807 1.253284082974449 0.2101023389981524 1.0 0.220458774449013 2 Q9Y5Y2 1 +Developmentally regulated GTP-binding protein [IPR045001] 0.5223279648609146 1.0932141441783785 0.274299788293709 1.0 0.2861448543578236 2 Q9Y295 1 +S-phase kinase-associated protein 1-like [IPR001232] 0.5208638360175764 1.0855242733993336 0.2776895188981192 1.0 0.289540477997554 2 P63208 1 +THRAP3/BCLAF1 family [IPR029199] 0.5142752562225474 1.05096456762886 0.2932748635762148 1.0 0.3050512610976593 2 Q9NYF8 1 +Tumour protein D52 [IPR007327] 0.5117130307467103 1.0375467554059166 0.2994811174767986 1.0 0.3112056078178429 2 P55327 1 +Oxysterol-binding protein [IPR000648] 0.6416312435260497 1.0167422581624548 0.309276057200115 1.0 0.3212287550629213 5 Q9BZF3 1 +Sorting nexin-5/6/32 [IPR014637] 0.5018301610541794 0.985931107148732 0.3241669208432691 1.0 0.3355603658223537 2 Q9Y5X3 1 +Glutathione Transferase family [IPR040079] 0.5509930041359148 0.9663665386049256 0.3338608015965183 1.0 0.3454286445777259 9 Q13505,O75431 2 +UV excision repair protein Rad23 [IPR004806] 0.4952415812591604 0.9516647932093932 0.3412670099979817 1.0 0.3525824466581743 2 P54725 1 +E3 ubiquitin ligase RBR family [IPR031127] 0.4901171303074783 0.9251073922742814 0.3549100482194598 1.0 0.3657989471101815 2 Q9Y4X5 1 +Protein transport protein Sec23 [IPR037364] 0.4886530014641365 0.917536201597041 0.3588617317704949 1.0 0.3696946446126326 2 Q15436 1 +Short-chain dehydrogenase/reductase SDR [IPR002347] 0.4159973369361099 0.9090021889498336 0.3633489703597412 1.0 0.3741380681386224 17 Q06136,Q3SXM5 2 +Mesoderm induction early response protein/metastasis-associated protein [IPR040138] 0.4853587115666288 0.9005299666468155 0.3678382853412578 1.0 0.3782172709152101 2 Q13330 1 +Protein arginine N-methyltransferase [IPR025799] 0.5941738140163758 0.8169741411139001 0.4139432058904675 1.0 0.4244052897780186 5 Q86X55,Q6P2P2 2 +Arginine-tRNA ligase [IPR001278] 0.4418008784773016 0.6808188891854224 0.4959860962861477 1.0 0.5070709020519342 2 Q5T160 1 +Eukaryotic translation initiation factor 3 subunit M eIF3m/COP9 signalosome complex subunit 7 COPS7 [IPR045237] 0.4489198095935556 0.4675310256830204 0.6401199999397127 1.0 0.6510208135621487 3 Q9H9Q2,Q7L2H7 2 +G-protein alpha subunit, group I [IPR001408] 0.4408641523251556 0.4357999537663605 0.6629818774033869 1.0 0.6719935500851907 3 P08754,P04899 2 +Ribonuclease CAF1 [IPR006941] 0.4225558403515199 0.3665422997147667 0.7139604548304272 1.0 0.7220202153741386 3 Q9UIV1,O95453 2 +Mitochondrial carrier protein [IPR002067] 0.4248020867864738 0.3650707231942639 0.7150586143959583 1.0 0.7227907949935639 9 Q9UJS0,P05141,P53007,P12236 4 +Bcl-2 family [IPR026298] 0.4179296298230108 0.3497275554407131 0.7265431717768385 1.0 0.7337096380085498 3 Q07820 1 +Bcl2-like [IPR002475] 0.4179296298230108 0.3497275554407131 0.7265431717768385 1.0 0.7337096380085498 3 Q07820 1 +Adenylate kinase subfamily [IPR006259] 0.356881405563685 0.3064277704415185 0.7592789668962632 1.0 0.7660486995903171 2 P27144 1 +Coatomer gamma subunit [IPR017106] 0.3495607613469923 0.2795229572535964 0.7798435225171203 1.0 0.7860588717354939 2 Q9Y678 1 +YTH domain containing protein [IPR045168] 0.3954595386305384 0.2724695417288908 0.785261007803842 1.0 0.7907780640647589 3 Q96MU7,Q9Y5A9 2 +ADP/ATP carrier protein, eukaryotic type [IPR002113] 0.3833359188225014 0.2340998970185683 0.8149074258783542 1.0 0.8190981606537922 3 P12236 1 +CPSF6/7 family [IPR034772] 0.321010248901898 0.1855829376189035 0.8527718349249342 1.0 0.8567567500414058 2 Q8N684 1 +Mini-chromosome maintenance protein [IPR031327] 0.3907624633431089 0.1482615861781141 0.8821363300490748 1.0 0.8850177832970185 6 P49736,Q14566,P25205,P33993,P33992 5 +Enoyl-CoA hydratase/isomerase [IPR001753] 0.3744642848367546 0.1061062680811554 0.915498038013728 1.0 0.9176320660743662 6 Q13011 1 diff --git a/interpro_family/selections.json b/interpro_family/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..11ee04890934fc1dae92a978dfcfc0305916b941 --- /dev/null +++ b/interpro_family/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["-alpha-acetyltransferase 35, NatC auxiliary subunit [IPR007244]", "1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase, eukaryotes [IPR027496]", "1,4-alpha-glucan-branching enzyme [IPR037439]", "1-Cys peroxiredoxin [IPR045020]", "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [IPR028380]", "14-3-3 protein [IPR000308]", "14-3-3 theta [IPR042584]", "2-amino-3-ketobutyrate coenzyme A ligase [IPR011282]", "2-deoxynucleoside 5-phosphate N-hydrolase 1, DNPH1 [IPR028607]", "2-oxoglutarate dehydrogenase E1 component [IPR011603]", "2-phosphoglycolate phosphatase, eukaryotic [IPR006349]", "26S Proteasome non-ATPase regulatory subunit 1 [IPR035266]", "26S Proteasome non-ATPase regulatory subunit 11 [IPR035295]", "26S Proteasome non-ATPase regulatory subunit 12 [IPR035297]", "26S Proteasome non-ATPase regulatory subunit 12/COP9 signalosome complex subunit 4 [IPR040134]", "26S Proteasome non-ATPase regulatory subunit 13 [IPR035298]", "26S Proteasome non-ATPase regulatory subunit 14 [IPR035299]", "26S Proteasome non-ATPase regulatory subunit 6 [IPR035268]", "26S Proteasome non-ATPase regulatory subunit 7/8 [IPR033858]", "26S Proteasome regulatory subunit 4 [IPR035244]", "26S Proteasome regulatory subunit 6A [IPR035254]", "26S Proteasome regulatory subunit 6B [IPR035256]", "26S Proteasome regulatory subunit 7 [IPR035245]", "26S proteasome non-ATPase regulatory subunit 10-like [IPR039334]", "26S proteasome non-ATPase regulatory subunit 3 [IPR035267]", "26S proteasome non-ATPase regulatory subunit Rpn12 [IPR006746]", "26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit [IPR016643]", "26S proteasome regulatory complex, non-ATPase subcomplex, Rpn2/Psmd1 subunit [IPR016642]", "26S proteasome regulatory subunit 10B [IPR035263]", "26S proteasome regulatory subunit P45-like [IPR005937]", "26S proteasome regulatory subunit Rpn7/COP9 signalosome complex subunit 1 [IPR019585]", "28S ribosomal protein S17, mitochondrial [IPR039193]", "28S ribosomal protein S25, mitochondrial [IPR040049]", "28S ribosomal protein S27, mitochondrial [IPR019266]", "28kDa heat- and acid-stable phosphoprotein [IPR039876]", "3'-5' RNA helicase YTHDC2-like [IPR031083]", "3-hydroxyacyl-CoA dehydrogenase [IPR022694]", "3-hydroxyisobutyrate dehydrogenase [IPR011548]", "3-hydroxyisobutyrate dehydrogenase-related [IPR015815]", "3-ketodihydrosphingosine reductase KDSR-like [IPR045022]", "3-oxo-5-alpha-steroid 4-dehydrogenase/very-long-chain enoyl-CoA reductase [IPR039357]", "39S ribosomal protein L40, mitochondrial [IPR039145]", "39S ribosomal protein L43/54S ribosomal protein L51 [IPR039927]", "40S Ribosomal protein S10 [IPR037447]", "40S ribosomal protein S1/3, eukaryotes [IPR027500]", "40S ribosomal protein SA [IPR027504]", "4F2 cell-surface antigen heavy chain [IPR042280]", "5'-3' exoribonuclease [IPR027073]", "5'-3' exoribonuclease type 2 [IPR017151]", "5'-AMP-activated protein kinase subunit gamma-1 [IPR039166]", "5-lipoxygenase-activating protein [IPR001446]", "50S ribosomal protein L18Ae/60S ribosomal protein L20 and L18a [IPR028877]", "6-Phosphogluconolactonase [IPR039104]", "6-phosphogluconate dehydrogenase [IPR006183]", "6-phosphogluconate dehydrogenase, decarboxylating [IPR006113]", "60S acidic ribosomal protein P0 [IPR030670]", "60S ribosomal protein L18a/ L20, eukaryotes [IPR021138]", "60S ribosomal protein L19 [IPR039547]", "60S ribosomal protein L35 [IPR045059]", "60S ribosomal protein L6E [IPR000915]", "60kDa SS-A/Ro ribonucleoprotein [IPR040322]", "A-kinase anchor protein 12 [IPR028540]", "A-kinase anchor protein 13 [IPR028852]", "A-kinase anchoring protein 95 (AKAP95) [IPR007071]", "A1 cistron-splicing factor, AAR2 [IPR007946]", "AAA ATPase, CDC48 family [IPR005938]", "ADF/Cofilin [IPR017904]", "ADP-ribose pyrophosphatase, mitochondrial [IPR039989]", "ADP-ribosylation factor 1-5 [IPR045872]", "ADP-ribosylation factor-like protein 2 [IPR045873]", "ADP-ribosylation factor-like protein 2/3 [IPR044612]", "ADP-ribosylation factor-like protein 6-interacting protein 1 [IPR033301]", "ADP-ribosylation factor-like protein 8A/8B [IPR044154]", "ADP-ribosylation/Crystallin J1 [IPR005502]", "ADP-specific phosphofructokinase/glucokinase [IPR007666]", "ADP/ATP carrier protein, eukaryotic type [IPR002113]", "AH receptor-interacting protein [IPR031208]", "AIP/AIPL1 [IPR039663]", "AP complex subunit beta [IPR026739]", "AP endonuclease 1 [IPR004808]", "AP-1/2/4 complex subunit beta [IPR016342]", "AP-2 complex subunit sigma [IPR027156]", "AP-3 complex subunit beta [IPR026740]", "AT-rich interactive domain-containing protein 3 [IPR045147]", "ATP synthase membrane subunit K [IPR009125]", "ATP synthase, F0 complex, subunit B [IPR013837]", "ATP synthase, F0 complex, subunit B/MI25 [IPR008688]", "ATP synthase, F0 complex, subunit D, mitochondrial [IPR008689]", "ATP synthase, F0 complex, subunit E, mitochondrial [IPR008386]", "ATP synthase, F0 complex, subunit G, mitochondrial [IPR006808]", "ATP synthase, F1 complex, alpha subunit [IPR005294]", "ATP synthase, F1 complex, beta subunit [IPR005722]", "ATP synthase, F1 complex, gamma subunit [IPR000131]", "ATP-binding cassette subfamily B member 10-like [IPR030260]", "ATP-citrate synthase [IPR014608]", "ATP-dependent 6-phosphofructokinase [IPR022953]", "ATP-dependent 6-phosphofructokinase, eukaryotic-type [IPR009161]", "ATP-dependent 6-phosphofructokinase, vertebrate-type [IPR041914]", "ATP-dependent Clp protease proteolytic subunit [IPR001907]", "ATP-dependent RNA helicase Ski2-like [IPR016438]", "ATP-dependent helicase Rad3/Chl1-like [IPR013020]", "ATP11 [IPR010591]", "ATP:cob(I)alamin adenosyltransferase, PduO-type [IPR029499]", "ATP:guanido phosphotransferase [IPR000749]", "ATPase family AAA domain-containing protein 3 [IPR039188]", "ATPase, OSCP/delta subunit [IPR000711]", "ATPase, V0 complex, c/d subunit [IPR002843]", "ATPase, V0 complex, subunit 116kDa, eukaryotic [IPR026028]", "ATPase, V0 complex, subunit d [IPR016727]", "ATPase, V1 complex, subunit A [IPR005725]", "ATPase, V1 complex, subunit B [IPR005723]", "ATPase, V1 complex, subunit C [IPR004907]", "ATPase, V1 complex, subunit D [IPR002699]", "ATPase, V1 complex, subunit H [IPR004908]", "ATPase, vacuolar ER assembly factor, Vma12 [IPR021013]", "Acetyl-coenzyme A transporter 1-like [IPR024371]", "Acid ceramidase-like [IPR016699]", "Acidic leucine-rich nuclear phosphoprotein 32 [IPR045081]", "Acireductone dioxygenase ARD family [IPR004313]", "Aconitase, mitochondrial-like [IPR006248]", "Aconitase/Iron-responsive element-binding protein 2 [IPR006249]", "Actin family [IPR004000]", "Actin-related protein 10 [IPR027127]", "Actin-related protein 2/3 complex subunit 1 [IPR017383]", "Actin-related protein 2/3 complex subunit 1A [IPR030140]", "Actin-related protein 2/3 complex subunit 2 [IPR007188]", "Actin-related protein 2/3 complex subunit 3 [IPR007204]", "Actin-related protein 2/3 complex subunit 4 [IPR008384]", "Actin-related protein 2/3 complex subunit 5 [IPR006789]", "Actin-related protein 3 [IPR015623]", "Activator of 90kDa heat shock protein ATPase-like [IPR039981]", "Activator of Hsp90 ATPase homologue 1-like [IPR013538]", "Activity-dependent neuroprotector homeobox protein [IPR038861]", "Acyl-CoA desaturase [IPR015876]", "Acyl-CoA oxidase [IPR012258]", "Acyl-CoA thioesterase [IPR003703]", "Acyl-CoA-binding domain-containing protein 5 [IPR016347]", "Acyl-coenzyme A thioesterase 13 [IPR039298]", "Acyltransferase ChoActase/COT/CPT [IPR000542]", "Adaptor protein complex AP-1, gamma subunit [IPR017107]", "Adaptor protein complex AP-2, alpha subunit [IPR017104]", "Adaptor protein complex AP-3, delta subunit [IPR017105]", "Adaptor protein complex, sigma subunit [IPR016635]", "Adenine phosphoribosyl transferase [IPR005764]", "Adenomatous polyposis coli (APC) family [IPR026818]", "Adenomatous polyposis coli [IPR026836]", "Adenosine deaminase [IPR028893]", "Adenosine kinase [IPR001805]", "Adenosine/adenine deaminase [IPR006330]", "Adenosylhomocysteinase-like [IPR000043]", "Adenylate cyclase-associated CAP [IPR001837]", "Adenylate kinase 2 [IPR028587]", "Adenylate kinase 3/4, mitochondrial [IPR028586]", "Adenylate kinase 4, mitochondrial [IPR028585]", "Adenylate kinase isoenzyme 1 [IPR028582]", "Adenylate kinase isoenzyme 6 [IPR020618]", "Adenylate kinase subfamily [IPR006259]", "Adenylate kinase, isozyme 1/5 [IPR006267]", "Adenylate kinase/UMP-CMP kinase [IPR000850]", "Adenylosuccinate lyase [IPR004769]", "Adenylosuccinate synthetase [IPR001114]", "Adenylosuccinate synthetase isozyme 2, chordates [IPR027529]", "Adenylyl cyclase-associated protein CAP1 [IPR028415]", "Adenylyl-sulfate kinase [IPR002891]", "AdoMet-dependent rRNA methyltransferase Spb1-like [IPR028589]", "Adrenodoxin [IPR001055]", "Aladin [IPR045139]", "Alanine-tRNA ligase, class IIc [IPR002318]", "Alanine-tRNA ligase, eukaryota/bacteria [IPR023033]", "Alcohol dehydrogenase class III [IPR014183]", "Aldehyde dehydrogenase NAD(P)-dependent [IPR012394]", "Aldehyde dehydrogenase family 7 member A1-like [IPR044638]", "Aldo-keto reductase [IPR020471]", "Aldo-keto reductase family 1 member A1 [IPR044481]", "Alkyldihydroxyacetonephosphate synthase [IPR025650]", "Alpha E-catenin/Alpha T-catenin [IPR030047]", "Alpha crystallin/Small heat shock protein, animal type [IPR001436]", "Alpha-2-macroglobulin receptor-associated protein [IPR038003]", "Alpha-D-phosphohexomutase superfamily [IPR005841]", "Alpha-L-fucosidase, metazoa-type [IPR016286]", "Alpha-N-acetylglucosaminidase [IPR007781]", "Alpha-N-methyltransferase NTM1 [IPR008576]", "Alpha-adducin [IPR027766]", "Alpha-catenin [IPR001033]", "Alpha-internexin [IPR027703]", "Alpha-ketoglutarate-dependent dioxygenase FTO [IPR032868]", "Amidase [IPR000120]", "Amidophosphoribosyltransferase [IPR005854]", "Amino acid/polyamine transporter I [IPR002293]", "Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 [IPR042360]", "Aminoacyl-tRNA synthetase, class Ic [IPR002305]", "Aminopeptidase N-type [IPR034016]", "Aminopeptidase, leukotriene A4 hydrolase-like [IPR034015]", "Aminotransferase ALAT1/2-like [IPR045088]", "Aminotransferase class-III [IPR005814]", "AmpG-like permease/Acetyl-coenzyme A transporter 1 [IPR004752]", "Amyloid-beta precursor protein [IPR028866]", "Amyloidogenic glycoprotein [IPR008155]", "Anamorsin [IPR007785]", "Anaphase-promoting complex subunit 1 [IPR024990]", "Anaphase-promoting complex subunit 16 [IPR029641]", "Anaphase-promoting complex subunit 4 [IPR024789]", "Anaphase-promoting complex subunit 4, metazoa [IPR017169]", "Anaphase-promoting complex subunit 5 [IPR037679]", "Ancient conserved domain protein family [IPR045095]", "Angiomotin [IPR009114]", "Ankycorbin [IPR042420]", "Ankyrin repeat and LEM domain-containing protein 2 [IPR035007]", "Annexin A1 [IPR002388]", "Annexin A11 [IPR008157]", "Annexin A2 [IPR002389]", "Annexin A6 [IPR002393]", "Annexin [IPR001464]", "Antifreeze, type III [IPR006013]", "Apolipoprotein L [IPR008405]", "Apoptosis inhibitory 5 [IPR008383]", "Apoptosis regulator BAK [IPR026308]", "Apoptosis regulator, Mcl-1 [IPR013281]", "Arfaptin family [IPR030798]", "Arfaptin-1 [IPR030793]", "Arginine-tRNA ligase [IPR001278]", "Arginine-tRNA-protein transferase 1, eukaryotic [IPR017137]", "Armadillo repeat-containing protein 6 [IPR040104]", "Armadillo-type fold containing protein ARMC8/Vid28 [IPR038739]", "Arsenical pump ATPase, ArsA/GET3 [IPR016300]", "Arsenical pump ATPase, ArsA/GET3, eukaryotic [IPR027542]", "Arylesterase [IPR002640]", "Asparagine synthase, glutamine-hydrolyzing [IPR006426]", "Asparagine-tRNA ligase [IPR004522]", "Asparaginyl endopeptidase [IPR043577]", "Aspartate carbamoyltransferase [IPR002082]", "Aspartate-tRNA ligase, type 1 [IPR004524]", "Aspartate-tRNA synthetase, type 2 [IPR004523]", "Aspartate/ornithine carbamoyltransferase [IPR006130]", "Aspartate/other aminotransferase [IPR000796]", "Aspartyl/Asparaginyl-tRNA synthetase, class IIb [IPR002312]", "Aspartyl/asparaginyl beta-hydroxylase family [IPR039038]", "Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, B subunit [IPR004413]", "Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, subunit B /E [IPR017959]", "Associate of Myc 1 [IPR026060]", "Ataxin2-like [IPR045117]", "Atypical dual specificity phosphatase, subfamily A [IPR020405]", "Atypical kinase COQ8A [IPR034640]", "Aurora kinase [IPR030616]", "Autophagy protein Atg8 ubiquitin-like [IPR004241]", "B-cell receptor-associated protein 29/31 [IPR008417]", "BAG family molecular chaperone regulator 2 [IPR037689]", "BBP/SF1 family [IPR031150]", "BCAS3-like [IPR045142]", "BCP1 family [IPR025602]", "BRCA1-associated ATM activator 1 [IPR038904]", "BRI3-binding protein [IPR033367]", "BRISC and BRCA1-A complex member 1 [IPR026126]", "Bacterial/eukaryotic lysine-tRNA ligase, class II [IPR034762]", "Baculoviral IAP repeat-containing protein 6 [IPR022103]", "Band 4.1 protein, chordates [IPR021187]", "Band 4.1-like protein 2 [IPR030546]", "Band 4.1-like protein 3 [IPR030691]", "Band-7 stomatin-like [IPR043202]", "Barrier- to-autointegration factor, BAF [IPR004122]", "Basigin [IPR044157]", "Basigin-like [IPR043204]", "Bax inhibitor 1-related [IPR006214]", "Bcl-2 family [IPR026298]", "Bcl-2-associated transcription factor 1 [IPR026668]", "Bcl-2-like protein 13 [IPR042398]", "Bcl2-like [IPR002475]", "Beta tubulin [IPR002453]", "Beta-1,4-glucuronyltransferase 1 [IPR043189]", "Beta-N-acetylglucosaminidase [IPR011496]", "Beta-catenin [IPR013284]", "Beta-catenin-like protein 1 [IPR039678]", "Beta-galactosidase 1-like [IPR026283]", "Beta-hexosaminidase [IPR025705]", "Beta-lactamase HcpB-like [IPR040239]", "Bicaudal-D protein [IPR018477]", "Bifunctional purine biosynthesis protein PurH-like [IPR002695]", "Biliverdin reductase A [IPR017094]", "Biotin--acetyl-CoA-carboxylase ligase [IPR004408]", "Brain acid soluble protein 1 [IPR008408]", "Bystin [IPR007955]", "C-5 cytosine methyltransferase [IPR001525]", "C-terminal binding protein [IPR043322]", "CAAX prenyl protease 1 [IPR027057]", "CCR4-NOT transcription complex subunit 1 [IPR040398]", "CCR4-NOT transcription complex subunit 7 [IPR039636]", "CCR4-NOT transcription complex subunit 7/8/Pop2 [IPR039637]", "CCR4-NOT transcription complex subunit 9 [IPR007216]", "CD2 antigen cytoplasmic tail-binding protein 2/Lin1 [IPR039905]", "CD2-associated protein [IPR028445]", "CD36 family [IPR002159]", "CD36/scavenger receptor class B member 1 [IPR005428]", "CDC45 family [IPR003874]", "CDGSH iron-sulfur domain-containing protein 1/2 [IPR045131]", "CDK5 regulatory subunit-associated protein 3 [IPR008491]", "CDP-alcohol phosphatidyltransferase [IPR000462]", "CDP-diacylglycerol-inositol 3-phosphatidyltransferase, eukaryote [IPR014387]", "CEBPZ/Mak21-like [IPR040155]", "CGG triplet repeat-binding protein 1 [IPR033375]", "CHORD domain containing protein [IPR039790]", "CLIP-associating protein 1 [IPR028399]", "CLU domain containing protein [IPR027523]", "COG complex component, COG2 [IPR009316]", "COMM domain-containing protein 4 [IPR037356]", "COMPASS component Swd2/WDR82 [IPR037867]", "COP9 Signalosome complex subunit 7A [IPR037757]", "COP9 signalosome complex subunit 1 [IPR033008]", "COP9 signalosome complex subunit 2 [IPR037750]", "COP9 signalosome complex subunit 3 [IPR037753]", "COP9 signalosome complex subunit 4 [IPR037754]", "COP9 signalosome complex subunit 5 [IPR037740]", "COP9 signalosome complex subunit 7B [IPR027530]", "COP9 signalosome subunit 6 [IPR033859]", "COP9 signalosome, subunit CSN8 [IPR033205]", "COPII coat assembly protein, Sec16 [IPR024880]", "COX15/CtaA family [IPR003780]", "CPSF6/7 family [IPR034772]", "CTP synthase [IPR004468]", "CWF11 family [IPR026300]", "CYFIP-related Rac1 interactor [IPR039789]", "Calcium homeostasis endoplasmic reticulum protein [IPR039037]", "Calcium load-activated calcium channel [IPR008559]", "Calcium uptake protein 1/2/3 [IPR039800]", "Calcium-binding mitochondrial carrier protein Aralar2 [IPR029658]", "Calcium-binding protein CAB45 [IPR027240]", "Caldesmon [IPR006017]", "Caldesmon/lymphocyte specific protein [IPR006018]", "Calpain small subunit 1 [IPR029642]", "Calpain-1 [IPR029643]", "Calpastatin [IPR026998]", "Calponin-2 [IPR029974]", "Calponin/LIMCH1 [IPR001997]", "Calreticulin [IPR009169]", "Calreticulin/calnexin [IPR001580]", "Calumenin [IPR027239]", "Caprin [IPR028816]", "Carbamoyl-phosphate synthase, large subunit [IPR006275]", "Carbamoyl-phosphate synthase, small subunit [IPR006274]", "Carbohydrate sulfotransferase 8-10 [IPR018011]", "Cartilage-associated protein [IPR033212]", "Casein Kinase 2, subunit alpha [IPR045216]", "Casein kinase II, regulatory subunit [IPR000704]", "Caspase-3/7 [IPR015471]", "Caspase-6 [IPR037554]", "Caspase-8 [IPR033170]", "Cat eye syndrome critical region protein 5 [IPR029621]", "Catechol O-methyltransferase, eukaryotic [IPR017128]", "Catenin delta-1 [IPR028439]", "Cation-dependent mannose-6-phosphate receptor [IPR000296]", "Cationic amino acid transport permease [IPR004755]", "Cdc37 [IPR004918]", "Cdc42 [IPR037874]", "Cdc73/Parafibromin [IPR007852]", "Cell cycle and apoptosis regulator protein 2 [IPR028811]", "Cell cycle and apoptosis regulator protein [IPR025224]", "Cell cycle checkpoint, Hus1 [IPR016580]", "Cell cycle regulator Mat89Bb [IPR019355]", "Cell division cycle protein 123 [IPR009772]", "Cell growth-regulating nucleolar protein [IPR039999]", "Cell-cycle alteration and expression-elevated protein in tumour [IPR032337]", "Centrin 2 [IPR037629]", "Centrosomal protein of 44kDa [IPR033603]", "Centrosomal protein of 55kDa [IPR038926]", "Ceroid-lipofuscinosis neuronal protein 5 [IPR026138]", "Cgr1-like [IPR005579]", "Chaperone DnaJ [IPR012724]", "Chaperone DnaK [IPR012725]", "Chaperone tailless complex polypeptide 1 (TCP-1) [IPR017998]", "Chaperonin Cpn60/GroEL [IPR001844]", "Chaperonin Cpn60/GroEL/TCP-1 family [IPR002423]", "Charged multivesicular body protein 1a [IPR029888]", "Checkpoint protein Hus1/Mec3 [IPR007150]", "Chitobiosyldiphosphodolichol beta-mannosyltransferase ALG1-like [IPR026051]", "Chloride channel CLIC-like [IPR009231]", "Chloride channel ClC-3 [IPR002245]", "Chloride channel, voltage gated [IPR001807]", "Chloride intracellular channel protein 1 [IPR030259]", "Chloride intracellular channel protein 4/6 [IPR030257]", "Chromatid cohesion factor MAU2 [IPR019440]", "Chromatin assembly factor 1 subunit Cac2/CHAF1B/FAS2 [IPR045145]", "Chromatin complexes subunit BAP18 [IPR037931]", "Chromatin modification-related protein Eaf6 [IPR015418]", "Chromobox protein homologue 3 [IPR038033]", "Chromosome alignment-maintaining phosphoprotein 1 [IPR039330]", "Cilia- and flagella-associated protein 20/CFAP20DC [IPR040441]", "Cip1-interacting zinc finger protein [IPR026811]", "Citrate synthase [IPR002020]", "Citrate synthase, eukaryotic-type [IPR010109]", "Class I-like SAM-dependent O-methyltransferase [IPR002935]", "Clathrin adaptor, mu subunit [IPR001392]", "Clathrin coat assembly protein AP180-like [IPR045192]", "Clathrin interactor 1 [IPR030544]", "Clathrin light chain [IPR000996]", "Clathrin, heavy chain [IPR016341]", "Cleavage and polyadenylation specificity factor subunit 2 [IPR027075]", "Cleavage and polyadenylation specificity factor subunit 6 [IPR034769]", "Cleavage and polyadenylation specificity factor subunit 7 [IPR034770]", "Cleavage stimulation factor subunit 1-like [IPR044633]", "Cleavage stimulation factor subunit 2 [IPR033105]", "Cleavage/polyadenylation specificity factor subunit 5 [IPR016706]", "Cleft lip and palate transmembrane 1 [IPR008429]", "Cleft lip and palate transmembrane protein 1-like protein [IPR030434]", "Clp protease proteolytic subunit /Translocation-enhancing protein TepA [IPR023562]", "Clp protease, ATP-binding subunit ClpX [IPR004487]", "ClpA/B family [IPR001270]", "Co-chaperone protein p23-like [IPR045250]", "Coactosin-like protein [IPR030502]", "Coatomer alpha subunit [IPR016391]", "Coatomer beta subunit (COPB1) [IPR016460]", "Coatomer beta' subunit (COPB2) [IPR016453]", "Coatomer delta subunit [IPR027059]", "Coatomer gamma subunit [IPR017106]", "Coatomer subunit zeta [IPR039652]", "Coatomer, epsilon subunit [IPR006822]", "Cobalamin-dependent methionine synthase [IPR011822]", "Cofilin 1 [IPR027234]", "Cohesin subunit Scc3/SA [IPR039662]", "Coiled-coil domain-containing protein 124/Oxs1 [IPR010422]", "Coiled-coil domain-containing protein 134 [IPR026321]", "Coiled-coil domain-containing protein 137 [IPR026680]", "Coiled-coil domain-containing protein 138 [IPR038798]", "Coiled-coil domain-containing protein 22 [IPR008530]", "Coiled-coil domain-containing protein 86 [IPR026570]", "Coiled-coil domain-containing protein 90-like [IPR024461]", "Coiled-coil domain-containing protein 93 [IPR039116]", "Coilin [IPR024822]", "Condensin complex subunit 2/barren [IPR022816]", "Condensin complex subunit 3 [IPR027165]", "Condensin subunit 1 [IPR007673]", "Condensin subunit 1/Condensin-2 complex subunit D3 [IPR026971]", "Conserved oligomeric Golgi complex subunit 6 [IPR010490]", "Constitutive coactivator of PPAR-gamma [IPR026784]", "Copine [IPR045052]", "Copper chaperone SCO1/SenC [IPR003782]", "Coproporphyrinogen III oxidase, aerobic [IPR001260]", "Core histone macro-H2A [IPR021171]", "Coronin 1B [IPR027340]", "Coronin 1C [IPR027333]", "Coronin [IPR015505]", "Cortactin [IPR015503]", "Csn12 family [IPR045114]", "Cullin [IPR045093]", "Cullin-4B [IPR033044]", "Cullin-associated NEDD8-dissociated protein 1/2 [IPR039852]", "Cwf19-like protein [IPR040194]", "Cyclic nucleotide phosphodiesterase [IPR008431]", "Cyclin [IPR039361]", "Cyclin-dependent kinase 6 [IPR028788]", "Cyclophilin-RNA interacting protein [IPR035542]", "Cyclophilin-type peptidyl-prolyl cis-trans isomerase [IPR024936]", "Cyclophilin-type peptidyl-prolyl cis-trans isomerase, cyclophilin A-like [IPR044666]", "Cysteine desulfurase IscS [IPR010240]", "Cysteine desulfurase [IPR016454]", "Cysteine-tRNA ligase [IPR015803]", "Cysteinyl-tRNA synthetase/mycothiol ligase [IPR024909]", "Cystinyl aminopeptidase [IPR034017]", "Cytochrome B561-related [IPR019176]", "Cytochrome P450 [IPR001128]", "Cytochrome P450, E-class, group I [IPR002401]", "Cytochrome P450, E-class, group IV [IPR002403]", "Cytochrome b-c1 complex subunit 7 [IPR003197]", "Cytochrome b-c1 complex subunit 8 [IPR004205]", "Cytochrome b-c1 complex subunit 9 [IPR008027]", "Cytochrome c oxidase assembly factor 3, mitochondrial [IPR041752]", "Cytochrome c oxidase subunit 6C [IPR004204]", "Cytochrome c oxidase subunit IV [IPR013288]", "Cytochrome c oxidase subunit IV family [IPR004203]", "Cytochrome c oxidase subunit VII [IPR039297]", "Cytochrome c oxidase subunit VIIa, metazoa [IPR003177]", "Cytochrome c oxidase subunit VIIc [IPR004202]", "Cytochrome c oxidase, subunit Va/VI [IPR003204]", "Cytochrome c oxidase, subunit Vb [IPR002124]", "Cytochrome c/quinol oxidase subunit II [IPR045187]", "Cytochrome c1 [IPR002326]", "Cytoplasmic FMR1-interacting [IPR008081]", "Cytoplasmic dynein 1 intermediate chain 1/2 [IPR025956]", "Cytoskeleton-associated protein 2 family [IPR026165]", "Cytoskeleton-associated protein 4 [IPR028428]", "Cytosolic Fe-S cluster assembly factor NUBP2/Cfd1, eukaryotes [IPR028600]", "Cytosolic acyl coenzyme A thioester hydrolase [IPR040170]", "Cytosolic nonspecific dipeptidase/DUG1 [IPR017153]", "Cytospin-A [IPR040166]", "D-3-phosphoglycerate dehydrogenase [IPR006236]", "DAD/Ost2 [IPR003038]", "DDRGK domain containing protein [IPR019153]", "DDX54/DBP10 family [IPR033517]", "DENR family, eukaryotes [IPR005873]", "DNA (cytosine-5)-methyltransferase 1-like [IPR017198]", "DNA damage-binding protein 1 [IPR031297]", "DNA double-strand break repair protein Mre11 [IPR003701]", "DNA fragmentation factor 45 [IPR017299]", "DNA helicase, ATP-dependent, RecQ type [IPR004589]", "DNA ligase, ATP-dependent [IPR000977]", "DNA mismatch repair Msh2-type [IPR011184]", "DNA mismatch repair MutS family [IPR045076]", "DNA mismatch repair protein Msh2 [IPR032642]", "DNA mismatch repair protein MutS/MSH [IPR017261]", "DNA polymerase V/Myb-binding protein 1A [IPR007015]", "DNA polymerase alpha, subunit B [IPR016722]", "DNA polymerase epsilon catalytic subunit [IPR029703]", "DNA primase large subunit, eukaryotic/archaeal [IPR007238]", "DNA primase, large subunit, eukaryotic [IPR016558]", "DNA primase, small subunit [IPR002755]", "DNA primase, small subunit, eukaryotic/archaeal [IPR014052]", "DNA repair protein Rad50, eukaryotes [IPR004584]", "DNA repair/transcription protein MET18/MMS19 [IPR039920]", "DNA replication complex GINS protein Psf2 [IPR007257]", "DNA replication licensing factor Mcm2 [IPR008045]", "DNA replication licensing factor Mcm3 [IPR008046]", "DNA replication licensing factor Mcm5 [IPR008048]", "DNA replication licensing factor Mcm6 [IPR008049]", "DNA replication licensing factor Mcm7 [IPR008050]", "DNA topoisomerase I [IPR001631]", "DNA topoisomerase II, eukaryotic-type [IPR001154]", "DNA topoisomerase II-beta [IPR028467]", "DNA topoisomerase, type IIA [IPR001241]", "DNA-directed DNA polymerase, family B [IPR006172]", "DNA-directed RNA pol I, largest subunit [IPR015699]", "DNA-directed RNA polymerase I, subunit RPA34.5 [IPR013240]", "DNA-directed RNA polymerase subunit RPABC5/Rpb10 [IPR000268]", "DNA-directed RNA polymerase subunit Rpo5/Rpb5 [IPR014381]", "DNA-directed RNA polymerase, phage-type [IPR002092]", "DNA-directed RNA polymerase, subunit 2 [IPR015712]", "DNA-directed RNA polymerase, subunit beta-prime [IPR045867]", "DNA-directed RNA polymerases I and III subunit AC40 [IPR033901]", "DNA2/NAM7-like helicase [IPR045055]", "Death-inducer obliterator 1 [IPR033082]", "Dedicator of cytokinesis [IPR026791]", "Defective-in-cullin neddylation protein [IPR014764]", "Delta l-pyrroline-5-carboxylate synthetase [IPR005766]", "Delta(24)-sterol reductase [IPR040165]", "Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase Ech1-like [IPR045002]", "Deoxycytidylate deaminase [IPR016473]", "Deoxycytidylate deaminase-related [IPR015517]", "Deoxyhypusine hydroxylase [IPR027517]", "Deoxyhypusine synthase [IPR002773]", "Deoxyuridine triphosphate nucleotidohydrolase [IPR008181]", "Dephospho-CoA kinase [IPR001977]", "Derlin [IPR007599]", "Dermcidin [IPR028130]", "Dermcidin/Lacritin [IPR043557]", "Desmoglein [IPR009123]", "Desmoplakin [IPR028462]", "Desmosomal cadherin [IPR009122]", "Destrin [IPR029924]", "Developmentally regulated GTP-binding protein [IPR045001]", "Dihydrofolate reductase [IPR012259]", "Dihydrolipoamide acetyltransferase/Pyruvate dehydrogenase protein X component [IPR045257]", "Dihydrolipoamide dehydrogenase [IPR006258]", "Dihydrolipoamide succinyltransferase [IPR006255]", "Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex [IPR006257]", "Dihydropyrimidinase-related protein 1 [IPR030624]", "Dihydropyrimidinase-related protein 2 [IPR030615]", "Dihydropyrimidinase-related protein 3 [IPR030628]", "Dihydroxyacetone kinase [IPR012734]", "Dimethylarginine dimethylaminohydrolase [IPR033199]", "Dipeptidyl-peptidase 3 [IPR005317]", "Diphthamide synthesis DHP2 [IPR010014]", "Diphthamide synthesis DPH1/DPH2 [IPR016435]", "Diphthine synthase [IPR004551]", "Divalent ion tolerance protein, CutA [IPR004323]", "DnaJ homolog subfamily A member 1/2-like [IPR044713]", "DnaJ homolog subfamily C member 8 [IPR042858]", "DnaJ homologue subfamily C member 10 [IPR021170]", "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48kDa subunit [IPR005013]", "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit Swp1 [IPR008814]", "Dolichyldiphosphatase 1 [IPR039666]", "Drebrin [IPR028438]", "Drebrin-like protein [IPR029923]", "Dynactin subunit 3 [IPR009991]", "Dynactin subunit 4 [IPR008603]", "Dynactin subunit 6 [IPR027777]", "Dynamin [IPR022812]", "Dynamin-1-like protein [IPR030556]", "Dynamin-2 [IPR027188]", "Dynamin-like 120kDa protein, mitochondrial [IPR033047]", "Dynamitin [IPR028133]", "Dynein 1 light intermediate chain [IPR008467]", "Dynein family light intermediate chain [IPR022780]", "Dynein light chain, type 1/2 [IPR001372]", "Dynein regulator LIS1 [IPR017252]", "Dyslexia-associated protein KIAA0319-like [IPR029865]", "Dystrophin/utrophin [IPR035436]", "E3 UFM1-protein ligase 1 [IPR018611]", "E3 ubiquitin ligase Bre1 [IPR013956]", "E3 ubiquitin ligase RBR family [IPR031127]", "E3 ubiquitin ligase UBR4-like [IPR045189]", "E3 ubiquitin-protein ligase CHIP/LubX [IPR045200]", "E3 ubiquitin-protein ligase HECTD1/TRIP12-like [IPR045322]", "E3 ubiquitin-protein ligase RBBP6 family [IPR033489]", "E3 ubiquitin-protein ligase RNF14 [IPR031128]", "E3 ubiquitin-protein ligase, SMURF1 type [IPR024928]", "EB1, Metazoa [IPR027739]", "EB2, vertebrate [IPR027735]", "ECSIT [IPR010418]", "EH domain-containing protein 1/3 [IPR029951]", "EH domain-containing protein 4 [IPR029952]", "ELL/occludin family [IPR031176]", "ELP3/YhcC [IPR039661]", "ER lumen protein retaining receptor [IPR000133]", "ER membrane protein complex subunit 1 [IPR026895]", "ER membrane protein complex subunit 2-like [IPR039856]", "ER membrane protein complex subunit 3 [IPR008568]", "ERG2/sigma1 receptor-like [IPR006716]", "ERp19 [IPR037462]", "Ecd family [IPR010770]", "Electron transfer flavoprotein alpha subunit/FixB [IPR001308]", "Electron transfer flavoprotein, beta subunit [IPR012255]", "Electron transfer flavoprotein-ubiquinone oxidoreductase [IPR040156]", "Elongation factor G1-like [IPR045044]", "Elongator complex protein 1 [IPR006849]", "Elongator complex protein 2 [IPR037289]", "Elongator complex protein 3-like [IPR034687]", "Elongin B [IPR039049]", "Elongin-C [IPR039948]", "Emerin [IPR035004]", "Emopamil-binding protein [IPR007905]", "Endonuclease domain-containing 1 protein [IPR039015]", "Endophilin-A [IPR028501]", "Endophilin-B1 [IPR028503]", "Endoplasmic reticulum aninopeptidase 1 [IPR033520]", "Endoplasmic reticulum oxidoreductin 1 [IPR007266]", "Endoplasmic reticulum protein SC65 [IPR033213]", "Endoplasmic reticulum resident protein 29 [IPR016855]", "Endoplasmic reticulum vesicle transporter [IPR045888]", "Endosulphine [IPR006760]", "Endothelin-converting enzyme 1 [IPR029734]", "Enhancer of mRNA-decapping protein 4-like [IPR045152]", "Enhancer of rudimentary [IPR000781]", "Enolase [IPR000941]", "Enoyl-CoA hydratase/isomerase [IPR001753]", "Enoyl-CoA hydratase/isomerase, HIBYL-CoA-H type [IPR032259]", "Epoxide hydrolase [IPR016292]", "Epoxide hydrolase-like [IPR000639]", "Equilibrative nucleoside transporter 1 [IPR030195]", "Equilibrative nucleoside transporter [IPR002259]", "Ergosterol biosynthesis ERG4/ERG24 [IPR001171]", "Erlin1/2 [IPR033294]", "Esterase-like [IPR000801]", "Eukaryotic porin/Tom40 [IPR027246]", "Eukaryotic rRNA processing [IPR008610]", "Eukaryotic translation elongation factor 1 epsilon-1 [IPR042450]", "Eukaryotic translation initiation factor 2D [IPR039757]", "Eukaryotic translation initiation factor 3 subunit A [IPR027512]", "Eukaryotic translation initiation factor 3 subunit B [IPR011400]", "Eukaryotic translation initiation factor 3 subunit D [IPR007783]", "Eukaryotic translation initiation factor 3 subunit E [IPR016650]", "Eukaryotic translation initiation factor 3 subunit F [IPR027531]", "Eukaryotic translation initiation factor 3 subunit G [IPR017334]", "Eukaryotic translation initiation factor 3 subunit H [IPR027524]", "Eukaryotic translation initiation factor 3 subunit I [IPR027525]", "Eukaryotic translation initiation factor 3 subunit J [IPR013906]", "Eukaryotic translation initiation factor 3 subunit K [IPR009374]", "Eukaryotic translation initiation factor 3 subunit M [IPR027528]", "Eukaryotic translation initiation factor 3 subunit M eIF3m/COP9 signalosome complex subunit 7 COPS7 [IPR045237]", "Eukaryotic translation initiation factor 4 gamma 1 [IPR037584]", "Eukaryotic translation initiation factor 4 gamma 3 [IPR037585]", "Eukaryotic translation initiation factor 4B [IPR033107]", "Exocyst complex component EXOC2/Sec5 [IPR029175]", "Exocyst complex component EXOC5/Sec10 [IPR033960]", "Exocyst complex component Exo70 [IPR004140]", "Exocyst complex component Sec10-like [IPR009976]", "Exocyst complex component Sec8/EXOC4 [IPR039682]", "Exonuclease 1 [IPR032641]", "Exosome complex RNA-binding protein 1/RRP40/RRP4 [IPR026699]", "Exosome complex component Rrp43 [IPR033196]", "Exosome complex exonuclease Rrp6-like [IPR045092]", "Exportin 4/7-like [IPR044189]", "Exportin-1/5 [IPR045065]", "Exportin-5 [IPR040018]", "Exportin-7 [IPR040021]", "Exportin-T [IPR040017]", "Ezrin/radixin/moesin [IPR011174]", "Ezrin/radixin/moesin-like [IPR000798]", "F-actin-capping protein subunit alpha [IPR002189]", "F-actin-capping protein subunit beta [IPR001698]", "FACT complex subunit Spt16 [IPR040258]", "FAD synthetase with the MoaB/Mog domain [IPR012183]", "FAD-dependent glycerol-3-phosphate dehydrogenase [IPR000447]", "FAD-dependent oxidoreductase SdhA/FrdA/AprA [IPR030664]", "FAM3 family [IPR039220]", "FAM91 [IPR039199]", "FAM98 [IPR018797]", "FH1/FH2 domain-containing protein 1 [IPR027647]", "FUN14 [IPR007014]", "Fanconi anemia group I protein [IPR026171]", "Fascin [IPR010431]", "Fascin, metazoans [IPR024703]", "Fascin-1 [IPR030146]", "Fatty acid desaturase [IPR012171]", "Fatty acid oxidation complex, alpha subunit, mitochondrial [IPR012803]", "Fatty acid transport protein 4 [IPR030304]", "Fatty acyl-CoA reductase [IPR026055]", "Fcf2/DNTTIP2 [IPR039883]", "Ferredoxin-NADP+ reductase, adrenodoxin-type [IPR021163]", "Ferrochelatase [IPR001015]", "Fibrillarin [IPR000692]", "Filamin family [IPR044801]", "Filamin-B [IPR029874]", "Fimbrin/Plastin [IPR039959]", "Flagellum site-determining protein YlxH/ Fe-S cluster assembling factor NBP35 [IPR033756]", "Flap endonuclease 1 [IPR023426]", "Flotillin family [IPR027705]", "Forkhead box protein C1 [IPR033067]", "Formate-tetrahydrofolate ligase, FTHFS [IPR000559]", "Formin, protein diaphanous homologue 1 [IPR027653]", "Formin, protein diaphanous homologue 3 [IPR027654]", "Four and a half LIM domains protein 1 [IPR042997]", "Fragile X mental retardation syndrome-related protein [IPR040148]", "Fructosamine/Ketosamine-3-kinase [IPR016477]", "Fructose-bisphosphate aldolase, class-I [IPR000741]", "Fumarate hydratase, class II [IPR005677]", "Fumarate lyase family [IPR000362]", "Fumarylacetoacetase [IPR005959]", "G-protein alpha subunit, group 12/13 [IPR000469]", "G-protein alpha subunit, group I [IPR001408]", "G-rich sequence factor 1 [IPR033106]", "G10 protein [IPR001748]", "GDP dissociation inhibitor [IPR018203]", "GDP-fucose protein O-fucosyltransferase 1 [IPR039922]", "GDP-fucose protein O-fucosyltransferase [IPR019378]", "GDP-mannose 4,6-dehydratase [IPR006368]", "GH3 family [IPR004993]", "GINS complex subunit Sld5 [IPR008591]", "GINS complex, subunit Psf3 [IPR010492]", "GPI-anchor transamidase [IPR028361]", "GRASP55/65 [IPR007583]", "GRIM-19 [IPR009346]", "GTP-binding protein 1 [IPR039263]", "GTP-binding protein Era [IPR005662]", "GTP-binding protein Obg/CgtA [IPR014100]", "GTP-binding protein Rheb [IPR037586]", "Galactokinase [IPR000705]", "Galectin-3 [IPR015534]", "Galectin-like [IPR044156]", "Gamma-adducin [IPR027772]", "Gamma-glutamylcyclotransferase [IPR017939]", "Gamma-tubulin complex component protein [IPR007259]", "Ganglioside GM2 activator [IPR028996]", "Ganglioside-induced differentiation-associated protein 1 [IPR034336]", "Gdt1 family [IPR001727]", "Gem-associated protein 4 [IPR033265]", "Glia maturation factor [IPR011171]", "Glomulin/ALF4 [IPR019516]", "Glu-tRNAGln amidotransferase C subunit [IPR003837]", "Glucosamine-6-phosphate isomerase [IPR004547]", "Glucosamine-fructose-6-phosphate aminotransferase, isomerising [IPR005855]", "Glucose transporter GLUT [IPR045263]", "Glucose transporter, type 1 (GLUT1) [IPR002439]", "Glucose-6-phosphate dehydrogenase [IPR001282]", "Glucosidase II beta subunit-like [IPR039794]", "Glutamate 5-kinase/delta-1-pyrroline-5-carboxylate synthase [IPR005715]", "Glutamate carboxypeptidase 2-like [IPR039373]", "Glutamate--cysteine ligase regulatory subunit [IPR032963]", "Glutamate-tRNA ligase, bacterial/mitochondrial [IPR004527]", "Glutamate/acetylglutamate kinase [IPR001057]", "Glutamate/phenylalanine/leucine/valine dehydrogenase [IPR006095]", "Glutaminase [IPR015868]", "Glutamine-tRNA synthetase [IPR004514]", "Glutamyl-tRNA synthetase, archaeal/eukaryotic cytosolic [IPR004526]", "Glutamyl-tRNA(Gln) amidotransferase A subunit [IPR004412]", "Glutamyl/glutaminyl-tRNA synthetase [IPR000924]", "Glutathione S-transferase Omega/Tau-like [IPR045073]", "Glutathione S-transferase kappa [IPR044088]", "Glutathione S-transferase, Mu class [IPR003081]", "Glutathione S-transferase, omega-class [IPR005442]", "Glutathione S-transferases, class Zeta [IPR005955]", "Glutathione Transferase family [IPR040079]", "Glutathione peroxidase Gpx7, putative [IPR013376]", "Glutathione peroxidase [IPR000889]", "Glutathione reductase, eukaryote/bacterial [IPR006322]", "Glutathione synthase [IPR005615]", "Glutathione-specific gamma-glutamylcyclotransferase [IPR006840]", "Glyceraldehyde-3-phosphate dehydrogenase, type I [IPR006424]", "Glyceraldehyde/Erythrose phosphate dehydrogenase family [IPR020831]", "Glycerol-3-phosphate O-acyltransferase/Dihydroxyacetone phosphate acyltransferase [IPR022284]", "Glycerol-3-phosphate acyltransferase, PlsB [IPR028354]", "Glycine cleavage system P protein [IPR020581]", "Glycine dehydrogenase (decarboxylating) [IPR003437]", "Glycogen debranching enzyme [IPR010401]", "Glycogen debranching enzyme, metazoa [IPR006421]", "Glycogen synthase kinase-3 beta [IPR033573]", "Glycogen/starch/alpha-glucan phosphorylase [IPR011833]", "Glycoside hydrolase family 30 [IPR001139]", "Glycoside hydrolase family 31 [IPR000322]", "Glycoside hydrolase family 63 [IPR004888]", "Glycoside hydrolase, family 2 [IPR006101]", "Glycoside hydrolase, family 27 [IPR002241]", "Glycoside hydrolase, family 29 [IPR000933]", "Glycoside hydrolase, family 35 [IPR001944]", "Glycosyl transferase, family 25 [IPR002654]", "Glycosyl transferase, family 31 [IPR002659]", "Glycosyl transferase, family 35 [IPR000811]", "Glycosyl transferase, family 8 [IPR002495]", "Glycyl-tRNA synthetase [IPR002315]", "Glycyl-tRNA synthetase/DNA polymerase subunit gamma-2 [IPR027031]", "Glyoxalase I [IPR004361]", "Glyoxalase domain-containing protein 4 [IPR043193]", "Golgi apparatus protein 1 [IPR039728]", "Golgi integral membrane protein 4 [IPR042336]", "Golgi phosphoprotein 3-like [IPR008628]", "Golgi to ER traffic protein 4 [IPR007317]", "Golgin subfamily A member 3 [IPR033288]", "Golgin subfamily B member 1 [IPR026202]", "Graves disease carrier protein [IPR002167]", "GroES chaperonin family [IPR020818]", "Growth arrest/ DNA-damage-inducible protein-interacting protein 1 [IPR018472]", "GrpE nucleotide exchange factor [IPR000740]", "Guanine nucleotide binding protein (G-protein), alpha subunit [IPR001019]", "Guanine nucleotide exchange factor, Ric8 [IPR019318]", "Guanine nucleotide-exchange factor Sec12-like [IPR045260]", "H/ACA ribonucleoprotein complex non-core subunit Naf1 [IPR040309]", "H/ACA ribonucleoprotein complex, subunit Gar1/Naf1 [IPR007504]", "H/ACA ribonucleoprotein complex, subunit Nhp2, eukaryote [IPR002415]", "H/ACA ribonucleoprotein complex, subunit Nop10 [IPR007264]", "HAD hydrolase, LHPP/HDHD2 [IPR006355]", "HAD hydrolase, subfamily IA [IPR006439]", "HAD-superfamily hydrolase, subfamily IA, REG-2-like [IPR011949]", "HAD-superfamily hydrolase, subfamily IG, 5'-nucleotidase [IPR008380]", "HAD-superfamily hydrolase, subfamily IIA [IPR006357]", "HAD-superfamily hydrolase, subfamily IIA, CECR5 [IPR006353]", "HAUS augmin-like complex subunit 4 [IPR029327]", "HAUS augmin-like complex subunit 4, metazoa [IPR026214]", "HAUS augmin-like complex subunit 5 [IPR029131]", "HAUS complex subunit 5, metazoa [IPR026215]", "HCCA isomerase/glutathione S-transferase kappa [IPR014440]", "HMG-CoA lyase [IPR043594]", "Haem oxygenase [IPR002051]", "Haem oxygenase-like [IPR016053]", "Haloacid dehalogenase-like hydrolase [IPR041492]", "Ham1-like protein [IPR002637]", "Heat shock protein 70 family [IPR013126]", "Heat shock protein Hsp90 family [IPR001404]", "Heat shock protein Sti1-like [IPR045248]", "Helicase MOV-10 [IPR026122]", "Helicase XPB/Ssl2 [IPR001161]", "Helicase superfamily 1/2, DinG/Rad3-like [IPR045028]", "Heme A synthase, type 2 [IPR023754]", "Heparan sulphate 2-O-sulfotransferase [IPR007734]", "Heterochromatin protein 1-binding protein 3 [IPR033061]", "Heterogeneous nuclear ribonucleoprotein C [IPR017347]", "Heterogeneous nuclear ribonucleoprotein K [IPR033090]", "Heterogeneous nuclear ribonucleoprotein M [IPR024667]", "Heterogeneous nuclear ribonucleoprotein U [IPR026745]", "Heterogeneous nuclear ribonucleoprotein U-like protein 1 [IPR027025]", "Hexokinase [IPR001312]", "High mobility group protein HMG-I/HMG-Y, chordates [IPR031079]", "High mobility group protein HMGA [IPR000116]", "High mobility group protein HMGB1 [IPR031076]", "High mobility group protein HMGB3 [IPR031077]", "Histidine acid phosphatase, eukaryotic [IPR016274]", "Histidine phosphatase superfamily, clade-1 [IPR013078]", "Histidine phosphatase superfamily, clade-2 [IPR000560]", "Histidine triad (HIT) protein [IPR001310]", "Histone H2A [IPR002119]", "Histone H4 [IPR001951]", "Histone acetyltransferase type B, catalytic subunit [IPR017380]", "Histone chaperone ASF1-like [IPR006818]", "Histone deacetylase [IPR003084]", "Histone deacetylase complex subunit SAP130 [IPR024137]", "Histone deacetylase complex, SAP18 subunit [IPR017250]", "Histone deacetylase family [IPR000286]", "Histone demethylase JHDM2-like [IPR045109]", "Histone lysine-specific demethylase [IPR017366]", "Histone-lysine N-methyltransferase SETD2, animal [IPR042294]", "Histone-lysine N-methyltransferase Smyd3 [IPR025805]", "HnRNP R/Q splicing factor [IPR006535]", "HnRNP-L/PTB [IPR006536]", "Holocytochrome c/c1 synthase [IPR000511]", "Host cell factor 1 [IPR037854]", "Host cell factor [IPR043536]", "Huntingtin [IPR000091]", "Huntingtin family [IPR028426]", "Hydantoinase/dihydropyrimidinase [IPR011778]", "Hydroxymethylglutaryl-CoA synthase, eukaryotic [IPR010122]", "Hypoxanthine phosphoribosyl transferase [IPR005904]", "I-BAR domain containing protein IRSp53 [IPR030128]", "I-BAR domain containing protein IRSp53/IRTKS/Pinkbar [IPR027681]", "ICln [IPR003521]", "Immunity-related GTPase family Q protein [IPR040070]", "Importin beta family [IPR040122]", "Importin subunit alpha [IPR024931]", "Inhibitor of nuclear factor kappa-B kinase-interacting protein [IPR024152]", "Initiation factor 2B-related [IPR000649]", "Initiation factor 4G [IPR045208]", "Inner nuclear membrane protein Man1 [IPR034997]", "Inorganic pyrophosphatase [IPR008162]", "Inosine triphosphate pyrophosphatase [IPR027502]", "Inosine-5'-monophosphate dehydrogenase [IPR005990]", "Inositol monophosphatase-like [IPR000760]", "Insulin receptor substrate [IPR039011]", "Insulin-like growth factor 2 mRNA-binding protein 2 [IPR028743]", "Integral membrane protein EMC3/TMCO1-like [IPR002809]", "Integrator complex subunit 14 [IPR039841]", "Integrator complex subunit 3 [IPR045334]", "Integrator complex subunit 7 [IPR033060]", "Integrin beta subunit [IPR015812]", "Integrin beta-1 subunit [IPR027071]", "Interferon-induced protein with tetratricopeptide repeat 5 [IPR024125]", "Interferon-inducible double-stranded RNA-dependent protein kinase activator A [IPR033363]", "Interleukin enhancer-binding factor 3 [IPR033099]", "Intracellular chloride channel [IPR002946]", "Intracellular lipid binding protein [IPR031259]", "Intraflagellar transport protein 27 homologue, eukaryotes [IPR034112]", "Inverted formin-2 [IPR027649]", "Iron regulatory protein 1 [IPR029784]", "Iron-sulfur protein NUBPL-like [IPR044304]", "Isocitrate dehydrogenase NAD-dependent [IPR004434]", "Isocitrate dehydrogenase NADP-dependent [IPR004790]", "Isoleucine-tRNA ligase [IPR002301]", "Isoleucine-tRNA ligase, type 1 [IPR023585]", "Isoleucine-tRNA ligase, type 2 [IPR023586]", "Isopentenyl-diphosphate delta-isomerase, type 1 [IPR011876]", "Isoprenylcysteine carboxyl methyltransferase [IPR007269]", "Isovaleryl-CoA dehydrogenase [IPR034183]", "J-protein Zuotin/DnaJC2 [IPR044634]", "JNK-interacting protein 3/4 [IPR039911]", "JmjC domain-containing [IPR039994]", "Junction plakoglobin [IPR030461]", "Junctional adhesion molecule A [IPR042456]", "KH domain-containing BBP-like [IPR045071]", "KIF-1 binding protein [IPR022083]", "KRR1 interacting protein 1 [IPR018034]", "Kae1/TsaD family [IPR017861]", "Keratin, type I [IPR002957]", "Kindlin/fermitin [IPR037843]", "Kinectin [IPR024854]", "Kinesin light chain [IPR002151]", "Kinesin-like protein KIF20A [IPR027326]", "Kinesin-like protein KIF22 (Kid) [IPR026986]", "Kinesin-like protein [IPR027640]", "Kinetochore protein Spc25 [IPR045143]", "Kinetochore-Ndc80 subunit Spc24 [IPR013252]", "Ku70 [IPR006165]", "Ku80 [IPR024193]", "Kynurenine--oxoglutarate transaminase 3 [IPR034612]", "L-lactate dehydrogenase [IPR011304]", "L-lactate/malate dehydrogenase [IPR001557]", "LAMTOR1/MEH1 [IPR028209]", "LAR-interacting protein, Liprin [IPR029515]", "LEM domain-containing protein 2 [IPR034994]", "LETM1/MDM38-like [IPR044202]", "LIM domain and actin-binding protein 1 [IPR028740]", "LIM domain and actin-binding protein LIMA-like [IPR045268]", "LRP chaperone MESD [IPR019330]", "La domain containing protein [IPR045180]", "Las1 [IPR007174]", "Lecithin:cholesterol/phospholipid:diacylglycerol acyltransferase [IPR003386]", "Lethal(2) giant larvae protein [IPR000664]", "Leucine zipper transcription factor-like protein 1 [IPR026157]", "Leucine-rich PPR motif-containing protein [IPR033490]", "Leucine-rich repeat protein SHOC2 [IPR027036]", "Leucine-tRNA ligase [IPR002302]", "Leucyl-tRNA synthetase, class Ia, archaeal/eukaryotic cytosolic [IPR004493]", "Leukocyte surface antigen CD47 [IPR006704]", "Leukotriene A4 hydrolase/leucine aminopeptidase [IPR012777]", "Leukotriene B4 12-hydroxydehydrogenase/15-oxo-prostaglandin 13-reductase [IPR014190]", "Like-Sm (LSM) domain containing protein, LSm4/SmD1/SmD3 [IPR027141]", "Linker histone H1/H5 [IPR005819]", "Lipase, eukaryotic [IPR025483]", "Lipoma-preferred partner [IPR028771]", "Liprin-alpha-1 [IPR030438]", "Lon protease [IPR027065]", "Lon protease homologue, chloroplastic/mitochondrial [IPR027503]", "Lon protease, bacterial/eukaryotic-type [IPR004815]", "Long-chain fatty acid CoA synthetase, eukaryotic [IPR045311]", "Low temperature viability protein Ltv1 [IPR007307]", "Luc7-related [IPR004882]", "Lunapark family [IPR040115]", "Lupus La protein [IPR002344]", "Lysine-tRNA ligase, class II [IPR002313]", "Lysophosphatidylserine lipase ABHD12 [IPR026605]", "Lysosomal thioesterase PPT2 [IPR030295]", "Lysosome membrane protein II [IPR005429]", "Lysosome-associated membrane glycoprotein [IPR002000]", "MCT-1/Tma20 [IPR016437]", "MCU family [IPR039055]", "MDN2-binding protein [IPR039061]", "MICOS complex subunit MIC19/MIC25 [IPR007964]", "MICOS complex subunit MIC26/MIC27 [IPR019166]", "MICOS complex subunit MIC26/MIC27, animal [IPR033182]", "MICOS complex subunit Mic13 [IPR026769]", "MIOS/Sea4 [IPR037593]", "MRG [IPR008676]", "MRPS27/PTCD2 [IPR034913]", "Macrophage migration inhibitory factor [IPR001398]", "Mad2-like [IPR045091]", "Magnesium transporter protein 1 [IPR006844]", "Major facilitator superfamily [IPR011701]", "Major facilitator, sugar transporter-like [IPR005828]", "Mak16 protein [IPR006958]", "Malate dehydrogenase, NAD-dependent, cytosolic [IPR011274]", "Malate dehydrogenase, type 1 [IPR010097]", "Malate dehydrogenase, type 2 [IPR010945]", "Malectin [IPR039155]", "Malic oxidoreductase [IPR001891]", "Manganese/iron superoxide dismutase [IPR001189]", "Mannose-6-phosphate isomerase [IPR016305]", "Mannose-6-phosphate isomerase, type I [IPR001250]", "Mannose-6-phosphate receptor [IPR028927]", "Mannose-P-dolichol utilization defect 1 protein [IPR016817]", "Matrix-remodeling-associated protein 7 [IPR026622]", "Mediator complex, subunit Med24, [IPR021429]", "Medium-chain dehydrogenase/reductase [IPR045010]", "Medium-chain specific acyl-CoA dehydrogenase [IPR034180]", "Melanoma-associated antigen D2 [IPR028810]", "Melanoma-associated antigen [IPR037445]", "Membrane insertase YidC/ALB3/OXA1/COX18 [IPR001708]", "Membrane bound O-acyl transferase, MBOAT [IPR004299]", "Membrane-associated, eicosanoid/glutathione metabolism (MAPEG) protein [IPR001129]", "Mesoderm induction early response protein/metastasis-associated protein [IPR040138]", "Metal-dependent protein hydrolase [IPR003226]", "Metastasis-associated protein MTA2 [IPR037964]", "Methionine-tRNA ligase, type 1 [IPR023458]", "Methionine-tRNA synthetase, type 2 [IPR023457]", "Methionyl-tRNA synthetase [IPR014758]", "Methyl-CpG binding protein MeCP2 [IPR017353]", "Methyl-CpG binding protein MeCP2/MBD4 [IPR045138]", "Methylcrotonoyl-CoA carboxylase beta chain MCCB/AccD1-like [IPR045190]", "Methylmalonate-semialdehyde dehydrogenase [IPR010061]", "Methylthioadenosine phosphorylase (MTAP) [IPR010044]", "Mevalonate/galactokinase [IPR006206]", "Microfibrillar-associated protein 1 [IPR033194]", "Microtubule associated protein 1 [IPR026074]", "Microtubule-associated protein 1B [IPR027321]", "Microtubule-associated protein 1S [IPR027322]", "Microtubule-associated protein 4 [IPR027323]", "Microtubule-associated protein Jupiter [IPR033335]", "Microtubule-associated protein RP/EB [IPR027328]", "Microtubule-associated protein, MAP65/Ase1/PRC1 [IPR007145]", "Midasin [IPR012099]", "Midline-1 [IPR027727]", "Mini-chromosome maintenance complex protein 4 [IPR008047]", "Mini-chromosome maintenance complex-binding protein [IPR019140]", "Mini-chromosome maintenance protein [IPR031327]", "Mitochondria fission 1 protein [IPR016543]", "Mitochondrial 18kDa protein [IPR019560]", "Mitochondrial 28S ribosomal protein S31 [IPR026299]", "Mitochondrial 28S ribosomal protein S34 [IPR032053]", "Mitochondrial ATP synthase subunit g, animal [IPR016702]", "Mitochondrial ATPase inhibitor [IPR007648]", "Mitochondrial Rho GTPase 1 [IPR029506]", "Mitochondrial Rho GTPase [IPR021181]", "Mitochondrial antiviral-signalling protein, metazoan [IPR026148]", "Mitochondrial calcium uniporter regulator 1 [IPR012439]", "Mitochondrial carrier UCP-like [IPR002030]", "Mitochondrial carrier protein [IPR002067]", "Mitochondrial glycoprotein [IPR003428]", "Mitochondrial import inner membrane translocase subunit Tim10 [IPR027100]", "Mitochondrial import inner membrane translocase subunit Tim44 [IPR017303]", "Mitochondrial import inner membrane translocase subunit Tim50 [IPR027111]", "Mitochondrial import inner membrane translocase subunit Tim8/13 [IPR039238]", "Mitochondrial import receptor subunit TOM5, metazoa [IPR029179]", "Mitochondrial import receptor subunit Tom22 [IPR005683]", "Mitochondrial inner membrane protein Mitofilin [IPR019133]", "Mitochondrial inner membrane translocase complex, subunit Tim17 [IPR005678]", "Mitochondrial inner membrane translocase complex, subunit Tim23 [IPR005681]", "Mitochondrial outer membrane translocase complex, subunit Tom5 [IPR019603]", "Mitochondrial phosphate carrier protein Pic2/Mir1-like [IPR044677]", "Mitochondrial processing peptidase subunit beta [IPR037718]", "Mitochondrial ribosomal protein L48 [IPR027487]", "Mitochondrial-processing peptidase subunit alpha [IPR037715]", "Mitofusin family [IPR027094]", "Mitofusin-1 [IPR027088]", "Mitofusin-2 [IPR027089]", "Mitogen-activated protein (MAP) kinase p38-like [IPR008352]", "Mitogen-activated protein (MAP) kinase phosphatase [IPR008343]", "Mitogen-activated protein (MAP) kinase, ERK1/2 [IPR008349]", "Mitogen-activated protein kinase 14 [IPR038784]", "Mitoguardin [IPR019392]", "Mitotic spindle checkpoint protein Bub1/Mad3 [IPR015661]", "Molecular chaperone regulator BAG [IPR039773]", "Molybdate-anion transporter [IPR008509]", "Molybdate-anion transporter, animal type [IPR030163]", "Molybdopterin biosynthesis protein MoeA-like [IPR038987]", "Monocarboxylate transporter 1 [IPR030757]", "Monocarboxylate transporter [IPR004743]", "Monothiol glutaredoxin-related [IPR004480]", "Mortality factor 4-like protein 1 [IPR038011]", "Mpv17/PMP22 [IPR007248]", "Mrp/NBP35 ATP-binding protein [IPR019591]", "Multidrug resistance protein 1 [IPR030258]", "Multiple myeloma tumor-associated protein 2-like [IPR039207]", "Myelin expression factor 2 [IPR034632]", "Myeloid-derived growth factor [IPR018887]", "Myo-inositol-1-phosphate synthase [IPR002587]", "Myristoyl-CoA:protein N-myristoyltransferase [IPR000903]", "Myristoylated alanine-rich C-kinase substrate MARCKS [IPR002101]", "N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 [IPR033197]", "N-acetyl-D-glucosamine kinase NAGK-like [IPR039758]", "N-acetylglucosamine-6-sulfatase [IPR012251]", "N-acetylglucosamine-6-sulfatase, metazoan [IPR015981]", "N-acetyltransferase Ard1-like [IPR045047]", "N-acetyltransferase B complex, non-catalytic subunit [IPR019183]", "N-alpha-acetyltransferase 40 [IPR039949]", "N-end rule aminoacyl transferase [IPR030700]", "N-terminal acetyltransferase A, auxiliary subunit [IPR021183]", "NAD kinase 2, mitochondrial [IPR012355]", "NAD kinase [IPR002504]", "NAD(P) transhydrogenase, alpha subunit [IPR026255]", "NAD(P)H-quinone oxidoreductase subunit D/H [IPR022885]", "NAD/FAD transporter SLC25A32-like [IPR044712]", "NADH dehydrogenase, subunit C [IPR010218]", "NADH ubiquinone oxidoreductase, F subunit [IPR011537]", "NADH-quinone oxidoreductase subunit E-like [IPR002023]", "NADH-quinone oxidoreductase, chain I [IPR010226]", "NADH-ubiquinone oxidoreductase, 20 Kd subunit [IPR006138]", "NADH-ubiquinone oxidoreductase, subunit 10 [IPR019377]", "NADH-ubiquinone reductase complex 1 MLRQ subunit [IPR010530]", "NADH:cytochrome b5 reductase-like [IPR001834]", "NADH:ubiquinone oxidoreductase, ESSS subunit [IPR019329]", "NADH:ubiquinone oxidoreductase, NDUFB5/SGDH subunit [IPR019173]", "NADH:ubiquinone oxidoreductase, subunit G [IPR010228]", "NADH:ubiquinone oxidoreductase, subunit NDUFB4 [IPR009866]", "NADPH-cytochrome P450 reductase [IPR023208]", "NDRG [IPR004142]", "NEDD8 ultimate buster 1 [IPR039749]", "NEDD8-activating enzyme E1 catalytic subunit [IPR030468]", "NEDD8-activating enzyme E1 regulatory subunit APP-BP1 [IPR030667]", "NF-kappa-B/Dorsal [IPR000451]", "NOL6/Upt22 [IPR005554]", "NPC1-like [IPR004765]", "NSF attachment protein [IPR000744]", "Na(+)/H(+) exchange regulatory cofactor NHERF-1 [IPR031199]", "Na(+)/H(+) exchange regulatory cofactor NHERF-1/2 [IPR017300]", "Nck-associated protein 1 [IPR019137]", "Negative elongation factor E [IPR033102]", "Nesprin-2 [IPR030266]", "Nestin [IPR031211]", "Neurochondrin [IPR008709]", "Neurofilament light polypeptide [IPR027692]", "Neurofilament medium polypeptide [IPR027697]", "Nibrin [IPR016592]", "Nibrin-related [IPR040227]", "Nicalin [IPR016574]", "Nicastrin [IPR008710]", "Nicotinamide phosphoribosyl transferase [IPR016471]", "Nitric oxide synthase-interacting protein [IPR016818]", "Nonaspanin (TM9SF) [IPR004240]", "Nuclear RNA export factor [IPR030217]", "Nuclear cap-binding protein subunit 1 [IPR027159]", "Nuclear cap-binding protein subunit 2 [IPR027157]", "Nuclear factor NF-kappa-B, p105 subunit [IPR030503]", "Nuclear factor hnRNPA1 [IPR021662]", "Nuclear fragile X mental retardation-interacting protein 2 [IPR032747]", "Nuclear mitotic apparatus protein 1 [IPR026650]", "Nuclear polyadenylated RNA-binding protein Nab2/ZC3H14 [IPR040366]", "Nuclear pore complex protein NUP98-NUP96 [IPR037637]", "Nuclear pore complex protein Nup133-like [IPR037624]", "Nuclear pore complex protein [IPR026054]", "Nuclear pore glycoprotein p62, metazoa [IPR033072]", "Nuclear pore membrane glycoprotein 210-like [IPR045197]", "Nuclear pore protein 84/107 [IPR007252]", "Nuclear protein localization protein 4 [IPR016563]", "Nuclear transport factor 2/Mtr2 [IPR045875]", "Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 [IPR026633]", "Nucleobindin [IPR040250]", "Nucleobindin-1 [IPR040253]", "Nucleobindin-2 [IPR028813]", "Nucleolar GTP-binding protein 1 [IPR024926]", "Nucleolar GTP-binding protein 2 [IPR024929]", "Nucleolar complex protein 2 [IPR005343]", "Nucleolar complex protein 4 [IPR027193]", "Nucleolar complex-associated protein 3 [IPR016903]", "Nucleolar pre-ribosomal-associated protein 1 [IPR039844]", "Nucleolar protein 10/Enp2 [IPR040382]", "Nucleolar protein 11 [IPR042859]", "Nucleolar protein 14 [IPR007276]", "Nucleolar protein 7 [IPR039626]", "Nucleolar protein 9 [IPR040000]", "Nucleolar protein Nop56/Nop58 [IPR045056]", "Nucleolar, Nop52 [IPR010301]", "Nucleoplasmin family [IPR004301]", "Nucleoporin NSP1/NUP62 [IPR026010]", "Nucleoporin NUP88/NUP82 [IPR037700]", "Nucleoporin Nup120/160 [IPR021717]", "Nucleoporin Nup186/Nup192/Nup205 [IPR021827]", "Nucleoporin Nup188 [IPR044840]", "Nucleoporin Nup37 [IPR037626]", "Nucleoporin Nup54/Nup57/Nup44 [IPR024864]", "Nucleoporin Nup85-like [IPR011502]", "Nucleoporin Nup88 [IPR019321]", "Nucleoporin Seh1 [IPR037597]", "Nucleoporin interacting component Nup93/Nic96 [IPR007231]", "Nucleoporin peptidase S59-like [IPR037665]", "Nucleoporin protein Ndc1-Nup [IPR019049]", "Nucleoporin, NUP53 [IPR017389]", "Nucleoporin, Nup155-like [IPR004870]", "Nucleoside 2-deoxyribosyltransferase [IPR007710]", "Nucleoside diphosphate kinase [IPR001564]", "Nucleoside transporter ENT1/ENT2 [IPR034764]", "Nucleoside-triphosphatase, THEP1 type [IPR004948]", "Nucleosome assembly protein (NAP) [IPR002164]", "Nucleosome-remodeling factor subunit BPTF [IPR038028]", "NudC domain-containing protein 1 [IPR037895]", "NudC family [IPR037898]", "OBG-type GTPase [IPR045086]", "OCIA domain-containing protein 1/2 [IPR040187]", "ORC ubiquitin ligase 1 [IPR039209]", "Occludin [IPR002958]", "Oligoribonuclease [IPR022894]", "Oligosaccharyl transferase complex, subunit OST3/OST6 [IPR021149]", "Oligosaccharyl transferase, STT3 subunit [IPR003674]", "Optic atrophy 3-like [IPR010754]", "Ornithine aminotransferase [IPR010164]", "Orotate phosphoribosyltransferase [IPR023031]", "Orotidine 5'-phosphate decarboxylase [IPR014732]", "Oxidized purine nucleoside triphosphate [IPR003563]", "Oxysterol-binding protein [IPR000648]", "P-type ATPase [IPR001757]", "P-type ATPase subfamily IIC, subunit alpha [IPR005775]", "P-type ATPase, subfamily IIA, SERCA-type [IPR005782]", "P-type ATPase, subfamily V [IPR006544]", "P-type ATPase, subfamily IIB [IPR006408]", "PA2G4 family [IPR004545]", "PAT complex subunit CCDC47 [IPR012879]", "PCNA-associated factor [IPR040444]", "PDCD5-like [IPR002836]", "PDK/BCKDK protein kinase [IPR039028]", "PDZ and LIM domain protein 1 [IPR028537]", "PEST proteolytic signal-containing nuclear protein [IPR029169]", "PEX5/PEX5L [IPR024111]", "PHF5-like [IPR005345]", "PITH domain-containing protein 1-like [IPR045099]", "Pachytene checkpoint protein 2-like [IPR044539]", "Palmitoyl protein thioesterase [IPR002472]", "Palmitoyl-protein thioesterase 1 [IPR030294]", "Pantothenate kinase, acetyl-CoA regulated, two-domain type [IPR015844]", "Paraneoplastic encephalomyelitis antigen [IPR002343]", "Paraoxonase2 [IPR008364]", "Pentatricopeptide repeat domain-containing protein 3 [IPR037387]", "Peptidase A22B, signal peptide peptidase [IPR007369]", "Peptidase C13, legumain [IPR001096]", "Peptidase C14 family [IPR002398]", "Peptidase C1B, bleomycin hydrolase [IPR004134]", "Peptidase C2, calpain family [IPR022684]", "Peptidase C26 [IPR011697]", "Peptidase C26, gamma-glutamyl hydrolase [IPR015527]", "Peptidase C65, otubain [IPR019400]", "Peptidase C69, dipeptidase A [IPR005322]", "Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase [IPR001930]", "Peptidase M1, aminopeptidase B [IPR015571]", "Peptidase M13 [IPR000718]", "Peptidase M14B, caboxypeptidase D [IPR015567]", "Peptidase M17, leucine aminopeptidase [IPR023042]", "Peptidase M17, leucine aminopeptidase/peptidase B [IPR011356]", "Peptidase M20 [IPR002933]", "Peptidase M24, methionine aminopeptidase [IPR001714]", "Peptidase M24A, methionine aminopeptidase, subfamily 1 [IPR002467]", "Peptidase M28 family [IPR045175]", "Peptidase M3A/M3B [IPR045090]", "Peptidase S10, serine carboxypeptidase [IPR001563]", "Peptidase S26B [IPR001733]", "Peptidase S28 [IPR008758]", "Peptidase S8, subtilisin-related [IPR015500]", "Peptidase S9A, prolyl oligopeptidase [IPR002470]", "Peptidase T1A, proteasome beta-subunit [IPR000243]", "Peptidase family M49 [IPR039461]", "Peptidase, FtsH [IPR005936]", "Peptide chain release factor eRF1/aRF1 [IPR004403]", "Peptidyl-prolyl cis-trans isomerase E [IPR016304]", "Peptidyl-prolyl cis-trans isomerase FKBP3 [IPR043368]", "Peptidyl-prolyl cis-trans isomerase FKBP4 [IPR031212]", "Peptidyl-prolyl cis-trans isomerase FKBP5 [IPR031210]", "Peptidyl-prolyl cis-trans isomerase PIN4 [IPR043323]", "Peptidyl-tRNA hydrolase, PTH2 [IPR002833]", "Pericentriolar material 1 protein [IPR024138]", "Perilipin [IPR004279]", "Periodic tryptophan protein 1 [IPR044285]", "Periodic tryptophan protein 2 [IPR027145]", "Peroxiredoxin, AhpC-type [IPR024706]", "Peroxiredoxin-5-like [IPR037944]", "Peroxiredoxin-like 2A [IPR032802]", "Peroxiredoxin-like 2A/B/C [IPR032801]", "Peroxisomal acyl-coenzyme A oxidase [IPR034171]", "Peroxisomal biogenesis factor 11 [IPR008733]", "Peroxisomal membrane protein 11C, metazoa [IPR026510]", "Peroxisomal membrane protein 14 [IPR025655]", "Peroxisomal targeting signal 1 receptor PEX5, animals [IPR024113]", "Peroxysomal long chain fatty acyl transporter [IPR005283]", "Pescadillo [IPR010613]", "Pex19 protein [IPR006708]", "Phenylalanine-tRNA ligase, class IIc, beta subunit [IPR045060]", "Phenylalanyl-tRNA synthetase, class IIc, alpha subunit [IPR004529]", "Phenylalanyl-tRNA synthetase, class IIc, beta subunit, archael/eukaryotic type [IPR004531]", "Phosphatidate cytidylyltransferase [IPR000374]", "Phosphatidate cytidylyltransferase, eukaryota [IPR016720]", "Phosphatidate cytidylyltransferase, mitochondrial [IPR015222]", "Phosphatidyl serine synthase [IPR004277]", "Phosphatidylethanolamine-binding protein [IPR008914]", "Phosphatidylethanolamine-binding protein, eukaryotic [IPR035810]", "Phosphatidylinositol 3-kinase, Vps34 type [IPR008290]", "Phosphatidylinositol kinase [IPR015433]", "Phosphatidylinositol transfer protein [IPR001666]", "Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma [IPR016279]", "Phosphatidylinositol-4-phosphate 5-kinase [IPR023610]", "Phosphatidylinositol-binding clathrin assembly protein [IPR030412]", "Phosphatidylinositol-glycan biosynthesis class S protein [IPR019540]", "Phosphatidylserine decarboxylase [IPR033177]", "Phosphatidylserine decarboxylase, eukaryotic type 1 [IPR033661]", "Phosphatidylserine decarboxylase-related [IPR003817]", "Phosphodiesterase MJ0936/Vps29 [IPR000979]", "Phosphoenolpyruvate carboxykinase, GTP-utilising [IPR008209]", "Phosphoglucomutase [IPR045244]", "Phosphoglucose isomerase (PGI) [IPR001672]", "Phosphoglycerate kinase [IPR001576]", "Phosphoglycerate mutase 1 [IPR005952]", "Phosphoinositide phospholipase C family [IPR001192]", "Phospholipase B-like [IPR007000]", "Phosphoribosylformylglycinamidine cyclo-ligase [IPR004733]", "Phosphoribosylformylglycinamidine synthase PurL [IPR010073]", "Phosphoribosylglycinamide formyltransferase [IPR004607]", "Phosphoribosylglycinamide synthetase [IPR000115]", "Phosphoserine aminotransferase [IPR022278]", "Phosphotyrosyl phosphatase activator, PTPA [IPR004327]", "Pinin [IPR039853]", "Pirin [IPR012093]", "Plakin [IPR043197]", "Plakophilin/Delta catenin [IPR028435]", "Plasma membrane calcium-transporting ATPase 1 [IPR030320]", "Plasminogen activator inhibitor 1 RNA-binding protein [IPR027205]", "Plastin-2/3 [IPR039956]", "Plectin [IPR030269]", "Polo kinase kinase [IPR022165]", "Poly-U binding splicing factor, PUF60-like [IPR006532]", "Polyadenylate binding protein, human types 1, 2, 3, 4 [IPR006515]", "Polyadenylate-binding protein 2 [IPR034911]", "Polyprenyl synthetase [IPR000092]", "Polyribonucleotide 5-hydroxyl-kinase Clp1/Grc3 [IPR045116]", "Polyribonucleotide nucleotidyltransferase [IPR012162]", "Porin, eukaryotic type [IPR001925]", "Porphobilinogen deaminase [IPR000860]", "Pre-mRNA-processing factor 17 [IPR032847]", "Pre-mRNA-processing factor 19 [IPR038959]", "Pre-mRNA-processing factor 6/Prp1/STA1 [IPR027108]", "Pre-mRNA-processing factor Prp40 [IPR039726]", "Pre-mRNA-processing-splicing factor 8 [IPR027652]", "Pre-mRNA-splicing factor 38 [IPR005037]", "Pre-mRNA-splicing factor Cwc2/Slt11 [IPR039171]", "Pre-mRNA-splicing factor SPF27 [IPR008409]", "Pre-mRNA-splicing factor Spp2-like [IPR045166]", "Pre-mRNA-splicing factor Syf1-like [IPR045075]", "Pre-mRNA-splicing regulator WTAP [IPR033757]", "Pre-rRNA-processing protein Esf1 [IPR039754]", "Pre-rRNA-processing protein PNO1-like [IPR039912]", "Prefoldin alpha subunit, archaea-type [IPR011599]", "Prefoldin alpha-like [IPR004127]", "Prefoldin beta-like [IPR002777]", "Prefoldin subunit 2 [IPR027235]", "Prefoldin subunit 3 [IPR016655]", "Prefoldin, subunit 4 [IPR016661]", "Prenylated rab acceptor PRA1 [IPR004895]", "Prenylcysteine oxidase [IPR017046]", "Prenyltransferase subunit beta [IPR045089]", "Presenilin/signal peptide peptidase [IPR006639]", "Primosome PriB/single-strand DNA-binding [IPR000424]", "Probable ubiquitin carboxyl-terminal hydrolase FAF-X [IPR031226]", "Profilin [IPR005455]", "Profilin-1 [IPR029892]", "Profilin-2 [IPR029891]", "Profilin1/2/3, vertebrate [IPR005454]", "Programmed cell death protein 4 [IPR039778]", "Prohibitin [IPR000163]", "Proliferating cell nuclear antigen, PCNA [IPR000730]", "Proline-rich protein PRCC [IPR018800]", "Proline-tRNA ligase, class IIa, archaeal-type [IPR004499]", "Prolyl 3-hydroxylase 1 [IPR039837]", "Prolyl 3-hydroxylase [IPR039575]", "Prolyl 4-hydroxylase [IPR045054]", "Prostaglandin E synthase 2 [IPR034334]", "Prostaglandin reductase 2 [IPR037399]", "Proteasome B-type subunit [IPR023333]", "Proteasome activator PA28 [IPR009077]", "Proteasome activator complex subunit 4 [IPR035309]", "Proteasome alpha-type subunit [IPR023332]", "Proteasome assembly chaperone 1 [IPR016565]", "Proteasome assembly chaperone 3 [IPR018788]", "Proteasome beta 3 subunit [IPR033811]", "Proteasome component Ecm29 [IPR024372]", "Proteasome inhibitor PI31-like [IPR045128]", "Proteasome subunit alpha 1 [IPR035144]", "Proteasome subunit alpha 3 [IPR037555]", "Proteasome subunit alpha 7 [IPR035190]", "Proteasome subunit alpha2 [IPR034644]", "Proteasome subunit alpha4 [IPR034647]", "Proteasome subunit alpha5 [IPR033812]", "Proteasome subunit alpha6 [IPR034642]", "Proteasome subunit beta 1 [IPR035202]", "Proteasome subunit beta 2 [IPR035206]", "Proteasome subunit beta 4 [IPR016295]", "Proteasome subunit beta 5 [IPR037558]", "Proteasome subunit beta 6 [IPR035140]", "Proteasome subunit beta 7 [IPR035216]", "Proteasome, subunit alpha/beta [IPR001353]", "Protein AATF/Bfr2 [IPR039223]", "Protein BRAWNIN [IPR027858]", "Protein CDV3 [IPR026806]", "Protein CIP2A [IPR042510]", "Protein CUSTOS [IPR026694]", "Protein Cms1 [IPR032704]", "Protein DEK [IPR044198]", "Protein ERGIC-53 [IPR033085]", "Protein FAM3C [IPR039219]", "Protein FAM8A1 [IPR039871]", "Protein Hgh1 [IPR039717]", "Protein ICln/Lot5/Saf5 [IPR039924]", "Protein LYRIC [IPR031402]", "Protein LZIC [IPR040065]", "Protein Lsm12-like [IPR039683]", "Protein Mon2-like [IPR026829]", "Protein NDRG3 [IPR030692]", "Protein PBDC1, metazoa/fungi [IPR008476]", "Protein PRRC1 [IPR026534]", "Protein PRRC2 [IPR033184]", "Protein Peter Pan-like [IPR045112]", "Protein RCC2 [IPR028641]", "Protein Red-like [IPR039896]", "Protein S100-A10 [IPR028476]", "Protein S100-A11 [IPR028482]", "Protein S100-A13 [IPR028487]", "Protein SON [IPR032922]", "Protein Sgt1-like [IPR044563]", "Protein TFG [IPR033512]", "Protein XRP2 [IPR039093]", "Protein arginine N-methyltransferase PRMT5 [IPR007857]", "Protein arginine N-methyltransferase [IPR025799]", "Protein arginine methyltransferase NDUFAF7 [IPR003788]", "Protein canopy homolog [IPR042415]", "Protein disulfide-isomerase A6-like [IPR044569]", "Protein disulphide isomerase [IPR005792]", "Protein disulphide-isomerase A4 [IPR017068]", "Protein farnesyltransferase subunit beta [IPR026872]", "Protein flightless-1 [IPR029919]", "Protein furry/Tao3/Mor2 [IPR039867]", "Protein import receptor MAS20 [IPR002056]", "Protein import receptor MAS20, metazoan [IPR022422]", "Protein kinase C and casein kinase substrate in neurons protein 2 [IPR028521]", "Protein kinase C and casein kinase substrate in neurons protein 3 [IPR028523]", "Protein of unknown function DUF1075 [IPR009432]", "Protein of unknown function DUF2046 [IPR019152]", "Protein of unknown function DUF4726 [IPR031714]", "Protein of unknown function DUF719 [IPR007998]", "Protein patched/dispatched [IPR003392]", "Protein phosphatase 1 regulatory subunit 12A/B/C [IPR017401]", "Protein phosphatase 2A regulatory subunit PR55 [IPR000009]", "Protein phosphatase 2A, regulatory B subunit, B56 [IPR002554]", "Protein phosphatase 2C family [IPR015655]", "Protein phosphatase methylesterase, eukaryotic [IPR016812]", "Protein regulator of cytokinesis 1 [IPR032921]", "Protein transport Sec61-beta/Sbh [IPR030671]", "Protein transport protein Got1 [IPR045176]", "Protein transport protein SEC31-like [IPR040251]", "Protein transport protein Sec23 [IPR037364]", "Protein transport protein SecG/Sec61-beta/Sbh [IPR016482]", "Protein unc-119 homologue A-like [IPR032977]", "Protein virilizer [IPR026736]", "Protein-L-isoaspartate(D-aspartate) O-methyltransferase [IPR000682]", "Protein-S-isoprenylcysteine O-methyltransferase [IPR025770]", "Protein-glutamate O-methyltransferase [IPR039763]", "Protein-tyrosine phosphatase, low molecular weight [IPR017867]", "Protein-tyrosine phosphatase, low molecular weight, mammalian [IPR002115]", "Protein-tyrosine phosphatase, non-receptor type-1/2 [IPR012265]", "Protein-tyrosine phosphatase-like, PTPLA [IPR007482]", "Protein/nucleic acid deglycase DJ-1 [IPR006287]", "Proteinase inhibitor I25A, stefin [IPR001713]", "Protoporphyrinogen oxidase [IPR004572]", "Pseudouridine synthase, TruD [IPR001656]", "Pterin 4 alpha carbinolamine dehydratase [IPR001533]", "Pumilio homologue 3 [IPR040059]", "Purine 5'-nucleotidase [IPR016695]", "Purine nucleoside phosphorylase I, inosine/guanosine-specific [IPR011270]", "Purine nucleoside phosphorylase [IPR011268]", "Purine-rich element binding protein family [IPR006628]", "Purine-rich element-binding protein alpha [IPR030500]", "Putative RNA methyltransferase [IPR003750]", "Putative peptidyl-tRNA hydrolase PTRHD1 [IPR042237]", "Pyridine nucleotide-disulphide oxidoreductase, class I [IPR001100]", "Pyridoxal phosphate-dependent decarboxylase [IPR002129]", "Pyridoxine kinase [IPR004625]", "Pyrimidine 5'-nucleotidase, eukaryotic [IPR006434]", "Pyrroline-5-carboxylate reductase [IPR000304]", "Pyruvate carboxylase [IPR005930]", "Pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit, subgroup y [IPR017597]", "Pyruvate dehydrogenase E1 component subunit beta [IPR027110]", "Pyruvate kinase [IPR001697]", "RAB11-binding protein RELCH [IPR040362]", "RAD3/XPD family [IPR001945]", "RFX-like DNA-binding protein [IPR039779]", "RINT-1/Tip20 [IPR007528]", "RLI1 [IPR013283]", "RNA (C5-cytosine) methyltransferase [IPR023267]", "RNA (C5-cytosine) methyltransferase, NOP2 [IPR023273]", "RNA 3'-terminal phosphate cyclase [IPR000228]", "RNA 3'-terminal phosphate cyclase type 2 [IPR016443]", "RNA binding protein HABP4/SERBP1 [IPR039764]", "RNA cytidine acetyltransferase NAT10 [IPR033688]", "RNA demethylase ALKBH5 [IPR032860]", "RNA exonuclease 4 [IPR034920]", "RNA polymerase I associated factor, A49-like [IPR009668]", "RNA polymerase II associated factor Paf1 [IPR007133]", "RNA polymerase II transcriptional coactivator Sub1/Tcp4-like [IPR045125]", "RNA polymerase II-associated protein RPAP1/Rba50 [IPR039913]", "RNA polymerase subunit Rpb7-like [IPR045113]", "RNA polymerase-associated protein Ctr9 [IPR031101]", "RNA transcription, translation and transport factor protein [IPR019265]", "RNA-binding motif protein 8 [IPR008111]", "RNA-binding protein 10 [IPR033095]", "RNA-binding protein 26 [IPR034861]", "RNA-binding protein 26/27 [IPR045137]", "RNA-binding protein 5 [IPR033094]", "RNA-binding protein EWS [IPR033109]", "RNA-binding protein FUS [IPR034459]", "RNA-induced silencing complex, nuclease component Tudor-SN [IPR016685]", "RNA-splicing ligase RtcB homologue, eukaryotic [IPR027513]", "RNA-splicing ligase, RtcB [IPR001233]", "RNase P subunit p30 [IPR002738]", "RPA-related protein RADX [IPR040893]", "RZZ complex, subunit Zw10 [IPR009361]", "Rab GDI protein [IPR000806]", "Rab GTPase-activating protein 1 [IPR033185]", "Rab protein geranylgeranyltransferase component A [IPR001738]", "Rab24 [IPR041828]", "Rab3GAP catalytic subunit [IPR045700]", "Rab3GAP regulatory subunit [IPR026059]", "Rab9 [IPR041824]", "Rabaptin [IPR003914]", "Rabaptin-5 [IPR029880]", "Rad21/Rec8-like protein [IPR039781]", "Rad9 [IPR026584]", "Rad9/Ddc1 [IPR007268]", "RalBP1-associated Eps domain-containing protein 1 [IPR026814]", "Ran GTPase [IPR002041]", "Ran binding protein RanBP1-like [IPR045255]", "Rap guanine nucleotide exchange factor 2 [IPR030739]", "Rap1 GTPase-GDP dissociation stimulator 1 [IPR040144]", "Ras GTPase GNL1-like [IPR043358]", "Ras GTPase-activating protein-binding protein 1 [IPR034375]", "Ras GTPase-activating protein-binding protein 2 [IPR034377]", "Ras GTPase-activating protein-binding protein [IPR039539]", "Ras-like guanine nucleotide exchange factor [IPR008937]", "Ras-related protein Rab14 [IPR030702]", "Ras-related protein Ral [IPR028412]", "Reduced folate carrier [IPR002666]", "Reduced folate transporter SLC19A1 [IPR028339]", "Remodeling and spacing factor 1-like [IPR028938]", "Remodelling complex subunit Rsc/polybromo [IPR037382]", "Replication factor A protein 1 [IPR004591]", "Replication factor A protein 2 [IPR014646]", "Replication factor A protein-like [IPR040260]", "Replication factor C subunit 1 [IPR012178]", "Reticulon-4-interacting protein 1 [IPR037397]", "Retinal rod rhodopsin-sensitive cGMP 3', 5'-cyclic phosphodiesterase, delta subunit [IPR017287]", "Retinoblastoma-binding protein 5/Swd1 [IPR037850]", "Retrieval of early ER protein Rer1 [IPR004932]", "Rho protein GDP-dissociation inhibitor [IPR000406]", "Rho-associated protein kinase 1/2 [IPR020684]", "Rho-related GTP-binding protein RhoG [IPR042734]", "Ribonuclease CAF1 [IPR006941]", "Ribonuclease H2, subunit A [IPR004649]", "Ribonuclease HII/HIII [IPR001352]", "Ribonuclease III [IPR011907]", "Ribonuclease T2, eukaryotic [IPR033697]", "Ribonuclease T2-like [IPR001568]", "Ribonucleases P/MRP protein subunit Pop1 [IPR039182]", "Ribonucleoprotein PTB-binding 1 [IPR034635]", "Ribonucleoside-diphosphate reductase large subunit [IPR039718]", "Ribonucleotide reductase small subunit [IPR033909]", "Ribonucleotide reductase small subunit family [IPR000358]", "Ribophorin I [IPR007676]", "Ribose-phosphate pyrophosphokinase [IPR005946]", "Ribose-phosphate pyrophosphokinase, bacterial-type [IPR037515]", "Ribosomal RNA large subunit methyltransferase E [IPR015507]", "Ribosomal RNA processing protein 8 [IPR007823]", "Ribosomal RNA-processing protein 15 [IPR012459]", "Ribosomal biogenesis NSA2 family [IPR039411]", "Ribosomal biogenesis regulatory protein [IPR007023]", "Ribosomal biogenesis, methyltransferase, EMG1/NEP1 [IPR005304]", "Ribosomal export protein Nmd3 [IPR039768]", "Ribosomal protein L1 [IPR002143]", "Ribosomal protein L1, mitochondrial [IPR005879]", "Ribosomal protein L1/ribosomal biogenesis protein [IPR028364]", "Ribosomal protein L10P [IPR001790]", "Ribosomal protein L10e [IPR001197]", "Ribosomal protein L11, bacterial-type [IPR006519]", "Ribosomal protein L11/L12 [IPR000911]", "Ribosomal protein L12/P1/P2 family [IPR027534]", "Ribosomal protein L13 [IPR005822]", "Ribosomal protein L13, eukaryotic/archaeal [IPR005755]", "Ribosomal protein L13e [IPR001380]", "Ribosomal protein L14 [IPR039660]", "Ribosomal protein L14P [IPR000218]", "Ribosomal protein L15 [IPR030878]", "Ribosomal protein L15, bacterial-type [IPR005749]", "Ribosomal protein L15e [IPR000439]", "Ribosomal protein L17 [IPR000456]", "Ribosomal protein L18e [IPR000039]", "Ribosomal protein L19 [IPR001857]", "Ribosomal protein L2 [IPR002171]", "Ribosomal protein L2, archaeal-type [IPR023672]", "Ribosomal protein L20 [IPR005813]", "Ribosomal protein L21 [IPR001787]", "Ribosomal protein L21-like [IPR028909]", "Ribosomal protein L21e [IPR001147]", "Ribosomal protein L22/L17 [IPR001063]", "Ribosomal protein L22/L17, eukaryotic/archaeal [IPR005721]", "Ribosomal protein L22e [IPR002671]", "Ribosomal protein L23 [IPR019985]", "Ribosomal protein L24e-related [IPR000988]", "Ribosomal protein L25/L23 [IPR013025]", "Ribosomal protein L27e [IPR001141]", "Ribosomal protein L28/L40, mitochondrial [IPR019192]", "Ribosomal protein L28e [IPR002672]", "Ribosomal protein L29/L35 [IPR001854]", "Ribosomal protein L29e [IPR002673]", "Ribosomal protein L3 [IPR000597]", "Ribosomal protein L3, archaeal/eukaryotic type [IPR045077]", "Ribosomal protein L30/YlxQ [IPR039109]", "Ribosomal protein L30e [IPR000231]", "Ribosomal protein L31e [IPR000054]", "Ribosomal protein L32e [IPR001515]", "Ribosomal protein L34Ae [IPR008195]", "Ribosomal protein L35A [IPR001780]", "Ribosomal protein L36e [IPR000509]", "Ribosomal protein L37/S30 [IPR010793]", "Ribosomal protein L37ae [IPR002674]", "Ribosomal protein L37e [IPR001569]", "Ribosomal protein L38e [IPR002675]", "Ribosomal protein L4, eukaryotic and archaeal type [IPR045240]", "Ribosomal protein L4/L1e [IPR002136]", "Ribosomal protein L44e [IPR000552]", "Ribosomal protein L47, mitochondrial [IPR010729]", "Ribosomal protein L49/IMG2 [IPR007740]", "Ribosomal protein L5 [IPR002132]", "Ribosomal protein L5 eukaryotic/L18 archaeal [IPR005485]", "Ribosomal protein L50, mitochondria [IPR018305]", "Ribosomal protein L53, mitochondrial [IPR019716]", "Ribosomal protein L6 [IPR000702]", "Ribosomal protein L7, eukaryotic [IPR005998]", "Ribosomal protein L7/L12 [IPR000206]", "Ribosomal protein L7/L30 [IPR039699]", "Ribosomal protein L7A/L8 [IPR001921]", "Ribosomal protein L7Ae/L8/Nhp2 family [IPR018492]", "Ribosomal protein L9 [IPR000244]", "Ribosomal protein P2 [IPR044076]", "Ribosomal protein S10 [IPR001848]", "Ribosomal protein S10, eukaryotic/archaeal [IPR005729]", "Ribosomal protein S11 [IPR001971]", "Ribosomal protein S12/S23 [IPR006032]", "Ribosomal protein S12e [IPR000530]", "Ribosomal protein S13 [IPR001892]", "Ribosomal protein S15 [IPR000589]", "Ribosomal protein S15, bacterial-type [IPR005290]", "Ribosomal protein S15P [IPR023029]", "Ribosomal protein S17, archaeal/eukaryotic [IPR028333]", "Ribosomal protein S17/S11 [IPR000266]", "Ribosomal protein S17e [IPR001210]", "Ribosomal protein S19/S15 [IPR002222]", "Ribosomal protein S19A/S15e [IPR005713]", "Ribosomal protein S19e [IPR001266]", "Ribosomal protein S2 [IPR001865]", "Ribosomal protein S2, bacteria/mitochondria/plastid [IPR005706]", "Ribosomal protein S2, eukaryotic [IPR027498]", "Ribosomal protein S2, eukaryotic/archaeal [IPR005707]", "Ribosomal protein S21e [IPR001931]", "Ribosomal protein S22, mitochondrial [IPR019374]", "Ribosomal protein S23, eukaryotic/archaeal [IPR005680]", "Ribosomal protein S23, mitochondrial [IPR019520]", "Ribosomal protein S23/S29, mitochondrial [IPR019368]", "Ribosomal protein S24/S35, mitochondrial [IPR039848]", "Ribosomal protein S24e [IPR001976]", "Ribosomal protein S25 [IPR004977]", "Ribosomal protein S28e [IPR000289]", "Ribosomal protein S29, mitochondrial [IPR008092]", "Ribosomal protein S3, eukaryotic/archaeal [IPR005703]", "Ribosomal protein S30 [IPR006846]", "Ribosomal protein S30, mitochondrial [IPR039982]", "Ribosomal protein S3Ae [IPR001593]", "Ribosomal protein S4/S9 [IPR022801]", "Ribosomal protein S4/S9, eukaryotic/archaeal [IPR005710]", "Ribosomal protein S4e [IPR000876]", "Ribosomal protein S5 [IPR000851]", "Ribosomal protein S5, eukaryotic/archaeal [IPR005711]", "Ribosomal protein S5/S7 [IPR000235]", "Ribosomal protein S5/S7, eukaryotic/archaeal [IPR005716]", "Ribosomal protein S6 kinase II [IPR016239]", "Ribosomal protein S6, eukaryotic [IPR014401]", "Ribosomal protein S6e [IPR001377]", "Ribosomal protein S7e [IPR000554]", "Ribosomal protein S8 [IPR000630]", "Ribosomal protein S8e [IPR001047]", "Ribosomal protein S8e/ribosomal biogenesis NSA2 [IPR022309]", "Ribosomal protein S9 [IPR000754]", "Ribosome assembly factor Mrt4 [IPR033867]", "Ribosome biogenesis factor, NIP7 [IPR016686]", "Ribosome biogenesis protein BRX1 [IPR026532]", "Ribosome biogenesis protein Bms1/Tsr1 [IPR039761]", "Ribosome biogenesis protein Nop16 [IPR019002]", "Ribosome biogenesis protein Rpf2 [IPR039770]", "Ribosome maturation protein Sdo1/SBDS [IPR002140]", "Ribosome maturation protein Sdo1/SBDS-like [IPR039100]", "Ribosome-binding ATPase YchF/Obg-like ATPase 1 [IPR004396]", "Ribosome-binding protein 1 [IPR040248]", "RidA family [IPR006056]", "RuvB-like [IPR027238]", "RuvB-like helicase 1 [IPR037938]", "RuvB-like helicase 2 [IPR037942]", "S-adenosylmethionine synthetase [IPR002133]", "S-formylglutathione hydrolase [IPR014186]", "S-phase kinase-associated protein 1 [IPR016897]", "S-phase kinase-associated protein 1-like [IPR001232]", "SAC3/GANP/THP3 [IPR045107]", "SAFB-like transcription modulator [IPR034780]", "SCAMP [IPR007273]", "SERRATE/Ars2 [IPR039727]", "SH3-binding, glutamic acid-rich protein [IPR006993]", "SHC SH2 domain-binding protein 1-like [IPR045140]", "SKI-interacting protein, SKIP [IPR017862]", "SLAIN motif-containing protein [IPR026179]", "SNARE associated Golgi protein [IPR032816]", "SNU66/SART1 family [IPR005011]", "SNX17/27/31 [IPR037831]", "SOUL haem-binding protein [IPR006917]", "SSNA1 family [IPR033362]", "SUMO-activating enzyme subunit Uba2 [IPR030661]", "SUN domain-containing protein 1 [IPR018539]", "SUN domain-containing protein 1-5 [IPR045119]", "SURP and G-patch domain-containing protein 1/2 [IPR040169]", "SWI/SNF complex subunit BAF57 [IPR030089]", "SWI/SNF complex subunit BRG1 [IPR030100]", "SWI/SNF complex subunit SMARCC1 [IPR030087]", "SWI/SNF complex subunit SMARCC2 [IPR038044]", "SWI/SNF-like complex subunit BAF250a [IPR030094]", "SWI/SNF-like complex subunit BAF250/Osa [IPR021906]", "Saf4/Yju2 protein [IPR007590]", "Saposin [IPR008373]", "Saposin, chordata [IPR021165]", "Sas10/Utp3/C1D [IPR007146]", "Scaffold attachment factor B1 [IPR034781]", "Scaffold attachment factor B2 [IPR034782]", "Scavenger mRNA decapping enzyme DcpS/DCS2 [IPR008594]", "Schlafen family [IPR029684]", "Sec1-like protein [IPR001619]", "Sec13/Seh1 family [IPR037363]", "Sec20 [IPR005606]", "SecY/SEC61-alpha family [IPR002208]", "Selenophosphate synthetase [IPR004536]", "Sentrin-specific protease 3 [IPR037945]", "Sepiapterin reductase [IPR006393]", "Septin 2 [IPR008113]", "Septin 7 [IPR008115]", "Septin 9 [IPR030645]", "Septin [IPR016491]", "Serine hydroxymethyltransferase [IPR001085]", "Serine-tRNA ligase, type1 [IPR002317]", "Serine/arginine-rich splicing factor 10 [IPR034476]", "Serine/arginine-rich splicing factor 11 [IPR034447]", "Serine/arginine-rich splicing factor 6 [IPR029541]", "Serine/threonine protein phosphatase 5 [IPR011236]", "Serine/threonine-protein kinase PAK2 [IPR035065]", "Serine/threonine-protein kinase TOR [IPR026683]", "Serine/threonine-protein phosphatase 2A subunit A, metazoa [IPR031090]", "Serine/threonine-protein phosphatase PP1-alpha catalytic subunit [IPR037979]", "Serpin H1 [IPR033547]", "Serpin family [IPR000215]", "Shootin-1 [IPR024849]", "Short transmembrane mitochondrial protein 1 [IPR027854]", "Short-chain dehydrogenase/reductase SDR [IPR002347]", "Sideroflexin-4 [IPR028825]", "Sigma intracellular receptor 2 [IPR016964]", "Signal peptidase complex catalytic subunit SEC11A [IPR037712]", "Signal peptidase complex subunit Spc2/SPCS2 [IPR009582]", "Signal recognition particle SRP9 [IPR039914]", "Signal recognition particle receptor, beta subunit [IPR019009]", "Signal recognition particle subunit SRP68 [IPR026258]", "Signal recognition particle, SRP14 subunit [IPR003210]", "Signal recognition particle, SRP54 subunit [IPR022941]", "Signal recognition particle, SRP54 subunit, eukaryotic [IPR006325]", "Signal recognition particle, SRP72 subunit [IPR026270]", "Signal recognition particle, SRP9 subunit [IPR008832]", "Sin3 associated polypeptide p18 [IPR010516]", "Single-stranded DNA-binding protein [IPR011344]", "Sirtuin family [IPR003000]", "Sister chromatid cohesion protein Pds5 [IPR039776]", "Ski3/TTC37 [IPR039226]", "Sm-like protein Lsm6/SmF [IPR016487]", "Sm-like protein Lsm7 [IPR017132]", "Sm-like protein Lsm7/SmG [IPR044641]", "Smac/DIABLO protein [IPR015142]", "Small (40S) ribosomal subunit Asc1/RACK1 [IPR045223]", "Small GTPase Rho [IPR003578]", "Small GTPase [IPR001806]", "Small GTPase superfamily, ARF type [IPR024156]", "Small GTPase superfamily, ARF/SAR type [IPR006689]", "Small GTPase superfamily, SAR1-type [IPR006687]", "Small GTPase, Ras-type [IPR020849]", "Small acidic protein [IPR026714]", "Small nuclear ribonucleoprotein E [IPR027078]", "Small nuclear ribonucleoprotein Sm D2 [IPR027248]", "Small nuclear ribonucleoprotein Sm D3 [IPR034099]", "Small-subunit processome, Utp11 [IPR007144]", "Small-subunit processome, Utp14 [IPR006709]", "Smooth muscle protein/calponin [IPR003096]", "Snf7 family [IPR005024]", "Sodium/potassium-transporting ATPase subunit beta [IPR000402]", "Sodium:dicarboxylate symporter [IPR001991]", "Solute carrier family 35 member SLC35F1/F2/F6 [IPR009262]", "Sorbitol dehydrogenase-like [IPR045306]", "Sororin protein [IPR018605]", "Sorting nexin 9 family [IPR014536]", "Sorting nexin-1 [IPR028660]", "Sorting nexin-17 [IPR028666]", "Sorting nexin-2 [IPR028653]", "Sorting nexin-27 [IPR028667]", "Sorting nexin-5 [IPR028654]", "Sorting nexin-5/6/32 [IPR014637]", "Sorting nexin-6 [IPR028657]", "Sorting nexin-9 [IPR028644]", "Spartin-like [IPR045036]", "Spectrin, beta subunit [IPR016343]", "Spermatid perinuclear RNA-binding protein [IPR030446]", "Spermatogenesis-defective protein 39 [IPR040057]", "Spermidine/spermine synthase, eukaryotes [IPR030668]", "Spermidine/spermine synthases [IPR001045]", "Sphingomyelin phosphodiesterase 4 [IPR024129]", "Sphingosine N-acyltransferase Lag1/Lac1-like [IPR016439]", "Spindle assembly checkpoint component Mad1 [IPR008672]", "Splicing factor 3A subunit 1 [IPR045146]", "Splicing factor 3A subunit 3 [IPR031776]", "Splicing factor 3B subunit 1-like [IPR038737]", "Splicing factor 45 [IPR040052]", "Splicing factor ELAV/Hu [IPR006548]", "Splicing factor Yju2 [IPR043701]", "Splicing factor, RBM39-like [IPR006509]", "Splicing factor, arginine/serine-rich 19 [IPR042841]", "Squalene cyclase [IPR018333]", "Squalene monooxygenase [IPR040125]", "Squalene synthase-like [IPR006449]", "Squalene/phytoene synthase [IPR002060]", "Stathmin family [IPR000956]", "Steroidogenic acute regulatory protein-like [IPR000799]", "Sterol O-acyltransferase, ACAT/DAG/ARE types [IPR014371]", "Sterol O-acyltransferase, metazoa [IPR030687]", "Stomatin [IPR028515]", "Stomatin/HflK/HflC family [IPR001972]", "Structural maintenance of chromosomes flexible hinge domain-containing protein 1 [IPR038892]", "Structural maintenance of chromosomes protein 1A, metazoan [IPR029683]", "Structural maintenance of chromosomes protein [IPR024704]", "Structure-specific recognition protein [IPR000969]", "Succinate dehydrogenase, flavoprotein subunit [IPR011281]", "Succinate dehydrogenase/fumarate reductase iron-sulphur protein [IPR004489]", "Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [IPR014006]", "Succinate semialdehyde dehydrogenase [IPR010102]", "Succinate--CoA synthetase, beta subunit [IPR005809]", "Succinyl-CoA ligase, alpha subunit [IPR005810]", "Sugar/inositol transporter [IPR003663]", "Sulfotransferase [IPR005331]", "Sulfurtransferase TST/MPST-like [IPR045078]", "Suppressor of white apricot [IPR040397]", "Surface antigen D15-like [IPR039910]", "Surfeit locus 1/4 [IPR045214]", "Surfeit locus 4 [IPR002995]", "Surfeit locus 6 [IPR007019]", "Symplekin/Pta1 [IPR021850]", "Synaptic vesicle protein SV2 [IPR022308]", "Synaptobrevin [IPR001388]", "Synaptogyrin [IPR016579]", "Syntaxin [IPR045242]", "Synthesis of cytochrome c oxidase, Sco1/Sco2 [IPR017276]", "T-complex protein 1, alpha subunit [IPR012715]", "T-complex protein 1, beta subunit [IPR012716]", "T-complex protein 1, delta subunit [IPR012717]", "T-complex protein 1, epsilon subunit [IPR012718]", "T-complex protein 1, eta subunit [IPR012720]", "T-complex protein 1, gamma subunit [IPR012719]", "T-complex protein 1, theta subunit [IPR012721]", "T-complex protein 1, zeta subunit [IPR012722]", "TACC family [IPR039915]", "TAF15/EWS/TLS family [IPR034870]", "TAP46-like protein [IPR007304]", "TATA binding associated factor 15 [IPR034875]", "TATA-binding protein-associated factor Mot1 [IPR044972]", "TB2/DP1/HVA22-related protein [IPR004345]", "TE2IP/Rap1 [IPR039595]", "TH1 protein [IPR006942]", "THO complex subunit 2 [IPR040007]", "THO complex subunit 6 [IPR042626]", "THO complex, subunit THOC1 [IPR021861]", "THRAP3/BCLAF1 family [IPR029199]", "THUMP domain-containing protein 1-like [IPR040183]", "TIP41-like protein [IPR007303]", "TMEM14 family [IPR005349]", "TMEM192 family [IPR029399]", "TMEM33/Pom33 family [IPR005344]", "TMEM85/ER membrane protein complex subunit 4 [IPR009445]", "TOX high mobility group box family member 4 [IPR037985]", "TPX2 [IPR009675]", "TRAPP I complex, subunit 5 [IPR016696]", "TREX component Tex1/THOC3 [IPR040132]", "Tankyrase 1-binding protein-like [IPR040006]", "TatSF1-like [IPR034393]", "Taxilin family [IPR026183]", "Telomerase RNA component interacting RNase [IPR038838]", "Telomere-associated protein Rif1 [IPR028566]", "Testis-expressed protein 10/pre-rRNA-processing protein Ipi1 [IPR037947]", "Tetrahydrofolate dehydrogenase/cyclohydrolase [IPR000672]", "Tetraspanin, animals [IPR000301]", "Tetraspanin/Peripherin [IPR018499]", "Tetratricopeptide repeat protein 19 [IPR040395]", "Tetratricopeptide repeat protein 26 [IPR030511]", "Tetratricopeptide repeat protein 38 [IPR033891]", "The Golgi pH regulator/GPCR-type G protein [IPR015672]", "ThiF/MoeB/HesA family [IPR045886]", "Thiamine pyrophosphate enzyme [IPR045229]", "Thiolase [IPR002155]", "Thioredoxin domain-containing protein 17-like [IPR045108]", "Thioredoxin-related transmembrane protein 2 [IPR039101]", "Thioredoxin/glutathione reductase selenoprotein [IPR006338]", "Threonine-tRNA ligase, class IIa [IPR002320]", "Thymidine kinase [IPR001267]", "Thymidylate kinase [IPR018094]", "Thymidylate synthase [IPR000398]", "Thymidylate synthase/dCMP hydroxymethylase [IPR045097]", "Thyroid hormone receptor-associated protein 3 [IPR026667]", "Tight junction protein ZO [IPR005417]", "Tight junction protein ZO-1 [IPR005418]", "Tim23-like [IPR045238]", "Tim44-like [IPR039544]", "Tissue alpha-L-fucosidase [IPR028755]", "TmcA/NAT10/Kre33 [IPR032672]", "Tom40 [IPR037930]", "Torsin-1A-interacting protein 1/2 [IPR008662]", "TraB/PrgY/GumN family [IPR002816]", "Trans-isoprenyl diphosphate synthases, eukaryotic-type [IPR044844]", "Transaldolase type 1 [IPR004730]", "Transaldolase/Fructose-6-phosphate aldolase [IPR001585]", "Transcription elongation factor SPT5 [IPR039659]", "Transcription elongation factor Spt5, eukaryote [IPR017071]", "Transcription elongation factor Spt6 [IPR017072]", "Transcription elongation factor, IIS-type [IPR035100]", "Transcription elongation factor, TFIIS [IPR006289]", "Transcription elongation regulator 1-like [IPR045148]", "Transcription facto Tfc3-like [IPR044210]", "Transcription factor BTF3 [IPR039370]", "Transcription factor E [IPR039997]", "Transcription factor II-I [IPR016659]", "Transcription factor STAT [IPR001217]", "Transcription factor TFIIB [IPR000812]", "Transcription factor Tfc4/TFIIIC-102/Sfc4 [IPR039340]", "Transcription initiation factor IIF, alpha subunit [IPR008851]", "Transcription initiation factor IIF, beta subunit [IPR003196]", "Transcription intermediary factor 1-beta [IPR037373]", "Transcriptional repressor p66 [IPR040386]", "Transferrin receptor protein 1 [IPR029513]", "Transforming growth factor-beta-related [IPR015615]", "Transgelin-2 [IPR001061]", "Translation Initiation factor eIF- 4e [IPR001040]", "Translation elongation factor EF1A, eukaryotic/archaeal [IPR004539]", "Translation elongation factor EFG/EF2 [IPR004540]", "Translation elongation factor EFTs/EF1B [IPR001816]", "Translation elongation factor EFTu/EF1A, bacterial/organelle [IPR004541]", "Translation elongation factor IF5A-like [IPR001884]", "Translation initiation factor 2, alpha subunit [IPR011488]", "Translation initiation factor 2A [IPR011387]", "Translation initiation factor 3 complex subunit L [IPR019382]", "Translation initiation factor IF- 2 [IPR015760]", "Translation initiation factor IF2/IF5 [IPR045196]", "Translation initiation factor IF6 [IPR002769]", "Translation machinery-associated protein 16 [IPR021346]", "Translation release factor pelota [IPR004405]", "Translational activator Gcn1 [IPR033173]", "Translationally controlled tumour protein [IPR018105]", "Translin [IPR033956]", "Translin family [IPR002848]", "Translocation associated membrane protein [IPR016447]", "Translocation protein Sec62 [IPR004728]", "Translocation protein Sec63 [IPR027137]", "Translocon-associated [IPR008855]", "Translocon-associated protein (TRAP), alpha subunit [IPR005595]", "Transmembrane emp24 domain-containing protein 5 [IPR015717]", "Transmembrane emp24 domain-containing protein 7 [IPR015718]", "Transmembrane emp24 domain-containing protein [IPR015720]", "Transmembrane protein 109 [IPR039492]", "Transmembrane protein 126 [IPR009801]", "Transmembrane protein 160 [IPR026801]", "Transmembrane protein 201 [IPR040041]", "Transmembrane protein 205 [IPR042623]", "Transmembrane protein 214 [IPR019308]", "Transmembrane protein 230 [IPR044234]", "Transmembrane protein 230/134 [IPR008590]", "Transmembrane protein 41A/B [IPR045014]", "Transmembrane protein 43 family [IPR012430]", "Transmembrane protein GPR107/GPR108-like [IPR009637]", "Transport protein particle (TRAPP) component [IPR007194]", "Transposase, L1 [IPR004244]", "Treacle protein [IPR017859]", "Tricarboxylate/iron carrier [IPR004686]", "Triosephosphate isomerase [IPR000652]", "Triosephosphate isomerase, bacterial/eukaryotic [IPR022896]", "Tropomodulin [IPR004934]", "Tropomodulin-1 [IPR030135]", "Tropomodulin-3 [IPR030133]", "Tropomyosin [IPR000533]", "Tryptophan-tRNA ligase [IPR002306]", "Tubulin [IPR000217]", "Tubulin binding cofactor A [IPR004226]", "Tubulin--tyrosine ligase-like protein 12 [IPR027749]", "Tubulin-folding cofactor D [IPR033162]", "Tubulin-specific chaperone C [IPR027684]", "Tubulin-specific chaperone E [IPR044994]", "Tubulin-tyrosine ligase/Tubulin polyglutamylase [IPR004344]", "Tumour protein D52 [IPR007327]", "Tweety [IPR006990]", "Twinfilin [IPR028458]", "Type 1 protein exporter [IPR039421]", "Type II pantothenate kinase [IPR004567]", "Type II phosphatidylinositol 4-kinase Lsb6/PI4K2 [IPR039756]", "Tyrosine-tRNA ligase [IPR002307]", "Tyrosine-tRNA ligase, bacterial-type [IPR024088]", "Tyrosine/threonine-protein kinase, Cdc2 inhibitor [IPR016235]", "U1 small nuclear ribonucleoprotein C [IPR017340]", "U2 auxiliary factor small subunit [IPR009145]", "U2 small nuclear ribonucleoprotein A' [IPR044640]", "U2 snRNP auxilliary factor, large subunit, splicing factor [IPR006529]", "U3 small nucleolar RNA-associated protein 10 [IPR040191]", "U3 small nucleolar RNA-associated protein 18 [IPR045161]", "U3 small nucleolar RNA-associated protein 25 [IPR010678]", "U3 small nucleolar RNA-associated protein 6 [IPR013949]", "U3 small nucleolar ribonucleoprotein complex, subunit Mpp10 [IPR012173]", "U4/U6 small nuclear ribonucleoprotein Prp3 [IPR027104]", "U4/U6 small nuclear ribonucleoprotein Prp31 [IPR027105]", "U6 snRNA-associated Sm-like protein Lsm1/8 [IPR044642]", "UAA transporter [IPR013657]", "UBAP2/protein lingerer [IPR022166]", "UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110kDa subunit [IPR037919]", "UDP-glucose 6-dehydrogenase, eukaryotic type [IPR028356]", "UDP-glucose/GDP-mannose dehydrogenase [IPR017476]", "UDP-glucose:Glycoprotein Glucosyltransferase [IPR009448]", "UDP-sugar pyrophosphorylase [IPR039741]", "UDPGP family [IPR002618]", "UHRF1/2-like [IPR045134]", "UMP-CMP kinase [IPR006266]", "USP39 [IPR033809]", "UTP--glucose-1-phosphate uridylyltransferase [IPR016267]", "UV excision repair protein Rad23 [IPR004806]", "Ubiquinol-cytochrome c chaperone, CBP3 [IPR007129]", "Ubiquinol-cytochrome c chaperone/UPF0174 [IPR021150]", "Ubiquinone biosynthesis protein COQ9 [IPR012762]", "Ubiquitin binding protein, Hrs/VPS27 [IPR017073]", "Ubiquitin carboxyl-terminal hydrolase 10 [IPR028767]", "Ubiquitin carboxyl-terminal hydrolase 14-like [IPR044635]", "Ubiquitin conjugation factor E4 [IPR045132]", "Ubiquitin domain-containing protein UBFD1 [IPR039120]", "Ubiquitin fusion degradation protein Ufd1-like [IPR004854]", "Ubiquitin thioesterase OTUB1 [IPR030298]", "Ubiquitin thioesterase Otubain [IPR016615]", "Ubiquitin-activating enzyme E1 [IPR018075]", "Ubiquitin-fold modifier 1 [IPR005375]", "Ubiquitin-fold modifier-conjugating enzyme 1 [IPR014806]", "Ubiquitin-like modifier-activating enzyme Atg7 [IPR006285]", "Ubiquitin-protein ligase E3A [IPR017134]", "Ubiquitin/SUMO-activating enzyme E1 [IPR000011]", "Ubiquitinyl hydrolase [IPR016652]", "Ubiquitinyl hydrolase, UCH37 type [IPR017390]", "Uncharacterised conserved protein UCP013899, metal binding [IPR016617]", "Uncharacterized protein KIAA2013-like [IPR018795]", "Uracil-DNA glycosylase family 1 [IPR002043]", "Uroporphyrinogen decarboxylase HemE [IPR006361]", "V-type ATPase, V0 complex, 116kDa subunit family [IPR002490]", "V-type ATP synthase catalytic alpha chain [IPR022878]", "V-type ATP synthase regulatory subunit B/beta [IPR022879]", "V-type ATPase subunit E [IPR002842]", "V0 complex accessory subunit Ac45 [IPR008388]", "VPRBP/DCAF1 family [IPR033270]", "Vacuolar protein sorting protein 26 related [IPR028934]", "Vacuolar protein sorting-associated protein 29 [IPR028661]", "Vacuolar protein sorting-associated protein 33 [IPR027121]", "Vacuolar protein sorting-associated protein 35 [IPR005378]", "Vacuolar protein sorting-associated protein 4 [IPR031255]", "Vacuolar protein sorting-associated protein 9-like [IPR045046]", "Vacuolar protein sorting-associated protein Ist1 [IPR005061]", "Vacuolar protein sorting-associated protein Vta1-like [IPR044538]", "Vacuolar protein-sorting protein Bro1-like [IPR045251]", "Valine-tRNA ligase [IPR002303]", "Vang-like protein [IPR009539]", "Vesicle transport protein, Got1/SFT2-like [IPR007305]", "Vesicle-associated membrane-protein-associated protein [IPR016763]", "Vesicle-fusing ATPase [IPR039812]", "Vesicle-trafficking protein Sec22 [IPR044565]", "Villin/Gelsolin [IPR007122]", "Vimentin [IPR027699]", "Vinculin [IPR017997]", "Vinculin/alpha-catenin [IPR006077]", "Vitamin K epoxide reductase complex subunit 1 [IPR042406]", "Vitamin K-dependent gamma-carboxylase [IPR007782]", "Voltage-dependent anion-selective channel protein 1 [IPR030270]", "Voltage-dependent anion-selective channel protein 2 [IPR030277]", "Voltage-dependent anion-selective channel protein 3 [IPR030271]", "Vps52 [IPR007258]", "WASH complex subunit 7 [IPR027307]", "WD repeat BOP1/Erb1 [IPR028598]", "WD repeat Prp46/PLRG1-like [IPR045241]", "WD repeat domain phosphoinositide-interacting protein 2 [IPR032911]", "WD repeat-containing protein 41 [IPR040102]", "WD repeat-containing protein 91 [IPR039724]", "WD repeat-containing protein DCAF7-like [IPR045159]", "WD repeat-containing protein WDR18/Ipi3/RID3 [IPR045227]", "WD repeat-containing protein WDR46/Utp7 [IPR040315]", "WD40 repeat-containing protein SMU1 [IPR045184]", "WW domain binding protein 11 [IPR019007]", "WW domain-binding protein 2 [IPR033598]", "WW domain-binding protein 2-like [IPR044852]", "Wings apart-like protein [IPR039874]", "Wolframin [IPR026208]", "Wolframin family [IPR026209]", "XAP5 protein [IPR007005]", "XMAP215 family [IPR045110]", "XPG/Rad2 endonuclease [IPR006084]", "Xaa-Arg dipeptidase [IPR017144]", "YAP-binding/ALF4/Glomulin [IPR013877]", "YEATS [IPR005033]", "YLP motif-containing protein 1 [IPR026314]", "YTH domain containing protein [IPR045168]", "YgfZ/GcvT [IPR045179]", "YjeF N-terminal domain-containing protein NAXE-like [IPR032976]", "YjgF/YER057c/UK114 family [IPR006175]", "ZPR1 family [IPR040141]", "Zinc finger CCCH domain-containing protein A/B [IPR039691]", "Zinc finger CCHC domain-containing protein 3 [IPR042509]", "Zinc finger FYVE domain containing protein, SARA/endofin [IPR035438]", "Zinc finger FYVE domain-containing protein, endofin [IPR017165]", "Zinc finger protein 622/Rei1/Reh1 [IPR040025]", "Zinc finger protein 638 [IPR033096]", "cAMP-dependent protein kinase catalytic subunit [IPR044109]", "cAMP-dependent protein kinase regulatory subunit [IPR012198]", "dCTP pyrophosphatase 1 [IPR025984]", "dTDP-4-dehydrorhamnose reductase family [IPR005913]", "hnRNP A2/B1 [IPR034489]", "mRNA 3'-end-processing protein Rna14-like [IPR045243]", "mRNA export factor Gle2/RAE1 [IPR037631]", "mRNA-decapping enzyme subunit 1 [IPR010334]", "p53 tumour suppressor family [IPR002117]", "rRNA biogenesis protein Rrp5 [IPR045209]", "tRNA (C5-cytosine) methyltransferase, NCL1 [IPR023270]", "tRNA (cytidine(32)/guanosine(34)-2-O)-methyltransferase, Trm7 [IPR028590]", "tRNA (guanine-N1-)-methyltransferase, eukaryotic [IPR007356]", "tRNA N6-adenosine threonylcarbamoyltransferase Kae1, archaea and eukaryote [IPR034680]", "tRNA methyltransferase 10 homologue C [IPR025812]", "tRNA methyltransferase, Trm1 [IPR002905]", "tRNA modification GTPase MnmE [IPR004520]", "tRNA pseudouridine synthase B family [IPR004802]"], "available_proteins": ["AAAS", "AAR2", "AARS", "AARS2", "AATF", "ABCB1", "ABCB10", "ABCB7", "ABCD3", "ABCE1", "ABHD12", "ABHD6", "ACAA2", "ACADM", "ACAT1", "ACAT2", "ACBD5", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT8", "ACOX1", "ACOX3", "ACP1", "ACP2", "ACP6", "ACSL1", "ACTR10", "ACTR1A", "ACTR2", "ACTR3", "ADA", "ADD1", "ADD3", "ADH5", "ADI1", "ADK", "ADNP", "ADPGK", "ADPRHL2", "ADSL", "ADSS", "AFG3L2", "AGL", "AGPS", "AHCY", "AHCYL1", "AHSA1", "AIMP2", "AIP", "AK1", "AK2", "AK4", "AK6", "AKAP12", "AKAP13", "AKAP8", "AKAP8L", "AKR1A1", "AKR1B1", "ALDH18A1", "ALDH3A2", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDOA", "ALDOC", "ALG1", "ALKBH5", "AMOT", "ANAPC1", "ANAPC16", "ANAPC4", "ANAPC5", "ANKLE2", "ANP32A", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP1M1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "APC", "APEX1", "API5", "APOL2", "APOOL", "APP", "APRT", "AQR", "ARCN1", "ARF4", "ARF5", "ARFIP1", "ARFIP2", "ARHGDIA", "ARID1A", "ARID3B", "ARIH1", "ARL1", "ARL2", "ARL3", "ARL6IP1", "ARL6IP5", "ARL8B", "ARMC1", "ARMC6", "ARMC8", "ARMT1", "ARPC1A", "ARPC2", "ARPC3", "ARPC4", "ARPC5", "ASAH1", "ASF1A", "ASNA1", "ASNS", "ASPH", "ATAD3A", "ATAD3B", "ATE1", "ATG7", "ATIC", "ATP13A1", "ATP1A1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5L", "ATP5O", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1D", "ATP6V1E1", "ATP6V1H", "ATPAF1", "ATPIF1", "ATXN2L", "AURKA", "B3GALT6", "B4GAT1", "BABAM1", "BAG2", "BAG4", "BAG5", "BAIAP2", "BAK1", "BANF1", "BAP18", "BASP1", "BCAP31", "BCAS2", "BCAS3", "BCCIP", "BCL2L13", "BCLAF1", "BDH2", "BICD2", "BIRC6", "BLMH", "BLVRA", "BMS1", "BNIP1", "BOP1", "BPNT1", "BPTF", "BRAT1", "BRI3BP", "BRIX1", "BSG", "BTAF1", "BTF3", "BUB1", "BUB1B", "BUD31", "BYSL", "C11orf58", "C12orf43", "C12orf73", "C19orf70", "C1QBP", "C1orf122", "C1orf35", "CAD", "CALD1", "CALR", "CALU", "CAND1", "CANX", "CAP1", "CAPN1", "CAPNS1", "CAPRIN1", "CAPZA1", "CAPZB", "CARM1", "CARS", "CARS2", "CASP3", "CASP6", "CASP7", "CASP8", "CAST", "CBR1", "CBX3", "CCAR1", "CCAR2", "CCDC124", "CCDC134", "CCDC137", "CCDC138", "CCDC22", "CCDC47", "CCDC6", "CCDC86", "CCDC93", "CCDC94", "CCNB1", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2AP", "CD2BP2", "CD3EAP", "CD47", "CDC123", "CDC37", "CDC40", "CDC42", "CDC45", "CDC73", "CDCA5", "CDIPT", "CDK5RAP3", "CDK6", "CDS2", "CDV3", "CEBPZ", "CEP44", "CEP55", "CERS1", "CERS2", "CETN2", "CFAP20", "CFL1", "CFL2", "CGGBP1", "CHAC2", "CHAF1B", "CHAMP1", "CHCHD3", "CHERP", "CHML", "CHMP1A", "CHMP2B", "CHMP5", "CHMP6", "CHMP7", "CHORDC1", "CHST14", "CIAPIN1", "CIP2A", "CISD1", "CISD2", "CIZ1", "CKAP2", "CKAP4", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLCC1", "CLCN3", "CLGN", "CLIC1", "CLIC4", "CLINT1", "CLN5", "CLNS1A", "CLPB", "CLPP", "CLPTM1", "CLPTM1L", "CLPX", "CLTA", "CLTC", "CLUH", "CMPK1", "CMSS1", "CNDP2", "CNN2", "CNN3", "CNNM3", "CNNM4", "CNOT1", "CNOT7", "CNOT9", "CNP", "CNPY2", "COA3", "COA7", "COASY", "COG2", "COG6", "COIL", "COLGALT1", "COMMD4", "COMT", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS7A", "COPS7B", "COPS8", "COPZ1", "COQ8A", "COQ9", "CORO1B", "CORO1C", "COTL1", "COX15", "COX2", "COX4I1", "COX5A", "COX5B", "COX6C", "COX7A2", "COX7C", "CPD", "CPNE1", "CPNE3", "CPOX", "CPSF2", "CPSF6", "CPSF7", "CPT1A", "CPT2", "CPVL", "CRMP1", "CRNKL1", "CRTAP", "CS", "CSNK2A2", "CSNK2B", "CSTB", "CSTF1", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTPS2", "CTR9", "CTSA", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4A", "CUL4B", "CUL5", "CUTA", "CWF19L1", "CXorf57", "CYB5R3", "CYC1", "CYFIP1", "CYP20A1", "CYP51A1", "DAD1", "DAP3", "DARS", "DARS2", "DBN1", "DBNL", "DCAF1", "DCAF7", "DCAKD", "DCD", "DCP1A", "DCPS", "DCTD", "DCTN2", "DCTN3", "DCTN4", "DCTN6", "DCTPP1", "DCUN1D4", "DCUN1D5", "DCXR", "DDAH1", "DDB1", "DDOST", "DDRGK1", "DDT", "DDX54", "DEK", "DENR", "DERL1", "DFFA", "DHCR24", "DHCR7", "DHFR", "DHPS", "DHRS7B", "DIABLO", "DIAPH1", "DIAPH3", "DIDO1", "DIEXF", "DKC1", "DLAT", "DLD", "DLST", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJC10", "DNAJC2", "DNAJC8", "DNM1L", "DNM2", "DNMT1", "DNPH1", "DNTTIP2", "DOCK7", "DOHH", "DOLPP1", "DPH2", "DPH5", "DPP3", "DPYSL2", "DPYSL3", "DRG1", "DRG2", "DSG2", "DSP", "DST", "DSTN", "DTYMK", "DUSP3", "DUSP9", "DUT", "DYNC1I2", "DYNC1LI1", "DYNLL1", "DYNLL2", "EARS2", "EBNA1BP2", "EBP", "ECD", "ECE1", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "ECSIT", "EDC4", "EEF1A2", "EEF1E1", "EEF1G", "EHD1", "EHD4", "EIF2A", "EIF2B1", "EIF2B2", "EIF2B4", "EIF2D", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4B", "EIF4E", "EIF4G1", "EIF4G2", "EIF4G3", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAVL1", "ELOB", "ELOC", "ELP1", "ELP2", "ELP3", "EMC1", "EMC2", "EMC3", "EMC4", "EMD", "EMG1", "ENDOD1", "ENO1", "ENSA", "EPB41", "EPB41L2", "EPB41L3", "EPHX1", "EPHX2", "EPPK1", "EPRS", "ERAL1", "ERAP1", "ERCC2", "ERCC3", "ERGIC2", "ERGIC3", "ERH", "ERLIN1", "ERLIN2", "ERMP1", "ERO1A", "ERP29", "ESD", "ESF1", "ETF1", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXO1", "EXOC2", "EXOC4", "EXOC5", "EXOC7", "EXOSC10", "EXOSC3", "EXOSC8", "EZR", "F11R", "FABP5", "FADS2", "FAH", "FAM114A2", "FAM120A", "FAM162A", "FAM213A", "FAM3C", "FAM49B", "FAM50A", "FAM8A1", "FAM91A1", "FAM98A", "FAM98B", "FANCI", "FAR1", "FARSA", "FARSB", "FAU", "FBL", "FDFT1", "FDPS", "FDX1", "FDXR", "FECH", "FEN1", "FERMT2", "FH", "FHL1", "FHOD1", "FIS1", "FKBP3", "FKBP4", "FKBP5", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FMR1", "FN3KRP", "FNTB", "FOXC1", "FRYL", "FSCN1", "FTO", "FTSJ1", "FTSJ3", "FUCA1", "FUCA2", "FUNDC2", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GADD45GIP1", "GALK1", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GATAD2B", "GATB", "GATC", "GBA", "GBE1", "GCAT", "GCLM", "GCN1", "GDAP1", "GDI1", "GDI2", "GEMIN4", "GET4", "GFM1", "GFPT1", "GGCT", "GGCX", "GGH", "GHDC", "GHITM", "GINS2", "GINS3", "GINS4", "GLA", "GLB1", "GLDC", "GLG1", "GLMN", "GLO1", "GLOD4", "GLRX3", "GLRX5", "GLS", "GLUD1", "GM2A", "GMDS", "GMFB", "GNA13", "GNAI1", "GNAI2", "GNAI3", "GNL1", "GNL2", "GNPDA1", "GNS", "GOLGA3", "GOLGB1", "GOLIM4", "GOLPH3", "GOLT1B", "GORASP2", "GOT1", "GOT2", "GPAM", "GPD2", "GPHN", "GPI", "GPKOW", "GPR107", "GPR108", "GPR89B", "GPS1", "GPT2", "GPX8", "GRPEL1", "GRSF1", "GSK3B", "GSR", "GSS", "GSTK1", "GSTM3", "GSTO1", "GSTZ1", "GTF2B", "GTF2E1", "GTF2F1", "GTF2F2", "GTF2I", "GTF3C1", "GTF3C3", "GTPBP1", "GTPBP10", "GTPBP3", "GTPBP4", "GUSB", "GYG1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACD3", "HADH", "HADHA", "HADHB", "HAT1", "HAUS4", "HAUS5", "HCCS", "HCFC1", "HDAC2", "HDHD2", "HDHD3", "HDHD5", "HEATR1", "HEBP1", "HECTD1", "HEXA", "HEXB", "HGH1", "HGS", "HIBADH", "HIBCH", "HINT2", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLCS", "HM13", "HMBS", "HMGA1", "HMGB1", "HMGB3", "HMGCL", "HMGCS1", "HMOX1", "HMOX2", "HNRNPA1", "HNRNPA2B1", "HNRNPC", "HNRNPK", "HNRNPL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HP1BP3", "HPRT1", "HS2ST1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSDL1", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA14", "HSPA1B", "HSPA2", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPB1", "HSPD1", "HSPE1", "HSPH1", "HTATSF1", "HTT", "HUS1", "HYOU1", "IARS", "IARS2", "IBA57", "ICMT", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDI1", "IFIT5", "IFT27", "IGBP1", "IGF2BP2", "IK", "IKBIP", "ILF3", "ILKAP", "ILVBL", "IMMT", "IMP3", "IMPDH1", "IMPDH2", "INA", "INF2", "INTS13", "INTS14", "INTS3", "INTS7", "IPO4", "IPO5", "IRGQ", "IRS4", "IST1", "ISYNA1", "ITCH", "ITGB1", "ITPA", "IVD", "JPT2", "JUP", "KARS", "KDELR1", "KDM1A", "KDM3B", "KDSR", "KHDRBS1", "KHDRBS3", "KIAA0319L", "KIAA0368", "KIAA1468", "KIAA2013", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF3A", "KIF5B", "KIFBP", "KLC1", "KLC2", "KLC4", "KPNA1", "KPNA2", "KPNA3", "KPNA6", "KPNB1", "KRI1", "KTN1", "KYAT3", "L1RE1", "LAMP1", "LAMP2", "LAMTOR1", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LAS1L", "LBR", "LDHA", "LDHB", "LEMD2", "LEMD3", "LENG8", "LETM1", "LGALS3", "LGMN", "LIG1", "LIG3", "LIMA1", "LIPA", "LLGL1", "LMAN1", "LNPEP", "LNPK", "LONP1", "LPP", "LRPAP1", "LRPPRC", "LRRC47", "LSM12", "LSM6", "LSM7", "LSM8", "LSS", "LTA4H", "LTV1", "LUC7L2", "LYAR", "LZIC", "LZTFL1", "M6PR", "MACF1", "MAD1L1", "MAD2L1", "MAGED2", "MAGT1", "MAK16", "MAP1B", "MAP1S", "MAP4", "MAPK1", "MAPK14", "MAPRE1", "MAPRE2", "MARCKS", "MARS", "MARS2", "MAT2A", "MAT2B", "MAU2", "MAVS", "MBOAT7", "MCCC2", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCMBP", "MCTS1", "MCU", "MCUR1", "MDH1", "MDH2", "MDN1", "ME2", "MEAF6", "MECP2", "MED24", "MESD", "METAP1", "MFAP1", "MFN1", "MFN2", "MFSD5", "MGEA5", "MGST2", "MGST3", "MICU1", "MICU2", "MID1", "MIF", "MIGA1", "MINPP1", "MIOS", "MIPEP", "MLEC", "MMAB", "MMS19", "MOGS", "MON2", "MORF4L1", "MOV10", "MPDU1", "MPHOSPH10", "MPI", "MPST", "MPV17L2", "MRE11", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL14", "MRPL15", "MRPL17", "MRPL19", "MRPL20", "MRPL21", "MRPL37", "MRPL38", "MRPL40", "MRPL43", "MRPL44", "MRPL47", "MRPL48", "MRPL49", "MRPL50", "MRPL53", "MRPL9", "MRPS15", "MRPS17", "MRPS2", "MRPS22", "MRPS23", "MRPS25", "MRPS27", "MRPS30", "MRPS31", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRPS9", "MRTO4", "MSH2", "MSH3", "MSH6", "MSN", "MTA1", "MTA2", "MTAP", "MTBP", "MTDH", "MTFP1", "MTHFD1", "MTHFD1L", "MTHFD2", "MTOR", "MTR", "MTX1", "MTX2", "MXRA7", "MYBBP1A", "MYCBP", "MYDGF", "MYEF2", "MYG1", "NAA10", "NAA15", "NAA25", "NAA35", "NAA40", "NADK2", "NAE1", "NAF1", "NAGK", "NAGLU", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NAPG", "NARS", "NAT10", "NAXE", "NBN", "NCAPD2", "NCAPG", "NCAPH", "NCBP1", "NCBP2", "NCDN", "NCKAP1", "NCLN", "NCSTN", "NDC1", "NDRG3", "NDUFA13", "NDUFA4", "NDUFAF7", "NDUFB10", "NDUFB11", "NDUFB4", "NDUFB5", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS7", "NDUFS8", "NDUFV1", "NDUFV2", "NEFL", "NEFM", "NELFCD", "NELFE", "NES", "NFKB1", "NFS1", "NHP2", "NIP7", "NLN", "NMD3", "NME1", "NME2", "NMT1", "NNT", "NOC2L", "NOC3L", "NOC4L", "NOL10", "NOL11", "NOL6", "NOL7", "NOL9", "NOP10", "NOP14", "NOP16", "NOP2", "NOP56", "NOP58", "NOP9", "NOSIP", "NPC1", "NPEPPS", "NPLOC4", "NPM1", "NSA2", "NSF", "NSUN2", "NSUN5", "NT5C2", "NT5C3B", "NT5DC1", "NT5DC2", "NTMT1", "NTPCR", "NUB1", "NUBP2", "NUBPL", "NUCB1", "NUCB2", "NUCKS1", "NUDC", "NUDCD1", "NUDCD2", "NUDT1", "NUDT21", "NUDT9", "NUFIP2", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP160", "NUP188", "NUP205", "NUP210", "NUP214", "NUP35", "NUP37", "NUP50", "NUP54", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NUTF2", "NXF1", "OAT", "OCIAD1", "OCLN", "OGDH", "OGT", "OLA1", "OPA1", "OPA3", "OSBP", "OSBPL11", "OSBPL6", "OSBPL8", "OSBPL9", "OSGEP", "OTUB1", "OXA1L", "P3H1", "P3H4", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PACSIN3", "PAF1", "PAFAH1B1", "PAK2", "PANK4", "PAPSS1", "PARK7", "PARN", "PBDC1", "PBRM1", "PC", "PCBD1", "PCID2", "PCK2", "PCLAF", "PCM1", "PCMT1", "PCNA", "PCNP", "PCYOX1", "PDAP1", "PDCD11", "PDCD4", "PDCD5", "PDCD6IP", "PDE6D", "PDHA1", "PDHB", "PDIA3", "PDIA4", "PDIA6", "PDK3", "PDLIM1", "PDS5A", "PDS5B", "PDXK", "PEBP1", "PECR", "PELO", "PES1", "PEX11G", "PEX14", "PEX19", "PEX5", "PFAS", "PFDN2", "PFDN4", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGP", "PHB", "PHB2", "PHF5A", "PHGDH", "PI4K2A", "PI4KB", "PICALM", "PIGK", "PIGS", "PIK3C3", "PIN4", "PIP4K2C", "PIR", "PISD", "PITHD1", "PITPNA", "PITPNB", "PKM", "PKMYT1", "PLA2G15", "PLBD2", "PLCG1", "PLEC", "PLIN3", "PLRG1", "PLS3", "PM20D2", "PMPCA", "PMPCB", "PNN", "PNO1", "PNP", "PNPT1", "POFUT1", "POLA1", "POLA2", "POLD1", "POLE", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2A", "POLR2B", "POLR2E", "POLR2G", "POLR2L", "POLR3A", "POLRMT", "PON2", "POP1", "POR", "PPA1", "PPA2", "PPAN", "PPAT", "PPFIA1", "PPIE", "PPIH", "PPIL1", "PPIL4", "PPM1G", "PPME1", "PPOX", "PPP1CA", "PPP1R12A", "PPP2R1A", "PPP2R2A", "PPP2R5D", "PPP5C", "PPT1", "PPT2", "PRAF2", "PRC1", "PRCC", "PRCP", "PRDX2", "PRDX5", "PRDX6", "PREB", "PREP", "PREPL", "PRIM1", "PRIM2", "PRKACA", "PRKAG1", "PRKAR1A", "PRKAR2A", "PRKCSH", "PRKRA", "PRMT1", "PRMT3", "PRMT5", "PRMT9", "PRPF19", "PRPF3", "PRPF31", "PRPF38B", "PRPF40A", "PRPF6", "PRPF8", "PRPS2", "PRPSAP1", "PRPSAP2", "PRRC1", "PRRC2A", "PRRC2C", "PSAP", "PSAT1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD6", "PSMD7", "PSMD8", "PSME1", "PSME2", "PSME3", "PSME4", "PSMF1", "PSMG1", "PSMG3", "PTBP1", "PTBP2", "PTCD3", "PTDSS1", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTPA", "PTPN1", "PTRH2", "PTRHD1", "PUF60", "PUM3", "PURA", "PUS7", "PWP1", "PWP2", "PXMP2", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QDPR", "QKI", "QRSL1", "RAB10", "RAB11B", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB1B", "RAB24", "RAB34", "RAB3GAP1", "RAB3GAP2", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RAB8A", "RAB8B", "RAB9A", "RABEP1", "RABGAP1", "RAC1", "RACK1", "RAD21", "RAD23A", "RAD23B", "RAD50", "RAD9A", "RAE1", "RAI14", "RALA", "RALB", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RAP1GDS1", "RAPGEF2", "RARS", "RARS2", "RAVER1", "RBBP5", "RBBP6", "RBM10", "RBM17", "RBM22", "RBM26", "RBM27", "RBM39", "RBM5", "RBM8A", "RCC2", "RCL1", "RDH11", "RDH13", "RDH14", "RDX", "RECQL", "REEP5", "REPS1", "RER1", "REXO2", "REXO4", "RFC1", "RFX1", "RHEB", "RHOA", "RHOG", "RHOT1", "RIC8A", "RIDA", "RIF1", "RINT1", "RIOX2", "RNASEH2A", "RNASET2", "RNF14", "RNF20", "RNF219", "RNF40", "RNPEP", "ROCK2", "RP2", "RPA1", "RPA2", "RPAP1", "RPF2", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPN1", "RPN2", "RPP30", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RRBP1", "RRM1", "RRM2", "RRP1", "RRP15", "RRP1B", "RRP8", "RRS1", "RSF1", "RSL1D1", "RTCB", "RTN4IP1", "RTRAF", "RUVBL1", "RUVBL2", "S100A10", "S100A11", "S100A13", "SAE1", "SAFB", "SAFB2", "SAMM50", "SAP130", "SAP18", "SAR1A", "SARS", "SARS2", "SART1", "SBDS", "SCAF1", "SCAMP1", "SCAMP2", "SCAMP3", "SCARB1", "SCARB2", "SCD", "SCFD1", "SCO1", "SCO2", "SCPEP1", "SCRN1", "SDF4", "SDHA", "SDHB", "SEC11A", "SEC16A", "SEC22B", "SEC23A", "SEC23B", "SEC31A", "SEC61A1", "SEC61B", "SEC62", "SEC63", "SEH1L", "SENP3", "SEPHS1", "SEPT11", "SEPT2", "SEPT7", "SEPT9", "SERBP1", "SERPINB6", "SERPINH1", "SET", "SETD2", "SF1", "SF3A1", "SF3A3", "SF3B1", "SFSWAP", "SFXN1", "SFXN4", "SGPL1", "SH3BGRL3", "SH3GL1", "SH3GLB1", "SHCBP1", "SHMT1", "SHMT2", "SHOC2", "SHTN1", "SIGMAR1", "SIRT1", "SKIV2L", "SKIV2L2", "SKP1", "SLAIN1", "SLC16A1", "SLC19A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A12", "SLC25A13", "SLC25A17", "SLC25A22", "SLC25A24", "SLC25A3", "SLC25A32", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A4", "SLC29A1", "SLC2A1", "SLC33A1", "SLC35A4", "SLC35B2", "SLC35F2", "SLC3A2", "SLC7A1", "SLC9A3R1", "SLFN11", "SLK", "SLTM", "SMARCA4", "SMARCC1", "SMARCC2", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMCHD1", "SMPD4", "SMU1", "SMYD3", "SND1", "SNRPA1", "SNRPC", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNU13", "SNW1", "SNX1", "SNX17", "SNX2", "SNX27", "SNX5", "SNX6", "SNX9", "SOAT1", "SOD2", "SON", "SORD", "SPAG9", "SPART", "SPC24", "SPC25", "SPCS2", "SPECC1L", "SPOUT1", "SPPL2A", "SPR", "SPTBN1", "SPTBN2", "SQLE", "SRM", "SRP14", "SRP54", "SRP68", "SRP72", "SRP9", "SRPRB", "SRRT", "SRSF10", "SRSF11", "SRSF6", "SSB", "SSBP1", "SSNA1", "SSR1", "SSR4", "SSRP1", "STAG1", "STAG2", "STARD3", "STAT1", "STAT3", "STIP1", "STMN1", "STOM", "STOML2", "STRBP", "STT3A", "STUB1", "STX12", "STX5", "STX7", "STXBP3", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGP2", "SUGT1", "SUN1", "SUPT16H", "SUPT5H", "SUPT6H", "SURF4", "SURF6", "SV2A", "SYMPK", "SYNCRIP", "SYNE2", "SYNGR2", "TACC3", "TAF15", "TAGLN2", "TALDO1", "TAMM41", "TARS", "TARS2", "TBCA", "TBCC", "TBCD", "TBCE", "TCEA1", "TCERG1", "TCOF1", "TCP1", "TECR", "TERF2IP", "TEX10", "TFG", "TFRC", "THOC1", "THOC2", "THOC3", "THOC6", "THOP1", "THRAP3", "THUMPD1", "TIGAR", "TIMM10", "TIMM17A", "TIMM17B", "TIMM23", "TIMM44", "TIMM50", "TIMM8B", "TIPRL", "TJP1", "TK1", "TKFC", "TM9SF3", "TMA16", "TMCO1", "TMED10", "TMED2", "TMED5", "TMED7", "TMED9", "TMEM109", "TMEM126A", "TMEM14C", "TMEM160", "TMEM165", "TMEM192", "TMEM199", "TMEM201", "TMEM205", "TMEM209", "TMEM214", "TMEM230", "TMEM33", "TMEM41A", "TMEM43", "TMEM97", "TMOD1", "TMOD3", "TMX2", "TNKS1BP1", "TNPO1", "TNPO2", "TOE1", "TOMM20", "TOMM22", "TOMM40", "TOMM5", "TOP1", "TOP2A", "TOP2B", "TOR1AIP1", "TOX4", "TP53", "TPD52", "TPD52L2", "TPI1", "TPM1", "TPM3", "TPM4", "TPP2", "TPT1", "TPX2", "TRABD", "TRAM1", "TRAP1", "TRAPPC5", "TRIM28", "TRIP12", "TRIP13", "TRIR", "TRMT10C", "TRMT1L", "TROVE2", "TSFM", "TSN", "TSNAX", "TSPAN3", "TSPAN6", "TSR1", "TTC19", "TTC26", "TTC37", "TTC38", "TTLL12", "TTYH3", "TUBB", "TUBB2A", "TUBB2B", "TUBB4A", "TUBB4B", "TUBB6", "TUBGCP2", "TUBGCP3", "TUFM", "TWF1", "TWF2", "TXLNA", "TXLNG", "TXNDC12", "TXNDC17", "TXNRD1", "TYMS", "U2AF1", "U2AF2", "UAP1", "UBA1", "UBA2", "UBA3", "UBA6", "UBAP2", "UBAP2L", "UBE3A", "UBE4B", "UBFD1", "UBR4", "UCHL5", "UFC1", "UFD1", "UFL1", "UFM1", "UGDH", "UGGT1", "UGP2", "UHRF1", "UMPS", "UNC119", "UNG", "UPF1", "UQCC1", "UQCR10", "UQCRB", "UQCRQ", "URB1", "UROD", "USMG5", "USP10", "USP14", "USP39", "USP5", "USP9X", "UTP11", "UTP14A", "UTP18", "UTP3", "UTP6", "UTRN", "VAMP7", "VANGL1", "VAPA", "VAPB", "VARS1", "VARS2", "VBP1", "VCL", "VCP", "VDAC1", "VDAC2", "VDAC3", "VIM", "VIPAS39", "VIRMA", "VKORC1L1", "VPS26A", "VPS29", "VPS33A", "VPS33B", "VPS35", "VPS4B", "VPS52", "VTA1", "WAPL", "WARS", "WASHC4", "WBP11", "WBP2", "WDR18", "WDR41", "WDR46", "WDR82", "WDR91", "WFS1", "WIPI2", "WTAP", "XAB2", "XPO1", "XPO5", "XPO7", "XPOT", "XRCC5", "XRCC6", "XRN2", "YARS", "YARS2", "YEATS4", "YLPM1", "YME1L1", "YTHDC1", "YTHDC2", "YTHDF2", "YTHDF3", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZC3H14", "ZC3H7A", "ZCCHC3", "ZFYVE16", "ZMPSTE24", "ZNF326", "ZNF622", "ZNF638", "ZPR1", "ZW10"], "leading_proteins": ["ABCB1", "ACOX3", "AK4", "AKAP8L", "ARIH1", "ATAD3B", "ATP13A1", "ATP6V0A2", "BCLAF1", "BUB1", "CARM1", "CASP7", "CHST14", "CLPTM1", "CNOT7", "COASY", "COPG1", "COPS7B", "CPSF7", "CTPS1", "CYP51A1", "DCUN1D4", "DNAJA2", "DNAJA3", "DNM2", "DRG1", "ECH1", "EIF3M", "ERGIC3", "FLOT1", "FMR1", "FUCA2", "FUS", "GNAI2", "GNAI3", "GPR107", "HM13", "HMOX2", "HNRNPC", "HSDL1", "IMPDH1", "KDSR", "KHDRBS1", "KHDRBS3", "KLC2", "LBR", "LTA4H", "MAPRE1", "MCL1", "MCM2", "MCM3", "MCM5", "MCM6", "MCM7", "MICU2", "MIPEP", "MTA1", "MTX1", "MTX2", "NAP1L4", "NLN", "NPEPPS", "NT5DC2", "NUBP2", "NUCB1", "OPA1", "OSBPL6", "PABPC4", "PARN", "PFDN2", "PFDN4", "PITPNB", "PPT1", "PREP", "PRMT9", "PRRC2A", "PSMB2", "PSMB4", "PSMB6", "PSMB7", "PSMD6", "PXMP2", "RAD23A", "RARS2", "RPL27A", "SCAMP1", "SCARB1", "SCO2", "SEC23A", "SET", "SFXN4", "SKP1", "SLC25A1", "SLC25A13", "SLC25A32", "SLC25A5", "SLC25A6", "SLC2A1", "SNX5", "STX5", "STX7", "SV2A", "SYNCRIP", "TAF15", "TIMM17A", "TPD52", "TSPAN3", "TUBGCP2", "VBP1", "VDAC1", "VDAC2", "VDAC3", "YME1L1", "YTHDC1", "YTHDF2", "ZNF326"]} \ No newline at end of file diff --git a/interpro_homologous_superfamily/advanced/idx2term.json 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b/interpro_homologous_superfamily/df_merge.tsv @@ -0,0 +1,6 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Mitochondrial carrier domain superfamily [IPR023395] 6 19 2.8776718101364187 0.0040062168704588 9.148058252427184 20.71359223300971 2.0411027534642088 0.1411881998864352 5.368907349966936 1.8276489510009888 1.309103123363054 0.2428184236965967 5.775152660265721e-05 0.0142466262053111 0.0058560324261939 0.000273959679835 0.0004032504678998 +Nucleotide-binding alpha-beta plait domain superfamily [IPR012677] 48 123 2.327344406710792 0.0199469420732991 41.78155339805825 126.65533980582524 0.1165973051667422 0.543214063567699 13.579176287791377 6.87987395678373 1.6323826073741117 0.3875195330163939 0.0038887667591438 1.0 0.8634038105452405 7.897612567252617e-06 3.893254203190542e-11 +RNA-binding domain superfamily [IPR035979] 49 125 2.3095468818420715 0.0209132532978713 42.40291262135922 128.71601941747574 0.0615554024640467 0.5527296641044032 14.098054374547743 6.713949807605091 1.6556654950344032 0.3906506493803742 0.0036235275721569 1.0 0.8606572512943966 6.9135470329020896e-06 2.912040587428157e-11 +Peptidase M4/M1, CTD superfamily [IPR027268] 2 5 1.982702643867416 0.0474006541036418 2.111650485436894 5.548543689320389 1.4203309343737989 0.1835434124596617 1.027373025804284 0.6683357213562342 0.9844971330203006 0.2264468231852968 0.0004627741362225 0.0007972103198291 0.0032139762811053 0.0010588751859522 0.0077568745967145 +Aminopeptidase N-like , N-terminal domain superfamliy [IPR042097] 2 5 1.982702643867416 0.0474006541036418 2.111650485436894 5.548543689320389 1.4203309343737989 0.1835434124596617 1.027373025804284 0.6683357213562342 0.9844971330203006 0.2264468231852968 0.0004627741362225 0.0007972103198291 0.0032139762811053 0.0010588751859522 0.0077568745967145 diff --git a/interpro_homologous_superfamily/metrics.json b/interpro_homologous_superfamily/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..41693d97b9a2b2af5c99d69245ae8e9ae40d8d3c --- /dev/null +++ b/interpro_homologous_superfamily/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2734, + "annotations_size": 908, + "title": "Average number of proteins per term", + "value": 4.491189427312776 +} \ No newline at end of file diff --git a/interpro_homologous_superfamily/paths.json b/interpro_homologous_superfamily/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..63766ff36137493cd9ef5e0af3217da421f5ca56 --- /dev/null +++ b/interpro_homologous_superfamily/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/interpro_homologous_superfamily/fragment/C166/C166_val_log2fc"} \ No newline at end of file diff --git a/interpro_homologous_superfamily/result.tsv b/interpro_homologous_superfamily/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..e3c896402c616c55712436742951589f86189099 --- /dev/null +++ b/interpro_homologous_superfamily/result.tsv @@ -0,0 +1,100 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Cytochrome P450 superfamily [IPR036396] 0.9707174231332374 3.2947661580401117 0.0009850361243994 0.5913325788341863 0.0048086709728749 2 Q16850 1 +Haem oxygenase-like, multi-helical [IPR016084] 0.9344802342606168 3.1344566453683047 0.0017217269368705 0.790844109488422 0.0073160660261415 2 P30519 1 +Tetraspanin, EC2 domain superfamily [IPR008952] 0.9213030746705726 3.075395732778736 0.002102234182352 0.8520436315382929 0.0085597696752269 2 O60637 1 +Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid [IPR008930] 0.9139824304538824 3.0424043680810593 0.0023469637908797 0.8815835679915028 0.0092872195196187 2 P48449 1 +Regulatory factor, effector binding domain superfamily [IPR011256] 0.901903367496343 2.9876852506745735 0.0028109888026841 0.9223832420752326 0.0105036124808115 2 Q9Y6I9 1 +DCN1-like, PONY binding domain [IPR042460] 0.8920204978038082 2.9426504424856192 0.003254156293456 0.9481599373253332 0.0118190956578323 2 Q92564 1 +Mitochondrial carrier domain superfamily [IPR023395] 0.6974447357963988 2.8776718101364187 0.0040062168704588 0.9738773110899908 0.0135733019342412 19 Q70HW3,Q9NZJ7,O43772,Q9UBX3,Q9H2D1,Q02978 6 +GMP phosphodiesterase, delta subunit superfamily [IPR037036] 0.9835225192237278 2.8576574323671364 0.0042678086510765 0.9794205670212902 0.0142469494675644 3 A6NIH7,O43924 2 +Gamma-tubulin complex component, C-terminal domain superfamily [IPR042241] 0.8111273792093757 2.564855321067748 0.0103218834425529 0.9999189930292744 0.0275655004877589 2 Q9BSJ2 1 +L27 domain superfamily [IPR036892] 0.9025997803002564 2.5185671380792853 0.0117833416712702 0.9999788275647268 0.0300541411166106 3 O14936,Q14168 2 +Ribokinase-like [IPR029056] 0.875362752936901 2.401424812268385 0.0163313648544363 0.99999967883214 0.0373229498222213 3 P55263 1 +AF1104-like superfamily [IPR036075] 0.7730600292825749 2.38128552211654 0.0172523340036638 0.9999998627996824 0.039162798188317 2 Q9H993 1 +Nucleotide-binding alpha-beta plait domain superfamily [IPR012677] 0.3875522684189163 2.327344406710792 0.0199469420732991 0.9999999886596626 0.0442591683471296 123 Q12849,P52272,O60506,Q9Y6M1,P98175,Q01844,O43390,Q9BQ04,Q9UHX1,Q9P2K5,P23246,P84103,Q99729,P35637,P08621,P52597,P23588,P14866,Q14103,Q13151,P55795,P09651,P62995,Q96PK6,O95453,Q96EP5,P22626,P51991,P38159,Q92804,P31942,Q9BWF3,O43347,Q9P2N5,Q93062,O14979,Q13242,Q07955,Q01085,P31943,Q15287,P98179,P43243,P07910,Q8IY67,Q13595,Q15233,P31483 48 +RNA-binding domain superfamily [IPR035979] 0.3857899774966375 2.3095468818420715 0.0209132532978713 0.9999999953695412 0.0459787748050051 125 Q12849,P52272,O60506,Q9Y6M1,P98175,Q01844,O43390,Q9BQ04,Q9UHX1,Q9P2K5,Q71RC2,P23246,P84103,Q99729,P35637,P08621,P52597,P23588,P14866,Q14103,Q13151,P55795,P09651,P62995,Q96PK6,O95453,Q96EP5,P22626,P51991,P38159,Q92804,P31942,Q9BWF3,O43347,Q9P2N5,Q93062,O14979,Q13242,Q07955,Q01085,P31943,Q15287,P98179,P43243,P07910,Q8IY67,Q13595,Q15233,P31483 49 +Rhodanese-like domain superfamily [IPR036873] 0.7320644216691127 2.1794286514299968 0.0292998396175208 0.9999999999981238 0.0597063456685742 2 Q99956 1 +NAP-like superfamily [IPR037231] 0.8246063712925668 2.179061151330385 0.0293271257358855 0.9999999999981712 0.0597063456685742 3 Q01105,Q99733 2 +Neurolysin/Thimet oligopeptidase, N-terminal [IPR024080] 0.7152269399707163 2.095291206174903 0.0361451137183603 0.999999999999997 0.0698292835239813 2 Q9BYT8 1 +CRIB domain superfamily [IPR036936] 0.7119326500732116 2.0787473694786316 0.0376405766140859 0.9999999999999992 0.0719529338222947 2 Q13153 1 +Peptidase M41-like [IPR037219] 0.7112005856515367 2.07506734646775 0.0379802935448947 0.9999999999999994 0.0724498036528664 2 Q96TA2 1 +GTP-binding protein TrmE/Aminomethyltransferase GcvT, domain 1 [IPR027266] 0.7086383601756974 2.062176951689606 0.0391908922025818 0.9999999999999998 0.0741361044165507 2 Q5T440 1 +Peptidase M4/M1, CTD superfamily [IPR027268] 0.8708154093864938 1.982702643867416 0.0474006541036418 1.0 0.0859077723075983 5 P09960,P55786 2 +Aminopeptidase N-like , N-terminal domain superfamliy [IPR042097] 0.8708154093864938 1.982702643867416 0.0474006541036418 1.0 0.0859077723075983 5 P09960,P55786 2 +Porin domain superfamily [IPR023614] 0.8681318681318687 1.978886611067617 0.0478287740355178 1.0 0.0863487090570844 4 P21796,P45880,Q9Y277 3 +Fibronectin type II domain superfamily [IPR036943] 0.7617041721048783 1.8963395176793665 0.0579151639631954 1.0 0.1001656550068217 3 Q9UBG0 1 +Kringle-like fold [IPR013806] 0.7617041721048783 1.8963395176793665 0.0579151639631954 1.0 0.1001656550068217 3 Q9UBG0 1 +Ricin B-like lectins [IPR035992] 0.7594287806664226 1.885971679845468 0.0592987710719561 1.0 0.1019681296995999 3 Q86SF2,Q9UBG0 2 +Class II aldolase/adducin N-terminal domain superfamily [IPR036409] 0.6676427525622284 1.8538154971582328 0.0637655605886826 1.0 0.1078196071033963 2 P35611 1 +EB1, C-terminal domain superfamily [IPR036133] 0.6647144948755506 1.8387863963260735 0.0659466099110703 1.0 0.1102753624295615 2 Q15691 1 +Cytochrome b5-like heme/steroid binding domain superfamily [IPR036400] 0.7889503612266272 1.8035009633005143 0.0713095742925618 1.0 0.117086968277841 6 Q8WUJ1,O15173,O43169 3 +SNARE [IPR010989] 0.8150183150183156 1.7602126210195184 0.0783717628469284 1.0 0.1259496648938249 4 O15400,Q13190,Q9UEU0 3 +P-type ATPase, transmembrane domain superfamily [IPR023298] 0.8122437610377673 1.7486779738223428 0.0803466994978006 1.0 0.128215822748687 4 Q9HD20 1 +P-type ATPase, cytoplasmic domain N [IPR023299] 0.8122437610377673 1.7486779738223428 0.0803466994978006 1.0 0.128215822748687 4 Q9HD20 1 +P-type ATPase, A domain superfamily [IPR008250] 0.8122437610377673 1.7486779738223428 0.0803466994978006 1.0 0.128215822748687 4 Q9HD20 1 +Nucleophile aminohydrolases, N-terminal [IPR029055] 0.5361631284459467 1.7461377542044785 0.0807870178080916 1.0 0.1285083274436528 17 Q06203,P20618,P49721,P28066,P28072,Q99436,P60900,P28070,P28074 9 +Immunoglobulin E-set [IPR014756] 0.5717279102660808 1.6887778531229518 0.091262009522834 1.0 0.1421370577130931 14 A6NIH7,O43924 2 +Neurolysin/Thimet oligopeptidase, domain 2 [IPR024077] 0.715488831929696 1.6840112267177387 0.0921794990835893 1.0 0.1430751883211951 3 Q9BYT8,Q99797 2 +MoaB/Mog-like domain superfamily [IPR036425] 0.62188872620791 1.6170122244966658 0.1058756421838118 1.0 0.1583774021464599 2 Q8NFF5 1 +Arp2/3 complex subunit 2/4 [IPR034666] 0.6153001464128875 1.5826004074431284 0.1135125705873125 1.0 0.1646803904282455 2 O15144 1 +Rho GTPase activation protein [IPR008936] 0.6853203669537938 1.5436452259118278 0.1226743023926171 1.0 0.1759688255489673 3 Q68EM7 1 +PABC (PABP) domain [IPR036053] 0.6847308678139876 1.5408908492290738 0.1233433533186274 1.0 0.1763712831705727 3 Q13310,O95071 2 +K Homology domain, type 1 superfamily [IPR036612] 0.4772030532075736 1.512514968224005 0.1304029077035742 1.0 0.1850091253044459 22 Q96AE4,O75525,O00425,Q9Y6M1,Q07666,Q06787,Q96I24,Q9NQT5,Q15637,P61978,Q92945,Q8TCS8 12 +Metalloenzyme, LuxS/M16 peptidase-like [IPR011249] 0.6843371833612972 1.4296314884009764 0.1528228131266391 1.0 0.2121760157782696 7 P22695,O43847,Q5JRX3,Q10713 4 +ABC transporter type 1, transmembrane domain superfamily [IPR036640] 0.7313018160454245 1.4082237613508757 0.1590648223953581 1.0 0.2194997853115276 4 P08183,O75027 2 +NAD(P)-binding domain superfamily [IPR036291] 0.3674870841685054 1.388397510616307 0.1650160339981785 1.0 0.2273665536727558 64 Q99536,Q06136,Q8N4Q0,P00367,Q53GQ0,Q8NBX0,Q9BY49,P30043,Q13363,Q3SXM5,P40939,O43865,Q16836,Q8WWV3 14 +Heat shock protein DnaJ, cysteine-rich domain superfamily [IPR036410] 0.6481142438667156 1.369140279736282 0.1709554294721667 1.0 0.233776400543264 3 O60884,Q96EY1 2 +PapD-like superfamily [IPR008962] 0.6430499427580569 1.3453081220774858 0.1785257517466276 1.0 0.2421277739602864 3 Q9P0L0 1 +Metallopeptidase, catalytic domain superfamily [IPR024079] 0.7157509157509166 1.3421618171902228 0.1795435338566897 1.0 0.2429590592278305 4 Q9BYT8,P42892,Q99797 3 +Zinc finger, RanBP2-type superfamily [IPR036443] 0.6347305737672788 1.2891908944465629 0.1973317298113781 1.0 0.263495898042252 8 P35637,Q01844,Q92804 3 +Lamin tail domain superfamily [IPR036415] 0.6162577810325889 1.219106792768636 0.2228036620463851 1.0 0.2949063048660608 3 Q03252,P02545 2 +Ribosomal protein S10 domain superfamily [IPR036838] 0.5344070278184542 1.1567646171905832 0.2473685415062263 1.0 0.3236464491176564 2 P60866 1 +R3H domain superfamily [IPR036867] 0.5983592706251406 1.1348527075017107 0.2564370378898064 1.0 0.3331113453561434 3 Q9H6S0 1 +Prefoldin [IPR009053] 0.6606815683400481 1.0978580940263971 0.2722664591997024 1.0 0.3511126913372772 5 O15212,P61758,Q9UHV9,Q9NQP4 4 +Ribosomal protein L37ae/L37e [IPR011331] 0.5230600292825756 1.0970603071056415 0.2726150301682604 1.0 0.3511126913372772 2 P61927 1 +Glycoside hydrolase superfamily [IPR017853] 0.4477953577327959 1.0505953418798648 0.2934444813700203 1.0 0.3736992834277397 16 Q9BTY2,O60502,Q9BWS9,P04062,P08236,P54802,P06865,P08195 8 +LDL receptor-like superfamily [IPR036055] 0.5131771595900537 1.0452124453649605 0.2959247927174777 1.0 0.3746044615014909 2 P01130 1 +Six-hairpin glycosidase-like superfamily [IPR012341] 0.5117130307467147 1.0375467554059394 0.2994811174767879 1.0 0.3761118321838498 2 Q13724 1 +B30.2/SPRY domain superfamily [IPR043136] 0.5254118557792 1.020683272608775 0.3074045221314063 1.0 0.3834111347463145 11 P14373,Q9BUJ2,Q1KMD3,Q12899 4 +Oxysterol-binding protein superfamily [IPR037239] 0.6416312435260497 1.0167422581624548 0.309276057200115 1.0 0.3852162687760005 5 Q9BZF3 1 +PDZ superfamily [IPR036034] 0.4274669383486283 0.989916557011276 0.3222149060288592 1.0 0.3959014001004116 17 O14936,Q14168,Q00013,Q9NZW5 4 +XPC-binding domain superfamily [IPR036353] 0.4952415812591604 0.9516647932093932 0.3412670099979817 1.0 0.4162410408155547 2 P54725 1 +Tetratricopeptide-like helical domain superfamily [IPR011990] 0.3106262499129945 0.9421740748015672 0.3461035247247712 1.0 0.4205676620945201 85 P13674,Q32P28,Q8IYR2,O75153,Q92791,Q96EK5,O75718,Q96BR5,O43242,O76024,Q9UBV2,Q96DB5,Q9Y5A7,Q13325,Q9UJX4,Q9BZJ0,P50542,Q9H0B6,Q6P2P2,A0AVF1,Q5R3I4 21 +Protein kinase-like domain superfamily [IPR011009] 0.3402789269154783 0.930674933984818 0.3520217396104192 1.0 0.4246269640775771 54 Q8NEB9,P35790,Q99640,P48729,P11802,P31751,P36507,O14936,Q13153,Q13555,Q13546 11 +Glutathione S-transferase, C-terminal domain superfamily [IPR036282] 0.4301153552572695 0.9304443137538916 0.3521410836458321 1.0 0.4246269640775771 16 O75431,Q13505 2 +GINS, helical bundle-like domain superfamily [IPR036224] 0.5291102160380812 0.8132239850028622 0.4160896502312301 1.0 0.4906615615713726 3 Q9BRT9,Q9Y248 2 +GroES-like superfamily [IPR011032] 0.4999355179315596 0.791722996778078 0.4285222102041011 1.0 0.5040131695146681 10 Q8N4Q0,Q8WWV3 2 +HIV integrase-binding domain superfamily [IPR036218] 0.4608345534407156 0.7754550097134539 0.4380708405120046 1.0 0.5112703382839334 2 Q7Z4V5 1 +HIT-like superfamily [IPR036265] 0.5199560600512634 0.7717531784624884 0.4402606277790948 1.0 0.5131664313522697 3 Q9BX68,Q69YN2 2 +LEM/LEM-like domain superfamily [IPR011015] 0.5570047894396545 0.7691659804296207 0.4417947831793176 1.0 0.5142944399061801 6 P42167,Q86XL3 2 +HotDog domain superfamily [IPR029069] 0.577654641827519 0.7487400117122543 0.4540139224984831 1.0 0.5251524097179907 5 Q9Y305,O14734 2 +Zinc finger, CCHC-type superfamily [IPR036875] 0.5049432442328818 0.7045993619527774 0.481059595691264 1.0 0.550822336554436 3 Q16629,Q9NUD5 2 +HECT, E3 ligase catalytic domain [IPR035983] 0.5377109093742541 0.6857577909684003 0.4928658572188544 1.0 0.5619272702522581 6 Q05086,Q96J02 2 +Ribosomal L18e/L15P superfamily [IPR036227] 0.5005492493592092 0.6851749675230532 0.4932335180518168 1.0 0.5619272702522581 3 P46776,Q9P015 2 +Arginyl tRNA synthetase N-terminal domain superfamily [IPR036695] 0.4418008784773016 0.6808188891854224 0.4959860962861477 1.0 0.5643551070524088 2 Q5T160 1 +SCP2 sterol-binding domain superfamily [IPR036527] 0.4965214207250094 0.6674708426136371 0.5044714280443552 1.0 0.5725750708303432 3 Q6YN16,P51659 2 +Ribonuclease III, endonuclease domain superfamily [IPR036389] 0.4366764275256205 0.6558046553554959 0.5119498207007811 1.0 0.5796140114667198 2 Q9UPY3 1 +CAP Gly-rich domain superfamily [IPR036859] 0.4209370424597333 0.5804562844883172 0.5616069585635644 1.0 0.6278572429487234 2 Q15813 1 +Ankyrin repeat-containing domain superfamily [IPR036770] 0.385496480726242 0.574652998628559 0.5655260008719591 1.0 0.629758761936879 15 Q86XL3 1 +DHS-like NAD/FAD-binding domain superfamily [IPR029035] 0.5322197262514006 0.5669262569279667 0.5707642841756444 1.0 0.6335623105519378 5 Q13423,A1L0T0 2 +DUSP-like superfamily [IPR035927] 0.466495789088246 0.53909331570259 0.5898224675774597 1.0 0.6515313875429847 3 Q9Y4E8,P51784 2 +HAD superfamily [IPR023214] 0.3662553711227611 0.5053900591521776 0.6132848995582942 1.0 0.6733527071329276 16 Q969T7,Q9HD20,Q9BSH5,Q9H857,Q9BXW7,P16615 6 +HAD-like superfamily [IPR036412] 0.3662553711227611 0.5053900591521776 0.6132848995582942 1.0 0.6733527071329276 16 Q969T7,Q9HD20,Q9BSH5,Q9H857,Q9BXW7,P16615 6 +EF-hand domain pair [IPR011992] 0.3008906442884122 0.4913127075860241 0.6232052934198795 1.0 0.6825939763875157 47 O95202,O43852,P80303,Q14257,Q9NWM8,Q9BRK5,Q02818,Q9Y680 8 +S-adenosyl-L-methionine-dependent methyltransferase [IPR029063] 0.3338425550596106 0.4322913769487185 0.6655296536064348 1.0 0.7200397363214609 23 Q8N6R0,P19623,P21964,Q6P2P2,Q7L592,Q86X55,Q08J23 7 +Bcl-2-like superfamily [IPR036834] 0.4179296298230108 0.3497275554407131 0.7265431717768385 1.0 0.7779495282704827 3 Q07820 1 +TGS-like [IPR012676] 0.4408580573622445 0.3042468703918723 0.7609398188343564 1.0 0.8082770941193475 6 Q9NYK5,Q9BW92,Q9Y295 3 +Six-hairpin glycosidase superfamily [IPR008928] 0.355783308931178 0.3023237181817381 0.762405299280762 1.0 0.8082770941193475 2 Q13724 1 +Coatomer, gamma subunit, appendage domain superfamily [IPR037067] 0.3495607613469923 0.2795229572535964 0.7798435225171203 1.0 0.8205074373644788 2 Q9Y678 1 +Acyl-CoA dehydrogenase-like, C-terminal [IPR036250] 0.4225528507445468 0.2733517312360619 0.7845828531240162 1.0 0.8235852377301811 7 O15254,Q15067 2 +Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain superfamily [IPR009100] 0.4225528507445468 0.2733517312360619 0.7845828531240162 1.0 0.8235852377301811 7 O15254,Q15067 2 +Acyl-CoA N-acyltransferase [IPR016181] 0.3859400441767759 0.2492398086768186 0.8031752879387417 1.0 0.840187974018868 10 O60502,O95251,O95260,P41227,O14929 5 +RmlC-like cupin domain superfamily [IPR011051] 0.429907482174873 0.230471301164133 0.8177255616291321 1.0 0.8514848738064816 4 O00625 1 +Beta-grasp domain superfamily [IPR012675] 0.3953379086317752 0.2103895699938089 0.8333636324280529 1.0 0.8647933465653395 8 P21912,Q9NYK5,Q9BW92,Q9Y295 4 +MFS transporter superfamily [IPR036259] 0.3885268694491223 0.1871598033291895 0.8515353401866237 1.0 0.8796292251302097 8 Q16625,P11166,Q7L0J3,P41440 4 +Concanavalin A-like lectin/glucanase domain superfamily [IPR013320] 0.2951773143971715 0.1296748725751535 0.8968236634609323 1.0 0.9222150469111288 19 Q1KMD3,P14373,O14967,Q12899,P50851,Q9BUJ2 6 +HSP40/DnaJ peptide-binding [IPR008971] 0.3808312102713607 0.1091366841564664 0.913094078905206 1.0 0.9356782439349128 4 O60884,Q96EY1 2 +Chaperone J-domain superfamily [IPR036869] 0.3035648658581481 0.0715641322660529 0.9429487851619917 1.0 0.9609399516577872 13 Q9NVH1,P31689,Q99543,Q13217,P25685,Q96EY1,Q9UGP8,Q96KC8,O75937,Q99615,O60884,Q8IXB1 12 +Threonyl/alanyl tRNA synthetase, class II-like, putative editing domain superfamily [IPR018163] 0.3512003535174677 0.0540627923347106 0.9568851362877506 1.0 0.9740489952346162 6 Q9NYK5,Q5JTZ9 2 +6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily [IPR008927] 0.3319758983546982 0.0280388426469716 0.9776311713628992 1.0 0.9929408317645552 8 P40939,Q16836 2 +RmlC-like jelly roll fold [IPR014710] 0.3251953693264141 0.0133407380436167 0.989355946815964 1.0 1.0 8 O00625 1 diff --git a/interpro_homologous_superfamily/selections.json b/interpro_homologous_superfamily/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..6f8738b487339fdfcb26f1894e6eb220012acdbf --- /dev/null +++ b/interpro_homologous_superfamily/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["14-3-3 domain superfamily [IPR036815]", "2Fe-2S ferredoxin-like superfamily [IPR036010]", "30s ribosomal protein S13, C-terminal [IPR027437]", "4'-phosphopantetheinyl transferase domain superfamily [IPR037143]", "5'-3' exonuclease, C-terminal domain superfamily [IPR036279]", "50S ribosomal protein L10, insertion domain superfamily [IPR043164]", "50S ribosomal protein L30e-like [IPR029064]", "6-phosphogluconate dehydrogenase, domain 2 [IPR013328]", "6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily [IPR008927]", "AAR2, C-terminal domain superfamily [IPR038514]", "AAR2, N-terminal domain superfamily [IPR038516]", "ABC transporter type 1, transmembrane domain superfamily [IPR036640]", "ACP-like superfamily [IPR036736]", "ADF-H/Gelsolin-like domain superfamily [IPR029006]", "ADP-ribosylation/Crystallin J1 superfamily [IPR036705]", "AF1104-like superfamily [IPR036075]", "AH/BAR domain superfamily [IPR027267]", "AICAR transformylase, duplicated domain superfamily [IPR024051]", "AICAR transformylase, insert domain superfamily [IPR024050]", "AMP-binding enzyme, C-terminal domain superfamily [IPR045851]", "ANL, N-terminal domain [IPR042099]", "ANTH domain superfamily [IPR014712]", "AP-2 complex subunit mu, C-terminal superfamily [IPR036168]", "APC, N-terminal coiled-coil domain superfamily [IPR036149]", "ARFGAP/RecO-like zinc finger [IPR037278]", "ARID DNA-binding domain superfamily [IPR036431]", "ATP synthase subunit alpha, N-terminal domain-like superfamily [IPR023366]", "ATP synthase, F0 complex, subunit D superfamily, mitochondrial [IPR036228]", "ATP synthase, F1 complex, gamma subunit superfamily [IPR035968]", "ATP synthase, alpha subunit, C-terminal domain superfamily [IPR038376]", "ATP-NAD kinase, PpnK-type, C-terminal [IPR017437]", "ATP-grasp fold, subdomain 1 [IPR013815]", "ATP:guanido phosphotransferase, N-terminal domain superfamily [IPR036802]", "ATPase, F1/V1 complex, beta/alpha subunit, C-terminal [IPR024034]", "ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain superfamily [IPR036121]", "ATPase, V1 complex, subunit H, C-terminal domain superfamily [IPR038497]", "ATPase, nucleotide binding domain [IPR043129]", "Acetylglutamate kinase-like superfamily [IPR036393]", "Aconitase, domain 2 [IPR015932]", "Aconitase, iron-sulfur domain [IPR036008]", "Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 1/3 [IPR015931]", "Aconitase/3-isopropylmalate dehydratase, swivel [IPR015928]", "Actin-crosslinking [IPR008999]", "Actin-related protein 2/3 complex subunit 3 superfamily [IPR036753]", "Actin-related protein 2/3 complex subunit 5 superfamily [IPR036743]", "Activator of Hsp90 ATPase, Aha1 [IPR036338]", "Acyl transferase domain superfamily [IPR001227]", "Acyl transferase/acyl hydrolase/lysophospholipase [IPR016035]", "Acyl-CoA N-acyltransferase [IPR016181]", "Acyl-CoA binding protein superfamily [IPR035984]", "Acyl-CoA dehydrogenase-like, C-terminal [IPR036250]", "Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain superfamily [IPR009100]", "Acyl-CoA dehydrogenase/oxidase, N-terminal domain superfamily [IPR037069]", "Acyl-CoA thioesterase, double hotdog domain [IPR042171]", "Adenomatous polyposis coli protein [IPR026831]", "Adenosylhomocysteinase-like superfamily [IPR042172]", "Adenylate cyclase-associated CAP, C-terminal superfamily [IPR036223]", "Adenylate cyclase-associated CAP, N-terminal domain superfamily [IPR036222]", "Adenylate kinase, active site lid domain superfamily [IPR036193]", "Adenylosuccinate synthetase, domain 1 [IPR042109]", "Adenylosuccinate synthetase, domain 2 [IPR042110]", "Adenylosuccinate synthetase, domain 3 [IPR042111]", "Alanine-tRNA ligase, class IIc, anti-codon-binding domain superfamily [IPR018162]", "Aldehyde dehydrogenase, C-terminal [IPR016163]", "Aldehyde dehydrogenase, N-terminal [IPR016162]", "Aldehyde/histidinol dehydrogenase [IPR016161]", "Aldolase-type TIM barrel [IPR013785]", "Alkaline-phosphatase-like, core domain superfamily [IPR017850]", "Allosteric substrate binding domain superfamily [IPR029009]", "Alpha-D-phosphohexomutase, C-terminal domain superfamily [IPR036900]", "Alpha-D-phosphohexomutase, alpha/beta/alpha I/II/III [IPR016055]", "Alpha-catenin/vinculin-like superfamily [IPR036723]", "Alpha-glycerophosphate oxidase, C-terminal domain superfamily [IPR038299]", "Alpha-helical ferredoxin [IPR009051]", "Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain superfamily [IPR036784]", "Alpha-ketoglutarate-dependent dioxygenase AlkB-like superfamily [IPR037151]", "Alpha/Beta hydrolase fold [IPR029058]", "Alpha/beta knot methyltransferases [IPR029028]", "Amidase signature (AS) superfamily [IPR036928]", "Aminoacyl-tRNA synthetase, class I, anticodon-binding domain, subdomain 2 [IPR020751]", "Aminoacyl-tRNA synthetase, class I, anticodon-binding superfamily [IPR008925]", "Aminoacyl-tRNA synthetase, class Ia, anticodon-binding [IPR009080]", "Aminopeptidase N-like , N-terminal domain superfamliy [IPR042097]", "Amyloidogenic glycoprotein, amyloid-beta peptide superfamily [IPR037071]", "Amyloidogenic glycoprotein, copper-binding domain superfamily [IPR036669]", "Amyloidogenic glycoprotein, heparin-binding domain superfamily [IPR036454]", "Ankyrin repeat-containing domain superfamily [IPR036770]", "Annexin superfamily [IPR037104]", "Anticodon-binding domain superfamily [IPR036621]", "Antifreeze-like/N-acetylneuraminic acid synthase C-terminal domain superfamily [IPR036732]", "ApaG domain superfamily [IPR036767]", "ArfGAP domain superfamily [IPR038508]", "Arginyl tRNA synthetase N-terminal domain superfamily [IPR036695]", "Armadillo-like helical [IPR011989]", "Armadillo-type fold [IPR016024]", "Arp2/3 complex subunit 2/4 [IPR034666]", "Arrestin-like, C-terminal [IPR014752]", "Aspartate decarboxylase-like domain superfamily [IPR009010]", "Aspartate/ornithine carbamoyltransferase superfamily [IPR036901]", "Aspartic peptidase domain superfamily [IPR021109]", "Aspartyl/glutamyl-tRNA amidotransferase subunit B-like [IPR003789]", "Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, C-terminal, domain 2 [IPR023168]", "At2g17340, three-helix bundle domain [IPR035073]", "B30.2/SPRY domain superfamily [IPR043136]", "BAG domain superfamily [IPR036533]", "BEACH domain superfamily [IPR036372]", "BRCT domain superfamily [IPR036420]", "BRK domain superfamily [IPR037259]", "BRO1 domain superfamily [IPR038499]", "BSD domain superfamily [IPR035925]", "Bacterial exopeptidase dimerisation domain [IPR036264]", "Band 7/SPFH domain superfamily [IPR036013]", "Barrier-to-autointegration factor, BAF superfamily [IPR036617]", "Bcl-2-like superfamily [IPR036834]", "Beta-Galactosidase/glucuronidase domain superfamily [IPR036156]", "Beta-catenin-interacting ICAT superfamily [IPR036911]", "Beta-grasp domain superfamily [IPR012675]", "Beta-hexosaminidase-like, domain 2 [IPR029018]", "Beta-lactamase/transpeptidase-like [IPR012338]", "Bromo adjacent homology (BAH) domain superfamily [IPR043151]", "Bromodomain-like superfamily [IPR036427]", "C-type lectin fold [IPR016187]", "C-type lectin-like/link domain superfamily [IPR016186]", "C2 domain superfamily [IPR035892]", "CAP Gly-rich domain superfamily [IPR036859]", "CCR4-NOT subunit 1, TTP binding domain superfamily [IPR038535]", "CDC48 domain 2-like superfamily [IPR029067]", "CDP-alcohol phosphatidyltransferase, transmembrane domain [IPR043130]", "CH domain superfamily [IPR036872]", "CRAL-TRIO lipid binding domain superfamily [IPR036865]", "CRAL/TRIO, N-terminal domain superfamily [IPR036273]", "CRIB domain superfamily [IPR036936]", "CSTF1, dimerization domain superfamily [IPR038184]", "Cadherin-like superfamily [IPR015919]", "Calcyclin-binding protein, N-terminal [IPR037201]", "Calpain large subunit, domain III superfamily [IPR036213]", "Calreticulin/calnexin, P domain superfamily [IPR009033]", "Calycin [IPR012674]", "Carbamoyl-phosphate synthase small subunit, N-terminal domain superfamily [IPR036480]", "Carbamoyl-phosphate synthetase, large subunit oligomerisation domain superfamily [IPR036897]", "Carboxypeptidase-like, regulatory domain superfamily [IPR008969]", "Carnitine o-acyltransferase, N-terminal [IPR042572]", "Casein kinase II subunit beta-like [IPR035991]", "Casein kinase II, regulatory subunit, N-terminal [IPR016149]", "Caspase-like domain superfamily [IPR029030]", "Catenin binding domain superfamily [IPR027397]", "Cathepsin C, exclusion domain superfamily [IPR036496]", "Cdc37, Hsp90-binding domain superfamily [IPR038189]", "Cell division control protein 73, C-terminal domain superfamily [IPR038103]", "Chaperone J-domain superfamily [IPR036869]", "Chitinase insertion domain superfamily [IPR029070]", "Chloramphenicol acetyltransferase-like domain superfamily [IPR023213]", "Chloride channel, core [IPR014743]", "Choline/Carnitine o-acyltransferase, domain 2 [IPR042231]", "Chromo-like domain superfamily [IPR016197]", "Citrate synthase superfamily [IPR036969]", "Citrate synthase-like, large alpha subdomain [IPR016142]", "Citrate synthase-like, small alpha subdomain [IPR016143]", "Class I and II aminoacyl-tRNA synthetase, tRNA-binding arm [IPR010978]", "Class I glutamine amidotransferase-like [IPR029062]", "Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL) [IPR045864]", "Class II aldolase/adducin N-terminal domain superfamily [IPR036409]", "Clathrin adaptor, appendage, Ig-like subdomain superfamily [IPR013041]", "Clathrin adaptor, beta-adaptin, appendage, Ig-like subdomain [IPR013037]", "Clathrin heavy chain, N-terminal [IPR016025]", "ClpP/crotonase-like domain superfamily [IPR029045]", "Coatomer, gamma subunit, appendage domain superfamily [IPR037067]", "Coatomer/calthrin adaptor appendage, C-terminal subdomain [IPR009028]", "Cobalamin (vitamin B12)-dependent enzyme, catalytic [IPR016176]", "Cobalamin adenosyltransferase-like superfamily [IPR036451]", "Cobalamin-binding domain superfamily [IPR036724]", "Concanavalin A-like lectin/glucanase domain superfamily [IPR013320]", "Creatinase/Aminopeptidase P/Spt16, N-terminal [IPR029149]", "Creatinase/aminopeptidase-like [IPR036005]", "Cullin homology domain superfamily [IPR036317]", "Cullin repeat-like-containing domain superfamily [IPR016159]", "Cupredoxin [IPR008972]", "Cyclase-associated protein CAP/septum formation inhibitor MinC, C-terminal [IPR016098]", "Cyclic nucleotide-binding-like [IPR018490]", "Cyclic phosphodiesterase [IPR009097]", "Cyclin-like superfamily [IPR036915]", "Cyclophilin-like domain superfamily [IPR029000]", "Cytidine deaminase-like [IPR016193]", "Cytochrome C oxidase subunit II, transmembrane domain superfamily [IPR036257]", "Cytochrome P450 superfamily [IPR036396]", "Cytochrome b-c1 complex subunit 7 superfamily [IPR036544]", "Cytochrome b-c1 complex subunit 8 superfamily [IPR036642]", "Cytochrome b-c1 complex subunit 9 superfamily [IPR036656]", "Cytochrome b5-like heme/steroid binding domain superfamily [IPR036400]", "Cytochrome c oxidase subunit IV superfamily [IPR036639]", "Cytochrome c oxidase subunit VIIc superfamily [IPR036636]", "Cytochrome c oxidase, subunit VIIa superfamily [IPR036539]", "Cytochrome c oxidase, subunit Va/VI superfamily [IPR036545]", "Cytochrome c oxidase, subunit Vb superfamily [IPR036972]", "Cytochrome c-like domain superfamily [IPR036909]", "Cytochrome c1, transmembrane anchor, C-terminal [IPR021157]", "Cytochrome cd1-nitrite reductase-like, haem d1 domain superfamily [IPR011048]", "DCN1-like, PONY binding domain [IPR042460]", "DHBP synthase RibB-like alpha/beta domain superfamily [IPR017945]", "DHS-like NAD/FAD-binding domain superfamily [IPR029035]", "DNA breaking-rejoining enzyme, catalytic core [IPR011010]", "DNA fragmentation factor 45kDa, C-terminal [IPR027296]", "DNA ligase, ATP-dependent, N-terminal domain superfamily [IPR036599]", "DNA mismatch repair protein MutS, N-terminal [IPR016151]", "DNA mismatch repair protein MutS, core domain superfamily [IPR036187]", "DNA polymerase III, clamp loader complex, gamma/delta/delta subunit, C-terminal [IPR008921]", "DNA polymerase alpha, subunit B, N-terminal domain superfamily [IPR043034]", "DNA polymerase alpha, zinc finger domain superfamily [IPR038256]", "DNA polymerase family B, thumb domain [IPR042087]", "DNA polymerase, palm domain superfamily [IPR023211]", "DNA repair protein XRCC4-like, C-terminal [IPR014751]", "DNA topoisomerase I, DNA binding, N-terminal domain 1 [IPR013034]", "DNA topoisomerase I, DNA binding, N-terminal domain 2 [IPR013030]", "DNA topoisomerase I, DNA binding, eukaryotic-type, N-terminal domain superfamily [IPR036202]", "DNA topoisomerase I, catalytic core, alpha-helical subdomain, eukaryotic-type [IPR014711]", "DNA topoisomerase I, catalytic core, alpha/beta subdomain [IPR014727]", "DNA topoisomerase, type IIA, alpha-helical domain superfamily [IPR013757]", "DNA topoisomerase, type IIA, domain A, alpha-beta [IPR013758]", "DNA topoisomerase, type IIA, subunit B, C-terminal [IPR013759]", "DNA topoisomerase, type IIA-like domain superfamily [IPR013760]", "DNA-binding domain superfamily [IPR016177]", "DNA-directed RNA polymerase, N-terminal domain superfamily [IPR037159]", "DNA-directed RNA polymerase, insert domain superfamily [IPR036643]", "DNA-directed RNA polymerase, subunit 2, hybrid-binding domain superfamily [IPR037033]", "DNA/RNA non-specific endonuclease superfamily [IPR044929]", "DNA/RNA polymerase superfamily [IPR043502]", "DUSP-like superfamily [IPR035927]", "Dbl homology (DH) domain superfamily [IPR035899]", "Death-like domain superfamily [IPR011029]", "Dedicator of cytokinesis, C-terminal, lobe A [IPR043161]", "Dedicator of cytokinesis, C-terminal, lobe C [IPR043162]", "Deoxyhypusine synthase superfamily [IPR036982]", "DhaL domain superfamily [IPR036117]", "Diaphanous, GTPase-binding domain superfamily [IPR044933]", "Dicer dimerisation domain superfamily [IPR038248]", "Dihydrofolate reductase-like domain superfamily [IPR024072]", "Dihydropteroate synthase-like [IPR011005]", "Dimeric alpha-beta barrel [IPR011008]", "Diphthamide synthesis DPH1/DPH2, domain 1 [IPR042263]", "Diphthamide synthesis DPH1/DPH2, domain 3 [IPR042265]", "Dynein heavy chain AAA lid domain superfamily [IPR042219]", "Dynein heavy chain, AAA1 domain, small subdomain [IPR043157]", "Dynein heavy chain, C-terminal domain, barrel region [IPR043160]", "Dynein heavy chain, domain 2, N-terminal [IPR042222]", "Dynein heavy chain, linker, subdomain 3 [IPR042228]", "Dynein light chain superfamily [IPR037177]", "E2 domain superfamily [IPR036176]", "E3-binding domain superfamily [IPR036625]", "EB1, C-terminal domain superfamily [IPR036133]", "EF-G domain III/V-like [IPR035647]", "EF-hand domain pair [IPR011992]", "ENTH/VHS [IPR008942]", "ERO1-like superfamily [IPR037192]", "ESCRT assembly domain [IPR037202]", "EXOC6/PINT-1/Sec15/Tip20, C-terminal, domain 2 [IPR042044]", "Elongation factor EF1B gamma, C-terminal domain superfamily [IPR036433]", "Elongation factor Ts, dimerisation domain superfamily [IPR036402]", "Endonuclease/exonuclease/phosphatase superfamily [IPR036691]", "Endoplasmic reticulum resident protein 29, C-terminal domain superfamily [IPR036356]", "Enhancer of mRNA-decapping protein 4, conserved C-terminal domain [IPR044938]", "Enhancer of rudimentary superfamily [IPR035912]", "Enolase-like, C-terminal domain superfamily [IPR036849]", "Enolase-like, N-terminal [IPR029017]", "Enoyl-CoA hydratase, C-terminal [IPR014748]", "Eukaryotic translation initiation factor 3-like domain superfamily [IPR023194]", "Exoribonuclease, PH domain 2 superfamily [IPR036345]", "F-actin capping protein, alpha subunit, domain 1 [IPR042489]", "F-actin-capping protein subunit alpha/beta [IPR037282]", "F-actin-capping protein subunit alpha/beta, domain 2 [IPR042276]", "F-actin-capping protein subunit beta, N-terminal domain [IPR043175]", "F-box-like domain superfamily [IPR036047]", "F1F0 ATP synthase OSCP/delta subunit, N-terminal domain superfamily [IPR026015]", "FAD-binding, type PCMH, subdomain 1 [IPR016167]", "FAD-binding, type PCMH, subdomain 2 [IPR016169]", "FAD-binding, type PCMH-like superfamily [IPR036318]", "FAD-linked oxidase-like, C-terminal [IPR016164]", "FAD/NAD(P)-binding domain superfamily [IPR036188]", "FAD/NAD-linked reductase, dimerisation domain superfamily [IPR016156]", "FERM superfamily, second domain [IPR035963]", "FERM/acyl-CoA-binding protein superfamily [IPR014352]", "FF domain superfamily [IPR036517]", "FKBP12-rapamycin binding domain superfamily [IPR036738]", "FTO, C-terminal domain superfamily [IPR038413]", "Ferredoxin-NADP reductase (FNR), nucleotide-binding domain [IPR039261]", "Ferritin-like superfamily [IPR009078]", "Fibronectin type II domain superfamily [IPR036943]", "Fibronectin type III superfamily [IPR036116]", "Flavoprotein-like superfamily [IPR029039]", "Formin, FH2 domain superfamily [IPR042201]", "Formyl transferase, N-terminal domain superfamily [IPR036477]", "Fumarase/histidase, N-terminal [IPR024083]", "Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain superfamily [IPR037099]", "Fumarylacetoacetase, N-terminal domain superfamily [IPR036462]", "Fumarylacetoacetase-like, C-terminal domain superfamily [IPR036663]", "G protein alpha subunit, helical insertion [IPR011025]", "GAD-like domain superfamily [IPR004115]", "GAR domain superfamily [IPR036534]", "GAT domain superfamily [IPR038425]", "GHMP kinase, C-terminal domain superfamily [IPR036554]", "GINS complex, subunit Psf3 superfamily [IPR038437]", "GINS, helical bundle-like domain superfamily [IPR036224]", "GM2-AP, lipid-recognition domain superfamily [IPR036846]", "GMP phosphodiesterase, delta subunit superfamily [IPR037036]", "GOLD domain superfamily [IPR036598]", "GSKIP domain superfamily [IPR023231]", "GTF2I-like repeat superfamily [IPR036647]", "GTP-binding protein TrmE/Aminomethyltransferase GcvT, domain 1 [IPR027266]", "GTP-binding protein, orthogonal bundle domain superfamily [IPR023179]", "GTP1/OBG domain superfamily [IPR036726]", "GYF-like domain superfamily [IPR035445]", "Galactose mutarotase-like domain superfamily [IPR011013]", "Galactose oxidase/kelch, beta-propeller [IPR011043]", "Galactose-binding-like domain superfamily [IPR008979]", "Gamma-glutamyl cyclotransferase-like superfamily [IPR036568]", "Gamma-tubulin complex component, C-terminal domain superfamily [IPR042241]", "Gelsolin-like domain superfamily [IPR036180]", "Glu-tRNAGln amidotransferase superfamily, subunit C [IPR036113]", "Glutamine synthetase/guanido kinase, catalytic domain [IPR014746]", "Glutaminyl-tRNA synthetase, class Ib, non-specific RNA-binding domain, N-terminal, subdomain 1 [IPR042558]", "Glutaminyl-tRNA synthetase, class Ib, non-specific RNA-binding domain, N-terminal, subdomain 2 [IPR042559]", "Glutathione S-transferase, C-terminal domain superfamily [IPR036282]", "Glutathione synthase, C-terminal, eukaryotic [IPR014709]", "Glutathione synthase, N-terminal, eukaryotic [IPR014049]", "Glutathione synthase, alpha-helical [IPR014042]", "Glutathione synthase, substrate-binding domain superfamily [IPR037013]", "Glycoside hydrolase superfamily [IPR017853]", "Glycosyl hydrolase family 63, N-terminal domain superfamily [IPR038518]", "Glycosyl hydrolase, all-beta [IPR013780]", "Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase [IPR029068]", "Golgi phosphoprotein 3-like domain superfamily [IPR038261]", "GroEL-like apical domain superfamily [IPR027409]", "GroEL-like equatorial domain superfamily [IPR027413]", "GroES chaperonin superfamily [IPR037124]", "GroES-like superfamily [IPR011032]", "Growth arrest and DNA damage-inducible proteins-interacting protein 1 domain superfamily [IPR043035]", "Growth factor receptor cysteine-rich domain superfamily [IPR009030]", "GrpE nucleotide exchange factor, coiled-coil [IPR013805]", "GrpE nucleotide exchange factor, head [IPR009012]", "Guanylate-binding protein, C-terminal domain superfamily [IPR036543]", "H/ACA RNP complex subunit Gar1/Naf1, Cbf5-binding domain [IPR038664]", "H/ACA ribonucleoprotein complex, subunit Nop10 superfamily [IPR036756]", "HAD superfamily [IPR023214]", "HAD-like superfamily [IPR036412]", "HAD-superfamily hydrolase, subfamily IA, REG-2-like, capping domain superfamily [IPR044924]", "HBS1-like protein, N-terminal domain superfamily [IPR037189]", "HECT, E3 ligase catalytic domain [IPR035983]", "HIT-like superfamily [IPR036265]", "HIV integrase-binding domain superfamily [IPR036218]", "HORMA domain superfamily [IPR036570]", "HR1 repeat superfamily [IPR036274]", "HRDC domain superfamily [IPR044876]", "HRDC-like superfamily [IPR010997]", "HSP20-like chaperone [IPR008978]", "HSP40/DnaJ peptide-binding [IPR008971]", "HSP90, C-terminal domain [IPR037196]", "Haem oxygenase-like, multi-helical [IPR016084]", "Heat shock protein 70kD, C-terminal domain superfamily [IPR029048]", "Heat shock protein 70kD, peptide-binding domain superfamily [IPR029047]", "Heat shock protein DnaJ, cysteine-rich domain superfamily [IPR036410]", "Heavy metal-associated domain superfamily [IPR036163]", "Hemimethylated DNA-binding domain superfamily [IPR036623]", "High mobility group box domain superfamily [IPR036910]", "His-Me finger superfamily [IPR044925]", "Histidine kinase/HSP90-like ATPase superfamily [IPR036890]", "Histidine phosphatase superfamily [IPR029033]", "Histone acetyl transferase 1, N-terminal domain superfamily [IPR037113]", "Histone acetyltransferase HAT1, C-terminal [IPR013523]", "Histone chaperone ASF1-like superfamily [IPR036747]", "Histone deacetylase domain superfamily [IPR037138]", "Histone-fold [IPR009072]", "Homeobox-like domain superfamily [IPR009057]", "Homocysteine-binding domain superfamily [IPR036589]", "HotDog domain superfamily [IPR029069]", "I/LWEQ domain superfamily [IPR035964]", "ISWI, HAND domain superfamily [IPR036306]", "Immunoglobulin E-set [IPR014756]", "Immunoglobulin-like domain superfamily [IPR036179]", "Immunoglobulin-like fold [IPR013783]", "Importin-alpha, importin-beta-binding domain superfamily [IPR036975]", "Initiation factor 2B-like, C-terminal [IPR042529]", "Inorganic polyphosphate/ATP-NAD kinase, N-terminal [IPR017438]", "Inorganic pyrophosphatase superfamily [IPR036649]", "Inosine triphosphate pyrophosphatase-like [IPR029001]", "Integrin beta tail domain superfamily [IPR036349]", "Integrin domain superfamily [IPR032695]", "Invasin/intimin cell-adhesion fragments [IPR008964]", "Isochorismatase-like superfamily [IPR036380]", "Isopenicillin N synthase-like superfamily [IPR027443]", "Isoprenoid synthase domain superfamily [IPR008949]", "K Homology domain, type 1 superfamily [IPR036612]", "K homology domain superfamily, prokaryotic type [IPR009019]", "K homology domain-like, alpha/beta [IPR015946]", "Kelch-type beta propeller [IPR015915]", "Kinesin motor domain superfamily [IPR036961]", "Kinesin-like protein Kif23, Arf6-interacting domain superfamily [IPR038105]", "Kringle-like fold [IPR013806]", "Ku, C-terminal domain superfamily [IPR036494]", "Ku70, bridge and pillars domain superfamily [IPR027388]", "L-Aspartase-like [IPR008948]", "L1 transposable element, C-terminal domain [IPR042566]", "L21-like superfamily [IPR036164]", "L27 domain superfamily [IPR036892]", "LAP1C-like, C-terminal domain superfamily [IPR038599]", "LDL receptor-like superfamily [IPR036055]", "LEM/LEM-like domain superfamily [IPR011015]", "LIS1, N-terminal [IPR037190]", "LSM domain superfamily [IPR010920]", "Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal [IPR015955]", "Lambda repressor-like, DNA-binding domain superfamily [IPR010982]", "Lamin tail domain superfamily [IPR036415]", "Leucine-rich repeat domain superfamily [IPR032675]", "LexA/Signal peptidase-like superfamily [IPR036286]", "Longin-like domain superfamily [IPR011012]", "MAGE homology domain, winged helix WH1 motif [IPR041898]", "MAGE homology domain, winged helix WH2 motif [IPR041899]", "MAN1, winged-helix domain [IPR041885]", "MFS transporter superfamily [IPR036259]", "MHC class I-like antigen recognition-like superfamily [IPR037055]", "MHC classes I/II-like antigen recognition protein [IPR011162]", "MIT domain superfamily [IPR036181]", "MRG, C-terminal domain superfamily [IPR038217]", "MRP-L47 superfamily, mitochondrial [IPR038340]", "Macro domain-like [IPR043472]", "Malic enzyme, N-terminal domain superfamily [IPR037062]", "Malonyl-CoA ACP transacylase, ACP-binding [IPR016036]", "Manganese/iron superoxide dismutase, C-terminal domain superfamily [IPR036314]", "Manganese/iron superoxide dismutase, N-terminal domain superfamily [IPR036324]", "Mannose-6-phosphate receptor binding domain superfamily [IPR009011]", "Membrane associated eicosanoid/glutathione metabolism-like domain superfamily [IPR023352]", "Metal-dependent hydrolase [IPR032466]", "Metal-dependent hydrolase, composite domain superfamily [IPR011059]", "Metallo-dependent phosphatase-like [IPR029052]", "Metalloenzyme, LuxS/M16 peptidase-like [IPR011249]", "Metallopeptidase, catalytic domain superfamily [IPR024079]", "Methionine synthase domain [IPR036594]", "Methionyl-tRNA synthetase, Zn-domain [IPR029038]", "Methylglyoxal synthase-like domain superfamily [IPR036914]", "Mib/herc2 domain superfamily [IPR037252]", "MitoNEET, CDGSH iron-sulfur domain [IPR042216]", "Mitochondrial carrier domain superfamily [IPR023395]", "Mitochondrial cytochrome c oxidase subunit VIc/VIIs superfamily [IPR037169]", "Mitochondrial glycoprotein superfamily [IPR036561]", "Mitochondrial outer membrane translocase complex, Tom20 domain superfamily [IPR023392]", "MoaB/Mog-like domain superfamily [IPR036425]", "MoeA, C-terminal, domain IV superfamily [IPR036688]", "MoeA, N-terminal and linker domain superfamily [IPR036135]", "Moesin tail domain superfamily [IPR008954]", "Mre11, capping domain [IPR038487]", "Mss4-like superfamily [IPR011057]", "Mss4/translationally controlled tumour-associated TCTP [IPR011323]", "Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal domain superfamily [IPR042179]", "MutS, connector domain superfamily [IPR036678]", "Myosin S1 fragment, N-terminal [IPR008989]", "NAC A/B domain superfamily [IPR038187]", "NAD kinase/diacylglycerol kinase-like domain superfamily [IPR016064]", "NAD(P)-binding domain superfamily [IPR036291]", "NADH-quinone oxidoreductase subunit E, N-terminal [IPR041921]", "NADH-ubiquinone oxidoreductase 51kDa subunit, FMN-binding domain superfamily [IPR037225]", "NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain superfamily [IPR037207]", "NADH:ubiquinone oxidoreductase, 30kDa subunit superfamily [IPR037232]", "NADP-dependent oxidoreductase domain superfamily [IPR036812]", "NADPH-cytochrome p450 reductase, FAD-binding, alpha-helical domain superfamily [IPR023173]", "NAP-like superfamily [IPR037231]", "NET domain superfamily [IPR038336]", "NO signalling/Golgi transport ligand-binding domain superfamily [IPR024096]", "NSFL1 cofactor p47, SEP domain superfamily [IPR036241]", "NTF2-like domain superfamily [IPR032710]", "NUDIX hydrolase-like domain superfamily [IPR015797]", "NVL2, N-terminal domain superfamily [IPR038100]", "NagB/RpiA transferase-like [IPR037171]", "Neurolysin/Thimet oligopeptidase, N-terminal [IPR024080]", "Neurolysin/Thimet oligopeptidase, domain 2 [IPR024077]", "Nibrin, second BRCT domain superfamily [IPR043014]", "Nicotinate phosphoribosyltransferase-like, C-terminal [IPR036068]", "Nitrogen regulatory PII-like, alpha/beta [IPR011322]", "Nitrogen regulatory protein PII/ATP phosphoribosyltransferase, C-terminal [IPR015867]", "Nitrous oxide reductase, N-terminal [IPR011045]", "Nop domain superfamily [IPR036070]", "Nop, C-terminal domain [IPR042239]", "Nucleic acid-binding, OB-fold [IPR012340]", "Nucleophile aminohydrolases, N-terminal [IPR029055]", "Nucleoplasmin core domain superfamily [IPR036824]", "Nucleoporin, Nup155-like, C-terminal, subdomain 1 [IPR042533]", "Nucleoporin, Nup155-like, C-terminal, subdomain 2 [IPR042537]", "Nucleoporin, Nup155-like, C-terminal, subdomain 3 [IPR042538]", "Nucleoside diphosphate kinase-like domain superfamily [IPR036850]", "Nucleoside phosphorylase superfamily [IPR035994]", "Nucleotide-binding alpha-beta plait domain superfamily [IPR012677]", "Nucleotide-diphospho-sugar transferases [IPR029044]", "Nucleotidyltransferase superfamily [IPR043519]", "NusG, N-terminal domain superfamily [IPR036735]", "Oxygen-dependent coproporphyrinogen III oxidase superfamily [IPR036406]", "Oxysterol-binding protein superfamily [IPR037239]", "P-loop containing nucleoside triphosphate hydrolase [IPR027417]", "P-type ATPase, A domain superfamily [IPR008250]", "P-type ATPase, cytoplasmic domain N [IPR023299]", "P-type ATPase, transmembrane domain superfamily [IPR023298]", "P-type trefoil domain superfamily [IPR044913]", "PABC (PABP) domain [IPR036053]", "PADR1 domain superfamily [IPR038650]", "PAS domain superfamily [IPR035965]", "PAZ domain superfamily [IPR036085]", "PBDC1-like domain superfamily [IPR023139]", "PD-(D/E)XK endonuclease-like domain superfamily [IPR011604]", "PDCD5-like superfamily [IPR036883]", "PDZ superfamily [IPR036034]", "PEBP-like superfamily [IPR036610]", "PFU domain superfamily [IPR038122]", "PH-like domain superfamily [IPR011993]", "PIN-like domain superfamily [IPR029060]", "PITH domain superfamily [IPR037047]", "PKD domain superfamily [IPR035986]", "PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily [IPR017946]", "PNPase/RNase PH domain superfamily [IPR027408]", "POLO box domain superfamily [IPR036947]", "PPM-type phosphatase domain superfamily [IPR036457]", "PRP4-like superfamily [IPR036285]", "PTPA superfamily [IPR037218]", "PUA domain superfamily [IPR036974]", "PUA-like superfamily [IPR015947]", "PWI domain superfamily [IPR036483]", "PX domain superfamily [IPR036871]", "Pancreatic trypsin inhibitor Kunitz domain superfamily [IPR036880]", "PapD-like superfamily [IPR008962]", "Papain-like cysteine peptidase superfamily [IPR038765]", "Pectin lyase fold [IPR012334]", "Pectin lyase fold/virulence factor [IPR011050]", "Pelota/DOM34, N-terminal domain [IPR038069]", "Peptidase C12, ubiquitin carboxyl-terminal hydrolase superfamily [IPR036959]", "Peptidase C65, otubain, subdomain 2 [IPR042467]", "Peptidase C65, otubain, subdomain 1 [IPR042468]", "Peptidase M1, LTA-4 hydrolase/aminopeptidase, C-terminal domain superfamily [IPR038502]", "Peptidase M13, domain 2 [IPR042089]", "Peptidase M4/M1, CTD superfamily [IPR027268]", "Peptidase M41-like [IPR037219]", "Peptidase M60, enhancin-like domain 3 [IPR042279]", "Peptidase S1, PA clan [IPR009003]", "Peptidase S59, nucleoporin superfamily [IPR036903]", "Peptidase S8/S53 domain superfamily [IPR036852]", "Peptidyl-tRNA hydrolase II domain superfamily [IPR023476]", "Pex19, C-terminal domain superfamily [IPR038322]", "Phenylalanyl-tRNA synthetase-like, B3/B4 [IPR020825]", "Phosphatidic acid phosphatase type 2/haloperoxidase superfamily [IPR036938]", "Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily [IPR036940]", "Phosphatidylinositol-4-phosphate 5-kinase, N-terminal [IPR027484]", "Phosphoenolpyruvate carboxykinase, C-terminal [IPR013035]", "Phosphoenolpyruvate carboxykinase, N-terminal [IPR008210]", "Phosphofructokinase superfamily [IPR035966]", "Phosphoglucose isomerase, C-terminal [IPR023096]", "Phosphoglycerate kinase superfamily [IPR036043]", "Phosphoglycerate kinase, N-terminal [IPR015824]", "Phosphoglycolate phosphatase-like, domain 2 [IPR023198]", "Phosphoinositide 3-kinase, accessory (PIK) domain superfamily [IPR042236]", "Phospholipase B-like, domain 1 [IPR043040]", "Phospholipase B-like, domain 2 [IPR043041]", "Phospholipase B-like, domain 3 [IPR043042]", "Phosphoribosylformylglycinamidine synthase subunit PurS-like superfamily [IPR036604]", "Phosphoribosylglycinamide synthetase, C-domain superfamily [IPR037123]", "Phosphoribosyltransferase-like [IPR029057]", "Phosphotyrosine protein phosphatase I superfamily [IPR036196]", "Phosphotyrosyl phosphatase activator, C-terminal lid domain [IPR043170]", "Plakin repeat superfamily [IPR035915]", "Poly(ADP-ribose) polymerase, regulatory domain superfamily [IPR036616]", "Polyketide synthase, dehydratase domain superfamily [IPR042104]", "Polymerase/histidinol phosphatase-like [IPR016195]", "Polyribonucleotide nucleotidyltransferase, RNA-binding domain superfamily [IPR036456]", "Porin domain superfamily [IPR023614]", "Porphobilinogen deaminase, C-terminal domain superfamily [IPR036803]", "Pre-ATP-grasp domain superfamily [IPR016185]", "Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding domain superfamily [IPR042516]", "Prefoldin [IPR009053]", "Profilin superfamily [IPR036140]", "Prolyl-tRNA synthetase, class II [IPR017449]", "Proteasome activator PA28, C-terminal domain superfamily [IPR036997]", "Proteasome activator PA28, N-terminal domain superfamily [IPR036996]", "Proteasome activator superfamily [IPR036252]", "Protein arginine methyltransferase NDUFAF7 superfamily [IPR038375]", "Protein kinase-like domain superfamily [IPR011009]", "Protein-tyrosine phosphatase-like [IPR029021]", "Prp8 RNase domain IV, fingers region [IPR043173]", "Prp8 RNase domain IV, palm region [IPR043172]", "Pseudouridine synthase, TruD, catalytic domain [IPR042214]", "Pseudouridine synthase, catalytic domain superfamily [IPR020103]", "Pterin 4 alpha carbinolamine dehydratase superfamily [IPR036428]", "PurM-like, C-terminal domain superfamily [IPR036676]", "PurM-like, N-terminal domain superfamily [IPR036921]", "Putative DNA-binding domain superfamily [IPR009061]", "Pyridoxal phosphate-dependent transferase [IPR015424]", "Pyridoxal phosphate-dependent transferase, major domain [IPR015421]", "Pyridoxal phosphate-dependent transferase, small domain [IPR015422]", "Pyruvate kinase, C-terminal domain superfamily [IPR036918]", "Pyruvate kinase, insert domain superfamily [IPR015806]", "Pyruvate kinase-like domain superfamily [IPR040442]", "Pyruvate kinase-like, insert domain superfamily [IPR011037]", "Pyruvate/Phosphoenolpyruvate kinase-like domain superfamily [IPR015813]", "Quinoprotein alcohol dehydrogenase-like superfamily [IPR011047]", "Quinoprotein amine dehydrogenase, beta chain-like [IPR011044]", "R3H domain superfamily [IPR036867]", "RAP domain superfamily [IPR036744]", "RGS domain superfamily [IPR036305]", "RGS, subdomain 2 [IPR044926]", "RNA 3'-terminal phosphate cyclase domain superfamily [IPR037136]", "RNA 3'-terminal phosphate cyclase, insert domain superfamily [IPR036553]", "RNA 3'-terminal phosphate cyclase/enolpyruvate transferase, alpha/beta [IPR013792]", "RNA polymerase Rpb1, clamp domain superfamily [IPR044893]", "RNA polymerase Rpb1, domain 3 superfamily [IPR042102]", "RNA polymerase Rpb1, domain 7 superfamily [IPR038593]", "RNA polymerase Rpb1, funnel domain superfamily [IPR038120]", "RNA polymerase Rpb2, OB-fold [IPR014724]", "RNA polymerase Rpb2, domain 2 superfamily [IPR037034]", "RNA polymerase Rpb5, N-terminal domain superfamily [IPR036710]", "RNA polymerase Rpb7-like, N-terminal domain superfamily [IPR036898]", "RNA polymerase subunit RPB10 [IPR023580]", "RNA polymerase, RBP11-like subunit [IPR036603]", "RNA-binding S4 domain superfamily [IPR036986]", "RNA-binding domain superfamily [IPR035979]", "RPB5-like RNA polymerase subunit superfamily [IPR035913]", "RUN domain superfamily [IPR037213]", "Rab-GTPase-TBC domain superfamily [IPR035969]", "Ran-GTPase activating protein 1, C-terminal domain superfamily [IPR036720]", "Ras guanine nucleotide exchange factor domain superfamily [IPR023578]", "Ras guanine-nucleotide exchange factor, catalytic domain superfamily [IPR036964]", "Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II [IPR009091]", "Regulatory factor, effector binding domain superfamily [IPR011256]", "Rel homology domain (RHD), DNA-binding domain superfamily [IPR037059]", "Restriction endonuclease type II-like [IPR011335]", "Rho GDP-dissociation inhibitor domain superfamily [IPR024792]", "Rho GTPase activation protein [IPR008936]", "Rhodanese-like domain superfamily [IPR036873]", "Rhomboid-like superfamily [IPR035952]", "Riboflavin synthase-like beta-barrel [IPR017938]", "Ribokinase-like [IPR029056]", "Ribonuclease H superfamily [IPR036397]", "Ribonuclease H-like superfamily [IPR012337]", "Ribonuclease H1, N-terminal domain superfamily [IPR037056]", "Ribonuclease HII, helix-loop-helix cap domain superfamily [IPR023160]", "Ribonuclease III, endonuclease domain superfamily [IPR036389]", "Ribonuclease T2-like superfamily [IPR036430]", "Ribonuclease Z/Hydroxyacylglutathione hydrolase-like [IPR036866]", "Ribonucleotide reductase R1 subunit, N-terminal [IPR008926]", "Ribonucleotide reductase-like [IPR012348]", "Ribosomal L15/L27a, N-terminal [IPR027386]", "Ribosomal L18e/L15P superfamily [IPR036227]", "Ribosomal RNA-processing protein 8, N-terminal domain [IPR042036]", "Ribosomal protein L1, 3-layer alpha/beta-sandwich [IPR016095]", "Ribosomal protein L1-like [IPR023674]", "Ribosomal protein L10-like domain superfamily [IPR043141]", "Ribosomal protein L10e/L16 superfamily [IPR036920]", "Ribosomal protein L11, C-terminal domain superfamily [IPR036769]", "Ribosomal protein L11/L12, N-terminal domain superfamily [IPR036796]", "Ribosomal protein L13 superfamily [IPR036899]", "Ribosomal protein L14 superfamily [IPR036853]", "Ribosomal protein L15e core domain superfamily [IPR024794]", "Ribosomal protein L17 superfamily [IPR036373]", "Ribosomal protein L19 superfamily [IPR038657]", "Ribosomal protein L19/L19e superfamily [IPR035970]", "Ribosomal protein L19/L19e, domain 1 [IPR015972]", "Ribosomal protein L2, domain 2 [IPR014722]", "Ribosomal protein L2, domain 3 [IPR014726]", "Ribosomal protein L20, C-terminal [IPR035566]", "Ribosomal protein L21 superfamily [IPR036948]", "Ribosomal protein L22/L17 superfamily [IPR036394]", "Ribosomal protein L22e superfamily [IPR038526]", "Ribosomal protein L23/L15e core domain superfamily [IPR012678]", "Ribosomal protein L24e/L24 superfamily [IPR038630]", "Ribosomal protein L25/Gln-tRNA synthetase, N-terminal [IPR020056]", "Ribosomal protein L25/Gln-tRNA synthetase, anti-codon-binding domain superfamily [IPR011035]", "Ribosomal protein L27e superfamily [IPR038655]", "Ribosomal protein L29/L35 superfamily [IPR036049]", "Ribosomal protein L3, domain 3, archaeal type superfamily [IPR044892]", "Ribosomal protein L30, ferredoxin-like fold domain superfamily [IPR036919]", "Ribosomal protein L31e domain superfamily [IPR023621]", "Ribosomal protein L32e superfamily [IPR036351]", "Ribosomal protein L35A superfamily [IPR038661]", "Ribosomal protein L36e domain superfamily [IPR038097]", "Ribosomal protein L37ae/L37e [IPR011331]", "Ribosomal protein L38e superfamily [IPR038464]", "Ribosomal protein L4 domain superfamily [IPR023574]", "Ribosomal protein L5 domain superfamily [IPR022803]", "Ribosomal protein L6, alpha-beta domain superfamily [IPR036789]", "Ribosomal protein L7/L12, C-terminal/adaptor protein ClpS-like [IPR014719]", "Ribosomal protein L7/L12, oligomerisation domain superfamily [IPR036235]", "Ribosomal protein L9, N-terminal domain superfamily [IPR036935]", "Ribosomal protein L9/RNase H1, N-terminal [IPR009027]", "Ribosomal protein P1/P2, N-terminal domain [IPR038716]", "Ribosomal protein S10 domain superfamily [IPR036838]", "Ribosomal protein S11 superfamily [IPR036967]", "Ribosomal protein S13-like, H2TH [IPR010979]", "Ribosomal protein S17e-like superfamily [IPR036401]", "Ribosomal protein S19/S15, superfamily [IPR023575]", "Ribosomal protein S2, flavodoxin-like domain superfamily [IPR023591]", "Ribosomal protein S21e superfamily [IPR038579]", "Ribosomal protein S3, C-terminal domain superfamily [IPR036419]", "Ribosomal protein S4e, central domain superfamily [IPR038237]", "Ribosomal protein S5 domain 2-type fold [IPR020568]", "Ribosomal protein S5 domain 2-type fold, subgroup [IPR014721]", "Ribosomal protein S7 domain superfamily [IPR036823]", "Ribosomal protein S8 superfamily [IPR035987]", "Ribosomal protein S8e subdomain, eukaryotes [IPR042563]", "Ribosome maturation protein SBDS, N-terminal domain superfamily [IPR036786]", "Ribosome maturation protein Sdo1/SBDS, central domain superfamily [IPR037188]", "Ribosome-associated complex head domain superfamily [IPR042569]", "Ribulose-phosphate binding barrel [IPR011060]", "Ricin B-like lectins [IPR035992]", "RmlC-like cupin domain superfamily [IPR011051]", "RmlC-like jelly roll fold [IPR014710]", "Rossmann-like alpha/beta/alpha sandwich fold [IPR014729]", "Rudiment single hybrid motif [IPR011054]", "RutC-like superfamily [IPR035959]", "RuvA domain 2-like [IPR010994]", "RuvBL1/2, DNA/RNA binding domain [IPR042487]", "S-adenosyl-L-methionine-dependent methyltransferase [IPR029063]", "S-adenosylmethionine synthetase superfamily [IPR022636]", "S15/NS1, RNA-binding [IPR009068]", "SAP domain superfamily [IPR036361]", "SCAN domain superfamily [IPR038269]", "SCP2 sterol-binding domain superfamily [IPR036527]", "SGNH hydrolase superfamily [IPR036514]", "SH2 domain superfamily [IPR036860]", "SH3-like domain superfamily [IPR036028]", "SKP1-like, dimerisation domain superfamily [IPR036296]", "SKP1/BTB/POZ domain superfamily [IPR011333]", "SLED domain superfamily [IPR038348]", "SMAD/FHA domain superfamily [IPR008984]", "SMCs flexible hinge superfamily [IPR036277]", "SNARE [IPR010989]", "SNF2-like, N-terminal domain superfamily [IPR038718]", "SNase-like, OB-fold superfamily [IPR035437]", "SPOC-like, C-terminal domain superfamily [IPR016194]", "SRA-YDG superfamily [IPR036987]", "SRCR-like domain superfamily [IPR036772]", "SRP/SRP receptor, N-terminal [IPR036225]", "SRP68, N-terminal domain superfamily [IPR038253]", "SSRP1 domain superfamily [IPR038167]", "START-like domain superfamily [IPR023393]", "STAT transcription factor, DNA-binding, N-terminal [IPR012345]", "STAT transcription factor, N-terminal domain superfamily [IPR036535]", "STAT transcription factor, coiled coil [IPR015988]", "STAT1, C-terminal domain superfamily [IPR038295]", "SUI1 domain superfamily [IPR036877]", "SWAP/Surp superfamily [IPR035967]", "SWIB/MDM2 domain superfamily [IPR036885]", "Saposin-like [IPR011001]", "Scavenger mRNA decapping enzyme, N-terminal [IPR011145]", "Schlafen, AlbA_2 domain superfamily [IPR038461]", "ScpA-like, C-terminal [IPR023093]", "Sec1-like superfamily [IPR036045]", "Sec1-like, domain 1 [IPR043154]", "Sec1-like, domain 2 [IPR027482]", "Sec1-like, domain 3a [IPR043127]", "Sec23/Sec24 helical domain superfamily [IPR036175]", "Sec7 domain superfamily [IPR035999]", "Sec7, C-terminal domain superfamily [IPR023394]", "SecY domain superfamily [IPR023201]", "Serine carboxypeptidase S28, SKS domain [IPR042269]", "Serine-tRNA synthetase, type1, N-terminal domain superfamily [IPR042103]", "Serpin superfamily [IPR036186]", "Serpin superfamily, domain 1 [IPR042178]", "Serpin superfamily, domain 2 [IPR042185]", "Set2 Rpb1 interacting domain superfamily [IPR038190]", "Signal recognition particle SRP54, N-terminal domain superfamily [IPR042101]", "Signal recognition particle, SRP54 subunit, M-domain superfamily [IPR036891]", "Signal recognition particle, SRP9/SRP14 subunit [IPR009018]", "Sin3 associated polypeptide p18 superfamily [IPR042534]", "Single hybrid motif [IPR011053]", "Sirtuin, catalytic core small domain superfamily [IPR026591]", "Six-bladed beta-propeller, TolB-like [IPR011042]", "Six-hairpin glycosidase superfamily [IPR008928]", "Six-hairpin glycosidase-like superfamily [IPR012341]", "Smac/DIABLO-like superfamily [IPR009062]", "Sodium/potassium-transporting ATPase subunit beta superfamily [IPR038702]", "Sodium:dicarboxylate symporter superfamily [IPR036458]", "Spermidine synthase, tetramerisation domain superfamily [IPR037163]", "Spt6, Death-like domain [IPR042066]", "Stathmin superfamily [IPR036002]", "Sterile alpha motif/pointed domain superfamily [IPR013761]", "Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain superfamily [IPR027477]", "Succinyl-CoA synthetase-like [IPR016102]", "TAP42/TAP46-like superfamily [IPR038511]", "TBCC, N-terminal domain superfamily [IPR038397]", "TBP domain superfamily [IPR012295]", "TCP-1-like chaperonin intermediate domain superfamily [IPR027410]", "TEL2, C-terminal domain superfamily [IPR038528]", "TFIIS/LEDGF domain superfamily [IPR035441]", "TGS-like [IPR012676]", "TGS-like domain superfamily [IPR023192]", "TMEM14 superfamily [IPR044890]", "TRAF-like [IPR008974]", "TRF2-interacting telomeric protein/Rap1, C-terminal domain superfamily [IPR038104]", "TROVE domain superfamily [IPR037214]", "Talin, central domain superfamily [IPR036476]", "Tautomerase/MIF superfamily [IPR014347]", "Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid [IPR008930]", "Tetrapyrrole methylase superfamily [IPR035996]", "Tetrapyrrole methylase, subdomain 1 [IPR014777]", "Tetrapyrrole methylase, subdomain 2 [IPR014776]", "Tetraspanin, EC2 domain superfamily [IPR008952]", "Tetratricopeptide-like helical domain superfamily [IPR011990]", "Tex-like domain superfamily [IPR023323]", "Tex-like protein, HTH domain superfamily [IPR023319]", "Thiamin diphosphate-binding fold [IPR029061]", "Thiolase-like [IPR016039]", "Thioredoxin-like superfamily [IPR036249]", "Threonyl/alanyl tRNA synthetase, class II-like, putative editing domain superfamily [IPR018163]", "Thymidylate synthase/dCMP hydroxymethylase superfamily [IPR036926]", "Tim10-like domain superfamily [IPR035427]", "Tma16 superfamily [IPR038356]", "Transcription Factor IIF, Rap30/Rap74, interaction [IPR011039]", "Transcription elongation factor S-II, central domain superfamily [IPR036575]", "Transcription termination and cleavage factor, C-terminal domain superfamily [IPR038192]", "Transferrin receptor-like, dimerisation domain superfamily [IPR036757]", "Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II [IPR009014]", "Translation Initiation factor eIF- 4e-like [IPR023398]", "Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal [IPR009001]", "Translation elongation factor EF1B/ribosomal protein S6 [IPR014717]", "Translation elongation factor eEF-1beta-like superfamily [IPR036219]", "Translation initiation factor 2, alpha subunit, C-terminal [IPR024055]", "Translation initiation factor 2, alpha subunit, middle domain superfamily [IPR024054]", "Translation initiation factor 3, subunit 12, N-terminal, eukaryotic [IPR016020]", "Translation initiation factor IF-2, domain 3 superfamily [IPR036925]", "Translation initiation factor IF2/IF5, N-terminal [IPR016189]", "Translation initiation factor IF2/IF5, zinc-binding [IPR016190]", "Translation initiation factor eIF-2B subunit alpha, N-terminal [IPR042528]", "Translation protein SH3-like domain superfamily [IPR008991]", "Translation protein, beta-barrel domain superfamily [IPR009000]", "Translin superfamily [IPR036081]", "Translin, C-terminal [IPR016069]", "Translin, N-terminal [IPR016068]", "Trimeric LpxA-like superfamily [IPR011004]", "Triosephosphate isomerase superfamily [IPR035990]", "Tubulin binding cofactor A superfamily [IPR036126]", "Tubulin, C-terminal [IPR023123]", "Tubulin/FtsZ, C-terminal [IPR008280]", "Tubulin/FtsZ, GTPase domain superfamily [IPR036525]", "Tubulin/FtsZ-like, C-terminal domain [IPR037103]", "UBA-like superfamily [IPR009060]", "UDP-glucose/GDP-mannose dehydrogenase, C-terminal domain superfamily [IPR036220]", "UROD/MetE-like superfamily [IPR038071]", "Ubiquitin activating enzyme, alpha domain superfamily [IPR023318]", "Ubiquitin-activating enzyme E1, C-terminal domain superfamily [IPR038252]", "Ubiquitin-activating enzyme E1, FCCH domain superfamily [IPR042302]", "Ubiquitin-activating enzyme E1, SCCH domain [IPR042063]", "Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 1 [IPR042449]", "Ubiquitin-activating enzyme [IPR035985]", "Ubiquitin-conjugating enzyme/RWD-like [IPR016135]", "Ubiquitin-like domain superfamily [IPR029071]", "Ubiquitin-like modifier-activating enzyme Atg7, N-terminal, subdomain 1 [IPR042522]", "Ubiquitin-like modifier-activating enzyme Atg7, N-terminal, subdomain 2 [IPR042523]", "Ubiquitin-protein ligase E3A, N-terminal zinc-binding domain superfamily [IPR042556]", "Ufd1-like, Nn domain [IPR042299]", "Uracil-DNA glycosylase-like domain superfamily [IPR036895]", "Ureohydrolase domain superfamily [IPR023696]", "V-type ATP synthase c/d subunit, domain 3 superfamily [IPR044911]", "V-type ATP synthase subunit c/d subunit superfamily [IPR036079]", "V-type ATPase subunit C/d [IPR035067]", "V-type ATPase subunit E, C-terminal domain superfamily [IPR038495]", "VASP tetramerisation domain superfamily [IPR038023]", "VKOR domain superfamily [IPR038354]", "VPS9 domain superfamily [IPR037191]", "Vacuolar ATP synthase subunit C superfamily [IPR036132]", "Vacuolar protein sorting-associated protein 33, domain 3b [IPR043155]", "Vacuolar protein sorting-associated protein 35, C-terminal [IPR042491]", "Vacuolar protein sorting-associated protein IST1-like [IPR042277]", "Valyl-tRNA synthetase, tRNA-binding arm superfamily [IPR037118]", "Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain [IPR009008]", "Vanillyl-alcohol oxidase, C-terminal subdomain 2 [IPR016171]", "Vesicle transport v-SNARE, N-terminal domain superfamily [IPR038407]", "Vitamin B12-dependent methionine synthase, activation domain superfamily [IPR037010]", "Vps16, C-terminal domain superfamily [IPR038132]", "Vta1/Callose synthase, N-terminal domain superfamily [IPR023175]", "WD40-repeat-containing domain superfamily [IPR036322]", "WD40/YVTN repeat-like-containing domain superfamily [IPR015943]", "WGR domain superfamily [IPR036930]", "WW domain superfamily [IPR036020]", "WWE domain superfamily [IPR037197]", "Winged helix DNA-binding domain superfamily [IPR036390]", "Winged helix-like DNA-binding domain superfamily [IPR036388]", "XPC-binding domain superfamily [IPR036353]", "YEATS superfamily [IPR038704]", "YjeF N-terminal domain superfamily [IPR036652]", "YqgF/RNase H-like domain superfamily [IPR037027]", "ZPR1, A/B domain [IPR042451]", "ZPR1, zinc finger domain [IPR042452]", "Zinc finger C2H2 superfamily [IPR036236]", "Zinc finger, C2H2C-type superfamily [IPR036060]", "Zinc finger, CCCH-type superfamily [IPR036855]", "Zinc finger, CCHC-type superfamily [IPR036875]", "Zinc finger, FYVE/PHD-type [IPR011011]", "Zinc finger, NHR/GATA-type [IPR013088]", "Zinc finger, PARP-type superfamily [IPR036957]", "Zinc finger, RING/FYVE/PHD-type [IPR013083]", "Zinc finger, RanBP2-type superfamily [IPR036443]", "Zinc finger, Sec23/Sec24-type superfamily [IPR036174]", "Zinc finger, ZZ-type superfamily [IPR043145]", "Zinc-binding ribosomal protein [IPR011332]", "dUTPase-like superfamily [IPR036157]", "eRF1, domain 1 [IPR024049]", "eRF1, domain 2 superfamily [IPR042226]", "p53-like tetramerisation domain superfamily [IPR036674]", "p53-like transcription factor, DNA-binding [IPR008967]", "p53/RUNT-type transcription factor, DNA-binding domain superfamily [IPR012346]", "ssDNA-binding transcriptional regulator [IPR009044]", "tRNA (guanine-N1-)-methyltransferase, N-terminal [IPR029026]", "tRNA methyltransferase TRM10-type domain superfamily [IPR038459]", "tRNA methyltransferase, Trm1, C-terminal [IPR042296]", "tRNA modification GTPase MnmE domain 2 [IPR027368]", "tRNA-splicing ligase RtcB-like superfamily [IPR036025]", "von Willebrand factor A-like domain superfamily [IPR036465]"], "available_proteins": ["AAAS", "AAR2", "AARS", "AARS2", "AARSD1", "AASDHPPT", "AASS", "ABCB1", "ABCB10", "ABCB7", "ABCD3", "ABCE1", "ABCF1", "ABCF2", "ABHD10", "ABHD12", "ABHD14B", "ABHD6", "ACAA2", "ACACA", "ACACB", "ACAD9", "ACADM", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACBD5", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT8", "ACOT9", "ACOX1", "ACOX3", "ACP1", "ACP2", "ACP6", "ACSL1", "ACSL3", "ACSL4", "ACTN1", "ACTN2", "ACTN4", "ACTR10", "ACTR1A", "ACTR2", "ACTR3", "ADA", "ADAR", "ADD1", "ADD3", "ADH5", "ADI1", "ADK", "ADNP", "ADPGK", "ADPRHL2", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGK", "AGL", "AGPS", "AHCTF1", "AHCY", "AHCYL1", "AHNAK", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AK4", "AK6", "AKAP13", "AKR1A1", "AKR1B1", "AKR7A2", "AKT2", "ALDH18A1", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALKBH5", "ALYREF", "ANAPC1", "ANAPC4", "ANAPC5", "ANAPC7", "ANK3", "ANKFY1", "ANKHD1", "ANKLE2", "ANKRD50", "ANLN", "ANP32A", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP1M1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "APC", "APEH", "APEX1", "API5", "APMAP", "APP", "APPL1", "APRT", "AQR", "ARCN1", "ARF4", "ARF5", "ARFGAP1", "ARFIP1", "ARFIP2", "ARHGAP17", "ARHGDIA", "ARHGEF1", "ARHGEF2", "ARID1A", "ARID3B", "ARIH1", "ARL1", "ARL2", "ARL3", "ARL8B", "ARMC1", "ARMC6", "ARMC8", "ARMCX3", "ARMT1", "ARPC1A", "ARPC2", "ARPC3", "ARPC4", "ARPC5", "ASCC3", "ASF1A", "ASNA1", "ASNS", "ASPH", "ATAD1", "ATAD3A", "ATAD3B", "ATAD5", "ATE1", "ATG7", "ATIC", "ATL2", "ATP13A1", "ATP1A1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5H", "ATP5O", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1E1", "ATP6V1H", "ATXN10", "AURKA", "BABAM1", "BAG4", "BAG5", "BAG6", "BAIAP2", "BAK1", "BANF1", "BAP18", "BAZ1A", "BAZ1B", "BCAS3", "BCL2L13", "BCS1L", "BDH2", "BIRC6", "BLMH", "BLVRA", "BLVRB", "BMS1", "BOP1", "BPTF", "BRAT1", "BRD4", "BSG", "BTAF1", "BTF3", "BUB1", "BUB1B", "BUB3", "BZW1", "BZW2", "C1QBP", "CACYBP", "CAD", "CALM3", "CALR", "CALU", "CAMK2G", "CAND1", "CANX", "CAP1", "CAPN1", "CAPNS1", "CAPZA1", "CAPZB", "CARHSP1", "CARM1", "CARS", "CARS2", "CASK", "CASP3", "CASP6", "CASP7", "CASP8", "CBR1", "CBX1", "CBX3", "CBX5", "CBX8", "CCAR1", "CCAR2", "CCNB1", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2AP", "CD2BP2", "CD47", "CDC16", "CDC23", "CDC27", "CDC37", "CDC40", "CDC42", "CDC5L", "CDC73", "CDIPT", "CDK1", "CDK12", "CDK2", "CDK4", "CDK6", "CDX2", "CEBPZ", "CELF1", "CENPV", "CERS2", "CETN2", "CFL1", "CFL2", "CHAC2", "CHAF1B", "CHAMP1", "CHD1", "CHD4", "CHEK2", "CHERP", "CHID1", "CHKA", "CHML", "CHORDC1", "CHRAC1", "CIAPIN1", "CIP2A", "CIRBP", "CISD1", "CISD2", "CIZ1", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLCN3", "CLGN", "CLIC1", "CLIC4", "CLINT1", "CLNS1A", "CLPB", "CLPP", "CLPX", "CLTC", "CLUH", "CMPK1", "CMSS1", "CNN2", "CNN3", "CNNM4", "CNOT1", "CNOT7", "CNOT9", "CNP", "COA7", "COASY", "COLEC12", "COLGALT1", "COMT", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS2", "COPS3", "COPS4", "COPZ1", "COQ8A", "CORO1B", "CORO1C", "COTL1", "COX15", "COX2", "COX4I1", "COX5A", "COX5B", "COX6C", "COX7A2", "COX7C", "CPD", "CPNE1", "CPNE3", "CPOX", "CPPED1", "CPSF1", "CPSF2", "CPSF3", "CPSF6", "CPSF7", "CPT1A", "CPT2", "CPVL", "CRKL", "CRMP1", "CRNKL1", "CRTAP", "CRYZ", "CS", "CSDE1", "CSE1L", "CSK", "CSNK1A1", "CSNK2A2", "CSNK2B", "CSTF1", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTDSPL2", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTPS2", "CTR9", "CTSA", "CTSC", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4A", "CUL4B", "CUL5", "CUTA", "CWF19L1", "CXorf57", "CYB5B", "CYB5D2", "CYB5R3", "CYC1", "CYP20A1", "CYP51A1", "DAGLB", "DAP3", "DARS", "DARS2", "DAZAP1", "DBN1", "DBNL", "DCAF1", "DCAF13", "DCAF7", "DCAKD", "DCP1A", "DCPS", "DCTD", "DCTN1", "DCTN6", "DCUN1D4", "DCUN1D5", "DCXR", "DDB1", "DDI2", "DDRGK1", "DDT", "DDX1", "DDX10", "DDX17", "DDX18", "DDX20", "DDX21", "DDX23", "DDX24", "DDX27", "DDX28", "DDX39A", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX50", "DDX51", "DDX52", "DDX54", "DDX55", "DDX56", "DDX6", "DENR", "DERL1", "DFFA", "DHCR24", "DHFR", "DHPS", "DHRS7B", "DHX15", "DHX16", "DHX30", "DHX36", "DHX37", "DHX38", "DHX8", "DHX9", "DIABLO", "DIAPH1", "DIAPH3", "DICER1", "DIDO1", "DIEXF", "DIP2B", "DIS3", "DKC1", "DLAT", "DLD", "DLST", "DNAAF5", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC2", "DNAJC3", "DNAJC7", "DNAJC8", "DNAJC9", "DNM1L", "DNM2", "DNMT1", "DOCK7", "DOHH", "DOLPP1", "DPF2", "DPH2", "DPH5", "DPP9", "DPYSL2", "DPYSL3", "DRG1", "DRG2", "DSG2", "DSP", "DST", "DSTN", "DTL", "DTYMK", "DUSP3", "DUSP9", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNLL1", "DYNLL2", "EARS2", "ECE1", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "EDC3", "EDC4", "EDF1", "EEA1", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EEFSEC", "EFL1", "EFTUD2", "EHD1", "EHD4", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2D", "EIF2S1", "EIF2S2", "EIF3B", "EIF3E", "EIF3G", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "ELAC2", "ELAVL1", "ELOB", "ELOC", "ELP1", "ELP2", "ELP3", "EMC1", "EMC2", "EMD", "EMG1", "EML4", "ENAH", "ENDOD1", "ENO1", "EPB41", "EPB41L2", "EPB41L3", "EPHX1", "EPHX2", "EPPK1", "EPRS", "EPS15", "EPS15L1", "ERAL1", "ERAP1", "ERCC2", "ERCC3", "ERH", "ERLIN1", "ERLIN2", "ERO1A", "ERP29", "ERP44", "ESD", "ESF1", "ESYT1", "ESYT2", "ETF1", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXO1", "EXOC2", "EXOC7", "EXOSC10", "EXOSC3", "EXOSC4", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC8", "EZR", "F11R", "FABP5", "FADS2", "FAF1", "FAF2", "FAH", "FAHD1", "FAM120A", "FAR1", "FARSA", "FARSB", "FASN", "FBL", "FBXO22", "FBXO7", "FDFT1", "FDPS", "FDX1", "FDXR", "FEN1", "FERMT2", "FH", "FHOD1", "FIS1", "FKBP10", "FKBP14", "FKBP4", "FKBP5", "FKBP7", "FKBP8", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FMR1", "FN3KRP", "FNDC3A", "FNTB", "FOXC1", "FOXRED1", "FRYL", "FSCN1", "FTO", "FTSJ1", "FTSJ3", "FUBP1", "FUBP3", "FUCA1", "FUCA2", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GADD45GIP1", "GALK1", "GALNT2", "GALNT7", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2B", "GATB", "GATC", "GBA", "GBE1", "GBF1", "GCAT", "GCDH", "GCLM", "GCN1", "GDAP1", "GDI1", "GDI2", "GDPD1", "GEMIN5", "GET4", "GFM1", "GFPT1", "GGA1", "GGCT", "GGCX", "GGH", "GIGYF2", "GINS2", "GINS3", "GINS4", "GLA", "GLB1", "GLDC", "GLO1", "GLOD4", "GLRX3", "GLRX5", "GLS", "GLUD1", "GLYR1", "GM2A", "GMDS", "GMFB", "GMPPA", "GMPPB", "GMPS", "GNA13", "GNAI1", "GNAI2", "GNAI3", "GNL1", "GNL2", "GNL3", "GNL3L", "GNPDA1", "GNS", "GOLPH3", "GORASP2", "GOT1", "GOT2", "GPATCH8", "GPD2", "GPHN", "GPI", "GPKOW", "GPS1", "GPT2", "GPX8", "GRB2", "GRHPR", "GRPEL1", "GRSF1", "GRWD1", "GSK3A", "GSK3B", "GSPT1", "GSR", "GSS", "GSTK1", "GSTM3", "GSTO1", "GSTZ1", "GTF2B", "GTF2E1", "GTF2F1", "GTF2F2", "GTF2I", "GTF3C2", "GTF3C3", "GTPBP1", "GTPBP10", "GTPBP3", "GTPBP4", "GUSB", "GYG1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACD3", "HADH", "HADHA", "HADHB", "HAT1", "HBS1L", "HCFC1", "HDAC2", "HDGFL2", "HDHD2", "HDHD3", "HDHD5", "HDLBP", "HEATR1", "HEATR3", "HEATR6", "HEBP1", "HECTD1", "HELLS", "HEXA", "HEXB", "HGH1", "HGS", "HIBADH", "HIBCH", "HINT2", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HLTF", "HMBS", "HMGB1", "HMGB2", "HMGB3", "HMGCL", "HMGCS1", "HMOX1", "HMOX2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HNRNPUL2", "HOOK3", "HP1BP3", "HPRT1", "HS2ST1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSDL1", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA14", "HSPA1B", "HSPA2", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPB1", "HSPBP1", "HSPD1", "HSPE1", "HSPH1", "HTATSF1", "HTT", "HUWE1", "HYOU1", "IARS", "IARS2", "IBA57", "IDE", "IDI1", "IFIT5", "IFT27", "IGBP1", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "ILF2", "ILF3", "ILK", "ILKAP", "ILVBL", "IMP3", "IMPDH1", "IMPDH2", "INF2", "INTS14", "INTS7", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IRS4", "ISOC1", "IST1", "ISYNA1", "ITCH", "ITGB1", "ITPA", "IVD", "IWS1", "JUP", "KARS", "KAT7", "KCTD12", "KCTD5", "KDELC2", "KDM1A", "KDM1B", "KDM2A", "KDSR", "KHDRBS1", "KHDRBS3", "KHSRP", "KIAA0319L", "KIAA0368", "KIAA1468", "KIF11", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF3A", "KIF4A", "KIF5B", "KIFBP", "KIFC1", "KLC1", "KLC2", "KLC4", "KPNA1", "KPNA2", "KPNA3", "KPNA6", "KPNB1", "KYAT3", "L1RE1", "L2HGDH", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LASP1", "LDHA", "LDHB", "LDLR", "LEMD2", "LEMD3", "LETM1", "LGALS3", "LGALS3BP", "LIG1", "LIG3", "LIPA", "LLGL1", "LMAN1", "LMAN2", "LMNA", "LMNB1", "LMNB2", "LNPEP", "LONP1", "LPCAT1", "LRBA", "LRPAP1", "LRPPRC", "LRRC40", "LRRC47", "LRRC57", "LRRC59", "LSM6", "LSM7", "LSM8", "LSS", "LTA4H", "LYAR", "LYPLA1", "LZIC", "M6PR", "MACF1", "MAD2L1", "MAGED2", "MAGT1", "MAP2K1", "MAP2K2", "MAP2K3", "MAPK1", "MAPK14", "MAPRE1", "MAPRE2", "MARC1", "MARS", "MARS2", "MASTL", "MAT2A", "MAT2B", "MATR3", "MAU2", "MAVS", "MCAT", "MCCC1", "MCCC2", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCTS1", "MDC1", "MDH1", "MDH2", "MDN1", "ME2", "MECP2", "METAP1", "METTL13", "MFN1", "MFN2", "MFSD5", "MGEA5", "MGME1", "MGST2", "MGST3", "MIA2", "MIA3", "MICU1", "MICU2", "MID1", "MIF", "MINPP1", "MIOS", "MIPEP", "MKI67", "MMAB", "MMS19", "MOGS", "MON2", "MORF4L1", "MOSPD2", "MOV10", "MPI", "MPP1", "MPP2", "MPP6", "MPRIP", "MPST", "MRC2", "MRE11", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL14", "MRPL15", "MRPL17", "MRPL19", "MRPL20", "MRPL21", "MRPL38", "MRPL39", "MRPL43", "MRPL44", "MRPL45", "MRPL47", "MRPL48", "MRPL9", "MRPS15", "MRPS17", "MRPS2", "MRPS25", "MRPS27", "MRPS5", "MRPS7", "MRPS9", "MRTO4", "MSH2", "MSH3", "MSH6", "MSI1", "MSN", "MSTO1", "MTA1", "MTA2", "MTAP", "MTCH1", "MTCH2", "MTHFD1", "MTHFD1L", "MTHFD2", "MTOR", "MTPAP", "MTPN", "MTR", "MTX1", "MTX2", "MUT", "MYBBP1A", "MYEF2", "MYH10", "MYH14", "MYH9", "MYL6", "MYO1B", "MYO1D", "MYO6", "NAA10", "NAA15", "NAA25", "NAA40", "NAA50", "NADK2", "NAE1", "NAF1", "NAGK", "NAGLU", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NAPG", "NARS", "NASP", "NAT10", "NAXE", "NBN", "NCAPD2", "NCAPG", "NCBP1", "NCBP2", "NCDN", "NCL", "NCOA5", "NDRG3", "NDUFA10", "NDUFA2", "NDUFA9", "NDUFAF7", "NDUFS1", "NDUFS3", "NDUFV1", "NDUFV2", "NECAP2", "NEK9", "NELFE", "NENF", "NFKB1", "NFS1", "NHLRC2", "NHP2", "NIFK", "NIP7", "NIPSNAP2", "NISCH", "NKRF", "NKTR", "NLE1", "NLN", "NME1", "NME2", "NMT1", "NNT", "NOC2L", "NOC3L", "NOC4L", "NOL10", "NOL11", "NOL8", "NOL9", "NONO", "NOP10", "NOP2", "NOP56", "NOP58", "NOP9", "NOSIP", "NPEPPS", "NPLOC4", "NPM1", "NRBP1", "NRDC", "NSD2", "NSDHL", "NSF", "NSFL1C", "NSUN2", "NSUN5", "NT5C2", "NT5C3B", "NT5DC1", "NT5DC2", "NTMT1", "NTPCR", "NUB1", "NUBP2", "NUBPL", "NUCB1", "NUCB2", "NUDC", "NUDCD1", "NUDCD2", "NUDT1", "NUDT21", "NUDT5", "NUDT9", "NUP133", "NUP153", "NUP155", "NUP188", "NUP210", "NUP214", "NUP35", "NUP37", "NUP50", "NUP98", "NUTF2", "NVL", "NXF1", "NXN", "OAT", "OCLN", "OGDH", "OGT", "OLA1", "OPA1", "OSBP", "OSBPL11", "OSBPL6", "OSBPL8", "OSBPL9", "OSGEP", "OTUB1", "P3H1", "P3H4", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PACSIN3", "PAFAH1B1", "PAFAH1B3", "PAK1", "PAK1IP1", "PAK2", "PALLD", "PANK4", "PAPSS1", "PARK7", "PARN", "PARP1", "PARP2", "PASK", "PBDC1", "PBK", "PBRM1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCID2", "PCK2", "PCMT1", "PCYOX1", "PDCD11", "PDCD4", "PDCD5", "PDCD6", "PDCD6IP", "PDCL3", "PDE12", "PDE6D", "PDHA1", "PDHB", "PDIA3", "PDIA4", "PDIA6", "PDK3", "PDLIM1", "PDLIM5", "PDLIM7", "PDS5A", "PDS5B", "PDXK", "PEBP1", "PECR", "PEF1", "PELO", "PELP1", "PEPD", "PES1", "PEX14", "PEX19", "PEX5", "PFAS", "PFDN2", "PFDN4", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGP", "PGRMC1", "PGRMC2", "PHB", "PHB2", "PHF6", "PHF8", "PHGDH", "PI4KB", "PICALM", "PIK3C3", "PIN1", "PIP4K2C", "PIR", "PITHD1", "PITPNA", "PITPNB", "PITRM1", "PKM", "PKMYT1", "PKN1", "PKN2", "PLA2G15", "PLAA", "PLBD2", "PLCG1", "PLEC", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLRG1", "PLS3", "PM20D2", "PMPCA", "PMPCB", "PNO1", "PNP", "PNPLA8", "PNPT1", "POGZ", "POLA1", "POLA2", "POLD1", "POLDIP2", "POLDIP3", "POLE", "POLE3", "POLE4", "POLR1A", "POLR1B", "POLR1C", "POLR2A", "POLR2B", "POLR2C", "POLR2E", "POLR2G", "POLR2L", "POLR3A", "POLRMT", "PON2", "POR", "PPA1", "PPA2", "PPAT", "PPFIA1", "PPIB", "PPID", "PPIE", "PPIF", "PPIH", "PPIL1", "PPIL4", "PPM1G", "PPME1", "PPOX", "PPP1CA", "PPP1CB", "PPP1R10", "PPP1R12A", "PPP1R7", "PPP1R8", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP4R3A", "PPP5C", "PPP6C", "PPT1", "PPT2", "PQBP1", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PREP", "PREPL", "PRKACA", "PRKAR1A", "PRKAR2A", "PRKCSH", "PRKDC", "PRMT1", "PRMT3", "PRMT5", "PRMT9", "PRPF19", "PRPF3", "PRPF31", "PRPF39", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPS2", "PRPSAP1", "PRPSAP2", "PRRC1", "PSAP", "PSAT1", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD12", "PSMD13", "PSMD2", "PSMD3", "PSMD4", "PSMD6", "PSME1", "PSME2", "PSME3", "PSME4", "PSPC1", "PTBP1", "PTBP2", "PTCD1", "PTCD3", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK7", "PTPA", "PTPN1", "PTRH2", "PTRHD1", "PUF60", "PUM1", "PUM3", "PUS7", "PWP1", "PWP2", "PYCR1", "PYCR2", "QARS", "QDPR", "QKI", "QRSL1", "RAB10", "RAB11B", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB1B", "RAB24", "RAB34", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RAB8A", "RAB8B", "RAB9A", "RABEPK", "RABGAP1", "RAC1", "RACK1", "RAD21", "RAD23A", "RAD23B", "RAD50", "RAE1", "RAI14", "RALA", "RALB", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP9", "RANGAP1", "RAP1GDS1", "RAPGEF2", "RARS", "RARS2", "RAVER1", "RBBP5", "RBBP6", "RBM10", "RBM12", "RBM12B", "RBM14", "RBM17", "RBM19", "RBM22", "RBM25", "RBM26", "RBM27", "RBM28", "RBM3", "RBM34", "RBM39", "RBM4", "RBM42", "RBM4B", "RBM5", "RBM8A", "RBMX", "RBMXL1", "RBPMS", "RCC1", "RCC2", "RCL1", "RCN1", "RCN2", "RDH11", "RDH13", "RDH14", "RDX", "RECQL", "REPS1", "RETSAT", "REXO2", "REXO4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RFX1", "RHEB", "RHOA", "RHOG", "RHOT1", "RIC8A", "RIDA", "RIF1", "RINT1", "RIPK1", "RMDN1", "RNASEH2A", "RNASET2", "RNF14", "RNF20", "RNF219", "RNF40", "RNH1", "RNPEP", "RNPS1", "ROCK2", "RP2", "RPA1", "RPA2", "RPAP3", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL27", "RPL27A", "RPL3", "RPL30", "RPL31", "RPL32", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPP30", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS28", "RPS3", "RPS4X", "RPS5", "RPS6KA1", "RPS6KA3", "RPS8", "RPS9", "RPSA", "RRM1", "RRM2", "RRP12", "RRP8", "RSF1", "RSL1D1", "RSU1", "RTCB", "RTN4IP1", "RUFY1", "RUVBL1", "RUVBL2", "S100A10", "S100A11", "S100A13", "SAE1", "SAFB", "SAFB2", "SAMHD1", "SAP18", "SAR1A", "SARNP", "SARS", "SARS2", "SART3", "SBDS", "SCAF4", "SCCPDH", "SCFD1", "SCML2", "SCO1", "SCO2", "SCP2", "SCPEP1", "SCRIB", "SDF4", "SDHA", "SDHB", "SEC11A", "SEC22B", "SEC23A", "SEC23B", "SEC23IP", "SEC24A", "SEC24B", "SEC24C", "SEC31A", "SEC61A1", "SEC63", "SEH1L", "SEL1L", "SENP3", "SEPHS1", "SEPT11", "SEPT2", "SEPT7", "SEPT9", "SERPINB6", "SERPINH1", "SET", "SETD2", "SF1", "SF3A1", "SF3A2", "SF3B1", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFSWAP", "SGPL1", "SGTA", "SH3BGRL3", "SH3GL1", "SH3GLB1", "SH3GLB2", "SHCBP1", "SHMT1", "SHMT2", "SHOC2", "SIRT1", "SKIV2L", "SKIV2L2", "SKP1", "SKP2", "SLC16A1", "SLC19A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A17", "SLC25A20", "SLC25A22", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A33", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A4", "SLC29A1", "SLC2A1", "SLC33A1", "SLC3A2", "SLC9A3R1", "SLFN11", "SLIRP", "SLIT2", "SLK", "SLTM", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCC1", "SMARCC2", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC6", "SMCHD1", "SMU1", "SMYD3", "SMYD4", "SND1", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPC", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNU13", "SNX1", "SNX12", "SNX17", "SNX2", "SNX27", "SNX3", "SNX5", "SNX6", "SNX9", "SOD2", "SON", "SORD", "SORT1", "SPAG9", "SPART", "SPATA5L1", "SPECC1L", "SPEN", "SPOUT1", "SPR", "SPTAN1", "SPTBN1", "SPTBN2", "SPTLC1", "SPTLC2", "SQLE", "SQSTM1", "SREK1", "SRI", "SRM", "SRP14", "SRP54", "SRP68", "SRP72", "SRP9", "SRPK1", "SRPRA", "SRPRB", "SRRM1", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF3", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSRP1", "STAG1", "STAG2", "STAM", "STARD3", "STARD7", "STAT1", "STAT3", "STIP1", "STK4", "STMN1", "STOM", "STOML2", "STRAP", "STRBP", "STRN", "STUB1", "STX12", "STX5", "STX7", "STXBP3", "STXBP4", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGP2", "SUGT1", "SUPT16H", "SUPT5H", "SUPT6H", "SUPV3L1", "SV2A", "SYAP1", "SYMPK", "SYNCRIP", "SYNE2", "SYNJ2BP", "TAF15", "TAGLN2", "TALDO1", "TARDBP", "TARS", "TARS2", "TBC1D10B", "TBC1D13", "TBC1D15", "TBC1D4", "TBC1D9B", "TBCA", "TBCC", "TBCD", "TBCE", "TBL3", "TCAF1", "TCEA1", "TCERG1", "TCP1", "TDP2", "TDRKH", "TECR", "TELO2", "TERF2IP", "TEX10", "TEX264", "TFAM", "TFCP2", "TFRC", "THOC1", "THOC3", "THOC6", "THOP1", "THUMPD3", "TIA1", "TIAL1", "TIGAR", "TIMM10", "TIMM44", "TIMM50", "TIMM8B", "TJP1", "TK1", "TKFC", "TKT", "TLN1", "TMA16", "TMED2", "TMED5", "TMED7", "TMEM14C", "TMOD1", "TMOD3", "TMPO", "TMPO", "TMTC3", "TMX1", "TMX2", "TMX3", "TMX4", "TNPO1", "TNPO2", "TNPO3", "TOE1", "TOLLIP", "TOMM20", "TOMM34", "TOMM40", "TOMM70", "TOP1", "TOP2A", "TOP2B", "TOR1AIP1", "TOX4", "TP53", "TP53BP1", "TPD52L2", "TPI1", "TPM4", "TPP1", "TPP2", "TPT1", "TRA2A", "TRA2B", "TRAP1", "TRAPPC5", "TRIM21", "TRIM24", "TRIM25", "TRIM26", "TRIM27", "TRIM28", "TRIM33", "TRIM35", "TRIP12", "TRIP13", "TRMT10C", "TRMT1L", "TROVE2", "TSFM", "TSG101", "TSN", "TSNAX", "TSPAN3", "TSPAN6", "TTC1", "TTC19", "TTC26", "TTC37", "TTC38", "TTC4", "TTF2", "TUBB", "TUBB2A", "TUBB2B", "TUBB4A", "TUBB4B", "TUBB6", "TUBGCP2", "TUBGCP3", "TUFM", "TWF1", "TWF2", "TXNDC12", "TXNDC17", "TXNDC5", "TXNL1", "TXNRD1", "TYMS", "U2AF1", "U2AF2", "U2SURP", "UAP1", "UBA1", "UBA2", "UBA3", "UBA6", "UBAP2", "UBAP2L", "UBE2G2", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2O", "UBE2S", "UBE3A", "UBE4B", "UBFD1", "UBLCP1", "UBQLN4", "UBR4", "UBR5", "UBTF", "UBXN1", "UCHL5", "UFC1", "UFD1", "UFM1", "UGDH", "UGGT1", "UGP2", "UHRF1", "UMPS", "UNC119", "UNC119B", "UNC45A", "UNG", "UPF1", "UQCR10", "UQCRB", "UQCRC1", "UQCRC2", "UQCRQ", "URB1", "UROD", "USO1", "USP10", "USP11", "USP14", "USP15", "USP39", "USP47", "USP48", "USP5", "USP7", "USP9X", "UTP15", "UTP18", "UTP20", "UTP4", "UTP6", "UTRN", "VAMP7", "VAPA", "VAPB", "VARS1", "VARS2", "VAT1", "VBP1", "VCL", "VCP", "VDAC1", "VDAC2", "VDAC3", "VIPAS39", "VIRMA", "VKORC1L1", "VPS26A", "VPS29", "VPS33A", "VPS33B", "VPS35", "VPS4B", "VRK1", "VTA1", "VTI1B", "WAPL", "WARS", "WDHD1", "WDR1", "WDR18", "WDR3", "WDR36", "WDR41", "WDR43", "WDR46", "WDR5", "WDR6", "WDR61", "WDR75", "WDR77", "WDR82", "WDR91", "WFS1", "WIPI2", "WIZ", "WNK1", "XAB2", "XPNPEP1", "XPNPEP3", "XPO1", "XPO5", "XPO7", "XPOT", "XRCC1", "XRCC5", "XRCC6", "YARS", "YARS2", "YBX1", "YBX3", "YEATS4", "YKT6", "YLPM1", "YME1L1", "YRDC", "YTHDC2", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2", "ZC3H15", "ZC3H18", "ZC3H7A", "ZC3HAV1", "ZCCHC3", "ZFR", "ZFYVE16", "ZNF24", "ZNF281", "ZNF622", "ZNF638", "ZPR1"], "leading_proteins": ["AARS2", "ABCB1", "ABCB7", "ACOT8", "ACOT9", "ACOX1", "ACOX3", "ADD1", "ADK", "AHCYL1", "AKT2", "ANAPC5", "ANKLE2", "ARHGAP17", "ARMT1", "ARPC2", "ATE1", "ATP13A1", "ATP2A2", "BLVRB", "CALU", "CAMK2G", "CARM1", "CASK", "CDK4", "CHID1", "CHKA", "CLGN", "CLUH", "COA7", "COMT", "COPG1", "CRNKL1", "CRTAP", "CSNK1A1", "CTBP1", "CWF19L1", "CYB5B", "CYB5D2", "CYP51A1", "DAZAP1", "DCUN1D4", "DICER1", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC2", "DNAJC3", "DNAJC7", "DNAJC8", "DRG1", "DUSP9", "ECE1", "EIF4B", "EWSR1", "EXOSC3", "FKBP14", "FKBP7", "FLAD1", "FMR1", "FUBP1", "FUBP3", "FUCA2", "FUS", "GALNT7", "GBA", "GINS2", "GINS4", "GLUD1", "GRSF1", "GUSB", "HADH", "HADHA", "HAT1", "HDGFL2", "HDHD3", "HDHD5", "HEXA", "HINT2", "HMOX2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPM", "HNRNPR", "HNRNPUL1", "HNRNPUL2", "HSD17B12", "HSD17B4", "HSDL1", "HSDL2", "IBA57", "IFIT5", "IGF2BP2", "IGF2BP3", "ILVBL", "ITCH", "KAT7", "KDSR", "KHDRBS1", "KHDRBS3", "KHSRP", "KIFBP", "KLC2", "LARP4", "LDLR", "LETM1", "LMNA", "LMNB2", "LRBA", "LSS", "LTA4H", "MAP2K2", "MAPRE1", "MATR3", "MCL1", "METTL13", "MGEA5", "MIPEP", "MOGS", "MPP1", "MPP2", "MPP6", "MRC2", "MRPL15", "MRPL39", "MSI1", "MTCH1", "MTX1", "MTX2", "MYEF2", "NAA10", "NAGLU", "NAP1L4", "NDUFAF7", "NLN", "NNT", "NONO", "NPEPPS", "NRDC", "NSUN2", "NT5C3B", "NT5DC2", "NUB1", "NUCB1", "NUCB2", "OCLN", "OSBPL6", "P3H1", "P3H4", "P4HA1", "PABPC4", "PAK1", "PARN", "PDE6D", "PECR", "PEX5", "PFDN2", "PFDN4", "PFDN6", "PGRMC2", "PIK3C3", "PIR", "PITRM1", "PKMYT1", "PMPCA", "PNPT1", "PPAT", "PRMT9", "PSMA5", "PSMA6", "PSMB1", "PSMB2", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMD3", "PUF60", "RAD23A", "RARS2", "RAVER1", "RBM10", "RBM14", "RBM27", "RBM3", "RBM4", "RBM4B", "RBMX", "RBPMS", "RCN2", "RIPK1", "RMDN1", "RNPS1", "RPL27A", "RPL37", "RPS20", "RTN4IP1", "SCCPDH", "SDF4", "SDHB", "SEC63", "SEL1L", "SET", "SF1", "SFPQ", "SLC19A1", "SLC25A10", "SLC25A11", "SLC25A20", "SLC25A26", "SLC25A32", "SLC2A1", "SLC3A2", "SMYD4", "SNRNP70", "SRM", "SRSF1", "SRSF3", "SRSF7", "SRSF9", "STX5", "STX7", "SV2A", "SYNCRIP", "TAF15", "TARS2", "TBCE", "TEX264", "TIA1", "TIAL1", "TMPO", "TRA2A", "TRA2B", "TRIM26", "TRIM27", "TSPAN3", "TTC26", "TTC38", "TUBGCP2", "UBE3A", "UBR5", "UNC119B", "UQCRC2", "USP11", "USP15", "VAPA", "VAT1", "VBP1", "VDAC1", "VDAC2", "VDAC3", "VTI1B", "WFS1", "YME1L1", "YTHDC2", "ZADH2", "ZCCHC3"]} \ No newline at end of file diff --git a/interpro_ptm/advanced/idx2term.json b/interpro_ptm/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..9e26dfeeb6e641a33dae4961196235bdb965b21b --- /dev/null +++ b/interpro_ptm/advanced/idx2term.json @@ -0,0 +1 @@ +{} \ No newline at end of file diff --git a/interpro_ptm/basic/idx2term.json b/interpro_ptm/basic/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..9e26dfeeb6e641a33dae4961196235bdb965b21b --- /dev/null +++ b/interpro_ptm/basic/idx2term.json @@ -0,0 +1 @@ +{} \ No newline at end of file diff --git a/interpro_ptm/consensus.joblib b/interpro_ptm/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..16ba37ff242fd41468581f2be96a411a81f71fef --- /dev/null +++ b/interpro_ptm/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:d12161bcccce4e305b156c4df21000dcecb5e7baa3efaedadfa4cd6a4fdba4c3 +size 61160 diff --git a/interpro_ptm/df_merge.tsv b/interpro_ptm/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..c57981107d970e936c6c67aa07afef8fff633223 --- /dev/null +++ b/interpro_ptm/df_merge.tsv @@ -0,0 +1 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 diff --git a/interpro_ptm/metrics.json b/interpro_ptm/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..707660734ace89786b63409d6c16aed8fab9aa40 --- /dev/null +++ b/interpro_ptm/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2734, + "annotations_size": 4, + "title": "Average number of proteins per term", + "value": 2.0 +} \ No newline at end of file diff --git a/interpro_ptm/paths.json b/interpro_ptm/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..20891744abd05c538cbfa011d00c4481710e9463 --- /dev/null +++ b/interpro_ptm/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/interpro_ptm/fragment/C166/C166_val_log2fc"} \ No newline at end of file diff --git a/interpro_ptm/result.tsv b/interpro_ptm/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..8646dcb6f26960577db2d17169196c1bdaf949c5 --- /dev/null +++ b/interpro_ptm/result.tsv @@ -0,0 +1,2 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +P-type ATPase, phosphorylation site [IPR018303] 0.8122437610377673 1.7486779738223428 0.0803466994978006 0.2846863126810859 0.1071289326637341 4 Q9HD20 1 diff --git a/interpro_ptm/selections.json b/interpro_ptm/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..e52a2743c5eed7bc23edc8fe15ae270842fbd1fd --- /dev/null +++ b/interpro_ptm/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["EGF-type aspartate/asparagine hydroxylation site [IPR000152]", "P-type ATPase, phosphorylation site [IPR018303]", "Phosphopantetheine attachment site [IPR006162]", "Translation elongation factor, IF5A, hypusine site [IPR019769]"], "available_proteins": ["ATP13A1", "ATP1A1", "ATP2A2", "ATP2B1", "EIF5A", "FASN", "LDLR", "SLIT2"], "leading_proteins": ["ATP13A1"]} \ No newline at end of file diff --git a/interpro_repeat/advanced/idx2term.json b/interpro_repeat/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..6dce773863970e13dd9ed6c0019ab4c4e97de280 --- /dev/null +++ b/interpro_repeat/advanced/idx2term.json @@ -0,0 +1 @@ +{"0": "Mitochondrial substrate/solute carrier [IPR018108]"} \ No newline at end of file diff --git a/interpro_repeat/advanced/plot_0.png b/interpro_repeat/advanced/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..8945f5d75e9c95498c6d33b562ea7eecc0e64bcd --- /dev/null +++ b/interpro_repeat/advanced/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:8cabf211fd47a70b48b528b7d4e38287dc1d7164e618f92a5af75a7187d6e38f +size 188562 diff --git a/interpro_repeat/basic/idx2term.json b/interpro_repeat/basic/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..6dce773863970e13dd9ed6c0019ab4c4e97de280 --- /dev/null +++ b/interpro_repeat/basic/idx2term.json @@ -0,0 +1 @@ +{"0": "Mitochondrial substrate/solute carrier [IPR018108]"} \ No newline at end of file diff --git a/interpro_repeat/basic/plot_0.png b/interpro_repeat/basic/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..425b88a88c4f4a71dca44a7c57d95bdb6769ec78 --- /dev/null +++ b/interpro_repeat/basic/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:bb34c6e3dda962878f7869a4897c80a8b94436e1bcaa5b6800da49338f67fc20 +size 146313 diff --git a/interpro_repeat/consensus.joblib b/interpro_repeat/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..e1dfe75456f834ff10e8ef27ebb7140fc4865f71 --- /dev/null +++ b/interpro_repeat/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:1cb77ee97a97a12091d3559ff67adced2057ef3882e96e662894c55e2937827f +size 79418 diff --git a/interpro_repeat/df_merge.tsv b/interpro_repeat/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..9b79fbd2a3eac96317a2702395e17590d301860a --- /dev/null +++ b/interpro_repeat/df_merge.tsv @@ -0,0 +1,2 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Mitochondrial substrate/solute carrier [IPR018108] 6 19 2.8776718101364187 0.0040062168704588 9.148058252427184 20.71359223300971 2.0411027534642088 0.1411881998864352 5.368907349966936 1.8276489510009888 1.309103123363054 0.2428184236965967 5.775152660265721e-05 0.0142466262053111 0.0058560324261939 0.000273959679835 0.0004032504678998 diff --git a/interpro_repeat/metrics.json b/interpro_repeat/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..82e72540ecf2610fb1192c0af605a3a29b42be83 --- /dev/null +++ b/interpro_repeat/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2734, + "annotations_size": 78, + "title": "Average number of proteins per term", + "value": 4.948717948717949 +} \ No newline at end of file diff --git a/interpro_repeat/paths.json b/interpro_repeat/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..9ca6779426de5eeedf29fb121b14d4b0cf183098 --- /dev/null +++ b/interpro_repeat/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/interpro_repeat/fragment/C166/C166_val_log2fc"} \ No newline at end of file diff --git a/interpro_repeat/result.tsv b/interpro_repeat/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..f504d926b95602e9c23c79ba4787bc5295d1dc4b --- /dev/null +++ b/interpro_repeat/result.tsv @@ -0,0 +1,7 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Mitochondrial substrate/solute carrier [IPR018108] 0.6974447357963988 2.8776718101364187 0.0040062168704588 0.2688323731885501 0.0097651536217435 19 Q70HW3,Q9NZJ7,O43772,Q9UBX3,Q9H2D1,Q02978 6 +Sel1-like repeat [IPR006597] 0.7931918008784747 2.478831364506658 0.0131813609900315 0.6447673958829234 0.026362721980063 2 Q96BR5 1 +Kinesin light chain repeat [IPR015792] 0.7014225690722845 1.6187166718019603 0.1055082380835599 0.9998329082827327 0.1470245524360096 3 Q9H0B6 1 +Low-density lipoprotein (LDL) receptor class A repeat [IPR002172] 0.5131771595900537 1.0452124453649605 0.2959247927174777 0.9999999999986988 0.3615581513276507 2 P01130 1 +HEAT repeat [IPR000357] 0.584448534947735 0.7766949588892602 0.4373387617535034 1.0 0.4737836585662953 5 Q8TEX9,O00410 2 +Hexapeptide repeat [IPR001451] 0.3129772395580818 0.0039267627572804 0.9968669046738085 1.0 1.0 4 Q9Y5P6 1 diff --git a/interpro_repeat/selections.json b/interpro_repeat/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..02608d758defaf7d35ab5633435a32ed85e6efbc --- /dev/null +++ b/interpro_repeat/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["Adenomatous polyposis coli (APC) repeat [IPR041257]", "Adenomatous polyposis coli protein repeat [IPR009223]", "Adenomatous polyposis coli protein, 15 residue repeat [IPR009240]", "Ankyrin repeat [IPR002110]", "Annexin repeat [IPR018502]", "Armadillo [IPR000225]", "Atypical Arm repeat [IPR032413]", "BIR repeat [IPR001370]", "Calponin repeat [IPR000557]", "Cation-independent mannose-6-phosphate receptor repeat [IPR000479]", "Chromosome region maintenance repeat [IPR041123]", "Clathrin, heavy chain, propeller repeat [IPR022365]", "Clathrin, heavy chain/VPS, 7-fold repeat [IPR000547]", "Collagen triple helix repeat [IPR008160]", "Cysteine-rich Golgi apparatus protein 1 repeat [IPR001893]", "Cysteine-rich Golgi apparatus protein 1 repeat, eukaryote [IPR017873]", "Exportin-1, repeat 2 [IPR041235]", "Exportin-1, repeat 3 [IPR040485]", "Filamin/ABP280 repeat [IPR001298]", "Filamin/ABP280 repeat-like [IPR017868]", "Fis1, C-terminal tetratricopeptide repeat [IPR028061]", "Fis1, N-terminal tetratricopeptide repeat [IPR028058]", "G-protein beta WD-40 repeat [IPR020472]", "GTF2I-like repeat [IPR004212]", "HAT (Half-A-TPR) repeat [IPR003107]", "HEAT repeat [IPR000357]", "HEAT, type 2 [IPR021133]", "HUWE1/Rev1, ubiquitin binding region [IPR025527]", "Hexapeptide repeat [IPR001451]", "Hs1/Cortactin [IPR003134]", "Huntingtin, middle-repeat [IPR024613]", "Importin repeat 4 [IPR041653]", "Importin repeat 6 [IPR041389]", "Importin repeat [IPR040928]", "KI67R [IPR012568]", "Kelch repeat type 1 [IPR006652]", "Kelch repeat type 2 [IPR011498]", "Kinesin light chain repeat [IPR015792]", "LDLR class B repeat [IPR000033]", "Leucine rich repeat 4 [IPR025875]", "Leucine-rich repeat [IPR001611]", "Leucine-rich repeat, cysteine-containing subtype [IPR006553]", "Leucine-rich repeat, typical subtype [IPR003591]", "Low-density lipoprotein (LDL) receptor class A repeat [IPR002172]", "Mbt repeat [IPR004092]", "Microtubule associated protein, tubulin-binding repeat [IPR001084]", "Mitochondrial substrate/solute carrier [IPR018108]", "NHL repeat [IPR001258]", "Nebulin repeat [IPR000900]", "Neuraxin/MAP1B repeat [IPR000102]", "P120R repeat [IPR012586]", "PBS lyase HEAT-like repeat [IPR004155]", "PFTB repeat [IPR001330]", "PQ-loop repeat [IPR006603]", "Parallel beta-helix repeat [IPR006626]", "Pentatricopeptide repeat [IPR002885]", "Plectin repeat [IPR001101]", "Proteasome/cyclosome repeat [IPR002015]", "Protein of unknown function DM15 [IPR006607]", "Proteinase inhibitor I27, calpastatin [IPR001259]", "Pumilio RNA-binding repeat [IPR001313]", "Putative TPR-like repeat [IPR031545]", "Pyrrolo-quinoline quinone repeat [IPR002372]", "RNA helicase p68 repeat [IPR012587]", "RNA polymerase II, heptapeptide repeat, eukaryotic [IPR000684]", "Regulator of chromosome condensation, RCC1 [IPR000408]", "Ribonuclease inhibitor, leucine rich repeat cap [IPR041302]", "SAMP [IPR009224]", "Sel1-like repeat [IPR006597]", "Spectrin repeat [IPR002017]", "Spectrin/alpha-actinin [IPR018159]", "Tetratricopeptide repeat 1 [IPR001440]", "Tetratricopeptide repeat 2 [IPR013105]", "Tetratricopeptide repeat [IPR019734]", "Vesicle tethering protein p115, armadillo tether-repeat [IPR041209]", "WD40 repeat [IPR001680]", "Wolframin, Sel1-like repeat [IPR045458]", "Zinc finger, C2H2C-type [IPR002515]"], "available_proteins": ["AAAS", "ACTN1", "ACTN2", "ACTN4", "AIP", "ANAPC5", "ANAPC7", "ANK3", "ANKFY1", "ANKHD1", "ANKRD50", "ANP32A", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA6", "ANXA7", "AP1B1", "AP2B1", "APC", "ARMC1", "ARMC6", "ARMC8", "ARMCX3", "ARPC1A", "ASPH", "BIRC6", "BOP1", "BRAT1", "BUB3", "CAST", "CDC16", "CDC23", "CDC27", "CDC40", "CHAF1B", "CKAP5", "CLASP1", "CLPB", "CLTC", "CNN2", "CNN3", "COA7", "COLEC12", "COPA", "COPB2", "CORO1B", "CORO1C", "CRNKL1", "CSTF1", "CSTF3", "CTNNB1", "CTNND1", "CTR9", "CTTN", "DCAF13", "DCAF7", "DCTN6", "DDX5", "DNAAF5", "DNAJC3", "DNAJC7", "DOHH", "DSP", "DST", "DTL", "DYNC1I2", "EDC4", "EIF2B5", "EIF3I", "ELP2", "EMC1", "EMC2", "EML4", "EPPK1", "FIS1", "FKBP4", "FKBP5", "FKBP8", "FLII", "FLNA", "FLNB", "FLNC", "FNTB", "GCN1", "GEMIN5", "GLG1", "GLS", "GMPPA", "GMPPB", "GRWD1", "GTF2I", "GTF3C2", "GTF3C3", "HCFC1", "HECTD1", "HTT", "HUWE1", "IFIT5", "IGF2R", "ILK", "IPO4", "IPO5", "JUP", "KAT7", "KDELC2", "KDM2A", "KIAA1468", "KLC1", "KLC2", "KLC4", "KPNA1", "KPNA2", "KPNA3", "KPNA6", "KPNB1", "LARP1", "LASP1", "LDLR", "LLGL1", "LRBA", "LRPPRC", "LRRC40", "LRRC47", "LRRC57", "LRRC59", "MACF1", "MAP1B", "MAP4", "MAU2", "MIOS", "MKI67", "MPDU1", "MRPS27", "MTCH1", "MTCH2", "MTPN", "NAA15", "NASP", "NEK9", "NFKB1", "NHLRC2", "NISCH", "NLE1", "NOL10", "NOP2", "NOP9", "NUP214", "NUP37", "NXF1", "OGT", "P4HA1", "P4HA2", "PAFAH1B1", "PAK1IP1", "PDCD11", "PEX5", "PLAA", "PLEC", "PLRG1", "POLR2A", "PPID", "PPP1R12A", "PPP1R7", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP5C", "PREB", "PRKCSH", "PRMT9", "PRPF19", "PRPF39", "PRPF4", "PRPF6", "PSMD1", "PSMD10", "PSMD2", "PTCD1", "PTCD3", "PUM1", "PUM3", "PWP1", "PWP2", "RABEPK", "RACK1", "RAE1", "RAI14", "RANBP2", "RANGAP1", "RAP1GDS1", "RBBP5", "RCC1", "RCC2", "RNH1", "RPAP3", "RSU1", "SART3", "SCML2", "SCRIB", "SEC31A", "SEH1L", "SEL1L", "SGTA", "SHCBP1", "SHOC2", "SKP2", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A17", "SLC25A20", "SLC25A22", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A33", "SLC25A4", "SLC25A5", "SLC25A6", "SLIT2", "SMU1", "SNRNP40", "SNRPA1", "SPTAN1", "SPTBN1", "SPTBN2", "SRP72", "STIP1", "STRAP", "STRN", "STUB1", "SUGT1", "SYNE2", "TAGLN2", "TBL3", "TEX10", "THOC3", "THOC6", "TMTC3", "TOMM34", "TOMM70", "TTC1", "TTC19", "TTC26", "TTC37", "TTC4", "UNC45A", "USO1", "UTP15", "UTP18", "UTP4", "UTP6", "UTRN", "VPS18", "WDHD1", "WDR1", "WDR18", "WDR3", "WDR36", "WDR41", "WDR43", "WDR46", "WDR5", "WDR6", "WDR61", "WDR75", "WDR77", "WDR82", "WDR91", "WFS1", "WIPI2", "XAB2", "XPO1", "YTHDC2"], "leading_proteins": ["COA7", "GMPPB", "IPO4", "IPO5", "KLC2", "LDLR", "MTCH1", "SLC25A10", "SLC25A11", "SLC25A20", "SLC25A26", "SLC25A32"]} \ No newline at end of file diff --git a/msigdb_gobp/advanced/idx2term.json b/msigdb_gobp/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..4aaef5755c9bf94b4790c0f6fb403d973fcbe71b --- /dev/null +++ b/msigdb_gobp/advanced/idx2term.json @@ -0,0 +1 @@ +{"0": "Transmembrane transport", "1": "Mitochondrion organization", "2": "Mitochondrial transport", "3": "Anion transmembrane transport", "4": "Protein targeting", "5": "Ion transport", "6": "Anion transport", "7": "Mitochondrial transmembrane transport", "8": "Ion transmembrane transport", "9": "Organic acid transmembrane transport"} \ No newline at end of file diff --git a/msigdb_gobp/advanced/plot_0.png b/msigdb_gobp/advanced/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..ee8f4d09a8468fabdacb5b5476144dbf473ac962 --- /dev/null +++ b/msigdb_gobp/advanced/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:04d1c22da52ef604f5f8535d3b1f7dccea32eb38f3a91b1c002627ce5b29cd57 +size 221303 diff --git a/msigdb_gobp/advanced/plot_1.png b/msigdb_gobp/advanced/plot_1.png new file mode 100644 index 0000000000000000000000000000000000000000..9b29f6f57317c3acacc4af4bd6f598cff6c96f14 --- /dev/null +++ b/msigdb_gobp/advanced/plot_1.