diff --git a/interpro_active_site/advanced/idx2term.json b/interpro_active_site/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..9e26dfeeb6e641a33dae4961196235bdb965b21b --- /dev/null +++ b/interpro_active_site/advanced/idx2term.json @@ -0,0 +1 @@ +{} \ No newline at end of file diff --git a/interpro_active_site/basic/idx2term.json b/interpro_active_site/basic/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..9e26dfeeb6e641a33dae4961196235bdb965b21b --- /dev/null +++ b/interpro_active_site/basic/idx2term.json @@ -0,0 +1 @@ +{} \ No newline at end of file diff --git a/interpro_active_site/consensus.joblib b/interpro_active_site/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..5cdd5303832ee7618d07f8dfccb4f018044a276e --- /dev/null +++ b/interpro_active_site/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:ebcab3ddfcead15dcc8cbf8fea0e6f03d43acd7e4760a52fe4e8f2e3d10d2c67 +size 62961 diff --git a/interpro_active_site/df_merge.tsv b/interpro_active_site/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..c57981107d970e936c6c67aa07afef8fff633223 --- /dev/null +++ b/interpro_active_site/df_merge.tsv @@ -0,0 +1 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 diff --git a/interpro_active_site/metrics.json b/interpro_active_site/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..70a9e24dec639ea006d03256de8c5c5618391a4d --- /dev/null +++ b/interpro_active_site/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2644, + "annotations_size": 53, + "title": "Average number of proteins per term", + "value": 2.452830188679245 +} \ No newline at end of file diff --git a/interpro_active_site/paths.json b/interpro_active_site/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..caaafec24ec7219272ed5394927d1f096cf80377 --- /dev/null +++ b/interpro_active_site/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/interpro_active_site/fragment/C197/C197_val_log2fc"} \ No newline at end of file diff --git a/interpro_active_site/result.tsv b/interpro_active_site/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..52139809efc0b93e5089d38b361205d3a0b23e61 --- /dev/null +++ b/interpro_active_site/result.tsv @@ -0,0 +1,6 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Serine carboxypeptidase, serine active site [IPR018202] 0.96895115486558 2.025622031583909 0.0428035320636541 0.9015858305052008 0.2423560950063112 3 P10619,Q9HB40 2 +Cysteine peptidase, asparagine active site [IPR025661] 0.9678274034822096 1.6054864449286408 0.1083867939046254 0.997712536901202 0.2735476227116737 2 P07858 1 +Cysteine peptidase, histidine active site [IPR025660] 0.9678274034822096 1.6054864449286408 0.1083867939046254 0.997712536901202 0.2735476227116737 2 P07858 1 +Cysteine peptidase, cysteine active site [IPR000169] 0.6836532573572689 1.3235651481482615 0.1856475063388796 0.9999812475152506 0.3392868219296765 5 P07858 1 +Tyrosine-protein kinase, active site [IPR008266] 0.6741106120351807 0.8504098828058042 0.3950972434941238 0.9999999999973126 0.5890988630099769 3 Q15375 1 diff --git a/interpro_active_site/selections.json b/interpro_active_site/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..545a6bd82a8b6a7fa764a59d317426d45638ae29 --- /dev/null +++ b/interpro_active_site/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["ATP synthase, F0 complex, subunit A, active site [IPR023011]", "ATP-citrate lyase/succinyl-CoA ligase, active site [IPR017440]", "ATP:guanido phosphotransferase active site [IPR022415]", "ATPase, alpha/beta subunit, nucleotide-binding domain, active site [IPR020003]", "Adenylosuccinate synthase, active site [IPR033128]", "Beta-ketoacyl synthase, active site [IPR018201]", "Citrate synthase active site [IPR019810]", "ClpP, Ser active site [IPR018215]", "ClpP, histidine active site [IPR033135]", "Cysteine peptidase, asparagine active site [IPR025661]", "Cysteine peptidase, cysteine active site [IPR000169]", "Cysteine peptidase, histidine active site [IPR025660]", "DNA methylase, C-5 cytosine-specific, active site [IPR018117]", "DNA topoisomerase I, active site [IPR018521]", "Ferrochelatase, active site [IPR019772]", "Glucose-6-phosphate dehydrogenase, active site [IPR019796]", "Glutaredoxin active site [IPR011767]", "Glyceraldehyde 3-phosphate dehydrogenase, active site [IPR020830]", "Glycoside hydrolase, family 2, active site [IPR023232]", "Glycosyl hydrolases family 18 (GH18) active site [IPR001579]", "Glycosyl hydrolases family 31, active site [IPR030458]", "Histidine acid phosphatase active site [IPR033379]", "Hydroxymethylglutaryl-coenzyme A synthase, active site [IPR000590]", "L-lactate dehydrogenase, active site [IPR018177]", "Leu/Phe/Val dehydrogenases active site [IPR033524]", "Malate dehydrogenase, active site [IPR001252]", "Nucleoside diphosphate kinase, active site [IPR023005]", "Orotidine 5'-phosphate decarboxylase, active site [IPR018089]", "Peptidase S16, active site [IPR008268]", "Peptidase S26A, signal peptidase I, serine active site [IPR019756]", "Peptidase S8, subtilisin, His-active site [IPR022398]", "Peptidase S8, subtilisin, Ser-active site [IPR023828]", "Peptidase S9, serine active site [IPR002471]", "Phosphoglycerate/bisphosphoglycerate mutase, active site [IPR001345]", "Phosphoribosylglycinamide formyltransferase, active site [IPR001555]", "Protein-tyrosine phosphatase, active site [IPR016130]", "Pyridine nucleotide-disulphide oxidoreductase, class I, active site [IPR012999]", "Pyruvate kinase, active site [IPR018209]", "Ribonuclease T2, His active site 1 [IPR018188]", "Ribonuclease T2, His active site 2 [IPR033130]", "Ribonucleotide reductase small subunit, acitve site [IPR030475]", "Serine carboxypeptidase, serine active site [IPR018202]", "Serine carboxypeptidases, histidine active site [IPR033124]", "Serine/threonine-protein kinase, active site [IPR008271]", "Thermonuclease active site [IPR002071]", "Thiolase, active site [IPR020610]", "Thiolase, acyl-enzyme intermediate active site [IPR020615]", "Thymidylate synthase, active site [IPR020940]", "Transaldolase, active site [IPR018225]", "Triosephosphate isomerase, active site [IPR020861]", "Tyrosine-protein kinase, active site [IPR008266]", "Ubiquitin-activating enzyme E1, Cys active site [IPR033127]", "Ubiquitin-conjugating enzyme, active site [IPR023313]"], "available_proteins": ["ACAA2", "ACAT1", "ACAT2", "ACLY", "ACP2", "ACP6", "ADSS", "AKT2", "APEH", "ATP5A1", "ATP5B", "ATP6", "ATP6V1A", "ATP6V1B2", "AURKA", "BLMH", "CAMK1", "CAMK2G", "CAPN1", "CAPN2", "CDC34", "CDK1", "CDK2", "CDK4", "CDK5", "CDK6", "CHUK", "CKB", "CKMT1A*", "CLPP", "CPVL", "CS", "CSK", "CSNK1A1", "CSNK2A1", "CSNK2A2", "CTBS", "CTSA", "CTSB", "CTSC", "DLD", "DNMT1", "DUSP3", "EIF2AK2", "EPHA7", "FASN", "FECH", "G6PD", "GAA", "GAK", "GANAB", "GAPDH", "GART", "GLRX", "GLUD1", "GSK3B", "GSR", "GUSB", "HADHB", "HMGCS1", "LDHA", "LDHB", "LONP1", "MAP2K1", "MAPK1", "MDH1", "MDH2", "MTMR2", "MTMR6", "NEK9", "NME1", "NME6", "PAK1", "PAK2", "PBK", "PGAM1", "PIK3R4", "PKM", "PKMYT1", "PKN2", "PLK1", "PREP", "PRKCD", "PRPF4B", "PTK7", "PTPN1", "PTPN11", "RNASET2", "ROCK1", "ROCK2", "RPS6KA1", "RPS6KA3", "RRM2", "SCP2", "SCPEP1", "SEC11A", "SLK", "SND1", "SRPK1", "SUCLG1", "TALDO1", "TIGAR", "TOP1", "TPI1", "TPP2", "TRIO", "TTK", "TXNRD1", "TYMS", "UBA1", "UBA2", "UBA3", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2S", "UMPS", "VRK1"], "leading_proteins": ["CTSA", "CTSB", "EPHA7", "SCPEP1"]} \ No newline at end of file diff --git a/interpro_binding_site/advanced/idx2term.json b/interpro_binding_site/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..9e26dfeeb6e641a33dae4961196235bdb965b21b --- /dev/null +++ b/interpro_binding_site/advanced/idx2term.json @@ -0,0 +1 @@ +{} \ No newline at end of file diff --git a/interpro_binding_site/basic/idx2term.json b/interpro_binding_site/basic/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..1f2df466d020a9613ebb803cec2bf89e8e4d80ca --- /dev/null +++ b/interpro_binding_site/basic/idx2term.json @@ -0,0 +1 @@ +{"0": "EF-Hand 1, calcium-binding site [IPR018247]"} \ No newline at end of file diff --git a/interpro_binding_site/basic/plot_0.png b/interpro_binding_site/basic/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..4b9abc5d50e9b14206783208d98d4cd0ded3cc27 --- /dev/null +++ b/interpro_binding_site/basic/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:972ed192ad5516923a730eab27ae3d97c3fced55c2d0831e9e4913ca62212f99 +size 139963 diff --git a/interpro_binding_site/consensus.joblib b/interpro_binding_site/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..0cdb6fcd144d093e3e654dd26a67af2ca8f3dbe6 --- /dev/null +++ b/interpro_binding_site/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:8dceb74b8a1e02fbfe6ef5b0c3e0e77b8a6cf9e48323c3e0f8dd9adb2fe463f3 +size 59682 diff --git a/interpro_binding_site/df_merge.tsv b/interpro_binding_site/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..c57981107d970e936c6c67aa07afef8fff633223 --- /dev/null +++ b/interpro_binding_site/df_merge.tsv @@ -0,0 +1 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 diff --git a/interpro_binding_site/metrics.json b/interpro_binding_site/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..902036351d83305202c399cfaf61571a79afbe0d --- /dev/null +++ b/interpro_binding_site/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2644, + "annotations_size": 27, + "title": "Average number of proteins per term", + "value": 4.555555555555555 +} \ No newline at end of file diff --git a/interpro_binding_site/paths.json b/interpro_binding_site/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..3fce33fad6c5d1b6477385a37cd0ebe548d5e986 --- /dev/null +++ b/interpro_binding_site/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/interpro_binding_site/fragment/C197/C197_val_log2fc"} \ No newline at end of file diff --git a/interpro_binding_site/result.tsv b/interpro_binding_site/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..87ec46afb127667d5e53c15d47d6e7b6b84e1814 --- /dev/null +++ b/interpro_binding_site/result.tsv @@ -0,0 +1,6 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Peptidase M16, zinc-binding site [IPR001431] 0.550204081932839 0.7504411896985915 0.4529890312535802 0.9999999156873104 0.7644189902404167 5 Q10713 1 +Aminotransferase, class-II, pyridoxal-phosphate binding site [IPR001917] 0.7214231642694893 0.6358794443507858 0.5248550014985356 0.9999999981193568 0.8335932376741447 2 O15270 1 +Serine hydroxymethyltransferase, pyridoxal phosphate binding site [IPR019798] 0.6797880393641134 0.4966097397257876 0.6194642834950328 0.9999999999953152 0.8363335406030687 2 P34896 1 +EF-Hand 1, calcium-binding site [IPR018247] 0.3562309814657868 0.2721992167303835 0.7854688440664694 1.0 0.9343449204584972 38 P80303,Q14257,O43852,Q9Y680,Q02818 5 +Hexokinase, binding site [IPR019807] 0.3050719152157387 0.0386802528548032 0.9691453175646784 1.0 0.9691453175646784 2 P52789 1 diff --git a/interpro_binding_site/selections.json b/interpro_binding_site/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..7407459a383ce4f11b276e08d3b888c4804f74ee --- /dev/null +++ b/interpro_binding_site/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["2-oxo acid dehydrogenase, lipoyl-binding site [IPR003016]", "2Fe-2S ferredoxin, iron-sulphur binding site [IPR006058]", "6-phosphogluconate-binding site [IPR006184]", "AP endonuclease 1, binding site [IPR020847]", "Aconitase family, 4Fe-4S cluster binding site [IPR018136]", "Adenylosuccinate synthase, GTP-binding site [IPR018220]", "Aminotransferase class-V, pyridoxal-phosphate binding site [IPR020578]", "Aminotransferase, class-II, pyridoxal-phosphate binding site [IPR001917]", "Aminotransferases, class-I, pyridoxal-phosphate-binding site [IPR004838]", "Beta tubulin, autoregulation binding site [IPR013838]", "Biotin-binding site [IPR001882]", "Copper centre Cu(A) [IPR001505]", "Cytochrome b5, heme-binding site [IPR018506]", "EF-Hand 1, calcium-binding site [IPR018247]", "Fumarate reductase/succinate dehydrogenase, FAD-binding site [IPR003952]", "Hexokinase, binding site [IPR019807]", "IQ motif, EF-hand binding site [IPR000048]", "Inositol monophosphatase, metal-binding site [IPR020583]", "Manganese/iron superoxide dismutase, binding site [IPR019833]", "PPM-type phosphatase, divalent cation binding [IPR000222]", "Peptidase M16, zinc-binding site [IPR001431]", "Peptidase M24A, methionine aminopeptidase, subfamily 2, binding site [IPR018349]", "Porphobilinogen deaminase, dipyrromethane cofactor binding site [IPR022419]", "Protein kinase, ATP binding site [IPR017441]", "Serine hydroxymethyltransferase, pyridoxal phosphate binding site [IPR019798]", "Sigma-54 interaction domain, ATP-binding site 1 [IPR025662]", "Transketolase binding site [IPR020826]"], "available_proteins": ["ACACA", "ACO2", "ACTN1", "ACTN4", "ADSS", "AKT2", "APEX1", "APEX2", "AURKA", "BPNT1", "CALM3", "CALU", "CAMK1", "CAMK2G", "CAPN1", "CAPN2", "CAPNS1", "CDK1", "CDK2", "CDK4", "CDK5", "CDK6", "CETN2", "CHUK", "COX2", "CSK", "CSNK1A1", "CSNK2A1", "CSNK2A2", "CYB5B", "DLAT", "DLST", "DST", "EHD1", "EHD4", "EIF2AK2", "EPHA7", "EPS15", "EPS15L1", "FKBP10", "FKBP14", "FKBP7", "GCAT", "GOT1", "GOT2", "GPD2", "GSK3B", "HK1", "HK2", "HMBS", "IDE", "ILKAP", "IQGAP1", "LETM1", "MACF1", "MAP2K1", "MAPK1", "MCCC1", "MICU1", "MYH10", "MYH14", "MYH9", "MYO1B", "MYO1C", "MYO1D", "NRDC", "NUCB1", "NUCB2", "OXSR1", "PA2G4", "PAK1", "PAK2", "PC", "PCCA", "PDCD6", "PEF1", "PGD", "PKMYT1", "PKN2", "PLCG1", "PLK1", "PLS3", "PMPCA", "PMPCB", "PPM1G", "PRKCD", "PRKCSH", "PSAT1", "RAB18", "RCN1", "RCN2", "REPS1", "RHOT1", "RHOT2", "ROCK1", "ROCK2", "RPS6KA1", "RPS6KA3", "S100A11", "SDF4", "SDHA", "SDHB", "SHMT1", "SHMT2", "SLC25A12", "SLC25A24", "SLK", "SOD2", "SPTAN1", "SPTLC2", "SRI", "SRPK1", "TKT", "TTK", "TUBB", "TUBB2A", "TUBB2B", "TUBB4A", "TUBB4B", "TUBB6", "UBE3C", "UQCRC2", "VRK1"], "leading_proteins": ["CALU", "FKBP7", "HK2", "NUCB1", "NUCB2", "PMPCA", "RCN2", "SHMT1", "SPTLC2"]} \ No newline at end of file diff --git a/interpro_conserved_site/advanced/idx2term.json b/interpro_conserved_site/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..9e26dfeeb6e641a33dae4961196235bdb965b21b --- /dev/null +++ b/interpro_conserved_site/advanced/idx2term.json @@ -0,0 +1 @@ +{} \ No newline at end of file diff --git a/interpro_conserved_site/basic/idx2term.json b/interpro_conserved_site/basic/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..c2d87a456c859f7d763df70f2e8915263713ecf7 --- /dev/null +++ b/interpro_conserved_site/basic/idx2term.json @@ -0,0 +1 @@ +{"0": "Proteasome beta-type subunit, conserved site [IPR016050]"} \ No newline at end of file diff --git a/interpro_conserved_site/basic/plot_0.png b/interpro_conserved_site/basic/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..43529c334d82c4c99ec4642c1e2dc75f645ef0a3 --- /dev/null +++ b/interpro_conserved_site/basic/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:f32abd7c9a0fd5833e016dbbc6c50f444bc33c49a2e21c4bcaeb65608cc59884 +size 138489 diff --git a/interpro_conserved_site/consensus.joblib b/interpro_conserved_site/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..7a4964c01ac45464df7395cd375e3ae3ed920b51 --- /dev/null +++ b/interpro_conserved_site/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:110612cbeae940bc8c48ff0c86e720f35e4a21d67f67b9c5f32b65d3d56a4bb2 +size 63794 diff --git a/interpro_conserved_site/df_merge.tsv b/interpro_conserved_site/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..c57981107d970e936c6c67aa07afef8fff633223 --- /dev/null +++ b/interpro_conserved_site/df_merge.tsv @@ -0,0 +1 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 diff --git a/interpro_conserved_site/metrics.json b/interpro_conserved_site/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..92e3bd9a1001e86d391ac3c66f8acfaf84cf802c --- /dev/null +++ b/interpro_conserved_site/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2644, + "annotations_size": 265, + "title": "Average number of proteins per term", + "value": 2.4754716981132074 +} \ No newline at end of file diff --git a/interpro_conserved_site/paths.json b/interpro_conserved_site/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..aeecfc0064c0c7595ac81105e84e29729a3fb077 --- /dev/null +++ b/interpro_conserved_site/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/interpro_conserved_site/fragment/C197/C197_val_log2fc"} \ No newline at end of file diff --git a/interpro_conserved_site/result.tsv b/interpro_conserved_site/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..2a2870de9a2cd65e955d394ff273cf905a4edea1 --- /dev/null +++ b/interpro_conserved_site/result.tsv @@ -0,0 +1,19 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Proteasome beta-type subunit, conserved site [IPR016050] 0.7561484137832274 1.9447159348381005 0.0518091766137511 0.9999992459967963 0.5562678490990643 8 P20618,Q99436,P49720,P49721,P28072,P28070 6 +Immunoglobulin/major histocompatibility complex, conserved site [IPR003006] 0.9341158652025732 1.8881764148678863 0.0590022709750188 0.9999998997758324 0.5562678490990643 3 P55899,P01889 2 +Tetraspanin, conserved site [IPR018503] 0.992429977289932 1.7061448728448674 0.0879811096363463 0.9999999999748224 0.5562678490990643 2 O43657 1 +Syntaxin/epimorphin, conserved site [IPR006012] 0.7988335802723473 1.6606998525033425 0.0967737430522515 0.9999999999980675 0.5562678490990643 4 O15400,Q9P2W9 2 +Amyloidogenic glycoprotein, copper-binding domain conserved site [IPR019744] 0.9746404239212711 1.6333779899592 0.1023895232075535 0.99999999999963 0.5562678490990643 2 P05067 1 +Proteinase inhibitor I2, Kunitz, conserved site [IPR020901] 0.9746404239212711 1.6333779899592 0.1023895232075535 0.99999999999963 0.5562678490990643 2 P05067 1 +Amyloidogenic glycoprotein, intracellular domain, conserved site [IPR019745] 0.9746404239212711 1.6333779899592 0.1023895232075535 0.99999999999963 0.5562678490990643 2 P05067 1 +Glycoside hydrolase, family 29, conserved site [IPR018526] 0.9682059046177132 1.60703621727939 0.108046423516257 0.9999999999999308 0.5614176908197669 2 Q9BTY2 1 +Isocitrate/isopropylmalate dehydrogenase, conserved site [IPR019818] 0.7701371634676966 1.5411513637949172 0.123279951382424 0.9999999999999992 0.5731436336200418 4 P48735 1 +Sterol reductase, conserved site [IPR018083] 0.9333838001513992 1.464430138431451 0.1430764583892956 1.0 0.6072414577739758 2 Q9UBM7 1 +Chromo domain, conserved site [IPR023779] 0.6716774240018573 1.1279760621370991 0.2593300288024456 1.0 0.738951157340302 4 P45973,P83916 2 +Haem oxygenase conserved site [IPR018207] 0.8277819833459477 1.0368523369703433 0.2998046798528184 1.0 0.7872744429344776 2 P30519 1 +3-hydroxyacyl-CoA dehydrogenase, conserved site [IPR006180] 0.8118849356548048 0.9741390919397898 0.3299874818228634 1.0 0.7949698425732619 2 Q16836 1 +Acyl-CoA-binding protein, ACBP, conserved site [IPR022408] 0.7339137017411017 0.6800896718731139 0.4964476836801856 1.0 0.9342032980858536 2 O75521 1 +Profilin conserved site [IPR027310] 0.6616199848599492 0.4404156182303438 0.6596361151342682 1.0 0.9604591786295664 2 P35080 1 +Cadherin conserved site [IPR020894] 0.5231767518201947 0.3400572383522252 0.7338134236140064 1.0 0.9640891206444152 3 Q14574 1 +Ribosomal protein S9, conserved site [IPR020574] 0.4330052990158922 0.0589751132933608 0.9529719303163844 1.0 1.0 2 P82933 1 +Ribosomal protein S5, N-terminal, conserved site [IPR018192] 0.369417108251315 0.0426025975062169 0.9660183248613908 1.0 1.0 2 P82675 1 diff --git a/interpro_conserved_site/selections.json b/interpro_conserved_site/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..c310ab2c88b5daf01b07665bce217d4d2532180d --- /dev/null +++ b/interpro_conserved_site/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["14-3-3 protein, conserved site [IPR023409]", "3-hydroxyacyl-CoA dehydrogenase, conserved site [IPR006180]", "3-hydroxyisobutyrate dehydrogenase-related, conserved site [IPR002204]", "4Fe-4S ferredoxin, iron-sulphur binding, conserved site [IPR017900]", "ABC transporter-like, conserved site [IPR017871]", "AMP-binding, conserved site [IPR020845]", "AP endonuclease 1, conserved site [IPR020848]", "AT hook, DNA-binding motif [IPR017956]", "ATP synthase, F1 complex, gamma subunit conserved site [IPR023632]", "ATP-citrate lyase/succinyl-CoA ligase, conserved site [IPR033847]", "ATP-dependent RNA helicase DEAD-box, conserved site [IPR000629]", "ATPase, AAA-type, conserved site [IPR003960]", "ATPase, OSCP/delta subunit, conserved site [IPR020781]", "Acin1, RNSP1-SAP18 binding (RSB) motif [IPR032552]", "Actin, conserved site [IPR004001]", "Actin/actin-like conserved site [IPR020902]", "Actinin-type actin-binding domain, conserved site [IPR001589]", "Acyl-CoA dehydrogenase, conserved site [IPR006089]", "Acyl-CoA-binding protein, ACBP, conserved site [IPR022408]", "Adenylate kinase, conserved site [IPR033690]", "Alanine dehydrogenase/NAD(P) transhydrogenase, conserved site-1 [IPR008142]", "Alanine dehydrogenase/pyridine nucleotide transhydrogenase, conserved site-2 [IPR008143]", "Alcohol dehydrogenase, zinc-type, conserved site [IPR002328]", "Aldehyde dehydrogenase, cysteine active site [IPR016160]", "Aldehyde dehydrogenase, glutamic acid active site [IPR029510]", "Aldo/keto reductase, conserved site [IPR018170]", "Aldose 1-epimerase, conserved site [IPR018052]", "Alpha-D-phosphohexomutase, conserved site [IPR016066]", "Aminoacyl-tRNA synthetase, class I, conserved site [IPR001412]", "Amyloidogenic glycoprotein, copper-binding domain conserved site [IPR019744]", "Amyloidogenic glycoprotein, intracellular domain, conserved site [IPR019745]", "Annexin repeat, conserved site [IPR018252]", "Apoptosis regulator, Bcl-2, BH1 motif, conserved site [IPR020717]", "Apoptosis regulator, Bcl-2, BH2 motif, conserved site [IPR020726]", "Apoptosis regulator, Bcl-2, BH3 motif, conserved site [IPR020728]", "ArgE/DapE/ACY1/CPG2/YscS, conserved site [IPR001261]", "BUD31/G10-related, conserved site [IPR018230]", "Bacterial Fmu (Sun)/eukaryotic nucleolar NOL1/Nop2p, conserved site [IPR018314]", "Band 7/stomatin-like, conserved site [IPR018080]", "Bromodomain, conserved site [IPR018359]", "C-type lectin, conserved site [IPR018378]", "CAP, conserved site, C-terminal [IPR028417]", "CAP, conserved site, N-terminal [IPR018106]", "CBX family C-terminal motif [IPR033773]", "Cadherin conserved site [IPR020894]", "Calreticulin/calnexin, conserved site [IPR018124]", "Carbohydrate/purine kinase, PfkB, conserved site [IPR002173]", "Chaperonin Cpn60, conserved site [IPR018370]", "Chaperonin GroES, conserved site [IPR018369]", "Chaperonin TCP-1, conserved site [IPR002194]", "Chromo domain, conserved site [IPR023779]", "Clathrin adaptor complex, small chain [IPR000804]", "Clathrin adaptor, mu subunit, conserved site [IPR018240]", "Coproporphyrinogen III oxidase, conserved site [IPR018375]", "Cullin, conserved site [IPR016157]", "Cyclic nucleotide-binding, conserved site [IPR018488]", "Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site [IPR020892]", "Cytochrome P450, conserved site [IPR017972]", "D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site 1 [IPR029752]", "D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site [IPR029753]", "DNA ligase, ATP-dependent, conserved site [IPR016059]", "DNA methylase, C-5 cytosine-specific, conserved site [IPR031303]", "DNA mismatch repair, conserved site [IPR014762]", "DNA topoisomerase, type IIA, conserved site [IPR018522]", "DNA-directed DNA polymerase, family B, conserved site [IPR017964]", "DNA-directed RNA polymerase, 30-40kDa subunit, conserved site [IPR001514]", "DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site [IPR002464]", "Dihydrofolate reductase conserved site [IPR017925]", "Dihydroorotase, conserved site [IPR002195]", "DnaJ domain, conserved site [IPR018253]", "Dpy-30 motif [IPR007858]", "Dynamin, GTPase region, conserved site [IPR019762]", "Dynein light chain, type 1/2, conserved site [IPR019763]", "EGF-like calcium-binding, conserved site [IPR018097]", "EGF-like, conserved site [IPR013032]", "Electron transfer flavoprotein subunit alpha, conserved site [IPR018206]", "Electron transfer flavoprotein, beta-subunit, conserved site [IPR000049]", "Endonuclease III-like, conserved site-2 [IPR004036]", "Endonuclease III-like, iron-sulphur cluster loop motif [IPR003651]", "Enolase, conserved site [IPR020809]", "Enoyl-CoA hydratase/isomerase, conserved site [IPR018376]", "Ependymin, conserved site [IPR018224]", "Eukaryotic translation initiation factor 4E (eIF-4E), conserved site [IPR019770]", "F-actin capping protein, alpha subunit, conserved site [IPR017865]", "F-actin capping protein, beta subunit, conserved site [IPR019771]", "FERM conserved site [IPR019747]", "FLAP/GST2/LTC4S, conserved site [IPR018295]", "Fatty acid desaturase type 1, conserved site [IPR001522]", "Fibrillarin, conserved site [IPR020813]", "Formate-tetrahydrofolate ligase, FTHFS, conserved site [IPR020628]", "Fructose-bisphosphate aldolase class-I active site [IPR029768]", "Fumarate lyase, conserved site [IPR020557]", "GHMP kinase, ATP-binding, conserved site [IPR006203]", "GTP1/OBG, conserved site [IPR006074]", "Galactokinase, conserved site [IPR019741]", "Gamma-glutamyl phosphate reductase GPR, conserved site [IPR020593]", "Glucosamine-6-phosphate isomerase, conserved site [IPR018321]", "Glutamate 5-kinase, conserved site [IPR019797]", "Glycoside hydrolase family 27/36, conserved site [IPR000111]", "Glycoside hydrolase, family 2, conserved site [IPR023230]", "Glycoside hydrolase, family 29, conserved site [IPR018526]", "Glycoside hydrolase, family 35, conserved site [IPR019801]", "Glycosyl hydrolases family 31, conserved site [IPR030459]", "Glyoxalase I, conserved site [IPR018146]", "Guanylate kinase, conserved site [IPR020590]", "HIND motif [IPR045347]", "HMG box A DNA-binding domain, conserved site [IPR017967]", "HMG-I/HMG-Y, DNA-binding, conserved site [IPR000637]", "Haem oxygenase conserved site [IPR018207]", "Heat shock protein 70, conserved site [IPR018181]", "Heat shock protein Hsp90, conserved site [IPR019805]", "Heavy-metal-associated, conserved site [IPR017969]", "Helix-hairpin-helix motif [IPR000445]", "Helix-hairpin-helix motif, class 2 [IPR008918]", "Helix-turn-helix motif [IPR000047]", "Hexapeptide transferase, conserved site [IPR018357]", "Histidine triad, conserved site [IPR019808]", "Histone H2A conserved site [IPR032458]", "Histone H4, conserved site [IPR019809]", "Homeobox, conserved site [IPR017970]", "IMP dehydrogenase / GMP reductase, conserved site [IPR015875]", "Immunoglobulin/major histocompatibility complex, conserved site [IPR003006]", "Inositol monophosphatase, conserved site [IPR020550]", "Intermediate filament protein, conserved site [IPR018039]", "Isocitrate/isopropylmalate dehydrogenase, conserved site [IPR019818]", "Kinesin motor domain, conserved site [IPR019821]", "Lipocalin family conserved site [IPR022272]", "Lysosome-associated membrane glycoprotein, conserved site [IPR018134]", "Macrophage migration inhibitory factor, conserved site [IPR019829]", "Malic enzyme, conserved site [IPR015884]", "Mini-chromosome maintenance, conserved site [IPR018525]", "Mitogen-activated protein (MAP) kinase, conserved site [IPR003527]", "Mrp, conserved site [IPR000808]", "Myristoyl-CoA:protein N-myristoyltransferase, conserved site [IPR022678]", "NADH:ubiquinone oxidoreductase, 30kDa subunit, conserved site [IPR020396]", "NADH:ubiquinone oxidoreductase, 49kDa subunit, conserved site [IPR014029]", "NADH:ubiquinone oxidoreductase, 51kDa subunit, conserved site [IPR001949]", "NADH:ubiquinone oxidoreductase, 75kDa subunit, conserved site [IPR000283]", "NUDIX hydrolase, conserved site [IPR020084]", "Oxysterol-binding protein, conserved site [IPR018494]", "P-type trefoil, conserved site [IPR017957]", "Peptidase M22, conserved site [IPR017860]", "Peptidase M24B, X-Pro dipeptidase/aminopeptidase P, conserved site [IPR001131]", "Peptidase S26A, signal peptidase I, conserved site [IPR019758]", "Peptidyl-prolyl cis-trans isomerase, PpiC-type, conserved site [IPR023058]", "Phosphatidylethanolamine-binding, conserved site [IPR001858]", "Phosphatidylinositol 3/4-kinase, conserved site [IPR018936]", "Phosphoenolpyruvate carboxykinase, GTP-utilising, conserved site [IPR018091]", "Phosphofructokinase, conserved site [IPR015912]", "Phosphoglucose isomerase, conserved site [IPR018189]", "Phosphoglycerate kinase, conserved site [IPR015911]", "Phosphomannose isomerase, type I, conserved site [IPR018050]", "Phosphoribosyl pyrophosphate synthetase, conserved site [IPR000842]", "Phosphoribosylglycinamide synthetase, conserved site [IPR020559]", "Phosphorylase pyridoxal-phosphate attachment site [IPR035090]", "Polyamine biosynthesis domain, conserved site [IPR030373]", "Polyprenyl synthetase, conserved site [IPR033749]", "Procollagen-lysine 5-dioxygenase, conserved site [IPR001006]", "Profilin conserved site [IPR027310]", "Proliferating cell nuclear antigen, PCNA, conserved site [IPR022659]", "Proteasome beta-type subunit, conserved site [IPR016050]", "Protein phosphatase 2A regulatory subunit PR55, conserved site [IPR018067]", "Proteinase inhibitor I2, Kunitz, conserved site [IPR020901]", "Proteinase inhibitor I25, cystatin, conserved site [IPR018073]", "Pseudouridine synthase TruD, conserved site [IPR020119]", "Purine phosphorylase, family 2, conserved site [IPR018099]", "Quinone oxidoreductase/zeta-crystallin, conserved site [IPR002364]", "RIO kinase, conserved site [IPR018935]", "RNA 3'-terminal phosphate cyclase-like, conserved site [IPR020719]", "RNA polymerase, beta subunit, conserved site [IPR007121]", "Ras GTPase-activating protein, conserved site [IPR023152]", "Rel homology domain, conserved site [IPR030492]", "Retro-transposon transporting motif [IPR018892]", "Ribonuclease II/R, conserved site [IPR022966]", "Ribosomal RNA adenine methylase transferase, conserved site [IPR020596]", "Ribosomal S11, conserved site [IPR018102]", "Ribosomal S24e conserved site [IPR018098]", "Ribosomal protein L1, conserved site [IPR023673]", "Ribosomal protein L10e, conserved site [IPR018255]", "Ribosomal protein L11, conserved site [IPR020785]", "Ribosomal protein L13, conserved site [IPR023563]", "Ribosomal protein L13e, conserved site [IPR018256]", "Ribosomal protein L14P, conserved site [IPR019972]", "Ribosomal protein L15, conserved site [IPR001196]", "Ribosomal protein L15e, conserved site [IPR020925]", "Ribosomal protein L18e, conserved site [IPR021132]", "Ribosomal protein L19/L19e conserved site [IPR023638]", "Ribosomal protein L2, conserved site [IPR022671]", "Ribosomal protein L21e, conserved site [IPR018259]", "Ribosomal protein L22/L17, conserved site [IPR018260]", "Ribosomal protein L23/L25, conserved site [IPR001014]", "Ribosomal protein L24/L26, conserved site [IPR005825]", "Ribosomal protein L24e, conserved site [IPR023442]", "Ribosomal protein L27e, conserved site [IPR018262]", "Ribosomal protein L29, conserved site [IPR018254]", "Ribosomal protein L3, conserved site [IPR019926]", "Ribosomal protein L30, conserved site [IPR018038]", "Ribosomal protein L30e, conserved site [IPR022991]", "Ribosomal protein L31e, conserved site [IPR020052]", "Ribosomal protein L32e, conserved site [IPR018263]", "Ribosomal protein L34e, conserved site [IPR018065]", "Ribosomal protein L35Ae, conserved site [IPR018266]", "Ribosomal protein L37e, conserved site [IPR018267]", "Ribosomal protein L4/L1e, eukaryotic/archaeal, conserved site [IPR013000]", "Ribosomal protein L5, conserved site [IPR020929]", "Ribosomal protein L6, conserved site-2 [IPR002359]", "Ribosomal protein L7Ae conserved site [IPR004037]", "Ribosomal protein S10, conserved site [IPR018268]", "Ribosomal protein S13, conserved site [IPR018269]", "Ribosomal protein S17, conserved site [IPR019979]", "Ribosomal protein S17e, conserved site [IPR018273]", "Ribosomal protein S19e, conserved site [IPR018277]", "Ribosomal protein S2, conserved site [IPR018130]", "Ribosomal protein S21e, conserved site [IPR018279]", "Ribosomal protein S3, conserved site [IPR018280]", "Ribosomal protein S3Ae, conserved site [IPR018281]", "Ribosomal protein S4, conserved site [IPR018079]", "Ribosomal protein S4e, N-terminal, conserved site [IPR018199]", "Ribosomal protein S5, N-terminal, conserved site [IPR018192]", "Ribosomal protein S6e, conserved site [IPR018282]", "Ribosomal protein S7, conserved site [IPR020606]", "Ribosomal protein S8e, conserved site [IPR018283]", "Ribosomal protein S9, conserved site [IPR020574]", "Ribosome maturation protein SBDS, conserved site [IPR018023]", "RidA, conserved site [IPR019897]", "S-adenosyl-L-homocysteine hydrolase, conserved site [IPR020082]", "S-adenosylmethionine synthetase, conserved site [IPR022631]", "S100/Calbindin-D9k, conserved site [IPR001751]", "SAICAR synthetase, conserved site [IPR018236]", "SecY conserved site [IPR030659]", "Serpin, conserved site [IPR023795]", "Short-chain dehydrogenase/reductase, conserved site [IPR020904]", "Sodium:dicarboxylate symporter, conserved site [IPR018107]", "Squalene/phytoene synthase, conserved site [IPR019845]", "Stathmin, conserved site [IPR030514]", "Sterol reductase, conserved site [IPR018083]", "Succinyl-CoA synthetase, beta subunit, conserved site [IPR017866]", "Sulfatase, conserved site [IPR024607]", "Syntaxin/epimorphin, conserved site [IPR006012]", "TPP-binding enzyme, conserved site [IPR000399]", "Terpene synthase, conserved site [IPR002365]", "Tetrahydrofolate dehydrogenase/cyclohydrolase, conserved site [IPR020867]", "Tetraspanin, conserved site [IPR018503]", "Thiolase, conserved site [IPR020613]", "Thioredoxin, conserved site [IPR017937]", "Thiosulphate sulfurtransferase, conserved site [IPR001307]", "Thymidine kinase, conserved site [IPR020633]", "Thymidylate kinase, conserved site [IPR018095]", "Tr-type G domain, conserved site [IPR031157]", "Translation elongation factor EF1B, beta/delta chains, conserved site [IPR001326]", "Translation elongation factor Ts, conserved site [IPR018101]", "Translationally controlled tumour protein, conserved site [IPR018103]", "Tubulin, conserved site [IPR017975]", "Tyrosine-protein kinase, receptor class V, conserved site [IPR001426]", "UbiE/COQ5 methyltransferase, conserved site [IPR023576]", "Ubiquitin conserved site [IPR019954]", "Ubiquitin interacting motif [IPR003903]", "Ubiquitin specific protease, conserved site [IPR018200]", "Ubiquitin-activating enzyme E1, conserved site [IPR018074]", "Uncharacterised protein family UPF0029, Impact, conserved site [IPR020569]", "Vinculin, conserved site [IPR000633]", "WD40 repeat, conserved site [IPR019775]", "XPG conserved site [IPR019974]", "Zinc finger, PHD-type, conserved site [IPR019786]", "Zinc finger, RING-type, conserved site [IPR017907]"], "available_proteins": ["AAAS", "AAMP", "ABCB1", "ABCB7", "ABCD3", "ABCE1", "ABCF1", "ABCF2", "ABCF3", "ACAA2", "ACAD9", "ACADM", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACIN1", "ACLY", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN2", "ACTN4", "ACTR1A", "ACTR2", "ACTR3", "ADH5", "ADK", "ADSL", "AFG3L2", "AHCY", "AHCYL1", "AK1", "AK2", "AK3", "AKR1A1", "AKR1B1", "ALDH18A1", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ANXA1", "ANXA11", "ANXA2", "ANXA6", "ANXA7", "AP1M1", "AP1S2", "AP2M1", "AP2S1", "AP3M1", "APEX1", "APLP2", "APP", "ARIH2", "ARSA", "ATAD1", "ATP5C1", "ATP5O", "ATP7B", "BAG6", "BAZ1A", "BAZ1B", "BCS1L", "BOP1", "BPNT1", "BPTF", "BRD1", "BRD2", "BUD31", "CAD", "CALR", "CANX", "CAP1", "CAPZA1", "CAPZA2", "CAPZB", "CASK", "CBL", "CBR1", "CBX1", "CBX2", "CBX3", "CBX5", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CDC40", "CDX2", "CETN2", "CHAF1B", "CHD4", "CLGN", "CMPK1", "CNDP2", "COLEC12", "COPA", "COPZ1", "CORO1A", "CORO1C", "CORO7", "CPOX", "CRYZ", "CSTB", "CSTF1", "CTBP1", "CTBP2", "CTNNA1", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CYP51A1", "DCAF7", "DCPS", "DCXR", "DDT", "DDX10", "DDX17", "DDX18", "DDX20", "DDX23", "DDX24", "DDX27", "DDX3X", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX51", "DDX54", "DDX6", "DHCR7", "DHFR", "DHRS7", "DHX15", "DHX16", "DHX29", "DHX30", "DHX36", "DHX8", "DHX9", "DIDO1", "DIMT1", "DIS3", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC2", "DNAJC9", "DNM1L", "DNM2", "DNMT1", "DPY30", "DRG1", "DRG2", "DSC1", "DSC3", "DSG2", "DST", "DTYMK", "DYNLL1", "ECH1", "ECHS1", "ECI1", "ECI2", "EEF1A2", "EEF1B2", "EEF1D", "EEF2", "EIF3I", "EIF4A1", "EIF4A3", "EIF4E", "ENO1", "ENO2", "EPB41", "EPB41L2", "EPB41L5", "EPDR1", "EPHA7", "EPRS", "EPS15", "ERCC2", "ETFA", "ETFB", "EXO1", "EZR", "FBL", "FCGRT", "FDFT1", "FDPS", "FEN1", "FH", "FLNA", "FLNB", "FLNC", "FUCA1", "FUCA2", "GAA", "GALK1", "GALM", "GANAB", "GART", "GCDH", "GEMIN5", "GFM1", "GLA", "GLB1", "GLO1", "GMPPB", "GNPDA1", "GNS", "GPI", "GRHPR", "GRWD1", "GSPT1", "GTF3C2", "GUF1", "GUSB", "H2AFX", "H4C1*", "HADH", "HADHA", "HADHB", "HIBADH", "HLA-A", "HLA-B", "HLTF", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMOX1", "HMOX2", "HSD17B10", "HSD17B12", "HSD17B4", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA13", "HSPA14", "HSPA1B", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPD1", "HSPE1", "HSPH1", "HYOU1", "IARS", "IARS2", "IDH1", "IDH2", "IDH3A", "IDH3B", "ILVBL", "IMPACT", "IMPDH1", "IMPDH2", "INA", "IQGAP1", "IVD", "KDSR", "KIF11", "KIF18B", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF4A", "KIF5B", "KIF7", "KIFC1", "LAMP1", "LARS", "LARS2", "LBR", "LIG1", "LIG3", "LMNA", "LMNB1", "LMNB2", "LRWD1", "LSS", "MACF1", "MAPK1", "MARS", "MAT2A", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "ME1", "MGST2", "MID1", "MIF", "MKRN2", "MPI", "MPP6", "MPST", "MRPL3", "MRPS11", "MRPS2", "MRPS5", "MRPS9", "MSN", "MTAP", "MTHFD1", "MTHFD1L", "MTHFD2", "MTOR", "MVK", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFV1", "NEFL", "NEFM", "NES", "NLE1", "NMT1", "NNT", "NOP2", "NSD2", "NSF", "NTHL1", "NUBP2", "NUDT1", "NUDT12", "NUDT5", "NUP153", "NUP37", "NUP43", "NVL", "OSBP", "OSBPL8", "OSBPL9", "OSGEP", "P4HB", "PAFAH1B1", "PAICS", "PAK1IP1", "PBRM1", "PCK2", "PCNA", "PDIA3", "PDIA4", "PDIA6", "PEBP1", "PEPD", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGK1", "PGM1", "PGM2", "PGM3", "PHF14", "PHF8", "PHGDH", "PHIP", "PIK3C2A", "PIN1", "PLEC", "PLOD1", "PLOD2", "PLRG1", "PLS3", "PNP", "POLA1", "POLD1", "POLR1B", "POLR2B", "POLR2C", "PPIB", "PPID", "PPIF", "PPIG", "PPIH", "PPP2R2A", "PRKAR1A", "PRKAR2A", "PRKDC", "PRPF19", "PRPF4", "PRPS1", "PSMA4", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD4", "PUS7", "PWP1", "PWP2", "PYGB", "PYGL", "QARS", "QDPR", "RACK1", "RAE1", "RANBP2", "RARS", "RARS2", "RBBP4", "RBBP7", "RCL1", "RDH13", "RDX", "RELA", "RIDA", "RIOK2", "RNF2", "RNF40", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL15", "RPL17", "RPL18", "RPL19", "RPL21", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL37", "RPL4", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPS11", "RPS14", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS24", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS8", "RPS9", "RPSA", "RRP8", "RSF1", "RSL24D1", "S100A10", "S100A11", "SART1", "SBDS", "SCD", "SCP2", "SDHB", "SEC11A", "SEC61A1", "SERPINB6", "SERPINH1", "SLC1A5", "SLC25A42", "SLC27A2", "SLC27A4", "SLIT2", "SMARCA4", "SMU1", "SNRNP40", "SPATA5", "SPATA5L1", "SPTBN1", "SPTBN2", "SRCAP", "SRM", "STAM", "STMN1", "STOM", "STX18", "STX4", "STX5", "STX7", "SUCLA2", "SUCLG1", "SUCLG2", "SYNE2", "TBL3", "TCP1", "THOC6", "TK1", "TLN1", "TMX1", "TMX4", "TOP2A", "TOP2B", "TPT1", "TRAF2", "TRIM21", "TRIM25", "TRIM28", "TRIM33", "TRIP13", "TSFM", "TSPAN3", "TSPAN6", "TUBB", "TUBB2A", "TUBB2B", "TUBB4A", "TUBB4B", "TUBB6", "TUFM", "TXNDC12", "TXNDC5", "TXNL1", "UBA1", "UBA2", "UHRF1", "USP10", "USP11", "USP14", "USP24", "USP28", "USP34", "USP47", "USP48", "USP5", "USP7", "USP8", "USP9X", "UTP15", "UTP18", "UTRN", "VARS1", "VAT1", "VCL", "VCP", "VIM", "VPS4A", "VPS4B", "WARS", "WDHD1", "WDR1", "WDR12", "WDR18", "WDR3", "WDR36", "WDR41", "WDR5", "WDR61", "WDR77", "XPNPEP1", "YARS2", "YME1L1", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2"], "leading_proteins": ["APP", "CBX1", "CBX5", "DHCR7", "DSC3", "ECI2", "FCGRT", "FUCA2", "HADH", "HLA-B", "HMOX2", "IDH2", "MRPS5", "MRPS9", "PFN2", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB6", "PSMB7", "STX18", "STX7", "TSPAN6"]} \ No newline at end of file diff --git a/interpro_domain/advanced/idx2term.json b/interpro_domain/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..77ea1800f5e8b49fc487ea07eb190d776febe0bf --- /dev/null +++ b/interpro_domain/advanced/idx2term.json @@ -0,0 +1 @@ +{"0": "Immunoglobulin-like domain [IPR007110]"} \ No newline at end of file diff --git a/interpro_domain/advanced/plot_0.png b/interpro_domain/advanced/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..eba3b9fce43d226f55e3f258697ca16084a8612d --- /dev/null +++ b/interpro_domain/advanced/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:4f09f69a1d7d16f02f2096a40e9db7ec5f6aa44821be320e42eddc65250c7ba8 +size 184162 diff --git a/interpro_domain/basic/idx2term.json b/interpro_domain/basic/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..f88e15e748a241ecb4747e9d3c4accb4fc1a3795 --- /dev/null +++ b/interpro_domain/basic/idx2term.json @@ -0,0 +1 @@ +{"0": "Immunoglobulin-like domain [IPR007110]", "1": "K Homology domain, type 1 [IPR004088]", "2": "K Homology domain [IPR004087]", "3": "RNA recognition motif domain [IPR000504]", "4": "EF-hand domain [IPR002048]"} \ No newline at end of file diff --git a/interpro_domain/basic/plot_0.png b/interpro_domain/basic/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..5ec521f3950289d31e427627d3dce21ed9092f66 --- /dev/null +++ b/interpro_domain/basic/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:9ac67fe208e2ce4e58ba65b92cdd77c704007d7eb3d6aec42433af072ba66e76 +size 135217 diff --git a/interpro_domain/basic/plot_1.png b/interpro_domain/basic/plot_1.png new file mode 100644 index 0000000000000000000000000000000000000000..e6cb0950d5c1f08e562003e9ed9edbdc783e4ade --- /dev/null +++ b/interpro_domain/basic/plot_1.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:958bbdc16ea8d2a78426ce321d8572aa2e106b5ecff0f376d1dfabc19034f272 +size 137401 diff --git a/interpro_domain/basic/plot_2.png b/interpro_domain/basic/plot_2.png new file mode 100644 index 0000000000000000000000000000000000000000..44107040e973fc6ff78bf64c959617657c16f1ca --- /dev/null +++ b/interpro_domain/basic/plot_2.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:0984685119de054e6b6bd39809ae18508207adaf2e31c0c4ad103aa01538dbae +size 141351 diff --git a/interpro_domain/basic/plot_3.png b/interpro_domain/basic/plot_3.png new file mode 100644 index 0000000000000000000000000000000000000000..5025cb62b5ff585f698b79e64a23c8b8641b494c --- /dev/null +++ b/interpro_domain/basic/plot_3.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:0d9d2d749299b29340da3cfb2807d488d718d01f7a14a52831d5f1affc439721 +size 145477 diff --git a/interpro_domain/basic/plot_4.png b/interpro_domain/basic/plot_4.png new file mode 100644 index 0000000000000000000000000000000000000000..219e8b12b9faaac2c6ea955f5426fafe558303ec --- /dev/null +++ b/interpro_domain/basic/plot_4.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:628ce43a1d71ccdac524ca4557dca4a05d892b6ca52cfaa071dd63fa21f3414f +size 136711 diff --git a/interpro_domain/consensus.joblib b/interpro_domain/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..40fc96f366bf94b557b8cc025594cd1e331ead97 --- /dev/null +++ b/interpro_domain/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:10c03b48de6525da8eebe70d208772d0253a5cfcbeba532effbd249750f2727c +size 114035 diff --git a/interpro_domain/df_merge.tsv b/interpro_domain/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..c5dbfabee9f9f108430bd4d296f3ef763e83b6d2 --- /dev/null +++ b/interpro_domain/df_merge.tsv @@ -0,0 +1,4 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Immunoglobulin-like domain [IPR007110] 6 8 2.160187820201851 0.0307581326578179 4.480582524271845 12.427184466019416 0.4075261998509777 0.4433674298264088 2.6479725987944898 3.173316973839475 1.1756568118942026 0.3233613924696422 0.4905798305311465 1.0 0.2961867551178612 0.1392614494667218 0.3074046968153315 +Cytochrome b5-like heme/steroid binding domain [IPR001199] 3 5 1.9992599546240293 0.0455802345866265 2.813106796116505 6.104368932038835 1.6405397264547834 0.1100883340733615 1.2852875686886795 0.8042848477475721 1.100790504333474 0.1612592696854457 0.0125560894119173 0.0561990347849709 0.1094892401774078 0.000142755965642 0.0001560226497295 +Band 7 domain [IPR001107] 3 8 1.9887346361279348 0.046730500813708 3.825242718446602 7.354368932038835 0.2848798017769268 0.3662852929750465 1.8717479731706237 0.7075565364256523 1.25010454777189 0.3076860385713043 0.1233512907074988 0.0424464003246627 0.0832836732680532 0.0188064524051028 0.0005644670723367 diff --git a/interpro_domain/metrics.json b/interpro_domain/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..8afbe99d9102f7a0943ae62b5fdd50e438812fdf --- /dev/null +++ b/interpro_domain/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2644, + "annotations_size": 2312, + "title": "Average number of proteins per term", + "value": 2.0666089965397925 +} \ No newline at end of file diff --git a/interpro_domain/paths.json b/interpro_domain/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..383d411a38dcb52892d2cd4814af3b68eb47829b --- /dev/null +++ b/interpro_domain/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/interpro_domain/fragment/C197/C197_val_log2fc"} \ No newline at end of file diff --git a/interpro_domain/result.tsv b/interpro_domain/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..6dac67c5736b6c43b05436fba22685fcb0c07336 --- /dev/null +++ b/interpro_domain/result.tsv @@ -0,0 +1,166 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Immunoglobulin C1-set [IPR003597] 0.9344696969696976 2.211935000685298 0.0269711564275496 1.0 0.5982949461849505 4 P55899,P01889,P10321 3 +MHC class I-like antigen recognition-like [IPR011161] 0.9344696969696976 2.211935000685298 0.0269711564275496 1.0 0.5982949461849505 4 P55899,P01889,P10321 3 +Immunoglobulin-like domain [IPR007110] 0.8037005606618264 2.160187820201851 0.0307581326578179 1.0 0.5982949461849505 8 P01889,P35613,P04439,P78310,P10321,P55899 6 +Cytochrome b5-like heme/steroid binding domain [IPR001199] 0.8431482253799534 1.9992599546240295 0.0455802345866265 1.0 0.5982949461849505 5 O15173,Q9UMX5,O43169 3 +Band 7 domain [IPR001107] 0.7657695270150455 1.9887346361279348 0.046730500813708 1.0 0.5982949461849505 8 O75955,P27105,Q14254 3 +Aminopeptidase N-like , N-terminal domain [IPR045357] 0.8310580844152108 1.9493511842688092 0.0512534999439111 1.0 0.5982949461849505 5 P09960,Q9UIQ6,P55786 3 +Peptidase M1, membrane alanine aminopeptidase [IPR014782] 0.8310580844152108 1.9493511842688092 0.0512534999439111 1.0 0.5982949461849505 5 P09960,Q9UIQ6,P55786 3 +Dynamin, N-terminal [IPR045063] 0.8113959079505944 1.9104530777926176 0.0560749023756035 1.0 0.5982949461849505 6 Q9H4M9,Q9H223,O00429 3 +Dynamin-type guanine nucleotide-binding (G) domain [IPR030381] 0.8113959079505944 1.9104530777926176 0.0560749023756035 1.0 0.5982949461849505 6 Q9H4M9,Q9H223,O00429 3 +MHC class I alpha chain, alpha1 alpha2 domains [IPR001039] 0.9341158652025732 1.8881764148678863 0.0590022709750188 1.0 0.5982949461849505 3 P01889,P10321 2 +MHC class I, alpha chain, C-terminal [IPR010579] 0.9341158652025732 1.8881764148678863 0.0590022709750188 1.0 0.5982949461849505 3 P01889,P10321 2 +TRAM/LAG1/CLN8 homology domain [IPR006634] 0.9038243089738752 1.7676347695050647 0.0771219814406947 1.0 0.5982949461849505 3 Q15629,Q96G23 2 +P-type ATPase, haloacid dehalogenase domain [IPR044492] 0.7790829859795405 1.7320628259576831 0.0832623770267044 1.0 0.5982949461849505 5 P05023,P35670,Q9HD20,P16615 4 +ERAP1-like C-terminal domain [IPR024571] 0.8924649753881135 1.722217686459327 0.0850300921202895 1.0 0.5982949461849505 3 P55786,Q9UIQ6 2 +Fxr1, tudor domain [IPR041560] 0.88034835289663 1.6736605745703517 0.0941973263089877 1.0 0.5982949461849505 3 Q06787,P51116 2 +Fragile X-related 1 protein, C-terminal core [IPR022034] 0.88034835289663 1.6736605745703517 0.0941973263089877 1.0 0.5982949461849505 3 Q06787,P51116 2 +Synaptic functional regulator FMRP, KH0 domain [IPR040472] 0.88034835289663 1.6736605745703517 0.0941973263089877 1.0 0.5982949461849505 3 Q06787,P51116 2 +Agenet-like domain [IPR008395] 0.88034835289663 1.6736605745703517 0.0941973263089877 1.0 0.5982949461849505 3 Q06787,P51116 2 +START domain [IPR002913] 0.8755941979381814 1.6545795318796603 0.0980098182357762 1.0 0.5982949461849505 3 Q9NQZ5 1 +Pancreatic trypsin inhibitor Kunitz domain [IPR002223] 0.9746404239212711 1.6333779899592 0.1023895232075535 1.0 0.5982949461849505 2 P05067 1 +Amyloidogenic glycoprotein, copper-binding [IPR011178] 0.9746404239212711 1.6333779899592 0.1023895232075535 1.0 0.5982949461849505 2 P05067 1 +Amyloidogenic glycoprotein, extracellular [IPR008154] 0.9746404239212711 1.6333779899592 0.1023895232075535 1.0 0.5982949461849505 2 P05067 1 +Beta-amyloid precursor protein C-terminal [IPR019543] 0.9746404239212711 1.6333779899592 0.1023895232075535 1.0 0.5982949461849505 2 P05067 1 +Amyloidogenic glycoprotein, heparin-binding [IPR015849] 0.9746404239212711 1.6333779899592 0.1023895232075535 1.0 0.5982949461849505 2 P05067 1 +Amyloidogenic glycoprotein, E2 domain [IPR024329] 0.9746404239212711 1.6333779899592 0.1023895232075535 1.0 0.5982949461849505 2 P05067 1 +Zinc finger, CHHC-type [IPR012996] 0.8686103748580098 1.6265226985986567 0.1038385086903437 1.0 0.5982949461849505 3 P31943,P52597 2 +Alpha-L-fucosidase, C-terminal [IPR031919] 0.9682059046177132 1.60703621727939 0.108046423516257 1.0 0.6023421129028675 2 Q9BTY2 1 +Peptidase C1A, papain C-terminal [IPR000668] 0.9678274034822096 1.6054864449286408 0.1083867939046254 1.0 0.6023421129028675 2 P07858 1 +MD-2-related lipid-recognition domain [IPR003172] 0.9647993943981829 1.5930874182888344 0.111140581450198 1.0 0.6089029012153029 2 P61916 1 +RNA recognition motif domain, eukaryote [IPR003954] 0.5881423170224857 1.5805428766113494 0.1139825958296023 1.0 0.6164913794160536 12 Q9UHX1,Q14011,O95628,Q01085 4 +PA domain [IPR003137] 0.9610143830431483 1.5775868484436604 0.1146605556892148 1.0 0.6171649997878655 2 Q8TCT8 1 +Glycoside hydrolase family 2, catalytic domain [IPR006103] 0.9598788796366382 1.5729363714925944 0.1157335521839577 1.0 0.6171649997878655 2 O00462 1 +Glycoside hydrolase family 20, catalytic domain [IPR015883] 0.9572293716881142 1.562084850936088 0.1182680011726575 1.0 0.6171649997878655 2 P06865 1 +Beta-hexosaminidase, eukaryotic type, N-terminal [IPR029019] 0.9572293716881142 1.562084850936088 0.1182680011726575 1.0 0.6171649997878655 2 P06865 1 +MRH domain [IPR044865] 0.8479833939340822 1.5434959646980693 0.1227104858284633 1.0 0.6205891266344203 3 P11717 1 +Isopropylmalate dehydrogenase-like domain [IPR024084] 0.7701371634676966 1.5411513637949172 0.123279951382424 1.0 0.6205891266344203 4 P48735 1 +Target SNARE coiled-coil homology domain [IPR000727] 0.7293681958821134 1.5205083181201673 0.1283832697613975 1.0 0.622699175890074 5 O15400,Q9UNK0 2 +CBS domain [IPR000644] 0.7145108970650725 1.4966722028811237 0.1344785725505868 1.0 0.622699175890074 6 P51798,Q6P4Q7,P51790 3 +Phospholipase D/Transphosphatidylase [IPR001736] 0.9375473126419368 1.481475993437278 0.1384797774611024 1.0 0.622699175890074 2 Q8IV08 1 +BTB/POZ domain [IPR000210] 0.8235516849678292 1.4449412578841871 0.1484743862174127 1.0 0.622699175890074 3 Q9NXV2,Q08380 2 +Marvel domain [IPR008253] 0.922785768357304 1.4210622126746937 0.1552986740860884 1.0 0.6294953490441882 2 Q16625 1 +Transcription factor CBF/NF-Y/archaeal histone domain [IPR003958] 0.7355038235095461 1.3960314980923407 0.1627050102061287 1.0 0.6395228965444812 4 Q9NR33,Q01658 2 +Immunoglobulin subtype 2 [IPR003598] 0.7258354780772105 1.3554165443123911 0.175284881466101 1.0 0.6401953721888786 4 P78310,P35613 2 +Immunoglobulin subtype [IPR003599] 0.7258354780772105 1.3554165443123911 0.175284881466101 1.0 0.6401953721888786 4 P78310,P35613 2 +GNAT domain [IPR000182] 0.7206818115920142 1.333757417134934 0.1822833707455284 1.0 0.6401953721888786 4 Q86UY6 1 +SET domain [IPR001214] 0.7947747065505514 1.328786544623126 0.1839184025874338 1.0 0.6401953721888786 3 Q03164,Q9H7B4 2 +K Homology domain, type 1 [IPR004088] 0.4981188804121305 1.2954764245837749 0.1951559289806443 1.0 0.6529674497876263 22 Q92945,Q07666,Q96I24,Q96AE4,P51116,P51114,Q06787 7 +Zinc finger, RanBP2-type [IPR001876] 0.6178031385446371 1.290308109169367 0.1969437024696767 1.0 0.6570144466148349 8 P35637,Q01844 2 +N-acetylgalactosaminyltransferase [IPR045885] 0.782658084059069 1.279933250392116 0.2005686124058021 1.0 0.6615044677349708 3 Q10472,Q10471 2 +Cation-transporting P-type ATPase, N-terminal [IPR004014] 0.778492995077626 1.2631556986540955 0.2065332302856997 1.0 0.6668245861351374 3 P05023,P16615 2 +Cation-transporting P-type ATPase, C-terminal [IPR006068] 0.778492995077626 1.2631556986540955 0.2065332302856997 1.0 0.6668245861351374 3 P05023,P16615 2 +Flavoprotein pyridine nucleotide cytochrome reductase [IPR001709] 0.7771433997231343 1.2577214681048234 0.2084925054638313 1.0 0.6668245861351374 3 P16435 1 +Oxidoreductase FAD/NAD(P)-binding [IPR001433] 0.7771433997231343 1.2577214681048234 0.2084925054638313 1.0 0.6668245861351374 3 P16435 1 +FAD-binding domain, ferredoxin reductase-type [IPR017927] 0.7771433997231343 1.2577214681048234 0.2084925054638313 1.0 0.6668245861351374 3 P16435 1 +Fragile X-related 1 protein, C-terminal region 1 [IPR032172] 0.8800151400454199 1.2466963853061617 0.2125088447303125 1.0 0.6695137752103392 2 P51116 1 +CARG-binding factor, N-terminal [IPR012956] 0.8781226343679036 1.239018875910164 0.2153385077699752 1.0 0.6722488610715363 2 Q99729 1 +EH domain-containing protein, N-terminal [IPR031692] 0.8762301286903866 1.2313456423313394 0.2181936179797508 1.0 0.6762247248916673 2 Q9H223 1 +Domain of unknown function DUF5600 [IPR040990] 0.8762301286903866 1.2313456423313394 0.2181936179797508 1.0 0.6762247248916673 2 Q9H223 1 +Peptidase M16, C-terminal [IPR007863] 0.6295116526161347 1.2287336160102211 0.2191716981260587 1.0 0.6765353352035351 7 Q5JRX3,Q10713 2 +Peptidase M16, N-terminal [IPR011765] 0.6295116526161347 1.2287336160102211 0.2191716981260587 1.0 0.6765353352035351 7 Q5JRX3,Q10713 2 +Heterogeneous nuclear ribonucleoprotein Q acidic domain [IPR041337] 0.8743376230128685 1.223676827138079 0.2210741646842797 1.0 0.6787828270253051 2 O60506 1 +FKBP-type peptidyl-prolyl cis-trans isomerase domain [IPR001179] 0.5756018692741155 1.2053310670582535 0.2280755209276304 1.0 0.6871414341396783 9 P62942,Q9Y680,Q9NWM8,Q96AY3 4 +Prolyl 4-hydroxylase alpha subunit, Fe(2+) 2OG dioxygenase domain [IPR044862] 0.8663890991672962 1.1915193486791418 0.2334497654755094 1.0 0.6919690484350998 2 Q32P28 1 +K Homology domain [IPR004087] 0.4804086074272598 1.1770108204068617 0.2391911874784231 1.0 0.6977171693039659 22 Q92945,Q07666,Q96I24,Q96AE4,P51116,P51114,Q06787 7 +Major facilitator superfamily domain [IPR020846] 0.7493373722075025 1.1460792371618254 0.2517623677300822 1.0 0.7039858405153155 3 Q9H2V7,P53985 2 +Chromo shadow domain [IPR008251] 0.7383566830745956 1.1022211527052397 0.2703655380757939 1.0 0.7115983071132126 3 P45973,P83916 2 +Chromo domain subgroup [IPR017984] 0.7383566830745956 1.1022211527052397 0.2703655380757939 1.0 0.7115983071132126 3 P45973,P83916 2 +CYRIA/CYRIB, Rac1 binding domain [IPR009828] 0.8440575321725965 1.101700748682816 0.2705917913733797 1.0 0.7115983071132126 2 Q9NUQ9 1 +Heat shock protein DnaJ, cysteine-rich domain [IPR001305] 0.7364192222869907 1.0945001923560076 0.2737356630580589 1.0 0.7115983071132126 3 Q96EY1 1 +PTBP1, RNA recognition motif 2-like [IPR021790] 0.6628787878787937 1.0911715330377922 0.2751974114404318 1.0 0.7115983071132126 4 Q8WVV9,Q9UKA9,P14866 3 +Ricin B, lectin domain [IPR000772] 0.6549816550160632 1.0582100768556923 0.2899596781999363 1.0 0.7225593016562613 4 Q10472,Q10471 2 +Zinc finger C2H2 AKAP95-type [IPR034736] 0.7270845438820368 1.0573840927213007 0.2903363283904268 1.0 0.7225593016562613 3 Q5BKZ1 1 +Tim44-like domain [IPR007379] 0.8323239969719902 1.054889526970879 0.2914758526542318 1.0 0.7244009150517877 2 O43615 1 +Guanylate kinase-like domain [IPR008144] 0.7238024831375997 1.0443696621774132 0.2963143941351092 1.0 0.725082990034074 3 Q9NZW5 1 +Guanylate kinase/L-type calcium channel beta subunit [IPR008145] 0.7238024831375997 1.0443696621774132 0.2963143941351092 1.0 0.725082990034074 3 Q9NZW5 1 +Potassium channel tetramerisation-type BTB domain [IPR003131] 0.8232399697199084 1.0188657332601123 0.3082667137087695 1.0 0.7385623234141713 2 Q9NXV2 1 +Far upstream element-binding protein, C-terminal [IPR015096] 0.8126419379258122 0.9771095773183252 0.3285149068139761 1.0 0.7578014084126786 2 Q92945 1 +3-hydroxyacyl-CoA dehydrogenase, NAD binding [IPR006176] 0.8118849356548048 0.9741390919397898 0.3299874818228634 1.0 0.7578014084126786 2 Q16836 1 +3-hydroxyacyl-CoA dehydrogenase, C-terminal [IPR006108] 0.8118849356548048 0.9741390919397898 0.3299874818228634 1.0 0.7578014084126786 2 Q16836 1 +Glycosyltransferase 2-like [IPR001173] 0.6316713797549103 0.961455828033624 0.3363230251913669 1.0 0.7632489572941026 4 Q10472,Q10471 2 +Exportin-2, central domain [IPR013713] 0.7015238331465441 0.9566115124417898 0.3387633758784831 1.0 0.7671115818129804 3 O95373 1 +Glycerol-3-phosphate acyltransferase-like, C-terminal domain [IPR045520] 0.8035579106737301 0.9415782221865548 0.3464086238279764 1.0 0.7744208468514083 2 Q9HCL2 1 +GPAT/DHAPAT, acyltransferase domain [IPR041728] 0.8035579106737301 0.9415782221865548 0.3464086238279764 1.0 0.7744208468514083 2 Q9HCL2 1 +Post-SET domain [IPR003616] 0.7944738834216487 0.906312769637629 0.3647703284919377 1.0 0.7849371362953258 2 Q03164 1 +Reticulon [IPR003388] 0.7929598788796335 0.9004628709366863 0.3678739757452396 1.0 0.7887959731964711 2 O95197 1 +Amino acid permease/ SLC12A domain [IPR004841] 0.7831188493565462 0.8626450464359732 0.3883326551573787 1.0 0.7970964393274065 2 P55011 1 +SLC12A transporter, C-terminal [IPR018491] 0.7831188493565462 0.8626450464359732 0.3883326551573787 1.0 0.7970964393274065 2 P55011 1 +Serine-threonine/tyrosine-protein kinase, catalytic domain [IPR001245] 0.6741106120351807 0.8504098828058042 0.3950972434941238 1.0 0.8005826704280581 3 Q15375 1 +RBM3/CIRBP, RNA recognition motif [IPR034278] 0.7713853141559402 0.8180592364254196 0.4133233636655531 1.0 0.8093541389951123 2 Q14011 1 +RNA recognition motif domain [IPR000504] 0.3639943811704467 0.7158275195577659 0.4740978575684262 1.0 0.8457671656621925 100 Q8IXT5,P31942,Q96PK6,P52597,Q01844,P22626,P35637,P31943,O95628,Q13151,Q99729,Q9UHX1,Q92804,O14979,Q14103,Q01085,P51991,Q14011,O43390,P38159,Q9UKA9,P55795,Q8IY67,O60506,Q9BWF3 25 +Acyl-CoA-binding protein, ACBP [IPR000582] 0.7339137017411017 0.6800896718731139 0.4964476836801856 1.0 0.8538947206285513 2 O75521 1 +Legume-like lectin [IPR005052] 0.7259651778955301 0.6518401128286335 0.5145043216670095 1.0 0.8637684792114707 2 P49257 1 +NOPS [IPR012975] 0.6149185914426284 0.6313822993835742 0.5277905867739463 1.0 0.8641492530884108 3 P23246,Q15233 2 +Peptidase M3A/M3B catalytic domain [IPR001567] 0.6145431023771605 0.6300523484630068 0.5286603349790446 1.0 0.8641492530884108 3 Q9BYT8 1 +Tudor domain [IPR002999] 0.5149167752618382 0.6257230028769644 0.5314966426867302 1.0 0.8641492530884108 6 Q14739 1 +Survival motor neuron [IPR010304] 0.7142316426949243 0.6108926153903019 0.5412706739518238 1.0 0.8739558691748792 2 Q16637 1 +HDGF-related, PWWP domain [IPR035496] 0.6084816357440384 0.6087083426126049 0.542717776274311 1.0 0.8748194466118253 3 P51858,Q7Z4V5 2 +Major sperm protein (MSP) domain [IPR000535] 0.6009087466868532 0.5823865879934066 0.5603063134944588 1.0 0.8887818428510963 3 Q8NHP6,Q9P0L0 2 +Oxoglutarate/iron-dependent dioxygenase [IPR005123] 0.5347365726304029 0.5773516396518049 0.5637019360482478 1.0 0.8887818428510963 4 Q32P28 1 +Prolyl 4-hydroxylase, alpha subunit [IPR006620] 0.5347365726304029 0.5773516396518049 0.5637019360482478 1.0 0.8887818428510963 4 Q32P28 1 +CTP synthase GATase domain [IPR033828] 0.7009841029523046 0.5658329637822342 0.5715073356616662 1.0 0.8921843079336748 2 P17812 1 +CTP synthase, N-terminal [IPR017456] 0.7009841029523046 0.5658329637822342 0.5715073356616662 1.0 0.8921843079336748 2 P17812 1 +TGS [IPR004095] 0.4987083532321295 0.5584235444967534 0.5765551990525675 1.0 0.8964328313446779 6 Q9NTK5 1 +R3H domain [IPR001374] 0.5861416130253636 0.5322458035548973 0.5945557632144713 1.0 0.9130183026087516 3 O95453,Q9H6S0 2 +OCRE domain [IPR041591] 0.6896290688872021 0.5282856745210791 0.5973010729632573 1.0 0.9157560216784156 2 P52756 1 +LEM-like domain [IPR013146] 0.6888720666161954 0.5258198213208154 0.5990134012888673 1.0 0.917164889920438 2 P42167 1 +SKP1 component, POZ domain [IPR016073] 0.6828160484481407 0.5062673640725357 0.612668970434346 1.0 0.920720926747568 2 P63208 1 +Serine hydroxymethyltransferase-like domain [IPR039429] 0.6797880393641134 0.4966097397257876 0.6194642834950328 1.0 0.9238371433518816 2 P34896 1 +ELMO domain [IPR006816] 0.6688115064345141 0.4622905062001506 0.6438730068882719 1.0 0.9385057441616126 2 Q8IZ81 1 +NLE [IPR012972] 0.6582134746404185 0.4302290896118792 0.667029003385041 1.0 0.9545546847348 2 Q9GZL7 1 +ATPase family AAA domain-containing protein 3, N-terminal [IPR021911] 0.6551854655563911 0.4212712259258311 0.6735570390574908 1.0 0.9575628230287592 2 Q9NVI7 1 +Zinc finger, CCHC-type [IPR001878] 0.4484568444761162 0.4133980230786602 0.6793150228002898 1.0 0.960009983321681 7 Q9NUD5 1 +SAM-dependent methyltransferase RsmB/NOP2-type [IPR001678] 0.5347018581451038 0.3722410803092374 0.7097133625067416 1.0 0.9735050154641008 3 Q96P11 1 +LEM domain [IPR003887] 0.4504976213742251 0.3683910390597127 0.7125816781821339 1.0 0.9754226405903456 6 Q86XL3 1 +G-protein, beta subunit [IPR001632] 0.6294473883421587 0.3490031021897213 0.7270869806208693 1.0 0.9806610765493814 2 Q9NVX2 1 +Cadherin-like [IPR002126] 0.5231767518201947 0.3400572383522252 0.7338134236140064 1.0 0.980827925789202 3 Q14574 1 +SCP2 sterol-binding domain [IPR003033] 0.5164710336993535 0.3220276907058437 0.7474317168345703 1.0 0.980827925789202 3 P51659,Q6YN16 2 +Exocyst complex component EXOC2/Sec5, N-terminal domain [IPR039481] 0.6139288417865186 0.3089960399311613 0.7573245392001511 1.0 0.980827925789202 2 Q9UID3 1 +Chromo domain [IPR023780] 0.4339897600668437 0.306671579329375 0.7590933644565205 1.0 0.980827925789202 5 P45973,P83916 2 +DNA2/NAM7 helicase-like, C-terminal [IPR041679] 0.4515847427479421 0.2988995163619052 0.7650167161347798 1.0 0.980827925789202 4 Q9HCE1,O60306 2 +Lens epithelium-derived growth factor, integrase-binding domain [IPR021567] 0.6082513247539674 0.2950687930911773 0.7679413284341223 1.0 0.980827925789202 2 Q7Z4V5 1 +Histone-binding protein RBBP4, N-terminal [IPR022052] 0.4884513441878082 0.2525947139483202 0.8005814152465338 1.0 0.980827925789202 3 Q9BQ67,Q09028 2 +Serine-threonine protein phosphatase, N-terminal [IPR031675] 0.5836487509462454 0.2392993717230179 0.8108734525504717 1.0 0.980827925789202 2 P62140 1 +Brix domain [IPR007109] 0.4299242424242533 0.2392267056457077 0.8109297956575696 1.0 0.980827925789202 4 Q96G21,Q9H7B2,Q9NQ55 3 +PABP, RNA recognition motif 2 [IPR045305] 0.5772142316426904 0.225973434355888 0.8212220822492642 1.0 0.980827925789202 2 Q13310 1 +Pseudouridine synthase II, N-terminal [IPR002501] 0.5749432248296671 0.2213970210299046 0.8247833117569252 1.0 0.980827925789202 2 Q8WWH5 1 +XPC-binding domain [IPR015360] 0.5730507191521507 0.2176340860467473 0.8277142241755022 1.0 0.980827925789202 2 P54725 1 +RAD23A/RAD23B, UBA1 domain [IPR041811] 0.5730507191521507 0.2176340860467473 0.8277142241755022 1.0 0.980827925789202 2 P54725 1 +Beta-Casp domain [IPR022712] 0.467625899280562 0.2075341448901166 0.8355927293228169 1.0 0.980827925789202 3 Q9UKF6,Q5TA45 2 +Aminotransferase, class I/classII [IPR004839] 0.3986738567926406 0.198364662412934 0.8427597633609691 1.0 0.980827925789202 5 O15269 1 +Pyrroline-5-carboxylate reductase, dimerisation domain [IPR029036] 0.5423921271763729 0.1631306649933326 0.870415556010476 1.0 0.980827925789202 2 P32322 1 +Pyrroline-5-carboxylate reductase, catalytic, N-terminal [IPR028939] 0.5423921271763729 0.1631306649933326 0.870415556010476 1.0 0.980827925789202 2 P32322 1 +Methyltransferase type 11 [IPR013216] 0.5355791067373129 0.1526644960490447 0.8786628605461735 1.0 0.980827925789202 2 Q6FI81 1 +Small-subunit processome, Utp12 [IPR007148] 0.4255963650132428 0.1344755969597232 0.8930265066084544 1.0 0.980827925789202 3 Q15269,Q15061 2 +Nucleoporin, Nup133/Nup155-like, C-terminal [IPR007187] 0.5189250567751614 0.129545650878903 0.8969259050713227 1.0 0.980827925789202 2 Q8WUM0 1 +EF-hand domain [IPR002048] 0.3353590823656791 0.1258267332117309 0.899869079907436 1.0 0.980827925789202 44 P80303,Q14257,O43852,Q9Y680,Q02818 5 +Proteasome activator PA28, C-terminal domain [IPR003186] 0.4184021204089265 0.1243687497997235 0.9010233152619408 1.0 0.980827925789202 3 P61289,Q9UL46 2 +Proteasome activator PA28, N-terminal domain [IPR003185] 0.4184021204089265 0.1243687497997235 0.9010233152619408 1.0 0.980827925789202 3 P61289,Q9UL46 2 +ABC transporter type 1, transmembrane domain [IPR011527] 0.4117905131299706 0.1156828356573919 0.9079039100715928 1.0 0.982643731745196 3 P08183 1 +2Fe-2S ferredoxin-type iron-sulfur binding domain [IPR001041] 0.5045420136260311 0.1123108824854929 0.9105769134218508 1.0 0.984683734252254 2 P28331 1 +Zn-dependent metallo-hydrolase, RNA specificity domain [IPR011108] 0.497350492051466 0.1046042677942002 0.9166898280779918 1.0 0.9888955176192435 2 Q5TA45 1 +Ancestral coatomer element 1, Sec16/Sec31 [IPR024298] 0.4784254352762951 0.0870594714919429 0.9306242400860488 1.0 0.9888955176192435 2 O15027 1 +Class II aldolase/adducin N-terminal [IPR001303] 0.4757759273277774 0.0849040700003037 0.9323376560814712 1.0 0.9888955176192435 2 Q9UEY8 1 +Ran binding domain [IPR000156] 0.3503787878787998 0.0794288572128987 0.9366915164084846 1.0 0.9888955176192435 4 Q9UKX7,Q9H6Z4,P43487 3 +GINS subunit, domain A [IPR021151] 0.4534443603330697 0.0694146671909446 0.9446595543500832 1.0 0.9888955176192435 2 Q9BRX5 1 +Ariadne domain [IPR045840] 0.450416351249046 0.0676585275774773 0.946057463820825 1.0 0.9888955176192435 2 O95376 1 +TRIAD supradomain [IPR044066] 0.450416351249046 0.0676585275774773 0.946057463820825 1.0 0.9888955176192435 2 O95376 1 +IBR domain [IPR002867] 0.450416351249046 0.0676585275774773 0.946057463820825 1.0 0.9888955176192435 2 O95376 1 +Exonuclease, RNase T/DNA polymerase III [IPR013520] 0.442846328538974 0.0635965835095783 0.949291452201506 1.0 0.9888955176192435 2 Q9GZR2 1 +Coatomer subunit gamma, C-terminal [IPR032154] 0.4390613171839398 0.0617340849574712 0.9507745958548852 1.0 0.9888955176192435 2 Q9Y678 1 +Coatomer, gamma subunit, appendage, Ig-like subdomain [IPR013040] 0.4390613171839398 0.0617340849574712 0.9507745958548852 1.0 0.9888955176192435 2 Q9Y678 1 +Transcription elongation factor, TFIIS/CRSP70, N-terminal, sub-type [IPR003617] 0.3498674744415014 0.0598073028089577 0.952309109190422 1.0 0.9888955176192435 3 Q14241,P23193 2 +Transcription factor IIS, N-terminal [IPR017923] 0.3498674744415014 0.0598073028089577 0.952309109190422 1.0 0.9888955176192435 3 Q14241,P23193 2 +Septin-type guanine nucleotide-binding (G) domain [IPR030379] 0.3430518742900456 0.056093834305687 0.9552670557180438 1.0 0.9888955176192435 3 Q16181,Q15019 2 +SGS domain [IPR007699] 0.4118092354276992 0.0512439292341059 0.959131147339266 1.0 0.9888955176192435 2 Q9HB71 1 +Thiamine pyrophosphate enzyme, N-terminal TPP-binding domain [IPR012001] 0.393262679788035 0.0465372113519926 0.9628820758319612 1.0 0.9888955176192435 2 A1L0T0 1 +Thiamine pyrophosphate enzyme, C-terminal TPP-binding [IPR011766] 0.393262679788035 0.0465372113519926 0.9628820758319612 1.0 0.9888955176192435 2 A1L0T0 1 +Thiamine pyrophosphate enzyme, central domain [IPR012000] 0.393262679788035 0.0465372113519926 0.9628820758319612 1.0 0.9888955176192435 2 A1L0T0 1 +CRAL-TRIO lipid binding domain [IPR001251] 0.3875851627554804 0.0454100574078385 0.9637804646062528 1.0 0.9888955176192435 2 Q8NHP6 1 +Ribosomal protein S5, C-terminal [IPR005324] 0.369417108251315 0.0426025975062169 0.9660183248613908 1.0 0.9888955176192435 2 P82675 1 +Ribosomal protein S5, N-terminal [IPR013810] 0.369417108251315 0.0426025975062169 0.9660183248613908 1.0 0.9888955176192435 2 P82675 1 +Transcription elongation factor S-II, central domain [IPR003618] 0.3444360333080926 0.0402613236083672 0.96788478805125 1.0 0.9888955176192435 2 P23193 1 +Hexokinase, C-terminal [IPR022673] 0.3050719152157387 0.0386802528548032 0.9691453175646784 1.0 0.9888955176192435 2 P52789 1 +Hexokinase, N-terminal [IPR022672] 0.3050719152157387 0.0386802528548032 0.9691453175646784 1.0 0.9888955176192435 2 P52789 1 +DNA2/NAM7 helicase, helicase domain [IPR041677] 0.2494945508766823 0.0340735362328422 0.9728185112542732 1.0 0.9908177964845284 3 O60306 1 diff --git a/interpro_domain/selections.json b/interpro_domain/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..83c37f016f18f88efb93d87b3d98aeee40b0cc3e --- /dev/null +++ b/interpro_domain/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["1-acyl-sn-glycerol-3-phosphate acyltransferase [IPR004552]", "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, SH3 domain [IPR035724]", "116kDa U5 small nuclear ribonucleoprotein component, C-terminal [IPR035655]", "116kDa U5 small nuclear ribonucleoprotein component, N-terminal [IPR031950]", "14-3-3 domain [IPR023410]", "18S rRNA (guanine(1575)-N(7))-methyltransferase Bud23, C-terminal [IPR022238]", "2-oxoacid dehydrogenase acyltransferase, catalytic domain [IPR001078]", "2-oxoglutarate dehydrogenase E1 component, N-terminal domain [IPR032106]", "26S proteasome non-ATPase regulatory subunit RPN1, C-terminal [IPR041433]", "26S proteasome regulatory subunit RPN2, C-terminal [IPR040623]", "26S proteasome regulatory subunit RPN5, C-terminal domain [IPR040896]", "26S proteasome regulatory subunit Rpn6, N-terminal [IPR040773]", "26S proteasome regulatory subunit Rpn7, N-terminal [IPR045135]", "26S proteasome regulatory subunit, C-terminal [IPR013586]", "2Fe-2S ferredoxin-type iron-sulfur binding domain [IPR001041]", "3'-5' exonuclease