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid 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0000000000000000000000000000000000000000..532c623c447a9facf39ae87db5db588c4333348c --- /dev/null +++ b/msigdb_gobp/df_merge.tsv @@ -0,0 +1,121 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Transmembrane transport 63 182 4.744495563807213 2.090265597498586e-06 67.45631067961165 211.1359223300971 1.8122664376950308 0.3598356673827246 27.267027885156203 22.354947126810902 2.251277763144546 0.4188333713481413 1.89939537493522e-06 0.0008488822631774 1.1951250479775994e-05 0.0002006312644223 1.349098363447715e-08 +Mitochondrion organization 55 173 4.153157910968197 3.2791828341371954e-05 56.45873786407767 188.26941747572815 1.5905300936136977 0.4100157441778524 20.15716756472138 18.40319032732565 2.034523716094369 0.4327537677377048 0.0003660956955867 3.3144350008494626e-05 1.7739032619313823e-05 6.480870627166138e-06 4.7918940185135776e-12 +Mitochondrial transport 24 77 3.752500251246501 0.0001750796564872 26.76456310679612 83.42233009708738 1.9353944346565397 0.260698067067068 11.29934298946582 6.8259418360610375 1.9296757414965091 0.3685496297416806 1.24878804079225e-05 0.0001470258320256 6.692618059919773e-07 1.4469389918200683e-05 1.6316411213335398e-07 +Anion transmembrane transport 20 32 3.7175974150492954 0.0002011264417021 18.02912621359223 42.29854368932039 1.9137296804814252 0.1915609440243116 8.771596162415214 5.032004157423188 1.8922368499585025 0.2935375719655638 0.0002013653623679 0.0164824785433421 0.0001035971196841 0.0015592799821653 0.0003355986872213 +Protein targeting 30 95 3.625946603882296 0.0002879048461812 30.48543689320388 111.54126213592232 1.595466660966077 0.3336055854889273 10.683999539888966 11.70327920021055 1.673091584234216 0.3988264387816677 0.0006809879278309 2.271471423927721e-05 0.0001555388564876 0.000395332975748 1.6128237319503094e-06 +Ion transport 56 176 3.5308612705574385 0.0004142089338941 59.95631067961165 203.33495145631068 1.28794420214731 0.4483240343684334 22.7179419701651 20.293344878478432 1.852388371824549 0.4292871393353351 0.0005028992718413 0.186058060279213 0.0080127130369523 0.010688591819999 6.832017422743537e-05 +Anion transport 29 57 3.467829507756051 0.0005246800538747 26.953883495145632 69.53155339805825 1.854216838065017 0.2425457725148559 12.138973160217668 8.434296289414672 2.014686633079497 0.3448588040224388 0.0002943074680202 0.0710204091336867 0.0032691237730569 0.0034307421343376 0.0007408220711745 +Mitochondrial transmembrane transport 16 47 3.4515037740014765 0.0005574719602432 19.070388349514563 50.63834951456311 1.9310146760091371 0.188342667216329 9.760351579527285 3.939196260509299 1.9786128158557912 0.3017981993827387 0.0001531170074909 2.947739650573756e-06 1.7468478452227828e-05 0.0010205325993841 1.0245964570541212e-07 +Ion transmembrane transport 39 130 3.423428191766702 0.0006183658703866 47.09466019417476 154.11893203883494 1.555073205784263 0.3634279635891347 19.61122797656 15.97124025754773 1.9676287128633565 0.411597796705808 8.733424372759536e-05 0.067145446295508 0.000453379601163 0.0036340316587734 0.0002209212991476 +Organic acid transmembrane transport 17 26 3.343686313082029 0.0008267315979648 12.37621359223301 29.983009708737864 1.9038035525846064 0.1759244630123113 6.520447095353999 3.550222565141749 1.416714921004232 0.2641413901650407 9.966043049788446e-05 0.0564048148733258 0.0001210763991392 0.0006818386753638 0.0004595134276763 +Organic anion transport 20 38 3.259724604848688 0.0011152044122217 18.575242718446603 46.57281553398058 1.6158560948583975 0.2692356013040078 9.46386426798458 5.9518324529926545 1.7470285445738305 0.3371920110610632 0.0162750789224794 0.5027324490187645 0.0513626688490587 0.060695411188978 0.0484861136064748 +Organophosphate ester transport 8 23 3.256887582293364 0.0011264103406014 10.29126213592233 27.364077669902912 1.4948680330369015 0.1889391065154625 4.84293313185659 4.31957284765524 1.6451867819665518 0.2532208690981375 0.014545472613961 0.0063852408669871 0.0009958002736197 0.0121231126733016 0.0048410909429686 +Mitochondrial respiratory chain complex assembly 17 36 3.2180940440619805 0.0012904549916745 14.427184466019416 38.300970873786405 1.6683402305651691 0.229838901803248 5.648441561419256 5.588363345618 1.6629328950455762 0.3088219725228932 0.0062911328710141 0.0707254675278004 0.0018751862862679 0.0015917790382586 7.001018800285736e-06 +Steroid biosynthetic process 15 43 3.1935253872176417 0.0014054697886478 11.728155339805824 44.80825242718446 0.9874364787035632 0.3935759881445143 5.016369659264937 4.35272817633461 1.2862817592315925 0.3680333006848349 0.0003818801352558 0.0112094197529472 0.0024826734601412 3.597736784406734e-06 1.6262461377262097e-05 +Lipid metabolic process 70 233 3.15465004072044 0.0016069072843134 70.49514563106796 273.7014563106796 0.4234492243219149 0.5257500979287635 24.98470358696109 28.74867152381156 1.6795947056521872 0.4126649977131845 5.249857319234652e-09 0.0009844784673425 1.5132643490472813e-05 4.026871127363452e-09 2.9757660150500383e-09 +Sterol biosynthetic process 9 21 3.136506157997096 0.001709738462913 7.281553398058253 24.52912621359223 1.190088798384403 0.3136799329736269 3.292879861326439 2.61838648411319 1.1232845583768152 0.3105481837594456 2.038189458991049e-05 0.0014578554854327 0.0010831329822185 1.3667024405395029e-07 1.1641632653198346e-05 +Protein targeting to mitochondrion 15 42 3.116838706009739 0.0018280155658301 14.980582524271844 46.067961165048544 1.7767024064550243 0.249920045184344 6.494927942714517 4.708517660750424 1.5433015545903224 0.3384144763122346 0.0053486193257113 0.0008162643340865 0.0016161749700128 0.0012809712291409 4.455669256984436e-06 +Secondary alcohol metabolic process 14 41 3.054031691373858 0.0022578822767622 12.097087378640778 42.24514563106796 1.5200936296432006 0.2566232504859334 4.463475425703621 3.883072640851752 1.3223501002339118 0.3210874999447533 4.6468369730860673e-07 5.716735156291592e-05 0.0001926556516818 2.114379600046874e-09 3.8139219686128064e-06 +Sterol metabolic process 14 37 3.0310449977491705 0.0024370892520562 11.932038834951456 38.44660194174757 1.1656335789111734 0.2523239777622673 4.346099994655023 4.0619669904912925 1.6676089351046874 0.3062687621764124 3.65401767651598e-07 5.111567422339664e-05 0.0001694771292921 1.508380486564755e-09 2.772918242599647e-06 +Autophagosome maturation 6 19 3.0259859111214733 0.0024782385008177 4.742718446601942 17.16747572815534 0.0817445188148652 0.5991875967567871 2.8484061951846895 3.5558799160779064 0.838769675601762 0.2978968014658341 0.0657963288940516 0.0248381956323572 0.0876106046642714 0.1257511849434855 0.0112872973833843 +Protein transmembrane transport 12 24 2.9976893716581468 0.0027203479033004 8.992718446601941 25.191747572815533 1.6893060623430327 0.189108476986505 4.473486660459625 2.7693940759543416 1.4682653164365471 0.2783169275392022 0.0003828960250255 0.0020640692536444 0.0017009652209114 0.0016834035897202 6.742975984061605e-06 +Organic hydroxy compound biosynthetic process 16 50 2.9848581312992337 0.0028370987290264 12.42233009708738 52.37135922330097 0.7934054609743442 0.424605725297311 4.713262264354627 5.1877801804871915 1.1130427360157376 0.3580104692277669 0.0027063984756084 0.0248573684171094 0.0088599528646003 1.6564931621798416e-05 0.0002027795715202 +Establishment of protein localization to membrane 21 76 2.9596932914896947 0.0030794545434691 23.133495145631063 87.3616504854369 1.231448880072231 0.4195243824117992 8.397245527204214 9.510228790351464 1.3947369206386535 0.4065372973031916 0.0012695647831194 0.0163421355973242 0.0036470065281125 0.0040246499403502 0.0003861115405286 +Organic acid transport 19 40 2.9551695953091746 0.0031249721659794 16.199029126213592 46.1626213592233 1.6912598339530378 0.23494744574913 7.685833584742487 5.405881453891157 1.4084922190667013 0.315570201131532 0.0035661306981377 0.1403881914917208 0.0021256224119551 0.0182037584987757 0.0161311976150157 +Carboxylic acid transport 15 28 2.9208480966132546 0.0034907998504636 12.351941747572816 33.69417475728155 1.517249458545343 0.2522623764771551 6.23371050940395 4.11174791553619 1.419876490432768 0.3135855212793009 0.0123373855755018 0.3985608327989486 0.0820650305700749 0.0420396019683425 0.0700280573838956 +Steroid metabolic process 20 65 2.864328752562813 0.0041789404589991 17.82766990291262 66.9247572815534 0.9974586731388552 0.3270410156332073 6.090491666967852 5.93996409793671 1.7133199907504504 0.3720334828404655 2.7171860402293355e-05 0.0008713177508291 0.0007869081300806 2.1343652066055405e-07 1.816095540107139e-06 +Regulation of ph 6 18 2.8566814428863694 0.0042809524770739 6.890776699029126 20.859223300970875 1.2151699598837196 0.2373503364294603 2.930458126920059 2.7746402510870145 1.4154672965603718 0.2873526492076106 0.0146896731279065 0.0257535715284909 0.0139156518076104 0.0015231541907095 0.0034128621981353 +Regulation of cellular ph 6 18 2.8566814428863694 0.0042809524770739 6.885922330097087 20.844660194174757 1.215766922704761 0.2375185297794358 2.9319293283093293 2.765976649626597 1.4143296516981956 0.2875299337708636 0.0119899180814745 0.0230489069918226 0.0118453859760714 0.0011113418092766 0.0023236798464153 +Protein insertion into membrane 7 25 2.833503956109665 0.0046040738082018 9.861650485436892 27.67718446601942 1.4180388387951812 0.2751856944202687 4.426616888970974 3.3195747527036987 1.508549988584809 0.3318307488597651 0.0003095649899405 0.0248381956323572 0.0132042256106822 0.001374788533299 0.0007039256534767 +Sphingolipid metabolic process 11 24 2.804568630820307 0.0050383959919215 12.631067961165048 29.174757281553397 1.3566630100256978 0.1614907042591146 4.986857078326301 3.461093559903884 2.232073980338918 0.2503191978902473 0.0073491437061969 0.0748187401998431 0.0632302441478985 0.0019595403906339 0.0019650917814895 +Intracellular protein transmembrane transport 10 21 2.795487765735395 0.0051821463160577 7.233009708737864 21.9004854368932 1.450039081018812 0.2247265328975946 3.8281123729210935 2.4627910122818513 1.3220665029303609 0.2876555154826584 0.0012945129175601 0.0196403757049561 0.0093807730237194 0.0044406378118471 7.41330487327156e-06 +Alcohol biosynthetic process 9 34 2.7882892495420646 0.0052987210776525 9.344660194174756 36.09466019417476 1.0726679306851277 0.3539682718575088 3.792896481514287 3.1078151772256564 1.1587776417647702 0.3419459456532639 0.0010979226078437 0.0085976741283889 0.0104695800354931 4.9861626098174725e-05 0.0011005267490926 +Protein localization to endoplasmic reticulum 9 31 2.7795174912103477 0.0054439721617509 9.50242718446602 34.50485436893204 0.9935384348474128 0.428255638055916 4.399083524593319 2.6617527855555916 1.1934894982037212 0.3717243536861919 0.0199872505549988 0.0305319028295214 0.1057169178564165 0.0120464435451714 0.0003775126449021 +Sphingolipid biosynthetic process 7 13 2.7699686078918666 0.0056061695597984 6.543689320388349 16.33252427184466 1.3108583596388097 0.2293036031089034 3.2058099533310203 2.4273143169149307 1.5209865792019848 0.2861850290041513 0.0926279935222335 0.0325345581006573 0.1119611835326611 0.0138556470380734 0.0074744155515412 +Lipid biosynthetic process 46 119 2.730991701544795 0.0063144061579911 38.012135922330096 141.7257281553398 0.5620793375816577 0.4367444072022249 15.729119254593195 17.314902336322657 1.553306672697969 0.3832082090559359 3.053772652997664e-05 0.0039268429870404 0.0002249954417179 4.207171139260067e-06 9.023609274065702e-06 +Amyloid precursor protein catabolic process 7 16 2.707602327323108 0.0067771174856987 4.62621359223301 16.47087378640777 1.203006467000838 0.2754962460876 2.1329801006381106 2.1803683249886516 0.947433834000198 0.2709877848980267 0.0082408695261902 0.0188245552589776 0.0008428863370275 0.0213813720021448 0.0190396454378568 +Amyloid precursor protein metabolic process 8 18 2.706363761500556 0.0068024487618802 5.91747572815534 20.04368932038835 1.2306110398413417 0.2828388345239639 2.574706211328507 3.0661056512526157 1.0127867956133585 0.2841981221806073 0.0177456933272394 0.0285808600856777 0.0019520468500316 0.0438041643494559 0.0501645149458417 +Protein localization to mitochondrion 17 54 2.688110783624644 0.0071857552198641 18.37621359223301 58.6747572815534 1.743973973786015 0.2835887708870952 7.329731795051445 5.553888141183353 1.6030721833013164 0.3628376459321563 0.0035574182184986 0.001748605497394 0.0006199102456503 0.0012066818666679 9.65604113060143e-07 +Nadh dehydrogenase complex assembly 13 26 2.673235113042572 0.0075123578602704 9.266990291262136 26.96359223300971 1.1245271541492263 0.3013677937017552 4.122702675359976 4.029157649894909 1.4460543016521823 0.3224564676521605 0.0199872505549988 0.0305319028295214 0.0022276957658844 0.0024554723849656 1.4960350244519804e-05 +Cellular lipid metabolic process 48 167 2.645353071092297 0.0081605718542394 55.06310679611651 205.83495145631068 0.2402431693065998 0.4937242414097398 20.280338607556292 23.717838556123585 1.6370289909336062 0.4061780961812439 3.090167083277552e-06 0.0222458971274424 0.00168505750022 6.076403141299192e-06 1.1505736339239414e-06 +Negative regulation of mrna metabolic process 11 43 2.6257745446988365 0.0086452058575108 15.78640776699029 45.30339805825243 0.4317654752348391 0.5186468695555119 6.004287279655988 2.910090931551649 1.3207774317424965 0.3775544483756486 0.0422731404414429 1.0 0.5058832188962971 0.0017342876907798 3.781741218684139e-05 +Alcohol metabolic process 16 77 2.621513185515957 0.008754037593061 19.300970873786408 81.99029126213593 1.0392616248309592 0.3936245775900834 6.9548962308345 7.403089286448431 1.208378917036781 0.3759976884392474 0.0001148804452191 0.0031617577196828 0.0159805457687977 1.2407801327036288e-05 0.0013047046067613 +Monovalent inorganic cation homeostasis 6 22 2.6001856393480223 0.0093173341972143 9.014563106796116 27.87378640776699 1.1567920478867002 0.2845186374336156 4.051822262152646 3.607380814764068 1.4117439861533438 0.3149022278800241 0.0441107506526137 0.0479057539651017 0.0338721796728873 0.0083652800039346 0.0251503768819699 +Regulation of alternative mrna splicing via spliceosome 16 30 2.599492271512604 0.0093361780756748 10.609223300970871 30.575242718446603 0.1468114472042654 0.5502297177540902 5.108075880658377 2.6128265930148187 1.194088433027589 0.3536418549118582 1.0 1.0 1.0 0.0304079267330467 1.7824094846844216e-05 +Membrane lipid biosynthetic process 8 16 2.5975736501277296 0.0093884984014553 8.866504854368932 23.050970873786408 1.3229385051208649 0.2431293012321725 4.229937732502716 3.4850337476777224 1.635527795490498 0.2996124846932806 0.0626321140931459 0.0589240460435226 0.1891654013018039 0.0143895951598155 0.0063151145893543 +Membrane organization 52 197 2.585876177027689 0.0097131817355315 62.02427184466019 223.60922330097088 0.9560408776070136 0.5603311757674675 21.467957454898308 21.375973545731355 1.611091026762519 0.4273954777865132 0.0036144890289719 0.0125700639544009 0.0133359771981713 0.0010391563622735 1.531808060477643e-07 +Cellular monovalent inorganic cation homeostasis 6 20 2.5807236829608704 0.0098593461069762 8.191747572815533 25.12378640776699 1.1978511848260835 0.2636491484517694 3.558748260132903 2.9783551257949803 1.4212259473978417 0.3021468238591936 0.0249744489977978 0.0345877004093447 0.0212914346042941 0.0034676048515423 0.0091218528537202 +Lipoprotein metabolic process 4 15 2.578562772774691 0.0099212272161661 5.504854368932039 19.114077669902912 1.0723975558987071 0.2794846862458811 2.648039342123219 3.7213756556771336 1.2556798055308762 0.2951644225033464 0.2023862587700646 0.0627750690965546 0.049541392930243 0.150785190751036 0.2334873523449409 +Protein targeting to membrane 9 28 2.572139342440396 0.0101072202777161 9.03640776699029 34.86407766990291 0.8678999397376299 0.4369909067843477 3.776027437978551 4.807050937156168 0.9685770296783628 0.3476738150633759 0.0252429009029914 0.0094231818265578 0.0117389654214918 0.0697145733861968 0.0328355011999187 +Macroautophagy 18 95 2.5531396783916342 0.0106756674171279 25.570388349514563 102.68203883495146 0.4734815024857951 0.6429834425349866 8.949285204664525 14.162660044372751 0.8554944786686205 0.3590213706304501 0.0233454679601816 0.0085678735159534 0.11517267631025 0.0576461709628531 0.0592751309922312 +Membrane lipid metabolic process 16 29 2.55243364564509 0.0106973283543569 15.813106796116504 37.71116504854369 1.423850539998867 0.1808469841706369 6.252884620395072 4.742042041181393 2.289538519382486 0.2724480316274368 0.0063280314993918 0.1131277718078383 0.1111181143510491 0.0025115558955804 0.0020598266302504 +Calcium ion import 7 13 2.5115773067617635 0.0120192957135081 4.516990291262136 12.686893203883496 1.0417029373125424 0.2391249176108038 2.3196506830054986 1.9148178088324157 1.3383409214307818 0.27915846054651 0.0005195453252607 0.0135379522122687 0.0498890213657128 0.0018532910789756 0.0003323148542865 +Carbohydrate derivative transport 4 14 2.501368240933538 0.0123714467326554 7.924757281553398 17.024271844660195 1.3665639952580566 0.1869571280171947 4.210097511648942 2.624454303682939 1.5541767319140831 0.2467993156006303 0.0096316444062617 0.1991580424676108 0.0733374275738533 0.0247625444605767 0.0232948805615619 +Regulation of macroautophagy 7 49 2.49250626197103 0.0126845093843332 12.53883495145631 54.54368932038835 0.6601926076755246 0.5184966676512008 5.17189441564166 7.149617002477752 0.982640144191414 0.3711017134042489 0.0113024841218839 0.0038246242160168 0.0412611149036703 0.0161335998015439 0.1185309874607654 +Cellular ion homeostasis 21 75 2.473102354582737 0.013394577414113 24.48543689320388 87.34708737864078 0.921352068115914 0.4223079442129951 9.212290310790763 8.933596252465952 1.5207794649628892 0.4002972861975121 0.0114009584938122 0.1430583240174933 0.04953941476756 0.0155414152544489 0.0141335756318235 +Negative regulation of mrna catabolic process 7 23 2.469553108888971 0.01352819358971 9.169902912621358 24.631067961165048 0.5652120707700043 0.4958815262040553 4.097153521759381 1.8459627491120816 1.1372403168685192 0.3560626632344691 0.0089185628538315 1.0 0.3559802976275766 0.0230341265569123 0.0013172325096431 +Alternative mrna splicing via spliceosome 17 40 2.469342674753177 0.0135361525225188 14.009708737864075 40.728155339805824 0.0708159133159534 0.5694011596603432 6.451830696216548 3.032011011191426 1.225863726972057 0.3649890000258197 1.0 1.0 1.0 0.0191561107000251 1.7968915269104815e-06 +Glycerolipid biosynthetic process 13 31 2.464949984577417 0.0137032378033583 13.466019417475728 44.71844660194175 0.9430872689732808 0.3767257192898063 6.88753698417372 8.249645447783736 1.3199493331746477 0.3584243730449019 0.1136094596716592 0.2159364989363957 0.0082676305628072 0.2752497837530063 0.1731508608294167 +Inner mitochondrial membrane organization 12 19 2.4315314869564904 0.0150351414351386 9.985436893203884 20.800970873786408 1.138268089020681 0.2873707765098114 4.6289277788641146 2.4012939531921327 1.609232985153232 0.3229583948801056 0.0294754528646744 0.1635258499471353 0.0498890213657128 0.0596874537258691 5.28545782152457e-05 +Inorganic anion transport 7 17 2.4262268342172857 0.0152567310286768 9.900485436893204 25.351941747572816 1.3590123122148194 0.2025490755989976 4.608697956226863 4.352203003870329 1.5972877171217004 0.2769639658120273 0.0015718770752017 0.0432831882721129 0.0044625009891105 0.0063798653120075 0.0060441570275233 +Dicarboxylic acid transport 3 13 2.426104061663896 0.0152618934346473 5.718446601941747 16.097087378640776 1.1205667041867788 0.2998586575349944 3.584398436287638 2.226340822602054 1.0973546365412417 0.2986830136605488 0.0407839133045401 0.1835089509173778 0.0625314301217693 0.0808776862517318 0.1466332856037892 +Retrograde vesicle mediated transport golgi to endoplasmic reticulum 9 24 2.410124290283614 0.0159470867758033 7.771844660194175 26.825242718446603 1.1714448828781496 0.3436005361805324 3.811248488859092 3.450558374586287 1.1733172803389544 0.345676809182098 0.0103807974776341 1.0 0.3684815592825167 0.0265672828357611 0.0017644163862936 +Vacuolar acidification 4 8 2.3856999144526108 0.0170466545006984 3.4757281553398056 8.922330097087379 1.27407749822917 0.1611429668415415 1.4148632661931722 1.303016071016461 1.4195929612668792 0.2212670077717619 0.0039833056844136 0.0032958763634803 0.0006517968090871 0.0007869115437374 0.0013613651941044 +Organic hydroxy compound metabolic process 20 105 2.384132936816755 0.0171194169429278 24.233009708737864 110.8883495145631 0.5334558429683288 0.4627633417898757 8.017219191403747 10.01417249072314 1.2419084217888356 0.3713800795527268 6.97419866707352e-05 0.011836138245353 0.0066922838582481 6.185909305730052e-06 0.0003549686915583 +Regulation of amyloid precursor protein catabolic process 6 14 2.370693750335624 0.0177547355620846 3.8859223300970873 14.189320388349516 0.723751929535891 0.4024575578925681 1.8731873759514015 2.0164571748807374 0.9921534445034136 0.3036488689822377 0.0200979612678383 0.1430638950507344 0.0035907130786718 0.0415700360883472 0.0182596420242621 +Nitrogen compound transport 117 498 2.3702132175821133 0.0177778297094253 134.15533980582524 569.4538834951456 0.9072063241864304 0.6401677607980054 37.1767641393764 58.81145048559368 1.470232145086419 0.4303798393104362 0.0019945498179602 0.0016317658290086 0.0030691616261273 0.0004338711936744 3.2837906992459215e-10 +Ph reduction 6 12 2.362194446581217 0.0181671105851146 4.422330097087379 12.509708737864075 1.1966830084586066 0.1930048880851129 1.91475781321527 1.7851607614701208 1.4167744165903868 0.2497649393583847 0.0139964215949567 0.0078974776787256 0.0024390672757694 0.0004989114687539 0.0003032663260766 +Mitochondrial membrane organization 22 45 2.3603716569766875 0.0182566343224599 16.983009708737864 46.91019417475728 1.283632855732258 0.3380738792929293 7.413069190635445 4.027718639381892 1.6948461264793506 0.367302285357348 0.0081223820382775 0.0108990791164893 0.0023726768380501 0.0288939483426972 5.729130584608394e-05 +Peptide catabolic process 3 10 2.356500297013237 0.0184480528938646 3.871359223300971 10.351941747572816 1.5413280472635258 0.1625248535751528 1.454973091229298 0.9501768442987896 1.1353491763523988 0.2229381591694359 0.0003353441275824 0.0036723611473879 0.0007685743700876 0.0009779431698101 0.0017743753624758 +Lipid localization 17 66 2.3536887458380944 0.0185881683363542 20.1504854368932 74.27912621359224 1.3966421040883936 0.3001252105784707 7.306180038477171 9.39465098860316 1.572418240819249 0.3627304234720817 0.0007230932851093 0.0212658195237354 0.0013528882734038 0.0003082164034328 0.0056297151391449 +Tetrapyrrole metabolic process 10 20 2.334928350894234 0.0195471640106568 5.652912621359223 19.283980582524272 1.0342508202848784 0.290677507336007 2.6828141040028877 2.549402305664568 1.2308389507353266 0.2976223887279709 0.0458361846224961 1.0 0.0678620701894922 0.0901467992310857 0.0002221540307242 +Protein processing 12 42 2.330192602704363 0.0197959737770287 12.08252427184466 45.980582524271846 0.9011703887478908 0.3916089016010577 4.43430858840224 4.931040148104543 1.176660792763282 0.3507158233798557 0.0417326172674888 0.143685486645328 0.1526361156980193 0.0196856428380044 0.0180042278108211 +Phospholipid transport 4 11 2.3023996480518725 0.0213126448087075 4.038834951456311 13.844660194174756 0.8595089147672731 0.22382450694892 1.931709490395295 2.5542930986961077 1.4491821424024287 0.2459407475876757 0.0657963288940516 0.0248381956323572 0.0132042256106822 0.0345596402774107 0.1013718771427775 +Protein transmembrane import into intracellular organelle 6 13 2.2779223229185126 0.0227312060176647 4.951456310679611 13.45631067961165 1.503963012554726 0.1758225015375162 2.735521961789203 1.4944992929031071 1.2360761671845495 0.245991671368161 0.0168922283757233 0.0090330503435184 0.03403446937649 0.0352396407582777 0.0004790727366591 +Neutral lipid biosynthetic process 2 6 2.27447983596461 0.0229371521159509 2.1067961165048543 6.288834951456311 1.1186547336258812 0.1821371148552785 1.2515048910859687 1.3298556757746482 1.2887117600293918 0.213034599641239 0.0126637743692212 0.1221118561195742 0.0021930786590517 0.0267619345648551 0.1423023069394473 +Er nucleus signaling pathway 4 13 2.245356857008716 0.0247452327052815 4.563106796116505 13.361650485436892 0.3617919622488442 0.4304556920046536 2.3428051517114805 1.3174649068389608 1.1974910326877934 0.3346175168774911 0.1395968818221952 1.0 1.0 0.2166326226637888 0.0291816562890673 +Cell recognition 4 21 2.241256580645782 0.0250094597128338 5.29126213592233 22.859223300970875 0.9056944851933356 0.3618031966115522 2.859598274322472 2.538937048941188 0.9847101891513528 0.3060121099700091 0.0249744489977978 0.003086924646434 0.0212914346042941 0.0600215848699845 0.1753897866922502 +Vitamin transport 5 6 2.2208556632455703 0.0263607390266344 3.587378640776699 7.597087378640777 1.658661901456128 0.1256251915839625 1.8073839707699664 1.6422194495621811 1.0713624000848283 0.1994200282768667 0.0702930382809113 0.0058373227860703 0.0224191931510111 0.0195244436529747 0.0008256536450065 +Cytochrome complex assembly 9 11 2.194058312030256 0.0282312177320196 5.339805825242719 11.616504854368932 1.5489281771301031 0.1834582376033618 2.45860248431673 2.439266047793512 1.3189185418401956 0.2620853228235733 0.0236152804635877 1.0 0.0428134756181982 0.0484311287755044 0.0054583584483833 +Regulation of rna splicing 28 83 2.189421825638044 0.0285661947428288 27.91990291262136 86.5121359223301 0.1323494025528259 0.5572910110956871 9.72639747067558 5.208502039558804 1.4178017247437722 0.381677869420044 0.2287210963736818 1.0 1.0 9.636084073851644e-05 2.5129394182310242e-08 +Triglyceride metabolic process 3 10 2.170411540329166 0.0299756833320745 3.4805825242718447 10.771844660194176 0.9779567044833 0.270555786798488 1.9834538010888536 2.3392770219831345 1.099054194056709 0.249087443977639 0.0627348303608325 0.2145132052152406 0.0125141686162342 0.0324447271269302 0.2257163036668415 +Establishment of protein localization to endoplasmic reticulum 5 20 2.166965876684398 0.0302374561255327 5.657766990291262 22.070388349514563 0.461449325411609 0.540521677773824 3.0958573736115995 1.7687681096977308 0.870924743015325 0.3289535305239591 0.1272018826348283 0.151306852499084 0.2827159209662828 0.0484311287755044 0.0054583584483833 +Protein exit from endoplasmic reticulum 9 19 2.16525246068386 0.0303683568165158 7.002427184466019 21.233009708737864 0.6943602976218084 0.4745028866201709 3.210645812910548 2.182026685495945 1.0430444956616387 0.3507892727806736 0.0432728676833208 1.0 0.3432341150980792 0.0854582473740603 0.000965206072546 +Post translational protein modification 3 12 2.1567017064022145 0.0310289139546533 3.1941747572815533 11.516990291262136 0.7357713395172158 0.4534173687037079 1.6073753099185084 1.8147728922350523 0.7925975172795923 0.2972350127351547 0.0022950349488183 0.0096266028600564 0.0361556764775263 0.0063239101987386 0.0160305095638712 +Glycerophospholipid catabolic process 1 8 2.141870068182305 0.0322039390738881 2.216019417475728 7.563106796116505 0.8419758607208171 0.2558936783676348 1.405411068501889 1.391164232085279 1.2384126210044872 0.2497846504551273 0.0335851418894926 0.0742352733278267 0.0102498345034834 0.0561137872346343 0.1818418904091173 +Ion homeostasis 23 91 2.1382660791998886 0.0324951539691849 28.021844660194176 105.69174757281552 0.8349951537384392 0.4299135801564597 10.40966729997928 11.411952082971936 1.4722934854811005 0.3963893325418664 0.0185049301500345 0.2134389652995229 0.0424184398029792 0.0312453685102857 0.0344466089696522 +Cellular response to oxygen levels 5 31 2.133893075603627 0.032851534433266 8.393203883495145 36.271844660194176 0.9126927578207408 0.4163034805851183 3.607671495386698 4.048118764224637 0.9088125816374436 0.3418533733797396 0.0474331518074178 0.0149620345130709 0.0207919883966976 0.0471384538848185 0.2738776042777909 +Cation transport 33 131 2.1273587412441524 0.033390287496233 40.9247572815534 152.4733009708738 1.0106305648473772 0.4693050539746304 15.98502541638414 15.374508146736815 1.5607432077940149 0.4143686874753333 0.0381458057090768 0.4300237614022896 0.1094648642009153 0.1503333207766263 0.0280951671792052 +Intracellular protein transport 61 280 2.11842945901656 0.0341387131783692 72.23543689320388 320.84466019417476 0.4871189760263694 0.7214714639205947 20.45645165050656 29.914524602040487 1.0524664106682724 0.3751399671828122 0.003318695958085 0.0048398801149193 0.0062726320088765 0.0045163940634382 6.158598096716307e-07 +Localization within membrane 34 157 2.112360340357683 0.0346555539629735 43.83252427184466 179.48543689320388 0.7329824809593914 0.5973922945503244 12.803162929787796 21.32668417309247 1.133148805830878 0.4087008058998355 0.0149777894571055 0.2001597763973769 0.0960156324984252 0.0250391297678622 0.0115685813746833 +Isoprenoid metabolic process 3 15 2.104884660661758 0.0353013492566913 6.351941747572815 23.436893203883496 0.371913197601784 0.4325927382253215 2.8701546111232905 3.133501725907374 1.111400072689174 0.3110459828013394 0.0177456933272394 0.2333020504203794 0.416129272954638 0.0438041643494559 0.2796617582086531 +Vacuole organization 12 45 2.098404586860324 0.0358694204446583 14.220873786407768 51.74514563106796 0.8524122478550634 0.3147425083910056 5.370022076358251 7.439112114793103 1.7567175511320523 0.3563110134355993 0.1534868070067726 0.1706177828799348 0.1908142682494453 0.0826500662202803 0.0393722192481365 +Sulfur compound transport 3 6 2.0958049650937927 0.0360994957390889 3.504854368932039 9.429611650485436 1.339223354728307 0.2167503093092372 2.046184165461596 2.1092484385198076 1.0728301411615704 0.2604171804663498 0.0029012821517771 0.1471951297158956 0.0039222152641545 0.007920049564759 0.0747991773170861 +Regulation of protein secretion 7 31 2.095654103905444 0.0361128859999493 9.725728155339803 40.37135922330097 0.4397575592309385 0.6317801864713505 4.052449601261029 5.3326667855507255 0.7141892385666174 0.3295535821820476 0.1906692493702993 0.0215493976510864 0.1194557751624266 0.1822608250623231 0.1509071180896329 +Chemical homeostasis 40 153 2.0906579460560533 0.0365587373308089 43.762135922330096 177.7597087378641 0.7082111793088889 0.511106347874914 13.668464281922288 17.87763227716401 1.3204137511810292 0.4179418895476048 0.0029099206876813 0.1283171756643038 0.0076249678312492 0.0021704282741048 0.0031693595062689 +Calcium ion regulated exocytosis 3 9 2.076755550142108 0.0378241266619712 2.5825242718446604 8.966019417475728 0.2490819455283515 0.6155759649447953 1.894162067704679 1.2709642695136016 0.7341501796400864 0.2903992185898027 0.1150909213426581 1.0 0.2685353106225043 0.0415700360883472 0.0682397501835214 +Protein import into mitochondrial matrix 4 9 2.069905152458683 0.0384612273506699 3.3276699029126213 9.03883495145631 1.4677455160780188 0.1396272549365287 1.9612536628062327 0.7162785445212654 1.2893924319512868 0.2212161399323651 0.0297379856574316 0.0022827689145391 0.0090253131212995 0.0498779046475234 0.0005388274165263 +Terpenoid metabolic process 3 14 2.061872492639778 0.0392198770235274 4.992718446601942 17.42233009708738 0.6301104025923489 0.3704291423404849 2.365292196147205 2.02323551503238 1.1104102314092092 0.2862846297230793 0.0064128954450323 0.1795501084992132 0.3302382631712943 0.016869226769582 0.1376237189726102 +Nucleotide transport 4 12 2.061748111369783 0.0392317234871546 6.189320388349515 13.405339805825244 1.3859091987706234 0.2148450774807873 3.399469193898354 2.266957807297256 1.34942986946681 0.2785977875693559 0.0808586699002079 0.1178616319260966 0.0260710687649276 0.1300982938321277 0.0075753503172145 +Regulation of peptidyl tyrosine phosphorylation 3 21 2.061413187626263 0.0392636377860304 6.378640776699029 27.87135922330097 0.1802199323220069 0.6349333342581757 3.0857219100090787 4.315860914587658 0.7372095149693096 0.2961615496176262 0.3850230688469808 0.4463627535095094 0.6980596213140103 0.3425620879071548 0.8522677710622795 +Ceramide transport 3 5 2.054293135240907 0.0399473287612797 1.779126213592233 5.310679611650485 0.994079753441996 0.2057455404068654 1.027416031856974 0.785538294365343 1.3065287972688011 0.2361222749942 0.001492984644032 1.0 0.1191939669275513 0.0002022933287296 0.0028040242445346 +Amide transport 9 31 2.0508793975549606 0.0402786929645988 9.512135922330096 37.99757281553398 0.8625203235532012 0.4243895840783888 3.9342099663331425 4.541875701235624 0.963016155404646 0.3369249994514658 0.1054940829902849 0.1403881914917208 0.148051344240397 0.1154859850799389 0.070832822352764 +Triglyceride biosynthetic process 1 5 2.047256174742889 0.0406329384694226 1.4757281553398058 5.274271844660194 0.8957176915704722 0.2655240444557116 1.2274740041869927 1.2502497629633054 1.1422343750332298 0.2371147384530898 0.0651952457446114 0.1049896535105009 0.0206800818926893 0.1060727287920157 0.3097803043008575 +Vitamin transmembrane transport 4 5 2.0446773468492023 0.0408866783898105 2.9344660194174756 6.094660194174757 1.6910321805591797 0.1136175735100163 1.344920850275403 0.8913122381585616 1.0580472895861666 0.1862049292817703 0.0297379856574316 0.0022827689145391 0.0090253131212995 0.0051503840765812 0.0005388274165263 +Negative regulation of rna catabolic process 11 30 2.044212439617339 0.0409325648046183 11.186893203883496 32.42718446601942 0.419853700893663 0.5432159718224696 4.924332595678975 2.3133296381008863 1.0980554146273172 0.3596399931743501 0.0211705192410354 1.0 0.4330643878145832 0.0515621560092188 0.0067400711985061 +Regulation of lysosomal lumen ph 3 5 2.0419988823511632 0.0411516421948847 2.3567961165048543 5.58252427184466 1.1719038900849827 0.159040563248536 1.2351555175791742 1.4280428037740598 1.4707016211600112 0.2132438131163355 0.0297379856574316 1.0 0.1362380906066266 0.0051503840765812 0.0049531384619904 +Cation transmembrane transport 25 99 2.035695766499479 0.0417809144724898 33.43446601941748 118.4004854368932 1.1701058025505957 0.4085228823574113 14.425169362008605 12.553856783980793 1.6663185381795875 0.4066910074955585 0.0410963662623799 0.2674596328918705 0.0287463664251595 0.1968614013489574 0.0429237449491298 +Endoplasmic reticulum organization 13 38 2.032841738383909 0.0420685147765715 14.91747572815534 43.67718446601942 1.1418424810127707 0.3725584991544436 6.208589840117394 4.768440325801463 1.6823827875834556 0.3705219831566139 0.0025812076382897 0.0514861271532366 0.0375044006736284 0.0101205340460747 0.0010665292840946 +Regulation of pattern recognition receptor signaling pathway 3 17 2.028088130477025 0.0425512541124164 4.691747572815534 19.70873786407767 0.80673262224624 0.4173389113947272 2.517825740704142 3.173406084005513 0.919675411949683 0.3119180769844089 0.3128748600522999 0.0356328568827733 0.1215022402141297 0.1896820159952031 0.1837162306077457 +Mammary gland epithelium development 1 6 2.0275644590514803 0.0426047194409595 2.0533980582524274 7.504854368932039 0.4210175862420911 0.5353031153867802 1.3481605975882227 1.6670640805603438 0.7742467778819695 0.2853093207482 0.191328302708103 0.1913705796369965 0.0678620701894922 0.2887846572413305 0.6395483116168783 +Amyloid beta metabolic process 4 13 2.015133555208916 0.0438906572041108 3.6771844660194177 13.24514563106796 0.6724101183977472 0.416551332754989 1.8088680779022668 1.8049556184618043 1.0101286409291856 0.3102485572243311 0.171595728857192 0.1795501084992132 0.0599227725053796 0.2616785322574622 0.3228304985102302 +Protein insertion into er membrane 3 11 2.0089629297024194 0.0445410652371445 4.451456310679611 12.691747572815531 0.9645901040516046 0.3077872373135509 2.16101217194965 1.431147904526304 1.1733171268605926 0.305304417896891 0.0071262127795426 0.1006582454154426 0.1933613304033528 0.0153906222854723 0.020271757680103 +Rna stabilization 10 26 1.994896989561632 0.0460541159352803 9.359223300970871 27.37621359223301 0.4792302048577673 0.5262457931829767 4.411160534464403 1.6856669427134765 1.0994939820726763 0.3614208213771557 0.0597418076203794 1.0 0.3807425591652282 0.1151104414767163 0.0091015487948519 +Response to endoplasmic reticulum stress 26 74 1.9946561523194084 0.0460803947537271 20.766990291262136 81.87135922330097 0.3895578367391949 0.6272162805638101 7.658618957730667 6.11384352257493 0.925049322897134 0.3624458148773257 0.0301030280756399 0.6220632145766474 0.58191544243938 0.1129942712899203 0.0088518318158998 +Endoplasmic reticulum to golgi vesicle mediated transport 13 55 1.987903538587888 0.0468223593275685 17.32766990291262 65.39077669902913 0.808881464821498 0.4942452999677598 7.539018980743236 6.620812461410292 1.284359804176963 0.3933269611423161 0.0591175296030937 1.0 0.6764566213723024 0.0604720542414166 0.0013674597922856 +Glucose import 6 12 1.9819487887965253 0.0474849725981196 3.4563106796116503 11.364077669902912 0.3176045676169922 0.5089134846135845 1.8514056534885703 2.196305563870774 0.9183417404528994 0.3012736273802708 0.5640813813059148 1.0 0.3559802976275766 0.6691111110298131 0.0210947346086547 +Sensory perception of light stimulus 6 15 1.978125988903448 0.0479144953807246 5.009708737864078 15.96359223300971 0.918103407248628 0.3572194322029593 2.4583724414330383 3.147064390877318 0.9947617981182544 0.3055434177582076 0.3397106630031379 0.0399341953324298 0.1345193233748266 0.4776854569740084 0.0408844912350921 +Amino acid transport 8 16 1.9739258842167104 0.0483901710527903 7.771844660194175 19.75 0.8410032854505353 0.3449280742441291 4.117377746800764 3.003739578643708 1.287399790463736 0.3206698223659758 0.7204702238721555 1.0 0.4911024875738272 0.8169243745574313 0.6607071148756637 +Peroxisome organization 6 11 1.9713528345057016 0.0486835319423992 4.286407766990291 11.196601941747574 0.606295801393023 0.4614466229190617 2.3307796330420754 2.613015983661412 0.9820420209440194 0.3193147518558685 0.1091538613377818 1.0 1.0 0.1724444479617574 0.0160305095638712 +Regulation of autophagy 13 83 1.967507697711242 0.0491247093559032 20.118932038834952 94.3495145631068 0.711099590941891 0.531831837860264 6.9602150135047 11.998348379757145 0.9791686068293384 0.3767967479294735 0.011113499807536 0.041105407498933 0.1247903845539069 0.0151173218989615 0.175477658109293 diff --git a/msigdb_gobp/metrics.json b/msigdb_gobp/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..1e53ed94a0c0eace834c6907eb2e13f41ad1f569 --- /dev/null +++ b/msigdb_gobp/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2734, + "annotations_size": 6278, + "title": "Average number of proteins per term", + "value": 17.340554316661358 +} \ No newline at end of file diff --git a/msigdb_gobp/paths.json b/msigdb_gobp/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..63cf20860de80f6795b5b614fd476a0e37b27b4f --- /dev/null +++ b/msigdb_gobp/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/msigdb_gobp/fragment/C166/C166_val_log2fc"} \ No newline at end of file diff --git a/msigdb_gobp/result.tsv b/msigdb_gobp/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..f3f6f34c35cbdd31532fb727f49a6708602814b4 --- /dev/null +++ b/msigdb_gobp/result.tsv @@ -0,0 +1,1445 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Transmembrane transport 0.5180188688870818 4.744495563807213 2.090265597498586e-06 0.0130369738942259 0.0031167441690648 182 Q9HC07,Q99595,Q8IXU6,O60830,Q9Y277,P21796,P13073,Q9NS69,O75027,P23786,P45880,Q9H2D1,P41440,Q9BSK2,P51790,Q7KZN9,Q8IYU8,O43865,Q02978,P16615,Q96AQ8,Q13546,Q8WTV0,P11166,P28288,Q70HW3,Q15629,Q8NE01,P05067,Q8WWC4,O75323,P38435,Q99442,Q9UDW1,Q9UM00,O75298,O95202,Q6P4A7,O75964,Q96GC9,Q16625,P50570,Q9HD20,Q99797,P30825,P12236,Q9UBX3,P62942,Q8TB61,P50542,P27105,P04062,O43615,P31751,P08183,Q99523,O75844,Q13423,O14925,O96008,O43772,Q9UHG3,O75381 63 +Mitochondrion organization 0.4800605775962029 4.153157910968197 3.2791828341371954e-05 0.1860615041680144 0.0031167441690648 173 Q99595,Q9Y2R0,P27544,Q8TB36,Q9H845,O60830,O95168,P21796,P14406,Q9NS69,O75306,O75153,P45880,O96000,Q9Y6M9,Q9BSK2,Q13505,Q8IWA4,P55786,Q99536,Q9NX14,Q9H061,Q9NVA1,Q10713,O75431,Q8WWC4,O75323,Q15070,O95202,Q86Y39,Q99797,Q9P0J0,Q8N4H5,O95429,Q9H4A6,Q69YU5,Q5T9A4,Q96A26,P04062,O43615,O60313,O43676,Q9UDX5,Q9BWH2,Q9BUK6,Q9NVI7,Q5JRX3,O14925,O96008,Q7L592,Q6UXV4,Q9H3K2,P62072,Q8N2A8,P51572 55 +Mitochondrial transport 0.5436103036271002 3.752500251246501 0.0001750796564872 0.666877941482911 0.0041716977125909 77 Q99595,Q8TB36,O60830,Q9NS69,P23786,P45880,Q96EK5,P55786,Q10713,Q8WWC4,O75431,Q15070,O75964,Q99797,Q8N4H5,Q9UBX3,O95429,O43615,Q5JRX3,O14925,O96008,O43772,P62072,P51572 24 +Anion transmembrane transport 0.7082027101830458 3.7175974150492945 0.0002011264417021 0.7171387534297426 0.0043636293805978 32 Q9Y619,Q9Y277,P21796,P41440,P45880,Q9H2D1,P51790,Q02978,Q13546,Q9H9B4,P12236,P30825,Q9UBX3,Q8TB61,P08195,P08183,P53985,O60831,Q9UHG3,P53007 20 +Protein targeting 0.5051386184600757 3.625946603882296 0.0002879048461812 0.835973431868476 0.0055110996387184 95 Q99595,Q15005,Q8TB36,O60830,O60725,Q9NS69,P46379,P55786,Q14108,P43307,Q15629,Q10713,Q99442,Q99797,Q9P0J0,Q8N4H5,O95429,Q9Y5M8,P57105,P50542,O43615,P31751,Q99523,Q5JRX3,O14925,O96008,P51572,P62072,O43681,O75381 30 +Ion transport 0.4380605361331332 3.5308612705574385 0.0004142089338941 0.9257963835641646 0.0073579495157547 176 Q9HC07,Q9Y619,Q9Y277,P13073,P21796,P14373,O75027,P45880,Q9H2D1,P41440,P51790,Q7KZN9,Q8IYU8,O43865,Q02978,P16615,Q96AQ8,Q13546,P11166,P28288,Q70HW3,O76024,Q8NE01,P05067,O14936,Q8WWC4,O75323,Q9UDW1,Q9UM00,O95202,Q6P4A7,O75964,Q96GC9,P50570,Q9HD20,P12236,P30825,Q9UBX3,P62942,O15173,Q8TB61,P27105,P08195,P08183,Q13555,O75844,Q13423,Q9NZJ7,O96008,Q96S66,O43772,Q9UHG3,P07602,O43681,P51809,P13693 56 +Anion transport 0.5779501857792066 3.467829507756051 0.0005246800538747 0.9629247561316552 0.0086455154284136 57 Q9Y619,Q9C0H2,Q9Y277,P21796,P41440,Q9H2D1,P45880,P51790,O43865,Q02978,Q13546,P11166,P28288,Q9H9B4,Q7L0J3,P12236,P30825,Q9UBX3,Q8TB61,P08195,P08183,P53985,O60831,Q9NZJ7,Q96S66,Q9UHG3,P07602,O43681,P53007 29 +Mitochondrial transmembrane transport 0.5966583745155833 3.4515037740014765 0.0005574719602432 0.9698263077499376 0.0090979116986641 47 Q99595,O95202,Q6P4A7,O60830,O75964,P21796,O14925,O96008,O75027,O43772,P23786,Q9H2D1,Q9BSK2,Q8WWC4,O43615,Q96AQ8 16 +Ion transmembrane transport 0.4617573004302923 3.423428191766702 0.0006183658703866 0.979417245390735 0.0091214408491086 130 Q9HC07,Q9Y277,P13073,P21796,O75027,P45880,Q9H2D1,P41440,P51790,Q7KZN9,Q8IYU8,O43865,Q02978,P16615,Q96AQ8,Q13546,Q70HW3,P05067,Q8WWC4,O75323,Q9UDW1,Q9UM00,O95202,Q6P4A7,O75964,Q96GC9,P50570,Q9HD20,P12236,P30825,Q9UBX3,P62942,Q8TB61,P27105,P08183,O75844,Q13423,O43772,Q9UHG3 39 +Organic acid transmembrane transport 0.7083974023910822 3.343686313082029 0.0008267315979648 0.9944411699475112 0.0110824759835844 26 P53985,Q9Y619,P11166,O60831,P28288,P30825,O43772,P23786,Q9UBX3,P41440,Q9H2D1,P31751,P53007,Q9H9B4,P08195,Q02978,P08183 17 +Diacylglycerol biosynthetic process 0.964494875549049 3.26745513656324 0.001085190645065 0.9989044800127604 0.0136803752403986 2 Q9HCL2 1 +Diacylglycerol metabolic process 0.964494875549049 3.26745513656324 0.001085190645065 0.9989044800127604 0.0136803752403986 2 Q9HCL2 1 +Organic anion transport 0.6101460661542136 3.259724604848688 0.0011152044122217 0.9990928113345718 0.013974557484887 38 Q9Y619,Q15041,P41440,Q9H2D1,Q02978,P11166,P28288,Q9H9B4,P05141,Q7L0J3,P12236,P30825,Q9UBX3,Q8TB61,P08195,P53985,O60831,Q9NZJ7,P07602,P53007 20 +Organophosphate ester transport 0.7197975754964969 3.256887582293364 0.0011264103406014 0.9991545063294052 0.0140868607934182 23 Q8WTV0,Q14108,P22059,P41440,Q9H2D1,Q8TB61,Q9BSK2,P08183 8 +Glycolipid transport 0.9564421669106884 3.231978924777835 0.0012293612271316 0.9995573263483748 0.0150154275951998 2 Q9NZJ7 1 +Manganese ion transmembrane transport 0.9535139092240128 3.219041201932267 0.0012862000289131 0.999690316924103 0.0154688961331733 2 Q9HD20 1 +Manganese ion transport 0.9535139092240128 3.219041201932267 0.0012862000289131 0.999690316924103 0.0154688961331733 2 Q9HD20 1 +Mitochondrial respiratory chain complex assembly 0.6123781334680622 3.2180940440619805 0.0012904549916745 0.9996984902591938 0.0154903947184186 36 Q9Y2R0,Q15070,Q86Y39,Q9H845,Q96CU9,O95168,Q9NX14,Q9H061,O75306,Q9NVA1,Q9P0J0,Q7L592,O96000,Q9Y6M9,Q9BSK2,Q69YU5,O43676 17 +Steroid biosynthetic process 0.5816488441552775 3.1935253872176417 0.0014054697886478 0.9998536845657284 0.0160061242580358 43 Q15125,Q15800,Q16850,Q15392,P37268,Q9UBM7,Q14739,P16435,O75845,P22059,Q53GQ0,P48449,O14734,Q9BZF3,Q14534 15 +Transepithelial transport 0.944363103953149 3.1784818260768715 0.001480484990739 0.9999087010930652 0.0166866872026207 2 P08183 1 +Sulfate transport 0.9432650073206456 3.173601512007822 0.001505602424543 0.9999220384481728 0.0168233338567106 2 Q9UBX3 1 +Succinate transmembrane transport 0.9432650073206456 3.173601512007822 0.001505602424543 0.9999220384481728 0.0168233338567106 2 Q9UBX3 1 +Oxaloacetate transport 0.9432650073206456 3.173601512007822 0.001505602424543 0.9999220384481728 0.0168233338567106 2 Q9UBX3 1 +Calcium ion import into sarcoplasmic reticulum 0.9428989751098108 3.171974110496481 0.0015140650397942 0.9999260782467596 0.0168533693613975 2 O75844 1 +Lipid metabolic process 0.3942115803103548 3.1546500407204396 0.0016069072843134 0.9999587672616294 0.0175141734911803 233 P09960,Q8NEB9,P27544,Q16850,P37268,P50897,Q9BQE5,Q9H845,Q8TBX8,O15118,P23786,O75845,Q9BY49,P51648,Q9P035,Q8WTV0,Q96G23,P35790,Q15392,Q15067,O95470,Q06136,P21964,O14773,Q8N4Q0,P28288,P16435,Q8NBX0,Q10713,Q9BWD1,Q9NPH0,P05067,P07099,P38435,Q14534,Q8NHP8,Q15125,Q9HCL2,Q96N66,O15254,P48651,A1L0T0,Q15120,P22059,Q53GQ0,Q8NCG7,P40939,P04062,P16930,P31751,O14734,Q9BZF3,Q15800,Q8NCC3,Q9BT22,Q9UBM7,Q14739,O75844,Q9NZJ7,P49356,Q13011,P48449,Q9H6K4,O15269,P07602,O43681,O00767,Q16836,Q8N2A8,Q9H7Z7 70 +Phenol containing compound catabolic process 0.938872620790631 3.1540518629583483 0.0016102046760988 0.9999596133944816 0.0175196966317999 2 P16930 1 +Sterol biosynthetic process 0.7203858989148447 3.136506157997096 0.001709738462913 0.9999784023162968 0.0183169591641089 21 Q15125,Q15800,Q16850,Q15392,P37268,Q14739,P16435,P48449,Q14534 9 +Protein targeting to mitochondrion 0.577015538216726 3.116838706009739 0.0018280155658301 0.9999897351378206 0.0193856110173674 42 Q99595,Q8TB36,O60830,Q99797,Q5JRX3,O14925,O96008,Q9NS69,Q8N4H5,O95429,Q10713,P62072,O43615,P51572,P55786 15 +Microglia differentiation 0.9205710102489026 3.072102397651845 0.0021255679567004 0.9999984206826888 0.0215578604719962 2 P05067 1 +Secondary alcohol metabolic process 0.5737533976002307 3.054031691373858 0.0022578822767622 0.9999993130551236 0.0222459438327329 41 Q8WTV0,Q15125,Q15800,Q16850,P37268,Q15392,Q9BQE5,Q14739,O15118,P16435,P48449,P05067,P04062,Q14534 14 +Collateral sprouting in absence of injury 0.9125183016105428 3.0357905886985628 0.0023990592325799 0.9999997174440568 0.0233871022703993 2 P05067 1 +Sterol metabolic process 0.5858037611796532 3.0310449977491705 0.0024370892520562 0.9999997775849176 0.0237210020533471 37 Q8WTV0,Q15125,Q15800,Q16850,P37268,Q15392,Q9BQE5,Q14739,O15118,P16435,P48449,P05067,P04062,Q14534 14 +Autophagosome maturation 0.7216225244163936 3.0259859111214733 0.0024782385008177 0.9999998283300172 0.0239728525549056 19 Q8NEB9,Q9H9C1,P16615,P51809,Q9H267,Q9UEU0 6 +Regulation of mast cell activation 0.9088579795021978 3.019233445770426 0.0025341518090982 0.9999998792565272 0.0243263074273984 2 P09601 1 +Regulation of mast cell activation involved in immune response 0.9088579795021978 3.019233445770426 0.0025341518090982 0.9999998792565272 0.0243263074273984 2 P09601 1 +Regulation of retrograde protein transport er to cytosol 0.9081259150805312 3.0159181202399044 0.0025620243401449 0.9999998986846964 0.0245563187899696 2 P60604 1 +Protein transmembrane transport 0.6710327279752404 2.9976893716581468 0.0027203479033004 0.9999999626007756 0.0259549302992708 24 Q99595,O75298,O60830,O14925,O96008,Q9NS69,Q15629,O75381,P50542,O43615,P31751,Q99442 12 +Negative regulation of calcium ion import 0.9037335285505178 2.995998821116926 0.0027354749126951 0.9999999659978815 0.0260269003135752 2 P21796 1 +Organic hydroxy compound biosynthetic process 0.5386136850816263 2.9848581312992337 0.0028370987290264 0.9999999820669404 0.0265049193762325 50 Q15125,Q15800,Q16850,Q15392,P37268,Q9UBM7,Q14739,P16435,O75845,P22059,P48449,O15269,P04062,O14734,Q9BZF3,Q14534 16 +Folate transmembrane transport 0.9004392386530068 2.981028510732948 0.0028728204542676 0.9999999856787732 0.0266090647576284 2 Q9H2D1 1 +Folic acid transport 0.9004392386530068 2.981028510732948 0.0028728204542676 0.9999999856787732 0.0266090647576284 2 Q9H2D1 1 +Establishment of protein localization to membrane 0.473422638256378 2.9596932914896947 0.0030794545434691 0.9999999961013836 0.0279780255049193 76 O60725,Q9NS69,O15118,P46379,Q96A33,P43307,Q15629,Q8WWC4,Q99442,Q15070,Q8NBU5,Q9HD20,Q9P0J0,Q9H4A6,P50542,P31751,P61006,O15027,P62072,O43681,Q9BZG1 21 +Organic acid transport 0.566042045658886 2.9551695953091746 0.0031249721659794 0.9999999970730152 0.0283096324069533 40 Q9Y619,P23786,P41440,Q9H2D1,Q02978,P11166,P28288,Q9H9B4,Q7L0J3,Q6P4A7,P30825,Q9UBX3,P08195,P31751,P08183,P53985,O60831,O43772,P53007 19 +Positive regulation of protein neddylation 0.8920204978038082 2.9426504424856192 0.003254156293456 0.9999999987026033 0.0293107506604261 2 Q92564 1 +Cobalamin metabolic process 0.8916544655929771 2.940977885248619 0.0032717789127845 0.9999999988389058 0.029385161680202 2 Q96EY8 1 +Carboxylic acid transport 0.6323482220480467 2.9208480966132546 0.0034907998504636 0.9999999997077996 0.0311296043483106 28 P53985,Q9Y619,O60831,P28288,Q7L0J3,Q9NZJ7,P30825,Q9UBX3,P41440,Q9H2D1,P53007,Q9H9B4,P07602,P08195,Q02978 15 +Regulation of membrane lipid distribution 0.8806734992679404 2.8906474919802503 0.0038444908295565 0.9999999999685376 0.0325870405382617 2 P08183 1 +Lipid translocation 0.8806734992679404 2.8906474919802503 0.0038444908295565 0.9999999999685376 0.0325870405382617 2 P08183 1 +Glycerol 3 phosphate metabolic process 0.8799414348462719 2.887281524633998 0.0038858636777017 0.999999999975759 0.0327455733806864 2 Q9HCL2 1 +Steroid metabolic process 0.4956435714432904 2.864328752562813 0.0041789404589991 0.9999999999961784 0.0343198055907183 65 Q16850,P37268,Q9BQE5,O15118,Q8WTV0,O95470,Q15392,P16435,P05067,P38435,Q14534,Q15125,P22059,Q53GQ0,P04062,Q9BZF3,Q15800,Q9UBM7,Q14739,P48449 20 +T cell tolerance induction 0.8748169838945834 2.8636824721575733 0.0041874754830344 0.9999999999963788 0.0343198055907183 2 P01889 1 +Lymphocyte anergy 0.8748169838945834 2.8636824721575733 0.0041874754830344 0.9999999999963788 0.0343198055907183 2 P01889 1 +Regulation of ph 0.7023979177263086 2.8566814428863694 0.0042809524770739 0.9999999999979912 0.0349490502614697 18 Q93050,Q9HC07,Q9Y487,Q05086,Q8N511,O75503 6 +Regulation of cellular ph 0.7023979177263086 2.8566814428863694 0.0042809524770739 0.9999999999979912 0.0349490502614697 18 Q93050,Q9HC07,Q9Y487,Q05086,Q8N511,O75503 6 +Protein containing complex remodeling 0.872620790629582 2.853548582178264 0.0043233916801121 0.9999999999984628 0.0352496791788888 2 Q8WTV0 1 +Regulation of skeletal muscle adaptation 0.872254758418745 2.851858431136337 0.0043464453282224 0.9999999999986708 0.0353458338997159 2 P16615 1 +Skeletal muscle adaptation 0.872254758418745 2.851858431136337 0.0043464453282224 0.9999999999986708 0.0353458338997159 2 P16615 1 +Protein insertion into membrane 0.6405998304160582 2.8335039561096655 0.0046040738082018 0.9999999999997382 0.0371044613195007 25 Q96A33,Q15070,Q9NS69,P46379,Q15629,P62072,O43681 7 +Sphingolipid metabolic process 0.6426386083698933 2.804568630820307 0.0050383959919215 0.9999999999999832 0.0393910959368414 24 Q8NCC3,Q96G23,P27544,P50897,O95470,Q06136,Q9NZJ7,P22059,P07602,P04062,Q9P035 11 +Proton transporting two sector atpase complex assembly 0.9688840412765364 2.7972977441375164 0.005153202008632 0.9999999999999918 0.040238559962925 3 Q8N511 1 +Intracellular protein transmembrane transport 0.6668264970917088 2.795487765735395 0.0051821463160577 0.9999999999999932 0.040314144451314 21 Q99595,O75298,O60830,O14925,O96008,Q15629,O75381,O43615,P31751,Q99442 10 +Alcohol biosynthetic process 0.5700255248138053 2.7882892495420646 0.0052987210776525 0.9999999999999968 0.0408725593087328 34 Q15125,Q15800,Q16850,Q15392,P37268,Q14739,P16435,P48449,P04062 9 +Protein localization to endoplasmic reticulum 0.5908509031628839 2.7795174912103473 0.0054439721617509 0.9999999999999988 0.0417814880580349 31 Q9NQC3,P24390,O15027,P46379,Q15629,Q9Y5M8,O43681,P51572,Q99442 9 +Iron coordination entity transport 0.8550512445095204 2.77204278227002 0.005570571468298 0.9999999999999994 0.0423116565927144 2 O15173 1 +Heme transport 0.8550512445095204 2.77204278227002 0.005570571468298 0.9999999999999994 0.0423116565927144 2 O15173 1 +Regulation of sulfur metabolic process 0.8550512445095169 2.772042782270007 0.0055705714682983 0.9999999999999994 0.0423116565927144 2 Q15120 1 +Sphingolipid biosynthetic process 0.7820323960419596 2.7699686078918666 0.0056061695597984 0.9999999999999996 0.0423844976715825 13 Q96G23,P27544,O95470,Q06136,P22059,P04062,Q9P035 7 +Neurofilament cytoskeleton organization 0.8543191800878518 2.7686298627170363 0.0056292546747529 0.9999999999999996 0.0424765154424267 2 Q16352 1 +Chloride transmembrane transport 0.8521229868228464 2.7583829845462353 0.0058088097839963 1.0 0.0436216600764701 2 Q9UHG3 1 +Lipid biosynthetic process 0.4166032085637804 2.730991701544795 0.0063144061579911 1.0 0.04663746101161 119 Q8NEB9,Q9NZ01,Q16850,P37268,P27544,Q8TBX8,P11802,O75845,Q96BW9,Q9BY49,Q9P035,Q8WTV0,Q96G23,P35790,Q15392,O95470,P28288,Q06136,P16435,Q8NBX0,Q10713,Q9NPH0,Q14534,Q15125,Q9HCL2,Q96N66,P48651,P22059,Q53GQ0,Q86YN1,Q8NCG7,P04062,Q9NTJ5,O14734,Q92643,Q9BZF3,Q15800,Q8NCC3,O95864,Q9UBM7,Q14739,P48449,O15269,Q9BXW7,O00767,Q9H7Z7 46 +Intraciliary transport involved in cilium assembly 0.8437042459736488 2.7189902123919034 0.0065481545687253 1.0 0.0480810694531671 2 A0AVF1 1 +Positive regulation of protein exit from endoplasmic reticulum 0.8429721815519797 2.71555625995801 0.0066164533589432 1.0 0.048525810966642 2 P51572 1 +Walking behavior 0.9482622093343772 2.711537784456767 0.0066971907731814 1.0 0.0488894926442244 3 O75844 1 +Amyloid precursor protein catabolic process 0.7067946685875676 2.707602327323108 0.0067771174856987 1.0 0.0494154977644794 16 O75298,Q9NQC3,P49840,Q15392,O95197,P62942,Q96P70 7 +Amyloid precursor protein metabolic process 0.6779357169228127 2.706363761500556 0.0068024487618802 1.0 0.0495426604722558 18 O75298,Q9NQC3,P49840,Q15392,Q13526,O95197,P62942,Q96P70 8 +Peptidyl serine autophosphorylation 0.839677891654468 2.700086618900606 0.0069321425173369 1.0 0.0501569479976445 2 Q13546 1 +Response to sodium arsenite 0.8393118594436304 2.698366066091078 0.0069680770561793 1.0 0.0502077257723317 2 P07196 1 +Negative regulation of t cell apoptotic process 0.8389458272328043 2.696645172292312 0.0070041859869438 1.0 0.0502077257723317 2 Q9HCL2 1 +Regulation of t cell differentiation in thymus 0.8389458272328038 2.696645172292312 0.0070041859869438 1.0 0.0502077257723317 2 O96005 1 +Positive regulation of t cell receptor signaling pathway 0.8389458272327988 2.696645172292291 0.0070041859869443 1.0 0.0502077257723317 2 P23396 1 +Positive regulation of antigen receptor mediated signaling pathway 0.8389458272327988 2.696645172292291 0.0070041859869443 1.0 0.0502077257723317 2 P23396 1 +Phosphate ion transport 0.9431408173708244 2.69010634745347 0.007142925204385 1.0 0.0502164439340756 3 Q9UBX3 1 +Phosphate ion transmembrane transport 0.9431408173708244 2.69010634745347 0.007142925204385 1.0 0.0502164439340756 3 Q9UBX3 1 +Protein localization to mitochondrion 0.5039632715611042 2.688110783624644 0.0071857552198641 1.0 0.0503223017666823 54 Q99595,Q15070,Q8TB36,O60830,Q99797,Q5JRX3,O14925,O96008,Q9NS69,Q8N4H5,O95429,Q10713,P62072,Q8WWC4,O43615,P51572,P55786 17 +Nadh dehydrogenase complex assembly 0.6116404091760355 2.673235113042572 0.0075123578602704 1.0 0.0514512201418957 26 Q15070,Q86Y39,Q9H845,Q96CU9,O95168,Q9NX14,Q9H061,O75306,Q9P0J0,Q7L592,O96000,Q9Y6M9,O43676 13 +Fluid transport 0.8338213762811189 2.6725168214216524 0.0075284599885607 1.0 0.0514512201418957 2 O43865 1 +Cellular lipid metabolic process 0.3846960604392501 2.645353071092297 0.0081605718542394 1.0 0.0526209373455547 167 Q8NEB9,P27544,P50897,P37268,Q9H845,P23786,Q9BY49,P51648,Q9P035,Q8WTV0,Q96G23,P35790,Q15067,O95470,Q06136,Q8N4Q0,P16435,Q8NBX0,Q10713,Q9BWD1,Q9NPH0,P07099,Q8NHP8,Q9HCL2,Q96N66,O15254,P48651,A1L0T0,Q15120,P22059,Q53GQ0,Q8NCG7,P40939,P04062,P31751,O14734,Q15800,Q8NCC3,Q9BT22,O75844,Q9NZJ7,Q13011,P48449,O15269,P07602,O00767,Q16836,Q9H7Z7 48 +Protein import into peroxisome matrix 0.8275988286969325 2.6431280120532845 0.0082143972066848 1.0 0.0526209373455547 2 O75381 1 +Aromatic amino acid transport 0.8268667642752645 2.6396639970214424 0.0082988260271834 1.0 0.0526795043464689 2 P30825 1 +Phosphatidylinositol dephosphorylation 0.8265007320644241 2.6379314751944887 0.0083413435365693 1.0 0.0528959138611943 2 Q10713 1 +Negative regulation of mrna metabolic process 0.517849394363782 2.6257745446988365 0.0086452058575108 1.0 0.0540947694660576 43 Q99729,P35637,P22626,Q13242,O60506,P98175,Q14103,Q13151,P38159,Q92804,P61978 11 +Alcohol metabolic process 0.4437877215806017 2.621513185515957 0.008754037593061 1.0 0.0544137109002348 77 Q8WTV0,Q15125,Q15800,Q16850,Q15392,P37268,Q9BQE5,Q14739,O15118,P16435,P48449,Q9BY49,P05067,P04062,P51648,Q14534 16 +Monovalent inorganic cation homeostasis 0.6284585924486769 2.6001856393480223 0.0093173341972143 1.0 0.057403556516302 22 Q9HC07,Q93050,Q9Y487,Q05086,Q8N511,O75503 6 +Regulation of alternative mrna splicing via spliceosome 0.5750642903138048 2.599492271512604 0.0093361780756748 1.0 0.0574473615636812 30 Q92841,O75525,P17844,Q07666,P14866,P98175,P38159,Q06787,Q9Y5S9,Q15287,P09651,Q8IY67,P62995,Q9UHX1,Q9BWF3,P31483 16 +Membrane lipid biosynthetic process 0.6881693858872191 2.5975736501277296 0.0093884984014553 1.0 0.0574473615636812 16 Q96G23,P27544,O95470,Q06136,P22059,Q8NBX0,P04062,Q9P035 8 +Protein retention in er lumen 0.8169838945827308 2.5927653977312013 0.0095207691189889 1.0 0.0579939118652472 2 P24390 1 +Maintenance of protein localization in endoplasmic reticulum 0.8169838945827308 2.5927653977312013 0.0095207691189889 1.0 0.0579939118652472 2 P24390 1 +Prostate gland growth 0.9198095935554742 2.591796987435619 0.0095476094014705 1.0 0.0580812905256127 3 P07602,Q9NZJ7 2 +Positive regulation of triglyceride metabolic process 0.9188308754567648 2.5876487199251756 0.0096633471181941 1.0 0.0586149692831139 3 Q8WTV0 1 +Membrane organization 0.3760893767231653 2.585876177027689 0.0097131817355315 1.0 0.058759861817206 197 P50897,Q9NS69,O15118,P46379,P45880,P41440,P51790,Q13505,Q8IWA4,Q00765,P16615,Q86XL3,Q9NQC3,Q96A33,Q15392,Q9HCU5,Q9NR31,Q15629,O75431,Q8WWC4,Q13190,Q15070,O95202,O15400,Q96GC9,P50570,O95487,Q9P0J0,P22059,Q9H4A6,P57088,O43760,P31751,P08183,O60313,Q9ULX6,Q8N1F7,P61006,Q9P2W9,O75844,Q9UQB8,Q9NZJ7,O15027,Q9BZG1,Q6UXV4,Q9H3K2,P62072,O43681,P51809,Q9H267,P50402,Q9UEU0 52 +Cellular monovalent inorganic cation homeostasis 0.6424147067808392 2.5807236829608704 0.0098593461069762 1.0 0.0594591497210345 20 Q9HC07,Q93050,Q9Y487,Q05086,Q8N511,O75503 6 +Lipoprotein metabolic process 0.7047303261923961 2.578562772774691 0.0099212272161661 1.0 0.0597275145986317 15 Q9NUJ1,Q8NEB9,P04062,Q9BQE5 4 +Protein targeting to membrane 0.5851014228424595 2.572139342440396 0.0101072202777161 1.0 0.0607102549659901 28 O43681,P43307,O60725,P46379,Q15629,P50542,P27105,P31751,Q99442 9 +Ornithine transport 0.8125915080527177 2.5718411069399636 0.0101159307433971 1.0 0.0607102549659901 2 P30825 1 +Fatty acid elongation 0.8118594436310433 2.568348903221514 0.0102184248788663 1.0 0.0612130452190105 2 Q9P035 1 +Macroautophagy 0.4193945626948681 2.5531396783916342 0.0106756674171279 1.0 0.0629313052063188 95 Q93050,Q8NEB9,P27544,Q96GC9,P21796,Q8TBX8,Q9H9C1,P51809,O15118,Q9Y6I9,Q9Y679,O15269,P09601,Q9H267,P04062,Q9Y487,P16615,Q9UEU0 18 +Membrane lipid metabolic process 0.5758751704364553 2.55243364564509 0.0106973283543569 1.0 0.0629998380944214 29 Q8NCC3,Q9NZ01,P27544,P50897,Q96G23,O95470,Q06136,Q9NZJ7,P22059,Q8NBX0,O15269,P06865,P04062,P07602,Q92643,Q9P035 16 +Pyramidal neuron differentiation 0.907412578429749 2.539107449778039 0.0111135684942711 1.0 0.0652675238606494 3 O14949 1 +Lysosomal lumen acidification 0.905529110216038 2.531074757686681 0.0113713609406604 1.0 0.0663141836125073 3 Q8N511,O75503 2 +Leydig cell differentiation 0.8030746705710146 2.526334870594826 0.0115259558600409 1.0 0.0668761098792392 2 O95470 1 +Calcium ion import 0.7334790103359917 2.5115773067617635 0.0120192957135081 1.0 0.0691906382239886 13 Q8WWC4,P21796,O75844,P14373,O14936,P16615,Q96AQ8 7 +Spermidine metabolic process 0.7990483162518304 2.507011995037341 0.0121756579744873 1.0 0.0692128789949268 2 P49366 1 +Polyamine metabolic process 0.7990483162518304 2.507011995037341 0.0121756579744873 1.0 0.0692128789949268 2 P49366 1 +Carbohydrate derivative transport 0.7100892385737092 2.501368240933538 0.0123714467326554 1.0 0.0696190206273436 14 P07602,Q8WTV0,Q9NZJ7,Q8TB61 4 +Regulation of macroautophagy 0.4881895109768238 2.49250626197103 0.0126845093843332 1.0 0.0700605686812608 49 Q93050,Q8NEB9,P27544,P21796,O15118,P09601,Q9Y487 7 +Response to light intensity 0.7957540263543288 2.4911712769460026 0.0127322725218945 1.0 0.0700605686812608 2 P31751 1 +Muscle hypertrophy in response to stress 0.7950219619326584 2.4876473159221018 0.0128591184189583 1.0 0.0706295235644975 2 P16615 1 +Xenobiotic transport 0.8949102892713292 2.4856506276067174 0.0129314848982395 1.0 0.0708410664844224 3 P41440,P08183 2 +Chondroitin sulfate biosynthetic process 0.7942898975109882 2.484121972342631 0.0129871316053664 1.0 0.0708984454073831 2 Q96L58 1 +Chondroitin sulfate proteoglycan biosynthetic process 0.7942898975109882 2.484121972342631 0.0129871316053664 1.0 0.0708984454073831 2 Q96L58 1 +Chondroitin sulfate proteoglycan metabolic process 0.7942898975109882 2.484121972342631 0.0129871316053664 1.0 0.0708984454073831 2 Q96L58 1 +Regulation of steroid hormone biosynthetic process 0.7939238653001546 2.4823587820688706 0.0130515789181422 1.0 0.0711883687646368 2 P16435 1 +Cellular ion homeostasis 0.4330170402903762 2.473102354582737 0.013394577414113 1.0 0.0724299371281671 75 Q9HC07,P50897,O75027,P51790,Q9Y487,P16615,Q96AQ8,Q93050,Q96A33,O76024,P09601,P05067,Q8WWC4,Q8N511,O75503,Q9UM00,O95202,Q9HD20,P62942,Q05086,P51572 21 +Negative regulation of mrna catabolic process 0.6022603184230699 2.469553108888971 0.01352819358971 1.0 0.0727568198085387 23 Q99729,P35637,O60506,P98175,Q14103,Q13151,Q92804 7 +Alternative mrna splicing via spliceosome 0.510795130764962 2.469342674753177 0.0135361525225188 1.0 0.0727568198085387 40 P23246,O75525,P52272,Q13242,Q07955,P17844,Q07666,P14866,P98175,P38159,Q15287,P09651,Q8IY67,P62995,Q9UHX1,Q9BWF3,P31483 17 +Glycerolipid biosynthetic process 0.5509802030139197 2.464949984577417 0.0137032378033583 1.0 0.0735289973756271 31 Q8WTV0,Q8NEB9,P35790,Q9HCL2,Q96N66,Q8NCC3,Q8TBX8,Q9BXW7,P48651,Q10713,Q9NPH0,Q9NTJ5,Q92643 13 +Inner mitochondrial membrane organization 0.6272190696554986 2.4315314869564904 0.0150351414351386 1.0 0.0787244519848209 19 O95202,Q5XKP0,Q8WWC4,Q9NX63,Q9P0J0,Q6UXV4,Q9H3K2,P62072,Q13505,O60313,Q16891,O75431 12 +Gdp metabolic process 0.882094470889784 2.4305191287195687 0.0150772101609419 1.0 0.0788789378253281 3 O14936,Q14168 2 +Inorganic anion transport 0.6402234722348431 2.4262268342172857 0.0152567310286768 1.0 0.0795006927674726 17 P21796,Q9UBX3,P45880,Q9UHG3,O43681,Q02978,P08183 7 +Dicarboxylic acid transport 0.717743510644097 2.426104061663896 0.0152618934346473 1.0 0.0795006927674726 13 Q9H2D1,Q02978,Q9UBX3 3 +Mitochondrion endoplasmic reticulum membrane tethering 0.8809959721713658 2.4257778215294947 0.0152756188282086 1.0 0.0795006927674726 3 O43865,P16615 2 +Autophagosome membrane docking 0.8804767332143708 2.4235358322834135 0.0153702368640982 1.0 0.0797208531835646 3 P16615 1 +Retrograde vesicle mediated transport golgi to endoplasmic reticulum 0.58657119505892 2.410124290283614 0.0159470867758033 1.0 0.0816605308144319 24 Q9Y282,Q8TD16,Q9P2W9,P24390,P35606,Q9H4A6,Q6NUQ1,O15258,Q96RQ1 9 +Microglial cell activation 0.8752515001367859 2.400943196003592 0.0163528747706573 1.0 0.0832630558071265 3 P05067 1 +Positive regulation of striated muscle contraction 0.7763543191800861 2.3973191031802004 0.016515533674517 1.0 0.0840231121625755 2 P05023 1 +Vacuolar acidification 0.8698122321800386 2.3856999144526108 0.0170466545006984 1.0 0.0860280522149394 8 Q93050,Q8N511,Q9Y487,O75503 4 +Organic hydroxy compound metabolic process 0.394826518550945 2.384132936816755 0.0171194169429278 1.0 0.0861439106193146 105 Q16850,P37268,Q9BQE5,O15118,Q9BY49,P51648,Q8WTV0,Q15392,P21964,P16435,P05067,Q14534,Q15125,P22059,P04062,P16930,Q9BZF3,Q15800,Q14739,P48449 20 +Regulation of amyloid precursor protein catabolic process 0.6869894872127251 2.3706937503356236 0.0177547355620846 1.0 0.0888869456608989 14 O75298,Q9NQC3,P49840,O95197,P62942,Q96P70 6 +Nitrogen compound transport 0.3497596925488465 2.3702132175821133 0.0177778297094253 1.0 0.0889316453512128 498 Q99595,Q8NEB9,A6NIH7,Q16850,O60830,O60725,Q9H9C1,Q9NS69,P46379,Q9H2D1,P55786,Q14108,P43307,Q13432,P00367,P60604,Q9Y282,Q15070,Q9HD20,P30825,Q8N4H5,Q8TB61,P31751,P08183,Q9P2W9,Q9NZJ7,Q14168,O43772,Q9BTX1,P62072,P07602,O75381,Q32P28,P24390,O43865,Q96PC5,Q9BUN8,Q8TCT9,Q15629,Q8TEX9,Q13190,Q9ULJ7,P22626,P51991,P22059,O15173,O95429,Q9Y5M8,Q9ULX6,P61006,Q5JRX3,Q07666,A0AVF1,O43681,P51809,Q16836,P51572,Q9H267,Q9UEU0,P50897,Q9Y277,P41440,P35606,Q9BSK2,Q92945,Q96P70,Q13546,O43823,Q10713,Q8WWC4,Q99442,Q8TD16,Q6P4A7,Q96GC9,Q9H6U6,O95487,Q9H4A6,Q6NUQ1,P40939,O43615,Q13555,Q8N1F7,Q8NFH4,Q99523,O75312,O14925,O96008,O15126,O15027,Q9BZG1,P50402,Q15005,Q8TB36,Q9Y3E0,O75027,P67809,Q9Y679,P61960,Q9HCU5,O60488,Q15154,Q9NR31,Q969Q5,O15127,P09651,O75298,O15400,Q99797,P50570,P12236,Q9P0J0,P57105,P50542,P27105,P08195,Q5JVF3,O95071 117 +Ph reduction 0.7420807219924338 2.362194446581217 0.0181671105851146 1.0 0.0900182480294789 12 Q93050,P50897,Q9Y487,Q05086,Q8N511,O75503 6 +Negative regulation of peptide secretion 0.8660353354791133 2.360957642517425 0.0182278124363399 1.0 0.0901056743900333 3 Q16836 1 +Negative regulation of hormone secretion 0.8660353354791133 2.360957642517425 0.0182278124363399 1.0 0.0901056743900333 3 Q16836 1 +Mitochondrial membrane organization 0.4824589072953625 2.3603716569766875 0.0182566343224599 1.0 0.0901771441985865 45 Q9NS69,Q9NX63,P45880,Q13505,Q8IWA4,P49840,Q9Y276,Q8WWC4,P05141,O75431,Q15070,O95202,Q5XKP0,Q53H12,Q9P0J0,P50542,O60313,Q6UXV4,Q9H3K2,P52789,P62072,Q16891 22 +Peptide catabolic process 0.8061365476526845 2.356500297013237 0.0184480528938646 1.0 0.0908367655432801 10 P09960,P42892,P55786 3 +Lipid localization 0.4463829039979971 2.3536887458380944 0.0185881683363542 1.0 0.0909559788118721 66 Q8WTV0,P11166,P35790,Q14108,Q99720,Q9BQE5,Q9NZJ7,O15118,P23786,P22059,O43772,P07602,P04062,P31751,P08183,Q9BZF3,Q14534 17 +Epithelial cell differentiation involved in prostate gland development 0.8622514902247118 2.344490295899421 0.0190531063308425 1.0 0.0919786678593486 3 Q9NZJ7 1 +Negative regulation of response to food 0.7653733528550595 2.3437651315092825 0.0190901886302534 1.0 0.0919786678593486 2 P80303 1 +Regulation of response to food 0.7653733528550595 2.3437651315092825 0.0190901886302534 1.0 0.0919786678593486 2 P80303 1 +Regulation of appetite 0.7653733528550595 2.3437651315092825 0.0190901886302534 1.0 0.0919786678593486 2 P80303 1 +Phosphatidylcholine catabolic process 0.9572303088864058 2.335694911366962 0.0195071479000188 1.0 0.093485400394136 4 Q8WTV0 1 +Tetrapyrrole metabolic process 0.605314568748959 2.334928350894234 0.0195471640106568 1.0 0.0936057175125121 20 P36551,O00264,P53004,Q99707,O75027,P09601,P30043,Q7KZN9,P30519,Q96EY8 10 +Protein processing 0.4893646253400693 2.330192602704363 0.0197959737770287 1.0 0.0946527976939731 42 Q15005,Q8NEB9,Q15392,Q8TCT9,Q99797,O75844,Q5JRX3,Q92896,P42892,P67812,Q10713,O75503 12 +Embryonic digestive tract development 0.7606149341142046 2.3204620702750107 0.0203158944859751 1.0 0.0964774474908865 2 P00813 1 +Positive regulation of erad pathway 0.8547148460540879 2.3116030195309065 0.0207995700897654 1.0 0.0984763959453599 3 P46379 1 +Phospholipid transport 0.7662804098978668 2.3023996480518725 0.0213126448087075 1.0 0.1001502875067858 11 P22059,Q8WTV0,Q14108,P08183 4 +Protein transmembrane import into intracellular organelle 0.6908322015596025 2.2779223229185126 0.0227312060176647 1.0 0.1051632360935146 13 Q99595,O60830,O14925,O96008,O43615,O75381 6 +Neutral lipid biosynthetic process 0.899183770956526 2.27447983596461 0.0229371521159509 1.0 0.1058642362857236 6 Q8WTV0,Q9HCL2 2 +Pons development 0.8454811047457614 2.2711513607417304 0.0231378167014502 1.0 0.1060858383061056 3 O14949 1 +Positive regulation of activated t cell proliferation 0.8397055977506283 2.245761057374637 0.0247193169299348 1.0 0.1098286423822585 3 Q9HCL2 1 +Er nucleus signaling pathway 0.684979129533478 2.2453568570087157 0.0247452327052815 1.0 0.1098660331851183 13 O76024,Q96A33,P16615,Q9UM00 4 +Cell recognition 0.5841965044287372 2.241256580645782 0.0250094597128338 1.0 0.110804084740417 21 P05067,P45880,Q9NQC3,Q8WTV0 4 +Long chain fatty acid import across plasma membrane 0.8364499704153336 2.2314186755337135 0.0256534089261402 1.0 0.1130983857010591 3 P31751 1 +Vitamin transport 0.8863636363636365 2.2208556632455703 0.0263607390266344 1.0 0.1149254997286189 6 P11166,Q8WTV0,P41440,Q9H2D1,P04062 5 +Regulation of neuronal action potential 0.7364568081991317 2.2012608263227396 0.0277175644005056 1.0 0.1194309329487852 2 P04062 1 +Regulation of transmission of nerve impulse 0.7364568081991317 2.2012608263227396 0.0277175644005056 1.0 0.1194309329487852 2 P04062 1 +Regulation of long term synaptic depression 0.7364568081991288 2.201260826322727 0.0277175644005065 1.0 0.1194309329487852 2 Q9NUL3 1 +Cytochrome complex assembly 0.7448406730226163 2.194058312030256 0.0282312177320196 1.0 0.1210625580065705 11 Q9Y2R0,Q15070,O75880,Q9NVA1,O43819,Q9BSK2,Q7KZN9,P53701,Q69YU5 9 +Regulation of triglyceride metabolic process 0.9206675362322284 2.190858701298507 0.0284620191214233 1.0 0.1218857817491784 4 Q8WTV0,Q96N66 2 +Regulation of rna splicing 0.4039538325659749 2.189421825638044 0.0285661947428288 1.0 0.1220555115374747 83 P98175,P61978,Q15637,Q9UHX1,Q5BKZ1,P84103,P35637,P52597,P14866,P55795,P09651,P62995,Q96EP5,P22626,P38159,P31942,Q9BWF3,O75525,O75312,Q13242,Q07955,Q07666,P31943,Q15287,P98179,Q8IY67,Q13595,P31483 28 +Very long chain fatty acid catabolic process 0.8244687432890916 2.1784510647373003 0.0293724716701104 1.0 0.1239249846404258 3 Q15067 1 +G protein coupled purinergic receptor signaling pathway 0.7313323572474418 2.175785231481812 0.0295713235038441 1.0 0.1240967706932758 2 P00813 1 +Purinergic nucleotide receptor signaling pathway 0.7313323572474418 2.175785231481812 0.0295713235038441 1.0 0.1240967706932758 2 P00813 1 +Regulation of adenylate cyclase activating g protein coupled receptor signaling pathway 0.7313323572474391 2.175785231481797 0.0295713235038452 1.0 0.1240967706932758 2 P49840 1 +Organic cation transport 0.9167463904023424 2.175193351803083 0.0296156301743582 1.0 0.1241996835234607 4 Q70HW3 1 +Triglyceride metabolic process 0.7677073855275964 2.170411540329166 0.0299756833320745 1.0 0.1253746435434804 10 Q8WTV0,Q9HCL2,Q96N66 3 +Negative regulation of tumor necrosis factor superfamily cytokine production 0.8223805577321031 2.1691897311445896 0.0300682824351887 1.0 0.1256782138003429 3 P14373 1 +Establishment of protein localization to endoplasmic reticulum 0.5805505200812392 2.166965876684398 0.0302374561255327 1.0 0.1259659917425976 20 P46379,Q15629,Q9Y5M8,O43681,Q99442 5 +Protein exit from endoplasmic reticulum 0.5869983915236706 2.1652524606838597 0.0303683568165158 1.0 0.1264274165080148 19 Q9BUN8,Q8TCT9,Q9HCU5,O15260,O15027,Q9NR31,Q9Y679,P51572,P60604 9 +Membrane protein intracellular domain proteolysis 0.8203992893503407 2.160394469170546 0.0307421452517853 1.0 0.1277325465194665 3 Q8TCT9 1 +Post translational protein modification 0.7032631969962636 2.1567017064022145 0.0310289139546533 1.0 0.1287505101171934 12 O60725,Q9H9C1,P46977 3 +Ventricular cardiac muscle cell development 0.7258418740849206 2.1484167181200817 0.0316806658583166 1.0 0.1305226128295353 2 P02545 1 +Ventricular cardiac muscle cell differentiation 0.7258418740849206 2.1484167181200817 0.0316806658583166 1.0 0.1305226128295353 2 P02545 1 +Glycerophospholipid catabolic process 0.8154274294937172 2.1418700681823055 0.0322039390738881 1.0 0.1321755507024976 8 Q8WTV0 1 +Ion homeostasis 0.3927214446226502 2.1382660791998886 0.0324951539691849 1.0 0.1328854161348278 91 Q9HC07,P50897,O75027,P51790,Q8IYU8,Q9Y487,P16615,Q96AQ8,Q93050,Q96A33,O76024,P09601,P05067,Q8WWC4,Q8N511,O75503,Q9UM00,O95202,Q9HD20,P62942,P30519,Q05086,P51572 23 +Cellular response to oxygen levels 0.5104700470338313 2.133893075603627 0.032851534433266 1.0 0.1336492024350746 31 Q9Y487,O75306,P09601,Q8N511,P55786 5 +Bone growth 0.8143910335700524 2.1336743899949613 0.0328694438610632 1.0 0.1336492024350746 3 O75844 1 +Growth plate cartilage development 0.8143910335700524 2.1336743899949613 0.0328694438610632 1.0 0.1336492024350746 3 O75844 1 +Cation transport 0.3719341474061485 2.1273587412441524 0.033390287496233 1.0 0.1355037006472858 131 Q9HC07,P13073,P21796,P14373,O75027,P51790,Q7KZN9,Q8IYU8,O43865,P16615,Q96AQ8,Q70HW3,O76024,P05067,O14936,Q8WWC4,O75323,Q9UDW1,Q9UM00,O95202,O75964,Q96GC9,P50570,Q9HD20,P30825,P62942,O15173,P27105,Q13555,O75844,Q13423,O43772,P51809 33 +Response to thyroglobulin triiodothyronine 0.7207174231332447 2.1228048243932056 0.0337702104130355 1.0 0.1367802457890561 2 P11166 1 +Macropinocytosis 0.81098093589221 2.1184767927952692 0.0341347083088416 1.0 0.1376511505034053 3 Q9BZG1 1 +Intracellular protein transport 0.3342615207613427 2.1184294590165593 0.0341387131783692 1.0 0.1376511505034053 280 Q99595,Q15005,Q8TB36,O60830,O60725,Q9H9C1,Q9NS69,P46379,P35606,O43865,Q9Y679,Q96P70,P55786,Q9BUN8,P61960,Q14108,P43307,Q8TCT9,Q9HCU5,Q15154,Q9NR31,Q15629,Q969Q5,Q8TEX9,Q10713,Q8WWC4,Q13190,P60604,Q99442,Q9Y282,O75298,Q15070,O15400,Q99797,Q9H6U6,O95487,Q9P0J0,Q8N4H5,O95429,Q9Y5M8,P57105,P50542,O43615,P31751,Q8N1F7,Q99523,P61006,Q9P2W9,O75312,Q5JRX3,O14925,O96008,Q14168,O15027,P51572,P62072,O43681,O75381,Q9H267,P50402,Q9UEU0 61 +Localization within membrane 0.3593507376033377 2.112360340357683 0.0346555539629735 1.0 0.1391096980687648 157 O00264,O60725,Q9NS69,O15118,P46379,P41440,Q96A33,P43307,Q15629,Q9HD45,Q8WWC4,Q99442,Q9ULJ7,Q15070,O15400,Q8NBU5,P50570,Q9HD20,Q9P0J0,O95429,Q9H4A6,P57105,P50542,P31751,P61006,Q9NZJ7,Q14168,O15027,Q9BTX1,P62072,P07602,O43681,Q9BZG1,Q9UEU0 34 +Isoprenoid metabolic process 0.6246270658378142 2.104884660661758 0.0353013492566913 1.0 0.1412162023038054 15 P48449,Q9BY49,P37268 3 +Vacuole organization 0.4556834636113086 2.098404586860324 0.0358694204446583 1.0 0.1415120638829872 45 Q9HC07,Q8NEB9,P50897,Q14108,Q96GC9,Q8TBX8,Q9BZG1,P54802,O75503,P04062,Q8N511,P16615 12 +Sulfur compound transport 0.8567497670080703 2.0958049650937927 0.0360994957390889 1.0 0.1416979364423011 6 Q8TB61,Q9UBX3,Q70HW3 3 +Regulation of protein secretion 0.5058813396543188 2.095654103905444 0.0361128859999493 1.0 0.1416979364423011 31 Q32P28,Q8NEB9,Q16850,P00367,P22059,Q9H4A6,Q16836 7 +Chemical homeostasis 0.3602561503485192 2.0906579460560533 0.0365587373308089 1.0 0.1426350246304615 153 Q9HC07,P50897,O75027,O15118,P51790,Q8IYU8,Q9HCD5,Q9Y487,P16615,Q96AQ8,Q9P035,Q93050,Q8WTV0,Q9NQC3,Q96A33,Q15067,O76024,Q8NE01,P09601,P05067,Q8WWC4,Q8N511,P62995,O75503,Q9UM00,Q9HCL2,O95202,O15254,Q9HD20,Q15120,P62942,P22059,P30519,P04062,Q05086,P42785,Q9BWH2,Q5BJF2,P06737,P51572 40 +Rna import into mitochondrion 0.7133967789165425 2.0861034758860093 0.0369692509232173 1.0 0.1439782613498501 2 Q8TCS8 1 +Positive regulation of lipid catabolic process 0.8033987400760383 2.0846028001792547 0.0371053701083541 1.0 0.1444187932673572 3 P31751 1 +Regulation of cysteine type endopeptidase activity involved in execution phase of apoptosis 0.7119326500732158 2.0787473694786507 0.0376405766140841 1.0 0.1456471977734179 2 P23396 1 +Positive regulation of chemokine c c motif ligand 5 production 0.7115666178623732 2.076907521959809 0.0378100953818765 1.0 0.1457441979274035 2 O00571 1 +Chemokine c c motif ligand 5 production 0.7115666178623732 2.076907521959809 0.0378100953818765 1.0 0.1457441979274035 2 O00571 1 +Calcium ion regulated exocytosis 0.775070582668415 2.0767555501421073 0.0378241266619712 1.0 0.1457441979274035 9 Q68EM7,Q9BRK5,P16615 3 +Protein import into mitochondrial matrix 0.7736290989068791 2.069905152458683 0.0384612273506699 1.0 0.1472314544557962 9 Q99595,O14925,O43615,O60830 4 +Terpenoid metabolic process 0.6337524705309407 2.061872492639778 0.0392198770235274 1.0 0.1491803513339532 14 P48449,Q9BY49,P37268 3 +Nucleotide transport 0.6856224418746002 2.061748111369783 0.0392317234871546 1.0 0.1491803513339532 12 P41440,Q9H2D1,Q8TB61,Q9BSK2 4 +Regulation of peptidyl tyrosine phosphorylation 0.5584734957055104 2.061413187626263 0.0392636377860304 1.0 0.1492049851917498 21 P05067,Q13432,O95684 3 +Ceramide transport 0.8884091676790492 2.054293135240907 0.0399473287612797 1.0 0.1510438388829469 5 P07602,Q9NZJ7,P08183 3 +Amide transport 0.5005311125849362 2.0508793975549606 0.0402786929645988 1.0 0.1521197448597996 31 Q9NZJ7,P00367,P41440,Q9H2D1,P22059,P40939,Q16836,P07602,P08183 9 +Positive regulation of heart rate 0.7956792383742218 2.049998894397677 0.0403645387006692 1.0 0.1521973417194003 3 P00813,P16615 2 +Striated muscle adaptation 0.7953130721347492 2.0483545963637284 0.0405252669723985 1.0 0.1527116602957491 3 P16615,Q13555 2 +Triglyceride biosynthetic process 0.8866743103277124 2.047256174742889 0.0406329384694226 1.0 0.1530255475171177 5 Q8WTV0 1 +Vitamin transmembrane transport 0.8860388420667051 2.0446773468492023 0.0408866783898105 1.0 0.1538888290954619 5 Q8WTV0,Q9H2D1,P41440,P04062 4 +Negative regulation of rna catabolic process 0.5057057797718056 2.044212439617339 0.0409325648046183 1.0 0.1539692281865753 30 Q99729,P35637,O60506,O95453,P98175,Q14103,Q13151,P67809,Q92804,P07910,Q96HR8 11 +Regulation of lysosomal lumen ph 0.8853789933570007 2.0419988823511632 0.0411516421948847 1.0 0.154700604610471 5 Q9HC07,Q8N511,O75503 3 +Purine deoxyribonucleoside triphosphate metabolic process 0.793066469472407 2.0382603336658773 0.0415239045432169 1.0 0.1548942796924041 3 P55263 1 +Cation transmembrane transport 0.3766327167239134 2.035695766499479 0.0417809144724898 1.0 0.1554834505384063 99 Q9HC07,P13073,P21796,O75027,P51790,Q7KZN9,Q8IYU8,P16615,Q96AQ8,Q70HW3,P05067,Q8WWC4,O75323,Q9UM00,Q9UDW1,O95202,O75964,Q96GC9,P50570,Q9HD20,P30825,P62942,P27105,Q13423,O43772 25 +Regulation of sprouting angiogenesis 0.7920172059545595 2.0335425007866363 0.0419977442584678 1.0 0.1560129221625212 3 P14618 1 +Endoplasmic reticulum organization 0.4685363122251204 2.032841738383909 0.0420685147765715 1.0 0.1561834037654148 38 O00429,Q9NQC3,Q96A33,Q9P2W9,O43681,Q12981,O95197,O15027,P46379,Q15629,P50542,P57088,Q00765 13 +Protein import into peroxisome membrane 0.7908093634385331 2.028109000288965 0.042549124541606 1.0 0.1572317676973222 3 P50542 1 +Regulation of pattern recognition receptor signaling pathway 0.5783827724368081 2.0280881304770255 0.0425512541124164 1.0 0.1572317676973222 17 O43657,Q9NQC3,Q9NPR9 3 +Mammary gland epithelium development 0.8407498612067807 2.0275644590514803 0.0426047194409595 1.0 0.1572657667716851 6 Q9NQC3 1 +Tolerance induction 0.7893510173313183 2.021544841150081 0.0432233953879921 1.0 0.158780852104046 3 P01889 1 +Regulation of tolerance induction 0.7893510173313183 2.021544841150081 0.0432233953879921 1.0 0.158780852104046 3 P01889 1 +Phosphatidylglycerol biosynthetic process 0.7884634166161708 2.0175476514370287 0.0436383935112019 1.0 0.1597895391419755 3 Q9HCL2 1 +Amyloid beta metabolic process 0.6442010448054596 2.0151335552089154 0.0438906572041108 1.0 0.1603873957668266 13 O75298,Q9NQC3,O95197,P49840 4 +Cysteine metabolic process 0.6991215226939964 2.0141589429595315 0.0439928487254528 1.0 0.1606673090741087 2 P25325 1 +Protein insertion into er membrane 0.7087909227915328 2.0089629297024194 0.0445410652371445 1.0 0.161728633637243 11 P46379,Q96A33,Q15629 3 +Rna stabilization 0.5209295740024006 1.994896989561632 0.0460541159352803 1.0 0.1662860856267185 26 P35637,O60506,O95453,P98175,Q14103,Q13151,P67809,Q92804,P07910,Q96HR8 10 +Response to endoplasmic reticulum stress 0.3967403646964316 1.9946561523194084 0.0460803947537271 1.0 0.1662860856267185 74 Q9UBU6,P46379,P41440,O95881,Q7Z2K6,Q9Y679,Q96JB5,P16615,Q9BUN8,P61960,Q96A33,Q8TCT9,O14967,O76024,Q9UBV2,P60604,Q9UM00,O00571,P57088,O60313,Q13144,Q92905,O15027,Q9H3N1,P51572,Q8IXB1 26 +Photoreceptor cell maintenance 0.7828132434612505 1.9920673402702964 0.0463636698035296 1.0 0.1668985774234858 3 P11166 1 +Endoplasmic reticulum to golgi vesicle mediated transport 0.4343115752728069 1.987903538587888 0.0468223593275685 1.0 0.1680679084382361 55 Q96PC5,Q9Y282,Q9P2W9,P24390,Q9HCU5,O95487,O15027,P35606,P51572,Q6NUQ1,P51809,Q96RQ1,Q13190 13 +Glucose import 0.6709345588180554 1.9819487887965257 0.0474849725981196 1.0 0.1697160212955833 12 P11166,O75298,Q99523,Q16625,P52789,P31751 6 +Very low density lipoprotein particle assembly 0.6921669106881421 1.9789316862878477 0.0478236981520445 1.0 0.1706862859571014 2 P35610 1 +Regulation of phosphatidylcholine biosynthetic process 0.6921669106881402 1.9789316862878397 0.0478236981520454 1.0 0.1706862859571014 2 Q8NF37 1 +Sensory perception of light stimulus 0.603902823730394 1.978125988903448 0.0479144953807246 1.0 0.1708274486762624 15 P50897,Q13432,O76024,Q9H6K4,O43924,O60313 6 +Amino acid transport 0.5869731244445553 1.9739258842167104 0.0483901710527903 1.0 0.1720234959622976 16 Q9Y619,O60831,Q7L0J3,Q6P4A7,Q15041,P30825,Q9H9B4,P08195 8 +Peroxisome organization 0.7015509922562854 1.971352834505702 0.0486835319423992 1.0 0.1728705958904879 11 P28288,Q96HA9,O75381,P40855,P50542,O14734 6 +Regulation of autophagy 0.386844825049657 1.967507697711242 0.0491247093559032 1.0 0.1738713878195894 83 Q93050,Q8NEB9,P27544,P61006,P21796,O75844,Q9NZJ7,O15118,P09601,Q9NZ45,P07602,P04062,Q9Y487 13 +Process utilizing autophagic mechanism 0.3568970578960729 1.9591467897296044 0.050095598543183 1.0 0.1757460024744817 143 Q8NEB9,P27544,P21796,P14373,Q9H9C1,Q8TBX8,O15118,Q9Y679,Q9Y487,P16615,Q93050,P61960,P09601,Q9NZ45,Q86UE4,Q96GC9,Q9H6U6,P04062,P61006,Q9BWH2,O75844,Q9NZJ7,O15027,Q9Y6I9,O15269,P07602,P51809,Q9H267,Q9UEU0 29 +Regulation of toll like receptor signaling pathway 0.7754594583349244 1.9585603432685057 0.0501642976651883 1.0 0.1757460024744817 8 Q9NQC3,Q9NPR9 2 +Glycerophospholipid biosynthetic process 0.5158567479428364 1.9554687466103375 0.0505277687561389 1.0 0.1761317780405554 26 Q8NEB9,P35790,Q9HCL2,Q96N66,Q8TBX8,Q9BXW7,P48651,Q10713,Q9NPH0,Q9NTJ5,Q92643 11 +Erad pathway 0.4778023992402411 1.9552047386263585 0.0505589095018159 1.0 0.1761425271101002 33 Q9BUN8,Q96A33,Q8TCT9,Q9UBU6,P46379,P51572,P60604 7 +Cellular response to ether 0.7742655193284882 1.953404487974162 0.050771684859987 1.0 0.1766877148287133 3 Q9H4A6 1 +Signal peptide processing 0.8600732600732606 1.9459810792337675 0.0516570124492639 1.0 0.179470240263685 4 Q8TCT9,O75503,P67812 3 +Mitochondrial electron transport ubiquinol to cytochrome c 0.8583328240764794 1.9388611733919476 0.0525182448334753 1.0 0.1819589078722727 4 O14949 1 +Amyloid fibril formation 0.7203517357712635 1.935860083697136 0.0528848396923113 1.0 0.1829261837952236 10 P62942,P05067,Q13546 3 +Inorganic ion transmembrane transport 0.3751240450509437 1.9256337504898309 0.0541501213919501 1.0 0.1865831295821423 93 Q9HC07,P13073,P21796,O75027,P51790,Q7KZN9,Q8IYU8,Q02978,P16615,Q96AQ8,Q8WWC4,O75323,Q9UM00,Q9UDW1,O95202,O75964,Q96GC9,P50570,Q9HD20,Q9UBX3,P62942,P27105,Q13423,Q9UHG3 24 +Collateral sprouting 0.7655704378335892 1.9139345762355549 0.055628515754452 1.0 0.1896880068865672 3 P05067 1 +Histone h4 k12 acetylation 0.6786237188872646 1.910006503125568 0.0561323760126752 1.0 0.1907953744491475 2 O95251 1 +Inorganic anion transmembrane transport 0.8526320590161216 1.908193852605665 0.056366165876394 1.0 0.1912793456064876 5 Q02978,Q9UHG3,Q9UBX3 3 +Lytic vacuole organization 0.5242915131318335 1.905603916026812 0.0567016136825977 1.0 0.1921297862879858 23 Q9HC07,P50897,Q14108,Q9BZG1,P54802,P04062,Q8N511,O75503 8 +Phosphatidylethanolamine metabolic process 0.8500548164779034 1.9049333308502767 0.056788737923989 1.0 0.1921297862879858 4 Q8NCC3 1 +Neutral amino acid transport 0.7635150268306057 1.9045839690762132 0.0568341720678868 1.0 0.1921297862879858 3 P08195 1 +Porphyrin containing compound metabolic process 0.5542427570647804 1.9034612879521229 0.056980380418679 1.0 0.1923241012196059 18 P36551,O00264,P53004,O75027,P09601,P30043,Q7KZN9,P30519 8 +Phosphatidic acid metabolic process 0.8491321478565008 1.9011452703342149 0.0572829873767652 1.0 0.1932104339273717 4 Q9NPH0 1 +Negative regulation of protein secretion 0.8498926025371428 1.896923789590232 0.0578379971607212 1.0 0.1940710562132592 5 Q16836,Q16850 2 +Mammary gland development 0.5580475169475227 1.893289965856376 0.0583193188201422 1.0 0.1950964581262518 17 Q13505,Q9NQC3 2 +Response to peptide 0.37883095604032 1.8920890927396004 0.0584791113273832 1.0 0.1950964581262518 86 P09960,P11166,Q99523,P61006,P40939,Q9UQB8,Q8TBX8,P16435,P25054,P62993,P07196,Q9BSK2,P14618,P05067,O43865,Q16836,P31751,P08670 18 +Calcium ion transport 0.4275990559778923 1.8892197846904175 0.0588623847413407 1.0 0.1959285428887279 52 Q9HC07,Q13555,O14936,O95202,Q96GC9,P14373,P21796,O75844,P62942,O76024,P08195,Q8IYU8,Q8WWC4,O75323,P16615,Q96AQ8,Q9UM00 17 +Regulation of rac protein signal transduction 0.7598904399867003 1.8880759919601964 0.0590157493791947 1.0 0.1959285428887279 3 Q68EM7 1 +Insulin receptor signaling pathway 0.5217269959284105 1.8864722051295963 0.0592313505008181 1.0 0.1965403902981694 23 Q8TBX8,Q9UQB8,P11802,P25054,P62993,Q9HCD5,P31751 7 +Negative regulation of glucose import 0.6738653001464175 1.885690024510488 0.0593367379352733 1.0 0.196682175690424 2 P49840 1 +Negative regulation of calcium ion dependent exocytosis 0.6738653001464137 1.8856900245104684 0.059336737935276 1.0 0.196682175690424 2 P04899 1 +Fatty acid beta oxidation using acyl coa oxidase 0.8441524680944889 1.8806788395758147 0.0600156198413912 1.0 0.1981999270722011 4 O15254,Q15067 2 +Endoplasmic reticulum membrane organization 0.7577508429290061 1.8762613281555376 0.0606194044734047 1.0 0.1998784775651444 8 Q9NQC3,Q9P2W9,Q12981,Q8NHH9,Q00765 5 +Purine ribonucleoside metabolic process 0.7567291588519064 1.8714935208599068 0.0612767070904589 1.0 0.2012004012101994 8 O60725,P55263 2 +Ribonucleoside metabolic process 0.7567291588519064 1.8714935208599068 0.0612767070904589 1.0 0.2012004012101994 8 O60725,P55263 2 +C4 dicarboxylate transport 0.8036561359269788 1.867584347873471 0.0618200297939144 1.0 0.2026663953243837 6 Q9UBX3 1 +Erythrocyte maturation 0.670204978038069 1.8669506373282465 0.0619084815293919 1.0 0.2028504420884775 2 P18074 1 +Regulation of skeletal muscle cell differentiation 0.7546686195532771 1.864251804848701 0.0622863514403846 1.0 0.203769522846657 3 Q92841,P17844 2 +Fatty acid transmembrane transport 0.7791030895230883 1.863800007868145 0.0623497946582798 1.0 0.2038708389920212 7 P11166,P31751,O43772,P23786 4 +Protein maturation 0.4082335498429011 1.848030164526383 0.0645979792430644 1.0 0.2093681536850586 63 P49366,Q15005,Q8NEB9,Q15392,Q8TCT9,Q99797,O75844,Q5JRX3,Q92896,P62942,O76024,P42892,P67812,Q10713,O75503 15 +Detection of external biotic stimulus 0.7505019377418052 1.84520675666887 0.0650074680104202 1.0 0.2103695279223805 3 Q8WTV0 1 +Bile acid metabolic process 0.7264874677459052 1.843233091183713 0.0652949853639157 1.0 0.2110823471239254 9 P22059,O14734,O15118,Q9BZF3 4 +Regulation of histone h3 k14 acetylation 0.6654465592972195 1.8425454117521085 0.0653954103543403 1.0 0.2112981915617853 2 Q969T9 1 +Protein localization to microtubule end 0.6647144948755506 1.8387863963260735 0.0659466099110703 1.0 0.2126414057635849 2 Q15691 1 +Neuron maturation 0.8343991837167446 1.8329691433843431 0.0668071599999109 1.0 0.2142060012663129 5 P05067,Q9NZJ7 2 +Regulation of glycogen starch synthase activity 0.6625183016105468 1.8275024378965607 0.0676242599907277 1.0 0.216053488153582 2 P49840 1 +Response to interleukin 3 0.6625183016105468 1.8275024378965607 0.0676242599907277 1.0 0.216053488153582 2 P49840 1 +Cellular response to leucine 0.6621522693997086 1.825620774798144 0.0679074042825282 1.0 0.2166138983396894 2 Q9P2J5 1 +Acylglycerol homeostasis 0.8298768926040913 1.821802983851884 0.0684848848535244 1.0 0.2180038206284765 4 Q8WTV0 1 +Ceramide biosynthetic process 0.7450465620723534 1.8168263000950091 0.0692437144061197 1.0 0.2196624755137038 8 P04062,Q96G23,P27544 3 +Metal ion homeostasis 0.3914550972368557 1.8146480096284276 0.0695780195071662 1.0 0.2203421246582325 70 Q9HC07,Q96A33,O95202,P30519,Q8N511,Q9HD20,O75027,P62942,O76024,P09601,Q8IYU8,P05067,Q8WWC4,Q9Y487,P51572,P16615,Q96AQ8,Q9UM00 18 +Amino acid transmembrane transport 0.6399608749394715 1.811513033781191 0.0700614733490518 1.0 0.220993906694767 12 Q9Y619,O60831,Q15041,P30825,Q9H9B4,P08195 6 +L amino acid transport 0.6399608749394715 1.811513033781191 0.0700614733490518 1.0 0.220993906694767 12 Q9Y619,O60831,Q15041,P30825,Q9H9B4,P08195 6 +Endoplasmic reticulum tubular network organization 0.6951950524421161 1.8089820870019724 0.0704537863028862 1.0 0.2219057503135814 10 P57088,Q9NQC3,Q8NHH9,O95197 4 +Cellular response to biotic stimulus 0.4602034807541326 1.7998732991069444 0.0718806466184116 1.0 0.2247484877557252 33 Q8WTV0,Q96A33,O43823,O75844,O76024,Q86UE4,P08670 7 +Protein catabolic process in the vacuole 0.7872822599017655 1.7962091970675222 0.0724612525722414 1.0 0.2259243221338652 6 P04062,Q8N511 2 +Lysosomal protein catabolic process 0.7872822599017655 1.7962091970675222 0.0724612525722414 1.0 0.2259243221338652 6 P04062,Q8N511 2 +Alpha linolenic acid metabolic process 0.739210591425854 1.7934443214799392 0.0729019060159206 1.0 0.226910345051041 3 O14734 1 +Positive regulation of wound healing spreading of epidermal cells 0.6555636896046865 1.791702474088939 0.0731806380257285 1.0 0.2276650374259284 2 P42345 1 +Glutamate receptor signaling pathway 0.8208697945244113 1.7845044400668684 0.0743417339722549 1.0 0.2304777312976872 4 P05067 1 +Response to hydroxyurea 0.7367264738191139 1.782027332996811 0.0747447745507545 1.0 0.2312604369495167 3 Q5TDH0,O95251 2 +Negative regulation of establishment of protein localization 0.5358117771896065 1.777609406825865 0.0754680277506831 1.0 0.233163522745467 18 Q16850,O95429,P40939,Q16836,P60604 5 +Regulation of er to golgi vesicle mediated transport 0.819730244634781 1.772090286893319 0.0763795710358545 1.0 0.2348241659956391 5 Q9HCU5,Q9P2W9,Q6NUQ1 3 +Regulation of calcium ion import 0.818944661136573 1.7688212470225864 0.0769237098512638 1.0 0.2358042238507004 5 P21796,O14936 2 +Neuron recognition 0.7807075343087431 1.76742513038781 0.0771570573711217 1.0 0.2361993940234865 6 Q9NQC3 1 +Regulation of cardiac muscle cell proliferation 0.6508052708638382 1.7671499740700816 0.0772031150901859 1.0 0.2361993940234865 2 P06493 1 +Positive regulation of cardiac muscle cell proliferation 0.6508052708638382 1.7671499740700816 0.0772031150901859 1.0 0.2361993940234865 2 P06493 1 +Positive regulation of myotube differentiation 0.6508052708638372 1.767149974070075 0.077203115090187 1.0 0.2361993940234865 2 P42345 1 +Nucleotide transmembrane transport 0.7323160683845067 1.756950245920358 0.0789262901326595 1.0 0.2402808919657162 8 P41440,Q9H2D1,Q8TB61,Q9BSK2 4 +Amyloid beta formation 0.659726654396274 1.7513222386593803 0.0798904191476466 1.0 0.2417210054098655 11 O75298,Q9NQC3,O95197,P49840 4 +Glial cell proliferation 0.8123386308490295 1.7490725478623392 0.0802784798151592 1.0 0.2417210054098655 4 Q96G23 1 +Acute inflammatory response 0.8113672792156004 1.7450320158098858 0.0809792961611086 1.0 0.2431315262072884 4 Q9BQE5 1 +Sphingoid metabolic process 0.8129515995067574 1.743853900244701 0.0811845689169072 1.0 0.2435149181368102 5 Q06136,P04062 2 +Damp metabolic process 0.7281077353133889 1.7423366049582762 0.0814495617882515 1.0 0.24396438767099 3 P55263 1 +Purine deoxyribonucleoside monophosphate metabolic process 0.7281077353133889 1.7423366049582762 0.0814495617882515 1.0 0.24396438767099 3 P55263 1 +Regulation of golgi organization 0.7519989671917304 1.741085435228657 0.0816686039690504 1.0 0.2442665534624575 7 Q13190,Q9P2W9,P36507 3 +Tetrapyrrole catabolic process 0.8102564102564109 1.740409580455037 0.0817871244717305 1.0 0.2442719160007251 4 P30519,P09601,P30043 3 +Modified amino acid transport 0.809988406677709 1.7392941438082588 0.0819830368912253 1.0 0.2446242897353196 4 Q9H2D1,O43772 2 +Positive regulation of mitophagy 0.8085931140132341 1.7334853586313534 0.0830094376294068 1.0 0.2468655847642899 4 P21796 1 +Regulation of mitochondrial atp synthesis coupled electron transport 0.726107652874405 1.7331086909870532 0.0830763519222776 1.0 0.2469476029204826 3 Q9H3K2,P14635 2 +Endomembrane system organization 0.3416882427229711 1.7296552212357843 0.083691893583869 1.0 0.2478499900069107 146 Q8NEB9,P46379,P41440,P51790,Q00765,P16615,Q86XL3,Q9NQC3,Q96A33,Q14108,P48729,Q15629,P36507,Q13190,Q96GC9,Q9H6U6,P50570,O95197,P22059,Q9H4A6,P57088,O43760,P31751,Q9ULX6,Q8N1F7,Q9P2W9,O75844,Q9UQB8,O15027,O43681,Q9H267,P50402,Q9UEU0 33 +Regulated exocytosis 0.4571221981494582 1.728090011842442 0.0839720879367931 1.0 0.2478499900069107 32 Q9BRK5,P09601,Q68EM7,O14936,O43760,P16615 6 +Calcium ion transmembrane transport 0.4391949117302594 1.720596157944629 0.0853241311396701 1.0 0.2507794453627572 36 Q9HC07,O95202,Q96GC9,P21796,P62942,Q8IYU8,Q8WWC4,P16615,Q96AQ8,Q9UM00 10 +Activated t cell proliferation 0.7697398552091956 1.719255949615485 0.0855677771340359 1.0 0.2511659642539799 6 Q9HCL2 1 +Negative regulation of cell matrix adhesion 0.8068776275489568 1.718498898534727 0.0857056551874499 1.0 0.2514299547975752 5 O14936 1 +Er associated misfolded protein catabolic process 0.7688184796273485 1.7152008356573176 0.0863084117262058 1.0 0.2527258436647016 6 P46379,Q9BUN8 2 +Nerve development 0.7459152168172141 1.7133645840600449 0.0866454875536923 1.0 0.2530994295719564 7 Q9H061 1 +Collagen metabolic process 0.6513569435554093 1.706748149112553 0.0878688736050476 1.0 0.254607688257967 11 Q32P28,Q9H9C1,Q9H267,P08670 4 +Positive regulation of brown fat cell differentiation 0.6387262079062976 1.7046222072451789 0.0882649068890599 1.0 0.2553581038937873 2 Q16539 1 +Regulation of transport 0.3132551431292838 1.7017830356736492 0.0887960477651226 1.0 0.2558233412080363 270 Q8NEB9,Q32P28,Q16850,P50897,P21796,P14373,P41440,O43865,P61978,Q00765,P16615,P55786,Q13546,Q8WTV0,P61960,Q9HCU5,O60488,Q15154,Q9NR31,Q13432,P00367,O76024,P09601,P36507,P05067,O14936,P00813,O75323,P60604,Q9Y282,O75298,Q8NBU5,Q96GC9,Q9H6U6,Q16625,P50570,O95487,P62942,P22059,O95429,Q9H4A6,Q6NUQ1,P57105,P40939,P27105,P31751,P08183,Q9BWF3,Q9BZF3,Q9ULX6,Q13555,P61006,Q9P2W9,O75312,O95071,O75844,Q07666,P52789,Q96ST2,P51809,Q16836,P51572,P50402 63 +Response to peptide hormone 0.3700630290424156 1.698472863938631 0.0894185500745752 1.0 0.2572073767147644 77 P09960,P11166,Q99523,P61006,Q9UQB8,Q8TBX8,P16435,P25054,P62993,P07196,Q9BSK2,P14618,P40939,O43865,Q16836,P31751 16 +Protein targeting to peroxisome 0.799604679757928 1.6960040711672422 0.089885109067421 1.0 0.2580241036695334 4 P50542,O75381 2 +Peroxisomal transport 0.8010651111109017 1.6941887609175756 0.0902294198348627 1.0 0.2586576701932732 5 P50542,O75381,P28288 3 +Response to acid chemical 0.5236133672476406 1.693470132834375 0.0903660152721212 1.0 0.2589310104419797 18 Q9UQB8,Q8NEB9,Q99729 3 +Response to insulin 0.4085870630854371 1.6897607499741023 0.0910737356793394 1.0 0.2606375444557985 53 P11166,Q99523,P61006,Q8TBX8,Q9UQB8,P25054,P62993,Q9BSK2,P14618,P40939,Q16836,P31751 12 +Regulation of chaperone mediated autophagy 0.7158511795438924 1.685689425383642 0.0918556347103609 1.0 0.2620034869203299 3 P08621 1 +Response to arsenic containing substance 0.6471388989843649 1.68421938112257 0.0921392789941759 1.0 0.2625739416819957 11 P36551,O00571,P07196,P09601,P09651,Q9BWF3 6 +Ubiquitin dependent erad pathway 0.4677015013683597 1.6834025089302282 0.0922971979078006 1.0 0.2627238762991081 29 Q9BUN8,Q96A33,Q9UBU6,P46379,P51572,P60604 6 +Endoplasmic reticulum calcium ion homeostasis 0.6925783065575274 1.677173107931606 0.0935086360683179 1.0 0.264435683440045 9 Q96A33,O76024,P05067,P51572,P16615 5 +Negative regulation of nik nf kappab signaling 0.7133784023049847 1.6742329689858153 0.0940848223889445 1.0 0.26546719773384 3 O43657 1 +Retina morphogenesis in camera type eye 0.7132784694070737 1.673769786086401 0.0941758525020191 1.0 0.2654854072778069 3 P54802 1 +Eye photoreceptor cell development 0.7132784694070737 1.673769786086401 0.0941758525020191 1.0 0.2654854072778069 3 P54802 1 +Positive regulation of blood circulation 0.7947966288017578 1.6679219306876285 0.095331225524073 1.0 0.2675877179753472 5 P09493,P00813,P49840,P16615 4 +Positive regulation of rig i signaling pathway 0.7116628313970323 1.6662793660332134 0.095657784536371 1.0 0.2680980229104185 3 Q14671 1 +Regulation of protein tyrosine kinase activity 0.6664665001395503 1.6622796970846565 0.0964567066979951 1.0 0.2700959878010764 10 Q13432,O95684 2 +Positive regulation of smad protein signal transduction 0.7084708398748281 1.651469504656112 0.0986427426937051 1.0 0.2743815412632169 3 Q93062 1 +Response to ether 0.7885978083272385 1.649966366483173 0.0989498153162984 1.0 0.2748703276795228 4 Q9H4A6,Q14103 2 +Collagen biosynthetic process 0.7863211883279502 1.640425649935504 0.1009166957667859 1.0 0.2789015378737097 4 P08670 1 +Bone morphogenesis 0.7517886906499633 1.6400223579893605 0.1010005183113078 1.0 0.2789015378737097 6 O75844,P16435 2 +Intracellular lipid transport 0.638876933723779 1.639969129276719 0.101011585819104 1.0 0.2789015378737097 11 O15118,O43772,P23786 3 +Positive regulation of myelination 0.6262811127379242 1.6399144655212314 0.1010229527118216 1.0 0.2789015378737097 2 Q9UPY3 1 +Inositol lipid mediated signaling 0.5792078509959552 1.6364744602650845 0.1017403266287904 1.0 0.2801428818313799 13 Q8NEB9,Q05086 2 +Very long chain fatty acid metabolic process 0.7066126173691227 1.6351383840576663 0.1020200412407992 1.0 0.2805466003887009 8 P50542,P28288,Q15067,Q9P035 4 +Establishment of protein localization to organelle 0.3287544663285842 1.6351337709725011 0.1020210080738139 1.0 0.2805466003887009 162 Q99595,Q15005,O60830,Q9NS69,P46379,Q96P70,P55786,Q14108,Q15629,Q8TEX9,Q10713,Q8WWC4,Q99442,Q15070,Q8N4H5,O95429,Q9Y5M8,O43615,Q8N1F7,Q99523,O75312,Q5JRX3,O14925,O96008,O75381,P62072,O43681,P51572 28 +Phosphatidylcholine metabolic process 0.6082707006545932 1.6342573849855555 0.1022048176854955 1.0 0.2808303964594839 12 Q8WTV0,Q8NCC3,Q96N66 3 +Plus end directed organelle transport along microtubule 0.6248169838945863 1.63228395908183 0.1026196808420727 1.0 0.2814531919294594 2 Q9Y496 1 +Transition metal ion homeostasis 0.4989435249695444 1.6319970613035124 0.1026801052609787 1.0 0.2814959392263861 21 P30519,Q8N511,Q9Y487,P09601 4 +Endoplasmic reticulum to cytosol transport 0.6076990312794955 1.631034749461201 0.1028829873961021 1.0 0.2815251282828164 12 Q9BUN8,P51572,P60604,Q8TCT9 4 +Respiratory chain complex iv assembly 0.7489002932551322 1.6272300094085648 0.103688256442598 1.0 0.2831469656140193 6 Q9Y2R0,Q15070,O75880,O43819,Q7KZN9 5 +Regulation of clathrin dependent endocytosis 0.7020390324444812 1.621584071602504 0.1048924354600546 1.0 0.2850223752803376 3 Q13432 1 +Mitochondrial calcium ion transmembrane transport 0.6575837937889274 1.6165556911758137 0.1059742228508375 1.0 0.2872651861215709 10 P21796,Q8WWC4,O95202,Q96AQ8 4 +Regulation of protein exit from endoplasmic reticulum 0.7800012725803886 1.6139086584935525 0.1065472403047556 1.0 0.2885692729220257 4 P51572,P60604 2 +Folic acid containing compound catabolic process 0.6196925329429027 1.6055492388455894 0.1083729862505409 1.0 0.2921277834610974 2 Q9NRN7 1 +Regulation of mitophagy 0.7427141190373754 1.5997936857470485 0.1096443600521637 1.0 0.2943971880101107 6 P21796 1 +Gliogenesis 0.4065108794637454 1.5996158947922277 0.109683820126736 1.0 0.2943971880101107 45 Q9NQC3,Q96G23,Q96N66,O75306,P05067,P31751,P08670 7 +Phospholipid biosynthetic process 0.4225910178690469 1.5992887611003823 0.1097564556214691 1.0 0.2944662514493947 38 Q8NEB9,P35790,Q9HCL2,Q96N66,Q8TBX8,Q9BXW7,P48651,P22059,Q96BW9,Q86YN1,O15269,Q10713,Q9NPH0,Q9NTJ5,Q92643 15 +Ceramide metabolic process 0.543445492741276 1.5988176816449264 0.1098611190578735 1.0 0.2946211471359804 15 Q8NCC3,Q96G23,P27544,O95470,P04062 5 +Regulation of establishment of protein localization 0.340776257459798 1.5942308617257968 0.1108843365697846 1.0 0.2966049701683461 109 Q8NEB9,Q32P28,Q16850,P55786,P61960,O60488,Q15154,P00367,P60604,Q9Y282,Q9H6U6,P22059,O95429,Q9H4A6,P40939,P31751,P61006,O75312,Q16836,P51572,P50402 21 +L alpha amino acid transmembrane transport 0.6296838378388587 1.5905471381299516 0.1117115291371309 1.0 0.2981396565332388 11 Q9Y619,O60831,Q15041,P30825,P08195 5 +Protein hydroxylation 0.5420468719717704 1.5898855197691393 0.111860612194742 1.0 0.2983266454369545 15 Q32P28,Q9H9C1,Q9H267 3 +Glycoside catabolic process 0.7395782269252598 1.5858661149576825 0.1127696839043901 1.0 0.2999966861414775 6 Q9NUJ1,P04062,P08236,Q9BTY2 4 +Negative regulation of macroautophagy 0.6739788449565062 1.5851179808343612 0.1129395309731839 1.0 0.3000476872258933 9 O15118 1 +Cellular response to increased oxygen levels 0.7159200041521432 1.575820291277256 0.1150672246924262 1.0 0.3035443084909578 7 Q9Y487 1 +Cellular transition metal ion homeostasis 0.5105886767097884 1.571576179614775 0.1160488743666223 1.0 0.3053456970970893 17 Q9Y487,Q8N511,P09601 3 +Cartilage development involved in endochondral bone morphogenesis 0.7698501712122441 1.5712227515176471 0.1161309171267819 1.0 0.3054335558114524 4 O75844 1 +Lipid import into cell 0.735845786083265 1.5692724045880286 0.1165844794556916 1.0 0.3060253962637885 6 P31751 1 +Er overload response 0.7712992215821486 1.5690295087365282 0.1166410633303942 1.0 0.3060253962637885 5 O76024,Q96A33 2 +Lipid modification 0.4034370005801566 1.5677170158035478 0.1169471887901991 1.0 0.3063095209261365 45 P28288,Q15067,Q96N66,P50542,O15254,A1L0T0,P16435,P23786,P31751,Q13011,Q10713,Q9BWD1,P40939,P04062,Q16836,O14734 16 +Hormone metabolic process 0.4707260024623161 1.5665583390147493 0.1172179622182991 1.0 0.3063095209261365 25 O95470,Q9UBM7,O75844,P16435,P42892 5 +Response to oxygen levels 0.3972554168765526 1.5661408580013376 0.1173156446957037 1.0 0.3063675613143212 53 P11166,Q8N511,O75306,P09601,Q96A26,P30519,Q9Y487,P55786 8 +Bile acid biosynthetic process 0.6918870558440677 1.5648391685458387 0.1176206251041149 1.0 0.3069086801345111 8 P22059,O14734,Q9BZF3 3 +Macromolecule deacylation 0.4703951991583472 1.5639287715887469 0.1178342968234518 1.0 0.3072222521507785 25 P23246,O43823,P50897,Q13363,Q9NUJ1,Q96PK6,Q9ULX6 7 +Toll like receptor signaling pathway 0.5955979563001568 1.5626231047508272 0.1181412705297377 1.0 0.3074215769328109 12 Q9NQC3,Q9NPR9 2 +Receptor localization to synapse 0.6464959678802201 1.5592569412431092 0.1189355786110542 1.0 0.3090552825000821 10 O15400,P61006,Q14168 3 +Lipid homeostasis 0.4732269761287119 1.5573087436299793 0.119397200478803 1.0 0.3098542510815784 24 Q8WTV0,Q9NQC3,Q9HCL2,O15254,Q5BJF2,O15118 6 +Regulation of cholesterol biosynthetic process 0.7665036892855701 1.557126423232841 0.1194404727010862 1.0 0.3098542510815784 4 P16435 1 +Protein depalmitoylation 0.7660923201477179 1.5553928228804113 0.1198525423854093 1.0 0.3103813764624655 4 Q9NUJ1 1 +Lipoprotein localization 0.7679836436301504 1.5550242141970212 0.1199403025323258 1.0 0.3103813764624655 5 A6NIH7,Q13432 2 +Regulation of fc gamma receptor signaling pathway involved in phagocytosis 0.6090775988287013 1.550039837610195 0.1211319545557458 1.0 0.3123065341687773 2 Q9UKG1 1 +Regulation of long term neuronal synaptic plasticity 0.7646696071386321 1.5493958708127546 0.1212865857864913 1.0 0.3125768413660068 4 P05067 1 +Calcium import into the mitochondrion 0.709667217887791 1.5469790287087204 0.1218683026548332 1.0 0.3135611492078046 7 P21796,Q8WWC4,Q96AQ8 3 +Negative regulation of translational initiation 0.7092753397415672 1.5451696840994598 0.1223052251591008 1.0 0.3143264978213356 7 P60228 1 +Negative regulation of neuron projection development 0.5059621934789249 1.5397178525115227 0.1236291432484146 1.0 0.3171817577905791 17 Q9NQC3,Q96G23,Q9NR77,Q05086,P08670 5 +Endochondral bone morphogenesis 0.7628577896686994 1.5333491356908853 0.1251898540606817 1.0 0.3200089184824755 5 O75844 1 +Synaptonemal complex organization 0.7272550052546534 1.531013218307658 0.1257661258182183 1.0 0.321035947111129 6 P46379 1 +Lipoprotein catabolic process 0.7619992905327472 1.5297162425685176 0.1260869813984615 1.0 0.321386142598271 5 Q9NUJ1 1 +Establishment of protein localization 0.3185360600141853 1.5250419321840925 0.1272486391290128 1.0 0.3236900147698309 450 Q99595,Q8NEB9,A6NIH7,Q16850,O60830,O60725,Q9H9C1,Q9NS69,P46379,P55786,Q14108,P43307,Q13432,P00367,P60604,Q9Y282,Q15070,Q9HD20,Q8N4H5,P31751,Q9P2W9,Q14168,Q9BTX1,P62072,O75381,Q32P28,P24390,O15118,O43865,Q96PC5,Q9BUN8,Q96A33,Q8TCT9,Q15629,Q8TEX9,Q13190,Q9ULJ7,P22059,O95429,Q9Y5M8,P61006,Q5JRX3,A0AVF1,O43681,P51809,Q16836,P51572,Q9H267,Q9UEU0,P50897,P35606,Q96P70,O43823,Q10713,Q8WWC4,Q99442,Q8TD16,Q8NBU5,Q96GC9,Q9H6U6,O95487,Q9H4A6,Q6NUQ1,P40939,O43615,Q13555,Q8N1F7,Q8NFH4,Q99523,O75312,O14925,O96008,O15126,O15027,Q9BZG1,P50402,Q15005,Q8TB36,Q9Y3E0,Q9Y679,P61960,Q9HCU5,O60488,Q15154,Q9NR31,Q969Q5,O15127,O75298,O15400,Q99797,P50570,Q9P0J0,P57105,P50542 94 +Histone deacetylation 0.4986939829208519 1.519620244325381 0.1286064469051397 1.0 0.3259552982117349 18 Q13363,P23246,O43823,Q9ULX6 4 +Positive regulation of peptidyl tyrosine phosphorylation 0.5877350231208254 1.5179793637177823 0.1290196010288198 1.0 0.3264752338810684 12 Q13432 1 +Metal ion transport 0.352475676120465 1.516814881117475 0.129313428820996 1.0 0.326823553195738 84 Q9HC07,P21796,P14373,O75027,Q8IYU8,O43865,P16615,Q96AQ8,O76024,O14936,Q8WWC4,O75323,Q9UM00,O95202,Q96GC9,P50570,Q9HD20,P62942,O15173,P27105,Q13555,O75844 22 +Sphingosine biosynthetic process 0.7564446228312018 1.5146872424262916 0.1298516267011553 1.0 0.3278077851012304 4 P04062 1 +Proteoglycan biosynthetic process 0.7583401717352116 1.5142237069600653 0.1299691109023808 1.0 0.3278077851012304 5 Q8NCH0,Q96L58 2 +Proteoglycan metabolic process 0.7583401717352116 1.5142237069600653 0.1299691109023808 1.0 0.3278077851012304 5 Q8NCH0,Q96L58 2 +Regulation of hormone levels 0.3928934138393642 1.5124455234694452 0.1304205613425895 1.0 0.328563516897583 51 O95470,Q9UBM7,O75844,P16435,P00367,P22059,Q53GQ0,P42892,P40939,P51809,Q16836 11 +Protein localization to extracellular region 0.3929422372021249 1.5109873890418273 0.1307916639326634 1.0 0.3293662519732294 50 Q96PC5,Q32P28,Q8NEB9,Q16850,P61006,Q9HCU5,P00367,P22059,Q9H4A6,P40939,Q16836,Q13555 12 +Regulation of t cell proliferation 0.4970095855361442 1.5077795857424483 0.1316109485903474 1.0 0.3306336675671072 18 Q9HCL2,P30825,P23396,Q96J02 4 +Long chain fatty acid transport 0.542072697008632 1.5057407945024837 0.1321337272250689 1.0 0.3311519119836257 14 P11166,P31751,O43772,P23786 4 +Copper ion homeostasis 0.752209020657989 1.4967886134924018 0.1344482700152351 1.0 0.3349469202998597 4 P05067,O43819 2 +Cellular copper ion homeostasis 0.752209020657989 1.4967886134924018 0.1344482700152351 1.0 0.3349469202998597 4 P05067,O43819 2 +Regulation of receptor mediated endocytosis 0.4952724990202916 1.4955573689932855 0.134769039465137 1.0 0.3354797897550081 18 P50897,Q8NBU5,Q13432,P41440,P05067,P61978 6 +Negative regulation of amyloid precursor protein catabolic process 0.6770028108372159 1.4934423249752784 0.1353214408256904 1.0 0.3364546556450235 8 Q9NQC3 1 +Respiratory chain complex iii assembly 0.7527534371509537 1.490544585204907 0.1360811024962616 1.0 0.337273502682278 5 Q9BSK2,Q69YU5 2 +Intracellular transport 0.3155788375573167 1.490137786885374 0.136188010401334 1.0 0.337273502682278 482 Q99595,Q8NEB9,O60830,O60725,Q9H9C1,Q9NS69,P23786,P46379,P45880,P55786,Q14108,P43307,O75431,P60604,Q9Y282,Q15070,O75964,Q8N4H5,Q9UBX3,P31751,Q9P2W9,O75844,Q9NZJ7,Q14168,O43772,P62072,P07602,Q96RQ1,O75381,P24390,O15118,O43865,P16615,Q96PC5,Q9BUN8,Q8TCT9,Q5SNT2,Q15629,Q8TEX9,P05067,Q13190,O75503,Q9ULJ7,P22626,P22059,O95429,Q9Y5M8,Q9BWF3,Q9ULX6,P61006,Q5JRX3,Q07666,A0AVF1,O43681,P51809,P51572,Q9H267,Q9UEU0,P14373,P35606,Q96P70,Q10713,Q8WWC4,Q9NUL3,Q99442,Q8TD16,Q9H6U6,O95487,Q6NUQ1,O43615,O60313,Q8N1F7,Q99523,O75312,O14925,O96008,O15027,P50402,Q15005,Q8TB36,P07196,Q96EK5,Q9Y679,Q00765,P61960,P23246,P28288,Q9HCU5,Q15154,Q9NR31,Q969Q5,P36507,P09651,O75298,O15400,Q99797,Q9P0J0,P57105,P50542 99 +Vacuolar localization 0.5262818544939154 1.4887643399036905 0.1365494357124166 1.0 0.3380352355688295 15 P51809,P09601,Q9H267,Q9H0B6 4 +Negative regulation of mrna splicing via spliceosome 0.5257920215214473 1.4856099850368014 0.1373823123991551 1.0 0.3390559405390444 15 P22626,Q13242,P98175,P38159,P61978 5 +Positive regulation of response to endoplasmic reticulum stress 0.6963462539188153 1.4853625415745015 0.1374478127862166 1.0 0.3390559405390444 7 P46379,P51572 2 +Crd mediated mrna stabilization 0.6747580905277822 1.482647548672554 0.1381680770283302 1.0 0.3398804586813968 8 O60506,Q14103 2 +Negative regulation of nuclear transcribed mrna catabolic process deadenylation dependent decay 0.6747580905277822 1.482647548672554 0.1381680770283302 1.0 0.3398804586813968 8 O60506,Q14103 2 +Atp synthesis coupled electron transport 0.4138306875115157 1.4814492866750817 0.1384868892916351 1.0 0.340415305784215 36 P13073,O95168,O14949,O75306,Q9H3K2,O96000,Q9Y6M9,O43676,Q9UDW1 9 +Connective tissue development 0.4837043693194202 1.4806609418176029 0.1386969469765486 1.0 0.3407824160728949 20 P04818,O75844,Q92896,P11802,P16435,Q8N0X7,O15173 7 +Response to misfolded protein 0.6742827977422252 1.4803610147360056 0.1387769281805586 1.0 0.3407824160728949 8 P46379,Q9BUN8 2 +Mitochondrial cytochrome c oxidase assembly 0.7486258702821826 1.4730314505645552 0.1407425555459633 1.0 0.3448796891949875 5 Q9Y2R0,Q15070,O75880,O43819 4 +Regulation of leukocyte proliferation 0.4668929194646451 1.4691117514244652 0.1418024808797267 1.0 0.3468355496290418 23 Q9HCL2,P23396,P30825,Q96J02,P00813 5 +Cristae formation 0.6719342726567391 1.4690583735888816 0.1418169569763858 1.0 0.3468355496290418 8 O95202,Q5XKP0,Q9NX63,Q6UXV4,Q9Y4W6,Q16891 6 +Vacuolar transport 0.4008211317036763 1.4665328955741044 0.142503166204361 1.0 0.3481069561988242 42 Q14108,Q9H9C1,Q9NZJ7,O15118,P07602,P51809,Q9H267 7 +Regulation of mrna splicing via spliceosome 0.3781354500776139 1.460343067733035 0.1441958111814922 1.0 0.3518310542547254 61 P98175,P61978,Q15637,Q9UHX1,P84103,P14866,P09651,P62995,Q96EP5,P22626,P38159,Q9BWF3,O75525,Q13242,Q07666,Q15287,P98179,Q8IY67,Q13595,P31483 20 +Protein processing involved in protein targeting to mitochondrion 0.6671955804484878 1.458788592696981 0.1446233032457293 1.0 0.3527370232232669 3 Q10713 1 +Lysosomal transport 0.4080153125340049 1.4583766484833256 0.1447367535577162 1.0 0.3528766364409096 38 Q14108,Q9H9C1,Q9NZJ7,O15118,P07602,P51809 6 +Regulation of hormone biosynthetic process 0.666309354876388 1.454631192417065 0.1457713907819513 1.0 0.3552611767581873 3 P16435 1 +Negative regulation of cellular response to insulin stimulus 0.7442164841553821 1.4543060060768442 0.1458614860434564 1.0 0.3553428053476209 5 Q8TBX8,Q9HCD5 2 +Iron ion homeostasis 0.5204823720688831 1.4513722094805912 0.1466762438824549 1.0 0.3567739089864595 15 P30519,Q8N511,Q9Y487 3 +Entry into host 0.4352465608650709 1.4468767029330112 0.1479314591448819 1.0 0.3594093268233625 30 Q8WTV0,Q14108,Q9BTY2,P14373,O15118,Q12899,Q96J02 7 +Regulation of production of small rna involved in gene silencing by rna 0.7083830734887391 1.4466705627878491 0.1479892128745734 1.0 0.3594105525828132 6 O75844,Q13546,P36507 3 +Cytosolic calcium ion transport 0.463475793995478 1.4426216363976303 0.149127085010116 1.0 0.3614748415805052 23 O95202,P21796,P62942,Q8WWC4,P16615,Q96AQ8 6 +Protein quality control for misfolded or incompletely synthesized proteins 0.6017089820402333 1.4390614277008158 0.1501331193651638 1.0 0.3633522449400534 11 P46379,Q9BUN8 2 +Positive regulation of leukocyte proliferation 0.5306811407533562 1.4347409102129218 0.1513609417416686 1.0 0.3659006516188661 14 P00813,Q9HCL2,P30825,P23396 4 +Positive regulation of carbohydrate metabolic process 0.6842906700996503 1.4294153260301632 0.1528848959842248 1.0 0.3683628744409187 7 P31751 1 +Chromosome organization involved in meiotic cell cycle 0.5149022556690842 1.4153037267488218 0.1569794628017096 1.0 0.3747213184293281 15 P46379,Q9BTX1 2 +Divalent inorganic cation homeostasis 0.3840642332816746 1.4136164089328027 0.1574745607311958 1.0 0.375375816834919 49 Q9HC07,Q96A33,Q9HD20,P62942,O76024,P05067,Q8WWC4,P51572,P16615,Q96AQ8,Q9UM00 11 +Nervous system process 0.340900312932204 1.4115274123122823 0.1580891586545334 1.0 0.376368501339841 90 O00264,P53634,Q14108,P50897,Q8NBU5,O75844,Q9UQB8,Q14168,Q13432,Q8N0X7,O76024,Q9H6K4,O43924,Q9Y6M9,P62072,P05067,P04062,Q05086 18 +Small molecule biosynthetic process 0.326584253293544 1.408295224221097 0.1590436692361629 1.0 0.3780674575784291 131 P09960,Q16850,P37268,Q9BY49,Q15392,P55263,P16435,P00367,Q15125,Q9UBX3,P22059,Q8NCG7,P04062,Q9BZF3,Q13126,Q15800,Q14739,P48449,O00767,Q9H7Z7 20 +Mitochondrion localization 0.500294722231376 1.4057987552839166 0.1597838917781604 1.0 0.3795396415373784 16 O60313,Q9BUK6,O75153,P07196 4 +Long chain fatty acid biosynthetic process 0.5808931185944411 1.40195415143741 0.1609289382969783 1.0 0.3816818566786663 2 O00154 1 +Response to oxidative stress 0.3434464051787238 1.4011529783111585 0.1611683320113202 1.0 0.3821052826159623 85 Q15392,Q99720,Q93062,O95168,Q15165,P04062,Q8N0U8,P23396,O75306,P09601,O43169,Q15233,P30519,Q05086,Q7Z2K6,P16615,P05067,Q13546 18 +Nuclear body organization 0.6547532906243427 1.4003613420683456 0.1614051401705203 1.0 0.3825222612270768 3 O75312 1 +Fatty acid transport 0.4857451011669333 1.3995938785831978 0.1616349681050439 1.0 0.3829223885899872 17 P11166,P31751,O43772,P23786 4 +Positive regulation of pattern recognition receptor signaling pathway 0.6367981156994766 1.3993543698921822 0.1617067429769825 1.0 0.3829479186757813 9 Q14671,Q9NQC3,O00571,P41440 4 +Nucleoside salvage 0.7307209732822201 1.3968979970320632 0.162444247018852 1.0 0.383855266726957 5 P55263 1 +Purine ribonucleoside salvage 0.7307209732822201 1.3968979970320632 0.162444247018852 1.0 0.383855266726957 5 P55263 1 +Import across plasma membrane 0.5246248535907151 1.3968564438788889 0.1624567447743747 1.0 0.383855266726957 14 P11166,P30825,P41440,P05023,P08195,P31751 6 +Receptor mediated endocytosis 0.3860338436855364 1.3966206094871092 0.1625276893695346 1.0 0.3838784175552816 46 Q7Z6M1,P50897,Q14108,Q13432,P62993,P41440,P05067,P61978,Q5VW38 9 +Neuron apoptotic process 0.3892261428013649 1.3942187140175295 0.1632515684354862 1.0 0.3854431540571579 44 P50897,O75312,Q99720,P07196,O76024,P09601,Q01105,Q96A26,P05067,P04062,P31751,Q15233 12 +Anatomical structure maturation 0.4524519232959912 1.393468217281282 0.1634782495319642 1.0 0.3858332520908539 24 P05067,Q15125,Q9NZJ7,O75503 4 +Cellular homeostasis 0.3273244827478245 1.3909803020927725 0.1642314000204752 1.0 0.3865934493170391 117 Q9HC07,P50897,O75027,P51790,Q9Y487,P16615,Q96AQ8,Q93050,Q9NQC3,Q96A33,O76024,P09601,P05067,Q8WWC4,Q8N511,O75503,Q9UM00,O95202,Q9HD20,Q15120,P62942,P22059,Q05086,Q9BWH2,P51572 25 +Posttranslational protein targeting to endoplasmic reticulum membrane 0.6549185170645836 1.3869657543306184 0.1654522055839793 1.0 0.3878380344350651 8 P46379,O43681 2 +Reticulophagy 0.7283726150771612 1.3868950876231805 0.1654737560020025 1.0 0.3878380344350651 5 Q9Y6I9 1 +Negative regulation of secretion 0.5216448143130832 1.3781825199301525 0.1681469427619153 1.0 0.3927181944417055 14 P40939,P09601,Q16836,Q16850 4 +Regulation of glucose import 0.6324244019328007 1.3773747053585397 0.1683964291259811 1.0 0.3931546232997062 9 Q16625,O75298,P52789,P31751 4 +Peroxisome fission 0.7251740564309417 1.3732650841489114 0.1696699529584533 1.0 0.3959596782198001 5 O00429,Q96HA9,O14734,P40855 4 +Amyloid beta clearance by cellular catabolic process 0.5754026354319244 1.373018931660664 0.1697464613461159 1.0 0.3959596782198001 2 P14735 1 +Clathrin dependent endocytosis 0.5615589975169571 1.3683900448181838 0.1711900186992316 1.0 0.3986390717335966 12 Q5VW38 1 +Histone arginine methylation 0.6462526440572143 1.360381251196206 0.1737093083882663 1.0 0.4031597183221945 3 Q86X55 1 +Thyroid gland development 0.5728404099560825 1.3595093174525743 0.1739852519959996 1.0 0.4036509283188788 2 P28482 1 +Positive regulation of toll like receptor signaling pathway 0.721530405297305 1.3577310026017524 0.174549055543645 1.0 0.4045105096725743 5 Q9NQC3 1 +Peripheral nervous system axon regeneration 0.6455092806103118 1.3568831432225408 0.1748183437548425 1.0 0.4049850782630632 3 Q96G23 1 +Positive regulation of autophagy of mitochondrion 0.6669748680692549 1.3488005769190337 0.1774010293653349 1.0 0.4090049134269193 7 P21796 1 +Negative regulation of nervous system development 0.5168082400173681 1.3478317516391622 0.1777125030096848 1.0 0.4090049134269193 14 Q9NQC3,Q96G23 2 +Regulation of post translational protein modification 0.6435339910258803 1.3475865469118855 0.1777913999270568 1.0 0.4090049134269193 3 Q32P28 1 +Regulation of anion transmembrane transport 0.6862436666058942 1.3472968628297626 0.1778846420920421 1.0 0.4090695176021394 6 P08183 1 +Aminoglycan metabolic process 0.5037752129732862 1.343136031804003 0.1792279301815185 1.0 0.4118009790099339 15 Q8NCH0,Q7LGA3,Q96L58,O60701,P08236,P54802,P06865 7 +Negative regulation of transport 0.3603161396863217 1.3402870583266897 0.1801520373128089 1.0 0.4128787150976784 66 Q16850,P21796,Q13432,P62942,O95429,P09601,P05067,Q16836,P31751,P60604 10 +Negative regulation of cell development 0.46906723863153 1.3399410703391124 0.1802645043139115 1.0 0.4128787150976784 19 Q9NQC3,Q96G23 2 +Positive regulation of jun kinase activity 0.7150939050028395 1.339368128537377 0.180450859709438 1.0 0.4130519105411875 4 P23396 1 +Regulation of cartilage development 0.7150312958910372 1.3391018977017124 0.180537502791497 1.0 0.4130519105411875 4 P16435 1 +Regulation of chondrocyte differentiation 0.7150312958910372 1.3391018977017124 0.180537502791497 1.0 0.4130519105411875 4 P16435 1 +Oligosaccharide lipid intermediate biosynthetic process 0.713273368991763 1.3316260728220406 0.1829830929063329 1.0 0.4175827877188746 4 Q86YN1,Q9BT22 2 +Regulation of leukocyte degranulation 0.7130575265881482 1.3307080897384922 0.1832850801383112 1.0 0.4181190890655225 4 P09601 1 +Positive regulation of catabolic process 0.3212133442475711 1.330285105661156 0.183424352658549 1.0 0.4182848114748895 134 P27544,P21796,P14373,O60506,Q8TBX8,P25054,P46379,P67809,Q92945,Q9NPI6,P48729,Q14103,P09601,Q86UE4,P05067,Q13190,Q9Y5A7,P53634,O43847,Q8NCG7,Q96J02,P04062,P31751,O15269,P51572 25 +Cartilage development 0.601760331327676 1.325923933757264 0.1848648943991846 1.0 0.4205006547239424 10 O75844,P16435 2 +Positive regulation of protein deacetylation 0.6808351058177312 1.322966264013046 0.1858465970873379 1.0 0.4221219017779695 6 Q13363,Q9ULX6 2 +Positive regulation of histone deacetylation 0.6808351058177312 1.322966264013046 0.1858465970873379 1.0 0.4221219017779695 6 Q13363,Q9ULX6 2 +Establishment of protein localization to mitochondrial membrane 0.4874122056264616 1.3191428102063527 0.1871213733822687 1.0 0.4233326061599579 16 Q15070,Q9NS69 2 +Vascular transport 0.5793212494988432 1.3168341699967991 0.1878942164086781 1.0 0.4237068572606613 11 P41440,P08183,P30825 3 +Regulation of mrna metabolic process 0.3187458007256232 1.3130152543772704 0.1891778080317221 1.0 0.4259893396065823 140 Q969T7,P52272,O60506,P98175,P67809,O43865,P61978,Q15637,Q92945,Q9UHX1,Q9NPI6,P84103,Q99729,P35637,P14866,Q14103,Q13151,P09651,P62995,P08670,O95453,Q96EP5,P22626,P17844,P38159,Q92804,Q9BWF3,Q5JVF3,O75525,Q13242,Q07666,Q14671,Q15287,P98179,Q96ST2,Q8IY67,Q13595,P31483 38 +Negative regulation of response to wounding 0.7084061485358314 1.3109216041756069 0.1898842510384146 1.0 0.427120504485549 4 Q96G23 1 +Phosphatidylinositol biosynthetic process 0.5514207593396242 1.3101112058207276 0.1901582181219325 1.0 0.4274304666557439 12 Q8NEB9,Q96N66,Q8TBX8,Q10713,Q9NTJ5 5 +Respiratory electron transport chain 0.3742864012380651 1.3072258146945444 0.1911360306883367 1.0 0.4293209304691871 49 P13073,O95168,P43304,P21912,O14949,O75306,Q9H3K2,O96000,Q9Y6M9,P04062,O43676,Q9UDW1 12 +Sensory perception 0.4147219489312634 1.3065878092948988 0.1913527390942722 1.0 0.42957007957557 31 P50897,Q14108,Q13432,O76024,Q9H6K4,Q9Y6M9,O43924,P62072 8 +Astrocyte development 0.7091943332501065 1.3050886476144343 0.1918626639255054 1.0 0.430027836498444 5 P05067 1 +Oxidative phosphorylation 0.3699190824695637 1.3035690394939867 0.1923805625999117 1.0 0.4305758188956314 57 P13073,O95168,O75964,P14406,O14949,O75306,O96000,Q9Y6M9,O43676,Q9UDW1 10 +Phosphatidylserine metabolic process 0.7062325057503585 1.3016727666591468 0.1930282730212926 1.0 0.4314102876567017 4 Q8NCC3 1 +Organic hydroxy compound catabolic process 0.5496022176553922 1.299640837803816 0.1937240961507522 1.0 0.4325035119610322 12 P21964,Q8WTV0,P16930,Q10713 4 +Response to nitrogen compound 0.3053138371851105 1.2978152855770293 0.1943508157709266 1.0 0.4334402917974697 207 P09960,Q8NEB9,Q8TBX8,Q9UBU6,O15118,P25054,P46379,P62993,P41440,P07196,Q9BSK2,O43865,Q9HCD5,Q9BUN8,Q96A33,Q99729,P11166,Q8TCT9,Q99707,P16435,Q14103,O76024,P05067,P60604,P08670,P49721,Q9H4A6,P40939,P31751,Q05086,Q99523,P61006,Q13242,Q9UQB8,P14618,Q16836,P51572 37 +Collagen fibril organization 0.6158327488334636 1.2938100562696049 0.1957310382410333 1.0 0.4358990628156109 9 P13674,Q9H9C1,Q92791 3 +Homologous chromosome pairing at meiosis 0.6547590401888111 1.291787314735748 0.1964308095683424 1.0 0.437274884608938 7 P46379,Q9BTX1 2 +Regulation of amyloid fibril formation 0.6547048892157588 1.2915343807761122 0.1965184413031535 1.0 0.437274884608938 7 O15212,Q9UHV9,P61758,P05067,Q9NQP4 5 +Vesicle fusion with golgi apparatus 0.7038120965366639 1.2913724308507033 0.1965745656598168 1.0 0.437274884608938 4 Q13190 1 +Export from cell 0.3210011445969228 1.2904638019575083 0.1968896721453961 1.0 0.437274884608938 116 Q8NEB9,Q32P28,Q16850,P50897,P16615,Q96PC5,P00367,P09601,Q68EM7,O14936,Q9BRK5,P22059,Q9H4A6,P40939,O43760,P08183,Q13555,Q7Z6M1,P61006,P51809,Q16836,Q9UEU0 22 +Chemical synaptic transmission postsynaptic 0.5946669998461345 1.288677531114147 0.197510216994782 1.0 0.4378422112617378 10 P05067,Q14168 2 +Regulation of postsynaptic membrane potential 0.5946669998461345 1.288677531114147 0.197510216994782 1.0 0.4378422112617378 10 P05067,Q14168 2 +Selective autophagy 0.4352334534219652 1.281556013900205 0.1999984386464737 1.0 0.4416427006058959 25 P27544,P21796,Q9Y6I9,O15269,Q9Y679 5 +Amino acid import across plasma membrane 0.6709768691386885 1.2785793414878326 0.2010452285953208 1.0 0.4431748402813988 6 P08195,P30825 2 +Regulation of histone h4 acetylation 0.6704463663937814 1.2761895627551687 0.2018885172715645 1.0 0.444565454728475 6 O75844,Q13363,Q96ST2 3 +Regulation of immune response 0.3200772989129484 1.275061367089437 0.2022875220515707 1.0 0.4452878904066484 110 P14373,P46379,P41440,P01889,Q9NPR9,Q9NQC3,P23246,P23396,P09601,P00813,Q13153,Q96PK6,O15400,P49770,P62942,P28070,Q96J02,O43657,Q07666,Q8TCT8,P43243,P51809,Q15233 23 +Nucleotide excision repair dna incision 0.6278987428492309 1.2739511033156588 0.2026807456912593 1.0 0.4459627689584867 3 P19447 1 +Negative regulation of axonogenesis 0.6996352596046016 1.2735943474898068 0.2028072165301815 1.0 0.4459627689584867 4 Q9NQC3 1 +Regulation of secretion 0.3383478366848558 1.2733485647108376 0.2028943805830083 1.0 0.4459982217437417 76 Q32P28,Q8NEB9,Q16850,P61006,P00367,P22059,P09601,Q9H4A6,O14936,P51809,Q16836,P16615 12 +Pattern recognition receptor signaling pathway 0.4304154484180912 1.269608138736093 0.2042242488757486 1.0 0.4469127050498466 26 O43657,P41440,Q9NQC3,Q9NPR9 4 +Aspartate transmembrane transport 0.626510435737825 1.2674102596028842 0.2050086332078731 1.0 0.4479351968076157 3 Q9UJS0,Q9H936 2 +Negative regulation of mrna processing 0.4491862467147571 1.2605966897955083 0.2074541918861758 1.0 0.4520836245933075 21 P22626,Q13242,P98175,P38159,P61978 5 +Adult locomotory behavior 0.4908987778150198 1.2592658988036105 0.2079343061055907 1.0 0.452853760524135 15 P50897,O75844,O15118,P51790,P05067 5 +Phosphatidylglycerol metabolic process 0.5890581593747454 1.2591927526824924 0.2079607186350878 1.0 0.452853760524135 10 P40939,Q8NCC3,Q9HCL2 3 +Homologous chromosome segregation 0.6281072067754955 1.2570474947207166 0.2087364379307303 1.0 0.4538017651908943 8 P46379,Q9BTX1 2 +Cotranslational protein targeting to membrane 0.5153169059692353 1.2523654841708023 0.2104367173586676 1.0 0.4561136116334962 13 Q15629,P43307 2 +T cell activation 0.3692516265930465 1.2522607831518064 0.2104748539188019 1.0 0.4561136116334962 50 Q9HCL2,P23396,P24390,O96005,P30825,P62942,P17812,Q96J02,P00813,P04062 10 +Insulin metabolic process 0.5523426061493429 1.251352392985066 0.2108059381391811 1.0 0.4566734574319459 2 P14735 1 +Prostate gland development 0.6647786772972181 1.2506523473790574 0.2110613431794363 1.0 0.4567738129244363 6 P07602,Q9NZJ7 2 +Regulation of alcohol biosynthetic process 0.6956488170390653 1.2472234561772009 0.2123155745415914 1.0 0.4581660769598103 5 P16435 1 +Endoplasmic reticulum unfolded protein response 0.4602188977849837 1.246773363406723 0.2124806099179614 1.0 0.4581660769598103 18 P57088,Q9BUN8,Q7Z2K6,O76024 4 +Macromolecule depalmitoylation 0.695023761830978 1.244552366689399 0.2132963388592119 1.0 0.4586968828597226 5 Q9NUJ1,P50897 2 +Glial cell migration 0.5861292308651347 1.243785867833452 0.2135783829672921 1.0 0.4587892858830882 10 Q9NQC3,Q96G23 2 +Regulation of t cell apoptotic process 0.6926133655527024 1.2437010695988535 0.2136096022039291 1.0 0.4587892858830882 4 Q9HCL2 1 +Gastrulation with mouth forming second 0.6210545686510499 1.2417050322233671 0.2143454126086279 1.0 0.4598976419538504 3 Q4VCS5 1 +Organelle fusion 0.3806400899854412 1.2412304041372932 0.2145206460657283 1.0 0.4601163703452826 41 O15400,Q8TB36,P61006,Q99536,Q12981,Q86Y82,Q9BZG1,P31751,O60313,Q8N2A8,P51809,Q8IWA4,Q13190,Q9UEU0 14 +Carbohydrate transport 0.4758324806087246 1.240905494821273 0.2146406626502863 1.0 0.4602165574175197 16 P11166,O75298,Q99523,Q16625,P52789,P31751 6 +Purine deoxyribonucleotide metabolic process 0.6916330660625474 1.239527509611699 0.2151502075235933 1.0 0.4609941989191533 4 P55263 1 +Cerebral cortex radially oriented cell migration 0.661701296525876 1.236782863667941 0.2161677056184587 1.0 0.4621192318624387 6 Q9NQC3 1 +Telencephalon glial cell migration 0.661701296525876 1.236782863667941 0.2161677056184587 1.0 0.4621192318624387 6 Q9NQC3 1 +Hepatocyte apoptotic process 0.5494143484626697 1.2358998150209968 0.2164958058031014 1.0 0.4622995472217248 2 P55212 1 +Positive regulation of actin cytoskeleton reorganization 0.6192471399789568 1.2331896540741 0.2175050144240211 1.0 0.4639811350846091 3 Q9UQB8 1 +Tail anchored membrane protein insertion into er membrane 0.6229930307319805 1.232213213070862 0.2178694488331625 1.0 0.4640690776555686 8 P46379 1 +Negative regulation of phosphatase activity 0.583682012588146 1.2309083174806883 0.2183571564272197 1.0 0.4643185071750257 10 P62942,O95429,Q15257 3 +Peptidyl arginine methylation 0.6603470532057174 1.2306788208280393 0.2184430123596763 1.0 0.4643185071750257 6 Q6P2P2,Q7L592 2 +Peptidyl arginine n methylation 0.6603470532057174 1.2306788208280393 0.2184430123596763 1.0 0.4643185071750257 6 Q6P2P2,Q7L592 2 +Smad protein signal transduction 0.6033099630215317 1.230588727172665 0.2184767235098799 1.0 0.4643185071750257 9 Q8N1F7,Q93062,P08670,Q9UIQ6 4 +Response to auditory stimulus 0.5483162518301689 1.2301056549229177 0.2186575427348229 1.0 0.4644975225235184 2 Q8N2K0 1 +Phosphatidylinositol metabolic process 0.511026299524432 1.226276882866242 0.220094497605519 1.0 0.4665005923303467 13 Q8NEB9,Q96N66,Q8TBX8,Q10713,Q9NTJ5 5 +Heparan sulfate proteoglycan biosynthetic process 0.6882477516962812 1.225114764710402 0.220531982931581 1.0 0.4667612356908878 4 Q96L58,Q7LGA3 2 +Heparan sulfate proteoglycan metabolic process 0.6882477516962812 1.225114764710402 0.220531982931581 1.0 0.4667612356908878 4 Q96L58,Q7LGA3 2 +Negative regulation of lipase activity 0.6173508509696395 1.2242560669067672 0.2208556445358616 1.0 0.4670029425382752 3 P16435 1 +Carbohydrate transmembrane transport 0.4969501415091169 1.222733908936988 0.2214302151630631 1.0 0.4680602325904749 14 P11166,O75298,Q99523,Q16625,P52789,P31751 6 +Modulation of excitatory postsynaptic potential 0.6875218290766525 1.2220242486470938 0.2216984572124327 1.0 0.4684695100571029 4 P05067 1 +Positive regulation of ligase activity 0.6167286014074154 1.221324722597596 0.221963096419766 1.0 0.4685555882055452 3 P48507 1 +Regulation of ligase activity 0.6167286014074154 1.221324722597596 0.221963096419766 1.0 0.4685555882055452 3 P48507 1 +Leukocyte proliferation 0.3879201144220356 1.2202849735674488 0.2223568640942617 1.0 0.4690713685429351 35 Q9HCL2,P23396,P30825,P17812,Q96J02,P00813,P04062 7 +Negative regulation of transmembrane transport 0.472438004760583 1.2179194647279183 0.2232545785882003 1.0 0.4704908507474728 16 P21796,P62942 2 +Lipoprotein biosynthetic process 0.6007445731478601 1.2176263792815387 0.2233659852801077 1.0 0.470567669660576 9 Q8NEB9 1 +Peptidyl tyrosine modification 0.4130587228866688 1.2170528491564605 0.2235841087437478 1.0 0.4707112792398553 29 P05067,Q13432,O95684 3 +T cell proliferation 0.4300459228742098 1.214820890470574 0.2244344113762992 1.0 0.4718684643738804 24 Q9HCL2,P23396,P30825,P17812,Q96J02 5 +Glycoside metabolic process 0.5998601059964344 1.2131567126996183 0.225069910521801 1.0 0.4726454821706497 9 Q9NUJ1,P04062,P08236,Q9BTY2 4 +Glycoprotein biosynthetic process 0.3812759170467834 1.2122399631662226 0.2254205379958622 1.0 0.4727858876001672 39 Q9HC07,Q9BT22,O60502,Q8NCH0,Q7LGA3,Q96L58,O75352,P35610,O15118,Q86SF2,Q86YN1,O60701,Q9H4A6,P46977,O14734,Q9Y5P6 16 +Regulation of steroid biosynthetic process 0.5801314644946102 1.2122184217842178 0.2254287815754816 1.0 0.4727858876001672 10 Q15637,P16435,Q9UBM7 3 +Secretory granule organization 0.614319165660648 1.20997492239152 0.2262885158216372 1.0 0.4740204545639768 3 P22059 1 +Cellular response to peptide 0.3552909497143716 1.2070773274940123 0.2274023654605399 1.0 0.4752859191872081 62 P61006,Q9UQB8,P16435,P25054,P62993,P14618,P05067,O43865,P31751,P08670 10 +Cellular response to insulin stimulus 0.3712544194991548 1.2063717571410126 0.2276741808398732 1.0 0.475653413415216 44 P61006,Q8TBX8,Q9UQB8,P11802,P25054,P62993,Q9BSK2,P14618,Q9HCD5,P31751 10 +Positive regulation of macroautophagy 0.4579760068610311 1.2051154529552894 0.2281587350725584 1.0 0.4762926664655392 17 P21796,O15269,P27544,P09601 4 +Transition metal ion transport 0.5787210014340805 1.2047919441642747 0.2282836306777329 1.0 0.4762926664655392 10 Q9HC07,P50570,Q9HD20,O75027,O15173 5 +Cerebellar cortex development 0.5786559771562925 1.2044495501264487 0.2284158702618446 1.0 0.4764102436889902 10 P04062,O14949 2 +Positive regulation of multicellular organism growth 0.6827497067110274 1.201708795169199 0.2294763723391808 1.0 0.4773534345743463 4 Q9HCL2 1 +Negative regulation of protein localization 0.385426279895862 1.1964027189166402 0.2315394408301467 1.0 0.4800543624609185 35 Q16850,O95429,Q10713,P40939,Q16836,P60604 6 +Synaptic transmission glutamatergic 0.6813115162654648 1.195586876898302 0.2318578150911749 1.0 0.4802386549463531 4 Q8NBU5 1 +Sphingomyelin biosynthetic process 0.6811556554777465 1.194923449793169 0.2321169399914868 1.0 0.4806168038478082 4 P22059 1 +Positive regulation of nf kappab transcription factor activity 0.4315480557735038 1.1930010352863585 0.2328689675913107 1.0 0.4813801048858243 23 P23396,P14373,P41440,P05067,Q13546 5 +Cell cell junction maintenance 0.5406295754026352 1.1895603014877123 0.2342192568036556 1.0 0.48233954099792 2 Q96AC1 1 +Adherens junction maintenance 0.5406295754026352 1.1895603014877123 0.2342192568036556 1.0 0.48233954099792 2 Q96AC1 1 +Mitotic chromosome condensation 0.5305089447122023 1.1894692637836266 0.2342550590160335 1.0 0.48233954099792 12 Q9ULX6,Q96FF9 2 +Detection of biotic stimulus 0.6819685487460165 1.1887590295802706 0.2345345044953921 1.0 0.4824402422090668 5 P01889,Q8WTV0 2 +Neuronal stem cell population maintenance 0.6793250670887594 1.1871318576840089 0.2351756139883094 1.0 0.4831258195741514 4 Q15154 1 +Regulation of myeloid leukocyte mediated immunity 0.6322988547484405 1.18678435778539 0.2353126903627158 1.0 0.4832492869143376 7 P09601 1 +Cellular response to xenobiotic stimulus 0.4438246546337697 1.186494232021664 0.2354271779876158 1.0 0.4833262993480222 20 P07099,P27544,O43169 3 +Pathway restricted smad protein phosphorylation 0.6783715820680158 1.1830738091452169 0.2367798967264822 1.0 0.4853716316297067 4 Q93062 1 +Mitochondrial fusion 0.4791741734860101 1.182634487763916 0.2369540381770747 1.0 0.4853716316297067 15 Q8TB36,Q99536,Q9NX63,Q9Y6C9,Q9Y3D6,Q8NAN2,O60313,Q8IWA4,Q8N2A8 9 +External encapsulating structure organization 0.4385552257408485 1.1801710919672024 0.2379321740147024 1.0 0.4865596705095446 21 P13674,Q9H9C1,Q92791,P41440,Q53GQ0,P05067 6 +Purine nucleoside biosynthetic process 0.6490388190514305 1.179702789087243 0.2381184442179367 1.0 0.4867818209655383 6 P55263 1 +Stem cell proliferation 0.5542909993266679 1.1794697812306745 0.2382111628011225 1.0 0.4867818209655383 11 P04062,P48681,P08183 3 +Demethylation 0.4785914563056819 1.178820711473646 0.2384695752875951 1.0 0.4870240708053098 15 Q16850,P16435 2 +Response to iron ion 0.6794455910724664 1.177978076036108 0.2388053466634221 1.0 0.4875512085700696 5 P09601 1 +Cellular response to nutrient 0.6302860435659152 1.177369702504428 0.2390479771884779 1.0 0.4877293470228354 7 Q8TB36,P09601 2 +Negative regulation of amyloid fibril formation 0.6482703280597791 1.1762386171160897 0.2394995369037964 1.0 0.4883332551744183 6 O15212,P61758,Q9UHV9,Q9NQP4 4 +Immune response regulating signaling pathway 0.3621569169331032 1.1740598621423637 0.2403710489913362 1.0 0.4894743579525166 50 Q9NQC3,P23396,P49770,Q07666,O00571,P46379,P41440,Q14671,Q9NR50,Q96J02,O43657,P00813,Q13153,Q9NPR9 14 +Intrinsic apoptotic signaling pathway in response to dna damage by p53 class mediator 0.5720377769544207 1.1695917015685953 0.2421653184377514 1.0 0.4917725142493026 10 P46379 1 +Membrane protein proteolysis 0.5524764406963322 1.1694940886134138 0.2422046215448938 1.0 0.4917725142493026 11 O43847,Q8TCT9 2 +Regulation of regulated secretory pathway 0.4651450170861837 1.168469744731328 0.242617336376542 1.0 0.4923869876411304 16 O14936,P09601,P16615 3 +Secretion 0.3119564091477776 1.1682287197720769 0.2427145187330395 1.0 0.4923869876411304 131 Q8NEB9,Q32P28,Q16850,P50897,Q13505,P16615,Q96PC5,Q9HCU5,O60488,P00367,P09601,Q68EM7,O14936,P00813,Q9BRK5,P22059,Q9H4A6,P40939,O43760,Q13555,Q7Z6M1,P61006,O15126,P51809,Q16836,Q9H7Z7,Q9UEU0 27 +Cerebellar purkinje cell layer development 0.6464052387826501 1.1678315559871923 0.2428747166769835 1.0 0.4923869876411304 6 P04062,O14949 2 +Deoxyribose phosphate metabolic process 0.4881937240743769 1.167380051444638 0.2430569234992285 1.0 0.4923869876411304 14 P13051,P55263,Q9H773,P31350,P00813 5 +Sterol homeostasis 0.5265439031190376 1.166548456247928 0.2433927691403252 1.0 0.4925387216915284 12 Q8WTV0,Q5BJF2 2 +Fatty acid metabolic process 0.3254798528219 1.1662251028932873 0.2435234457041262 1.0 0.4925387216915284 87 P23786,Q9BY49,Q9P035,P51648,O95470,Q15067,Q8N4Q0,P16435,Q9BWD1,P07099,Q9HCL2,O15254,A1L0T0,Q15120,Q53GQ0,Q8NCG7,P40939,P31751,Q15800,Q8NCC3,Q13011,O00767,Q16836,Q9H7Z7 24 +Negative regulation of regulated secretory pathway 0.6743589743589755 1.1659988204896987 0.2436149223668113 1.0 0.4925650507629119 4 Q06787,P09601,P04899 3 +Positive regulation of autophagy 0.4175236336889212 1.1632570532768212 0.2447252246705886 1.0 0.4941733549314749 26 P27544,P14373,P21796,O15269,P09601,Q86UE4 6 +Deoxyribonucleoside triphosphate metabolic process 0.607900175283951 1.1588800043204932 0.2465051005015524 1.0 0.496489900849774 8 Q9H773 1 +Regulation of inflammatory response 0.3937913076482895 1.158275435583345 0.2467516524853017 1.0 0.4968270924639911 32 P51809,Q8NCG7,P28070,P05067,P04062,Q13546 6 +Pigment metabolic process 0.4059004733919134 1.1550145783346182 0.2480844566024342 1.0 0.4990305089875304 29 P36551,O00264,P53004,O75027,P09601,P30043,Q7KZN9,P30519,P00813,Q5T440 10 +Response to increased oxygen levels 0.5878845557476624 1.1526166766810024 0.2490677551635813 1.0 0.4997952789315402 9 Q9Y487 1 +Peptidyl lysine hydroxylation 0.6249761410467165 1.152534421333699 0.2491015335738753 1.0 0.4997952789315402 7 Q9H9C1,Q9H267 2 +Purine nucleotide transport 0.5681627135840468 1.1491760998591287 0.2504833738889642 1.0 0.5017659927488569 10 P41440,Q8TB61 2 +Protein localization to endoplasmic reticulum exit site 0.6701896145492685 1.148262628165634 0.2508601619881514 1.0 0.502200286020923 4 P51572 1 +Lipid oxidation 0.3761805073228912 1.146197891308226 0.2517132802127946 1.0 0.5031060086519976 38 Q15067,O15254,A1L0T0,P16435,P23786,Q13011,Q9BWD1,P40939,Q16836,P31751 10 +Meiotic chromosome segregation 0.446143579365511 1.145980839100897 0.2518030803176379 1.0 0.5031253145239117 18 P46379,Q9BTX1 2 +Regulation of erad pathway 0.6718497555357484 1.1455286077973583 0.2519902518514105 1.0 0.5031790079908256 5 P46379 1 +Natural killer cell activation 0.6051041912697144 1.1452929782596415 0.2520878137000504 1.0 0.5032137661077636 8 P46379 1 +Positive regulation of protein targeting to membrane 0.6408494936412599 1.1427925174295035 0.2531247462361214 1.0 0.5041615345400922 6 P31751 1 +Positive regulation of smoothened signaling pathway 0.6688448020444857 1.1425434130552037 0.2532282114637465 1.0 0.5042076471834446 4 P16435 1 +Positive regulation of t cell proliferation 0.5667115154281258 1.141529953356592 0.2536494545074288 1.0 0.5045663103287827 10 Q9HCL2,P30825,P23396 3 +Developmental maturation 0.3836638942890578 1.1391299424543415 0.2546489604338668 1.0 0.5054713331136762 34 Q15125,Q9NZJ7,P07196,P05067,P04062,Q8N2A8,O75503 7 +Intermediate filament bundle assembly 0.598992468675799 1.1378303375540952 0.2551913343945977 1.0 0.5057106052175773 3 P07197 1 +Negative regulation of autophagosome assembly 0.5300146412884423 1.1336354408851006 0.2569475002997217 1.0 0.5083436823937526 2 O75396 1 +Positive regulation of dna demethylation 0.5296486090775979 1.1317089324137437 0.2577568249309314 1.0 0.5096684557216968 2 Q93009 1 +Positive regulation of dopamine receptor signaling pathway 0.5292825768667733 1.1297825769539347 0.2585678515235281 1.0 0.5104649275963714 2 O14744 1 +Regulation of dopamine receptor signaling pathway 0.5292825768667733 1.1297825769539347 0.2585678515235281 1.0 0.5104649275963714 2 O14744 1 +Negative regulation of receptor mediated endocytosis 0.619027134755207 1.1247157784542474 0.2607094933448604 1.0 0.5134047048993203 7 Q13432 1 +Regulation of oxidoreductase activity 0.4465100938436607 1.1243375027552789 0.2608698742845221 1.0 0.5135594452048385 17 Q8WTV0,Q15070,Q8TCT9 3 +Import into cell 0.4353010197336551 1.1230906625923205 0.2613989913773049 1.0 0.5141174398078698 20 P11166,P30825,P41440,P05023,P08195,P31751 6 +Mitophagy 0.4936120862786888 1.1201959879760222 0.2626302532700379 1.0 0.5152246781119445 13 P21796 1 +Regulation of response to endoplasmic reticulum stress 0.4383548635038062 1.116359772992504 0.2642681653211136 1.0 0.5176616421784956 19 P46379,O76024,P51572,P57088 4 +Cellular iron ion homeostasis 0.5428123397573791 1.1163485969745537 0.2642729473052052 1.0 0.5176616421784956 11 Q8N511,Q9Y487 2 +Histone h4 r3 methylation 0.5252562225475934 1.1086034586694722 0.2676012854241465 1.0 0.5232017657716626 2 O14744 1 +Regulation of p38mapk cascade 0.5252562225475923 1.1086034586694662 0.2676012854241492 1.0 0.5232017657716626 2 P15311 1 +Determination of adult lifespan 0.6323355992049478 1.1044412019598238 0.2694017961856743 1.0 0.5260667111830989 6 O75844 1 +Insulin like growth factor receptor signaling pathway 0.5241581259150835 1.1028310277706908 0.2701005510444871 1.0 0.5264798099146628 2 P11717 1 +Mitochondrion distribution 0.6618443230607447 1.1028181972469226 0.2701061239947611 1.0 0.5264798099146628 5 O75153 1 +Membrane protein ectodomain proteolysis 0.5772853693748785 1.0990301777929472 0.2717549030571029 1.0 0.5286744818779298 9 O43847,Q8TCT9 2 +Regulation of histone deacetylation 0.6129076441031245 1.0961123778671362 0.2730295984559787 1.0 0.5302850752121328 7 Q13363,Q9ULX6 2 +Negative regulation of glycogen metabolic process 0.5898834474631067 1.09502742847169 0.2735046201979498 1.0 0.5307765086870879 3 P49840 1 +Long chain fatty acyl coa biosynthetic process 0.659285634302845 1.0919044005189125 0.2748751233033801 1.0 0.5329419469112479 5 Q53GQ0,O60488 2 +Dendritic transport 0.6293570767103271 1.0910325185546896 0.2752585739831374 1.0 0.5335206321290945 6 Q9NUL3 1 +Phospholipid metabolic process 0.3502523013695677 1.0895857496279957 0.2758956631865106 1.0 0.5337002098203911 58 Q8NEB9,P37268,Q8TBX8,Q96BW9,Q8WTV0,P35790,Q10713,Q9NPH0,Q8NHP8,Q9HCL2,Q96N66,P48651,P22059,Q86YN1,P40939,Q9NTJ5,Q92643,Q8NCC3,O15269,Q9BXW7 20 +Metencephalon development 0.4115136639543618 1.0885987168743236 0.2763308828741269 1.0 0.5337002098203911 25 O14949,Q9BRK5,Q14103,P54802,P04062 5 +Mitochondrial calcium ion homeostasis 0.5127014965829064 1.086477396953681 0.277267835711201 1.0 0.5349377604778489 12 Q8WWC4,O95202,P51572,Q96AQ8 4 +Purine containing compound transmembrane transport 0.6107551632385254 1.086055618415931 0.277454386134742 1.0 0.5351332215526606 7 P41440,Q8TB61 2 +Fat cell differentiation 0.4137959321206134 1.0843707721402172 0.2782004374882847 1.0 0.5360780683092239 24 Q99523,Q8N4Q0,Q9BRK5,Q13363,P31751 5 +Adult behavior 0.4369253089066108 1.079808680375232 0.2802273849471102 1.0 0.5391564580747649 18 P50897,O75844,O15118,P51790,P05067 5 +Regulation of nuclear transcribed mrna catabolic process deadenylation dependent decay 0.5358036081669761 1.0778029621068914 0.2811216973776569 1.0 0.5404658504244981 11 O60506,Q14103 2 +Peptidyl proline hydroxylation 0.6081840339940399 1.0740464407969252 0.2828018675881738 1.0 0.5424557653713923 7 P13674,Q32P28 2 +Regulation of blood pressure 0.4360680687489461 1.07365112430522 0.2829790747995078 1.0 0.5424557653713923 18 P42785,P42892,Q9UIQ6 3 +Regulation of hormone metabolic process 0.6254089358027157 1.07326737797124 0.2831511674525184 1.0 0.5426199723036967 6 O75844 1 +Purine containing compound salvage 0.6077580840644105 1.0720573335959276 0.2836942811597074 1.0 0.5434948724811239 7 P55263 1 +Positive regulation of mitochondrial membrane potential 0.6514053229598389 1.0684745052394211 0.2853065246612698 1.0 0.5457508719754576 4 P31751 1 +Lipid droplet organization 0.5711309728943209 1.0679299615531743 0.2855521061481783 1.0 0.5460542559848502 9 Q8N0X7,Q14534 2 +Positive regulation of cold induced thermogenesis 0.5092604159197343 1.0665696511786844 0.2861662110434186 1.0 0.5466162108018455 12 O00767,Q16836,P25054,P23786 4 +Histone h4 deacetylation 0.5172035139092277 1.0663149007685857 0.2862813158834658 1.0 0.5466162108018455 2 Q9H4L7 1 +Mhc class ii biosynthetic process 0.5172035139092229 1.066314900768561 0.2862813158834769 1.0 0.5466162108018455 2 Q96EB6 1 +Protein localization to golgi apparatus 0.623532855233589 1.0648296157602388 0.2869530405261562 1.0 0.5473993279924669 6 Q8TD16 1 +Positive regulation of cytoplasmic translation 0.5329892235576483 1.0623279912492678 0.2880868113292059 1.0 0.5488949928754946 11 O60506,P14618,Q14103 3 +Aminoglycan biosynthetic process 0.5877918526107717 1.0612117183682523 0.2885936950713028 1.0 0.5493605875250575 8 P06865,Q8NCH0,Q7LGA3,Q96L58 4 +Positive regulation of membrane potential 0.6512608651985943 1.0577054895587454 0.2901897317652522 1.0 0.5509195079210619 5 P31751 1 +Positive regulation of production of mirnas involved in gene silencing by mirna 0.6512543302737142 1.0576776607301732 0.2902024231753666 1.0 0.5509195079210619 5 Q13546,P36507 2 +Lipopolysaccharide mediated signaling pathway 0.6216844269088744 1.0565189368583536 0.2907311938419341 1.0 0.5511503318271048 6 Q8WTV0 1 +Cell maturation 0.4261527790028964 1.0549348448286489 0.2914551245607444 1.0 0.5517959203837013 20 P05067,P04062,O75503,Q9NZJ7 4 +Protein deneddylation 0.5684697053292955 1.0544878067596932 0.2916596401930897 1.0 0.552016647914446 9 Q7L5N1,Q9H9Q2,Q92905 3 +Cell adhesion molecule production 0.647682695321232 1.0526947630917447 0.292480909593261 1.0 0.5524164023999011 4 P41440 1 +Aminoglycan catabolic process 0.6492656266439795 1.049210567011149 0.2940812162731991 1.0 0.5533870499461131 5 P08236,P54802,P04066 3 +Glycosaminoglycan catabolic process 0.6492656266439795 1.049210567011149 0.2940812162731991 1.0 0.5533870499461131 5 P08236,P54802,P04066 3 +Dsrna processing 0.432499182087816 1.048011436628684 0.2946333377167662 1.0 0.5533870499461131 18 P22626,O75844,P17844,O00571,Q14671,Q15631,P36507,Q13546 8 +Sphingomyelin metabolic process 0.6487387542706275 1.046967959739671 0.2951143558154359 1.0 0.5535488275498376 5 P22059,Q9NXE4,O15269 3 +Endocytosis 0.3083764714144281 1.045963701155916 0.2955777917270079 1.0 0.5538924680703564 100 Q8NEB9,P50897,O15118,P62993,P41440,P61978,Q5VW38,Q9NX40,Q8WTV0,Q14108,Q13432,P05067,Q8NBU5,Q05086,Q7Z6M1,Q99523,O15126,Q9BZG1,P51809 19 +Regulation of protein neddylation 0.6460115044339516 1.0456152639356455 0.2957386991035098 1.0 0.5538924680703564 4 Q92564 1 +Neuron death 0.3404870954624747 1.044947021699748 0.2960474556378907 1.0 0.5541401092709236 63 P50897,Q15392,Q99720,O75312,P07196,O76024,P09601,Q01105,Q96A26,P05067,P04062,P31751,Q15233 13 +Regulation of mitotic cytokinesis 0.5124450951683746 1.0413790470644109 0.297699663087015 1.0 0.5564032405061864 2 Q9Y2S7 1 +Gmp metabolic process 0.4462229095957412 1.0399042632106388 0.2983843816150839 1.0 0.556688602609063 16 O14936,Q00013,Q14168,P55263 4 +Post anal tail morphogenesis 0.5120790629575502 1.0394627614640983 0.2985895681970356 1.0 0.5569059147774776 2 Q15363 1 +Protein catabolic process 0.2834830638221569 1.034822131801728 0.3007519851332212 1.0 0.5593429737968837 246 Q16850,P50897,Q9UBU6,P25054,P46379,Q9Y679,Q13546,Q9BUN8,Q96A33,O14773,Q8TCT9,P48729,Q9UIQ6,Q99436,O76024,Q8N511,Q13190,O75503,P60604,P53634,O60502,P49721,O95260,Q9NXV2,O43847,Q96K76,P28070,Q9UJX4,Q96J02,Q9NUJ1,P04062,Q05086,P20618,O75844,P28072,P48556,Q9UHG3,P51572 38 +Positive regulation of i kappab kinase nf kappab signaling 0.3765087314959451 1.0345560888758405 0.3008762699127232 1.0 0.5593429737968837 33 P14373,Q9Y3E0,P62942,Q8TB61,P09601,Q86UE4,O43657,Q13546 8 +Hematopoietic stem cell homeostasis 0.6432762641044418 1.0340346709953294 0.3011199550511849 1.0 0.5594646575351699 4 Q9NX40 1 +Organelle membrane fusion 0.4045087527401244 1.0314108373888615 0.3023482008601057 1.0 0.5611561532724757 25 O15400,P61006,P51809,Q86Y82,P31751,Q9BZG1,Q8IWA4,Q13190,Q9UEU0 9 +Regulation of anion transport 0.5273643440523774 1.0314105318012077 0.3023483441029362 1.0 0.5611561532724757 11 O43865,P08183 2 +Histone phosphorylation 0.4662690171328193 1.0285414821806131 0.3036951882850496 1.0 0.5629165609842165 14 O75844,Q9ULX6 2 +Hippo signaling 0.6149689939559022 1.0263516236449062 0.3047258720125294 1.0 0.5641607267751871 6 Q4VCS5 1 +Regulation of defense response 0.3178859894009837 1.0258304259018256 0.3049715217690372 1.0 0.5643459509905038 82 P01889,P53634,P23246,Q13546,O75844,P51809,Q8NCG7,P28070,P43243,Q96J02,P05067,P00813,P04062,Q13153,Q15233,O43657 16 +3 utr mediated mrna destabilization 0.6143424877204023 1.0235394979351726 0.3060528347045135 1.0 0.565283817674297 6 Q92945 1 +Regulation of neuron projection development 0.3442334244067045 1.0194324686396932 0.3079976982904862 1.0 0.5685414730572397 58 Q13555,Q32P28,Q96G23,Q9NQC3,Q14108,Q8WWV3,Q9UQB8,P07196,Q8N0X7,Q86X55,Q9NR77,Q9NUL3,Q05086,P08670 14 +Cellular carbohydrate catabolic process 0.4249842807767119 1.0185651981274042 0.3084094334290324 1.0 0.5687750253968232 19 Q9NUJ1,P08236,Q14108,P06737 4 +Cellular response to nitrogen starvation 0.5080527086383653 1.0184027122027026 0.3084866138063369 1.0 0.5687750253968232 2 O95352 1 +Peptidyl proline modification 0.3897696988962219 1.014813526304274 0.3101947247333414 1.0 0.5706235734637912 29 P13674,Q32P28,O75718,Q9NWM8,P62942,Q9Y680,Q15257 7 +Humoral immune response mediated by circulating immunoglobulin 0.5073206442166986 1.0145775521859628 0.3103072443143131 1.0 0.5706235734637912 2 Q9UQ84 1 +Negative regulation of interferon gamma production 0.5073206442166908 1.0145775521859208 0.3103072443143331 1.0 0.5706235734637912 2 P09429 1 +Lipid droplet formation 0.6383401305190148 1.0131577572281736 0.3109848141211153 1.0 0.5713674752860293 4 Q14534 1 +Regulation of multicellular organism growth 0.4997489914814841 1.011564825163669 0.3117461713139891 1.0 0.5723663949329831 12 Q9HCL2,O95470,P50542,O75844,P05067 5 +Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress 0.4633656924396351 1.0101539813853435 0.3124215229593445 1.0 0.5730009702421166 14 P46379,O76024 2 +Microtubule anchoring at microtubule organizing center 0.6105039560493871 1.0063195050356055 0.3142619007522129 1.0 0.5757035929157842 6 Q8TD16,Q86VS8,Q15154 3 +Skeletal system morphogenesis 0.4519486891212776 1.0041920670638258 0.3152860450958228 1.0 0.5765702857883995 15 O75844,O95470,P16435 3 +Regulation of cytoplasmic translation 0.4515478266069826 1.001564064370319 0.3165541842172548 1.0 0.5780815446045433 15 O60506,P14618,Q14103 3 +Protein hexamerization 0.6355216883601739 1.0012512192224037 0.3167053698364177 1.0 0.5780815446045433 4 O95202,O60701 2 +T cell apoptotic process 0.5218540781277033 1.0011443822577968 0.3167570107422155 1.0 0.5780815446045433 11 Q9HCL2,P24390,Q13546 3 +Paraxial mesoderm formation 0.5040263543191887 0.9973804300500672 0.3185798867770559 1.0 0.5802530410211623 2 Q12948 1 +Mesenchyme morphogenesis 0.5040263543191887 0.9973804300500672 0.3185798867770559 1.0 0.5802530410211623 2 Q12948 1 +Paraxial mesoderm morphogenesis 0.5040263543191887 0.9973804300500672 0.3185798867770559 1.0 0.5802530410211623 2 Q12948 1 +Positive regulation of synaptic transmission 0.439963866065589 0.9973516389032048 0.3185938567059487 1.0 0.5802530410211623 16 P05067,Q14168 2 +Microtubule anchoring 0.5208741110703138 0.995764601531551 0.3193645333380854 1.0 0.5812320807384015 11 Q8TD16,Q86VS8,O95684,Q15154,O75381 5 +Negative regulation of rna splicing 0.4281111066723486 0.9944642342366268 0.3199969094509509 1.0 0.582132888302831 17 P22626,Q13242,P98175,P38159,P61978 5 +Regulation of mrna catabolic process 0.3275251708842692 0.9895315020551152 0.3224031648806966 1.0 0.5854669156019388 69 Q969T7,P52272,O60506,P98175,P67809,Q92945,Q9P2K5,Q9NPI6,Q99729,P35637,Q14103,Q13151,P08670,O95453,Q13310,Q06787,Q9NQT5,Q92804,Q5JVF3,Q96B26,Q14671,Q9Y5S9,P07910 23 +Nucleobase containing small molecule biosynthetic process 0.5897484952674401 0.9881018868211566 0.3231027517945239 1.0 0.585746195716437 7 P55263 1 +Glycosyl compound biosynthetic process 0.5897484952674401 0.9881018868211566 0.3231027517945239 1.0 0.585746195716437 7 P55263 1 +Regulation of autophagy of mitochondrion 0.4717805674202487 0.9870713992061068 0.3236076376320445 1.0 0.5861912570042459 13 P21796 1 +Methionine biosynthetic process 0.6320614180715456 0.9866482393434206 0.3238151129803639 1.0 0.5861912570042459 4 Q13126 1 +Sulfur amino acid biosynthetic process 0.6320614180715456 0.9866482393434206 0.3238151129803639 1.0 0.5861912570042459 4 Q13126 1 +Methionine metabolic process 0.6320614180715456 0.9866482393434206 0.3238151129803639 1.0 0.5861912570042459 4 Q13126 1 +Autophagy of nucleus 0.501464128843341 0.984024145269888 0.3251036412034493 1.0 0.5876765503815881 2 O95352 1 +C terminal protein lipidation 0.501464128843341 0.984024145269888 0.3251036412034493 1.0 0.5876765503815881 2 O95352 1 +Meiosis i cell cycle process 0.4487898868335802 0.9834860738380844 0.3253682659875001 1.0 0.5879855998473016 15 P46379,Q9BTX1 2 +Bone development 0.4083577702985628 0.9827625685804128 0.3257243083587697 1.0 0.588459628165858 22 O75844,Q15125,Q32P28,P16435 4 +Protein maturation by protein folding 0.6051706351717889 0.982423822549153 0.3258910948684592 1.0 0.5885915689252552 6 P62942 1 +Regulation of protein folding 0.6307692307692321 0.9811994460858556 0.3264943972821785 1.0 0.5892947449160709 4 Q9H2J4,O14737,P08621 3 +Cellular response to topologically incorrect protein 0.382202201959689 0.9803887384764324 0.3268942665162244 1.0 0.5895553591464685 30 Q9BUN8,Q9Y679,P46379,O76024,P57088,Q7Z2K6 6 +Regulation of stress activated protein kinase signaling cascade 0.4006897718693867 0.9788992043686828 0.3276297853591656 1.0 0.5901207236711876 24 O75844,Q969S3,P36507,P05067,Q96J02,Q13546 6 +Regulation of response to extracellular stimulus 0.6326901386796165 0.978802167464223 0.3276777385660656 1.0 0.5901207236711876 5 O15164,Q9UMX5,P80303 3 +Regulation of smad protein signal transduction 0.6295834734722505 0.976201673684642 0.3289645340086042 1.0 0.5919287315867061 4 Q93062 1 +Autophagosome organization 0.4039988947627116 0.975660834617792 0.3292325668462352 1.0 0.5922412764070673 23 P04062,Q8NEB9,P16615,Q96GC9 4 +Negative regulation of blood circulation 0.563593923904299 0.9720854490138432 0.3310080404445403 1.0 0.5947534281370419 3 P16615 1 +Regulation of synapse assembly 0.6023529900513312 0.9698152335934788 0.3321385981755789 1.0 0.5955915793619778 6 P05067 1 +Negative regulation of developmental growth 0.5511719794252197 0.967267167586712 0.3334104923238417 1.0 0.5970270679592812 9 Q9NQC3 1 +Positive regulation by symbiont of entry into host 0.4981698389458346 0.9668784451658388 0.3336048031859104 1.0 0.5970270679592812 2 P19474 1 +Response to interleukin 12 0.4981698389458339 0.9668784451658348 0.3336048031859124 1.0 0.5970270679592812 2 Q08722 1 +Vitamin d metabolic process 0.6273142313477277 0.9666433582550424 0.3337223516378611 1.0 0.59706723385081 4 P04062 1 +Positive regulation of jnk cascade 0.6295417556249132 0.965468330023718 0.3343102911954898 1.0 0.5977784130234364 5 P05067,Q13546 2 +Regulation of lipid metabolic process 0.3464281677952535 0.964926845563866 0.3345814541158745 1.0 0.5980416079151015 45 Q8WTV0,Q96G23,Q96N66,Q9UBM7,O75844,Q9NZJ7,P16435,Q8NCG7,P07602,P31751 10 +Steroid hormone biosynthetic process 0.6011876346008478 0.96460386298748 0.3347432638123075 1.0 0.5980416079151015 6 Q9UBM7 1 +Face development 0.6291757131865846 0.9639190469180294 0.335086513748819 1.0 0.5983709223071139 5 Q12797,O95470 2 +Golgi organization 0.345608418358826 0.9638558198484656 0.3351182164434234 1.0 0.5983709223071139 46 Q9P2W9,Q96GC9,O15260,P48729,Q9H6U6,P50570,O15027,Q9Y3B3,Q9H4A6,P36507,Q13190,Q9UEU0 12 +Positive regulation of amyloid precursor protein catabolic process 0.600870761566006 0.963187194328506 0.3354535903140401 1.0 0.5986292325160727 6 Q96P70 1 +Regulation of t cell activation 0.3720789600237985 0.9592761659506098 0.3374196389876598 1.0 0.6012831375431531 32 Q9HCL2,P23396,P30825,Q96J02,P00813,O96005 6 +Response to staurosporine 0.5606005126327352 0.9581653189386486 0.3379794022728539 1.0 0.6019389184309155 3 P55210,P55212 2 +Cellular response to alkaloid 0.5606005126327352 0.9581653189386486 0.3379794022728539 1.0 0.6019389184309155 3 P55210,P55212 2 +Protein localization to cytoplasmic stress granule 0.5831062753242199 0.9572344398876442 0.3384489375674573 1.0 0.6024333513037985 7 P67809,P31483,Q9NPI6 3 +Regulation of release of cytochrome c from mitochondria 0.5490854819464658 0.956770525643092 0.3386830921456805 1.0 0.6024922163301687 9 P02545,O60313,Q9H3K2,Q96A26 4 +Regulation of catabolic process 0.2822013286507018 0.9554418455816538 0.3393543010459996 1.0 0.6033606066176114 282 Q8NEB9,P27544,Q16850,P21796,P14373,O60506,O15118,P25054,P46379,Q9Y487,Q92945,Q93050,Q8WTV0,Q99729,Q14108,P35637,Q14103,Q13151,P09601,Q9NZ45,P05067,Q86UE4,Q13190,P08670,O43847,Q8NCG7,Q92804,P04062,P31751,Q05086,P61006,O75844,Q9NZJ7,P07602,P51572 35 +Regulation of protein deacetylation 0.5641698369346816 0.9468640201052674 0.34370807412976 1.0 0.6086880929158346 8 Q13363,Q9ULX6 2 +Cellular hormone metabolic process 0.443125912291593 0.9463799726432536 0.3439548165620383 1.0 0.6089532821140655 15 P42892,O95470 2 +Negative regulation of ion transmembrane transport 0.4879556973089022 0.9434674890757148 0.3454418369196173 1.0 0.6108219635564954 12 P21796 1 +Negative regulation of phosphoprotein phosphatase activity 0.5634435622041246 0.9433600282547204 0.3454967812343286 1.0 0.6108219635564954 8 P62942,O75663,Q15257 3 +Amino acid import 0.5629136590342269 0.9408040126830828 0.3468053041801098 1.0 0.612529501466828 8 P08195,P30825,Q9H9B4 3 +Positive regulation of cell junction assembly 0.5627760514308366 0.9401403335200896 0.3471455823859468 1.0 0.612529501466828 8 Q9H2P0,P41440,P60903,Q9Y2S7,Q9NUL3,O75955 6 +Chemokine production 0.578647148265093 0.9365506732332648 0.3489897352351725 1.0 0.6147467895079722 7 P09601 1 +Positive regulation of chemokine production 0.578647148265093 0.9365506732332648 0.3489897352351725 1.0 0.6147467895079722 7 P09601 1 +Innate immune response activating signal transduction 0.5558574952221401 0.9361512358510612 0.3491953263062455 1.0 0.6147639536036481 3 Q13153 1 +Response to lectin 0.5558574952221401 0.9361512358510612 0.3491953263062455 1.0 0.6147639536036481 3 Q13153 1 +Meiotic cell cycle checkpoint signaling 0.5556103376177264 0.9350055834432284 0.3497854219916831 1.0 0.6148105392137867 3 O60921 1 +Electron transport chain 0.3287754043153468 0.93377935330393 0.3504177218945115 1.0 0.6148105392137867 65 P13073,O95168,P43304,P21912,O14949,O75306,P16435,Q9H3K2,O96000,Q9Y6M9,P04062,O43676,Q9UDW1 13 +Negative regulation of protein catabolic process 0.357056839408288 0.9336018631134296 0.350509303909901 1.0 0.6148105392137867 36 Q16850 1 +Glycoprotein metabolic process 0.3432379536926265 0.9308407957116132 0.3519359233918844 1.0 0.6161332200374373 45 Q9HC07,Q9BT22,O60502,Q8NCH0,Q7LGA3,Q96L58,O15118,Q9H4A6,P46977,O14734 10 +Folic acid metabolic process 0.5756367983330172 0.9226067873018612 0.3562121573261552 1.0 0.6201608218784255 7 P41440,Q9H2D1 2 +Peripheral nervous system development 0.5590272466773024 0.9220728287194496 0.3564905886844822 1.0 0.6204735003496478 8 P31751,Q9NR77 2 +Viral protein processing 0.5908864663555045 0.9186361339661732 0.3582859253619146 1.0 0.6225627011962634 6 P48729,P49840 2 +Hindbrain development 0.3784575352951562 0.9163883536730556 0.3594632415699768 1.0 0.6237452268038458 29 O14949,Q9BRK5,Q14103,P54802,P04062 5 +Positive regulation of glucose transmembrane transport 0.6177395653150034 0.9156269982973042 0.3598625658610306 1.0 0.6237485335382523 5 P31751 1 +Positive regulation of glucose import 0.6177395653150034 0.9156269982973042 0.3598625658610306 1.0 0.6237485335382523 5 P31751 1 +Regulation of nervous system process 0.5053995820716742 0.9109798127502532 0.3623060103520605 1.0 0.6269996360967302 11 Q9UQB8,P04062,P05067 3 +Peptidyl lysine acetylation 0.3706789322030237 0.9109230433753795 0.3623359232393555 1.0 0.6269996360967302 31 P46379,Q13363,O75844,P16435 4 +Neutral lipid metabolic process 0.4592349768311211 0.910726747184438 0.3624393674406057 1.0 0.6269996360967302 13 Q8WTV0,Q8NCC3,Q9HCL2,Q96N66 4 +Neuron development 0.2936934396503225 0.910130235238914 0.3627538309032487 1.0 0.6269996360967302 146 O00264,Q32P28,P50897,P41440,Q9NR77,Q9NQC3,Q96G23,Q14108,Q99707,O14949,P42892,P54802,P05067,Q9NUL3,O75503,P08670,O95487,P04062,Q05086,Q13555,P61006,Q9UQB8,Q9NZJ7,Q8N0X7,Q8WWV3 25 +Macrophage apoptotic process 0.4871888726207906 0.9099728287471832 0.3628368394296624 1.0 0.6269996360967302 2 Q96EB6 1 +Regulation of macrophage apoptotic process 0.4871888726207906 0.9099728287471832 0.3628368394296624 1.0 0.6269996360967302 2 Q96EB6 1 +Monocarboxylic acid catabolic process 0.3447093343765706 0.9078783020228582 0.3639425225965187 1.0 0.6285642797416628 43 Q8NCC3,Q15067,O15254,A1L0T0,P23786,Q16836,Q13011,Q9BWD1,P40939,P16930,P31751 11 +Embryonic hemopoiesis 0.5496155254485535 0.9072665937116536 0.3642658354120702 1.0 0.6287599592039177 3 Q9H6E4,Q15648 2 +Digestion 0.504496796603429 0.9060456718517196 0.3649116790578111 1.0 0.6287599592039177 11 Q8WTV0 1 +Negative regulation of neuron apoptotic process 0.388987378911685 0.9046564889831248 0.36564739885242 1.0 0.6296035024672224 25 P50897,O75312,P07196,O76024,P09601,Q01105,P04062,Q15233 8 +Regulation of intracellular transport 0.3018635319718004 0.9036395071960552 0.3661865852464561 1.0 0.63012220231929 96 Q00765,P55786,P61960,Q9HCU5,Q15154,Q9NR31,P36507,P60604,Q9Y282,Q9H6U6,O95487,O95429,Q6NUQ1,P27105,P31751,Q9BWF3,Q9ULX6,Q9P2W9,O75312,O95071,Q07666,P51572,P50402 23 +Regulation of mrna processing 0.308666635595851 0.9029712843321384 0.3665411354916934 1.0 0.63012220231929 83 P98175,P61978,O43865,Q15637,Q9UHX1,P84103,P14866,P09651,P62995,Q96EP5,P22626,P38159,Q9BWF3,O75525,Q13242,Q07666,Q15287,P98179,Q96ST2,Q8IY67,Q13595,P31483 22 +Negative regulation of calcium ion transmembrane transport 0.5708372014318566 0.900411311154033 0.367901403546198 1.0 0.6315791663831095 7 P21796 1 +Regulation of hormone secretion 0.4050701543351713 0.8978238581566106 0.3692794630756788 1.0 0.6325767258527429 20 P00367,P22059,P40939,P51809,Q16836 5 +Regulation of protein targeting 0.4111851554078963 0.8949505020673226 0.3708135483748371 1.0 0.6343258075629895 18 P31751,P55786 2 +Cellular response to hyperoxia 0.4835285505124453 0.891100157932031 0.3728754402190808 1.0 0.6358267352444166 2 O95352 1 +Regulation of neurotransmitter levels 0.3817010688844318 0.8899980050463702 0.3734669572752307 1.0 0.6364347333805371 27 P50897,P21964,Q8NCG7,O14936,P16615 5 +Deoxyribose phosphate catabolic process 0.568315717458016 0.8887700897932644 0.3741266536800673 1.0 0.6367301832948741 7 P00813,Q9H773 2 +Regulation of protein localization 0.2858845097231415 0.8884919567182986 0.3742761805016046 1.0 0.6367766561488005 183 O00264,Q8NEB9,Q32P28,Q16850,Q96FF9,P14373,P25054,P55786,P61960,Q9NQC3,O60488,Q15154,P00367,Q10713,P60604,Q9Y282,Q9H6U6,P62942,P22059,O95429,Q9H4A6,P40939,P31751,P61006,O75312,Q16836,P51572,P50402,Q9UEU0 29 +Mast cell activation 0.6110057961744269 0.887306478178275 0.3749139187486583 1.0 0.6371862161646339 5 P09601 1 +Mast cell activation involved in immune response 0.6110057961744269 0.887306478178275 0.3749139187486583 1.0 0.6371862161646339 5 P09601 1 +Gmp salvage 0.6083549761358367 0.887153159557365 0.3749964468218878 1.0 0.6371862161646339 4 P55263 1 +Negative regulation of cell projection organization 0.3868356328799086 0.8871012674300464 0.3750243817662189 1.0 0.6371862161646339 25 Q9NQC3,Q96G23,Q9NR77,Q05086,P08670 5 +Protein k48 linked ubiquitination 0.5347058892403262 0.8846357095258851 0.376353140489357 1.0 0.6387523698275706 9 Q05086,P60604,Q96J02 3 +Chloride transport 0.5510291490383437 0.883617946204306 0.3769024879785325 1.0 0.6388703296818717 8 Q9UHG3,P08183,Q96S66,P51790 4 +Regulation of dna topoisomerase atp hydrolyzing activity 0.5441230318564629 0.8819406425977049 0.3778089070651602 1.0 0.6388703296818717 3 Q08211,Q00839 2 +Regulation of isomerase activity 0.5441230318564629 0.8819406425977049 0.3778089070651602 1.0 0.6388703296818717 3 Q08211,Q00839 2 +Response to salt 0.6066634042475154 0.8800977377896082 0.3788063645386457 1.0 0.6398978652164108 4 P07196,Q14103 2 +Multi multicellular organism process 0.3883262518193919 0.8794415533773949 0.3791619100260135 1.0 0.6400587445935232 24 P11166,Q96GC9,Q9BQE5,Q9UIQ6,P41440 5 +Mitochondrial electron transport nadh to ubiquinone 0.3947618371716452 0.8774031155067205 0.3802677215473169 1.0 0.6414080483272583 22 O96000,O75306,O43676,O95168 4 +Urogenital system development 0.3510815215267258 0.8755656340186073 0.3812662147463883 1.0 0.641885035177749 36 O95470,O75844,Q9NZJ7,P46379,P07602,Q05086 6 +Intestinal epithelial cell differentiation 0.5420724832256805 0.8725091543092383 0.3829306763404643 1.0 0.6436516160817763 3 P04818 1 +Negative regulation of b cell proliferation 0.4798682284041112 0.8722816173481314 0.3830547635329653 1.0 0.6436878494271832 2 P42574 1 +Positive regulation of calcineurin mediated signaling 0.479136163982431 0.8685247472478247 0.3851071307060292 1.0 0.645834523594731 2 P26599 1 +Glycosylation 0.3512752207730516 0.8680380857418769 0.3853734833493556 1.0 0.6458555067985197 35 Q9HC07,Q9BT22,O60502,Q96L58,O15118,P46977,P04062,O75503 8 +Positive regulation of translation 0.3344310710295837 0.864326125847568 0.387408762113427 1.0 0.6478828472424334 54 Q9Y2R0,O60506,Q07666,P60228,P98179,P14618,P08670,Q567V2 8 +Histone h3 k36 demethylation 0.5400549487361809 0.8632427675725189 0.3880040040025443 1.0 0.6481876362767358 3 Q8IUF8 1 +Response to interferon beta 0.6032494819960748 0.8548086014981883 0.3926571155853626 1.0 0.6526831040545694 5 P60604 1 +Cellular response to interferon beta 0.6032494819960748 0.8548086014981883 0.3926571155853626 1.0 0.6526831040545694 5 P60604 1 +Leukocyte mediated cytotoxicity 0.450012553876621 0.8547848071577644 0.3926702905406354 1.0 0.6526831040545694 13 P01889,P53634,P51809 3 +Pore complex assembly 0.4723291057371813 0.8535833370144682 0.3933358943561496 1.0 0.6536163961799648 12 Q9NQC3,Q9BTX1 2 +Protein insertion into mitochondrial inner membrane 0.6020007992263899 0.8495902758083403 0.3955529201755912 1.0 0.6553922493698499 5 Q9P0J0,P62072 2 +Glycerophospholipid metabolic process 0.3390583521354235 0.8489002102457361 0.3959368218685015 1.0 0.6554418864129171 43 Q8WTV0,Q8NEB9,P35790,Q9HCL2,Q96N66,P40939,Q8NCC3,Q8TBX8,Q9BXW7,P48651,Q10713,Q9NPH0,Q9NTJ5,Q92643 14 +Negative regulation of peptidyl lysine acetylation 0.5592183961499946 0.8468932764039606 0.3970546104605081 1.0 0.6568402752229434 7 Q13363 1 +Negative regulation of leukocyte mediated immunity 0.59798858457139 0.8440274147114156 0.3986540863748202 1.0 0.6584452392162908 4 P09601 1 +Membrane fusion 0.3467428957623546 0.8435464737930667 0.3989228856393767 1.0 0.6587159063766458 37 O15400,P61006,Q9P2W9,Q86Y82,Q9BZG1,P31751,P51809,Q8IWA4,Q13190,Q9H267,Q9UEU0 11 +Intrinsic apoptotic signaling pathway in response to dna damage 0.3903436559346949 0.8432326922293021 0.3990983178561049 1.0 0.6588323006838356 22 P23396,P46379,Q96K76,P09601,P61978,P13693 6 +Myeloid leukocyte activation 0.4269853354704848 0.8409218406517222 0.4003917220159092 1.0 0.6607936989526493 15 P05067,P51809,P09601 3 +Nuclear transcribed mrna catabolic process deadenylation dependent decay 0.3868010547408228 0.8399938373884697 0.4009118418298449 1.0 0.6613043991087143 23 Q969T7,O60506,O95453,Q14103,P67809,Q9NPI6 6 +Regulation of ion transport 0.3141598719389301 0.8375397157300651 0.4022892624589207 1.0 0.6614304409397717 70 O14936,Q96GC9,P14373,P21796,O75844,P62942,O76024,P05067,O43865,P51809,P08183,Q13546 12 +Regulation of peptide transport 0.4057977875295481 0.8372300843177228 0.4024632501417533 1.0 0.6614304409397717 17 P22059,P00367,P40939,Q16836 4 +Negative regulation of histone acetylation 0.5989571922267536 0.8368875750388127 0.4026557650608959 1.0 0.6615736438242096 5 Q13363 1 +Negative regulation of response to external stimulus 0.3394377475851637 0.8362490024183908 0.4030148362963976 1.0 0.6618198957567746 42 Q96G23,P80303,P28070,P01889,O14936,P04062,O43657 7 +Glycerolipid metabolic process 0.33104325501507 0.8292559917010501 0.4069595676080844 1.0 0.6639809909638377 50 Q8WTV0,Q8NEB9,P35790,Q9HCL2,Q96N66,P40939,Q8NCC3,Q8TBX8,Q9BXW7,P48651,Q8NCG7,Q10713,Q9NPH0,Q9NTJ5,Q92643 15 +Negative regulation of adenylate cyclase activity 0.4714494875549062 0.8292259535923885 0.4069765615210015 1.0 0.6639809909638377 2 P04899 1 +Negative regulation of lyase activity 0.4714494875549062 0.8292259535923885 0.4069765615210015 1.0 0.6639809909638377 2 P04899 1 +Positive regulation of hormone secretion 0.5067142340699949 0.82683669932527 0.4083296258978981 1.0 0.6658424393212999 10 P22059,P00367,P51809 3 +Cellular metabolic compound salvage 0.5229629152027435 0.8260711431540467 0.4087637359978837 1.0 0.6662042405489912 9 P55263 1 +Proteolysis 0.2850066800495774 0.8212906026872306 0.4114807591712657 1.0 0.6687439147672225 342 P09960,P36551,Q8NEB9,Q15005,Q9UBU6,P46379,Q7L5N1,P67812,Q7Z2K6,Q9Y679,P55786,Q969V3,Q9BUN8,Q96A33,O14773,Q15392,Q8TCT9,P23396,P48729,Q92896,O43242,Q9UIQ6,P16435,Q99436,O76024,P42892,Q10713,P05067,P53582,Q86TI2,P60604,O75503,Q9Y5A7,P53634,P49721,Q99797,O95260,Q9P0J0,P38159,Q9NXV2,O43847,Q96K76,P28070,Q9UJX4,Q96A26,Q96J02,P04062,Q05086,Q92643,Q5JVF3,P42785,O75976,P20618,O75844,Q5JRX3,Q9NZJ7,Q92905,P28072,P48556,Q9UHG3,P51572 61 +Organonitrogen compound catabolic process 0.2836238252295941 0.8187778008731731 0.4129131986303662 1.0 0.6701335698033367 331 P09960,Q6YP21,Q16850,P50897,Q9UBU6,P25054,P46379,Q9H773,P08236,P55786,Q13546,Q8WTV0,Q96A33,Q9BUN8,O95470,Q8TCT9,P21964,Q9UIQ6,Q99436,P00367,O76024,P42892,P09601,P30043,P54802,Q8N511,Q13190,P60604,O75503,P53634,O60502,P49721,O95260,Q9NXV2,O43847,Q96K76,P28070,Q9UJX4,P30519,Q9NUJ1,P04062,P16930,Q05086,Q13126,Q8NCC3,O75844,P28072,Q9UHG3,P51572 49 +Cellular response to arsenic containing substance 0.5530546808674772 0.8186444598638035 0.4129892930183354 1.0 0.6701335698033367 7 P09651,P09601,O00571 3 +Macrophage differentiation 0.5527163798082481 0.8170971932374264 0.413872886819588 1.0 0.6705274796008706 7 P05067,P04062 2 +Xenobiotic metabolic process 0.5209912140770565 0.8162755369285443 0.4143425625495969 1.0 0.670847694718067 9 P07099,O43169 2 +Flavin containing compound metabolic process 0.46888726207906 0.8161906467955431 0.4143911054661777 1.0 0.670847694718067 2 Q8NFF5 1 +Voluntary musculoskeletal movement 0.529476382277554 0.8148901121841586 0.4151352135266859 1.0 0.6718790591700269 3 P18887,P42345 2 +Positive regulation of stress activated protein kinase signaling cascade 0.5201360671848306 0.8120308156215894 0.4167739495159137 1.0 0.6734652861426728 9 P05067,Q13546 2 +Negative regulation of cell morphogenesis involved in differentiation 0.528377883559136 0.8098933421015886 0.4180014787163639 1.0 0.6749207303258565 3 Q9P258,O43707 2 +Toxin transport 0.4643343887322646 0.8078336279061253 0.4191863637485915 1.0 0.6761695764680518 12 Q93050 1 +Regulation of insulin secretion 0.4303243258593338 0.8017125488264729 0.4227192551749115 1.0 0.6780356371967539 14 P22059,P00367,P40939,Q16836 4 +Positive regulation of stem cell proliferation 0.5869930794922098 0.7986083945377229 0.4245175185727294 1.0 0.6802248549258794 4 Q96AC1,O95251 2 +Arf protein signal transduction 0.5258147198828269 0.7982533370375895 0.4247234910326809 1.0 0.680381239271031 3 Q92538,Q15555 2 +Mechanosensory behavior 0.4652269399707292 0.7976291934379248 0.425085704591597 1.0 0.6806141426743295 2 P42858 1 +Stress activated protein kinase signaling cascade 0.350895638675911 0.7961227217135166 0.4259607086777999 1.0 0.6816674303031425 33 Q99956,O75844,Q969S3,Q96J02,P36507,P05067,Q9P035,Q13546 8 +Learning 0.4101392439063105 0.795270068979525 0.4264564204298211 1.0 0.6822868010852235 16 P05067,O00264,P50897,Q05086 4 +Chondrocyte differentiation 0.547370239038202 0.7926932636445677 0.4279565560107299 1.0 0.6839896279621595 7 P16435 1 +Axonal transport of mitochondrion 0.5875024377791531 0.7893115859513656 0.4299299166473656 1.0 0.6855727753904396 5 O60313 1 +Regulation of endoplasmic reticulum tubular network organization 0.5872410722350161 0.7882306282470835 0.4305618167964202 1.0 0.6862318065112786 5 P57088 1 +Nuclear pore complex assembly 0.5149645285188815 0.786411522938815 0.4316264349017005 1.0 0.6872307274443001 9 Q9NQC3,Q9BTX1,P57740,Q8N1F7 4 +Glial cell development 0.397940848312018 0.782144897276606 0.4341294235363997 1.0 0.6901657434696169 17 Q13144,P49770,Q9NR50,P05067,P31751,P08670 6 +Regulation of histone phosphorylation 0.5823636318158166 0.7795990437451975 0.435626918959106 1.0 0.6920206976784583 4 Q9ULX6 1 +Negative regulation of cell substrate adhesion 0.5286887799141451 0.777071973254208 0.4371163082792835 1.0 0.6933260387156894 8 O14936 1 +Cellular response to peptide hormone stimulus 0.3267255658826384 0.7770020728091381 0.4371575474024067 1.0 0.6933260387156894 54 P61006,Q8TBX8,Q9UQB8,P16435,P25054,P62993,Q9BSK2,P14618,O43865,P31751 10 +Regulation of myelination 0.528474369821206 0.7760569827296002 0.4377153414612276 1.0 0.6937583725558158 8 P53634 1 +Fatty acid beta oxidation 0.345031578012518 0.7737808479474483 0.4390604001297533 1.0 0.6948377091037538 34 Q15067,O15254,P23786,Q13011,Q9BWD1,P40939,Q16836,P31751 8 +Forebrain cell migration 0.4961756078087112 0.7723145351272992 0.4399281586623895 1.0 0.6952304645567404 10 Q9NQC3 1 +Hormone biosynthetic process 0.4958914249310967 0.7708497203229053 0.4407960124225099 1.0 0.6961804694310735 10 Q53GQ0,P16435,Q9UBM7 3 +Cellular response to reactive nitrogen species 0.5565619419601537 0.7672351062649623 0.4429417436584693 1.0 0.697909319081683 6 Q99707,Q14103 2 +Response to nitric oxide 0.5565619419601537 0.7672351062649623 0.4429417436584693 1.0 0.697909319081683 6 Q99707,Q14103 2 +Positive regulation of mitochondrion organization 0.3766587231020957 0.760333897176214 0.4470550248956595 1.0 0.702531025355432 23 P21796,P27544 2 +Positive regulation of cellular amide metabolic process 0.321890712797042 0.7587153060430637 0.4480228788186529 1.0 0.7034326798396668 58 Q9Y2R0,O60506,Q07666,P60228,P98179,P14618,P08670,Q567V2 8 +Inflammatory response 0.3168318407809713 0.7581019159505545 0.4483899728127123 1.0 0.7035721692872302 63 P42785,P53634,Q9BQE5,P51809,Q13151,Q8NCG7,P09601,P28070,Q8IV08,P05067,P04062,Q13546 12 +Protein polyubiquitination 0.3303040820074043 0.7577352643770093 0.4486094833761869 1.0 0.7037407138020243 43 P14373,Q9UIQ6,Q9UJX4,Q05086,P60604,P55786 6 +Regulation of protein tyrosine phosphatase activity 0.456808199121522 0.7552305516341884 0.4501106602678701 1.0 0.7045841756554965 2 P04899 1 +Positive regulation of dendritic cell differentiation 0.4568081991215208 0.7552305516341833 0.4501106602678733 1.0 0.7045841756554965 2 P09429 1 +Vesicle organization 0.2973393582800592 0.7547314988169623 0.4504101027656193 1.0 0.7045841756554965 85 Q99523,Q8NEB9,P61006,Q14108,Q9HCU5,O95487,O15027,Q9BZG1,P31751,P22059,Q9NR31,Q9H4A6,P51790,P51809,Q13190,Q9H267,Q9UEU0 17 +Regulation of t cell receptor signaling pathway 0.5790955356485096 0.7546553660495322 0.450455793992834 1.0 0.7045841756554965 5 P23396 1 +Regulation of antigen receptor mediated signaling pathway 0.5790955356485096 0.7546553660495322 0.450455793992834 1.0 0.7045841756554965 5 P23396 1 +Response to lead ion 0.5761397836818163 0.7541601716308212 0.450753049942967 1.0 0.7047807353212369 4 P05067 1 +Neurotransmitter metabolic process 0.5760317254872817 0.7537197522839749 0.4510175187320902 1.0 0.7048762714961568 4 P21964 1 +Long term synaptic potentiation 0.5080745471410721 0.7524269321350605 0.4517943554320873 1.0 0.7052756631627848 9 Q14168 1 +Regulation of calcium ion transport 0.3595117601708071 0.7520742399786404 0.452006414269539 1.0 0.7052756631627848 29 Q96GC9,P14373,P21796,P62942,O76024,O14936 6 +Regulation of defense response to virus 0.4223718659960593 0.7519907306111105 0.4520566331484192 1.0 0.7052756631627848 14 O75844,O43657 2 +Regulation of transmembrane transport 0.3173597075677967 0.7513662622991623 0.4524322610184996 1.0 0.7056043787995026 62 O75298,Q96GC9,P21796,Q16625,P50570,O75844,P27105,P62942,P05067,O43865,O75323,P31751,P08183,Q13546 14 +Regulation of mitochondrial fusion 0.5772687460109788 0.7471570559121216 0.4549687629257462 1.0 0.7087577899870556 5 Q8N2A8,Q99536 2 +Icosanoid metabolic process 0.381262909411069 0.7457164778020631 0.4558387031164157 1.0 0.7097702967079312 21 P09960,Q15067,Q8N4Q0,P07099,Q9H7Z7 5 +Response to nerve growth factor 0.5367756263649125 0.7446205334916843 0.4565011512253882 1.0 0.7103143415613565 7 P05067,Q05086 2 +Regulation of cellular respiration 0.4210118306762156 0.7435142229222256 0.4571704137789041 1.0 0.7109526523913698 14 P14406,Q9NZ45 2 +Phenol containing compound metabolic process 0.4744750240480648 0.7432172462931304 0.4573501635609047 1.0 0.71105604924105 11 P16930 1 +Dicarboxylic acid catabolic process 0.5498646686149058 0.7381226349865588 0.4604399301583972 1.0 0.7130382966419915 6 P00367 1 +Positive regulation of cell cell adhesion 0.3635640801039521 0.7379156585433602 0.4605657030083532 1.0 0.7130533868030681 27 Q9HCL2,P23396,P30825,P41440,P00813 5 +Regulation of myotube differentiation 0.5717886517378961 0.7364613238505318 0.4614499964813641 1.0 0.7140702681562741 4 Q9BYT8,P42345 2 +Cellular response to inorganic substance 0.3576533013078375 0.7360338528115363 0.4617100961580065 1.0 0.7141448456663018 29 P05067,Q99707,P09601,Q14168 4 +Regulation of vitamin d receptor signaling pathway 0.5109945379542584 0.7315277809588048 0.464456842055847 1.0 0.7169560005966579 3 O15164 1 +Vitamin d receptor signaling pathway 0.5109945379542584 0.7315277809588048 0.464456842055847 1.0 0.7169560005966579 3 O15164 1 +Negative regulation of activated t cell proliferation 0.5104357378249725 0.7290328543660118 0.4659815656778718 1.0 0.7177213614636112 3 P42574,Q14160 2 +Cellular response to vitamin d 0.5726306343526083 0.7281748326624045 0.4665065698698711 1.0 0.7182794195893454 5 O15164,Q8TB36 2 +Branching involved in mammary gland duct morphogenesis 0.4509516837481663 0.7260006692251656 0.4678383602929796 1.0 0.7189936905555265 2 Q15648 1 +Development of secondary female sexual characteristics 0.4509516837481663 0.7260006692251656 0.4678383602929796 1.0 0.7189936905555265 2 Q15648 1 +Development of secondary sexual characteristics 0.4509516837481663 0.7260006692251656 0.4678383602929796 1.0 0.7189936905555265 2 Q15648 1 +L aspartate transmembrane transport 0.56913218828108 0.7256924865622125 0.4680273088299616 1.0 0.719108038383382 4 Q9UJS0,Q9H936 2 +Response to progesterone 0.5688783416512679 0.7246649394874987 0.4686576090866157 1.0 0.7199002862358144 4 P04818,Q05086 2 +Retrograde transport vesicle recycling within golgi 0.4505856515373332 0.7241815752823337 0.4689542684429755 1.0 0.720070203988757 2 Q14746 1 +Negative regulation of inflammatory response 0.4702701195059277 0.7206713242607486 0.4711117594274383 1.0 0.7219037407091671 11 P04062,P28070 2 +Regulation of intracellular protein transport 0.3209538961793911 0.7198299916751161 0.4716296765188676 1.0 0.7223447448610517 55 Q9Y282,P61960,O75312,Q9H6U6,Q15154,Q9NR31,O95429,P51572,P27105,P31751,P60604,P50402,P55786 13 +T cell differentiation in thymus 0.5009162059133869 0.7173202617983468 0.4731765078601753 1.0 0.7239499530490308 9 P04062,O96005 2 +Cellular response to glucose starvation 0.484653388587395 0.7131886164086956 0.4757290494653499 1.0 0.7259666924023983 10 P11166,Q8NEB9 2 +Cerebral cortex cell migration 0.4990576156595733 0.7082420782345004 0.4787949396526221 1.0 0.7286968802761604 9 Q9NQC3 1 +Male meiosis i 0.4469253294289893 0.706043470103724 0.4801611047113165 1.0 0.7300681558192408 2 P54652 1 +Protein import 0.2952174178451797 0.7029571079649709 0.4820824799788261 1.0 0.7322499333796737 80 Q99595,P61960,O75312,O60830,O95071,O14925,O96008,Q9NS69,P02545,Q8TEX9,P40855,Q96P70,P50542,O43615,O75381,Q99567,Q8N1F7 17 +Detection of visible light 0.4461932650073201 0.7024276483766463 0.4824125078780392 1.0 0.7322499333796737 2 Q15555 1 +Phototransduction visible light 0.4461932650073201 0.7024276483766463 0.4824125078780392 1.0 0.7322499333796737 2 Q15555 1 +Regulation of cell activation 0.3169589436032524 0.7013598612555235 0.4830784647266655 1.0 0.7329063802692136 58 P49366,P53634,Q9HCL2,Q9BWH2,P23396,P51809,P30825,P09601,Q96J02,P00813,O96005 11 +Activation of innate immune response 0.3812868682577661 0.7004392852496336 0.4836530095357916 1.0 0.733600771651534 19 P23246,Q13177,P43243,Q9NUD5,Q15233,Q8WXF1,Q13153,Q96PK6 8 +Positive regulation of intracellular protein transport 0.326149340158546 0.6996375068868556 0.4841537129658038 1.0 0.7341828526568397 42 Q9Y282,O75312,Q9H6U6,Q15154,Q9NR31,P51572,P27105,P31751,P50402,P55786 10 +Negative regulation of t cell proliferation 0.5405952171354986 0.6981262660465233 0.4850982330905178 1.0 0.7347670112378407 6 Q96J02,Q9Y6D9 2 +Sterol transport 0.3681712142266942 0.6940363814514936 0.4876593934897393 1.0 0.7375196468271037 23 Q8WTV0,O15118,Q9BZF3 3 +Regulation of mitochondrion organization 0.3269016744871327 0.6935528328181496 0.487962682160187 1.0 0.7375196468271037 41 O00429,P27544,P49840,Q99536,P21796,P02545,Q9H3K2,Q9H4A6,Q96A26,O60313,Q8N2A8 11 +Positive regulation of receptor mediated endocytosis 0.5252213892538209 0.6927023479771238 0.4884963652998804 1.0 0.7379163092763833 7 P61978,P50897,Q8NBU5 3 +Primary alcohol catabolic process 0.4439970717423121 0.6916045448604466 0.4891857067485585 1.0 0.7384245893165305 2 P30837 1 +Ethanol catabolic process 0.4439970717423121 0.6916045448604466 0.4891857067485585 1.0 0.7384245893165305 2 P30837 1 +Positive regulation of mitochondrial calcium ion concentration 0.5246897744054552 0.6903278908967275 0.4899880121202566 1.0 0.7390684113869918 7 P51572,Q96AQ8 2 +Icosanoid biosynthetic process 0.4434962963733896 0.6897277900468903 0.4903653862769408 1.0 0.7393164973695088 12 P09960,Q9H7Z7 2 +Regulation of protein targeting to membrane 0.5243034351913067 0.6886031466299896 0.4910730403662993 1.0 0.7398924025715173 7 P31751 1 +Regulation of cyclin dependent protein kinase activity 0.3942165772466042 0.6885588399565968 0.4911009304739586 1.0 0.7398924025715173 16 Q99640,P14635,P25054,Q16543,O00410 5 +Regulation of ion transmembrane transport 0.3182119776598898 0.6874452190951984 0.4918022104808703 1.0 0.7406546760299678 50 Q96GC9,P21796,P50570,O75844,P62942,P05067,O43865,O75323,P08183,Q13546 10 +Intracellular sterol transport 0.5222357117901675 0.6793843375724318 0.4968943712111033 1.0 0.7466497995364545 7 O15118 1 +Positive regulation of inclusion body assembly 0.4414348462664704 0.6790250032527133 0.4971220196171857 1.0 0.7468131225548438 2 P62195 1 +Protein peptidyl prolyl isomerization 0.3721341418626606 0.6772760302161651 0.4982308361903325 1.0 0.7482998061250975 21 P62942,Q9Y680,Q9NWM8 3 +Fatty acid catabolic process 0.3264199999415382 0.6761754714143737 0.4989292439258479 1.0 0.7491463087213566 40 Q8NCC3,Q15067,O15254,A1L0T0,P23786,Q13011,Q9BWD1,P40939,Q16836,P31751 10 +Binding of sperm to zona pellucida 0.4615631039678999 0.6742593953973162 0.5001464140896381 1.0 0.7497419263741042 11 P45880 1 +Sperm egg recognition 0.4615631039678999 0.6742593953973162 0.5001464140896381 1.0 0.7497419263741042 11 P45880 1 +Regulation of synapse structure or activity 0.3551838292351487 0.6681860180195502 0.5040148593976144 1.0 0.7531935604677154 27 O00264,P50897,Q9UQB8,P05067,Q05086 5 +Neuromuscular process 0.3647251150633683 0.6672442602231308 0.5046161239342952 1.0 0.7533840727846624 23 O14773,O75844,P07196,Q8N0X7,P05067,P04062 6 +Cell cell recognition 0.4183433602337386 0.6649248069839 0.5060985881367444 1.0 0.7545886621475887 13 P45880 1 +Negative regulation of leukocyte apoptotic process 0.5539265553924544 0.6646401039821241 0.5062807120553385 1.0 0.7545886621475887 4 Q9HCL2 1 +Negative regulation of lymphocyte apoptotic process 0.5539265553924544 0.6646401039821241 0.5062807120553385 1.0 0.7545886621475887 4 Q9HCL2 1 +Progesterone receptor signaling pathway 0.5539165416004396 0.6646002524738175 0.5063062077323999 1.0 0.7545886621475887 4 O95071,Q05086 2 +Protein localization to lysosome 0.4082556174058716 0.6644778473283177 0.506384522718667 1.0 0.7545886621475887 14 Q9NQC3 1 +Regulation of neurotransmitter transport 0.4181672911120825 0.6638831807519197 0.5067650818746072 1.0 0.7549765505478843 13 O14936,P16615 2 +Cellular macromolecule localization 0.2838318651943128 0.6594991993382122 0.5095752600578518 1.0 0.7565567265068133 473 Q99595,Q8NEB9,O60830,O60725,Q9H9C1,Q9NS69,P46379,P55786,Q9NQC3,Q14108,P43307,Q9HD45,P60604,Q9Y282,Q15070,Q9HD20,Q8N4H5,P31751,Q9P2W9,Q14168,P62072,O75381,P24390,Q96FF9,O15118,O43865,Q9BUN8,Q96A33,Q99729,Q8TCT9,Q15629,Q8TEX9,O14936,Q13190,O95429,Q9Y5M8,Q4VCS5,P61006,Q5JRX3,A0AVF1,O43681,P51572,Q9H267,Q9UEU0,O00264,P25054,P41440,P35606,Q96P70,Q9UK61,Q10713,Q8WWC4,Q99442,Q8TD16,Q8NBU5,Q9H6U6,O95487,Q9H4A6,O43615,Q8N1F7,Q99523,O75312,O14925,O96008,O15027,Q9BZG1,P50402,P31483,Q15005,Q8TB36,P67809,Q9Y679,Q9NPI6,P61960,O14773,Q9HCU5,Q15154,Q9NR31,Q969Q5,O75298,O15400,Q99797,Q16625,Q9P0J0,P57105,P50542,P27105 87 +Protein acetylation 0.3257390467380701 0.6581267292624363 0.5104567016256509 1.0 0.7575998044458242 39 Q9NRF9,O95251,O75844,P41227,O95619,O14929,P16435,O00571,P46379,Q13363,Q01105,Q96ST2 12 +Myeloid leukocyte differentiation 0.3539113540392512 0.6576415310596404 0.5107685011248457 1.0 0.7578833963748006 27 P05067,P04062,O00625,Q14739 4 +Organ growth 0.3689569823822413 0.6535817117647343 0.5133813298069247 1.0 0.760061459467355 21 O75844,Q9NZJ7,P07602,P16435 4 +Positive regulation of small molecule metabolic process 0.4164142803997227 0.6535231106008205 0.5134190953764564 1.0 0.760061459467355 13 P31751,P16435 2 +Signal release 0.3187517486705263 0.6534797173859395 0.5134470611024295 1.0 0.760061459467355 44 P50897,P00367,P22059,P40939,O14936,P51809,Q16836,P16615 8 +Negative regulation of fat cell differentiation 0.5540094370053138 0.6528610087316655 0.5138458879540622 1.0 0.7602178988811239 5 Q8N4Q0 1 +Regulation of response to osmotic stress 0.5539718215089889 0.6527104725627255 0.5139429497081209 1.0 0.7602178988811239 5 P08183 1 +Cellular response to acid chemical 0.4726476747334593 0.6522520483359812 0.514238588307222 1.0 0.7603367539785069 10 Q9UQB8,Q99729 2 +Glutamine family amino acid catabolic process 0.515227639618687 0.6482990019776315 0.5167915794116555 1.0 0.7628538762159355 7 P00367 1 +Ventricular cardiac muscle tissue development 0.5150975345785193 0.6477243348113484 0.517163261954372 1.0 0.763043703536909 7 P62942 1 +Positive regulation of phospholipid biosynthetic process 0.4348462664714467 0.6469248925101834 0.5176805544215921 1.0 0.763627471959294 2 O95573 1 +Respiratory system development 0.3709929597452698 0.6462509316742956 0.5181168599165691 1.0 0.7640915307860513 20 P09960 1 +Negative regulation of ion transport 0.3967540018841427 0.64586161677422 0.5183689793246429 1.0 0.764272362352853 15 P21796,P62942 2 +Tetrapyrrole biosynthetic process 0.4149111807102514 0.6446559303488242 0.5191501811229213 1.0 0.7645779566789591 13 P36551,O00264,O75027,Q7KZN9 4 +Endosome to lysosome transport 0.3781426579348556 0.6446262757835052 0.5191694028961473 1.0 0.7645779566789591 17 Q9H9C1,P51809,Q9H267 3 +Protein autoubiquitination 0.4859304260537607 0.6446139107933118 0.5191774178595736 1.0 0.7645779566789591 9 Q05086 1 +Regulation of intrinsic apoptotic signaling pathway in response to dna damage 0.4706077095847606 0.6419768302077868 0.5208882270632476 1.0 0.766255978602732 10 P61978,Q96K76,P23396 3 +Response to cocaine 0.5512701729671612 0.6419169176206184 0.5209271291297324 1.0 0.766255978602732 5 Q05086 1 +Neuron projection guidance 0.3958941545062873 0.6403881530757871 0.5219202828980785 1.0 0.7667804463384317 15 P05067,P42892 2 +Positive regulation of mitochondrial translation 0.5266328500425118 0.6386297221347951 0.5230638410999451 1.0 0.7676391971383235 6 Q9Y2R0 1 +Receptor diffusion trapping 0.4326500732064526 0.6363081918706387 0.5245755666448115 1.0 0.7684004156208804 2 Q9NQX3 1 +Neurotransmitter gated ion channel clustering 0.4326500732064526 0.6363081918706387 0.5245755666448115 1.0 0.7684004156208804 2 Q9NQX3 1 +Positive regulation of receptor clustering 0.4326500732064409 0.6363081918705827 0.524575566644848 1.0 0.7684004156208804 2 Q14696 1 +Membrane docking 0.3513296892012769 0.6362889370731993 0.524588114264271 1.0 0.7684004156208804 27 Q7Z6M1,P61006,O43865,Q13190,P16615,Q9UEU0 6 +Jnk cascade 0.3861687153284283 0.6351746933218814 0.5253144863148669 1.0 0.7689261704557553 16 Q99956,Q969S3,Q96J02,P05067,Q9P035,Q13546 6 +Head development 0.2799889633731671 0.6333915926475607 0.5264779538681075 1.0 0.7695868781061117 129 P50897,P07196,P46379,P11166,Q9NQC3,P61960,O95470,O14949,Q15154,Q14103,P00367,P48681,P54802,P05067,O75503,Q16352,Q96N66,O95487,Q9BRK5,P04062,Q05086,Q9UQB8,O15027,Q9BSJ2 24 +Response to testosterone 0.4979038675974768 0.6333557164588955 0.5265013764679436 1.0 0.7695868781061117 8 Q13126 1 +Negative regulation of cellular amide metabolic process 0.2901156293762909 0.6298593703256455 0.5287865975150849 1.0 0.7716695163179226 79 Q969T7,O60506,Q92600,P67809,Q92945,Q9NPI6,Q9NQC3,P23396,Q14103,P60228,Q10713,O95453,O75298,Q13526,P04818,O95197,O00571,Q9NQT5,Q9BWF3,Q14671,Q12906,P31483 22 +Intrinsic apoptotic signaling pathway by p53 class mediator 0.3846533418161191 0.6251743369921726 0.5318566431390452 1.0 0.7738236898955042 16 P46379 1 +Negative regulation of calcium ion transport 0.481877487699924 0.6251614202856857 0.5318651197672986 1.0 0.7738236898955042 9 P21796,P62942 2 +Negative regulation of tor signaling 0.4862687660197731 0.6228803747498102 0.533363135490144 1.0 0.7745671442533251 3 Q96EB6,P49840 2 +Gland development 0.3080530682309871 0.6177530130551866 0.5367381607558366 1.0 0.7776695530175727 60 Q9NQC3,O75844,Q9NZJ7,P09601,P07602,Q13505,P31751 7 +Reactive nitrogen species metabolic process 0.3920087367708332 0.6157228714477943 0.53807743953451 1.0 0.7785483806691056 15 P16435,O43169 2 +L ascorbic acid metabolic process 0.4846033038646453 0.6157056767066325 0.5380887900164462 1.0 0.7785483806691056 3 P11166 1 +Cellular response to thyroid hormone stimulus 0.4840717685829366 0.6134201028369666 0.5395985970924622 1.0 0.7794113163749042 3 Q15648,P48507 2 +Positive regulation of protein binding 0.3603226056879119 0.6132993856447994 0.539678399535156 1.0 0.7794113163749042 22 P05067,Q9BUN8,P62942 3 +Protein localization to organelle 0.2677922251447966 0.6110406325025637 0.5411726809143986 1.0 0.7799545662949023 284 Q99595,Q15005,Q8TB36,O60830,Q96FF9,P24390,Q9NS69,P25054,P46379,P67809,Q9Y679,Q96P70,P55786,Q9NPI6,P61960,Q9NQC3,Q96A33,Q14108,O14773,Q9UK61,Q15154,Q15629,Q8TEX9,Q10713,Q8WWC4,Q99442,Q8TD16,Q15070,Q99797,Q9P0J0,Q8N4H5,O95429,Q9H4A6,Q9Y5M8,P50542,O43615,Q8N1F7,Q99523,P61006,O75312,O95071,Q5JRX3,O14925,O96008,O15027,Q9H7B2,P52789,P51572,P62072,A0AVF1,O43681,O75381,P31483 53 +Positive regulation of leukocyte cell cell adhesion 0.3628758804959581 0.6084488051066654 0.5428898505001032 1.0 0.7817115783118459 21 P00813,Q9HCL2,P30825,P23396 4 +Regulation of organic acid transport 0.4636632353788852 0.6071905253461791 0.5437244792630374 1.0 0.7820165591783158 10 Q7L0J3,Q15041,P31751 3 +Primary alcohol metabolic process 0.390536407169185 0.6064066851213441 0.5442447303539917 1.0 0.7825254024823687 15 Q9BY49,P51648 2 +Positive regulation of immune system process 0.2788913302001026 0.6062819209684379 0.5443275617458592 1.0 0.7825254024823687 101 P46379,P01889,Q13546,P23246,P23396,P09601,P05067,P00813,Q13153,Q96PK6,P49366,P53634,Q9HCL2,O15400,P49770,P30825,Q96J02,Q07666,P43243,P51809,Q15233 21 +Hematopoietic stem cell proliferation 0.5418811756004492 0.6047016172918723 0.5453772733556839 1.0 0.783390544323359 5 P04062 1 +T cell mediated cytotoxicity 0.5183128022158914 0.6036675642290966 0.5460646830594418 1.0 0.783390544323359 6 P01889,P53634 2 +Organelle disassembly 0.3122435869837373 0.6015580139261665 0.5474683839481633 1.0 0.7838099234724217 45 O00429,P61960,P27544,Q07866,P49840,Q9BWH2,P21796,P04062,P06493,Q9Y6I9,Q16543,Q9Y3D6,P52789,P50851,P05141,Q13190 16 +Negative regulation of cyclin dependent protein serine threonine kinase activity 0.5177230438451308 0.6012046017759558 0.5477037198458645 1.0 0.7839680695832962 6 O00410,P25054 2 +Lens development in camera type eye 0.5405262569135139 0.5993709623491098 0.5489255362371492 1.0 0.7853588232672797 5 P08670 1 +Response to oxygen containing compound 0.2663149124590073 0.5982009460066028 0.5497058602987208 1.0 0.7857570425221743 237 P09960,Q8NEB9,P27544,Q8TB36,Q8TBX8,P25054,P62993,P07196,Q9BSK2,O43865,Q9HCD5,Q13546,Q8WTV0,P11166,Q99729,O43823,P23396,Q99707,P16435,Q14103,Q13151,Q86X55,P09601,P05067,Q86UE4,P62995,P08670,Q9HCL2,Q99720,P50570,P49770,Q9BRK5,Q15120,P22059,Q9H4A6,P40939,P04062,P31751,Q05086,Q13126,Q99523,P61006,Q9UQB8,P14618,O00767,Q16836 46 +Multicellular organism aging 0.4762109405924662 0.598134906662598 0.5497499204995255 1.0 0.7857570425221743 9 O75844 1 +Protein containing complex disassembly 0.2851257386086298 0.5980153766136346 0.5498296731124421 1.0 0.7857570425221743 88 Q8NEB9,O75844,Q9H9C1,P51809,Q01105,Q9H267,P04062,O75381,P16615,Q9UEU0 10 +Cellular response to vitamin 0.5165154376590073 0.5961679475626023 0.5510630357609911 1.0 0.7866243152586408 6 O15164,Q8TB36 2 +Regulation of cholesterol metabolic process 0.502595138475518 0.5929538011733646 0.55321207067907 1.0 0.7884945016828396 7 P16435 1 +Purine ribonucleotide salvage 0.5382417021998576 0.5904067258122955 0.5549180025073575 1.0 0.789373727927639 5 P55263 1 +Purine nucleotide salvage 0.5382417021998576 0.5904067258122955 0.5549180025073575 1.0 0.789373727927639 5 P55263 1 +Nucleotide salvage 0.5382417021998576 0.5904067258122955 0.5549180025073575 1.0 0.789373727927639 5 P55263 1 +Amp salvage 0.5382417021998576 0.5904067258122955 0.5549180025073575 1.0 0.789373727927639 5 P55263 1 +Cholesterol efflux 0.5019037699541518 0.589952700997146 0.5552223604495437 1.0 0.7895098479959762 7 Q8WTV0 1 +Myeloid cell activation involved in immune response 0.5014277260566466 0.5878880680006442 0.5566074259159106 1.0 0.7905840316516033 7 P09601 1 +Midbrain development 0.3653165252408104 0.5863695641416473 0.5576271927507697 1.0 0.7912482989256604 19 P00367,O14949 2 +Negative regulation of striated muscle cell differentiation 0.5339623773059421 0.586253348492791 0.5577052760028747 1.0 0.7912482989256604 4 P67809 1 +Leukocyte degranulation 0.4864501494717518 0.5811733180827177 0.5611236484957263 1.0 0.7947918252782648 8 P09601 1 +Negative regulation of cytokine production 0.3535535988861905 0.5810367291818728 0.5612156994996094 1.0 0.7947918252782648 23 O43823,P14373,P09601,Q96J02,P04062,P31483 6 +Microtubule anchoring at centrosome 0.5356169429672862 0.5801454487389599 0.5618165371393249 1.0 0.7954632882635727 5 Q86VS8,Q15154 2 +Purine nucleoside monophosphate metabolic process 0.3532493488488161 0.5787049473403363 0.5627882771940802 1.0 0.7964798927467168 23 O14936,Q00013,Q14168,P55263 4 +Golgi ribbon formation 0.5318654203555573 0.5781539093412523 0.5631602133098712 1.0 0.796644873897009 4 Q9H4A6 1 +Ovarian follicle development 0.5121335817364727 0.5779682783323353 0.5632855360351741 1.0 0.796644873897009 6 P49770,Q05086 2 +Ensheathment of neurons 0.355408711380079 0.5762665687578266 0.5644350160561178 1.0 0.797851546847802 22 P53634,O75312,Q13144,P17028,P49770,Q9NR77,P31751 7 +Vesicle cargo loading 0.4031050682688441 0.5755768054381469 0.5649012624623255 1.0 0.797851546847802 13 Q96PC5,O95487 2 +Negative regulation of release of cytochrome c from mitochondria 0.533976812900306 0.573754543914517 0.5661339127551854 1.0 0.7989890061626697 5 Q9H3K2,O60313 2 +Regulation of t cell mediated cytotoxicity 0.5306302737679707 0.5733961232711903 0.5663765145974022 1.0 0.7989890061626697 4 P01889 1 +Positive regulation of t cell mediated cytotoxicity 0.5306302737679707 0.5733961232711903 0.5663765145974022 1.0 0.7989890061626697 4 P01889 1 +Regulation of dephosphorylation 0.3295138922860921 0.572093279786638 0.5672587816614474 1.0 0.7997418888997454 32 P62942,O95429,Q86XL3 3 +Ectoderm development 0.4733510267423413 0.5677825417372884 0.5701826357640545 1.0 0.8027669647109918 3 P13693 1 +Regulation of histone h2b ubiquitination 0.4730867813987552 0.5666692545343878 0.5709389132581362 1.0 0.8027669647109918 3 Q6PD62,Q5VTR2 2 +Histone h4 acetylation 0.3664650495035942 0.5647961988538354 0.5722123927861782 1.0 0.8034778353638171 17 O95251,O75844,O95619,O14929,Q13363,Q96ST2 6 +Regulation of neuronal synaptic plasticity 0.4816174120166537 0.5594155453132766 0.5758781545398413 1.0 0.8062949519692578 8 P05067 1 +Glycosyl compound metabolic process 0.3419566197589498 0.5592952579210194 0.5759602311621408 1.0 0.8062949519692578 27 Q13126,O60725,P55263,P08236,Q9NUJ1 5 +Activation of immune response 0.309459326928612 0.5570216812618317 0.5775126158745936 1.0 0.8065904788566626 44 P23246,P23396,Q07666,P46379,P43243,Q15233,P00813,Q13153,Q96PK6 9 +Autophagy of mitochondrion 0.3365349425794214 0.5556072791900373 0.5784793541919973 1.0 0.8070429745816353 29 O00429,P27544,Q9BWH2,P49840,P21796,P04062,Q16543,Q9Y3D6,P52789,P50851,P05141 11 +Mucopolysaccharide metabolic process 0.4805615659586053 0.5546840780792214 0.5791107685775914 1.0 0.8074680994784422 8 Q8NCH0 1 +Negative regulation of intracellular protein transport 0.4805276674011417 0.5545323063313238 0.5792146023477898 1.0 0.8074680994784422 8 O95429,P60604 2 +Estrogen metabolic process 0.5290018295333625 0.5544714254115083 0.5792562561356593 1.0 0.8074680994784422 5 O95470 1 +Locomotory behavior 0.3389222843848506 0.5540171439488063 0.5795671129013755 1.0 0.8075401292943554 28 P50897,O75844,O15118,P54802,P05067,Q05086 6 +Stress granule disassembly 0.4690589527645552 0.5497726328030947 0.582475331692603 1.0 0.8099057438400559 3 P33176,Q07866 2 +Vesicle mediated transport 0.2694151553048228 0.5488175394068942 0.583130672362915 1.0 0.8102909165768881 310 Q8NEB9,P50897,P24390,P14373,Q9Y3E0,Q9H9C1,O15118,P62993,P41440,P35606,P51790,O95772,P61978,Q5VW38,P16615,Q9NX40,Q96PC5,Q8WTV0,Q14108,Q9HCU5,Q9NR31,Q13432,P09601,Q68EM7,O15127,P36507,P05067,O14936,Q13190,O75503,Q13153,Q9Y282,Q9ULJ7,Q8TD16,O15400,Q8NBU5,O95197,O95487,Q9BRK5,Q9H4A6,Q6NUQ1,O43760,P31751,Q05086,Q7Z6M1,Q99523,P61006,Q9P2W9,O15126,O15027,Q9BZG1,P51809,Q96RQ1,P51572,Q9H267,Q9UEU0 56 +Positive regulation of neural precursor cell proliferation 0.5273576874483996 0.5481335296311529 0.5836002192394936 1.0 0.810763924847431 5 P55209,P48681 2 +Regulation of aspartic type endopeptidase activity involved in amyloid precursor protein catabolic process 0.4679604540461368 0.5451886942983313 0.5856237464039242 1.0 0.8119594576543487 3 P49755,O75116 2 +Regulation of aspartic type peptidase activity 0.4679604540461368 0.5451886942983313 0.5856237464039242 1.0 0.8119594576543487 3 P49755,O75116 2 +Peptidyl arginine modification 0.4910965288870277 0.5434567746309421 0.5868153445278343 1.0 0.8130714484541478 7 Q6P2P2,Q7L592 2 +Positive regulation of insulin secretion 0.4909402455906059 0.5427904130050707 0.5872741147687115 1.0 0.8131687014816874 7 P22059,P00367 2 +Nucleobase transport 0.466746725774063 0.5401362659048317 0.5891030620151327 1.0 0.8142644260966542 3 Q9Y277 1 +Regulation of calcium ion transmembrane transport 0.3625045977416796 0.538011269129648 0.5905692686357387 1.0 0.8159317492286899 17 P21796 1 +Dendrite self avoidance 0.4110541727672059 0.534447160356774 0.5930321979357951 1.0 0.8178945823024871 2 P35613 1 +Regulation of circadian rhythm 0.3426834518492418 0.5316441592014362 0.5949724739914131 1.0 0.8194903887051538 25 P23246,Q14103,Q9BWF3,Q05086,Q15233 5 +Hormone transport 0.3405357793557705 0.5302039824510021 0.5959705101724495 1.0 0.8201453009343792 26 P00367,P22059,P40939,P51809,Q16836,Q13555 6 +Regulation of nucleobase containing compound transport 0.4139569055345432 0.5266830260938181 0.5984137248220653 1.0 0.82260594798181 12 Q9ULX6,Q07666,Q13546 3 +Multicellular organism growth 0.3486637644751412 0.5258421573108826 0.5989978808341276 1.0 0.8226854382590001 22 P05067,Q9HCL2,O75844 3 +Regulation of autophagy of mitochondrion in response to mitochondrial depolarization 0.4991656636451628 0.5248580108466403 0.5996819007229783 1.0 0.8230665527642915 6 P04062,P52789 2 +Regulation of cell projection organization 0.2722500938504787 0.5246915631472139 0.5997976232712063 1.0 0.8230665527642915 103 Q32P28,Q9Y277,P25054,P07196,Q9NR77,Q9NQC3,Q96G23,Q14108,Q86X55,Q9NUL3,Q13153,P08670,Q9H6U6,Q16625,Q05086,Q13555,Q9UQB8,Q8N0X7,Q8WWV3 19 +Iron ion transport 0.4850987674988065 0.5180148221086716 0.6044479278536934 1.0 0.82781420047183 7 P50570,O15173,O75027 3 +Regulation of dendrite extension 0.4073938506588561 0.517693258628411 0.6046723025072249 1.0 0.82781420047183 2 O60271 1 +Peptidyl glutamic acid modification 0.5189972974707966 0.516187366092076 0.6057235533191654 1.0 0.8290238647782255 5 P38435,Q8N0U8 2 +Epithelial cell proliferation 0.3127845842634116 0.514912345935935 0.6066142732411159 1.0 0.8296611958526133 37 Q8WTV0,Q9NQC3,P09601 3 +Skeletal muscle cell differentiation 0.4963643450822771 0.5135440593960887 0.6075707990804389 1.0 0.8296611958526133 6 Q92841,P17844,P50402 3 +Positive regulation of protein kinase b signaling 0.3831479067642709 0.5122917645259185 0.6084468281284638 1.0 0.8300367637962834 14 O95429,Q9NQC3 2 +Prostanoid metabolic process 0.3751106760998229 0.5099684399954785 0.6100735723995208 1.0 0.8308394755293415 15 Q8N4Q0,Q15067,Q9H7Z7 3 +Response to hydrogen peroxide 0.3442159005059343 0.5099393167711562 0.610093976137347 1.0 0.8308394755293415 23 P09601,Q05086,Q99720,Q13546 4 +Response to dexamethasone 0.4696394116721794 0.5062392733564051 0.61268868783585 1.0 0.8327472574655695 8 P16435 1 +Establishment of lymphocyte polarity 0.5124542124542141 0.5045753025222058 0.6138571600700848 1.0 0.833793866490695 4 Q96L92,Q14254,P35579 3 +Carnitine metabolic process 0.515636743148303 0.5034849789053704 0.6146233386275903 1.0 0.8345328341534652 5 P23786 1 +Positive regulation of proteolysis involved in cellular protein catabolic process 0.3107246421503422 0.5027565927390902 0.61513541548404 1.0 0.8348076390853445 38 P53634,P48729,P46379,P04062,P51572 5 +Cellular component disassembly 0.2706870179467709 0.5023151143168051 0.6154458790778992 1.0 0.835048460957651 144 Q8NEB9,P27544,Q9UEU0,P21796,O75844,Q9H9C1,P51809,Q9Y6I9,P25054,Q13190,Q01105,Q9H267,P04062,O75381,P16615,Q9ULX6 16 +Cellular response to molecule of bacterial origin 0.3387983415543406 0.5011737847606262 0.6162488222962756 1.0 0.8356506697700449 25 Q8WTV0,O43823,P08670 3 +Negative regulation of leukocyte proliferation 0.4807480748075051 0.4997350625646258 0.6172616403759084 1.0 0.8367887234463296 7 Q9Y6D9,P42574,Q14160,Q96J02,P10644,Q92990 6 +Protein ufmylation 0.514332570522748 0.4985777580596909 0.6180768774194694 1.0 0.8373514536986251 5 P61960 1 +Positive regulation of oxidative stress induced cell death 0.5106525275728108 0.4978839951139241 0.6185658087027139 1.0 0.8375460485040997 4 P23246,Q13546 2 +Cardiac muscle cell proliferation 0.5106227106227121 0.4977734682351874 0.6186437184181446 1.0 0.8375460485040997 4 Q16539,Q12948,P06493 3 +Meiotic sister chromatid cohesion centromeric 0.4562431343830099 0.496979379657584 0.6192035925465453 1.0 0.8375460485040997 3 O43683,O60566 2 +Regulation of gene silencing by rna 0.356079944112497 0.4949282463673937 0.6206507711753768 1.0 0.8388472640342337 17 O75844,Q01085,Q14671,P36507,Q13546 5 +Fucose metabolic process 0.4553919103143944 0.4935283609414941 0.6216393055842577 1.0 0.8393591962717843 3 Q9BTY2 1 +Uv protection 0.509453602482628 0.4934452236139339 0.6216980348301684 1.0 0.8393591962717843 4 P19447,Q9BRK5 2 +Lymphocyte apoptotic process 0.3723529690053951 0.4929843233465233 0.6220236642266821 1.0 0.8393747377002703 15 Q9HCL2,P24390,Q13546 3 +Positive regulation of peptide secretion 0.4528765045845326 0.4892991070633032 0.6246299531539272 1.0 0.8422308517827224 9 P22059,P00367 2 +L glutamate transmembrane transport 0.4780894212732154 0.4886407674860579 0.6250960454649728 1.0 0.8426566360519553 7 Q9UJS0,O60831,Q15041 3 +Regulation of peptidyl lysine acetylation 0.3713632805819701 0.4869104298279825 0.6263218073559769 1.0 0.843651340707925 15 O75844,Q13363 2 +Lymphocyte activation 0.2769235760750724 0.4868630974755447 0.6263553518699647 1.0 0.843651340707925 89 P49366,Q9HCL2,P23396,P24390,P04062,P51809,P30825,P46379,P62942,P17812,Q96J02,P00813,O96005 13 +Regulation of embryonic development 0.378452959685381 0.4844957111987962 0.628034107356001 1.0 0.8453683803561265 14 P46379 1 +Proteasomal protein catabolic process 0.2697815583099323 0.4840594445559338 0.6283436821976791 1.0 0.8454225539727881 143 Q9UBU6,P46379,Q9Y679,Q9BUN8,Q96A33,Q8TCT9,P48729,Q99436,O76024,P60604,P49721,O95260,Q9NXV2,P28070,Q9UJX4,Q96J02,P04062,P20618,P28072,P48556,P51572 21 +Mitotic dna replication checkpoint signaling 0.4528626855137005 0.4833174670821403 0.6288703396031106 1.0 0.8458452148879136 3 Q9Y619 1 +Glycolipid biosynthetic process 0.4527100353450144 0.4827032786212396 0.6293064349678035 1.0 0.8461738699352903 3 Q8NBX0 1 +Paraxial mesoderm development 0.4525814719882828 0.4821861893672508 0.6296736867529948 1.0 0.846486382320193 3 Q96A65,Q12948 2 +Exocytic process 0.3520569985279196 0.4796358311629755 0.6314863633950674 1.0 0.8476499087624468 18 Q7Z6M1,P51809,P61006 3 +Cellular response to fatty acid 0.5090995065482796 0.4790170076229762 0.6319265293764729 1.0 0.847794987649657 5 Q15120 1 +Vesicle docking 0.3697172350980263 0.4768342054291798 0.6334801863857844 1.0 0.8484565756443968 15 Q7Z6M1,O15400,P61006,Q13190,Q9UEU0 5 +Mammary gland duct morphogenesis 0.4511168070303919 0.4763072852254882 0.6338554759584267 1.0 0.8486552949599069 3 Q15648,Q14160 2 +Cellular respiration 0.2730524763162187 0.4750142357769712 0.6347768265567673 1.0 0.8495294806011833 96 Q15070,P13073,O75964,O95168,P14406,O14949,P21912,P43304,O75306,Q13423,O96000,Q9Y6M9,Q9BSK2,Q9NZ45,P04062,O43676,Q9UDW1 17 +Natural killer cell mediated immunity 0.4496670577810416 0.4746862570742601 0.6350106148418333 1.0 0.849658277914968 9 P51809 1 +Positive regulation of intracellular transport 0.298408308468526 0.472803394373734 0.6363534521701162 1.0 0.8499209510346895 56 Q9Y282,Q9P2W9,O75312,Q9H6U6,Q07666,Q15154,Q9NR31,P51572,P27105,P31751,P50402,P55786 12 +Rna destabilization 0.3075161778000557 0.4651615423506179 0.6418157768062334 1.0 0.8549372897919654 37 Q969T7,O60506,O95453,Q14103,P67809,Q14671,Q92945,Q9NPI6 8 +Pteridine containing compound metabolic process 0.3496784585899496 0.4635755347890024 0.6429518859424173 1.0 0.8557243883711035 18 P04818,Q99707,P41440,Q9H2D1,P13995 5 +Regulation of glucose transmembrane transport 0.4205407767502284 0.462522228554231 0.6437068655724003 1.0 0.8557269091859543 11 Q16625,O75298,P52789,P31751 4 +Protein localization to cilium 0.3746392759492483 0.4621043723190636 0.6440064748704721 1.0 0.8557269091859543 14 A0AVF1,P61006 2 +Positive regulation of actin filament polymerization 0.4196986516012359 0.4583312491219636 0.6467144767683639 1.0 0.8570980547079984 11 Q9UQB8,O95429 2 +Circadian rhythm 0.3038971526555252 0.4540694384559302 0.649778849153712 1.0 0.8588201576564389 40 Q9NRV9,Q14103,P54802,Q15233,Q05086,Q9BWF3 6 +Protein localization to synapse 0.4575828138645178 0.4539288106034924 0.6498800662927826 1.0 0.8588201576564389 8 P61006,Q14168 2 +Postsynaptic cytoskeleton organization 0.4985314683352839 0.4535434457741584 0.6501574664014675 1.0 0.8588201576564389 4 Q16352 1 +Endosome organization 0.3288185054062016 0.4531725196607872 0.6504245187764093 1.0 0.8588201576564389 27 Q8NEB9 1 +Regulation of amino acid transport 0.5017065743367489 0.4517526241279598 0.6514472029274552 1.0 0.8590181768490996 5 Q7L0J3 1 +Amine transport 0.5017065743367489 0.4517526241279598 0.6514472029274552 1.0 0.8590181768490996 5 Q7L0J3 1 +Sensory perception of mechanical stimulus 0.3655610325646625 0.4515417879784699 0.651599114309144 1.0 0.859038059561698 15 Q14108,Q9Y6M9,P62072 3 +Regulation of fat cell differentiation 0.3997621295756375 0.4510214181757562 0.6519741123545173 1.0 0.8593519792907116 12 Q99523,Q8N4Q0 2 +Response to vitamin d 0.4803504543716658 0.4500801140397357 0.6526526750743764 1.0 0.8593581411386796 6 O15164,Q8TB36 2 +Positive regulation of dephosphorylation 0.3809738209184867 0.4494960460672703 0.6530738597280408 1.0 0.8593581411386796 13 P04062,Q86XL3 2 +Positive regulation of protein dephosphorylation 0.3809738209184867 0.4494960460672703 0.6530738597280408 1.0 0.8593581411386796 13 P04062,Q86XL3 2 +Ethanol metabolic process 0.4441596484804103 0.4486937968629544 0.6536525600644381 1.0 0.8595961874733982 3 P11766,P30837 2 +Regulation of phosphatidylinositol 3 kinase signaling 0.4679516958151046 0.4469018145812714 0.6549459537526618 1.0 0.8605589572329868 7 Q05086 1 +N terminal protein amino acid modification 0.4431960181826045 0.4455231984040029 0.6559416988399824 1.0 0.861146379196447 9 P53582,Q86UY6,P41227 3 +Muscle adaptation 0.3800511026231656 0.4443571356196777 0.6567843987678423 1.0 0.861506881546052 13 Q13555,P09601,P49840,P16615 4 +Axon development 0.290586402265193 0.4438142561160511 0.6571768804912461 1.0 0.861506881546052 63 O00264,Q9NQC3,Q96G23,P61006,O75312,Q9UQB8,Q99707,P07196,Q8N0X7,P41440,P42892,P05067,Q13153 13 +Coenzyme a metabolic process 0.4546077900828749 0.4412287422723782 0.6590474071967947 1.0 0.8628779191619348 8 Q13057,P35610,Q9HCC0,Q8WVC6 4 +Vesicle targeting rough er to cis golgi 0.4293929220896698 0.4409816804318719 0.6592262595124834 1.0 0.8629321220223876 10 Q9HCU5,O15027 2 +Regulation of mitochondrial gene expression 0.4414801820884739 0.437860806694795 0.6614871885600202 1.0 0.8646297251259227 9 Q9Y2R0 1 +Negative regulation of immune response 0.336628069848134 0.4372948651116566 0.6618975188079399 1.0 0.8649859748285277 22 P14373,P09601,P28070 3 +Regulation of generation of precursor metabolites and energy 0.3085186231309919 0.4360897364702162 0.6627716234639496 1.0 0.8654077063449824 34 P14406,Q9BSK2,Q9NZ45,P05067,P31751 5 +Organic acid biosynthetic process 0.2814026633067931 0.4352958046544805 0.663347729718903 1.0 0.865619839362975 71 P09960,Q13126,Q99707,A1L0T0,P00367,P22059,Q53GQ0,Q9BY49,Q8NCG7,O00767,Q9H7Z7,Q9P035,Q9BZF3 13 +Positive regulation of inflammatory response 0.369907454898472 0.4345738722153098 0.6638717634386242 1.0 0.8656538182817405 14 P05067,P51809,Q13546 3 +Positive regulation of receptor internalization 0.4404855026454863 0.4343263831348714 0.6640514477795965 1.0 0.8656538182817405 3 Q8NBU5 1 +Regulation of lipid localization 0.3412410974432687 0.4338150263305936 0.6644227690121169 1.0 0.8659427327917937 20 Q8WTV0,P31751 2 +Vasculogenesis 0.4646347140285493 0.4334507379079464 0.6646873469392443 1.0 0.8660276517727256 7 Q4VCS5 1 +Regulation of response to wounding 0.3779558173901106 0.4327277522124806 0.6652125657297294 1.0 0.8660276517727256 13 Q96G23 1 +Regulation of monooxygenase activity 0.4276112778722056 0.4326429113843868 0.6652742098122069 1.0 0.8660276517727256 10 Q8WTV0,Q8TCT9 2 +Regulation of lymphocyte apoptotic process 0.4757892382697014 0.4324123952248265 0.6654417108465871 1.0 0.8660276517727256 6 Q9HCL2 1 +Regulation of establishment of protein localization to mitochondrion 0.3774885719918869 0.430142112496163 0.6670922678545086 1.0 0.8668288503491863 13 P55786 1 +Negative regulation of endocytosis 0.426027605729481 0.4252600082978087 0.6706471433934107 1.0 0.8686450930934253 10 Q13432 1 +Phosphatidylinositol 3 kinase signaling 0.4505285709870815 0.4239583187954466 0.6715962113792355 1.0 0.8688694010638622 8 Q05086 1 +Negative regulation of catabolic process 0.2725455995046329 0.4203530619138481 0.6742275521474184 1.0 0.8709466198315828 88 Q99729,Q16850,P35637,O60506,O15118,P46379,Q92804 7 +Galactose catabolic process 0.3850658857979445 0.4193285336124981 0.674976046048352 1.0 0.8711964673296781 2 P16278 1 +Galactose metabolic process 0.3850658857979445 0.4193285336124981 0.674976046048352 1.0 0.8711964673296781 2 P16278 1 +Antigen processing and presentation 0.3411761780051896 0.418869905400055 0.6753112122219389 1.0 0.8713670258576794 19 P01889,P04062,Q9UIQ6,Q9BZG1 4 +Regulation of vesicle mediated transport 0.2675202511355439 0.4163811245621023 0.6771311382678744 1.0 0.8729012907691408 99 P50897,P41440,P61978,P16615,Q8WTV0,Q9HCU5,Q9NR31,Q13432,P09601,P36507,P05067,O14936,Q8NBU5,P50570,Q6NUQ1,P31751,P61006,Q9P2W9,P51809 19 +Insulin secretion 0.3407346546792971 0.4158805563396662 0.6774974080232854 1.0 0.8730422840657249 19 P00367,P22059,P40939,Q16836,Q13555 5 +Regulation of telomerase activity 0.3424797171296864 0.4154600287419834 0.6778051703606274 1.0 0.8730531102839595 18 P27544,Q14103,P22626,Q96HR8 4 +Regulation of metal ion transport 0.2938056453333426 0.4136321718128445 0.6791435083009709 1.0 0.873761922314111 46 O14936,Q96GC9,P14373,P21796,P50570,P62942,O76024,O43865,O75323,Q13555 10 +Antigen processing and presentation of exogenous peptide antigen 0.4872234915734065 0.4133209459140526 0.6793714856374999 1.0 0.873761922314111 4 Q9UIQ6 1 +Negative regulation of calcineurin mediated signaling 0.4350054924935921 0.4131879825334458 0.679468892121295 1.0 0.873761922314111 3 P49841,P42345 2 +Negative regulation of calcium mediated signaling 0.4350054924935921 0.4131879825334458 0.679468892121295 1.0 0.873761922314111 3 P49841,P42345 2 +Pallium development 0.3057917003434721 0.4116593909083682 0.6805890937815136 1.0 0.8746649602375316 34 Q9NQC3,O14949 2 +Skeletal muscle contraction 0.4335408275357014 0.4075990432523386 0.6835680668327777 1.0 0.8759031036853863 3 P78417,P10253 2 +Negative regulation of defense response 0.3161992976571853 0.4070233866948649 0.6839908116176043 1.0 0.8759031036853863 30 P28070,Q96J02,P01889,P04062,O43657 5 +Regulation of transporter activity 0.301274931466965 0.4069152838831192 0.6840702101085159 1.0 0.8759031036853863 37 Q96GC9,P50570,P62942,P05067,O43865,O75323,P08183,Q13546 8 +Regulation of protein adp ribosylation 0.4846153846153862 0.404212446811037 0.6860565016583313 1.0 0.8768247691419293 4 P18887,Q9H2P0,Q15397 3 +Interleukin 6 production 0.4085940693168541 0.4038126948773163 0.6863504604967361 1.0 0.8768247691419293 11 P05067,P04062 2 +Cellular modified amino acid metabolic process 0.2922536423539217 0.402117354051539 0.6875976616199471 1.0 0.8769158432420668 51 Q8NCC3,O60725,P23786,Q9H2D1,Q9UHG3,Q9H7Z7 6 +Regulation of immune system process 0.2596711148693119 0.4020484001450733 0.6876484065435959 1.0 0.8769158432420668 172 P14373,P46379,P41440,P01889,Q9NPR9,Q13546,Q9NQC3,P23246,P23396,P09601,P05067,P00813,Q13153,Q96PK6,P49366,P53634,Q9HCL2,Q00013,O15400,P49770,P30825,P62942,P28070,Q96J02,O43657,O96005,Q5JVF3,Q07666,Q8TCT8,P43243,P51809,Q15233 32 +Phospholipid dephosphorylation 0.4314501563942784 0.399666963463228 0.6894018279382164 1.0 0.8781179658391464 3 Q10713 1 +Negative regulation of dephosphorylation 0.3562479812608464 0.395718010471563 0.6923130673978379 1.0 0.8792922187181118 15 P62942,O95429,O75663,Q15257,Q12972 5 +Macrophage activation 0.4651620376045488 0.3920243352204079 0.6950402331450447 1.0 0.881685710989006 6 P05067 1 +Aerobic respiration 0.2721754349049316 0.3917580011768659 0.6952370297286441 1.0 0.8817054427764076 81 Q15070,P13073,O75964,O95168,P14406,O14949,P21912,O75306,O96000,Q9Y6M9,O43676,Q9UDW1 12 +Glutamine metabolic process 0.3704637485396893 0.3916231568260341 0.695336675244663 1.0 0.8817054427764076 13 P00367,Q06203,P17812 3 +Regulation of viral entry into host cell 0.4643460968560796 0.3889705208647562 0.6972979535075332 1.0 0.8828555078460403 6 P14373,Q12899 2 +Engulfment of apoptotic cell 0.3777452415812563 0.3886848519032585 0.6975092894100605 1.0 0.8828555078460403 2 P84095 1 +Cellular response to mineralocorticoid stimulus 0.4280483339436103 0.3868772327727321 0.6988470968635885 1.0 0.8829603892857075 3 P20020,O95831 2 +Protein localization to vacuole 0.3471483499850194 0.3851868637812502 0.7000989751068405 1.0 0.8839946431457651 16 Q9NQC3 1 +Regulation of mirna metabolic process 0.3766471449487494 0.3841636669662304 0.7008571455487671 1.0 0.884240586767516 2 Q8TCS8 1 +Positive regulation of mirna metabolic process 0.3766471449487494 0.3841636669662304 0.7008571455487671 1.0 0.884240586767516 2 Q8TCS8 1 +Protein acylation 0.29329664809723 0.3809059904607802 0.7032730072490265 1.0 0.8863978999215797 43 P46379,Q13363,O75844,P16435 4 +Regulation of lipid transport 0.3597913124796192 0.3767506460805921 0.7063589212682144 1.0 0.8880562518997386 14 P31751 1 +Excretion 0.4804604423558462 0.376066756330601 0.7068672679177634 1.0 0.8880562518997386 5 P09601,P04899 2 +Regulation of the force of heart contraction 0.4763816591180382 0.3758969707048429 0.7069934926720123 1.0 0.8880562518997386 4 P16615 1 +Regulation of systemic arterial blood pressure 0.4269407392294357 0.3742231280898543 0.7082383183183747 1.0 0.8889009966861532 9 P42892 1 +Long chain fatty acyl coa metabolic process 0.4489875758585531 0.3715049367173961 0.7102614796657882 1.0 0.8907354313507428 7 Q53GQ0,O60488 2 +Sarcoplasmic reticulum calcium ion transport 0.459023085132854 0.3692213345135899 0.7119627549617698 1.0 0.8913947300536267 6 O75844 1 +Lymphocyte homeostasis 0.4256113367661202 0.3685272872549971 0.7124801023375147 1.0 0.8913947300536267 9 Q9HCL2 1 +Regulation of lipid catabolic process 0.4370233585301455 0.3680521015487329 0.7128343852132051 1.0 0.8913947300536267 8 Q8WTV0,P31751 2 +Alcohol catabolic process 0.4134850037930551 0.3678248906860388 0.713003808082338 1.0 0.8913947300536267 10 Q8WTV0,Q10713 2 +Cellular response to starvation 0.3137958624427182 0.3676725373578811 0.713117420344139 1.0 0.8913947300536267 29 P21964,P04062,Q8NEB9 3 +Regulation of establishment of planar polarity 0.4585939998459503 0.3676426919710737 0.7131396772618488 1.0 0.8913947300536267 6 Q8TAA9 1 +Positive regulation of protein modification by small protein conjugation or removal 0.2963061812892523 0.3668745415291932 0.7137126022412412 1.0 0.8915017343554541 38 Q9BUN8,Q9BTE7,P62942,Q92564,Q05086 5 +Regulation of oxidative phosphorylation 0.4364046558930384 0.3655406517459014 0.7147078673902612 1.0 0.8922108721658736 8 P14406 1 +Positive regulation of histone ubiquitination 0.4732600732600751 0.3653429749594499 0.7148554027821052 1.0 0.8922108721658736 4 Q6PD62,O60341,Q5VTR2 3 +Immune response regulating cell surface receptor signaling pathway 0.3210805650644101 0.365161434313788 0.7149909044068987 1.0 0.8922108721658736 25 P23396,P49770,Q07666,P46379,Q9NR50,P00813,Q13153 7 +Regulation of mitotic cell cycle spindle assembly checkpoint 0.457432478710669 0.363379526710045 0.7163213933739621 1.0 0.8929836591742919 6 Q5JVF3,P14635,Q9Y6D9 3 +Atp metabolic process 0.2639278289379447 0.3630788375536613 0.7165459926800624 1.0 0.8930863097171792 99 Q9BRR6,P13073,O75964,O95168,P14406,O14949,O75306,O96000,Q9Y6M9,P14618,P05067,O43676,Q9UDW1 13 +Telencephalon development 0.2968174804509585 0.3610133986710659 0.7180894308948367 1.0 0.8941224607611631 36 Q9NQC3,O14949 2 +Hair follicle maturation 0.4209203491208301 0.3605645225640653 0.7184250145337683 1.0 0.894362927075748 3 P18074 1 +I kappab kinase nf kappab signaling 0.2900457217146308 0.3602120277254682 0.7186885807860763 1.0 0.8945136618110601 44 P14373,P62942,Q8TB61,P09601,O43657,Q9P035,Q13546 7 +Regulation of mrna export from nucleus 0.4564007400868479 0.3596052574536332 0.719142351381117 1.0 0.8947236785514572 6 Q9ULX6,Q96ST2 2 +Detection of stimulus 0.3644565471592564 0.3592480870060384 0.7194095061070558 1.0 0.8948787159382001 13 Q8WTV0 1 +Organic hydroxy compound transport 0.3182143152505296 0.3556904449752965 0.7220724014984254 1.0 0.8960758558348738 26 Q8WTV0,O15118,Q9BZF3 3 +Positive regulation of endocytosis 0.3559374079044811 0.3551301117167779 0.7224921191026206 1.0 0.8964042537008402 14 P41440,P50897,Q8NBU5,P61978 4 +Regulation of smoothened signaling pathway 0.4441713168906406 0.3529772431433446 0.7241055011854833 1.0 0.8968108771833624 7 P16435 1 +Nuclear pore organization 0.3629774140538889 0.3513618640439088 0.7253168888352386 1.0 0.8976464843962082 13 Q9NQC3 1 +Organelle inheritance 0.4327657287253886 0.3508628052621442 0.7256912767969079 1.0 0.8978892068843098 8 Q13190 1 +Regulation of dna primase activity 0.4688644688644706 0.3506570324002377 0.7258456642441191 1.0 0.8979032670196215 4 Q9BRX5,Q9BRT9,Q9Y248 3 +Positive regulation of amyloid beta formation 0.4681318681318698 0.348229727789681 0.7276676637394499 1.0 0.8984130263307069 4 P42574,O75116,P49840 3 +Blood vessel endothelial cell migration 0.3265569464011829 0.3479232429756717 0.7278978291511553 1.0 0.8984130263307069 21 P42785,Q8WTV0,P09601 3 +Response to fatty acid 0.4201778607017186 0.3454777928726896 0.7297352024574075 1.0 0.8984130263307069 9 O00767,Q15120 2 +Myeloid leukocyte mediated immunity 0.3791519175116795 0.3454621306340638 0.7297469751955576 1.0 0.8984130263307069 12 P09601 1 +Negative regulation of hydrolase activity 0.2836244685304621 0.3444673893904329 0.7304948165891902 1.0 0.8985875096959539 61 Q99523,Q15392,Q9H6U6,P16435,P62942,Q96K76,O95429,P05067,Q4VCS5 9 +Negative regulation of transforming growth factor beta receptor signaling pathway 0.4082502064475412 0.3444400895516592 0.7305153440851639 1.0 0.8985875096959539 10 P62942,P50570,Q92896 3 +Cardiac ventricle development 0.3613342621725348 0.3426423829883028 0.7318675130707109 1.0 0.8990544320043363 13 O75844,P43243,P62942,P49840 4 +Negative regulation of protein acetylation 0.4193185665968049 0.3418673252811053 0.732450740329798 1.0 0.8991771251269328 9 Q13363 1 +Regulation of cell cell adhesion 0.290178062960935 0.3402687635128981 0.7336541382769615 1.0 0.8999155498641731 42 Q9HCL2,P23396,P30825,P41440,Q96J02,P00813 6 +Nuclear envelope organization 0.3161501562082118 0.340020819569934 0.7338408492998898 1.0 0.8999155498641731 26 O75844,Q86XL3,Q8N1F7,Q9ULX6 4 +Regulation of insulin receptor signaling pathway 0.3775313304866444 0.3374159760173449 0.7358033429545727 1.0 0.9015170544630772 12 Q8TBX8,Q9HCD5,P11802 3 +Calcium mediated signaling 0.339140419818271 0.3364835466997738 0.7365062568440239 1.0 0.9022022010666892 16 O75844,P16615 2 +Neurotransmitter transport 0.3206241232071979 0.3359649911302452 0.7368972665774991 1.0 0.9023290500436004 23 O14936,P50897,P16615 3 +Negative regulation of defense response to virus 0.4387932543050861 0.3326125048522046 0.7394268028412645 1.0 0.904069567147768 7 O43657 1 +Positive regulation of defense response 0.2931625777080545 0.3325543230112853 0.7394707275093642 1.0 0.904069567147768 37 P23246,P53634,P43243,P05067,P51809,Q13153,Q15233,Q13546 8 +Neurotransmitter secretion 0.3296463532430738 0.3317997438404442 0.7400404777210776 1.0 0.9042429368032976 18 O14936,P16615 2 +Neuron projection regeneration 0.4277168091871669 0.330769772394548 0.7408183949826523 1.0 0.9044842247571162 8 Q99707,Q96G23 2 +Photoperiodism 0.447844911428671 0.3287751995224493 0.7423256098388218 1.0 0.9054439826244652 6 Q9BWF3 1 +Entrainment of circadian clock 0.447844911428671 0.3287751995224493 0.7423256098388218 1.0 0.9054439826244652 6 Q9BWF3 1 +Positive regulation of ion transport 0.2931992197750032 0.3248904480528818 0.7452639864281543 1.0 0.9079695918486226 35 O14936,Q96GC9,P51809,O76024,O43865,O75323,P08183 7 +Regulation of gtp binding 0.4461769577041325 0.3228652680730606 0.7467972808484742 1.0 0.9086840506934746 6 O75503 1 +Photoreceptor cell development 0.4602758650606707 0.3225774975530496 0.747015237774407 1.0 0.9086840506934746 4 P54802 1 +Positive regulation of neuron projection development 0.3187440091475736 0.3225476633018168 0.7470378353458424 1.0 0.9086840506934746 23 Q9UQB8,Q32P28,Q14108 3 +Ribonucleoside monophosphate metabolic process 0.3121183084084655 0.32253031053664 0.747050979075571 1.0 0.9086840506934746 27 O14936,Q00013,Q14168,P55263 4 +Positive regulation of monooxygenase activity 0.4645732206616459 0.3223955099615956 0.7471530853264918 1.0 0.9086840506934746 5 Q8WTV0 1 +Leukocyte differentiation 0.2834824060874282 0.3205889587087485 0.7485219059900745 1.0 0.9087546417631476 58 O96005,P24390,Q14739,O00625,P01889,P04062,P05067 7 +Cell projection organization 0.2569321377884642 0.3192945239279258 0.749503184812599 1.0 0.9087546417631476 211 O00264,Q32P28,A6NIH7,Q9Y277,P25054,P07196,P41440,Q9NR77,Q9NQC3,Q96G23,Q14108,O95684,Q99707,Q15154,Q86X55,P42892,P48681,P05067,Q9NUL3,Q13153,P08670,Q9H6U6,Q16625,O95487,O95429,Q9H4A6,P04062,Q05086,Q13555,P61006,O75312,Q9UQB8,Q8N0X7,A0AVF1,Q9BZG1,Q8WWV3 36 +Response to activity 0.3906300059254763 0.3189478000974937 0.7497660964694357 1.0 0.9087546417631476 11 Q9UDX5,P06493,Q15388,O43819,P31930,P40939,Q16836 7 +Golgi vesicle transport 0.2601395847264286 0.3189452183032317 0.7497680542859269 1.0 0.9087546417631476 116 P24390,P35606,Q96PC5,Q9HCU5,Q9NR31,O15127,Q13190,Q9Y282,Q8TD16,O95487,Q9H4A6,Q6NUQ1,Q99523,P61006,Q9P2W9,P51809,O15126,O15027,Q9BZG1,Q96RQ1,P51572,Q9UEU0 22 +Fibroblast migration 0.3493844511792103 0.3189391860905002 0.749772628617027 1.0 0.9087546417631476 14 O95429,Q5SNT2 2 +Response to thyroxine 0.360175695461196 0.3188811109902701 0.7498166684187806 1.0 0.9087546417631476 2 P48507 1 +Response to l phenylalanine derivative 0.360175695461196 0.3188811109902701 0.7498166684187806 1.0 0.9087546417631476 2 P48507 1 +Neuron differentiation 0.255337220896231 0.3176522830363326 0.7507487103988875 1.0 0.9088315472202498 173 O00264,Q32P28,P50897,P41440,Q9NR77,Q9NQC3,Q96G23,Q14108,Q99707,O14949,P42892,P54802,P05067,Q9NUL3,O75503,P08670,Q8WUJ1,O95487,P04062,Q05086,Q13555,P61006,Q9UQB8,Q9NZJ7,Q8N0X7,Q8WWV3 26 +Rac protein signal transduction 0.4018370239886821 0.3163048046549017 0.7517711646450258 1.0 0.9097184602238768 10 Q68EM7,Q9P035 2 +Multicellular organismal movement 0.4341767510084364 0.3154160631626267 0.7524457721983153 1.0 0.9103593289383356 7 P78417,P18887,Q96QK1,Q6Y7W6,P42345,P10253 6 +Regulation of synaptic vesicle exocytosis 0.401484698410943 0.314776196758384 0.7529315859180143 1.0 0.9105311024192512 10 P16615 1 +Coenzyme a biosynthetic process 0.4438414064172489 0.3146467383080791 0.7530298881738546 1.0 0.9105311024192512 6 Q13057,P35610,Q8WVC6 3 +Antigen processing and presentation of peptide antigen via mhc class i 0.4234419032857485 0.3140142430443656 0.7535102211367029 1.0 0.9105311024192512 8 Q9UIQ6 1 +Androgen metabolic process 0.4620126112728653 0.3140037507039708 0.7535181900913803 1.0 0.9105311024192512 5 P51659,O95470,Q15648 3 +Dendrite extension 0.4075430245331381 0.3130737431027589 0.7542246370347214 1.0 0.9105812060199964 3 Q7L576,O60271 2 +Ear development 0.335027140256218 0.3119225061967994 0.7550994177749109 1.0 0.9111116941746858 16 P42892,P54802 2 +Regulation of transmembrane receptor protein serine threonine kinase signaling pathway 0.3138221567222262 0.3111757470215353 0.7556670194753825 1.0 0.9113101564656358 25 Q93062,Q92896,P62942,Q8N0X7,Q8N1F7 5 +Regulation of cellular response to transforming growth factor beta stimulus 0.3552503383085204 0.3107513019235671 0.7559896933534616 1.0 0.9113101564656358 13 P62942,P50570,Q92896 3 +Regulation of protein binding 0.2869978029954994 0.3098288232362782 0.7566911316429339 1.0 0.9117175083209784 42 Q9BUN8,P62942,P05067,O75381,P16615 5 +Leukocyte cell cell adhesion 0.2905975495877421 0.3094090347937931 0.7570103985895589 1.0 0.9117175083209784 37 Q9HCL2,P23396,P30825,Q9H4A6,Q96J02,P00813 6 +Regulation of protein dephosphorylation 0.3102736177733463 0.3084690014476562 0.757725484224621 1.0 0.9123514748680804 27 P62942,Q86XL3 2 +Mitochondrial protein processing 0.4410629581482737 0.3049575810445692 0.760398459772466 1.0 0.9146905445120914 6 Q96TA2,Q10713,Q99797 3 +Negative regulation of gtpase activity 0.4102185918027748 0.3042449671085462 0.7609412687513644 1.0 0.9146905445120914 9 Q4VCS5 1 +Regulation of cell population proliferation 0.2563458032628331 0.3038269021079336 0.7612597700780026 1.0 0.9146905445120914 193 Q32P28,P11802,P98175,P25054,Q9NNW5,Q96DY7,Q9NR77,Q9BSK2,O60884,Q15637,Q9NQC3,Q96G23,Q15392,P43307,P14635,O95684,O15164,P23396,P16435,P09493,Q13363,Q86X55,P09601,P48681,P05067,O14936,P00813,Q13153,Q14534,P49366,Q9HCL2,P30825,Q96J02,P57105,P31751,P55209,O75844,Q52LJ0,Q01085,P50402 40 +Positive regulation of amino acid transport 0.4031490296594656 0.2980465827570812 0.7656676104236251 1.0 0.9178596252053848 3 Q15041,Q15042 2 +Positive regulation of amine transport 0.4031490296594656 0.2980465827570812 0.7656676104236251 1.0 0.9178596252053848 3 Q15041,Q15042 2 +Regulation of amino acid transmembrane transport 0.4031490296594655 0.2980465827570806 0.7656676104236255 1.0 0.9178596252053848 3 O75915,Q15041 2 +Regulation of l glutamate import across plasma membrane 0.4031490296594655 0.2980465827570806 0.7656676104236255 1.0 0.9178596252053848 3 O75915,Q15041 2 +L glutamate import across plasma membrane 0.4031490296594655 0.2980465827570806 0.7656676104236255 1.0 0.9178596252053848 3 O75915,Q15041 2 +T cell mediated immunity 0.4086460907876964 0.2978613728084857 0.7658089705042697 1.0 0.9178596252053848 9 P01889,O15400,P53634 3 +Water soluble vitamin metabolic process 0.3240996939409793 0.296617230133241 0.7667587548409691 1.0 0.9181215836146488 18 P11166,Q9H2D1,Q96EY8,P41440 4 +Regulation of protein acetylation 0.3239332950718623 0.2955718356235179 0.7675570849912394 1.0 0.9187270504432796 18 O75844,O00571,Q13363,Q01105,Q96ST2 5 +Adipose tissue development 0.3968706496557944 0.2949281515914347 0.7680487660857915 1.0 0.9191403266272588 10 Q8N0X7,O15173,P11802 3 +Vascular process in circulatory system 0.3055515138698936 0.2864569217278234 0.774528183071383 1.0 0.9235494650184506 28 P41440,P42892,P08183,P30825 4 +Regulation of jnk cascade 0.3827471705252036 0.2832077684974194 0.7770175736392493 1.0 0.9258144481509218 11 P05067,Q969S3,Q13546,Q96J02 4 +Homeostatic process 0.2483657474307788 0.2822859914692194 0.7777242261699682 1.0 0.9260454203360736 256 Q9HC07,P50897,O75027,O15118,P23786,P25054,P51790,Q8IYU8,Q9HCD5,Q9Y487,P16615,Q96AQ8,Q9NX40,Q93050,Q8WTV0,Q9NQC3,Q96A33,Q9P035,Q15067,P11166,O14773,Q9UIQ6,O76024,Q8NE01,P09601,Q14157,P05067,Q8WWC4,P00813,Q8N511,P62995,O75503,Q9UM00,P49366,Q9HCL2,O95202,O15254,Q9HD20,Q15120,P62942,P22059,O43847,P30519,P40939,P04062,Q05086,P42785,Q9BWH2,Q5BJF2,P06737,O00767,Q16836,P51572 53 +Positive regulation of cell activation 0.2870203337949062 0.2820775493590715 0.7778840475350737 1.0 0.9260454203360736 38 P49366,P53634,Q9HCL2,P23396,P30825,P00813,P51809 7 +Negative regulation of epithelial cell apoptotic process 0.4513488482181816 0.2798817225412363 0.7795682503456289 1.0 0.9277970569990254 5 P09601 1 +Positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 0.4465201465201485 0.2794063239365807 0.7799330184673083 1.0 0.927897072100186 4 P49841,P49840,Q9UII2 3 +Modification of synaptic structure 0.4142536274318242 0.2788431749213519 0.7803651792046011 1.0 0.928041787279122 8 Q9UQB8 1 +Heart morphogenesis 0.312330406251643 0.2773864186209036 0.7814834090029092 1.0 0.9285856124585554 23 P62942,Q9NQC3 2 +Multi organism reproductive process 0.258342380758696 0.2772840285140935 0.7815620223368918 1.0 0.9285856124585554 132 Q9BQE5,P14373,Q9H9C1,P46379,P45880,P41440,P11166,O95470,Q15067,Q9UIQ6,Q14157,P05067,Q96GC9,Q05086,Q07666,Q01085,Q9BTX1,A0AVF1,P51572 19 +Regulation of attachment of spindle microtubules to kinetochore 0.450418611624662 0.2769702686870125 0.7818029355426765 1.0 0.9286960888054728 5 P25054 1 +Negative regulation of endoplasmic reticulum stress induced intrinsic apoptotic signaling pathway 0.4327166583037817 0.2764453530727182 0.7822060266243185 1.0 0.928999136425931 6 O76024 1 +Mononuclear cell differentiation 0.2843046213889969 0.2761831597951419 0.7824073909419651 1.0 0.929062530798876 41 P04062,O96005,O00625,P24390 4 +Nuclear transcribed mrna catabolic process nonsense mediated decay 0.3352920002590169 0.2752974034393685 0.7830877591846821 1.0 0.9295188035850698 15 P60228,Q99729,Q15287,Q9NPI6 4 +Positive regulation of g protein coupled receptor signaling pathway 0.3960896774011711 0.2745301990513862 0.7836771992642733 1.0 0.9298699552409372 3 P49840 1 +Histone h3 k9 demethylation 0.3958257048700112 0.273666186343836 0.7843411654250392 1.0 0.9299516216314252 3 Q9UPP1,O60341 2 +Central nervous system development 0.2547028717644277 0.2731675776232296 0.7847244017760113 1.0 0.9300547091466488 159 P50897,P07196,P46379,Q86XL3,P51648,P11166,Q9NQC3,P61960,O14773,O14949,Q15154,Q14103,P00367,P48681,P54802,P05067,P62995,O75503,P08670,Q16352,Q96N66,P49770,O95487,Q9BRK5,P04062,Q05086,O75312,Q9UQB8,O15027,Q9BSJ2 30 +Intermediate filament based process 0.379933956136656 0.2706981447154265 0.7866232038574146 1.0 0.9307908979766796 11 Q16352,P48729,P07196,P07197,P08670 5 +Negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway 0.3400133353312749 0.2685542101763263 0.7882727530642135 1.0 0.9316220526613578 14 Q8N0X7,P50570,Q92896,P62942 4 +Associative learning 0.4003823956665097 0.2649181466311038 0.7910725186493641 1.0 0.9338761323957706 9 P05067,O00264 2 +Nuclear membrane organization 0.3184032306255371 0.2611836980211099 0.7939508490166283 1.0 0.9360911976126078 18 Q86XL3,Q9ULX6 2 +Response to osmotic stress 0.32633136423376 0.2611295382703525 0.7939926134576516 1.0 0.9360911976126078 16 P11166,P08183 2 +Cellular protein catabolic process 0.2540123599041304 0.2602067064438199 0.7947043314067852 1.0 0.9365785231033972 212 P50897,Q9UBU6,P46379,Q9Y679,Q13546,Q9BUN8,Q96A33,O14773,Q8TCT9,P48729,Q99436,O76024,Q8N511,P60604,P53634,P49721,O95260,Q9NXV2,Q96K76,P28070,Q9UJX4,Q96J02,P04062,Q05086,P20618,O75844,P28072,P48556,Q9UHG3,P51572 30 +Positive regulation of establishment of protein localization 0.2658857967777221 0.2563627535474236 0.7976707453866649 1.0 0.9379942937156972 72 Q9Y282,O75312,Q9H6U6,O60488,Q15154,Q9NR31,P00367,P22059,Q9H4A6,P51572,P27105,P31751,P50402,P55786 14 +Folic acid containing compound metabolic process 0.3373880462570462 0.254752559866756 0.798914218246928 1.0 0.9384139605155164 14 Q9H2D1 1 +Response to epidermal growth factor 0.3356063495069418 0.24546860814781 0.8060936118027608 1.0 0.9431834583566884 14 Q9UQB8,O95429 2 +Memory 0.4140639506740977 0.2438214041533869 0.8073691424083136 1.0 0.9435061315734384 7 O00264 1 +Positive regulation of oxidoreductase activity 0.394852206560272 0.2434638866360226 0.8076460578330134 1.0 0.9435061315734384 9 Q8WTV0 1 +Peptide transport 0.3054934766242196 0.2424731705189959 0.8084135434875293 1.0 0.9438758091900146 24 P00367,P22059,P40939,Q16836,Q13555 5 +Transport along microtubule 0.2763486532289956 0.2387772932853154 0.811278278335783 1.0 0.9453697110085594 46 A0AVF1,Q8TD16,P23246,Q5SNT2,Q14168,P07196,P05067,Q9NUL3,O60313,O75381 10 +Positive regulation of release of cytochrome c from mitochondria 0.4368729315396494 0.2358214791418121 0.8135712002086013 1.0 0.946225343035884 5 Q96A26 1 +Mitochondrial adp transmembrane transport 0.3833359188225014 0.2340998970185683 0.8149074258783542 1.0 0.947229924025978 3 P12236 1 +Regulation of endoplasmic reticulum unfolded protein response 0.4016660663601155 0.2326650017340733 0.8160215479961208 1.0 0.9478229932136256 8 P57088,O76024 2 +Regulation of calcineurin mediated signaling 0.4353242946134075 0.2312702670303159 0.8171048440547173 1.0 0.9483794067249982 5 Q8IWX8,P26599,P49841,P42345 4 +Inositol phosphate mediated signaling 0.4353242946134075 0.2312702670303159 0.8171048440547173 1.0 0.9483794067249982 5 Q8IWX8,P26599,P49841,P42345 4 +Calcineurin mediated signaling 0.4353242946134075 0.2312702670303159 0.8171048440547173 1.0 0.9483794067249982 5 Q8IWX8,P26599,P49841,P42345 4 +Negative regulation of canonical wnt signaling pathway 0.3388694530759196 0.2282986819123371 0.8194140491869042 1.0 0.9507886100220138 13 P48729,P50402,P25054 3 +Mitochondrial fission 0.3377223601759314 0.2227295035834806 0.8237460375529007 1.0 0.952492980105528 13 O60313,Q9UDX5 2 +Regulation of superoxide anion generation 0.3793482240937385 0.2220260415813037 0.8242936109730561 1.0 0.952492980105528 3 P08754,P04899 2 +Amyloid precursor protein biosynthetic process 0.3793482240937387 0.2220260415813037 0.8242936109730561 1.0 0.952492980105528 3 P35610,Q92542 2 +Astrocyte differentiation 0.3891797541211916 0.2219776081465068 0.8243313146122055 1.0 0.952492980105528 9 P05067 1 +Sodium ion transport 0.3193745605729474 0.221709027031304 0.8245404024393113 1.0 0.952492980105528 16 O43865,P08195,P50570,P27105 4 +Endothelial cell proliferation 0.325339804191554 0.221171100444612 0.8249592105644732 1.0 0.9527398682714796 15 Q8WTV0 1 +Vesicle targeting to from or within golgi 0.3525841530901638 0.2192092201260065 0.826487073524697 1.0 0.95397790909874 12 Q9HCU5,O15027 2 +Regulation of steroid metabolic process 0.3247504537254277 0.2180367655894899 0.8274004656789029 1.0 0.9544631644070573 15 Q15637,P16435,Q9UBM7 3 +Protein neddylation 0.4063532412064901 0.2179268818487552 0.8274860817929466 1.0 0.9544631644070573 7 Q92564 1 +Cellular response to chemical stress 0.265832019240714 0.2178183524842412 0.8275706446548197 1.0 0.9544631644070573 69 P11166,O95202,P23396,Q99720,P04062,Q8N0U8,Q969S3,Q8TED1,Q9NUL3,P09601,Q7Z2K6,P16615,Q15233,Q13546 14 +Centromere complex assembly 0.4245421245421264 0.2154654012957241 0.8294044843104824 1.0 0.9561148278555284 4 P49321,Q9NRZ9,Q7Z7K6 3 +Negative regulation of hormone metabolic process 0.3767850604174295 0.2144127319706797 0.830225213855408 1.0 0.9567095984919698 3 P05023,O60678 2 +Foam cell differentiation 0.3767850604174296 0.2144127319706797 0.830225213855408 1.0 0.9567095984919698 3 P35610,P42224 2 +Membrane raft organization 0.3865997883436075 0.2123856305542732 0.8318061952304021 1.0 0.9578281903258372 9 P50897,O15118 2 +Response to food 0.4282604500418303 0.2109254903025854 0.8329454131804643 1.0 0.9587882845520636 5 P53985,P80303 2 +Neural nucleus development 0.3099934944694422 0.2103050623247466 0.8334295844764639 1.0 0.9588182025551109 18 P00367,Q16352,O95487 3 +Negative regulation of dna binding transcription factor activity 0.305337703818075 0.2070091042987203 0.836002748302169 1.0 0.9607221771629172 21 O75381,O76024,P09601 3 +Positive regulation of cyclin dependent protein kinase activity 0.3738557305016478 0.2058550868680411 0.8369041094801206 1.0 0.9607850956714652 3 O75832,P14635 2 +Regulation of response to interferon gamma 0.3738557305016478 0.2058550868680411 0.8369041094801206 1.0 0.9607850956714652 3 Q16543,Q15648 2 +Transmembrane receptor protein serine threonine kinase signaling pathway 0.2765068973233526 0.2048068716367817 0.8377230180285324 1.0 0.961154906952953 41 Q96PK6,Q93062,Q92896,Q9UIQ6,P62942,Q8N0X7,P08670,Q8N1F7 8 +Membrane biogenesis 0.3089179314861665 0.2039304518785926 0.8384078479337773 1.0 0.9617256476024584 18 Q86XL3 1 +Regulation of cytoplasmic translational initiation 0.372391065543757 0.2016341571878875 0.8402027400630079 1.0 0.9625711194007708 3 P42345,Q9Y5A9 2 +Regulation of tor signaling 0.33323925758367 0.2012423540916888 0.840509075090397 1.0 0.9625711194007708 13 O75844,P04062 2 +Synaptic vesicle transport 0.3926202194677268 0.2010261157105446 0.840678153500227 1.0 0.9625711194007708 8 Q96A57 1 +Synaptic vesicle localization 0.3926202194677268 0.2010261157105446 0.840678153500227 1.0 0.9625711194007708 8 Q96A57 1 +Regulation of neuron differentiation 0.3083303234051192 0.2004611328762314 0.8411199524801987 1.0 0.962725808873416 18 Q8WUJ1 1 +Regulation of carbohydrate catabolic process 0.3261679503358328 0.1974671917801684 0.8434619531039738 1.0 0.9639140415091916 14 Q14108 1 +Small molecule metabolic process 0.2662679691902981 0.1973675261916785 0.8435399401165178 1.0 0.9639140415091916 440 P09960,Q6YP21,Q16850,P37268,P50897,Q9BQE5,P21796,O60725,P21912,Q8N0U8,O15118,P23786,P41440,Q9H2D1,Q9H773,Q9BY49,O43865,P51648,Q9P035,Q8WTV0,P11166,O95470,Q15392,Q15067,Q06136,Q99707,Q8N4Q0,Q9H0R6,P55263,P16435,P00367,Q10713,Q9BWD1,P05067,O14936,P07099,P38435,Q96EY8,Q14534,Q15125,Q9HCL2,Q9BRR6,Q00013,O75964,O15254,P43304,A1L0T0,Q15120,Q9UBX3,P22059,Q53GQ0,Q8TB61,Q8NCG7,P40939,Q9NUJ1,P04062,P16930,P31751,O60313,Q9BZF3,Q13126,Q8NCC3,Q15800,Q9UBM7,Q14739,O75844,Q14168,Q13011,P48449,P14618,O00767,Q16836,Q9H7Z7 73 +Regulation of ire1 mediated unfolded protein response 0.4076662462779818 0.1966712074987365 0.8440848430963572 1.0 0.9641147813424638 6 P57088 1 +Ire1 mediated unfolded protein response 0.3998007129498545 0.1966515514069689 0.8441002260209587 1.0 0.9641147813424638 7 P57088 1 +Positive regulation of transport 0.2530612672341762 0.1965543174004978 0.8441763225612493 1.0 0.9641147813424638 141 P50897,P41440,P61978,O43865,P55786,O60488,Q15154,Q9NR31,P00367,O76024,O14936,O75323,Q9Y282,Q8NBU5,Q96GC9,Q9H6U6,Q16625,P50570,P22059,Q9H4A6,P27105,P31751,P08183,Q9P2W9,O75312,Q07666,P51809,P51572,P50402 29 +Regulation of endoplasmic reticulum stress induced intrinsic apoptotic signaling pathway 0.3908037938065715 0.1948374699560076 0.8455201875950449 1.0 0.9649474164191404 8 O76024 1 +Oligodendrocyte development 0.3900298417462802 0.1922177173624938 0.8475716682244765 1.0 0.9660593560481596 8 Q9NR50,P49770,Q13144 3 +Regulation of animal organ morphogenesis 0.3893717133444204 0.1899981275172913 0.8493105978304825 1.0 0.9668453534553586 8 Q8TAA9 1 +Regulation of lipase activity 0.3609408775237567 0.1899614998401482 0.8493392998257889 1.0 0.9668453534553586 11 P50897,P16435 2 +Positive regulation of sodium ion transport 0.3976263531882296 0.1897447459939838 0.8495091554660792 1.0 0.966863393403924 7 O43865 1 +Mirna metabolic process 0.3890064240187033 0.1887693895751649 0.8502735640578905 1.0 0.9672472533397836 8 Q92841,Q9HAV4,Q92945,Q8TCS8,O95453 5 +Suppression of viral release by host 0.4049312292078176 0.1885280854292751 0.8504627012481052 1.0 0.9672472533397836 6 P14373,P19474,Q12899 3 +Ribonucleoprotein complex localization 0.3970892765626351 0.1880506910622314 0.8508369142301104 1.0 0.967322373693704 7 Q9ULX6,Q96ST2 2 +Regulation of cell aging 0.3696334348675241 0.1849093715529139 0.8533001203126758 1.0 0.9690552851143732 10 O75844,P67809 2 +Mating 0.4128831526300313 0.1842743343087605 0.8537982473823291 1.0 0.9691096360633272 4 P05067 1 +Vesicle docking involved in exocytosis 0.3586298699229188 0.1806132769395143 0.8566711337883406 1.0 0.9710064335015984 11 Q7Z6M1,P61006 2 +Antigen processing and presentation of peptide antigen 0.368134112202601 0.1792432929980461 0.8577466712446875 1.0 0.9718342541191388 10 P01889,Q9UIQ6 2 +T cell differentiation 0.2988721953024209 0.1775608815329485 0.859067848290856 1.0 0.97197101594261 22 O96005,P24390 2 +Response to alkaloid 0.3169039684506726 0.1771206428435867 0.8594136276295656 1.0 0.97197101594261 15 Q05086,Q13242 2 +Negative regulation of protein dephosphorylation 0.3429094109124703 0.1766220484453269 0.8598052742038733 1.0 0.97197101594261 12 P62942,O75663,Q15257,Q12972 4 +Regulation of urine volume 0.3177159590043845 0.1759453769633919 0.8603368557193201 1.0 0.97197101594261 2 P04899 1 +Response to hormone 0.2491391607983638 0.1739640199148022 0.8618937389653594 1.0 0.9726710216114554 159 P09960,Q8TBX8,O15118,P25054,P62993,P07196,Q9BSK2,O43865,Q9HCD5,P11166,O43823,P61960,Q15392,P16435,Q86X55,P09601,Q13153,Q96PK6,Q9H6U6,P49770,O15173,P40939,P04062,P31751,Q05086,P42785,Q99523,P61006,O43347,Q9UQB8,P14618,Q16836 32 +Positive regulation of epithelial cell migration 0.2951248702638682 0.1715740076186839 0.8637724433105203 1.0 0.9734090893687928 24 Q8WTV0,Q9NQC3 2 +Myotube differentiation 0.3203001626451824 0.1686919797220998 0.8660389276246767 1.0 0.9754498440892913 14 P41440,Q8IV08 2 +Negative regulation of cardiac muscle tissue growth 0.3603075796411571 0.1683164574656695 0.8663343273814466 1.0 0.9754498440892913 3 P49840,P11413 2 +Negative regulation of cell growth involved in cardiac muscle cell development 0.3603075796411571 0.1683164574656695 0.8663343273814466 1.0 0.9754498440892913 3 P49840,P11413 2 +Response to actinomycin d 0.3595752471622118 0.1663849586196409 0.8678540102472911 1.0 0.9763942279174884 3 P62829,O95251 2 +Stress induced premature senescence 0.3595752471622118 0.1663849586196406 0.8678540102472914 1.0 0.9763942279174884 3 Q16539,Q96EB6 2 +Benzene containing compound metabolic process 0.4117086231374888 0.1660281456002304 0.8681348005740332 1.0 0.9763942279174884 5 P16930 1 +Histone h2a k63 linked ubiquitination 0.3589854433501243 0.1648367706662222 0.8690724610959804 1.0 0.9763942279174884 3 O95071 1 +Dendritic cell cytokine production 0.4111396115793269 0.1645562637096268 0.869293258310325 1.0 0.9763942279174884 5 Q92499,Q9NY93,Q7Z434,Q9H2U1 4 +Positive regulation of myeloid leukocyte mediated immunity 0.4111396115793269 0.1645562637096268 0.869293258310325 1.0 0.9763942279174884 5 Q92499,Q9NY93,Q7Z434,Q9H2U1 4 +Myeloid dendritic cell cytokine production 0.4111396115793269 0.1645562637096268 0.869293258310325 1.0 0.9763942279174884 5 Q92499,Q9NY93,Q7Z434,Q9H2U1 4 +Positive regulation of dendritic cell cytokine production 0.4111396115793269 0.1645562637096268 0.869293258310325 1.0 0.9763942279174884 5 Q92499,Q9NY93,Q7Z434,Q9H2U1 4 +Cell death in response to hydrogen peroxide 0.3889871549241179 0.1630808111782528 0.8704548079921328 1.0 0.9763942279174884 7 Q99720 1 +Positive regulation of histone h4 acetylation 0.3125915080527038 0.1614715357708371 0.8717220283209177 1.0 0.9772626596069144 2 O95251 1 +Homophilic cell adhesion via plasma membrane adhesion molecules 0.4032967032967053 0.160134250639316 0.872775321194555 1.0 0.9775706452202348 4 Q14126,Q8WX93,P35613 3 +Cellular hyperosmotic response 0.387754982703263 0.1593813029801286 0.8733684686726504 1.0 0.977617951584137 7 P11166 1 +Diol biosynthetic process 0.3800090821206129 0.1592468590528713 0.8734743866899131 1.0 0.977617951584137 8 P04062,O15269 2 +Diol metabolic process 0.3800090821206129 0.1592468590528713 0.8734743866899131 1.0 0.977617951584137 8 P04062,O15269 2 +Cardiac chamber development 0.3133326000931088 0.1590222316432203 0.8736513583869479 1.0 0.977617951584137 15 P62942 1 +Positive regulation of protein catabolic process 0.2647693991500273 0.1578554943157763 0.8745706686536505 1.0 0.978011160991738 64 P53634,P48729,P25054,P46379,O43847,P51572,Q96J02,P04062,Q13190,Q9Y5A7 10 +Microtubule based transport 0.2676622549899617 0.1568916282203878 0.8753302578609783 1.0 0.9785119940974398 47 A0AVF1,Q8TD16,P23246,Q5SNT2,Q14168,P07196,P05067,Q9NUL3,O60313,O75381 10 +Negative regulation of neuron death 0.272947511255649 0.1561373750319082 0.8759247386107099 1.0 0.9790022269891466 37 P50897,O75312,P07196,O76024,P09601,Q01105,P04062,Q15233 8 +Liver morphogenesis 0.3544489198095936 0.153150575732979 0.8782795326113013 1.0 0.9804123232101262 3 Q15648,Q13618 2 +Negative regulation of mitochondrion organization 0.3373148460171872 0.1529378058850686 0.8784473218128106 1.0 0.98042529534948 12 P02545,O60313,Q99536,Q9H3K2 4 +Positive regulation of mitotic cell cycle spindle assembly checkpoint 0.4060095272993703 0.1515070575293467 0.879575744000306 1.0 0.9812280739482798 5 Q5JVF3,Q9Y6G9,Q13257,Q9Y6D9 4 +Peptidyl proline hydroxylation to 4 hydroxy l proline 0.4056430927079469 0.1505902986851831 0.8802989146438165 1.0 0.98179367314512 5 P13674,O15460,P07237,Q96HE7 4 +Positive regulation of cellular protein catabolic process 0.266782616044774 0.1473640153606736 0.8828447069691072 1.0 0.9831467796581466 45 P53634,P48729,P46379,P04062,P51572 5 +Positive regulation of cell killing 0.3903970109818047 0.147266645521244 0.8829215584123336 1.0 0.9831467796581466 6 P01889 1 +Regulation of leukocyte mediated cytotoxicity 0.3903970109818047 0.147266645521244 0.8829215584123336 1.0 0.9831467796581466 6 P01889 1 +Posttranslational protein targeting to membrane translocation 0.3973027148483009 0.145753017747919 0.884116366118259 1.0 0.9841281110798634 4 Q99442 1 +Negative regulation of epidermal growth factor activated receptor activity 0.3511534236543391 0.144909290354367 0.8847824912211986 1.0 0.9845204678990932 3 Q99816,Q9UNH7 2 +Neurogenesis 0.2479245971098917 0.143201734287182 0.8861308601766025 1.0 0.9847284254571004 219 O00264,Q32P28,P50897,O75306,P41440,Q9NR77,Q9NQC3,Q96G23,Q14108,Q99707,O14949,P42892,P54802,P05067,Q9NUL3,O75503,P08670,Q8WUJ1,Q96N66,O95487,Q8NCG7,P04062,P31751,Q05086,Q13555,P61006,Q9UQB8,Q9NZJ7,Q9BSJ2,Q8N0X7,Q8WWV3 31 +Cellular response to hydrogen peroxide 0.3048155341340136 0.1432016550014774 0.8861309227921197 1.0 0.9847284254571004 16 Q99720,Q13546 2 +Morphogenesis of a branching structure 0.3048124557334376 0.1431856775240098 0.8861435409453113 1.0 0.9847284254571004 16 P62993,Q9NQC3 2 +Regulation of dna binding transcription factor activity 0.2676818525363158 0.1405946073279597 0.888190208649591 1.0 0.9861678613999192 53 Q86UE4,P23396,P14373,P41440,O76024,P09601,P05067,O75381,Q13546 9 +Pinocytosis 0.3740319610617894 0.1404458584879079 0.8883077270505169 1.0 0.9861678613999192 8 Q9BZG1,P50897 2 +Regulation of dendritic spine morphogenesis 0.3470164674781284 0.1353434857475624 0.8923403047037075 1.0 0.9887416080495014 11 Q9UQB8,Q05086 2 +Leukocyte apoptotic process 0.2950691390993173 0.1351246372277688 0.892513331127194 1.0 0.9887416080495014 20 Q9HCL2,P24390 2 +Positive regulation of protein secretion 0.2973465452749731 0.1345435183042919 0.8929728012611036 1.0 0.988970633401923 17 P22059,P00367,Q9H4A6 3 +Positive regulation of cell population proliferation 0.2457749082920998 0.1344646960971327 0.8930351259565947 1.0 0.988970633401923 104 P11802,Q9BSK2,O60884,Q9NQC3,P23396,P43307,O95684,Q86X55,P09601,P48681,P00813,Q13153,P49366,Q9HCL2,P30825,P31751,P55209,Q52LJ0,Q01085 19 +Gene silencing by rna 0.2693992898957678 0.1326856692792797 0.8944419769044298 1.0 0.9899895572683998 39 P22626,O75844,P17844,O00571,Q01085,Q92600,Q14671,Q15631,P36507,Q9BWF3,Q5T280,Q13546 12 +Regulation of low density lipoprotein particle clearance 0.3847976483657127 0.1323042220295248 0.894743668037735 1.0 0.9899895572683998 6 P61978 1 +Regulation of rna export from nucleus 0.3459128649086019 0.1311952909887857 0.8956208210081191 1.0 0.9907854650729464 11 Q9ULX6,Q07666,Q96ST2 3 +Vesicle targeting 0.2942185463623785 0.1301594306244242 0.8964402911372436 1.0 0.9908470987011702 20 Q9HCU5,O15027,O95772 3 +Regulation of dendritic spine development 0.3315569624344538 0.1293270769084563 0.8970988470671439 1.0 0.9911979165588752 12 Q9UQB8,Q05086 2 +Positive regulation of isotype switching to iga isotypes 0.2997803806734912 0.1280928664882893 0.8980754812620289 1.0 0.9919278450673852 2 O96028 1 +Interleukin 2 production 0.3687755707432097 0.124466048048261 0.90094628103793 1.0 0.9944474548288847 8 P14373 1 +Response to xenobiotic stimulus 0.2653489867461595 0.1232134864603856 0.9019380462944568 1.0 0.9944474548288847 57 P27544,P16435,O15118,Q96K76,P17812,P09601,O43169,P40939,P07099,Q16836,P08183 11 +Regulation of phosphatase activity 0.294759892839439 0.1231350423501535 0.90200016263562 1.0 0.9944474548288847 18 P62942,O95429 2 +Response to interleukin 4 0.3744041070773765 0.121013120913341 0.9036806425873498 1.0 0.9956184542555938 7 P49327,P49736,P39023,P11802,P33993,P12268 6 +Regulation of dna helicase activity 0.340900768949103 0.120621836461397 0.9039905721342404 1.0 0.9956184542555938 3 P49736,P33993 2 +Positive regulation of rna splicing 0.2895294862103568 0.119262802310238 0.9050671525713558 1.0 0.9956184542555938 22 P98179,Q13595,O75312,P38159 4 +Inclusion body assembly 0.3736707004033782 0.1189984722595059 0.905276566142204 1.0 0.9956184542555938 7 P0DMV9,P62195,P55072,Q9UL15,P62333,P54652 6 +Regulation of cellular response to heat 0.3736707004033781 0.1189984722595059 0.905276566142204 1.0 0.9956184542555938 7 Q99543,Q9UHD1,Q96EB6,Q99615,P49841,P42345 6 +Hyperosmotic response 0.3666296254454151 0.1180944038073829 0.9059928575395448 1.0 0.99594171942449 8 P11166 1 +Pyrimidine nucleotide metabolic process 0.2995762426277048 0.1164183476702825 0.9073209949258938 1.0 0.9965292522996434 16 P04818,Q9H773,P17812,P13051 4 +Neural precursor cell proliferation 0.2890164158493015 0.1161476838456191 0.907535498269444 1.0 0.9965904946887476 22 P48681,Q8NCG7,Q15154,O75306 4 +Blastocyst development 0.2835124018809236 0.1156254158177358 0.9079494190935482 1.0 0.9967990777985236 27 Q8IWS0,Q9NQC3,O75312,P31350 4 +Deoxyribonucleotide biosynthetic process 0.3657496204059013 0.1155073493514871 0.908042995528792 1.0 0.9967990777985236 8 P55263 1 +Adp transport 0.3830857160954475 0.1138935130264236 0.9093222079607216 1.0 0.9976652963826916 4 P12236 1 +Glutamine family amino acid metabolic process 0.2862453136102215 0.1136444910065483 0.9095196170710768 1.0 0.9976652963826916 24 P00367 1 +Intraciliary transport 0.3900807175835391 0.1135826587534847 0.9095686346872656 1.0 0.9976652963826916 5 A0AVF1 1 +Neuron projection organization 0.2913352805369333 0.1135094675010818 0.909626657613018 1.0 0.9976652963826916 20 P05067,Q9UQB8,Q05086 3 +Negative regulation of intrinsic apoptotic signaling pathway in response to dna damage 0.3715335785138137 0.1131842481896272 0.909884483537822 1.0 0.9977737620350128 7 Q96K76 1 +Receptor internalization 0.2922585915865314 0.1095088286677806 0.9127989196203656 1.0 0.9992243447910472 18 P62993,P41440,Q8NBU5 3 +Positive regulation of mrna metabolic process 0.2628745847945649 0.1067141128405838 0.9150157861158256 1.0 1.0 59 Q969T7,Q96EP5,O60506,O95453,Q14103,P38159,P67809,Q14671,Q13595,P62995,P98179,Q92945,Q9NPI6 13 +N terminal protein amino acid acetylation 0.3739455949573625 0.1048404013022643 0.916502451080158 1.0 1.0 6 Q5VZE5,Q86UY6,P41227,Q9GZZ1 4 +Regulation of inclusion body assembly 0.3735337243401765 0.103838607907416 0.9172974273838248 1.0 1.0 6 P0DMV9,P62195,Q9UL15,P62333,P54652 5 +Positive regulation of focal adhesion assembly 0.3780219780219799 0.1033237026406258 0.9177060643073828 1.0 1.0 4 Q9Y2S7,P60903,Q96AC1 3 +Lipophagy 0.3848460067554141 0.1019957711780303 0.9187600316907774 1.0 1.0 5 O15269 1 +Reactive oxygen species biosynthetic process 0.3462742056742115 0.1018588566003904 0.9188687077222744 1.0 1.0 10 Q9BSK2,Q15067,O75027 3 +Regulation of rrna processing 0.3832905826309934 0.0986377388590919 0.92142590483986 1.0 1.0 5 Q15061,Q9Y5A9,Q9H583,Q8TED0 4 +Regulation of epithelial cell migration 0.2660306997406453 0.097426171453718 0.9223879617733356 1.0 1.0 35 P42785,Q8WTV0,Q9NQC3 3 +Positive regulation of t cell mediated immunity 0.3817782003125948 0.0954100714024244 0.9239891167513604 1.0 1.0 5 P01889 1 +Regulation of cysteine type endopeptidase activity 0.2610313285292333 0.0950013170424309 0.9243137808051792 1.0 1.0 46 P23396,Q15392,Q9NZJ7,P16435,Q96A26,P51572 6 +Regulation of lipoprotein particle clearance 0.3619792243372929 0.0882314264986465 0.9296927399767134 1.0 1.0 7 P61978 1 +Tor signaling 0.2880544898769306 0.0870809461489171 0.9306071706153064 1.0 1.0 18 O75844,P04062,Q9H4A6,P49840 4 +Meiosis ii cell cycle process 0.3695970695970715 0.0866541503286564 0.9309464220000652 1.0 1.0 4 O43683,O60566,P30153 3 +Ossification 0.2622866302580094 0.0861297764145893 0.9313632534138758 1.0 1.0 55 Q96A33,Q15125,O60506,O75844 4 +Cerebral cortex development 0.2817848280935569 0.0856335771064738 0.9317577058173931 1.0 1.0 24 P11166,Q9NQC3,Q96N66,P07196,P62995 5 +Nucleobase containing compound transport 0.2452055867322718 0.0832084886050468 0.9336857632179552 1.0 1.0 97 P41440,Q9H2D1,P67809,Q9BSK2,Q92945,Q99567,Q13546,P84103,P09651,Q8TD16,P22626,P12236,P51991,Q8TB61,Q8N1F7,Q8NFH4,Q9ULX6,Q5JVF3,Q07955,Q07666,Q9BTX1,Q96ST2 22 +Microtubule nucleation 0.3064549970359144 0.0831466922655985 0.9337348992945192 1.0 1.0 13 Q13153,Q96P70,Q96CW5,Q9BSJ2 4 +Regulation of glycoprotein metabolic process 0.3541308562194476 0.0827850514827294 0.9340224555121296 1.0 1.0 8 P35610,O14734 2 +Negative regulation of anoikis 0.3225924569754669 0.0824088258719687 0.934321617893183 1.0 1.0 3 P05556,Q07820 2 +Negative regulation of cell population proliferation 0.2472018321735071 0.0803797963371311 0.9359351950922776 1.0 1.0 89 Q32P28,P98175,P25054,Q9NNW5,Q96DY7,Q9NR77,Q15637,Q96G23,Q15392,O15164,P09493,Q13363,P09601,P05067,O14936,Q13153,Q96J02,P57105,Q01085,P50402 20 +Energy derivation by oxidation of organic compounds 0.2446113264692235 0.078951497842135 0.9370712016891783 1.0 1.0 117 P13073,O95168,P14406,P21912,O75306,O96000,Q9Y6M9,Q9BSK2,P46976,O14949,Q9NZ45,Q9UDW1,Q15070,O75964,P43304,P04062,P31751,O43676,Q13423,Q9H3K2,P06737 21 +Positive regulation of protein metabolic process 0.2471354489763735 0.0765168650234317 0.9390078969610448 1.0 1.0 295 Q9Y2R0,O60506,P25054,P46379,P41440,Q96P70,Q86XL3,Q567V2,Q13546,Q9BUN8,O43823,P23396,Q9BTE7,Q13432,Q14103,Q13363,P60228,P05067,Q13190,P08670,P62942,P22059,O43847,O95429,Q92564,Q96A26,P04062,P31751,Q05086,Q9ULX6,Q93062,Q9NZJ7,Q07666,P98179,P14618,P51572 36 +Negative regulation of intracellular transport 0.2958065798458106 0.0754712987062013 0.9398397327063313 1.0 1.0 15 P60604 1 +Neuromuscular junction development 0.3444118455293514 0.0734466315917258 0.9414507111250214 1.0 1.0 9 P05067 1 +Negative regulation of nuclear division 0.2856118250121782 0.0732157022369525 0.9416344713449822 1.0 1.0 17 Q5JVF3,Q96DY7,P25054 3 +Receptor clustering 0.3291726589422651 0.07176000936751 0.9427928986354276 1.0 1.0 11 Q14168,P57105 2 +Negative regulation of organ growth 0.3604395604395625 0.0698383001296429 0.9443223624900456 1.0 1.0 4 Q13043,P49840,P11413 3 +Positive regulation of telomere maintenance via telomere lengthening 0.2848535767176005 0.069414249138974 0.9446598871046628 1.0 1.0 17 P09651,O95453,P22626,Q96HR8 4 +Response to light stimulus 0.2602901945301613 0.0690644053626851 0.9449383537540768 1.0 1.0 53 P27544,Q9BRK5,Q13432,P05067,P31751 5 +Organelle localization 0.2429618379658979 0.0690384311909942 0.9449590287955304 1.0 1.0 160 Q96FF9,Q96A57,O75153,P07196,O95772,O43865,Q8IWA4,P16615,Q9HCU5,Q5SNT2,Q15154,Q9NR31,P09601,Q13190,Q96DB5,Q8TD16,O15400,Q96GC9,O60313,Q7Z6M1,P61006,Q9BUK6,Q9H0B6,O15027,Q9BZG1,P51809,O75381,Q9H267,Q9UEU0 29 +Skeletal system development 0.261280986969108 0.0690120242250294 0.9449800483725804 1.0 1.0 40 Q15125,Q32P28,O95470,O75844,P16435 5 +Negative regulation of helicase activity 0.3597069597069617 0.068551678581979 0.9453464832333468 1.0 1.0 4 Q96EB6,P49736,P33993 3 +Nik nf kappab signaling 0.2844416066344775 0.0673574097469832 0.9462971742458012 1.0 1.0 17 O43657,P05067 2 +Regulation of tumor necrosis factor mediated signaling pathway 0.3573352990365706 0.0668395598918972 0.9467094295707276 1.0 1.0 6 Q13546 1 +Rrna 3 end processing 0.3674695305769876 0.0667116806571226 0.9468112352096943 1.0 1.0 5 Q96B26,Q9NQT5,P63220 3 +Positive regulation of epithelial cell proliferation 0.2842546139479881 0.0664258098602533 0.9470388222806378 1.0 1.0 17 Q9NQC3 1 +Negative regulation of immune effector process 0.341925961701133 0.0664050417020148 0.9470553563672092 1.0 1.0 9 P09601 1 +Regulation of postsynapse organization 0.2976577455652677 0.0663687595401257 0.9470842416219836 1.0 1.0 14 Q9UQB8,Q05086 2 +P38mapk cascade 0.3578754578754599 0.0653730689792948 0.9478769660415836 1.0 1.0 4 P15311,Q99873,Q16539 3 +Nucleoside triphosphate metabolic process 0.2591010127589024 0.0647043391192248 0.948409407947234 1.0 1.0 43 Q9H773,P55263 2 +Histone lysine demethylation 0.3562920905801065 0.0646187353742606 0.9484775672137752 1.0 1.0 6 Q8IUF8 1 +Response to estrogen 0.3268207975261434 0.0639542467246739 0.9490066580072676 1.0 1.0 11 P04062,P09601 2 +Positive regulation of mrna splicing via spliceosome 0.2836548695582958 0.0634463191186457 0.9494111041988904 1.0 1.0 17 Q96EP5,P38159,Q13595,P98179,P62995 5 +Protein k63 linked ubiquitination 0.2969143173160465 0.0632645445022058 0.949555848571498 1.0 1.0 14 O95071,P14373,O00571,Q96J02,P19474 5 +Regulation of cell junction assembly 0.2753786799417175 0.0620972737875967 0.9504853680128064 1.0 1.0 27 P05067,P41440,Q9NUL3 3 +Membrane lipid catabolic process 0.326173900544789 0.0618315163927255 0.9506970050448966 1.0 1.0 11 P06865,P04062,P50897,O95470 4 +Maternal placenta development 0.3553113553113574 0.0610139595934542 0.9513480916210362 1.0 1.0 4 Q15363,P35613,Q96EP5 3 +Synaptic vesicle exocytosis 0.288007379571486 0.0603496845189783 0.9518771315027356 1.0 1.0 16 P16615 1 +Regulation of nik nf kappab signaling 0.2921419988732909 0.0591946745016953 0.9527970513384352 1.0 1.0 15 O43657,P05067 2 +Response to retinoic acid 0.3321781591912029 0.0575336498942412 0.9541201017527148 1.0 1.0 10 Q8TB36 1 +Positive regulation of mitotic cell cycle phase transition 0.2668803506268452 0.0573723354752372 0.9542485997856972 1.0 1.0 32 P14635,Q96FF9,P11802,Q9UKF6,Q96DY7,Q9UJX4,P31350,P05067 8 +Regulation of membrane potential 0.2585050992844287 0.0572485503411011 0.9543472039679088 1.0 1.0 52 Q9UQB8,O75844,Q14168,Q8N0X7,P05067,P04062,P31751,P16615 8 +Regulation of t cell mediated immunity 0.3523702075827702 0.0564463916472538 0.954986200651312 1.0 1.0 6 P01889 1 +Regulation of jun kinase activity 0.3517501965191594 0.0551800082550827 0.9559950557673168 1.0 1.0 6 P23396 1 +Negative regulation of signaling receptor activity 0.3512820512820531 0.0543776963473317 0.9566342482947932 1.0 1.0 4 Q99816,Q9UNH7,P30533 3 +Early endosome to golgi transport 0.3513203081601586 0.0543060571039021 0.956691323805694 1.0 1.0 6 Q13190 1 +Regulation of sodium ion transport 0.3114289834870835 0.05337388459323 0.9574340126208598 1.0 1.0 12 O43865,P50570,P27105 3 +Regulation of receptor internalization 0.3371454027400463 0.0532462323024814 0.9575357197860326 1.0 1.0 9 P41440 1 +Interferon gamma mediated signaling pathway 0.3598387687797683 0.0527727075195677 0.9579130074335134 1.0 1.0 5 P08238,Q16543,P42224,Q15648 4 +Histone h3 k36 methylation 0.3498427643807814 0.0520703130580185 0.9584726676127446 1.0 1.0 4 Q96ST2 1 +Negative regulation of cellular catabolic process 0.245815815016002 0.0517779161349544 0.9587056523140434 1.0 1.0 79 Q07820,O60506,O15118,P98175,P46379,Q9NNW5,P67809,Q08J23,Q96JB5,Q96HR8,Q99729,P35637,P49840,P08621,Q14103,Q13151,P09601,O95453,P10619,Q04323,Q92804,P07910 22 +Atp transport 0.3499686945205391 0.0515801598046042 0.958863228474882 1.0 1.0 6 P12236 1 +Regulation of type b pancreatic cell development 0.3039179787623581 0.0502310038839672 0.9599383052045942 1.0 1.0 3 P49841,P49840 2 +Negative regulation of leukocyte migration 0.348603911426724 0.0488614204739594 0.9610297341198324 1.0 1.0 6 P09601 1 +Enzyme linked receptor protein signaling pathway 0.2414608021571883 0.0474069923602408 0.9621888561904216 1.0 1.0 100 Q99523,Q9NQC3,O95470,Q93062,Q96PK6,Q9UQB8,Q8TBX8,Q92896,Q9UIQ6,P25054,P62942,Q8N0X7,P62993,Q9HCD5,Q13153,P31751,P08670,Q8N1F7 18 +Copii coated vesicle budding 0.2792564521117626 0.0469844915228721 0.9625255878496126 1.0 1.0 20 Q9HCU5,O95487,O15027 3 +Histone h3 k14 acetylation 0.3556267655058299 0.0454854794774141 0.9637203486182552 1.0 1.0 5 Q969T9,Q9HAF1,O95251 3 +Cardiolipin metabolic process 0.3468196859933338 0.0453582281700118 0.9638217757882506 1.0 1.0 6 P40939 1 +Regulation of cell killing 0.3434240912490457 0.0447540960828396 0.964303314422214 1.0 1.0 7 P01889 1 +Cellular response to unfolded protein 0.2741784830302446 0.0433225730848984 0.9654443973928744 1.0 1.0 25 Q9BUN8,Q7Z2K6,O76024 3 +Transcription coupled nucleotide excision repair 0.3425369456613586 0.0408669162050684 0.9674019924465064 1.0 1.0 4 P19447 1 +Negative regulation of multicellular organismal process 0.2435877115173009 0.0390363672156932 0.9688613938545771 1.0 1.0 91 Q16850,P14373,Q92945,P16615,Q9NQC3,Q96G23,O43823,Q9BWS9,Q15154,Q9UIQ6,P09601,P00813,P53634,O43847,Q96J02,P57105,Q4VCS5,P04062,Q8N0X7,P31483 20 +Trna catabolic process 0.3353158155744974 0.0356354814100981 0.9715730162054655 1.0 1.0 8 Q96B26,Q15024,Q9UPY3,Q9NQT5,Q08J23 5 +Cellular response to leucine starvation 0.2932991578176492 0.0349110866397267 0.9721506401430828 1.0 1.0 3 Q9P2J5,P42345 2 +Water homeostasis 0.3343027571775583 0.0333064416657547 0.9734302169048624 1.0 1.0 8 P04062 1 +Positive regulation of protein localization to membrane 0.2745122097701241 0.0322103339726869 0.9743043151379188 1.0 1.0 22 O00264,P27105,P31751 3 +Regulation of actin cytoskeleton reorganization 0.3366219659247785 0.0304940251756521 0.9756730583860308 1.0 1.0 7 Q9UQB8 1 +Positive regulation of posttranscriptional gene silencing 0.2886160613770081 0.0298059470774918 0.9762218157934834 1.0 1.0 14 P17844,Q01085,Q06787,Q14671,P36507,Q13546 6 +Neuron intrinsic apoptotic signaling pathway in response to oxidative stress 0.3336738253238297 0.0284025435144168 0.9773410955898764 1.0 1.0 4 Q15233 1 +Mitochondrial fragmentation involved in apoptotic process 0.3335756839359789 0.0282713455282747 0.9774457344173482 1.0 1.0 4 O00429 1 +Positive regulation of vascular associated smooth muscle cell proliferation 0.3333333333333351 0.027947998848524 0.9777036258327316 1.0 1.0 4 P08754,O95140,P04899 3 +Positive regulation of ubiquitin protein transferase activity 0.3150236007728995 0.0269229875157621 0.9785211587750168 1.0 1.0 11 Q92564 1 +Regulation of mitochondrial rna catabolic process 0.3434813821188818 0.0260805283100643 0.979193107937594 1.0 1.0 5 Q8TCS8,Q12849 2 +Negative regulation of steroid metabolic process 0.3311355311355331 0.025056755170893 0.9800096937161256 1.0 1.0 4 P19838,O94905,P05023 3 +Positive regulation of transmembrane receptor protein serine threonine kinase signaling pathway 0.3142431359645641 0.0246003143903382 0.9803737685293186 1.0 1.0 11 Q93062 1 +Regulation of biological process involved in symbiotic interaction 0.3259844841100823 0.0245156821250367 0.9804412749476576 1.0 1.0 9 P14373,Q9BTY2 2 +Camera type eye morphogenesis 0.334659016362746 0.0230211295505563 0.981633418470596 1.0 1.0 6 P54802 1 +In utero embryonic development 0.2431444868333236 0.0220428238658658 0.9824137953211474 1.0 1.0 76 Q8IWS0,Q9NQC3,O75312,Q8TCT9,O43772,P23786,P62993,P67809,P31350,Q96EK5,Q4VCS5 11 +Cytoskeleton dependent intracellular transport 0.2545769773871452 0.0211365496760834 0.9831367289757028 1.0 1.0 52 A0AVF1,Q8TD16,P23246,Q5SNT2,Q14168,P07196,P05067,Q9NUL3,O60313,O75381 10 +Multicellular organism reproduction 0.2387049694885446 0.0207749479374104 0.9834251820754858 1.0 1.0 102 A0AVF1,O95470,Q15067,Q9BQE5,P14373,P50570,Q9H9C1,Q07666,O60488,P00813,Q01085,Q9H6S0,P46379,Q9BTX1,P05067,Q8N2A8,P51572 17 +Polyadenylation dependent rna catabolic process 0.3395801011232874 0.0203485265556824 0.9837653451942464 1.0 1.0 5 Q8TCS8,Q96B26,Q9NQT5 3 +Mitochondrial genome maintenance 0.3271969177532558 0.017578451022959 0.9859751476141044 1.0 1.0 8 O60313,Q9BSK2 2 +Dna templated transcription termination 0.3270720258273386 0.0173115519282263 0.9861880698788754 1.0 1.0 8 O75844 1 +Regulation of viral induced cytoplasmic pattern recognition receptor signaling pathway 0.3264944616802497 0.0160815597372087 0.9871693248119566 1.0 1.0 8 O43657,Q14671 2 +Fibroblast proliferation 0.2996936448285574 0.0141803034137229 0.9886861340072182 1.0 1.0 12 O75844,P11802,P50402 3 +Positive regulation of cell substrate junction organization 0.328079178885631 0.0120472282701237 0.9903879350723392 1.0 1.0 6 P63000,Q96AC1,P60903,Q15555,Q9Y2S7 5 +Rhythmic process 0.2540513369648949 0.0111697442742449 0.9910880188103786 1.0 1.0 53 O00429,P23246,O95470,P04818,Q9NRV9,Q14103,P54802,Q15233,Q05086,Q9BQ04,Q9BWF3 11 +Positive regulation of cysteine type endopeptidase activity 0.2671586719687921 0.010955345009648 0.9912590742059296 1.0 1.0 27 P23396,Q9NZJ7,Q9P0J0,P51572,Q96A26,Q9BXK5 6 +Erbb signaling pathway 0.2725345931956288 0.0098413915096648 0.9921478324088072 1.0 1.0 18 Q9NQC3 1 +3 utr mediated mrna stabilization 0.3225686245519722 0.0079077242454346 0.9936906146700716 1.0 1.0 8 Q13151,P98175 2 +Male gamete generation 0.2505718050064081 0.0077410907027421 0.9938235649311844 1.0 1.0 64 Q15067,P14373,Q9H9C1,Q07666,P46379,Q9BTX1,A0AVF1,P51572 8 +Regulation of lymphocyte activation 0.2517345186819296 0.0072281366364291 0.9942328315930042 1.0 1.0 50 P49366,Q9HCL2,P23396,P30825,Q96J02,P00813,O96005 7 +B cell proliferation 0.3213621519086688 0.0054611201854969 0.9956426781779876 1.0 1.0 8 P17812 1 +Response to tumor necrosis factor 0.2574740367871097 0.0045211983791826 0.996392617906818 1.0 1.0 33 P23396,Q8TCT8,O95429,P04062,Q9Y5A7,Q13546 6 +Protein containing complex localization 0.2530500350532859 0.0005692235573661 0.9995458253364587 1.0 1.0 38 O15400,P23246,P61006,Q15154,Q14168,Q9BTX1,A0AVF1,Q9NUL3 8 diff --git a/msigdb_gobp/selections.json b/msigdb_gobp/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..7b7352778712d300635ca9c4aaf3e7e4cb9fc3e0 --- /dev/null +++ b/msigdb_gobp/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["10 formyltetrahydrofolate metabolic process", "2 oxoglutarate metabolic process", "2fe 2s cluster assembly", "3 phosphoadenosine 5 phosphosulfate biosynthetic process", "3 phosphoadenosine 5 phosphosulfate metabolic process", "3 utr mediated mrna destabilization", "3 utr mediated mrna stabilization", "5 phosphoribose 1 diphosphate metabolic process", "5s class rrna transcription by rna polymerase iii", "Abscission", "Acetyl coa biosynthetic process", "Acetyl coa biosynthetic process from pyruvate", "Acetyl coa metabolic process", "Acid secretion", "Acidic amino acid transport", "Acrosome assembly", "Actin crosslink formation", "Actin cytoskeleton reorganization", "Actin filament based movement", "Actin filament based process", "Actin filament based transport", "Actin filament bundle organization", "Actin filament depolymerization", "Actin filament network formation", "Actin filament organization", "Actin filament polymerization", "Actin filament reorganization", "Actin filament severing", "Actin mediated cell contraction", "Actin modification", "Actin myosin filament sliding", "Actin nucleation", "Actin polymerization dependent cell motility", "Actin polymerization or depolymerization", "Action potential", "Activated t cell proliferation", "Activation induced cell death of t cells", "Activation of adenylate cyclase activity", "Activation of cysteine type endopeptidase activity", "Activation of cysteine type endopeptidase activity involved in apoptotic process", "Activation of cysteine type endopeptidase activity involved in apoptotic process by cytochrome c", "Activation of gtpase activity", "Activation of immune response", "Activation of innate immune response", "Activation of nf kappab inducing kinase activity", "Activation of phospholipase c activity", "Activation of phospholipase d activity", "Activation of protein kinase activity", "Activation of protein kinase b activity", "Activation of protein kinase c activity", "Activin receptor signaling pathway", "Actomyosin contractile ring organization", "Actomyosin structure organization", "Acute inflammatory response", "Acute inflammatory response to antigenic stimulus", "Acute phase response", "Acyl carnitine transmembrane transport", "Acylglycerol homeostasis", "Adaptation of signaling pathway", "Adaptive immune response", "Adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains", "Adaptive thermogenesis", "Adenosine metabolic process", "Adenosine to inosine editing", "Adenylate cyclase activating adrenergic receptor signaling pathway", "Adenylate cyclase activating adrenergic receptor signaling pathway involved in heart process", "Adenylate cyclase activating dopamine receptor signaling pathway", "Adenylate cyclase activating g protein coupled receptor signaling pathway", "Adenylate cyclase inhibiting dopamine receptor signaling pathway", "Adenylate cyclase inhibiting g protein coupled receptor signaling pathway", "Adenylate cyclase modulating g protein coupled receptor signaling pathway", "Adherens junction assembly", "Adherens junction maintenance", "Adherens junction organization", "Adhesion of symbiont to host", "Adhesion of symbiont to host cell", "Adiponectin activated signaling pathway", "Adipose tissue development", "Adp biosynthetic process", "Adp metabolic process", "Adp transport", "Adrenergic receptor signaling pathway", "Adult behavior", "Adult locomotory behavior", "Aerobic respiration", "Aggrephagy", "Aggresome assembly", "Aging", "Alanine catabolic process", "Alanine transport", "Alcohol biosynthetic process", "Alcohol catabolic process", "Alcohol metabolic process", "Aldehyde biosynthetic process", "Aldehyde catabolic process", "Alditol biosynthetic process", "Alditol catabolic process", "Alditol metabolic process", "Alditol phosphate metabolic process", "Alkanesulfonate metabolic process", "Allantoin metabolic process", "Alpha amino acid catabolic process", "Alpha amino acid metabolic process", "Alpha beta t cell activation", "Alpha beta t cell differentiation", "Alpha beta t cell proliferation", "Alpha ketoglutarate transport", "Alpha linolenic acid metabolic process", "Alternative mrna splicing via spliceosome", "Ameboidal type cell migration", "Amelogenesis", "Amide biosynthetic process", "Amide transport", "Amine biosynthetic process", "Amine catabolic process", "Amine metabolic process", "Amine transport", "Amino acid activation", "Amino acid betaine biosynthetic process", "Amino acid betaine metabolic process", "Amino acid betaine transport", "Amino acid homeostasis", "Amino acid import", "Amino acid import across plasma membrane", "Amino acid neurotransmitter reuptake", "Amino acid salvage", "Amino acid transmembrane transport", "Amino acid transport", "Amino sugar biosynthetic process", "Amino sugar catabolic process", "Amino sugar metabolic process", "Aminoacyl trna metabolism involved in translational fidelity", "Aminoglycan biosynthetic process", "Aminoglycan catabolic process", "Aminoglycan metabolic process", "Aminoglycoside antibiotic metabolic process", "Aminophospholipid transport", "Ammonium ion metabolic process", "Amp biosynthetic process", "Amp catabolic process", "Amp metabolic process", "Amp salvage", "Ampa glutamate receptor clustering", "Amygdala development", "Amyloid beta clearance", "Amyloid beta clearance by cellular catabolic process", "Amyloid beta clearance by transcytosis", "Amyloid beta formation", "Amyloid beta metabolic process", "Amyloid fibril formation", "Amyloid precursor protein biosynthetic process", "Amyloid precursor protein catabolic process", "Amyloid precursor protein metabolic process", "Anagen", "Anaphase promoting complex dependent catabolic process", "Anatomical structure formation involved in morphogenesis", "Anatomical structure homeostasis", "Anatomical structure maturation", "Androgen biosynthetic process", "Androgen catabolic process", "Androgen metabolic process", "Androgen receptor signaling pathway", "Angiogenesis involved in wound healing", "Angiotensin activated signaling pathway", "Animal organ formation", "Animal organ maturation", "Animal organ morphogenesis", "Animal organ regeneration", "Anion homeostasis", "Anion transmembrane transport", "Anion transport", "Anoikis", "Anterior head development", "Anterior posterior axis specification", "Anterior posterior pattern specification", "Anterograde axonal transport", "Anterograde axonal transport of mitochondrion", "Anterograde dendritic transport", "Anterograde dendritic transport of neurotransmitter receptor complex", "Anterograde neuronal dense core vesicle transport", "Antibacterial humoral response", "Antifungal innate immune response", "Antigen processing and presentation", "Antigen processing and presentation of endogenous antigen", "Antigen processing and presentation of endogenous peptide antigen", "Antigen processing and presentation of endogenous peptide antigen via mhc class i via er pathway", "Antigen processing and presentation of exogenous antigen", "Antigen processing and presentation of exogenous peptide antigen", "Antigen processing and presentation of exogenous peptide antigen via mhc class i", "Antigen processing and presentation of exogenous peptide antigen via mhc class ii", "Antigen processing and presentation of lipid antigen via mhc class ib", "Antigen processing and presentation of peptide antigen", "Antigen processing and presentation of peptide antigen via mhc class i", "Antigen processing and presentation of peptide or polysaccharide antigen via mhc class ii", "Antigen processing and presentation via mhc class ib", "Antigen receptor mediated signaling pathway", "Antimicrobial humoral immune response mediated by antimicrobial peptide", "Antimicrobial humoral response", "Antiviral innate immune response", "Aorta development", "Aorta morphogenesis", "Aortic valve morphogenesis", "Apical junction assembly", "Apical protein localization", "Apolipoprotein a i mediated signaling pathway", "Apoptotic cell clearance", "Apoptotic chromosome condensation", "Apoptotic dna fragmentation", "Apoptotic mitochondrial changes", "Apoptotic process involved in blood vessel morphogenesis", "Apoptotic process involved in development", "Apoptotic process involved in heart morphogenesis", "Apoptotic process involved in morphogenesis", "Apoptotic signaling pathway", "Appendage development", "Appendage morphogenesis", "Arachidonic acid metabolic process", "Arachidonic acid secretion", "Arf protein signal transduction", "Arginine catabolic process", "Arginine metabolic process", "Aromatic amino acid family catabolic process", "Aromatic amino acid family metabolic process", "Aromatic amino acid transport", "Arp2 3 complex mediated actin nucleation", "Artery development", "Artery morphogenesis", "Asparagine metabolic process", "Aspartate family amino acid biosynthetic process", "Aspartate family amino acid catabolic process", "Aspartate family amino acid metabolic process", "Aspartate metabolic process", "Aspartate transmembrane transport", "Associative learning", "Astral microtubule organization", "Astrocyte activation", "Astrocyte cell migration", "Astrocyte development", "Astrocyte differentiation", "Asymmetric cell division", "Asymmetric neuroblast division", "Atf6 mediated unfolded protein response", "Atp biosynthetic process", "Atp metabolic process", "Atp synthesis coupled electron transport", "Atp synthesis coupled proton transport", "Atp transport", "Atrial cardiac muscle cell membrane repolarization", "Atrial cardiac muscle cell to av node cell signaling", "Atrial septum development", "Atrial septum morphogenesis", "Attachment of gpi anchor to protein", "Attachment of mitotic spindle microtubules to kinetochore", "Attachment of spindle microtubules to kinetochore", "Auditory receptor cell development", "Auditory receptor cell morphogenesis", "Autonomic nervous system development", "Autophagic cell death", "Autophagosome lysosome fusion", "Autophagosome maturation", "Autophagosome membrane docking", "Autophagosome organization", "Autophagy of mitochondrion", "Autophagy of nucleus", "Autophagy of peroxisome", "Axial mesoderm development", "Axis elongation", "Axis specification", "Axo dendritic protein transport", "Axo dendritic transport", "Axon choice point recognition", "Axon development", "Axon ensheathment in central nervous system", "Axon extension", "Axon midline choice point recognition", "Axonal fasciculation", "Axonal transport", "Axonal transport of mitochondrion", "Axonemal dynein complex assembly", "Axoneme assembly", "Axonogenesis involved in innervation", "Azole transmembrane transport", "B cell activation", "B cell activation involved in immune response", "B cell apoptotic process", "B cell differentiation", "B cell homeostasis", "B cell lineage commitment", "B cell mediated immunity", "B cell proliferation", "B cell receptor signaling pathway", "Barbed end actin filament capping", "Base conversion or substitution editing", "Base excision repair", "Base excision repair ap site formation", "Base excision repair gap filling", "Basement membrane assembly", "Basement membrane organization", "Basic amino acid transport", "Behavior", "Behavioral response to ethanol", "Behavioral response to pain", "Benzene containing compound metabolic process", "Bergmann glial cell differentiation", "Bile acid and bile salt transport", "Bile acid biosynthetic process", "Bile acid metabolic process", "Bile acid secretion", "Binding of sperm to zona pellucida", "Biological adhesion", "Biological phase", "Biological process involved in interaction with host", "Biological process involved in interaction with symbiont", "Biological process involved in interspecies interaction between organisms", "Biological process involved in intraspecies interaction between organisms", "Biological process involved in symbiotic interaction", "Biomineralization", "Blastocyst development", "Blastocyst formation", "Blastocyst growth", "Blastoderm segmentation", "Bleb assembly", "Blood vessel endothelial cell migration", "Blood vessel endothelial cell proliferation involved in sprouting angiogenesis", "Blood vessel morphogenesis", "Blood vessel remodeling", "Body fluid secretion", "Body morphogenesis", "Bone cell development", "Bone development", "Bone growth", "Bone marrow development", "Bone maturation", "Bone mineralization", "Bone morphogenesis", "Bone remodeling", "Bone resorption", "Box c d snornp assembly", "Bradykinin catabolic process", "Brain derived neurotrophic factor receptor signaling pathway", "Brain morphogenesis", "Brainstem development", "Branch elongation of an epithelium", "Branched chain amino acid biosynthetic process", "Branched chain amino acid catabolic process", "Branched chain amino acid metabolic process", "Branched chain amino acid transport", "Branching involved in blood vessel morphogenesis", "Branching involved in labyrinthine layer morphogenesis", "Branching involved in mammary gland duct morphogenesis", "Branching morphogenesis of a nerve", "Branching morphogenesis of an epithelial tube", "Brown fat cell differentiation", "Bundle of his cell to purkinje myocyte communication", "C 5 methylation of cytosine", "C terminal protein amino acid modification", "C terminal protein lipidation", "C21 steroid hormone biosynthetic process", "C21 steroid hormone metabolic process", "C4 dicarboxylate transport", "Calcineurin mediated signaling", "Calcium import into the mitochondrion", "Calcium ion export", "Calcium ion export across plasma membrane", "Calcium ion import", "Calcium ion import into sarcoplasmic reticulum", "Calcium ion regulated exocytosis", "Calcium ion regulated exocytosis of neurotransmitter", "Calcium ion transmembrane transport", "Calcium ion transmembrane transport via high voltage gated calcium channel", "Calcium ion transport", "Calcium ion transport into cytosol", "Calcium mediated signaling", "Calcium mediated signaling using intracellular calcium source", "Calmodulin dependent kinase signaling pathway", "Camera type eye development", "Camera type eye morphogenesis", "Camera type eye photoreceptor cell differentiation", "Camp mediated signaling", "Cannabinoid signaling pathway", "Canonical wnt signaling pathway", "Canonical wnt signaling pathway involved in heart development", "Canonical wnt signaling pathway involved in osteoblast differentiation", "Canonical wnt signaling pathway involved in regulation of cell proliferation", "Cap dependent translational initiation", "Carbohydrate biosynthetic process", "Carbohydrate catabolic process", "Carbohydrate derivative biosynthetic process", "Carbohydrate derivative catabolic process", "Carbohydrate derivative metabolic process", "Carbohydrate derivative transport", "Carbohydrate homeostasis", "Carbohydrate import across plasma membrane", "Carbohydrate mediated signaling", "Carbohydrate metabolic process", "Carbohydrate phosphorylation", "Carbohydrate transmembrane transport", "Carbohydrate transport", "Carboxylic acid transport", "Cardiac atrium development", "Cardiac atrium morphogenesis", "Cardiac cell development", "Cardiac chamber development", "Cardiac chamber morphogenesis", "Cardiac conduction", "Cardiac conduction system development", "Cardiac epithelial to mesenchymal transition", "Cardiac left ventricle morphogenesis", "Cardiac muscle cell action potential", "Cardiac muscle cell action potential involved in contraction", "Cardiac muscle cell cardiac muscle cell adhesion", "Cardiac muscle cell contraction", "Cardiac muscle cell differentiation", "Cardiac muscle cell membrane repolarization", "Cardiac muscle cell proliferation", "Cardiac muscle contraction", "Cardiac muscle tissue development", "Cardiac muscle tissue morphogenesis", "Cardiac neural crest cell development involved in outflow tract morphogenesis", "Cardiac neural crest cell differentiation involved in heart development", "Cardiac neural crest cell migration involved in outflow tract morphogenesis", "Cardiac septum development", "Cardiac septum morphogenesis", "Cardiac ventricle development", "Cardiac ventricle morphogenesis", "Cardioblast differentiation", "Cardioblast proliferation", "Cardiocyte differentiation", "Cardiolipin acyl chain remodeling", "Cardiolipin biosynthetic process", "Cardiolipin metabolic process", "Carnitine metabolic process", "Carnitine transport", "Cartilage development", "Cartilage development involved in endochondral bone morphogenesis", "Catechol containing compound biosynthetic process", "Catechol containing compound catabolic process", "Catechol containing compound metabolic process", "Catecholamine uptake", "Catecholamine uptake involved in synaptic transmission", "Cation transmembrane transport", "Cation transport", "Caveola assembly", "Caveolin mediated endocytosis", "Cd4 positive alpha beta t cell activation", "Cd4 positive alpha beta t cell differentiation", "Cd4 positive or cd8 positive alpha beta t cell lineage commitment", "Cd40 signaling pathway", "Cd8 positive alpha beta t cell activation", "Cd8 positive alpha beta t cell proliferation", "Cdc42 protein signal transduction", "Cdp choline pathway", "Cdp diacylglycerol metabolic process", "Cell activation", "Cell activation involved in immune response", "Cell adhesion mediated by integrin", "Cell adhesion molecule production", "Cell aggregation", "Cell aging", "Cell cell adhesion", "Cell cell adhesion involved in gastrulation", "Cell cell adhesion mediated by cadherin", "Cell cell adhesion mediated by integrin", "Cell cell adhesion via plasma membrane adhesion molecules", "Cell cell junction assembly", "Cell cell junction maintenance", "Cell cell junction organization", "Cell cell recognition", "Cell cell signaling", "Cell cell signaling by wnt", "Cell cell signaling involved in cardiac conduction", "Cell chemotaxis", "Cell communication by electrical coupling", "Cell communication by electrical coupling involved in cardiac conduction", "Cell communication involved in cardiac conduction", "Cell cycle", "Cell cycle checkpoint signaling", "Cell cycle dna replication", "Cell cycle dna replication initiation", "Cell cycle g1 s phase transition", "Cell cycle g2 m phase transition", "Cell cycle phase transition", "Cell cycle process", "Cell death in response to hydrogen peroxide", "Cell death in response to oxidative stress", "Cell differentiation in hindbrain", "Cell differentiation in spinal cord", "Cell differentiation involved in embryonic placenta development", "Cell differentiation involved in kidney development", "Cell differentiation involved in metanephros development", "Cell differentiation involved in phenotypic switching", "Cell division", "Cell fate commitment", "Cell fate commitment involved in formation of primary germ layer", "Cell fate determination", "Cell fate specification", "Cell growth", "Cell junction assembly", "Cell junction disassembly", "Cell junction maintenance", "Cell junction organization", "Cell killing", "Cell matrix adhesion", "Cell maturation", "Cell migration", "Cell migration in hindbrain", "Cell migration involved in gastrulation", "Cell migration involved in heart development", "Cell migration involved in sprouting angiogenesis", "Cell morphogenesis", "Cell morphogenesis involved in differentiation", "Cell morphogenesis involved in neuron differentiation", "Cell motility involved in cerebral cortex radial glia guided migration", "Cell part morphogenesis", "Cell projection assembly", "Cell projection organization", "Cell proliferation in forebrain", "Cell proliferation in hindbrain", "Cell proliferation involved in heart morphogenesis", "Cell proliferation involved in kidney development", "Cell proliferation involved in metanephros development", "Cell recognition", "Cell redox homeostasis", "Cell substrate adhesion", "Cell substrate junction organization", "Cell surface receptor signaling pathway involved in cell cell signaling", "Cell surface receptor signaling pathway involved in heart development", "Cell volume homeostasis", "Cellular aldehyde metabolic process", "Cellular amide metabolic process", "Cellular amino acid biosynthetic process", "Cellular amino acid catabolic process", "Cellular amino acid metabolic process", "Cellular anion homeostasis", "Cellular carbohydrate biosynthetic process", "Cellular carbohydrate catabolic process", "Cellular carbohydrate metabolic process", "Cellular component assembly involved in morphogenesis", "Cellular component disassembly", "Cellular component disassembly involved in execution phase of apoptosis", "Cellular component maintenance", "Cellular component morphogenesis", "Cellular copper ion homeostasis", "Cellular defense response", "Cellular detoxification of aldehyde", "Cellular extravasation", "Cellular glucan metabolic process", "Cellular glucose homeostasis", "Cellular homeostasis", "Cellular hormone metabolic process", "Cellular hyperosmotic response", "Cellular hyperosmotic salinity response", "Cellular ion homeostasis", "Cellular iron ion homeostasis", "Cellular ketone metabolic process", "Cellular lipid catabolic process", "Cellular lipid metabolic process", "Cellular macromolecule biosynthetic process", "Cellular macromolecule localization", "Cellular metabolic compound salvage", "Cellular modified amino acid biosynthetic process", "Cellular modified amino acid catabolic process", "Cellular modified amino acid metabolic process", "Cellular monovalent inorganic anion homeostasis", "Cellular monovalent inorganic cation homeostasis", "Cellular nitrogen compound catabolic process", "Cellular oxidant detoxification", "Cellular pigmentation", "Cellular polysaccharide catabolic process", "Cellular potassium ion homeostasis", "Cellular process involved in reproduction in multicellular organism", "Cellular protein catabolic process", "Cellular respiration", "Cellular response to abiotic stimulus", "Cellular response to acid chemical", "Cellular response to acidic ph", "Cellular response to alcohol", "Cellular response to aldehyde", "Cellular response to alkaloid", "Cellular response to amyloid beta", "Cellular response to antibiotic", "Cellular response to arsenic containing substance", "Cellular response to atp", "Cellular response to biotic stimulus", "Cellular response to brain derived neurotrophic factor stimulus", "Cellular response to cadmium ion", "Cellular response to calcium ion", "Cellular response to camp", "Cellular response to carbohydrate stimulus", "Cellular response to chemical stress", "Cellular response to cold", "Cellular response to copper ion", "Cellular response to corticosteroid stimulus", "Cellular response to dexamethasone stimulus", "Cellular response to dna damage stimulus", "Cellular response to dsrna", "Cellular response to electrical stimulus", "Cellular response to endogenous stimulus", "Cellular response to epinephrine stimulus", "Cellular response to estradiol stimulus", "Cellular response to estrogen stimulus", "Cellular response to ethanol", "Cellular response to ether", "Cellular response to exogenous dsrna", "Cellular response to external stimulus", "Cellular response to extracellular stimulus", "Cellular response to fatty acid", "Cellular response to fluid shear stress", "Cellular response to follicle stimulating hormone stimulus", "Cellular response to gamma radiation", "Cellular response to glucose starvation", "Cellular response to gonadotropin stimulus", "Cellular response to growth hormone stimulus", "Cellular response to heat", "Cellular response to heparin", "Cellular response to histamine", "Cellular response to hormone stimulus", "Cellular response to hydrogen peroxide", "Cellular response to hyperoxia", "Cellular response to increased oxygen levels", "Cellular response to indole 3 methanol", "Cellular response to inorganic substance", "Cellular response to insulin like growth factor stimulus", "Cellular response to insulin stimulus", "Cellular response to interferon alpha", "Cellular response to interferon beta", "Cellular response to interferon gamma", "Cellular response to interleukin 1", "Cellular response to ionizing radiation", "Cellular response to iron ion", "Cellular response to ketone", "Cellular response to leptin stimulus", "Cellular response to leucine", "Cellular response to leucine starvation", "Cellular response to light intensity", "Cellular response to light stimulus", "Cellular response to lipid", "Cellular response to lipoprotein particle stimulus", "Cellular response to lithium ion", "Cellular response to low density lipoprotein particle stimulus", "Cellular response to magnesium ion", "Cellular response to manganese ion", "Cellular response to mechanical stimulus", "Cellular response to mineralocorticoid stimulus", "Cellular response to molecule of bacterial origin", "Cellular response to muramyl dipeptide", "Cellular response to nicotine", "Cellular response to nitrogen compound", "Cellular response to nitrogen starvation", "Cellular response to nitrosative stress", "Cellular response to nutrient", "Cellular response to organic cyclic compound", "Cellular response to osmotic stress", "Cellular response to oxidised low density lipoprotein particle stimulus", "Cellular response to oxygen containing compound", "Cellular response to oxygen glucose deprivation", "Cellular response to oxygen levels", "Cellular response to oxygen radical", "Cellular response to parathyroid hormone stimulus", "Cellular response to peptide", "Cellular response to peptide hormone stimulus", "Cellular response to peptidoglycan", "Cellular response to ph", "Cellular response to potassium ion", "Cellular response to prostaglandin e stimulus", "Cellular response to prostaglandin stimulus", "Cellular response to radiation", "Cellular response to reactive nitrogen species", "Cellular response to reactive oxygen species", "Cellular response to retinoic acid", "Cellular response to salt", "Cellular response to salt stress", "Cellular response to sodium arsenite", "Cellular response to starvation", "Cellular response to steroid hormone stimulus", "Cellular response to sterol depletion", "Cellular response to stress", "Cellular response to testosterone stimulus", "Cellular response to thyroid hormone stimulus", "Cellular response to topologically incorrect protein", "Cellular response to toxic substance", "Cellular response to unfolded protein", "Cellular response to uv", "Cellular response to uv a", "Cellular response to uv c", "Cellular response to vascular endothelial growth factor stimulus", "Cellular response to virus", "Cellular response to vitamin", "Cellular response to vitamin d", "Cellular response to water stimulus", "Cellular response to x ray", "Cellular response to xenobiotic stimulus", "Cellular response to zinc ion", "Cellular senescence", "Cellular sodium ion homeostasis", "Cellular sphingolipid homeostasis", "Cellular transition metal ion homeostasis", "Cellular triglyceride homeostasis", "Cellular trivalent inorganic anion homeostasis", "Cenp a containing chromatin organization", "Central nervous system development", "Central nervous system maturation", "Central nervous system myelin formation", "Central nervous system neuron axonogenesis", "Central nervous system neuron development", "Central nervous system neuron differentiation", "Central nervous system projection neuron axonogenesis", "Centriole assembly", "Centriole centriole cohesion", "Centriole elongation", "Centromere complex assembly", "Centromeric sister chromatid cohesion", "Centrosome duplication", "Centrosome separation", "Ceramide biosynthetic process", "Ceramide catabolic process", "Ceramide metabolic process", "Ceramide transport", "Cerebellar cortex development", "Cerebellar cortex formation", "Cerebellar cortex morphogenesis", "Cerebellar granular layer development", "Cerebellar granular layer formation", "Cerebellar granular layer morphogenesis", "Cerebellar purkinje cell layer development", "Cerebellar purkinje cell layer formation", "Cerebellar purkinje cell layer morphogenesis", "Cerebral cortex cell migration", "Cerebral cortex development", "Cerebral cortex neuron differentiation", "Cerebral cortex radially oriented cell migration", "Cerebral cortex regionalization", "Cerebral cortex tangential migration", "Cerebrospinal fluid circulation", "Cgmp mediated signaling", "Changes to dna methylation involved in embryo development", "Chaperone cofactor dependent protein refolding", "Chaperone mediated autophagy", "Chaperone mediated protein complex assembly", "Chaperone mediated protein folding", "Chemical homeostasis", "Chemical homeostasis within a tissue", "Chemical synaptic transmission postsynaptic", "Chemokine c c motif ligand 5 production", "Chemokine c x c motif ligand 2 production", "Chemokine production", "Chemosensory behavior", "Chloride transmembrane transport", "Chloride transport", "Cholesterol catabolic process", "Cholesterol efflux", "Cholesterol storage", "Choline metabolic process", "Chondrocyte development", "Chondrocyte development involved in endochondral bone morphogenesis", "Chondrocyte differentiation", "Chondrocyte differentiation involved in endochondral bone morphogenesis", "Chondrocyte proliferation", "Chondroitin sulfate biosynthetic process", "Chondroitin sulfate proteoglycan biosynthetic process", "Chondroitin sulfate proteoglycan metabolic process", "Chorion development", "Chromatin assembly or disassembly", "Chromatin disassembly", "Chromatin organization", "Chromatin remodeling", "Chromatin remodeling at centromere", "Chromosome attachment to the nuclear envelope", "Chromosome condensation", "Chromosome localization", "Chromosome localization to nuclear envelope involved in homologous chromosome segregation", "Chromosome movement towards spindle pole", "Chromosome organization", "Chromosome organization involved in meiotic cell cycle", "Chromosome segregation", "Chromosome separation", "Cilium movement", "Cilium or flagellum dependent cell motility", "Cilium organization", "Circadian regulation of gene expression", "Circadian rhythm", "Circulatory system development", "Circulatory system process", "Citrate metabolic process", "Citrulline biosynthetic process", "Citrulline metabolic process", "Clathrin coat assembly", "Clathrin dependent endocytosis", "Cleavage furrow formation", "Cleavage involved in rrna processing", "Cobalamin metabolic process", "Cochlea development", "Cochlea morphogenesis", "Coenzyme a biosynthetic process", "Coenzyme a metabolic process", "Cognition", "Cohesin loading", "Collagen biosynthetic process", "Collagen catabolic process", "Collagen fibril organization", "Collagen metabolic process", "Collateral sprouting", "Collateral sprouting in absence of injury", "Collecting duct development", "Columnar cuboidal epithelial cell development", "Columnar cuboidal epithelial cell differentiation", "Columnar cuboidal epithelial cell maturation", "Common partner smad protein phosphorylation", "Complement activation", "Complement dependent cytotoxicity", "Connective tissue development", "Connective tissue replacement", "Constitutive heterochromatin assembly", "Constitutive secretory pathway", "Convergent extension", "Convergent extension involved in axis elongation", "Cop9 signalosome assembly", "Copi coated vesicle budding", "Copii coated vesicle budding", "Copii coated vesicle cargo loading", "Copper ion homeostasis", "Copper ion transport", "Copulation", "Coronary artery morphogenesis", "Coronary vasculature development", "Coronary vasculature morphogenesis", "Corpus callosum development", "Corpus callosum morphogenesis", "Cortical actin cytoskeleton organization", "Cortical cytoskeleton organization", "Corticospinal tract morphogenesis", "Corticosteroid receptor signaling pathway", "Corticotropin secretion", "Cotranslational protein targeting to membrane", "Cranial ganglion development", "Cranial nerve development", "Cranial skeletal system development", "Crd mediated mrna stabilization", "Cristae formation", "Cyclic gmp amp transmembrane import across plasma membrane", "Cyclic nucleotide catabolic process", "Cyclic nucleotide mediated signaling", "Cyclic nucleotide metabolic process", "Cyclooxygenase pathway", "Cysteine metabolic process", "Cytochrome complex assembly", "Cytokine mediated signaling pathway", "Cytokine production", "Cytokine production involved in immune response", "Cytokine production involved in inflammatory response", "Cytokinesis", "Cytokinetic process", "Cytoplasm organization", "Cytoplasmic microtubule organization", "Cytoplasmic pattern recognition receptor signaling pathway", "Cytoplasmic pattern recognition receptor signaling pathway in response to virus", "Cytoplasmic sequestering of nf kappab", "Cytoplasmic sequestering of protein", "Cytoplasmic sequestering of transcription factor", "Cytoplasmic translation", "Cytoplasmic translational elongation", "Cytoplasmic translational initiation", "Cytoskeleton dependent cytokinesis", "Cytoskeleton dependent intracellular transport", "Cytoskeleton organization", "Cytosolic calcium ion transport", "Cytosolic transport", "D amino acid transport", "Damp metabolic process", "De novo amp biosynthetic process", "De novo protein folding", "De novo pyrimidine nucleobase biosynthetic process", "Deadenylation dependent decapping of nuclear transcribed mrna", "Decidualization", "Dedifferentiation", "Defense response", "Defense response to bacterium", "Defense response to fungus", "Defense response to gram negative bacterium", "Defense response to gram positive bacterium", "Defense response to other organism", "Defense response to symbiont", "Defense response to tumor cell", "Definitive erythrocyte differentiation", "Definitive hemopoiesis", "Dehydroascorbic acid transport", "Delamination", "Demethylation", "Dendrite arborization", "Dendrite development", "Dendrite extension", "Dendrite morphogenesis", "Dendrite self avoidance", "Dendritic cell apoptotic process", "Dendritic cell chemotaxis", "Dendritic cell cytokine production", "Dendritic cell differentiation", "Dendritic cell migration", "Dendritic spine development", "Dendritic spine maintenance", "Dendritic spine morphogenesis", "Dendritic transport", "Dense core granule transport", "Dentate gyrus development", "Deoxyribonucleoside catabolic process", "Deoxyribonucleoside diphosphate metabolic process", "Deoxyribonucleoside metabolic process", "Deoxyribonucleoside monophosphate biosynthetic process", "Deoxyribonucleoside monophosphate catabolic process", "Deoxyribonucleoside monophosphate metabolic process", "Deoxyribonucleoside triphosphate biosynthetic process", "Deoxyribonucleoside triphosphate catabolic process", "Deoxyribonucleoside triphosphate metabolic process", "Deoxyribonucleotide biosynthetic process", "Deoxyribose phosphate catabolic process", "Deoxyribose phosphate metabolic process", "Dephosphorylation", "Dephosphorylation of rna polymerase ii c terminal domain", "Depyrimidination", "Dermatan sulfate biosynthetic process", "Dermatan sulfate metabolic process", "Dermatan sulfate proteoglycan metabolic process", "Desmosome organization", "Detection of abiotic stimulus", "Detection of biotic stimulus", "Detection of calcium ion", "Detection of cell density", "Detection of external biotic stimulus", "Detection of light stimulus", "Detection of mechanical stimulus", "Detection of molecule of bacterial origin", "Detection of muscle stretch", "Detection of other organism", "Detection of stimulus", "Detection of virus", "Detection of visible light", "Determination of adult lifespan", "Determination of dorsal ventral asymmetry", "Detoxification", "Detoxification of copper ion", "Detoxification of nitrogen compound", "Development of primary female sexual characteristics", "Development of primary sexual characteristics", "Development of secondary female sexual characteristics", "Development of secondary sexual characteristics", "Developmental cell growth", "Developmental growth", "Developmental growth involved in morphogenesis", "Developmental induction", "Developmental maturation", "Developmental pigmentation", "Developmental process involved in reproduction", "Diacylglycerol biosynthetic process", "Diacylglycerol metabolic process", "Diadenosine polyphosphate catabolic process", "Diadenosine polyphosphate metabolic process", "Diapedesis", "Diaphragm development", "Dicarboxylic acid biosynthetic process", "Dicarboxylic acid catabolic process", "Dicarboxylic acid metabolic process", "Dicarboxylic acid transport", "Diencephalon development", "Digestion", "Digestive system development", "Digestive system process", "Digestive tract morphogenesis", "Diol biosynthetic process", "Diol metabolic process", "Diphosphoinositol polyphosphate metabolic process", "Disaccharide metabolic process", "Diterpenoid biosynthetic process", "Divalent inorganic cation homeostasis", "Dna biosynthetic process", "Dna catabolic process", "Dna catabolic process endonucleolytic", "Dna catabolic process exonucleolytic", "Dna conformation change", "Dna damage induced protein phosphorylation", "Dna damage response signal transduction by p53 class mediator", "Dna damage response signal transduction by p53 class mediator resulting in cell cycle arrest", "Dna damage response signal transduction resulting in transcription", "Dna dealkylation", "Dna dealkylation involved in dna repair", "Dna deamination", "Dna dependent dna replication", "Dna dependent dna replication maintenance of fidelity", "Dna double strand break processing", "Dna endoreduplication", "Dna geometric change", "Dna integration", "Dna integrity checkpoint signaling", "Dna ligation", "Dna ligation involved in dna repair", "Dna metabolic process", "Dna methylation", "Dna methylation dependent heterochromatin assembly", "Dna methylation involved in gamete generation", "Dna methylation on cytosine", "Dna methylation or demethylation", "Dna modification", "Dna packaging", "Dna protection", "Dna recombination", "Dna repair", "Dna replication", "Dna replication checkpoint signaling", "Dna replication dependent chromatin organization", "Dna replication independent chromatin organization", "Dna replication initiation", "Dna replication synthesis of rna primer", "Dna strand elongation", "Dna strand elongation involved in dna replication", "Dna synthesis involved in dna repair", "Dna templated transcription elongation", "Dna templated transcription initiation", "Dna templated transcription termination", "Dna topological change", "Dna unwinding involved in dna replication", "Dolichyl diphosphate biosynthetic process", "Dopamine biosynthetic process", "Dopamine metabolic process", "Dopamine receptor signaling pathway", "Dopamine transport", "Dopaminergic neuron differentiation", "Dorsal root ganglion development", "Dorsal ventral axis specification", "Dorsal ventral neural tube patterning", "Dorsal ventral pattern formation", "Dosage compensation", "Double strand break repair", "Double strand break repair via break induced replication", "Double strand break repair via classical nonhomologous end joining", "Double strand break repair via nonhomologous end joining", "Dsrna processing", "Dtmp metabolic process", "Dttp metabolic process", "Dump metabolic process", "Ear development", "Ear morphogenesis", "Early endosome to golgi transport", "Eating behavior", "Ectoderm development", "Ectodermal cell differentiation", "Ectodermal placode development", "Ectopic germ cell programmed cell death", "Egg activation", "Electron transport chain", "Embryo development", "Embryo development ending in birth or egg hatching", "Embryo implantation", "Embryonic appendage morphogenesis", "Embryonic axis specification", "Embryonic body morphogenesis", "Embryonic brain development", "Embryonic camera type eye development", "Embryonic cleavage", "Embryonic cranial skeleton morphogenesis", "Embryonic digestive tract development", "Embryonic digit morphogenesis", "Embryonic forelimb morphogenesis", "Embryonic heart tube development", "Embryonic heart tube morphogenesis", "Embryonic hemopoiesis", "Embryonic hindlimb morphogenesis", "Embryonic morphogenesis", "Embryonic neurocranium morphogenesis", "Embryonic organ development", "Embryonic organ morphogenesis", "Embryonic pattern specification", "Embryonic placenta development", "Embryonic placenta morphogenesis", "Embryonic process involved in female pregnancy", "Embryonic skeletal joint development", "Embryonic skeletal joint morphogenesis", "Embryonic skeletal system development", "Embryonic skeletal system morphogenesis", "Embryonic viscerocranium morphogenesis", "Enamel mineralization", "Endocannabinoid signaling pathway", "Endocardium development", "Endochondral bone morphogenesis", "Endocrine hormone secretion", "Endocrine pancreas development", "Endocrine process", "Endocrine system development", "Endocytic recycling", "Endocytosis", "Endocytosis involved in viral entry into host cell", "Endoderm development", "Endoderm formation", "Endodermal cell differentiation", "Endodermal cell fate commitment", "Endomembrane system organization", "Endonucleolytic cleavage in 5 ets of tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna", "Endonucleolytic cleavage in its1 to separate ssu rrna from 5 8s rrna and lsu rrna from tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna", "Endonucleolytic cleavage involved in rrna processing", "Endoplasmic reticulum calcium ion homeostasis", "Endoplasmic reticulum localization", "Endoplasmic reticulum mannose trimming", "Endoplasmic reticulum membrane organization", "Endoplasmic reticulum organization", "Endoplasmic reticulum plasma membrane tethering", "Endoplasmic reticulum to cytosol transport", "Endoplasmic reticulum to golgi vesicle mediated transport", "Endoplasmic reticulum tubular network organization", "Endoplasmic reticulum unfolded protein response", "Endosomal lumen acidification", "Endosomal transport", "Endosomal vesicle fusion", "Endosome organization", "Endosome to lysosome transport", "Endosome to lysosome transport via multivesicular body sorting pathway", "Endosome to plasma membrane protein transport", "Endosome transport via multivesicular body sorting pathway", "Endothelial cell activation", "Endothelial cell apoptotic process", "Endothelial cell chemotaxis", "Endothelial cell development", "Endothelial cell migration", "Endothelial cell morphogenesis", "Endothelial cell proliferation", "Endothelin receptor signaling pathway", "Endothelium development", "Energy derivation by oxidation of organic compounds", "Energy homeostasis", "Energy reserve metabolic process", "Engulfment of apoptotic cell", "Ensheathment of neurons", "Enteroendocrine cell differentiation", "Entrainment of circadian clock", "Entry into host", "Entry of bacterium into host cell", "Enucleate erythrocyte differentiation", "Enzyme directed rrna pseudouridine synthesis", "Enzyme linked receptor protein signaling pathway", "Eosinophil activation", "Eosinophil chemotaxis", "Eosinophil mediated immunity", "Eosinophil migration", "Ephrin receptor signaling pathway", "Epiboly", "Epidermal cell differentiation", "Epidermis development", "Epidermis morphogenesis", "Epigenetic maintenance of chromatin in transcription competent conformation", "Epithelial cell apoptotic process", "Epithelial cell cell adhesion", "Epithelial cell development", "Epithelial cell differentiation", "Epithelial cell differentiation involved in kidney development", "Epithelial cell differentiation involved in prostate gland development", "Epithelial cell maturation", "Epithelial cell morphogenesis", "Epithelial cell proliferation", "Epithelial cell proliferation involved in lung morphogenesis", "Epithelial cell proliferation involved in prostate gland development", "Epithelial fluid transport", "Epithelial structure maintenance", "Epithelial to mesenchymal transition", "Epithelial tube branching involved in lung morphogenesis", "Epithelial tube formation", "Epithelial tube morphogenesis", "Epithelium development", "Epoxide metabolic process", "Er associated misfolded protein catabolic process", "Er nucleus signaling pathway", "Er overload response", "Erad pathway", "Erbb signaling pathway", "Erbb2 signaling pathway", "Erk1 and erk2 cascade", "Error free translesion synthesis", "Erythrocyte development", "Erythrocyte homeostasis", "Erythrocyte maturation", "Escrt complex disassembly", "Establishment of cell polarity", "Establishment of centrosome localization", "Establishment of endothelial barrier", "Establishment of endothelial intestinal barrier", "Establishment of epithelial cell apical basal polarity", "Establishment of epithelial cell polarity", "Establishment of golgi localization", "Establishment of lymphocyte polarity", "Establishment of meiotic spindle localization", "Establishment of mitochondrion localization", "Establishment of mitotic spindle localization", "Establishment of organelle localization", "Establishment of pigment granule localization", "Establishment of planar polarity involved in neural tube closure", "Establishment of planar polarity of embryonic epithelium", "Establishment of protein localization", "Establishment of protein localization to chromatin", "Establishment of protein localization to chromosome", "Establishment of protein localization to endoplasmic reticulum", "Establishment of protein localization to membrane", "Establishment of protein localization to mitochondrial membrane", "Establishment of protein localization to organelle", "Establishment of protein localization to plasma membrane", "Establishment of protein localization to telomere", "Establishment of protein localization to vacuole", "Establishment of rna localization", "Establishment of sister chromatid cohesion", "Establishment of spindle orientation", "Establishment of tissue polarity", "Establishment or maintenance of bipolar cell polarity", "Establishment or maintenance of cell polarity", "Establishment or maintenance of cytoskeleton polarity", "Establishment or maintenance of monopolar cell polarity", "Establishment or maintenance of transmembrane electrochemical gradient", "Estrogen biosynthetic process", "Estrogen metabolic process", "Estrous cycle", "Ethanol catabolic process", "Ethanol metabolic process", "Ethanol oxidation", "Ethanolamine containing compound metabolic process", "Ether biosynthetic process", "Ether metabolic process", "Excretion", "Execution phase of apoptosis", "Exit from mitosis", "Exocrine pancreas development", "Exocrine system development", "Exocyst localization", "Exocytic process", "Exocytosis", "Exonucleolytic catabolism of deadenylated mrna", "Exploration behavior", "Export across plasma membrane", "Export from cell", "External encapsulating structure organization", "Extracellular exosome assembly", "Extracellular matrix assembly", "Extracellular matrix disassembly", "Extracellular regulation of signal transduction", "Extracellular transport", "Extracellular vesicle biogenesis", "Extraembryonic membrane development", "Extrinsic apoptotic signaling pathway", "Extrinsic apoptotic signaling pathway via death domain receptors", "Eye morphogenesis", "Eye photoreceptor cell development", "Eye photoreceptor cell differentiation", "Eyelid development in camera type eye", "Face development", "Facultative heterochromatin assembly", "Farnesyl diphosphate metabolic process", "Fas signaling pathway", "Fat cell differentiation", "Fat cell proliferation", "Fat soluble vitamin biosynthetic process", "Fat soluble vitamin metabolic process", "Fatty acid alpha oxidation", "Fatty acid beta oxidation", "Fatty acid beta oxidation using acyl coa dehydrogenase", "Fatty acid beta oxidation using acyl coa oxidase", "Fatty acid biosynthetic process", "Fatty acid catabolic process", "Fatty acid derivative biosynthetic process", "Fatty acid derivative catabolic process", "Fatty acid derivative metabolic process", "Fatty acid elongation", "Fatty acid homeostasis", "Fatty acid metabolic process", "Fatty acid omega oxidation", "Fatty acid transmembrane transport", "Fatty acid transport", "Fatty acyl coa biosynthetic process", "Fatty acyl coa catabolic process", "Fatty acyl coa metabolic process", "Fc epsilon receptor signaling pathway", "Fc gamma receptor signaling pathway", "Fc receptor mediated stimulatory signaling pathway", "Fc receptor signaling pathway", "Fear response", "Feeding behavior", "Female gamete generation", "Female genitalia development", "Female meiosis chromosome segregation", "Female meiosis i", "Female meiotic nuclear division", "Female sex differentiation", "Fermentation", "Fertilization", "Fibroblast activation", "Fibroblast apoptotic process", "Fibroblast growth factor production", "Fibroblast growth factor receptor signaling pathway", "Fibroblast migration", "Fibroblast proliferation", "Filopodium assembly", "Flavin containing compound metabolic process", "Flavonoid metabolic process", "Fluid transport", "Foam cell differentiation", "Focal adhesion assembly", "Folate import across plasma membrane", "Folate transmembrane transport", "Folic acid containing compound biosynthetic process", "Folic acid containing compound catabolic process", "Folic acid containing compound metabolic process", "Folic acid metabolic process", "Folic acid transport", "Forebrain cell migration", "Forebrain development", "Forebrain generation of neurons", "Forebrain morphogenesis", "Forebrain neuron development", "Forebrain neuron differentiation", "Forebrain radial glial cell differentiation", "Forebrain regionalization", "Foregut morphogenesis", "Forelimb morphogenesis", "Formate metabolic process", "Formation of extrachromosomal circular dna", "Formation of primary germ layer", "Formation of translation preinitiation complex", "Free ubiquitin chain polymerization", "Fructose 1 6 bisphosphate metabolic process", "Fructose 2 6 bisphosphate metabolic process", "Fructose 6 phosphate metabolic process", "Fructose metabolic process", "Fucose metabolic process", "Fucosylation", "Fungiform papilla development", "Fungiform papilla morphogenesis", "G protein coupled acetylcholine receptor signaling pathway", "G protein coupled glutamate receptor signaling pathway", "G protein coupled opioid receptor signaling pathway", "G protein coupled purinergic receptor signaling pathway", "G protein coupled receptor internalization", "G protein coupled receptor signaling pathway", "G protein coupled receptor signaling pathway coupled to cyclic nucleotide second messenger", "G protein coupled receptor signaling pathway involved in heart process", "G quadruplex dna unwinding", "G0 to g1 transition", "G1 to g0 transition", "Galactose catabolic process", "Galactose metabolic process", "Gamete generation", "Gamma aminobutyric acid metabolic process", "Gamma aminobutyric acid secretion", "Gamma aminobutyric acid signaling pathway", "Gamma aminobutyric acid transport", "Ganglion development", "Ganglioside catabolic process", "Ganglioside metabolic process", "Gap junction assembly", "Gap junction mediated intercellular transport", "Gas homeostasis", "Gastrulation", "Gastrulation with mouth forming second", "Gdp mannose metabolic process", "Gdp metabolic process", "Gene silencing by rna", "Generation of precursor metabolites and energy", "Genitalia development", "Genitalia morphogenesis", "Genomic imprinting", "Germ cell development", "Germ cell migration", "Germ cell proliferation", "Germinal center b cell differentiation", "Germinal center formation", "Gland development", "Gland morphogenesis", "Glandular epithelial cell development", "Glandular epithelial cell differentiation", "Glial cell apoptotic process", "Glial cell development", "Glial cell differentiation", "Glial cell fate commitment", "Glial cell migration", "Glial cell proliferation", "Gliogenesis", "Glomerular epithelial cell development", "Glomerular epithelial cell differentiation", "Glomerular epithelium development", "Glomerular visceral epithelial cell migration", "Glomerulus development", "Glucan biosynthetic process", "Glucocorticoid biosynthetic process", "Glucocorticoid metabolic process", "Glucosamine containing compound catabolic process", "Glucosamine containing compound metabolic process", "Glucose 6 phosphate metabolic process", "Glucose catabolic process", "Glucose import", "Glucose import across plasma membrane", "Glucose import in response to insulin stimulus", "Glucose metabolic process", "Glucosylceramide metabolic process", "Glutamate biosynthetic process", "Glutamate catabolic process", "Glutamate homeostasis", "Glutamate metabolic process", "Glutamate receptor signaling pathway", "Glutamate reuptake", "Glutamate secretion", "Glutamate secretion neurotransmission", "Glutamine family amino acid biosynthetic process", "Glutamine family amino acid catabolic process", "Glutamine family amino acid metabolic process", "Glutamine metabolic process", "Glutamine transport", "Glutathione catabolic process", "Glutathione metabolic process", "Glycerol 3 phosphate metabolic process", "Glycerol ether metabolic process", "Glycerolipid biosynthetic process", "Glycerolipid catabolic process", "Glycerolipid metabolic process", "Glycerophospholipid biosynthetic process", "Glycerophospholipid catabolic process", "Glycerophospholipid metabolic process", "Glycine biosynthetic process", "Glycine metabolic process", "Glycolipid biosynthetic process", "Glycolipid catabolic process", "Glycolipid transport", "Glycolytic fermentation", "Glycolytic process through fructose 6 phosphate", "Glycoprotein biosynthetic process", "Glycoprotein catabolic process", "Glycoprotein metabolic process", "Glycosaminoglycan catabolic process", "Glycoside catabolic process", "Glycoside metabolic process", "Glycosphingolipid metabolic process", "Glycosyl compound biosynthetic process", "Glycosyl compound catabolic process", "Glycosyl compound metabolic process", "Glycosylation", "Glycosylceramide catabolic process", "Glycosylceramide metabolic process", "Glyoxylate metabolic process", "Gmp biosynthetic process", "Gmp metabolic process", "Gmp salvage", "Golgi disassembly", "Golgi localization", "Golgi organization", "Golgi ribbon formation", "Golgi to endosome transport", "Golgi to lysosome transport", "Golgi to plasma membrane protein transport", "Golgi to plasma membrane transport", "Golgi to vacuole transport", "Golgi vesicle budding", "Golgi vesicle transport", "Gpi anchor metabolic process", "Granulocyte activation", "Granulocyte chemotaxis", "Granulocyte differentiation", "Granulocyte migration", "Granzyme mediated programmed cell death signaling pathway", "Grooming behavior", "Growth", "Growth hormone receptor signaling pathway via jak stat", "Growth hormone secretion", "Growth plate cartilage chondrocyte differentiation", "Growth plate cartilage development", "Gtp biosynthetic process", "Gtp metabolic process", "Guanine metabolic process", "Guanine nucleotide transmembrane transport", "Guanine nucleotide transport", "Hair cell differentiation", "Hair cycle phase", "Hair follicle maturation", "Hair follicle placode formation", "Head development", "Head morphogenesis", "Heart development", "Heart formation", "Heart growth", "Heart morphogenesis", "Heart process", "Heart trabecula formation", "Heart trabecula morphogenesis", "Heart valve development", "Heart valve morphogenesis", "Heat acclimation", "Hematopoietic progenitor cell differentiation", "Hematopoietic stem cell differentiation", "Hematopoietic stem cell homeostasis", "Hematopoietic stem cell proliferation", "Heme transport", "Hemidesmosome assembly", "Hemoglobin biosynthetic process", "Hemoglobin metabolic process", "Hemostasis", "Heparan sulfate proteoglycan biosynthetic process", "Heparan sulfate proteoglycan biosynthetic process enzymatic modification", "Heparan sulfate proteoglycan biosynthetic process polysaccharide chain biosynthetic process", "Heparan sulfate proteoglycan metabolic process", "Hepatic stellate cell activation", "Hepaticobiliary system development", "Hepatocyte apoptotic process", "Hepatocyte differentiation", "Hepatocyte growth factor receptor signaling pathway", "Heterochromatin organization", "Heterotypic cell cell adhesion", "High density lipoprotein particle assembly", "High density lipoprotein particle clearance", "High density lipoprotein particle remodeling", "Hindbrain development", "Hindbrain maturation", "Hindbrain morphogenesis", "Hindbrain radial glia guided cell migration", "Hindlimb morphogenesis", "Hippo signaling", "Hippocampus development", "His purkinje system development", "Histamine production involved in inflammatory response", "Histamine secretion", "Histamine transport", "Histidine metabolic process", "Histone arginine methylation", "Histone deacetylation", "Histone deubiquitination", "Histone exchange", "Histone h2a acetylation", "Histone h2a k63 linked ubiquitination", "Histone h2a monoubiquitination", "Histone h2a phosphorylation", "Histone h2a ubiquitination", "Histone h2b ubiquitination", "Histone h3 acetylation", "Histone h3 deacetylation", "Histone h3 k14 acetylation", "Histone h3 k27 demethylation", "Histone h3 k27 methylation", "Histone h3 k27 trimethylation", "Histone h3 k36 demethylation", "Histone h3 k36 methylation", "Histone h3 k36 trimethylation", "Histone h3 k4 demethylation", "Histone h3 k4 methylation", "Histone h3 k4 trimethylation", "Histone h3 k9 acetylation", "Histone h3 k9 demethylation", "Histone h3 k9 dimethylation", "Histone h3 k9 methylation", "Histone h3 k9 modification", "Histone h3 k9 trimethylation", "Histone h4 acetylation", "Histone h4 deacetylation", "Histone h4 k12 acetylation", "Histone h4 k16 acetylation", "Histone h4 k20 methylation", "Histone h4 k20 trimethylation", "Histone h4 k5 acetylation", "Histone h4 r3 methylation", "Histone lysine demethylation", "Histone methylation", "Histone modification", "Histone monoubiquitination", "Histone mrna catabolic process", "Histone mrna metabolic process", "Histone phosphorylation", "Histone serine phosphorylation", "Histone threonine phosphorylation", "Histone ubiquitination", "Homeostasis of number of cells", "Homeostasis of number of cells within a tissue", "Homeostatic process", "Homocysteine metabolic process", "Homologous chromosome pairing at meiosis", "Homologous chromosome segregation", "Homologous recombination", "Homophilic cell adhesion via plasma membrane adhesion molecules", "Homotypic cell cell adhesion", "Hormone biosynthetic process", "Hormone catabolic process", "Hormone mediated signaling pathway", "Hormone metabolic process", "Hormone transport", "Humoral immune response", "Humoral immune response mediated by circulating immunoglobulin", "Hyaluronan biosynthetic process", "Hyaluronan metabolic process", "Hydrogen peroxide biosynthetic process", "Hydrogen peroxide catabolic process", "Hydrogen peroxide metabolic process", "Hydrogen sulfide biosynthetic process", "Hydrogen sulfide metabolic process", "Hyperosmotic response", "Hyperosmotic salinity response", "Hypothalamus cell differentiation", "Hypothalamus development", "Hypoxia inducible factor 1alpha signaling pathway", "I kappab kinase nf kappab signaling", "I kappab phosphorylation", "Icosanoid biosynthetic process", "Icosanoid metabolic process", "Icosanoid transport", "Immune effector process", "Immune response", "Immune response regulating cell surface receptor signaling pathway", "Immune response regulating signaling pathway", "Immune response to tumor cell", "Immune system development", "Immunoglobulin production", "Immunoglobulin production involved in immunoglobulin mediated immune response", "Immunoglobulin v d j recombination", "Immunological synapse formation", "Imp biosynthetic process", "Imp catabolic process", "Imp metabolic process", "Imp salvage", "Import across plasma membrane", "Import into cell", "Import into nucleus", "In utero embryonic development", "Inclusion body assembly", "Indolalkylamine metabolic process", "Indole containing compound biosynthetic process", "Indole containing compound metabolic process", "Inflammasome complex assembly", "Inflammatory cell apoptotic process", "Inflammatory response", "Inflammatory response to antigenic stimulus", "Inflammatory response to wounding", "Innate immune response", "Innate immune response activating signal transduction", "Innate immune response in mucosa", "Inner cell mass cell differentiation", "Inner cell mass cell proliferation", "Inner dynein arm assembly", "Inner ear auditory receptor cell differentiation", "Inner ear morphogenesis", "Inner ear receptor cell development", "Inner ear receptor cell stereocilium organization", "Inner mitochondrial membrane organization", "Innervation", "Inorganic anion transmembrane transport", "Inorganic anion transport", "Inorganic ion import across plasma membrane", "Inorganic ion transmembrane transport", "Inosine metabolic process", "Inositol lipid mediated signaling", "Inositol metabolic process", "Inositol phosphate catabolic process", "Inositol phosphate mediated signaling", "Inositol phosphate metabolic process", "Insulin like growth factor receptor signaling pathway", "Insulin metabolic process", "Insulin processing", "Insulin receptor signaling pathway", "Insulin secretion", "Insulin secretion involved in cellular response to glucose stimulus", "Integrated stress response signaling", "Integrin activation", "Integrin mediated signaling pathway", "Intercellular transport", "Interferon alpha production", "Interferon beta production", "Interferon gamma mediated signaling pathway", "Interferon gamma production", "Interleukin 1 alpha production", "Interleukin 1 mediated signaling pathway", "Interleukin 1 production", "Interleukin 10 production", "Interleukin 12 production", "Interleukin 17 production", "Interleukin 18 production", "Interleukin 2 production", "Interleukin 23 production", "Interleukin 27 mediated signaling pathway", "Interleukin 6 mediated signaling pathway", "Interleukin 6 production", "Interleukin 8 production", "Intermediate filament based process", "Intermediate filament bundle assembly", "Intermediate filament organization", "Intermembrane lipid transfer", "Interstrand cross link repair", "Intestinal absorption", "Intestinal epithelial cell development", "Intestinal epithelial cell differentiation", "Intestinal hexose absorption", "Intestinal lipid absorption", "Intra golgi vesicle mediated transport", "Intracellular distribution of mitochondria", "Intracellular estrogen receptor signaling pathway", "Intracellular lipid transport", "Intracellular mrna localization", "Intracellular protein transmembrane transport", "Intracellular protein transport", "Intracellular receptor signaling pathway", "Intracellular sterol transport", "Intracellular transport", "Intracellular transport of virus", "Intraciliary transport", "Intraciliary transport involved in cilium assembly", "Intrinsic apoptotic signaling pathway", "Intrinsic apoptotic signaling pathway by p53 class mediator", "Intrinsic apoptotic signaling pathway in response to dna damage", "Intrinsic apoptotic signaling pathway in response to dna damage by p53 class mediator", "Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress", "Intrinsic apoptotic signaling pathway in response to hydrogen peroxide", "Intrinsic apoptotic signaling pathway in response to hypoxia", "Intrinsic apoptotic signaling pathway in response to osmotic stress", "Intrinsic apoptotic signaling pathway in response to oxidative stress", "Ion homeostasis", "Ion transmembrane transport", "Ion transport", "Ire1 mediated unfolded protein response", "Ires dependent viral translational initiation", "Iron coordination entity transport", "Iron ion homeostasis", "Iron ion transmembrane transport", "Iron ion transport", "Iron sulfur cluster assembly", "Isocitrate metabolic process", "Isoleucine metabolic process", "Isopentenyl diphosphate biosynthetic process", "Isoprenoid biosynthetic process", "Isoprenoid metabolic process", "Isotype switching to iga isotypes", "Isotype switching to igg isotypes", "Jnk cascade", "Keratan sulfate metabolic process", "Keratinization", "Keratinocyte development", "Keratinocyte differentiation", "Keratinocyte migration", "Keratinocyte proliferation", "Ketone biosynthetic process", "Ketone body biosynthetic process", "Ketone body metabolic process", "Ketone catabolic process", "Kidney epithelium development", "Kidney mesenchyme development", "Kidney morphogenesis", "Killing by host of symbiont cells", "Killing of cells of another organism", "Kinetochore assembly", "Kinetochore organization", "Kynurenine metabolic process", "L alanine transport", "L alpha amino acid transmembrane transport", "L amino acid transport", "L arginine import across plasma membrane", "L arginine transmembrane transport", "L ascorbic acid metabolic process", "L aspartate transmembrane transport", "L glutamate import across plasma membrane", "L glutamate transmembrane transport", "L histidine transmembrane transport", "L kynurenine metabolic process", "L lysine transmembrane transport", "L methionine salvage from methylthioadenosine", "L phenylalanine metabolic process", "L proline biosynthetic process", "L serine biosynthetic process", "L serine catabolic process", "L serine metabolic process", "L serine transport", "Labyrinthine layer blood vessel development", "Labyrinthine layer development", "Labyrinthine layer morphogenesis", "Lacrimal gland development", "Lactate metabolic process", "Lactate transmembrane transport", "Lactation", "Lamellipodium assembly", "Lamellipodium morphogenesis", "Lamellipodium organization", "Late endosome to golgi transport", "Late endosome to lysosome transport", "Late endosome to vacuole transport", "Late endosome to vacuole transport via multivesicular body sorting pathway", "Late nucleophagy", "Lateral ventricle development", "Layer formation in cerebral cortex", "Learned vocalization behavior or vocal learning", "Learning", "Lens development in camera type eye", "Lens fiber cell development", "Lens fiber cell differentiation", "Lens morphogenesis in camera type eye", "Leptin mediated signaling pathway", "Leucine catabolic process", "Leucine import across plasma membrane", "Leucine metabolic process", "Leucine transport", "Leukocyte adhesion to vascular endothelial cell", "Leukocyte aggregation", "Leukocyte apoptotic process", "Leukocyte cell cell adhesion", "Leukocyte chemotaxis", "Leukocyte degranulation", "Leukocyte differentiation", "Leukocyte homeostasis", "Leukocyte mediated cytotoxicity", "Leukocyte mediated immunity", "Leukocyte migration", "Leukocyte proliferation", "Leukocyte tethering or rolling", "Leukotriene b4 metabolic process", "Leukotriene biosynthetic process", "Leukotriene metabolic process", "Leydig cell differentiation", "Ligand gated ion channel signaling pathway", "Limb joint morphogenesis", "Limbic system development", "Linoleic acid metabolic process", "Lipid biosynthetic process", "Lipid catabolic process", "Lipid digestion", "Lipid droplet formation", "Lipid droplet organization", "Lipid export from cell", "Lipid glycosylation", "Lipid homeostasis", "Lipid import into cell", "Lipid localization", "Lipid metabolic process", "Lipid modification", "Lipid oxidation", "Lipid phosphorylation", "Lipid storage", "Lipid translocation", "Lipid transport across blood brain barrier", "Lipophagy", "Lipopolysaccharide mediated signaling pathway", "Lipoprotein biosynthetic process", "Lipoprotein catabolic process", "Lipoprotein localization", "Lipoprotein metabolic process", "Liposaccharide metabolic process", "Lipoxin metabolic process", "Liver morphogenesis", "Liver regeneration", "Localization within membrane", "Locomotion", "Locomotion involved in locomotory behavior", "Locomotor rhythm", "Locomotory behavior", "Locomotory exploration behavior", "Long chain fatty acid biosynthetic process", "Long chain fatty acid import across plasma membrane", "Long chain fatty acid metabolic process", "Long chain fatty acid transport", "Long chain fatty acyl coa biosynthetic process", "Long chain fatty acyl coa metabolic process", "Long term memory", "Long term synaptic depression", "Long term synaptic potentiation", "Low density lipoprotein particle clearance", "Low density lipoprotein receptor particle metabolic process", "Lung alveolus development", "Lung associated mesenchyme development", "Lung cell differentiation", "Lung epithelium development", "Lung lobe development", "Lung morphogenesis", "Lung saccule development", "Lung secretory cell differentiation", "Luteinization", "Luteolysis", "Lymph vessel development", "Lymph vessel morphogenesis", "Lymphangiogenesis", "Lymphocyte activation", "Lymphocyte activation involved in immune response", "Lymphocyte aggregation", "Lymphocyte anergy", "Lymphocyte apoptotic process", "Lymphocyte chemotaxis", "Lymphocyte costimulation", "Lymphocyte homeostasis", "Lymphocyte mediated immunity", "Lymphocyte migration", "Lymphocyte migration into lymphoid organs", "Lymphoid progenitor cell differentiation", "Lysine catabolic process", "Lysine metabolic process", "Lysosomal lumen acidification", "Lysosomal membrane organization", "Lysosomal microautophagy", "Lysosomal protein catabolic process", "Lysosomal transport", "Lytic vacuole organization", "Macroautophagy", "Macromolecule catabolic process", "Macromolecule deacylation", "Macromolecule depalmitoylation", "Macrophage activation", "Macrophage apoptotic process", "Macrophage chemotaxis", "Macrophage cytokine production", "Macrophage differentiation", "Macrophage migration", "Macrophage proliferation", "Macropinocytosis", "Magnesium ion homeostasis", "Magnesium ion transport", "Maintenance of apical basal cell polarity", "Maintenance of blood brain barrier", "Maintenance of cell number", "Maintenance of cell polarity", "Maintenance of centrosome location", "Maintenance of dna methylation", "Maintenance of dna repeat elements", "Maintenance of gastrointestinal epithelium", "Maintenance of lens transparency", "Maintenance of location", "Maintenance of location in cell", "Maintenance of organelle location", "Maintenance of postsynaptic specialization structure", "Maintenance of presynaptic active zone structure", "Maintenance of protein localization in endoplasmic reticulum", "Maintenance of protein localization in organelle", "Maintenance of protein location", "Maintenance of protein location in cell", "Maintenance of protein location in mitochondrion", "Maintenance of protein location in nucleus", "Maintenance of sister chromatid cohesion", "Maintenance of synapse structure", "Malate metabolic process", "Male gamete generation", "Male genitalia development", "Male mating behavior", "Male meiosis i", "Male meiotic nuclear division", "Male sex determination", "Male sex differentiation", "Malonyl coa metabolic process", "Mammalian oogenesis stage", "Mammary gland alveolus development", "Mammary gland branching involved in pregnancy", "Mammary gland development", "Mammary gland duct morphogenesis", "Mammary gland epithelial cell differentiation", "Mammary gland epithelial cell proliferation", "Mammary gland epithelium development", "Mammary gland involution", "Mammary gland morphogenesis", "Manganese ion transmembrane transport", "Manganese ion transport", "Mannose metabolic process", "Mannosylation", "Mapk cascade", "Mast cell activation", "Mast cell activation involved in immune response", "Mast cell cytokine production", "Maternal placenta development", "Maternal process involved in female pregnancy", "Mating", "Mating behavior", "Maturation of 5 8s rrna", "Maturation of 5 8s rrna from tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna", "Maturation of lsu rrna", "Maturation of lsu rrna from tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna", "Maturation of ssu rrna", "Maturation of ssu rrna from tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna", "Mature b cell differentiation", "Mature ribosome assembly", "Mda 5 signaling pathway", "Mechanoreceptor differentiation", "Mechanosensory behavior", "Medium chain fatty acid biosynthetic process", "Medium chain fatty acid catabolic process", "Medium chain fatty acid metabolic process", "Medium chain fatty acyl coa metabolic process", "Megakaryocyte development", "Megakaryocyte differentiation", "Meiosis i cell cycle process", "Meiosis ii cell cycle process", "Meiotic cell cycle", "Meiotic cell cycle checkpoint signaling", "Meiotic cell cycle process", "Meiotic chromosome condensation", "Meiotic chromosome segregation", "Meiotic chromosome separation", "Meiotic cytokinesis", "Meiotic dna double strand break formation", "Meiotic sister chromatid cohesion centromeric", "Meiotic spindle assembly", "Meiotic spindle organization", "Membrane biogenesis", "Membrane depolarization", "Membrane depolarization during action potential", "Membrane depolarization during cardiac muscle cell action potential", "Membrane disassembly", "Membrane docking", "Membrane fission", "Membrane fusion", "Membrane hyperpolarization", "Membrane invagination", "Membrane lipid biosynthetic process", "Membrane lipid catabolic process", "Membrane lipid metabolic process", "Membrane organization", "Membrane protein ectodomain proteolysis", "Membrane protein intracellular domain proteolysis", "Membrane protein proteolysis", "Membrane raft assembly", "Membrane raft localization", "Membrane raft organization", "Membrane repolarization", "Membrane repolarization during action potential", "Membrane repolarization during atrial cardiac muscle cell action potential", "Membrane repolarization during cardiac muscle cell action potential", "Membrane to membrane docking", "Membranous septum morphogenesis", "Memory", "Mesenchymal cell development", "Mesenchymal cell differentiation", "Mesenchymal cell differentiation involved in kidney development", "Mesenchymal cell proliferation", "Mesenchymal cell proliferation involved in lung development", "Mesenchymal stem cell differentiation", "Mesenchymal stem cell proliferation", "Mesenchymal to epithelial transition", "Mesenchymal to epithelial transition involved in metanephros morphogenesis", "Mesenchyme development", "Mesenchyme morphogenesis", "Mesoderm development", "Mesoderm morphogenesis", "Mesodermal cell differentiation", "Mesonephric tubule morphogenesis", "Mesonephros development", "Metal ion export", "Metal ion homeostasis", "Metal ion transport", "Metanephric collecting duct development", "Metanephric epithelium development", "Metanephric mesenchymal cell differentiation", "Metanephric mesenchyme development", "Metanephric nephron development", "Metanephric nephron morphogenesis", "Metanephric nephron tubule epithelial cell differentiation", "Metanephric part of ureteric bud development", "Metanephric renal vesicle morphogenesis", "Metanephric tubule development", "Metanephros development", "Metanephros morphogenesis", "Metaphase anaphase transition of cell cycle", "Metaphase plate congression", "Metencephalon development", "Methionine biosynthetic process", "Methionine metabolic process", "Methylation", "Methylglyoxal metabolic process", "Methylguanosine cap decapping", "Mhc class i biosynthetic process", "Mhc class ii biosynthetic process", "Microglia differentiation", "Microglial cell activation", "Microglial cell proliferation", "Microtubule anchoring", "Microtubule anchoring at centrosome", "Microtubule anchoring at microtubule organizing center", "Microtubule based movement", "Microtubule based process", "Microtubule based transport", "Microtubule bundle formation", "Microtubule cytoskeleton organization", "Microtubule cytoskeleton organization involved in mitosis", "Microtubule depolymerization", "Microtubule nucleation", "Microtubule organizing center localization", "Microtubule organizing center organization", "Microtubule polymerization", "Microtubule polymerization or depolymerization", "Microvillus assembly", "Microvillus organization", "Midbody abscission", "Midbrain development", "Midbrain dopaminergic neuron differentiation", "Middle ear morphogenesis", "Minus end directed organelle transport along microtubule", "Mirna catabolic process", "Mirna loading onto risc involved in gene silencing by mirna", "Mirna metabolic process", "Mismatch repair", "Mitochondrial acetyl coa biosynthetic process from pyruvate", "Mitochondrial adp transmembrane transport", "Mitochondrial atp synthesis coupled proton transport", "Mitochondrial calcium ion homeostasis", "Mitochondrial calcium ion transmembrane transport", "Mitochondrial cytochrome c oxidase assembly", "Mitochondrial depolarization", "Mitochondrial dna metabolic process", "Mitochondrial dna repair", "Mitochondrial dna replication", "Mitochondrial electron transport cytochrome c to oxygen", "Mitochondrial electron transport nadh to ubiquinone", "Mitochondrial electron transport ubiquinol to cytochrome c", "Mitochondrial fission", "Mitochondrial fragmentation involved in apoptotic process", "Mitochondrial fusion", "Mitochondrial gene expression", "Mitochondrial genome maintenance", "Mitochondrial membrane organization", "Mitochondrial outer membrane permeabilization", "Mitochondrial outer membrane permeabilization involved in programmed cell death", "Mitochondrial protein catabolic process", "Mitochondrial protein processing", "Mitochondrial proton transporting atp synthase complex assembly", "Mitochondrial respirasome assembly", "Mitochondrial respiratory chain complex assembly", "Mitochondrial ribosome assembly", "Mitochondrial rna 3 end processing", "Mitochondrial rna catabolic process", "Mitochondrial rna metabolic process", "Mitochondrial rna modification", "Mitochondrial rna processing", "Mitochondrial transcription", "Mitochondrial translation", "Mitochondrial translational elongation", "Mitochondrial transmembrane transport", "Mitochondrial transport", "Mitochondrial trna processing", "Mitochondrion distribution", "Mitochondrion endoplasmic reticulum membrane tethering", "Mitochondrion localization", "Mitochondrion morphogenesis", "Mitochondrion organization", "Mitophagy", "Mitotic cell cycle", "Mitotic cell cycle checkpoint signaling", "Mitotic cell cycle phase transition", "Mitotic cell cycle process", "Mitotic chromosome condensation", "Mitotic cytokinesis", "Mitotic cytokinetic process", "Mitotic dna integrity checkpoint signaling", "Mitotic dna replication", "Mitotic dna replication checkpoint signaling", "Mitotic g1 s transition checkpoint signaling", "Mitotic g2 dna damage checkpoint signaling", "Mitotic g2 m transition checkpoint", "Mitotic intra s dna damage checkpoint signaling", "Mitotic metaphase plate congression", "Mitotic nuclear division", "Mitotic nuclear membrane disassembly", "Mitotic nuclear membrane organization", "Mitotic recombination", "Mitotic sister chromatid cohesion", "Mitotic sister chromatid segregation", "Mitotic spindle assembly", "Mitotic spindle midzone assembly", "Mitotic spindle organization", "Modification dependent macromolecule catabolic process", "Modification of postsynaptic actin cytoskeleton", "Modification of postsynaptic structure", "Modification of synaptic structure", "Modified amino acid transport", "Modulation by host of symbiont catalytic activity", "Modulation by host of symbiont process", "Modulation by host of viral genome replication", "Modulation by host of viral process", "Modulation of age related behavioral decline", "Modulation of excitatory postsynaptic potential", "Molting cycle", "Monoacylglycerol catabolic process", "Monoacylglycerol metabolic process", "Monoamine transport", "Monocarboxylic acid biosynthetic process", "Monocarboxylic acid catabolic process", "Monocarboxylic acid metabolic process", "Monocarboxylic acid transport", "Monocyte chemotaxis", "Monocyte differentiation", "Monocyte extravasation", "Mononuclear cell differentiation", "Mononuclear cell migration", "Monosaccharide biosynthetic process", "Monosaccharide catabolic process", "Monosaccharide metabolic process", "Monoubiquitinated protein deubiquitination", "Monovalent inorganic anion homeostasis", "Monovalent inorganic cation homeostasis", "Morphogenesis of a branching structure", "Morphogenesis of a polarized epithelium", "Morphogenesis of an endothelium", "Morphogenesis of an epithelial bud", "Morphogenesis of an epithelial fold", "Morphogenesis of an epithelial sheet", "Morphogenesis of an epithelium", "Morphogenesis of embryonic epithelium", "Motor behavior", "Motor learning", "Motor neuron apoptotic process", "Motor neuron axon guidance", "Mrna 3 end processing", "Mrna 3 end processing by stem loop binding and cleavage", "Mrna 3 splice site recognition", "Mrna 5 splice site recognition", "Mrna alternative polyadenylation", "Mrna catabolic process", "Mrna cis splicing via spliceosome", "Mrna cleavage", "Mrna cleavage involved in mrna processing", "Mrna destabilization mediated gene silencing", "Mrna export from nucleus", "Mrna metabolic process", "Mrna methylation", "Mrna modification", "Mrna processing", "Mrna pseudouridine synthesis", "Mrna splice site selection", "Mrna transcription", "Mrna transport", "Mucopolysaccharide metabolic process", "Mucosa associated lymphoid tissue development", "Mucus secretion", "Multi multicellular organism process", "Multi organism reproductive process", "Multicellular organism aging", "Multicellular organism growth", "Multicellular organism reproduction", "Multicellular organismal homeostasis", "Multicellular organismal movement", "Multicellular organismal response to stress", "Multicellular organismal signaling", "Multivesicular body organization", "Multivesicular body sorting pathway", "Muscle adaptation", "Muscle cell apoptotic process", "Muscle cell cellular homeostasis", "Muscle cell development", "Muscle cell differentiation", "Muscle cell migration", "Muscle cell proliferation", "Muscle contraction", "Muscle hypertrophy", "Muscle hypertrophy in response to stress", "Muscle organ development", "Muscle organ morphogenesis", "Muscle structure development", "Muscle system process", "Muscle tissue development", "Myd88 dependent toll like receptor signaling pathway", "Myelin assembly", "Myelin maintenance", "Myeloid cell activation involved in immune response", "Myeloid cell apoptotic process", "Myeloid cell development", "Myeloid cell differentiation", "Myeloid cell homeostasis", "Myeloid dendritic cell activation", "Myeloid dendritic cell cytokine production", "Myeloid leukocyte activation", "Myeloid leukocyte cytokine production", "Myeloid leukocyte differentiation", "Myeloid leukocyte mediated immunity", "Myeloid leukocyte migration", "Myeloid progenitor cell differentiation", "Myoblast differentiation", "Myoblast fusion", "Myoblast migration", "Myofibroblast differentiation", "Myosin filament organization", "Myotube cell development", "Myotube differentiation", "N acetylglucosamine metabolic process", "N acetylneuraminate catabolic process", "N acetylneuraminate metabolic process", "N acylethanolamine metabolic process", "N glycan processing", "N terminal peptidyl methionine acetylation", "N terminal protein amino acid acetylation", "N terminal protein amino acid modification", "N terminal protein lipidation", "Nad biosynthesis via nicotinamide riboside salvage pathway", "Nad metabolic process", "Nadh dehydrogenase complex assembly", "Nadh metabolic process", "Nadh oxidation", "Nadh regeneration", "Nadp metabolic process", "Nadph regeneration", "Natural killer cell activation", "Natural killer cell activation involved in immune response", "Natural killer cell degranulation", "Natural killer cell differentiation", "Natural killer cell mediated immunity", "Ncrna 3 end processing", "Ncrna catabolic process", "Ncrna export from nucleus", "Ncrna metabolic process", "Ncrna processing", "Ncrna transcription", "Necroptotic signaling pathway", "Necrotic cell death", "Negative chemotaxis", "Negative regulation by host of viral genome replication", "Negative regulation by host of viral process", "Negative regulation by host of viral transcription", "Negative regulation of actin filament bundle assembly", "Negative regulation of actin filament depolymerization", "Negative regulation of actin filament polymerization", "Negative regulation of actin nucleation", "Negative regulation of activated t cell proliferation", "Negative regulation of activin receptor signaling pathway", "Negative regulation of adaptive immune response", "Negative regulation of adenylate cyclase activating adrenergic receptor signaling pathway", "Negative regulation of adenylate cyclase activating g protein coupled receptor signaling pathway", "Negative regulation of adenylate cyclase activity", "Negative regulation of alcohol biosynthetic process", "Negative regulation of alpha beta t cell activation", "Negative regulation of alpha beta t cell differentiation", "Negative regulation of alpha beta t cell proliferation", "Negative regulation of amine transport", "Negative regulation of amino acid transport", "Negative regulation of amyloid beta clearance", "Negative regulation of amyloid fibril formation", "Negative regulation of amyloid precursor protein biosynthetic process", "Negative regulation of amyloid precursor protein catabolic process", "Negative regulation of androgen receptor signaling pathway", "Negative regulation of anion transmembrane transport", "Negative regulation of anion transport", "Negative regulation of anoikis", "Negative regulation of antigen receptor mediated signaling pathway", "Negative regulation of apoptotic process involved in development", "Negative regulation of apoptotic signaling pathway", "Negative regulation of arp2 3 complex mediated actin nucleation", "Negative regulation of astrocyte activation", "Negative regulation of astrocyte differentiation", "Negative regulation of atp biosynthetic process", "Negative regulation of atp dependent activity", "Negative regulation of atp metabolic process", "Negative regulation of autophagosome assembly", "Negative regulation of autophagosome maturation", "Negative regulation of autophagy", "Negative regulation of autophagy of mitochondrion", "Negative regulation of axon extension", "Negative regulation of axonogenesis", "Negative regulation of b cell activation", "Negative regulation of b cell apoptotic process", "Negative regulation of b cell differentiation", "Negative regulation of b cell mediated immunity", "Negative regulation of b cell proliferation", "Negative regulation of bicellular tight junction assembly", "Negative regulation of binding", "Negative regulation of biomineralization", "Negative regulation of biosynthetic process", "Negative regulation of blood circulation", "Negative regulation of blood pressure", "Negative regulation of blood vessel endothelial cell migration", "Negative regulation of bmp signaling pathway", "Negative regulation of bone remodeling", "Negative regulation of calcineurin mediated signaling", "Negative regulation of calcium ion dependent exocytosis", "Negative regulation of calcium ion import", "Negative regulation of calcium ion transmembrane transport", "Negative regulation of calcium ion transport", "Negative regulation of calcium ion transport into cytosol", "Negative regulation of calcium mediated signaling", "Negative regulation of camp dependent protein kinase activity", "Negative regulation of canonical wnt signaling pathway", "Negative regulation of carbohydrate metabolic process", "Negative regulation of cardiac muscle adaptation", "Negative regulation of cardiac muscle contraction", "Negative regulation of cardiac muscle tissue growth", "Negative regulation of cartilage development", "Negative regulation of catabolic process", "Negative regulation of catalytic activity", "Negative regulation of cation channel activity", "Negative regulation of cd4 positive alpha beta t cell activation", "Negative regulation of cd4 positive alpha beta t cell differentiation", "Negative regulation of cell activation", "Negative regulation of cell adhesion", "Negative regulation of cell adhesion mediated by integrin", "Negative regulation of cell aging", "Negative regulation of cell cell adhesion", "Negative regulation of cell cycle", "Negative regulation of cell cycle checkpoint", "Negative regulation of cell cycle g1 s phase transition", "Negative regulation of cell cycle g2 m phase transition", "Negative regulation of cell cycle phase transition", "Negative regulation of cell cycle process", "Negative regulation of cell death", "Negative regulation of cell development", "Negative regulation of cell differentiation", "Negative regulation of cell growth", "Negative regulation of cell growth involved in cardiac muscle cell development", "Negative regulation of cell junction assembly", "Negative regulation of cell killing", "Negative regulation of cell matrix adhesion", "Negative regulation of cell migration involved in sprouting angiogenesis", "Negative regulation of cell morphogenesis involved in differentiation", "Negative regulation of cell population proliferation", "Negative regulation of cell projection organization", "Negative regulation of cell size", "Negative regulation of cell substrate adhesion", "Negative regulation of cell substrate junction organization", "Negative regulation of cell volume", "Negative regulation of cellular amide metabolic process", "Negative regulation of cellular catabolic process", "Negative regulation of cellular component organization", "Negative regulation of cellular macromolecule biosynthetic process", "Negative regulation of cellular protein catabolic process", "Negative regulation of cellular respiration", "Negative regulation of cellular response to growth factor stimulus", "Negative regulation of cellular response to hypoxia", "Negative regulation of cellular response to insulin stimulus", "Negative regulation of cellular senescence", "Negative regulation of centriole replication", "Negative regulation of centrosome duplication", "Negative regulation of chemokine mediated signaling pathway", "Negative regulation of chemotaxis", "Negative regulation of cholesterol metabolic process", "Negative regulation of chondrocyte differentiation", "Negative regulation of chromatin binding", "Negative regulation of chromatin organization", "Negative regulation of chromosome organization", "Negative regulation of cilium assembly", "Negative regulation of circadian rhythm", "Negative regulation of cold induced thermogenesis", "Negative regulation of collateral sprouting", "Negative regulation of cyclic nucleotide phosphodiesterase activity", "Negative regulation of cyclin dependent protein serine threonine kinase activity", "Negative regulation of cysteine type endopeptidase activity", "Negative regulation of cysteine type endopeptidase activity involved in apoptotic signaling pathway", "Negative regulation of cytokine production", "Negative regulation of cytokine production involved in immune response", "Negative regulation of cytokine production involved in inflammatory response", "Negative regulation of cytoplasmic translation", "Negative regulation of cytoskeleton organization", "Negative regulation of cytosolic calcium ion concentration", "Negative regulation of defense response", "Negative regulation of defense response to virus", "Negative regulation of delayed rectifier potassium channel activity", "Negative regulation of dendrite development", "Negative regulation of dendrite morphogenesis", "Negative regulation of dendritic spine development", "Negative regulation of dendritic spine morphogenesis", "Negative regulation of dephosphorylation", "Negative regulation of developmental growth", "Negative regulation of developmental process", "Negative regulation of digestive system process", "Negative regulation of dna binding", "Negative regulation of dna binding transcription factor activity", "Negative regulation of dna biosynthetic process", "Negative regulation of dna damage checkpoint", "Negative regulation of dna damage response signal transduction by p53 class mediator", "Negative regulation of dna dependent dna replication", "Negative regulation of dna metabolic process", "Negative regulation of dna recombination", "Negative regulation of dna repair", "Negative regulation of dna replication", "Negative regulation of dna templated transcription elongation", "Negative regulation of dna templated transcription initiation", "Negative regulation of double strand break repair via homologous recombination", "Negative regulation of endocytosis", "Negative regulation of endoplasmic reticulum calcium ion concentration", "Negative regulation of endoplasmic reticulum stress induced eif2 alpha phosphorylation", "Negative regulation of endoplasmic reticulum stress induced intrinsic apoptotic signaling pathway", "Negative regulation of endoplasmic reticulum unfolded protein response", "Negative regulation of endothelial cell proliferation", "Negative regulation of epidermal growth factor activated receptor activity", "Negative regulation of epidermis development", "Negative regulation of epithelial cell apoptotic process", "Negative regulation of epithelial cell differentiation", "Negative regulation of epithelial cell migration", "Negative regulation of epithelial cell proliferation", "Negative regulation of erad pathway", "Negative regulation of erbb signaling pathway", "Negative regulation of erk1 and erk2 cascade", "Negative regulation of erythrocyte differentiation", "Negative regulation of establishment of protein localization", "Negative regulation of establishment of protein localization to mitochondrion", "Negative regulation of excitatory postsynaptic potential", "Negative regulation of execution phase of apoptosis", "Negative regulation of exocytosis", "Negative regulation of extrinsic apoptotic signaling pathway", "Negative regulation of extrinsic apoptotic signaling pathway via death domain receptors", "Negative regulation of fat cell differentiation", "Negative regulation of fatty acid beta oxidation", "Negative regulation of fatty acid biosynthetic process", "Negative regulation of fatty acid metabolic process", "Negative regulation of fatty acid oxidation", "Negative regulation of fatty acid transport", "Negative regulation of fibroblast apoptotic process", "Negative regulation of fibroblast migration", "Negative regulation of fibroblast proliferation", "Negative regulation of filopodium assembly", "Negative regulation of g protein coupled receptor signaling pathway", "Negative regulation of gene expression", "Negative regulation of gene expression epigenetic", "Negative regulation of glial cell differentiation", "Negative regulation of glial cell proliferation", "Negative regulation of gliogenesis", "Negative regulation of glucocorticoid metabolic process", "Negative regulation of gluconeogenesis", "Negative regulation of glucose import", "Negative regulation of glucose transmembrane transport", "Negative regulation of glycogen metabolic process", "Negative regulation of glycolytic process", "Negative regulation of glycoprotein metabolic process", "Negative regulation of golgi to plasma membrane protein transport", "Negative regulation of granulocyte chemotaxis", "Negative regulation of granulocyte differentiation", "Negative regulation of growth", "Negative regulation of gtpase activity", "Negative regulation of guanyl nucleotide exchange factor activity", "Negative regulation of heart rate", "Negative regulation of helicase activity", "Negative regulation of hematopoietic progenitor cell differentiation", "Negative regulation of hemopoiesis", "Negative regulation of high voltage gated calcium channel activity", "Negative regulation of hippo signaling", "Negative regulation of histone acetylation", "Negative regulation of histone h3 k27 methylation", "Negative regulation of histone h3 k4 methylation", "Negative regulation of histone h3 k9 methylation", "Negative regulation of histone h3 k9 trimethylation", "Negative regulation of histone h4 acetylation", "Negative regulation of histone methylation", "Negative regulation of histone modification", "Negative regulation of histone phosphorylation", "Negative regulation of homotypic cell cell adhesion", "Negative regulation of hormone biosynthetic process", "Negative regulation of hormone metabolic process", "Negative regulation of hormone secretion", "Negative regulation of hydrogen peroxide mediated programmed cell death", "Negative regulation of hydrolase activity", "Negative regulation of hypoxia induced intrinsic apoptotic signaling pathway", "Negative regulation of i kappab kinase nf kappab signaling", "Negative regulation of immune effector process", "Negative regulation of immune response", "Negative regulation of immune system process", "Negative regulation of immunoglobulin production", "Negative regulation of inclusion body assembly", "Negative regulation of inflammatory response", "Negative regulation of inflammatory response to antigenic stimulus", "Negative regulation of innate immune response", "Negative regulation of interferon gamma production", "Negative regulation of interleukin 12 production", "Negative regulation of interleukin 2 production", "Negative regulation of interleukin 6 production", "Negative regulation of interleukin 8 production", "Negative regulation of intracellular estrogen receptor signaling pathway", "Negative regulation of intracellular protein transport", "Negative regulation of intracellular signal transduction", "Negative regulation of intracellular steroid hormone receptor signaling pathway", "Negative regulation of intracellular transport", "Negative regulation of intrinsic apoptotic signaling pathway", "Negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator", "Negative regulation of intrinsic apoptotic signaling pathway in response to dna damage", "Negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress", "Negative regulation of ion transmembrane transport", "Negative regulation of ion transmembrane transporter activity", "Negative regulation of ion transport", "Negative regulation of ire1 mediated unfolded protein response", "Negative regulation of isotype switching", "Negative regulation of jnk cascade", "Negative regulation of jun kinase activity", "Negative regulation of keratinocyte differentiation", "Negative regulation of keratinocyte proliferation", "Negative regulation of kidney development", "Negative regulation of kinase activity", "Negative regulation of lamellipodium assembly", "Negative regulation of lamellipodium organization", "Negative regulation of leukocyte apoptotic process", "Negative regulation of leukocyte cell cell adhesion", "Negative regulation of leukocyte chemotaxis", "Negative regulation of leukocyte degranulation", "Negative regulation of leukocyte mediated immunity", "Negative regulation of leukocyte migration", "Negative regulation of leukocyte proliferation", "Negative regulation of lipase activity", "Negative regulation of lipid biosynthetic process", "Negative regulation of lipid catabolic process", "Negative regulation of lipid kinase activity", "Negative regulation of lipid localization", "Negative regulation of lipid metabolic process", "Negative regulation of lipid storage", "Negative regulation of lipid transport", "Negative regulation of lipopolysaccharide mediated signaling pathway", "Negative regulation of lipoprotein lipase activity", "Negative regulation of lipoprotein particle clearance", "Negative regulation of locomotion", "Negative regulation of long term synaptic potentiation", "Negative regulation of low density lipoprotein particle clearance", "Negative regulation of low density lipoprotein receptor activity", "Negative regulation of lyase activity", "Negative regulation of lymphocyte activation", "Negative regulation of lymphocyte apoptotic process", "Negative regulation of lymphocyte differentiation", "Negative regulation of lymphocyte mediated immunity", "Negative regulation of lymphocyte migration", "Negative regulation of macroautophagy", "Negative regulation of macrophage activation", "Negative regulation of macrophage chemotaxis", "Negative regulation of macrophage migration", "Negative regulation of map kinase activity", "Negative regulation of mapk cascade", "Negative regulation of mast cell activation", "Negative regulation of mast cell activation involved in immune response", "Negative regulation of mast cell degranulation", "Negative regulation of megakaryocyte differentiation", "Negative regulation of meiotic cell cycle", "Negative regulation of meiotic nuclear division", "Negative regulation of membrane permeability", "Negative regulation of membrane potential", "Negative regulation of mesenchymal cell proliferation", "Negative regulation of metalloendopeptidase activity", "Negative regulation of metallopeptidase activity", "Negative regulation of metaphase anaphase transition of cell cycle", "Negative regulation of mhc class ii biosynthetic process", "Negative regulation of microglial cell activation", "Negative regulation of microtubule polymerization", "Negative regulation of microtubule polymerization or depolymerization", "Negative regulation of mitochondrial fusion", "Negative regulation of mitochondrial membrane permeability", "Negative regulation of mitochondrial membrane permeability involved in apoptotic process", "Negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway", "Negative regulation of mitochondrion organization", "Negative regulation of mitophagy", "Negative regulation of mitotic cell cycle", "Negative regulation of mitotic cell cycle phase transition", "Negative regulation of molecular function", "Negative regulation of monocyte chemotaxis", "Negative regulation of monocyte differentiation", "Negative regulation of mononuclear cell migration", "Negative regulation of monooxygenase activity", "Negative regulation of mrna 3 end processing", "Negative regulation of mrna catabolic process", "Negative regulation of mrna metabolic process", "Negative regulation of mrna processing", "Negative regulation of mrna splicing via spliceosome", "Negative regulation of multicellular organism growth", "Negative regulation of multicellular organismal process", "Negative regulation of muscle adaptation", "Negative regulation of muscle cell apoptotic process", "Negative regulation of muscle cell differentiation", "Negative regulation of muscle contraction", "Negative regulation of muscle hypertrophy", "Negative regulation of muscle organ development", "Negative regulation of muscle tissue development", "Negative regulation of myelination", "Negative regulation of myeloid cell apoptotic process", "Negative regulation of myeloid cell differentiation", "Negative regulation of myeloid leukocyte differentiation", "Negative regulation of myeloid leukocyte mediated immunity", "Negative regulation of myoblast differentiation", "Negative regulation of myosin light chain phosphatase activity", "Negative regulation of natural killer cell mediated immunity", "Negative regulation of necrotic cell death", "Negative regulation of nervous system development", "Negative regulation of nervous system process", "Negative regulation of neural precursor cell proliferation", "Negative regulation of neuroblast proliferation", "Negative regulation of neuroinflammatory response", "Negative regulation of neuron apoptotic process", "Negative regulation of neuron death", "Negative regulation of neuron differentiation", "Negative regulation of neuron migration", "Negative regulation of neuron projection development", "Negative regulation of neuron projection regeneration", "Negative regulation of neurotransmitter secretion", "Negative regulation of neurotransmitter transport", "Negative regulation of neutrophil migration", "Negative regulation of nf kappab transcription factor activity", "Negative regulation of nik nf kappab signaling", "Negative regulation of nitric oxide metabolic process", "Negative regulation of nitric oxide synthase activity", "Negative regulation of notch signaling pathway", "Negative regulation of nuclear division", "Negative regulation of nuclear transcribed mrna catabolic process deadenylation dependent decay", "Negative regulation of nuclear transcribed mrna catabolic process nonsense mediated decay", "Negative regulation of nuclease activity", "Negative regulation of nucleobase containing compound metabolic process", "Negative regulation of nucleocytoplasmic transport", "Negative regulation of nucleotide biosynthetic process", "Negative regulation of nucleotide metabolic process", "Negative regulation of oligodendrocyte differentiation", "Negative regulation of organ growth", "Negative regulation of organelle assembly", "Negative regulation of organelle organization", "Negative regulation of organic acid transport", "Negative regulation of osteoblast differentiation", "Negative regulation of osteoblast proliferation", "Negative regulation of osteoclast differentiation", "Negative regulation of oxidative phosphorylation", "Negative regulation of oxidative stress induced cell death", "Negative regulation of oxidative stress induced intrinsic apoptotic signaling pathway", "Negative regulation of oxidative stress induced neuron death", "Negative regulation of oxidative stress induced neuron intrinsic apoptotic signaling pathway", "Negative regulation of oxidoreductase activity", "Negative regulation of p38mapk cascade", "Negative regulation of peptidase activity", "Negative regulation of peptide secretion", "Negative regulation of peptidyl lysine acetylation", "Negative regulation of peptidyl serine phosphorylation", "Negative regulation of peptidyl threonine phosphorylation", "Negative regulation of peptidyl tyrosine phosphorylation", "Negative regulation of perk mediated unfolded protein response", "Negative regulation of phagocytosis", "Negative regulation of phosphatase activity", "Negative regulation of phosphatidylinositol 3 kinase signaling", "Negative regulation of phospholipase activity", "Negative regulation of phospholipid metabolic process", "Negative regulation of phosphoprotein phosphatase activity", "Negative regulation of phosphorus metabolic process", "Negative regulation of phosphorylation", "Negative regulation of plasma membrane bounded cell projection assembly", "Negative regulation of platelet derived growth factor receptor signaling pathway", "Negative regulation of posttranscriptional gene silencing", "Negative regulation of potassium ion transmembrane transport", "Negative regulation of potassium ion transport", "Negative regulation of production of mirnas involved in gene silencing by mirna", "Negative regulation of production of molecular mediator of immune response", "Negative regulation of programmed necrotic cell death", "Negative regulation of prostaglandin biosynthetic process", "Negative regulation of proteasomal protein catabolic process", "Negative regulation of proteasomal ubiquitin dependent protein catabolic process", "Negative regulation of protein acetylation", "Negative regulation of protein autophosphorylation", "Negative regulation of protein binding", "Negative regulation of protein catabolic process", "Negative regulation of protein containing complex assembly", "Negative regulation of protein containing complex disassembly", "Negative regulation of protein dephosphorylation", "Negative regulation of protein exit from endoplasmic reticulum", "Negative regulation of protein export from nucleus", "Negative regulation of protein import into nucleus", "Negative regulation of protein k63 linked ubiquitination", "Negative regulation of protein kinase activity by regulation of protein phosphorylation", "Negative regulation of protein kinase b signaling", "Negative regulation of protein localization", "Negative regulation of protein localization to cell periphery", "Negative regulation of protein localization to cell surface", "Negative regulation of protein localization to membrane", "Negative regulation of protein localization to nucleus", "Negative regulation of protein maturation", "Negative regulation of protein metabolic process", "Negative regulation of protein modification by small protein conjugation or removal", "Negative regulation of protein modification process", "Negative regulation of protein polymerization", "Negative regulation of protein polyubiquitination", "Negative regulation of protein secretion", "Negative regulation of protein serine threonine kinase activity", "Negative regulation of protein sumoylation", "Negative regulation of protein targeting to membrane", "Negative regulation of protein targeting to mitochondrion", "Negative regulation of protein tyrosine kinase activity", "Negative regulation of proteolysis", "Negative regulation of proteolysis involved in cellular protein catabolic process", "Negative regulation of reactive oxygen species biosynthetic process", "Negative regulation of reactive oxygen species metabolic process", "Negative regulation of receptor binding", "Negative regulation of receptor internalization", "Negative regulation of receptor mediated endocytosis", "Negative regulation of receptor recycling", "Negative regulation of receptor signaling pathway via jak stat", "Negative regulation of receptor signaling pathway via stat", "Negative regulation of regulated secretory pathway", "Negative regulation of release of cytochrome c from mitochondria", "Negative regulation of reproductive process", "Negative regulation of respiratory burst", "Negative regulation of respiratory burst involved in inflammatory response", "Negative regulation of response to biotic stimulus", "Negative regulation of response to cytokine stimulus", "Negative regulation of response to dna damage stimulus", "Negative regulation of response to endoplasmic reticulum stress", "Negative regulation of response to external stimulus", "Negative regulation of response to food", "Negative regulation of response to oxidative stress", "Negative regulation of response to reactive oxygen species", "Negative regulation of response to stimulus", "Negative regulation of response to wounding", "Negative regulation of retinoic acid receptor signaling pathway", "Negative regulation of rho protein signal transduction", "Negative regulation of rig i signaling pathway", "Negative regulation of rna catabolic process", "Negative regulation of rna splicing", "Negative regulation of ruffle assembly", "Negative regulation of ryanodine sensitive calcium release channel activity", "Negative regulation of schwann cell proliferation", "Negative regulation of secondary metabolite biosynthetic process", "Negative regulation of secretion", "Negative regulation of sequestering of triglyceride", "Negative regulation of signal transduction by p53 class mediator", "Negative regulation of signal transduction in absence of ligand", "Negative regulation of signaling", "Negative regulation of signaling receptor activity", "Negative regulation of single stranded viral rna replication via double stranded dna intermediate", "Negative regulation of sister chromatid cohesion", "Negative regulation of small gtpase mediated signal transduction", "Negative regulation of small molecule metabolic process", "Negative regulation of smooth muscle cell apoptotic process", "Negative regulation of smooth muscle cell differentiation", "Negative regulation of smooth muscle cell migration", "Negative regulation of smooth muscle cell proliferation", "Negative regulation of smoothened signaling pathway", "Negative regulation of smoothened signaling pathway involved in dorsal ventral neural tube patterning", "Negative regulation of sodium ion transmembrane transport", "Negative regulation of sodium ion transport", "Negative regulation of sprouting angiogenesis", "Negative regulation of stem cell differentiation", "Negative regulation of steroid metabolic process", "Negative regulation of sterol transport", "Negative regulation of stress activated protein kinase signaling cascade", "Negative regulation of striated muscle cell apoptotic process", "Negative regulation of striated muscle cell differentiation", "Negative regulation of striated muscle contraction", "Negative regulation of supramolecular fiber organization", "Negative regulation of synapse organization", "Negative regulation of synaptic transmission", "Negative regulation of synaptic transmission glutamatergic", "Negative regulation of synaptic vesicle exocytosis", "Negative regulation of systemic arterial blood pressure", "Negative regulation of t cell apoptotic process", "Negative regulation of t cell differentiation", "Negative regulation of t cell proliferation", "Negative regulation of t cell receptor signaling pathway", "Negative regulation of t helper cell differentiation", "Negative regulation of telomerase activity", "Negative regulation of telomere capping", "Negative regulation of telomere maintenance", "Negative regulation of telomere maintenance via telomerase", "Negative regulation of telomere maintenance via telomere lengthening", "Negative regulation of thymocyte apoptotic process", "Negative regulation of tissue remodeling", "Negative regulation of toll like receptor signaling pathway", "Negative regulation of tor signaling", "Negative regulation of transcription by competitive promoter binding", "Negative regulation of transcription by rna polymerase i", "Negative regulation of transcription by rna polymerase ii", "Negative regulation of transcription from rna polymerase ii promoter in response to stress", "Negative regulation of transcription initiation from rna polymerase ii promoter", "Negative regulation of transcription regulatory region dna binding", "Negative regulation of transferase activity", "Negative regulation of transforming growth factor beta production", "Negative regulation of transforming growth factor beta receptor signaling pathway", "Negative regulation of transforming growth factor beta1 production", "Negative regulation of translational elongation", "Negative regulation of translational initiation", "Negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway", "Negative regulation of transmembrane transport", "Negative regulation of transport", "Negative regulation of transporter activity", "Negative regulation of trophoblast cell migration", "Negative regulation of tumor necrosis factor superfamily cytokine production", "Negative regulation of type 2 immune response", "Negative regulation of type b pancreatic cell apoptotic process", "Negative regulation of type i interferon mediated signaling pathway", "Negative regulation of type i interferon production", "Negative regulation of tyrosine phosphorylation of stat protein", "Negative regulation of ubiquitin dependent protein catabolic process", "Negative regulation of ubiquitin protein ligase activity", "Negative regulation of ubiquitin protein transferase activity", "Negative regulation of vascular associated smooth muscle cell apoptotic process", "Negative regulation of vascular associated smooth muscle cell differentiation", "Negative regulation of vascular associated smooth muscle cell migration", "Negative regulation of vascular associated smooth muscle cell proliferation", "Negative regulation of vascular endothelial growth factor production", "Negative regulation of vascular endothelial growth factor receptor signaling pathway", "Negative regulation of vascular permeability", "Negative regulation of vasculature development", "Negative regulation of viral entry into host cell", "Negative regulation of viral genome replication", "Negative regulation of viral induced cytoplasmic pattern recognition receptor signaling pathway", "Negative regulation of viral life cycle", "Negative regulation of viral process", "Negative regulation of viral transcription", "Negative regulation of vitamin d biosynthetic process", "Negative regulation of vitamin metabolic process", "Negative regulation of voltage gated calcium channel activity", "Negative regulation of voltage gated potassium channel activity", "Negative regulation of wnt signaling pathway", "Negative regulation of wound healing", "Nephron development", "Nephron epithelium development", "Nephron morphogenesis", "Nephron tubule epithelial cell differentiation", "Nephron tubule formation", "Nerve development", "Nerve growth factor signaling pathway", "Nervous system process", "Nervous system process involved in regulation of systemic arterial blood pressure", "Netrin activated signaling pathway", "Neural crest cell differentiation", "Neural crest cell migration", "Neural crest formation", "Neural nucleus development", "Neural plate development", "Neural precursor cell proliferation", "Neural retina development", "Neural tube development", "Neural tube formation", "Neural tube patterning", "Neuroblast division", "Neuroblast proliferation", "Neuroendocrine cell differentiation", "Neuroepithelial cell differentiation", "Neurofilament cytoskeleton organization", "Neurogenesis", "Neuroinflammatory response", "Neuromuscular junction development", "Neuromuscular process", "Neuromuscular process controlling balance", "Neuromuscular process controlling posture", "Neuron apoptotic process", "Neuron cellular homeostasis", "Neuron death", "Neuron death in response to hydrogen peroxide", "Neuron death in response to oxidative stress", "Neuron development", "Neuron differentiation", "Neuron fate commitment", "Neuron fate determination", "Neuron intrinsic apoptotic signaling pathway in response to oxidative stress", "Neuron maturation", "Neuron migration", "Neuron projection arborization", "Neuron projection extension", "Neuron projection extension involved in neuron projection guidance", "Neuron projection guidance", "Neuron projection maintenance", "Neuron projection organization", "Neuron projection regeneration", "Neuron recognition", "Neuron remodeling", "Neuronal action potential", "Neuronal ion channel clustering", "Neuronal stem cell population maintenance", "Neuropeptide signaling pathway", "Neurotransmitter biosynthetic process", "Neurotransmitter catabolic process", "Neurotransmitter gated ion channel clustering", "Neurotransmitter metabolic process", "Neurotransmitter receptor internalization", "Neurotransmitter receptor localization to postsynaptic specialization membrane", "Neurotransmitter receptor transport", "Neurotransmitter receptor transport endosome to postsynaptic membrane", "Neurotransmitter receptor transport postsynaptic endosome to lysosome", "Neurotransmitter receptor transport to plasma membrane", "Neurotransmitter reuptake", "Neurotransmitter secretion", "Neurotransmitter transport", "Neurotransmitter uptake", "Neurotrophin production", "Neurotrophin signaling pathway", "Neurotrophin trk receptor signaling pathway", "Neutral amino acid transport", "Neutral lipid biosynthetic process", "Neutral lipid catabolic process", "Neutral lipid metabolic process", "Neutrophil activation involved in immune response", "Neutrophil apoptotic process", "Neutrophil chemotaxis", "Neutrophil clearance", "Neutrophil degranulation", "Neutrophil differentiation", "Neutrophil homeostasis", "Neutrophil mediated immunity", "Neutrophil migration", "Nik nf kappab signaling", "Nitric oxide mediated signal transduction", "Nitric oxide synthase biosynthetic process", "Nitrogen compound transport", "Nk t cell activation", "Nk t cell differentiation", "Nls bearing protein import into nucleus", "Non canonical wnt signaling pathway", "Non lytic viral release", "Non membrane bounded organelle assembly", "Non motile cilium assembly", "Nonribosomal peptide biosynthetic process", "Nose development", "Notch receptor processing", "Notch signaling pathway", "Nuclear body organization", "Nuclear chromosome segregation", "Nuclear envelope organization", "Nuclear export", "Nuclear membrane organization", "Nuclear membrane reassembly", "Nuclear migration", "Nuclear ncrna surveillance", "Nuclear pore complex assembly", "Nuclear pore organization", "Nuclear transcribed mrna catabolic process", "Nuclear transcribed mrna catabolic process deadenylation dependent decay", "Nuclear transcribed mrna catabolic process deadenylation independent decay", "Nuclear transcribed mrna catabolic process exonucleolytic", "Nuclear transcribed mrna catabolic process exonucleolytic 3 5", "Nuclear transcribed mrna catabolic process nonsense mediated decay", "Nuclear transcribed mrna poly a tail shortening", "Nuclear transport", "Nucleic acid phosphodiester bond hydrolysis", "Nucleobase biosynthetic process", "Nucleobase catabolic process", "Nucleobase containing compound transport", "Nucleobase containing small molecule biosynthetic process", "Nucleobase containing small molecule catabolic process", "Nucleobase containing small molecule interconversion", "Nucleobase containing small molecule metabolic process", "Nucleobase metabolic process", "Nucleobase transport", "Nucleolar chromatin organization", "Nucleolar large rrna transcription by rna polymerase i", "Nucleolus organization", "Nucleoside bisphosphate biosynthetic process", "Nucleoside bisphosphate catabolic process", "Nucleoside bisphosphate metabolic process", "Nucleoside catabolic process", "Nucleoside diphosphate biosynthetic process", "Nucleoside diphosphate catabolic process", "Nucleoside diphosphate metabolic process", "Nucleoside metabolic process", "Nucleoside monophosphate biosynthetic process", "Nucleoside monophosphate catabolic process", "Nucleoside monophosphate metabolic process", "Nucleoside monophosphate phosphorylation", "Nucleoside phosphate biosynthetic process", "Nucleoside phosphate catabolic process", "Nucleoside salvage", "Nucleoside transmembrane transport", "Nucleoside transport", "Nucleoside triphosphate biosynthetic process", "Nucleoside triphosphate catabolic process", "Nucleoside triphosphate metabolic process", "Nucleosome assembly", "Nucleosome mobilization", "Nucleosome organization", "Nucleosome positioning", "Nucleotide binding domain leucine rich repeat containing receptor signaling pathway", "Nucleotide binding oligomerization domain containing 2 signaling pathway", "Nucleotide excision repair", "Nucleotide excision repair dna gap filling", "Nucleotide excision repair dna incision", "Nucleotide phosphorylation", "Nucleotide salvage", "Nucleotide sugar biosynthetic process", "Nucleotide sugar metabolic process", "Nucleotide sugar transmembrane transport", "Nucleotide transmembrane transport", "Nucleotide transport", "Nucleus localization", "Nucleus organization", "O glycan processing", "Observational learning", "Odontoblast differentiation", "Odontogenesis", "Odontogenesis of dentin containing tooth", "Olefinic compound biosynthetic process", "Olefinic compound metabolic process", "Olfactory behavior", "Olfactory bulb interneuron development", "Olfactory bulb interneuron differentiation", "Olfactory lobe development", "Oligodendrocyte development", "Oligodendrocyte differentiation", "Oligopeptide transport", "Oligosaccharide biosynthetic process", "Oligosaccharide catabolic process", "Oligosaccharide lipid intermediate biosynthetic process", "Oligosaccharide metabolic process", "One carbon metabolic process", "Oocyte construction", "Oocyte differentiation", "Oocyte maturation", "Oogenesis", "Optic nerve development", "Organ growth", "Organ induction", "Organ or tissue specific immune response", "Organelle assembly", "Organelle disassembly", "Organelle fission", "Organelle fusion", "Organelle inheritance", "Organelle localization", "Organelle membrane fusion", "Organelle transport along microtubule", "Organic acid biosynthetic process", "Organic acid catabolic process", "Organic acid metabolic process", "Organic acid transmembrane transport", "Organic acid transport", "Organic anion transport", "Organic cation transport", "Organic cyclic compound catabolic process", "Organic hydroxy compound biosynthetic process", "Organic hydroxy compound catabolic process", "Organic hydroxy compound metabolic process", "Organic hydroxy compound transport", "Organism emergence from protective structure", "Organonitrogen compound biosynthetic process", "Organonitrogen compound catabolic process", "Organophosphate biosynthetic process", "Organophosphate catabolic process", "Organophosphate ester transport", "Organophosphate metabolic process", "Ornithine metabolic process", "Ornithine transport", "Ossification", "Osteoblast differentiation", "Osteoblast proliferation", "Osteoclast development", "Osteoclast differentiation", "Outer dynein arm assembly", "Outer ear morphogenesis", "Outer mitochondrial membrane organization", "Outflow tract morphogenesis", "Ovarian follicle development", "Oviduct development", "Ovulation", "Ovulation cycle", "Ovulation cycle process", "Ovulation from ovarian follicle", "Oxaloacetate metabolic process", "Oxaloacetate transport", "Oxidative demethylation", "Oxidative dna demethylation", "Oxidative phosphorylation", "Oxidative rna demethylation", "Oxygen homeostasis", "P body assembly", "P38mapk cascade", "Pallium development", "Pancreas development", "Pancreatic juice secretion", "Pantothenate metabolic process", "Parallel actin filament bundle assembly", "Paranodal junction assembly", "Parathyroid gland development", "Paraxial mesoderm development", "Paraxial mesoderm formation", "Paraxial mesoderm morphogenesis", "Parkin mediated stimulation of mitophagy in response to mitochondrial depolarization", "Pathway restricted smad protein phosphorylation", "Pattern recognition receptor signaling pathway", "Pattern specification process", "Penetration of zona pellucida", "Penile erection", "Pentose catabolic process", "Pentose metabolic process", "Pentose phosphate shunt", "Pentose phosphate shunt non oxidative branch", "Peptide antigen assembly with mhc protein complex", "Peptide biosynthetic process", "Peptide catabolic process", "Peptide cross linking", "Peptide metabolic process", "Peptide transport", "Peptidyl amino acid modification", "Peptidyl arginine methylation", "Peptidyl arginine methylation to asymmetrical dimethyl arginine", "Peptidyl arginine modification", "Peptidyl arginine n methylation", "Peptidyl asparagine modification", "Peptidyl cysteine modification", "Peptidyl diphthamide biosynthetic process from peptidyl histidine", "Peptidyl glutamic acid modification", "Peptidyl glutamine methylation", "Peptidyl histidine modification", "Peptidyl lysine acetylation", "Peptidyl lysine deacetylation", "Peptidyl lysine dimethylation", "Peptidyl lysine hydroxylation", "Peptidyl lysine methylation", "Peptidyl lysine modification", "Peptidyl lysine monomethylation", "Peptidyl lysine trimethylation", "Peptidyl methionine modification", "Peptidyl proline hydroxylation", "Peptidyl proline hydroxylation to 4 hydroxy l proline", "Peptidyl proline modification", "Peptidyl serine autophosphorylation", "Peptidyl serine dephosphorylation", "Peptidyl serine modification", "Peptidyl threonine dephosphorylation", "Peptidyl threonine modification", "Peptidyl tyrosine dephosphorylation", "Peptidyl tyrosine dephosphorylation involved in inactivation of protein kinase activity", "Peptidyl tyrosine modification", "Pericardium development", "Peripheral nervous system axon regeneration", "Peripheral nervous system development", "Peripheral nervous system myelin maintenance", "Perk mediated unfolded protein response", "Peroxisomal transport", "Peroxisome fission", "Peroxisome organization", "Peroxisome proliferator activated receptor signaling pathway", "Ph reduction", "Phagocytosis", "Phagocytosis recognition", "Phagolysosome assembly", "Phagosome acidification", "Phagosome lysosome fusion", "Phagosome maturation", "Pharyngeal system development", "Phenol containing compound biosynthetic process", "Phenol containing compound catabolic process", "Phenol containing compound metabolic process", "Phenotypic switching", "Phosphagen metabolic process", "Phosphate ion transmembrane transport", "Phosphate ion transport", "Phosphatidic acid metabolic process", "Phosphatidylcholine acyl chain remodeling", "Phosphatidylcholine biosynthetic process", "Phosphatidylcholine catabolic process", "Phosphatidylcholine metabolic process", "Phosphatidylethanolamine biosynthetic process", "Phosphatidylethanolamine metabolic process", "Phosphatidylglycerol acyl chain remodeling", "Phosphatidylglycerol biosynthetic process", "Phosphatidylglycerol metabolic process", "Phosphatidylinositol 3 kinase signaling", "Phosphatidylinositol 3 phosphate biosynthetic process", "Phosphatidylinositol acyl chain remodeling", "Phosphatidylinositol biosynthetic process", "Phosphatidylinositol dephosphorylation", "Phosphatidylinositol metabolic process", "Phosphatidylinositol phosphate biosynthetic process", "Phosphatidylserine acyl chain remodeling", "Phosphatidylserine metabolic process", "Phospholipase c activating dopamine receptor signaling pathway", "Phospholipase c activating g protein coupled receptor signaling pathway", "Phospholipid biosynthetic process", "Phospholipid catabolic process", "Phospholipid dephosphorylation", "Phospholipid homeostasis", "Phospholipid metabolic process", "Phospholipid transport", "Phosphorylation", "Phosphorylation of rna polymerase ii c terminal domain", "Photoperiodism", "Photoreceptor cell development", "Photoreceptor cell differentiation", "Photoreceptor cell maintenance", "Photoreceptor cell outer segment organization", "Phototransduction", "Phototransduction visible light", "Physiological cardiac muscle hypertrophy", "Piecemeal microautophagy of the nucleus", "Pigment accumulation", "Pigment biosynthetic process", "Pigment cell differentiation", "Pigment granule localization", "Pigment granule maturation", "Pigment granule organization", "Pigment metabolic process", "Pigmentation", "Pinocytosis", "Pirna metabolic process", "Placenta blood vessel development", "Placenta development", "Planar cell polarity pathway involved in neural tube closure", "Plasma lipoprotein particle clearance", "Plasma membrane fusion", "Plasma membrane organization", "Plasma membrane phospholipid scrambling", "Plasma membrane raft assembly", "Plasma membrane raft organization", "Plasma membrane repair", "Plasma membrane to endosome transport", "Plasma membrane tubulation", "Plasminogen activation", "Platelet activating factor metabolic process", "Platelet activation", "Platelet aggregation", "Platelet derived growth factor receptor beta signaling pathway", "Platelet derived growth factor receptor signaling pathway", "Platelet morphogenesis", "Plus end directed organelle transport along microtubule", "Pml body organization", "Podosome assembly", "Pointed end actin filament capping", "Polarized epithelial cell differentiation", "Poly a plus mrna export from nucleus", "Poly n acetyllactosamine metabolic process", "Polyadenylation dependent rna catabolic process", "Polyadenylation dependent snorna 3 end processing", "Polyamine biosynthetic process", "Polyamine metabolic process", "Polyketide metabolic process", "Polyol biosynthetic process", "Polyol catabolic process", "Polyol metabolic process", "Polysaccharide biosynthetic process", "Polysaccharide catabolic process", "Polysaccharide metabolic process", "Pons development", "Pore complex assembly", "Porphyrin containing compound metabolic process", "Positive chemotaxis", "Positive regulation by host of viral genome replication", "Positive regulation by host of viral process", "Positive regulation by host of viral transcription", "Positive regulation by symbiont of entry into host", "Positive regulation of 3 utr mediated mrna stabilization", "Positive regulation of actin cytoskeleton reorganization", "Positive regulation of actin filament bundle assembly", "Positive regulation of actin filament depolymerization", "Positive regulation of actin filament polymerization", "Positive regulation of actin nucleation", "Positive regulation of action potential", "Positive regulation of activated t cell proliferation", "Positive regulation of activin receptor signaling pathway", "Positive regulation of acute inflammatory response", "Positive regulation of acute inflammatory response to antigenic stimulus", "Positive regulation of adaptive immune response", "Positive regulation of adipose tissue development", "Positive regulation of alcohol biosynthetic process", "Positive regulation of alpha beta t cell activation", "Positive regulation of alpha beta t cell differentiation", "Positive regulation of alpha beta t cell proliferation", "Positive regulation of amine transport", "Positive regulation of amino acid transport", "Positive regulation of amyloid beta clearance", "Positive regulation of amyloid beta formation", "Positive regulation of amyloid precursor protein biosynthetic process", "Positive regulation of amyloid precursor protein catabolic process", "Positive regulation of animal organ morphogenesis", "Positive regulation of anion transmembrane transport", "Positive regulation of anion transport", "Positive regulation of anoikis", "Positive regulation of antigen receptor mediated signaling pathway", "Positive regulation of apoptotic signaling pathway", "Positive regulation of arp2 3 complex mediated actin nucleation", "Positive regulation of aspartic type peptidase activity", "Positive regulation of astrocyte differentiation", "Positive regulation of atp biosynthetic process", "Positive regulation of atp dependent activity", "Positive regulation of atp metabolic process", "Positive regulation of atpase coupled calcium transmembrane transporter activity", "Positive regulation of attachment of spindle microtubules to kinetochore", "Positive regulation of autophagy", "Positive regulation of autophagy of mitochondrion", "Positive regulation of axon extension", "Positive regulation of axonogenesis", "Positive regulation of b cell activation", "Positive regulation of b cell differentiation", "Positive regulation of b cell mediated immunity", "Positive regulation of b cell proliferation", "Positive regulation of basement membrane assembly involved in embryonic body morphogenesis", "Positive regulation of behavior", "Positive regulation of binding", "Positive regulation of biomineralization", "Positive regulation of blood brain barrier permeability", "Positive regulation of blood circulation", "Positive regulation of blood pressure", "Positive regulation of blood pressure by epinephrine norepinephrine", "Positive regulation of blood vessel endothelial cell migration", "Positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis", "Positive regulation of bmp signaling pathway", "Positive regulation of bone mineralization", "Positive regulation of bone resorption", "Positive regulation of brown fat cell differentiation", "Positive regulation of calcineurin mediated signaling", "Positive regulation of calcium ion import", "Positive regulation of calcium ion transmembrane transport", "Positive regulation of calcium ion transmembrane transporter activity", "Positive regulation of calcium ion transport", "Positive regulation of calcium ion transport into cytosol", "Positive regulation of calcium mediated signaling", "Positive regulation of camp dependent protein kinase activity", "Positive regulation of camp mediated signaling", "Positive regulation of canonical wnt signaling pathway", "Positive regulation of carbohydrate metabolic process", "Positive regulation of cardiac muscle cell proliferation", "Positive regulation of cardioblast differentiation", "Positive regulation of cardiocyte differentiation", "Positive regulation of cartilage development", "Positive regulation of catabolic process", "Positive regulation of catalytic activity", "Positive regulation of catecholamine metabolic process", "Positive regulation of cation channel activity", "Positive regulation of cd4 positive alpha beta t cell activation", "Positive regulation of cd4 positive alpha beta t cell differentiation", "Positive regulation of cd8 positive alpha beta t cell activation", "Positive regulation of cell activation", "Positive regulation of cell adhesion", "Positive regulation of cell adhesion molecule production", "Positive regulation of cell aging", "Positive regulation of cell cell adhesion", "Positive regulation of cell cell adhesion mediated by cadherin", "Positive regulation of cell cycle", "Positive regulation of cell cycle checkpoint", "Positive regulation of cell cycle g1 s phase transition", "Positive regulation of cell cycle g2 m phase transition", "Positive regulation of cell cycle phase transition", "Positive regulation of cell cycle process", "Positive regulation of cell death", "Positive regulation of cell development", "Positive regulation of cell differentiation", "Positive regulation of cell division", "Positive regulation of cell growth", "Positive regulation of cell growth involved in cardiac muscle cell development", "Positive regulation of cell junction assembly", "Positive regulation of cell killing", "Positive regulation of cell matrix adhesion", "Positive regulation of cell maturation", "Positive regulation of cell migration by vascular endothelial growth factor signaling pathway", "Positive regulation of cell migration involved in sprouting angiogenesis", "Positive regulation of cell morphogenesis involved in differentiation", "Positive regulation of cell population proliferation", "Positive regulation of cell projection organization", "Positive regulation of cell size", "Positive regulation of cell substrate adhesion", "Positive regulation of cell substrate junction organization", "Positive regulation of cellular amide metabolic process", "Positive regulation of cellular amine metabolic process", "Positive regulation of cellular biosynthetic process", "Positive regulation of cellular carbohydrate metabolic process", "Positive regulation of cellular component biogenesis", "Positive regulation of cellular component organization", "Positive regulation of cellular extravasation", "Positive regulation of cellular ph reduction", "Positive regulation of cellular protein catabolic process", "Positive regulation of cellular respiration", "Positive regulation of cellular response to insulin stimulus", "Positive regulation of cellular response to transforming growth factor beta stimulus", "Positive regulation of centriole elongation", "Positive regulation of centriole replication", "Positive regulation of chemokine c c motif ligand 5 production", "Positive regulation of chemokine c x c motif ligand 2 production", "Positive regulation of chemokine production", "Positive regulation of chemotaxis", "Positive regulation of cholesterol biosynthetic process", "Positive regulation of cholesterol efflux", "Positive regulation of cholesterol metabolic process", "Positive regulation of cholesterol storage", "Positive regulation of chondrocyte differentiation", "Positive regulation of chromatin binding", "Positive regulation of chromatin organization", "Positive regulation of chromosome condensation", "Positive regulation of chromosome organization", "Positive regulation of chromosome segregation", "Positive regulation of chromosome separation", "Positive regulation of cilium assembly", "Positive regulation of circadian rhythm", "Positive regulation of clathrin dependent endocytosis", "Positive regulation of coagulation", "Positive regulation of cold induced thermogenesis", "Positive regulation of collagen metabolic process", "Positive regulation of collateral sprouting", "Positive regulation of complement activation", "Positive regulation of connective tissue replacement", "Positive regulation of cyclase activity", "Positive regulation of cyclic nucleotide phosphodiesterase activity", "Positive regulation of cyclin dependent protein kinase activity", "Positive regulation of cysteine type endopeptidase activity", "Positive regulation of cysteine type endopeptidase activity involved in apoptotic signaling pathway", "Positive regulation of cytokine production", "Positive regulation of cytokine production involved in immune response", "Positive regulation of cytokine production involved in inflammatory response", "Positive regulation of cytokinesis", "Positive regulation of cytoplasmic translation", "Positive regulation of cytoplasmic transport", "Positive regulation of cytoskeleton organization", "Positive regulation of defense response", "Positive regulation of defense response to virus by host", "Positive regulation of dendrite development", "Positive regulation of dendrite morphogenesis", "Positive regulation of dendritic cell cytokine production", "Positive regulation of dendritic cell differentiation", "Positive regulation of dendritic spine development", "Positive regulation of dendritic spine morphogenesis", "Positive regulation of deoxyribonuclease activity", "Positive regulation of dephosphorylation", "Positive regulation of developmental growth", "Positive regulation of developmental process", "Positive regulation of dna binding", "Positive regulation of dna binding transcription factor activity", "Positive regulation of dna biosynthetic process", "Positive regulation of dna damage response signal transduction by p53 class mediator", "Positive regulation of dna demethylation", "Positive regulation of dna dependent dna replication", "Positive regulation of dna ligation", "Positive regulation of dna metabolic process", "Positive regulation of dna methylation dependent heterochromatin assembly", "Positive regulation of dna recombination", "Positive regulation of dna repair", "Positive regulation of dna replication", "Positive regulation of dna templated transcription elongation", "Positive regulation of dna templated transcription initiation", "Positive regulation of dopamine receptor signaling pathway", "Positive regulation of double strand break repair", "Positive regulation of double strand break repair via homologous recombination", "Positive regulation of double strand break repair via nonhomologous end joining", "Positive regulation of early endosome to late endosome transport", "Positive regulation of embryonic development", "Positive regulation of endocytic recycling", "Positive regulation of endocytosis", "Positive regulation of endoplasmic reticulum stress induced intrinsic apoptotic signaling pathway", "Positive regulation of endoplasmic reticulum unfolded protein response", "Positive regulation of endothelial cell apoptotic process", "Positive regulation of endothelial cell chemotaxis", "Positive regulation of endothelial cell chemotaxis by vegf activated vascular endothelial growth factor receptor signaling pathway", "Positive regulation of endothelial cell development", "Positive regulation of endothelial cell differentiation", "Positive regulation of endothelial cell migration", "Positive regulation of endothelial cell proliferation", "Positive regulation of epidermal cell differentiation", "Positive regulation of epidermis development", "Positive regulation of epithelial cell apoptotic process", "Positive regulation of epithelial cell differentiation", "Positive regulation of epithelial cell migration", "Positive regulation of epithelial cell proliferation", "Positive regulation of epithelial cell proliferation involved in lung morphogenesis", "Positive regulation of epithelial to mesenchymal transition", "Positive regulation of er associated ubiquitin dependent protein catabolic process", "Positive regulation of erad pathway", "Positive regulation of erbb signaling pathway", "Positive regulation of erk1 and erk2 cascade", "Positive regulation of erythrocyte differentiation", "Positive regulation of establishment of protein localization", "Positive regulation of establishment of protein localization to mitochondrion", "Positive regulation of establishment of protein localization to telomere", "Positive regulation of excitatory postsynaptic potential", "Positive regulation of execution phase of apoptosis", "Positive regulation of exocytosis", "Positive regulation of exosomal secretion", "Positive regulation of extracellular matrix assembly", "Positive regulation of extracellular matrix disassembly", "Positive regulation of extracellular matrix organization", "Positive regulation of extrinsic apoptotic signaling pathway", "Positive regulation of extrinsic apoptotic signaling pathway in absence of ligand", "Positive regulation of extrinsic apoptotic signaling pathway via death domain receptors", "Positive regulation of fat cell differentiation", "Positive regulation of fatty acid beta oxidation", "Positive regulation of fatty acid biosynthetic process", "Positive regulation of fatty acid metabolic process", "Positive regulation of fatty acid oxidation", "Positive regulation of fatty acid transport", "Positive regulation of feeding behavior", "Positive regulation of fibroblast growth factor receptor signaling pathway", "Positive regulation of fibroblast migration", "Positive regulation of fibroblast proliferation", "Positive regulation of filopodium assembly", "Positive regulation of focal adhesion assembly", "Positive regulation of g protein coupled receptor signaling pathway", "Positive regulation of g0 to g1 transition", "Positive regulation of g1 s transition of mitotic cell cycle", "Positive regulation of gastrulation", "Positive regulation of gene expression", "Positive regulation of glial cell differentiation", "Positive regulation of glial cell migration", "Positive regulation of glial cell proliferation", "Positive regulation of gliogenesis", "Positive regulation of glucokinase activity", "Positive regulation of gluconeogenesis", "Positive regulation of glucose import", "Positive regulation of glucose metabolic process", "Positive regulation of glucose transmembrane transport", "Positive regulation of glutamate secretion", "Positive regulation of glycogen metabolic process", "Positive regulation of glycogen starch synthase activity", "Positive regulation of glycolytic process", "Positive regulation of glycoprotein metabolic process", "Positive regulation of golgi to plasma membrane protein transport", "Positive regulation of gonad development", "Positive regulation of granulocyte chemotaxis", "Positive regulation of growth", "Positive regulation of gtpase activity", "Positive regulation of hair follicle development", "Positive regulation of heart growth", "Positive regulation of heart rate", "Positive regulation of helicase activity", "Positive regulation of hematopoietic progenitor cell differentiation", "Positive regulation of hematopoietic stem cell proliferation", "Positive regulation of hemopoiesis", "Positive regulation of hepatocyte proliferation", "Positive regulation of heterotypic cell cell adhesion", "Positive regulation of hexokinase activity", "Positive regulation of hippo signaling", "Positive regulation of histone acetylation", "Positive regulation of histone deacetylation", "Positive regulation of histone h3 k27 methylation", "Positive regulation of histone h3 k4 methylation", "Positive regulation of histone h3 k9 acetylation", "Positive regulation of histone h3 k9 methylation", "Positive regulation of histone h4 acetylation", "Positive regulation of histone methylation", "Positive regulation of histone modification", "Positive regulation of histone phosphorylation", "Positive regulation of histone ubiquitination", "Positive regulation of homotypic cell cell adhesion", "Positive regulation of hormone biosynthetic process", "Positive regulation of hormone metabolic process", "Positive regulation of hormone secretion", "Positive regulation of humoral immune response", "Positive regulation of hydrogen peroxide metabolic process", "Positive regulation of hydrolase activity", "Positive regulation of i kappab kinase nf kappab signaling", "Positive regulation of i kappab phosphorylation", "Positive regulation of immune effector process", "Positive regulation of immune response", "Positive regulation of immune system process", "Positive regulation of immunoglobulin production", "Positive regulation of inclusion body assembly", "Positive regulation of inflammatory response", "Positive regulation of inflammatory response to antigenic stimulus", "Positive regulation of innate immune response", "Positive regulation of insulin secretion", "Positive regulation of insulin secretion involved in cellular response to glucose stimulus", "Positive regulation of integrin activation", "Positive regulation of integrin mediated signaling pathway", "Positive regulation of interferon alpha production", "Positive regulation of interferon beta production", "Positive regulation of interferon gamma production", "Positive regulation of interleukin 1 alpha production", "Positive regulation of interleukin 1 beta production", "Positive regulation of interleukin 1 production", "Positive regulation of interleukin 10 production", "Positive regulation of interleukin 12 production", "Positive regulation of interleukin 17 production", "Positive regulation of interleukin 18 production", "Positive regulation of interleukin 2 production", "Positive regulation of interleukin 6 production", "Positive regulation of interleukin 8 production", "Positive regulation of intracellular lipid transport", "Positive regulation of intracellular protein transport", "Positive regulation of intracellular signal transduction", "Positive regulation of intracellular steroid hormone receptor signaling pathway", "Positive regulation of intracellular transport", "Positive regulation of intrinsic apoptotic signaling pathway", "Positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator", "Positive regulation of intrinsic apoptotic signaling pathway in response to dna damage", "Positive regulation of ion transmembrane transport", "Positive regulation of ion transport", "Positive regulation of ire1 mediated unfolded protein response", "Positive regulation of isotype switching", "Positive regulation of isotype switching to iga isotypes", "Positive regulation of isotype switching to igg isotypes", "Positive regulation of jnk cascade", "Positive regulation of jun kinase activity", "Positive regulation of keratinocyte differentiation", "Positive regulation of keratinocyte proliferation", "Positive regulation of kinase activity", "Positive regulation of lamellipodium assembly", "Positive regulation of lamellipodium morphogenesis", "Positive regulation of lamellipodium organization", "Positive regulation of leukocyte adhesion to vascular endothelial cell", "Positive regulation of leukocyte apoptotic process", "Positive regulation of leukocyte cell cell adhesion", "Positive regulation of leukocyte chemotaxis", "Positive regulation of leukocyte degranulation", "Positive regulation of leukocyte mediated immunity", "Positive regulation of leukocyte migration", "Positive regulation of leukocyte proliferation", "Positive regulation of ligase activity", "Positive regulation of lipase activity", "Positive regulation of lipid biosynthetic process", "Positive regulation of lipid catabolic process", "Positive regulation of lipid kinase activity", "Positive regulation of lipid localization", "Positive regulation of lipid metabolic process", "Positive regulation of lipid storage", "Positive regulation of lipid transport", "Positive regulation of lipopolysaccharide mediated signaling pathway", "Positive regulation of lipoprotein particle clearance", "Positive regulation of locomotion", "Positive regulation of long term synaptic depression", "Positive regulation of long term synaptic potentiation", "Positive regulation of low density lipoprotein receptor activity", "Positive regulation of lyase activity", "Positive regulation of lymphocyte anergy", "Positive regulation of lymphocyte apoptotic process", "Positive regulation of lymphocyte chemotaxis", "Positive regulation of lymphocyte differentiation", "Positive regulation of lymphocyte mediated immunity", "Positive regulation of lymphocyte migration", "Positive regulation of macroautophagy", "Positive regulation of macrophage activation", "Positive regulation of macrophage chemotaxis", "Positive regulation of macrophage cytokine production", "Positive regulation of macrophage derived foam cell differentiation", "Positive regulation of macrophage differentiation", "Positive regulation of macrophage migration", "Positive regulation of maintenance of sister chromatid cohesion", "Positive regulation of mammary gland epithelial cell proliferation", "Positive regulation of map kinase activity", "Positive regulation of mapk cascade", "Positive regulation of mast cell activation", "Positive regulation of mast cell activation involved in immune response", "Positive regulation of megakaryocyte differentiation", "Positive regulation of meiotic cell cycle", "Positive regulation of membrane depolarization", "Positive regulation of membrane permeability", "Positive regulation of membrane potential", "Positive regulation of membrane protein ectodomain proteolysis", "Positive regulation of mesenchymal cell proliferation", "Positive regulation of mesenchymal stem cell proliferation", "Positive regulation of metalloendopeptidase activity", "Positive regulation of metallopeptidase activity", "Positive regulation of metaphase anaphase transition of cell cycle", "Positive regulation of mhc class i biosynthetic process", "Positive regulation of mhc class ii biosynthetic process", "Positive regulation of microglial cell activation", "Positive regulation of microtubule binding", "Positive regulation of microtubule nucleation", "Positive regulation of microtubule polymerization or depolymerization", "Positive regulation of mirna catabolic process", "Positive regulation of mirna mediated gene silencing by inhibition of translation", "Positive regulation of mirna metabolic process", "Positive regulation of mirna transcription", "Positive regulation of mitochondrial calcium ion concentration", "Positive regulation of mitochondrial depolarization", "Positive regulation of mitochondrial fission", "Positive regulation of mitochondrial membrane potential", "Positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway", "Positive regulation of mitochondrial translation", "Positive regulation of mitochondrion organization", "Positive regulation of mitophagy", "Positive regulation of mitophagy in response to mitochondrial depolarization", "Positive regulation of mitotic cell cycle", "Positive regulation of mitotic cell cycle phase transition", "Positive regulation of mitotic cell cycle spindle assembly checkpoint", "Positive regulation of mitotic nuclear division", "Positive regulation of molecular function", "Positive regulation of monocyte chemotaxis", "Positive regulation of monocyte differentiation", "Positive regulation of mononuclear cell migration", "Positive regulation of monooxygenase activity", "Positive regulation of morphogenesis of an epithelium", "Positive regulation of mrna 3 end processing", "Positive regulation of mrna metabolic process", "Positive regulation of mrna processing", "Positive regulation of mrna splicing via spliceosome", "Positive regulation of multicellular organism growth", "Positive regulation of multicellular organismal process", "Positive regulation of muscle cell apoptotic process", "Positive regulation of muscle cell differentiation", "Positive regulation of muscle contraction", "Positive regulation of muscle hypertrophy", "Positive regulation of muscle tissue development", "Positive regulation of myelination", "Positive regulation of myeloid cell apoptotic process", "Positive regulation of myeloid cell differentiation", "Positive regulation of myeloid leukocyte cytokine production involved in immune response", "Positive regulation of myeloid leukocyte differentiation", "Positive regulation of myeloid leukocyte mediated immunity", "Positive regulation of myoblast differentiation", "Positive regulation of myoblast fusion", "Positive regulation of myotube differentiation", "Positive regulation of nad p h oxidase activity", "Positive regulation of natural killer cell activation", "Positive regulation of natural killer cell mediated cytotoxicity", "Positive regulation of natural killer cell mediated immunity", "Positive regulation of necrotic cell death", "Positive regulation of nervous system development", "Positive regulation of nervous system process", "Positive regulation of neural precursor cell proliferation", "Positive regulation of neuroblast proliferation", "Positive regulation of neurogenesis", "Positive regulation of neuroinflammatory response", "Positive regulation of neuron apoptotic process", "Positive regulation of neuron death", "Positive regulation of neuron differentiation", "Positive regulation of neuron migration", "Positive regulation of neuron projection arborization", "Positive regulation of neuron projection development", "Positive regulation of neuron projection regeneration", "Positive regulation of neurotransmitter secretion", "Positive regulation of neurotransmitter transport", "Positive regulation of neurotransmitter uptake", "Positive regulation of neurotrophin trk receptor signaling pathway", "Positive regulation of neutrophil migration", "Positive regulation of nf kappab transcription factor activity", "Positive regulation of nik nf kappab signaling", "Positive regulation of nitric oxide metabolic process", "Positive regulation of nitric oxide synthase activity", "Positive regulation of nitric oxide synthase biosynthetic process", "Positive regulation of nk t cell activation", "Positive regulation of nlrp3 inflammasome complex assembly", "Positive regulation of non motile cilium assembly", "Positive regulation of notch signaling pathway", "Positive regulation of nuclear cell cycle dna replication", "Positive regulation of nuclear division", "Positive regulation of nuclear transcribed mrna catabolic process deadenylation dependent decay", "Positive regulation of nuclease activity", "Positive regulation of nucleobase containing compound metabolic process", "Positive regulation of nucleobase containing compound transport", "Positive regulation of nucleocytoplasmic transport", "Positive regulation of nucleotide binding oligomerization domain containing 2 signaling pathway", "Positive regulation of nucleotide binding oligomerization domain containing signaling pathway", "Positive regulation of nucleotide biosynthetic process", "Positive regulation of nucleotide metabolic process", "Positive regulation of oligodendrocyte differentiation", "Positive regulation of organ growth", "Positive regulation of organelle assembly", "Positive regulation of organelle organization", "Positive regulation of organic acid transport", "Positive regulation of ossification", "Positive regulation of osteoblast differentiation", "Positive regulation of oxidative stress induced cell death", "Positive regulation of oxidative stress induced intrinsic apoptotic signaling pathway", "Positive regulation of oxidative stress induced neuron death", "Positive regulation of oxidoreductase activity", "Positive regulation of p38mapk cascade", "Positive regulation of pathway restricted smad protein phosphorylation", "Positive regulation of pattern recognition receptor signaling pathway", "Positive regulation of peptidase activity", "Positive regulation of peptide secretion", "Positive regulation of peptidyl lysine acetylation", "Positive regulation of peptidyl serine phosphorylation", "Positive regulation of peptidyl threonine phosphorylation", "Positive regulation of peptidyl tyrosine phosphorylation", "Positive regulation of peroxisome proliferator activated receptor signaling pathway", "Positive regulation of phagocytosis", "Positive regulation of phosphatase activity", "Positive regulation of phosphatidylinositol 3 kinase signaling", "Positive regulation of phospholipase a2 activity", "Positive regulation of phospholipase activity", "Positive regulation of phospholipid biosynthetic process", "Positive regulation of phospholipid metabolic process", "Positive regulation of phosphoprotein phosphatase activity", "Positive regulation of phosphorus metabolic process", "Positive regulation of pinocytosis", "Positive regulation of plasma membrane bounded cell projection assembly", "Positive regulation of plasminogen activation", "Positive regulation of platelet aggregation", "Positive regulation of podosome assembly", "Positive regulation of posttranscriptional gene silencing", "Positive regulation of potassium ion import across plasma membrane", "Positive regulation of potassium ion transmembrane transporter activity", "Positive regulation of potassium ion transport", "Positive regulation of production of mirnas involved in gene silencing by mirna", "Positive regulation of production of molecular mediator of immune response", "Positive regulation of programmed necrotic cell death", "Positive regulation of prostaglandin biosynthetic process", "Positive regulation of proteasomal ubiquitin dependent protein catabolic process", "Positive regulation of protein acetylation", "Positive regulation of protein autophosphorylation", "Positive regulation of protein binding", "Positive regulation of protein catabolic process", "Positive regulation of protein catabolic process in the vacuole", "Positive regulation of protein containing complex assembly", "Positive regulation of protein containing complex disassembly", "Positive regulation of protein deacetylation", "Positive regulation of protein dephosphorylation", "Positive regulation of protein depolymerization", "Positive regulation of protein deubiquitination", "Positive regulation of protein exit from endoplasmic reticulum", "Positive regulation of protein export from nucleus", "Positive regulation of protein glycosylation", "Positive regulation of protein import", "Positive regulation of protein k63 linked ubiquitination", "Positive regulation of protein kinase a signaling", "Positive regulation of protein kinase activity", "Positive regulation of protein kinase b signaling", "Positive regulation of protein localization", "Positive regulation of protein localization to cell cortex", "Positive regulation of protein localization to cell periphery", "Positive regulation of protein localization to cell surface", "Positive regulation of protein localization to centrosome", "Positive regulation of protein localization to cilium", "Positive regulation of protein localization to early endosome", "Positive regulation of protein localization to membrane", "Positive regulation of protein localization to nucleus", "Positive regulation of protein maturation", "Positive regulation of protein metabolic process", "Positive regulation of protein modification by small protein conjugation or removal", "Positive regulation of protein modification process", "Positive regulation of protein monoubiquitination", "Positive regulation of protein neddylation", "Positive regulation of protein phosphorylation", "Positive regulation of protein polymerization", "Positive regulation of protein polyubiquitination", "Positive regulation of protein secretion", "Positive regulation of protein serine threonine kinase activity", "Positive regulation of protein sumoylation", "Positive regulation of protein targeting to membrane", "Positive regulation of protein tyrosine kinase activity", "Positive regulation of proteolysis", "Positive regulation of proteolysis involved in cellular protein catabolic process", "Positive regulation of pseudopodium assembly", "Positive regulation of reactive oxygen species biosynthetic process", "Positive regulation of reactive oxygen species metabolic process", "Positive regulation of receptor binding", "Positive regulation of receptor catabolic process", "Positive regulation of receptor clustering", "Positive regulation of receptor internalization", "Positive regulation of receptor mediated endocytosis", "Positive regulation of receptor recycling", "Positive regulation of receptor signaling pathway via stat", "Positive regulation of regulated secretory pathway", "Positive regulation of release of cytochrome c from mitochondria", "Positive regulation of release of sequestered calcium ion into cytosol", "Positive regulation of renal sodium excretion", "Positive regulation of reproductive process", "Positive regulation of respiratory burst", "Positive regulation of response to biotic stimulus", "Positive regulation of response to cytokine stimulus", "Positive regulation of response to dna damage stimulus", "Positive regulation of response to endoplasmic reticulum stress", "Positive regulation of response to external stimulus", "Positive regulation of response to interferon gamma", "Positive regulation of response to oxidative stress", "Positive regulation of response to reactive oxygen species", "Positive regulation of response to tumor cell", "Positive regulation of response to wounding", "Positive regulation of retinoic acid receptor signaling pathway", "Positive regulation of rho protein signal transduction", "Positive regulation of rig i signaling pathway", "Positive regulation of rna binding", "Positive regulation of rna export from nucleus", "Positive regulation of rna metabolic process", "Positive regulation of rna polymerase ii transcription preinitiation complex assembly", "Positive regulation of rna splicing", "Positive regulation of rrna processing", "Positive regulation of ruffle assembly", "Positive regulation of ryanodine sensitive calcium release channel activity", "Positive regulation of secondary metabolite biosynthetic process", "Positive regulation of secretion", "Positive regulation of sequestering of calcium ion", "Positive regulation of sequestering of triglyceride", "Positive regulation of signal transduction by p53 class mediator", "Positive regulation of signaling", "Positive regulation of signaling receptor activity", "Positive regulation of sister chromatid cohesion", "Positive regulation of skeletal muscle tissue development", "Positive regulation of smad protein signal transduction", "Positive regulation of small gtpase mediated signal transduction", "Positive regulation of small molecule metabolic process", "Positive regulation of smooth muscle cell apoptotic process", "Positive regulation of smooth muscle cell differentiation", "Positive regulation of smooth muscle cell migration", "Positive regulation of smooth muscle cell proliferation", "Positive regulation of smooth muscle contraction", "Positive regulation of smoothened signaling pathway", "Positive regulation of sodium ion transmembrane transport", "Positive regulation of sodium ion transmembrane transporter activity", "Positive regulation of sodium ion transport", "Positive regulation of spindle assembly", "Positive regulation of sprouting angiogenesis", "Positive regulation of stem cell differentiation", "Positive regulation of stem cell proliferation", "Positive regulation of steroid biosynthetic process", "Positive regulation of steroid hormone biosynthetic process", "Positive regulation of steroid metabolic process", "Positive regulation of sterol transport", "Positive regulation of stress activated protein kinase signaling cascade", "Positive regulation of stress fiber assembly", "Positive regulation of striated muscle cell apoptotic process", "Positive regulation of striated muscle cell differentiation", "Positive regulation of striated muscle contraction", "Positive regulation of substrate adhesion dependent cell spreading", "Positive regulation of supramolecular fiber organization", "Positive regulation of synapse assembly", "Positive regulation of synaptic plasticity", "Positive regulation of synaptic transmission", "Positive regulation of synaptic transmission gabaergic", "Positive regulation of synaptic transmission glutamatergic", "Positive regulation of synaptic vesicle endocytosis", "Positive regulation of synaptic vesicle recycling", "Positive regulation of syncytium formation by plasma membrane fusion", "Positive regulation of systemic arterial blood pressure", "Positive regulation of t cell apoptotic process", "Positive regulation of t cell cytokine production", "Positive regulation of t cell differentiation in thymus", "Positive regulation of t cell mediated cytotoxicity", "Positive regulation of t cell mediated immune response to tumor cell", "Positive regulation of t cell mediated immunity", "Positive regulation of t cell migration", "Positive regulation of t cell proliferation", "Positive regulation of t cell receptor signaling pathway", "Positive regulation of t cell tolerance induction", "Positive regulation of t helper 1 cell differentiation", "Positive regulation of t helper cell differentiation", "Positive regulation of tau protein kinase activity", "Positive regulation of telomerase activity", "Positive regulation of telomerase rna localization to cajal body", "Positive regulation of telomere capping", "Positive regulation of telomere maintenance", "Positive regulation of telomere maintenance via telomere lengthening", "Positive regulation of tissue remodeling", "Positive regulation of tolerance induction", "Positive regulation of toll like receptor 3 signaling pathway", "Positive regulation of toll like receptor 9 signaling pathway", "Positive regulation of toll like receptor signaling pathway", "Positive regulation of tor signaling", "Positive regulation of torc1 signaling", "Positive regulation of transcription by rna polymerase i", "Positive regulation of transcription by rna polymerase ii", "Positive regulation of transcription by rna polymerase iii", "Positive regulation of transcription elongation from rna polymerase ii promoter", "Positive regulation of transcription from rna polymerase ii promoter in response to endoplasmic reticulum stress", "Positive regulation of transcription from rna polymerase ii promoter in response to hypoxia", "Positive regulation of transcription from rna polymerase ii promoter in response to stress", "Positive regulation of transcription from rna polymerase ii promoter involved in cellular response to chemical stimulus", "Positive regulation of transcription of nucleolar large rrna by rna polymerase i", "Positive regulation of transcription regulatory region dna binding", "Positive regulation of transferase activity", "Positive regulation of translation", "Positive regulation of translation in response to endoplasmic reticulum stress", "Positive regulation of translation in response to stress", "Positive regulation of translational initiation", "Positive regulation of transmembrane receptor protein serine threonine kinase signaling pathway", "Positive regulation of transmembrane transport", "Positive regulation of transmission of nerve impulse", "Positive regulation of transport", "Positive regulation of transporter activity", "Positive regulation of triglyceride biosynthetic process", "Positive regulation of triglyceride catabolic process", "Positive regulation of triglyceride metabolic process", "Positive regulation of trophoblast cell migration", "Positive regulation of tumor necrosis factor mediated signaling pathway", "Positive regulation of tumor necrosis factor superfamily cytokine production", "Positive regulation of type i interferon mediated signaling pathway", "Positive regulation of type i interferon production", "Positive regulation of tyrosine phosphorylation of stat protein", "Positive regulation of ubiquitin dependent protein catabolic process", "Positive regulation of ubiquitin protein ligase activity", "Positive regulation of ubiquitin protein transferase activity", "Positive regulation of unsaturated fatty acid biosynthetic process", "Positive regulation of urine volume", "Positive regulation of vacuole organization", "Positive regulation of vascular associated smooth muscle cell apoptotic process", "Positive regulation of vascular associated smooth muscle cell differentiation", "Positive regulation of vascular associated smooth muscle cell migration", "Positive regulation of vascular associated smooth muscle cell proliferation", "Positive regulation of vascular endothelial cell proliferation", "Positive regulation of vascular permeability", "Positive regulation of vasculature development", "Positive regulation of vasculogenesis", "Positive regulation of vasoconstriction", "Positive regulation of vesicle fusion", "Positive regulation of viral genome replication", "Positive regulation of viral life cycle", "Positive regulation of viral process", "Positive regulation of vitamin d receptor signaling pathway", "Positive regulation of voltage gated calcium channel activity", "Positive regulation of wnt signaling pathway", "Positive regulation of wound healing", "Positive regulation of wound healing spreading of epidermal cells", "Positive t cell selection", "Post anal tail morphogenesis", "Post chaperonin tubulin folding pathway", "Post embryonic animal morphogenesis", "Post embryonic animal organ development", "Post embryonic animal organ morphogenesis", "Post embryonic camera type eye development", "Post embryonic development", "Post embryonic eye morphogenesis", "Post golgi vesicle mediated transport", "Post translational protein modification", "Postreplication repair", "Postsynapse organization", "Postsynapse to nucleus signaling pathway", "Postsynaptic actin cytoskeleton organization", "Postsynaptic cytoskeleton organization", "Postsynaptic membrane organization", "Postsynaptic modulation of chemical synaptic transmission", "Postsynaptic neurotransmitter receptor internalization", "Postsynaptic signal transduction", "Postsynaptic specialization organization", "Posttranscriptional regulation of gene expression", "Posttranslational protein targeting to endoplasmic reticulum membrane", "Posttranslational protein targeting to membrane translocation", "Potassium ion homeostasis", "Potassium ion import across plasma membrane", "Potassium ion transport", "Pre mirna processing", "Prenylation", "Presynapse organization", "Presynaptic active zone organization", "Presynaptic endocytosis", "Presynaptic modulation of chemical synaptic transmission", "Prevention of polyspermy", "Primary alcohol biosynthetic process", "Primary alcohol catabolic process", "Primary alcohol metabolic process", "Primary amino compound biosynthetic process", "Primary amino compound metabolic process", "Primary mirna processing", "Primitive hemopoiesis", "Pro b cell differentiation", "Process utilizing autophagic mechanism", "Production of molecular mediator involved in inflammatory response", "Production of molecular mediator of immune response", "Production of sirna involved in rna interference", "Progesterone biosynthetic process", "Progesterone metabolic process", "Progesterone receptor signaling pathway", "Programmed cell death", "Programmed cell death in response to reactive oxygen species", "Programmed cell death involved in cell development", "Programmed necrotic cell death", "Prolactin secretion", "Proline metabolic process", "Pronephros development", "Proprioception", "Prostaglandin transport", "Prostanoid biosynthetic process", "Prostanoid metabolic process", "Prostate gland development", "Prostate gland growth", "Prosthetic group metabolic process", "Proteasomal protein catabolic process", "Proteasome assembly", "Proteasome mediated ubiquitin dependent protein catabolic process", "Protection from natural killer cell mediated cytotoxicity", "Protection from non homologous end joining at telomere", "Protein acetylation", "Protein activation cascade", "Protein acylation", "Protein adp ribosylation", "Protein auto adp ribosylation", "Protein autophosphorylation", "Protein autoprocessing", "Protein autoubiquitination", "Protein catabolic process", "Protein catabolic process in the vacuole", "Protein complex oligomerization", "Protein containing complex disassembly", "Protein containing complex localization", "Protein containing complex organization", "Protein containing complex remodeling", "Protein de adp ribosylation", "Protein deglycosylation", "Protein demannosylation", "Protein demethylation", "Protein deneddylation", "Protein depalmitoylation", "Protein dephosphorylation", "Protein depolymerization", "Protein destabilization", "Protein desumoylation", "Protein deubiquitination involved in ubiquitin dependent protein catabolic process", "Protein dna complex assembly", "Protein dna complex disassembly", "Protein dna complex subunit organization", "Protein dna covalent cross linking repair", "Protein exit from endoplasmic reticulum", "Protein export from nucleus", "Protein folding", "Protein folding in endoplasmic reticulum", "Protein geranylgeranylation", "Protein heterooligomerization", "Protein heterotetramerization", "Protein hexamerization", "Protein homooligomerization", "Protein homotetramerization", "Protein hydroxylation", "Protein import", "Protein import into mitochondrial matrix", "Protein import into peroxisome matrix", "Protein import into peroxisome membrane", "Protein insertion into er membrane", "Protein insertion into er membrane by stop transfer membrane anchor sequence", "Protein insertion into membrane", "Protein insertion into mitochondrial inner membrane", "Protein insertion into mitochondrial membrane involved in apoptotic signaling pathway", "Protein k11 linked ubiquitination", "Protein k27 linked ubiquitination", "Protein k29 linked ubiquitination", "Protein k48 linked deubiquitination", "Protein k48 linked ubiquitination", "Protein k6 linked ubiquitination", "Protein k63 linked deubiquitination", "Protein k63 linked ubiquitination", "Protein kinase a signaling", "Protein kinase b signaling", "Protein kinase c signaling", "Protein lipid complex assembly", "Protein lipid complex subunit organization", "Protein localization to adherens junction", "Protein localization to axon", "Protein localization to basolateral plasma membrane", "Protein localization to cell cell junction", "Protein localization to cell cortex", "Protein localization to cell junction", "Protein localization to cell periphery", "Protein localization to cell surface", "Protein localization to chromatin", "Protein localization to chromosome", "Protein localization to chromosome centromeric region", "Protein localization to chromosome telomeric region", "Protein localization to ciliary membrane", "Protein localization to cilium", "Protein localization to condensed chromosome", "Protein localization to cytoplasmic stress granule", "Protein localization to cytoskeleton", "Protein localization to early endosome", "Protein localization to endoplasmic reticulum", "Protein localization to endoplasmic reticulum exit site", "Protein localization to endosome", "Protein localization to extracellular region", "Protein localization to golgi apparatus", "Protein localization to lysosome", "Protein localization to membrane raft", "Protein localization to microtubule", "Protein localization to microtubule end", "Protein localization to microtubule organizing center", "Protein localization to mitochondrion", "Protein localization to nuclear body", "Protein localization to nuclear envelope", "Protein localization to nucleolus", "Protein localization to nucleoplasm", "Protein localization to nucleus", "Protein localization to organelle", "Protein localization to perinuclear region of cytoplasm", "Protein localization to phagophore assembly site", "Protein localization to plasma membrane", "Protein localization to postsynapse", "Protein localization to presynapse", "Protein localization to synapse", "Protein localization to vacuole", "Protein mannosylation", "Protein maturation", "Protein maturation by 4fe 4s cluster transfer", "Protein maturation by iron sulfur cluster transfer", "Protein maturation by protein folding", "Protein methylation", "Protein modification by small protein conjugation", "Protein modification by small protein conjugation or removal", "Protein modification by small protein removal", "Protein monoubiquitination", "Protein n linked glycosylation", "Protein neddylation", "Protein nitrosylation", "Protein o linked fucosylation", "Protein o linked glycosylation", "Protein o linked glycosylation via serine", "Protein o linked glycosylation via threonine", "Protein o linked mannosylation", "Protein oxidation", "Protein peptidyl prolyl isomerization", "Protein poly adp ribosylation", "Protein polyglutamylation", "Protein polymerization", "Protein polyubiquitination", "Protein polyufmylation", "Protein processing", "Protein processing involved in protein targeting to mitochondrion", "Protein quality control for misfolded or incompletely synthesized proteins", "Protein refolding", "Protein repair", "Protein retention in er lumen", "Protein retention in golgi apparatus", "Protein stabilization", "Protein sumoylation", "Protein targeting", "Protein targeting to lysosome", "Protein targeting to membrane", "Protein targeting to mitochondrion", "Protein targeting to peroxisome", "Protein targeting to vacuole", "Protein tetramerization", "Protein transmembrane import into intracellular organelle", "Protein transmembrane transport", "Protein transport along microtubule", "Protein transport to vacuole involved in ubiquitin dependent protein catabolic process via the multivesicular body sorting pathway", "Protein trimerization", "Protein ufmylation", "Proteoglycan biosynthetic process", "Proteoglycan metabolic process", "Proteolysis", "Proton transmembrane transport", "Proton transporting two sector atpase complex assembly", "Proton transporting v type atpase complex assembly", "Protoporphyrinogen ix biosynthetic process", "Protoporphyrinogen ix metabolic process", "Proximal distal pattern formation", "Proximal tubule development", "Pseudopodium organization", "Pseudouridine synthesis", "Pteridine containing compound biosynthetic process", "Pteridine containing compound metabolic process", "Pulmonary artery morphogenesis", "Pulmonary valve development", "Pulmonary valve morphogenesis", "Purine containing compound biosynthetic process", "Purine containing compound catabolic process", "Purine containing compound metabolic process", "Purine containing compound salvage", "Purine containing compound transmembrane transport", "Purine deoxyribonucleoside metabolic process", "Purine deoxyribonucleoside monophosphate catabolic process", "Purine deoxyribonucleoside monophosphate metabolic process", "Purine deoxyribonucleoside triphosphate metabolic process", "Purine deoxyribonucleotide biosynthetic process", "Purine deoxyribonucleotide catabolic process", "Purine deoxyribonucleotide metabolic process", "Purine nucleobase biosynthetic process", "Purine nucleobase metabolic process", "Purine nucleoside biosynthetic process", "Purine nucleoside catabolic process", "Purine nucleoside diphosphate biosynthetic process", "Purine nucleoside diphosphate catabolic process", "Purine nucleoside metabolic process", "Purine nucleoside monophosphate biosynthetic process", "Purine nucleoside monophosphate catabolic process", "Purine nucleoside monophosphate metabolic process", "Purine nucleoside triphosphate catabolic process", "Purine nucleotide catabolic process", "Purine nucleotide salvage", "Purine nucleotide transport", "Purine ribonucleoside catabolic process", "Purine ribonucleoside metabolic process", "Purine ribonucleoside salvage", "Purine ribonucleotide salvage", "Purinergic nucleotide receptor signaling pathway", "Pyramidal neuron development", "Pyramidal neuron differentiation", "Pyridine containing compound biosynthetic process", "Pyridine containing compound catabolic process", "Pyridine containing compound metabolic process", "Pyridine nucleotide biosynthetic process", "Pyridine nucleotide metabolic process", "Pyrimidine containing compound biosynthetic process", "Pyrimidine containing compound catabolic process", "Pyrimidine containing compound metabolic process", "Pyrimidine containing compound transmembrane transport", "Pyrimidine deoxyribonucleoside metabolic process", "Pyrimidine deoxyribonucleoside monophosphate biosynthetic process", "Pyrimidine deoxyribonucleoside monophosphate metabolic process", "Pyrimidine deoxyribonucleoside triphosphate metabolic process", "Pyrimidine deoxyribonucleotide biosynthetic process", "Pyrimidine deoxyribonucleotide metabolic process", "Pyrimidine dimer repair", "Pyrimidine nucleobase biosynthetic process", "Pyrimidine nucleobase catabolic process", "Pyrimidine nucleobase metabolic process", "Pyrimidine nucleoside diphosphate biosynthetic process", "Pyrimidine nucleoside diphosphate metabolic process", "Pyrimidine nucleoside metabolic process", "Pyrimidine nucleoside monophosphate biosynthetic process", "Pyrimidine nucleoside monophosphate metabolic process", "Pyrimidine nucleoside transport", "Pyrimidine nucleoside triphosphate biosynthetic process", "Pyrimidine nucleoside triphosphate metabolic process", "Pyrimidine nucleotide catabolic process", "Pyrimidine nucleotide metabolic process", "Pyrimidine ribonucleoside diphosphate metabolic process", "Pyrimidine ribonucleoside monophosphate metabolic process", "Pyrimidine ribonucleoside triphosphate biosynthetic process", "Pyrimidine ribonucleoside triphosphate metabolic process", "Pyrimidine ribonucleotide biosynthetic process", "Pyrimidine ribonucleotide metabolic process", "Pyroptosis", "Pyruvate metabolic process", "Quaternary ammonium group transport", "Quinone metabolic process", "R loop disassembly", "Rab protein signal transduction", "Rac protein signal transduction", "Radial glial cell differentiation", "Rap protein signal transduction", "Ras protein signal transduction", "Reactive nitrogen species metabolic process", "Reactive oxygen species biosynthetic process", "Reactive oxygen species metabolic process", "Receptor catabolic process", "Receptor clustering", "Receptor diffusion trapping", "Receptor internalization", "Receptor localization to synapse", "Receptor mediated endocytosis", "Receptor mediated endocytosis involved in cholesterol transport", "Receptor metabolic process", "Receptor recycling", "Receptor signaling pathway via stat", "Recognition of apoptotic cell", "Recombinational repair", "Reelin mediated signaling pathway", "Reflex", "Regeneration", "Regionalization", "Regulated exocytosis", "Regulation by virus of viral protein levels in host cell", "Regulation of 3 utr mediated mrna stabilization", "Regulation of actin cytoskeleton reorganization", "Regulation of actin filament based movement", "Regulation of actin filament based process", "Regulation of actin filament bundle assembly", "Regulation of actin filament length", "Regulation of actin filament organization", "Regulation of actin nucleation", "Regulation of action potential", "Regulation of activin receptor signaling pathway", "Regulation of actomyosin structure organization", "Regulation of acute inflammatory response", "Regulation of acute inflammatory response to antigenic stimulus", "Regulation of acyl coa biosynthetic process", "Regulation of adaptive immune response", "Regulation of adenylate cyclase activating g protein coupled receptor signaling pathway", "Regulation of adenylate cyclase activity", "Regulation of adherens junction organization", "Regulation of adipose tissue development", "Regulation of aerobic respiration", "Regulation of alcohol biosynthetic process", "Regulation of alpha beta t cell activation", "Regulation of alpha beta t cell differentiation", "Regulation of alternative mrna splicing via spliceosome", "Regulation of amino acid transmembrane transport", "Regulation of amino acid transport", "Regulation of amyloid beta clearance", "Regulation of amyloid fibril formation", "Regulation of amyloid precursor protein catabolic process", "Regulation of anaphase promoting complex dependent catabolic process", "Regulation of anatomical structure morphogenesis", "Regulation of anatomical structure size", "Regulation of androgen receptor signaling pathway", "Regulation of animal organ formation", "Regulation of animal organ morphogenesis", "Regulation of anion channel activity", "Regulation of anion transmembrane transport", "Regulation of anion transport", "Regulation of anoikis", "Regulation of antifungal innate immune response", "Regulation of antigen receptor mediated signaling pathway", "Regulation of apoptotic cell clearance", "Regulation of apoptotic dna fragmentation", "Regulation of apoptotic process involved in development", "Regulation of apoptotic signaling pathway", "Regulation of appetite", "Regulation of arachidonic acid secretion", "Regulation of arp2 3 complex mediated actin nucleation", "Regulation of aspartic type endopeptidase activity involved in amyloid precursor protein catabolic process", "Regulation of aspartic type peptidase activity", "Regulation of astrocyte activation", "Regulation of astrocyte differentiation", "Regulation of atp biosynthetic process", "Regulation of atp dependent activity", "Regulation of atp metabolic process", "Regulation of atpase coupled calcium transmembrane transporter activity", "Regulation of atrial cardiac muscle cell membrane repolarization", "Regulation of attachment of spindle microtubules to kinetochore", "Regulation of autophagic cell death", "Regulation of autophagosome maturation", "Regulation of autophagy", "Regulation of autophagy of mitochondrion", "Regulation of autophagy of mitochondrion in response to mitochondrial depolarization", "Regulation of axon diameter", "Regulation of axon guidance", "Regulation of axonogenesis", "Regulation of b cell activation", "Regulation of b cell apoptotic process", "Regulation of b cell differentiation", "Regulation of b cell mediated immunity", "Regulation of b cell proliferation", "Regulation of barbed end actin filament capping", "Regulation of behavior", "Regulation of bicellular tight junction assembly", "Regulation of bile acid biosynthetic process", "Regulation of bile acid metabolic process", "Regulation of binding", "Regulation of biological process involved in symbiotic interaction", "Regulation of biomineralization", "Regulation of blood brain barrier permeability", "Regulation of blood circulation", "Regulation of blood pressure", "Regulation of bmp signaling pathway", "Regulation of body fluid levels", "Regulation of bone mineralization", "Regulation of bone remodeling", "Regulation of bone resorption", "Regulation of branching involved in lung morphogenesis", "Regulation of branching morphogenesis of a nerve", "Regulation of brown fat cell differentiation", "Regulation of calcidiol 1 monooxygenase activity", "Regulation of calcineurin mediated signaling", "Regulation of calcium ion dependent exocytosis", "Regulation of calcium ion export across plasma membrane", "Regulation of calcium ion import", "Regulation of calcium ion transmembrane transport", "Regulation of calcium ion transmembrane transporter activity", "Regulation of calcium ion transport", "Regulation of calcium ion transport into cytosol", "Regulation of calcium mediated signaling", "Regulation of camp dependent protein kinase activity", "Regulation of camp mediated signaling", "Regulation of canonical wnt signaling pathway", "Regulation of carbohydrate biosynthetic process", "Regulation of carbohydrate catabolic process", "Regulation of carbohydrate metabolic process", "Regulation of cardiac conduction", "Regulation of cardiac muscle adaptation", "Regulation of cardiac muscle cell action potential", "Regulation of cardiac muscle cell action potential involved in regulation of contraction", "Regulation of cardiac muscle cell membrane potential", "Regulation of cardiac muscle cell membrane repolarization", "Regulation of cardiac muscle cell proliferation", "Regulation of cardiac muscle contraction", "Regulation of cardiac muscle contraction by calcium ion signaling", "Regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion", "Regulation of cardioblast differentiation", "Regulation of cardiocyte differentiation", "Regulation of cartilage development", "Regulation of catabolic process", "Regulation of catecholamine metabolic process", "Regulation of cation channel activity", "Regulation of cation transmembrane transport", "Regulation of caveolin mediated endocytosis", "Regulation of cd4 positive alpha beta t cell activation", "Regulation of cd4 positive alpha beta t cell differentiation", "Regulation of cd8 positive alpha beta t cell activation", "Regulation of cell activation", "Regulation of cell adhesion", "Regulation of cell adhesion mediated by integrin", "Regulation of cell aging", "Regulation of cell cell adhesion", "Regulation of cell cell adhesion mediated by cadherin", "Regulation of cell cell adhesion mediated by integrin", "Regulation of cell communication by electrical coupling", "Regulation of cell communication by electrical coupling involved in cardiac conduction", "Regulation of cell cycle", "Regulation of cell cycle checkpoint", "Regulation of cell cycle g1 s phase transition", "Regulation of cell cycle g2 m phase transition", "Regulation of cell cycle phase transition", "Regulation of cell cycle process", "Regulation of cell death", "Regulation of cell development", "Regulation of cell differentiation", "Regulation of cell division", "Regulation of cell growth involved in cardiac muscle cell development", "Regulation of cell junction assembly", "Regulation of cell killing", "Regulation of cell matrix adhesion", "Regulation of cell maturation", "Regulation of cell migration involved in sprouting angiogenesis", "Regulation of cell morphogenesis", "Regulation of cell morphogenesis involved in differentiation", "Regulation of cell population proliferation", "Regulation of cell projection assembly", "Regulation of cell projection organization", "Regulation of cell projection size", "Regulation of cell shape", "Regulation of cell size", "Regulation of cell substrate adhesion", "Regulation of cell substrate junction organization", "Regulation of cellular amide metabolic process", "Regulation of cellular amine metabolic process", "Regulation of cellular amino acid metabolic process", "Regulation of cellular carbohydrate catabolic process", "Regulation of cellular carbohydrate metabolic process", "Regulation of cellular component biogenesis", "Regulation of cellular component movement", "Regulation of cellular component size", "Regulation of cellular extravasation", "Regulation of cellular ketone metabolic process", "Regulation of cellular localization", "Regulation of cellular macromolecule biosynthetic process", "Regulation of cellular ph", "Regulation of cellular ph reduction", "Regulation of cellular protein catabolic process", "Regulation of cellular respiration", "Regulation of cellular response to growth factor stimulus", "Regulation of cellular response to heat", "Regulation of cellular response to hypoxia", "Regulation of cellular response to insulin stimulus", "Regulation of cellular response to osmotic stress", "Regulation of cellular response to stress", "Regulation of cellular response to transforming growth factor beta stimulus", "Regulation of centriole replication", "Regulation of centrosome cycle", "Regulation of chaperone mediated autophagy", "Regulation of chemokine mediated signaling pathway", "Regulation of chemotaxis", "Regulation of chloride transport", "Regulation of cholesterol biosynthetic process", "Regulation of cholesterol efflux", "Regulation of cholesterol esterification", "Regulation of cholesterol metabolic process", "Regulation of chondrocyte differentiation", "Regulation of chromatin assembly", "Regulation of chromatin assembly or disassembly", "Regulation of chromatin binding", "Regulation of chromatin organization", "Regulation of chromosome condensation", "Regulation of chromosome organization", "Regulation of chromosome segregation", "Regulation of chromosome separation", "Regulation of cilium assembly", "Regulation of cilium beat frequency", "Regulation of cilium beat frequency involved in ciliary motility", "Regulation of cilium dependent cell motility", "Regulation of cilium movement", "Regulation of circadian rhythm", "Regulation of clathrin dependent endocytosis", "Regulation of coagulation", "Regulation of collagen fibril organization", "Regulation of collagen metabolic process", "Regulation of collateral sprouting", "Regulation of complement activation", "Regulation of complement dependent cytotoxicity", "Regulation of connective tissue replacement", "Regulation of core promoter binding", "Regulation of corticotropin secretion", "Regulation of cyclase activity", "Regulation of cyclic nucleotide phosphodiesterase activity", "Regulation of cyclin dependent protein kinase activity", "Regulation of cysteine type endopeptidase activity", "Regulation of cysteine type endopeptidase activity involved in apoptotic signaling pathway", "Regulation of cysteine type endopeptidase activity involved in execution phase of apoptosis", "Regulation of cytokinesis", "Regulation of cytoplasmic mrna processing body assembly", "Regulation of cytoplasmic translation", "Regulation of cytoplasmic translational elongation", "Regulation of cytoplasmic translational initiation", "Regulation of cytoplasmic transport", "Regulation of cytoskeleton organization", "Regulation of cytosolic calcium ion concentration", "Regulation of defense response", "Regulation of defense response to fungus", "Regulation of defense response to virus", "Regulation of defense response to virus by host", "Regulation of delayed rectifier potassium channel activity", "Regulation of dendrite development", "Regulation of dendrite extension", "Regulation of dendrite morphogenesis", "Regulation of dendritic cell chemotaxis", "Regulation of dendritic cell differentiation", "Regulation of dendritic spine development", "Regulation of dendritic spine maintenance", "Regulation of dendritic spine morphogenesis", "Regulation of deoxyribonuclease activity", "Regulation of dephosphorylation", "Regulation of developmental growth", "Regulation of digestive system process", "Regulation of dna binding", "Regulation of dna binding transcription factor activity", "Regulation of dna biosynthetic process", "Regulation of dna catabolic process", "Regulation of dna damage checkpoint", "Regulation of dna damage response signal transduction by p53 class mediator", "Regulation of dna damage response signal transduction by p53 class mediator resulting in transcription of p21 class mediator", "Regulation of dna demethylation", "Regulation of dna dependent dna replication", "Regulation of dna dependent dna replication initiation", "Regulation of dna directed dna polymerase activity", "Regulation of dna duplex unwinding", "Regulation of dna helicase activity", "Regulation of dna ligation", "Regulation of dna metabolic process", "Regulation of dna methylation", "Regulation of dna methylation dependent heterochromatin assembly", "Regulation of dna primase activity", "Regulation of dna recombination", "Regulation of dna repair", "Regulation of dna replication", "Regulation of dna strand elongation", "Regulation of dna templated transcription elongation", "Regulation of dna templated transcription in response to stress", "Regulation of dna templated transcription initiation", "Regulation of dna topoisomerase atp hydrolyzing activity", "Regulation of dopamine receptor signaling pathway", "Regulation of dopaminergic neuron differentiation", "Regulation of double strand break repair", "Regulation of double strand break repair via homologous recombination", "Regulation of double strand break repair via nonhomologous end joining", "Regulation of early endosome to late endosome transport", "Regulation of electron transfer activity", "Regulation of embryonic development", "Regulation of endocrine process", "Regulation of endocytic recycling", "Regulation of endocytosis", "Regulation of endodeoxyribonuclease activity", "Regulation of endodermal cell differentiation", "Regulation of endoplasmic reticulum stress induced intrinsic apoptotic signaling pathway", "Regulation of endoplasmic reticulum tubular network organization", "Regulation of endoplasmic reticulum unfolded protein response", "Regulation of endothelial cell chemotaxis", "Regulation of endothelial cell development", "Regulation of endothelial cell differentiation", "Regulation of endothelial cell migration", "Regulation of entry of bacterium into host cell", "Regulation of epidermal growth factor activated receptor activity", "Regulation of epidermis development", "Regulation of epithelial cell apoptotic process", "Regulation of epithelial cell differentiation", "Regulation of epithelial cell differentiation involved in kidney development", "Regulation of epithelial cell migration", "Regulation of epithelial cell proliferation involved in lung morphogenesis", "Regulation of epithelial to mesenchymal transition", "Regulation of er associated ubiquitin dependent protein catabolic process", "Regulation of er to golgi vesicle mediated transport", "Regulation of erad pathway", "Regulation of erbb signaling pathway", "Regulation of erythrocyte differentiation", "Regulation of establishment of planar polarity", "Regulation of establishment of protein localization", "Regulation of establishment of protein localization to chromosome", "Regulation of establishment of protein localization to mitochondrion", "Regulation of establishment or maintenance of cell polarity", "Regulation of excretion", "Regulation of execution phase of apoptosis", "Regulation of exit from mitosis", "Regulation of exocytosis", "Regulation of exosomal secretion", "Regulation of extent of cell growth", "Regulation of extracellular matrix assembly", "Regulation of extracellular matrix disassembly", "Regulation of extracellular matrix organization", "Regulation of extrinsic apoptotic signaling pathway", "Regulation of extrinsic apoptotic signaling pathway in absence of ligand", "Regulation of extrinsic apoptotic signaling pathway via death domain receptors", "Regulation of fat cell differentiation", "Regulation of fat cell proliferation", "Regulation of fatty acid beta oxidation", "Regulation of fatty acid biosynthetic process", "Regulation of fatty acid metabolic process", "Regulation of fatty acid oxidation", "Regulation of fatty acid transport", "Regulation of fc gamma receptor signaling pathway involved in phagocytosis", "Regulation of fc receptor mediated stimulatory signaling pathway", "Regulation of feeding behavior", "Regulation of fertilization", "Regulation of fibroblast growth factor receptor signaling pathway", "Regulation of fibroblast migration", "Regulation of filopodium assembly", "Regulation of focal adhesion disassembly", "Regulation of g protein coupled receptor signaling pathway", "Regulation of g0 to g1 transition", "Regulation of gamma aminobutyric acid secretion", "Regulation of gastrulation", "Regulation of gene expression by genomic imprinting", "Regulation of gene expression epigenetic", "Regulation of gene silencing by rna", "Regulation of generation of precursor metabolites and energy", "Regulation of genetic imprinting", "Regulation of germ cell proliferation", "Regulation of germinal center formation", "Regulation of glial cell apoptotic process", "Regulation of glial cell differentiation", "Regulation of glial cell migration", "Regulation of glial cell proliferation", "Regulation of gliogenesis", "Regulation of glucagon secretion", "Regulation of glucan biosynthetic process", "Regulation of glucocorticoid biosynthetic process", "Regulation of glucocorticoid metabolic process", "Regulation of glucocorticoid receptor signaling pathway", "Regulation of gluconeogenesis", "Regulation of glucose import", "Regulation of glucose metabolic process", "Regulation of glucose transmembrane transport", "Regulation of glucosylceramidase activity", "Regulation of glutamate receptor clustering", "Regulation of glutamate secretion", "Regulation of glycogen catabolic process", "Regulation of glycogen metabolic process", "Regulation of glycogen starch synthase activity", "Regulation of glycolytic process", "Regulation of glycoprotein metabolic process", "Regulation of golgi organization", "Regulation of golgi to plasma membrane protein transport", "Regulation of gonad development", "Regulation of granulocyte chemotaxis", "Regulation of granulocyte differentiation", "Regulation of growth", "Regulation of gtp binding", "Regulation of gtpase activity", "Regulation of guanyl nucleotide exchange factor activity", "Regulation of hair cycle", "Regulation of hair follicle development", "Regulation of heart contraction", "Regulation of heart growth", "Regulation of heart rate", "Regulation of heart rate by cardiac conduction", "Regulation of heart rate by chemical signal", "Regulation of helicase activity", "Regulation of hematopoietic progenitor cell differentiation", "Regulation of hematopoietic stem cell differentiation", "Regulation of hematopoietic stem cell proliferation", "Regulation of hemoglobin biosynthetic process", "Regulation of hemopoiesis", "Regulation of hepatic stellate cell activation", "Regulation of hepatocyte proliferation", "Regulation of heterotypic cell cell adhesion", "Regulation of hexokinase activity", "Regulation of high voltage gated calcium channel activity", "Regulation of hippo signaling", "Regulation of histamine secretion by mast cell", "Regulation of histone deacetylation", "Regulation of histone h2b ubiquitination", "Regulation of histone h3 k14 acetylation", "Regulation of histone h3 k27 methylation", "Regulation of histone h3 k36 methylation", "Regulation of histone h3 k4 methylation", "Regulation of histone h3 k9 methylation", "Regulation of histone h3 k9 trimethylation", "Regulation of histone h4 acetylation", "Regulation of histone h4 k16 acetylation", "Regulation of histone methylation", "Regulation of histone modification", "Regulation of histone phosphorylation", "Regulation of histone ubiquitination", "Regulation of homotypic cell cell adhesion", "Regulation of hormone biosynthetic process", "Regulation of hormone levels", "Regulation of hormone metabolic process", "Regulation of hormone secretion", "Regulation of humoral immune response", "Regulation of hyaluronan biosynthetic process", "Regulation of hydrogen peroxide biosynthetic process", "Regulation of hydrogen peroxide mediated programmed cell death", "Regulation of hydrogen peroxide metabolic process", "Regulation of hydrolase activity", "Regulation of i kappab phosphorylation", "Regulation of icosanoid secretion", "Regulation of immune effector process", "Regulation of immune response", "Regulation of immune system process", "Regulation of immunoglobulin production", "Regulation of inclusion body assembly", "Regulation of inflammatory response", "Regulation of inflammatory response to antigenic stimulus", "Regulation of innate immune response", "Regulation of inositol 1 4 5 trisphosphate sensitive calcium release channel activity", "Regulation of insulin receptor signaling pathway", "Regulation of insulin secretion", "Regulation of insulin secretion involved in cellular response to glucose stimulus", "Regulation of integrin activation", "Regulation of integrin mediated signaling pathway", "Regulation of interleukin 1 mediated signaling pathway", "Regulation of interleukin 6 mediated signaling pathway", "Regulation of intestinal absorption", "Regulation of intracellular estrogen receptor signaling pathway", "Regulation of intracellular lipid transport", "Regulation of intracellular protein transport", "Regulation of intracellular signal transduction", "Regulation of intracellular steroid hormone receptor signaling pathway", "Regulation of intracellular transport", "Regulation of intrinsic apoptotic signaling pathway", "Regulation of intrinsic apoptotic signaling pathway by p53 class mediator", "Regulation of intrinsic apoptotic signaling pathway in response to dna damage", "Regulation of intrinsic apoptotic signaling pathway in response to dna damage by p53 class mediator", "Regulation of intrinsic apoptotic signaling pathway in response to osmotic stress", "Regulation of inward rectifier potassium channel activity", "Regulation of ion transmembrane transport", "Regulation of ion transport", "Regulation of ire1 mediated unfolded protein response", "Regulation of isomerase activity", "Regulation of isotype switching", "Regulation of jnk cascade", "Regulation of jun kinase activity", "Regulation of keratinocyte differentiation", "Regulation of keratinocyte migration", "Regulation of keratinocyte proliferation", "Regulation of kidney development", "Regulation of l glutamate import across plasma membrane", "Regulation of lamellipodium assembly", "Regulation of lamellipodium morphogenesis", "Regulation of lamellipodium organization", "Regulation of leukocyte adhesion to vascular endothelial cell", "Regulation of leukocyte apoptotic process", "Regulation of leukocyte chemotaxis", "Regulation of leukocyte degranulation", "Regulation of leukocyte differentiation", "Regulation of leukocyte mediated cytotoxicity", "Regulation of leukocyte mediated immunity", "Regulation of leukocyte migration", "Regulation of leukocyte proliferation", "Regulation of ligase activity", "Regulation of lipase activity", "Regulation of lipid biosynthetic process", "Regulation of lipid catabolic process", "Regulation of lipid kinase activity", "Regulation of lipid localization", "Regulation of lipid metabolic process", "Regulation of lipid storage", "Regulation of lipid transport", "Regulation of lipophagy", "Regulation of lipopolysaccharide mediated signaling pathway", "Regulation of lipoprotein lipase activity", "Regulation of lipoprotein metabolic process", "Regulation of lipoprotein particle clearance", "Regulation of locomotion involved in locomotory behavior", "Regulation of long chain fatty acid import across plasma membrane", "Regulation of long chain fatty acid import into cell", "Regulation of long term neuronal synaptic plasticity", "Regulation of long term synaptic depression", "Regulation of long term synaptic potentiation", "Regulation of low density lipoprotein particle clearance", "Regulation of lyase activity", "Regulation of lymphangiogenesis", "Regulation of lymphocyte activation", "Regulation of lymphocyte apoptotic process", "Regulation of lymphocyte chemotaxis", "Regulation of lymphocyte differentiation", "Regulation of lymphocyte mediated immunity", "Regulation of lymphocyte migration", "Regulation of lymphoid progenitor cell differentiation", "Regulation of lysosomal lumen ph", "Regulation of lysosomal protein catabolic process", "Regulation of lysosome organization", "Regulation of macroautophagy", "Regulation of macrophage activation", "Regulation of macrophage apoptotic process", "Regulation of macrophage chemotaxis", "Regulation of macrophage derived foam cell differentiation", "Regulation of macrophage differentiation", "Regulation of macrophage migration", "Regulation of macrophage proliferation", "Regulation of maintenance of sister chromatid cohesion", "Regulation of male gonad development", "Regulation of mammary gland epithelial cell proliferation", "Regulation of map kinase activity", "Regulation of mast cell activation", "Regulation of mast cell activation involved in immune response", "Regulation of mda 5 signaling pathway", "Regulation of megakaryocyte differentiation", "Regulation of meiotic cell cycle", "Regulation of meiotic nuclear division", "Regulation of membrane depolarization", "Regulation of membrane depolarization during action potential", "Regulation of membrane depolarization during cardiac muscle cell action potential", "Regulation of membrane lipid distribution", "Regulation of membrane permeability", "Regulation of membrane potential", "Regulation of membrane protein ectodomain proteolysis", "Regulation of membrane repolarization", "Regulation of membrane repolarization during action potential", "Regulation of membrane repolarization during cardiac muscle cell action potential", "Regulation of membrane tubulation", "Regulation of mesenchymal cell proliferation", "Regulation of mesenchymal stem cell differentiation", "Regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis", "Regulation of mesoderm development", "Regulation of metal ion transport", "Regulation of metalloendopeptidase activity", "Regulation of metallopeptidase activity", "Regulation of metanephros development", "Regulation of metaphase plate congression", "Regulation of microglial cell activation", "Regulation of microtubule based movement", "Regulation of microtubule based process", "Regulation of microtubule binding", "Regulation of microtubule cytoskeleton organization", "Regulation of microtubule depolymerization", "Regulation of microtubule nucleation", "Regulation of microtubule polymerization", "Regulation of microtubule polymerization or depolymerization", "Regulation of microvillus assembly", "Regulation of microvillus length", "Regulation of microvillus organization", "Regulation of mirna catabolic process", "Regulation of mirna metabolic process", "Regulation of mirna transcription", "Regulation of mitochondrial atp synthesis coupled electron transport", "Regulation of mitochondrial dna replication", "Regulation of mitochondrial electron transport nadh to ubiquinone", "Regulation of mitochondrial fission", "Regulation of mitochondrial fusion", "Regulation of mitochondrial gene expression", "Regulation of mitochondrial membrane permeability", "Regulation of mitochondrial membrane permeability involved in apoptotic process", "Regulation of mitochondrial membrane potential", "Regulation of mitochondrial mrna stability", "Regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway", "Regulation of mitochondrial rna catabolic process", "Regulation of mitochondrion organization", "Regulation of mitophagy", "Regulation of mitotic cell cycle", "Regulation of mitotic cell cycle phase transition", "Regulation of mitotic cell cycle spindle assembly checkpoint", "Regulation of mitotic centrosome separation", "Regulation of mitotic cytokinesis", "Regulation of mitotic nuclear division", "Regulation of mitotic recombination", "Regulation of mitotic sister chromatid segregation", "Regulation of mitotic spindle assembly", "Regulation of modification of postsynaptic structure", "Regulation of modification of synaptic structure", "Regulation of monocyte chemotaxis", "Regulation of monocyte differentiation", "Regulation of monocyte extravasation", "Regulation of mononuclear cell migration", "Regulation of monooxygenase activity", "Regulation of morphogenesis of a branching structure", "Regulation of morphogenesis of an epithelium", "Regulation of motor neuron apoptotic process", "Regulation of mrna 3 end processing", "Regulation of mrna binding", "Regulation of mrna catabolic process", "Regulation of mrna export from nucleus", "Regulation of mrna metabolic process", "Regulation of mrna polyadenylation", "Regulation of mrna processing", "Regulation of mrna splicing via spliceosome", "Regulation of mucus secretion", "Regulation of multicellular organism growth", "Regulation of multicellular organismal development", "Regulation of muscle adaptation", "Regulation of muscle cell differentiation", "Regulation of muscle contraction", "Regulation of muscle hypertrophy", "Regulation of muscle organ development", "Regulation of muscle system process", "Regulation of myelination", "Regulation of myeloid cell apoptotic process", "Regulation of myeloid cell differentiation", "Regulation of myeloid leukocyte differentiation", "Regulation of myeloid leukocyte mediated immunity", "Regulation of myoblast differentiation", "Regulation of myoblast fusion", "Regulation of myosin light chain phosphatase activity", "Regulation of myotube differentiation", "Regulation of nad p h oxidase activity", "Regulation of nadp metabolic process", "Regulation of natural killer cell activation", "Regulation of natural killer cell mediated immunity", "Regulation of necrotic cell death", "Regulation of nervous system development", "Regulation of nervous system process", "Regulation of neural precursor cell proliferation", "Regulation of neuroblast proliferation", "Regulation of neurogenesis", "Regulation of neuromuscular junction development", "Regulation of neuron differentiation", "Regulation of neuron migration", "Regulation of neuron projection arborization", "Regulation of neuron projection development", "Regulation of neuron projection regeneration", "Regulation of neuronal action potential", "Regulation of neuronal synaptic plasticity", "Regulation of neurotransmitter levels", "Regulation of neurotransmitter receptor activity", "Regulation of neurotransmitter transport", "Regulation of neurotransmitter uptake", "Regulation of neurotrophin trk receptor signaling pathway", "Regulation of neutrophil chemotaxis", "Regulation of neutrophil migration", "Regulation of nik nf kappab signaling", "Regulation of nitric oxide metabolic process", "Regulation of nitric oxide synthase activity", "Regulation of nk t cell activation", "Regulation of nk t cell differentiation", "Regulation of nmda receptor activity", "Regulation of non motile cilium assembly", "Regulation of notch signaling pathway", "Regulation of nuclear cell cycle dna replication", "Regulation of nuclear division", "Regulation of nuclear transcribed mrna catabolic process deadenylation dependent decay", "Regulation of nuclear transcribed mrna catabolic process nonsense mediated decay", "Regulation of nuclear transcribed mrna poly a tail shortening", "Regulation of nuclease activity", "Regulation of nucleobase containing compound transport", "Regulation of nucleocytoplasmic transport", "Regulation of nucleotide binding oligomerization domain containing 2 signaling pathway", "Regulation of nucleotide binding oligomerization domain containing signaling pathway", "Regulation of nucleotide biosynthetic process", "Regulation of nucleotide metabolic process", "Regulation of oligodendrocyte differentiation", "Regulation of oocyte maturation", "Regulation of organ growth", "Regulation of organelle assembly", "Regulation of organelle organization", "Regulation of organelle transport along microtubule", "Regulation of organic acid transport", "Regulation of ossification", "Regulation of osteoblast differentiation", "Regulation of osteoblast proliferation", "Regulation of osteoclast differentiation", "Regulation of oxidative phosphorylation", "Regulation of oxidative stress induced cell death", "Regulation of oxidative stress induced intrinsic apoptotic signaling pathway", "Regulation of oxidoreductase activity", "Regulation of p38mapk cascade", "Regulation of pancreatic juice secretion", "Regulation of pattern recognition receptor signaling pathway", "Regulation of penile erection", "Regulation of peptidase activity", "Regulation of peptide transport", "Regulation of peptidyl lysine acetylation", "Regulation of peptidyl serine phosphorylation", "Regulation of peptidyl serine phosphorylation of stat protein", "Regulation of peptidyl threonine phosphorylation", "Regulation of peptidyl tyrosine phosphorylation", "Regulation of perk mediated unfolded protein response", "Regulation of peroxisome proliferator activated receptor signaling pathway", "Regulation of ph", "Regulation of phagocytosis", "Regulation of phenotypic switching", "Regulation of phosphatase activity", "Regulation of phosphatidylcholine biosynthetic process", "Regulation of phosphatidylcholine metabolic process", "Regulation of phosphatidylinositol 3 kinase activity", "Regulation of phosphatidylinositol 3 kinase signaling", "Regulation of phospholipase a2 activity", "Regulation of phospholipase activity", "Regulation of phospholipase c activity", "Regulation of phospholipid biosynthetic process", "Regulation of phospholipid catabolic process", "Regulation of phospholipid metabolic process", "Regulation of phosphoprotein phosphatase activity", "Regulation of phosphorus metabolic process", "Regulation of pigmentation", "Regulation of pinocytosis", "Regulation of plasma lipoprotein particle levels", "Regulation of plasma membrane organization", "Regulation of plasminogen activation", "Regulation of platelet activation", "Regulation of platelet aggregation", "Regulation of platelet derived growth factor receptor signaling pathway", "Regulation of podosome assembly", "Regulation of polysaccharide metabolic process", "Regulation of post translational protein modification", "Regulation of postsynapse organization", "Regulation of postsynaptic membrane neurotransmitter receptor levels", "Regulation of postsynaptic membrane potential", "Regulation of postsynaptic neurotransmitter receptor internalization", "Regulation of potassium ion import", "Regulation of potassium ion transmembrane transporter activity", "Regulation of potassium ion transport", "Regulation of presynapse organization", "Regulation of presynaptic cytosolic calcium ion concentration", "Regulation of pro b cell differentiation", "Regulation of production of molecular mediator of immune response", "Regulation of production of small rna involved in gene silencing by rna", "Regulation of programmed necrotic cell death", "Regulation of prostaglandin secretion", "Regulation of proteasomal protein catabolic process", "Regulation of proteasomal ubiquitin dependent protein catabolic process", "Regulation of protein acetylation", "Regulation of protein adp ribosylation", "Regulation of protein autophosphorylation", "Regulation of protein autoubiquitination", "Regulation of protein binding", "Regulation of protein catabolic process", "Regulation of protein catabolic process in the vacuole", "Regulation of protein complex stability", "Regulation of protein containing complex assembly", "Regulation of protein containing complex disassembly", "Regulation of protein deacetylation", "Regulation of protein dephosphorylation", "Regulation of protein depolymerization", "Regulation of protein deubiquitination", "Regulation of protein exit from endoplasmic reticulum", "Regulation of protein export from nucleus", "Regulation of protein folding", "Regulation of protein glycosylation", "Regulation of protein import", "Regulation of protein k63 linked ubiquitination", "Regulation of protein kinase a signaling", "Regulation of protein kinase activity", "Regulation of protein kinase c signaling", "Regulation of protein lipidation", "Regulation of protein localization", "Regulation of protein localization to cell cortex", "Regulation of protein localization to cell periphery", "Regulation of protein localization to cell surface", "Regulation of protein localization to centrosome", "Regulation of protein localization to chromatin", "Regulation of protein localization to chromosome telomeric region", "Regulation of protein localization to cilium", "Regulation of protein localization to endosome", "Regulation of protein localization to membrane", "Regulation of protein localization to nucleolus", "Regulation of protein localization to nucleus", "Regulation of protein localization to plasma membrane", "Regulation of protein maturation", "Regulation of protein modification by small protein conjugation or removal", "Regulation of protein modification process", "Regulation of protein monoubiquitination", "Regulation of protein neddylation", "Regulation of protein phosphorylation", "Regulation of protein polymerization", "Regulation of protein polyubiquitination", "Regulation of protein secretion", "Regulation of protein serine threonine kinase activity", "Regulation of protein stability", "Regulation of protein sumoylation", "Regulation of protein targeting", "Regulation of protein targeting to membrane", "Regulation of protein tyrosine kinase activity", "Regulation of protein tyrosine phosphatase activity", "Regulation of proteolysis", "Regulation of proton transport", "Regulation of rac protein signal transduction", "Regulation of ras protein signal transduction", "Regulation of reactive oxygen species biosynthetic process", "Regulation of reactive oxygen species metabolic process", "Regulation of receptor binding", "Regulation of receptor catabolic process", "Regulation of receptor clustering", "Regulation of receptor internalization", "Regulation of receptor localization to synapse", "Regulation of receptor mediated endocytosis", "Regulation of receptor mediated endocytosis involved in cholesterol transport", "Regulation of receptor recycling", "Regulation of receptor signaling pathway via stat", "Regulation of regulated secretory pathway", "Regulation of relaxation of muscle", "Regulation of release of cytochrome c from mitochondria", "Regulation of release of sequestered calcium ion into cytosol", "Regulation of removal of superoxide radicals", "Regulation of renal system process", "Regulation of reproductive process", "Regulation of respiratory burst", "Regulation of respiratory gaseous exchange", "Regulation of respiratory gaseous exchange by nervous system process", "Regulation of respiratory system process", "Regulation of response to biotic stimulus", "Regulation of response to cytokine stimulus", "Regulation of response to dna damage stimulus", "Regulation of response to endoplasmic reticulum stress", "Regulation of response to external stimulus", "Regulation of response to extracellular stimulus", "Regulation of response to food", "Regulation of response to interferon gamma", "Regulation of response to osmotic stress", "Regulation of response to oxidative stress", "Regulation of response to reactive oxygen species", "Regulation of response to stress", "Regulation of response to tumor cell", "Regulation of response to wounding", "Regulation of retinal ganglion cell axon guidance", "Regulation of retinoic acid receptor signaling pathway", "Regulation of retrograde protein transport er to cytosol", "Regulation of retrograde transport endosome to golgi", "Regulation of rho dependent protein serine threonine kinase activity", "Regulation of rho protein signal transduction", "Regulation of rhodopsin mediated signaling pathway", "Regulation of ribonuclease activity", "Regulation of ribosome biogenesis", "Regulation of rig i signaling pathway", "Regulation of rna binding", "Regulation of rna export from nucleus", "Regulation of rna polymerase ii regulatory region sequence specific dna binding", "Regulation of rna polymerase ii transcription preinitiation complex assembly", "Regulation of rna splicing", "Regulation of rrna processing", "Regulation of ruffle assembly", "Regulation of ryanodine sensitive calcium release channel activity", "Regulation of sarcomere organization", "Regulation of secondary heart field cardioblast proliferation", "Regulation of secondary metabolic process", "Regulation of secretion", "Regulation of sensory perception", "Regulation of sequestering of triglyceride", "Regulation of sequestering of zinc ion", "Regulation of short term neuronal synaptic plasticity", "Regulation of signal transduction by p53 class mediator", "Regulation of signaling receptor activity", "Regulation of sister chromatid cohesion", "Regulation of skeletal muscle adaptation", "Regulation of skeletal muscle cell differentiation", "Regulation of skeletal muscle contraction", "Regulation of skeletal muscle contraction by calcium ion signaling", "Regulation of skeletal muscle fiber development", "Regulation of skeletal muscle tissue development", "Regulation of smad protein complex assembly", "Regulation of smad protein signal transduction", "Regulation of small gtpase mediated signal transduction", "Regulation of small molecule metabolic process", "Regulation of smooth muscle cell chemotaxis", "Regulation of smooth muscle cell differentiation", "Regulation of smooth muscle contraction", "Regulation of smoothened signaling pathway", "Regulation of smoothened signaling pathway involved in dorsal ventral neural tube patterning", "Regulation of snrna transcription by rna polymerase ii", "Regulation of sodium ion transmembrane transport", "Regulation of sodium ion transport", "Regulation of sodium proton antiporter activity", "Regulation of somitogenesis", "Regulation of spindle assembly", "Regulation of spindle organization", "Regulation of spontaneous synaptic transmission", "Regulation of sprouting angiogenesis", "Regulation of srebp signaling pathway", "Regulation of stem cell differentiation", "Regulation of stem cell population maintenance", "Regulation of stem cell proliferation", "Regulation of steroid biosynthetic process", "Regulation of steroid hormone biosynthetic process", "Regulation of steroid metabolic process", "Regulation of sterol transport", "Regulation of stress activated protein kinase signaling cascade", "Regulation of stress granule assembly", "Regulation of striated muscle cell differentiation", "Regulation of striated muscle contraction", "Regulation of substrate adhesion dependent cell spreading", "Regulation of sulfur metabolic process", "Regulation of superoxide anion generation", "Regulation of superoxide dismutase activity", "Regulation of superoxide metabolic process", "Regulation of supramolecular fiber organization", "Regulation of synapse assembly", "Regulation of synapse maturation", "Regulation of synapse structural plasticity", "Regulation of synapse structure or activity", "Regulation of synaptic plasticity", "Regulation of synaptic transmission dopaminergic", "Regulation of synaptic transmission gabaergic", "Regulation of synaptic transmission glutamatergic", "Regulation of synaptic vesicle endocytosis", "Regulation of synaptic vesicle exocytosis", "Regulation of synaptic vesicle priming", "Regulation of synaptic vesicle recycling", "Regulation of syncytium formation by plasma membrane fusion", "Regulation of system process", "Regulation of systemic arterial blood pressure", "Regulation of systemic arterial blood pressure by endothelin", "Regulation of systemic arterial blood pressure by hormone", "Regulation of systemic arterial blood pressure by norepinephrine epinephrine", "Regulation of systemic arterial blood pressure by renin angiotensin", "Regulation of systemic arterial blood pressure mediated by a chemical signal", "Regulation of t cell activation", "Regulation of t cell activation via t cell receptor contact with antigen bound to mhc molecule on antigen presenting cell", "Regulation of t cell apoptotic process", "Regulation of t cell chemotaxis", "Regulation of t cell differentiation", "Regulation of t cell differentiation in thymus", "Regulation of t cell mediated cytotoxicity", "Regulation of t cell mediated immune response to tumor cell", "Regulation of t cell mediated immunity", "Regulation of t cell migration", "Regulation of t cell proliferation", "Regulation of t cell receptor signaling pathway", "Regulation of t circle formation", "Regulation of t helper 1 cell differentiation", "Regulation of t helper 1 type immune response", "Regulation of t helper 2 cell differentiation", "Regulation of t helper cell differentiation", "Regulation of tau protein kinase activity", "Regulation of telomerase activity", "Regulation of telomere capping", "Regulation of telomere maintenance", "Regulation of telomere maintenance via telomere lengthening", "Regulation of tetrapyrrole metabolic process", "Regulation of the force of heart contraction", "Regulation of thymocyte apoptotic process", "Regulation of tissue remodeling", "Regulation of tolerance induction", "Regulation of toll like receptor 3 signaling pathway", "Regulation of toll like receptor 4 signaling pathway", "Regulation of toll like receptor 7 signaling pathway", "Regulation of toll like receptor 9 signaling pathway", "Regulation of toll like receptor signaling pathway", "Regulation of tor signaling", "Regulation of torc2 signaling", "Regulation of trail activated apoptotic signaling pathway", "Regulation of trans synaptic signaling", "Regulation of transcription by glucose", "Regulation of transcription by rna polymerase i", "Regulation of transcription by rna polymerase iii", "Regulation of transcription elongation from rna polymerase ii promoter", "Regulation of transcription from rna polymerase ii promoter in response to hypoxia", "Regulation of transcription from rna polymerase ii promoter in response to oxidative stress", "Regulation of transcription involved in g1 s transition of mitotic cell cycle", "Regulation of transcription of nucleolar large rrna by rna polymerase i", "Regulation of transcription regulatory region dna binding", "Regulation of transferase activity", "Regulation of transforming growth factor beta activation", "Regulation of transforming growth factor beta1 production", "Regulation of translation at synapse modulating synaptic transmission", "Regulation of translation in response to endoplasmic reticulum stress", "Regulation of translation in response to stress", "Regulation of translation initiation in response to endoplasmic reticulum stress", "Regulation of translational elongation", "Regulation of translational fidelity", "Regulation of translational initiation", "Regulation of translational initiation by eif2 alpha phosphorylation", "Regulation of translational initiation in response to stress", "Regulation of translational termination", "Regulation of transmembrane receptor protein serine threonine kinase signaling pathway", "Regulation of transmembrane transport", "Regulation of transmission of nerve impulse", "Regulation of transport", "Regulation of transporter activity", "Regulation of transposition", "Regulation of triglyceride biosynthetic process", "Regulation of triglyceride catabolic process", "Regulation of triglyceride metabolic process", "Regulation of tube size", "Regulation of tumor necrosis factor mediated signaling pathway", "Regulation of type b pancreatic cell development", "Regulation of type i interferon mediated signaling pathway", "Regulation of ubiquitin dependent protein catabolic process", "Regulation of ubiquitin protein ligase activity", "Regulation of ubiquitin protein transferase activity", "Regulation of ubiquitin specific protease activity", "Regulation of unsaturated fatty acid biosynthetic process", "Regulation of urine volume", "Regulation of vacuole organization", "Regulation of vascular associated smooth muscle cell differentiation", "Regulation of vascular associated smooth muscle contraction", "Regulation of vascular endothelial growth factor receptor signaling pathway", "Regulation of vascular permeability", "Regulation of vasculature development", "Regulation of vasculogenesis", "Regulation of vasoconstriction", "Regulation of ventricular cardiac muscle cell action potential", "Regulation of very low density lipoprotein particle clearance", "Regulation of vesicle fusion", "Regulation of vesicle mediated transport", "Regulation of vesicle size", "Regulation of viral entry into host cell", "Regulation of viral genome replication", "Regulation of viral induced cytoplasmic pattern recognition receptor signaling pathway", "Regulation of viral process", "Regulation of viral transcription", "Regulation of vitamin d biosynthetic process", "Regulation of vitamin d receptor signaling pathway", "Regulation of vitamin metabolic process", "Regulation of voltage gated calcium channel activity", "Regulation of water loss via skin", "Regulation of wnt signaling pathway", "Regulation of wound healing", "Regulation of wound healing spreading of epidermal cells", "Relaxation of cardiac muscle", "Relaxation of muscle", "Release of cytochrome c from mitochondria", "Release of sequestered calcium ion into cytosol by endoplasmic reticulum", "Renal absorption", "Renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure", "Renal filtration", "Renal sodium excretion", "Renal sodium ion absorption", "Renal sodium ion transport", "Renal system process", "Renal system process involved in regulation of systemic arterial blood pressure", "Renal tubular secretion", "Renal tubule development", "Renal vesicle development", "Renal vesicle formation", "Renal water homeostasis", "Replacement ossification", "Replication born double strand break repair via sister chromatid exchange", "Replication fork processing", "Replicative senescence", "Reproduction", "Reproductive behavior", "Reproductive system development", "Rescue of stalled ribosome", "Resolution of meiotic recombination intermediates", "Respiratory burst", "Respiratory burst involved in defense response", "Respiratory burst involved in inflammatory response", "Respiratory chain complex iii assembly", "Respiratory chain complex iv assembly", "Respiratory electron transport chain", "Respiratory gaseous exchange by respiratory system", "Respiratory system development", "Respiratory system process", "Response to abiotic stimulus", "Response to acetylcholine", "Response to acid chemical", "Response to acidic ph", "Response to actinomycin d", "Response to activity", "Response to alcohol", "Response to aldosterone", "Response to alkaloid", "Response to amine", "Response to amino acid starvation", "Response to ammonium ion", "Response to amphetamine", "Response to amyloid beta", "Response to angiotensin", "Response to antibiotic", "Response to arsenic containing substance", "Response to arsenite ion", "Response to atp", "Response to auditory stimulus", "Response to axon injury", "Response to bacterium", "Response to bmp", "Response to cadmium ion", "Response to caffeine", "Response to calcium ion", "Response to camp", "Response to carbohydrate", "Response to catecholamine", "Response to cell cycle checkpoint signaling", "Response to cgmp", "Response to chemokine", "Response to cisplatin", "Response to cobalt ion", "Response to cocaine", "Response to cold", "Response to copper ion", "Response to corticosteroid", "Response to corticosterone", "Response to cortisol", "Response to cytokine", "Response to dexamethasone", "Response to dietary excess", "Response to dopamine", "Response to dsrna", "Response to electrical stimulus", "Response to endogenous stimulus", "Response to endoplasmic reticulum stress", "Response to epidermal growth factor", "Response to epinephrine", "Response to estradiol", "Response to estrogen", "Response to ethanol", "Response to ether", "Response to extracellular stimulus", "Response to fatty acid", "Response to fibroblast growth factor", "Response to fluid shear stress", "Response to folic acid", "Response to follicle stimulating hormone", "Response to food", "Response to forskolin", "Response to fungus", "Response to gamma radiation", "Response to glucagon", "Response to glycoside", "Response to gonadotropin", "Response to granulocyte macrophage colony stimulating factor", "Response to growth factor", "Response to growth hormone", "Response to heat", "Response to heparin", "Response to hepatocyte growth factor", "Response to histamine", "Response to hormone", "Response to human chorionic gonadotropin", "Response to hydrogen peroxide", "Response to hydroperoxide", "Response to hydrostatic pressure", "Response to hydroxyurea", "Response to hyperoxia", "Response to immobilization stress", "Response to increased oxygen levels", "Response to indole 3 methanol", "Response to inorganic substance", "Response to insecticide", "Response to insulin", "Response to interferon alpha", "Response to interferon beta", "Response to interferon gamma", "Response to interleukin 1", "Response to interleukin 12", "Response to interleukin 3", "Response to interleukin 4", "Response to interleukin 6", "Response to interleukin 7", "Response to ionizing radiation", "Response to iron ii ion", "Response to iron ion", "Response to ischemia", "Response to isoquinoline alkaloid", "Response to ketone", "Response to l ascorbic acid", "Response to l glutamate", "Response to l phenylalanine derivative", "Response to lead ion", "Response to lectin", "Response to leptin", "Response to leucine", "Response to leukemia inhibitory factor", "Response to light intensity", "Response to light stimulus", "Response to lipid", "Response to lipoteichoic acid", "Response to lithium ion", "Response to magnesium ion", "Response to manganese ion", "Response to mechanical stimulus", "Response to mercury ion", "Response to metal ion", "Response to methylmercury", "Response to mineralocorticoid", "Response to misfolded protein", "Response to mitochondrial depolarisation", "Response to molecule of bacterial origin", "Response to monosaccharide", "Response to muramyl dipeptide", "Response to muscle activity", "Response to muscle stretch", "Response to nerve growth factor", "Response to nicotine", "Response to nitric oxide", "Response to nitrogen compound", "Response to nitrosative stress", "Response to nutrient", "Response to oleic acid", "Response to organic cyclic compound", "Response to osmotic stress", "Response to oxidative stress", "Response to oxygen containing compound", "Response to oxygen glucose deprivation", "Response to oxygen levels", "Response to oxygen radical", "Response to pain", "Response to parathyroid hormone", "Response to peptide", "Response to peptide hormone", "Response to peptidoglycan", "Response to ph", "Response to phorbol 13 acetate 12 myristate", "Response to platelet derived growth factor", "Response to potassium ion", "Response to progesterone", "Response to prostaglandin", "Response to prostaglandin e", "Response to purine containing compound", "Response to radiation", "Response to reactive oxygen species", "Response to redox state", "Response to retinoic acid", "Response to salt", "Response to salt stress", "Response to selenium ion", "Response to sodium arsenite", "Response to sorbitol", "Response to starvation", "Response to staurosporine", "Response to steroid hormone", "Response to sterol depletion", "Response to temperature stimulus", "Response to testosterone", "Response to thyroglobulin triiodothyronine", "Response to thyroid hormone", "Response to thyroxine", "Response to topologically incorrect protein", "Response to toxic substance", "Response to transforming growth factor beta", "Response to tumor cell", "Response to tumor necrosis factor", "Response to type i interferon", "Response to uv", "Response to uv a", "Response to uv b", "Response to uv c", "Response to virus", "Response to vitamin", "Response to vitamin a", "Response to vitamin d", "Response to vitamin k", "Response to water", "Response to wounding", "Response to x ray", "Response to xenobiotic stimulus", "Response to zinc ion", "Reticulophagy", "Retina development in camera type eye", "Retina homeostasis", "Retina layer formation", "Retina morphogenesis in camera type eye", "Retina vasculature development in camera type eye", "Retina vasculature morphogenesis in camera type eye", "Retinal cell apoptotic process", "Retinal cone cell differentiation", "Retinal ganglion cell axon guidance", "Retinal metabolic process", "Retinal pigment epithelium development", "Retinal rod cell development", "Retinal rod cell differentiation", "Retinoic acid metabolic process", "Retinoic acid receptor signaling pathway", "Retinol metabolic process", "Retrograde axonal transport", "Retrograde trans synaptic signaling", "Retrograde trans synaptic signaling by lipid", "Retrograde transport endosome to golgi", "Retrograde transport vesicle recycling within golgi", "Retrograde vesicle mediated transport golgi to endoplasmic reticulum", "Reverse cholesterol transport", "Reversible differentiation", "Rho protein signal transduction", "Rhodopsin mediated signaling pathway", "Rhythmic behavior", "Rhythmic process", "Riboflavin metabolic process", "Ribonucleoprotein complex biogenesis", "Ribonucleoprotein complex disassembly", "Ribonucleoprotein complex localization", "Ribonucleoprotein complex subunit organization", "Ribonucleoside catabolic process", "Ribonucleoside diphosphate biosynthetic process", "Ribonucleoside diphosphate catabolic process", "Ribonucleoside diphosphate metabolic process", "Ribonucleoside metabolic process", "Ribonucleoside monophosphate biosynthetic process", "Ribonucleoside monophosphate catabolic process", "Ribonucleoside monophosphate metabolic process", "Ribonucleoside triphosphate biosynthetic process", "Ribonucleoside triphosphate metabolic process", "Ribonucleotide catabolic process", "Ribose phosphate biosynthetic process", "Ribose phosphate metabolic process", "Ribosomal large subunit assembly", "Ribosomal large subunit biogenesis", "Ribosomal large subunit export from nucleus", "Ribosomal small subunit assembly", "Ribosomal small subunit biogenesis", "Ribosomal small subunit export from nucleus", "Ribosomal subunit export from nucleus", "Ribosome assembly", "Ribosome associated ubiquitin dependent protein catabolic process", "Ribosome biogenesis", "Ribosome disassembly", "Rig i signaling pathway", "Righting reflex", "Rna 3 end processing", "Rna 5 end processing", "Rna capping", "Rna catabolic process", "Rna decapping", "Rna dependent dna biosynthetic process", "Rna destabilization", "Rna export from nucleus", "Rna import into mitochondrion", "Rna interference", "Rna localization", "Rna mediated gene silencing by inhibition of translation", "Rna methylation", "Rna modification", "Rna phosphodiester bond hydrolysis", "Rna phosphodiester bond hydrolysis endonucleolytic", "Rna phosphodiester bond hydrolysis exonucleolytic", "Rna polyadenylation", "Rna polymerase i preinitiation complex assembly", "Rna polymerase ii preinitiation complex assembly", "Rna processing", "Rna secondary structure unwinding", "Rna splicing", "Rna splicing via endonucleolytic cleavage and ligation", "Rna splicing via transesterification reactions", "Rna stabilization", "Rna surveillance", "Roof of mouth development", "Roundabout signaling pathway", "Rrna 3 end processing", "Rrna 5 end processing", "Rrna base methylation", "Rrna catabolic process", "Rrna metabolic process", "Rrna methylation", "Rrna modification", "Rrna pseudouridine synthesis", "Rrna transcription", "Rrna transport", "Ruffle assembly", "Ruffle organization", "S adenosylmethionine cycle", "S adenosylmethionine metabolic process", "Salivary gland development", "Sarcomere organization", "Sarcoplasmic reticulum calcium ion transport", "Satellite cell activation involved in skeletal muscle regeneration", "Scarna localization to cajal body", "Scf dependent proteasomal ubiquitin dependent protein catabolic process", "Schwann cell development", "Schwann cell differentiation", "Schwann cell proliferation", "Second messenger mediated signaling", "Secondary alcohol metabolic process", "Secondary metabolic process", "Secondary metabolite biosynthetic process", "Secretion", "Secretion by tissue", "Secretion of lysosomal enzymes", "Secretory granule localization", "Secretory granule organization", "Segmentation", "Selective autophagy", "Self proteolysis", "Semaphorin plexin signaling pathway", "Semaphorin plexin signaling pathway involved in neuron projection guidance", "Semi lunar valve development", "Sensory organ development", "Sensory organ morphogenesis", "Sensory perception", "Sensory perception of light stimulus", "Sensory perception of mechanical stimulus", "Sensory perception of pain", "Sensory system development", "Septum primum development", "Sequestering of actin monomers", "Sequestering of calcium ion", "Sequestering of iron ion", "Sequestering of metal ion", "Sequestering of triglyceride", "Sequestering of zinc ion", "Serine family amino acid biosynthetic process", "Serine family amino acid catabolic process", "Serine family amino acid metabolic process", "Serine phosphorylation of stat protein", "Serine transport", "Serotonin metabolic process", "Sertoli cell development", "Sertoli cell differentiation", "Sex determination", "Sex differentiation", "Short chain fatty acid catabolic process", "Short chain fatty acid metabolic process", "Short term memory", "Signal peptide processing", "Signal release", "Signal transduction by p53 class mediator", "Signal transduction in absence of ligand", "Signal transduction in response to dna damage", "Signal transduction involved in regulation of gene expression", "Signaling receptor ligand precursor processing", "Single fertilization", "Single strand break repair", "Single stranded viral rna replication via double stranded dna intermediate", "Sister chromatid cohesion", "Sister chromatid segregation", "Skeletal muscle acetylcholine gated channel clustering", "Skeletal muscle adaptation", "Skeletal muscle cell differentiation", "Skeletal muscle cell proliferation", "Skeletal muscle contraction", "Skeletal muscle fiber differentiation", "Skeletal muscle organ development", "Skeletal muscle satellite cell activation", "Skeletal muscle tissue regeneration", "Skeletal myofibril assembly", "Skeletal system development", "Skeletal system morphogenesis", "Skin development", "Skin epidermis development", "Skin morphogenesis", "Sleep", "Smad protein complex assembly", "Smad protein signal transduction", "Small gtpase mediated signal transduction", "Small molecule biosynthetic process", "Small molecule catabolic process", "Small molecule metabolic process", "Small nucleolar ribonucleoprotein complex assembly", "Small rna loading onto risc", "Smooth muscle adaptation", "Smooth muscle cell apoptotic process", "Smooth muscle cell chemotaxis", "Smooth muscle cell differentiation", "Smooth muscle cell migration", "Smooth muscle cell proliferation", "Smooth muscle contraction", "Smoothened signaling pathway", "Smoothened signaling pathway involved in dorsal ventral neural tube patterning", "Sno s rna metabolic process", "Sno s rna processing", "Snorna localization", "Snrna metabolic process", "Snrna modification", "Snrna processing", "Snrna transcription", "Snrna transcription by rna polymerase ii", "Snrna transport", "Sodium ion export across plasma membrane", "Sodium ion homeostasis", "Sodium ion transmembrane transport", "Sodium ion transport", "Somatic diversification of immune receptors", "Somatic diversification of immune receptors via somatic mutation", "Somatic diversification of immunoglobulins", "Somatic diversification of immunoglobulins involved in immune response", "Somatic diversification of t cell receptor genes", "Somatic stem cell population maintenance", "Somite development", "Somite rostral caudal axis specification", "Somitogenesis", "Specification of animal organ identity", "Specification