domain [IPR002562]", "3-beta hydroxysteroid dehydrogenase/isomerase [IPR002225]", "3-hydroxyacyl-CoA dehydrogenase, C-terminal [IPR006108]", "3-hydroxyacyl-CoA dehydrogenase, NAD binding [IPR006176]", "3-hydroxyisobutyrate dehydrogenase, NAD-binding domain [IPR029154]", "3-oxo-5-alpha-steroid 4-dehydrogenase, C-terminal [IPR001104]", "4'-phosphopantetheinyl transferase domain [IPR008278]", "40S ribosomal protein S11, N-terminal [IPR032440]", "40S ribosomal protein S4, C-terminal domain [IPR032277]", "40S ribosomal protein SA, C-terminal domain [IPR032281]", "4Fe-4S ferredoxin-type, iron-sulphur binding domain [IPR017896]", "6-phosphogluconate dehydrogenase, C-terminal [IPR006114]", "6-phosphogluconate dehydrogenase, NADP-binding [IPR006115]", "6-phosphogluconolactonase, DevB-type [IPR005900]", "60S ribosomal protein L10P, insertion domain [IPR040637]", "60S ribosomal protein L4, C-terminal domain [IPR025755]", "6S proteasome subunit Rpn6, C-terminal helix domain [IPR040780]", "A kinase-anchoring protein AKAP5 and AKAP12, calmodulin (CaM)-binding motif [IPR001573]", "AAA ATPase, AAA+ lid domain [IPR041569]", "AAA+ ATPase domain [IPR003593]", "AARP2CN [IPR012948]", "AATF leucine zipper-containing domain [IPR025160]", "ABC transporter type 1, transmembrane domain [IPR011527]", "ABC transporter-like, ATP-binding domain [IPR003439]", "ABC-transporter extension domain [IPR032781]", "ABC1 atypical kinase-like domain [IPR004147]", "ADAR1, first double-stranded RNA binding domain [IPR044456]", "ADAR1, third double-stranded RNA binding domain [IPR044457]", "ADCK3-like domain [IPR034646]", "ADNP, zinc finger domain [IPR045762]", "AGC-kinase, C-terminal [IPR000961]", "AIMP2, lysyl-tRNA synthetase binding domain [IPR031889]", "AIMP2, thioredoxin-like domain [IPR041503]", "ALIX V-shaped domain [IPR025304]", "AMP-binding enzyme, C-terminal domain [IPR025110]", "AMP-dependent synthetase/ligase [IPR000873]", "AP complex, mu/sigma subunit [IPR022775]", "AP-2 complex subunit mu, N-terminal [IPR043532]", "AP-3 complex subunit beta 1, serine-rich domain [IPR029394]", "AP-3 complex subunit beta, C-terminal domain [IPR029390]", "AP-3 complex subunit delta domain, metazoa [IPR010474]", "AP180 N-terminal homology (ANTH) domain [IPR011417]", "APC10/DOC domain [IPR004939]", "ARHGEF1-like, PH domain [IPR041020]", "ARHGEF2, PH domain [IPR037806]", "ARID DNA-binding domain [IPR001606]", "ARMET, C-terminal [IPR019345]", "ARMET, N-terminal [IPR045332]", "ATP synthase, F1 complex, alpha subunit nucleotide-binding domain [IPR033732]", "ATP synthase, alpha subunit, C-terminal [IPR000793]", "ATP-citrate lyase/succinyl-CoA ligase [IPR005811]", "ATP-citrate synthase, citrate-binding domain [IPR032263]", "ATP-cone domain [IPR005144]", "ATP-dependent DNA helicase RecQ, zinc-binding domain [IPR032284]", "ATP-dependent RNA helicase Ski2, C-terminal [IPR012961]", "ATP-dependent RNA helicase eIF4A, DEAD-box helicase domain [IPR044728]", "ATP-dependent helicase, C-terminal [IPR006555]", "ATP-grasp fold [IPR011761]", "ATP-grasp fold, succinyl-CoA synthetase-type [IPR013650]", "ATP-sulfurylase PUA-like domain [IPR025980]", "ATP:guanido phosphotransferase, N-terminal [IPR022413]", "ATP:guanido phosphotransferase, catalytic domain [IPR022414]", "ATPase family AAA domain-containing protein 3, N-terminal [IPR021911]", "ATPase, AAA-type, core [IPR003959]", "ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain [IPR004100]", "ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domain [IPR000194]", "ATPase, V1 complex, subunit H, C-terminal [IPR011987]", "ATPase, dynein-related, AAA domain [IPR011704]", "ATPsynthase alpha/beta subunit, N-terminal extension [IPR031686]", "AWS domain [IPR006560]", "Abl Interactor 1, SH3 domain [IPR035725]", "Abl-interactor, homeo-domain homologous domain [IPR012849]", "Acetyl-CoA carboxylase [IPR034733]", "Acetyl-CoA carboxylase, central domain [IPR013537]", "Acetyl-coA carboxylase zinc finger domain [IPR041010]", "Acetyl-coenzyme A carboxyltransferase, C-terminal [IPR011763]", "Acetyl-coenzyme A carboxyltransferase, N-terminal [IPR011762]", "Acid ceramidase, N-terminal [IPR029130]", "Acinus, RNA recognition motif [IPR034257]", "Aconitase A/isopropylmalate dehydratase small subunit, swivel domain [IPR000573]", "Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain [IPR001030]", "Actin-depolymerising factor homology domain [IPR002108]", "Activating signal cointegrator 1 complex subunit 2, CUE domain [IPR041800]", "Activator of Hsp90 ATPase, N-terminal [IPR015310]", "Acyl transferase [IPR014043]", "Acyl-CoA dehydrogenase/oxidase C-terminal [IPR009075]", "Acyl-CoA dehydrogenase/oxidase, N-terminal [IPR013786]", "Acyl-CoA oxidase, C-terminal [IPR002655]", "Acyl-CoA oxidase/dehydrogenase, central domain [IPR006091]", "Acyl-CoA-binding protein, ACBP [IPR000582]", "Acyl-coenzyme A oxidase, N-terminal [IPR029320]", "Acylamino-acid-releasing enzyme, N-terminal domain [IPR045550]", "Acylglycerol kinase, C-terminal [IPR045579]", "Acyltransferase, C-terminal domain [IPR032098]", "Adaptor protein Cbl, EF hand-like [IPR014741]", "Adaptor protein Cbl, N-terminal helical [IPR003153]", "Adaptor protein Cbl, PTB domain [IPR024159]", "Adaptor protein Cbl, SH2-like domain [IPR014742]", "Adaptor protein ClpS, core [IPR003769]", "Adenosine deaminase/editase [IPR002466]", "Adenylate cyclase-associated CAP, C-terminal [IPR013912]", "Adenylate cyclase-associated CAP, N-terminal [IPR013992]", "Adenylate kinase, active site lid domain [IPR007862]", "Adenylosuccinate lyase C-terminal [IPR019468]", "Afadin, cargo binding domain [IPR037977]", "Agenet-like domain [IPR008395]", "Alanine dehydrogenase/pyridine nucleotide transhydrogenase, N-terminal [IPR007886]", "Alanine dehydrogenase/pyridine nucleotide transhydrogenase, NAD(H)-binding domain [IPR007698]", "Alanyl-tRNA synthetase, class IIc, N-terminal [IPR018164]", "Alanyl-tRNA synthetase, class IIc, core domain [IPR018165]", "Alcohol dehydrogenase, N-terminal [IPR013154]", "Alcohol dehydrogenase-like, C-terminal [IPR013149]", "Aldehyde dehydrogenase domain [IPR015590]", "Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant [IPR000866]", "Alpha Spectrin, SH3 domain [IPR035825]", "Alpha crystallin/Hsp20 domain [IPR002068]", "Alpha galactosidase A, C-terminal beta-sandwich domain [IPR035373]", "Alpha-D-phosphohexomutase, C-terminal [IPR005843]", "Alpha-D-phosphohexomutase, alpha/beta/alpha domain I [IPR005844]", "Alpha-D-phosphohexomutase, alpha/beta/alpha domain II [IPR005845]", "Alpha-D-phosphohexomutase, alpha/beta/alpha domain III [IPR005846]", "Alpha-L-fucosidase, C-terminal [IPR031919]", "Alpha-N-acetylglucosaminidase, C-terminal [IPR024732]", "Alpha-N-acetylglucosaminidase, N-terminal [IPR024240]", "Alpha-N-acetylglucosaminidase, tim-barrel domain [IPR024733]", "Alpha-glycerophosphate oxidase, C-terminal [IPR031656]", "Alpha-ketoglutarate-dependent dioxygenase AlkB-like [IPR027450]", "Alpha-ketoglutarate-dependent dioxygenase FTO, C-terminal [IPR024366]", "Alpha-ketoglutarate-dependent dioxygenase FTO, catalytic domain [IPR024367]", "Alpha/beta hydrolase fold-1 [IPR000073]", "Amidohydrolase-related [IPR006680]", "Amidophosphoribosyltransferase, N-terminal [IPR035584]", "Amine oxidase [IPR002937]", "Amino acid permease, N-terminal [IPR013612]", "Amino acid permease/ SLC12A domain [IPR004841]", "Amino acid transporter, transmembrane domain [IPR013057]", "Aminoacyl-tRNA synthetase, class II (D/K/N) [IPR004364]", "Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) [IPR002314]", "Aminoacyl-tRNA synthetase, class II [IPR006195]", "Aminoacyl-tRNA synthetase, class Ia [IPR002300]", "Aminomethyltransferase, folate-binding domain [IPR006222]", "Aminopeptidase N-like , N-terminal domain [IPR045357]", "Aminopeptidase P [IPR033740]", "Aminopeptidase P, N-terminal [IPR007865]", "Aminotransferase class V domain [IPR000192]", "Aminotransferase, class I/classII [IPR004839]", "Amyloidogenic glycoprotein, E2 domain [IPR024329]", "Amyloidogenic glycoprotein, amyloid-beta peptide [IPR013803]", "Amyloidogenic glycoprotein, copper-binding [IPR011178]", "Amyloidogenic glycoprotein, extracellular [IPR008154]", "Amyloidogenic glycoprotein, heparin-binding [IPR015849]", "Anaphase-promoting complex subunit 1, C-terminal [IPR041221]", "Anaphase-promoting complex subunit 4, WD40 domain [IPR024977]", "Anaphase-promoting complex subunit 5 domain [IPR026000]", "Ancestral coatomer element 1, Sec16/Sec31 [IPR024298]", "Angiomotin, C-terminal [IPR024646]", "Anillin homology domain [IPR012966]", "Anillin, N-terminal domain [IPR031970]", "Anillin, PH domain [IPR037840]", "Anion-transporting ATPase-like domain [IPR025723]", "Ankyrin repeat and LEM domain-containing protein 2, LEM domain [IPR035006]", "Anticodon-binding [IPR004154]", "Anticodon-binding domain [IPR019181]", "Antifreeze-like/N-acetylneuraminic acid synthase C-terminal [IPR006190]", "ApaG domain [IPR007474]", "Apoptosis-antagonizing transcription factor, C-terminal [IPR012617]", "Arf GTPase activating protein [IPR001164]", "Arfaptin homology (AH) domain [IPR010504]", "Arginyl tRNA synthetase N-terminal domain [IPR005148]", "Arginyl-tRNA synthetase, catalytic core domain [IPR035684]", "Ariadne domain [IPR045840]", "Armadillo repeat-containing domain [IPR006911]", "Aromatic amino acid beta-eliminating lyase/threonine aldolase [IPR001597]", "Asparagine synthase [IPR001962]", "Asparagine synthase, N-terminal domain [IPR033738]", "Aspartate/glutamate/uridylate kinase [IPR001048]", "Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding domain [IPR006131]", "Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding [IPR006132]", "Aspartic peptidase, DDI1-type [IPR019103]", "Aspartyl beta-hydroxylase/Triadin domain [IPR007943]", "Aspartyl/asparaginy/proline hydroxylase [IPR007803]", "Ataxin 2, SM domain [IPR025852]", "Ataxin-10 domain [IPR019156]", "Ataxin-2, C-terminal [IPR009818]", "Aurora kinase A [IPR030611]", "Aurora-A binding [IPR015128]", "B-block binding subunit of TFIIIC [IPR007309]", "B-box, C-terminal [IPR003649]", "B-box-type zinc finger [IPR000315]", "B3/B4 tRNA-binding domain [IPR005146]", "B30.2/SPRY domain [IPR001870]", "BAG domain [IPR003103]", "BAP29/BAP31, transmembrane domain [IPR040463]", "BAR domain [IPR004148]", "BAT2, N-terminal [IPR009738]", "BCAS3 domain [IPR022175]", "BCS1, N-terminal [IPR014851]", "BEACH domain [IPR000409]", "BOP1, N-terminal domain [IPR012953]", "BP28, C-terminal domain [IPR012954]", "BR140-related, PWWD domain [IPR035502]", "BRAP2, RNA recognition motif [IPR034932]", "BRCA1-associated 2 [IPR011422]", "BRCT domain [IPR001357]", "BRICHOS domain [IPR007084]", "BRK domain [IPR006576]", "BRO1 domain [IPR004328]", "BRPF2, PHD domain [IPR042009]", "BRPF2, ePHD domain [IPR042004]", "BSD domain [IPR005607]", "BTB/Kelch-associated [IPR011705]", "BTB/POZ domain [IPR000210]", "BURAN domain [IPR045354]", "BZW1/2, W2 domain [IPR043510]", "Bacterial Ig-like, group 2 [IPR003343]", "Bacterial surface antigen (D15) [IPR000184]", "Band 3 cytoplasmic domain [IPR013769]", "Band 4.1 domain [IPR019749]", "Band 4.1, C-terminal [IPR008379]", "Band 7 domain [IPR001107]", "Band 7, C-terminal extension [IPR032435]", "Bap31/Bap29 cytoplasmic coiled-coil domain [IPR041672]", "Beta-Casp domain [IPR022712]", "Beta-adaptin appendage, C-terminal subdomain [IPR015151]", "Beta-amyloid precursor protein C-terminal [IPR019543]", "Beta-catenin-like protein 1, N-terminal [IPR013180]", "Beta-galactosidase jelly roll domain [IPR025300]", "Beta-hexosaminidase, eukaryotic type, N-terminal [IPR029019]", "Beta-ketoacyl synthase, C-terminal [IPR014031]", "Beta-ketoacyl synthase, N-terminal [IPR014030]", "Beta-mannosidase, Ig-fold domain [IPR041625]", "Bicarbonate transporter, C-terminal [IPR011531]", "Bifunctional delta 1-pyrroline-5-carboxylate synthetase, glutamate-5-kinase domain [IPR041744]", "Biliverdin reductase, catalytic [IPR015249]", "Biotin carboxylase, C-terminal [IPR005482]", "Biotin carboxylase-like, N-terminal domain [IPR005481]", "Biotin carboxylation domain [IPR011764]", "Biotin protein ligase, C-terminal [IPR003142]", "Biotin-protein ligase, N-terminal [IPR019197]", "Biotin/lipoyl attachment [IPR000089]", "Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL), catalytic domain [IPR004143]", "Bms1/Tsr1-type G domain [IPR030387]", "Borealin, N-terminal [IPR018851]", "Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase, N-terminal [IPR018955]", "Brdt, bromodomain, repeat I [IPR043508]", "Brdt, bromodomain, repeat II [IPR043509]", "Brix domain [IPR007109]", "Bromo adjacent homology (BAH) domain [IPR001025]", "Bromodomain [IPR001487]", "Bromodomain adjacent to zinc finger domain protein 1A, bromodomain [IPR037325]", "Brr2, N-terminal helicase PWI domain [IPR041094]", "Butyrophylin-like, SPRY domain [IPR003879]", "C-CAP/cofactor C-like domain [IPR017901]", "C-terminal associated domain of TOPRIM [IPR031660]", "C-type lectin-like [IPR001304]", "C2 DOCK-type domain [IPR027007]", "C2 domain [IPR000008]", "C2 phosphatidylinositol 3-kinase-type domain [IPR002420]", "C4-type zinc-finger of DNA polymerase delta [IPR025687]", "CAAX prenyl protease 1, N-terminal [IPR032456]", "CALCOCO1/2, zinc finger UBZ1-type [IPR041641]", "CAP Gly-rich domain [IPR000938]", "CAPN2, penta-EF hand, calcium binding motif [IPR042736]", "CARG-binding factor, N-terminal [IPR012956]", "CARP motif [IPR006599]", "CASK, SH3 domain [IPR035473]", "CBS domain [IPR000644]", "CCAAT-binding factor [IPR005612]", "CCR4-NOT transcription complex subunit 1, CAF1-binding domain [IPR032191]", "CCR4-NOT transcription complex subunit 1, HEAT repeat [IPR032194]", "CCR4-NOT transcription complex subunit 1, TTP binding domain [IPR032193]", "CCR4-NOT transcription complex subunit 1, domain 4 [IPR024557]", "CCR4-Not complex component, Not N-terminal domain [IPR007207]", "CCR4-Not complex component, Not1, C-terminal [IPR007196]", "CD2-associated protein, first SH3 domain [IPR035775]", "CD2-associated protein, second SH3 domain [IPR035776]", "CD2-associated protein, third SH3 domain [IPR035777]", "CD209-like, C-type lectin-like domain [IPR033989]", "CDC48, N-terminal subdomain [IPR003338]", "CDC48, domain 2 [IPR004201]", "CENP-T/Histone H4, histone fold [IPR035425]", "CFA20 domain [IPR007714]", "CHD subfamily II, SANT-like domain [IPR009462]", "CHD, C-terminal 2 [IPR012957]", "CHD, N-terminal [IPR012958]", "CHIP, N-terminal tetratricopeptide repeat domain [IPR041312]", "CHIP/LubX , U box domain [IPR045202]", "CHORD domain [IPR007051]", "CID domain [IPR006569]", "CIDE-N domain [IPR003508]", "CLASP N-terminal domain [IPR024395]", "CLIP1, zinc knuckle [IPR032108]", "CLU central domain [IPR033646]", "CLU domain [IPR025697]", "CNNM, transmembrane domain [IPR002550]", "CNOT4, RNA recognition motif [IPR034261]", "COMM domain [IPR017920]", "COP9 signalosome complex subunit 4, helix turn helix domain [IPR041406]", "COP9 signalosome complex subunit 7, helix I [IPR041481]", "COQ9 [IPR013718]", "COS domain [IPR017903]", "CP2 transcription factor [IPR007604]", "CPL domain [IPR012959]", "CPSF7, RNA recognition motif [IPR034773]", "CRA domain [IPR013144]", "CRAL-TRIO lipid binding domain [IPR001251]", "CRIB domain [IPR000095]", "CRK, C-terminal SH3 domain [IPR035458]", "CRK, N-terminal SH3 domain [IPR035457]", "CS domain [IPR007052]", "CSK-like, SH2 domain [IPR035027]", "CSN8/PSMD8/EIF3K [IPR033464]", "CTLH, C-terminal LisH motif [IPR006595]", "CTLH/CRA C-terminal to LisH motif domain [IPR024964]", "CTP synthase GATase domain [IPR033828]", "CTP synthase, N-terminal [IPR017456]", "CUB domain [IPR000859]", "CYRIA/CYRIB, Rac1 binding domain [IPR009828]", "Cadherin prodomain [IPR014868]", "Cadherin, cytoplasmic domain [IPR000233]", "Cadherin-like [IPR002126]", "Calcineurin-like phosphoesterase domain, ApaH type [IPR004843]", "Calcineurin-like phosphoesterase domain, lpxH-type [IPR024654]", "Calcium binding and coiled-coil domain-like [IPR012852]", "Calcium uniporter protein, C-terminal [IPR006769]", "Calcium/calmodulin-dependent protein kinase II, association-domain [IPR013543]", "Calcyclin-binding Protein, CS domain [IPR037893]", "Calpain subdomain III [IPR033883]", "Calponin homology domain [IPR001715]", "Caprin-1 dimerization domain [IPR041637]", "Carbamoyl-phosphate synthase large subunit, CPSase domain [IPR005483]", "Carbamoyl-phosphate synthase small subunit, GATase1 domain [IPR035686]", "Carbamoyl-phosphate synthase small subunit, N-terminal domain [IPR002474]", "Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain [IPR005479]", "Carbamoyl-phosphate synthetase, large subunit oligomerisation domain [IPR005480]", "Carbohydrate kinase PfkB [IPR011611]", "Carboxylase, conserved domain [IPR003379]", "Carboxypeptidase D, carboxypeptidase-like domain 2 [IPR034224]", "Carboxypeptidase D, carboxypeptidase-like domain 3 [IPR033848]", "Casein kinase substrate, phosphoprotein PP28 [IPR019380]", "Caspase recruitment domain [IPR031964]", "Cathepsin C [IPR039412]", "Cathepsin C exclusion [IPR014882]", "Cation-transporting P-type ATPase, C-terminal [IPR006068]", "Cation-transporting P-type ATPase, N-terminal [IPR004014]", "Caudal-like activation domain [IPR006820]", "Cdc23 [IPR007192]", "Cdc37, C-terminal [IPR013873]", "Cdc37, Hsp90 binding [IPR013874]", "Cdc37, N-terminal domain [IPR013855]", "Cell division control protein 73, C-terminal [IPR031336]", "Cellular tumor antigen p53, transactivation domain 2 [IPR040926]", "Centromere protein Cenp-F, N-terminal [IPR018463]", "Centromere protein Cenp-F, leucine-rich repeat-containing domain [IPR019513]", "Chaperone DnaJ, C-terminal [IPR002939]", "Chitinase II [IPR011583]", "Choline/carnitine acyltransferase domain [IPR039551]", "Choloylglycine hydrolase/NAAA C-terminal [IPR029132]", "Chromatin assembly factor 1 subunit B, C-terminal domain [IPR029129]", "Chromatin assembly factor 1 subunit p150, C-terminal [IPR029105]", "Chromatin assembly factor 1 subunit p150, N-terminal [IPR029091]", "Chromo domain [IPR023780]", "Chromo domain subgroup [IPR017984]", "Chromo shadow domain [IPR008251]", "Chromo/chromo shadow domain [IPR000953]", "Chromosome passenger complex (CPC) protein INCENP N-terminal [IPR022006]", "Chromosome segregation protein Spc25, C-terminal [IPR013255]", "Circularly permuted (CP)-type guanine nucleotide-binding (G) domain [IPR030378]", "Class I myosin tail homology domain [IPR010926]", "Class I myosin, motor domain [IPR036072]", "Class II PurE [IPR033626]", "Class II aldolase/adducin N-terminal [IPR001303]", "Class VI myosin, motor domain [IPR036114]", "Clathrin adaptor, alpha-adaptin, appendage, C-terminal subdomain [IPR003164]", "Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain [IPR008152]", "Clathrin, heavy chain, linker, core motif [IPR015348]", "Clathrin/coatomer adaptor, adaptin-like, N-terminal [IPR002553]", "Cleavage stimulation factor subunit 1, dimerisation domain [IPR032028]", "Cleavage stimulation factor subunit 2, hinge domain [IPR025742]", "Cleavage/polyadenylation specificity factor, A subunit, C-terminal [IPR004871]", "Cleavage/polyadenylation specificity factor, A subunit, N-terminal [IPR018846]", "Clp ATPase, C-terminal [IPR019489]", "Clustered mitochondria protein, N-terminal [IPR028275]", "Cns1/TTC4, wheel domain [IPR044059]", "CoA-binding [IPR003781]", "Coagulation factor 5/8 C-terminal domain [IPR000421]", "Coatomer beta subunit, C-terminal [IPR011710]", "Coatomer beta subunit, appendage platform domain [IPR029446]", "Coatomer subunit gamma, C-terminal [IPR032154]", "Coatomer, WD associated region [IPR006692]", "Coatomer, alpha subunit, C-terminal [IPR010714]", "Coatomer, gamma subunit, appendage, Ig-like subdomain [IPR013040]", "Cobalamin (vitamin B12)-binding domain [IPR006158]", "Cobalamin (vitamin B12)-binding module, cap domain [IPR003759]", "Coilin, N-terminal domain [IPR031722]", "Cold shock domain [IPR011129]", "Cold-shock (CSD) domain [IPR019844]", "Cold-shock protein, DNA-binding [IPR002059]", "Condensin complex subunit 1, C-terminal [IPR032682]", "Condensin complex subunit 1, N-terminal [IPR024324]", "Cop9 signalosome subunit 5 C-terminal domain [IPR040961]", "Copine, C-terminal [IPR010734]", "Copine, C2B domain [IPR037768]", "Core histone macro-H2A, macro domain [IPR035796]", "Cortactin, SH3 domain [IPR035716]", "Creatinase, N-terminal [IPR000587]", "Cro/C1-type helix-turn-helix domain [IPR001387]", "Cullin homology domain [IPR016158]", "Cullin protein, neddylation domain [IPR019559]", "Cullin, N-terminal [IPR001373]", "Cupin-like domain 8 [IPR041667]", "Cwf19-like protein, C-terminal domain-2 [IPR006767]", "Cwf19-like, C-terminal domain-1 [IPR006768]", "Cyclic nucleotide-binding domain [IPR000595]", "Cyclin, C-terminal domain [IPR004367]", "Cyclin, N-terminal [IPR006671]", "Cyclin-like [IPR013763]", "Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain [IPR002130]", "Cystatin domain [IPR000010]", "Cysteine-rich flanking region, C-terminal [IPR000483]", "Cystine knot, C-terminal [IPR006207]", "Cytochrome C oxidase subunit II, transmembrane domain [IPR011759]", "Cytochrome b5-like heme/steroid binding domain [IPR001199]", "Cytochrome c oxidase subunit 2, C-terminal [IPR034210]", "Cytochrome c oxidase subunit II-like C-terminal [IPR002429]", "Cytochrome c oxidase, subunit II [IPR014222]", "Cytoplasmic activation/proliferation-associated protein-1 C term [IPR022070]", "Cytoskeleton-associated protein 2, C-terminal [IPR029197]", "D-3-phosphoglycerate dehydrogenase, ASB domain [IPR045626]", "D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain [IPR006140]", "D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain [IPR006139]", "DALR anticodon binding [IPR008909]", "DAZ-associated protein 1, RNA recognition motif 1 [IPR034134]", "DAZ-associated protein 1, RNA recognition motif 2 [IPR034131]", "DBC1/CARP1 catalytically inactive NUDIX hydrolase domain [IPR025954]", "DBINO domain [IPR020838]", "DBP10, C-terminal [IPR012541]", "DDE superfamily endonuclease domain [IPR004875]", "DDHD domain [IPR004177]", "DDT domain [IPR018501]", "DDX18/Has1, DEAD-box helicase domain [IPR044773]", "DDX41, DEAD-box helicase domain [IPR044113]", "DDX47/Rrp3, DEAD-box helicase domain [IPR044765]", "DDX52/Rok1, DEAD-box helicase domain [IPR044764]", "DEAD box protein 17, ATP-binding domain [IPR046330]", "DEAD/DEAH box helicase domain [IPR011545]", "DEAD2 [IPR010614]", "DEK, C-terminal [IPR014876]", "DEUBAD domain [IPR044867]", "DExH-box ATP-dependent RNA helicase, R3H domain [IPR034083]", "DFDF domain [IPR025762]", "DHHA1 domain [IPR003156]", "DHX15, DEXH-box helicase domain [IPR044756]", "DHX8/ Prp22, DEXH-box helicase domain [IPR044762]", "DHX9, DEXH-box helicase domain [IPR044447]", "DHX9, first double-stranded RNA binding domain [IPR044445]", "DHX9, second double-stranded RNA binding domain [IPR044446]", "DJ-1/PfpI [IPR002818]", "DM10 domain [IPR006602]", "DMAP1-binding domain [IPR010506]", "DML1/Misato, tubulin domain [IPR029209]", "DNA (cytosine-5)-methyltransferase 1, replication foci domain [IPR022702]", "DNA damage inducible protein 1 ubiquitin-like domain [IPR033882]", "DNA fragmentation factor 45kDa, middle domain [IPR015121]", "DNA ligase 3, BRCT domain [IPR031916]", "DNA ligase, ATP-dependent, C-terminal [IPR012309]", "DNA ligase, ATP-dependent, N-terminal [IPR012308]", "DNA ligase, ATP-dependent, central [IPR012310]", "DNA mismatch repair protein MutS, C-terminal [IPR000432]", "DNA mismatch repair protein MutS, clamp [IPR007861]", "DNA mismatch repair protein MutS, connector domain [IPR007860]", "DNA mismatch repair protein MutS, core [IPR007696]", "DNA mismatch repair protein MutS-like, N-terminal [IPR007695]", "DNA polymerase alpha catalytic subunit, N-terminal domain [IPR024647]", "DNA polymerase alpha catalytic subunit, catalytic domain [IPR045846]", "DNA polymerase alpha, subunit B, N-terminal [IPR013627]", "DNA polymerase alpha/delta/epsilon, subunit B [IPR007185]", "DNA polymerase delta subunit 2, C-terminal domain [IPR041863]", "DNA polymerase delta subunit, OB-fold domain [IPR040663]", "DNA polymerase epsilon, catalytic subunit A, C-terminal [IPR013697]", "DNA repair Nbs1, C-terminal [IPR013908]", "DNA replication complex GINS protein SLD5, C-terminal [IPR031633]", "DNA replication factor Dna2, N-terminal [IPR014808]", "DNA replication factor RFC1, C-terminal [IPR013725]", "DNA topoisomerase 2, TOPRIM domain [IPR034157]", "DNA topoisomerase I, DNA binding, eukaryotic-type [IPR008336]", "DNA topoisomerase I, catalytic core, eukaryotic-type [IPR013500]", "DNA topoisomerase I, eukaryotic-type [IPR013499]", "DNA topoisomerase, type IIA, domain A [IPR002205]", "DNA topoisomerase, type IIA, subunit B, domain 2 [IPR013506]", "DNA-dependent protein kinase catalytic subunit, CC3 [IPR012582]", "DNA-dependent protein kinase catalytic subunit, CC5 [IPR045581]", "DNA-dependent protein kinase catalytic subunit, catalytic domain [IPR037706]", "DNA-directed DNA polymerase, family B, exonuclease domain [IPR006133]", "DNA-directed DNA polymerase, family B, multifunctional domain [IPR006134]", "DNA-directed RNA polymerase I subunit RPA2, domain 4 [IPR009674]", "DNA-directed RNA polymerase III subunit RPC1, C-terminal [IPR035698]", "DNA-directed RNA polymerase III subunit RPC1, N-terminal [IPR035697]", "DNA-directed RNA polymerase, N-terminal [IPR029262]", "DNA-directed RNA polymerase, RpoA/D/Rpb3-type [IPR011263]", "DNA-directed RNA polymerase, insert domain [IPR011262]", "DNA-directed RNA polymerase, subunit 2, hybrid-binding domain [IPR007120]", "DNA/RNA non-specific endonuclease [IPR001604]", "DNA2/NAM7 helicase, helicase domain [IPR041677]", "DNA2/NAM7 helicase-like, C-terminal [IPR041679]", "DOCKER domain [IPR027357]", "DSBA-like thioredoxin domain [IPR001853]", "DTHCT [IPR012542]", "DWNN domain [IPR014891]", "DZF domain [IPR006561]", "Damage-control phosphatase ARMT1-like, metal-binding domain [IPR002791]", "Dbl homology (DH) domain [IPR000219]", "Death domain [IPR000488]", "Dedicator of cytokinesis C, C2 domain [IPR037808]", "Dedicator of cytokinesis C/D, N-terminal [IPR021816]", "Dehydrogenase, E1 component [IPR001017]", "Deoxynucleoside kinase domain [IPR031314]", "Desmoplakin, SH3 domain [IPR041615]", "Desmoplakin, spectrin-like domain [IPR041573]", "Deubiquitinating enzyme MINDY-3/4, conserved domain [IPR025257]", "Diacylglycerol kinase, catalytic domain [IPR001206]", "Diacylglycerol/phorbol-ester binding [IPR020454]", "Diaphanous autoregulatory (DAD) domain [IPR014767]", "Dihydrofolate reductase domain [IPR001796]", "Dilute domain [IPR002710]", "Dipeptidyl peptidase 8 /9 ,N-terminal [IPR045785]", "Dipeptidylpeptidase IV, N-terminal domain [IPR002469]", "Dis3-like cold-shock domain 2 [IPR041505]", "Disulphide isomerase [IPR005788]", "DnaJ domain [IPR001623]", "DnaJ-like protein C11, C-terminal [IPR024586]", "Domain of unknown function DUF1087 [IPR009463]", "Domain of unknown function DUF1115 [IPR010541]", "Domain of unknown function DUF1605 [IPR011709]", "Domain of unknown function DUF1731 [IPR013549]", "Domain of unknown function DUF1747 [IPR013719]", "Domain of unknown function DUF1899 [IPR015048]", "Domain of unknown function DUF3350 [IPR021785]", "Domain of unknown function DUF3385, target of rapamycin protein [IPR024585]", "Domain of unknown function DUF3456 [IPR021852]", "Domain of unknown function DUF3480 [IPR022557]", "Domain of unknown function DUF3517 [IPR021905]", "Domain of unknown function DUF382 [IPR007180]", "Domain of unknown function DUF4149 [IPR025423]", "Domain of unknown function DUF4187 [IPR025239]", "Domain of unknown function DUF4195 [IPR025243]", "Domain of unknown function DUF4217 [IPR025313]", "Domain of unknown function DUF4749 [IPR031847]", "Domain of unknown function DUF5600 [IPR040990]", "Domain of unknown function DUF5921 [IPR045803]", "Double-stranded RNA-binding domain [IPR014720]", "Down-regulated-in-metastasis protein [IPR011430]", "Drebrin-like protein, SH3 domain [IPR035717]", "Dual specificity phosphatase, catalytic domain [IPR000340]", "Dual specificity protein phosphatase domain [IPR020422]", "Dynamin GTPase effector [IPR003130]", "Dynamin stalk domain [IPR000375]", "Dynamin, GTPase domain [IPR001401]", "Dynamin, N-terminal [IPR045063]", "Dynamin-like GTPase OPA1, C-terminal [IPR045817]", "Dynamin-type guanine nucleotide-binding (G) domain [IPR030381]", "Dynein associated protein [IPR022157]", "Dynein heavy chain AAA lid domain [IPR041658]", "Dynein heavy chain region D6 P-loop domain [IPR004273]", "Dynein heavy chain, AAA 5 extension domain [IPR041466]", "Dynein heavy chain, AAA module D4 [IPR024317]", "Dynein heavy chain, ATP-binding dynein motor region [IPR035706]", "Dynein heavy chain, C-terminal domain [IPR041228]", "Dynein heavy chain, coiled coil stalk [IPR024743]", "Dynein heavy chain, hydrolytic ATP-binding dynein motor region [IPR035699]", "Dynein heavy chain, linker [IPR013602]", "Dynein heavy chain, tail [IPR013594]", "Dyskerin-like [IPR012960]", "E2 binding [IPR014929]", "E3 ligase, CCCH-type zinc finger [IPR041367]", "E3 ubiquitin ligase EDD, ubiquitin-associated domain [IPR024725]", "E3 ubiquitin ligase UBR4, C-terminal [IPR025704]", "E3 ubiquitin ligase, domain of unknown function DUF908 [IPR010309]", "E3 ubiquitin ligase, domain of unknown function DUF913 [IPR010314]", "E3 ubiquitin-protein ligase CBL-B, RING finger, HC subclass [IPR039520]", "E3 ubiquitin-protein ligase UBR-like, C-terminal [IPR044046]", "E3 ubiquitin-protein ligase UBR4, N-terminal [IPR045841]", "EB1, C-terminal [IPR004953]", "EBP50, C-terminal [IPR015098]", "ECSIT, C-terminal domain [IPR029342]", "EF hand associated, type-1 [IPR013566]", "EF hand associated, type-2 [IPR013567]", "EF-hand domain [IPR002048]", "EF-hand domain, type 1 [IPR015153]", "EF-hand domain, type 2 [IPR015154]", "EF-hand, Ca insensitive [IPR014837]", "EFG, domain V [IPR035649]", "EGF-like calcium-binding domain [IPR001881]", "EGF-like domain [IPR000742]", "EGF-like domain, extracellular [IPR013111]", "EH domain [IPR000261]", "EH domain-containing protein, N-terminal [IPR031692]", "EIF2AK2, first double-stranded RNA binding domain [IPR044452]", "EIF2AK2, second double-stranded RNA binding domain [IPR044453]", "ELM2 domain [IPR000949]", "ELMO domain [IPR006816]", "ELMO, armadillo-like helical domain [IPR024574]", "ENTH domain [IPR013809]", "ER membrane protein complex subunit 1, C-terminal [IPR011678]", "ER membrane protein complex subunit 7, beta-sandwich domain [IPR019008]", "ERAP1-like C-terminal domain [IPR024571]", "ERM family, FERM domain C-lobe [IPR041789]", "ERV/ALR sulfhydryl oxidase domain [IPR017905]", "ERdj5, C-terminal thioredoxin domain [IPR035674]", "ERdj5, first thioredoxin domain [IPR035673]", "ERp29, N-terminal [IPR012883]", "EVE domain [IPR002740]", "EWS, RNA recognition motif [IPR034869]", "EXPERA domain [IPR033118]", "Electron transfer flavoprotein, alpha subunit, C-terminal [IPR014731]", "Electron transfer flavoprotein, alpha subunit, N-terminal [IPR033947]", "Electron transfer flavoprotein, alpha/beta-subunit, N-terminal [IPR014730]", "Electron transfer flavoprotein, beta subunit, N-terminal [IPR033948]", "Elongation Factor G, domain II [IPR041095]", "Elongation factor 1 beta central acidic region, eukaryote [IPR018940]", "Elongation factor 1B gamma, C-terminal [IPR001662]", "Elongation factor 4, domain IV [IPR035654]", "Elongation factor EFG, domain V-like [IPR000640]", "Elongation factor G, domain III [IPR009022]", "Elongation factor Tu (EF-Tu), GTP-binding domain [IPR041709]", "Elongation factor Tu, domain 2 [IPR033720]", "Elp3/MiaB/NifB [IPR006638]", "Emerin, LEM domain [IPR034989]", "Endonuclease/exonuclease/phosphatase [IPR005135]", "Endophilin-A, SH3 domain [IPR035824]", "Endophilin-B1, BAR domain [IPR035695]", "Endoplasmic reticulum resident protein 29, C-terminal [IPR011679]", "Endoplasmic reticulum vesicle transporter, C-terminal [IPR012936]", "Endoplasmic reticulum vesicle transporter, N-terminal [IPR039542]", "Enhancer of mRNA-decapping protein 4, WD40 repeat region [IPR032401]", "Enhancer of polycomb-like, N-terminal [IPR019542]", "Enolase, C-terminal TIM barrel domain [IPR020810]", "Enolase, N-terminal [IPR020811]", "Enoyl-CoA hydratase/isomerase domain [IPR045004]", "Ephrin receptor ligand binding domain [IPR001090]", "Ephrin receptor, transmembrane domain [IPR027936]", "Ephrin type-A receptor 7, ligand binding domain [IPR034283]", "Era-type guanine nucleotide-binding (G) domain [IPR030388]", "Eukaryotic Ribosomal Protein L27, KOW domain [IPR041991]", "Eukaryotic glycogen debranching enzyme, N-terminal domain [IPR029436]", "Eukaryotic translation initiation factor 2D, SUI1 domain [IPR039759]", "Eukaryotic translation initiation factor 3 subunit E, N-terminal [IPR019010]", "Eukaryotic translation initiation factor 3 subunit G, N-terminal [IPR024675]", "Exocyst complex component EXOC2/Sec5, N-terminal domain [IPR039481]", "Exonuclease 1-like, PIN-like domain [IPR044752]", "Exonuclease, RNase T/DNA polymerase III [IPR013520]", "Exonuclease-1, H3TH domain [IPR037315]", "Exoribonuclease, phosphorolytic domain 1 [IPR001247]", "Exoribonuclease, phosphorolytic domain 2 [IPR015847]", "Exosome complex component, N-terminal domain [IPR025721]", "Exosome complex exonuclease RRP44, S1 domain [IPR033770]", "Exosome-associated factor Rrp6, N-terminal [IPR012588]", "Exportin-1, C-terminal [IPR014877]", "Exportin-1/Importin-beta-like [IPR013598]", "Exportin-2, C-terminal [IPR005043]", "Exportin-2, central domain [IPR013713]", "Exportin-5, C-terminal domain [IPR045478]", "Exportin-T, C-terminal domain [IPR045546]", "Extended PHD (ePHD) domain [IPR034732]", "Extended synaptotagmin, C-terminal C2 domain [IPR037752]", "Extended synaptotagmin, C2A domain [IPR037733]", "Extended synaptotagmin, C2B domain [IPR037749]", "Extracellular Endonuclease, subunit A [IPR020821]", "F-BAR domain [IPR031160]", "F-box domain [IPR001810]", "FACT complex subunit POB3-like, N-terminal PH domain [IPR035417]", "FACT complex subunit Spt16 domain [IPR013953]", "FACT complex subunit Spt16, N-terminal lobe domain [IPR029148]", "FACT complex subunit Spt16, peptidase M24-like domain [IPR033825]", "FAD dependent oxidoreductase [IPR006076]", "FAD dependent oxidoreductase, central domain [IPR032503]", "FAD linked oxidase, N-terminal [IPR006094]", "FAD-binding domain, PCMH-type [IPR016166]", "FAD-binding domain, ferredoxin reductase-type [IPR017927]", "FAD-dependent oxidoreductase 2, FAD binding domain [IPR003953]", "FAD-linked oxidase, C-terminal [IPR004113]", "FAD/NAD(P)-binding domain [IPR023753]", "FAF1, UBA-like domain [IPR044541]", "FAM192A/Fyv6, N-terminal [IPR019331]", "FANCI helical domain 1 [IPR029310]", "FANCI helical domain 2 [IPR029312]", "FANCI solenoid 1 cap [IPR029305]", "FANCI solenoid 1 domain [IPR029308]", "FANCI solenoid 2 domain [IPR029315]", "FANCI solenoid 3 domain [IPR029313]", "FANCI solenoid 4 domain [IPR029314]", "FAS-associated factor 1-like, UBX domain [IPR033043]", "FAST kinase leucine-rich [IPR010622]", "FAST kinase-like protein, subdomain 2 [IPR013579]", "FATC domain [IPR003152]", "FCH domain [IPR001060]", "FCP1 homology domain [IPR004274]", "FDF domain [IPR019050]", "FERM adjacent (FA) [IPR014847]", "FERM central domain [IPR019748]", "FERM domain [IPR000299]", "FERM, C-terminal PH-like domain [IPR018980]", "FERM, N-terminal [IPR018979]", "FF domain [IPR002713]", "FFD box [IPR025761]", "FGFR1 oncogene partner (FOP), N-terminal dimerisation domain [IPR018993]", "FHOD1, N-terminal GTPase-binding domain [IPR041387]", "FIST, C-domain [IPR019494]", "FKBP-type peptidyl-prolyl cis-trans isomerase domain [IPR001179]", "FKBP12-rapamycin binding domain [IPR009076]", "FKBP3, basic tilted helix bundle domain [IPR041200]", "FY-rich, C-terminal [IPR003889]", "FY-rich, N-terminal [IPR003888]", "FYVE zinc finger [IPR000306]", "Far upstream element-binding protein, C-terminal [IPR015096]", "Fascin domain [IPR022768]", "Fatty acid hydroxylase [IPR006694]", "Fatty acyl-CoA reductase, C-terminal [IPR033640]", "Fatty acyl-coenzyme A reductase, NAD-binding domain [IPR013120]", "Fcf2 pre-rRNA processing, C-terminal [IPR014810]", "Ferrochelatase, C-terminal [IPR033644]", "Ferrochelatase, N-terminal [IPR033659]", "Fibronectin type II domain [IPR000562]", "Fibronectin type III [IPR003961]", "First polo-box domain [IPR033701]", "Flavodoxin-like [IPR001094]", "Flavodoxin/nitric oxide synthase [IPR008254]", "Flavoprotein pyridine nucleotide cytochrome reductase [IPR001709]", "Flavoprotein pyridine nucleotide cytochrome reductase-like, FAD-binding domain [IPR008333]", "Follistatin-like, N-terminal [IPR003645]", "Forkhead-associated (FHA) domain [IPR000253]", "Formin, FH2 domain [IPR015425]", "Formin, FH3 domain [IPR010472]", "Formin, GTPase-binding domain [IPR010473]", "Formyl transferase, N-terminal [IPR002376]", "Fragile X-related 1 protein, C-terminal core [IPR022034]", "Fragile X-related 1 protein, C-terminal region 1 [IPR032172]", "Fragile X-related 1 protein, C-terminal region 3 [IPR032177]", "Fragile X-related mental retardation protein, C-terminal region 2 [IPR032196]", "Fumarase C, C-terminal [IPR018951]", "Fumarate lyase, N-terminal [IPR022761]", "Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal [IPR015939]", "Fumarylacetoacetase, N-terminal [IPR015377]", "Fumarylacetoacetase-like, C-terminal [IPR011234]", "Fxr1, tudor domain [IPR041560]", "Fzo/mitofusin HR2 domain [IPR006884]", "G-patch domain [IPR000467]", "G-patch domain and KOW motifs-containing protein, KOW 1 [IPR041993]", "G-patch domain and KOW motifs-containing protein, KOW 2 [IPR041994]", "G-protein, beta subunit [IPR001632]", "G3BP1, RNA recognition motif [IPR034374]", "G3BP2, RNA recognition motif [IPR034376]", "GAD domain [IPR029351]", "GAR domain [IPR003108]", "GAT domain [IPR004152]", "GB1/RHD3-type guanine nucleotide-binding (G) domain [IPR030386]", "GCF, C-terminal [IPR022783]", "GH15-like domain [IPR011613]", "GHMP kinase N-terminal domain [IPR006204]", "GHMP kinase, C-terminal domain [IPR013750]", "GINS complex protein Sld5, alpha-helical domain [IPR038749]", "GINS subunit, domain A [IPR021151]", "GMP phosphodiesterase, delta subunit [IPR008015]", "GMP synthase, C-terminal [IPR001674]", "GMP synthase, glutamine amidotransferase [IPR004739]", "GMP synthetase ATP pyrophosphatase domain [IPR025777]", "GNAT domain [IPR000182]", "GOLD domain [IPR009038]", "GPAT/DHAPAT, acyltransferase domain [IPR041728]", "GPR domain [IPR000965]", "GRAM domain [IPR004182]", "GRASP-type PDZ domain [IPR024958]", "GRB2, C-terminal SH3 domain [IPR035643]", "GRB2, N-terminal SH3 domain [IPR035641]", "GRSF-1, RNA recognition motif 1 [IPR034425]", "GRSF-1, RNA recognition motif 2 [IPR034424]", "GRSF-1, RNA recognition motif 3 [IPR034426]", "GTP binding domain [IPR006073]", "GTP binding protein 1-like, GTP-binding domain [IPR035531]", "GTP binding protein, second domain [IPR031662]", "GTP-binding protein LepA, C-terminal [IPR013842]", "GTP-binding protein TrmE, N-terminal [IPR018948]", "GTP1/OBG domain [IPR006169]", "GTPase effector domain [IPR020850]", "GUCT [IPR012562]", "GYF domain [IPR003169]", "Galactokinase, N-terminal domain [IPR019539]", "Galactose mutarotase, N-terminal barrel [IPR031727]", "Galectin, carbohydrate recognition domain [IPR001079]", "Gamma tubulin complex component protein, N-terminal [IPR041470]", "Gamma tubulin complex component, C-terminal [IPR040457]", "Gamma-adaptin ear (GAE) domain [IPR008153]", "Gamma-glutamyl cyclotransferase-like [IPR013024]", "Gcp-like domain [IPR000905]", "Gelsolin-like domain [IPR007123]", "Gfo/Idh/MocA-like oxidoreductase, N-terminal [IPR000683]", "GlmS/AgaS, SIS domain 1 [IPR035466]", "GlmS/FrlB, SIS domain 2 [IPR035490]", "Glucosamine/galactosamine-6-phosphate isomerase [IPR006148]", "Glucose-6-phosphate dehydrogenase, C-terminal [IPR022675]", "Glucose-6-phosphate dehydrogenase, NAD-binding [IPR022674]", "Glucosidase 2 subunit beta-like [IPR036607]", "Glucosidase II beta subunit, N-terminal [IPR028146]", "Glucosyltransferase 24, catalytic domain [IPR040497]", "Glutamate/phenylalanine/leucine/valine dehydrogenase, C-terminal [IPR006096]", "Glutamate/phenylalanine/leucine/valine dehydrogenase, dimerisation domain [IPR006097]", "Glutaminase, EF-hand domain [IPR041541]", "Glutamine amidotransferase [IPR017926]", "Glutamine amidotransferase type 2 domain [IPR017932]", "Glutamine-Leucine-Glutamine, QLQ [IPR014978]", "Glutaminyl-tRNA synthetase, class Ib, non-specific RNA-binding domain 2 [IPR007638]", "Glutaminyl-tRNA synthetase, class Ib, non-specific RNA-binding domain, N-terminal [IPR007639]", "Glutamyl/glutaminyl-tRNA synthetase, class Ib, anti-codon binding domain [IPR020059]", "Glutamyl/glutaminyl-tRNA synthetase, class Ib, catalytic domain [IPR020058]", "Glutaredoxin [IPR002109]", "Glutaredoxin subgroup [IPR014025]", "Glutaredoxin, PICOT-like [IPR033658]", "Glutaredoxin, eukaryotic/virial [IPR011899]", "Glutathione S-transferase, C-terminal [IPR004046]", "Glutathione S-transferase, C-terminal-like [IPR010987]", "Glutathione S-transferase, N-terminal [IPR004045]", "Glutathione S-transferases, class Zeta , C-terminal [IPR034330]", "Glutathione S-transferases, class Zeta , N-terminal [IPR034333]", "Glutathione synthase, substrate-binding domain [IPR004887]", "Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain [IPR020828]", "Glyceraldehyde 3-phosphate dehydrogenase, catalytic domain [IPR020829]", "Glycerol-3-phosphate acyltransferase-like, C-terminal domain [IPR045520]", "Glycerophosphodiester phosphodiesterase domain [IPR030395]", "Glycine cleavage T-protein, C-terminal barrel domain [IPR013977]", "Glycogen debranching enzyme, C-terminal [IPR032790]", "Glycogen debranching enzyme, central domain [IPR032788]", "Glycogen debranching enzyme, glucanotransferase domain [IPR032792]", "Glycogen synthase kinase 3, catalytic domain [IPR039192]", "Glycoside hydrolase 35, catalytic domain [IPR031330]", "Glycoside hydrolase family 18, catalytic domain [IPR001223]", "Glycoside hydrolase family 2, catalytic domain [IPR006103]", "Glycoside hydrolase family 20, catalytic domain [IPR015883]", "Glycoside hydrolase family 31, N-terminal domain [IPR025887]", "Glycoside hydrolase family 38, N-terminal domain [IPR000602]", "Glycoside hydrolase family 38, central domain [IPR015341]", "Glycoside hydrolase, family 2, immunoglobulin-like beta-sandwich [IPR006102]", "Glycosyl hydrolase family 30, TIM-barrel domain [IPR033453]", "Glycosyl hydrolase family 30, beta sandwich domain [IPR033452]", "Glycosyl hydrolase family 38, C-terminal [IPR011682]", "Glycosyl hydrolase family 63, C-terminal [IPR031335]", "Glycosyl hydrolase family 63, N-terminal [IPR031631]", "Glycosyl hydrolase, family 13, catalytic domain [IPR006047]", "Glycosyl hydrolases family 2, sugar binding domain [IPR006104]", "Glycosyl hydrolases family 38, C-terminal beta sandwich domain [IPR041147]", "Glycosyl transferase CAP10 domain [IPR006598]", "Glycosyl transferase, family 1 [IPR001296]", "Glycosyltransferase 2-like [IPR001173]", "Glycyl-tRNA synthetase-like core domain [IPR033731]", "Glyoxalase domain-containing protein 4, C-terminal [IPR043194]", "Glyoxalase/fosfomycin resistance/dioxygenase domain [IPR004360]", "Growth hormone-inducible transmembrane protein [IPR035871]", "Guanine nucleotide exchange factor, N-terminal [IPR032691]", "Guanine nucleotide-binding protein-like 3, N-terminal domain [IPR014813]", "Guanylate kinase-like domain [IPR008144]", "Guanylate kinase/L-type calcium channel beta subunit [IPR008145]", "Guanylate-binding protein, N-terminal [IPR015894]", "Guanylate-binding protein/Atlastin, C-terminal [IPR003191]", "HAUS augmin-like complex subunit 3, N-terminal [IPR032733]", "HBS1-like protein, N-terminal [IPR015033]", "HD domain [IPR006674]", "HD/PDEase domain [IPR003607]", "HDGF-related, PWWP domain [IPR035496]", "HECT domain [IPR000569]", "HELLS, N-terminal [IPR044753]", "HHH domain 9 [IPR041692]", "HIRAN domain [IPR014905]", "HORMA domain [IPR003511]", "HR1 rho-binding domain [IPR011072]", "HRDC domain [IPR002121]", "HSPA4, nucleotide-binding domain [IPR042052]", "HSPA4L, nucleotide-binding domain [IPR042708]", "HSPH1, nucleotide-binding domain [IPR042053]", "HTH CenpB-type DNA-binding domain [IPR006600]", "HTTM [IPR011020]", "HUWE1, UBA domain [IPR041918]", "Heat shock 70kDa protein 14, nucleotide-binding domain [IPR042049]", "Heat shock chaperonin-binding [IPR006636]", "Heat shock protein DnaJ, cysteine-rich domain [IPR001305]", "Heat shock protein Hsp90, N-terminal [IPR020575]", "Heat shock protein beta-1, ACD domain [IPR037876]", "Heavy metal-associated domain, HMA [IPR006121]", "Heavy metal-associated domain, copper ion-binding [IPR006122]", "Helical and beta-bridge domain [IPR010643]", "Helicase domain [IPR007807]", "Helicase superfamily 1/2, ATP-binding domain [IPR014001]", "Helicase superfamily 1/2, ATP-binding domain, DinG/Rad3-type [IPR014013]", "Helicase, C-terminal [IPR001650]", "Helicase-associated domain [IPR007502]", "Helicase-like, DEXD box c2 type [IPR006554]", "Helicase/SANT-associated domain [IPR014012]", "Helicase/UvrB, N-terminal [IPR006935]", "Helix-hairpin-helix DNA-binding motif, class 1 [IPR003583]", "Helix-turn-helix DNA-binding domain of Spt6 [IPR028088]", "Hemimethylated DNA-binding domain [IPR011722]", "Hepatitis delta antigen (HDAg) domain [IPR037517]", "Heterogeneous nuclear ribonucleoprotein Q acidic domain [IPR041337]", "Heterogeneous nuclear ribonucleoprotein Q, RNA recognition motif 1 [IPR034544]", "Heterogeneous nuclear ribonucleoprotein Q, RNA recognition motif 2 [IPR034548]", "Heterogeneous nuclear ribonucleoprotein R, RNA recognition motif 2 [IPR034411]", "Heterogeneous nuclear ribonucleoprotein U, SPRY domain [IPR035778]", "Hexokinase, C-terminal [IPR022673]", "Hexokinase, N-terminal [IPR022672]", "HhH-GPD domain [IPR003265]", "High mobility group box domain 5 [IPR029215]", "High mobility group box domain [IPR009071]", "Histidine kinase domain [IPR005467]", "Histidine kinase/HSP90-like ATPase [IPR003594]", "Histone H2A, C-terminal domain [IPR032454]", "Histone H2A/H2B/H3 [IPR007125]", "Histone acetyl transferase HAT1 N-terminal [IPR019467]", "Histone deacetylase complex subunit SAP130, C-terminal domain [IPR031963]", "Histone deacetylase domain [IPR023801]", "Histone deacetylase interacting domain [IPR013194]", "Histone-arginine methyltransferase CARM1, N-terminal [IPR020989]", "Histone-binding protein RBBP4, N-terminal [IPR022052]", "HnRNP M, nuclear localisation signal [IPR024666]", "Homeobox domain [IPR001356]", "Homeobox domain, metazoa [IPR020479]", "Homocysteine-binding domain [IPR003726]", "Hotdog acyl-CoA thioesterase (ACOT)-type domain [IPR033120]", "HuR, RNA recognition motif 2 [IPR034996]", "Hyaluronan-mediated motility receptor, C-terminal [IPR031794]", "Hyaluronan/mRNA-binding protein [IPR006861]", "Hydroxymethylglutaryl-coenzyme A synthase, C-terminal domain [IPR013746]", "Hydroxymethylglutaryl-coenzyme A synthase, N-terminal [IPR013528]", "Hypoxia induced protein, domain [IPR007667]", "I-kappa-kinase-beta NEMO binding domain [IPR022007]", "I/LWEQ domain [IPR002558]", "IBR domain [IPR002867]", "IF2a, S1-like domain [IPR044126]", "IGF2BP1, RNA recognition motif 1 [IPR034837]", "IGF2BP1, RNA recognition motif 2 [IPR034842]", "IGF2BP2, RNA recognition motif 1 [IPR034843]", "IGF2BP3, RNA recognition motif 2 [IPR034844]", "IKBKB, scaffold dimerization domain [IPR041185]", "IMD/I-BAR domain [IPR013606]", "IMP dehydrogenase/GMP reductase [IPR001093]", "IPS1, CARD domain [IPR042144]", "IPT domain [IPR002909]", "IRG-type guanine nucleotide-binding (G) domain [IPR030385]", "IRS-type PTB domain [IPR002404]", "IRSp53, SH3 domain [IPR035594]", "ISWI, HAND domain [IPR015194]", "Immunoglobulin C1-set [IPR003597]", "Immunoglobulin I-set [IPR013098]", "Immunoglobulin V-set domain [IPR013106]", "Immunoglobulin [IPR013151]", "Immunoglobulin subtype 2 [IPR003598]", "Immunoglobulin subtype [IPR003599]", "Immunoglobulin-like domain [IPR007110]", "Impact, N-terminal [IPR001498]", "Importin-alpha, importin-beta-binding domain [IPR002652]", "Importin-beta, N-terminal domain [IPR001494]", "Initiation factor eIF-4 gamma, MA3 [IPR003891]", "Inner centromere protein, ARK-binding domain [IPR005635]", "Inositol polyphosphate 5-phosphatase, clathrin binding domain [IPR031995]", "Inositol polyphosphate-related phosphatase [IPR000300]", "Integrator complex subunit 11, MBL-fold [IPR041897]", "Integrator complex subunit 14, C-terminal [IPR045814]", "Integrin beta N-terminal [IPR033760]", "Integrin beta subunit, VWA domain [IPR002369]", "Integrin beta subunit, cytoplasmic domain [IPR014836]", "Integrin beta subunit, tail [IPR012896]", "Integrin beta, epidermal growth factor-like domain 1 [IPR040622]", "Interferon regulatory factor 2-binding protein 1 & 2, zinc finger [IPR022750]", "Intermediate filament head, DNA-binding domain [IPR006821]", "Intermediate filament, rod domain [IPR039008]", "Intracellular hyaluronan-binding protein 4, N-terminal domain [IPR032381]", "Intron-binding protein aquarius, N-terminal [IPR032174]", "Ion transporter-like, CBS domain [IPR044751]", "Iron sulphur domain-containing, mitoNEET, N-terminal [IPR019610]", "Iron-binding zinc finger, CDGSH type [IPR018967]", "Isochorismatase-like [IPR000868]", "Isoleucyl tRNA synthetase type 1, anticodon-binding domain [IPR033708]", "Isoleucyl tRNA synthetase type 2, anticodon-binding domain [IPR033709]", "Isopenicillin N synthase-like, Fe(2+) 2OG dioxygenase domain [IPR044861]", "Isopropylmalate dehydrogenase-like domain [IPR024084]", "JAB1/MPN/MOV34 metalloenzyme domain [IPR000555]", "JNK-interacting protein, leucine zipper II [IPR032486]", "JNK/Rab-associated protein-1, N-terminal [IPR019143]", "JmjC domain [IPR003347]", "Jumonji, helical domain [IPR041070]", "K Homology domain [IPR004087]", "K Homology domain, type 1 [IPR004088]", "K Homology domain, type 2 [IPR004044]", "KASH domain [IPR012315]", "KHDRBS, Qua1 domain [IPR032571]", "KMT2A, PHD domain 1 [IPR042023]", "KMT2A, PHD domain 2 [IPR042025]", "KMT2A, PHD domain 3 [IPR044133]", "KMT2A, ePHD domain [IPR041958]", "KOW [IPR005824]", "Kinesin motor domain [IPR001752]", "Kinesin-associated microtubule-binding domain [IPR025901]", "Kinesin-like [IPR022164]", "Kinesin-like protein Kif23, Arf6-interacting domain [IPR032384]", "Kinetochore protein Cenp-F/LEK1, Rb protein-binding domain [IPR018302]", "Kinetochore protein Nuf2, N-terminal [IPR005549]", "Kri1-like, C-terminal [IPR024626]", "Krr1, KH1 domain [IPR041174]", "Ku, C-terminal [IPR014893]", "Ku70/Ku80 C-terminal arm [IPR005160]", "Ku70/Ku80 beta-barrel domain [IPR006164]", "Ku70/Ku80, N-terminal alpha/beta [IPR005161]", "L27 domain [IPR004172]", "L27 domain, C-terminal [IPR014775]", "LAIKA domain [IPR045353]", "LARP4, RNA recognition motif [IPR034903]", "LARP5, RNA recognition motif [IPR034900]", "LEM domain [IPR003887]", "LEM-like domain [IPR013146]", "LETM1, ribosome-binding domain [IPR033122]", "LETM1-like [IPR011685]", "LIS1 homology motif [IPR006594]", "LSM domain, eukaryotic/archaea-type [IPR001163]", "LSM-interacting domain [IPR008669]", "La protein, xRRM domain [IPR014886]", "La-type HTH domain [IPR006630]", "Lactate/malate dehydrogenase, C-terminal [IPR022383]", "Lactate/malate dehydrogenase, N-terminal [IPR001236]", "Lamin tail domain [IPR001322]", "Lamin-B receptor of TUDOR domain [IPR019023]", "Lamina-associated polypeptide 2 alpha, C-terminal [IPR021623]", "Laminin G domain [IPR001791]", "Large proline-rich protein BAG6 [IPR021925]", "Lasp1, SH3 domain [IPR035630]", "Legume-like lectin [IPR005052]", "Lens epithelium-derived growth factor, integrase-binding domain [IPR021567]", "Lethal giant larvae homologue 2 [IPR013577]", "Leucine zipper, homeobox-associated [IPR003106]", "Leucine-rich repeat N-terminal domain [IPR000372]", "Linker histone H1/H5, domain H15 [IPR005818]", "Liprin-alpha, SAM domain repeat 1 [IPR037620]", "Liprin-alpha, SAM domain repeat 2 [IPR037621]", "Liprin-alpha, SAM domain repeat 3 [IPR037622]", "Listerin, zinc finger, RING-type [IPR039804]", "Lon, substrate-binding domain [IPR003111]", "Longin domain [IPR010908]", "Lsm14-like, N-terminal [IPR025609]", "Lsm16, N-terminal [IPR034107]", "LsmAD domain [IPR009604]", "Lysine-tRNA ligase, class II, N-terminal [IPR044136]", "Lysophosphatidylcholine acyltransferase LPCAT1-like [IPR045252]", "Lysyl-tRNA synthetase, class II, C-terminal [IPR018149]", "MAGE homology domain [IPR002190]", "MAM domain [IPR000998]", "MAN1, RNA recognition motif [IPR034394]", "MANSC domain [IPR013980]", "MATH/TRAF domain [IPR002083]", "MCM N-terminal domain [IPR027925]", "MCM OB domain [IPR033762]", "MCM domain [IPR001208]", "MCM, AAA-lid domain [IPR041562]", "MD-2-related lipid-recognition domain [IPR003172]", "MDM2-binding protein, N-terminal domain [IPR029421]", "MDM2-binding protein, central domain [IPR029420]", "MDN2-binding protein, C-terminal domain [IPR029418]", "MENTAL domain [IPR019498]", "MHC class I alpha chain, alpha1 alpha2 domains [IPR001039]", "MHC class I, alpha chain, C-terminal [IPR010579]", "MHC class I-like antigen recognition-like [IPR011161]", "MIA2, SH3 domain [IPR035555]", "MIF4G-like, type 1 [IPR015172]", "MIF4G-like, type 2 [IPR015174]", "MIF4G-like, type 3 [IPR003890]", "MIRO domain [IPR020860]", "MIT domain [IPR007330]", "MKI67 FHA domain-interacting nucleolar phosphoprotein, FHA Ki67 binding [IPR021043]", "MMS19, C-terminal [IPR024687]", "MMS19, N-terminal [IPR029240]", "MOSC, N-terminal beta barrel [IPR005303]", "MPN domain [IPR037518]", "MPP6, SH3 domain [IPR035603]", "MRG domain [IPR026541]", "MRH domain [IPR044865]", "MRPL44, double-stranded RNA binding domain [IPR044444]", "MTMR6, PH-GRAM domain [IPR035998]", "Macro domain [IPR002589]", "Mad3/Bub1 homology region 1 [IPR013212]", "Major facilitator superfamily domain [IPR020846]", "Major sperm protein (MSP) domain [IPR000535]", "Malectin domain [IPR021720]", "Malic enzyme, N-terminal domain [IPR012301]", "Malic enzyme, NAD-binding [IPR012302]", "Man1/Src1, C-terminal [IPR018996]", "Manganese/iron superoxide dismutase, C-terminal [IPR019832]", "Manganese/iron superoxide dismutase, N-terminal [IPR019831]", "Mannose-1-phosphate guanyltransferase, N-terminal domain [IPR045233]", "Mannosidase Ig/CBM-like domain [IPR041447]", "MaoC-like dehydratase domain [IPR002539]", "Marvel domain [IPR008253]", "Matrin-3, RNA recognition motif 1 [IPR034928]", "Matrin-3, RNA recognition motif 2 [IPR034930]", "Matrin/U1-C, C2H2-type zinc finger [IPR000690]", "Matrin/U1-C-like, C2H2-type zinc finger [IPR003604]", "Mcm6, C-terminal winged-helix domain [IPR041024]", "Mediator complex, subunit Med1 [IPR019680]", "Mediator complex, subunit Med25, NR box [IPR021406]", "Mediator complex, subunit Med25, PTOV domain [IPR021394]", "Mediator complex, subunit Med25, synapsin 1 [IPR021397]", "Mediator of RNA polymerase II transcription subunit 25, von Willebrand factor type A domain [IPR021419]", "Membrane insertase YidC/Oxa1, C-terminal [IPR028055]", "Metallo-beta-lactamase [IPR001279]", "Metastasis-associated protein MTA1, R1 domain [IPR035170]", "Metaxin, glutathione S-transferase domain [IPR033468]", "Methionine synthase, B12-binding domain [IPR033706]", "Methionine--tRNA ligase, N-terminal [IPR041598]", "Methioninyl-tRNA synthetase core domain [IPR033911]", "Methionyl-tRNA synthetase, anticodon-binding domain [IPR041872]", "Methionyl/Leucyl tRNA synthetase [IPR015413]", "Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding [IPR013155]", "Methyl-CpG DNA binding [IPR001739]", "Methyl-CpG binding protein 2/3, C-terminal domain [IPR025884]", "Methyl-CpG-binding domain protein 2/3, p55-binding region [IPR032343]", "Methylglyoxal synthase-like domain [IPR011607]", "Methyltransferase domain 25 [IPR041698]", "Methyltransferase type 11 [IPR013216]", "Methyltransferase type 12 [IPR013217]", "Mib-herc2 [IPR010606]", "Midasin AAA lid domain 5 [IPR041190]", "Midasin, AAA lid domain 7 [IPR040848]", "Midline-1, COS domain [IPR040859]", "Minichromosome loss protein Mcl1, middle region [IPR022100]", "Misato Segment II tubulin-like domain [IPR019605]", "Mitochondria fission protein Fis1, cytosolic domain [IPR033745]", "Mitochondrial apoptosis-inducing factor, C-terminal domain [IPR029324]", "Mitochondrial cytochrome c oxidase subunit VIc/VIIs [IPR034884]", "Mitochondrial degradasome RNA helicase subunit, C-terminal domain [IPR022192]", "Mitochondrial outer membrane transport complex Sam37/metaxin, N-terminal domain [IPR019564]", "Mitochondrial ribosomal protein L46 NUDIX [IPR033650]", "MnmE, helical domain [IPR025867]", "MoaB/Mog domain [IPR001453]", "Molybdenum cofactor sulfurase, C-terminal [IPR005302]", "Molybdopterin oxidoreductase [IPR006656]", "Molybdopterin oxidoreductase, 4Fe-4S domain [IPR006963]", "Mot1, ATP-binding domain [IPR044078]", "Mot1, central domain [IPR022707]", "Mre11 nuclease, N-terminal metallophosphatase domain [IPR041796]", "Mre11, DNA-binding [IPR007281]", "Mu homology domain [IPR028565]", "Mu2, C-terminal domain [IPR043512]", "Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal [IPR031717]", "Multiple myeloma tumor-associated protein 2-like, N-terminal [IPR019315]", "Multiprotein bridging factor 1, N-terminal [IPR013729]", "Myb domain [IPR017930]", "Myo-inositol-1-phosphate synthase, GAPDH-like [IPR013021]", "Myosin VI, cargo binding domain [IPR032412]", "Myosin head, motor domain [IPR001609]", "Myosin phosphatase-RhoA interacting protein, PH domain [IPR039597]", "Myosin tail [IPR002928]", "Myosin, N-terminal, SH3-like [IPR004009]", "Myotubularin-like phosphatase domain [IPR010569]", "Myristoyl-CoA:protein N-myristoyltransferase, C-terminal [IPR022677]", "Myristoyl-CoA:protein N-myristoyltransferase, N-terminal [IPR022676]", "N-acetylgalactosaminyltransferase [IPR045885]", "N-acetylneuraminic acid synthase, N-terminal [IPR013132]", "NAD(P) binding domain of glutamate dehydrogenase [IPR033922]", "NAD(P) transhydrogenase, alpha subunit, C-terminal [IPR024605]", "NAD(P)-binding domain [IPR016040]", "NAD-dependent epimerase/dehydratase [IPR001509]", "NAD/GMP synthase [IPR022310]", "NADH pyrophosphatase-like, N-terminal [IPR015375]", "NADH-quinone oxidoreductase, chain G, C-terminal [IPR015405]", "NADH-quinone oxidoreductase, subunit D [IPR001135]", "NADH-ubiquinone oxidoreductase 51kDa subunit, FMN-binding domain [IPR011538]", "NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain [IPR019575]", "NADH:ubiquinone oxidoreductase, 30kDa subunit [IPR001268]", "NADH:ubiquinone oxidoreductase, subunit G, iron-sulphur binding [IPR019574]", "NADH:ubiquinone oxidoreductase-like, 20kDa subunit [IPR006137]", "NADP transhydrogenase beta-like domain [IPR034300]", "NADP-dependent oxidoreductase domain [IPR023210]", "NDPK7, first NDPk domain [IPR035525]", "NDPK7, second NDPk domain [IPR037993]", "NECAP, PHear domain [IPR012466]", "NEDD8 ultimate buster 1, ubiquitin-like domain [IPR041207]", "NET domain [IPR027353]", "NF-kappaB-repression factor, R3H domain [IPR034071]", "NFACT protein, C-terminal [IPR021846]", "NFACT, RNA-binding domain [IPR008532]", "NFkappaB IPT domain [IPR033926]", "NGN domain [IPR005100]", "NGN domain, eukaryotic [IPR039385]", "NHL2, NHL repeat domain [IPR045302]", "NIF system FeS cluster assembly, NifU, C-terminal [IPR001075]", "NIF system FeS cluster assembly, NifU, N-terminal [IPR002871]", "NLE [IPR012972]", "NOG, C-terminal [IPR012973]", "NOG1, N-terminal helical domain [IPR041623]", "NOP5, N-terminal [IPR012974]", "NOPS [IPR012975]", "NOSIC [IPR012976]", "NOT2/NOT3/NOT5, C-terminal [IPR007282]", "NOT4, modified RING finger, HC subclass (C4C4-type) [IPR039515]", "NP60, PWWP domain [IPR035501]", "NPL4, zinc-binding putative [IPR007716]", "NSD, Cys-His rich domain [IPR041306]", "NUC153 [IPR012580]", "NUC205 domain [IPR012584]", "NUDIX hydrolase [IPR020476]", "NUDIX hydrolase domain [IPR000086]", "NVL2, nucleolin binding domain [IPR031996]", "Nascent polypeptide-associated complex NAC domain [IPR002715]", "Negative elongation factor E, RNA recognition motif [IPR034637]", "Neurobeachin-like, DUF1088 [IPR010508]", "Neurobeachin/BDCP, DUF4704 [IPR031570]", "Neuropilin, C-terminal [IPR022579]", "Nibrin, second BRCT domain [IPR032429]", "Nicastrin, small lobe [IPR041084]", "Nicotinamide phosphoribosyltransferase, N-terminal domain [IPR041529]", "Nicotinate/nicotinamide phosphoribosyltransferase [IPR041525]", "Niemann-Pick C1, N-terminal [IPR032190]", "Nin one binding (NOB1) Zn-ribbon-like [IPR014881]", "Nitric oxide synthase-interacting protein, zinc-finger [IPR031790]", "Nmd3, N-terminal [IPR007064]", "Non-canonical purine NTP phosphatase/PRRC1 [IPR026533]", "Nop domain [IPR002687]", "Nop2p [IPR011023]", "Novel protein kinase C delta, catalytic domain [IPR034667]", "Npc2 like, ML domain [IPR033916]", "Nrap protein domain 1 [IPR035082]", "Nrap protein, domain 2 [IPR035367]", "Nrap protein, domain 3 [IPR035368]", "Nrap protein, domain 4 [IPR035369]", "Nrap protein, domain 5 [IPR035370]", "Nrap protein, domain 6 [IPR035371]", "Nuclear RNA export factor Tap, RNA-binding domain [IPR015245]", "Nuclear condensin complex subunit 3, C-terminal domain [IPR025977]", "Nuclear migration protein nudC [IPR032572]", "Nuclear pore complex protein Nup214, phenylalanine-glycine (FG) domain [IPR041553]", "Nuclear pore complex, NUP2/50/61 [IPR015007]", "Nuclear pore localisation protein NPL4, C-terminal [IPR007717]", "Nuclear pore localisation protein Npl4, ubiquitin-like domain [IPR024682]", "Nuclear protein 96 [IPR021967]", "Nuclear transport factor 2 domain [IPR002075]", "Nuclear transport factor 2, eukaryote [IPR018222]", "Nucleolar GTP-binding protein 1, Rossman-fold domain [IPR010674]", "Nucleolar GTP-binding protein 2, N-terminal domain [IPR012971]", "Nucleolar complex-associated protein 3, N-terminal [IPR011501]", "Nucleolar pre-ribosomal-associated protein 1, C-terminal domain [IPR032436]", "Nucleolar pre-ribosomal-associated protein 1, N-terminal [IPR021714]", "Nucleolar protein 7, C-terminal [IPR012579]", "Nucleolin, RNA recognition motif 1 [IPR034230]", "Nucleolin, RNA recognition motif 2 [IPR034233]", "Nucleolin, RNA recognition motif 3 [IPR034234]", "Nucleolin, RNA recognition motif 4 [IPR034235]", "Nucleophosmin, C-terminal [IPR032569]", "Nucleoplasmin core domain [IPR024057]", "Nucleoporin Nup153, N-terminal [IPR013913]", "Nucleoporin Nup188, N-terminal [IPR018864]", "Nucleoporin Nup54, alpha-helical domain [IPR025712]", "Nucleoporin, NSP1-like, C-terminal [IPR007758]", "Nucleoporin, Nup133/Nup155-like, C-terminal [IPR007187]", "Nucleoporin, Nup133/Nup155-like, N-terminal [IPR014908]", "Nucleoprotein TPR/MLP1 [IPR012929]", "Nucleoredoxin, redox inactive TRX-like domain b' [IPR041861]", "Nucleoside diphosphate kinase-like domain [IPR034907]", "Nucleoside phosphorylase domain [IPR000845]", "Nucleotide exchange factor Fes1 [IPR013918]", "Nucleotidyl transferase domain [IPR005835]", "NudC N-terminal domain [IPR025934]", "NudC domain-containing protein 2, p23 domain [IPR037902]", "NuoE domain [IPR042128]", "Nup358/RanBP2 E3 ligase domain [IPR022011]", "Nup54, C-terminal interacting domain [IPR040985]", "NusG, N-terminal [IPR006645]", "O-GlcNAc transferase, C-terminal [IPR029489]", "OB-fold nucleic acid binding domain, AA-tRNA synthetase-type [IPR004365]", "OBG-type guanine nucleotide-binding (G) domain [IPR031167]", "OCRE domain [IPR041591]", "OCRL1, PH domain [IPR037787]", "OCRL1/INPP5B, INPP5c domain [IPR037793]", "OTU domain [IPR003323]", "Occludin homology domain [IPR010844]", "Orotate phosphoribosyl transferase domain [IPR004467]", "Orotidine 5'-phosphate decarboxylase domain [IPR001754]", "Ovarian carcinoma immunoreactive antigen domain [IPR009764]", "Oxidoreductase FAD/NAD(P)-binding [IPR001433]", "Oxidoreductase, N-terminal domain [IPR041694]", "Oxoglutarate/iron-dependent dioxygenase [IPR005123]", "P-type ATPase, haloacid dehalogenase domain [IPR044492]", "P-type trefoil domain [IPR000519]", "PA domain [IPR003137]", "PABP, RNA recognition motif 2 [IPR045305]", "PACSIN1/PACSIN2, SH3 domain [IPR035743]", "PACSIN2, F-BAR domain [IPR037453]", "PADR1 domain [IPR012982]", "PAP/25A-associated [IPR002058]", "PARN, R3H domain [IPR034042]", "PB1 domain [IPR000270]", "PCNA-associated factor, histone-like domain [IPR031444]", "PDIP3, RNA recognition motif [IPR034784]", "PDZ domain [IPR001478]", "PH-BEACH domain [IPR023362]", "PI31 proteasome regulator, N-terminal [IPR021625]", "PI31 proteasome regulator, C-terminal [IPR013886]", "PI3K-C2-alpha, catalytic domain [IPR037705]", "PIH1, N-terminal [IPR012981]", "PIH1D1/2/3, CS-like domain [IPR041442]", "PIK-related kinase [IPR014009]", "PIK-related kinase, FAT [IPR003151]", "PIN domain [IPR002716]", "PITH domain [IPR010400]", "PKD domain [IPR000601]", "PKD/Chitinase domain [IPR022409]", "PLAA family ubiquitin binding domain [IPR015155]", "PLC-gamma, C-terminal SH2 domain [IPR035023]", "PLC-gamma, N-terminal SH2 domain [IPR035024]", "PLD-like domain [IPR032803]", "POLO box domain [IPR000959]", "POPLD domain [IPR012590]", "POTRA domain [IPR034746]", "PP5, C-terminal metallophosphatase domain [IPR041753]", "PPIL4-like, cyclophilin domain [IPR035538]", "PPM-type phosphatase domain [IPR001932]", "PPP domain [IPR013235]", "PRKRA, first double-stranded RNA binding domain [IPR044465]", "PRKRA, second double-stranded RNA binding domain [IPR044466]", "PRKRA, third double-stranded RNA binding domain [IPR044467]", "PRMT5 arginine-N-methyltransferase [IPR035075]", "PRMT5, TIM barrel domain [IPR035247]", "PRMT5, oligomerisation domain [IPR035248]", "PRO8NT domain [IPR012591]", "PROCN domain [IPR012592]", "PROCT domain [IPR012984]", "PRP1 splicing factor, N-terminal [IPR010491]", "PRP8 domain IV core [IPR021983]", "PSF, NOPS domain [IPR034526]", "PSF, RNA recognition motif 1 [IPR034525]", "PSI domain [IPR016201]", "PSP, proline-rich [IPR006568]", "PSP1, RNA recognition motif 1 [IPR034522]", "PSP1, RNA recognition motif 2 [IPR034523]", "PTB/PI domain [IPR006020]", "PTBP1, RNA recognition motif 1 [IPR035000]", "PTBP1, RNA recognition motif 2-like [IPR021790]", "PTBP1, RNA recognition motif 3 [IPR035001]", "PTBP2, RNA recognition motif 1 [IPR035002]", "PTBP2, RNA recognition motif 3 [IPR034799]", "PTBP2, RNA recognition motif 4 [IPR034800]", "PUA domain [IPR002478]", "PUF60, RNA recognition motif 1 [IPR034209]", "PUF60, RNA recognition motif 2 [IPR034211]", "PUF60, RNA recognition motif 3 [IPR034212]", "PUL domain [IPR013535]", "PWI domain [IPR002483]", "PWWP domain [IPR000313]", "Paf1 complex subunit Cdc73, N-terminal domain [IPR032041]", "Pancreatic trypsin inhibitor Kunitz domain [IPR002223]", "Pentacotripeptide-repeat region of PRORP [IPR033443]", "Pep3/Vps18/deep orange [IPR007810]", "Peptidase C12, C-terminal domain [IPR041507]", "Peptidase C12, ubiquitin carboxyl-terminal hydrolase [IPR001578]", "Peptidase C19, ubiquitin carboxyl-terminal hydrolase [IPR001394]", "Peptidase C19, ubiquitin-specific peptidase, DUSP domain [IPR006615]", "Peptidase C1A, papain C-terminal [IPR000668]", "Peptidase C1A, propeptide [IPR012599]", "Peptidase C2, calpain, catalytic domain [IPR001300]", "Peptidase C2, calpain, domain III [IPR022683]", "Peptidase C2, calpain, large subunit, domain III [IPR022682]", "Peptidase M1, leukotriene A4 hydrolase/aminopeptidase C-terminal [IPR015211]", "Peptidase M1, membrane alanine aminopeptidase [IPR014782]", "Peptidase M13, C-terminal domain [IPR018497]", "Peptidase M13, N-terminal domain [IPR008753]", "Peptidase M14, carboxypeptidase A [IPR000834]", "Peptidase M16, C-terminal [IPR007863]", "Peptidase M16, N-terminal [IPR011765]", "Peptidase M16, middle/third domain [IPR032632]", "Peptidase M16C associated [IPR013578]", "Peptidase M17, leucyl aminopeptidase, C-terminal [IPR000819]", "Peptidase M17, leucyl aminopeptidase, N-terminal [IPR008283]", "Peptidase M20, dimerisation domain [IPR011650]", "Peptidase M24 [IPR000994]", "Peptidase M24, C-terminal domain [IPR032416]", "Peptidase M28 [IPR007484]", "Peptidase M3A/M3B catalytic domain [IPR001567]", "Peptidase M41 [IPR000642]", "Peptidase M41, FtsH extracellular [IPR011546]", "Peptidase M48 [IPR001915]", "Peptidase S16, Lon proteolytic domain [IPR008269]", "Peptidase S24/S26A/S26B/S26C [IPR015927]", "Peptidase S26 [IPR019533]", "Peptidase S53, activation domain [IPR015366]", "Peptidase S59, nucleoporin [IPR007230]", "Peptidase S8/S53 domain [IPR000209]", "Peptidase S8A, tripeptidyl peptidase II [IPR022229]", "Peptidase S9, prolyl oligopeptidase, catalytic domain [IPR001375]", "Peptidase S9A, N-terminal domain [IPR023302]", "Peptidyl-prolyl cis-trans isomerase, PpiC-type [IPR000297]", "Pericentriolar material 1 protein, C-terminal [IPR031446]", "Peripheral subunit-binding domain [IPR004167]", "Peroxiredoxin, C-terminal [IPR019479]", "Peroxisome membrane anchor protein Pex14p, N-terminal [IPR006785]", "PheRS DNA binding domain 2 [IPR040586]", "PheRS, DNA binding domain 1 [IPR040724]", "PheRS, DNA binding domain 3 [IPR040725]", "Phenylacetic acid degradation-related domain [IPR003736]", "Phenylalanine--tRNA ligase beta subunit, B1 domain [IPR040659]", "Phenylalanyl tRNA synthetase beta chain, core domain [IPR041616]", "Phenylalanyl-tRNA synthetase [IPR002319]", "Phosducin, thioredoxin-like domain [IPR024253]", "Phosphatidylinositol 3-/4-kinase, catalytic domain [IPR000403]", "Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain [IPR000341]", "Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha, PX domain [IPR042133]", "Phosphatidylinositol-4-phosphate 5-kinase, core [IPR002498]", "Phosphatidylinositol-specific phospholipase C, X domain [IPR000909]", "Phosphoadenosine phosphosulphate reductase [IPR002500]", "Phosphoenolpyruvate carboxykinase, C-terminal P-loop domain [IPR035077]", "Phosphoenolpyruvate carboxykinase, GTP-utilising, N-terminal [IPR035078]", "Phosphofructokinase domain [IPR000023]", "Phosphoglucose isomerase, SIS domain 1 [IPR035476]", "Phosphoglucose isomerase, SIS domain 2 [IPR035482]", "Phosphoinositide 3-kinase, accessory (PIK) domain [IPR001263]", "Phospholipase C, phosphatidylinositol-specific, Y domain [IPR001711]", "Phospholipase D-like domain [IPR025202]", "Phospholipase D/Transphosphatidylase [IPR001736]", "Phospholipase/carboxylesterase/thioesterase [IPR003140]", "Phospholipid/glycerol acyltransferase [IPR002123]", "Phosphopantetheine binding ACP domain [IPR009081]", "Phosphoribosylformylglycinamidine synthase, N-terminal [IPR040707]", "Phosphoribosylformylglycinamidine synthase, linker domain [IPR041609]", "Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain [IPR020561]", "Phosphoribosylglycinamide synthetase, C-domain [IPR020560]", "Phosphoribosylglycinamide