of symmetry", "Sperm capacitation", "Sperm dna condensation", "Sperm egg recognition", "Sperm motility", "Spermatid differentiation", "Spermatid nucleus differentiation", "Spermatogenesis exchange of chromosomal proteins", "Spermidine metabolic process", "Sphingoid metabolic process", "Sphingolipid biosynthetic process", "Sphingolipid mediated signaling pathway", "Sphingolipid metabolic process", "Sphingolipid translocation", "Sphingomyelin biosynthetic process", "Sphingomyelin catabolic process", "Sphingomyelin metabolic process", "Sphingosine biosynthetic process", "Spinal cord development", "Spinal cord motor neuron differentiation", "Spindle assembly", "Spindle assembly involved in female meiosis", "Spindle elongation", "Spindle localization", "Spindle midzone assembly", "Spindle organization", "Spleen development", "Spliceosomal complex assembly", "Spliceosomal conformational changes to generate catalytic conformation", "Spliceosomal snrnp assembly", "Spliceosomal tri snrnp complex assembly", "Spontaneous synaptic transmission", "Sprouting angiogenesis", "Srp dependent cotranslational protein targeting to membrane", "Srp dependent cotranslational protein targeting to membrane signal sequence recognition", "Srp dependent cotranslational protein targeting to membrane translocation", "Startle response", "Stem cell differentiation", "Stem cell division", "Stem cell proliferation", "Steroid biosynthetic process", "Steroid catabolic process", "Steroid esterification", "Steroid hormone biosynthetic process", "Steroid hormone mediated signaling pathway", "Steroid metabolic process", "Sterol biosynthetic process", "Sterol homeostasis", "Sterol import", "Sterol metabolic process", "Sterol transport", "Stress activated protein kinase signaling cascade", "Stress fiber assembly", "Stress granule assembly", "Stress granule disassembly", "Stress induced premature senescence", "Stress response to metal ion", "Striated muscle adaptation", "Striated muscle cell apoptotic process", "Striated muscle cell development", "Striated muscle cell differentiation", "Striated muscle cell proliferation", "Striated muscle contraction", "Striatum development", "Subpallium development", "Substantia nigra development", "Substrate adhesion dependent cell spreading", "Substrate dependent cell migration", "Substrate dependent cell migration cell extension", "Substrate independent telencephalic tangential migration", "Subtelomeric heterochromatin assembly", "Succinate metabolic process", "Succinate transmembrane transport", "Succinyl coa metabolic process", "Suckling behavior", "Sugar mediated signaling pathway", "Sulfate transport", "Sulfur amino acid biosynthetic process", "Sulfur amino acid catabolic process", "Sulfur amino acid metabolic process", "Sulfur compound biosynthetic process", "Sulfur compound catabolic process", "Sulfur compound metabolic process", "Sulfur compound transport", "Superoxide anion generation", "Superoxide metabolic process", "Suppression of viral release by host", "Supramolecular fiber organization", "Sympathetic ganglion development", "Sympathetic nervous system development", "Synapse assembly", "Synapse maturation", "Synapse organization", "Synaptic assembly at neuromuscular junction", "Synaptic membrane adhesion", "Synaptic signaling", "Synaptic transmission dopaminergic", "Synaptic transmission gabaergic", "Synaptic transmission glutamatergic", "Synaptic vesicle budding", "Synaptic vesicle clustering", "Synaptic vesicle cytoskeletal transport", "Synaptic vesicle docking", "Synaptic vesicle endosomal processing", "Synaptic vesicle exocytosis", "Synaptic vesicle localization", "Synaptic vesicle maturation", "Synaptic vesicle membrane organization", "Synaptic vesicle priming", "Synaptic vesicle recycling", "Synaptic vesicle recycling via endosome", "Synaptic vesicle transport", "Synaptic vesicle uncoating", "Synaptonemal complex organization", "Syncytium formation", "T cell activation", "T cell activation involved in immune response", "T cell activation via t cell receptor contact with antigen bound to mhc molecule on antigen presenting cell", "T cell apoptotic process", "T cell chemotaxis", "T cell cytokine production", "T cell differentiation", "T cell differentiation in thymus", "T cell differentiation involved in immune response", "T cell extravasation", "T cell homeostasis", "T cell lineage commitment", "T cell mediated cytotoxicity", "T cell mediated immune response to tumor cell", "T cell mediated immunity", "T cell migration", "T cell proliferation", "T cell proliferation involved in immune response", "T cell receptor signaling pathway", "T cell selection", "T cell tolerance induction", "T helper 1 cell differentiation", "T helper 1 type immune response", "T helper 17 cell differentiation", "T helper 17 cell lineage commitment", "T helper 17 type immune response", "T helper 2 cell differentiation", "T helper cell lineage commitment", "T tubule organization", "Tail anchored membrane protein insertion into er membrane", "Tangential migration from the subventricular zone to the olfactory bulb", "Taxis", "Telencephalon development", "Telencephalon glial cell migration", "Telencephalon regionalization", "Telomerase holoenzyme complex assembly", "Telomerase rna localization", "Telomere capping", "Telomere maintenance", "Telomere maintenance in response to dna damage", "Telomere maintenance via recombination", "Telomere maintenance via semi conservative replication", "Telomere maintenance via telomere lengthening", "Telomere organization", "Temperature homeostasis", "Terminal button organization", "Termination of rna polymerase ii transcription", "Terpenoid biosynthetic process", "Terpenoid metabolic process", "Tertiary alcohol metabolic process", "Tetrahydrobiopterin metabolic process", "Tetrahydrofolate biosynthetic process", "Tetrahydrofolate interconversion", "Tetrahydrofolate metabolic process", "Tetrapyrrole biosynthetic process", "Tetrapyrrole catabolic process", "Tetrapyrrole metabolic process", "Thalamus development", "Thioester biosynthetic process", "Thioester metabolic process", "Thorax and anterior abdomen determination", "Threonine catabolic process", "Threonine metabolic process", "Thrombin activated receptor signaling pathway", "Thymocyte apoptotic process", "Thymus development", "Thyroid gland development", "Thyroid hormone generation", "Thyroid hormone mediated signaling pathway", "Thyroid hormone metabolic process", "Tight junction organization", "Tissue development", "Tissue migration", "Tissue morphogenesis", "Tissue regeneration", "Tissue remodeling", "Tolerance induction", "Toll like receptor 3 signaling pathway", "Toll like receptor 4 signaling pathway", "Toll like receptor 7 signaling pathway", "Toll like receptor 8 signaling pathway", "Toll like receptor 9 signaling pathway", "Toll like receptor signaling pathway", "Tongue development", "Tongue morphogenesis", "Tooth mineralization", "Tor signaling", "Torc1 signaling", "Torc2 signaling", "Toxin metabolic process", "Toxin transport", "Trabecula formation", "Trabecula morphogenesis", "Trachea development", "Trachea formation", "Trachea morphogenesis", "Trail activated apoptotic signaling pathway", "Trans synaptic signaling by lipid", "Transcription by rna polymerase i", "Transcription by rna polymerase iii", "Transcription coupled nucleotide excision repair", "Transcription dependent tethering of rna polymerase ii gene dna at nuclear periphery", "Transcription elongation from rna polymerase i promoter", "Transcription elongation from rna polymerase ii promoter", "Transcription initiation from rna polymerase i promoter", "Transcription initiation from rna polymerase ii promoter", "Transcription initiation from rna polymerase iii promoter", "Transcription preinitiation complex assembly", "Transcytosis", "Transepithelial transport", "Transferrin transport", "Transforming growth factor beta activation", "Transforming growth factor beta production", "Transforming growth factor beta receptor signaling pathway", "Transforming growth factor beta1 production", "Transition between fast and slow fiber", "Transition metal ion homeostasis", "Transition metal ion transport", "Translational elongation", "Translational initiation", "Translational readthrough", "Translational termination", "Translesion synthesis", "Translocation of molecules into host", "Transmembrane receptor protein serine threonine kinase signaling pathway", "Transmembrane receptor protein tyrosine kinase signaling pathway", "Transmembrane transport", "Transmission of nerve impulse", "Transport along microtubule", "Transport of virus", "Transposition", "Transposition rna mediated", "Tricarboxylic acid cycle", "Tricarboxylic acid metabolic process", "Triglyceride biosynthetic process", "Triglyceride catabolic process", "Triglyceride metabolic process", "Tripartite regional subdivision", "Tripeptide transport", "Trivalent inorganic anion homeostasis", "Trna 3 end processing", "Trna 5 end processing", "Trna 5 leader removal", "Trna aminoacylation for mitochondrial protein translation", "Trna catabolic process", "Trna metabolic process", "Trna methylation", "Trna modification", "Trna processing", "Trna pseudouridine synthesis", "Trna threonylcarbamoyladenosine metabolic process", "Trna transcription", "Trna transport", "Trna wobble base modification", "Trna wobble uridine modification", "Trophectodermal cell differentiation", "Trophoblast cell migration", "Trophoblast giant cell differentiation", "Tryptophan transport", "Tube development", "Tube formation", "Tube morphogenesis", "Tubulin complex assembly", "Tubulin deacetylation", "Tumor necrosis factor mediated signaling pathway", "Tumor necrosis factor superfamily cytokine production", "Type 2 immune response", "Type b pancreatic cell apoptotic process", "Type b pancreatic cell development", "Type i interferon production", "Type i pneumocyte differentiation", "Tyrosine catabolic process", "Tyrosine metabolic process", "Tyrosine phosphorylation of stat protein", "U4 snrna 3 end processing", "Ubiquinone metabolic process", "Ubiquitin dependent endocytosis", "Ubiquitin dependent erad pathway", "Ubiquitin dependent protein catabolic process via the multivesicular body sorting pathway", "Ubiquitin dependent smad protein catabolic process", "Ubiquitin independent protein catabolic process via the multivesicular body sorting pathway", "Ubiquitin recycling", "Udp glucose metabolic process", "Udp n acetylglucosamine biosynthetic process", "Udp n acetylglucosamine metabolic process", "Ump biosynthetic process", "Unsaturated fatty acid biosynthetic process", "Unsaturated fatty acid metabolic process", "Urate metabolic process", "Urea cycle", "Urea metabolic process", "Urogenital system development", "Uronic acid metabolic process", "Utp biosynthetic process", "Utp metabolic process", "Uv damage excision repair", "Uv protection", "V d j recombination", "Vacuolar acidification", "Vacuolar localization", "Vacuolar proton transporting v type atpase complex assembly", "Vacuolar transport", "Vacuole organization", "Vagina development", "Valine metabolic process", "Vascular associated smooth muscle cell apoptotic process", "Vascular associated smooth muscle cell differentiation", "Vascular associated smooth muscle cell migration", "Vascular associated smooth muscle cell proliferation", "Vascular associated smooth muscle contraction", "Vascular endothelial cell proliferation", "Vascular endothelial growth factor production", "Vascular endothelial growth factor receptor 2 signaling pathway", "Vascular endothelial growth factor receptor signaling pathway", "Vascular endothelial growth factor signaling pathway", "Vascular process in circulatory system", "Vascular transport", "Vasculature development", "Vasculogenesis", "Vasoconstriction", "Vasodilation", "Ventral spinal cord development", "Ventricular cardiac muscle cell action potential", "Ventricular cardiac muscle cell development", "Ventricular cardiac muscle cell differentiation", "Ventricular cardiac muscle cell membrane repolarization", "Ventricular cardiac muscle tissue development", "Ventricular cardiac muscle tissue morphogenesis", "Ventricular compact myocardium morphogenesis", "Ventricular septum development", "Ventricular septum morphogenesis", "Ventricular system development", "Ventricular trabecula myocardium morphogenesis", "Very long chain fatty acid catabolic process", "Very long chain fatty acid metabolic process", "Very low density lipoprotein particle assembly", "Very low density lipoprotein particle clearance", "Vesicle budding from membrane", "Vesicle cargo loading", "Vesicle cytoskeletal trafficking", "Vesicle docking", "Vesicle docking involved in exocytosis", "Vesicle fusion to plasma membrane", "Vesicle fusion with golgi apparatus", "Vesicle localization", "Vesicle mediated cholesterol transport", "Vesicle mediated transport", "Vesicle mediated transport between endosomal compartments", "Vesicle mediated transport in synapse", "Vesicle mediated transport to the plasma membrane", "Vesicle organization", "Vesicle targeting", "Vesicle targeting rough er to cis golgi", "Vesicle targeting to from or within golgi", "Vesicle tethering", "Vesicle tethering to golgi", "Vesicle transport along microtubule", "Vesicle uncoating", "Viral budding", "Viral gene expression", "Viral genome replication", "Viral life cycle", "Viral process", "Viral protein processing", "Viral release from host cell", "Viral rna genome replication", "Viral transcription", "Viral translation", "Viral translational termination reinitiation", "Virion assembly", "Virion attachment to host cell", "Visual behavior", "Vitamin b6 metabolic process", "Vitamin biosynthetic process", "Vitamin catabolic process", "Vitamin d biosynthetic process", "Vitamin d metabolic process", "Vitamin d receptor signaling pathway", "Vitamin k metabolic process", "Vitamin metabolic process", "Vitamin transmembrane transport", "Vitamin transport", "Vocalization behavior", "Voluntary musculoskeletal movement", "Walking behavior", "Water homeostasis", "Water soluble vitamin biosynthetic process", "Water soluble vitamin metabolic process", "Water transport", "White fat cell differentiation", "Wnt protein secretion", "Wnt signaling pathway involved in heart development", "Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation", "Wound healing", "Wound healing involved in inflammatory response", "Wound healing spreading of epidermal cells", "Xenobiotic catabolic process", "Xenobiotic export", "Xenobiotic metabolic process", "Xenobiotic transmembrane transport", "Xenobiotic transport", "Xenobiotic transport across blood brain barrier", "Xenophagy", "Xmp metabolic process", "Zinc ion homeostasis", "Zygotic determination of anterior posterior axis embryo", "Zymogen activation", "Zymogen inhibition"], "available_proteins": ["AAAS", "AAR2", "AARS", "AARS2", "AARSD1", "AASDHPPT", "AASS", "AATF", "ABCB1", "ABCB10", "ABCB7", "ABCD3", "ABCE1", "ABCF1", "ABHD10", "ABHD12", "ABHD14B", "ABHD6", "ACAA2", "ACACA", "ACACB", "ACAD9", "ACADM", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACBD5", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT8", "ACOT9", "ACOX1", "ACOX3", "ACP1", "ACP2", "ACP6", "ACSL1", "ACSL3", "ACSL4", "ACTN1", "ACTN2", "ACTN4", "ACTR10", "ACTR1A", "ACTR2", "ACTR3", "ADA", "ADAR", "ADD1", "ADD3", "ADH5", "ADI1", "ADK", "ADNP", "ADPGK", "ADPRHL2", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGK", "AGL", "AGPAT1", "AGPS", "AHCTF1", "AHCY", "AHCYL1", "AHNAK", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AK4", "AK6", "AKAP12", "AKAP13", "AKAP8", "AKAP8L", "AKR1A1", "AKR1B1", "AKR7A2", "AKT2", "ALDH18A1", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALG1", "ALKBH5", "ALYREF", "AMOT", "ANAPC1", "ANAPC16", "ANAPC4", "ANAPC5", "ANAPC7", "ANK3", "ANKFY1", "ANKHD1", "ANKLE2", "ANKRD50", "ANLN", "ANP32A", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP1M1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "APC", "APEH", "APEX1", "API5", "APOL2", "APOOL", "APP", "APPL1", "APRT", "AQR", "ARCN1", "ARF4", "ARF5", "ARFGAP1", "ARFIP1", "ARFIP2", "ARHGAP17", "ARHGDIA", "ARHGEF1", "ARHGEF2", "ARID1A", "ARID3B", "ARIH1", "ARL1", "ARL2", "ARL3", "ARL6IP1", "ARL6IP5", "ARL8B", "ARMC1", "ARMC6", "ARMC8", "ARMCX3", "ARMT1", "ARPC1A", "ARPC2", "ARPC3", "ARPC4", "ARPC5", "ASAH1", "ASCC3", "ASF1A", "ASNA1", "ASNS", "ASPH", "ATAD1", "ATAD3A", "ATAD3B", "ATAD5", "ATE1", "ATG7", "ATIC", "ATL2", "ATP13A1", "ATP1A1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5L", "ATP5O", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1D", "ATP6V1E1", "ATP6V1H", "ATPAF1", "ATPIF1", "ATXN10", "ATXN2L", "AUP1", "AURKA", "B3GALT6", "B4GAT1", "BABAM1", "BAG2", "BAG4", "BAG5", "BAG6", "BAIAP2", "BAK1", "BANF1", "BAP18", "BASP1", "BAZ1A", "BAZ1B", "BCAP31", "BCAS2", "BCAS3", "BCCIP", "BCL2L13", "BCLAF1", "BCS1L", "BDH2", "BICD2", "BIRC6", "BLMH", "BLVRA", "BLVRB", "BMS1", "BNIP1", "BOP1", "BPNT1", "BPTF", "BRAT1", "BRD4", "BRIX1", "BSG", "BTAF1", "BTF3", "BUB1", "BUB1B", "BUB3", "BUD31", "BYSL", "BZW1", "BZW2", "C12orf43", "C12orf73", "C19orf70", "C1QBP", "CACYBP", "CAD", "CALD1", "CALM3", "CALR", "CAMK2G", "CAND1", "CANX", "CAP1", "CAPN1", "CAPNS1", "CAPRIN1", "CAPZA1", "CAPZB", "CARHSP1", "CARM1", "CARS", "CARS2", "CASK", "CASP3", "CASP6", "CASP7", "CASP8", "CAST", "CBR1", "CBX1", "CBX3", "CBX5", "CBX8", "CCAR1", "CCAR2", "CCDC124", "CCDC134", "CCDC22", "CCDC47", "CCDC6", "CCDC93", "CCDC94", "CCNB1", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2AP", "CD2BP2", "CD3EAP", "CD47", "CDC123", "CDC16", "CDC23", "CDC27", "CDC37", "CDC40", "CDC42", "CDC45", "CDC5L", "CDC73", "CDCA5", "CDIPT", "CDK1", "CDK12", "CDK2", "CDK4", "CDK5RAP3", "CDK6", "CDKN2AIP", "CDS2", "CDX2", "CEBPZ", "CELF1", "CENPV", "CEP44", "CEP55", "CERS1", "CERS2", "CETN2", "CFAP20", "CFL1", "CFL2", "CGGBP1", "CHAC2", "CHAF1B", "CHAMP1", "CHCHD3", "CHD1", "CHD4", "CHEK2", "CHERP", "CHID1", "CHKA", "CHML", "CHMP1A", "CHMP2B", "CHMP5", "CHMP6", "CHMP7", "CHORDC1", "CHRAC1", "CHST14", "CIAPIN1", "CIRBP", "CISD1", "CISD2", "CIZ1", "CKAP2", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLCC1", "CLCN3", "CLGN", "CLIC1", "CLIC4", "CLINT1", "CLN5", "CLNS1A", "CLPB", "CLPP", "CLPTM1", "CLPTM1L", "CLPX", "CLTA", "CLTC", "CLUH", "CMPK1", "CNDP2", "CNN2", "CNN3", "CNNM3", "CNNM4", "CNOT1", "CNOT7", "CNOT9", "CNP", "CNPY2", "COA3", "COASY", "COG2", "COG6", "COIL", "COLEC12", "COLGALT1", "COMT", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS7A", "COPS7B", "COPS8", "COPZ1", "COQ8A", "COQ9", "CORO1B", "CORO1C", "COTL1", "COX15", "COX2", "COX4I1", "COX5A", "COX5B", "COX6C", "COX7A2", "COX7C", "CPD", "CPNE1", "CPNE3", "CPOX", "CPPED1", "CPSF1", "CPSF2", "CPSF3", "CPSF6", "CPSF7", "CPT1A", "CPT2", "CPVL", "CRKL", "CRMP1", "CRNKL1", "CRTAP", "CRYZ", "CS", "CSDE1", "CSE1L", "CSK", "CSNK1A1", "CSNK2A2", "CSNK2B", "CSTB", "CSTF1", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTDSPL2", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTPS2", "CTR9", "CTSA", "CTSC", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4A", "CUL4B", "CUL5", "CUTA", "CWF19L1", "CXorf57", "CYB5B", "CYB5D2", "CYB5R3", "CYC1", "CYFIP1", "CYP51A1", "DAD1", "DAGLB", "DAP3", "DARS", "DARS2", "DAZAP1", "DBN1", "DBNL", "DCAF1", "DCAF13", "DCAF7", "DCAKD", "DCD", "DCP1A", "DCPS", "DCTD", "DCTN1", "DCTN2", "DCTN3", "DCTN6", "DCTPP1", "DCUN1D4", "DCUN1D5", "DCXR", "DDAH1", "DDB1", "DDI2", "DDOST", "DDRGK1", "DDT", "DDX1", "DDX10", "DDX17", "DDX18", "DDX20", "DDX21", "DDX23", "DDX27", "DDX28", "DDX39A", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX51", "DDX52", "DDX54", "DDX56", "DDX6", "DEK", "DENR", "DERL1", "DFFA", "DHCR24", "DHCR7", "DHFR", "DHPS", "DHRS7B", "DHX15", "DHX16", "DHX30", "DHX36", "DHX37", "DHX38", "DHX8", "DHX9", "DIABLO", "DIAPH1", "DIAPH3", "DICER1", "DIDO1", "DIEXF", "DIP2B", "DIS3", "DKC1", "DLAT", "DLD", "DLST", "DNAAF5", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC2", "DNAJC3", "DNAJC7", "DNAJC9", "DNM1L", "DNM2", "DNMT1", "DNPH1", "DNTTIP2", "DOCK7", "DOHH", "DOLPP1", "DPF2", "DPH2", "DPH5", "DPP3", "DPP9", "DPYSL2", "DPYSL3", "DRG1", "DRG2", "DSG2", "DSP", "DST", "DSTN", "DTL", "DTYMK", "DUSP3", "DUSP9", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNLL1", "DYNLL2", "EARS2", "EBNA1BP2", "EBP", "ECD", "ECE1", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "ECSIT", "EDC3", "EDC4", "EDF1", "EEA1", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EEFSEC", "EFL1", "EFTUD2", "EHD1", "EHD4", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2D", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAC2", "ELAVL1", "ELOB", "ELOC", "ELP1", "ELP2", "ELP3", "EMC1", "EMC2", "EMC3", "EMC4", "EMD", "EMG1", "EML4", "ENAH", "ENDOD1", "ENO1", "ENSA", "EPB41", "EPB41L2", "EPB41L3", "EPHX1", "EPHX2", "EPPK1", "EPRS", "EPS15", "EPS15L1", "ERAL1", "ERAP1", "ERCC2", "ERCC3", "ERGIC2", "ERGIC3", "ERH", "ERLIN1", "ERLIN2", "ERMP1", "ERO1A", "ERP29", "ERP44", "ESD", "ESF1", "ESYT1", "ESYT2", "ETF1", "ETFA", "ETFB", "ETFDH", "EXO1", "EXOC1", "EXOC2", "EXOC4", "EXOC5", "EXOC7", "EXOSC10", "EXOSC3", "EXOSC4", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC8", "EZR", "F11R", "FABP5", "FADS2", "FAF1", "FAF2", "FAH", "FAM162A", "FAM208A", "FAM213A", "FAM3C", "FAM49B", "FAM50A", "FAM8A1", "FAM91A1", "FAM98A", "FAM98B", "FANCI", "FAR1", "FARSA", "FARSB", "FASN", "FASTKD2", "FBL", "FBXO22", "FBXO7", "FDFT1", "FDPS", "FDX1", "FDXR", "FECH", "FEN1", "FERMT2", "FGFR1OP", "FH", "FHL1", "FHOD1", "FIP1L1", "FIS1", "FKBP10", "FKBP14", "FKBP1A", "FKBP3", "FKBP4", "FKBP5", "FKBP7", "FKBP8", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FMR1", "FN3KRP", "FNDC3A", "FNTB", "FOXC1", "FOXRED1", "FRYL", "FSCN1", "FTO", "FTSJ1", "FTSJ3", "FUBP1", "FUBP3", "FUCA1", "FUCA2", "FUNDC2", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GADD45GIP1", "GALK1", "GALNT2", "GALNT7", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GATAD2B", "GATB", "GATC", "GBA", "GBE1", "GBF1", "GCAT", "GCC2", "GCDH", "GCLM", "GCN1", "GDAP1", "GDI1", "GDI2", "GDPD1", "GEMIN4", "GEMIN5", "GET4", "GFM1", "GFPT1", "GGA1", "GGCT", "GGCX", "GGH", "GHITM", "GIGYF2", "GINS2", "GINS3", "GINS4", "GLA", "GLB1", "GLDC", "GLG1", "GLMN", "GLO1", "GLRX3", "GLRX5", "GLS", "GLUD1", "GLYR1", "GM2A", "GMDS", "GMFB", "GMPPB", "GMPS", "GNA13", "GNAI1", "GNAI2", "GNAI3", "GNL1", "GNL2", "GNL3", "GNL3L", "GNPDA1", "GNS", "GOLGA3", "GOLGB1", "GOLPH3", "GOLT1B", "GORASP2", "GOT1", "GOT2", "GPAM", "GPATCH4", "GPD2", "GPHN", "GPI", "GPKOW", "GPR107", "GPR108", "GPR89B", "GPS1", "GPT2", "GPX8", "GRB2", "GRHPR", "GRPEL1", "GRSF1", "GRWD1", "GSK3A", "GSK3B", "GSPT1", "GSR", "GSS", "GSTK1", "GSTM3", "GSTO1", "GSTZ1", "GTF2B", "GTF2E1", "GTF2F1", "GTF2F2", "GTF2I", "GTF3C1", "GTF3C2", "GTF3C3", "GTPBP1", "GTPBP10", "GTPBP3", "GTPBP4", "GUSB", "GYG1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACD3", "HADH", "HADHA", "HADHB", "HAT1", "HAUS4", "HAUS5", "HBS1L", "HCCS", "HCFC1", "HDAC2", "HDGF", "HDGFL2", "HDHD2", "HDHD5", "HDLBP", "HEATR1", "HEATR3", "HEBP1", "HECTD1", "HELLS", "HEXA", "HEXB", "HGS", "HIBADH", "HIBCH", "HINT2", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HLTF", "HM13", "HMBS", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMGCL", "HMGCS1", "HMOX1", "HMOX2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HOOK3", "HP1BP3", "HPRT1", "HS2ST1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA14", "HSPA1B", "HSPA2", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPB1", "HSPBP1", "HSPD1", "HSPE1", "HSPH1", "HTATSF1", "HTT", "HUS1", "HUWE1", "HYOU1", "IARS", "IARS2", "IBA57", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDI1", "IFIT5", "IFT27", "IGBP1", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IK", "IKBIP", "ILF2", "ILF3", "ILK", "ILKAP", "ILVBL", "IMMT", "IMP3", "IMPDH1", "IMPDH2", "INA", "INF2", "INTS13", "INTS14", "INTS3", "INTS7", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IRS4", "IST1", "ISYNA1", "ITCH", "ITGB1", "ITPA", "IVD", "IWS1", "JUP", "KARS", "KAT7", "KCTD12", "KCTD5", "KDELC2", "KDELR1", "KDM1A", "KDM1B", "KDM2A", "KDM3B", "KDSR", "KHDRBS1", "KHDRBS3", "KHSRP", "KIAA0368", "KIAA1468", "KIF11", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF3A", "KIF4A", "KIF5B", "KIFBP", "KIFC1", "KLC1", "KLC2", "KPNA1", "KPNA2", "KPNA3", "KPNA6", "KPNB1", "KRI1", "KTN1", "KYAT3", "L2HGDH", "LAMP1", "LAMP2", "LAMTOR1", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LAS1L", "LASP1", "LBR", "LDHA", "LDHB", "LDLR", "LEMD2", "LEMD3", "LETM1", "LGALS3", "LGALS3BP", "LGMN", "LIG1", "LIG3", "LIMA1", "LIPA", "LLGL1", "LMAN1", "LMAN2", "LMNA", "LMNB1", "LNPEP", "LNPK", "LONP1", "LPCAT1", "LPP", "LRBA", "LRPAP1", "LRPPRC", "LRRC40", "LRRC47", "LRRC59", "LSM6", "LSM7", "LSM8", "LSS", "LTA4H", "LTV1", "LUC7L2", "LYAR", "LYPLA1", "LZTFL1", "M6PR", "MACF1", "MAD1L1", "MAD2L1", "MAGED2", "MAGT1", "MAIP1", "MAK16", "MAP1B", "MAP1S", "MAP2K1", "MAP2K2", "MAP2K3", "MAP4", "MAPK1", "MAPK14", "MAPRE1", "MAPRE2", "MARC1", "MARCKS", "MARS", "MARS2", "MASTL", "MAT2A", "MAT2B", "MATR3", "MAU2", "MAVS", "MBNL1", "MBOAT7", "MCAT", "MCCC1", "MCCC2", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCMBP", "MCTS1", "MCU", "MCUR1", "MDC1", "MDH1", "MDH2", "MDN1", "ME2", "MEAF6", "MECP2", "MED1", "MED24", "MESD", "METAP1", "METTL13", "MFAP1", "MFN1", "MFN2", "MFSD5", "MGEA5", "MGME1", "MGST2", "MGST3", "MIA2", "MIA3", "MICU1", "MICU2", "MID1", "MIF", "MIGA1", "MINPP1", "MIOS", "MIPEP", "MKI67", "MLEC", "MMAB", "MMS19", "MOGS", "MON2", "MORF4L1", "MOSPD2", "MOV10", "MPDU1", "MPHOSPH10", "MPI", "MPP1", "MPP2", "MPP6", "MPRIP", "MPST", "MPV17L2", "MRC2", "MRE11", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL14", "MRPL15", "MRPL19", "MRPL20", "MRPL37", "MRPL43", "MRPL44", "MRPL47", "MRPL58", "MRPL9", "MRPS15", "MRPS17", "MRPS2", "MRPS27", "MRPS30", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRTO4", "MSH2", "MSH3", "MSH6", "MSI1", "MSMO1", "MSN", "MSTO1", "MTA1", "MTA2", "MTAP", "MTBP", "MTCH1", "MTCH2", "MTDH", "MTFP1", "MTHFD1", "MTHFD1L", "MTHFD2", "MTOR", "MTPAP", "MTPN", "MTR", "MTX1", "MTX2", "MUT", "MYBBP1A", "MYCBP", "MYDGF", "MYEF2", "MYG1", "MYH10", "MYH14", "MYH9", "MYL6", "MYO1B", "MYO1D", "MYO6", "NAA10", "NAA15", "NAA25", "NAA35", "NAA40", "NAA50", "NADK2", "NAE1", "NAF1", "NAGK", "NAGLU", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NAPG", "NARS", "NASP", "NAT10", "NAXE", "NBN", "NCAPD2", "NCAPG", "NCAPH", "NCBP1", "NCBP2", "NCDN", "NCKAP1", "NCL", "NCLN", "NCOA5", "NCSTN", "NDC1", "NDRG3", "NDUFA10", "NDUFA11", "NDUFA13", "NDUFA2", "NDUFA4", "NDUFA5", "NDUFA7", "NDUFA8", "NDUFA9", "NDUFAF4", "NDUFAF7", "NDUFB10", "NDUFB11", "NDUFB3", "NDUFB4", "NDUFB5", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS7", "NDUFS8", "NDUFV1", "NDUFV2", "NECAP2", "NEFL", "NEFM", "NEK9", "NELFA", "NELFCD", "NELFE", "NEMF", "NENF", "NES", "NFKB1", "NFS1", "NHP2", "NIFK", "NIP7", "NIPSNAP2", "NISCH", "NKRF", "NKTR", "NLE1", "NLN", "NMD3", "NME1", "NME2", "NMT1", "NNT", "NOC2L", "NOC3L", "NOC4L", "NOL10", "NOL11", "NOL6", "NOL8", "NOL9", "NOLC1", "NONO", "NOP10", "NOP14", "NOP16", "NOP2", "NOP56", "NOP58", "NOP9", "NOSIP", "NPC1", "NPEPPS", "NPLOC4", "NPM1", "NRBP1", "NRDC", "NSA2", "NSD2", "NSDHL", "NSF", "NSFL1C", "NSUN2", "NSUN5", "NT5C2", "NT5C3B", "NT5DC1", "NT5DC2", "NTMT1", "NUB1", "NUBP2", "NUBPL", "NUCB1", "NUCB2", "NUCKS1", "NUDC", "NUDCD2", "NUDT1", "NUDT21", "NUDT5", "NUDT9", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP160", "NUP188", "NUP205", "NUP210", "NUP214", "NUP35", "NUP37", "NUP50", "NUP54", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NUTF2", "NVL", "NXF1", "NXN", "OAT", "OCIAD1", "OCLN", "OGDH", "OGT", "OLA1", "OPA1", "OPA3", "OSBP", "OSBPL11", "OSBPL6", "OSBPL8", "OSBPL9", "OSGEP", "OTUB1", "OXA1L", "P3H1", "P3H4", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PACSIN3", "PAF1", "PAFAH1B1", "PAFAH1B3", "PAICS", "PAK1", "PAK1IP1", "PAK2", "PALLD", "PANK4", "PAPSS1", "PARK7", "PARN", "PARP1", "PARP2", "PASK", "PBK", "PBRM1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCID2", "PCK2", "PCLAF", "PCM1", "PCMT1", "PCNA", "PCNP", "PCYOX1", "PDCD11", "PDCD4", "PDCD5", "PDCD6", "PDCD6IP", "PDCL3", "PDE12", "PDE4DIP", "PDE6D", "PDHA1", "PDHB", "PDIA3", "PDIA4", "PDIA6", "PDK3", "PDLIM1", "PDLIM5", "PDLIM7", "PDS5A", "PDS5B", "PDXK", "PEBP1", "PECR", "PEF1", "PELO", "PELP1", "PEPD", "PES1", "PEX11G", "PEX14", "PEX19", "PEX5", "PFAS", "PFDN2", "PFDN4", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGP", "PGRMC1", "PGRMC2", "PHB", "PHB2", "PHF5A", "PHF6", "PHF8", "PHGDH", "PI4K2A", "PI4KB", "PICALM", "PIGK", "PIGS", "PIH1D1", "PIK3C3", "PIN1", "PIN4", "PINX1", "PIP4K2C", "PIR", "PISD", "PITHD1", "PITPNA", "PITPNB", "PITRM1", "PKM", "PKMYT1", "PKN1", "PKN2", "PLA2G15", "PLAA", "PLBD2", "PLCG1", "PLD3", "PLD6", "PLEC", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLRG1", "PLS3", "PM20D2", "PMPCA", "PMPCB", "PNN", "PNP", "PNPLA8", "PNPT1", "POFUT1", "POGZ", "POLA1", "POLA2", "POLD1", "POLDIP2", "POLDIP3", "POLE", "POLE3", "POLE4", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2A", "POLR2G", "POLR2L", "POLR3A", "POLRMT", "PON2", "POP1", "POR", "PPA2", "PPAN", "PPAT", "PPFIA1", "PPIB", "PPID", "PPIE", "PPIF", "PPIH", "PPIL1", "PPIL4", "PPM1G", "PPME1", "PPOX", "PPP1CA", "PPP1CB", "PPP1R10", "PPP1R12A", "PPP1R7", "PPP1R8", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP4R3A", "PPP5C", "PPP6C", "PPT1", "PPT2", "PQBP1", "PRAF2", "PRC1", "PRCC", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PREP", "PREPL", "PRIM1", "PRIM2", "PRKACA", "PRKAG1", "PRKAR1A", "PRKAR2A", "PRKCSH", "PRKDC", "PRKRA", "PRMT1", "PRMT3", "PRMT5", "PRMT9", "PRPF19", "PRPF3", "PRPF31", "PRPF38B", "PRPF39", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPS2", "PRPSAP1", "PRPSAP2", "PRRC1", "PRRC2C", "PSAP", "PSAT1", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD6", "PSMD7", "PSMD8", "PSME1", "PSME2", "PSME3", "PSME4", "PSMF1", "PSMG1", "PSMG3", "PSPC1", "PTBP1", "PTBP2", "PTCD1", "PTCD3", "PTDSS1", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK7", "PTPA", "PTPN1", "PTRH2", "PUF60", "PUM1", "PUM3", "PURA", "PUS7", "PWP1", "PWP2", "PXMP2", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QDPR", "QKI", "QRSL1", "RAB10", "RAB11B", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB1B", "RAB24", "RAB34", "RAB3GAP1", "RAB3GAP2", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RAB8A", "RAB8B", "RAB9A", "RABEP1", "RABEPK", "RABGAP1", "RAC1", "RACK1", "RAD21", "RAD23A", "RAD23B", "RAD50", "RAD9A", "RAE1", "RAI14", "RALA", "RALB", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP9", "RANGAP1", "RAP1GDS1", "RAPGEF2", "RARS", "RARS2", "RAVER1", "RBBP5", "RBBP6", "RBM10", "RBM12", "RBM12B", "RBM14", "RBM17", "RBM19", "RBM22", "RBM25", "RBM26", "RBM27", "RBM28", "RBM3", "RBM39", "RBM4", "RBM42", "RBM4B", "RBM5", "RBM8A", "RBMX", "RBMXL1", "RBPMS", "RCC1", "RCC2", "RCL1", "RCN1", "RDH11", "RDH13", "RDH14", "RDX", "RECQL", "REEP5", "REPS1", "RER1", "RETSAT", "REXO2", "REXO4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RFX1", "RHEB", "RHOA", "RHOG", "RHOT1", "RIC8A", "RIDA", "RIF1", "RINT1", "RIOX2", "RIPK1", "RMDN1", "RNASEH2A", "RNASET2", "RNF14", "RNF20", "RNF219", "RNF40", "RNH1", "RNPEP", "RNPS1", "ROCK2", "RP2", "RPA1", "RPA2", "RPF2", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPN1", "RPN2", "RPP30", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RRBP1", "RRM1", "RRM2", "RRP1", "RRP12", "RRP15", "RRP1B", "RRP8", "RRS1", "RSF1", "RSL1D1", "RSU1", "RTCB", "RTN2", "RTN3", "RTN4", "RTN4IP1", "RTRAF", "RUFY1", "RUVBL1", "RUVBL2", "S100A10", "S100A11", "S100A13", "SACM1L", "SAE1", "SAFB", "SAFB2", "SAMHD1", "SAMM50", "SAP130", "SAP18", "SAR1A", "SARNP", "SARS", "SARS2", "SART1", "SART3", "SBDS", "SC5D", "SCAF1", "SCAF4", "SCAMP1", "SCAMP2", "SCAMP3", "SCARB1", "SCARB2", "SCCPDH", "SCD", "SCFD1", "SCML2", "SCO1", "SCO2", "SCP2", "SCPEP1", "SCRIB", "SCRN1", "SDF4", "SDHA", "SDHB", "SEC11A", "SEC16A", "SEC22B", "SEC23A", "SEC23B", "SEC23IP", "SEC24A", "SEC24B", "SEC24C", "SEC31A", "SEC61A1", "SEC61B", "SEC62", "SEC63", "SEH1L", "SEL1L", "SENP3", "SEPHS1", "SEPT11", "SEPT2", "SEPT7", "SEPT9", "SERBP1", "SERPINB6", "SERPINH1", "SET", "SETD2", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFSWAP", "SFXN1", "SFXN4", "SGPL1", "SGTA", "SH3GL1", "SH3GLB1", "SH3GLB2", "SHCBP1", "SHMT1", "SHMT2", "SHOC2", "SHTN1", "SIGMAR1", "SIRT1", "SKIV2L", "SKIV2L2", "SKP1", "SKP2", "SLAIN1", "SLC16A1", "SLC19A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A17", "SLC25A20", "SLC25A22", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A33", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A4", "SLC29A1", "SLC2A1", "SLC33A1", "SLC35A4", "SLC35B2", "SLC35F2", "SLC3A2", "SLC7A1", "SLC9A3R1", "SLFN11", "SLIRP", "SLIT2", "SLK", "SLTM", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCC1", "SMARCC2", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC6", "SMCHD1", "SMN1*", "SMNDC1", "SMPD4", "SMU1", "SMYD3", "SMYD4", "SNAP23", "SNAP29", "SND1", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPC", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNU13", "SNW1", "SNX1", "SNX12", "SNX17", "SNX2", "SNX27", "SNX3", "SNX5", "SNX6", "SNX9", "SOAT1", "SOD2", "SON", "SORD", "SORT1", "SPAG9", "SPART", "SPC24", "SPC25", "SPCS2", "SPECC1L", "SPEN", "SPOUT1", "SPPL2A", "SPR", "SPTAN1", "SPTBN1", "SPTBN2", "SPTLC1", "SPTLC2", "SQLE", "SQSTM1", "SREK1", "SRI", "SRM", "SRP14", "SRP54", "SRP68", "SRP72", "SRP9", "SRPK1", "SRPRA", "SRPRB", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF3", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSNA1", "SSR1", "SSRP1", "STAG1", "STAG2", "STAM", "STAMBP", "STARD3", "STARD3NL", "STAT1", "STAT3", "STAU1", "STAU2", "STIP1", "STK4", "STMN1", "STOM", "STOML2", "STRAP", "STRBP", "STRN", "STT3A", "STUB1", "STX12", "STX18", "STX5", "STX7", "STXBP3", "STXBP4", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGP2", "SUGT1", "SUN1", "SUPT16H", "SUPT5H", "SUPT6H", "SUPV3L1", "SURF4", "SURF6", "SUZ12", "SV2A", "SYAP1", "SYMPK", "SYNCRIP", "SYNE2", "SYNGR2", "SYNJ2BP", "TACC3", "TAF15", "TAGLN2", "TALDO1", "TAMM41", "TARDBP", "TARS", "TARS2", "TBC1D10B", "TBC1D13", "TBC1D15", "TBC1D4", "TBC1D9B", "TBCA", "TBCC", "TBCD", "TBCE", "TBL3", "TBRG4", "TCAF1", "TCEA1", "TCERG1", "TCOF1", "TCP1", "TDP2", "TDRKH", "TECR", "TELO2", "TERF2IP", "TEX264", "TFAM", "TFCP2", "TFG", "TFRC", "THOC1", "THOC2", "THOC3", "THOC6", "THOP1", "THRAP3", "THUMPD1", "THUMPD3", "TIA1", "TIAL1", "TIGAR", "TIMM10", "TIMM17A", "TIMM17B", "TIMM23", "TIMM44", "TIMM50", "TIMM8B", "TIPRL", "TJP1", "TK1", "TKFC", "TKT", "TLN1", "TM9SF3", "TMCO1", "TMED10", "TMED2", "TMED5", "TMED7", "TMED9", "TMEM109", "TMEM126A", "TMEM14C", "TMEM165", "TMEM199", "TMEM201", "TMEM214", "TMEM230", "TMEM33", "TMEM43", "TMEM97", "TMOD1", "TMOD3", "TMTC3", "TMX1", "TMX2", "TMX3", "TNKS1BP1", "TNPO1", "TNPO2", "TNPO3", "TOE1", "TOLLIP", "TOMM20", "TOMM22", "TOMM34", "TOMM40", "TOMM5", "TOMM70", "TOP1", "TOP2A", "TOP2B", "TOR1AIP1", "TP53", "TP53BP1", "TPD52", "TPD52L2", "TPI1", "TPM1", "TPM3", "TPM4", "TPP1", "TPP2", "TPR", "TPT1", "TPX2", "TRA2A", "TRA2B", "TRAM1", "TRAP1", "TRAPPC5", "TRIM21", "TRIM24", "TRIM25", "TRIM26", "TRIM27", "TRIM28", "TRIM33", "TRIM35", "TRIP12", "TRIP13", "TRIR", "TRMT10C", "TRMT1L", "TROVE2", "TSFM", "TSG101", "TSN", "TSNAX", "TSPAN6", "TSR1", "TTC1", "TTC19", "TTC26", "TTC37", "TTC4", "TTF2", "TTLL12", "TTYH3", "TUBB", "TUBB2A", "TUBB2B", "TUBB4A", "TUBB4B", "TUBB6", "TUBGCP2", "TUBGCP3", "TUFM", "TWF1", "TWF2", "TXLNA", "TXLNG", "TXNDC12", "TXNDC17", "TXNDC5", "TXNRD1", "TYMS", "U2AF1", "U2AF2", "U2SURP", "UAP1", "UBA1", "UBA2", "UBA3", "UBA6", "UBAP2L", "UBE2G2", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2O", "UBE2S", "UBE3A", "UBE4B", "UBLCP1", "UBQLN4", "UBR4", "UBR5", "UBTF", "UBXN1", "UCHL5", "UFC1", "UFD1", "UFL1", "UFM1", "UGDH", "UGGT1", "UGP2", "UHRF1", "UMPS", "UNC119", "UNC119B", "UNC45A", "UNG", "UPF1", "UQCC1", "UQCR10", "UQCRB", "UQCRC1", "UQCRC2", "UQCRQ", "URB1", "UROD", "USO1", "USP10", "USP11", "USP14", "USP15", "USP39", "USP47", "USP48", "USP5", "USP7", "USP9X", "UTP11", "UTP14A", "UTP15", "UTP18", "UTP20", "UTP3", "UTP4", "UTP6", "UTRN", "VAMP7", "VANGL1", "VAPA", "VAPB", "VARS1", "VARS2", "VAT1", "VBP1", "VCL", "VCP", "VDAC1", "VDAC2", "VDAC3", "VIM", "VIPAS39", "VIRMA", "VKORC1L1", "VMP1", "VPS18", "VPS26A", "VPS29", "VPS33A", "VPS33B", "VPS35", "VPS4B", "VPS52", "VRK1", "VTA1", "VTI1B", "WAPL", "WARS", "WASHC4", "WBP11", "WBP2", "WDHD1", "WDR1", "WDR18", "WDR3", "WDR36", "WDR41", "WDR43", "WDR46", "WDR5", "WDR6", "WDR61", "WDR75", "WDR77", "WDR82", "WDR91", "WFS1", "WIPI2", "WIZ", "WNK1", "WTAP", "XAB2", "XPNPEP1", "XPNPEP3", "XPO1", "XPO5", "XPO7", "XPOT", "XRCC1", "XRCC5", "XRCC6", "XRN2", "YARS", "YARS2", "YBX1", "YBX3", "YEATS4", "YKT6", "YLPM1", "YME1L1", "YRDC", "YTHDC1", "YTHDC2", "YTHDF2", "YTHDF3", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2", "ZC3H11A", "ZC3H14", "ZC3H15", "ZC3H18", "ZC3H7A", "ZC3HAV1", "ZC3HC1", "ZCCHC3", "ZCCHC8", "ZFYVE16", "ZMPSTE24", "ZNF207", "ZNF24", "ZNF281", "ZNF318", "ZNF326", "ZNF622", "ZNF638", "ZPR1", "ZW10", "ZYX"], "leading_proteins": ["AASDHPPT", "ABCB1", "ABCB7", "ABCD3", "ABHD10", "ABHD12", "ACAD9", "ACAT2", "ACOT7", "ACOT8", "ACOX1", "ACOX3", "ACP6", "ACSL3", "ACSL4", "ACTN4", "ADA", "ADH5", "ADK", "ADNP", "ADPGK", "AFG3L2", "AGK", "AHCYL1", "AIFM1", "AKAP8", "AKAP8L", "AKT2", "ALDH1B1", "ALDH3A2", "ALG1", "AMOT", "ANAPC5", "ANKLE2", "ANKRD50", "APC", "APOL2", "APOOL", "APP", "APPL1", "ARHGAP17", "ARL6IP1", "ARL6IP5", "ASNA1", "ASPH", "ATAD1", "ATAD3A", "ATAD3B", "ATE1", "ATG7", "ATL2", "ATP13A1", "ATP1A1", "ATP2A2", "ATP2B1", "ATP5L", "ATP6V0A1", "ATP6V0A2", "ATPIF1", "AUP1", "B3GALT6", "BAG4", "BAG5", "BAG6", "BAIAP2", "BCAP31", "BCAS3", "BCL2L13", "BCS1L", "BICD2", "BLVRA", "BLVRB", "BNIP1", "BSG", "BUB1", "BUB1B", "C12orf73", "C19orf70", "CAMK2G", "CARM1", "CASK", "CASP3", "CASP6", "CASP7", "CCDC134", "CCDC47", "CCNB1", "CD47", "CDC37", "CDCA5", "CDK1", "CDK4", "CDK5RAP3", "CENPV", "CERS1", "CERS2", "CHCHD3", "CHERP", "CHID1", "CHKA", "CHORDC1", "CHST14", "CISD1", "CLCC1", "CLCN3", "CLGN", "CLN5", "CLPTM1", "CLUH", "CNNM3", "CNOT9", "COA3", "COASY", "COG2", "COMT", "COPB2", "COPS5", "COPS6", "COPS7B", "COX15", "COX4I1", "COX7A2", "CPD", "CPOX", "CPSF3", "CPT2", "CRTAP", "CSNK1A1", "CTBP1", "CTPS1", "CTR9", "CTSA", "CTSC", "CUL3", "CYB5B", "CYB5D2", "CYFIP1", "CYP51A1", "DAGLB", "DAZAP1", "DCAKD", "DCP1A", "DCTPP1", "DCUN1D4", "DCUN1D5", "DDI2", "DDX1", "DDX17", "DDX3X", "DDX5", "DDX56", "DERL1", "DHCR24", "DHCR7", "DHPS", "DHX36", "DHX9", "DICER1", "DNAJA2", "DNAJC10", "DNAJC2", "DNAJC7", "DNM1L", "DNM2", "DOLPP1", "DPP9", "DSG2", "DUSP9", "DYNC1LI1", "EBP", "ECE1", "ECH1", "EIF2B2", "EIF2B3", "EIF2B5", "EIF3E", "EMD", "EPHX1", "ERCC2", "ERCC3", "ERGIC2", "ERGIC3", "ERLIN2", "ERMP1", "ERO1A", "EXO1", "EXOC4", "EXOSC3", "EXOSC7", "EXOSC8", "EZR", "FADS2", "FAH", "FAM162A", "FAM208A", "FAM8A1", "FAM98B", "FASN", "FDFT1", "FERMT2", "FGFR1OP", "FIS1", "FKBP14", "FKBP1A", "FKBP7", "FLAD1", "FLOT1", "FLOT2", "FMR1", "FNTB", "FOXC1", "FOXRED1", "FUCA1", "FUCA2", "FUNDC2", "FUS", "G6PD", "GAA", "GALNT7", "GBA", "GBF1", "GCLM", "GDAP1", "GGCX", "GHITM", "GIGYF2", "GINS2", "GINS3", "GINS4", "GLB1", "GLG1", "GLMN", "GLUD1", "GMPPB", "GNAI2", "GNAI3", "GOLPH3", "GOLT1B", "GPAM", "GPD2", "GPHN", "GPR107", 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305.0218446601942 1.8626549185660248 0.4346737740195964 40.114822105305365 33.029069404441934 2.648813561163414 0.4525721946789457 2.8824279889857635e-16 0.0007350383105797 1.50628905918468e-07 3.935894528842274e-15 9.786946415826433e-22 +Organelle subcompartment 117 310 6.026677044676704 1.673649603462158e-09 115.97815533980582 370.4077669902912 1.8466078375892352 0.461199583276842 45.24176702976874 43.040100266333 2.697642340677977 0.4541841641473397 6.6617781133284955e-15 0.0005104284725754 1.233059362857396e-06 3.2399558133854106e-15 2.6890550575547425e-21 +Endoplasmic reticulum 148 413 5.801032571944687 6.590779501615258e-09 139.71116504854368 475.50728155339806 1.972579372344309 0.4597126503683645 50.29410175615224 47.94654634280014 2.8130551221954065 0.458598772128197 7.702775378132908e-15 0.0106644614070438 7.702281281763015e-06 2.8360167984768664e-16 1.393892263419898e-24 +Intrinsic component of organelle membrane 51 113 4.762367823309408 1.9133451956143688e-06 52.51699029126213 129.34223300970874 2.0732064315361294 0.2796588394070637 24.692225942786415 15.820346456508432 2.8130846896968285 0.39829365000917 5.428464515304961e-09 0.0030261455975404 3.271378498438198e-05 2.745103927419663e-07 1.9549678083761576e-13 +Organelle inner membrane 67 212 4.687578531463541 2.7645662894482115e-06 79.6747572815534 237.5995145631068 1.5941979045672914 0.3906136455525962 32.81710191865129 21.467005610038825 2.570753705211445 0.4244355950981394 8.955329838805576e-09 6.540596558644666e-06 4.4604314889934664e-08 3.695582188761182e-07 1.3920830774077678e-17 +Mitochondrial envelope 97 277 4.4860354043111785 7.256068935923565e-06 98.51456310679612 309.05582524271847 1.3784407074331837 0.4315621435689855 37.853540978552445 29.592036616547553 2.6690149272426917 0.4358105924461398 1.2295291748162411e-08 1.0875494739562949e-06 6.136173966580436e-09 2.31087701255274e-08 2.735628151992902e-20 +Outer membrane 32 82 3.961100195085725 7.460521692914668e-05 28.936893203883496 87.79611650485437 1.4859238244628277 0.3236686433663402 11.632349354832256 8.24751710010496 1.9336855473946637 0.38878066573106 5.378127877888428e-06 0.0016900813978939 9.636026434398862e-06 3.730477612686012e-07 1.4734852106787594e-12 +Intrinsic component of endoplasmic reticulum membrane 27 46 3.752284924645633 0.0001752301462158 21.439320388349515 53.03155339805825 1.5445183869163015 0.2945609219212759 9.936629672422429 6.151523176643304 2.1054078800196185 0.3580268322643601 1.81884762385096e-05 0.1225807784723296 0.0075508250565443 5.2829178733530186e-05 2.672215930305138e-10 +Golgi apparatus 69 247 3.525554572553712 0.0004225970972473 79.29126213592232 307.80825242718447 1.0941692666231844 0.5225509759640199 24.90716006851961 39.34912971804267 1.7376904428153446 0.4394682295132952 0.2987039798386864 0.2089324085709392 0.5261381322464322 0.0700806378846965 0.00150215390796 +Envelope 141 432 3.348660800545585 0.0008120314428365 133.55825242718447 476.99271844660194 1.1125762168925015 0.4931727688685032 47.82674034566458 40.415168802184624 2.6300132137901633 0.4489464989697134 1.652867068603085e-09 8.664279928000202e-06 3.3254359372248104e-08 2.728899720154654e-09 3.1390269434472274e-24 +Intrinsic component of mitochondrial membrane 14 44 3.3192337378188976 0.0009026484043046 20.225728155339805 46.883495145631066 1.6360090381123027 0.2606204408334349 9.735582728924424 5.567853242112672 2.0682718238883013 0.3438986948818692 0.0005751534655832 0.0005428611587646 0.0001128728628543 0.002958524345255 9.967539215029317e-07 +Intrinsic component of mitochondrial inner membrane 10 28 3.2586987729129846 0.0011192443846197 13.946601941747574 31.446601941747577 1.7062420859184484 0.2149692261988765 6.992163651608136 3.3601842163433866 1.8185871159494191 0.3070405082296492 3.091108202434839e-05 9.216009865795702e-05 8.093823153610318e-06 0.0001846255682835 2.186216052021089e-05 +Membrane protein complex 64 253 3.1950542484495763 0.0013980455935984 80.6747572815534 286.40291262135923 0.8072324880333213 0.5482017098759524 27.14508025817277 25.65052264389531 1.8803092756171496 0.4277745875695662 0.0001955337652666 5.598590959146687e-05 1.915564447261661e-05 0.000772918275991 4.925950693254503e-08 +Inner mitochondrial membrane protein complex 23 71 3.110567377815268 0.0018672829016685 27.97087378640777 75.4635922330097 1.520604987560478 0.2664687480104057 12.043574857699111 6.447783897817093 2.3558486082891616 0.3692317407906862 0.0001459452106108 0.000407082511055 5.0296947644184965e-06 0.000353075219544 1.8523288432238533e-08 +Golgi membrane 34 105 3.065766175998186 0.0021711303112468 41.28398058252427 131.19174757281553 1.6327747521284677 0.3511039607499193 15.277988344159814 17.44963987873233 1.926180921267262 0.4033858283713009 0.1539345358435302 0.335023850489542 0.2311788058225983 0.0535779405349757 0.0094094218524768 +Coated vesicle 20 78 2.8522246280389125 0.0043414409687958 21.15776699029126 89.28398058252426 0.7996411773181966 0.4463095457932411 7.252509633536616 8.542551157088123 1.3406722753228342 0.3892656029628454 0.0308804312902767 0.2515369543584532 0.0457999816702013 0.0244236045811103 0.0001184103633671 +Microbody membrane 12 27 2.8199673318453744 0.0048028538741724 9.83980582524272 26.8373786407767 1.0322166739723002 0.3740701224912098 5.101262737371427 4.075770333088885 1.3138416014090577 0.3534887732287703 0.0005698448945098 1.0 1.0 0.0024554723849656 1.4960350244519804e-05 +Mitochondrial protein containing complex 34 136 2.5148909577098912 0.0119069204268258 45.62621359223301 153.59708737864077 0.8032126729603613 0.4024101172023991 21.080430630469312 12.423857071229754 2.191669513941161 0.4117346592056412 0.0002343872155079 0.0001973261442842 6.200020533418191e-06 0.0013575339273918 2.387078801921616e-08 +Endoplasmic reticulum golgi intermediate compartment membrane 7 21 2.4954425359849366 0.0125800129357969 10.49271844660194 25.839805825242717 1.5441023898993702 0.2324243418613106 5.505729177420246 3.7718384126099376 1.49831312620529 0.2965572765953523 0.0177456933272394 1.0 0.0995728547031488 0.0104048104957299 0.0048615078505965 +Outer mitochondrial membrane protein complex 6 15 2.418336547814107 0.0155916486821059 7.157766990291262 15.730582524271844 1.3245491566248977 0.2112996285983387 3.5767402396348245 0.8689557679680192 1.477430451036954 0.2853006280851536 0.0004132401328629 0.0040679264544396 3.5959740301631905e-05 0.0011993766429203 2.789873905099777e-05 +Microbody 17 49 2.3358514725820063 0.0194989838731696 14.5873786407767 55.157766990291265 0.5308798958236631 0.4622505798174944 6.656600193656261 6.967459933597681 1.141402376279513 0.3502304815174672 4.223720526626204e-05 0.103882057076417 0.0990612642216925 9.622027583092228e-05 9.129336059512885e-06 +Cis golgi network 2 10 2.3266556378485865 0.0199836007420741 5.446601941747573 14.91747572815534 1.304763677188147 0.2415633778835601 2.9087352716231463 3.2280604409731746 1.23405443481851 0.2890539664507128 0.0337694839651459 0.01497108596825 0.0548237001435711 0.0678108138951911 0.2957464229501276 +External side of plasma membrane 6 18 2.296685776967517 0.0216367013977909 6.856796116504855 22.03640776699029 0.7617836494895279 0.3205100812766187 3.0547396608098576 3.343757364022431 1.3549821177336052 0.303342613906597 0.3050876998448076 1.0 0.0838856775027136 0.2553345142430238 0.2586907895437586 +Nuclear inner membrane 7 19 2.226138285584941 0.0260049201797942 7.347087378640777 20.57281553398058 1.3204335588742686 0.2519451141048848 3.6006224195129035 1.9968516080603145 1.2188770932171689 0.2896682474252494 0.000941956632969 0.1835089509173778 0.0625314301217693 0.0032788281256578 0.0008199687519457 +Proton transporting two sector atpase complex 3 20 2.197732573264424 0.0279681688793727 7.116504854368932 22.25728155339806 1.0735578367707936 0.2848832687688338 3.2910616544032156 1.9833825153714253 1.32099194967518 0.2987458873835026 0.0032418992438421 0.0115082778780227 0.000310136398558 0.0088087297166582 0.0233089974379561 +Copii coated er to golgi transport vesicle 9 30 2.136533129687397 0.0326359835785807 10.810679611650484 32.4247572815534 0.9209697551014924 0.3949407296339237 5.01338814607213 3.9617918728777735 1.2509556054930144 0.3456813773327062 0.1232030318778912 1.0 0.4810063700036922 0.0789974698724344 0.0014020336345134 +Endocytic vesicle membrane 9 36 2.133012715399116 0.0329236831342312 11.41019417475728 40.75728155339806 0.6528171904926832 0.3529092384633215 4.825015011915381 4.780047567333447 1.5638167276319088 0.3380752375601685 0.0556254304278377 0.0001977817204563 0.0047886998768676 0.0564557710967487 0.021690291144078 +Proton transporting two sector atpase complex proton transporting domain 2 8 2.129773710585575 0.0331903001116968 4.053398058252427 10.283980582524272 1.020958321179617 0.2307004649223604 1.8491832641634656 1.1862626633334956 1.3576055733210162 0.273185751006507 0.0023122296118813 0.0022827689145391 0.0003712110430798 0.0051503840765812 0.0338099842169397 +Mitochondria associated endoplasmic reticulum membrane 6 9 2.1063316975525943 0.0351755497697396 4.191747572815534 9.240291262135925 0.7019541594808174 0.4009163152547425 2.0831338076447135 1.0418560326821893 1.1194321867771957 0.3336055532093068 0.041818515662187 1.0 0.1611939416425752 0.0693365470158766 0.0013613651941044 +Respirasome 16 42 2.097322522823033 0.0359650343925395 15.08495145631068 43.37378640776699 1.2524823540042158 0.2922262294299136 6.290312072426717 4.489587979561489 1.7783434517583476 0.3462844006183536 0.0695876884162124 0.0627750690965546 0.0092927708056161 0.0551022953292233 1.2912647045240088e-05 +Organelle membrane contact site 8 15 2.095130681282035 0.0361593772098203 6.817961165048544 16.400485436893202 0.815819301321945 0.3904411977369264 3.451940177462974 2.047328298639296 1.2919706717077657 0.3464717655445403 0.0254908890839722 1.0 0.2897038292296705 0.0520565373494006 0.0012811473170246 +Recycling endosome 13 34 2.085332452425208 0.0370391336020645 11.66504854368932 38.48300970873787 0.3314123370484901 0.5655153978404952 4.733627044629046 5.712973030267684 1.060328776827888 0.3489425897551162 0.495447552617099 0.5051564551774747 0.7594724574790849 0.468209771238903 0.0506400413851923 +Vacuole 55 195 2.082267792064212 0.0373180160921811 55.029126213592235 212.35679611650485 0.7895788564169173 0.4204713883128338 16.092847298969616 21.031446114270427 2.221429361906059 0.4148180554719883 0.000627242896229 0.0526139961090794 0.0475881371844934 0.0005658783288713 1.0690415033965276e-07 +Lipid droplet 8 29 2.081951972002257 0.0373468568765122 7.313106796116505 30.72087378640777 0.9597061621709796 0.3916106255858687 3.663189105886808 2.181620314734523 1.1934081113966928 0.3497541884861006 0.0321777538091352 1.0 0.1345193233748266 0.0001807158753055 0.0003102982974167 +Endoplasmic reticulum golgi intermediate compartment 9 42 2.0390715323743644 0.0414428888903399 14.888349514563108 49.49271844660194 1.4759277407874345 0.3201471070907981 6.47003250199477 5.053350843348441 1.420924643396655 0.3585240832471577 0.0333379855712201 1.0 0.246227356039959 0.0096006639064149 0.0207966076304104 +Endosome 44 188 2.02040137395214 0.0433417710320185 49.68446601941748 210.85679611650485 0.3589512364806963 0.6263779709054735 15.417095902733692 27.960293924368397 1.2603534839168704 0.3964197633252465 0.0446858769360783 0.0441955770558895 0.1282782824548827 0.0700888363071022 0.0163906435515589 +Proton transporting v type atpase complex 2 11 1.99629650666358 0.0459016580754112 3.1723300970873787 11.17233009708738 1.083137374920517 0.3054753623634815 1.8106779848505148 1.1913569842207026 0.9186852151104662 0.2868810804648729 0.0033641802428605 0.0029386578360865 0.0005470061355849 0.0074273483269255 0.0470360579614364 +Rough endoplasmic reticulum 8 33 1.9721856601390544 0.0485884160521947 8.516990291262136 34.51699029126213 0.6279779058801568 0.506302031213321 4.715930723848554 2.6644372563657086 1.002611026388539 0.3540125587222381 0.0177456933272394 1.0 1.0 4.818233124362865e-05 0.0002790542910114 diff --git a/msigdb_gocc/metrics.json b/msigdb_gocc/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..26dac044ac90b15f9462354acec6cd0fd065b517 --- /dev/null +++ b/msigdb_gocc/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2734, + "annotations_size": 884, + "title": "Average number of proteins per term", + "value": 25.783936651583712 +} \ No newline at end of file diff --git a/msigdb_gocc/paths.json b/msigdb_gocc/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..51c0f99084a9e067e5d0635a0ecd387d05442836 --- /dev/null +++ b/msigdb_gocc/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/msigdb_gocc/fragment/C166/C166_val_log2fc"} \ No newline at end of file diff --git a/msigdb_gocc/result.tsv b/msigdb_gocc/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..75eee5fd23b718f1d3836e8262a2546f383acd41 --- /dev/null +++ b/msigdb_gocc/result.tsv @@ -0,0 +1,241 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Nuclear outer membrane endoplasmic reticulum membrane network 0.5632240722450654 6.249738023883783 4.1114172316655306e-10 3.634492181902644e-07 3.634492841632329e-07 264 Q9NZ01,Q16850,P37268,Q9BQE5,O60725,Q86XL3,Q9NQC3,Q96G23,Q14108,Q15392,P43307,Q06136,P07099,Q8N511,Q9Y282,Q15125,Q9BRR6,Q96N66,Q99720,O95197,Q9HD20,P62942,Q8TB61,P30519,Q9BZF3,Q9P2W9,Q14739,O75844,Q5BJF2,Q9Y6I9,P48449,P46977,O00767,Q96RQ1,P27544,O43852,P24390,Q9UBU6,P67812,O95772,O43865,Q7Z2K6,P16615,P51648,Q96PC5,Q9BUN8,Q96A33,Q8TCT9,P16435,Q15629,P09601,Q07065,Q13190,Q14534,P22059,Q9Y5M8,Q15800,Q9UBM7,P51809,P51572,Q9UEU0,O00264,Q8N0U8,P35606,Q8IV08,P01889,Q9P035,O95470,Q70UQ0,O76024,Q86UE4,P38435,Q99442,Q9UM00,Q8TD16,Q96GC9,P48651,A1L0T0,O95487,Q53GQ0,Q6NUQ1,P57088,Q13555,Q99523,Q9BT22,O15027,O15269,P50402,Q15005,Q99640,O75845,Q9Y679,Q969V3,Q9HCU5,O60488,Q6NUQ4,O75298,Q86YN1,Q9NTJ5,Q92643,O95864,Q8TCT8,Q96S66,Q9Y320,Q9H3N1 105 +Organelle subcompartment 0.5504847746268838 6.026677044676704 1.673649603462158e-09 1.4795051571138007e-06 7.397531251722738e-07 310 Q16850,P37268,Q9BQE5,O60725,O00461,Q9NPR9,Q86XL3,Q9NQC3,Q96G23,Q14108,Q15392,P43307,Q06136,P07099,Q8N511,Q9Y282,Q15125,Q9BRR6,Q96N66,Q99720,O95197,Q9HD20,P62942,Q8TB61,P30519,Q9BZF3,Q9P2W9,Q14739,O75844,Q5BJF2,Q9Y6I9,P48449,P46977,O00767,Q96RQ1,Q9HC07,P27544,O43852,P24390,Q9UBU6,Q96A57,P67812,O95772,O43865,Q7Z2K6,P16615,P51648,Q96PC5,Q9BUN8,Q96A33,Q8TCT9,P16435,Q15629,P09601,P05067,Q07065,Q13190,Q14534,Q96L58,P22059,Q9Y5M8,P04062,Q7Z6M1,Q15800,P61006,Q9UBM7,P51809,P51572,Q9UEU0,O00264,Q8N0U8,P35606,Q8IV08,P01889,Q9P035,O95470,Q70UQ0,O76024,Q10713,Q86UE4,P38435,Q99442,Q9UM00,Q96GC9,P48651,A1L0T0,O95487,Q53GQ0,Q9H4A6,Q6NUQ1,P57088,Q13555,Q99523,Q9BT22,O15126,O15027,O15269,Q9BZG1,P50402,Q15005,Q99640,O75845,Q9Y679,Q00765,Q969V3,Q9BWS9,Q9HCU5,O60488,Q6NUQ4,O15127,O75298,P50570,Q86YN1,Q9NTJ5,Q92643,O95864,Q8TCT8 117 +Endoplasmic reticulum 0.5289444609226035 5.801032571944687 6.590779501615258e-09 5.826232126955327e-06 1.9420830267706298e-06 413 P13674,Q9NZ01,Q16850,P37268,Q9BQE5,O60725,Q86XL3,Q9NQC3,Q96G23,Q14108,Q15392,P43307,Q06136,P00367,P83881,P07099,Q8N511,P60604,Q9Y282,Q15125,Q9BRR6,Q96N66,Q99720,O95197,Q9HD20,Q9NWM8,P62942,Q8TB61,P30519,Q9BZF3,Q9P2W9,Q14739,O75844,Q5BJF2,Q14257,Q9Y6I9,P48449,P46977,O00767,Q96RQ1,Q32P28,P27544,O43852,P24390,O60506,Q9UBU6,Q96A57,O15118,Q02818,P67812,O95772,O43390,O43865,Q7Z2K6,P16615,P51648,Q96PC5,Q9BUN8,Q96A33,Q8TCT9,P16435,Q15629,P09601,P05067,Q07065,Q13190,O75503,Q14534,Q9BRK5,P22059,O15173,Q9Y5M8,P04062,Q15800,P80303,Q9UBM7,Q9UQB8,Q01105,P14618,O43681,P51809,P51572,Q9UEU0,O00264,Q8N0U8,Q92791,P35606,Q8IV08,P01889,P84157,Q9P035,O95470,P23396,Q70UQ0,O76024,Q15631,Q9Y680,Q86UE4,Q9NUL3,P38435,Q99442,Q9UM00,P53634,Q96GC9,P48651,A1L0T0,O95487,Q53GQ0,Q6NUQ1,P57088,Q13555,Q99523,Q9BT22,O15027,O15269,P50402,Q15005,Q99640,Q8TBX8,Q9Y3E0,Q8TED1,O75845,Q9Y679,Q00765,Q969V3,P61960,Q9HCU5,O60488,Q9NR31,Q6NUQ4,P36507,O75298,Q9BTY2,Q99797,Q86YN1,P27105,Q9NTJ5,Q92643,O95864,P62266,Q8TCT8,Q9H6S0,Q96S66,Q8N2G8,P52789,O15258,Q9Y320,Q9H3N1 148 +Intrinsic component of organelle membrane 0.578849271378979 4.762367823309408 1.9133451956143688e-06 0.0016899691622644 0.0004228492882309 113 Q99595,Q9Y2R0,Q9NZ01,Q8TB36,O60830,Q96HA9,O15118,P01889,Q13505,Q9Y679,Q8IWA4,Q86XL3,Q96AQ8,Q9P035,Q9BUN8,Q9NQC3,Q96A33,O95470,Q8TCT9,Q9HCU5,Q5SNT2,Q15629,O76024,P42892,O75431,Q99442,Q9UM00,Q9Y282,Q15125,Q15070,O75298,Q6P4A7,Q86YN1,Q8TB61,P57105,P57088,Q92643,Q9BWH2,Q9UBM7,Q14739,O75844,O14925,O96008,O15126,Q8TCT8,Q86Y82,Q6UXV4,Q9H3K2,O15258,O00767,P51572 51 +Organelle inner membrane 0.4985301546542346 4.687578531463541 2.7645662894482115e-06 0.0024408961345486 0.0004887753199746 212 P36551,Q99595,Q9Y2R0,Q9H845,O60830,P13073,O95168,P14406,P21912,Q9BYC9,O75306,O75027,P23786,Q9H2D1,O96000,Q9Y6M9,Q9H1E5,Q9BSK2,Q7KZN9,Q8IYU8,Q13505,Q02978,Q96AQ8,Q567V2,P23396,Q9NX14,Q70HW3,O14949,Q9H061,Q5SNT2,P82933,Q9NVA1,Q10713,O75431,Q8WWC4,P62995,Q9UDW1,Q15070,O95202,Q86Y39,Q6P4A7,Q99720,O75964,Q96IX5,P43304,P12236,Q9UBX3,Q9NYK5,Q69YU5,Q5T9A4,P40939,O43615,O60313,O43676,Q9UDX5,Q9NVI7,Q14739,O75844,Q13423,O14925,O96008,O43772,Q6UXV4,Q9H3K2,P43243,P62072,P50402 67 +Mitochondrial envelope 0.456670821678428 4.4860354043111785 7.256068935923565e-06 0.0063938599385009 0.0010690608232262 277 Q9Y619,Q99595,Q96CU9,O60830,Q12981,P21796,Q07820,Q9NS69,O75306,P23786,P45880,Q96BW9,Q8NAN2,Q9H2D1,O43169,Q13505,O43674,Q96AQ8,Q70HW3,O14949,Q9H061,Q9NZ45,O75431,Q9UDW1,Q15070,Q9HCL2,O75964,Q8N4H5,Q9UBX3,Q69YU5,O43676,Q9UDX5,Q9NZJ7,O43772,P62072,Q8WY22,Q8WWV3,Q9Y2R0,Q02978,Q567V2,P09601,Q9NQZ5,Q86Y39,Q5T9A4,Q96A26,Q9BUK6,Q8N0X7,P36551,O00264,Q9Y277,P13073,O95168,P14406,P21912,O96000,Q9Y6M9,Q9BSK2,P23396,Q99536,P82933,Q10713,Q8WWC4,O95202,Q6P4A7,Q8NBU5,P43304,Q9NYK5,Q9H4A6,P40939,O43615,O60313,Q9BWH2,Q9NVI7,Q13423,O14925,O96008,Q6UXV4,Q9H3K2,Q8N2A8,Q13057,Q8TB36,Q9H845,Q9BYC9,O75027,Q7KZN9,Q8IYU8,Q8IWA4,Q9NX14,O60488,Q9NVA1,O75323,Q96IX5,P12236,Q9P0J0,P57105,P52789,Q9Y320 97 +Outer membrane 0.5560049688410792 3.961100195085725 7.460521692914668e-05 0.0638255784286463 0.0028674352941463 82 Q13057,O00264,P50402,Q8TB36,Q9Y277,P21796,Q9NS69,P45880,O43169,Q13505,Q8IWA4,Q99536,O60488,P09601,Q9NZ45,O75431,Q9NQZ5,Q9HCL2,Q99720,Q8NBU5,Q8N4H5,O60313,Q9BWH2,Q9BUK6,Q9UBM7,Q9NZJ7,O96008,Q8N0X7,Q6UXV4,Q8WY22,Q8N2A8,Q8WWV3 32 +Intrinsic component of endoplasmic reticulum membrane 0.6347633763087486 3.752284924645633 0.0001752301462158 0.1435137565639321 0.0043028735904126 46 Q9NZ01,P01889,Q9Y679,Q86XL3,Q9P035,Q9BUN8,Q9NQC3,Q96A33,O95470,Q8TCT9,Q9HCU5,Q15629,O76024,Q99442,Q9UM00,Q9Y282,O75298,Q15125,Q86YN1,Q8TB61,P57088,Q92643,Q9UBM7,O75844,Q8TCT8,O00767,P51572 27 +Golgi apparatus 0.4061923503539146 3.5255545725537116 0.0004225970972473 0.3117855522078264 0.0080475768108744 247 Q9HC07,Q9UEU0,O43852,P50897,P24390,Q99640,Q8NCH0,Q9H9C1,Q9Y3E0,Q969S3,Q96A57,O15118,P25054,P62993,Q02818,P35606,P51790,Q8IV08,O00461,P01889,Q5VW38,Q9NPR9,Q9NX40,Q93050,P11166,O43823,O14773,Q14108,Q15392,Q9BWS9,Q92896,Q9NR31,Q6NUQ4,Q10713,O15127,P05067,P36507,Q13190,O75503,Q9UM00,Q9Y282,Q8TD16,P53634,Q96L58,O95197,Q7LGA3,P50570,Q9BRK5,P22059,Q8IZA0,Q8TB61,Q9H4A6,P50542,P04062,Q7Z6M1,Q99523,P61006,Q9P2W9,P80303,Q9UQB8,O15126,O15027,Q9BZG1,Q8N2A8,P51809,Q96RQ1,P51572,Q9H267,Q9H7Z7 69 +Envelope 0.3994429172122121 3.348660800545585 0.0008120314428365 0.5123354007093993 0.012166708397755 432 Q99595,Q9Y619,O60830,Q96CU9,P21796,Q12981,Q07820,P11802,Q9NS69,O75306,P23786,P45880,Q9H2D1,Q96BW9,Q8NAN2,Q9H1E5,O43169,Q13505,O43674,Q9BXK5,Q96AQ8,Q99567,Q9NQC3,Q70HW3,O14949,Q96BR5,Q9H061,Q96AG4,Q8NBN7,P02545,P57740,Q9NZ45,O75431,Q9UDW1,Q15125,Q15070,Q9HCL2,Q99720,O75964,Q8N4H5,Q9UBX3,Q69YU5,O43676,Q9BZF3,Q9UDX5,Q14739,O75844,Q5BJF2,Q9NZJ7,O43772,Q9BTX1,P62072,Q8WY22,Q8WWV3,Q9Y2R0,O15118,Q02978,Q567V2,Q5SNT2,P09601,P05067,Q9NQZ5,Q86Y39,O15173,Q5T9A4,Q96A26,P80303,Q9BUK6,Q9UBM7,Q8N0X7,P36551,O00264,Q9Y277,P13073,O95168,P14373,P14406,P21912,O96000,Q9Y6M9,Q9BSK2,Q96P70,Q9P035,P23396,Q99536,P82933,Q10713,Q86UE4,Q8WWC4,Q9NUL3,Q8TD16,O95202,Q6P4A7,Q8NBU5,P43304,Q9NYK5,Q9H4A6,P40939,P57088,O43615,O60313,Q8N1F7,Q8NFH4,Q99523,Q9BWH2,Q9NVI7,Q13423,P42167,O14925,O96008,Q6UXV4,Q9H3K2,P43243,Q8N2A8,P50402,Q13057,Q8TB36,Q9H845,Q9BYC9,O75027,P67809,Q7KZN9,Q8IYU8,Q8IWA4,Q9NX14,O60488,Q15154,Q9NVA1,O75323,P62995,Q13153,Q96IX5,O95619,P12236,Q9P0J0,P57105,Q5JVF3,Q96S66,Q8N2G8,P52789,Q9Y320 141 +Intrinsic component of mitochondrial membrane 0.5917044693696517 3.3192337378188976 0.0009026484043046 0.549907218534967 0.0132990198234218 44 Q99595,Q9Y2R0,Q8TB36,Q15070,Q6P4A7,O60830,Q9BWH2,O14925,O96008,Q6UXV4,Q9H3K2,Q13505,Q96AQ8,O75431 14 +Intrinsic component of mitochondrial inner membrane 0.6799479248853804 3.2586987729129846 0.0011192443846197 0.6284107295681696 0.0159582586452234 28 Q99595,Q9Y2R0,Q15070,Q6P4A7,O60830,O14925,Q6UXV4,Q13505,Q96AQ8,O75431 10 +Membrane protein complex 0.3852284286706998 3.1950542484495763 0.0013980455935984 0.7096699830926504 0.0184458552946424 253 Q99595,Q8NEB9,Q15005,Q9Y277,O60830,P13073,P21796,P14406,Q9H9C1,P21912,Q9NS69,O75306,Q9UBU6,P25054,P62993,P45880,P35606,P41440,Q9Y6M9,O96000,P67812,Q8IYU8,P01889,Q13505,Q9Y679,Q9Y487,Q8IWA4,Q13546,Q93050,Q9BUN8,Q8TCT9,Q9NX14,O14949,O95168,Q9NR31,O75431,Q8N511,Q13190,Q9UDW1,O15400,Q86Y39,Q96IX5,O75964,O95487,P12236,Q8N4H5,Q9P0J0,P62942,Q53GQ0,Q9Y5M8,P08195,O43676,Q9P2W9,O14925,Q07666,O96008,Q6UXV4,O15269,P62072,P46977,Q15257,P51809,Q9H267,Q9UEU0 64 +Inner mitochondrial membrane protein complex 0.5008694365458507 3.1105673778152676 0.0018672829016685 0.8083761892126264 0.0226120285626718 71 Q99595,O60830,P13073,O95168,P14406,P21912,O75306,O96000,Q9Y6M9,Q8IYU8,Q13505,Q9NX14,O14949,O75431,Q9UDW1,Q86Y39,Q96IX5,O75964,P12236,O43676,O14925,Q6UXV4,P62072 23 +Golgi membrane 0.444689680738198 3.065766175998186 0.0021711303112468 0.8535931250304951 0.0258368649510842 105 Q9HC07,P24390,Q99640,Q8NCH0,Q9Y3E0,P35606,P51790,Q8IV08,O00461,P01889,P11166,Q14108,Q15392,Q92896,Q10713,Q13190,Q9UM00,Q9Y282,Q96L58,O95197,Q7LGA3,P50570,P22059,Q8IZA0,Q8TB61,Q9H4A6,Q9NTJ5,P61006,Q9P2W9,O15027,Q96S66,O15258,P51572,Q9H7Z7 34 +Coated vesicle 0.4623124006359041 2.8522246280389125 0.0043414409687958 0.9786390090174384 0.0426425979601725 78 P24390,P35606,P01889,Q5VW38,Q14108,P42892,P05067,Q8N511,Q13190,Q9Y282,P53634,O95487,Q99523,P61006,O15126,P51809,Q96RQ1,P51572,Q9H267,Q9UEU0 20 +Microbody membrane 0.6254600250180784 2.8199673318453744 0.0048028538741724 0.9858204058829994 0.0446918192080889 27 Q8TB36,P28288,Q15067,Q8NBU5,O60488,Q96HA9,Q9BY49,Q9NR77,P36507,P50542,O75381,P51648 12 +Signal peptidase complex 0.8594436310395364 2.7924919227184044 0.0052303773423791 0.9903015347346013 0.0467035714208404 2 P67812 1 +Histone pre mrna 3 end processing complex 0.8535871156661841 2.765215590301098 0.0056885186064756 0.9935456935708276 0.0484166400795565 2 O60506 1 +Vacuolar proton transporting v type atpase v0 domain 0.9565807711272718 2.746235262508373 0.0060283517194326 0.9952289577676684 0.0485963155907416 3 Q9Y487 1 +Proton transporting v type atpase v0 domain 0.9565807711272718 2.746235262508373 0.0060283517194326 0.9952289577676684 0.0485963155907416 3 Q9Y487 1 +Haus complex 0.83089311859444 2.658699117543775 0.0078442982440403 0.999052515815608 0.0587657597265393 2 O94927 1 +Integral component of cytoplasmic side of endoplasmic reticulum membrane 0.8206442166910757 2.610164453354273 0.0090498705466353 0.9996765627155598 0.0655744718297181 2 Q8TCT9 1 +Gamma tubulin complex 0.8111273792093757 2.564855321067748 0.0103218834425529 0.9998960876481028 0.0729963597057342 2 Q9BSJ2 1 +Equatorial microtubule organizing center 0.8111273792093757 2.564855321067748 0.0103218834425529 0.9998960876481028 0.0729963597057342 2 Q9BSJ2 1 +Mitochondrial protein containing complex 0.3954544966173465 2.5148909577098912 0.0119069204268258 0.9999748054790693 0.0809670589024157 136 Q99595,O60830,P13073,P21796,O95168,P14406,P21912,Q9NS69,O75306,Q9BYC9,O96000,Q9Y6M9,Q8IYU8,Q13505,Q8IWA4,Q567V2,Q9NX14,O14949,P82933,O75431,Q9UDW1,Q86Y39,Q9HCC0,Q96IX5,O75964,P12236,Q8N4H5,Q9NYK5,P40939,O43676,O14925,O96008,Q6UXV4,P62072 34 +Endoplasmic reticulum golgi intermediate compartment membrane 0.6214404776890855 2.4954425359849366 0.0125800129357969 0.9999862059489584 0.0829905330988393 21 Q9Y282,P53634,P24390,Q96RQ1,P51572,Q8N511,Q13190 7 +Outer mitochondrial membrane protein complex 0.6771431359137625 2.418336547814107 0.0155916486821059 0.9999990732643924 0.0987601054111472 15 O96008,Q9NS69,Q8N4H5,Q6UXV4,Q13505,O75431 6 +Microbody 0.4724000813317116 2.3358514725820063 0.0194989838731696 0.9999999724529878 0.1172952705439095 49 Q8NEB9,Q8TB36,P28288,Q15067,Q8NBU5,O15254,O60488,Q96HA9,Q8N4Q0,O75381,Q13011,Q9BY49,O14734,Q9NR77,P36507,P08670,P51648 17 +Cis golgi network 0.7999195648424127 2.3266556378485865 0.0199836007420741 0.9999999822059302 0.1192979773793 10 Q9NPR9,O00461 2 +Neurofilament 0.8546320029293298 2.311240872980924 0.0208195538894266 0.999999991631353 0.1218840108493588 3 Q16352,P07197 2 +External side of plasma membrane 0.6134208789969493 2.2966857769675175 0.0216367013977909 0.99999999599931 0.125834500234521 18 P41440,P42892,P51790,Q4VCS5,O96005,P08183 6 +Nuclear inner membrane 0.5960891963972225 2.226138285584941 0.0260049201797942 0.9999999999234088 0.1442686854705363 19 Q99720,Q14739,O75844,Q5SNT2,Q9H1E5,P43243,P50402 7 +Proton transporting two sector atpase complex 0.5850522216954098 2.1977325732644237 0.0279681688793727 0.9999999999871308 0.151680130609604 20 Q93050,Q8N511,Q9Y487 3 +Copii coated er to golgi transport vesicle 0.5169553391430619 2.136533129687397 0.0326359835785807 0.9999999999998174 0.1707112987187302 30 Q9Y282,P53634,O95487,O15027,P01889,Q96RQ1,Q13190,P05067,Q9UEU0 9 +Endocytic vesicle membrane 0.4842206846291975 2.133012715399116 0.0329236831342312 0.9999999999998596 0.1712031522980023 36 Q93050,Q8WTV0,Q8NEB9,P61006,Q14108,P01889,P51809,Q9Y487,Q13555 9 +Proton transporting two sector atpase complex proton transporting domain 0.8127666268658664 2.129773710585575 0.0331903001116968 0.99999999999989 0.1715802649049125 8 Q93050,Q9Y487 2 +Mitochondria associated endoplasmic reticulum membrane 0.7813059415478013 2.1063316975525943 0.0351755497697396 0.999999999999982 0.1756096887172173 9 Q96N66,O60488,O96008,Q96S66,O43865,P51572 6 +Respirasome 0.4647785429892009 2.097322522823033 0.0359650343925395 0.9999999999999912 0.1756096887172173 42 Q86Y39,Q96CU9,P13073,O95168,P14406,P21912,Q9NX14,O14949,O75306,Q9P0J0,Q13423,O96000,Q9Y6M9,Q7KZN9,O43676,Q9UDW1 16 +Organelle membrane contact site 0.6230222729977728 2.095130681282035 0.0361593772098203 0.9999999999999928 0.1756096887172173 15 Q96N66,O60488,O96008,Q96S66,O95772,O43865,Q9NTJ5,P51572 8 +Recycling endosome 0.4869999605247033 2.085332452425208 0.0370391336020645 0.9999999999999968 0.1756096887172173 34 O15400,O14773,P61006,Q9H9C1,O15126,Q96A57,P51790,O15127,P01889,Q86Y82,Q9H267,P05067,Q9UEU0 13 +Vacuole 0.3483686163508591 2.082267792064212 0.0373180160921811 0.9999999999999974 0.1756096887172173 195 Q9HC07,Q8NEB9,Q9UEU0,P50897,Q8TBX8,Q96A57,O15118,P41440,P08236,P46976,Q8IV08,O95772,P51790,Q9Y679,Q9Y487,Q9NX40,Q93050,Q8WTV0,O14773,Q14108,Q99536,Q9BWS9,Q15165,Q9UIQ6,Q969Q5,P42892,P54802,P00813,Q8N511,Q07065,O75503,P38435,Q8NHP8,P53634,O15400,Q9BTY2,Q96GC9,Q16625,Q8NCG7,P27105,P04062,P42785,Q99523,Q8NCC3,Q9H0B6,Q5BJF2,Q9NZJ7,Q01085,Q9Y6I9,Q9UHG3,P07602,O43681,P51809,Q9H267,Q9H7Z7 55 +Lipid droplet 0.5161132114409627 2.081951972002257 0.0373468568765122 0.9999999999999976 0.1756096887172173 29 Q99720,O43760,Q8N0X7,Q8NBX0,P48449,Q01105,Q07065,P60604 8 +Golgi lumen 0.8889047258967835 2.063235602426453 0.0390902490927365 0.9999999999999996 0.1759340697741742 4 P05067,O00461 2 +Hrd1p ubiquitin ligase erad l complex 0.7934822409373856 2.0401291868279516 0.0413374603967904 1.0 0.1782178647171831 3 Q9BUN8,Q9Y679 2 +Endoplasmic reticulum golgi intermediate compartment 0.4587174970713348 2.0390715323743644 0.0414428888903399 1.0 0.1782178647171831 42 Q9Y282,P53634,P80303,P24390,Q96RQ1,Q02818,P51572,Q8N511,Q13190 9 +Cortical endoplasmic reticulum 0.7038799414348536 2.0381952796773293 0.0415304073888458 1.0 0.1782178647171831 2 P50402 1 +Endosome 0.3459553263207118 2.02040137395214 0.0433417710320185 1.0 0.183321175082796 188 Q9HC07,Q8NEB9,P14373,Q9H9C1,Q96A57,O15118,P62993,P41440,P51790,Q8IV08,O00461,O95772,P01889,Q5VW38,Q9Y487,Q9NX40,Q13546,Q93050,Q9BUN8,O14773,Q14108,Q9BWS9,Q9UIQ6,Q969Q5,P42892,O15127,P36507,P05067,Q9ULJ7,O15400,Q9BRK5,Q9H4A6,Q96J02,P31751,Q9BZF3,Q7Z6M1,Q99523,P61006,Q9NZJ7,O15126,P07602,P51809,Q9H267,Q9UEU0 44 +Proton transporting v type atpase complex 0.7063495320052886 1.99629650666358 0.0459016580754112 1.0 0.1894744593999243 11 Q93050,Q9Y487 2 +Core mediator complex 0.6914348462664706 1.9752169000140187 0.0482435388565982 1.0 0.1961285835166218 2 Q15648 1 +Rough endoplasmic reticulum 0.479742235845613 1.9721856601390544 0.0485884160521947 1.0 0.1961285835166218 33 Q96A33,Q8TCT9,Q9UQB8,Q5BJF2,Q9Y5M8,P14618,P05067,Q07065 8 +Perinuclear endoplasmic reticulum 0.864080413926336 1.9623560316250228 0.0497210479686238 1.0 0.1974805861527354 4 P22059,Q9BZF3 2 +H3 histone acetyltransferase complex 0.6786237188872646 1.910006503125568 0.0561323760126752 1.0 0.2100279273991852 2 O95251 1 +Phagocytic vesicle membrane 0.5300985972463576 1.9068039438825848 0.0565459804536268 1.0 0.2100279273991852 22 Q93050,Q8NEB9,P61006,P51809,P01889,Q9BZG1,Q9Y487 7 +Hops complex 0.8485155228071223 1.8986129698633536 0.0576153818562192 1.0 0.2126778970330322 4 Q9H9C1 1 +Tim23 mitochondrial import inner membrane translocase complex 0.7864010147892211 1.8966131519351577 0.057879013498866 1.0 0.2126778970330322 7 Q99595,O14925,P62072,O60830 4 +Vacuolar membrane 0.3588034631108369 1.8668794521839505 0.0619184239141266 1.0 0.22269729182874 110 Q9HC07,O15118,P41440,Q8IV08,O95772,Q9Y487,Q93050,Q8WTV0,Q14108,Q9UIQ6,P42892,Q8N511,Q07065,O75503,Q96GC9,Q8NCG7,P04062,P42785,Q99523,Q9NZJ7,Q9Y6I9,P07602,P51809,Q9H267,Q9UEU0 25 +Proteasome core complex beta subunit complex 0.7762998158421044 1.8511695492506948 0.0641451650197588 1.0 0.2268173035098673 7 Q99436,P28070,P28072,P49721 4 +Plasma membrane raft 0.5668624324912468 1.844745619426262 0.0650745513557475 1.0 0.2291868661294058 16 Q8WTV0,P09601,P41440 3 +Platelet alpha granule 0.5486359159059933 1.8302660546429288 0.0672101647006369 1.0 0.2348370972148736 17 Q9Y6I9,Q8NBX0,P05067,P51809,Q9H267,Q9UEU0 6 +Golgi apparatus subcompartment 0.3997730618669931 1.793005727789515 0.07297200821196 1.0 0.2490627616191995 65 Q9HC07,Q96A57,O00461,Q9NPR9,Q9BWS9,Q10713,O15127,P05067,Q96L58,P22059,Q9H4A6,P04062,Q7Z6M1,Q99523,P61006,O15126,Q9BZG1,P51809,P51572 19 +Caveola 0.6352663200298783 1.7854325422440962 0.0741911841160036 1.0 0.2522500259944125 12 Q8WTV0,P09601,P41440 3 +Early endosome 0.3668281514953203 1.7406536251078708 0.0817443117740135 1.0 0.2714681343762777 87 Q9HC07,P14373,Q9H9C1,Q96A57,P41440,P51790,Q8IV08,P01889,Q5VW38,Q9BUN8,Q9UIQ6,P36507,P05067,Q96J02,P31751,Q9BZF3,Q99523,Q9H267,Q9UEU0 19 +Late endosome 0.4022501816953154 1.7392363188725064 0.0819932034824277 1.0 0.2714681343762777 61 Q9HC07,Q9BUN8,Q8NEB9,Q14108,Q9H9C1,Q9NZJ7,Q96A57,O15118,Q9BRK5,O95772,P07602,P51809,Q9H267,Q9UEU0 14 +Endoplasmic reticulum lumen 0.4113937450821845 1.7123142576404693 0.0868387705788023 1.0 0.280463706901369 51 P13674,Q32P28,P53634,O43852,Q9BTY2,Q14257,Q8TED1,Q9NWM8,Q02818,O76024,Q9Y680,P05067,O43681,Q07065 14 +Sperm annulus 0.6390922401171331 1.7065211127334134 0.0879110988403346 1.0 0.2815703310683182 2 Q15019 1 +Acrosomal membrane 0.6383601756954634 1.7027230508581357 0.0886199090155299 1.0 0.2817985596033399 2 P35613 1 +Endocytic vesicle 0.3699049002746161 1.689847058648719 0.0910572181840381 1.0 0.2885110425616118 76 Q8NEB9,P51790,O00461,P01889,Q9Y487,Q93050,Q8WTV0,Q14108,Q969Q5,P08670,O15400,Q16625,P50570,Q4VCS5,Q13555,P61006,P51809,Q9BZG1,Q86Y82 19 +Er ubiquitin ligase complex 0.7937728937728944 1.6716305195440375 0.0945972027377293 1.0 0.2946524214500816 4 Q9BUN8,Q9Y679,Q9UBU6 3 +Proteasome core complex 0.5520208722018128 1.6534377569367762 0.0982418039380794 1.0 0.3004433450452572 15 Q99436,P28070,P28072,P49721 4 +Platelet alpha granule lumen 0.5815264058160354 1.6502152299869293 0.098898922926526 1.0 0.3004433450452572 13 P05067,Q8NBX0,Q9UEU0,Q9Y6I9 4 +Messenger ribonucleoprotein complex 0.7905746189503311 1.6502021420531237 0.0989015988780201 1.0 0.3004433450452572 5 Q9NUL3,Q99729,P51991 3 +Clathrin coated vesicle 0.4221466731599392 1.6143259120658615 0.1064567524646917 1.0 0.3136925639292917 39 Q99523,P61006,Q14108,P51809,P42892,Q5VW38,P51572,Q9H267 8 +Trans golgi network 0.4030200688561068 1.6026894844849446 0.1090032262714755 1.0 0.3190690464370342 48 Q9HC07,Q7Z6M1,P61006,Q9BWS9,P51809,O15126,Q96A57,P22059,Q9H4A6,O15127,P05067,P04062,Q9NPR9 13 +Snare complex 0.5716173692814718 1.5913793713661144 0.111524223934506 1.0 0.3243007038095503 13 O15400,Q9P2W9,Q86Y82,P51809,Q13190,Q9UEU0 6 +Golgi cisterna 0.5535156148278184 1.5766909444803014 0.1148666550468668 1.0 0.3318370034687266 14 Q99523,Q96L58,Q9H4A6,Q10713,O00461,P51572 6 +Integral component of synaptic vesicle membrane 0.7711264000200335 1.5682997906451708 0.1168111847766106 1.0 0.3352632705926099 5 O76024,O15126,Q86Y82 3 +Derlin 1 retrotranslocation complex 0.7629699295533148 1.5422288038323155 0.1230180029327665 1.0 0.3462245791392289 4 Q9BUN8 1 +Pore complex 0.6642701506682944 1.5368196289049718 0.1243374852605465 1.0 0.3462245791392289 9 P21796,P45880,Q9Y277 3 +Postsynaptic density membrane 0.7631146002885627 1.5344357296407662 0.1249224932805956 1.0 0.3462245791392289 5 Q99720 1 +Integral component of presynaptic active zone membrane 0.6057833089311897 1.532779617249737 0.125330164394291 1.0 0.3462245791392289 2 P20020 1 +Presynaptic active zone membrane 0.6057833089311897 1.532779617249737 0.125330164394291 1.0 0.3462245791392289 2 P20020 1 +Intrinsic component of presynaptic active zone membrane 0.6057833089311897 1.532779617249737 0.125330164394291 1.0 0.3462245791392289 2 P20020 1 +Respiratory chain complex iii 0.7031858252074497 1.517027514382158 0.1292597374333599 1.0 0.3507777586016388 7 O14949 1 +External encapsulating structure 0.4430783449250554 1.5147786254870792 0.1298284751716445 1.0 0.3509736148371063 30 Q32P28,P53634,Q9NZJ7,Q92896,P14618,P07602,O14936,P84157 8 +Phagocytic vesicle 0.4135160646760776 1.511727961932827 0.1306030821583546 1.0 0.3511179676369034 38 Q93050,Q8NEB9,P61006,P50570,Q9BZG1,P51790,P01889,P51809,Q9Y487,P08670 10 +Dendrite cytoplasm 0.6051421879111162 1.4577337831171453 0.1449139362710814 1.0 0.37813009254111 11 Q9UQB8,Q9NUL3 2 +Micos complex 0.7413919413919421 1.4510082527075083 0.1467775621995672 1.0 0.3782838629283308 4 Q6UXV4,Q16891,Q9NX63 3 +Dendritic shaft 0.7427547621098255 1.448094857255806 0.1475905236430077 1.0 0.3792733223849385 5 Q9UQB8,Q14168,P05067 3 +Endosome lumen 0.7389662116225375 1.4407292275651085 0.1496611943603936 1.0 0.3834796980132984 4 Q9UIQ6 1 +Vesicle membrane 0.3111250573800598 1.4339564210294695 0.1515846993614442 1.0 0.384197192073376 213 Q9HC07,O00264,Q8NEB9,P24390,O15118,P62993,P35606,O43924,Q8IV08,O00461,O95772,P01889,Q9Y487,Q13546,Q93050,Q8WTV0,Q14108,Q9UIQ6,O76024,P42892,Q8N511,Q07065,Q13190,O95487,Q5T9A4,Q96J02,P30519,O43760,Q13555,Q9BZF3,P42785,Q7Z6M1,Q99523,P61006,Q9NZJ7,O15126,O15027,P07602,P51809,Q9H267,Q9UEU0 41 +Nadh dehydrogenase complex 0.4623165502643481 1.433623755389158 0.1516796606715025 1.0 0.384197192073376 23 Q86Y39,Q96CU9,O95168,Q9NX14,O75306,Q9P0J0,O96000,Q9Y6M9,O43676 9 +Oxidoreductase complex 0.3832846829053773 1.4121492722435007 0.1579060133617604 1.0 0.3943189712197634 53 P13674,Q86Y39,Q96CU9,O95168,Q9NX14,P43304,P21912,O14949,O75306,Q9P0J0,O96000,Q9Y6M9,O43169,P31350,O43676,Q9UDW1 16 +Golgi cisterna membrane 0.5938499038099624 1.396241729181554 0.1626417145136418 1.0 0.4027318645099703 11 Q96L58,Q9H4A6,Q10713,O00461,P51572 5 +Azurophil granule membrane 0.4714654042930712 1.390925782016662 0.1642479337493343 1.0 0.4033916465463457 20 P42785,Q9NZJ7,Q07065,P07602 4 +Cell surface 0.3653065062344538 1.381310031633845 0.1671836550750707 1.0 0.4071359534059574 65 Q8WTV0,O75298,Q99523,Q4VCS5,Q8TCT9,P41440,O43847,P42892,P08195,P51790,P01889,P00813,O96005,P08183,P05067 15 +Membrane microdomain 0.3799589476729368 1.3752551893231764 0.1690523436318312 1.0 0.4075633124273844 53 Q8WTV0,P50897,P21796,O15118,P41440,P09601,P05067,Q13546 8 +Sorting endosome 0.5754026354319244 1.373018931660664 0.1697464613461159 1.0 0.4077605212770828 2 P18031 1 +Presynaptic active zone 0.5348897905488255 1.371007755379582 0.1703725384502292 1.0 0.407800589777273 13 P05067,Q13363 2 +Mcrd mediated mrna stability complex 0.7196991560765114 1.3589462170555489 0.1741636320723478 1.0 0.4117274181115146 4 O60506 1 +Specific granule membrane 0.5318460597988994 1.352603692846898 0.1761822720723009 1.0 0.4122066629709337 13 P30519,O00264,Q07065,O15126 4 +Sarcoplasmic reticulum membrane 0.6259077498858293 1.3445857734458084 0.1787590401359198 1.0 0.4147585078219241 9 P62942,P16615,Q13555 3 +Golgi associated vesicle 0.4389241708265132 1.3395042964327657 0.1804065566997483 1.0 0.4150448715697294 26 P61006,P24390,P35606,P05067,Q8N511 5 +Lysosomal lumen 0.4083468922287218 1.3298801062822043 0.1835577769640324 1.0 0.4203758415445716 33 Q8NHP8,O14773,P50897,Q14108,Q9NZJ7,P46976,P08236,Q8IV08,P54802,P07602,O43681,P04062,P38435 13 +Collagen containing extracellular matrix 0.4350890778253373 1.3080332926616722 0.1908620173154784 1.0 0.4296200376860972 26 Q32P28,Q9NZJ7,P14618,P07602,O14936,P84157 6 +Intrinsic component of golgi membrane 0.6725041648805337 1.285458825830774 0.1986319960593219 1.0 0.437082157010164 6 Q9Y282 1 +Neuromuscular junction 0.4947292561657442 1.2842511279330764 0.1990541009307396 1.0 0.437082157010164 15 Q14168,P07196,P57105,P05067,O43760 5 +Sarcoplasm 0.4821563389913573 1.283668295626568 0.1992580421663983 1.0 0.437082157010164 16 O75298,O43852,P62942,P16615,Q13555 5 +Postsynaptic specialization membrane 0.6324735934869111 1.2782405269357804 0.2011646305514776 1.0 0.4391855858936804 8 Q99720 1 +Pericentriolar material 0.6262788337340994 1.266319080432581 0.2053988684840226 1.0 0.4432317942945184 3 Q15154 1 +Mib complex 0.6100123682396478 1.2644384465423506 0.2060727007410034 1.0 0.4432317942945184 9 Q13505 1 +Endoplasmic reticulum tubular network 0.5877695386260402 1.2524150669886345 0.2104186589342025 1.0 0.4492997451638527 10 Q9NQC3,Q00765,P50402 3 +Crd mediated mrna stability complex 0.6643058199010816 1.248521358268451 0.2118401917397629 1.0 0.4509133492692416 6 O60506 1 +Exocytic vesicle 0.393765502246758 1.234371788579008 0.2170643964493486 1.0 0.4590548479933592 34 O00429,O15400,P61006,P50897,Q92905,O15126,Q96A57,O76024,P51790,P05067,O43760,Q86Y82,Q9UEU0 13 +Intrinsic component of plasma membrane 0.3578464457897429 1.2215188616315429 0.2218896285897751 1.0 0.4648114494629412 61 P36551,O00264,Q8WTV0,O60637,P30825,O15118,Q9UIQ6,P41440,P51572,P01889,O96005,Q02978,P16615,P05067,O43657 15 +Cytochrome complex 0.4720596201785121 1.2153559260537092 0.2242303701652663 1.0 0.466399169943754 16 P14406,O14949,P13073,Q9UDW1 4 +Apical plasma membrane 0.3855317360961585 1.209877270264404 0.2263259902769199 1.0 0.4696529939079746 36 P36551,P11166,Q99797,Q16625,P30825,P41440,P51790,Q86UE4,O43865,P08183 10 +Mitochondrion 0.2981061406157776 1.19808976054676 0.2308820746738717 1.0 0.4760773612259092 547 Q99595,O60830,P21796,Q9NS69,O75306,P23786,P45880,Q9H2D1,Q9H773,O43169,Q13505,Q96AQ8,Q70HW3,Q15165,O14949,Q9H061,P00367,Q9NZ45,Q3SXM5,Q9NPH0,O75431,Q96EY8,Q9UDW1,Q15070,Q9HCL2,O75964,Q8N4H5,Q9UBX3,O43847,P28070,Q69YU5,Q9NUJ1,O43676,Q9UDX5,Q9NZJ7,O43772,Q13011,P62072,Q8WY22,Q8WWV3,Q9H7Z7,Q9Y2R0,Q9BY49,Q9NR77,Q02978,Q567V2,Q9H0R6,P16435,Q8NBX0,P09601,Q9BWD1,Q9NQZ5,Q86Y39,Q5T9A4,Q96A26,Q9BUK6,Q5JRX3,Q7L592,Q8N0X7,Q9H6K4,P14618,Q16836,P51572,P36551,O00264,Q6YP21,Q9Y277,P13073,O95168,P14406,P21912,O96000,Q9Y6M9,Q9BSK2,Q13546,O43823,P23396,Q99536,P82933,Q10713,Q8WWC4,O95202,Q6P4A7,Q8NBU5,P43304,Q15120,Q9NYK5,Q9H4A6,P40939,O43615,O60313,Q9BWH2,Q9NVI7,Q9H0B6,Q13423,O14925,O96008,Q6UXV4,Q9H3K2,Q8N2A8,Q13057,Q8TB36,Q9H845,Q9BYC9,O75027,Q7KZN9,Q8IYU8,Q96EK5,Q8IWA4,Q9NQP4,P28288,Q9NX14,O60488,Q9NVA1,P36507,O75323,Q9HCC0,Q96IX5,Q99797,P12236,Q9P0J0,Q5JTZ9,P57105,P50542,P27105 125 +Transport vesicle 0.3299334804548983 1.1925394805234064 0.2330497797901052 1.0 0.4774183260386047 82 P50897,P24390,Q96A57,P35606,P51790,O00461,P01889,O15260,Q9NR31,O76024,P05067,Q13190,O00429,O15400,Q7L0J3,O95487,O43760,Q7Z6M1,Q99523,P61006,Q92905,O15126,O15027,P51809,Q86Y82,Q9UEU0 26 +Apical part of cell 0.3623680027742031 1.176718325249293 0.2393079511100153 1.0 0.481966039858575 49 P36551,P11166,Q86UE4,Q99797,Q16625,Q15154,P30825,P41440,Q13325,P51790,P05067,O43865,P08183 13 +Tor complex 0.5369692532942906 1.1702650526478464 0.2418943210159347 1.0 0.4826965683478247 2 P42345 1 +Torc1 complex 0.5369692532942906 1.1702650526478464 0.2418943210159347 1.0 0.4826965683478247 2 P42345 1 +Intrinsic component of presynaptic membrane 0.6010874065894962 1.1476838821300044 0.2510990873261982 1.0 0.4954723062418733 3 P20020 1 +Autophagosome 0.4065624898088157 1.1286787768691664 0.2590333653637797 1.0 0.5054867438887005 28 Q8NEB9,Q96GC9,Q8TBX8,Q96A57,Q9Y6I9,Q9Y679 6 +Photoreceptor inner segment 0.6635070611784617 1.1198519533430926 0.2627768556656713 1.0 0.5105378910075901 4 P11166 1 +Prefoldin complex 0.6606815683400481 1.0978580940263971 0.2722664591997024 1.0 0.5198644756140969 5 O15212,P61758,Q9UHV9,Q9NQP4 4 +Mrna editing complex 0.5186676427525716 1.073995919653855 0.2828245103406761 1.0 0.531665300926425 2 Q15007 1 +Ciliary basal body 0.4722774514125375 1.0666019322289928 0.2861516276068641 1.0 0.531665300926425 14 A0AVF1,P48729,P61006,P28070 4 +Sin3 complex 0.5172035139092336 1.0663149007686166 0.2862813158834518 1.0 0.531665300926425 2 Q9UBU8 1 +Esc e z complex 0.5172035139092301 1.0663149007685997 0.2862813158834596 1.0 0.531665300926425 2 Q15022 1 +Transporter complex 0.3506474367265787 1.0467128662097394 0.2952320278614968 1.0 0.5326226788358432 50 Q9C0H2,Q96CU9,O95168,O75306,O96000,Q9Y6M9,Q8IYU8,O43674,Q9NX14,O14949,Q9UDW1,Q86Y39,Q9P0J0,P62942,O43676,Q96S66,P62072,Q15257,O75381 19 +Copi coated vesicle 0.4804417837101134 1.039871422955687 0.2983996407804827 1.0 0.5372409011200545 13 Q8N511,P24390 2 +Gemini of coiled bodies 0.6401604283322719 1.0104942560107224 0.3122585500073547 1.0 0.5565253189647209 5 O75312 1 +Endoplasmic reticulum exit site 0.4265837034739615 1.0055061671566532 0.3146531813520532 1.0 0.5585409885847692 18 Q96PC5,O95487,O15027,Q9HCU5 4 +Female pronucleus 0.6338287336190683 0.9941045054847902 0.3201719921141528 1.0 0.5626879543318312 4 P11166 1 +Ciliary base 0.6067792822985373 0.9896273410976568 0.3223563011016317 1.0 0.5654027185988938 6 P61006 1 +Golgi stack 0.4125509348246399 0.9826881134510148 0.3257609626589852 1.0 0.5679934733541282 21 Q99523,Q96L58,Q9H4A6,Q10713,O00461,P51572 6 +Intrinsic component of mitochondrial outer membrane 0.4698040533024763 0.9750302998978958 0.3295452302985664 1.0 0.5703318867515895 13 Q9BWH2,O96008,Q8TB36,Q8IWA4 4 +Side of membrane 0.3389142171208245 0.9573542738920324 0.3383884698339192 1.0 0.5769414260496996 58 Q8TCT9,P62942,P41440,P42892,P51790,P36507,P01889,Q4VCS5,O96005,P51572,P08183 11 +Ciliary plasm 0.4879816632474307 0.9436172298801832 0.3453652842967927 1.0 0.5788380041149233 12 Q8NEB9 1 +Copi coated vesicle membrane 0.4860612928199159 0.9325456507910292 0.3510546059429948 1.0 0.5812525124553989 12 Q8N511,P24390 2 +Er to golgi transport vesicle membrane 0.399080523159705 0.9108442916495042 0.3623774216161375 1.0 0.5885482681846824 22 O95487,O15027,P01889,Q13190,Q9UEU0 5 +Trans golgi network membrane 0.3930846335168251 0.8895060178387165 0.3737311904734341 1.0 0.5952763466279564 23 Q9HC07,Q7Z6M1,P61006,O15126,P05067 5 +Cytoplasmic ubiquitin ligase complex 0.5814200394288699 0.8765750461808459 0.3807174979581995 1.0 0.6020648804920365 6 Q9BUN8,Q9Y679,Q9UBU6 3 +Coated vesicle membrane 0.3353646129963172 0.8749533215211558 0.38159930445067 1.0 0.6023817591685577 52 Q14108,P24390,O95487,P35606,P01889,P51809,Q8N511,Q13190,Q9UEU0 9 +Tight junction 0.3891758389471683 0.8586951235452641 0.3905087415672157 1.0 0.6069738725048556 23 Q16625,P25054,Q68EM7,Q9NR77,Q86UE4,Q4VCS5 6 +Presynapse 0.3063996426124242 0.856966193025792 0.3914635685887615 1.0 0.6069738725048556 80 P11166,O15400,P61006,P50897,Q9UQB8,P50570,Q92905,O15126,Q96A57,P07196,Q13363,P41440,O76024,P51790,P05067,O14936,O43760,Q9UEU0 18 +Transport vesicle membrane 0.3451173688130149 0.8508680369315588 0.3948426620065852 1.0 0.6070276751544719 39 O00429,Q7L0J3,O95487,O15126,Q9NR31,O15027,Q86Y82,O76024,P01889,P51809,O43760,Q13190,Q9UEU0 13 +Main axon 0.5244263407860494 0.8333491194710714 0.4046478613864399 1.0 0.6147277021034803 9 Q14168 1 +Lumenal side of endoplasmic reticulum membrane 0.5397623125413609 0.8297024043210556 0.4067070617481549 1.0 0.6147277021034803 8 P01889,P51572,Q8TCT9 3 +Mitotic spindle microtubule 0.5941909805451235 0.82830023409526 0.4075004903084156 1.0 0.6147277021034803 4 O94927 1 +Presynaptic endocytic zone 0.4677891654465717 0.8106145928689158 0.4175870339236192 1.0 0.6235590168724314 2 P09496 1 +Paraspeckles 0.565333901647513 0.8056070398768743 0.4204694651392118 1.0 0.625241158190641 6 P23246,Q15233,P52272 3 +Cop9 signalosome 0.485359442553273 0.8019173478977952 0.4226007704084056 1.0 0.6268105386594471 11 P62993,Q9H9Q2,Q92905,Q7L5N1 4 +Phagophore assembly site 0.5160250906955227 0.7916580905428829 0.4285600652915557 1.0 0.6306573495176309 9 Q8NEB9,Q96GC9 2 +Chromocenter 0.5228853899670451 0.7849843875127468 0.4324627224339687 1.0 0.6312764044629536 3 Q06787,P45973 2 +Golgi associated vesicle membrane 0.4081790042700549 0.782070045300413 0.4341734096995895 1.0 0.6312764044629536 16 Q8N511,P24390 2 +Beta catenin destruction complex 0.5588080117761347 0.7770354365118315 0.4371378635595804 1.0 0.632454781320244 6 P48729,P25054 2 +Endoplasmic reticulum protein containing complex 0.3263777107813529 0.7742670162947631 0.4387729046673319 1.0 0.6337830845194794 52 Q15005,Q9BUN8,Q8TCT9,Q9UBU6,P62942,Q53GQ0,O15269,P46977,Q9Y5M8,P67812,Q6NUQ1,O43681 12 +Postsynaptic specialization intracellular component 0.570117611634281 0.7296838884289855 0.4655834316161589 1.0 0.6627628881621328 4 Q9UQB8 1 +Postsynaptic density intracellular component 0.570117611634281 0.7296838884289855 0.4655834316161589 1.0 0.6627628881621328 4 Q9UQB8 1 +Cilium 0.2977158439353803 0.7275991840674525 0.4668589802286953 1.0 0.6635101905501071 77 Q8NEB9,A6NIH7,P61006,O43924,P28070,P14618,P05067,O14936 8 +Rough endoplasmic reticulum membrane 0.4084401002597104 0.7207253425923704 0.4710785169311255 1.0 0.6652290878068929 15 Q5BJF2,Q96A33 2 +Endosome membrane 0.2836363375394874 0.7004350150501124 0.4836556754928089 1.0 0.676113722935966 110 Q9HC07,O15118,Q8IV08,O00461,P01889,O95772,Q9Y487,Q13546,Q93050,Q14108,P42892,Q96J02,Q9BZF3,Q7Z6M1,Q99523,P61006,P51809,Q9H267,Q9UEU0 19 +Nucleoid 0.3553555528600036 0.6916960883554292 0.489128203998068 1.0 0.6809280824162081 28 P21796 1 +Transcription preinitiation complex 0.5597231750367089 0.6877900658884729 0.4915849928247282 1.0 0.683272222731226 4 P29083 1 +Origin recognition complex 0.4997326772509335 0.6815777362080458 0.4955059968362418 1.0 0.6847726429423696 3 Q9Y619 1 +Secretory granule membrane 0.3124904946448134 0.6810799116394839 0.4958209273117102 1.0 0.6847726429423696 61 Q93050,O00264,P42785,Q9NZJ7,Q5T9A4,P30519,P51809,Q07065,P07602 9 +Vesicle tethering complex 0.3921030822827929 0.6744973772837969 0.4999951525928812 1.0 0.6873961351354696 16 Q9H9C1,Q9H267 2 +Pronucleus 0.5532580000918295 0.649855100018332 0.5157858233972645 1.0 0.6961139967682165 5 P11166 1 +Nuclear outer membrane 0.4717977208610706 0.6479678776350166 0.5170057267187425 1.0 0.6966967414929395 10 Q99720,Q9UBM7 2 +Perinuclear region of cytoplasm 0.2744449557632432 0.6434090987314406 0.5199586810395935 1.0 0.6996095495266372 161 O75935,O15118,P25054,Q7L5N1,Q9Y487,Q93050,O95684,Q9UIQ6,P42892,P09601,P36507,P05067,Q86UE4,Q07065,O75503,O15400,P50570,P22059,P27105,Q9BZF3,Q99523,O75312,O95071,Q92905,Q9H7Z7,O15027,Q01105,Q9BZG1,P51572,Q9H267,Q9UEU0 31 +Anchored component of synaptic membrane 0.4326500732064526 0.6363081918706387 0.5245755666448115 1.0 0.7047489375592908 2 Q9NQX3 1 +Chromatoid body 0.430087847730601 0.6239774286785559 0.5326424084804724 1.0 0.7112626723515674 2 Q08J23 1 +Cell tip 0.4840717685829367 0.6134201028369669 0.5395985970924619 1.0 0.7153473428033243 3 Q92930,Q9BTU6 2 +Lumenal side of membrane 0.4622441082696371 0.6001205562655557 0.5484258937786544 1.0 0.7205101619359475 10 P01889,P51572,Q8TCT9 3 +Cell pole 0.5362272280012732 0.5950317199449762 0.5518222682032148 1.0 0.7226827927283583 4 P08195 1 +Vacuolar lumen 0.2978830656868955 0.5302236823223936 0.5959568531015695 1.0 0.7624107932587373 63 Q8NHP8,P53634,O14773,P50897,Q14108,Q99536,Q9BWS9,Q9NZJ7,P46976,P08236,Q8IV08,P54802,P07602,O43681,P04062,P38435,Q9H7Z7 17 +Cytoplasmic stress granule 0.3051907099186667 0.5278344508259449 0.5976142435792227 1.0 0.7634262880405098 45 Q71RC2,Q93062,Q01085,P67809,Q14671,Q14157,P61978,Q9NUL3,Q9BWF3,P31483 10 +Mitotic cohesin complex 0.4040995607613494 0.5027558937088481 0.6151359070129381 1.0 0.7750126137012187 2 Q9UQE7 1 +Intrinsic component of nuclear inner membrane 0.4924749357333757 0.4979359272205184 0.6185292035613259 1.0 0.7777806770244838 6 Q14739 1 +Late endosome membrane 0.319498440206561 0.4832995699274717 0.628883045380829 1.0 0.7879218090338461 32 Q9HC07,Q14108,O15118,O95772,P51809,Q9H267,Q9UEU0 7 +Basolateral plasma membrane 0.3164783987700129 0.4815028081763743 0.6301591843743544 1.0 0.7879218090338461 33 P11166,P30825,Q14168,P41440,P05023,P57105,O14936,P08195 8 +Leading edge membrane 0.3068476018803099 0.4529451343828186 0.6505882495302497 1.0 0.8077528266639618 36 P23396,P50570,Q14168,P25054,P31751,P51790,Q9BZG1,Q13153 8 +Ficolin 1 rich granule membrane 0.3434514666729856 0.4219094633747276 0.673091102344856 1.0 0.8345196836926405 18 Q93050,P42785 2 +Tertiary granule 0.3005528750560752 0.4136060949043652 0.6791626088760552 1.0 0.8394086566851003 39 P09960,Q93050,P42785 3 +Cytoplasmic side of endoplasmic reticulum membrane 0.4706172461552541 0.4126168067161005 0.6798873856873067 1.0 0.8394086566851003 6 Q8TCT9 1 +Myosin filament 0.4335408275357013 0.407599043252338 0.6835680668327782 1.0 0.8416074806130583 3 P35580,P35579 2 +Neuron spine 0.3183421054424986 0.4045092854413391 0.6858382511665337 1.0 0.8420569639322442 29 P05067,P61006,Q14168 3 +Spindle midzone 0.3552423486435661 0.3897663563535852 0.696709323846741 1.0 0.8518548302635118 15 Q13432 1 +Post mrna release spliceosomal complex 0.4802752229737155 0.3754258077532142 0.7073438143818966 1.0 0.8594104088672232 5 Q9BZJ0,P52272 2 +Microbody lumen 0.343480899702881 0.3627428314555207 0.7167970009321405 1.0 0.8655497685787248 16 O15254,Q13011,O14734,Q15067 4 +Cytoplasmic region 0.2889982401493248 0.3605972170540441 0.7184005700170173 1.0 0.8655497685787248 53 Q8NEB9,Q99729,Q9UQB8,Q14168,P07196,Q13363,Q10713,Q9NUL3,O60313 9 +Recycling endosome membrane 0.3298896005595932 0.3559804361225361 0.721855216480014 1.0 0.8670108850113212 20 P61006,O15126,O15127,P01889,Q9UEU0 5 +Ruffle membrane 0.3147945267950371 0.3430737182772251 0.7315430023610172 1.0 0.870279116895034 27 P23396,P50570,P25054,P31751,P51790,Q9BZG1,Q13153 7 +Nuclear membrane 0.2649624630659615 0.3384903909113081 0.7349936671426622 1.0 0.8721267137639106 93 P14373,P67809,Q9H1E5,Q9P035,Q5SNT2,Q15154,Q86UE4,Q9NUL3,P62995,Q13153,Q99720,Q8N1F7,Q9BZF3,Q99523,Q9UBM7,Q14739,O75844,Q5BJF2,Q9BTX1,P43243,P50402 21 +Schaffer collateral ca1 synapse 0.3758643640990144 0.3291822056595491 0.7420179719480466 1.0 0.8769303304840551 12 Q9UQB8,O14936,Q16352 3 +Intrinsic component of synaptic vesicle membrane 0.4265854969881294 0.3263122136090606 0.74418814841237 1.0 0.8771497642620468 8 O76024,O15126,Q86Y82 3 +Basal part of cell 0.2910474022344758 0.3245670860951687 0.7455087411479306 1.0 0.8775362545602806 39 P42785,Q14168,P30825,P41440,O14936 5 +Nuclear envelope 0.2573777387767781 0.3168656688630858 0.7513455329730179 1.0 0.8816891365503476 158 Q12981,P14373,P11802,O15118,P67809,Q9H1E5,Q96P70,Q99567,Q9P035,Q9NQC3,Q96AG4,Q5SNT2,Q15154,P02545,P05067,Q86UE4,Q9NUL3,P62995,Q13153,Q15125,Q8TD16,Q99720,O95619,O15173,P57088,Q9BZF3,Q8N1F7,Q99523,Q8NFH4,Q5JVF3,P80303,Q9UBM7,Q14739,O75844,Q5BJF2,P42167,Q96S66,Q8N2G8,Q9BTX1,P43243,P50402 41 +Chloride channel complex 0.4561031082169181 0.3092407518944678 0.7571383965320131 1.0 0.8865037649460922 4 Q96S66 1 +Nurd complex 0.4387829912023465 0.2970793943065969 0.7664058955527404 1.0 0.8939440918263634 6 Q14839,Q92769,Q13330,Q86YP4,O94776 5 +Smooth endoplasmic reticulum 0.396106551721397 0.2916724342432103 0.7705370874883857 1.0 0.8962562964996486 10 P05067 1 +Blood microparticle 0.3293811310117547 0.2787602965305366 0.7804287858406729 1.0 0.9030092234072706 16 P11166,P04062,P38435 3 +Apical junction complex 0.3057961605647311 0.2746962812794156 0.783549588408263 1.0 0.9044990398934932 27 Q4VCS5,Q68EM7,Q9NR77,P25054 4 +Presynaptic membrane 0.3616601566009691 0.2609030523104261 0.7941672709462504 1.0 0.9128350468826484 12 Q96CX2,Q06787,O14936 3 +Proton transporting atp synthase complex 0.3969193883208153 0.2514261087596875 0.8014846840076615 1.0 0.9175737313337582 9 P36542,P06576,Q96IX5,O75964 4 +Myosin ii complex 0.4336996336996355 0.241317477691028 0.8093090658696847 1.0 0.9231344699726468 4 P35579,P35580,P60660 3 +Bleb 0.4250605021670706 0.2168975874363426 0.8282881578001087 1.0 0.937524624193721 4 Q9BRK5 1 +Cytoplasmic microtubule 0.314591562335753 0.1952925975583152 0.8451638917968627 1.0 0.9457172448526814 16 Q9H6U6,Q9BSJ2,P25054,Q6NUQ4,Q9Y5M8 5 +Clathrin coated endocytic vesicle membrane 0.3467359516914979 0.1932260082597659 0.846781970895693 1.0 0.9457172448526814 12 Q14108 1 +Mrna cleavage factor complex 0.3617373634372873 0.1932085070706846 0.8467956765849263 1.0 0.9457172448526814 11 Q05048 1 +Neuron to neuron synapse 0.2732793308634895 0.1928075163612415 0.8471097167378163 1.0 0.9457172448526814 54 Q9NQC3,P61006,Q99720,Q9UQB8,Q14168,P51991,P55795 7 +Ciliary tip 0.4062943596677076 0.1925719898363642 0.8472941831711807 1.0 0.9457172448526814 6 A0AVF1,Q96FJ2 2 +Mediator complex 0.4023649939465349 0.1809945430142385 0.8563718593205494 1.0 0.9510461352253337 6 P11802,O75448,Q15648 3 +Epsilon dna polymerase complex 0.4084249084249102 0.1728754138644145 0.8627493575552587 1.0 0.9569196854185092 4 Q9NR33,Q07864,Q9NRF9 3 +Trans golgi network transport vesicle 0.3512073145935803 0.1513432184953575 0.879704978464412 1.0 0.967237812142463 11 P61006 1 +Mcm complex 0.3907624633431089 0.1482615861781141 0.8821363300490748 1.0 0.9683114090897604 6 P49736,Q14566,P25205,P33993,P33992 5 +Polysomal ribosome 0.2899097382299547 0.1431669995999298 0.8861582918027331 1.0 0.9683114090897604 25 P62917,P62266,Q02543,P63220,P83881 5 +Nata complex 0.3462742246905921 0.1330944915863357 0.894118651468252 1.0 0.9710084617910748 3 P41227 1 +Pml body 0.2951323153251052 0.1294197293427911 0.8970255372057026 1.0 0.972037607318553 19 P60228,Q9ULX6 2 +Calcium channel complex 0.3699858687053438 0.1280987585107923 0.8980708185199846 1.0 0.972037607318553 8 P62942,Q15257 2 +Axolemma 0.3346759428780667 0.1068845675853301 0.914880556332339 1.0 0.9826906583205196 3 O94832,Q9Y2J2 2 +Cell projection membrane 0.2622418268684539 0.0876588134338667 0.9301478556759808 1.0 0.9966675205061418 53 P23396,P50570,Q14168,P25054,P31751,P41440,Q13325,P40855,P51790,O14936,Q9BZG1,Q13153 12 +Annulate lamellae 0.3753697280017988 0.0821446435129576 0.9345316926668552 1.0 1.0 5 Q8TD16 1 +Clathrin coated endocytic vesicle 0.2896157609181888 0.0678794356689646 0.9458816089482404 1.0 1.0 16 Q14108 1 +Polysome 0.2582796719008555 0.0638591255820864 0.9490823988749963 1.0 1.0 44 O43347,P62917,P23396,P62266,Q9Y3U8,Q02543,P63220,P61758,P83881,Q06787,P60900,Q9Y295,Q8TCS8,P08670 14 +Striated muscle thin filament 0.3653352876511497 0.0627173070334341 0.949991615504967 1.0 1.0 5 P09493,P06753,P28289,P67936 4 +Myofilament 0.3653352876511497 0.0627173070334341 0.949991615504967 1.0 1.0 5 P09493,P06753,P28289,P67936 4 +Transcription factor tfiih holo complex 0.3091210294116046 0.0585157376210471 0.953337827165109 1.0 1.0 3 P19447 1 +Eukaryotic translation initiation factor 2b complex 0.34228464021805 0.0367145510849709 0.9707126063776252 1.0 1.0 6 P49770,Q9NR50 2 +Unconventional myosin complex 0.2808495056755766 0.0195624189298215 0.9843924434416632 1.0 1.0 3 Q96FJ2,P60660 2 +F actin capping protein complex 0.3374862587028164 0.0173712983197341 0.9861404063228856 1.0 1.0 5 P58546,P35611,P52907,P47756 4 +Peptidase complex 0.2537966423752285 0.0140800791297975 0.9887660934331062 1.0 1.0 52 Q15005,P20618,P49721,O43242,P28072,Q99436,P48556,P28070,P67812,Q05086 10 +Postsynaptic cytosol 0.3274103967204884 0.0109751219182406 0.991243295464521 1.0 1.0 6 Q9UQB8 1 +Sec61 translocon complex 0.3192908630064335 0.0107268731001128 0.9914413577025564 1.0 1.0 4 P51571 1 +Translocon complex 0.3192908630064335 0.0107268731001128 0.9914413577025564 1.0 1.0 4 P51571 1 +Saga type complex 0.2610765287440498 0.0005272917273483 0.9995792820912056 1.0 1.0 3 Q9NR33,Q9NRF9 2 +Atac complex 0.2610765287440498 0.0005272917273483 0.9995792820912056 1.0 1.0 3 Q9NR33,Q9NRF9 2 +Early endosome membrane 0.2522081671866697 0.0001103307708533 0.9999119687815332 1.0 1.0 41 Q9HC07,O15400,P51790,Q8IV08,Q96J02,P01889,Q9H267,Q9BZF3,Q9UEU0 9 diff --git a/msigdb_gocc/selections.json b/msigdb_gocc/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..ddc916f3f4efd3fd3f4f87f6c599153503e45248 --- /dev/null +++ b/msigdb_gocc/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["90s preribosome", "9plus0 non motile cilium", "9plus2 motile cilium", "A band", "Acrosomal membrane", "Acrosomal vesicle", "Actin based cell projection", "Actin cytoskeleton", "Actin filament", "Actin filament bundle", "Actomyosin", "Adherens junction", "Aggresome", "Alpha dna polymerase primase complex", "Alveolar lamellar body", "Aminoacyl trna synthetase multienzyme complex", "Ampa glutamate receptor complex", "Amphisome", "Amphisome membrane", "Anaphase promoting complex", "Anchored component of membrane", "Anchored component of plasma membrane", "Anchored component of postsynaptic membrane", "Anchored component of synaptic membrane", "Anchored component of synaptic vesicle membrane", "Anchoring junction", "Annulate lamellae", "Ap 1 adaptor complex", "Ap 3 adaptor complex", "Ap type membrane coat adaptor complex", "Apical dendrite", "Apical junction complex", "Apical part of cell", "Apical plasma membrane", "Apicolateral plasma membrane", "Arp2 3 protein complex", "Aryl hydrocarbon receptor complex", "Aster", "Astrocyte end foot", "Astrocyte projection", "Atac complex", "Atpase complex", "Atpase dependent transmembrane transport complex", "Autolysosome", "Autophagosome", "Autophagosome membrane", "Axolemma", "Axon", "Axon cytoplasm", "Axon hillock", "Axon initial segment", "Axonal growth cone", "Azurophil granule", "Azurophil granule lumen", "Azurophil granule membrane", "B wich complex", "Barr body", "Basal cortex", "Basal dendrite", "Basal part of cell", "Basement membrane", "Basolateral plasma membrane", "Bcl 2 family protein complex", "Beta catenin destruction complex", "Beta catenin tcf complex", "Bleb", "Blood microparticle", "Box c d rnp complex", "Box h aca rnp complex", "Box h aca snornp complex", "Box h aca telomerase rnp complex", "Brca1 a complex", "Brca1 c complex", "Brisc complex", "Brush border", "Brush border membrane", "Cajal body", "Calcium and calmodulin dependent protein kinase complex", "Calcium channel complex", "Camp dependent protein kinase complex", "Carboxy terminal domain protein kinase complex", "Caspase complex", "Catalytic complex", "Catalytic step 1 spliceosome", "Catalytic step 2 spliceosome", "Catenin complex", "Cation channel complex", "Cation transporting atpase complex", "Catsper complex", "Caveola", "Ccaat binding factor complex", "Ccr4 not complex", "Ccr4 not core complex", "Cd40 receptor complex", "Cd95 death inducing signaling complex", "Cdc73 paf1 complex", "Cell body", "Cell body membrane", "Cell cell contact zone", "Cell cell junction", "Cell cortex", "Cell cortex region", "Cell division site", "Cell leading edge", "Cell pole", "Cell projection membrane", "Cell substrate junction", "Cell surface", "Cell tip", "Cell trailing edge", "Centriolar satellite", "Centriolar subdistal appendage", "Centriole", "Centrosome", "Cerebellar mossy fiber", "Chaperone complex", "Chaperonin containing t complex", "Checkpoint clamp complex", "Chitosome", "Chloride channel complex", "Cholinergic synapse", "Chromaffin granule", "Chromaffin granule membrane", "Chromatin", "Chromatin silencing complex", "Chromatoid body", "Chromocenter", "Chromosomal region", "Chromosome", "Chromosome centromeric core domain", "Chromosome centromeric region", "Chromosome passenger complex", "Chromosome telomeric region", "Chromosome telomeric repeat region", "Cia complex", "Ciliary basal body", "Ciliary base", "Ciliary membrane", "Ciliary plasm", "Ciliary rootlet", "Ciliary tip", "Ciliary transition zone", "Cilium", "Cis golgi network", "Cis golgi network membrane", "Clathrin adaptor complex", "Clathrin coat", "Clathrin coat of coated pit", "Clathrin coat of endocytic vesicle", "Clathrin coated endocytic vesicle", "Clathrin coated endocytic vesicle membrane", "Clathrin coated pit", "Clathrin coated vesicle", "Clathrin coated vesicle membrane", "Clathrin complex", "Clathrin sculpted gamma aminobutyric acid transport vesicle", "Clathrin sculpted vesicle", "Clathrin vesicle coat", "Cleavage furrow", "Cluster of actin based cell projections", "Coated vesicle", "Coated vesicle membrane", "Cohesin complex", "Collagen containing extracellular matrix", "Collagen trimer", "Commitment complex", "Compact myelin", "Condensed chromosome", "Condensed chromosome centromeric region", "Condensed nuclear chromosome", "Condensin complex", "Contractile fiber", "Contractile ring", "Cop9 signalosome", "Copi coated vesicle", "Copi coated vesicle membrane", "Copi vesicle coat", "Copii coated er to golgi transport vesicle", "Copii vesicle coat", "Core mediator complex", "Cornified envelope", "Cortical actin cytoskeleton", "Cortical cytoskeleton", "Cortical endoplasmic reticulum", "Cortical granule", "Costamere", "Crd mediated mrna stability complex", "Ctf18 rfc like complex", "Cul2 ring ubiquitin ligase complex", "Cul3 ring ubiquitin ligase complex", "Cul4 ring e3 ubiquitin ligase complex", "Cul4a ring e3 ubiquitin ligase complex", "Cul4b ring e3 ubiquitin ligase complex", "Cul5 ring ubiquitin ligase complex", "Cullin ring ubiquitin ligase complex", "Cuticular plate", "Cyclin a2 cdk2 complex", "Cyclin cdk positive transcription elongation factor complex", "Cyclin dependent protein kinase holoenzyme complex", "Cytochrome complex", "Cytolytic granule", "Cytoplasmic dynein complex", "Cytoplasmic exosome rnase complex", "Cytoplasmic microtubule", "Cytoplasmic region", "Cytoplasmic side of endoplasmic reticulum membrane", "Cytoplasmic side of endosome membrane", "Cytoplasmic side of lysosomal membrane", "Cytoplasmic side of membrane", "Cytoplasmic stress granule", "Cytoplasmic ubiquitin ligase complex", "Cytosolic large ribosomal subunit", "Cytosolic region", "Cytosolic ribosome", "Cytosolic small ribosomal subunit", "Death inducing signaling complex", "Dendrite cytoplasm", "Dendrite membrane", "Dendrite terminus", "Dendritic growth cone", "Dendritic shaft", "Dendritic spine membrane", "Dendritic tree", "Dense body", "Dentate gyrus mossy fiber", "Derlin 1 retrotranslocation complex", "Desmosome", "Dihydrolipoyl dehydrogenase complex", "Distal axon", "Dna packaging complex", "Dna polymerase complex", "Dna repair complex", "Dna replication factor c complex", "Dna replication preinitiation complex", "Dopaminergic synapse", "Dynactin complex", "Dynein axonemal particle", "Dynein complex", "Dystrophin associated glycoprotein complex", "Early endosome", "Early endosome lumen", "Early endosome membrane", "Early phagosome", "Ekc keops complex", "Elongator holoenzyme complex", "Elongin complex", "Emc complex", "Endocytic vesicle", "Endocytic vesicle lumen", "Endocytic vesicle membrane", "Endolysosome", "Endolysosome lumen", "Endolysosome membrane", "Endopeptidase complex", "Endoplasmic reticulum", "Endoplasmic reticulum chaperone complex", "Endoplasmic reticulum exit site", "Endoplasmic reticulum golgi intermediate compartment", "Endoplasmic reticulum golgi intermediate compartment membrane", "Endoplasmic reticulum lumen", "Endoplasmic reticulum palmitoyltransferase complex", "Endoplasmic reticulum plasma membrane contact site", "Endoplasmic reticulum protein containing complex", "Endoplasmic reticulum quality control compartment", "Endoplasmic reticulum tubular network", "Endoplasmic reticulum tubular network membrane", "Endoribonuclease complex", "Endosome", "Endosome lumen", "Endosome membrane", "Envelope", "Enzyme activator complex", "Epsilon dna polymerase complex", "Equatorial microtubule organizing center", "Er membrane insertion complex", "Er to golgi transport vesicle membrane", "Er ubiquitin ligase complex", "Esc e z complex", "Escrt complex", "Escrt i complex", "Escrt iii complex", "Euchromatin", "Eukaryotic translation initiation factor 2 complex", "Eukaryotic translation initiation factor 2b complex", "Eukaryotic translation initiation factor 3 complex", "Eukaryotic translation initiation factor 3 complex eif3m", "Eukaryotic translation initiation factor 4f complex", "Excitatory synapse", "Exocyst", "Exocytic vesicle", "Exon exon junction complex", "Exoribonuclease complex", "External encapsulating structure", "External side of apical plasma membrane", "External side of plasma membrane", "Extrinsic component of cytoplasmic side of plasma membrane", "Extrinsic component of endoplasmic reticulum membrane", "Extrinsic component of endosome membrane", "Extrinsic component of external side of plasma membrane", "Extrinsic component of membrane", "Extrinsic component of mitochondrial inner membrane", "Extrinsic component of organelle membrane", "Extrinsic component of plasma membrane", "Extrinsic component of postsynaptic membrane", "Extrinsic component of postsynaptic specialization membrane", "Extrinsic component of synaptic membrane", "F actin capping protein complex", "Fascia adherens", "Female germ cell nucleus", "Female pronucleus", "Fhf complex", "Fibrillar center", "Ficolin 1 rich granule", "Ficolin 1 rich granule lumen", "Ficolin 1 rich granule membrane", "Filamentous actin", "Filopodium", "Filopodium membrane", "Filopodium tip", "Filtration diaphragm", "Flemming body", "Flotillin complex", "Gaba ergic synapse", "Gamma secretase complex", "Gamma tubulin complex", "Gap junction", "Gator2 complex", "Gemini of coiled bodies", "Germ cell nucleus", "Gid complex", "Glial cell projection", "Glutamatergic synapse", "Glycinergic synapse", "Glycogen granule", "Glycoprotein complex", "Golgi apparatus", "Golgi apparatus subcompartment", "Golgi associated vesicle", "Golgi associated vesicle membrane", "Golgi cis cisterna", "Golgi cisterna", "Golgi cisterna membrane", "Golgi lumen", "Golgi medial cisterna", "Golgi membrane", "Golgi stack", "Golgi transport complex", "Gpi anchor transamidase complex", "Granular component", "Growth cone membrane", "Gtpase complex", "Guanyl nucleotide exchange factor complex", "H3 histone acetyltransferase complex", "H4 h2a histone acetyltransferase complex", "H4 histone acetyltransferase complex", "Haus complex", "Hemidesmosome", "Hemoglobin complex", "Heterochromatin", "Hfe transferrin receptor complex", "High density lipoprotein particle", "Hippocampal mossy fiber", "Hippocampal mossy fiber to ca3 synapse", "Histone deacetylase complex", "Histone methyltransferase complex", "Histone pre mrna 3 end processing complex", "Hops complex", "Host cellular component", "Hrd1p ubiquitin ligase erad l complex", "Hulc complex", "I band", "Immunological synapse", "Inclusion body", "Inflammasome complex", "Inhibitory synapse", "Inner mitochondrial membrane protein complex", "Ino80 complex", "Ino80 type complex", "Insulin responsive compartment", "Integral component of cytoplasmic side of endoplasmic reticulum membrane", "Integral component of lysosomal membrane", "Integral component of presynaptic active zone membrane", "Integral component of synaptic vesicle membrane", "Integrator complex", "Integrin complex", "Intercalated disc", "Intercellular bridge", "Intercellular canaliculus", "Intermediate filament", "Intermediate filament cytoskeleton", "Intracellular protein containing complex", "Intraciliary transport particle", "Intraciliary transport particle b", "Intrinsic component of endoplasmic reticulum membrane", "Intrinsic component of golgi membrane", "Intrinsic component of mitochondrial inner membrane", "Intrinsic component of mitochondrial membrane", "Intrinsic component of mitochondrial outer membrane", "Intrinsic component of nuclear inner membrane", "Intrinsic component of organelle membrane", "Intrinsic component of peroxisomal membrane", "Intrinsic component of plasma membrane", "Intrinsic component of postsynaptic density membrane", "Intrinsic component of postsynaptic membrane", "Intrinsic component of postsynaptic specialization membrane", "Intrinsic component of presynaptic active zone membrane", "Intrinsic component of presynaptic membrane", "Intrinsic component of synaptic membrane", "Intrinsic component of synaptic vesicle membrane", "Intrinsic component of vacuolar membrane", "Ion channel complex", "Iron sulfur cluster assembly complex", "Iswi type complex", "Juxtaparanode region of axon", "Keratin filament", "Kinesin complex", "Kinetochore microtubule", "Lamellar body", "Lamellipodium", "Lamellipodium membrane", "Lamin filament", "Large ribosomal subunit", "Late endosome", "Late endosome membrane", "Lateral element", "Lateral part of cell", "Lateral plasma membrane", "Leading edge membrane", "Lewy body", "Lipid droplet", "Lipopolysaccharide receptor complex", "Low density lipoprotein particle", "Lsm1 7 pat1 complex", "Lsm2 8 complex", "Lumenal side of endoplasmic reticulum membrane", "Lumenal side of membrane", "Lysosomal lumen", "M band", "Magnesium dependent protein serine threonine phosphatase complex", "Main axon", "Male germ cell nucleus", "Male pronucleus", "Manchette", "Mcm complex", "Mcrd mediated mrna stability complex", "Mediator complex", "Meiotic cohesin complex", "Meiotic spindle", "Membrane coat", "Membrane microdomain", "Membrane protein complex", "Messenger ribonucleoprotein complex", "Methylosome", "Methyltransferase complex", "Mhc class i peptide loading complex", "Mhc class i protein complex", "Mhc protein complex", "Mib complex", "Micos complex", "Microbody", "Microbody lumen", "Microbody membrane", "Microfibril", "Microtubule", "Microtubule associated complex", "Microtubule bundle", "Microtubule cytoskeleton", "Microtubule end", "Microtubule minus end", "Microtubule organizing center", "Microtubule organizing center attachment site", "Microtubule plus end", "Microvillus", "Microvillus membrane", "Midbody", "Mismatch repair complex", "Mitochondria associated endoplasmic reticulum membrane", "Mitochondrial alpha ketoglutarate dehydrogenase complex", "Mitochondrial crista", "Mitochondrial envelope", "Mitochondrial intermembrane space protein transporter complex", "Mitochondrial large ribosomal subunit", "Mitochondrial matrix", "Mitochondrial permeability transition pore complex", "Mitochondrial protein containing complex", "Mitochondrial proton transporting atp synthase complex coupling factor f o", "Mitochondrial pyruvate dehydrogenase complex", "Mitochondrial small ribosomal subunit", "Mitochondrial tricarboxylic acid cycle enzyme complex", "Mitochondrion", "Mitotic cohesin complex", "Mitotic spindle", "Mitotic spindle astral microtubule", "Mitotic spindle microtubule", "Mitotic spindle midzone", "Mitotic spindle pole", "Mll1 2 complex", "Mll3 4 complex", "Mmxd complex", "Motile cilium", "Mpp7 dlg1 lin7 complex", "Mrna cleavage and polyadenylation specificity factor complex", "Mrna cleavage factor complex", "Mrna editing complex", "Multimeric ribonuclease p complex", "Multivesicular body", "Multivesicular body membrane", "Myelin sheath", "Myelin sheath abaxonal region", "Myelin sheath adaxonal region", "Myofilament", "Myosin complex", "Myosin filament", "Myosin ii complex", "N terminal protein acetyltransferase complex", "Nadh dehydrogenase complex", "Nascent polypeptide associated complex", "Nata complex", "Nbaf complex", "Neurofibrillary tangle", "Neurofilament", "Neuromuscular junction", "Neuron projection", "Neuron projection cytoplasm", "Neuron projection membrane", "Neuron projection terminus", "Neuron spine", "Neuron to neuron synapse", "Neuronal ribonucleoprotein granule", "Neurotransmitter receptor complex", "Nlrp3 inflammasome complex", "Nls dependent protein nuclear import complex", "Node of ranvier", "Non motile cilium", "Nonhomologous end joining complex", "Npbaf complex", "Nsl complex", "Nuclear body", "Nuclear chromosome", "Nuclear cyclin dependent protein kinase holoenzyme complex", "Nuclear envelope", "Nuclear envelope lumen", "Nuclear exosome rnase complex", "Nuclear inclusion body", "Nuclear inner membrane", "Nuclear lamina", "Nuclear membrane", "Nuclear outer membrane", "Nuclear outer membrane endoplasmic reticulum membrane network", "Nuclear periphery", "Nuclear pore", "Nuclear pore central transport channel", "Nuclear pore nuclear basket", "Nuclear pore outer ring", "Nuclear protein containing complex", "Nuclear replication fork", "Nuclear rna export factor complex", "Nuclear speck", "Nuclear stress granule", "Nuclear ubiquitin ligase complex", "Nucleocytoplasmic transport complex", "Nucleoid", "Nucleolar ribonuclease p complex", "Nucleolus", "Nucleotide activated protein kinase complex", "Nucleotide excision repair complex", "Nurd complex", "Nurf complex", "Oligosaccharyltransferase complex", "Organellar ribosome", "Organelle envelope lumen", "Organelle inner membrane", "Organelle membrane contact site", "Organelle subcompartment", "Origin recognition complex", "Outer dense fiber", "Outer kinetochore", "Outer membrane", "Outer mitochondrial membrane protein complex", "Oxidoreductase complex", "Oxoglutarate dehydrogenase complex", "P body", "Palmitoyltransferase complex", "Pam complex tim23 associated import motor", "Parallel fiber to purkinje cell synapse", "Paranodal junction", "Paranode region of axon", "Paraspeckles", "Pcg protein complex", "Peptidase complex", "Peptidase inhibitor complex", "Pericentric heterochromatin", "Pericentriolar material", "Periciliary membrane compartment", "Perikaryon", "Perinuclear endoplasmic reticulum", "Perinuclear region of cytoplasm", "Perinucleolar compartment", "Phagocytic cup", "Phagocytic vesicle", "Phagocytic vesicle lumen", "Phagocytic vesicle membrane", "Phagolysosome", "Phagophore assembly site", "Phagophore assembly site membrane", "Phosphatase complex", "Phosphatidylinositol 3 kinase complex", "Phosphatidylinositol 3 kinase complex class iii", "Photoreceptor connecting cilium", "Photoreceptor inner segment", "Photoreceptor outer segment", "Photoreceptor ribbon synapse", "Pi body", "Picln sm protein complex", "Pigment granule", "Pinosome", "Pip body", "Plasma membrane protein complex", "Plasma membrane raft", "Plasma membrane region", "Plasma membrane signaling receptor complex", "Platelet alpha granule", "Platelet alpha granule lumen", "Platelet alpha granule membrane", "Platelet dense granule", "Platelet dense granule lumen", "Platelet dense granule membrane", "Platelet dense tubular network", "Platelet dense tubular network membrane", "Pml body", "Podosome", "Polar microtubule", "Pole plasm", "Polymeric cytoskeletal fiber", "Polysomal ribosome", "Polysome", "Pore complex", "Post mrna release spliceosomal complex", "Postsynapse", "Postsynaptic cytoskeleton", "Postsynaptic cytosol", "Postsynaptic density intracellular component", "Postsynaptic density membrane", "Postsynaptic endocytic zone", "Postsynaptic endosome", "Postsynaptic membrane", "Postsynaptic recycling endosome", "Postsynaptic specialization intracellular component", "Postsynaptic specialization membrane", "Potassium channel complex", "Prc1 complex", "Pre snornp complex", "Precatalytic spliceosome", "Prefoldin complex", "Preribosome", "Preribosome large subunit precursor", "Preribosome small subunit precursor", "Prespliceosome", "Presynapse", "Presynaptic active zone", "Presynaptic active zone cytoplasmic component", "Presynaptic active zone membrane", "Presynaptic cytoskeleton", "Presynaptic cytosol", "Presynaptic endocytic zone", "Presynaptic membrane", "Pronucleus", "Protease inhibitor complex", "Proteasome accessory complex", "Proteasome complex", "Proteasome core complex", "Proteasome core complex alpha subunit complex", "Proteasome core complex beta subunit complex", "Proteasome regulatory particle", "Proteasome regulatory particle base subcomplex", "Proteasome regulatory particle lid subcomplex", "Protein acetyltransferase complex", "Protein complex involved in cell adhesion", "Protein dna complex", "Protein kinase complex", "Protein lipid complex", "Protein phosphatase 4 complex", "Protein phosphatase type 1 complex", "Protein phosphatase type 2a complex", "Proton transporting atp synthase complex", "Proton transporting atp synthase complex catalytic core f 1", "Proton transporting atp synthase complex coupling factor f o", "Proton transporting two sector atpase complex", "Proton transporting two sector atpase complex catalytic domain", "Proton transporting two sector atpase complex proton transporting domain", "Proton transporting v type atpase complex", "Proton transporting v type atpase v0 domain", "Proton transporting v type atpase v1 domain", "Proximal dendrite", "Prp19 complex", "Pseudopodium", "Ptw pp1 phosphatase complex", "Pwp2p containing subcomplex of 90s preribosome", "R2tp complex", "Ragulator complex", "Rdna heterochromatin", "Receptor complex", "Recycling endosome", "Recycling endosome membrane", "Replication fork", "Replisome", "Respirasome", "Respiratory chain complex iii", "Respiratory chain complex iv", "Retromer complex", "Ribbon synapse", "Ribonuclease mrp complex", "Ribonuclease p complex", "Ribonucleoprotein complex", "Ribonucleoprotein granule", "Ribose phosphate diphosphokinase complex", "Ribosomal subunit", "Ribosome", "Ripoptosome", "Risc loading complex", "Rna cap binding complex", "Rna polymerase complex", "Rna polymerase i complex", "Rna polymerase ii core complex", "Rna polymerase ii holoenzyme", "Rna polymerase ii transcription regulator complex", "Rna polymerase ii transcription repressor complex", "Rna polymerase iii complex", "Rna polymerase iii transcription regulator complex", "Rnai effector complex", "Rough endoplasmic reticulum", "Rough endoplasmic reticulum membrane", "Rpap3 r2tp prefoldin like complex", "Ruffle", "Ruffle membrane", "Saga type complex", "Sarcolemma", "Sarcoplasm", "Sarcoplasmic reticulum lumen", "Sarcoplasmic reticulum membrane", "Scar complex", "Scf ubiquitin ligase complex", "Schaffer collateral ca1 synapse", "Sec61 translocon complex", "Secondary lysosome", "Secretory granule", "Secretory granule membrane", "Secretory vesicle", "Seh1 associated complex", "Septin cytoskeleton", "Serine protease inhibitor complex", "Set1c compass complex", "Sex chromatin", "Sex chromosome", "Shelterin complex", "Side of membrane", "Signal peptidase complex", "Signal recognition particle", "Sin3 complex", "Sin3 type complex", "Site of dna damage", "Site of double strand break", "Site of polarized growth", "Sm like protein family complex", "Small ribosomal subunit", "Small subunit processome", "Smc5 smc6 complex", "Smn complex", "Smn sm protein complex", "Smooth endoplasmic reticulum", "Smooth endoplasmic reticulum membrane", "Snare complex", "Sno s rna containing ribonucleoprotein complex", "Sodium potassium exchanging atpase complex", "Somatodendritic compartment", "Sorting endosome", "Specific granule", "Specific granule lumen", "Specific granule membrane", "Spectrin", "Spectrin associated cytoskeleton", "Sperm annulus", "Sperm connecting piece", "Sperm fibrous sheath", "Sperm head", "Sperm head plasma membrane", "Sperm midpiece", "Sperm plasma membrane", "Sperm principal piece", "Spermatoproteasome complex", "Spindle", "Spindle microtubule", "Spindle midzone", "Spindle pole", "Spindle pole centrosome", "Spliceosomal complex", "Spliceosomal snrnp complex", "Spliceosomal tri snrnp complex", "Stereocilium bundle", "Stereocilium tip", "Striated muscle thin filament", "Sumo ligase complex", "Supramolecular complex", "Supramolecular polymer", "Swi snf complex", "Swr1 complex", "Synapse", "Synaptic membrane", "Synaptic vesicle membrane", "Synaptonemal structure", "T tubule", "Telomerase holoenzyme complex", "Terminal bouton", "Tertiary granule", "Tertiary granule lumen", "Tertiary granule membrane", "Tetraspanin enriched microdomain", "Tho complex", "Tight junction", "Tim22 mitochondrial import inner membrane insertion complex", "Tim23 mitochondrial import inner membrane translocase complex", "Tor complex", "Torc1 complex", "Trans golgi network", "Trans golgi network membrane", "Trans golgi network transport vesicle", "Trans golgi network transport vesicle membrane", "Transcription elongation factor complex", "Transcription export complex", "Transcription export complex 2", "Transcription factor tfiid complex", "Transcription factor tfiih holo complex", "Transcription factor tfiiic complex", "Transcription preinitiation complex", "Transcription regulator complex", "Transcription repressor complex", "Transferase complex", "Transferase complex transferring phosphorus containing groups", "Translation preinitiation complex", "Translocon complex", "Transport vesicle", "Transport vesicle membrane", "Transporter complex", "Trapp complex", "Tricarboxylic acid cycle enzyme complex", "Triglyceride rich plasma lipoprotein particle", "Trna methyltransferase complex", "Trna splicing ligase complex", "Tubular endosome", "U1 snrnp", "U12 type spliceosomal complex", "U2 snrnp", "U2 type catalytic step 2 spliceosome", "U2 type spliceosomal complex", "U2af complex", "U4 snrnp", "U5 snrnp", "U6 snrnp", "U7 snrnp", "Ubiquinone biosynthesis complex", "Ubiquitin conjugating enzyme complex", "Ubiquitin ligase complex", "Unconventional myosin complex", "Uniplex complex", "Vacuolar lumen", "Vacuolar membrane", "Vacuolar proton transporting v type atpase v0 domain", "Vacuole", "Varicosity", "Vcp npl4 ufd1 aaa atpase complex", "Vesicle coat", "Vesicle lumen", "Vesicle membrane", "Vesicle tethering complex", "Voltage gated calcium channel complex", "Wash complex", "Weibel palade body", "Wnt signalosome", "X chromosome", "Xy body", "Zona pellucida receptor complex", "Zonula adherens", "Zymogen granule", "Zymogen granule membrane"], "available_proteins": ["AAAS", "AAR2", "AARS", "AARS2", "AASS", "AATF", "ABCB1", "ABCB10", "ABCB7", "ABCD3", "ABCE1", "ABCF1", "ABHD10", "ABHD12", "ABHD14B", "ABHD6", "ACAA2", "ACACA", "ACACB", "ACAD9", "ACADM", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACBD5", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT8", "ACOT9", "ACOX1", "ACOX3", "ACP1", "ACP2", "ACP6", "ACSL1", "ACSL3", "ACSL4", "ACTN1", "ACTN2", "ACTN4", "ACTR10", "ACTR1A", "ACTR2", "ACTR3", "ADA", "ADAR", "ADD1", "ADD3", "ADH5", "ADNP", "ADPGK", "ADPRHL2", "ADSS", "AFDN", "AFG3L2", "AGK", "AGL", "AGPAT1", "AGPS", "AHCTF1", "AHCY", "AHCYL1", "AHNAK", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AK4", "AK6", "AKAP12", "AKAP13", "AKAP8", "AKAP8L", "AKR1A1", "AKR7A2", "AKT2", "ALDH18A1", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDOA", "ALDOC", "ALG1", "ALKBH5", "ALYREF", "AMOT", "ANAPC1", "ANAPC16", "ANAPC4", "ANAPC5", "ANAPC7", "ANK3", "ANKFY1", "ANKLE2", "ANKRD50", "ANLN", "ANP32A", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP1M1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "APC", "APEH", "APEX1", "API5", "APMAP", "APOL2", "APOOL", "APP", "APPL1", "APRT", "AQR", "ARCN1", "ARF4", "ARF5", "ARFGAP1", "ARFIP1", "ARFIP2", "ARHGAP17", "ARHGDIA", "ARHGEF2", "ARID1A", "ARIH1", "ARL1", "ARL2", "ARL3", "ARL6IP1", "ARL6IP5", "ARL8B", "ARMC1", "ARMC8", "ARMCX3", "ARPC1A", "ARPC2", "ARPC3", "ARPC4", "ARPC5", "ASAH1", "ASCC3", "ASF1A", "ASNA1", "ASPH", "ATAD1", "ATAD3A", "ATAD3B", "ATAD5", "ATG7", "ATL2", "ATP13A1", "ATP1A1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5L", "ATP5O", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1D", "ATP6V1E1", "ATP6V1H", "ATPAF1", "ATPIF1", "ATXN10", "ATXN2L", "AUP1", "AURKA", "B3GALT6", "B4GAT1", "BABAM1", "BAG2", "BAG5", "BAG6", "BAIAP2", "BAK1", "BANF1", "BAP18", "BASP1", "BAZ1A", "BAZ1B", "BCAP31", "BCAS2", "BCAS3", "BCCIP", "BCL2L13", "BCLAF1", "BCS1L", "BDH2", "BICD2", "BIRC6", "BMS1", "BNIP1", "BOP1", "BPTF", "BRD4", "BRI3BP", "BRIX1", "BSG", "BTF3", "BUB1", "BUB1B", "BUB3", "BUD31", "BYSL", "C12orf43", "C12orf73", "C19orf70", "C1QBP", "C1orf35", "CACYBP", "CAD", "CALD1", "CALM3", "CALR", "CALU", "CAMK2G", "CAND1", "CANX", "CAP1", "CAPN1", "CAPNS1", "CAPRIN1", "CAPZA1", "CAPZB", "CARHSP1", "CARS2", "CASK", "CASP3", "CASP8", "CAST", "CBX1", "CBX3", "CBX5", "CBX8", "CCAR1", "CCAR2", "CCDC124", "CCDC134", "CCDC137", "CCDC22", "CCDC47", "CCDC86", "CCDC93", "CCDC94", "CCNB1", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2AP", "CD2BP2", "CD3EAP", "CD47", "CDC16", "CDC23", "CDC27", "CDC37", "CDC40", "CDC42", "CDC45", "CDC5L", "CDC73", "CDCA5", "CDIPT", "CDK1", "CDK12", "CDK2", "CDK4", "CDK5RAP3", "CDK6", "CDKN2AIP", "CDS2", "CDX2", "CEBPZ", "CELF1", "CENPV", "CEP44", "CEP55", "CERS1", "CERS2", "CETN2", "CFAP20", "CFL1", "CFL2", "CHAF1B", "CHAMP1", "CHCHD3", "CHD1", "CHD4", "CHEK2", "CHERP", "CHID1", "CHML", "CHMP1A", "CHMP2B", "CHMP5", "CHMP6", "CHMP7", "CHORDC1", "CHRAC1", "CHST14", "CIAPIN1", "CIRBP", "CISD1", "CISD2", "CKAP2", "CKAP4", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLCC1", "CLCN3", "CLGN", "CLIC1", "CLIC4", "CLINT1", "CLN5", "CLNS1A", "CLPB", "CLPP", "CLPTM1", "CLPX", "CLTA", "CLTC", "CMPK1", "CNN2", "CNN3", "CNNM4", "CNOT1", "CNOT7", "CNOT9", "CNP", "CNPY2", "COA3", "COA7", "COASY", "COG2", "COG6", "COIL", "COLEC12", "COLGALT1", "COMT", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS7A", "COPS7B", "COPS8", "COPZ1", "COQ8A", "COQ9", "CORO1B", "CORO1C", "COTL1", "COX15", "COX2", "COX4I1", "COX5A", "COX5B", "COX6C", "COX7A2", "COX7C", "CPNE1", "CPNE3", "CPOX", "CPPED1", "CPSF1", "CPSF2", "CPSF3", "CPSF6", "CPSF7", "CPT1A", "CPT2", "CRKL", "CRMP1", "CRNKL1", "CRTAP", "CS", "CSDE1", "CSE1L", "CSK", "CSNK1A1", "CSNK2A2", "CSNK2B", "CSTB", "CSTF1", "CSTF2", "CTBP1", "CTBP2", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTR9", "CTSA", "CTSC", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4A", "CUL4B", "CUL5", "CWF19L1", "CXorf57", "CYB5B", "CYB5R3", "CYC1", "CYFIP1", "CYP51A1", "DAD1", "DAGLB", "DAP3", "DARS", "DARS2", "DAZAP1", "DBN1", "DBNL", "DCAF1", "DCAF13", "DCAF7", "DCP1A", "DCPS", "DCTN1", "DCTN2", "DCTN3", "DCTN4", "DCTN6", "DCTPP1", "DCUN1D4", "DCUN1D5", "DCXR", "DDB1", "DDI2", "DDOST", "DDRGK1", "DDX1", "DDX17", "DDX18", "DDX20", "DDX21", "DDX23", "DDX24", "DDX27", "DDX28", "DDX39A", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX5", "DDX50", "DDX51", "DDX52", "DDX54", "DDX55", "DDX56", "DDX6", "DEK", "DERL1", "DFFA", "DHCR24", "DHCR7", "DHFR", "DHRS7B", "DHX15", "DHX16", "DHX30", "DHX36", "DHX37", "DHX38", "DHX8", "DHX9", "DIABLO", "DIAPH1", "DICER1", "DIDO1", "DIEXF", "DIP2B", "DIS3", "DKC1", "DLAT", "DLD", "DLST", "DNAAF5", "DNAJA1", "DNAJA3", "DNAJB1", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC2", "DNAJC3", "DNAJC8", "DNAJC9", "DNM1L", "DNM2", "DNMT1", "DNTTIP2", "DOCK7", "DOLPP1", "DPF2", "DPP9", "DPYSL2", "DPYSL3", "DRG1", "DSG2", "DSP", "DST", "DSTN", "DTL", "DTYMK", "DUSP3", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNLL1", "DYNLL2", "EARS2", "EBNA1BP2", "EBP", "ECE1", "ECH1", "ECHS1", "ECI1", "ECI2", "ECSIT", "EDC3", "EDC4", "EDF1", "EEA1", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EEFSEC", "EFL1", "EFTUD2", "EHD1", "EHD4", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2D", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5A", "EIF6", "ELAC2", "ELAVL1", "ELOB", "ELOC", "ELP1", "ELP2", "ELP3", "EMC1", "EMC2", "EMC3", "EMC4", "EMD", "EMG1", "EML4", "ENAH", "ENO1", "EPB41", "EPB41L2", "EPB41L3", "EPHX1", "EPHX2", "EPPK1", "EPRS", "EPS15", "EPS15L1", "ERAL1", "ERAP1", "ERCC2", "ERCC3", "ERGIC2", "ERGIC3", "ERH", "ERLIN1", "ERLIN2", "ERMP1", "ERO1A", "ERP29", "ERP44", "ESD", "ESF1", "ESYT1", "ESYT2", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXO1", "EXOC1", "EXOC2", "EXOC4", "EXOC5", "EXOC7", "EXOSC10", "EXOSC3", "EXOSC4", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC8", "EZR", "F11R", "FABP5", "FADS2", "FAF1", "FAF2", "FAHD1", "FAM162A", "FAM208A", "FAM3C", "FAM49B", "FAM8A1", "FAM91A1", "FAM98A", "FAM98B", "FANCI", "FAR1", "FARSA", "FARSB", "FASN", "FASTKD2", "FBL", "FBXO22", "FBXO7", "FDFT1", "FDX1", "FDXR", "FECH", "FEN1", "FERMT2", "FGFR1OP", "FH", "FHL1", "FHOD1", "FIP1L1", "FIS1", "FKBP10", "FKBP14", "FKBP1A", "FKBP4", "FKBP7", "FKBP8", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FMR1", "FNDC3A", "FNTB", "FOXC1", "FOXRED1", "FRYL", "FSCN1", "FTO", "FTSJ3", "FUCA1", "FUCA2", "FUNDC2", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GADD45GIP1", "GALNT2", "GALNT7", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GATAD2A", "GATAD2B", "GATB", "GATC", "GBA", "GBF1", "GCAT", "GCC2", "GCDH", "GCLM", "GCN1", "GDAP1", "GDI1", "GDI2", "GDPD1", "GEMIN4", "GEMIN5", "GET4", "GFM1", "GGA1", "GGCX", "GGH", "GHDC", "GHITM", "GIGYF2", "GINS2", "GINS3", "GINS4", "GLA", "GLB1", "GLDC", "GLG1", "GLMN", "GLOD4", "GLRX3", "GLRX5", "GLS", "GLUD1", "GLYR1", "GM2A", "GNA13", "GNAI1", "GNAI2", "GNAI3", "GNL2", "GNL3", "GNL3L", "GNS", "GOLGA3", "GOLGB1", "GOLIM4", "GOLPH3", "GOLT1B", "GORASP2", "GOT2", "GPAM", "GPATCH4", "GPD2", "GPHN", "GPI", "GPKOW", "GPR107", "GPR108", "GPR89B", "GPS1", "GPT2", "GPX8", "GRB2", "GRHPR", "GRPEL1", "GRSF1", "GRWD1", "GSK3A", "GSK3B", "GSR", "GSTK1", "GSTM3", "GSTZ1", "GTF2B", "GTF2E1", "GTF2F1", "GTF2F2", "GTF3C1", "GTF3C2", "GTF3C3", "GTPBP1", "GTPBP10", "GTPBP3", "GTPBP4", "GUSB", "GYG1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACD3", "HADH", "HADHA", "HADHB", "HAT1", "HAUS4", "HAUS5", "HCCS", "HCFC1", "HDAC2", "HDGF", "HDHD3", "HDHD5", "HDLBP", "HEATR1", "HELLS", "HEXA", "HEXB", "HGS", "HIBADH", "HIBCH", "HINT2", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HLTF", "HM13", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMGCL", "HMOX1", "HMOX2", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPM", "HNRNPR", "HNRNPU", "HOOK3", "HP1BP3", "HS2ST1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSDL1", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA14", "HSPA1B", "HSPA2", "HSPA4", "HSPA8", "HSPA9", "HSPB1", "HSPD1", "HSPE1", "HSPH1", "HTATSF1", "HTT", "HUS1", "HUWE1", "HYOU1", "IARS", "IARS2", "IBA57", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDI1", "IFIT5", "IFT27", "IGF2BP1", "IGF2BP3", "IGF2R", "IK", "IKBIP", "ILF2", "ILF3", "ILK", "ILVBL", "IMMT", "IMP3", "IMPDH1", "IMPDH2", "INA", "INF2", "INTS13", "INTS14", "INTS3", "INTS7", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "ISOC1", "IST1", "ITCH", "ITGB1", "IVD", "JUP", "KARS", "KAT7", "KCTD12", "KCTD5", "KDELC2", "KDELR1", "KDM1A", "KDM1B", "KDM3B", "KDSR", "KHDRBS1", "KIAA0319L", "KIAA0368", "KIAA1468", "KIF11", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF3A", "KIF4A", "KIF5B", "KIFBP", "KIFC1", "KLC1", "KLC2", "KLC4", "KNOP1", "KPNA1", "KPNA2", "KPNA3", "KPNA6", "KPNB1", "KRI1", "KTN1", "KYAT3", "L2HGDH", "LAMP1", "LAMP2", "LAMTOR1", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LAS1L", "LASP1", "LBR", "LDHA", "LDHB", "LDLR", "LEMD2", "LEMD3", "LETM1", "LGALS3", "LGALS3BP", "LGMN", "LIG1", "LIG3", "LIMA1", "LIPA", "LLGL1", "LMAN1", "LMAN2", "LMNA", "LMNB1", "LMNB2", "LNPEP", "LNPK", "LONP1", "LPCAT1", "LPP", "LRBA", "LRPAP1", "LRPPRC", "LRRC59", "LSM6", "LSM7", "LSM8", "LSS", "LTA4H", "LTV1", "LUC7L2", "LYAR", "LYPLA1", "M6PR", "MACF1", "MAD1L1", "MAD2L1", "MAGED2", "MAGT1", "MAIP1", "MAK16", "MAP1B", "MAP1S", "MAP2K1", "MAP2K2", "MAP4", "MAPK1", "MAPK14", "MAPRE1", "MAPRE2", "MARC1", "MARCKS", "MARS", "MARS2", "MASTL", "MAT2A", "MAT2B", "MATR3", "MAU2", "MAVS", "MBNL1", "MBOAT7", "MCAT", "MCCC1", "MCCC2", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCU", "MCUR1", "MDC1", "MDH1", "MDH2", "MDN1", "ME2", "MEAF6", "MECP2", "MED1", "MED24", "MESD", "METTL13", "MFAP1", "MFN1", "MFN2", "MGME1", "MGST2", "MGST3", "MIA2", "MIA3", "MICU1", "MICU2", "MID1", "MIF", "MIGA1", "MINPP1", "MIOS", "MIPEP", "MKI67", "MLEC", "MMAB", "MMS19", "MOGS", "MON2", "MORF4L1", "MOSPD2", "MOV10", "MPDU1", "MPHOSPH10", "MPP1", "MPP2", "MPP6", "MPRIP", "MPST", "MPV17L2", "MRC2", "MRE11", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL14", "MRPL15", "MRPL17", "MRPL19", "MRPL20", "MRPL21", "MRPL37", "MRPL38", "MRPL39", "MRPL40", "MRPL43", "MRPL44", "MRPL45", "MRPL47", "MRPL48", "MRPL49", "MRPL50", "MRPL53", "MRPL58", "MRPL9", "MRPS15", "MRPS17", "MRPS2", "MRPS22", "MRPS23", "MRPS25", "MRPS27", "MRPS30", "MRPS31", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRPS9", "MRTO4", "MSH2", "MSH3", "MSH6", "MSI1", "MSMO1", "MSN", "MSTO1", "MTA1", "MTA2", "MTBP", "MTCH1", "MTCH2", "MTDH", "MTFP1", "MTHFD1", "MTHFD1L", "MTHFD2", "MTOR", "MTPAP", "MTPN", "MTX1", "MTX2", "MUT", "MXRA7", "MYBBP1A", "MYCBP", "MYDGF", "MYEF2", "MYG1", "MYH10", "MYH14", "MYH9", "MYL6", "MYO1B", "MYO1D", "MYO6", "NAA10", "NAA15", "NAA25", "NAA35", "NAA40", "NAA50", "NADK2", "NAF1", "NAGLU", "NAMPT", "NAP1L1", "NAP1L4", "NAPA", "NAPG", "NASP", "NAT10", "NAXE", "NBN", "NCAPD2", "NCAPG", "NCAPH", "NCBP1", "NCBP2", "NCDN", "NCKAP1", "NCL", "NCLN", "NCOA5", "NCSTN", "NDC1", "NDUFA10", "NDUFA11", "NDUFA13", "NDUFA2", "NDUFA4", "NDUFA5", "NDUFA7", "NDUFA8", "NDUFA9", "NDUFAF4", "NDUFAF7", "NDUFB10", "NDUFB11", "NDUFB3", "NDUFB4", "NDUFB5", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS7", "NDUFS8", "NDUFV1", "NDUFV2", "NECAP2", "NEFL", "NEFM", "NEK9", "NELFA", "NELFCD", "NELFE", "NENF", "NES", "NFKB1", "NFS1", "NHLRC2", "NHP2", "NIFK", "NIP7", "NIPSNAP2", "NISCH", "NKRF", "NLE1", "NLN", "NMD3", "NME1", "NME2", "NMT1", "NNT", "NOC2L", "NOC3L", "NOC4L", "NOL10", "NOL11", "NOL6", "NOL7", "NOL8", "NOL9", "NOLC1", "NONO", "NOP10", "NOP14", "NOP16", "NOP2", "NOP56", "NOP58", "NOP9", "NOSIP", "NPC1", "NPLOC4", "NPM1", "NRBP1", "NRDC", "NSA2", "NSD2", "NSDHL", "NSF", "NSFL1C", "NSUN2", "NSUN5", "NUB1", "NUBP2", "NUBPL", "NUCB1", "NUCB2", "NUCKS1", "NUDC", "NUDCD2", "NUDT1", "NUDT21", "NUDT9", "NUFIP2", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP160", "NUP188", "NUP205", "NUP210", "NUP214", "NUP35", "NUP37", "NUP50", "NUP54", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NUTF2", "NVL", "NXF1", "OAT", "OCIAD1", "OCLN", "OGDH", "OGT", "OLA1", "OPA1", "OPA3", "OSBP", "OSBPL11", "OSBPL6", "OSBPL8", "OSBPL9", "OSGEP", "OXA1L", "P3H1", "P3H4", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PACSIN3", "PAF1", "PAFAH1B1", "PAFAH1B3", "PAK1", "PAK1IP1", "PAK2", "PALLD", "PARK7", "PARN", "PARP1", "PARP2", "PBRM1", "PC", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCID2", "PCK2", "PCLAF", "PCM1", "PCNA", "PCNP", "PCYOX1", "PDAP1", "PDCD11", "PDCD6", "PDCD6IP", "PDCL3", "PDE12", "PDE4DIP", "PDE6D", "PDHA1", "PDHB", "PDIA3", "PDIA4", "PDIA6", "PDK3", "PDLIM1", "PDLIM5", "PDLIM7", "PDS5A", "PDS5B", "PDXK", "PECR", "PEF1", "PELP1", "PES1", "PEX11G", "PEX14", "PEX19", "PEX5", "PFDN2", "PFDN4", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGK1", "PGM1", "PGM2", "PGRMC1", "PGRMC2", "PHB", "PHB2", "PHF5A", "PHF6", "PHF8", "PI4K2A", "PI4KB", "PICALM", "PIGK", "PIGS", "PIH1D1", "PIK3C3", "PIN1", "PIN4", "PINX1", "PIP4K2C", "PISD", "PITPNB", "PITRM1", "PKM", "PKMYT1", "PKN1", "PKN2", "PLA2G15", "PLAA", "PLBD2", "PLCG1", "PLD3", "PLD6", "PLEC", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLRG1", "PLS3", "PMPCA", "PMPCB", "PNN", "PNO1", "PNP", "PNPLA8", "PNPT1", "POFUT1", "POGZ", "POLA1", "POLA2", "POLD1", "POLDIP2", "POLDIP3", "POLE", "POLE3", "POLE4", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2A", "POLR2B", "POLR2C", "POLR2E", "POLR2G", "POLR2L", "POLR3A", "POLRMT", "PON2", "POP1", "POR", "PPA2", "PPAN", "PPFIA1", "PPIB", "PPID", "PPIE", "PPIF", "PPIH", "PPIL1", "PPOX", "PPP1CA", "PPP1CB", "PPP1R10", "PPP1R12A", "PPP1R7", "PPP1R8", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP4R3A", "PPP5C", "PPP6C", "PPT1", "PPT2", "PQBP1", "PRAF2", "PRC1", "PRCC", "PRCP", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PREPL", "PRIM1", "PRIM2", "PRKACA", "PRKAG1", "PRKAR1A", "PRKAR2A", "PRKCSH", "PRKDC", "PRKRA", "PRMT1", "PRMT5", "PRPF19", "PRPF3", "PRPF31", "PRPF38B", "PRPF39", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPS2", "PRPSAP1", "PRPSAP2", "PRRC1", "PRRC2C", "PSAP", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD6", "PSMD7", "PSMD8", "PSME1", "PSME2", "PSME3", "PSME4", "PSMF1", "PSMG1", "PSPC1", "PTBP1", "PTBP2", "PTCD1", "PTCD3", "PTDSS1", "PTGES2", "PTGES3", "PTK7", "PTPA", "PTPN1", "PTRH2", "PUM1", "PUM3", "PURA", "PWP1", "PWP2", "PXMP2", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QKI", "QRSL1", "RAB10", "RAB11B", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB1B", "RAB24", "RAB34", "RAB3GAP1", "RAB3GAP2", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RAB8A", "RAB8B", "RAB9A", "RABEP1", "RABEPK", "RABGAP1", "RAC1", "RACK1", "RAD21", "RAD23A", "RAD23B", "RAD50", "RAD9A", "RAE1", "RAI14", "RALA", "RALB", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP9", "RANGAP1", "RAP1GDS1", "RAPGEF2", "RARS", "RARS2", "RBBP5", "RBBP6", "RBM10", "RBM12", "RBM12B", "RBM14", "RBM17", "RBM19", "RBM22", "RBM25", "RBM27", "RBM28", "RBM3", "RBM34", "RBM39", "RBM4", "RBM42", "RBM4B", "RBM5", "RBM8A", "RBMX", "RBMXL1", "RBPMS", "RCC1", "RCC2", "RCL1", "RCN1", "RCN2", "RDH11", "RDH13", "RDH14", "RDX", "RECQL", "REEP5", "REPS1", "RER1", "RETSAT", "REXO2", "REXO4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RFX1", "RHEB", "RHOA", "RHOG", "RHOT1", "RIDA", "RIF1", "RINT1", "RIOX2", "RIPK1", "RMDN1", "RNASEH2A", "RNASET2", "RNF14", "RNF20", "RNF219", "RNF40", "RNPS1", "ROCK2", "RP2", "RPA1", "RPA2", "RPAP3", "RPF2", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPN1", "RPN2", "RPP30", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RRBP1", "RRM1", "RRM2", "RRP1", "RRP12", "RRP15", "RRP1B", "RRP8", "RRS1", "RSF1", "RSL1D1", "RSU1", "RTCB", "RTN2", "RTN3", "RTN4", "RTN4IP1", "RTRAF", "RUFY1", "RUVBL1", "RUVBL2", "S100A10", "S100A11", "S100A13", "SACM1L", "SAE1", "SAFB", "SAFB2", "SAMHD1", "SAMM50", "SAP130", "SAP18", "SAR1A", "SARNP", "SARS2", "SART1", "SART3", "SBDS", "SC5D", "SCAF1", "SCAMP1", "SCAMP2", "SCAMP3", "SCARB1", "SCARB2", "SCCPDH", "SCD", "SCFD1", "SCML2", "SCO1", "SCO2", "SCP2", "SCRIB", "SCRN1", "SDF4", "SDHA", "SDHB", "SEC11A", "SEC16A", "SEC22B", "SEC23A", "SEC23B", "SEC23IP", "SEC24A", "SEC24B", "SEC24C", "SEC31A", "SEC61A1", "SEC61B", "SEC62", "SEC63", "SEH1L", "SEL1L", "SENP3", "SEPHS1", "SEPT11", "SEPT2", "SEPT7", "SEPT9", "SERBP1", "SERPINB6", "SERPINH1", "SET", "SETD2", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFXN1", "SFXN4", "SGPL1", "SGTA", "SH3BGRL3", "SH3GL1", "SH3GLB1", "SHCBP1", "SHMT2", "SHOC2", "SHTN1", "SIGMAR1", "SIRT1", "SKIV2L2", "SKP1", "SKP2", "SLAIN1", "SLC16A1", "SLC19A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A17", "SLC25A20", "SLC25A22", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A33", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A4", "SLC29A1", "SLC2A1", "SLC33A1", "SLC35A4", "SLC35B2", "SLC3A2", "SLC7A1", "SLC9A3R1", "SLFN11", "SLIRP", "SLK", "SLTM", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCC1", "SMARCC2", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC6", "SMCHD1", "SMN1*", "SMNDC1", "SMPD4", "SMU1", "SNAP23", "SNAP29", "SND1", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPC", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNU13", "SNW1", "SNX1", "SNX12", "SNX17", "SNX2", "SNX27", "SNX3", "SNX5", "SNX6", "SNX9", "SOAT1", "SOD2", "SON", "SORD", "SORT1", "SPAG9", "SPART", "SPATA5L1", "SPC24", "SPC25", "SPCS2", "SPECC1L", "SPEN", "SPOUT1", "SPPL2A", "SPTAN1", "SPTBN1", "SPTBN2", "SPTLC1", "SPTLC2", "SQLE", "SQSTM1", "SREK1", "SRI", "SRP14", "SRP54", "SRP68", "SRP72", "SRP9", "SRPK1", "SRPRA", "SRPRB", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF3", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSNA1", "SSR1", "SSR4", "SSRP1", "STAG1", "STAG2", "STAM", "STAMBP", "STARD3", "STARD3NL", "STARD7", "STAT1", "STAT3", "STAU1", "STAU2", "STIP1", "STK4", "STMN1", "STOM", "STOML2", "STRAP", "STRBP", "STRN", "STT3A", "STUB1", "STX12", "STX18", "STX5", "STX7", "STXBP3", "STXBP4", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGP2", "SUGT1", "SUN1", "SUPT16H", "SUPT5H", "SUPT6H", "SUPV3L1", "SURF4", "SURF6", "SUZ12", "SV2A", "SYAP1", "SYMPK", "SYNCRIP", "SYNE2", "SYNGR2", "SYNJ2BP", "TACC3", "TAF15", "TAMM41", "TARDBP", "TARS2", "TBCA", "TBCC", "TBCD", "TBCE", "TBL3", "TBRG4", "TCEA1", "TCERG1", "TCOF1", "TCP1", "TDP2", "TDRKH", "TECR", "TELO2", "TERF2IP", "TEX10", "TEX264", "TFAM", "TFCP2", "TFG", "TFRC", "THOC1", "THOC2", "THOC3", "THOC6", "THOP1", "THRAP3", "THUMPD3", "TIA1", "TIAL1", "TIGAR", "TIMM10", "TIMM17A", "TIMM17B", "TIMM23", "TIMM44", "TIMM50", "TIMM8B", "TJP1", "TKT", "TLN1", "TMA16", "TMCO1", "TMED10", "TMED2", "TMED5", "TMED7", "TMED9", "TMEM109", "TMEM126A", "TMEM14C", "TMEM165", "TMEM192", "TMEM199", "TMEM201", "TMEM214", "TMEM230", "TMEM33", "TMEM43", "TMEM97", "TMOD1", "TMOD3", "TMPO", "TMPO", "TMTC3", "TMX1", "TMX2", "TMX3", "TMX4", "TNKS1BP1", "TNPO1", "TNPO3", "TOE1", "TOLLIP", "TOMM20", "TOMM22", "TOMM34", "TOMM40", "TOMM5", "TOMM70", "TOP1", "TOP2A", "TOP2B", "TOR1AIP1", "TOX4", "TP53", "TP53BP1", "TPD52", "TPM1", "TPM3", "TPM4", "TPP1", "TPP2", "TPR", "TPT1", "TPX2", "TRA2A", "TRA2B", "TRAM1", "TRAP1", "TRAPPC5", "TRIM21", "TRIM24", "TRIM25", "TRIM27", "TRIM28", "TRIP12", "TRIP13", "TRMT10C", "TROVE2", "TSFM", "TSG101", "TSN", "TSNAX", "TSPAN3", "TSPAN6", "TSR1", "TTC1", "TTC19", "TTC26", "TTC37", "TTF2", "TTLL12", "TTYH3", "TUBB", "TUBB2A", "TUBB2B", "TUBB4A", "TUBB4B", "TUBB6", "TUBGCP2", "TUBGCP3", "TUFM", "TWF1", "TWF2", "TXLNG", "TXNDC12", "TXNDC5", "TXNL1", "TXNRD1", "TYMS", "U2AF1", "U2AF2", "UBA1", "UBA2", "UBAP2", "UBAP2L", "UBE2G2", "UBE2K", "UBE2L3", "UBE2N", "UBE2O", "UBE2S", "UBE3A", "UBE4B", "UBLCP1", "UBQLN4", "UBR4", "UBR5", "UBTF", "UBXN1", "UCHL5", "UFD1", "UFL1", "UFM1", "UGGT1", "UHRF1", "UNC119", "UNC119B", "UNC45A", "UNG", "UPF1", "UQCC1", "UQCR10", "UQCRB", "UQCRC1", "UQCRC2", "UQCRQ", "URB1", "USMG5", "USO1", "USP10", "USP11", "USP14", "USP15", "USP39", "USP47", "USP48", "USP5", "USP7", "USP9X", "UTP11", "UTP14A", "UTP15", "UTP18", "UTP20", "UTP3", "UTP4", "UTP6", "UTRN", "VAMP7", "VANGL1", "VAPA", "VAPB", "VARS1", "VARS2", "VAT1", "VBP1", "VCL", "VCP", "VDAC1", "VDAC2", "VDAC3", "VIM", "VIPAS39", "VIRMA", "VKORC1L1", "VMP1", "VPS18", "VPS26A", "VPS29", "VPS33A", "VPS33B", "VPS35", "VPS4B", "VPS52", "VRK1", "VTA1", "VTI1B", "WAPL", "WASHC4", "WBP11", "WBP2", "WDHD1", "WDR1", "WDR18", "WDR3", "WDR36", "WDR41", "WDR43", "WDR46", "WDR5", "WDR61", "WDR75", "WDR77", "WDR82", "WDR91", "WFS1", "WIPI2", "WIZ", "WTAP", "XAB2", "XPNPEP3", "XPO1", "XPO5", "XPO7", "XPOT", "XRCC1", "XRCC5", "XRCC6", "XRN2", "YARS", "YARS2", "YBX1", "YBX3", "YEATS4", "YKT6", "YLPM1", "YME1L1", "YRDC", "YTHDC1", "YTHDC2", "YTHDF2", "YTHDF3", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2", "ZC3H14", "ZC3H18", "ZC3HC1", "ZCCHC8", "ZFR", "ZFYVE16", "ZMPSTE24", "ZMYM2", "ZNF207", "ZNF326", "ZNF622", "ZNF638", "ZPR1", "ZW10", "ZYX"], "leading_proteins": ["AARS2", "ABCB1", "ABCB7", "ABCD3", "ABHD10", "ACAD9", "ACAT2", "ACOT8", "ACOX1", "ACOX3", "ACP6", "ACSL4", "ADA", "ADD1", "ADPGK", "AHCYL1", "AKAP8", "AKAP8L", "AKT2", "ALDH3A2", "ALG1", "AMOT", "ANKLE2", "ANKRD50", "APC", "APOL2", "APOOL", "APP", "ARHGAP17", "ASNA1", "ATAD1", "ATAD3A", "ATAD3B", "ATP13A1", "ATP1A1", "ATP2A2", "ATP2B1", "ATP5B", "ATP5C1", "ATP5L", "ATP6V0A1", "ATP6V0A2", "AUP1", "B3GALT6", "BAIAP2", "BCAP31", "BCAS3", "BCL2L13", "BICD2", "BNIP1", "BRI3BP", "BSG", "C12orf73", "CALU", "CAMK2G", "CAPZA1", "CAPZB", "CASK", "CBX5", "CCDC47", "CDK4", "CERS1", "CERS2", "CHCHD3", "CHD4", "CHID1", "CHST14", "CISD1", "CKAP4", "CLCC1", "CLCN3", "CLN5", "CLPTM1", "CLTA", "COA3", "COA7", "COASY", "COPB2", "COPS5", "COPS6", "COPS7B", "COX15", "COX4I1", "COX7A2", "CPOX", "CPT2", "CRNKL1", "CSNK1A1", "CSTF1", "CTBP1", "CTSC", "CYB5B", "CYP51A1", "DAGLB", "DCTN3", "DCTPP1", "DERL1", "DHCR24", "DHCR7", "DNM1L", "DNM2", "DOLPP1", "DRG1", "DYNLL2", "EBP", "ECE1", "ECH1", "EIF2B2", "EIF2B3", "EIF3E", "EMD", "EPB41L3", "EPHX1", "ERCC3", "ERGIC2", "ERGIC3", "ERMP1", "FADS2", "FAM162A", "FAM8A1", "FDFT1", "FGFR1OP", "FKBP14", "FKBP1A", "FKBP7", "FMR1", "FOXRED1", "FUCA2", "FUNDC2", "GATAD2A", "GBA", "GDAP1", "GGCX", "GHDC", "GHITM", "GLG1", "GLUD1", "GOLIM4", "GOLPH3", "GOLT1B", "GPAM", "GPD2", "GPHN", "GPR107", "GPR108", "GPX8", "GRB2", "GTF2E1", "GUSB", "GYG1", "HACD3", "HADH", "HADHA", "HAUS5", "HDAC2", "HK2", "HLA-B", "HM13", "HMOX1", "HMOX2", "HNRNPA3", "HNRNPAB", "HNRNPH2", "HNRNPK", "HNRNPM", "HNRNPR", "HS2ST1", "HSD17B12", "HSDL1", "ICMT", "IFIT5", "IKBIP", "ILVBL", "IMMT", "INA", "IPO9", "ITCH", "KAT7", "KCTD12", "KDELR1", "KDSR", "KHDRBS1", "KIAA0319L", "KIFBP", "KLC2", "KYAT3", "LARP4", "LBR", "LETM1", "LMNA", "LNPEP", "LRRC59", "LSS", "LTA4H", "MAIP1", "MAP2K2", "MATR3", "MBOAT7", "MCCC2", "MCL1", "MCM2", "MCM3", "MCM5", "MCM6", "MCM7", "MCUR1", "MED1", "MED24", "MFN1", "MIA2", "MICU2", "MIGA1", "MIPEP", "MMAB", "MORF4L1", "MPP2", "MPV17L2", "MRPL20", "MRPL39", "MRPS9", "MSI1", "MSMO1", "MSTO1", "MTA1", "MTA2", "MTCH1", "MTDH", "MTFP1", "MTOR", "MTPN", "MTX1", "MTX2", "MXRA7", "MYH10", "MYH9", "MYL6", "MYO1D", "NAA10", "NAGLU", "NCLN", "NDC1", "NDUFA11", "NDUFA13", "NDUFAF7", "NDUFB10", "NDUFB11", "NDUFB3", "NDUFB4", "NDUFB5", "NDUFB9", "NDUFS2", "NEFL", "NEFM", "NIPSNAP2", "NNT", "NONO", "NPC1", "NRDC", "NSUN2", "NUCB1", "NUCB2", "NUP107", "NUP37", "NUP88", "NUP93", "OCIAD1", "OCLN", "OPA1", "OPA3", "OSBP", "OSBPL6", "OXA1L", "P3H1", "P3H4", "P4HA1", "PAK1", "PCID2", "PCM1", "PCYOX1", "PDE6D", "PDK3", "PECR", "PEX11G", "PEX14", "PEX19", "PEX5", "PFDN2", "PFDN4", "PFDN6", "PGRMC1", "PGRMC2", "PI4K2A", "PIGK", "PIK3C3", "PIP4K2C", "PITRM1", "PKM", "PKMYT1", "PLA2G15", "PLBD2", "PLD3", 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0.0644653504377217 0.0007398580731883 3.570101593625075e-05 +Alcohol binding 5 14 3.0123533251105634 0.0025923067713127 5.70873786407767 16.094660194174757 1.0972550148478282 0.1642412137618775 2.3364194162363723 2.1334758164294443 1.72577974721897 0.2306417307890987 0.0002772964264109 0.0017444833819259 0.0013677912764581 0.0012377122057681 0.0336187943157164 +Cholesterol binding 5 13 2.9479354580966493 0.0031990384693756 5.25 13.29126213592233 1.1679703080780182 0.1357521674166823 1.9454015982929531 1.7674569958716484 1.7544522374432017 0.2116991383290636 1.402202400369444e-05 0.0003865639533612 0.0001888015632795 6.929711507029932e-05 0.0028413691736374 +Endopeptidase activity 27 58 2.8952953630333256 0.0037880192217001 19.08495145631068 62.800970873786405 1.5604938505680932 0.2935756148549138 5.629332570724372 6.156865220927466 1.27979578418692 0.359984229645684 0.0323106797157328 1.0 0.218343387502979 0.0071073575953651 0.0004533585672425 +Organic anion transmembrane transporter activity 14 25 2.846709505520512 0.0044173651734014 12.951456310679612 30.182038834951456 1.56101282472555 0.2452312368187786 6.880574373146614 3.5222410835885483 1.575669523214114 0.314839840161206 0.0194120577699662 0.3371313972628795 0.0092927708056161 0.0551022953292233 0.0222235590899475 +Protein transporter activity 6 14 2.839622464861699 0.0045166954274376 6.053398058252427 14.696601941747574 1.6882240898296943 0.1359359142649309 2.957968193176 1.443999336657768 1.4805047019217734 0.2345897542974644 0.0010047562716394 0.0002227197090729 9.045443106927394e-05 0.0028478177309091 0.0001398373652982 +Inorganic molecular entity transmembrane transporter activity 22 60 2.7799181720849293 0.0054372597496357 28.058252427184467 75.9635922330097 1.5031303400189615 0.2894264293069549 11.721339963426631 9.38477049228959 2.153051736566399 0.3821536813265525 0.0049341709437695 0.0288713637898469 0.002457298231329 0.0343754094561286 0.00775992538362 +Organic acid transmembrane transporter activity 10 17 2.741691815473299 0.0061123660657269 8.592233009708737 21.276699029126213 1.5973629153049684 0.1905568538747131 4.4420473133518055 2.549726956007885 1.3213968531498468 0.2647933566957936 0.0078914427181116 0.2801168002074996 0.0042348756279302 0.0242455864981032 0.0468956043941571 +Lipid binding 26 125 2.712398805945819 0.0066798173386422 30.883495145631063 138.65533980582524 0.9844637598707308 0.4289871747751645 8.92748670410201 14.760635317682617 1.446857667744565 0.4068298387995807 0.0079749328397483 0.0052997906703188 0.0040865614495963 0.0063235077949935 0.0733059330460842 +Metalloexopeptidase activity 6 19 2.653728951287432 0.0079607744431065 5.395631067961165 20.067961165048544 0.9825976981990544 0.3457114951896768 2.1791777953827336 1.4039620491256346 0.996651753778752 0.2995335114577974 0.0003985074001634 0.0121686135974036 0.045127039841821 0.0001711644149485 3.2730608309419086e-05 +Oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen 9 28 2.6198197529742835 0.0087976253285551 9.395631067961164 29.8373786407767 1.5709767518568172 0.2393367467664754 3.119976403291062 3.762391942431812 1.2135099906711824 0.3124947384976632 0.0015182289711724 0.3624074851394556 0.0616304522136525 0.0004061287070796 0.0017912894842132 +Cation transmembrane transporter activity 15 55 2.5529616855437607 0.0106811245205014 25.62135922330097 70.51699029126213 1.766742880952279 0.2698419237572138 12.29126021871486 8.422243011776631 2.00238274385689 0.3706372466673562 0.0097530761502087 0.0990971562045587 0.0071352603932811 0.0545113112633792 0.059045110184499 +Oxidoreductase activity acting on the ch ch group of donors 12 26 2.5049202934854087 0.0122478991083814 7.567961165048544 28.033980582524272 0.602739632464327 0.3658961640745555 3.3714596992024415 2.798024733162656 1.2394975779858992 0.2994161584769358 2.699541647320076e-05 0.0230489069918226 0.0118453859760714 2.0229101637934145e-05 3.919573774442413e-07 +Macromolecule transmembrane transporter activity 5 12 2.4983634293842347 0.0124768207570535 4.820388349514563 12.281553398058252 1.6605285757306012 0.1306403746261988 2.4754663863133306 1.0160601209961664 1.3599823000893485 0.2280235038874096 0.0054180146544749 0.0001122733832082 0.0008978593047678 0.0011993766429203 0.0002808101441202 +Exopeptidase activity 11 31 2.4874522396258016 0.0128661727901526 9.74514563106796 31.84223300970874 1.193034763402526 0.2308543476384821 3.0338864063053523 1.9513159274241312 1.6646797512653713 0.2911825093455628 0.0008210075022433 0.0345877004093447 0.0212914346042941 0.000643303268372 5.72508037374203e-06 +Active transmembrane transporter activity 20 61 2.429806539910093 0.0151068840528763 26.354368932038835 73.12621359223301 1.313035419122872 0.3239574057550545 11.878456281473593 8.663537710607383 1.88741562841277 0.3851687956916088 0.0316715408865508 0.6257595800989444 0.0137108103615842 0.1177672982720232 0.0008433831285153 +Exogenous protein binding 2 14 2.3909157858198253 0.0168064073403533 4.509708737864078 15.157766990291265 0.7214109752050332 0.2527966464979699 2.499010078306418 1.9009100692398744 1.5211756979359785 0.2791170769282048 0.0484731576044697 0.0196403757049561 0.0705821305211966 0.0949405615621671 0.3768947236315802 +Metalloendopeptidase activity 9 14 2.339601104525624 0.0193043457358199 5.449029126213592 14.364077669902912 1.4597326207035937 0.2246869419023046 2.4848715129851016 0.6671711573432166 0.9390012824303952 0.2775881383017788 0.0218176291796623 1.0 0.0405463165390607 0.007920049564759 0.0008855678200528 +Protein transmembrane transporter activity 2 11 2.333171462293401 0.0196391479895368 4.37621359223301 11.264563106796116 1.6409152716253632 0.1284874270119089 2.3258190399954897 0.995332092405782 1.387057072324357 0.2266762256512647 0.0033641802428605 6.765318543664244e-05 0.0005470061355849 0.0074273483269255 0.0010238181908857 +Nucleobase containing compound transmembrane transporter activity 4 13 2.3057626266895 0.0211238995829985 6.529126213592233 14.04126213592233 1.4296604886183193 0.212054291115069 3.2696940585469636 1.915888183904924 1.3255809572534116 0.2748813593420038 0.1150909213426581 0.1430638950507344 0.0383266740374144 0.0415700360883472 0.0039931942773163 +Oxidoreductase activity acting on the ch ch group of donors nad or nadp as acceptor 6 13 2.259155578404149 0.0238737089377196 3.8398058252427183 12.78883495145631 0.8288316105774708 0.2715528044153261 1.786836430207192 1.277729935586139 1.1940635938633195 0.228034100916913 4.932428381188264e-05 0.0053672672920639 0.0206800818926893 1.3582842958771772e-05 7.764656577303177e-05 +Sphingolipid binding 3 5 2.251672786626628 0.0243429576110905 3.2305825242718447 6.810679611650485 1.3881601090528384 0.1287371848492678 1.3662849673921555 1.293404675510669 1.5116584105270494 0.2146285912590262 0.0002685530355483 0.0032958763634803 0.012905013470629 0.0007869115437374 0.0098879726868235 +Monooxygenase activity 5 8 2.233804591669083 0.025495933299843 4.043689320388349 8.322815533980583 1.6049222537693364 0.1501440468766332 1.612461779657682 1.2307404965531048 1.237349324058907 0.2369071661653372 0.0013548671993401 0.1221118561195742 0.0021930786590517 3.671693537728937e-05 0.0016034677277021 +O acyltransferase activity 3 9 2.1847339753272075 0.0289083575405957 4.711165048543689 12.395631067961164 0.9877600518928406 0.2684789023147002 2.6842893514436073 2.3496085895491885 1.2379749168209273 0.2720543739153138 0.0025859838572013 0.1430638950507344 0.0002440819573241 0.0070923684446229 0.0682397501835214 +Sulfur compound transmembrane transporter activity 3 5 2.183984898821667 0.0289633577384316 2.9635922330097086 6.752427184466019 1.4746434057995097 0.1672652154050841 1.7026919602194592 1.5538455059459366 1.0954441166028872 0.2266277553273111 0.001782236196207 0.1305522111527444 0.0027014769688677 0.0049571663496986 0.0504521665366165 +Fad binding 3 9 2.1820578440623266 0.0291052639220932 3.78883495145631 9.932038834951456 1.575439945642976 0.1698004033102896 1.8828741719818296 1.250336932628077 0.9196006746446306 0.2289411404885479 0.011407229128343 0.1178616319260966 0.0260710687649276 0.0033024410276518 0.0355737118947821 +Oxidoreductase activity 50 209 2.09984973559499 0.035742061549121 52.54126213592233 227.42961165048544 0.490492706528076 0.5955656171597654 20.033606385640603 16.688970744458114 1.2909283370539455 0.4039853598071011 1.3297493425271361e-07 0.007248627370529 0.0001907427957799 1.3905762554145242e-06 4.092848197237384e-09 +Active ion transmembrane transporter activity 15 32 2.097018720820216 0.0359919181565122 16.271844660194176 41.71116504854369 1.2957221273899948 0.3267733012969381 7.788084220174416 5.097264791179653 1.6571109350293016 0.3632481416270505 0.1689103086249734 1.0 0.3182249609881349 0.320496060053052 0.0287949721551627 +Quinone binding 2 5 2.0870741960481403 0.0368814281779277 2.0825242718446604 5.371359223300971 0.6144040024425256 0.3400691378536611 1.308295206174148 0.7946759106689059 1.1785397932704846 0.300626350021166 0.2129660379916928 0.0607401038440192 0.1191939669275513 0.2731207001200411 0.0228394808772788 +Inorganic anion transmembrane transporter activity 8 13 2.086435267733274 0.0369392131251833 7.427184466019417 19.274271844660195 1.0921593405593897 0.2441056926448881 3.717191605498929 3.7816647851785734 1.4014196343960104 0.2816216967014333 0.0146896731279065 0.0257535715284909 0.0139156518076104 0.0367529115341812 0.012512209523234 +Serine hydrolase activity 7 17 2.0523541997093337 0.0401352521768492 6.934466019417476 18.83009708737864 1.2767207242593377 0.1489147276149277 2.386872767465543 1.965791668457755 1.709796217367629 0.2208345231085202 0.2180602949864416 1.0 0.3746418042016168 0.1099245732268714 0.0081332818022798 +Mirna binding 9 14 2.0502578444881294 0.0403392759543548 5.356796116504855 13.716019417475728 0.2051470497500039 0.5875839080603199 2.9289942319606412 1.5748125731018472 0.8441668576388831 0.3077891504368221 1.0 1.0 1.0 0.1724444479617574 0.0005931675183369 +Vitamin transmembrane transporter activity 4 5 2.0446773468491526 0.0408866783898154 2.7766990291262137 6.252427184466019 1.4438342367310928 0.182339474606115 1.52603324115363 1.3650879028699858 1.0282691527982806 0.2346378729908682 0.2953957531356467 0.0875404472016038 0.1693528922958147 0.0762921742488627 0.0017743753624758 +Phosphatidylcholine binding 2 7 2.012951646090249 0.044119716515121 2.2524271844660193 7.929611650485437 1.2697801287388335 0.1567893034984199 1.081337239384838 1.04388968498945 1.4953842980517238 0.2256102823610289 0.0028078920333119 5.590323461425328e-05 0.000453663444764 0.0062267265321947 0.0401461367370898 +Molecular transducer activity 10 27 2.009135564493491 0.0445227588954344 10.91747572815534 33.40533980582524 1.343848990749489 0.2329582295822712 4.7124072380860955 5.830391636254363 1.6098335072319665 0.2956883791113679 0.1923328589070614 0.3530243184113045 0.4597588064413886 0.1746659339951793 0.7193316866684596 +Poly purine tract binding 11 16 2.0043372442988057 0.0450339467934315 5.558252427184466 15.1747572815534 -0.0276612113620522 0.6248740742975116 3.405307800747814 1.11195781565948 0.8182388849461438 0.3030179928613766 0.0755162513806922 1.0 1.0 0.0217985290060267 0.0312662716526952 +Proton transmembrane transporter activity 8 33 1.9658433270961555 0.0493167112073271 12.769417475728156 35.478155339805824 1.2352045534927034 0.2879171268332734 5.319202861157036 2.7149368379617917 1.7021108079122016 0.3308025072902738 0.0459926615299242 0.0490886173861251 0.0057249284475035 0.1044322137967542 0.0095202961329739 +Primary active transmembrane transporter activity 13 45 1.9608571030069537 0.0498956945904909 17.696601941747574 52.529126213592235 1.0080198242353189 0.3544097082146772 7.649017203625277 6.455721193615876 1.66885648871365 0.3767837436492733 0.0224358706521036 0.4409382257745535 0.0061659416968062 0.0712392362884186 0.0020598266302504 diff --git a/msigdb_gomf/metrics.json b/msigdb_gomf/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..04f1964b3c8453e1c140b48cf48a8f7ba562d681 --- /dev/null +++ b/msigdb_gomf/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2734, + "annotations_size": 1310, + "title": "Average number of proteins per term", + "value": 15.218320610687023 +} \ No newline at end of file diff --git a/msigdb_gomf/paths.json b/msigdb_gomf/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..0c62ea7dfb582acc2eda55df791096568c9ae741 --- /dev/null +++ b/msigdb_gomf/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/msigdb_gomf/fragment/C166/C166_val_log2fc"} \ No newline at end of file diff --git a/msigdb_gomf/result.tsv b/msigdb_gomf/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..7ddc83d41dfd192f73765f0b80902792add14678 --- /dev/null +++ b/msigdb_gomf/result.tsv @@ -0,0 +1,330 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Transporter activity 0.5532275232165569 4.7951908622114505 1.6252001817651518e-06 0.0021267492254208 0.0020333077664847 146 Q9HC07,Q9Y619,Q99595,Q9C0H2,Q8IXU6,O60830,Q9Y277,P21796,P13073,Q07820,O95168,Q9NS69,O75306,O15118,O75027,P45880,Q9H2D1,P41440,O96000,Q9Y6M9,Q9BSK2,P51790,Q7KZN9,O43674,Q9Y487,Q02978,P16615,Q93050,Q8WTV0,P11166,P28288,Q70HW3,Q8NE01,P38435,Q9UDW1,Q9UM00,O95202,Q6P4A7,Q8NBU5,O75964,Q96GC9,Q99797,Q9HD20,P12236,P30825,P51991,Q9UBX3,P22059,O15173,Q9P0J0,Q8TB61,P04062,P08195,P08183,O43676,Q9BZF3,Q13423,O14925,O96008,Q96S66,O43772,O43681 62 +Ion transmembrane transporter activity 0.5407048376943444 3.795226923747755 0.0001475084751003 0.1757244138396052 0.0030213026454097 82 Q9HC07,Q9Y619,Q9Y277,P13073,P21796,P45880,Q9H2D1,P41440,P51790,Q7KZN9,Q9Y487,Q02978,P16615,Q93050,P11166,Q70HW3,Q9UDW1,Q9UM00,O95202,Q6P4A7,O75964,Q9HD20,P12236,P30825,Q9UBX3,Q8TB61,P08195,Q13423,Q96S66,O43772,O43681 31 +Metallopeptidase activity 0.6168879221519815 3.380676145096977 0.0007230771221073 0.6123194703370693 0.0072815457745072 40 P36551,P09960,Q969V3,O75976,Q99797,P53582,O75844,Q5JRX3,Q9UIQ6,Q7L5N1,O43847,P42892,Q10713,Q7Z2K6,P55786 15 +Steroid binding 0.7467930977655788 3.2997265235735194 0.0009677908740177 0.7187242929027675 0.0090317618169025 21 O00264,Q14108,P21796,O15118,P22059,P45880,O15173,O95772,P04062,Q9BZF3 10 +Glycosphingolipid binding 0.9564421669106884 3.231978924777835 0.0012293612271316 0.8004027993728291 0.0107913963671584 2 Q9NZJ7 1 +Ganglioside binding 0.9564421669106884 3.231978924777835 0.0012293612271316 0.8004027993728291 0.0107913963671584 2 Q9NZJ7 1 +Manganese ion transmembrane transporter activity 0.9535139092240128 3.219041201932267 0.0012862000289131 0.8147421316137737 0.0110125623390599 2 Q9HD20 1 +Transition metal ion transmembrane transporter activity 0.9535139092240128 3.219041201932267 0.0012862000289131 0.8147421316137737 0.0110125623390599 2 Q9HD20 1 +Sphingosine n acyltransferase activity 0.95241581259151 3.21418440948899 0.0013081562906287 0.8200014714680802 0.011127822991712 2 Q96G23 1 +Anion transmembrane transporter activity 0.6100099803847258 3.199172054545286 0.001378228899669 0.8358090477000573 0.0114270877124463 36 Q9Y619,P11166,Q9Y277,P21796,P12236,P30825,Q96S66,Q9UBX3,P41440,Q9H2D1,P45880,Q8TB61,P51790,O43681,P08195,Q02978 16 +Tetrapyrrole binding 0.7898082871701091 3.181081541863957 0.0014672632455157 0.8539091158451971 0.0120132178226599 16 O00264,Q16850,Q9NRV9,Q6UW02,O15173,P09601,O43169,P30519,Q96EY8,Q8WUJ1,Q9H7Z7 11 +Succinate transmembrane transporter activity 0.9432650073206456 3.173601512007822 0.001505602424543 0.8610756095554134 0.0121002403444867 2 Q9UBX3 1 +Sulfate transmembrane transporter activity 0.9432650073206456 3.173601512007822 0.001505602424543 0.8610756095554134 0.0121002403444867 2 Q9UBX3 1 +Acyl coa oxidase activity 0.9399707174231352 3.15894353998777 0.0015834216270593 0.8745598214290982 0.0124956766954685 2 O15254 1 +Oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen reduced flavin or flavoprotein as one donor and incorporation of one atom of oxygen 0.9344802342606168 3.1344566453683047 0.0017217269368705 0.8953784958554427 0.0131898379374294 2 P30519 1 +Sulfotransferase activity 0.926427525622256 3.098413113137906 0.001945600110683 0.9220134401159872 0.0144814553692883 2 Q8NCH0 1 +Sterol binding 0.7725444642202932 3.084815052698571 0.0020367876456031 0.9308109579735748 0.0150745300324298 16 Q14108,P21796,O15118,P45880,O95772,Q9BZF3 6 +Peptidase activity 0.4467910936377104 3.046470451567246 0.0023154523620836 0.9520098591847154 0.0168513477462753 102 P09960,P36551,Q15005,Q7L5N1,P67812,Q7Z2K6,P55786,Q969V3,O14773,Q8TCT9,Q9UIQ6,Q99436,P42892,Q10713,P53582,Q86TI2,P53634,P49721,Q99797,O43847,Q96K76,P28070,Q92643,P42785,O75976,P20618,O75844,Q5JRX3,Q92905,P28072 30 +Alcohol binding 0.8039493733606616 3.0123533251105634 0.0025923067713127 0.9666377790275986 0.0186589113759322 14 Q14108,P21796,O15118,P45880,Q9BZF3 5 +Folic acid transmembrane transporter activity 0.9004392386530068 2.981028510732948 0.0028728204542676 0.976920510341639 0.019299460487644 2 Q9H2D1 1 +Modified amino acid transmembrane transporter activity 0.9004392386530068 2.981028510732948 0.0028728204542676 0.976920510341639 0.019299460487644 2 Q9H2D1 1 +Phospholipase d activity 0.8986090775988307 2.972700221058076 0.002951926083174 0.9791987460785216 0.0195166893367934 2 P09601 1 +Cholesterol binding 0.8163632961462798 2.9479354580966493 0.0031990384693756 0.984966254353748 0.0208494547009058 13 Q14108,P21796,O15118,P45880,Q9BZF3 5 +Vitamin d binding 0.8850658857979518 2.9108154048468537 0.0036048692381946 0.9911815661455892 0.0222055886739537 2 P04062 1 +Endopeptidase activity 0.5162032577982522 2.8952953630333256 0.0037880192217001 0.993068836846322 0.0231023054512992 58 Q96TA2,P67812,Q9BYT8,O14773,Q8TCT9,Q99436,P42892,Q10713,Q5TDH0,P53634,Q99797,P49721,P48147,O43847,Q96K76,P28070,P60900,P49720,Q92643,P22695,P20618,O75844,Q5JRX3,Q92905,Q8TCT8,P28072,P28074 27 +Intramembrane lipid transporter activity 0.8806734992679404 2.8906474919802503 0.0038444908295565 0.9935649060785536 0.0232086773581522 2 P08183 1 +Organic anion transmembrane transporter activity 0.6424982786148506 2.846709505520512 0.0044173651734014 0.9969711347417564 0.0260664341313326 25 P53985,Q9Y619,P11166,P12236,P30825,Q9UBX3,P41440,Q9H2D1,Q8TB61,P08195,P53007,Q9H9B4,P05141,Q02978 14 +Protein transporter activity 0.7715731525459639 2.839622464861699 0.0045166954274376 0.9973422456302368 0.0264146027229609 14 Q99595,O60830,Q8NBU5,O14925,Q9HD20,Q9NS69 6 +Inorganic molecular entity transmembrane transporter activity 0.5001405435037105 2.7799181720849293 0.0054372597496357 0.9992090256648022 0.0304393601368495 60 Q9HC07,Q9Y277,P13073,P21796,P45880,P51790,Q7KZN9,Q9Y487,Q02978,P16615,Q93050,Q9UDW1,Q9UM00,O95202,Q99797,O75964,Q9HD20,Q9UBX3,P08195,Q13423,Q96S66,O43681 22 +Heme transmembrane transporter activity 0.8550512445095204 2.77204278227002 0.005570571468298 0.9993364125440238 0.0309020513184497 2 O15173 1 +Solute proton antiporter activity 0.8521229868228412 2.7583829845462104 0.0058088097839967 0.999515177622931 0.0315748581619742 2 O95202 1 +Organic acid transmembrane transporter activity 0.6912801382150575 2.741691815473299 0.0061123660657269 0.9996750278890982 0.0326824471269482 17 P53985,Q9Y619,P30825,Q9UBX3,P41440,Q9H2D1,Q9H9B4,P08195,Q02978,P08183 10 +Sulfatide binding 0.8469985358711594 2.734426164673812 0.0062489108394341 0.999728556698504 0.0331419967597518 2 P50897 1 +Lysophosphatidic acid binding 0.8469985358711594 2.734426164673812 0.0062489108394341 0.999728556698504 0.0331419967597518 2 P50897 1 +Lipid binding 0.413298217733105 2.712398805945819 0.0066798173386422 0.9998462092418324 0.0348627916877342 125 O00264,A6NIH7,P50897,Q9BQE5,P21796,O15118,P45880,O95772,Q8WTV0,Q14108,Q15067,Q13432,P38435,Q9NQZ5,O15254,Q9H6U6,P22059,O15173,P28070,Q9H4A6,P04062,O60313,Q9BZF3,Q8NCC3,Q9NZJ7,P07602 26 +Metalloexopeptidase activity 0.661734690254945 2.653728951287432 0.0079607744431065 0.9999716347589468 0.0387680837192175 19 P09960,Q7Z2K6,O75844,Q9UIQ6,P53582,P55786 6 +Aromatic amino acid transmembrane transporter activity 0.8268667642752645 2.6396639970214424 0.0082988260271834 0.9999818496991216 0.0392471555798238 2 P30825 1 +Cation cation antiporter activity 0.8268667642752583 2.6396639970214153 0.0082988260271841 0.9999818496991216 0.0392471555798238 2 O95202 1 +Calcium cation antiporter activity 0.8268667642752583 2.6396639970214153 0.0082988260271841 0.9999818496991216 0.0392471555798238 2 O95202 1 +Phosphatidylinositol phosphate phosphatase activity 0.8265007320644241 2.6379314751944887 0.0083413435365693 0.9999828410157218 0.0393063310536181 2 Q10713 1 +Oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen 0.5914523660196218 2.6198197529742835 0.0087976253285551 0.9999906101789268 0.0408558011784599 28 Q15800,Q32P28,Q16850,P16435,Q6UW02,P09601,P30519,O00767,Q14534 9 +Oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen nad p h as one donor and incorporation of one atom of oxygen 0.9183449285975832 2.5855883195264022 0.0097212963655497 0.9999972314925544 0.0436988946863885 3 Q16850,Q14534 2 +L ornithine transmembrane transporter activity 0.8125915080527177 2.5718411069399636 0.0101159307433971 0.9999983576004704 0.0449215907588143 2 P30825 1 +Volume sensitive anion channel activity 0.8114934114202057 2.566602284465645 0.0102700330984515 0.9999986606220016 0.045451835672201 2 P51790 1 +Cation transmembrane transporter activity 0.4885448455995983 2.5529616855437607 0.0106811245205014 0.9999992227751424 0.0466409104061894 55 Q9HC07,Q93050,O95202,P13073,Q70HW3,O75964,Q13423,Q9HD20,P30825,O43772,Q9UDW1,P51790,Q9Y487,P16615,Q9UM00 15 +Peroxisome targeting sequence binding 0.8052708638360166 2.536857010110104 0.0111852629758999 0.9999996013802406 0.0485188559550626 2 P50542 1 +Oxidoreductase activity acting on the ch ch group of donors 0.5884942213014739 2.5049202934854087 0.0122478991083814 0.9999999025391226 0.0514254738204476 26 P36551,Q15392,Q9H845,Q15067,O15254,Q9UBM7,P21912,Q8N4Q0,Q14739,Q9BY49,P30043,Q9H7Z7 12 +Macromolecule transmembrane transporter activity 0.7683094630116681 2.4983634293842347 0.0124768207570535 0.9999999280616172 0.0522192817627482 12 Q99595,O60830,O14925,Q9NS69,P51991 5 +Exopeptidase activity 0.5537865372727466 2.4874522396258016 0.0128661727901526 0.9999999570853728 0.0535069408098412 31 P36551,P09960,Q969V3,P53634,P42785,P53582,O75844,Q9UIQ6,Q7Z2K6,Q86TI2,P55786 11 +Xenobiotic transmembrane transporter activity 0.8949102892713292 2.4856506276067174 0.0129314848982395 0.9999999606484314 0.0536083709389046 3 P41440,P08183 2 +High density lipoprotein particle binding 0.8911503291867586 2.469510991224376 0.0135297862115495 0.9999999822168352 0.0557359117519808 3 Q9BQE5 1 +Guanylate kinase activity 0.882094470889784 2.4305191287195687 0.0150772101609419 0.9999999977256128 0.0614202916701597 3 O14936,Q14168 2 +Active transmembrane transporter activity 0.4645436774788353 2.429806539910093 0.0151068840528763 0.9999999978136308 0.0614202916701597 61 P13073,O95168,O75306,O75027,P41440,O96000,Q9Y6M9,P51790,Q7KZN9,Q02978,P16615,P28288,Q9UDW1,O95202,Q9HD20,P12236,Q9P0J0,Q9UBX3,P08183,O43676 20 +Exogenous protein binding 0.6905412044859436 2.3909157858198253 0.0168064073403533 0.999999999772416 0.0665147843379542 14 Q8WTV0,Q14108 2 +Metalloendopeptidase activity 0.681544696125363 2.3396011045256233 0.0193043457358199 0.9999999999918742 0.0740968452455678 14 P22695,Q99797,O75844,Q5JRX3,Q92905,O43847,P42892,Q96TA2,Q10713 9 +Ceramide binding 0.9571428571428572 2.3353511653068795 0.019525083327134 0.9999999999939494 0.0745710179549436 4 P21796,P45880,Q9NZJ7 3 +Protein transmembrane transporter activity 0.7724173538236173 2.333171462293401 0.0196391479895368 0.9999999999948048 0.0745718372936035 11 Q99595,O60830 2 +Acetylgalactosaminyltransferase activity 0.7591508052708605 2.3132802006733013 0.0207072385466622 0.9999999999987542 0.0774355932788196 2 Q86SF2 1 +Polypeptide n acetylgalactosaminyltransferase activity 0.7591508052708605 2.3132802006733013 0.0207072385466622 0.9999999999987542 0.0774355932788196 2 Q86SF2 1 +Amide transmembrane transporter activity 0.8546835340925932 2.311466141766941 0.0208071212474385 0.99999999999891 0.0774355932788196 3 Q9H2D1 1 +Nucleobase containing compound transmembrane transporter activity 0.6958532691652817 2.3057626266895 0.0211238995829985 0.9999999999992866 0.0783918086507877 13 P41440,Q9H2D1,Q8TB61,P51991 4 +Oxidoreductase activity acting on a sulfur group of donors disulfide as acceptor 0.7569546120058539 2.3024970875586654 0.021307155479036 0.9999999999994418 0.0787859298878466 2 Q8IXB1 1 +Dynein light chain binding 0.7536603221083461 2.2862992485961224 0.0222367578174713 0.9999999999998392 0.0808639518155663 2 Q13409 1 +Oxidoreductase activity acting on the ch ch group of donors nad or nadp as acceptor 0.687456563186263 2.259155578404149 0.0238737089377196 0.999999999999982 0.0857897896378623 13 Q15392,Q9UBM7,Q14739,Q8N4Q0,Q9BY49,Q9H7Z7 6 +Sphingolipid binding 0.9375821118782656 2.251672786626628 0.0243429576110905 0.9999999999999905 0.0871291652200234 5 P21796,P45880,Q9NZJ7 3 +Monooxygenase activity 0.8357626908638672 2.233804591669083 0.025495933299843 0.999999999999998 0.0900260717595534 8 Q16850,Q6UW02,P09601,P30519,Q14534 5 +Structural constituent of eye lens 0.8341266935188577 2.2211704936235144 0.0263394158811036 0.9999999999999992 0.0922583818295342 3 P36551,P08670 2 +Solute cation antiporter activity 0.8271695349688759 2.1904163266179073 0.0284940570201168 1.0 0.0977152217182018 3 O95202,P51790 2 +O acyltransferase activity 0.7979297646811572 2.1847339753272075 0.0289083575405957 1.0 0.0987718463972113 9 Q9HCL2,Q96N66,P23786 3 +Sulfur compound transmembrane transporter activity 0.9206051652366416 2.183984898821667 0.0289633577384316 1.0 0.0987718463972113 5 Q8TB61,Q9UBX3,Q70HW3 3 +Fad binding 0.7973600347956095 2.1820578440623266 0.0291052639220932 1.0 0.0987769319635806 9 O15254,Q15392,Q15067 3 +Prenyltransferase activity 0.823763288363307 2.175323277305828 0.0296058993801957 1.0 0.0994756537113857 3 P37268 1 +Organic cation transmembrane transporter activity 0.9167463904023424 2.175193351803083 0.0296156301743582 1.0 0.0994756537113857 4 Q70HW3 1 +Oxidoreductase activity acting on paired donors with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water 0.8235078725741485 2.174190588582818 0.0296908248863754 1.0 0.0994756537113857 3 O75845,O00767 2 +Aspartic endopeptidase activity intramembrane cleaving 0.8203992893503407 2.160394469170546 0.0307421452517853 1.0 0.101768236332244 3 Q8TCT9 1 +Inositol phosphate phosphatase activity 0.724011713030755 2.1392771221017775 0.0324132314040943 1.0 0.1053631095269568 2 Q10713 1 +Oxidoreductase activity 0.3464141484089385 2.09984973559499 0.035742061549121 1.0 0.1131175065084787 209 P36551,Q32P28,Q16850,Q9H845,P13073,O95168,P14406,P21912,Q8N0U8,Q8TED1,O75306,O75845,Q9BY49,Q9Y6M9,O96000,O43169,P51648,Q15392,Q15067,Q99536,Q06136,Q8N4Q0,Q8IUF8,P16435,P00367,Q13363,Q8NBX0,P09601,P30043,Q3SXM5,Q9UDW1,Q14534,O15254,P43304,Q6UW02,Q53GQ0,O00625,P30519,P40939,O43676,Q15800,Q9UBM7,Q14739,Q13423,Q9UHG3,P31350,O00767,Q16836,Q8WWV3,Q9H7Z7 50 +Active ion transmembrane transporter activity 0.4997337849307872 2.097018720820216 0.0359919181565122 1.0 0.1131175065084787 32 O95202,P13073,Q9HD20,P12236,P41440,P06576,P05023,P51790,Q7KZN9,P31930,P53007,P08195,Q02978,P16615,Q9UDW1 15 +Quinone binding 0.8965069366427759 2.0870741960481403 0.0368814281779277 1.0 0.1149414945225419 5 P21912,O75306 2 +Inorganic anion transmembrane transporter activity 0.6567205038292249 2.086435267733274 0.0369392131251833 1.0 0.1149414945225419 13 Q9Y277,P21796,Q96S66,Q9UBX3,P45880,P51790,O43681,Q02978 8 +Serine hydrolase activity 0.5820742940892357 2.0523541997093337 0.0401352521768492 1.0 0.1240027838482841 17 P42785,P53634,O75976,O14773,Q5JRX3,P67812,Q86TI2 7 +Mirna binding 0.631785601349913 2.0502578444881294 0.0403392759543548 1.0 0.1243398858828348 14 P22626,P98175,P67809,Q06787,Q14671,P43243,P09651,Q9BWF3,Q5T280 9 +Vitamin transmembrane transporter activity 0.8860388420666927 2.0446773468491526 0.0408866783898154 1.0 0.1254368821795273 5 P11166,Q9H2D1,P41440,P04062 4 +1 phosphatidylinositol 4 kinase activity 0.7020497803806717 2.0289569761780535 0.0424626726665642 1.0 0.1287641231324054 2 Q9UBF8 1 +Oxidoreductase activity acting on nad p h heme protein as acceptor 0.7888825687391654 2.0194354357912223 0.0434419815749986 1.0 0.1305252198698354 3 P16435 1 +Phosphatidylcholine binding 0.8124595916965863 2.012951646090249 0.044119716515121 1.0 0.1322581890956717 7 P21796,P45880 2 +Molecular transducer activity 0.5177810676726822 2.009135564493491 0.0445227588954344 1.0 0.1325097509056476 27 Q8WTV0,Q9BUN8,Q14108,Q99720,O15118,Q9Y6I9,Q15629,O15173,Q4VCS5,Q99442 10 +Poly purine tract binding 0.5917467410143308 2.0043372442988057 0.0450339467934315 1.0 0.1331703618496508 16 Q71RC2,Q9UNP9,Q96EP5,Q93062,O14979,Q07666,Q13310,O00571,Q06787,Q8TCS8,P31483 11 +Wide pore channel activity 0.8681318681318687 1.978886611067617 0.0478287740355178 1.0 0.1391486373786135 4 P21796,P45880,Q9Y277 3 +Porin activity 0.8681318681318687 1.978886611067617 0.0478287740355178 1.0 0.1391486373786135 4 P21796,P45880,Q9Y277 3 +Sodium ion transmembrane transporter activity 0.7797454070623608 1.9782069006349063 0.0479053705784386 1.0 0.1391486373786135 3 P08195 1 +Proton transmembrane transporter activity 0.4790173348978701 1.9658433270961555 0.0493167112073271 1.0 0.1427209088374786 33 Q93050,O95202,P13073,O75964,Q13423,P51790,Q9Y487,Q9UDW1 8 +Primary active transmembrane transporter activity 0.4418995011047436 1.9608571030069537 0.0498956945904909 1.0 0.1436557360737211 45 P28288,P13073,O95168,Q9HD20,O75306,O75027,O96000,Q9Y6M9,P08183,Q7KZN9,P16615,O43676,Q9UDW1 13 +Dipeptidyl peptidase activity 0.8615486155615174 1.9520129104086723 0.0509366718403925 1.0 0.1460110286890901 4 P42785,Q86TI2 2 +Mrna 3 utr binding 0.4331825469212103 1.939354905270684 0.0524581375336468 1.0 0.1490675925576514 50 Q9Y6M1,Q92945,Q71RC2,P35637,Q14103,Q13151,O95453,Q96EP5,P22626,P17844,Q13310,Q06787,Q92804,Q9BWF3,Q01085,Q14671,Q15287,P07910,Q12906,P31483 20 +P type transmembrane transporter activity 0.7701146404107877 1.9345797575686705 0.0530418860253278 1.0 0.1504001530155401 3 P16615 1 +Anion channel activity 0.7448189721830607 1.931977251490267 0.0533623137259957 1.0 0.1506565322867552 9 Q9Y277,P21796,Q96S66,P45880,P51790 5 +Dicarboxylic acid transmembrane transporter activity 0.7895743409629195 1.910849994005348 0.0560238608654475 1.0 0.1555353972135367 7 Q02978,Q9UBX3 2 +Neutral amino acid transmembrane transporter activity 0.7635150268306057 1.9045839690762132 0.0568341720678868 1.0 0.155902129881204 3 P08195 1 +Nucleotide transmembrane transporter activity 0.6887289702843014 1.904392923473019 0.0568590301438967 1.0 0.155902129881204 11 P41440,Q9H2D1,Q8TB61,Q9BSK2 4 +Organophosphate ester transmembrane transporter activity 0.6887289702843014 1.904392923473019 0.0568590301438967 1.0 0.155902129881204 11 P41440,Q9H2D1,Q8TB61,Q9BSK2 4 +Oxidoreductase activity acting on the ch ch group of donors oxygen as acceptor 0.8498718984240579 1.9041824542232753 0.0568864260177217 1.0 0.155902129881204 4 O15254,Q15067 2 +Metalloaminopeptidase activity 0.6877758281880108 1.8993975913841457 0.0575122199510764 1.0 0.1566341125486698 11 P09960,Q9UIQ6,P55786 3 +Regulatory rna binding 0.5567280663253522 1.8844784017120195 0.0595002936105746 1.0 0.1610441831195305 17 P22626,P98175,P67809,Q06787,Q14671,P43243,P09651,Q9BWF3,Q5T280 9 +Voltage gated anion channel activity 0.8449097238682708 1.8763948047800527 0.0606010874382803 1.0 0.1625060861880499 5 P21796,P45880,Q9Y277 3 +Glycolipid binding 0.8053769834177071 1.8750594373113172 0.0607845470435688 1.0 0.1625060861880499 6 P07602,Q9NZJ7,O14773,P50897 4 +Secondary active transmembrane transporter activity 0.5705755701157889 1.8687246174009131 0.0616611372518323 1.0 0.1638460239348891 16 P53985,O95202,P12236,Q9UBX3,P41440,P51790,P53007,P08195,Q02978 9 +C4 dicarboxylate transmembrane transporter activity 0.8036561359269788 1.867584347873471 0.0618200297939144 1.0 0.163935706538518 6 Q9UBX3 1 +Lys63 specific deubiquitinase activity 0.6687408491947296 1.859446603335112 0.0629638612621752 1.0 0.1656278278181718 2 O95630 1 +Protein lipid complex binding 0.8391327302350677 1.8525469196806263 0.0639473265568217 1.0 0.1675377081433717 5 Q9BQE5 1 +Nadplus binding 0.8389199327471213 1.8516675150190889 0.06407358151132 1.0 0.1675377081433717 5 P00367,Q16836 2 +Voltage gated channel activity 0.7521603621780033 1.850146911539026 0.0642923781452919 1.0 0.1677749310165986 8 P21796,P45880,Q9Y277 3 +Antiporter activity 0.7253351382021533 1.8376297700989797 0.0661169789536459 1.0 0.1715113711470816 9 O95202,P12236,Q9UBX3,P41440,P51790,Q02978 6 +Quaternary ammonium group binding 0.6961422463470974 1.8137867950791389 0.0697105562599174 1.0 0.1795220009848369 10 P21796,P45880 2 +Acylglycerol o acyltransferase activity 0.8261052042356191 1.8061983299539752 0.0708873657068769 1.0 0.1806662433385384 4 Q96N66 1 +Aminopeptidase activity 0.5881779378443814 1.7890712536682332 0.0736033410145062 1.0 0.186229406113106 14 P09960,P53582,Q9UIQ6,P55786 4 +Protease binding 0.5081867728828683 1.784861968330684 0.0742837088529675 1.0 0.1874983788003612 23 P46379,Q9BUN8,Q9NZJ7,P07602 4 +Map kinase activity 0.650805270863837 1.767149974070075 0.077203115090187 1.0 0.1926401538440858 2 P28482 1 +Single stranded rna binding 0.4372491418455058 1.7599605715712423 0.0784144920043696 1.0 0.1945511070562959 39 Q71RC2,O43347,Q96EP5,Q93062,O14979,P52597,P23588,Q13310,Q07666,O00571,P07910,P31943,Q13325,P09651,Q12906,P31483 16 +Lipopolysaccharide binding 0.777705335924294 1.7542584911901435 0.0793862248232839 1.0 0.1963928324006278 6 Q8WTV0 1 +Nedd8 specific protease activity 0.7286708165507142 1.7449333765656374 0.0809964667082461 1.0 0.1986991973554352 3 Q92905,Q9BT78 2 +Poly a binding 0.5960260186137406 1.735774643594948 0.0826036892264008 1.0 0.2011353771126116 13 Q71RC2,Q93062,O14979,Q07666,P31483 5 +Poly pyrimidine tract binding 0.5761391024663876 1.7157630336451284 0.0862054225787454 1.0 0.2091279695891786 14 O43347,Q96EP5,Q07666,Q13310,P31943,Q06787,Q13325,P07910 8 +Gated channel activity 0.6765942728025309 1.7142079355301951 0.08649054400764 1.0 0.2094318163586107 10 P21796,P45880,Q9Y277,P51790 4 +Scavenger receptor activity 0.8013497429362606 1.7032890800095082 0.0885139831545864 1.0 0.2129411218717494 4 Q8WTV0 1 +Cullin family protein binding 0.7630986820463765 1.6899983421797324 0.0910282718070947 1.0 0.2176040804147702 6 Q9BTE7,Q92564 2 +Lipid transporter activity 0.5428724201221066 1.6884667885003175 0.0913216590763863 1.0 0.2179077839527615 16 P11166,Q96GC9,O15118,P22059,P08183,Q9BZF3 6 +Threonine type endopeptidase activity 0.7166008400392367 1.682614586666947 0.0924497260690775 1.0 0.2193264667017356 8 Q99436,P28070,P28072,P49721 4 +Threonine type peptidase activity 0.7166008400392367 1.682614586666947 0.0924497260690775 1.0 0.2193264667017356 8 Q99436,P28070,P28072,P49721 4 +Acyltransferase activity 0.4118479151398963 1.6675858446964589 0.0953979701774001 1.0 0.2249501794511214 46 Q8NCC3,Q96G23,Q9HCL2,P27544,Q96N66,O95260,P23786 7 +Passive transmembrane transporter activity 0.4726504139826257 1.6477340193015786 0.0994072638499523 1.0 0.2329579886286897 27 Q9Y277,Q99797,P21796,O75964,O96008,Q96S66,P45880,P51790,Q9UM00 9 +Hydrolase activity acting on ether bonds 0.7284464200283626 1.633429845551985 0.1023786242487525 1.0 0.2373059983662357 7 P09960,P07099 2 +Zinc ion binding 0.3421957252362311 1.62478219626929 0.1042089759083348 1.0 0.2396202089426134 118 P09960,P36551,Q99640,P14373,P53004,Q969S3,Q15637,Q9BQ04,P55786,O43823,Q99536,Q99707,Q8N4Q0,Q9UIQ6,P42892,P00813,O95487,Q5JTZ9,Q12899,Q9BWF3,Q8NCC3,O75976,O75312,O95071,Q5JRX3,P49356,P43243,P62072,Q8WWV3 29 +H4 histone acetyltransferase activity 0.7026730135481508 1.6245324138806123 0.1042622283185417 1.0 0.2396202089426134 3 Q86UY6,O14929 2 +Phosphatidylcholine transfer activity 0.6226207906295791 1.6208314828892088 0.1050537845435699 1.0 0.2401753189390517 2 P48739 1 +Phosphatidylinositol transfer activity 0.6226207906295791 1.6208314828892088 0.1050537845435699 1.0 0.2401753189390517 2 P48739 1 +Phospholipid transfer activity 0.6226207906295791 1.6208314828892088 0.1050537845435699 1.0 0.2401753189390517 2 P48739 1 +Lamin binding 0.7250714687763898 1.6179312516029754 0.1056774143767791 1.0 0.2411801617309767 7 Q9ULX6,Q5SNT2,Q14739 3 +Ether hydrolase activity 0.7815613339628852 1.6122997636871816 0.1068967247268912 1.0 0.2431158149170617 5 P09960 1 +Epoxide hydrolase activity 0.7815613339628852 1.6122997636871816 0.1068967247268912 1.0 0.2431158149170617 5 P09960 1 +Amyloid beta binding 0.6563101671885121 1.6099863441811326 0.1074008375244348 1.0 0.2438389898735002 10 O00264,Q8WTV0 2 +Membrane insertase activity 0.7430754755209914 1.601397758514742 0.1092888488940868 1.0 0.246417198022812 6 Q15070 1 +Snap receptor activity 0.6295646290154806 1.589905033305333 0.1118562129470785 1.0 0.2504814341208085 11 O15400,Q9P2W9,Q86Y82,P51809,Q13190,Q9UEU0 6 +Abc type transporter activity 0.772491226434449 1.5740617092385027 0.1154731837716736 1.0 0.2552465166363328 5 Q9HD20,P08183,O75027 3 +Cargo receptor activity 0.6929421477860478 1.5698876854836652 0.1164412429978543 1.0 0.2554546519229906 8 Q8WTV0 1 +Sterol transporter activity 0.7120427527986969 1.5579426638705511 0.1192468404067721 1.0 0.2599310938606181 7 O15118,Q9BZF3 2 +Solute cation symporter activity 0.6870305919328904 1.5516337951261248 0.1207498720430493 1.0 0.2614584006221399 3 O00400 1 +Solute proton symporter activity 0.6870305919328904 1.5516337951261248 0.1207498720430493 1.0 0.2614584006221399 3 O00400 1 +Collagen binding 0.6394798004005545 1.522877849171376 0.1277892685370356 1.0 0.269571564868787 10 Q32P28,Q92791,Q9UBG0,Q53GQ0,Q13153 5 +L amino acid transmembrane transporter activity 0.6789080589687403 1.5025991980368558 0.132942430327126 1.0 0.275997755512734 8 Q9Y619,P08195,P30825,Q9H9B4 4 +Peptide binding 0.3781998531151248 1.461095586895571 0.1439892111603595 1.0 0.2961159601570974 61 O00264,Q8WTV0,Q15392,P24390,Q9UIQ6,Q8TEX9,P42892,Q9H7Z7,P55786 9 +Pre mrna binding 0.4921978687403162 1.444470482933135 0.148606676854764 1.0 0.3032316926475715 17 P22626,P14866,P62995,P09651,Q15637,Q9BWF3 6 +Aspartic type peptidase activity 0.7037483067103201 1.4259012582606967 0.1538968461811376 1.0 0.3125656875926981 6 Q8TCT8,Q8TCT9 2 +Electron transfer activity 0.384803189472415 1.4216285921744092 0.1551340998696511 1.0 0.3145908217170943 49 P13073,O95168,P14406,P21912,O75306,P16435,O96000,O43676,Q9UDW1 9 +Oxidoreduction driven active transmembrane transporter activity 0.4394957849058173 1.4082983754285567 0.1590427365211628 1.0 0.3200399152730005 28 P13073,O95168,O75306,O96000,O43676,Q9UDW1 6 +Peptide antigen binding 0.7279481428306993 1.3939883412495782 0.1633211253306932 1.0 0.3256776076814415 4 Q15392 1 +Thiolester hydrolase activity 0.5241590612842129 1.3939390144767203 0.1633360215623718 1.0 0.3256776076814415 14 P28288,P50897,Q9Y305,Q9NUJ1,Q9UMR5,O14734 6 +Gamma tubulin binding 0.7295283447752384 1.3918184076116895 0.1639773943471931 1.0 0.3264595540954758 5 Q13153,Q96CW5,Q9BSJ2 3 +Histone arginine n methyltransferase activity 0.6462526440572143 1.360381251196206 0.1737093083882663 1.0 0.3376249168970756 3 Q86X55 1 +Transition metal ion binding 0.3131101739836481 1.3482164125560978 0.1775887872838155 1.0 0.3426234334930756 161 P09960,P13674,Q32P28,P36551,Q16850,Q99640,P14373,P53004,Q969S3,O75845,P46976,Q15637,Q9BQ04,P55786,O43823,Q99536,Q99707,Q8N4Q0,Q9UIQ6,P42892,P05067,P00813,O95487,O60888,Q6UW02,Q5JTZ9,Q12899,Q9BWF3,Q15800,Q8NCC3,O75976,O75312,O95071,Q5JRX3,P49356,P43243,P62072,P31350,O00767,Q8WWV3 40 +Ubiquitin specific protease binding 0.6646654732068124 1.338029942763444 0.1808866761853718 1.0 0.3462353818881064 7 P46379 1 +Mrna 3 utr au rich region binding 0.5536322931108892 1.3228377729856176 0.1858893327109494 1.0 0.3527167288569351 12 Q13151,Q92945,Q01085,Q14103 4 +Sh3 domain binding 0.5126889237510052 1.3219421758460408 0.1861874066999775 1.0 0.3527167288569351 14 Q16204,O75525,Q07666,Q68EM7 4 +Bhlh transcription factor binding 0.5651537335285574 1.318961724121615 0.1871819089888893 1.0 0.3528176989574748 2 Q96EB6 1 +Atpase coupled transmembrane transporter activity 0.4717599226309194 1.3018967017250704 0.1929517001366814 1.0 0.3621299816318805 17 P28288,Q9HD20,O75027,P05023,P08183,P16615 6 +Phosphatidylserine binding 0.5964861159075489 1.2982343209063334 0.1942068278099191 1.0 0.3634442063299916 10 Q8WTV0 1 +Nucleobase containing compound kinase activity 0.4938330248318828 1.2784077619458056 0.2011056886399935 1.0 0.3736857476856618 15 O14936,Q14168,P55263 3 +Hsp70 protein binding 0.4887632563936693 1.2453246898433166 0.2130124236180406 1.0 0.3913420222767054 15 P46379,P23396 2 +Palmitoyl protein hydrolase activity 0.695023761830978 1.244552366689399 0.2132963388592119 1.0 0.3913420222767054 5 Q9NUJ1,P50897 2 +Antigen binding 0.6940815549539232 1.240525885884817 0.2147809457535117 1.0 0.3924711269098851 5 Q15392 1 +Poly g binding 0.6940628255242295 1.240445845503665 0.2148105328201432 1.0 0.3924711269098851 5 Q06787,Q96EP5,O14979 3 +Iron ion binding 0.4453081948063693 1.23129017234728 0.218214356208565 1.0 0.3966370410243884 21 Q15800,Q32P28,Q16850,Q6UW02,P31350,O00767 6 +Protein arginine n methyltransferase activity 0.6603470532057174 1.2306788208280393 0.2184430123596763 1.0 0.3966370410243884 6 Q6P2P2,Q7L592 2 +Translation activator activity 0.5475841874085001 1.2262430918112674 0.2201072096253702 1.0 0.3966370410243884 2 P11940 1 +Chloride channel inhibitor activity 0.6177310746526932 1.2260472898676706 0.2201808796717412 1.0 0.3966370410243884 3 Q9UEU0 1 +Hormone binding 0.6589128695045359 1.2242141497961343 0.2208714527068738 1.0 0.3966370410243884 6 P42892 1 +Protein carrier chaperone 0.6198564034893582 1.2169768956725422 0.2236130065922723 1.0 0.3996357962290269 8 Q15070 1 +Carbohydrate derivative transmembrane transporter activity 0.5784259498536519 1.2032382947264144 0.2288841197281053 1.0 0.4073888544073613 10 P12236,P41440,Q8TB61,P05141,L0R6Q1,Q99808 6 +Peptidyl proline dioxygenase activity 0.6769370686059283 1.1769689342373042 0.2392079059092302 1.0 0.4200567784733131 4 Q32P28 1 +Procollagen proline dioxygenase activity 0.6769370686059283 1.1769689342373042 0.2392079059092302 1.0 0.4200567784733131 4 Q32P28 1 +Structural constituent of postsynapse 0.6736428490845077 1.1629520030388605 0.2448489766076913 1.0 0.4266065072470465 4 Q16352 1 +Demethylase activity 0.5880122975531582 1.1532625646539143 0.2488026305803732 1.0 0.4305567319158374 9 Q16850 1 +Intramolecular oxidoreductase activity transposing c c bonds 0.6225904648162384 1.1413775225548823 0.2537128543300389 1.0 0.4372411220963746 7 Q15125 1 +O methyltransferase activity 0.6385973784653579 1.1326449359412132 0.2573633900380767 1.0 0.4418689920706167 6 O60725 1 +Mitogen activated protein kinase p38 binding 0.5252562225475846 1.1086034586694269 0.267601285424166 1.0 0.4529169042708754 2 Q16539 1 +Rna strand annealing activity 0.661662910805681 1.1020442714798866 0.2704424252328523 1.0 0.457134938135531 5 Q06787,P23588,O00571 3 +Long chain acyl coa dehydrogenase activity 0.5899260856050634 1.0952276017561813 0.2734169361557046 1.0 0.4589398819613014 3 Q9H845 1 +Phospholipid transporter activity 0.6591631642308141 1.0913821225334168 0.2751047755353459 1.0 0.4602646947015367 5 P08183 1 +Nucleoside monophosphate kinase activity 0.5741234698078052 1.0830499171228227 0.2787862671987335 1.0 0.464643778664556 9 O14936,Q14168 2 +Single stranded dna exodeoxyribonuclease activity 0.6543311624336057 1.0808856544648535 0.2797479806558354 1.0 0.4656541990586332 4 Q8IV08 1 +Purine nucleotide transmembrane transporter activity 0.5734394620512389 1.0795934914025274 0.2803232410381537 1.0 0.4660196012182505 9 P12236,P41440,Q8TB61,P05141,Q99808 5 +Ribosome binding 0.369838416857269 1.0700456903428044 0.2845987430834134 1.0 0.4695520824172185 37 Q96A33,Q15070,P46379,Q8WWC4,Q9NUL3,Q9UM00 6 +Nad dependent protein deacetylase activity 0.5172035139092229 1.066314900768561 0.2862813158834769 1.0 0.4717339922105092 2 Q96EB6 1 +Cyclin dependent protein serine threonine kinase regulator activity 0.6495248257888666 1.0605016590977103 0.2889164355856377 1.0 0.4742863792195306 4 P11802 1 +Amino acid transmembrane transporter activity 0.5672648875214596 1.0484037456297874 0.294452628560333 1.0 0.480963769842938 9 Q9Y619,P08195,P30825,Q9H9B4 4 +Flavin adenine dinucleotide binding 0.4091258253456509 1.0468005076635654 0.2951915962084375 1.0 0.4811912601689485 24 Q15392,Q15067,O15254,A1L0T0,P16435,Q14534 6 +Symporter activity 0.6486306895325447 1.0465080192858864 0.295326544409034 1.0 0.4811912601689485 5 P53985,O00400 2 +Amide binding 0.3116753929072533 1.0197091552387594 0.3078664183778181 1.0 0.4931976223489567 93 Q8WTV0,O00264,P01889,Q15392,P24390,P21796,Q9NZJ7,Q9UIQ6,P62942,P45880,P41440,P42892,Q8TEX9,P07602,Q9H7Z7,P55786 16 +Nadh dehydrogenase activity 0.4174040728660961 1.0195787421606393 0.3079282910558309 1.0 0.4931976223489567 21 O96000,O75306,O43676,O95168 4 +Cobalamin binding 0.571658978380205 1.0096815379244737 0.3126478904598786 1.0 0.4983450276986306 3 Q96EY8 1 +Thiol oxidase activity 0.4981698389458339 0.9668784451658348 0.3336048031859124 1.0 0.5258992685602231 2 Q96HE7 1 +Phospholipid binding 0.3145293283628275 0.9601146062231736 0.3369975380916876 1.0 0.5306091044472485 78 Q8WTV0,Q8NCC3,Q14108,P50897,P21796,Q9H6U6,Q9NZJ7,P22059,P45880,Q9H4A6,P07602,O60313 12 +Long chain fatty acyl coa binding 0.4963396778916653 0.9573668208836716 0.3383821390759882 1.0 0.5311422499120133 2 O00154 1 +Pre mrna intronic binding 0.6276163307325311 0.9573212420426206 0.3384051368734049 1.0 0.5311422499120133 5 Q9BWF3,P22626 2 +Metal dependent deubiquitinase activity 0.5828890815548414 0.9562262216826302 0.3389579549056818 1.0 0.5311422499120133 7 Q7L5N1 1 +N6 methyladenosine containing rna binding 0.5987724704722464 0.9538102078301632 0.3401797213838207 1.0 0.5311470619634157 6 P07910,Q96MU7,Q9H6S0,P22626 4 +Dioxygenase activity 0.4222101246919569 0.9528144203996072 0.3406841065884953 1.0 0.5311470619634157 17 Q32P28,O00625,P16435 3 +Calcium ion transmembrane transporter activity 0.5130121062978125 0.9526444904306318 0.3407702271630997 1.0 0.5311470619634157 11 Q9HC07,O95202,P16615,Q9UM00 4 +1 4 alpha oligoglucan phosphorylase activity 0.5589671353853816 0.950578191591694 0.3418185436847434 1.0 0.5311470619634157 3 Q13126 1 +Hydrolase activity acting on glycosyl bonds 0.397141791119888 0.9503425378767426 0.3419382312365964 1.0 0.5311470619634157 24 P23396,O60502,Q9BTY2,P08236,P54802,P13051,P06865,Q9NUJ1,P04062,O75503 10 +Solute anion antiporter activity 0.6209939730297437 0.9293462220100848 0.3527096882007257 1.0 0.5442281408044177 5 P41440,Q02978 2 +Coa hydrolase activity 0.5592707419617438 0.9232455821767728 0.3558792395080945 1.0 0.5463579103945384 8 Q9Y305,P28288,P50897,O14734 4 +Mhc class i protein binding 0.5756520675351693 0.9226774714663264 0.3561753095243785 1.0 0.5463579103945384 7 Q9BUN8 1 +Mhc protein binding 0.5564357519146654 0.909598432456712 0.363034325595629 1.0 0.5554530187906657 8 Q9BUN8 1 +Metal ion transmembrane transporter activity 0.4374364891870619 0.9091483435963802 0.3632718270381296 1.0 0.5554530187906657 15 Q9HC07,Q9HD20,P16615,Q9UM00 4 +3 hydroxyacyl coa dehydrogenase activity 0.5839790974558949 0.8879261399914427 0.3745804826781098 1.0 0.5685984151892514 6 Q53GQ0,Q16836 2 +Proteasome binding 0.498673648721728 0.8742610002977739 0.3819761328249864 1.0 0.57551420846159 11 P46379 1 +Histone h3 methyl lysine 36 demethylase activity 0.5400549487361809 0.8632427675725189 0.3880040040025443 1.0 0.580234298222983 3 Q8IUF8 1 +Co smad binding 0.475475841874093 0.8497763468252015 0.3954494424690142 1.0 0.5886804200391008 2 Q93008 1 +Protein kinase b binding 0.4743777452415915 0.8441639089021471 0.3985778192514575 1.0 0.5926639537110208 2 Q9UKG1 1 +Intermediate filament binding 0.5964043370280658 0.8374615531006293 0.4023331792459665 1.0 0.5968929386321814 4 P08670 1 +Beta tubulin binding 0.4044142703799005 0.8275151345943709 0.4079451474580036 1.0 0.6004585878314435 17 Q9H6U6,O75381 2 +Phosphate ion binding 0.5937085767528847 0.8263053888076064 0.4086308773869 1.0 0.6007928724768116 4 Q8NCH0 1 +Lys48 specific deubiquitinase activity 0.5298425485170268 0.8165567724289791 0.4141817670488978 1.0 0.6074153418319976 3 Q9Y4E8,Q93009 2 +Oxidoreductase activity acting on a heme group of donors 0.5665913891878698 0.8111282943674566 0.4172919987006309 1.0 0.6101032570288243 6 P16435,P13073 2 +Isopeptidase activity 0.5193055946105707 0.8079107880223984 0.4191419405159617 1.0 0.6121247960712485 9 Q7L5N1 1 +Protein methyltransferase activity 0.3861431626009021 0.7824854647232575 0.4339293243228188 1.0 0.6241245403572131 21 O60725,Q6P2P2,Q52LJ0,Q7L592,Q86X55 5 +Misfolded protein binding 0.4923787856847548 0.7527698230433382 0.4515882436133009 1.0 0.6451260623047157 10 P46379 1 +Transferase activity transferring one carbon groups 0.3245685997828069 0.7376441438356983 0.4607307227914763 1.0 0.65604048571395 46 Q8N6R0,Q9H993,P21964,O60725,Q99707,Q8IYR2,P04818,Q6P2P2,Q52LJ0,Q7L592,Q86X55 11 +Protein kinase a regulatory subunit binding 0.5494348221979845 0.7362600186450895 0.4615724727540593 1.0 0.6561808182349812 6 Q9ULX6 1 +Tau protein kinase activity 0.5108019040644453 0.730667526018712 0.4649822555344043 1.0 0.6592280895563525 3 P49841,P49840 2 +L aspartate transmembrane transporter activity 0.56913218828108 0.7256924865622125 0.4680273088299616 1.0 0.6613978150671518 4 Q9UJS0,Q9H936 2 +Acidic amino acid transmembrane transporter activity 0.56913218828108 0.7256924865622125 0.4680273088299616 1.0 0.6613978150671518 4 Q9UJS0,Q9H936 2 +Oxidoreductase activity acting on nad p h 0.3578129839231897 0.7124796934333821 0.4761677816867742 1.0 0.6692916244738993 28 O95168,Q13423,O75306,P16435,O96000,Q9Y6M9,Q7KZN9,O43676 8 +Ubiquitin conjugating enzyme binding 0.5125621186217633 0.7012358237773983 0.4831558567004972 1.0 0.6783860367391762 8 Q9BTE7,Q92564 2 +Transmembrane transporter binding 0.3550756424076887 0.6893313887472096 0.4906147494094945 1.0 0.6830574742584955 28 P21796,P62942 2 +Atpase coupled cation transmembrane transporter activity 0.4429685470053626 0.6867634831718645 0.4922317848228896 1.0 0.6830574742584955 12 Q9HD20 1 +Modified amino acid binding 0.3734397365074955 0.6641092740176677 0.5066203749126361 1.0 0.69393897885997 20 Q8WTV0,Q14108,Q9H7Z7 3 +G quadruplex rna binding 0.4359443631039508 0.6522492554599599 0.5142403897089287 1.0 0.6989761902868437 2 Q06787 1 +Palmitoyltransferase activity 0.5537762025822273 0.6519277231894655 0.5144477995738452 1.0 0.6989761902868437 5 P23786 1 +Transferase activity transferring alkyl or aryl other than methyl groups 0.3788623442630245 0.6495826955889213 0.51596181374609 1.0 0.6989761902868437 17 P49366,P78417,P37268,P19623,P14324,P49356,Q96EY8 7 +Death domain binding 0.4922166539160612 0.6486628335516299 0.516556332430576 1.0 0.6990586730207174 3 Q13546 1 +Atpase binding 0.3524325036050881 0.645403295480603 0.518665868362969 1.0 0.7010261494631117 27 Q93050,Q9BUN8,Q9Y487 3 +Fk506 binding 0.5273035661877166 0.6414650574880142 0.5212205763139162 1.0 0.7017460996621071 6 P62942 1 +Macrolide binding 0.5273035661877166 0.6414650574880142 0.5212205763139162 1.0 0.7017460996621071 6 P62942 1 +Palmitoyl coa hydrolase activity 0.5247576965789751 0.6307158470218895 0.5282263355308168 1.0 0.7082666320832856 6 P50897,O14734 2 +G protein alpha subunit binding 0.543662811955785 0.6240646714723215 0.5325851141040367 1.0 0.7097522883787265 4 Q02818 1 +Protein deacetylase activity 0.4855364335408277 0.6197230668252306 0.5354401265075879 1.0 0.7128318757367277 3 Q92769,Q96EB6 2 +Fatty acid binding 0.5078557259748164 0.615886851860208 0.5379691998772873 1.0 0.7136327247850534 7 O15254 1 +Acetyl coa hydrolase activity 0.4846318188357083 0.6158283480016655 0.5380078156597743 1.0 0.7136327247850534 3 O14734 1 +Scaffold protein binding 0.371429781497189 0.5985909803349212 0.5494456722756027 1.0 0.7240199038954923 17 Q8IWS0,Q9UQB8,Q9NZJ7,P07602,P08670 5 +Mrna binding 0.2710081436041868 0.5923226718029446 0.5536345368872153 1.0 0.7259872305528049 163 P52272,O60506,O75153,P67809,O43390,P61978,Q15637,Q92945,Q9BQ04,Q9NPI6,Q71RC2,Q99729,P35637,P23396,P14866,Q14103,Q13151,Q15631,P62995,Q96PK6,O95453,Q96AE4,Q96EP5,P22626,P04818,P17844,P51991,P38159,Q92804,Q9BWF3,O75525,Q93062,Q07955,Q07666,Q01085,Q14671,Q96I24,Q15287,P14618,Q8IY67,P31483 41 +Phosphotransferase activity phosphate group as acceptor 0.4413431303228441 0.5682311365064528 0.569878031719478 1.0 0.74119752427461 11 O14936,Q14168 2 +Transferase activity transferring sulphur containing groups 0.5274211579229624 0.5610804475756263 0.5747426965557372 1.0 0.7461971580654269 4 Q8NCH0 1 +Hydrolase activity hydrolyzing o glycosyl compounds 0.3627708185954528 0.5528489362929512 0.5803668559429918 1.0 0.7512653965269952 18 Q9BTY2,O60502,P08236,P54802,P06865,Q9NUJ1,P04062 7 +Peptidase activator activity involved in apoptotic process 0.4662921077460277 0.5382471832446369 0.5904064096134034 1.0 0.7612523588519275 3 P53634 1 +Serine type exopeptidase activity 0.4889293434238597 0.534232412267865 0.593180746925976 1.0 0.761547867938336 7 P42785,O14773 2 +S adenosylmethionine dependent methyltransferase activity 0.3294426505535405 0.5185864099541065 0.6040491880612713 1.0 0.771251887290707 30 P21964,O60725,Q6P2P2 3 +Phosphatidylinositol 4 phosphate binding 0.4837227808757738 0.5122171132089729 0.6084990673982884 1.0 0.7754219633188305 7 P22059 1 +Coreceptor activity 0.4030014641288412 0.4978073839647388 0.6186198109735799 1.0 0.7807244242537489 2 Q13308 1 +Chemokine binding 0.4030014641288407 0.4978073839647369 0.6186198109735812 1.0 0.7807244242537489 2 P09429 1 +Folic acid binding 0.4539556167275381 0.4877218458836568 0.6257468757684381 1.0 0.7851804667209329 3 P41440 1 +Dna n glycosylase activity 0.506847782971264 0.4838367925076236 0.6285017013094789 1.0 0.7878825155171457 4 P23396 1 +N acyltransferase activity 0.353754837418026 0.4794589242163748 0.6316121830625754 1.0 0.7887625927664192 17 Q96G23 1 +Kinase activity 0.2674498259191656 0.4432044457063852 0.6576178635537846 1.0 0.8081420274441443 111 Q13057,Q8NEB9,Q99640,Q8TBX8,P11802,Q13546,P35790,P49840,P48729,P55263,P36507,O14936,Q13153,Q9BRR6,Q00013,Q15120,P31751,Q13555,Q14168,Q8WVC6,P52789,P14618 22 +Protein self association 0.3977926641646579 0.4406977390191865 0.6594318336516347 1.0 0.8088874441158443 12 Q9Y282,P11166,P53634 3 +Pdz domain binding 0.4080232565998074 0.4010497701544497 0.688383481230507 1.0 0.8299394718755613 11 Q9UQB8,Q15067,P51790 3 +Procollagen proline 4 dioxygenase activity 0.4317099963383377 0.4006498592978049 0.6886779314687972 1.0 0.8299394718755613 3 P13674,P07237 2 +Peptidyl proline 4 dioxygenase activity 0.4317099963383377 0.4006498592978049 0.6886779314687972 1.0 0.8299394718755613 3 P13674,P07237 2 +Long chain fatty acid coa ligase activity 0.4831011642729539 0.3989544296971501 0.6899267823454094 1.0 0.8299394718755613 4 O60488 1 +Fatty acid ligase activity 0.4831011642729539 0.3989544296971501 0.6899267823454094 1.0 0.8299394718755613 4 O60488 1 +Arachidonate coa ligase activity 0.4831011642729539 0.3989544296971501 0.6899267823454094 1.0 0.8299394718755613 4 O60488 1 +Steroid dehydrogenase activity 0.455759328961401 0.3979964915166266 0.6906327719514072 1.0 0.8300265424370122 7 Q3SXM5 1 +Oxidoreductase activity acting on nad p h quinone or similar compound as acceptor 0.3289164828313426 0.3960127336902789 0.6920956344271749 1.0 0.8310222558199809 23 O96000,O75306,O43676,O95168 4 +Mitogen activated protein kinase binding 0.4649561665405036 0.3912531690134493 0.6956101110259536 1.0 0.8329517782851913 6 Q9NUL3,Q96EB6,Q96JB5 3 +Vitamin d receptor binding 0.4805860805860823 0.3902709069170477 0.6963362339384762 1.0 0.8330597867209167 4 Q9Y2W1,O75448,Q15648 3 +Chaperone binding 0.2956305136301353 0.383410229596525 0.7014156196870647 1.0 0.8383708592974951 41 P53634,Q14108,O95429,P62072,P01889,O43615 6 +Serine type carboxypeptidase activity 0.4795144784333919 0.372796891208155 0.7092996167936896 1.0 0.845479979981559 5 P42785 1 +E box binding 0.3674963396778841 0.3472920569650836 0.7283719175025571 1.0 0.8658504645447821 2 O14744 1 +Cytoskeletal anchor activity 0.4713552233889159 0.3449763470147034 0.7301121527823329 1.0 0.8663468479572972 5 Q9UQB8 1 +Growth factor binding 0.406454227403481 0.3365025286455526 0.7364919450612186 1.0 0.8711554805644427 10 O43847,Q92896 2 +Calcium ion binding 0.2723069012383351 0.336061307383547 0.736824635469773 1.0 0.8711554805644427 72 Q96A33,O95202,O43852,P80303,Q14257,Q9NWM8,Q9BRK5,Q02818,Q9Y680,O43681,P16615 11 +Mitochondrion targeting sequence binding 0.3601756954611948 0.3188811109902654 0.7498166684187841 1.0 0.8844451740254876 2 Q15388 1 +Molecular carrier activity 0.3092037490058772 0.3146107915692566 0.7530571844798972 1.0 0.8856185736589408 28 Q15070,O75880,Q15006,Q5J8M3,Q92973,Q9Y5L0,O43819,Q8TEX9,P40855,P62072,O00410,Q96P70 12 +Chloride channel regulator activity 0.457767620832902 0.3145362222781619 0.753113809966458 1.0 0.8856185736589408 4 Q9UEU0 1 +Hexosyltransferase activity 0.3103236437361922 0.3088492296654354 0.7574362186924697 1.0 0.8880362020283414 27 Q13126,Q9BT22,Q96L58,P46977,P06737,P04062 6 +Nad binding 0.308384308367137 0.3082642354218822 0.7578812777615922 1.0 0.8880362020283414 28 O75306,P00367,Q13363,P40939,Q16836 5 +Microtubule minus end binding 0.4587778609883825 0.3035106324658211 0.761500745858124 1.0 0.8890962362514638 5 Q9BSJ2,Q9H6D7 2 +G rich strand telomeric dna binding 0.4540229229052919 0.288310229574487 0.7731092773951305 1.0 0.8994432978575675 5 P22626 1 +Histone h3 methyl lysine 9 demethylase activity 0.3958257048700112 0.273666186343836 0.7843411654250392 1.0 0.9044779284390856 3 Q9UPP1,O60341 2 +Ubiquitin like protein conjugating enzyme binding 0.3636617825432228 0.2703100756651351 0.7869217145320699 1.0 0.9054364564535224 12 Q9BTE7,Q92564,P23396 3 +Transcription coactivator binding 0.4413919413919429 0.2639130828132509 0.7918468943199721 1.0 0.9078525501292756 4 P42224,Q15648,Q00059 3 +Galactoside binding 0.3448023426061428 0.2626236674558896 0.7928406562266761 1.0 0.9078525501292756 2 P16278 1 +Galactosidase activity 0.3448023426061428 0.2626236674558896 0.7928406562266761 1.0 0.9078525501292756 2 P16278 1 +Phosphoric diester hydrolase activity 0.3761563967853465 0.2541133371255165 0.7994079999585733 1.0 0.9098388183716168 11 P09601,Q8IV08 2 +C acyltransferase activity 0.3848914712440124 0.2449604989962178 0.8064870168904335 1.0 0.91670831544435 10 P40939,Q9BWD1 2 +Histone acetyltransferase binding 0.4394646864280071 0.2435100155284453 0.8076103273143911 1.0 0.9167846869860072 5 Q9H6U6 1 +2 iron 2 sulfur cluster binding 0.390983494255038 0.2287513635996588 0.8190621706685406 1.0 0.9254488836860728 9 Q9NZ45 1 +1 acylglycerophosphocholine o acyltransferase activity 0.3268667642752483 0.2033499916969181 0.838861483958828 1.0 0.9371439922909708 2 Q8NF37 1 +Estradiol 17 beta dehydrogenase activity 0.4192886065882001 0.2011668842512489 0.8405680846884662 1.0 0.9371439922909708 4 Q53GQ0,P51659 2 +17 beta hydroxysteroid dehydrogenase nadplus activity 0.4192886065882001 0.2011668842512489 0.8405680846884662 1.0 0.9371439922909708 4 Q53GQ0,P51659 2 +Peptide lysine n acetyltransferase activity 0.3999152553326721 0.1970175341654415 0.8438138164227948 1.0 0.939418801816256 7 Q86UY6,O14929,Q9GZZ1,O95251 4 +Cis trans isomerase activity 0.3015454542996174 0.1947601384511089 0.8455807295623623 1.0 0.9403317111432042 22 P62942,Q9Y680,Q9NWM8 3 +Nadp binding 0.3072409065201332 0.1896190541599663 0.8496076550362615 1.0 0.9429515671112774 17 P16435,Q9UBM7,Q14739 3 +Snare binding 0.2950199836311563 0.1775984015339752 0.8590383799783334 1.0 0.950028605543012 25 O15400,O95487,P51809,Q13190,Q9UEU0 5 +Cytokine receptor binding 0.2974003186379476 0.1681858771759269 0.8664370510654336 1.0 0.951504381499715 22 P62993,P62942,Q96J02,Q13546 4 +Metallocarboxypeptidase activity 0.4032426585865215 0.1600021092642565 0.872879412672501 1.0 0.9551273246784464 4 P36551 1 +Peptide alpha n acetyltransferase activity 0.4083954371722411 0.1575263366796397 0.8748300533318287 1.0 0.9558193243241832 5 Q86UY6,P41227 2 +C acetyltransferase activity 0.3918021973631647 0.1511044731808759 0.8798933039313659 1.0 0.9589519368969128 6 Q9BWD1 1 +Dynein light intermediate chain binding 0.4004714163945334 0.137872078512788 0.8903415177536784 1.0 0.9637025612571452 5 Q96FJ2,Q8TD16 2 +Acetyl coa c acetyltransferase activity 0.4001931347008736 0.1371994684474855 0.8908731310552693 1.0 0.9637025612571452 5 P40939,Q9BWD1 2 +Structural constituent of synapse 0.3850087811026617 0.1328587398475445 0.8943050983816632 1.0 0.966616896765659 6 Q16352 1 +Ubiquitin like protein specific protease activity 0.287833061627575 0.1237968762494806 0.9014761051807948 1.0 0.9711625804168104 24 Q93009,Q96FW1,O00487,Q92905,Q7L5N1,Q96K76,Q9H4L4,Q9BT78,O95630,P51784 10 +Kinesin binding 0.3513837192362838 0.1190369108948575 0.9052461130017208 1.0 0.9720265639608642 10 Q96EK5,Q9NUL3,Q9H0B6 3 +Adp transmembrane transporter activity 0.3830857160954475 0.1138935130264236 0.9093222079607216 1.0 0.9743757034651216 4 P12236 1 +Glucose binding 0.3899003234054847 0.1131760639154402 0.9098909719529868 1.0 0.9743757034651216 5 P06737 1 +Peptide n acetyltransferase activity 0.3489334060794078 0.1107272018611837 0.9118326746471972 1.0 0.9749699025355558 10 O95251,Q86UY6,P41227,O14929,Q9GZZ1 5 +Protein serine kinase activity 0.2593413348959589 0.0807220012601429 0.9356630394364815 1.0 0.9900858936326388 48 Q99640,P48729,P11802,P31751,P36507,O14936,Q13153,Q13555,Q13546 9 +Single stranded telomeric dna binding 0.3586329996218316 0.0696296841855955 0.94448840970975 1.0 0.9986116357705994 6 P22626 1 +Protein demethylase activity 0.3562920905801065 0.0646187353742606 0.9484775672137752 1.0 1.0 6 Q8IUF8 1 +Atp transmembrane transporter activity 0.3626269099451542 0.0577555274976853 0.9539433629255732 1.0 1.0 5 P12236 1 +Sequence specific single stranded dna binding 0.3455317944881863 0.0493563690383982 0.9606352982200616 1.0 1.0 7 P22626 1 +Glucosyltransferase activity 0.3444653506530232 0.0470168905626774 0.962499765693136 1.0 1.0 7 P04062 1 +Acetyl coa c acyltransferase activity 0.3444044753584293 0.04688401740608 0.9626056663481092 1.0 1.0 7 Q9BWD1 1 +Heparin binding 0.3268707583610672 0.0420509925440259 0.9664580478677998 1.0 1.0 10 P05067 1 +Gtpase activating protein binding 0.351085470905192 0.0379513534119358 0.9697264684130515 1.0 1.0 5 Q14C86 1 +Ubiquitination like modification dependent protein binding 0.347013558079877 0.0314792423497975 0.9748873461453044 1.0 1.0 5 P14735,Q9Y4E8,Q16658,Q99543 4 +Histone deacetylase binding 0.2677398676754194 0.0144672591004699 0.9884571999823965 1.0 1.0 27 Q8IWS0,Q9ULX6,O43823,Q14103 4 +Nadp retinol dehydrogenase activity 0.3179487179487202 0.0092335348633239 0.9926328097765889 1.0 1.0 4 Q8TC12,Q9HBH5,Q8NBN7 3 diff --git a/msigdb_gomf/selections.json b/msigdb_gomf/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..8d8705f72b80e38b8c81ed13b706db306a5bcda3 --- /dev/null +++ b/msigdb_gomf/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["1 4 alpha oligoglucan phosphorylase activity", "1 acylglycerophosphocholine o acyltransferase activity", "1 alkyl 2 acetylglycerophosphocholine esterase activity", "1 phosphatidylinositol 3 kinase activity", "1 phosphatidylinositol 4 kinase activity", "1 phosphatidylinositol 4 phosphate 5 kinase activity", "1 phosphatidylinositol binding", "14 3 3 protein binding", "17 beta hydroxysteroid dehydrogenase nadplus activity", "17 beta hydroxysteroid dehydrogenase nadpplus activity", "2 acylglycerol 3 phosphate o acyltransferase activity", "2 iron 2 sulfur cluster binding", "2 oxoglutarate dependent dioxygenase activity", "3 5 dna helicase activity", "3 5 exodeoxyribonuclease activity", "3 5 exonuclease activity", "3 beta hydroxy delta5 steroid dehydrogenase activity", "3 hydroxyacyl coa dehydratase activity", "3 hydroxyacyl coa dehydrogenase activity", "4 iron 4 sulfur cluster binding", "5 3 dna helicase activity", "5 3 exodeoxyribonuclease activity", "5 3 exonuclease activity", "5 deoxyribose 5 phosphate lyase activity", "5s rrna binding", "7s rna binding", "7sk snrna binding", "Abc type transporter activity", "Abc type xenobiotic transporter activity", "Acetyl coa c acetyltransferase activity", "Acetyl coa c acyltransferase activity", "Acetyl coa hydrolase activity", "Acetylcholine receptor binding", "Acetylgalactosaminyltransferase activity", "Acetylglucosaminyltransferase activity", "Acetyltransferase activity", "Acid amino acid ligase activity", "Acid phosphatase activity", "Acid thiol ligase activity", "Acidic amino acid transmembrane transporter activity", "Actin binding", "Actin filament binding", "Actin monomer binding", "Actinin binding", "Active ion transmembrane transporter activity", "Active transmembrane transporter activity", "Activin binding", "Acyl carnitine transmembrane transporter activity", "Acyl coa binding", "Acyl coa dehydrogenase activity", "Acyl coa oxidase activity", "Acylglycerol lipase activity", "Acylglycerol o acyltransferase activity", "Acyltransferase activity", "Acyltransferase acyl groups converted into alkyl on transfer", "Adenosine deaminase activity", "Adenyl nucleotide binding", "Adenyl nucleotide exchange factor activity", "Adenylate cyclase binding", "Adenylate kinase activity", "Adenylyltransferase activity", "Adp binding", "Adp ribose diphosphatase activity", "Adp transmembrane transporter activity", "Adrenergic receptor binding", "Alanine transmembrane transporter activity", "Alcohol binding", "Alcohol dehydrogenase activity zinc dependent", "Alcohol dehydrogenase nad p plus activity", "Alcohol dehydrogenase nadpplus activity", "Aldehyde dehydrogenase nad p plus activity", "Aldehyde lyase activity", "Alditol nadpplus 1 oxidoreductase activity", "Aldo keto reductase nadp activity", "Alkali metal ion binding", "Alpha actinin binding", "Alpha catenin binding", "Alpha glucosidase activity", "Alpha tubulin binding", "Amide binding", "Amide transmembrane transporter activity", "Amidine lyase activity", "Amino acid binding", "Amino acid cation symporter activity", "Amino acid proton symporter activity", "Amino acid transmembrane transporter activity", "Aminoacyl trna editing activity", "Aminoacylase activity", "Aminoacyltransferase activity", "Aminopeptidase activity", "Amp activated protein kinase activity", "Amp binding", "Amyloid beta binding", "Anaphase promoting complex binding", "Androgen receptor binding", "Androstan 3 alpha 17 beta diol dehydrogenase activity", "Anion channel activity", "Anion transmembrane transporter activity", "Ankyrin binding", "Ankyrin repeat binding", "Annealing activity", "Antigen binding", "Antioxidant activity", "Antiporter activity", "Apolipoprotein a i binding", "Apolipoprotein binding", "Apolipoprotein receptor binding", "Arachidonate coa ligase activity", "Arginine binding", "Armadillo repeat domain binding", "Aromatic amino acid transmembrane transporter activity", "Arp2 3 complex binding", "Arrestin family protein binding", "Aryl hydrocarbon receptor binding", "Arylesterase activity", "Arylsulfatase activity", "Aspartic endopeptidase activity intramembrane cleaving", "Aspartic type endopeptidase inhibitor activity", "Aspartic type peptidase activity", "Atp dependent activity", "Atp dependent activity acting on dna", "Atp dependent activity acting on rna", "Atp dependent chromatin remodeler activity", "Atp dependent dna dna annealing activity", "Atp dependent peptidase activity", "Atp dependent protein binding", "Atp hydrolysis activity", "Atp transmembrane transporter activity", "Atpase activator activity", "Atpase binding", "Atpase coupled cation transmembrane transporter activity", "Atpase coupled intramembrane lipid transporter activity", "Atpase coupled ion transmembrane transporter activity", "Atpase coupled transmembrane transporter activity", "Atpase inhibitor activity", "Atpase regulator activity", "Azole transmembrane transporter activity", "Basal transcription machinery binding", "Basic amino acid transmembrane transporter activity", "Beta 1 3 galactosyltransferase activity", "Beta 2 adrenergic receptor binding", "Beta 2 microglobulin binding", "Beta catenin binding", "Beta galactosidase activity", "Beta n acetylhexosaminidase activity", "Beta tubulin binding", "Bh domain binding", "Bh3 domain binding", "Bhlh transcription factor binding", "Bile acid binding", "Biotin binding", "Box h aca snorna binding", "Branched chain amino acid transmembrane transporter activity", "Bubble dna binding", "C acetyltransferase activity", "C acyltransferase activity", "C methyltransferase activity", "C palmitoyltransferase activity", "C x c chemokine binding", "C x3 c chemokine binding", "C2h2 zinc finger domain binding", "C3hc4 type ring finger domain binding", "C4 dicarboxylate transmembrane transporter activity", "Cadherin binding", "Cadherin binding involved in cell cell adhesion", "Calcium cation antiporter activity", "Calcium channel inhibitor activity", "Calcium channel regulator activity", "Calcium dependent cysteine type endopeptidase activity", "Calcium dependent phospholipid binding", "Calcium dependent protein binding", "Calcium dependent protein kinase activity", "Calcium dependent protein serine threonine phosphatase activity", "Calcium independent phospholipase a2 activity", "Calcium ion binding", "Calcium ion transmembrane transporter activity", "Calmodulin binding", "Calmodulin dependent protein kinase activity", "Camp binding", "Camp dependent protein kinase activity", "Camp dependent protein kinase inhibitor activity", "Camp dependent protein kinase regulator activity", "Carbohydrate binding", "Carbohydrate derivative transmembrane transporter activity", "Carbohydrate kinase activity", "Carbohydrate phosphatase activity", "Carbohydrate transmembrane transporter activity", "Carbon carbon lyase activity", "Carbon nitrogen ligase activity with glutamine as amido n donor", "Carbon nitrogen lyase activity", "Carbon oxygen lyase activity", "Carbon sulfur lyase activity", "Carbonyl reductase nadph activity", "Carboxy lyase activity", "Carboxylic acid binding", "Carboxylic ester hydrolase activity", "Carboxypeptidase activity", "Card domain binding", "Cardiolipin binding", "Cargo adaptor activity", "Cargo receptor activity", "Carnitine o acyltransferase activity", "Catalytic activity acting on a glycoprotein", "Catalytic activity acting on a nucleic acid", "Catalytic activity acting on a rrna", "Catalytic activity acting on a trna", "Catalytic activity acting on dna", "Catalytic activity acting on rna", "Cation cation antiporter activity", "Cation channel activity", "Cation transmembrane transporter activity", "Ccr chemokine receptor binding", "Ccr3 chemokine receptor binding", "Ccr5 chemokine receptor binding", "Cdp alcohol phosphatidyltransferase activity", "Cell adhesion mediator activity", "Cell adhesion molecule binding", "Cell adhesive protein binding involved in bundle of his cell purkinje myocyte communication", "Cell cell adhesion mediator activity", "Cell matrix adhesion mediator activity", "Centromeric dna binding", "Ceramide binding", "Cgmp binding", "Channel inhibitor activity", "Channel regulator activity", "Chaperone binding", "Chemoattractant activity", "Chemokine binding", "Chemokine receptor binding", "Chitin binding", "Chloride channel inhibitor activity", "Chloride channel regulator activity", "Chloride ion binding", "Cholesterol binding", "Chondroitin sulfate binding", "Chromatin binding", "Chromatin dna binding", "Chromo shadow domain binding", "Cis regulatory region sequence specific dna binding", "Cis trans isomerase activity", "Class i dna apurinic or apyrimidinic site endonuclease activity", "Clathrin binding", "Clathrin heavy chain binding", "Clathrin light chain binding", "Co smad binding", "Coa hydrolase activity", "Cobalamin binding", "Collagen binding", "Collagen binding involved in cell matrix adhesion", "Complement binding", "Complement component c1q complex binding", "Complement component c3b binding", "Copper chaperone activity", "Copper ion binding", "Core promoter sequence specific dna binding", "Coreceptor activity", "Coreceptor activity involved in wnt signaling pathway", "Coreceptor activity involved in wnt signaling pathway planar cell polarity pathway", "Cullin family protein binding", "Cuprous ion binding", "Cxcr chemokine receptor binding", "Cyclase activity", "Cyclase regulator activity", "Cyclic nucleotide binding", "Cyclic nucleotide dependent protein kinase activity", "Cyclic nucleotide phosphodiesterase activity", "Cyclin binding", "Cyclin dependent protein kinase activity", "Cyclin dependent protein serine threonine kinase activator activity", "Cyclin dependent protein serine threonine kinase inhibitor activity", "Cyclin dependent protein serine threonine kinase regulator activity", "Cyclohydrolase activity", "Cyclosporin a binding", "Cysteine type endopeptidase activity", "Cysteine type endopeptidase activity involved in apoptotic process", "Cysteine type endopeptidase activity involved in apoptotic signaling pathway", "Cysteine type endopeptidase inhibitor activity", "Cysteine type endopeptidase inhibitor activity involved in apoptotic process", "Cysteine type endopeptidase regulator activity involved in apoptotic process", "Cysteine type exopeptidase activity", "Cysteine type peptidase activity", "Cytidylyltransferase activity", "Cytochrome b5 reductase activity acting on nad p h", "Cytokine activity", "Cytokine binding", "Cytokine receptor binding", "Cytoskeletal anchor activity", "Cytoskeletal motor activity", "Cytoskeletal protein binding", "Cytoskeleton nuclear membrane anchor activity", "D glucose transmembrane transporter activity", "D threo aldose 1 dehydrogenase activity", "D1 dopamine receptor binding", "Damaged dna binding", "Deacetylase activity", "Dead h box rna helicase binding", "Deaminase activity", "Death domain binding", "Death receptor activity", "Death receptor binding", "Dehydroascorbic acid transmembrane transporter activity", "Demethylase activity", "Deoxynucleoside kinase activity", "Deoxyribonuclease activity", "Deoxyribonuclease i activity", "Diacylglycerol binding", "Diacylglycerol kinase activity", "Dicarboxylic acid transmembrane transporter activity", "Dihydropyrimidinase activity", "Dioxygenase activity", "Dipeptidase activity", "Dipeptidyl peptidase activity", "Diphosphotransferase activity", "Disordered domain specific binding", "Disulfide oxidoreductase activity", "Dna apurinic or apyrimidinic site endonuclease activity", "Dna binding bending", "Dna binding transcription activator activity", "Dna binding transcription factor activity", "Dna binding transcription factor binding", "Dna binding transcription repressor activity", "Dna clamp loader activity", "Dna directed dna polymerase activity", "Dna dna annealing activity", "Dna helicase activity", "Dna insertion or deletion binding", "Dna methyltransferase activity", "Dna n glycosylase activity", "Dna polymerase activity", "Dna polymerase binding", "Dna replication origin binding", "Dna secondary structure binding", "Dna topoisomerase activity", "Dolichyl diphosphooligosaccharide protein glycotransferase activity", "Dolichyl phosphate mannose protein mannosyltransferase activity", "Dopamine receptor binding", "Double stranded methylated dna binding", "Double stranded rna adenosine deaminase activity", "Double stranded rna binding", "Double stranded telomeric dna binding", "Dttp diphosphatase activity", "Dynactin binding", "Dynein complex binding", "Dynein heavy chain binding", "Dynein intermediate chain binding", "Dynein light chain binding", "Dynein light intermediate chain binding", "Dystroglycan binding", "E box binding", "Efflux transmembrane transporter activity", "Electron transfer activity", "Endodeoxyribonuclease activity", "Endodeoxyribonuclease activity producing 5 phosphomonoesters", "Endonuclease activity", "Endonuclease activity active with either ribo or deoxyribonucleic acids and producing 3 phosphomonoesters", "Endonuclease activity active with either ribo or deoxyribonucleic acids and producing 5 phosphomonoesters", "Endopeptidase activator activity", "Endopeptidase activity", "Endopeptidase regulator activity", "Endopolyphosphatase activity", "Endoribonuclease activity", "Endoribonuclease activity producing 3 phosphomonoesters", "Endoribonuclease activity producing 5 phosphomonoesters", "Enoyl coa hydratase activity", "Enzyme activator activity", "Enzyme inhibitor activity", "Enzyme regulator activity", "Ephrin receptor binding", "Epidermal growth factor receptor binding", "Epoxide hydrolase activity", "Er retention sequence binding", "Estradiol 17 beta dehydrogenase activity", "Estrogen receptor binding", "Ether hydrolase activity", "Eukaryotic initiation factor 4e binding", "Exodeoxyribonuclease activity", "Exogenous protein binding", "Exonuclease activity", "Exonuclease activity active with either ribo or deoxyribonucleic acids and producing 5 phosphomonoesters", "Exopeptidase activity", "Exoribonuclease activity", "Exoribonuclease activity producing 5 phosphomonoesters", "Extracellular matrix binding", "Fad binding", "Fatty acid binding", "Fatty acid derivative binding", "Fatty acid ligase activity", "Fatty acid synthase activity", "Fatty acid transmembrane transporter activity", "Fatz binding", "Ferric iron binding", "Ferrous iron binding", "Fibroblast growth factor binding", "Fibronectin binding", "Filamin binding", "Fk506 binding", "Flap endonuclease activity", "Flavin adenine dinucleotide binding", "Flippase activity", "Floppase activity", "Fmn binding", "Folic acid binding", "Folic acid transmembrane transporter activity", "Four way junction dna binding", "Four way junction helicase activity", "Frizzled binding", "Fructose 2 6 bisphosphate 2 phosphatase activity", "Fructose 6 phosphate binding", "Fructose binding", "Fucosyltransferase activity", "G protein activity", "G protein alpha subunit binding", "G protein beta gamma subunit complex binding", "G protein beta subunit binding", "G protein coupled glutamate receptor binding", "G protein coupled opioid receptor activity", "G protein coupled receptor activity", "G protein coupled receptor binding", "G protein coupled serotonin receptor binding", "G quadruplex dna binding", "G quadruplex rna binding", "G rich strand telomeric dna binding", "Gaba receptor binding", "Galactosidase activity", "Galactoside binding", "Galactosyltransferase activity", "Gamma aminobutyric acid transmembrane transporter activity", "Gamma catenin binding", "Gamma tubulin binding", "Ganglioside binding", "Gated channel activity", "Gdp binding", "Gdp dissociation inhibitor activity", "General transcription initiation factor activity", "General transcription initiation factor binding", "Glucocorticoid receptor binding", "Glucose binding", "Glucosidase activity", "Glucosyltransferase activity", "Glucuronosyltransferase activity", "Glutamate receptor binding", "Glutathione disulfide oxidoreductase activity", "Glutathione oxidoreductase activity", "Glutathione peroxidase activity", "Glutathione transferase activity", "Glyceraldehyde 3 phosphate dehydrogenase nadplus non phosphorylating activity", "Glycerophospholipid flippase activity", "Glycine binding", "Glycolipid binding", "Glycolipid mannosyltransferase activity", "Glycosaminoglycan binding", "Glycosphingolipid binding", "Glycosyltransferase activity", "Gpi anchor binding", "Growth factor activity", "Growth factor binding", "Growth factor receptor binding", "Gtp dependent protein binding", "Gtpase activating protein binding", "Gtpase activator activity", "Gtpase activity", "Gtpase binding", "Gtpase inhibitor activity", "Guanyl nucleotide binding", "Guanyl nucleotide exchange factor activity", "Guanylate kinase activity", "Guanylyltransferase activity", "H4 histone acetyltransferase activity", "Heat shock protein binding", "Helicase activity", "Heme transmembrane transporter activity", "Heparan sulfate sulfotransferase activity", "Heparin binding", "Hexokinase activity", "Hexosaminidase activity", "Hexosyltransferase activity", "High density lipoprotein particle binding", "Histone acetyltransferase binding", "Histone arginine n methyltransferase activity", "Histone binding", "Histone deacetylase activity h3 k14 specific", "Histone deacetylase binding", "Histone deacetylase regulator activity", "Histone h3 di monomethyl lysine 9 demethylase activity", "Histone h3 methyl lysine 36 demethylase activity", "Histone h3 methyl lysine 4 demethylase activity", "Histone h3 methyl lysine 9 demethylase activity", "Histone h3 tri di methyl lysine 27 demethylase activity", "Histone kinase activity", "Histone lysine n methyltransferase activity", "Histone methyltransferase activity", "Histone methyltransferase activity h3 k36 specific", "Histone methyltransferase activity h3 k4 specific", "Histone methyltransferase activity h4 k20 specific", "Histone methyltransferase binding", "Histone serine kinase activity", "Histone threonine kinase activity", "Hormone activity", "Hormone binding", "Hormone receptor binding", "Hsp70 protein binding", "Hsp90 protein binding", "Hyaluronic acid binding", "Hyalurononglucosaminidase activity", "Hydro lyase activity", "Hydrolase activity acting on acid anhydrides", "Hydrolase activity acting on carbon nitrogen but not peptide bonds", "Hydrolase activity acting on carbon nitrogen but not peptide bonds in cyclic amides", "Hydrolase activity acting on carbon nitrogen but not peptide bonds in cyclic amidines", "Hydrolase activity acting on carbon nitrogen but not peptide bonds in linear amides", "Hydrolase activity acting on carbon nitrogen but not peptide bonds in linear amidines", "Hydrolase activity acting on ester bonds", "Hydrolase activity acting on ether bonds", "Hydrolase activity acting on glycosyl bonds", "Hydrolase activity hydrolyzing n glycosyl compounds", "Hydrolase activity hydrolyzing o glycosyl compounds", "Hydroxymethyl formyl and related transferase activity", "I smad binding", "Identical protein binding", "Ige binding", "Immunoglobulin binding", "Immunoglobulin receptor binding", "Importin alpha family protein binding", "Inorganic anion transmembrane transporter activity", "Inorganic diphosphatase activity", "Inorganic molecular entity transmembrane transporter activity", "Inorganic phosphate transmembrane transporter activity", "Inositol phosphate phosphatase activity", "Inositol polyphosphate 5 phosphatase activity", "Inositol tetrakisphosphate phosphatase activity", "Inositol trisphosphate phosphatase activity", "Insulin binding", "Insulin like growth factor binding", "Insulin like growth factor ii binding", "Insulin like growth factor receptor binding", "Insulin receptor binding", "Insulin receptor substrate binding", "Integrin binding", "Interleukin 1 receptor binding", "Interleukin 2 receptor binding", "Interleukin 6 receptor binding", "Intermediate filament binding", "Intracellular calcium activated chloride channel activity", "Intraciliary transport particle b binding", "Intramembrane lipid transporter activity", "Intramolecular oxidoreductase activity", "Intramolecular oxidoreductase activity interconverting aldoses and ketoses", "Intramolecular oxidoreductase activity transposing c c bonds", "Intramolecular transferase activity", "Intramolecular transferase activity phosphotransferases", "Intronic transcription regulatory region sequence specific dna binding", "Ion gated channel activity", "Ion transmembrane transporter activity", "Ionotropic glutamate receptor binding", "Iron ion binding", "Isocitrate dehydrogenase activity", "Isomerase activity", "Isopeptidase activity", "Isoprenoid binding", "Jun kinase binding", "Jun kinase kinase kinase activity", "K48 linked polyubiquitin modification dependent protein binding", "K63 linked polyubiquitin modification dependent protein binding", "Keratin filament binding", "Kinase activator activity", "Kinase activity", "Kinase binding", "Kinase inhibitor activity", "Kinase regulator activity", "Kinesin binding", "Kinetochore binding", "L alanine transmembrane transporter activity", "L amino acid transmembrane transporter activity", "L arginine transmembrane transporter activity", "L ascorbic acid binding", "L aspartate transmembrane transporter activity", "L glutamine transmembrane transporter activity", "L histidine transmembrane transporter activity", "L lactate dehydrogenase activity", "L leucine transmembrane transporter activity", "L lysine transmembrane transporter activity", "L ornithine transmembrane transporter activity", "L serine transmembrane transporter activity", "Lactate dehydrogenase activity", "Lactate transmembrane transporter activity", "Lamin binding", "Laminin 1 binding", "Laminin binding", "Large ribosomal subunit rrna binding", "Lbd domain binding", "Leucine binding", "Leucine zipper domain binding", "Leukotriene c4 synthase activity", "Ligand gated ion channel activity", "Ligase activity", "Ligase activity forming carbon carbon bonds", "Ligase activity forming carbon nitrogen bonds", "Ligase activity forming carbon oxygen bonds", "Ligase activity forming carbon sulfur bonds", "Ligase activity forming phosphoric ester bonds", "Lim domain binding", "Lipase activator activity", "Lipase activity", "Lipase binding", "Lipase inhibitor activity", "Lipid binding", "Lipid kinase activity", "Lipid phosphatase activity", "Lipid transfer activity", "Lipid transporter activity", "Lipopolysaccharide binding", "Lipopolysaccharide immune receptor activity", "Lipoprotein particle receptor activity", "Lipoprotein particle receptor binding", "Long chain acyl coa dehydrogenase activity", "Long chain fatty acid binding", "Long chain fatty acid coa ligase activity", "Long chain fatty acid transporter activity", "Long chain fatty acyl coa binding", "Low density lipoprotein particle binding", "Low density lipoprotein particle receptor activity", "Low density lipoprotein particle receptor binding", "Lrr domain binding", "Lyase activity", "Lys48 specific deubiquitinase activity", "Lys63 specific deubiquitinase activity", "Lysine acetylated histone binding", "Lysine n methyltransferase activity", "Lysophosphatidic acid binding", "Lysophosphatidic acid phosphatase activity", "Lysophospholipase activity", "Lysophospholipid acyltransferase activity", "M7g 5 pppn diphosphatase activity", "Macrolide binding", "Macromolecule transmembrane transporter activity", "Magnesium ion binding", "Magnesium ion transmembrane transporter activity", "Malate dehydrogenase activity", "Manganese ion binding", "Manganese ion transmembrane transporter activity", "Mannose binding", "Mannosyltransferase activity", "Map kinase activity", "Map kinase kinase activity", "Map kinase kinase kinase activity", "Map kinase phosphatase activity", "Map kinase scaffold activity", "Map kinase tyrosine serine threonine phosphatase activity", "Mdm2 mdm4 family protein binding", "Medium chain fatty acid coa ligase activity", "Membrane insertase activity", "Metal cluster binding", "Metal dependent deubiquitinase activity", "Metal ion proton antiporter activity", "Metal ion transmembrane transporter activity", "Metalloaminopeptidase activity", "Metallocarboxypeptidase activity", "Metallochaperone activity", "Metallodipeptidase activity", "Metalloendopeptidase activity", "Metalloexopeptidase activity", "Metallopeptidase activity", "Methyl cpg binding", "Methylated histone binding", "Mhc class i protein binding", "Mhc class ib protein binding", "Mhc class ii protein complex binding", "Mhc protein binding", "Mhc protein complex binding", "Microfilament motor activity", "Microtubule binding", "Microtubule minus end binding", "Microtubule motor activity", "Microtubule plus end binding", "Minor groove of adenine thymine rich dna binding", "Minus end directed microtubule motor activity", "Mirna binding", "Misfolded protein binding", "Mismatch repair complex binding", "Mismatched dna binding", "Mitochondrial ribosome binding", "Mitochondrion targeting sequence binding", "Mitogen activated protein kinase binding", "Mitogen activated protein kinase kinase binding", "Mitogen activated protein kinase kinase kinase binding", "Mitogen activated protein kinase p38 binding", "Modification dependent protein binding", "Modified amino acid binding", "Modified amino acid transmembrane transporter activity", "Molecular adaptor activity", "Molecular carrier activity", "Molecular function activator activity", "Molecular function inhibitor activity", "Molecular function regulator", "Molecular sequestering activity", "Molecular transducer activity", "Molybdopterin cofactor binding", "Monocarboxylic acid binding", "Monocarboxylic acid transmembrane transporter activity", "Monooxygenase activity", "Monosaccharide binding", "Mrf binding", "Mrna 3 utr au rich region binding", "Mrna 3 utr binding", "Mrna 5 utr binding", "Mrna binding", "Mrna methyltransferase activity", "Muscle alpha actinin binding", "Mutlalpha complex binding", "Myosin binding", "Myosin ii binding", "Myosin v binding", "Myristoyltransferase activity", "N acetylgalactosamine 4 o sulfotransferase activity", "N acetyllactosaminide beta 1 3 n acetylglucosaminyltransferase activity", "N acetyltransferase activity", "N acylsphingosine amidohydrolase activity", "N acyltransferase activity", "N methyltransferase activity", "N6 methyladenosine containing rna binding", "Nad binding", "Nad dependent protein deacetylase activity", "Nad p h oxidase h2o2 forming activity", "Nad retinol dehydrogenase activity", "Nadh dehydrogenase activity", "Nadh pyrophosphatase activity", "Nadp binding", "Nadp retinol dehydrogenase activity", "Nadph binding", "Nadplus adp ribosyltransferase activity", "Nadplus binding", "Nadplus kinase activity", "Nedd8 specific protease activity", "Nedd8 transferase activity", "Nerve growth factor binding", "Neurexin family protein binding", "Neuroligin family protein binding", "Neurotransmitter transmembrane transporter activity", "Neurotrophin binding", "Neurotrophin receptor activity", "Neurotrophin receptor binding", "Neurotrophin trk receptor binding", "Neutral amino acid transmembrane transporter activity", "Nf kappab binding", "Nfat protein binding", "Nitric oxide synthase binding", "Nitric oxide synthase regulator activity", "Nitrite reductase activity", "Non membrane spanning protein tyrosine kinase activity", "Non membrane spanning protein tyrosine phosphatase activity", "Notch binding", "Nuclear export signal receptor activity", "Nuclear import signal receptor activity", "Nuclear localization sequence binding", "Nuclear receptor activity", "Nuclear receptor binding", "Nuclear receptor coactivator activity", "Nuclease activity", "Nucleobase containing compound kinase activity", "Nucleobase containing compound transmembrane transporter activity", "Nucleobase transmembrane transporter activity", "Nucleocytoplasmic carrier activity", "Nucleoside binding", "Nucleoside diphosphatase activity", "Nucleoside diphosphate kinase activity", "Nucleoside kinase activity", "Nucleoside monophosphate kinase activity", "Nucleoside transmembrane transporter activity", "Nucleoside triphosphatase regulator activity", "Nucleoside triphosphate diphosphatase activity", "Nucleosomal dna binding", "Nucleosome binding", "Nucleotidase activity", "Nucleotide diphosphatase activity", "Nucleotide phosphatase activity acting on free nucleotides", "Nucleotide sugar transmembrane transporter activity", "Nucleotide transmembrane transporter activity", "Nucleotidyltransferase activity", "O acetyltransferase activity", "O acyltransferase activity", "O methyltransferase activity", "O palmitoyltransferase activity", "Oleate transmembrane transporter activity", "Oligopeptide binding", "Oligosaccharide binding", "Oligosaccharyl transferase activity", "Omega peptidase activity", "Opsonin binding", "Organic acid binding", "Organic acid transmembrane transporter activity", "Organic anion transmembrane transporter activity", "Organic cation transmembrane transporter activity", "Organic hydroxy compound transmembrane transporter activity", "Organophosphate ester transmembrane transporter activity", "Oxidative phosphorylation uncoupler activity", "Oxidative rna demethylase activity", "Oxidized dna binding", "Oxidoreductase activity", "Oxidoreductase activity acting on a heme group of donors", "Oxidoreductase activity acting on a sulfur group of donors", "Oxidoreductase activity acting on a sulfur group of donors disulfide as acceptor", "Oxidoreductase activity acting on a sulfur group of donors nad p as acceptor", "Oxidoreductase activity acting on a sulfur group of donors oxygen as acceptor", "Oxidoreductase activity acting on ch oh group of donors", "Oxidoreductase activity acting on ch or ch2 groups", "Oxidoreductase activity acting on diphenols and related substances as donors", "Oxidoreductase activity acting on nad p h", "Oxidoreductase activity acting on nad p h heme protein as acceptor", "Oxidoreductase activity acting on nad p h oxygen as acceptor", "Oxidoreductase activity acting on nad p h quinone or similar compound as acceptor", "Oxidoreductase activity acting on other nitrogenous compounds as donors", "Oxidoreductase activity acting on other nitrogenous compounds as donors cytochrome as acceptor", "Oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen", "Oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen nad p h as one donor and incorporation of one atom of oxygen", "Oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen reduced flavin or flavoprotein as one donor and incorporation of one atom of oxygen", "Oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen reduced pteridine as one donor and incorporation of one atom of oxygen", "Oxidoreductase activity acting on paired donors with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water", "Oxidoreductase activity acting on peroxide as acceptor", "Oxidoreductase activity acting on single donors with incorporation of molecular oxygen", "Oxidoreductase activity acting on the aldehyde or oxo group of donors", "Oxidoreductase activity acting on the aldehyde or oxo group of donors disulfide as acceptor", "Oxidoreductase activity acting on the aldehyde or oxo group of donors nad or nadp as acceptor", "Oxidoreductase activity acting on the ch ch group of donors", "Oxidoreductase activity acting on the ch ch group of donors nad or nadp as acceptor", "Oxidoreductase activity acting on the ch ch group of donors oxygen as acceptor", "Oxidoreductase activity acting on the ch nh group of donors", "Oxidoreductase activity acting on the ch nh group of donors nad or nadp as acceptor", "Oxidoreductase activity acting on the ch nh2 group of donors", "Oxidoreduction driven active transmembrane transporter activity", "Oxo acid lyase activity", "Oxygen binding", "Oxygen sensor activity", "Oxysterol binding", "P type calcium transporter activity", "P type potassium transmembrane transporter activity", "P type transmembrane transporter activity", "P53 binding", "Palmitoyl coa hydrolase activity", "Palmitoyl protein hydrolase activity", "Palmitoyltransferase activity", "Passive transmembrane transporter activity", "Patched binding", "Pattern recognition receptor activity", "Pdz domain binding", "Pentosyltransferase activity", "Peptidase activator activity", "Peptidase activator activity involved in apoptotic process", "Peptidase activity", "Peptidase regulator activity", "Peptide alpha n acetyltransferase activity", "Peptide antigen binding", "Peptide binding", "Peptide hormone binding", "Peptide hormone receptor binding", "Peptide lysine n acetyltransferase activity", "Peptide n acetyltransferase activity", "Peptide receptor activity", "Peptidoglycan binding", "Peptidyl proline 4 dioxygenase activity", "Peptidyl proline dioxygenase activity", "Peroxiredoxin activity", "Peroxisome proliferator activated receptor binding", "Peroxisome targeting sequence binding", "Phosphatase activator activity", "Phosphatase activity", "Phosphatase binding", "Phosphatase inhibitor activity", "Phosphatase regulator activity", "Phosphate ion binding", "Phosphatidic acid binding", "Phosphatidyl phospholipase b activity", "Phosphatidylcholine binding", "Phosphatidylcholine floppase activity", "Phosphatidylcholine transfer activity", "Phosphatidylcholine transporter activity", "Phosphatidylethanolamine binding", "Phosphatidylethanolamine flippase activity", "Phosphatidylglycerol binding", "Phosphatidylinositol 3 4 5 trisphosphate 3 phosphatase activity", "Phosphatidylinositol 3 4 5 trisphosphate 5 phosphatase activity", "Phosphatidylinositol 3 4 5 trisphosphate binding", "Phosphatidylinositol 3 5 bisphosphate binding", "Phosphatidylinositol 3 kinase activity", "Phosphatidylinositol 3 kinase binding", "Phosphatidylinositol 3 kinase regulator activity", "Phosphatidylinositol 3 kinase regulatory subunit binding", "Phosphatidylinositol 3 phosphate binding", "Phosphatidylinositol 4 5 bisphosphate 5 phosphatase activity", "Phosphatidylinositol 4 5 bisphosphate binding", "Phosphatidylinositol 4 5 bisphosphate phosphatase activity", "Phosphatidylinositol 4 phosphate binding", "Phosphatidylinositol 5 phosphate binding", "Phosphatidylinositol binding", "Phosphatidylinositol bisphosphate binding", "Phosphatidylinositol bisphosphate phosphatase activity", "Phosphatidylinositol kinase activity", "Phosphatidylinositol monophosphate phosphatase activity", "Phosphatidylinositol phosphate 4 phosphatase activity", "Phosphatidylinositol phosphate 5 phosphatase activity", "Phosphatidylinositol phosphate binding", "Phosphatidylinositol phosphate kinase activity", "Phosphatidylinositol phosphate phosphatase activity", "Phosphatidylinositol transfer activity", "Phosphatidylinositol trisphosphate phosphatase activity", "Phosphatidylserine 1 acylhydrolase activity", "Phosphatidylserine binding", "Phosphodiesterase i activity", "Phosphofructokinase activity", "Phospholipase a1 activity", "Phospholipase a2 activity", "Phospholipase a2 inhibitor activity", "Phospholipase activity", "Phospholipase binding", "Phospholipase c activity", "Phospholipase d activity", "Phospholipase inhibitor activity", "Phospholipid binding", "Phospholipid scramblase activity", "Phospholipid transfer activity", "Phospholipid transporter activity", "Phosphoprotein binding", "Phosphoprotein phosphatase activity", "Phosphoric diester hydrolase activity", "Phosphoric ester hydrolase activity", "Phosphorus oxygen lyase activity", "Phosphoserine residue binding", "Phosphotransferase activity for other substituted phosphate groups", "Phosphotransferase activity nitrogenous group as acceptor", "Phosphotransferase activity phosphate group as acceptor", "Phosphotyrosine residue binding", "Plus end directed microtubule motor activity", "Poly a binding", "Poly a specific ribonuclease activity", "Poly g binding", "Poly purine tract binding", "Poly pyrimidine tract binding", "Polynucleotide adenylyltransferase activity", "Polypeptide n acetylgalactosaminyltransferase activity", "Polysaccharide binding", "Polysome binding", "Polyubiquitin modification dependent protein binding", "Porin activity", "Potassium channel inhibitor activity", "Potassium channel regulator activity", "Potassium ion binding", "Potassium ion transmembrane transporter activity", "Pre mirna binding", "Pre mrna 3 splice site binding", "Pre mrna 5 splice site binding", "Pre mrna binding", "Pre mrna intronic binding", "Prenyltransferase activity", "Primary active transmembrane transporter activity", "Primary mirna binding", "Procollagen proline 4 dioxygenase activity", "Procollagen proline dioxygenase activity", "Profilin binding", "Proline rich region binding", "Promoter specific chromatin binding", "Protease binding", "Proteasome activating activity", "Proteasome binding", "Protein adp ribosylase activity", "Protein antigen binding", "Protein arginine n methyltransferase activity", "Protein arginine omega n asymmetric methyltransferase activity", "Protein arginine omega n monomethyltransferase activity", "Protein binding involved in heterotypic cell cell adhesion", "Protein c terminus binding", "Protein carboxyl o methyltransferase activity", "Protein carrier chaperone", "Protein containing complex binding", "Protein deacetylase activity", "Protein demethylase activity", "Protein dimerization activity", "Protein disaggregase activity", "Protein disulfide isomerase activity", "Protein disulfide reductase nad p activity", "Protein domain specific binding", "Protein folding chaperone", "Protein heterodimerization activity", "Protein homodimerization activity", "Protein kinase a binding", "Protein kinase a catalytic subunit binding", "Protein kinase a regulatory subunit binding", "Protein kinase activity", "Protein kinase b binding", "Protein kinase c activity", "Protein kinase c binding", "Protein lipid complex binding", "Protein macromolecule adaptor activity", "Protein membrane adaptor activity", "Protein methyltransferase activity", "Protein n terminus binding", "Protein phosphatase 1 binding", "Protein phosphatase 2a binding", "Protein phosphatase activator activity", "Protein phosphatase binding", "Protein phosphatase regulator activity", "Protein phosphorylated amino acid binding", "Protein prenyltransferase activity", "Protein self association", "Protein sequestering activity", "Protein serine kinase activity", "Protein serine threonine kinase activator activity", "Protein serine threonine kinase activity", "Protein serine threonine kinase inhibitor activity", "Protein serine threonine phosphatase activity", "Protein serine threonine phosphatase inhibitor activity", "Protein serine threonine tyrosine kinase activity", "Protein transmembrane transporter activity", "Protein transporter activity", "Protein tyrosine kinase activator activity", "Protein tyrosine kinase activity", "Protein tyrosine kinase binding", "Protein tyrosine kinase inhibitor activity", "Protein tyrosine phosphatase activity", "Protein tyrosine serine threonine phosphatase activity", "Protein tyrosine threonine phosphatase activity", "Proteoglycan binding", "Proton channel activity", "Proton transmembrane transporter activity", "Proton transporting atp synthase activity rotational mechanism", "Pseudouridine synthase activity", "Purine nucleotide transmembrane transporter activity", "Pyrimidine nucleoside transmembrane transporter activity", "Pyrimidine nucleotide binding", "Pyrimidine nucleotide sugar transmembrane transporter activity", "Pyrophosphate hydrolysis driven proton transmembrane transporter activity", "Pyruvate dehydrogenase acetyl transferring kinase activity", "Pyruvate dehydrogenase activity", "Quaternary ammonium group binding", "Quaternary ammonium group transmembrane transporter activity", "Quinone binding", "R smad binding", "Racemase and epimerase activity", "Rage receptor binding", "Rdna binding", "Receptor antagonist activity", "Receptor tyrosine kinase binding", "Regulatory rna binding", "Retinal dehydrogenase activity", "Retinoic acid binding", "Retinoic acid receptor binding", "Retinoid x receptor binding", "Retromer complex binding", "Ribonuclease activity", "Ribonuclease p activity", "Ribonuclease p rna binding", "Ribonucleoprotein complex binding", "Ribonucleotide binding", "Ribose phosphate diphosphokinase activity", "Ribosomal large subunit binding", "Ribosomal protein s6 kinase activity", "Ribosomal small subunit binding", "Ribosome binding", "Rna 2 o methyltransferase activity", "Rna 7 methylguanosine cap binding", "Rna adenylyltransferase activity", "Rna binding", "Rna binding involved in posttranscriptional gene silencing", "Rna cap binding", "Rna directed dna polymerase activity", "Rna dna hybrid ribonuclease activity", "Rna methyltransferase activity", "Rna polymerase activity", "Rna polymerase binding", "Rna polymerase core enzyme binding", "Rna polymerase i general transcription initiation factor activity", "Rna polymerase i transcription regulatory region sequence specific dna binding", "Rna polymerase ii activity", "Rna polymerase ii c terminal domain binding", "Rna polymerase ii c terminal domain phosphoserine binding", "Rna polymerase ii core promoter sequence specific dna binding", "Rna polymerase ii ctd heptapeptide repeat kinase activity", "Rna polymerase ii ctd heptapeptide repeat phosphatase activity", "Rna polymerase ii general transcription initiation factor activity", "Rna polymerase ii general transcription initiation factor binding", "Rna polymerase ii intronic transcription regulatory region sequence specific dna binding", "Rna polymerase ii specific dna binding transcription factor binding", "Rna polymerase iii transcription regulatory region sequence specific dna binding", "Rna stem loop binding", "Rna strand annealing activity", "Roundabout binding", "Rrna binding", "Rrna cytosine methyltransferase activity", "S acyltransferase activity", "S adenosyl l methionine binding", "S adenosylmethionine dependent methyltransferase activity", "S methyltransferase activity", "S100 protein binding", "Scaffold protein binding", "Scavenger receptor activity", "Secondary active transmembrane transporter activity", "Semaphorin receptor activity", "Sequence specific dna binding", "Sequence specific mrna binding", "Sequence specific single stranded dna binding", "Serine hydrolase activity", "Serine transmembrane transporter activity", "Serine type carboxypeptidase activity", "Serine type endopeptidase inhibitor activity", "Serine type exopeptidase activity", "Sh2 domain binding", "Sh3 domain binding", "Signal recognition particle binding", "Signal sequence binding", "Signaling adaptor activity", "Signaling receptor binding", "Signaling receptor complex adaptor activity", "Signaling receptor inhibitor activity", "Signaling receptor regulator activity", "Single stranded dna 3 5 exodeoxyribonuclease activity", "Single stranded dna binding", "Single stranded dna endodeoxyribonuclease activity", "Single stranded dna exodeoxyribonuclease activity", "Single stranded dna helicase activity", "Single stranded rna binding", "Single stranded telomeric dna binding", "Sirna binding", "Smad binding", "Small molecule sensor activity", "Small protein activating enzyme binding", "Small ribosomal subunit rrna binding", "Snap receptor activity", "Snare binding", "Snorna binding", "Snrna binding", "Snrnp binding", "Sodium channel regulator activity", "Sodium ion binding", "Sodium ion transmembrane transporter activity", "Solute anion antiporter activity", "Solute cation antiporter activity", "Solute cation symporter activity", "Solute proton antiporter activity", "Solute proton symporter activity", "Spectrin binding", "Sphingolipid binding", "Sphingolipid transfer activity", "Sphingolipid transporter activity", "Sphingomyelin phosphodiesterase activity", "Sphingosine n acyltransferase activity", "Steroid binding", "Steroid dehydrogenase activity", "Steroid dehydrogenase activity acting on the ch oh group of donors nad or nadp as acceptor", "Steroid hormone binding", "Steroid hormone receptor activity", "Sterol binding", "Sterol esterase activity", "Sterol transfer activity", "Sterol transporter activity", "Structural constituent of cytoskeleton", "Structural constituent of eye lens", "Structural constituent of muscle", "Structural constituent of nuclear pore", "Structural constituent of postsynapse", "Structural constituent of postsynaptic actin cytoskeleton", "Structural constituent of presynaptic active zone", "Structural constituent of ribosome", "Structural constituent of synapse", "Structural molecule activity", "Structural molecule activity conferring elasticity", "Succinate transmembrane transporter activity", "Sugar transmembrane transporter activity", "Sulfate binding", "Sulfate transmembrane transporter activity", "Sulfatide binding", "Sulfotransferase activity", "Sulfur compound binding", "Sulfur compound transmembrane transporter activity", "Sulfuric ester hydrolase activity", "Sulfurtransferase activity", "Sumo binding", "Sumo ligase activity", "Sumo specific protease activity", "Sumo transferase activity", "Supercoiled dna binding", "Superoxide dismutase activity", "Symporter activity", "Syntaxin 1 binding", "Syntaxin binding", "T cell receptor binding", "Tap binding", "Tat protein binding", "Tau protein binding", "Tau protein kinase activity", "Tbp class protein binding", "Telomerase activity", "Telomerase inhibitor activity", "Telomerase rna binding", "Telomeric dna binding", "Testosterone dehydrogenase nad p activity", "Testosterone dehydrogenase nadplus activity", "Tetrapyrrole binding", "Tfiib class transcription factor binding", "Tfiid class transcription factor complex binding", "Thiamine pyrophosphate binding", "Thioesterase binding", "Thiol oxidase activity", "Thiolester hydrolase activity", "Thioredoxin disulfide reductase activity", "Threonine type endopeptidase activity", "Threonine type peptidase activity", "Thyroid hormone receptor binding", "Titin binding", "Toll like receptor binding", "Toxic substance binding", "Tpr domain binding", "Transcription coactivator activity", "Transcription coactivator binding", "Transcription coregulator activity", "Transcription coregulator binding", "Transcription corepressor activity", "Transcription corepressor binding", "Transcription elongation regulator activity", "Transcription factor binding", "Transcription regulator activity", "Transcription regulator inhibitor activity", "Transferase activity transferring alkyl or aryl other than methyl groups", "Transferase activity transferring nitrogenous groups", "Transferase activity transferring one carbon groups", "Transferase activity transferring phosphorus containing groups", "Transferase activity transferring sulphur containing groups", "Transferrin receptor binding", "Transforming growth factor beta receptor binding", "Transition metal ion binding", "Transition metal ion transmembrane transporter activity", "Transketolase or transaldolase activity", "Translation activator activity", "Translation elongation factor activity", "Translation factor activity rna binding", "Translation initiation factor activity", "Translation initiation factor binding", "Translation regulator activity", "Translation regulator activity nucleic acid binding", "Translation repressor activity", "Translation repressor activity mrna regulatory element binding", "Translation termination factor activity", "Transmembrane receptor protein kinase activity", "Transmembrane receptor protein tyrosine kinase activity", "Transmembrane transporter binding", "Transporter activity", "Triglyceride lipase activity", "Trna binding", "Trna cytosine methyltransferase activity", "Trna guanine methyltransferase activity", "Trna methyltransferase activity", "Trna specific adenosine deaminase activity", "Trna specific ribonuclease activity", "Tropomyosin binding", "Tubulin binding", "Tumor necrosis factor activated receptor activity", "Tumor necrosis factor receptor binding", "Tumor necrosis factor receptor superfamily binding", "Type i transforming growth factor beta receptor binding", "U1 snrna binding", "U2 snrna binding", "U3 snorna binding", "U4 snrna binding", "U6 snrna binding", "Ubiquinol cytochrome c reductase activity", "Ubiquinone binding", "Ubiquitin binding", "Ubiquitin conjugating enzyme binding", "Ubiquitin ligase substrate adaptor activity", "Ubiquitin like modifier activating enzyme activity", "Ubiquitin like protein binding", "Ubiquitin like protein conjugating enzyme activity", "Ubiquitin like protein conjugating enzyme binding", "Ubiquitin like protein ligase activity", "Ubiquitin like protein ligase binding", "Ubiquitin like protein specific isopeptidase activity", "Ubiquitin like protein specific protease activity", "Ubiquitin like protein transferase activity", "Ubiquitin protein transferase activator activity", "Ubiquitin protein transferase inhibitor activity", "Ubiquitin protein transferase regulator activity", "Ubiquitin specific protease binding", "Ubiquitin ubiquitin ligase activity", "Ubiquitination like modification dependent protein binding", "Udp galactose beta n acetylglucosamine beta 1 3 galactosyltransferase activity", "Udp glucosyltransferase activity", "Udp glycosyltransferase activity", "Udp xylosyltransferase activity", "Unfolded protein binding", "Unmethylated cpg binding", "Uridine transmembrane transporter activity", "Uridylyltransferase activity", "Vascular endothelial growth factor receptor 2 binding", "Vascular endothelial growth factor receptor binding", "Very long chain fatty acid coa ligase activity", "Vinculin binding", "Virion binding", "Vitamin b6 binding", "Vitamin binding", "Vitamin d binding", "Vitamin d receptor binding", "Vitamin transmembrane transporter activity", "Voltage gated anion channel activity", "Voltage gated channel activity", "Voltage gated chloride channel activity", "Volume sensitive anion channel activity", "Water channel activity", "Water transmembrane transporter activity", "Wd40 repeat domain binding", "Wide pore channel activity", "Ww domain binding", "Xenobiotic transmembrane transporter activity", "Zinc ion binding"], "available_proteins": ["AARS", "AARS2", "AARSD1", "AASDHPPT", "AASS", "AATF", "ABCB1", "ABCB10", "ABCB7", "ABCD3", "ABCE1", "ABCF1", "ABCF2", "ABHD10", "ABHD12", "ABHD6", "ACAA2", "ACACA", "ACACB", "ACAD9", "ACADM", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACBD5", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT8", "ACOT9", "ACOX1", "ACOX3", "ACP1", "ACP2", "ACP6", "ACSL1", "ACSL3", "ACSL4", "ACTN1", "ACTN2", "ACTN4", "ACTR1A", "ACTR2", "ACTR3", "ADA", "ADAR", "ADD1", "ADD3", "ADH5", "ADI1", "ADK", "ADNP", "ADPGK", "ADPRHL2", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGK", "AGL", "AGPAT1", "AGPS", "AHCY", "AHCYL1", "AHNAK", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AK4", "AK6", "AKAP12", "AKAP13", "AKAP8", "AKAP8L", "AKR1A1", "AKR1B1", "AKR7A2", "AKT2", "ALDH18A1", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALG1", "ALKBH5", "ALYREF", "AMOT", "ANAPC1", "ANAPC4", "ANAPC5", "ANAPC7", "ANK3", "ANKFY1", "ANKHD1", "ANKLE2", "ANLN", "ANP32A", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP1M1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3M1", "APC", "APEH", "APEX1", "API5", "APMAP", "APOL2", "APP", "APPL1", "APRT", "AQR", "ARCN1", "ARF4", "ARF5", "ARFGAP1", "ARFIP1", "ARFIP2", "ARHGAP17", "ARHGDIA", "ARHGEF1", "ARHGEF2", "ARID1A", "ARIH1", "ARL1", "ARL2", "ARL3", "ARL6IP1", "ARL8B", "ARMT1", "ARPC1A", "ARPC2", "ARPC3", "ARPC4", "ARPC5", "ASAH1", "ASCC3", "ASF1A", "ASNA1", "ASNS", "ASPH", "ATAD1", "ATAD3A", "ATAD3B", "ATAD5", "ATE1", "ATG7", "ATIC", "ATL2", "ATP13A1", "ATP1A1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5L", "ATP5O", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1D", "ATP6V1E1", "ATP6V1H", "ATPIF1", "ATXN2L", "AUP1", "AURKA", "B3GALT6", "B4GAT1", "BAG2", "BAG4", "BAG5", "BAG6", "BAIAP2", "BAK1", "BANF1", "BAP18", "BASP1", "BAZ1A", "BAZ1B", "BCAP31", "BCAS3", "BCCIP", "BCL2L13", "BCLAF1", "BCS1L", "BDH2", "BICD2", "BIRC6", "BLMH", "BLVRA", "BLVRB", "BMS1", "BNIP1", "BOP1", "BPNT1", "BPTF", "BRD4", "BRIX1", "BSG", "BTAF1", "BTF3", "BUB1", "BUB1B", "BUB3", "BUD31", "BYSL", "BZW1", "BZW2", "C1QBP", "C1orf35", "CACYBP", "CAD", "CALD1", "CALM3", "CALR", "CALU", "CAMK2G", "CAND1", "CANX", "CAP1", "CAPN1", "CAPNS1", "CAPRIN1", "CAPZA1", "CAPZB", "CARHSP1", "CARM1", "CARS", "CARS2", "CASK", "CASP3", "CASP6", "CASP7", "CASP8", "CAST", "CBR1", "CBX1", "CBX3", "CBX5", "CBX8", "CCAR1", "CCAR2", "CCDC124", "CCDC137", "CCDC22", "CCDC47", "CCDC6", "CCDC86", "CCNB1", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2AP", "CD2BP2", "CD3EAP", "CD47", "CDC23", "CDC27", "CDC37", "CDC40", "CDC42", "CDC45", "CDC5L", "CDC73", "CDCA5", "CDIPT", "CDK1", "CDK12", "CDK2", "CDK4", "CDK5RAP3", "CDK6", "CDKN2AIP", "CDS2", "CDX2", "CEBPZ", "CELF1", "CENPV", "CEP44", "CEP55", "CERS1", "CERS2", "CETN2", "CFAP20", "CFL1", "CFL2", "CGGBP1", "CHAC2", "CHAF1B", "CHAMP1", "CHCHD3", "CHD1", "CHD4", "CHEK2", "CHERP", "CHID1", "CHKA", "CHML", "CHMP1A", "CHMP2B", "CHMP5", "CHMP6", "CHORDC1", "CHRAC1", "CHST14", "CIAPIN1", "CIP2A", "CIRBP", "CISD1", "CISD2", "CIZ1", "CKAP4", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLCC1", "CLCN3", "CLGN", "CLIC1", "CLIC4", "CLINT1", "CLN5", "CLNS1A", "CLPB", "CLPP", "CLPX", "CLTA", "CLTC", "CLUH", "CMPK1", "CMSS1", "CNDP2", "CNN2", "CNN3", "CNNM3", "CNNM4", "CNOT1", "CNOT7", "CNOT9", "CNP", "COASY", "COG2", "COIL", "COLEC12", "COLGALT1", "COMT", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS2", "COPS4", "COPS5", "COPS6", "COQ8A", "COQ9", "CORO1B", "CORO1C", "COTL1", "COX15", "COX2", "COX4I1", "COX5A", "COX5B", "COX7A2", "CPD", "CPNE1", "CPNE3", "CPOX", "CPPED1", "CPSF1", "CPSF2", "CPSF3", "CPSF6", "CPSF7", "CPT1A", "CPT2", "CPVL", "CRKL", "CRMP1", "CRNKL1", "CRTAP", "CRYZ", "CS", "CSDE1", "CSE1L", "CSK", "CSNK1A1", "CSNK2A2", "CSNK2B", "CSTB", "CSTF1", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTDSPL2", "CTNNA1", "CTNNB1", "CTNND1", "CTPS1", "CTPS2", "CTR9", "CTSA", "CTSC", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4A", "CUL4B", "CUL5", "CUTA", "CWF19L1", "CXorf57", "CYB5B", "CYB5D2", "CYB5R3", "CYC1", "CYFIP1", "CYP20A1", "CYP51A1", "DAD1", "DAGLB", "DAP3", "DARS", "DARS2", "DAZAP1", "DBN1", "DBNL", "DCAF1", "DCAF13", "DCAF7", "DCAKD", "DCD", "DCP1A", "DCPS", "DCTD", "DCTN1", "DCTN2", "DCTN3", "DCTN4", "DCTN6", "DCTPP1", "DCUN1D4", "DCUN1D5", "DCXR", "DDAH1", "DDB1", "DDI2", "DDOST", "DDRGK1", "DDT", "DDX1", "DDX10", "DDX17", "DDX18", "DDX20", "DDX21", "DDX23", "DDX24", "DDX27", "DDX28", "DDX39A", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX50", "DDX51", "DDX52", "DDX54", "DDX55", "DDX56", "DDX6", "DEK", "DENR", "DERL1", "DFFA", "DHCR24", "DHCR7", "DHFR", "DHPS", "DHRS7B", "DHX15", "DHX16", "DHX30", "DHX36", "DHX37", "DHX38", "DHX8", "DHX9", "DIAPH1", "DIAPH3", "DICER1", "DIDO1", "DIEXF", "DIP2B", "DIS3", "DKC1", "DLAT", "DLD", "DLST", "DNAAF5", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJC1", "DNAJC10", "DNAJC2", "DNAJC3", "DNAJC7", "DNAJC8", "DNAJC9", "DNM1L", "DNM2", "DNMT1", "DNPH1", "DNTTIP2", "DOCK7", "DOHH", "DOLPP1", "DPF2", "DPH2", "DPH5", "DPP3", "DPP9", "DPYSL2", "DPYSL3", "DRG1", "DRG2", "DSG2", "DSP", "DST", "DSTN", "DTL", "DTYMK", "DUSP3", "DUSP9", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNLL1", "DYNLL2", "EARS2", "EBNA1BP2", "EBP", "ECD", "ECE1", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "EDC3", "EDF1", "EEA1", "EEF1A2", "EEF1B2", "EEF1D", "EEF1G", "EEF2", "EEFSEC", "EFL1", "EFTUD2", "EHD1", "EHD4", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2D", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAC2", "ELAVL1", "ELOB", "ELOC", "ELP1", "ELP2", "ELP3", "EMC1", "EMC2", "EMC3", "EMC4", "EMD", "EMG1", "EML4", "ENAH", "ENDOD1", "ENO1", "ENSA", "EPB41", "EPB41L2", "EPB41L3", "EPHX1", "EPHX2", "EPPK1", "EPRS", "EPS15", "EPS15L1", "ERAL1", "ERAP1", "ERCC2", "ERCC3", "ERGIC3", "ERH", "ERLIN1", "ERLIN2", "ERMP1", "ERO1A", "ERP29", "ERP44", "ESD", "ESF1", "ESYT1", "ESYT2", "ETF1", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXO1", "EXOC1", "EXOC2", "EXOC4", "EXOC5", "EXOSC10", "EXOSC3", "EXOSC4", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC8", "EZR", "F11R", "FABP5", "FADS2", "FAF1", "FAF2", "FAHD1", "FAM120A", "FAM208A", "FAM213A", "FAM3C", "FAM49B", "FAM50A", "FAM98A", "FAM98B", "FANCI", "FAR1", "FARSA", "FARSB", "FASN", "FASTKD2", "FAU", "FBL", "FBXO22", "FBXO7", "FDFT1", "FDPS", "FDX1", "FDXR", "FECH", "FEN1", "FERMT2", "FGFR1OP", "FH", "FHL1", "FHOD1", "FIP1L1", "FIS1", "FKBP10", "FKBP14", "FKBP1A", "FKBP3", "FKBP4", "FKBP5", "FKBP7", "FKBP8", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FMR1", "FN3KRP", "FNDC3A", "FNTB", "FOXC1", "FOXRED1", "FSCN1", "FTO", "FTSJ1", "FTSJ3", "FUBP1", "FUBP3", "FUCA1", "FUCA2", "FUNDC2", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GALK1", "GALNT2", "GALNT7", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GATAD2B", "GATB", "GATC", "GBA", "GBE1", "GBF1", "GCAT", "GCC2", "GCDH", "GCLM", "GCN1", "GDI1", "GDI2", "GDPD1", "GEMIN4", "GEMIN5", "GET4", "GFM1", "GFPT1", "GGA1", "GGCT", "GGCX", "GGH", "GHDC", "GIGYF2", "GLA", "GLB1", "GLDC", "GLG1", "GLMN", "GLO1", "GLOD4", "GLRX3", "GLRX5", "GLS", "GLUD1", "GLYR1", "GM2A", "GMDS", "GMFB", "GMPPA", "GMPPB", "GMPS", "GNA13", "GNAI1", "GNAI2", "GNAI3", "GNL1", "GNL2", "GNL3", "GNL3L", "GNPDA1", "GNS", "GOLGA3", "GOLGB1", "GOLPH3", "GOT1", "GOT2", "GPAM", "GPATCH4", "GPATCH8", "GPD2", "GPHN", "GPI", "GPKOW", "GPR107", "GPR89B", "GPS1", "GPT2", "GPX8", "GRB2", "GRHPR", "GRPEL1", "GRSF1", "GRWD1", "GSK3A", "GSK3B", "GSPT1", "GSR", "GSS", "GSTK1", "GSTM3", "GSTO1", "GSTZ1", "GTF2B", "GTF2E1", "GTF2F1", "GTF2F2", "GTF2I", "GTPBP1", "GTPBP10", "GTPBP3", "GTPBP4", "GUSB", "GYG1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACD3", "HADH", "HADHA", "HADHB", "HAT1", "HAUS4", "HBS1L", "HCCS", "HCFC1", "HDAC2", "HDGF", "HDGFL2", "HDHD2", "HDLBP", "HEATR1", "HEATR3", "HEATR6", "HEBP1", "HECTD1", "HELLS", "HEXA", "HEXB", "HGS", "HIBADH", "HIBCH", "HINT2", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HLTF", "HM13", "HMBS", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMGCL", "HMGCS1", "HMOX1", "HMOX2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HNRNPUL2", "HOOK3", "HP1BP3", "HPRT1", "HS2ST1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSDL1", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA14", "HSPA1B", "HSPA2", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPB1", "HSPBP1", "HSPD1", "HSPE1", "HSPH1", "HTATSF1", "HTT", "HUWE1", "HYOU1", "IARS", "IARS2", "IBA57", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDI1", "IFIT5", "IFT27", "IGBP1", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IK", "ILF2", "ILF3", "ILK", "ILKAP", "ILVBL", "IMMT", "IMP3", "IMPDH1", "IMPDH2", "INA", "INF2", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IRGQ", "IRS4", "IST1", "ISYNA1", "ITCH", "ITGB1", "ITPA", "IVD", "JUP", "KARS", "KAT7", "KCTD12", "KCTD5", "KDELC2", "KDELR1", "KDM1A", "KDM1B", "KDM2A", "KDM3B", "KDSR", "KHDRBS1", "KHDRBS3", "KHSRP", "KIAA0368", "KIF11", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF3A", "KIF4A", "KIF5B", "KIFBP", "KIFC1", "KLC1", "KLC2", "KNOP1", "KPNA1", "KPNA2", "KPNA3", "KPNA6", "KPNB1", "KRI1", "KTN1", "KYAT3", "L2HGDH", "LAMP1", "LAMP2", "LAMTOR1", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LAS1L", "LASP1", "LBR", "LDHA", "LDHB", "LDLR", "LEMD2", "LEMD3", "LETM1", "LGALS3", "LGALS3BP", "LGMN", "LIG1", "LIG3", "LIMA1", "LIPA", "LLGL1", "LMAN1", "LMAN2", "LMNB1", "LMNB2", "LNPEP", "LNPK", "LONP1", "LPCAT1", "LRBA", "LRPAP1", "LRPPRC", "LRRC40", "LRRC47", "LRRC59", "LSM6", "LSM7", "LSM8", "LSS", "LTA4H", "LUC7L2", "LYAR", "LYPLA1", "LZIC", "LZTFL1", "M6PR", "MACF1", "MAD1L1", "MAD2L1", "MAGT1", "MAIP1", "MAK16", "MAP1B", "MAP1S", "MAP2K1", "MAP2K2", "MAP2K3", "MAP4", "MAPK1", "MAPK14", "MAPRE1", "MAPRE2", "MARC1", "MARCKS", "MARS", "MARS2", "MASTL", "MAT2A", "MAT2B", "MATR3", "MAU2", "MAVS", "MBNL1", "MBOAT7", "MCAT", "MCCC1", "MCCC2", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCMBP", "MCTS1", "MCU", "MDC1", "MDH1", "MDH2", "MDN1", "ME2", "MECP2", "MED1", "MED24", "MESD", "METAP1", "METTL13", "MFAP1", "MFN1", "MFN2", "MFSD5", "MGEA5", "MGME1", "MGST2", "MGST3", "MIA3", "MICU1", "MICU2", "MID1", "MIF", "MIGA1", "MINPP1", "MIPEP", "MKI67", "MLEC", "MMAB", "MMS19", "MOGS", "MORF4L1", "MOV10", "MPHOSPH10", "MPI", "MPP1", "MPP2", "MPRIP", "MPST", "MRC2", "MRE11", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL14", "MRPL15", "MRPL17", "MRPL19", "MRPL20", "MRPL21", "MRPL37", "MRPL39", "MRPL40", "MRPL43", "MRPL44", "MRPL45", "MRPL47", "MRPL49", "MRPL58", "MRPL9", "MRPS15", "MRPS17", "MRPS2", "MRPS22", "MRPS23", "MRPS25", "MRPS27", "MRPS30", "MRPS31", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRPS9", "MRTO4", "MSH2", "MSH3", "MSH6", "MSI1", "MSMO1", "MSN", "MTA1", "MTA2", "MTAP", "MTCH1", "MTDH", "MTHFD1", "MTHFD1L", "MTHFD2", "MTOR", "MTPAP", "MTPN", "MTR", "MUT", "MYBBP1A", "MYCBP", "MYEF2", "MYG1", "MYH10", "MYH14", "MYH9", "MYL6", "MYO1B", "MYO1D", "MYO6", "NAA10", "NAA15", "NAA25", "NAA40", "NAA50", "NADK2", "NAE1", "NAF1", "NAGK", "NAGLU", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NAPG", "NARS", "NASP", "NAT10", "NAXE", "NBN", "NCAPD2", "NCAPG", "NCAPH", "NCBP1", "NCBP2", "NCKAP1", "NCL", "NCLN", "NCOA5", "NCSTN", "NDC1", "NDUFA10", "NDUFA13", "NDUFA2", "NDUFA4", "NDUFA5", "NDUFA7", "NDUFA8", "NDUFA9", "NDUFAF4", "NDUFAF7", "NDUFB10", "NDUFB3", "NDUFB4", "NDUFB5", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS7", "NDUFS8", "NDUFV1", "NDUFV2", "NEFL", "NEFM", "NEK9", "NELFA", "NELFCD", "NELFE", "NEMF", "NENF", "NES", "NFKB1", "NFS1", "NHP2", "NIFK", "NIP7", "NISCH", "NKRF", "NKTR", "NLN", "NMD3", "NME1", "NME2", "NMT1", "NNT", "NOC2L", "NOC3L", "NOC4L", "NOL10", "NOL11", "NOL6", "NOL7", "NOL8", "NOL9", "NOLC1", "NONO", "NOP10", "NOP14", "NOP16", "NOP2", "NOP56", "NOP58", "NOP9", "NOSIP", "NPC1", "NPEPPS", "NPLOC4", "NPM1", "NRBP1", "NRDC", "NSA2", "NSD2", "NSDHL", "NSF", "NSFL1C", "NSUN2", "NSUN5", "NT5C2", "NT5C3B", "NT5DC1", "NT5DC2", "NTMT1", "NTPCR", "NUBP2", "NUBPL", "NUCB1", "NUCB2", "NUCKS1", "NUDC", "NUDCD2", "NUDT1", "NUDT21", "NUDT5", "NUDT9", "NUFIP2", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP160", "NUP188", "NUP205", "NUP214", "NUP35", "NUP54", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NUTF2", "NVL", "NXF1", "NXN", "OAT", "OCLN", "OGDH", "OGT", "OLA1", "OPA1", "OSBP", "OSBPL11", "OSBPL6", "OSBPL8", "OSBPL9", "OSGEP", "OTUB1", "OXA1L", "P3H1", "P3H4", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PACSIN3", "PAF1", "PAFAH1B1", "PAFAH1B3", "PAICS", "PAK1", "PAK2", "PALLD", "PANK4", "PAPSS1", "PARK7", "PARN", "PARP1", "PARP2", "PASK", "PBK", "PBRM1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCID2", "PCK2", "PCLAF", "PCM1", "PCMT1", "PCNA", "PCYOX1", "PDAP1", "PDCD11", "PDCD4", "PDCD5", "PDCD6", "PDCD6IP", "PDCL3", "PDE12", "PDE4DIP", "PDE6D", "PDHA1", "PDHB", "PDIA3", "PDIA4", "PDIA6", "PDK3", "PDLIM1", "PDLIM5", "PDLIM7", "PDXK", "PEBP1", "PECR", "PEF1", "PELO", "PELP1", "PEPD", "PES1", "PEX14", "PEX19", "PEX5", "PFAS", "PFDN2", "PFDN4", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGP", "PGRMC1", "PGRMC2", "PHB", "PHB2", "PHF5A", "PHF6", "PHF8", "PHGDH", "PI4K2A", "PI4KB", "PICALM", "PIGK", "PIH1D1", "PIK3C3", "PIN1", "PIN4", "PINX1", "PIP4K2C", "PIR", "PISD", "PITPNA", "PITPNB", "PITRM1", "PKM", "PKMYT1", "PKN1", "PKN2", "PLA2G15", "PLAA", "PLBD2", "PLCG1", "PLD3", "PLD6", "PLEC", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLS3", "PM20D2", "PMPCA", "PMPCB", "PNN", "PNO1", "PNP", "PNPLA8", "PNPT1", "POFUT1", "POLA1", "POLD1", "POLDIP2", "POLDIP3", "POLE", "POLE3", "POLE4", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2A", "POLR2B", "POLR2C", "POLR2E", "POLR2G", "POLR2L", "POLR3A", "POLRMT", "PON2", "POP1", "POR", "PPA1", "PPA2", "PPAN", "PPAT", "PPIB", "PPID", "PPIE", "PPIF", "PPIH", "PPIL1", "PPIL4", "PPM1G", "PPME1", "PPOX", "PPP1CA", "PPP1CB", "PPP1R10", "PPP1R12A", "PPP1R7", "PPP1R8", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP4R3A", "PPP5C", "PPP6C", "PPT1", "PPT2", "PQBP1", "PRC1", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PREP", "PREPL", "PRIM1", "PRIM2", "PRKACA", "PRKAG1", "PRKAR1A", "PRKAR2A", "PRKCSH", "PRKDC", "PRKRA", "PRMT1", "PRMT3", "PRMT5", "PRMT9", "PRPF19", "PRPF3", "PRPF31", "PRPF38B", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPS2", "PRPSAP1", "PRPSAP2", "PRRC1", "PRRC2A", "PRRC2C", "PSAP", "PSAT1", "PSIP1", "PSMA1", "PSMA3", "PSMA4", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD6", "PSMD7", "PSME1", "PSME2", "PSME3", "PSME4", "PSMF1", "PSMG1", "PSMG3", "PSPC1", "PTBP1", "PTBP2", "PTCD1", "PTCD3", "PTDSS1", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK7", "PTPA", "PTPN1", "PTRH2", "PTRHD1", "PUF60", "PUM1", "PUM3", "PURA", "PUS7", "PWP1", "PWP2", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QDPR", "QKI", "QRSL1", "RAB10", "RAB11B", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB1B", "RAB24", "RAB34", "RAB3GAP1", "RAB3GAP2", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RAB8A", "RAB8B", "RAB9A", "RABEP1", "RABGAP1", "RAC1", "RACK1", "RAD21", "RAD23A", "RAD23B", "RAD50", "RAD9A", "RAE1", "RAI14", "RALA", "RALB", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP9", "RANGAP1", "RAP1GDS1", "RAPGEF2", "RARS", "RARS2", "RAVER1", "RBBP5", "RBBP6", "RBM10", "RBM12", "RBM12B", "RBM14", "RBM17", "RBM19", "RBM22", "RBM25", "RBM26", "RBM27", "RBM28", "RBM3", "RBM34", "RBM39", "RBM4", "RBM42", "RBM4B", "RBM5", "RBM8A", "RBMX", "RBMXL1", "RBPMS", "RCC1", "RCC2", "RCL1", "RCN1", "RCN2", "RDH11", "RDH13", "RDH14", "RDX", "RECQL", "REPS1", "RER1", "RETSAT", "REXO2", "REXO4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RFX1", "RHEB", "RHOA", "RHOG", "RHOT1", "RIC8A", "RIDA", "RIOX2", "RIPK1", "RMDN1", "RNASEH2A", "RNASET2", "RNF14", "RNF20", "RNF219", "RNF40", "RNH1", "RNPEP", "RNPS1", "ROCK2", "RP2", "RPA1", "RPA2", "RPAP1", "RPF2", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPN1", "RPN2", "RPP30", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RRBP1", "RRM1", "RRM2", "RRP1", "RRP12", "RRP1B", "RRP8", "RRS1", "RSF1", "RSL1D1", "RTCB", "RTN4", "RTN4IP1", "RTRAF", "RUFY1", "RUVBL1", "RUVBL2", "S100A10", "S100A11", "S100A13", "SACM1L", "SAE1", "SAFB", "SAFB2", "SAMHD1", "SAP18", "SAR1A", "SARNP", "SARS", "SARS2", "SART1", "SART3", "SBDS", "SC5D", "SCAF1", "SCAF4", "SCAMP1", "SCAMP3", "SCARB1", "SCARB2", "SCCPDH", "SCD", "SCFD1", "SCML2", "SCO1", "SCO2", "SCP2", "SCPEP1", "SCRIB", "SCRN1", "SDF4", "SDHA", "SDHB", "SEC11A", "SEC22B", "SEC23A", "SEC23B", "SEC23IP", "SEC24A", "SEC24B", "SEC24C", "SEC31A", "SEC61A1", "SEC61B", "SEC62", "SEC63", "SEH1L", "SENP3", "SEPHS1", "SEPT11", "SEPT2", "SEPT7", "SEPT9", "SERBP1", "SERPINB6", "SERPINH1", "SET", "SETD2", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFSWAP", "SFXN1", "SFXN4", "SGPL1", "SGTA", "SH3GL1", "SH3GLB1", "SH3GLB2", "SHCBP1", "SHMT1", "SHMT2", "SHOC2", "SHTN1", "SIGMAR1", "SIRT1", "SKIV2L", "SKIV2L2", "SKP1", "SKP2", "SLC16A1", "SLC19A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A17", "SLC25A20", "SLC25A22", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A33", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A4", "SLC29A1", "SLC2A1", "SLC33A1", "SLC35A4", "SLC35B2", "SLC35F2", "SLC3A2", "SLC7A1", "SLC9A3R1", "SLFN11", "SLIRP", "SLIT2", "SLK", "SLTM", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCC1", "SMARCC2", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC6", "SMCHD1", "SMN1*", "SMNDC1", "SMPD4", "SMYD3", "SMYD4", "SNAP23", "SNAP29", "SND1", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPC", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNU13", "SNW1", "SNX1", "SNX12", "SNX17", "SNX2", "SNX27", "SNX3", "SNX5", "SNX6", "SNX9", "SOAT1", "SOD2", "SON", "SORD", "SORT1", "SPAG9", "SPART", "SPATA5L1", "SPC24", "SPCS2", "SPEN", "SPOUT1", "SPPL2A", "SPR", "SPTAN1", "SPTBN1", "SPTBN2", "SPTLC1", "SPTLC2", "SQLE", "SQSTM1", "SREK1", "SRI", "SRM", "SRP14", "SRP54", "SRP68", "SRP72", "SRP9", "SRPK1", "SRPRA", "SRPRB", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF3", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSNA1", "SSRP1", "STAG1", "STAG2", "STAM", "STAMBP", "STARD3", "STARD3NL", "STARD7", "STAT1", "STAT3", "STAU1", "STAU2", "STIP1", "STK4", "STMN1", "STOM", "STOML2", "STRAP", "STRBP", "STRN", "STT3A", "STUB1", "STX12", "STX18", "STX5", "STX7", "STXBP3", "STXBP4", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGP2", "SUGT1", "SUN1", "SUPT16H", "SUPT5H", "SUPT6H", "SUPV3L1", "SURF4", "SURF6", "SUZ12", "SV2A", "SYNCRIP", "SYNE2", "TAF15", "TAGLN2", "TALDO1", "TAMM41", "TARDBP", "TARS", "TARS2", "TBC1D10B", "TBC1D13", "TBC1D15", "TBC1D4", "TBC1D9B", 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8.217921866043707 8.355116022963852 1.9487627742005753 0.3762024781602087 0.0055676834947117 0.0304079267332007 0.218711052695476 0.0009853705813108 9.575323853563669e-06 +Low set posteriorly rotated ears 17 62 3.066319731541483 0.0021671144125636 15.526699029126211 72.06067961165049 0.4681203282533587 0.6623308737141381 5.18275386713286 7.899164729363678 0.683290661035172 0.336090036713027 0.105960495145098 0.0877454489981553 0.357998285135033 0.0404714444021463 0.0208839244107541 +Schizophrenia 8 17 3.030687502043304 0.0024399763647333 5.444174757281553 19.50242718446602 0.9817145874838714 0.3473822480141803 2.400301366302062 2.641618717487706 1.084663392230114 0.3211478296747099 0.0008421159767842 0.1795501084992132 0.3302382631712943 5.002355224872171e-05 0.0001250677426663 +Hallucinations 14 39 3.0277106545522363 0.0024641390199622 11.20388349514563 45.44660194174757 0.6705549628539956 0.4221278622600144 3.902598644570227 4.462852401771342 1.2595119979903464 0.3693437289960082 0.0098417528706189 0.3837477700868037 0.624878431747349 0.000693686312984 9.272076262338654e-05 +Hydrocephalus 18 63 2.917881107680862 0.003524186945746 17.5 74.83009708737865 0.4864280032519437 0.6085787069163106 5.8879092832817435 9.478912056611868 0.8088784016382273 0.3500416531762792 0.1440700992514946 0.3946315037249025 0.5190346386600193 0.0815241480937562 0.0952776302481486 +Positional foot deformity 27 80 2.877213674252163 0.0040120382436321 22.300970873786408 96.55339805825244 0.470981590245106 0.6172073949948879 8.039447586992903 12.821385469067062 0.8290554661930905 0.3508533178081804 0.0045523099335742 0.1874708652463751 0.1846169452951574 0.0086937080794566 0.0005912519608492 +Hand polydactyly 12 26 2.8711331539345144 0.0040900320154975 9.114077669902912 32.17718446601942 0.810453590544338 0.4452800586149166 3.6615419153480793 5.309376559579211 0.948384387998628 0.3474317696921568 0.0508665528337804 0.5075688851536699 0.4159471493059022 0.0643860535211407 0.0258693004556998 +Abnormal circulating lipid concentration 23 67 2.853488617556331 0.0043242076965355 21.0995145631068 75.44417475728156 1.321442689138656 0.3287247628796158 8.33534407984455 6.5596064623065375 1.4065018349702674 0.365722219395451 3.1652590181898508e-06 0.0501087549876423 0.0002692057281971 9.403703328934904e-07 2.623415062419103e-07 +Abnormality of the cerebrospinal fluid 31 117 2.8100615828476347 0.0049532021338036 33.26456310679612 139.65776699029126 0.6333875809946081 0.5372237787257415 11.267291201647208 15.193792257662585 1.1555525507377646 0.3935007134599857 0.0397010389231635 0.3203772906736362 0.3750650396605051 0.0235133540697477 0.0064910416417979 +Toe walking 8 21 2.720187454391091 0.0065244917928659 6.740291262135922 22.805825242718445 1.1386089770349623 0.3130572717722256 3.272869930973316 2.572476621751866 1.068544148592376 0.2998505070337083 0.013750853814228 1.0 0.3927678686332497 0.0345596402774107 0.0007039256534767 +Duplication involving bones of the feet 8 17 2.709972496290275 0.0067288787648649 5.509708737864078 20.026699029126213 0.8286726631699953 0.4291828835649511 2.4019415513574103 3.6259268352065384 0.9263895151182656 0.3280751122544665 0.0400069192592499 0.3926779415133941 0.2642532592652132 0.0388423821354079 0.0635700451219669 +Polydactyly 13 39 2.6964474290695835 0.0070083459118215 11.310679611650484 46.383495145631066 0.4940210476850993 0.5724413826301078 4.278029503326489 7.043107173523872 0.8120189646080183 0.3348792109098461 0.1693819485428359 0.6294205244747506 0.5927685243744982 0.2258807256976847 0.1237409170430778 +Action tremor 11 50 2.677703646312477 0.007412877416852 13.143203883495143 54.47572815533981 1.1235280535029035 0.3645421720231636 5.4627047451961745 5.814853194507433 1.1817578847970691 0.3688885139588422 0.0100546074786141 0.1306031110532128 0.1345831656240081 0.0142393987273455 0.0046281983480623 +Abnormal muscle fiber morphology 20 61 2.667601905562764 0.0076394717580801 17.78640776699029 68.04126213592232 1.263675841483234 0.3649599499596623 6.500784844979595 6.6307423444197315 1.1691802531751734 0.3853191125649093 0.0092723558107422 0.0419630621111095 0.0201087197693027 0.0057603049551775 3.4641118751202166e-05 +Optic disc pallor 16 42 2.666347131258349 0.0076680470808661 14.480582524271844 48.592233009708735 1.02733963234224 0.3801436604957769 5.692535706296588 6.181615230530596 1.3595924408188145 0.3692839687174071 0.0703293836598904 0.114689393659792 0.1131806930644622 0.0090874501470917 0.0007721497372496 +Cognitive impairment 51 147 2.649016152429404 0.0080726473280672 40.38834951456311 166.01456310679612 0.9678903819313606 0.4602309002251459 12.35477425089026 15.27402711863426 1.6121748345734526 0.4202585511538368 0.0358079513894829 0.1691879352346343 0.4448352379341613 0.0131448306576223 0.0001595800844323 +Biliary tract abnormality 10 25 2.648816205507341 0.0080774246596169 8.184466019417476 26.4004854368932 1.3038634098573934 0.2674323053300255 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0.297036724651636 0.0036087885139134 0.1553991536419083 0.2897038292296705 0.001435579094649 0.0002207550796784 +Postaxial polydactyly 8 17 2.587986823858159 0.0096538673334805 5.650485436893204 19.983009708737864 0.6872746163829112 0.4733231406937239 2.5138789038041987 4.077192384198938 0.8522298312255787 0.3139153826677744 0.3301283090952763 0.4158765777114258 0.2930966068708724 0.2822143623883297 0.0917767700893373 +Clumsiness 8 19 2.587658961340837 0.0096630598467448 6.75 20.57766990291262 0.9027704056640264 0.2559090219975202 2.4698423753801175 2.2221930931993956 1.527926415027724 0.282470536898918 0.0119899180814745 1.0 1.0 0.0011113418092766 0.0005183300980067 +Dementia 19 52 2.5818464181273733 0.0098273307469378 17.021844660194176 58.19174757281554 0.9978727756866732 0.3214313161707923 5.814027938449679 5.568168011495494 1.793982160512653 0.3770196158976925 0.0035661306981377 0.1403881914917208 0.3851788136583873 0.0004857227802637 9.943246688150582e-06 +Abnormal heart valve morphology 17 62 2.5518819838790296 0.0107142804095596 17.83252427184466 77.13106796116504 0.4699099631595928 0.6096529829544438 6.02733340682127 8.717091003223958 0.8450929313560487 0.3556463006581863 0.1083978972082402 0.7229556725912962 0.7290528477683593 0.1063933122420944 0.0557755374920231 +Ventricular hypertrophy 9 33 2.5324387803645942 0.0113272147623293 10.04126213592233 36.45873786407767 1.1361758135608295 0.3518404639351837 4.440080726024568 4.153106961798495 1.0569836433105884 0.3376234863759063 0.0296939579535622 0.0761999214167486 0.0648492807338132 0.0805334871156173 0.0170591920619043 +Abnormal nipple morphology 10 39 2.524387683290973 0.011590003418566 13.361650485436892 56.58009708737864 0.0883301815844993 0.7265557731152416 5.0759078000239946 7.293825822996126 0.6077999844043368 0.2753528986060825 0.3965201090774061 0.5727294465065284 0.8213470059403644 0.2506280269831492 0.2343619597943695 +Limitation of joint mobility 22 86 2.479446607945049 0.0131586428961045 21.060679611650485 97.9368932038835 0.3085934150476662 0.6495028096480517 7.742751544501191 10.216391648179064 0.8329388631334591 0.334643383369233 0.0590313491567997 0.3739570139316887 0.4898022218778542 0.0314601425797926 0.0015295036250384 +Abnormal circulating cholesterol concentration 13 30 2.449953432997592 0.0142874691081973 9.691747572815531 31.70873786407767 0.976903841313624 0.2790879029908041 4.4525142732793395 3.04459115485426 1.5883623188049951 0.3063455707490317 6.268079278014567e-05 0.0502821167245636 0.0007862287659281 1.6820948400143537e-06 1.2846320479099324e-05 +Abnormal lower limb bone morphology 31 130 2.4418316815479435 0.0146129579711726 36.657766990291265 165.25728155339806 0.5352167715889311 0.634339097616788 11.388414435872194 20.95665476687095 0.8935720216867307 0.3771208726436903 0.0406731283288387 0.4909698367019133 0.6160029659646634 0.0237450467434521 0.081624091987714 +Enlarged thorax 7 13 2.441016827054132 0.0146459723157754 3.851941747572816 16.553398058252426 0.6878502324489157 0.4991384851328346 1.9804680030663864 2.795551790331099 0.7693523377829645 0.315559863824272 0.0146896731279065 1.0 1.0 0.0367529115341812 0.1079287008920704 +Amyotrophic lateral sclerosis 7 16 2.440324114295961 0.0146740896987462 4.453883495145631 16.203883495145632 1.0855969203541704 0.3037117925086244 2.3812188822255287 1.5445439412417563 1.0118111691913367 0.2917679915833991 0.0064128954450323 0.1795501084992132 0.0072464589525271 0.002945649466309 0.0006928140913565 +Aplasia hypoplasia of the optic nerve 9 20 2.4188544821101217 0.0155694672629911 5.771844660194175 22.26456310679612 0.3135236250229086 0.6167121693838472 2.716612592157657 2.947008776955784 0.7336251770407881 0.3022543069698225 0.3793251847464804 0.2939494471957771 0.5058832188962971 0.5239305988300642 0.0024397302644593 +Muscle stiffness 5 16 2.412908543155686 0.0158257901090141 5.109223300970874 19.216019417475728 1.2530133657268057 0.2695837776665858 2.5817154639007844 2.4582801786037667 1.0397164239726309 0.2961148999712332 0.0177456933272394 0.0285808600856777 0.0995728547031488 0.0438041643494559 0.0501645149458417 +Abnormality of the ureter 12 52 2.409955512964568 0.0159544658095149 14.45631067961165 67.05339805825243 0.1218966221247602 0.7331063101011022 6.967367347006928 9.043694531732992 0.6412381610032002 0.2901377665021091 0.1799340728062312 0.34423599812192 0.7090009099167462 0.1612980757999003 0.2527191322852705 +Optic nerve hypoplasia 8 15 2.4011361789687378 0.016344252790406 4.730582524271845 17.980582524271846 0.3906222275952121 0.5738959154398543 2.2732587811131824 2.3636839049274427 0.7542142933188677 0.299036883017174 0.2925965209483912 0.2480154974279715 0.4386006499544391 0.4204411777128519 0.0020586259473287 +Neuronal loss in central nervous system 4 12 2.3999480045915567 0.0163974008200022 4.087378640776699 12.526699029126211 0.982175765643533 0.2959736314179056 1.731247914675439 1.993135251988059 1.1236470294677874 0.2967990988512021 0.0020274514170642 1.0 1.0 0.0006954184772239 0.0139902560164694 +Bulbar signs 6 10 2.3981391877876064 0.0164786022143232 4.888349514563107 12.016990291262136 1.527818207801298 0.1656113111527082 2.218011046873564 1.4803576942139227 1.2783367300196684 0.2344360472575242 0.0025859838572013 1.0 0.2685353106225043 0.0009447024772989 0.0007278251765531 +Disproportionate short limb short stature 5 15 2.396524101372125 0.0165514049402484 6.587378640776699 19.902912621359224 1.344701363676014 0.2682000023842777 2.8599402401133336 3.1206003999939886 0.9439707190715964 0.2973700803613334 0.0353659279653998 0.2801168002074996 0.1411421437582085 0.0059425292278447 0.1130329164300312 +Contractures of the joints of the upper limbs 21 59 2.39360264825858 0.0166838121981651 15.5873786407767 70.82038834951456 0.961917368584866 0.453560490665382 5.296970733704175 9.19591360516456 0.9682537043334576 0.378553967263451 0.0199315023312676 0.0895964033786971 0.0637353710047468 0.018698697601217 0.0419753405307883 +Confusion 10 16 2.3901719741792182 0.0168404851546866 4.924757281553398 17.62378640776699 0.5770193034786405 0.489615172337713 2.480343831732211 2.1535063377225914 0.8853427180085949 0.3168581188371634 0.5799107476266856 1.0 1.0 0.6850187335780784 0.0072430636656091 +Disproportionate short stature 5 19 2.3892106013788057 0.0168846204083867 8.58252427184466 24.70145631067961 1.4449047806081987 0.2464238748623315 3.3320283680556178 3.793287097673045 1.0910515137563812 0.2952991105687103 0.0794528556341813 0.3498897642406863 0.2139520870514039 0.0207913960921613 0.1428107545701342 +Abnormality of visual evoked potentials 5 18 2.362530826205732 0.0181506318558615 5.912621359223301 21.344660194174757 0.5310511795384435 0.4083718861321034 3.290488782756552 2.4160960308239137 1.1796429833196167 0.3304773196682204 0.0432728676833208 1.0 1.0 0.0198035379531722 0.0171255123594616 +Motor neuron atrophy 8 22 2.36071603677904 0.0182396910615494 5.410194174757281 22.424757281553397 0.8356342611289532 0.3959768073616548 2.754377444710008 1.6813276911909307 0.954775311801755 0.3176984078794489 0.0128511180209854 0.2145132052152406 0.0125141686162342 0.006984722202598 0.0006053327615549 +Abnormal biliary tract morphology 8 22 2.3577590594754056 0.0183856218198434 7.427184466019417 23.174757281553397 1.329418499193971 0.249884151345828 2.8924137189053876 2.044064029481889 1.3393824039546371 0.2984385007787948 0.0027039935077702 0.225839943305071 0.4045619729724357 0.0016834035897202 0.0002030463281523 +Kyphosis 29 122 2.3457904179687143 0.0189867804118448 29.929611650485437 145.9878640776699 0.3337202935488039 0.7323725070888106 9.39233300445956 15.462838267358809 0.6349532376126086 0.3192536742406162 0.0194110206139115 0.5413773680429788 0.4945609276621039 0.0043140225134793 0.0013589865513913 +Abnormal circulating bilirubin concentration 10 28 2.338619515691465 0.0193551338738324 6.611650485436893 26.725728155339805 0.4812850312626911 0.5974382444384296 3.1729530813550246 1.934615238303275 0.7143081068469757 0.3163768833940157 0.0022792224504973 0.0018472853800074 0.0132042256106822 0.0075944976014186 2.666796014614581e-05 +Osteopenia 12 59 2.3339825326557886 0.0195966365681634 14.580097087378642 70.14320388349515 0.5468518828167999 0.5898264625753131 5.569149766058337 5.306286565364834 0.7866919750372822 0.3524913522638017 0.0047396691068598 0.2053530305687867 0.0276099885864509 0.0011181675997352 0.04670294636798 +Abnormality of upper limb joint 28 92 2.3255634654492945 0.0200418505073067 22.174757281553397 112.72815533980582 0.5181453657197084 0.6203796408917344 7.717622231118391 13.742566693149987 0.824816154844266 0.3600833350084496 0.1963043440780408 0.240165627658012 0.2584599048220547 0.2374094704467512 0.0618377178755845 +Talipes equinovarus 21 63 2.323030944384046 0.0201774901427378 17.890776699029125 76.62135922330097 0.5495068800315274 0.5880189289841166 6.331475723212702 10.674910704116524 0.8250227780407152 0.350320151193932 0.0019478530787988 0.3354134477872257 0.220765267095583 0.007346791712894 0.0022773828253331 +Deep palmar crease 4 13 2.3063516599568104 0.021090990733652 3.866504854368932 11.75728155339806 0.5990239856383347 0.4998099821006278 1.9281120141985588 1.1231545330869228 0.7799394834925686 0.2989134885739745 0.0651952457446114 0.1049896535105009 0.0206800818926893 0.1060727287920157 0.0043704316922178 +Renal agenesis 8 41 2.294712106669897 0.0217496285238196 11.104368932038836 52.58495145631068 0.3515217416182281 0.6544780729142105 5.336381845754198 5.2951770277229695 0.7079887182546287 0.3091424091849951 0.0417326172674888 0.004358479786631 0.0461562677274315 0.0196856428380044 0.1406995280461621 +Increased intracranial pressure 4 16 2.2939806026341145 0.0217916129558006 4.483009708737864 18.225728155339805 0.6089364319190148 0.5193135356051898 2.352895895910637 2.1988563231789326 0.7556358037224847 0.3144749703857186 0.285817926798242 1.0 1.0 0.4120011086653588 0.1513315101249232 +Knee flexion contracture 7 24 2.29302462634952 0.021846587200319 6.37621359223301 26.20631067961165 0.4874196163722039 0.571576100604669 2.548884628142718 2.167424085317431 0.796597726565237 0.3234136220769761 0.1036879696952727 0.0032330061916283 0.0222198796395938 0.0629955787418294 0.0100404750036471 +Metatarsus adductus 6 12 2.285369113800337 0.022291193472639 3.7694174757281553 13.25 0.9957104022100554 0.3572272245833284 1.816252583500775 2.104808410901558 0.7948300017734555 0.2882447196496276 0.0218176291796623 0.1471951297158956 0.2756599666896902 0.0010916803236277 0.0008855678200528 +Pathologic fracture 7 13 2.2778665309547947 0.0227345309089499 4.257281553398058 15.072815533980584 0.983166532607372 0.3143076297274698 2.133145812327421 2.2800397788540345 1.0713003315034937 0.2893419439464214 0.1586436486696043 0.1715759324473242 0.0548237001435711 0.0023536569339089 0.0004860179196387 +Abnormality of the larynx 12 42 2.262767903909258 0.0236500004268416 10.682038834951456 46.699029126213595 0.7426785971038559 0.4816723930500222 4.067795342682343 4.403407664230521 0.9382180075001202 0.3633154044529258 0.0056772401066899 0.5123592328378659 0.422683272943231 0.0098409249608595 0.028521676693297 +Abnormal bone structure 32 145 2.2489441339609884 0.0245160506179857 37.41747572815534 174.03398058252426 0.5052466892255619 0.6451089511590872 11.181012226303604 17.857684720378465 0.8786021869184294 0.373142151762858 0.0052820965613182 0.2265411639382284 0.0579797488047876 0.0028512781299665 0.0091439221604003 +Aplasia hypoplasia affecting the fundus 9 22 2.2422554418409013 0.0249448677729826 6.257281553398058 24.932038834951456 0.2486236198815205 0.6449173785148175 2.8072064662273517 3.5066154841715464 0.6897297472256995 0.2962245022839372 0.5086524508268317 0.3624074851394556 0.5981003184261293 0.6631309934563295 0.0148600283171556 +Hypopigmented skin patches 11 22 2.232875091583723 0.0255571825903506 6.461165048543689 25.37135922330097 0.4666867513080546 0.4923758628930654 3.0339417473242687 3.9530564673509807 1.0171256647501936 0.3356931601315818 0.0927056665492555 1.0 0.6020385613883348 0.1935096580394825 0.0873094135982188 +Unusual infection by anatomical site 2 10 2.2318702093607605 0.0256235423346589 3.907766990291262 13.49271844660194 0.7293808434681487 0.4605880442375236 1.9820157102817233 2.372464489866843 0.7897149485111757 0.3081613942392058 0.2113418752944266 1.0 1.0 0.3157753203157507 0.4036293153292029 +Cerebral inclusion bodies 6 12 2.2198974584314404 0.0264257290850224 3.844660194174758 13.655339805825244 0.5051551663301821 0.4226246963159299 1.8115448621120656 1.6612796655742368 1.090041660052819 0.3107400387490911 0.1211085530933606 1.0 1.0 0.007920049564759 0.0008855678200528 +Postural tremor 4 17 2.215758769539553 0.0267080275778808 5.194174757281553 17.851941747572816 1.214872214945056 0.2487017685351703 2.341305968762478 2.2981463861426747 1.2391489410765593 0.2821199379659175 0.0058694047651436 0.0157111699130222 0.0573531962335191 0.0155108289838298 0.0121842961258669 +Microdontia 6 23 2.214669441245465 0.0267827618374285 6.79126213592233 26.62135922330097 0.2926835447863038 0.6221511471419694 3.1882858040298023 3.2705407790552736 0.7151842473532629 0.2936653766443033 0.5028905058437084 0.3593003709489177 0.5941234999934473 0.183699096822524 0.2917142678000418 +Airway obstruction 4 14 2.2088130950256333 0.0271876438373332 4.116504854368932 15.12378640776699 0.9459797966632624 0.3434111484412289 1.9597947726604712 2.1010208413382245 1.0021021721123982 0.3085532788047633 0.0211705192410354 1.0 1.0 0.0515621560092188 0.1513315101249232 +Peripheral demyelination 6 14 2.194468672086937 0.0282017337392181 4.524271844660194 16.973300970873787 0.9472740181618832 0.3208012027704231 2.3341893675900383 2.269845761985369 1.1784704386991718 0.3026863353342601 0.0315839469192322 1.0 1.0 0.063688713570506 0.0021190704165708 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8.048543689320388 1.205673434171466 0.2055905154190861 1.747510449264718 1.0646904903887575 1.232151298114248 0.2464368010987078 0.001492984644032 0.0607401038440192 0.1191939669275513 8.796898694645245e-06 1.665940864684324e-05 +Photophobia 7 36 2.1821988193478066 0.0290948624097084 8.201456310679612 36.398058252427184 0.4678600054481162 0.5820727111270125 3.604298649244484 3.1999387306793547 0.8235485247156009 0.3378012969761652 0.0267666431074505 0.4544030019669794 0.7068750505758974 0.0830410243220573 0.2648527613241043 +Gastrointestinal obstruction 4 13 2.1723384518326587 0.0298301437228176 3.179611650485437 14.395631067961164 0.4370768856005501 0.5959720740817676 1.984594024332852 2.1791777953827336 0.7009394349443662 0.3010189105404992 0.2383153027439901 1.0 0.0876106046642714 0.3513790442708272 0.1013718771427775 +Abnormal aortic valve morphology 12 32 2.1524567002757107 0.0313614020820227 8.643203883495145 40.00970873786408 0.3771375227817258 0.6013013640738508 3.3791734249815333 4.169922691726094 0.7682658177529654 0.3210565311311592 0.4243273831324653 0.4675499462092397 0.7210047097516858 0.2075596517244451 0.0523560798520111 +Osteoarthritis 3 8 2.1504193826800613 0.0315220565294698 3.783980582524272 10.466019417475728 1.011181157871384 0.2141266987491498 1.7388858389175554 1.4384831140913243 1.3548711699904423 0.2434324139099127 0.091877172307066 0.1263420182810564 0.239336332644921 0.0294507732567689 0.0451666412494461 +Arthritis 6 33 2.127185720985436 0.0334046550689006 10.45631067961165 41.12864077669903 0.9299077951686036 0.3844403642845474 3.7326340917241647 4.351147052994631 1.200139433310656 0.3557501916131977 0.0474331518074178 0.4072806445693771 0.2822884275430105 0.0471384538848185 0.2738776042777909 +Abnormal rib cage morphology 23 61 2.124472558259907 0.0336306483461379 17.694174757281555 75.7135922330097 0.5488633555797945 0.5379800174608891 5.594611229067785 9.71314341791714 0.9782995531616954 0.3690468558866111 0.0918322871638002 1.0 0.9178927535771956 0.0878680723775271 0.040441002200951 +Abnormal joint morphology 51 225 2.1232509237573693 0.0337328307526623 52.30339805825243 266.1990291262136 0.2500788863693359 0.8078491493990106 14.864197165849184 27.339633008473005 0.6288365893380027 0.3047285664472046 0.0180109451643108 0.1484650201497488 0.1909535812957412 0.0143836604923143 0.0036997569455451 +Abnormality of femur morphology 11 52 2.1191774821053784 0.034075470554624 17.20873786407767 66.68203883495146 0.8363246416857221 0.4265359075043799 5.791282481104246 7.777760660479065 1.2398669594969238 0.3848538433547022 0.0094216468431377 0.6126651238553404 0.5680571559664561 0.0027901649450718 0.0537851876617483 +Abnormal circulating dicarboxylic acid concentration 10 41 2.111155431016016 0.0347589542544211 9.611650485436892 41.19660194174757 0.3636351001240374 0.5903090665886829 4.629439374954948 2.5633125009393525 0.8124485448597606 0.3243501761394795 0.0003854260225033 0.0004231087345942 0.0007394374554927 0.002033856678576 5.1052272328632354e-05 +Increased bone mineral density 7 22 2.11099101731367 0.0347730839605542 6.242718446601942 24.75 1.1480702818250033 0.3148175930983396 2.4533156459354677 2.2345749579547443 1.0849696139569316 0.312718333498069 0.0124527564664799 0.0514861271532366 0.0062902743773976 0.0101205340460747 0.011268941916556 +Thickened skin 32 93 2.109990753005352 0.0348591523714498 22.009708737864077 100.32766990291262 0.4385550996860712 0.6098739890089617 6.832596267878453 10.09935648280444 0.8592900670649001 0.3543867989618216 0.0013766014456169 0.3756902934555408 0.0161960353368202 0.0024617724575646 0.0016101707025298 +Feeding difficulties in infancy 27 129 2.092987910906081 0.0363502337345162 33.769417475728154 161.8495145631068 -0.0342419710849458 0.7873422822484195 10.6949192478914 16.593415314611576 0.5776887831696645 0.2850568811689649 0.0699238501433056 0.0646671204759486 0.1494145543962426 0.0825788112234662 0.021317413851273 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0.0375754458646331 21.16747572815534 100.42233009708738 0.6687590042181877 0.5853612155895958 7.458858708924721 11.434332835202127 0.8235264349573469 0.3682957054317731 0.0389568758705794 0.0494662102872503 0.061949520967179 0.0486575147202899 0.0140939116973917 +Myoclonus 19 77 2.076833206516941 0.0378169562375527 19.92718446601942 92.40291262135922 0.7794869182612147 0.4142145469430702 6.660238401732631 11.33633180094438 1.369340457412049 0.3858779422292388 0.1873318225178759 0.7132013601496378 0.7151414861748107 0.0219601648980681 0.0252052079333523 +Abnormality of the knee 15 69 2.074243320270281 0.0380567188367908 18.313106796116504 87.3131067961165 0.3621304338986751 0.6629253310601161 6.232667076902729 10.461511662764035 0.6968901749422698 0.325188898669675 0.1032644211813322 0.1288043366290671 0.1085324882857664 0.0516258692687128 0.0844327185528338 +Posterior embryotoxon 7 14 2.0619059329585503 0.0392166925804831 5.400485436893204 18.211165048543688 0.5603270949007155 0.5260153972846668 2.4736082204804974 3.2255911781388433 0.9025074564453092 0.3301763927361542 0.2450909025423804 1.0 1.0 0.1312000588255236 0.0397377338982377 +Splenomegaly 21 79 2.061151762994016 0.0392885637992026 20.660194174757283 86.74029126213593 0.5649049994066069 0.3835571498509289 6.419862077062851 7.868335701486235 1.546158503499524 0.3590721878602594 0.0010643876611813 0.3052095683601886 0.186637380486808 0.0040878244038074 0.0001491657964926 +Unexplained fevers 2 6 2.057430279962036 0.0396448549707573 1.5388349514563109 5.621359223300971 0.7467355824508212 0.3321409792965325 1.0149114466807625 0.7710351742240161 1.1275544850735062 0.2907731941603199 0.0011640041080717 1.0 1.0 0.00262770885776 0.0182159139614431 +Functional motor deficit 31 122 2.05693811712607 0.039692178844372 29.844660194174757 142.42233009708738 0.5480906983959746 0.6328805215223481 10.059055989942786 15.366123577335584 0.9036149646030954 0.3745397139529565 0.1323931063379294 0.5295725416042785 0.4776342600774479 0.0614074077771514 0.0009504822191431 +Cutaneous photosensitivity 4 20 2.0412710540740373 0.0412238925457231 4.45873786407767 23.25728155339806 0.4951941865269984 0.5365203315345327 2.635778170171519 2.496953559053009 0.8423686703892482 0.3178790898940878 0.0926279935222335 0.0028071579475431 0.0195000915431133 0.0543044475705096 0.1591907444431843 +Limited elbow movement 8 30 2.0379195056365766 0.0415579835459669 8.830097087378642 35.36407766990291 0.3473075768463138 0.61493055701004 4.099522466897024 4.319010907287496 0.788513801550926 0.3172232758685046 0.2801410137828216 0.0846554635732882 0.2570393345333788 0.0983363279904071 0.0575038072852266 +Abnormal umbilicus morphology 7 42 2.0337415983116616 0.041977655639386 13.033980582524272 59.648058252427184 0.1764138644839039 0.7022862234128957 5.650312361810693 8.15504615456065 0.6414220611132295 0.2955306480350833 0.0394235906130031 0.6419596602177522 0.6112605252989075 0.1405495619932706 0.582709837236581 +Zonular cataract 5 9 2.0299546940624213 0.0423611447461413 3.04126213592233 10.71359223300971 0.6482844736848132 0.4757859716104625 1.6665604248665455 1.9447488940504751 0.8413866153147622 0.3111450918700563 0.3574850580104054 1.0 1.0 0.1139407547181512 0.0008256536450065 +Abnormal epiphyseal ossification 6 16 2.0296941135232984 0.0423876416286734 6.451456310679611 16.274271844660195 1.1227269321938518 0.3276999393402902 3.140724178369711 2.4155680760400804 1.043634905787503 0.3148370578580727 0.0082408695261902 1.0 0.3496381161424667 0.0006205149914719 0.0011303287485076 +Decreased activity of mitochondrial complex iv 3 17 2.025871424441966 0.0427779622334536 3.878640776699029 15.9247572815534 0.8034271187166634 0.3445303465767608 2.844656052218728 1.5238137800378977 1.1422119451186783 0.2970372577525856 0.0139964215949567 0.1263420182810564 0.239336332644921 0.0294507732567689 0.0451666412494461 +Abnormality of lower limb joint 30 140 2.0227792334587 0.0430959136323845 33.80582524271845 166.25242718446603 0.2412979108610408 0.7714482514929651 11.09824463722585 17.08912584844864 0.6310491383229854 0.3006235946777967 0.0317641550238491 0.2031524712473982 0.3315812064370276 0.0140653286498488 0.012639852634483 +Abnormality of the 5th toe 4 7 2.0153031439149247 0.0438728957202991 2.9223300970873787 8.259708737864077 1.1073405288994291 0.2882520454965396 1.560677724258624 2.165041741031587 0.9522253135241228 0.2721172964763348 0.285817926798242 0.2443632781182481 0.4330643878145832 0.1655021226103433 0.1513315101249232 +Postaxial foot polydactyly 4 7 2.0153031439149247 0.0438728957202991 2.9101941747572817 8.179611650485437 1.1164564935210708 0.2854713626620553 1.5514456024758956 2.174827712105029 0.9565986562813577 0.2724819159224514 0.2113418752944266 0.2030241760545403 0.3684815592825167 0.1048323445251165 0.0772454186514108 +Orthostatic hypotension due to autonomic dysfunction 3 8 2.014528810852619 0.0439540431499922 2.8689320388349513 9.026699029126211 0.6690910568198125 0.3153802844238013 1.4405048418053912 0.8105887688186777 1.185865447592776 0.2910194211316744 0.0260812181848141 1.0 1.0 0.0041946485896371 0.0037759888499611 +Xerostomia 5 14 2.012802306740043 0.0441354311592327 4.225728155339806 15.218446601941748 0.9400183964262208 0.3676147626670514 2.1144482637513415 1.4041718405623504 0.8665256443899695 0.3037909474394171 0.0044251090952562 0.1635258499471353 0.0498890213657128 0.0118572988629309 0.0083426651664859 +Abnormally lax or hyperextensible skin 13 37 2.006547332189702 0.0447978840952574 10.3373786407767 42.60679611650485 0.3474462280446399 0.5687204029624341 3.951804420390705 4.299554326326563 0.9473596696641492 0.3538650259671493 0.4047670662395732 0.4570575797650001 0.3466902378808005 0.1905631828654432 0.0198075817040652 +Abnormality of the optic nerve 47 204 2.006305831047913 0.0448236282870955 55.26699029126213 243.98300970873785 0.3330545875114519 0.7420961441999799 15.8565039079985 26.975306987282984 0.8419720138567378 0.3446258953426701 0.41128510768446 0.6146115728997059 0.7672690653178742 0.1637897130665049 0.002568811571346 +Adducted thumb 7 20 2.001748287708481 0.0453118101695337 5.446601941747573 25.25 0.5076313711213677 0.5755718168648709 3.0480875918784256 2.983469831087573 0.7118893318244507 0.306562677082328 0.1884082447734194 0.3274019772455256 0.1891654013018039 0.1374400519295191 0.1042683327750613 +Abnormality of the bladder 26 100 2.0005035650085072 0.0454459153482538 24.097087378640776 118.16504854368932 0.1540424095408869 0.7492982973684422 9.054864661656111 13.310406971069954 0.6301427336805837 0.2964233691133315 0.0603383058432549 0.8245925557763388 0.6753984750160961 0.0500682847981148 0.0081087768933737 +Unilateral renal agenesis 5 17 1.9996700013891031 0.0455359095453329 4.62621359223301 20.31553398058253 0.5855038682969245 0.5321289482967012 2.124999653457358 2.488312770336574 0.7217913002653688 0.3066786091165442 0.2722440258313804 0.2370066357192962 0.4218292238453741 0.0463117823544705 0.0539791573859534 +Global brain atrophy 3 17 1.9954321022385335 0.0459957725939581 4.944174757281553 20.466019417475728 0.5470181350831151 0.5081828354508747 2.583421763532785 2.0184370286085005 0.920761985531802 0.3339660659374047 0.0089185628538315 0.1952735388158895 0.3559802976275766 0.0230341265569123 0.0664883963333954 +Elbow flexion contracture 6 22 1.9941756795943075 0.0461328589896166 6.728155339805825 25.49757281553398 0.4005296068252059 0.5766090162654979 3.258876376606738 2.9283505301145505 0.8105730741101873 0.3220832838154132 0.1232030318778912 0.0410390344011431 0.1378217675082697 0.02289977346361 0.0438235854673598 +Laryngomalacia 4 12 1.9903359863044272 0.0465539363578275 3.6723300970873782 13.71116504854369 0.5978398108837641 0.454570785907933 2.014971007950381 1.945013939586594 0.9121070716381354 0.3097177989827632 0.0249744489977978 1.0 1.0 0.0600215848699845 0.1753897866922502 +Abnormal diaphysis morphology 13 52 1.9866601957851335 0.0469600656153508 14.83980582524272 66.9878640776699 0.4527821244506883 0.5906467269591996 5.107444401245179 8.468522429377211 0.7856437055190839 0.340884591252888 0.0151961878563027 0.6419596602177522 0.3366791745883095 0.0052611400148688 0.0528287384837593 +Corneal opacity 22 48 1.986106640008852 0.0470214841502392 15.480582524271844 53.95631067961165 0.9517965339960472 0.3644495779961974 5.277458167452316 6.791845051563607 1.5225460520633525 0.3686110256368129 0.1318094830661828 0.6010849010057636 0.844544833291945 0.088693101408856 0.0429404120115179 +Muscle abnormality related to mitochondrial dysfunction 9 28 1.9855373663862288 0.0470847170906747 11.12378640776699 35.58252427184466 0.9791864828781052 0.3365990386989574 4.6259837298613 4.333263242301439 1.4740065920951253 0.3430734831138388 0.0321777538091352 0.2731012734555347 0.0261522178742545 0.0051340314390508 0.0012458006436326 +Muscle fiber atrophy 5 18 1.9841940772721527 0.0472342085629695 5.444174757281553 20.281553398058257 0.7686173455615849 0.4552894087545087 2.6272082803045267 1.888480540541262 0.8113647632820095 0.320700919049039 0.0511830306183537 0.1991580424676108 0.0733374275738533 0.0247625444605767 0.0232948805615619 +Nephropathy 5 18 1.983888818123536 0.0472682357392975 4.953883495145631 20.679611650485437 0.6460031144846833 0.4125859609731191 2.359716427347698 2.5216098734814283 1.0719980152629416 0.3150102108345451 0.3330284508699649 0.0388410242837302 0.1312354716944213 0.4697159455465771 0.0960095135742494 +Delayed cranial suture closure 6 29 1.9832803617106205 0.0473361217550261 7.716019417475728 29.325242718446603 0.7058204487281402 0.4787858893421486 2.9402522313721624 1.8749870392614547 0.9549766649562498 0.3518038054905379 8.228897637207472e-05 0.2443632781182481 0.1088269092294783 0.000471503205235 0.0067400711985061 +Abnormality of bone mineral density 22 110 1.9779196903987075 0.0479377672579954 27.356796116504853 134.4368932038835 0.3643048003328085 0.6271112047303443 9.127541669014532 13.17298640894851 0.8979996901173003 0.3610272080787325 0.0040447833972096 0.2753365640204097 0.0311893573963303 0.0050832445546605 0.0777441533874993 +Abnormality of salivation 12 38 1.9732949533027055 0.0484619675739368 10.385922330097088 43.94417475728155 0.5139050783203964 0.5805038594229843 4.239675737942635 4.152352245817229 0.8281008243632367 0.3500544754516901 0.0249728302280929 0.4490556485893446 0.3360548671302722 0.0099842252567749 0.0068423727131123 +Bulbous nose 7 35 1.965516160138257 0.0493545271526685 9.54368932038835 43.228155339805824 0.3257229405514545 0.6869162241468331 4.302351353110773 5.2051490092867905 0.6463034234587018 0.3125944913856818 0.0296146029665284 0.462328834210194 0.1280193928374065 0.0125127895069986 0.0947072158741516 +Abnormality of the alveolar ridges 4 6 1.9651606929933436 0.0493956417786938 2.1092233009708736 6.368932038834951 1.3424122348723253 0.2105791674194365 1.182482323454481 1.3741037061958896 0.9200079991465796 0.2386077675723682 0.0975417220600345 0.0084566179175882 0.031964215627013 0.0322769586697076 0.012132108209414 +Abnormality of the ribs 19 50 1.963227710482248 0.0496197208738404 15.46359223300971 63.26456310679612 0.6596881680500318 0.4822792711086646 5.162987649103379 7.327989071924885 1.0464354559452582 0.3722680363619953 0.0797831666327492 1.0 0.8660967690044565 0.060090907600599 0.0215924606435013 +Limb ataxia 9 22 1.9607739032073748 0.0499054036058126 6.597087378640777 24.114077669902912 0.989869123864314 0.3154216467413447 2.5039369509835696 2.8496458430585005 1.1323309577692284 0.292147514752726 0.2925965209483912 0.2480154974279715 0.4386006499544391 0.0543044475705096 0.0005033193877358 diff --git a/msigdb_hp/metrics.json b/msigdb_hp/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..1a54d35997fec073f836839769791a18e31fd4eb --- /dev/null +++ b/msigdb_hp/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2734, + "annotations_size": 4488, + "title": "Average number of proteins per term", + "value": 20.14193404634581 +} \ No newline at end of file diff --git a/msigdb_hp/paths.json b/msigdb_hp/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..f3ee8bf5e935b68dd1942c39a11577f05b2f1f4c --- /dev/null +++ b/msigdb_hp/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/msigdb_hp/fragment/C166/C166_val_log2fc"} \ No newline at end of file diff --git a/msigdb_hp/result.tsv b/msigdb_hp/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..ce35b09c31e43654355db5aab547a51e4f12fadc --- /dev/null +++ b/msigdb_hp/result.tsv @@ -0,0 +1,1787 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Mental deterioration 0.4887991595863309 3.255110472115412 0.00113348266296 0.993841705611412 0.0177249832451739 85 P27544,P50897,Q9BQE5,P21912,O75306,O15118,Q9Y487,Q14108,P35637,O95470,P21964,O76024,P54802,Q10713,P05067,O75503,Q9NQZ5,P22626,P04062,O60313,Q9NZJ7,O96008,P43243,P07602,O43681,P31483 26 +Hyperesthesia 0.9564421669106884 3.231978924777835 0.0012293612271316 0.9959972249335336 0.0187665754672347 2 Q9NZJ7 1 +Elevated serum acid phosphatase 0.9564421669106884 3.231978924777835 0.0012293612271316 0.9959972249335336 0.0187665754672347 2 Q9NZJ7 1 +Bilateral tonic clonic seizure with focal onset 0.9564421669106884 3.231978924777835 0.0012293612271316 0.9959972249335336 0.0187665754672347 2 Q9NZJ7 1 +Hyporeflexia of upper limbs 0.9399707174231337 3.15894353998777 0.0015834216270593 0.9991847603339497 0.0213405293160435 2 Q9NR77 1 +Negativism 0.9388726207906328 3.1540518629583483 0.0016102046760988 0.9992772325192444 0.0215719360786018 2 Q9BQE5 1 +Social and occupational deterioration 0.9388726207906328 3.1540518629583483 0.0016102046760988 0.9992772325192444 0.0215719360786018 2 Q9BQE5 1 +Atlantoaxial dislocation 0.9267935578330906 3.100054807774148 0.0019348483626939 0.9998320780093376 0.0245994318747041 2 Q8NCH0 1 +Abnormality of the radioulnar joints 0.92679355783309 3.100054807774148 0.0019348483626939 0.9998320780093376 0.0245994318747041 2 P16435 1 +Radioulnar dislocation 0.92679355783309 3.100054807774148 0.0019348483626939 0.9998320780093376 0.0245994318747041 2 P16435 1 +Low set posteriorly rotated ears 0.5231816880682271 3.066319731541483 0.0021671144125636 0.999940916769502 0.0267934145553327 62 O95202,Q15392,P37268,Q9UBM7,Q8NCH0,Q96L58,P98175,P16435,Q13363,O43924,Q10713,P36507,P50542,P04062,O75381,Q96J02,Q9UM00 17 +Facial capillary hemangioma 0.9161786237188884 3.052315331275125 0.0022708340994908 0.9999629444564267 0.0278456378101495 2 P16435 1 +Schizophrenia 0.7397665091507238 3.0306875020433037 0.0024399763647333 0.9999826860031272 0.0297571030568569 17 Q9BUK6,Q9BQE5,P21964,Q9NZJ7,P07602,O43681,P04062,P16615 8 +Hallucinations 0.5782825142933974 3.0277106545522363 0.0024641390199622 0.9999844694867452 0.0298429109862744 39 P36551,P35637,P50897,Q9BQE5,P21964,Q9NZJ7,Q8N0X7,O76024,P05067,O43681,P04062,O60313,P07602,O75503 14 +Nephrogenic diabetes insipidus 0.9077598828696976 3.0142599697032137 0.0025760696247676 0.9999906142463372 0.0305050144484358 2 Q9H9C1 1 +Posterior polar cataract 0.9011713030746722 2.984357534892937 0.0028417450093609 0.9999971605706564 0.0321366476755544 2 P08670 1 +Inverted nipples 0.8975109809663274 2.9676993147232844 0.0030003768376101 0.9999986096191 0.0333309189286985 2 Q15067 1 +Lambdoidal craniosynostosis 0.8975109809663273 2.9676993147232844 0.0030003768376101 0.9999986096191 0.0333309189286985 2 P16435 1 +Agenesis of cerebellar vermis 0.886896046852129 2.9192046145341997 0.0035092579823254 0.9999998593862776 0.0369707742363304 2 O43924 1 +Hydrocephalus 0.506054467507008 2.917881107680862 0.003524186945746 0.9999998685299684 0.0370411030737901 63 P11166,Q15125,O95202,Q15392,Q9NX14,O75312,P21964,Q96L58,P48651,Q9UBM7,P16435,P23786,Q13363,Q8TAA9,P08236,Q10713,P04062,Q9Y5P6 18 +Cutaneous abscess 0.8825036603221081 2.8990565960143244 0.003742873262416 0.9999999509060626 0.0389745132290564 2 Q13546 1 +Osteopetrosis 0.8795754026354381 2.8855980422334837 0.0039067075911747 0.9999999765323244 0.0396180288076564 2 Q15392 1 +Humeroradial synostosis 0.8795754026354351 2.885598042233466 0.0039067075911749 0.9999999765323244 0.0396180288076564 2 P16435 1 +Elbow ankylosis 0.8795754026354351 2.885598042233466 0.0039067075911749 0.9999999765323244 0.0396180288076564 2 P16435 1 +Positional foot deformity 0.4624642973310035 2.877213674252163 0.0040120382436321 0.9999999854000098 0.040372259276729 80 Q8TB36,Q8NCH0,Q9H9C1,P98175,P07196,O75845,Q8TAA9,P08236,Q9NR77,P61978,Q9Y487,Q96A33,Q15392,P21964,P16435,Q13363,Q9UM00,Q15125,Q8TD16,O95202,Q8NBU5,Q96L58,Q9NWM8,Q6NUQ1,Q9NVI7,Q9UBM7,Q9H267 27 +Hand polydactyly 0.6394283832674508 2.8711331539345144 0.0040900320154975 0.9999999897265692 0.0408821017495609 26 Q15125,O95202,Q15067,Q9UBM7,Q14739,P21964,P98175,O75845,Q13363,O43924,Q10713,Q9UM00 12 +Increased c peptide level 0.8744509516837496 2.861994325338233 0.0042098444434641 0.9999999940129304 0.0416302704538402 2 Q16836 1 +Centrocecal scotoma 0.8733528550512515 2.8569278815968184 0.0042776301829356 0.9999999955890808 0.0421934159582756 2 O75306 1 +Abnormal circulating lipid concentration 0.4891597304294597 2.853488617556331 0.0043242076965355 0.999999996424374 0.0425593073290601 67 P37268,Q9H845,P23786,O95470,Q15392,O75431,Q8N511,Q15125,P28070,P40939,P31751,Q15800,Q9NVI7,Q9UBM7,Q14739,O75844,Q9NZJ7,O43772,P06737,P07602,Q16836,O75381,P50402 23 +Deposits immunoreactive to beta amyloid protein 0.8674963396778953 2.829856012566552 0.00465689569603 0.9999999992020414 0.0448501027548984 2 P05067 1 +Finger agnosia 0.8674963396778953 2.829856012566552 0.00465689569603 0.9999999992020414 0.0448501027548984 2 P05067 1 +Abnormality of the cerebrospinal fluid 0.4228320402800718 2.8100615828476347 0.0049532021338036 0.9999999997902718 0.0466940096776091 117 P13073,O75306,P23786,Q8TAA9,O96000,P08236,Q9NR77,Q9Y6M9,Q7KZN9,P11166,Q15392,Q9NX14,P21964,P16435,Q13363,Q10713,P36507,Q15125,O95202,Q86Y39,Q16625,Q96L58,P48651,P04062,O43676,O75312,Q9UBM7,Q9NZJ7,P07602,O43681,Q9Y5P6 31 +Poor gross motor coordination 0.8609077598828736 2.7992975071245216 0.0051213927012887 0.9999999999017856 0.0476380689410232 2 O75503 1 +Hypertrophic nerve changes 0.8587115666178673 2.7890871078379957 0.0052856846318813 0.9999999999531968 0.0484125563834361 2 Q9NR77 1 +Tongue nodules 0.8546852122986901 2.7703364915647253 0.0055998408088608 0.9999999999886604 0.0503649009021396 2 O43924 1 +Alveolar ridge overgrowth 0.8546852122986897 2.7703364915647253 0.0055998408088608 0.9999999999886604 0.0503649009021396 2 Q15392 1 +Peripheral hypermyelination 0.8543191800878529 2.768629862717049 0.0056292546747527 0.9999999999900702 0.0505281899605804 2 Q9NR77 1 +Ambiguous genitalia male 0.8539531478770206 2.766922895653583 0.0056588137213087 0.9999999999913104 0.0505733923605081 2 Q15392 1 +Decreased specific antibody response to protein vaccine 0.852855051244511 2.7617999644375923 0.0057483685375281 0.9999999999941998 0.0510864910820322 2 Q13546 1 +Abducens palsy 0.9563222915403152 2.7451592239856284 0.006048154529078 0.9999999999985014 0.052986357977914 3 Q9NZJ7 1 +Short middle phalanx of finger 0.849194729136163 2.7447015132433936 0.0060565957314326 0.9999999999985576 0.052986357977914 2 Q8IWS0 1 +Intracellular accumulation of autofluorescent lipopigment storage material 0.8469985358711611 2.7344261646738235 0.0062489108394339 0.9999999999993948 0.0541411425625084 2 O75503 1 +Toe walking 0.655286736884365 2.720187454391091 0.0065244917928659 0.9999999999998256 0.0562032997435363 21 Q8TD16,P35637,Q99720,Q9NZJ7,P40939,O43681,P07602,P50402 8 +Duplication involving bones of the feet 0.6860598460007773 2.709972496290275 0.0067288787648649 0.9999999999999308 0.0577422713130284 17 Q15125,O95202,Q9UBM7,Q14739,P21964,Q13363,O43924,Q10713 8 +Abnormality of lysosomal metabolism 0.9474298852126384 2.708058383667485 0.0067678115499485 0.999999999999942 0.0579655309850554 3 Q9NZJ7 1 +Slow pupillary light response 0.94617356279751 2.7028038666023555 0.0068757305029039 0.9999999999999644 0.058539374124916 3 P07602,Q9NZJ7 2 +Abnormal pupillary light reflex 0.94617356279751 2.7028038666023555 0.0068757305029039 0.9999999999999644 0.058539374124916 3 P07602,Q9NZJ7 2 +Anti thyroid peroxidase antibody positivity 0.8389458272327973 2.69664517229228 0.0070041859869445 0.99999999999998 0.0591230384440884 2 Q96J02 1 +Decreased circulating igg subclass level 0.8389458272327955 2.6966451722922695 0.0070041859869447 0.99999999999998 0.0591230384440884 2 P17812 1 +Polydactyly 0.5395887026508919 2.6964474290695835 0.0070083459118215 0.9999999999999803 0.0591230384440884 39 Q15125,O95202,Q15067,Q9UBM7,Q14739,P21964,P98175,O75845,Q13363,O43924,Q10713,P61978,Q9UM00 13 +Knee clonus 0.8360175695461239 2.682865738984095 0.0072994288215726 0.9999999999999948 0.0608918895004052 2 Q8N0X7 1 +Action tremor 0.5064550850188426 2.6777036463124775 0.007412877416852 0.9999999999999968 0.0613819074664796 50 P35637,Q14108,Q99720,Q5JRX3,Q9NZJ7,O75306,Q9H6K4,Q9NR77,P07602,O43681,Q15233 11 +Cortical cataract 0.8338213762811166 2.6725168214216426 0.0075284599885609 0.999999999999998 0.0622241775850124 2 Q9H6K4 1 +Abnormality of the foot musculature 0.8330893118594511 2.6690644478315844 0.0076062853730511 0.9999999999999988 0.0625219940554098 2 O14979 1 +Abnormal muscle fiber morphology 0.4869781104162414 2.667601905562764 0.0076394717580801 0.9999999999999988 0.0626462309225402 61 P23786,P07196,Q9H2D1,P46976,P61978,P35637,Q70HW3,P09651,P05067,Q99720,P22626,O60313,O43676,Q9BUK6,O14979,O96008,P43243,Q9Y5P6,P50402,P31483 20 +Optic disc pallor 0.5259188196999433 2.666347131258349 0.0076680470808661 0.999999999999999 0.0626462309225402 42 Q86Y39,Q9BUK6,Q9NX14,Q9H0B6,Q96L58,Q9H061,O75306,Q96S66,Q9H6K4,O96000,Q9Y6M9,Q10713,O14936,Q8WWV3,O60313,O43676 16 +Cognitive impairment 0.3986248106836259 2.649016152429404 0.0080726473280672 1.0 0.0634946971940076 147 Q13057,Q9Y619,Q9Y2R0,P27544,P50897,Q9BQE5,P21912,O75306,O15118,P07196,P40855,P06865,P01889,Q9Y487,P11166,Q14108,P35637,O95470,P21964,O76024,P57740,P54802,Q10713,P05067,P09651,Q5T440,O75503,O00429,Q9NQZ5,Q99720,P22626,P49770,O75352,Q5JTZ9,Q9NR50,P50542,P04062,O60313,Q13144,Q9NZJ7,O96008,P35270,O43819,Q8N0X7,Q9H6K4,P43243,P07602,O43681,O75381,Q9Y5P6,P31483 51 +Biliary tract abnormality 0.6143488270924389 2.648816205507341 0.0080774246596169 1.0 0.0634946971940076 25 O95202,Q14108,Q14739,Q9NZJ7,Q13363,P09601,Q10713,P07602,O43681,P04062 10 +Abnormality of the metacarpal bones 0.5733627041382542 2.6428902309014024 0.0082201680070022 1.0 0.0635318051655537 31 Q32P28,O95202,Q9UBM7,Q14739,Q96L58,P16435,P25054,Q13363,P08236,O43924,Q15233 11 +Posteriorly rotated ears 0.4307526654831223 2.6366854480783273 0.0083720424276683 1.0 0.0640097553924623 91 Q9HC07,Q9Y619,P37268,Q8NCH0,P98175,P23786,O43924,P40855,Q9UHX1,Q15392,P16435,Q13363,P42892,Q10713,P36507,Q9UM00,O95202,Q96L58,Q7LGA3,Q96J02,P50542,P04062,Q9UBM7,P78347,O75381 25 +Delusions 0.688430551746002 2.599126469450749 0.0093461332898361 1.0 0.0693313160409662 16 Q9BQE5,P21964,Q9NZJ7,P07602,O43681,P04062 6 +Erlenmeyer flask deformity of the femurs 0.9209080922738924 2.5964506046832097 0.0094192447848846 1.0 0.069754501073261 3 P07602,Q9NZJ7 2 +Postaxial polydactyly 0.6661661412205911 2.587986823858159 0.0096538673334805 1.0 0.0707468394652381 17 Q15125,Q9UBM7,Q14739,P98175,O43924,Q10713,P61978,Q9UM00 8 +Clumsiness 0.6513779428203202 2.587658961340837 0.0096630598467448 1.0 0.0707468394652381 19 Q15067,Q9NZJ7,Q9NR77,O75503,P07602,O43681,Q05086,P31483 8 +Axial dystonia 0.9179290905766662 2.583824794323749 0.009771141726486 1.0 0.0713055025503569 3 Q99720 1 +Dementia 0.4950893365921139 2.5818464181273733 0.0098273307469378 1.0 0.0715991240134044 52 P27544,P21912,O15118,Q9Y487,P35637,Q14108,O76024,P09651,P05067,Q9NQZ5,P22626,P04062,O60313,Q9NZJ7,O96008,P43243,P07602,O43681,P31483 19 +Abnormal heart valve morphology 0.4737339845956416 2.5518819838790296 0.0107142804095596 1.0 0.0754877401540092 62 O95202,P37268,Q9NX14,P21964,Q8NCH0,O60488,Q96L58,O75844,Q13363,P08236,P55795,P01889,P61978,P04062,Q9UHX1,Q15233,O75431 17 +Vegetative state 0.909556938850238 2.548243930550134 0.0108266738028266 1.0 0.0759220500423218 3 P07602,Q9NZJ7 2 +Progressive peripheral neuropathy 0.909556938850238 2.548243930550134 0.0108266738028266 1.0 0.0759220500423218 3 P07602,Q9NZJ7 2 +Ventricular hypertrophy 0.5456780168962809 2.5324387803645942 0.0113272147623293 1.0 0.0789387264803324 33 O75844,Q9H9C1,P21912,O43772,P23786,P40939,O75431,Q9H267,Q15233 9 +Abnormal nipple morphology 0.5200334945466707 2.5243876832909735 0.011590003418566 1.0 0.080520023750038 39 Q96A33,O95202,Q15067,Q9UBM7,Q7LGA3,P23786,Q13363,P61978,Q15233,Q9UM00 10 +Stiff skin 0.7950219619326595 2.487647315922114 0.0128591184189579 1.0 0.085283807778615 2 O75844 1 +Severe failure to thrive 0.7950219619326595 2.487647315922114 0.0128591184189579 1.0 0.085283807778615 2 O75844 1 +Patchy alopecia 0.7950219619326595 2.487647315922114 0.0128591184189579 1.0 0.085283807778615 2 O75844 1 +Aplasia hypoplasia of the colon 0.7950219619326595 2.487647315922114 0.0128591184189579 1.0 0.085283807778615 2 O75844 1 +Prominent umbilicus 0.7950219619326595 2.487647315922114 0.0128591184189579 1.0 0.085283807778615 2 O75844 1 +Sclerosis of hand bone 0.7950219619326604 2.487647315922114 0.0128591184189579 1.0 0.085283807778615 2 Q15125 1 +Abnormal shoulder physiology 0.7950219619326595 2.487647315922114 0.0128591184189579 1.0 0.085283807778615 2 O75844 1 +Abnormal sweat gland morphology 0.7950219619326595 2.487647315922114 0.0128591184189579 1.0 0.085283807778615 2 O75844 1 +Epidermal hyperkeratosis 0.7950219619326595 2.487647315922114 0.0128591184189579 1.0 0.085283807778615 2 O75844 1 +Peroneal muscle atrophy 0.7950219619326585 2.4876473159221018 0.0128591184189583 1.0 0.085283807778615 2 Q9NR77 1 +Carcinoid tumor 0.7950219619326554 2.4876473159220893 0.0128591184189588 1.0 0.085283807778615 2 P25054 1 +Congenital muscular dystrophy 0.7950219619326522 2.4876473159220773 0.0128591184189592 1.0 0.085283807778615 2 Q9Y5P6 1 +Limitation of joint mobility 0.4239288171856221 2.4794466079450492 0.0131586428961045 1.0 0.0865661632094774 86 P37268,P23786,P25054,Q8TAA9,P08236,P01889,P51648,P16435,O76024,P54802,O75431,Q8TD16,Q8NBU5,Q96L58,Q7LGA3,P48651,Q96J02,Q05086,Q9BT22,O14979,O75844,Q9H6K4 22 +Reduced forced expiratory volume in one second 0.78989751098097 2.4629408732762488 0.0137802638572182 1.0 0.0891150204484082 2 Q96J02 1 +Morning glory anomaly 0.7895314787701353 2.461173534523571 0.013848336583176 1.0 0.0892978945191009 2 O60313 1 +Temporal optic disc pallor 0.7895314787701353 2.461173534523571 0.013848336583176 1.0 0.0892978945191009 2 O60313 1 +Abnormal circulating cholesterol concentration 0.5559739846037439 2.449953432997592 0.0142874691081973 1.0 0.0915944507589495 30 Q15125,Q15800,Q9NVI7,Q15392,P37268,Q9UBM7,Q14739,Q9NZJ7,P06737,P07602,O75431,Q8N511,P50402 13 +Abnormal lower limb bone morphology 0.3930108396158123 2.4418316815479435 0.0146129579711726 1.0 0.0928937044966331 130 Q32P28,Q8IWS0,P13073,P98175,P25054,O75845,O43924,P08236,Q9Y487,Q96A33,Q15392,P21964,P16435,Q13363,Q10713,O14936,O75431,Q15125,O95202,Q96L58,Q7LGA3,Q6NUQ1,P40939,P04062,Q13555,Q9UBM7,Q14739,O75844,Q9NZJ7,Q8N0X7,P07602 31 +Enlarged thorax 0.720477562646333 2.4410168270541317 0.0146459723157754 1.0 0.0929718864967472 13 Q32P28,Q14739,O75844,Q92917,P02545,P08236,P04066 7 +Amyotrophic lateral sclerosis 0.6619679311415626 2.440324114295961 0.0146740896987462 1.0 0.0930188058869679 16 P35637,Q99720,P22626,Q15165,P43243,Q92804,P31483 7 +Decreased circulating aldosterone level 0.7822108345534444 2.425754155693387 0.0152766149067431 1.0 0.096701618760879 2 Q13423 1 +Cardiorespiratory arrest 0.8806932600922495 2.424470827622379 0.0153307149898382 1.0 0.096771095463283 3 O43772 1 +Diaphyseal thickening 0.8798974734529477 2.4210340272369533 0.01547642852097 1.0 0.0973238080242498 3 P08236,Q14739 2 +Aplasia hypoplasia of the optic nerve 0.6178648751674426 2.4188544821101217 0.0155694672629911 1.0 0.0977283483584674 20 O14936,Q9NVI7,P37268,O75312,P25054,P07196,Q9Y5P6,P61978,Q9UHX1 9 +Abnormal mitochondrial number 0.7803806734992704 2.4168777050621006 0.015654275634374 1.0 0.0981234483897635 2 P46976 1 +Muscle stiffness 0.6574490585366027 2.412908543155686 0.0158257901090141 1.0 0.0990601757451264 16 P11166,Q15392,Q9NZJ7,P23786,P07602 5 +Abnormality of the ureter 0.4779037212832646 2.4099555129645673 0.0159544658095149 1.0 0.0993115708087423 52 O14936,Q9UBM7,P21964,O75844,P21912,Q7LGA3,P16435,P23786,P35606,Q8TAA9,P61978,Q86XL3 12 +Decreased ldl cholesterol concentration 0.8762897774375251 2.4054369337703885 0.0161531397641521 1.0 0.1002701123949027 3 P37268 1 +Ketotic hypoglycemia 0.77781844802343 2.404436159227868 0.0161974350595333 1.0 0.1004061996508086 2 Q13423 1 +Optic nerve hypoplasia 0.6742122939780382 2.4011361789687378 0.016344252790406 1.0 0.1007596243452506 15 Q9NVI7,P37268,O75312,P61978,P07196,O14936,Q9Y5P6,Q9UHX1 8 +Neuronal loss in central nervous system 0.7493113652795397 2.3999480045915567 0.0163974008200022 1.0 0.1008151153155001 12 P07602,Q9NZJ7,P35637,O15118 4 +Bulbar signs 0.8148455842208582 2.3981391877876064 0.0164786022143232 1.0 0.1009114012934076 10 P35637,Q99720,Q9NZJ7,P07602,O43681,P04062 6 +Disproportionate short limb short stature 0.673427418765174 2.3965241013721252 0.0165514049402484 1.0 0.1010649052678026 15 Q15125,Q32P28,Q15392,Q14739,Q7LGA3 5 +Contractures of the joints of the upper limbs 0.4653057781513753 2.3936026482585797 0.0166838121981651 1.0 0.101596945923155 59 Q9Y619,P37268,P23786,P07196,Q9NR77,Q99567,P35637,Q15392,P16435,P02545,P42892,P57740,Q99720,Q96L58,Q7LGA3,P48651,Q92917,Q8IZA0,P50542,O75844,P50402 21 +Confusion 0.6537123219636991 2.3901719741792182 0.0168404851546866 1.0 0.1019974323538913 16 P36551,Q9Y619,P11166,P40939,O96008,P18074,P19447,P01889,Q16836,P05067 10 +Disproportionate short stature 0.6207451778285569 2.3892106013788057 0.0168846204083867 1.0 0.1021258584210423 19 Q15125,Q32P28,Q15392,Q14739,Q7LGA3 5 +Cutaneous melanoma 0.7712298682284038 2.3723658936082073 0.0176745780325928 1.0 0.1056238431561608 2 P11802 1 +Neurofibrillary tangles 0.867813987550348 2.36868818118003 0.0178512965639077 1.0 0.1063154996008421 3 P05067,O15118 2 +Ovotestis 0.7701317715959031 2.3670099754547387 0.0179324494647588 1.0 0.1063154996008421 2 Q9NX14 1 +Abnormality of visual evoked potentials 0.6235845284009678 2.362530826205732 0.0181506318558615 1.0 0.1073254753216159 18 Q15067,Q9NZJ7,P07602,O43681,O75503 5 +Motor neuron atrophy 0.5936309003761376 2.36071603677904 0.0182396910615494 1.0 0.1074274717640864 22 P35637,Q16637,P22626,Q99720,Q15165,P43243,Q92804,P31483 8 +Abnormal biliary tract morphology 0.593206741359555 2.3577590594754056 0.0183856218198434 1.0 0.1080034957165675 22 Q14108,Q14739,Q9NZJ7,P09601,Q10713,P07602,O43681,P04062 8 +Kyphosis 0.3890703569928561 2.3457904179687143 0.0189867804118448 1.0 0.1106658058290386 122 Q9HC07,Q32P28,P50402,Q8IWS0,Q8NCH0,P21912,P08236,Q9NR77,P01889,Q9Y487,P51648,Q14108,Q13363,Q15125,Q8TD16,O95202,Q8NBU5,Q96L58,Q7LGA3,P48651,Q9NWM8,P04062,Q9BT22,Q9UBM7,Q14739,O75844,Q9H0B6,Q8N0X7,Q15233 29 +Abnormal circulating bilirubin concentration 0.5544790709086095 2.338619515691465 0.0193551338738324 1.0 0.1119184391469495 28 P36551,P11166,Q14739,Q9H9C1,P55263,P23786,O75845,P41440,O14936,Q9H267 10 +Oromandibular dystonia 0.8601244965214208 2.3352206613572783 0.0195318963233301 1.0 0.1122610233275427 3 P35637,Q99720 2 +Osteopenia 0.459698893131523 2.3339825326557886 0.0195966365681634 1.0 0.1124676533477207 59 Q13126,Q32P28,Q14108,O75844,Q96L58,Q9NZJ7,Q9NWM8,P06737,P07602,O75431,P04062,Q9Y487 12 +Pancreatic islet cell hyperplasia 0.8580567087845347 2.326200137776946 0.0200078763292135 1.0 0.1134998189226283 3 P16930 1 +Fulminant hepatic failure 0.8579666207089596 2.3258069375731725 0.0200288523801144 1.0 0.1134998189226283 3 Q16836 1 +Abnormality of upper limb joint 0.4057179432242752 2.3255634654492945 0.0200418505073067 1.0 0.1134998189226283 92 Q9Y619,P50402,P37268,P23786,P25054,P07196,Q9NR77,Q99567,Q15392,P16435,P02545,Q13363,P42892,P57740,P36507,Q15125,O95202,Q96L58,Q7LGA3,P48651,Q92917,Q8IZA0,Q96J02,P50542,P78347,O75844,Q9H6K4,Q15233 28 +Talipes equinovarus 0.4504051952613445 2.323030944384046 0.0201774901427378 1.0 0.1139076424661728 63 Q8TB36,Q8NCH0,P98175,Q8TAA9,P08236,Q9NR77,P61978,Q9Y487,Q96A33,Q15392,P21964,P16435,Q13363,Q9UM00,Q8TD16,Q15125,O95202,Q8NBU5,Q96L58,Q9NWM8,Q6NUQ1 21 +Psoriasiform dermatitis 0.856808305066141 2.320749845057914 0.0203003488364292 1.0 0.1144572431883098 3 Q15800 1 +Cold induced muscle cramps 0.8552990906097173 2.314156629384643 0.0206591320274545 1.0 0.1160427841542125 3 P23786 1 +Generalized lipodystrophy 0.8546520955665603 2.311328708711942 0.0208147054429788 1.0 0.1166247166393119 3 O75431 1 +Abnormal b cell subset distribution 0.7584187408491986 2.309687203678274 0.0209054777663144 1.0 0.1169872621137397 2 P17812 1 +Deep palmar crease 0.6959596757383101 2.3063516599568104 0.021090990733652 1.0 0.1176661371652931 13 P61978,Q9Y487,P98175,O75431 4 +Dilatation of the ventricular cavity 0.7576866764275298 2.306092832485023 0.0211054457259489 1.0 0.1176661371652931 2 Q9Y5P6 1 +Branchial cyst 0.7576866764275291 2.306092832485015 0.0211054457259494 1.0 0.1176661371652931 2 Q9UHX1 1 +Flat nasal alae 0.7573206442166887 2.3042951317088667 0.0212060820595545 1.0 0.1179341961378944 2 P19447 1 +Abnormality of amino acid metabolism 0.7573206442166887 2.3042951317088667 0.0212060820595545 1.0 0.1179341961378944 2 P19447 1 +Renal agenesis 0.4886593590543584 2.2947121066698974 0.0217496285238196 1.0 0.1202122325306683 41 Q15392,Q9UBM7,Q7LGA3,O75306,P16435,Q8TAA9,O43924,Q86XL3 8 +Increased intracranial pressure 0.6380113497836319 2.2939806026341145 0.0217916129558006 1.0 0.1202961364644937 16 P07602,Q9NZJ7,P21912,P25054 4 +Knee flexion contracture 0.5704027867493179 2.29302462634952 0.021846587200319 1.0 0.1203778452199484 24 Q8TD16,P37268,P21912,Q7LGA3,P48651,P23786,Q86XL3 7 +Metatarsus adductus 0.7274631461652352 2.285369113800337 0.022291193472639 1.0 0.1223018047740882 12 O95202,Q15392,Q9UBM7,Q96L58,Q13363,P08236 6 +Pathologic fracture 0.6908221553698299 2.2778665309547947 0.0227345309089499 1.0 0.1242275194207597 13 Q13126,Q14108,P22626,Q96L58,O75845,O15269,P04062 7 +Abnormality of the larynx 0.4821861055643642 2.262767903909258 0.0236500004268416 1.0 0.1286560023220184 42 P35637,Q9UBM7,Q14739,P21964,Q15165,Q9NZJ7,P16435,P25054,P43243,Q92804,P07602,Q9UHX1 12 +Cholangitis 0.7478038067349986 2.25743457864546 0.0239809330850775 1.0 0.1293586871223989 2 Q96J02 1 +Pili torti 0.7478038067349927 2.2574345786454315 0.0239809330850793 1.0 0.1293586871223989 2 P02545 1 +Abnormal bone structure 0.3741022281455046 2.2489441339609884 0.0245160506179857 1.0 0.1316124822649763 145 Q9HC07,Q32P28,P21912,P25054,P35606,P08236,P61978,Q9Y487,Q86XL3,Q14108,Q15392,Q13363,P54802,O75431,P38435,Q15125,P53634,O95202,P22626,Q96L58,Q9NWM8,P04062,P16930,Q13126,Q9UBM7,Q14739,O75844,Q9NZJ7,P06737,P07602,P51809,O75381 32 +Aplasia hypoplasia affecting the fundus 0.5767477216520428 2.2422554418409013 0.0249448677729826 1.0 0.1330703099724163 22 O14936,Q9NVI7,P37268,O75312,P25054,P07196,Q9Y5P6,P61978,Q9UHX1 9 +Reduced brain n acetyl aspartate level by mrs 0.8388368576632055 2.2419360107110453 0.024965508243488 1.0 0.1330703099724163 3 Q9NZJ7 1 +Abnormal brain choline level by mrs 0.8388368576632055 2.2419360107110453 0.024965508243488 1.0 0.1330703099724163 3 Q9NZJ7 1 +Abnormal brain n acetyl aspartate level by mrs 0.8388368576632055 2.2419360107110453 0.024965508243488 1.0 0.1330703099724163 3 Q9NZJ7 1 +Hypopigmented skin patches 0.5754202821938833 2.232875091583723 0.0255571825903506 1.0 0.1355799473587397 22 Q15125,P53634,Q9NX14,P21964,P21912,Q9NZJ7,Q8IZA0,P19447,P53701,P07602,O95453 11 +Unusual infection by anatomical site 0.7803118539662826 2.2318702093607605 0.0256235423346589 1.0 0.1357714970459848 10 Q8TAA9,Q14739 2 +Cerebral inclusion bodies 0.7151057706306202 2.2198974584314404 0.0264257290850224 1.0 0.1388743233414297 12 P22626,O96008,O15118,P05067,P04062,P31483 6 +Segmental peripheral demyelination remyelination 0.833394361039912 2.217937835681801 0.0265590712871208 1.0 0.1394118268264309 3 Q9NR77,P07196 2 +Postural tremor 0.6071885320182233 2.215758769539553 0.0267080275778808 1.0 0.1400299389830947 17 P35637,Q14108,O75306,Q9NR77 4 +Microdontia 0.5664298834008541 2.214669441245465 0.0267827618374285 1.0 0.140257917300326 23 Q96A33,P78347,Q96L58,Q7LGA3,Q9Y487,Q9UM00 6 +Airway obstruction 0.6588529442218012 2.2088130950256333 0.0271876438373332 1.0 0.1420467352059974 14 P21964,P09601,O75844,P16435 4 +Mild short stature 0.8308328294219439 2.2066221737074327 0.0273404665139991 1.0 0.1426790857149164 3 Q14739 1 +Peripheral demyelination 0.6563845768361074 2.194468672086937 0.0282017337392181 1.0 0.1461540196554402 14 Q8TB36,Q9NZJ7,P07196,Q9NR77,P07602,O43681 6 +Supranuclear gaze palsy 0.6387434971392729 2.1902365201968146 0.0285070879345241 1.0 0.1474718519018414 15 P35637,Q99720,Q9NZJ7,O15118,P07602 5 +Abnormal upper limb bone morphology 0.4250118090451539 2.18964361148791 0.028550093536952 1.0 0.1474718519018414 69 Q32P28,P98175,P25054,P08236,O43924,Q9UHX1,P16435,Q13363,P36507,O75431,P53634,O95202,Q96L58,Q7LGA3,P48651,P50542,Q9UBM7,Q14739,O75844,Q15233 20 +Pain 0.367677769170516 2.1861604673519737 0.0288038673947572 1.0 0.1485882262846788 150 P36551,P21912,P23786,P25054,Q8TAA9,Q9NR77,Q01844,P01889,Q02978,Q13546,Q14108,P35637,Q70HW3,P21964,Q15165,P42892,O14936,P22626,P28070,Q92804,P40939,P04062,O60313,Q8N1F7,Q8NFH4,Q15800,Q9BUK6,Q14739,O75844,Q13423,Q9NZJ7,Q9H6K4,O15269,P43243,P07602,P50402 36 +Hypocholesterolemia 0.8512310559137174 2.1835724683461573 0.0289936784688857 1.0 0.1490534123348905 7 Q15800,P37268,Q9UBM7,Q9NZJ7,P07602 5 +Photophobia 0.4897131262910598 2.1821988193478066 0.0290948624097084 1.0 0.1492317057083105 36 Q9NZJ7,Q13432,P48449,P01889,Q8WWV3,P07602,P51648 7 +Gastrointestinal obstruction 0.6719333376648267 2.1723384518326587 0.0298301437228176 1.0 0.1515211228362244 13 P16930,P21912,P42892,P25054 4 +Motor regression 0.7306002928257666 2.172140464465004 0.0298450696495593 1.0 0.1515211228362244 2 P11766 1 +Abnormal aortic valve morphology 0.5062720539554303 2.1524567002757107 0.0313614020820227 1.0 0.1562792349720455 32 P37268,P78347,P21964,Q96L58,O60488,O75844,P02545,P36507,P01889,P61978,P04062,Q9UHX1 12 +Truncal titubation 0.7265739385065864 2.1520702147354003 0.0313918246326436 1.0 0.1562792349720455 2 Q6PJG6 1 +Osteoarthritis 0.8173100532342161 2.1504193826800613 0.0315220565294698 1.0 0.1562792349720455 8 O75844,P04062,Q14108 3 +Abnormal pupillary function 0.9096450000974818 2.1467578557578415 0.0318125641102235 1.0 0.1567006120907947 4 P07602,Q9NZJ7 2 +Lateral clavicle hook 0.7247437774524184 2.1429339633884643 0.0321184013244297 1.0 0.1568524321480313 2 Q9Y619 1 +Recurrent hand flapping 0.8158944128728716 2.1403670433860738 0.032325115740722 1.0 0.1575191307756358 3 P55795 1 +Arthritis 0.4976010554803186 2.127185720985436 0.0334046550689006 1.0 0.1600000981315114 33 Q14108,Q14739,P21964,O75844,P28070,P04062 6 +Abnormal rib cage morphology 0.4365023490578838 2.124472558259907 0.0336306483461379 1.0 0.1605684572100713 61 Q9Y619,Q32P28,P25054,Q8TAA9,P08236,Q9UHX1,O75718,P16435,P02545,Q13363,P54802,P00813,O75431,P04066,Q9UM00,O95202,P50570,P48651,Q96L58,Q92917,Q9UBM7,Q14739,O75844 23 +Abnormal joint morphology 0.3428786500287539 2.1232509237573693 0.0337328307526623 1.0 0.1607218497706546 225 P50402,Q8IWS0,P37268,Q8NCH0,P21912,P23786,P25054,P07196,Q8TAA9,P08236,Q9NR77,P01889,Q9Y487,Q86XL3,Q9UHX1,Q96A33,Q14108,Q15392,P21964,P16435,Q13363,P42892,P36507,O75431,P38435,Q15125,Q8TD16,O95202,O75298,Q8NBU5,Q96L58,Q7LGA3,P48651,Q92917,Q8IZA0,P28070,Q6NUQ1,Q96J02,P04062,Q05086,O75312,Q9UBM7,Q14739,O75844,Q9NZJ7,Q8N0X7,Q9H6K4,O15269,P07602,Q9Y5P6,Q15233 51 +Vacuolated lymphocytes 0.7207174231332368 2.122804824393163 0.033770210413039 1.0 0.1607218497706546 2 P04066 1 +Prominent sternum 0.7207174231332334 2.122804824393142 0.0337702104130408 1.0 0.1607218497706546 2 O95831 1 +Abnormality of femur morphology 0.4495014194168253 2.1191774821053784 0.034075470554624 1.0 0.1618314411102143 52 Q96A33,Q32P28,Q14739,O75844,Q96L58,Q7LGA3,Q9NZJ7,P16435,P07602,O75431,Q9Y487 11 +Abnormal circulating dicarboxylic acid concentration 0.4690899475641281 2.111155431016016 0.0347589542544211 1.0 0.1640109125316401 41 P36551,P37268,Q14739,Q9H9C1,P55263,P23786,P41440,O14936,Q96EY8,Q9H267 10 +Increased bone mineral density 0.5582952190360941 2.11099101731367 0.0347730839605542 1.0 0.1640109125316401 22 Q15125,Q13126,Q14108,Q15392,Q14739,P54802,P04062 7 +Thickened skin 0.3885828914814374 2.109990753005352 0.0348591523714498 1.0 0.1640109125316401 93 Q9H9C1,P21912,P40855,P16615,P51648,O95470,Q06136,P14324,P09493,P02545,P36507,O75431,P00813,P04066,O95453,Q15125,P53634,O75352,Q9NWM8,P28070,P50542,P04062,P31751,Q15800,Q14739,O75844,P42167,P48449,O15269,O75381,Q9H267,P50402 32 +Punctate cataract 0.9003762257633314 2.109518782317294 0.0348998265302398 1.0 0.1640109125316401 4 Q8WWV3,P08670 2 +Biliary tract neoplasm 0.8990574640895803 2.104208968770686 0.0353602225318139 1.0 0.1653090403362301 4 P07602,Q9NZJ7 2 +Neoplasm of the gallbladder 0.8990574640895803 2.104208968770686 0.0353602225318139 1.0 0.1653090403362301 4 P07602,Q9NZJ7 2 +Generalized clonic seizure 0.8983043251406878 2.101175284164403 0.0356255821806708 1.0 0.1663762880612389 4 P07602,Q9NZJ7 2 +Gastric ulcer 0.8059913652152912 2.0961983492570537 0.0360645993330575 1.0 0.1673815116926184 3 P04062 1 +Elevated circulating long chain fatty acid concentration 0.8055657268399853 2.094295587809016 0.0362336571439796 1.0 0.1678190436142214 3 P50542,P23786 2 +Brushfield spots 0.8055657268399853 2.094295587809016 0.0362336571439796 1.0 0.1678190436142214 3 P50542,O75381 2 +Feeding difficulties in infancy 0.3703128685233877 2.092987910906081 0.0363502337345162 1.0 0.1681135138184452 129 P37268,P21912,O75306,P23786,O43924,P61978,Q9Y487,P35637,P21964,Q99707,O76024,Q10713,O14936,Q96EY8,Q99720,Q96J02,P40939,O60313,Q05086,Q9UBM7,Q9NZJ7,Q01105,P07602,O43681,Q16836,O75381,Q15233 27 +Macrovesicular hepatic steatosis 0.8979098477663805 2.092742436662344 0.0363721528337144 1.0 0.1681135138184452 5 P23786 1 +Abnormality of the biliary system 0.3803974757287784 2.08874580445152 0.0367306112789296 1.0 0.1695956619545639 99 P36551,Q9H9C1,O15118,P11166,Q96A33,Q14108,P21964,P55263,Q13363,P09601,Q10713,O14936,O95202,Q6NUQ1,Q96J02,P04062,Q9UBM7,Q14739,Q9NZJ7,P06737,P07602,O43681,O75381,Q9H267 24 +Abnormal auditory evoked potentials 0.8030172981059727 2.0853202861858704 0.037040237205264 1.0 0.1708495216621018 8 P07602,Q15125,Q9NZJ7,O60313 4 +Limb joint contracture 0.3946311503154281 2.0794561317062588 0.0375754458646331 1.0 0.1729626677338189 84 Q8IWS0,P37268,P21912,P23786,P07196,Q9NR77,Q86XL3,P35637,Q15392,P16435,P42892,Q8TD16,Q99720,Q96L58,Q7LGA3,P48651,Q92917,Q8IZA0,O60313,O75844,Q9Y5P6,P50402 22 +Myoclonus 0.3995306308277587 2.0768332065169415 0.0378169562375527 1.0 0.1738960036825172 77 P27544,P50897,P13073,O75845,P11166,Q14108,Q10713,P05067,O14936,O75503,Q9NQZ5,Q8NBU5,Q9UBX3,P04062,Q05086,Q9NZJ7,O96008,Q01105,P07602 19 +Abnormality of the knee 0.4152259694116797 2.074243320270281 0.0380567188367908 1.0 0.1746406484044144 69 Q8TD16,Q15125,P37268,O75312,P21964,Q96L58,P21912,Q7LGA3,P48651,P23786,Q8N0X7,P08236,Q9NR77,O75431,Q86XL3 15 +Atlantoaxial abnormality 0.8888164785837815 2.062878730870681 0.0391241513689641 1.0 0.1782631384202145 4 Q8NCH0,Q9NWM8 2 +Posterior embryotoxon 0.6337581369990781 2.0619059329585503 0.0392166925804831 1.0 0.1785035662284058 14 Q9NX14,P78347,P21964,Q7LGA3,P40855,P50542,O75381 7 +Splenomegaly 0.3969634996792715 2.061151762994016 0.0392885637992026 1.0 0.1786495180656752 79 P36551,O15118,P08236,P01889,Q13546,P11166,Q96A33,Q14108,Q15392,P21964,P54802,Q10713,O14936,P28070,Q6NUQ1,Q96J02,P04062,P16930,Q14739,Q9NZJ7,P07602 21 +Unexplained fevers 0.8477387497051441 2.057430279962036 0.0396448549707573 1.0 0.1799050648217986 6 P07602,Q9NZJ7 2 +Functional motor deficit 0.3697374746579425 2.05693811712607 0.039692178844372 1.0 0.1799378774278199 122 Q13057,Q9Y2R0,Q9H845,P21912,P23786,P07196,Q9H2D1,P46976,Q9NR77,P61978,O14773,P35637,Q15067,Q9NX14,Q8TD16,O75298,Q99720,Q9NWM8,Q15120,P40939,P04062,Q05086,Q9BUK6,Q9H0B6,Q9NZJ7,Q8N0X7,P43243,P07602,O43681,Q9Y5P6,P31483 31 +Aortic valve calcification 0.7953130721347492 2.0483545963637284 0.0405252669723985 1.0 0.1831595147755536 3 O75844,P04062 2 +Mitral stenosis 0.7953130721347492 2.0483545963637284 0.0405252669723985 1.0 0.1831595147755536 3 O75844,P04062 2 +Female hypogonadism 0.7947871764785619 2.045992563507189 0.0407571023320529 1.0 0.1840220073101145 3 O75844 1 +Abnormal response to endocrine stimulation test 0.7941614863366375 2.0431816069171056 0.0410344638149455 1.0 0.184676219234211 3 P16435 1 +Noncompaction cardiomyopathy 0.7941268456397972 2.043025958898414 0.0410498684629792 1.0 0.184676219234211 3 Q15233 1 +Cutaneous photosensitivity 0.5623147115885295 2.0412710540740373 0.0412238925457231 1.0 0.1851980277729783 20 Q06136,Q14108,P37268,Q9UBM7 4 +Limited elbow movement 0.5049428245098253 2.0379195056365766 0.0415579835459669 1.0 0.1865122301542997 30 P37268,Q96L58,Q7LGA3,P48651,P16435,P23786,Q9H6K4,Q96J02 8 +Abnormal umbilicus morphology 0.458164634647085 2.0337415983116616 0.041977655639386 1.0 0.1875520881180309 42 Q14739,P21964,Q8NCH0,O75844,Q9NWM8,P08236,Q9Y487 7 +Zonular cataract 0.765242891579596 2.0299546940624213 0.0423611447461413 1.0 0.1880395028576825 9 P11166,O76024,Q9H6K4,P08670,Q8WWV3 5 +Abnormal epiphyseal ossification 0.5957387309983251 2.0296941135232984 0.0423876416286734 1.0 0.1880395028576825 16 Q15125,Q9UBM7,Q14739,Q96L58,P08236,O75381 6 +Decreased activity of mitochondrial complex iv 0.5780460298050903 2.025871424441966 0.0427779622334536 1.0 0.1885928236775441 17 Q9Y2R0,Q9H0R6,Q70HW3 3 +Anomalous trichromacy 0.7898205785426584 2.0236588312045947 0.0430052672692338 1.0 0.1890378447642716 3 Q9H6K4,O60313 2 +Tritanomaly 0.7898205785426584 2.0236588312045947 0.0430052672692338 1.0 0.1890378447642716 3 Q9H6K4,O60313 2 +Abnormality of lower limb joint 0.3620600226630321 2.0227792334587 0.0430959136323845 1.0 0.1892509397085535 140 P37268,P21912,P23786,P25054,P08236,Q9NR77,Q9Y487,Q86XL3,Q96A33,P21964,P16435,Q13363,O75431,Q15125,Q8TD16,O95202,Q8NBU5,Q96L58,Q7LGA3,P48651,Q6NUQ1,Q05086,O75312,Q9UBM7,O75844,Q9NZJ7,Q8N0X7,P07602,Q9Y5P6,Q15233 30 +Fibrosarcoma 0.7894324907174652 2.021911669302354 0.0431854780079179 1.0 0.1894588712605432 3 Q13126 1 +Abnormality of the 5th toe 0.8129893606388389 2.0153031439149247 0.0438728957202991 1.0 0.1913523381853281 7 Q10713,O43924,Q9UBM7,Q14739 4 +Postaxial foot polydactyly 0.8129893606388389 2.0153031439149247 0.0438728957202991 1.0 0.1913523381853281 7 Q10713,O43924,Q9UBM7,Q14739 4 +Orthostatic hypotension due to autonomic dysfunction 0.7875837141740802 2.014528810852619 0.0439540431499922 1.0 0.1915201414147237 8 P07602,P04062,Q9NZJ7 3 +Xerostomia 0.6254593955439324 2.012802306740043 0.0441354311592327 1.0 0.1916006160570476 14 P35637,Q14739,Q15165,P43243,Q92804 5 +Aplasia hypoplasia of the sternum 0.7870125508859411 2.01101060329792 0.0443243367467114 1.0 0.1922006022408124 3 P98175 1 +Abnormally lax or hyperextensible skin 0.4680141749827183 2.006547332189702 0.0447978840952574 1.0 0.1932453830475357 37 Q9NX14,P78347,Q8NCH0,Q96L58,P48651,Q9NWM8,P38435,O96000,P36507,P04062,Q9Y487,Q9UHX1,O95453 13 +Abnormality of the optic nerve 0.3425703781997334 2.006305831047913 0.0448236282870955 1.0 0.1932453830475357 204 P50897,P37268,O75306,P98175,P25054,P07196,P41440,O96000,Q9Y6M9,Q7KZN9,P01889,P61978,Q9UHX1,Q15067,Q9NX14,P21964,Q9H061,Q13363,O76024,Q10713,P36507,O14936,P38435,Q15125,O95202,Q86Y39,Q96L58,Q7LGA3,P49770,Q9P0J0,P04062,O60313,O43676,Q9NVI7,Q9BUK6,Q9UBM7,O75312,Q9H0B6,Q9NZJ7,Q9BSJ2,Q9H6K4,P51572,P07602,O43681,O75381,Q9Y5P6,Q8WWV3 47 +Adducted thumb 0.5566311419869052 2.001748287708481 0.0453118101695337 1.0 0.1951625758549593 20 Q8NBU5,P78347,Q8NCH0,Q96L58,Q92917,P42892,Q86XL3 7 +Abnormality of the bladder 0.3729925889606634 2.0005035650085072 0.0454459153482538 1.0 0.1955525101466569 100 Q8NCH0,P21912,P07196,Q8TAA9,P35606,Q9NR77,P01889,P61978,Q86XL3,Q9UHX1,P11166,P35637,P21964,O60488,P16435,O76024,P09651,O75298,Q99720,P22626,Q9NWM8,P04062,Q9NZJ7,Q8N0X7,P07602,O43681 26 +Unilateral renal agenesis 0.5740717552788651 1.9996700013891031 0.0455359095453329 1.0 0.1957520709190174 17 Q9UBM7,Q7LGA3,P16435,P35606,Q86XL3 5 +Global brain atrophy 0.5734299812871425 1.9954321022385335 0.0459957725939581 1.0 0.1969742627878666 17 P07602,Q9NZJ7,O75306 3 +Elbow flexion contracture 0.5420908263600316 1.9941756795943075 0.0461328589896166 1.0 0.1971850201384755 22 P37268,Q96L58,Q7LGA3,P48651,P16435,P23786 6 +Laryngomalacia 0.6724725552087782 1.9903359863044272 0.0465539363578275 1.0 0.1986994190483333 12 P21964,Q9NZJ7,P07602,P16435 4 +Abnormal diaphysis morphology 0.4368223249243363 1.9866601957851335 0.0469600656153508 1.0 0.2000307306789323 52 Q9HC07,Q13126,Q32P28,Q14739,Q96L58,Q7LGA3,P48651,P16435,Q8N0X7,P08236,Q9NR77,O75431,Q9Y487 13 +Corneal opacity 0.439740129192006 1.986106640008852 0.0470214841502392 1.0 0.2000307306789323 48 O75845,P08236,P40855,P18074,P51648,Q9NX14,Q06136,P02545,Q13363,P04066,O95202,P10619,Q16625,P50542,P04062,Q9NVI7,Q9UBM7,P78347,O75844,P19447,P53701,O75381 22 +Muscle abnormality related to mitochondrial dysfunction 0.5096207874412336 1.9855373663862288 0.0470847170906747 1.0 0.2001100476353676 28 Q9Y2R0,Q86Y39,Q9BUK6,O75306,Q9UBX3,O96000,Q9Y6M9,O60313,O43676 9 +Muscle fiber atrophy 0.5661898342631388 1.9841940772721527 0.0472342085629695 1.0 0.2001596498063187 18 P35637,Q99720,P22626,P23786,P61978 5 +Nephropathy 0.5661444723134835 1.9838888181235357 0.0472682357392975 1.0 0.2001596498063187 18 P36551,Q14108,Q9H9C1,O76024,Q9H267 5 +Delayed cranial suture closure 0.5039521558424496 1.9832803617106205 0.0473361217550261 1.0 0.2001596498063187 29 Q32P28,O75844,Q8NCH0,O75431,Q9Y487,O75381 6 +Abnormality of bone mineral density 0.3662702208016181 1.9779196903987075 0.0479377672579954 1.0 0.2016351447552799 110 Q9HC07,Q32P28,P61978,Q9Y487,Q14108,Q15392,Q13363,P54802,O75431,Q15125,O95202,Q96L58,Q9NWM8,P04062,P16930,Q13126,Q14739,O75844,Q9NZJ7,P06737,P07602,P51809 22 +Abnormality of salivation 0.4621163299669298 1.9732949533027055 0.0484619675739368 1.0 0.2034586627425898 38 P35637,Q14739,Q15165,O60488,Q8N0X7,Q9NR77,P55795,Q92804,P01889,P43243,Q05086,Q15233 12 +Bulbous nose 0.4677772228482726 1.965516160138257 0.0493545271526685 1.0 0.206190101565355 35 Q96A33,P21964,P16435,P23786,P38159,P42892,O75431 7 +Abnormality of the alveolar ridges 0.8262131979904839 1.9651606929933432 0.0493956417786938 1.0 0.206190101565355 6 P53634,O43924,Q15392,Q9UBM7 4 +Abnormality of the ribs 0.4354695608158918 1.963227710482248 0.0496197208738404 1.0 0.2063886073047229 50 Q9Y619,Q32P28,P25054,Q8TAA9,Q9UHX1,O75718,P16435,Q13363,P54802,P00813,O75431,Q9UM00,O95202,P50570,P48651,Q96L58,Q9UBM7,Q14739,O75844 19 +Limb ataxia 0.5374936250203418 1.9607739032073748 0.0499054036058126 1.0 0.2073846772063769 22 O14773,Q14108,Q9BUK6,P07196,P41440,Q9NR77,Q8IV08,Q10713,P04062 9 +Abnormal neuron morphology 0.5114304444289567 1.9590356186330704 0.0501086155914105 1.0 0.207664192445737 27 P35637,Q16637,P22626,Q99720,Q15165,P43243,Q92804,P31483 8 +Abnormal shape of the frontal region 0.3808293951824857 1.952808145220951 0.0508423330251603 1.0 0.2083245258427198 89 Q15125,O95202,Q15392,Q15067,Q14739,P13073,Q96L58,P48651,P55263,P16435,P25054,Q13363,O43924,Q96J02,O75431,Q9Y487,Q15233 17 +Avascular necrosis 0.5835679964440769 1.952173339460833 0.0509176283245409 1.0 0.2083245258427198 16 Q9Y619,Q8IWS0,Q14108,O75844,P02545,P01889,P04062 7 +Bifid tongue 0.7738895294926977 1.9517006555628296 0.0509737547377673 1.0 0.2083245258427198 3 Q9UBM7 1 +Abnormal metacarpal morphology 0.5243075407617884 1.95076274329635 0.0510852757016282 1.0 0.2083245258427198 24 Q32P28,Q14739,Q96L58,P16435,P08236,O43924 6 +Vascular skin abnormality 0.3735599881352706 1.9460095025549589 0.051653598158502 1.0 0.209414045650729 96 Q15125,Q13126,Q14108,Q9UBM7,Q14739,Q06136,O75844,Q8NCH0,P21964,Q9NWM8,O75306,Q96L58,P21912,P38435,P01889,P04062,Q9Y487,P51648 18 +Decerebrate rigidity 0.8576227005051975 1.935954806423988 0.0528732363430051 1.0 0.2137793555922585 4 P07602,Q9NZJ7 2 +Bilateral cryptorchidism 0.7192483496084106 1.9303275141234104 0.0535662699895833 1.0 0.216191924202563 10 P48449,O43924,P37268 3 +Abnormal large intestine physiology 0.5575219356013202 1.9256873909775525 0.0541434192412044 1.0 0.2183249465898703 18 P21964,Q9NZJ7,P07602,Q8TAA9 4 +Spastic diplegia 0.5266902003906865 1.9234655010264896 0.0544216151010135 1.0 0.2190531018595055 23 P07602,Q99720,Q9NZJ7,P51648 4 +Radioulnar synostosis 0.5946385778446935 1.920907681709607 0.0547433471589919 1.0 0.220150664918957 15 O95202,Q96L58,P16435,P25054,Q13363 5 +Ichthyosis 0.4737349061523738 1.919507502051367 0.0549201377805999 1.0 0.2202781495896323 33 Q15125,Q15800,P50402,O95470,Q9H9C1,P48449,P40855,P36507,P50542,P04062,O75381,Q9H267,P51648 13 +Craniofacial asymmetry 0.7667925163344138 1.9194904587486736 0.0549222926450085 1.0 0.2202781495896323 3 Q13363 1 +Preaxial foot polydactyly 0.7667925163344138 1.9194904587486736 0.0549222926450085 1.0 0.2202781495896323 3 Q13363 1 +Infectious encephalitis 0.7913142431206199 1.9186478252569903 0.0550289186720038 1.0 0.2203120312220815 7 Q14739 1 +Talipes calcaneovalgus 0.8147905651513029 1.915860275982092 0.0553828829714799 1.0 0.2210675555953428 6 Q9H267,Q9H9C1,Q9NR77,Q9UBM7 4 +Nodular goiter 0.6797218155197663 1.9156107412546564 0.0554146613290464 1.0 0.2210675555953428 2 Q9UNW1 1 +Abnormal pleura morphology 0.5500143200100066 1.9133356138094697 0.0557051012661939 1.0 0.2220288583327518 19 Q8NCH0,P08236,Q96L58,Q14739 4 +Abnormal enchondral ossification 0.5147571008818594 1.911271009142693 0.0559697626426316 1.0 0.2221988364650054 25 Q15125,Q9Y619,O95202,Q9UBM7,Q14739,Q96L58,Q13363,P08236,P50542,P38435,O75381 11 +Abnormality of skull ossification 0.6899306036622257 1.91068709224418 0.0560448045629202 1.0 0.2221988364650054 11 O75718,Q32P28,Q14739,O75844,P54802 5 +Decreased activity of mitochondrial complex i 0.48344571945594 1.906537064202282 0.056580561660168 1.0 0.223927302231776 31 Q86Y39,Q9H845,Q70HW3,Q9H0R6,O75306,Q9UBX3,O96000,Q9Y6M9,O43676 9 +Abnormal circulating acetylcarnitine concentration 0.8122242337466438 1.9047523759350165 0.0568122671525335 1.0 0.2244484638913472 6 P40939,Q16836,O43772,P23786 4 +Intestinal malrotation 0.5293428826344276 1.9012720458822805 0.0572663885892228 1.0 0.225646665485893 22 O95202,Q15392,Q9UBM7,Q14739,P21964,Q8NCH0,Q13363 7 +Shoulder girdle muscle weakness 0.7133065084825545 1.9004824505686424 0.0573698358693133 1.0 0.2258559854223492 10 Q8TD16,O14979,Q9NZJ7,P43243,P07602 5 +Flat face 0.5357993029140227 1.899987208437852 0.0574347983099479 1.0 0.2259135625022315 21 Q15125,Q96L58,P08236,P50542,Q9Y487,O75381,Q13555,Q9UM00 8 +Increased cerebral lipofuscin 0.8479296445584575 1.8888411240205336 0.0589131205074522 1.0 0.2313896931426091 5 P07602,Q9NZJ7,P50897,O75503 4 +Symptomatic seizures 0.7604215001723089 1.8887142431318515 0.0589301290690735 1.0 0.2313896931426091 8 P00367,P40939,P31751,Q16836 4 +Cardiovascular calcification 0.7352823193216742 1.8859029423578328 0.0593080349578083 1.0 0.2326699832960173 9 O75844,O75431 2 +High frequency sensorineural hearing impairment 0.843860387261735 1.8794772375250808 0.0601793587391059 1.0 0.2355008491527201 4 Q9NWM8 1 +Hypoglycemic seizures 0.782574547338637 1.8794208721865513 0.0601870485691109 1.0 0.2355008491527201 7 P00367,P40939,P31751,Q16836 4 +Abnormal activity of mitochondrial respiratory chain 0.427258671274468 1.877274599965833 0.0604804676182906 1.0 0.2364428037202859 50 Q9Y2R0,Q86Y39,Q9H845,P13073,Q9NX14,Q70HW3,P21912,Q9H0R6,O75306,Q9UBX3,O96000,Q9Y6M9,Q7KZN9,O43676 14 +Abnormality of the distal phalanges of the toes 0.8430530961600445 1.8761554317745308 0.0606339399276354 1.0 0.2368364859836621 4 O75844,O75431 2 +Enlarged kidney 0.8438973801989444 1.8722194174685995 0.0611762537873168 1.0 0.2373501830058397 5 P23786 1 +Lissencephaly 0.4360127840630746 1.8720716172945289 0.0611966960695995 1.0 0.2373501830058397 44 Q15392,Q9H9C1,Q9BSJ2,P23786,O14936,Q9Y487,Q86XL3,Q9H267 8 +Fatigable weakness of bulbar muscles 0.5865600665151391 1.870737269739483 0.0613815062536029 1.0 0.2373501830058397 15 P35637,Q15165,P43243,Q92804,Q9Y5P6 5 +Hypoketotic hypoglycemia 0.7563974867849055 1.8699452800189869 0.0614914170266978 1.0 0.2374986915798793 8 Q16836,P31751,O43772,P23786 4 +Right ventricular hypertrophy 0.8429162741627356 1.868171385701376 0.0617381858688268 1.0 0.2379480377306971 5 Q9H9C1,Q9H267 2 +Abnormal atrioventricular valve morphology 0.4999673187922442 1.8679659685729857 0.0617668146070102 1.0 0.2379480377306971 27 P21964,Q96L58,O75844,P55795,O75431,P04062 6 +Slender long bone 0.6813922611219569 1.865879200927128 0.0620582681720287 1.0 0.2384567701678639 11 Q96L58,Q32P28,Q9Y487,P37268 4 +Abnormality of central nervous system electrophysiology 0.3573627188507156 1.8627825543660608 0.0624928654812106 1.0 0.2397162224612594 120 Q8IWS0,P50897,P13073,Q9BQE5,P07196,P11166,Q96A33,Q14108,Q15067,P21964,P00367,Q13363,P36507,O14936,O75503,P49366,Q15125,Q9NQZ5,O95202,Q96N66,Q8NBU5,Q9UBX3,Q5JTZ9,O60313,Q05086,Q9NZJ7,Q9BSJ2,P48449,P07602,O75381,Q9Y5P6 31 +Progressive neurologic deterioration 0.5423414921221388 1.8602346013857112 0.0628523416138122 1.0 0.2408892477905972 19 P21912,Q9NZJ7,P54802,P07602,O43681,P04062 6 +Abnormality of the nasal tip 0.3805935619418563 1.8585184850049696 0.0630954208543399 1.0 0.2416145467527966 80 Q96A33,O14936,O75844,P21964,Q7LGA3,P16435,P23786,P38159,Q9BSJ2,P25054,P42892,O43924,O75431,Q9Y487 14 +Arm dystonia 0.7528204289974383 1.855807894759539 0.0634809448871869 1.0 0.2423344810398073 3 Q99720 1 +Agitation 0.4715536923535748 1.8544940284526632 0.0636685136900148 1.0 0.2423615686520665 32 P35637,Q15165,O96008,P48449,P42892,P43243,Q92804,P05067,P04062 9 +Clonic seizure 0.8389282797575246 1.8517020110652616 0.0640686250842597 1.0 0.2427322844744419 5 P07602,Q9NZJ7 2 +Abnormality of toe 0.3517229213633676 1.851174214535228 0.0641444940701176 1.0 0.2427322844744419 139 Q8IWS0,Q8TB36,P37268,P13073,P23786,P25054,P07196,O75845,O43924,Q9NR77,P61978,Q9UHX1,Q96A33,P21964,O60488,Q13363,Q10713,O14936,O75431,Q9UM00,Q15125,O95202,Q99720,Q96L58,Q7LGA3,Q96J02,P04062,Q9UBM7,Q14739,O75844,Q8N0X7,Q15233 32 +Porokeratosis 0.6669106881405611 1.8500599655913037 0.064304907245013 1.0 0.2431343081007738 2 P14324 1 +Mitral valve calcification 0.8363939357075585 1.8487178098105177 0.0644985706433325 1.0 0.2434563372979616 4 O75844,O75431 2 +Cardiac valve calcification 0.8363939357075585 1.8487178098105177 0.0644985706433325 1.0 0.2434563372979616 4 O75844,O75431 2 +Abnormality of fontanelles 0.4438300496110327 1.8452994386562096 0.0649939921051856 1.0 0.2451201987967001 40 Q9Y619,Q32P28,O75718,Q15125,Q9BT22,O75844,Q8NCH0,P48651,P98175,P16435,P40855,P50542,Q9Y487,O75381 14 +Decreased light and dark adapted electroretinogram amplitude 0.7503439765318347 1.8444841457879513 0.0651126142571212 1.0 0.2453613877296054 3 Q15067 1 +Muscle weakness 0.3203366711752837 1.8396294761065064 0.0658226538205937 1.0 0.2472067534283051 247 Q9HC07,P36551,P50402,Q8TB36,Q9H845,P13073,Q8NCH0,P21912,O75306,P23786,P07196,P41440,O96000,Q9Y6M9,Q9NR77,P46976,P01889,P61978,Q9UHX1,P35637,Q15067,Q16637,Q70HW3,Q9NX14,Q15165,O60488,Q10713,P36507,P09651,O14936,Q8TD16,O75298,Q86Y39,Q99720,P22626,P50570,P48651,Q9NWM8,Q9P0J0,Q15120,Q5JTZ9,Q92804,P40939,O60313,O43676,Q13126,Q9BUK6,O14979,Q14739,Q9NZJ7,O43772,Q8N0X7,O15269,P43243,P07602,O43681,O75381,Q9Y5P6,Q15233,P31483 60 +Bilateral talipes equinovarus 0.8337390127083377 1.837760636691928 0.0660976843539429 1.0 0.2480321131943945 4 Q15392 1 +Sloping forehead 0.4376945061684177 1.834471639287101 0.0665840139315203 1.0 0.2494438921682053 42 Q13057,Q16625,Q9H9C1,Q13409,P98175,P23786,O75845,Q92917,P35606,Q9BSJ2,P57740,Q96EK5,O14936,Q86XL3,Q9H267 15 +Conjugated hyperbilirubinemia 0.8346744651472858 1.8341086099501025 0.0666378736132893 1.0 0.2494438921682053 5 Q9H9C1,Q9H267 2 +Constipation 0.3815926163375998 1.8340899186253297 0.0666406476625842 1.0 0.2494438921682053 75 P36551,P37268,Q9UBM7,P21964,Q8NCH0,P21912,Q7LGA3,P16435,P25054,Q8N0X7,Q8TAA9,P42892,P55795,P61978,P04062,Q05086 16 +Hip dysplasia 0.4423061526915631 1.8306467637390849 0.0671532838417752 1.0 0.250406634909985 40 Q8TD16,Q96A33,O95202,Q15125,Q9NVI7,Q96L58,Q9H9C1,Q7LGA3,Q13363,P61978,Q9H267 11 +Dysplasia of the femoral head 0.7473051973928122 1.8305744185032744 0.0671640897244874 1.0 0.250406634909985 3 O75431 1 +Contractures of the large joints 0.7472865848094095 1.8304891715410296 0.0671768245168498 1.0 0.250406634909985 3 O75431 1 +Lactose intolerance 0.6621522693997115 1.825620774798156 0.0679074042825265 1.0 0.2522917470364064 2 Q14566 1 +Abnormality of corneal size 0.4521971680525224 1.8236810409939872 0.0682003067192174 1.0 0.2531703693596754 35 Q15125,O95202,Q8NCH0,Q96L58,Q9NWM8,O75845,Q13363,Q96EK5,Q9Y5P6 9 +Abnormality of the gallbladder 0.4574283218778204 1.8220447690527937 0.0684481929881095 1.0 0.2536709249633656 34 Q96A33,O95202,Q9UBM7,P78347,P21964,P53004,Q9NZJ7,O75845,Q13363,P40855,P07602,O43681,P04062 13 +Abnormal foot bone ossification 0.7452564114033522 1.8211872282887795 0.068578401227612 1.0 0.2537344309229372 3 Q15125 1 +Wide intermamillary distance 0.5631227683445128 1.8205376155418431 0.0686771733220303 1.0 0.2537890827755794 16 P61978,Q9UM00,Q9UBM7,P23786 4 +Respiratory arrest 0.7690335319470049 1.8183634861800817 0.0690085953323034 1.0 0.2544869152435314 7 O43772,P23786 2 +Polar cataract 0.8282051282051289 1.81488887541711 0.069540988474277 1.0 0.2560564235021177 4 Q7LGA3,P08670,P25054 3 +Renal hypoplasia aplasia 0.4053546382223172 1.8148412954856952 0.0695483021945368 1.0 0.2560564235021177 63 Q15392,Q9UBM7,P21964,Q7LGA3,O75306,P16435,P25054,Q8TAA9,O43924,Q86XL3 10 +Abnormal nervous system electrophysiology 0.3440662045129367 1.812705587278237 0.0698772422782982 1.0 0.2570566092991825 152 Q8IWS0,Q8TB36,P50897,P13073,Q9BQE5,P07196,Q9NR77,P11166,Q96A33,O14773,Q14108,Q15067,P21964,P00367,Q13363,P36507,O14936,O75503,P49366,Q15125,Q9NQZ5,O95202,Q96N66,Q99720,Q8NBU5,P50570,Q15120,Q9UBX3,Q5JTZ9,O60313,Q05086,Q9NZJ7,Q9BSJ2,P48449,O15269,P43243,P07602,O43681,O75381,Q9Y5P6 40 +Postnatal growth retardation 0.4200958609745582 1.8093136533785197 0.0704022890393956 1.0 0.258564217028484 52 P11166,Q15125,O14936,Q96L58,Q13363,O76024,P08236,P06737,O75431,Q9Y487,Q9UM00 11 +Capillary hemangioma 0.7893150012795415 1.805094306196094 0.0710599259128283 1.0 0.2592820711355885 6 Q7LGA3,P16435,Q9UBM7 3 +Synostosis of metacarpals metatarsals 0.7415551436462131 1.8042103345284028 0.0711983398491582 1.0 0.2595760757457532 3 P16435 1 +Abnormal social behavior 0.4127981699762761 1.803694232681856 0.0712792541738183 1.0 0.2596601402046238 58 P11166,Q15125,Q86Y39,Q15067,Q9NX14,P78347,Q9NZJ7,O96008,O75306,Q9P0J0,O96000,Q9Y6M9,Q15233,P05067,O43681,P07602,Q9UHX1,O43676 18 +Abnormality of the shoulder girdle musculature 0.4870813030841874 1.803211955677826 0.071354933557719 1.0 0.2597189491826405 28 Q8TD16,O14979,Q9Y487,Q9NZJ7,P07196,P43243,P07602,O60313,Q9Y5P6,P50402 10 +Neck muscle weakness 0.6073801420652161 1.8023102957406787 0.0714965995789953 1.0 0.2597189491826405 13 P35637,Q99720,Q9NZJ7,P07602,Q9Y5P6 5 +Abnormality of epiphysis morphology 0.431747708941765 1.801801523722555 0.0715766379322426 1.0 0.2597189491826405 43 Q9HC07,Q15125,O95202,Q9UBM7,Q14739,Q96L58,Q7LGA3,P16435,Q13363,P08236,P38435,O75381 12 +Increased adipose tissue 0.8250309271583303 1.801750009837018 0.0715847460202598 1.0 0.2597189491826405 4 O75431 1 +Absent brainstem auditory responses 0.7396558037348957 1.795489418917775 0.0725757571000116 1.0 0.2614065662091309 3 O60313,P07196 2 +Myositis 0.7404267678437881 1.7951340160696052 0.0726323502813695 1.0 0.2614065662091309 8 P28070,P22626 2 +Loss of subcutaneous adipose tissue in limbs 0.8211702805251753 1.7857505985018485 0.0741396487491607 1.0 0.2638689481254826 4 O75431 1 +Aortic valve stenosis 0.7607999395318684 1.781075173554515 0.0749001708770937 1.0 0.2644783374479912 7 O75844,Q15125 2 +Tremor by anatomical site 0.4931614819731157 1.777170166837124 0.0755402463320646 1.0 0.2664785228569704 26 P35637,Q99720,Q15120,P07196,Q9NR77,Q05086 6 +Elevated hepatic transaminase 0.3722077444660462 1.7741513220014016 0.0760381235307969 1.0 0.2670258985964138 83 Q9HC07,Q9H845,Q9H9C1,P23786,O75845,P01889,Q15067,P55263,Q10713,O75431,Q8N511,P28070,Q6NUQ1,P40939,P16930,Q14739,O43772,P06737,Q16836,Q9H267 20 +Redundant skin 0.5064156135104572 1.7714971777966384 0.0764780615775297 1.0 0.2681512034062138 23 Q9NX14,Q8NCH0,P48651,P38435,O96000,P36507,Q9Y487 7 +Calcific stippling 0.7339294998279029 1.7691601502929677 0.0768671522652755 1.0 0.269060230256632 3 Q15125 1 +Abnormal bleeding 0.3679972261526086 1.7672098630595148 0.0771930885169935 1.0 0.2696051216064336 88 Q8NCH0,P21912,P23786,P25054,P01889,Q9Y487,Q02978,Q14108,P21964,O76024,P05067,Q96L58,Q9NWM8,P04062,P16930,Q13126,Q14739,O75844,Q9H267 19 +Sporadic 0.523166241178348 1.765749792318509 0.0774378351467481 1.0 0.2702496144157121 20 O95202,P21912,Q13363,Q9BWD1,P04062,Q05086 6 +Central apnea 0.7336514463237822 1.763245626963279 0.0778590714145217 1.0 0.2715085567275631 8 P07602,P11166,Q9NZJ7,O76024 4 +Narrow nasal ridge 0.7562032305037616 1.760205473039695 0.0783729743605168 1.0 0.273088438610248 7 O75431 1 +Abnormal larynx physiology 0.5828548072397763 1.7567188880425677 0.0789657364451648 1.0 0.2745145043887681 14 Q15165,P35637,P43243,Q92804 4 +Cupped ear 0.7078963224140311 1.7524839517324302 0.0796906270092521 1.0 0.2757529175154383 9 Q15392 1 +Hallux valgus 0.5819302219952245 1.751089491504483 0.0799304960574582 1.0 0.2763225173469514 14 P78347,Q96L58,Q96J02,P04062,Q15233 5 +Contractures of the joints of the lower limbs 0.41844230039441 1.750097366877675 0.0801015140526701 1.0 0.2763225173469514 47 Q8TD16,P35637,P37268,Q99720,P21912,Q7LGA3,P48651,P23786,Q9Y5P6,O60313,Q86XL3,P50402 12 +Retrocollis 0.7296703366847642 1.7495416250294282 0.0801974401834657 1.0 0.2764409458858635 3 Q99720 1 +Abnormality of the phalanges of the toes 0.682555800625955 1.7446688457730548 0.0810425292859629 1.0 0.2784918108119041 10 O75844,O14936,O75431 3 +Abnormal renal pelvis morphology 0.4233429565052716 1.7444980763969542 0.0810722765419478 1.0 0.2784918108119041 44 Q15125,O75718,Q9UBM7,Q8NCH0,P98175,P23786,P25054,P16435,O76024,Q8N0X7,P40855,P36507,P50542,P61978,O75381 15 +Malrotation of small bowel 0.8111114617413335 1.7439676806694815 0.081164725610956 1.0 0.2784918108119041 4 Q13363,Q8NCH0 2 +Metaphyseal cupping 0.728350407884957 1.7434558047045765 0.0812540277720961 1.0 0.2785184260262429 3 Q14739 1 +Aplasia hypoplasia affecting bones of the axial skeleton 0.3312781629874016 1.7430413067451027 0.0813263997334405 1.0 0.2785184260262429 181 Q13057,Q9Y619,P37268,Q8NCH0,P98175,P25054,O75845,Q8TAA9,O43924,P40855,P08236,Q86XL3,Q99567,Q9UHX1,Q15392,Q9NX14,P21964,P16435,P02545,Q13363,P57740,P55795,O75431,O14936,P46783,Q9UM00,Q15125,Q8TD16,O95202,Q16625,Q96L58,Q7LGA3,P48651,Q92917,Q6NUQ1,P50542,P04062,Q9BT22,Q9NVI7,Q9BUK6,Q9UBM7,Q14739,O75844,P78347,O75381,Q9H267 46 +Abnormality of the temporomandibular joint 0.7280439842572929 1.742042571043956 0.0815009953797414 1.0 0.2785184260262429 3 O75844 1 +Abnormal ureter morphology 0.5306392579124268 1.7420121425044692 0.0815063195663932 1.0 0.2785184260262429 18 O75844,Q7LGA3,P23786,Q8TAA9,O14936 5 +Bruising susceptibility 0.4966207605050339 1.7392696709165998 0.0819873395102501 1.0 0.2790633079753865 24 Q13126,Q14108,Q8NCH0,Q96L58,Q9NWM8,P04062 6 +Abnormal testis morphology 0.3308480003944224 1.732154931025007 0.0832459810164816 1.0 0.2813161936754524 176 Q8IWS0,P37268,Q8NCH0,Q8TAA9,O43924,Q01844,P01889,P61978,Q9Y487,Q86XL3,O95470,Q06136,P21964,P16435,Q13363,O76024,Q15125,O95202,Q7LGA3,P48651,Q9UBX3,P38159,Q9NVI7,O75312,Q9UBM7,Q13423,P48449,P46977,P51809,O75381,Q9Y5P6,Q15233 32 +Enlarged ovaries 0.8082010520323204 1.7318526877085052 0.0832997944125595 1.0 0.2813161936754524 4 P16435 1 +Central scotoma 0.7262625123926012 1.7283698209620098 0.0839219425266961 1.0 0.2829608618076 8 Q9H6K4,Q9H061,O75306,Q8WWV3 4 +Cns demyelination 0.5945918281724224 1.727340891605781 0.0841064593697278 1.0 0.2829608618076 13 Q15067,Q9NZJ7,P49770,P40855,Q9NR50,P07602,P51648 7 +Upper airway obstruction 0.8064334026582054 1.7244891081046394 0.0846195835547476 1.0 0.2835613523261418 4 O75844 1 +Abnormal visual electrophysiology 0.4184949429679273 1.723211165913482 0.0848503452450195 1.0 0.2839734149587232 45 P50897,Q15067,Q9NZJ7,O43924,P40939,O43681,O60313,P07602,O75503 9 +Limb girdle muscle weakness 0.5113016663387402 1.7226031202547143 0.084960320363177 1.0 0.2841295959686576 21 Q8TD16,Q13126,O14979,Q9NZJ7,P43243,P07602,O60313,Q9Y5P6 8 +Abnormal circulating long chain fatty acid concentration 0.8058608058608064 1.7221029321609786 0.0850508740509221 1.0 0.2842206423980183 4 P50542,O75381,P23786 3 +Barrel shaped chest 0.8054791628331678 1.7205122766968353 0.085339364036014 1.0 0.2849725191916898 4 Q14739 1 +Abnormal tendon morphology 0.3298576687632078 1.7170768817689066 0.0859651255780982 1.0 0.2862102994024516 181 Q13057,Q8IWS0,Q8TB36,P50897,P37268,Q8NCH0,Q9H9C1,P21912,P23786,P41440,P08236,Q9NR77,Q86XL3,Q96A33,P35637,Q15392,P16435,P42892,O75431,Q8TD16,Q99720,Q8NBU5,Q96L58,Q7LGA3,P48651,P28070,Q96J02,P04062,O60313,Q9BT22,O75312,Q9H0B6,O75844,Q8N0X7,P48449,Q9Y5P6,Q9H267,P50402 38 +Deep plantar creases 0.8058559154879538 1.714228977812083 0.0864866809074254 1.0 0.2877333016401224 5 Q9Y487 1 +Abnormally large globe 0.8019835892439484 1.7059341926987606 0.0880203326750157 1.0 0.2917542489257538 4 O75431 1 +Abnormal mitral valve physiology 0.4494229621383313 1.7036142013729516 0.088453186580006 1.0 0.2929726209380567 33 P40939,Q9NX14,P78347,O75844,Q96L58,O75306,P09493,P02545,O43819,P01889,O75431,P04062 12 +Abnormal larynx morphology 0.4916253099814365 1.7006561075428883 0.0890075817083708 1.0 0.2938945318031822 24 Q14739,P21964,Q9NZJ7,P16435,P25054,P43243,P07602 7 +Hyperintensity of cerebral white matter on mri 0.5193831672910582 1.6996864571206296 0.0891899180739603 1.0 0.2938945318031822 19 Q9BUK6,Q9NZJ7,P07602,O43681,O75503 5 +Increased muscle lipid content 0.7198799954118205 1.6981628120425585 0.0894770371972997 1.0 0.2946243161712994 8 P23786 1 +Dysphagia 0.3473174550979762 1.6956298078940155 0.0899560090792925 1.0 0.2956601872512881 112 P21912,O75306,O15118,Q9NR77,P01889,Q14108,P35637,Q15067,O76024,P05067,Q99720,P04062,O60313,Q05086,Q14739,Q9NZJ7,Q8N0X7,Q01105,P07602,Q15233 20 +Thin clavicles 0.7178103174389246 1.6947596772219684 0.0901210196434407 1.0 0.2956601872512881 3 O75844 1 +Eeg with irregular generalized spike and wave complexes 0.7175390843912615 1.6935042907513604 0.0903595188371007 1.0 0.2957777329469628 3 Q9NQZ5 1 +Facial hemangioma 0.7989556561871087 1.6932936406162926 0.0903995880087538 1.0 0.2957777329469628 4 P16435 1 +Lipoma 0.7414363304329981 1.6929168160166692 0.0904713019973479 1.0 0.2957777329469628 7 P21912,Q9BUK6,Q8TAA9 3 +Abnormal thalamic size 0.7173950676782016 1.692837672457917 0.0904863697273128 1.0 0.2957777329469628 3 P11166 1 +Wide anterior fontanel 0.5125428365642728 1.6896911089664732 0.091087065122678 1.0 0.2968763603998396 20 Q15125,Q32P28,Q9Y487,O75381 4 +Cerebellar cortical atrophy 0.7161476676493529 1.6870624520332314 0.0915913439917308 1.0 0.2983033032183512 3 O75312 1 +Calcinosis 0.7989994482288958 1.685538635267228 0.0918846972553655 1.0 0.2990417123147791 5 Q14739 1 +Lagopthalmos 0.7155805684215395 1.6844361192286077 0.0920974153233544 1.0 0.2992999275678601 3 O75844 1 +Fasting hyperinsulinemia 0.7956043956043964 1.6792897457509903 0.0930955884851074 1.0 0.3006185859910785 4 P40939,P00367,Q16836 3 +Hypoplasia of the iris 0.7974959832883471 1.6792392660501596 0.093105422185469 1.0 0.3006185859910785 5 Q13363,Q7LGA3 2 +Thin ribs 0.6459699416193108 1.6779683561731455 0.0933532766540983 1.0 0.3009838402468342 11 Q9Y619,Q32P28,O75844,P50570,O75431 5 +Abnormal circulating free fatty acid concentration 0.7942510109193552 1.6736303771052332 0.0942032646039121 1.0 0.3035062825142554 4 O75431,Q16836 2 +Fatigable weakness of swallowing muscles 0.585321239775873 1.6726702344348203 0.0943922320263328 1.0 0.3036790948632127 13 Q15165,P35637,P43243,Q92804 4 +Large placenta 0.7119881513818679 1.6677879218099398 0.0953578343954433 1.0 0.3055502614078271 3 O75844 1 +Visual loss 0.4254732725880829 1.667518176440036 0.0954114132103796 1.0 0.3055502614078271 40 O14773,P50897,P40939,Q9NZJ7,O75306,P48449,Q10713,P01889,O60313,P07602,O75503 11 +Aplasia hypoplasia of the nipples 0.5844167160217487 1.667321891698211 0.0954504158854219 1.0 0.3055502614078271 13 Q13363,Q96A33 2 +Recurrent fever 0.5841499621698154 1.6657441329685705 0.0957643877204499 1.0 0.3061186410893015 13 P61978,P51572,P28070,Q9NR77 4 +Abnormality of skin pigmentation 0.3454186464367921 1.6644776913166222 0.0960170055998825 1.0 0.3063001741234628 104 P36551,Q15125,P53634,O75312,Q14739,Q06136,O75844,Q9NZJ7,P21964,Q7LGA3,P21912,P25054,Q05086,P07602,O75431,P04062,P16615,P51648 18 +Hypoplastic vertebral bodies 0.7573077984646379 1.66443303187373 0.0960259235721283 1.0 0.3063001741234628 6 Q8TAA9,Q14739 2 +Polyneuropathy 0.5675328808400334 1.6630547692967077 0.096301472686618 1.0 0.306960944188595 14 Q15041,Q9NZJ7,Q15120,P31930,P07602,O60313,P04066 7 +Abnormal metatarsal morphology 0.5086421793009875 1.661632026598752 0.0965865777554382 1.0 0.3076512143125668 20 Q15392,Q9UBM7,Q96L58,P16435,Q13363,P08236 6 +Decreased muscle mass 0.5382077573675785 1.6578154137197942 0.0973547292145393 1.0 0.3096584158149204 16 O95202,Q8NCH0,Q13363,Q8TAA9,Q9Y487 5 +Abnormality of long bone morphology 0.3417387713061519 1.6569798027996534 0.0975235585542428 1.0 0.3098268703573784 132 Q9HC07,Q32P28,P37268,P98175,P25054,P08236,Q9NR77,Q9Y487,Q9UHX1,O60488,P16435,Q13363,P36507,P09651,O14936,O75431,P38435,Q15125,O95202,P22626,Q96L58,Q7LGA3,P48651,Q6NUQ1,Q96J02,Q13126,O75312,Q9UBM7,Q14739,O75844,Q8N0X7,O75381 32 +Abnormality of the tonsils 0.7555967909752657 1.656870007461351 0.0975457593170623 1.0 0.3098268703573784 6 P21964,P31751,Q13546 3 +Abnormal peripheral myelination 0.4812897424341642 1.6502327780556767 0.098895335149074 1.0 0.3130058280317659 25 Q8TB36,Q9H0B6,Q9NZJ7,P07196,O15269,Q9NR77,P07602,O43681 8 +Duplication of hand bones 0.4087452994451724 1.64881776337847 0.0991849746832316 1.0 0.3137013152771977 47 Q15125,O95202,Q15067,Q9UBM7,Q14739,P21964,P98175,O75845,Q13363,O43924,Q10713,Q9UM00 12 +Impaired proprioception 0.4374311173413261 1.6402836386251047 0.1009462058991517 1.0 0.3183742600670364 34 O75298,O14773,Q9H0B6,Q15120,P07196,Q8N0X7,P41440,Q9H6K4,Q9NR77,Q8IV08,P54802 11 +Meningitis 0.7512264682479076 1.637533258680391 0.1015190955232578 1.0 0.3190600145016676 6 Q8TAA9 1 +Furrowed tongue 0.7869889480230718 1.6351356214205588 0.1020206202469582 1.0 0.3203154907363553 5 P21912 1 +Overlapping toe 0.4991102854357512 1.63322450217892 0.1024217885325915 1.0 0.3212222130917336 21 Q15125,Q96A33,Q9UBM7,P61978,Q9UM00 5 +Genetic anticipation 0.624084919472916 1.628467356413323 0.103425825508383 1.0 0.3236925417584542 2 Q9UBB4 1 +Loss of eyelashes 0.7033889800306836 1.6278613703071472 0.1035542840391214 1.0 0.3237819289098295 3 O75844 1 +Abnormal sternum morphology 0.3562543216508808 1.6271712608488986 0.103700729667393 1.0 0.3237819289098295 90 Q9Y619,Q8NCH0,P21912,P98175,P08236,P61978,Q9Y487,Q9UHX1,O75718,Q96A33,P02545,Q13363,P57740,P55795,P36507,O75431,O95202,Q96L58,Q7LGA3,Q96J02,P04062,Q9NVI7,Q9BUK6,Q14739,P78347,P50402 26 +Color vision defect 0.6364559329167152 1.6269723890314305 0.1037429620704846 1.0 0.3237819289098295 11 Q9H6K4,Q9H061,Q8WWV3,Q13432 4 +Biparietal narrowing 0.6812649552335909 1.6212559269868705 0.1049627628726492 1.0 0.3271339442864235 9 O75845,Q10713,O43924,Q9UBM7 4 +Incoordination 0.3902886492773519 1.6202222981054828 0.1051845331721903 1.0 0.3275976300324706 62 Q15067,O43681,Q99707,P21912,Q9NZJ7,Q9Y5P6,Q01105,Q9NR77,Q10713,P40939,Q05086,P04062,P07602,O75503,P31483 15 +Gastrointestinal hemorrhage 0.4730217327613515 1.6164376483285643 0.1059997240525612 1.0 0.3290796514117601 26 Q14739,P21964,P21912,P25054,O76024,P01889,P16930 7 +Abnormal elasticity of skin 0.4014450716679531 1.6163114153224418 0.106026999986944 1.0 0.3290796514117601 54 Q13126,Q9NX14,P78347,O75844,Q8NCH0,Q96L58,P48651,Q9NWM8,P02545,P38435,O96000,P36507,P04062,Q9Y487,Q9UHX1,O95453 16 +Abnormal tongue morphology 0.3974651390534299 1.6159531293534732 0.1061044473375645 1.0 0.3290924392888663 57 Q96A33,Q9UBM7,O75844,P21912,Q7LGA3,P48651,P98175,Q9Y5P6,O43924,Q10713,P01889,P61978,Q05086,O75431 14 +Abnormal insulin level 0.4806746806737083 1.6155458427398577 0.1061925411771826 1.0 0.3291382077370137 24 O75844,P00367,O75431,Q16836,P31751 5 +Retinal coloboma 0.7235438074256859 1.610910206024064 0.1071992951971161 1.0 0.3315716311817072 7 O14936,Q10713 2 +Paroxysmal involuntary eye movements 0.5159446348473123 1.6083542631788523 0.107757612569993 1.0 0.3327199304069835 17 Q86Y39,O75306,O96000,Q9Y6M9,O43676 5 +Elevated urinary delta aminolevulinic acid 0.7783759825628751 1.6070818825528892 0.1080364070798749 1.0 0.3327199304069835 4 P16930 1 +Hepatitis 0.5061685572365785 1.6061919733199148 0.1082317364209528 1.0 0.3327199304069835 19 Q9H9C1,P08236,Q9H267,P25054 4 +Abnormal lung lobation 0.632507599654094 1.6057478432247052 0.1083293246140697 1.0 0.3327199304069835 11 P21964,Q9UBM7,Q14739 3 +Paralysis 0.4070909082228658 1.6056262691850378 0.1083560500734055 1.0 0.3327199304069835 45 P36551,P11166,Q8TB36,P35637,Q15165,P21912,Q15233,Q9NR77,P43243,Q92804,P04062,P16930,Q02978,P50402 14 +Titubation 0.6776134711266252 1.6031571240463254 0.1088999688680476 1.0 0.3327199304069835 9 P35637,Q99720 2 +Parkinsonism 0.4671828659839295 1.6031343933879905 0.1089049861336584 1.0 0.3327199304069835 27 P35637,Q99720,Q9NZJ7,O96008,P05067,P04062,P07602 7 +Difficulty walking 0.3853647736558513 1.6017160699253183 0.1092184099311157 1.0 0.3329974346269344 64 Q13057,P46976,Q9NR77,O14773,P35637,Q15067,O75298,Q8TD16,Q99720,Q15120,Q9BUK6,Q9H0B6,Q9NZJ7,Q8N0X7,P43243,P07602,O43681,Q9Y5P6,P31483 19 +Overtubulated long bones 0.697392266331673 1.5999576876726969 0.1096079703541801 1.0 0.333731730630638 3 O75844 1 +Emotional lability 0.401141759936872 1.5994959812706584 0.1097104408472233 1.0 0.3338172600151447 50 P35637,Q15165,Q9NZJ7,P49770,O75306,Q8N0X7,P43243,Q7KZN9,Q92804,P09651,O43681,P07602 12 +Endocarditis 0.7773590606225789 1.5945954012961183 0.110802741638369 1.0 0.3358982732989234 5 P04062 1 +Failure to thrive 0.3073480139582684 1.5912768097586103 0.1115472933969068 1.0 0.3373478792219123 251 Q9HC07,P37268,P13073,Q9H845,Q9H9C1,P21912,O75306,P98175,O75845,P35606,O96000,O43924,Q9Y6M9,Q7KZN9,Q9Y487,Q13546,Q15392,Q15067,Q9NX14,P21964,Q99707,P55263,Q13363,P42892,P55795,P36507,O14936,P00813,Q96EY8,Q15125,O95202,Q86Y39,Q9HCC0,Q99797,Q16625,Q96L58,P48651,Q9P0J0,Q5JTZ9,P28070,Q96J02,P40939,P04062,P16930,P06737,O43676,Q15800,Q9UBM7,Q14739,O75844,Q13423,Q9NZJ7,P51572,P46977,P07602,Q16836,O75381,Q9H267,Q15233 59 +Eeg with spike wave complexes 0.6005266253074659 1.5905309341320049 0.1117151785249519 1.0 0.3376280950976325 12 O14936,Q9NQZ5,Q14108,O75503 4 +Increased serum pyruvate 0.456573888455687 1.5897046524205762 0.1119013945012472 1.0 0.3379632964479123 29 Q86Y39,Q70HW3,Q5JRX3,P21912,O75306,O96000,Q9BWD1,O43676 8 +Venous insufficiency 0.7737899109326623 1.5878029224184225 0.1123309104426115 1.0 0.3385769819116458 4 P21964 1 +Varicose veins 0.7737899109326623 1.5878029224184225 0.1123309104426115 1.0 0.3385769819116458 4 P21964 1 +Birth length less than 3rd percentile 0.6946173562797511 1.587029518174323 0.1125059593531649 1.0 0.3388770104543654 3 Q9NXE4,Q9Y619 2 +Extra axial cerebrospinal fluid accumulation 0.6160322108345575 1.5864272849270926 0.1126424150483154 1.0 0.3390604686363779 2 Q03252 1 +Positive romberg sign 0.6960904341833976 1.5849415850555129 0.1129796070335129 1.0 0.3393737736970238 8 P41440,Q9H6K4,Q8IV08 3 +Abnormal thorax morphology 0.3224209693002068 1.5846363846887852 0.1130489731900736 1.0 0.3393737736970238 186 Q9Y619,Q32P28,Q8NCH0,P21912,P98175,P25054,P07196,O75845,Q8TAA9,P08236,P61978,Q9Y487,Q9UHX1,P51648,P11166,O75718,Q96A33,P21964,P16435,P02545,Q13363,P57740,P55795,P54802,P36507,O75431,P00813,P46783,P04066,Q9UM00,O00429,Q15125,Q8TD16,O95202,Q96L58,P41227,Q7LGA3,P48651,P50570,Q92917,Q96J02,P50542,P04062,O60313,Q9NVI7,Q9BUK6,Q9UBM7,Q14739,O75844,P78347,Q9Y5P6,P50402 52 +Impaired glucose tolerance 0.7729232840564779 1.5841572004268012 0.1131579502355033 1.0 0.33947385070651 4 O76024 1 +Brittle hair 0.5267687376127272 1.5823035142800297 0.1135802988730416 1.0 0.3398483295987892 16 Q9NVI7,P62266,O75844,P19447,P36507,P18074,Q9Y487 7 +Optic neuropathy 0.5026799379778865 1.58138409801379 0.1137902411795781 1.0 0.340233579223149 19 Q86Y39,Q9NX14,O75306,Q9P0J0,O96000,Q9Y6M9,O43676 7 +Aplasia hypoplasia affecting the eye 0.3589831347382455 1.580738096122862 0.1139379339156456 1.0 0.3404483671194526 81 P37268,P21912,P25054,P07196,O43924,P61978,Q02978,Q9UHX1,P11166,Q9NX14,P21964,Q13363,O14936,Q15125,O95202,Q7LGA3,Q9NVI7,O75312,Q9UBM7,Q9Y5P6 20 +Abnormality of the gastric mucosa 0.5538561040692674 1.5787960973466133 0.1143828340594863 1.0 0.3415503388283264 14 O76024,P04062,Q13546,Q14739 4 +Deformed sella turcica 0.7714837899871052 1.578099755683315 0.1145426943396188 1.0 0.3415731642499729 4 O75431 1 +J shaped sella turcica 0.7714837899871052 1.578099755683315 0.1145426943396188 1.0 0.3415731642499729 4 O75431 1 +Rhizomelia 0.6724335587211054 1.5774414208158154 0.1146939909744306 1.0 0.3417972320672277 9 Q15125,Q15392,Q14739 3 +Abnormal circulating sulfur amino acid concentration 0.6943630609181997 1.5766838798997478 0.1148682813845947 1.0 0.3419520033343056 8 P41440,P16930,P55263 3 +Sensory axonal neuropathy 0.5980238420170929 1.576366781073251 0.1149412993911263 1.0 0.3419520033343056 12 Q8IV08,Q15067,P22626,Q9H0B6 4 +Abnormality of neutrophil morphology 0.7729583359941148 1.5760332432633253 0.115018142181174 1.0 0.3419520033343056 5 Q14739 1 +Skin dimple 0.4855184975923959 1.5754050642277646 0.1151629762103274 1.0 0.342027167786707 22 P49366,Q15125,O95202,Q9NX14,P78347,Q13363,Q8TAA9,P53701,P27635,P61978,Q08J23,Q9UM00 12 +Broad phalanx of the toes 0.7706978012290765 1.574791351361258 0.1153046133826398 1.0 0.342027167786707 4 O14936 1 +Abnormality of the curvature of the vertebral column 0.3049930127920209 1.5735681512248765 0.1155873210993867 1.0 0.3426392979485123 257 Q9HC07,Q32P28,P50402,Q8TB36,Q8IWS0,Q8NCH0,P21912,O75027,P98175,P25054,Q8TAA9,P08236,Q9NR77,P01889,P61978,Q9Y487,P51648,Q96A33,Q14108,P35637,P21964,P16435,Q13363,P55795,Q10713,O14936,Q9UM00,Q15125,Q8TD16,O95202,Q99720,P22626,Q8NBU5,Q96L58,Q7LGA3,P48651,Q9NWM8,Q96J02,P04062,Q05086,Q9BT22,Q9NVI7,Q9BUK6,Q9UBM7,Q14739,O75844,Q9H0B6,Q8N0X7,P48449,Q01105,Q9Y5P6,Q15233 52 +Ambiguous genitalia 0.4963453243132018 1.5727274007014538 0.1157819523413665 1.0 0.3429897043617512 20 Q15392,Q9UBM7,P16435,O75845,Q8TAA9,P51809 6 +Stenosis of the external auditory canal 0.7719577000323581 1.5718095532696634 0.1159947253260358 1.0 0.3433933557145441 5 Q13363,P16435 2 +Proximal amyotrophy 0.5678992273057107 1.569229487768926 0.116594475587352 1.0 0.3441745613369359 13 P35637,Q16637,O14979,P07196,P02545,P50402 6 +Abnormality of hair pigmentation 0.4958352441916752 1.5690252861669467 0.1166420471910605 1.0 0.3441745613369359 20 Q05086,Q13126,P37268,Q9UBM7 4 +Profound global developmental delay 0.6925574323856702 1.568047058256531 0.1168701504745022 1.0 0.3445873761108077 8 P50542,O60313,O75381,P37268 4 +Spinal deformities 0.7688644688644697 1.567071904079972 0.1170978855331699 1.0 0.3445873761108077 4 Q9BQP7,Q8TB36,Q9Y5P6 3 +Abdominal pain 0.3673008406258549 1.5660668587615418 0.1173329657508193 1.0 0.3445873761108077 72 P36551,Q8NFH4,P35637,Q14108,Q8N1F7,Q70HW3,P21912,P23786,P25054,P42892,Q01844,P01889,O14936,P04062,Q02978,Q13546 16 +Dolichocephaly 0.4952357521351959 1.5646728070399996 0.1176596477118965 1.0 0.3445873761108077 20 P11766,O95202,O96028,Q13363,P40855,P27635,P50542,P61978,O75381,Q96J02 10 +Ileus 0.7678444285060158 1.5627753898186585 0.118105434694012 1.0 0.3450122603482534 4 P16930 1 +Large for gestational age 0.7130068701507738 1.562390074034674 0.1181961240027746 1.0 0.3450122603482534 7 P31751,Q9UM00 2 +Foot acroosteolysis 0.7677159777499474 1.5622342655897417 0.1182328111442989 1.0 0.3450122603482534 4 O75431 1 +Osteolysis involving bones of the feet 0.7677159777499474 1.5622342655897417 0.1182328111442989 1.0 0.3450122603482534 4 O75431 1 +Vertebral segmentation defect 0.4660862539940372 1.5605711210371704 0.1186249770683716 1.0 0.3450481767194413 26 Q15125,O95202,P78347,P16435,Q13363,Q8TAA9,P61978,Q9UHX1,Q9UM00 9 +Maturity onset diabetes of the young 0.6109077598828742 1.559622315686799 0.1188491597994714 1.0 0.3450481767194413 2 P61457 1 +Corneal erosion 0.7670616611900047 1.5594775633256792 0.1188833909159758 1.0 0.3450481767194413 4 P01889,P51648 2 +Proximal muscle weakness in upper limbs 0.5659285353891506 1.5574738903732268 0.1193580148830686 1.0 0.3450481767194413 13 P36551,P50570,P07196,Q9Y5P6,P50402 5 +Undetectable electroretinogram 0.7685481240837573 1.5574094686390023 0.1193732995080383 1.0 0.3450481767194413 5 O14773,P50897,O43924 3 +Postaxial hand polydactyly 0.6460230136992082 1.5568075397372911 0.1195161865721559 1.0 0.3451664384400487 10 Q9UBM7,Q14739,O43924,Q10713,Q9UM00 5 +Abnormality of the upper respiratory tract 0.3569903951891102 1.5540089178299028 0.1201822894504496 1.0 0.346421396951585 81 P01889,P35637,Q9UBM7,Q14739,P21964,Q15165,Q9NZJ7,P09651,P16435,Q13432,P25054,P28070,P08236,P54802,Q92804,P07602,P43243,Q9UHX1 18 +Abnormality of the diencephalon 0.4880548941078974 1.5515769425555512 0.120763483753342 1.0 0.3474272532596147 21 Q13057,P11166,O75306,Q92917,O43924,Q9Y5P6 6 +Head titubation 0.7316828122473438 1.550743827283936 0.1209630869605713 1.0 0.347555911830374 6 Q99720 1 +Loss of speech 0.5074452081909124 1.549938879074075 0.1211561868215196 1.0 0.3478880143665899 17 P07602,O43681,Q9NZJ7,O15118 4 +Nasogastric tube feeding in infancy 0.7100031566220611 1.548529929472252 0.1214947615684129 1.0 0.3484143705552955 7 P07602,P61978,Q9NZJ7 3 +Elevated circulating follicle stimulating hormone level 0.686204570679853 1.5477758248792497 0.1216762788910714 1.0 0.3484895594531772 3 P16435 1 +Abnormal peripheral nervous system physiology 0.4013216035217717 1.5457196260176826 0.1221722952827966 1.0 0.3492415676619052 45 Q15125,Q9NQZ5,Q8TB36,Q99720,Q9NZJ7,Q15120,O15269,Q9NR77,P43243,P07602,O43681,O60313 12 +Raynaud phenomenon 0.7299368478357944 1.5429665145834888 0.1228389007097332 1.0 0.3509236068652341 6 Q14739 1 +Alkalosis 0.7627320222916067 1.5412253859039136 0.123261941121207 1.0 0.3514609858652968 4 P01889 1 +Abnormal csf protein level 0.6868720023628764 1.5408192908011709 0.1233607730885506 1.0 0.351519460077089 8 P07602,O43681,Q9NZJ7,Q9NR77 4 +Abnormality of pelvic girdle bone morphology 0.3365622513624736 1.5386332728766725 0.1238938508338756 1.0 0.3528144686182955 119 Q8IWS0,Q9H9C1,P25054,Q8TAA9,P08236,P01889,P61978,Q9Y487,Q9UHX1,Q96A33,P16435,Q13363,O75431,P00813,Q15125,Q8TD16,O95202,Q8NBU5,Q96L58,Q7LGA3,Q8IZA0,Q6NUQ1,P50542,Q9NVI7,Q9UBM7,Q14739,O75844,Q9Y5P6,Q9H267 29 +Scotoma 0.6197186091947798 1.5367651173860155 0.1243508384502416 1.0 0.3536094558297826 11 Q9H6K4,Q9H061,O75306,Q8WWV3 4 +Abnormality of circulating leptin level 0.7612760440921523 1.5350833146835654 0.124763364247695 1.0 0.3540669856826629 4 P31751 1 +Cutis laxa 0.4588243392210214 1.5346377983403952 0.1248728225992539 1.0 0.3540669856826629 27 Q9NX14,Q8NCH0,Q96L58,P48651,P38435,O96000,P36507,Q9Y487 8 +Abnormal circulating ferritin concentration 0.7609181695581719 1.5335732969622125 0.1251346617991791 1.0 0.3540669856826629 4 P36551 1 +Abnormal femoral neck head morphology 0.4209133201586261 1.5333475222812174 0.1251902513779488 1.0 0.3540669856826629 35 Q96A33,Q14739,O75844,Q96L58,O75431,Q9Y487 6 +Prematurely aged appearance 0.4192783193190641 1.533189648014718 0.1252291341512275 1.0 0.3540669856826629 36 P11166,Q13126,P78347,O75844,P41227,P48651,P02545,P19447,P36507,O75431,Q9Y487,O95453 12 +Optic disc coloboma 0.6830518280278358 1.533043518257492 0.1252651327636877 1.0 0.3540669856826629 3 Q10713 1 +Motor axonal neuropathy 0.5463799794940971 1.5324927043048786 0.1254008965786086 1.0 0.3540669856826629 14 Q13057,P22626,Q9H0B6,O15269,P09651,O60313 6 +Cavernous hemangioma 0.7624593153647605 1.5316630136026337 0.1256056139571124 1.0 0.3540669856826629 5 P21912,P36507 2 +Psychomotor deterioration 0.6849182311497569 1.5314513759860504 0.1256578749566272 1.0 0.3540669856826629 8 P07602,Q9NZJ7,Q9Y487 3 +Sensorimotor neuropathy 0.4584282405549244 1.53138266491397 0.1256748458539398 1.0 0.3540669856826629 27 Q9Y2R0,Q9NZJ7,Q15120,P41440,Q9NR77,P40939,O60313,P07602 8 +Increased head circumference 0.3451110810988244 1.528180741034117 0.1264676691055732 1.0 0.3553703009638733 95 Q8IWS0,P21912,P25054,P08236,P11166,Q15392,O60488,P55263,Q10713,P36507,Q13153,Q9UM00,Q8TD16,P50570,Q7LGA3,P48651,P49770,Q96J02,Q05086,Q13555,Q14739,O75844,Q9NZJ7,P07602,O75381,Q15233 26 +Supernumerary tooth 0.7054326508358558 1.5274166922194 0.1266574283058255 1.0 0.3554962715675702 7 O60488,Q9UHX1,Q9UBM7,P25054 4 +Ankylosis 0.7611510453373447 1.5261260059535868 0.1269784866000058 1.0 0.355952184797518 5 O75844,P48651,P16435 3 +Erythroderma 0.6616441047942853 1.523728533091855 0.1275765386937291 1.0 0.3573960099216194 9 Q15125,O75352,P19447,P48449,P00813 5 +Abnormal vitamin b12 level 0.7605126315471283 1.5234234120747192 0.1276528083565855 1.0 0.3573960099216194 5 P41440,Q96EY8 2 +Hyperextensible skin 0.5447522268357375 1.522389257612468 0.1279115749006432 1.0 0.3578972245349667 14 Q8NCH0,Q96L58,Q9NWM8,P04062,Q9UHX1 5 +Tube feeding 0.3940322972996876 1.5213326556421374 0.1281763793621293 1.0 0.3584146981789635 49 P35637,Q96N66,P37268,Q99720,Q9NZJ7,Q01105,P07602,P61978,Q15233 9 +Hypermethioninemia 0.7598050611889335 1.5204275813988668 0.128403546832819 1.0 0.3585796621388253 5 P55263 1 +Abnormal atrioventricular valve physiology 0.4102944671326825 1.518505198644784 0.128887089959139 1.0 0.3593872423131141 40 P40939,Q9NX14,P78347,O75844,Q96L58,O75306,P09493,P02545,O43819,P01889,O75431,P04062,Q15233 13 +Nonprogressive 0.7244174032028992 1.5183564353662993 0.1289245677638399 1.0 0.3593872423131141 6 Q9NQZ5 1 +Hip pain 0.758514333088928 1.5149613991099116 0.1297821798262104 1.0 0.3604346677351686 5 O75844,P22626,P09651 3 +Ragged red muscle fibers 0.5300571717616944 1.5130516629363675 0.1302665363903239 1.0 0.3615561010017153 15 Q9H2D1 1 +Rieger anomaly 0.7557604299850837 1.5117971152110492 0.1305854835271687 1.0 0.3619936072081119 4 Q13363 1 +High narrow palate 0.4673794015102701 1.511392703874491 0.1306884271606436 1.0 0.3620553463561535 24 Q9Y619,P41227,P48651,P16435,P23786,P25054,P19447,P50542,P61978,Q15233 10 +Chronic fatigue 0.7569392209320458 1.508288647334076 0.131480667515953 1.0 0.3640254385019105 5 P07602,Q9NZJ7 2 +Abnormal external genitalia 0.3089997975424867 1.5077407220308157 0.1316208988560931 1.0 0.3641890222356018 235 Q8IWS0,P37268,Q8NCH0,P21912,P98175,O75845,Q8TAA9,O43924,Q01844,P01889,P61978,Q96EK5,Q9Y487,Q86XL3,Q9UHX1,O95470,Q15392,Q06136,P21964,P16435,Q13363,O76024,P42892,Q10713,O14936,Q9UM00,Q15125,O95202,Q7LGA3,P48651,Q9UBX3,P38159,Q9NVI7,O75312,Q9UBM7,O75844,Q13423,P48449,P46977,P51809,O75381,Q9Y5P6,Q15233 43 +Heparan sulfate excretion in urine 0.7543591401269023 1.5058765280230155 0.1320988730705379 1.0 0.3650633785850762 4 P08236 1 +Increased urine alpha ketoglutarate concentration 0.7543584861543444 1.5058737645073197 0.1320995826252593 1.0 0.3650633785850762 4 P00367 1 +Proximal symphalangism 0.6766861522187324 1.5032639070675675 0.13277100351196 1.0 0.3664675668891 3 Q15233 1 +Symphalangism affecting the phalanges of the hand 0.6766861522187324 1.5032639070675675 0.13277100351196 1.0 0.3664675668891 3 Q15233 1 +Soft skin 0.6786412446616704 1.5013171553698024 0.1332735498709092 1.0 0.3674027591035876 8 Q13126,Q9NWM8 2 +Respiratory failure 0.382965400544774 1.499430175608253 0.1337620701995547 1.0 0.3676128781085668 60 Q8TD16,Q9BT22,P35637,Q16637,Q9NX14,Q70HW3,Q8NBU5,Q15165,Q9NZJ7,O75306,P23786,P43243,Q92804,P40939,P07602,Q9Y5P6 16 +Depression 0.3517688598603154 1.498975992434625 0.133879860307845 1.0 0.3676128781085668 83 P36551,Q13057,P50897,P01889,P11166,P35637,P21964,Q15165,O76024,P09651,Q96N66,Q5JTZ9,Q92804,P04062,Q9BUK6,P78347,Q9NZJ7,P43243,P07602,O43681 20 +Epiphyseal stippling 0.5838909505153537 1.4961015687302803 0.1346271891893131 1.0 0.3686435784512736 12 Q15125,Q9UBM7,Q14739,P08236,P50542,P38435,O75381 7 +Hypopigmentation of the skin 0.4099543124459996 1.4954995377347169 0.1347841204610942 1.0 0.3688482516032871 39 Q15125,P53634,O75312,Q9NX14,P21964,P21912,Q9NZJ7,P02545,Q8IZA0,P19447,P53701,P07602,Q05086,O95453 14 +Generalized hyperkeratosis 0.7536309893974644 1.4942660060084836 0.1351061064818983 1.0 0.3695040864660328 5 O75844,P02545,P21912 3 +Nuclear cataract 0.7514218172516041 1.4934603121318706 0.135316735626032 1.0 0.3698547560838197 4 O76024,P08670 2 +Abnormal circulating metabolite concentration 0.3086753364808843 1.490231786221816 0.1361633013155405 1.0 0.3713151782876054 301 Q9HC07,P36551,P37268,Q9H845,Q9H9C1,P21912,O75306,P23786,P07196,P41440,O96000,Q9Y6M9,Q9Y487,Q02978,P11166,O95470,Q15392,Q70HW3,P21964,Q99707,Q9H0R6,P55263,P00367,Q9BWD1,P05067,O75431,O14936,Q8N511,Q96EY8,Q15125,Q86Y39,P22626,Q9NWM8,Q15120,P28070,Q6NUQ1,P40939,P16930,P31751,O43676,Q8N1F7,Q8NFH4,Q15800,Q9BT22,Q9NVI7,Q9BUK6,O14979,Q14739,O75844,Q9UBM7,Q9NZJ7,Q5JRX3,O75312,Q13423,O43772,P42167,Q9Y5P6,P43243,P06737,P07602,Q16836,O75381,Q9H267,P50402,P31483 65 +Portal fibrosis 0.7506415208452757 1.4901606782736474 0.1361819927498659 1.0 0.3713151782876054 4 P55263,P06737 2 +Abnormality of the tongue 0.3569686615335463 1.4869704300176805 0.1370226209540019 1.0 0.3729275456892424 74 P21912,P98175,P07196,O43924,P40855,P01889,P61978,Q96A33,Q16637,P02545,Q10713,O75431,P04066,Q7LGA3,P48651,P50542,Q05086,Q9UBM7,P78347,O75844,O75381,Q9Y5P6 22 +Nephrocalcinosis 0.5388648252349181 1.4857829070590225 0.1373365527610619 1.0 0.3732120823118039 14 Q9H9C1,P16930 2 +Abnormality of coordination 0.3041619764480908 1.4856314184557646 0.1373766399240419 1.0 0.3732120823118039 274 P50897,P21912,O75306,O15118,P25054,O75027,P41440,P07196,O96000,O43924,Q9NR77,Q9Y6M9,Q8IV08,P01889,Q7KZN9,Q9Y487,P11166,O14773,Q14108,P35637,Q15067,O95470,Q9NX14,Q99707,O14949,Q13363,O76024,P55795,Q10713,P05067,O14936,Q13153,O75503,O75298,Q9NQZ5,O95202,Q86Y39,Q6P4A7,Q99720,Q8NBU5,Q96IX5,Q9P0J0,Q5JTZ9,P40939,P50542,P04062,O60313,Q05086,O43676,Q9NVI7,Q9BUK6,Q5JRX3,Q9NZJ7,O96008,Q8N0X7,Q9H6K4,Q01105,Q15233,P07602,O43681,O75381,Q9Y5P6,Q8WWV3,P31483 64 +Kinetic tremor 0.4347981517015722 1.4847412609038624 0.1376123771951902 1.0 0.3736263453430211 31 Q14108,Q9NZJ7,P07602,O43681,Q15233 5 +Abnormal ureter physiology 0.4124377640624305 1.4840983718551326 0.1377828251039001 1.0 0.3738028320370112 37 Q9UBM7,P21964,P21912,P16435,P35606,Q8TAA9,Q86XL3 7 +Abnormality of the intrahepatic bile duct 0.7490842490842501 1.4835738811023107 0.1379220028177217 1.0 0.3738028320370112 4 P50542,P02545,Q10713 3 +Frequent falls 0.420427739210551 1.483554121933094 0.1379272481847795 1.0 0.3738028320370112 34 P21912,Q9NZJ7,Q9NR77,P40939,O43681,P04062,P07602 7 +Tremor 0.3275299028360511 1.4807774598012375 0.1386658848401205 1.0 0.3750399933887907 144 P21912,O75306,O75027,P07196,P41440,O43924,Q9NR77,Q02978,P11166,O14773,Q14108,P35637,O76024,Q10713,O14936,O75503,Q9NQZ5,Q6P4A7,Q99720,Q15120,P04062,O60313,Q05086,Q9BUK6,Q5JRX3,Q9NZJ7,Q9H6K4,P07602,O43681,Q15233 30 +Abnormal circulating methionine concentration 0.7158069306614248 1.4798947625796732 0.138901333628183 1.0 0.3750399933887907 6 P16930,P55263 2 +Abnormality of the lower urinary tract 0.3168498776950192 1.4779618218903785 0.1394179973290079 1.0 0.3750399933887907 183 P37268,Q8NCH0,P21912,P07196,Q8TAA9,P35606,Q9NR77,P01889,P61978,Q96EK5,Q86XL3,Q9UHX1,P11166,P35637,Q9NX14,P21964,O60488,P16435,Q13363,O76024,P09651,O75298,O95202,Q99720,P22626,P50570,P48651,Q9NWM8,Q9UBX3,P04062,Q9UBM7,O75844,Q9NZJ7,Q8N0X7,P48449,P07602,O43681,P51809,O75381 39 +Abnormal cellular phenotype 0.319806098587844 1.4765200123514295 0.1398043469116414 1.0 0.3750399933887907 162 Q9Y2R0,Q9H845,P13073,P21912,O75306,P23786,O96000,Q9Y6M9,P17812,P46976,Q7KZN9,Q13546,P11166,O14773,Q14108,P35637,Q9NX14,Q70HW3,P21964,Q9H0R6,P09601,P00813,O75503,Q86Y39,Q9P0J0,Q9UBX3,P28070,Q96J02,P40939,P50542,P04062,O43676,Q14739,O75844,Q9NZJ7,O43772,P07602,Q16836 38 +Abnormal delivery 0.4829543662578154 1.4751782232989787 0.1401646344904878 1.0 0.3757818874512005 20 Q9Y619,O75718,Q9UBM7,Q9Y487,P50570,O75844,O60313 7 +Brisk reflexes 0.4776938948415194 1.4745727175708665 0.1403274542569395 1.0 0.3759937998239668 21 Q5JRX3,P35637,Q99720,Q9BSJ2 4 +Diffuse white matter abnormalities 0.6938835057497653 1.4739468958920574 0.1404958898012089 1.0 0.3761050312630304 7 Q3ZCQ8,O75306,O43819,O14936,Q9Y5P6 5 +Mitochondrial myopathy 0.4718328590723517 1.4717377736272408 0.1410917029826472 1.0 0.3773656513624082 22 Q86Y39,Q9BUK6,O75306,O96000,Q9Y6M9,O60313,O43676 7 +Hepatomegaly 0.3266295555392174 1.471255030850582 0.141222159736803 1.0 0.3774108444150831 145 Q9HC07,P36551,O75306,O15118,P23786,O96000,P08236,Q9Y6M9,Q01844,Q13546,P11166,Q96A33,Q14108,Q15067,P09601,P54802,Q10713,O75431,Q96EY8,Q86Y39,P28070,Q6NUQ1,Q96J02,P40939,P04062,P16930,P31751,O43676,Q9BT22,Q14739,Q9NZJ7,O43772,P06737,P07602,O75381 35 +Hemivertebrae 0.6075935260772848 1.471052990864547 0.1412767866794428 1.0 0.3774108444150831 11 Q15125,Q9UHX1,P16435,Q9UM00 4 +Focal t2 hyperintense brainstem lesion 0.5234553931227099 1.4705530708956365 0.1414120232886451 1.0 0.3775473887682565 15 Q86Y39,Q9NX14,O75306,O96000,Q9Y6M9,O43676 6 +Abnormality of hepatobiliary system physiology 0.3655365139522987 1.4695819448550678 0.1416750132124471 1.0 0.378020237185438 69 Q9Y619,Q9H845,P53004,O75306,O15118,P23786,O75845,P01889,Q96A33,P28288,Q9H0R6,P55263,Q10713,Q8N511,Q16625,Q6NUQ1,Q96J02,P40939,P50542,P04062,P16930,Q9BT22,O43772,Q16836,O75381 25 +Osteolytic defects of the distal phalanges of the hand 0.7457058705803915 1.469277308465812 0.1417575889445392 1.0 0.378020237185438 4 O75431 1 +Ectrodactyly 0.5228522901473845 1.4666641428948637 0.1424674417115075 1.0 0.3794622423746265 15 O95202,Q8TB36,Q99720,Q9UBM7,Q13363,P48449,Q9NR77 7 +Dysesthesia 0.7470167766525555 1.4662000102584571 0.1425938058220452 1.0 0.3795735471704266 5 Q8NCH0 1 +Mottled pigmentation 0.6683562859375176 1.4642325516607348 0.1431304189454691 1.0 0.3805505451583327 3 O75844 1 +Progressive gait ataxia 0.6493458505411464 1.462276499838305 0.143665455606607 1.0 0.3809211546492223 9 P07602,O43681,Q9NZJ7,Q05086 4 +Delayed puberty 0.3957660375873716 1.462065409806787 0.1437232864022877 1.0 0.3809211546492223 44 Q15800,Q14108,Q9NVI7,O75844,P51809,P16435,O76024,P06737,P04062,Q15233 10 +Hyperactive patellar reflex 0.6906837130281652 1.45910426709525 0.1445364119722874 1.0 0.3809211546492223 7 P21912,Q5T440,P13073,Q15233 4 +Abnormal dermatoglyphics 0.3779595749322016 1.4582878537052757 0.1447612167593166 1.0 0.3812725004787635 61 Q8NCH0,P98175,P25054,P40855,P61978,Q9Y487,Q9UHX1,Q99567,Q13363,P57740,P36507,O75431,O95202,Q92917,Q96J02,P50542,P62266,P78347,Q9UBM7,O75381 20 +Abnormal brainstem mri signal intensity 0.4897190127917693 1.4564084389248035 0.1452797440827504 1.0 0.381417855967175 18 O96000,Q86Y39,O75306,O43676 4 +Diabetes insipidus 0.6048549161029146 1.456172190553576 0.1453450251188162 1.0 0.381417855967175 11 P01889,Q9H9C1,Q9H267 3 +Pectus excavatum 0.371365883397882 1.454585896776056 0.1457839377173113 1.0 0.382020211691685 65 Q8NCH0,P21912,P98175,P61978,Q9Y487,Q9UHX1,Q96A33,O75718,P02545,P57740,P36507,O75431,Q96L58,Q7LGA3,Q96J02,P04062,Q9BUK6,P78347,P50402 19 +Aganglionic megacolon 0.5764716938508303 1.4537843280252372 0.146006109805298 1.0 0.382020211691685 12 P21964,Q10713,P42892,Q9UBM7 4 +Frontotemporal dementia 0.6042807448150621 1.4530505834038896 0.1462097100655193 1.0 0.382020211691685 11 P35637,P22626,O96008,P05067,P31483 5 +Subcutaneous hemorrhage 0.4262396973319903 1.4529530421738606 0.1462367922652216 1.0 0.382020211691685 32 Q13126,Q14108,P21964,Q8NCH0,Q96L58,Q9NWM8,P04062 7 +Hypertensive crisis 0.7414038394948146 1.4510586599536153 0.1467635266335429 1.0 0.3827278951373276 4 P21964 1 +Abnormal vertebral morphology 0.3420559682760182 1.4490882512037595 0.1473129386250102 1.0 0.3837147234759409 92 Q32P28,Q8IWS0,Q8NCH0,P25054,O75845,Q8TAA9,P08236,P61978,Q9UHX1,Q14108,P16435,Q13363,P54802,Q10713,Q9UM00,Q15125,O95202,Q96L58,Q6NUQ1,Q96J02,P04062,Q9UBM7,Q14739 23 +Fibrous tissue neoplasm 0.519841928782281 1.4472369707394142 0.1478305652347236 1.0 0.3846165662454722 15 Q13126,P21912,Q15392 3 +Vertebral compression fracture 0.5196994777491742 1.4463170288937808 0.1480883016197445 1.0 0.3850639036323368 15 Q32P28,Q14108 2 +Abnormal circulating fatty acid concentration 0.4923744815342945 1.4456968290285896 0.1482622541478204 1.0 0.3852929916707691 17 P40939,Q9H845,O43772,P23786,P50542,O75431,Q16836,O75381 8 +Abnormal heart rate variability 0.739760748691054 1.4440965615817922 0.1487118151616799 1.0 0.3857419534046351 4 Q9NZJ7 1 +Abnormal arterial physiology 0.4587819726532599 1.443594281259403 0.1488531345131301 1.0 0.3857419534046351 24 P05067,Q9NWM8,O75844,Q14739 4 +Urticaria 0.6666193760457721 1.4434534923101827 0.1488927646554092 1.0 0.3857419534046351 8 P18074,P21912,P51648,P19447 4 +Abnormal circulating carbohydrate concentration 0.416091728405878 1.4432929674141046 0.1489379600211837 1.0 0.3857419534046351 34 Q86Y39,Q70HW3,Q5JRX3,P21912,O75306,O96000,Q9BWD1,O43676 8 +Abnormal sternal ossification 0.7395604395604405 1.4432476739136917 0.1489507141823156 1.0 0.3857419534046351 4 Q13363,O95202,Q9Y619 3 +Microglossia 0.7388851567565944 1.4403856820855867 0.1497583122177808 1.0 0.3873863430740059 4 Q9UBM7 1 +Aplasia hypoplasia of the tongue 0.7388851567565944 1.4403856820855867 0.1497583122177808 1.0 0.3873863430740059 4 Q9UBM7 1 +Kyphoscoliosis 0.3884759504573916 1.4344913640092924 0.1514320917899132 1.0 0.3910398319638266 47 Q9HC07,Q8NBU5,O75844,Q8NCH0,Q96L58,Q9NWM8,Q8N0X7,Q9NR77,Q9Y487,Q15233 10 +Pedal edema 0.7054683932764945 1.433611634208267 0.1516831215872089 1.0 0.3912234846656851 6 Q14108 1 +Poor head control 0.3742570564619421 1.43233601796974 0.1520476798533134 1.0 0.3912234846656851 62 P13073,Q96CU9,P21912,O75306,O96000,Q9Y6M9,P06865,Q9NX14,P02545,Q10713,O14936,Q86Y39,Q9NWM8,Q9P0J0,Q9NQT5,O43676,Q9NZJ7,O60231,P07602,Q9Y5P6,Q15233 21 +Onion bulb formation 0.6849021403062852 1.432256849071321 0.1520703274929424 1.0 0.3912234846656851 7 P50570,Q8TB36,Q9NR77,P07196 4 +Underdeveloped supraorbital ridges 0.6004538916857917 1.4322301268653883 0.1520779724241852 1.0 0.3912234846656851 11 P98175,P16435,P40855,P36507,P50542,O75381 6 +Progressive psychomotor deterioration 0.6642858983950622 1.4322007914877954 0.1520863652922113 1.0 0.3912234846656851 8 P07602,O43681,Q9NZJ7,P21912 4 +Ascending tubular aorta aneurysm 0.7388222128645114 1.43137611643464 0.152322449610581 1.0 0.3912234846656851 5 O75844,Q96L58 2 +Ectopic calcification 0.3852073060813832 1.430680609883821 0.1525217728868628 1.0 0.3912234846656851 52 P23786,O75845,P08236,P40855,P11166,P02545,P05067,O75431,P38435,O95453,Q15125,P53634,Q16625,P50542,P04062,O60313,Q9UBM7,Q14739,O75844,O75381 20 +Pericardial effusion 0.736529604288656 1.430399753736433 0.1526023189031624 1.0 0.3912234846656851 4 Q14108 1 +Fetal ultrasound soft marker 0.544679145391513 1.4300668273057462 0.1526978399449652 1.0 0.3912234846656851 13 Q15125,P16435,P50542,P61978,O75381 5 +Insidious onset 0.7363838027808551 1.429781524919871 0.1527797332053799 1.0 0.3912234846656851 4 P04062,Q9NR77 2 +Retinal vascular tortuosity 0.6634652584533065 1.428241887483391 0.1532222479384126 1.0 0.3916067475783577 8 O75306 1 +Functional abnormality of the gastrointestinal tract 0.3072432408833366 1.4272521868027797 0.1535072169500613 1.0 0.3919092575885263 228 P36551,P21912,O75306,O15118,P25054,Q9NR77,Q01844,P01889,P61978,Q13546,Q96A33,Q14108,P35637,Q15067,P21964,P16435,Q13363,O76024,P42892,P55795,P05067,Q86TI2,O95202,Q99720,Q8NBU5,Q96J02,P04062,P16930,O60313,P08183,Q05086,Q9UBM7,Q14739,Q9NZJ7,Q8N0X7,O15269,Q01105,P07602,Q15233 39 +Acanthosis nigricans 0.6423506896611356 1.4272242827868973 0.1535152573174307 1.0 0.3919092575885263 9 O75431,P28070 2 +Ureteral duplication 0.70388581056234 1.4265177252067556 0.1537189541833279 1.0 0.3919833331674862 6 O75844,P23786 2 +Late onset 0.6416674710581599 1.4237971617981002 0.1545051975484344 1.0 0.3937645239053796 9 P43304,Q9Y6M1,O76024,P31751,P31483 5 +Spastic paraparetic gait 0.6588063644917228 1.4194071916883906 0.1557803369549197 1.0 0.3965638980451956 3 Q15041 1 +Widely patent fontanelles and sutures 0.7337592253267998 1.4186502467143518 0.1560010090749028 1.0 0.3969005264898889 4 O75844,P98175 2 +Abnormality of the peripheral nervous system 0.3438236734280424 1.4148710426616202 0.1571063096415244 1.0 0.3990340224511383 86 Q8TB36,P07196,P41440,Q9NR77,Q15067,P21964,O76024,P42892,Q10713,Q15125,Q9NQZ5,Q99720,Q15120,P04062,O60313,Q9UBM7,Q9NZJ7,O15269,P43243,P07602,O43681 21 +Squamous cell carcinoma of the skin 0.73271733189556 1.4142301051214166 0.1572943513914848 1.0 0.3992856612245384 4 P02545,P19447 2 +Restlessness 0.4066119013545876 1.4125952999210227 0.1577747518080754 1.0 0.4002787372044333 36 P35637,Q15165,O96008,P48449,P42892,P43243,Q92804,P05067,P04062 9 +Abnormality of the elbow 0.3836891261210571 1.410429564891618 0.1584128806797675 1.0 0.4013549663127156 50 Q9Y619,P50402,P37268,Q96L58,Q7LGA3,P48651,P16435,P23786,P25054,P02545,Q9H6K4,P36507,P50542,Q96J02 14 +Cryptorchidism 0.3244358568195091 1.4083694989675963 0.1590216860117552 1.0 0.4020784939835254 140 Q8IWS0,P37268,Q8NCH0,Q8TAA9,O43924,P61978,Q9Y487,Q86XL3,O95470,P21964,P16435,Q13363,Q15125,O95202,Q7LGA3,P48651,Q9NVI7,Q9UBM7,Q13423,P48449,P46977,P51809,O75381,Q9Y5P6,Q15233 25 +Nephrotic syndrome 0.4541196310781073 1.4066907446526258 0.1595191113934699 1.0 0.402393452647555 24 Q9BT22,Q14108,O95470,Q8NCH0,P51809,Q8N1F7 6 +Long fingers 0.3622829583694344 1.406522783619335 0.1595689439921501 1.0 0.402393452647555 68 Q15125,Q8IWS0,P53634,O95202,Q06136,Q8NCH0,P21964,Q96L58,P16435,P23786,Q13363,P42892,P55795,Q96EK5,Q9UHX1 15 +Prenatal maternal abnormality 0.540680592088844 1.4059689968947706 0.1597333311800051 1.0 0.4025172320807764 13 P49366,Q14739,O43772,P16435,Q8TAA9,P40939 6 +Hammertoe 0.4999685807354806 1.4036105454726682 0.1604348531572028 1.0 0.4036051687048914 16 Q8TB36,Q99720,Q9UBM7,Q8N0X7,Q9NR77 5 +Hyperhomocystinemia 0.6551445889543984 1.4022006013258128 0.1608553521457441 1.0 0.4044363139664423 3 P41440 1 +Plagiocephaly 0.4464847016705094 1.4013739612683749 0.1611022745773482 1.0 0.4048303517934709 26 Q96A33,Q96L58,Q01105,O14936,Q15233 5 +Abnormal urinary color 0.7312878439690069 1.3993120542919852 0.161719426423827 1.0 0.4061236420239961 5 P36551,P23786 2 +Generalized muscle weakness 0.4341808865326992 1.399050227841266 0.1617979215550145 1.0 0.4061236420239961 29 P40939,P35637,Q9H845,Q15165,P21912,P43243,Q92804,P09651 8 +Gastrostomy tube feeding in infancy 0.4574351326358609 1.3956744063112718 0.1628125648204628 1.0 0.4079859245752301 23 Q01105,P35637,P37268,Q99720 4 +Synostosis of joints 0.4376698356313485 1.3929057815913242 0.1636482838777431 1.0 0.4090430831567612 28 O95202,Q96L58,P48651,P16435,P25054,Q13363,Q8TAA9,Q9UHX1,Q15233 9 +Abnormal pericardium morphology 0.6354868995888041 1.39276737705486 0.1636901464682583 1.0 0.4090430831567612 9 P04062,Q14108 2 +Aplasia hypoplasia of the skin 0.3811767047825191 1.3887743025823822 0.1649013917420019 1.0 0.4109258446074983 53 Q15125,P53634,O95202,Q13126,Q15392,O75844,Q8NCH0,Q96L58,Q9NWM8,Q13363,O75431 11 +Very long chain fatty acid accumulation 0.7273726639794897 1.3826346828003917 0.1667769088973032 1.0 0.4146785413468681 5 P50542,P51659,O75381,P40855 4 +Occipital meningocele 0.7249770015429605 1.3813710501855698 0.1671649024124815 1.0 0.4153620258156204 4 P21964 1 +Abnormal liver morphology 0.3100779172009211 1.3806514748876104 0.1673861480989096 1.0 0.4155027835552579 203 Q9HC07,P36551,Q9H845,Q9H9C1,O75306,O15118,P23786,P25054,O75845,O96000,P08236,Q9Y6M9,Q7KZN9,Q01844,Q13546,P11166,Q96A33,Q14108,Q15067,P28288,Q9NX14,P55263,P09601,P54802,Q10713,P09651,O75431,Q8N511,Q96EY8,P53634,Q86Y39,P22626,P28070,Q6NUQ1,Q96J02,P40939,P04062,P16930,P31751,O43676,Q9BT22,Q9NVI7,O75312,Q14739,Q9NZJ7,O43772,P06737,P07602,Q16836,O75381,Q9H267 51 +Abnormal sacrum morphology 0.4361276260379901 1.3798932556795578 0.1676195134613065 1.0 0.4158503229872666 28 P49366,Q15125,O95202,Q9NX14,Q14739,P78347,Q13363,Q8TAA9,P53701,P27635,P01889,P61978,P04066,Q9UM00 14 +External ear malformation 0.5906522652991049 1.3787910223841158 0.1679591954980326 1.0 0.416234604856527 11 P50542,Q8NCH0,O75381,P40855 4 +Upper limb asymmetry 0.5750366032210897 1.371089217947696 0.1703471456596315 1.0 0.4207583872979781 2 Q15555 1 +Abnormality of the autonomic nervous system 0.3835595811135017 1.370379703993148 0.1705684043029773 1.0 0.421073156497119 46 Q15067,Q9UBM7,P21964,Q9NZJ7,P41440,O76024,P42892,O15269,Q10713,P07602,O43681,P04062 12 +Abnormality of circulating adrenocorticotropin level 0.7241529547977783 1.3689125624184582 0.1710266084132992 1.0 0.4219721927206634 5 P16435 1 +Brachydactyly 0.3787870726466395 1.365224128981999 0.1721826168101294 1.0 0.4238922568534619 54 P11166,Q9UBM7,Q14739,Q06136,P21912,P48651,P16435,Q8N0X7,P48449,O43924 10 +Abnormality of neuronal migration 0.3251145832104593 1.3644084970039592 0.1724390351198053 1.0 0.4240582956809239 123 P37268,Q15392,Q96N66,Q9UBM7,P61978,Q9H9C1,Q9BSJ2,P23786,P35606,O43924,Q01105,Q10713,O14936,Q9Y487,O75381,Q86XL3,Q9H267 17 +Thin nail 0.5732064421669171 1.3614394863112844 0.1733748448115413 1.0 0.4255412951710984 2 Q9H1A4 1 +Lower limb hyperreflexia 0.4936700280618923 1.3612922465944024 0.1734213522433019 1.0 0.4255412951710984 16 Q15233,Q05086,P13073,Q14739 4 +Babinski sign 0.342476271772256 1.3578042181578116 0.1745258161203031 1.0 0.4272733300725502 81 P11166,P40939,P35637,Q15067,Q99720,O14773,Q9NZJ7,P21912,O60488,O75027,P07196,Q8N0X7,P41440,Q9H6K4,Q9NR77,P07602,O43681,O60313 18 +Abnormality of the mitochondrion 0.3397040410455638 1.357611454499546 0.1745870063930097 1.0 0.4272733300725502 86 Q9Y2R0,Q9H845,P13073,P21912,O75306,P23786,O96000,Q9Y6M9,P46976,Q7KZN9,P35637,Q9NX14,Q70HW3,Q9H0R6,Q86Y39,Q9P0J0,Q9UBX3,P40939,O43676,O43772,Q16836 21 +Abnormal right ventricle morphology 0.6688027662572951 1.3573227283210647 0.1746786886579785 1.0 0.4272733300725502 7 Q9H9C1,Q9H267 2 +Megalocornea 0.6071122326720276 1.3539901919828383 0.1757395068538478 1.0 0.4291180123830627 10 Q96EK5,Q13363,O95202,Q9Y5P6 4 +Abnormal waist to hip ratio 0.6875989076438022 1.3533906320113975 0.1759308686389626 1.0 0.4293516794190672 6 O76024,P31751 2 +Abnormal form of the vertebral bodies 0.3524314647484565 1.351349052112576 0.1765836458828205 1.0 0.4307105449576621 71 Q15125,Q32P28,O95202,Q9UBM7,Q14739,Q96L58,P16435,P25054,O75845,Q13363,Q8TAA9,P08236,P54802,Q10713,Q6NUQ1,Q9UHX1,Q96J02,Q9UM00 18 +Multiple prenatal fractures 0.6868990253892728 1.350243797939941 0.1769377934937974 1.0 0.4311057639523143 6 Q14739 1 +Metaphyseal striations 0.7196399475532305 1.3496684623468185 0.1771223528993188 1.0 0.4313212804189599 5 Q13126 1 +Abnormal ossification involving the femoral head and neck 0.6434940558313954 1.3473985751614472 0.1778518992537203 1.0 0.4326283598106759 3 Q14739 1 +Disproportionate tall stature 0.4653878478297988 1.3461681720176382 0.1782482870933084 1.0 0.4329281228914431 20 Q8NCH0,Q7LGA3,Q9NWM8,P16435,Q13363 5 +Mucosal telangiectasiae 0.6260524230120891 1.345314194168488 0.1785237916757818 1.0 0.4329281228914431 9 Q14739,P21912,Q8IZA0,P19447,P18074 5 +Poikiloderma 0.716426453320469 1.3450340937749687 0.1786142247439097 1.0 0.4329281228914431 4 O75431,P19447 2 +Cholestatic liver disease 0.7185272653653885 1.3449221538740044 0.1786503751325652 1.0 0.4329281228914431 5 Q9H9C1,Q9H267,Q9UBM7 3 +Retinopathy 0.4550311974178093 1.3434052695749863 0.1791407815102406 1.0 0.4336482348532685 22 O95202,O75306,Q13363,P01889,P51648 5 +Narrow palate 0.4187995106377175 1.342930655120108 0.1792944290640439 1.0 0.4337861981883715 31 Q9Y619,Q9NZ01,P41227,P48651,P16435,P23786,P25054,P19447,P50542,P61978,Q15233 11 +Calvarial hyperostosis 0.7158393783853276 1.3425379570952265 0.1794216317639172 1.0 0.4338600664636102 4 P22626 1 +Bowing of the legs 0.3943650659827382 1.3421034790488655 0.1795624460096656 1.0 0.4339667515839415 39 Q13126,Q32P28,Q96L58,Q7LGA3,P16435,P08236,Q9NR77,O75431 8 +Wormian bones 0.4906433986054044 1.3409189190089914 0.17994677896797 1.0 0.434459211836125 16 O75844,Q9Y487 2 +Progeroid facial appearance 0.6649298025368747 1.339262929310447 0.1804850924172707 1.0 0.4354930617036081 7 O75431 1 +Vocal cord paresis 0.7144984778299315 1.3368361465821883 0.1812761274352157 1.0 0.4369319333669431 4 P43243 1 +Fatigable weakness of respiratory muscles 0.5148771595332121 1.3356994635234043 0.181647524805729 1.0 0.4375921048460073 14 Q15165,P35637,P43243,Q92804 4 +Abnormality of the forearm 0.4044788908900388 1.3349363121734172 0.1818971918254324 1.0 0.4379584747384874 34 Q32P28,O95202,Q9UBM7,Q96L58,P48651,P16435,P98175,P25054,Q13363,P36507 10 +Viral encephalitis 0.5680819912152338 1.3344112206340364 0.1820691247166066 1.0 0.4381373896665579 2 P42224 1 +Abnormality of the liver 0.2943053852325368 1.3335573804087255 0.1823489584732305 1.0 0.4385756300256477 255 Q9HC07,P36551,Q9H9C1,P21912,O75306,O15118,P23786,P25054,O96000,P08236,Q9Y6M9,Q01844,Q13546,P11166,Q96A33,Q14108,Q15067,P21964,P55263,Q13363,P09601,P54802,Q10713,O75431,O14936,Q8N511,Q96EY8,P53634,O95202,Q86Y39,P22626,P28070,Q6NUQ1,Q96J02,P40939,P04062,P16930,P31751,O43676,Q9BT22,Q9NVI7,Q9UBM7,Q14739,Q9NZJ7,O43772,P06737,P07602,O43681,Q16836,O75381,Q9H267 51 +2 3 toe syndactyly 0.4492686617601461 1.331979192045857 0.1828670261780043 1.0 0.4389447958417937 23 Q15125,P37268,Q9UBM7,O43924,Q9UHX1 5 +Emg neuropathic changes 0.4534704146949515 1.331430751331432 0.1830473165589252 1.0 0.4389447958417937 22 O14773,Q8TB36,Q16637,P22626,Q9NZJ7,Q9NR77,P07602,O43681,O60313 9 +Abnormal gallbladder morphology 0.4342699645339096 1.3314141173092635 0.1830527867630027 1.0 0.4389447958417937 27 Q96A33,P78347,P21964,P53004,Q9NZJ7,O75845,P07602,O43681,P04062 9 +Glomerulopathy 0.6232565096332536 1.331233232686334 0.1831122796447108 1.0 0.4389447958417937 9 P01889,O60488,Q14108 3 +Microcornea 0.4411417759913045 1.3293626757660424 0.1837283455333609 1.0 0.4397721678686527 25 Q15125,Q8NCH0,Q9NWM8 3 +Abnormal middle phalanx morphology of the hand 0.6817420566325709 1.3270474076379433 0.1844930009400034 1.0 0.4413670512893045 6 Q8IWS0,P48651,Q9UHX1,Q15233 4 +Choanal stenosis 0.7118644467180377 1.3256335749325672 0.1849610994136703 1.0 0.4422511529933684 4 P16435 1 +Rimmed vacuoles 0.5009383413466755 1.3246885863319275 0.1852744603242719 1.0 0.4427645249921899 15 O14979,P22626,Q9Y5L0,P02545,P43243,P09651,P50402,P31483 8 +Abnormality of finger 0.3035483998209004 1.3196348328165557 0.1869569672315922 1.0 0.4463100366677586 222 Q8IWS0,P13073,Q8NCH0,P98175,P23786,P25054,O75845,O43924,Q96EK5,Q86XL3,Q9UHX1,Q15067,Q06136,P21964,O60488,P16435,Q13363,O76024,P42892,P55795,Q10713,O14936,O75431,P38435,Q86TI2,Q9UM00,P49366,Q15125,Q8TD16,P53634,O95202,Q8NBU5,Q96L58,Q7LGA3,P48651,Q92917,P28070,P50542,Q05086,Q8NFH4,Q9UBM7,Q14739,O75844,P62266,P78347,Q8N0X7,Q9H6K4,Q15233 48 +Paresthesia 0.4430825171508242 1.318977822840922 0.1871765267322367 1.0 0.4463593262350045 24 P11166,Q9H6K4,P54802,Q9NR77,P01889,P05067 6 +Abnormal oral mucosa morphology 0.3749416211694165 1.3147658461145024 0.1885886092031563 1.0 0.4494501249830341 50 Q14108,Q15392,Q9UM00,Q9UBM7,Q14739,P08236,P01889,O75431,P04062,Q13546 10 +Abnormality of mouth size 0.3295222199891737 1.313678197845588 0.1889545208911205 1.0 0.449682646327685 96 P11166,Q15392,Q9UBM7,O75844,Q8NCH0,P21964,Q7LGA3,P48651,P16435,P25054,Q01105,P55795,O75431,P04062,Q9Y487,Q05086,Q15233,Q9UM00 18 +Premature rupture of membranes 0.678706220411661 1.313384845514936 0.1890533014191913 1.0 0.449682646327685 6 Q9Y487 1 +Abnormal saccadic eye movements 0.4653769075087283 1.3131973148820373 0.1891164685526249 1.0 0.449682646327685 19 Q10713,P04062,O75306,Q8IV08 4 +Bifid scrotum 0.6786283966075604 1.3130345409894146 0.1891713093285805 1.0 0.449682646327685 6 P16435,Q9UBM7 2 +Abnormality of the spleen 0.3219202660494332 1.3067448696234294 0.1912993743570368 1.0 0.4540198794893608 105 P36551,O15118,P08236,P01889,Q13546,P11166,Q96A33,Q14108,Q15392,P21964,Q13363,P54802,Q10713,O14936,O95202,P28070,Q6NUQ1,Q96J02,P04062,P16930,Q14739,Q9NZJ7,P07602 23 +Proximal muscle weakness 0.3708651634444876 1.3010572995499514 0.1932388422950077 1.0 0.4571723374907722 56 P36551,Q8TD16,Q13126,Q8TB36,P35637,Q16637,Q99720,P22626,Q9BUK6,P21912,P07196,P09651,O60313,Q9Y5P6,P50402 15 +Neurodegeneration 0.4267276983099465 1.300359379849512 0.1934778251045417 1.0 0.4574965643146381 28 Q13057,P35637,Q15165,P08236,P43243,Q92804,P09651 7 +Lipodystrophy 0.4089701208743213 1.2966953120603388 0.194736042992494 1.0 0.4599870320791122 32 O75431,Q9Y487,P28070,P31751 4 +Prominent nasolabial fold 0.7065844185718749 1.2939432137188738 0.1956850363487747 1.0 0.461015455713019 5 Q9Y487 1 +Abnormality of the nasolabial region 0.7065844185718749 1.2939432137188738 0.1956850363487747 1.0 0.461015455713019 5 Q9Y487 1 +Abnormality of the tarsal bones 0.4531971151205484 1.2908637986312346 0.1967509104055587 1.0 0.4620113040678575 21 Q15125,Q14739,O75844,P16435,P98175,P40939,Q9UHX1,Q99567 8 +Hypertrophic cardiomyopathy 0.3263053011707398 1.2907257761322055 0.1967987833142868 1.0 0.4620113040678575 98 Q9H845,P21912,O75306,O96000,Q9Y6M9,Q7KZN9,P01889,Q9NX14,Q9H0R6,Q9H061,P54802,P36507,Q86Y39,Q96IX5,Q99797,Q9P0J0,Q5JTZ9,P40939,O60313,P16930,O43676,Q9NVI7,Q13423,P06737,Q16836,P50402 26 +Abnormal location of ears 0.3060295746405952 1.2902314016737044 0.1969703263896083 1.0 0.4620113040678575 198 Q9HC07,P37268,Q8NCH0,Q9H9C1,P98175,P23786,O43924,Q96EK5,Q9Y487,Q9UHX1,Q15392,Q15067,P21964,P16435,Q13363,P42892,Q10713,P36507,Q9UM00,P49366,Q15125,O95202,Q16625,Q96L58,Q7LGA3,Q92917,Q96J02,P50542,P04062,Q13555,Q9UBM7,Q14739,O75844,P62266,P78347,Q8N0X7,O75381,Q9H267 38 +Abnormality of metacarpal epiphyses 0.7056028333729064 1.289750854863196 0.1971371763123768 1.0 0.4620113040678575 5 Q13363,P16435 2 +Myopia 0.3346624134782444 1.2872641252116472 0.198002243151651 1.0 0.4635545473472143 86 Q8NCH0,P21912,P98175,P61978,Q9Y487,Q9UHX1,P51648,Q15067,Q9NX14,O60488,O14936,Q96L58,Q9NWM8,P40939,Q05086,Q13555,Q9NVI7,Q9Y5P6,Q15233 19 +Limb girdle muscular dystrophy 0.6533680677067004 1.2852897317843683 0.1986910570220819 1.0 0.4641210873367584 7 P09651,P02545,P50402,O14979 4 +Progressive visual loss 0.4692296039498081 1.284163298902416 0.1990848237800631 1.0 0.4643932895659683 17 O60313,P50897,O75306,O75503 4 +Coloboma 0.3901274637803202 1.283593549071397 0.1992842080811903 1.0 0.4646168965550037 38 O14936,O95202,Q9UBM7,Q13363,Q9Y5P6,O43924,Q10713,Q96EK5,P61978,Q9UHX1 10 +Micropenis 0.3718556997047357 1.2808920519348708 0.2002315849140832 1.0 0.4663320698781636 50 Q8IWS0,O95470,Q9NVI7,O75312,Q9UBM7,P16435,P48449,P42892,Q10713,P46977,O14936,P51809,Q9Y5P6 13 +Abnormal metabolic brain imaging by mrs 0.5056600391679779 1.2776888609349764 0.201359154360706 1.0 0.4679957973955716 14 P07602,Q9NZJ7,O75306 3 +Abnormality of subcutaneous fat tissue 0.5054146611662905 1.276142342540882 0.2019052059566126 1.0 0.4683104094312407 14 O75431,Q9Y487 2 +Insulin resistant diabetes mellitus 0.6513664969023913 1.2759381956460956 0.201977367630435 1.0 0.4683104094312407 7 O75431,P31751 2 +Shield chest 0.6282213674729367 1.2754710859388172 0.2021425519001805 1.0 0.4683104094312407 3 P04066 1 +Episodic ataxia 0.6999043645310258 1.2747398503836078 0.2024013368296593 1.0 0.4683104094312407 4 O14936 1 +Decreased circulating copper concentration 0.627975100695716 1.274310849291404 0.2025532730277477 1.0 0.4683104094312407 3 Q15904,Q14746 2 +Patchy changes of bone mineral density 0.6998031888262211 1.274309175659361 0.2025538659285259 1.0 0.4683104094312407 4 Q13126 1 +Arrhinencephaly 0.6117653493157587 1.2732871356228026 0.2029161699684123 1.0 0.4683104094312407 9 Q8TAA9 1 +Abnormality of the musculature of the lower limbs 0.4555188382405399 1.2732419165896545 0.20293221060768 1.0 0.4683104094312407 20 O14979,P50570,P07196,P02545,Q9NRG9,Q9NR77,P43243,O60231,Q9Y5P6,P50402 10 +Meningocele 0.6308610171381528 1.2704148105877264 0.2039369103510599 1.0 0.470091861148206 8 P21964,Q8TAA9,Q9Y5P6,Q10713 4 +Abnormal mitochondria in muscle tissue 0.4633767597356842 1.2693305487760898 0.2043231951979192 1.0 0.4704989738574968 18 O96000,Q86Y39,O75306,O43676 4 +Abnormal lung development 0.3831006855622614 1.266183584238764 0.2054473632551106 1.0 0.4717126659538734 41 O95202,Q9UBM7,Q14739,P21964,Q96L58,O75844,P98175,Q92917,P02545,Q8TAA9,O96000,Q13363,Q5JTZ9,Q9UHX1,Q99567 15 +Proptosis 0.3866919384117964 1.2660774372232788 0.2054853596196173 1.0 0.4717126659538734 39 Q32P28,O95202,Q9UBM7,O75844,Q96L58,P16435,P25054,Q13363,P61978,O75431 10 +Periventricular cysts 0.7000044286349653 1.2658349236542794 0.2055721888904926 1.0 0.4717126659538734 5 Q13363 1 +Supernumerary nipple 0.6299094724381322 1.265796352070326 0.2055860014718753 1.0 0.4717126659538734 8 P61978,Q7LGA3,Q15233 3 +Temperature instability 0.6674122747988795 1.2625199013391484 0.2067617697322823 1.0 0.4741680237907425 6 Q9NZJ7 1 +Genu valgum 0.4326187887171446 1.2603611991554071 0.207539092067738 1.0 0.4752221659183716 25 O75312,P78347,Q96L58,Q7LGA3,Q8N0X7,P08236,Q9NR77,P36507,O75431 9 +Resting tremor 0.4909806543977107 1.2598002468000584 0.2077414307452305 1.0 0.475442907284342 15 P07602,P04062,Q9NZJ7 3 +Short nail 0.6979560880374647 1.257082794491712 0.2087236566873538 1.0 0.477447385939268 5 O75844,Q9Y487 2 +Abnormal renal morphology 0.30301613275978 1.2550061851154288 0.2094765146685568 1.0 0.4787485857604933 208 Q8NCH0,Q9H9C1,P21912,O75306,P98175,P23786,P25054,O75845,Q8TAA9,P35606,O43924,P01889,P61978,Q02978,Q86XL3,Q9UHX1,Q14108,Q15392,O95470,P21964,O60488,P16435,O76024,Q10713,P36507,O14936,O75431,Q15125,Q7LGA3,P16930,Q8N1F7,Q8NFH4,O75312,Q9UBM7,Q8N0X7,O75381,Q9H267 37 +Abnormal spermatogenesis 0.6468703803314935 1.2549253987914253 0.2095058427882372 1.0 0.4787485857604933 7 P04062,P51809,P16435 3 +Acute phase response 0.4612472073622988 1.2541213409179124 0.2097979046013556 1.0 0.478928278662708 18 P36551,P21912,P41440,P28070,Q02978 5 +Generalized joint laxity 0.5874349618380504 1.2506551095277445 0.2110603349959736 1.0 0.4801278170341805 10 Q8NCH0,Q9Y487,Q9BUK6 3 +Narrow mouth 0.3663341945471097 1.2494510277724735 0.2115001546962065 1.0 0.4801278170341805 56 Q15392,P21964,Q8NCH0,Q7LGA3,O75844,P16435,O75431,P04062,Q9Y487,Q15233 10 +Aplasia hypoplasia involving the pelvis 0.5144328726338446 1.2469922099142705 0.2124003539672094 1.0 0.4811977731473175 13 Q13363,Q96L58,O95202,O75431 4 +Chronic pulmonary obstruction 0.6636241596423476 1.2454492807359667 0.2129666480826268 1.0 0.4822372939429008 6 P21964 1 +Turricephaly 0.6253718844572855 1.243766244885517 0.2135856070401569 1.0 0.483248752405183 8 P21964,P16435 2 +Abnormal cortical gyration 0.318002566827144 1.243125847596967 0.2138214623136143 1.0 0.4832646908706299 109 P37268,Q15392,Q96N66,Q9H9C1,Q9BSJ2,P23786,P35606,Q01105,Q10713,O14936,Q9Y487,O75381,Q86XL3,Q9H267 14 +Abnormal retinal morphology 0.3042517677220331 1.2430454477416626 0.2138510864681531 1.0 0.4832646908706299 174 Q9Y619,P50897,Q96CU9,Q8NCH0,P21912,P11802,O75306,P25054,O43924,P40855,Q7KZN9,P01889,Q9Y487,Q02978,Q9UHX1,P51648,O14773,Q15067,Q9NX14,P21964,Q13432,Q13363,O76024,Q10713,O14936,P38435,O75503,Q9UM00,O95202,P50570,Q7LGA3,Q9P0J0,P40939,P50542,P04062,O60313,Q9BUK6,O75312,P78347,Q9NZJ7,Q96S66,P07602,Q16836,O75381,Q9Y5P6 45 +Abnormal sella turcica morphology 0.6627695825930826 1.2415977629741513 0.2143850075581421 1.0 0.4834218845486284 6 O75431 1 +Abnormal urine alpha ketoglutarate concentration 0.6627455216558789 1.2414893198072756 0.2144250411818289 1.0 0.4834218845486284 6 P00367 1 +Abnormality of earlobe 0.4512207896945739 1.2413967520612998 0.2144592183904454 1.0 0.4834218845486284 20 Q8IWS0,Q15392,P21964,Q7LGA3,P16435,P98175 6 +Open mouth 0.4372313071731827 1.2376733059940446 0.2158372209290002 1.0 0.4857961121009795 23 P61978,P04062,Q86XL3,Q15233 4 +Hyperreflexia 0.3030788382571235 1.2363944753166245 0.2163119687055625 1.0 0.4864398696320625 200 Q9Y619,Q96CU9,P13073,P21912,Q13409,O75306,O75027,P35606,Q9NR77,Q7KZN9,P01889,Q86XL3,P11166,O14773,P35637,Q15067,O14949,O60488,Q10713,O14936,O75503,Q8TD16,O75298,Q9HCC0,Q96N66,Q99720,Q8NBU5,Q96IX5,Q16625,Q9P0J0,P50542,P04062,O60313,Q05086,Q14739,Q9H0B6,Q5JRX3,Q9NZJ7,P78347,Q9Y320,Q9BSJ2,Q8N0X7,Q9H6K4,P43243,P07602,O43681,O75381,Q9Y5P6,Q15233 49 +Abnormality of fundus pigmentation 0.690825410230834 1.2360889573085685 0.2164254990986842 1.0 0.4864398696320625 4 P38435,P25054 2 +Muscle spasm 0.3677117710786327 1.2353326241649116 0.2167067367443611 1.0 0.4864398696320625 49 P40939,P35637,Q16637,Q15165,P23786,P07196,Q9H6K4,Q9NR77,P43243,Q92804,P09651,P04062,P06737,Q9Y5P6 14 +Hyperlipidemia 0.4226961126763685 1.2347422994543495 0.2169264278800733 1.0 0.4864398696320625 27 O75844,P23786,P28070,P06737,O75431,P31751 6 +Hypopigmentation of the fundus 0.6193154477718623 1.2335114676673749 0.2173850009137969 1.0 0.4864398696320625 3 P38435 1 +Abnormality of abdominal situs 0.6901172488549336 1.233073997564499 0.2175481576868629 1.0 0.4864398696320625 4 Q13363 1 +Hypoplastic pubic rami 0.6901172488549336 1.233073997564499 0.2175481576868629 1.0 0.4864398696320625 4 Q13363 1 +Aplasia hypoplasia of the pubic bone 0.6901172488549336 1.233073997564499 0.2175481576868629 1.0 0.4864398696320625 4 Q13363 1 +Rib segmentation abnormalities 0.6901172488549336 1.233073997564499 0.2175481576868629 1.0 0.4864398696320625 4 Q13363 1 +Abnormal femoral neck morphology 0.4187494335994882 1.2325855221490425 0.2177304411905647 1.0 0.4864398696320625 28 O75844,O75431,Q96A33,Q9Y487 4 +Vertebral wedging 0.5486822840410035 1.2320370015052908 0.217935262522297 1.0 0.4866136607960541 2 Q96AY3 1 +Myopathy 0.3331823881582065 1.2308938819369313 0.2183625561270794 1.0 0.4870935858639392 81 Q9H845,Q8NCH0,P21912,O75306,P23786,P07196,P46976,O76024,P09651,Q86Y39,P22626,Q9NWM8,P40939,O60313,O43676,Q13126,Q9BUK6,O14979,P42167,Q9Y5P6,P50402,P31483 22 +Abnormal libido 0.5483162518301689 1.2301056549229177 0.2186575427348229 1.0 0.4874256164758946 2 O00170 1 +Periventricular white matter hyperintensities 0.6031742877031114 1.2299032649601245 0.2187333314577655 1.0 0.4874256164758946 9 P07602,O43681,Q9NZJ7,O75503 4 +Abnormal oral physiology 0.3671882764141279 1.2295972717296684 0.2188479521979836 1.0 0.487439012141216 49 P35637,Q14739,Q15165,O60488,Q8N0X7,Q9NR77,P55795,Q92804,P01889,P43243,Q05086,Q15233 12 +Dry skin 0.4182318682676056 1.228181348530627 0.2193788986946085 1.0 0.4883792149510929 28 P37268,Q06136,P04066,P11802,O75352,P19447,P36507,P18074,P00813,P51648 10 +Abnormality of retinal pigmentation 0.3495126856201674 1.22693484905784 0.2198470791065445 1.0 0.4889364177552884 67 Q96CU9,P21912,O75306,P25054,P40855,Q7KZN9,P51648,Q15067,Q9NX14,Q13432,P02545,O76024,Q9P0J0,P50542,P40939,Q9BUK6,Q96S66,P19447,P53701,Q16836,O75381,Q9Y5P6 22 +Pneumothorax 0.6593176790160615 1.2260388821981387 0.2201840434347723 1.0 0.4892009836313161 6 Q8NCH0 1 +Abnormality of the palm 0.3206961349076737 1.2196158108168953 0.2226105498912818 1.0 0.4923982986259599 99 Q9Y619,Q8NCH0,P21912,P98175,P25054,P40855,P61978,Q9Y487,P16615,Q99567,Q9UHX1,Q06136,P16435,P09493,P02545,Q13363,P57740,P36507,O75431,O95453,P53634,O95202,P41227,P48651,Q96J02,P50542,Q13555,P62266,Q14739,P42167,O75381 31 +Joint contracture of the hand 0.3817971408202104 1.2174268301351776 0.2234418600096788 1.0 0.4937504026210923 39 Q9Y619,Q15392,O75844,P41227,P16435,P07196,Q92917,P02545,Q8IZA0,P42892,Q9NR77,P57740,P27635,P50542,Q99567 15 +Chronic hepatic failure 0.6853635954285207 1.2128360960624482 0.2251924918414407 1.0 0.4968849082519105 4 Q10713 1 +Abnormal vascular physiology 0.3777060229082386 1.2114380159997369 0.2257275769174818 1.0 0.4974841663347514 41 Q14108,Q14739,O75844,Q9NWM8,O96000,P05067,P04062 7 +Dental crowding 0.442660229741337 1.211257781929229 0.2257966236238611 1.0 0.4974841663347514 21 Q96A33,Q9UBM7,O75844,Q01105,O75431 5 +Increased hepatic glycogen content 0.6842257800701205 1.2079923145149989 0.2270502185768292 1.0 0.499118054226935 4 P31751 1 +Aplasia hypoplasia involving bones of the thorax 0.4194845767742068 1.2078376845583592 0.2271097029838207 1.0 0.499118054226935 27 Q9Y619,Q14739,O75844,Q96L58,P48651,P16435,P98175,P02545,Q8TAA9,O75431,Q9UHX1 11 +Abnormal esophagus physiology 0.3024903264759224 1.207050653056044 0.2274126373669569 1.0 0.4993287262734358 181 P21912,O75306,O15118,Q9NR77,P01889,Q96A33,Q14108,P35637,Q15067,P21964,P16435,Q13363,O76024,P55795,P05067,Q86TI2,O95202,Q99720,Q8NBU5,Q96J02,P04062,O60313,Q05086,Q9UBM7,Q14739,Q9NZJ7,Q8N0X7,O15269,Q01105,P07602,Q15233 31 +Parkinsonism with favorable response to dopaminergic medication 0.5983579973492181 1.2055651056711283 0.2279852204980237 1.0 0.5000966127053423 9 P07602,Q9NZJ7 2 +Abnormal autonomic nervous system physiology 0.4075855441760995 1.2047112949504777 0.2283147741439588 1.0 0.5004965344050023 30 Q15067,Q9NZJ7,P41440,P42892,P07602,O43681,P04062 7 +Ascites 0.4286669394521505 1.203773690087092 0.2286770613482627 1.0 0.50063543967366 24 Q14108,Q14739,O15118,P08236,P04062,P16930 6 +Moderately reduced visual acuity 0.612768889940876 1.2026730268947663 0.2291028757709985 1.0 0.5006717279686967 3 O60313 1 +Inflammation of the large intestine 0.5327869373227067 1.2026326965178835 0.2291184891261632 1.0 0.5006717279686967 12 P01889,P08183 2 +Scrotal hypoplasia 0.4937403870734528 1.2024540505076489 0.2291876585986823 1.0 0.5006717279686967 14 P16435,Q9UBM7,P46977 3 +Intellectual disability progressive 0.5326776731403382 1.2020014040217075 0.2293629841140019 1.0 0.5006717279686967 12 Q15067,Q9NX14,P19447,P53701,P18074,Q05086 6 +Ankle clonus 0.5771030616665566 1.1962718963775405 0.231590472116997 1.0 0.5040968037948198 10 Q8N0X7,Q9NZJ7,P07602 3 +Adipose tissue loss 0.6155866895368931 1.1962321612672473 0.2316059735795272 1.0 0.5040968037948198 8 O75431 1 +Clonus 0.424666543385665 1.1957700952996142 0.2317862888767417 1.0 0.5042447234507109 25 O75298,P35637,Q99720,Q9NZJ7,O75027,Q8N0X7,P07602,Q9Y5P6 8 +Abnormality of the umbilical cord 0.6521475965713122 1.1937168970290448 0.2325887285671115 1.0 0.5054793387503943 6 O75844 1 +Abnormal chorioretinal morphology 0.4401724641989379 1.1924225752872275 0.23309559274028 1.0 0.5056225327300032 21 Q9Y619,P40939,Q9NX14,P41227,P40855,Q10713,P53701,P50542,O14936,O75381 10 +Abnormal choroid morphology 0.4401724641989379 1.1924225752872275 0.23309559274028 1.0 0.5056225327300032 21 Q9Y619,P40939,Q9NX14,P41227,P40855,Q10713,P53701,P50542,O14936,O75381 10 +Abnormal muscle glycogen content 0.6099609423165055 1.1894493623158156 0.2342628861421447 1.0 0.5076638498338705 3 Q9BUK6 1 +Abnormal pyramidal sign 0.3146000275429069 1.1887508959519624 0.2345377060822404 1.0 0.5080141046800652 115 P21912,O75306,O75027,P07196,P41440,Q9NR77,P01889,P51648,P11166,O14773,P35637,Q15067,O60488,O75298,Q99720,P40939,O60313,Q9NZJ7,Q8N0X7,Q9H6K4,P07602,O43681,P51572,Q9Y5P6 24 +Small earlobe 0.6794215484850976 1.187542496237255 0.2350137045332787 1.0 0.5085542458752917 4 P21964 1 +Myalgia 0.388668494640802 1.1863587844511707 0.2354806409621619 1.0 0.5089784195822036 34 P40939,Q9H845,Q9BUK6,Q14739,P21964,P23786,P25054,P43243,P01889,O60313 10 +Abnormal tissue metabolite concentration 0.4900138982650208 1.1788935029471754 0.2384405851573894 1.0 0.5137404446405971 14 P50542,Q9NZJ7,P40855,P07602,O43681,O75381 6 +Abnormal morphology of the musculature of the neck 0.503140059794063 1.178268978932615 0.2386893906820426 1.0 0.5138642148231537 13 P35637,Q99720 2 +Aplasia hypoplasia involving the femoral head and neck 0.6117174608173518 1.1774303936012005 0.2390237646595803 1.0 0.5138642148231537 8 Q96L58,O75431 2 +Bilateral tonic clonic seizure with generalized onset 0.611477659745683 1.1762650757221111 0.2394889670505153 1.0 0.5138642148231537 8 P11166,P04062,Q05086 3 +Chorioretinal coloboma 0.678778069000259 1.1751258460282377 0.2399443717010396 1.0 0.5142647278864689 5 O14936,Q10713 2 +Atrophic scars 0.6294902801342986 1.1736476434857936 0.2405361894310949 1.0 0.5152441646978366 7 Q8NCH0,Q96L58,Q9NWM8 3 +Abnormal abdomen morphology 0.3005626682582286 1.173367897963748 0.240648304836331 1.0 0.5152441646978366 190 Q9HC07,P36551,O75306,O15118,P23786,O96000,P08236,Q9Y6M9,Q01844,P01889,Q13546,P11166,Q96A33,Q14108,Q15392,Q15067,P21964,P09601,P54802,Q10713,O75431,O14936,Q96EY8,Q86Y39,P28070,Q6NUQ1,Q96J02,P40939,P04062,P16930,P31751,O43676,Q9BT22,Q14739,Q9NZJ7,O43772,P06737,P07602,O75381 39 +Neoplasm of fatty tissue 0.5726037942272264 1.1725734670712358 0.2409668946886272 1.0 0.5154716031280071 10 P21912,Q9BUK6,Q8TAA9 3 +Convex nasal ridge 0.4459157178702705 1.17158093941859 0.241365344302709 1.0 0.5160779729540534 19 O95202,O75844,P25054,Q13363,Q96J02 5 +Neonatal hypoglycemia 0.5915139598071748 1.1709672478995627 0.2416119423178608 1.0 0.5161993335600711 9 Q16836,P31751,O43772 3 +Lower limb spasticity 0.3346012459858747 1.1683686807834583 0.2426580824868618 1.0 0.517609065684903 73 Q13057,Q9Y619,Q96CU9,P21912,O75306,Q7KZN9,P11166,P35637,Q5T440,O75298,Q99720,Q9P0J0,P04062,O60313,Q9H0B6,Q9NZJ7,Q8N0X7,Q9H6K4,P07602 19 +Headache 0.3579754343744562 1.1662943003230686 0.2434954768504682 1.0 0.518863243560367 57 P11166,Q9NQZ5,P21912,P23786,P25054,Q8TAA9,P01889,P04062,O60313,Q02978,P05067,Q8N1F7 12 +Generalized abnormality of skin 0.3003356245105651 1.1660533355912397 0.2435928819477926 1.0 0.518863243560367 182 P36551,P37268,Q8NCH0,Q9H9C1,P21912,O75306,O15118,P98175,P01889,Q9Y487,Q02978,P51648,P11166,Q14108,P28288,Q9NX14,Q06136,P21964,P36507,O75431,O14936,P38435,P00813,Q15125,Q16625,Q96L58,P48651,Q9NWM8,Q8IZA0,Q6NUQ1,P04062,Q13126,Q9UBM7,Q14739,O75844,O43772,O15269,O75381,Q9H267 39 +Abnormal palmar dermatoglyphics 0.3610832949400024 1.1644075900509283 0.2442588731419783 1.0 0.5198249975125774 53 O95202,P62266,Q8NCH0,P98175,P25054,Q13363,Q96J02,P40855,P57740,P36507,P50542,P61978,Q9Y487,O75381,Q9UHX1,Q99567,O75431 17 +Cone cone rod dystrophy 0.5351390922401249 1.1606213048690064 0.2457959374633729 1.0 0.5215333668923919 2 Q6P4Q7 1 +Leukodystrophy 0.3607107711054093 1.1602252547671592 0.245957107232897 1.0 0.5215333668923919 53 Q86Y39,Q15067,P21912,Q9NZJ7,O75306,O96000,P07602,O43681,O43676 9 +Synostosis involving bones of the upper limbs 0.4232280916299774 1.160156120097344 0.2459852486883078 1.0 0.5215333668923919 24 O95202,Q96L58,P16435,P25054,Q13363,Q15233 6 +Respiratory distress 0.3645395387013885 1.1581563174087095 0.2468002509871265 1.0 0.5224714747312377 45 Q96L58,Q9NZJ7,O75306,P23786,P07602,Q96EY8 6 +Slender finger 0.3810254471824937 1.1542035615648347 0.2484167227629676 1.0 0.524162788791819 35 P53634,P21964,Q8NCH0,Q96L58,P16435,Q13363,P55795 7 +Prominent nasal bridge 0.3737530137213987 1.1535881301985886 0.2486690670242641 1.0 0.5244486714308729 40 Q15125,P13073,P21964,P42892,O43924,O14936,Q15233 7 +Skin plaque 0.6736640719049616 1.15327789221232 0.2487963413107388 1.0 0.5244706340077951 5 Q06136 1 +Exercise intolerance 0.4128956432029851 1.1525489304219716 0.2490955751397223 1.0 0.5246086068639484 27 Q9Y2R0,P23786,Q9H2D1,P40939,Q9Y5P6 5 +Aplasia hypoplasia of toe 0.4159810775422352 1.1505021393903034 0.2499371135610886 1.0 0.5251487666957705 26 Q8IWS0,O95202,P13073,Q9UBM7,Q7LGA3,P25054,Q13363,Q9UHX1 8 +Dermal atrophy 0.4125246412048182 1.149432591109818 0.2503776476647401 1.0 0.5258282090404088 27 P53634,Q15392,Q9NX14,O75844,Q8NCH0,Q96L58,Q9NWM8,P02545,P19447,P53701,O95453 11 +Hypoplasia of the frontal lobes 0.6418571849907375 1.1473334884502822 0.2512438184755754 1.0 0.5274004945361939 6 Q86XL3,Q9UBM7 2 +Decreased calvarial ossification 0.6698172680923128 1.146679033029415 0.2515142990935666 1.0 0.5274860365854045 4 O75844,O75718 2 +Calvarial skull defect 0.6237213564115912 1.1466661291328697 0.2515196342007053 1.0 0.5274860365854045 7 Q13363,Q14739 2 +Dysostosis multiplex 0.6236121804696684 1.1461555567043136 0.251730793378377 1.0 0.5276822983102083 7 P10619,P08236,P54802,P04066 4 +Supernumerary bones of the axial skeleton 0.6695045980877302 1.1453492901745663 0.2520644954913962 1.0 0.5281351334105444 4 O75431 1 +Hydrocele testis 0.6691164122865294 1.1436984503095335 0.2527487162994204 1.0 0.5283162265041812 4 Q9UBX3 1 +Tapered finger 0.3965121831900838 1.143497547755665 0.2528320722867374 1.0 0.5283162265041812 31 Q06136,P42892,P23786 3 +Equinovarus deformity 0.668854894170579 1.1425863297557028 0.2532103839595574 1.0 0.5283162265041812 4 Q9NR77 1 +Abnormal circulating aspartate family amino acid concentration 0.6042801686848958 1.1412888098578362 0.2537497572608747 1.0 0.5289878085743274 8 P16930,P55263 2 +Functional abnormality of the inner ear 0.297028290508214 1.1406997493038529 0.2539948909337157 1.0 0.5289878085743274 210 P21912,O75306,P07196,P41440,O96000,Q9Y6M9,Q9NR77,P46976,P01889,P61978,Q02978,P35637,Q15067,O95470,Q9NX14,Q9H061,P55263,Q13363,O76024,P42892,O14936,Q15125,O95202,Q86Y39,Q96L58,Q7LGA3,P48651,Q9NWM8,Q15120,P38159,P04062,O60313,O43676,Q9UBM7,O75844,P42167,Q9NZJ7,O15269,P51572,P07602,O43681,O75381,Q9Y5P6 43 +Angina pectoris 0.6684056077729017 1.1406757885707064 0.2540048655223854 1.0 0.5289878085743274 4 O75844 1 +Small placenta 0.5995378906615266 1.140395433944169 0.254121594315118 1.0 0.5289878085743274 3 O75844 1 +Short umbilical cord 0.5995378906615266 1.140395433944169 0.254121594315118 1.0 0.5289878085743274 3 O75844 1 +Abnormal nephron morphology 0.3589838001396496 1.1396445224045617 0.254434428639011 1.0 0.5291481537219098 52 Q8NFH4,Q14108,O95470,Q8N1F7,P78347,P21912,O60488,O75306,P23786,P02545,P01889,P00813,P16930,Q02978,Q14C86,O75431 16 +Hypoplasia of the musculature 0.670264378042909 1.13875811284786 0.2548040569491299 1.0 0.5296650251097509 5 Q9Y487 1 +Aplasia hypoplasia of the nails 0.3566285804934406 1.1384826585009304 0.2549189960421261 1.0 0.5296650251097509 56 O14936,Q14739,O75844,Q96L58,P23786,P25054,O75431,Q9Y487,P16615 9 +Extramedullary hematopoiesis 0.5985185125214876 1.1356015185202613 0.2561233730599268 1.0 0.5308055489369667 3 Q14739 1 +Abnormality of the anterior fontanelle 0.4036068455173 1.1351077500030906 0.2563301747667639 1.0 0.5308055489369667 29 Q15125,Q32P28,Q9Y487,O75381 4 +Abnormal renal tubule morphology 0.4480293269037244 1.135051146267902 0.2563538891309029 1.0 0.5308055489369667 17 O75306 1 +Abnormality of the supraorbital ridges 0.4325762279700105 1.13483346968343 0.2564450998140937 1.0 0.5308055489369667 21 Q8IWS0,P16435,P98175,P38159,Q9UPP1,P40855,P36507,P50542,O75381 9 +Abnormality of thalamus morphology 0.5210439176071247 1.1347404102829983 0.2564841003720055 1.0 0.5308055489369667 12 P11166,Q9Y5P6,O75306 3 +Oral cleft 0.3092485101025136 1.1347125559075388 0.256495774751031 1.0 0.5308055489369667 135 Q9Y619,Q8IWS0,Q8NCH0,P98175,Q8TAA9,O43924,Q96EK5,P61978,Q9UHX1,Q99567,Q15392,P21964,P16435,P02545,Q13363,P57740,Q10713,P36507,O14936,P46783,Q9UM00,Q15125,O95202,Q96L58,P41227,Q7LGA3,Q9NWM8,P48651,O00571,P50542,O75312,Q9UBM7,Q14739,O75844,P62266,Q9Y5P6,Q15233 37 +Abnormality of the glabella 0.6669486834343741 1.134481049615666 0.2565928183884316 1.0 0.5308055489369667 4 Q13363 1 +Aplasia hypoplasia of the lungs 0.3954946829197303 1.1343538708400065 0.256646140491636 1.0 0.5308055489369667 31 O95202,Q9UBM7,Q14739,O75844,Q96L58,P98175,Q92917,P02545,Q8TAA9,O96000,Q13363,Q5JTZ9,Q99567 13 +Abnormality of the wrist 0.4171056101027685 1.134204683659628 0.2567086998393679 1.0 0.5308055489369667 25 Q15125,O75844,Q96L58,P16435,Q9H6K4 5 +Arachnodactyly 0.3995760668498647 1.1340611338282105 0.2567689052455781 1.0 0.5308055489369667 30 P53634,P21964,Q8NCH0,Q96L58,P16435,Q13363,P55795 7 +Young adult onset 0.545818742123927 1.132883451644641 0.2572632002328447 1.0 0.5314348995994715 11 P36551,Q9NZJ7,O15118,P02545,P07602,P38435,P31483 7 +Abnormality of the musculature of the upper arm 0.6385004000843489 1.1322080097418263 0.2575469934556262 1.0 0.5314348995994715 6 P02545,P50402,O14979 3 +Proximal upper limb amyotrophy 0.6385004000843489 1.1322080097418263 0.2575469934556262 1.0 0.5314348995994715 6 P02545,P50402,O14979 3 +Abnormal thyroid hormone level 0.5296486090776018 1.131708932413764 0.2577568249309228 1.0 0.5316234514200282 2 O14654 1 +Abnormal myocardium morphology 0.3051989051701199 1.131248056634964 0.2579507002765897 1.0 0.5317789356184358 150 P50402,Q9H845,P21912,O75306,P23786,O96000,P08236,Q9Y6M9,P46976,Q7KZN9,P01889,Q14108,Q9NX14,Q9H0R6,Q9H061,O76024,P54802,P36507,P09651,Q86Y39,P22626,Q96IX5,Q99797,Q9P0J0,Q5JTZ9,P40939,P50542,P04062,P16930,O60313,O43676,Q9BT22,Q9NVI7,Q13423,P42167,O43772,P06737,Q16836,O75381,Q9Y5P6,Q15233 41 +Central nervous system cyst 0.3618172896465169 1.1291712296961762 0.2588256078725581 1.0 0.5327585197761827 45 Q15125,O95202,Q9UBM7,Q9BSJ2,P23786,Q13363,Q9Y487,Q9Y5P6 8 +Abnormal c peptide level 0.6655822168395342 1.128671914122774 0.2590362614560635 1.0 0.5327585197761827 4 Q16836 1 +Decreased number of peripheral myelinated nerve fibers 0.4820541243213063 1.1285224865471768 0.2590993257445715 1.0 0.5327585197761827 14 Q8TB36,Q9H0B6,P50570,P07196,O15269,Q9NR77 6 +Abnormal aortic valve cusp morphology 0.4358254046692275 1.1269946238407436 0.2597447540322022 1.0 0.5337611978463935 20 P37268,P78347,Q96L58,P61978,Q9UHX1 5 +Inability to walk 0.3330593318760305 1.1246199380078397 0.2607501212254106 1.0 0.5355240826041386 72 P11166,Q8TB36,P35637,Q96N66,Q99720,Q9NVI7,Q9BUK6,P21912,O14949,Q13363,Q9Y5P6,O15269,Q9NR77,P61978,O75503 15 +Decreased circulating cortisol level 0.6189606510440646 1.1244049442105413 0.2608412755286646 1.0 0.5355240826041386 7 Q13423,Q9H0R6,P16435 3 +Relative macrocephaly 0.4094810944608498 1.1238562043362843 0.2610740333194816 1.0 0.5357568639862065 27 Q15392,O75844,Q7LGA3,P48651,P25054,Q15233 6 +Thick hair 0.6359392319526325 1.120670241646246 0.2624282536502509 1.0 0.537692654728343 6 Q9Y487 1 +Skin pit 0.5184150087817465 1.1195327004857158 0.262912948415879 1.0 0.5380544060604034 12 Q13363,P16615,P61978 3 +Asymmetric growth 0.5621157867724418 1.1173153283215218 0.2638595238114014 1.0 0.5390455827458824 10 Q15125 1 +Sensory ataxia 0.6628927625820895 1.1172415022518594 0.2638910798521161 1.0 0.5390455827458824 4 Q9NR77 1 +Dysuria 0.5992718598433295 1.116954726611716 0.2640136832475024 1.0 0.5390455827458824 8 P01889,Q8N0X7 2 +Abnormality of mouth shape 0.3569323097526644 1.1167109777308988 0.2641179225619865 1.0 0.5390455827458824 52 Q15125,Q96A33,O95202,O75312,Q13363,Q10713,P61978,P04062,Q86XL3,Q15233 10 +Diffuse cerebral atrophy 0.4683792828019383 1.1119263875332095 0.2661698020423033 1.0 0.5424932205112886 15 P07602,O14936,Q9NZJ7 3 +Abnormal involuntary eye movements 0.2878339573475753 1.1095044391540898 0.2672126304780222 1.0 0.5438776805375799 243 Q8IWS0,P21912,O75306,O75027,P25054,P07196,P41440,O96000,O43924,Q9NR77,Q9Y6M9,Q8IV08,P01889,Q7KZN9,P11166,O14773,P35637,Q15392,Q15067,Q9NX14,Q99707,Q9H061,Q13363,O76024,Q10713,P36507,O14936,O75503,Q15125,O95202,Q86Y39,Q99720,Q16625,Q7LGA3,Q9P0J0,Q5JTZ9,P04062,O60313,Q05086,O43676,Q9BT22,Q9NVI7,Q9UBM7,Q9H0B6,Q9NZJ7,O43772,Q9H6K4,P07602,O75381,Q9Y5P6,Q8WWV3 51 +Elevated pulmonary artery pressure 0.4409762646425157 1.1088988867432608 0.2674738041519848 1.0 0.5441624809764769 18 O75844,P04062,O96000,Q14108 4 +Insulin resistance 0.4559844822692396 1.1062609070777314 0.2686136071572238 1.0 0.5455572530716541 16 O75844,O76024,P31751,O75431 4 +Abnormality of the abdominal wall 0.3188518372498551 1.1056212823547975 0.2688904742087614 1.0 0.5455572530716541 91 Q32P28,Q9UBM7,Q14739,O75844,Q9Y487,Q8NCH0,P21964,Q9NWM8,Q8NBU5,P25054,P08236,Q10713,O14936,P16930,Q9UM00 15 +Premature skin wrinkling 0.4405029643816908 1.1055008476092438 0.2689426273330269 1.0 0.5455572530716541 18 P11166,O75844,P02545,P36507,Q9Y487,O95453 6 +Primary adrenal insufficiency 0.5159769050428515 1.105427460260649 0.2689744104332146 1.0 0.5455572530716541 12 Q13423,Q9H0R6,P16435,P40855,P50542,O75381 6 +Flattened epiphysis 0.5245241581259245 1.1047549847628186 0.2692657708431198 1.0 0.5455572530716541 2 O95831 1 +Premature osteoarthritis 0.5245241581259245 1.1047549847628186 0.2692657708431198 1.0 0.5455572530716541 2 Q96HY6 1 +Downslanted palpebral fissures 0.3092289498216013 1.1045113735383971 0.2693713726022642 1.0 0.5455572530716541 111 Q8NCH0,P25054,O75845,Q96EK5,P61978,Q9Y487,Q15392,P21964,O60488,P16435,Q13363,O14936,Q9UM00,Q15125,O95202,Q7LGA3,Q05086,Q9UBM7,O75844,Q8N0X7,Q15233 21 +Epicanthus 0.3076234919923197 1.1045030720790654 0.2693749716592659 1.0 0.5455572530716541 134 Q9Y2R0,P37268,O43924,Q9Y487,Q15392,Q15067,P21964,Q13363,P55795,Q10713,O14936,Q9UM00,Q15125,Q7LGA3,Q05086,Q9UBM7,Q8N0X7,O75381,Q15233 19 +Prominent superficial blood vessels 0.515767629913686 1.1042166986530415 0.2694991476593085 1.0 0.5455625506066651 12 O75844,Q9Y487 2 +Abnormal thoracic spine morphology 0.4103212393035649 1.1036608240953385 0.2697402956728141 1.0 0.5457619598256531 26 P50542,O75844,Q13724,O75845,P02545,Q9UPP1,P19447,P08236,Q96J02,P18074,P04062,Q9UHX1,P51648 13 +Abnormally folded helix 0.477821968554483 1.101722426759112 0.2705823639212066 1.0 0.5469658010456657 14 P23786 1 +Impairment in personality functioning 0.2972374489431637 1.1014983489782098 0.2706798226654241 1.0 0.5469658010456657 166 P36551,Q13057,P50897,P21912,O75306,Q8TAA9,Q7KZN9,P01889,Q02978,P16615,P11166,P35637,P21964,Q15165,O60488,O76024,P55795,P05067,P09651,O75503,Q9UM00,Q96N66,Q7LGA3,P49770,Q9P0J0,Q92804,P04062,Q05086,Q9BUK6,Q9NZJ7,O96008,Q8N0X7,P43243,P07602,O43681,Q15233 36 +Neck flexor weakness 0.6591053590074353 1.1011522899186243 0.2708303823185172 1.0 0.5470237425047277 4 P35637,Q99720 2 +Sclerosis of skull base 0.590390055676093 1.0974059243564311 0.2724639847847956 1.0 0.5498284009506127 3 Q14739 1 +Hyperconvex nail 0.5951657524719464 1.0970096947018433 0.2726371541558543 1.0 0.5499305833040333 8 Q13363,P48651,O95202,P42892 4 +Cutaneous cyst 0.6574199636744399 1.093995750606198 0.2739568419212306 1.0 0.551430731415326 4 Q8TAA9 1 +Short nose 0.323973952063721 1.0936694184373024 0.2740999914260487 1.0 0.551430731415326 79 Q9NVI7,Q15392,O75312,O75844,Q8NCH0,Q96L58,P16435,P25054,O75845,P38435,P42892,O14936,P04062,Q9Y487,Q9UHX1,Q9UM00 16 +Abnormal midbrain morphology 0.611970621698051 1.0917341356014985 0.2749499765550469 1.0 0.5528303309513397 7 P04062,O43924 2 +Abnormality of blood circulation 0.3492894501117808 1.091483498104722 0.2750601891743185 1.0 0.5528303309513397 59 Q14739,P21964,O75844,P21912,P16930,P23786,P25054,O76024,P01889,P04062,Q9Y487,Q02978,P05067 13 +Rigidity 0.3554143118755998 1.0890519096134252 0.2761309951408774 1.0 0.5545490611856847 48 Q15392,Q8NBU5,O43681,Q9NZJ7,Q9H6K4,P07602,O14936,P04062 8 +Limb girdle muscle atrophy 0.5752751982921889 1.0888702990484456 0.2762110854727373 1.0 0.5545490611856847 9 P09651,P50402,O14979 3 +Abnormality of the kidney 0.2880938222546148 1.0871824425210368 0.2769561886139249 1.0 0.5553973970059406 283 P36551,Q8NCH0,Q9H9C1,P21912,O75306,P23786,P25054,Q8TAA9,P35606,O43924,O96000,Q9Y6M9,P01889,P61978,Q02978,Q86XL3,Q14108,Q15392,O95470,P21964,P16435,Q13363,O76024,P09601,Q10713,O75431,O14936,Q9UM00,Q15125,O95202,Q86Y39,Q96L58,Q7LGA3,P04062,P16930,O43676,Q8N1F7,Q8NFH4,Q9BT22,Q9UBM7,O43772,Q8N0X7,P06737,P51809,O75381,Q9H267 46 +Temporal pattern 0.6580302156221097 1.086551097150413 0.277235247274878 1.0 0.5557087046760395 5 P04062,Q9NR77 2 +Abnormality of the calvaria 0.2945192971900067 1.0845018291386286 0.2781423564101448 1.0 0.5567809525284255 208 Q32P28,Q8IWS0,P13073,Q8NCH0,P98175,P25054,O75845,O43924,P61978,Q9Y487,Q96A33,Q15392,Q15067,P21964,P55263,P16435,Q13363,P54802,Q10713,P36507,P09651,O14936,O75431,Q9UM00,Q15125,O95202,P22626,Q96L58,P48651,Q96J02,P04062,Q05086,Q9BT22,Q9NVI7,Q9UBM7,Q14739,O75844,Q01105,O75381,Q15233 40 +Abnormal exteroceptive sensation 0.3548856604517528 1.0832767027224766 0.2786856229161043 1.0 0.5572592539842932 48 P11166,Q8NCH0,Q9NZJ7,Q9H6K4,O15269,Q9NR77,P54802,P01889,P61978,P07602,P05067 11 +Abnormality of facial adipose tissue 0.6547925187696876 1.082843350734176 0.2788779599930309 1.0 0.5572592539842932 4 O75844 1 +Abscess 0.6272677062094203 1.0816298305317693 0.2794170439439547 1.0 0.557603854045549 6 Q8TAA9,Q13546 2 +Fatigue 0.3347344766126968 1.0813366577657872 0.2795473867206963 1.0 0.557603854045549 69 P35637,Q70HW3,Q14739,Q15165,P21912,Q13423,Q9NZJ7,P06737,P07602,Q92804,P01889,P04062,O60313,Q02978 14 +Thin skin 0.4172575035686991 1.0803674963775751 0.2799785639441992 1.0 0.5582158129638232 23 O75844,O75431,Q96L58,Q13126 4 +Brain imaging abnormality 0.3972623475587484 1.079985575302711 0.2801486036462119 1.0 0.5582672566544702 29 P11166,P21912,Q9NZJ7,O75306,P07602,Q05086 6 +Proportionate short stature 0.389280728052694 1.078463364856547 0.2808270224033666 1.0 0.5586963984893694 31 Q15392,Q14739,Q96L58,P21912,P48651,P40939,Q16836,Q13555 8 +Renal tubular acidosis 0.5359175804482574 1.0784296974702992 0.2808420398823568 1.0 0.5586963984893694 11 Q9H9C1,P16930,O75306 3 +Pigmentary retinopathy 0.3583368922297907 1.0703864776235277 0.2844453834225608 1.0 0.5641143971720959 44 Q15067,Q9NX14,P50542,Q9BUK6,P21912,O75306,Q9P0J0,Q96S66,O76024,Q7KZN9,P40939,Q16836,Q9Y5P6 13 +Anteriorly placed anus 0.5530497057017718 1.0695566059114463 0.284818936546229 1.0 0.5646057364043621 10 P48651,P16435,Q9NX14 3 +Cerebral hemorrhage 0.5526067015726936 1.067223657151408 0.2858708522404538 1.0 0.5660816693246439 10 P05067,Q02978,P23786 3 +Multiple lipomas 0.6240403364702114 1.0671117712244618 0.2859213669728917 1.0 0.5660816693246439 6 Q8TAA9,Q9BUK6 2 +Abnormality of the amniotic fluid 0.3302763853876367 1.066110025978921 0.2863739079209331 1.0 0.5660816693246439 71 P49366,Q15125,Q9BT22,Q9NVI7,Q9UBM7,Q70HW3,P21964,Q96L58,Q7LGA3,Q14739,O75844,P16435,P23786,Q9Y5P6,P40939,P04062,Q9UHX1,Q9UM00 18 +Ventricular arrhythmia 0.375924208134349 1.065959235851761 0.2864420696134675 1.0 0.5660816693246439 34 P36551,P21912,O75306,O43772,P23786,P42892,P46976,P50402 8 +Functional abnormality of the middle ear 0.3250334136819591 1.0659496430897244 0.2864464062023766 1.0 0.5660816693246439 74 P21964,Q96L58,P21912,Q7LGA3,Q9NWM8,O75844,P16435,Q13363,O43924,P01889,P61978,Q02978 12 +Scarring 0.3875437313436445 1.0628276777243353 0.2878601054086558 1.0 0.567059687898517 31 P36551,Q15125,Q8NCH0,Q96L58,Q9NWM8,P25054 6 +Acne 0.5330323124667975 1.062564894232557 0.2879793143088109 1.0 0.567059687898517 11 P21964 1 +Hypoglycemic coma 0.57000702900803 1.062252351000675 0.2881211395223417 1.0 0.567059687898517 9 P00367,P40939,Q16836,P31751 4 +Preaxial hand polydactyly 0.6056185515679795 1.0620680324828624 0.2882048012692775 1.0 0.567059687898517 7 Q13363,Q9UPP1,O95202,Q9UHX1 4 +Polymicrogyria 0.3377004902975442 1.0612796120748986 0.2885628483393572 1.0 0.5675153651827498 66 Q8TD16,Q9NZ01,P37268,Q15392,Q96N66,Q16625,P50542,P23786,Q01105,Q10713,Q96EK5,Q9Y320,Q9Y487,O75381,Q9Y5P6 15 +Variable expressivity 0.3331058156363505 1.0606163037233352 0.2888643101466068 1.0 0.5678594060175084 69 P07196,P46976,Q9NR77,P11166,O95470,Q70HW3,Q9H061,P02545,P57740,Q5T440,O95453,O00429,Q8TD16,Q15125,Q6P4A7,P41227,Q9NQT5,Q9NZJ7,P43243,P07602,Q9Y5P6 21 +Hepatic failure 0.3590996086830596 1.0581360351929885 0.2899934278984186 1.0 0.5695081136120392 43 Q9Y619,P40939,P28288,Q9H845,P50542,O15118,P23786,O75845,O43772,Q16836,Q6NUQ1,Q10713,Q96J02,P01889,P04062,P16930,O75381 17 +Aplasia hypoplasia involving the skeleton 0.2859662410897857 1.0548448185267243 0.2914963029769322 1.0 0.5700372147104452 241 Q13057,Q9Y619,Q32P28,Q8IWS0,P37268,P13073,Q8NCH0,P98175,P25054,O75845,Q8TAA9,O43924,P40855,P08236,Q96EK5,Q86XL3,Q99567,Q9UHX1,O75718,Q96A33,Q15392,Q9NX14,P21964,O60488,P16435,P02545,Q13363,P57740,P55795,O75431,O14936,P38435,P46783,P00813,Q9UM00,Q15125,Q8TD16,O95202,Q16625,Q96L58,Q7LGA3,P48651,Q92917,Q6NUQ1,P50542,P04062,Q13555,Q9BT22,Q9NVI7,Q9BUK6,Q9UBM7,Q14739,O75844,P78347,Q8N0X7,Q14671,O75381,Q9H267 58 +Gait ataxia 0.3422111384362507 1.0503158452947596 0.2935729224458474 1.0 0.5728501199725927 62 O14773,Q14108,Q9NVI7,Q9NZJ7,O15118,P07196,P41440,Q13363,Q9NR77,Q8IV08,Q10713,P07602,O43681,Q05086 14 +Cyanosis 0.4324244941990443 1.0474748039242008 0.2948806469992702 1.0 0.5735309654429315 18 P11166,O75844,O43772,P98175,P02545,P04066 6 +Abnormal venous morphology 0.4250963282722509 1.0470598629072696 0.2950719695204387 1.0 0.5735309654429315 20 P21964,P04062,P48651,Q9Y487 4 +Abnormality of the nail 0.308366389839938 1.0458104379837831 0.2956485610269024 1.0 0.5744029185665533 100 Q15125,P53634,O14936,O95202,Q14739,Q06136,O75844,Q96L58,P48651,P23786,P25054,Q13363,P42892,O75431,Q9Y487,P16615 16 +Exercise induced muscle cramps 0.6190468530228241 1.0446652519333115 0.2961777099807143 1.0 0.574684635708364 6 P23786 1 +Tracheal stenosis 0.6453740917888366 1.0429158269844951 0.2969872787528937 1.0 0.5757576272323919 4 Q15125 1 +Dilated fourth ventricle 0.373420342951367 1.0422631744277149 0.2972896807144076 1.0 0.5760950289491631 34 Q15125,Q9UBM7,P23786,Q10713,O14936,Q9Y487 6 +Fluctuations in consciousness 0.6472430093274862 1.0406028218906371 0.2980599210134034 1.0 0.576904275013726 5 O75306 1 +Short upper lip 0.6448110605324795 1.0405317577614306 0.2980929175037501 1.0 0.576904275013726 4 Q13363 1 +Anarthria 0.6170898510725973 1.0358743119585767 0.3002607832008568 1.0 0.5805990499808036 6 Q99720 1 +Acquired abnormal hair pattern 0.6165013318493837 1.033231389180282 0.3014956267550088 1.0 0.5826986980756826 6 O75844,P25054 2 +Short digit 0.3047404124495149 1.0325012021235251 0.3018373847945463 1.0 0.5826986980756826 113 Q8IWS0,P13073,P21912,P25054,O43924,Q9UHX1,P11166,Q06136,O60488,P16435,Q13363,O14936,P38435,O95202,Q7LGA3,P48651,Q13555,Q9UBM7,Q14739,O75844,Q8N0X7,P48449 22 +Pulmonary infiltrates 0.61631115977775 1.0323774387520637 0.3018953367677917 1.0 0.5826986980756826 6 P04062 1 +Corneal ulceration 0.6452589168042873 1.032162914817198 0.3019958047513453 1.0 0.5826986980756826 5 O75844,Q96EK5 2 +Pituitary prolactin cell adenoma 0.5102489019033775 1.0298855846739503 0.3030637184451286 1.0 0.5830047014067076 2 O00170 1 +Elevated circulating growth hormone concentration 0.5102489019033775 1.0298855846739503 0.3030637184451286 1.0 0.5830047014067076 2 O00170 1 +Congenital craniofacial dysostosis 0.5102489019033748 1.0298855846739372 0.3030637184451348 1.0 0.5830047014067076 2 Q6NUK1 1 +Hepatocellular adenoma 0.5102489019033718 1.029885584673921 0.3030637184451423 1.0 0.5830047014067076 2 Q9UKG1 1 +Hyperphosphatemia 0.5102489019033689 1.029885584673906 0.3030637184451494 1.0 0.5830047014067076 2 Q15813 1 +Abnormal thyroid stimulating hormone level 0.5102489019033672 1.0298855846738977 0.3030637184451534 1.0 0.5830047014067076 2 O14654 1 +Heterogeneous 0.3657122229329429 1.029587014084108 0.3032039137676592 1.0 0.5830244922833139 37 P53634,Q8TB36,Q9HCC0,P40939,Q9BQE5,P21964,O75844,P07196,P25054,P00367,Q9NR77,P01889,Q16836,P05067 14 +Abnormal b cell morphology 0.563381802039303 1.0288024828184796 0.3035724998031841 1.0 0.5832579562031585 9 P17812,Q13546,Q13432 3 +Abnormal skin morphology of the palm 0.3167735953525811 1.0287753632289294 0.3035852463659934 1.0 0.5832579562031585 85 Q8NCH0,P21912,P98175,P25054,P40855,P61978,Q9Y487,P16615,Q99567,Q9UHX1,Q06136,P09493,P02545,Q13363,P57740,P36507,O75431,O95453,P53634,O95202,P41227,Q96J02,P50542,P62266,Q14739,P42167,O75381 27 +Corticospinal tract hypoplasia 0.5098828696925402 1.027971019983362 0.3039634599369969 1.0 0.5836189759251245 2 Q13045 1 +Abnormal renal physiology 0.3025138181499052 1.0277611908903874 0.3040621759960091 1.0 0.5836189759251245 137 P36551,Q8NCH0,Q9H9C1,P21912,O75306,P23786,Q8TAA9,O96000,Q9Y6M9,P01889,Q02978,Q14108,O95470,O76024,P09601,Q10713,Q86Y39,P04062,P16930,O43676,Q8N1F7,Q8NFH4,O43772,P51809,Q9H267 25 +Urinary glycosaminoglycan excretion 0.6151233816793351 1.0270446701447018 0.3043994303680415 1.0 0.5837857198654153 6 P08236,P54802,P04066 3 +Progressive cerebellar ataxia 0.365429014432779 1.0268091668767687 0.3045103320420983 1.0 0.5837857198654153 37 Q9Y619,O14773,P35637,Q9BUK6,O75306,Q9P0J0,P41440,O76024,Q7KZN9,Q9Y487 10 +Renal dysplasia 0.5628164157391606 1.0259495393167215 0.3049153699192248 1.0 0.5840632437889377 9 O75306 1 +Menorrhagia 0.5091508052708715 1.0241427848143425 0.3057678384199747 1.0 0.5854462708314191 2 P35579 1 +Muscle hypertrophy of the lower extremities 0.5964405739929047 1.0192599364779182 0.3080795786352377 1.0 0.5889238629560677 7 P50570,P02545,Q9NR77,O60231,Q9Y5P6 5 +Abnormality of the humeroradial joint 0.6133134522142072 1.0189215111597565 0.3082402304108296 1.0 0.5889238629560677 6 Q96L58,P16435 2 +Ectopic anus 0.4998171548548185 1.0119588259911885 0.3115577405459233 1.0 0.5936060526409989 12 P48651,P16435,Q9NX14 3 +Synostosis involving digits 0.6375564678484557 1.009846113168419 0.3125690232909528 1.0 0.5937403008687959 4 Q15233 1 +Distal amyotrophy 0.3472796741715338 1.0086066229734518 0.3131633297784468 1.0 0.5940173696779106 52 Q13057,Q8TD16,Q8TB36,P35637,Q9NVI7,Q99720,Q9BUK6,Q9H0B6,P21912,Q15120,Q8N0X7,O15269,Q9NR77,P43243,P31483 15 +Fatty replacement of skeletal muscle 0.6108943028289411 1.00806985222347 0.3134209294557246 1.0 0.5940173696779106 6 P22626 1 +Wide cranial sutures 0.5936124679656253 1.0060859081695923 0.3143742467683739 1.0 0.5950702739335563 7 O75844,O75718,P98175 3 +Adult onset 0.3406521175781944 1.0031415184285075 0.3157925849209972 1.0 0.5969210118626458 60 P36551,Q9NQZ5,O14979,P43304,P21912,Q9NZJ7,O15118,P41440,O76024,P43243,Q8IV08,P07602,P04062,P38435,P31751,P31483 16 +Phocomelia 0.5051244509516878 1.0031098034093422 0.3158078851601771 1.0 0.5969210118626458 2 Q9Y5S9 1 +Dyschromatopsia 0.6097528576631491 1.002952039002159 0.3158840024897023 1.0 0.5969210118626458 6 Q9H6K4,Q9H061 2 +Tall stature 0.3587123041067646 1.0017125580149864 0.316482439720271 1.0 0.5969696923911886 40 O95202,Q8NCH0,Q7LGA3,Q9NWM8,P16435,Q13363,P61978,Q15233 8 +Middle age onset 0.5579975463383884 1.0016459724101527 0.3165146091425503 1.0 0.5969696923911886 9 P07602,P02545,Q9NZJ7,P31483 4 +Emg chronic denervation signs 0.4979701494935984 1.0012840118210584 0.3166895202553714 1.0 0.5969696923911886 12 P22626,Q9NZJ7,P07602,O43681,O60313 5 +Nyctalopia 0.388210509734512 1.001246084763131 0.3167078515114572 1.0 0.5969696923911886 29 O75312,P50542,Q96S66,Q13432,Q10713,P40939,P38435,O75381 8 +Abnormal head movements 0.5397860684150118 0.9997640704335246 0.3174246974279435 1.0 0.5973482332497335 10 P35637,Q99720 2 +Decreased number of large peripheral myelinated nerve fibers 0.6375603105971107 0.9994553215388908 0.3175741721332139 1.0 0.5973482332497335 5 O15269,Q8TB36 2 +Hypertelorism 0.2959574319232531 0.997314370038342 0.3186119407560943 1.0 0.5987983208179863 155 Q8NCH0,P25054,O43924,Q9Y487,Q96A33,Q15067,P21964,P55263,P16435,Q13363,P55795,O14936,Q9UM00,Q15125,O95202,Q96L58,Q7LGA3,P48651,Q96J02,P04062,Q9UBM7,Q14739,O75844,Q8N0X7,Q01105,Q15233 26 +Limb tremor 0.5914857325333682 0.9961851747243388 0.319160181299891 1.0 0.5991080938841229 7 Q9NR77 1 +Polyhydramnios 0.354501204013661 0.9917847999206552 0.3213025139956609 1.0 0.6018387657815218 42 Q15125,Q9UBM7,Q70HW3,P21964,Q14739,O75844,P04062,Q9UM00 8 +Chorea 0.3244999213569887 0.9912235138033832 0.3215764512794941 1.0 0.601849505146943 71 P35637,Q96N66,Q99720,O43681,Q9NZJ7,O75306,Q9H6K4,Q01105,Q9BWD1,P07602,O14936 11 +Oligosacchariduria 0.5673028397586742 0.989359187440681 0.3224874351867708 1.0 0.6033028799992611 3 P04066 1 +Neoplasm of the oral cavity 0.5727490568070058 0.9883167104039894 0.3229975640302127 1.0 0.6037538806195729 8 O43924 1 +Increased connective tissue 0.5726910744977275 0.9880362080770556 0.323134915664417 1.0 0.6037591596594103 8 P07196,Q9Y5L0,P02545,O75431,P31751 5 +Proximal tubulopathy 0.4170599111938193 0.9871468222560644 0.3235706667962612 1.0 0.6040682067470223 20 O96000,Q86Y39,O75306,O43676 4 +Abnormal oral frenulum morphology 0.4717482714706288 0.98687461921396 0.3237041081164413 1.0 0.6040682067470223 13 O43924 1 +Severe postnatal growth retardation 0.5370625472186663 0.9854526718292558 0.3244017681219269 1.0 0.6046159199880432 10 Q13363,O76024 2 +Emg impaired neuromuscular transmission 0.6336166246111106 0.9827286819967668 0.3257409904095651 1.0 0.6066081182398874 5 O60313,Q9Y5P6 2 +Red green dyschromatopsia 0.5655824460814219 0.9813432106615008 0.3264235207763764 1.0 0.6073057078204456 3 Q9H6K4 1 +Abnormality of circulating glucocorticoid level 0.5361851018833939 0.9808437736964308 0.3266697881476572 1.0 0.6073297469787431 10 Q9H0R6,P16435 2 +Abnormality of the middle ear 0.3008665154505347 0.9799564619282884 0.3271076103324695 1.0 0.6076758791172044 105 Q96A33,Q9UBM7,Q14739,O75844,P21964,Q96L58,Q7LGA3,Q9NWM8,P21912,P16435,Q13432,Q13363,O43924,P01889,Q02978 15 +Schistocytosis 0.6302065022602521 0.9788273675324742 0.3276652848858894 1.0 0.6079213718759289 4 P41440 1 +Abnormal number of granulocyte precursors 0.5003660322108333 0.9783054814425024 0.3279232596763957 1.0 0.608097617786092 2 O75533 1 +Motor deterioration 0.6318575589819516 0.975274670737856 0.3294240312322631 1.0 0.6099237013904277 5 O75503 1 +Head tremor 0.4697329358202025 0.974597119422021 0.3297601430647829 1.0 0.6100426719186917 13 P35637,Q99720 2 +Hypoplasia of teeth 0.4365599782342242 0.9742169425815848 0.3299488340409273 1.0 0.6100596319353314 16 O75844,O75431 2 +Mildly elevated creatine kinase 0.4221812890178423 0.9738768346656111 0.3301176970761152 1.0 0.6100596319353314 18 Q9BUK6,P09651,P50570,P43243,P40939,Q16836,P31483 7 +Phenotypic variability 0.3103043052045076 0.9734835419852734 0.3303130360077664 1.0 0.6100596319353314 90 P36551,P21912,P07196,P46976,Q9NR77,P11166,O95470,Q70HW3,Q9H061,P02545,P57740,Q5T440,O95453,O00429,Q15125,Q8TD16,Q6P4A7,P41227,O60313,O14979,Q9NZJ7,Q14671,P43243,P07602,Q9Y5P6 25 +Abnormal circulating follicle stimulating hormone concentration 0.6284582565905221 0.9714610984442852 0.3313187159633042 1.0 0.6116653217784078 4 P16435 1 +Poikilocytosis 0.4689667312819194 0.9699304712722684 0.3320811502589254 1.0 0.6124313142737813 13 O75845,P11166,O14936,P41440 4 +Aplasia hypoplasia of the palmar creases 0.5631041182829657 0.96980638866587 0.3321430077857361 1.0 0.6124313142737813 3 Q8NCH0 1 +Fetal distress 0.4140768218018917 0.9649104396314596 0.334589672040146 1.0 0.6153773505856587 20 Q86Y39,Q9NVI7,O75306,O96000,Q9Y6M9,O43676 6 +Thoracic kyphosis 0.4561831436496323 0.9646890929951776 0.3347005598885011 1.0 0.6153773505856587 14 Q9UPP1,P19447,P08236,P04062,Q9UHX1,P51648 6 +Skin rash 0.4348444716015902 0.9625607239291464 0.3357680157753759 1.0 0.6167596624623051 16 Q06136,P21912,P28070,Q14739 4 +Gastrointestinal inflammation 0.4205790568436605 0.9623682337564354 0.3358646646742143 1.0 0.6167596624623051 18 P01889,P08183,Q13546 3 +Nonketotic hypoglycemia 0.6287328995369067 0.962045102134406 0.3360269486195382 1.0 0.6168052946439622 5 P23786 1 +Abnormal femoral head morphology 0.445359437065534 0.9610083634927225 0.3365479626432945 1.0 0.6175090990773123 15 Q96L58,Q7LGA3,Q6NUQ1,O75431 4 +Gait disturbance 0.2798574204215003 0.9601701246708144 0.3369696001041891 1.0 0.6177776001910134 268 Q13057,Q8TB36,P21912,O15118,P25054,P98175,P41440,P07196,O43924,Q9NR77,Q8IV08,P46976,P01889,P61978,P11166,O14773,Q14108,P35637,Q15067,Q99707,O14949,Q13363,P55795,Q10713,P05067,O14936,P09651,Q13153,O75503,P49366,Q8TD16,O75298,Q96N66,Q99720,P22626,Q8NBU5,P50570,Q7LGA3,Q15120,P40939,P04062,O60313,Q05086,Q9NVI7,Q9BUK6,Q9H0B6,O75844,Q5JRX3,Q9NZJ7,Q8N0X7,Q9H6K4,O15269,P43243,P07602,O43681,Q9Y5P6,P50402,P31483 58 +Abnormal muscle fiber protein expression 0.6000336901732939 0.959445590534432 0.3373343171958431 1.0 0.6181314031823913 6 P02545,Q9Y5P6,P50402 3 +Bilateral sensorineural hearing impairment 0.4051623808389387 0.957983512953484 0.3380710722989728 1.0 0.6181460152136272 22 P35637,Q15067,Q9NZJ7,P38159,P07602 5 +Abnormal lower motor neuron morphology 0.5485968371065828 0.9543132207489032 0.3399251178356652 1.0 0.6197804931593065 9 P35637,Q99720 2 +Functional abnormality of male internal genitalia 0.4161825853010903 0.9541742457729598 0.3399954487874805 1.0 0.6197804931593065 19 Q13423,P51809,P16435,O76024,P04062 5 +Glomerular sclerosis 0.3790679073618317 0.952645329530194 0.3407698018728602 1.0 0.6206878534112811 30 Q14108,O95470,P21912,O75431,P16930,Q02978,Q8N1F7 7 +Pseudoepiphyses 0.623633665348019 0.9511584762855876 0.3415239337617439 1.0 0.6208532244934353 4 Q13363 1 +Pseudoepiphyses of hand bones 0.623633665348019 0.9511584762855876 0.3415239337617439 1.0 0.6208532244934353 4 Q13363 1 +Pseudoepiphyses of the metacarpals 0.623633665348019 0.9511584762855876 0.3415239337617439 1.0 0.6208532244934353 4 Q13363 1 +Postural instability 0.4432937896536575 0.9474792713950896 0.3433946139391954 1.0 0.6234445903556267 15 P04062,Q9NR77,O75503 3 +Cerebral dysmyelination 0.5807787929476897 0.9464341933342192 0.3439271720272467 1.0 0.6241306401193081 7 Q9NZJ7 1 +Protruding tongue 0.5640305776979896 0.9461920805910886 0.3440506247003494 1.0 0.6241306401193081 8 Q05086 1 +Abdominal wall muscle weakness 0.5579628923810735 0.945916524075918 0.344191164682651 1.0 0.6241333119578737 3 P46976 1 +Aplasia hypoplasia involving the metacarpal bones 0.4180876117115158 0.9444769099924842 0.3449259957116317 1.0 0.6249607867395249 18 Q32P28,P16435,Q14739 3 +Joint stiffness 0.3411177349940093 0.9399765568959376 0.3472295857762317 1.0 0.6269277481556139 51 Q8NBU5,O75844,P16435,O76024,Q8TAA9,P08236,P54802,P01889,O75431,P51648 10 +Aplasia hypoplasia of the eyebrow 0.3525997072490198 0.939900108525384 0.3472688016744332 1.0 0.6269277481556139 40 Q15125,Q9NVI7,Q9UM00,O75844,P00813,P48449,P36507,Q96EK5,P61978,O75431 10 +Horizontal nystagmus 0.4024151670861206 0.9366854754771744 0.3489203696548848 1.0 0.628392704258075 22 O14773,Q9NZJ7,Q9H061,P07602,P04062,O60313 6 +Cranial asymmetry 0.5945477684733629 0.9349528130213398 0.3498126178974587 1.0 0.6289979890960189 6 Q13363,O95202,P40855 3 +Poor wound healing 0.6223205739404256 0.9349441871940616 0.3498170634544704 1.0 0.6289979890960189 5 P04062 1 +Aplasia hypoplasia of the earlobes 0.6219257363481596 0.933277730975109 0.3506765899205954 1.0 0.6302909633815108 5 P21964 1 +Heterotaxy 0.6216601585639379 0.9321569859631338 0.3512554013478466 1.0 0.6308260269104184 5 Q13363 1 +Migraine 0.4161085124455232 0.9302695485724464 0.3522315402198164 1.0 0.6317868498588017 18 P01889,P11166,Q9NQZ5,P05067 4 +Intrauterine growth retardation 0.2888490398061584 0.9300563645637407 0.3523419018772453 1.0 0.6317868498588017 164 P37268,P21912,O75306,O75027,P98175,O75845,O96000,O43924,Q9Y6M9,Q9Y487,Q9UHX1,Q15392,P21964,Q9H0R6,Q13363,O95202,Q86Y39,Q6P4A7,Q96L58,P48651,P40939,P04062,O43676,Q9BT22,O75312,Q9UBM7,O75844,Q16836,P51572 29 +Abnormality of the calf 0.3415908058048909 0.9287811290414252 0.3530025261122205 1.0 0.6324452443878825 47 Q13126,Q32P28,Q96L58,Q7LGA3,P16435,P08236,Q9NR77,O75431 8 +Abnormality of the ankles 0.3574786337890828 0.9277166843561442 0.3535545515589233 1.0 0.6331814953696919 35 O75844,Q9NZJ7,Q8N0X7,P07602,Q05086 5 +Wide nasal ridge 0.6165265064436203 0.9213263195142092 0.3568800838836088 1.0 0.6368500264292788 4 P61978 1 +Delayed menarche 0.6188212909457607 0.9201848988766383 0.357476144359794 1.0 0.6376601493985515 5 O00429,P02545,O75844 3 +Juvenile aseptic necrosis 0.5521749596572136 0.9190977715936076 0.3580444347412217 1.0 0.6382682135165644 3 Q8IWS0 1 +Breech presentation 0.5748550983991148 0.9189887395647836 0.3581014620398193 1.0 0.6382682135165644 7 Q9Y619,O60313,Q9UBM7 3 +Dermal translucency 0.5410031885682195 0.9161773644945468 0.3595738756692879 1.0 0.6406381714981199 9 O75844 1 +Renal tubular dysfunction 0.3637350346879322 0.9155321960564264 0.3599123083111077 1.0 0.6409866824207348 33 Q86Y39,Q9H9C1,O75306,O96000,P16930,Q9H267,O43676 7 +Impaired vibratory sensation 0.3899094078355312 0.912181225601101 0.3616733253731379 1.0 0.6438674669871649 25 O75298,O14773,Q9H0B6,Q15120,P07196,Q8N0X7,Q9NR77 7 +Thyroiditis 0.5731452749708419 0.9110790884951518 0.3622537037499906 1.0 0.6444501773516861 7 P00813,Q96J02 2 +Sparse eyebrow 0.3702201954556557 0.906792874859447 0.3645163384838823 1.0 0.6467675928996025 31 Q15125,Q9NVI7,Q9UM00,O75844,P02545,P48449,Q96EK5,P61978,Q92643,O75431 10 +Abnormality of facial skeleton 0.2759244890169642 0.9051433208384242 0.365389464391876 1.0 0.6474978896240355 253 Q9HC07,Q13057,P37268,Q8NCH0,P98175,P25054,O75845,O43924,Q96EK5,Q9Y487,Q86XL3,Q9UHX1,Q15392,Q9NX14,P21964,O60488,P16435,Q13432,Q13363,P55795,P36507,O14936,O75431,P00813,Q9UM00,Q15125,Q8TD16,O95202,Q16625,Q96L58,Q7LGA3,P48651,Q92917,P28070,P04062,Q05086,Q9BT22,Q9NVI7,Q9BUK6,Q9UBM7,Q14739,O75844,Q9BSJ2,O75381,Q9H267,Q15233 46 +Abnormal endocrine physiology 0.6151981838393079 0.90492772301518 0.3655036789469679 1.0 0.6474978896240355 5 P16435 1 +Thickened ribs 0.5490130204946093 0.9044841228354276 0.3657387495489685 1.0 0.6474978896240355 3 P54802 1 +Thickened nuchal skin fold 0.5214769333857698 0.9037579893608694 0.3661237425089987 1.0 0.6474978896240355 10 P50542,Q15125,O75381,P61978 4 +Abnormal heart valve physiology 0.314532476907306 0.9035521580403042 0.3662329193980376 1.0 0.6474978896240355 73 Q15125,P40939,Q9NX14,O75844,Q96L58,O75306,P55263,P36507,P01889,O75431,P04062,Q86TI2,Q9UHX1,Q15233 14 +Weak voice 0.6122569910485838 0.9034532276121404 0.3662854012244754 1.0 0.6474978896240355 4 P04062 1 +Eeg with polyspike wave complexes 0.5872579949821423 0.902491561916792 0.3667958018449149 1.0 0.6480586819470141 6 Q14108 1 +Abnormality of the palpebral fissures 0.2859964803404588 0.9018771860474656 0.3671221116420167 1.0 0.6481683859360232 172 Q8IWS0,Q8NCH0,P98175,P25054,O75845,P35606,Q96EK5,P61978,Q9Y487,Q86XL3,Q9UHX1,Q15392,P21964,O60488,P16435,Q13363,P55795,P36507,O14936,Q9UM00,Q15125,O95202,Q7LGA3,P38159,Q92917,P50542,Q05086,Q13555,Q9NVI7,Q9UBM7,O75844,Q9BSJ2,Q8N0X7,O75381,Q15233 35 +Ulnar deviation of the hand or of fingers of the hand 0.5209748940438806 0.901133610160514 0.367517284577133 1.0 0.6485299668577272 10 Q96L58,Q14739 2 +Pulmonic stenosis 0.3910017534784954 0.9009480963866776 0.3676159170423481 1.0 0.6485299668577272 24 O75306 1 +Coarse hair 0.4253992863561964 0.8984482577565882 0.3689466187124934 1.0 0.650433337376829 16 Q96A33,Q9Y487,P54802 3 +Centrally nucleated skeletal muscle fibers 0.5862977189558306 0.8982234448568721 0.3690664366610576 1.0 0.650433337376829 6 P50570,P22626 2 +Myoclonic spasms 0.5476248516147053 0.8980772812168951 0.3691443500978484 1.0 0.650433337376829 3 Q10713 1 +Abnormal nerve conduction velocity 0.3533748328431156 0.8978330876615183 0.3692745418084135 1.0 0.650433337376829 36 Q9Y619,Q8TB36,Q99720,P50570,Q9NZJ7,Q15120,P07196,P02545,P19447,O15269,Q9NR77,P43243,O60231,P07602,O43681 15 +Abnormal periventricular white matter morphology 0.3614422916112039 0.8941795514226257 0.3712258312507295 1.0 0.6529585722677267 33 O00429,O95202,O43681,Q9NZJ7,Q13363,P19447,Q5JTZ9,Q9Y5P6,P27635,P07602,P51571,O60313,Q13153,O75503,Q9UHX1 15 +Microcytic anemia 0.5692808324671201 0.8932242066320162 0.3717371174079478 1.0 0.6529585722677267 7 Q13546,Q9UBX3 2 +Abnormal meningeal morphology 0.4109393919295248 0.8931885346780348 0.3717562169548873 1.0 0.6529585722677267 18 P21964,O75845,Q8TAA9,Q10713,Q9Y5P6 5 +Hypointensity of cerebral white matter on mri 0.5849652961982132 0.8923045368317524 0.3722297231889682 1.0 0.6529585722677267 6 Q9NZJ7 1 +Sleep wake cycle disturbance 0.6119600908304809 0.8913142597502254 0.3727606007548092 1.0 0.6529585722677267 5 Q05086 1 +Increased circulating iga level 0.4835285505124503 0.8911001579320567 0.372875440219067 1.0 0.6529585722677267 2 Q9Y5L0 1 +Chronic noninfectious lymphadenopathy 0.4835285505124466 0.8911001579320376 0.3728754402190772 1.0 0.6529585722677267 2 Q9UNW1 1 +Antiphospholipid antibody positivity 0.483528550512446 0.8911001579320351 0.3728754402190786 1.0 0.6529585722677267 2 P42224 1 +Lymphocytosis 0.4835285505124422 0.891100157932016 0.3728754402190888 1.0 0.6529585722677267 2 Q03252 1 +Sclerocornea 0.5357956624069969 0.8900880326612705 0.3734186183657786 1.0 0.6531404975188451 9 O95202,Q9NX14,Q9UBM7,Q13363,P53701 5 +Emg myopathic abnormalities 0.3845526180022449 0.8900648938230155 0.3734310420306053 1.0 0.6531404975188451 26 Q9H845,P22626,Q9BUK6,P50570,P07196,Q9Y5L0,P02545,P46976,O60231,P09651,P53007,P50402,P31483 13 +Macrogyria 0.611500207773193 0.8893826287568684 0.3737974775977484 1.0 0.6533661644407099 5 Q15392 1 +Prenatal movement abnormality 0.3379520059268857 0.8892825862981248 0.3738512277815826 1.0 0.6533661644407099 47 Q8TD16,O95202,Q16637,Q9UBM7,Q70HW3,O75844,P50570,Q92917,P02545,Q13363,P40855,Q7KZN9,P04062,Q9Y5P6,Q99567,Q9UM00 16 +Abnormal cerebral ventricle morphology 0.2859227875723144 0.8882471139019102 0.3744078407686175 1.0 0.6538297234900995 186 Q8NCH0,O75306,P23786,Q8TAA9,P35606,P08236,Q96EK5,Q9Y487,Q86XL3,Q9UHX1,P11166,Q15392,P21964,P16435,Q13363,Q10713,O14936,Q9UM00,Q15125,Q8TD16,P53634,O95202,Q96L58,P48651,P04062,O75312,Q9UBM7,Q9NZJ7,Q9BSJ2,Q01105,P07602,Q9Y5P6 32 +Abnormality of the carpal bones 0.443688072407596 0.8857510972928384 0.3757516670651517 1.0 0.6556662059830486 14 Q15125,Q96L58,P16435 3 +Hepatocellular carcinoma 0.3997462389736831 0.885433193564195 0.3759230363038561 1.0 0.6556711623977975 21 P36551,P16930,P06737 3 +Peripheral hypomyelination 0.544831834958897 0.8852038502984088 0.3760466960810897 1.0 0.6556711623977975 3 Q8TB36 1 +Abnormality of the forehead 0.2784976636425226 0.8842171568700415 0.3765789984457917 1.0 0.6561294119479739 240 P36551,Q13057,P13073,Q8NCH0,Q9H9C1,P98175,P23786,P25054,O75845,P35606,O43924,Q96EK5,P61978,Q9Y487,Q86XL3,Q9UHX1,P11166,Q96A33,Q15392,Q15067,P55263,P16435,Q13363,Q10713,P36507,O14936,O75431,Q13153,Q9UM00,Q15125,O95202,Q16625,Q96L58,Q7LGA3,P48651,Q92917,Q96J02,P50542,Q92643,Q13555,Q9NVI7,O75312,Q9UBM7,Q14739,P78347,Q9BSJ2,O75381,Q9H267,Q15233 49 +Abnormal full field electroretinogram 0.5672522442993234 0.8838644535736628 0.3767693879045002 1.0 0.6561294119479739 7 Q15067 1 +Abnormal light and dark adapted electroretinogram 0.5672522442993234 0.8838644535736628 0.3767693879045002 1.0 0.6561294119479739 7 Q15067 1 +Poor motor coordination 0.4997521329136022 0.8801419751247974 0.3787824024656974 1.0 0.6582497770991065 11 O75503,Q10713 2 +Abnormality of head blood vessel 0.4025749941871555 0.8792603953191305 0.379260104454689 1.0 0.6584600962447368 20 P78347,P21964,P48651,Q9NZJ7,P07602 5 +Pace of progression 0.2918260826226871 0.8775487416808798 0.380188656607981 1.0 0.6590524105278559 146 Q13057,P27544,Q8TB36,P07196,P41440,P35606,Q9Y6M9,Q9NR77,Q8IV08,P46976,O14773,Q14108,O95470,P28288,Q16637,Q96BR5,P55263,P02545,P05023,P57740,P54802,Q10713,Q5T440,O00429,O75298,Q9NQZ5,Q99720,Q8NBU5,P50570,Q9P0J0,Q15120,Q5JTZ9,Q9NRG9,P04062,O60313,Q8N1F7,Q13126,O14979,Q9H0B6,Q14671,P50402,P31483 42 +Abnormal circulating protein concentration 0.2944110030572316 0.8765375475184645 0.3807378735649751 1.0 0.6597496434593082 131 Q9HC07,P36551,Q9H845,P23786,P41440,Q9Y487,O95470,Q9H0R6,Q8N511,P22626,Q9NWM8,Q15120,P40939,P16930,Q8N1F7,Q8NFH4,Q9BT22,Q9BUK6,O14979,Q5JRX3,P42167,O43772,P43243,Q16836,Q9Y5P6,P50402,P31483 27 +Congenital contracture 0.3511045608648986 0.875789285953372 0.3811445956353161 1.0 0.6601995157125815 36 Q8TD16,Q96A33,Q15392,O75844,Q8NCH0,Q9H9C1,P04062,Q9H267 8 +Prolonged partial thromboplastin time 0.6054720586363689 0.8751328170561278 0.3815016428163491 1.0 0.66041144861386 4 P38435 1 +Glucose intolerance 0.3034653342051981 0.8746270583534881 0.3817768600910276 1.0 0.66041144861386 90 Q86Y39,Q06136,O75844,P43304,O75306,O76024,Q8TAA9,O96000,Q9Y6M9,Q96J02,O75431,P31751,O43676 13 +Flat forehead 0.5422486078066747 0.8733187121348198 0.382489384036033 1.0 0.6607334787947375 3 Q8NCH0 1 +Focal segmental glomerulosclerosis 0.4017411350993266 0.8730595139172259 0.3826306397922288 1.0 0.6607334787947375 20 O75431,Q14108,O95470,Q8N1F7 4 +Flared metaphysis 0.5647733229969818 0.872439718430515 0.3829685405582606 1.0 0.6610609148443614 7 Q96L58,Q14739 2 +Abnormal retinal artery morphology 0.4106643631637507 0.8714452735635564 0.3835110749281931 1.0 0.6610609148443614 17 P07602,Q9NZJ7 2 +Orthostatic hypotension 0.4413502376842863 0.8710145082496826 0.3837462314424378 1.0 0.6610609148443614 14 P07602,P04062,Q9NZJ7 3 +Polycystic kidney dysplasia 0.4753538874179919 0.8709398408785679 0.3837870016344191 1.0 0.6610609148443614 12 P23786 1 +Beaking of vertebral bodies 0.5482197511298814 0.870143831959264 0.3842218065616765 1.0 0.6612298292736127 8 Q96L58,P08236,Q9UM00 3 +Cerebellar cyst 0.3623532908619268 0.8701030850297546 0.3842440719130084 1.0 0.6612298292736127 32 Q9Y487,P23786 2 +Abnormality of peripheral nerves 0.3469989977690652 0.8696767875851464 0.3844770610253372 1.0 0.6613771751175598 39 Q9Y619,Q8TB36,Q99720,P50570,Q9NZJ7,Q15120,P07196,P02545,P19447,O15269,Q9NR77,P43243,O60231,P07602,O43681 15 +Osteolysis 0.3846494531550518 0.8692740735516428 0.384697240189902 1.0 0.6615023808322913 25 Q14108,P22626,O75844,P25054,O75431,P04062 6 +Abnormal conjugate eye movement 0.2756788713907951 0.8655331387280651 0.3867462353927149 1.0 0.6637541508384339 247 Q8NCH0,O75306,O15118,P25054,O75027,O96000,O43924,Q9Y6M9,Q7KZN9,Q9Y487,Q9UHX1,P11166,P35637,Q15392,Q15067,O95470,P21964,Q9NX14,O60488,Q9H061,P16435,Q13363,P55795,Q10713,P36507,O14936,P38435,Q9UM00,O95202,Q86Y39,Q99720,Q7LGA3,P40939,P04062,O60313,Q05086,O43676,Q9BT22,Q9NVI7,Q9UBM7,Q14739,Q9NZJ7,P51572,P07602,O75381,Q9Y5P6,Q15233 47 +Abnormality of the external nose 0.2847128508694168 0.8647175259325613 0.38719384768875 1.0 0.6642683441999656 186 P98175,P23786,P25054,O75845,O43924,Q96EK5,P61978,Q9Y487,Q9UHX1,P11166,Q96A33,Q15392,P21964,O60488,P16435,Q13363,P42892,P55795,Q10713,O14936,O75431,Q15125,O95202,Q96L58,Q7LGA3,P38159,Q96J02,P04062,Q9NVI7,O75312,Q9UBM7,O75844,Q9BSJ2,O75381 34 +Abnormal macroscopic urine appearance 0.4038967994242257 0.8644310032584125 0.3873511676957242 1.0 0.6642843105152504 19 P36551,Q8NFH4,P53004,P23786,P57740,Q14C86,Q8N1F7 7 +Abnormality of corneal stroma 0.4399070257670562 0.8619237218163754 0.3887294941877588 1.0 0.6657993204969903 14 P50542,P10619,Q16625,O75845,P19447,P18074,P04062 7 +Abnormality of endocrine pancreas physiology 0.6021684091076355 0.861383204110457 0.3890270234837478 1.0 0.6657993204969903 4 P16930 1 +Pleural effusion 0.5462976825799031 0.8609364535773061 0.3892730430000228 1.0 0.6657993204969903 8 Q14739 1 +Upper limb muscle weakness 0.3923771711788472 0.858954006835266 0.3903658914181593 1.0 0.6674141412132188 22 P36551,P50570,P07196,Q8N0X7,P46976,Q9Y5P6,P50402 7 +Impairment of activities of daily living 0.335106832417413 0.858411820944813 0.3906651025302612 1.0 0.6674567617412683 47 P11166,O75298,P35637,Q99720,P21964,O60488,Q9NZJ7,P07196,Q8TAA9,O15269,P07602,O43681 12 +Abnormality of extrapyramidal motor function 0.3186640363379379 0.8583698680484212 0.390688260493385 1.0 0.6674567617412683 68 Q13057,P11802,P98175,P31930,P06865,P11166,P35637,O14949,P05067,Q99720,Q96IX5,P04062,P78347,Q9H0B6,P35610,Q9NZJ7,O96008,P35270,Q9H6K4,P19447,P07602 21 +Abnormal cerebral cortex morphology 0.2842686850330371 0.8572491380318608 0.3913072111867699 1.0 0.6682598035792326 183 P37268,Q9H9C1,O75306,P23786,P35606,O43924,Q9Y487,Q86XL3,P35637,Q15392,O76024,Q10713,P05067,O14936,O75503,Q9UM00,Q96N66,Q7LGA3,P04062,Q05086,Q9UBM7,Q9BSJ2,Q01105,P51572,O75381,Q9H267 26 +Abnormality of the gingiva 0.345408806316958 0.8537806270692246 0.3932265505406345 1.0 0.6706388566540754 39 Q14108,Q15392,Q9UBM7,Q14739,P08236,P04062,Q9UM00 7 +Slanting of the palpebral fissure 0.2897013948718335 0.8536516876087497 0.3932980104085397 1.0 0.6706388566540754 149 Q8NCH0,P25054,O75845,P35606,Q96EK5,P61978,Q9Y487,Q86XL3,Q9UHX1,Q15392,P21964,O60488,P16435,Q13363,O14936,Q9UM00,Q15125,O95202,Q7LGA3,Q05086,Q9NVI7,Q9UBM7,O75844,Q9BSJ2,Q8N0X7,O75381,Q15233 27 +Submucous cleft of soft and hard palate 0.3954625332606112 0.8529566702006076 0.3936833332468417 1.0 0.6707861805663726 21 Q9Y619,Q15392,P62266,O75844,Q7LGA3,P48651,P36507 7 +Abnormality of muscle size 0.2829663707800086 0.849878991710393 0.395392366656508 1.0 0.672665075986074 169 Q13057,Q8IWS0,Q8TB36,P21912,P07196,P46976,Q9NR77,P61978,Q9Y487,Q96A33,P35637,Q16637,Q15165,P55263,Q10713,P09651,Q8TD16,O75298,Q9HCC0,Q6P4A7,Q99720,P22626,P50570,Q7LGA3,Q9NWM8,Q15120,Q92804,P50542,O60313,Q05086,Q13126,Q9NVI7,Q9BUK6,O14979,Q9H0B6,Q8N0X7,O15269,P43243,Q9Y5P6,P50402,P31483 41 +Azoospermia 0.5753188688233235 0.849576021122525 0.3955608481579042 1.0 0.672665075986074 6 P04062,P51809 2 +Easy fatigability 0.4018284980976407 0.8493522068279161 0.3956853388153376 1.0 0.672665075986074 19 P61978,P50570,P21912,Q9NWM8,Q9BQP7,P53007,Q9Y5P6 7 +Upper limb spasticity 0.5595943958846975 0.84861993774505 0.3960928091010829 1.0 0.6731028122853692 7 P35637,Q99720 2 +Molar tooth sign on mri 0.5979616062126876 0.843915545627341 0.3987166005924503 1.0 0.6767927774050366 4 O43924 1 +Reduced visual acuity 0.2963399179226314 0.8409862273417624 0.4003556501314154 1.0 0.677705727835648 98 P50897,P21912,O75306,P25054,O96000,Q9Y6M9,P01889,Q9UHX1,P61960,Q99707,Q9H061,Q10713,Q86Y39,O60313,O43676,Q9NZJ7,Q9H6K4,P07602,O43681,Q9Y5P6,Q8WWV3 21 +Ectopia pupillae 0.5998941740400696 0.8407955589215788 0.4004624755392465 1.0 0.677705727835648 5 Q13363 1 +Sparse eyelashes 0.416797495364668 0.8402076716686074 0.4007919577432324 1.0 0.6778109433127597 16 O75844,Q15125 2 +Abnormal enzyme coenzyme activity 0.2874910960378578 0.8397969336558105 0.4010222530168377 1.0 0.6778862039697053 154 Q9HC07,Q9H845,Q9H9C1,O15118,P23786,O75845,P41440,P01889,Q96A33,P28288,Q15067,Q99707,P55263,Q10713,P09651,O75431,P00813,Q8N511,Q96EY8,Q9HCC0,P22626,P28070,Q6NUQ1,P40939,P04062,P16930,Q14739,Q5JRX3,Q9NZJ7,O43772,P06737,P07602,Q16836,Q9H267 34 +Arthrogryposis multiplex congenita 0.3625878104544542 0.8381378510267712 0.4019532868024096 1.0 0.678948570255632 31 Q15392,O75844,Q8NCH0,Q9H9C1,P04062,Q9H267 6 +Constitutional symptom 0.2828058320292029 0.8377681274863696 0.4021609425352339 1.0 0.6789904800191146 203 P36551,Q9H845,P21912,P23786,P25054,Q8TAA9,Q9NR77,Q01844,P01889,Q02978,Q13546,P11166,Q14108,P35637,Q70HW3,P21964,Q15165,P42892,O14936,Q99720,P22626,P28070,Q92804,P40939,P04062,O60313,Q8N1F7,Q8NFH4,Q15800,Q9BUK6,Q14739,O75844,Q13423,Q9NZJ7,Q9H6K4,O15269,P43243,P06737,P07602,O43681,P50402 41 +Cerebellar malformation 0.332219634464653 0.8353098765648962 0.4035432579228772 1.0 0.6800984384370533 48 Q15125,Q9UBM7,P16435,P23786,Q8TAA9,Q9Y487 6 +Generalized hypotonia 0.2808801474888951 0.8341821974018792 0.4041783215028431 1.0 0.6804025560551034 306 Q9HC07,Q8IWS0,P50897,Q9H845,P13073,Q8NCH0,Q9H9C1,P21912,O15118,P23786,P25054,P98175,O75845,O43924,Q9NR77,Q9Y6M9,Q7KZN9,Q96EK5,P61978,Q9Y487,Q9UHX1,P61960,Q96A33,O95470,Q70HW3,Q99707,O14949,P55263,Q13363,Q10713,Q9BWD1,O75431,Q8N511,Q96EY8,Q13153,Q15125,O95202,Q86Y39,Q96N66,Q6P4A7,Q9HCC0,Q99797,Q96L58,P48651,P50570,P49770,Q9P0J0,Q9UBX3,Q96J02,P40939,P50542,Q05086,O43676,Q13555,Q9BT22,Q9NVI7,Q9BUK6,Q9UBM7,Q9NZJ7,O43772,Q8N0X7,Q9Y5P6,Q01105,P46977,P07602,O43681,Q16836,O75381,Q9H267,Q15233 70 +Abnormality of the achilles tendon 0.4465600775235605 0.8338975078723952 0.4043387417031656 1.0 0.6804025560551034 13 Q8TD16,Q15041,P02545,O60313,Q08J23,P50402 6 +Toxemia of pregnancy 0.5717200448330615 0.8336957560121339 0.4044524502721589 1.0 0.6804025560551034 6 P49366,O43772,Q14739 3 +Absence of subcutaneous fat 0.5713614911528959 0.8321155469909037 0.4053437271355506 1.0 0.6815970953107349 6 O75844,P02545,P19447 3 +Hyperthyroidism 0.5546810289719091 0.8260875572121896 0.4087544254934436 1.0 0.6865605769515626 7 P21964 1 +Neoplasm of the small intestine 0.5962674563091213 0.8256822770018485 0.4089843484778135 1.0 0.6866112434523518 5 P21912,P25054 2 +Short lingual frenulum 0.5929316800416742 0.8230941865288814 0.4104544344951479 1.0 0.6883933868850948 4 O75844 1 +Impaired tactile sensation 0.5693110372072462 0.8230858788119974 0.4104591584903105 1.0 0.6883933868850948 6 Q9NR77 1 +Abnormal fear anxiety related behavior 0.3021547092072952 0.8226554314455471 0.4107039668360868 1.0 0.6884209828616508 85 P36551,P11166,P35637,Q9BUK6,P21964,Q15165,Q7LGA3,P21912,Q8N0X7,O76024,P55795,Q92804,Q02978,O75503,Q15233 15 +Lower extremity joint dislocation 0.3220701180539395 0.8215741258936873 0.4113193202203129 1.0 0.6890634972559777 63 Q8TD16,Q96A33,Q15125,O95202,Q8NBU5,Q9UBM7,P21964,Q96L58,O75844,P25054,Q13363,Q9Y487,Q9Y5P6 13 +Preaxial polydactyly 0.4882996265889812 0.8178475374734662 0.4134442499133572 1.0 0.6919599462323701 11 Q13363,O95202,O43924 3 +Abnormality of the nasal dorsum 0.3305864835541174 0.8174610429321723 0.4136650035074529 1.0 0.6919599462323701 48 Q15125,O95202,O75844,P25054,Q13363,Q96J02,P61978,O75431 8 +Optic atrophy 0.2845750726806186 0.8166328109323258 0.4141382986176865 1.0 0.6920165310219755 159 P50897,O75306,P98175,P41440,Q7KZN9,P01889,Q15067,P21964,Q9H061,Q13363,O76024,P36507,O14936,Q15125,O95202,Q86Y39,P49770,Q9P0J0,O60313,Q9NVI7,O75312,Q9UBM7,Q9H0B6,Q9NZJ7,Q9BSJ2,O75381,Q9H6K4,P07602,O43681,P51572,Q9Y5P6 31 +Elevated tissue non specific alkaline phosphatase 0.468887262079073 0.8161906467956092 0.41439110546614 1.0 0.6920165310219755 2 Q13043 1 +Telangiectasia of the skin 0.4323365214686001 0.8143317606748747 0.4154549195393553 1.0 0.6926306385188064 14 Q14739,Q8IZA0,P19447,P02545,O95453 5 +Memory impairment 0.3559957310035005 0.8119217189451656 0.4168365510852254 1.0 0.6941604605827428 32 Q9NZJ7,O96008,P01889,O43681,P07602,P05067,P31483 7 +Left ventricular hypertrophy 0.3934261263449694 0.8113250132254007 0.4171790493044174 1.0 0.694473135488956 20 O75431,P21912,Q15233 3 +Abnormalities of placenta or umbilical cord 0.4426204424728869 0.8101070320299394 0.4178786630570359 1.0 0.6953798441972477 13 O75844 1 +Abnormal pupil morphology 0.5031335803937751 0.8082703041220303 0.4189349935743449 1.0 0.6968792628471683 10 Q13363,Q9NR77 2 +Apnea 0.3056131907892425 0.8068001392070692 0.4197816389375335 1.0 0.6980288979442942 74 P11166,Q96A33,Q86Y39,Q9NZJ7,O75306,P98175,P23786,O43772,O76024,O43924,Q10713,P07602,P04062,O60313,Q15233 15 +Abnormal circulating iga level 0.5027565772990467 0.8063178461346584 0.4200596030192707 1.0 0.6982324067964767 10 P13051,Q13724,Q9Y5L0,P50851,Q96J02,P00813 6 +Brachycephaly 0.3292405425267952 0.8056250566075387 0.4204590735074256 1.0 0.6983790976688846 53 Q96A33,Q15067,Q8NCH0,P16435,O75431,P04062 6 +Abnormality of malar bones 0.328256526869685 0.8030198094470942 0.4219632849603201 1.0 0.6998493629446805 55 Q9HC07,Q15125,Q14739,P21964,Q96L58,P16435,Q9Y487,Q15233 8 +Myoclonic seizure 0.3329876082258715 0.8028216318011363 0.4220778372772693 1.0 0.6998493629446805 44 Q96N66,P21912,Q9NZJ7,Q01105,P07602,P04062,O75503,Q8WWV3 8 +Myelomeningocele 0.5265624280252237 0.8016460698878338 0.4227577201840722 1.0 0.7004449476888847 3 Q8TAA9 1 +Generalized hyperpigmentation 0.4852973255189028 0.8015811023409198 0.4227953126758441 1.0 0.7004449476888847 11 Q13423,O95453,P51648,P36507 4 +Abnormality of circulating enzyme level 0.3016271574573052 0.7997856957520054 0.4238349720707524 1.0 0.7016493377549011 82 Q9HC07,Q9H845,P23786,P07196,Q96BR5,Q9H0R6,P09493,P09651,P22626,P50570,Q9NWM8,Q15120,P40939,Q9BUK6,O14979,P78347,Q5JRX3,P42167,O43772,P43243,Q16836,Q9Y5P6,P50402,P31483 24 +B lymphocytopenia 0.547570411463165 0.7936053474856811 0.4274252183893856 1.0 0.7064749559791402 7 Q13546,Q13432 2 +Small nail 0.3405371235616325 0.7934134394326872 0.4275369831638469 1.0 0.7064749559791402 38 O75431,P23786 2 +Stillbirth 0.4836208868366621 0.7925114082980634 0.4280625424322435 1.0 0.7070830660419245 11 O75844,P16435,Q14739 3 +Dysarthria 0.2883967837626485 0.7907668830822552 0.4290800384937019 1.0 0.7070853772841259 138 Q13057,Q96CU9,Q13409,O75306,O15118,O75027,P41440,P07196,Q8IV08,Q7KZN9,P51648,P11166,O14773,Q14108,P35637,Q96BR5,O76024,Q10713,P36507,O75503,P49770,Q9P0J0,Q5JTZ9,Q9NRG9,Q9NR50,P04062,Q13144,Q9H0B6,P78347,Q9NZJ7,P35270,O43819,Q8N0X7,Q9H6K4,Q14671,P43243,P07602,O43681,Q15233 39 +Paraplegia 0.3300893674587851 0.7905144314095699 0.4292273975483167 1.0 0.7070853772841259 45 Q9Y619,P11166,O75298,Q96CU9,Q9H0B6,Q96L58,P04062,O75306,Q9P0J0,Q8N0X7,Q7KZN9,Q5T440,O60313 13 +Aplasia hypoplasia of the femur 0.4393632536045926 0.7904773184334586 0.4292490633152037 1.0 0.7070853772841259 13 Q96L58,Q9UHX1,O75431 3 +High pitched voice 0.5308434420078836 0.7872809070521578 0.4311174439714684 1.0 0.7087381276717767 8 O75431 1 +Abnormality of dental structure 0.3191421863356828 0.7860833963371625 0.4318186308904848 1.0 0.7096309100829351 63 Q9HC07,Q9UBM7,P21964,Q96L58,O75844,P25054,O75431,Q9Y487,P51648 9 +Increased circulating antibody level 0.460460321582106 0.7857392777357063 0.432020247253823 1.0 0.7097023681095014 12 Q14108,P28070 2 +Emg abnormality 0.3128661623099259 0.7850708537171562 0.4324120273926324 1.0 0.7100860515690209 68 Q8TB36,Q9H845,P07196,P46976,Q9NR77,O14773,Q16637,P09651,P22626,Q15120,O60313,Q9BUK6,P42167,Q9NZJ7,O15269,P43243,P07602,O43681,Q9Y5P6,P50402,P31483 21 +Poor suck 0.376491754926369 0.7845302608010497 0.4327290329216231 1.0 0.7103467080293506 24 P22695,Q9UBM7,P50542,O75306,O43819,P40939,Q05086,Q15233 8 +Reticulocytosis 0.4816970796405883 0.7821157298446141 0.4341465632375587 1.0 0.7118884647185586 11 P36551,O14936 2 +Abnormality of the clitoris 0.3894782169886379 0.7820926429625028 0.4341601300934359 1.0 0.7118884647185586 20 Q9Y619,Q9NX14,Q9UBM7,P16435,P50542,P51809,O75381 7 +Vocal cord paralysis 0.3952872037605428 0.7812949832814514 0.4346290200327558 1.0 0.712163213547648 18 P21912,P43243,Q9NR77,Q02978,P50402 5 +Abnormal size of the clitoris 0.3976042638668912 0.7797901829749498 0.435514385688597 1.0 0.7130932371289396 17 Q9Y619,Q9NX14,Q9UBM7,P16435,P50542,P51809,O75381 7 +Abnormality of prenatal development or birth 0.2800731242740883 0.7788520015229202 0.4360669010997549 1.0 0.713477306648086 200 Q9Y619,Q96CU9,O75306,O15118,P23786,Q8TAA9,O96000,P08236,P40855,Q9Y6M9,Q7KZN9,P61978,Q9Y487,Q9UHX1,Q99567,O75718,Q16637,Q9NX14,Q70HW3,P21964,Q9H0R6,P16435,P02545,Q13363,P57740,P36507,Q5T440,P46783,Q9UM00,P49366,Q15125,Q8TD16,O95202,Q86Y39,Q96L58,Q7LGA3,P50570,Q92917,P40939,P50542,P04062,O60313,O43676,Q9BT22,Q9NVI7,Q9UBM7,Q14739,O75844,P78347,O43772,O75381,Q9Y5P6 52 +Type 1 muscle fiber atrophy 0.544249760697526 0.7784923382201537 0.4362788217249034 1.0 0.7135639037541422 7 P02545,P50402,P61978 3 +Infantile muscular hypotonia 0.326357575496659 0.777367398982455 0.436942040881533 1.0 0.7136959291910708 50 Q9NZJ7,O75306,P07602,O14936,Q9Y487 5 +Peripheral neuropathy 0.286917109567781 0.7772727697498296 0.436997856952144 1.0 0.7136959291910708 142 P36551,Q9Y2R0,Q13057,Q8IWS0,Q8TB36,Q15041,Q96CU9,O75306,P07196,P41440,Q9NR77,P31930,Q8IV08,P01889,Q7KZN9,O95470,Q15067,Q96BR5,O76024,P05023,P54802,Q10713,P09651,Q5T440,P04066,O00429,P22626,P50570,Q9P0J0,Q15120,Q9NRG9,P40939,P50542,P16930,O60313,Q9NVI7,Q9H0B6,Q9NZJ7,O43819,P19447,O15269,O60231,P07602,O43681,P53007,Q16836 46 +Skeletal muscle hypertrophy 0.3398652153487754 0.7762822683449719 0.4375823402810685 1.0 0.7141343793387038 37 Q96A33,P78347,P50570,P21912,Q7LGA3,P02545,Q9Y5P6,Q9NR77,Q10713,O60231,P61978,Q05086,P04066 13 +Abnormal talus morphology 0.4072626279414597 0.7759045028060985 0.4378053737642684 1.0 0.7142386468389811 16 O75844,P98175,P16435,P02545,P18074,Q9UHX1,Q99567 7 +Multiple joint contractures 0.3912453861258824 0.7724055521635408 0.4398742664853403 1.0 0.7165627922211996 19 Q9H0B6,O75844,Q96L58,Q92917,P41440,P02545,P19447,Q9Y5P6,Q99567 9 +Shuffling gait 0.4956143829974468 0.7694220091079254 0.441642827106588 1.0 0.7184099340537756 10 O75844,P02545,P04062 3 +Abnormal sensory nerve conduction velocity 0.5822006929925603 0.7674280745846397 0.4428270418500453 1.0 0.7199013363519038 5 Q9NR77 1 +Abnormality of the skull base 0.3296164887795585 0.7673381711967681 0.4428804789811957 1.0 0.7199013363519038 44 Q15125,Q9UBM7,Q14739,Q96L58,P23786,Q10713,Q9Y487 7 +Synostosis involving bones of the hand 0.4568104937000127 0.7649750255594546 0.4442864163030184 1.0 0.7211419299703243 12 Q96L58,Q15233,P16435,P25054 4 +Abnormal adipose tissue morphology 0.3254263456820784 0.7636262333956962 0.4450900115089367 1.0 0.7221850945958451 52 Q9BUK6,O75844,P42167,P21912,P25054,Q8TAA9,P28070,O75431,Q9Y487,P31751 10 +Heat intolerance 0.5554302285007491 0.762303891870649 0.4458786516329684 1.0 0.7224090732447572 6 P61978,Q05086 2 +Abnormal gastrointestinal motility 0.3768508689702734 0.7618391762234681 0.4461559954183673 1.0 0.7224090732447572 23 P36551,P35637,Q9UBM7,Q01844,P61978,P16930 6 +Oculomotor apraxia 0.3768427767449051 0.761775777895047 0.4461938393570559 1.0 0.7224090732447572 23 O00429,O14773,O96008,O43924,Q10713,Q9NQT5,P05067,P04062 8 +Generalized onset motor seizure 0.3305462664324728 0.7602524242033395 0.4471037140911138 1.0 0.7236211571730684 43 Q96N66,P21912,Q9NZJ7,Q01105,P07602,O14936,P04062,Q05086 8 +Abnormality of the abdominal organs 0.2768782965499474 0.7580935528951799 0.4483949790089645 1.0 0.7244522345340149 301 Q9HC07,P36551,Q8NCH0,Q9H9C1,P21912,O75306,O15118,P23786,P25054,O96000,P08236,Q9Y6M9,Q01844,P01889,Q13546,P11166,Q96A33,Q14108,Q15392,Q15067,P21964,P55263,Q13363,O76024,P09601,P54802,Q10713,O75431,O14936,Q8N511,Q96EY8,P53634,O95202,Q86Y39,P22626,P28070,Q6NUQ1,Q96J02,P40939,P04062,P16930,P31751,O43676,Q8N1F7,Q8NFH4,Q9BT22,Q9NVI7,Q9UBM7,Q14739,Q9NZJ7,O43772,P06737,P07602,O43681,Q16836,O75381,Q9H267 57 +Neonatal onset 0.4045576068820666 0.7577253294121233 0.4486154321873052 1.0 0.7244522345340149 16 P40939,Q96EY8,Q13546 3 +Spastic paraparesis 0.3890977925713194 0.7568438734625953 0.4491434044123152 1.0 0.7244522345340149 19 Q13057,P21912,Q8N0X7,Q9H6K4,P04062 5 +Urinary incontinence 0.3368279143096562 0.7568335240124349 0.4491496055925421 1.0 0.7244522345340149 38 P11166,O75298,P35637,Q99720,O60488,Q9NZJ7,P07196,Q8TAA9,P07602,O43681 10 +Focal dystonia 0.3860189109940657 0.756530505123021 0.4493311898827938 1.0 0.7244522345340149 20 Q9NQZ5,P35637,Q99720 3 +Bowing of the arm 0.5792169062838922 0.7551539736820514 0.4501566013694054 1.0 0.7250050899582811 5 Q32P28,P16435 2 +Abnormality of carpal bone ossification 0.5790914642158802 0.7546386409425415 0.4504658319497632 1.0 0.725056292647998 5 Q15125 1 +Limitation of movement at ankles 0.5750996149813457 0.7499225210962114 0.4533013697057737 1.0 0.7284173440142762 4 O75844 1 +Tissue ischemia 0.3932144722082575 0.7491242985381076 0.4537822908994742 1.0 0.7286493458164007 17 P01889,O75844,P05067,P78347 4 +Abnormal blood transition element cation concentration 0.4753558331133144 0.7479499119215742 0.4544903701228993 1.0 0.7293449104682299 11 P28288,O43819,Q9Y276,Q6PGP7,Q9Y487,Q15904 6 +Limited elbow extension 0.5071472038858729 0.747866826246118 0.4545404889883331 1.0 0.7293449104682299 9 Q96L58,Q9H6K4,P16435 3 +Abnormality of the ulna 0.3693185386622317 0.7446667876775719 0.4564731817563932 1.0 0.7319227008655564 25 O95202,Q96L58,P16435,P25054,Q13363,P36507 6 +Blue sclerae 0.3869538398854621 0.7413300338223202 0.4584933555721544 1.0 0.7342585617887092 19 Q96EK5,Q8NCH0,Q96L58,P62266 4 +Abnormality of the posterior pituitary 0.5726028613388475 0.7397676439529226 0.4594409951194464 1.0 0.7346547757586216 4 O76024 1 +Macule 0.3229251257542722 0.7394227793461263 0.459650314244699 1.0 0.7346547757586216 50 Q06136,O75844,Q7LGA3,P21912,P25054,P16615,Q15233 7 +Abnormality of the calf musculature 0.4521516705584928 0.738550263631069 0.4601801350037771 1.0 0.7349780946252497 12 P50570,P02545,Q9NRG9,Q9NR77,P43243,O60231,Q9Y5P6 7 +Deviation of the hallux 0.3766207110184019 0.7375140242362606 0.4608098179145461 1.0 0.7355052614950311 22 P78347,Q96L58,Q7LGA3,Q96J02,P04062,Q15233 6 +Decreased circulating iga level 0.5202580932057449 0.7372926290714505 0.460944413685078 1.0 0.7355052614950311 8 P13051,Q13724,P50851,Q96J02,P00813,Q15904 6 +Distal upper limb amyotrophy 0.4303466750780054 0.7363568693624943 0.4615135454598755 1.0 0.7356167114905909 13 Q8TB36,Q15120,P43243,Q9NR77,P31483 5 +Abnormal circulating aromatic amino acid concentration 0.5742066878326609 0.7346159496654722 0.4625734215394073 1.0 0.736425768527917 5 Q9UJS0,P16930,P35270 3 +Hyperpigmentation of the skin 0.3032070579248427 0.7338419951353361 0.463045042526311 1.0 0.736425768527917 72 P36551,Q14739,Q06136,O75844,P21912,Q7LGA3,P04062,P16615,P51648 9 +Coxa valga 0.4193712352080313 0.7333006879718158 0.4633750555346116 1.0 0.736425768527917 14 Q9Y619,Q96A33,O75844,Q96L58,P02545 5 +Focal cortical dysplasia 0.4524158125915077 0.7332863930345914 0.4633837723535734 1.0 0.736425768527917 2 P42345 1 +Abnormality of pulmonary circulation 0.3759667886856733 0.7324972091038358 0.4638651455530791 1.0 0.7364935941048748 22 O75844,P04062,O96000,Q14108 4 +Multicystic kidney dysplasia 0.3907776740886846 0.7321404253900923 0.4640828618824835 1.0 0.7364935941048748 17 Q10713,O75381,Q9UBM7,P50542 4 +Ulnar deviation of finger 0.5338639476798255 0.7314835339527418 0.4644838585099995 1.0 0.7368694086224382 7 Q96L58 1 +Narrow vertebral interpedicular distance 0.5104357378249724 0.7290328543660107 0.4659815656778725 1.0 0.7382962191323769 3 Q14807,Q96HY6 2 +Vertebral arch anomaly 0.5104357378249724 0.7290328543660107 0.4659815656778725 1.0 0.7382962191323769 3 Q14807,Q96HY6 2 +Impaired vibration sensation in the lower limbs 0.4285477072016675 0.7256024064141521 0.4680825454614408 1.0 0.7410068656193813 13 Q9NR77,Q15120,Q9H0B6 3 +Type ii transferrin isoform profile 0.450585651537332 0.7241815752823272 0.4689542684429795 1.0 0.7418635025633036 2 Q15904 1 +Gray matter heterotopia 0.3746297258301652 0.7222466546033288 0.4701428439983051 1.0 0.7426755003652069 22 Q9UBM7,Q9BSJ2,P35606,P61978,Q86XL3 5 +Abnormality of globe size 0.32104383370495 0.7214063281637436 0.4706595542761058 1.0 0.7426755003652069 49 P11166,Q15125,O14936,Q9BUK6,P21964,Q9Y5P6,O43924,O75431,Q9UHX1 9 +Abnormal conus terminalis morphology 0.5315859313775886 0.7212298698446696 0.4707680969542605 1.0 0.7426755003652069 7 Q13363 1 +Hepatic encephalopathy 0.5084450175295836 0.7201581289733587 0.4714276406935476 1.0 0.7431567444442014 3 Q6NUQ1 1 +Acetabular dysplasia 0.516325302368132 0.7188342948227601 0.4722430242936002 1.0 0.7437051540938812 8 P08236 1 +Dysmetria 0.3220035956432651 0.7166150392287172 0.4736116622059092 1.0 0.7447684442817522 47 O14773,Q6P4A7,Q9BUK6,P78347,Q5JRX3,O75027,Q8N0X7,P41440,Q10713,Q8IV08,O60313,O75503 