synthetase, N-terminal [IPR020562]", "Phosphoribosyltransferase domain [IPR000836]", "Phosphoribulokinase/uridine kinase [IPR006083]", "Phosphorylase b kinase regulatory subunit alpha/beta, C-terminal domain [IPR045583]", "Phosphotyrosine protein phosphatase I [IPR023485]", "Phox homology [IPR001683]", "Pinin/SDK [IPR006787]", "Pinin/SDK/MemA protein [IPR006786]", "Pirin, C-terminal domain [IPR008778]", "Pirin, N-terminal domain [IPR003829]", "Pleckstrin homology domain 9 [IPR041681]", "Pleckstrin homology domain [IPR001849]", "Pleckstrin homology domain, spectrin-type [IPR001605]", "Plectin/S10, N-terminal [IPR005326]", "Polo-like kinase 1, catalytic domain [IPR033702]", "Poly(A) polymerase, RNA-binding domain [IPR007010]", "Poly(A) polymerase, central domain [IPR007012]", "Poly(A)-specific ribonuclease, RNA-binding [IPR014789]", "Poly(ADP-ribose) polymerase, catalytic domain [IPR012317]", "Poly(ADP-ribose) polymerase, regulatory domain [IPR004102]", "Polyadenylate-binding protein/Hyperplastic disc protein [IPR002004]", "Polyamine biosynthesis domain [IPR030374]", "Polycomb group protein, RNA binding region [IPR033763]", "Polycomb protein, VEFS-Box [IPR019135]", "Polyketide synthase, C-terminal extension [IPR032821]", "Polyketide synthase, beta-ketoacyl synthase domain [IPR020841]", "Polyketide synthase, dehydratase domain [IPR020807]", "Polyketide synthase, enoylreductase domain [IPR020843]", "Polyketide synthase, ketoreductase domain [IPR013968]", "Polyketide synthase, phosphopantetheine-binding domain [IPR020806]", "Polymerase, nucleotidyl transferase domain [IPR002934]", "Polypyrimidine tract-binding protein1/2/3, RNA recognition motif 2 [IPR034798]", "Polyribonucleotide 5'-hydroxyl-kinase Clp1, P-loop domain [IPR032319]", "Polyribonucleotide nucleotidyltransferase, RNA-binding domain [IPR015848]", "Polysaccharide biosynthesis domain [IPR021148]", "Pop1, N-terminal [IPR009723]", "Porphobilinogen deaminase, C-terminal [IPR022418]", "Porphobilinogen deaminase, N-terminal [IPR022417]", "Possible tRNA binding domain [IPR027992]", "Post-SET domain [IPR003616]", "Potassium channel tetramerisation-type BTB domain [IPR003131]", "Potentiating neddylation domain [IPR005176]", "Pre-PUA domain [IPR041366]", "Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term [IPR021718]", "Pre-mRNA polyadenylation factor Fip1 domain [IPR007854]", "Pre-mRNA processing factor 4 (PRP4)-like [IPR014906]", "Pre-mRNA splicing factor component Cdc5p/Cef1, C-terminal [IPR021786]", "Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding [IPR019581]", "Pre-mRNA-processing-splicing factor 8, U6-snRNA-binding [IPR019580]", "Pre-mRNA-splicing factor 19 [IPR013915]", "Pre-mRNA-splicing factor 3 [IPR013881]", "Pre-rRNA-processing protein Ipi1, N-terminal [IPR024679]", "Pre-rRNA-processing protein RIX1, N-terminal [IPR012583]", "Predicted HAD-superfamily phosphatase, subfamily IA/Epoxide hydrolase, N-terminal [IPR011945]", "Prenylcysteine lyase [IPR010795]", "Probable RNA-binding protein 19, RNA recognition motif 1 [IPR034418]", "Probable RNA-binding protein 19, RNA recognition motif 2 [IPR034417]", "Probable RNA-binding protein 19, RNA recognition motif 3 [IPR034419]", "Probable RNA-binding protein 19, RNA recognition motif 4 [IPR034420]", "Probable RNA-binding protein 19, RNA recognition motif 5 [IPR034423]", "Probable RNA-binding protein 19, RNA recognition motif 6 [IPR034421]", "Proliferating cell nuclear antigen, PCNA, C-terminal [IPR022649]", "Proliferating cell nuclear antigen, PCNA, N-terminal [IPR022648]", "Proline-tRNA ligase, class II, C-terminal [IPR016061]", "Prolyl 4-hydroxylase alpha subunit, Fe(2+) 2OG dioxygenase domain [IPR044862]", "Prolyl 4-hydroxylase alpha-subunit, N-terminal [IPR013547]", "Prolyl 4-hydroxylase, alpha subunit [IPR006620]", "Prolyl-tRNA synthetase, catalytic domain [IPR033721]", "Propionyl-coenzyme A carboxylase, BT domain [IPR041265]", "Prostaglandin E synthase 2, C-terminal [IPR034335]", "Proteasomal ATPase OB C-terminal domain [IPR032501]", "Proteasome activator Blm10, mid region [IPR032430]", "Proteasome activator PA28, C-terminal domain [IPR003186]", "Proteasome activator PA28, N-terminal domain [IPR003185]", "Proteasome activator complex subunit 4 C-terminal domain [IPR021843]", "Proteasome alpha-subunit, N-terminal domain [IPR000426]", "Proteasome beta subunit, C-terminal [IPR024689]", "Proteasome component (PCI) domain [IPR000717]", "Protein Kinase B beta, catalytic domain [IPR034677]", "Protein Kinase B, pleckstrin homology domain [IPR039026]", "Protein O-mannosyl-transferase TMTC, DUF1736 [IPR013618]", "Protein RED, C-terminal [IPR012492]", "Protein disulfide-isomerase A3, first redox inactive TRX-like domain b [IPR041868]", "Protein disulfide-isomerase A4, TRX-like domain b [IPR041866]", "Protein kinase C-like, phorbol ester/diacylglycerol-binding domain [IPR002219]", "Protein kinase domain [IPR000719]", "Protein kinase, C-terminal [IPR017892]", "Protein of unknown function DUF3504 [IPR021893]", "Protein of unknown function DUF3715 [IPR022188]", "Protein phosphatase 1 binding domain [IPR029334]", "Protein polybromo-1, Bromodomain 5 [IPR037968]", "Protein quaking, putative nuclear localisation signal [IPR032367]", "Protein-only RNase P, C-terminal [IPR031595]", "Protein-tyrosine phosphatase, catalytic [IPR003595]", "Prp31 C-terminal [IPR019175]", "Pseudouridine synthase I, TruA, alpha/beta domain [IPR020097]", "Pseudouridine synthase II, N-terminal [IPR002501]", "Pseudouridine synthase, TruD, insertion domain [IPR011760]", "Pterin-binding domain [IPR000489]", "Pumilio homology domain [IPR033133]", "PurE domain [IPR000031]", "PurM-like, C-terminal domain [IPR010918]", "PurM-like, N-terminal domain [IPR016188]", "Putative 5-3 exonuclease [IPR004859]", "Putative RNA methylase domain [IPR000241]", "Putative RNA-binding protein 27, RNA recognition motif [IPR034451]", "Putative WW-binding domain and destruction box [IPR033461]", "Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain [IPR004099]", "Pyridoxamine kinase/Phosphomethylpyrimidine kinase [IPR013749]", "Pyrroline-5-carboxylate reductase, catalytic, N-terminal [IPR028939]", "Pyrroline-5-carboxylate reductase, dimerisation domain [IPR029036]", "Pyruvate carboxyltransferase [IPR000891]", "Pyruvate kinase, C-terminal [IPR015795]", "Pyruvate kinase, barrel [IPR015793]", "R3H domain [IPR001374]", "RABX5, catalytic core helical domain [IPR041545]", "RAD23A/RAD23B, UBA1 domain [IPR041811]", "RAD50, zinc hook [IPR013134]", "RAP domain [IPR013584]", "RAWUL domain [IPR032443]", "RBM10, OCRE domain [IPR035618]", "RBM12, RNA recognition motif 1 [IPR034591]", "RBM12, RNA recognition motif 2 [IPR034594]", "RBM12, RNA recognition motif 3 [IPR034855]", "RBM12, RNA recognition motif 4 [IPR034856]", "RBM12, RNA recognition motif 5 [IPR034854]", "RBM12B, RNA recognition motif 2 [IPR034588]", "RBM12B, RNA recognition motif 3 [IPR034858]", "RBM14, RNA recognition motif 1 [IPR034506]", "RBM14, RNA recognition motif 2 [IPR034507]", "RBM1CTR [IPR012604]", "RBM25, RNA recognition motif [IPR034268]", "RBM26, RNA recognition motif 1 [IPR034859]", "RBM26-like, RNA recognition motif 2 [IPR039511]", "RBM3/CIRBP, RNA recognition motif [IPR034278]", "RBM34, RNA recognition motif 1 [IPR034220]", "RBM34, RNA recognition motif 2 [IPR034221]", "RBM4, RNA recognition motif 1 [IPR034897]", "RBM4, RNA recognition motif 2 [IPR034898]", "RBM8, RNA recognition motif [IPR033744]", "RDD [IPR010432]", "RED-like, N-terminal [IPR012916]", "REKLES domain [IPR023334]", "RH1 domain [IPR034743]", "RH2 domain [IPR034744]", "RII binding domain [IPR018459]", "RING-type zinc-finger, LisH dimerisation motif [IPR027370]", "RIO kinase [IPR000687]", "RIO2 kinase winged helix domain, N-terminal [IPR015285]", "RL domain [IPR041252]", "RLI, domain 1 [IPR034348]", "RNA 3'-terminal phosphate cyclase domain [IPR023797]", "RNA 3'-terminal phosphate cyclase, insert domain [IPR013791]", "RNA binding activity-knot of a chromodomain [IPR025995]", "RNA exonuclease 4, DEDDh 3'-5' exonuclease domain [IPR037431]", "RNA helicase UPF1, 1B domain [IPR040812]", "RNA helicase UPF1, Cys/His rich zinc-binding domain [IPR018999]", "RNA helicase, DEAD-box type, Q motif [IPR014014]", "RNA polymerase II-associated protein 1, C-terminal [IPR013929]", "RNA polymerase II-associated protein 1, N-terminal [IPR013930]", "RNA polymerase III Rpc82, C -terminal [IPR008806]", "RNA polymerase III subunit RPC82-related, helix-turn-helix [IPR013197]", "RNA polymerase Rpb1, domain 1 [IPR007080]", "RNA polymerase Rpb1, domain 3 [IPR007066]", "RNA polymerase Rpb1, domain 4 [IPR007083]", "RNA polymerase Rpb1, domain 5 [IPR007081]", "RNA polymerase Rpb1, domain 6 [IPR007075]", "RNA polymerase Rpb1, domain 7 [IPR007073]", "RNA polymerase Rpb2, domain 2 [IPR007642]", "RNA polymerase Rpb2, domain 3 [IPR007645]", "RNA polymerase Rpb2, domain 4 [IPR007646]", "RNA polymerase Rpb2, domain 5 [IPR007647]", "RNA polymerase Rpb2, domain 7 [IPR007641]", "RNA polymerase Rpb7-like , N-terminal [IPR005576]", "RNA polymerase, N-terminal [IPR006592]", "RNA polymerase, alpha subunit [IPR000722]", "RNA polymerase, beta subunit, protrusion [IPR007644]", "RNA recognition motif domain [IPR000504]", "RNA recognition motif domain, eukaryote [IPR003954]", "RNA recognition motif, spliceosomal PrP8 [IPR019582]", "RNA-binding S4 domain [IPR002942]", "RNA-binding domain, S1 [IPR022967]", "RNA-binding protein 10, RNA recognition motif 2 [IPR034992]", "RNA-binding protein 5, RNA recognition motif 1 [IPR034991]", "RNA-binding protein 5, RNA recognition motif 2 [IPR034993]", "RNA-binding protein Musashi homologue, RNA recognition motif 1 [IPR034130]", "RNA-binding protein Musashi homologue, RNA recognition motif 2 [IPR034126]", "RNA-polymerase II-associated protein 3-like, C-terminal domain [IPR025986]", "RNase L inhibitor RLI-like, possible metal-binding domain [IPR007209]", "ROCK, Rho binding domain [IPR015008]", "ROK, N-terminal [IPR012987]", "RPN1, N-terminal [IPR040892]", "RPN13, DEUBAD domain [IPR032368]", "RQC domain [IPR018982]", "RUN domain [IPR004012]", "RWD domain [IPR006575]", "RZZ complex, subunit KNTC1/ROD, C-terminal [IPR019527]", "Rab geranylgeranyltransferase, alpha subunit, insert-domain [IPR009087]", "Rab-GTPase-TBC domain [IPR000195]", "Rab3-GAP regulatory subunit, N-terminal [IPR032839]", "Rab3GAP regulatory subunit, C-terminal [IPR029257]", "Rad21/Rec8-like protein, C-terminal, eukaryotic [IPR006909]", "Rad21/Rec8-like protein, N-terminal [IPR006910]", "Rad50, ATP-binding cassette domain [IPR045171]", "Rad50/SbcC-type AAA domain [IPR038729]", "Radical SAM [IPR007197]", "Radical SAM, C-terminal extension [IPR032432]", "Raly, RNA recognition motif [IPR034502]", "Ran binding domain [IPR000156]", "Ran binding protein 9/10, SPRY domain [IPR035782]", "Ran-GTPase activating protein 1, C-terminal [IPR009109]", "Ran-specific GTPase-activating protein 1, Ran-binding domain [IPR045256]", "Rap1 Myb domain [IPR015010]", "Ras GTPase-activating domain [IPR001936]", "Ras guanine-nucleotide exchange factors catalytic domain [IPR001895]", "Ras-associating (RA) domain [IPR000159]", "Ras-like guanine nucleotide exchange factor, N-terminal [IPR000651]", "RasGAP protein, C-terminal [IPR000593]", "RecF/RecN/SMC, N-terminal [IPR003395]", "Redoxin [IPR013740]", "Regulator of MON1-CCZ1 complex, C-terminal [IPR009755]", "Rel homology dimerisation domain [IPR032397]", "Rel homology domain (RHD), DNA-binding domain [IPR011539]", "Replication factor A, C-terminal [IPR013955]", "Replication factor C, C-terminal [IPR013748]", "Replication factor-A protein 1, N-terminal [IPR007199]", "Replication protein A, C-terminal [IPR014892]", "Replication protein A, OB domain [IPR031657]", "Replication termination factor 2, RING-finger [IPR027799]", "Reticulon [IPR003388]", "Retinoblastoma-associated protein, A-box [IPR002720]", "Retinoblastoma-associated protein, B-box [IPR002719]", "Retinoblastoma-associated protein, C-terminal [IPR015030]", "Retinoblastoma-associated protein, N-terminal [IPR024599]", "Rho GTPase-activating protein domain [IPR000198]", "Rho GTPase-binding/formin homology 3 (GBD/FH3) domain [IPR014768]", "Rho-associated protein kinase 1, HR1 [IPR037310]", "Rho-associated protein kinase 2, HR1 domain [IPR037311]", "Rhodanese-like domain [IPR001763]", "Ribonuclease H1, N-terminal [IPR011320]", "Ribonuclease HII/HIII domain [IPR024567]", "Ribonuclease II/R [IPR001900]", "Ribonuclease, PIN domain [IPR033411]", "Ribonucleoprotein PTB-binding 1, RNA recognition motif 1 [IPR034633]", "Ribonucleotide reductase large subunit, C-terminal [IPR000788]", "Ribonucleotide reductase large subunit, N-terminal [IPR013509]", "Ribonucleotide reductase, class I , alpha subunit [IPR013346]", "Ribose-phosphate pyrophosphokinase, N-terminal domain [IPR029099]", "Ribosomal L28e/Mak16 [IPR029004]", "Ribosomal Protein L6, KOW domain [IPR041997]", "Ribosomal Proteins L2, RNA binding domain [IPR022666]", "Ribosomal RNA adenine methylase transferase, N-terminal [IPR020598]", "Ribosomal RNA methyltransferase FtsJ domain [IPR002877]", "Ribosomal RNA methyltransferase Spb1, domain of unknown function DUF3381 [IPR024576]", "Ribosomal RNA methyltransferase, Spb1, C-terminal [IPR012920]", "Ribosomal RNA small subunit methyltransferase F, N-terminal [IPR031341]", "Ribosomal RNA-processing protein 14/surfeit locus protein 6, C-terminal domain [IPR029190]", "Ribosomal S6 kinase, N-terminal catalytic domain [IPR041906]", "Ribosomal protein 50S-L18Ae/60S-L20/60S-L18A [IPR023573]", "Ribosomal protein L10e/L16 [IPR016180]", "Ribosomal protein L11, C-terminal [IPR020783]", "Ribosomal protein L11, N-terminal [IPR020784]", "Ribosomal protein L14, KOW motif [IPR041985]", "Ribosomal protein L14e domain [IPR002784]", "Ribosomal protein L18e/L15P [IPR021131]", "Ribosomal protein L19, eukaryotic [IPR033935]", "Ribosomal protein L19/L19e [IPR000196]", "Ribosomal protein L2, C-terminal [IPR022669]", "Ribosomal protein L23/L25, N-terminal [IPR005633]", "Ribosomal protein L26/L24, KOW domain [IPR041988]", "Ribosomal protein L30, N-terminal [IPR012988]", "Ribosomal protein L30, ferredoxin-like fold domain [IPR016082]", "Ribosomal protein L46, N-terminal [IPR021757]", "Ribosomal protein L5 eukaryotic, C-terminal [IPR025607]", "Ribosomal protein L5, C-terminal [IPR031309]", "Ribosomal protein L5, N-terminal [IPR031310]", "Ribosomal protein L6, N-terminal [IPR005568]", "Ribosomal protein L6, alpha-beta domain [IPR020040]", "Ribosomal protein L7, eukaryotic/archaeal [IPR035808]", "Ribosomal protein L7/L12, C-terminal [IPR013823]", "Ribosomal protein L7/L12, oligomerisation [IPR008932]", "Ribosomal protein L7Ae/L30e/S12e/Gadd45 [IPR004038]", "Ribosomal protein L9, N-terminal [IPR020070]", "Ribosomal protein S10 domain [IPR027486]", "Ribosomal protein S13/S15, N-terminal [IPR012606]", "Ribosomal protein S23/S25, mitochondrial [IPR023611]", "Ribosomal protein S24/S35, mitochondrial, conserved domain [IPR019349]", "Ribosomal protein S3, C-terminal [IPR001351]", "Ribosomal protein S4, KOW domain [IPR041982]", "Ribosomal protein S4/S9, N-terminal [IPR001912]", "Ribosomal protein S4e, N-terminal [IPR013843]", "Ribosomal protein S4e, central region [IPR013845]", "Ribosomal protein S5, C-terminal [IPR005324]", "Ribosomal protein S5, N-terminal [IPR013810]", "Ribosomal protein S6 kinase alpha-3, C-terminal catalytic domain [IPR041905]", "Ribosomal protein S7 domain [IPR023798]", "Ribosomal protein/NADH dehydrogenase domain [IPR007741]", "Ribosome biogenesis protein BMS1/TSR1, C-terminal [IPR007034]", "Ribosome biogenesis protein Bms1, N-terminal [IPR037875]", "Ribosome maturation protein Sdo1/SBDS, C-terminal [IPR018978]", "Ribosome maturation protein Sdo1/SBDS, N-terminal [IPR019783]", "Ribosome receptor lysine/proline rich [IPR007794]", "Ribosome-associated complex head domain [IPR032003]", "Ricin B, lectin domain [IPR000772]", "Right handed beta helix domain [IPR039448]", "RmlD-like substrate binding domain [IPR029903]", "Rpn11/EIF3F, C-terminal [IPR024969]", "Rpn13/ADRM1, Pru domain [IPR044868]", "RrmJ-type ribose 2-O-methyltransferase domain [IPR025816]", "Rrp40, S1 domain [IPR037319]", "Rrp44-like cold shock domain [IPR033771]", "RuvB-like, AAA-lid domain [IPR041048]", "S-adenosyl-L-homocysteine hydrolase, NAD binding domain [IPR015878]", "S-adenosylmethionine synthetase, C-terminal [IPR022630]", "S-adenosylmethionine synthetase, N-terminal [IPR022628]", "S-adenosylmethionine synthetase, central domain [IPR022629]", "S1 domain [IPR003029]", "S1-like RNA binding domain [IPR025223]", "S100/CaBP-9k-type, calcium binding, subdomain [IPR013787]", "SAB domain [IPR007477]", "SAC domain [IPR002013]", "SAF domain [IPR013974]", "SAICAR synthetase/ADE2, N-terminal [IPR028923]", "SAM domain [IPR041418]", "SAM-dependent methyltransferase RsmB/NOP2-type [IPR001678]", "SANT domain [IPR017884]", "SANT/Myb domain [IPR001005]", "SAP domain [IPR003034]", "SART3, RNA recognition motif 1 [IPR034217]", "SART3, RNA recognition motif 2 [IPR034218]", "SAS-6 coiled-coil domain [IPR041513]", "SCP2 sterol-binding domain [IPR003033]", "SEC23-interacting protein, SAM domain [IPR037603]", "SEP domain [IPR012989]", "SERRATE/Ars2 , C-terminal [IPR007042]", "SERRATE/Ars2, N-terminal [IPR021933]", "SET domain [IPR001214]", "SF3A2 domain [IPR031781]", "SF3A3 domain [IPR031774]", "SF3B4, RNA recognition motif 1 [IPR034158]", "SF3B4, RNA recognition motif 2 [IPR034159]", "SF3B6, RNA recognition motif [IPR034150]", "SGNH hydrolase-type esterase domain [IPR013830]", "SGS domain [IPR007699]", "SGTA, homodimerisation domain [IPR032374]", "SH2 domain [IPR000980]", "SH3 domain [IPR001452]", "SH3PXD2, PX domain [IPR037961]", "SH3PXD2B, SH3 domain 1 [IPR035477]", "SH3PXD2B, SH3 domain 2 [IPR035478]", "SH3PXD2B, SH3 domain 3 [IPR035479]", "SH3PXD2B, SH3 domain 4 [IPR035480]", "SHARP, RNA recognition motif 1 [IPR034172]", "SHARP, RNA recognition motif 2 [IPR034173]", "SHARP, RNA recognition motif 3 [IPR034174]", "SHARP, RNA recognition motif 4 [IPR034175]", "SIS domain [IPR001347]", "SKI-interacting protein SKIP, SNW domain [IPR004015]", "SKICH domain [IPR041611]", "SKP1 component, POZ domain [IPR016073]", "SKP1 component, dimerisation [IPR016072]", "SLC12A transporter, C-terminal [IPR018491]", "SLED domain [IPR021987]", "SLIDE domain [IPR015195]", "SLIRP, RNA recognition motif [IPR034152]", "SMARCA1, N-terminal [IPR044755]", "SMARCC, C-terminal [IPR032451]", "SMARCC, N-terminal [IPR032450]", "SMARCC, SWIRM-associated domain [IPR032448]", "SMCs flexible hinge [IPR010935]", "SMYD3, SET domain [IPR044420]", "SNARE-complex protein Syntaxin-18, N-terminal [IPR019529]", "SNF2, N-terminal [IPR000330]", "SNX2, PX domain [IPR037918]", "SNX27, PX domain [IPR037833]", "SNX27, RA domain [IPR037835]", "SNX27, atypical FERM-like domain [IPR037827]", "SNX5, PX domain [IPR042135]", "SNX6, PX domain [IPR042136]", "SNX9, SH3 domain [IPR035558]", "SPF45, RNA recognition motif [IPR034653]", "SPIN90, SH3 domain [IPR035514]", "SPIN90/Ldb17, leucine-rich domain [IPR018556]", "SPRY domain [IPR003877]", "SPRY-associated [IPR006574]", "SR140, RNA recognition motif [IPR035009]", "SRA-YDG [IPR003105]", "SRCR domain [IPR001190]", "SRCR-like domain [IPR017448]", "SREK1, RNA recognition motif 2 [IPR034192]", "SRP9 domain [IPR039432]", "SRSF1, RNA recognition motif 1 [IPR034520]", "SRSF6, RNA recognition motif 1 [IPR034511]", "SRSF7, RNA recognition motif [IPR034651]", "SRSF9, RNA recognition motif 1 [IPR034503]", "SRSF9, RNA recognition motif 2 [IPR034995]", "SSRP1 domain [IPR024954]", "STAG [IPR013721]", "STAM1, SH3 domain [IPR035657]", "STAMBP/STALP-like, MPN domain [IPR044098]", "STAR protein, homodimerisation region [IPR032377]", "STARD11, START domain [IPR041952]", "STARD7, START domain [IPR041949]", "START domain [IPR002913]", "STAT transcription factor, DNA-binding [IPR013801]", "STAT transcription factor, all-alpha domain [IPR013800]", "STAT transcription factor, protein interaction [IPR013799]", "STAT1, SH2 domain [IPR035859]", "STAT3, SH2 domain [IPR035855]", "STI1 domain [IPR041243]", "STRBP, first double-stranded RNA binding domain [IPR044472]", "SUI1 domain [IPR001950]", "SUMO-activating enzyme subunit 2, C-terminal domain [IPR032426]", "SUN coiled coil domain 2 [IPR040994]", "SUN domain [IPR012919]", "SUN domain-containing protein 1, N-terminal [IPR032680]", "SUZ-C domain [IPR024642]", "SWAP/Surp [IPR000061]", "SWI/SNF-like complex subunit BAF250, C-terminal [IPR033388]", "SWIB/MDM2 domain [IPR003121]", "SWIRM domain [IPR007526]", "Saccharopine dehydrogenase, NADP binding domain [IPR005097]", "Saccharopine dehydrogenase-like, C-terminal [IPR032095]", "Sam68, tyrosine-rich domain [IPR032335]", "Saposin A-type domain [IPR003119]", "Saposin B type domain [IPR008139]", "Saposin B type, region 2 [IPR008138]", "Saposin-like type B, region 1 [IPR007856]", "Scaffold protein Nfu/NifU, N-terminal [IPR014824]", "Schlafen group 3-like, DNA/RNA helicase domain [IPR018647]", "Schlafen, AlbA_2 domain [IPR007421]", "Sde2, N-terminal ubiquitin domain [IPR024974]", "Sec16, central conserved domain [IPR024340]", "Sec23, C-terminal [IPR037550]", "Sec23/Sec24 beta-sandwich [IPR012990]", "Sec23/Sec24, helical domain [IPR006900]", "Sec23/Sec24, trunk domain [IPR006896]", "Sec24-like, trunk domain [IPR041742]", "Sec63 domain [IPR004179]", "Sec7 domain [IPR000904]", "Second polo-box domain [IPR033695]", "Sedolisin domain [IPR030400]", "Senescence/spartin-associated, C-terminal [IPR009686]", "Sentrin-specific protease 3/5, conserved domain [IPR045577]", "Septin-type guanine nucleotide-binding (G) domain [IPR030379]", "Sequestosome-1, PB1 domain [IPR034866]", "Sequestosome-1, UBA domain [IPR033741]", "Serine aminopeptidase, S33 [IPR022742]", "Serine hydroxymethyltransferase-like domain [IPR039429]", "Serine-tRNA ligase catalytic core domain [IPR033729]", "Serine-tRNA synthetase, type1, N-terminal [IPR015866]", "Serine-threonine protein phosphatase, N-terminal [IPR031675]", "Serine-threonine/tyrosine-protein kinase, catalytic domain [IPR001245]", "Serine/arginine-rich splicing factor SRSF4-like, RNA recognition motif 1 [IPR035585]", "Serine/threonine-protein PRP4, catalytic domain [IPR044092]", "Serine/threonine-protein kinase N, C2 domain [IPR037784]", "Serine/threonine-protein kinase N, first HR1 domain [IPR037313]", "Serine/threonine-protein kinase Nek9, catalytic domain [IPR042767]", "Serine/threonine-protein kinase OSR1/WNK, CCT domain [IPR024678]", "Serine/threonine-protein kinase Rio2 [IPR030484]", "Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase [IPR006186]", "Serpin H1, serpin domain [IPR033830]", "Serpin domain [IPR023796]", "Siah interacting protein, N-terminal [IPR015120]", "Signal recognition particle SRP54, helical bundle [IPR013822]", "Signal recognition particle receptor, alpha subunit, N-terminal [IPR007222]", "Signal recognition particle subunit SRP68, RNA-binding domain [IPR034652]", "Signal recognition particle, SRP54 subunit, GTPase domain [IPR000897]", "Signal recognition particle, SRP54 subunit, M-domain [IPR004125]", "Signal recognition particle, SRP72 subunit, RNA-binding [IPR013699]", "Signal transducer and activation of transcription 1, TAZ2 binding domain, C-terminal [IPR022752]", "Sin3, C-terminal [IPR031693]", "Sister chromatid cohesion C-terminal domain [IPR024986]", "Ski2, N-terminal domain [IPR040801]", "Small G protein signalling modulator 1/2, Rab-binding domain [IPR021935]", "Small GTP-binding protein domain [IPR005225]", "Small nuclear ribonucleoprotein D1 [IPR034102]", "Small-subunit processome, Utp12 [IPR007148]", "Small-subunit processome, Utp13 [IPR013934]", "Small-subunit processome, Utp21 [IPR007319]", "Smc1, ATP-binding cassette domain [IPR028468]", "Smc2, ATP-binding cassette domain [IPR027120]", "Snf2, ATP coupling domain [IPR029295]", "Snu114, GTP-binding domain [IPR044121]", "Solute carrier family 3 member 2, N-terminal domain [IPR031984]", "Sortilin, C-terminal [IPR031777]", "Sortilin, N-terminal [IPR031778]", "Sorting Nexin 1, PX domain [IPR034901]", "Sorting nexin Vps5-like, C-terminal [IPR015404]", "Sorting nexin protein, WASP-binding domain [IPR019497]", "Sorting nexin, N-terminal [IPR005329]", "Sorting nexin-9, BAR domain [IPR037425]", "Sorting nexin-9, PX domain [IPR037426]", "Spen paralogue and orthologue SPOC, C-terminal [IPR012921]", "Spen paralogue/orthologue C-terminal, metazoa [IPR010912]", "Spermidine synthase, tetramerisation domain [IPR035246]", "Spindle assembly abnormal protein 6, N-terminal [IPR032396]", "Splicing factor 1, helix-hairpin domain [IPR032570]", "Splicing factor 3A subunit 1, conserved domain [IPR022030]", "Splicing factor 3A subunit 1, ubiquitin domain [IPR035563]", "Splicing factor 3B subunit 1 [IPR015016]", "Splicing factor ELAV/Hu, RNA recognition motif 1 [IPR034775]", "Splicing factor RBM39, linker [IPR029123]", "Splicing factor SF3a60 /Prp9 subunit, C-terminal [IPR024598]", "Splicing factor SF3a60 binding domain [IPR021966]", "Spp2/MOS2, G-patch domain [IPR026822]", "Spt5 C-terminal domain [IPR024945]", "Spt5 transcription elongation factor, N-terminal [IPR022581]", "Spt5, KOW domain repeat 1 [IPR041973]", "Spt5, KOW domain repeat 2 [IPR041975]", "Spt5, KOW domain repeat 3 [IPR041976]", "Spt5, KOW domain repeat 4 [IPR041977]", "Spt5, KOW domain repeat 5 [IPR041978]", "Spt5, KOW domain repeat 6 [IPR041980]", "Spt6 acidic, N-terminal domain [IPR028083]", "Spt6, SH2 domain [IPR035420]", "Spt6, SH2 domain, C terminus [IPR035018]", "Spt6, SH2 domain, N terminus [IPR035019]", "Squalene cyclase, C-terminal [IPR032696]", "Squalene cyclase, N-terminal [IPR032697]", "Squalene epoxidase [IPR013698]", "Srp40, C-terminal [IPR007718]", "StAR-related lipid transfer protein 3, C-terminal [IPR029867]", "Staphylococcal nuclease (SNase-like), OB-fold [IPR016071]", "Staufen 1, third double-stranded RNA binding domain [IPR044475]", "Staufen 2, first double-stranded RNA binding domain [IPR044476]", "Staufen 2, fourth double-stranded RNA binding domain [IPR044474]", "Staufen 2, second double-stranded RNA binding domain [IPR044464]", "Staufen 2, third double-stranded RNA binding domain [IPR044473]", "Staufen, C-terminal [IPR032478]", "Steadiness box (SB) domain [IPR017916]", "Sterile alpha motif domain [IPR001660]", "Sterol-sensing domain [IPR000731]", "Strictosidine synthase, conserved region [IPR018119]", "Stromalin conservative domain [IPR020839]", "Structural maintenance of chromosomes 3, ABC domain, eukaryotic [IPR041741]", "Structural maintenance of chromosomes 4, ABC domain, eukaryotic [IPR041738]", "Succinate dehydogenase/fumarate reductase N-terminal [IPR025192]", "Sulfatase, N-terminal [IPR000917]", "Sulfhydryl oxidase, Trx-like domain [IPR041269]", "Sulfhydryl oxidase, flavin adenine dinucleotide (FAD) binding domain [IPR040986]", "Sulphate adenylyltransferase [IPR002650]", "Sulphate adenylyltransferase catalytic domain [IPR024951]", "Suppressor of forked [IPR008847]", "Suppressor of white apricot, N-terminal domain [IPR019147]", "Survival motor neuron [IPR010304]", "Suv3, C-terminal domain 1 [IPR041082]", "Suv3, DEXQ-box helicase domain [IPR044774]", "Suv3, N-terminal [IPR041453]", "Symplekin C-terminal [IPR022075]", "Symplekin/Pta1, N-terminal [IPR032460]", "Synaptic functional regulator FMRP, KH0 domain [IPR040472]", "Synaptotagmin, SMP domain [IPR039010]", "Synaptotagmin-like mitochondrial-lipid-binding domain [IPR031468]", "Syntaxin, N-terminal domain [IPR006011]", "Syntaxin-5, N-terminal, Sly1p-binding domain [IPR021538]", "Syntaxin-8, SNARE domain [IPR041875]", "TAF6, C-terminal HEAT repeat domain [IPR011442]", "TAP C-terminal (TAP-C) domain [IPR005637]", "TAR DNA-binding protein 43, N-terminal [IPR041105]", "TATA box binding protein associated factor (TAF) [IPR004823]", "TATA-binding protein interacting (TIP20) [IPR013932]", "TBCE, ubiquitin-like (Ubl) domain [IPR044079]", "TCB1D9/TCB1D9B, PH-GRAM domain 1 [IPR036014]", "TCB1D9/TCB1D9B, PH-GRAM domain 2 [IPR036017]", "TFG box [IPR025768]", "TFG, PB1 domain [IPR034857]", "TGS [IPR004095]", "THADA/TRM732, DUF2428 [IPR019442]", "THIF-type NAD/FAD binding fold [IPR000594]", "THO complex subunit 2, N-terminal domain [IPR032302]", "THO complex, subunitTHOC2, C-terminal [IPR021418]", "THO complex, subunitTHOC2, N-terminal [IPR021726]", "THUMP domain [IPR004114]", "TIAR, RNA recognition motif 1 [IPR034492]", "TIAR, RNA recognition motif 2 [IPR034494]", "TIAR, RNA recognition motif 3 [IPR034496]", "TIF1-beta, RING finger, HC subclass [IPR042713]", "TIP49, P-loop domain [IPR010339]", "TNF receptor-associated factor 2, MATH domain [IPR037305]", "TNF receptor-associated factor, BIRC3 binding domain [IPR032070]", "TOG domain [IPR034085]", "TOPK, catalytic domain [IPR041989]", "TOPRIM domain [IPR006171]", "TPX2 central domain [IPR027330]", "TPX2, C-terminal [IPR027329]", "TRAM/LAG1/CLN8 homology domain [IPR006634]", "TRAM1-like protein [IPR013599]", "TRASH domain [IPR011017]", "TRF2-interacting telomeric protein/Rap1, C-terminal [IPR021661]", "TRIAD supradomain [IPR044066]", "TRIM21, PRY/SPRY domain [IPR035831]", "TRIM25, PRY/SPRY domain [IPR042753]", "TROVE domain [IPR008858]", "TSG101 and ALIX binding domain of CEP55 [IPR022008]", "TUG ubiquitin-like domain [IPR021569]", "TUTase nucleotidyltransferase domain [IPR045100]", "Talin, N-terminal F0 domain [IPR032425]", "Talin, central [IPR015224]", "Talin-1/2, rod-segment [IPR037438]", "Target SNARE coiled-coil homology domain [IPR000727]", "Telomere length regulation protein, conserved domain [IPR019337]", "Telomere-associated protein Rif1, N-terminal [IPR022031]", "Tensin phosphatase, C2 domain [IPR014020]", "Tensin-type phosphatase domain [IPR029023]", "Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain [IPR020631]", "Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain [IPR020630]", "Tetrapyrrole methylase [IPR000878]", "Tetratricopeptide repeat-like domain [IPR018704]", "Tetratricopeptide, SHNi-TPR domain [IPR019544]", "Tfc3, extended winged-helix domain [IPR035625]", "Thiamine pyrophosphate enzyme, C-terminal TPP-binding [IPR011766]", "Thiamine pyrophosphate enzyme, N-terminal TPP-binding domain [IPR012001]", "Thiamine pyrophosphate enzyme, central domain [IPR012000]", "Thioesterase [IPR001031]", "Thioesterase domain [IPR006683]", "Thiolase, C-terminal [IPR020617]", "Thiolase, N-terminal [IPR020616]", "Thioredoxin domain [IPR013766]", "Thioredoxin domain-containing protein 17-like domain [IPR010357]", "Thioredoxin-like fold [IPR012336]", "Thioredoxin-related transmembrane protein 2, thioredoxin domain [IPR037463]", "Threonine-tRNA ligase catalytic core domain [IPR033728]", "Threonyl/alanyl tRNA synthetase, SAD [IPR012947]", "Thymidylate kinase-like domain [IPR039430]", "Thymidylate synthase/dCMP hydroxymethylase domain [IPR023451]", "Tim10-like [IPR004217]", "Tim44-like domain [IPR007379]", "Toll-interacting protein, C2 domain [IPR037301]", "Toll-interacting protein, CUE domain [IPR041799]", "Topoisomerase I C-terminal domain [IPR025834]", "Trafficking protein particle complex subunit 11 [IPR021773]", "Trafficking protein particle complex subunit 11, C-terminal [IPR025876]", "Trans-isoprenyl diphosphate synthases, head-to-head [IPR033904]", "Transcription elongation factor S-II, central domain [IPR003618]", "Transcription elongation factor Spt6, YqgF domain [IPR028231]", "Transcription elongation factor Spt6, helix-hairpin-helix motif [IPR032706]", "Transcription elongation factor, TFIIS/CRSP70, N-terminal, sub-type [IPR003617]", "Transcription factor CBF/NF-Y/archaeal histone domain [IPR003958]", "Transcription factor CP2, SAM domain [IPR037599]", "Transcription factor IIIC, 90kDa subunit, N-terminal [IPR024761]", "Transcription factor IIIC, putative zinc-finger [IPR024764]", "Transcription factor IIS, N-terminal [IPR017923]", "Transcription termination and cleavage factor, C-terminal domain [IPR026896]", "Transcriptional coactivator p15 (PC4), C-terminal [IPR003173]", "Transcriptional repressor p66, coiled-coil MBD2-interaction domain [IPR032346]", "Transferrin receptor protein 1/2, PA domain [IPR037324]", "Transferrin receptor-like, dimerisation domain [IPR007365]", "Transforming acidic coiled-coil-containing protein, C-terminal [IPR007707]", "Transketolase, C-terminal domain [IPR033248]", "Transketolase, N-terminal [IPR005474]", "Transketolase-like, pyrimidine-binding domain [IPR005475]", "Translation elongation factor EF1B, beta/delta subunit, guanine nucleotide exchange domain [IPR014038]", "Translation elongation factor EFG/EF2, domain IV [IPR005517]", "Translation elongation factor EFTs/EF1B, dimerisation [IPR014039]", "Translation elongation factor EFTu-like, domain 2 [IPR004161]", "Translation elongation factor EFTu/EF1A, C-terminal [IPR004160]", "Translation elongation factor, IF5A C-terminal [IPR020189]", "Translation initiation factor IF- 2, domain 3 [IPR023115]", "Translation initiation factor IF2/IF5 domain [IPR002735]", "Translation initiation factor eIF-2B subunit epsilon, N-terminal [IPR035543]", "Translation initiation factor eIF-2B subunit epsilon, W2 domain [IPR044123]", "Translation initiation factor, beta propellor-like domain [IPR013979]", "Translational (tr)-type GTP-binding domain [IPR000795]", "Translationally controlled tumour protein (TCTP) domain [IPR034737]", "Translocon Sec61/SecY, plug domain [IPR019561]", "Treacle protein domain [IPR003993]", "Trimerisation motif [IPR015049]", "Tripartite DENN domain [IPR037516]", "Tripeptidyl-peptidase II domain [IPR034051]", "TrmE-type guanine nucleotide-binding domain [IPR031168]", "TryX and NRX, thioredoxin domain [IPR045870]", "Tubulin-folding cofactor B, N-terminal ubiquitin-like domain [IPR045172]", "Tubulin-specific chaperone D, C-terminal [IPR022577]", "Tubulin/FtsZ, 2-layer sandwich domain [IPR018316]", "Tubulin/FtsZ, GTPase domain [IPR003008]", "Tudor domain [IPR002999]", "Tyrosine-protein kinase BAZ1B, bromodomain [IPR037375]", "Tyrosine-protein kinase ephrin type A/B receptor-like [IPR011641]", "Tyrosine-protein kinase, catalytic domain [IPR020635]", "Tyrosine-specific protein phosphatase, PTPase domain [IPR000242]", "Tyrosine-specific protein phosphatases domain [IPR000387]", "U-box domain [IPR003613]", "U1 small nuclear ribonucleoprotein A, RNA recognition motif 1 [IPR034407]", "U1 small nuclear ribonucleoprotein A, RNA recognition motif 2 [IPR034409]", "U1 small nuclear ribonucleoprotein of 70kDa N-terminal [IPR022023]", "U1-C, C2H2-type zinc finger [IPR013085]", "U2A'/phosphoprotein 32 family A, C-terminal [IPR003603]", "U3 small nucleolar RNA-associated protein 10, N-terminal [IPR022125]", "U3 small nucleolar RNA-associated protein 15, C-terminal [IPR018983]", "UAS [IPR006577]", "UBX domain [IPR001012]", "UDP-glucose/GDP-mannose dehydrogenase, C-terminal [IPR014027]", "UDP-glucose/GDP-mannose dehydrogenase, N-terminal [IPR001732]", "UDP-glucose/GDP-mannose dehydrogenase, dimerisation [IPR014026]", "UDP-glucose:glycoprotein glucosyltransferase, thioredoxin-like domain 4 [IPR040525]", "UGGT, thioredoxin-like domain 1 [IPR040693]", "UGGT, thioredoxin-like domain 2 [IPR040694]", "UGGT, thioredoxin-like domain 3 [IPR040692]", "UHRF1, tandem tudor domain [IPR021991]", "UNC-45/Cro1/She4, central domain [IPR024660]", "USP8 dimerisation domain [IPR015063]", "UVR domain [IPR001943]", "Ubiquitin E2 variant, N-terminal [IPR008883]", "Ubiquitin carboxyl-terminal hydrolase 47, C-terminal [IPR045578]", "Ubiquitin carboxyl-terminal hydrolase 5, UBA1 domain [IPR041812]", "Ubiquitin carboxyl-terminal hydrolase 7, ICP0-binding domain [IPR024729]", "Ubiquitin carboxyl-terminal hydrolase, C-terminal [IPR029346]", "Ubiquitin conjugation factor E4, core [IPR019474]", "Ubiquitin specific protease domain [IPR028889]", "Ubiquitin system component CUE [IPR003892]", "Ubiquitin-activating enzyme E1, C-terminal [IPR018965]", "Ubiquitin-activating enzyme E1, FCCH domain [IPR032418]", "Ubiquitin-activating enzyme E1, four-helix bundle [IPR032420]", "Ubiquitin-activating enzyme, SCCH domain [IPR019572]", "Ubiquitin-associated domain [IPR015940]", "Ubiquitin-conjugating enzyme E2 [IPR000608]", "Ubiquitin-like domain [IPR000626]", "Ubiquitin-like domain, USP-type [IPR028135]", "Ubiquitin-specific peptidase 48 [IPR033841]", "Ubiquitin-specific-processing protease 48, Ubl domain [IPR044743]", "Ubiquitin/SUMO-activating enzyme ubiquitin-like domain [IPR028077]", "Ubiquitinyl hydrolase, variant UBP zinc finger [IPR041432]", "Ubiquitinyl hydrolase-L5 [IPR033837]", "Ulp1 protease family, C-terminal catalytic domain [IPR003653]", "Uncharacterised domain CHP00451 [IPR004521]", "Uncharacterised domain NUC173 [IPR012978]", "Uncharacterised domain NUC202 [IPR012980]", "Uroporphyrinogen decarboxylase (URO-D) [IPR000257]", "Uso1/p115-like vesicle tethering protein, C-terminal [IPR006955]", "VASP tetramerisation [IPR014885]", "VHS domain [IPR002014]", "VIP36, lectin domain [IPR035664]", "VPS10 [IPR006581]", "VPS9 domain [IPR003123]", "Vacuolar protein sorting-associated protein 4, MIT domain [IPR045253]", "Valyl tRNA synthetase, anticodon-binding domain [IPR033705]", "Vertebrate SNX3, PX domain [IPR042137]", "Vertebrate ubiquitin-conjugating enzyme E2 K, UBA domain [IPR042599]", "Vesicle tethering protein Uso1/P115-like , head domain [IPR006953]", "Vicinal oxygen chelate (VOC) domain [IPR037523]", "Vinculin-binding site-containing domain [IPR015009]", "Vitamin B12-dependent methionine synthase, activation domain [IPR004223]", "Vitamin K epoxide reductase [IPR012932]", "Vps16, C-terminal [IPR006925]", "Vps16, N-terminal [IPR006926]", "Vps4 oligomerisation, C-terminal [IPR015415]", "Vps53-like, N-terminal [IPR007234]", "W2 domain [IPR003307]", "WAPL domain [IPR012502]", "WD repeat-containing protein 18, C-terminal domain [IPR026987]", "WGR domain [IPR008893]", "WH1/EVH1 domain [IPR000697]", "WHEP-TRS domain [IPR000738]", "WHIM1 domain [IPR028942]", "WHIM2 domain [IPR028941]", "WSTF/Acf1/Cbp146 [IPR013136]", "WW domain [IPR001202]", "WWE domain [IPR004170]", "Wings apart-like protein, C-terminal [IPR022771]", "Wolframin, EF-hand domain [IPR045460]", "Wolframin, OB-fold domain [IPR045461]", "Wolframin, cysteine-rich domain [IPR045400]", "XPC-binding domain [IPR015360]", "XPG, N-terminal [IPR006085]", "XPG-I domain [IPR006086]", "XRN2-binding (XTBD) domain [IPR021859]", "Xrn1, helical domain [IPR041412]", "YKT6, SNARE motif [IPR045848]", "YTH domain [IPR007275]", "YchF, C-terminal domain [IPR013029]", "YchF, N-terminal [IPR041706]", "YjeF N-terminal domain [IPR004443]", "YqgF/RNase H-like domain [IPR006641]", "YrdC-like domain [IPR006070]", "Z-binding domain [IPR042371]", "ZAP, helix turn helix N-terminal domain [IPR041360]", "ZAP, zinc finger [IPR040954]", "ZC3H15/TMA46 family, C-terminal [IPR032378]", "ZO-1, SH3 domain [IPR035597]", "ZU5 domain [IPR000906]", "Zasp-like motif [IPR006643]", "Zinc finger C2H2 AKAP95-type [IPR034736]", "Zinc finger C2H2-type [IPR013087]", "Zinc finger, B-box, chordata [IPR020457]", "Zinc finger, C2H2, LYAR-type [IPR014898]", "Zinc finger, C3HC4 RING-type [IPR018957]", "Zinc finger, CCCH-type [IPR000571]", "Zinc finger, CCHC-type [IPR001878]", "Zinc finger, CHCC-type [IPR019401]", "Zinc finger, CHHC-type [IPR012996]", "Zinc finger, CW-type [IPR011124]", "Zinc finger, CXXC-type [IPR002857]", "Zinc finger, ClpX C4-type [IPR010603]", "Zinc finger, DNA-directed DNA polymerase, family B, alpha [IPR015088]", "Zinc finger, FPG/IleRS-type [IPR010663]", "Zinc finger, FYVE-related [IPR017455]", "Zinc finger, GATA-type [IPR000679]", "Zinc finger, GRF-type [IPR010666]", "Zinc finger, LIM-type [IPR001781]", "Zinc finger, MYM-type [IPR010507]", "Zinc finger, MYND-type [IPR002893]", "Zinc finger, PARP-type [IPR001510]", "Zinc finger, PHD-finger [IPR019787]", "Zinc finger, PHD-type [IPR001965]", "Zinc finger, RING-CH-type [IPR011016]", "Zinc finger, RING-type [IPR001841]", "Zinc finger, RanBP2-type [IPR001876]", "Zinc finger, Sec23/Sec24-type [IPR006895]", "Zinc finger, TFIIS-type [IPR001222]", "Zinc finger, TRAF-type [IPR001293]", "Zinc finger, UBP-type [IPR001607]", "Zinc finger, UBR-type [IPR003126]", "Zinc finger, ZPR1-type [IPR004457]", "Zinc finger, ZZ-type [IPR000433]", "Zinc finger, double-stranded RNA binding [IPR022755]", "Zinc knuckle CX2CX3GHX4C [IPR025829]", "Zinc ribbon, NADH pyrophosphatase [IPR015376]", "Zinc-finger CCCH domain [IPR041686]", "Zn-dependent metallo-hydrolase, RNA specificity domain [IPR011108]", "cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain [IPR003117]", "dUTPase, trimeric [IPR033704]", "dUTPase-like [IPR029054]", "eIF3 subunit M, C-terminal helix domain [IPR040750]", "eIF3B, RNA recognition motif [IPR034363]", "eIF3G, RNA recognition motif [IPR034240]", "eIF3h, C-terminal [IPR045810]", "eIF4H, RNA recognition motif [IPR034229]", "eRF1 domain 1/Pelota-like [IPR005140]", "eRF1 domain 2 [IPR005141]", "eRF1 domain 3 [IPR005142]", "hnRNP A0, RNA recognition motif 1 [IPR034801]", "hnRNP A1, RNA recognition motif 1 [IPR034845]", "hnRNP A1, RNA recognition motif 2 [IPR034803]", "hnRNP A2/B1, RNA recognition motif 1 [IPR034486]", "hnRNP A3, RNA recognition motif 1 [IPR034513]", "hnRNP A3, RNA recognition motif 2 [IPR034516]", "hnRNP DL, RNA recognition motif 1 [IPR034847]", "hnRNP-L, RNA recognition motif 1 [IPR035005]", "hnRNP-L, RNA recognition motif 2 [IPR035008]", "hnRNP-L, RNA recognition motif 3 [IPR034816]", "hnRNP-L, RNA recognition motif 4 [IPR034817]", "hnRNPAB, RNA recognition motif 1 [IPR034846]", "hnRNPH3, RNA recognition motif 2 [IPR034970]", "hnRNPH3, RNA recognition motif 3 [IPR034969]", "hnRNPM, RNA recognition motif 3 [IPR034990]", "hnRPLL, RNA recognition motif 1 [IPR034985]", "hnRPLL, RNA recognition motif 2 [IPR034986]", "hnRPLL, RNA recognition motif 3 [IPR034983]", "hnRPLL, RNA recognition motif 4 [IPR034987]", "mRNA decay factor PAT1 domain [IPR019167]", "mRNA splicing factor Cwf21 domain [IPR013170]", "p21 activated kinase binding domain [IPR033923]", "p21-activated kinase 2, catalytic domain [IPR035064]", "p53 transactivation domain [IPR013872]", "p53, DNA-binding domain [IPR011615]", "p53, tetramerisation domain [IPR010991]", "p54nrb, RNA recognition motif 1 [IPR034552]", "rRNA-processing arch domain [IPR025696]", "snRNP70, RNA recognition motif [IPR034143]", "tRNA methyltransferase TRM10-type domain [IPR028564]", "tRNA methyltransferase TRMD/TRM10-type domain [IPR016009]", "tRNA pseudouridylate synthase B, C-terminal [IPR032819]", "tRNA synthetase, B5-domain [IPR005147]", "tRNA synthetases class I, catalytic domain [IPR032678]", "tRNA(Met) cytidine acetyltransferase TmcA, N-terminal [IPR013562]", "tRNA-binding domain [IPR002547]", "tRNase Z endonuclease [IPR027794]", "v-SNARE, coiled-coil homology domain [IPR042855]", "von Willebrand factor, type A [IPR002035]"], "available_proteins": ["AARS", "AARS2", "AASDHPPT", "AATF", "ABCB1", "ABCB7", "ABCD3", "ABCE1", "ABCF1", "ABCF2", "ABCF3", "ABHD10", "ABHD12", "ABHD14B", "ABHD6", "ABI1", "ABRAXAS2", "ACAA2", "ACACA", "ACACB", "ACAD9", "ACADM", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACIN1", "ACLY", "ACO2", "ACOT13", "ACOT7", "ACOT9", "ACOX1", "ACOX3", "ACP1", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTN1", "ACTN2", "ACTN4", "ADAR", "ADD1", "ADD3", "ADH5", "ADK", "ADNP", "ADRM1", "ADSL", "AFDN", "AFG3L2", "AGK", "AGL", "AGPAT1", "AGPS", "AHCY", "AHCYL1", "AHNAK", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK2", "AK3", "AKAP1", "AKAP12", "AKAP13", "AKAP8", "AKAP8L", "AKR1A1", "AKR1B1", "AKR7A2", "AKT2", "ALDH16A1", "ALDH18A1", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALG1", "ALKBH5", "AMOT", "ANAPC1", "ANAPC10", "ANAPC5", "ANKLE2", "ANKRD17", "ANLN", "ANP32A", "ANP32B", "AP1B1", "AP1G1", "AP1M1", "AP1S2", "AP2A1", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "APEH", "APEX1", "APEX2", "APLP2", "APMAP", "APP", "APRT", "AQR", "ARCN1", "ARF4", "ARFGAP1", "ARFGAP2", "ARFIP1", "ARFIP2", "ARHGAP17", "ARHGEF2", "ARID1A", "ARID3B", "ARIH1", "ARIH2", "ARL1", "ARL2", "ARL3", "ARMC10", "ARMCX3", "ARMT1", "ARSA", "ASAH1", "ASCC2", "ASCC3", "ASH2L", "ASNA1", "ASNS", "ASPH", "ASPSCR1", "ATAD1", "ATAD3A", "ATAD3B", "ATIC", "ATL2", "ATP13A1", "ATP1A1", "ATP2A2", "ATP2C1", "ATP5A1", "ATP5B", "ATP6V1A", "ATP6V1B2", "ATP6V1H", "ATP7B", "ATXN10", "ATXN2L", "AUP1", "AURKA", "BAG3", "BAG5", "BAG6", "BAIAP2", "BAZ1A", "BAZ1B", "BCAP31", "BCAS3", "BCS1L", "BIRC6", "BLVRA", "BMS1", "BOP1", "BPTF", "BRAP", "BRD1", "BRD2", "BRIX1", "BSG", "BTAF1", "BTF3", "BUB1B", "BUD23", "BZW1", "BZW2", "C1orf35", "CACUL1", "CACYBP", "CAD", "CALCOCO1", "CALM3", "CALU", "CAMK1", "CAMK2G", "CAND1", "CAND2", "CAP1", "CAPN1", "CAPN2", "CAPNS1", "CAPRIN1", "CARM1", "CARS", "CASK", "CBL", "CBX1", "CBX2", "CBX3", "CBX5", "CCAR1", "CCAR2", "CCNB1", "CCNB2", "CD2AP", "CDC20", "CDC23", "CDC25C", "CDC34", "CDC37", "CDC42", "CDC5L", "CDC73", "CDCA8", "CDK1", "CDK2", "CDK4", "CDK5", "CDK6", "CDKN2AIP", "CDX2", "CEBPZ", "CENPF", "CEP55", "CERS2", "CETN2", "CFAP20", "CFL1", "CFL2", "CHAC2", "CHAF1A", "CHAF1B", "CHAMP1", "CHD4", "CHERP", "CHID1", "CHORDC1", "CHRAC1", "CHUK", "CIAPIN1", "CIRBP", "CISD2", "CIZ1", "CKAP2", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLASP2", "CLCN3", "CLCN7", "CLIC1", "CLIC4", "CLINT1", "CLIP1", "CLPB", "CLPX", "CLTC", "CLUH", "CMTR1", "CNDP2", "CNN2", "CNN3", "CNNM4", "CNOT1", "CNOT2", "CNOT3", "CNOT4", "CNPY2", "COIL", "COL4A3BP", "COLEC12", "COMMD2", "COPA", "COPB1", "COPB2", "COPG1", "COPG2", "COPS2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS7A", "COPS7B", "COPS8", "COPZ1", "COQ8A", "COQ9", "CORO1A", "CORO1C", "CORO7", "COTL1", "COX2", "COX6C", "CPD", "CPNE1", "CPNE3", "CPSF1", "CPSF3", "CPSF6", "CPSF7", "CPT2", "CRK", "CRKL", "CRYZ", "CSDE1", "CSE1L", "CSK", "CSNK1A1", "CSNK2A1", "CSNK2A2", "CSTB", "CSTF1", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTBS", "CTNNBL1", "CTPS1", "CTPS2", "CTSB", "CTSC", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CWF19L1", "CXADR", "CYB5B", "CYB5D2", "CYB5R1", "CYB5R3", "CYFIP1", "DARS", "DARS2", "DAZAP1", "DBN1", "DBNL", "DCAF1", "DCTN1", "DCUN1D4", "DDB1", "DDI2", "DDX1", "DDX10", "DDX17", "DDX18", "DDX20", "DDX21", "DDX23", "DDX24", "DDX27", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX50", "DDX51", "DDX52", "DDX54", "DDX56", "DDX6", "DEK", "DENR", "DFFA", "DHCR24", "DHFR", "DHX15", "DHX16", "DHX29", "DHX30", "DHX36", "DHX37", "DHX8", "DHX9", "DIAPH1", "DIAPH2", "DIAPH3", "DIDO1", "DIMT1", "DIS3", "DKC1", "DLAT", "DLD", "DLST", "DNA2", "DNAAF5", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC2", "DNAJC3", "DNAJC7", "DNAJC8", "DNAJC9", "DNM1L", "DNM2", "DNMT1", "DNTTIP2", "DOCK7", "DPH5", "DPM1", "DPP9", "DPYSL2", "DPYSL5", "DR1", "DRG1", "DRG2", "DSC1", "DSC3", "DSG2", "DSP", "DST", "DSTN", "DTYMK", "DUSP12", "DUSP3", "DUSP9", "DUT", "DYNC1H1", "DYNC2H1", "ECE1", "ECI2", "ECSIT", "EDC3", "EDC4", "EDF1", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EFHD1", "EFL1", "EFTUD2", "EHD1", "EHD4", "EIF2A", "EIF2AK2", "EIF2B3", "EIF2B5", "EIF2D", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A3", "EIF4B", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "ELAC2", "ELAVL1", "ELMO2", "ELMOD2", "ELOA", "ELOB", "ELOC", "ELP3", "EMC1", "EMC7", "EMD", "ENAH", "ENDOD1", "ENO1", "ENO2", "EPB41", "EPB41L2", "EPB41L5", "EPHA7", "EPHX1", "EPHX2", "EPRS", "EPS15", "EPS15L1", "ERAL1", "ERAP1", "ERCC2", "ERGIC3", "ERI1", "ERLIN1", "ERLIN2", "ERMP1", "ERP29", "ESF1", "ESYT1", "ETF1", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXO1", "EXOC2", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "EZR", "FAF1", "FAF2", "FAH", "FAHD1", "FAM129B", "FAM192A", "FAM208A", "FAM49B", "FAM8A1", "FANCI", "FAR1", "FARSA", "FARSB", "FASN", "FBXO22", "FBXO7", "FCGRT", "FDFT1", "FECH", "FEN1", "FGFR1OP", "FH", "FHOD1", "FIP1L1", "FIS1", "FKBP10", "FKBP14", "FKBP1A", "FKBP3", "FKBP4", "FKBP5", "FKBP7", "FKBP8", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FMR1", "FOXRED1", "FSCN1", "FTO", "FTSJ3", "FUBP1", "FUBP3", "FUCA1", "FUCA2", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GAK", "GALK1", "GALNT1", "GALNT2", "GALNT7", "GANAB", "GAPDH", "GAPVD1", "GARS", "GART", "GATAD2A", "GBA", "GBF1", "GCAT", "GCDH", "GCFC2", "GCLM", "GCN1", "GDPD1", "GEMIN5", "GFM1", "GFPT1", "GGCT", "GGCX", "GHITM", "GIGYF2", "GINS3", "GINS4", "GLA", "GLB1", "GLDC", "GLO1", "GLOD4", "GLRX", "GLRX3", "GLRX5", "GLS", "GLUD1", "GLYR1", "GM2A", "GMFB", "GMPPB", "GMPS", "GNL1", "GNL2", "GNL3", "GNL3L", "GNPAT", "GNPDA1", "GNS", "GOLGB1", "GOPC", "GORASP2", "GOT1", "GOT2", "GPAM", "GPATCH11", "GPATCH4", "GPD2", "GPI", "GPKOW", "GPS1", "GRB2", "GRHPR", "GRSF1", "GRWD1", "GSK3B", "GSPT1", "GSR", "GSS", "GSTK1", "GSTM3", "GSTO1", "GSTZ1", "GTF3C1", "GTF3C4", "GTPBP1", "GTPBP10", "GTPBP3", "GTPBP4", "GUF1", "GUSB", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACD3", "HACL1", "HADH", "HADHA", "HADHB", "HAT1", "HAUS3", "HBS1L", "HCFC1", "HDAC2", "HDGF", "HDGFL2", "HDLBP", "HEATR1", "HECTD1", "HECTD3", "HELLS", "HEXA", "HEXB", "HIBADH", "HIBCH", "HIF1AN", "HIGD2A", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HLTF", "HMBS", "HMGB1", "HMGB2", "HMGB3", "HMGCS1", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPLL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HNRNPUL2", "HP1BP3", "HPRT1", "HSD17B4", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA14", "HSPA4", "HSPA4L", "HSPB1", "HSPBP1", "HSPH1", "HTATIP2", "HUWE1", "IARS", "IARS2", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDI1", "IFT27", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IK", "ILF2", "ILF3", "ILKAP", "ILVBL", "IMP4", "IMPACT", "IMPDH1", "IMPDH2", "INA", "INCENP", "INTS11", "INTS14", "INTS9", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IRF2BPL", "IRGQ", "IRS4", "ISCU", "ISOC1", "ISYNA1", "ITGB1", "ITM2C", "IVD", "KARS", "KCTD12", "KCTD5", "KDELC2", "KDM1A", "KDM1B", "KDM3B", "KHDRBS1", "KHSRP", "KIAA0319L", "KIAA0391", "KIAA1147", "KIF11", "KIF15", "KIF18B", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF4A", "KIF5B", "KIF7", "KIFC1", "KMT2A", "KNTC1", "KPNA1", "KPNA2", "KPNA3", "KPNB1", "KRI1", "KRR1", "KTN1", "LAP3", "LARP1", "LARP4", "LARP4B", "LARS", "LARS2", "LASP1", "LBR", "LCLAT1", "LDHA", "LDHB", "LEMD2", "LEMD3", "LETM1", "LGALS3", "LGALS3BP", "LIG1", "LIG3", "LIMA1", "LIPA", "LLGL1", "LMAN1", "LMAN2", "LMNA", "LMNB1", "LMNB2", "LNPEP", "LONP1", "LPCAT1", "LPGAT1", "LRBA", "LRPPRC", "LRRC47", "LSM12", "LSM14B", "LSM2", "LSM6", "LSM7", "LSS", "LTA4H", "LTN1", "LYAR", "LYPLA1", "M6PR", "MACF1", "MAD2L1", "MAGED2", "MAN2A1", "MAN2B1", "MANBA", "MANF", "MAP2K1", "MAPK1", "MAPRE1", "MAPRE2", "MARC1", "MARS", "MAT2A", "MAT2B", "MATR3", "MAVS", "MBD3", "MCAT", "MCCC1", "MCCC2", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCU", "MDC1", "MDH1", "MDH2", "MDN1", "ME1", "MECP2", "MED1", "MED25", "MFN2", "MFSD10", "MIA2", "MICU1", "MID1", "MINDY3", "MIPEP", "MKI67", "MKRN2", "MLEC", "MMS19", "MOGS", "MORF4L1", "MORF4L2", "MOSPD2", "MOV10", "MPP6", "MPRIP", "MPST", "MRE11", "MRPL11", "MRPL12", "MRPL15", "MRPL39", "MRPL44", "MRPL45", "MRPL46", "MRPL48", "MRPL9", "MRPS23", "MRPS25", "MRPS35", "MRPS5", "MRPS7", "MRTO4", "MSH2", "MSH3", "MSH6", "MSI2", "MSN", "MSTO1", "MTA1", "MTA2", "MTAP", "MTBP", "MTHFD1", "MTHFD1L", "MTHFD2", "MTMR2", "MTMR6", "MTOR", "MTPAP", "MTR", "MTX1", "MTX2", "MVK", "MYH10", "MYH14", "MYH9", "MYL6", "MYO1B", "MYO1C", "MYO1D", "MYO6", "NAA40", "NAA50", "NAE1", "NAGLU", "NAMPT", "NANS", "NARS", "NASP", "NAT10", "NAXE", "NBN", "NCAPD2", "NCAPG", "NCBP1", "NCKIPSD", "NCL", "NCLN", "NCSTN", "NDUFA10", "NDUFA9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS6", "NDUFS7", "NDUFV1", "NDUFV2", "NECAP1", "NECAP2", "NEFL", "NEFM", "NEK9", "NELFA", "NELFE", "NEMF", "NENF", "NES", "NFU1", "NHLRC2", "NHP2", "NIFK", "NIPBL", "NKRF", "NLE1", "NLN", "NMD3", "NME1", "NME6", "NME7", "NMT1", "NNT", "NOB1", "NOC3L", "NOC4L", "NOL10", "NOL11", "NOL6", "NOL7", "NOL9", "NOLC1", "NOM1", "NONO", "NOP2", "NOP56", "NOP58", "NOSIP", "NPC1", "NPC2", "NPEPPS", "NPLOC4", "NPM1", "NRDC", "NRP1", "NSD2", "NSDHL", "NSF", "NSFL1C", "NSUN2", "NSUN5", "NTHL1", "NTPCR", "NUB1", "NUCB1", "NUCB2", "NUDC", "NUDCD2", "NUDT1", "NUDT12", "NUDT21", "NUDT5", "NUF2", "NUP133", "NUP153", "NUP155", "NUP188", "NUP210", "NUP214", "NUP50", "NUP54", "NUP62", "NUP98", "NUPL2", "NVL", "NXF1", "NXN", "OCIAD1", "OCLN", "OCRL", "OGDH", "OGT", "OLA1", "OPA1", "OSBP", "OSBPL8", "OSBPL9", "OSGEP", "OTUB1", "OXA1L", "OXSR1", "P3H1", "P4HA1", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PAFAH1B1", "PAFAH1B2", "PAFAH1B3", "PAICS", "PAK1", "PAK2", "PANK4", "PAPOLA", "PAPSS1", "PARK7", "PARN", "PARP1", "PATL1", "PBDC1", "PBK", "PBRM1", "PC", "PCBP1", "PCBP2", "PCCA", "PCK2", "PCLAF", "PCM1", "PCNA", "PCYOX1", "PDAP1", "PDCD11", "PDCD4", "PDCD6", "PDCD6IP", "PDCL3", "PDE12", "PDE6D", "PDHA1", "PDHB", "PDIA3", "PDIA4", "PDIA6", "PDK1", "PDK3", "PDLIM1", "PDLIM3", "PDLIM5", "PDLIM7", "PDPR", "PDXK", "PEF1", "PELO", "PELP1", "PEPD", "PES1", "PEX14", "PFAS", "PFKL", "PFKM", "PFKP", "PGD", "PGLS", "PGM1", "PGM2", "PGM3", "PGRMC1", "PGRMC2", "PHB", "PHB2", "PHF14", "PHF6", "PHF8", "PHGDH", "PHIP", "PHKA1", "PICALM", "PIH1D1", "PIK3C2A", "PIK3R4", "PIN1", "PIN4", "PIP4K2C", "PIR", "PITHD1", "PITRM1", "PKM", "PKMYT1", "PKN2", "PLAA", "PLCG1", "PLD3", "PLD6", "PLEC", "PLK1", "PLOD1", "PLOD2", "PLS3", "PM20D2", "PMPCA", "PMPCB", "PNN", "PNO1", "PNP", "PNPT1", "POGZ", "POLA1", "POLA2", "POLD1", "POLD2", "POLDIP2", "POLDIP3", "POLE", "POLE3", "POLE4", "POLR1A", "POLR1B", "POLR2A", "POLR2B", "POLR2C", "POLR2G", "POLR3A", "POLR3C", "POLRMT", "POP1", "POR", "PPAN", "PPAT", "PPFIA1", "PPIB", "PPID", "PPIF", "PPIG", "PPIH", "PPIL4", "PPM1G", "PPME1", "PPP1CA", "PPP1CB", "PPP1R10", "PPP1R7", "PPP4C", "PPP4R1", "PPP5C", "PPP6C", "PQBP1", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREP", "PREPL", "PRKAG1", "PRKAR1A", "PRKAR2A", "PRKCD", "PRKCSH", "PRKDC", "PRKRA", "PRMT1", "PRMT3", "PRMT5", "PRPF19", "PRPF3", "PRPF31", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPS1", "PRPSAP1", "PRPSAP2", "PRRC1", "PRRC2A", "PRRC2C", "PSAP", "PSAT1", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD11", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD6", "PSMD7", "PSMD8", "PSME1", "PSME2", "PSME3", "PSME4", "PSMF1", "PSPC1", "PTBP1", "PTBP2", "PTCD1", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK7", "PTPN1", "PTPN11", "PUF60", "PUM3", "PUS1", "PUS7", "PWP2", "PYCR1", "PYCR2", "QARS", "QKI", "QSOX2", "RAB10", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB21", "RAB23", "RAB24", "RAB2A", "RAB35", "RAB3GAP2", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RAB8A", "RABGAP1", "RABGGTA", "RAC1", "RACGAP1", "RAD21", "RAD23A", "RAD23B", "RAD50", "RALA", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP9", "RANGAP1", "RAP2B", "RAPGEF2", "RARS", "RARS2", "RAVER1", "RB1", "RBBP4", "RBBP6", "RBBP7", "RBM10", "RBM12", "RBM12B", "RBM14", "RBM17", "RBM19", "RBM22", "RBM25", "RBM26", "RBM27", "RBM28", "RBM3", "RBM34", "RBM39", "RBM4", "RBM5", "RBM8A", "RBMX", "RCL1", "RCN1", "RCN2", "RCOR1", "RDX", "RECQL", "RELA", "REPS1", "REXO4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RHEB", "RHOT1", "RHOT2", "RIF1", "RIOK2", "RIOX1", "RMC1", "RNASEH2A", "RNF2", "RNF40", "RNPEP", "ROCK1", "ROCK2", "RPA1", "RPA2", "RPAP1", "RPAP3", "RPF2", "RPL10", "RPL11", "RPL12", "RPL14", "RPL18", "RPL18A", "RPL19", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL30", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS2", "RPS20", "RPS3", "RPS4X", "RPS5", "RPS6KA1", "RPS6KA3", "RPS9", "RPSA", "RRBP1", "RRM1", "RRP12", "RSF1", "RSL24D1", "RTFDC1", "RTN3", "RTN4", "RUFY1", "RUVBL1", "RUVBL2", "RWDD1", "S100A10", "S100A11", "S100A13", "SACM1L", "SAE1", "SAFB", "SAFB2", "SAMHD1", "SAMM50", "SAP130", "SAR1A", "SARNP", "SARS", "SARS2", "SART3", "SASS6", "SBDS", "SC5D", "SCCPDH", "SCML2", "SCO2", "SCP2", "SCRIB", "SDCBP", "SDE2", "SDF4", "SDHA", "SDHB", "SDR39U1", "SEC11A", "SEC16A", "SEC22B", "SEC23A", "SEC23IP", "SEC24A", "SEC24B", "SEC24C", "SEC24D", "SEC31A", "SEC61A1", "SEC63", "SEL1L", "SENP3", "SEPHS1", "SEPT2", "SEPT7", "SEPT9", "SERBP1", "SERPINB6", "SERPINH1", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFSWAP", "SGTA", "SH3GL1", "SH3GLB1", "SH3PXD2B", "SHCBP1", "SHMT1", "SHMT2", "SIN3A", "SKIV2L", "SKIV2L2", "SKP1", "SKP2", "SLC12A2", "SLC12A9", "SLC16A1", "SLC25A12", "SLC25A13", "SLC25A24", "SLC27A2", "SLC27A4", "SLC38A2", "SLC3A2", "SLC4A1AP", "SLC4A7", "SLC9A3R1", "SLFN11", "SLIRP", "SLIT2", "SLK", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCC1", "SMARCC2", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC6", "SMCHD1", "SMN1*", "SMNDC1", "SMU1", "SMYD3", "SND1", "SNRNP200", "SNRNP70", "SNRPA", "SNRPA1", "SNRPC", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNW1", "SNX1", "SNX2", "SNX27", "SNX3", "SNX5", "SNX6", "SNX9", "SOD2", "SON", "SORT1", "SPAG9", "SPART", "SPATA5", "SPATA5L1", "SPC25", "SPEN", "SPNS1", "SPPL2A", "SPTAN1", "SPTBN1", "SPTBN2", "SPTLC1", "SPTLC2", "SQLE", "SQSTM1", "SRCAP", "SREK1", "SRI", "SRM", "SRP54", "SRP68", "SRP72", "SRP9", "SRPK1", "SRPRA", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF2", "SRSF3", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSRP1", "STAG2", "STAM", "STAMBP", "STARD3", "STARD3NL", "STARD7", "STAT1", "STAT3", "STAU1", "STAU2", "STIP1", "STOM", "STOML2", "STRBP", "STUB1", "STX18", "STX4", "STX5", "STX7", "STX8", "STXBP4", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGP2", "SUGT1", "SUN1", "SUPT16H", "SUPT5H", "SUPT6H", "SUPV3L1", "SURF6", "SUZ12", "SYAP1", "SYMPK", "SYNCRIP", "SYNE2", "SYNGR2", "TACC3", "TAF15", "TAF6L", "TAGLN2", "TARDBP", "TARS", "TARS2", "TBC1D13", "TBC1D15", "TBC1D4", "TBC1D9B", "TBCB", "TBCD", "TBCE", "TBL3", "TBRG4", "TCEA1", "TCERG1", "TCOF1", "TDP2", "TDRKH", "TECR", "TELO2", "TERF2IP", "TEX10", "TFAM", "TFCP2", "TFG", "TFRC", "THADA", "THOC1", "THOC2", "THOC3", "THOP1", "THUMPD1", "THUMPD3", "THYN1", "TIAL1", "TIMM13", "TIMM44", "TIMM50", "TIMM8A", "TIMM8B", "TJP1", "TKT", "TLCD1", "TLN1", "TMED10", "TMED2", "TMED5", "TMED7", "TMED9", "TMEM205", "TMEM97", "TMPO", "TMPO", "TMPPE", "TMTC3", "TMX1", "TMX2", "TMX4", "TNPO1", "TNPO3", "TOE1", "TOLLIP", "TOM1", "TOP1", "TOP2A", "TOP2B", "TOX4", "TP53", "TP53BP2", "TPP1", "TPP2", "TPR", "TPT1", "TPX2", "TRA2A", "TRA2B", "TRAF2", "TRAM1", "TRAP1", "TRAPPC11", "TRIM21", "TRIM25", "TRIM28", "TRIM33", "TRIO", "TRIP12", "TRIP13", "TRMT10C", "TRMT1L", "TROVE2", "TRUB1", "TSFM", "TSG101", "TSR1", "TTC4", "TTK", "TUBB", "TUBB2A", "TUBB2B", "TUBB4A", "TUBB4B", "TUBB6", "TUBGCP2", "TUBGCP3", "TUFM", "TWF1", "TWF2", "TXNDC12", "TXNDC17", "TXNDC5", "TXNDC9", "TXNL1", "TXNRD1", "TYMS", "U2AF2", "U2SURP", "UBA1", "UBA2", "UBA3", "UBA6", "UBAP2L", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2O", "UBE2Q1", "UBE2S", "UBE3C", "UBE4A", "UBR2", "UBR4", "UBR5", "UBR7", "UBTF", "UBXN7", "UCHL5", "UCK2", "UGDH", "UGGT1", "UHRF1", "UMPS", "UNC119B", "UNC45A", "UPF1", "UQCRC1", "UQCRC2", "URB1", "UROD", "USO1", "USP10", "USP11", "USP14", "USP24", "USP28", "USP34", "USP39", "USP47", "USP48", "USP5", "USP7", "USP8", "USP9X", "UTP15", "UTP20", "UTRN", "VAMP7", "VAPA", "VAPB", "VARS1", "VAT1", "VCP", "VIM", "VKORC1L1", "VPS16", "VPS18", "VPS29", "VPS4A", "VPS4B", "VPS51", "VPS53", "VRK1", "WAPL", "WARS", "WDHD1", "WDR12", "WDR18", "WDR3", "WDR36", "WDR43", "WFS1", "WIZ", "XPNPEP1", "XPNPEP3", "XPO1", "XPO5", "XPO7", "XPOT", "XRCC5", "XRCC6", "XRN2", "YARS", "YBX1", "YKT6", "YME1L1", "YRDC", "YTHDC1", "YTHDC2", "YTHDF2", "YTHDF3", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2", "ZC3H11A", "ZC3H14", "ZC3H15", "ZC3H18", "ZC3H4", "ZC3HAV1", "ZCCHC11", "ZCCHC3", "ZCCHC8", "ZFR", "ZFYVE16", "ZMPSTE24", "ZMYM4", "ZNF280C", "ZNF318", "ZNF326", "ZNF638", "ZPR1", "ZYX"], "leading_proteins": ["ABCB1", "ADD3", "ANKLE2", "APP", "AQR", "ARIH2", "ATAD3A", "ATP13A1", "ATP1A1", "ATP2A2", "ATP7B", "BSG", "CACYBP", "CALU", "CBX1", "CBX5", "CERS2", "CIAPIN1", "CIRBP", "CLCN3", "CLCN7", "CNNM4", "CNOT4", "COPG1", "CPSF3", "CTPS1", "CTSB", "CXADR", "CYB5B", "DNAJA3", "DNM1L", "DR1", "DSC3", "ECI2", "EHD1", "EHD4", "ELMOD2", "ELOA", "EPHA7", "EWSR1", "FAM49B", "FCGRT", "FKBP10", "FKBP14", "FKBP1A", "FKBP7", "FLOT1", "FLOT2", "FMR1", "FUBP1", "FUBP3", "FUCA2", "FUS", "FXR1", "FXR2", "GALNT1", "GALNT2", "GINS3", "GPAM", "GRWD1", "HADH", "HDGF", "HDGFL2", "HEXA", "HK2", "HLA-A", "HLA-B", "HLA-C", "HNRNPA0", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPL", "HNRNPLL", "HNRNPR", "HSD17B4", "HSDL2", "IDH2", "IGF2R", "ILVBL", "IMP4", "INTS11", "IPO7", "KCTD5", "KHDRBS1", "KHSRP", "KMT2A", "LBR", "LGALS3BP", "LMAN1", "LNPEP", "LTA4H", "MANBA", "MOSPD2", "MOV10", "MPP6", "MRPS5", "NAA40", "NDUFS1", "NENF", "NLE1", "NLN", "NONO", "NPC2", "NPEPPS", "NSUN5", "NUCB1", "NUCB2", "NUP133", "NUP50", "OCLN", "OLA1", "P3H1", "PABPC4", "PARN", "PGRMC2", "PITRM1", "PLD3", "PMPCA", "POLE4", "POR", "PPAN", "PPP1CB", "PSME2", "PSME3", "PTBP2", "PUF60", "PWP2", "PYCR1", "RAD23A", "RANBP1", "RANBP3", "RAVER1", "RBBP4", "RBM12B", "RBM14", "RBM4", "RBM5", "RBMX", "RCN2", "REXO4", "RPF2", "RTN3", "SEC16A", "SEPT2", "SEPT7", "SFPQ", "SHMT1", "SKP1", "SLC12A2", "SLC16A1", "SMN1*", "SMYD3", "SPNS1", "SPPL2A", "SPTLC1", "STARD7", "STOM", "STX7", "STX8", "SYNCRIP", "TAF15", "TCEA1", "TIAL1", "TIMM44", "TMPO", "TRAM1", "TRUB1", "VAPA", "VPS51", "WDR12", "WDR43", "YTHDC2", "ZCCHC3", "ZNF326"]} \ No newline at end of file diff --git a/interpro_family/advanced/idx2term.json b/interpro_family/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..fd09a3b6b2b39745d9faf596deccb20a9bd32593 --- /dev/null +++ b/interpro_family/advanced/idx2term.json @@ -0,0 +1 @@ +{"0": "Proteasome B-type subunit [IPR023333]"} \ No newline at end of file diff --git a/interpro_family/advanced/plot_0.png b/interpro_family/advanced/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..c643ba73f7fc79062b83acb73ff7f19b85625349 --- /dev/null +++ b/interpro_family/advanced/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:dd87548448136a49f188c472040546a5266b5f4157925a7d9d24f861da266df2 +size 179149 diff --git a/interpro_family/basic/idx2term.json b/interpro_family/basic/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..8e1d3118439cbe3ca8c29da0bec8a744affc7143 --- /dev/null +++ b/interpro_family/basic/idx2term.json @@ -0,0 +1 @@ +{"0": "Proteasome B-type subunit [IPR023333]", "1": "Proteasome, subunit alpha/beta [IPR001353]", "2": "Mitochondrial carrier protein [IPR002067]", "3": "Short-chain dehydrogenase/reductase SDR [IPR002347]", "4": "Small GTPase [IPR001806]"} \ No newline at end of file diff --git a/interpro_family/basic/plot_0.png b/interpro_family/basic/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..8c3d34295d0eb8bc7a1ee0bd0196ff9365748538 --- /dev/null +++ b/interpro_family/basic/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:423c8dce2a6a1db6d2ea08845457fa1710e57682c09f7d35254a8c7fcb490e8c +size 136407 diff --git a/interpro_family/basic/plot_1.png b/interpro_family/basic/plot_1.png new file mode 100644 index 0000000000000000000000000000000000000000..d73a3b8f73e74b251163fdf9f14306770bd9651e --- /dev/null +++ b/interpro_family/basic/plot_1.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:3d438ea79b43e4d12cbe7c87c9e6ef20c330d2eae1badef50ccc88f72e8a8a70 +size 136756 diff --git a/interpro_family/basic/plot_2.png b/interpro_family/basic/plot_2.png new file mode 100644 index 0000000000000000000000000000000000000000..966a842e7142ddd442e57b124a89b743268f462b --- /dev/null +++ b/interpro_family/basic/plot_2.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:e1ef786a1db46a4a26299050d76920eb6aedf784c0f12c29b77de588b2c5d1f0 +size 133024 diff --git a/interpro_family/basic/plot_3.png b/interpro_family/basic/plot_3.png new file mode 100644 index 0000000000000000000000000000000000000000..82968dea1d26a4f1bf0f4ea4cb46b483d545618e --- /dev/null +++ b/interpro_family/basic/plot_3.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:addf630103d3738e109d0c82cc40df4cdea69c840bf679e269083213271f0b2f +size 151160 diff --git a/interpro_family/basic/plot_4.png b/interpro_family/basic/plot_4.png new file mode 100644 index 0000000000000000000000000000000000000000..3a94594631e68b8bee751b37005b1fd930c95561 --- /dev/null +++ b/interpro_family/basic/plot_4.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:879b365ccba62768e7755dd8d58f9cbfa7fe22b2a292d68bdb6773cf121c7726 +size 146620 diff --git a/interpro_family/consensus.joblib b/interpro_family/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..c3b5167248d69d49dc4cd61ffaea3ac2dd4ff6ad --- /dev/null +++ b/interpro_family/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:d11c0b1b57dcd56137bbd6714e8a81ce3a00b76ab2775e5ad7b4d6f938f5e79e +size 127243 diff --git a/interpro_family/df_merge.tsv b/interpro_family/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..8607c7bc43bba55d56d8a34412a525dad5e3700d --- /dev/null +++ b/interpro_family/df_merge.tsv @@ -0,0 +1,2 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Proteasome B-type subunit [IPR023333] 6 7 2.1343903070752974 0.0328108443682415 3.699029126213592 6.970873786407767 1.6670727234653664 0.1509307531330224 1.4503762582219135 0.1681602725795027 0.9611878160538336 0.233503072382129 0.0002361262018994 1.0 0.0031504918831051 9.327097249989188e-07 1.9890121517705644e-08 diff --git a/interpro_family/metrics.json b/interpro_family/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..bed2d11840c57909d0dd0cf7d2ac805530067fbf --- /dev/null +++ b/interpro_family/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2644, + "annotations_size": 2106, + "title": "Average number of proteins per term", + "value": 1.2730294396961064 +} \ No newline at end of file diff --git a/interpro_family/paths.json b/interpro_family/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..e2d315f6eaef9a384ba2b82e127fe4a52fe235dc --- /dev/null +++ b/interpro_family/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/interpro_family/fragment/C197/C197_val_log2fc"} \ No newline at end of file diff --git a/interpro_family/result.tsv b/interpro_family/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..9f57d294e59ade0ba9ba5f07268bdea1a3912d40 --- /dev/null +++ b/interpro_family/result.tsv @@ -0,0 +1,105 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Proteasome B-type subunit [IPR023333] 0.8320060675009419 2.1343903070752974 0.0328108443682415 1.0 0.5225468288566709 7 P20618,Q99436,P49720,P49721,P28072,P28070 6 +Peptidase S10, serine carboxypeptidase [IPR001563] 0.96895115486558 2.025622031583909 0.0428035320636541 1.0 0.5225468288566709 3 P10619,Q9HB40 2 +Eukaryotic porin/Tom40 [IPR027246] 0.8727622101304762 1.9643597444788607 0.0494883877285947 1.0 0.5225468288566709 4 P45880,P21796 2 +Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase [IPR001930] 0.8310580844152108 1.9493511842688092 0.0512534999439111 1.0 0.5225468288566709 5 P09960,Q9UIQ6,P55786 3 +TAF15/EWS/TLS family [IPR034870] 0.9295721317682704 1.870152220151733 0.0614626825688171 1.0 0.5225468288566709 3 P35637,Q01844 2 +Porin, eukaryotic type [IPR001925] 0.9166982203710768 1.8189717222202368 0.068915744357521 1.0 0.5225468288566709 3 P45880,P21796 2 +P-type ATPase [IPR001757] 0.7790829859795405 1.7320628259576831 0.0832623770267044 1.0 0.5225468288566709 5 P05023,P35670,Q9HD20,P16615 4 +Aminopeptidase N-type [IPR034016] 0.8924649753881135 1.722217686459327 0.0850300921202895 1.0 0.5225468288566709 3 P55786,Q9UIQ6 2 +Tetraspanin/Peripherin [IPR018499] 0.992429977289932 1.7061448728448674 0.0879811096363463 1.0 0.5225468288566709 2 O43657 1 +Tetraspanin, animals [IPR000301] 0.992429977289932 1.7061448728448674 0.0879811096363463 1.0 0.5225468288566709 2 O43657 1 +Mitochondrial inner membrane translocase complex, subunit Tim17 [IPR005678] 0.98561695685087 1.6782892593897265 0.093290643792935 1.0 0.5225468288566709 2 Q99595 1 +Fragile X mental retardation syndrome-related protein [IPR040148] 0.88034835289663 1.6736605745703517 0.0941973263089877 1.0 0.5225468288566709 3 Q06787,P51116 2 +Syntaxin [IPR045242] 0.7967256820238279 1.651945429908154 0.0985456757682925 1.0 0.5225468288566709 4 O15400,Q9UNK0 2 +Transmembrane protein GPR107/GPR108-like [IPR009637] 0.9772899318697954 1.6442218217957374 0.1001303909911701 1.0 0.5225468288566709 2 Q5VW38 1 +Amyloidogenic glycoprotein [IPR008155] 0.9746404239212711 1.6333779899592 0.1023895232075535 1.0 0.5227840006236038 2 P05067 1 +CD36 family [IPR002159] 0.9738834216502644 1.6302794297329797 0.1030424530488178 1.0 0.5227840006236038 2 Q14108 1 +Alpha-L-fucosidase, metazoa-type [IPR016286] 0.9682059046177132 1.60703621727939 0.108046423516257 1.0 0.5239182904244842 2 Q9BTY2 1 +Glycoside hydrolase, family 29 [IPR000933] 0.9682059046177132 1.60703621727939 0.108046423516257 1.0 0.5239182904244842 2 Q9BTY2 1 +V-type ATPase, V0 complex, 116kDa subunit family [IPR002490] 0.9621498864496588 1.5822371967810989 0.1135954317961194 1.0 0.5262069393659932 2 Q93050 1 +ATPase, V0 complex, subunit 116kDa, eukaryotic [IPR026028] 0.9621498864496588 1.5822371967810989 0.1135954317961194 1.0 0.5262069393659932 2 Q93050 1 +Beta-hexosaminidase [IPR025705] 0.9572293716881142 1.562084850936088 0.1182680011726575 1.0 0.5315484002098012 2 P06865 1 +Mpv17/PMP22 [IPR007248] 0.956850870552611 1.5605345961615138 0.1186336009870849 1.0 0.5315484002098012 2 Q567V2 1 +Nucleobindin [IPR040250] 0.9542013626040866 1.5496826373226036 0.1212177074966089 1.0 0.5330826515365739 2 P80303 1 +Proteasome, subunit alpha/beta [IPR001353] 0.5649998117716991 1.5363939075137367 0.1244418000968894 1.0 0.535939531705622 14 P28074,P20618,Q99436,P49720,P49721,P28072,P28070 7 +Solute carrier family 35 member SLC35F1/F2/F6 [IPR009262] 0.94890234670704 1.5279784868176134 0.1265178794163759 1.0 0.5363905354803508 2 Q5T1Q4 1 +Palmitoyl protein thioesterase [IPR002472] 0.9477668433005284 1.5233276897004793 0.1276767429343097 1.0 0.5377744412393127 2 P50897 1 +Isocitrate dehydrogenase NADP-dependent [IPR004790] 0.9447388342165024 1.5109259674550393 0.1308073139958663 1.0 0.5421605031754088 2 P48735 1 +Peptidase T1A, proteasome beta-subunit [IPR000243] 0.8307459295721323 1.473977419845619 0.1404876708865474 1.0 0.5503218106821568 3 P28072,Q99436 2 +Ergosterol biosynthesis ERG4/ERG24 [IPR001171] 0.9333838001513992 1.464430138431451 0.1430764583892956 1.0 0.5521519310192156 2 Q9UBM7 1 +Major facilitator superfamily [IPR011701] 0.7496212121212162 1.4552704518345427 0.1455944034666385 1.0 0.5521519310192156 4 Q96ES6,Q9H2V7,P53985 3 +Small GTPase, Ras-type [IPR020849] 0.7291595948401648 1.3693836376154311 0.1708793861955508 1.0 0.5735913908603113 4 P11233 1 +Flotillin