12 +Thoracolumbar kyphosis 0.5694225435999885 0.7150938832449405 0.4745510333314111 1.0 0.7457230523779318 5 P08236 1 +Pulmonary hypoplasia 0.3655330440132728 0.7140588904011518 0.4751907649296711 1.0 0.7462057918139833 25 Q9UBM7,Q14739,O75844,Q96L58,P98175,P02545,Q8TAA9,O96000,Q5JTZ9,Q99567 10 +Thoracic hypoplasia 0.3705792067979294 0.7128039232810515 0.475967097564214 1.0 0.7467543274072794 23 Q96A33,O75718,Q14739,P16435,P02545,P04062,Q9UHX1,Q9UM00 8 +Scaphocephaly 0.506765492461094 0.7126873519171427 0.4760392448111021 1.0 0.7467543274072794 3 P40855 1 +Periauricular skin pits 0.4841110646825719 0.7104201454369431 0.4774436342161623 1.0 0.7484341705770647 10 Q13363,P61978 2 +Aplasia hypoplasia of the uterus 0.3973436694596616 0.7094136161756902 0.4780678405360281 1.0 0.7490258594931292 16 P11766,O95202,Q9NX14,O96028,Q9Y5S9,Q13363,Q9UNW1,P53701,P57740 9 +Osteolysis involving bones of the upper limbs 0.5288033815834089 0.7087354406517162 0.4784886673722819 1.0 0.7490258594931292 7 O75844,O75431 2 +Distal muscle weakness 0.3183586619143743 0.7078887278189051 0.4790143602843735 1.0 0.7493669891120663 57 P36551,Q8TD16,Q8TB36,P35637,P40939,Q99720,P22626,P07196,P41440,O15269,P46976,Q9NR77,P43243,P09651,Q9Y5P6,P31483 16 +Hand muscle weakness 0.4835475872257242 0.7075451755736076 0.479227749158245 1.0 0.7493669891120663 10 Q8TD16,Q9NR77,Q15120,P31483 4 +Abnormal iris pigmentation 0.4062905988565941 0.7068943262535655 0.479632150136706 1.0 0.7494641614059824 15 P50542,O75381,Q05086,P78347 4 +Lower limb hypertonia 0.4833749637900125 0.7066647232250551 0.4797748568906017 1.0 0.7494641614059824 10 Q14739 1 +Increased susceptibility to fractures 0.3236598135676642 0.7048015781178563 0.4809337263342894 1.0 0.7496791313351991 44 Q13126,Q32P28,Q14108,P22626,Q14739,Q96L58,P16435 7 +Decreased specific antibody response to vaccination 0.5639156712610414 0.7046309604671726 0.4810399260284264 1.0 0.7496791313351991 4 P17812,Q13546 2 +Abnormal glycosylation 0.3843385804205314 0.7035912146326931 0.4816873840663518 1.0 0.7496791313351991 18 Q8N511,Q9Y487 2 +Abnormality of bladder morphology 0.5130432707403062 0.7034823090763005 0.4817552278464685 1.0 0.7496791313351991 8 Q9NWM8 1 +Renal hypoplasia 0.3692390390087067 0.7023543920918685 0.4824581803666938 1.0 0.7496791313351991 23 O75312,Q9UBM7,P21964,O43924,Q9UHX1 5 +Neonatal death 0.4055239488610474 0.7019674429155622 0.4826994673492859 1.0 0.7496791313351991 15 Q9NVI7,Q14739,Q9H0R6,O96000,P04062 5 +Tooth malposition 0.2961399796908356 0.7014713884470964 0.4830088841721278 1.0 0.7496791313351991 75 Q96A33,Q9UBM7,Q14739,O75844,Q9BSJ2,Q8N0X7,P08236,Q01105,O75431,Q05086,Q15233 11 +Abnormal forearm bone morphology 0.4244880351008342 0.7013932929215972 0.4830576065167273 1.0 0.7496791313351991 13 Q96L58,Q32P28,P16435,P25054 4 +Shallow orbits 0.4974756685797448 0.7005278734910275 0.4835977042129471 1.0 0.7496791313351991 9 O75844,O75431 2 +Chordee 0.5267357181326128 0.6994733438375278 0.4842562659811089 1.0 0.7502043913438788 7 P48651,P16435,Q9NX14 3 +Hypoplastic fingernail 0.4451259377162988 0.6988908717655221 0.4846202325680955 1.0 0.7503228766115082 12 O75431,Q14739 2 +Anteverted ears 0.4454612005856539 0.6988158583858786 0.4846671165991003 1.0 0.7503228766115082 2 P27635 1 +Epispadias 0.5648297869144494 0.6964401186688829 0.4861532459222939 1.0 0.7513277436980905 5 Q9Y619,P48651,Q9NX14 3 +Abnormal urine protein level 0.3200135091772036 0.6951671667758751 0.4869505459589658 1.0 0.752300877887724 47 Q8NFH4,Q14108,O95470,P78347,O60488,P21912,P09601,P06737,O75431,P04062,Q02978,Q8N1F7 12 +Missing ribs 0.496037081052657 0.6935231913806814 0.4879812770064009 1.0 0.7528369992510506 9 Q8TAA9,Q14739 2 +Limited wrist movement 0.561099123132467 0.6933083822029976 0.4881160438240146 1.0 0.7528369992510506 4 O75844 1 +Redundant neck skin 0.5393013505319322 0.6925731772842835 0.4885774480177531 1.0 0.7528959524751901 6 Q9Y487 1 +Abnormal retinal vascular morphology 0.3254435727563587 0.6924133454178376 0.4886777873351668 1.0 0.7528959524751901 42 P21964,P21912,Q9NZJ7,O75306,P07602,Q02978 6 +Lewy bodies 0.5391819090052647 0.6920609374136822 0.4888990614168551 1.0 0.7529783759913679 6 P04062 1 +Abnormal renal cortex morphology 0.3202237334425326 0.6911791991526 0.4894529340337212 1.0 0.7534216039113998 46 Q8NFH4,Q14108,O95470,Q8N1F7,P21912,O60488,Q92621,P02545,P57740,O60231,P01889,P00813,P16930,Q02978,Q14C86,O75431 16 +Abnormality of the outer ear 0.2704761161164294 0.6908012218847203 0.4896904676046241 1.0 0.7534216039113998 280 Q9HC07,P36551,Q8IWS0,P37268,Q8NCH0,Q9H9C1,P98175,P23786,P25054,O43924,Q96EK5,P61978,Q9Y487,Q9UHX1,P11166,Q96A33,Q15392,Q15067,Q9NX14,Q06136,P21964,P16435,Q13363,O76024,P42892,Q10713,P36507,O14936,Q13153,Q9UM00,P49366,Q15125,Q8TD16,O95202,Q16625,Q96L58,Q7LGA3,P48651,P38159,Q92917,Q96J02,P50542,P04062,Q92643,Q13555,Q9UBM7,Q14739,O75844,P62266,Q9BSJ2,Q8N0X7,P48449,Q01105,O75381,Q9H267 55 +Hiatus hernia 0.5096783365215772 0.6877945262015157 0.4915821836282865 1.0 0.7548363918416297 8 Q8NCH0,Q8NBU5 2 +Abnormality of prothrombin 0.4429992679284462 0.6869359968296151 0.4921230617783727 1.0 0.7548363918416297 12 P40939,P38435,Q6NUQ1,Q16836 4 +Abnormal odontoid tissue morphology 0.3315481968884909 0.68672463854535 0.4922562675951791 1.0 0.7548363918416297 36 Q9HC07,Q9NX14,Q9UBM7,P21964,Q96L58,P48651,P25054,P51648 8 +Abnormality of the musculature of the thigh 0.5093609523214835 0.6863176535495422 0.4925128190687449 1.0 0.7548363918416297 8 P50402,O14979,P07196 3 +Synovitis 0.4428989751098235 0.6862069627358859 0.4925826077279804 1.0 0.7548363918416297 2 Q02750 1 +Aplasia hypoplasia involving the vertebral column 0.411765777871714 0.6861345020249253 0.4926282958342542 1.0 0.7548363918416297 14 Q8TAA9,P08236,Q14739 3 +Delayed closure of the anterior fontanelle 0.4426586460421828 0.6850235245346702 0.4933290764345499 1.0 0.7556521826069147 12 Q9Y487 1 +Back pain 0.3787471007406632 0.6821744132499516 0.4951286717372267 1.0 0.7576329624127766 19 P36551,P01889,Q8TAA9 3 +Aplastic clavicle 0.4994519383738159 0.6803419333523303 0.4962879787314618 1.0 0.7583726416570652 3 P48651 1 +Joint dislocation 0.2960920675390892 0.679894439349759 0.496571302812385 1.0 0.7584791240090323 74 Q8TD16,Q96A33,Q15125,O95202,Q8NBU5,Q9UBM7,P21964,Q8NCH0,Q96L58,O75844,P25054,Q13363,Q9Y487,Q9Y5P6 14 +Generalized myoclonic seizure 0.3383010426693256 0.6796980591276998 0.4966956652100147 1.0 0.7584791240090323 33 Q96N66,P21912,Q9NZJ7,Q01105,P07602,P04062 6 +Specific learning disability 0.3180565481790885 0.6790972792954652 0.4970762262460415 1.0 0.7588020759837533 54 P11166,P35637,Q9NX14,P09651,P21964,P22626,P48651,P62266,P25054,O75845,P00367,Q8N0X7,Q9H6K4,Q10713,P36507,Q96EK5 16 +Congenital nonbullous ichthyosiform erythroderma 0.5568385828464356 0.6762497937566682 0.4988820630567199 1.0 0.7600077050232719 4 P04062,P19447 2 +Microretrognathia 0.419762028573608 0.6733246836603295 0.5007407525467906 1.0 0.761546762937986 13 Q15125,Q16625,Q8NCH0,P41227,P53007,Q9UHX1 6 +Rhabdomyolysis 0.4404335131977084 0.6725463285955107 0.5012359568134781 1.0 0.7620416579196782 12 P23786 1 +Hyperconvex fingernails 0.5344464271103109 0.6718062716801809 0.5017070355465041 1.0 0.762099639364558 6 Q13363,O95202 2 +Oval face 0.5205054453668451 0.6716861517907727 0.5017835192340172 1.0 0.762099639364558 7 Q96L58,O14936 2 +Bulbar palsy 0.4609524235721171 0.67101931020802 0.5022082280957885 1.0 0.7622151657934756 11 O43681,P35637,P43243 3 +Joint laxity 0.3105048582921765 0.6692159628831257 0.5033577249311698 1.0 0.7629413946271834 62 Q9HC07,Q32P28,Q96A33,Q9BUK6,Q8NCH0,Q96L58,P55795,Q9Y487,Q15233 9 +Decreased mean corpuscular volume 0.4392386530014781 0.6682845296978356 0.5039519865396964 1.0 0.7634308912233194 2 Q86SX6 1 +Abnormality of female external genitalia 0.3337621442313339 0.6680302307508392 0.5041142955574316 1.0 0.7634308912233194 34 Q9Y619,Q15392,Q9NX14,Q9UBM7,P16435,P40855,P50542,P51809,O75381 9 +Occipital encephalocele 0.5544045277139344 0.6665428480108657 0.5050641856040019 1.0 0.7637907774893093 4 Q10713 1 +Ptosis 0.2744631655203619 0.6662057563230867 0.5052795941100177 1.0 0.7637907774893093 184 Q8IWS0,O75306,P25054,P07196,O75845,O96000,Q9Y6M9,Q7KZN9,P01889,P61978,Q96EK5,Q86XL3,Q9UHX1,Q96A33,P35637,O95470,Q9NX14,P21964,Q13363,O76024,Q10713,P36507,Q9UM00,Q15125,O95202,Q86Y39,P50570,Q7LGA3,Q9P0J0,Q96J02,P04062,O60313,O43676,Q9UBM7,Q9NZJ7,P07602,O75381,Q9Y5P6,P50402 39 +Agenesis of corpus callosum 0.306969795481292 0.6653300525561942 0.5058394128464403 1.0 0.7639466751173531 65 O95202,Q15392,Q7LGA3,P48651,P23786,Q13363,P35606,Q9Y5P6,Q10713,P61978,Q86XL3,Q9UHX1 12 +Limb muscle weakness 0.3007309829891915 0.6650594988901178 0.5060124380164472 1.0 0.7639466751173531 70 P36551,Q8TB36,P07196,P46976,Q9NR77,Q16637,Q15067,Q96BR5,P02545,P05023,O75298,Q99720,P50570,Q15120,P40939,Q13126,Q14739,Q8N0X7,O15269,Q9Y5P6,P50402,P31483 22 +Short palpebral fissure 0.3671234963124026 0.6649025747240315 0.5061128088263762 1.0 0.7639466751173531 22 Q9Y619,Q9NXE4,O75844,P98175,P02545,O60701,P55795,Q9UHX1 8 +Abnormal sclera morphology 0.3643990287710354 0.6647133926404518 0.5062338261584243 1.0 0.7639466751173531 23 P40939,P62266,Q8NCH0,Q96L58,Q96EK5 5 +Oligohydramnios 0.3611686593053148 0.662556487198225 0.507614645986314 1.0 0.7652440369860181 24 Q96L58,Q7LGA3,P16435,P23786,Q9Y5P6,Q9UHX1 6 +Abnormality of cranial sutures 0.2962843977915402 0.6624845896902003 0.507660707765468 1.0 0.7652440369860181 73 Q32P28,Q9UM00,P21964,Q8NCH0,P48651,Q96L58,O75844,P98175,P16435,P61978,Q9Y487,O75381,O75431 13 +Saccadic smooth pursuit 0.5533396662174439 0.6623053225183118 0.5077755664314532 1.0 0.7652440369860181 4 O14773,Q10713 2 +Cystic hygroma 0.5317822778589876 0.660459048322594 0.5089592899920383 1.0 0.7658235278416415 6 P61978,Q14739 2 +Reduced consciousness confusion 0.280377905828885 0.6592350511331575 0.5097448420384438 1.0 0.7665562520967543 105 P36551,Q9Y619,Q96CU9,O75306,P23786,O96000,Q9Y6M9,P01889,Q99567,P11166,Q9NX14,P00367,P05067,P46783,Q96EY8,P05166,Q86Y39,Q9HCC0,Q96IX5,P41227,P49770,Q9NR50,P40939,P04062,P31751,O43676,Q13144,Q9UBM7,Q13423,P35610,Q9NZJ7,O96008,O43772,P35270,O43819,P07602,O43681,Q16836 38 +Axonal degeneration 0.5555628865904613 0.6590839022006096 0.5098418922702344 1.0 0.7665562520967543 5 Q8TB36 1 +Apraxia 0.3157221972140404 0.6554242637330592 0.5121946337344978 1.0 0.7687280165747647 52 P11166,O14773,P35637,Q7LGA3,O96008,Q8N0X7,O43924,Q10713,P05067,P04062,Q05086,Q15233 12 +Abnormal circulating fatty acid anion concentration 0.4372882935351092 0.654959470693496 0.5124938488250272 1.0 0.7687407732375409 12 P40939,Q16836,O43772,P23786 4 +Acute hepatic failure 0.4371250686042723 0.6540484249614323 0.5130806077318688 1.0 0.7693637712999088 12 P40939,P16930,Q6NUQ1,Q96J02,P01889,Q16836 6 +Anencephaly 0.4164567965243919 0.6537741410980672 0.5132573287340876 1.0 0.7693717072005962 13 Q8TAA9 1 +Progressive spastic quadriplegia 0.5021186600158688 0.6527567788856036 0.5139130915958963 1.0 0.7700974808288422 8 P07602,Q9NZJ7 2 +Lymphopenia 0.3627971208941938 0.6522919597499222 0.514212845851298 1.0 0.7702894700202354 23 O95470,Q13432,P17812,P28070,Q13546 5 +Paraparesis 0.3577890923329484 0.6517294761304123 0.5145757038844074 1.0 0.7705758288399135 25 P35637,P21912,Q8N0X7,Q9H6K4,P04062 5 +Progressive 0.2860639115176496 0.6514356912883644 0.5147652773031033 1.0 0.7706025899053794 94 Q13057,P27544,P35606,Q9Y6M9,O95470,P28288,Q16637,P55263,P02545,P57740,P54802,Q5T440,O00429,O75298,Q99720,Q8NBU5,Q5JTZ9,Q9NRG9,P04062,O60313,Q8N1F7,Q13126,Q9H0B6,Q14671 24 +Bladder diverticulum 0.5294785226617955 0.6506758408933951 0.5152557616634601 1.0 0.771079645997202 6 Q9NWM8 1 +Abnormality of the spinal cord 0.3145131115022739 0.646753113590399 0.5177917417696247 1.0 0.7739362599612876 55 O75298,O95202,P21964,Q99707,Q96L58,P25054,O75845,P07196,Q8TAA9,Q13363,Q9Y5P6,Q10713,P05067,Q9UHX1 14 +Somatic sensory dysfunction 0.286755790996329 0.6466563038780792 0.5178544092388027 1.0 0.7739362599612876 92 Q8TB36,Q8NCH0,P07196,P41440,Q9NR77,Q8IV08,P01889,P61978,P11166,O14773,P54802,P05067,O75298,Q15120,Q9BUK6,Q9H0B6,Q9NZJ7,Q8N0X7,Q9H6K4,O15269,P43243,P07602 22 +Multifactorial inheritance 0.4711800412648099 0.6448571500158249 0.519019762385601 1.0 0.7747036078596716 10 P42892 1 +Abnormal thumb morphology 0.2894818516938685 0.6441269408840431 0.5194931216342284 1.0 0.7749211116389475 85 O95202,Q9UBM7,Q8NCH0,Q96L58,Q7LGA3,P25054,Q8N0X7,Q13363,Q9H6K4,P42892,Q86XL3,Q15233 12 +Abnormality of limb epiphysis morphology 0.3642660591514838 0.6431758699605652 0.5201099887918204 1.0 0.7750134547922923 22 O95202,Q96L58,Q7LGA3,P16435,Q13363 5 +Telecanthus 0.3373427245947976 0.6423878449938377 0.520621389857673 1.0 0.7751467725252155 32 Q15125,Q8NCH0,O75844,Q86XL3 4 +Uncombable hair 0.4337481698389425 0.6416111523438015 0.5211256900279579 1.0 0.775468201871842 2 Q6PGP7 1 +Delayed ability to walk 0.3090258722027261 0.6400032978496021 0.5221704553750692 1.0 0.7758462614286782 61 O14936,P35637,Q96N66,Q99720,P21912,P48449,Q01105,P61978,Q05086,Q15233 10 +Episodic tachypnea 0.5133370225781131 0.639957321993897 0.5222003457832254 1.0 0.7758462614286782 7 O43924 1 +Tachycardia 0.3563163397411481 0.6399261091288047 0.5222206387893378 1.0 0.7758462614286782 25 P36551,Q9NX14,P21912,O43772,P23786,P09493,P02545,P42892,P46976 9 +Excessive salivation 0.3582236658322092 0.6392899536629512 0.5226343227892394 1.0 0.7758462614286782 24 Q8N0X7,Q9NR77,P55795,Q05086,Q15233 5 +Agnosia 0.5130523807338796 0.6387031443994717 0.523016066770047 1.0 0.7758462614286782 7 P05067 1 +Abnormality of the plantar skin of foot 0.3211543185908081 0.6355256057854991 0.5250856720648778 1.0 0.7769814952287266 41 P53634,Q06136,P42167,P21912,O95453,P09493,P02545,P36507,P61978,Q9Y487,P16615,O75431 12 +Decreased plasma carnitine 0.4542054651071174 0.6353672120946163 0.5251889471570439 1.0 0.7769814952287266 11 P40939,Q16836,O43772,P23786 4 +Squamous cell carcinoma 0.4541850891985015 0.6352599636289582 0.5252588806871561 1.0 0.7769814952287266 11 P02545,P53634,P14324,P19447 4 +Abnormality of the musculature of the limbs 0.2798648519364072 0.6313296426326674 0.5278250088436194 1.0 0.7805201448732005 129 P36551,Q8TB36,P21912,P07196,P46976,Q9NR77,Q9Y487,Q15067,Q16637,Q96BR5,P02545,P05023,P09651,Q5T440,P46783,P05166,O00429,Q15125,Q8TD16,P49366,O75298,Q99720,P50570,Q15120,Q9NRG9,P40939,O60313,Q13126,O14979,Q14739,Q9NZJ7,Q9BW92,P35270,O43819,Q8N0X7,O15269,P43243,O60231,P07602,Q9Y5P6,P50402,P31483 42 +Aplasia hypoplasia involving the skeletal musculature 0.4972771913134614 0.6304797457237834 0.5283807503786604 1.0 0.7810374696389615 8 Q9Y487 1 +Abnormality of the vasculature of the eye 0.3062401848146571 0.6302624222566627 0.5285229044771671 1.0 0.7810374696389615 63 Q14739,P21964,P21912,Q9NZJ7,O75306,P07602,P28070,P01889,Q02978 9 +Hypoventilation 0.4819392445400896 0.6254570863162014 0.5316711051785321 1.0 0.7833683256865568 9 O75306 1 +Limited hip movement 0.4115229070375747 0.6247241744774057 0.5321521040412893 1.0 0.7838197055915019 13 O75844,Q7LGA3 2 +Abnormality of the scrotum 0.3255914095754431 0.6227324240647218 0.5334603717563118 1.0 0.7847165350515658 35 Q8IWS0,Q9UBM7,Q7LGA3,P16435,P46977,P51809,Q9UM00 7 +Cholecystitis 0.4950807148781952 0.6204179044398913 0.5349826877092274 1.0 0.7866980021097683 8 P07602,Q9NZJ7 2 +Abnormal aortic arch morphology 0.5087613415679412 0.6198517490770299 0.5353553950754162 1.0 0.7869882126100451 7 P21964 1 +Hyperactive deep tendon reflexes 0.494631124384657 0.618361944536796 0.5363367774418464 1.0 0.787998675322281 8 P21912,Q9NR77 2 +Distal arthrogryposis 0.5421466638096967 0.6181189618276312 0.5364969238266473 1.0 0.787998675322281 4 Q8NCH0,Q96A33 2 +Diplopia 0.3721574183888703 0.6179886330227379 0.536582831566184 1.0 0.787998675322281 18 P11166,O14773,P04062,Q14671,P19447,P01889,P53007 7 +Ventricular escape rhythm 0.5451848884984899 0.6177425073828448 0.5367450870009387 1.0 0.787998675322281 5 P02545,P50402 2 +Infantile axial hypotonia 0.5078705476330447 0.6159517037423553 0.5379263956741336 1.0 0.7889587136553959 7 Q9NZJ7 1 +Abnormality of the fontanelles or cranial sutures 0.2866273665064041 0.6139390982940097 0.539255572396617 1.0 0.788969040528977 87 Q15125,Q32P28,Q9BT22,P61978,O75844,Q8NCH0,P21964,Q96L58,P48651,P16435,P98175,O75431,Q9Y487,O75381,Q9UM00 15 +Abnormality of the synovia 0.297917870691546 0.6125829108991284 0.5401521606455928 1.0 0.7893855086217585 69 Q8TD16,Q96A33,O95202,Q8NBU5,Q9UBM7,O75844,Q96L58,P16435,P25054,Q13363,P08236,Q6NUQ1,Q9Y487,Q9Y5P6 14 +Abnormal erythrocyte sedimentation rate 0.5203525040279853 0.6122018227063127 0.5404042357971861 1.0 0.7894968132349516 6 P28070 1 +Abnormal left ventricle morphology 0.3547359780334848 0.6118290817917424 0.5406508464444695 1.0 0.7896000647064039 24 O75431,P21912,Q15233 3 +Cerebral calcification 0.343116469516568 0.6113955181676332 0.54093776901595 1.0 0.7897621038853558 29 O00429,P11166,P53634,Q16625,P23786,O75845,P19447,P05067,O60313,O95453 10 +Gastroesophageal reflux 0.2816027113460829 0.6099148324495469 0.5419182265174469 1.0 0.7901653673197861 97 Q9UHX1,Q96A33,P21964,P16435,Q13363,P55795,Q13153,Q86TI2,O95202,Q8NBU5,Q8IZA0,Q96J02,Q9UBM7,Q14739,P78347,Q9NZJ7,O15269,Q01105,P07602,Q15233 20 +Hyperinsulinemic hypoglycemia 0.5184999203892119 0.6044494485644557 0.5455448685099049 1.0 0.7931342306033214 6 P00367,Q16836 2 +Areflexia of lower limbs 0.3700725901402992 0.6034510070011271 0.546208698653448 1.0 0.793328362316076 18 Q15067,Q16637,Q15120,P07196,Q9H6K4,Q9NR77,O60313 7 +Blindness 0.297038514023659 0.601469993836499 0.5475269915363135 1.0 0.7947286992286464 69 P50897,Q96CU9,P21912,O75306,O96000,Q9Y6M9,P01889,P06865,P61960,Q9NX14,Q99707,Q86Y39,P41227,P49770,Q9NR50,O43676,Q13144,Q9NZJ7,Q9H6K4,P07602,Q9Y5P6 21 +Visual field defect 0.3182060877271634 0.5943804046744996 0.5522577115922389 1.0 0.7994569118726824 40 Q9H061,O75306,Q9H6K4,P01889,O75381,Q8WWV3 6 +Alopecia 0.3192164708659261 0.5939219097844066 0.5525643441006849 1.0 0.7994569118726824 39 Q06136,O75431,O75844,Q15125 4 +Abnormal brain lactate level by mrs 0.4891620379369357 0.5934528435022175 0.5528781329721588 1.0 0.7994569118726824 8 O75306 1 +Abnormal morphology of the conjunctival vasculature 0.515805282044528 0.5932102168974673 0.5530404759345098 1.0 0.7994569118726824 6 P18074,P19447,P04066 3 +Ectopic kidney 0.4461381534318795 0.5931209616281697 0.5531002030669963 1.0 0.7994569118726824 11 Q8TAA9,Q9UHX1,P25054 3 +Weakness of muscles of respiration 0.3348788225430039 0.5912833559112162 0.5543305797158133 1.0 0.8004619181996687 31 P36551,Q8TD16,Q15067,P22626,P50570,Q9Y5L0,P02545,P43243,Q9BTV4,P09651,Q9BQP7,P53007,P50402 13 +Abnormal scrotal rugation 0.422401171303069 0.5873629547705214 0.556959968240492 1.0 0.8032250441720207 2 Q9UNW1 1 +Status epilepticus 0.3193790921490405 0.586129025470759 0.5577888123463115 1.0 0.8039037218401561 38 Q15392,Q9NZJ7,P42892,Q01105,P07602,Q9Y487 6 +Absent septum pellucidum 0.3447582943642819 0.5822136121598883 0.5604228056384699 1.0 0.8066955018773996 27 Q9NZ01,O95202,Q15392,Q9NX14,Q96N66,P48651,Q13409,Q13363,P53701,P51571 10 +Focal tonic seizure 0.4213030746705683 0.5821808519509517 0.5604448696198154 1.0 0.8066955018773996 2 Q9H936 1 +Abnormality of the musculature of the upper limbs 0.3009663160440036 0.5791136319360852 0.5625125024579785 1.0 0.8079205757362059 64 P36551,Q8TD16,Q8TB36,O14979,Q9NZJ7,Q15120,P07196,O60313,Q9NR77,P43243,P07602,Q9Y487,Q9Y5P6,P50402,P31483 15 +Abnormal clavicle morphology 0.3685689777807619 0.5790893500602095 0.5625288857101212 1.0 0.8079205757362059 17 O75431,Q14739 2 +Peripheral axonal neuropathy 0.3094132384876184 0.5763448005455404 0.5643821468748924 1.0 0.8091062210133253 46 Q13057,Q9NVI7,Q15067,P22626,Q9H0B6,Q9NZJ7,P07196,O76024,O15269,Q8IV08,P09651,O60313,P07602 13 +Progressive spasticity 0.3857467553207999 0.5762246229631123 0.5644633640803747 1.0 0.8091062210133253 15 P07602,O43681,Q9NZJ7 3 +Type 2 muscle fiber atrophy 0.4738191138777003 0.5697560525277668 0.5688431666329037 1.0 0.8133061904582579 3 Q9NP81,Q8TCS8 2 +Dyspnea 0.2834320270958201 0.568737510475181 0.5695342878233722 1.0 0.8140349948252531 87 P01889,P35637,Q9NX14,O75844,Q15165,Q9NZJ7,Q96L58,O75306,P23786,P46976,P43243,Q86TI2,Q92804,P07602,P04062,Q96EY8,Q9UHX1 17 +Intracranial hemorrhage 0.357333903765714 0.5676041948432454 0.5703037581226795 1.0 0.8142761410565493 21 O75844,P23786,P05067,P04062,Q02978 5 +Impaired social interactions 0.3153686281966347 0.5663069967890311 0.5711851048859651 1.0 0.8142761410565493 40 P11166,Q86Y39,Q15067,Q9NX14,O75306,O96000,Q9Y6M9,Q9UHX1,O43676 9 +Premature loss of teeth 0.455415616201985 0.5663002477005467 0.5711896920694115 1.0 0.8142761410565493 10 O75844,P53634 2 +Hypotension 0.3516281081987013 0.566295876446931 0.5711926631084503 1.0 0.8142761410565493 23 Q13423,Q9NZJ7,O43772,P07602,O43681,P04062 6 +Abnormality of the upper arm 0.3665485690049363 0.5653627715073143 0.5718270410383315 1.0 0.8144588258267317 17 O14979,O00116,P48651,P16435,P02545,Q9BTV4,P50542,P50402 8 +Myoglobinuria 0.4690859223215905 0.5644586419842488 0.5724420391508478 1.0 0.8145383794156675 9 Q16836,P23786 2 +Abnormality of glycolipid metabolism 0.4959860959595746 0.5643935866373243 0.5724863025719276 1.0 0.8145383794156675 7 P07602,Q9NZJ7 2 +Entropion 0.4690587642944868 0.5643309732886026 0.5725289060012031 1.0 0.8145383794156675 9 P01889,P02545,P19447,O75844 4 +Failure to thrive in infancy 0.3400543772521517 0.5634135056158591 0.5731533427349995 1.0 0.8145383794156675 28 Q9HCC0,P37268,P35606,P42892,P36507,P40939,P06737,Q96J02 8 +Leukoencephalopathy 0.2847241786191698 0.562219463609326 0.5739665019150282 1.0 0.8147208417768957 81 Q96CU9,O75306,Q96TA2,O96000,Q9Y6M9,P27635,P18074,Q9UHX1,Q9NX14,Q96BR5,Q13363,Q13153,O75503,O00429,O95202,Q86Y39,P49770,Q5JTZ9,Q9NR50,O60313,O43676,Q13144,Q9NZJ7,P51571,P19447,Q01105,P07602,O43681,Q9Y5P6 29 +Hyperkeratosis 0.3069740737017536 0.5617539199616507 0.574283691602393 1.0 0.8148546341800632 55 P53634,Q06136,P04066,P21912,O75844,Q9NWM8,O75352,P42167,P09493,P02545,O15269,P36507,O75431,P04062,P16615,P51648,O95453 17 +Nasal speech 0.3463414924279707 0.5605052087829646 0.5751348877988898 1.0 0.8150953590762531 25 P21964,Q7LGA3,Q13409,Q9UPP1,P43243,Q9BQP7,Q9Y487,Q15233 8 +Sepsis 0.3746516120174612 0.5596500049086867 0.5757181897936603 1.0 0.8156007688743521 16 P01889,Q9BT22,P42892,P25054 4 +Premature birth 0.3156536061983873 0.55906555051145 0.5761169845277359 1.0 0.8157327135289172 39 P49366,Q9NX14,Q9UBM7,O75844,Q9H0R6,P02545,P40855,P36507,P50542,P04062,O75381,O43676 12 +Midface retrusion 0.2896867654223432 0.5578149653455673 0.576970742454203 1.0 0.8157327135289172 72 Q9HC07,Q8TD16,Q96A33,Q15125,Q9NX14,Q14739,Q96L58,P16435,Q9BSJ2,P55795,Q96J02,Q9Y487,Q9UM00 13 +Upslanted palpebral fissure 0.2959361041472402 0.5575868310736711 0.577126550981983 1.0 0.8157327135289172 67 Q15125,Q9UBM7,P21964,Q7LGA3,Q9BSJ2,P35606,O75381,Q86XL3,Q15233,Q9UM00 10 +Decreased circulating progesterone 0.5070114279249635 0.5568514712905673 0.5776289134569739 1.0 0.8157327135289172 6 Q9NR50,P49770,P16435 3 +Abnormal circulating progesterone level 0.5070114279249635 0.5568514712905673 0.5776289134569739 1.0 0.8157327135289172 6 Q9NR50,P49770,P16435 3 +Benign neoplasm of the central nervous system 0.3649855759944367 0.5547714395350405 0.5790510047026531 1.0 0.8172267009765747 17 Q02978,O43924 2 +Nemaline bodies 0.5254788682547776 0.5536593584222117 0.5798119942883635 1.0 0.8177630266263192 4 O43676 1 +Gowers sign 0.4181772368886421 0.5495617897294413 0.5826199728291686 1.0 0.8187079522085783 12 Q8TD16,Q9Y5P6,Q9BUK6 3 +Decreased adipose tissue 0.3892778432328971 0.5489349732097112 0.5830500762139219 1.0 0.8187079522085783 14 O75431 1 +Renal cortical microcysts 0.4139824304538761 0.547964791421082 0.583716078729797 1.0 0.8187079522085783 2 Q6PGP7 1 +Rib fusion 0.4654436063409578 0.5473856255640749 0.5841138286479206 1.0 0.8187079522085783 9 Q13363,Q9UM00 2 +Slurred speech 0.4782833691070817 0.544502978341815 0.5860953994414684 1.0 0.8207164282974446 8 Q9Y487 1 +Cerebral hypoplasia 0.4171620666592744 0.5440438457667726 0.5864113010723702 1.0 0.8209026572716148 12 P35606,Q86XL3,Q9UBM7 3 +Tonic seizure 0.3567970406615925 0.5436484042813872 0.5866834439365034 1.0 0.8209309449614274 20 P07602,O14936,Q9NZJ7 3 +Aplasia hypoplasia affecting the anterior segment of the eye 0.3591925401340856 0.5432172093689953 0.5869802589975981 1.0 0.8209309449614274 19 Q13363,P21912,Q02978,Q7LGA3 4 +Blue irides 0.4906283131552855 0.5414609295420858 0.5881899204883463 1.0 0.8223664682715571 7 Q05086 1 +Irregular hyperpigmentation 0.3054420427890739 0.5395989015699072 0.5894736743003546 1.0 0.8233917990227174 53 Q14739,Q06136,O75844,Q7LGA3,P21912,P16615 6 +Ovoid vertebral bodies 0.4896619151281276 0.5373466141523975 0.5910282122633892 1.0 0.82530635240762 7 Q96L58 1 +Abnormal circulating androgen level 0.4631360481408513 0.5366220045067513 0.591528741317684 1.0 0.8255767049333919 9 P51809,P16435 2 +Abnormality of the breast 0.2828404856507895 0.5364334231174814 0.5916590371293022 1.0 0.8255767049333919 81 Q96A33,Q15067,Q9UBM7,Q7LGA3,P21912,P23786,P25054,Q13363,P61978,P51809,P31751,Q15233,Q9UM00 13 +Hypersplenism 0.4888859516953708 0.5340480777310991 0.5933082713601834 1.0 0.8255767049333919 7 P07602,P04062,Q9NZJ7,Q14108 4 +Curly hair 0.4487918629787538 0.5338323240502384 0.5934575478118984 1.0 0.8255767049333919 10 Q96A33 1 +Anisocoria 0.5201718899699842 0.5335133774123001 0.5936782532819846 1.0 0.8255767049333919 4 Q9NR77 1 +Atrioventricular canal defect 0.5012567115182434 0.533341581304034 0.5937971487355145 1.0 0.8255767049333919 6 Q9UBM7 1 +Encephalopathy 0.2801511908874596 0.5327113071007775 0.5942334377968366 1.0 0.8257770115832918 89 Q9H845,O75306,P23786,O96000,Q9Y6M9,Q7KZN9,P11166,Q15067,Q86Y39,Q8NBU5,Q6NUQ1,P40939,P04062,O43676,Q9NVI7,Q9NZJ7,O43772,P07602,Q16836 19 +Tongue atrophy 0.4645254856026493 0.530923961418083 0.5954714725109378 1.0 0.8271358615379414 3 P07196 1 +Abnormality of metacarpophalangeal joint 0.519205251737803 0.5298650917531899 0.596205470802571 1.0 0.8278991809906989 4 P16435 1 +Perseveration 0.487659215557061 0.5288425974835195 0.5969146449733111 1.0 0.8280138853536146 7 P35637 1 +Severe muscular hypotonia 0.3422680418875716 0.528376876126089 0.5972377837964145 1.0 0.8280138853536146 25 Q8TD16,Q9NWM8,P02545,Q01105,P40855,P50542,Q5T440,O75381 8 +Slowly progressive 0.3044047943403403 0.528150266457538 0.5973950447359635 1.0 0.8280138853536146 53 O14773,Q16637,Q99720,O14979,P50570,Q96BR5,Q9P0J0,Q15120,P07196,P41440,P02545,P46976,Q9NR77,Q8IV08,P05023,Q5T440,P50402,P31483 18 +Sensory neuropathy 0.335668297689917 0.5270974042864055 0.5981259492081112 1.0 0.8287709972355676 28 P40939,Q15067,P22626,Q9H0B6,O15269,Q8IV08,O60231,P09651,Q5T440,O60313 10 +Oral ulcer 0.4869431323497294 0.5258092887079896 0.5990207200758477 1.0 0.8297546270680262 7 P01889 1 +Achilles tendon contracture 0.4322090897493009 0.5213292594472102 0.6021374215594291 1.0 0.8317461927052915 11 Q8TD16,P02545,O60313,Q08J23,P50402 5 +Soft tissue sarcoma 0.3372292343787852 0.520836046904779 0.6024809896356027 1.0 0.8317461927052915 27 Q13126,P21912,Q15392 3 +Mild microcephaly 0.4856469536521488 0.5203287492870965 0.6028344613518162 1.0 0.8317461927052915 7 Q05086 1 +Aplasia hypoplasia involving the nose 0.3479155652445752 0.5202810118452198 0.6028677283579129 1.0 0.8317461927052915 22 O75844,O75431,P55795 3 +Biliary cirrhosis 0.497805617389475 0.5193576419074303 0.6035113638171028 1.0 0.8323783038755861 6 Q14739 1 +Edema of the dorsum of feet 0.4073938506588523 0.5176932586283938 0.6046723025072369 1.0 0.8332113274953882 2 Q9Y5S9 1 +Edema of the dorsum of hands 0.4073938506588523 0.5176932586283938 0.6046723025072369 1.0 0.8332113274953882 2 Q9Y5S9 1 +Aplasia cutis congenita of scalp 0.4972891992037937 0.5172727734795041 0.6049657572611808 1.0 0.8332500199414842 6 Q13363 1 +Abnormal synaptic transmission at the neuromuscular junction 0.338896203357943 0.5171209847214914 0.6050717056571517 1.0 0.8332500199414842 26 P35637,Q9H845,Q15165,P43243,Q92804,Q9Y5P6 6 +Metaphyseal widening 0.3835481275273499 0.5146724098985286 0.6067819562636245 1.0 0.8347070822766187 14 Q96L58,Q14739 2 +Aplasia hypoplasia of the sacrum 0.4605480219316465 0.5145411332166525 0.606873709774645 1.0 0.8347070822766187 3 Q8TAA9 1 +Multifocal epileptiform discharges 0.3500080251855906 0.5141077201271639 0.6071766801786462 1.0 0.8347086115222424 21 O14936,Q96N66,Q9UBX3 3 +Abnormality of the choanae 0.3315864933386888 0.5140074312042268 0.6072467951470859 1.0 0.8347086115222424 29 Q9UBM7,P21964,O75844,P48651,P16435 5 +Hip dislocation 0.303079050041136 0.5135430297578869 0.60757151912127 1.0 0.8348992583638274 53 Q8TD16,Q96A33,O95202,Q8NBU5,Q9UBM7,O75844,Q96L58,P25054,Q13363,Q9Y487,Q9Y5P6 11 +Abnormal anterior eye segment morphology 0.2589941722878485 0.5102054305658795 0.609907548017393 1.0 0.8365615126627596 252 Q8IWS0,Q8NCH0,P21912,P23786,P25054,O75845,P08236,Q9NR77,P01889,Q96EK5,Q02978,Q9UHX1,P51648,P11166,Q9NX14,Q06136,P21964,Q13363,O76024,Q10713,P36507,P09651,O14936,P08670,Q15125,O95202,P22626,Q99797,Q96L58,Q7LGA3,Q9NWM8,P04062,O60313,Q05086,Q13126,Q15800,Q9NVI7,O14979,Q14739,O75844,Q9UBM7,P48449,Q9H6K4,O75381,Q9Y5P6,Q8WWV3 46 +Decreased circulating androgen concentration 0.4953579155051662 0.509493931159601 0.6104060511464229 1.0 0.8367447640638809 6 P16435 1 +Spinal cord compression 0.5133828715021742 0.5080339682821192 0.6114295215535344 1.0 0.8378918145747365 4 Q96L58 1 +Toe syndactyly 0.3018950044445307 0.5071298277977901 0.6120637274641116 1.0 0.838504886709076 48 Q15125,P37268,Q9UBM7,P25054,O75845,O43924,Q9UHX1 7 +Bird like facies 0.4942582357925014 0.5050775391519815 0.6135043763547847 1.0 0.8400668001906001 6 O75844,P02545,P19447 3 +Nonimmune hydrops fetalis 0.3373036419088487 0.5044472052936679 0.6139471531176175 1.0 0.8400668001906001 26 P04062,O96000,Q9H0R6,Q14739 4 +Abnormal tracheal morphology 0.3303866468445379 0.5039711988467056 0.6142816162240341 1.0 0.8402608636432384 29 Q15125,Q96L58,Q14739 3 +Spastic paraplegia 0.3042437823419208 0.5034149032142209 0.614672595735765 1.0 0.8404288591599934 44 Q9Y619,P11166,O75298,Q96CU9,Q9H0B6,P04062,O75306,Q9P0J0,Q8N0X7,Q7KZN9,Q5T440,O60313 12 +Cardiac conduction abnormality 0.3390656185452029 0.5032636012120967 0.6147789537928383 1.0 0.8404288591599934 25 P21912,O75306,O43772,P23786,P50402 5 +Intestinal hypoplasia 0.5117584214044754 0.5019882329543036 0.6156757982431276 1.0 0.8408995641959289 4 O75844,Q99567 2 +Papule 0.3656812868442026 0.5017084380901109 0.6158726280588436 1.0 0.8408995641959289 16 P01889,P21912,O75844,P16615 4 +Regional abnormality of skin 0.2713850473469187 0.5013424522630847 0.6161301331176543 1.0 0.8408995641959289 113 Q8NCH0,P21912,P98175,P25054,P40855,P61978,Q9Y487,P16615,Q99567,Q9UHX1,Q06136,P09493,P02545,Q13363,P57740,P55795,P36507,O75431,O95453,P53634,O95202,P41227,Q7LGA3,Q92917,Q96J02,P50542,Q9UBM7,Q14739,P62266,P42167,P78347,O75381 32 +Abnormal peripheral action potential amplitude 0.4808431937945424 0.5001330729309681 0.6169813798395893 1.0 0.8413893748769605 7 O15269,O60231 2 +Neoplasm 0.2661641241859955 0.4988816991118811 0.6178627274099078 1.0 0.8418238981832623 191 P36551,P21912,P25054,Q8TAA9,O43924,Q01844,Q02978,P16615,Q15392,Q06136,P16435,Q13363,P42892,Q10713,P53634,Q96L58,Q7LGA3,Q92804,P04062,P16930,Q13126,Q9BUK6,Q9UBM7,Q9NZJ7,P06737,P07602,O43681,P51809 28 +Eeg with focal epileptiform discharges 0.332183179995429 0.4984220115081426 0.6181866255036415 1.0 0.8420095827800738 28 Q96N66,Q9UBX3,O75503,O14936,Q05086 5 +Feeding difficulties 0.2604910513522804 0.495899195818204 0.619965533569349 1.0 0.8439003391158302 271 P37268,P21912,O75306,P23786,O96000,O43924,Q9Y6M9,P61978,Q9Y487,Q96A33,P35637,Q15392,P21964,Q99707,Q13363,O76024,P55795,Q10713,O14936,Q96EY8,Q9UM00,Q8TD16,Q86Y39,Q96N66,Q99720,Q7LGA3,Q96J02,P40939,P04062,O60313,Q05086,O43676,Q9UBM7,Q9NZJ7,Q01105,P46977,P07602,O43681,Q16836,O75381,Q15233 41 +Congenital ichthyosiform erythroderma 0.4919036672870577 0.4956535200570739 0.6201388855623904 1.0 0.8439003391158302 6 Q15125 1 +Decreased circulating igg level 0.4263465808021847 0.4916160990058922 0.622990760370862 1.0 0.8470744110104307 11 Q13724,P17812,P50851,P13051,P18074,P00813 6 +Muscle fiber inclusion bodies 0.4533763222143797 0.4915833367777392 0.6230139255389999 1.0 0.8470744110104307 9 Q9Y5P6,O43676,P07196 3 +Abnormality of the lymphatic system 0.2714512251048143 0.4912829803371148 0.6232263157656956 1.0 0.8470744110104307 127 P36551,O15118,O75845,P08236,Q01844,P01889,Q13546,P11166,Q96A33,Q14108,Q15392,P28288,P21964,Q13363,P54802,Q10713,P36507,O14936,P00813,O95202,Q16625,P28070,Q6NUQ1,Q96J02,P04062,P16930,P31751,Q9BT22,Q14739,Q9NZJ7,P07602 31 +Mesomelia 0.490664091382382 0.4907100608289002 0.6236315296665293 1.0 0.8473685453052933 6 Q14739 1 +Macular degeneration 0.3878019664454216 0.4878416789612733 0.6256619869079236 1.0 0.8490397193478986 13 P04062,P51648 2 +Respiratory insufficiency 0.2673689262820315 0.487699210799232 0.6257629108509413 1.0 0.8490397193478986 156 P36551,O75306,P23786,O96000,Q9Y6M9,Q9NR77,P61960,P35637,Q15067,Q16637,Q70HW3,Q9NX14,Q15165,O76024,P09651,Q8TD16,Q86Y39,Q9HCC0,Q8NBU5,Q96L58,P50570,Q92804,P40939,O43676,Q9BT22,Q14739,Q9NZJ7,O43772,P43243,P07602,O75381,Q9Y5P6,P50402 33 +Epiphyseal dysplasia 0.5114246623587797 0.4876822586676817 0.6257749201479683 1.0 0.8490397193478986 5 Q9HC07 1 +Heterotropia 0.3052053305948681 0.4876364803970059 0.6258073510701534 1.0 0.8490397193478986 42 Q9NVI7,P50542,P25054,O43819,P19447,Q10471,O43924,P55795,P27635,P40939,Q05086,P04062,P53007,Q9UHX1,Q15233 15 +Abnormality of hair texture 0.3025369014489086 0.4859722584011942 0.6269868350725241 1.0 0.8502199248076475 44 Q15125,Q96A33,O75844,P54802,P55795,Q9Y487,Q9UM00 7 +Scapular winging 0.3459138485836188 0.4844923757510917 0.6280364739417941 1.0 0.8506438053659695 21 Q8TD16,Q9Y487,P07196,P02545,O60313,Q9Y5P6,P50402 7 +Localized skin lesion 0.2650556242593011 0.4842972940389965 0.6281748960781668 1.0 0.8506438053659695 183 P36551,Q8NCH0,P21912,P25054,Q8TAA9,P01889,P61978,P16615,P35637,Q15392,Q06136,P21964,Q13363,O75431,P38435,Q9UM00,Q15125,P53634,O95202,Q96L58,Q7LGA3,Q9NWM8,P04062,Q13126,Q14739,O75844,Q9NZJ7,P07602,Q15233 29 +Peptic ulcer 0.4517365347055656 0.4840978217065941 0.6283164471453184 1.0 0.8506438053659695 9 O76024,P04062 2 +Abnormality of skeletal maturation 0.2874885781410068 0.4815173593923417 0.6301488450220354 1.0 0.8526101948926423 69 Q15800,O95202,Q14108,Q9BUK6,P13073,P48651,P51809,P16435,Q13363,P48449,P04062 11 +Anonychia 0.3859584393661298 0.4774353334072997 0.6330521587789453 1.0 0.8562803160337271 13 O14936,P16615,Q14739 3 +Tibial torsion 0.3982430453879882 0.4765466734500033 0.633684964258334 1.0 0.8566199155395792 2 Q9Y5S9 1 +Inappropriate crying 0.4748030752319723 0.4750101543498395 0.6347797356373173 1.0 0.8573440684193889 7 Q9NZJ7 1 +Abnormal lumbar spine morphology 0.4364264349557737 0.4742277083670829 0.6353375364605234 1.0 0.8577480481745664 10 P04062,P08236 2 +Mixed hearing impairment 0.4864148208894267 0.473859953800988 0.6355997779098761 1.0 0.8577480481745664 6 Q9NWM8 1 +Short clavicles 0.4617490427349121 0.4718563109119951 0.6370293541704066 1.0 0.8586445132602041 8 O75431 1 +Sleep disturbance 0.2696992552449318 0.4699283774478929 0.6384061892052881 1.0 0.8596360567516751 116 P36551,P50897,P07196,P61978,P11166,Q96A33,O76024,P54802,O14936,O75503,Q96N66,Q8NBU5,Q7LGA3,P04062,Q05086,Q9NVI7,Q9UBM7,Q8N0X7,Q01105,P06737,Q15233 21 +Flat occiput 0.4482982187970716 0.468483240197193 0.6394390535235324 1.0 0.8599947474418979 9 P50542,O75381,Q05086,P62266 4 +Spastic gait 0.3460825797704513 0.4676485732289342 0.6400359230751764 1.0 0.8603292762787594 20 Q8N0X7,O75298,Q9NVI7,P25054 4 +Everted upper lip vermilion 0.448216596172614 0.4647327484899017 0.6421228533392178 1.0 0.8623641062931772 3 P04062 1 +Macroglossia 0.3277643597219832 0.4623213034892245 0.643850924686342 1.0 0.8638573934103743 28 Q96A33,P21912,Q7LGA3,Q10713,P61978,Q05086 6 +Glaucoma 0.2772825614691729 0.4582308837190869 0.6467865739846239 1.0 0.8667596727509681 80 Q15125,Q06136,Q8NCH0,P21964,Q96L58,O75381,Q86XL3 7 +Childhood onset 0.3222027606300123 0.4572244921180228 0.6475096959028823 1.0 0.8674697060334734 30 P50402,Q8TB36,Q5JRX3,Q8N0X7,Q9NR77,O75431,Q8WWV3 7 +Ovarian cyst 0.3737190638057839 0.4567280378431252 0.6478665354990047 1.0 0.8676887530049338 14 P21912,P31751,P16435,P78347 4 +Abnormal finger phalanx morphology 0.2691644568020498 0.4541528153539101 0.6497188415395008 1.0 0.8693912226682408 129 Q8IWS0,P98175,O75845,O43924,Q9UHX1,Q15067,P21964,P16435,Q13363,O76024,Q10713,O75431,P38435,Q9UM00,Q15125,P53634,O95202,Q96L58,Q7LGA3,P48651,Q9UBM7,Q14739,O75844,Q15233 24 +Abnormal cardiac septum morphology 0.2622632159038176 0.4535823529018223 0.6501294573854282 1.0 0.8696813725024743 171 Q8NCH0,Q9H9C1,O75306,P98175,P46976,Q7KZN9,P61978,Q9Y487,Q9UHX1,Q16637,Q9NX14,P21964,P55263,P16435,Q13363,P42892,P55795,P36507,O14936,O75431,Q9UM00,O95202,Q96L58,Q9P0J0,P50542,Q9UBM7,Q14739,O75844,O75381,Q9H267,Q15233 31 +Abnormality of lower limb epiphysis morphology 0.3997491569860364 0.4509532690090105 0.6520232297267963 1.0 0.8711760211413699 12 Q96L58,Q7LGA3,Q6NUQ1 3 +Abnormal aortic valve physiology 0.3128497285343763 0.4492124102369546 0.653278435854187 1.0 0.8714290987357145 33 Q15125,P78347,O75844,P01889,P04062,Q9UHX1 6 +Waddling gait 0.3409846629457304 0.4491406916735711 0.6533301679541488 1.0 0.8714290987357145 21 Q8TD16,P22626,P07196,P02545,Q9BTV4,P09651,P53007,Q9Y5P6,P50402 9 +Skeletal dysplasia 0.3128342129711751 0.449074859759378 0.6533776553577717 1.0 0.8714290987357145 33 Q9HC07,O75381,P51648,Q14739 4 +Retinal arteriolar tortuosity 0.4683753598228932 0.448627408134182 0.6537004587361581 1.0 0.8714818388892566 7 P21964 1 +Aplasia of the uterus 0.4558958832940774 0.4467168624122992 0.6550795051762761 1.0 0.8722326876067833 8 Q13363,O96028,O95202,Q9Y5S9 4 +Proximal muscle weakness in lower limbs 0.3569979279816989 0.4465184732962842 0.6552227715011709 1.0 0.8722326876067833 16 P36551,Q16637,P50570,P07196,P50402 5 +Aplasia hypoplasia of the clavicles 0.4172836946327412 0.4463553195437681 0.6553406021858452 1.0 0.8722326876067833 11 Q9Y619,O75844,P48651,P02545,O75431 5 +Interictal eeg abnormality 0.2898321584380909 0.4457252659917429 0.6557957114275113 1.0 0.8723279381803212 64 P11166,Q9NQZ5,Q14108,Q96N66,P13073,Q9BSJ2,Q9UBX3,P00367,Q05086,O14936,O75503 11 +Abnormal ovarian morphology 0.3356050144582475 0.4453701500991345 0.65605228012554 1.0 0.8723279381803212 23 O75312,P78347,P21912,P16435,P02545,P51809,P31751 7 +Ridged nail 0.4999342174266896 0.4452835782951733 0.6561148337895382 1.0 0.8723279381803212 5 P19447,P16615 2 +Severe intrauterine growth retardation 0.4430611497619918 0.4443822152398601 0.6567662694206964 1.0 0.872835954148678 3 Q92979,Q15813 2 +Abnormal cornea morphology 0.2684657117226897 0.4423279487665252 0.6582519091574679 1.0 0.874292562384941 127 Q8NCH0,O75845,P08236,P01889,Q96EK5,P51648,Q9NX14,Q06136,P21964,Q13363,Q15125,O95202,Q16625,Q96L58,Q7LGA3,Q9NWM8,P50542,P04062,Q9NVI7,Q9UBM7,Q14739,O75844,O75381,Q9Y5P6 24 +Aplasia hypoplasia of the cerebellar vermis 0.2959143332737426 0.4386232693114386 0.6609345334888705 1.0 0.8760064309242445 55 Q8NFH4,Q15125,Q9UBM7,P23786,O43924,Q10713,Q9Y487,Q9Y5P6,Q9UM00 9 +Spinal muscular atrophy 0.4287336110629943 0.437891834162358 0.6614646953457908 1.0 0.8760064309242445 10 Q8TD16,Q99720 2 +Widely spaced teeth 0.328797933347755 0.4373865108486451 0.6618310650944508 1.0 0.8760064309242445 26 Q96A33,P08236,Q05086 3 +Chronic constipation 0.3366147569597357 0.4371980926987356 0.6619676928427816 1.0 0.8760064309242445 22 Q7LGA3,P55795 2 +Overlapping fingers 0.4768902815236164 0.4366595931638562 0.6623582373210266 1.0 0.8760064309242445 6 Q15125 1 +Urinary bladder sphincter dysfunction 0.4534728227727309 0.4364066754722347 0.6625416964959492 1.0 0.8760064309242445 8 P09651,Q9NR77,P22626 3 +Poor eye contact 0.3085349312977833 0.4362363010948284 0.6626652925552161 1.0 0.8760064309242445 34 Q86Y39,Q9NX14,O75306,Q9P0J0,O96000,Q9Y6M9,Q9UHX1,O43676 8 +Abnormal epidermal morphology 0.355309960200163 0.4359058939776297 0.6629050086357307 1.0 0.8760652764302589 16 Q06136,O75844,P16615 3 +Abnormal blood sodium concentration 0.4407116820400174 0.4344388233488664 0.6639698104871246 1.0 0.8769560063173087 9 P36551 1 +Neoplasm of the male external genitalia 0.440518705922027 0.4335805095968036 0.6645930906629902 1.0 0.877262879675147 9 P51809,Q01844 2 +Abnormal systemic blood pressure 0.2756042720760274 0.4317501300667364 0.665923028541465 1.0 0.878759938869184 78 P36551,P01889,O75844,P21964,Q9NZJ7,P21912,O43772,P16435,Q8TAA9,P42892,Q10713,Q96J02,P07602,O43681,P04062,Q02978 16 +Unsteady gait 0.2983735462586686 0.4312271241778231 0.6663032333754466 1.0 0.8787829858969708 43 P49366,P11166,Q5JRX3,P07196,Q9H6K4,Q9NR77,Q10713,P43243,Q13153,O75503 10 +Abnormality of the lens 0.2614491541203916 0.4310270579015381 0.6664486964185068 1.0 0.8787829858969708 174 Q8IWS0,P21912,P23786,P25054,O75845,P01889,P11166,Q9NX14,Q06136,P21964,O76024,Q10713,P36507,P09651,O14936,P08670,Q15125,P22626,Q99797,Q16625,Q96L58,Q7LGA3,P50542,O60313,Q13126,Q15800,Q9NVI7,O14979,Q9UBM7,P48449,Q9H6K4,O75381,Q9Y5P6,Q8WWV3 34 +Abnormal circulating carboxylic acid concentration 0.2747575755076856 0.4291521347099554 0.6678125138350823 1.0 0.8788415968236009 82 P36551,P11166,P37268,Q14739,Q9H9C1,P55263,P23786,P41440,O96000,P05067,O14936,P16930,Q96EY8,Q9H267 14 +Iron deficiency anemia 0.4954320858673065 0.4289726726215582 0.6679431120243544 1.0 0.8788415968236009 5 P28288,P25054 2 +Retrognathia 0.2830414894878689 0.4262474085299976 0.6699275754416074 1.0 0.8803240371396951 69 Q15125,Q15392,P37268,O75844,Q8NCH0,Q7LGA3,Q13363 7 +Abnormal upper motor neuron morphology 0.4261785491608794 0.425962486129919 0.670135181595584 1.0 0.8803240371396951 10 P35637,Q99720 2 +Skeletal muscle atrophy 0.2662582312477706 0.4258094367004183 0.6702467100949951 1.0 0.8803240371396951 144 Q13057,Q8IWS0,Q8TB36,P21912,P07196,P46976,Q9NR77,P35637,Q16637,Q15165,P55263,P09651,Q8TD16,O75298,Q9HCC0,Q6P4A7,Q99720,P22626,P50570,Q9NWM8,Q15120,Q92804,O60313,Q13126,Q9NVI7,Q9BUK6,O14979,Q9H0B6,Q8N0X7,O15269,P43243,Q9Y5P6,P50402,P31483 34 +Abnormality of globe location 0.2612285408947574 0.4253364818665465 0.6705914024736428 1.0 0.8805190796669715 220 Q9Y2R0,Q32P28,Q8IWS0,Q8NCH0,P98175,P25054,O43924,Q96EK5,P61978,Q9Y487,Q9UHX1,Q96A33,Q15067,P21964,P55263,P16435,Q13363,P55795,P36507,O14936,O75431,Q13153,Q9UM00,P49366,Q15125,O95202,Q96L58,Q7LGA3,P48651,Q92917,Q96J02,P04062,Q05086,Q9BT22,Q9NVI7,Q9BUK6,Q9UBM7,Q14739,O75844,O75312,Q8N0X7,Q01105,Q15233 43 +Abnormal ldl cholesterol concentration 0.3759268577568616 0.4215207009656652 0.6733748982171821 1.0 0.882882425708067 13 Q8N511,P37268 2 +Cervical ribs 0.4369925799588717 0.4208118269426131 0.6738924946996698 1.0 0.8832658702787489 3 Q9UHX1 1 +Myopathic facies 0.4930368819133596 0.4203680189662799 0.6742166272966794 1.0 0.8832658702787489 5 Q9BUK6 1 +Hypergalactosemia 0.3850658857979445 0.4193285336124988 0.6749760460483516 1.0 0.8832658702787489 2 Q9UJS0 1 +Increased nuchal translucency 0.3672486004163769 0.4192341801387311 0.675044994442092 1.0 0.8832658702787489 14 P61978,Q9UBM7 2 +Abnormality of the zygomatic bone 0.2882563823747939 0.4164579121488782 0.6770749589299849 1.0 0.88514780532414 63 Q9HC07,Q15125,Q14739,P21964,Q96L58,P16435,Q9Y487,Q15233 8 +Episodic pain 0.42394163062406 0.4155784116179726 0.677718526633595 1.0 0.8854732889466009 10 P21912,Q02978,P23786 3 +Generalized onset seizure 0.2734223814798816 0.4138588901673325 0.6789774524005181 1.0 0.8864267028413267 83 Q14108,Q96N66,P61978,Q9NZJ7,P21912,P00367,Q01105,P07602,O14936,P04062,O75503,Q05086 12 +Aplasia hypoplasia involving bones of the feet 0.2933273184500247 0.4135721816728801 0.679187449637416 1.0 0.8864267028413267 51 Q96A33,Q8IWS0,O95202,P13073,Q9UBM7,Q7LGA3,P25054,Q8N0X7,Q13363,Q9UHX1,Q13555 11 +Cachexia 0.3437136988614805 0.4135027790105388 0.6792382867805977 1.0 0.8864267028413267 17 P35637,Q99720,Q9NZJ7,P07602,P04062 5 +Disinhibition 0.2996519131628914 0.4131606220871416 0.6794889365360717 1.0 0.8864960311552005 40 P35637,Q96N66,Q8TAA9,P05067,P04062 5 +Prolonged neonatal jaundice 0.366025666766216 0.4122115914143653 0.6801843418242859 1.0 0.8869491117007678 14 O14936,O15118 2 +Gynecomastia 0.3433416060400174 0.4110873974152393 0.6810084506268517 1.0 0.8869491117007678 17 P21912,P51809,P31751 3 +Arthralgia 0.3190999850617882 0.4106911679231026 0.6812990039772271 1.0 0.8869491117007678 29 Q15800,P78347,P25054,P02545,P19447,P28070,P01889 7 +Motor seizure 0.2733842961559238 0.4105299580796657 0.6814172319840124 1.0 0.8869491117007678 82 Q96N66,P13073,Q9NZJ7,P21912,Q9UBX3,Q01105,Q05086,P07602,O14936,P04062,O75503,Q8WWV3 12 +Abnormality of refraction 0.2656950292002257 0.4097644831786862 0.6819787223871538 1.0 0.8869677796780804 114 Q8NCH0,P21912,P98175,P61978,Q9Y487,Q9UHX1,P51648,Q96A33,Q15067,Q9NX14,O60488,O14936,Q96L58,Q7LGA3,Q9NWM8,P40939,Q05086,Q13555,Q9NVI7,Q9Y5P6,Q15233 21 +Trichorrhexis nodosa 0.4339069937751741 0.4089938274578872 0.6825441909590659 1.0 0.8869677796780804 3 P18074,Q6PGP7 2 +Abnormality of the pubic bone 0.469646500454943 0.4089304489756544 0.6825907028518572 1.0 0.8869677796780804 6 Q13363,O95202 2 +Abnormality of lipoprotein cholesterol concentration 0.3654466663430731 0.4088941261008198 0.6826173598502874 1.0 0.8869677796780804 14 Q8N511,P37268 2 +Cherry red spot of the macula 0.4343493451334121 0.4063518094148514 0.6844841228734655 1.0 0.8883645874656197 9 Q9NZJ7 1 +Radial bowing 0.4843938849494864 0.4034419093498329 0.6866231612209228 1.0 0.8898540997861686 4 Q32P28 1 +Arterial stenosis 0.4083216496391022 0.4024935871007355 0.6873208069919747 1.0 0.8903324982630804 11 P01889,P21912,P78347 3 +Mandibular aplasia 0.4836698924746991 0.4009266685429041 0.6884741146483364 1.0 0.8907464601470879 4 Q9Y619,Q9NX14 2 +Abnormality of the anus 0.2998257036102382 0.3996232743447248 0.6894340112999722 1.0 0.8914754034180067 38 P21964,P48651,P16435,Q8TAA9,P16615,Q13546 6 +Ventriculomegaly 0.264317437078946 0.3974185876664193 0.6910588107837414 1.0 0.8927668229123292 146 Q15125,Q8TD16,Q15392,Q9UBM7,Q8NCH0,Q9NZJ7,O75306,P23786,Q13363,P35606,Q01105,Q10713,P07602,O14936,P04062,Q9Y487,Q86XL3,Q9UM00 18 +Abnormal hand bone ossification 0.4663150007925573 0.3963513010207995 0.6918458866470891 1.0 0.8928409519971722 6 Q15125 1 +Generalized amyotrophy 0.3309464513926092 0.3962617388447947 0.6919119498765964 1.0 0.8928409519971722 22 P35637,P22626,P02545,P09651,Q9BQP7,Q9Y5P6,Q99567 7 +Hyperpituitarism 0.3488250653475394 0.3955222439106624 0.6924575088047877 1.0 0.8930314079068642 16 Q9BUK6,P16435 2 +Hand tremor 0.4067376196125513 0.3948417900070307 0.692959651482892 1.0 0.8933404346978742 11 Q15120,P07196 2 +Motor polyneuropathy 0.4066995122625737 0.3946580983982459 0.6930952303070406 1.0 0.8933404346978742 11 P36551,O43819,P53007,P07196 4 +Large face 0.2916231539599876 0.3918524649169802 0.6951672272838336 1.0 0.8952397463557662 52 P36507,Q9NVI7,Q9BUK6,P21964,Q7LGA3,O00571,P25054,Q9UPP1,Q10471,O43924,Q10713,P27635,P61978,P53007,Q13153,Q92643,Q15233 17 +Abnormal carotid artery morphology 0.4057874533808863 0.3902671498532594 0.6963390118278883 1.0 0.8962344379362095 11 O75844,P78347 2 +Weight loss 0.2882172440706561 0.3883007958588134 0.6977934483689694 1.0 0.897255773478068 60 P35637,Q99720,Q06136,O75844,P21912,Q9NZJ7,P42892,Q01844,P07602,P04062,Q02978 11 +Chronic atrophic gastritis 0.3766471449487526 0.3841636669662439 0.7008571455487571 1.0 0.8982891267206131 2 P50851 1 +Reduced tendon reflexes 0.2643712452761562 0.3835725576881508 0.7012952827802152 1.0 0.8982891267206131 139 Q13057,Q8TB36,P07196,P41440,Q8TAA9,P40855,Q9NR77,P61978,P35637,Q15067,Q16637,Q96BR5,P02545,O60701,P05023,P54802,Q10713,Q5T440,O95453,O00429,Q8TD16,Q99720,P50570,Q15120,P40939,Q9BQP7,P04062,O60313,P50542,Q9BT22,Q9BUK6,O14979,Q9H0B6,P35610,Q9NZJ7,O43819,P19447,Q9H6K4,O15269,O60231,P07602,O43681,P53007,O75381,Q9Y5P6,P50402 46 +Abnormal corneal epithelium morphology 0.3468764290283868 0.3835150330838586 0.7013379260083092 1.0 0.8982891267206131 16 P01889,O75844,P51648,Q14739 4 +Sparse hair 0.2826732833138011 0.3832475127745931 0.7015362522838107 1.0 0.8982891267206131 66 Q15125,Q8IWS0,P53634,O75844,Q96L58,P48651,P48449,Q96EK5,O75431,P51809,Q9Y487,Q9UM00 12 +Abnormal jaw morphology 0.2590655906224907 0.3819491697267964 0.7024990679660172 1.0 0.8982891267206131 221 Q13057,P37268,Q8NCH0,P98175,P25054,O75845,O43924,Q96EK5,Q86XL3,Q9UHX1,Q15392,P21964,Q13363,P55795,O14936,O75431,Q9UM00,Q15125,Q8TD16,O95202,Q96L58,Q7LGA3,P48651,P04062,Q05086,Q9BT22,Q9NVI7,Q9BUK6,Q9UBM7,Q14739,O75844,Q9BSJ2,O75381,Q9H267 34 +Narrow forehead 0.2971806004138627 0.3817542153353966 0.7026436820825124 1.0 0.8982891267206131 39 Q96A33,Q9UBM7,Q7LGA3,Q9BSJ2,O75845,Q14671,P57740,P36507,Q9UHX1,Q13555,Q9UM00 11 +Bilateral cleft lip 0.3759150805270795 0.3811607669880275 0.7030839590083089 1.0 0.8982891267206131 2 Q9NXE4 1 +Renal tubular atrophy 0.4779055661440693 0.3810860251980956 0.7031394167044371 1.0 0.8982891267206131 4 P57740 1 +Abnormal peripheral nervous system morphology 0.2646864479429426 0.3807583785098433 0.703382546062512 1.0 0.8983152907394905 130 Q13057,Q9Y619,Q8TB36,P21912,P25054,P07196,P41440,P40855,Q9NR77,Q8IV08,Q02978,Q9UHX1,P35637,Q15067,Q16637,O60488,Q96BR5,P02545,O76024,P09651,Q5T440,Q99720,P22626,P50570,P48651,Q15120,Q9NRG9,P50542,Q9BQP7,O60313,Q9NVI7,Q9H0B6,Q9NZJ7,O43819,P19447,O15269,P43243,O60231,P07602,O43681,O75381,Q9Y5P6 42 +Abnormality of the hallux 0.2953214394720614 0.3804364819231691 0.7036214381125188 1.0 0.8983152907394905 41 Q15125,O95202,Q96L58,Q7LGA3,Q13363,Q96J02,P04062,Q15233 8 +Lower limb amyotrophy 0.3385063767248367 0.3799052871482212 0.7040157225014994 1.0 0.8983152907394905 17 Q8TD16,Q9NVI7,Q9H0B6,Q15120,P07196,Q9NR77 6 +Primary gonadal insufficiency 0.4397156871187748 0.3790333945613565 0.7046630655486954 1.0 0.8983152907394905 8 O76024,P51809,P49770,Q9NR50 4 +Dyslexia 0.4394770007780434 0.3780564386203347 0.705388667828811 1.0 0.8986046952074095 8 Q9H6K4,P25054 2 +Severe short stature 0.3307743952846271 0.3771260324146452 0.7060799460075835 1.0 0.8992300787973992 21 Q15392,Q9NX14,Q96L58,P21912,P48651 5 +Elevated creatine kinase after exercise 0.4764290781103203 0.3760580763236016 0.7068737207523943 1.0 0.899805115915717 4 O43772 1 +Premature graying of hair 0.4388813805798164 0.3756214159343929 0.7071983671669013 1.0 0.899805115915717 8 Q13126,P02545 2 +Psychosis 0.3258335231141981 0.3735299675860825 0.7087540457399624 1.0 0.9008462637442513 23 P36551,Q5JRX3,O15118,Q8N0X7 4 +Female sexual dysfunction 0.4751444248886939 0.3717017243974684 0.7101149409727738 1.0 0.9015546973368626 4 P01889 1 +Autism 0.3064096145008083 0.3698648397329694 0.7114832003774463 1.0 0.9027810583245628 32 Q9UBM7,P21964,P21912,Q05086,Q15233 5 +Enlarged posterior fossa 0.2965284574284352 0.3689336842732813 0.712177155264061 1.0 0.9034061822569548 38 Q9Y487,P23786 2 +Retinal dysplasia 0.4371109382245883 0.3684079743712639 0.7125690522799584 1.0 0.9036478967596646 8 O43924,Q10713 2 +Thoracic scoliosis 0.3836212072982694 0.3678572314478984 0.712979691889041 1.0 0.9037523274138728 12 O75844,P50542,Q9UHX1,Q96J02 4 +Cessation of head growth 0.4477959454654172 0.3668959749918848 0.713696613902483 1.0 0.9037523274138728 7 P49770,Q05086,Q9NR50 3 +Paraplegia paraparesis 0.2792814102299612 0.3667818783900722 0.7137817259608266 1.0 0.9037523274138728 68 Q13057,Q9Y619,Q15041,Q96CU9,P21912,O75306,Q7KZN9,P18074,P11166,P35637,Q5T440,O00429,O75298,Q9NVV4,Q96L58,Q9P0J0,P04062,O60313,Q9H0B6,Q8N0X7,Q9H6K4,P19447 22 +Axial muscle weakness 0.4732333496003804 0.3652530650460232 0.7149225102633996 1.0 0.904077832082879 4 Q8TD16,Q9Y5P6 2 +Vertebral fusion 0.4125070856386832 0.3634287967129539 0.716284593559974 1.0 0.9055451425062432 10 Q13363,Q8TAA9,O95202 3 +Inappropriate antidiuretic hormone secretion 0.3711566617862302 0.3618649839418433 0.7174529279061361 1.0 0.9065103686309895 2 Q13724 1 +Abnormal emotion affect behavior 0.259207220905435 0.3609451469214804 0.7181404529859581 1.0 0.9068506688106374 192 P50897,P37268,P21912,O75306,P01889,P11166,P35637,Q15067,Q15165,P54802,P55795,Q10713,O14936,O75503,Q9UM00,Q15125,Q92804,P04062,Q05086,Q8N1F7,Q9UBM7,Q9NZJ7,O43772,Q8N0X7,Q01105,P06737,P07602,O43681,P51572,Q15233 30 +Movement abnormality of the tongue 0.4717948717948734 0.3604246042932992 0.7185296297439008 1.0 0.9068506688106374 4 Q9NVV4,P04350,P10253 3 +Cholestasis 0.2815217091454172 0.3583565956203848 0.7200764692810169 1.0 0.9084762076977952 65 P36551,P11166,P28288,Q9UBM7,P50542,Q16625,P53004,Q9H9C1,Q14739,O15118,P55263,O75845,Q6NUQ1,P40939,O14936,O75381,Q9H267 17 +Absent toe 0.3350718031568829 0.3579993552925435 0.7203437960206527 1.0 0.9084762076977952 17 Q13363,Q7LGA3,O95202,P25054 4 +Aplasia hypoplasia involving bones of the lower limbs 0.2763810830223278 0.3578910196690181 0.7204248714787105 1.0 0.9084762076977952 70 Q96A33,Q8IWS0,O95202,P13073,Q9UBM7,Q96L58,Q7LGA3,P25054,Q8N0X7,Q13363,P00813,Q9UHX1,Q13555,O75431 14 +Infection related seizure 0.3335003155649355 0.3566099517427915 0.7213838262959902 1.0 0.9091745611952832 18 P05067,O14936,Q96N66 3 +Abnormality of the voice 0.2616766995716352 0.3540789461687388 0.72327971984897 1.0 0.9105843678224468 102 P50402,O75844,P21964,Q7LGA3,P21912,Q8N0X7,O60313,Q9NR77,P43243,O75431,P04062,Q9Y487,Q02978,Q9Y5P6,Q15233 15 +Fasciculations 0.3017647940637601 0.3522224929284538 0.7246714095395066 1.0 0.9120373768966084 33 Q8TD16,P35637,Q16637,P22626,Q8NBU5,Q9NZJ7,P07196,P07602 8 +Impaired distal vibration sensation 0.4692307692307711 0.3518728863103985 0.7249335940328403 1.0 0.9121115699521692 4 Q06787,P20700,P54886 3 +Otitis media 0.2912726427474699 0.3508138961834028 0.7257279713347624 1.0 0.912855138831394 42 Q96A33,Q9UBM7,Q14739,P21964,Q13432,Q13363 6 +Mania 0.4213756635953988 0.3505266271152107 0.7259435106056702 1.0 0.9128704050429384 9 P16615 1 +Angiokeratoma 0.4175119408022824 0.3482238656006515 0.7276720659234646 1.0 0.9143045904325056 3 P04066 1 +Abnormality of vitamin b12 metabolism 0.4206522830415518 0.3474752928757926 0.7282342769783432 1.0 0.9143045904325056 9 P41440,Q96EY8 2 +Abnormal endocardium morphology 0.3795074193059266 0.3472325714427012 0.72841660286793 1.0 0.9143045904325056 12 P01889,P04062 2 +Erythroid hyperplasia 0.417063346759429 0.3466116235186889 0.7288831123670021 1.0 0.9143045904325056 3 O75533,Q86SX6 2 +Abnormality of dental color 0.4170633467594287 0.3466116235186885 0.7288831123670023 1.0 0.9143045904325056 3 P16278,Q6P4Q7 2 +Abnormality of the midface 0.2624792192607235 0.3444956851691935 0.7304735404224112 1.0 0.9154449535700572 129 Q9HC07,P25054,O75845,P61978,Q9Y487,Q9UHX1,Q96A33,Q9NX14,P21964,O60488,P16435,Q13363,P55795,O75431,Q9UM00,Q15125,Q8TD16,O95202,Q96L58,Q96J02,O75312,Q14739,Q9BSJ2,Q8N0X7,Q15233 25 +Abnormal circulating igg level 0.3789149956920742 0.3442833023979946 0.7306332403744946 1.0 0.9154449535700572 12 Q13724,P17812,P50851,P13051,P18074,P00813 6 +Abnormality of the pinna 0.2583092172316609 0.3440181099010406 0.730832666676861 1.0 0.9154449535700572 191 P36551,Q8IWS0,P37268,Q8NCH0,P98175,P23786,P25054,Q96EK5,P61978,Q9UHX1,P11166,Q96A33,Q15392,Q9NX14,Q06136,P21964,P16435,Q13363,O76024,P42892,P36507,O14936,Q13153,Q15125,Q8TD16,O95202,Q7LGA3,P48651,P38159,P50542,P04062,Q92643,Q13555,P62266,O75844,Q9BSJ2,P48449,Q01105 38 +Abnormal intestine morphology 0.2587722646395742 0.3419246454121334 0.7324076019059866 1.0 0.9158748149224184 158 P36551,Q8NCH0,P21912,P98175,P25054,Q8TAA9,Q01844,P01889,P61978,Q96EK5,Q13546,Q96A33,Q15392,Q9NX14,P21964,Q13363,O76024,P42892,P09601,Q10713,O95202,Q96J02,P16930,P08183,Q9BT22,O75312,Q9UBM7,Q14739,O75844,O75381 30 +Abnormal corpus callosum morphology 0.2547282306805788 0.3412860990264477 0.7328882117654132 1.0 0.9158748149224184 237 Q13057,P37268,P98175,P23786,P35606,O43924,Q96EK5,P61978,Q86XL3,Q9UHX1,Q96A33,Q15392,Q13363,Q10713,O14936,O75503,Q9UM00,Q15125,Q8TD16,O95202,Q96N66,Q7LGA3,P48651,Q9UBX3,P04062,O60313,Q05086,Q9NVI7,Q9UBM7,Q9NZJ7,Q9BSJ2,P48449,Q01105,P07602,P51572,Q9Y5P6,Q15233 37 +Abnormal tracheobronchial morphology 0.2860072164981222 0.3408323610640888 0.733229786943832 1.0 0.9158748149224184 48 Q15125,Q9UBM7,Q14739,Q96L58,P16435,Q13432,Q13546 7 +Hypochromic anemia 0.418912463738628 0.3401643940599707 0.7337327304427737 1.0 0.9162472159786222 9 O75027,P25054 2 +Abnormal protein glycosylation 0.3528223445762566 0.3378334098470374 0.7354887311651463 1.0 0.9179292061927632 14 Q9Y487 1 +Limitation of neck motion 0.4141340168436472 0.336153211499585 0.7367553337017336 1.0 0.9180405422054804 3 P02545,O94905 2 +Nephronophthisis 0.4141340168436471 0.3361532114995844 0.7367553337017341 1.0 0.9180405422054804 3 Q16658,Q9NQH7 2 +Femoral bowing 0.449895627429368 0.3360869940332611 0.7368052658253432 1.0 0.9180405422054804 6 Q32P28 1 +Abnormal pulmonary thoracic imaging finding 0.3314410386467928 0.3350774853637938 0.7375666361857784 1.0 0.918636259657067 17 P01889,Q96L58,P04062,P21964 4 +Dermatological manifestations of systemic disorders 0.2827811612907101 0.3349102975106151 0.7376927539670386 1.0 0.918636259657067 61 P36551,P11166,P28288,Q14739,Q16625,O75844,Q9H9C1,O15118,P98175,O43772,Q6NUQ1,O14936,O75381,Q9H267 14 +Intellectual disability moderate 0.284637695015211 0.3333174986564455 0.738894631878015 1.0 0.91885816233542 58 Q15125,O14936,Q96N66,P48651,P25054,P00367,P38159,Q01105,Q10713,P61978,Q9UHX1 11 +Hyporeflexia 0.2628136118117379 0.3322513161160003 0.7396994977968514 1.0 0.9190983748166232 97 Q13057,Q8TB36,P07196,P41440,Q9NR77,P35637,Q15067,Q16637,Q96BR5,P02545,P05023,P54802,Q10713,Q5T440,O95453,Q8TD16,Q99720,P50570,Q15120,P40939,Q9BQP7,P04062,P50542,Q9BUK6,O14979,Q9H0B6,P35610,Q9NZJ7,P19447,O15269,P07602,O43681 32 +Gait imbalance 0.3297163512027259 0.3322477796476929 0.7397021679673892 1.0 0.9190983748166232 18 Q05086,O15269,Q9NR77 3 +Mitral valve prolapse 0.3307312642795842 0.3306260307151954 0.740926981352392 1.0 0.919609761369231 17 Q9NX14,P78347,Q96L58,P02545,P53701,P55795 6 +Abnormality of primary teeth 0.3756958845295379 0.3283524627607958 0.7426451813968722 1.0 0.9205294605342492 12 O75844,P61978,Q9UM00 3 +Chest pain 0.3446838093235769 0.3282800781088603 0.7426999056583148 1.0 0.9205294605342492 15 P21912,Q02978,P25054 3 +Dysdiadochokinesis 0.3375587404860616 0.3270006671483148 0.7436673806183864 1.0 0.921109075085364 16 P41440,Q9BUK6,O75503 3 +Micromelia 0.3273455801080765 0.3268474564649478 0.7437832638389836 1.0 0.921109075085364 19 Q15392,Q9UBM7,Q14739 3 +Abnormality iris morphology 0.281192401516704 0.3253525524181604 0.7449142613310986 1.0 0.9222552289252332 62 O95202,Q9NX14,P50542,Q9UBM7,P21912,Q7LGA3,O75381,Q13363,Q9Y5P6,Q9NR77,Q10713,Q96EK5,Q05086,Q02978,Q9UHX1 15 +Abnormal scapula morphology 0.2863330121696759 0.323600426789618 0.7462405648086219 1.0 0.923262705963086 44 Q9Y619,Q8TD16,Q14739,P16435,P07196,P02545,O60313,Q9Y487,P46783,Q9Y5P6,P50402,Q9UM00 12 +Abnormal cardiac ventricle morphology 0.2563901594081676 0.3227081848589438 0.7469162529116353 1.0 0.9233857224535594 163 Q9H9C1,P21912,O75306,P23786,P46976,Q7KZN9,P61978,Q9UHX1,Q16637,Q9NX14,P21964,Q13363,P42892,P36507,O14936,O75431,O95202,Q96L58,Q9P0J0,P40939,P50542,Q9UBM7,Q14739,O75844,O43772,Q9Y5P6,O75381,Q9H267,Q15233 29 +Mutism 0.3496649852003292 0.3204730724918646 0.7486097398787224 1.0 0.924466170096816 14 P35637,Q9NX14,P22626 3 +Obstructive sleep apnea 0.4027501469375658 0.320274935755418 0.7487599216359015 1.0 0.924466170096816 10 Q96A33 1 +Sparse body hair 0.4246157748681443 0.318591181854145 0.7500365411344152 1.0 0.9255331307702104 8 P02545,P53634,P48449 3 +Melanocytic nevus 0.4124241805571086 0.3132582587213487 0.7540844599817729 1.0 0.9277852516906712 9 P21912,P19447 2 +Breast aplasia 0.4067315679953249 0.3102766213077458 0.7563506079547533 1.0 0.9300004187673788 3 Q9Y619 1 +Vascular neoplasm 0.2992445762431391 0.3093903534830505 0.7570246074843259 1.0 0.930574209364463 32 O95202,Q9UBM7,P21912,Q7LGA3,P16435,Q13363,P36507,Q02978,Q9UHX1 9 +Abnormal sharpey fiber morphology 0.455570068152054 0.3075519016637175 0.7584233241048366 1.0 0.9317831586593228 4 P01889 1 +Underdeveloped nasal alae 0.3265883870267329 0.3048450793794177 0.7604841461844005 1.0 0.93278295929915 17 O75431,P55795 2 +Large earlobe 0.4408672106280581 0.3042786077329642 0.7609156415221765 1.0 0.9329473596296358 6 Q8IWS0,Q15392 2 +Papilledema 0.353970252250957 0.3041233327397729 0.7610339312843353 1.0 0.9329473596296358 13 P04062,Q7LGA3 2 +Decreased absent ankle reflexes 0.3869816246266946 0.3022835212667595 0.7624359392444238 1.0 0.9341557453805552 11 Q9H6K4,O60313,Q15120 3 +T lymphocytopenia 0.4402040296099574 0.3019818876498948 0.7626658703332048 1.0 0.9341824306919824 6 Q13546,Q13432 2 +Abnormal circulating hormone concentration 0.2657797830747372 0.3005667633714111 0.7637448791078429 1.0 0.9347096775349448 75 O75844,P21912,Q9H0R6,P16435,P31751,P00367,P40939,O75431,P51809,Q16836,Q02978,Q9UM00 12 +Male reproductive system neoplasm 0.345704653326078 0.2989531352913189 0.7649758037698025 1.0 0.9354799474983306 14 P51809,Q01844,P25054 3 +Thickened calvaria 0.429451808981223 0.2980991009397793 0.7656275277410733 1.0 0.9356318398049724 7 P48651,Q15233 2 +Abnormal anatomic location of the heart 0.4190745855334145 0.2971500233222187 0.7663519750323196 1.0 0.9359266900201356 8 O75844,Q10713 2 +Exodeviation 0.3324152942021811 0.2964997553231395 0.7668484537947546 1.0 0.9359266900201356 16 O43819,Q10471,P55795,P40939,Q05086,Q9UHX1,Q15233 7 +Limb dystonia 0.3691116978398822 0.2962889292082135 0.7670094398159666 1.0 0.9359266900201356 12 Q99720 1 +Vitritis 0.4013823270702515 0.2920879120588515 0.7702194086774201 1.0 0.9378187230979628 3 Q9NX14 1 +Cranial nerve compression 0.4067638675384705 0.2902678196081423 0.7716113557562998 1.0 0.938816916767199 9 P21912,Q02978,P22626 3 +Megaloblastic anemia 0.4167559674480565 0.2883041913158532 0.7731138991006095 1.0 0.939289436698304 8 Q99707,P41440 2 +Hepatic cysts 0.3513909224011636 0.2861476791026444 0.7747650148995895 1.0 0.9397690234782048 2 Q9UGP8 1 +Abnormal circulating citrulline concentration 0.3993467548933132 0.2852827202656282 0.7754275502725592 1.0 0.9398626301139356 3 Q9Y619 1 +Abnormality of the helix 0.3034003678405625 0.2852267383458819 0.7754704365668235 1.0 0.9398626301139356 29 P36551,P62266,P21964,O75844,Q7LGA3,P23786,P02545,P36507,P50542 9 +Abnormality of complement system 0.3982424765746516 0.2816182677298618 0.7782362313041671 1.0 0.9408972859661976 3 P02545 1 +Sparse or absent eyelashes 0.3128775209205957 0.281200394344394 0.7785567022167654 1.0 0.9408972859661976 23 O75844,Q15125 2 +Neoplasm of the liver 0.2908626694874122 0.2810790900474019 0.7786497386441988 1.0 0.9408972859661976 34 P36551,P06737,P16930,P25054 4 +Abnormality of facial soft tissue 0.2592773582311534 0.2810679394786794 0.7786582909248492 1.0 0.9408972859661976 97 P21912,P07196,P40855,Q9UHX1,O60488,P16435,P02545,P57740,O00429,P50570,P48651,P28070,P50542,Q9BQP7,P04062,O60313,Q13555,Q8N1F7,Q8NFH4,Q9BUK6,Q9UBM7,P78347,O75844,P35270,O43819,P53007,O75381,Q9Y5P6,Q14C86 29 +X linked dominant inheritance 0.3128478285523411 0.2809932157774228 0.7787156033177927 1.0 0.9408972859661976 23 Q15125,Q9NX14,O60488,P41227,Q15120,O00571,P55795,O14936 8 +Morphological abnormality of the pyramidal tract 0.318462494583806 0.2801458544658599 0.7793656057920704 1.0 0.9408972859661976 20 P11166,P35637,O75298,P78347 4 +Sparse and thin eyebrow 0.3657177393192365 0.2800485346579751 0.7794402687410613 1.0 0.9408972859661976 12 Q15125,P48449,Q9UM00 3 +Gingival bleeding 0.3931276911963367 0.2790667775840434 0.7801935783176872 1.0 0.9408972859661976 10 Q14108 1 +Congenital onset 0.2599767054052772 0.2788926907855441 0.7803271779911465 1.0 0.9408972859661976 95 Q13057,O43924,Q96EK5,Q9UHX1,Q99567,Q9NX14,Q5T440,P08670,Q15125,Q8TD16,Q96N66,Q8NBU5,P50570,P41227,Q7LGA3,O75352,Q9NQT5,P50542,Q8NFH4,Q9NZJ7,Q9BW92,O43819,P46977,P07602,Q9Y5P6 25 +Abnormal conjunctiva morphology 0.3093164009773839 0.2782816462881206 0.7807961640353442 1.0 0.9408972859661976 25 P21912,P28070,Q14739 3 +Abnormal male reproductive system physiology 0.309210492783279 0.2775146078733037 0.7813849906835173 1.0 0.9408972859661976 25 O75298,Q13423,P51809,P16435,O76024,P04062 6 +Synostosis of carpals tarsals 0.4138902963767538 0.2774769726727068 0.7814138850455012 1.0 0.9408972859661976 8 Q96L58,P16435 2 +Carpal synostosis 0.4138902963767538 0.2774769726727068 0.7814138850455012 1.0 0.9408972859661976 8 Q96L58,P16435 2 +Wide mouth 0.2797363799674878 0.2756293569922313 0.7828327591542994 1.0 0.941917807797452 50 P11166,Q9UBM7,Q7LGA3,Q01105,P55795,Q05086,Q15233,Q9UM00 8 +Abnormal electroretinogram 0.2973821432617117 0.2731820382552621 0.7847132864338098 1.0 0.943674498798215 31 O14773,P50897,Q15067,O43924,P40939 5 +Abnormal urine cytology 0.2896880748461395 0.271069445396973 0.7863376211091029 1.0 0.9438891702959774 34 Q14108,P21912,P09601,P01889,P04062,Q02978,Q8N1F7 7 +Pain in head and neck region 0.3943610399121201 0.2688926218054729 0.7880123148899851 1.0 0.9446156168371178 3 O75533,P08397 2 +Hypocalcemia 0.3906958779087707 0.2688805769281938 0.7880215840994138 1.0 0.9446156168371178 10 P21964 1 +Esodeviation 0.2918011226374332 0.2676541175612074 0.7889655703852283 1.0 0.9454845880308198 33 Q9NVI7,P25054,O43924,P04062,Q13153,Q9UHX1 6 +Abnormal cardiac ventricular function 0.3338133185374491 0.2671177393514606 0.789378509659421 1.0 0.9454845880308198 15 O75844,Q15233 2 +Lymphedema 0.3788103377978359 0.2657392243519525 0.7904400524770789 1.0 0.9460570716054162 11 Q14739 1 +Progressive spastic paraplegia 0.3075342389360274 0.2654134038848094 0.7906910115247965 1.0 0.9460570716054162 25 O75298,Q96CU9,Q9H0B6,Q9P0J0,O75306,Q7KZN9 6 +Opisthotonus 0.3105657936925006 0.2651365569926101 0.7909042663588068 1.0 0.9460570716054162 23 P07602,Q9NZJ7,P35637,Q99720 4 +Abnormal lymphocyte morphology 0.3007867867125276 0.2649410679657311 0.7910548607556578 1.0 0.9460570716054162 29 O95470,Q13432,P17812,P28070,Q13546 5 +Abnormal uvea morphology 0.262708331770495 0.2645812687249971 0.791332051427525 1.0 0.9460570716054162 80 Q9Y619,P21912,P40855,Q9NR77,P01889,Q96EK5,Q02978,Q9UHX1,Q9NX14,Q13363,Q10713,O14936,O95202,P41227,Q7LGA3,Q9NRG9,P40939,P50542,Q05086,Q9UBM7,P78347,P53701,O75381,Q9Y5P6 24 +Ectropion 0.378114129611803 0.2626775243472886 0.7927991415778433 1.0 0.9470541781744372 11 P04062,P25054 2 +Low frustration tolerance 0.4192617445742705 0.2617794709061779 0.7934914671336588 1.0 0.9471951958809688 7 P04062 1 +Involuntary movements 0.2511141362485578 0.2614293925212064 0.7937613929831382 1.0 0.9471951958809688 274 P27544,P50897,P13073,P21912,O75306,O75027,P07196,O75845,P41440,O43924,Q9NR77,Q02978,Q9UHX1,P11166,O14773,Q14108,P35637,Q16637,O14949,Q13363,O76024,P55795,Q9BWD1,P05067,O14936,Q10713,P09651,O75503,Q8TD16,Q9NQZ5,O95202,O75298,Q96N66,Q99720,P22626,Q6P4A7,Q8NBU5,Q96IX5,Q9P0J0,Q15120,Q9UBX3,P04062,O60313,Q05086,Q9BUK6,Q5JRX3,Q9NZJ7,O96008,Q8N0X7,Q9H6K4,Q01105,P07602,O43681,Q9Y5P6,Q15233 55 +Overriding aorta 0.4185625463680826 0.2593408638530936 0.7953722528286225 1.0 0.9481090758817684 7 Q9NX14,P78347 2 +Broad ribs 0.4393696472016479 0.2578968539613512 0.7964865129316097 1.0 0.9485479548179871 4 P48651 1 +Demyelinating peripheral neuropathy 0.3448293227822333 0.2576822975942558 0.7966521093146854 1.0 0.9485479548179871 13 P41440,P19447,Q9NR77,P07196 4 +Irritability 0.2668677631687544 0.2548363727459447 0.7988494810971192 1.0 0.9498450485872952 71 P11166,P50897,P37268,Q15067,P21912,Q9NZJ7,O43772,P06737,P01889,P07602,Q8N1F7 11 +Inguinal hernia 0.274904478893589 0.2544088132353643 0.7991797429365044 1.0 0.9498450485872952 62 Q32P28,Q8NBU5,P21964,Q8NCH0,Q9NWM8,P08236,Q10713,Q9Y487,Q9UM00 9 +Abnormal phalangeal joint morphology of the hand 0.3010564237907911 0.2522987250639569 0.8008101735199944 1.0 0.950300385710665 28 Q9Y619,O75844,P41227,P16435,Q92917,P02545,O76024,P57740,P27635,Q99567 10 +Pes cavus 0.26110754053756 0.2507265323750108 0.8020255458956251 1.0 0.9508120831032584 84 Q13057,Q8TB36,P07196,Q9NR77,Q96BR5,P02545,P05023,Q10713,Q5T440,O00429,O75298,Q99720,P50570,Q7LGA3,Q15120,P40939,P50542,P04062,O60313,Q9BUK6,Q14739,Q9H0B6,Q8N0X7,Q9H6K4,O15269 25 +Olivopontocerebellar hypoplasia 0.4366790703382948 0.2499759900123863 0.8026059164832675 1.0 0.9508120831032584 4 Q9Y5P6 1 +Tinnitus 0.3752038515865679 0.2499708344706151 0.8026099034770229 1.0 0.9508120831032584 11 Q02978,Q9NR77 2 +Impaired t cell function 0.4063794144268268 0.2496725614949846 0.802840579054366 1.0 0.9508120831032584 8 P21964 1 +Broad nasal tip 0.2796841981981079 0.2495488889389171 0.80293622882383 1.0 0.9508120831032584 43 Q7LGA3,P25054,O43924,O14936,Q9Y487 5 +Mandibular prognathia 0.3005841995151401 0.2487436632884876 0.8035590716725967 1.0 0.9508815832601504 28 Q9NVI7,Q9BUK6,P48651,P25054,Q05086 5 +Abnormal circulating igm level 0.3747429610688542 0.2479722848068226 0.8041558507156044 1.0 0.9508815832601504 11 Q13724,Q9Y5L0,P50851,P13051,P00813 5 +Progressive leukoencephalopathy 0.3877700476016112 0.2478474575445946 0.8042524344044133 1.0 0.9508815832601504 3 Q5JTZ9,Q9Y263 2 +Vertebral hypoplasia 0.3853225791630978 0.2467176138725794 0.8051267739794361 1.0 0.9508815832601504 10 Q8TAA9,Q14739 2 +Abnormal circulating sex hormone concentration 0.3169853390484228 0.2465150315855957 0.8052835698857546 1.0 0.9508815832601504 17 Q13423,P49770,P16435,P57740,Q9NR50,P51809 6 +Fever 0.2615222100915517 0.2464091460262932 0.8053655269700473 1.0 0.9508815832601504 76 Q9HC07,O14936,Q8N1F7,Q14739,Q9NZJ7,P23786,P28070,Q9NR77,P51572,P01889,P61978,P07602,Q13546 13 +Slow saccadic eye movements 0.3851577655671024 0.2460454893613418 0.8056470192128506 1.0 0.9508815832601504 10 P04062 1 +Hyperkinetic movements 0.3954900852722891 0.2459134188016052 0.80574925604687 1.0 0.9508815832601504 9 Q9NZJ7 1 +Basal cell carcinoma 0.3741761345615051 0.2455195923584947 0.8060541398263963 1.0 0.9509913195428146 11 P02545,P19447,P25054 3 +Abnormal fingernail morphology 0.2791616107738945 0.2446284508617526 0.8067441326519238 1.0 0.9511026981835994 43 Q15125,O75431,Q14739 3 +Pancreatic cysts 0.3867218662377255 0.244567455398952 0.8067913657108763 1.0 0.9511026981835994 3 Q9NQH7 1 +Atrophy degeneration affecting the central nervous system 0.2474456406378586 0.2426534420431344 0.8082738774189444 1.0 0.9512012774236652 252 Q13057,P50897,P13073,O75306,O15118,P07196,O75845,O43924,P08236,Q9UHX1,P11166,Q96A33,P61960,P35637,O14773,Q16637,Q15165,Q99707,P55263,O76024,Q10713,P36507,P05067,O14936,P09651,O75503,Q9UM00,Q8TD16,O75298,Q86Y39,Q96N66,Q99720,P22626,Q8NBU5,Q16625,Q7LGA3,Q92917,Q92804,P04062,O60313,Q05086,Q9BT22,Q5JRX3,Q9NZJ7,O96008,Q01105,P43243,P07602,P51572,Q9Y5P6,P31483 51 +Supraventricular tachycardia 0.4341354696921118 0.2425765912917424 0.8083334170924101 1.0 0.9512012774236652 4 P02545,P41227 2 +Abnormal hair laboratory examination 0.4130797892888875 0.2404660767654374 0.8099689586285626 1.0 0.9523554326237854 7 P18074,P02545,Q9Y276,P19447 4 +Abnormal tricuspid valve morphology 0.3831856412993737 0.2380392016284309 0.8118506894091087 1.0 0.9543179397768674 10 P21964,Q15233 2 +Broad distal phalanx of finger 0.4204226288079028 0.2361591918698317 0.8133091441249376 1.0 0.9557819949810736 6 Q96L58 1 +Abnormal cardiac atrium morphology 0.2551073734465756 0.2336662841534586 0.8152440645317802 1.0 0.9570534558249096 120 Q8NCH0,P98175,P61978,Q16637,Q9NX14,P21964,P55263,P16435,Q13363,P42892,P55795,O75431,Q9UM00,O95202,Q96L58,Q9UBM7,O75844,Q9H267,Q15233 19 +Abnormality of the nasal alae 0.2553660171039362 0.2293231169468047 0.8186177874509606 1.0 0.9600095714867812 129 P98175,P25054,O75845,O43924,P61978,Q9Y487,Q9UHX1,P11166,Q15392,O60488,P16435,P55795,Q10713,P36507,O14936,O75431,Q16625,Q96L58,Q7LGA3,P04062,Q9NVI7,Q9UBM7,O75381 23 +Neoplasm of the skin 0.2864699994883811 0.2236424675085767 0.823035516207689 1.0 0.963502326793798 33 P53634,Q06136,P21912,P11802,P14324,P25054,P02545,P19447,P16615 9 +Delirium 0.3330893118594353 0.2230990109570535 0.8234584480993483 1.0 0.963502326793798 2 Q9UJS0 1 +High forehead 0.2695709801080601 0.2199587789976002 0.8259032580756829 1.0 0.9655258719050964 65 O95202,Q9NVI7,Q14739,Q7LGA3,P23786,P25054,Q13363,P36507,P50542,O75431,O75381,Q13555 12 +Abnormality of temperature regulation 0.2566826859784296 0.2175517331952633 0.8277783949828037 1.0 0.9674659991361518 92 Q9HC07,P23786,Q9NR77,P01889,P61978,Q13546,P36507,P00813,O14936,P50570,P28070,Q05086,Q8N1F7,Q8NFH4,Q14739,Q9NZJ7,O43772,P07602,P51572 19 +Inappropriate behavior 0.3181309758896872 0.2147850261801058 0.8299349278305179 1.0 0.9685736976620598 16 P07602,Q9NZJ7 2 +Abnormal metabolism 0.2788789463649198 0.2145201437559143 0.8301414601319739 1.0 0.9685736976620598 39 Q8N511,Q99707,P41440,P46977,Q9Y487,Q96EY8 6 +Purpura 0.3114130517139375 0.2136762482418703 0.8307995347253432 1.0 0.9689782515195792 17 P21964,Q8NCH0,P04062,P38435 4 +Abnormality of dental morphology 0.273521904960718 0.2130545936721549 0.8312843804829839 1.0 0.9692918419349524 47 Q96A33,Q9UBM7,Q96L58,Q7LGA3,Q9Y487 5 +Congenital diaphragmatic hernia 0.3100361102000411 0.2105582791296873 0.8332319708072566 1.0 0.9705541357339652 18 Q13363,O95202,Q9UBM7 3 +Spina bifida 0.3006014468363821 0.2086170171987349 0.8347472250586427 1.0 0.9715156801518674 24 P21964,O75845,Q8TAA9,Q9Y5P6,Q10713,Q9UHX1 6 +Gastritis 0.4108047205596956 0.2061586033658343 0.8366670229451274 1.0 0.9727848292176672 6 P50851,Q13546 2 +Nail dysplasia 0.2978691016939703 0.2058845857353956 0.8368810663122579 1.0 0.9727848292176672 26 Q13363,O95202,P42892,P16615 4 +Progressive pes cavus 0.420535096127214 0.2045236425583019 0.8379443183600757 1.0 0.9736429000755688 4 O75298 1 +Weak cry 0.4017480297421952 0.2029024914443072 0.8392112468973729 1.0 0.9742317837753258 7 P53007,O60313 2 +Pelvic kidney 0.4094251997575503 0.2019697207156133 0.8399403957212295 1.0 0.9743221752382728 6 Q9UHX1 1 +Antinuclear antibody positivity 0.4193159137629576 0.2012401811445572 0.8405107740974513 1.0 0.9743740517886044 4 Q13546 1 +Abnormal morphology of the radius 0.3636271731786223 0.2009635276297639 0.84072709296126 1.0 0.9743740517886044 11 Q96L58,Q32P28,P25054 3 +Abnormality of upper limb epiphysis morphology 0.3737075639820497 0.2005241790247085 0.8410706498727836 1.0 0.9743740517886044 10 Q13363,P16435 2 +Meningioma 0.4239036508910375 0.1987239563207608 0.8424786833236484 1.0 0.9752500208296452 5 P21912 1 +Arnold chiari malformation 0.3078966898032043 0.1979069829347391 0.8431178406473001 1.0 0.9753376240610416 18 O75845,Q8TAA9,P16435,Q15233 4 +Dilated cardiomyopathy 0.278122125770104 0.1971168439546441 0.8437361024511272 1.0 0.975445344424203 36 Q9H845,Q9NX14,P42167,O75306,P23786,P09493,P02545,O43819,P57740,P40939,Q9BQP7,Q16836 12 +Neuroendocrine neoplasm 0.3824005560289436 0.1970222661615796 0.8438101134077796 1.0 0.975445344424203 9 P21912,Q02978 2 +High palate 0.2488429498895285 0.1958631571248878 0.8447172750415128 1.0 0.975445344424203 173 Q9Y619,Q8NCH0,P21912,P98175,P23786,P25054,P07196,O75845,O43924,P40855,P61978,Q9Y487,Q99567,Q96A33,P16435,P02545,Q13363,P57740,P55795,P36507,O14936,O75431,Q5T440,Q9UM00,P49366,Q15125,Q8NBU5,Q16625,Q96L58,Q7LGA3,P48651,P50542,P04062,Q9BUK6,P62266,O75844,Q14671,Q01105,O75381,Q9Y5P6,Q15233 41 +Displacement of the urethral meatus 0.2519818430366538 0.1957155913296206 0.8448327802995297 1.0 0.975445344424203 100 Q9Y619,P37268,P40855,Q96EK5,Q9UHX1,Q9NX14,P21964,P16435,P02545,Q13363,P46783,O95453,O95202,P48651,Q9UBX3,P50542,Q9UBM7,O75844,P48449,P51809,O75381 21 +Inflammatory abnormality of the eye 0.2806619704101095 0.1956968049514797 0.8448474853386094 1.0 0.975445344424203 34 Q15800,P28070,P51648,Q14739 4 +Thoracic kyphoscoliosis 0.4072494075429074 0.1954225865029217 0.845062136003732 1.0 0.975445344424203 6 O75844,Q96J02 2 +Seborrheic dermatitis 0.4070856190443354 0.1949327054003382 0.8454456300879305 1.0 0.975445344424203 6 P21964 1 +Muscular dystrophy 0.3034277191872754 0.1948978680297258 0.8454729032553809 1.0 0.975445344424203 21 O14979,P50402,Q9Y5P6,P22626 4 +Abnormal paranasal sinus morphology 0.3078913452500895 0.1933384765892567 0.8466938947880216 1.0 0.9761935476197549 17 Q13432 1 +Thoracolumbar scoliosis 0.398606527319404 0.1928486633683594 0.8470774909013803 1.0 0.9761935476197549 7 Q93008,O95352,Q99575,P36776,P78318,P27635 6 +Hernia 0.2499245630655523 0.1919399678316358 0.847789229653471 1.0 0.9766114123934236 105 Q32P28,O95202,Q9UBM7,Q14739,P21964,Q8NCH0,Q8NBU5,Q9NWM8,Q13363,P08236,Q10713,O14936,Q9Y487,Q9UM00 14 +Craniofacial hyperostosis 0.4056194349146292 0.1905660934356966 0.8488655568327179 1.0 0.9769816545701008 6 Q96L58,P48651,P19447 3 +Intestinal polyp 0.3055557277757696 0.1902152030468005 0.8491404983017943 1.0 0.9769816545701008 19 P21912,P42892 2 +Patellar dislocation 0.3242726169586517 0.1880794694940635 0.8508143548573748 1.0 0.9783384126569044 14 Q15125 1 +Abnormal morphology of the abdominal musculature 0.4046670749198273 0.1877478148636871 0.8510743458617824 1.0 0.9783866967796312 6 Q8NCH0 1 +Abnormal iliac wing morphology 0.369872786140616 0.1858179404555272 0.8525875351020946 1.0 0.9798752516102948 10 Q8TAA9 1 +11 pairs of ribs 0.3960438815637532 0.1847669678257841 0.8534118175803347 1.0 0.9803205112107864 7 Q14739 1 +Abnormal penis morphology 0.2494361673920045 0.1831976283576442 0.8546429551743155 1.0 0.9805042386721464 160 Q8IWS0,P37268,P21912,O75845,Q96EK5,Q9UHX1,O95470,P21964,P16435,Q13363,P42892,Q10713,O14936,O95202,P48651,Q9UBX3,Q9NVI7,O75312,Q9UBM7,O75844,P48449,P46977,P51809,O75381,Q9Y5P6 25 +Abnormality of the urethra 0.2497680525576749 0.1830413585635336 0.8547655673382277 1.0 0.9805042386721464 107 Q9Y619,P37268,P40855,Q96EK5,P01889,Q9UHX1,Q9NX14,P21964,P16435,P02545,Q13363,P46783,O95453,O95202,P48651,Q9UBX3,P50542,Q9UBM7,P78347,O75844,P48449,P51809,O75381 23 +Skeletal myopathy 0.4179162407095357 0.1823989767178419 0.8552696287971817 1.0 0.9805042386721464 5 P21912 1 +Periorbital edema 0.2980129692512963 0.180460148755393 0.8567913374241223 1.0 0.9805042386721464 23 Q8NFH4,P78347,P28070,P57740,P50542,Q14C86,Q8N1F7 7 +Neurogenic bladder 0.3943641677705434 0.1795288316933458 0.8575224806589035 1.0 0.9805042386721464 7 Q8TAA9 1 +Red eye 0.3047017771376812 0.1792508491127337 0.8577407384165538 1.0 0.9805042386721464 18 P28070,Q14739 2 +Male pseudohermaphroditism 0.3639469415106304 0.1780652983700611 0.8586716943506456 1.0 0.9805042386721464 3 Q9NX14 1 +Hypodontia 0.2750474086494107 0.1769501064114003 0.8595475803408303 1.0 0.9805042386721464 38 Q15067,O75844,P25054,Q13363,O75431 5 +High anterior hairline 0.3048113732097172 0.1758307108274316 0.8604269417477548 1.0 0.9805042386721464 17 Q13363,Q7LGA3,O95202 3 +Abnormal ovarian physiology 0.3031338324296103 0.1757956986189359 0.8604544490174051 1.0 0.9805042386721464 19 O75844,P49770,P02545,Q5JTZ9,P57740,Q9NR50 6 +Abnormality of the auditory canal 0.304718956249004 0.1753095159628404 0.8608364349062494 1.0 0.9805042386721464 17 Q13363,P16435 2 +Fragile nails 0.3848888684556497 0.1750800951734352 0.8610166984407992 1.0 0.9805042386721464 8 P02545,P19447,Q9Y487,Q13555 4 +Abnormality of the neck 0.2517825039680213 0.1743047562310039 0.8616259615322517 1.0 0.9805042386721464 140 P25054,O96000,P08236,P61978,Q9Y487,P11166,P35637,P21964,Q13363,O75431,Q9UM00,Q15125,Q99720,Q96L58,Q7LGA3,Q9UBM7,Q14739,O75844,O75381 19 +Numerous pigmented freckles 0.3622978058788684 0.1736168314086661 0.8621666033642024 1.0 0.9805042386721464 3 P19447 1 +Concave nail 0.3622978058788684 0.1736168314086661 0.8621666033642024 1.0 0.9805042386721464 3 P19447 1 +Low set nipples 0.3622978058788684 0.1736168314086661 0.8621666033642024 1.0 0.9805042386721464 3 P19447 1 +Increased mean corpuscular hemoglobin concentration 0.3622978058788684 0.1736168314086661 0.8621666033642024 1.0 0.9805042386721464 3 P19447 1 +Abnormal mean corpuscular hemoglobin concentration 0.3622978058788684 0.1736168314086661 0.8621666033642024 1.0 0.9805042386721464 3 P19447 1 +Defective dna repair after ultraviolet radiation damage 0.3622978058788684 0.1736168314086661 0.8621666033642024 1.0 0.9805042386721464 3 P19447 1 +Bronchospasm 0.3622978058788684 0.1736168314086661 0.8621666033642024 1.0 0.9805042386721464 3 P19447 1 +Abnormality of dna repair 0.3622978058788684 0.1736168314086661 0.8621666033642024 1.0 0.9805042386721464 3 P19447 1 +Tiger tail banding 0.3622978058788684 0.1736168314086661 0.8621666033642024 1.0 0.9805042386721464 3 P19447 1 +Abnormal bronchus physiology 0.3622978058788684 0.1736168314086661 0.8621666033642024 1.0 0.9805042386721464 3 P19447 1 +Decreased circulating total igm 0.3997526828191547 0.1734335477955233 0.8623106573170594 1.0 0.9805042386721464 6 Q13724,P00813,P50851 3 +Abnormality of fibula morphology 0.3664575554153329 0.1729595242409778 0.8626832430369373 1.0 0.9806794312942692 10 O75431 1 +Jaundice 0.2692622336015732 0.1720733459006122 0.863379867080456 1.0 0.9811265932859592 47 P36551,P11166,P28288,Q14739,Q16625,Q9H9C1,O15118,Q6NUQ1,O14936,O75381,Q9H267 11 +Macrotia 0.2628072479121967 0.1717951348100555 0.8635985905196035 1.0 0.9811265932859592 68 P11166,Q8IWS0,P37268,Q8NCH0,Q7LGA3,P48651,P38159,P48449,Q01105,Q96EK5,O14936 11 +Areflexia 0.2599355714217633 0.1716248938177849 0.8637324353994709 1.0 0.9811265932859592 71 Q8TB36,P07196,P41440,Q9NR77,P61978,Q16637,Q15067,P02545,O60701,P05023,Q5T440,O00429,Q8TD16,P50570,Q15120,P50542,P40939,O60313,Q9BT22,O43819,Q9H6K4,O15269,O60231,P53007,Q9Y5P6 25 +Motor delay 0.2492676359080158 0.1686123418269773 0.8661015721893379 1.0 0.9823259681540936 190 Q8TB36,Q8NCH0,P21912,Q9NR77,P61978,Q9Y487,P35637,P16435,Q13363,Q10713,O14936,Q9UM00,Q8TD16,Q96N66,Q99720,Q96L58,Q7LGA3,Q9NWM8,Q15120,Q96J02,P40939,P04062,O60313,Q05086,Q9BUK6,Q9H0B6,Q8N0X7,P48449,Q01105,P06737,Q16836,Q9Y5P6,Q15233 33 +Impaired smooth pursuit 0.3261165963577931 0.1680569557696558 0.8665384719676654 1.0 0.9825731839795052 13 P41440,P46977 2 +Thoracic aortic aneurysm 0.2942537673308651 0.1657706789272611 0.8683374216519573 1.0 0.9843130105756468 24 O75844,Q96L58,Q7LGA3 3 +Abnormal cerebral artery morphology 0.319648465926619 0.1655495152377915 0.8685114799196885 1.0 0.9843130105756468 14 P05067 1 +Capillary malformation 0.3543885420492166 0.1637447187657603 0.8699321121516408 1.0 0.9851395370266908 11 Q9UIG0,Q8TD19,P78347,P41227,Q9Y5S9,P35250,Q9UQE7,Q15056,P42345,Q9UHX1 10 +Autoimmune antibody positivity 0.3728682992959963 0.1633356464767499 0.8702541689205854 1.0 0.9851395370266908 9 Q13546,Q96J02 2 +Abnormality of vitamin b metabolism 0.3532250527791408 0.1591837693339044 0.8735240910030586 1.0 0.98792151730654 11 P41440,Q96EY8 2 +Triangular mouth 0.4087717048635166 0.1584835075457762 0.8740758154952093 1.0 0.98792151730654 5 Q10713 1 +Generalized hyperreflexia 0.4085821509684867 0.1580010412593531 0.8744559782164425 1.0 0.98792151730654 5 P11166,P19447 2 +Thin eyebrow 0.3127655384788783 0.1561801137749001 0.8758910512838374 1.0 0.9889305756382044 15 Q15125,P48449,Q9UM00 3 +Cerebral visual impairment 0.2671333221291518 0.1556409999026807 0.8763160054840795 1.0 0.9891345724170796 49 Q96A33,Q96N66,P37268,Q9BSJ2,Q01105 5 +Esophageal neoplasm 0.39313427986998 0.1547730471026656 0.8770002404266726 1.0 0.9891345724170796 6 P21912 1 +Abnormal t cell morphology 0.3520360922144388 0.1545530227689162 0.8771737072682659 1.0 0.9891345724170796 11 P17812,Q13432,Q13546 3 +Facial edema 0.2922206828253446 0.1523250418833457 0.8789305748142779 1.0 0.9908667218705048 24 Q8NFH4,P78347,P28070,P57740,P50542,Q14C86,Q8N1F7 7 +Hip contracture 0.3603964971544909 0.1507113504128877 0.8802034191780739 1.0 0.991974061555024 10 Q7LGA3 1 +Hypoplasia of the corpus callosum 0.2477680602070969 0.1497300436850555 0.8809776039422093 1.0 0.991974061555024 159 P37268,P35606,O43924,P61978,O14936,Q9UM00,Q15125,Q96N66,Q7LGA3,Q9UBX3,P04062,Q05086,Q9UBM7,Q9NZJ7,Q9BSJ2,P48449,Q01105,P07602,Q15233 19 +Lumbar scoliosis 0.3981684981685001 0.1477959046865925 0.8825038414310844 1.0 0.9920980652121488 4 P36776,O95352,P27635 3 +Cystic liver disease 0.3515195898938118 0.1458146206648243 0.8840677336485903 1.0 0.9921029464523295 3 P14314,Q9UGP8 2 +Polycystic liver disease 0.3515195898938118 0.1458146206648243 0.8840677336485903 1.0 0.9921029464523295 3 P14314,Q9UGP8 2 +Hypoproteinemia 0.3067349926793468 0.145711747707699 0.8841489470272128 1.0 0.9921029464523295 2 Q9UJS0 1 +Abnormal macular morphology 0.2911011962523194 0.1449816983780137 0.8847253216853714 1.0 0.9921029464523295 24 P04062,P50897,P51648,P25054 4 +Hypoparathyroidism 0.3754869951924904 0.1449615793533998 0.8847412065401388 1.0 0.9921029464523295 8 P21964 1 +Upper limb undergrowth 0.3587168030926421 0.1446784691043259 0.8849647394428337 1.0 0.9921029464523295 10 P25054,Q14739 2 +Joint hypermobility 0.262809936856358 0.1442925613204582 0.8852694520461752 1.0 0.9921029464523295 65 Q8IWS0,P21964,Q96L58,Q7LGA3,P48651,Q9NWM8,Q8N0X7,Q01105,Q9Y487,Q05086,Q9UM00 11 +Dyskinesia 0.2680470196176213 0.1442029655737131 0.8853401992340153 1.0 0.9921029464523295 53 Q96N66,O75306,Q9UBX3,Q01105,O14936,P04062 6 +Abnormal palate morphology 0.2467076330862117 0.1439327605631349 0.8855535658395794 1.0 0.9921029464523295 231 Q8NCH0,P21912,P98175,P23786,P25054,P07196,O75845,O43924,P61978,Q9Y487,Q96A33,Q15392,P21964,P16435,Q13363,P55795,Q10713,O14936,O75431,Q9UM00,Q15125,O95202,Q8NBU5,Q96L58,Q7LGA3,P48651,Q9NWM8,P04062,Q9BUK6,Q9UBM7,Q14739,O75844,O75312,Q01105,O75381,Q9Y5P6,Q15233 37 +Peripheral axonal degeneration 0.2667607827566269 0.1419520845760077 0.8871178532839998 1.0 0.9927321278457174 58 Q13057,Q8TB36,Q9NVI7,Q15067,P22626,Q9H0B6,Q9NZJ7,P07196,P41440,O76024,O15269,Q8IV08,P09651,O60313,P07602 15 +Abnormal blood ion concentration 0.2673256424174977 0.1393836969486475 0.8891469545519204 1.0 0.9927321278457174 56 P36551,P11166,P21964,Q13423,P21912,P16930,P40939,Q9Y487,Q02978 9 +Aplasia hypoplasia of the extremities 0.2493768268539775 0.1378786701952229 0.8903363081048243 1.0 0.9927321278457174 143 Q32P28,Q8IWS0,P13073,P98175,P25054,Q96EK5,Q9UHX1,Q96A33,Q15392,O60488,P16435,Q13363,O14936,O75431,P38435,Q15125,O95202,Q96L58,Q7LGA3,P48651,Q13555,Q9UBM7,Q14739,O75844,Q8N0X7 25 +Abnormal blistering of the skin 0.2969573195355878 0.1352740514776499 0.8923952004005735 1.0 0.9930745498134824 18 P36551,Q06136 2 +Spinal rigidity 0.3319457242481056 0.1308960953899977 0.8958575035347125 1.0 0.9955451607261968 12 Q9Y5L0,P02545,Q9BQP7,P53007,P50402 5 +Steroid resistant nephrotic syndrome 0.3975131935470299 0.1307838742581247 0.895946279895969 1.0 0.9955451607261968 5 Q8N1F7 1 +Renal insufficiency 0.2598276886734986 0.1284223336283235 0.8978147578140869 1.0 0.9968787397497229 67 Q8NFH4,Q9BT22,Q14108,O95470,P78347,Q16625,O60488,P23786,Q8TAA9,Q10713,P01889,P16930,Q8N1F7 13 +Autophagic vacuoles 0.2994143484626551 0.1271987172643426 0.8987831206103662 1.0 0.9972756556658352 2 Q9Y5L0 1 +Abnormality of skeletal muscle fiber size 0.2958325812923589 0.1263775375273461 0.8994330820354186 1.0 0.9976392436926492 17 P09651,O60313,Q9BUK6,P22626 4 +Pes planus 0.2647435662088146 0.1259212059005334 0.8997942964050565 1.0 0.9976392436926492 59 P53634,Q96L58,Q9NWM8,Q9Y5P6,P55795,Q10713,P61978,Q9Y487,Q9UHX1,Q15233,Q9UM00 11 +Plantar hyperkeratosis 0.2719470485708383 0.1258742390672352 0.8998314747031737 1.0 0.9976392436926492 34 P53634,Q06136,P42167,P21912,P09493,P02545,P36507,O75431,P16615,O95453 10 +Thick upper lip vermilion 0.3682172748590269 0.122799816946319 0.9022656192194374 1.0 0.9993504686714796 8 O75845,P41227,Q08J23,P25054 4 +Gingival overgrowth 0.2875270116868338 0.1218327004297948 0.9030315156530035 1.0 0.9997413231149376 24 Q9UBM7,Q14739,O75845,P08236,Q9UM00 5 +Severe global developmental delay 0.2637175224834826 0.1211786779996486 0.9035495121404622 1.0 0.9997413231149376 48 Q96A33,Q9BT22,Q15067,Q7LGA3,P55263,O14936,O75381 7 +Basal ganglia calcification 0.3931876173770498 0.1206666750578952 0.9039550555259396 1.0 0.9997413231149376 5 O00429,O60313 2 +Abnormal circulating estrogen level 0.3596721164476008 0.1195820856169045 0.9048142114852348 1.0 1.0 9 P16435 1 +Morphological abnormality of the corticospinal tract 0.3151427069215138 0.1193893229830468 0.9049669198186738 1.0 1.0 13 O75298,P35637 2 +Abnormal urine metabolite level 0.2485294555296228 0.1189550371582824 0.9053109779175152 1.0 1.0 133 P36551,P21912,P23786,P25054,O96000,P08236,Q02978,Q14108,O95470,Q99707,P00367,P09601,P54802,O14936,O75431,Q96EY8,P40939,P04062,P16930,Q8N1F7,Q8NFH4,Q9H6K4,P06737,Q16836 24 +Allergy 0.3787322717522129 0.1167017193844774 0.9070964277163244 1.0 1.0 6 Q9Y5S9,P00813 2 +Corpus callosum atrophy 0.3141873890484273 0.1153019878763648 0.9082057627755756 1.0 1.0 13 P51572,O75503 2 +Aplasia hypoplasia of the hallux 0.308857291287935 0.1151583885184168 0.9083195803376554 1.0 1.0 14 Q13363,Q7LGA3,O95202 3 +Low hanging columella 0.3577591154161996 0.1135300345915781 0.909610352845839 1.0 1.0 9 P55795 1 +Hyperkalemia 0.3899979823881179 0.1133961154213052 0.9097165192934424 1.0 1.0 5 P11166 1 +Typical absence seizure 0.3496500549917818 0.1131439489722142 0.9099164324342752 1.0 1.0 10 P61978,Q01105 2 +Hydroureter 0.3647749957695191 0.1126597514472735 0.9103003117252172 1.0 1.0 8 Q7LGA3 1 +Short philtrum 0.2632420255371502 0.1126352224550577 0.9103197592478882 1.0 1.0 50 O95202,P21964,P25054,Q13363,P55795,Q96J02,O75431,Q15233 8 +Abnormal pulmonary valve physiology 0.2801227835733497 0.1123414338994024 0.910552690217511 1.0 1.0 29 O75306 1 +Neonatal hypotonia 0.2637649039810364 0.1117875230740983 0.9109918806560128 1.0 1.0 44 Q15067,Q96L58,P23786,O14936,Q16836,Q15233,Q9UM00 7 +Abnormal shape of the occiput 0.2918360823752937 0.1109126175727235 0.9116856399619072 1.0 1.0 19 P62266,Q96L58,Q96J02,P50542,O75381,Q05086 6 +Dyscalculia 0.3489160263361106 0.1106687327411574 0.9118790412938818 1.0 1.0 10 P35637,P22626 2 +Downturned corners of mouth 0.2798726154986519 0.1105909973120667 0.911940686797312 1.0 1.0 29 Q96A33,O95202,O75312,Q13363,P61978 5 +Abnormal shape of the palpebral fissure 0.3753353613233017 0.1082427981053639 0.9138030963932208 1.0 1.0 6 P55795 1 +Abnormal tricuspid valve physiology 0.2922967810537498 0.1075920771298387 0.9143192820416496 1.0 1.0 17 P40939,O75431,Q15233 3 +Apneic episodes precipitated by illness fatigue stress 0.2909956076134612 0.107551805824902 0.9143512285204484 1.0 1.0 2 P53007 1 +Food allergy 0.3346759428780667 0.1068845675853301 0.914880556332339 1.0 1.0 3 Q6P1M0,Q9Y5S9 2 +Abnormal respiratory system morphology 0.2410442991725251 0.1059013581135079 0.915660616510451 1.0 1.0 257 Q8NCH0,P98175,P25054,Q8TAA9,O96000,P08236,P17812,Q01844,P01889,Q9Y487,Q9UHX1,Q13546,Q14108,Q15392,P35637,Q16637,P21964,Q15165,P16435,Q13432,Q13363,P09601,P54802,P09651,P00813,Q86TI2,Q15125,P53634,O95202,Q96L58,Q7LGA3,Q92917,Q8IZA0,Q5JTZ9,P28070,Q92804,Q96J02,P04062,Q8N1F7,Q8NFH4,Q9UBM7,Q14739,O75844,Q9NZJ7,P43243,P07602 46 +Nystagmus induced head nodding 0.3791208791208814 0.1055824732308382 0.915913631348414 1.0 1.0 4 Q15056,P35250,P78347 3 +Phonophobia 0.3791208791208814 0.1055824732308382 0.915913631348414 1.0 1.0 4 Q15056,P35250,P78347 3 +Flat cornea 0.3791208791208814 0.1055824732308382 0.915913631348414 1.0 1.0 4 Q15056,P35250,P78347 3 +Overfriendliness 0.3791208791208814 0.1055824732308382 0.915913631348414 1.0 1.0 4 Q15056,P35250,P78347 3 +Distal lower limb amyotrophy 0.3117913232917486 0.1051598187340099 0.9162489938877764 1.0 1.0 13 Q8TD16,Q9NR77,Q15120,Q9H0B6 4 +Cubitus valgus 0.3253522688221207 0.104792631884355 0.916540356762785 1.0 1.0 12 P50542,P16435,P36507 3 +Abnormality of hindbrain morphology 0.2443384086284843 0.1047749190802181 0.9165544121619358 1.0 1.0 235 Q13057,P13073,P21912,P98175,P23786,O75845,P41440,Q8TAA9,O43924,Q8IV08,Q9Y487,P61960,O14773,Q14108,P35637,P16435,Q13363,P55795,Q10713,P36507,O14936,O75503,Q9UM00,Q15125,Q8TD16,O95202,Q99720,Q16625,Q92917,Q5JTZ9,O60313,Q92643,Q8NFH4,Q9BT22,Q9NVI7,Q9BUK6,Q9UBM7,O75312,P78347,Q5JRX3,Q8N0X7,Q14671,Q9H6K4,P46977,P51572,Q9Y5P6,Q15233 47 +Abnormal cortical bone morphology 0.325156186746109 0.1040331012833596 0.9171430800587572 1.0 1.0 12 P35606,Q86XL3 2 +Epistaxis 0.3111838586597678 0.1026136315784827 0.9182696235188128 1.0 1.0 13 P01889,P04062 2 +Ecchymosis 0.3379328870084234 0.1020319162918586 0.9187313417372318 1.0 1.0 11 Q8NCH0,P04062 2 +Abnormality of tibia morphology 0.3459138149276123 0.1006690733039187 0.9198131625502376 1.0 1.0 10 Q32P28 1 +Foot dorsiflexor weakness 0.2764446372562998 0.0984250658039633 0.9215947716774168 1.0 1.0 30 Q8TB36,Q99720,Q14739,Q96BR5,P07196,P02545,O15269,P46976,Q9NR77,P31483 10 +Abnormal labia minora morphology 0.3650777013165827 0.0961356728987498 0.9234128196290232 1.0 1.0 7 P16435 1 +Recurrent otitis media 0.2856019077799737 0.0956591996743442 0.923791246182644 1.0 1.0 22 Q14739,Q13432 2 +Mask like facies 0.3507430051371294 0.0919867510176517 0.926708566115166 1.0 1.0 9 P04062 1 +Cupped ribs 0.3679819024725747 0.0906283291357934 0.9277879211606752 1.0 1.0 6 Q96L58 1 +Renovascular hypertension 0.3792598021253136 0.0901175288219891 0.9281938199097252 1.0 1.0 5 P42224,Q15056,P35250,P78347 4 +Elfin facies 0.3792598021253136 0.0901175288219891 0.9281938199097252 1.0 1.0 5 Q9Y285,Q15056,P35250,P78347 4 +Supravalvular aortic stenosis 0.3792598021253135 0.0901175288219891 0.9281938199097252 1.0 1.0 5 P01130,Q15056,P35250,P78347 4 +Bilateral single transverse palmar creases 0.3342610348187975 0.0891165507766378 0.9289892841111312 1.0 1.0 11 P50542,O75381 2 +Neoplasm of the peripheral nervous system 0.3210336772443517 0.0882940260090229 0.929642986967455 1.0 1.0 12 P21912,Q02978 2 +Abnormal acetabulum morphology 0.2982070569858862 0.0863667258972303 0.9311748969542109 1.0 1.0 15 Q96L58,P08236 2 +Constriction of peripheral visual field 0.2869625634245301 0.084230220757158 0.9328733908686448 1.0 1.0 19 P50542,O75381,O60313,Q9H061 4 +Protruding ear 0.2641701938225393 0.0829873583590477 0.9338615915071488 1.0 1.0 35 Q06136,Q8NCH0,Q9BSJ2,P25054,P61978 5 +Atelectasis 0.3475501151799104 0.0825285904837902 0.934226383956972 1.0 1.0 9 P21964 1 +Chorioretinal atrophy 0.3672892611807886 0.0822883146635642 0.9344174464537598 1.0 1.0 4 P40939 1 +Hip subluxation 0.3589462449141699 0.0806709575071574 0.9357036340689626 1.0 1.0 7 Q96L58 1 +Highly arched eyebrow 0.2602243285449203 0.0806618303346082 0.9357108928438952 1.0 1.0 44 O95202,Q7LGA3,Q13363,O43924,Q10713,Q96EK5,Q13555,Q9UM00 8 +Abnormal platelet volume 0.3527718727684846 0.0791347633498635 0.9369254330500962 1.0 1.0 8 Q14739 1 +Irregular menstruation 0.3617375094188981 0.0764281652243992 0.9390784625239434 1.0 1.0 6 Q06787,P02545 2 +Atrophy degeneration involving the corticospinal tracts 0.3303856887492345 0.0758398507858394 0.9395465110617732 1.0 1.0 11 O75298,P35637 2 +Abnormality of the antihelix 0.3374826267166453 0.0736745592523612 0.9412693425357715 1.0 1.0 10 P98175,P16435,P27635 3 +Immunodeficiency 0.260229075641281 0.073395633397827 0.9414912922693874 1.0 1.0 52 Q96A33,O95202,Q9BT22,P21964,P21912,Q13432,Q13363,P17812,P09601 9 +Tetraplegia tetraparesis 0.2585581965896191 0.0733610126183115 0.9415188413874818 1.0 1.0 45 P35637,Q9NZJ7,Q9UBX3,P07602,O43681,P51572 6 +Mortality aging 0.2456321475109545 0.0720797269021818 0.9425384598416175 1.0 1.0 93 Q13057,O96000,Q15067,Q9NX14,Q9H0R6,P16435,P05067,O75431,Q96IX5,P50570,Q5JTZ9,Q6NUQ1,P50542,P04062,Q9BT22,Q9NVI7,Q14739,O75844,Q9NZJ7,P07602,O75381,Q9H267 22 +Speech apraxia 0.2850965970502085 0.0706304051539432 0.9436919110220164 1.0 1.0 17 Q8N0X7,Q7LGA3 2 +Incomplete penetrance 0.2777349283320586 0.0704617386886143 0.9438261529304182 1.0 1.0 26 P36551,P11166,P21912,O14979 4 +Degeneration of the lateral corticospinal tracts 0.3545673411463532 0.0700662531737726 0.9441409267311376 1.0 1.0 7 P35637 1 +Increased circulating igm level 0.3577712609970679 0.0677734982034706 0.9459659406121173 1.0 1.0 6 P49327,Q96AX1,Q9Y5L0,Q13043,P13051 5 +Abnormal vagina morphology 0.2894655254761208 0.0671723621209652 0.9464444872485328 1.0 1.0 16 P16435,Q9UBM7 2 +Expressive language delay 0.3564228589263911 0.064896038485523 0.9482567747776836 1.0 1.0 6 P21912 1 +Fine hair 0.3270655457659957 0.0647601070887582 0.948365004673532 1.0 1.0 11 P18074,P41227,Q08J23,P36507 4 +Granulocytopenia 0.3571428571428591 0.0641167904668734 0.9488772324950072 1.0 1.0 4 O75533,Q9Y4L1,P62857 3 +Sparse lateral eyebrow 0.346500034780526 0.0627780541270844 0.9499432416611122 1.0 1.0 8 P61978,Q92643 2 +Abnormal stomach morphology 0.2522406876244997 0.0624088228267656 0.9502372690581568 1.0 1.0 69 Q8NBU5,Q9UBM7,Q14739,Q8NCH0,P21912,P11802,O60488,P50570,P78347,P25054,O76024,P40855,P57740,P50542,P04062,O75381,Q13546 17 +Abnormal atrioventricular conduction 0.3123956105036045 0.0567748381898271 0.9547245578146716 1.0 1.0 12 P21912,O43772 2 +Cranial hyperostosis 0.3245251921331405 0.0564691763207057 0.9549680500625376 1.0 1.0 11 P22626,Q96L58,P48651,P19447,P09651 5 +Short palm 0.2952431738132808 0.0563497544037615 0.9550631834871616 1.0 1.0 14 Q9Y619,P48651,Q9UHX1,Q13555 4 +Abnormality of ocular smooth pursuit 0.2819938187163662 0.0558438143994562 0.9554662305376826 1.0 1.0 18 P41440,Q10713,P46977 3 +Papilloma 0.3373946808775568 0.0539198594882441 0.9569990140975508 1.0 1.0 9 P16615 1 +Dystrophic fingernails 0.3372934738639337 0.0536461997317432 0.9572170474201944 1.0 1.0 9 O75844,P02545,P19447,P36507 4 +Abnormal cerebellar vermis morphology 0.2555681668747928 0.0529386877545232 0.957780759228422 1.0 1.0 63 Q8NFH4,Q15125,Q9UBM7,P23786,O43924,Q10713,Q9Y487,Q9Y5P6,Q9UM00 9 +Hypoplasia of the uterus 0.3417844770520881 0.0510154130918812 0.9593132386695024 1.0 1.0 8 P11766,P57740,P53701,Q9NX14 4 +Abnormality of iron homeostasis 0.3584785916657156 0.0503878758628412 0.9598132977742876 1.0 1.0 5 Q9Y276,P28288 2 +Simplified gyral pattern 0.2743672845970387 0.0493665907281719 0.9606271524214992 1.0 1.0 26 O14936,Q86XL3 2 +Abnormal circulating phenylalanine concentration 0.3032876838622239 0.0492625413571765 0.9607100709209704 1.0 1.0 3 P35270 1 +Low posterior hairline 0.2742218180320903 0.0484665210941553 0.9613444453685298 1.0 1.0 26 Q13363,O95202,Q9UM00,P25054 4 +Retinal atrophy 0.2771806780898701 0.0470257366945839 0.9624927152995988 1.0 1.0 22 P04062,Q7LGA3,P51648 3 +Abnormal csf metabolite level 0.2554753453184915 0.046756777880414 0.9627070775858506 1.0 1.0 49 P11166,Q86Y39,P13073,Q9NX14,O75306,O96000,Q9Y6M9,Q7KZN9,O43676 9 +Increased csf lactate 0.256661132951941 0.0442173136408948 0.9647311812609742 1.0 1.0 43 Q86Y39,P13073,Q9NX14,O75306,O96000,Q9Y6M9,Q7KZN9,O43676 8 +Joint subluxation 0.3455027441753991 0.042809653735834 0.965853268477508 1.0 1.0 6 Q96L58 1 +Aggressive behavior 0.2564195707801949 0.0419237200255225 0.9665595071725954 1.0 1.0 59 Q15125,P11166,Q9UBM7,P54802,P55795,P51572,O75503,Q15233 8 +Abnormal magnesium concentration 0.352605637814765 0.0404361541836683 0.9677454069384992 1.0 1.0 5 Q15813,P05023 2 +Abnormality of pain sensation 0.2730305594947286 0.0329907531220526 0.9736819615686249 1.0 1.0 24 Q8NCH0,O15269,Q9NR77,P61978 4 +Self mutilation 0.3291677001950605 0.0324233334401658 0.9741344548739814 1.0 1.0 9 Q10713,Q9UBM7 2 +Hypergonadotropic hypogonadism 0.3052202666517884 0.0321507101865494 0.97435186340979 1.0 1.0 12 P48449 1 +Iris coloboma 0.2705896081466065 0.031920487802872 0.9745354600599478 1.0 1.0 27 O95202,Q9NX14,Q9UBM7,P41227,Q13363,Q9NRG9,Q10713,Q96EK5,Q9UHX1 9 +Restrictive ventilatory defect 0.328774238584484 0.0314334609871102 0.9749238563198463 1.0 1.0 9 Q96L58 1 +Neoplasm of the thyroid gland 0.2740808719623254 0.0298435506736119 0.9761918258059584 1.0 1.0 22 P21912,P42892 2 +Poor fine motor coordination 0.3383431085043993 0.0295053482710853 0.9764615534964742 1.0 1.0 6 P55072,Q06787,P42858,Q6PI48,O95140 5 +Truncal ataxia 0.2851579942987094 0.0294067393358846 0.9765401979177436 1.0 1.0 15 O75503 1 +Diffuse mesangial sclerosis 0.2764104204035367 0.0284976578666882 0.9772652360236088 1.0 1.0 17 Q8NFH4,O95470,P57740,P00813,Q14C86,Q8N1F7 6 +Abnormality of the dentition 0.2403954440402968 0.0284899182425175 0.9772714088438884 1.0 1.0 177 Q9HC07,P25054,P08236,P61978,Q9Y487,P51648,Q96A33,Q15067,P21964,Q13363,O75431,Q9UM00,Q15125,P53634,O95202,Q96L58,Q7LGA3,Q05086,Q9UBM7,Q14739,O75844,Q9BSJ2,Q8N0X7,Q01105,Q15233 25 +Akinesia 0.3318635022361893 0.0277872888862738 0.9778318040486174 1.0 1.0 8 P04062 1 +Bile duct proliferation 0.2860964606395115 0.0256972370105645 0.9794988276767962 1.0 1.0 3 Q5XKP0 1 +Increased circulating gonadotropin level 0.3263439151605877 0.0253970484902538 0.979738265313568 1.0 1.0 9 P16435 1 +Tetraplegia 0.3031175799653214 0.0252102225785415 0.9798872831101192 1.0 1.0 12 O43681,P51572 2 +Abnormal vena cava morphology 0.3307667047339643 0.0245787874411703 0.9803909393577792 1.0 1.0 4 P98175 1 +Dysgraphia 0.2908371995970229 0.0235254445710235 0.9812311422666262 1.0 1.0 13 P05067,O96008 2 +Protrusio acetabuli 0.2833590484218732 0.022437030179686 0.9820993419678028 1.0 1.0 3 O75718 1 +Syndactyly 0.2460148136639942 0.0224273544669715 0.9821070601274466 1.0 1.0 72 P11166,Q15125,P37268,Q9UBM7,P48651,P98175,P25054,O75845,O43924,Q96EK5,Q05086,Q9UHX1 12 +Craniosynostosis 0.2651627910699446 0.0216470273755806 0.982729519886914 1.0 1.0 30 P21964,Q8NCH0,Q96L58,P16435,P61978 5 +Abnormal labia morphology 0.2792485945794477 0.020936025258232 0.9832966889154192 1.0 1.0 16 Q9Y619,P51809,P16435 3 +Abnormality on pulmonary function testing 0.2825176120859853 0.0185791766822683 0.9851768145698974 1.0 1.0 15 P01889,Q96L58 2 +Hypoplasia of penis 0.2427582024909706 0.016365885037364 0.9869424958991702 1.0 1.0 84 Q8IWS0,O95470,Q9NVI7,Q9UBM7,O75312,P16435,O75845,P48449,P42892,Q10713,P46977,O14936,P51809,Q9Y5P6 14 +Narrow palpebral fissure 0.3171019306765639 0.0153333977455333 0.98776619806389 1.0 1.0 10 P38159 1 +Abnormal ilium morphology 0.2777122093214252 0.0143079390304814 0.9885843058500026 1.0 1.0 16 Q96L58,Q8TAA9 2 +Abnormal neural tube morphology 0.2623200979086328 0.0134568920446993 0.9892632776506164 1.0 1.0 31 P21964,Q99707,O75845,Q8TAA9,Q9Y5P6,Q10713,Q9UHX1 7 +Abnormal cranial nerve physiology 0.2545929957321791 0.0129478099402027 0.9896694309993624 1.0 1.0 55 P50542,P50570,P21912,O60488,P48651,Q9NZJ7,P07196,O75381,P02545,O43819,Q9Y5P6,P40855,Q9NR77,P01889,Q9BQP7,P53007,P07602,Q9UHX1 18 +Exercise induced myalgia 0.3209520467976579 0.0124845416601816 0.990039035720238 1.0 1.0 9 P50570,P43243,P23786 3 +Dysplastic corpus callosum 0.3159451441345284 0.012324242573881 0.990166926046618 1.0 1.0 10 Q15233 1 +Aplasia hypoplasia of the cerebellum 0.240249855600371 0.0122461038622932 0.9902292670135812 1.0 1.0 118 Q13057,P98175,P23786,O43924,Q9Y487,Q13363,P55795,Q10713,P36507,O14936,Q9UM00,Q15125,Q8TD16,O95202,Q16625,Q8NFH4,Q9NVI7,Q9BUK6,Q9UBM7,Q9Y5P6,Q15233 21 +Increased serum iron 0.273892347125595 0.0121500527436549 0.990305899016792 1.0 1.0 3 Q9Y276,Q6PGP7 2 +Abnormal aortic morphology 0.2422136793379538 0.0091244285620508 0.9927198603425742 1.0 1.0 83 Q9UBM7,O75844,Q96L58,P21964,Q7LGA3,Q9NWM8,P55263,P01889,P04062 9 +Abnormal toenail morphology 0.2534786960877863 0.007193062048008 0.9942608163380692 1.0 1.0 40 Q14739,P23786 2 +Abnormal liver physiology 0.3287942587680432 0.0057425132966461 0.9954181624825442 1.0 1.0 5 O75845 1 +Autistic behavior 0.2410083196764911 0.0043031373219936 0.9965666037637976 1.0 1.0 146 P21912,O75306,O96000,Q9Y6M9,P11166,Q15067,P21964,P55795,O14936,O75503,Q86Y39,Q96N66,Q7LGA3,Q05086,O43676,Q9BUK6,Q9UBM7,P48449,Q01105,Q15233 20 +Stage 5 chronic kidney disease 0.2676115960837048 0.0020702938957786 0.9983481456442408 1.0 1.0 24 Q8NFH4,O95470,Q14C86,P23786,P57740,Q92621,Q8N1F7 7 +Telangiectasia 0.2664767490342733 0.001937500143084 0.9984540995164743 1.0 1.0 26 O75306,Q14739 2 diff --git a/msigdb_hp/selections.json b/msigdb_hp/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..1159912872f841bc8df60377f94ef9bbafdfa8be --- /dev/null +++ b/msigdb_hp/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["11 pairs of ribs", "2 3 finger syndactyly", "2 3 toe cutaneous syndactyly", "2 3 toe syndactyly", "3 4 finger syndactyly", "3 methylglutaconic aciduria", "4 5 toe syndactyly", "Abdominal aortic aneurysm", "Abdominal distention", "Abdominal obesity", "Abdominal pain", "Abdominal wall muscle weakness", "Abducens palsy", "Abnormal 2nd finger morphology", "Abnormal 3rd finger morphology", "Abnormal 5th finger morphology", "Abnormal 5th finger phalanx morphology", "Abnormal abdomen morphology", "Abnormal acetabulum morphology", "Abnormal activity of mitochondrial respiratory chain", "Abnormal adipose tissue morphology", "Abnormal aggressive impulsive or violent behavior", "Abnormal aldolase level", "Abnormal anatomic location of the heart", "Abnormal anterior chamber morphology", "Abnormal anterior eye segment morphology", "Abnormal anterior horn cell morphology", "Abnormal aortic arch morphology", "Abnormal aortic morphology", "Abnormal aortic valve cusp morphology", "Abnormal aortic valve morphology", "Abnormal aortic valve physiology", "Abnormal arachnoid mater morphology", "Abnormal arm span", "Abnormal arterial physiology", "Abnormal astrocyte morphology", "Abnormal atrial arrangement", "Abnormal atrioventricular conduction", "Abnormal atrioventricular valve morphology", "Abnormal atrioventricular valve physiology", "Abnormal auditory evoked potentials", "Abnormal autonomic nervous system physiology", "Abnormal b cell morphology", "Abnormal b cell subset distribution", "Abnormal basal ganglia mri signal intensity", "Abnormal biliary tract morphology", "Abnormal bleeding", "Abnormal blistering of the skin", "Abnormal blood carbon dioxide level", "Abnormal blood chloride concentration", "Abnormal blood gas level", "Abnormal blood glucose concentration", "Abnormal blood inorganic cation concentration", "Abnormal blood ion concentration", "Abnormal blood monovalent inorganic cation concentration", "Abnormal blood phosphate concentration", "Abnormal blood potassium concentration", "Abnormal blood sodium concentration", "Abnormal blood transition element cation concentration", "Abnormal blood zinc concentration", "Abnormal bone structure", "Abnormal brain choline level by mrs", "Abnormal brain lactate level by mrs", "Abnormal brain n acetyl aspartate level by mrs", "Abnormal brain positron emission tomography", "Abnormal brainstem morphology", "Abnormal brainstem mri signal intensity", "Abnormal breath sound", "Abnormal bronchoalveolar lavage fluid morphology", "Abnormal bronchus morphology", "Abnormal bronchus physiology", "Abnormal c peptide level", "Abnormal c reactive protein level", "Abnormal calcification of the carpal bones", "Abnormal calcium phosphate regulating hormone level", "Abnormal cardiac atrium morphology", "Abnormal cardiac exercise stress test", "Abnormal cardiac septum morphology", "Abnormal cardiac test", "Abnormal cardiac ventricle morphology", "Abnormal cardiac ventricular function", "Abnormal cardiomyocyte morphology", "Abnormal carotid artery morphology", "Abnormal cartilage morphology", "Abnormal caudate nucleus morphology", "Abnormal cd4 cd8 ratio", "Abnormal cell morphology", "Abnormal cell proliferation", "Abnormal cellular composition of bronchoalveolar fluid", "Abnormal cellular phenotype", "Abnormal central sensory function", "Abnormal cerebellar vermis morphology", "Abnormal cerebral artery morphology", "Abnormal cerebral cortex morphology", "Abnormal cerebral vascular morphology", "Abnormal cerebral vein morphology", "Abnormal cerebral ventricle morphology", "Abnormal cerebrospinal fluid metabolite concentration", "Abnormal cervical curvature", "Abnormal cervical spine morphology", "Abnormal chorioretinal morphology", "Abnormal choroid morphology", "Abnormal choroid plexus morphology", "Abnormal chromosome morphology", "Abnormal ciliary body morphology", "Abnormal circulating acetylcarnitine concentration", "Abnormal circulating albumin concentration", "Abnormal circulating amino acid concentration", "Abnormal circulating amylase level", "Abnormal circulating androgen level", "Abnormal circulating apolipoprotein concentration", "Abnormal circulating arginine concentration", "Abnormal circulating aromatic amino acid concentration", "Abnormal circulating aspartate family amino acid concentration", "Abnormal circulating bilirubin concentration", "Abnormal circulating branched chain amino acid concentration", "Abnormal circulating carbohydrate concentration", "Abnormal circulating carboxylic acid concentration", "Abnormal circulating ceruloplasmin concentration", "Abnormal circulating cholesterol concentration", "Abnormal circulating citrulline concentration", "Abnormal circulating copper concentration", "Abnormal circulating creatinine concentration", "Abnormal circulating dehydroepiandrosterone concentration", "Abnormal circulating dicarboxylic acid concentration", "Abnormal circulating estrogen level", "Abnormal circulating fatty acid anion concentration", "Abnormal circulating fatty acid concentration", "Abnormal circulating ferritin concentration", "Abnormal circulating follicle stimulating hormone concentration", "Abnormal circulating free fatty acid concentration", "Abnormal circulating gaba concentration", "Abnormal circulating glutamine concentration", "Abnormal circulating glutamine family amino acid concentration", "Abnormal circulating glycine concentration", "Abnormal circulating gonadotropin concentration", "Abnormal circulating hormone concentration", "Abnormal circulating iga level", "Abnormal circulating ige level", "Abnormal circulating igg level", "Abnormal circulating igm level", "Abnormal circulating inhibin level", "Abnormal circulating lipid concentration", "Abnormal circulating long chain fatty acid concentration", "Abnormal circulating metabolite concentration", "Abnormal circulating methionine concentration", "Abnormal circulating monocarboxylic acid cocentration", "Abnormal circulating nitrogen compound concentration", "Abnormal circulating non proteinogenic amino acid concentration", "Abnormal circulating nucleobase concentration", "Abnormal circulating phenylalanine concentration", "Abnormal circulating porphyrin concentration", "Abnormal circulating progesterone level", "Abnormal circulating proline concentration", "Abnormal circulating protein concentration", "Abnormal circulating proteinogenic amino acid concentration", "Abnormal circulating proteinogenic amino acid derivative concentration", "Abnormal circulating pyruvate family amino acid concentration", "Abnormal circulating renin", "Abnormal circulating serine concentration", "Abnormal circulating serine family amino acid concentration", "Abnormal circulating sex hormone concentration", "Abnormal circulating sulfur amino acid concentration", "Abnormal circulating tyrosine concentration", "Abnormal clavicle morphology", "Abnormal cns myelination", "Abnormal cochlea morphology", "Abnormal conjugate eye movement", "Abnormal conjunctiva morphology", "Abnormal connection of the cardiac segments", "Abnormal consumption behavior", "Abnormal conus terminalis morphology", "Abnormal cornea morphology", "Abnormal corneal endothelium morphology", "Abnormal corneal epithelium morphology", "Abnormal coronary artery morphology", "Abnormal corpus callosum morphology", "Abnormal corpus striatum morphology", "Abnormal cortical bone morphology", "Abnormal cortical gyration", "Abnormal cranial nerve morphology", "Abnormal cranial nerve physiology", "Abnormal cry", "Abnormal csf carboxylic acid concentration", "Abnormal csf metabolite level", "Abnormal csf protein level", "Abnormal csf pyruvate family amino acid concentration", "Abnormal cutaneous elastic fiber morphology", "Abnormal delayed hypersensitivity skin test", "Abnormal delivery", "Abnormal dense granules", "Abnormal dental pulp morphology", "Abnormal dental root morphology", "Abnormal dentin morphology", "Abnormal dermatoglyphics", "Abnormal dermoepidermal junction morphology", "Abnormal descemet membrane morphology", "Abnormal diaphysis morphology", "Abnormal distal phalanx morphology of finger", "Abnormal dlco", "Abnormal drinking behavior", "Abnormal duodenum morphology", "Abnormal dura mater morphology", "Abnormal eating behavior", "Abnormal echocardiogram", "Abnormal elasticity of skin", "Abnormal electrophysiology of sinoatrial node origin", "Abnormal electroretinogram", "Abnormal emotion affect behavior", "Abnormal enchondral ossification", "Abnormal endocardium morphology", "Abnormal endocrine physiology", "Abnormal enzyme coenzyme activity", "Abnormal eosinophil morphology", "Abnormal epidermal morphology", "Abnormal epiglottis morphology", "Abnormal epiphyseal ossification", "Abnormal epiphysis morphology of the phalanges of the hand", "Abnormal erythrocyte enzyme level", "Abnormal erythrocyte morphology", "Abnormal erythrocyte physiology", "Abnormal erythrocyte sedimentation rate", "Abnormal esophagus morphology", "Abnormal esophagus physiology", "Abnormal external genitalia", "Abnormal exteroceptive sensation", "Abnormal eyebrow morphology", "Abnormal eyelash morphology", "Abnormal eyelid morphology", "Abnormal eyelid physiology", "Abnormal facial expression", "Abnormal facial shape", "Abnormal factor ix activity", "Abnormal fallopian tube morphology", "Abnormal fear anxiety related behavior", "Abnormal female reproductive system physiology", "Abnormal femoral head morphology", "Abnormal femoral neck head morphology", "Abnormal femoral neck morphology", "Abnormal finger phalanx morphology", "Abnormal fingernail morphology", "Abnormal fingertip morphology", "Abnormal foot bone ossification", "Abnormal foramen magnum morphology", "Abnormal forearm bone morphology", "Abnormal form of the vertebral bodies", "Abnormal foveal morphology", "Abnormal full field electroretinogram", "Abnormal fundus autofluorescence imaging", "Abnormal gallbladder morphology", "Abnormal gastrointestinal motility", "Abnormal glial cell morphology", "Abnormal globus pallidus morphology", "Abnormal glomerular basement membrane morphology", "Abnormal glomerular filtration rate", "Abnormal glomerular mesangial cellularity", "Abnormal glomerular mesangium morphology", "Abnormal glucose homeostasis", "Abnormal glycosylation", "Abnormal granulocyte count", "Abnormal granulocytopoietic cell morphology", "Abnormal greater sciatic notch morphology", "Abnormal growth hormone level", "Abnormal hair laboratory examination", "Abnormal hair morphology", "Abnormal hair pattern", "Abnormal hair quantity", "Abnormal hair whorl", "Abnormal hand bone ossification", "Abnormal hand morphology", "Abnormal hdl cholesterol concentration", "Abnormal head movements", "Abnormal heart rate variability", "Abnormal heart sound", "Abnormal heart valve morphology", "Abnormal heart valve physiology", "Abnormal hemoglobin", "Abnormal hemoglobin concentration", "Abnormal hepatic iron concentration", "Abnormal humerus morphology", "Abnormal hypothalamus morphology", "Abnormal hypothalamus physiology", "Abnormal ileum morphology", "Abnormal iliac wing morphology", "Abnormal ilium morphology", "Abnormal immune system morphology", "Abnormal incisor morphology", "Abnormal inflammatory response", "Abnormal insulin level", "Abnormal internal carotid artery morphology", "Abnormal internal genitalia", "Abnormal intestine morphology", "Abnormal intraocular pressure", "Abnormal involuntary eye movements", "Abnormal iris pigmentation", "Abnormal jaw morphology", "Abnormal jejunum morphology", "Abnormal joint morphology", "Abnormal labia majora morphology", "Abnormal labia minora morphology", "Abnormal labia morphology", "Abnormal lacrimal duct morphology", "Abnormal lacrimal gland morphology", "Abnormal lactate dehydrogenase level", "Abnormal large intestine morphology", "Abnormal large intestine physiology", "Abnormal larynx morphology", "Abnormal larynx physiology", "Abnormal lateral ventricle morphology", "Abnormal ldl cholesterol concentration", "Abnormal left atrium morphology", "Abnormal left ventricle morphology", "Abnormal left ventricular outflow tract morphology", "Abnormal length of corpus callosum", "Abnormal leukocyte count", "Abnormal leukocyte physiology", "Abnormal levels of alpha fetoprotein", "Abnormal libido", "Abnormal light and dark adapted electroretinogram", "Abnormal lip morphology", "Abnormal liver morphology", "Abnormal liver parenchyma morphology", "Abnormal liver physiology", "Abnormal localization of kidney", "Abnormal location of ears", "Abnormal lower limb bone morphology", "Abnormal lower motor neuron morphology", "Abnormal lumbar spine morphology", "Abnormal lung development", "Abnormal lung lobation", "Abnormal lymphatic vessel morphology", "Abnormal lymphocyte morphology", "Abnormal macrophage morphology", "Abnormal macroscopic urine appearance", "Abnormal macular morphology", "Abnormal magnesium concentration", "Abnormal male reproductive system physiology", "Abnormal mandibular ramus morphology", "Abnormal mean corpuscular hemoglobin concentration", "Abnormal mean corpuscular volume", "Abnormal megakaryocyte morphology", "Abnormal meningeal morphology", "Abnormal metabolic brain imaging by mrs", "Abnormal metabolism", "Abnormal metacarpal morphology", "Abnormal metaphyseal trabeculation", "Abnormal metatarsal morphology", "Abnormal midbrain morphology", "Abnormal middle phalanx morphology of the hand", "Abnormal mitochondria in muscle tissue", "Abnormal mitochondrial morphology", "Abnormal mitochondrial number", "Abnormal mitochondrial shape", "Abnormal mitral valve physiology", "Abnormal monocyte morphology", "Abnormal morphology of myocardial trabeculae", "Abnormal morphology of the abdominal musculature", "Abnormal morphology of the choroidal vasculature", "Abnormal morphology of the conjunctival vasculature", "Abnormal morphology of the great vessels", "Abnormal morphology of the limbic system", "Abnormal morphology of the musculature of the neck", "Abnormal morphology of the olfactory bulb", "Abnormal morphology of the radius", "Abnormal motor evoked potentials", "Abnormal motor nerve conduction velocity", "Abnormal muscle fiber alpha dystroglycan", "Abnormal muscle fiber morphology", "Abnormal muscle fiber protein expression", "Abnormal muscle fiber type distribution", "Abnormal muscle glycogen content", "Abnormal myelination", "Abnormal myeloid cell morphology", "Abnormal myeloid leukocyte morphology", "Abnormal myocardium morphology", "Abnormal nasal base", "Abnormal nasal bridge morphology", "Abnormal nasal mucosa morphology", "Abnormal nasolacrimal system morphology", "Abnormal natural killer cell morphology", "Abnormal natural killer cell physiology", "Abnormal nephron morphology", "Abnormal nerve conduction velocity", "Abnormal nervous system electrophysiology", "Abnormal neural tube morphology", "Abnormal neuron morphology", "Abnormal neutrophil count", "Abnormal nipple morphology", "Abnormal number of erythroid precursors", "Abnormal number of granulocyte precursors", "Abnormal number of incisors", "Abnormal number of permanent teeth", "Abnormal number of teeth", "Abnormal odontoid tissue morphology", "Abnormal optical coherence tomography", "Abnormal oral frenulum morphology", "Abnormal oral glucose tolerance", "Abnormal oral mucosa morphology", "Abnormal oral physiology", "Abnormal ossification involving the femoral head and neck", "Abnormal ovarian morphology", "Abnormal ovarian physiology", "Abnormal palate morphology", "Abnormal palmar dermatoglyphics", "Abnormal pancreas morphology", "Abnormal pancreas size", "Abnormal paranasal sinus morphology", "Abnormal parietal bone morphology", "Abnormal parotid gland morphology", "Abnormal patella morphology", "Abnormal pattern of respiration", "Abnormal pelvis bone morphology", "Abnormal pelvis bone ossification", "Abnormal penis morphology", "Abnormal pericardium morphology", "Abnormal peripheral action potential amplitude", "Abnormal peripheral myelination", "Abnormal peripheral nervous system morphology", "Abnormal peripheral nervous system physiology", "Abnormal peristalsis", "Abnormal periventricular white matter morphology", "Abnormal phalangeal joint morphology of the hand", "Abnormal pharynx morphology", "Abnormal pigmentation of the oral mucosa", "Abnormal pineal morphology", "Abnormal placenta morphology", "Abnormal placental membrane morphology", "Abnormal placental size", "Abnormal platelet aggregation", "Abnormal platelet function", "Abnormal platelet granules", "Abnormal platelet morphology", "Abnormal platelet volume", "Abnormal pleura morphology", "Abnormal pons morphology", "Abnormal posterior segment imaging", "Abnormal pr interval", "Abnormal preputium morphology", "Abnormal prolactin level", "Abnormal proportion of cd4 positive t cells", "Abnormal proportion of cd8 positive t cells", "Abnormal proportion of class switched memory b cells", "Abnormal proportion of double negative alpha beta regulatory t cell", "Abnormal prostate morphology", "Abnormal protein glycosylation", "Abnormal protein o linked glycosylation", "Abnormal proximal phalanx morphology of the hand", "Abnormal pulmonary interstitial morphology", "Abnormal pulmonary thoracic imaging finding", "Abnormal pulmonary valve morphology", "Abnormal pulmonary valve physiology", "Abnormal pupil morphology", "Abnormal pupillary function", "Abnormal pupillary light reflex", "Abnormal pyramidal sign", "Abnormal qrs complex", "Abnormal qt interval", "Abnormal rectum morphology", "Abnormal reflex", "Abnormal renal collecting system morphology", "Abnormal renal cortex morphology", "Abnormal renal corticomedullary differentiation", "Abnormal renal echogenicity", "Abnormal renal insterstitial morphology", "Abnormal renal medulla morphology", "Abnormal renal morphology", "Abnormal renal pelvis morphology", "Abnormal renal physiology", "Abnormal renal resorption", "Abnormal renal tubule morphology", "Abnormal renal vascular morphology", "Abnormal respiratory motile cilium morphology", "Abnormal respiratory motile cilium physiology", "Abnormal respiratory system morphology", "Abnormal response to acth stimulation test", "Abnormal response to endocrine stimulation test", "Abnormal response to insulin tolerance test", "Abnormal reticulocyte morphology", "Abnormal retinal artery morphology", "Abnormal retinal morphology", "Abnormal retinal vascular morphology", "Abnormal rib cage morphology", "Abnormal rib ossification", "Abnormal right atrium morphology", "Abnormal right ventricle morphology", "Abnormal saccadic eye movements", "Abnormal sacroiliac joint morphology", "Abnormal sacrum morphology", "Abnormal salivary gland morphology", "Abnormal sarcomere morphology", "Abnormal scalp morphology", "Abnormal scapula morphology", "Abnormal sclera morphology", "Abnormal scrotal rugation", "Abnormal sella turcica morphology", "Abnormal sensory nerve conduction velocity", "Abnormal serum insulin like growth factor 1 level", "Abnormal serum interferon level", "Abnormal serum interleukin level", "Abnormal serum iron concentration", "Abnormal sex determination", "Abnormal shape of the frontal region", "Abnormal shape of the occiput", "Abnormal shape of the palpebral fissure", "Abnormal sharpey fiber morphology", "Abnormal shoulder morphology", "Abnormal shoulder physiology", "Abnormal size of pituitary gland", "Abnormal size of the clitoris", "Abnormal size of the palpebral fissures", "Abnormal skin morphology of the palm", "Abnormal social behavior", "Abnormal soft palate morphology", "Abnormal speech prosody", "Abnormal sperm motility", "Abnormal spermatogenesis", "Abnormal spinal meningeal morphology", "Abnormal sputum", "Abnormal st segment", "Abnormal sternal ossification", "Abnormal sternum morphology", "Abnormal stomach morphology", "Abnormal stool composition", "Abnormal subarachnoid space morphology", "Abnormal subclavian artery morphology", "Abnormal subcutaneous fat tissue distribution", "Abnormal substantia nigra morphology", "Abnormal superior cerebellar peduncle morphology", "Abnormal sweat gland morphology", "Abnormal sweat homeostasis", "Abnormal synaptic transmission at the neuromuscular junction", "Abnormal systemic arterial morphology", "Abnormal systemic blood pressure", "Abnormal t cell activation", "Abnormal t cell morphology", "Abnormal t cell proliferation", "Abnormal t cell subset distribution", "Abnormal t wave", "Abnormal talus morphology", "Abnormal tarsal ossification", "Abnormal temper tantrums", "Abnormal temporal bone morphology", "Abnormal tendon morphology", "Abnormal testis morphology", "Abnormal thalamic mri signal intensity", "Abnormal thalamic size", "Abnormal thoracic spine morphology", "Abnormal thorax morphology", "Abnormal thrombocyte morphology", "Abnormal thrombosis", "Abnormal thumb morphology", "Abnormal thyroid hormone level", "Abnormal thyroid morphology", "Abnormal thyroid stimulating hormone level", "Abnormal tissue metabolite concentration", "Abnormal toenail morphology", "Abnormal tongue morphology", "Abnormal tongue physiology", "Abnormal trabecular bone morphology", "Abnormal tracheal morphology", "Abnormal tracheobronchial morphology", "Abnormal transferrin saturation", "Abnormal tricuspid valve morphology", "Abnormal tricuspid valve physiology", "Abnormal umbilicus morphology", "Abnormal upper limb bone morphology", "Abnormal upper motor neuron morphology", "Abnormal ureter morphology", "Abnormal ureter physiology", "Abnormal urinary color", "Abnormal urinary electrolyte concentration", "Abnormal urine alpha ketoglutarate concentration", "Abnormal urine carbohydrate level", "Abnormal urine carboxylic acid level", "Abnormal urine cytology", "Abnormal urine hormone level", "Abnormal urine magnesium concentration", "Abnormal urine metabolite level", "Abnormal urine ph", "Abnormal urine phosphate concentration", "Abnormal urine potassium concentration", "Abnormal urine protein level", "Abnormal urine sodium concentration", "Abnormal uterus morphology", "Abnormal uvea morphology", "Abnormal uvula morphology", "Abnormal vagina morphology", "Abnormal vascular morphology", "Abnormal vascular physiology", "Abnormal vena cava morphology", "Abnormal venous morphology", "Abnormal ventricular septum morphology", "Abnormal vertebral morphology", "Abnormal vertebral segmentation and fusion", "Abnormal vestibulo ocular reflex", "Abnormal visual electrophysiology", "Abnormal visual field test", "Abnormal visual fixation", "Abnormal vitamin b12 level", "Abnormal vitreous humor morphology", "Abnormal waist to hip ratio", "Abnormal z disc morphology", "Abnormalities of placenta or umbilical cord", "Abnormality iris morphology", "Abnormality of abdominal situs", "Abnormality of acid base homeostasis", "Abnormality of adrenal morphology", "Abnormality of adrenal physiology", "Abnormality of alkaline phosphatase level", "Abnormality of amino acid metabolism", "Abnormality of bladder morphology", "Abnormality of blood circulation", "Abnormality of blood volume homeostasis", "Abnormality of body mass index", "Abnormality of bone marrow cell morphology", "Abnormality of bone mineral density", "Abnormality of canine", "Abnormality of cardiovascular system electrophysiology", "Abnormality of carpal bone ossification", "Abnormality of cartilage of external ear", "Abnormality of central nervous system electrophysiology", "Abnormality of chorioretinal pigmentation", "Abnormality of chromosome segregation", "Abnormality of chromosome stability", "Abnormality of circulating adrenocorticotropin level", "Abnormality of circulating enzyme level", "Abnormality of circulating fibrinogen", "Abnormality of circulating glucocorticoid level", "Abnormality of circulating leptin level", "Abnormality of coagulation", "Abnormality of complement system", "Abnormality of coordination", "Abnormality of corneal size", "Abnormality of corneal stroma", "Abnormality of corneal thickness", "Abnormality of cranial sutures", "Abnormality of dental color", "Abnormality of dental eruption", "Abnormality of dental morphology", "Abnormality of dental structure", "Abnormality of dermal melanosomes", "Abnormality of digestive system morphology", "Abnormality of dna repair", "Abnormality of earlobe", "Abnormality of endocrine pancreas physiology", "Abnormality of epiphysis morphology", "Abnormality of exocrine pancreas physiology", "Abnormality of extrapyramidal motor function", "Abnormality of facial adipose tissue", "Abnormality of facial musculature", "Abnormality of facial skeleton", "Abnormality of facial soft tissue", "Abnormality of female external genitalia", "Abnormality of femur morphology", "Abnormality of fibula morphology", "Abnormality of finger", "Abnormality of fluid regulation", "Abnormality of folate metabolism", "Abnormality of fontanelles", "Abnormality of foveal pigmentation", "Abnormality of frontal sinus", "Abnormality of frontalis muscle belly", "Abnormality of fundus pigmentation", "Abnormality of globe location", "Abnormality of globe size", "Abnormality of glycolipid metabolism", "Abnormality of hair growth", "Abnormality of hair pigmentation", "Abnormality of hair texture", "Abnormality of hand joint mobility", "Abnormality of head blood vessel", "Abnormality of hepatobiliary system physiology", "Abnormality of hindbrain morphology", "Abnormality of humoral immunity", "Abnormality of immune serum protein physiology", "Abnormality of iron homeostasis", "Abnormality of krebs cycle metabolism", "Abnormality of limb epiphysis morphology", "Abnormality of lipoprotein cholesterol concentration", "Abnormality of long bone morphology", "Abnormality of lower limb epiphysis morphology", "Abnormality of lower limb joint", "Abnormality of lower limb metaphyses", "Abnormality of lower lip", "Abnormality of lysosomal metabolism", "Abnormality of macular pigmentation", "Abnormality of malar bones", "Abnormality of male internal genitalia", "Abnormality of metacarpal epiphyses", "Abnormality of metacarpophalangeal joint", "Abnormality of mouth shape", "Abnormality of mouth size", "Abnormality of muscle size", "Abnormality of nail color", "Abnormality of neuronal migration", "Abnormality of neutrophil morphology", "Abnormality of neutrophil physiology", "Abnormality of neutrophils", "Abnormality of ocular smooth pursuit", "Abnormality of pain sensation", "Abnormality of pancreas physiology", "Abnormality of pelvic girdle bone morphology", "Abnormality of periauricular region", "Abnormality of peripheral nerves", "Abnormality of prenatal development or birth", "Abnormality of primary teeth", "Abnormality of prothrombin", "Abnormality of pulmonary circulation", "Abnormality of refraction", "Abnormality of renal excretion", "Abnormality of renin angiotensin system", "Abnormality of reproductive system physiology", "Abnormality of retinal pigmentation", "Abnormality of salivation", "Abnormality of secondary sexual hair", "Abnormality of skeletal maturation", "Abnormality of skeletal muscle fiber size", "Abnormality of skin adnexa physiology", "Abnormality of skin physiology", "Abnormality of skin pigmentation", "Abnormality of skull ossification", "Abnormality of small intestinal villus morphology", "Abnormality of somatosensory evoked potentials", "Abnormality of subcutaneous fat tissue", "Abnormality of t cell physiology", "Abnormality of taste sensation", "Abnormality of temperature regulation", "Abnormality of thalamus morphology", "Abnormality of the 1st metacarpal", "Abnormality of the 2nd toe", "Abnormality of the 3rd toe", "Abnormality of the 4th metacarpal", "Abnormality of the 5th metacarpal", "Abnormality of the 5th toe", "Abnormality of the abdominal organs", "Abnormality of the abdominal wall", "Abnormality of the achilles tendon", "Abnormality of the adrenal glands", "Abnormality of the alveolar ridges", "Abnormality of the amniotic fluid", "Abnormality of the ankles", "Abnormality of the anterior fontanelle", "Abnormality of the antihelix", "Abnormality of the antitragus", "Abnormality of the anus", "Abnormality of the auditory canal", "Abnormality of the autonomic nervous system", "Abnormality of the axillary hair", "Abnormality of the basal ganglia", "Abnormality of the biliary system", "Abnormality of the bladder", "Abnormality of the brainstem white matter", "Abnormality of the breast", "Abnormality of the calcaneus", "Abnormality of the calf", "Abnormality of the calf musculature", "Abnormality of the calvaria", "Abnormality of the carpal bones", "Abnormality of the cerebral subcortex", "Abnormality of the cerebrospinal fluid", "Abnormality of the cervical spine", "Abnormality of the cheek", "Abnormality of the chin", "Abnormality of the choanae", "Abnormality of the clitoris", "Abnormality of the coagulation cascade", "Abnormality of the columella", "Abnormality of the common coagulation pathway", "Abnormality of the costochondral junction", "Abnormality of the crus of the helix", "Abnormality of the curvature of the cornea", "Abnormality of the curvature of the vertebral column", "Abnormality of the dentition", "Abnormality of the diaphragm", "Abnormality of the diencephalon", "Abnormality of the distal phalanges of the toes", "Abnormality of the distal phalanx of the thumb", "Abnormality of the dorsal column of the spinal cord", "Abnormality of the elbow", "Abnormality of the endometrium", "Abnormality of the epididymis", "Abnormality of the epiphyses of the distal phalanx of finger", "Abnormality of the external nose", "Abnormality of the extraocular muscles", "Abnormality of the extrinsic pathway", "Abnormality of the female genitalia", "Abnormality of the fetal cardiovascular system", "Abnormality of the fifth metatarsal bone", "Abnormality of the fontanelles or cranial sutures", "Abnormality of the foot musculature", "Abnormality of the forearm", "Abnormality of the forehead", "Abnormality of the frontal hairline", "Abnormality of the gallbladder", "Abnormality of the gastric mucosa", "Abnormality of the gingiva", "Abnormality of the glabella", "Abnormality of the glenoid fossa", "Abnormality of the hairline", "Abnormality of the hallux", "Abnormality of the helix", "Abnormality of the hepatic vasculature", "Abnormality of the humeroradial joint", "Abnormality of the humerus", "Abnormality of the hypothalamus pituitary axis", "Abnormality of the hypothenar eminence", "Abnormality of the incisor", "Abnormality of the inner ear", "Abnormality of the internal auditory canal", "Abnormality of the intervertebral disk", "Abnormality of the intrahepatic bile duct", "Abnormality of the intrinsic pathway", "Abnormality of the ischium", "Abnormality of the kidney", "Abnormality of the knee", "Abnormality of the larynx", "Abnormality of the lens", "Abnormality of the leydig cells", "Abnormality of the liver", "Abnormality of the lower urinary tract", "Abnormality of the lymph nodes", "Abnormality of the lymphatic system", "Abnormality of the mastoid", "Abnormality of the maxilla", "Abnormality of the menstrual cycle", "Abnormality of the metacarpal bones", "Abnormality of the metaphysis", "Abnormality of the metopic suture", "Abnormality of the middle ear", "Abnormality of the middle ear ossicles", "Abnormality of the middle phalanx of the 5th finger", "Abnormality of the midface", "Abnormality of the mitochondrion", "Abnormality of the musculature of the hand", "Abnormality of the musculature of the limbs", "Abnormality of the musculature of the lower limbs", "Abnormality of the musculature of the thigh", "Abnormality of the musculature of the upper arm", "Abnormality of the musculature of the upper limbs", "Abnormality of the nail", "Abnormality of the nasal alae", "Abnormality of the nasal bone", "Abnormality of the nasal cavity", "Abnormality of the nasal dorsum", "Abnormality of the nasal septum", "Abnormality of the nasal skeleton", "Abnormality of the nasal tip", "Abnormality of the nasolabial region", "Abnormality of the neck", "Abnormality of the odontoid process", "Abnormality of the optic nerve", "Abnormality of the outer ear", "Abnormality of the ovary", "Abnormality of the palm", "Abnormality of the palpebral fissures", "Abnormality of the pancreas", "Abnormality of the parathyroid gland", "Abnormality of the parathyroid morphology", "Abnormality of the periorbital region", "Abnormality of the peripheral nervous system", "Abnormality of the peritoneum", "Abnormality of the periungual region", "Abnormality of the phalanges of the hallux", "Abnormality of the phalanges of the toes", "Abnormality of the pharynx", "Abnormality of the philtrum", "Abnormality of the pineal gland", "Abnormality of the pinna", "Abnormality of the pituitary gland", "Abnormality of the plantar skin of foot", "Abnormality of the posterior pituitary", "Abnormality of the protein c anticoagulant pathway", "Abnormality of the proximal phalanx of the thumb", "Abnormality of the pubic bone", "Abnormality of the pubic hair", "Abnormality of the pulmonary artery", "Abnormality of the pulmonary vasculature", "Abnormality of the pulmonary veins", "Abnormality of the pylorus", "Abnormality of the radial head", "Abnormality of the radioulnar joints", "Abnormality of the ribs", "Abnormality of the scrotum", "Abnormality of the sense of smell", "Abnormality of the septum pellucidum", "Abnormality of the shoulder girdle musculature", "Abnormality of the skull base", "Abnormality of the small intestine", "Abnormality of the spinal cord", "Abnormality of the spleen", "Abnormality of the stapes", "Abnormality of the subungual region", "Abnormality of the supraorbital ridges", "Abnormality of the synovia", "Abnormality of the tarsal bones", "Abnormality of the temporomandibular joint", "Abnormality of the testis size", "Abnormality of the thenar eminence", "Abnormality of the thoracic cavity", "Abnormality of the thymus", "Abnormality of the thyroid gland", "Abnormality of the tongue", "Abnormality of the tongue muscle", "Abnormality of the tonsils", "Abnormality of the tragus", "Abnormality of the ulna", "Abnormality of the umbilical cord", "Abnormality of the upper arm", "Abnormality of the upper respiratory tract", "Abnormality of the ureter", "Abnormality of the urethra", "Abnormality of the urinary system physiology", "Abnormality of the uterus", "Abnormality of the vasculature of the eye", "Abnormality of the vertebral endplates", "Abnormality of the vestibulocochlear nerve", "Abnormality of the voice", "Abnormality of the wrist", "Abnormality of the zygomatic bone", "Abnormality of thyroid physiology", "Abnormality of tibia morphology", "Abnormality of toe", "Abnormality of ulnar metaphysis", "Abnormality of upper limb epiphysis morphology", "Abnormality of upper limb joint", "Abnormality of upper limb metaphysis", "Abnormality of upper lip", "Abnormality of upper lip vermillion", "Abnormality of urinary uric acid concentration", "Abnormality of urine calcium concentration", "Abnormality of urine catecholamine concentration", "Abnormality of urine homeostasis", "Abnormality of visual evoked potentials", "Abnormality of vitamin a metabolism", "Abnormality of vitamin b metabolism", "Abnormality of vitamin b12 metabolism", "Abnormality of vitamin d metabolism", "Abnormality of vitamin e metabolism", "Abnormality of vitamin k metabolism", "Abnormality of vitamin metabolism", "Abnormality on pulmonary function testing", "Abnormally folded helix", "Abnormally large globe", "Abnormally lax or hyperextensible skin", "Abnormally low pitched voice", "Abnormally ossified vertebrae", "Abnormally shaped carpal bones", "Abscess", "Absence of pubertal development", "Absence of secondary sex characteristics", "Absence of subcutaneous fat", "Absence of the sacrum", "Absent axillary hair", "Absent brainstem auditory responses", "Absent distal phalanges", "Absent earlobe", "Absent epiphyses", "Absent eyebrow", "Absent facial hair", "Absent fingernail", "Absent forearm bone", "Absent frontal sinuses", "Absent hair", "Absent hand", "Absent hypoplastic paranasal sinuses", "Absent nares", "Absent nipple", "Absent or minimally ossified vertebral bodies", "Absent outer dynein arms", "Absent palmar crease", "Absent septum pellucidum", "Absent shortened dynein arms", "Absent speech", "Absent sternal ossification", "Absent testis", "Absent thumb", "Absent thumbnail", "Absent toe", "Absent toenail", "Acanthocytosis", "Acantholysis", "Acanthosis nigricans", "Accelerated atherosclerosis", "Accelerated skeletal maturation", "Accessory oral frenulum", "Accessory spleen", "Acetabular dysplasia", "Achilles tendon contracture", "Acidemia", "Acne", "Acne inversa", "Acquired abnormal hair pattern", "Acral blistering", "Acral ulceration", "Acromesomelia", "Acroparesthesia", "Action tremor", "Acute coronary syndrome", "Acute encephalopathy", "Acute hepatic failure", "Acute kidney injury", "Acute leukemia", "Acute lymphoblastic leukemia", "Acute myeloid leukemia", "Acute pancreatitis", "Acute phase response", "Addictive behavior", "Adducted thumb", "Adenocarcinoma of the colon", "Adenocarcinoma of the intestines", "Adenocarcinoma of the small intestine", "Adenoma sebaceum", "Adenomatous colonic polyposis", "Adipose tissue loss", "Adrenal hyperplasia", "Adrenal hypoplasia", "Adrenal insufficiency", "Adrenal overactivity", "Adrenocortical abnormality", "Adrenocortical adenoma", "Adrenocortical carcinoma", "Adrenocorticotropic hormone deficiency", "Adrenocorticotropic hormone excess", "Adrenocorticotropin deficient adrenal insufficiency", "Adult onset", "Advanced eruption of teeth", "Advanced ossification of carpal bones", "Agammaglobulinemia", "Aganglionic megacolon", "Agenesis of central incisor", "Agenesis of cerebellar vermis", "Agenesis of corpus callosum", "Agenesis of incisor", "Agenesis of lateral incisor", "Agenesis of maxillary incisor", "Agenesis of permanent teeth", "Aggressive behavior", "Agitation", "Agnosia", "Agyria", "Airway obstruction", "Akinesia", "Alacrima", "Albinism", "Albuminuria", "Alexia", "Alkalosis", "Allergic rhinitis", "Allergy", "Alopecia", "Alopecia of scalp", "Alopecia totalis", "Alopecia universalis", "Alternating esotropia", "Alveolar cell carcinoma", "Alveolar rhabdomyosarcoma", "Alveolar ridge overgrowth", "Alzheimer disease", "Amaurosis fugax", "Ambiguous genitalia", "Ambiguous genitalia female", "Ambiguous genitalia male", "Amblyopia", "Amegakaryocytic thrombocytopenia", "Amelogenesis imperfecta", "Amenorrhea", "Aminoaciduria", "Amniotic constriction ring", "Amyloidosis", "Amyotrophic lateral sclerosis", "Anal atresia", "Anal stenosis", "Anarthria", "Anasarca", "Anemia of inadequate production", "Anencephaly", "Angina pectoris", "Angioedema", "Angiofibromas", "Angioid streaks of the fundus", "Angiokeratoma", "Angular cheilitis", "Anhidrosis", "Aniridia", "Anisocoria", "Anisocytosis", "Anisopoikilocytosis", "Anisospondyly", "Ankle clonus", "Ankle flexion contracture", "Ankle weakness", "Ankyloblepharon", "Ankyloglossia", "Ankylosis", "Annular pancreas", "Anodontia", "Anomalous trichromacy", "Anomic aphasia", "Anonychia", "Anophthalmia", "Anorectal anomaly", "Anorexia", "Anosmia", "Anotia", "Antenatal onset", "Anterior chamber synechiae", "Anterior open bite malocclusion", "Anterior pituitary dysgenesis", "Anterior plagiocephaly", "Anterior rib cupping", "Anterior synechiae of the anterior chamber", "Anterior uveitis", "Anteriorly placed anus", "Anteverted ears", "Anti thyroid peroxidase antibody positivity", "Antineutrophil antibody positivity", "Antinuclear antibody positivity", "Antiphospholipid antibody positivity", "Aortic aneurysm", "Aortic arch aneurysm", "Aortic atherosclerotic lesion", "Aortic dissection", "Aortic regurgitation", "Aortic root aneurysm", "Aortic valve calcification", "Aortic valve stenosis", "Aphasia", "Aphthous ulcer", "Aplasia cutis congenita", "Aplasia cutis congenita of scalp", "Aplasia cutis congenita on trunk or limbs", "Aplasia cutis congenita over the scalp vertex", "Aplasia hypoplasia affecting bones of the axial skeleton", "Aplasia hypoplasia affecting the anterior segment of the eye", "Aplasia hypoplasia affecting the eye", "Aplasia hypoplasia affecting the fundus", "Aplasia hypoplasia involving bones of the feet", "Aplasia hypoplasia involving bones of the lower limbs", "Aplasia hypoplasia involving bones of the thorax", "Aplasia hypoplasia involving bones of the upper limbs", "Aplasia hypoplasia involving forearm bones", "Aplasia hypoplasia involving the carpal bones", "Aplasia hypoplasia involving the femoral head and neck", "Aplasia hypoplasia involving the metacarpal bones", "Aplasia hypoplasia involving the musculature of the upper limbs", "Aplasia hypoplasia involving the nose", "Aplasia hypoplasia involving the pelvis", "Aplasia hypoplasia involving the sinuses", "Aplasia hypoplasia involving the skeletal musculature", "Aplasia hypoplasia involving the skeleton", "Aplasia hypoplasia involving the vertebral column", "Aplasia hypoplasia of fingers", "Aplasia hypoplasia of metatarsal bones", "Aplasia hypoplasia of the 4th metacarpal", "Aplasia hypoplasia of the 5th finger", "Aplasia hypoplasia of the 5th metacarpal", "Aplasia hypoplasia of the abdominal wall musculature", "Aplasia hypoplasia of the bladder", "Aplasia hypoplasia of the breasts", "Aplasia hypoplasia of the capital femoral epiphysis", "Aplasia hypoplasia of the cerebellar vermis", "Aplasia hypoplasia of the cerebellum", "Aplasia hypoplasia of the cerebral white matter", "Aplasia hypoplasia of the clavicles", "Aplasia hypoplasia of the colon", "Aplasia hypoplasia of the distal phalanges of the hand", "Aplasia hypoplasia of the distal phalanx of the thumb", "Aplasia hypoplasia of the ear", "Aplasia hypoplasia of the earlobes", "Aplasia hypoplasia of the epiglottis", "Aplasia hypoplasia of the extremities", "Aplasia hypoplasia of the eyebrow", "Aplasia hypoplasia of the eyelid", "Aplasia hypoplasia of the femur", "Aplasia hypoplasia of the fibula", "Aplasia hypoplasia of the gallbladder", "Aplasia hypoplasia of the hallux", "Aplasia hypoplasia of the humerus", "Aplasia hypoplasia of the lungs", "Aplasia hypoplasia of the nails", "Aplasia hypoplasia of the nasal bone", "Aplasia hypoplasia of the nasal septum", "Aplasia hypoplasia of the nipples", "Aplasia hypoplasia of the optic nerve", "Aplasia hypoplasia of the ovary", "Aplasia hypoplasia of the palmar creases", "Aplasia hypoplasia of the patella", "Aplasia hypoplasia of the phalanges of the hand", "Aplasia hypoplasia of the phalanges of the thumb", "Aplasia hypoplasia of the phalanges of the toes", "Aplasia hypoplasia of the proximal phalanges of the hand", "Aplasia hypoplasia of the pubic bone", "Aplasia hypoplasia of the radius", "Aplasia hypoplasia of the retina", "Aplasia hypoplasia of the ribs", "Aplasia hypoplasia of the sacrum", "Aplasia hypoplasia of the scapulae", "Aplasia hypoplasia of the skin", "Aplasia hypoplasia of the spleen", "Aplasia hypoplasia of the sternum", "Aplasia hypoplasia of the thumb", "Aplasia hypoplasia of the thymus", "Aplasia hypoplasia of the thyroid gland", "Aplasia hypoplasia of the tibia", "Aplasia hypoplasia of the tongue", "Aplasia hypoplasia of the tragus", "Aplasia hypoplasia of the ulna", "Aplasia hypoplasia of the uterus", "Aplasia hypoplasia of the uvula", "Aplasia hypoplasia of the vagina", "Aplasia hypoplasia of toe", "Aplasia involving bones of the extremities", "Aplasia involving bones of the lower limbs", "Aplasia of the fingers", "Aplasia of the middle phalanx of the hand", "Aplasia of the phalanges of the hand", "Aplasia of the phalanges of the toes", "Aplasia of the uterus", "Aplastic anemia", "Aplastic clavicle", "Aplastic hypoplastic lacrimal glands", "Aplastic hypoplastic toenail", "Apnea", "Apneic episodes precipitated by illness fatigue stress", "Appendicular hypotonia", "Apraxia", "Aqueductal stenosis", "Arachnodactyly", "Arachnoid hemangiomatosis", "Areflexia", "Areflexia of lower limbs", "Arm dystonia", "Arnold chiari malformation", "Arnold chiari type i malformation", "Arrhinencephaly", "Arteria lusoria", "Arterial dissection", "Arterial rupture", "Arterial stenosis", "Arterial thrombosis", "Arteriosclerosis", "Arteriovenous malformation", "Arthralgia", "Arthritis", "Arthrogryposis multiplex congenita", "Arthropathy", "Ascending aortic dissection", "Ascending tubular aorta aneurysm", "Ascites", "Aspiration", "Aspiration pneumonia", "Asterixis", "Asthenia", "Asthma", "Astigmatism", "Astrocytoma", "Astrocytosis", "Asymmetric growth", "Asymmetric septal hypertrophy", "Asymmetry of spinal facet joints", "Asymmetry of the ears", "Asymmetry of the thorax", "Atelectasis", "Athetosis", "Atlantoaxial abnormality", "Atlantoaxial dislocation", "Atlantoaxial instability", "Atonic seizure", "Atopic dermatitis", "Atresia of the external auditory canal", "Atrial arrhythmia", "Atrial flutter", "Atrioventricular canal defect", "Atrophic scars", "Atrophy degeneration affecting the brainstem", "Atrophy degeneration affecting the central nervous system", "Atrophy degeneration affecting the cerebrum", "Atrophy degeneration involving the caudate nucleus", "Atrophy degeneration involving the corticospinal tracts", "Atrophy degeneration involving the spinal cord", "Atrophy of alveolar ridges", "Attention deficit hyperactivity disorder", "Attenuation of retinal blood vessels", "Atypical absence seizure", "Auditory hallucinations", "Autism", "Autistic behavior", "Autoamputation", "Autoamputation of digits", "Autoimmune antibody positivity", "Autoimmune hemolytic anemia", "Autoimmune thrombocytopenia", "Autoimmunity", "Autophagic vacuoles", "Autosomal dominant germline de novo mutation", "Avascular necrosis", "Avascular necrosis of the capital femoral epiphysis", "Axial dystonia", "Axial muscle weakness", "Axillary pterygium", "Axonal degeneration", "Axonal degeneration regeneration", "Axonal loss", "Axonal regeneration", "Azoospermia", "B cell lymphoma", "B lymphocytopenia", "Babinski sign", "Back pain", "Bacterial endocarditis", "Barrel shaped chest", "Barrett esophagus", "Basal cell carcinoma", "Basal ganglia calcification", "Basal ganglia cysts", "Basal ganglia gliosis", "Basilar invagination", "Beaded ribs", "Beaking of vertebral bodies", "Bell shaped thorax", "Benign neoplasm of the central nervous system", "Biconcave vertebral bodies", "Bicornuate uterus", "Bifid nasal tip", "Bifid ribs", "Bifid scrotum", "Bifid tongue", "Bifid uterus", "Bifid uvula", "Bilateral camptodactyly", "Bilateral cleft lip", "Bilateral cleft lip and palate", "Bilateral cleft palate", "Bilateral coxa valga", "Bilateral cryptorchidism", "Bilateral external ear deformity", "Bilateral microphthalmos", "Bilateral polymicrogyria", "Bilateral ptosis", "Bilateral sensorineural hearing impairment", "Bilateral single transverse palmar creases", "Bilateral talipes equinovarus", "Bilateral tonic clonic seizure", "Bilateral tonic clonic seizure with focal onset", "Bilateral tonic clonic seizure with generalized onset", "Bile duct proliferation", "Biliary atresia", "Biliary cirrhosis", "Biliary tract abnormality", "Biliary tract neoplasm", "Biparietal narrowing", "Bird like facies", "Birth length greater than 97th percentile", "Birth length less than 3rd percentile", "Biventricular hypertrophy", "Bladder diverticulum", "Bladder neoplasm", "Bleeding with minor or no trauma", "Blepharitis", "Blepharophimosis", "Blindness", "Blistering by anatomical location", "Blistering by histological location", "Bloodstream infectious agent", "Bloody diarrhea", "Blue irides", "Blue nevus", "Blue sclerae", "Blurred vision", "Bone cyst", "Bone fracture", "Bone marrow foam cells", "Bone marrow hypercellularity", "Bone marrow hypocellularity", "Bone pain", "Bone spicule pigmentation of the retina", "Bowel diverticulosis", "Bowing of the arm", "Bowing of the legs", "Brachycephaly", "Brachydactyly", "Brachyturricephaly", "Bradycardia", "Bradykinesia", "Brain imaging abnormality", "Brain neoplasm", "Brain stem compression", "Branchial anomaly", "Branchial cyst", "Branchial fistula", "Breast aplasia", "Breast carcinoma", "Breast hypoplasia", "Breathing dysregulation", "Breech presentation", "Brisk reflexes", "Brittle hair", "Broad alveolar ridges", "Broad based gait", "Broad clavicles", "Broad columella", "Broad distal phalanx of finger", "Broad eyebrow", "Broad face", "Broad femoral neck", "Broad finger", "Broad foot", "Broad forehead", "Broad hallux phalanx", "Broad jaw", "Broad long bones", "Broad metacarpals", "Broad nail", "Broad nasal tip", "Broad neck", "Broad palm", "Broad phalanx of the toes", "Broad philtrum", "Broad ribs", "Broad thumb", "Broad toe", "Bronchiectasis", "Bronchitis", "Bronchomalacia", "Bronchospasm", "Bruising susceptibility", "Brushfield spots", "Bruxism", "Bulbar palsy", "Bulbar signs", "Bulbous nose", "Bull s eye maculopathy", "Bundle branch block", "Burkitt lymphoma", "Butterfly vertebrae", "Cachexia", "Caesarian section", "Cafe au lait spot", "Calcific stippling", "Calcification of cartilage", "Calcification of the aorta", "Calcinosis", "Calcium nephrolithiasis", "Calcium oxalate nephrolithiasis", "Calf muscle pseudohypertrophy", "Calvarial hyperostosis", "Calvarial osteosclerosis", "Calvarial skull defect", "Camptodactyly of toe", "Capillary hemangioma", "Capillary malformation", "Capitate hamate fusion", "Carcinoid tumor", "Carcinoma", "Cardiac arrest", "Cardiac conduction abnormality", "Cardiac diverticulum", "Cardiac shunt", "Cardiac valve calcification", "Cardiomegaly", "Cardiorespiratory arrest", "Cardiovascular calcification", "Carious teeth", "Carpal bone hypoplasia", "Carpal synostosis", "Cataplexy", "Caudate atrophy", "Cavernous hemangioma", "Cavum septum pellucidum", "Celiac disease", "Cellular immunodeficiency", "Cellulitis", "Central adrenal insufficiency", "Central apnea", "Central diabetes insipidus", "Central hypothyroidism", "Central hypoventilation", "Central nervous system cyst", "Central opacification of the cornea", "Central primitive neuroectodermal tumor", "Central scotoma", "Central sleep apnea", "Central y shaped metacarpal", "Centrally nucleated skeletal muscle fibers", "Centrocecal scotoma", "Cerebellar atrophy", "Cerebellar cortical atrophy", "Cerebellar cyst", "Cerebellar dysplasia", "Cerebellar hemorrhage", "Cerebellar hypoplasia", "Cerebellar malformation", "Cerebellar vermis atrophy", "Cerebral amyloid angiopathy", "Cerebral calcification", "Cerebral cortical atrophy", "Cerebral dysmyelination", "Cerebral edema", "Cerebral hamartoma", "Cerebral hemorrhage", "Cerebral hypomyelination", "Cerebral hypoplasia", "Cerebral inclusion bodies", "Cerebral palsy", "Cerebral venous thrombosis", "Cerebral visual impairment", "Cerebral white matter atrophy", "Cerebral white matter hypoplasia", "Cervical kyphosis", "Cervical myelopathy", "Cervical ribs", "Cervical spinal canal stenosis", "Cervical spine instability", "Cervical subluxation", "Cessation of head growth", "Cheilitis", "Cherry red spot of the macula", "Chest pain", "Chilblains", "Childhood onset", "Childhood onset sensorineural hearing impairment", "Childhood onset truncal obesity", "Chills", "Choanal stenosis", "Choking episodes", "Cholangiocarcinoma", "Cholangitis", "Cholecystitis", "Cholestasis", "Cholestatic liver disease", "Chondrocalcinosis", "Chondrosarcoma", "Chordee", "Chorea", "Choreoathetosis", "Choriocarcinoma", "Chorioretinal atrophy", "Chorioretinal coloboma", "Chorioretinal degeneration", "Chorioretinal dysplasia", "Chorioretinal hypopigmentation", "Choroid plexus carcinoma", "Choroid plexus cyst", "Choroidal melanoma", "Choroidal neovascularization", "Chromosomal breakage induced by crosslinking agents", "Chromosomal breakage induced by ionizing radiation", "Chromosome breakage", "Chronic atrophic gastritis", "Chronic axonal neuropathy", "Chronic bronchitis", "Chronic constipation", "Chronic diarrhea", "Chronic fatigue", "Chronic hemolytic anemia", "Chronic hepatic failure", "Chronic infection", "Chronic kidney disease", "Chronic leukemia", "Chronic lung disease", "Chronic lymphatic leukemia", "Chronic mucocutaneous candidiasis", "Chronic neutropenia", "Chronic noninfectious lymphadenopathy", "Chronic oral candidiasis", "Chronic otitis media", "Chronic pulmonary obstruction", "Chronic rhinitis", "Chronic sinusitis", "Chylothorax", "Cigarette paper scars", "Cirrhosis", "Cleft hard palate", "Cleft lip", "Cleft soft palate", "Cleft upper lip", "Clinodactyly", "Clitoral hypoplasia", "Clonic seizure", "Clonus", "Cloverleaf skull", "Clubbing", "Clubbing of fingers", "Clubbing of toes", "Clumsiness", "Cns demyelination", "Cns hypomyelination", "Coarctation of aorta", "Coarse facial features", "Coarse hair", "Cochlear malformation", "Cognitive impairment", "Cogwheel rigidity", "Cold induced muscle cramps", "Colitis", "Collectionism", "Coloboma", "Colon cancer", "Color vision defect", "Color vision test abnormality", "Colorectal polyposis", "Colpocephaly", "Coma", "Combined immunodeficiency", "Communicating hydrocephalus", "Complete atrioventricular canal defect", "Complete duplication of phalanx of hand", "Complex febrile seizure", "Concave nail", "Concave nasal ridge", "Concentric hypertrophic cardiomyopathy", "Cone cone rod dystrophy", "Cone shaped epiphyses of the phalanges of the hand", "Cone shaped epiphysis", "Confetti like hypopigmented macules", "Confusion", "Congenital adrenal hyperplasia", "Congenital bilateral hip dislocation", "Congenital blindness", "Congenital contracture", "Congenital craniofacial dysostosis", "Congenital diaphragmatic hernia", "Congenital hemolytic anemia", "Congenital hepatic fibrosis", "Congenital hip dislocation", "Congenital hypothyroidism", "Congenital ichthyosiform erythroderma", "Congenital localized absence of skin", "Congenital malformation of the great arteries", "Congenital malformation of the left heart", "Congenital malformation of the right heart", "Congenital muscular dystrophy", "Congenital muscular torticollis", "Congenital nonbullous ichthyosiform erythroderma", "Congenital nystagmus", "Congenital onset", "Congenital posterior urethral valve", "Congenital sensorineural hearing impairment", "Congenital stationary night blindness", "Congenital thrombocytopenia", "Congestive heart failure", "Conical tooth", "Conjugated hyperbilirubinemia", "Conjunctival hamartoma", "Connective tissue nevi", "Conspicuously happy disposition", "Constipation", "Constitutional symptom", "Constriction of peripheral visual field", "Contiguous gene syndrome", "Contractures involving the joints of the feet", "Contractures of the joints of the lower limbs", "Contractures of the joints of the upper limbs", "Contractures of the large joints", "Convex nasal ridge", "Coombs positive hemolytic anemia", "Cor pulmonale", "Corneal dystrophy", "Corneal erosion", "Corneal neovascularization", "Corneal opacity", "Corneal scarring", "Corneal ulceration", "Coronal cleft vertebrae", "Coronal craniosynostosis", "Coronary artery aneurysm", "Coronary artery atherosclerosis", "Corpus callosum atrophy", "Cortical cataract", "Cortical dysplasia", "Cortical myoclonus", "Cortical thickening of long bone diaphyses", "Corticospinal tract hypoplasia", "Cough", "Coxa valga", "Coxa vara", "Crackles", "Cranial asymmetry", "Cranial hyperostosis", "Cranial nerve compression", "Craniofacial asymmetry", "Craniofacial dysostosis", "Craniofacial hyperostosis", "Craniofacial osteosclerosis", "Craniosynostosis", "Crossed fused renal ectopia", "Crumpled long bones", "Cryptorchidism", "Csf lymphocytic pleiocytosis", "Csf pleocytosis", "Cubitus valgus", "Cupped ear", "Cupped ribs", "Curly eyelashes", "Curly hair", "Cutaneous abscess", "Cutaneous amyloidosis", "Cutaneous cyst", "Cutaneous finger syndactyly", "Cutaneous melanoma", "Cutaneous photosensitivity", "Cutaneous syndactyly", "Cutaneous syndactyly of toes", "Cutis laxa", "Cutis marmorata", "Cyanosis", "Cyanotic episode", "Cyclopia", "Cystic hygroma", "Cystic liver disease", "Cystic renal dysplasia", "Cystinuria", "Cystoid macular edema", "Cytochrome c oxidase negative muscle fibers", "Dark urine", "Death in adolescence", "Death in adulthood", "Death in childhood", "Death in infancy", "Decerebrate rigidity", "Decreased absent ankle reflexes", "Decreased achilles reflex", "Decreased activity of mitochondrial complex i", "Decreased activity of mitochondrial complex ii", "Decreased activity of mitochondrial complex iii", "Decreased activity of mitochondrial complex iv", "Decreased activity of nadph oxidase", "Decreased activity of the pyruvate dehydrogenase complex", "Decreased adenosylcobalamin", "Decreased adipose tissue", "Decreased calvarial ossification", "Decreased cd4 cd8 ratio", "Decreased cervical spine flexion due to contractures of posterior cervical muscles", "Decreased cervical spine mobility", "Decreased circulating acth level", "Decreased circulating aldosterone level", "Decreased circulating androgen concentration", "Decreased circulating antibody level", "Decreased circulating copper concentration", "Decreased circulating cortisol level", "Decreased circulating follicle stimulating hormone concentration", "Decreased circulating gaba concentration", "Decreased circulating gonadotropin concentration", "Decreased circulating iga level", "Decreased circulating igg level", "Decreased circulating igg subclass level", "Decreased circulating level of specific antibody", "Decreased circulating progesterone", "Decreased circulating total iga", "Decreased circulating total igg", "Decreased circulating total igm", "Decreased corneal reflex", "Decreased facial expression", "Decreased fertility", "Decreased fertility in females", "Decreased fertility in males", "Decreased head circumference", "Decreased lacrimation", "Decreased ldl cholesterol concentration", "Decreased libido", "Decreased light and dark adapted electroretinogram amplitude", "Decreased lymphocyte apoptosis", "Decreased lymphocyte proliferation in response to mitogen", "Decreased mean corpuscular volume", "Decreased methylcobalamin", "Decreased methylmalonyl coa mutase activity", "Decreased muscle mass", "Decreased number of large peripheral myelinated nerve fibers", "Decreased number of peripheral myelinated nerve fibers", "Decreased palmar creases", "Decreased patellar reflex", "Decreased plasma carnitine", "Decreased proportion of cd3 positive t cells", "Decreased proportion of cd4 positive helper t cells", "Decreased pulmonary function", "Decreased serum complement c3", "Decreased serum insulin like growth factor 1", "Decreased serum iron", "Decreased size of nerve terminals", "Decreased specific anti polysaccharide antibody level", "Decreased specific antibody response to polysaccharide vaccine", "Decreased specific antibody response to protein vaccine", "Decreased specific antibody response to vaccination", "Decreased specific pneumococcal antibody level", "Decreased testicular size", "Decreased urine output", "Deep palmar crease", "Deep philtrum", "Deep plantar creases", "Deep set nails", "Deep venous thrombosis", "Deeply set eye", "Defective dna repair after ultraviolet radiation damage", "Defective t cell proliferation", "Deformed rib cage", "Deformed sella turcica", "Deformed tarsal bones", "Degeneration of the lateral corticospinal tracts", "Degeneration of the striatum", "Dehydration", "Delayed ability to roll over", "Delayed ability to sit", "Delayed ability to stand", "Delayed ability to walk", "Delayed closure of the anterior fontanelle", "Delayed cns myelination", "Delayed cranial suture closure", "Delayed epiphyseal ossification", "Delayed eruption of permanent teeth", "Delayed eruption of primary teeth", "Delayed eruption of teeth", "Delayed fine motor development", "Delayed gross motor development", "Delayed menarche", "Delayed myelination", "Delayed ossification of carpal bones", "Delayed proximal femoral epiphyseal ossification", "Delayed puberty", "Delayed social development", "Delirium", "Delusions", "Dementia", "Demyelinating peripheral neuropathy", "Dental crowding", "Dental malocclusion", "Depletion of mitochondrial dna in muscle tissue", "Deposits immunoreactive to beta amyloid protein", "Depressed nasal bridge", "Depressed nasal ridge", "Depressed nasal tip", "Depression", "Dermal atrophy", "Dermal translucency", "Dermatological manifestations of systemic disorders", "Dermoid cyst", "Descending aortic dissection", "Desquamation of skin soon after birth", "Developmental cataract", "Developmental glaucoma", "Developmental regression", "Developmental stagnation", "Deviated nasal septum", "Deviation of the 2nd finger", "Deviation of the 3rd finger", "Deviation of the hallux", "Deviation of the hand or of fingers of the hand", "Deviation of the thumb", "Deviation of toes", "Diabetes insipidus", "Dialeptic seizure", "Diaphragmatic eventration", "Diaphragmatic paralysis", "Diaphragmatic weakness", "Diaphyseal sclerosis", "Diaphyseal thickening", "Diarrhea", "Diastasis recti", "Diastema", "Dicarboxylic aciduria", "Difficulty climbing stairs", "Difficulty in tongue movements", "Difficulty running", "Difficulty standing", "Difficulty walking", "Diffuse alveolar hemorrhage", "Diffuse cerebellar atrophy", "Diffuse cerebral atrophy", "Diffuse mesangial sclerosis", "Diffuse optic disc pallor", "Diffuse palmoplantar hyperkeratosis", "Diffuse white matter abnormalities", "Digenic inheritance", "Dilatation of the cerebral artery", "Dilatation of the ventricular cavity", "Dilated cardiomyopathy", "Dilated fourth ventricle", "Dilated third ventricle", "Dilation of lateral ventricles", "Dilation of virchow robin spaces", "Diminished ability to concentrate", "Diminished motivation", "Diminished movement", "Dimple chin", "Diplopia", "Disinhibition", "Displacement of the urethral meatus", "Disproportionate short limb short stature", "Disproportionate short stature", "Disproportionate short trunk short stature", "Disproportionate tall stature", "Disseminated intravascular coagulation", "Distal amyotrophy", "Distal arthrogryposis", "Distal joint laxity", "Distal lower limb amyotrophy", "Distal lower limb muscle weakness", "Distal muscle weakness", "Distal peripheral sensory neuropathy", "Distal sensory impairment", "Distal sensory impairment of all modalities", "Distal sensory loss of all modalities", "Distal upper limb amyotrophy", "Distal upper limb muscle weakness", "Disturbance of facial expression", "Dolichocephaly", "Down sloping shoulders", "Downslanted palpebral fissures", "Downturned corners of mouth", "Drowsiness", "Drusen", "Dry hair", "Dry skin", "Duodenal adenocarcinoma", "Duodenal atresia", "Duodenal stenosis", "Duplicated collecting system", "Duplication involving bones of the feet", "Duplication of hand bones", "Duplication of the distal phalanx of hand", "Duplication of thumb phalanx", "Dysarthria", "Dyscalculia", "Dyschromatopsia", "Dysdiadochokinesis", "Dysesthesia", "Dysgammaglobulinemia", "Dysgenesis of the cerebellar vermis", "Dysgerminoma", "Dysgraphia", "Dyskinesia", "Dyslexia", "Dysmenorrhea", "Dysmetria", "Dysmetric saccades", "Dysostosis multiplex", "Dyspareunia", "Dysphagia", "Dysphasia", "Dysphonia", "Dysplasia of the femoral head", "Dysplastic corpus callosum", "Dyspnea", "Dystonia", "Dystrophic fingernails", "Dystrophic toenail", "Dysuria", "Ear pain", "Early onset absence seizures", "Early onset of sexual maturation", "Easy fatigability", "Ecchymosis", "Echolalia", "Eclabion", "Eclampsia", "Ectodermal dysplasia", "Ectopia lentis", "Ectopia pupillae", "Ectopic anus", "Ectopic calcification", "Ectopic kidney", "Ectrodactyly", "Ectropion", "Ectropion of lower eyelids", "Eczema", "Eczematoid dermatitis", "Edema of the dorsum of feet", "Edema of the dorsum of hands", "Eeg with abnormally slow frequencies", "Eeg with burst suppression", "Eeg with continuous slow activity", "Eeg with focal epileptiform discharges", "Eeg with focal sharp waves", "Eeg with focal spike waves", "Eeg with focal spikes", "Eeg with generalized sharp slow waves", "Eeg with generalized slow activity", "Eeg with irregular generalized spike and wave complexes", "Eeg with multifocal slow activity", "Eeg with polyspike wave complexes", "Eeg with spike wave complexes", "Eeg with spike wave complexes 2 5 3 5 hz", "Elbow ankylosis", "Elbow flexion contracture", "Elevated alkaline phosphatase of bone origin", "Elevated calcitonin", "Elevated circulating alanine aminotransferase concentration", "Elevated circulating aspartate aminotransferase concentration", "Elevated circulating follicle stimulating hormone level", "Elevated circulating glutaric acid concentration", "Elevated circulating growth hormone concentration", "Elevated circulating long chain fatty acid concentration", "Elevated circulating parathyroid hormone level", "Elevated circulating thyroid stimulating hormone concentration", "Elevated creatine kinase after exercise", "Elevated diastolic blood pressure", "Elevated gamma glutamyltransferase level", "Elevated hemoglobin a1c", "Elevated hepatic transaminase", "Elevated lactate pyruvate ratio", "Elevated mean arterial pressure", "Elevated proportion of cd4 negative cd8 negative alpha beta regulatory t cells", "Elevated pulmonary artery pressure", "Elevated serum acid phosphatase", "Elevated systolic blood pressure", "Elevated tissue non specific alkaline phosphatase", "Elevated urinary carboxylic acid", "Elevated urinary delta aminolevulinic acid", "Elevated urinary dicarboxylic acid level", "Elevated urinary monocarboxylic acid level", "Elfin facies", "Elliptocytosis", "Elongated superior cerebellar peduncle", "Embryonal neoplasm", "Embryonal renal neoplasm", "Emg abnormality", "Emg axonal abnormality", "Emg chronic denervation signs", "Emg decremental response of compound muscle action potential to repetitive nerve stimulation", "Emg impaired neuromuscular transmission", "Emg myopathic abnormalities", "Emg neuropathic changes", "Emg slow motor conduction", "Emotional lability", "Emphysema", "Enamel hypoplasia", "Encephalocele", "Encephalopathy", "Enchondroma", "Endocardial fibroelastosis", "Endocardial fibrosis", "Endocarditis", "Enlarged cerebellum", "Enlarged cisterna magna", "Enlarged kidney", "Enlarged metaphyses", "Enlarged ovaries", "Enlarged posterior fossa", "Enlarged thorax", "Enlarged tonsils", "Enlargement of the costochondral junction", "Enlargement of the wrists", "Enterocolitis", "Enthesitis", "Entropion", "Enuresis", "Ependymoma", "Epicanthus", "Epicanthus inversus", "Epidermal acanthosis", "Epidermal hyperkeratosis", "Epidermal nevus", "Epidermoid cyst", "Epigastric pain", "Epileptic encephalopathy", "Epileptic spasm", "Epiphora", "Epiphyseal dysplasia", "Epiphyseal stippling", "Epiretinal membrane", "Episodic ataxia", "Episodic hyperhidrosis", "Episodic hypertension", "Episodic pain", "Episodic respiratory distress", "Episodic tachypnea", "Episodic vomiting", "Epispadias", "Epistaxis", "Equinovarus deformity", "Equinus calcaneus", "Erectile dysfunction", "Erlenmeyer flask deformity of the femurs", "Eruption failure", "Erysipelas", "Erythema", "Erythema nodosum", "Erythematous papule", "Erythematous plaque", "Erythrocyte inclusion bodies", "Erythroderma", "Erythroid hyperplasia", "Erythroid hypoplasia", "Esodeviation", "Esophageal atresia", "Esophageal carcinoma", "Esophageal neoplasm", "Esophageal stenosis", "Esophageal stricture", "Esophageal varix", "Esophagitis", "Ethylmalonic aciduria", "Eunuchoid habitus", "Euryblepharon", "Eversion of lateral third of lower eyelids", "Everted upper lip vermilion", "Exaggerated cupid s bow", "Exaggerated startle response", "Excessive daytime somnolence", "Excessive salivation", "Excessive wrinkled skin", "Excessive wrinkling of palmar skin", "Exercise induced muscle cramps", "Exercise induced muscle fatigue", "Exercise induced muscle stiffness", "Exercise induced myalgia", "Exercise induced myoglobinuria", "Exercise induced rhabdomyolysis", "Exercise intolerance", "Exertional dyspnea", "Exodeviation", "Exostoses", "Expressive aphasia", "Expressive language delay", "External ear malformation", "External genital hypoplasia", "External ophthalmoplegia", "Extra axial cerebrospinal fluid accumulation", "Extrahepatic cholestasis", "Extramedullary hematopoiesis", "Extrapyramidal dyskinesia", "Extrapyramidal muscular rigidity", "Eyelid coloboma", "Eyelid myoclonus", "Facial asymmetry", "Facial capillary hemangioma", "Facial cleft", "Facial diplegia", "Facial edema", "Facial erythema", "Facial grimacing", "Facial hemangioma", "Facial hyperostosis", "Facial hypertrichosis", "Facial hypotonia", "Facial myokymia", "Facial shape deformation", "Facial telangiectasia", "Failure of eruption of permanent teeth", "Failure to thrive", "Failure to thrive in infancy", "Fair hair", "Falls", "Fasciculations", "Fasting hyperinsulinemia", "Fasting hypoglycemia", "Fat malabsorption", "Fatigable weakness of bulbar muscles", "Fatigable weakness of distal limb muscles", "Fatigable weakness of respiratory muscles", "Fatigable weakness of skeletal muscles", "Fatigable weakness of swallowing muscles", "Fatiguable weakness of proximal limb muscles", "Fatigue", "Fatty replacement of skeletal muscle", "Feeding difficulties", "Feeding difficulties in infancy", "Female external genitalia in individual with 46 xy karyotype", "Female hypogonadism", "Female infertility", "Female pseudohermaphroditism", "Female reproductive system neoplasm", "Female sexual dysfunction", "Femoral bowing", "Femoral hernia", "Fetal akinesia sequence", "Fetal distress", "Fetal onset", "Fetal polyuria", "Fetal ultrasound soft marker", "Fever", "Fibroadenoma of the breast", "Fibrosarcoma", "Fibrous tissue neoplasm", "Fibular aplasia", "Fibular hypoplasia", "Fine hair", "Finger agnosia", "Finger clinodactyly", "Finger swelling", "Finger syndactyly", "Fingernail dysplasia", "Fingerprint intracellular accumulation of autofluorescent lipopigment storage material", "First degree atrioventricular block", "First dorsal interossei muscle weakness", "Flank pain", "Flared iliac wing", "Flared metaphysis", "Flared nostrils", "Flaring of rib cage", "Flat acetabular roof", "Flat cornea", "Flat face", "Flat forehead", "Flat nasal alae", "Flat occiput", "Flattened epiphysis", "Flattened femoral epiphysis", "Flattened femoral head", "Flexion contracture of digit", "Flexion contracture of thumb", "Fluctuations in consciousness", "Flushing", "Foam cells", "Focal aware seizure", "Focal cortical dysplasia", "Focal cortical dysplasia type ii", "Focal dystonia", "Focal emotional seizure", "Focal impaired awareness seizure", "Focal motor seizure", "Focal myoclonic seizure", "Focal non motor seizure", "Focal onset seizure", "Focal segmental glomerulosclerosis", "Focal t2 hyperintense basal ganglia lesion", "Focal t2 hyperintense brainstem lesion", "Focal tonic seizure", "Focal white matter lesions", "Follicular hyperkeratosis", "Follicular hyperplasia", "Follicular thyroid carcinoma", "Food allergy", "Food intolerance", "Foot acroosteolysis", "Foot dorsiflexor weakness", "Foot oligodactyly", "Fractures of the long bones", "Fragile nails", "Fragile skin", "Fragmented epiphyses", "Freckling", "Frequent falls", "Frontal balding", "Frontal cortical atrophy", "Frontal hirsutism", "Frontal lobe dementia", "Frontotemporal cerebral atrophy", "Frontotemporal dementia", "Full cheeks", "Fulminant hepatic failure", "Functional abnormality of male internal genitalia", "Functional abnormality of the gastrointestinal tract", "Functional abnormality of the inner ear", "Functional abnormality of the middle ear", "Functional intestinal obstruction", "Functional motor deficit", "Furrowed tongue", "Fused cervical vertebrae", "Fusion of the cerebellar hemispheres", "Gait ataxia", "Gait disturbance", "Gait imbalance", "Galactorrhea", "Gangrene", "Gastric ulcer", "Gastritis", "Gastroesophageal reflux", "Gastrointestinal atresia", "Gastrointestinal carcinoma", "Gastrointestinal hemorrhage", "Gastrointestinal infarctions", "Gastrointestinal inflammation", "Gastrointestinal obstruction", "Gastrointestinal stroma tumor", "Gastroparesis", "Gastrostomy tube feeding in infancy", "Gaze evoked nystagmus", "Generalized abnormality of skin", "Generalized aminoaciduria", "Generalized amyotrophy", "Generalized clonic seizure", "Generalized dystonia", "Generalized edema", "Generalized hirsutism", "Generalized hyperkeratosis", "Generalized hyperpigmentation", "Generalized hyperreflexia", "Generalized hypertrichosis", "Generalized hypopigmentation", "Generalized hypopigmentation of hair", "Generalized hypotonia", "Generalized joint laxity", "Generalized limb muscle atrophy", "Generalized lipodystrophy", "Generalized lymphadenopathy", "Generalized muscle weakness", "Generalized myoclonic atonic seizure", "Generalized myoclonic seizure", "Generalized neonatal hypotonia", "Generalized onset motor seizure", "Generalized onset seizure", "Generalized osteoporosis", "Generalized osteosclerosis", "Generalized tonic seizure", "Genetic anticipation", "Genital neoplasm", "Genu valgum", "Genu varum", "Geographic atrophy", "Germ cell neoplasia", "Germinoma", "Giant platelets", "Giant somatosensory evoked potentials", "Gingival bleeding", "Gingival fibromatosis", "Gingival overgrowth", "Gingival recession", "Gingivitis", "Glaucoma", "Glioblastoma multiforme", "Glioma", "Gliosis", "Global brain atrophy", "Glomerular deposits", "Glomerular sclerosis", "Glomerulonephritis", "Glomerulopathy", "Glomus jugular tumor", "Glossitis", "Glossoptosis", "Glucose intolerance", "Glutaric aciduria", "Glycosuria", "Goiter", "Gonadal dysgenesis", "Gonadal neoplasm", "Gonadoblastoma", "Gonosomal inheritance", "Gout", "Gowers sign", "Grammar specific speech disorder", "Granulocytopenia", "Granulomatosis", "Gray matter heterotopia", "Gynecomastia", "Hallucinations", "Hallux valgus", "Hamartoma", "Hamartoma of the eye", "Hamartoma of tongue", "Hamartomatous polyposis", "Hammertoe", "Hamstring contractures", "Hand apraxia", "Hand clenching", "Hand muscle weakness", "Hand oligodactyly", "Hand polydactyly", "Hand tremor", "Handgrip myotonia", "Happy demeanor", "Hashimoto thyroiditis", "Head banging", "Head titubation", "Head tremor", "Headache", "Heart block", "Heat intolerance", "Heinz bodies", "Hemangioblastoma", "Hemangiomatosis", "Hematochezia", "Hematological neoplasm", "Hemianopia", "Hemiatrophy", "Hemifacial spasm", "Hemihypertrophy", "Hemimegalencephaly", "Hemiparesis", "Hemiplegia hemiparesis", "Hemivertebrae", "Hemoglobinuria", "Hemolytic anemia", "Hemoptysis", "Hemorrhage of the eye", "Heparan sulfate excretion in urine", "Hepatic cysts", "Hepatic encephalopathy", "Hepatic failure", "Hepatic fibrosis", "Hepatic necrosis", "Hepatitis", "Hepatoblastoma", "Hepatocellular adenoma", "Hepatocellular carcinoma", "Hepatomegaly", "Hepatosplenomegaly", "Hereditary nonpolyposis colorectal carcinoma", "Hernia", "Herpes simplex encephalitis", "Heterochromia iridis", "Heterogeneous", "Heteronymous hemianopia", "Heterotaxy", "Heterotropia", "Hiatus hernia", "High anterior hairline", "High forehead", "High frequency hearing impairment", "High frequency sensorineural hearing impairment", "High hypermetropia", "High myopia", "High narrow palate", "High palate", "High pitched voice", "Highly arched eyebrow", "Hip contracture", "Hip dislocation", "Hip dysplasia", "Hip flexor weakness", "Hip osteoarthritis", "Hip pain", "Hip subluxation", "Hirsutism", "Hoarse cry", "Hoarse voice", "Hodgkin lymphoma", "Holoprosencephaly", "Homocystinuria", "Honeycomb lung", "Horizontal eyebrow", "Horizontal nystagmus", "Horizontal pendular nystagmus", "Horseshoe kidney", "Humeroradial synostosis", "Hydranencephaly", "Hydrocele testis", "Hydrocephalus", "Hydrops fetalis", "Hydroureter", "Hydroxyprolinuria", "Hyperactive deep tendon reflexes", "Hyperactive patellar reflex", "Hyperactivity", "Hyperacusis", "Hyperaldosteronism", "Hyperammonemia", "Hyperautofluorescent retinal lesion", "Hypercalcemia", "Hyperchloremic acidosis", "Hypercholesterolemia", "Hypercoagulability", "Hyperconvex fingernails", "Hyperconvex nail", "Hyperesthesia", "Hyperextensibility at wrists", "Hyperextensibility of the finger joints", "Hyperextensible skin", "Hypergalactosemia", "Hyperglycemia", "Hypergonadotropic hypogonadism", "Hypergranulosis", "Hyperhidrosis", "Hyperhomocystinemia", "Hyperinsulinemic hypoglycemia", "Hyperintensity of cerebral white matter on mri", "Hyperkalemia", "Hyperkeratosis", "Hyperkeratotic papule", "Hyperketonemia", "Hyperkinetic movements", "Hyperlipidemia", "Hyperlipoproteinemia", "Hyperlordosis", "Hypermagnesemia", "Hypermethioninemia", "Hypermetric saccades", "Hypermetropia", "Hypernatriuria", "Hyperorality", "Hyperostosis", "Hyperoxaluria", "Hyperparathyroidism", "Hyperphenylalaninemia", "Hyperphosphatemia", "Hyperphosphaturia", "Hyperpigmentation in sun exposed areas", "Hyperpigmentation of the fundus", "Hyperpigmentation of the skin", "Hyperpituitarism", "Hyperplasia of the maxilla", "Hyperreflexia", "Hyperreflexia in upper limbs", "Hypersomnia", "Hypersplenism", "Hypertelorism", "Hypertension associated with pheochromocytoma", "Hypertensive crisis", "Hyperthyroidism", "Hypertonia", "Hypertrichosis", "Hypertriglyceridemia", "Hypertrophic cardiomyopathy", "Hypertrophic nerve changes", "Hyperuricemia", "Hyperuricosuria", "Hyperventilation", "Hypoamylasemia", "Hypocalcemia", "Hypocalcemic seizures", "Hypocalcemic tetany", "Hypocalciuria", "Hypochloremia", "Hypocholesterolemia", "Hypochromia", "Hypochromic anemia", "Hypochromic microcytic anemia", "Hypodontia", "Hypoglycemic coma", "Hypoglycemic seizures", "Hypoglycorrhachia", "Hypogonadism", "Hypogonadotropic hypogonadism", "Hypohidrosis", "Hypoinsulinemia", "Hypointensity of cerebral white matter on mri", "Hypokalemia", "Hypokalemic alkalosis", "Hypokalemic metabolic alkalosis", "Hypoketotic hypoglycemia", "Hypokinesia", "Hypolipidemia", "Hypolipoproteinemia", "Hypomelanotic macule", "Hypomethioninemia", "Hypometric saccades", "Hypomimic face", "Hypoparathyroidism", "Hypophosphatemia", "Hypophosphatemic rickets", "Hypopigmentation of the fundus", "Hypopigmentation of the skin", "Hypopigmented macule", "Hypopigmented skin patches", "Hypopituitarism", "Hypoplasia of olfactory tract", "Hypoplasia of penis", "Hypoplasia of teeth", "Hypoplasia of the brainstem", "Hypoplasia of the corpus callosum", "Hypoplasia of the ear cartilage", "Hypoplasia of the epiglottis", "Hypoplasia of the femoral head", "Hypoplasia of the fovea", "Hypoplasia of the frontal lobes", "Hypoplasia of the iris", "Hypoplasia of the musculature", "Hypoplasia of the odontoid process", "Hypoplasia of the olfactory bulb", "Hypoplasia of the pons", "Hypoplasia of the radius", "Hypoplasia of the uterus", "Hypoplasia of the vagina", "Hypoplasia of the ventral pons", "Hypoplastic anemia", "Hypoplastic aortic arch", "Hypoplastic cervical vertebrae", "Hypoplastic dermoepidermal hemidesmosomes", "Hypoplastic facial bones", "Hypoplastic female external genitalia", "Hypoplastic fifth fingernail", "Hypoplastic fifth toenail", "Hypoplastic fingernail", "Hypoplastic frontal sinuses", "Hypoplastic heart", "Hypoplastic helices", "Hypoplastic hippocampus", "Hypoplastic ilia", "Hypoplastic iris stroma", "Hypoplastic labia majora", "Hypoplastic labia minora", "Hypoplastic nipples", "Hypoplastic pelvis", "Hypoplastic pubic rami", "Hypoplastic toenails", "Hypoplastic vertebral bodies", "Hypoproteinemia", "Hyporeflexia", "Hyporeflexia of lower limbs", "Hyporeflexia of upper limbs", "Hyposmia", "Hypotelorism", "Hypotension", "Hypothalamic hamartoma", "Hypothalamic hypothyroidism", "Hypothermia", "Hypotriglyceridemia", "Hypouricemia", "Hypoventilation", "Hypovolemic shock", "Hypsarrhythmia", "Ichthyosis", "Ileus", "Immotile sperm", "Immune dysregulation", "Immunodeficiency", "Immunologic hypersensitivity", "Impacted tooth", "Impaired adp induced platelet aggregation", "Impaired antigen specific response", "Impaired collagen induced platelet aggregation", "Impaired distal proprioception", "Impaired distal tactile sensation", "Impaired distal vibration sensation", "Impaired epinephrine induced platelet aggregation", "Impaired glucose tolerance", "Impaired horizontal smooth pursuit", "Impaired mastication", "Impaired neutrophil bactericidal activity", "Impaired oropharyngeal swallow response", "Impaired pain sensation", "Impaired proprioception", "Impaired smooth pursuit", "Impaired social interactions", "Impaired t cell function", "Impaired tactile sensation", "Impaired tandem gait", "Impaired temperature sensation", "Impaired use of nonverbal behaviors", "Impaired vibration sensation at ankles", "Impaired vibration sensation in the lower limbs", "Impaired vibratory sensation", "Impaired visuospatial constructive cognition", "Impairment in personality functioning", "Impairment of activities of daily living", "Impotence", "Inability to walk", "Inappropriate antidiuretic hormone secretion", "Inappropriate behavior", "Inappropriate crying", "Inappropriate laughter", "Incisor macrodontia", "Incomitant strabismus", "Incomplete partition of the cochlea type ii", "Incomplete penetrance", "Incomprehensible speech", "Incoordination", "Increased adipose tissue", "Increased arm span", "Increased aspartate family amino acid level in urine", "Increased b cell count", "Increased blood pressure", "Increased blood urea nitrogen", "Increased body mass index", "Increased body weight", "Increased bone mineral density", "Increased c peptide level", "Increased cerebral lipofuscin", "Increased circulating acth level", "Increased circulating androgen concentration", "Increased circulating antibody level", "Increased circulating cortisol level", "Increased circulating gonadotropin level", "Increased circulating iga level", "Increased circulating igg level", "Increased circulating igm level", "Increased circulating lactate dehydrogenase concentration", "Increased circulating prolactin concentration", "Increased circulating renin level", "Increased connective tissue", "Increased csf lactate", "Increased density of long bones", "Increased endomysial connective tissue", "Increased fecal porphyrin", "Increased head circumference", "Increased hepatic glycogen content", "Increased hepatocellular lipid droplets", "Increased intracranial pressure", "Increased intramyocellular lipid droplets", "Increased laxity of ankles", "Increased ldl cholesterol concentration", "Increased level of hippuric acid in urine", "Increased level of l fucose in urine", "Increased mean corpuscular hemoglobin concentration", "Increased mean corpuscular volume", "Increased megakaryocyte count", "Increased muscle fatiguability", "Increased muscle glycogen content", "Increased muscle lipid content", "Increased nuchal translucency", "Increased overbite", "Increased proteinogenic amino acid level in urine", "Increased sensitivity to ionizing radiation", "Increased serine family amino acid in urine", "Increased serum iron", "Increased serum lactate", "Increased serum pyruvate", "Increased serum serotonin", "Increased serum testosterone level", "Increased skull ossification", "Increased sulfur amino acid level in urine", "Increased susceptibility to fractures", "Increased theta frequency activity in eeg", "Increased total bilirubin", "Increased urinary cortisol level", "Increased urinary non proteinogenic amino acid level", "Increased urine alpha ketoglutarate concentration", "Increased urine proteinogenic amino acid derivative level", "Increased vertebral height", "Ineffective esophageal peristalsis", "Infantile axial hypotonia", "Infantile encephalopathy", "Infantile muscular hypotonia", "Infantile onset", "Infantile spasms", "Infection related seizure", "Infectious encephalitis", "Inferior lens subluxation", "Inferior vermis hypoplasia", "Infertility", "Inflammation of the large intestine", "Inflammatory abnormality of the eye", "Inflexible adherence to routines or rituals", "Inguinal freckling", "Inguinal hernia", "Insidious onset", "Insomnia", "Inspiratory stridor", "Insulin resistance", "Insulin resistant diabetes mellitus", "Intellectual disability borderline", "Intellectual disability mild", "Intellectual disability moderate", "Intellectual disability profound", "Intellectual disability progressive", "Intellectual disability severe", "Intercostal muscle weakness", "Interictal eeg abnormality", "Intermittent diarrhea", "Intermittent episodes of respiratory insufficiency due to muscle weakness", "Internally nucleated skeletal muscle fibers", "Interrupted aortic arch", "Interstitial cardiac fibrosis", "Interstitial pneumonitis", "Intestinal atresia", "Intestinal bleeding", "Intestinal fistula", "Intestinal hypoplasia", "Intestinal malrotation", "Intestinal polyp", "Intestinal pseudo obstruction", "Intraalveolar phospholipid accumulation", "Intracellular accumulation of autofluorescent lipopigment storage material", "Intracranial hemorrhage", "Intracranial meningioma", "Intractable diarrhea", "Intrauterine growth retardation", "Intrinsic hand muscle atrophy", "Intussusception", "Inverted nipples", "Involuntary movements", "Iridocyclitis", "Iris atrophy", "Iris coloboma", "Iris hypopigmentation", "Iron accumulation in brain", "Iron accumulation in globus pallidus", "Iron deficiency anemia", "Irregular capital femoral epiphysis", "Irregular epiphyses", "Irregular femoral epiphysis", "Irregular hyperpigmentation", "Irregular menstruation", "Irregular vertebral endplates", "Irritability", "Ischemic stroke", "J shaped sella turcica", "Jaundice", "Jerky head movements", "Jerky ocular pursuit movements", "Joint contracture of the hand", "Joint contractures involving the joints of the feet", "Joint dislocation", "Joint hemorrhage", "Joint hyperflexibility", "Joint hypermobility", "Joint laxity", "Joint stiffness", "Joint subluxation", "Joint swelling", "Juvenile aseptic necrosis", "Juvenile cataract", "Juvenile myelomonocytic leukemia", "Juvenile onset", "Juvenile rheumatoid arthritis", "Keloids", "Keratitis", "Keratoconjunctivitis", "Keratosis pilaris", "Ketoacidosis", "Ketonuria", "Ketosis", "Ketotic hypoglycemia", "Kinetic tremor", "Knee clonus", "Knee dislocation", "Knee flexion contracture", "Kyphoscoliosis", "Kyphosis", "Labial hypertrophy", "Lack of insight", "Lack of peer relationships", "Lack of skin elasticity", "Lack of t cell function", "Lacrimal duct atresia", "Lacrimal duct stenosis", "Lacrimation abnormality", "Lactic acidosis", "Lacticaciduria", "Lactose intolerance", "Lagopthalmos", "Lambdoidal craniosynostosis", "Language impairment", "Large basal ganglia", "Large beaked nose", "Large earlobe", "Large face", "Large fleshy ears", "Large for gestational age", "Large foramen magnum", "Large forehead", "Large hands", "Large iliac wing", "Large intestinal polyposis", "Large placenta", "Large sella turcica", "Laryngeal cleft", "Laryngeal dystonia", "Laryngeal hypoplasia", "Laryngeal stenosis", "Laryngeal stridor", "Laryngomalacia", "Laryngotracheomalacia", "Late onset", "Lateral clavicle hook", "Left atrial enlargement", "Left to right shunt", "Left ventricular hypertrophy", "Left ventricular noncompaction cardiomyopathy", "Left ventricular outflow tract obstruction", "Left ventricular systolic dysfunction", "Leg muscle stiffness", "Leiomyosarcoma", "Lens subluxation", "Lethal skeletal dysplasia", "Lethargy", "Leukemia", "Leukocytosis", "Leukodystrophy", "Leukoencephalopathy", "Leukonychia", "Leukopenia", "Lewy bodies", "Leydig cell neoplasia", "Lichenification", "Limb ataxia", "Limb dystonia", "Limb fasciculations", "Limb girdle muscle atrophy", "Limb girdle muscle weakness", "Limb girdle muscular dystrophy", "Limb hypertonia", "Limb joint contracture", "Limb muscle weakness", "Limb myoclonus", "Limb pain", "Limb tremor", "Limb undergrowth", "Limitation of joint mobility", "Limitation of knee mobility", "Limitation of movement at ankles", "Limitation of neck motion", "Limited elbow extension", "Limited elbow movement", "Limited extraocular movements", "Limited hip extension", "Limited hip movement", "Limited wrist movement", "Lipid accumulation in hepatocytes", "Lipoatrophy", "Lipodystrophy", "Lipoma", "Lissencephaly", "Liver abscess", "Lobulated tongue", "Localized hirsutism", "Localized osteoporosis", "Localized skin lesion", "Long clavicles", "Long ear", "Long eyelashes", "Long fingers", "Long foot", "Long hallux", "Long neck", "Long nose", "Long palm", "Long palpebral fissure", "Long penis", "Long philtrum", "Long thorax", "Long toe", "Long tract signs", "Long upper lip", "Lop ear", "Loss of ability to walk", "Loss of consciousness", "Loss of eyelashes", "Loss of purkinje cells in the cerebellar vermis", "Loss of speech", "Loss of subcutaneous adipose tissue in limbs", "Loss of voice", "Low alkaline phosphatase", "Low anterior hairline", "Low apgar score", "Low back pain", "Low frustration tolerance", "Low grade fever", "Low hanging columella", "Low levels of vitamin d", "Low posterior hairline", "Low self esteem", "Low set nipples", "Low set posteriorly rotated ears", "Lower extremity joint dislocation", "Lower eyelid coloboma", "Lower limb amyotrophy", "Lower limb asymmetry", "Lower limb hyperreflexia", "Lower limb hypertonia", "Lower limb metaphyseal irregularity", "Lower limb muscle weakness", "Lower limb pain", "Lower limb spasticity", "Lower limb undergrowth", "Lumbar hyperlordosis", "Lumbar kyphosis", "Lumbar scoliosis", "Lung adenocarcinoma", "Lymphangiectasis", "Lymphangioma", "Lymphedema", "Lymphocytosis", "Lymphoma", "Lymphopenia", "Lymphoproliferative disorder", "Macrocephaly at birth", "Macrocytic anemia", "Macrodactyly", "Macrodontia", "Macrodontia of permanent maxillary central incisor", "Macroglossia", "Macrogyria", "Macroorchidism", "Macroscopic hematuria", "Macrotia", "Macrovesicular hepatic steatosis", "Macular atrophy", "Macular coloboma", "Macular degeneration", "Macular hyperpigmentation", "Macular purpura", "Macular thickening", "Macule", "Malabsorption", "Malar prominence", "Male hypogonadism", "Male infertility", "Male pseudohermaphroditism", "Male reproductive system neoplasm", "Male sexual dysfunction", "Malignant genitourinary tract tumor", "Malignant hyperthermia", "Malignant neoplasm of the central nervous system", "Malnutrition", "Malrotation of small bowel", "Mandibular aplasia", "Mandibular prognathia", "Mania", "Mask like facies", "Mastoiditis", "Maternal diabetes", "Maternal hypertension", "Maturity onset diabetes of the young", "Meconium stained amniotic fluid", "Medial flaring of the eyebrow", "Median cleft lip", "Median cleft palate", "Mediastinal lymphadenopathy", "Medullary nephrocalcinosis", "Medulloblastoma", "Megalencephaly", "Megaloblastic anemia", "Megalocornea", "Melanocytic nevus", "Melanoma", "Melena", "Membranoproliferative glomerulonephritis", "Memory impairment", "Meningioma", "Meningitis", "Meningocele", "Menorrhagia", "Mental deterioration", "Mesoaxial hand polydactyly", "Mesoaxial polydactyly", "Mesomelia", "Metabolic acidosis", "Metabolic alkalosis", "Metacarpophalangeal joint contracture", "Metamorphopsia", "Metaphyseal chondrodysplasia", "Metaphyseal cupping", "Metaphyseal dysplasia", "Metaphyseal irregularity", "Metaphyseal sclerosis", "Metaphyseal striations", "Metaphyseal widening", "Metatarsal synostosis", "Metatarsus adductus", "Metatarsus valgus", "Methemoglobinemia", "Methylmalonic acidemia", "Methylmalonic aciduria", "Metopic synostosis", "Metrorrhagia", "Microcornea", "Microcytic anemia", "Microdontia", "Microglossia", "Micrographia", "Micromelia", "Micronodular cirrhosis", "Micropenis", "Microphallus", "Microretrognathia", "Microscopic hematuria", "Microtia third degree", "Microvesicular hepatic steatosis", "Middle age onset", "Midface retrusion", "Midline defect of the nose", "Migraine", "Mild global developmental delay", "Mild hearing impairment", "Mild microcephaly", "Mild postnatal growth retardation", "Mild short stature", "Mildly elevated creatine kinase", "Milia", "Minicore myopathy", "Minimal change glomerulonephritis", "Misalignment of incisors", "Missing ribs", "Mitochondrial inheritance", "Mitochondrial myopathy", "Mitochondrial respiratory chain defects", "Mitral stenosis", "Mitral valve calcification", "Mitral valve prolapse", "Mitten deformity", "Mixed demyelinating and axonal polyneuropathy", "Mixed hearing impairment", "Mixed hypo and hyperpigmentation of the skin", "Moderate albuminuria", "Moderate global developmental delay", "Moderate sensorineural hearing impairment", "Moderately reduced visual acuity", "Molar tooth sign on mri", "Molluscoid pseudotumors", "Monochromacy", "Monocytosis", "Monotonic speech", "Mood swings", "Morning glory anomaly", "Morning myoclonic jerks", "Morphological abnormality of the corticospinal tract", "Morphological abnormality of the middle ear", "Morphological abnormality of the pyramidal tract", "Mortality aging", "Motor axonal neuropathy", "Motor delay", "Motor deterioration", "Motor neuron atrophy", "Motor polyneuropathy", "Motor regression", "Motor seizure", "Mottled pigmentation", "Movement abnormality of the tongue", "Moyamoya phenomenon", "Mucosal telangiectasiae", "Multicystic kidney dysplasia", "Multifactorial inheritance", "Multifocal cerebral white matter abnormalities", "Multifocal epileptiform discharges", "Multifocal seizures", "Multiple cafe au lait spots", "Multiple enchondromatosis", "Multiple gastric polyps", "Multiple impacted teeth", "Multiple joint contractures", "Multiple joint dislocation", "Multiple lentigines", "Multiple lipomas", "Multiple mitochondrial dna deletions", "Multiple myeloma", "Multiple prenatal fractures", "Multiple renal cysts", "Multiple rib fractures", "Multiple rows of eyelashes", "Multiple suture craniosynostosis", "Muscle abnormality related to mitochondrial dysfunction", "Muscle fiber atrophy", "Muscle fiber inclusion bodies", "Muscle fiber necrosis", "Muscle fiber splitting", "Muscle fiber tubular inclusions", "Muscle fibrillation", "Muscle flaccidity", "Muscle hypertrophy of the lower extremities", "Muscle spasm", "Muscle stiffness", "Muscle weakness", "Muscular dystrophy", "Muscular hypotonia of the trunk", "Muscular ventricular septal defect", "Mutism", "Myalgia", "Mydriasis", "Myelodysplasia", "Myelofibrosis", "Myeloid leukemia", "Myelomeningocele", "Myelopathy", "Myeloproliferative disorder", "Myocardial fibrosis", "Myoclonic absence seizure", "Myoclonic seizure", "Myoclonic spasms", "Myoclonus", "Myofibrillar myopathy", "Myoglobinuria", "Myokymia", "Myopathic facies", "Myopathy", "Myopia", "Myositis", "Myotonia", "Naevus flammeus of the eyelid", "Nail dysplasia", "Nail dystrophy", "Nail pits", "Narrow face", "Narrow foot", "Narrow foramen obturatorium", "Narrow forehead", "Narrow iliac wing", "Narrow internal auditory canal", "Narrow jaw", "Narrow mouth", "Narrow nasal bridge", "Narrow nasal ridge", "Narrow nose", "Narrow palate", "Narrow palpebral fissure", "Narrow pelvis bone", "Narrow vertebral interpedicular distance", "Nasal congestion", "Nasal regurgitation", "Nasal speech", "Nasogastric tube feeding", "Nasogastric tube feeding in infancy", "Nasolacrimal duct obstruction", "Natal tooth", "Nausea", "Nausea and vomiting", "Neck flexor weakness", "Neck muscle weakness", "Negativism", "Nemaline bodies", "Neonatal alloimmune thrombocytopenia", "Neonatal asphyxia", "Neonatal breathing dysregulation", "Neonatal death", "Neonatal hyperbilirubinemia", "Neonatal hypoglycemia", "Neonatal hypotonia", "Neonatal insulin dependent diabetes mellitus", "Neonatal onset", "Neonatal respiratory distress", "Neoplasm", "Neoplasm by histology", "Neoplasm of fatty tissue", "Neoplasm of head and neck", "Neoplasm of striated muscle", "Neoplasm of the adrenal cortex", "Neoplasm of the adrenal gland", "Neoplasm of the breast", "Neoplasm of the colon", "Neoplasm of the ear", "Neoplasm of the endocrine system", "Neoplasm of the eye", "Neoplasm of the gallbladder", "Neoplasm of the gastrointestinal tract", "Neoplasm of the genitourinary tract", "Neoplasm of the heart", "Neoplasm of the inner ear", "Neoplasm of the large intestine", "Neoplasm of the larynx", "Neoplasm of the liver", "Neoplasm of the male external genitalia", "Neoplasm of the middle ear", "Neoplasm of the nervous system", "Neoplasm of the oral cavity", "Neoplasm of the pancreas", "Neoplasm of the parathyroid gland", "Neoplasm of the peripheral nervous system", "Neoplasm of the pituitary gland", "Neoplasm of the rectum", "Neoplasm of the respiratory system", "Neoplasm of the skeletal system", "Neoplasm of the skin", "Neoplasm of the small intestine", "Neoplasm of the stomach", "Neoplasm of the thyroid gland", "Neoplasm of the tongue", "Neoplasm of the tracheobronchial system", "Nephritis", "Nephrocalcinosis", "Nephrogenic diabetes insipidus", "Nephrolithiasis", "Nephronophthisis", "Nephropathy", "Nephrotic syndrome", "Neuralgia", "Neurodegeneration", "Neuroendocrine neoplasm", "Neurofibrillary tangles", "Neurofibromas", "Neurogenic bladder", "Neuroinflammation", "Neuromuscular dysphagia", "Neuronal loss in basal ganglia", "Neuronal loss in central nervous system", "Neuronal loss in the cerebral cortex", "Neuropathic arthropathy", "Neutropenia in presence of anti neutropil antibodies", "Nevus", "Night sweats", "No social interaction", "Nocturia", "Nocturnal hypoventilation", "Nocturnal seizures", "Nodular goiter", "Non hodgkin lymphoma", "Non medullary thyroid carcinoma", "Non midline cleft lip", "Non midline cleft palate", "Non motor seizure", "Noncompaction cardiomyopathy", "Nonimmune hydrops fetalis", "Nonketotic hypoglycemia", "Nonprogressive", "Nonprogressive cerebellar ataxia", "Nonprogressive encephalopathy", "Nonspherocytic hemolytic anemia", "Normochromic anemia", "Normocytic anemia", "Nuclear cataract", "Numerous nevi", "Numerous pigmented freckles", "Nyctalopia", "Nystagmus induced head nodding", "Obsessive compulsive behavior", "Obsessive compulsive trait", "Obstructive sleep apnea", "Occipital cortical atrophy", "Occipital encephalocele", "Occipital meningocele", "Ocular albinism", "Ocular anterior segment dysgenesis", "Ocular pain", "Oculogyric crisis", "Oculomotor apraxia", "Oculomotor nerve palsy", "Odontogenic neoplasm", "Oligoarthritis", "Oligodactyly", "Oligodontia", "Oligohydramnios", "Oligomenorrhea", "Oligosacchariduria", "Oligospermia", "Oliguria", "Olivopontocerebellar atrophy", "Olivopontocerebellar hypoplasia", "Omphalocele", "Onion bulb formation", "Onset", "Onychogryposis", "Onychogryposis of toenails", "Onycholysis", "Onychomycosis", "Open angle glaucoma", "Open bite", "Open mouth", "Open operculum", "Ophthalmoparesis", "Opisthotonus", "Opportunistic infection", "Opsoclonus", "Optic atrophy", "Optic disc coloboma", "Optic disc hypoplasia", "Optic disc pallor", "Optic nerve dysplasia", "Optic nerve hypoplasia", "Optic neuropathy", "Oral aversion", "Oral cavity bleeding", "Oral cleft", "Oral leukoplakia", "Oral mucosal blisters", "Oral pharyngeal dysphagia", "Oral ulcer", "Orchitis", "Organic aciduria", "Orofacial dyskinesia", "Oromandibular dystonia", "Oromotor apraxia", "Oroticaciduria", "Orthopnea", "Orthostatic hypotension", "Orthostatic hypotension due to autonomic dysfunction", "Osteoarthritis", "Osteochondroma", "Osteochondrosis", "Osteolysis", "Osteolysis involving bones of the feet", "Osteolysis involving bones of the upper limbs", "Osteolytic defects of the distal phalanges of the hand", "Osteomalacia", "Osteomyelitis", "Osteopenia", "Osteopetrosis", "Osteoporosis", "Osteosarcoma", "Otitis media", "Otosclerosis", "Oval face", "Ovarian carcinoma", "Ovarian cyst", "Ovarian gonadoblastoma", "Ovarian neoplasm", "Ovarian papillary adenocarcinoma", "Overfolding of the superior helices", "Overfriendliness", "Overgrowth", "Overhanging nasal tip", "Overlapping fingers", "Overlapping toe", "Overriding aorta", "Overtubulated long bones", "Overweight", "Ovoid vertebral bodies", "Ovotestis", "Pace of progression", "Pain", "Pain in head and neck region", "Pain insensitivity", "Painless fractures due to injury", "Pallor", "Palmar hyperhidrosis", "Palmar pits", "Palmar telangiectasia", "Palmoplantar blistering", "Palmoplantar cutis laxa", "Palmoplantar hyperhidrosis", "Palpebral edema", "Palpitations", "Pancreatic adenocarcinoma", "Pancreatic cysts", "Pancreatic fibrosis", "Pancreatic hypoplasia", "Pancreatic islet cell hyperplasia", "Pancreatitis", "Pancytopenia", "Panhypogammaglobulinemia", "Panhypopituitarism", "Panniculitis", "Papillary renal cell carcinoma", "Papillary thyroid carcinoma", "Papilledema", "Papilloma", "Papule", "Paracentral scotoma", "Paraganglioma", "Parakeratosis", "Paralysis", "Paranoia", "Paraparesis", "Paraplegia", "Paraplegia paraparesis", "Parasomnia", "Parathyroid adenoma", "Parathyroid carcinoma", "Paresthesia", "Parietal bossing", "Parietal cortical atrophy", "Parietal foramina", "Parkinsonism", "Parkinsonism with favorable response to dopaminergic medication", "Paronychia", "Paroxysmal bursts of laughter", "Paroxysmal dyskinesia", "Paroxysmal dystonia", "Paroxysmal involuntary eye movements", "Paroxysmal ventricular tachycardia", "Partial agenesis of the corpus callosum", "Partial anomalous pulmonary venous return", "Partial duplication of the phalanx of hand", "Patchy alopecia", "Patchy changes of bone mineral density", "Patchy hypopigmentation of hair", "Patchy palmoplantar hyperkeratosis", "Patellar aplasia", "Patellar dislocation", "Patellar hypoplasia", "Patellar subluxation", "Patent ductus arteriosus", "Patent foramen ovale", "Pathologic fracture", "Pectus carinatum", "Pectus excavatum", "Pectus excavatum of inferior sternum", "Pedal edema", "Pediatric onset", "Pelvic girdle muscle weakness", "Pelvic kidney", "Pendular nystagmus", "Penetrating foot ulcers", "Peptic ulcer", "Perianal abscess", "Periauricular skin pits", "Pericardial effusion", "Pericarditis", "Perifoveal ring of hyperautofluorescence", "Perimembranous ventricular septal defect", "Periodic paralysis", "Periodontitis", "Periorbital edema", "Periorbital fullness", "Peripheral arterial stenosis", "Peripheral axonal degeneration", "Peripheral axonal neuropathy", "Peripheral cyanosis", "Peripheral demyelination", "Peripheral edema", "Peripheral hypermyelination", "Peripheral hypomyelination", "Peripheral neuropathy", "Peripheral opacification of the cornea", "Peripheral pulmonary artery stenosis", "Peripheral retinal avascularization", "Peripheral visual field loss", "Periportal fibrosis", "Perisylvian polymicrogyria", "Peritoneal abscess", "Peritonitis", "Periventricular cysts", "Periventricular heterotopia", "Periventricular leukomalacia", "Periventricular nodular heterotopia", "Periventricular white matter hyperintensities", "Peroneal muscle atrophy", "Perseveration", "Persistence of hemoglobin f", "Persistence of primary teeth", "Persistent ebv viremia", "Persistent head lag", "Personality changes", "Pes cavus", "Pes planus", "Pes valgus", "Petechiae", "Peters anomaly", "Phalangeal dislocation", "Pharyngitis", "Phenotypic variability", "Pheochromocytoma", "Phimosis", "Phocomelia", "Phonophobia", "Photophobia", "Photopsia", "Photoreceptor layer loss on macular oct", "Phthisis bulbi", "Physical urticaria", "Pierre robin sequence", "Pigmentary retinopathy", "Pili canaliculi", "Pili torti", "Pilomatrixoma", "Pineal cyst", "Pituitary adenoma", "Pituitary growth hormone cell adenoma", "Pituitary hypothyroidism", "Pituitary prolactin cell adenoma", "Plagiocephaly", "Plantar hyperkeratosis", "Platybasia", "Platyspondyly", "Pleural effusion", "Pleuritis", "Pneumonia", "Pneumothorax", "Poikilocytosis", "Poikiloderma", "Pointed chin", "Polar cataract", "Pollakisuria", "Polyarticular arthropathy", "Polyclonal elevation of igm", "Polycystic kidney dysplasia", "Polycystic liver disease", "Polycythemia", "Polydactyly", "Polygenic inheritance", "Polyhydramnios", "Polymicrogyria", "Polyneuropathy", "Polyphagia", "Polysplenia", "Polyuria", "Poor appetite", "Poor coordination", "Poor eye contact", "Poor fine motor coordination", "Poor gross motor coordination", "Poor head control", "Poor motor coordination", "Poor speech", "Poor suck", "Poor wound healing", "Porencephalic cyst", "Porokeratosis", "Porphyrinuria", "Portal fibrosis", "Portal vein thrombosis", "Positional foot deformity", "Positive romberg sign", "Post partum hemorrhage", "Postaxial foot polydactyly", "Postaxial hand polydactyly", "Postaxial polydactyly", "Posterior blepharitis", "Posterior embryotoxon", "Posterior fossa cyst", "Posterior pharyngeal cleft", "Posterior pituitary dysgenesis", "Posterior polar cataract", "Posterior subcapsular cataract", "Posteriorly rotated ears", "Postexertional malaise", "Postnatal growth retardation", "Postural instability", "Postural tremor", "Potter facies", "Preauricular skin tag", "Preaxial foot polydactyly", "Preaxial hand polydactyly", "Preaxial polydactyly", "Precocious atherosclerosis", "Predominantly lower limb lymphedema", "Prelingual sensorineural hearing impairment", "Premature adrenarche", "Premature arteriosclerosis", "Premature birth", "Premature coronary artery atherosclerosis", "Premature graying of hair", "Premature loss of primary teeth", "Premature loss of teeth", "Premature osteoarthritis", "Premature ovarian insufficiency", "Premature pubarche", "Premature rupture of membranes", "Premature skin wrinkling", "Premature thelarche", "Premature ventricular contraction", "Prematurely aged appearance", "Prenatal maternal abnormality", "Prenatal movement abnormality", "Primary adrenal insufficiency", "Primary amenorrhea", "Primary congenital glaucoma", "Primary gonadal insufficiency", "Primary hypercortisolism", "Primary hyperparathyroidism", "Primary microcephaly", "Primary peritoneal carcinoma", "Primitive neuroectodermal tumor", "Primitive reflex", "Productive cough", "Profound global developmental delay", "Profound hearing impairment", "Profound sensorineural hearing impairment", "Progeroid facial appearance", "Progressive", "Progressive cerebellar ataxia", "Progressive distal muscle weakness", "Progressive encephalopathy", "Progressive external ophthalmoplegia", "Progressive extrapyramidal movement disorder", "Progressive flexion contractures", "Progressive gait ataxia", "Progressive hearing impairment", "Progressive inability to walk", "Progressive leukoencephalopathy", "Progressive macrocephaly", "Progressive microcephaly", "Progressive muscle weakness", "Progressive neurologic deterioration", "Progressive night blindness", "Progressive peripheral neuropathy", "Progressive pes cavus", "Progressive proximal muscle weakness", "Progressive psychomotor deterioration", "Progressive pulmonary function impairment", "Progressive sensorineural hearing impairment", "Progressive spastic paraparesis", "Progressive spastic paraplegia", "Progressive spastic quadriplegia", "Progressive spasticity", "Progressive visual field defects", "Progressive visual loss", "Prolonged bleeding after dental extraction", "Prolonged bleeding after surgery", "Prolonged bleeding following circumcision", "Prolonged bleeding following procedure", "Prolonged bleeding time", "Prolonged neonatal jaundice", "Prolonged partial thromboplastin time", "Prolonged qtc interval", "Prominent antihelix", "Prominent antitragus", "Prominent crus of helix", "Prominent digit pad", "Prominent ear helix", "Prominent eyelashes", "Prominent forehead", "Prominent metopic ridge", "Prominent nasal bridge", "Prominent nasal tip", "Prominent nasolabial fold", "Prominent nose", "Prominent occiput", "Prominent sternum", "Prominent superficial blood vessels", "Prominent supraorbital ridges", "Prominent umbilicus", "Prominent veins on trunk", "Proportionate short stature", "Proportionate tall stature", "Proptosis", "Prostate neoplasm", "Protein avoidance", "Protein losing enteropathy", "Protruding ear", "Protruding tongue", "Protrusio acetabuli", "Protuberant abdomen", "Proximal amyotrophy", "Proximal femoral epiphysiolysis", "Proximal femoral metaphyseal abnormality", "Proximal femoral metaphyseal irregularity", "Proximal muscle weakness", "Proximal muscle weakness in lower limbs", "Proximal muscle weakness in upper limbs", "Proximal renal tubular acidosis", "Proximal symphalangism", "Proximal tubulopathy", "Proximal upper limb amyotrophy", "Pruritus", "Pseudoarthrosis", "Pseudobulbar paralysis", "Pseudobulbar signs", "Pseudoepiphyses", "Pseudoepiphyses of hand bones", "Pseudoepiphyses of the metacarpals", "Pseudohypoaldosteronism", "Pseudohypoparathyroidism", "Psoriasiform dermatitis", "Psychogenic non epileptic seizure", "Psychomotor deterioration", "Psychomotor retardation", "Psychosis", "Psychotic episodes", "Psychotic mentation", "Pterygium", "Ptosis", "Puberty and gonadal disorders", "Pulmonary artery dilatation", "Pulmonary artery hypoplasia", "Pulmonary artery stenosis", "Pulmonary carcinoid tumor", "Pulmonary cyst", "Pulmonary edema", "Pulmonary embolism", "Pulmonary fibrosis", "Pulmonary hemorrhage", "Pulmonary hypoplasia", "Pulmonary infiltrates", "Pulmonary insufficiency", "Pulmonary interstitial high resolution computed tomography abnormality", "Pulmonary venous hypertension", "Pulmonic stenosis", "Pulverulent cataract", "Punctate cataract", "Pure red cell aplasia", "Purpura", "Pustule", "Pyelonephritis", "Pyoderma gangrenosum", "Pyridoxine responsive sideroblastic anemia", "Quadriceps muscle weakness", "Radial bowing", "Radial deviation of the 2nd finger", "Radial deviation of the hand", "Radial deviation of the hand or of fingers of the hand", "Radioulnar dislocation", "Radioulnar synostosis", "Ragged red muscle fibers", "Rapidly progressive", "Raynaud phenomenon", "Reactive hypoglycemia", "Receptive language delay", "Rectal abscess", "Rectal fistula", "Rectal prolapse", "Recurrent", "Recurrent abscess formation", "Recurrent acute respiratory tract infection", "Recurrent aspergillus infections", "Recurrent aspiration pneumonia", "Recurrent bacterial infections", "Recurrent bacterial skin infections", "Recurrent bronchitis", "Recurrent bronchopulmonary infections", "Recurrent corneal erosions", "Recurrent cutaneous abscess formation", "Recurrent ear infections", "Recurrent fever", "Recurrent fractures", "Recurrent gastroenteritis", "Recurrent hand flapping", "Recurrent herpes", "Recurrent hypoglycemia", "Recurrent infection of the gastrointestinal tract", "Recurrent joint dislocation", "Recurrent lower respiratory tract infections", "Recurrent mycobacterial infections", "Recurrent opportunistic infections", "Recurrent otitis media", "Recurrent pancreatitis", "Recurrent paroxysmal headache", "Recurrent pharyngitis", "Recurrent pneumonia", "Recurrent respiratory infections", "Recurrent sinopulmonary infections", "Recurrent sinusitis", "Recurrent skin infections", "Recurrent staphylococcal infections", "Recurrent staphylococcus aureus infections", "Recurrent tonsillitis", "Recurrent upper and lower respiratory tract infections", "Recurrent urinary tract infections", "Recurrent viral infections", "Red eye", "Red green dyschromatopsia", "Red hair", "Reduced antigen specific t cell proliferation", "Reduced antithrombin iii activity", "Reduced brain n acetyl aspartate level by mrs", "Reduced c peptide level", "Reduced circulating prolactin concentration", "Reduced consciousness confusion", "Reduced delayed hypersensitivity", "Reduced factor viii activity", "Reduced factor xi activity", "Reduced factor xii activity", "Reduced factor xiii activity", "Reduced forced expiratory volume in one second", "Reduced forced vital capacity", "Reduced natural killer cell count", "Reduced pancreatic beta cells", "Reduced protein c activity", "Reduced protein s activity", "Reduced renal corticomedullary differentiation", "Reduced sperm motility", "Reduced subcutaneous adipose tissue", "Reduced systolic function", "Reduced tendon reflexes", "Reduced visual acuity", "Reduced vital capacity", "Reduction of neutrophil motility", "Redundant neck skin", "Redundant skin", "Refractory anemia", "Regional abnormality of skin", "Relative macrocephaly", "Renal agenesis", "Renal cell carcinoma", "Renal cortical cysts", "Renal cortical microcysts", "Renal corticomedullary cysts", "Renal cyst", "Renal duplication", "Renal dysplasia", "Renal fanconi syndrome", "Renal fibrosis", "Renal hamartoma", "Renal hypoplasia", "Renal hypoplasia aplasia", "Renal insufficiency", "Renal magnesium wasting", "Renal malrotation", "Renal phosphate wasting", "Renal potassium wasting", "Renal salt wasting", "Renal steatosis", "Renal tubular acidosis", "Renal tubular atrophy", "Renal tubular dysfunction", "Renal tubular epithelial necrosis", "Renovascular hypertension", "Repetitive compulsive behavior", "Respiratory alkalosis", "Respiratory arrest", "Respiratory distress", "Respiratory failure", "Respiratory failure requiring assisted ventilation", "Respiratory insufficiency", "Respiratory insufficiency due to defective ciliary clearance", "Respiratory paralysis", "Respiratory tract infection", "Response to drugs acting on neuromuscular transmission", "Resting tremor", "Restless legs", "Restlessness", "Restrictive behavior", "Restrictive cardiomyopathy", "Restrictive ventilatory defect", "Reticular hyperpigmentation", "Reticulated skin pigmentation", "Reticulocytopenia", "Reticulocytosis", "Retinal arteriolar tortuosity", "Retinal atrophy", "Retinal coloboma", "Retinal degeneration", "Retinal detachment", "Retinal dysplasia", "Retinal dystrophy", "Retinal fold", "Retinal hamartoma", "Retinal hemorrhage", "Retinal neovascularization", "Retinal perforation", "Retinal pigment epithelial atrophy", "Retinal pigment epithelial mottling", "Retinal telangiectasia", "Retinal thinning", "Retinal vascular tortuosity", "Retinopathy", "Retrocollis", "Retrognathia", "Rhabdomyolysis", "Rhabdomyosarcoma", "Rhegmatogenous retinal detachment", "Rheumatoid arthritis", "Rheumatoid factor positive", "Rhinitis", "Rhizomelia", "Rib fusion", "Rib segmentation abnormalities", "Rickets", "Ridged nail", "Rieger anomaly", "Right bundle branch block", "Right ventricular cardiomyopathy", "Right ventricular hypertrophy", "Rigidity", "Rimmed vacuoles", "Rod cone dystrophy", "Rotary nystagmus", "Round ear", "Round face", "Saccadic oscillation", "Saccadic smooth pursuit", "Sacrococcygeal teratoma", "Sagittal craniosynostosis", "Sandal gap", "Sarcoma", "Scaling skin", "Scanning speech", "Scaphocephaly", "Scapular winging", "Scarring", "Scarring alopecia of scalp", "Schistocytosis", "Schizencephaly", "Schizophrenia", "Schwannoma", "Scleral staphyloma", "Sclerocornea", "Scleroderma", "Sclerosis of hand bone", "Sclerosis of skull base", "Scotoma", "Scrotal hypoplasia", "Sea blue histiocytosis", "Seborrheic dermatitis", "Second degree atrioventricular block", "Secondary amenorrhea", "Secondary growth hormone deficiency", "Secondary microcephaly", "Secretory diarrhea", "Secundum atrial septal defect", "Segmental peripheral demyelination remyelination", "Selective tooth agenesis", "Self injurious behavior", "Self mutilation", "Semilobar holoprosencephaly", "Senile plaques", "Sensorimotor neuropathy", "Sensory ataxia", "Sensory axonal neuropathy", "Sensory neuropathy", "Sepsis", "Septate vagina", "Septic arthritis", "Septo optic dysplasia", "Serositis", "Severe b lymphocytopenia", "Severe combined immunodeficiency", "Severe cytomegalovirus infection", "Severe demyelination of the white matter", "Severe expressive language delay", "Severe failure to thrive", "Severe global developmental delay", "Severe hearing impairment", "Severe infection", "Severe intrauterine growth retardation", "Severe lactic acidosis", "Severe muscular hypotonia", "Severe photosensitivity", "Severe postnatal growth retardation", "Severe short limb dwarfism", "Severe short stature", "Severe varicella zoster infection", "Severe viral infection", "Severely reduced visual acuity", "Shagreen patch", "Shallow anterior chamber", "Shallow orbits", "Shawl scrotum", "Shield chest", "Shock", "Short 1st metacarpal", "Short attention span", "Short chin", "Short clavicles", "Short columella", "Short digit", "Short face", "Short femur", "Short foot", "Short fourth metatarsal", "Short lingual frenulum", "Short long bone", "Short lower limbs", "Short middle phalanx of finger", "Short nail", "Short nose", "Short palm", "Short palpebral fissure", "Short phalanx of the thumb", "Short philtrum", "Short proximal phalanx of finger", "Short ribs", "Short stepped shuffling gait", "Short sternum", "Short thorax", "Short thumb", "Short tibia", "Short umbilical cord", "Short upper lip", "Shortened pr interval", "Shortened qt interval", "Shortening of all distal phalanges of the fingers", "Shortening of all middle phalanges of the fingers", "Shoulder dislocation", "Shoulder girdle muscle atrophy", "Shoulder girdle muscle weakness", "Shoulder pain", "Shuffling gait", "Shyness", "Sideroblastic anemia", "Simple ear", "Simple febrile seizure", "Simplified gyral pattern", "Single fiber emg abnormality", "Single naris", "Single transverse palmar crease", "Single ventricle", "Sinus bradycardia", "Sinus tachycardia", "Sirenomelia", "Skeletal dysplasia", "Skeletal muscle atrophy", "Skeletal muscle hypertrophy", "Skeletal myopathy", "Skin appendage neoplasm", "Skin dimple", "Skin erosion", "Skin nodule", "Skin picking", "Skin pit", "Skin plaque", "Skin rash", "Skin tags", "Skin ulcer", "Skin vesicle", "Skull asymmetry", "Slanting of the palpebral fissure", "Sleep apnea", "Sleep disturbance", "Sleep wake cycle disturbance", "Slender build", "Slender finger", "Slender long bone", "Sloping forehead", "Slow decrease in visual acuity", "Slow pupillary light response", "Slow saccadic eye movements", "Slowly progressive", "Slurred speech", "Small anterior fontanelle", "Small basal ganglia", "Small earlobe", "Small epiphyses", "Small face", "Small for gestational age", "Small hand", "Small intestinal dysmotility", "Small nail", "Small pituitary gland", "Small placenta", "Smooth muscle antibody positivity", "Smooth philtrum", "Snoring", "Social and occupational deterioration", "Soft doughy skin", "Soft skin", "Soft tissue neoplasm", "Soft tissue sarcoma", "Solitary median maxillary central incisor", "Somatic mosaicism", "Somatic mutation", "Somatic sensory dysfunction", "Sound sensitivity", "Sparse and thin eyebrow", "Sparse body hair", "Sparse eyebrow", "Sparse eyelashes", "Sparse hair", "Sparse lateral eyebrow", "Sparse or absent eyelashes", "Sparse scalp hair", "Spastic ataxia", "Spastic diplegia", "Spastic dysarthria", "Spastic gait", "Spastic hyperactive bladder", "Spastic paraparesis", "Spastic paraparetic gait", "Spastic paraplegia", "Spastic tetraparesis", "Spastic tetraplegia", "Spasticity", "Specific learning disability", "Speech apraxia", "Speech articulation difficulties", "Spider hemangioma", "Spina bifida", "Spina bifida occulta", "Spinal canal stenosis", "Spinal cord compression", "Spinal cord lesion", "Spinal deformities", "Spinal muscular atrophy", "Spinal rigidity", "Splanchnic vein thrombosis", "Splenomegaly", "Split nail", "Spoken word recognition deficit", "Spondyloepimetaphyseal dysplasia", "Spondyloepiphyseal dysplasia", "Spondylolisthesis", "Spondylolysis", "Spontaneous abortion", "Spontaneous hemolytic crises", "Spontaneous pain sensation", "Spontaneous recurrent epistaxis", "Sporadic", "Spotty hyperpigmentation", "Spotty hypopigmentation", "Sprengel anomaly", "Squamous cell carcinoma", "Squamous cell carcinoma of the skin", "Square face", "Squared iliac bones", "St segment elevation", "Stage 5 chronic kidney disease", "Staring gaze", "Status epilepticus", "Status epilepticus with prominent motor symptoms", "Stenosis of the external auditory canal", "Steppage gait", "Stereotypical hand wringing", "Stereotypy", "Steroid resistant nephrotic syndrome", "Stiff skin", "Stillbirth", "Stomach cancer", "Stomatitis", "Stomatocytosis", "Stooped posture", "Streak ovary", "Striae distensae", "Stridor", "Stroke", "Stroke like episode", "Stuttering", "Subacute progressive viral hepatitis", "Subarachnoid hemorrhage", "Subcapsular cataract", "Subcortical band heterotopia", "Subcortical cerebral atrophy", "Subcortical heterotopia", "Subcutaneous hemorrhage", "Subcutaneous nodule", "Subdural hemorrhage", "Subependymal cysts", "Subglottic stenosis", "Submucous cleft of soft and hard palate", "Submucous cleft soft palate", "Subretinal fluid", "Subsarcolemmal accumulations of abnormally shaped mitochondria", "Substantia nigra gliosis", "Subvalvular aortic stenosis", "Sudden death", "Sudden episodic apnea", "Sudden loss of visual acuity", "Suicidal ideation", "Sunken cheeks", "Supernumerary bones of the axial skeleton", "Supernumerary nipple", "Supernumerary spleens", "Supernumerary tooth", "Supranuclear gaze palsy", "Supranuclear ophthalmoplegia", "Supravalvular aortic stenosis", "Supraventricular arrhythmia", "Supraventricular tachycardia", "Swan neck like deformities of the fingers", "Symphalangism affecting the phalanges of the hand", "Symphalangism of middle phalanx of finger", "Symptomatic seizures", "Syncope", "Syndactyly", "Synostosis involving bones of the hand", "Synostosis involving bones of the lower limbs", "Synostosis involving bones of the upper limbs", "Synostosis involving digits", "Synostosis of carpal bones", "Synostosis of carpals tarsals", "Synostosis of joints", "Synostosis of metacarpals metatarsals", "Synovitis", "Syringomyelia", "Systemic lupus erythematosus", "T cell lymphoma", "T lymphocytopenia", "Tachycardia", "Tachypnea", "Talipes calcaneovalgus", "Talipes equinovalgus", "Talipes equinovarus", "Talipes valgus", "Tall chin", "Tall stature", "Tapered distal phalanges of finger", "Tapered finger", "Tarsal synostosis", "Telangiectasia", "Telangiectasia of the skin", "Telecanthus", "Temperature instability", "Temporal cortical atrophy", "Temporal optic disc pallor", "Temporal pattern", "Tendon xanthomatosis", "Tented upper lip vermilion", "Teratoma", "Testicular adrenal rest tumor", "Testicular atrophy", "Testicular dysgenesis", "Tetany", "Tetralogy of fallot", "Tetraparesis", "Tetraplegia", "Tetraplegia tetraparesis", "Thenar muscle atrophy", "Thick cerebral cortex", "Thick corpus callosum", "Thick eyebrow", "Thick hair", "Thick lower lip vermilion", "Thick nasal alae", "Thick upper lip vermilion", "Thick vermilion border", "Thickened calvaria", "Thickened cortex of long bones", "Thickened ears", "Thickened helices", "Thickened nuchal skin fold", "Thickened ribs", "Thickened skin", "Thin bony cortex", "Thin clavicles", "Thin eyebrow", "Thin lower lip vermilion", "Thin nail", "Thin ribs", "Thin skin", "Thin upper lip vermilion", "Thin vermilion border", "Thinning of descemet membrane", "Third degree atrioventricular block", "Thoracic aortic aneurysm", "Thoracic hypoplasia", "Thoracic kyphoscoliosis", "Thoracic kyphosis", "Thoracic scoliosis", "Thoracolumbar kyphoscoliosis", "Thoracolumbar kyphosis", "Thoracolumbar scoliosis", "Thrombocytosis", "Thromboembolism", "Thyroid adenoma", "Thyroid carcinoma", "Thyroiditis", "Tibial bowing", "Tibial torsion", "Tics", "Tiger tail banding", "Tinnitus", "Tip toe gait", "Tissue ischemia", "Titubation", "Toe clinodactyly", "Toe syndactyly", "Toe walking", "Toenail dysplasia", "Tongue atrophy", "Tongue fasciculations", "Tongue nodules", "Tongue thrusting", "Tonic seizure", "Tooth malposition", "Torsade de pointes", "Torsion dystonia", "Total anomalous pulmonary venous return", "Toxemia of pregnancy", "Tracheal stenosis", "Tracheobronchomalacia", "Tracheoesophageal fistula", "Tracheomalacia", "Tractional retinal detachment", "Transient global amnesia", "Transient ischemic attack", "Transient neonatal diabetes mellitus", "Transient neutropenia", "Transposition of the great arteries", "Tremor", "Tremor by anatomical site", "Triangular face", "Triangular mouth", "Triangular shaped phalanges of the hand", "Triceps weakness", "Trichorrhexis nodosa", "Tricuspid atresia", "Tricuspid stenosis", "Tricuspid valve prolapse", "Trigonocephaly", "Triphalangeal thumb", "Trismus", "Tritanomaly", "Trophic changes related to pain", "Truncal ataxia", "Truncal obesity", "Truncal titubation", "Truncus arteriosus", "Tube feeding", "Tubulointerstitial nephritis", "Turricephaly", "Type 1 fibers relatively smaller than type 2 fibers", "Type 1 muscle fiber atrophy", "Type 2 muscle fiber atrophy", "Type 2 muscle fiber predominance", "Type i diabetes mellitus", "Type i transferrin isoform profile", "Type ii diabetes mellitus", "Type ii lissencephaly", "Type ii transferrin isoform profile", "Typical absence seizure", "U shaped upper lip vermilion", "Ulcerative colitis", "Ulnar bowing", "Ulnar claw", "Ulnar deviation of finger", "Ulnar deviation of the 2nd finger", "Ulnar deviation of the hand", "Ulnar deviation of the hand or of fingers of the hand", "Ulnar deviation of the wrist", "Uncombable hair", "Unconjugated hyperbilirubinemia", "Uncontrolled eye movements", "Underdeveloped nasal alae", "Underdeveloped supraorbital ridges", "Underdeveloped tragus", "Undetectable electroretinogram", "Undetectable light and dark adapted electroretinogram", "Undetectable visual evoked potentials", "Unexplained fevers", "Unilateral ptosis", "Unilateral renal agenesis", "Unsteady gait", "Unusual fungal infection", "Unusual infection", "Unusual infection by anatomical site", "Upgaze palsy", "Upper airway obstruction", "Upper extremity joint dislocation", "Upper eyelid coloboma", "Upper limb amyotrophy", "Upper limb asymmetry", "Upper limb hypertonia", "Upper limb muscle weakness", "Upper limb pain", "Upper limb postural tremor", "Upper limb spasticity", "Upper limb undergrowth", "Upper motor neuron dysfunction", "Upslanted palpebral fissure", "Ureteral duplication", "Ureteral obstruction", "Ureteral stenosis", "Ureterocele", "Ureteropelvic junction obstruction", "Urethral obstruction", "Urethral stenosis", "Urethral stricture", "Urethral valve", "Uric acid nephrolithiasis", "Urinary bladder sphincter dysfunction", "Urinary glycosaminoglycan excretion", "Urinary incontinence", "Urinary retention", "Urinary tract neoplasm", "Urinary urgency", "Urogenital fistula", "Urogenital sinus anomaly", "Urticaria", "Uterine prolapse", "Uterus didelphys", "Uveal melanoma", "Uveitis", "Vacuolated lymphocytes", "Vaginal atresia", "Vaginal fistula", "Vaginal neoplasm", "Variable expressivity", "Varicose veins", "Vascular calcification", "Vascular dilatation", "Vascular neoplasm", "Vascular skin abnormality", "Vascular tortuosity", "Vasculitis", "Vegetative state", "Vein of galen aneurysmal malformation", "Velopharyngeal insufficiency", "Venous insufficiency", "Venous malformation", "Venous thrombosis", "Ventricular arrhythmia", "Ventricular escape rhythm", "Ventricular fibrillation", "Ventricular hypertrophy", "Ventricular preexcitation", "Ventricular septal hypertrophy", "Ventricular tachycardia", "Ventriculomegaly", "Verrucae", "Vertebral arch anomaly", "Vertebral clefting", "Vertebral compression fracture", "Vertebral fusion", "Vertebral hypoplasia", "Vertebral segmentation defect", "Vertebral wedging", "Vertical nystagmus", "Vertical supranuclear gaze palsy", "Vertigo", "Very long chain fatty acid accumulation", "Vestibular dysfunction", "Viral encephalitis", "Viral hepatitis", "Viral infection induced rhabdomyolysis", "Visceral angiomatosis", "Visual acuity test abnormality", "Visual agnosia", "Visual field defect", "Visual fixation instability", "Visual hallucinations", "Visual impairment", "Visual loss", "Vitamin b12 deficiency", "Vitiligo", "Vitreoretinopathy", "Vitreous floaters", "Vitreous hemorrhage", "Vitritis", "Vocal cord paralysis", "Vocal cord paresis", "Volvulus", "Vomiting", "Waddling gait", "Weak cry", "Weak voice", "Weakness due to upper motor neuron dysfunction", "Weakness of facial musculature", "Weakness of long finger extensor muscles", "Weakness of muscles of respiration", "Weakness of the intrinsic hand muscles", "Webbed neck", "Weight loss", "Wheezing", "White forelock", "White hair", "Wide anterior fontanel", "Wide cranial sutures", "Wide intermamillary distance", "Wide mouth", "Wide nasal bridge", "Wide nasal ridge", "Wide nose", "Widely patent fontanelles and sutures", "Widely spaced incisors", "Widely spaced teeth", "Widened cerebral subarachnoid space", "Widened subarachnoid space", "Widow s peak", "Woolly hair", "Wormian bones", "Wrist flexion contracture", "Writer s cramp", "X linked dominant inheritance", "X linked recessive inheritance", "Xanthelasma", "Xanthomatosis", "Xerostomia", "Y shaped metacarpals", "Yellow white lesions of the retina", "Young adult onset", "Zonular cataract"], "available_proteins": ["AAAS", "AARS", "AARS2", "AASS", "ABCB1", "ABCB7", "ABCD3", "ABHD12", "ACACA", "ACAD9", "ACADM", "ACADVL", "ACAT1", "ACAT2", "ACBD5", "ACO2", "ACOX1", "ACP2", "ACSL4", "ACTN1", "ACTN2", "ACTN4", "ADA", "ADAR", "ADD1", "ADD3", "ADH5", "ADK", "ADNP", "ADPRHL2", "ADSL", "AFG3L2", "AGK", "AGL", "AGPS", "AHCY", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AKT2", "ALDH18A1", "ALDH2", "ALDH3A2", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDOA", "ALG1", "ANAPC1", "ANK3", "ANKFY1", "ANKLE2", "ANLN", "ANXA11", "AP1B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "APC", "APOL2", "APP", "APPL1", "APRT", "ARCN1", "ARHGDIA", "ARHGEF1", "ARHGEF2", "ARID1A", "ARL2", "ARL3", "ARL6IP1", "ASAH1", "ASNA1", "ASNS", "ASPH", "ATAD1", "ATAD3A", "ATG7", "ATIC", "ATP1A1", "ATP2A2", "ATP5A1", "ATP6AP1", "ATP6V0A2", "ATP6V1A", "ATP6V1B2", "ATP6V1E1", "ATXN10", "AURKA", "B3GALT6", "B4GAT1", "BANF1", "BAZ1B", "BCAP31", "BCS1L", "BICD2", "BLVRA", "BMS1", "BPTF", "BRAT1", "BRD4", "BUB1", "BUB1B", "BUB3", "C19orf70", "C1QBP", "CAD", "CALD1", "CALM3", "CALR", "CAMK2G", "CAPN1", "CARS", "CARS2", "CASK", "CASP8", "CAST", "CCDC22", "CCDC47", "CCT5", "CD2AP", "CD3EAP", "CDC40", "CDC42", "CDC45", "CDC73", "CDK4", "CDK6", "CEP55", "CERS1", "CFL2", "CHAMP1", "CHD1", "CHD4", "CHEK2", "CHMP1A", "CHMP2B", "CHORDC1", "CHST14", "CISD2", "CIZ1", "CLASP1", "CLCC1", "CLN5", "CLPB", "CLPP", "CLPX", "CLTC", "CNNM4", "CNOT1", "CNP", "COA3", "COA7", "COASY", "COG2", "COG6", "COLEC12", "COLGALT1", "COMT", "COPA", "COPB1", "COPB2", "COQ8A", "COQ9", "COX15", "COX2", "COX4I1", "COX5A", "CPNE1", "CPOX", "CPSF1", "CPT1A", "CPT2", "CRKL", "CRTAP", "CSNK2B", "CSTB", "CTBP1", "CTNNA1", "CTNNB1", "CTNND1", "CTPS1", "CTSA", "CTSC", "CUL3", "CUL4B", "CWF19L1", "CYB5R3", "CYC1", "DARS", "DARS2", "DCPS", "DCTN1", "DCTN4", "DCXR", "DDB1", "DDOST", "DDRGK1", "DDX3X", "DDX41", "DDX6", "DHCR24", "DHCR7", "DHFR", "DHPS", "DHX16", "DHX30", "DHX37", "DHX38", "DIABLO", "DIAPH1", "DIAPH3", "DICER1", "DIP2B", "DKC1", "DLAT", "DLD", "DLST", "DNAAF5", "DNAJC3", "DNM1L", "DNM2", "DNMT1", "DOCK7", "DPF2", "DPP9", "DSG2", "DSP", "DST", "DYNC1H1", "DYNC1I2", "DYNLL1", "EARS2", "EBP", "ECE1", "ECHS1", "EDC3", "EEF1A2", "EEF2", "EFL1", "EFTUD2", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF3F", "EIF4A3", "EIF4G1", "EIF4H", "EIF5A", "ELAC2", "ELP1", "ELP2", "EMC1", "EMD", "EMG1", "EPB41", "EPHX2", "EPRS", "EPS15L1", "ERAL1", "ERAP1", "ERCC2", "ERCC3", "ERLIN1", "ERLIN2", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXOC2", "EXOC7", "EXOSC3", "EXOSC8", "EZR", "FAH", "FAM50A", "FANCI", "FAR1", "FARSA", "FARSB", "FASN", "FASTKD2", "FBXO7", "FDFT1", "FDPS", "FDXR", "FECH", "FH", "FHL1", "FIP1L1", "FKBP10", "FKBP14", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FMR1", "FOXC1", "FOXRED1", "FSCN1", "FTO", "FTSJ1", "FUCA1", "FUS", "FXR1", "G6PD", "GAA", "GALK1", "GALNT2", "GANAB", "GAPVD1", "GARS", "GATAD2B", "GATB", "GATC", "GBA", "GBE1", "GCDH", "GDAP1", "GDI1", "GEMIN4", "GEMIN5", "GFM1", "GFPT1", "GGCX", "GIGYF2", "GLA", "GLB1", "GLDC", "GLMN", "GLRX5", "GLS", "GLUD1", "GM2A", "GMPPA", "GMPPB", "GNAI2", "GNAI3", "GNS", "GOT2", "GPD2", "GPHN", "GPI", "GPKOW", "GPT2", "GRHPR", "GSR", "GSS", "GSTM3", "GTF2I", "GTPBP3", "GUSB", "GYG1", "H2AFY", "HADH", "HADHA", "HADHB", "HCCS", "HCFC1", "HELLS", "HEXA", "HEXB", "HIBCH", "HIST1H1E", "HK1", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HMBS", "HMGA1", "HMGB3", "HMGCL", "HMOX1", "HNRNPA1", "HNRNPA2B1", "HNRNPDL", "HNRNPH2", "HNRNPK", "HNRNPU", "HPRT1", "HS2ST1", "HSD17B10", "HSD17B4", "HSPA9", "HSPB1", "HSPD1", "HTT", "HUWE1", "HYOU1", "IARS", "IARS2", "IBA57", "IDH1", "IDH2", "IDH3A", "IDH3B", "IFT27", "IGBP1", "IGF2BP2", "IGF2R", "IMPDH1", "INF2", "IRS4", "ITCH", "ITPA", "IVD", "JUP", "KARS", "KDM1A", "KDM3B", "KDSR", "KIAA0319L", "KIF11", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF4A", "KIFBP", "KLC2", "L2HGDH", "LAMP2", "LARP7", "LARS", "LARS2", "LAS1L", "LBR", "LDHA", "LDLR", "LEMD2", "LEMD3", "LETM1", "LIPA", "LLGL1", "LMAN1", "LMNA", "LMNB1", "LMNB2", "LNPK", "LONP1", "LPP", "LRBA", "LRPAP1", "LRPPRC", "LSS", "LZTFL1", "MACF1", "MAD1L1", "MAGED2", "MAGT1", "MAP1B", "MAP2K1", "MAP2K2", "MAPK1", "MAPRE2", "MARS", "MARS2", "MAT2A", "MATR3", "MBOAT7", "MCCC1", "MCCC2", "MCM2", "MCM4", "MCM5", "MCM6", "MCM7", "MDH1", "MDH2", "MECP2", "MESD", "MFN2", "MGME1", "MIA3", "MICU1", "MID1", "MIF", "MINPP1", "MIPEP", "MMAB", "MOGS", "MPDU1", "MPI", "MRE11", "MRPL12", "MRPL44", "MRPS2", "MRPS22", "MRPS23", "MRPS25", "MRPS34", "MRPS35", "MRPS7", "MSH2", "MSH3", "MSH6", "MSMO1", "MSN", "MSTO1", "MTAP", "MTCH1", "MTHFD1", "MTOR", "MTPAP", "MTR", "MTX2", "MUT", "MYH14", "MYH9", "MYO6", "NAA10", "NAA15", "NADK2", "NAGLU", "NANS", "NARS", "NAXE", "NBN", "NCAPD2", "NCAPH", "NCDN", "NCSTN", "NDUFA10", "NDUFA11", "NDUFA13", "NDUFA2", "NDUFA4", "NDUFA8", "NDUFA9", "NDUFAF4", "NDUFB10", "NDUFB11", "NDUFB3", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS7", "NDUFS8", "NDUFV1", "NDUFV2", "NEFL", "NEK9", "NELFA", "NEMF", "NFKB1", "NFS1", "NHLRC2", "NHP2", "NNT", "NONO", "NOP10", "NOP56", "NPC1", "NPM1", "NSD2", "NSDHL", "NSF", "NSUN2", "NT5C2", "NUBPL", "NUMA1", "NUP107", "NUP133", "NUP155", "NUP160", "NUP188", "NUP205", "NUP214", "NUP37", "NUP62", "NUP85", "NUP88", "NUP93", "NXN", "OAT", "OCLN", "OGDH", "OGT", "OPA1", "OPA3", "OSGEP", "P3H1", "P4HA2", "P4HB", "PABPN1", "PAFAH1B1", "PAK1", "PALLD", "PARK7", "PARN", "PBRM1", "PC", "PCBD1", "PCCA", "PCCB", "PCK2", "PCNA", "PDCD6", "PDE6D", "PDHA1", "PDHB", "PDK3", "PDXK", "PEPD", "PEX14", "PEX19", "PEX5", "PFKM", "PFN1", "PGK1", "PGM1", "PHB", "PHF6", "PHF8", "PHGDH", "PICALM", "PIGK", "PIGS", "PISD", "PITRM1", "PKN1", "PLAA", "PLD3", "PLEC", "PLOD1", "PLOD2", "PLOD3", "PLS3", "PMPCA", "PMPCB", "PNP", "PNPLA8", "PNPT1", "POFUT1", "POGZ", "POLA1", "POLD1", "POLE", "POLR1A", "POLR1B", "POLR1C", "POLR2A", "POLR3A", "PON2", "POP1", "POR", "PPA2", "PPIB", "PPIL1", "PPOX", "PPP1CB", "PPP1R12A", "PPP2R1A", "PPP2R1B", "PPP2R5D", "PPT1", "PQBP1", "PRCC", "PREPL", "PRKACA", "PRKAR1A", "PRKCSH", "PRKDC", "PRKRA", "PRPF3", "PRPF31", "PRPF4", "PRPF6", "PRPF8", "PSAP", "PSAT1", "PSMB4", "PSMC3", "PSMD12", "PTCD3", "PTDSS1", "PTPN1", "PTRH2", "PUF60", "PUM1", "PURA", "PUS7", "PXMP2", "PYCR1", "PYCR2", "PYGL", "QARS", "QDPR", "QRSL1", "RAB11B", "RAB18", "RAB3GAP1", "RAB3GAP2", "RAB7A", "RAC1", "RAD21", "RAD50", "RALA", "RANBP2", "RAPGEF2", "RARS", "RARS2", "RBM10", "RBM12", "RBM28", "RBM8A", "RBMX", "RDH11", "RDX", "REPS1", "RFC1", "RFC2", "RHOA", "RINT1", "RIPK1", "RNASEH2A", "RNASET2", "RP2", "RPL10", "RPL11", "RPL13", "RPL15", "RPL18", "RPL21", "RPL27", "RPL31", "RPL35", "RPL35A", "RPL5", "RPS10", "RPS14", "RPS15A", "RPS17", "RPS19", "RPS20", "RPS23", "RPS24", "RPS28", "RPS6KA3", "RPS7", "RPSA", "RTN2", "RTN4IP1", "SAMHD1", "SARS", "SARS2", "SBDS", "SC5D", "SCAF1", "SCARB2", "SCO1", "SCO2", "SCP2", "SDHA", "SDHB", "SEC23A", "SEC23B", "SEC24C", "SEC31A", "SEC61A1", "SEC63", "SEPT9", "SERPINB6", "SERPINH1", "SET", "SETD2", "SF3B1", "SF3B4", "SFXN4", "SGPL1", "SH3GL1", "SHMT2", "SHOC2", "SIGMAR1", "SKIV2L", "SLC16A1", "SLC19A1", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A20", "SLC25A22", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A4", "SLC27A4", "SLC2A1", "SLC33A1", "SLC9A3R1", "SLTM", "SMARCA4", "SMARCAD1", "SMARCC2", "SMARCE1", "SMC1A", "SMC3", "SMCHD1", "SMN1*", "SMPD4", "SNAP29", "SNRNP200", "SNRPE", "SOAT1", "SON", "SORD", "SPART", "SPECC1L", "SPEN", "SPR", "SPTAN1", "SPTBN1", "SPTBN2", "SPTLC1", "SPTLC2", "SQSTM1", "SRP54", "SRP72", "SSBP1", "SSR4", "STAG1", "STAG2", "STAMBP", "STARD7", "STAT1", "STAT3", "STK4", "STT3A", "STUB1", "SUCLA2", "SUCLG1", "SUZ12", "SYNE2", "TAF15", "TALDO1", "TARDBP", "TARS", "TARS2", "TBCD", "TBCE", "TCOF1", "TDP2", "TECR", "TELO2", "TERF2IP", "TFAM", "TFG", "TFRC", "THOC2", "THOC6", "TIA1", "TIMM50", "TKFC", "TKT", "TMCO1", "TMEM126A", "TMEM165", "TMEM199", "TMEM43", "TMPO", "TMPO", "TMTC3", "TMX2", "TNPO3", "TOE1", "TOMM40", "TOP2A", "TOR1AIP1", "TP53", "TPI1", "TPM1", "TPM3", "TPP1", "TPP2", "TRIM28", "TRIP12", "TRIP13", "TRMT10C", "TSFM", "TTC19", "TTC37", "TUBB", "TUBB2A", "TUBB2B", "TUBB4A", "TUBB4B", "TUBB6", "TUBGCP2", "TUFM", "UBA1", "UBE3A", "UBE4B", "UBTF", "UFC1", "UFD1", "UFM1", "UGDH", "UGP2", "UMPS", "UNC119", "UNC45A", "UNG", "UQCRB", "UQCRC1", "UQCRC2", "UQCRQ", "UROD", "USMG5", "USP7", "USP9X", "VAMP7", "VANGL1", "VAPB", "VARS1", "VARS2", "VCL", "VCP", "VIM", "VIPAS39", "VPS33A", "VPS33B", "VPS35", "VRK1", "WARS", "WASHC4", "WBP11", "WDR1", "WDR36", "WFS1", "WIPI2", "WNK1", "XPNPEP3", "XRCC1", "YARS", "YARS2", "YME1L1", "YWHAE", "YWHAG", "ZC3H14", "ZCCHC8", "ZFR", "ZMPSTE24", "ZPR1"], "leading_proteins": ["AAAS", "AARS2", "ABCB1", "ABCB7", "ABCD3", "ACAD9", "ACAT2", "ACOX1", "ACSL4", "ADA", "ADH5", "ADK", "AGPS", "AIFM1", "AIP", "AKT2", "ALDH18A1", "ALDH3A2", "ALG1", "ANAPC1", "ANKLE2", "APC", "APOL2", "APP", "APPL1", "ARL6IP1", "ASNA1", "ATAD1", "ATAD3A", "ATG7", "ATP1A1", "ATP2A2", "ATP6AP1", "ATP6V0A2", "ATXN10", "B3GALT6", "BAZ1B", "BCAP31", "BCS1L", "BICD2", "BLVRA", "BRAT1", "C19orf70", "CAMK2G", "CASK", "CCDC47", "CDK4", "CERS1", "CHST14", "CLCC1", "CLN5", "CNNM4", "COA3", "COA7", "COASY", "COG2", "COMT", "COPB2", "COX15", "COX4I1", "CPOX", "CPT2", "CRTAP", "CTBP1", "CTPS1", "CTSA", "CTSC", "DARS2", "DDRGK1", "DDX3X", "DHCR24", "DHCR7", "DHPS", "DHX16", "DNM1L", "DNM2", "DPP9", "DYNC1I2", "EBP", "ECE1", "EIF2B2", "EIF2B3", "EIF2B5", "EIF4H", "EMD", "EMG1", "ERCC2", "ERCC3", "ERLIN2", "EWSR1", "EXOSC3", "FAH", "FARSA", "FASN", "FDFT1", "FDPS", "FKBP10", "FKBP14", "FLII", "FMR1", "FOXRED1", "FSCN1", "FUCA1", "FUS", "GAA", "GALNT2", "GAPVD1", "GBA", "GDAP1", "GGCX", "GLB1", "GLRX5", "GLUD1", "GMPPB", "GPD2", "GPKOW", "GTF2I", "GUSB", "GYG1", "HADH", "HADHA", "HCCS", "HEXA", "HLA-B", "HMBS", "HMOX1", "HNRNPA1", "HNRNPA2B1", "HNRNPDL", "HNRNPH2", "HNRNPK", "HS2ST1", "HSD17B4", "HTT", "HYOU1", "IBA57", "IGBP1", "IGF2BP2", "IRS4", "ITCH", "KDSR", "KIAA0319L", "KIF22", "KIFBP", "KLC2", "LBR", "LDLR", "LETM1", "LMNA", "LMNB1", "LMNB2", "LONP1", "LRBA", "LSS", "MAP2K1", "MAP2K2", "MAPRE2", "MATR3", "MBOAT7", "MCCC2", "MCM6", "MFN2", "MGME1", "MINPP1", "MIPEP", "MMAB", "MOGS", "MPDU1", "MSMO1", "MSTO1", "MTAP", "MTCH1", "MTOR", "MTPAP", "MTR", "MTX2", "MYH9", "NAA10", "NAGLU", "NDUFA11", "NDUFA13", "NDUFB10", "NDUFB11", "NDUFB3", "NDUFB9", "NDUFS2", "NEFL", "NEK9", "NNT", "NONO", "NPC1", "NSD2", "NSUN2", "NUP107", "NUP205", "NUP37", "NUP88", "NUP93", "OCLN", "OPA1", "OPA3", "P3H1", "PAK1", "PARN", "PCBD1", "PCCB", "PDE6D", "PDK3", "PEX14", "PEX19", "PEX5", "PHF6", "PHF8", "PIGK", "PITRM1", "PLAA", "PLD3", "PMPCA", "PNPT1", "PON2", "POP1", "POR", "PPT1", "PRKCSH", "PSAP", "PSMB4", "PTDSS1", "PUF60", "PUM1", "PXMP2", "PYGL", "QRSL1", "RBM10", "RBM8A", "RBMX", "RFC2", "RINT1", "RIPK1", "RPL10", "RPS10", "RPS23", "RPS28", "RTN2", "RTN4IP1", "SARS2", "SC5D", "SCARB2", "SCO2", "SDHB", "SEC63", "SET", "SF3B1", "SFXN4", "SGPL1", "SIGMAR1", "SLC19A1", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A13", "SLC25A15", "SLC25A20", "SLC25A22", "SLC25A24", "SLC25A26", "SLC25A32", "SLC27A4", "SLC2A1", "SMC3", "SMN1*", "SMPD4", "SOAT1", "SPART", "SPR", "SPTLC1", "SSR4", "STARD7", "STAT1", "STK4", "STT3A", "TAF15", "TARS2", "TBCE", "TECR", "TIA1", "TIMM50", "TMCO1", "TMEM126A", "TMEM165", "TMEM199", "TMEM43", "TMPO", "TMX2", "TNPO3", "TOMM40", "TPM1", "TPP1", "TTC37", "TUBB4A", "TUBGCP2", "UBE3A", "UFM1", "UGDH", "UNC119", "UNG", "UQCRC1", "UQCRC2", "UQCRQ", "USMG5", "USP9X", "VAMP7", "VANGL1", "VCP", "VIM", "VIPAS39", "VPS33A", "VPS33B", "WFS1", "XPNPEP3", "YME1L1", "ZMPSTE24", "ZPR1"]} \ No newline at end of file diff --git a/msigdb_kegg/advanced/idx2term.json b/msigdb_kegg/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..d72055a8a164a290027c6907f1e024b192a96ceb --- /dev/null +++ b/msigdb_kegg/advanced/idx2term.json @@ -0,0 +1 @@ +{"0": "Parkinsons disease", "1": "Porphyrin and chlorophyll metabolism", "2": "Glycerophospholipid metabolism", "3": "Oxidative phosphorylation", "4": "Biosynthesis of 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setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Parkinsons disease 13 52 2.538915675272288 0.0111196620942157 16.90776699029126 54.04126213592233 1.0315348591123816 0.3152611195514452 7.595108151251147 4.223805209268991 1.8494970521239744 0.3626807692210581 0.0027272298197333 0.0014681613257241 6.0829140550034186e-05 0.0124287342519901 0.0001306204535395 +Porphyrin and chlorophyll metabolism 7 15 2.4381385295020586 0.0147631152680145 3.728155339805826 13.315533980582524 1.2215621624941897 0.2689555702886888 1.770547470360957 1.4201912411596824 1.0389071586082248 0.2908939383930566 0.0004132401328629 1.0 0.0158256043387446 0.0011993766429203 2.789873905099777e-05 +Glycerophospholipid metabolism 5 13 2.2999920386924075 0.0214486710880024 5.553398058252427 16.104368932038835 0.8448777148315795 0.3373638196000335 3.045697762577092 2.514285464673758 1.2272389207362138 0.3056726473181033 0.0753815714723636 1.0 0.0154029461510805 0.1423397245441582 0.0465202107555725 +Oxidative phosphorylation 13 56 2.277781989618058 0.0227395699085741 18.79854368932039 59.0752427184466 1.0149760730411637 0.3252836463038503 7.263801581344288 4.652138947381941 1.8018345229041028 0.3643612228552857 0.0027272298197333 0.0014681613257241 6.0829140550034186e-05 0.0034761042108243 0.0001306204535395 +Biosynthesis of unsaturated fatty acids 7 9 2.250289512274139 0.0244305732572307 3.866504854368932 9.87135922330097 0.446353222362544 0.4068046635290026 2.037070144655868 1.3349139447509937 1.1010511542611248 0.297846720070728 0.0004132401328629 1.0 0.1774332758731671 0.0011993766429203 2.789873905099777e-05 +Lysosome 14 46 1.9830315122264413 0.0473639097238871 21.740291262135923 48.609223300970875 0.8281821627988494 0.1302152537326229 7.142313942893836 4.247239237941681 3.086075071395461 0.2389623217115766 0.0004386085865073 0.0118453859760169 0.0155950844685177 0.000136353407796 2.1183635638671503e-05 diff --git a/msigdb_kegg/metrics.json b/msigdb_kegg/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..ea3168195fe3492fce9b6c305241bb387d7cf73b --- /dev/null +++ b/msigdb_kegg/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2734, + "annotations_size": 178, + "title": "Average number of proteins per term", + "value": 15.129213483146067 +} \ No newline at end of file diff --git a/msigdb_kegg/paths.json b/msigdb_kegg/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..505b77e1edb146fdcaaa29052e3c9334e330ca12 --- /dev/null +++ b/msigdb_kegg/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/msigdb_kegg/fragment/C166/C166_val_log2fc"} \ No newline at end of file diff --git a/msigdb_kegg/result.tsv b/msigdb_kegg/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..4017a9461f864025c6307c2e3da839c683c1f1e5 --- /dev/null +++ b/msigdb_kegg/result.tsv @@ -0,0 +1,67 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Glycosaminoglycan biosynthesis chondroitin sulfate 0.9267935578330906 3.100054807774148 0.0019348483626939 0.2915930928415676 0.086579204925394 2 Q8NCH0 1 +Glycosaminoglycan biosynthesis heparan sulfate 0.9264275256222544 3.098413113137906 0.001945600110683 0.2929501839115643 0.086579204925394 2 Q96L58 1 +Steroid hormone biosynthesis 0.8770131771595935 2.87380434760643 0.0040556011587542 0.5148828347576025 0.1371672517136112 2 P21964 1 +Parkinsons disease 0.4907687035326531 2.538915675272288 0.0111196620942157 0.8633574231007937 0.1708804304813256 52 Q9Y277,P13073,O95168,P21796,P14406,P21912,O14949,O75306,P45880,O96000,P60604,O43676,Q9UDW1 13 +Primary immunodeficiency 0.8045387994143487 2.5333510110708355 0.0112977756693515 0.8676691825045277 0.1708804304813256 2 P00813 1 +Porphyrin and chlorophyll metabolism 0.6805245555002516 2.4381385295020586 0.0147631152680145 0.9291666313410372 0.1877024655504707 15 P36551,P09601,P30043,Q7KZN9,P08236,P30519,Q96EY8 7 +Pantothenate and coa biosynthesis 0.7730600292825802 2.381285522116564 0.0172523340036627 0.9548477135215416 0.1932451985815217 2 Q13057 1 +Glycerophospholipid metabolism 0.6948112147595796 2.2999920386924075 0.0214486710880024 0.978919409611039 0.2121035252035794 13 Q8NCC3,Q9HCL2,P35790,Q96N66,P43304 5 +Oxidative phosphorylation 0.4600057209147757 2.277781989618058 0.0227395699085741 0.9833338249718973 0.2130338654592738 56 Q93050,Q86Y39,P13073,O95168,O75964,P14406,P21912,O14949,O75306,O96000,Q9Y487,O43676,Q9UDW1 13 +Biosynthesis of unsaturated fatty acids 0.8119379357714799 2.250289512274139 0.0244305732572307 0.9877550697396918 0.2174321019893536 9 O95864,Q15067,O15254,Q53GQ0,Q9BY49,P40939,O00767 7 +Alpha linolenic acid metabolism 0.8235078725741487 2.174190588582818 0.0296908248863754 0.9953225993739264 0.2516650871321345 3 O15254,Q15067 2 +Lysosome 0.4426290176516451 1.9830315122264417 0.0473639097238871 0.9998225763771992 0.3242606127250736 46 Q93050,P53634,Q8NCC3,P50897,Q14108,Q9NZJ7,O15118,P08236,P54802,P07602,O43681,P04062,Q9Y487,O75503 14 +Sphingolipid metabolism 0.7207708721715688 1.9379609158264868 0.052627991091702 0.99993383052269 0.3247352761867742 10 Q06136,O43681,P04062,O95470 4 +Huntingtons disease 0.3967629158131508 1.906734168199144 0.0565550200100561 0.9999684099088976 0.3247352761867742 71 Q9Y277,P13073,O95168,P21796,P14406,P21912,O14949,O75306,P45880,O96000,O43676,Q9UDW1 12 +Protein export 0.5907508182971245 1.8046728110689232 0.0711258968665906 0.9999980215722852 0.3723649894780334 14 Q99442,Q15070,Q9Y5M8,P67812 4 +Steroid biosynthesis 0.6233408517294123 1.7188978832330917 0.0856329676716902 0.9999998799230854 0.4234074512655796 12 Q15125,Q15800,Q16850,P37268,Q15392,P48449,Q14534 7 +Vibrio cholerae infection 0.5233892229564931 1.691917964228839 0.090661616279227 0.9999999550071867 0.436155883721687 18 Q93050,Q9Y487 2 +Alzheimers disease 0.3967400298224993 1.592668296743481 0.1112346232804866 0.9999999992342116 0.485619656209268 56 P13073,O95168,P14406,P21912,O14949,O75306,O96000,P05067,P16615,O43676,Q9UDW1 11 +Snare interactions in vesicular transport 0.6295646290154806 1.589905033305333 0.1118562129470785 0.9999999993238792 0.485619656209268 11 O15400,Q9P2W9,Q86Y82,P51809,Q13190,Q9UEU0 6 +Calcium signaling pathway 0.5294818370338413 1.4272460591100595 0.1535089825788929 0.9999999999998692 0.5983067774023474 14 Q9Y277,P21796,P45880,P16615,Q13555 5 +Abc transporters 0.7313018160454245 1.4082237613508757 0.1590648223953581 0.9999999999999596 0.5983067774023474 4 P08183,O75027 2 +Cardiac muscle contraction 0.4714750990348124 1.357368646645324 0.1746641053257482 0.9999999999999986 0.6123200076135542 19 O14949,P16615,P13073,Q9UDW1 4 +Renin angiotensin system 0.7157509157509165 1.342161817190222 0.1795435338566899 0.9999999999999994 0.6123200076135542 4 Q9BYT8,Q9UIQ6,P10619 3 +Amyotrophic lateral sclerosis als 0.577162479603221 1.3050111060165717 0.1918890660794603 1.0 0.6123200076135542 11 Q9BUN8,O96008,P07197 3 +B cell receptor signaling pathway 0.6131340532892217 1.2801945889822888 0.2004767084864127 1.0 0.6123200076135542 9 P62993,P31751 2 +Ppar signaling pathway 0.4937817169219186 1.2780731903351243 0.2012236208811799 1.0 0.6123200076135542 15 O15254,O00767,P23786 3 +Hypertrophic cardiomyopathy hcm 0.6261670261422909 1.2476273734857029 0.2121675491619039 1.0 0.6294303958469817 8 P09493,P16615,P50402 3 +Erbb signaling pathway 0.5093409737917001 1.2160230777584682 0.2239761309446688 1.0 0.6463053430637616 13 P62993,P31751,Q13555,P36507 4 +Dilated cardiomyopathy 0.6088829441853066 1.1636558545577016 0.2445635062886273 1.0 0.6595803654450858 8 P09493,P16615,P50402 3 +Endometrial cancer 0.5431655869712547 1.11829144233267 0.2634425406471745 1.0 0.6895995916940746 11 P62993,P31751,P25054 3 +Chronic myeloid leukemia 0.4834895284465962 1.058459127908701 0.2898461750612711 1.0 0.7388647609169731 13 P62993,Q13363,P31751,P36507 4 +Proximal tubule bicarbonate reclamation 0.5896075361816169 0.987446182396861 0.323423953724238 1.0 0.7574929442488734 7 P00367 1 +Non small cell lung cancer 0.535044377935283 0.974853409246494 0.3296329796604524 1.0 0.7614310848535077 10 P62993,P31751,P36507 3 +Primary bile acid biosynthesis 0.4963396778916602 0.957366820883646 0.3383821390760011 1.0 0.7624306424750406 2 P51659 1 +Peroxisome 0.3850747982746874 0.9183883850392676 0.3584155693451771 1.0 0.7672025524927393 27 O15254,Q96HA9,Q13011,Q9BY49,Q9NR77,O75381 6 +Prostate cancer 0.4477628554146778 0.9114645749126178 0.3620506427493826 1.0 0.7672025524927393 14 P62993,P31751 2 +Fc epsilon ri signaling pathway 0.5381780224724472 0.9020164791833812 0.3670481138535781 1.0 0.7686419325404342 9 P62993,P31751 2 +Epithelial cell signaling in helicobacter pylori infection 0.3891889670808089 0.8343107564690612 0.4041058920140301 1.0 0.7697320773767002 22 Q9Y487 1 +Arachidonic acid metabolism 0.5929441802830392 0.8231458405540568 0.4104250633277244 1.0 0.7697320773767002 4 P09960 1 +Fatty acid metabolism 0.3700543677556702 0.7702754653704145 0.4411365068476325 1.0 0.7937714102155354 26 Q15067,O15254,P23786,Q9BWD1,Q16836,P51648 6 +T cell receptor signaling pathway 0.4007945489077829 0.7324912640805775 0.4638687728553154 1.0 0.7937714102155354 16 P62993,Q13153,P31751,P36507 4 +Natural killer cell mediated cytotoxicity 0.4189638076216538 0.7307662690880895 0.4649219299515854 1.0 0.7937714102155354 14 P01889,P62993,P36507 3 +Inositol phosphate metabolism 0.4750817500624705 0.6645439916733688 0.5063422026814768 1.0 0.8423262810962885 10 Q8NEB9,Q10713 2 +Type ii diabetes mellitus 0.5287681149522077 0.6476645610180373 0.5172019303232547 1.0 0.8446049871333883 6 O14654,P52789,P28482,P14618 4 +Bladder cancer 0.5312787527232923 0.5632774251682163 0.5732459878131033 1.0 0.9094974658681444 5 P36507 1 +Phosphatidylinositol signaling system 0.4675441058497831 0.5572193001272728 0.5773776047365187 1.0 0.9094974658681444 9 Q8NEB9,Q10713 2 +Toll like receptor signaling pathway 0.4130348719979855 0.5217063945646393 0.6018747717173856 1.0 0.917961314481146 12 P31751,Q13546 2 +Proteasome 0.3078069542150104 0.4618509701248027 0.6441881962964586 1.0 0.9290329555769976 36 P20618,P49721,P28072,Q99436,P48556,P28070 6 +Wnt signaling pathway 0.3369330877021638 0.4552579371660145 0.6489236834397736 1.0 0.9290329555769976 23 Q13363,Q8TAA9,Q13555,P25054 4 +Cell adhesion molecules cams 0.4675285899730695 0.4451801834061315 0.6561895463680492 1.0 0.9290329555769976 7 P01889,Q92896 2 +Melanoma 0.4523524952871023 0.4316594966668188 0.6659889093331135 1.0 0.9290329555769976 8 P31751,P36507 2 +Glioma 0.3941333354995597 0.4216398311074071 0.6732879284799589 1.0 0.9290329555769976 12 P62993,P31751,Q13555,P36507 4 +Thyroid cancer 0.4290052356136326 0.3831110936897385 0.7016373944498218 1.0 0.9329340364020328 9 Q16204 1 +Jak stat signaling pathway 0.4683067719198959 0.3347637141963303 0.7378033345708519 1.0 0.9329340364020328 5 P31751 1 +Basal transcription factors 0.465986503610553 0.3270590107369339 0.7436232530877938 1.0 0.9329340364020328 5 P29083 1 +Cysteine and methionine metabolism 0.3456464270021304 0.2986389304824453 0.7652155579477347 1.0 0.9329340364020328 14 Q13126,O43865 2 +Tryptophan metabolism 0.3416672050779621 0.2773216911653186 0.7815331053521741 1.0 0.9384894007331862 14 Q16836,P51648,Q9BWD1 3 +Other glycan degradation 0.4244265635770197 0.2490474019842962 0.8033241148111026 1.0 0.94073481866037 6 P06865,P04062,Q9BTY2 3 +Glycosaminoglycan degradation 0.4158079296303917 0.2215931079194474 0.8246306482056065 1.0 0.9531445154584284 6 P08236,P54802 2 +Apoptosis 0.3109613877548406 0.211049377370877 0.8328487414314276 1.0 0.9536511648972934 17 P31751,Q13546 2 +Tyrosine metabolism 0.4031032988111706 0.2072889965773388 0.8357841669886392 1.0 0.9536511648972934 7 P16930 1 +Progesterone mediated oocyte maturation 0.2895177965383952 0.1479152212684756 0.8824096755117494 1.0 0.9768587670407743 26 O43683,Q99640,P14635,P06493,Q9H1A4,P28482,Q9UJX4,P31751,Q13257,Q9UJX3,P04899 11 +Glycerolipid metabolism 0.3357526375764047 0.1464536632233953 0.8835632668177791 1.0 0.9768587670407743 12 Q9HCL2 1 +Retinol metabolism 0.3379714390333213 0.1140618306386978 0.9091887794365274 1.0 0.9868024557298894 3 P11766,Q6NUM9 2 +Leishmania infection 0.3770611945767625 0.0855811540115198 0.9317993804067176 1.0 1.0 5 P05556,P42224,Q16539,P28482 4 +Colorectal cancer 0.2991487276115138 0.072646077415956 0.9420877590851742 1.0 1.0 14 P31751 1 diff --git a/msigdb_kegg/selections.json b/msigdb_kegg/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..8cca5f83264054fba7b93c293114507351a41d99 --- /dev/null +++ b/msigdb_kegg/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["Abc transporters", "Acute myeloid leukemia", "Adherens junction", "Adipocytokine signaling pathway", "Alanine aspartate and glutamate metabolism", "Aldosterone regulated sodium reabsorption", "Allograft rejection", "Alpha linolenic acid metabolism", "Alzheimers disease", "Amino sugar and nucleotide sugar metabolism", "Aminoacyl trna biosynthesis", "Amyotrophic lateral sclerosis als", "Antigen processing and presentation", "Apoptosis", "Arachidonic acid metabolism", "Arginine and proline metabolism", "Arrhythmogenic right ventricular cardiomyopathy arvc", "Ascorbate and aldarate metabolism", "Autoimmune thyroid disease", "Axon guidance", "B cell receptor signaling pathway", "Basal cell carcinoma", "Basal transcription factors", "Base excision repair", "Beta alanine metabolism", "Biosynthesis of unsaturated fatty acids", "Bladder cancer", "Butanoate metabolism", "Calcium signaling pathway", "Cardiac muscle contraction", "Cell adhesion molecules cams", "Cell cycle", "Chemokine signaling pathway", "Chronic myeloid leukemia", "Citrate cycle tca cycle", "Colorectal cancer", "Cysteine and methionine metabolism", "Cytokine cytokine receptor interaction", "Cytosolic dna sensing pathway", "Dilated cardiomyopathy", "Dna replication", "Dorso ventral axis formation", "Drug metabolism cytochrome p450", "Drug metabolism other enzymes", "Ecm receptor interaction", "Endocytosis", "Endometrial cancer", "Epithelial cell signaling in helicobacter pylori infection", "Erbb signaling pathway", "Ether lipid metabolism", "Fatty acid metabolism", "Fc epsilon ri signaling pathway", "Fc gamma r mediated phagocytosis", "Focal adhesion", "Folate biosynthesis", "Fructose and mannose metabolism", "Galactose metabolism", "Gap junction", "Glioma", "Glutathione metabolism", "Glycerolipid metabolism", "Glycerophospholipid metabolism", "Glycine serine and threonine metabolism", "Glycolysis gluconeogenesis", "Glycosaminoglycan biosynthesis chondroitin sulfate", "Glycosaminoglycan biosynthesis heparan sulfate", "Glycosaminoglycan biosynthesis keratan sulfate", "Glycosaminoglycan degradation", "Glycosphingolipid biosynthesis ganglio series", "Glycosphingolipid biosynthesis globo series", "Glycosphingolipid biosynthesis lacto and neolacto series", "Glycosylphosphatidylinositol gpi anchor biosynthesis", "Glyoxylate and dicarboxylate metabolism", "Gnrh signaling pathway", "Graft versus host disease", "Hedgehog signaling pathway", "Hematopoietic cell lineage", "Histidine metabolism", "Homologous recombination", "Huntingtons disease", "Hypertrophic cardiomyopathy hcm", "Inositol phosphate metabolism", "Insulin signaling pathway", "Jak stat signaling pathway", "Leishmania infection", "Leukocyte transendothelial migration", "Limonene and pinene degradation", "Long term depression", "Long term potentiation", "Lysine degradation", "Lysosome", "Mapk signaling pathway", "Melanogenesis", "Melanoma", "Metabolism of xenobiotics by cytochrome p450", "Mismatch repair", "Mtor signaling pathway", "N glycan biosynthesis", "Natural killer cell mediated cytotoxicity", "Neurotrophin signaling pathway", "Nicotinate and nicotinamide metabolism", "Nitrogen metabolism", "Nod like receptor signaling pathway", "Non homologous end joining", "Non small cell lung cancer", "Notch signaling pathway", "Nucleotide excision repair", "O glycan biosynthesis", "Olfactory transduction", "One carbon pool by folate", "Oocyte meiosis", "Other glycan degradation", "Oxidative phosphorylation", "P53 signaling pathway", "Pancreatic cancer", "Pantothenate and coa biosynthesis", "Parkinsons disease", "Pathogenic escherichia coli infection", "Pathways in cancer", "Pentose and glucuronate interconversions", "Pentose phosphate pathway", "Peroxisome", "Phenylalanine metabolism", "Phosphatidylinositol signaling system", "Porphyrin and chlorophyll metabolism", "Ppar signaling pathway", "Primary bile acid biosynthesis", "Primary immunodeficiency", "Prion diseases", "Progesterone mediated oocyte maturation", "Propanoate metabolism", "Prostate cancer", "Proteasome", "Protein export", "Proximal tubule bicarbonate reclamation", "Purine metabolism", "Pyrimidine metabolism", "Pyruvate metabolism", "Regulation of actin cytoskeleton", "Regulation of autophagy", "Renal cell carcinoma", "Renin angiotensin system", "Retinol metabolism", "Riboflavin metabolism", "Ribosome", "Rig i like receptor signaling pathway", "Rna degradation", "Rna polymerase", "Selenoamino acid metabolism", "Small cell lung cancer", "Snare interactions in vesicular transport", "Sphingolipid metabolism", "Spliceosome", "Starch and sucrose metabolism", "Steroid biosynthesis", "Steroid hormone biosynthesis", "Sulfur metabolism", "Systemic lupus erythematosus", "T cell receptor signaling pathway", "Taste transduction", "Terpenoid backbone biosynthesis", "Tgf beta signaling pathway", "Thyroid cancer", "Tight junction", "Toll like receptor signaling pathway", "Tryptophan metabolism", "Type i diabetes mellitus", "Type ii diabetes mellitus", "Tyrosine metabolism", "Ubiquitin mediated proteolysis", "Valine leucine and isoleucine biosynthesis", "Valine leucine and isoleucine degradation", "Vascular smooth muscle contraction", "Vasopressin regulated water reabsorption", "Vegf signaling pathway", "Vibrio cholerae infection", "Viral myocarditis", "Wnt signaling pathway"], "available_proteins": ["AARS", "AARS2", "AASDHPPT", "AASS", "ABCB1", "ABCB10", "ABCB7", "ABCD3", "ACAA2", "ACACA", "ACACB", "ACADM", "ACADVL", "ACAT1", "ACAT2", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT7", "ACOT8", "ACOX1", "ACOX3", "ACP1", "ACP2", "ACP6", "ACSL1", "ACSL3", "ACSL4", "ACTN1", "ACTN2", "ACTN4", "ADA", "ADAR", "ADH5", "ADI1", "ADK", "ADSL", "ADSS", "AFDN", "AGK", "AGL", "AGPAT1", "AGPS", "AHCY", "AHCYL1", "AIFM1", "AK1", "AK2", "AK4", "AKR1A1", "AKR1B1", "AKT2", "ALDH18A1", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALG1", "ALYREF", "ANAPC1", "ANAPC4", "ANAPC5", "ANAPC7", "AP1B1", "AP1G1", "AP1M1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "APC", "APEX1", "APP", "APPL1", "APRT", "AQR", "ARFGAP1", "ARHGDIA", "ARHGEF1", "ARHGEF2", "ARPC1A", "ARPC2", "ARPC3", "ARPC4", "ARPC5", "ASAH1", "ASNA1", "ASNS", "ATG7", "ATIC", "ATP1A1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5L", "ATP5O", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1D", "ATP6V1E1", "ATP6V1H", "AURKA", "B3GALT6", "B4GAT1", "BAIAP2", "BCAS2", "BDH2", "BIRC6", "BLVRA", "BLVRB", "BNIP1", "BPNT1", "BUB1", "BUB1B", "BUB3", "BUD31", "CACYBP", "CAD", "CALD1", "CALM3", "CALR", "CAMK2G", "CANX", "CAPN1", "CARS", "CARS2", "CASK", "CASP3", "CASP6", "CASP7", "CASP8", "CBR1", "CCDC6", "CCNB1", "CD47", "CDC16", "CDC23", "CDC27", "CDC40", "CDC42", "CDC45", "CDC5L", "CDIPT", "CDK1", "CDK2", "CDK4", "CDK6", "CDS2", "CETN2", "CFL1", "CFL2", "CHEK2", "CHERP", "CHKA", "CHMP2B", "CHMP5", "CHMP6", "CHORDC1", "CHST14", "CKB", "CKMT1A*", "CLN5", "CLTA", "CLTC", "CMPK1", "CNOT1", "CNOT7", "CNOT9", "COASY", "COMT", "COX15", "COX2", "COX4I1", "COX5A", "COX5B", "COX6C", "COX7A2", "COX7C", "CPOX", "CPT1A", "CPT2", "CRKL", "CRNKL1", "CS", "CSK", "CSNK1A1", "CSNK2A2", "CSNK2B", "CTBP1", "CTBP2", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTPS2", "CTSA", "CTSC", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4A", "CUL4B", "CUL5", "CYB5R3", "CYC1", "CYFIP1", "CYP51A1", "DAD1", "DARS", "DARS2", "DCP1A", "DCPS", "DCTD", "DCTN1", "DCTN2", "DCTN4", "DCTN6", "DCXR", "DDB1", "DDOST", "DDX23", "DDX39B", "DDX3X", "DDX42", "DDX46", "DDX5", "DDX6", "DERL1", "DFFA", "DHCR24", "DHCR7", "DHFR", "DHX15", "DHX16", "DHX38", "DHX8", "DIAPH1", "DIAPH3", "DIS3", "DLAT", "DLD", "DLST", "DNM1L", "DNM2", "DNMT1", "DOLPP1", "DPYSL2", "DSG2", "DSP", "DTYMK", "DUSP3", "DUSP9", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNLL1", "DYNLL2", "EARS2", "EBP", "ECH1", "ECHS1", "ECI1", "ECI2", "ECSIT", "EDC3", "EDC4", "EEA1", "EFTUD2", "EHD1", "EHD4", "EIF4A3", "EIF4B", "EIF4E", "EIF4G1", "EIF4G2", "EIF4G3", "ELOB", "ELOC", "EMD", "ENAH", "ENDOD1", "ENO1", "EPB41", "EPB41L2", "EPB41L3", "EPHX1", "EPHX2", "EPRS", "EPS15", "ERCC2", "ERCC3", "ERO1A", "EXO1", "EXOC4", "EXOC7", "EXOSC10", "EXOSC3", "EXOSC4", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC8", "EZR", "F11R", "FABP5", "FADS2", "FAH", "FAR1", "FARSA", "FARSB", "FASN", "FAU", "FDFT1", "FDPS", "FECH", "FEN1", "FH", "FLAD1", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FUCA1", "FUCA2", "G6PD", "GAA", "GABARAPL2", "GALK1", "GALNT2", "GALNT7", "GANAB", "GAPDH", "GARS", "GART", "GBA", "GBE1", "GCAT", "GCDH", "GCLM", "GFPT1", "GGA1", "GGCT", "GGH", "GLA", "GLB1", "GLDC", "GLG1", "GLO1", "GLS", "GLUD1", "GM2A", "GMDS", "GMPPA", "GMPPB", "GMPS", "GNA13", "GNAI1", "GNAI2", "GNAI3", "GNPDA1", "GNS", "GOT1", "GOT2", "GPAM", "GPD2", "GPI", "GPT2", "GRB2", "GRHPR", "GSK3A", "GSK3B", "GSR", "GSS", "GSTK1", "GSTM3", "GSTO1", "GSTZ1", "GTF2B", "GTF2E1", "GTF2F1", "GTF2F2", "GTF2I", "GUSB", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HADH", "HADHA", "HADHB", "HCCS", "HDAC2", "HEXA", "HEXB", "HGS", "HIBADH", "HIBCH", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HMBS", "HMGB1", "HMGCL", "HMGCS1", "HMOX1", "HMOX2", "HNRNPA1", "HNRNPA3", "HNRNPC", "HNRNPK", "HNRNPM", "HNRNPU", "HPRT1", "HS2ST1", "HSD17B10", "HSD17B12", "HSD17B4", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA1B", "HSPA2", "HSPA4", "HSPA8", "HSPA9", "HSPB1", "HSPD1", "HTT", "HUWE1", "IARS", "IARS2", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDI1", "IGF2BP1", "IGF2R", "ILK", "IMPDH1", "IMPDH2", "IQGAP1", "IRS4", "ISYNA1", "ITCH", "ITGB1", "ITPA", "IVD", "JUP", "KARS", "KDELR1", "KDSR", "L2HGDH", "LAMP1", "LAMP2", "LAP3", "LARS", "LARS2", "LDHA", "LDHB", "LDLR", "LGMN", "LIG1", "LIG3", "LIPA", "LLGL1", "LMNA", "LNPEP", "LPCAT1", "LSM6", "LSM7", "LSM8", "LSS", "LTA4H", "LYPLA1", "M6PR", "MAD1L1", "MAD2L1", "MAP2K1", "MAP2K2", "MAP2K3", "MAPK1", "MAPK14", "MARCKS", "MARS", "MARS2", "MAT2A", "MAT2B", "MAVS", "MBOAT7", "MCCC1", "MCCC2", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MDH1", "MDH2", "ME2", "MGST2", "MGST3", "MID1", "MIF", "MINPP1", "MMAB", "MOGS", "MPI", "MPST", "MRE11", "MSH2", "MSH3", "MSH6", "MSMO1", "MSN", "MTAP", "MTCH1", "MTHFD1", "MTHFD1L", "MTHFD2", "MTOR", "MTR", "MUT", "MYH10", "MYH14", "MYH9", "MYL6", "NAE1", "NAGK", "NAGLU", "NAMPT", "NANS", "NARS", "NBN", "NCBP1", "NCBP2", "NCKAP1", "NCL", "NCSTN", "NDUFA10", "NDUFA11", "NDUFA2", "NDUFA4", "NDUFA5", "NDUFA7", "NDUFA8", "NDUFA9", "NDUFB10", "NDUFB3", "NDUFB4", "NDUFB5", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS7", "NDUFS8", "NDUFV1", "NDUFV2", "NEFL", "NEFM", "NFKB1", "NLN", "NME1", "NME2", "NNT", "NPC1", "NSD2", "NSDHL", "NSF", "NT5C2", "NUDT5", "NUDT9", "OAT", "OCLN", "OGDH", "OXA1L", "P4HA1", "P4HA2", "PAFAH1B1", "PAFAH1B3", "PAICS", "PAK1", "PAK2", "PANK4", "PAPSS1", "PARK7", "PARN", "PARP1", "PARP2", "PC", "PCBP1", "PCCA", "PCCB", "PCK2", "PCNA", "PDCD6", "PDCD6IP", "PDE6D", "PDHA1", "PDHB", "PDIA3", "PDIA4", "PECR", "PEX11G", "PEX14", "PEX19", "PEX5", "PFAS", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGP", "PHF5A", "PHGDH", "PI4KB", "PIGK", "PIGS", 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a/msigdb_reactome/df_merge.tsv b/msigdb_reactome/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..a56f498ea6185ec82d5e6da5f37e6aeab8ffabfa --- /dev/null +++ b/msigdb_reactome/df_merge.tsv @@ -0,0 +1,19 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Protein localization 28 69 4.104626891997333 4.049679412054808e-05 25.97087378640777 74.18203883495146 1.5594110758345356 0.2555609300308859 10.717199959161563 6.26233677332747 2.0947329132902324 0.3569924888492793 8.555196416732768e-11 5.608080016760057e-05 9.1412351535337e-06 1.8180199045584748e-10 1.6898880549305213e-13 +Metabolism of lipids 53 157 3.764680285769488 0.0001667623142524 47.21601941747573 182.9902912621359 0.7669400545274999 0.4573741022352977 16.76057659641467 20.451455734561765 1.5920609507025254 0.4091924181498379 3.730181662238224e-08 0.0006075160134359 2.770558605410633e-05 1.8156661492595415e-08 8.031918301162305e-10 +Mitochondrial protein import 12 33 3.2868503559485487 0.0010131465668081 13.468446601941748 34.5873786407767 1.6025718162972953 0.1874419874946837 6.078090089851624 2.2108812815475147 1.8878681708577505 0.2901223460226844 1.0563307949600438e-05 8.566885380985011e-06 1.4829761681112925e-06 1.0845222485789932e-05 6.252354807206027e-07 +Phospholipid metabolism 13 37 3.2755915278148864 0.0010544094184028 12.859223300970871 45.932038834951456 1.017004520648936 0.3949296504793965 6.241466981115118 7.362344677079641 1.3242274243570669 0.3709328103546776 0.1563873033776617 0.5310682828592934 0.0177954183640811 0.1777347207096481 0.0090876182913912 +Metabolism of steroids 19 44 2.965835575761485 0.0030186182640021 11.16019417475728 45.26699029126213 0.7621248609364072 0.3994790342082778 4.702670999060317 5.049423467032678 1.2014135082145578 0.3371477938402821 2.568958729332959e-06 0.0131788445501069 0.0004815815479713 2.9722521042999303e-09 3.268688183990494e-09 +Cholesterol biosynthesis 9 15 2.9478904646694084 0.0031995040963972 5.878640776699029 16.75 1.3996798653689082 0.2350718901934974 2.503362805703168 1.8986773628384943 1.0886216368414 0.270950573691616 1.5989970749316036e-07 0.0001966568602221 7.654983120717976e-05 8.453932366290168e-11 4.63717245406321e-09 +Transport of small molecules 37 134 2.831893167537524 0.0046273306176836 41.730582524271846 151.96601941747574 1.4265613612661356 0.380396759556163 14.87709311863932 12.598305121005488 1.746958952072276 0.4128488770716938 0.0001784155387189 0.0089635558358088 6.790561936078023e-05 0.0008349663943463 1.56229531619534e-05 +Glycerophospholipid biosynthesis 10 27 2.7836735745868597 0.0053747095632976 9.439320388349516 29.58009708737864 1.1800609247564997 0.3081196451067344 4.809346434845489 4.094857299253986 1.3402414818469337 0.3224557628717913 0.0719912230204467 1.0 0.009674915769008 0.0574018644712506 0.002942030922613 +Signaling by insulin receptor 4 14 2.495646233956556 0.012572792060822 3.91504854368932 15.699029126213592 0.5754214954087689 0.534682491573688 2.331728544953775 1.4948776711085254 0.7798073838753424 0.3154925742571588 0.0089185628538315 0.0012844156650938 0.0009182879541791 0.0230341265569123 0.0664883963333954 +Sphingolipid metabolism 10 24 2.4814967756614537 0.0130831893997231 11.00242718446602 26.135922330097088 1.1708540815039898 0.1757583754913391 4.192861933829232 2.1968580551223003 2.1941615995620167 0.2567064655985949 0.0008954100447801 0.0356328568827733 0.1215022402141297 0.0001156252433491 0.0001751164615691 +Sphingolipid de novo biosynthesis 6 10 2.438142344302244 0.0147629594657265 4.08252427184466 10.614077669902912 1.3205451179619188 0.2079933246203462 1.939118365602947 1.3614298144224892 1.289169434780902 0.261809046515659 0.001782236196207 0.0084566179175882 0.031964215627013 0.0005910649168726 0.0003831746340893 +Rac2 gtpase cycle 8 30 2.295779181476488 0.021688510370851 8.905339805825243 34.74757281553398 0.8419178475366841 0.4471774138928159 4.131135699306596 3.707034631516275 0.9898490308362274 0.3561406142763811 0.0160645192136559 0.0576595399457578 0.0439828576930944 0.0136037852653257 0.0166834942199113 +Phase i functionalization of compounds 3 14 2.215683505244209 0.0267131853484499 3.5364077669902914 14.184466019417476 1.0829555250605305 0.2802752482018614 1.63283502003666 1.0657744603346575 1.0337417132355466 0.2758879448139676 0.0053575023696682 0.01497108596825 0.006299868694297 0.0142235096743441 0.1203149601397993 +Insertion of tail anchored proteins into the endoplasmic reticulum membrane 6 11 2.208622490642306 0.0272009096665533 4.016990291262136 10.99757281553398 1.1239772251284714 0.2752182956921286 1.9514004604865949 1.181365809872934 1.0815649178051203 0.2865915409883788 0.0003353441275824 0.0875404472016038 0.1693528922958147 7.054294597105141e-05 1.8924379158190217e-05 +Slc mediated transmembrane transport 6 18 2.1875345029464706 0.0287035273001989 8.672330097087379 21.910194174757283 1.4735742044813558 0.239038892478899 4.348519601656105 3.146764860695784 1.3934177975338422 0.3068823132077037 0.1128929543901479 0.3867386931517215 0.0166697170946546 0.2290317051514284 0.2219073979752139 +Mitochondrial calcium ion transport 6 15 2.1628610538691504 0.0305518680342675 6.502427184466019 16.12135922330097 1.0650233237312683 0.2089377868120644 3.410790121717641 1.246287729205551 1.626144580445205 0.28031724173526 0.0554017251753425 0.0044823878286489 0.0173819675279631 0.090818300458346 4.010191317578068e-05 +Peroxisomal lipid metabolism 4 10 2.088763785449084 0.0367289918462987 4.140776699029126 12.12378640776699 0.317537357574623 0.4492199547416179 2.323285959404439 1.85171587521782 1.0645190766414347 0.3038959358219866 0.0008560924211317 1.0 0.208984012191681 0.0024379570615939 0.0053032680205866 +Class i peroxisomal membrane protein import 6 10 2.041603622085277 0.0411908657295243 4.300970873786408 9.604368932038836 1.1426576411245968 0.2560233101944223 2.515331441636984 1.9424437465598188 1.2133199793435778 0.2911424942178205 0.0046672984761978 1.0 1.0 0.0102137155300364 0.0002049367226 diff --git a/msigdb_reactome/metrics.json b/msigdb_reactome/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..961e6ccc409f9c1af66f4fe4c3ec78aaa612ffc5 --- /dev/null +++ b/msigdb_reactome/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2734, + "annotations_size": 1359, + "title": "Average number of proteins per term", + "value": 17.910228108903606 +} \ No newline at end of file diff --git a/msigdb_reactome/paths.json b/msigdb_reactome/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..dfdca08ce423fef5532ab6fe5668b09409fdd2f7 --- /dev/null +++ b/msigdb_reactome/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/msigdb_reactome/fragment/C166/C166_val_log2fc"} \ No newline at end of file diff --git a/msigdb_reactome/result.tsv b/msigdb_reactome/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..837a860483a1cba571380efa0218baf339bffcdc --- /dev/null +++ b/msigdb_reactome/result.tsv @@ -0,0 +1,333 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Protein localization 0.6048583184468217 4.104626891997333 4.0496794120548074e-05 0.0535491687169231 0.0024333408700819 69 Q99595,O60830,P21796,Q9NS69,P46379,Q9BY49,Q9NR77,Q13505,P51648,Q15067,P09601,Q10713,P05067,O75431,Q13190,Q8NBU5,O15254,Q8N4H5,O43615,O14734,Q5JRX3,O14925,O96008,Q13011,P62072,O43681,O75381,P50402 28 +Metabolism of lipids 0.465973371923784 3.764680285769488 0.0001667623142524 0.2027993568165034 0.0032925140530969 157 P09960,Q8NEB9,P27544,Q16850,P37268,P50897,Q8TBX8,P23786,Q9BY49,Q8IV08,O95772,P51648,Q9P035,Q96G23,P35790,Q15392,Q15067,O95470,Q06136,Q15165,Q10713,Q9BWD1,Q9NPH0,P38435,Q14534,Q15125,Q9NQZ5,Q9HCL2,Q96N66,O15254,P43304,P48651,O95487,P22059,Q53GQ0,P40939,P04062,O14734,Q9BZF3,Q15800,Q8NCC3,Q9UBM7,Q14739,Q9NZJ7,O43772,P48449,O15269,P07602,O43681,O00767,Q16836,Q8N2A8,Q9H7Z7 53 +Mitochondrial protein import 0.6410738471681645 3.2868503559485487 0.0010131465668081 0.7478078896825082 0.0122934480740385 33 Q99595,O60830,P21796,Q5JRX3,O14925,Q9NS69,Q8N4H5,Q10713,P62072,Q13505,O43615,O75431 12 +Phospholipid metabolism 0.6159162881215805 3.2755915278148864 0.0010544094184028 0.7615744996722968 0.0126133975730711 37 Q8NEB9,P35790,Q9NQZ5,Q9HCL2,Q96N66,P40939,Q8NCC3,P43304,P48651,Q10713,Q8IV08,Q9NPH0,Q8N2A8 13 +Antigen activates b cell receptor bcr leading to generation of second messengers 0.9008052708638384 2.9826931864090955 0.0028572426344999 0.9795250001360798 0.026414916600581 2 O43865 1 +Metabolism of steroids 0.5514572062195897 2.965835575761485 0.0030186182640021 0.983567699712329 0.0277182582485065 44 Q16850,P37268,O95772,Q15392,Q9BWD1,P38435,Q14534,Q15125,Q9HCL2,O95487,P22059,Q53GQ0,P04062,Q9BZF3,Q15800,Q9UBM7,Q14739,P48449,O00767 19 +Cholesterol biosynthesis 0.7703609056051466 2.9478904646694084 0.0031995040963972 0.9871588043164494 0.0287955368675752 15 Q15125,Q15800,Q16850,Q15392,P37268,Q14739,P48449,Q9BWD1,Q14534 9 +Transport of small molecules 0.4177494297435886 2.831893167537524 0.0046273306176836 0.9981694465602962 0.0381123776329213 134 Q9Y277,P21796,O75027,O15118,P45880,P51790,Q8IYU8,Q9Y487,P16615,Q13546,Q93050,Q8WTV0,Q9BUN8,P11166,P28288,Q70HW3,O43242,Q99436,P09601,Q10713,Q8WWC4,O95202,P49721,Q99797,Q9HD20,P12236,P30825,Q9UBX3,Q8TB61,P28070,P30519,P27105,P08183,Q13555,P20618,P28072,P48556 37 +Synthesis secretion and deacylation of ghrelin 0.8594436310395364 2.7924919227184044 0.0052303773423791 0.9991966634849472 0.0418122518134901 2 P67812 1 +Synthesis secretion and inactivation of glucose dependent insulinotropic polypeptide gip 0.8594436310395364 2.7924919227184044 0.0052303773423791 0.9991966634849472 0.0418122518134901 2 P67812 1 +Glycerophospholipid biosynthesis 0.620428874433675 2.7836735745868593 0.0053747095632976 0.999340434961736 0.0427147970556814 27 Q9NQZ5,Q9HCL2,P35790,Q96N66,P40939,Q8NCC3,P43304,P48651,Q8IV08,Q9NPH0 10 +Alpha oxidation of phytanate 0.9423914339115302 2.6869659483988073 0.007210430297974 0.999946427406082 0.0550504200839706 3 Q9BY49 1 +Tryptophan catabolism 0.8268667642752602 2.639663997021424 0.0082988260271839 0.9999879345265336 0.0599899179305474 2 Q6YP21 1 +Abc transporters in lipid homeostasis 0.8052708638360182 2.5368570101101104 0.0111852629758997 0.9999997702844406 0.0763857908756167 2 P28288 1 +Irs mediated signalling 0.9011351153423656 2.5123067092324116 0.0119944792296295 0.9999999244932716 0.0806955310547852 3 Q8NEB9,P31751 2 +Signaling by insulin receptor 0.7090703150078984 2.495646233956556 0.012572792060822 0.9999999659264812 0.0827963442994279 14 Q93050,Q8NEB9,Q9Y487,P31751 4 +Sphingolipid metabolism 0.5965303814965031 2.4814967756614537 0.0130831893997231 0.9999999831242614 0.0846669256867801 24 Q96G23,P27544,O95470,Q06136,Q9NZJ7,P22059,P07602,O43681,P04062,P51648 10 +Sphingolipid de novo biosynthesis 0.8232515281514575 2.4381423443022436 0.0147629594657265 0.9999999983333152 0.0928836199718631 10 Q96G23,P27544,O95470,Q06136,P22059,P51648 6 +Coenzyme a biosynthesis 0.7730600292825802 2.381285522116564 0.0172523340036627 0.9999999999464564 0.1048818649290538 2 Q13057 1 +Rac2 gtpase cycle 0.5366165755672829 2.2957791814764876 0.021688510370851 0.9999999999998856 0.1228111899749441 30 Q14739,P42167,O15173,Q8TAA9,Q68EM7,Q13505,Q86XL3,P50402 8 +Ptk6 regulates proteins involved in rna processing 0.8476748443793484 2.2807776246311473 0.0225616090716429 0.999999999999966 0.1261778877710402 3 O75525,Q07666 2 +Activation of smo 0.7481698389458309 2.2592411853053154 0.0238683862100845 0.9999999999999944 0.1302696259417869 2 P48729 1 +The phototransduction cascade 0.841759817266406 2.254799626712109 0.0241459087304607 0.9999999999999962 0.130319602648539 3 P53582 1 +Synthesis of pg 0.8353262439263929 2.2264631879800287 0.0259831720885701 0.9999999999999996 0.1363364126191769 3 Q8IV08 1 +Phase i functionalization of compounds 0.6600366030023664 2.215683505244209 0.0267131853484499 1.0 0.1386630000571017 14 P07099,Q16850,O43169 3 +Insertion of tail anchored proteins into the endoplasmic reticulum membrane 0.747707851318581 2.208622490642306 0.0272009096665533 1.0 0.1405552708625321 11 P46379,P09601,P05067,O43681,Q13190,P51648 6 +Slc mediated transmembrane transport 0.5967384160423596 2.1875345029464706 0.0287035273001989 1.0 0.146249284006743 18 P11166,Q70HW3,P12236,P30825,Q9UBX3,Q8TB61 6 +Mitochondrial calcium ion transport 0.6342013000488845 2.1628610538691504 0.0305518680342675 1.0 0.1532102902530244 15 O95202,Q9Y277,P21796,P45880,Q10713,Q8WWC4 6 +Amino acid transport across the plasma membrane 0.8146333812676808 2.1347535644045625 0.0327811451277844 1.0 0.1596759004611434 3 P30825 1 +Peroxisomal lipid metabolism 0.7510911625428284 2.0887637854490837 0.0367289918462987 1.0 0.1727152246336331 10 O15254,Q9BY49,Q15067,P51648 4 +Hs gag degradation 0.7939824964895521 2.0423773423174536 0.0411141154895755 1.0 0.1835356935292577 3 P08236 1 +Class i peroxisomal membrane protein import 0.7415587009098715 2.041603622085277 0.0411908657295243 1.0 0.1835356935292577 10 Q8TB36,P28288,Q8NBU5,Q9NR77,O75381,P51648 6 +Insulin receptor signalling cascade 0.8832131869922202 2.040193376108253 0.0413310692364172 1.0 0.1835585721970296 4 Q8NEB9,P31751 2 +Nuclear receptor transcription pathway 0.6994875549048327 2.0160098209742903 0.0437989488424126 1.0 0.192630328404009 2 Q9UHY1 1 +Signaling by type 1 insulin like growth factor 1 receptor igf1r 0.8767302084698574 2.0138837742782583 0.0440217374665148 1.0 0.1929856168290118 4 Q8NEB9,P31751 2 +Pre notch processing in golgi 0.7851200779694452 2.002477757229214 0.0452333729916434 1.0 0.1976596588284354 3 P16615 1 +Free fatty acids regulate insulin secretion 0.6921669106881475 1.9789316862878772 0.0478236981520412 1.0 0.2043786345554215 2 O60488 1 +G alpha i signalling events 0.5547579708367973 1.946022457896193 0.0516520419884567 1.0 0.2179972828022134 19 Q9NZJ7,Q9NRV9,P05067,O43865,P07602 5 +Protein protein interactions at synapses 0.6305765935096102 1.9369214785782072 0.0527549424888098 1.0 0.2219627456417727 13 O14936,O95197,Q14168 3 +Mitophagy 0.6614111153265095 1.929852969106642 0.0536250581798012 1.0 0.2237940402305804 12 P21796,Q9NS69 2 +Transport of inorganic cations anions and amino acids oligopeptides 0.7937644149574044 1.9296191646520473 0.0536540424452358 1.0 0.2237940402305804 7 P30825,Q70HW3 2 +Cargo concentration in the er 0.6100360125928221 1.9208605099984384 0.0547492954572168 1.0 0.2242393469521845 14 Q96PC5,P53634,Q13190,O95487 4 +Peptide ligand binding receptors 0.7836553951612338 1.884279888765868 0.0595271262916563 1.0 0.2358523750156297 7 P07602,Q9NZJ7,P42892,P05067 4 +Class a 1 rhodopsin like receptors 0.7836553951612338 1.884279888765868 0.0595271262916563 1.0 0.2358523750156297 7 P07602,Q9NZJ7,P42892,P05067 4 +Autophagy 0.4367799914523851 1.8797500405761576 0.0601421521806111 1.0 0.2375964674809609 44 P21796,Q8NEB9,Q9NS69,Q8N4H5 4 +Ion channel transport 0.5186778285323768 1.8636776720123212 0.0623669827636463 1.0 0.2428559586699009 23 Q93050,Q9C0H2,Q9HD20,P51790,P27105,Q9Y487,P16615,Q13555,Q13546 9 +Heparan sulfate heparin hs gag metabolism 0.8400800482605553 1.8564609718988536 0.0633878809804415 1.0 0.244727642762557 5 Q96L58,Q7LGA3,P08236 3 +Gpcr ligand binding 0.7520186553589865 1.8494841492768943 0.0643879345110085 1.0 0.2478844277633445 8 P07602,Q9NZJ7,P42892,P05067 4 +Akt phosphorylates targets in the cytosol 0.7490791987615034 1.838696703654632 0.0659598085335861 1.0 0.2525052952032215 3 P31751 1 +Maturation of sars cov 1 nucleoprotein 0.6625183016105468 1.8275024378965607 0.0676242599907277 1.0 0.2574268048386526 2 P49840 1 +Cargo trafficking to the periciliary membrane 0.5249242413726867 1.778284558284993 0.0753571311766361 1.0 0.2782889708398056 20 A6NIH7,O43924,P61006 3 +Flt3 signaling 0.7348887222049094 1.7735744111290932 0.0761335734524741 1.0 0.2796365576267903 3 P31751 1 +Glycosaminoglycan metabolism 0.6015986573288451 1.7684824302097424 0.0769802869100162 1.0 0.2797224863922782 13 Q8NCH0,Q7LGA3,Q96L58,Q8TB61,P08236 5 +Activation of the ap 1 family of transcription factors 0.650805270863837 1.767149974070075 0.077203115090187 1.0 0.2797840890868379 2 P28482 1 +Transport of bile salts and organic acids metal ions and amine compounds 0.6471449487554949 1.748232309618072 0.0804238090168247 1.0 0.2861150692509552 2 P53985 1 +Proton coupled monocarboxylate transport 0.6471449487554949 1.748232309618072 0.0804238090168247 1.0 0.2861150692509552 2 P53985 1 +Iron uptake and transport 0.5306326483302235 1.7419665789990186 0.0815142924980214 1.0 0.2886978723912847 18 Q93050,Q9Y487,P30519 3 +Heme degradation 0.8102564102564109 1.740409580455037 0.0817871244717305 1.0 0.2886978723912847 4 P30519,P09601,P30043 3 +Pink1 prkn mediated mitophagy 0.7052077612004456 1.739300058798004 0.0819819969947057 1.0 0.2886978723912847 9 P21796,O96008,Q9NS69,Q8N4H5 4 +Metabolism of porphyrins 0.6803363541325886 1.7333377178417586 0.0830356605299358 1.0 0.2894891340060915 10 P36551,P09601,P30043,Q7KZN9,P30519 5 +G2 m dna replication checkpoint 0.726107652874405 1.7331086909870532 0.0830763519222776 1.0 0.2894891340060915 3 P14635,Q99640 2 +E2f enabled inhibition of pre replication complex formation 0.7261076528744048 1.733108690987052 0.0830763519222779 1.0 0.2894891340060915 3 Q9Y619,P14635 2 +Cristae formation 0.532349363957589 1.7202791825241297 0.0853817056534103 1.0 0.2960044336300627 17 Q13505,O75431 2 +Respiratory electron transport 0.4113519619100199 1.690798382062248 0.0908753163169271 1.0 0.3073427949402262 48 Q86Y39,P13073,O95168,P21912,O14949,O75306,Q7L592,O96000,O43676,Q9UDW1 10 +Regulation of insulin like growth factor igf transport and uptake by insulin like growth factor binding proteins igfbps 0.5710616498285854 1.6846963761148712 0.0920471660493844 1.0 0.3104022299283213 14 O43852,O76024,Q02818,P05067,Q07065 5 +Bile acid and bile salt metabolism 0.759150709978691 1.6725743599658471 0.0944111179278914 1.0 0.3151784684311174 6 P22059,Q9BZF3 2 +Synthesis of bile acids and bile salts 0.759150709978691 1.6725743599658471 0.0944111179278914 1.0 0.3151784684311174 6 P22059,Q9BZF3 2 +Pi metabolism 0.6422967583120042 1.6583048152792672 0.0972559575931426 1.0 0.321591835863451 11 Q8TBX8,Q8NEB9,Q10713 3 +Complex i biogenesis 0.4782388523364324 1.658292420731784 0.097258458086739 1.0 0.321591835863451 26 Q86Y39,Q9H845,Q9NX14,O95168,O75306,Q7L592,O96000,Q9Y6M9,O43676 9 +Respiratory electron transport atp synthesis by chemiosmotic coupling and heat production by uncoupling proteins 0.4025045384934227 1.656814345609393 0.0975570157600738 1.0 0.3217960786843211 56 Q86Y39,P13073,O95168,O75964,P21912,O14949,O75306,Q7L592,O96000,O43676,Q9UDW1 11 +Transferrin endocytosis and recycling 0.6395395062511522 1.6435236902087 0.1002746279461765 1.0 0.3286301852717095 11 Q9Y487 1 +Vitamin d calciferol metabolism 0.7067061986954475 1.6432758493559867 0.100325872741966 1.0 0.3286301852717095 3 P04062 1 +Biological oxidations 0.422371929272389 1.637214325884025 0.1015856947253945 1.0 0.3286301852717095 40 Q16850,P21964,Q8TB61,O43169,Q9NUJ1,P07099 6 +Regulation of ifng signaling 0.6255490483162544 1.6360996641454373 0.1018187304902444 1.0 0.3286301852717095 2 P42224 1 +Regulation of ifna signaling 0.6255490483162544 1.6360996641454373 0.1018187304902444 1.0 0.3286301852717095 2 P42224 1 +Ras processing 0.7831630245728436 1.6190423020260554 0.1054381617089164 1.0 0.3324604681262584 5 O60725,O43924 2 +Synthesis of pa 0.7183188334563091 1.586870422067454 0.1125419951215143 1.0 0.3452473394359773 7 Q9NPH0,P43304,Q9HCL2,Q8N2A8 4 +Synaptic adhesion like molecules 0.7729763160782732 1.5761091271422416 0.1150006559685536 1.0 0.3512042504747516 5 O95197 1 +Beta oxidation of butanoyl coa to acetyl coa 0.6874314006003686 1.5535055004675764 0.1203024162084598 1.0 0.3633132969495486 3 Q16836 1 +Vitamin c ascorbate metabolism 0.6851718371259807 1.542951272761732 0.122842599074084 1.0 0.3692177336141797 3 P11166 1 +Insulin receptor recycling 0.6421785456754474 1.536881700646455 0.1243222814741562 1.0 0.3721453315492914 10 Q9Y487 1 +Activation of gene expression by srebf srebp 0.5171608556701096 1.5185152529800563 0.1288845572845192 1.0 0.378168457565718 16 Q9HCL2,Q16850,P37268,P48449,O00767,Q14534 6 +Fceri mediated ca 2 mobilization 0.6797059868614062 1.5173966328141355 0.1291665735654619 1.0 0.378168457565718 3 O43865 1 +Ros and rns production in phagocytes 0.6593132844409147 1.5120998345199346 0.1305084669597658 1.0 0.378168457565718 9 Q9Y487 1 +Role of phospholipids in phagocytosis 0.6765676620970873 1.502709181462298 0.132914054049035 1.0 0.3823240654280851 3 O43865 1 +Rhog gtpase cycle 0.4367460036745821 1.501913650943831 0.1331194106727868 1.0 0.3823240654280851 31 O95202,Q14739,P42167,O15173,Q8TAA9,Q13190,Q86XL3 7 +Visual phototransduction 0.7200265202472156 1.4987532485136887 0.1339376571332098 1.0 0.3832026864084887 6 P53582 1 +Synthesis of pips at the golgi membrane 0.7529969394597467 1.4915772729407288 0.1358099998576674 1.0 0.3850213663419168 5 Q8NEB9,Q10713 2 +Beta oxidation of pristanoyl coa 0.7471169063094454 1.4752496621322944 0.1401454342622821 1.0 0.3925789442630636 4 O15254 1 +Suppression of apoptosis 0.7460747786228751 1.4708389072504962 0.1413346876597589 1.0 0.3935939355115009 4 P14373,P23246 2 +Regulation of cholesterol biosynthesis by srebp srebf 0.470182543731001 1.4591819502474384 0.1445150353535116 1.0 0.3999917169967867 22 Q9HCL2,Q16850,P37268,Q9UBM7,O95487,O75845,P48449,O00767,Q14534 9 +Ub specific processing proteases 0.373104802572309 1.4557685847448238 0.1454566029573549 1.0 0.400964550545731 64 Q9Y277,P20618,P49721,P21796,P28072,Q99436,P45880,Q96K76,P28070,Q13546 10 +Selective autophagy 0.4307374584455318 1.4488741371878673 0.1473727349411817 1.0 0.4037894088408588 31 P21796,O96008,Q9NS69,Q13409,Q8N4H5,P50542,Q8IWA4,P08670 8 +Synthesis of very long chain fatty acyl coas 0.7048346150649677 1.4307710053506175 0.1524958554857822 1.0 0.4111941817563057 6 Q53GQ0,O60488,Q9P035 3 +Formyl peptide receptors bind formyl peptides and many other ligands 0.6609021771193158 1.4292508907605592 0.1529321354213513 1.0 0.411554004034884 3 P05067 1 +Signaling by erbb4 0.7020171221723623 1.418138444833697 0.1561503489869471 1.0 0.4154043983262641 6 P62993 1 +Rhoa gtpase cycle 0.3919330815890891 1.3763008226950146 0.1687285183212992 1.0 0.4392759701123479 42 P28288,Q14739,P42167,P41440,Q8TAA9,O15173,P51572,P30519,Q13190 9 +Assembly and cell surface presentation of nmda receptors 0.5872786365345537 1.360363118238175 0.1737150436510757 1.0 0.4496737987082131 11 O14936,Q14168,Q13555 3 +Mucopolysaccharidoses 0.7184671227139772 1.353709471680917 0.1758290851243018 1.0 0.4534188362123837 4 P08236 1 +Signaling by the b cell receptor bcr 0.3868547514861172 1.3462837388235815 0.1782110280288842 1.0 0.4560994107179918 43 P20618,P49721,P28072,Q99436,P62993,P62942,P48556,P28070,O43865 9 +Peroxisomal protein import 0.4762569246173756 1.333372263264085 0.1824096699814521 1.0 0.4616301329642632 17 O15254,Q13011,Q9BY49,O75381 4 +Potential therapeutics for sars 0.4140971205882696 1.301012329687487 0.1932542344104706 1.0 0.4775136446615083 31 P21964,P62942,P49356,Q99720 4 +Activation of caspases through apoptosome mediated cleavage 0.5603953147877062 1.2938513928530744 0.1957167568468838 1.0 0.4809748147466874 2 P55210 1 +Caspase activation via dependence receptors in the absence of ligand 0.560395314787705 1.293851392853068 0.195716756846886 1.0 0.4809748147466874 2 Q9UKG1 1 +Fgfr2 alternative splicing 0.4701746718782156 1.2907885591702348 0.1967770060488347 1.0 0.4822724731103716 17 P52597,Q01085,P31943,P09651,P31483 5 +Constitutive signaling by akt1 e17k in cancer 0.7035546794540877 1.2902768779485816 0.1969545419987168 1.0 0.4822724731103716 4 P31751 1 +Bmal1 clock npas2 activates circadian gene expression 0.6308702264632599 1.287950169886245 0.1977633096384052 1.0 0.4833819025154546 3 Q86X55 1 +Sensory perception 0.4511665827507778 1.275546558200714 0.2021158559342146 1.0 0.4874121526772074 21 O14936,P53582,P49356 3 +Long term potentiation 0.7019309738302307 1.2740658548694694 0.2026400781917749 1.0 0.4874121526772074 5 Q14168,Q13555 2 +Ras activation upon ca2 influx through nmda receptor 0.7019309738302307 1.2740658548694694 0.2026400781917749 1.0 0.4874121526772074 5 Q14168,Q13555 2 +Unblocking of nmda receptors glutamate binding and activation 0.7019309738302307 1.2740658548694694 0.2026400781917749 1.0 0.4874121526772074 5 Q14168,Q13555 2 +Negative regulation of nmda receptor mediated neuronal transmission 0.7019309738302307 1.2740658548694694 0.2026400781917749 1.0 0.4874121526772074 5 Q14168,Q13555 2 +Mitochondrial biogenesis 0.4231539807033064 1.2700293826435305 0.2040741640216881 1.0 0.4881992296207226 28 P00367,Q13505,O75431 3 +Cytochrome p450 arranged by substrate type 0.6981770377923074 1.2673869200007248 0.2050169744374428 1.0 0.4881992296207226 4 Q16850 1 +Inflammasomes 0.6994517585232883 1.263473559855626 0.2064190428195216 1.0 0.4881992296207226 5 P09601 1 +Purinergic signaling in leishmaniasis infection 0.6994517585232883 1.263473559855626 0.2064190428195216 1.0 0.4881992296207226 5 P09601 1 +The nlrp3 inflammasome 0.6994517585232883 1.263473559855626 0.2064190428195216 1.0 0.4881992296207226 5 P09601 1 +Rac3 gtpase cycle 0.4220334390801792 1.2605097901807647 0.2074855184057968 1.0 0.4881992296207226 28 Q14739,Q9UQB8,P42167,O15173,Q8TAA9,Q68EM7,P50402 7 +Synthesis of bile acids and bile salts via 7alpha hydroxycholesterol 0.6249564619276513 1.2600887528900624 0.20763734710874 1.0 0.4881992296207226 3 O14734 1 +Ire1alpha activates chaperones 0.4417692951974207 1.2414101249526708 0.2144542807033382 1.0 0.5007088987279612 22 O14773,P49840,P43307,Q9HCU5,Q9NWM8,P02545,O76024,Q9Y5M8 8 +Polo like kinase mediated events 0.6136023938365313 1.2065987978789747 0.2275866899432221 1.0 0.5215688223150741 3 Q99640 1 +Alpha linolenic omega3 and linoleic omega6 acid metabolism 0.6529821677023004 1.197479146466251 0.2311198508977892 1.0 0.5241361820076589 6 O14734,Q15067 2 +Signaling by fgfr2 0.4407429621591977 1.1967430985795415 0.2314067028731385 1.0 0.5241361820076589 21 P52597,Q01085,P62993,P31943,P09651,P31483 6 +Signaling by fgfr 0.4407429621591977 1.1967430985795415 0.2314067028731385 1.0 0.5241361820076589 21 P52597,Q01085,P62993,P31943,P09651,P31483 6 +Cd163 mediating an anti inflammatory response 0.5409956076134701 1.1914903312005036 0.2334611501159329 1.0 0.5261587114553116 2 Q16539 1 +Toll like receptor 9 tlr9 cascade 0.44840498824234 1.1897413274446398 0.2341480766138124 1.0 0.5264482578121036 19 Q8NEB9 1 +Deubiquitination 0.329423906329865 1.1680191554684902 0.2427990382528895 1.0 0.5409244147306178 79 Q9Y277,P20618,P49721,P21796,P28072,Q99436,P25054,P45880,Q96K76,P28070,Q13546 11 +Regulation of mecp2 expression and activity 0.6273492909013897 1.1636336865601664 0.2445724936901667 1.0 0.5429704648971032 7 Q14739 1 +Tysnd1 cleaves peroxisomal proteins 0.6730869866285101 1.1605871632548024 0.2458098282328265 1.0 0.5429704648971032 4 O00116,Q15067 2 +Endosomal vacuolar pathway 0.6720040007841809 1.1559800807892922 0.2476893046955692 1.0 0.5429704648971032 4 Q9UIQ6 1 +Abc family proteins mediated transport 0.3604914606799955 1.155665222731471 0.2478181184471317 1.0 0.5429704648971032 50 Q9BUN8,P28288,P20618,P49721,O75027,P28072,Q99436,P48556,P28070,P08183 10 +Fatty acid metabolism 0.3599160230175324 1.1493982709799004 0.2503917926871761 1.0 0.5461997532293297 51 P09960,P50897,Q15067,O15254,Q15165,O43772,P23786,Q16836,Q53GQ0,Q9BY49,P40939,O00767,P51648,Q9P035,Q9H7Z7 15 +Mtor signalling 0.5429380438011144 1.1170399644009927 0.2639772379665368 1.0 0.5676345987286765 11 P62942 1 +Activation of ppargc1a pgc 1alpha by phosphorylation 0.5234260614934119 1.0989836863906943 0.2717751816932774 1.0 0.5770976123768188 2 Q16539 1 +Beta oxidation of very long chain fatty acids 0.6570275212673481 1.0923296584416715 0.2746882287246659 1.0 0.5787617098245287 4 Q15067 1 +Deactivation of the beta catenin transactivating complex 0.6110141373617396 1.0872654526849346 0.2769195118379259 1.0 0.5825597779995997 7 Q13363,P31751 2 +Diseases associated with n glycosylation of proteins 0.6541776693437715 1.0802343685418314 0.2800378274341586 1.0 0.586847501449023 4 Q9BT22,O75352 2 +Pi5p regulates tp53 acetylation 0.5850322578985137 1.0722656786011322 0.2836007177968376 1.0 0.5875203894602169 3 Q8TBX8 1 +Egr2 and sox10 mediated initiation of schwann cell myelination 0.6519623084887819 1.060692783398401 0.2888295406788934 1.0 0.5916113943040836 5 Q16850 1 +Raf independent mapk1 3 activation 0.6469515285398554 1.0393626781251528 0.2986360947171342 1.0 0.6030407915610482 5 Q99956,P06493,P36507 3 +Organelle biogenesis and maintenance 0.317856144591591 1.0374508098607471 0.2995258091667903 1.0 0.6039400217472819 84 A6NIH7,P61006,O94927,O75935,O75964,O95684,Q15154,P00367,Q6UXV4,Q86X55,O43924,Q10713,A0AVF1,Q13505,O75431 15 +Cobalamin cbl vitamin b12 transport and metabolism 0.571658978380205 1.0096815379244737 0.3126478904598786 1.0 0.6202751578612775 3 Q96EY8 1 +Defects in cobalamin b12 metabolism 0.571658978380205 1.0096815379244737 0.3126478904598786 1.0 0.6202751578612775 3 Q96EY8 1 +Rhod gtpase cycle 0.4030002903093525 0.9974978928054123 0.3185228961102302 1.0 0.6268548884868014 24 Q14739,P42167,O15173,Q8TAA9,Q68EM7 5 +Unfolded protein response upr 0.362384897160277 0.9853786368710118 0.3244381192061838 1.0 0.6320481696472019 36 O14773,P49840,P43307,Q9HCU5,Q9NWM8,P02545,O76024,Q9Y5M8,Q9NQT5,Q92945,O95453 11 +Regulation of pten stability and activity 0.3534888167796339 0.981327536779731 0.3264312475766056 1.0 0.6320481696472019 42 P20618,P49721,P14373,P28072,Q99436,P48556,P28070,P31751 8 +Sars cov infections 0.3443758632031787 0.9760414412145249 0.3290439283976494 1.0 0.6333513636352807 52 Q8NEB9,Q99720,P21964,P49356,P62942,P46977 6 +Incretin synthesis secretion and inactivation 0.6293310275375006 0.9751379370935088 0.3294918425976036 1.0 0.6333513636352807 4 P67812 1 +Synthesis secretion and inactivation of glucagon like peptide 1 glp 1 0.6293310275375006 0.9751379370935088 0.3294918425976036 1.0 0.6333513636352807 4 P67812 1 +Response to elevated platelet cytosolic ca2 0.3752697320542469 0.9522691642606098 0.3409604920185405 1.0 0.6462556606041793 31 O43852,Q9BWS9,Q9NZJ7,Q9Y6I9,Q6UXV4,Q8NBX0,P05067,P07602,Q9UEU0 9 +Regulation of tp53 activity through acetylation 0.5250421327707162 0.9224093254255924 0.3563151073457948 1.0 0.65881936174549 10 Q8TBX8,P31751 2 +Synthesis of pc 0.619005461734587 0.9209611322433492 0.3570707199230498 1.0 0.6593194407274792 5 Q9NQZ5 1 +Arachidonic acid metabolism 0.5541831729628309 0.8987664291847677 0.3687770850700655 1.0 0.6692280776376487 8 P09960,Q15165 2 +Initiation of nuclear envelope ne reformation 0.4251335902835683 0.8966468120646773 0.3699074103970792 1.0 0.6702722276395074 16 P14635,Q14739,P42167,Q86XL3,P50402 5 +Mapk family signaling cascades 0.3065999211097689 0.8915596448816304 0.3726290085651438 1.0 0.673615218518131 86 Q99956,P20618,P49721,O60725,O43242,P49356,Q14168,P28072,Q99436,P62993,P07196,P48556,O43924,P28070,P36507,Q96P70,Q13555 17 +Regulation of lipid metabolism by pparalpha 0.4769526842104233 0.8801230916889221 0.3787926309574798 1.0 0.67823344594363 12 P37268,P23786 2 +Notch3 intracellular domain regulates transcription 0.4802342606149344 0.8741609249491126 0.3820306224127139 1.0 0.6813380785549583 2 P42224 1 +Ion transport by p type atpases 0.564185777562038 0.8697340076320488 0.3844457828927088 1.0 0.6820146400912458 7 Q9HD20,P16615 2 +Vitamin b5 pantothenate metabolism 0.5987099001851895 0.8470191771641393 0.3969844324373837 1.0 0.6925569238541777 4 Q13057,Q9NVE7 2 +Signaling by gpcr 0.3447202530731534 0.8347420771041352 0.4038629450362117 1.0 0.7000634468165965 38 Q9NZJ7,Q9NRV9,P07602,P42892,Q8NCG7,P05067,O43865,P31751 8 +Constitutive signaling by overexpressed erbb2 0.5322950088981481 0.8277330255642474 0.4078217114784763 1.0 0.7042308842430106 3 P62993 1 +Cd28 co stimulation 0.5388189370137285 0.8252036840003633 0.4092559622602549 1.0 0.7047166814371598 8 P62993,P31751 2 +Nucleotide binding domain leucine rich repeat containing receptor nlr signaling pathways 0.5224006643165402 0.8232766205808437 0.4103507056442876 1.0 0.7047166814371598 9 P05067,P09601 2 +Creb1 phosphorylation through nmda receptor mediated activation of ras signaling 0.5366828725036106 0.8150271549553909 0.415056766550359 1.0 0.706739223105287 8 Q14168,Q13555 2 +Gamma carboxylation hypusine formation and arylsulfatase activation 0.503694991066611 0.8111786472550269 0.417263086038413 1.0 0.7088256674077541 10 O60725,P38435,O43681 3 +Sulfur amino acid metabolism 0.5352754843818637 0.8083298162135201 0.4189007426461852 1.0 0.7107192375233031 8 Q13126,Q9UBX3 2 +Neurexins and neuroligins 0.534636104590792 0.8052892654971809 0.42065277481053 1.0 0.7127710953774555 8 Q14168 1 +Toll like receptor cascades 0.3751570627723041 0.7738566962876394 0.4390155401210101 1.0 0.7369807283368165 24 P05067,Q8NEB9 2 +Rhoc gtpase cycle 0.3619935486310432 0.7735230344941385 0.4392129019081161 1.0 0.7369807283368165 29 P28288,Q14739,P42167,P41440,Q8TAA9,Q13190 6 +Beta oxidation of lauroyl coa to decanoyl coa coa 0.5804445856447482 0.7717404969685596 0.4402681401853132 1.0 0.7369807283368165 4 Q16836 1 +Beta oxidation of hexanoyl coa to butanoyl coa 0.5804445856447482 0.7717404969685596 0.4402681401853132 1.0 0.7369807283368165 4 Q16836 1 +Intra golgi traffic 0.5119683986655503 0.7716113845474645 0.4403446294403936 1.0 0.7369807283368165 9 O00461 1 +Regulation of hmox1 expression and activity 0.3277254636277499 0.7653494790051472 0.4440634680950022 1.0 0.7404690222590281 45 Q8TCT9,P49721,P20618,P28072,Q99436,P48556,P09601,P28070 8 +Met activates ras signaling 0.5752145385955434 0.7503905190319502 0.4530195394031215 1.0 0.7498628640494074 4 P62993 1 +Degradation of beta catenin by the destruction complex 0.3221430238002841 0.725372594114718 0.4682234814035855 1.0 0.7629009220122996 48 P20618,P49721,P48729,P28072,Q99436,P25054,Q13363,P48556,P28070 9 +Downstream signaling events of b cell receptor bcr 0.3298345849237306 0.7232735109053055 0.4695118635746635 1.0 0.7629009220122996 41 P20618,P49721,P28072,Q99436,P62942,P48556,P28070 7 +Traf6 mediated irf7 activation 0.4458272327964813 0.700621246747834 0.4835394153372041 1.0 0.7765591795002185 2 Q7Z434 1 +Traf3 dependent irf activation pathway 0.4458272327964813 0.700621246747834 0.4835394153372041 1.0 0.7765591795002185 2 Q7Z434 1 +Heme signaling 0.5651840083457867 0.6978756470838561 0.4852549654583069 1.0 0.7765591795002185 5 P09601 1 +Activation of nmda receptors and postsynaptic events 0.3763856009747957 0.6856666583092261 0.4929233364829164 1.0 0.7794718167816206 20 O14936,Q14168,Q13555 3 +Glycosphingolipid metabolism 0.4115786466688205 0.6849780593067296 0.4933577662850053 1.0 0.7794718167816206 14 P07602,P04062,Q9NZJ7 3 +Methylation 0.5368542222502116 0.6820916070323905 0.4951810273462023 1.0 0.7794718167816206 6 P21964 1 +Ion homeostasis 0.4930017264161292 0.6787773780752687 0.4972789294699522 1.0 0.7794718167816206 9 O43865,P16615,Q13555 3 +Cardiac conduction 0.4930017264161292 0.6787773780752687 0.4972789294699522 1.0 0.7794718167816206 9 O43865,P16615,Q13555 3 +Adrenaline noradrenaline inhibits insulin secretion 0.4407027818448003 0.6754404723375276 0.4993959593355868 1.0 0.7818883741210397 2 P04899 1 +Protein ubiquitination 0.3615396879563484 0.6654925001728279 0.5057355388954858 1.0 0.7872790347754471 24 O75381,P60604 2 +Intracellular signaling by second messengers 0.2917869939169761 0.6449966992736027 0.5189293247124394 1.0 0.8032174855173179 76 P20618,P49721,P14373,Q8TBX8,P28072,Q99436,P62993,P48556,P28070,O43865,P31751,Q13555 12 +Cyclin a cdk2 associated events at s phase entry 0.3204547338355132 0.6414740055759482 0.5212147644174123 1.0 0.8049141423755994 42 P20618,P49721,P28072,Q99436,P48556,P28070,P31751 7 +Dap12 interactions 0.551109946922177 0.6412779377965591 0.5213421205671802 1.0 0.8049141423755994 5 P62993 1 +Hedgehog on state 0.3202123437512197 0.6390052038171031 0.5228195466020098 1.0 0.805568893233709 42 P20618,P49721,P48729,P28072,Q99436,P48556,P28070,Q96J02 8 +Purine salvage 0.5409768608474311 0.6011426140138418 0.5477450024322601 1.0 0.8234352414883203 5 P55263 1 +Metabolism of folate and pterines 0.4897366132298024 0.5960607889495304 0.5511346176846357 1.0 0.8248469881214998 8 P41440,Q9H2D1 2 +Abc transporter disorders 0.3156576489615583 0.5927368995174922 0.5533572427730125 1.0 0.8248469881214998 42 Q9BUN8,P20618,P49721,P28072,Q99436,P48556,P28070 7 +Defective cftr causes cystic fibrosis 0.3156576489615583 0.5927368995174922 0.5533572427730125 1.0 0.8248469881214998 42 Q9BUN8,P20618,P49721,P28072,Q99436,P48556,P28070 7 +Leishmania infection 0.3371836523989089 0.585018504445095 0.5585352744670058 1.0 0.8248469881214998 30 P05067,O43865,P09601,Q9UQB8 4 +Cytoprotection by hmox1 0.304269451141423 0.5838183576787924 0.5593425259850142 1.0 0.8248469881214998 61 Q8TCT9,P13073,P49721,P20618,O43242,P28072,Q99436,P48556,P09601,P30043,P28070,P30519 12 +Stimuli sensing channels 0.5001474060481031 0.5823425286834232 0.560335984522661 1.0 0.8248469881214998 7 P27105,P51790,Q13546 3 +Signaling by wnt in cancer 0.4726307327526593 0.5811685733739763 0.5611268459624941 1.0 0.8248469881214998 9 Q13363,P25054 2 +Fc epsilon receptor fceri signaling 0.3081741014951615 0.5809404551766989 0.5612805855799059 1.0 0.8248469881214998 49 P20618,P49721,O43242,P28072,Q99436,P62993,P48556,P28070,O43865 9 +Disorders of transmembrane transporters 0.2895204244275912 0.573712871676355 0.566162116608731 1.0 0.8291680232985289 73 Q9UL46,Q99567,Q9BUN8,P11166,O43242,Q99436,P57740,Q9UBV2,P49721,Q9NRG9,P28070,P08195,Q8N1F7,Q8NFH4,P53985,P20618,P28072,P48556,Q9BTX1,P28074,Q92621 21 +Chondroitin sulfate dermatan sulfate metabolism 0.5306292759063246 0.573392283428274 0.5663791139168235 1.0 0.8291680232985289 4 Q8NCH0 1 +Diseases associated with glycosaminoglycan metabolism 0.5306292759063246 0.573392283428274 0.5663791139168235 1.0 0.8291680232985289 4 Q8NCH0 1 +Nuclear signaling by erbb4 0.4741852801171732 0.5713011143652809 0.567795546468318 1.0 0.8291680232985289 3 P61201,Q92542 2 +Josephin domain dubs 0.4690589527645553 0.5497726328030951 0.5824753316926028 1.0 0.842490626696328 3 P54727,P54725 2 +Fgfr1 mutant receptor activation 0.4628022611728786 0.5350685415332732 0.5926024622391637 1.0 0.8505326470343827 9 O95429,O95684 2 +Rnd2 gtpase cycle 0.3869464500306788 0.5349539656980732 0.5926816900232232 1.0 0.8505326470343827 14 Q8TAA9,Q07065,P51648 3 +Transcriptional regulation by mecp2 0.4478523970570098 0.5292561998510631 0.5966277354097611 1.0 0.8534916762335425 10 Q14739 1 +Tnf signaling 0.5221006261818175 0.5279893567762463 0.5975067231016951 1.0 0.8538503014670911 5 O95429,Q13546 2 +Cdc42 gtpase cycle 0.3392228411434504 0.519724600393265 0.603255538238415 1.0 0.8602388799910347 26 Q14739,Q9UQB8,P42167,Q8TAA9,Q68EM7,Q13153 6 +Heme biosynthesis 0.4971066519683856 0.5165362840969775 0.6054799037921477 1.0 0.8616200934591923 6 P36551 1 +Phosphorylation of emi1 0.4582767020165775 0.5052528492092472 0.6133812551996447 1.0 0.8695876025198813 3 P14635 1 +Regulation of runx3 expression and activity 0.3118766522311121 0.4998204162743347 0.6172015335346885 1.0 0.8715115437008024 36 P20618,P49721,P28072,Q99436,P48556,P28070 6 +Pten regulation 0.2992088630042232 0.4969199638479505 0.6192454927006785 1.0 0.872829859296873 58 P20618,P49721,P14373,P28072,Q99436,P48556,P28070,P31751 8 +The citric acid tca cycle and respiratory electron transport 0.2790342167513357 0.4942025547843867 0.6211631356676988 1.0 0.8729686673964867 84 Q86Y39,P13073,O75964,P21796,O95168,O14949,P21912,O75306,Q7L592,O96000,O43676,Q9UDW1 12 +Transcriptional regulation by runx2 0.2980995627826729 0.4684317321368673 0.6394758801358895 1.0 0.8867686559919103 50 P20618,P14635,P49721,P28066,O43242,P11802,P28072,Q99436,P60900,P48556,P28070,P28074,P49720,P31751,Q9UL46,Q96PK6 16 +Cilium assembly 0.2965883947794469 0.4524995452621727 0.6509091487624725 1.0 0.8965098222798037 56 A6NIH7,O94927,P61006,O75935,O95684,Q15154,O43924,Q10713,A0AVF1 9 +Ethanol oxidation 0.4441596484804103 0.4486937968629544 0.6536525600644381 1.0 0.8965098222798037 3 P11766,P30837 2 +Degradation of gli1 by the proteasome 0.3015405834506062 0.4407125095683571 0.6594211391106664 1.0 0.8965098222798037 41 P20618,P49721,P28072,Q99436,P48556,P28070,Q96J02 7 +Antigen processing ubiquitination proteasome degradation 0.2752078761661432 0.4382145590697143 0.6612307555913297 1.0 0.8965098222798037 83 P20618,P49721,Q9UIQ6,P28072,Q99436,P28070,Q9UJX4,Q96J02,Q05086,P60604,P55786 11 +Adp signalling through p2y purinoceptor 12 0.4408641523251556 0.4357999537663605 0.6629818774033869 1.0 0.8965098222798037 3 P08754,P04899 2 +G alpha z signalling events 0.4408641523251556 0.4357999537663605 0.6629818774033869 1.0 0.8965098222798037 3 P08754,P04899 2 +Adenylate cyclase inhibitory pathway 0.4408641523251556 0.4357999537663605 0.6629818774033869 1.0 0.8965098222798037 3 P08754,P04899 2 +Gaba receptor activation 0.4408641523251556 0.4357999537663605 0.6629818774033869 1.0 0.8965098222798037 3 P08754,P04899 2 +Gaba b receptor activation 0.4408641523251556 0.4357999537663605 0.6629818774033869 1.0 0.8965098222798037 3 P08754,P04899 2 +Sars cov 2 infection 0.337139461374304 0.4218161419897647 0.67315922254698 1.0 0.9019706739210434 21 Q8NEB9 1 +Sensory processing of sound by outer hair cells of the cochlea 0.4119512391749933 0.4201432707177108 0.6743807939552515 1.0 0.9019706739210434 11 O14936 1 +Hiv transcription initiation 0.3755526497037242 0.4194597045146184 0.6748801980100927 1.0 0.9019706739210434 13 P19447,P29083,Q92804 3 +Class i mhc mediated antigen processing presentation 0.2654124087284416 0.4104853637675551 0.6814499379235024 1.0 0.9062834840578988 102 P01889,P20618,P49721,O95487,Q9UIQ6,P28072,Q99436,P28070,Q9UJX4,Q96J02,Q05086,P51572,P60604,P55786 14 +Degradation of axin 0.3004675764111299 0.399442195442296 0.689567408121208 1.0 0.9133743739149334 37 P20618,P49721,P28072,Q99436,P48556,P28070 6 +Costimulation by the cd28 family 0.388745867271256 0.3938900688795825 0.6936622027880937 1.0 0.9152300326106982 12 P62993,P31751 2 +Nef and signal transduction 0.3777452415812539 0.388684851903248 0.6975092894100683 1.0 0.9166446648126156 2 Q13177 1 +Negative regulation of the pi3k akt network 0.4053771464619388 0.388295270553787 0.697797536792375 1.0 0.9166446648126156 11 P62993,P31751 2 +Diseases of immune system 0.3766471449487523 0.3841636669662426 0.700857145548758 1.0 0.9193676262555618 2 P09429 1 +Asymmetric localization of pcp proteins 0.2975058519018604 0.3780030372408612 0.7054283376998765 1.0 0.9225604462249868 38 P20618,P49721,P28072,Q99436,P48556,P28070 6 +Neuronal system 0.288997411905713 0.3620604281190477 0.7173068741209216 1.0 0.9290860618840336 45 P21964,O95197,Q14168,P41440,O14936,Q13555 6 +Cdt1 association with the cdc6 orc origin complex 0.2954768962455996 0.3592033910174743 0.7194429400231872 1.0 0.9290860618840336 38 Q9Y619,P20618,P49721,P28066,O43242,P28072,Q99436,P60900,P48556,P28070,P28074,Q9UL46 12 +Interferon gamma signaling 0.3990056309670532 0.3579598379969255 0.720373369334377 1.0 0.9290860618840336 11 P01889,Q13555 2 +Cross presentation of soluble exogenous antigens endosomes 0.2951186409050857 0.3558949753288911 0.7219192188772088 1.0 0.9290860618840336 38 P20618,P49721,P28066,O43242,P28072,Q99436,Q9UBG0,P60900,P48556,P28070,P28074,Q9UL46 12 +Degradation of dvl 0.2950169049375244 0.3549560826454981 0.7226224925764706 1.0 0.9290860618840336 38 P20618,P49721,P28072,Q99436,P48556,P28070 6 +Regulation of ras by gaps 0.2950169049375244 0.3549560826454981 0.7226224925764706 1.0 0.9290860618840336 38 P20618,P49721,P28072,Q99436,P48556,P28070 6 +Metabolism of polyamines 0.2947590717196199 0.3525778449479071 0.7244049494150868 1.0 0.9291787360794986 38 P19623,P49721,P20618,P28066,O43242,P28072,Q99436,P60900,P48556,P28070,P28074,Q9UL46 12 +G protein beta gamma signalling 0.4734709986942497 0.3521233739472402 0.7247457396940902 1.0 0.9291787360794986 5 P31751 1 +G protein mediated events 0.4096807404353577 0.3507941592443044 0.7257427793540165 1.0 0.9295800538568412 10 O43865 1 +Signaling by fgfr1 in disease 0.4075274658947475 0.3412404870091589 0.7329225462265798 1.0 0.9361294551897764 10 O95429,O95684 2 +Pi3k akt signaling in cancer 0.4169915182891124 0.3321388867203038 0.7397843878804045 1.0 0.9431209973071948 9 P62993,P31751,P49840 3 +Rho gtpase cycle 0.2608825714322382 0.3223579891226594 0.7471815067084169 1.0 0.9457598886930793 137 P62993,P41440,Q8TAA9,Q13505,Q86XL3,P51648,P28288,Q99707,Q68EM7,O75323,Q07065,Q13190,P62995,P08670,Q13153,O95202,P38159,O15173,P30519,P27105,Q14739,Q9UQB8,P42167,P51572,P50402 25 +Fatty acyl coa biosynthesis 0.3573285072744622 0.3215733427584423 0.747775941369351 1.0 0.9457598886930793 13 P50897,O00767,O60488,Q53GQ0,Q9UMR5,Q9P035 6 +Transcriptional regulation by runx3 0.29053272656289 0.3198156661429367 0.749108070991612 1.0 0.9461281382414028 39 P20618,P49721,P28072,Q99436,P48556,P28070 6 +Transport of vitamins nucleosides and related molecules 0.4242035396961049 0.3169817755826091 0.7512574307215836 1.0 0.9462169459863936 8 P05141,Q8TB61,P12236,Q99808 4 +Antigen processing cross presentation 0.282012556596167 0.3039418489915585 0.761172194170628 1.0 0.9507656359171722 49 P20618,P49721,Q9UIQ6,P28072,Q99436,P48556,P28070,P01889 8 +Ovarian tumor domain proteases 0.4082812513927895 0.2963854261042698 0.7669357539039239 1.0 0.9549402153927434 9 P25054,Q13546,P06493,Q96FW1 4 +Hedgehog ligand biogenesis 0.2849716275406116 0.2752035488294048 0.7831598606319452 1.0 0.9661985387650208 40 P20618,P49721,P28066,O43242,P28072,Q99436,P60900,P48556,P28070,P28074,Q9UBV2,Q9UL46 12 +Regulation of innate immune responses to cytosolic dna 0.3921640424752838 0.26179776468505 0.7934773625044407 1.0 0.972349626369283 3 P19474,Q9NZI8 2 +Triglyceride metabolism 0.4183910518761524 0.2587438163371114 0.7958329098915691 1.0 0.9734805801463928 7 Q9HCL2 1 +Dag and ip3 signaling 0.4149330828173765 0.2467965609666572 0.8050656721351817 1.0 0.9802493204817876 7 O43865 1 +Beta catenin phosphorylation cascade 0.4144901519041346 0.2452789464395978 0.8062404522350803 1.0 0.9802493204817876 7 P25054 1 +Disassembly of the destruction complex and recruitment of axin to the membrane 0.4144901519041346 0.2452789464395978 0.8062404522350803 1.0 0.9802493204817876 7 P25054 1 +Signaling by ctnnb1 phospho site mutants 0.4144901519041346 0.2452789464395978 0.8062404522350803 1.0 0.9802493204817876 7 P25054 1 +Rhobtb1 gtpase cycle 0.3134704543275396 0.2384799069096894 0.8115088978114708 1.0 0.9844342417327964 19 Q99832,P38159,Q9BT78,P07910,P62995,P08670 6 +Clec7a dectin 1 signaling 0.2760518275978967 0.2346620292954417 0.814471061071151 1.0 0.9857277984024316 45 P20618,P49721,P28072,Q99436,P48556,P28070,O43865 7 +G1 s dna damage checkpoints 0.2803441520187019 0.2330994468947174 0.8156841843899048 1.0 0.9857277984024316 40 P20618,P49721,P28072,Q99436,P48556,P28070 6 +Stabilization of p53 0.2807889887846462 0.2314525127274554 0.8169632731959191 1.0 0.9857277984024316 39 P20618,P49721,P28072,Q99436,P48556,P28070 6 +C type lectin receptors clrs 0.274788630357994 0.2308253333158428 0.8174504994845773 1.0 0.9857277984024316 49 P20618,P49721,O43242,P28072,Q99436,P48556,P28070,O43865 8 +Rnd1 gtpase cycle 0.35298797215014 0.2210296147943431 0.8250693739143229 1.0 0.9904212546227126 12 Q8TAA9,P51648 2 +Slc transporter disorders 0.2907717363159818 0.220591268432289 0.8254107003787554 1.0 0.9904212546227126 31 Q8NFH4,P11166,P53985,Q9BTX1,Q9NRG9,P57740,P08195,Q99567,Q8N1F7 9 +Signaling by ptk6 0.3784934787585985 0.2192642281095088 0.8264442257116675 1.0 0.9904212546227126 10 P23246,O75525,Q07666 3 +Hedgehog off state 0.2742221335460006 0.2148785175050102 0.8298620342226115 1.0 0.9918931438069736 51 P20618,P49721,P48729,P28072,Q99436,P48556,P28070,Q96J02 8 +Ddx58 ifih1 mediated induction of interferon alpha beta 0.3203180920182582 0.1947341835462411 0.8456010495704955 1.0 1.0 15 P05067,Q13546 2 +Ripk1 mediated regulated necrosis 0.3607345794063814 0.189122581776886 0.849996743154438 1.0 1.0 11 P41440 1 +Rac1 gtpase cycle 0.2798166432045869 0.1887890260849485 0.8502581730962566 1.0 1.0 34 Q14739,Q9UQB8,P42167,Q8TAA9,Q68EM7,P50402 6 +E3 ubiquitin ligases ubiquitinate target proteins 0.313254896604418 0.188015845900305 0.8508642294675433 1.0 1.0 16 O75381 1 +Rora activates gene expression 0.3667882446851481 0.1858488130911678 0.8525633239867632 1.0 1.0 3 Q86X55 1 +Antigen presentation folding assembly and peptide loading of class i mhc 0.3288929564128823 0.1808491473138437 0.8564859851130757 1.0 1.0 13 P01889,P51572 2 +Metabolism of steroid hormones 0.3940310965002038 0.178495764482174 0.8583336472390468 1.0 1.0 7 O95772 1 +Runx1 regulates transcription of genes involved in differentiation of hscs 0.27396636395164 0.1763949814998841 0.8599836470329549 1.0 1.0 40 P20618,P49721,P28072,Q99436,P48556,P28070,Q96J02 7 +Striated muscle contraction 0.3909305737743309 0.1689688638702503 0.8658211322509024 1.0 1.0 7 P08670 1 +Tp53 regulates transcription of cell death genes 0.3595752471622117 0.1663849586196404 0.8678540102472916 1.0 1.0 3 P49327,P55212 2 +Death receptor signalling 0.2984971238127062 0.1641362353782208 0.8696238969182875 1.0 1.0 21 O95429,Q9NQC3 2 +Signaling by notch 0.2703514986718776 0.1631534847336141 0.8703975891865467 1.0 1.0 54 P20618,P49721,P28072,Q99436,P67809,P48556,P28070,Q96J02,P16615 9 +Scf skp2 mediated degradation of p27 p21 0.2709633761720511 0.1555324711767419 0.8764015571030033 1.0 1.0 41 P20618,P49721,P28066,O43242,P11802,P28072,Q99436,P60900,P48556,P28070,P28074,Q9UL46 12 +Tcf dependent signaling in response to wnt 0.26816003289455 0.1518855499480861 0.8792772055309284 1.0 1.0 57 P20618,P49721,P48729,P28072,Q99436,P25054,Q13363,P48556,P28070,P31751 10 +Rhoq gtpase cycle 0.2998685601018085 0.1515915872498498 0.8795090691221283 1.0 1.0 18 Q68EM7 1 +Cellular response to hypoxia 0.2705565119478139 0.1467773025809047 0.8833078005453179 1.0 1.0 40 P20618,P49721,P28072,Q99436,P48556,P28070 6 +Regulation of insulin secretion 0.3497610926112015 0.1457780121443611 0.8840966342202985 1.0 1.0 11 P11166,O43865 2 +Sensory processing of sound 0.3099375622955281 0.1421385172697862 0.8869705946442463 1.0 1.0 15 O14936 1 +Mitotic g1 phase and g1 s transition 0.2568327849997378 0.1351551078589067 0.8924892400733704 1.0 1.0 71 Q9Y619,P11802,Q9UL46,P14635,Q9NRF9,P28066,O43242,P25205,Q99436,Q14566,P49721,P04818,P60900,P28070,P49720,P31751,P15927,Q14181,P20618,P28072,P48556,P28074,P31350 23 +Cd28 dependent vav1 pathway 0.3834717744314498 0.12883940167611 0.8974847273113262 1.0 1.0 6 P62993 1 +Signaling by erbb2 0.3621017958473294 0.1273768222822804 0.8986421599393342 1.0 1.0 9 P31751 1 +Rhoh gtpase cycle 0.2930363016791691 0.1232983072907151 0.9018708811927824 1.0 1.0 20 O75323,Q99707,Q8TAA9,Q13153 4 +Regulation of tnfr1 signaling 0.3860120632201219 0.1201892444197837 0.9043332377221768 1.0 1.0 4 Q13546 1 +Negative regulation of notch4 signaling 0.2673633377880272 0.1195239870821501 0.9048602373090904 1.0 1.0 40 P20618,P49721,P28072,Q99436,P48556,P28070 6 +Signaling by cytosolic fgfr1 fusion mutants 0.3713386887738139 0.1126582263678972 0.9103015208648776 1.0 1.0 7 O95684 1 +Activation of nima kinases nek9 nek6 nek7 0.3783882783882805 0.1040744652191735 0.9171102545986204 1.0 1.0 4 Q8TD19,P06493,P14635 3 +Ephrin signaling 0.3780219780219802 0.1033237026406261 0.9177060643073824 1.0 1.0 4 Q13153,Q13177,Q16512 3 +Sumoylation of rna binding proteins 0.2801158060714042 0.1017705755704595 0.9189387816487152 1.0 1.0 28 Q8NFH4,Q9BTX1,Q9NRG9,P57740,P07910,P61978,Q99567,Q8N1F7 8 +Negative regulators of ddx58 ifih1 signaling 0.3714892519903491 0.0989102271361235 0.9212095486476456 1.0 1.0 6 Q96J02,Q13526 2 +Signaling by notch4 0.263666347603278 0.0979209920985111 0.9219950308078408 1.0 1.0 42 P20618,P49721,P28072,Q99436,P48556,P28070 6 +Opioid signalling 0.3033069604080195 0.0905117636403392 0.9278805462907488 1.0 1.0 14 O43865 1 +Fceri mediated nf kb activation 0.2631951698422528 0.0888650380552711 0.9291891691777046 1.0 1.0 41 P20618,P49721,P28072,Q99436,P48556,P28070 6 +Fceri mediated mapk activation 0.361905034080897 0.0880443974690693 0.9298413890541776 1.0 1.0 7 P62993 1 +Cd209 dc sign signaling 0.377061194576761 0.0855811540115167 0.9317993804067202 1.0 1.0 5 Q13153,P17612,Q13177,Q16512 4 +Cargo recognition for clathrin mediated endocytosis 0.2739571848615766 0.0809884565571157 0.9354511326802672 1.0 1.0 30 Q7L5N1,P51809,Q14108 3 +Sumoylation of ubiquitinylation proteins 0.2800324183112554 0.0793165585390678 0.9367808359850188 1.0 1.0 25 Q8NFH4,P14373,Q9BTX1,Q9NRG9,P57740,Q99567,Q8N1F7 7 +Signaling by receptor tyrosine kinases 0.2444944785929693 0.0784702974580736 0.9374539565435348 1.0 1.0 98 Q93050,P36507,Q8NEB9,Q9UQB8,P52597,Q01085,P31943,P62993,Q96P70,Q96J02,P09651,O43865,Q13153,Q9Y487,P31751,P31483 16 +Dectin 1 mediated noncanonical nf kb signaling 0.2603720299680294 0.0654008776913636 0.947854825281122 1.0 1.0 41 P20618,P49721,P28072,Q99436,P48556,P28070 6 +Tnfr2 non canonical nf kb pathway 0.2603720299680294 0.0654008776913636 0.947854825281122 1.0 1.0 41 P20618,P49721,P28072,Q99436,P48556,P28070 6 +Muscle contraction 0.2763843865028864 0.061942983823861 0.9506082370575836 1.0 1.0 26 Q13555,P09493,O43865,Q13153,P16615,P08670 6 +Orc1 removal from chromatin 0.256831225855243 0.0580034069759008 0.953745914723582 1.0 1.0 48 Q9Y619,Q14566,P49721,P20618,P28066,O43242,P25205,P28072,Q99436,P60900,P48556,P28070,P28074,Q9UL46 14 +Translation of sars cov 1 structural proteins 0.3519061583577719 0.05549790508585 0.9557417988791884 1.0 1.0 6 P49840,Q13724,P14314,P27824,P49841 5 +Maturation of sars cov 1 spike protein 0.3516483516483536 0.0549702235001454 0.9561621861161532 1.0 1.0 4 Q13724,P14314,P27824 3 +Depolymerisation of the nuclear lamina 0.33742582804268 0.0540041260845482 0.9569318769008706 1.0 1.0 9 P42167,P50402,P14635 3 +Copii mediated vesicle transport 0.274524551737939 0.0503407278206832 0.9598508687883438 1.0 1.0 26 P53634,Q13190,O15027,O95487 4 +Interleukin 1 signaling 0.2559176814269059 0.0496702741335067 0.9603851450140776 1.0 1.0 46 P20618,P49721,P28072,Q99436,P48556,P28070,P05067 7 +Transcription of the hiv genome 0.2753415852176026 0.0465741814081992 0.9628526099448788 1.0 1.0 24 Q92804 1 +Regulation of runx2 expression and activity 0.2565239050246156 0.0430753866725203 0.9656414396732385 1.0 1.0 43 P20618,P49721,P28072,Q99436,P48556,P28070 6 +Fcgamma receptor fcgr dependent phagocytosis 0.2757330311812988 0.0430381623164143 0.9656711128941258 1.0 1.0 23 P62993,O43865,Q9UQB8 3 +Recycling of eif2 gdp 0.3421240196030365 0.0419586206152132 0.9665316850121336 1.0 1.0 7 P49770,Q9NR50 2 +Maturation of sars cov 2 nucleoprotein 0.3505331181516881 0.0370577512886928 0.970438958459547 1.0 1.0 5 P48729 1 +Cellular response to chemical stress 0.2477698902472538 0.0319335891067621 0.9745250120582158 1.0 1.0 71 Q8TCT9,P13073,P49721,P20618,O43242,Q8TED1,P28072,Q99436,P48556,P09601,P30043,P28070,P30519 13 +Tp53 regulates transcription of genes involved in g2 cell cycle arrest 0.3330887747615553 0.0305439551446472 0.9756332385832276 1.0 1.0 8 P14635,Q9Y3B8,P06493,Q99873,Q86X55,P04637,P12004 7 +Recruitment of mitotic centrosome proteins and complexes 0.267259930408359 0.025908406595069 0.9793303948053468 1.0 1.0 29 O94927,Q96CW5,O75935,O95684,Q15154,Q9BSJ2,Q9H6D7 7 +Diseases of carbohydrate metabolism 0.3219628105479985 0.0148546442147975 0.98814814459903 1.0 1.0 9 P08236,P54802 2 +G alpha s signalling events 0.3227106227106248 0.0146503636868304 0.9883111191425252 1.0 1.0 4 P63096,P08754,P04899 3 +Perk regulates gene expression 0.2991773118432701 0.012546400100882 0.9899896836907842 1.0 1.0 12 Q92945,Q96B26,O95453,Q9NQT5 4 +Oncogene induced senescence 0.3338219127885617 0.0123262117059439 0.9901653550258792 1.0 1.0 5 Q9HCE1,P11802,P28482,P04637 4 +Processing of smdt1 0.3097842010883764 0.0116385316554269 0.9907140049219184 1.0 1.0 11 Q8WWC4,Q10713 2 +Signal transduction by l1 0.3181651376146809 0.0060705053178477 0.9951564672788348 1.0 1.0 9 P05556,P63000,P67870,Q16512,Q02750,P28482,P36507,Q13153 8 +Signaling by egfr in cancer 0.3114720927872441 0.0023889475401111 0.9980938974542212 1.0 1.0 4 P62993 1 +Constitutive signaling by egfrviii 0.3114720927872441 0.0023889475401111 0.9980938974542212 1.0 1.0 4 P62993 1 +Signaling by erbb2 ecd mutants 0.3114720927872441 0.0023889475401111 0.9980938974542212 1.0 1.0 4 P62993 1 +Signaling by erbb2 in cancer 0.3114720927872441 0.0023889475401111 0.9980938974542212 1.0 1.0 4 P62993 1 +Constitutive signaling by ligand responsive egfr cancer variants 0.3114720927872441 0.0023889475401111 0.9980938974542212 1.0 1.0 4 P62993 1 diff --git a/msigdb_reactome/selections.json b/msigdb_reactome/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..2e18284456e34f91850c1efba2a5ea8a1689e378 --- /dev/null +++ b/msigdb_reactome/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["2 ltr circle formation", "A tetrasaccharide linker sequence is required for gag synthesis", "Abacavir metabolism", "Abacavir transmembrane transport", "Abacavir transport and metabolism", "Abc family proteins mediated transport", "Abc transporter disorders", "Abc transporters in lipid homeostasis", "Aberrant regulation of mitotic exit in cancer due to rb1 defects", "Aberrant regulation of mitotic g1 s transition in cancer due to rb1 defects", "Abortive elongation of hiv 1 transcript in the absence of tat", "Acetylcholine neurotransmitter release cycle", "Acetylcholine regulates insulin secretion", "Activated notch1 transmits signal to the nucleus", "Activated ntrk2 signals through cdk5", "Activated ntrk2 signals through frs2 and frs3", "Activated ntrk2 signals through fyn", "Activated ntrk2 signals through pi3k", "Activated ntrk2 signals through ras", "Activated ntrk3 signals through ras", "Activated pkn1 stimulates transcription of ar androgen receptor regulated genes klk2 and klk3", "Activated tak1 mediates p38 mapk activation", "Activation of ampk downstream of nmdars", "Activation of anterior hox genes in hindbrain development during early embryogenesis", "Activation of atr in response to replication stress", "Activation of bad and translocation to mitochondria", "Activation of bh3 only proteins", "Activation of caspases through apoptosome mediated cleavage", "Activation of gene expression by srebf srebp", "Activation of kainate receptors upon glutamate binding", "Activation of nima kinases nek9 nek6 nek7", "Activation of nmda receptors and postsynaptic events", "Activation of noxa and translocation to mitochondria", "Activation of ppargc1a pgc 1alpha by phosphorylation", "Activation of puma and translocation to mitochondria", "Activation of rac1", "Activation of rac1 downstream of nmdars", "Activation of smo", "Activation of the ap 1 family of transcription factors", "Activation of the mrna upon binding of the cap binding complex and eifs and subsequent binding to 43s", "Activation of the pre replicative complex", "Activation of the tfap2 ap 2 family of transcription factors", "Acyl chain remodeling of cl", "Acyl chain remodelling of pc", "Acyl chain remodelling of pe", "Acyl chain remodelling of pg", "Acyl chain remodelling of pi", "Acyl chain remodelling of ps", "Adaptive immune system", "Adenylate cyclase inhibitory pathway", "Adherens junctions interactions", "Adora2b mediated anti inflammatory cytokines production", "Adp signalling through p2y purinoceptor 1", "Adp signalling through p2y purinoceptor 12", "Adrenaline noradrenaline inhibits insulin secretion", "Advanced glycosylation endproduct receptor signaling", "Aflatoxin activation and detoxification", "Aggrephagy", "Akt phosphorylates targets in the cytosol", "Akt phosphorylates targets in the nucleus", "Alk mutants bind tkis", "Alpha linolenic omega3 and linoleic omega6 acid metabolism", "Alpha oxidation of phytanate", "Amino acid transport across the plasma membrane", "Amino acids regulate mtorc1", "Amyloid fiber formation", "Anchoring of the basal body to the plasma membrane", "Androgen biosynthesis", "Anti inflammatory response favouring leishmania parasite infection", "Antigen activates b cell receptor bcr leading to generation of second messengers", "Antigen presentation folding assembly and peptide loading of class i mhc", "Antigen processing cross presentation", "Antigen processing ubiquitination proteasome degradation", "Antimicrobial peptides", "Antiviral mechanism by ifn stimulated genes", "Apc c cdc20 mediated degradation of cyclin b", "Apc c cdh1 mediated degradation of cdc20 and other apc c cdh1 targeted proteins in late mitosis early g1", "Apc c mediated degradation of cell cycle proteins", "Apc cdc20 mediated degradation of nek2a", "Apex1 independent resolution of ap sites via the single nucleotide replacement pathway", "Apobec3g mediated resistance to hiv 1 infection", "Apoptosis", "Apoptosis induced dna fragmentation", "Apoptotic cleavage of cell adhesion proteins", "Apoptotic cleavage of cellular proteins", "Apoptotic execution phase", "Apoptotic factor mediated response", "Aquaporin mediated transport", "Arachidonate production from dag", "Arachidonic acid metabolism", "Arms mediated activation", "Aryl hydrocarbon receptor signalling", "Asparagine n linked glycosylation", "Aspartate and asparagine metabolism", "Assembly and cell surface presentation of nmda receptors", "Assembly of collagen fibrils and other multimeric structures", "Assembly of the hiv virion", "Assembly of the orc complex at the origin of replication", "Association of tric cct with target proteins during biosynthesis", "Asymmetric localization of pcp proteins", "Atf4 activates genes in response to endoplasmic reticulum stress", "Atf6 atf6 alpha activates chaperone genes", "Atf6 atf6 alpha activates chaperones", "Attachment and entry", "Attachment of gpi anchor to upar", "Attenuation phase", "Auf1 hnrnp d0 binds and destabilizes mrna", "Aurka activation by tpx2", "Autophagy", "B wich complex positively regulates rrna expression", "Base excision repair", "Base excision repair ap site formation", "Basigin interactions", "Bbsome mediated cargo targeting to cilium", "Beta catenin independent wnt signaling", "Beta catenin phosphorylation cascade", "Beta oxidation of butanoyl coa to acetyl coa", "Beta oxidation of decanoyl coa to octanoyl coa coa", "Beta oxidation of hexanoyl coa to butanoyl coa", "Beta oxidation of lauroyl coa to decanoyl coa coa", "Beta oxidation of octanoyl coa to hexanoyl coa", "Beta oxidation of pristanoyl coa", "Beta oxidation of very long chain fatty acids", "Bh3 only proteins associate with and inactivate anti apoptotic bcl 2 members", "Bile acid and bile salt metabolism", "Binding and uptake of ligands by scavenger receptors", "Binding of tcf lef ctnnb1 to target gene promoters", "Biological oxidations", "Biosynthesis of epa derived spms", "Biosynthesis of maresins", "Biosynthesis of specialized proresolving mediators spms", "Biosynthesis of the n glycan precursor dolichol lipid linked oligosaccharide llo and transfer to a nascent protein", "Biotin transport and metabolism", "Bmal1 clock npas2 activates circadian gene expression", "Branched chain amino acid catabolism", "Budding and maturation of hiv virion", "Butyrate response factor 1 brf1 binds and destabilizes mrna", "C type lectin receptors clrs", "Ca dependent events", "Ca2 pathway", "Calcineurin activates nfat", "Calnexin calreticulin cycle", "Camk iv mediated phosphorylation of creb", "Carboxyterminal post translational modifications of tubulin", "Cardiac conduction", "Cargo concentration in the er", "Cargo recognition for clathrin mediated endocytosis", "Cargo trafficking to the periciliary membrane", "Carnitine metabolism", "Caspase activation via death receptors in the presence of ligand", "Caspase activation via dependence receptors in the absence of ligand", "Caspase activation via extrinsic apoptotic signalling pathway", "Caspase mediated cleavage of cytoskeletal proteins", "Cd163 mediating an anti inflammatory response", "Cd209 dc sign signaling", "Cd28 co stimulation", "Cd28 dependent pi3k akt signaling", "Cd28 dependent vav1 pathway", "Cdc42 gtpase cycle", "Cdc6 association with the orc origin complex", "Cdt1 association with the cdc6 orc origin complex", "Cell cell communication", "Cell cell junction organization", "Cell cycle", "Cell cycle checkpoints", "Cell cycle mitotic", "Cell death signalling via nrage nrif and nade", "Cell extracellular matrix interactions", "Cell junction organization", "Cell surface interactions at the vascular wall", "Cellular hexose transport", "Cellular response to chemical stress", "Cellular response to heat stress", "Cellular response to hypoxia", "Cellular response to starvation", "Cellular responses to stimuli", "Cellular senescence", "Chaperone mediated autophagy", "Chk1 chk2 cds1 mediated inactivation of cyclin b cdk1 complex", "Chl1 interactions", "Cholesterol biosynthesis", "Choline catabolism", "Chondroitin sulfate dermatan sulfate metabolism", "Chrebp activates metabolic gene expression", "Chromatin modifying enzymes", "Chromosome maintenance", "Chylomicron assembly", "Chylomicron clearance", "Cilium assembly", "Circadian clock", "Citric acid cycle tca cycle", "Class a 1 rhodopsin like receptors", "Class b 2 secretin family receptors", "Class i mhc mediated antigen processing presentation", "Class i peroxisomal membrane protein import", "Clathrin mediated endocytosis", "Clec7a dectin 1 induces nfat activation", "Clec7a dectin 1 signaling", "Clec7a inflammasome pathway", "Cobalamin cbl vitamin b12 transport and metabolism", "Coenzyme a biosynthesis", "Cohesin loading onto chromatin", "Collagen biosynthesis and modifying enzymes", "Collagen formation", "Competing endogenous rnas cernas regulate pten translation", "Complement cascade", "Complex i biogenesis", "Condensation of prometaphase chromosomes", "Condensation of prophase chromosomes", "Constitutive signaling by aberrant pi3k in cancer", "Constitutive signaling by akt1 e17k in cancer", "Constitutive signaling by egfrviii", "Constitutive signaling by ligand responsive egfr cancer variants", "Constitutive signaling by overexpressed erbb2", "Conversion from apc c cdc20 to apc c cdh1 in late anaphase", "Cooperation of pdcl phlp1 and tric cct in g protein beta folding", "Cooperation of prefoldin and tric cct in actin and tubulin folding", "Copi dependent golgi to er retrograde traffic", "Copi independent golgi to er retrograde traffic", "Copi mediated anterograde transport", "Copii mediated vesicle transport", "Costimulation by the cd28 family", "Creatine metabolism", "Creb phosphorylation", "Creb1 phosphorylation through nmda receptor mediated activation of ras signaling", "Creb1 phosphorylation through the activation of adenylate cyclase", "Creb1 phosphorylation through the activation of camkii camkk camkiv cascasde", "Cristae formation", "Crmps in sema3a signaling", "Cross presentation of soluble exogenous antigens endosomes", "Cs ds degradation", "Ctla4 inhibitory signaling", "Cyclin a b1 b2 associated events during g2 m transition", "Cyclin a cdk2 associated events at s phase entry", "Cyclin d associated events in g1", "Cytochrome c mediated apoptotic response", "Cytochrome p450 arranged by substrate type", "Cytokine signaling in immune system", "Cytoprotection by hmox1", "Cytosolic iron sulfur cluster assembly", "Cytosolic sensors of pathogen associated dna", "Cytosolic sulfonation of small molecules", "Cytosolic trna aminoacylation", "Dag and ip3 signaling", "Dap12 interactions", "Dap12 signaling", "Darpp 32 events", "Dcc mediated attractive signaling", "Ddx58 ifih1 mediated induction of interferon alpha beta", "Deactivation of the beta catenin transactivating complex", "Deadenylation dependent mrna decay", "Deadenylation of mrna", "Death receptor signalling", "Dectin 1 mediated noncanonical nf kb signaling", "Defective cftr causes cystic fibrosis", "Defective chst14 causes eds musculocontractural type", "Defective factor ix causes hemophilia b", "Defective intrinsic pathway for apoptosis", "Defective ripk1 mediated regulated necrosis", "Defects in biotin btn metabolism", "Defects in cobalamin b12 metabolism", "Defects in vitamin and cofactor metabolism", "Defects of contact activation system cas and kallikrein kinin system kks", "Degradation of axin", "Degradation of beta catenin by the destruction complex", "Degradation of cysteine and homocysteine", "Degradation of dvl", "Degradation of gli1 by the proteasome", "Degradation of the extracellular matrix", "Depolymerisation of the nuclear lamina", "Deposition of new cenpa containing nucleosomes at the centromere", "Dermatan sulfate biosynthesis", "Detoxification of reactive oxygen species", "Deubiquitination", "Developmental biology", "Dex h box helicases activate type i ifn and inflammatory cytokines production", "Digestion", "Digestion and absorption", "Disassembly of the destruction complex and recruitment of axin to the membrane", "Diseases associated with glycosaminoglycan metabolism", "Diseases associated with glycosylation precursor biosynthesis", "Diseases associated with n glycosylation of proteins", "Diseases associated with o glycosylation of proteins", "Diseases of carbohydrate metabolism", "Diseases of dna repair", "Diseases of glycosylation", "Diseases of immune system", "Diseases of metabolism", "Diseases of mismatch repair mmr", "Diseases of mitotic cell cycle", "Diseases of programmed cell death", "Diseases of signal transduction by growth factor receptors and second messengers", "Disinhibition of snare formation", "Disorders of transmembrane transporters", "Displacement of dna glycosylase by apex1", "Dissolution of fibrin clot", "Dna damage bypass", "Dna damage recognition in gg ner", "Dna damage reversal", "Dna damage telomere stress induced senescence", "Dna double strand break repair", "Dna double strand break response", "Dna methylation", "Dna repair", "Dna replication", "Dna replication initiation", "Dna replication pre initiation", "Dna strand elongation", "Dopamine clearance from the synaptic cleft", "Dopamine neurotransmitter release cycle", "Downregulation of erbb2 erbb3 signaling", "Downregulation of erbb2 signaling", "Downregulation of erbb4 signaling", "Downregulation of smad2 3 smad4 transcriptional activity", "Downregulation of tgf beta receptor signaling", "Downstream signal transduction", "Downstream signaling events of b cell receptor bcr", "Downstream signaling of activated fgfr1", "Downstream signaling of activated fgfr2", "Downstream signaling of activated fgfr3", "Downstream signaling of activated fgfr4", "Dscam interactions", "Dual incision in gg ner", "Dual incision in tc ner", "E2f enabled inhibition of pre replication complex formation", "E2f mediated regulation of dna replication", "E3 ubiquitin ligases ubiquitinate target proteins", "Early phase of hiv life cycle", "Ecm proteoglycans", "Effects of pip2 hydrolysis", "Egfr downregulation", "Egfr interacts with phospholipase c gamma", "Egfr transactivation by gastrin", "Egr2 and sox10 mediated initiation of schwann cell myelination", "Elastic fibre formation", "Endogenous sterols", "Endosomal sorting complex required for transport escrt", "Endosomal vacuolar pathway", "Energy dependent regulation of mtor by lkb1 ampk", "Enos activation", "Eph ephrin mediated repulsion of cells", "Eph ephrin signaling", "Epha mediated growth cone collapse", "Ephb mediated forward signaling", "Ephrin signaling", "Epigenetic regulation of gene expression", "Er quality control compartment erqc", "Er to golgi anterograde transport", "Erbb2 regulates cell motility", "Ercc6 csb and ehmt2 g9a positively regulate rrna expression", "Erk mapk targets", "Erks are inactivated", "Erythropoietin activates phospholipase c gamma plcg", "Erythropoietin activates ras", "Esr mediated signaling", "Establishment of sister chromatid cohesion", "Estrogen biosynthesis", "Estrogen dependent gene expression", "Estrogen dependent nuclear events downstream of esr membrane signaling", "Estrogen stimulated signaling through prkcz", "Ethanol oxidation", "Eukaryotic translation elongation", "Eukaryotic translation initiation", "Export of viral ribonucleoproteins from nucleus", "Extension of telomeres", "Extra nuclear estrogen signaling", "Extracellular matrix organization", "Factors involved in megakaryocyte development and platelet production", "Fanconi anemia pathway", "Fasl cd95l signaling", "Fatty acid metabolism", "Fatty acyl coa biosynthesis", "Fbxw7 mutants and notch1 in cancer", "Fc epsilon receptor fceri signaling", "Fceri mediated ca 2 mobilization", "Fceri mediated mapk activation", "Fceri mediated nf kb activation", "Fcgamma receptor fcgr dependent phagocytosis", "Fcgr3a mediated il10 synthesis", "Fgfr1 mutant receptor activation", "Fgfr2 alternative splicing", "Fgfr2 mutant receptor activation", "Fibronectin matrix formation", "Flt3 signaling", "Flt3 signaling in disease", "Folding of actin by cct tric", "Formation of apoptosome", "Formation of atp by chemiosmotic coupling", "Formation of fibrin clot clotting cascade", "Formation of incision complex in gg ner", "Formation of rna pol ii elongation complex", "Formation of senescence associated heterochromatin foci sahf", "Formation of tc ner pre incision complex", "Formation of the beta catenin tcf transactivating complex", "Formation of the cornified envelope", "Formation of the early elongation complex", "Formation of tubulin folding intermediates by cct tric", "Formation of xylulose 5 phosphate", "Formyl peptide receptors bind formyl peptides and many other ligands", "Foxo mediated transcription", "Foxo mediated transcription of oxidative stress metabolic and neuronal genes", "Free fatty acids regulate insulin secretion", "Frs mediated fgfr1 signaling", "Frs mediated fgfr2 signaling", "Frs mediated fgfr3 signaling", "Frs mediated fgfr4 signaling", "Fructose catabolism", "Fructose metabolism", "G alpha 12 13 signalling events", "G alpha i signalling events", "G alpha q signalling events", "G alpha s signalling events", "G alpha z signalling events", "G beta gamma signalling through cdc42", "G beta gamma signalling through pi3kgamma", "G protein beta gamma signalling", "G protein mediated events", "G0 and early g1", "G1 s dna damage checkpoints", "G1 s specific transcription", "G2 m checkpoints", "G2 m dna damage checkpoint", "G2 m dna replication checkpoint", "G2 phase", "Gab1 signalosome", "Gaba b receptor activation", "Gaba receptor activation", "Gaba synthesis release reuptake and degradation", "Galactose catabolism", "Gamma carboxylation hypusine formation and arylsulfatase activation", "Gamma carboxylation transport and amino terminal cleavage of proteins", "Gap filling dna repair synthesis and ligation in gg ner", "Gap junction assembly", "Gap junction degradation", "Gap junction trafficking and regulation", "Gastrin creb signalling pathway via pkc and mapk", "Gdp fucose biosynthesis", "Gene and protein expression by jak stat signaling after interleukin 12 stimulation", "Gene silencing by rna", "Generation of second messenger molecules", "Global genome nucleotide excision repair gg ner", "Glucagon like peptide 1 glp1 regulates insulin secretion", "Glucagon signaling in metabolic regulation", "Gluconeogenesis", "Glucose metabolism", "Glucuronidation", "Glutamate and glutamine metabolism", "Glutamate neurotransmitter release cycle", "Glutathione conjugation", "Glutathione synthesis and recycling", "Glycerophospholipid biosynthesis", "Glycerophospholipid catabolism", "Glycogen breakdown glycogenolysis", "Glycogen metabolism", "Glycogen storage diseases", "Glycogen synthesis", "Glycolysis", "Glycosaminoglycan metabolism", "Glycosphingolipid metabolism", "Glyoxylate metabolism and glycine degradation", "Golgi associated vesicle biogenesis", "Golgi cisternae pericentriolar stack reorganization", "Golgi to er retrograde transport", "Gp1b ix v activation signalling", "Gpcr ligand binding", "Gpvi mediated activation cascade", "Grb2 events in erbb2 signaling", "Grb2 sos provides linkage to mapk signaling for integrins", "Growth hormone receptor signaling", "Hats acetylate histones", "Hcmv early events", "Hcmv infection", "Hcmv late events", "Hdacs deacetylate histones", "Hdl assembly", "Hdl clearance", "Hdms demethylate histones", "Hdr through homologous recombination hrr", "Hdr through mmej alt nhej", "Hdr through single strand annealing ssa", "Hedgehog ligand biogenesis", "Hedgehog off state", "Hedgehog on state", "Heme biosynthesis", "Heme degradation", "Heme signaling", "Hemostasis", "Heparan sulfate heparin hs gag metabolism", "Hiv elongation arrest and recovery", "Hiv infection", "Hiv life cycle", "Hiv transcription elongation", "Hiv transcription initiation", "Homologous dna pairing and strand exchange", "Homology directed repair", "Host interactions of hiv factors", "Hs gag biosynthesis", "Hs gag degradation", "Hsf1 activation", "Hsf1 dependent transactivation", "Hsp90 chaperone cycle for steroid hormone receptors shr in the presence of ligand", "Hur elavl1 binds and stabilizes mrna", "Hyaluronan metabolism", "Hyaluronan uptake and degradation", "Hydrolysis of lpc", "Ikba variant leads to eda id", "Ikk complex recruitment mediated by rip1", "Immunoregulatory interactions between a lymphoid and a non lymphoid cell", "Inactivation of cdc42 and rac1", "Inactivation of csf3 g csf signaling", "Incretin synthesis secretion and inactivation", "Infection with mycobacterium tuberculosis", "Infectious disease", "Inflammasomes", "Influenza infection", "Inhibition of dna recombination at telomere", "Inhibition of replication initiation of damaged dna by rb1 e2f1", "Inhibition of the proteolytic activity of apc c required for the onset of anaphase by mitotic spindle checkpoint components", "Initiation of nuclear envelope ne reformation", "Inla mediated entry of listeria monocytogenes into host cells", "Inlb mediated entry of listeria monocytogenes into host cell", "Innate immune system", "Inositol phosphate metabolism", "Insertion of tail anchored proteins into the endoplasmic reticulum membrane", "Insulin processing", "Insulin receptor recycling", "Insulin receptor signalling cascade", "Integration of energy metabolism", "Integration of provirus", "Integrin cell surface interactions", "Integrin signaling", "Interaction between l1 and ankyrins", "Interactions of rev with host cellular proteins", "Interactions of vpr with host cellular proteins", "Interconversion of nucleotide di and triphosphates", "Interferon alpha beta signaling", "Interferon gamma signaling", "Interferon signaling", "Interleukin 1 family signaling", "Interleukin 1 processing", "Interleukin 1 signaling", "Interleukin 10 signaling", "Interleukin 12 family signaling", "Interleukin 12 signaling", "Interleukin 15 signaling", "Interleukin 17 signaling", "Interleukin 2 family signaling", "Interleukin 20 family signaling", "Interleukin 21 signaling", "Interleukin 23 signaling", "Interleukin 27 signaling", "Interleukin 3 interleukin 5 and gm csf signaling", "Interleukin 35 signalling", "Interleukin 37 signaling", "Interleukin 4 and interleukin 13 signaling", "Interleukin 6 family signaling", "Interleukin 6 signaling", "Interleukin 7 signaling", "Interleukin 9 signaling", "Interleukin receptor shc signaling", "Intra golgi and retrograde golgi to er traffic", "Intra golgi traffic", "Intracellular signaling by second messengers", "Intraflagellar transport", "Intrinsic pathway for apoptosis", "Intrinsic pathway of fibrin clot formation", "Ion channel transport", "Ion homeostasis", "Ion transport by p type atpases", "Ionotropic activity of kainate receptors", "Irak1 recruits ikk complex", "Irak4 deficiency tlr2 4", "Ire1alpha activates chaperones", "Irf3 mediated activation of type 1 ifn", "Irf3 mediated induction of type i ifn", "Iron uptake and transport", "Irs mediated signalling", "Jnk c jun kinases phosphorylation and activation mediated by activated human tak1", "Josephin domain dubs", "Keratan sulfate biosynthesis", "Keratan sulfate degradation", "Keratan sulfate keratin metabolism", "Keratinization", "Ketone body metabolism", "Killing mechanisms", "Kinesins", "Ksrp khsrp binds and destabilizes mrna", "L1cam interactions", "Lagging strand synthesis", "Laminin interactions", "Late endosomal microautophagy", "Ldl clearance", "Ldl remodeling", "Leishmania infection", "Lgi adam interactions", "Linoleic acid la metabolism", "Lipophagy", "Listeria monocytogenes entry into host cells", "Long term potentiation", "Loss of function of mecp2 in rett syndrome", "Loss of mecp2 binding ability to the ncor smrt complex", "Lrr flii interacting protein 1 lrrfip1 activates type i ifn production", "Lysine catabolism", "Lysosome vesicle biogenesis", "M phase", "Map2k and mapk activation", "Map3k8 tpl2 dependent mapk1 3 activation", "Mapk family signaling cascades", "Mapk targets nuclear events mediated by map kinases", "Mapk1 erk2 activation", "Mapk3 erk1 activation", "Mapk6 mapk4 signaling", "Mastl facilitates mitotic progression", "Maturation of sars cov 1 nucleoprotein", "Maturation of sars cov 1 spike protein", "Maturation of sars cov 2 nucleoprotein", "Maturation of sars cov 2 spike protein", "Mecp2 regulates neuronal receptors and channels", "Mecp2 regulates transcription factors", "Mecp2 regulates transcription of neuronal ligands", "Meiosis", "Meiotic recombination", "Meiotic synapsis", "Membrane trafficking", "Met activates pi3k akt signaling", "Met activates ptk2 signaling", "Met activates ptpn11", "Met activates rap1 and rac1", "Met activates ras signaling", "Met interacts with tns proteins", "Met promotes cell motility", "Met receptor activation", "Met receptor recycling", "Metabolic disorders of biological oxidation enzymes", "Metabolism of amino acids and derivatives", "Metabolism of carbohydrates", "Metabolism of cofactors", "Metabolism of fat soluble vitamins", "Metabolism of folate and pterines", "Metabolism of ingested semet sec mesec into h2se", "Metabolism of lipids", "Metabolism of nitric oxide nos3 activation and regulation", "Metabolism of nucleotides", "Metabolism of polyamines", "Metabolism of porphyrins", "Metabolism of rna", "Metabolism of steroid hormones", "Metabolism of steroids", "Metabolism of vitamins and cofactors", "Metabolism of water soluble vitamins and cofactors", "Metalloprotease dubs", "Methionine salvage pathway", "Methylation", "Mhc class ii antigen presentation", "Microrna mirna biogenesis", "Miro gtpase cycle", "Miscellaneous transport and binding events", "Mismatch repair", "Mitochondrial biogenesis", "Mitochondrial calcium ion transport", "Mitochondrial fatty acid beta oxidation", "Mitochondrial fatty acid beta oxidation of saturated fatty acids", "Mitochondrial fatty acid beta oxidation of unsaturated fatty acids", "Mitochondrial iron sulfur cluster biogenesis", "Mitochondrial protein import", "Mitochondrial translation", "Mitochondrial trna aminoacylation", "Mitophagy", "Mitotic g1 phase and g1 s transition", "Mitotic g2 g2 m phases", "Mitotic metaphase and anaphase", "Mitotic prometaphase", "Mitotic prophase", "Mitotic spindle checkpoint", "Mitotic telophase cytokinesis", "Molecules associated with elastic fibres", "Molybdenum cofactor biosynthesis", "Mrna capping", "Mrna decay by 3 to 5 exoribonuclease", "Mrna decay by 5 to 3 exoribonuclease", "Mrna editing", "Mrna splicing", "Mrna splicing minor pathway", "Mtor signalling", "Mtorc1 mediated signalling", "Mucopolysaccharidoses", "Muscle contraction", "Myd88 independent tlr4 cascade", "Myoclonic epilepsy of lafora", "Myogenesis", "N glycan antennae elongation in the medial trans golgi", "N glycan trimming in the er and calnexin calreticulin cycle", "Nade modulates death signalling", "Ncam signaling for neurite out growth", "Neddylation", "Nef and signal transduction", "Nef mediated cd4 down regulation", "Nef mediated cd8 down regulation", "Nef mediated downregulation of mhc class i complex cell surface expression", "Nef mediates down modulation of cell surface receptors by recruiting them to clathrin adapters", "Negative epigenetic regulation of rrna expression", "Negative feedback regulation of mapk pathway", "Negative regulation of fgfr1 signaling", "Negative regulation of fgfr2 signaling", "Negative regulation of fgfr3 signaling", "Negative regulation of fgfr4 signaling", "Negative regulation of flt3", "Negative regulation of mapk pathway", "Negative regulation of met activity", "Negative regulation of nmda receptor mediated neuronal transmission", "Negative regulation of notch4 signaling", "Negative regulation of the pi3k akt network", "Negative regulators of ddx58 ifih1 signaling", "Nephrin family interactions", "Nervous system development", "Netrin 1 signaling", "Neurexins and neuroligins", "Neuronal system", "Neurotoxicity of clostridium toxins", "Neurotransmitter clearance", "Neurotransmitter receptors and postsynaptic signal transmission", "Neurotransmitter release cycle", "Neutrophil degranulation", "Nf kb activation through fadd rip 1 pathway mediated by caspase 8 and 10", "Nf kb is activated and signals survival", "Ngf stimulated transcription", "Nicotinamide salvaging", "Nicotinate metabolism", "Nod1 2 signaling pathway", "Non integrin membrane ecm interactions", "Noncanonical activation of notch3", "Nonhomologous end joining nhej", "Nonsense mediated decay nmd", "Norepinephrine neurotransmitter release cycle", "Nostrin mediated enos trafficking", "Notch hlh transcription pathway", "Notch1 intracellular domain regulates transcription", "Notch2 activation and transmission of signal to the nucleus", "Notch3 activation and transmission of signal to the nucleus", "Notch3 intracellular domain regulates transcription", "Notch4 activation and transmission of signal to the nucleus", "Notch4 intracellular domain regulates transcription", "Nr1h2 and nr1h3 mediated signaling", "Nr1h2 nr1h3 regulate gene expression linked to lipogenesis", "Nr1h3 nr1h2 regulate gene expression linked to cholesterol transport and efflux", "Nrage signals death through jnk", "Nrcam interactions", "Nrif signals cell death from the nucleus", "Ns1 mediated effects on host pathways", "Ntrk2 activates rac1", "Nuclear envelope breakdown", "Nuclear envelope ne reassembly", "Nuclear events kinase and transcription factor activation", "Nuclear events stimulated by alk signaling in cancer", "Nuclear import of rev protein", "Nuclear pore complex npc disassembly", "Nuclear receptor transcription pathway", "Nuclear signaling by erbb4", "Nucleotide binding domain leucine rich repeat containing receptor nlr signaling pathways", "Nucleotide biosynthesis", "Nucleotide catabolism", "Nucleotide excision repair", "Nucleotide salvage", "O linked glycosylation", "O linked glycosylation of mucins", "Oas antiviral response", "Oncogene induced senescence", "Oncogenic mapk signaling", "Opioid signalling", "Orc1 removal from chromatin", "Organelle biogenesis and maintenance", "Organic anion transporters", "Other interleukin signaling", "Other semaphorin interactions", "Ovarian tumor domain proteases", "Oxidative stress induced senescence", "P130cas linkage to mapk signaling for integrins", "P38mapk events", "P75 ntr receptor mediated signalling", "P75ntr negatively regulates cell cycle via sc1", "P75ntr recruits signalling complexes", "P75ntr regulates axonogenesis", "P75ntr signals via nf kb", "Parasite infection", "Passive transport by aquaporins", "Pcna dependent long patch base excision repair", "Pcp ce pathway", "Pd 1 signaling", "Pecam1 interactions", "Pentose phosphate pathway", "Peptide hormone metabolism", "Peptide ligand binding receptors", "Perk regulates gene expression", "Peroxisomal lipid metabolism", "Peroxisomal protein import", "Pexophagy", "Phase 0 rapid depolarisation", "Phase i functionalization of compounds", "Phase ii conjugation of compounds", "Phenylalanine and tyrosine metabolism", "Phenylalanine metabolism", "Phosphate bond hydrolysis by nudt proteins", "Phospholipase c mediated cascade fgfr2", "Phospholipase c mediated cascade fgfr4", "Phospholipid metabolism", "Phosphorylation of emi1", "Phosphorylation of the apc c", "Pi 3k cascade fgfr1", "Pi 3k cascade fgfr2", "Pi 3k cascade fgfr3", "Pi 3k cascade fgfr4", "Pi metabolism", "Pi3k akt activation", "Pi3k akt signaling in cancer", "Pi3k events in erbb2 signaling", "Pi5p regulates tp53 acetylation", "Pink1 prkn mediated mitophagy", "Piwi interacting rna pirna biogenesis", "Pka activation in glucagon signalling", "Pka mediated phosphorylation of creb", "Pka mediated phosphorylation of key metabolic factors", "Pkmts methylate histone lysines", "Plasma lipoprotein assembly", "Plasma lipoprotein assembly remodeling and clearance", "Plasma lipoprotein clearance", "Plasma lipoprotein remodeling", "Platelet activation signaling and aggregation", "Platelet adhesion to exposed collagen", "Platelet aggregation plug formation", "Platelet calcium homeostasis", "Platelet homeostasis", "Platelet sensitization by ldl", "Polb dependent long patch base excision repair", "Polo like kinase mediated events", "Polymerase switching", "Polymerase switching on the c strand of the telomere", "Positive epigenetic regulation of rrna expression", "Post chaperonin tubulin folding pathway", "Post translational modification synthesis of gpi anchored proteins", "Post translational protein modification", "Postmitotic nuclear pore complex npc reformation", "Potential therapeutics for sars", "Pou5f1 oct4 sox2 nanog activate genes related to proliferation", "Pou5f1 oct4 sox2 nanog repress genes related to differentiation", "Pp2a mediated dephosphorylation of key metabolic factors", "Prc2 methylates histones and dna", "Pre notch expression and processing", "Pre notch processing in golgi", "Pre notch processing in the endoplasmic reticulum", "Pregnenolone biosynthesis", "Prevention of phagosomal lysosomal fusion", "Processing and activation of sumo", "Processing of capped intron containing pre mrna", "Processing of capped intronless pre mrna", "Processing of dna double strand break ends", "Processing of intronless pre mrnas", "Processing of smdt1", "Processive synthesis on the c strand of the telomere", "Processive synthesis on the lagging strand", "Programmed cell death", "Prolactin receptor signaling", "Prolonged erk activation events", "Propionyl coa catabolism", "Protein folding", "Protein localization", "Protein methylation", "Protein protein interactions at synapses", "Protein repair", "Protein ubiquitination", "Proton coupled monocarboxylate transport", "Pten regulation", "Ptk6 expression", "Ptk6 regulates cell cycle", "Ptk6 regulates proteins involved in rna processing", "Ptk6 regulates rho gtpases ras gtpase and map kinases", "Purine catabolism", "Purine ribonucleoside monophosphate biosynthesis", "Purine salvage", "Purinergic signaling in leishmaniasis infection", "Pyrimidine salvage", "Pyroptosis", "Pyruvate metabolism", "Pyruvate metabolism and citric acid tca cycle", "Ra biosynthesis pathway", "Rab gefs exchange gtp for gdp on rabs", "Rab geranylgeranylation", "Rab regulation of trafficking", "Rac1 gtpase cycle", "Rac2 gtpase cycle", "Rac3 gtpase cycle", "Raf activation", "Raf independent mapk1 3 activation", "Rap1 signalling", "Ras activation upon ca2 influx through nmda receptor", "Ras processing", "Reactions specific to the complex n glycan synthesis pathway", "Receptor mediated mitophagy", "Receptor type tyrosine protein phosphatases", "Recognition and association of dna glycosylase with site containing an affected purine", "Recognition of dna damage by pcna containing replication complex", "Recruitment of mitotic centrosome proteins and complexes", "Recruitment of numa to mitotic centrosomes", "Recycling of eif2 gdp", "Recycling pathway of l1", "Reduction of cytosolic ca levels", "Regulated necrosis", "Regulated proteolysis of p75ntr", "Regulation by c flip", "Regulation of bach1 activity", "Regulation of beta cell development", "Regulation of cholesterol biosynthesis by srebp srebf", "Regulation of commissural axon pathfinding by slit and robo", "Regulation of cytoskeletal remodeling and cell spreading by ipp complex components", "Regulation of expression of slits and robos", "Regulation of foxo transcriptional activity by acetylation", "Regulation of gene expression in beta cells", "Regulation of gene expression in late stage branching morphogenesis pancreatic bud precursor cells", "Regulation of glucokinase by glucokinase regulatory protein", "Regulation of glycolysis by fructose 2 6 bisphosphate metabolism", "Regulation of hmox1 expression and activity", "Regulation of hsf1 mediated heat shock response", "Regulation of ifna signaling", "Regulation of ifng signaling", "Regulation of innate immune responses to cytosolic dna", "Regulation of insulin like growth factor igf transport and uptake by insulin like growth factor binding proteins igfbps", "Regulation of insulin secretion", "Regulation of kit signaling", "Regulation of lipid metabolism by pparalpha", "Regulation of localization of foxo transcription factors", "Regulation of mecp2 expression and activity", "Regulation of mrna stability by proteins that bind au rich elements", "Regulation of plk1 activity at g2 m transition", "Regulation of pten gene transcription", "Regulation of pten localization", "Regulation of pten mrna translation", "Regulation of pten stability and activity", "Regulation of pyruvate dehydrogenase pdh complex", "Regulation of ras by gaps", "Regulation of runx1 expression and activity", "Regulation of runx2 expression and activity", "Regulation of runx3 expression and activity", "Regulation of signaling by cbl", "Regulation of tlr by endogenous ligand", "Regulation of tnfr1 signaling", "Regulation of tp53 activity", "Regulation of tp53 activity through acetylation", "Regulation of tp53 activity through association with co factors", "Regulation of tp53 activity through methylation", "Regulation of tp53 activity through phosphorylation", "Regulation of tp53 expression and degradation", "Release of apoptotic factors from the mitochondria", "Repression of wnt target genes", "Reproduction", "Resolution of abasic sites ap sites", "Resolution of ap sites via the multiple nucleotide patch replacement pathway", "Resolution of d loop structures", "Resolution of d loop structures through synthesis dependent strand annealing sdsa", "Resolution of sister chromatid cohesion", "Respiratory electron transport", "Respiratory electron transport atp synthesis by chemiosmotic coupling and heat production by uncoupling proteins", "Response of eif2ak1 hri to heme deficiency", "Response of eif2ak4 gcn2 to amino acid deficiency", "Response of mtb to phagocytosis", "Response to elevated platelet cytosolic ca2", "Ret signaling", "Retrograde neurotrophin signalling", "Retrograde transport at the trans golgi network", "Rho gtpase cycle", "Rho gtpase effectors", "Rho gtpases activate cit", "Rho gtpases activate formins", "Rho gtpases activate iqgaps", "Rho gtpases activate ktn1", "Rho gtpases activate nadph oxidases", "Rho gtpases activate paks", "Rho gtpases activate pkns", "Rho gtpases activate rhotekin and rhophilins", "Rho gtpases activate rocks", "Rho gtpases activate wasps and waves", "Rhoa gtpase cycle", "Rhob gtpase cycle", "Rhobtb gtpase cycle", "Rhobtb1 gtpase cycle", "Rhobtb2 gtpase cycle", "Rhobtb3 atpase cycle", "Rhoc gtpase cycle", "Rhod gtpase cycle", "Rhof gtpase cycle", "Rhog gtpase cycle", "Rhoh gtpase cycle", "Rhoj gtpase cycle", "Rhoq gtpase cycle", "Rhot1 gtpase cycle", "Rhou gtpase cycle", "Rhov gtpase cycle", "Rip mediated nfkb activation via zbp1", "Ripk1 mediated regulated necrosis", "Rmts methylate histone arginines", "Rna polymerase i promoter escape", "Rna polymerase i transcription", "Rna polymerase i transcription initiation", "Rna polymerase i transcription termination", "Rna polymerase ii transcribes snrna genes", "Rna polymerase ii transcription", "Rna polymerase ii transcription termination", "Rna polymerase iii chain elongation", "Rna polymerase iii transcription", "Rna polymerase iii transcription initiation from type 1 promoter", "Rna polymerase iii transcription initiation from type 3 promoter", "Rna polymerase iii transcription termination", "Rnd1 gtpase cycle", "Rnd2 gtpase cycle", "Rnd3 gtpase cycle", "Robo receptors bind akap5", "Role of abl in robo slit signaling", "Role of lat2 ntal lab on calcium mobilization", "Role of phospholipids in phagocytosis", "Role of second messengers in netrin 1 signaling", "Rora activates gene expression", "Ros and rns production in phagocytes", "Rrna modification in the nucleus and cytosol", "Rrna processing", "Rrna processing in the mitochondrion", "Rsk activation", "Runx1 interacts with co factors whose precise effect on runx1 targets is not known", "Runx1 regulates estrogen receptor mediated transcription", "Runx1 regulates expression of components of tight junctions", "Runx1 regulates genes involved in megakaryocyte differentiation and platelet function", "Runx1 regulates transcription of genes involved in differentiation of hscs", "Runx1 regulates transcription of genes involved in differentiation of myeloid cells", "Runx2 regulates bone development", "Runx2 regulates genes involved in cell migration", "Runx2 regulates osteoblast differentiation", "Runx3 regulates cdkn1a transcription", "Runx3 regulates notch signaling", "Runx3 regulates wnt signaling", "S phase", "Sars cov 1 infection", "Sars cov 2 infection", "Sars cov infections", "Scavenging by class a receptors", "Scavenging by class b receptors", "Scavenging by class f receptors", "Scf skp2 mediated degradation of p27 p21", "Sealing of the nuclear envelope ne by escrt iii", "Selective autophagy", "Selenoamino acid metabolism", "Sema3a pak dependent axon repulsion", "Sema3a plexin repulsion signaling by inhibiting integrin adhesion", "Sema4d in semaphorin signaling", "Sema4d induced cell migration and growth cone collapse", "Sema4d mediated inhibition of cell attachment and migration", "Semaphorin interactions", "Senescence associated secretory phenotype sasp", "Sensing of dna double strand breaks", "Sensory perception", "Sensory processing of sound", "Sensory processing of sound by outer hair cells of the cochlea", "Separation of sister chromatids", "Serine biosynthesis", "Serotonin neurotransmitter release cycle", "Shc mediated cascade fgfr1", "Shc mediated cascade fgfr3", "Shc mediated cascade fgfr4", "Shc related events triggered by igf1r", "Shc1 events in egfr signaling", "Shc1 events in erbb2 signaling", "Shc1 events in erbb4 signaling", "Sialic acid metabolism", "Signal amplification", "Signal attenuation", "Signal regulatory protein family interactions", "Signal transduction by l1", "Signaling by activin", "Signaling by alk", "Signaling by alk in cancer", "Signaling by bmp", "Signaling by braf and raf1 fusions", "Signaling by csf3 g csf", "Signaling by ctnnb1 phospho site mutants", "Signaling by cytosolic fgfr1 fusion mutants", "Signaling by egfr", "Signaling by egfr in cancer", "Signaling by erbb2", "Signaling by erbb2 ecd mutants", "Signaling by erbb2 in cancer", "Signaling by erbb4", "Signaling by erythropoietin", "Signaling by fgfr", "Signaling by fgfr in disease", "Signaling by fgfr1", "Signaling by fgfr1 in disease", "Signaling by fgfr2", "Signaling by fgfr2 iiia tm", "Signaling by fgfr2 in disease", "Signaling by fgfr3", "Signaling by fgfr3 fusions in cancer", "Signaling by fgfr4", "Signaling by fgfr4 in disease", "Signaling by flt3 fusion proteins", "Signaling by flt3 itd and tkd mutants", "Signaling by gpcr", "Signaling by hedgehog", "Signaling by hippo", "Signaling by insulin receptor", "Signaling by interleukins", "Signaling by kit in disease", "Signaling by leptin", "Signaling by mapk mutants", "Signaling by met", "Signaling by moderate kinase activity braf mutants", "Signaling by mras complex mutants", "Signaling by mst1", "Signaling by nodal", "Signaling by notch", "Signaling by notch1", "Signaling by notch1 pest domain mutants in cancer", "Signaling by notch2", "Signaling by notch3", "Signaling by notch4", "Signaling by ntrk2 trkb", "Signaling by ntrk3 trkc", "Signaling by ntrks", "Signaling by nuclear receptors", "Signaling by pdgf", "Signaling by pdgfr in disease", "Signaling by pdgfra transmembrane juxtamembrane and kinase domain mutants", "Signaling by ptk6", "Signaling by receptor tyrosine kinases", "Signaling by retinoic acid", "Signaling by rho gtpases miro gtpases and rhobtb3", "Signaling by robo receptors", "Signaling by scf kit", "Signaling by tgf beta receptor complex", "Signaling by tgf beta receptor complex in cancer", "Signaling by tgfb family members", "Signaling by the b cell receptor bcr", "Signaling by type 1 insulin like growth factor 1 receptor igf1r", "Signaling by vegf", "Signaling by wnt", "Signaling by wnt in cancer", "Signalling to erks", "Signalling to ras", "Sirt1 negatively regulates rrna expression", "Slbp dependent processing of replication dependent histone pre mrnas", "Slc mediated transmembrane transport", "Slc transporter disorders", "Smac xiap regulated apoptotic response", "Smad2 smad3 smad4 heterotrimer regulates transcription", "Small interfering rna sirna biogenesis", "Smooth muscle contraction", "Snrnp assembly", "Sodium calcium exchangers", "Sos mediated signalling", "Sphingolipid de novo biosynthesis", "Sphingolipid metabolism", "Spry regulation of fgf signaling", "Srp dependent cotranslational protein targeting to membrane", "Stabilization of p53", "Stat3 nuclear events downstream of alk signaling", "Stat5 activation", "Stat5 activation downstream of flt3 itd mutants", "Stimuli sensing channels", "Sting mediated induction of host immune responses", "Striated muscle contraction", "Sulfide oxidation to sulfate", "Sulfur amino acid metabolism", "Sumo is conjugated to e1 uba2 sae1", "Sumo is transferred from e1 to e2 ube2i ubc9", "Sumoylation", "Sumoylation of chromatin organization proteins", "Sumoylation of dna damage response and repair proteins", "Sumoylation of dna methylation proteins", "Sumoylation of dna replication proteins", "Sumoylation of rna binding proteins", "Sumoylation of sumoylation proteins", "Sumoylation of transcription cofactors", "Sumoylation of transcription factors", "Sumoylation of ubiquitinylation proteins", "Suppression of apoptosis", "Suppression of phagosomal maturation", "Surfactant metabolism", "Switching of origins to a post replicative state", "Synaptic adhesion like molecules", "Syndecan interactions", "Synthesis of 5 eicosatetraenoic acids", "Synthesis of active ubiquitin roles of e1 and e2 enzymes", "Synthesis of bile acids and bile salts", "Synthesis of bile acids and bile salts via 7alpha hydroxycholesterol", "Synthesis of diphthamide eef2", "Synthesis of dna", "Synthesis of dolichyl phosphate", "Synthesis of epoxy eet and dihydroxyeicosatrienoic acids dhet", "Synthesis of gdp mannose", "Synthesis of ip2 ip and ins in the cytosol", "Synthesis of ip3 and ip4 in the cytosol", "Synthesis of ketone bodies", "Synthesis of leukotrienes lt and eoxins ex", "Synthesis of lipoxins lx", "Synthesis of pa", "Synthesis of pc", "Synthesis of pe", "Synthesis of pg", "Synthesis of pi", "Synthesis of pips at the early endosome membrane", "Synthesis of pips at the er membrane", "Synthesis of pips at the golgi membrane", "Synthesis of pips at the late endosome membrane", "Synthesis of pips at the plasma membrane", "Synthesis of prostaglandins pg and thromboxanes tx", "Synthesis of pyrophosphates in the cytosol", "Synthesis of substrates in n glycan biosythesis", "Synthesis of udp n acetyl glucosamine", "Synthesis of very long chain fatty acyl coas", "Synthesis secretion and deacylation of ghrelin", "Synthesis secretion and inactivation of glucagon like peptide 1 glp 1", "Synthesis secretion and inactivation of glucose dependent insulinotropic polypeptide gip", "Tak1 activates nfkb by phosphorylation and activation of ikks complex", "Tbc rabgaps", "Tcf dependent signaling in response to wnt", "Tcr signaling", "Telomere c strand lagging strand synthesis", "Telomere c strand synthesis initiation", "Telomere extension by telomerase", "Telomere maintenance", "Termination of translesion dna synthesis", "Tetrahydrobiopterin bh4 synthesis recycling salvage and regulation", "Tfap2a acts as a transcriptional repressor during retinoic acid induced cell differentiation", "Tgf beta receptor signaling activates smads", "Tgf beta receptor signaling in emt epithelial to mesenchymal transition", "The activation of arylsulfatases", "The canonical retinoid cycle in rods twilight vision", "The citric acid tca cycle and respiratory electron transport", "The nlrp3 inflammasome", "The phototransduction cascade", "The role of gtse1 in g2 m progression after g2 checkpoint", "The role of nef in hiv 1 replication and disease pathogenesis", "Thrombin signalling through proteinase activated receptors pars", "Thromboxane signalling through tp receptor", "Ticam1 rip1 mediated ikk complex recruitment", "Tie2 signaling", "Tight junction interactions", "Tlr3 mediated ticam1 dependent programmed cell death", "Tnf signaling", "Tnfr1 induced nfkappab signaling pathway", "Tnfr1 induced proapoptotic signaling", "Tnfr1 mediated ceramide production", "Tnfr2 non canonical nf kb pathway", "Toll like receptor 9 tlr9 cascade", "Toll like receptor cascades", "Toll like receptor tlr1 tlr2 cascade", "Toxicity of botulinum toxin type d botd", "Tp53 regulates metabolic genes", "Tp53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "Tp53 regulates transcription of caspase activators and caspases", "Tp53 regulates transcription of cell cycle genes", "Tp53 regulates transcription of cell death genes", "Tp53 regulates transcription of death receptors and ligands", "Tp53 regulates transcription of dna repair genes", "Tp53 regulates transcription of genes involved in cytochrome c release", "Tp53 regulates transcription of genes involved in g1 cell cycle arrest", "Tp53 regulates transcription of genes involved in g2 cell cycle arrest", "Tp53 regulates transcription of several additional cell death genes whose specific roles in p53 dependent apoptosis remain uncertain", "Traf3 dependent irf activation pathway", "Traf6 mediated irf7 activation", "Traf6 mediated irf7 activation in tlr7 8 or 9 signaling", "Traf6 mediated nf kb activation", "Trafficking and processing of endosomal tlr", "Trafficking of ampa receptors", "Trafficking of glur2 containing ampa receptors", "Trafficking of myristoylated proteins to the cilium", "Trail signaling", "Trans golgi network vesicle budding", "Transcription coupled nucleotide excision repair tc ner", "Transcription of e2f targets under negative control by dream complex", "Transcription of e2f targets under negative control by p107 rbl1 and p130 rbl2 in complex with hdac1", "Transcription of the hiv genome", "Transcriptional activation of mitochondrial biogenesis", "Transcriptional activity of smad2 smad3 smad4 heterotrimer", "Transcriptional regulation by e2f6", "Transcriptional regulation by mecp2", "Transcriptional regulation by runx1", "Transcriptional regulation by runx2", "Transcriptional regulation by runx3", "Transcriptional regulation by small rnas", "Transcriptional regulation by the ap 2 tfap2 family of transcription factors", "Transcriptional regulation by tp53", "Transcriptional regulation by ventx", "Transcriptional regulation of granulopoiesis", "Transcriptional regulation of pluripotent stem cells", "Transcriptional regulation of white adipocyte differentiation", "Transferrin endocytosis and recycling", "Translation", "Translation of replicase and assembly of the replication transcription complex", "Translation of sars cov 1 structural proteins", "Translation of sars cov 2 structural proteins", "Translesion synthesis by polh", "Translesion synthesis by polk", "Translesion synthesis by y family dna polymerases bypasses lesions on dna template", "Translocation of slc2a4 glut4 to the plasma membrane", "Transmission across chemical synapses", "Transport and synthesis of paps", "Transport of bile salts and organic acids metal ions and amine compounds", "Transport of connexons to the plasma membrane", "Transport of fatty acids", "Transport of inorganic cations anions and amino acids oligopeptides", "Transport of mature mrnas derived from intronless transcripts", "Transport of mature transcript to cytoplasm", "Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane", "Transport of nucleotide sugars", "Transport of small molecules", "Transport of the slbp dependant mature mrna", "Transport of vitamins nucleosides and related molecules", "Transport to the golgi and subsequent modification", "Trif mediated programmed cell death", "Triglyceride biosynthesis", "Triglyceride catabolism", "Triglyceride metabolism", "Tristetraprolin ttp zfp36 binds and destabilizes mrna", "Trna aminoacylation", "Trna modification in the mitochondrion", "Trna modification in the nucleus and cytosol", "Trna processing", "Trna processing in the mitochondrion", "Trna processing in the nucleus", "Trp channels", "Tryptophan catabolism", "Type i hemidesmosome assembly", "Tyrosine catabolism", "Tysnd1 cleaves peroxisomal proteins", "Ub specific processing proteases", "Ubiquinol biosynthesis", "Uch proteinases", "Unblocking of nmda receptors glutamate binding and activation", "Unfolded protein response upr", "Unwinding of dna", "Uptake and actions of bacterial toxins", "Uptake and function of anthrax toxins", "Uptake and function of diphtheria toxin", "Urea cycle", "Vasopressin regulates renal water homeostasis via aquaporins", "Vegfr2 mediated cell proliferation", "Vegfr2 mediated vascular permeability", "Vesicle mediated transport", "Viral messenger rna synthesis", "Visual phototransduction", "Vitamin b2 riboflavin metabolism", "Vitamin b5 pantothenate metabolism", "Vitamin c ascorbate metabolism", "Vitamin d calciferol metabolism", "Vldl assembly", "Vldlr internalisation and degradation", "Vxpx cargo targeting to cilium", "Wax and plasmalogen biosynthesis", "Wnt ligand biogenesis and trafficking", "Wnt mediated activation of dvl", "Wnt5a dependent internalization of fzd2 fzd5 and ror2", "Wnt5a dependent internalization of fzd4", "Zbp1 dai mediated induction of type i ifns"], "available_proteins": ["AAAS", "AARS", "AARS2", "AASDHPPT", "AASS", "AATF", "ABCB1", "ABCB10", "ABCB7", "ABCD3", "ABCE1", "ABCF1", "ABHD10", "ABHD12", "ABHD14B", "ABHD6", "ACAA2", "ACACA", "ACACB", "ACAD9", "ACADM", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACBD5", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT8", "ACOT9", "ACOX1", "ACOX3", "ACP6", "ACSL1", "ACSL3", "ACSL4", "ACTN1", "ACTN2", "ACTN4", "ACTR10", "ACTR1A", "ACTR2", "ACTR3", "ADA", "ADAR", "ADD1", "ADD3", "ADH5", "ADI1", "ADK", "ADPGK", "ADPRHL2", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGK", "AGL", "AGPAT1", "AGPS", "AHCTF1", "AHCY", "AHCYL1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AK4", "AK6", "AKAP12", "AKAP13", "AKR1A1", "AKR1B1", "AKR7A2", "AKT2", "ALDH18A1", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALG1", "ALKBH5", "ALYREF", "AMOT", "ANAPC1", "ANAPC16", "ANAPC4", "ANAPC5", "ANAPC7", "ANK3", "ANKFY1", "ANKLE2", "ANLN", "ANP32A", "ANXA1", "ANXA2", "ANXA6", "AP1B1", "AP1G1", "AP1M1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3M1", "APC", "APEH", "APEX1", "APOOL", "APP", "APPL1", "APRT", "AQR", "ARCN1", "ARF4", "ARF5", "ARFGAP1", "ARFIP2", "ARHGAP17", "ARHGDIA", "ARHGEF1", "ARHGEF2", "ARID1A", "ARIH1", "ARL1", "ARL2", "ARL3", "ARL6IP5", "ARMC8", "ARMCX3", "ARPC1A", "ARPC2", "ARPC3", "ARPC4", "ARPC5", "ASAH1", "ASCC3", "ASF1A", "ASNA1", "ASNS", "ASPH", "ATAD1", "ATAD3B", "ATG7", "ATIC", "ATP13A1", "ATP1A1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5L", "ATP5O", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1D", "ATP6V1E1", "ATP6V1H", "AURKA", "B3GALT6", "B4GAT1", "BABAM1", "BAG2", "BAG4", "BAG5", "BAG6", "BAIAP2", "BAK1", "BANF1", "BASP1", "BAZ1B", "BCAP31", "BCAS2", "BCS1L", "BDH2", "BICD2", "BIRC6", "BLMH", "BLVRA", "BLVRB", "BMS1", "BNIP1", "BOP1", "BPNT1", "BRD4", "BSG", "BUB1", "BUB1B", "BUB3", "BUD31", "BYSL", "C19orf70", "C1QBP", "C1orf35", "CAD", "CALD1", "CALR", "CALU", "CAMK2G", "CAND1", "CANX", "CAP1", "CAPN1", "CAPNS1", "CAPZA1", "CAPZB", "CARM1", "CARS", "CARS2", "CASK", "CASP3", "CASP6", "CASP7", "CASP8", "CAST", "CBR1", "CBX1", "CBX3", "CBX5", "CBX8", "CCAR1", "CCAR2", "CCDC22", "CCNB1", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2AP", "CD2BP2", "CD3EAP", "CD47", "CDC16", "CDC23", "CDC27", "CDC37", "CDC40", "CDC42", "CDC45", "CDC5L", "CDC73", "CDCA5", "CDIPT", "CDK1", "CDK12", "CDK2", "CDK4", "CDK6", "CDS2", "CDX2", "CERS1", "CERS2", "CETN2", "CFL1", "CHAC2", "CHAF1B", "CHAMP1", "CHCHD3", "CHD1", "CHD4", "CHEK2", "CHERP", "CHID1", "CHKA", "CHML", "CHMP1A", "CHMP2B", "CHMP5", "CHMP6", "CHMP7", "CHORDC1", "CHST14", "CIAPIN1", "CKAP4", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLCN3", "CLINT1", "CLNS1A", "CLTA", "CLTC", "CMPK1", "CNDP2", "CNN2", "CNOT1", "CNOT7", "CNOT9", "COASY", "COG2", "COG6", "COLEC12", "COLGALT1", "COMMD4", "COMT", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS7A", "COPS7B", "COPS8", "COPZ1", "COQ9", "COTL1", "COX15", "COX2", "COX4I1", "COX5A", "COX5B", "COX6C", "COX7C", "CPD", "CPNE1", "CPNE3", "CPOX", "CPPED1", "CPSF1", "CPSF2", "CPSF3", "CPSF6", "CPSF7", "CPT1A", "CPT2", "CRKL", "CRMP1", "CRNKL1", "CRTAP", "CS", "CSK", "CSNK1A1", "CSNK2A2", "CSNK2B", "CSTB", "CSTF1", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTPS2", "CTR9", "CTSA", "CTSC", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4A", "CUL4B", "CUL5", "CYB5B", "CYB5R3", "CYC1", "CYFIP1", "CYP51A1", "DAD1", "DAGLB", "DAP3", "DARS", "DARS2", "DBN1", "DBNL", "DCAF1", "DCAF13", "DCAF7", "DCD", "DCP1A", "DCPS", "DCTD", "DCTN1", "DCTN2", "DCTN3", "DCTN4", "DCTN6", "DCTPP1", "DCUN1D4", "DCUN1D5", "DCXR", "DDAH1", "DDB1", "DDOST", "DDRGK1", "DDX1", "DDX17", "DDX20", "DDX21", "DDX23", "DDX39A", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX52", "DDX56", "DDX6", "DEK", "DERL1", "DFFA", "DHCR24", "DHCR7", "DHFR", "DHPS", "DHRS7B", "DHX15", "DHX16", "DHX36", "DHX37", "DHX38", "DHX9", "DIABLO", "DIAPH1", "DIAPH3", "DICER1", "DIDO1", "DIEXF", "DIS3", "DKC1", "DLAT", "DLD", "DLST", "DNAJA1", "DNAJA2", "DNAJB1", "DNAJC11", "DNAJC2", "DNAJC3", "DNAJC7", "DNAJC8", "DNM1L", "DNM2", "DNMT1", "DNPH1", "DOCK7", "DOHH", "DOLPP1", "DPH2", "DPH5", "DPYSL2", "DPYSL3", "DSG2", "DSP", "DST", "DTL", "DTYMK", "DUSP3", "DUSP9", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNLL1", "DYNLL2", "EARS2", "EBNA1BP2", "EBP", "ECE1", "ECH1", "ECHS1", "ECI1", "ECI2", "ECSIT", "EDC3", "EDC4", "EEA1", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EEFSEC", "EFTUD2", "EHD1", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAC2", "ELAVL1", "ELOB", "ELOC", "ELP1", "ELP2", "ELP3", "EMC3", "EMD", "EMG1", "EML4", "ENAH", "ENDOD1", "ENO1", "ENSA", "EPB41", "EPB41L2", "EPB41L3", "EPHX1", "EPHX2", "EPRS", "EPS15", "EPS15L1", "ERAL1", "ERAP1", "ERCC2", "ERCC3", "ERLIN1", "ERLIN2", "ERO1A", "ERP44", "ESD", "ESYT1", "ESYT2", "ETF1", "ETFA", "ETFB", "ETFDH", "EXO1", "EXOC1", "EXOC2", "EXOC4", "EXOC5", "EXOC7", "EXOSC10", "EXOSC3", "EXOSC4", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC8", "EZR", "F11R", "FABP5", "FADS2", "FAF2", "FAH", "FAHD1", "FAM114A2", "FAM3C", "FAM49B", "FAM91A1", "FAM98B", "FANCI", "FAR1", "FARSA", "FARSB", "FASN", "FAU", "FBL", "FBXO22", "FBXO7", "FDFT1", "FDPS", "FDX1", "FDXR", "FECH", "FEN1", "FERMT2", "FGFR1OP", "FH", "FIP1L1", "FIS1", "FKBP14", "FKBP1A", "FKBP4", "FKBP5", "FKBP8", "FLAD1", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FN3KRP", "FNTB", "FSCN1", "FTO", "FTSJ1", "FTSJ3", "FUCA1", "FUCA2", "FUS", "FXR1", "G6PD", "GAA", "GABARAPL2", "GADD45GIP1", "GALK1", "GALNT2", "GALNT7", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GATAD2B", "GBA", "GBE1", "GBF1", "GCAT", "GCC2", "GCDH", "GCLM", "GCN1", "GDAP1", "GDI1", "GDI2", "GDPD1", "GEMIN4", "GEMIN5", "GET4", "GFM1", "GFPT1", "GGA1", "GGCT", "GGCX", "GGH", "GHDC", "GINS2", "GINS3", "GINS4", "GLA", "GLB1", "GLDC", "GLG1", "GLMN", "GLO1", "GLRX3", "GLRX5", "GLS", "GLUD1", "GM2A", "GMDS", "GMPPA", "GMPPB", "GMPS", "GNA13", "GNAI1", "GNAI2", "GNAI3", "GNL3", "GNPDA1", "GNS", "GOLGA3", "GOLGB1", "GOLIM4", "GORASP2", "GOT1", "GOT2", "GPAM", "GPD2", "GPHN", "GPI", "GPKOW", "GPS1", "GPT2", "GPX8", "GRB2", "GRHPR", "GRPEL1", "GRSF1", "GSK3A", "GSK3B", "GSPT1", "GSR", "GSS", "GSTK1", "GSTM3", "GSTO1", "GSTZ1", "GTF2B", "GTF2E1", "GTF2F1", "GTF2F2", "GTF3C1", "GTF3C2", "GTF3C3", "GTPBP3", "GUSB", "GYG1", "H1F0", "H2AFX", "H4C1*", "HACD3", "HADH", "HADHA", "HADHB", "HAT1", "HAUS4", "HAUS5", "HBS1L", "HCFC1", "HDAC2", "HDGF", "HDLBP", "HEATR1", "HEBP1", "HECTD1", "HEXA", "HEXB", "HGS", "HIBADH", "HIBCH", "HINT2", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HLTF", "HM13", "HMBS", "HMGA1", "HMGB1", "HMGB2", "HMGCL", "HMGCS1", "HMOX1", "HMOX2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPK", "HNRNPL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HPRT1", "HS2ST1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA14", "HSPA1B", "HSPA2", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPB1", "HSPD1", "HSPE1", "HSPH1", "HTT", "HUS1", "HUWE1", "HYOU1", "IARS", "IARS2", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDI1", "IFIT5", "IFT27", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "ILF2", "ILK", "IMMT", "IMP3", "IMPDH1", "IMPDH2", "INTS13", "INTS14", "INTS3", "INTS7", "IPO5", "IPO8", "IPO9", "IQGAP1", "IRS4", "IST1", "ISYNA1", "ITCH", "ITGB1", "ITPA", "IVD", "IWS1", "JUP", "KARS", "KAT7", "KDELR1", "KDM1A", "KDM1B", "KDM2A", "KDM3B", "KDSR", "KHDRBS1", "KHDRBS3", "KHSRP", "KIF11", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF3A", "KIF4A", "KIF5B", "KIFC1", "KLC1", "KLC2", "KLC4", "KPNA1", "KPNA2", "KPNA3", "KPNA6", "KPNB1", "KTN1", "KYAT3", "L2HGDH", "LAMP1", "LAMP2", "LAMTOR1", "LARS", "LARS2", "LAS1L", "LBR", "LDHA", "LDHB", "LDLR", "LEMD2", "LEMD3", "LETM1", "LGALS3", "LGALS3BP", "LGMN", "LIG1", "LIG3", "LIPA", "LLGL1", "LMAN1", "LMAN2", "LMNA", "LMNB1", "LNPEP", "LPCAT1", "LRPPRC", "LSM6", "LSM7", "LSM8", "LSS", "LTA4H", "LTV1", "LYPLA1", "LZTFL1", "M6PR", "MAD1L1", "MAD2L1", "MAGED2", "MAGT1", "MAIP1", "MAP2K1", "MAP2K2", "MAP2K3", "MAPK1", "MAPK14", "MAPRE1", "MARC1", "MARCKS", "MARS", "MARS2", "MASTL", "MAT2A", "MAT2B", "MAU2", "MAVS", "MBOAT7", "MCAT", "MCCC1", "MCCC2", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCU", "MDC1", "MDH1", "MDH2", "ME2", "MEAF6", "MECP2", "MED1", "MED24", "METAP1", "MFAP1", "MFN1", "MFN2", "MGST2", "MGST3", "MIA2", "MIA3", "MICU1", "MICU2", "MID1", "MIF", "MIGA1", "MINPP1", "MIOS", "MIPEP", "MLEC", "MMAB", "MMS19", "MOGS", "MORF4L1", "MOSPD2", "MOV10", "MPDU1", "MPHOSPH10", "MPI", "MPP1", "MPP2", "MPRIP", "MPST", "MRC2", "MRE11", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL14", "MRPL15", "MRPL17", "MRPL19", "MRPL20", "MRPL21", "MRPL37", "MRPL38", "MRPL39", "MRPL40", "MRPL43", "MRPL44", "MRPL45", "MRPL47", "MRPL48", "MRPL49", "MRPL50", "MRPL53", "MRPL58", "MRPL9", "MRPS15", "MRPS17", "MRPS2", "MRPS22", "MRPS23", "MRPS25", "MRPS27", "MRPS30", "MRPS31", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRPS9", "MSH2", "MSH3", "MSH6", "MSI1", "MSMO1", "MSN", "MTA1", "MTA2", "MTAP", "MTCH1", "MTHFD1", "MTHFD1L", "MTHFD2", "MTOR", "MTR", "MTX1", "MTX2", "MUT", "MYBBP1A", "MYDGF", "MYH10", "MYH14", "MYH9", "MYL6", "MYO6", "NAA35", "NADK2", "NAE1", "NAGK", "NAGLU", "NAMPT", "NANS", "NAPA", "NAPG", "NARS", "NAT10", "NAXE", "NBN", "NCAPD2", "NCAPG", "NCAPH", "NCBP1", "NCBP2", "NCKAP1", "NCL", "NCSTN", "NDC1", "NDUFA10", "NDUFA11", "NDUFA13", "NDUFA2", "NDUFA4", "NDUFA5", "NDUFA7", "NDUFA8", "NDUFA9", "NDUFAF4", "NDUFAF7", "NDUFB10", "NDUFB11", "NDUFB3", "NDUFB4", "NDUFB5", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS7", "NDUFS8", "NDUFV1", "NDUFV2", "NECAP2", "NEFL", "NEK9", "NELFA", "NELFCD", "NELFE", "NFKB1", "NFS1", "NHLRC2", "NHP2", "NIP7", "NIPSNAP2", "NISCH", "NLN", "NME1", "NME2", "NMT1", "NNT", "NOC2L", "NOC4L", "NOL11", "NOL6", "NOL9", "NOP10", "NOP14", "NOP2", "NOP56", "NOP58", "NOSIP", "NPC1", "NPEPPS", "NPLOC4", "NPM1", "NRBP1", "NSD2", "NSDHL", "NSF", "NSFL1C", "NSUN2", "NT5C2", "NT5C3B", "NUB1", "NUBP2", "NUBPL", "NUCB1", "NUDC", "NUDT1", "NUDT21", "NUDT5", "NUDT9", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP160", "NUP188", "NUP205", "NUP210", "NUP214", "NUP35", "NUP37", "NUP50", "NUP54", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NXF1", "OAT", "OCLN", "OGDH", "OGT", "OLA1", "OPA1", "OSBP", "OSBPL11", "OSBPL6", "OSBPL8", "OSBPL9", "OSGEP", "OTUB1", "OXA1L", "P3H1", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPC1", "PABPN1", "PACSIN2", "PACSIN3", "PAF1", "PAFAH1B1", "PAFAH1B3", "PAICS", "PAK1", "PAK2", "PANK4", "PAPSS1", "PARK7", "PARN", "PARP1", "PARP2", "PBRM1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCK2", "PCLAF", "PCM1", "PCMT1", "PCNA", "PDAP1", "PDCD11", "PDCD4", "PDCD6", "PDCD6IP", "PDE12", "PDE6D", "PDHA1", "PDHB", "PDIA3", "PDIA6", "PDK3", "PDLIM5", "PDLIM7", "PDS5A", "PDS5B", "PDXK", "PEBP1", "PECR", "PELP1", "PES1", "PEX14", "PEX19", "PEX5", "PFAS", "PFDN2", "PFDN4", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGP", "PGRMC1", "PGRMC2", "PHB", "PHB2", "PHF5A", "PHF8", "PHGDH", "PI4K2A", "PI4KB", "PICALM", "PIGK", "PIGS", "PIK3C3", "PIN1", "PIP4K2C", "PIR", "PISD", "PITPNA", "PITPNB", "PITRM1", "PKM", "PKMYT1", "PKN1", "PKN2", "PLA2G15", "PLCG1", "PLD3", "PLD6", "PLEC", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLRG1", "PMPCA", "PMPCB", "PNO1", "PNP", "PNPLA8", "POFUT1", "POLA1", "POLA2", "POLD1", "POLDIP2", "POLDIP3", "POLE", "POLE3", "POLE4", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2A", "POLR2B", "POLR2C", "POLR2E", "POLR2G", "POLR2L", "POLR3A", "POLRMT", "PON2", "POP1", "POR", "PPA1", "PPA2", "PPAT", "PPFIA1", "PPIB", "PPID", "PPIE", "PPIH", "PPIL1", "PPIL4", "PPME1", "PPOX", "PPP1CA", "PPP1CB", "PPP1R12A", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP5C", "PPP6C", "PPT1", "PPT2", "PQBP1", "PRC1", "PRCC", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PRIM1", "PRIM2", "PRKACA", "PRKAG1", "PRKAR1A", "PRKAR2A", "PRKCSH", "PRKDC", "PRKRA", "PRMT1", "PRMT3", "PRMT5", "PRPF19", "PRPF3", "PRPF31", "PRPF4", "PRPF40A", "PRPF6", "PRPF8", "PRPS2", "PSAP", "PSAT1", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD6", "PSMD7", "PSMD8", "PSME1", "PSME2", "PSME3", "PSME4", "PSMF1", "PTBP1", "PTCD3", "PTDSS1", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTPN1", "PTRH2", "PUF60", "PUM1", "PUS7", "PWP2", "PXMP2", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QDPR", "QKI", "RAB10", "RAB11B", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB1B", "RAB24", "RAB34", "RAB3GAP1", "RAB3GAP2", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RAB8A", "RAB8B", "RAB9A", "RABEP1", "RABEPK", "RABGAP1", "RAC1", "RACK1", "RAD21", "RAD23A", "RAD23B", "RAD50", "RAD9A", "RAE1", "RALA", "RALB", "RAN", "RANBP1", "RANBP2", "RANBP9", "RANGAP1", "RAP1GDS1", "RAPGEF2", "RARS", "RARS2", "RBBP5", "RBBP6", "RBM14", "RBM17", "RBM22", "RBM28", "RBM4", "RBM5", "RBM8A", "RBMX", "RCC1", "RCC2", "RCL1", "RCN1", "RDH11", "RDH13", "RDH14", "RDX", "REPS1", "RETSAT", "REXO2", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RHEB", "RHOA", "RHOG", "RHOT1", "RIDA", "RIF1", "RINT1", "RIOX2", "RIPK1", "RNASET2", "RNF14", "RNF20", "RNF40", "RNPS1", "ROCK2", "RP2", "RPA1", "RPA2", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPN1", "RPN2", "RPP30", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RRBP1", "RRM1", "RRM2", "RRP1", "RRP8", "RSF1", "RSU1", "RTCB", "RTN3", "RTN4", "RTRAF", "RUFY1", "RUVBL1", "RUVBL2", "S100A10", "S100A11", "SACM1L", "SAE1", "SAFB", "SAMHD1", "SAMM50", "SAP130", "SAP18", "SARNP", "SARS", "SARS2", "SART1", "SC5D", "SCAMP1", "SCARB1", "SCARB2", "SCCPDH", "SCD", "SCFD1", "SCO1", "SCO2", "SCP2", "SCRIB", "SDHA", "SDHB", "SEC11A", "SEC16A", "SEC22B", "SEC23A", "SEC23IP", "SEC24A", "SEC24B", "SEC24C", "SEC31A", "SEC61A1", "SEC61B", "SEH1L", "SEL1L", "SENP3", "SEPT2", "SEPT7", "SERPINB6", "SERPINH1", "SET", "SETD2", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SGPL1", "SGTA", "SH3GL1", "SHMT1", "SHMT2", "SHOC2", "SHTN1", "SIGMAR1", "SIRT1", "SKIV2L", "SKIV2L2", "SKP1", "SKP2", "SLC16A1", "SLC19A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A17", "SLC25A20", "SLC25A22", "SLC25A26", "SLC25A32", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A4", "SLC29A1", "SLC2A1", "SLC33A1", "SLC35B2", "SLC3A2", "SLC7A1", "SLIT2", "SLK", "SLTM", "SMARCA4", "SMARCA5", "SMARCC1", "SMARCC2", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC6", "SMN1*", "SMNDC1", "SMPD4", "SMYD3", "SNAP23", "SNAP29", "SND1", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPC", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNU13", "SNW1", "SNX2", "SNX3", "SNX5", "SNX9", "SOAT1", "SOD2", "SORD", "SORT1", "SPAG9", "SPC24", "SPC25", "SPCS2", "SPEN", "SPPL2A", "SPR", "SPTAN1", "SPTBN1", "SPTBN2", "SPTLC1", "SPTLC2", "SQLE", "SQSTM1", "SRI", "SRM", "SRP14", "SRP54", "SRP68", "SRP72", "SRP9", "SRPK1", "SRPRA", "SRPRB", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF3", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSNA1", "SSR1", "SSR4", "SSRP1", "STAG1", "STAG2", "STAM", "STAMBP", "STARD3", "STARD3NL", "STARD7", "STAT1", "STAT3", "STIP1", "STK4", "STMN1", "STOM", "STOML2", "STRAP", "STRN", "STT3A", "STUB1", "STX18", "STX5", "STXBP3", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGT1", "SUN1", "SUPT16H", "SUPT5H", "SUPT6H", "SURF4", "SUZ12", "SV2A", "SYMPK", "SYNE2", "TACC3", "TAF15", "TAGLN2", "TALDO1", "TARS", "TARS2", "TBC1D10B", "TBC1D13", "TBC1D15", "TBC1D4", "TBCA", "TBCC", "TBCD", "TBCE", "TBL3", "TCEA1", "TCP1", "TDP2", "TDRKH", "TECR", "TERF2IP", "TEX10", "TEX264", "TFAM", "TFG", "TFRC", "THOC1", "THOC2", "THOC3", "THOC6", "THOP1", "THRAP3", "THUMPD1", "TIA1", "TIAL1", "TIGAR", "TIMM10", "TIMM17A", "TIMM17B", "TIMM23", "TIMM44", "TIMM50", "TIMM8B", "TJP1", "TK1", "TKFC", "TKT", "TLN1", "TMED10", "TMED2", "TMED5", "TMED7", "TMED9", "TMOD1", "TMOD3", "TMPO", "TMPO", "TMX3", "TNKS1BP1", "TNPO1", "TOLLIP", "TOMM20", "TOMM22", "TOMM40", "TOMM5", "TOMM70", "TOP1", "TOP2A", "TOP2B", "TOR1AIP1", "TP53", "TP53BP1", "TPD52", "TPI1", "TPM1", "TPM3", "TPM4", "TPP1", "TPP2", "TPR", "TPX2", "TRA2B", "TRAM1", "TRAP1", "TRAPPC5", "TRIM21", "TRIM24", "TRIM25", "TRIM26", "TRIM27", "TRIM28", "TRIM33", "TRIM35", "TRIP12", "TRMT10C", "TSFM", "TSG101", "TSN", "TSNAX", "TSR1", "TTC26", "TTC37", "TTLL12", "TTYH3", "TUBB", "TUBB2A", "TUBB2B", "TUBB4A", "TUBB4B", "TUBB6", "TUBGCP2", "TUBGCP3", "TUFM", "TWF1", "TWF2", "TXLNA", "TXNDC5", "TXNL1", "TXNRD1", "TYMS", "U2AF1", "U2AF2", "U2SURP", "UAP1", "UBA1", "UBA2", "UBA3", "UBA6", "UBE2G2", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2O", "UBE2S", "UBE3A", "UBR4", "UBTF", "UBXN1", "UCHL5", "UFD1", "UFL1", "UGDH", "UGGT1", "UGP2", "UHRF1", "UMPS", "UNC119B", "UNG", "UPF1", "UQCR10", "UQCRB", "UQCRC1", "UQCRC2", "UQCRQ", "UROD", "USO1", "USP10", "USP11", "USP14", "USP15", "USP39", "USP47", "USP48", "USP5", "USP7", "USP9X", "UTP11", "UTP14A", "UTP15", "UTP18", "UTP20", "UTP3", "UTP4", "UTP6", "UTRN", "VAMP7", "VANGL1", "VAPA", "VAPB", "VARS1", "VARS2", "VAT1", "VBP1", "VCL", "VCP", "VDAC1", "VDAC2", "VDAC3", "VIM", "VKORC1L1", "VPS26A", "VPS29", "VPS33B", "VPS35", "VPS4B", "VPS52", "VRK1", "VTA1", "VTI1B", "WAPL", "WARS", "WBP11", "WDR1", "WDR18", "WDR3", "WDR36", "WDR43", "WDR46", "WDR5", "WDR6", "WDR61", "WDR75", "WDR77", "WDR91", "WFS1", "WIPI2", "WNK1", "WTAP", "XAB2", "XPO1", "XPO5", "XPOT", "XRCC1", "XRCC5", "XRCC6", "XRN2", "YARS", "YARS2", "YBX1", "YEATS4", "YKT6", "YME1L1", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZC3H11A", "ZC3HAV1", "ZC3HC1", "ZFYVE16", "ZMYM2", "ZNF638", "ZW10"], "leading_proteins": ["AAAS", "ABCB1", "ABCB7", "ABCD3", "ABHD10", "ACAD9", "ACAT2", "ACOT8", "ACOX1", "ACOX3", "ACP6", "ACSL4", "ADH5", "ADK", "AGPS", "AHCYL1", "AKT2", "ALDH1B1", "ALDH3A2", "ALG1", "ANAPC5", "ANKLE2", "APC", "APOOL", "APP", "APPL1", "ARHGAP17", "ASNA1", "ATAD1", "ATP13A1", "ATP2A2", "ATP5L", "ATP6V0A1", "ATP6V0A2", "B3GALT6", "BAG4", "BAG6", "BAIAP2", "BCAP31", "BLVRB", "CALU", "CAMK2G", "CANX", "CARM1", "CASK", "CASP6", "CASP7", "CCNB1", "CCT7", "CDK1", "CDK4", "CERS1", "CERS2", "CHID1", "CHKA", "CHST14", "CKAP4", "CLCN3", "COASY", "COMT", "COPS2", "COPS4", "COPS6", "COX15", "COX4I1", "CPOX", "CPT2", "CSNK1A1", "CSNK2B", "CTBP1", "CTSC", "CYB5B", "CYP51A1", "DAGLB", "DCTN3", "DERL1", "DHCR24", "DHCR7", "DUSP9", "DYNC1I2", "EBP", "ECE1", "ECH1", "EIF2B2", "EIF2B3", "EMD", "EPHX1", "ERCC3", "EXOSC3", "EXOSC8", "FASN", "FDFT1", "FGFR1OP", "FKBP14", "FKBP1A", "FNTB", "GBA", "GDAP1", "GGCX", "GLUD1", "GNAI1", "GNAI2", "GNAI3", "GOLIM4", "GPAM", "GPD2", "GPX8", "GRB2", "GSK3A", "GSK3B", "GTF2E1", "GUSB", "HACD3", "HADH", "HADHA", "HAUS4", "HAUS5", "HEBP1", "HLA-B", "HM13", "HMGB1", "HMOX1", "HMOX2", "HNRNPA1", "HNRNPC", "HNRNPF", "HNRNPH1", "HNRNPK", "HS2ST1", "HSD17B12", "ICMT", "IGF2BP1", "IPO9", "ITCH", "ITGB1", "KDSR", "KHDRBS1", "KHDRBS3", "KHSRP", "KYAT3", "LBR", "LETM1", "LMNA", "LNPEP", "LSS", "LTA4H", "MAIP1", "MAP2K1", "MAP2K2", "MAPK1", "MAPK14", "MAVS", "MBOAT7", "MCM3", "MCM6", "METAP1", "MFN1", "MIA2", "MICU2", "MIPEP", "MMAB", "MOGS", 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pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Cholesterol metabolism with bloch and kandutschrussell pathways 10 22 3.153379484912489 0.0016139185231873 7.092233009708738 23.070388349514563 1.3045876527781233 0.2885598195159411 3.1892169450204397 2.132138915277104 1.1515799969949023 0.3088028425519339 2.590882432831862e-07 0.0007225305704933 0.0004319372914338 6.620879548016799e-10 7.739779835107354e-10 +Alzheimers disease and mirna effects 22 83 3.0897397745571715 0.0020033193218882 19.78640776699029 84.62864077669903 0.8675405351918691 0.5019659822826982 9.06411947478317 6.212690980603589 1.0744065053186531 0.3869842050583563 0.0034964135427161 0.0150464465152649 0.0031795225235907 0.0032939370021869 0.0001016374514712 +Alzheimers disease 20 81 2.931829215969304 0.003369719989279 18.929611650485437 83.0752427184466 0.8523996335219438 0.5089902911900335 9.09856474570077 6.061710858604258 1.0800674607776464 0.3865214102951685 0.0031362294341892 0.0143014435113341 0.0029219793201296 0.0029098013174956 0.0005676224773612 +Mecp2 and associated rett syndrome 6 16 2.3633885118529308 0.0181086743541112 5.592233009708738 20.259708737864077 0.3268423909291167 0.6185500925876379 2.618777945204404 2.325048890314102 0.8108267988896323 0.3183114931796179 0.0657963288940516 1.0 1.0 0.0345596402774107 0.0112872973833843 +Angiopoietinlike protein 8 regulatory pathway 4 25 2.2662539004719973 0.0234358421903755 7.575242718446602 28.25242718446602 0.0554077707393526 0.6876386171429575 4.071171283635633 4.140654342084138 0.7247314269394591 0.2975639551036786 0.3100919480322761 0.4043878907472013 0.2786826950506385 0.482172538788556 0.4229003918890686 +Oxidation by cytochrome p450 3 5 2.1948291227780783 0.0281758575827553 2.3179611650485437 5.422330097087379 1.262256455948566 0.1900711291682963 1.161003800051733 0.6764315332620536 1.214909583878196 0.2447393771863318 6.74023216647181e-05 0.0017062060788896 0.0002366501305723 0.0002022933287296 0.0028040242445346 +Sterol regulatory elementbinding proteins srebp signaling 6 29 2.1253369349351248 0.0335585084449161 6.300970873786408 30.54368932038835 0.0430177686305986 0.5142337447508607 3.4713388241658825 3.5690870689043055 0.9393928812893728 0.2926573122252184 0.0011500757053517 0.003696507335194 0.0035993555519234 0.0009457816918193 0.0040466728259346 +Sphingolipid metabolism integrated pathway 4 7 2.1216923427069028 0.0338635820713493 4.058252427184466 8.101941747572816 1.3056837288293504 0.1731905617886817 2.1182299017960826 1.603786816240382 1.4154175704443392 0.233855234687812 0.0046672984761978 0.0036723611473879 0.0143328298354406 0.0102137155300364 0.0017743753624758 +Sphingolipid metabolism overview 4 7 2.1216923427069028 0.0338635820713493 4.0 7.951456310679611 1.305604070038762 0.1692072490812911 2.0060587839493125 1.5113078035984122 1.4254327231792938 0.2283290755268721 0.0033641802428605 0.0029386578360865 0.0115435449528709 0.0074273483269255 0.0010238181908857 +Overlap between signal transduction pathways contributing to lmna laminopathies 8 14 2.1123861054918107 0.0346533457788404 4.927184466019417 14.766990291262136 1.2077866030529698 0.2877996039599693 1.943257907759383 1.4611731122572065 0.935661776029738 0.2919054664837305 0.19797272805708 0.1952735388158895 0.3559802976275766 0.2978006616879862 0.0056815658241212 +Sphingolipid pathway 4 8 2.096965750952396 0.0359966072704991 4.274271844660194 9.393203883495143 1.2258474538683668 0.1888473674707098 2.02173101931241 1.3620203536909472 1.3696572221543342 0.2416569853225122 0.0602292764146611 0.0049155620827658 0.0190005699483642 0.0153906222854723 0.0035606647558243 +Nonalcoholic fatty liver disease 13 52 2.076498150972014 0.0378479019610817 14.446601941747574 49.78883495145631 0.8140299356769594 0.4039994838731682 5.918094936421778 5.382150615191258 1.5259550974793896 0.3817978315095583 0.0805075996919474 0.1225807784723296 0.0075508250565443 0.0855245570517092 0.0003972578996573 +Sphingolipid metabolism in senescence 4 10 2.037492104245489 0.0416007523857613 4.349514563106796 11.679611650485436 1.1898351622318797 0.2087194733713789 1.8732078185138223 1.4259290429724831 1.4063103725171229 0.2533781048666968 0.0651952457446114 0.0053672672920639 0.0206800818926893 0.0173886328284286 0.0236194052560011 +Statin inhibition of cholesterol production 2 5 2.004764204451876 0.0449882609920606 2.0315533980582523 5.029126213592233 1.044092701346018 0.2144191485801186 1.2890406286437517 1.2084356467042294 1.2621579412510306 0.2395890160394713 0.0260812181848141 0.001984476440523 0.0078714328443906 0.0041946485896371 0.0280386150660574 +Autophagy 0 5 1.984298483968815 0.0472225750984727 2.953883495145631 7.742718446601942 -0.0299757245624393 0.565000914214197 1.9964311522439036 2.4793947719737557 0.8878312946310102 0.3070201262234293 0.4141299082706836 0.1305522111527444 0.2467424796819782 0.5094216597603356 0.7657233578788754 +Familial partial lipodystrophy fpld 2 7 1.973221341649924 0.0484703500062853 2.7354368932038833 7.351941747572815 1.0487704575374006 0.2220749325398317 1.64741826657551 0.7567951823729889 1.2080189526980365 0.2461617416466816 0.0062371431889486 0.0963063052639835 0.0173819675279631 0.0135296171343662 0.0798154053066686 diff --git a/msigdb_wp/metrics.json b/msigdb_wp/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..40f2335633be173784ac10348097e2ddedf2ad11 --- /dev/null +++ b/msigdb_wp/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2734, + "annotations_size": 598, + "title": "Average number of proteins per term", + "value": 9.847826086956522 +} \ No newline at end of file diff --git a/msigdb_wp/paths.json b/msigdb_wp/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..5b4bd1d4f7f5f8d0ddf4c5943e2ae3b070ace359 --- /dev/null +++ b/msigdb_wp/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/msigdb_wp/fragment/C166/C166_val_log2fc"} \ No newline at end of file diff --git a/msigdb_wp/result.tsv b/msigdb_wp/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..978048bbf63fc4827de0ce225b1b54ec32ed272d --- /dev/null +++ b/msigdb_wp/result.tsv @@ -0,0 +1,172 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Cholesterol metabolism with bloch and kandutschrussell pathways 0.7127092783854578 3.153379484912489 0.0016139185231873 0.619360646548403 0.0317593940120237 22 Q15125,Q15800,Q16850,Q15392,P37268,Q14739,P48449,Q9BWD1,O00767,Q14534 10 +Alzheimers disease and mirna effects 0.4771771918057317 3.0897397745571715 0.0020033193218882 0.6985606767711714 0.0342281415568334 83 Q8NEB9,Q9Y277,P21796,P25054,P45880,P16615,Q9NQC3,P48729,O43242,Q99436,P36507,P05067,Q96IX5,P49721,Q96GC9,O95197,P28070,P31751,P20618,Q9H0B6,P28072,P48556 22 +Congenital generalized lipodystrophy cgl 0.9008052708638398 2.9826931864091195 0.0028572426344997 0.8193288483494819 0.0449639761955481 2 P31751 1 +Metabolism of spingolipids in er and golgi apparatus 0.8934846266471501 2.9493373774290856 0.0031845612194909 0.8515350462030087 0.0481001357943941 2 Q06136 1 +Alzheimers disease 0.4660379982664483 2.931829215969304 0.003369719989279 0.8671447844860884 0.0491485988680211 81 Q8NEB9,Q9Y277,P21796,P25054,P45880,P16615,Q9NQC3,P48729,O43242,Q99436,P36507,P05067,P49721,O95197,P28070,P31751,P20618,Q9H0B6,P28072,P48556 20 +Nuclear receptors in lipid metabolism and toxicity 0.846632503660329 2.732712418276504 0.0062815151997808 0.9769062555506424 0.0741299125627375 2 P08183 1 +Eicosanoid synthesis 0.9513809413377128 2.724562685655006 0.0064386706490238 0.9789903621393284 0.0741299125627375 3 P09960 1 +Proteoglycan biosynthesis 0.9271329183449286 2.6227744589426623 0.0087216988149683 0.9946915391776968 0.0802396290977085 3 Q8NCH0,Q8TB61 2 +Relationship between inflammation cox2 and egfr 0.9193511572748668 2.589854163223094 0.0096016599092119 0.996878793724448 0.0850530904426042 3 P31751 1 +Vitamin d metabolism 0.8853899670450384 2.444728127548092 0.014496137095352 0.9998386823456435 0.1097302529496267 3 P04062,Q9UBM7 2 +Mecp2 and associated rett syndrome 0.6493230803582305 2.3633885118529308 0.0181086743541112 0.9999820556736508 0.1204235786917135 16 P35637,Q00013,Q99640,P52597,P31943,Q05086 6 +Folatealcohol and cancer pathway hypotheses 0.754026354319187 2.288100380299276 0.0221316761120964 0.9999984594840816 0.1249278335408245 2 Q99707 1 +Angiopoietinlike protein 8 regulatory pathway 0.5616919843253393 2.2662539004719973 0.0234358421903755 0.999999306467514 0.1249278335408245 25 P41440,Q8NEB9,P31751,O00767 4 +Urea cycle and related diseases 0.7426793557833106 2.2321062648846737 0.0256079404774434 0.9999998168637876 0.1297758339450098 2 Q9Y619 1 +Oxidation by cytochrome p450 0.9233168506649598 2.1948291227780783 0.0281758575827553 0.9999999622049528 0.1381078920859645 5 Q6UW02,Q16850,O43169 3 +Sterol regulatory elementbinding proteins srebp signaling 0.5214993289346707 2.1253369349351248 0.0335585084449161 0.9999999986354512 0.1557724775282068 29 Q8WTV0,Q9HCL2,Q16850,P37268,P48449,O00767 6 +Sphingolipid metabolism integrated pathway 0.8370902573419913 2.1216923427069028 0.0338635820713493 0.9999999988702176 0.1557724775282068 7 Q06136,Q96G23,P27544,O95470 4 +Sphingolipid metabolism overview 0.8370902573419913 2.1216923427069028 0.0338635820713493 0.9999999988702176 0.1557724775282068 7 Q06136,Q96G23,P27544,O95470 4 +Overlap between signal transduction pathways contributing to lmna laminopathies 0.642335494737089 2.1123861054918107 0.0346533457788404 0.9999999993071952 0.1581885555400505 14 P55209,O75844,O60725,P42167,P11802,P48729,P25054,P50402 8 +Sphingolipid pathway 0.80556695814062 2.096965750952396 0.0359966072704991 0.9999999996987132 0.1595571770849859 8 Q06136,P04062,Q96G23,O95470 4 +Nonalcoholic fatty liver disease 0.445400442033757 2.076498150972014 0.0378479019610817 0.9999999999045556 0.1640075751646877 52 Q86Y39,P13073,O95168,Q96GC9,P14406,P21912,O14949,O75306,O96000,Q9Y6M9,P31751,O43676,Q9UDW1 13 +Sphingolipid metabolism in senescence 0.7407298563346657 2.0374921042454894 0.0416007523857613 0.9999999999907788 0.1776946423334662 10 Q06136,O15269,P04062,Q96G23 4 +Tlr4 signaling and tolerance 0.791825448405207 2.032680064995717 0.0420848566116152 0.9999999999931832 0.178487547898907 3 Q15629 1 +Statin inhibition of cholesterol production 0.8762240791915277 2.004764204451876 0.0449882609920606 0.9999999999988904 0.1842669868030977 5 Q8WTV0,P37268 2 +Familial partial lipodystrophy fpld 0.8035273677204922 1.973221341649924 0.0484703500062853 0.9999999999998752 0.1916804126406404 7 O60725,P31751 2 +Cholesterol biosynthesis pathway 0.6992070389784081 1.95914555595479 0.0500957429905917 0.999999999999955 0.1931582378263657 11 Q15800,Q16850,P37268,P48449,Q14534 5 +Kallmann syndrome 0.7702903175159399 1.935377124936157 0.0529440342882185 0.9999999999999926 0.2003831171161691 3 P62993 1 +Photodynamic therapyinduced nfe2l2 nrf2 survival signaling 0.8567801205755925 1.9325053216113233 0.0532971658589236 0.999999999999994 0.2004509759977128 4 P07099 1 +Exrna mechanism of action and biogenesis 0.6797218155197662 1.9156107412546544 0.0554146613290467 0.9999999999999984 0.2058258849364592 2 Q9HAV4 1 +Allograft rejection 0.6525919086768486 1.8813639754154263 0.0599224238179467 1.0 0.2193922853063847 12 Q9BY49,P08183,P08670 3 +Influence of laminopathies on wnt signaling 0.6828653352537021 1.873623562661309 0.0609823280298684 1.0 0.2209781954896135 11 O75844,O60725,P48729,P25054,P50402 5 +Kennedy pathway from sphingolipids 0.8413728996426182 1.8692387265212664 0.0615896086089611 1.0 0.2209781954896135 4 P35790,O95470 2 +Somatroph axis gh and its relationship to dietary restriction and aging 0.6621522693997084 1.8256207747981412 0.0679074042825287 1.0 0.23305306327104 2 Q96EB6 1 +Type ii diabetes mellitus 0.6621522693997085 1.8256207747981412 0.0679074042825287 1.0 0.23305306327104 2 P28482 1 +Cholesterol biosynthesis with skeletal dysplasias 0.7702086563719608 1.8236754842932552 0.0682011472783143 1.0 0.23305306327104 7 Q15125,Q16850,Q15392,Q14739 4 +Electron transport chain oxphos system in mitochondria 0.4240991214956039 1.8087799959405717 0.0704851892496647 1.0 0.2381364020977373 47 P13073,O95168,O75964,P14406,P21912,O14949,O75306,O96000,O43676,Q9UDW1 10 +Ovarian infertility 0.6577598828696987 1.8030186827068235 0.0713852806216008 1.0 0.2384826693392029 2 P11802 1 +Metapathway biotransformation phase i and ii 0.5200310716217105 1.7861577454845388 0.0740737205164432 1.0 0.2407395916784405 21 Q16850,P21964,Q8NCH0,Q6UW02,P07099 5 +Insulin signaling 0.4576249888712771 1.7769251626033364 0.0755805537267297 1.0 0.2443090331274832 33 P11166,Q8NEB9,P62993,P41440,P46976,P31751 6 +Cardiac progenitor differentiation 0.6508052708638371 1.7671499740700776 0.0772031150901866 1.0 0.2482121657200623 2 P49841 1 +Sars coronavirus and innate immunity 0.6394582723279676 1.708419766690649 0.0875584820969432 1.0 0.271295193233016 2 Q7Z434 1 +Amyotrophic lateral sclerosis als 0.6647487040561738 1.6534501406167794 0.0982392854728539 1.0 0.2997300648610545 10 Q9BUN8,O96008,P07197,P07196 4 +Omega3 omega6 fatty acid synthesis 0.7521731861060809 1.641724359937472 0.1006471409086045 1.0 0.3002673055198104 6 O15254,O60488,Q15067 3 +Ferroptosis 0.4939946880096839 1.6391813843580714 0.1011754895927852 1.0 0.3002673055198104 22 P37268,P16435,P45880,P09601,Q9NZ45 5 +Mitochondrial complex i assembly model oxphos system 0.4888971144560829 1.6384190787859247 0.1013343019047843 1.0 0.3002673055198104 23 Q9H845,Q96CU9,O95168,Q9NX14,O75306,Q9P0J0,Q7L592,O96000,Q9Y6M9,O43676 10 +Eicosanoid metabolism via lipooxygenases lox 0.7842559588434327 1.623641406452243 0.1044523629333322 1.0 0.3064991688247614 5 P09960,O15254 2 +Dna damage response only atm dependent 0.5050192612462067 1.5639870181253568 0.1178206171487548 1.0 0.3354322456774227 18 Q8NEB9,P31751,P25054 3 +Mitochondrial complex iii assembly 0.6535612934910666 1.483366149320103 0.1379771560165008 1.0 0.3716681950354392 9 P22695,O14949,Q9NVA1,P31930,Q9UDW1 5 +Ciliopathies 0.5499625022433768 1.4618507608526543 0.1437821105149499 1.0 0.3855681707979375 13 O43924,Q13432 2 +Adipogenesis 0.5198547816435127 1.4473199710600808 0.1478073282394436 1.0 0.3931894129586689 15 O75844,Q9NZ45 2 +Synaptic signaling pathways associated with autism spectrum disorder 0.6634918871740682 1.4283703613016197 0.1531852854123621 1.0 0.4029580945749746 8 P31751 1 +Methionine metabolism leading to sulfur amino acids and related disorders 0.7284541447817207 1.3961366218964364 0.1626733575508949 1.0 0.4177575158791984 4 P55263 1 +7oxoc and 7betahc pathways 0.6284445705111898 1.3573553782576089 0.1746683191776625 1.0 0.4255429854624147 9 Q15125,O15118,Q9UBM7 3 +Mitochondrial long chain fatty acid betaoxidation 0.5281650669072971 1.3303222027859944 0.1834121348548181 1.0 0.4404837616192017 13 O43772,P23786,Q9BY49,P40939,Q16836 5 +Phosphoinositides metabolism 0.7068466447306442 1.304286062398018 0.1921360656295592 1.0 0.4485478180421375 4 Q8TBX8,Q8NEB9 2 +Wnt signaling 0.5235624060540882 1.3024267282079356 0.1927705505632597 1.0 0.4485478180421375 13 Q13363,Q8TAA9,Q13555,P25054 4 +Omega9 fatty acid synthesis 0.6750693018509317 1.2970109901535396 0.1946274053890038 1.0 0.4511131334210243 6 O60488,O00767 2 +Ppar signaling pathway 0.4937817169219186 1.2780731903351243 0.2012236208811799 1.0 0.4619101221201585 15 O15254,O00767,P23786 3 +Estrogen receptor pathway 0.6221960987989917 1.247083286423789 0.2123669606100726 1.0 0.4721020165235072 3 Q9HCL2 1 +Endothelin pathways 0.6255352131902203 1.244559375218646 0.213293761212487 1.0 0.4724061822409897 8 P42892 1 +Kisspeptinkisspeptin receptor system in the ovary 0.6934247434604501 1.2377189758434106 0.2158202805322873 1.0 0.4727491859278674 5 P31751 1 +Ccl18 signaling pathway 0.5845704950427772 1.2355840690929571 0.216613209387785 1.0 0.4727543766930491 10 Q86UE4,P11166,P08670,Q96GC9 4 +Glycerophospholipid biosynthetic pathway 0.6565925957917997 1.2137548594216656 0.2248413485784466 1.0 0.4853975684112313 6 Q9HCL2 1 +Ketogenesis and ketolysis 0.6461302970549332 1.1665922751053952 0.2433750644481542 1.0 0.5175861735177106 6 O43772,P23786 2 +Vitamin d receptor pathway 0.5706293926395369 1.1621720268426643 0.2451655948732043 1.0 0.5175861735177106 10 P08183 1 +Copper homeostasis 0.6264153733302957 1.1592656475325696 0.2463479197601144 1.0 0.5175861735177106 7 P05067,O43819,P25054 3 +Erbb signaling pathway 0.484025572607261 1.1410030176024626 0.2538686672505044 1.0 0.5308163042510546 14 P62993,P31751,Q13555,P36507 4 +Oxidative phosphorylation 0.4107258205386127 1.134318574260891 0.2566609406127602 1.0 0.5347848170258906 27 Q86Y39,O75964,O95168,O75306,O96000 5 +Cellular proteostasis 0.6606815683400481 1.0978580940263971 0.2722664591997024 1.0 0.5614322158669725 5 O15212,P61758,Q9UHV9,Q9NQP4 4 +Glycerolipids and glycerophospholipids 0.659666353824832 1.0935280550422593 0.2741620180302941 1.0 0.5615691427354275 5 Q9HCL2 1 +Spinal cord injury 0.4352164298600204 1.0934163923108144 0.2742110195296736 1.0 0.5615691427354275 19 P62942,Q9NQC3 2 +Head and neck squamous cell carcinoma 0.4879056910306258 1.0853946571162898 0.277746897757896 1.0 0.5668690950826685 13 P62942 1 +15q112 copy number variation syndrome 0.6536252634433343 1.0778906201324805 0.2810825718566176 1.0 0.5700715445707082 4 Q96CW5,Q9BSJ2 2 +Tryptophan metabolism 0.4734175564867633 1.0738241533326158 0.2829015023945389 1.0 0.5715374947024807 14 Q16836,Q15392,P51648 3 +Circadian rhythm genes 0.3647870510743841 1.0334813203519042 0.3013787077376277 1.0 0.5937503249442564 38 P23246,P04818,P11802,Q9NRV9,Q14103,P54802,Q15233,Q05086,P00813,Q9BQ04,Q9BWF3 11 +Ncrnas involved in wnt signaling in hepatocellular carcinoma 0.5460859716095705 1.032897125906704 0.301652043939022 1.0 0.5937503249442564 10 Q86UE4,Q13363,P25054 3 +Bile acids synthesis and enterohepatic circulation 0.5756133284511169 1.0281586159878409 0.3038752216686227 1.0 0.5957946969109389 3 P28482,P51114 2 +Vitamin b12 disorders 0.571658978380205 1.0096815379244737 0.3126478904598786 1.0 0.6070241509578163 3 Q96EY8 1 +Steroid biosynthesis 0.5032942898975168 0.9935625719185768 0.3204358734504158 1.0 0.617130790781085 2 P51659 1 +Progeriaassociated lipodystrophy 0.5551013685281626 0.9870514371114728 0.323617423103026 1.0 0.617130790781085 9 O60725 1 +Regulation of wnt bcatenin signaling by small molecule compounds 0.6229380217746016 0.9482343937626052 0.3430101414758075 1.0 0.636078575822415 4 P25054 1 +Oxysterols derived from cholesterol 0.5642269989446287 0.94713984171182 0.3435675250679599 1.0 0.636078575822415 8 Q15125,Q9UBM7 2 +Mapk cascade 0.5953428561570542 0.9384994013641698 0.3479878244623346 1.0 0.6402975970106959 6 P62993 1 +Constitutive androstane receptor pathway 0.6186744989891233 0.9195662536900402 0.3577994683904077 1.0 0.6503467540956348 5 P08183 1 +Endometrial cancer 0.4811641446239941 0.9043407040817044 0.3658147695471094 1.0 0.6571094201002169 12 P62993,P31751,P25054 3 +Tnfrelated weak inducer of apoptosis tweak signaling pathway 0.5040509403698078 0.9036094627624902 0.3662025218320559 1.0 0.6571094201002169 11 P31751 1 +Lncrna in canonical wnt signaling and colorectal cancer 0.457304016031366 0.8989983806711108 0.3686535231883387 1.0 0.6571094201002169 13 Q13363,P61978,P25054 3 +Disruption of postsynaptic signaling by cnv 0.5625671830205646 0.8622845821311589 0.3885309348859194 1.0 0.6813533696826387 7 Q14168 1 +Vitamin b12 metabolism 0.5428856890747793 0.8446152140702532 0.39832571176314 1.0 0.6827162324736072 8 Q8WTV0,Q96EY8 2 +Eicosanoid metabolism via cyclooxygenases cox 0.5945068300888547 0.8183584320717695 0.4131525499648671 1.0 0.6920594534425506 5 O15254 1 +Praderwilli and angelman syndrome 0.5577828613514271 0.7725601674475365 0.4397827257786306 1.0 0.7222360287903596 6 Q15154,Q05086 2 +Cardiac hypertrophic response 0.492150086236241 0.7515943934060069 0.4522950159980925 1.0 0.7349794009969003 10 P31751 1 +Genes related to primary cilium development based on crispr 0.5037993444121903 0.7314336452136875 0.4645143207572 1.0 0.7487319779320906 9 A0AVF1,O95684 2 +1q211 copy number variation syndrome 0.5330395930634191 0.7277704843033868 0.4667540953012103 1.0 0.7503197553497951 7 Q9NPH0 1 +Thermogenesis 0.3709659563767549 0.7158214929532613 0.4741015793037233 1.0 0.7548330576828223 23 O43772,P23786 2 +Histone modifications 0.5676640644613443 0.7079413192100529 0.478981699038062 1.0 0.7597640743362362 5 Q8IYR2 1 +Male infertility 0.3865668046786837 0.7028655754322518 0.4821395261481418 1.0 0.7607372998326881 17 Q15165,P08183,P41440 3 +Embryonic stem cell pluripotency pathways 0.4437743726357519 0.6912903280895152 0.4893831086910856 1.0 0.7681131207277406 12 P62993,P31751,P25054 3 +Joubert syndrome 0.3762710780144918 0.6467776030559511 0.5177758897172295 1.0 0.7838590155020017 18 P61006,O43924,Q10713,Q13432 4 +Erk pathway in huntingtons disease 0.5487179487179501 0.6439799351337113 0.5195884452834347 1.0 0.7838590155020017 4 P42574,P55210,P28482 3 +Wnt signaling pathway 0.4290756657349944 0.6093370475884072 0.5423010554859711 1.0 0.8089208560980997 12 P48729,Q13363,P25054 3 +Methionine de novo and salvage pathway 0.5013041753467321 0.5873524596654689 0.5569670153890294 1.0 0.8256116791624416 7 Q13126,Q99707 2 +Nephrotic syndrome 0.4412553995689295 0.5677773867954737 0.5701861365147631 1.0 0.8357139942054617 11 Q14108 1 +Bladder cancer 0.5312787527232923 0.5632774251682163 0.5732459878131033 1.0 0.8366588594961346 5 P36507 1 +Tcell antigen receptor tcr pathway during staphylococcus aureus infection 0.4346599948162938 0.5338445909444979 0.5934490600868476 1.0 0.8422283744881409 11 P62993,Q13153,P36507 3 +Mitochondrial complex iv assembly 0.4340084159870967 0.5305121889990139 0.5957568602148555 1.0 0.8422283744881409 11 Q9Y2R0,P13073,P14406 3 +Orexin receptor pathway 0.3851981424656209 0.5245050436219957 0.59992731273889 1.0 0.8429065889625212 14 P11166,O60313,P31350 3 +Tolllike receptor signaling pathway 0.4130348719979855 0.5217063945646393 0.6018747717173856 1.0 0.8429065889625212 12 P31751,Q13546 2 +Physicochemical features and toxicityassociated pathways 0.3590385555536308 0.5147088281687857 0.6067565034571869 1.0 0.8476703436634488 17 P62993,P07197,P25054,P07196 4 +Interactome of polycomb repressive complex 2 prc2 0.5146520146520162 0.5127712634203927 0.6081113334976915 1.0 0.8476703436634488 4 Q9NYF8,Q15022,Q9UPQ4 3 +Nrp1triggered signaling pathways in pancreatic cancer 0.4428652373356809 0.5050912122694453 0.6134947732620133 1.0 0.8512416998032101 10 P31751,P36507 2 +Mevalonate arm of cholesterol biosynthesis pathway 0.4629829850682675 0.47719692757473 0.633221898752999 1.0 0.8745189271461741 8 P37268 1 +Fatty acid betaoxidation 0.3489049904483877 0.4716788017825467 0.6371560701719168 1.0 0.8748474225748649 19 P43304,O43772,P23786,P40939,Q16836 5 +Mevalonate pathway 0.4469042243236636 0.4595246886165661 0.6458574270692077 1.0 0.8768485561413168 3 Q9BWD1 1 +22q112 copy number variation syndrome 0.3237326191395056 0.4487143968108408 0.6536376977391001 1.0 0.8768485561413168 29 P00367,Q9NQC3 2 +Proximal tubule transport 0.4427815798009467 0.4436696706325087 0.6572814263793751 1.0 0.8793160916663677 9 P11166,P08195,P08183 3 +Purinergic signaling 0.4408641523251556 0.4357999537663605 0.6629818774033869 1.0 0.8829914536463815 3 P08754,P04899 2 +Mthfr deficiency 0.4599502046176154 0.4146376004914051 0.6784072183208414 1.0 0.8937330107707873 7 P21964,Q7L592 2 +Type i interferon induction and signaling during sarscov2 infection 0.4324423288172832 0.4034245649242852 0.6866359184821769 1.0 0.8937330107707873 3 P42224,Q7Z434 2 +Breast cancer pathway 0.3335693751660991 0.3966627757002833 0.6916161536442533 1.0 0.8937330107707873 21 P48729,P25054,P62993,P36507,P31751 5 +Glioblastoma signaling pathways 0.3713300486485585 0.3963361352082205 0.6918570731527272 1.0 0.8937330107707873 13 P62993,P31751,P36507 3 +Mirna biogenesis 0.4280483339436106 0.386877232772733 0.6988470968635878 1.0 0.8937330107707873 3 Q9HAV4,Q9UPY3 2 +Mirnas involvement in the immune response in sepsis 0.3766471449487614 0.3841636669662798 0.7008571455487305 1.0 0.8937330107707873 2 Q16539 1 +Mapk and nfkb signaling pathways inhibited by yersinia yopj 0.3766471449487568 0.3841636669662606 0.7008571455487447 1.0 0.8937330107707873 2 P28482 1 +Neovascularisation processes 0.3766471449487568 0.3841636669662606 0.7008571455487447 1.0 0.8937330107707873 2 P28482 1 +Ltf danger signal response pathway 0.3766471449487568 0.3841636669662606 0.7008571455487447 1.0 0.8937330107707873 2 P28482 1 +Supression of hmgb1 mediated inflammation by thbd 0.3766471449487523 0.3841636669662426 0.700857145548758 1.0 0.8937330107707873 2 P09429 1 +Envelope proteins and their potential roles in edmd physiopathology 0.3350072466535136 0.3575896407966279 0.7206504318302851 1.0 0.908965865291616 17 P62993,P42167,P50402,Q14739 4 +Sulfation biotransformation reaction 0.4174295129989015 0.3479274105055756 0.727894699235234 1.0 0.9092565815771012 3 P00390,P11413 2 +Hedgehog signaling pathway wp4249 0.4640922349212124 0.3349520494203408 0.7376612578460826 1.0 0.917092374619454 4 P48729 1 +Onecarbon metabolism and related pathways 0.3936125157297323 0.3327219795752192 0.7393441566630623 1.0 0.9172776051545876 11 O43865,P35790 2 +Folate metabolism 0.344493335136966 0.3271887192401989 0.7435251525071545 1.0 0.9205549507231436 15 Q8WTV0,P41440 2 +Regulation of apoptosis by parathyroid hormonerelated protein 0.4641980207501661 0.3211612211578967 0.7480882177492842 1.0 0.922613925338338 5 Q07820,Q9BXK5 2 +Sarscov2 b117 variant antagonises innate immune activation 0.3601756954611951 0.3188811109902669 0.749816668418783 1.0 0.922613925338338 2 Q7Z434 1 +Nuclear receptors metapathway 0.2846252548890759 0.2965515265231989 0.7668089230415696 1.0 0.9348966006045548 43 P11166,Q9HCL2,Q15067,P23786,P09601,O00767,P08183 7 +Nanoparticlemediated activation of receptor signaling 0.4277674376164717 0.2919972364461868 0.7702887369402647 1.0 0.9348966006045548 7 P62993 1 +Translation factors 0.2878413429110064 0.2809213518960818 0.7787707233903056 1.0 0.9348966006045548 36 O75153 1 +Striated muscle contraction pathway 0.4224311452085124 0.2729210575983588 0.7849138991699838 1.0 0.9387570234073006 7 P08670 1 +Mirna regulation of prostate cancer signaling pathways 0.3971648489622948 0.2523761452597177 0.800750336817293 1.0 0.944474756246038 9 P62993 1 +Nucleotidebinding oligomerization domain nod pathway 0.4159555940787977 0.2503110742653994 0.8023467929912116 1.0 0.9444948468676072 7 Q7L5N1 1 +Melanoma 0.3328702369762098 0.2313455520396025 0.8170463609439482 1.0 0.9573484024061708 14 P62993,Q13153,P31751,P36507 4 +P53 transcriptional gene network 0.4184927975764427 0.2300297940570793 0.8180686181096208 1.0 0.9573484024061708 6 P11166 1 +Glycosaminoglycan degradation 0.4158079296303917 0.2215931079194474 0.8246306482056065 1.0 0.9603899535009232 6 P08236,P54802 2 +Wnt signaling pathway and pluripotency 0.3308728003429453 0.2211405728784065 0.824982979601792 1.0 0.9603899535009232 14 Q13363,P25054 2 +Osteopontin signaling 0.3767850604174296 0.2144127319706802 0.8302252138554076 1.0 0.9603899535009232 3 Q02750,P28482 2 +Il10 antiinflammatory signaling pathway 0.4294530855565918 0.2143120921915291 0.8303036888962831 1.0 0.9603899535009232 5 P09601,P30043 2 +Proteasome degradation 0.2760987987363846 0.2011353050047395 0.8405927766541481 1.0 0.9629779318758248 41 P20618,P49721,P28072,Q99436,P48556,P28070,P01889 7 +Interactions between loxl4 and oxidative stress pathway 0.3672647381911388 0.1871688174380498 0.8515282728449465 1.0 0.9655097166848456 3 Q16543,Q96EB6 2 +Tcell receptor tcr signaling pathway 0.3189509431354038 0.162198201757875 0.871149775839311 1.0 0.9773875533806904 14 P62993,P08670,P36507 3 +Tnfalpha signaling pathway 0.3010572769823551 0.1583295542966136 0.8741971208926191 1.0 0.9789698095389257 18 P62993,P06737 2 +Energy metabolism 0.3684403669724656 0.1482710858087972 0.882128833295152 1.0 0.986005686561684 9 Q16539,Q99873,Q96EB6,Q15648,Q00059,P49841,P54619,Q13555 8 +Neural crest cell migration in cancer 0.3738745875470203 0.1399598268801005 0.8886917313993401 1.0 0.9870064975815506 8 Q99523,P31751 2 +Hepatitis b infection 0.2923719805342145 0.1366888156209754 0.8912767703913667 1.0 0.9870064975815506 22 P62993,P31751,Q9Y277 3 +Epithelial to mesenchymal transition in colorectal cancer 0.2949394974434288 0.1343663282373438 0.8931129063202807 1.0 0.9870495510447052 20 P62993,Q13153,P31751,P36507 4 +Nongenomic actions of 125 dihydroxyvitamin d3 0.3773377337733951 0.1291699280568674 0.8972231907682144 1.0 0.9870495510447052 7 Q96JM3,Q15648,P28482,P42224,Q16539,Q13555 6 +Regulation of actin cytoskeleton 0.2745720669909988 0.1291621574818682 0.8972293392849908 1.0 0.9870495510447052 33 Q8NEB9,Q8TBX8,Q9UQB8,P25054,P36507 5 +G1 to s cell cycle control 0.290635370229218 0.1260089267759936 0.8997248583575856 1.0 0.9870495510447052 22 Q9Y619,Q14566,P14635,Q99640,P11802,P25205,P15927,Q14181 8 +Malignant pleural mesothelioma 0.2658361063787405 0.1243667623568554 0.901024888795554 1.0 0.9870495510447052 56 P11166,P48729,Q07820,P25054,P62993,Q13363,P31751,P36507,Q4VCS5,P08195,Q13153 11 +Cohesin complex cornelia de lange syndrome 0.300221608024616 0.1196724848328916 0.90474259760609 1.0 0.9890970262677184 16 P25054,Q96FF9 2 +Preimplantation embryo 0.3616950765535561 0.1037835611711421 0.9173411122989744 1.0 0.9992167307008866 8 Q99729 1 +Mrna processing 0.2458114705509032 0.0965947329290367 0.9230482394493462 1.0 1.0 98 P52272,P67809,O43390,P61978,P23246,Q99729,P84103,P35637,Q05048,Q14103,P55795,P09651,P62995,P22626,P38159,Q13242,Q07955,Q9UKF6,P31943,Q15287,Q15233 21 +Estrogen signaling pathway 0.3770611945767626 0.08558115401152 0.9317993804067176 1.0 1.0 5 Q02750,Q16539,P17612,P28482 4 +Nocgmppkg mediated neuroprotection 0.3643573945839885 0.0823006708247784 0.9344076209907926 1.0 1.0 6 Q13555 1 +4hydroxytamoxifen dexamethasone and retinoic acids regulation of p27 expression 0.3582691602493614 0.0790071474992531 0.93702693795515 1.0 1.0 7 P36507,Q02750,P06730,P28482,P42345,Q96KB5 6 +Vitamin dsensitive calcium signaling in depression 0.3704653719311049 0.072444125938038 0.9422484696012848 1.0 1.0 5 P20020,P00390,O60341,P11413 4 +Caloric restriction and aging 0.3597069597069616 0.0685516785819788 0.9453464832333468 1.0 1.0 4 P42345,P43490,Q96EB6 3 +Camkk2 pathway 0.3338236011768483 0.0624697950395933 0.9501887150112588 1.0 1.0 10 P09601 1 +Wntbetacatenin signaling pathway in leukemia 0.3533163409285441 0.0416106678781536 0.966809068871722 1.0 1.0 5 P25054 1 +Interleukin11 signaling pathway 0.3296430343283208 0.0336238556029904 0.9731770990011276 1.0 1.0 9 P62993,Q15257 2 +Mitochondrial immune response to sarscov2 0.3264631418712986 0.025690054718812 0.9795045564252294 1.0 1.0 9 Q9Y6M9 1 +Photodynamic therapyinduced hif1 survival signaling 0.3076426633112461 0.0056007691391039 0.9955312561383508 1.0 1.0 11 P11166,Q07820,P14618 3 diff --git a/msigdb_wp/selections.json b/msigdb_wp/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..27eed3633fa4d1079c90d87d9e285890a08d4713 --- /dev/null +++ b/msigdb_wp/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["15q112 copy number variation syndrome", "15q133 copy number variation syndrome", "16p112 distal deletion syndrome", "16p112 proximal deletion syndrome", "1q211 copy number variation syndrome", "22q112 copy number variation syndrome", "3q29 copy number variation syndrome", "4hydroxytamoxifen dexamethasone and retinoic acids regulation of p27 expression", "7oxoc and 7betahc pathways", "7q1123 copy number variation syndrome", "Acetylcholine synthesis", "Acquired partial lipodystrophy barraquersimons syndrome", "Activation of nlrp3 inflammasome by sarscov2", "Acute viral myocarditis", "Adipogenesis", "Aerobic glycolysis", "Aflatoxin b1 metabolism", "Agerage pathway", "Airway smooth muscle cell contraction", "Alanine and aspartate metabolism", "Allograft rejection", "Alpha 6 beta 4 signaling pathway", "Altered glycosylation of muc1 in tumor microenvironment", "Alternative pathway of fetal androgen synthesis", "Alzheimers disease", "Alzheimers disease and mirna effects", "Amino acid metabolism", "Amino acid metabolism pathway excerpt histidine catabolism extension", "Ampactivated protein kinase ampk signaling", "Amyotrophic lateral sclerosis als", "Androgen receptor signaling pathway", "Angiogenesis", "Angiopoietinlike protein 8 regulatory pathway", "Angiotensin ii receptor type 1 pathway", "Antiviral and antiinflammatory effects of nrf2 on sarscov2 pathway", "Apoptosis", "Apoptosis modulation and signaling", "Apoptosis modulation by hsp70", "Apoptosisrelated network due to altered notch3 in ovarian cancer", "Arachidonate epoxygenase epoxide hydrolase", "Arrhythmogenic right ventricular cardiomyopathy", "Aryl hydrocarbon receptor pathway wp2586", "Aryl hydrocarbon receptor pathway wp2873", "Aspirin and mirnas", "Atm signaling in development and disease", "Atm signaling pathway", "Atr signaling", "Autophagy", "Autosomal recessive osteopetrosis pathways", "B cell receptor signaling pathway", "Base excision repair", "Bdnftrkb signaling", "Benzene metabolism", "Benzoapyrene metabolism", "Bile acids synthesis and enterohepatic circulation", "Biogenic amine synthesis", "Biomarkers for pyrimidine metabolism disorders", "Biomarkers for urea cycle disorders", "Biotin metabolism including iems", "Bladder cancer", "Bmp signaling in eyelid development", "Bmp2wnt4foxo1 pathway in primary endometrial stromal cell differentiation", "Brainderived neurotrophic factor bdnf signaling pathway", "Breast cancer pathway", "Burn wound healing", "Calcium regulation in cardiac cells", "Caloric restriction and aging", "Camkk2 pathway", "Cancer immunotherapy by pd1 blockade", "Cannabinoid receptor signaling", "Canonical and noncanonical notch signaling", "Canonical and noncanonical tgfb signaling", "Canonical nfkb pathway", "Cardiac hypertrophic response", "Cardiac progenitor differentiation", "Ccl18 signaling pathway", "Cell cycle", "Cell differentiation expanded index", "Cell differentiation index", "Cell migration and invasion through p75ntr", "Cells and molecules involved in local acute inflammatory response", "Celltype dependent selectivity of cck2r signaling", "Cellular proteostasis", "Cerebral organic acidurias including diseases", "Chemokine signaling pathway", "Cholesterol biosynthesis pathway", "Cholesterol biosynthesis with skeletal dysplasias", "Cholesterol metabolism with bloch and kandutschrussell pathways", "Chromosomal and microsatellite instability in colorectal cancer", "Ciliary landscape", "Ciliopathies", "Circadian rhythm genes", "Classical pathway of steroidogenesis with glucocorticoid and mineralocorticoid metabolism", "Clear cell renal cell carcinoma pathways", "Codeine and morphine metabolism", "Cohesin complex cornelia de lange syndrome", "Common pathways underlying drug addiction", "Complement and coagulation cascades", "Complement system", "Complement system in neuronal development and plasticity", "Congenital generalized lipodystrophy cgl", "Constitutive androstane receptor pathway", "Control of immune tolerance by vasoactive intestinal peptide", "Copper homeostasis", "Cori cycle", "Corticotropinreleasing hormone signaling pathway", "Cysteine and methionine catabolism", "Cytoplasmic ribosomal proteins", "Cytosine methylation", "Cytosolic dnasensing pathway", "Ddx1 as a regulatory component of the drosha microprocessor", "Degradation pathway of sphingolipids including diseases", "Deregulation of rab and rab effector genes in bladder cancer", "Development of pulmonary dendritic cells and macrophage subsets", "Development of ureteric collection system", "Disorders of folate metabolism and transport", "Disruption of postsynaptic signaling by cnv", "Dna damage response", "Dna damage response only atm dependent", "Dna irdamage and cellular response via atr", "Dna irdouble strand breaks and cellular response via atm", "Dna mismatch repair", "Dna repair pathways full network", "Dna replication", "Dopamine metabolism", "Dopaminergic neurogenesis", "Drug induction of bile acid pathway", "Dual hijack model of vif in hiv infection", "Ebola virus infection in host", "Ebsteinbarr virus lmp1 signaling", "Ectoderm differentiation", "Effect of progerin on genes involved in hutchinsongilford progeria syndrome", "Egfegfr signaling pathway", "Egfr tyrosine kinase inhibitor resistance", "Eicosanoid metabolism via cyclooxygenases cox", "Eicosanoid metabolism via cytochrome p450 monooxygenases pathway", "Eicosanoid metabolism via lipooxygenases lox", "Eicosanoid synthesis", "Electron transport chain oxphos system in mitochondria", "Embryonic stem cell pluripotency pathways", "Endochondral ossification", "Endochondral ossification with skeletal dysplasias", "Endoderm differentiation", "Endometrial cancer", "Endoplasmic reticulum stress response in coronavirus infection", "Endothelin pathways", "Energy metabolism", "Envelope proteins and their potential roles in edmd physiopathology", "Epithelial to mesenchymal transition in colorectal cancer", "Epo receptor signaling", "Erbb signaling pathway", "Erk pathway in huntingtons disease", "Estrogen metabolism", "Estrogen receptor pathway", "Estrogen signaling pathway", "Ethanol effects on histone modifications", "Ethanol metabolism production of ros by cyp2e1", "Eukaryotic transcription initiation", "Exerciseinduced circadian regulation", "Exrna mechanism of action and biogenesis", "Extracellular vesiclemediated signaling in recipient cells", "Extracellular vesicles in the crosstalk of cardiac cells", "Factors and pathways affecting insulinlike growth factor igf1akt signaling", "Familial hyperlipidemia type 1", "Familial hyperlipidemia type 2", "Familial hyperlipidemia type 3", "Familial hyperlipidemia type 4", "Familial hyperlipidemia type 5", "Familial partial lipodystrophy fpld", "Farnesoid x receptor pathway", "Fas ligand pathway and stress induction of heat shock proteins", "Fatty acid betaoxidation", "Fatty acid biosynthesis", "Fatty acid omegaoxidation", "Fatty acid transporters", "Fbxl10 enhancement of maperk signaling in diffuse large bcell lymphoma", "Ferroptosis", "Fgf23 signaling in hypophosphatemic rickets and related disorders", "Fgfr3 signaling in chondrocyte proliferation and terminal differentiation", "Fibrin complement receptor 3 signaling pathway", "Fluoroacetic acid toxicity", "Fluoropyrimidine activity", "Focal adhesion", "Focal adhesion pi3kaktmtorsignaling pathway", "Folate metabolism", "Folatealcohol and cancer pathway hypotheses", "Follicle stimulating hormone fsh signaling pathway", "Foxa2 pathway", "Foxp3 in covid19", "Fragile x syndrome", "Fto obesity variant mechanism", "G protein signaling pathways", "G1 to s cell cycle control", "G13 signaling pathway", "Gaba metabolism aka ghb", "Gaba receptor signaling", "Gammaglutamyl cycle for the biosynthesis and degradation of glutathione including diseases", "Ganglio sphingolipid metabolism", "Gastric cancer network 1", "Gastric cancer network 2", "Gastrin signaling pathway", "Gdnfret signaling axis", "Genes controlling nephrogenesis", "Genes related to primary cilium development based on crispr", "Genes targeted by mirnas in adipocytes", "Glial cell differentiation", "Glioblastoma signaling pathways", "Glucocorticoid receptor pathway", "Glucuronidation", "Glutathione metabolism", "Glycerolipids and glycerophospholipids", "Glycerophospholipid biosynthetic pathway", "Glycogen synthesis and degradation", "Glycolysis and gluconeogenesis", "Glycolysis in senescence", "Glycosaminoglycan degradation", "Glycosylation and related congenital defects", "Gpcrs class a rhodopsinlike", "Gpr143 in melanocytes and retinal pigment epithelium cells", "Gpr40 pathway", "H19 action rbe2f1 signaling and cdkbetacatenin activity", "Hair follicle development cytodifferentiation part 3 of 3", "Hair follicle development organogenesis part 2 of 3", "Head and neck squamous cell carcinoma", "Heart development", "Hedgehog signaling pathway wp4249", "Hedgehog signaling pathway wp47", "Hematopoietic stem cell gene regulation by gabp alphabeta complex", "Heme biosynthesis", "Hepatitis b infection", "Hepatitis c and hepatocellular carcinoma", "Hepatocyte growth factor receptor signaling", "Hereditary leiomyomatosis and renal cell carcinoma pathway", "Hif1a and pparg regulation of glycolysis", "Hijack of ubiquitination by sarscov2", "Hippo signaling regulation pathways", "Hippomerlin signaling dysregulation", "Hippoyap signaling pathway", "Histone modifications", "Homologous recombination", "Hostpathogen interaction of human coronaviruses apoptosis", "Hostpathogen interaction of human coronaviruses autophagy", "Hostpathogen interaction of human coronaviruses interferon induction", "Hostpathogen interaction of human coronaviruses mapk signaling", "Hypertrophy model", "Hypothesized pathways in pathogenesis of cardiovascular disease", "Hypothetical craniofacial development pathway", "Id signaling pathway", "Il1 and megakaryocytes in obesity", "Il1 signaling pathway", "Il10 antiinflammatory signaling pathway", "Il17 signaling pathway", "Il18 signaling pathway", "Il2 signaling pathway", "Il3 signaling pathway", "Il4 signaling pathway", "Il5 signaling pathway", "Il6 signaling pathway", "Il7 signaling pathway", "Il9 signaling pathway", "Imatinib and chronic myeloid leukemia", "Immune response to tuberculosis", "Inclusion body myositis", "Influence of laminopathies on wnt signaling", "Inhibition of exosome biogenesis and secretion by manumycin a in crpc cells", "Initiation of transcription and translation elongation at the hiv1 ltr", "Insulin signaling", "Insulin signaling in adipocytes diabetic condition", "Insulin signaling in adipocytes normal condition", "Integrated cancer pathway", "Integrinmediated cell adhesion", "Interactions between immune cells and micrornas in tumor microenvironment", "Interactions between loxl4 and oxidative stress pathway", "Interactome of polycomb repressive complex 2 prc2", "Interferon type i signaling pathways", "Interleukin1 il1 structural pathway", "Interleukin1 induced activation of nfkb", "Interleukin11 signaling pathway", "Intracellular trafficking proteins involved in cmt neuropathy", "Intraflagellar transport proteins binding to dynein", "Irinotecan pathway", "Iron metabolism in placenta", "Joubert syndrome", "Kallmann syndrome", "Kennedy pathway from sphingolipids", "Ketogenesis and ketolysis", "Ketone bodies synthesis and degradation", "Kininkallikrein pathway", "Kisspeptinkisspeptin receptor system in the ovary", "Kit receptor signaling pathway", "Krebs cycle disorders", "Kynurenine pathway and links to cell senescence", "Leptin and adiponectin", "Leptin signaling pathway", "Leptininsulin signaling overlap", "Leukocyteintrinsic hippo pathway functions", "Linoleic acid metabolism affected by coronavirus infection", "Lipid metabolism pathway", "Lipid particles composition", "Liver x receptor pathway", "Lncrna in canonical wnt signaling and colorectal cancer", "Lncrnamediated mechanisms of therapeutic resistance", "Ltf danger signal response pathway", "Lung fibrosis", "Male infertility", "Malignant pleural mesothelioma", "Mammalian disorder of sexual development", "Mammary gland development pathway embryonic development stage 1 of 4", "Mammary gland development pathway involution stage 4 of 4", "Mammary gland development pathway pregnancy and lactation stage 3 of 4", "Mammary gland development pathway puberty stage 2 of 4", "Map3k1 role in promoting and blocking gonadal determination", "Mapk and nfkb signaling pathways inhibited by yersinia yopj", "Mapk cascade", "Mapk pathway in congenital thyroid cancer", "Mapk signaling pathway", "Matrix metalloproteinases", "Mbdnf and probdnf regulation of gaba neurotransmission", "Measles virus infection", "Mechanoregulation and pathology of yaptaz via hippo and nonhippo mechanisms", "Mecp2 and associated rett syndrome", "Melanoma", "Melatonin metabolism and effects", "Mesodermal commitment pathway", "Met in type 1 papillary renal cell carcinoma", "Metabolic pathway of ldl hdl and tg including diseases", "Metabolic reprogramming in colon cancer", "Metabolism of alphalinolenic acid", "Metabolism of spingolipids in er and golgi apparatus", "Metapathway biotransformation phase i and ii", "Metastatic brain tumor", "Methionine de novo and salvage pathway", "Methionine metabolism leading to sulfur amino acids and related disorders", "Methylation pathways", "Mevalonate arm of cholesterol biosynthesis pathway", "Mevalonate pathway", "Mfap5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement", "Mfap5mediated ovarian cancer cell motility and invasiveness", "Microglia pathogen phagocytosis pathway", "Microrna network associated with chronic lymphocytic leukemia", "Micrornas in cardiomyocyte hypertrophy", "Microtubule cytoskeleton regulation", "Mir124 predicted interactions with cell cycle and differentiation", "Mir517 relationship with arcn1 and usp1", "Mirna biogenesis", "Mirna regulation of dna damage response", "Mirna regulation of p53 pathway in prostate cancer", "Mirna regulation of prostate cancer signaling pathways", "Mirnas involved in dna damage response", "Mirnas involvement in the immune response in sepsis", "Mitochondrial complex i assembly model oxphos system", "Mitochondrial complex ii assembly", "Mitochondrial complex iii assembly", "Mitochondrial complex iv assembly", "Mitochondrial fatty acid synthesis pathway", "Mitochondrial gene expression", "Mitochondrial immune response to sarscov2", "Mitochondrial long chain fatty acid betaoxidation", "Modulators of tcr signaling and t cell activation", "Molybdenum cofactor moco biosynthesis", "Monoamine transport", "Mrna processing", "Mrna protein and metabolite inducation pathway by cyclosporin a", "Mthfr deficiency", "Myd88 distinct inputoutput pathway", "Myometrial relaxation and contraction pathways", "Nad biosynthetic pathways", "Nad metabolism", "Nad metabolism in oncogeneinduced senescence and mitochondrial dysfunctionassociated senescence", "Nad metabolism sirtuins and aging", "Nanomaterial induced apoptosis", "Nanomaterialinduced inflammasome activation", "Nanoparticle triggered autophagic cell death", "Nanoparticle triggered regulated necrosis", "Nanoparticlemediated activation of receptor signaling", "Ncrnas involved in stat3 signaling in hepatocellular carcinoma", "Ncrnas involved in wnt signaling in hepatocellular carcinoma", "Neovascularisation processes", "Nephrotic syndrome", "Netrinunc5b signaling pathway", "Network map of sarscov2 signaling pathway", "Neural crest cell migration during development", "Neural crest cell migration in cancer", "Neural crest differentiation", "Neurodegeneration with brain iron accumulation nbia subtypes pathway", "Neuroinflammation", "Neuroinflammation and glutamatergic signaling", "Nicotine effect on dopaminergic neurons", "Nipbl role in dna damage cornelia de lange syndrome", "Nitric oxide metabolism in cystic fibrosis", "Nocgmppkg mediated neuroprotection", "Nonalcoholic fatty liver disease", "Nongenomic actions of 125 dihydroxyvitamin d3", "Nonhomologous end joining", "Nonsmall cell lung cancer", "Notch signaling", "Notch signaling pathway", "Notch1 regulation of endothelial cell calcification", "Novel intracellular components of rigilike receptor rlr pathway", "Nrf2 pathway", "Nrf2are regulation", "Nrp1triggered signaling pathways in pancreatic cancer", "Nsp1 from sarscov2 inhibits translation initiation in the host cell", "Nuclear receptors in lipid metabolism and toxicity", "Nuclear receptors metapathway", "Nucleotide excision repair", "Nucleotide excision repair in xeroderma pigmentosum", "Nucleotide metabolism", "Nucleotidebinding oligomerization domain nod pathway", "Oligodendrocyte specification and differentiation leading to myelin components for cns", "Omega3 omega6 fatty acid synthesis", "Omega9 fatty acid synthesis", "Oncostatin m signaling pathway", "Onecarbon metabolism", "Onecarbon metabolism and related pathways", "Orexin receptor pathway", "Osteoblast differentiation and related diseases", "Osteoclast signaling", "Osteopontin signaling", "Osx and mirnas in tooth development", "Ovarian infertility", "Overlap between signal transduction pathways contributing to lmna laminopathies", "Overview of interferonsmediated signaling pathway", "Overview of nanoparticle effects", "Overview of proinflammatory and profibrotic mediators", "Oxidation by cytochrome p450", "Oxidative damage response", "Oxidative phosphorylation", "Oxidative stress response", "Oxysterols derived from cholesterol", "P38 mapk signaling pathway", "P53 transcriptional gene network", "Pancreatic adenocarcinoma pathway", "Parkinsons disease pathway", "Parkinubiquitin proteasomal system pathway", "Pathogenesis of sarscov2 mediated by nsp9nsp10 complex", "Pathogenic escherichia coli infection", "Pathways affected in adenoid cystic carcinoma", "Pathways of nucleic acid metabolism and innate immune sensing", "Pdgf pathway", "Pdgfrbeta pathway", "Pentose phosphate metabolism", "Pentose phosphate pathway in senescent cells", "Peroxiredoxin 2 induced ovarian failure", "Phase i biotransformations non p450", "Phosphodiesterases in neuronal function", "Phosphoinositides metabolism", "Photodynamic therapyinduced ap1 survival signaling", "Photodynamic therapyinduced hif1 survival signaling", "Photodynamic therapyinduced nfe2l2 nrf2 survival signaling", "Photodynamic therapyinduced nfkb survival signaling", "Photodynamic therapyinduced unfolded protein response", "Physicochemical features and toxicityassociated pathways", "Physiological and pathological hypertrophy of the heart", "Pi3kakt signaling pathway", "Pi3kaktmtor signaling pathway and therapeutic opportunities", "Pi3kaktmtor vitd3 signaling", "Pilocytic astrocytoma", "Ppar signaling pathway", "Pparalpha pathway", "Praderwilli and angelman syndrome", "Pregnane x receptor pathway", "Preimplantation embryo", "Primary focal segmental glomerulosclerosis fsgs", "Prion disease pathway", "Progeriaassociated lipodystrophy", "Prolactin signaling pathway", "Prostaglandin and leukotriene metabolism in senescence", "Prostaglandin signaling", "Prostaglandin synthesis and regulation", "Proteasome degradation", "Proteoglycan biosynthesis", "Proximal tubule transport", "Ptf1a related regulatory pathway", "Purine metabolism", "Purine metabolism and related disorders", "Purinergic signaling", "Pyrimidine metabolism", "Pyrimidine metabolism and related diseases", "Quercetin and nfkb ap1 induced apoptosis", "Rac1pak1p38mmp2 pathway", "Rala downstream regulated genes", "Ranklrank signaling pathway", "Ras and bradykinin pathways in covid19", "Ras signaling", "Regucalcin in proximal tubule epithelial kidney cells", "Regulation of actin cytoskeleton", "Regulation of apoptosis by parathyroid hormonerelated protein", "Regulation of sister chromatid separation at the metaphaseanaphase transition", "Regulation of wnt bcatenin signaling by small molecule compounds", "Regulatory circuits of the stat3 signaling pathway", "Relationship between inflammation cox2 and egfr", "Reninangiotensinaldosterone system raas", "Resistin as a regulator of inflammation", "Retinoblastoma gene in cancer", "Rett syndrome causing genes", "Riboflavin and coq disorders", "Robo4 and vegf signaling pathways crosstalk", "S1p receptor signal transduction", "Sars coronavirus and innate immunity", "Sarscov2 and covid19 pathway", "Sarscov2 b117 variant antagonises innate immune activation", "Sarscov2 innate immunity evasion and cellspecific immune response", "Sarscov2 replication organelle formation", "Selenium micronutrient network", "Serine metabolism", "Serotonin and anxiety", "Serotonin htr1 group and fos pathway", "Serotonin receptor 2 and elksrfgata4 signaling", "Serotonin receptor 467 and nr3c signaling", "Serotonin transporter activity", "Signal transduction through il1r", "Sleep regulation", "Small cell lung cancer", "Smc1smc3 role in dna damage cornelia de lange syndrome", "Somatroph axis gh and its relationship to dietary restriction and aging", "Sphingolipid metabolism in senescence", "Sphingolipid metabolism integrated pathway", "Sphingolipid metabolism overview", "Sphingolipid pathway", "Spinal cord injury", "Splicing factor nova regulated synaptic proteins", "Srebf and mir33 in cholesterol and lipid homeostasis", "Statin inhibition of cholesterol production", "Steroid biosynthesis", "Sterol regulatory elementbinding proteins srebp signaling", "Sting pathway in kawasakilike disease and covid19", "Striated muscle contraction pathway", "Sudden infant death syndrome sids susceptibility pathways", "Sulfation biotransformation reaction", "Supression of hmgb1 mediated inflammation by thbd", "Synaptic signaling pathways associated with autism spectrum disorder", "Synaptic vesicle pathway", "T cell receptor and costimulatory signaling", "Target of rapamycin tor signaling", "Tca cycle aka krebs or citric acid cycle", "Tca cycle and deficiency of pyruvate dehydrogenase complex pdhc", "Tca cycle in senescence", "Tca cycle nutrient use and invasiveness of ovarian cancer", "Tcell activation sarscov2", "Tcell antigen receptor tcr pathway during staphylococcus aureus infection", "Tcell receptor tcr signaling pathway", "Tgfbeta receptor signaling", "Tgfbeta receptor signaling in skeletal dysplasias", "Tgfbeta signaling in thyroid cells for epithelialmesenchymal transition", "Tgfbeta signaling pathway", "Thermogenesis", "Thiamine metabolic pathways", "Thymic stromal lymphopoietin tslp signaling pathway", "Thyroid hormones production and peripheral downstream signaling effects", "Thyroid stimulating hormone tsh signaling pathway", "Tlr4 signaling and tolerance", "Tnfalpha signaling pathway", "Tnfrelated weak inducer of apoptosis tweak signaling pathway", "Tolllike receptor signaling pathway", "Tolllike receptor signaling related to myd88", "Tp53 network", "Transcription cofactors ski and skil protein partners", "Transcription factor regulation in adipogenesis", "Transcription factors regulate mirnas related to cardiac hypertrophy", "Transcriptional activation by nrf2 in response to phytochemicals", "Translation factors", "Translation inhibitors in chronically activated pdgfra cells", "Transsulfuration and onecarbon metabolism", "Transsulfuration pathway", "Triacylglyceride synthesis", "Tryptophan catabolism leading to nad production", "Tryptophan metabolism", "Tumor suppressor activity of smarcb1", "Type 2 papillary renal cell carcinoma", "Type i collagen synthesis in the context of osteogenesis imperfecta", "Type i interferon induction and signaling during sarscov2 infection", "Type ii diabetes mellitus", "Type ii interferon signaling ifng", "Type iii interferon signaling", "Tyrobp causal network in microglia", "Ultraconserved region 339 modulation of tumor suppressor micrornas in cancer", "Unfolded protein response", "Urea cycle and associated pathways", "Urea cycle and metabolism of amino groups", "Urea cycle and related diseases", "Valproic acid pathway", "Vasopressinregulated water reabsorption", "Vegfavegfr2 signaling pathway", "Vitamin a and carotenoid metabolism", "Vitamin b12 disorders", "Vitamin b12 metabolism", "Vitamin b6dependent and responsive disorders", "Vitamin d in inflammatory diseases", "Vitamin d metabolism", "Vitamin d receptor pathway", "Vitamin dsensitive calcium signaling in depression", "White fat cell differentiation", "Wnt signaling", "Wnt signaling in kidney disease", "Wnt signaling pathway", "Wnt signaling pathway and pluripotency", "Wntbetacatenin signaling pathway in leukemia"], "available_proteins": ["AAR2", "AARS", "AASS", "ABCB1", "ABCD3", "ABCF1", "ABCF2", "ACAA2", "ACACA", "ACACB", "ACAD9", "ACADM", "ACADVL", "ACAT1", "ACAT2", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT8", "ACOT9", "ACOX1", "ACOX3", "ACP1", "ACP6", "ACSL1", "ACSL3", "ACSL4", "ACTN1", "ACTN2", "ACTN4", "ACTR2", "ACTR3", "ADA", "ADAR", "ADH5", "ADI1", "ADK", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGL", "AGPAT1", "AGPS", "AHCTF1", "AHCY", "AHCYL1", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK4", "AKAP12", "AKAP13", "AKAP8", "AKR1A1", "AKR1B1", "AKR7A2", "AKT2", "ALDH18A1", "ALDH2", "ALDH3A2", "ALDH5A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALG1", "AMOT", "ANAPC1", "ANAPC4", "ANAPC5", "ANAPC7", "ANK3", "ANLN", "ANP32A", "ANXA1", "ANXA2", "ANXA6", "AP1G1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "APC", "APEX1", "APMAP", "APP", "APPL1", "APRT", "ARCN1", "ARF4", "ARFGAP1", "ARFIP2", "ARHGDIA", "ARHGEF1", "ARHGEF2", "ARID1A", "ARL2", "ARL3", "ARL8B", "ARMC8", "ARPC1A", "ARPC2", "ARPC3", "ARPC4", "ARPC5", "ASAH1", "ASCC3", "ASF1A", "ASNA1", "ASNS", "ATG7", "ATIC", "ATP1A1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5L", "ATP5O", "ATP6AP1", "ATP6V0D1", "ATP6V1A", "ATP6V1C1", "ATP6V1D", "ATP6V1E1", "ATP6V1H", "ATPAF1", "ATPIF1", "ATXN10", "ATXN2L", "AURKA", "B3GALT6", "BAG2", "BAG4", "BAIAP2", "BAK1", "BANF1", "BAZ1A", "BAZ1B", "BCAS3", "BCL2L13", "BCLAF1", "BCS1L", "BLVRA", "BLVRB", "BPTF", "BRD4", "BRIX1", "BSG", "BTAF1", "BTF3", "BUB1", "BUB1B", "BUB3", "C1QBP", "CACYBP", "CAD", "CALD1", "CALM3", "CALR", "CALU", "CAMK2G", "CAND1", "CAP1", "CAPN1", "CAPNS1", "CAPZB", "CARM1", "CASK", "CASP3", "CASP6", "CASP7", "CASP8", "CBR1", "CBX1", "CBX3", "CBX5", "CCAR2", "CCDC124", "CCDC6", "CCNB1", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2AP", "CD2BP2", "CD47", "CDC16", "CDC23", "CDC27", "CDC37", "CDC40", "CDC42", "CDC45", "CDC73", "CDCA5", "CDIPT", "CDK1", "CDK2", "CDK4", "CDK6", "CDS2", "CDX2", "CEBPZ", "CELF1", "CEP44", "CERS1", "CERS2", "CETN2", "CFL1", "CFL2", "CHAMP1", "CHD1", "CHD4", "CHEK2", "CHKA", "CHMP5", "CHMP6", "CHORDC1", "CHRAC1", "CHST14", "CIP2A", "CISD1", "CKB", "CLASP1", "CLIC1", "CLPTM1L", "CLTA", "CLTC", "CLUH", "CMPK1", "CNN2", "CNOT1", "CNOT9", "CNP", "COA3", "COASY", "COLEC12", "COLGALT1", "COMT", "COPG1", "COPS2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS7A", "COPS7B", "COPS8", "COQ8A", "COQ9", "COX15", "COX2", "COX4I1", "COX5A", "COX5B", "COX6C", "COX7A2", "COX7C", "CPNE1", "CPOX", "CPSF1", "CPSF2", "CPSF3", "CPT1A", "CPT2", "CRKL", "CRTAP", "CS", "CSK", "CSNK1A1", "CSNK2A2", "CSNK2B", "CSTB", "CSTF1", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTNNA1", "CTNNB1", "CTNND1", "CTPS1", "CTPS2", "CTR9", "CTSA", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4A", "CUL4B", "CUL5", "CYB5B", "CYB5R3", "CYC1", "CYFIP1", "CYP20A1", "CYP51A1", "DAGLB", "DARS", "DBNL", "DCAF1", "DCAF7", "DCP1A", "DCTD", "DCTN1", "DCTN2", "DCTN4", "DCTN6", "DCTPP1", "DDAH1", "DDB1", "DDOST", "DDX1", "DDX17", "DDX20", "DDX21", "DDX3X", "DDX5", "DDX52", "DDX56", "DEK", "DERL1", "DFFA", "DHCR24", "DHCR7", "DHFR", "DHX15", "DHX16", "DHX36", "DHX38", "DHX8", "DHX9", "DIABLO", "DIAPH1", "DIAPH3", "DICER1", "DLAT", "DLD", "DLST", "DNAAF5", "DNAJA1", "DNAJB1", "DNAJC3", "DNAJC7", "DNAJC8", "DNM1L", "DNM2", "DNMT1", "DPF2", "DPP9", "DPYSL2", "DSG2", "DSP", "DSTN", "DTYMK", "DUSP3", "DUSP9", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNLL1", "DYNLL2", "EBP", "ECE1", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECSIT", "EEA1", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EFTUD2", "EHD1", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF4A1", "EIF4A2", "EIF4B", "EIF4E", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAVL1", "ELOB", "ELOC", "ELP3", "EMD", "EML4", "ENAH", "ENO1", "EPB41", "EPB41L2", "EPB41L3", "EPHX1", "EPHX2", "EPRS", "EPS15", "EPS15L1", "ERCC2", "ERCC3", "ESD", "ETF1", "ETFA", "ETFDH", "EWSR1", "EXO1", "EXOC1", "EXOC2", "EXOC4", "EXOC5", "EXOC7", "EXOSC4", "EXOSC7", "EZR", "F11R", "FABP5", "FADS2", "FAF1", "FAH", "FAM120A", "FAM91A1", "FANCI", "FARSB", "FASN", "FAU", "FDFT1", "FDPS", "FECH", "FEN1", "FGFR1OP", "FH", "FHL1", "FHOD1", "FIS1", "FKBP10", "FKBP1A", "FKBP4", "FKBP5", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FMR1", "FOXC1", "FOXRED1", "FSCN1", "FTO", "FUCA1", "FUS", "FXR1", "FXR2", "G3BP1", "G6PD", "GABARAPL2", "GAPDH", "GART", "GBA", "GBE1", "GCC2", "GCDH", "GCLM", "GDAP1", "GDI1", "GFPT1", "GGCT", "GGCX", "GGH", "GIGYF2", "GLA", "GLB1", "GLS", "GLUD1", "GM2A", "GMPPB", "GNA13", "GNAI1", "GNAI2", "GNAI3", "GNS", "GOT1", "GOT2", "GPAM", "GPD2", "GPHN", "GPI", "GPS1", "GPT2", "GRB2", "GRSF1", "GSK3A", "GSK3B", "GSR", "GSS", "GSTK1", "GSTM3", "GSTO1", "GSTZ1", "GTF2B", "GTF2E1", "GTF2F2", "GTF2I", "GTPBP4", "GUSB", "GYG1", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HADH", "HADHA", "HADHB", "HAT1", "HCFC1", "HDAC2", "HDGF", "HEBP1", "HELLS", "HEXA", "HEXB", "HGS", "HIBADH", "HIBCH", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HLTF", "HMBS", "HMGA1", "HMGB1", "HMGB2", "HMGCL", "HMGCS1", "HMOX1", "HNRNPA1", "HNRNPA2B1", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPK", "HNRNPL", "HNRNPM", "HNRNPR", "HNRNPU", "HPRT1", "HS2ST1", "HSD17B10", "HSD17B12", "HSD17B4", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA14", "HSPA1B", "HSPA2", "HSPA4", "HSPA8", "HSPA9", "HSPB1", "HSPD1", "HTT", "HUS1", "HYOU1", "IARS", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDI1", "IFT27", "IGBP1", "IGF2BP1", "IGF2BP3", "ILF2", "ILK", "IMP3", "IMPDH1", "IMPDH2", "INF2", "IPO9", "IQGAP1", "IRS4", "ITCH", "ITGB1", "ITPA", "IVD", "JUP", "KAT7", "KDM1A", "KDM1B", "KDM3B", "KDSR", "KHDRBS1", "KHSRP", "KIF22", "KIF23", "KIF2C", "KIF3A", "KIF4A", "KIF5B", "KLC1", "KLC2", "KLC4", "KPNA1", "KPNB1", "KTN1", "L2HGDH", "LARP1", "LARP7", "LARS2", "LBR", "LDHA", "LDHB", "LDLR", "LEMD3", "LGALS3", "LGALS3BP", "LIG1", "LIG3", "LIPA", "LLGL1", "LMAN1", "LMNA", "LMNB1", "LMNB2", "LPP", "LRPPRC", "LRRC59", "LSM7", "LSS", "LTA4H", "LZTFL1", "MACF1", "MAD1L1", "MAD2L1", "MAGT1", "MAP1B", "MAP2K1", "MAP2K2", "MAP2K3", "MAP4", "MAPK1", "MAPK14", "MAPRE1", "MAPRE2", "MARCKS", "MARS", "MARS2", "MAT2A", "MAT2B", "MAU2", "MAVS", "MBNL1", "MCAT", "MCCC1", "MCCC2", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCU", "MDC1", "MDH1", "MDH2", "ME2", "MECP2", "MED1", "MFAP1", "MFN2", "MGST2", "MGST3", "MIA3", "MIF", "MKI67", "MMAB", "MOGS", "MORF4L1", "MOV10", "MPDU1", "MPI", "MPP1", "MPP2", "MPST", "MRE11", "MRPL19", "MRPL40", "MSH2", "MSH3", "MSH6", "MSMO1", "MSN", "MTA1", "MTA2", "MTAP", "MTCH1", "MTDH", "MTHFD1", "MTHFD1L", "MTHFD2", "MTOR", "MTR", "MUT", "MYBBP1A", "MYCBP", "MYEF2", "MYH10", "MYH9", "MYL6", "MYO6", "NAA15", "NAA40", "NAA50", "NAE1", "NAGLU", "NAMPT", "NAP1L1", "NAPA", "NARS", "NAT10", "NBN", "NCAPG", "NCBP1", "NCBP2", "NCDN", "NCKAP1", "NCL", "NCSTN", "NDUFA10", "NDUFA11", "NDUFA13", "NDUFA2", "NDUFA4", "NDUFA5", "NDUFA7", "NDUFA8", "NDUFA9", "NDUFAF4", "NDUFAF7", "NDUFB10", "NDUFB11", "NDUFB3", "NDUFB4", "NDUFB5", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS7", "NDUFS8", "NDUFV1", "NDUFV2", "NEFL", "NEFM", "NEK9", "NELFA", "NELFCD", "NELFE", "NFKB1", "NKRF", "NME1", "NME2", "NONO", "NOP2", "NPC1", "NSDHL", "NSF", "NUBPL", "NUDC", "NUDT21", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP214", "NUP62", "NUP88", "NUP98", "NXF1", "OAT", "OCLN", "OGDH", "OGT", "OPA1", "P3H1", "P4HA1", "P4HA2", "P4HB", "PABPC1", "PABPN1", "PAF1", "PAFAH1B1", "PAICS", "PAK1", "PAK2", "PAPSS1", "PARK7", "PARN", "PARP1", "PARP2", "PBK", "PBRM1", "PC", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCK2", "PCM1", "PCNA", "PDCD4", "PDCD6", "PDCD6IP", "PDE12", "PDE4DIP", "PDE6D", "PDHA1", "PDHB", "PDIA3", "PDIA6", "PDLIM5", "PDLIM7", "PDS5A", "PDS5B", "PEBP1", "PECR", "PELO", "PFAS", "PFDN2", "PFDN4", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGRMC2", "PHB", "PHB2", "PHF5A", "PHF6", "PHF8", "PHGDH", "PI4K2A", "PIK3C3", "PIN1", "PIP4K2C", "PISD", "PKM", "PKMYT1", "PKN1", "PKN2", "PLCG1", "PLEC", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PMPCA", "PNP", "PNPLA8", "PNPT1", "POLA1", "POLA2", "POLD1", "POLDIP2", "POLE", "POLE3", "POLE4", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2A", "POLR2B", "POLR2C", "POLR2E", "POLR2G", "POLR2L", "POLR3A", "POLRMT", "PON2", "POR", "PPAT", "PPIB", "PPID", "PPIF", "PPM1G", "PPOX", "PPP1CA", "PPP1CB", "PPP1R10", "PPP1R12A", "PPP1R7", "PPP1R8", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP4R3A", "PPP5C", "PPT2", "PRCC", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PRIM1", "PRIM2", "PRKACA", "PRKAG1", "PRKAR1A", "PRKAR2A", "PRKDC", "PRKRA", "PRMT1", "PRMT3", "PRMT5", "PRPF3", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPS2", "PRRC2C", "PSAT1", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD6", "PSMD7", "PSMD8", "PSME1", "PSME2", "PSME3", "PSPC1", "PTBP1", "PTBP2", "PTDSS1", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTPA", "PTPN1", "PTRH2", "PURA", "PXMP2", "PYCR1", "PYCR2", "PYGB", "PYGL", "QKI", "RAB10", "RAB11B", "RAB13", "RAB14", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RAB8A", "RAB8B", "RAB9A", "RABGAP1", "RAC1", "RACK1", "RAD21", "RAD23A", "RAD23B", "RAD50", "RAD9A", "RAE1", "RALA", "RALB", "RAN", "RANBP1", "RANBP9", "RANGAP1", "RAPGEF2", "RARS", "RBM14", "RBM17", "RBM39", "RBM4", "RBM4B", "RBM5", "RBMX", "RBPMS", "RCC1", "RCN1", "RDH14", "RDX", "RECQL", "RETSAT", "REXO2", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RHEB", "RHOA", "RHOG", "RIF1", "RIPK1", "RNASEH2A", "RNASET2", "RNF14", "RNF20", "RNF40", "RNPS1", "ROCK2", "RP2", "RPA1", "RPA2", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPN1", "RPN2", "RPRD1B", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RRBP1", "RRM1", "RRM2", "RTCB", "RTN3", "RTN4", "RUVBL1", "S100A10", "S100A11", "SACM1L", "SAFB", "SAMHD1", "SAP18", "SAR1A", "SARS", "SC5D", "SCAMP2", "SCARB1", "SCARB2", "SCD", "SCO1", "SCO2", "SCP2", "SCRIB", "SDHA", "SDHB", "SEC23A", "SEC23B", "SEC24A", "SEC24B", "SEC24C", "SEC31A", "SEL1L", "SEPT11", "SERBP1", "SERPINB6", "SERPINH1", "SET", "SETD2", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SFPQ", "SFSWAP", "SGPL1", "SH3BGRL3", "SH3GL1", "SH3GLB1", "SHMT1", "SHMT2", "SHOC2", "SIRT1", "SKP1", "SKP2", "SLC16A1", "SLC19A1", "SLC1A5", "SLC25A1", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A20", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A4", "SLC29A1", "SLC2A1", "SLC33A1", "SLC35B2", "SLC3A2", "SLC7A1", "SLIT2", "SLTM", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCC1", "SMARCC2", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMYD3", "SMYD4", "SNAP23", "SNAP29", "SND1", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNU13", "SNW1", "SOAT1", "SOD2", "SORT1", "SPEN", "SPPL2A", "SPTAN1", "SPTBN1", "SPTLC1", "SPTLC2", "SQLE", "SQSTM1", "SREK1", "SRM", "SRP54", "SRPK1", "SRRM1", "SRSF1", "SRSF10", "SRSF3", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSNA1", "SSR4", "STAG1", "STAG2", "STAM", "STAMBP", "STAT1", "STAT3", "STIP1", "STK4", "STMN1", "STOM", "STRAP", "STRN", "STUB1", "STXBP3", "STXBP4", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGP2", "SUGT1", "SUN1", "SUPT5H", "SUZ12", "SYNE2", "TALDO1", "TARDBP", "TBC1D4", "TBCA", "TCP1", "TDP2", "TECR", "TELO2", "TERF2IP", "TFAM", "TFCP2", "TFRC", "THRAP3", "TIGAR", "TIPRL", "TJP1", "TK1", "TKFC", "TKT", "TLN1", "TMED10", "TMEM165", "TMEM43", "TMOD1", "TMOD3", "TMPO", "TMPO", "TNKS1BP1", "TNPO1", "TOLLIP", "TOMM40", "TOMM70", "TOP1", "TOP2A", "TOR1AIP1", "TP53", "TP53BP1", "TPI1", "TPM1", "TPM3", "TPM4", "TPP1", "TPX2", "TRA2A", "TRA2B", "TRAM1", "TRAP1", "TRIM25", "TRIM28", "TRIM33", "TRIM35", "TRIP13", "TSG101", "TTC19", "TTC26", "TTF2", "TUBB", "TUBB2A", "TUBB2B", "TUBB4A", "TUBB4B", "TUBB6", "TUBGCP2", "TUBGCP3", "TUFM", "TXNDC5", "TXNRD1", "TYMS", "U2AF1", "U2AF2", "UBA1", "UBA3", "UBAP2L", "UBE2G2", "UBE2L3", "UBE2N", "UBE3A", "UBR5", "UBTF", "UCHL5", "UFD1", "UGDH", "UGGT1", "UGP2", "UHRF1", "UMPS", "UNC119", "UNG", "UPF1", "UQCC1", "UQCR10", "UQCRB", "UQCRC1", "UQCRC2", "UQCRQ", "UROD", "USMG5", "USP10", "USP5", "USP7", "USP9X", "UTRN", "VANGL1", "VAPA", "VAPB", "VARS1", "VBP1", "VCL", "VDAC1", "VDAC2", "VDAC3", "VIM", "VMP1", "VPS18", "VPS33A", "WAPL", "WARS", "WDHD1", "WDR1", "WDR5", "WFS1", "WIPI2", "WNK1", "XAB2", "XPNPEP3", "XPO1", "XPO5", "XRCC1", "XRCC5", "XRCC6", "XRN2", "YARS", "YARS2", "YBX1", "YBX3", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZC3H15", "ZFR", "ZFYVE16", "ZMPSTE24", "ZNF281", "ZNF318", "ZYX"], "leading_proteins": ["ABCB1", "ACAD9", "ACAT2", "ACOX1", "ACOX3", "ACP6", "ACSL4", "ADA", "ADK", "AHCYL1", "AKT2", "ALDH3A2", "AMOT", "APC", "APP", "ATP2A2", "ATP2B1", "ATP5L", "BAIAP2", "BCL2L13", "BCLAF1", "BLVRB", "CAMK2G", "CASP3", "CASP7", "CCNB1", "CDC37", "CDCA5", "CDK4", "CERS1", "CERS2", "CHAMP1", "CHKA", "CHST14", "CISD1", "CLUH", "COA3", "COMT", "COPS6", "COX4I1", "COX7A2", "CPSF3", "CPT2", "CSNK1A1", "CSTF1", "CTBP1", "CYB5B", "CYP20A1", "CYP51A1", "DERL1", "DHCR24", "DHCR7", "DICER1", "EBP", "ECE1", "EIF4E", "EMD", "EPHX1", "FDFT1", "FGFR1OP", "FKBP1A", "FOXRED1", "FUS", "FXR1", "G6PD", "GBA", "GLUD1", "GNAI2", "GNAI3", "GPAM", "GPD2", "GRB2", "GSK3B", "GSR", "GUSB", "GYG1", "HADH", "HADHA", "HEBP1", "HLA-B", "HMGB1", "HMOX1", "HNRNPA1", "HNRNPA2B1", "HNRNPAB", "HNRNPD", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPK", "HNRNPM", "HNRNPR", "HSD17B4", "ICMT", "KDM1A", "KDSR", "KLC2", "LBR", "LSS", "LTA4H", "MAP2K1", "MAP2K2", "MAPK1", "MAPK14", "MAVS", "MCL1", "MCM3", "MCM6", "MED1", "MMAB", "MPP1", "MPP2", "MSMO1", "MTAP", "MTDH", "MTOR", "MTR", "NAGLU", "NAMPT", "NAP1L1", "NDUFA11", "NDUFA13", "NDUFAF7", "NDUFB10", "NDUFB11", "NDUFB3", "NDUFB4", "NDUFB9", "NDUFS2", "NEFL", "NEFM", "NONO", "NPC1", "OPA1", "PAK1", "PBK", "PCM1", "PDE6D", "PECR", "PFDN2", "PFDN4", "PFDN6", "PIK3C3", "PIP4K2C", "PKM", "PKMYT1", "PMPCA", "POLA2", "PON2", "POR", "PRKACA", "PRKAG1", "PRMT1", "PSMB1", "PSMB2", "PSMB4", "PSMB6", "PSMB7", "PSMD3", "PSMD8", "PTPA", "PYGL", "RAB8A", "RBM4", "RBM4B", "RBMX", "RIPK1", "RNPS1", "RPA2", "RRM2", "RTN3", "RTN4", "SCARB1", "SCARB2", "SCD", "SCO2", "SDHB", "SFPQ", "SGPL1", "SIRT1", "SLC19A1", "SLC25A15", "SLC25A20", "SLC2A1", "SLC35B2", "SLC3A2", "SMYD4", "SORT1", "SPTLC1", "SQLE", "SRSF1", "SRSF3", "SRSF9", "STAT1", "SUZ12", "TFAM", "TMPO", "TOMM40", "TRA2B", "TRAM1", "TRIM35", "TTC26", "TUBGCP2", "TUBGCP3", "TYMS", "UBE3A", "UNC119", "UQCC1", "UQCR10", "UQCRC1", "UQCRC2", "UQCRQ", "USMG5", "VANGL1", "VBP1", "VDAC1", "VDAC2", "VDAC3", "VIM", "VMP1", "XPO5", "YBX1", "ZMPSTE24"]} \ No newline at end of file diff --git a/opencell_localization/advanced/idx2term.json b/opencell_localization/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..16394af118812334afd67d06e09a1af065a2166f --- /dev/null +++ b/opencell_localization/advanced/idx2term.json @@ -0,0 +1 @@ +{"0": "er", "1": "mitochondria"} \ No newline at end of file diff --git a/opencell_localization/advanced/plot_0.png 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pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +er 32 84 4.403689488691017 1.0642524155501931e-05 29.17233009708738 87.61893203883496 1.3358083950399515 0.3757472714196316 13.465054065187209 8.223393744963309 2.0429537263872786 0.4010648005920765 2.891136466583301e-07 0.0005688844413166 6.840473961893495e-05 8.548982321199652e-09 4.174273445974064e-15 +mitochondria 5 11 2.156683942781376 0.0310302989534494 4.441747572815534 10.567961165048544 1.1937677940164793 0.2159787381789819 2.254231157409949 0.7391563798220593 1.4011905974754153 0.2980089661914649 0.0226231574063278 0.0017062060788896 0.0067896670197663 0.0382400085743442 1.665940864684324e-05 diff --git a/opencell_localization/metrics.json b/opencell_localization/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..d7a1d8fa3f8e9d6bbcd3f27cf7823875cc553ec9 --- /dev/null +++ b/opencell_localization/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2734, + "annotations_size": 17, + "title": "Average number of proteins per term", + "value": 87.47058823529412 +} \ No newline at end of file diff --git a/opencell_localization/paths.json b/opencell_localization/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..557a1cf429ce6387ede719848f27cc308f1b8fc0 --- /dev/null +++ b/opencell_localization/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/opencell_localization/fragment/C166/C166_val_log2fc"} \ No newline at end of file diff --git a/opencell_localization/result.tsv b/opencell_localization/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..77da96bbcef3d56f748de578826e5a5a4967bf23 --- /dev/null +++ b/opencell_localization/result.tsv @@ -0,0 +1,6 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +er 0.5945250544300423 4.403689488691017 1.0642524155501931e-05 0.0001809075076516 0.0001809229106435 84 O00264,Q16850,Q99640,Q8TBX8,Q9Y3E0,O75845,Q9Y487,Q00765,Q969V3,Q9NQC3,Q96A33,O95470,Q15392,Q06136,Q9NR31,Q07065,Q13190,Q9UM00,Q15125,Q96N66,Q96GC9,P48651,O15173,Q9Y5M8,O96005,Q9P2W9,Q14739,P48449,O15269,P46977,O00767,P51572 32 +mitochondria 0.7375038170238867 2.156683942781376 0.0310302989534494 0.4148417230470462 0.2400583847452348 11 Q9Y277,P21796,Q9NR31,P45880,Q8IWA4 5 +vesicles 0.3418394044886217 1.8080070247043591 0.0706054072780102 0.7119934241937048 0.2400583847452348 156 O00264,Q8NEB9,Q8IXU6,Q9Y3E0,O75845,P41440,P17812,Q5VW38,Q9NPI6,Q93050,P11166,Q969V3,O95470,Q15392,Q06136,Q10713,O15127,Q9UM00,Q15125,O15400,P50570,P30825,P22059,O15173,O96005,P31751,Q7Z6M1,O15126,O15027,P48449,O15269,O00767,Q9UEU0 33 +golgi 0.4038963206629909 1.634901803525708 0.1020696343533069 0.8396292373116352 0.2891972973343697 52 Q8IXU6,Q9Y3E0,O15126,Q9NR31,P22059,Q8IZA0,P35606,O15127,Q9NTJ5,Q5VW38,Q9Y487,Q13190,Q9UM00 13 +membrane 0.2610672902106391 0.1732399653728827 0.8624628107149843 0.9999999999999978 0.9163667363846708 70 Q9NQC3,Q8TBX8,P48729,Q9UQB8,O15126,P30825,P25054,P22059,P41440,Q68EM7,O15127,P31751,P08670 13 diff --git a/opencell_localization/selections.json b/opencell_localization/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..3f318eae9daa32faa644b189755e547ae6c6c23f --- /dev/null +++ b/opencell_localization/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["big_aggregates", "cell_contact", "centrosome", "chromatin", "cytoplasmic", "cytoskeleton", "er", "focal_adhesions", "golgi", "membrane", "mitochondria", "nuclear_membrane", "nuclear_punctae", "nucleolus_fc_dfc", "nucleolus_gc", "nucleoplasm", "vesicles"], "available_proteins": ["AATF", "ABCE1", "ACLY", "ACTN1", "ACTN4", "ACTR2", "AHCY", "AHSA1", "AKAP12", "AKAP13", "AKAP8L", "AKR1A1", "AKT2", "ALDH9A1", "ANAPC16", "ANAPC4", "ANXA11", "AP2B1", "AP2S1", "APC", "APPL1", "ARF4", "ARF5", "ARFGAP1", "ARFIP1", "ARFIP2", "ARHGAP17", "ARID1A", "ARL1", "ARL2", "ARL3", "ARL6IP1", "ARL6IP5", "ARL8B", "ARPC2", "ARPC3", "ATG7", "ATL2", "ATP1A1", "ATP2B1", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1D", "ATP6V1E1", "ATP6V1H", "ATXN10", "ATXN2L", "BAG4", "BAG6", "BAIAP2", "BANF1", "BAZ1A", "BAZ1B", "BCAP31", "BLVRA", "BLVRB", "BMS1", "BNIP1", "BOP1", "BPNT1", "BRD4", "BTF3", "BUB1", "BUB1B", "BYSL", "CAD", "CALD1", "CALM3", "CAMK2G", "CANX", "CAPRIN1", "CAPZB", "CASP3", "CASP6", "CASP7", "CBX1", "CCAR1", "CCDC22", "CCDC47", "CCDC86", "CCDC93", "CCNB1", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2BP2", "CDC16", "CDC23", "CDC27", "CDC37", "CDC42", "CDIPT", "CDK1", "CDK12", "CDK2", "CDK4", "CDS2", "CETN2", "CHEK2", "CHMP1A", "CHMP2B", "CHMP6", "CHMP7", "CKAP2", "CKAP4", "CKAP5", "CKB", "CLASP1", "CLINT1", "CLNS1A", "CLPTM1", "CLTA", "CLTC", "CNN2", "COIL", "COMMD4", "COPA", "COPB2", "COPE", "COPG1", "COPG2", "COPZ1", "CORO1B", "CORO1C", "CPSF6", "CSE1L", "CSK", "CSNK1A1", "CSNK2A2", "CSNK2B", "CTBP1", "CTBP2", "CTNNB1", "CTNNBL1", "CTPS1", "CTTN", "CYB5R3", "CYP51A1", "DAD1", "DBNL", "DCP1A", "DCTN2", "DDB1", "DDOST", "DDX21", "DDX39B", "DDX47", "DDX5", "DDX56", "DDX6", "DHCR24", "DHX37", "DHX9", "DIAPH1", "DKC1", "DNAJA1", "DNAJA2", "DNAJB1", "DNAJC11", "DNAJC2", "DNAJC7", "DNAJC8", "DNAJC9", "DNM1L", "DNM2", "DOCK7", "DPH2", "DRG1", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNLL1", "DYNLL2", "EBNA1BP2", "EBP", "EDC3", "EDC4", "EDF1", "EEA1", "EEF1G", "EFTUD2", "EIF2AK2", "EIF3B", "EIF3E", "EIF3G", "EIF3I", "EIF3K", "EIF3M", "EIF4A1", "EIF4A3", "EIF5", "EMC1", "EMC2", "EMC3", "EMC4", "EMG1", "ENO1", "EPS15", "ESD", "ESYT1", "EWSR1", "EZR", "FAM120A", "FAM50A", "FASN", "FAU", "FBL", "FDPS", "FKBP5", "FKBP8", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAPDH", "GAR1", "GBF1", "GDI1", "GDI2", "GET4", "GNL2", "GNL3", "GOLT1B", "GORASP2", "GPR107", "GRB2", "GSK3A", "GSK3B", "GSPT1", "GTF2F1", "GTPBP4", "GYG1", "H1F0", "HDAC2", "HEATR3", "HGS", "HLA-A", "HMGA1", "HMGB2", "HMGCS1", "HNRNPA0", "HNRNPC", "HNRNPD", "HNRNPH1", "HNRNPL", "HNRNPU", "HSP90AA1", "HSP90AB1", "HSPA14", "HSPA1B", "HSPA4", "HSPA4L", "HSPA8", "HSPB1", "HSPBP1", "HSPH1", "HUS1", "IDI1", "IGF2BP1", "IGF2BP3", "ILF3", "ILK", "IMP3", "INTS14", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IST1", "KDSR", "KIAA0319L", "KIAA0368", "KIF11", "KIF20A", "KIF22", "KIF2A", "KIF2C", "KIF3A", "KIF4A", "KIF5B", "KIFBP", "KIFC1", "KLC1", "KLC2", "KLC4", "KPNA1", "KPNA2", "KPNA3", "KPNA6", "KPNB1", "LAMP1", "LAMP2", "LARP7", "LBR", "LDHA", "LDHB", "LEMD2", "LEMD3", "LIG1", "LMAN1", "LMNA", "LMNB1", "LNPK", "LPCAT1", "LSS", "LTV1", "MAP2K1", "MAP2K2", "MAP2K3", "MAP4", "MAPK1", "MAPK14", "MAPRE1", "MBOAT7", "MDH1", "MECP2", "MED24", "MFN1", "MFN2", "MIF", "MKI67", "MPHOSPH10", "MRTO4", "MSH6", "MSN", "MTOR", "MYBBP1A", "MYH10", "MYH9", "MYL6", "MYO1B", "MYO6", "NAF1", "NANS", "NAPA", "NAPG", "NCAPH", "NCKAP1", "NCL", "NCLN", "NECAP2", "NEK9", "NEMF", "NFKB1", "NHP2", "NIFK", "NMD3", "NOL10", "NOL11", "NONO", "NOP10", "NOP2", "NOP58", "NPM1", "NRBP1", "NSA2", "NSDHL", "NUCKS1", "NUFIP2", "NUMA1", "NUP107", "NUP153", "NUP155", "NUP214", "NUP35", "NUP98", "NUTF2", "NVL", "NXF1", "OSBP", "OSBPL11", "OSBPL8", "PABPC4", "PACSIN2", "PACSIN3", "PAK1", "PAK2", "PARP1", "PASK", "PBK", "PCNA", "PDAP1", "PDCD11", "PDCD6", "PDCD6IP", "PDCL3", "PES1", "PFDN6", "PFN1", "PGK1", "PGRMC1", "PGRMC2", "PHGDH", "PI4K2A", "PI4KB", "PICALM", "PIK3C3", "PIN4", "PIP4K2C", "PKM", "PKMYT1", "PKN1", "PKN2", "PLK1", "PMPCA", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2A", "POLR2B", "POLR2C", "POLR2E", "POLR2G", "POLR3A", "PPM1G", "PRKACA", "PRKDC", "PRMT9", "PRPF19", "PRPF4B", "PRPF8", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD12", "PSMD13", "PSMD2", "PSMD3", "PSMD4", "PSMD6", "PSMD7", "PSME1", "PSME2", "PSME3", "PSME4", "PSMF1", "PSMG1", "PSMG3", "PSPC1", "PTDSS1", "PTGES3", "PTK7", "RAB10", "RAB11B", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB1B", "RAB24", "RAB3GAP2", "RAB5A", "RAB5B", "RAB7A", "RAB8B", "RAB9A", "RABEP1", "RABEPK", "RABGAP1", "RAC1", "RACK1", "RAD21", "RAN", "RANBP1", "RANBP2", "RANBP9", "RBM10", "RBM12", "RBM12B", "RBM14", "RBM17", "RBM19", "RBM22", "RBM25", "RBM28", "RBM3", "RBM34", "RBM39", "RBM4", "RBM42", "RBM5", "RBM8A", "RBMX", "REEP5", "RER1", "RHEB", "RHOA", "RHOG", "RNASEH2A", "RNF40", "RPL10A", "RPL11", "RPL13", "RPL19", "RPL27", "RPL35", "RPL4", "RPL5", "RPN1", "RPN2", "RPP30", "RPS11", "RPS14", "RPS16", "RPS18", "RPS6KA1", "RPS6KA3", "RRP1", "RSL1D1", "RTCB", "RTN4", "RUVBL1", "RUVBL2", "S100A10", "SACM1L", "SAE1", "SAR1A", "SARS", "SBDS", "SC5D", "SCAMP1", "SCAMP2", "SCD", "SCFD1", "SEC16A", "SEC22B", "SEC23A", "SEC23B", "SEC24C", "SEC31A", "SEC61B", "SEPT11", "SEPT2", "SEPT7", "SEPT9", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SGPL1", "SH3GL1", "SH3GLB1", "SH3GLB2", "SLC16A1", "SLC19A1", "SLC1A5", "SLC25A17", "SLC27A4", "SLC2A1", "SLC33A1", "SLC35F2", "SLC7A1", "SLC9A3R1", "SLK", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCC1", "SMARCC2", "SMARCE1", "SMC1A", "SMN1*", "SNRNP40", "SNRPA", "SNRPB2", "SNRPC", "SNRPD2", "SNU13", "SNX1", "SNX12", "SNX17", "SNX2", "SNX27", "SNX3", "SNX5", "SNX9", "SPOUT1", "SPPL2A", "SPTLC1", "SPTLC2", "SQSTM1", "SRI", "SRP14", "SRP54", "SRP68", "SRP72", "SRP9", "SRPRA", "SRPRB", "SSB", "SSRP1", "STAG1", "STAG2", "STAM", "STIP1", "STK4", "STT3A", "STX12", "STX18", "STX5", "STX7", "SUPT16H", "SUPT5H", "SYAP1", "TARDBP", "TCOF1", "TFRC", "TIA1", "TJP1", "TMA16", "TMCO1", "TMED10", "TMED2", "TMEM192", "TMPO", "TMPO", "TNPO1", "TNPO3", "TOLLIP", "TOMM20", "TOMM70", "TOP1", "TOP2A", "TOR1AIP1", "TPR", "TPT1", "TRIM24", "TRIM28", "TRIM33", "TRIR", "TRMT1L", "TSG101", "TSR1", "TUBB4B", "U2AF2", "U2SURP", "UBA1", "UBE2M", "UBTF", "UFC1", "UGDH", "UPF1", "USP10", "USP7", "UTP14A", "UTP4", "UTP6", "UTRN", "VAPA", "VAPB", "VCL", "VCP", "VDAC1", "VDAC2", "VDAC3", "VIM", "VMP1", "VPS18", "VPS29", "VPS33A", "VPS35", "VTI1B", "WAPL", "WBP2", "WDR3", "WDR46", "WDR75", "WNK1", "XPO1", "XPO5", "XPOT", "YKT6", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZNF326", "ZYX"], "leading_proteins": ["AKT2", "APC", "ARHGAP17", "ATP6V0A1", "ATP6V0A2", "BAIAP2", "BCAP31", "CCDC47", "CKAP4", "CLPTM1", "COPB2", "CSNK1A1", "CTPS1", "CYP51A1", "DCP1A", "DHCR24", "DNM2", "EBP", "GOLT1B", "GPR107", "KDSR", "KIAA0319L", "LBR", "LSS", "MBOAT7", "MFN1", "NCLN", "OSBP", "PGRMC1", "PGRMC2", "PIK3C3", "PIP4K2C", "PKMYT1", "PMPCA", "PTDSS1", "RABEPK", "REEP5", "RTN4", "SACM1L", "SAR1A", "SC5D", "SCAMP1", "SCAMP2", "SCD", "SEC16A", "SGPL1", "SLC19A1", "SLC2A1", "SLC35F2", "SLC7A1", "SPTLC1", "SRPRB", "STT3A", "STX18", "STX5", "STX7", "TMCO1", "VDAC1", "VDAC2", "VDAC3", "VIM", "VMP1", "VTI1B"]} \ No newline at end of file diff --git a/panther_protein_class/advanced/idx2term.json 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b/panther_protein_class/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:cd3a469ceec3addd83c0de8c95628f6d275699eb9e713d5c32f0f07d9079d161 +size 79315 diff --git a/panther_protein_class/df_merge.tsv b/panther_protein_class/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..755917d38a8c71eb14066e5830dab8fa5a99a49a --- /dev/null +++ b/panther_protein_class/df_merge.tsv @@ -0,0 +1,9 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +transporter 15 54 2.778748156490583 0.0054568814274909 16.281553398058254 57.34708737864078 1.7781248355514696 0.2510912048406951 6.627271511266295 3.5084386843827997 1.4364723564792363 0.3433005081320681 5.280411388018128e-05 0.0185012393708632 0.0055454664314879 0.0005338046281504 0.0001677885228518 +metalloprotease 8 27 2.758777145378686 0.0058018085548012 8.58495145631068 26.398058252427184 1.4262736372921438 0.246779453311036 3.321022586051017 1.6463540525991265 1.1083706824215755 0.2918245458017476 0.0004243155896902 0.2295798469686227 0.0154029461510805 4.204252026569053e-05 0.0002385246399813 +primary active transporter 7 17 2.6827909862282397 0.0073010605024823 8.614077669902912 23.45631067961165 1.2392440710771837 0.271771563990288 4.792195908457348 3.1431129799052804 1.4794913205770832 0.3014776193450941 0.0053460623984832 0.2588687133858448 0.1215022402141297 0.0168986737095617 0.0100404750036471 +oxidoreductase 12 42 2.454469059894601 0.0141092805666269 12.558252427184469 43.60436893203884 0.9664652969079414 0.3656199292680728 5.072676172192643 3.8442089013841825 1.3118377214144643 0.3470065139863294 0.0003312750035242 0.0010872895634474 0.000311534568034 0.0004757717240761 0.0001913464718426 +membrane trafficking regulatory protein 4 17 2.4440875062395246 0.0145219037820634 4.949029126213592 18.78640776699029 1.0645815505395402 0.2320552342124929 2.3097144002673033 2.893415643517755 1.4460865220385617 0.2677048300346334 0.0721207405304943 0.0266825716175236 0.0935352604171004 0.0390247080582918 0.043045103354355 +oxygenase 4 7 2.152773239356395 0.031336504273959 3.138349514563106 6.771844660194175 1.5409868347565758 0.1477866581414416 1.2914149665013366 1.041089559555361 1.2379399582807478 0.2357869798067575 0.0008560924211317 0.1093006244161378 0.0015498580582828 0.0002335266734922 0.0053032680205866 +secondary carrier transporter 3 9 2.072752728073675 0.0381952978550725 6.104368932038835 14.6626213592233 1.264699085385324 0.2718921136589474 3.483843477892234 2.781747184831951 1.2916784116683784 0.322278600042778 0.1396982799773024 1.0 0.1512044234932328 0.2468458051395524 0.4577079609151116 +transmembrane signal receptor 4 6 1.997382650467631 0.0457836310589978 3.266990291262136 7.169902912621359 1.6693846681257831 0.1085289610325799 1.5770125590990791 1.7927217985188668 1.0928815816574815 0.16461969248918 0.5028905058437084 1.0 0.2246728541934789 0.3859684085300801 0.4676307579057312 diff --git a/panther_protein_class/metrics.json b/panther_protein_class/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..793e313d436e9725c77199279c1a4296d365d4c0 --- /dev/null +++ b/panther_protein_class/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2734, + "annotations_size": 158, + "title": "Average number of proteins per term", + "value": 12.069620253164556 +} \ No newline at end of file diff --git a/panther_protein_class/paths.json b/panther_protein_class/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..a49e355bfd8dcd0664c8fb1173eafa633588466c --- /dev/null +++ b/panther_protein_class/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/panther_protein_class/fragment/C166/C166_val_log2fc"} \ No newline at end of file diff --git a/panther_protein_class/result.tsv b/panther_protein_class/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..24df0d53c991ef364a50e91f1c903ae967e54942 --- /dev/null +++ b/panther_protein_class/result.tsv @@ -0,0 +1,43 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +G-protein coupled receptor 0.9783135589411964 2.8362279608900085 0.004564984978387 0.5146664740062117 0.0450792266615725 3 Q5VW38 1 +transporter 0.5131432809523125 2.778748156490583 0.0054568814274909 0.5787582093189579 0.0507168979731507 54 Q99595,Q15070,O60830,Q8N1F7,O43772,P41440,Q9H2D1,Q8TEX9,Q9HD45,Q9NR77,P62072,O43681,O43615,Q96P70,Q567V2 15 +metalloprotease 0.6169896746950296 2.758777145378686 0.0058018085548012 0.601223950754611 0.0509269862032556 27 Q7Z2K6,O75844,Q5JRX3,Q9UIQ6,O43847,P42892,P53582,P55786 8 +primary active transporter 0.6816020411677687 2.6827909862282393 0.0073010605024823 0.6858231712576339 0.0549317885424863 17 Q9BUN8,Q6P4A7,Q9NS69,Q8N4H5,O60888,O75381,P16615 7 +voltage-gated ion channel 0.9051629439765656 2.529512270262932 0.0114221180095279 0.8371752035516564 0.0721877858202167 3 P21796,P45880 2 +oxidoreductase 0.5027281410405522 2.454469059894601 0.0141092805666269 0.8940875545858721 0.0791193378471041 42 Q86Y39,Q15067,O95168,O15254,O14949,Q8N0U8,Q8N4Q0,O75306,P16435,O96000,O43169,O43676 12 +membrane trafficking regulatory protein 0.6430638794260338 2.4440875062395246 0.0145219037820634 0.9008661016437932 0.0791193378471041 17 Q8WTV0,O43760,Q14108,P24390 4 +oxygenase 0.8441813019760713 2.152773239356395 0.031336504273959 0.9934638275144086 0.1237791918821383 7 P30519,Q6UW02,P09601,Q16850 4 +secondary carrier transporter 0.774228170706591 2.072752728073675 0.0381952978550725 0.9978731857527314 0.1403455130488713 9 Q8TB61,Q02978,Q9UBX3 3 +transmembrane signal receptor 0.833708068626457 1.997382650467631 0.0457836310589978 0.9993915789292216 0.153910929943014 6 Q8WUJ1,O00264,O15173,Q99720 4 +mitochondrial carrier protein 0.8149159045144615 1.9164024904025487 0.0553138840775713 0.9998754252152848 0.1680691093126205 6 Q9NZJ7,Q70HW3 2 +acyltransferase 0.6234084260394521 1.895516958319267 0.0580239472195791 0.9999208778242854 0.1729770502017642 13 Q9BWD1,Q8NCC3,Q9HCL2,P23786 4 +kinase 0.5420941773932118 1.820682620780092 0.068655115485966 0.9999868336833772 0.196601104842472 18 Q13057,Q8NEB9,P35790,Q9BRR6,Q8TBX8,Q8WVC6,P14618 7 +aspartic protease 0.7436836323690956 1.8139761074184348 0.0696814042479647 0.9999889386301892 0.196601104842472 3 Q8TCT8,Q8TCT9 2 +ATP synthase 0.532360413551161 1.7907385919098429 0.0733352536664835 0.9999940601249288 0.1997753461949034 19 Q93050,Q9Y487 2 +SNARE protein 0.6772965009494513 1.6015848995117383 0.1092474322124168 0.9999999884755792 0.274650274971654 9 O15400,Q9P2W9,P51809,Q13190,Q9UEU0 5 +amino acid transporter 0.7674249994666644 1.5610083989514665 0.1185217691814495 0.999999997794884 0.2926006176667035 4 O14925,P30825 2 +esterase 0.7138226527107612 1.4710199484730868 0.1412857221233272 0.999999999964674 0.3235238274708073 6 Q9NUJ1,Q969T7,O14734 3 +oxidase 0.5262339948409 1.31862308370157 0.1872951525361805 0.999999999999994 0.3912567333009518 13 P36551,Q15800,P13073,P14406 4 +ATP-binding cassette (ABC) transporter 0.679584758413669 1.178572729679027 0.2385683558652986 1.0 0.4653555583545332 5 P08183,P28288,O75027 3 +reductase 0.4027409019710013 1.1619984290493994 0.2452361030509742 1.0 0.466757396488865 30 Q15392,Q9UBM7,Q14739,Q06136,Q9BY49,P30043,Q9H7Z7,Q9UDW1 8 +protein modifying enzyme 0.4128075288941937 1.0764211844914655 0.281738932192874 1.0 0.5058494464372058 24 P13674,P50897,O60725,Q6P2P2,Q92791,Q86X55,Q86YN1,Q9UMR5 8 +serine protease 0.4386313720191691 0.9882943928121692 0.3230084907369734 1.0 0.560827928971888 16 P42785,Q86TI2,P67812 3 +calmodulin-related 0.4549797898850548 0.9570767619453312 0.3385285117609617 1.0 0.5748137008956767 14 Q02818,Q14257,O43852,Q9BRK5 4 +phospholipase 0.5322108037705509 0.79376789289812 0.4273305673512921 1.0 0.6492137465529246 8 Q8NHP8,Q8IV08 2 +protein-binding activity modulator 0.5133650677407544 0.7421296653890744 0.45800877770715 1.0 0.6839310215938492 3 Q9UNZ2,O14737 2 +ion channel 0.5603015282221777 0.6781371680858186 0.4976847263477806 1.0 0.734898941709807 5 Q96S66,P51790 2 +homeodomain transcription factor 0.4855364335408276 0.6197230668252296 0.5354401265075885 1.0 0.7621580179117027 3 Q13330,Q99626 2 +membrane traffic protein 0.3058388771846447 0.5439834566407679 0.5864528570873881 1.0 0.7919619779470712 53 Q96PC5,Q99523,A6NIH7,P43307,Q13432,P51572,O60313,Q00765,Q9NX40 9 +transferase 0.3358332526978989 0.5095344211658783 0.6103776774797689 1.0 0.8104174205193571 27 P37268,P19623,Q8NCH0,Q7LGA3,P48651,Q9BXW7,Q9Y5P6 7 +protease 0.3084235936055507 0.4980877020895589 0.6184222281442588 1.0 0.8142559337232741 40 Q15005,O75976,Q9NQW7,P20618,P49721,P28066,O43242,P28072,Q99436,P60900,P48556,P28070,P28074,Q9BT78 14 +non-receptor serine/threonine protein kinase 0.3014032701761188 0.4498713345735086 0.6528032179722114 1.0 0.8412864387607181 42 Q99640,P48729,P11802,Q15120,P31751,P36507,Q13153,Q13555,Q13546 9 +nucleotidyltransferase 0.4126036480495951 0.3307379905318721 0.7408424034206846 1.0 0.8867659071247589 3 Q9NVV4 1 +transfer/carrier protein 0.3799719508936219 0.2708662065976717 0.786493936937763 1.0 0.9143709757942688 11 O15126,Q9Y5M8,O15127 3 +galactosidase 0.3448023426061428 0.2626236674558896 0.7928406562266761 1.0 0.9143709757942688 2 P16278 1 +transcription cofactor 0.3818344580575587 0.2325927337998978 0.8160776701745691 1.0 0.9260277309923262 10 Q13363,O00625 2 +RNA splicing factor 0.2598001198430418 0.2268621934033712 0.8205309008792763 1.0 0.9260277309923262 80 P52272,Q15637,Q9UHX1,Q9BQ04,Q16637,P52597,P55795,Q96PK6,Q92917,P31942,Q9BWF3,O75525,Q93062,Q13242,Q07955,Q52LJ0,Q07666,P31943,Q15287 19 +glucosidase 0.3515195898938119 0.1458146206648246 0.88406773364859 1.0 0.9700187633088696 3 Q13724,P10253 2 +cytoskeletal protein 0.3846621149054881 0.1015967314336514 0.9190767739637868 1.0 0.9845497232359258 5 P27105 1 +hydrolase 0.2829773548926345 0.0725576136073325 0.942158157212288 1.0 0.9858343631757714 21 O43865,P07099 2 +methyltransferase 0.3115457182402654 0.0537832306482495 0.957107870184247 1.0 0.9948884440073094 12 Q8N6R0,P04818,P21964 3 +translation initiation factor 0.2523985507987996 0.0092809676669493 0.9925949654965038 1.0 1.0 43 Q13144,Q13347,Q92905,P49770,O75153,Q01085,Q7L5N1,P60228,Q9NR50,P55010,P31483 11 diff --git a/panther_protein_class/selections.json b/panther_protein_class/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..8687624f68a315c0ade75a9ae72d1b72291cb825 --- /dev/null +++ b/panther_protein_class/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["ATP synthase", "ATP-binding cassette (ABC) transporter", "C2H2 zinc finger transcription factor", "DNA glycosylase", "DNA helicase", "DNA ligase", "DNA metabolism protein", "DNA methyltransferase", "DNA polymerase processivity factor", "DNA topoisomerase", "DNA-binding transcription factor", "DNA-directed DNA polymerase", "DNA-directed RNA polymerase", "G-protein", "G-protein coupled receptor", "G-protein modulator", "GTPase-activating protein", "Hsp90 family chaperone", "P53-like transcription factor", "RNA helicase", "RNA metabolism protein", "RNA methyltransferase", "RNA processing factor", "RNA splicing factor", "Rel homology transcription factor", "SNARE protein", "acetyltransferase", "actin and actin related protein", "actin binding motor protein", "actin or actin-binding cytoskeletal protein", "acyltransferase", "aldolase", "amino acid kinase", "amino acid transporter", "aminoacyl-tRNA synthetase", "amylase", "antimicrobial response protein", "apolipoprotein", "aspartic protease", "basic leucine zipper transcription factor", "cadherin", "calcium-binding protein", "calmodulin-related", "carbohydrate kinase", "cell adhesion molecule", "centromere DNA-binding protein", "chaperone", "chaperonin", "chromatin/chromatin-binding, or -regulatory protein", "cyclase", "cysteine protease", "cytokine", "cytoskeletal protein", "damaged DNA-binding protein", "deaminase", "decarboxylase", "defense/immunity protein", "dehydratase", "dehydrogenase", "endodeoxyribonuclease", "endoribonuclease", "epimerase/racemase", "esterase", "exodeoxyribonuclease", "exoribonuclease", "extracellular matrix glycoprotein", "extracellular matrix protein", "extracellular matrix structural protein", "galactosidase", "general transcription factor", "glucosidase", "glycosidase", "glycosyltransferase", "growth factor", "guanyl-nucleotide exchange factor", "heterotrimeric G-protein", "histone", "histone modifying enzyme", "homeodomain transcription factor", "hydratase", "hydrolase", "integrin", "intercellular signal molecule", "intermediate filament binding protein", "ion channel", "isomerase", "kinase", "kinase activator", "kinase inhibitor", "kinase modulator", "ligase", "lipase", "lyase", "mRNA capping factor", "mRNA polyadenylation factor", "major histocompatibility complex protein", "membrane traffic protein", "membrane trafficking regulatory protein", "metalloprotease", "methyltransferase", "microtubule binding motor protein", "microtubule or microtubule-binding cytoskeletal protein", "mitochondrial carrier protein", "mutase", "non-motor actin binding protein", "non-motor microtubule binding protein", "non-receptor serine/threonine protein kinase", "nucleic acid metabolism protein", "nucleotide kinase", "nucleotide phosphatase", "nucleotidyltransferase", "oxidase", "oxidoreductase", "oxygenase", "peptide hormone", "peroxidase", "phosphatase", "phosphatase activator", "phosphatase modulator", "phosphodiesterase", "phospholipase", "primary active transporter", "primase", "protease", "protease inhibitor", "protein modifying enzyme", "protein phosphatase", "protein-binding activity modulator", "pyrophosphatase", "reductase", "replication origin binding protein", "ribosomal protein", "scaffold/adaptor protein", "secondary carrier transporter", "serine protease", "small GTPase", "structural protein", "tight junction", "transaminase", "transcription cofactor", "transfer/carrier protein", "transferase", "transketolase", "translation elongation factor", "translation factor", "translation initiation factor", "translation release factor", "translational protein", "transmembrane signal receptor", "transporter", "tubulin", "tyrosine protein kinase receptor", "ubiquitin-protein ligase", "vesicle coat protein", "viral or transposable element protein", "voltage-gated ion channel", "winged helix/forkhead transcription factor", "zinc finger transcription factor"], "available_proteins": ["AAR2", "AARS", "AARS2", "AARSD1", "AASDHPPT", "AASS", "AATF", "ABCB1", "ABCB10", "ABCB7", "ABCD3", "ABCF1", "ABCF2", "ABHD10", "ABHD12", "ABHD6", "ACAA2", "ACAD9", "ACADM", "ACADVL", "ACAT1", "ACAT2", "ACBD5", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT8", "ACOT9", "ACOX1", "ACOX3", "ACP1", "ACP2", "ACP6", "ACSL1", "ACSL3", "ACSL4", "ACTR10", "ACTR1A", "ACTR2", "ACTR3", "ADA", "ADAR", "ADD1", "ADD3", "ADH5", "ADI1", "ADPGK", "ADPRHL2", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGK", "AGPAT1", "AHCTF1", "AHCY", "AHCYL1", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AK4", "AK6", "AKAP12", "AKAP8", "AKAP8L", "AKR1A1", "AKR1B1", "AKR7A2", "AKT2", "ALDH18A1", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALG1", "ALKBH5", "ALYREF", "ANAPC1", "ANAPC7", "ANKFY1", "ANKHD1", "ANKRD50", "ANLN", "ANP32A", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP1M1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "APEH", "APOL2", "APP", "APPL1", "APRT", "ARCN1", "ARF4", "ARF5", "ARFGAP1", "ARFIP1", "ARFIP2", "ARHGDIA", "ARHGEF1", "ARID3B", "ARIH1", "ARL1", "ARL6IP5", "ARPC1A", "ARPC3", "ARPC4", "ARPC5", "ASAH1", "ASCC3", "ASF1A", "ASNA1", "ASNS", "ASPH", "ATAD5", "ATE1", "ATG7", "ATL2", "ATP1A1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5L", "ATP5O", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1D", "ATP6V1H", "ATPAF1", "ATPIF1", "ATXN2L", "AUP1", "AURKA", "B3GALT6", "B4GAT1", "BAG2", "BAG6", "BAIAP2", "BAP18", "BCAP31", "BCAS2", "BCLAF1", "BDH2", "BLMH", "BLVRA", "BLVRB", "BOP1", "BPNT1", "BRIX1", "BSG", "BTF3", "BUB1", "BUB1B", "BUB3", "BUD31", "BZW1", "BZW2", "CACYBP", "CAD", "CALD1", "CALM3", "CALR", "CALU", "CAMK2G", "CAND1", "CANX", "CAP1", "CAPN1", "CAPRIN1", "CAPZA1", "CAPZB", "CARHSP1", "CARM1", "CARS", "CARS2", "CASK", "CASP3", "CASP6", "CASP7", "CASP8", "CAST", "CBR1", "CBX8", "CCAR1", "CCAR2", "CCDC94", "CCNB1", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2BP2", "CD3EAP", "CD47", "CDC16", "CDC23", "CDC27", "CDC37", "CDC40", "CDC42", "CDC45", "CDIPT", "CDK1", "CDK12", "CDK2", "CDK4", "CDK6", "CDKN2AIP", "CDS2", "CDX2", "CEBPZ", "CETN2", "CFL1", "CFL2", "CHAF1B", "CHEK2", "CHERP", "CHKA", "CHML", "CHMP1A", "CHMP2B", "CHMP5", "CHMP6", "CHMP7", "CHORDC1", "CHRAC1", "CHST14", "CKAP2", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLCC1", "CLCN3", "CLGN", "CLIC1", "CLIC4", "CLNS1A", "CLPB", "CLPP", "CLPX", "CLTA", "CLTC", "CLUH", "CMPK1", "CMSS1", "CNDP2", "CNN2", "CNN3", "CNOT1", "CNOT7", "CNP", "COA3", "COASY", "COIL", "COLEC12", "COLGALT1", "COMT", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS8", "COPZ1", "CORO1B", "CORO1C", "COTL1", "COX15", "COX2", "COX4I1", "COX5A", "COX5B", "COX7A2", "COX7C", "CPD", "CPOX", "CPSF1", "CPSF3", "CPSF6", "CPSF7", "CPT1A", "CPT2", "CPVL", "CRKL", "CRMP1", "CRNKL1", "CRTAP", "CRYZ", "CS", "CSE1L", "CSNK1A1", "CSNK2B", "CSTB", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTNNA1", "CTNND1", "CTPS1", "CTPS2", "CTR9", "CTSA", "CTSC", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4A", "CUL4B", "CUL5", "CUTA", "CYB5B", "CYB5D2", "CYB5R3", "CYFIP1", "CYP20A1", "CYP51A1", "DAD1", "DAGLB", "DAP3", "DARS", "DARS2", "DBN1", "DBNL", "DCAF13", "DCAKD", "DCP1A", "DCPS", "DCTD", "DCTN1", "DCTN2", "DCTN3", "DCTN4", "DCTN6", "DCTPP1", "DCXR", "DDAH1", "DDB1", "DDI2", "DDOST", "DDT", "DEK", "DENR", "DERL1", "DHCR24", "DHCR7", "DHFR", "DHRS7B", "DHX15", "DHX16", "DHX30", "DHX36", "DHX37", "DHX38", "DHX8", "DHX9", "DIDO1", "DIEXF", "DIS3", "DKC1", "DLAT", "DLD", "DLST", "DNAAF5", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC2", "DNAJC7", "DNAJC8", "DNAJC9", "DNM1L", "DNM2", "DNMT1", "DNPH1", "DOCK7", "DOHH", "DOLPP1", "DPF2", "DPH5", "DPP3", "DPP9", "DPYSL2", "DPYSL3", "DSG2", "DSP", "DST", "DSTN", "DTYMK", "DUSP9", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNLL1", "DYNLL2", "EARS2", "EBP", "ECE1", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "ECSIT", "EDC4", "EEA1", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF2", "EEFSEC", "EFL1", "EFTUD2", "EHD1", "EHD4", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2D", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF4B", "EIF4E", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAC2", "ELAVL1", "ELOB", "ELOC", "ELP1", "ELP3", "EMC2", "EMG1", "ENAH", "ENO1", "EPHX1", "EPHX2", "EPPK1", "EPRS", "EPS15", "EPS15L1", "ERAL1", "ERAP1", "ERCC2", "ERCC3", "ERH", "ERMP1", "ERO1A", "ERP29", "ESD", "ETF1", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXO1", "EXOC1", "EXOC4", "EXOC5", "EXOC7", "EXOSC3", "EXOSC4", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC8", "EZR", "FAHD1", "FAM3C", "FAM98A", "FAM98B", "FARSA", "FARSB", "FBL", "FDFT1", "FDPS", "FDX1", "FDXR", "FECH", "FEN1", "FH", "FKBP14", "FKBP1A", "FKBP3", "FKBP4", "FKBP5", "FKBP7", "FKBP8", "FLAD1", "FLII", "FMR1", "FN3KRP", "FNDC3A", "FNTB", "FOXC1", "FOXRED1", "FRYL", "FSCN1", "FTO", "FTSJ1", "FTSJ3", "FUBP1", "FUBP3", "FUCA1", "FUCA2", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GALK1", "GALNT2", "GALNT7", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GATAD2A", "GATAD2B", "GATB", "GBE1", "GBF1", "GCAT", "GCC2", "GCDH", "GCLM", "GCN1", "GDI1", "GDI2", "GDPD1", "GFPT1", "GGH", "GINS2", "GLA", "GLB1", "GLDC", "GLMN", "GLO1", "GLRX3", "GLRX5", "GLS", "GLUD1", "GLYR1", "GM2A", "GMDS", "GMFB", "GMPPA", "GMPPB", "GMPS", "GNA13", "GNAI1", "GNAI2", "GNAI3", "GNPDA1", "GNS", "GOLGA3", "GOLT1B", "GOT1", "GOT2", "GPAM", "GPATCH4", "GPD2", "GPI", "GPKOW", "GPR107", "GPR108", "GPR89B", "GPT2", "GPX8", "GRHPR", "GRPEL1", "GRSF1", "GSK3A", "GSK3B", "GSPT1", "GSR", "GSS", "GSTK1", "GSTM3", "GSTZ1", "GTF2B", "GTF2E1", "GTF2F1", "GTF2F2", "GTF2I", "GTF3C1", "GTF3C3", "GTPBP1", "GTPBP3", "GYG1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HADHB", "HAT1", "HBS1L", "HCCS", "HDGF", "HDGFL2", "HDHD2", "HDHD5", "HDLBP", "HEATR1", "HECTD1", "HEXA", "HEXB", "HIBADH", "HIBCH", "HINT2", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HM13", "HMBS", "HMGA1", "HMGCL", "HMOX1", "HMOX2", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPM", "HNRNPR", "HOOK3", "HP1BP3", "HPRT1", "HS2ST1", "HSD17B10", "HSDL1", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPE1", "HTATSF1", "HUS1", "HUWE1", "IARS", "IARS2", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDI1", "IGBP1", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IK", "ILF2", "ILF3", "ILK", "ILKAP", "ILVBL", "IMP3", "IMPDH1", "IMPDH2", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "ISOC1", "ISYNA1", "ITCH", "ITGB1", "ITPA", "IVD", "KARS", "KAT7", "KCTD12", "KDELR1", "KDM1A", "KDM1B", "KDM3B", "KDSR", "KHDRBS1", "KHDRBS3", "KHSRP", "KIAA0368", "KIF11", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF3A", "KIF4A", "KIF5B", "KIFC1", "KLC1", "KLC2", "KLC4", "KPNA1", "KPNA2", "KPNA3", "KPNA6", "KPNB1", "KYAT3", "L1RE1", "L2HGDH", "LAMP1", "LAMP2", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LBR", "LDHA", "LDHB", "LDLR", "LENG8", "LETM1", "LGALS3", "LGMN", "LIG1", "LIG3", "LIMA1", "LIPA", "LLGL1", "LMAN1", "LMAN2", "LNPEP", "LONP1", "LPCAT1", "LPP", "LRPAP1", "LRRC40", "LRRC47", "LRRC59", "LSM6", "LSM7", "LSM8", "LSS", "LYAR", "LYPLA1", "LZTFL1", "M6PR", "MACF1", "MAGED2", "MAGT1", "MAP1B", "MAP1S", "MAP2K1", "MAP2K2", "MAP2K3", "MAPK1", "MAPK14", "MAPRE1", "MAPRE2", "MARS", "MARS2", "MASTL", "MAT2A", "MAT2B", "MBNL1", "MBOAT7", "MCCC1", "MCCC2", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCTS1", "MDH1", "MDH2", "ME2", "MECP2", "MED1", "MED24", "METAP1", "METTL13", "MFAP1", "MFSD5", "MGEA5", "MGST2", "MGST3", "MIA2", "MIA3", "MICU1", "MICU2", "MID1", "MIF", "MINPP1", "MIPEP", "MMAB", "MMS19", "MOGS", "MON2", "MORF4L1", "MPHOSPH10", "MPI", "MPP1", "MPP2", "MPP6", "MPRIP", "MPST", "MPV17L2", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL14", "MRPL15", "MRPL17", "MRPL19", "MRPL20", "MRPL21", "MRPL37", "MRPL38", "MRPL39", "MRPL40", "MRPL43", "MRPL44", "MRPL45", "MRPL47", "MRPL48", "MRPL49", "MRPL50", "MRPL53", "MRPL58", "MRPL9", "MRPS15", "MRPS17", "MRPS2", "MRPS22", "MRPS23", "MRPS25", "MRPS27", "MRPS30", "MRPS31", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRPS9", "MSH2", "MSH3", "MSH6", "MSMO1", "MSN", "MTA1", "MTA2", "MTAP", "MTCH1", "MTCH2", "MTOR", "MTPAP", "MUT", "MYBBP1A", "MYCBP", "MYDGF", "MYEF2", "MYG1", "MYL6", "MYO1B", "MYO1D", "MYO6", "NAA10", "NAA15", "NAA25", "NAA35", "NAA50", "NAE1", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NAPG", "NARS", "NASP", "NAT10", "NAXE", "NBN", "NCAPD2", "NCBP1", "NCBP2", "NCDN", "NCOA5", "NDRG3", "NDUFA10", "NDUFA11", "NDUFA13", "NDUFA2", "NDUFA4", "NDUFA5", "NDUFA7", "NDUFA8", "NDUFA9", "NDUFB10", "NDUFB11", "NDUFB3", "NDUFB4", "NDUFB5", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS7", "NDUFS8", "NDUFV1", "NDUFV2", "NECAP2", "NENF", "NFKB1", "NFS1", "NHP2", "NIP7", "NISCH", "NKRF", "NKTR", "NLN", "NME1", "NME2", "NMT1", "NNT", "NOC4L", "NOL6", "NOL9", "NONO", "NOP10", "NOP14", "NOP56", "NOP58", "NOP9", "NPEPPS", "NPM1", "NRBP1", "NRDC", "NSDHL", "NSF", "NSFL1C", "NSUN2", "NT5C2", "NT5C3B", "NT5DC1", "NT5DC2", "NTMT1", "NTPCR", "NUCB1", "NUCB2", "NUDC", "NUDCD2", "NUDT1", "NUDT21", "NUDT5", "NUDT9", "NUMA1", "NUP107", "NUP153", "NUP155", "NUP160", "NUP210", "NUP214", "NUP37", "NUP50", "NUP54", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NXF1", "NXN", "OAT", "OCIAD1", "OCLN", "OGDH", "OGT", "OLA1", "OPA1", "OSGEP", "OTUB1", "OXA1L", "P3H1", "P3H4", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPN1", "PACSIN2", "PACSIN3", "PAFAH1B3", "PAK1", "PAK1IP1", "PAK2", "PALLD", "PANK4", "PARN", "PARP1", "PARP2", "PASK", "PBK", "PBRM1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCK2", "PCMT1", "PCNA", "PCYOX1", "PDCD11", "PDCD4", "PDCD5", "PDCD6", "PDCD6IP", "PDCL3", "PDE12", "PDE6D", "PDHA1", "PDHB", "PDIA3", "PDIA4", "PDIA6", "PDK3", "PDLIM1", "PDLIM5", "PDLIM7", "PDS5A", "PDS5B", "PDXK", "PEBP1", "PECR", "PELO", "PEPD", "PES1", "PEX14", "PEX19", "PEX5", "PFDN2", "PFDN5", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGP", "PGRMC1", "PGRMC2", "PHF6", "PHGDH", "PI4K2A", "PI4KB", "PICALM", "PIK3C3", "PIN1", "PINX1", "PIP4K2C", "PIR", "PISD", "PITHD1", "PITPNA", "PITPNB", "PITRM1", "PKM", "PKMYT1", "PKN1", "PKN2", "PLA2G15", "PLAA", "PLBD2", "PLCG1", "PLD3", "PLD6", "PLEC", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLS3", "PM20D2", "PMPCA", "PMPCB", "PNP", "PNPLA8", "PNPT1", "POFUT1", "POGZ", "POLA1", "POLA2", "POLD1", "POLDIP3", "POLE", "POLE3", "POLE4", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2A", "POLR2B", "POLR2C", "POLR2E", "POLR2G", "POLR2L", "POLR3A", "POLRMT", "POR", "PPA1", "PPA2", "PPAN", "PPAT", "PPIB", "PPID", "PPIE", "PPIF", "PPIH", "PPIL1", "PPIL4", "PPM1G", "PPME1", "PPOX", "PPP1CA", "PPP1CB", "PPP1R10", "PPP1R12A", "PPP1R7", "PPP1R8", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP4R3A", "PPP5C", "PPP6C", "PPT1", "PPT2", "PQBP1", "PRAF2", "PRC1", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PREP", "PREPL", "PRIM1", "PRIM2", "PRKACA", "PRKAG1", "PRKAR1A", "PRKAR2A", "PRKCSH", "PRKDC", "PRMT1", "PRMT3", "PRMT5", "PRMT9", "PRPF19", "PRPF3", "PRPF31", "PRPF39", "PRPF4", "PRPF4B", "PRPF6", "PRPF8", "PRPS2", "PRPSAP1", "PRPSAP2", "PRRC2A", "PRRC2C", "PSAP", "PSAT1", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD7", "PSMD8", "PSMF1", "PSMG1", "PSMG3", "PSPC1", "PTCD1", "PTDSS1", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK7", "PTPA", "PTPN1", "PUF60", "PUM1", "PURA", "PWP1", "PXMP2", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QDPR", "QKI", "QRSL1", "RAB3GAP1", "RAB3GAP2", "RABGAP1", "RAC1", "RAD23A", "RAD23B", "RAD9A", "RAE1", "RALA", "RALB", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP9", "RANGAP1", "RAPGEF2", "RARS", "RARS2", "RAVER1", "RBBP6", "RBM12", "RBM12B", "RBM14", "RBM17", "RBM19", "RBM22", "RBM26", "RBM27", "RBM34", "RBM4", "RBM4B", "RBPMS", "RCL1", "RCN1", "RCN2", "RDH11", "RDH13", "RDH14", "RDX", "RECQL", "REEP5", "REPS1", "REXO4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RFX1", "RHEB", "RHOA", "RHOG", "RHOT1", "RIDA", "RIF1", "RIPK1", "RNASEH2A", "RNF14", "RNPS1", "ROCK2", "RP2", "RPA1", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPN1", "RPN2", "RPP30", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RRBP1", "RRM1", "RRM2", "RRS1", "RSF1", "RSL1D1", "RSU1", "RTN4IP1", "S100A10", "S100A11", "S100A13", "SACM1L", "SAE1", "SAMHD1", "SAP130", "SAP18", "SARS", "SARS2", "SART1", "SART3", "SBDS", "SC5D", "SCAF1", "SCAF4", "SCAMP1", "SCAMP2", "SCAMP3", "SCARB1", "SCARB2", "SCFD1", "SCML2", "SCO1", "SCO2", "SCP2", "SCPEP1", "SCRIB", "SDF4", "SDHA", "SDHB", "SEC11A", "SEC23A", "SEC23B", "SEC23IP", "SEC24A", "SEC24B", "SEC24C", "SEC31A", "SEC61A1", "SEC61B", "SEC63", "SEH1L", "SENP3", "SEPHS1", "SEPT11", "SEPT2", "SEPT7", "SEPT9", "SERBP1", "SERPINB6", "SERPINH1", "SET", "SETD2", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFSWAP", "SFXN1", "SFXN4", "SHMT1", "SHMT2", "SHOC2", "SIGMAR1", "SKIV2L", "SKIV2L2", "SKP1", "SLC16A1", "SLC19A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A20", "SLC25A22", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A33", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A4", "SLC29A1", "SLC33A1", "SLC35B2", "SLC7A1", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCC1", "SMARCC2", "SMARCE1", "SMC6", "SMN1*", "SMNDC1", "SMPD4", "SMYD3", "SNAP23", "SNAP29", "SNRNP200", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNU13", "SNW1", "SNX1", "SNX17", "SNX2", "SNX27", "SNX5", "SNX6", "SNX9", "SOAT1", "SOD2", "SON", "SORD", "SORT1", "SPAG9", "SPCS2", "SPEN", "SPOUT1", "SPPL2A", "SPR", "SPTLC1", "SPTLC2", "SQLE", "SREK1", "SRI", "SRM", "SRP14", "SRP54", "SRP68", "SRP9", "SRPK1", "SRPRA", "SRPRB", "SRRM1", "SRSF1", "SRSF10", "SRSF11", "SRSF3", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSR1", "STAG1", "STAG2", "STAM", "STAMBP", "STAT1", "STAT3", "STK4", "STOM", "STOML2", "STRAP", "STRBP", "STT3A", "STUB1", "STX12", "STX18", "STX5", "STX7", "STXBP3", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGP2", "SUN1", "SUPT16H", "SUPT6H", "SUPV3L1", "SURF4", "SURF6", "SUZ12", "SYNCRIP", "SYNGR2", "SYNJ2BP", "TAF15", "TAGLN2", "TALDO1", "TARS", "TARS2", "TBC1D10B", "TBC1D13", "TBC1D15", "TBC1D4", "TBC1D9B", "TBCA", "TBCC", "TBCD", "TBCE", "TBL3", "TCEA1", "TCERG1", "TCOF1", "TCP1", "TDRKH", "TECR", "TERF2IP", "TFCP2", "TFG", "TFRC", "THOC1", "THOC2", "THOC3", "THOP1", "THRAP3", "THUMPD3", "TIA1", "TIAL1", "TIGAR", "TIMM10", "TIMM17A", "TIMM17B", "TIMM23", "TIMM44", "TJP1", "TK1", "TKFC", "TKT", "TM9SF3", "TMED10", "TMED2", "TMED5", "TMED7", "TMED9", "TMOD1", "TMOD3", "TMPO", "TMX2", "TMX3", "TNPO1", "TNPO2", "TNPO3", "TOE1", "TOMM20", "TOMM22", "TOMM40", "TOMM5", "TOMM70", "TOP1", "TOP2A", "TOP2B", "TP53", "TP53BP1", "TPI1", "TPM1", "TPM3", "TPM4", "TPP1", "TPP2", "TPR", "TPT1", "TPX2", "TRAP1", "TRIM21", "TRIM24", "TRIM26", "TRIM27", "TRIM33", "TRIM35", "TRIP12", "TRIP13", "TRIR", "TRMT10C", "TRMT1L", "TROVE2", "TSFM", "TSG101", "TTYH3", "TUBB", "TUBB2A", "TUBB2B", "TUBB4A", "TUBB4B", "TUBB6", "TUBGCP2", "TUBGCP3", "TUFM", "TWF1", "TWF2", "TXLNA", "TXLNG", "TXNDC12", "TXNDC17", "TXNDC5", "TXNL1", "TXNRD1", "TYMS", "U2AF1", "U2SURP", "UBA1", "UBA2", "UBA3", "UBA6", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2S", "UBE3A", "UBE4B", "UBR4", "UBR5", "UBTF", "UCHL5", "UFL1", "UGDH", "UGGT1", "UHRF1", "UMPS", "UNC119", "UNC119B", "UNG", "UQCC1", "UQCR10", "UQCRB", "UQCRC1", "UQCRC2", "UQCRQ", "UROD", "USMG5", "USO1", "USP10", "USP11", "USP14", "USP15", "USP39", "USP47", "USP48", "USP5", "USP7", "USP9X", "UTP11", "UTP14A", "UTP15", "UTP3", "UTP6", "VAMP7", "VAPA", "VAPB", "VARS1", "VARS2", "VBP1", "VDAC1", "VDAC2", "VDAC3", "VKORC1L1", "VMP1", "VPS18", "VPS26A", "VPS29", "VPS33A", "VPS33B", "VPS35", "VPS4B", "VPS52", "VRK1", "VTA1", "VTI1B", "WARS", "WDHD1", "WDR1", "WDR82", "WIZ", "WNK1", "XAB2", "XPNPEP1", "XPNPEP3", "XPO1", "XPO5", "XPO7", "XPOT", "XRCC1", "XRCC5", "XRCC6", "XRN2", "YARS", "YARS2", "YEATS4", "YLPM1", "YME1L1", "YTHDC2", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2", "ZC3H11A", "ZC3H15", "ZC3H7A", "ZCCHC3", "ZCCHC8", "ZFR", "ZMPSTE24", "ZMYM2", "ZNF207", "ZNF24", "ZNF281", "ZNF326", "ZNF622", "ZW10", "ZYX"], "leading_proteins": ["ABCB1", "ABCB7", "ABCD3", "ABHD10", "ACAT2", "ACOT8", "ACOX1", "ACOX3", "ADPGK", "AHCYL1", "AKT2", "ASNA1", "ATP2A2", "ATP6V0A1", "ATP6V0A2", "BCAP31", "BLVRB", "CALU", "CAMK2G", "CARM1", "CDK4", "CDX2", "CHKA", "CHST14", "CLCC1", "CLCN3", "CLUH", "COASY", "COMT", "COPS4", "COPS5", "COPS6", "COX4I1", "COX7A2", "CPD", "CPOX", "CPT2", "CSNK1A1", "CTBP1", "CUTA", "CYB5B", "CYB5D2", "CYP20A1", "CYP51A1", "DCAKD", "DERL1", "DHCR24", "DHCR7", "DOLPP1", "DPP9", "ECE1", "EIF2B2", "EIF2B3", "EIF2B5", "EIF3E", "EIF3I", "EIF5", "EPHX1", "ERMP1", "FAM98B", "FDFT1", "GAA", "GLB1", "GMPPB", "GPAM", "GPKOW", "GPR107", "HDHD5", "HM13", "HMOX1", "HMOX2", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPM", "HS2ST1", "ICMT", "IPO4", "IPO9", "KDELR1", "KDSR", "KHDRBS1", "KHDRBS3", "LBR", "LNPEP", "MAP2K2", "METAP1", "METTL13", "MIA2", "MOGS", "MPV17L2", "MSMO1", "MTA1", "MTCH1", 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/dev/null +++ b/pharos_dto/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2734, + "annotations_size": 1793, + "title": "Average number of proteins per term", + "value": 3.1204684885666483 +} \ No newline at end of file diff --git a/pharos_dto/paths.json b/pharos_dto/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..e657557ff8f9c0f6302c176c99ccb792e710b1e3 --- /dev/null +++ b/pharos_dto/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/pharos_dto/fragment/C166/C166_val_log2fc"} \ No newline at end of file diff --git a/pharos_dto/result.tsv b/pharos_dto/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..1d2b3cf13ad835c42c32310698d32e8fad12f1c6 --- /dev/null +++ b/pharos_dto/result.tsv @@ -0,0 +1,63 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +SLC35 family of nucleotide sugar transporters 0.95168374816984 3.2109449859645975 0.0013229925986708 0.906864165662256 0.0036494241991028 2 Q8TB61 1 +Transporter 0.4253419872156865 3.2006465031321216 0.0013711964215685 0.9145857480401668 0.0037480350638185 160 Q9HC07,Q8IXU6,P24390,Q9BQE5,O75027,P41440,Q9H2D1,P35606,Q9BSK2,Q9Y487,Q02978,P16615,Q00765,Q93050,P11166,P28288,Q70HW3,Q8TEX9,Q9HD45,Q13190,Q15070,O95202,O15400,O95487,P30825,P12236,Q9UBX3,Q8TB61,P50542,O43760,P08183,Q8N1F7,Q8NFH4,Q99523,Q9P2W9,Q9NZJ7,O96008,O43772,P51809,P51572,Q9H267,Q9UEU0 42 +SLC superfamily of solute carriers 0.6007332980217732 3.1246648887582924 0.0017800772444545 0.959013912210942 0.0044953218300097 36 Q9HC07,Q9Y619,Q8IXU6,P41440,Q9H2D1,Q9BSK2,Q02978,P11166,Q70HW3,Q9H9B4,O95202,Q7L0J3,P12236,P30825,Q9Y6C9,Q9UBX3,Q8TB61,P08195,P53985,Q9NZJ7,O43772 21 +SLC25 family of mitochondrial transporters 0.6974447357963988 2.8776718101364187 0.0040062168704588 0.9992516007875742 0.0083524963357357 19 Q70HW3,Q9NZJ7,O43772,Q9UBX3,Q9H2D1,Q02978 6 +Metalloprotease 0.5335705023698468 2.6438344373139233 0.0081972740851357 0.9999996104541512 0.0147878922812684 39 P53582,O75844,Q5JRX3,Q9UIQ6,Q7L5N1,O43847,P42892,Q7Z2K6,P55786 9 +SLC3 and SLC7 families of heteromeric amino acid transporters (HATs) 0.8268667642752645 2.6396639970214424 0.0082988260271834 0.9999996757922152 0.0149245687730591 2 P30825 1 +Receptor 0.6426336056974052 2.6368533134809615 0.0083679007756183 0.999999713856673 0.0150036460906836 21 Q9BUN8,Q8WTV0,A6NIH7,Q14108,Q13432,Q9NR77,O75381,Q567V2 8 +Miscellaneous SLC25 mitochondrial transporters 0.7840409956076235 2.4346219648014946 0.0149073549957057 0.9999999999979844 0.0240800788354057 2 Q9NZJ7 1 +Mitochondrial di- and tri-carboxylic acid transporter subfamily 0.8431093421781393 2.2607328519897663 0.0237758048598599 1.0 0.035377608393136 3 Q9UBX3 1 +Reductase 0.6012960262588954 2.177683494848649 0.0294296085469381 1.0 0.0419787495025139 17 Q15392,Q9UBM7,O95168,Q14739,P30043,Q9H7Z7,Q9UDW1 7 +PAKA subfamily 0.7119326500732116 2.0787473694786316 0.0376405766140859 1.0 0.0512060348020152 2 Q13153 1 +Signaling 0.5832003904398403 2.0597439696308864 0.0394230235598949 1.0 0.0531469783781139 17 Q96PC5,O00264,O15173,Q8WUJ1 4 +Non-protein kinase 0.5767113040713902 1.908222286155244 0.05636249235981 1.0 0.0710577707109952 16 Q8NEB9,P35790,P55263,P14618 4 +GSK subfamily 0.6625183016105468 1.8275024378965607 0.0676242599907277 1.0 0.0825393452439583 2 P49840 1 +GSK family 0.6625183016105468 1.8275024378965607 0.0676242599907277 1.0 0.0825393452439583 2 P49840 1 +Oxidoreductase 0.3555526654334759 1.8191973018146872 0.0688813343483365 1.0 0.0839023318522876 111 P36551,Q16850,Q9H845,O95168,P14406,P21912,Q8N0U8,Q8TED1,O75306,Q9BY49,Q9Y6M9,O43169,Q15392,Q15067,Q8N4Q0,P00367,P30043,Q14534,Q9UDW1,O15254,P43304,Q15800,Q9UBM7,Q14739,Q13423,P31350,Q9H7Z7 27 +SNARE protein 0.7446825093987322 1.815118404949268 0.0695057153526432 1.0 0.0845479970334392 8 O15400,Q9P2W9,P51809,Q13190,Q9UEU0 5 +MAPK family 0.650805270863837 1.767149974070075 0.077203115090187 1.0 0.0924066657921932 2 P28482 1 +Cell adhesion 0.6489751098096654 1.757694484826251 0.078799506767857 1.0 0.0939411673103508 2 Q9UNF1 1 +Mitochondrial nucleotide transporter subfamily 0.7193000212657952 1.69541425069687 0.0899968644164519 1.0 0.104307936586101 8 Q9H2D1,Q9BSK2,Q70HW3 3 +ABCB subfamily 0.7132298423001486 1.673544397080453 0.0942201741154427 1.0 0.1081633697793079 3 P08183 1 +Protease 0.3402997222891984 1.5869701565915455 0.112519403874242 1.0 0.1248436207589827 109 Q7L5N1,P67812,P61978,Q7Z2K6,Q92945,P55786,Q8TCT9,Q9UIQ6,P42892,Q10713,P53582,Q86TI2,Q8NHP8,Q96AE4,P53634,O43847,P42785,O75844,Q5BJF2,Q5JRX3,Q96I24 21 +V-type ATPase 0.6871536399739988 1.5421692161281246 0.1230324785983159 1.0 0.1342886828975268 8 Q9Y487 1 +F-type and V-type ATPases 0.5459476616008516 1.5298100631453415 0.126063749989514 1.0 0.1369063014725613 14 Q9Y487 1 +Oxidase 0.4950995121738355 1.4943396103712516 0.1350868770405704 1.0 0.1450363895411633 18 P36551,Q15800,Q9H845,Q15067,O15254,P14406,O43169 7 +Aspartic protease 0.7445984159231759 1.464588757168369 0.1430331512228178 1.0 0.1533842345349954 4 Q5BJF2,Q8TCT9 2 +Calcium-binding protein 0.484410491044706 1.4188842503022312 0.1559327647113735 1.0 0.1669178788820852 18 O43852,P43307,Q14257,Q9BRK5,Q02818 5 +ATP-binding cassette transporter family 0.7313018160454245 1.4082237613508757 0.1590648223953581 1.0 0.1699661660040984 4 P08183,O75027 2 +mRNA splicing factor 0.3671119000252328 1.3654398964794148 0.1721148315801954 1.0 0.1834731825346554 63 Q01844,Q15637,Q9BQ04,P23246,P35637,P62995,Q96PK6,P38159,Q92804,Q9BWF3,O75525,Q93062,Q13242,Q07955,Q07666,Q15287,P98179,Q8IY67,Q13595,Q15233 20 +BUB family 0.5647877013177229 1.3170303465264306 0.1878284526913822 1.0 0.1999859950567983 2 O43683 1 +Oxygenase 0.7110940421436913 1.3131996755168724 0.1891156733083248 1.0 0.2009984601314916 5 Q16850 1 +Mitochondrial amino acid transporter subfamily 0.6658282462972233 1.1198187223428866 0.2627910192790359 1.0 0.2778209301694053 5 Q9UJS0,Q9Y619,O43772 3 +CAMKL family 0.5234260614934181 1.0989836863907263 0.2717751816932636 1.0 0.2868919972040309 2 Q96RG2 1 +Translation initiation factor 0.4359763028678876 1.0989723437663377 0.2717801292803856 1.0 0.2868919972040309 19 O75153 1 +Histone deacetylase 0.5172035139092229 1.066314900768561 0.2862813158834769 1.0 0.3017650790000436 2 Q96EB6 1 +CAMK group 0.6434976693832306 1.024674348749372 0.3055168703614099 1.0 0.3212854830252247 5 O14936 1 +Intracellular calcium-sensing protein 0.4433339166252581 1.0202620937048603 0.3076041757768388 1.0 0.323101515622655 16 Q02818,Q14257,O43852,Q9BRK5 4 +Calmodulin 0.4433339166252581 1.0202620937048603 0.3076041757768388 1.0 0.323101515622655 16 Q02818,Q14257,O43852,Q9BRK5 4 +Extracellular structure 0.5440064482735769 0.9312478617069893 0.3517253651710275 1.0 0.368151535173177 9 P55081,Q32P28,Q92791 3 +mRNA processing factor 0.3106057761211012 0.8994312295002064 0.368423011042251 1.0 0.3854040016328799 76 Q01844,Q15637,Q9BQ04,P23246,P84103,P35637,P62995,Q96PK6,O95453,P38159,Q92804,Q9BWF3,O75525,Q93062,Q13242,Q07955,Q07666,Q15287,P98179,Q8IY67,Q13595,Q15233 22 +Phospholipase 0.6004588263315422 0.854278940527793 0.3929504529140624 1.0 0.4105828450320011 4 Q8NCC3 1 +Phosphatase modulator 0.5479497816954144 0.7953343082248006 0.4264190615666914 1.0 0.4445170798773707 7 Q15257,Q01105,Q99733 3 +Chromodomain 0.5228853899670451 0.7849843875127468 0.4324627224339687 1.0 0.4502936476911184 3 Q13185,P45973 2 +Kinase 0.2974644471774252 0.7620424671950471 0.4460346586306165 1.0 0.463886393807828 86 Q8NEB9,P35790,Q9BRR6,Q99640,Q8TBX8,P48729,P55263,Q15120,P14618,P36507,O14936,P31751,Q13555,Q13546 14 +Nucleotide phosphatase 0.5128873526131372 0.7027542136662737 0.4822089355150245 1.0 0.5002572250727684 8 O43681,Q8IWA4 2 +Cytokine 0.4271595900439308 0.6099606588350951 0.5418878686214161 1.0 0.5600028521257632 2 P43490 1 +Esterase 0.4609508534517407 0.5936897009424108 0.5527196727400656 1.0 0.5707713519748502 10 Q969T7,Q9UMR5,P50897,O14734 4 +Other small molecule kinase 0.5204894656927792 0.5218536188395362 0.6017722536999814 1.0 0.6201020982092338 5 P14618 1 +Acetyltransferase 0.3552448715904226 0.5156135609403248 0.6061243370170373 1.0 0.6238696534279838 19 Q96N66,P23786 2 +Phosphatase inhibitor 0.4879928069468234 0.4800997215579881 0.6311564862142853 1.0 0.6492619505348328 6 Q01105,Q99733 2 +Acyltransferase 0.4617778090973991 0.4719806561472138 0.6369405958680803 1.0 0.6544610248661707 8 P35610,P14324,P49356,Q9Y679 4 +P-type ATPases 0.4875636379558118 0.4145136630335201 0.6784979629452361 1.0 0.6943604707470145 4 P16615 1 +Translation factor 0.3193880894099223 0.3524705672335936 0.7244853879154607 1.0 0.7376503694108013 25 O75153 1 +Protein arginine methyltransferase 0.4655192804568294 0.3396217373431863 0.7341414061342 1.0 0.7466338861024507 4 Q86X55 1 +Membrane trafficking regulatory protein 0.3288700788772379 0.3368146621965819 0.7362566194150668 1.0 0.7483606114576048 19 O43760,P24390 2 +Transaminase 0.4112871185256371 0.2076302660169308 0.8355176704636404 1.0 0.8476716754362917 6 Q6YP21 1 +STE group 0.388789229853332 0.1624847888321779 0.8709241058567914 1.0 0.8817430388488012 7 P36507 1 +Protein kinase 0.2627789507667427 0.0975935862404429 0.9222550176328292 1.0 0.9316074628820636 52 Q99640,P48729,P11802,Q15120,P31751,P36507,O14936,Q13153,Q13555,Q13546 10 +Glycosyltransferase 0.3351392726603311 0.0921761805702761 0.9265580626137492 1.0 0.9349007350964842 11 Q9BT22,Q86SF2,Q10471,P46976,P46977 5 +Eraser 0.3704653719311035 0.0724441259380355 0.9422484696012868 1.0 0.9485971398063489 5 Q92769,Q96EB6,Q7LBC6,O60341 4 +STE20 family 0.3512248517947823 0.0542853645794195 0.9567078097331274 1.0 0.9614543365395768 4 Q13153 1 +Ion channel 0.3474909851309515 0.0537121235520071 0.9571645235488816 1.0 0.9614543365395768 7 Q96S66,P51790 2 diff --git a/pharos_dto/selections.json b/pharos_dto/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..5b1ee3a47d0612476c60f8f04e94988bcd969bd0 --- /dev/null +++ b/pharos_dto/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase", "1,4-alpha-glucan-branching enzyme", "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1", "10 kDa heat shock protein, mitochondrial", "116 kDa U5 small nuclear ribonucleoprotein component", "14-3-3 protein beta/alpha", "14-3-3 protein epsilon", "14-3-3 protein eta", "14-3-3 protein gamma", "14-3-3 protein theta", "14-3-3 protein zeta/delta", "2',3'-cyclic-nucleotide 3'-phosphodiesterase", "2',5'-phosphodiesterase 12", "2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial", "26S proteasome non-ATPase regulatory subunit 1", "26S proteasome non-ATPase regulatory subunit 12", "26S proteasome non-ATPase regulatory subunit 13", "26S proteasome non-ATPase regulatory subunit 14", "26S proteasome non-ATPase regulatory subunit 2", "26S proteasome non-ATPase regulatory subunit 3", "26S proteasome non-ATPase regulatory subunit 4", "26S proteasome non-ATPase regulatory subunit 7", "26S proteasome non-ATPase regulatory subunit 8", "26S proteasome regulatory subunit 10B", "26S proteasome regulatory subunit 4", "26S proteasome regulatory subunit 6A", "26S proteasome regulatory subunit 6B", "26S proteasome regulatory subunit 7", "26S proteasome regulatory subunit 8", "28S ribosomal protein S2, mitochondrial", "28S ribosomal protein S27, mitochondrial", "28S ribosomal protein S29, mitochondrial", "28S ribosomal protein S35, mitochondrial", "28S ribosomal protein S5, mitochondrial", "28S ribosomal protein S7, mitochondrial", "3'(2'),5'-bisphosphate nucleotidase 1", "3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase", "3-hydroxyacyl-CoA dehydrogenase type-2", "3-hydroxyisobutyrate dehydrogenase, mitochondrial", "3-hydroxyisobutyryl-CoA hydrolase, mitochondrial", "3-ketoacyl-CoA thiolase, mitochondrial", "3-mercaptopyruvate sulfurtransferase", "39S ribosomal protein L1, mitochondrial", "39S ribosomal protein L11, mitochondrial", "39S ribosomal protein L12, mitochondrial", "39S ribosomal protein L14, mitochondrial", "39S ribosomal protein L17, mitochondrial", "39S ribosomal protein L19, mitochondrial", "39S ribosomal protein L20, mitochondrial", "39S ribosomal protein L21, mitochondrial", "39S ribosomal protein L38, mitochondrial", "39S ribosomal protein L39, mitochondrial", "39S ribosomal protein L43, mitochondrial", "39S ribosomal protein L44, mitochondrial", "39S ribosomal protein L47, mitochondrial", "39S ribosomal protein L48, mitochondrial", "39S ribosomal protein L49, mitochondrial", "39S ribosomal protein L9, mitochondrial", "4-trimethylaminobutyraldehyde dehydrogenase", "40S ribosomal protein S10", "40S ribosomal protein S11", "40S ribosomal protein S12", "40S ribosomal protein S13", "40S ribosomal protein S14", "40S ribosomal protein S15", "40S ribosomal protein S15a", "40S ribosomal protein S17", "40S ribosomal protein S18", "40S ribosomal protein S19", "40S ribosomal protein S2", "40S ribosomal protein S20", "40S ribosomal protein S21", "40S ribosomal protein S23", "40S ribosomal protein S24", "40S ribosomal protein S28", "40S ribosomal protein S3", "40S ribosomal protein S3a", "40S ribosomal protein S4, X isoform", "40S ribosomal protein S5", "40S ribosomal protein S6", "40S ribosomal protein S7", "40S ribosomal protein S8", "40S ribosomal protein S9", "40S ribosomal protein SA", "45 kDa calcium-binding protein", "4F2 cell-surface antigen heavy chain", "5'-AMP-activated protein kinase subunit gamma-1", "5'-nucleotidase domain-containing protein 1", "5'-nucleotidase domain-containing protein 2", "55 kDa erythrocyte membrane protein", "6-phosphogluconate dehydrogenase, decarboxylating", "6-phosphogluconolactonase", "60 kDa SS-A/Ro ribonucleoprotein", "60S ribosomal protein L10", "60S ribosomal protein L10a", "60S ribosomal protein L11", "60S ribosomal protein L12", "60S ribosomal protein L13", "60S ribosomal protein L13a", "60S ribosomal protein L14", "60S ribosomal protein L15", "60S ribosomal protein L18", "60S ribosomal protein L19", "60S ribosomal protein L21", "60S ribosomal protein L22", "60S ribosomal protein L23", "60S ribosomal protein L23a", "60S ribosomal protein L24", "60S ribosomal protein L27", "60S ribosomal protein L27a", "60S ribosomal protein L28", "60S ribosomal protein L29", "60S ribosomal protein L3", "60S ribosomal protein L30", "60S ribosomal protein L31", "60S ribosomal protein L32", "60S ribosomal protein L35", "60S ribosomal protein L35a", "60S ribosomal protein L36", "60S ribosomal protein L36a", "60S ribosomal protein L37", "60S ribosomal protein L38", "60S ribosomal protein L5", "60S ribosomal protein L6", "60S ribosomal protein L7", "60S ribosomal protein L7-like 1", "60S ribosomal protein L7a", "60S ribosomal protein L8", "60S ribosomal protein L9", "7,8-dihydro-8-oxoguanine triphosphatase", "7-dehydrocholesterol reductase", "7-methylguanosine phosphate-specific 5'-nucleotidase", "ABCB subfamily", "ABCD subfamily of peroxisomal ABC transporters", "ADP-dependent glucokinase", "ADP-ribose pyrophosphatase, mitochondrial", "ADP-sugar pyrophosphatase", "ADP/ATP translocase 1", "ADP/ATP translocase 2", "ADP/ATP translocase 3", "AFG3-like protein 2", "AGC group", "AH receptor-interacting protein", "AK1 subfamily", "AK2 subfamily", "AKT family", "AP-1 complex subunit beta-1", "AP-1 complex subunit gamma-1", "AP-1 complex subunit mu-1", "AP-2 complex subunit alpha-2", "AP-2 complex subunit beta", "AP-2 complex subunit mu", "AP-2 complex subunit sigma", "AP-3 complex subunit beta-1", "AP-3 complex subunit delta-1", "AP-3 complex subunit mu-1", "AT-rich interactive domain-containing protein 3B", "ATP synthase F(0) complex subunit B1, mitochondrial", "ATP synthase mitochondrial F1 complex assembly factor 1", "ATP synthase subunit alpha, mitochondrial", "ATP synthase subunit beta, mitochondrial", "ATP synthase subunit d, mitochondrial", "ATP synthase subunit e, mitochondrial", "ATP synthase subunit gamma, mitochondrial", "ATP-binding cassette sub-family B member 10, mitochondrial", "ATP-binding cassette sub-family B member 7, mitochondrial", "ATP-binding cassette sub-family D member 3", "ATP-binding cassette sub-family F member 1", "ATP-binding cassette sub-family F member 2", "ATP-binding cassette transporter family", "ATP-citrate synthase", "ATP-dependent 6-phosphofructokinase, muscle type", "ATP-dependent 6-phosphofructokinase, platelet type", "ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial", "ATP-dependent DNA helicase Q1", "ATP-dependent PFK group I subfamily", "ATP-dependent RNA helicase A", "ATP-dependent RNA helicase DHX8", "ATP-dependent zinc metalloprotease YME1L1", "ATPase ASNA1", "ATPase family AAA domain-containing protein 3A", "ATPase family AAA domain-containing protein 3B", "ATPase inhibitor, mitochondrial", "AUR family", "Acetolactate synthase-like protein", "Acetyl-CoA acetyltransferase, cytosolic", "Acetyl-CoA acetyltransferase, mitochondrial", "Acetyl-coenzyme A transporter 1", "Acetyltransferase", "Acid ceramidase", "Acidic leucine-rich nuclear phosphoprotein 32 family member A", "Acidic leucine-rich nuclear phosphoprotein 32 family member B", "Acidic leucine-rich nuclear phosphoprotein 32 family member E", "Aconitate hydratase, mitochondrial", "Actin and actin related protein", "Actin binding motor protein", "Actin family cytoskeletal protein", "Actin-related protein 10", "Actin-related protein 2", "Actin-related protein 2/3 complex subunit 1A", "Actin-related protein 2/3 complex subunit 3", "Actin-related protein 2/3 complex subunit 4", "Actin-related protein 2/3 complex subunit 5", "Actin-related protein 3", "Acyl-CoA dehydrogenase family member 9, mitochondrial", "Acyl-CoA-binding domain-containing protein 5", "Acyl-coenzyme A thioesterase 8", "Acyl-coenzyme A thioesterase 9, mitochondrial", "Acylamino-acid-releasing enzyme", "Acylpyruvase FAHD1, mitochondrial", "Acyltransferase", "Adenosine 3'-phospho 5'-phosphosulfate transporter 1", "Adenosine deaminase", "Adenosine kinase", "Adenosylhomocysteinase", "Adenylate kinase 2, mitochondrial", "Adenylate kinase 4, mitochondrial", "Adenylate kinase family", "Adenylate kinase isoenzyme 1", "Adenylate kinase isoenzyme 6", "Adenylosuccinate lyase", "Adenylosuccinate synthetase isozyme 2", "Adenylyl cyclase-associated protein 1", "Afadin", "Aflatoxin B1 aldehyde reductase member 2", "Alanine aminotransferase 2", "Alanine--tRNA ligase, cytoplasmic", "Alanine--tRNA ligase, mitochondrial", "Alanine/serine/cysteine transporter subfamily", "Alanyl-tRNA editing protein Aarsd1", "Alcohol dehydrogenase [NADP(+)]", "Alcohol dehydrogenase class-3", "Aldehyde dehydrogenase X, mitochondrial", "Aldehyde dehydrogenase, mitochondrial", "Aldose reductase", "Alpha-adducin", "Alpha-aminoadipic semialdehyde dehydrogenase", "Alpha-centractin", "Alpha-enolase", "Alpha-globin transcription factor CP2", "Alpha-soluble NSF attachment protein", "Alpha-taxilin", "Amidophosphoribosyltransferase", "Aminoacyl tRNA synthase complex-interacting multifunctional protein 1", "Aminoacyl-tRNA synthetase", "Amylase", "Amyloid-beta A4 protein", "Anaphase-promoting complex subunit 1", "Ancient ubiquitous protein 1", "Anion channel tweety (tweety) family", "Antibacterial response protein", "Apolipoprotein", "Apolipoprotein L2", "Apoptosis-inducing factor 1, mitochondrial", "Arfaptin-1", "Arfaptin-2", "Asparagine synthetase [glutamine-hydrolyzing]", "Asparagine--tRNA ligase, cytoplasmic", "Aspartate--tRNA ligase, cytoplasmic", "Aspartate--tRNA ligase, mitochondrial", "Aspartic protease", "Ataxin-2-like protein", "Atlastin-2", "Atp-dependent 6-phosphofructokinase, liver type", "Atypical SLC22B subfamily", "Atypical group", "Aurora kinase a", "B-cell receptor-associated protein 31", "BTB/POZ domain-containing protein KCTD12", "BUB family", "BUB3-interacting and GLEBS motif-containing protein ZNF207", "Basic leucine zipper and W2 domain-containing protein 1", "Basic leucine zipper and W2 domain-containing protein 2", "Bcl-2 homologous antagonist/killer", "Bcl-2-associated transcription factor 1", "Beta-galactosidase", "Beta-hexosaminidase subunit alpha", "Beta-hexosaminidase subunit beta", "Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1", "Bifunctional coenzyme A synthase", "Bifunctional epoxide hydrolase 2", "Bifunctional glutamate/proline--tRNA ligase", "Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial", "Bifunctional purine biosynthesis protein PURH", "Biliverdin reductase A", "Biotin--protein ligase", "Bleomycin hydrolase", "Brain-specific angiogenesis inhibitor 1-associated protein 2", "Bromodomain", "Bromodomain-containing protein 4", "C-1-tetrahydrofolate synthase, cytoplasmic", "C-Jun-amino-terminal kinase-interacting protein 4", "C-terminal-binding protein 1", "C-terminal-binding protein 2", "C2H2 zinc finger transcription factor", "CAAX prenyl protease 1 homolog", "CAD protein", "CAMK group", "CAMK2 family", "CAMKL family", "CASK family", "CCAAT/enhancer-binding protein zeta", "CCK4 family", "CCR4-NOT transcription complex subunit 1", "CCR4-NOT transcription complex subunit 7", "CD2 antigen cytoplasmic tail-binding protein 2", "CDK family", "CDK1 subfamily", "CDK4 subfamily", "CDKN2A-interacting protein", "CK1 family", "CK1 group", "CK2 family", "CLIP-associating protein 1", "CMGC group", "COP9 signalosome complex subunit 3", "COP9 signalosome complex subunit 5", "COP9 signalosome complex subunit 6", "COP9 signalosome complex subunit 8", "CSK family", "CTP synthase 1", "CTP synthase 2", "Ca2+-ATPases", "Cadherin", "Calcium homeostasis endoplasmic reticulum protein", "Calcium uniporter protein, mitochondrial", "Calcium uptake protein 1, mitochondrial", "Calcium uptake protein 2, mitochondrial", "Calcium-binding mitochondrial carrier protein Aralar1", "Calcium-binding mitochondrial carrier protein Aralar2", "Calcium-binding mitochondrial carrier protein SCaMC-1", "Calcium-binding protein", "Calcium-regulated heat-stable protein 1", "Calcium/calmodulin-dependent protein kinase type ii subunit gamma", "Calcyclin-binding protein", "Calmegin", "Calmodulin", "Calmodulin-3", "Calnexin", "Calpain-1 catalytic subunit", "Calponin-2", "Calponin-3", "Calreticulin", "Calumenin", "Camp-dependent protein kinase catalytic subunit alpha", "Cancer-related nucleoside-triphosphatase", "Caprin-1", "Carbohydrate kinase", "Carbohydrate sulfotransferase 14", "Carnitine O-palmitoyltransferase 1, liver isoform", "Carnitine O-palmitoyltransferase 2, mitochondrial", "Cartilage-associated protein", "Casein kinase II subunit alpha'", "Casein kinase i isoform alpha", "Casein kinase ii subunit beta", "Caspase-3", "Caspase-6", "Caspase-7", "Caspase-8", "Catechol O-methyltransferase", "Catenin alpha-1", "Catenin delta-1", "Cation-dependent mannose-6-phosphate receptor", "Cation-independent mannose-6-phosphate receptor", "Cell adhesion", "Cell cycle and apoptosis regulator protein 2", "Cell cycle checkpoint control protein RAD9A", "Cell division control protein 42 homolog", "Cell division control protein 45 homolog", "Cell division cycle and apoptosis regulator protein 1", "Cell-cell junction", "Cellular structure", "Cellular tumor antigen p53", "Centrin-2", "Centromere/kinetochore protein zw10 homolog", "Chaperone", "Chaperonin", "Charged multivesicular body protein 5", "Charged multivesicular body protein 6", "Charged multivesicular body protein 7", "Chitobiosyldiphosphodolichol beta-mannosyltransferase", "Chloride channel CLIC-like protein 1", "Chloride channel family", "Chloride intracellular channel protein 1", "Chloride intracellular channel protein 4", "Choline kinase alpha", "Choline/ethanolamine kinase family", "Chromatin accessibility complex protein 1", "Chromatin assembly factor 1 subunit B", "Chromatin/chromatin-binding protein", "Chromobox protein homolog 1", "Chromobox protein homolog 3", "Chromobox protein homolog 5", "Chromodomain", "Chromosome-associated kinesin KIF4A", "Cilia- and flagella-associated protein 20", "Citrate synthase, mitochondrial", "ClC-3/CLCN3 subfamily", "Class I transporters", "Clathrin heavy chain 1", "Clathrin light chain A", "Cleavage and polyadenylation specificity factor subunit 1", "Cleavage and polyadenylation specificity factor subunit 3", "Cleavage and polyadenylation specificity factor subunit 5", "Cleavage and polyadenylation specificity factor subunit 6", "Cleavage and polyadenylation specificity factor subunit 7", "Cleavage stimulation factor subunit 2", "Cleavage stimulation factor subunit 3", "Cleft lip and palate transmembrane protein 1", "Cleft lip and palate transmembrane protein 1-like protein", "Clustered mitochondria protein homolog", "Coactosin-like protein", "Coatomer subunit alpha", "Coatomer subunit beta", "Coatomer subunit beta'", "Coatomer subunit delta", "Coatomer subunit epsilon", "Coatomer subunit gamma-1", "Coatomer subunit gamma-2", "Coatomer subunit zeta-1", "Cohesin subunit SA-1", "Cohesin subunit SA-2", "Coilin", "Cold-inducible RNA-binding protein", "Collectin-12", "Condensin complex subunit 1", "Core histone macro-H2A.1", "Core histone macro-H2A.2", "Coronin-1B", "Coronin-1C", "Creatine kinase B-type", "Creatine kinase U-type, mitochondrial", "Crooked neck-like protein 1", "Cullin-1", "Cullin-2", "Cullin-4A", "Cullin-4B", "Cullin-5", "Cullin-associated NEDD8-dissociated protein 1", "Cyclase", "Cyclin-dependent kinase 1", "Cyclin-dependent kinase 12", "Cyclin-dependent kinase 2", "Cyclin-dependent kinase 4", "Cyclin-dependent kinase 6", "Cystatin-B", "Cysteine and histidine-rich domain-containing protein 1", "Cysteine desulfurase, mitochondrial", "Cysteine protease", "Cysteine protease inhibitor", "Cysteine--tRNA ligase, cytoplasmic", "Cytochrome b-c1 complex subunit 1, mitochondrial", "Cytochrome b-c1 complex subunit 2, mitochondrial", "Cytochrome b-c1 complex subunit 7", "Cytochrome b-c1 complex subunit 9", "Cytochrome b5 type B", "Cytochrome c oxidase subunit 2", "Cytochrome c oxidase subunit 5A, mitochondrial", "Cytochrome c oxidase subunit 5B, mitochondrial", "Cytochrome c oxidase subunit 7A2, mitochondrial", "Cytochrome c oxidase subunit 7C, mitochondrial", "Cytochrome c oxidase subunit NDUFA4", "Cytochrome c-type heme lyase", "Cytokine", "Cytoplasmic FMR1-interacting protein 1", "Cytoplasmic aconitate hydratase", "Cytoplasmic dynein 1 heavy chain 1", "Cytoplasmic dynein 1 intermediate chain 2", "Cytoplasmic dynein 1 light intermediate chain 1", "Cytoskeleton-associated protein 5", "Cytosol aminopeptidase", "Cytosolic acyl coenzyme A thioester hydrolase", "Cytosolic non-specific dipeptidase", "Cytosolic purine 5'-nucleotidase", "D-3-phosphoglycerate dehydrogenase", "D-dopachrome decarboxylase", "DDB1- and CUL4-associated factor 13", "DMPK family", "DNA (cytosine-5)-methyltransferase 1", "DNA binding protein", "DNA damage-binding protein 1", "DNA helicase", "DNA ligase", "DNA ligase 1", "DNA ligase 3", "DNA methyltransferase", "DNA mismatch repair protein Msh2", "DNA mismatch repair protein Msh3", "DNA mismatch repair protein Msh6", "DNA polymerase alpha subunit B", "DNA polymerase epsilon subunit 4", "DNA polymerase processivity factor", "DNA primase small subunit", "DNA replication complex GINS protein PSF2", "DNA replication licensing factor MCM2", "DNA replication licensing factor MCM3", "DNA replication licensing factor MCM4", "DNA replication licensing factor MCM5", "DNA replication licensing factor MCM6", "DNA replication licensing factor MCM7", "DNA topoisomerase", "DNA topoisomerase 1", "DNA-directed DNA polymerase", "DNA-directed RNA polymerase", "DNA-directed RNA polymerase I subunit RPA1", "DNA-directed RNA polymerase I subunit RPA2", "DNA-directed RNA polymerase II subunit RPB1", "DNA-directed RNA polymerase II subunit RPB2", "DNA-directed RNA polymerase II subunit RPB3", "DNA-directed RNA polymerase II subunit RPB7", "DNA-directed RNA polymerase III subunit RPC1", "DNA-directed RNA polymerase, mitochondrial", "DNA-directed RNA polymerases I and III subunit RPAC1", "DNA-directed RNA polymerases I, II, and III subunit RPABC1", "DNA-directed RNA polymerases I, II, and III subunit RPABC5", "DNAPK subfamily", "DYRK family", "Damaged DNA-binding protein", "Deaminase", "Death-inducer obliterator 1", "Decarboxylase", "Dedicator of cytokinesis protein 7", "Dehydratase", "Dehydrogenase", "Delta(24)-sterol reductase", "Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial", "Delta-1-pyrroline-5-carboxylate synthase", "Density-regulated protein", "Deoxycytidylate deaminase", "Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial", "Derlin-1", "Desmoglein-2", "Desmoplakin", "Digestive organ expansion factor homolog", "Dihydrofolate reductase", "Dihydrolipoyl dehydrogenase, mitochondrial", "Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial", "Dihydropteridine reductase", "Dihydropyrimidinase-related protein 1", "Dihydropyrimidinase-related protein 2", "Dihydropyrimidinase-related protein 3", "Dipeptidyl peptidase 1", "Dipeptidyl peptidase 3", "Dipeptidyl peptidase 9", "Diphthine methyl ester synthase", "Dna-dependent protein kinase catalytic subunit", "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit", "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1", "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2", "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1", "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A", "Dolichyldiphosphatase 1", "Double-stranded RNA-specific adenosine deaminase", "Drebrin", "Drebrin-like protein", "Dual specificity mitogen-activated protein kinase kinase 1", "Dual specificity mitogen-activated protein kinase kinase 2", "Dual specificity mitogen-activated protein kinase kinase 3", "Dynactin subunit 1", "Dynactin subunit 2", "Dynactin subunit 6", "Dynamin-1-like protein", "Dynamin-2", "Dynamin-like 120 kDa protein, mitochondrial", "Dynein light chain 1, cytoplasmic", "Dynein light chain 2, cytoplasmic", "Dystonin", "E3 SUMO-protein ligase RanBP2", "E3 ubiquitin-protein ligase ARIH1", "E3 ubiquitin-protein ligase HUWE1", "E3 ubiquitin-protein ligase Itchy homolog", "E3 ubiquitin-protein ligase RBBP6", "E3 ubiquitin-protein ligase RNF14", "EH domain-containing protein 1", "EH domain-containing protein 4", "ER lumen protein-retaining receptor 1", "ER membrane protein complex subunit 2", "ERK subfamily", "ERO1-like protein alpha", "Early endosome antigen 1", "Electron transfer flavoprotein subunit alpha, mitochondrial", "Electron transfer flavoprotein subunit beta", "Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial", "Elongation factor 1-alpha 2", "Elongation factor 1-beta", "Elongation factor 1-delta", "Elongation factor 2", "Elongation factor Ts, mitochondrial", "Elongation factor Tu, mitochondrial", "Elongation factor-like GTPase 1", "Elongator complex protein 1", "Elongator complex protein 3", "Elongin-B", "Elongin-C", "Endodeoxyribonuclease", "Endoplasmic reticulum aminopeptidase 1", "Endoplasmic reticulum metallopeptidase 1", "Endoplasmic reticulum protein SC65", "Endoplasmic reticulum resident protein 29", "Endoplasmin", "Endoribonuclease", "Endoribonuclease Dicer", "Endothelin-converting enzyme 1", "Enhancer of mRNA-decapping protein 4", "Enhancer of rudimentary homolog", "Enoyl-CoA delta isomerase 1, mitochondrial", "Enoyl-CoA delta isomerase 2, mitochondrial", "Enoyl-CoA hydratase, mitochondrial", "Enzyme", "Enzyme modulator", "Epidermal growth factor receptor substrate 15", "Epidermal growth factor receptor substrate 15-like 1", "Epigenetic regulator", "Epimerase/racemase", "Epiplakin", "Equilibrative nucleoside transporter 1", "Eraser", "Erythrocyte band 7 integral membrane protein", "Esterase", "Ethylmalonyl-CoA decarboxylase", "Eukaryotic peptide chain release factor GTP-binding subunit ERF3A", "Eukaryotic peptide chain release factor subunit 1", "Eukaryotic translation initiation factor 2 subunit 1", "Eukaryotic translation initiation factor 2 subunit 2", "Eukaryotic translation initiation factor 2A", "Eukaryotic translation initiation factor 2D", "Eukaryotic translation initiation factor 3 subunit A", "Eukaryotic translation initiation factor 3 subunit B", "Eukaryotic translation initiation factor 3 subunit D", "Eukaryotic translation initiation factor 3 subunit E", "Eukaryotic translation initiation factor 3 subunit F", "Eukaryotic translation initiation factor 3 subunit H", "Eukaryotic translation initiation factor 3 subunit I", "Eukaryotic translation initiation factor 3 subunit J", "Eukaryotic translation initiation factor 3 subunit L", "Eukaryotic translation initiation factor 4 gamma 1", "Eukaryotic translation initiation factor 4 gamma 2", "Eukaryotic translation initiation factor 4 gamma 3", "Eukaryotic translation initiation factor 4B", "Eukaryotic translation initiation factor 4E", "Eukaryotic translation initiation factor 4H", "Eukaryotic translation initiation factor 5", "Eukaryotic translation initiation factor 5A-1", "Eukaryotic translation initiation factor 5B", "Eukaryotic translation initiation factor 6", "Exocyst complex component 1", "Exocyst complex component 4", "Exocyst complex component 5", "Exocyst complex component 7", "Exodeoxyribonuclease", "Exonuclease 1", "Exoribonuclease", "Exosome complex component MTR3", "Exosome complex component RRP40", "Exosome complex component RRP41", "Exosome complex component RRP42", "Exosome complex component RRP43", "Exosome complex component RRP46", "Exosome complex exonuclease RRP44", "Exportin-1", "Exportin-2", "Exportin-5", "Exportin-7", "Exportin-T", "Extracellular matrix glycoprotein", "Extracellular matrix structural protein", "Extracellular structure", "Ezrin", "F-actin-capping protein subunit alpha-1", "F-actin-capping protein subunit beta", "F-type ATPase", "F-type and V-type ATPases", "FACT complex subunit SPT16", "FAD-dependent oxidoreductase domain-containing protein 1", "FRAP subfamily", "Far upstream element-binding protein 1", "Far upstream element-binding protein 2", "Far upstream element-binding protein 3", "Farnesyl pyrophosphate synthase", "Fascin", "Fatty acid synthase", "Ferrochelatase, mitochondrial", "Flap endonuclease 1", "Flavin reductase (NADPH)", "Folate transporter 1", "Forkhead box protein C1", "Fragile X mental retardation syndrome-related protein 1", "Fragile X mental retardation syndrome-related protein 2", "Fumarate hydratase, mitochondrial", "G patch domain-containing protein 4", "G-patch domain and KOW motifs-containing protein", "G-protein", "G-protein coupled receptor", "G-protein modulator", "G-rich sequence factor 1", "G2/mitotic-specific cyclin-B1", "GDP-mannose 4,6 dehydratase", "GMP synthase [glutamine-hydrolyzing]", "GPI-anchor transamidase", "GSK family", "GSK subfamily", "GTP-binding nuclear protein Ran", "GTP-binding protein 1", "GTP-binding protein Rheb", "GTPase Era, mitochondrial", "GTPase-activating protein and VPS9 domain-containing protein 1", "Galactokinase", "Galactosidase", "Galectin-3", "Gamma-adducin", "Gamma-aminobutyric acid receptor-associated protein-like 2", "Gamma-glutamyl hydrolase", "Gamma-taxilin", "Gamma-tubulin complex component 2", "Gamma-tubulin complex component 3", "Ganglioside GM2 activator", "General transcription factor 3C polypeptide 3", "General transcription factor IIF subunit 1", "General transcription factor IIF subunit 2", "General vesicular transport factor p115", "Glia maturation factor beta", "Glucosamine-6-phosphate isomerase 1", "Glucose-6-phosphate 1-dehydrogenase", "Glucose-6-phosphate isomerase", "Glucosidase", "Glucosidase 2 subunit beta", "Glutamate dehydrogenase 1, mitochondrial", "Glutamate--cysteine ligase regulatory subunit", "Glutaminase kidney isoform, mitochondrial", "Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1", "Glutamine--tRNA ligase", "Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial", "Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial", "Glutaredoxin-3", "Glutaredoxin-related protein 5, mitochondrial", "Glutathione reductase, mitochondrial", "Glutathione synthetase", "Glyceraldehyde-3-phosphate dehydrogenase", "Glycerol-3-phosphate dehydrogenase, mitochondrial", "Glycerol-3-phosphate phosphatase", "Glycine dehydrogenase (decarboxylating), mitochondrial", "Glycine--tRNA ligase", "Glycogen debranching enzyme", "Glycogen phosphorylase, brain form", "Glycogen phosphorylase, liver form", "Glycogen synthase kinase-3 alpha", "Glycogen synthase kinase-3 beta", "Glycogenin-1", "Glycosidase", "Glycosyltransferase", "Glycylpeptide N-tetradecanoyltransferase 1", "Glyoxylate reductase/hydroxypyruvate reductase", "Golgi pH regulator family", "Golgi ph regulator b", "Group XV phospholipase A2", "Growth factor", "GrpE protein homolog 1, mitochondrial", "Guanine nucleotide-binding protein G(i) subunit alpha-1", "Guanine nucleotide-binding protein G(i) subunit alpha-2", "Guanine nucleotide-binding protein G(k) subunit alpha", "Guanine nucleotide-binding protein subunit alpha-13", "Guanyl-nucleotide exchange factor", "H(+)/Cl(-) exchange transporter 3", "H/ACA ribonucleoprotein complex subunit 1", "H/ACA ribonucleoprotein complex subunit 2", "H/ACA ribonucleoprotein complex subunit 3", "HBS1-like protein", "HDAC class I", "HDAC class III", "HEAT repeat-containing protein 1", "HEAT repeat-containing protein 6", "HIV Tat-specific factor 1", "Haloacid dehalogenase-like hydrolase domain-containing 5", "Haloacid dehalogenase-like hydrolase domain-containing protein 2", "Heat shock protein 75 kDa, mitochondrial", "Heat shock protein HSP 90-alpha", "Heat shock protein HSP 90-beta", "Helicase", "Helix-turn-helix transcription factor", "Hepatoma-derived growth factor", "Hepatoma-derived growth factor-related protein 2", "Heterogeneous nuclear ribonucleoprotein F", "Heterogeneous nuclear ribonucleoprotein H", "Heterogeneous nuclear ribonucleoprotein H2", "Heterogeneous nuclear ribonucleoprotein H3", "Heterogeneous nuclear ribonucleoprotein K", "Heterogeneous nuclear ribonucleoprotein M", "Heterogeneous nuclear ribonucleoprotein Q", "Heterogeneous nuclear ribonucleoprotein R", "Heterotrimeric G-protein", "Hexokinase family", "Hexokinase-1", "Hexokinase-2", "High affinity cationic amino acid transporter 1", "High mobility group protein B1", "High mobility group protein B2", "High mobility group protein B3", "High mobility group protein HMG-I/HMG-Y", "Histidine triad nucleotide-binding protein 2, mitochondrial", "Histone", "Histone H1.0", "Histone H1.2", "Histone H1.3", "Histone H1.4", "Histone H1x", "Histone H2AX", "Histone H4", "Histone acetyltransferase KAT7", "Histone acetyltransferase type B catalytic subunit", "Histone chaperone ASF1A", "Histone deacetylase", "Histone deacetylase 2", "Histone deacetylase complex subunit SAP18", "Histone-arginine methyltransferase CARM1", "Histone-lysine N-methyltransferase NSD2", "Histone-lysine N-methyltransferase SETD2", "Histone-lysine N-methyltransferase SMYD3", "Homeobox protein CDX-2", "Homeodomain transcription factor", "Hormone", "Hsp90 co-chaperone Cdc37", "Hsp90 family chaperone", "Hydrolase", "Hydroxylase", "Hydroxymethylglutaryl-CoA lyase, mitochondrial", "Hypoxanthine-guanine phosphoribosyltransferase", "ILK subfamily", "Immune response", "Immunoglobulin fold transcription factor", "Immunoglobulin-binding protein 1", "Importin subunit alpha-1", "Importin subunit alpha-4", "Importin subunit alpha-5", "Importin subunit alpha-7", "Importin subunit beta-1", "Importin-4", "Importin-5", "Importin-7", "Importin-8", "Importin-9", "Inactive tyrosine-protein kinase 7", "Induced myeloid leukemia cell differentiation protein Mcl-1", "Inorganic pyrophosphatase", "Inorganic pyrophosphatase 2, mitochondrial", "Inosine triphosphate pyrophosphatase", "Inosine-5'-monophosphate dehydrogenase 1", "Inosine-5'-monophosphate dehydrogenase 2", "Insulin-degrading enzyme", "Insulin-like growth factor 2 mRNA-binding protein 1", "Insulin-like growth factor 2 mRNA-binding protein 2", "Insulin-like growth factor 2 mRNA-binding protein 3", "Integrin beta-1", "Integrin-linked kinase-associated serine/threonine phosphatase 2C", "Integrin-linked protein kinase", "Interferon-induced, double-stranded rna-activated protein kinase", "Interferon-inducible double-stranded rna-dependent protein kinase activator a", "Interleukin enhancer-binding factor 3", "Intermediate filament", "Intermediate filament binding protein", "Intracellular calcium-sensing protein", "Intracellular chloride channel (clic) family", "Intracellular chloride channel (icc) family", "Ion channel", "Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial", "Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial", "Isoleucine--tRNA ligase, cytoplasmic", "Isoleucine--tRNA ligase, mitochondrial", "Isomerase", "Isopentenyl-diphosphate Delta-isomerase 1", "Isovaleryl-CoA dehydrogenase, mitochondrial", "Jumonji domain-containing", "KH domain-containing, RNA-binding, signal transduction-associated protein 1", "KH domain-containing, RNA-binding, signal transduction-associated protein 3", "KRAB box transcription factor", "Ketosamine-3-kinase", "Kinase", "Kinase activator", "Kinase inhibitor", "Kinase modulator", "Kinesin-1 heavy chain", "Kinesin-like protein KIF11", "Kinesin-like protein KIF20A", "Kinesin-like protein KIF22", "Kinesin-like protein KIF23", "Kinesin-like protein KIF2A", "Kinesin-like protein KIF2C", "Kinesin-like protein KIF3A", "Kinesin-like protein KIFC1", "Kynurenine--oxoglutarate transaminase 3", "L-2-hydroxyglutarate dehydrogenase, mitochondrial", "L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase", "L-lactate dehydrogenase A chain", "L-lactate dehydrogenase B chain", "LIM domain and actin-binding protein 1", "LU7TM family", "La-related protein 1", "La-related protein 4", "La-related protein 4B", "La-related protein 7", "Lamin-B receptor", "Lamina-associated polypeptide 2, isoform alpha", "Lanosterol 14-alpha demethylase", "Large proline-rich protein BAG6", "Lathosterol oxidase", "Legumain", "Lethal(2) giant larvae protein homolog 1", "Leucine-rich repeat-containing protein 47", "Leucyl-cystinyl aminopeptidase", "Ligase", "Lipase", "Lipid kinase", "Lipoma-preferred partner", "Lon protease homolog, mitochondrial", "Long-chain fatty acid transport protein 4", "Long-chain-fatty-acid--CoA ligase 1", "Long-chain-fatty-acid--CoA ligase 3", "Long-chain-fatty-acid--CoA ligase 4", "Lupus La protein", "Lyase", "Lymphokine-activated killer t-cell-originated protein kinase", "Lysine demethylase", "Lysine--tRNA ligase", "Lysine-specific demethylase", "Lysine-specific demethylase 3B", "Lysine-specific histone demethylase 1A", "Lysine-specific histone demethylase 1B", "Lysophosphatidic acid phosphatase type 6", "Lysophosphatidylcholine acyltransferase 1", "Lysophospholipid acyltransferase 7", "Lysosomal Pro-X carboxypeptidase", "Lysosomal acid lipase/cholesteryl ester hydrolase", "Lysosomal acid phosphatase", "Lysosomal alpha-glucosidase", "Lysosomal protective protein", "Lysosomal thioesterase PPT2", "Lysosome membrane protein 2", "Lysosome-associated membrane glycoprotein 1", "Lysosome-associated membrane glycoprotein 2", "MAGUK p55 subfamily member 2", "MAGUK p55 subfamily member 6", "MAPK family", "MAST family", "MCU family", "MHC class II regulatory factor RFX1", "MLK family", "MMS19 nucleotide excision repair protein homolog", "MST subfamily", "Magnesium transporter protein 1", "Major histocompatibility complex antigen", "Malate dehydrogenase, cytoplasmic", "Malate dehydrogenase, mitochondrial", "Malignant T-cell-amplified sequence 1", "Mannose-6-phosphate isomerase", "Medium-chain specific acyl-CoA dehydrogenase, mitochondrial", "Melanoma inhibitory activity protein 2", "Melanoma-associated antigen D2", "Membrane trafficking regulatory protein", "Membrane-associated progesterone receptor component 1", "Membrane-associated progesterone receptor component 2", "Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase", "Metalloprotease", "Metastasis-associated protein MTA1", "Metastasis-associated protein MTA2", "Methionine aminopeptidase 1", "Methionine--tRNA ligase, mitochondrial", "Methyl-CpG-binding domain", "Methyl-CpG-binding protein 2", "Methyl-lysine/arginine binding protein", "Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial", "Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial", "Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial", "Methylmalonyl-CoA mutase, mitochondrial", "Methylosome subunit pICln", "Methylsterol monooxygenase 1", "Methyltransferase", "Microfibrillar-associated protein 1", "Microsomal glutathione S-transferase 2", "Microsomal glutathione S-transferase 3", "Microtubule binding motor protein", "Microtubule family cytoskeletal protein", "Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5", "Microtubule-associated protein 1B", "Microtubule-associated protein 1S", "Microtubule-associated protein RP/EB family member 1", "Microtubule-associated protein RP/EB family member 2", "Minor histocompatibility antigen H13", "Miscellaneous SLC25 mitochondrial transporters", "Mitochondrial 2-oxoglutarate/malate carrier protein", "Mitochondrial Rho GTPase 1", "Mitochondrial amino acid transporter subfamily", "Mitochondrial cardiolipin hydrolase", "Mitochondrial carnitine/acylcarnitine carrier protein", "Mitochondrial carrier homolog 1", "Mitochondrial carrier homolog 2", "Mitochondrial di- and tri-carboxylic acid transporter subfamily", "Mitochondrial dicarboxylate carrier", "Mitochondrial folate transporter/carrier", "Mitochondrial glutamate carrier 1", "Mitochondrial import receptor subunit TOM20 homolog", "Mitochondrial import receptor subunit TOM40 homolog", "Mitochondrial inner membrane protein OXA1L", "Mitochondrial intermediate peptidase", "Mitochondrial nucleotide transporter subfamily", "Mitochondrial ornithine transporter 1", "Mitochondrial phosphate transporters", "Mitochondrial proton/calcium exchanger protein", "Mitochondrial-processing peptidase subunit alpha", "Mitochondrial-processing peptidase subunit beta", "Mitofusin-1", "Mitofusin-2", "Mitogen-activated protein kinase 1", "Mitogen-activated protein kinase 14", "Mitotic checkpoint protein BUB3", "Mitotic checkpoint serine/threonine-protein kinase bub1", "Mitotic checkpoint serine/threonine-protein kinase bub1 beta", "Moesin", "Molybdate-anion transporter", "Monoacylglycerol lipase ABHD12", "Monoacylglycerol lipase ABHD6", "Monocarboxylate transporter 1", "Monofunctional C1-tetrahydrofolate synthase, mitochondrial", "Mortality factor 4-like protein 1", "Mpv17-like protein 2", "Multidrug resistance protein 1", "Multifunctional protein ADE2", "Muscleblind-like protein 1", "Mutase", "Myb-binding protein 1A", "Myelin expression factor 2", "Myosin light polypeptide 6", "Myosin phosphatase Rho-interacting protein", "N(G),N(G)-dimethylarginine dimethylaminohydrolase 1", "N-acetyl-D-glucosamine kinase", "N-acetylgalactosaminyltransferase 7", "N-acetylglucosamine-6-sulfatase", "N-alpha-acetyltransferase 10", "N-alpha-acetyltransferase 15, NatA auxiliary subunit", "N-alpha-acetyltransferase 25, NatB auxiliary subunit", "N-alpha-acetyltransferase 35, NatC auxiliary subunit", "N-alpha-acetyltransferase 50", "N-terminal Xaa-Pro-Lys N-methyltransferase 1", "NAD kinase 2, mitochondrial", "NAD(P) transhydrogenase, mitochondrial", "NAD-dependent malic enzyme, mitochondrial", "NAD-dependent protein deacetylase sirtuin-1", "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial", "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13", "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2", "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5", "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8", "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial", "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial", "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4", "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial", "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9", "NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial", "NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial", "NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial", "NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial", "NADPH:adrenodoxin oxidoreductase, mitochondrial", "NEDD8-activating enzyme E1 catalytic subunit", "NEDD8-activating enzyme E1 regulatory subunit", "NEK family", "NF-kappa-B-repressing factor", "NHP2-like protein 1", "NRBP family", "NSFL1 cofactor p47", "Na+/K+-ATPases", "Nardilysin", "Neuferricin", "Neurolysin, mitochondrial", "Neutral alpha-glucosidase AB", "Neutral amino acid transporter B(0)", "Nibrin", "Nicotinamide phosphoribosyltransferase", "Nischarin", "Non-POU domain-containing octamer-binding protein", "Non-motor actin binding protein", "Non-motor microtubule binding protein", "Non-protein kinase", "Nuclear RNA export factor 1", "Nuclear cap-binding protein subunit 1", "Nuclear cap-binding protein subunit 2", "Nuclear factor NF-kappa-B p105 subunit", "Nuclear migration protein nudC", "Nuclear pore complex protein Nup107", "Nuclear pore complex protein Nup153", "Nuclear pore complex protein Nup160", "Nuclear pore complex protein Nup214", "Nuclear pore complex protein Nup85", "Nuclear pore complex protein Nup88", "Nuclear pore complex protein Nup93", "Nuclear pore complex protein Nup98-Nup96", "Nuclear pore glycoprotein p62", "Nuclear pore membrane glycoprotein 210", "Nuclear receptor coactivator 5", "Nuclear receptor-binding protein", "Nuclease", "Nucleic acid binding", "Nucleobindin-1", "Nucleobindin-2", "Nucleolar complex protein 4 homolog", "Nucleolar protein 14", "Nucleolar protein 56", "Nucleolar protein 58", "Nucleolar protein 6", "Nucleolar protein 9", "Nucleolin", "Nucleophosmin", "Nucleoporin Nup37", "Nucleoporin SEH1", "Nucleoporin p54", "Nucleoside diphosphate kinase A", "Nucleoside diphosphate kinase B", "Nucleoside kinase", "Nucleosome assembly protein 1-like 1", "Nucleosome assembly protein 1-like 4", "Nucleotide kinase", "Nucleotide phosphatase", "Nucleotidyltransferase", "NudC domain-containing protein 2", "OCIA domain-containing protein 1", "Obg-like ATPase 1", "Occludin", "Ornithine aminotransferase, mitochondrial", "Other 7TM proteins", "Other group", "Other small molecule kinase", "Oxidase", "Oxidoreductase", "Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial", "Oxygenase", "P-type ATPases", "P38 subfamily", "P53-like transcription factor", "PAKA subfamily", "PASK subfamily", "PC4 and SFRS1-interacting protein", "PDHK family", "PDZ and LIM domain protein 1", "PDZ and LIM domain protein 5", "PDZ and LIM domain protein 7", "PEK family", "PHD finger protein 6", "PI3/PI4 kinase family", "PIKK family", "PIN2/TERF1-interacting telomerase inhibitor 1", "PKA family", "PKN family", "PLK family", "Palmitoyl-protein thioesterase 1", "Pantothenate kinase 4", "Paraspeckle component 1", "Pas domain-containing serine/threonine-protein kinase", "Pentatricopeptide repeat-containing protein 1, mitochondrial", "Peptidase M20 domain-containing protein 2", "Peptidyl-prolyl cis-trans isomerase FKBP1A", "Peptidyl-prolyl cis-trans isomerase FKBP4", "Peptidyl-prolyl cis-trans isomerase FKBP5", "Peptidyl-prolyl cis-trans isomerase-like 1", "Perilipin-3", "Periodic tryptophan protein 1 homolog", "Peripheral plasma membrane protein cask", "Peroxidase", "Peroxiredoxin-2", "Peroxiredoxin-4", "Peroxiredoxin-6", "Peroxisomal acyl-coenzyme A oxidase 1", "Peroxisomal acyl-coenzyme A oxidase 3", "Peroxisomal biogenesis factor 19", "Peroxisomal membrane protein 2", "Peroxisomal membrane protein PEX14", "Peroxisomal membrane protein PMP34", "Peroxisomal targeting signal 1 receptor", "Peroxisomal trans-2-enoyl-CoA reductase", "Pescadillo homolog", "Phenylalanine--tRNA ligase beta subunit", "Phosphatase", "Phosphatase activator", "Phosphatase inhibitor", "Phosphatase modulator", "Phosphate carrier protein, mitochondrial", "Phosphatidylethanolamine-binding protein 1", "Phosphatidylinositol 3-kinase catalytic subunit type 3", "Phosphatidylinositol 4-kinase beta", "Phosphatidylinositol 4-kinase type 2-alpha", "Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma", "Phosphatidylinositol transfer protein alpha isoform", "Phosphatidylinositol transfer protein beta isoform", "Phosphatidylinositol-binding clathrin assembly protein", "Phosphatidylserine synthase 1", "Phosphodiesterase", "Phosphoenolpyruvate carboxykinase [GTP] family", "Phosphoenolpyruvate carboxykinase [gtp], mitochondrial", "Phosphofructokinase type A (PFKA) family", "Phosphoglycerate kinase 1", "Phosphoglycerate kinase family", "Phospholipase", "Phospholipase A-2-activating protein", "Phosphoribosyl pyrophosphate synthase-associated protein 1", "Phosphoribosyl pyrophosphate synthase-associated protein 2", "Phosphorylase", "Pirin", "Plasma membrane calcium-transporting ATPase 1", "Plasminogen activator inhibitor 1 RNA-binding protein", "Plastin-3", "Plectin", "Pogo transposable element with ZNF domain", "Poly(A) RNA polymerase, mitochondrial", "Poly(A)-specific ribonuclease PARN", "Poly(rC)-binding protein 1", "Poly(rC)-binding protein 2", "Polycomb protein SUZ12", "Polyglutamine-binding protein 1", "Polymerase", "Polymerase delta-interacting protein 3", "Polypeptide N-acetylgalactosaminyltransferase 2", "Polyribonucleotide nucleotidyltransferase 1, mitochondrial", "Porphobilinogen deaminase", "Pre-mRNA-processing factor 17", "Pre-mRNA-processing factor 39", "Pre-mRNA-processing factor 6", "Pre-mRNA-processing-splicing factor 8", "Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15", "Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16", "Pre-mRNA-splicing factor RBM22", "Pre-mRNA-splicing factor SPF27", "Pre-mRNA-splicing factor SYF1", "Prefoldin subunit 2", "Prefoldin subunit 3", "Prefoldin subunit 5", "Presequence protease, mitochondrial", "Primase", "Probable ATP-dependent RNA helicase DHX37", "Probable RNA-binding protein 19", "Probable U3 small nucleolar RNA-associated protein 11", "Probable cysteine--tRNA ligase, mitochondrial", "Probable global transcription activator SNF2L1", "Probable glutamate--tRNA ligase, mitochondrial", "Probable glutathione peroxidase 8", "Probable leucine--tRNA ligase, mitochondrial", "Probable serine carboxypeptidase CPVL", "Probable tRNA N6-adenosine threonylcarbamoyltransferase", "Procollagen galactosyltransferase 1", "Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1", "Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2", "Programmed cell death 6-interacting protein", "Programmed cell death protein 4", "Programmed cell death protein 5", "Prolactin regulatory element-binding protein", "Proliferating cell nuclear antigen", "Prolyl 3-hydroxylase 1", "Prolyl endopeptidase", "Propionyl-CoA carboxylase alpha chain, mitochondrial", "Propionyl-CoA carboxylase beta chain, mitochondrial", "Prostaglandin E synthase 2", "Prostaglandin E synthase 3", "Prostaglandin reductase 1", "Prostaglandin reductase 2", "Prostaglandin reductase 3", "Protease", "Protease inhibitor", "Proteasome inhibitor PI31 subunit", "Protein AATF", "Protein BUD31 homolog", "Protein CMSS1", "Protein DDI1 homolog 2", "Protein ERGIC-53", "Protein Hook homolog 3", "Protein NDRG3", "Protein PRRC2A", "Protein PRRC2C", "Protein RRP5 homolog", "Protein Red", "Protein S100-A10", "Protein S100-A11", "Protein S100-A13", "Protein SCO1 homolog, mitochondrial", "Protein SCO2 homolog, mitochondrial", "Protein SET", "Protein Wiz", "Protein XRP2", "Protein arginine N-methyltransferase 1", "Protein arginine N-methyltransferase 3", "Protein arginine N-methyltransferase 5", "Protein arginine methyltransferase", "Protein farnesyltransferase subunit beta", "Protein gpr107", "Protein kinase", "Protein kinase C and casein kinase substrate in neurons protein 2", "Protein kinase C and casein kinase substrate in neurons protein 3", "Protein methyltransferase", "Protein pelota homolog", "Protein phosphatase", "Protein phosphatase 1G", "Protein phosphatase methylesterase 1", "Protein polybromo-1", "Protein quaking", "Protein regulator of cytokinesis 1", "Protein transport protein Sec23A", "Protein transport protein Sec23B", "Protein transport protein Sec24A", "Protein transport protein Sec24B", "Protein transport protein Sec24C", "Protein transport protein Sec31A", "Protein transport protein Sec61 subunit alpha isoform 1", "Protein tweety homolog 3", "Protein unc-119 homolog A", "Protein unc-119 homolog B", "Protein-L-isoaspartate(D-aspartate) O-methyltransferase", "Protein/nucleic acid deglycase DJ-1", "Pterin-4-alpha-carbinolamine dehydratase", "Pumilio homolog 1", "Purine nucleoside phosphorylase", "Puromycin-sensitive aminopeptidase", "Putative oxidoreductase GLYR1", "Putative phospholipase B-like 2", "Pyridoxal kinase", "Pyridoxine kinase family", "Pyrophosphatase", "Pyruvate carboxylase, mitochondrial", "Pyruvate kinase pkm", "RAD53 family", "RIPK family", "RNA 3'-terminal phosphate cyclase-like protein", "RNA binding motif protein, X-linked-like-1", "RNA binding protein", "RNA helicase", "RNA-binding motif protein, X chromosome", "RNA-binding protein 12", "RNA-binding protein 12B", "RNA-binding protein 14", "RNA-binding protein 26", "RNA-binding protein 27", "RNA-binding protein 3", "RNA-binding protein 4", "RNA-binding protein 4B", "RNA-binding protein EWS", "RNA-binding protein FUS", "RNA-binding protein with multiple splicing", "RNA-binding protein with serine-rich domain 1", "ROCK subfamily", "RSK family", "RSK subfamily", "Rab GDP dissociation inhibitor alpha", "Rab GDP dissociation inhibitor beta", "Rab GTPase-activating protein 1", "Rab proteins geranylgeranyltransferase component A 2", "Rab3 GTPase-activating protein non-catalytic subunit", "Rac-beta serine/threonine-protein kinase", "Radixin", "RalBP1-associated Eps domain-containing protein 1", "Ran GTPase-activating protein 1", "Ran-binding protein 3", "Ran-binding protein 9", "Ran-specific GTPase-activating protein", "Rap guanine nucleotide exchange factor 2", "Ras GTPase-activating protein-binding protein 1", "Ras GTPase-activating protein-binding protein 2", "Ras GTPase-activating-like protein IQGAP1", "Ras-related C3 botulinum toxin substrate 1", "Ras-related protein Ral-A", "Ras-related protein Ral-B", "Reader", "Receptor", "Receptor expression-enhancing protein 5", "Receptor-interacting serine/threonine-protein kinase 1", "Reductase", "Regulation of nuclear pre-mRNA domain-containing protein 1B", "Regulation of nuclear pre-mRNA domain-containing protein 2", "Regulator of nonsense transcripts 1", "Rel homology transcription factor", "Remodeling and spacing factor 1", "Replication factor C subunit 2", "Replication factor C subunit 3", "Replication factor C subunit 4", "Replication factor C subunit 5", "Replication origin binding protein", "Replication protein A 70 kDa DNA-binding subunit", "Reticulocalbin-1", "Reticulocalbin-2", "Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta", "Retinoid-inducible serine carboxypeptidase", "Retinol dehydrogenase 11", "Retinol dehydrogenase 14", "Rho GDP-dissociation inhibitor 1", "Rho-associated protein kinase 2", "Rho-related GTP-binding protein RhoG", "Ribonuclease H2 subunit A", "Ribonuclease P protein subunit p30", "Ribonuclease inhibitor", "Ribonucleoprotein", "Ribonucleoprotein PTB-binding 1", "Ribonucleoside-diphosphate reductase large subunit", "Ribonucleoside-diphosphate reductase subunit M2", "Ribose-phosphate pyrophosphokinase 2", "Ribosomal L1 domain-containing protein 1", "Ribosomal RNA small subunit methyltransferase NEP1", "Ribosomal protein", "Ribosomal protein s6 kinase alpha-1", "Ribosomal protein s6 kinase alpha-3", "Ribosome biogenesis protein BOP1", "Ribosome biogenesis protein BRX1 homolog", "Ribosome biogenesis regulatory protein homolog", "Ribosome maturation protein SBDS", "Ribosome production factor 2 homolog", "S-adenosylhomocysteine hydrolase-like protein 1", "S-adenosylmethionine mitochondrial carrier protein", "S-adenosylmethionine synthase isoform type-2", "S-formylglutathione hydrolase", "S-methyl-5'-thioadenosine phosphorylase", "S-phase kinase-associated protein 1", "SEC23-interacting protein", "SET domain", "SLC superfamily of solute carriers", "SLC1 family of amino acid transporters", "SLC16 family of monocarboxylate transporters", "SLC19 family of vitamin transporters", "SLC2 family of hexose and sugar alcohol transporters", "SLC22 family of organic cation and anion transporters", "SLC25 family of mitochondrial transporters", "SLC27 family of fatty acid transporters", "SLC28 and SLC29 families of nucleoside transporters", "SLC29 family", "SLC3 and SLC7 families of heteromeric amino acid transporters (HATs)", "SLC3 family", "SLC33 acetylCoA transporter", "SLC35 family of nucleotide sugar transporters", "SLC55 Mitochondrial cation/proton exchangers", "SLC56 Sideroflexins", "SLC58 MagT-like magnesium transporter family", "SLC61 Molybdate transporter family", "SLC64 Golgi Ca2+/H+ exchangers", "SLC7 family", "SLK subfamily", "SNARE protein", "SNW domain-containing protein 1", "SRPK family", "STAM-binding protein", "STE group", "STE20 family", "STE7 family", "SUMO-activating enzyme subunit 1", "SUMO-activating enzyme subunit 2", "SUN domain-containing protein 1", "SURP and G-patch domain-containing protein 1", "SURP and G-patch domain-containing protein 2", "SWI/SNF complex subunit SMARCC1", "SWI/SNF complex subunit SMARCC2", "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1", "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5", "Sarcoplasmic/endoplasmic reticulum calcium ATPase 2", "Scavenger receptor class B member 1", "Sec1 family domain-containing protein 1", "Secretory carrier-associated membrane protein 1", "Secretory carrier-associated membrane protein 2", "Secretory carrier-associated membrane protein 3", "Selenide, water dikinase 1", "Selenocysteine-specific elongation factor", "Sentrin-specific protease 3", "Septin-11", "Septin-2", "Septin-7", "Septin-9", "Serine hydroxymethyltransferase, cytosolic", "Serine hydroxymethyltransferase, mitochondrial", "Serine palmitoyltransferase 1", "Serine palmitoyltransferase 2", "Serine protease", "Serine protease inhibitor", "Serine--tRNA ligase, cytoplasmic", "Serine--tRNA ligase, mitochondrial", "Serine/arginine repetitive matrix protein 1", "Serine/arginine-rich splicing factor 1", "Serine/arginine-rich splicing factor 10", "Serine/arginine-rich splicing factor 11", "Serine/arginine-rich splicing factor 3", "Serine/arginine-rich splicing factor 5", "Serine/arginine-rich splicing factor 6", "Serine/arginine-rich splicing factor 7", "Serine/arginine-rich splicing factor 9", "Serine/threonine-protein kinase 4", "Serine/threonine-protein kinase chk2", "Serine/threonine-protein kinase greatwall", "Serine/threonine-protein kinase mtor", "Serine/threonine-protein kinase n1", "Serine/threonine-protein kinase n2", "Serine/threonine-protein kinase nek9", "Serine/threonine-protein kinase pak 1", "Serine/threonine-protein kinase pak 2", "Serine/threonine-protein kinase plk1", "Serine/threonine-protein kinase prp4 homolog", "Serine/threonine-protein kinase vrk1", "Serine/threonine-protein kinase wnk1", "Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform", "Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform", "Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform", "Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform", "Serine/threonine-protein phosphatase 2A activator", "Serine/threonine-protein phosphatase PP1-alpha catalytic subunit", "Serine/threonine-protein phosphatase PP1-beta catalytic subunit", "Serpin B6", "Serpin H1", "Sex comb on midleg-like protein 2", "Sialic acid synthase", "Sideroflexin-1", "Sigma intracellular receptor 2", "Signal peptidase complex catalytic subunit SEC11A", "Signal peptidase complex subunit 2", "Signal peptide peptidase-like 2A", "Signal recognition particle 14 kDa protein", "Signal recognition particle 54 kDa protein", "Signal recognition particle 9 kDa protein", "Signal recognition particle receptor subunit alpha", "Signal recognition particle subunit SRP68", "Signal transducer and activator of transcription 1-alpha/beta", "Signal transducer and activator of transcription 3", "Signaling", "Single-stranded DNA-binding protein, mitochondrial", "Sister chromatid cohesion protein PDS5 homolog A", "Sister chromatid cohesion protein PDS5 homolog B", "Small GTPase", "Small nuclear ribonucleoprotein E", "Small nuclear ribonucleoprotein Sm D1", "Small nuclear ribonucleoprotein Sm D2", "Small nuclear ribonucleoprotein Sm D3", "Sodium/potassium-transporting ATPase subunit alpha-1", "Sodium/potassium-transporting ATPase subunit beta-3", "Solute carrier family 2, facilitated glucose transporter member 1", "Solute carrier family 25 member 33", "Solute carrier family 35 member F2", "Something about silencing protein 10", "Sorbitol dehydrogenase", "Sortilin", "Sorting nexin-1", "Sorting nexin-2", "Spermatid perinuclear RNA-binding protein", "Spermidine synthase", "Splicing factor 1", "Splicing factor 3A subunit 1", "Splicing factor 3A subunit 2", "Splicing factor 3A subunit 3", "Splicing factor 3B subunit 1", "Splicing factor 3B subunit 3", "Splicing factor 45", "Splicing factor U2AF 35 kDa subunit", "Splicing factor, arginine/serine-rich 15", "Splicing factor, proline- and glutamine-rich", "Splicing factor, suppressor of white-apricot homolog", "Splicing regulatory glutamine/lysine-rich protein 1", "Squalene monooxygenase", "Squamous cell carcinoma antigen recognized by T-cells 3", "Src substrate cortactin", "Srsf protein kinase 1", "Staphylococcal nuclease domain-containing protein 1", "Ste20-like serine/threonine-protein kinase", "Sterol O-acyltransferase 1", "Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating", "Stomatin-like protein 2, mitochondrial", "Storage", "Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial", "Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial", "Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial", "Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial", "Succinate-semialdehyde dehydrogenase, mitochondrial", "Superoxide dismutase [Mn], mitochondrial", "Surfeit locus protein 4", "Surfeit locus protein 6", "Survival motor neuron protein", "Synaptic functional regulator FMR1", "Synaptic vesicle glycoprotein 2A", "Synaptogyrin-2", "Synaptojanin-2-binding protein", "Synaptosomal-associated protein 23", "Synaptosomal-associated protein 29", "Syntaxin-12", "Syntaxin-18", "Syntaxin-5", "Syntaxin-7", "Syntaxin-binding protein 3", "T-complex protein 1 subunit alpha", "T-complex protein 1 subunit beta", "T-complex protein 1 subunit delta", "T-complex protein 1 subunit epsilon", "T-complex protein 1 subunit eta", "T-complex protein 1 subunit gamma", "T-complex protein 1 subunit theta", "T-complex protein 1 subunit zeta", "TATA-binding protein-associated factor 2N", "TBC1 domain family member 10B", "TBC1 domain family member 13", "TBC1 domain family member 15", "TBC1 domain family member 4", "TBC1 domain family member 9B", "THO complex subunit 1", "THO complex subunit 2", "THO complex subunit 3", "THO complex subunit 4", "TK group", "TKL group", "TOPK family", "TP53-binding protein 1", "Target of EGR1 protein 1", "Targeting protein for Xklp2", "Thimet oligopeptidase", "Thioredoxin domain-containing protein 12", "Thioredoxin domain-containing protein 17", "Thioredoxin reductase 1, cytoplasmic", "Thioredoxin-dependent peroxide reductase, mitochondrial", "Threonine--tRNA ligase, cytoplasmic", "Threonine--tRNA ligase, mitochondrial", "Thymidine kinase family", "Thymidine kinase, cytosolic", "Thymidylate kinase", "Thymidylate kinase family", "Thymidylate synthase", "Thyroid hormone receptor-associated protein 3", "Tight junction", "Tight junction protein ZO-1", "Transaminase", "Transcription activator BRG1", "Transcription cofactor", "Transcription elongation factor A protein 1", "Transcription elongation factor SPT6", "Transcription elongation regulator 1", "Transcription factor", "Transcription initiation factor IIB", "Transcriptional activator protein Pur-alpha", "Transcriptional repressor p66-alpha", "Transcriptional repressor p66-beta", "Transferase", "Transferrin receptor protein 1", "Transformer-2 protein homolog alpha", "Transformer-2 protein homolog beta", "Transforming protein RhoA", "Transgelin-2", "Transketolase", "Translation elongation factor", "Translation factor", "Translation initiation factor", "Translation release factor", "Translationally-controlled tumor protein", "Translocation protein SEC63 homolog", "Translocon-associated protein subunit alpha", "Transmembrane 9 superfamily member 3", "Transmembrane emp24 domain-containing protein 10", "Transmembrane emp24 domain-containing protein 2", "Transmembrane emp24 domain-containing protein 5", "Transmembrane emp24 domain-containing protein 7", "Transmembrane emp24 domain-containing protein 9", "Transmembrane protein 165", "Transport and Golgi organization protein 1 homolog", "Transporter", "Transportin-1", "Transportin-2", "Transportin-3", "Tricarboxylate transport protein, mitochondrial", "Trifunctional enzyme subunit alpha, mitochondrial", "Trifunctional enzyme subunit beta, mitochondrial", "Trifunctional purine biosynthetic protein adenosine-3", "Triosephosphate isomerase", "Tripeptidyl-peptidase 1", "Tripeptidyl-peptidase 2", "Tropomodulin-1", "Tropomodulin-3", "Tropomyosin alpha-1 chain", "Tropomyosin alpha-3 chain", "Tropomyosin alpha-4 chain", "Tryptophan--tRNA ligase, cytoplasmic", "Tubulin", "Tubulin beta chain", "Tubulin beta-2A chain", "Tubulin beta-2B chain", "Tubulin beta-4A chain", "Tubulin beta-4B chain", "Tubulin beta-6 chain", "Tubulin-specific chaperone A", "Tubulin-specific chaperone C", "Tubulin-specific chaperone D", "Tubulin-specific chaperone E", "Tudor and KH domain-containing protein", "Tudor domain", "Tumor susceptibility gene 101 protein", "Twinfilin-1", "Twinfilin-2", "Type II PI4K subfamily", "Tyrosine--tRNA ligase, cytoplasmic", "Tyrosine--tRNA ligase, mitochondrial", "Tyrosine-protein kinase csk", "U1 small nuclear ribonucleoprotein 70 kDa", "U1 small nuclear ribonucleoprotein A", "U2 small nuclear ribonucleoprotein A'", "U2 small nuclear ribonucleoprotein B''", "U2 snRNP-associated SURP motif-containing protein", "U3 small nucleolar RNA-associated protein 14 homolog A", "U3 small nucleolar RNA-associated protein 6 homolog", "U3 small nucleolar ribonucleoprotein protein IMP3", "U3 small nucleolar ribonucleoprotein protein MPP10", "U4/U6 small nuclear ribonucleoprotein Prp3", "U4/U6 small nuclear ribonucleoprotein Prp31", "U4/U6 small nuclear ribonucleoprotein Prp4", "U4/U6.U5 tri-snRNP-associated protein 1", "U4/U6.U5 tri-snRNP-associated protein 2", "U6 snRNA-associated Sm-like protein LSm6", "U6 snRNA-associated Sm-like protein LSm7", "U6 snRNA-associated Sm-like protein LSm8", "UDP-glucose:glycoprotein glucosyltransferase 1", "UMP-CMP kinase", "UV excision repair protein RAD23 homolog A", "UV excision repair protein RAD23 homolog B", "Ubiquitin carboxyl-terminal hydrolase 10", "Ubiquitin carboxyl-terminal hydrolase 11", "Ubiquitin carboxyl-terminal hydrolase 14", "Ubiquitin carboxyl-terminal hydrolase 15", "Ubiquitin carboxyl-terminal hydrolase 47", "Ubiquitin carboxyl-terminal hydrolase 5", "Ubiquitin carboxyl-terminal hydrolase 7", "Ubiquitin carboxyl-terminal hydrolase isozyme L5", "Ubiquitin conjugation factor E4 B", "Ubiquitin thioesterase OTUB1", "Ubiquitin-conjugating enzyme E2 L3", "Ubiquitin-like modifier-activating enzyme 1", "Ubiquitin-like modifier-activating enzyme 6", "Ubiquitin-like modifier-activating enzyme ATG7", "Ubiquitin-protein ligase", "Unclassified protein", "Unconventional myosin-Ib", "Unconventional myosin-Id", "Unconventional myosin-VI", "V-type ATPase", "V-type proton ATPase 116 kDa subunit a isoform 1", "V-type proton ATPase 116 kDa subunit a isoform 2", "V-type proton ATPase catalytic subunit A", "V-type proton ATPase subunit B, brain isoform", "V-type proton ATPase subunit C 1", "V-type proton ATPase subunit D", "V-type proton ATPase subunit H", "V-type proton ATPase subunit d 1", "VRK family", "Vacuolar protein sorting-associated protein 18 homolog", "Vacuolar protein sorting-associated protein 26A", "Vacuolar protein sorting-associated protein 29", "Vacuolar protein sorting-associated protein 33A", "Vacuolar protein sorting-associated protein 33B", "Vacuolar protein sorting-associated protein 35", "Vacuolar protein sorting-associated protein 4B", "Vacuolar protein sorting-associated protein 52 homolog", "Vacuole membrane protein 1", "Very long-chain specific acyl-CoA dehydrogenase, mitochondrial", "Very-long-chain enoyl-CoA reductase", "Vesicle coat protein", "Vesicle transport through interaction with t-SNAREs homolog 1B", "Vesicle-associated membrane protein 7", "Vesicle-associated membrane protein-associated protein A", "Vesicle-associated membrane protein-associated protein B/C", "Vesicle-fusing ATPase", "Vesicular integral-membrane protein VIP36", "Vitamin K epoxide reductase complex subunit 1-like protein 1", "WD repeat and HMG-box DNA-binding protein 1", "WD repeat-containing protein 1", "WD repeat-containing protein 82", "WEE family", "WNK family", "Winged helix/forkhead transcription factor", "Writer", "X-ray repair cross-complementing protein 5", "X-ray repair cross-complementing protein 6", "Xaa-Pro dipeptidase", "YEATS domain-containing protein 4", "YLP motif-containing protein 1", "Zinc finger CCCH domain-containing protein 11A", "Zinc finger CCCH domain-containing protein 15", "Zinc finger CCCH domain-containing protein 7A", "Zinc finger CCHC domain-containing protein 8", "Zinc finger MYM-type protein 2", "Zinc finger RNA-binding protein", "Zinc finger protein 281", "Zinc finger protein 622", "Zinc finger protein ubi-d4", "Zinc finger transcription factor", "Zyxin", "[pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial", "c-Myc-binding protein", "eIF-2-alpha kinase activator GCN1", "eukaryotic two domain clade \"e\" sub-subfamily", "m7GpppX diphosphatase", "mRNA export factor", "mRNA polyadenylation factor", "mRNA processing factor", "mRNA splicing factor", "mRNA-decapping enzyme 1A", "rRNA 2'-O-methyltransferase fibrillarin", "tRNA (cytosine(34)-C(5))-methyltransferase"], "available_proteins": ["AARS", "AARS2", "AARSD1", "AASDHPPT", "AATF", "ABCB1", "ABCB10", "ABCB7", "ABCD3", "ABCF1", "ABCF2", "ABHD12", "ABHD6", "ACAA2", "ACAD9", "ACADM", "ACADVL", "ACAT1", "ACAT2", "ACBD5", "ACLY", "ACO1", "ACO2", "ACOT7", "ACOT8", "ACOT9", "ACOX1", "ACOX3", "ACP2", "ACP6", "ACSL1", "ACSL3", "ACSL4", "ACTR10", "ACTR1A", "ACTR2", "ACTR3", "ADA", "ADAR", "ADD1", "ADD3", "ADH5", "ADI1", "ADK", "ADPGK", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGL", "AHCY", "AHCYL1", "AIFM1", "AIMP1", "AIP", "AK1", "AK2", "AK4", "AK6", "AKR1A1", "AKR1B1", "AKR7A2", "AKT2", "ALDH18A1", "ALDH1B1", "ALDH2", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALG1", "ALYREF", "ANAPC1", "ANP32A", "ANP32B", "ANP32E", "AP1B1", "AP1G1", "AP1M1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "APEH", "APOL2", "APP", "ARCN1", "ARFIP1", "ARFIP2", "ARHGDIA", "ARID3B", "ARIH1", "ARPC1A", "ARPC3", "ARPC4", "ARPC5", "ASAH1", "ASF1A", "ASNA1", "ASNS", "ATAD3A", "ATAD3B", "ATG7", "ATIC", "ATL2", "ATP1A1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1D", "ATP6V1H", "ATPAF1", "ATPIF1", "ATXN2L", "AUP1", "AURKA", "BAG6", "BAIAP2", "BAK1", "BCAP31", "BCAS2", "BCLAF1", "BLMH", "BLVRA", "BLVRB", "BOP1", "BPNT1", "BRD4", "BRIX1", "BUB1", "BUB1B", "BUB3", "BUD31", "BZW1", "BZW2", "CACYBP", "CAD", "CALM3", "CALR", "CALU", "CAMK2G", "CAND1", "CANX", "CAP1", "CAPN1", "CAPRIN1", "CAPZA1", "CAPZB", "CARHSP1", "CARM1", "CARS", "CARS2", "CASK", "CASP3", "CASP6", "CASP7", "CASP8", "CBX1", "CBX3", "CBX5", "CCAR1", "CCAR2", "CCNB1", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2BP2", "CDC37", "CDC40", "CDC42", "CDC45", "CDK1", "CDK12", "CDK2", "CDK4", "CDK6", "CDKN2AIP", "CDX2", "CEBPZ", "CETN2", "CFAP20", "CHAF1B", "CHEK2", "CHERP", "CHKA", "CHML", "CHMP5", "CHMP6", "CHMP7", "CHORDC1", "CHRAC1", "CHST14", "CIRBP", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLCC1", "CLCN3", "CLGN", "CLIC1", "CLIC4", "CLNS1A", "CLPTM1", "CLPTM1L", "CLPX", "CLTA", "CLTC", "CLUH", "CMPK1", "CMSS1", "CNDP2", "CNN2", "CNN3", "CNOT1", "CNOT7", "CNP", "COASY", "COIL", "COLEC12", "COLGALT1", "COMT", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS3", "COPS5", "COPS6", "COPS8", "COPZ1", "CORO1B", "CORO1C", "COTL1", "COX2", "COX5A", "COX5B", "COX7A2", "COX7C", "CPOX", "CPSF1", "CPSF3", "CPSF6", "CPSF7", "CPT1A", "CPT2", "CPVL", "CRMP1", "CRNKL1", "CRTAP", "CS", "CSE1L", "CSK", "CSNK1A1", "CSNK2A2", "CSNK2B", "CSTB", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTNNA1", "CTNND1", "CTPS1", "CTPS2", "CTSA", "CTSC", "CTTN", "CUL1", "CUL2", "CUL4A", "CUL4B", "CUL5", "CYB5B", "CYB5D2", "CYFIP1", "CYP51A1", "DAD1", "DAP3", "DARS", "DARS2", "DBN1", "DBNL", "DCAF13", "DCP1A", "DCPS", "DCTD", "DCTN1", "DCTN2", "DCTN6", "DDAH1", "DDB1", "DDI2", "DDOST", "DDT", "DENR", "DERL1", "DHCR24", "DHCR7", "DHFR", "DHX15", "DHX37", "DHX38", "DHX8", "DHX9", "DICER1", "DIDO1", "DIEXF", "DIS3", "DLD", "DLST", "DNM1L", "DNM2", "DNMT1", "DOCK7", "DOLPP1", "DPF2", "DPH5", "DPP3", "DPP9", "DPYSL2", "DPYSL3", "DSG2", "DSP", "DST", "DTYMK", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNLL1", "DYNLL2", "EARS2", "EBP", "ECE1", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "EDC4", "EEA1", "EEF1A2", "EEF1B2", "EEF1D", "EEF2", "EEFSEC", "EFL1", "EFTUD2", "EHD1", "EHD4", "EIF2A", "EIF2AK2", "EIF2D", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3H", "EIF3I", "EIF3J", "EIF3L", "EIF4B", "EIF4E", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELOB", "ELOC", "ELP1", "ELP3", "EMC2", "EMG1", "ENO1", "EPHX2", "EPPK1", "EPRS", "EPS15", "EPS15L1", "ERAL1", "ERAP1", "ERH", "ERMP1", "ERO1A", "ERP29", "ESD", "ETF1", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXO1", "EXOC1", "EXOC4", "EXOC5", "EXOC7", "EXOSC3", "EXOSC4", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC8", "EZR", "FAHD1", "FARSB", "FASN", "FBL", "FDPS", "FDXR", "FECH", "FEN1", "FH", "FKBP1A", "FKBP4", "FKBP5", "FMR1", "FN3KRP", "FNTB", "FOXC1", "FOXRED1", "FSCN1", "FUBP1", "FUBP3", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GALK1", "GALNT2", "GALNT7", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GATAD2B", "GATB", "GBE1", "GCAT", "GCLM", "GCN1", "GDI1", "GDI2", "GFPT1", "GGH", "GINS2", "GLB1", "GLDC", "GLRX3", "GLRX5", "GLS", "GLUD1", "GLYR1", "GM2A", "GMDS", "GMFB", "GMPS", "GNA13", "GNAI1", "GNAI2", "GNAI3", "GNPDA1", "GNS", "GPATCH4", "GPD2", "GPI", "GPKOW", "GPR107", "GPR89B", "GPT2", "GPX8", "GRHPR", "GRPEL1", "GRSF1", "GSK3A", "GSK3B", "GSPT1", "GSR", "GSS", "GTF2B", "GTF2F1", "GTF2F2", "GTF3C3", "GTPBP1", "GYG1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HADHA", "HADHB", "HAT1", "HBS1L", "HCCS", "HDAC2", "HDGF", "HDGFL2", "HDHD2", "HDHD5", "HEATR1", "HEATR6", "HEXA", "HEXB", "HIBADH", "HIBCH", "HINT2", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLCS", "HM13", "HMBS", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMGCL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPM", "HNRNPR", "HOOK3", "HPRT1", "HSD17B10", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPE1", "HTATSF1", "HUWE1", "IARS", "IARS2", "IDE", "IDH3A", "IDH3B", "IDI1", "IGBP1", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IK", "ILF3", "ILK", "ILKAP", "ILVBL", "IMP3", "IMPDH1", "IMPDH2", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "ITCH", "ITGB1", "ITPA", "IVD", "KARS", "KAT7", "KCTD12", "KDELR1", "KDM1A", "KDM1B", "KDM3B", "KHDRBS1", "KHDRBS3", "KHSRP", "KIF11", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF3A", "KIF4A", "KIF5B", "KIFC1", "KPNA1", "KPNA2", "KPNA3", "KPNA6", "KPNB1", "KYAT3", "L2HGDH", "LAMP1", "LAMP2", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS2", "LBR", "LDHA", "LDHB", "LETM1", "LGALS3", "LGMN", "LIG1", "LIG3", "LIMA1", "LIPA", "LLGL1", "LMAN1", "LMAN2", "LNPEP", "LONP1", "LPCAT1", "LPP", "LRRC47", "LSM6", "LSM7", "LSM8", "M6PR", "MACF1", "MAGED2", "MAGT1", "MAP1B", "MAP1S", "MAP2K1", "MAP2K2", "MAP2K3", "MAPK1", "MAPK14", "MAPRE1", "MAPRE2", "MARS2", "MASTL", "MAT2A", "MBNL1", "MBOAT7", "MCCC1", "MCCC2", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCTS1", "MCU", "MDH1", "MDH2", "ME2", "MECP2", "METAP1", "MFAP1", "MFN1", "MFN2", "MFSD5", "MGST2", "MGST3", "MIA2", "MIA3", "MICU1", "MICU2", "MIPEP", "MMS19", "MORF4L1", "MPHOSPH10", "MPI", "MPP1", "MPP2", "MPP6", "MPRIP", "MPST", "MPV17L2", "MRPL1", "MRPL11", "MRPL12", "MRPL14", "MRPL17", "MRPL19", "MRPL20", "MRPL21", "MRPL38", "MRPL39", "MRPL43", "MRPL44", "MRPL47", "MRPL48", "MRPL49", "MRPL9", "MRPS2", "MRPS27", "MRPS35", "MRPS5", "MRPS7", "MSH2", "MSH3", "MSH6", "MSMO1", "MSN", "MTA1", "MTA2", "MTAP", "MTCH1", "MTCH2", "MTHFD1", "MTHFD1L", "MTHFD2", "MTOR", "MTPAP", "MUT", "MYBBP1A", "MYCBP", "MYEF2", "MYL6", "MYO1B", "MYO1D", "MYO6", "NAA10", "NAA15", "NAA25", "NAA35", "NAA50", "NADK2", "NAE1", "NAGK", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NARS", "NBN", "NCAPD2", "NCBP1", "NCBP2", "NCL", "NCOA5", "NDRG3", "NDUFA10", "NDUFA13", "NDUFA2", "NDUFA4", "NDUFA5", "NDUFA8", "NDUFA9", "NDUFB11", "NDUFB4", "NDUFB5", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS7", "NDUFS8", "NEK9", "NFKB1", "NFS1", "NHP2", "NISCH", "NKRF", "NLN", "NME1", "NME2", "NMT1", "NNT", "NOC4L", "NOL6", "NONO", "NOP10", "NOP14", "NOP56", "NOP58", "NOP9", "NPEPPS", "NPM1", "NRBP1", "NRDC", "NSD2", "NSDHL", "NSF", "NSFL1C", "NSUN2", "NT5C2", "NT5C3B", "NT5DC1", "NT5DC2", "NTMT1", "NTPCR", "NUCB1", "NUCB2", "NUDC", "NUDCD2", "NUDT1", "NUDT21", "NUDT5", "NUDT9", "NUP107", "NUP153", "NUP160", "NUP210", "NUP214", "NUP37", "NUP54", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NXF1", "OAT", "OCIAD1", "OCLN", "OLA1", "OPA1", "OSGEP", "OTUB1", "OXA1L", "P3H1", "P3H4", "PACSIN2", "PACSIN3", "PAICS", "PAK1", "PAK2", "PANK4", "PAPSS1", "PARK7", "PARN", "PASK", "PBK", "PBRM1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCK2", "PCMT1", "PCNA", "PDCD11", "PDCD4", "PDCD5", "PDCD6IP", "PDE12", "PDE6D", "PDK3", "PDLIM1", "PDLIM5", "PDLIM7", "PDS5A", "PDS5B", "PDXK", "PEBP1", "PECR", "PELO", "PEPD", "PES1", "PEX14", "PEX19", "PEX5", "PFDN2", "PFDN5", "PFKL", "PFKM", "PFKP", "PGD", "PGK1", "PGLS", "PGP", "PGRMC1", "PGRMC2", "PHF6", "PHGDH", "PI4K2A", "PI4KB", "PICALM", "PIGK", "PIK3C3", "PINX1", "PIP4K2C", "PIR", "PITPNA", "PITPNB", "PITRM1", "PKM", "PKMYT1", "PKN1", "PKN2", "PLA2G15", "PLAA", "PLBD2", "PLCG1", "PLD6", "PLEC", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLS3", "PM20D2", "PMPCA", "PMPCB", "PNP", "PNPT1", "POGZ", "POLA2", "POLDIP3", "POLE4", "POLR1A", "POLR1B", "POLR1C", "POLR2A", "POLR2B", "POLR2C", "POLR2E", "POLR2G", "POLR2L", "POLR3A", "POLRMT", "PPA1", "PPA2", "PPAT", "PPIL1", "PPM1G", "PPME1", "PPP1CA", "PPP1CB", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPT1", "PPT2", "PQBP1", "PRC1", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX6", "PREB", "PREP", "PRIM1", "PRKACA", "PRKAG1", "PRKCSH", "PRKDC", "PRKRA", "PRMT1", "PRMT3", "PRMT5", "PRPF3", "PRPF31", "PRPF39", "PRPF4", "PRPF4B", "PRPF6", "PRPF8", "PRPS2", "PRPSAP1", "PRPSAP2", "PRRC2A", "PRRC2C", "PSIP1", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD7", "PSMD8", "PSMF1", "PSPC1", "PTCD1", "PTDSS1", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK7", "PTPA", "PUM1", "PURA", "PWP1", "PXMP2", "PYGB", "PYGL", "QARS", "QDPR", "QKI", "QRSL1", "RAB3GAP2", "RABGAP1", "RAC1", "RAD23A", "RAD23B", "RAD9A", "RAE1", "RALA", "RALB", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP9", "RANGAP1", "RAPGEF2", "RAVER1", "RBBP6", "RBM12", "RBM12B", "RBM14", "RBM17", "RBM19", "RBM22", "RBM26", "RBM27", "RBM3", "RBM4", "RBM4B", "RBMX", "RBMXL1", "RBPMS", "RCL1", "RCN1", "RCN2", "RDH11", "RDH14", "RDX", "RECQL", "REEP5", "REPS1", "RFC2", "RFC3", "RFC4", "RFC5", "RFX1", "RHEB", "RHOA", "RHOG", "RHOT1", "RIPK1", "RNASEH2A", "RNF14", "RNH1", "RNPS1", "ROCK2", "RP2", "RPA1", "RPF2", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL18", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL38", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPN1", "RPN2", "RPP30", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RRM1", "RRM2", "RRS1", "RSF1", "RSL1D1", "S100A10", "S100A11", "S100A13", "SAE1", "SAP18", "SARS", "SARS2", "SART1", "SART3", "SBDS", "SC5D", "SCAF4", "SCAMP1", "SCAMP2", "SCAMP3", "SCARB1", "SCARB2", "SCFD1", "SCML2", "SCO1", "SCO2", "SCPEP1", "SDF4", "SDHA", "SDHB", "SEC11A", "SEC23A", "SEC23B", "SEC23IP", "SEC24A", "SEC24B", "SEC24C", "SEC31A", "SEC61A1", "SEC63", "SEH1L", "SENP3", "SEPHS1", "SEPT11", "SEPT2", "SEPT7", "SEPT9", "SERBP1", "SERPINB6", "SERPINH1", "SET", "SETD2", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B3", "SFPQ", "SFSWAP", "SFXN1", "SHMT1", "SHMT2", "SIRT1", "SKP1", "SLC16A1", "SLC19A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A17", "SLC25A20", "SLC25A22", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A33", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A4", "SLC29A1", "SLC2A1", "SLC33A1", "SLC35B2", "SLC35F2", "SLC3A2", "SLC7A1", "SLK", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCC1", "SMARCC2", "SMN1*", "SMYD3", "SNAP23", "SNAP29", "SND1", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNU13", "SNW1", "SNX1", "SNX2", "SOAT1", "SOD2", "SORD", "SORT1", "SPAG9", "SPCS2", "SPPL2A", "SPTLC1", "SPTLC2", "SQLE", "SREK1", "SRM", "SRP14", "SRP54", "SRP68", "SRP9", "SRPK1", "SRPRA", "SRRM1", "SRSF1", "SRSF10", "SRSF11", "SRSF3", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSR1", "STAG1", "STAG2", "STAMBP", "STAT1", "STAT3", "STK4", "STOM", "STOML2", "STRBP", "STT3A", "STX12", "STX18", "STX5", "STX7", "STXBP3", "SUCLA2", "SUCLG2", "SUGP1", "SUGP2", "SUN1", "SUPT16H", "SUPT6H", "SURF4", "SURF6", "SUZ12", "SV2A", "SYNCRIP", "SYNGR2", "SYNJ2BP", "TAF15", "TAGLN2", "TARS", "TARS2", "TBC1D10B", "TBC1D13", "TBC1D15", "TBC1D4", "TBC1D9B", "TBCA", "TBCC", "TBCD", "TBCE", "TCEA1", "TCERG1", "TCP1", "TDRKH", "TECR", "TFCP2", "TFRC", "THOC1", "THOC2", "THOC3", "THOP1", "THRAP3", "TJP1", "TK1", "TKT", "TM9SF3", "TMED10", "TMED2", "TMED5", "TMED7", "TMED9", "TMEM165", "TMEM97", "TMOD1", "TMOD3", "TMPO", "TNPO1", "TNPO2", "TNPO3", "TOE1", "TOMM20", "TOMM40", "TOP1", "TP53", "TP53BP1", "TPI1", "TPM1", "TPM3", "TPM4", "TPP1", "TPP2", "TPT1", "TPX2", "TRA2A", "TRA2B", "TRAP1", "TROVE2", "TSFM", "TSG101", "TTYH3", "TUBB", "TUBB2A", "TUBB2B", "TUBB4A", "TUBB4B", "TUBB6", "TUBGCP2", "TUBGCP3", "TUFM", "TWF1", "TWF2", "TXLNA", "TXLNG", "TXNDC12", "TXNDC17", "TXNRD1", "TYMS", "U2AF1", "U2SURP", "UBA1", "UBA2", "UBA3", "UBA6", "UBE2L3", "UBE4B", "UCHL5", "UGGT1", "UNC119", "UNC119B", "UPF1", "UQCR10", "UQCRB", "UQCRC1", "UQCRC2", "USO1", "USP10", "USP11", "USP14", "USP15", "USP39", "USP47", "USP5", "USP7", "UTP11", "UTP14A", "UTP3", "UTP6", "VAMP7", "VAPA", "VAPB", "VBP1", "VKORC1L1", "VMP1", "VPS18", "VPS26A", "VPS29", "VPS33A", "VPS33B", "VPS35", "VPS4B", "VPS52", "VRK1", "VTI1B", "WARS", "WDHD1", "WDR1", "WDR82", "WIZ", "WNK1", "XAB2", "XPO1", "XPO5", "XPO7", "XPOT", "XRCC5", "XRCC6", "YARS", "YARS2", "YEATS4", "YLPM1", "YME1L1", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2", "ZC3H11A", "ZC3H15", "ZC3H7A", "ZCCHC8", "ZFR", "ZMPSTE24", "ZMYM2", "ZNF207", "ZNF281", "ZNF622", "ZW10", "ZYX"], "leading_proteins": ["ABCB1", "ABCB7", "ABCD3", "ACAD9", "ACOT8", "ACOX1", "ACOX3", "ADK", "ADPGK", "AKT2", "ALG1", "APOL2", "ASNA1", "ATP2A2", "ATP6V0A1", "ATP6V0A2", "AUP1", "BCAP31", "BLVRB", "BUB1", "CALU", "CAMK2G", "CARM1", "CASK", "CBX3", "CBX5", "CDK4", "CHKA", "CLCC1", "CLCN3", "CLUH", "COPB2", "COPS6", "COX7A2", "CPOX", "CPT2", "CSNK1A1", "CTSC", "CYB5B", "CYB5D2", "CYP51A1", "DERL1", "DHCR24", "DHCR7", "DPP9", "ECE1", "ERMP1", "EWSR1", "FDPS", "FNTB", "FUBP1", "FUBP3", "FUS", "GALNT2", "GALNT7", "GLUD1", "GPD2", "GPX8", "GSK3A", "GYG1", "HDAC2", "HM13", "HNRNPK", "IPO4", "KDELR1", "KDM1A", "KDM3B", "KHDRBS1", "KHDRBS3", "KHSRP", "KYAT3", "LBR", "LETM1", "LNPEP", "MAGED2", "MAP2K2", "MAPK1", "MBOAT7", "METAP1", "MFAP1", "MFN1", "MIA2", "MPV17L2", "MSMO1", "MTCH1", "MTCH2", "NAMPT", "NAP1L4", "NDUFB4", "NDUFB9", "NDUFS2", "NNT", "NONO", "NPEPPS", "NRDC", "NT5C3B", "NUCB1", "NUP37", "NUP93", "OXA1L", "P3H1", "P3H4", "PAK1", "PARN", "PASK", "PDK3", "PECR", "PEX14", "PEX5", "PGRMC1", "PGRMC2", "PIK3C3", "PIP4K2C", "PITRM1", "PKM", "PKMYT1", "PLA2G15", "PLBD2", "PMPCA", "PPT1", "PPT2", "PRCP", "PTGES2", "PTPA", "PXMP2", "RAVER1", "RBM14", "RBM3", "RBM4", "RBM4B", "RBMX", "RBPMS", "RCN2", "REEP5", "RIPK1", "RNPS1", "RRM2", "SCARB1", "SCARB2", "SDF4", "SDHB", "SEC11A", "SEC24B", "SET", "SF1", "SFPQ", "SFXN1", "SIRT1", "SLC16A1", "SLC19A1", "SLC25A10", "SLC25A11", "SLC25A13", "SLC25A15", "SLC25A20", "SLC25A26", "SLC25A32", "SLC25A33", "SLC25A6", "SLC2A1", "SLC35B2", "SLC35F2", "SLC3A2", "SLC7A1", "SOAT1", "SORT1", "SQLE", "SRSF1", "SRSF3", "SRSF9", "SSR1", "STT3A", "STX18", "STX5", "STX7", "SV2A", "SYNGR2", "TAF15", "TM9SF3", "TMEM165", "TMEM97", "TOMM40", "TRA2A", "TRA2B", "UNC119", "UNC119B", "UQCR10", "VAMP7", "VKORC1L1", "VPS33B", "VTI1B", "ZADH2", "ZMPSTE24"]} \ No newline at end of file diff --git a/pharos_protein_category/advanced/idx2term.json b/pharos_protein_category/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..5caa491b9aa6e04692523f9ba93639712ee5eb71 --- /dev/null +++ b/pharos_protein_category/advanced/idx2term.json @@ -0,0 +1 @@ +{"0": "Tdark"} \ No newline at end of file diff --git a/pharos_protein_category/advanced/plot_0.png b/pharos_protein_category/advanced/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..343f25ee459563880b498163c9dd0af60dfaa0f6 --- /dev/null +++ b/pharos_protein_category/advanced/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:0ee101e88bb0a8a4bbf73aaf4353bd3b9c00421261903b169d426aed793ba31a +size 203206 diff --git a/pharos_protein_category/basic/idx2term.json b/pharos_protein_category/basic/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..c17f34effbf11642a3899eeac3248995116572b2 --- /dev/null +++ b/pharos_protein_category/basic/idx2term.json @@ -0,0 +1 @@ +{"0": "Tdark", "1": "Tchem", "2": "Tclin"} \ No newline at end of file diff --git a/pharos_protein_category/basic/plot_0.png b/pharos_protein_category/basic/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..4b64fc79448711008343ea1bfd7b3681f899438f --- /dev/null +++ b/pharos_protein_category/basic/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:4da33178733b0ccedc004a1c4bb61c79c3fc7cfff55bef3045dda7809b56ed5d +size 132962 diff --git a/pharos_protein_category/basic/plot_1.png b/pharos_protein_category/basic/plot_1.png new file mode 100644 index 0000000000000000000000000000000000000000..3a551aa7a6a93cfdd3fe26d85545c6e9b9606361 --- /dev/null +++ b/pharos_protein_category/basic/plot_1.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:0b039ad7ec0666bf20e8f50f381b1df3eb211fb252f436c323f3d93c0e00da16 +size 133754 diff --git a/pharos_protein_category/basic/plot_2.png b/pharos_protein_category/basic/plot_2.png new file mode 100644 index 0000000000000000000000000000000000000000..b941cb5c7e639d5e017e6cd27d22ae9905dce6c0 --- /dev/null +++ b/pharos_protein_category/basic/plot_2.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:1fb23acdb73e1cd275201ba0b800687c8863c936f36903e6a401100165568659 +size 138577 diff --git a/pharos_protein_category/consensus.joblib b/pharos_protein_category/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..c844c95df7132aed00b4bf55079c66b8bf4ea952 --- /dev/null +++ b/pharos_protein_category/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:45a303bab8cfaf3d2a7ece4d5ac15458c08c0b0b0f7555edef6ff444e9741e36 +size 61715 diff --git a/pharos_protein_category/df_merge.tsv b/pharos_protein_category/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..ce4f4760c47ce1d8cc8c1b631f44376792e7f689 --- /dev/null +++ b/pharos_protein_category/df_merge.tsv @@ -0,0 +1,2 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Tdark 79 256 2.464048846852638 0.0137377388008912 74.3131067961165 324.373786407767 0.5859664552431031 0.6577158703271868 20.515717939687796 49.369088361677456 1.229854636263473 0.4013924214985833 0.9914418886409976 0.898371226935302 0.9285710330616797 0.9986612100784809 0.9999998092878924 diff --git a/pharos_protein_category/metrics.json b/pharos_protein_category/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..4e022f4fcf0da73f19ae0cd30e138e1d2755e81a --- /dev/null +++ b/pharos_protein_category/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2734, + "annotations_size": 4, + "title": "Average number of proteins per term", + "value": 683.25 +} \ No newline at end of file diff --git a/pharos_protein_category/paths.json b/pharos_protein_category/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..07b075f4a9c9be65b1431e3c4699360d19916dc5 --- /dev/null +++ b/pharos_protein_category/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/pharos_protein_category/fragment/C166/C166_val_log2fc"} \ No newline at end of file diff --git a/pharos_protein_category/result.tsv b/pharos_protein_category/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..ca832227f450ce759c0b2dd6435a9c1141aa2b06 --- /dev/null +++ b/pharos_protein_category/result.tsv @@ -0,0 +1,4 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Tdark 0.3467632776666922 2.464048846852638 0.0137377388008912 0.0538289374267966 0.0549509552035649 256 Q969T7,O60830,Q8IYR2,O00193,Q9P260,Q9H1E5,Q9NX00,Q5VW38,Q9NPR9,Q9BQ04,Q8N6R0,Q6UW68,Q8NBN7,Q9HD45,Q3SXM5,Q96FJ2,Q9H9B4,Q66K14,Q8WUJ1,O75964,Q9HD20,Q8N4H5,Q9Y3B3,Q9Y305,Q6UW02,Q9NVZ3,Q69YU5,Q8ND83,Q8WUA4,Q9Y6I9,Q9NRY5,Q5R3I4,Q8IXU6,Q8IYS2,Q9NR77,Q7Z2K6,Q9H4I3,Q5SNT2,Q15629,Q8NE00,Q9ULJ7,Q9BSH5,Q92564,Q9Y5M8,Q7Z6M1,Q9BSJ2,Q9NU23,A0AVF1,P14406,P84157,Q9BTE7,Q96SK2,Q70UQ0,P82933,Q8WWC4,Q96DB5,Q9NYK5,O43615,Q8NFH4,Q9BWH2,O15126,Q15005,O75935,Q9Y3E0,Q9BYC9,P49750,Q6NUQ4,O94919,Q1KMD3,Q96IX5,Q9H857,Q86YN1,Q5JVF3,Q52LJ0,Q8WVC6,Q5T3I0,Q9BXW7,Q9Y320,Q8N8A6 79 +Tchem 0.3021835469141771 1.3922996473137188 0.1638316782811011 0.5111508762869637 0.3276633565622022 287 P09960,Q8NEB9,Q16850,P37268,O60725,P23786,P62993,P45880,Q02818,Q9H773,P08236,P41440,O43865,P55786,Q13546,Q8WTV0,P11166,P35790,O95470,Q9UIQ6,P55263,Q13432,P42892,P09601,Q9NZ45,P05067,O14936,P07099,P53582,Q86TI2,Q14534,Q15125,P53634,O60502,Q15120,Q96K76,Q8NCG7,P30519,P04062,P31751,P08183,Q13555,P42785,Q13126,Q9UBM7,Q5BJF2,Q5JRX3,P49356,P48449,P14618,P06737,O00767,Q9H7Z7 53 +Tclin 0.2969552692389765 0.7348436558509687 0.4624347163359341 0.9164926204765748 0.6165796217812455 82 O95168,P11802,O75306,O96000,O43924,Q9Y6M9,O43674,P49840,Q9NX14,P21964,P14324,P05023,P36507,P00813,P38435,Q06203,Q86Y39,Q7L0J3,Q99720,P49721,Q9P0J0,P62942,O43676,P20618,P31350 25 diff --git a/pharos_protein_category/selections.json b/pharos_protein_category/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..c53d69b427df409baca9e2193f976a413bd78b5c --- /dev/null +++ b/pharos_protein_category/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["Tbio", "Tchem", "Tclin", "Tdark"], "available_proteins": ["AAAS", "AAR2", "AARS", "AARS2", "AARSD1", "AASDHPPT", "AASS", "AATF", "ABCB1", "ABCB10", "ABCB7", "ABCD3", "ABCE1", "ABCF1", "ABCF2", "ABHD10", "ABHD12", "ABHD14B", "ABHD6", "ACAA2", "ACACA", "ACACB", "ACAD9", "ACADM", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACBD5", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT8", "ACOT9", "ACOX1", "ACOX3", "ACP1", "ACP2", "ACP6", "ACSL1", "ACSL3", "ACSL4", "ACTN1", "ACTN2", "ACTN4", "ACTR10", "ACTR1A", "ACTR2", "ACTR3", "ADA", "ADAR", "ADD1", "ADD3", "ADH5", "ADI1", "ADK", "ADNP", "ADPGK", "ADPRHL2", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGK", "AGL", "AGPAT1", "AGPS", "AHCTF1", "AHCY", "AHCYL1", "AHNAK", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AK4", "AK6", "AKAP12", "AKAP13", "AKAP8", "AKAP8L", "AKR1A1", "AKR1B1", "AKR7A2", "AKT2", "ALDH18A1", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALG1", "ALKBH5", "ALYREF", "AMOT", "ANAPC1", "ANAPC16", "ANAPC4", "ANAPC5", "ANAPC7", "ANK3", "ANKFY1", "ANKHD1", "ANKLE2", "ANKRD50", "ANLN", "ANP32A", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP1M1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "APC", "APEH", "APEX1", "API5", "APMAP", "APOL2", "APOOL", "APP", "APPL1", "APRT", "AQR", "ARCN1", "ARF4", "ARF5", "ARFGAP1", "ARFIP1", "ARFIP2", "ARHGAP17", "ARHGDIA", "ARHGEF1", "ARHGEF2", "ARID1A", "ARID3B", "ARIH1", "ARL1", "ARL2", "ARL3", "ARL6IP1", "ARL6IP5", "ARL8B", "ARMC1", "ARMC6", "ARMC8", "ARMCX3", "ARMT1", "ARPC1A", "ARPC2", "ARPC3", "ARPC4", "ARPC5", "ASAH1", "ASCC3", "ASF1A", "ASNA1", "ASNS", "ASPH", "ATAD1", "ATAD3A", "ATAD3B", "ATAD5", "ATE1", "ATG7", "ATIC", "ATL2", "ATP13A1", "ATP1A1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5L", "ATP5O", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1D", "ATP6V1E1", "ATP6V1H", "ATPAF1", "ATPIF1", "ATXN10", "ATXN2L", "AUP1", "AURKA", "B3GALT6", "B4GAT1", "BABAM1", "BAG2", "BAG4", "BAG5", "BAG6", "BAIAP2", "BAK1", "BANF1", "BAP18", "BASP1", "BAZ1A", "BAZ1B", "BCAP31", "BCAS2", "BCAS3", "BCCIP", "BCL2L13", "BCLAF1", "BCS1L", "BDH2", "BICD2", "BIRC6", "BLMH", "BLVRA", "BLVRB", "BMS1", "BNIP1", "BOP1", "BPNT1", "BPTF", "BRAT1", "BRD4", "BRI3BP", "BRIX1", "BSG", "BTAF1", "BTF3", "BUB1", "BUB1B", "BUB3", "BUD31", "BYSL", "BZW1", "BZW2", "C11orf58", "C12orf43", "C12orf73", "C19orf70", "C1QBP", "C1orf122", "C1orf35", "CACYBP", "CAD", "CALD1", "CALM3", "CALR", "CALU", "CAMK2G", "CAND1", "CANX", "CAP1", "CAPN1", "CAPNS1", "CAPRIN1", "CAPZA1", "CAPZB", "CARHSP1", "CARM1", "CARS", "CARS2", "CASK", "CASP3", "CASP6", "CASP7", "CASP8", "CAST", "CBR1", "CBX1", "CBX3", "CBX5", "CBX8", "CCAR1", "CCAR2", "CCDC124", "CCDC134", "CCDC137", "CCDC138", "CCDC22", "CCDC47", "CCDC6", "CCDC86", "CCDC93", "CCDC94", "CCNB1", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2AP", "CD2BP2", "CD3EAP", "CD47", "CDC123", "CDC16", "CDC23", "CDC27", "CDC37", "CDC40", "CDC42", "CDC45", "CDC5L", "CDC73", "CDCA5", "CDIPT", "CDK1", "CDK12", "CDK2", "CDK4", "CDK5RAP3", "CDK6", "CDKN2AIP", "CDS2", "CDV3", "CDX2", "CEBPZ", "CELF1", "CENPV", "CEP44", "CEP55", "CERS1", "CERS2", "CETN2", "CFAP20", "CFL1", "CFL2", "CGGBP1", "CHAC2", "CHAF1B", "CHAMP1", "CHCHD3", "CHD1", "CHD4", "CHEK2", "CHERP", "CHID1", "CHKA", "CHML", "CHMP1A", "CHMP2B", "CHMP5", "CHMP6", "CHMP7", "CHORDC1", "CHRAC1", "CHST14", "CIAPIN1", "CIP2A", "CIRBP", "CISD1", "CISD2", "CIZ1", "CKAP2", "CKAP4", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLCC1", "CLCN3", "CLGN", "CLIC1", "CLIC4", "CLINT1", "CLN5", "CLNS1A", "CLPB", "CLPP", "CLPTM1", "CLPTM1L", "CLPX", "CLTA", "CLTC", "CLUH", "CMPK1", "CMSS1", "CNDP2", "CNN2", "CNN3", "CNNM3", "CNNM4", "CNOT1", "CNOT7", "CNOT9", "CNP", "CNPY2", "COA3", "COA7", "COASY", "COG2", "COG6", "COIL", "COLEC12", "COLGALT1", "COMMD4", "COMT", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS7A", "COPS7B", "COPS8", "COPZ1", "COQ8A", "COQ9", "CORO1B", "CORO1C", "COTL1", "COX15", "COX4I1", "COX5A", "COX5B", "COX6C", "COX7A2", "COX7C", "CPD", "CPNE1", "CPNE3", "CPOX", "CPPED1", "CPSF1", "CPSF2", "CPSF3", "CPSF6", "CPSF7", "CPT1A", "CPT2", "CPVL", "CRKL", "CRMP1", "CRNKL1", "CRTAP", "CRYZ", "CS", "CSDE1", "CSE1L", "CSK", "CSNK1A1", "CSNK2A2", "CSNK2B", "CSTB", "CSTF1", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTDSPL2", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTPS2", "CTR9", "CTSA", "CTSC", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4A", "CUL4B", "CUL5", "CUTA", "CWF19L1", "CXorf57", "CYB5B", "CYB5D2", "CYB5R3", "CYC1", "CYFIP1", "CYP20A1", "CYP51A1", "DAD1", "DAGLB", "DAP3", "DARS", "DARS2", "DAZAP1", "DBN1", "DBNL", "DCAF1", "DCAF13", "DCAF7", "DCAKD", "DCD", "DCP1A", "DCPS", "DCTD", "DCTN1", "DCTN2", "DCTN3", "DCTN4", "DCTN6", "DCTPP1", "DCUN1D4", "DCUN1D5", "DCXR", "DDAH1", "DDB1", "DDI2", "DDOST", "DDRGK1", "DDT", "DDX1", "DDX10", "DDX17", "DDX18", "DDX20", "DDX21", "DDX23", "DDX24", "DDX27", "DDX28", "DDX39A", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX50", "DDX51", "DDX52", "DDX54", "DDX55", "DDX56", "DDX6", "DEK", "DENR", "DERL1", "DFFA", "DHCR24", "DHCR7", "DHFR", "DHPS", "DHRS7B", "DHX15", "DHX16", "DHX30", "DHX36", "DHX37", "DHX38", "DHX8", "DHX9", "DIABLO", "DIAPH1", "DIAPH3", "DICER1", "DIDO1", "DIEXF", "DIP2B", "DIS3", "DKC1", "DLAT", "DLD", "DLST", "DNAAF5", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC2", "DNAJC3", "DNAJC7", "DNAJC8", "DNAJC9", "DNM1L", "DNM2", "DNMT1", "DNPH1", "DNTTIP2", "DOCK7", "DOHH", "DOLPP1", "DPF2", "DPH2", "DPH5", "DPP3", "DPP9", "DPYSL2", "DPYSL3", "DRG1", "DRG2", "DSG2", "DSP", "DST", "DSTN", "DTL", "DTYMK", "DUSP3", "DUSP9", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNLL1", "DYNLL2", "EARS2", "EBNA1BP2", "EBP", "ECD", "ECE1", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "ECSIT", "EDC3", "EDC4", "EDF1", "EEA1", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EEFSEC", "EFL1", "EFTUD2", "EHD1", "EHD4", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2D", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAC2", "ELAVL1", "ELOB", "ELOC", "ELP1", "ELP2", "ELP3", "EMC1", "EMC2", "EMC3", "EMC4", "EMD", "EMG1", "EML4", "ENAH", "ENDOD1", "ENO1", "ENSA", "EPB41", "EPB41L2", "EPB41L3", "EPHX1", "EPHX2", "EPPK1", "EPRS", "EPS15", "EPS15L1", "ERAL1", "ERAP1", "ERCC2", "ERCC3", "ERGIC2", "ERGIC3", "ERH", "ERLIN1", "ERLIN2", "ERMP1", "ERO1A", "ERP29", "ERP44", "ESD", "ESF1", "ESYT1", "ESYT2", "ETF1", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXO1", "EXOC1", "EXOC2", "EXOC4", "EXOC5", "EXOC7", "EXOSC10", "EXOSC3", "EXOSC4", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC8", "EZR", "F11R", "FABP5", "FADS2", "FAF1", "FAF2", "FAH", "FAHD1", "FAM114A2", "FAM120A", "FAM162A", "FAM208A", "FAM213A", "FAM3C", "FAM49B", "FAM50A", "FAM8A1", "FAM91A1", "FAM98A", "FAM98B", "FANCI", "FAR1", "FARSA", "FARSB", "FASN", "FASTKD2", "FAU", "FBL", "FBXO22", "FBXO7", "FDFT1", "FDPS", "FDX1", "FDXR", "FECH", "FEN1", "FERMT2", "FGFR1OP", "FH", "FHL1", "FHOD1", "FIP1L1", "FIS1", "FKBP10", "FKBP14", "FKBP1A", "FKBP3", "FKBP4", "FKBP5", "FKBP7", "FKBP8", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FMR1", "FN3KRP", "FNDC3A", "FNTB", "FOXC1", "FOXRED1", "FRYL", "FSCN1", "FTO", "FTSJ1", "FTSJ3", "FUBP1", "FUBP3", "FUCA1", "FUCA2", "FUNDC2", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GADD45GIP1", "GALK1", "GALNT2", "GALNT7", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GATAD2B", "GATB", "GATC", "GBA", "GBE1", "GBF1", "GCAT", "GCC2", "GCDH", "GCLM", "GCN1", "GDAP1", "GDI1", "GDI2", "GDPD1", "GEMIN4", "GEMIN5", "GET4", "GFM1", "GFPT1", "GGA1", "GGCT", "GGCX", "GGH", "GHDC", "GHITM", "GIGYF2", "GINS2", "GINS3", "GINS4", "GLA", "GLB1", "GLDC", "GLG1", "GLMN", "GLO1", "GLOD4", "GLRX3", "GLRX5", "GLS", "GLUD1", "GLYR1", "GM2A", "GMDS", "GMFB", "GMPPA", "GMPPB", "GMPS", "GNA13", "GNAI1", "GNAI2", "GNAI3", "GNL1", "GNL2", "GNL3", "GNL3L", "GNPDA1", "GNS", "GOLGA3", "GOLGB1", "GOLIM4", "GOLPH3", "GOLT1B", "GORASP2", "GOT1", "GOT2", "GPAM", "GPATCH4", "GPATCH8", "GPD2", "GPHN", "GPI", "GPKOW", "GPR107", "GPR108", "GPR89B", "GPS1", "GPT2", "GPX8", "GRB2", "GRHPR", "GRPEL1", "GRSF1", "GRWD1", "GSK3A", "GSK3B", "GSPT1", "GSR", "GSS", "GSTK1", "GSTM3", "GSTO1", "GSTZ1", "GTF2B", "GTF2E1", "GTF2F1", "GTF2F2", "GTF2I", "GTF3C1", "GTF3C2", "GTF3C3", "GTPBP1", "GTPBP10", "GTPBP3", "GTPBP4", "GUSB", "GYG1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACD3", "HADH", "HADHA", "HADHB", "HAT1", "HAUS4", "HAUS5", "HBS1L", "HCCS", "HCFC1", "HDAC2", "HDGF", "HDGFL2", "HDHD2", "HDHD3", "HDHD5", "HDLBP", "HEATR1", "HEATR3", "HEATR6", "HEBP1", "HECTD1", "HELLS", "HEXA", "HEXB", "HGH1", "HGS", "HIBADH", "HIBCH", "HINT2", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HLTF", "HM13", "HMBS", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMGCL", "HMGCS1", "HMOX1", "HMOX2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HNRNPUL2", "HOOK3", "HP1BP3", "HPRT1", "HS2ST1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSDL1", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA14", "HSPA1B", "HSPA2", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPB1", "HSPBP1", "HSPD1", "HSPE1", "HSPH1", "HTATSF1", "HTT", "HUS1", "HUWE1", "HYOU1", "IARS", "IARS2", "IBA57", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDI1", "IFIT5", "IFT27", "IGBP1", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IK", "IKBIP", "ILF2", "ILF3", "ILK", "ILKAP", "ILVBL", "IMMT", "IMP3", "IMPDH1", "IMPDH2", "INA", "INF2", "INTS13", "INTS14", "INTS3", "INTS7", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IRGQ", "IRS4", "ISOC1", "IST1", "ISYNA1", "ITCH", "ITGB1", "ITPA", "IVD", "IWS1", "JPT2", "JUP", "KARS", "KAT7", "KCTD12", "KCTD5", "KDELC2", "KDELR1", "KDM1A", "KDM1B", "KDM2A", "KDM3B", "KDSR", "KHDRBS1", "KHDRBS3", "KHSRP", "KIAA0319L", "KIAA0368", "KIAA1468", "KIAA2013", "KIF11", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF3A", "KIF4A", "KIF5B", "KIFBP", "KIFC1", "KLC1", "KLC2", "KLC4", "KNOP1", "KPNA1", "KPNA2", "KPNA3", "KPNA6", "KPNB1", "KRI1", "KTN1", "KYAT3", "L1RE1", "L2HGDH", "LAMP1", "LAMP2", "LAMTOR1", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LAS1L", "LASP1", "LBR", "LDHA", "LDHB", "LDLR", "LEMD2", "LEMD3", "LENG8", "LETM1", "LGALS3", "LGALS3BP", "LGMN", "LIG1", "LIG3", "LIMA1", "LIPA", "LLGL1", "LMAN1", "LMAN2", "LMNA", "LMNB1", "LMNB2", "LNPEP", "LNPK", "LONP1", "LPCAT1", "LPP", "LRBA", "LRPAP1", "LRPPRC", "LRRC40", "LRRC47", "LRRC57", "LRRC59", "LSM12", "LSM6", "LSM7", "LSM8", "LSS", "LTA4H", "LTV1", "LUC7L2", "LYAR", "LYPLA1", "LYRM2", "LZIC", "LZTFL1", "M6PR", "MACF1", "MAD1L1", "MAD2L1", "MAGED2", "MAGT1", "MAIP1", "MAK16", "MAP1B", "MAP1S", "MAP2K1", "MAP2K2", "MAP2K3", "MAP4", "MAPK1", "MAPK14", "MAPRE1", "MAPRE2", "MARC1", "MARCKS", "MARS", "MARS2", "MASTL", "MAT2A", "MAT2B", "MATR3", "MAU2", "MAVS", "MBNL1", "MBOAT7", "MCAT", "MCCC1", "MCCC2", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCMBP", "MCTS1", "MCU", "MCUR1", "MDC1", "MDH1", "MDH2", "MDN1", "ME2", "MEAF6", "MECP2", "MED1", "MED24", "MESD", "METAP1", "METTL13", "MFAP1", "MFN1", "MFN2", "MFSD5", "MGEA5", "MGME1", "MGST2", "MGST3", "MIA2", "MIA3", "MICU1", "MICU2", "MID1", "MIF", "MIGA1", "MINPP1", "MIOS", "MIPEP", "MKI67", "MLEC", "MMAB", "MMS19", "MOGS", "MON2", "MORF4L1", "MOSPD2", "MOV10", "MPDU1", "MPHOSPH10", "MPI", "MPP1", "MPP2", "MPP6", "MPRIP", "MPST", "MPV17L2", "MRC2", "MRE11", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL14", "MRPL15", "MRPL17", "MRPL19", "MRPL20", "MRPL21", "MRPL37", "MRPL38", "MRPL39", "MRPL40", "MRPL43", "MRPL44", "MRPL45", "MRPL47", "MRPL48", "MRPL49", "MRPL50", "MRPL53", "MRPL58", "MRPL9", "MRPS15", "MRPS17", "MRPS2", "MRPS22", "MRPS23", "MRPS25", "MRPS27", "MRPS30", "MRPS31", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRPS9", "MRTO4", "MSH2", "MSH3", "MSH6", "MSI1", "MSMO1", "MSN", "MSTO1", "MTA1", "MTA2", "MTAP", "MTBP", "MTCH1", "MTCH2", "MTDH", "MTFP1", "MTHFD1", "MTHFD1L", "MTHFD2", "MTOR", "MTPAP", "MTPN", "MTR", "MTX1", "MTX2", "MUT", "MXRA7", "MYBBP1A", "MYCBP", "MYDGF", "MYEF2", "MYG1", "MYH10", "MYH14", "MYH9", "MYL6", "MYO1B", "MYO1D", "MYO6", "NAA10", "NAA15", "NAA25", "NAA35", "NAA40", "NAA50", "NADK2", "NAE1", "NAF1", "NAGK", "NAGLU", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NAPG", "NARS", "NASP", "NAT10", "NAXE", "NBN", "NCAPD2", "NCAPG", "NCAPH", "NCBP1", "NCBP2", "NCDN", "NCKAP1", "NCL", "NCLN", "NCOA5", "NCSTN", "NDC1", "NDRG3", "NDUFA10", "NDUFA11", "NDUFA13", "NDUFA2", "NDUFA4", "NDUFA5", "NDUFA7", "NDUFA8", "NDUFA9", "NDUFAF4", "NDUFAF7", "NDUFB10", "NDUFB11", "NDUFB3", "NDUFB4", "NDUFB5", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS7", "NDUFS8", "NDUFV1", "NDUFV2", "NECAP2", "NEFL", "NEFM", "NEK9", "NELFA", "NELFCD", "NELFE", "NEMF", "NENF", "NES", "NFKB1", "NFS1", "NHLRC2", "NHP2", "NIFK", "NIP7", "NIPSNAP2", "NISCH", "NKRF", "NKTR", "NLE1", "NLN", "NMD3", "NME1", "NME2", "NMT1", "NNT", "NOC2L", "NOC3L", "NOC4L", "NOL10", "NOL11", "NOL6", "NOL7", "NOL8", "NOL9", "NOLC1", "NONO", "NOP10", "NOP14", "NOP16", "NOP2", "NOP56", "NOP58", "NOP9", "NOSIP", "NPC1", "NPEPPS", "NPLOC4", "NPM1", "NRBP1", "NRDC", "NSA2", "NSD2", "NSDHL", "NSF", "NSFL1C", "NSUN2", "NSUN5", "NT5C2", "NT5C3B", "NT5DC1", "NT5DC2", "NTMT1", "NTPCR", "NUB1", "NUBP2", "NUBPL", "NUCB1", "NUCB2", "NUCKS1", "NUDC", "NUDCD1", "NUDCD2", "NUDT1", "NUDT21", "NUDT5", "NUDT9", "NUFIP2", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP160", "NUP188", "NUP205", "NUP210", "NUP214", "NUP35", "NUP37", "NUP50", "NUP54", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NUTF2", "NVL", "NXF1", "NXN", "OAT", "OCIAD1", "OCLN", "OGDH", "OGT", "OLA1", "OPA1", "OPA3", "OSBP", "OSBPL11", "OSBPL6", "OSBPL8", "OSBPL9", "OSGEP", "OTUB1", "OXA1L", "P3H1", "P3H4", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PACSIN3", "PAF1", "PAFAH1B1", "PAFAH1B3", "PAICS", "PAK1", "PAK1IP1", "PAK2", "PALLD", "PANK4", "PAPSS1", "PARK7", "PARN", "PARP1", "PARP2", "PASK", "PBDC1", "PBK", "PBRM1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCID2", "PCK2", "PCLAF", "PCM1", "PCMT1", "PCNA", "PCNP", "PCYOX1", "PDAP1", "PDCD11", "PDCD4", "PDCD5", "PDCD6", "PDCD6IP", "PDCL3", "PDE12", "PDE4DIP", "PDE6D", "PDHA1", "PDHB", "PDIA3", "PDIA4", "PDIA6", "PDK3", "PDLIM1", "PDLIM5", "PDLIM7", "PDS5A", "PDS5B", "PDXK", "PEBP1", "PECR", "PEF1", "PELO", "PELP1", "PEPD", "PES1", "PEX11G", "PEX14", "PEX19", "PEX5", "PFAS", "PFDN2", "PFDN4", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGP", "PGRMC1", "PGRMC2", "PHB", "PHB2", "PHF5A", "PHF6", "PHF8", "PHGDH", "PI4K2A", "PI4KB", "PICALM", "PIGK", "PIGS", "PIH1D1", "PIK3C3", "PIN1", "PIN4", "PINX1", "PIP4K2C", "PIR", "PISD", "PITHD1", "PITPNA", "PITPNB", "PITRM1", "PKM", "PKMYT1", "PKN1", "PKN2", "PLA2G15", "PLAA", "PLBD2", "PLCG1", "PLD3", "PLD6", "PLEC", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLRG1", "PLS3", "PM20D2", "PMPCA", "PMPCB", "PNN", "PNO1", "PNP", "PNPLA8", "PNPT1", "POFUT1", "POGZ", "POLA1", "POLA2", "POLD1", "POLDIP2", "POLDIP3", "POLE", "POLE3", "POLE4", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2A", "POLR2B", "POLR2C", "POLR2E", "POLR2G", "POLR2L", "POLR3A", "POLRMT", "PON2", "POP1", "POR", "PPA1", "PPA2", "PPAN", "PPAT", "PPFIA1", "PPIB", "PPID", "PPIE", "PPIF", "PPIH", "PPIL1", "PPIL4", "PPM1G", "PPME1", "PPOX", "PPP1CA", "PPP1CB", "PPP1R10", "PPP1R12A", "PPP1R7", "PPP1R8", 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"RIDA", "RIF1", "RINT1", "RIOX2", "RIPK1", "RMDN1", "RNASEH2A", "RNASET2", "RNF14", "RNF20", "RNF219", "RNF40", "RNH1", "RNPEP", "RNPS1", "ROCK2", "RP2", "RPA1", "RPA2", "RPAP1", "RPAP3", "RPF2", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPN1", "RPN2", "RPP30", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RRBP1", "RRM1", "RRM2", "RRP1", "RRP12", "RRP15", "RRP1B", "RRP8", "RRS1", "RSF1", "RSL1D1", "RSU1", "RTCB", "RTN2", "RTN3", "RTN4", "RTN4IP1", "RTRAF", "RUFY1", "RUVBL1", "RUVBL2", "S100A10", "S100A11", "S100A13", "SACM1L", "SAE1", "SAFB", "SAFB2", "SAMHD1", "SAMM50", "SAP130", "SAP18", "SAR1A", "SARNP", "SARS", "SARS2", "SART1", "SART3", "SBDS", "SC5D", "SCAF1", "SCAF4", "SCAMP1", "SCAMP2", "SCAMP3", "SCARB1", "SCARB2", "SCCPDH", "SCD", "SCFD1", "SCML2", "SCO1", "SCO2", "SCP2", "SCPEP1", "SCRIB", "SCRN1", "SDF4", "SDHA", "SDHB", "SEC11A", "SEC16A", "SEC22B", "SEC23A", "SEC23B", "SEC23IP", "SEC24A", "SEC24B", "SEC24C", "SEC31A", "SEC61A1", "SEC61B", "SEC62", "SEC63", "SEH1L", "SEL1L", "SENP3", "SEPHS1", "SEPT11", "SEPT2", "SEPT7", "SEPT9", "SERBP1", "SERPINB6", "SERPINH1", "SET", "SETD2", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFSWAP", "SFXN1", "SFXN4", "SGPL1", "SGTA", "SH3BGRL3", "SH3GL1", "SH3GLB1", "SH3GLB2", "SHCBP1", "SHMT1", "SHMT2", "SHOC2", "SHTN1", "SIGMAR1", "SIRT1", "SKIV2L", "SKIV2L2", "SKP1", "SKP2", "SLAIN1", "SLC16A1", 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0.0772454186514108 +Sensory transduction 4 7 1.9839692935818367 0.0472592631556114 2.3907766990291264 6.065533980582524 1.0901502088613606 0.2182341455376904 1.4245463862041683 1.4083924790550797 1.1790733646497054 0.2382326050755758 0.1033024001794932 0.0090330503435184 0.03403446937649 0.1637924032376012 0.0139902560164694 +Vision 4 7 1.9839692935818367 0.0472592631556114 2.3470873786407767 5.992718446601942 1.08525596348634 0.2199144433248849 1.3876767838522928 1.281854462283163 1.178949427510656 0.2385050933787637 0.0755162513806922 0.0063255491406275 0.02421661276018 0.1219531221716571 0.0063685282240186 +ER-Golgi transport 11 43 1.9684911893615331 0.0490115488738593 13.189320388349516 50.09466019417476 1.0113245710455496 0.4417664900586612 5.844513029144237 4.526971021787617 1.2802141654412966 0.393016134031976 0.0160645192136559 1.0 0.185657500723835 0.04644869055857 0.000516116301773 diff --git a/protein_atlas_biological_process/metrics.json b/protein_atlas_biological_process/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..d92b42bd1d0f5eba49d0c59411cf597fc2341a56 --- /dev/null +++ b/protein_atlas_biological_process/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2734, + "annotations_size": 162, + "title": "Average number of proteins per term", + "value": 27.753086419753085 +} \ No newline at end of file diff --git a/protein_atlas_biological_process/paths.json b/protein_atlas_biological_process/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..a34006b14930c87da3bf42408d313529960314aa --- /dev/null +++ b/protein_atlas_biological_process/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/protein_atlas_biological_process/fragment/C166/C166_val_log2fc"} \ No newline at end of file diff --git a/protein_atlas_biological_process/result.tsv b/protein_atlas_biological_process/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..99a82f39fda62201628707fcae8954597edc0f69 --- /dev/null +++ b/protein_atlas_biological_process/result.tsv @@ -0,0 +1,49 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Transport 0.4084205943872073 3.5376917511687855 0.000403640981359 0.0633101357649269 0.0072655376644626 432 Q99595,A6NIH7,O60830,Q9BQE5,P21796,Q9H9C1,Q9NS69,O75306,P23786,P46379,P45880,Q9H2D1,Q9H1E5,O43169,O00461,Q13505,Q9Y487,Q96AQ8,Q93050,Q70HW3,O14949,Q13432,O75431,Q9UDW1,Q9Y282,Q99720,O75964,O95197,Q9HD20,P30825,Q8N4H5,Q9UBX3,Q8TB61,P31751,P08183,O43676,Q9BZF3,Q9P2W9,Q9NZJ7,O43772,Q9BTX1,P62072,Q96RQ1,O75381,Q8IXU6,P24390,O15118,Q02978,P16615,Q9BUN8,Q15629,Q8TEX9,Q13190,Q9ULJ7,Q86Y39,P22626,P22059,P61006,A0AVF1,O43681,P51809,P51572,Q9H267,Q9UEU0,Q9Y277,O95168,P14373,P21912,P41440,P35606,O96000,Q9Y6M9,Q9BSK2,Q92945,Q96P70,P11166,O43823,Q9NUL3,Q99442,Q9UM00,Q8TD16,O95202,Q6P4A7,O95487,Q9H4A6,Q6NUQ1,O43615,Q8N1F7,Q8NFH4,Q99523,O14925,O96008,O15126 93 +Sugar transport 0.8945827232796527 2.9543491225795284 0.0031332932131042 0.3985370762845635 0.0253796750261447 2 P31751 1 +Lipid metabolism 0.4217784094845893 2.767851473910658 0.005642716484477 0.600167221831748 0.0403676645267094 109 P09960,P27544,Q16850,P37268,O15118,P23786,Q9BY49,P51648,Q9P035,Q96G23,P35790,Q15392,Q15067,O95470,Q06136,Q9NPH0,Q8NHP8,Q15125,Q9HCL2,Q96N66,O15254,P48651,A1L0T0,Q53GQ0,Q8NCG7,P40939,P04062,O14734,Q15800,Q8NCC3,Q9UBM7,Q14739,Q13011,P48449,O15269,P07602,O00767,Q16836,Q9H7Z7 39 +Cholesterol metabolism 0.6521134255070418 2.759148080142812 0.0057952268253511 0.6099801558154743 0.0403676645267094 22 Q15125,Q15800,Q16850,Q15392,P37268,Q14739,O15118,P04062 8 +Steroid biosynthesis 0.6848062461313746 2.7488543860395978 0.0059803947446976 0.6215731643401797 0.0403676645267094 18 Q15125,Q15800,Q16850,Q15392,Q9UBM7,Q14739,P37268,Q53GQ0,P48449 9 +Sterol metabolism 0.6323580156158335 2.6781158440811716 0.0074037606826815 0.6999695585394796 0.0479763692237765 23 Q15125,Q15800,Q16850,Q15392,P37268,Q14739,O15118,P04062 8 +Lipid biosynthesis 0.5085878326129294 2.6481649233285154 0.0080930032976886 0.7319014294409057 0.0494627128101674 47 Q15125,Q15800,P27544,Q16850,P37268,Q96G23,P35790,Q15392,Q9HCL2,Q96N66,P48651,Q9UBM7,Q14739,P48449,Q9BY49,O00767,Q9P035,Q9H7Z7 18 +Steroid metabolism 0.6192119547797862 2.641918646587067 0.0082437854683612 0.7384234874992015 0.0494627128101674 24 Q15125,Q15800,Q16850,Q15392,P37268,Q14739,O15118,P04062 8 +Translocation 0.5113767839539115 2.6000285821170426 0.0093215996162547 0.7806707940393638 0.0497304983589371 44 Q8NFH4,Q99595,Q8TD16,O60830,Q9NS69,Q15629,Q9BTX1,P62072,O43615,O75381,Q99442,Q8N1F7 12 +Peroxisome biogenesis 0.8052708638360202 2.5368570101101175 0.0111852629758995 0.8383339882117318 0.0517717886313062 2 O14734 1 +Sterol biosynthesis 0.7304498287141482 2.495189896789644 0.0125889738254767 0.8715684995866468 0.0566503822146453 13 Q15125,Q15800,Q16850,Q15392,P37268,Q14739 6 +Cholesterol biosynthesis 0.760662265080936 2.458884305164517 0.0139369522902537 0.897066005796517 0.0589191919147085 12 Q15125,Q15800,Q16850,Q15392,P37268,Q14739 6 +Ion transport 0.5025218787208887 2.452563101252553 0.0141842499053927 0.9011647419557728 0.0589191919147085 42 Q93050,O95202,Q9Y277,O75964,P21796,O96008,Q96S66,P45880,Q8NE01,P51790,Q9Y487,P16615,Q96AQ8,Q9UM00 14 +Coenzyme A biosynthesis 0.7730600292825802 2.381285522116564 0.0172523340036627 0.940350417170253 0.0698719527148342 2 Q13057 1 +Phospholipid metabolism 0.7077034909670895 2.180448281554273 0.0292242485464786 0.991810356424504 0.1029201796636856 12 Q9NPH0,Q9HCL2,P35790,Q96N66 4 +Sensory transduction 0.8059402909656787 1.9839692935818372 0.0472592631556114 0.9996074390770407 0.1472307813694049 7 Q9H6K4,P50897,O43924,Q13432 4 +Vision 0.8059402909656787 1.9839692935818372 0.0472592631556114 0.9996074390770407 0.1472307813694049 7 Q9H6K4,P50897,O43924,Q13432 4 +ER-Golgi transport 0.4486063057097867 1.9684911893615331 0.0490115488738593 0.99970866722596 0.1498088852370796 43 Q9Y282,Q9P2W9,P24390,Q9HCU5,O95197,O95487,O15027,P35606,Q6NUQ1,Q96RQ1,P51572 11 +Protein transport 0.3345651788460934 1.9190539757404756 0.0549775032577082 0.999894893916904 0.1589041294561422 218 Q99595,A6NIH7,O60830,P24390,Q9H9C1,Q9NS69,P35606,Q13505,Q96P70,Q9BUN8,O43823,Q13432,Q15629,Q8TEX9,O75431,Q99442,Q9ULJ7,Q8TD16,Q9HD20,O95487,Q8N4H5,Q9H4A6,Q6NUQ1,O43615,Q8N1F7,Q8NFH4,P61006,Q9P2W9,O14925,O96008,O15126,Q9BTX1,P51572,P62072,A0AVF1,P51809,O75381,Q9H267,Q9UEU0 39 +Electron transport 0.4360134058974234 1.901570119918768 0.0572273773616951 0.9999285622248631 0.1598419850447347 45 Q86Y39,O95168,P21912,O14949,O75306,O96000,Q9H1E5,O43169,O43676,Q9UDW1 10 +Hydrogen ion transport 0.5483784597419027 1.8635881413935689 0.0623795642389539 0.9999705974884802 0.1712794814696702 18 Q93050,Q9Y487 2 +Unfolded protein response 0.7947118427434181 1.828650865176347 0.0674519275585523 0.9999877893422982 0.1734478137219917 6 Q9BUN8 1 +Ubiquinone biosynthesis 0.6504392386530038 1.7652594143791858 0.0775201771886857 0.9999978961543938 0.1932041339164168 2 O75208 1 +Lipid transport 0.5310217871795403 1.7446487977233027 0.0810460211067827 0.9999988686694172 0.1938958819549705 18 O15118,Q9BZF3,Q99720,Q9BQE5 4 +Respiratory chain 0.4644617226294051 1.743774096980539 0.081198488955466 0.9999988986749372 0.1938958819549705 31 Q86Y39,O95168,O14949,O75306,O96000,O43676,Q9UDW1 7 +Phospholipid biosynthesis 0.6581025604439764 1.7426864781106146 0.0813883948946789 0.999998934944385 0.1938958819549705 11 Q9HCL2,P35790,Q96N66 3 +Amino-acid transport 0.7852553865937796 1.6278457775180668 0.1035575911123831 0.9999999796470288 0.2326307068113829 5 P08195,P30825,Q6P4A7 3 +Calcium transport 0.7259326396716062 1.6218875990467445 0.1048274172668577 0.9999999838230332 0.2326307068113829 7 P16615,Q96AQ8,Q9UM00 3 +Sphingolipid metabolism 0.6697297563091918 1.5639996572919874 0.117817648901815 0.9999999984848515 0.2385807390261754 9 O95470,Q06136,O15269,P07602,P04062 5 +Fatty acid metabolism 0.4023873148871888 1.4402168543993998 0.1498060562158141 0.9999999999961812 0.2789492081259986 40 Q8NCC3,Q15067,O15254,A1L0T0,P23786,Q13011,Q9BY49,P40939,O00767,Q16836,Q9H7Z7,P51648,Q9P035 13 +Purine salvage 0.7307209732822201 1.3968979970320632 0.162444247018852 0.9999999999996624 0.2990450911028868 5 P55263 1 +Cilium biogenesis/degradation 0.4506852134967549 1.1785423089447808 0.2385804755886877 1.0 0.3943881331159941 18 A6NIH7,O95684 2 +Viral RNA replication 0.5212298682284136 1.0874464276977462 0.2768395622609434 1.0 0.4329933062985726 2 Q15365 1 +Spermatogenesis 0.4215283056067473 1.0848885689012102 0.2779710114509355 1.0 0.4329933062985726 22 Q9H9C1 1 +Antiport 0.6264824112000673 1.0780965574846244 0.2809906677636447 1.0 0.4335284588353375 6 P41440,O95202,P51790 3 +Symport 0.6367067535050575 1.0062562524486611 0.3142923188279094 1.0 0.4758444453282366 4 P53985 1 +Apoptosis 0.3018300979404299 0.9884997319286823 0.3229079656708897 1.0 0.4843619485063346 110 P21796,P46379,Q9UHX1,Q13546,O95470,P23396,Q6NUQ4,P09601,P05067,Q13153,O95197,Q96KA5,P12236,Q96A26,Q96J02,O60313,P31751,Q9UDX5,Q9NZJ7,Q01085,Q9H3K2,P51572,P31483 23 +Oogenesis 0.4795258251493667 0.5939589132263297 0.5525395938164206 1.0 0.6993079234239074 3 Q9H6S0 1 +GMP biosynthesis 0.4599047967777371 0.5119057147064985 0.6087169984309768 1.0 0.7527645324108263 3 P20839,P12268 2 +Glycogen biosynthesis 0.4521368013636189 0.2967560419249807 0.7666527678705497 1.0 0.8808350950002061 4 P31751 1 +Glycogen metabolism 0.4264276896804718 0.2871711446804539 0.7739812794154219 1.0 0.8823234902707447 7 P31751 1 +Cell shape 0.4340175953079184 0.2808295917991357 0.7788411056093612 1.0 0.8823234902707447 6 P35580,P35579,P15311,Q96AC1,Q7L576 5 +Notch signaling pathway 0.4218903460331955 0.2408569683907465 0.80966597462652 1.0 0.904592330272388 6 P05067 1 +Necrosis 0.4295633973497428 0.2146263346776312 0.8300586602669142 1.0 0.9147585235594564 5 Q13546 1 +Glucose metabolism 0.3751367520902398 0.1711988681793888 0.864067397419392 1.0 0.945803502580686 9 P31751 1 +Heme biosynthesis 0.3366336633663432 0.030517770443841 0.9756541212167592 1.0 1.0 7 P36551,P22830,P08397,P06132,P50336,Q5T440 6 +Pyrimidine biosynthesis 0.3435258276667087 0.0261472229045265 0.979139911491732 1.0 1.0 5 P17812 1 +Host-virus interaction 0.240326239318438 0.011794607363226 0.9905894830718244 1.0 1.0 233 P21796,O60506,O15118,Q7L5N1,P62993,P01889,P61978,Q13546,Q8WTV0,Q9BUN8,Q14108,Q99436,Q15629,Q13363,P08670,O60502,P22626,P49721,O95197,Q9NXV2,P28070,Q96J02,O43760,O14734,Q05086,P29083,Q9ULX6,O75525,P28072,Q01105,P51572 31 diff --git a/protein_atlas_biological_process/selections.json b/protein_atlas_biological_process/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..b8d59e572f245eab203f92059f993cb1c0f5fc24 --- /dev/null +++ b/protein_atlas_biological_process/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["ATP synthesis", "Adaptive immunity", "Amino-acid biosynthesis", "Amino-acid transport", "Angiogenesis", "Antiport", "Antiviral defense", "Apoptosis", "Aromatic hydrocarbons catabolism", "Asparagine biosynthesis", "Autophagy", "B-cell activation", "Behavior", "Biological rhythms", "Biomineralization", "Branched-chain amino acid catabolism", "Calcium transport", "Carbohydrate metabolism", "Catecholamine metabolism", "Cell adhesion", "Cell cycle", "Cell division", "Cell shape", "Chemotaxis", "Cholesterol biosynthesis", "Cholesterol metabolism", "Chromosome partition", "Cilium biogenesis/degradation", "Coenzyme A biosynthesis", "Collagen degradation", "Complement pathway", "DNA condensation", "DNA damage", "DNA excision", "DNA recombination", "DNA repair", "DNA replication", "DNA synthesis", "Detoxification", "Differentiation", "ER-Golgi transport", "Electron transport", "Endocytosis", "Exocytosis", "Fatty acid biosynthesis", "Fatty acid metabolism", "Fertilization", "Fucose metabolism", "GMP biosynthesis", "GPI-anchor biosynthesis", "Galactose metabolism", "Gastrulation", "Gluconate utilization", "Gluconeogenesis", "Glucose metabolism", "Glutathione biosynthesis", "Glycogen biosynthesis", "Glycogen metabolism", "Glycolysis", "Glyoxylate bypass", "Growth arrest", "Growth regulation", "Hearing", "Heme biosynthesis", "Host-virus interaction", "Hydrogen ion transport", "Hypusine biosynthesis", "Immunity", "Inflammatory response", "Inhibition of host STAT1 by virus", "Inhibition of host STAT2 by virus", "Inhibition of host innate immune response by virus", "Inhibition of host interferon signaling pathway by virus", "Innate immunity", "Inositol biosynthesis", "Ion transport", "Isoprene biosynthesis", "Leukotriene biosynthesis", "Lipid biosynthesis", "Lipid degradation", "Lipid metabolism", "Lipid transport", "Meiosis", "Melanin biosynthesis", "Methionine biosynthesis", "Methotrexate resistance", "Mitosis", "Molybdenum cofactor biosynthesis", "Myogenesis", "Necrosis", "Neurogenesis", "Neurotransmitter degradation", "Neurotransmitter transport", "Nonsense-mediated mRNA decay", "Notch signaling pathway", "Nucleotide biosynthesis", "Nucleotide metabolism", "One-carbon metabolism", "Oogenesis", "Osteogenesis", "Pentose shunt", "Peroxisome biogenesis", "Phagocytosis", "Phenylalanine catabolism", "Phospholipid biosynthesis", "Phospholipid metabolism", "Plasminogen activation", "Polyamine biosynthesis", "Porphyrin biosynthesis", "Potassium transport", "Proline biosynthesis", "Prostaglandin biosynthesis", "Prostaglandin metabolism", "Protein biosynthesis", "Protein transport", "Purine biosynthesis", "Purine salvage", "Pyridine nucleotide biosynthesis", "Pyrimidine biosynthesis", "RNA-mediated gene silencing", "Respiratory chain", "Ribosome biogenesis", "Sensory transduction", "Serine biosynthesis", "Sodium transport", "Sodium/potassium transport", "Spermatogenesis", "Spermidine biosynthesis", "Sphingolipid metabolism", "Steroid biosynthesis", "Steroid metabolism", "Steroidogenesis", "Sterol biosynthesis", "Sterol metabolism", "Stress response", "Sugar transport", "Symport", "Tetrahydrobiopterin biosynthesis", "Transcription", "Transcription regulation", "Transcription termination", "Translation regulation", "Translocation", "Transport", "Tricarboxylic acid cycle", "Tyrosine catabolism", "Ubiquinone biosynthesis", "Ubl conjugation pathway", "Unfolded protein response", "Viral RNA replication", "Viral immunoevasion", "Viral penetration into host nucleus", "Virus entry into host cell", "Vision", "Wnt signaling pathway", "Xylose metabolism", "mRNA capping", "mRNA processing", "mRNA splicing", "mRNA transport", "rRNA processing", "tRNA processing"], "available_proteins": ["AAAS", "AAR2", "AARS", "AARS2", "AARSD1", "ABCB1", "ABCB10", "ABCB7", "ABCD3", "ABCE1", "ABHD12", "ABHD6", "ACAA2", "ACACA", "ACACB", "ACADM", "ACADVL", "ACAT1", "ACBD3", "ACBD5", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT7", "ACOT8", "ACOX1", "ACOX3", "ACP6", "ACSL1", "ACSL3", "ACSL4", "ACTN4", "ACTR3", "ADA", "ADAR", "ADI1", "ADK", "ADNP", "ADPGK", "ADPRHL2", "ADSL", "ADSS", "AFDN", "AGL", "AGPAT1", "AGPS", "AHCTF1", "AHCY", "AHCYL1", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AKAP8", "AKAP8L", "AKT2", "ALDH18A1", "ALDH3A2", "ALDOA", "ALDOC", "ALKBH5", "ANAPC1", "ANAPC16", "ANAPC4", "ANAPC5", "ANAPC7", "ANKFY1", "ANKLE2", "ANKRD50", "ANLN", "ANP32A", "ANP32B", "ANXA1", "ANXA11", "ANXA2", "AP1B1", "AP1G1", "AP1M1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "APC", "APEX1", "API5", "APOL2", "APP", "APPL1", "APRT", "AQR", "ARCN1", "ARF4", "ARF5", "ARFGAP1", "ARFIP2", "ARHGEF2", "ARID1A", "ARID3B", "ARIH1", "ARL2", "ARL3", "ARL6IP1", "ARL8B", "ARMT1", "ASAH1", "ASCC3", "ASF1A", "ASNA1", "ASNS", "ATAD5", "ATE1", "ATG7", "ATIC", "ATP13A1", "ATP1A1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5L", "ATP5O", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1D", "ATP6V1E1", "ATP6V1H", "AUP1", "AURKA", "BABAM1", "BAG6", "BAK1", "BANF1", "BAZ1A", "BAZ1B", "BCAP31", "BCAS2", "BCAS3", "BCCIP", "BCL2L13", "BCLAF1", "BICD2", "BIRC6", "BMS1", "BNIP1", "BOP1", "BPTF", "BRAT1", "BRD4", "BRIX1", "BSG", "BTF3", "BUB1", "BUB1B", "BUB3", "BUD31", "BYSL", "BZW1", "BZW2", "C12orf43", "C1QBP", "CACYBP", "CAD", "CAMK2G", "CAND1", "CANX", "CAPRIN1", "CARM1", "CARS", "CARS2", "CASP3", "CASP6", "CASP7", "CASP8", "CBX3", "CBX5", "CBX8", "CCAR1", "CCAR2", "CCDC124", "CCDC22", "CCDC86", "CCDC93", "CCDC94", "CCNB1", "CD2AP", "CD2BP2", "CD3EAP", "CD47", "CDC123", "CDC16", "CDC23", "CDC27", "CDC40", "CDC42", "CDC45", "CDC5L", "CDC73", "CDCA5", "CDIPT", "CDK1", "CDK12", "CDK2", "CDK4", "CDK5RAP3", "CDK6", "CDS2", "CDX2", "CEBPZ", "CELF1", "CENPV", "CEP55", "CERS1", "CERS2", "CETN2", "CFL1", "CGGBP1", "CHAF1B", "CHCHD3", "CHD1", "CHD4", "CHEK2", "CHID1", "CHKA", "CHMP1A", "CHMP2B", "CHMP5", "CHMP6", "CHMP7", "CHORDC1", "CHST14", "CIAPIN1", "CIRBP", "CISD2", "CKAP2", "CKAP5", "CLASP1", "CLCC1", "CLCN3", "CLIC1", "CLIC4", "CLINT1", "CLPTM1", "CLPTM1L", "CLTA", "CLTC", "CMPK1", "CNNM3", "CNNM4", "CNOT1", "CNOT7", "CNOT9", "COASY", "COG2", "COG6", "COMMD4", "COMT", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS6", "COPS7A", "COPS7B", "COPZ1", "COQ8A", "COQ9", "COX2", "CPNE1", "CPOX", "CPSF1", "CPSF2", "CPSF3", "CPSF6", "CPSF7", "CPT1A", "CPT2", "CRNKL1", "CS", "CSE1L", "CSK", "CSNK1A1", "CSNK2A2", "CSNK2B", "CSTF1", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTPS2", "CTR9", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4A", "CUL4B", "CUL5", "CYB5B", "CYB5D2", "CYB5R3", "CYC1", "CYFIP1", "CYP51A1", "DAD1", "DAGLB", "DAP3", "DARS", "DARS2", "DAZAP1", "DBN1", "DBNL", "DCAF1", "DCAF13", "DCAF7", "DCP1A", "DCPS", "DCTD", "DCTN1", "DCTN3", "DCXR", "DDB1", "DDRGK1", "DDT", "DDX1", "DDX17", "DDX20", "DDX21", "DDX23", "DDX28", "DDX39A", "DDX39B", "DDX3X", "DDX41", "DDX46", "DDX47", "DDX5", "DDX51", "DDX54", "DDX56", "DENR", "DERL1", "DFFA", "DHCR24", "DHCR7", "DHFR", "DHPS", "DHX15", "DHX16", "DHX30", "DHX36", "DHX38", "DHX8", "DHX9", "DIABLO", "DIAPH1", "DICER1", "DIDO1", "DIP2B", "DIS3", "DKC1", "DLAT", "DLST", "DNAAF5", "DNAJA3", "DNAJB1", "DNAJC2", "DNAJC3", "DNM1L", "DNM2", "DNMT1", "DNPH1", "DNTTIP2", "DOCK7", "DOHH", "DPF2", "DPYSL2", "DSG2", "DST", "DTL", "DTYMK", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNLL1", "DYNLL2", "EARS2", "EBNA1BP2", "EBP", "ECD", "ECH1", "ECHS1", "ECI1", "ECSIT", "EDF1", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EEFSEC", "EFL1", "EFTUD2", "EHD1", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2D", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAC2", "ELOB", "ELOC", "ELP1", "ELP2", "ELP3", "EMC4", "EMG1", "EML4", "ENO1", "ENSA", "EPB41", "EPB41L2", "EPB41L3", "EPHX1", "EPHX2", "EPRS", "EPS15", "EPS15L1", "ERAL1", "ERAP1", "ERCC2", "ERCC3", "ERGIC2", "ERGIC3", "ERH", "ERLIN1", "ERLIN2", "ERO1A", "ERP44", "ESF1", "ESYT1", "ESYT2", "ETF1", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXO1", "EXOC1", "EXOC2", "EXOC4", "EXOC5", "EXOC7", "EXOSC10", "EXOSC3", "EXOSC4", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC8", "EZR", "F11R", "FABP5", "FADS2", "FAF1", "FAF2", "FAH", "FAM162A", "FAM208A", "FAM50A", "FANCI", "FAR1", "FARSA", "FARSB", "FASN", "FASTKD2", "FBL", "FBXO22", "FBXO7", "FDFT1", "FDPS", "FDX1", "FDXR", "FECH", "FEN1", "FERMT2", "FGFR1OP", "FH", "FHL1", "FIP1L1", "FIS1", "FKBP8", "FLII", "FLNA", "FLNB", "FLOT2", "FMR1", "FOXC1", "FOXRED1", "FRYL", "FTSJ1", "FTSJ3", "FUBP1", "FUBP3", "FXR1", "G3BP1", "G3BP2", "G6PD", "GABARAPL2", "GADD45GIP1", "GALK1", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GATAD2B", "GATB", "GATC", "GBA", "GBE1", "GBF1", "GCC2", "GCLM", "GCN1", "GEMIN4", "GEMIN5", "GET4", "GFM1", "GFPT1", "GGA1", "GHITM", "GINS2", "GINS3", "GINS4", "GM2A", "GMPS", "GNAI1", "GNAI2", "GNAI3", "GNL2", "GNL3L", "GNPDA1", "GOLIM4", "GOLPH3", "GOLT1B", "GORASP2", "GOT1", "GOT2", "GPAM", "GPHN", "GPI", "GPKOW", "GPR89B", "GRB2", "GRSF1", "GRWD1", "GSK3A", "GSK3B", "GSPT1", "GSS", "GSTZ1", "GTF2B", "GTF2E1", "GTF2F1", "GTF2F2", "GTF2I", "GTF3C1", "GTF3C2", "GTF3C3", "GTPBP10", "GTPBP3", "GTPBP4", "GYG1", "H2AFX", "HACD3", "HADH", "HADHA", "HADHB", "HAUS4", "HAUS5", "HBS1L", "HCFC1", "HDAC2", "HDGF", "HDLBP", "HEATR1", "HECTD1", "HELLS", "HGS", "HIBADH", "HIBCH", "HINT2", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLTF", "HMBS", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMGCS1", "HMOX1", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH3", "HNRNPK", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HOOK3", "HPRT1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSP90AA1", "HSP90AB1", "HSPA1B", "HSPA2", "HSPA4", "HSPA4L", "HSPA8", "HSPB1", "HSPD1", "HSPE1", "HSPH1", "HTATSF1", "HTT", "HUS1", "HUWE1", "HYOU1", "IARS", "IARS2", "IBA57", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDI1", "IFIT5", "IFT27", "IGBP1", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IK", "ILF2", "ILF3", "ILVBL", "IMP3", "IMPDH1", "IMPDH2", "INA", "INTS13", "INTS3", "INTS7", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IST1", "ISYNA1", "ITCH", "ITGB1", "ITPA", "IVD", "IWS1", "JUP", "KARS", "KAT7", "KCTD5", "KDELR1", "KDM1A", "KDM1B", "KDM2A", "KDM3B", "KDSR", "KHDRBS1", "KHDRBS3", "KHSRP", "KIAA0319L", "KIAA1468", "KIF11", "KIF20A", "KIF23", "KIF2A", "KIF2C", "KIF3A", "KIFBP", "KIFC1", "KLC1", "KPNA1", "KPNA2", "KPNA3", "KPNA6", "KPNB1", "LAMP1", "LAMP2", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LAS1L", "LASP1", "LBR", "LDLR", "LETM1", "LGALS3", "LGALS3BP", "LIG1", "LIG3", "LIMA1", "LIPA", "LLGL1", "LMAN1", "LMAN2", "LPCAT1", "LPP", "LRPPRC", "LSM6", "LSM7", "LSM8", "LSS", "LTA4H", "LYAR", "LYPLA1", "M6PR", "MACF1", "MAD1L1", "MAD2L1", "MAGT1", "MAP1S", "MAPK1", "MAPK14", "MAPRE1", "MAPRE2", "MARS", "MARS2", "MASTL", "MAT2A", "MAT2B", "MATR3", "MAU2", "MAVS", "MBNL1", "MBOAT7", "MCAT", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCMBP", "MCTS1", "MCU", "MCUR1", "MDC1", "MDH1", "MDH2", "MEAF6", "MECP2", "MED1", "MED24", "MESD", "MFAP1", "MFN2", "MFSD5", "MGEA5", "MGME1", "MGST2", "MIA3", "MICU1", "MID1", "MIF", "MKI67", "MLEC", "MMS19", "MON2", "MORF4L1", "MOSPD2", "MOV10", "MPDU1", "MPHOSPH10", "MRC2", "MRE11", "MRPL58", "MRPS27", "MRTO4", "MSH2", "MSH3", "MSH6", "MSMO1", "MSN", "MTA1", "MTAP", "MTBP", "MTCH1", "MTCH2", "MTFP1", "MTHFD1L", "MTHFD2", "MTOR", "MTPAP", "MTR", "MTX1", "MTX2", "MYBBP1A", "MYCBP", "MYDGF", "MYH10", "MYH14", "MYH9", "MYO1D", "MYO6", "NAA15", "NAE1", "NAF1", "NAMPT", "NAP1L1", "NAPA", "NAPG", "NARS", "NASP", "NAT10", "NAXE", "NBN", "NCAPD2", "NCAPG", "NCAPH", "NCBP1", "NCBP2", "NCKAP1", "NCOA5", "NCSTN", "NDC1", "NDUFA10", "NDUFA11", "NDUFA13", "NDUFA2", "NDUFA4", "NDUFA5", "NDUFA7", "NDUFA8", "NDUFA9", "NDUFAF4", "NDUFB10", "NDUFB11", "NDUFB3", "NDUFB4", "NDUFB5", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS7", "NDUFS8", "NDUFV1", "NDUFV2", "NECAP2", "NEK9", "NELFA", "NELFCD", "NELFE", "NES", "NFKB1", "NFS1", "NHP2", "NIP7", "NISCH", "NKRF", "NLE1", "NMD3", "NME1", "NME2", "NOC2L", "NOL11", "NOL8", "NOL9", "NONO", "NOP10", "NOP14", "NOP2", "NOP56", "NOP58", "NOSIP", "NPC1", "NPLOC4", "NPM1", "NSA2", "NSD2", "NSDHL", "NSF", "NSUN2", "NSUN5", "NT5C2", "NT5C3B", "NUBP2", "NUCKS1", "NUDC", "NUDCD1", "NUDT21", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP160", "NUP188", "NUP205", "NUP210", "NUP214", "NUP35", "NUP37", "NUP50", "NUP54", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NUTF2", "NVL", "NXF1", "NXN", "OGDH", "OGT", "OPA1", "OPA3", "OSBP", "OSBPL11", "OSBPL6", "OSBPL8", "OSBPL9", "OSGEP", "OTUB1", "PA2G4", "PABPC1", "PABPN1", "PACSIN2", "PACSIN3", "PAF1", "PAFAH1B1", "PAFAH1B3", "PAICS", "PAK1", "PAK1IP1", "PAK2", "PANK4", "PARK7", "PARN", "PARP1", "PARP2", "PBRM1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCID2", "PCK2", "PCLAF", "PCM1", "PCNA", "PCNP", "PDCD11", "PDCD4", "PDCD5", "PDCD6", "PDCD6IP", "PDCL3", "PDE12", "PDE6D", "PDHA1", "PDHB", "PDK3", "PDLIM7", "PDS5A", "PDS5B", "PECR", "PELO", "PELP1", "PEPD", "PES1", "PEX14", "PEX19", "PEX5", "PFAS", "PFKL", "PFKM", "PFKP", "PGAM1", "PGAM5", "PGD", "PGK1", "PGM1", "PGM2", "PGP", "PHB", "PHB2", "PHF5A", "PHF6", "PHF8", "PHGDH", "PI4KB", "PICALM", "PIGK", "PIGS", "PIH1D1", "PIK3C3", "PIN1", "PIR", "PISD", "PITHD1", "PITPNA", "PITPNB", "PKM", "PKMYT1", "PKN1", "PKN2", "PLA2G15", "PLAA", "PLBD2", "PLCG1", "PLD3", "PLD6", "PLIN3", "PLK1", "PLRG1", "PNN", "PNP", "PNPLA8", "PNPT1", "POFUT1", "POGZ", "POLA1", "POLA2", "POLD1", "POLDIP2", "POLDIP3", "POLE", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2B", "POLR2C", "POLR2E", "POLR2G", "POLR2L", "POLR3A", "POLRMT", "POP1", "PPAT", "PPID", "PPIE", "PPIF", "PPIH", "PPIL1", "PPOX", "PPP1CA", "PPP1CB", "PPP1R8", "PPP2R1A", "PPP5C", "PPP6C", "PPT1", "PQBP1", "PRAF2", "PRC1", "PRCC", "PRDX6", "PREB", "PRIM1", "PRIM2", "PRKAG1", "PRKDC", "PRKRA", "PRMT5", "PRPF19", "PRPF3", "PRPF31", "PRPF38B", "PRPF39", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPS2", "PRPSAP1", "PRPSAP2", "PSAP", "PSAT1", "PSIP1", "PSMA1", "PSMA3", "PSMA4", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC3", "PSMD10", "PSMD14", "PSME3", "PSME4", "PSPC1", "PTBP1", "PTBP2", "PTCD1", "PTCD3", "PTDSS1", "PTGES2", "PTGES3", "PTGR1", "PTK7", "PTRH2", "PUF60", "PUM1", "PURA", "PUS7", "PWP1", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QDPR", "QKI", "QRSL1", "RAB10", "RAB11B", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB1B", "RAB24", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RAB8A", "RAB8B", "RAB9A", "RABEP1", "RABGAP1", "RACK1", "RAD21", "RAD23A", "RAD23B", "RAD50", "RAD9A", "RAE1", "RAI14", "RALA", "RALB", "RALY", "RAN", "RANBP2", "RANBP3", "RAPGEF2", "RARS", "RARS2", "RBBP5", "RBBP6", "RBM10", "RBM14", "RBM17", "RBM22", "RBM25", "RBM28", "RBM3", "RBM39", "RBM4", "RBM4B", "RBM5", "RBM8A", "RBMX", "RBMXL1", "RBPMS", "RCC1", "RCC2", "RCL1", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RFX1", "RHOA", "RIF1", "RINT1", "RIOX2", "RIPK1", "RNASET2", "RNF14", "RNF20", "RNF219", "RNF40", "RNPS1", "ROCK2", "RP2", "RPA1", "RPA2", "RPAP1", "RPF2", "RPL10", "RPL13A", "RPP30", "RPRD1B", "RPS3", "RPS3A", "RPS6KA1", "RPS6KA3", "RPSA", "RRBP1", "RRM1", "RRM2", "RRP1", "RRP1B", "RRP8", "RRS1", "RSF1", "RTCB", "RTN3", "RTN4", "RTN4IP1", "RTRAF", "RUFY1", "RUVBL1", "RUVBL2", "S100A13", "SAE1", "SAFB", "SAFB2", "SAMHD1", "SAP130", "SAP18", "SAR1A", "SARNP", "SARS", "SARS2", "SART1", "SART3", "SBDS", "SC5D", "SCAF1", "SCAF4", "SCAMP1", "SCAMP2", "SCAMP3", "SCARB1", "SCARB2", "SCD", "SCFD1", "SCML2", "SCP2", "SCRIB", "SCRN1", "SDF4", "SDHA", "SDHB", "SEC16A", "SEC22B", "SEC23A", "SEC23B", "SEC24A", "SEC24B", "SEC24C", "SEC31A", "SEC61A1", "SEC61B", "SEC62", "SEC63", "SEH1L", "SEL1L", "SENP3", "SEPT11", "SEPT2", "SEPT7", "SEPT9", "SERPINH1", "SET", "SETD2", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFSWAP", "SFXN1", "SFXN4", "SGPL1", "SGTA", "SH3GL1", "SH3GLB1", "SHMT1", "SHMT2", "SIGMAR1", "SIRT1", "SKIV2L2", "SKP1", "SKP2", "SLC16A1", "SLC19A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A17", "SLC25A20", "SLC25A22", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A33", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A4", "SLC29A1", "SLC2A1", "SLC33A1", "SLC35B2", "SLC35F2", "SLC3A2", "SLC7A1", "SLC9A3R1", "SLFN11", "SLIRP", "SLIT2", "SLK", "SLTM", "SMARCA1", "SMARCA4", "SMARCAD1", "SMARCC1", "SMARCC2", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC6", "SMCHD1", "SMN1*", "SMNDC1", "SMU1", "SNAP23", "SNAP29", "SND1", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNU13", "SNW1", "SNX1", "SNX12", "SNX17", "SNX2", "SNX27", "SNX3", "SNX5", "SNX6", "SNX9", "SOAT1", "SON", "SORT1", "SPC24", "SPC25", "SPECC1L", "SPEN", "SPOUT1", "SPTLC1", "SPTLC2", "SQSTM1", "SREK1", "SRM", "SRPK1", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF3", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSBP1", "SSRP1", "STAG1", "STAG2", "STAM", "STAMBP", "STARD3", "STAT1", "STAT3", "STAU1", "STAU2", "STK4", "STMN1", "STRAP", "STRBP", "STUB1", "STX12", "STX18", "STX5", "STXBP3", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGP2", "SUGT1", "SUN1", "SUPT16H", "SUPT5H", "SUPT6H", "SUZ12", "SV2A", "SYAP1", "SYMPK", "SYNCRIP", "SYNGR2", "TACC3", "TALDO1", "TAMM41", "TARDBP", "TARS", "TARS2", "TCAF1", "TCEA1", "TCERG1", "TDP2", "TDRKH", "TECR", "TERF2IP", "TEX264", "TFAM", "TFCP2", "TFG", "TFRC", "THOC1", "THOC2", "THOC3", "THOC6", "THRAP3", "TIA1", "TIAL1", "TIGAR", "TIMM10", "TIMM17A", "TIMM17B", "TIMM23", "TIMM44", "TIMM50", "TIMM8B", "TK1", "TLN1", "TMCO1", "TMED10", "TMED2", "TMED5", "TMED7", "TMED9", "TMEM109", "TMEM14C", "TMEM214", "TMX1", "TMX4", "TNPO1", "TNPO2", "TNPO3", "TOLLIP", "TOMM20", "TOMM22", "TOMM40", "TOMM5", "TOMM70", "TOP1", "TOP2A", "TP53", "TP53BP1", "TPI1", "TPR", "TPX2", "TRA2A", "TRA2B", "TRAM1", "TRAPPC5", "TRIM21", "TRIM24", "TRIM25", "TRIM26", "TRIM27", "TRIM28", "TRIM33", "TRIM35", "TRIP12", "TRIP13", "TRMT10C", "TRMT1L", "TROVE2", "TSFM", "TSG101", "TSNAX", "TSR1", "TTC19", "TTC26", "TTC4", "TTF2", "TTLL12", "TTYH3", "TUBB2B", "TUFM", "TWF2", "TXLNA", "TXLNG", "TXNL1", "TXNRD1", "TYMS", "U2AF1", "U2AF2", "UBA1", "UBA2", "UBA3", "UBA6", "UBE2G2", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2O", "UBE2S", "UBE3A", "UBE4B", "UBQLN4", "UBR4", "UBR5", "UBTF", "UBXN1", "UCHL5", "UFC1", "UFD1", "UFL1", "UFM1", "UGDH", "UHRF1", "UMPS", "UNC119", "UNC119B", "UNC45A", "UNG", "UPF1", "UQCR10", "UQCRB", "UQCRC1", "UQCRC2", "UQCRQ", "UROD", "USO1", "USP10", "USP11", "USP14", "USP15", "USP39", "USP47", "USP48", "USP5", "USP7", "USP9X", "UTP11", "UTP14A", "UTP15", "UTP18", "UTP20", "UTP4", "UTP6", "VAMP7", "VAPA", "VAPB", "VARS1", "VARS2", "VCL", "VCP", "VDAC1", "VDAC2", "VDAC3", "VIM", "VIPAS39", "VIRMA", "VMP1", "VPS18", "VPS26A", "VPS29", "VPS33A", "VPS33B", "VPS35", "VPS4B", "VPS52", "VRK1", "VTA1", "VTI1B", "WAPL", "WARS", "WASHC4", "WBP11", "WDR36", "WDR41", "WDR43", "WDR5", "WDR6", "WDR61", "WDR75", "WIPI2", "WTAP", "XAB2", "XPO1", "XPO5", "XPO7", "XPOT", "XRCC1", "XRCC5", "XRCC6", "XRN2", "YARS", "YARS2", "YBX1", "YBX3", "YEATS4", "YKT6", "YLPM1", "YTHDC1", "YTHDC2", "YTHDF2", "YTHDF3", "YWHAB", "YWHAE", "ZC3H11A", "ZC3HAV1", "ZC3HC1", "ZCCHC3", "ZCCHC8", "ZMYM2", "ZNF207", "ZNF24", "ZNF281", "ZNF318", "ZNF326", "ZNF638", "ZPR1", "ZW10", "ZYX"], "leading_proteins": ["ABCB1", "ACOT8", "ACOX1", "ACOX3", "ACP6", "ADK", "AKAP8", "AKAP8L", "AKT2", "ALDH3A2", "ANKRD50", "APOL2", "APP", "ASNA1", "ATP13A1", "ATP2A2", "ATP5L", "ATP6V0A1", "ATP6V0A2", "BAG6", "BCAP31", "BICD2", "CERS1", "CERS2", "CHKA", "CLCC1", "CLCN3", "CLPTM1L", "CNNM3", "COASY", "COPB2", "COPS6", "COQ9", "CPOX", "CPT2", "CTBP1", "CTPS1", "CYB5B", "CYFIP1", "CYP51A1", "DAGLB", "DERL1", "DHCR24", "DHCR7", "EBP", "ECH1", "ERGIC2", "ERGIC3", "EZR", "FAM162A", "FDFT1", "FECH", "FERMT2", "FGFR1OP", "GBA", "GHITM", "GOLIM4", "GOLPH3", "GPAM", "GRB2", "GTF2E1", "HACD3", "HADH", "HADHA", "HLA-B", "HMBS", "HMOX1", "HNRNPA2B1", "HNRNPK", "HSD17B12", "IBA57", "ILVBL", "IMPDH1", "IMPDH2", "IPO4", "IPO9", "ITCH", "KCTD5", "KDELR1", "KDSR", "KHDRBS3", "KHSRP", "LBR", "LETM1", "LSS", "LTA4H", "MBOAT7", "MCUR1", "MGEA5", "MSMO1", "MTCH1", "MTFP1", "MTX1", "MTX2", "MYH10", "MYH9", "NDC1", "NDUFA11", "NDUFB10", "NDUFB3", "NDUFB4", "NDUFB9", "NDUFS2", "NPC1", "NUP37", "NUP93", "OPA1", "OPA3", "OSBP", "OSBPL6", "PAK1", "PCBP1", "PDE6D", "PECR", "PEX14", "PLA2G15", "PLBD2", "PPOX", "PPT1", "PREB", "PSAP", "PSMB2", "PSMB4", "PSMB6", "PSMB7", "PTDSS1", "PTGES2", "PUF60", "RAB8A", "RINT1", "RIPK1", "RPS3", "RTN3", "SCAMP1", "SCARB1", "SCARB2", "SCD", "SDHB", "SEC16A", "SEC24B", "SEC62", "SET", "SFXN4", "SGPL1", "SIGMAR1", "SLC16A1", "SLC19A1", "SLC25A10", 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setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Proto-oncogene 10 35 2.44143316928868 0.0146290957412338 10.220873786407768 42.230582524271846 0.352417122717188 0.6349839081636985 4.025676233803451 6.092151297173746 0.7870476016467428 0.3240376141995099 0.1365772806425679 0.5147372580778585 0.176207393407033 0.0284019582092283 0.0599053088547943 diff --git a/protein_atlas_disease_involvement/metrics.json b/protein_atlas_disease_involvement/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..cc5dcb3cb0c4305f18e1f509936527c872b484cb --- /dev/null +++ b/protein_atlas_disease_involvement/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2734, + "annotations_size": 112, + "title": "Average number of proteins per term", + "value": 19.598214285714285 +} \ No newline at end of file diff --git a/protein_atlas_disease_involvement/paths.json b/protein_atlas_disease_involvement/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..090a8e52bc66b83a9847b69048ee7ec0faae8e4c --- /dev/null +++ b/protein_atlas_disease_involvement/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/protein_atlas_disease_involvement/fragment/C166/C166_val_log2fc"} \ No newline at end of file diff --git a/protein_atlas_disease_involvement/result.tsv b/protein_atlas_disease_involvement/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..f3890cd88bcb8512d71f311c4f290515a791c97d --- /dev/null +++ b/protein_atlas_disease_involvement/result.tsv @@ -0,0 +1,34 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Gaucher disease 0.920571010248904 3.072102397651845 0.0021255679567004 0.2120471141495799 0.0182698537418462 2 P07602 1 +Hirschsprung disease 0.8510248901903441 2.7532549746477355 0.005900592103182 0.4846060765139564 0.0330433157778195 2 P42892 1 +Proto-oncogene 0.5217017411256073 2.44143316928868 0.0146290957412338 0.8080578947946104 0.0564985766557996 35 P61006,P35637,P14373,Q06136,Q16204,Q01105,Q92804,Q01844,Q8WY22,P31751 10 +Rhizomelic chondrodysplasia punctata 0.7631771595900455 2.3330171008267304 0.0196472478045754 0.8916508002522817 0.068523368373321 2 P50542 1 +Xeroderma pigmentosum 0.7573206442166887 2.3042951317088667 0.0212060820595545 0.9093388235624592 0.068523368373321 2 P19447 1 +Cockayne syndrome 0.7573206442166887 2.3042951317088667 0.0212060820595545 0.9093388235624592 0.068523368373321 2 P19447 1 +Neuronal ceroid lipofuscinosis 0.8473086781398754 2.2791715492748907 0.0226568696298434 0.9232159090488452 0.068582956717364 3 P50897,O75503 2 +Premature ovarian failure 0.7364568081991247 2.201260826322706 0.0277175644005081 0.9570707494335554 0.0816938740225501 2 Q5JTZ9 1 +Zellweger syndrome 0.8055657268399853 2.094295587809016 0.0362336571439796 0.9839735761482352 0.094376037212226 3 P50542,O75381 2 +Peroxisome biogenesis disorder 0.8055657268399853 2.094295587809016 0.0362336571439796 0.9839735761482352 0.094376037212226 3 P50542,O75381 2 +Ehlers-Danlos syndrome 0.846536824589645 1.890483162790449 0.0586933703332712 0.9988574238484874 0.1429055973331822 4 Q8NCH0,Q9NWM8 2 +Cataract 0.4839209850967835 1.6709828420515616 0.0947250669096626 0.9999855650448256 0.2080236763506317 25 Q15125,P11166,Q15800,Q9H6K4,P48449,P08670 6 +Allergen 0.6174963396778956 1.5940785734720468 0.1109184373119425 0.999998088124242 0.2343936788478785 2 Q9BPX6 1 +Primary microcephaly 0.7094462820350494 1.5459589690293805 0.1221144774761213 0.9999995375728288 0.2486694814059198 7 P35606,Q86XL3 2 +Ichthyosis 0.6151214757952552 1.290222082153914 0.1969735612223611 0.9999999999786332 0.3739159128288888 9 Q15125,P51648 2 +Hypotrichosis 0.6991461320352031 1.2621676998868798 0.2068884486951261 0.9999999999946858 0.3861917708975688 5 P48449 1 +Mucopolysaccharidosis 0.6833233533356426 1.1945486759071091 0.2322634120075419 0.9999999999998608 0.4264508548335197 5 P08236 1 +Primary mitochondrial disease 0.3268125906944975 1.143430220702046 0.2528600110743806 0.9999999999999932 0.4567793748440423 81 Q9Y2R0,Q86Y39,Q6P4A7,P13073,Q70HW3,Q9H845,Q9NX14,O14949,Q9H0R6,Q96IX5,O75306,Q99797,Q9UBX3,Q9P0J0,Q9Y6M9,Q7KZN9,O60313,O43676 18 +Limb-girdle muscular dystrophy 0.5343761744865119 0.6715065973668409 0.5018978580557465 1.0 0.78073000142005 6 P02545,Q9Y5P6,O14979 3 +Parkinson disease 0.5179200363564331 0.6602114775424692 0.5091181278368073 1.0 0.7811127440783893 7 Q96A57 1 +Emery-Dreifuss muscular dystrophy 0.5451848884984899 0.6177425073828448 0.5367450870009387 1.0 0.8015393299214019 5 P02545,P50402 2 +Congenital myasthenic syndrome 0.4738191138777006 0.5697560525277682 0.5688431666329028 1.0 0.8152078865480225 3 P53007,Q4J6C6 2 +Hereditary spastic paraplegia 0.3960343213372809 0.534756083968888 0.5928185342464667 1.0 0.8152078865480225 13 Q8N0X7,O75298,Q5T440,Q9H0B6 4 +Congenital disorder of glycosylation 0.377849397493954 0.5269189909678907 0.59824984523226 1.0 0.8152078865480225 15 Q8N511,P46977 2 +Congenital muscular dystrophy 0.4615062488575684 0.5184744628686917 0.6041272730668381 1.0 0.8152078865480225 3 Q9Y5P6 1 +Dystonia 0.4693248308801176 0.4077109961550509 0.6834858635193382 1.0 0.890121124583324 6 P51572 1 +Amyotrophic lateral sclerosis 0.3583739520264417 0.368771500658884 0.7122980489637518 1.0 0.898561470141482 14 P35637,P43243,Q99720 3 +Neurodegeneration 0.2574183633802718 0.2698803134486179 0.7872523329862353 1.0 0.9689259482907512 120 Q13057,P27544,P50897,Q8TB36,Q96A57,P07196,Q8IV08,P06865,O14773,Q14108,P35637,Q16637,Q96BR5,P02545,P05023,P54802,Q10713,P05067,P09651,O75503,Q8TD16,O75298,Q99720,P50570,Q15120,Q5JTZ9,P04062,O60313,Q9H0B6,Q8N0X7,Q14671,O15269,P43243,Q9Y320 34 +Parkinsonism 0.397989775665298 0.2555760383043791 0.7982782226904603 1.0 0.971816966753604 9 Q96A57 1 +Diabetes mellitus 0.3761375297923536 0.1746987672851056 0.8613163364437466 1.0 1.0 9 P31751 1 +FDA approved drug targets 0.2458174744924398 0.1247124232088855 0.900751221892305 1.0 1.0 107 Q16850,Q8N0U8,P23786,P16615,Q16637,P21964,Q99707,P30043,P36507,P05067,P00813,P38435,Q14534,Q99720,P49721,P62942,P20618,Q13423,P49356,P31350,Q16836 21 +Williams-Beuren syndrome 0.3792598021253136 0.0901175288219891 0.9281938199097252 1.0 1.0 5 Q96P11,Q15056,P35250,P78347 4 +Alzheimer disease 0.3573141865990107 0.0483702365470139 0.961421179324154 1.0 1.0 5 P05067 1 diff --git a/protein_atlas_disease_involvement/selections.json b/protein_atlas_disease_involvement/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..f00627644f7d0c69beb9bb59f8adaf7e81936bf9 --- /dev/null +++ b/protein_atlas_disease_involvement/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["Aicardi-Goutieres syndrome", "Albinism", "Allergen", "Alport syndrome", "Alzheimer disease", "Amelogenesis imperfecta", "Amyloidosis", "Amyotrophic lateral sclerosis", "Atrial fibrillation", "Autism", "Autism spectrum disorder", "Bardet-Biedl syndrome", "Bartter syndrome", "Cancer-related genes", "Cardiomyopathy", "Cataract", "Charcot-Marie-Tooth disease", "Ciliopathy", "Cockayne syndrome", "Cone-rod dystrophy", "Congenital adrenal hyperplasia", "Congenital disorder of glycosylation", "Congenital dyserythropoietic anemia", "Congenital hypothyroidism", "Congenital muscular dystrophy", "Congenital myasthenic syndrome", "Corneal dystrophy", "Craniosynostosis", "Cushing syndrome", "Deafness", "Diabetes insipidus", "Diabetes mellitus", "Diamond-Blackfan anemia", "Disease variant", "Dwarfism", "Dyskeratosis congenita", "Dystonia", "Dystroglycanopathy", "Ectodermal dysplasia", "Ehlers-Danlos syndrome", "Elliptocytosis", "Emery-Dreifuss muscular dystrophy", "Epidermolysis bullosa", "Epilepsy", "FDA approved drug targets", "Fanconi anemia", "Gangliosidosis", "Gaucher disease", "Glaucoma", "Glutaricaciduria", "Glycogen storage disease", "Gout", "Hereditary hemolytic anemia", "Hereditary nonpolyposis colorectal cancer", "Hereditary spastic paraplegia", "Hermansky-Pudlak syndrome", "Hirschsprung disease", "Holoprosencephaly", "Hypogonadotropic hypogonadism", "Hypotrichosis", "Ichthyosis", "Intrahepatic cholestasis", "Joubert syndrome", "Kallmann syndrome", "Kartagener syndrome", "Leber congenital amaurosis", "Leigh syndrome", "Leukodystrophy", "Li-Fraumeni syndrome", "Limb-girdle muscular dystrophy", "Lissencephaly", "Long QT syndrome", "Mental retardation", "Metachromatic leukodystrophy", "Microphthalmia", "Mucopolysaccharidosis", "Myofibrillar myopathy", "Nemaline myopathy", "Nephronophthisis", "Neurodegeneration", "Neuronal ceroid lipofuscinosis", "Neuropathy", "Niemann-Pick disease", "Non-syndromic deafness", "Obesity", "Oncogene", "Osteogenesis imperfecta", "Palmoplantar keratoderma", "Parkinson disease", "Parkinsonism", "Peroxisome biogenesis disorder", "Peters anomaly", "Phenylketonuria", "Pontocerebellar hypoplasia", "Premature ovarian failure", "Primary ciliary dyskinesia", "Primary hypomagnesemia", "Primary microcephaly", "Primary mitochondrial disease", "Progressive external ophthalmoplegia", "Proto-oncogene", "Pyropoikilocytosis", "Retinitis pigmentosa", "Rhizomelic chondrodysplasia punctata", "SCID", "Schizophrenia", "Spinocerebellar ataxia", "Systemic lupus erythematosus", "Tumor suppressor", "Williams-Beuren syndrome", "Xeroderma pigmentosum", "Zellweger syndrome"], "available_proteins": ["AAAS", "AARS", "AARS2", "ABCB1", "ABCB7", "ABHD12", "ACAD9", "ACADM", "ACADVL", "ACAT1", "ACBD5", "ACLY", "ACO1", "ACO2", "ACOX1", "ACSL3", "ACSL4", "ACTN1", "ACTN2", "ACTN4", "ADA", "ADAR", "ADD3", "ADK", "ADNP", "ADPRHL2", "ADSL", "AFDN", "AFG3L2", "AGK", "AGL", "AGPS", "AHCY", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AKAP12", "AKAP13", "AKR1B1", "AKT2", "ALDH18A1", "ALDH2", "ALDH3A2", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDOA", "ALDOC", "ALG1", "ANAPC1", "ANK3", "ANKLE2", "ANLN", "ANXA1", "ANXA11", "ANXA2", "ANXA7", "AP1B1", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "APC", "APEX1", "APOL2", "APP", "APPL1", "APRT", "ARCN1", "ARHGDIA", "ARHGEF2", "ARID1A", "ARID3B", "ARIH1", "ARL2", "ARL3", "ARL6IP1", "ASAH1", "ASNS", "ASPH", "ATAD1", "ATAD3A", "ATIC", "ATP1A1", "ATP2A2", "ATP2B1", "ATP5A1", "ATP6AP1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1E1", "ATXN10", "AURKA", "B3GALT6", "B4GAT1", "BANF1", "BAZ1B", "BCAP31", "BCAS3", "BCLAF1", "BCS1L", "BICD2", "BIRC6", "BLMH", "BLVRB", "BMS1", "BPTF", "BRAT1", "BRD4", "BRI3BP", "BUB1B", "C19orf70", "C1QBP", "CAD", "CALM3", "CALR", "CAMK2G", "CANX", "CAPN1", "CARM1", "CARS", "CARS2", "CASK", "CASP3", "CASP6", "CASP7", "CASP8", "CAST", "CCAR1", "CCAR2", "CCDC22", "CCDC47", "CCDC6", "CCNB1", "CCT5", "CDC16", "CDC27", "CDC37", "CDC42", "CDC45", "CDC73", "CDK1", "CDK12", "CDK2", "CDK4", "CDK6", "CDX2", "CEP55", "CERS1", "CFL2", "CHAMP1", "CHD1", "CHD4", "CHEK2", "CHMP1A", "CHMP2B", "CHST14", "CISD2", "CIZ1", "CKB", "CKMT1A*", "CLCC1", "CLIC1", "CLN5", "CLPB", "CLPP", "CLPX", "CLTC", "CNNM4", "CNOT1", "COA3", "COA7", "COASY", "COG2", "COG6", "COLGALT1", "COMT", "COPA", "COPB2", "COQ8A", "COQ9", "COX15", "COX2", "COX4I1", "COX5A", "CPOX", "CPSF1", "CPT1A", "CPT2", "CRTAP", "CSDE1", "CSE1L", "CSNK2A2", "CSNK2B", "CSTB", "CTBP1", "CTNNB1", "CTNNBL1", "CTNND1", "CTSA", "CTSC", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CWF19L1", "CYB5R3", "CYC1", "CYP51A1", "DAD1", "DARS", "DARS2", "DBN1", "DCPS", "DCTN1", "DDOST", "DDRGK1", "DDX10", "DDX3X", "DDX41", "DDX5", "DDX6", "DEK", "DHCR24", "DHCR7", "DHFR", "DHPS", "DHX16", "DHX30", "DHX37", "DHX38", "DHX9", "DIABLO", "DIAPH1", "DIAPH3", "DICER1", "DIS3", "DKC1", "DLD", "DLST", "DNAAF5", "DNAJB1", "DNAJC2", "DNAJC3", "DNM1L", "DNM2", "DNMT1", "DOCK7", "DPF2", "DSG2", "DSP", "DST", "DYNC1H1", "DYNC1I2", "DYNLL1", "EARS2", "EBP", "ECE1", "ECHS1", "EDC3", "EEF1A2", "EEF2", "EFL1", "EFTUD2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2S2", "EIF3E", "EIF3F", "EIF3H", "EIF4A2", "EIF4A3", "EIF4E", "EIF4G1", "EIF4H", "EIF5A", "ELAC2", "ELP1", "ELP2", "ELP3", "EMC1", "EMD", "EMG1", "EML4", "ENO1", "EPB41", "EPB41L3", "EPHX1", "EPPK1", "EPRS", "EPS15", "ERAL1", "ERCC2", "ERCC3", "ERLIN1", "ERLIN2", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXOSC3", "EXOSC8", "EZR", "FABP5", "FADS2", "FAF1", "FAH", "FAM120A", "FAM3C", "FAM50A", "FANCI", "FAR1", "FARSB", "FASN", "FASTKD2", "FBXO7", "FDPS", "FDXR", "FECH", "FEN1", "FGFR1OP", "FH", "FHL1", "FIP1L1", "FKBP10", "FKBP14", "FKBP1A", "FKBP5", "FKBP8", "FLAD1", "FLNA", "FLNB", "FLNC", "FMR1", "FNTB", "FOXC1", "FOXRED1", "FSCN1", "FTO", "FTSJ1", "FUBP1", "FUCA1", "FUS", "G6PD", "GAA", "GALK1", "GALNT2", "GANAB", "GAPDH", "GARS", "GART", "GATAD2B", "GATB", "GATC", "GBA", "GBE1", "GCDH", "GCLM", "GDAP1", "GDI1", "GEMIN4", "GFM1", "GFPT1", "GGCX", "GIGYF2", "GLA", "GLB1", "GLDC", "GLMN", "GLO1", "GLRX5", "GLS", "GLUD1", "GM2A", "GMPPA", "GMPPB", "GMPS", "GNA13", "GNAI1", "GNAI3", "GNS", "GOT1", "GOT2", "GPHN", "GPI", "GPT2", "GRB2", "GSK3A", "GSK3B", "GSR", "GSS", "GSTM3", "GSTZ1", "GTF2I", "GTPBP3", "GUSB", "GYG1", "H4C1*", "HADH", "HADHA", "HADHB", "HCCS", "HCFC1", "HDAC2", "HELLS", "HEXA", "HEXB", "HIBCH", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLCS", "HMBS", "HMGA1", "HMGB3", "HMGCL", "HMOX1", "HNRNPA1", "HNRNPA2B1", "HNRNPDL", "HNRNPH2", "HNRNPK", "HNRNPU", "HOOK3", "HPRT1", "HSD17B10", "HSD17B4", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA2", "HSPA4", "HSPA8", "HSPA9", "HSPB1", "HSPD1", "HSPE1", "HSPH1", "HTT", "HUWE1", "HYOU1", "IARS", "IARS2", "IBA57", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IFT27", "IGBP1", "IGF2R", "ILF3", "ILK", "IMPDH1", "IMPDH2", "INF2", "IPO7", "IRS4", "ITGB1", "ITPA", "IVD", "JUP", "KARS", "KDM1A", "KDM3B", "KDSR", "KIF11", "KIF22", "KIF2A", "KIF2C", "KIF4A", "KIF5B", "KIFBP", "KLC2", "KTN1", "L2HGDH", "LAMP2", "LARP7", "LARS", "LARS2", "LAS1L", "LASP1", "LBR", "LDHA", "LDHB", "LDLR", "LEMD2", "LEMD3", "LGALS3", "LGALS3BP", "LGMN", "LIPA", "LMNA", "LMNB1", "LMNB2", "LNPK", "LONP1", "LPP", "LRBA", "LRPPRC", "LSS", "LTA4H", "LZTFL1", "M6PR", "MACF1", "MAD1L1", "MAD2L1", "MAGED2", "MAGT1", "MAP1B", "MAP2K1", "MAP2K2", "MAP2K3", "MAP4", "MAPK1", "MAPK14", "MARS", "MARS2", "MASTL", "MATR3", "MBNL1", "MBOAT7", "MCCC1", "MCCC2", "MCL1", "MCM2", "MCM3", "MCM5", "MCM7", "MCTS1", "MDC1", "MDH1", "MDH2", "MECP2", "MED1", "MESD", "MFN2", "MGME1", "MICU1", "MID1", "MIF", "MINPP1", "MIPEP", "MKI67", "MMAB", "MOGS", "MPDU1", "MPI", "MRE11", "MRPL12", "MRPL44", "MRPS2", "MRPS22", "MRPS23", "MRPS34", "MRPS7", "MSH2", "MSH6", "MSMO1", "MSN", "MSTO1", "MTA1", "MTOR", "MTPAP", "MTR", "MUT", "MYH10", "MYH14", "MYH9", "MYO6", "NAA10", "NAA15", "NAGLU", "NAMPT", "NANS", "NAXE", "NBN", "NCAPD2", "NCAPH", "NCSTN", "NDUFA10", "NDUFA11", "NDUFA13", "NDUFA2", "NDUFA4", "NDUFA9", "NDUFAF4", "NDUFB11", "NDUFB3", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS7", "NDUFS8", "NDUFV1", "NDUFV2", "NEFL", "NEK9", "NFKB1", "NHLRC2", "NHP2", "NISCH", "NME1", "NME2", "NNT", "NONO", "NOP10", "NOP56", "NPC1", "NPM1", "NSD2", "NSDHL", "NSUN2", "NSUN5", "NT5C2", "NUBPL", "NUCB2", "NUDT1", "NUMA1", "NUP107", "NUP133", "NUP155", "NUP160", "NUP188", "NUP205", "NUP214", "NUP37", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NXN", "OAT", "OCLN", "OGDH", "OGT", "OPA1", "OPA3", "OSGEP", "P3H1", "P4HA2", "P4HB", "PABPC1", "PABPN1", "PAF1", "PAFAH1B1", "PAK1", "PARK7", "PARN", "PARP1", "PARP2", "PBRM1", "PC", "PCBD1", "PCBP1", "PCCA", "PCCB", "PCM1", "PCNA", "PDAP1", "PDCD4", "PDE4DIP", "PDE6D", "PDHA1", "PDHB", "PDK3", "PDXK", "PEPD", "PEX14", "PEX19", "PEX5", "PFKM", "PFN1", "PGK1", "PGM1", "PHB", "PHF6", "PHF8", "PHGDH", "PICALM", "PIGK", "PIGS", "PIN1", "PINX1", "PISD", "PKM", "PLAA", "PLCG1", "PLD3", "PLEC", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLS3", "PMPCA", "PMPCB", "PNN", "PNP", "PNPT1", "POGZ", "POLA1", "POLD1", "POLE", "POLE3", "POLE4", "POLR1A", "POLR1B", "POLR1C", "POLR3A", "POP1", "POR", "PPA2", "PPIB", "PPIF", "PPOX", "PPP1CB", "PPP1R12A", "PPP2R1A", "PPP2R5D", "PPP5C", "PPP6C", "PPT1", "PQBP1", "PRC1", "PRCC", "PRDX2", "PRDX4", "PRDX5", "PREPL", "PRKACA", "PRKAG1", "PRKAR1A", "PRKCSH", "PRKDC", "PRKRA", "PRPF3", "PRPF31", "PRPF4", "PRPF6", "PRPF8", "PSAP", "PSAT1", "PSIP1", "PSMB1", "PSMB2", "PSMB4", "PSMB5", "PSMD12", "PSMD4", "PTDSS1", "PTRH2", "PUF60", "PUM1", "PURA", "PUS7", "PYCR1", "PYCR2", "PYGL", "QARS", "QDPR", "QKI", "QRSL1", "RAB10", "RAB11B", "RAB18", "RAB3GAP2", "RAB7A", "RAB8A", "RABEP1", "RAC1", "RAD21", "RAD23A", "RAD23B", "RANBP2", "RANBP3", "RAP1GDS1", "RAPGEF2", "RARS", "RARS2", "RBM10", "RBM12", "RBM28", "RBMX", "RDH11", "RDX", "REPS1", "RFC1", "RFC2", "RHEB", "RHOA", "RINT1", "RIPK1", "RNASEH2A", "RNASET2", "ROCK2", "RP2", "RPA2", "RPL10", "RPL11", "RPL13", "RPL15", "RPL18", "RPL21", "RPL22", "RPL27", "RPL3", "RPL35", "RPL35A", "RPL5", "RPN1", "RPS10", "RPS15", "RPS15A", "RPS17", "RPS19", "RPS2", "RPS23", "RPS24", "RPS28", "RPS3", "RPS6KA1", "RPS6KA3", "RPS7", "RPSA", "RRM1", "RRM2", "RTN2", "RTN4IP1", "SAMHD1", "SARS", "SART1", "SBDS", "SC5D", "SCARB2", "SCO1", "SCO2", "SCRIB", "SDHA", "SDHB", "SEC23A", "SEC23B", "SEC31A", "SEC61A1", "SEC63", "SEPT2", "SEPT9", "SERPINB6", "SERPINH1", "SET", "SETD2", "SF3B1", "SFPQ", "SFXN4", "SGPL1", "SH3GL1", "SHOC2", "SIGMAR1", "SKIV2L", "SKP2", "SLC16A1", "SLC19A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A20", "SLC25A22", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A4", "SLC2A1", "SLC33A1", "SLC3A2", "SLC9A3R1", "SMARCA4", "SMARCAD1", "SMARCC2", "SMARCE1", "SMC1A", "SMC3", "SMCHD1", "SMN1*", "SMPD4", "SMYD3", "SNAP29", "SND1", "SNRNP200", "SNRPE", "SNX3", "SOAT1", "SOD2", "SON", "SORD", "SPART", "SPECC1L", "SPEN", "SPR", "SPTAN1", "SPTBN2", "SPTLC1", "SPTLC2", "SQLE", "SQSTM1", "SRP54", "SRP72", "SRSF3", "SSB", "SSR4", "STAG1", "STAG2", "STAMBP", "STARD3", "STAT1", "STAT3", "STMN1", "STRAP", "STRN", "STT3A", "STUB1", "STX5", "SUCLA2", "SUCLG1", "SUZ12", "SV2A", "SYNE2", "TAF15", "TALDO1", "TARDBP", "TARS", "TARS2", "TBC1D4", "TBCD", "TBCE", "TCEA1", "TCOF1", "TDP2", "TECR", "TELO2", "TFAM", "TFG", "TFRC", "THOC2", "THOC6", "TIA1", "TIMM17A", "TIMM50", "TK1", "TKFC", "TKT", "TMCO1", "TMEM165", "TMEM199", "TMEM230", "TMEM43", "TMTC3", "TMX2", "TNPO3", "TOE1", "TOP1", "TOP2A", "TOP2B", "TOR1AIP1", "TP53", "TP53BP1", "TPD52", "TPI1", "TPM1", "TPM3", "TPM4", "TPP1", "TPR", "TPX2", "TRIM24", "TRIM25", "TRIM27", "TRIM33", "TRIP12", "TRIP13", "TRMT10C", "TSFM", "TSG101", "TTC19", "TUBB", "TUBB2A", "TUBB2B", "TUBB4A", "TUBB4B", "TUBB6", "TUBGCP2", "TUFM", "TWF1", "TXLNA", "TXNRD1", "TYMS", "U2AF1", "UBA1", "UBE2N", "UBE3A", "UBQLN4", "UBR5", "UBTF", "UFC1", "UFM1", "UGDH", "UGP2", "UMPS", "UNC119", "UNG", "UQCRB", "UQCRC2", "UQCRQ", "UROD", "USMG5", "USP9X", "UTP4", "VANGL1", "VAPB", "VARS1", "VARS2", "VCL", "VCP", "VIM", "VKORC1L1", "VPS33A", "VPS33B", "VPS35", "VRK1", "WARS", "WASHC4", "WBP2", "WDR1", "WDR36", "WDR5", "WFS1", "WIPI2", "WNK1", "XPNPEP3", "XPO1", "XRCC1", "XRCC5", 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a/protein_atlas_molecular_function/df_merge.tsv b/protein_atlas_molecular_function/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..3820ccc71de7546b2e3039ac1f4f78062ce5f837 --- /dev/null +++ b/protein_atlas_molecular_function/df_merge.tsv @@ -0,0 +1,6 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Receptor 10 33 3.274552657919778 0.0010582941319186 13.475728155339803 38.71116504854369 1.6655960679271569 0.1791616261110447 5.431559450288914 6.105192092581698 1.9169648296245776 0.2753083483896962 0.0871688139031856 0.1182182962859897 0.0958446637688343 0.082721917490672 0.5644975000974891 +Metalloprotease 7 26 2.989530637743916 0.0027940642501738 8.160194174757281 26.429611650485437 1.390302281711237 0.2661274848815638 3.192614043118206 1.543038499308978 1.1108461579919544 0.309446154241223 8.228897637207472e-05 0.0315268496209905 0.0023751027082345 7.125032306985868e-05 9.357969134051989e-05 +Protease 23 72 2.6917749696793902 0.007107288286922 20.788834951456312 82.44417475728156 1.1215350835872162 0.3507517256058336 6.07090559629836 8.079357013764625 1.4678877461728397 0.3691345771929886 0.003260109772397 0.3034250453076603 0.0729360657078838 0.0014131986706778 0.0003487710584489 +Host cell receptor for virus entry 2 14 2.3909157858198253 0.0168064073403533 4.509708737864078 15.157766990291265 0.7214109752050332 0.2527966464979699 2.499010078306418 1.9009100692398744 1.5211756979359785 0.2791170769282048 0.0407839133045401 0.0172375696548913 0.0625314301217693 0.0808776862517318 0.3363841302805421 +Oxidoreductase 38 153 2.1069291372357086 0.0351237225146623 36.64563106796116 165.7621359223301 0.5091071251362119 0.5527126631147542 14.160338956360992 12.210799107974529 1.1772957028589783 0.3900527505954884 1.5992772233771166e-06 0.0063949015215123 0.0021076579275208 4.277975413939871e-06 1.5333026371446126e-07 diff --git a/protein_atlas_molecular_function/metrics.json b/protein_atlas_molecular_function/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..6969d723aab12472423b77d1c76c8c64539482d5 --- /dev/null +++ b/protein_atlas_molecular_function/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2734, + "annotations_size": 96, + "title": "Average number of proteins per term", + "value": 34.020833333333336 +} \ No newline at end of file diff --git a/protein_atlas_molecular_function/paths.json b/protein_atlas_molecular_function/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..900814e133c2e0976b18728e9b66d83e141f7b97 --- /dev/null +++ b/protein_atlas_molecular_function/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/protein_atlas_molecular_function/fragment/C166/C166_val_log2fc"} \ No newline at end of file diff --git a/protein_atlas_molecular_function/result.tsv b/protein_atlas_molecular_function/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..96b6de316f7cd00fa508e5c8f84b343f730361f4 --- /dev/null +++ b/protein_atlas_molecular_function/result.tsv @@ -0,0 +1,26 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Receptor 0.6394534756660328 3.274552657919778 0.0010582941319186 0.0966543633609864 0.0112884707404651 33 Q8WTV0,Q14108,P24390,Q99720,Q14739,Q9NS69,P30825,O15118,O15173,Q9Y5M8 10 +Metalloprotease 0.656357487538981 2.9895306377439157 0.0027940642501738 0.235555301958193 0.0178820112011123 26 P09960,O75844,Q9UIQ6,O43847,P42892,Q7Z2K6,P55786 7 +Protease 0.4603520419233551 2.6917749696793902 0.007107288286922 0.495776610431395 0.0379055375302511 72 P09960,Q15005,P67812,Q7Z2K6,P55786,O14773,Q8TCT9,Q9UIQ6,Q99436,P42892,P53582,Q86TI2,P53634,Q99797,O43847,Q96K76,Q92643,P42785,O75976,O75844,Q5JRX3,Q92905,P28072 23 +Host cell receptor for virus entry 0.6905412044859436 2.3909157858198253 0.0168064073403533 0.8035066729248429 0.076829290698758 14 Q8WTV0,Q14108 2 +Monooxygenase 0.840108141114587 2.2475329268512176 0.0246059887005754 0.9085280073180771 0.0999953159441808 3 Q16850 1 +Oxidoreductase 0.361243584724681 2.1069291372357086 0.0351237225146623 0.967694506614475 0.1280726505029987 153 P36551,Q32P28,Q16850,Q9H845,P13073,P21912,Q8N0U8,Q8TED1,O75306,Q9BY49,P51648,Q15392,Q15067,Q99536,Q06136,Q8N4Q0,Q8IUF8,P16435,P00367,Q13363,Q8NBX0,P09601,P30043,Q14534,O15254,P43304,Q6UW02,Q53GQ0,O00625,P30519,P40939,Q15800,Q9UBM7,Q14739,Q9UHG3,P31350,O00767,Q16836 38 +Porin 0.8681318681318687 1.978886611067617 0.0478287740355178 0.9909500723075128 0.1563596535722503 4 P21796,P45880,Q9Y277 3 +Threonine protease 0.7778844571722308 1.9697904482087765 0.0488623917413282 0.9918461635166362 0.1563596535722503 3 Q99436 1 +Methyltransferase 0.4466931015091382 1.6358550839413812 0.1018699203241304 0.9999668436121496 0.2894122494077673 32 Q8N6R0,Q9H993,P21964,O60725,Q99707,Q8IYR2,P04818,O96028,Q6P2P2,Q7L592,Q86X55,Q08J23,Q5T280 13 +Acyltransferase 0.4535500682536152 1.5641183131804846 0.1177897860032215 0.9999940444779716 0.3141060960085908 29 Q8NCC3,Q9HCL2,Q96N66,O95260,P23786 5 +Aminopeptidase 0.604354585407708 1.4534520670752094 0.1460982790381324 0.9999997398898326 0.3596265330169413 11 P53582,Q9UIQ6,P55786 3 +Translocase 0.4747931156446585 1.35066497331553 0.1768027773377574 0.999999992266536 0.4126437692742927 18 Q8NBU5,Q9HD20,O75306,P16615,P08183 5 +Transferase 0.2872698298956162 1.0300046477775675 0.3030078237871765 0.9999999999999992 0.5691975455655336 293 Q13057,Q8NEB9,P27544,Q6YP21,P37268,Q99640,P14373,O60725,Q8NCH0,Q8IYR2,Q8TBX8,P23786,P46976,Q13546,Q96G23,P35790,P21964,Q99707,P48729,P55263,Q86X55,Q9BWD1,P36507,O14936,Q96EY8,P60604,Q13153,Q9HCL2,Q9BRR6,Q96N66,O95260,Q96L58,Q7LGA3,P48651,Q15120,Q96J02,P40939,P04062,P06737,P31751,Q05086,Q13555,Q13126,Q8NCC3,Q9BT22,Q6P2P2,P49356,Q7L592,O15269,P14618,P46977,Q16836,Q9Y5P6 53 +Glycosidase 0.4530499883044128 1.011412461546687 0.3118190593048187 0.9999999999999998 0.5691975455655336 15 O60502,Q9BTY2,P08236,P54802,P06865,P04062 6 +Kinase 0.3089906568268502 0.9466754503227848 0.3438041838366092 1.0 0.6112074379317498 89 Q13057,Q8NEB9,P35790,Q9BRR6,Q99640,Q8TBX8,P48729,P55263,Q15120,P14618,P36507,O14936,P31751,Q13555,Q13546 15 +Serine protease 0.5164005373663804 0.7191867796563691 0.4720258439326816 1.0 0.7266774309257322 8 O14773,Q86TI2 2 +Rotamase 0.3827981217241505 0.7113262896532594 0.4768820640450117 1.0 0.7266774309257322 19 P62942,Q9Y680,Q9NWM8 3 +Tumor antigen 0.411420204978033 0.5361313832481699 0.5918677518324913 1.0 0.7741821349104996 2 Q9UNF1 1 +Carboxypeptidase 0.479385956604697 0.4463282134408183 0.6553601792182826 1.0 0.8176363951655476 6 P42785 1 +Dioxygenase 0.360087137856078 0.4185801231670962 0.6755230187057817 1.0 0.8314129460994236 15 Q32P28,O00625 2 +Chloride channel 0.4561031082169181 0.3092407518944678 0.7571383965320131 1.0 0.8864059276472349 4 Q96S66 1 +Glycosyltransferase 0.3075189462995063 0.275578786718083 0.7828716047141719 1.0 0.90549004882603 26 Q13126,Q96L58,P46977,P04062,P06737 5 +Signal transduction inhibitor 0.3925302087147567 0.2629747485740099 0.7925700420150696 1.0 0.9057943337315082 3 P49841,P49840 2 +Serine/threonine-protein kinase 0.2744056312313628 0.2216538843503807 0.8245833320295812 1.0 0.929582017822834 47 Q99640,P48729,P11802,P31751,P36507,O14936,Q13153,Q13555,Q13546 9 +Ion channel 0.3404098775823312 0.0476737844702755 0.961976227301382 1.0 1.0 8 Q96S66,Q9UM00 2 diff --git a/protein_atlas_molecular_function/selections.json b/protein_atlas_molecular_function/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..65cb77f9ff570d2cde7dc365a85460c744896350 --- /dev/null +++ b/protein_atlas_molecular_function/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["Actin capping", "Actin-binding", "Activator", "Acyltransferase", "Allosteric enzyme", "Aminoacyl-tRNA synthetase", "Aminopeptidase", "Aminotransferase", "Antibiotic", "Antimicrobial", "Antioxidant", "Aspartyl protease", "Blood group antigen", "Calcium channel", "Calmodulin-binding", "Carboxypeptidase", "Chaperone", "Chloride channel", "Chromatin regulator", "Cyclin", "Cytokine", "DNA-binding", "DNA-directed DNA polymerase", "Decarboxylase", "Developmental protein", "Dioxygenase", "Dipeptidase", "Elongation factor", "Endonuclease", "Excision nuclease", "Exonuclease", "Fungicide", "GTPase activation", "Glycosidase", "Glycosyltransferase", "Growth factor", "Guanine-nucleotide releasing factor", "Helicase", "Heparin-binding", "Hormone", "Host cell receptor for virus entry", "Hydrolase", "IgE-binding protein", "Initiation factor", "Integrin", "Ion channel", "Isomerase", "Kinase", "Ligase", "Lyase", "Metalloenzyme inhibitor", "Metalloprotease", "Methyltransferase", "Mitogen", "Monooxygenase", "Motor protein", "Multifunctional enzyme", "Muscle protein", "Myosin", "Nuclease", "Nucleotidyltransferase", "Oxidoreductase", "Peroxidase", "Phospholipase A2 inhibitor", "Porin", "Prenyltransferase", "Protease", "Protease inhibitor", "Protein kinase inhibitor", "Protein phosphatase", "Protein phosphatase inhibitor", "Protein synthesis inhibitor", "RNA-binding", "Receptor", "Repressor", "Ribonucleoprotein", "Ribosomal protein", "Rotamase", "Serine esterase", "Serine protease", "Serine protease inhibitor", "Serine/threonine-protein kinase", "Signal transduction inhibitor", "Thiol protease", "Thiol protease inhibitor", "Threonine protease", "Topoisomerase", "Transducer", "Transferase", "Translational shunt", "Translocase", "Tumor antigen", "Tyrosine-protein kinase", "Voltage-gated channel", "rRNA-binding", "tRNA-binding"], "available_proteins": ["AARS", "AARS2", "AASDHPPT", "AASS", "ABCB1", "ABCE1", "ABCF1", "ABHD10", "ABHD12", "ABHD14B", "ABHD6", "ACAA2", "ACACA", "ACACB", "ACAD9", "ACADM", "ACADVL", "ACAT1", "ACAT2", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT8", "ACOT9", "ACOX1", "ACOX3", "ACP1", "ACP2", "ACP6", "ACSL1", "ACSL3", "ACSL4", "ACTN1", "ACTN2", "ACTN4", "ACTR2", "ACTR3", "ADA", "ADAR", "ADD1", "ADD3", "ADH5", "ADI1", "ADK", "ADNP", "ADPGK", "ADPRHL2", "ADSL", "ADSS", "AFG3L2", "AGK", "AGL", "AGPAT1", "AGPS", "AHCTF1", "AHCY", "AHCYL1", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AK1", "AK2", "AK4", "AK6", "AKAP12", "AKAP13", "AKAP8", "AKR1A1", "AKR1B1", "AKR7A2", "AKT2", "ALDH18A1", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALG1", "ALKBH5", "ANKHD1", "ANLN", "ANP32A", "ANP32B", "ANP32E", "ANXA1", "ANXA2", "APEH", "APEX1", "APP", "APRT", "AQR", "ARFGAP1", "ARHGAP17", "ARHGDIA", "ARHGEF1", "ARHGEF2", "ARID1A", "ARID3B", "ARIH1", "ARL8B", "ARMT1", "ARPC1A", "ARPC2", "ARPC3", "ARPC4", "ARPC5", "ASAH1", "ASCC3", "ASF1A", "ASNA1", "ASNS", "ASPH", "ATAD1", "ATE1", "ATIC", "ATL2", "ATP13A1", "ATP1A1", "ATP2A2", "ATP2B1", "ATP5B", "ATP6V1A", "ATP6V1B2", "ATP6V1E1", "AURKA", "B3GALT6", "B4GAT1", "BABAM1", "BAG2", "BAG4", "BAG5", "BAG6", "BANF1", "BAP18", "BAZ1B", "BCLAF1", "BCS1L", "BDH2", "BIRC6", "BLMH", "BLVRA", "BLVRB", "BPNT1", "BPTF", "BRD4", "BSG", "BTAF1", "BTF3", "BUB1", "BUB1B", "BZW1", "BZW2", "C12orf43", "CAD", "CALD1", "CALR", "CAMK2G", "CANX", "CAP1", "CAPN1", "CAPRIN1", "CAPZA1", "CAPZB", "CARHSP1", "CARM1", "CARS", "CARS2", "CASK", "CASP3", "CASP6", "CASP7", "CASP8", "CAST", "CBR1", "CBX3", "CBX8", "CCAR1", "CCAR2", "CCDC47", "CCNB1", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CDC37", "CDC42", "CDC5L", "CDIPT", "CDK1", "CDK12", "CDK2", "CDK4", "CDK6", "CDKN2AIP", "CDS2", "CDX2", "CEBPZ", "CELF1", "CEP55", "CERS1", "CERS2", "CFL1", "CFL2", "CGGBP1", "CHAC2", "CHCHD3", "CHD1", "CHD4", "CHEK2", "CHKA", "CHML", "CHMP1A", "CHORDC1", "CHRAC1", "CHST14", "CIRBP", "CKB", "CKMT1A*", "CLCC1", "CLGN", "CLIC1", "CLIC4", "CLPB", "CLPP", "CLPTM1", "CLPX", "CLUH", "CMPK1", "CNDP2", "CNN2", "CNN3", "CNOT1", "CNOT7", "CNOT9", "CNP", "COASY", "COLEC12", "COLGALT1", "COMT", "COPA", "COPS5", "COQ8A", "CORO1B", "CORO1C", "COTL1", "COX2", "COX4I1", "CPD", "CPNE1", "CPOX", "CPPED1", "CPSF1", "CPSF2", "CPSF3", "CPSF6", "CPSF7", "CPT1A", "CPT2", "CPVL", "CRYZ", "CS", "CSDE1", "CSK", "CSNK1A1", "CSNK2A2", "CSTB", "CSTF2", "CTBP1", "CTBP2", "CTDSPL2", "CTNNB1", "CTPS1", "CTPS2", "CTSA", "CTSC", "CUL5", "CXorf57", "CYB5R3", "CYC1", "CYFIP1", "CYP20A1", "CYP51A1", "DAGLB", "DAP3", "DARS", "DARS2", "DAZAP1", "DBN1", "DBNL", "DCAF1", "DCAF13", "DCAF7", "DCD", "DCP1A", "DCPS", "DCTD", "DCTPP1", "DCXR", "DDAH1", "DDB1", "DDI2", "DDT", "DDX1", "DDX10", "DDX17", "DDX18", "DDX20", "DDX21", "DDX23", "DDX24", "DDX28", "DDX39A", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX50", "DDX51", "DDX52", "DDX54", "DDX55", "DDX56", "DDX6", "DEK", "DENR", "DHCR24", "DHCR7", "DHFR", "DHPS", "DHRS7B", "DHX15", "DHX16", "DHX30", "DHX36", "DHX37", "DHX38", "DHX8", "DHX9", "DIAPH1", "DICER1", "DIEXF", "DIS3", "DKC1", "DLAT", "DLD", "DLST", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC2", "DNAJC3", "DNAJC7", "DNAJC8", "DNAJC9", "DNM1L", "DNM2", "DNMT1", "DNPH1", "DOCK7", "DOHH", "DOLPP1", "DPF2", "DPH2", "DPH5", "DPP3", "DPP9", "DPYSL2", "DRG1", "DRG2", "DST", "DSTN", "DTYMK", "DUSP3", "DUSP9", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNLL1", "DYNLL2", "EARS2", "EBP", "ECD", "ECE1", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "EDC3", "EDF1", "EEF1A2", "EEF1B2", "EEF1D", "EEF1G", "EEF2", "EFL1", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2D", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAC2", "ELAVL1", "ELP3", "EMD", "EMG1", "ENAH", "ENDOD1", "ENO1", "ENSA", "EPB41", "EPB41L2", "EPB41L3", "EPHX1", "EPHX2", "EPRS", "ERAL1", "ERAP1", "ERCC2", "ERCC3", "ERMP1", "ERO1A", "ERP44", "ESD", "ETFDH", "EWSR1", "EXO1", "EXOSC10", "EXOSC3", "EXOSC4", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC8", "F11R", "FADS2", "FAH", "FAHD1", "FAM120A", "FAM208A", "FAM213A", "FAM3C", "FANCI", "FAR1", "FARSA", "FARSB", "FASN", "FASTKD2", "FBL", "FDFT1", "FDPS", "FDXR", "FECH", "FEN1", "FH", "FHL1", "FHOD1", "FIP1L1", "FKBP10", "FKBP14", "FKBP1A", "FKBP3", "FKBP4", "FKBP5", "FKBP7", "FKBP8", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FMR1", "FN3KRP", "FNTB", "FOXC1", "FOXRED1", "FSCN1", "FTO", "FTSJ1", "FTSJ3", "FUBP1", "FUBP3", "FUCA1", "FUCA2", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GADD45GIP1", "GALK1", "GALNT2", "GALNT7", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GATAD2B", "GATB", "GATC", "GBA", "GBE1", "GBF1", "GCAT", "GCDH", "GCN1", "GDI1", "GDI2", "GDPD1", "GEMIN5", "GFM1", "GFPT1", "GGCT", "GGCX", "GGH", "GLA", "GLB1", "GLDC", "GLO1", "GLS", "GLUD1", "GLYR1", "GM2A", "GMDS", "GMFB", "GMPPB", "GMPS", "GNA13", "GNAI1", "GNAI2", "GNAI3", "GNPDA1", "GNS", "GOT1", "GOT2", "GPAM", "GPD2", "GPHN", "GPI", "GPKOW", "GPR89B", "GPT2", "GPX8", "GRHPR", "GRPEL1", "GRSF1", "GSK3A", "GSK3B", "GSR", "GSS", "GSTK1", "GSTM3", "GSTO1", "GSTZ1", "GTF2B", "GTF2F1", "GTF2F2", "GTF2I", "GTF3C1", "GTF3C3", "GUSB", "GYG1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACD3", "HADH", "HADHA", "HADHB", "HAT1", "HBS1L", "HCCS", "HCFC1", "HDAC2", "HDGF", "HDLBP", "HEATR1", "HECTD1", "HELLS", "HEXA", "HEXB", "HIBADH", "HIBCH", "HINT2", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLCS", "HLTF", "HM13", "HMBS", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMGCL", "HMGCS1", "HMOX1", "HMOX2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HP1BP3", "HPRT1", "HS2ST1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA14", "HSPA1B", "HSPA2", "HSPA4L", "HSPA8", "HSPA9", "HSPB1", "HSPD1", "HSPE1", "HTATSF1", "HUWE1", "HYOU1", "IARS", "IARS2", "IBA57", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDI1", "IFIT5", "IGBP1", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "ILF2", "ILF3", "ILK", "ILKAP", "ILVBL", "IMP3", "IMPDH1", "IMPDH2", "INA", "INF2", "IQGAP1", "IRS4", "ISYNA1", "ITCH", "ITGB1", "ITPA", "IVD", "KARS", "KAT7", "KDELC2", "KDELR1", "KDM1A", "KDM1B", "KDM2A", "KDM3B", "KDSR", "KHDRBS1", "KHDRBS3", "KHSRP", "KIF11", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF3A", "KIF4A", "KIF5B", "KIFBP", "KIFC1", "KLC1", "KLC2", "KLC4", "KYAT3", "L2HGDH", "LAMP1", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LASP1", "LBR", "LDHA", "LDHB", "LDLR", "LEMD3", "LGALS3", "LGMN", "LIG1", "LIG3", "LIMA1", "LIPA", "LNPEP", "LNPK", "LONP1", "LPCAT1", "LPP", "LRPAP1", "LRPPRC", "LSM6", "LSM7", "LSM8", "LSS", "LTA4H", "LYAR", "LYPLA1", "M6PR", "MACF1", "MAGED2", "MAP1S", "MAP2K1", "MAP2K2", "MAP2K3", "MAPK1", "MAPK14", "MARC1", "MARCKS", "MARS", "MARS2", "MASTL", "MAT2A", "MATR3", "MBNL1", "MBOAT7", "MCAT", "MCCC1", "MCCC2", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCTS1", "MCU", "MDH1", "MDH2", "MDN1", "ME2", "MEAF6", "MECP2", "MED1", "MED24", "MESD", "METAP1", "METTL13", "MFN1", "MFN2", "MGEA5", "MGME1", "MGST2", "MGST3", "MID1", "MIF", "MINPP1", "MIPEP", "MKI67", "MMAB", "MMS19", "MOGS", "MORF4L1", "MOV10", "MPHOSPH10", "MPI", "MPRIP", "MPST", "MRC2", "MRE11", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL14", "MRPL15", "MRPL17", "MRPL19", "MRPL20", "MRPL21", "MRPL37", "MRPL38", "MRPL39", "MRPL40", "MRPL43", "MRPL44", "MRPL47", "MRPL48", "MRPL49", "MRPL50", "MRPL53", "MRPL58", "MRPL9", "MRPS15", "MRPS17", "MRPS2", "MRPS22", "MRPS23", "MRPS25", "MRPS27", "MRPS30", "MRPS31", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRPS9", "MSH2", "MSH3", "MSH6", "MSI1", "MSMO1", "MTA1", "MTA2", "MTAP", "MTHFD1L", "MTHFD2", "MTOR", "MTPAP", "MTR", "MUT", "MYBBP1A", "MYG1", "MYH10", "MYH14", "MYH9", "MYL6", "MYO1B", "MYO1D", "MYO6", "NAA10", "NAA15", "NAA40", "NAA50", "NADK2", "NAF1", "NAGK", "NAGLU", "NAMPT", "NANS", "NAP1L4", "NARS", "NAT10", "NAXE", "NCBP2", "NCL", "NCOA5", "NDUFAF4", "NDUFAF7", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS7", "NDUFS8", "NDUFV1", "NDUFV2", "NEK9", "NELFA", "NELFCD", "NELFE", "NES", "NFKB1", "NFS1", "NHP2", "NIFK", "NIP7", "NISCH", "NKRF", "NKTR", "NLN", "NME1", "NME2", "NMT1", "NNT", "NOC2L", "NOL11", "NOL6", "NOL8", "NOL9", "NONO", "NOP10", "NOP2", "NOP56", "NOP58", "NOP9", "NOSIP", "NPC1", "NPEPPS", "NPLOC4", "NPM1", "NRDC", "NSA2", "NSD2", "NSDHL", "NSF", "NSUN2", "NSUN5", "NT5C2", "NT5C3B", "NT5DC1", "NT5DC2", "NTMT1", "NTPCR", "NUCB1", "NUCB2", "NUDCD1", "NUDT1", "NUDT21", "NUDT5", "NUDT9", "NUFIP2", "NUP153", "NUP98", "NXF1", "NXN", "OAT", "OGDH", "OGT", "OLA1", "OPA1", "OSGEP", "OTUB1", "P3H1", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PAFAH1B1", "PAFAH1B3", "PAICS", "PAK1", "PAK1IP1", "PAK2", "PALLD", "PANK4", "PAPSS1", "PARK7", "PARN", "PARP1", "PARP2", "PASK", "PBK", "PBRM1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCK2", "PCMT1", "PCNA", "PCYOX1", "PDCD4", "PDCL3", "PDE12", "PDHA1", "PDHB", "PDIA3", "PDIA4", "PDIA6", "PDK3", "PDLIM7", "PDXK", "PEBP1", "PECR", "PELO", "PELP1", "PEPD", "PFAS", "PFDN2", "PFDN4", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGP", "PGRMC1", "PGRMC2", "PHB2", "PHF5A", "PHF6", "PHF8", "PHGDH", "PI4K2A", "PI4KB", "PIGK", "PIK3C3", "PIN1", "PIN4", "PIP4K2C", "PIR", "PISD", "PITHD1", "PITRM1", "PKM", "PKMYT1", "PKN1", "PKN2", "PLA2G15", "PLAA", "PLBD2", "PLCG1", "PLD3", "PLD6", "PLEC", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLS3", "PMPCB", "PNN", "PNO1", "PNP", "PNPLA8", "PNPT1", "POFUT1", "POGZ", "POLA1", "POLD1", "POLDIP3", "POLE", "POLE3", "POLE4", "POLR1A", "POLR1B", "POLR2B", "POLR2G", "POLR3A", "POLRMT", "PON2", "POP1", "POR", "PPA1", "PPA2", "PPAT", "PPIB", "PPID", "PPIE", "PPIF", "PPIH", "PPIL1", "PPIL4", "PPM1G", "PPME1", "PPOX", "PPP1CA", "PPP1CB", "PPP1R10", "PPP1R8", "PPP5C", "PPP6C", "PPT1", "PPT2", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PREP", "PREPL", "PRIM1", "PRIM2", "PRKACA", "PRKDC", "PRKRA", "PRMT1", "PRMT3", "PRMT5", "PRMT9", "PRPF19", "PRPF31", "PRPF4B", "PRPF8", "PRPS2", "PSAT1", "PSIP1", "PSMB5", "PSMB6", "PSMB7", "PSMD10", "PSMD14", "PSME4", "PSMG1", "PSMG3", "PSPC1", "PTBP1", "PTBP2", "PTCD3", "PTDSS1", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK7", "PTPA", "PTPN1", "PTRH2", "PTRHD1", "PUF60", "PUM1", "PUM3", "PURA", "PUS7", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QDPR", "QKI", "QRSL1", "RAB10", "RAB11B", "RAB18", "RAB1A", "RAB1B", "RAB3GAP1", "RAB3GAP2", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RABGAP1", "RAC1", "RACK1", "RAD21", "RAD50", "RAD9A", "RALA", "RALB", "RALY", "RANBP1", "RANBP2", "RANGAP1", "RAP1GDS1", "RAPGEF2", "RARS", "RARS2", "RAVER1", "RBBP5", "RBBP6", "RBM10", "RBM12", "RBM12B", "RBM14", "RBM17", "RBM19", "RBM22", "RBM25", "RBM26", "RBM27", "RBM28", "RBM3", "RBM34", "RBM39", "RBM4", "RBM42", "RBM4B", "RBM5", "RBM8A", "RBMX", "RBMXL1", "RBPMS", "RCC1", "RCC2", "RDH11", "RDH13", "RDH14", "RDX", "RECQL", "RETSAT", "REXO2", "REXO4", "RFC1", "RFC3", "RFX1", "RHOA", "RHOT1", "RIC8A", "RIDA", "RIOX2", "RIPK1", "RNASEH2A", "RNASET2", "RNF14", "RNF20", "RNF219", "RNF40", "RNPEP", "RNPS1", "ROCK2", "RP2", "RPA1", "RPA2", "RPAP1", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPP30", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RRM1", "RRM2", "RRP1B", "RRP8", "RSF1", "RTCB", "RTRAF", "RUVBL1", "RUVBL2", "SACM1L", "SAE1", "SAFB", "SAFB2", "SAMHD1", "SAP130", "SAP18", "SARNP", "SARS", "SARS2", "SART3", "SC5D", "SCAF1", "SCAF4", "SCARB1", "SCARB2", "SCCPDH", "SCD", "SCML2", "SCO1", "SCO2", "SCP2", "SCPEP1", "SCRIB", "SDHA", "SDHB", "SEC11A", "SEC61A1", "SEC63", "SENP3", "SEPHS1", "SERBP1", "SERPINB6", "SERPINH1", "SET", "SETD2", "SF1", "SF3B1", "SF3B4", "SF3B6", "SFPQ", "SFSWAP", "SGPL1", "SGTA", "SHMT1", "SHMT2", "SHTN1", "SIGMAR1", "SIRT1", "SKIV2L", "SKIV2L2", "SLC1A5", "SLC27A4", "SLC7A1", "SLFN11", "SLIRP", "SLIT2", "SLK", "SLTM", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCC1", "SMARCC2", "SMARCE1", "SMCHD1", "SMN1*", "SMPD4", "SMYD3", "SMYD4", "SND1", "SNRNP200", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPC", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNU13", "SOAT1", "SOD2", "SON", "SORD", "SORT1", "SPCS2", "SPEN", "SPOUT1", "SPPL2A", "SPR", "SPTAN1", "SPTBN1", "SPTBN2", "SPTLC1", "SPTLC2", "SQLE", "SRM", "SRP14", "SRP54", "SRP68", "SRP72", "SRP9", "SRPK1", "SRPRA", "SRPRB", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF3", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSRP1", "STAMBP", "STAT1", "STAT3", "STAU1", "STAU2", "STK4", "STMN1", "STRBP", "STRN", "STT3A", "STUB1", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUPT5H", "SUPT6H", "SUPV3L1", "SURF6", "SUZ12", "SYNCRIP", "SYNE2", "TAF15", "TALDO1", "TAMM41", "TARDBP", "TARS", "TARS2", "TBC1D10B", "TBC1D13", "TBC1D15", "TBC1D4", "TBC1D9B", "TBCA", "TBCC", "TBCD", "TBCE", "TCEA1", "TCERG1", "TCP1", "TDP2", "TDRKH", "TECR", "TERF2IP", "TFAM", "TFCP2", "TFRC", "THOC1", "THOC2", "THOC3", "THOC6", "THOP1", "THRAP3", "THUMPD3", "TIA1", "TIAL1", "TIGAR", "TIMM10", "TIMM50", "TIMM8B", "TJP1", "TK1", "TKFC", "TKT", "TMCO1", "TMEM109", "TMOD1", "TMOD3", "TMTC3", "TMX3", "TOMM22", "TOMM34", "TOMM40", "TOP1", "TOP2A", "TOP2B", "TOX4", "TP53", "TP53BP1", "TPI1", "TPM1", "TPM3", "TPM4", "TPP1", "TPP2", "TRA2A", "TRA2B", "TRAP1", "TRIM21", "TRIM24", "TRIM25", "TRIM26", "TRIM27", "TRIM28", "TRIM33", "TRIM35", "TRIP12", "TRIR", "TRMT10C", "TRMT1L", "TROVE2", "TSFM", "TSN", "TSNAX", "TTF2", "TTYH3", "TUFM", "TWF1", "TWF2", "TXNDC12", "TXNRD1", "TYMS", "U2AF1", "U2AF2", "U2SURP", "UAP1", "UBA1", "UBA2", "UBA3", "UBA6", "UBE2G2", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2O", "UBE2S", "UBE3A", "UBE4B", "UBLCP1", "UBR4", "UBR5", "UBTF", "UCHL5", "UFL1", "UGDH", "UGGT1", "UGP2", "UHRF1", "UMPS", "UNC45A", "UNG", "UPF1", "UROD", "USP10", "USP11", "USP14", "USP15", "USP47", "USP48", "USP5", "USP7", "USP9X", "UTP3", "UTRN", "VARS1", "VARS2", "VAT1", "VBP1", "VCL", "VCP", "VDAC1", "VDAC2", "VDAC3", "VIRMA", "VKORC1L1", "VPS4B", "VRK1", "WARS", "WDHD1", "WDR1", "WDR18", "WDR43", "WDR5", "WNK1", "WTAP", "XPNPEP1", "XPNPEP3", "XPO1", "XPO5", "XPOT", "XRCC5", "XRCC6", "XRN2", "YARS", "YARS2", "YBX1", "YBX3", "YEATS4", "YKT6", "YLPM1", "YME1L1", "YTHDC1", "YTHDC2", "YTHDF2", "YTHDF3", "ZADH2", "ZC3H14", "ZC3H7A", "ZC3HAV1", "ZCCHC3", "ZFR", "ZMPSTE24", "ZNF207", "ZNF24", "ZNF281", "ZNF318", "ZNF326", "ZNF638"], "leading_proteins": ["ABCB1", "ACAD9", "ACAT2", "ACOX1", "ACOX3", "ADK", "ADPGK", "AKT2", "ALDH3A2", "ALG1", "ARMT1", "ATAD1", "ATE1", "ATP13A1", "ATP2A2", "B3GALT6", "BLVRB", "CAMK2G", "CARM1", "CASK", "CDK4", "CERS1", "CERS2", "CHKA", "CHST14", "CLCC1", "COASY", "COMT", "COPS5", "COX4I1", "CPD", "CPOX", "CPT2", "CSNK1A1", "CTBP1", "CTSC", "CYP20A1", "CYP51A1", "DHCR24", "DHCR7", "DPP9", "ECE1", "ERMP1", "FDFT1", "FKBP14", "FKBP1A", "FKBP7", "FNTB", "FUCA2", "GBA", "GLUD1", "GMPPB", "GPAM", "GPD2", "GPX8", "GSK3A", "GSK3B", "GUSB", "GYG1", "HADH", "HADHA", "HEXA", "HM13", "HMOX1", "HMOX2", "HS2ST1", "HSD17B12", "ICMT", "ITCH", "KDELR1", "KDSR", "KYAT3", "LBR", "LNPEP", "LTA4H", "MAGED2", "MAP2K2", "MBOAT7", "METAP1", "METTL13", "MGEA5", "MIPEP", "MMAB", "MSMO1", "MTAP", "MTR", "NAGLU", "NDUFAF7", "NDUFS2", "NPC1", "NPEPPS", "NRDC", "NSD2", "NSUN2", "P3H1", "PAK1", "PCYOX1", "PDK3", "PECR", "PGRMC2", "PIGK", "PIK3C3", "PIP4K2C", "PIR", "PITRM1", "PKM", "PKMYT1", "PLA2G15", "POR", "PRCP", "PRMT9", "PSMB6", "PSMB7", "PTDSS1", "PYGL", "RIOX2", "RIPK1", "RRM2", "SCARB1", "SCARB2", "SCCPDH", "SCD", "SDHB", "SEC11A", "SIGMAR1", "SLC7A1", "SMYD4", "SPCS2", "SPOUT1", "SPTLC1", "SQLE", "SRPRB", "STT3A", "TMCO1", "TOMM22", "TPP1", "TRIM27", "TYMS", "UBE2G2", "UBE3A", "USP47", "VAT1", "VDAC1", "VDAC2", "VDAC3", "VKORC1L1", "ZADH2", "ZMPSTE24"]} \ No newline at end of file diff --git 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sha256:af83010418b9afbc71ca0e1a956e846be7e853adaa903b49c291d9d03aafb8b8 +size 149070 diff --git a/protein_atlas_protein_class/basic/plot_5.png b/protein_atlas_protein_class/basic/plot_5.png new file mode 100644 index 0000000000000000000000000000000000000000..9387bb2a469e10293bd506b7a95ed094f96ce134 --- /dev/null +++ b/protein_atlas_protein_class/basic/plot_5.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:1e6cc0699f66f06977bf9c00b521f16ec365cbc1b4daec888d4e314b614d0793 +size 142856 diff --git a/protein_atlas_protein_class/consensus.joblib b/protein_atlas_protein_class/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..1378d0b87ace202ca2fb52f9dad9186a50f06948 --- /dev/null +++ b/protein_atlas_protein_class/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:7396b97c791b2a7eac6e0fb050897a0f51e3c8333fbfe83222268009a67c4ab9 +size 81980 diff --git a/protein_atlas_protein_class/df_merge.tsv b/protein_atlas_protein_class/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..f7cbc89258aa2f3a0d3ec7fc0629a7f87be79651 --- /dev/null +++ b/protein_atlas_protein_class/df_merge.tsv @@ -0,0 +1,3 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Predicted membrane proteins 220 461 7.707877745592931 1.2792720555141203e-14 204.61650485436897 563.8058252427185 3.080866334016093 0.3028099075873978 81.17076282318972 73.52280648113661 4.068861305085399 0.4187410497068249 6.46511308861896e-28 4.2508318356866075e-10 2.9796242481244755e-16 2.4624445144749597e-23 1.402618960371726e-27 +Transporters 115 326 3.4158101617975194 0.0006359256305452 108.9004854368932 367.3009708737864 1.469396346451591 0.4764419032567517 40.40141182476491 35.10022679965902 2.352674986871393 0.4490473364946538 1.8199884867914447e-11 0.0318727848003628 0.0005540441044125 2.53797120974914e-09 8.608147733563816e-12 diff --git a/protein_atlas_protein_class/metrics.json b/protein_atlas_protein_class/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..8792eaea184b15da283a98d646c61521ea0b28a7 --- /dev/null +++ b/protein_atlas_protein_class/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2734, + "annotations_size": 20, + "title": "Average number of proteins per term", + "value": 445.45 +} \ No newline at end of file diff --git a/protein_atlas_protein_class/paths.json b/protein_atlas_protein_class/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..1de991cf905ce6a5ee9c398acb070b48cf728f16 --- /dev/null +++ b/protein_atlas_protein_class/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/protein_atlas_protein_class/fragment/C166/C166_val_log2fc"} \ No newline at end of file diff --git a/protein_atlas_protein_class/result.tsv b/protein_atlas_protein_class/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..4170966dd8c2b9c287498e1d0535cb6a6923c66e --- /dev/null +++ b/protein_atlas_protein_class/result.tsv @@ -0,0 +1,8 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Predicted membrane proteins 0.6301677720718358 7.707877745592931 1.2792720555141203e-14 2.5587441110279296e-13 1.2793720555141206e-13 461 Q99595,Q9Y619,Q9NZ01,Q16850,P37268,O60830,Q9BQE5,Q9C0H2,O60725,Q12981,Q8IYR2,Q9NS69,O75306,Q07820,Q9UBG0,Q9P260,Q8NAN2,Q9H1E5,O43169,O00461,Q9NX00,Q13505,Q5VW38,Q9Y487,Q9NPR9,Q86XL3,Q96AQ8,O43674,Q93050,Q8WTV0,Q9NQC3,Q96G23,Q14108,Q15392,P43307,Q70HW3,Q06136,Q9H061,Q6UW68,P60228,P42892,Q9HD45,Q9NZ45,Q3SXM5,Q8N511,Q9UDW1,Q9Y282,Q15125,Q15070,Q9HCL2,Q96N66,Q99720,O75964,O95197,Q9HD20,P30825,Q9UBX3,P62942,Q6UW02,Q8TB61,Q92804,P30519,O96005,P08183,O43676,Q8NCC3,Q9UDX5,Q9P2W9,Q14739,O75844,Q5BJF2,Q9NZJ7,O43772,Q9BTX1,P46977,Q8WY22,O00767,Q96RQ1,O75381,Q9HC07,Q9Y2R0,P27544,Q8IXU6,P24390,O60637,Q8NCH0,Q96HA9,Q9UBU6,Q96A57,O15118,Q8IYS2,Q8TAA9,Q9NR77,P67812,O95772,Q7Z2K6,Q9H4I3,Q02978,P16615,P51648,Q567V2,Q96PC5,Q9BUN8,Q96A33,Q9BXK5,Q8TCT9,Q5SNT2,Q9UIQ6,P16435,Q15629,Q8NBX0,P09601,Q8NE00,P05067,O14936,Q07065,Q13190,Q14534,Q86Y39,Q96KA5,O15173,Q8NCG7,Q9Y5M8,Q96A26,O43657,O43760,Q05086,Q15800,Q9UBM7,Q9H6K4,P51809,P51572,Q9UEU0,P36551,O00264,P13073,O95168,Q8N0U8,P41440,Q9BSK2,Q8IV08,P01889,Q9NX40,Q9P035,P11166,O95470,Q96SK2,Q92896,Q70UQ0,O76024,Q15631,Q86UE4,P38435,Q99442,Q9UM00,P53634,O95202,Q6P4A7,Q8NBU5,Q96GC9,P48651,A1L0T0,Q53GQ0,P57088,Q13555,Q8N1F7,Q99523,Q9BT22,Q13423,O14925,O15126,Q9H3K2,O15269,P31350,Q8N2A8,P50402,Q15005,Q8TB36,Q99640,Q9Y3E0,O75027,O75845,P51790,Q7KZN9,Q9Y679,Q8IWA4,Q00765,Q969V3,P28288,Q9NX14,Q9HCU5,O60488,Q9NVA1,Q8NE01,Q6NUQ4,O15127,O94919,O75298,O15400,Q96IX5,Q16625,P12236,Q9P0J0,Q8IZA0,Q86YN1,P57105,P27105,P08195,Q9NTJ5,Q92643,O75976,O95864,Q52LJ0,Q8TCT8,Q96S66,Q8WVC6,O15258,Q9Y320,Q9H3N1,Q86Y82 220 +Transporters 0.4031504691913463 3.4158101617975194 0.0006359256305452 0.0126419687256313 0.0042395042036351 326 Q9Y619,Q9C0H2,P45880,Q9H2D1,P40855,Q5VW38,Q99567,Q93050,Q8WTV0,Q14108,Q70HW3,P14635,O15260,Q9H061,Q6UW68,Q96AG4,P05023,P57740,Q9UBV2,Q9H9B4,Q8N511,O00429,Q15070,Q96N66,Q99720,Q9HD20,P30825,O00571,Q9UBX3,P62942,Q9Y6C9,Q9Y3B3,Q8TB61,Q9NRG9,O96005,Q8NHH9,P08183,P53985,O75844,Q5BJF2,Q9NZJ7,O43772,Q9BTX1,P46977,P07602,Q8WY22,O75381,Q9HC07,Q8IXU6,P24390,O60637,Q9UBU6,Q96A57,O15118,Q8TAA9,Q9NR77,O43865,Q02978,P16615,Q96PC5,Q9BUN8,Q96A33,Q15629,Q8TEX9,Q8NE00,P05067,Q07065,Q13190,Q9ULJ7,Q9NQZ5,Q9BRK5,O43681,P51572,Q9UEU0,P13073,P21912,P41440,Q9BSK2,Q96P70,P11166,O76024,Q99442,Q9UM00,O95202,Q6P4A7,Q96GC9,P57088,O60313,Q13555,Q8N1F7,Q8NFH4,Q99523,O96008,O15126,O75027,Q8IYU8,Q8IWA4,Q9NPI6,Q969V3,P28288,Q9HCU5,Q8NE01,O15127,Q16625,P50570,P12236,P57105,P27105,P08195,Q8TCT8,Q96S66,Q15287,O15258,Q9Y320,Q9H3N1 115 +Metabolic proteins 0.2891430009684277 1.4223920137673418 0.1549124802590558 0.9654829428371638 0.3477397847210062 765 P09960,Q8NEB9,Q16850,P37268,O60725,O75306,P23786,Q9H2D1,Q9H773,O43924,Q9Y487,P55786,Q93050,Q8WTV0,Q96G23,Q15392,Q70HW3,Q06136,Q15165,O14949,Q8N4Q0,P55263,P00367,P83881,Q9NPH0,P07099,Q96EY8,P60604,Q9UDW1,Q15125,Q9HCL2,Q9BRR6,Q96N66,O75964,O15254,O95260,Q9NWM8,P30825,Q9UBX3,P62942,Q8TB61,P30519,P16930,P31751,P08183,O43676,Q13126,Q8NCC3,Q14739,O75844,O43772,Q13011,P48449,Q9BTX1,Q9UHG3,P46977,P07602,O00767,Q9H7Z7,P27544,Q8NCH0,O15118,Q9BY49,P08236,P67812,O43865,Q02978,P16615,P51648,Q15067,P21964,P16435,Q13363,Q8NBX0,P09601,Q9BWD1,O14936,Q14534,Q9NQZ5,Q86Y39,O60502,Q96L58,Q7LGA3,Q8NCG7,P04062,Q05086,Q15800,Q9UBM7,Q6P2P2,P49356,P14618,P06737,Q16836,P51572,P36551,Q6YP21,P50897,P13073,O95168,P21912,P41440,P35606,O96000,Q9Y6M9,Q8IV08,Q9P035,Q13546,P11166,P35790,O95470,Q99707,Q9Y680,P30043,P54802,Q10713,P53634,P43304,P48651,Q15120,Q53GQ0,Q96K76,Q96J02,P40939,O14734,Q13555,Q8N1F7,Q8NFH4,Q9BT22,Q13423,O15269,P31350,Q8N2A8,Q9Y5P6,Q13057,Q15005,Q99956,Q9H845,Q99640,Q8TBX8,Q8TED1,O75845,P17812 142 +Potential drug targets 0.2778984731402049 0.503266266578408 0.6147770800979615 0.9999999948210422 0.8782529715685164 429 Q9HC07,P36551,Q32P28,P50897,P37268,P13073,P14373,Q8NCH0,P21912,O75306,O15118,Q9H2D1,Q8TAA9,P08236,Q8IV08,Q02978,P51648,Q13546,Q96PC5,P11166,Q96A33,Q14108,Q15392,Q15067,Q70HW3,Q06136,O95470,Q9H0R6,Q9H061,P55263,P16435,P00367,O76024,P42892,P09601,P54802,Q10713,O14936,P07099,Q8N511,Q96EY8,Q9UM00,Q15125,P53634,Q96N66,Q6P4A7,Q96L58,P48651,Q9NWM8,Q15120,P28070,Q96J02,P40939,P04062,P16930,P31751,Q05086,P06737,O60313,Q13555,Q13126,Q15800,Q8N1F7,Q8NFH4,Q99523,Q9UBM7,Q14739,O75844,O43772,Q7L592,P48449,P51572,P46977,P07602,O75381 75 +CD markers 0.3711422198190345 0.3061002641156177 0.7595283068371359 0.999999999999582 1.0 12 P08195,P08183 2 +FDA approved drug targets 0.2458174744924398 0.1247124232088855 0.900751221892305 1.0 1.0 107 Q16850,Q8N0U8,P23786,P16615,Q16637,P21964,Q99707,P30043,P36507,P05067,P00813,P38435,Q14534,Q99720,P49721,P62942,P20618,Q13423,P49356,P31350,Q16836 21 +Human disease related genes 0.2469559865336699 0.099989766816356 0.9203524496267312 1.0 1.0 799 Q9BQE5,Q9H9C1,O75306,P23786,O43924,Q9Y487,Q86XL3,Q14108,Q15392,Q70HW3,Q06136,O14949,Q9H061,P55263,P00367,P42892,P07099,Q8N511,Q96EY8,Q15125,Q96N66,Q99720,Q9NWM8,Q9UBX3,P16930,P31751,P08183,O43676,O14979,Q14739,O75844,O43772,P48449,P46977,P07602,O75381,Q8WWV3,Q9H7Z7,Q9HC07,Q32P28,P27544,Q8NCH0,O15118,Q8TAA9,P08236,Q9NR77,P16615,P51648,P35637,Q15067,P21964,Q9H0R6,P16435,Q13363,P09601,P55795,P05067,O14936,O75503,P08670,Q9NQZ5,Q86Y39,P22626,Q16204,Q96L58,P38159,P04062,Q05086,Q15800,Q9UBM7,Q8N0X7,Q9H6K4,Q01105,P06737,Q16836,P51572,Q9H267,Q15233,P36551,P50897,P21912,P25054,P35606,O96000,Q9Y6M9,Q8IV08,P01889,P61978,P11166,O95470,Q99707,O76024,P54802,Q10713,P38435,Q9UM00,Q8TD16,P53634,O95202,Q6P4A7,Q8NBU5,P48651,Q15120,Q6NUQ1,Q96J02,P40939,O60313,Q13555,Q8N1F7,Q8NFH4,Q9BT22,Q9NVI7,Q9H0B6,Q13423,O15269,P43243,Q9Y5P6,P50402,P31483,Q13057,Q8IWS0,Q8TB36,Q9H845,O75027,P98175,P07196,O75845,P17812,P46976,Q7KZN9,Q96EK5,Q9UHX1,P61960,O14773,P28288,Q16637,Q9NX14,O60488,P36507,P09651,P00813,Q13153,P49366,O75298,Q9HCC0,Q96IX5,Q99797,Q16625,P50570,P49770 150 diff --git a/protein_atlas_protein_class/selections.json b/protein_atlas_protein_class/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..f2ecce7fe14120fc521d3cbef74e9941b11d340c --- /dev/null +++ b/protein_atlas_protein_class/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["Blood group antigen proteins", "CD markers", "Cancer-related genes", "Candidate cardiovascular disease genes", "Citric acid cycle related proteins", "Disease related genes", "Enzymes", "FDA approved drug targets", "Human disease related genes", "Metabolic proteins", "Plasma proteins", "Potential drug targets", "Predicted intracellular proteins", "Predicted membrane proteins", "Predicted secreted proteins", "RAS pathway related proteins", "RNA polymerase related proteins", "Ribosomal proteins", "Transcription factors", "Transporters"], "available_proteins": ["AAAS", "AAR2", "AARS", "AARS2", "AARSD1", "AASDHPPT", "AASS", "AATF", "ABCB1", "ABCB10", "ABCB7", "ABCD3", "ABCE1", "ABCF1", "ABCF2", "ABHD10", "ABHD12", "ABHD14B", "ABHD6", "ACAA2", "ACACA", "ACACB", "ACAD9", "ACADM", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACBD5", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT8", "ACOT9", "ACOX1", "ACOX3", "ACP1", "ACP2", "ACP6", "ACSL1", "ACSL3", "ACSL4", "ACTN1", "ACTN2", "ACTN4", "ACTR10", "ACTR1A", "ACTR2", "ACTR3", "ADA", "ADAR", "ADD1", "ADD3", "ADH5", "ADI1", "ADK", "ADNP", "ADPGK", "ADPRHL2", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGK", "AGL", "AGPAT1", "AGPS", "AHCTF1", "AHCY", "AHCYL1", "AHNAK", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AK4", "AK6", "AKAP12", "AKAP13", "AKAP8", "AKAP8L", "AKR1A1", "AKR1B1", "AKR7A2", "AKT2", "ALDH18A1", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALG1", "ALKBH5", "AMOT", "ANAPC1", "ANAPC16", "ANAPC4", "ANAPC5", "ANAPC7", "ANK3", "ANKFY1", "ANKHD1", "ANKLE2", "ANKRD50", "ANLN", "ANP32A", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP1M1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "APC", "APEH", "APEX1", "API5", "APMAP", "APOL2", "APOOL", "APP", "APPL1", "APRT", "AQR", "ARCN1", "ARF4", "ARF5", "ARFGAP1", "ARFIP1", "ARFIP2", "ARHGAP17", "ARHGDIA", "ARHGEF1", "ARHGEF2", "ARID1A", "ARID3B", "ARIH1", "ARL1", "ARL2", "ARL3", "ARL6IP1", "ARL6IP5", "ARL8B", "ARMC1", "ARMC6", "ARMC8", "ARMCX3", "ARMT1", "ARPC1A", "ARPC2", "ARPC3", "ARPC4", "ARPC5", "ASAH1", "ASCC3", "ASF1A", "ASNA1", "ASNS", "ASPH", "ATAD1", "ATAD3A", "ATAD3B", "ATAD5", "ATE1", "ATG7", "ATIC", "ATL2", "ATP13A1", "ATP1A1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5L", "ATP5O", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1D", "ATP6V1E1", "ATP6V1H", "ATPAF1", "ATPIF1", "ATXN10", "ATXN2L", "AUP1", "AURKA", "B3GALT6", "B4GAT1", "BABAM1", "BAG2", "BAG4", "BAG5", "BAG6", "BAIAP2", "BAK1", "BANF1", "BAP18", "BASP1", "BAZ1A", "BAZ1B", "BCAP31", "BCAS2", "BCAS3", "BCCIP", "BCL2L13", "BCLAF1", "BCS1L", "BDH2", "BICD2", "BIRC6", "BLMH", "BLVRA", "BLVRB", "BMS1", "BNIP1", "BOP1", "BPNT1", "BPTF", "BRAT1", "BRD4", "BRI3BP", "BRIX1", "BSG", "BTAF1", "BTF3", "BUB1", "BUB1B", "BUB3", "BUD31", "BYSL", "BZW1", "BZW2", "C11orf58", "C12orf43", "C12orf73", "C19orf70", "C1QBP", "C1orf122", "C1orf35", "CACYBP", "CAD", "CALD1", "CALM3", "CALR", "CALU", "CAMK2G", "CAND1", "CANX", "CAP1", "CAPN1", "CAPNS1", "CAPRIN1", "CAPZA1", "CAPZB", "CARHSP1", "CARM1", "CARS", "CARS2", "CASK", "CASP3", "CASP6", "CASP7", "CASP8", "CAST", "CBR1", "CBX1", "CBX3", "CBX5", "CBX8", "CCAR1", "CCAR2", "CCDC124", "CCDC134", "CCDC137", "CCDC138", "CCDC22", "CCDC47", "CCDC6", "CCDC86", "CCDC93", "CCDC94", "CCNB1", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2AP", "CD2BP2", "CD3EAP", "CD47", "CDC123", "CDC16", "CDC23", "CDC27", "CDC37", "CDC40", "CDC42", "CDC45", "CDC5L", "CDC73", "CDCA5", "CDIPT", "CDK1", "CDK12", "CDK2", "CDK4", "CDK5RAP3", "CDK6", "CDKN2AIP", "CDS2", "CDV3", "CDX2", "CEBPZ", "CELF1", "CENPV", "CEP44", "CEP55", "CERS1", "CERS2", "CETN2", "CFAP20", "CFL1", "CFL2", "CGGBP1", "CHAC2", "CHAF1B", "CHAMP1", "CHCHD3", "CHD1", "CHD4", "CHEK2", "CHERP", "CHID1", "CHKA", "CHML", "CHMP1A", "CHMP2B", "CHMP5", "CHMP6", "CHMP7", "CHORDC1", "CHRAC1", "CHST14", "CIAPIN1", "CIP2A", "CIRBP", "CISD1", "CISD2", "CIZ1", "CKAP2", "CKAP4", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLCC1", "CLCN3", "CLGN", "CLIC1", "CLIC4", "CLINT1", "CLN5", "CLNS1A", "CLPB", "CLPP", "CLPTM1", "CLPTM1L", "CLPX", "CLTA", "CLTC", "CLUH", "CMPK1", "CMSS1", "CNDP2", "CNN2", "CNN3", "CNNM3", "CNNM4", "CNOT1", "CNOT7", "CNOT9", "CNP", "CNPY2", "COA3", "COA7", "COASY", "COG2", "COG6", "COIL", "COLEC12", "COLGALT1", "COMMD4", "COMT", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS7A", "COPS7B", "COPS8", "COPZ1", "COQ8A", "COQ9", "CORO1B", "CORO1C", "COTL1", "COX15", "COX2", "COX4I1", "COX5A", "COX5B", "COX6C", "COX7C", "CPD", "CPNE1", "CPNE3", "CPOX", "CPPED1", "CPSF1", "CPSF2", "CPSF3", "CPSF6", "CPSF7", "CPT1A", "CPT2", "CPVL", "CRKL", "CRMP1", "CRNKL1", "CRTAP", "CRYZ", "CS", "CSDE1", "CSE1L", "CSK", "CSNK1A1", "CSNK2A2", "CSNK2B", "CSTB", "CSTF1", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTDSPL2", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTPS2", "CTR9", "CTSA", "CTSC", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4A", "CUL4B", "CUL5", "CUTA", "CWF19L1", "CXorf57", "CYB5B", "CYB5D2", "CYB5R3", "CYC1", "CYFIP1", "CYP20A1", "CYP51A1", "DAD1", "DAGLB", "DAP3", "DARS", "DARS2", "DAZAP1", "DBN1", "DBNL", "DCAF1", "DCAF13", "DCAF7", "DCAKD", "DCD", "DCP1A", "DCPS", "DCTD", "DCTN1", "DCTN2", "DCTN3", "DCTN4", "DCTN6", "DCTPP1", "DCUN1D4", "DCUN1D5", "DCXR", "DDAH1", "DDB1", "DDI2", "DDOST", "DDRGK1", "DDT", "DDX1", "DDX10", "DDX17", "DDX18", "DDX20", "DDX21", "DDX23", "DDX24", "DDX28", "DDX39A", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX50", "DDX51", "DDX52", "DDX54", "DDX55", "DDX56", "DDX6", "DEK", "DENR", "DERL1", "DFFA", "DHCR24", "DHCR7", "DHFR", "DHPS", "DHRS7B", "DHX15", "DHX16", "DHX30", "DHX36", "DHX37", "DHX38", "DHX8", "DHX9", "DIABLO", "DIAPH1", "DIAPH3", "DICER1", "DIDO1", "DIEXF", "DIP2B", "DIS3", "DKC1", "DLAT", "DLD", "DLST", "DNAAF5", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC2", "DNAJC3", "DNAJC7", "DNAJC8", "DNAJC9", "DNM1L", "DNM2", "DNMT1", "DNPH1", "DNTTIP2", "DOCK7", "DOHH", "DOLPP1", "DPF2", "DPH2", "DPH5", "DPP3", "DPP9", "DPYSL2", "DPYSL3", "DRG1", "DRG2", "DSG2", "DSP", "DST", "DSTN", "DTL", "DTYMK", "DUSP3", "DUSP9", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNLL1", "DYNLL2", "EARS2", "EBNA1BP2", "EBP", "ECD", "ECE1", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "ECSIT", "EDC3", "EDC4", "EDF1", "EEA1", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EEFSEC", "EFL1", "EFTUD2", "EHD1", "EHD4", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2D", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAC2", "ELAVL1", "ELOB", "ELOC", "ELP1", "ELP2", "ELP3", "EMC1", "EMC2", "EMC3", "EMC4", "EMD", "EMG1", "EML4", "ENAH", "ENDOD1", "ENO1", "ENSA", "EPB41", "EPB41L2", "EPB41L3", "EPHX1", "EPHX2", "EPPK1", "EPRS", "EPS15", "EPS15L1", "ERAL1", "ERAP1", "ERCC2", "ERCC3", "ERGIC2", "ERGIC3", "ERH", "ERLIN1", "ERLIN2", "ERMP1", "ERO1A", "ERP29", "ERP44", "ESD", "ESF1", "ESYT1", "ESYT2", "ETF1", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXO1", "EXOC1", "EXOC2", "EXOC4", "EXOC5", "EXOC7", "EXOSC10", "EXOSC3", "EXOSC4", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC8", "EZR", "F11R", "FABP5", "FADS2", "FAF1", "FAF2", "FAH", "FAHD1", "FAM114A2", "FAM120A", "FAM162A", "FAM208A", "FAM213A", "FAM3C", "FAM49B", "FAM50A", "FAM8A1", "FAM91A1", "FAM98A", "FAM98B", "FANCI", "FAR1", "FARSA", "FARSB", "FASN", "FASTKD2", "FBL", "FBXO22", "FBXO7", "FDFT1", "FDPS", "FDX1", "FDXR", "FECH", "FEN1", "FERMT2", "FGFR1OP", "FH", "FHL1", "FHOD1", "FIP1L1", "FIS1", "FKBP10", "FKBP14", "FKBP1A", "FKBP3", "FKBP4", "FKBP5", "FKBP7", "FKBP8", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FMR1", "FN3KRP", "FNDC3A", "FNTB", "FOXC1", "FOXRED1", "FRYL", "FSCN1", "FTO", "FTSJ1", "FTSJ3", "FUBP1", "FUBP3", "FUCA1", "FUCA2", "FUNDC2", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GADD45GIP1", "GALK1", "GALNT2", "GALNT7", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GATAD2B", "GATB", "GATC", "GBA", "GBE1", "GBF1", "GCAT", "GCC2", "GCDH", "GCLM", "GCN1", "GDAP1", "GDI1", "GDI2", "GDPD1", "GEMIN4", "GEMIN5", "GET4", "GFM1", "GFPT1", "GGA1", "GGCT", "GGCX", "GGH", "GHDC", "GHITM", "GIGYF2", "GINS2", "GINS3", "GINS4", "GLA", "GLB1", "GLDC", "GLG1", "GLMN", "GLO1", "GLOD4", "GLRX3", "GLRX5", "GLS", "GLUD1", "GLYR1", "GM2A", "GMDS", "GMFB", "GMPPA", "GMPPB", "GMPS", "GNA13", "GNAI1", "GNAI2", "GNAI3", "GNL1", "GNL2", "GNL3", "GNL3L", "GNPDA1", "GNS", "GOLGA3", "GOLGB1", "GOLIM4", "GOLPH3", "GOLT1B", "GORASP2", "GOT1", "GOT2", "GPAM", "GPATCH8", "GPD2", "GPHN", "GPI", "GPKOW", "GPR107", "GPR108", "GPR89B", "GPS1", "GPT2", "GPX8", "GRB2", "GRHPR", "GRPEL1", "GRSF1", "GRWD1", "GSK3A", "GSK3B", "GSPT1", "GSR", "GSS", "GSTK1", "GSTM3", "GSTO1", "GSTZ1", "GTF2B", "GTF2E1", "GTF2F1", "GTF2F2", "GTF2I", "GTF3C1", "GTF3C2", "GTF3C3", "GTPBP1", "GTPBP10", "GTPBP3", "GTPBP4", "GUSB", "GYG1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACD3", "HADH", "HADHA", "HADHB", "HAT1", "HAUS4", "HAUS5", "HBS1L", "HCCS", "HCFC1", "HDAC2", "HDGF", "HDGFL2", "HDHD2", "HDHD3", "HDHD5", "HDLBP", "HEATR1", "HEATR3", "HEATR6", "HEBP1", "HECTD1", "HELLS", "HEXA", "HEXB", "HGH1", "HGS", "HIBADH", "HIBCH", "HINT2", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HLTF", "HM13", "HMBS", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMGCL", "HMGCS1", "HMOX1", "HMOX2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HNRNPUL2", "HOOK3", "HP1BP3", "HPRT1", "HS2ST1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSDL1", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA14", "HSPA1B", "HSPA2", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPB1", "HSPBP1", "HSPD1", "HSPE1", "HSPH1", "HTATSF1", "HTT", "HUS1", "HUWE1", "HYOU1", "IARS", "IARS2", "IBA57", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDI1", "IFIT5", "IFT27", "IGBP1", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IK", "IKBIP", "ILF2", "ILF3", "ILK", "ILKAP", "ILVBL", "IMMT", "IMP3", "IMPDH1", "IMPDH2", "INA", "INF2", "INTS13", "INTS14", "INTS3", "INTS7", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IRGQ", "IRS4", "ISOC1", "IST1", "ISYNA1", "ITCH", "ITGB1", "ITPA", "IVD", "IWS1", "JPT2", "JUP", "KARS", "KAT7", "KCTD12", "KCTD5", "KDELC2", "KDELR1", "KDM1A", "KDM1B", "KDM2A", "KDM3B", "KDSR", "KHDRBS1", "KHDRBS3", "KHSRP", "KIAA0319L", "KIAA0368", "KIAA1468", "KIAA2013", "KIF11", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF3A", "KIF4A", "KIF5B", "KIFBP", "KIFC1", "KLC1", "KLC2", "KLC4", "KNOP1", "KPNA1", "KPNA2", "KPNA3", "KPNA6", "KPNB1", "KRI1", "KTN1", "KYAT3", "L2HGDH", "LAMP1", "LAMP2", "LAMTOR1", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LAS1L", "LASP1", "LBR", "LDHA", "LDHB", "LDLR", "LEMD2", "LEMD3", "LENG8", "LETM1", "LGALS3", "LGALS3BP", "LGMN", "LIG1", "LIG3", "LIMA1", "LIPA", "LLGL1", "LMAN1", "LMAN2", "LMNA", "LMNB1", "LMNB2", "LNPEP", "LNPK", "LONP1", "LPCAT1", "LPP", "LRBA", "LRPAP1", "LRPPRC", "LRRC40", "LRRC47", "LRRC57", "LRRC59", "LSM12", "LSM6", "LSM7", "LSM8", "LSS", "LTA4H", "LTV1", "LUC7L2", "LYAR", "LYPLA1", "LYRM2", "LZIC", "LZTFL1", "M6PR", "MACF1", "MAD1L1", "MAD2L1", "MAGED2", "MAGT1", "MAIP1", "MAK16", "MAP1B", "MAP1S", "MAP2K1", "MAP2K2", "MAP2K3", "MAP4", "MAPK1", "MAPK14", "MAPRE1", "MAPRE2", "MARC1", "MARCKS", "MARS", "MARS2", "MASTL", "MAT2A", "MAT2B", "MATR3", "MAU2", "MAVS", "MBNL1", "MBOAT7", "MCAT", "MCCC1", "MCCC2", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCMBP", "MCTS1", "MCU", "MCUR1", "MDC1", "MDH1", "MDH2", "MDN1", "ME2", "MEAF6", "MECP2", "MED1", "MED24", "MESD", "METAP1", "METTL13", "MFAP1", "MFN1", "MFN2", "MFSD5", "MGEA5", "MGME1", "MGST2", "MGST3", "MIA2", "MIA3", "MICU1", "MICU2", "MID1", "MIF", "MIGA1", "MINPP1", "MIOS", "MIPEP", "MKI67", "MLEC", "MMAB", "MMS19", "MOGS", "MON2", "MORF4L1", "MOSPD2", "MOV10", "MPDU1", "MPHOSPH10", "MPI", "MPP1", "MPP2", "MPP6", "MPRIP", "MPST", "MPV17L2", "MRC2", "MRE11", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL14", "MRPL15", "MRPL17", "MRPL19", "MRPL20", "MRPL21", "MRPL37", "MRPL38", "MRPL39", "MRPL40", "MRPL43", "MRPL44", "MRPL47", "MRPL48", "MRPL49", "MRPL50", "MRPL53", "MRPL58", "MRPL9", "MRPS15", "MRPS17", "MRPS2", "MRPS22", "MRPS23", "MRPS25", "MRPS27", "MRPS30", "MRPS31", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRPS9", "MRTO4", "MSH2", "MSH3", "MSH6", "MSI1", "MSMO1", "MSN", "MSTO1", "MTA1", "MTA2", "MTAP", "MTBP", "MTCH1", "MTCH2", "MTDH", "MTFP1", "MTHFD1L", "MTHFD2", "MTOR", "MTPAP", "MTPN", "MTR", "MTX1", "MTX2", "MUT", "MXRA7", "MYBBP1A", "MYCBP", "MYDGF", "MYG1", "MYH10", "MYH14", "MYH9", "MYL6", "MYO1B", "MYO1D", "MYO6", "NAA10", "NAA15", "NAA25", "NAA35", "NAA40", "NAA50", "NADK2", "NAE1", "NAF1", "NAGK", "NAGLU", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NAPG", "NARS", "NASP", "NAT10", "NAXE", "NBN", "NCAPD2", "NCAPG", "NCAPH", "NCBP1", "NCBP2", "NCDN", "NCKAP1", "NCL", "NCLN", "NCOA5", "NCSTN", "NDC1", "NDRG3", "NDUFA10", "NDUFA11", "NDUFA13", "NDUFA2", "NDUFA4", "NDUFA5", "NDUFA7", "NDUFA8", "NDUFA9", "NDUFAF4", "NDUFAF7", "NDUFB10", "NDUFB11", "NDUFB3", "NDUFB4", "NDUFB5", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS7", "NDUFS8", "NDUFV1", "NDUFV2", "NECAP2", "NEFL", "NEFM", "NEK9", "NELFA", "NELFCD", "NELFE", "NEMF", "NENF", "NES", "NFKB1", "NFS1", "NHLRC2", "NHP2", "NIFK", "NIP7", "NIPSNAP2", "NISCH", "NKRF", "NKTR", "NLE1", "NLN", "NMD3", "NME1", "NME2", "NMT1", "NNT", "NOC2L", "NOC3L", "NOC4L", "NOL10", "NOL11", "NOL6", "NOL7", "NOL8", "NOL9", "NOLC1", "NONO", "NOP10", "NOP14", "NOP16", "NOP2", "NOP56", "NOP58", "NOP9", "NOSIP", "NPC1", "NPEPPS", "NPLOC4", "NPM1", "NRBP1", "NRDC", "NSA2", "NSD2", "NSDHL", "NSF", "NSFL1C", "NSUN2", "NSUN5", "NT5C2", "NT5C3B", "NT5DC1", "NT5DC2", "NTMT1", "NTPCR", "NUB1", "NUBP2", "NUBPL", "NUCB1", "NUCB2", "NUCKS1", "NUDC", "NUDCD1", "NUDCD2", "NUDT1", "NUDT21", "NUDT5", "NUDT9", "NUFIP2", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP160", "NUP188", "NUP205", "NUP210", "NUP214", "NUP35", "NUP37", "NUP50", "NUP54", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NUTF2", "NVL", "NXF1", "NXN", "OAT", "OCIAD1", "OCLN", "OGDH", "OGT", "OLA1", "OPA1", "OPA3", "OSBP", "OSBPL11", "OSBPL6", "OSBPL8", "OSBPL9", "OSGEP", "OTUB1", "OXA1L", "P3H1", "P3H4", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PACSIN3", "PAF1", "PAFAH1B1", "PAFAH1B3", "PAICS", "PAK1", "PAK1IP1", "PAK2", "PALLD", "PANK4", "PAPSS1", "PARK7", "PARN", "PARP1", "PARP2", "PASK", "PBDC1", "PBK", "PBRM1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCID2", "PCK2", "PCLAF", "PCM1", "PCMT1", "PCNA", "PCNP", "PCYOX1", "PDAP1", "PDCD11", "PDCD4", "PDCD5", "PDCD6", "PDCD6IP", "PDCL3", "PDE12", "PDE4DIP", "PDE6D", "PDHA1", "PDHB", "PDIA3", "PDIA4", "PDIA6", "PDK3", "PDLIM1", "PDLIM5", "PDLIM7", "PDS5A", "PDS5B", "PDXK", "PEBP1", "PECR", "PEF1", "PELO", "PELP1", "PEPD", "PES1", "PEX11G", "PEX14", "PEX19", "PEX5", "PFAS", "PFDN2", "PFDN4", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGP", "PGRMC1", "PGRMC2", "PHB", "PHB2", "PHF5A", "PHF6", "PHF8", "PHGDH", "PI4K2A", "PI4KB", "PICALM", "PIGK", "PIGS", "PIH1D1", "PIK3C3", "PIN1", "PIN4", "PINX1", "PIP4K2C", "PIR", "PISD", "PITHD1", "PITPNA", "PITPNB", "PITRM1", "PKM", "PKMYT1", "PKN1", "PKN2", "PLA2G15", "PLAA", "PLBD2", "PLCG1", "PLD3", "PLD6", "PLEC", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLRG1", "PLS3", "PM20D2", "PMPCA", "PMPCB", "PNN", "PNO1", "PNP", "PNPLA8", "PNPT1", "POFUT1", "POGZ", "POLA1", "POLA2", "POLD1", "POLDIP2", "POLDIP3", "POLE", "POLE3", "POLE4", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2B", "POLR2C", "POLR2E", "POLR2G", "POLR2L", "POLR3A", "POLRMT", "PON2", "POP1", "POR", "PPA1", "PPA2", "PPAN", "PPAT", "PPFIA1", "PPIB", "PPID", "PPIE", "PPIF", "PPIH", "PPIL1", "PPIL4", "PPM1G", "PPME1", "PPOX", "PPP1CA", "PPP1CB", "PPP1R10", "PPP1R12A", "PPP1R7", "PPP1R8", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP4R3A", "PPP5C", "PPP6C", "PPT1", "PPT2", "PQBP1", "PRAF2", "PRC1", "PRCC", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PREP", "PREPL", "PRIM1", "PRIM2", "PRKACA", "PRKAG1", "PRKAR1A", "PRKAR2A", "PRKCSH", "PRKDC", "PRKRA", "PRMT1", "PRMT3", "PRMT5", "PRMT9", "PRPF19", "PRPF3", "PRPF31", "PRPF38B", "PRPF39", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPS2", "PRPSAP1", "PRPSAP2", "PRRC1", "PRRC2A", "PRRC2C", "PSAP", "PSAT1", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD6", "PSMD7", "PSMD8", "PSME1", "PSME2", "PSME3", "PSME4", "PSMF1", "PSMG1", "PSMG3", "PSPC1", "PTBP1", "PTBP2", "PTCD1", "PTCD3", "PTDSS1", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK7", "PTPA", "PTPN1", "PTRH2", "PTRHD1", "PUF60", "PUM1", "PUM3", "PURA", "PUS7", "PWP1", "PWP2", "PXMP2", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QDPR", "QKI", "QRSL1", "RAB10", "RAB11B", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB1B", "RAB24", "RAB3GAP1", "RAB3GAP2", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RAB8A", "RAB8B", "RAB9A", "RABEP1", "RABEPK", "RABGAP1", "RAC1", "RACK1", "RAD21", "RAD23A", "RAD23B", "RAD50", "RAD9A", "RAE1", "RAI14", "RALA", "RALB", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP9", "RANGAP1", "RAP1GDS1", "RAPGEF2", "RARS", "RARS2", "RAVER1", "RBBP5", "RBBP6", "RBM10", "RBM12", "RBM12B", "RBM14", "RBM17", "RBM19", "RBM22", "RBM25", "RBM26", "RBM27", "RBM28", "RBM3", "RBM34", "RBM39", "RBM4", "RBM42", "RBM4B", "RBM5", "RBM8A", "RBMX", "RBMXL1", "RBPMS", "RCC1", "RCC2", "RCL1", "RCN1", "RCN2", "RDH11", "RDH13", "RDH14", "RDX", "RECQL", "REEP5", "REPS1", "RER1", "RETSAT", "REXO2", "REXO4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RFX1", "RHEB", "RHOA", "RHOG", "RHOT1", "RIC8A", "RIDA", "RIF1", "RINT1", "RIOX2", "RIPK1", "RMDN1", "RNASEH2A", "RNASET2", "RNF14", "RNF20", "RNF219", "RNF40", "RNH1", "RNPEP", "RNPS1", "ROCK2", "RP2", "RPA1", "RPA2", "RPAP1", "RPAP3", "RPF2", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPN1", "RPN2", "RPP30", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RRBP1", "RRM1", "RRM2", "RRP1", "RRP12", "RRP15", "RRP1B", "RRP8", "RRS1", "RSF1", "RSL1D1", "RSU1", "RTCB", "RTN2", "RTN3", "RTN4", "RTN4IP1", "RTRAF", "RUFY1", "RUVBL1", "RUVBL2", "S100A10", "S100A11", "S100A13", "SACM1L", "SAE1", "SAFB", "SAFB2", "SAMHD1", "SAMM50", "SAP130", "SAP18", "SAR1A", "SARNP", "SARS", "SARS2", "SART1", "SART3", "SBDS", "SC5D", "SCAF1", "SCAF4", "SCAMP1", "SCAMP2", "SCAMP3", "SCARB1", "SCARB2", "SCCPDH", "SCD", "SCFD1", "SCML2", "SCO1", "SCO2", "SCP2", "SCPEP1", "SCRIB", "SCRN1", "SDF4", "SDHA", "SDHB", "SEC11A", "SEC16A", "SEC22B", "SEC23A", "SEC23B", "SEC23IP", "SEC24A", "SEC24B", "SEC24C", "SEC31A", "SEC61A1", "SEC61B", "SEC62", "SEC63", "SEH1L", "SEL1L", "SENP3", "SEPHS1", "SEPT11", "SEPT2", "SEPT7", "SEPT9", "SERBP1", "SERPINB6", "SERPINH1", "SET", "SETD2", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFSWAP", "SFXN1", "SFXN4", "SGPL1", "SGTA", "SH3BGRL3", "SH3GL1", "SH3GLB1", "SH3GLB2", "SHCBP1", "SHMT1", "SHMT2", "SHOC2", "SHTN1", "SIGMAR1", "SIRT1", "SKIV2L", "SKIV2L2", "SKP1", "SKP2", "SLAIN1", "SLC16A1", "SLC19A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A17", "SLC25A20", "SLC25A22", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A33", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A4", "SLC29A1", "SLC2A1", "SLC33A1", "SLC35B2", "SLC35F2", "SLC3A2", "SLC7A1", "SLC9A3R1", "SLFN11", "SLIRP", "SLIT2", "SLK", "SLTM", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCC1", "SMARCC2", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC6", "SMCHD1", "SMN1*", "SMNDC1", "SMPD4", "SMU1", "SMYD3", "SMYD4", "SNAP23", "SNAP29", "SND1", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPC", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNU13", "SNW1", "SNX1", "SNX12", "SNX17", "SNX2", "SNX27", "SNX3", "SNX5", "SNX6", "SNX9", "SOAT1", "SOD2", "SON", "SORD", "SORT1", "SPAG9", "SPART", "SPATA5L1", "SPC24", "SPC25", "SPCS2", "SPECC1L", "SPEN", "SPOUT1", "SPPL2A", "SPR", "SPTAN1", "SPTBN1", "SPTBN2", "SPTLC1", "SPTLC2", "SQLE", "SQSTM1", "SREK1", "SRI", "SRM", "SRP14", "SRP54", "SRP68", "SRP72", "SRP9", "SRPK1", "SRPRA", "SRPRB", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF3", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSNA1", "SSR1", "SSR4", "SSRP1", "STAG1", "STAG2", "STAM", "STAMBP", "STARD3", "STARD3NL", "STARD7", "STAT1", "STAT3", "STAU1", "STAU2", "STIP1", "STK4", "STMN1", "STOM", "STOML2", "STRAP", "STRBP", "STRN", "STT3A", "STUB1", "STX12", "STX18", "STX5", "STX7", "STXBP3", "STXBP4", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGP2", "SUGT1", "SUN1", "SUPT16H", "SUPT5H", "SUPT6H", "SUPV3L1", "SURF4", "SURF6", "SUZ12", "SV2A", "SYAP1", "SYMPK", "SYNCRIP", "SYNE2", "SYNGR2", "SYNJ2BP", "TACC3", "TAF15", "TAGLN2", "TALDO1", "TAMM41", "TARDBP", "TARS", "TARS2", "TBC1D10B", "TBC1D13", "TBC1D15", "TBC1D4", "TBC1D9B", "TBCA", "TBCC", "TBCD", "TBCE", "TBL3", "TBRG4", "TCAF1", "TCEA1", "TCERG1", "TCOF1", "TCP1", "TDP2", "TDRKH", "TECR", "TELO2", "TERF2IP", "TEX10", "TEX264", "TFAM", "TFCP2", "TFG", "TFRC", "THOC1", "THOC2", "THOC3", "THOC6", "THOP1", "THRAP3", "THUMPD1", "THUMPD3", "TIA1", "TIAL1", "TIGAR", "TIMM10", "TIMM17A", "TIMM17B", "TIMM23", "TIMM44", "TIMM50", "TIMM8B", "TIPRL", "TJP1", "TK1", "TKFC", "TKT", "TLN1", "TM9SF3", "TMA16", "TMCO1", "TMED10", 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"TXLNG", "TXNDC12", "TXNDC17", "TXNDC5", "TXNL1", "TXNRD1", "TYMS", "U2AF1", "U2AF2", "U2SURP", "UAP1", "UBA1", "UBA2", "UBA3", "UBA6", "UBAP2", "UBAP2L", "UBE2G2", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2O", "UBE2S", "UBE3A", "UBE4B", "UBFD1", "UBLCP1", "UBQLN4", "UBR4", "UBR5", "UBTF", "UBXN1", "UCHL5", "UFC1", "UFD1", "UFL1", "UFM1", "UGDH", "UGGT1", "UGP2", "UHRF1", "UMPS", "UNC119", "UNC119B", "UNC45A", "UNG", "UPF1", "UQCC1", "UQCR10", "UQCRB", "UQCRC1", "UQCRC2", "UQCRQ", "URB1", "UROD", "USMG5", "USO1", "USP10", "USP11", "USP14", "USP15", "USP39", "USP47", "USP48", "USP5", "USP7", "USP9X", "UTP11", "UTP14A", "UTP15", "UTP18", "UTP20", "UTP3", "UTP4", "UTP6", "UTRN", "VAMP7", "VANGL1", "VAPA", "VAPB", "VARS1", "VARS2", "VAT1", "VBP1", "VCL", "VCP", "VDAC1", "VDAC2", "VDAC3", "VIM", "VIPAS39", "VIRMA", "VKORC1L1", "VMP1", "VPS18", "VPS26A", "VPS29", "VPS33A", "VPS33B", "VPS35", "VPS4B", "VPS52", "VRK1", "VTA1", "VTI1B", "WAPL", "WARS", "WASHC4", "WBP11", "WBP2", "WDHD1", 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0000000000000000000000000000000000000000..ff4434919e6a4af647c39daac04ecb1bbdd4704b --- /dev/null +++ b/protein_atlas_subcellular_location_all/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/protein_atlas_subcellular_location_all/fragment/C166/C166_val_log2fc"} \ No newline at end of file diff --git a/protein_atlas_subcellular_location_all/result.tsv b/protein_atlas_subcellular_location_all/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..39fa18f5cdc0cbd4d719c2d5cf78f2f509d0159c --- /dev/null +++ b/protein_atlas_subcellular_location_all/result.tsv @@ -0,0 +1,9 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Endoplasmic reticulum 0.4981951400514185 4.4889123612238855 7.158773898119364e-06 0.0002290553475297 0.0002290807647398 187 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"CDKN2AIP", "CDS2", "CDV3", "CDX2", "CEBPZ", "CELF1", "CENPV", "CEP55", "CERS1", "CERS2", "CETN2", "CFAP20", "CFL1", "CFL2", "CGGBP1", "CHAC2", "CHAF1B", "CHAMP1", "CHCHD3", "CHD1", "CHD4", "CHEK2", "CHID1", "CHKA", "CHML", "CHMP1A", "CHMP2B", "CHMP5", "CHMP7", "CHORDC1", "CHRAC1", "CHST14", "CIAPIN1", "CIP2A", "CIRBP", "CISD1", "CISD2", "CIZ1", "CKAP2", "CKAP5", "CKB", "CLCC1", "CLCN3", "CLGN", "CLIC1", "CLIC4", "CLINT1", "CLNS1A", "CLPP", "CLPTM1", "CLPTM1L", "CLPX", "CLTA", "CLTC", "CLUH", "CMPK1", "CMSS1", "CNDP2", "CNN2", "CNN3", "CNNM3", "CNNM4", "CNOT1", "CNOT7", "CNOT9", "CNP", "CNPY2", "COA3", "COA7", "COG2", "COG6", "COIL", "COLEC12", "COLGALT1", "COMMD4", "COMT", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPS2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS7A", "COPS7B", "COPS8", "COQ8A", "COQ9", "CORO1B", "COTL1", "COX15", "COX4I1", "COX5B", "COX6C", "CPD", "CPNE1", "CPNE3", "CPOX", "CPPED1", "CPSF1", "CPSF2", "CPSF6", "CPSF7", "CPT1A", "CPT2", "CPVL", "CRKL", "CRMP1", "CRTAP", "CRYZ", "CS", "CSDE1", "CSE1L", "CSK", "CSNK1A1", "CSTB", "CSTF1", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTDSPL2", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTPS2", "CTR9", "CTSA", "CTSC", "CTTN", "CUL1", "CUL2", "CUL4A", "CUL4B", "CUL5", "CUTA", "CWF19L1", "CXorf57", "CYB5B", "CYB5D2", "CYB5R3", "CYC1", "CYP20A1", "CYP51A1", "DAD1", "DAGLB", "DAP3", "DARS", "DARS2", "DAZAP1", "DBN1", "DBNL", "DCAF1", "DCAF13", "DCAF7", "DCAKD", "DCP1A", "DCPS", "DCTD", "DCTN1", "DCTN2", "DCTN3", "DCTN4", "DCTN6", "DCTPP1", "DCUN1D4", "DCUN1D5", "DCXR", "DDAH1", "DDB1", "DDI2", "DDOST", "DDRGK1", "DDT", "DDX1", "DDX10", "DDX17", "DDX18", "DDX20", "DDX21", "DDX23", "DDX24", "DDX28", "DDX39A", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX50", "DDX51", "DDX52", "DDX54", "DDX55", "DDX56", "DDX6", "DEK", "DENR", "DERL1", "DFFA", "DHCR7", "DHFR", "DHPS", "DHRS7B", "DHX15", "DHX16", "DHX30", "DHX36", "DHX37", "DHX38", "DHX8", "DHX9", "DIABLO", "DIAPH1", "DIAPH3", "DICER1", "DIDO1", "DIP2B", "DIS3", "DKC1", "DLAT", "DLD", "DLST", "DNAAF5", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJC1", "DNAJC11", "DNAJC2", "DNAJC3", "DNAJC7", "DNAJC8", "DNAJC9", "DNM1L", "DNM2", "DNMT1", "DNPH1", "DNTTIP2", "DOHH", "DOLPP1", "DPF2", "DPH2", "DPH5", "DPP3", "DPP9", "DPYSL2", "DPYSL3", "DRG1", "DRG2", "DSG2", "DSP", "DST", "DTL", "DTYMK", "DUSP3", "DUSP9", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNLL1", "DYNLL2", "EARS2", "EBNA1BP2", "EBP", "ECD", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "ECSIT", "EDC3", "EDC4", "EDF1", "EEA1", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EEFSEC", "EFL1", "EFTUD2", "EHD1", "EHD4", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2D", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAC2", "ELAVL1", "ELOC", "ELP1", "ELP2", "ELP3", "EMD", "EMG1", "EML4", "ENAH", "ENDOD1", "ENO1", "ENSA", "EPB41", "EPB41L2", "EPB41L3", "EPHX2", "EPPK1", "EPRS", "EPS15", "EPS15L1", "ERAL1", "ERAP1", "ERCC2", "ERCC3", "ERGIC2", "ERH", "ERLIN1", "ERLIN2", "ERP29", "ESD", "ESF1", "ESYT1", "ESYT2", "ETFA", "ETFB", "EWSR1", "EXO1", "EXOC1", "EXOC2", "EXOC4", "EXOC7", "EXOSC10", "EXOSC3", "EXOSC4", "EXOSC5", "EXOSC7", "EXOSC8", "EZR", "F11R", "FABP5", "FAF1", "FAF2", "FAH", "FAHD1", "FAM114A2", "FAM120A", "FAM162A", "FAM208A", "FAM3C", "FAM49B", "FAM50A", "FAM8A1", "FAM91A1", "FAM98A", "FAM98B", "FANCI", "FAR1", "FARSA", "FARSB", "FASN", "FASTKD2", "FBL", "FBXO7", "FDFT1", "FDPS", "FDX1", "FDXR", "FEN1", "FERMT2", "FGFR1OP", "FH", "FHL1", "FHOD1", "FIP1L1", "FIS1", "FKBP10", "FKBP14", "FKBP3", "FKBP4", "FKBP5", "FKBP7", "FKBP8", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FMR1", "FN3KRP", "FNDC3A", "FNTB", "FOXC1", "FOXRED1", "FRYL", "FSCN1", "FTO", "FTSJ1", "FTSJ3", "FUBP1", "FUBP3", "FUCA1", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GADD45GIP1", "GALK1", "GALNT2", "GALNT7", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GATAD2B", "GATB", "GBE1", "GBF1", "GCAT", "GCC2", "GCDH", "GCLM", "GCN1", "GDAP1", "GDI1", "GDI2", "GEMIN4", "GEMIN5", "GET4", "GFM1", "GFPT1", "GGA1", "GHITM", "GIGYF2", "GINS2", "GINS3", "GINS4", "GLB1", "GLDC", "GLG1", "GLMN", "GLO1", "GLOD4", "GLRX5", "GLS", "GLUD1", "GLYR1", "GM2A", "GMFB", "GMPPA", "GMPS", "GNA13", "GNAI1", "GNAI2", "GNAI3", "GNL1", "GNL2", "GNL3", "GNL3L", "GNPDA1", "GOLGA3", "GOLGB1", "GOLIM4", "GOLPH3", "GOLT1B", "GORASP2", "GOT1", "GPAM", "GPATCH8", "GPD2", "GPHN", "GPI", "GPKOW", "GPR107", "GPR108", "GPR89B", "GPS1", "GPT2", "GPX8", "GRB2", "GRHPR", "GRPEL1", "GRSF1", "GRWD1", "GSK3A", "GSK3B", "GSPT1", "GSR", "GSS", "GSTK1", "GSTM3", "GSTZ1", "GTF2B", "GTF2E1", "GTF2F1", "GTF2F2", "GTF2I", "GTF3C1", "GTF3C2", "GTF3C3", "GTPBP1", "GTPBP3", "GTPBP4", "GUSB", "GYG1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACD3", "HADH", "HADHA", "HADHB", "HAT1", "HBS1L", "HCCS", "HCFC1", "HDAC2", "HDGF", "HDGFL2", "HDHD2", "HDHD3", "HDHD5", "HDLBP", "HEATR1", "HEATR3", "HEATR6", "HEBP1", "HECTD1", "HELLS", "HEXA", "HGH1", "HGS", "HIBCH", "HINT2", "HIST1H1C", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLCS", "HLTF", "HM13", "HMBS", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMGCS1", "HMOX1", "HMOX2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HNRNPUL2", "HOOK3", "HP1BP3", "HPRT1", "HS2ST1", "HSD17B11", "HSD17B4", "HSDL1", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA1B", "HSPA2", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPB1", "HSPBP1", "HSPD1", "HSPH1", "HTATSF1", "HTT", "HUWE1", "IARS", "IARS2", "IBA57", "IDH1", "IDH2", "IDH3A", "IDH3B", "IFIT5", "IGBP1", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IK", "IKBIP", "ILF2", "ILF3", "ILK", "ILKAP", "ILVBL", "IMMT", "IMP3", "IMPDH1", "IMPDH2", "INA", "INF2", "INTS13", "INTS14", "INTS3", "INTS7", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IRGQ", "ISOC1", "IST1", "ISYNA1", "ITCH", "ITGB1", "ITPA", "IVD", "IWS1", "JPT2", "JUP", "KARS", "KAT7", "KCTD12", "KDELC2", "KDELR1", "KDM1A", "KDM1B", "KDM2A", "KDM3B", "KHDRBS1", "KHDRBS3", "KHSRP", "KIAA0319L", "KIAA0368", "KIAA1468", "KIAA2013", "KIF11", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF3A", "KIF4A", "KIF5B", "KIFC1", "KLC1", "KLC2", "KLC4", "KNOP1", "KPNA1", "KPNA2", "KPNA3", "KPNA6", "KPNB1", "KRI1", "KTN1", "KYAT3", "L2HGDH", "LAMP2", "LAMTOR1", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LAS1L", "LASP1", "LBR", "LDHA", "LDHB", "LEMD2", "LEMD3", "LENG8", "LETM1", "LGALS3", "LGMN", "LIG1", "LIG3", "LIMA1", "LIPA", "LMAN1", "LMNA", "LMNB1", "LMNB2", "LNPK", "LONP1", "LPCAT1", "LPP", "LRBA", "LRPAP1", "LRPPRC", "LRRC40", "LRRC47", "LRRC57", "LRRC59", "LSM12", "LSM6", "LSM7", "LSM8", "LTA4H", "LTV1", "LUC7L2", "LYAR", "LYPLA1", "LYRM2", "LZIC", "LZTFL1", "MACF1", "MAD1L1", "MAD2L1", "MAGED2", "MAIP1", "MAK16", "MAP1B", "MAP1S", "MAP2K1", "MAP2K2", "MAP2K3", "MAP4", "MAPK1", "MAPK14", "MAPRE1", "MAPRE2", "MARC1", "MARCKS", "MARS", "MASTL", "MAT2A", "MAT2B", "MATR3", "MAU2", "MAVS", "MBNL1", "MBOAT7", "MCAT", "MCCC1", "MCCC2", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCMBP", "MCTS1", "MCU", "MDC1", "MDH1", "MDH2", "MDN1", "ME2", "MEAF6", "MECP2", "MED1", "MESD", "METAP1", "METTL13", "MFAP1", "MFN1", "MFN2", "MGEA5", "MGME1", "MGST2", "MGST3", "MIA2", "MIA3", "MICU1", "MICU2", "MID1", "MIF", "MIGA1", "MIOS", "MIPEP", "MKI67", "MMAB", "MMS19", "MOGS", "MON2", "MORF4L1", "MOSPD2", "MOV10", "MPDU1", "MPHOSPH10", "MPI", "MPP1", "MPP2", "MPRIP", "MPST", "MRE11", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL14", "MRPL15", "MRPL19", "MRPL20", "MRPL21", "MRPL37", "MRPL38", "MRPL39", "MRPL40", "MRPL43", "MRPL44", "MRPL47", "MRPL48", "MRPL50", "MRPL53", "MRPL58", "MRPL9", "MRPS15", "MRPS2", "MRPS22", "MRPS23", "MRPS25", "MRPS27", "MRPS31", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRPS9", "MRTO4", "MSH2", "MSH3", "MSH6", "MSI1", "MSMO1", "MSN", "MSTO1", "MTA1", "MTA2", "MTAP", "MTBP", "MTCH2", "MTDH", "MTFP1", "MTHFD1L", "MTHFD2", "MTOR", "MTPAP", "MTPN", "MTR", "MTX1", "MTX2", "MUT", "MXRA7", "MYBBP1A", "MYCBP", "MYG1", "MYH10", "MYH14", "MYH9", "MYO1B", "MYO1D", "MYO6", "NAA10", "NAA15", "NAA25", "NAA35", "NAA40", "NAA50", "NADK2", "NAE1", "NAF1", "NAGK", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NAPG", "NARS", "NASP", "NAT10", "NAXE", "NBN", "NCAPD2", "NCAPH", "NCBP1", "NCBP2", "NCDN", "NCKAP1", "NCL", "NCLN", "NCOA5", "NCSTN", "NDC1", "NDUFA10", "NDUFA11", "NDUFA13", "NDUFA4", "NDUFA7", "NDUFA8", "NDUFA9", "NDUFAF4", "NDUFB11", "NDUFB4", "NDUFB5", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS8", "NDUFV1", "NDUFV2", "NECAP2", "NEFL", "NEFM", "NELFA", "NELFCD", "NELFE", "NEMF", "NES", "NFKB1", "NFS1", "NHLRC2", "NIFK", "NIP7", "NIPSNAP2", "NISCH", "NKRF", "NKTR", "NLE1", "NLN", "NMD3", "NME1", "NME2", "NMT1", "NNT", "NOC2L", "NOC3L", "NOC4L", "NOL10", "NOL11", "NOL6", "NOL7", "NOL8", "NOL9", "NOLC1", "NONO", "NOP10", "NOP14", "NOP16", "NOP2", "NOP56", "NOP58", "NOP9", "NOSIP", "NPC1", "NPEPPS", "NPLOC4", "NPM1", "NRBP1", "NRDC", "NSA2", "NSD2", "NSDHL", "NSF", "NSFL1C", "NSUN2", "NSUN5", "NT5DC1", "NTMT1", "NTPCR", "NUB1", "NUBP2", "NUBPL", "NUCB1", "NUCB2", "NUCKS1", "NUDC", "NUDCD1", "NUDCD2", "NUDT1", "NUDT21", "NUDT5", "NUDT9", "NUFIP2", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP188", "NUP35", "NUP37", "NUP50", "NUP54", "NUP62", "NUP85", "NUP88", "NVL", "NXF1", "NXN", "OAT", "OCIAD1", "OCLN", "OGDH", "OGT", "OLA1", "OPA1", "OPA3", "OSBP", "OSBPL11", "OSBPL6", "OSBPL8", "OSBPL9", "OSGEP", "OTUB1", "OXA1L", "P3H1", "P3H4", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PACSIN3", "PAF1", "PAFAH1B1", "PAFAH1B3", "PAICS", "PAK1", "PAK1IP1", "PAK2", "PALLD", "PANK4", "PAPSS1", "PARK7", "PARN", "PARP1", "PARP2", "PASK", "PBDC1", "PBK", "PBRM1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCID2", "PCK2", "PCLAF", "PCM1", "PCMT1", "PCNA", "PCNP", "PDAP1", "PDCD11", "PDCD4", "PDCD5", "PDCD6", "PDCD6IP", "PDCL3", "PDE4DIP", "PDHA1", "PDHB", "PDIA3", "PDIA4", "PDIA6", "PDK3", "PDLIM1", "PDLIM5", "PDLIM7", "PDS5A", "PDS5B", "PDXK", "PEBP1", "PECR", "PEF1", "PELO", "PELP1", "PEPD", "PES1", "PEX14", "PEX19", "PEX5", "PFAS", "PFDN2", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PGAM1", "PGAM5", "PGD", "PGLS", "PGM1", "PGM2", "PGP", "PGRMC1", "PGRMC2", "PHB", "PHB2", "PHF5A", "PHF6", "PHF8", "PHGDH", "PI4K2A", "PI4KB", "PICALM", "PIH1D1", "PIN1", "PIN4", "PINX1", "PIP4K2C", "PIR", "PISD", "PITPNA", "PITPNB", "PITRM1", "PKM", "PKMYT1", "PKN1", "PKN2", "PLA2G15", "PLAA", "PLCG1", "PLD3", "PLEC", "PLIN3", "PLOD1", "PLOD2", "PLRG1", "PLS3", "PM20D2", "PMPCA", "PMPCB", "PNN", "PNO1", "PNP", "PNPLA8", "PNPT1", "POFUT1", "POGZ", "POLA1", "POLA2", "POLD1", "POLDIP2", "POLDIP3", "POLE", "POLE3", "POLE4", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2B", "POLR2C", "POLR2E", "POLR2G", "POLR2L", "POLR3A", "POLRMT", "POP1", "POR", "PPA1", "PPA2", "PPAT", "PPFIA1", "PPIB", "PPID", "PPIE", "PPIF", "PPIL1", "PPIL4", "PPM1G", "PPME1", "PPOX", "PPP1CA", "PPP1CB", "PPP1R10", "PPP1R12A", "PPP1R7", "PPP1R8", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP4R3A", "PPP5C", "PPT1", "PPT2", "PQBP1", "PRAF2", "PRC1", "PRCC", "PRCP", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PREP", "PRIM2", "PRKACA", "PRKAG1", "PRKAR1A", "PRKCSH", "PRKDC", "PRKRA", "PRMT1", "PRMT5", "PRMT9", "PRPF19", "PRPF3", "PRPF31", "PRPF39", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPS2", "PRPSAP1", "PRPSAP2", "PRRC1", "PRRC2A", "PRRC2C", "PSAP", "PSAT1", "PSIP1", "PSMA1", "PSMA4", "PSMA5", "PSMA6", "PSMB1", "PSMB2", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD12", "PSMD13", "PSMD14", "PSMD3", "PSMD4", "PSMD7", "PSMD8", "PSME1", "PSME2", "PSME3", "PSME4", "PSMF1", "PSMG1", "PSPC1", "PTBP1", "PTBP2", "PTCD1", "PTCD3", "PTDSS1", "PTGES2", "PTGES3", "PTGR2", "PTPA", "PTPN1", "PTRH2", "PTRHD1", "PUF60", "PUM1", "PUM3", "PUS7", "PWP1", "PWP2", "PYCR2", "PYGB", "PYGL", "QARS", "QDPR", "QKI", "QRSL1", "RAB11B", "RAB13", "RAB14", "RAB1A", "RAB1B", "RAB24", "RAB3GAP1", "RAB3GAP2", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RAB8A", "RAB9A", "RABEP1", "RABEPK", "RABGAP1", "RAC1", "RACK1", "RAD21", "RAD23A", "RAD23B", "RAD50", "RAD9A", "RAE1", "RAI14", "RALA", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP9", "RANGAP1", "RAP1GDS1", "RAPGEF2", "RARS", "RARS2", "RAVER1", "RBBP5", "RBBP6", "RBM10", "RBM12", "RBM12B", "RBM14", "RBM17", "RBM19", "RBM22", "RBM25", "RBM26", "RBM27", "RBM28", "RBM3", "RBM34", "RBM39", "RBM4", "RBM42", "RBM4B", "RBM5", "RBM8A", "RBMX", "RBMXL1", "RBPMS", "RCC1", "RCL1", "RCN1", "RCN2", "RDH13", "RDH14", "RDX", "RECQL", "REEP5", "REPS1", "RER1", "RETSAT", "REXO2", "REXO4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RFX1", "RHOA", "RIC8A", "RIF1", "RINT1", "RIOX2", "RIPK1", "RMDN1", "RNASEH2A", "RNF14", "RNF20", "RNF219", "RNF40", "RNH1", "RNPEP", "RNPS1", "ROCK2", "RP2", "RPA1", "RPA2", "RPAP1", "RPAP3", "RPF2", "RPL10", "RPL10A", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL32", "RPL34", "RPL35", "RPL36", "RPL36A", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPN1", "RPN2", "RPP30", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS28", "RPS3", "RPS3A", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPSA", "RRBP1", "RRM1", "RRM2", "RRP1", "RRP12", "RRP15", "RRP1B", "RRP8", "RRS1", "RSF1", "RSL1D1", "RSU1", "RTCB", "RTN2", "RTN3", "RTN4", "RTRAF", "RUFY1", "RUVBL1", "RUVBL2", "S100A10", "S100A11", "S100A13", "SACM1L", "SAE1", "SAFB", "SAFB2", "SAMHD1", "SAMM50", "SAP130", "SAP18", "SAR1A", "SARNP", "SARS", "SARS2", "SART1", "SART3", "SBDS", "SC5D", "SCAF1", "SCAF4", "SCAMP1", "SCAMP2", "SCAMP3", "SCARB1", "SCARB2", "SCCPDH", "SCD", "SCML2", "SCO2", "SCP2", "SCPEP1", "SCRIB", "SCRN1", "SDF4", "SDHA", "SDHB", "SEC11A", "SEC16A", "SEC23A", "SEC23B", "SEC23IP", "SEC24A", "SEC24B", "SEC24C", "SEC31A", "SEC61A1", "SEC61B", "SEC62", "SEC63", "SENP3", "SEPHS1", "SEPT11", "SEPT2", "SEPT7", "SEPT9", "SERBP1", "SERPINB6", "SERPINH1", "SET", "SETD2", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFSWAP", "SFXN1", "SFXN4", "SGPL1", "SGTA", "SH3BGRL3", "SH3GL1", "SH3GLB1", "SH3GLB2", "SHCBP1", "SHMT1", "SHMT2", "SHOC2", "SHTN1", "SIRT1", "SKIV2L", "SKIV2L2", "SKP1", "SKP2", "SLC16A1", "SLC19A1", "SLC1A5", "SLC25A10", "SLC25A12", "SLC25A13", "SLC25A17", "SLC25A20", "SLC25A22", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A4", "SLC2A1", "SLC33A1", "SLC35B2", "SLC35F2", "SLC3A2", "SLC9A3R1", "SLFN11", "SLIRP", "SLK", "SLTM", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCC1", "SMARCC2", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC6", "SMCHD1", "SMN1*", "SMNDC1", "SMPD4", "SMU1", "SMYD3", "SMYD4", "SNAP23", "SNAP29", "SND1", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPC", "SNRPD2", "SNRPD3", "SNW1", "SNX1", "SNX17", "SNX2", "SNX27", "SNX5", "SNX6", "SNX9", "SOAT1", "SOD2", "SON", "SORD", "SORT1", "SPAG9", "SPART", "SPATA5L1", "SPC24", "SPC25", "SPCS2", "SPECC1L", "SPEN", "SPPL2A", "SPR", "SPTAN1", "SPTBN1", "SPTBN2", "SPTLC1", "SQLE", "SQSTM1", "SREK1", "SRI", "SRM", "SRP14", "SRP54", "SRP68", "SRPK1", "SRPRB", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF3", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSR1", "SSR4", "SSRP1", "STAG1", "STAG2", "STAM", "STAMBP", "STARD3", "STARD3NL", "STARD7", "STAT1", "STAT3", "STAU1", "STAU2", "STIP1", "STK4", "STMN1", "STOM", "STOML2", "STRAP", "STRN", "STUB1", "STX12", "STX18", "STX5", "STX7", "STXBP3", "STXBP4", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGP2", "SUGT1", "SUN1", "SUPT16H", "SUPT5H", "SUPT6H", "SUPV3L1", "SURF4", "SURF6", "SUZ12", "SV2A", "SYAP1", "SYMPK", "SYNCRIP", "SYNE2", "SYNGR2", "SYNJ2BP", "TACC3", "TAF15", "TAGLN2", "TALDO1", "TAMM41", "TARDBP", "TARS", "TARS2", "TBC1D13", "TBC1D15", "TBC1D4", "TBC1D9B", "TBCA", "TBCC", "TBL3", "TBRG4", "TCAF1", "TCEA1", "TCERG1", "TCOF1", "TDP2", "TDRKH", "TECR", "TELO2", "TERF2IP", "TEX10", "TEX264", "TFAM", "TFCP2", "TFG", "TFRC", "THOC1", "THOC2", "THOC3", "THOC6", "THOP1", "THRAP3", "THUMPD1", "THUMPD3", "TIA1", "TIAL1", "TIGAR", "TIMM10", "TIMM17A", "TIMM17B", "TIMM23", "TIMM44", "TIMM50", "TIPRL", "TJP1", "TKFC", "TKT", "TLN1", "TM9SF3", "TMA16", "TMCO1", "TMED10", "TMED2", "TMEM104", "TMEM109", "TMEM126A", "TMEM165", "TMEM192", "TMEM201", "TMEM205", "TMEM209", "TMEM214", "TMEM230", "TMEM41A", "TMEM97", "TMOD3", "TMX1", "TMX2", "TMX4", "TNKS1BP1", "TNPO1", "TNPO2", "TNPO3", "TOE1", "TOLLIP", "TOMM20", "TOMM22", "TOMM34", "TOMM40", "TOMM5", "TOMM70", "TOP1", "TOP2A", "TOP2B", "TOR1AIP1", "TOX4", "TP53", "TP53BP1", "TPD52", "TPD52L2", "TPI1", "TPM1", "TPM3", "TPM4", "TPP2", "TPR", "TPT1", "TPX2", "TRA2A", "TRA2B", "TRABD", "TRAP1", "TRAPPC5", "TRIM21", "TRIM24", "TRIM25", "TRIM26", "TRIM27", "TRIM28", "TRIM33", "TRIM35", "TRIP12", "TRIP13", "TRIR", "TRMT10C", "TRMT1L", "TROVE2", "TSFM", "TSG101", "TSN", "TSNAX", "TSPAN3", "TSPAN6", "TSR1", "TTC1", "TTC19", "TTC37", "TTC38", "TTC4", "TTF2", "TTLL12", "TUBB", "TUBB2A", "TUBB2B", "TUBB4A", "TUBB4B", "TUBB6", "TUBGCP2", "TUFM", "TWF1", "TWF2", "TXLNA", "TXLNG", "TXNDC5", "TXNL1", "TXNRD1", "U2AF1", "U2AF2", "U2SURP", "UAP1", "UBA1", "UBA2", "UBA3", "UBA6", "UBAP2", "UBAP2L", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2O", "UBE2S", "UBE3A", "UBFD1", "UBLCP1", "UBQLN4", "UBR4", "UBR5", "UBTF", "UBXN1", "UCHL5", "UFC1", "UFD1", "UFL1", "UGDH", "UGGT1", "UGP2", "UHRF1", "UMPS", "UNC45A", "UNG", "UPF1", "UQCC1", "UQCRC1", "UQCRC2", "UQCRQ", "URB1", "UROD", "USMG5", "USO1", "USP10", "USP11", "USP14", "USP15", "USP39", "USP47", "USP48", "USP5", "USP7", "USP9X", "UTP11", "UTP14A", "UTP15", "UTP18", "UTP20", "UTP3", "UTP4", "UTP6", "UTRN", "VAMP7", "VANGL1", "VAPA", "VAPB", "VARS1", "VARS2", "VBP1", "VCL", "VCP", "VDAC2", "VDAC3", "VIM", "VIRMA", "VKORC1L1", "VMP1", "VPS26A", "VPS29", "VPS33A", "VPS35", "VPS4B", "VRK1", "VTA1", "VTI1B", "WAPL", "WARS", "WASHC4", "WBP11", "WBP2", "WDHD1", "WDR1", "WDR18", "WDR3", "WDR36", "WDR41", "WDR46", "WDR5", "WDR6", "WDR61", "WDR77", "WDR82", "WIPI2", "WIZ", "WNK1", "WTAP", "XAB2", "XPNPEP1", "XPNPEP3", "XPO1", "XPO5", "XPOT", "XRCC1", "XRCC5", "XRCC6", "XRN2", "YARS", "YARS2", "YBX1", "YBX3", "YEATS4", "YKT6", "YLPM1", "YME1L1", "YRDC", "YTHDC1", "YTHDC2", "YTHDF2", "YWHAB", "YWHAE", "YWHAG", "YWHAQ", "ZADH2", "ZC3H11A", "ZC3H14", "ZC3H15", "ZC3H18", "ZC3H7A", "ZC3HAV1", "ZC3HC1", "ZCCHC3", "ZCCHC8", "ZFR", "ZFYVE16", "ZMYM2", "ZNF207", "ZNF24", "ZNF281", "ZNF318", "ZNF326", "ZNF622", "ZNF638", "ZPR1", "ZW10", "ZYX"], "leading_proteins": ["AARS2", "ABCB1", "ABCB7", "ABHD10", "ACAD9", "ACOT8", "ACOX3", "ACSL4", "AKT2", "ALDH3A2", "ALG1", "ANKLE2", "APC", "APOOL", "APP", "ATAD1", "ATAD3A", "ATAD3B", "ATP13A1", "ATP5L", "ATP6V0A1", "ATP6V0A2", "BCAP31", "BICD2", "BLVRB", "BNIP1", "BRI3BP", "BTAF1", "C11orf58", "C12orf73", "CALU", "CCDC47", "CDK4", "CERS1", "CERS2", "CHID1", "CHKA", "CHST14", "CISD1", "CLCC1", "CLCN3", "CLPTM1", "CLPTM1L", "CLUH", "COA3", "COMT", "COPB2", "COX15", "COX4I1", "CPD", "CPOX", "CPT2", "CTSC", "CUTA", "CYB5B", "CYB5D2", "CYP51A1", "DCUN1D4", "DERL1", "DHCR7", "DNAJA2", "DNM2", "DOLPP1", "DUSP9", "DYNC1I2", "EBP", "ECH1", "EMD", "ENDOD1", "ERGIC2", "FAM114A2", "FAM162A", "FAM8A1", "FDFT1", "FKBP14", "FKBP7", "GDAP1", "GHITM", "GLG1", "GLUD1", "GOLIM4", "GOLPH3", "GOLT1B", "GPAM", "GPD2", "GPR107", "GPR108", "GUSB", "GYG1", "HACD3", "HADH", "HADHA", "HDHD3", "HEBP1", "HM13", "HMOX1", "HMOX2", "HS2ST1", "HSDL1", "IKBIP", "ILVBL", "INA", "IPO9", "ITCH", "KDELR1", "KIAA0319L", "KIAA2013", "KLC2", "LBR", "LETM1", "MAIP1", "MCCC2", "MFN1", "MIA2", "MICU2", "MIPEP", "MMAB", "MPP2", "MRPL20", "MRPL39", "MRPS9", "MSMO1", "MTDH", "MTFP1", "MTX1", "MTX2", "MXRA7", "NDC1", "NDUFA11", "NDUFA13", "NDUFB11", "NDUFB4", "NDUFB9", "NDUFS2", "NEFL", "NEFM", "NELFCD", "NES", "NIPSNAP2", "NNT", "NPC1", "NUCB1", "NUCB2", "NUP107", "OCIAD1", "OPA1", "OSBP", "OXA1L", "P3H1", "P3H4", "P4HA1", "PDK3", "PECR", "PEX14", "PEX5", "PGRMC1", "PITRM1", "PKMYT1", "PLA2G15", "PLD3", "PMPCA", "POR", "PPT1", "PRCP", "PREB", "PSAP", "PSMB4", "PTDSS1", "PTGES2", "QRSL1", "RAB24", "RCN2", "REEP5", "RINT1", "RPL36A", "RPL8", "RPS23", "RPS3", "RTN3", "RTN4", "SAR1A", "SC5D", "SCAMP1", "SCAMP2", "SCARB1", "SCCPDH", "SCD", "SDF4", "SDHB", "SEC11A", "SEC16A", "SEC24B", "SEC62", "SFXN4", "SGPL1", "SLC25A10", "SLC25A20", "SLC25A26", "SLC25A32", "SLC25A6", "SLC35B2", "SLC35F2", "SMYD4", "SORT1", "SPTLC1", "SQLE", "SSR1", "STARD3NL", "STARD7", "STX18", "STX5", "SURF4", "SYNCRIP", "SYNGR2", "SYNJ2BP", "TECR", "TIAL1", "TIMM10", "TIMM17A", "TIMM17B", "TIMM23", "TIMM44", "TM9SF3", "TMCO1", "TMEM104", "TMEM165", "TMEM201", "TMEM205", "TMEM209", "TMEM214", "TMEM230", "TMEM97", "TMX1", "TMX4", "TOMM22", "TOMM40", "TOMM5", "TRA2A", "TRABD", "TSN", "TSPAN3", "UQCRQ", "USMG5", "USP47", "VAMP7", "VDAC2", "VDAC3", "VIM", "VKORC1L1", "VMP1", "VTI1B", "YBX1", "YEATS4", "ZADH2", "ZNF326", "ZNF622", "ZPR1"]} \ No newline at end of file