family [IPR027705] 0.9042392127176382 1.3452872418055213 0.1785324920201692 1.0 0.5767761626881754 2 O75955 1 +Cytochrome P450 [IPR001128] 0.8962906888720638 1.3128794744972878 0.1892235642774928 1.0 0.5857214117421246 2 Q16850 1 +Mitochondrial carrier UCP-like [IPR002030] 0.8959121877365609 1.3113374963929196 0.1897437655163845 1.0 0.5857214117421246 2 Q9H2D1 1 +Nonaspanin (TM9SF) [IPR004240] 0.8917486752460242 1.2943839477494683 0.1955328325271645 1.0 0.5911777308248379 2 Q9HD45 1 +Membrane bound O-acyl transferase, MBOAT [IPR004299] 0.8830431491294464 1.2589889436776096 0.2080343254099381 1.0 0.6063079172208518 2 Q96N66 1 +HnRNP R/Q splicing factor [IPR006535] 0.8743376230128685 1.223676827138079 0.2210741646842797 1.0 0.6191252537567729 2 O60506 1 +Cleft lip and palate transmembrane 1 [IPR008429] 0.8713096139288411 1.2114162744810784 0.2257359051772085 1.0 0.6228587885794591 2 O96005 1 +Cleft lip and palate transmembrane protein 1-like protein [IPR030434] 0.8713096139288411 1.2114162744810784 0.2257359051772085 1.0 0.6228587885794591 2 O96005 1 +TB2/DP1/HVA22-related protein [IPR004345] 0.8679031037093111 1.1976378664242306 0.231058027812788 1.0 0.6257139722033117 2 Q9H6H4 1 +Membrane-associated, eicosanoid/glutathione metabolism (MAPEG) protein [IPR001129] 0.8667676003028011 1.1930486697118523 0.2328503126656342 1.0 0.6257139722033117 2 Q99735 1 +ADP/ATP carrier protein, eukaryotic type [IPR002113] 0.7535024611889469 1.1627547169700927 0.2449290344562738 1.0 0.6336047309470909 3 P12235,P12236 2 +Mitochondrial carrier protein [IPR002067] 0.5214402492829947 1.1576035511813445 0.247025859410684 1.0 0.6352093527703303 11 P12235,Q9HC21,P12236,P05141,Q86VD7,Q6NUK1,Q96H78 7 +Chaperone DnaJ [IPR012724] 0.7364192222869907 1.0945001923560076 0.2737356630580589 1.0 0.6506628740409393 3 Q96EY1 1 +Tricarboxylate/iron carrier [IPR004686] 0.7356712574703876 1.0915210009910017 0.275043696142718 1.0 0.6511974702174713 3 Q6P4A7 1 +HnRNP-L/PTB [IPR006536] 0.6628787878787937 1.0911715330377922 0.2751974114404318 1.0 0.6511974702174713 4 Q8WVV9,Q9UKA9,P14866 3 +Chloride channel, voltage gated [IPR001807] 0.8398940196820549 1.0850565816207454 0.2778965958513963 1.0 0.6529376295402888 2 P51790 1 +SCAMP [IPR007273] 0.833838001514002 1.060912693223683 0.2887295801896798 1.0 0.6634343592491668 2 O15127 1 +A-kinase anchoring protein 95 (AKAP95) [IPR007071] 0.7270845438820368 1.0573840927213007 0.2903363283904268 1.0 0.6634343592491668 3 Q5BKZ1 1 +Haem oxygenase-like [IPR016053] 0.8277819833459477 1.0368523369703433 0.2998046798528184 1.0 0.6722222481799995 2 P30519 1 +Haem oxygenase [IPR002051] 0.8277819833459477 1.0368523369703433 0.2998046798528184 1.0 0.6722222481799995 2 P30519 1 +Glycerol-3-phosphate O-acyltransferase/Dihydroxyacetone phosphate acyltransferase [IPR022284] 0.8035579106737301 0.9415782221865548 0.3464086238279764 1.0 0.7274084857364385 2 Q9HCL2 1 +Pyridoxal phosphate-dependent decarboxylase [IPR002129] 0.7861468584405733 0.8742421129337704 0.381986416358032 1.0 0.7676177412690987 2 O95470 1 +SLC12A transporter family [IPR004842] 0.7831188493565462 0.8626450464359732 0.3883326551573787 1.0 0.7715784846630152 2 P55011 1 +MICOS complex subunit MIC26/MIC27 [IPR019166] 0.7770628311884904 0.8395609435505184 0.4011546054303214 1.0 0.783702782037344 2 Q9BUR5 1 +MICOS complex subunit MIC26/MIC27, animal [IPR033182] 0.7770628311884904 0.8395609435505184 0.4011546054303214 1.0 0.783702782037344 2 Q9BUR5 1 +Prenylated rab acceptor PRA1 [IPR004895] 0.7698713096139247 0.8123492292535561 0.4165912699528205 1.0 0.7961354033762613 2 O60831 1 +Prenyltransferase subunit beta [IPR045089] 0.756623769871307 0.7628412480825977 0.4455580781931085 1.0 0.8185897921230018 2 P49356 1 +Graves disease carrier protein [IPR002167] 0.7509462528387558 0.7418888728176815 0.458154668103786 1.0 0.8296016809198964 2 Q6NUK1 1 +Short-chain dehydrogenase/reductase SDR [IPR002347] 0.4110517116639257 0.6666824804421895 0.5049749717890024 1.0 0.8582058561068993 16 Q8NBQ5,P35270,Q06136,Q96LJ7,Q3SXM5 5 +Peptidase M3A/M3B [IPR045090] 0.6145431023771605 0.6300523484630068 0.5286603349790446 1.0 0.8727705407751223 3 Q9BYT8 1 +H/ACA ribonucleoprotein complex, subunit Gar1/Naf1 [IPR007504] 0.7168811506434483 0.6200568466726483 0.5352203615717994 1.0 0.8740600562434632 2 Q96HR8 1 +CTP synthase [IPR004468] 0.7009841029523046 0.5658329637822342 0.5715073356616662 1.0 0.8943197962099964 2 P17812 1 +Calponin/LIMCH1 [IPR001997] 0.698713096139284 0.5582413438159471 0.5766795925377117 1.0 0.8963294218295923 2 Q99439 1 +Heterogeneous nuclear ribonucleoprotein C [IPR017347] 0.6930355791067329 0.5394406907778106 0.589582810442399 1.0 0.9036836963549436 2 P07910 1 +S-phase kinase-associated protein 1-like [IPR001232] 0.6828160484481407 0.5062673640725357 0.612668970434346 1.0 0.9143474047690212 2 P63208 1 +Serine hydroxymethyltransferase [IPR001085] 0.6797880393641134 0.4966097397257876 0.6194642834950328 1.0 0.9168519489394148 2 P34896 1 +CPSF6/7 family [IPR034772] 0.6752460257380722 0.4822756385405123 0.6296101508029994 1.0 0.9221676236315864 2 Q16630 1 +Profilin1/2/3, vertebrate [IPR005454] 0.6616199848599492 0.4404156182303438 0.6596361151342682 1.0 0.9350899717592032 2 P35080 1 +Profilin [IPR005455] 0.6616199848599492 0.4404156182303438 0.6596361151342682 1.0 0.9350899717592032 2 P35080 1 +ATPase family AAA domain-containing protein 3 [IPR039188] 0.6551854655563911 0.4212712259258311 0.6735570390574908 1.0 0.9385538114505666 2 Q9NVI7 1 +Tumour protein D52 [IPR007327] 0.6442089326267919 0.389585095879151 0.6968433748223333 1.0 0.949551015522276 2 P55327 1 +Prefoldin alpha-like [IPR004127] 0.6392884178652477 0.3757929822789022 0.7070708053944836 1.0 0.9514193226976524 2 P61758 1 +RNA (C5-cytosine) methyltransferase [IPR023267] 0.5347018581451038 0.3722410803092374 0.7097133625067416 1.0 0.9514193226976524 3 Q96P11 1 +Desmosomal cadherin [IPR009122] 0.5231767518201947 0.3400572383522252 0.7338134236140064 1.0 0.9604792232014278 3 Q14574 1 +DNA2/NAM7-like helicase [IPR045055] 0.4515847427479421 0.2988995163619052 0.7650167161347798 1.0 0.963939052619487 4 Q9HCE1,O60306 2 +Vesicle-associated membrane-protein-associated protein [IPR016763] 0.600681302043899 0.277107538581159 0.7816975334608385 1.0 0.963939052619487 2 Q9P0L0 1 +Sec1-like protein [IPR001619] 0.4846648996592022 0.2439752178198262 0.8072500133576326 1.0 0.963939052619487 3 Q8WVM8,O00186 2 +Exosome complex RNA-binding protein 1/RRP40/RRP4 [IPR026699] 0.5794852384557099 0.2306161376408749 0.8176130294966779 1.0 0.963939052619487 2 Q9NQT5 1 +Polyadenylate binding protein, human types 1, 2, 3, 4 [IPR006515] 0.5772142316426904 0.225973434355888 0.8212220822492642 1.0 0.963939052619487 2 Q13310 1 +Pyridine nucleotide-disulphide oxidoreductase, class I [IPR001100] 0.57532172596517 0.2221551467465438 0.8241931093540036 1.0 0.963939052619487 2 P00390 1 +UV excision repair protein Rad23 [IPR004806] 0.5730507191521507 0.2176340860467473 0.8277142241755022 1.0 0.963939052619487 2 P54725 1 +Ribosomal protein L1/ribosomal biogenesis protein [IPR028364] 0.4589170768648138 0.1904171906082035 0.8489822279533978 1.0 0.963939052619487 3 O76021,Q9BYD6 2 +Translin family [IPR002848] 0.5514761544284548 0.1780120860473755 0.8587134840448181 1.0 0.963939052619487 2 Q99598 1 +Pyrroline-5-carboxylate reductase [IPR000304] 0.5423921271763729 0.1631306649933326 0.870415556010476 1.0 0.963939052619487 2 P32322 1 +AP-1/2/4 complex subunit beta [IPR016342] 0.5219530658591883 0.1334925248557986 0.8938038756634585 1.0 0.963939052619487 2 Q10567 1 +Phosphatidylethanolamine-binding protein [IPR008914] 0.518168054504154 0.1285764875962499 0.8976927720327159 1.0 0.963939052619487 2 Q96DV4 1 +Phosphatidylethanolamine-binding protein, eukaryotic [IPR035810] 0.518168054504154 0.1285764875962499 0.8976927720327159 1.0 0.963939052619487 2 Q96DV4 1 +Small GTPase superfamily, ARF/SAR type [IPR006689] 0.3780958465542748 0.1283337830721779 0.8978848311135164 1.0 0.963939052619487 6 Q9NR31,P40616,Q8N8L6 3 +Proteasome activator PA28 [IPR009077] 0.4184021204089265 0.1243687497997235 0.9010233152619408 1.0 0.963939052619487 3 P61289,Q9UL46 2 +Ran binding protein RanBP1-like [IPR045255] 0.3503787878787998 0.0794288572128987 0.9366915164084846 1.0 0.975114876629968 4 Q9UKX7,Q9H6Z4,P43487 3 +Ribosomal protein L37/S30 [IPR010793] 0.4678274034822002 0.0788556483974397 0.9371474407877756 1.0 0.975114876629968 2 Q9NP92 1 +Small GTPase superfamily, ARF type [IPR024156] 0.4613928841786483 0.074400968983278 0.9406913378049132 1.0 0.9765570754099738 2 P40616 1 +E3 ubiquitin ligase RBR family [IPR031127] 0.450416351249046 0.0676585275774773 0.946057463820825 1.0 0.9781035929340488 2 O95376 1 +NSF attachment protein [IPR000744] 0.4462528387585085 0.065367628090601 0.9478812979769824 1.0 0.9781784557256415 2 Q99747 1 +Ribosomal protein L14P [IPR000218] 0.4454958364875061 0.0649661451761469 0.9482009555240378 1.0 0.9781784557256415 2 Q6P1L8 1 +Coatomer gamma subunit [IPR017106] 0.4390613171839398 0.0617340849574712 0.9507745958548852 1.0 0.9781784557256415 2 Q9Y678 1 +Ribosomal protein S9 [IPR000754] 0.4330052990158922 0.0589751132933608 0.9529719303163844 1.0 0.9785270040206268 2 P82933 1 +Septin [IPR016491] 0.3430518742900456 0.056093834305687 0.9552670557180438 1.0 0.9794330399181668 3 Q16181,Q15019 2 +Ribosomal protein S8e/ribosomal biogenesis NSA2 [IPR022309] 0.39969719909159 0.0479822041159497 0.9617304253277632 1.0 0.9794330399181668 2 O95478 1 +Filamin family [IPR044801] 0.3203332071185185 0.0464143007599558 0.962980038439078 1.0 0.9794330399181668 3 O75369,Q14315 2 +Ribosomal protein S5 [IPR000851] 0.369417108251315 0.0426025975062169 0.9660183248613908 1.0 0.9794330399181668 2 P82675 1 +Hexokinase [IPR001312] 0.3050719152157387 0.0386802528548032 0.9691453175646784 1.0 0.9794870871511772 2 P52789 1 +Small GTPase [IPR001806] 0.3031837449494196 0.0029250310409015 0.9976661662205676 1.0 1.0 25 P11233,P61225,P61019,P51149,Q969Q5 5 diff --git a/interpro_family/selections.json b/interpro_family/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..0bfc6ba0e037833c0b0c92d0be904cbc3bd45569 --- /dev/null +++ b/interpro_family/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase, eukaryotes [IPR027496]", "1-Cys peroxiredoxin [IPR045020]", "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [IPR028380]", "14-3-3 protein [IPR000308]", "14-3-3 theta [IPR042584]", "18S rRNA (guanine(1575)-N(7))-methyltransferase Bud23-like [IPR039769]", "2-amino-3-ketobutyrate coenzyme A ligase [IPR011282]", "2-deoxynucleoside 5-phosphate N-hydrolase 1, DNPH1 [IPR028607]", "2-oxoglutarate dehydrogenase E1 component [IPR011603]", "2-phosphoglycolate phosphatase, eukaryotic [IPR006349]", "26S Proteasome non-ATPase regulatory subunit 1 [IPR035266]", "26S Proteasome non-ATPase regulatory subunit 11 [IPR035295]", "26S Proteasome non-ATPase regulatory subunit 12 [IPR035297]", "26S Proteasome non-ATPase regulatory subunit 12/COP9 signalosome complex subunit 4 [IPR040134]", "26S Proteasome non-ATPase regulatory subunit 13 [IPR035298]", "26S Proteasome non-ATPase regulatory subunit 14 [IPR035299]", "26S Proteasome non-ATPase regulatory subunit 6 [IPR035268]", "26S Proteasome non-ATPase regulatory subunit 7/8 [IPR033858]", "26S Proteasome regulatory subunit 4 [IPR035244]", "26S Proteasome regulatory subunit 6A [IPR035254]", "26S Proteasome regulatory subunit 6B [IPR035256]", "26S Proteasome regulatory subunit 7 [IPR035245]", "26S proteasome non-ATPase regulatory subunit 10-like [IPR039334]", "26S proteasome non-ATPase regulatory subunit 3 [IPR035267]", "26S proteasome non-ATPase regulatory subunit Rpn12 [IPR006746]", "26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit [IPR016643]", "26S proteasome regulatory complex, non-ATPase subcomplex, Rpn2/Psmd1 subunit [IPR016642]", "26S proteasome regulatory subunit 10B [IPR035263]", "26S proteasome regulatory subunit P45-like [IPR005937]", "26S proteasome regulatory subunit Rpn7/COP9 signalosome complex subunit 1 [IPR019585]", "28S ribosomal protein S25, mitochondrial [IPR040049]", "28S ribosomal protein S27, mitochondrial [IPR019266]", "28kDa heat- and acid-stable phosphoprotein [IPR039876]", "3'-5' RNA helicase YTHDC2-like [IPR031083]", "3-hydroxyacyl-CoA dehydrogenase [IPR022694]", "3-hydroxyisobutyrate dehydrogenase [IPR011548]", "3-hydroxyisobutyrate dehydrogenase-related [IPR015815]", "3-ketodihydrosphingosine reductase KDSR-like [IPR045022]", "3-oxo-5-alpha-steroid 4-dehydrogenase/very-long-chain enoyl-CoA reductase [IPR039357]", "39S ribosomal protein L40, mitochondrial [IPR039145]", "39S ribosomal protein L46, mitochondrial [IPR040008]", "40S Ribosomal protein S10 [IPR037447]", "40S ribosomal protein S1/3, eukaryotes [IPR027500]", "40S ribosomal protein SA [IPR027504]", "4F2 cell-surface antigen heavy chain [IPR042280]", "5'-3' exoribonuclease [IPR027073]", "5'-3' exoribonuclease type 2 [IPR017151]", "5'-AMP-activated protein kinase subunit gamma-1 [IPR039166]", "5-lipoxygenase-activating protein [IPR001446]", "50S ribosomal protein L18Ae/60S ribosomal protein L20 and L18a [IPR028877]", "6-Phosphogluconolactonase [IPR039104]", "6-phosphogluconate dehydrogenase [IPR006183]", "6-phosphogluconate dehydrogenase, decarboxylating [IPR006113]", "60S acidic ribosomal protein P0 [IPR030670]", "60S ribosomal protein L18a/ L20, eukaryotes [IPR021138]", "60S ribosomal protein L19 [IPR039547]", "60S ribosomal protein L35 [IPR045059]", "60S ribosomal protein L6E [IPR000915]", "60kDa SS-A/Ro ribonucleoprotein [IPR040322]", "A-kinase anchor protein 12 [IPR028540]", "A-kinase anchor protein 13 [IPR028852]", "A-kinase anchor protein 17A [IPR034355]", "A-kinase anchoring protein 95 (AKAP95) [IPR007071]", "AAA ATPase, CDC48 family [IPR005938]", "ABI family [IPR028457]", "ADF/Cofilin [IPR017904]", "ADP-ribosylation factor 1-5 [IPR045872]", "ADP-ribosylation factor-like protein 10 [IPR042951]", "ADP-ribosylation factor-like protein 2 [IPR045873]", "ADP-ribosylation factor-like protein 2/3 [IPR044612]", "ADP-ribosylation factor-like protein 6-interacting protein 1 [IPR033301]", "ADP-ribosylation/Crystallin J1 [IPR005502]", "ADP-specific phosphofructokinase/glucokinase [IPR007666]", "ADP/ATP carrier protein, eukaryotic type [IPR002113]", "AH receptor-interacting protein [IPR031208]", "AIP/AIPL1 [IPR039663]", "AP complex subunit beta [IPR026739]", "AP endonuclease 1 [IPR004808]", "AP-1 complex subunit sigma [IPR044733]", "AP-1/2/4 complex subunit beta [IPR016342]", "AP-2 complex subunit sigma [IPR027156]", "AP-3 complex subunit beta [IPR026740]", "ARMET-like [IPR045333]", "AT-rich interactive domain-containing protein 3 [IPR045147]", "ATP synthase membrane subunit K [IPR009125]", "ATP synthase, F0 complex, subunit A [IPR000568]", "ATP synthase, F0 complex, subunit A, bacterial/mitochondria [IPR045083]", "ATP synthase, F0 complex, subunit B [IPR013837]", "ATP synthase, F0 complex, subunit B/MI25 [IPR008688]", "ATP synthase, F0 complex, subunit D, mitochondrial [IPR008689]", "ATP synthase, F0 complex, subunit E, mitochondrial [IPR008386]", "ATP synthase, F0 complex, subunit G, mitochondrial [IPR006808]", "ATP synthase, F1 complex, alpha subunit [IPR005294]", "ATP synthase, F1 complex, beta subunit [IPR005722]", "ATP synthase, F1 complex, gamma subunit [IPR000131]", "ATP-citrate synthase [IPR014608]", "ATP-dependent 6-phosphofructokinase [IPR022953]", "ATP-dependent 6-phosphofructokinase, eukaryotic-type [IPR009161]", "ATP-dependent 6-phosphofructokinase, vertebrate-type [IPR041914]", "ATP-dependent Clp protease proteolytic subunit [IPR001907]", "ATP-dependent RNA helicase DHX29 [IPR034730]", "ATP-dependent RNA helicase Ski2-like [IPR016438]", "ATP-dependent helicase Rad3/Chl1-like [IPR013020]", "ATP11 [IPR010591]", "ATP:guanido phosphotransferase [IPR000749]", "ATPase family AAA domain-containing protein 3 [IPR039188]", "ATPase, OSCP/delta subunit [IPR000711]", "ATPase, V0 complex, c/d subunit [IPR002843]", "ATPase, V0 complex, subunit 116kDa, eukaryotic [IPR026028]", "ATPase, V0 complex, subunit d [IPR016727]", "ATPase, V1 complex, subunit A [IPR005725]", "ATPase, V1 complex, subunit B [IPR005723]", "ATPase, V1 complex, subunit C [IPR004907]", "ATPase, V1 complex, subunit D [IPR002699]", "ATPase, V1 complex, subunit H [IPR004908]", "ATPase, vacuolar ER assembly factor, Vma12 [IPR021013]", "Abl interactor 1 [IPR028456]", "Acid ceramidase-like [IPR016699]", "Acidic leucine-rich nuclear phosphoprotein 32 [IPR045081]", "Acireductone dioxygenase ARD family [IPR004313]", "Aconitase, mitochondrial-like [IPR006248]", "Actin family [IPR004000]", "Actin-related protein 2/3 complex subunit 1 [IPR017383]", "Actin-related protein 2/3 complex subunit 1A [IPR030140]", "Actin-related protein 2/3 complex subunit 2 [IPR007188]", "Actin-related protein 2/3 complex subunit 3 [IPR007204]", "Actin-related protein 2/3 complex subunit 4 [IPR008384]", "Actin-related protein 3 [IPR015623]", "Activator of 90kDa heat shock protein ATPase-like [IPR039981]", "Activator of Hsp90 ATPase homologue 1-like [IPR013538]", "Activity-dependent neuroprotector homeobox protein [IPR038861]", "Acyl-CoA desaturase [IPR015876]", "Acyl-CoA oxidase [IPR012258]", "Acyl-coenzyme A thioesterase 13 [IPR039298]", "Acylneuraminate cytidylyltransferase [IPR003329]", "Acyltransferase ChoActase/COT/CPT [IPR000542]", "Adaptor protein Cbl [IPR024162]", "Adaptor protein complex AP-1, gamma subunit [IPR017107]", "Adaptor protein complex AP-2, alpha subunit [IPR017104]", "Adaptor protein complex AP-3, delta subunit [IPR017105]", "Adaptor protein complex, sigma subunit [IPR016635]", "Adenine phosphoribosyl transferase [IPR005764]", "Adenosine kinase [IPR001805]", "Adenosylhomocysteinase-like [IPR000043]", "Adenylate cyclase-associated CAP [IPR001837]", "Adenylate kinase 2 [IPR028587]", "Adenylate kinase 3/4, mitochondrial [IPR028586]", "Adenylate kinase isoenzyme 1 [IPR028582]", "Adenylate kinase subfamily [IPR006259]", "Adenylate kinase, isozyme 1/5 [IPR006267]", "Adenylate kinase/UMP-CMP kinase [IPR000850]", "Adenylosuccinate lyase [IPR004769]", "Adenylosuccinate synthetase [IPR001114]", "Adenylosuccinate synthetase isozyme 2, chordates [IPR027529]", "Adenylyl cyclase-associated protein CAP1 [IPR028415]", "Adenylyl-sulfate kinase [IPR002891]", "AdoMet-dependent rRNA methyltransferase Spb1-like [IPR028589]", "Aladin [IPR045139]", "Alanine-tRNA ligase, class IIc [IPR002318]", "Alanine-tRNA ligase, eukaryota/bacteria [IPR023033]", "Alcohol dehydrogenase class III [IPR014183]", "Aldehyde dehydrogenase NAD(P)-dependent [IPR012394]", "Aldehyde dehydrogenase [IPR011408]", "Aldehyde dehydrogenase family 7 member A1-like [IPR044638]", "Aldo-keto reductase [IPR020471]", "Aldo-keto reductase family 1 member A1 [IPR044481]", "Aldose 1-/Glucose-6-phosphate 1-epimerase [IPR008183]", "Aldose 1-epimerase [IPR015443]", "Alkyldihydroxyacetonephosphate synthase [IPR025650]", "Alpha E-catenin/Alpha T-catenin [IPR030047]", "Alpha crystallin/Small heat shock protein, animal type [IPR001436]", "Alpha-D-phosphohexomutase superfamily [IPR005841]", "Alpha-L-fucosidase, metazoa-type [IPR016286]", "Alpha-N-acetylglucosaminidase [IPR007781]", "Alpha-N-methyltransferase NTM1 [IPR008576]", "Alpha-adducin [IPR027766]", "Alpha-catenin [IPR001033]", "Alpha-catulin 1 [IPR030045]", "Alpha-internexin [IPR027703]", "Alpha-ketoglutarate-dependent dioxygenase FTO [IPR032868]", "Amidophosphoribosyltransferase [IPR005854]", "Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 [IPR042360]", "Aminoacyl-tRNA synthetase, class Ic [IPR002305]", "Aminopeptidase N-type [IPR034016]", "Aminopeptidase, leukotriene A4 hydrolase-like [IPR034015]", "Aminotransferase class-III [IPR005814]", "AmpG-like permease/Acetyl-coenzyme A transporter 1 [IPR004752]", "Amyloid-beta precursor protein [IPR028866]", "Amyloidogenic glycoprotein [IPR008155]", "Anamorsin [IPR007785]", "Anaphase-promoting complex subunit 1 [IPR024990]", "Anaphase-promoting complex subunit 5 [IPR037679]", "Anaphase-promoting complex subunit APC10/Doc1 [IPR016901]", "Ancient conserved domain protein family [IPR045095]", "Angiomotin [IPR009114]", "Ankycorbin [IPR042420]", "Ankyrin repeat and LEM domain-containing protein 2 [IPR035007]", "Annexin A1 [IPR002388]", "Annexin A11 [IPR008157]", "Annexin A2 [IPR002389]", "Annexin A6 [IPR002393]", "Annexin [IPR001464]", "Anoctamin [IPR007632]", "Anoctamin-10 [IPR031291]", "Antifreeze, type III [IPR006013]", "Apolipoprotein L [IPR008405]", "Apoptosis inhibitory 5 [IPR008383]", "Apoptosis regulator, Mcl-1 [IPR013281]", "Arfaptin family [IPR030798]", "Arfaptin-1 [IPR030793]", "Arginine-tRNA ligase [IPR001278]", "Armadillo repeat-containing protein 6 [IPR040104]", "Arsenical pump ATPase, ArsA/GET3 [IPR016300]", "Arsenical pump ATPase, ArsA/GET3, eukaryotic [IPR027542]", "Arv1 protein [IPR007290]", "Arylesterase [IPR002640]", "Asparaginase-like 1, metazoa [IPR033844]", "Asparagine synthase, glutamine-hydrolyzing [IPR006426]", "Asparagine-tRNA ligase [IPR004522]", "Asparaginyl endopeptidase [IPR043577]", "Aspartate carbamoyltransferase [IPR002082]", "Aspartate-tRNA ligase, type 1 [IPR004524]", "Aspartate-tRNA synthetase, type 2 [IPR004523]", "Aspartate/ornithine carbamoyltransferase [IPR006130]", "Aspartate/other aminotransferase [IPR000796]", "Aspartyl/Asparaginyl-tRNA synthetase, class IIb [IPR002312]", "Aspartyl/asparaginyl beta-hydroxylase family [IPR039038]", "Associate of Myc 1 [IPR026060]", "Ataxin2-like [IPR045117]", "Atypical dual specificity phosphatase, subfamily A [IPR020405]", "Atypical kinase COQ8A [IPR034640]", "Aurora kinase [IPR030616]", "Autophagy protein Atg8 ubiquitin-like [IPR004241]", "B-cell receptor-associated protein 29/31 [IPR008417]", "BBP/SF1 family [IPR031150]", "BCAS3-like [IPR045142]", "BCP1 family [IPR025602]", "BRCA1-associated ATM activator 1 [IPR038904]", "Bacterial/eukaryotic lysine-tRNA ligase, class II [IPR034762]", "Baculoviral IAP repeat-containing protein 6 [IPR022103]", "Band 4.1 protein, chordates [IPR021187]", "Band 4.1-like protein 2 [IPR030546]", "Band 4.1-like protein 5 [IPR030694]", "Band-7 stomatin-like [IPR043202]", "Barrier- to-autointegration factor, BAF [IPR004122]", "Basigin [IPR044157]", "Basigin-like [IPR043204]", "Bax inhibitor 1-related [IPR006214]", "Bcl-2 family [IPR026298]", "Bcl-2-associated transcription factor 1 [IPR026668]", "Bcl2-like [IPR002475]", "Bet3 family [IPR016721]", "Beta tubulin [IPR002453]", "Beta-1,4-glucuronyltransferase 1 [IPR043189]", "Beta-N-acetylglucosaminidase [IPR011496]", "Beta-catenin [IPR013284]", "Beta-catenin-like protein 1 [IPR039678]", "Beta-galactosidase 1-like [IPR026283]", "Beta-hexosaminidase [IPR025705]", "Beta-thymosin [IPR001152]", "Bicarbonate transporter, eukaryotic [IPR003020]", "Bicaudal-D protein [IPR018477]", "Bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66 [IPR013109]", "Bifunctional purine biosynthesis protein PurH-like [IPR002695]", "Biliverdin reductase A [IPR017094]", "Biotin--acetyl-CoA-carboxylase ligase [IPR004408]", "BolA protein [IPR002634]", "BolA-like protein 2 [IPR045115]", "Bystin [IPR007955]", "C-5 cytosine methyltransferase [IPR001525]", "C-terminal binding protein [IPR043322]", "CAAX prenyl protease 1 [IPR027057]", "CCR4-NOT complex, subunit 3/ 5 [IPR012270]", "CCR4-NOT transcription complex subunit 1 [IPR040398]", "CCR4-NOT transcription complex subunit 4 [IPR039780]", "CCR4-NOT transcription complex subunit 7 [IPR039636]", "CCR4-NOT transcription complex subunit 7/8/Pop2 [IPR039637]", "CCR4-NOT transcription complex subunit 9 [IPR007216]", "CD2-associated protein [IPR028445]", "CD34/Podocalyxin [IPR013836]", "CD36 family [IPR002159]", "CD36/scavenger receptor class B member 1 [IPR005428]", "CDGSH iron-sulfur domain-containing protein 1/2 [IPR045131]", "CDK2-associated and cullin domain-containing protein 1 [IPR042652]", "CDK5 regulatory subunit-associated protein 3 [IPR008491]", "CDP-alcohol phosphatidyltransferase [IPR000462]", "CEBPZ/Mak21-like [IPR040155]", "CHORD domain containing protein [IPR039790]", "CLIP-associating protein 1 [IPR028399]", "CLU domain containing protein [IPR027523]", "COMM domain-containing protein 2 [IPR037354]", "COP9 Signalosome complex subunit 7A [IPR037757]", "COP9 signalosome complex subunit 1 [IPR033008]", "COP9 signalosome complex subunit 2 [IPR037750]", "COP9 signalosome complex subunit 3 [IPR037753]", "COP9 signalosome complex subunit 4 [IPR037754]", "COP9 signalosome complex subunit 5 [IPR037740]", "COP9 signalosome complex subunit 7B [IPR027530]", "COP9 signalosome subunit 6 [IPR033859]", "COP9 signalosome, subunit CSN8 [IPR033205]", "COPII coat assembly protein, Sec16 [IPR024880]", "CPSF6/7 family [IPR034772]", "CTP synthase [IPR004468]", "CWF11 family [IPR026300]", "CXXC motif containing zinc binding protein, eukaryotic [IPR008584]", "CYFIP-related Rac1 interactor [IPR039789]", "Calcium homeostasis endoplasmic reticulum protein [IPR039037]", "Calcium load-activated calcium channel [IPR008559]", "Calcium uptake protein 1/2/3 [IPR039800]", "Calcium-binding mitochondrial carrier protein Aralar2 [IPR029658]", "Calcium-binding protein CAB45 [IPR027240]", "Calcium-transporting ATPase type 2C member 1 [IPR030336]", "Caldesmon [IPR006017]", "Caldesmon/lymphocyte specific protein [IPR006018]", "Calpain small subunit 1 [IPR029642]", "Calpain-1 [IPR029643]", "Calpain-2 [IPR029539]", "Calpastatin [IPR026998]", "Calponin-2 [IPR029974]", "Calponin/LIMCH1 [IPR001997]", "Calreticulin [IPR009169]", "Calreticulin/calnexin [IPR001580]", "Calumenin [IPR027239]", "Cap-specific mRNA (nucleoside-2-O-)-methyltransferase 1 [IPR030376]", "Caprin [IPR028816]", "Carbamoyl-phosphate synthase, large subunit [IPR006275]", "Carbamoyl-phosphate synthase, small subunit [IPR006274]", "Carbohydrate sulfotransferase 8-10 [IPR018011]", "Cartilage-associated protein [IPR033212]", "Casein Kinase 2, subunit alpha [IPR045216]", "Casein kinase II, regulatory subunit [IPR000704]", "Cat eye syndrome critical region protein 5 [IPR029621]", "Catechol O-methyltransferase, eukaryotic [IPR017128]", "Catenin delta-1 [IPR028439]", "Cation efflux protein [IPR002524]", "Cation-dependent mannose-6-phosphate receptor [IPR000296]", "Cdc37 [IPR004918]", "Cdc42 [IPR037874]", "Cdc73/Parafibromin [IPR007852]", "Cell cycle and apoptosis regulator protein 2 [IPR028811]", "Cell cycle and apoptosis regulator protein [IPR025224]", "Cell division cycle protein 123 [IPR009772]", "Cell division protein borealin [IPR018867]", "Cell growth-regulating nucleolar protein [IPR039999]", "Cell-cycle alteration and expression-elevated protein in tumour [IPR032337]", "Centrin 2 [IPR037629]", "Centromere protein Cenp-F [IPR043513]", "Centromere protein P [IPR027801]", "Centrosomal protein of 55kDa [IPR038926]", "Ceramide glucosyltransferase [IPR025993]", "Ceroid-lipofuscinosis neuronal protein 5 [IPR026138]", "Cgr1-like [IPR005579]", "Chaperone DnaJ [IPR012724]", "Chaperone DnaK [IPR012725]", "Chaperone tailless complex polypeptide 1 (TCP-1) [IPR017998]", "Chaperonin Cpn60/GroEL [IPR001844]", "Chaperonin Cpn60/GroEL/TCP-1 family [IPR002423]", "Chitobiosyldiphosphodolichol beta-mannosyltransferase ALG1-like [IPR026051]", "Chloride channel CLIC-like [IPR009231]", "Chloride channel ClC-3 [IPR002245]", "Chloride channel ClC-7 [IPR002249]", "Chloride channel, voltage gated [IPR001807]", "Chloride intracellular channel protein 1 [IPR030259]", "Chloride intracellular channel protein 4/6 [IPR030257]", "Choline/ethanolamine phosphotransferase [IPR014472]", "Chondroitin N-acetylgalactosaminyltransferase [IPR008428]", "Chromatin assembly factor 1 subunit A [IPR022043]", "Chromatin assembly factor 1 subunit Cac2/CHAF1B/FAS2 [IPR045145]", "Chromatin-remodeling complex component Sfh1/SNF5 [IPR017393]", "Chromobox protein homolog 2 [IPR042796]", "Chromobox protein homologue 3 [IPR038033]", "Chromosome alignment-maintaining phosphoprotein 1 [IPR039330]", "Cilia- and flagella-associated protein 20/CFAP20DC [IPR040441]", "Cip1-interacting zinc finger protein [IPR026811]", "Citrate synthase [IPR002020]", "Citrate synthase, eukaryotic-type [IPR010109]", "Class I-like SAM-dependent O-methyltransferase [IPR002935]", "Clathrin adaptor, mu subunit [IPR001392]", "Clathrin coat assembly protein AP180-like [IPR045192]", "Clathrin interactor 1 [IPR030544]", "Clathrin, heavy chain [IPR016341]", "Cleavage and polyadenylation specificity factor subunit 6 [IPR034769]", "Cleavage and polyadenylation specificity factor subunit 7 [IPR034770]", "Cleavage stimulation factor subunit 1-like [IPR044633]", "Cleavage stimulation factor subunit 2 [IPR033105]", "Cleavage/polyadenylation specificity factor subunit 5 [IPR016706]", "Cleft lip and palate transmembrane 1 [IPR008429]", "Cleft lip and palate transmembrane protein 1-like protein [IPR030434]", "Clp protease proteolytic subunit /Translocation-enhancing protein TepA [IPR023562]", "Clp protease, ATP-binding subunit ClpX [IPR004487]", "ClpA/B family [IPR001270]", "Co-chaperone protein p23-like [IPR045250]", "Coactosin-like protein [IPR030502]", "Coatomer alpha subunit [IPR016391]", "Coatomer beta subunit (COPB1) [IPR016460]", "Coatomer beta' subunit (COPB2) [IPR016453]", "Coatomer delta subunit [IPR027059]", "Coatomer gamma subunit [IPR017106]", "Coatomer subunit zeta [IPR039652]", "Coatomer, epsilon subunit [IPR006822]", "Cobalamin-dependent methionine synthase [IPR011822]", "Cofactor of BRCA1 [IPR010405]", "Cofilin 1 [IPR027234]", "Cohesin subunit Scc3/SA [IPR039662]", "Coiled-coil domain-containing protein 124/Oxs1 [IPR010422]", "Coiled-coil domain-containing protein 138 [IPR038798]", "Coiled-coil domain-containing protein 22 [IPR008530]", "Coiled-coil domain-containing protein 86 [IPR026570]", "Coilin [IPR024822]", "Condensin complex subunit 2/barren [IPR022816]", "Condensin complex subunit 3 [IPR027165]", "Condensin subunit 1 [IPR007673]", "Condensin subunit 1/Condensin-2 complex subunit D3 [IPR026971]", "Copine [IPR045052]", "Copper chaperone SCO1/SenC [IPR003782]", "Coproporphyrinogen III oxidase, aerobic [IPR001260]", "Core histone macro-H2A [IPR021171]", "Coronin 1A [IPR029508]", "Coronin 1C [IPR027333]", "Coronin 7 [IPR027331]", "Coronin [IPR015505]", "Cortactin [IPR015503]", "Cullin [IPR045093]", "Cullin-4B [IPR033044]", "Cullin-associated NEDD8-dissociated protein 1/2 [IPR039852]", "Cwf19-like protein [IPR040194]", "Cyclic nucleotide phosphodiesterase [IPR008431]", "Cyclin [IPR039361]", "Cyclin-dependent kinase 6 [IPR028788]", "Cyclophilin-RNA interacting protein [IPR035542]", "Cyclophilin-type peptidyl-prolyl cis-trans isomerase [IPR024936]", "Cys/Met metabolism, pyridoxal phosphate-dependent enzyme [IPR000277]", "Cysteine-tRNA ligase [IPR015803]", "Cysteinyl-tRNA synthetase/mycothiol ligase [IPR024909]", "Cystinyl aminopeptidase [IPR034017]", "Cytochrome B561-related [IPR019176]", "Cytochrome P450 [IPR001128]", "Cytochrome P450, E-class, group I [IPR002401]", "Cytochrome P450, E-class, group IV [IPR002403]", "Cytochrome b-c1 complex subunit 8 [IPR004205]", "Cytochrome b-c1 complex subunit 9 [IPR008027]", "Cytochrome c oxidase subunit 6C [IPR004204]", "Cytochrome c oxidase subunit IV [IPR013288]", "Cytochrome c oxidase subunit IV family [IPR004203]", "Cytochrome c oxidase subunit VII [IPR039297]", "Cytochrome c oxidase subunit VIIa, metazoa [IPR003177]", "Cytochrome c oxidase, subunit Va/VI [IPR003204]", "Cytochrome c/quinol oxidase subunit II [IPR045187]", "Cytochrome c1 [IPR002326]", "Cytoplasmic FMR1-interacting [IPR008081]", "Cytoplasmic dynein 2 heavy chain 1 [IPR026815]", "Cytoplasmic tRNA 2-thiolation protein 2 [IPR019407]", "Cytoskeleton-associated protein 2 family [IPR026165]", "Cytoskeleton-associated protein 4 [IPR028428]", "Cytosolic Fe-S cluster assembly factor NUBP2/Cfd1, eukaryotes [IPR028600]", "Cytosolic acyl coenzyme A thioester hydrolase [IPR040170]", "Cytosolic nonspecific dipeptidase/DUG1 [IPR017153]", "D-3-phosphoglycerate dehydrogenase [IPR006236]", "DDRGK domain containing protein [IPR019153]", "DDX54/DBP10 family [IPR033517]", "DENR family, eukaryotes [IPR005873]", "DNA (cytosine-5)-methyltransferase 1-like [IPR017198]", "DNA damage-binding protein 1 [IPR031297]", "DNA double-strand break repair protein Mre11 [IPR003701]", "DNA fragmentation factor 45 [IPR017299]", "DNA helicase, ATP-dependent, RecQ type [IPR004589]", "DNA ligase, ATP-dependent [IPR000977]", "DNA mismatch repair Msh2-type [IPR011184]", "DNA mismatch repair MutS family [IPR045076]", "DNA mismatch repair protein Msh2 [IPR032642]", "DNA mismatch repair protein MutS/MSH [IPR017261]", "DNA polymerase V/Myb-binding protein 1A [IPR007015]", "DNA polymerase alpha, subunit B [IPR016722]", "DNA polymerase delta subunit 3 [IPR019038]", "DNA polymerase delta/II small subunit family [IPR024826]", "DNA polymerase epsilon catalytic subunit [IPR029703]", "DNA primase large subunit, eukaryotic/archaeal [IPR007238]", "DNA primase, large subunit, eukaryotic [IPR016558]", "DNA primase, small subunit [IPR002755]", "DNA primase, small subunit, eukaryotic/archaeal [IPR014052]", "DNA repair protein Rad50, eukaryotes [IPR004584]", "DNA repair/transcription protein MET18/MMS19 [IPR039920]", "DNA replication ATP-dependent helicase/nuclease Dna2 [IPR026851]", "DNA replication licensing factor Mcm2 [IPR008045]", "DNA replication licensing factor Mcm3 [IPR008046]", "DNA replication licensing factor Mcm5 [IPR008048]", "DNA replication licensing factor Mcm6 [IPR008049]", "DNA replication licensing factor Mcm7 [IPR008050]", "DNA topoisomerase I [IPR001631]", "DNA topoisomerase II, eukaryotic-type [IPR001154]", "DNA topoisomerase II-beta [IPR028467]", "DNA topoisomerase, type IIA [IPR001241]", "DNA-directed DNA polymerase, family B [IPR006172]", "DNA-directed RNA pol I, largest subunit [IPR015699]", "DNA-directed RNA polymerase III subunit RPC3 [IPR039748]", "DNA-directed RNA polymerase, phage-type [IPR002092]", "DNA-directed RNA polymerase, subunit 2 [IPR015712]", "DNA-directed RNA polymerase, subunit beta-prime [IPR045867]", "DNA2/NAM7-like helicase [IPR045055]", "DPM1-like [IPR039528]", "Death-inducer obliterator 1 [IPR033082]", "Dedicator of cytokinesis [IPR026791]", "Defective-in-cullin neddylation protein [IPR014764]", "Delta l-pyrroline-5-carboxylate synthetase [IPR005766]", "Delta(24)-sterol reductase [IPR040165]", "Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase Ech1-like [IPR045002]", "Deoxyhypusine hydroxylase [IPR027517]", "Deoxyribonuclease II [IPR004947]", "Deoxyuridine triphosphate nucleotidohydrolase [IPR008181]", "Dephospho-CoA kinase [IPR001977]", "Derlin [IPR007599]", "Dermcidin [IPR028130]", "Dermcidin/Lacritin [IPR043557]", "Desmoglein [IPR009123]", "Desmoplakin [IPR028462]", "Desmosomal cadherin [IPR009122]", "Destrin [IPR029924]", "Deubiquitinating enzyme MINDY-3/4 [IPR039785]", "Developmentally regulated GTP-binding protein [IPR045001]", "Dihydrofolate reductase [IPR012259]", "Dihydrolipoamide acetyltransferase/Pyruvate dehydrogenase protein X component [IPR045257]", "Dihydrolipoamide dehydrogenase [IPR006258]", "Dihydrolipoamide succinyltransferase [IPR006255]", "Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex [IPR006257]", "Dihydropyrimidinase-related protein 2 [IPR030615]", "Dihydropyrimidinase-related protein 5 [IPR030626]", "Dihydroxyacetone phosphate acyltransferase [IPR028353]", "Dipeptidyl-peptidase 3 [IPR005317]", "Diphthamide synthesis DHP2 [IPR010014]", "Diphthamide synthesis DPH1/DPH2 [IPR016435]", "Diphthine synthase [IPR004551]", "DnaJ homolog subfamily A member 1/2-like [IPR044713]", "DnaJ homolog subfamily C member 8 [IPR042858]", "DnaJ homologue subfamily C member 10 [IPR021170]", "Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase [IPR039485]", "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48kDa subunit [IPR005013]", "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit Swp1 [IPR008814]", "Drebrin [IPR028438]", "Drebrin-like protein [IPR029923]", "Dual specificity protein phosphatase 12 [IPR016278]", "Dynactin subunit 3 [IPR009991]", "Dynactin subunit 4 [IPR008603]", "Dynamin [IPR022812]", "Dynamin-1-like protein [IPR030556]", "Dynamin-2 [IPR027188]", "Dynamin-like 120kDa protein, mitochondrial [IPR033047]", "Dynamitin [IPR028133]", "Dynein 1 light intermediate chain [IPR008467]", "Dynein family light intermediate chain [IPR022780]", "Dynein heavy chain [IPR026983]", "Dynein light chain, type 1/2 [IPR001372]", "Dynein regulator LIS1 [IPR017252]", "Dyslexia-associated protein KIAA0319-like [IPR029865]", "Dystrophin/utrophin [IPR035436]", "E3 UFM1-protein ligase 1 [IPR018611]", "E3 ubiquitin ligase Bre1 [IPR013956]", "E3 ubiquitin ligase RBR family [IPR031127]", "E3 ubiquitin ligase UBR4-like [IPR045189]", "E3 ubiquitin-protein ligase ARIH2 [IPR031126]", "E3 ubiquitin-protein ligase CHIP/LubX [IPR045200]", "E3 ubiquitin-protein ligase HECTD1/TRIP12-like [IPR045322]", "E3 ubiquitin-protein ligase HECTD3 [IPR042469]", "E3 ubiquitin-protein ligase RBBP6 family [IPR033489]", "E3 ubiquitin-protein ligase RING1/RING2 [IPR043540]", "E3 ubiquitin-protein ligase RING2 [IPR037937]", "E3 ubiquitin-protein ligase UBR1-like [IPR039164]", "E3 ubiquitin-protein ligase UBR7 [IPR040204]", "E3 ubiquitin-protein ligase listerin [IPR039795]", "EB1, Metazoa [IPR027739]", "EB2, vertebrate [IPR027735]", "ECSIT [IPR010418]", "EF-hand domain-containing protein D1/2 [IPR040365]", "EH domain-containing protein 1/3 [IPR029951]", "EH domain-containing protein 4 [IPR029952]", "ELL/occludin family [IPR031176]", "ELMO domain-containing protein 2 [IPR030724]", "ELP3/YhcC [IPR039661]", "ER lumen protein retaining receptor [IPR000133]", "ER membrane protein complex subunit 1 [IPR026895]", "ER membrane protein complex subunit 2-like [IPR039856]", "ER membrane protein complex subunit 7 [IPR039163]", "ERG2/sigma1 receptor-like [IPR006716]", "ERp19 [IPR037462]", "Ecd family [IPR010770]", "Electron transfer flavoprotein alpha subunit/FixB [IPR001308]", "Electron transfer flavoprotein, beta subunit [IPR012255]", "Electron transfer flavoprotein-ubiquinone oxidoreductase [IPR040156]", "Elongation factor 4 [IPR006297]", "Elongation factor G1-like [IPR045044]", "Elongator complex protein 1 [IPR006849]", "Elongator complex protein 2 [IPR037289]", "Elongator complex protein 3-like [IPR034687]", "Elongator complex protein 4 [IPR008728]", "Elongin B [IPR039049]", "Elongin-C [IPR039948]", "Emerin [IPR035004]", "Endonuclease III-like protein 1 [IPR030841]", "Endonuclease domain-containing 1 protein [IPR039015]", "Endophilin-A [IPR028501]", "Endophilin-B1 [IPR028503]", "Endoplasmic reticulum aninopeptidase 1 [IPR033520]", "Endoplasmic reticulum oxidoreductin 1 [IPR007266]", "Endoplasmic reticulum protein SC65 [IPR033213]", "Endoplasmic reticulum resident protein 29 [IPR016855]", "Endoplasmic reticulum vesicle transporter [IPR045888]", "Endosulphine [IPR006760]", "Endothelin-converting enzyme 1 [IPR029734]", "Engulfment and cell motility protein 2 [IPR030713]", "Enhancer of mRNA-decapping protein 4-like [IPR045152]", "Enhancer of rudimentary [IPR000781]", "Enolase [IPR000941]", "Enoyl-CoA hydratase/isomerase [IPR001753]", "Enoyl-CoA hydratase/isomerase, HIBYL-CoA-H type [IPR032259]", "Ependymin [IPR001299]", "Ephrin receptor type-A /type-B [IPR016257]", "Epimerase family protein SDR39U1 [IPR010099]", "Epoxide hydrolase [IPR016292]", "Epoxide hydrolase-like [IPR000639]", "Equilibrative nucleoside transporter 1 [IPR030195]", "Equilibrative nucleoside transporter [IPR002259]", "Erg28 [IPR005352]", "Ergosterol biosynthesis ERG4/ERG24 [IPR001171]", "Erlin1/2 [IPR033294]", "Esterase-like [IPR000801]", "Eukaryotic porin/Tom40 [IPR027246]", "Eukaryotic rRNA processing [IPR008610]", "Eukaryotic translation elongation factor 1 epsilon-1 [IPR042450]", "Eukaryotic translation initiation factor 2D [IPR039757]", "Eukaryotic translation initiation factor 3 subunit A [IPR027512]", "Eukaryotic translation initiation factor 3 subunit B [IPR011400]", "Eukaryotic translation initiation factor 3 subunit D [IPR007783]", "Eukaryotic translation initiation factor 3 subunit E [IPR016650]", "Eukaryotic translation initiation factor 3 subunit F [IPR027531]", "Eukaryotic translation initiation factor 3 subunit G [IPR017334]", "Eukaryotic translation initiation factor 3 subunit H [IPR027524]", "Eukaryotic translation initiation factor 3 subunit I [IPR027525]", "Eukaryotic translation initiation factor 3 subunit J [IPR013906]", "Eukaryotic translation initiation factor 3 subunit K [IPR009374]", "Eukaryotic translation initiation factor 3 subunit M [IPR027528]", "Eukaryotic translation initiation factor 3 subunit M eIF3m/COP9 signalosome complex subunit 7 COPS7 [IPR045237]", "Eukaryotic translation initiation factor 4 gamma 1 [IPR037584]", "Eukaryotic translation initiation factor 4 gamma 3 [IPR037585]", "Eukaryotic translation initiation factor 4B [IPR033107]", "Exocyst complex component EXOC2/Sec5 [IPR029175]", "Exocyst complex component EXOC3/Sec6 [IPR010326]", "Exocyst complex component EXOC5/Sec10 [IPR033960]", "Exocyst complex component Exo70 [IPR004140]", "Exocyst complex component Sec10-like [IPR009976]", "Exonuclease 1 [IPR032641]", "Exosome complex RNA-binding protein 1/RRP40/RRP4 [IPR026699]", "Exosome complex exonuclease Rrp6-like [IPR045092]", "Exportin 4/7-like [IPR044189]", "Exportin-1/5 [IPR045065]", "Exportin-5 [IPR040018]", "Exportin-7 [IPR040021]", "Exportin-T [IPR040017]", "Ezrin/radixin/moesin [IPR011174]", "Ezrin/radixin/moesin-like [IPR000798]", "F-actin-capping protein subunit alpha [IPR002189]", "F-actin-capping protein subunit beta [IPR001698]", "FACT complex subunit Spt16 [IPR040258]", "FAD synthetase with the MoaB/Mog domain [IPR012183]", "FAD-dependent glycerol-3-phosphate dehydrogenase [IPR000447]", "FAD-dependent oxidoreductase SdhA/FrdA/AprA [IPR030664]", "FAM105 [IPR023235]", "FAM175 family [IPR023238]", "FAM175 family, BRISC complex, Abro1 subunit [IPR023240]", "FAM98 [IPR018797]", "FH1/FH2 domain-containing protein 1 [IPR027647]", "FUN14 [IPR007014]", "Fanconi anemia group I protein [IPR026171]", "Fascin [IPR010431]", "Fascin, metazoans [IPR024703]", "Fascin-1 [IPR030146]", "Fatty acid oxidation complex, alpha subunit, mitochondrial [IPR012803]", "Fatty acid transport protein 2 [IPR030305]", "Fatty acid transport protein 4 [IPR030304]", "Fatty acyl-CoA reductase [IPR026055]", "Fcf2/DNTTIP2 [IPR039883]", "Ferrochelatase [IPR001015]", "Fibrillarin [IPR000692]", "Filamin family [IPR044801]", "Filamin-B [IPR029874]", "Fimbrin/Plastin [IPR039959]", "Flagellum site-determining protein YlxH/ Fe-S cluster assembling factor NBP35 [IPR033756]", "Flap endonuclease 1 [IPR023426]", "Flotillin family [IPR027705]", "Formate-tetrahydrofolate ligase, FTHFS [IPR000559]", "Formin, protein diaphanous homologue 1 [IPR027653]", "Formin, protein diaphanous homologue 3 [IPR027654]", "Fragile X mental retardation syndrome-related protein [IPR040148]", "Fructosamine/Ketosamine-3-kinase [IPR016477]", "Fructose-bisphosphate aldolase, class-I [IPR000741]", "Fumarate hydratase, class II [IPR005677]", "Fumarate lyase family [IPR000362]", "Fumarylacetoacetase [IPR005959]", "G patch domain-containing protein 11 [IPR039249]", "G-protein alpha subunit, group 12/13 [IPR000469]", "G-protein alpha subunit, group I [IPR001408]", "G-rich sequence factor 1 [IPR033106]", "G10 protein [IPR001748]", "GDP dissociation inhibitor [IPR018203]", "GH3 family [IPR004993]", "GINS complex subunit Sld5 [IPR008591]", "GINS complex, subunit Psf3 [IPR010492]", "GIR2-like [IPR040213]", "GPI mannosyltransferase [IPR005599]", "GPI transamidase component PIG-T [IPR007245]", "GRASP55/65 [IPR007583]", "GRIP1-associated protein 1 [IPR026204]", "GTP-binding protein 1 [IPR039263]", "GTP-binding protein Era [IPR005662]", "GTP-binding protein Obg/CgtA [IPR014100]", "GTP-binding protein Rheb [IPR037586]", "Galactokinase [IPR000705]", "Galectin-3 [IPR015534]", "Galectin-like [IPR044156]", "Gametogenetin-binding protein 2 [IPR026073]", "Gamma-adducin [IPR027772]", "Gamma-glutamylcyclotransferase [IPR017939]", "Gamma-tubulin complex component protein [IPR007259]", "Ganglioside GM2 activator [IPR028996]", "Gem-associated protein 4 [IPR033265]", "General transcription factor 3C polypeptide 4 [IPR044230]", "Geranylgeranyl transferase type-1 subunit beta [IPR041960]", "Geranylgeranyl transferase type-2 subunit alpha [IPR032955]", "Glia maturation factor [IPR011171]", "Glomulin/ALF4 [IPR019516]", "Glucosamine-6-phosphate isomerase [IPR004547]", "Glucosamine-fructose-6-phosphate aminotransferase, isomerising [IPR005855]", "Glucose-6-phosphate dehydrogenase [IPR001282]", "Glucosidase II beta subunit-like [IPR039794]", "Glutamate 5-kinase/delta-1-pyrroline-5-carboxylate synthase [IPR005715]", "Glutamate carboxypeptidase 2-like [IPR039373]", "Glutamate--cysteine ligase regulatory subunit [IPR032963]", "Glutamate-cysteine ligase catalytic subunit [IPR004308]", "Glutamate/acetylglutamate kinase [IPR001057]", "Glutamate/phenylalanine/leucine/valine dehydrogenase [IPR006095]", "Glutaminase [IPR015868]", "Glutamine-tRNA synthetase [IPR004514]", "Glutamyl-tRNA synthetase, archaeal/eukaryotic cytosolic [IPR004526]", "Glutamyl/glutaminyl-tRNA synthetase [IPR000924]", "Glutathione S-transferase Omega/Tau-like [IPR045073]", "Glutathione S-transferase kappa [IPR044088]", "Glutathione S-transferase, Mu class [IPR003081]", "Glutathione S-transferase, omega-class [IPR005442]", "Glutathione S-transferases, class Zeta [IPR005955]", "Glutathione Transferase family [IPR040079]", "Glutathione reductase, eukaryote/bacterial [IPR006322]", "Glutathione synthase [IPR005615]", "Glutathione-specific gamma-glutamylcyclotransferase [IPR006840]", "Glyceraldehyde-3-phosphate dehydrogenase, type I [IPR006424]", "Glyceraldehyde/Erythrose phosphate dehydrogenase family [IPR020831]", "Glycerol-3-phosphate O-acyltransferase/Dihydroxyacetone phosphate acyltransferase [IPR022284]", "Glycerol-3-phosphate acyltransferase, PlsB [IPR028354]", "Glycine cleavage system P protein [IPR020581]", "Glycine dehydrogenase (decarboxylating) [IPR003437]", "Glycogen debranching enzyme [IPR010401]", "Glycogen debranching enzyme, metazoa [IPR006421]", "Glycogen synthase kinase-3 beta [IPR033573]", "Glycogen/starch/alpha-glucan phosphorylase [IPR011833]", "Glycoside hydrolase family 30 [IPR001139]", "Glycoside hydrolase family 31 [IPR000322]", "Glycoside hydrolase family 63 [IPR004888]", "Glycoside hydrolase, family 2 [IPR006101]", "Glycoside hydrolase, family 27 [IPR002241]", "Glycoside hydrolase, family 29 [IPR000933]", "Glycoside hydrolase, family 35 [IPR001944]", "Glycosyl transferase, family 25 [IPR002654]", "Glycosyl transferase, family 35 [IPR000811]", "Glycyl-tRNA synthetase [IPR002315]", "Glycyl-tRNA synthetase/DNA polymerase subunit gamma-2 [IPR027031]", "Glyoxalase I [IPR004361]", "Glyoxalase domain-containing protein 4 [IPR043193]", "Golgi apparatus protein 1 [IPR039728]", "Golgi integral membrane protein 4 [IPR042336]", "Golgi to ER traffic protein 4 [IPR007317]", "Golgi-associated PDZ and coiled-coil motif-containing protein [IPR038879]", "Golgin subfamily A member 3 [IPR033288]", "Golgin subfamily B member 1 [IPR026202]", "Graves disease carrier protein [IPR002167]", "GroES chaperonin family [IPR020818]", "Growth arrest/ DNA-damage-inducible protein-interacting protein 1 [IPR018472]", "GrpE nucleotide exchange factor [IPR000740]", "Guanine nucleotide binding protein (G-protein), alpha subunit [IPR001019]", "Guanine nucleotide-exchange factor Sec12-like [IPR045260]", "H/ACA ribonucleoprotein complex non-core subunit Naf1 [IPR040309]", "H/ACA ribonucleoprotein complex, subunit Gar1/Naf1 [IPR007504]", "H/ACA ribonucleoprotein complex, subunit Nhp2, eukaryote [IPR002415]", "HAD hydrolase, LHPP/HDHD2 [IPR006355]", "HAD hydrolase, subfamily IA [IPR006439]", "HAD-superfamily hydrolase, subfamily IG, 5'-nucleotidase [IPR008380]", "HAD-superfamily hydrolase, subfamily IIA [IPR006357]", "HAD-superfamily hydrolase, subfamily IIA, CECR5 [IPR006353]", "HAUS augmin-like complex subunit 3 [IPR026206]", "HAUS augmin-like complex subunit 5 [IPR029131]", "HAUS complex subunit 5, metazoa [IPR026215]", "HCCA isomerase/glutathione S-transferase kappa [IPR014440]", "Haem oxygenase [IPR002051]", "Haem oxygenase-like [IPR016053]", "Haloacid dehalogenase-like hydrolase [IPR041492]", "Ham1-like protein [IPR002637]", "Heat shock 70kDa protein 13 [IPR042048]", "Heat shock protein 70 family [IPR013126]", "Heat shock protein Hsp90 family [IPR001404]", "Heat shock protein Sti1-like [IPR045248]", "Helicase MOV-10 [IPR026122]", "Helicase superfamily 1/2, DinG/Rad3-like [IPR045028]", "Heterochromatin protein 1-binding protein 3 [IPR033061]", "Heterogeneous nuclear ribonucleoprotein C [IPR017347]", "Heterogeneous nuclear ribonucleoprotein K [IPR033090]", "Heterogeneous nuclear ribonucleoprotein M [IPR024667]", "Heterogeneous nuclear ribonucleoprotein U [IPR026745]", "Heterogeneous nuclear ribonucleoprotein U-like protein 1 [IPR027025]", "Hexokinase [IPR001312]", "High mobility group protein HMG-I/HMG-Y, chordates [IPR031079]", "High mobility group protein HMGA [IPR000116]", "High mobility group protein HMGB1 [IPR031076]", "High mobility group protein HMGB3 [IPR031077]", "High mobility group protein HMGN [IPR000079]", "Histidine acid phosphatase, eukaryotic [IPR016274]", "Histidine phosphatase superfamily, clade-1 [IPR013078]", "Histidine phosphatase superfamily, clade-2 [IPR000560]", "Histone H2A [IPR002119]", "Histone H4 [IPR001951]", "Histone PARylation factor 1 [IPR019361]", "Histone acetyltransferase type B, catalytic subunit [IPR017380]", "Histone deacetylase [IPR003084]", "Histone deacetylase complex subunit SAP130 [IPR024137]", "Histone deacetylase complex, SAP18 subunit [IPR017250]", "Histone deacetylase family [IPR000286]", "Histone demethylase JHDM2-like [IPR045109]", "Histone lysine-specific demethylase [IPR017366]", "Histone methyltransferase complex subunit ASH2 [IPR037353]", "Histone-lysine N-methyltransferase 2A [IPR037927]", "Histone-lysine N-methyltransferase Smyd3 [IPR025805]", "HnRNP R/Q splicing factor [IPR006535]", "HnRNP-L/PTB [IPR006536]", "Holocytochrome c/c1 synthase [IPR000511]", "Host cell factor 1 [IPR037854]", "Host cell factor [IPR043536]", "Hydantoinase/dihydropyrimidinase [IPR011778]", "Hydroxymethylglutaryl-CoA synthase, eukaryotic [IPR010122]", "Hypoxanthine phosphoribosyl transferase [IPR005904]", "Hypoxia-inducible factor 1-alpha inhibitor [IPR027445]", "I-BAR domain containing protein IRSp53 [IPR030128]", "I-BAR domain containing protein IRSp53/IRTKS/Pinkbar [IPR027681]", "ICln [IPR003521]", "ISC system FeS cluster assembly, IscU scaffold [IPR011339]", "Immunity-related GTPase family Q protein [IPR040070]", "Impact family [IPR023582]", "Importin beta family [IPR040122]", "Importin subunit alpha [IPR024931]", "Inhibitor of nuclear factor kappa-B kinase-interacting protein [IPR024152]", "Initiation factor 2B-related [IPR000649]", "Initiation factor 4G [IPR045208]", "Inner centromere protein [IPR039130]", "Inner nuclear membrane protein Man1 [IPR034997]", "Inorganic pyrophosphatase [IPR008162]", "Inosine triphosphate pyrophosphatase [IPR027502]", "Inosine-5'-monophosphate dehydrogenase [IPR005990]", "Inositol monophosphatase-like [IPR000760]", "Insulin receptor substrate [IPR039011]", "Insulin-like growth factor 2 mRNA-binding protein 2 [IPR028743]", "Integral membrane protein 2 [IPR040145]", "Integral membrane protein EMC3/TMCO1-like [IPR002809]", "Integral membrane protein SYS1 [IPR016973]", "Integral membrane protein SYS1-related [IPR019185]", "Integrator complex subunit 14 [IPR039841]", "Integrator complex subunit 7 [IPR033060]", "Integrator complex subunit 9 [IPR027074]", "Integrin beta subunit [IPR015812]", "Integrin beta-1 subunit [IPR027071]", "Interferon-inducible double-stranded RNA-dependent protein kinase activator A [IPR033363]", "Interleukin enhancer-binding factor 3 [IPR033099]", "Intracellular chloride channel [IPR002946]", "Intraflagellar transport protein 27 homologue, eukaryotes [IPR034112]", "Intron Large complex component GCFC2-like [IPR012890]", "Isocitrate dehydrogenase NAD-dependent [IPR004434]", "Isocitrate dehydrogenase NADP-dependent [IPR004790]", "Isoleucine-tRNA ligase [IPR002301]", "Isoleucine-tRNA ligase, type 1 [IPR023585]", "Isoleucine-tRNA ligase, type 2 [IPR023586]", "Isopentenyl-diphosphate delta-isomerase, type 1 [IPR011876]", "Isoprenylcysteine carboxyl methyltransferase [IPR007269]", "Isovaleryl-CoA dehydrogenase [IPR034183]", "J-protein Zuotin/DnaJC2 [IPR044634]", "JNK-interacting protein 3/4 [IPR039911]", "JmjC domain-containing [IPR039994]", "Junction plakoglobin [IPR030461]", "KH domain-containing BBP-like [IPR045071]", "KIF-1 binding protein [IPR022083]", "KRR1 interacting protein 1 [IPR018034]", "Kae1/TsaD family [IPR017861]", "Keratin, type I [IPR002957]", "Keratinocyte-associated transmembrane protein 2 [IPR037645]", "Kinectin [IPR024854]", "Kinesin light chain [IPR002151]", "Kinesin-like protein KIF15/KIN-12E [IPR044986]", "Kinesin-like protein KIF20A [IPR027326]", "Kinesin-like protein KIF22 (Kid) [IPR026986]", "Kinesin-like protein [IPR027640]", "Kinetochore protein Spc25 [IPR045143]", "Ku70 [IPR006165]", "Ku80 [IPR024193]", "L-lactate dehydrogenase [IPR011304]", "L-lactate/malate dehydrogenase [IPR001557]", "LAMTOR1/MEH1 [IPR028209]", "LAR-interacting protein, Liprin [IPR029515]", "LEM domain-containing protein 2 [IPR034994]", "LETM1/MDM38-like [IPR044202]", "LIM domain and actin-binding protein 1 [IPR028740]", "LIM domain and actin-binding protein LIMA-like [IPR045268]", "La domain containing protein [IPR045180]", "LanC-like protein, eukaryotic [IPR020464]", "Lanthionine synthetase C-like [IPR007822]", "Las1 [IPR007174]", "Lecithin:cholesterol/phospholipid:diacylglycerol acyltransferase [IPR003386]", "Lethal(2) giant larvae protein [IPR000664]", "Leucine-rich PPR motif-containing protein [IPR033490]", "Leucine-rich repeat protein SHOC2 [IPR027036]", "Leucine-tRNA ligase [IPR002302]", "Leucyl-tRNA synthetase, class Ia, archaeal/eukaryotic cytosolic [IPR004493]", "Leukotriene A4 hydrolase/leucine aminopeptidase [IPR012777]", "Leukotriene B4 12-hydroxydehydrogenase/15-oxo-prostaglandin 13-reductase [IPR014190]", "Like-Sm (LSM) domain containing protein, LSm4/SmD1/SmD3 [IPR027141]", "Linker histone H1/H5 [IPR005819]", "Lipase, eukaryotic [IPR025483]", "Lipid droplet-associated hydrolase [IPR019363]", "Liprin-alpha-1 [IPR030438]", "Lon protease [IPR027065]", "Lon protease homologue, chloroplastic/mitochondrial [IPR027503]", "Lon protease, bacterial/eukaryotic-type [IPR004815]", "Long-chain fatty acid CoA synthetase, eukaryotic [IPR045311]", "Low temperature viability protein Ltv1 [IPR007307]", "Luc7-related [IPR004882]", "Lupus La protein [IPR002344]", "Lysine-tRNA ligase, class II [IPR002313]", "Lysophosphatidylserine lipase ABHD12 [IPR026605]", "Lysosomal thioesterase PPT2 [IPR030295]", "Lysosome membrane protein II [IPR005429]", "Lysosome-associated membrane glycoprotein [IPR002000]", "M-phase inducer phosphatase [IPR000751]", "M-phase phosphoprotein 6 [IPR019324]", "MCU family [IPR039055]", "MDN2-binding protein [IPR039061]", "MICOS complex subunit MIC19/MIC25 [IPR007964]", "MICOS complex subunit MIC26/MIC27 [IPR019166]", "MICOS complex subunit MIC26/MIC27, animal [IPR033182]", "MICOS complex subunit Mic13 [IPR026769]", "MKRN-like [IPR045072]", "MRG [IPR008676]", "MRPS27/PTCD2 [IPR034913]", "Macrophage migration inhibitory factor [IPR001398]", "Mad2-like [IPR045091]", "Major facilitator superfamily [IPR011701]", "Malate dehydrogenase, NAD-dependent, cytosolic [IPR011274]", "Malate dehydrogenase, type 1 [IPR010097]", "Malate dehydrogenase, type 2 [IPR010945]", "Malectin [IPR039155]", "Malic oxidoreductase [IPR001891]", "Manganese/iron superoxide dismutase [IPR001189]", "Mannose-6-phosphate isomerase [IPR016305]", "Mannose-6-phosphate isomerase, type I [IPR001250]", "Mannose-6-phosphate receptor [IPR028927]", "Med25/PTOV1 [IPR045105]", "Mediator complex, subunit Med21 [IPR021384]", "Mediator complex, subunit Med23 [IPR021629]", "Mediator complex, subunit Med24, [IPR021429]", "Mediator complex, subunit Med4 [IPR019258]", "Medium-chain dehydrogenase/reductase [IPR045010]", "Medium-chain specific acyl-CoA dehydrogenase [IPR034180]", "Melanoma-associated antigen D2 [IPR028810]", "Melanoma-associated antigen [IPR037445]", "Membralin [IPR019144]", "Membrane insertase YidC/ALB3/OXA1/COX18 [IPR001708]", "Membrane bound O-acyl transferase, MBOAT [IPR004299]", "Membrane magnesium transporter [IPR018937]", "Membrane-associated, eicosanoid/glutathione metabolism (MAPEG) protein [IPR001129]", "Mesoderm induction early response protein/metastasis-associated protein [IPR040138]", "Metal-dependent protein hydrolase [IPR003226]", "Metastasis-associated protein MTA2 [IPR037964]", "Methionine-tRNA ligase, type 1 [IPR023458]", "Methionyl-tRNA synthetase [IPR014758]", "Methyl-CpG binding protein MeCP2 [IPR017353]", "Methyl-CpG binding protein MeCP2/MBD4 [IPR045138]", "Methyl-CpG-binding domain protein 3 [IPR037965]", "Methylcrotonoyl-CoA carboxylase beta chain MCCB/AccD1-like [IPR045190]", "Methylmalonate-semialdehyde dehydrogenase [IPR010061]", "Methylthioadenosine phosphorylase (MTAP) [IPR010044]", "Methyltransferase, trithorax [IPR016569]", "Mevalonate kinase [IPR006205]", "Mevalonate/galactokinase [IPR006206]", "Microtubule associated protein 1 [IPR026074]", "Microtubule-associated protein 1B [IPR027321]", "Microtubule-associated protein 1S [IPR027322]", "Microtubule-associated protein 4 [IPR027323]", "Microtubule-associated protein Jupiter [IPR033335]", "Microtubule-associated protein RP/EB [IPR027328]", "Midasin [IPR012099]", "Midline-1 [IPR027727]", "Mini-chromosome maintenance complex protein 4 [IPR008047]", "Mini-chromosome maintenance complex-binding protein [IPR019140]", "Mini-chromosome maintenance protein [IPR031327]", "Mitochondria fission 1 protein [IPR016543]", "Mitochondrial 28S ribosomal protein S31 [IPR026299]", "Mitochondrial 28S ribosomal protein S34 [IPR032053]", "Mitochondrial ATP synthase subunit g, animal [IPR016702]", "Mitochondrial ATPase inhibitor [IPR007648]", "Mitochondrial F1-F0 ATP synthase subunit F, predicted [IPR019344]", "Mitochondrial Rho GTPase 1 [IPR029506]", "Mitochondrial Rho GTPase [IPR021181]", "Mitochondrial antiviral-signalling protein, metazoan [IPR026148]", "Mitochondrial carrier UCP-like [IPR002030]", "Mitochondrial carrier protein [IPR002067]", "Mitochondrial glycoprotein [IPR003428]", "Mitochondrial import inner membrane translocase subunit Tim44 [IPR017303]", "Mitochondrial import inner membrane translocase subunit Tim50 [IPR027111]", "Mitochondrial import inner membrane translocase subunit Tim8/13 [IPR039238]", "Mitochondrial import receptor subunit TOM5, metazoa [IPR029179]", "Mitochondrial import receptor subunit Tom22 [IPR005683]", "Mitochondrial inner membrane protein Mitofilin [IPR019133]", "Mitochondrial inner membrane translocase complex, subunit Tim17 [IPR005678]", "Mitochondrial inner membrane translocase complex, subunit Tim23 [IPR005681]", "Mitochondrial outer membrane translocase complex, subunit Tom5 [IPR019603]", "Mitochondrial phosphate carrier protein Pic2/Mir1-like [IPR044677]", "Mitochondrial processing peptidase subunit beta [IPR037718]", "Mitochondrial pyruvate carrier [IPR005336]", "Mitochondrial ribonuclease P catalytic subunit [IPR033495]", "Mitochondrial ribosomal protein L48 [IPR027487]", "Mitochondrial-processing peptidase subunit alpha [IPR037715]", "Mitofusin family [IPR027094]", "Mitofusin-2 [IPR027089]", "Mitogen-activated protein (MAP) kinase phosphatase [IPR008343]", "Mitogen-activated protein (MAP) kinase, ERK1/2 [IPR008349]", "Mitotic spindle checkpoint protein Bub1/Mad3 [IPR015661]", "Mo25-like [IPR013878]", "Molecular chaperone regulator BAG [IPR039773]", "Molybdate-anion transporter [IPR008509]", "Molybdate-anion transporter, animal type [IPR030163]", "Monocarboxylate transporter 1 [IPR030757]", "Monocarboxylate transporter [IPR004743]", "Monothiol glutaredoxin-related [IPR004480]", "Mortality factor 4-like protein 1 [IPR038011]", "Mortality factor 4-like protein 2 [IPR038012]", "Mpv17/PMP22 [IPR007248]", "Mrp/NBP35 ATP-binding protein [IPR019591]", "Multidrug resistance protein 1 [IPR030258]", "Multiple myeloma tumor-associated protein 2-like [IPR039207]", "Myeloid-derived growth factor [IPR018887]", "Myo-inositol-1-phosphate synthase [IPR002587]", "Myotubularin family [IPR030564]", "Myotubularin-related protein 6 [IPR030581]", "Myristoyl-CoA:protein N-myristoyltransferase [IPR000903]", "Myristoylated alanine-rich C-kinase substrate MARCKS [IPR002101]", "N-acetylglucosamine-6-sulfatase [IPR012251]", "N-acetylglucosamine-6-sulfatase, metazoan [IPR015981]", "N-acetyltransferase B complex, non-catalytic subunit [IPR019183]", "N-alpha-acetyltransferase 40 [IPR039949]", "N-terminal acetyltransferase A, auxiliary subunit [IPR021183]", "NAD(P) transhydrogenase, alpha subunit [IPR026255]", "NAD(P)H-quinone oxidoreductase subunit D/H [IPR022885]", "NAD/FAD transporter SLC25A32-like [IPR044712]", "NADH dehydrogenase, subunit C [IPR010218]", "NADH ubiquinone oxidoreductase, F subunit [IPR011537]", "NADH-quinone oxidoreductase subunit E-like [IPR002023]", "NADH-ubiquinone oxidoreductase, 20 Kd subunit [IPR006138]", "NADH-ubiquinone oxidoreductase, subunit 10 [IPR019377]", "NADH-ubiquinone reductase complex 1 MLRQ subunit [IPR010530]", "NADH:cytochrome b5 reductase-like [IPR001834]", "NADH:ubiquinone oxidoreductase, NDUFB5/SGDH subunit [IPR019173]", "NADH:ubiquinone oxidoreductase, subunit G [IPR010228]", "NADH:ubiquinone oxidoreductase, subunit NDUFB4 [IPR009866]", "NADPH-cytochrome P450 reductase [IPR023208]", "NDRG [IPR004142]", "NEDD8 ultimate buster 1 [IPR039749]", "NEDD8-activating enzyme E1 catalytic subunit [IPR030468]", "NEDD8-activating enzyme E1 regulatory subunit APP-BP1 [IPR030667]", "NF-kappa-B/Dorsal [IPR000451]", "NOL6/Upt22 [IPR005554]", "NPC1-like [IPR004765]", "NSF attachment protein [IPR000744]", "Na(+)/H(+) exchange regulatory cofactor NHERF-1 [IPR031199]", "Na(+)/H(+) exchange regulatory cofactor NHERF-1/2 [IPR017300]", "Nck-associated protein 1 [IPR019137]", "Negative cofactor 2 complex subunit beta [IPR042225]", "Negative elongation factor E [IPR033102]", "Nesprin-2 [IPR030266]", "Nestin [IPR031211]", "Neurochondrin [IPR008709]", "Neurofilament light polypeptide [IPR027692]", "Neurofilament medium polypeptide [IPR027697]", "Neuropilin [IPR014648]", "Neuropilin-1 [IPR027146]", "Niban-like [IPR026088]", "Nibrin [IPR016592]", "Nibrin-related [IPR040227]", "Nicalin [IPR016574]", "Nicastrin [IPR008710]", "Nicotinamide phosphoribosyl transferase [IPR016471]", "Nitric oxide synthase-interacting protein [IPR016818]", "Nonaspanin (TM9SF) [IPR004240]", "Not2/Not3/Not5 [IPR040168]", "Nuclear RNA export factor [IPR030217]", "Nuclear cap-binding protein subunit 1 [IPR027159]", "Nuclear factor hnRNPA1 [IPR021662]", "Nuclear fragile X mental retardation-interacting protein 2 [IPR032747]", "Nuclear mitotic apparatus protein 1 [IPR026650]", "Nuclear polyadenylated RNA-binding protein Nab2/ZC3H14 [IPR040366]", "Nuclear pore complex protein NUP98-NUP96 [IPR037637]", "Nuclear pore complex protein Nup133-like [IPR037624]", "Nuclear pore complex protein [IPR026054]", "Nuclear pore glycoprotein p62, metazoa [IPR033072]", "Nuclear pore membrane glycoprotein 210-like [IPR045197]", "Nuclear pore protein 84/107 [IPR007252]", "Nuclear protein localization protein 4 [IPR016563]", "Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 [IPR026633]", "Nucleobindin [IPR040250]", "Nucleobindin-1 [IPR040253]", "Nucleobindin-2 [IPR028813]", "Nucleolar GTP-binding protein 1 [IPR024926]", "Nucleolar GTP-binding protein 2 [IPR024929]", "Nucleolar complex protein 2 [IPR005343]", "Nucleolar complex protein 4 [IPR027193]", "Nucleolar complex-associated protein 3 [IPR016903]", "Nucleolar pre-ribosomal-associated protein 1 [IPR039844]", "Nucleolar protein 10/Enp2 [IPR040382]", "Nucleolar protein 11 [IPR042859]", "Nucleolar protein 14 [IPR007276]", "Nucleolar protein 7 [IPR039626]", "Nucleolar protein Nop56/Nop58 [IPR045056]", "Nucleolar, Nop52 [IPR010301]", "Nucleoplasmin family [IPR004301]", "Nucleoporin NSP1/NUP62 [IPR026010]", "Nucleoporin NUP88/NUP82 [IPR037700]", "Nucleoporin Nup120/160 [IPR021717]", "Nucleoporin Nup186/Nup192/Nup205 [IPR021827]", "Nucleoporin Nup188 [IPR044840]", "Nucleoporin Nup37 [IPR037626]", "Nucleoporin Nup54/Nup57/Nup44 [IPR024864]", "Nucleoporin Nup85-like [IPR011502]", "Nucleoporin Nup88 [IPR019321]", "Nucleoporin Seh1 [IPR037597]", "Nucleoporin interacting component Nup93/Nic96 [IPR007231]", "Nucleoporin peptidase S59-like [IPR037665]", "Nucleoporin protein Ndc1-Nup [IPR019049]", "Nucleoporin, Nup155-like [IPR004870]", "Nucleoside 2-deoxyribosyltransferase [IPR007710]", "Nucleoside diphosphate kinase 6 [IPR037994]", "Nucleoside diphosphate kinase 7 [IPR011410]", "Nucleoside diphosphate kinase [IPR001564]", "Nucleoside transporter ENT1/ENT2 [IPR034764]", "Nucleoside-triphosphatase, THEP1 type [IPR004948]", "Nucleosome assembly protein (NAP) [IPR002164]", "Nucleosome-remodeling factor subunit BPTF [IPR038028]", "NudC family [IPR037898]", "OBG-type GTPase [IPR045086]", "OCIA domain-containing protein 1/2 [IPR040187]", "Occludin [IPR002958]", "Oligosaccharyl transferase, STT3 subunit [IPR003674]", "Optic atrophy 3-like [IPR010754]", "Ornithine aminotransferase [IPR010164]", "Orotate phosphoribosyltransferase [IPR023031]", "Orotidine 5'-phosphate decarboxylase [IPR014732]", "Oxidized purine nucleoside triphosphate [IPR003563]", "Oxysterol-binding protein [IPR000648]", "P-type ATPase [IPR001757]", "P-type ATPase subfamily IIC, subunit alpha [IPR005775]", "P-type ATPase, subfamily IIA, SERCA-type [IPR005782]", "P-type ATPase, subfamily V [IPR006544]", "P-type ATPase, subfamily IB [IPR027256]", "P-type ATPase, subfamily IIA, PMR1-type [IPR006413]", "PA2G4 family [IPR004545]", "PAT complex subunit CCDC47 [IPR012879]", "PCNA-associated factor [IPR040444]", "PDCD5-like [IPR002836]", "PDK/BCKDK protein kinase [IPR039028]", "PDZ and LIM domain protein 1 [IPR028537]", "PEST proteolytic signal-containing nuclear protein [IPR029169]", "PH-interacting protein [IPR028738]", "PHF5-like [IPR005345]", "PITH domain-containing protein 1-like [IPR045099]", "PSME3-interacting protein [IPR039845]", "Pachytene checkpoint protein 2-like [IPR044539]", "Palmitoyl protein thioesterase [IPR002472]", "Palmitoyl-protein thioesterase 1 [IPR030294]", "Pantothenate kinase, acetyl-CoA regulated, two-domain type [IPR015844]", "Paraneoplastic encephalomyelitis antigen [IPR002343]", "Paraoxonase2 [IPR008364]", "Pat1-like [IPR039900]", "Pentatricopeptide repeat domain-containing protein 3 [IPR037387]", "Peptidase A22B, signal peptide peptidase [IPR007369]", "Peptidase C13, legumain [IPR001096]", "Peptidase C1B, bleomycin hydrolase [IPR004134]", "Peptidase C2, calpain family [IPR022684]", "Peptidase C26 [IPR011697]", "Peptidase C26, gamma-glutamyl hydrolase [IPR015527]", "Peptidase C65, otubain [IPR019400]", "Peptidase C69, dipeptidase A [IPR005322]", "Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase [IPR001930]", "Peptidase M1, aminopeptidase B [IPR015571]", "Peptidase M13 [IPR000718]", "Peptidase M14B, caboxypeptidase D [IPR015567]", "Peptidase M17, leucine aminopeptidase [IPR023042]", "Peptidase M17, leucine aminopeptidase/peptidase B [IPR011356]", "Peptidase M20 [IPR002933]", "Peptidase M28 family [IPR045175]", "Peptidase M3A/M3B [IPR045090]", "Peptidase S10, serine carboxypeptidase [IPR001563]", "Peptidase S26B [IPR001733]", "Peptidase S28 [IPR008758]", "Peptidase S8, subtilisin-related [IPR015500]", "Peptidase S9A, prolyl oligopeptidase [IPR002470]", "Peptidase T1A, proteasome beta-subunit [IPR000243]", "Peptidase T2, asparaginase 2 [IPR000246]", "Peptidase family M49 [IPR039461]", "Peptidase, FtsH [IPR005936]", "Peptide chain release factor eRF1/aRF1 [IPR004403]", "Peptidyl-prolyl cis-trans isomerase FKBP3 [IPR043368]", "Peptidyl-prolyl cis-trans isomerase FKBP4 [IPR031212]", "Peptidyl-prolyl cis-trans isomerase FKBP5 [IPR031210]", "Peptidyl-prolyl cis-trans isomerase PIN4 [IPR043323]", "Peptidyl-tRNA hydrolase, PTH2 [IPR002833]", "Pericentriolar material 1 protein [IPR024138]", "Perilipin [IPR004279]", "Periodic tryptophan protein 1 [IPR044285]", "Periodic tryptophan protein 2 [IPR027145]", "Periphilin-1 [IPR028851]", "Peroxiredoxin, AhpC-type [IPR024706]", "Peroxiredoxin-5-like [IPR037944]", "Peroxiredoxin-like 2A [IPR032802]", "Peroxiredoxin-like 2A/B/C [IPR032801]", "Peroxisomal acyl-coenzyme A oxidase [IPR034171]", "Peroxisomal membrane protein 14 [IPR025655]", "Peroxysomal long chain fatty acyl transporter [IPR005283]", "Pescadillo [IPR010613]", "Pex19 protein [IPR006708]", "Phenylalanine-tRNA ligase, class IIc, beta subunit [IPR045060]", "Phenylalanyl-tRNA synthetase, class IIc, alpha subunit [IPR004529]", "Phenylalanyl-tRNA synthetase, class IIc, beta subunit, archael/eukaryotic type [IPR004531]", "Phosducin-like [IPR045037]", "Phosphatidate cytidylyltransferase, mitochondrial [IPR015222]", "Phosphatidyl serine synthase [IPR004277]", "Phosphatidylethanolamine-binding protein [IPR008914]", "Phosphatidylethanolamine-binding protein, eukaryotic [IPR035810]", "Phosphatidylinositol kinase [IPR015433]", "Phosphatidylinositol transfer protein [IPR001666]", "Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma [IPR016279]", "Phosphatidylinositol-4-phosphate 5-kinase [IPR023610]", "Phosphatidylinositol-binding clathrin assembly protein [IPR030412]", "Phosphatidylserine decarboxylase [IPR033177]", "Phosphatidylserine decarboxylase, eukaryotic type 1 [IPR033661]", "Phosphatidylserine decarboxylase-related [IPR003817]", "Phosphoacetylglucosamine mutase [IPR016657]", "Phosphodiesterase MJ0936/Vps29 [IPR000979]", "Phosphoenolpyruvate carboxykinase, GTP-utilising [IPR008209]", "Phosphoglucomutase [IPR045244]", "Phosphoglucose isomerase (PGI) [IPR001672]", "Phosphoglycerate kinase [IPR001576]", "Phosphoglycerate mutase 1 [IPR005952]", "Phosphoinositide phospholipase C family [IPR001192]", "Phospholipase B-like [IPR007000]", "Phosphoribosylformylglycinamidine cyclo-ligase [IPR004733]", "Phosphoribosylformylglycinamidine synthase PurL [IPR010073]", "Phosphoribosylglycinamide formyltransferase [IPR004607]", "Phosphoribosylglycinamide synthetase [IPR000115]", "Phosphorylase kinase alpha/beta subunit [IPR008734]", "Phosphoserine aminotransferase [IPR022278]", "Phosphotyrosyl phosphatase activator, PTPA [IPR004327]", "Pinin [IPR039853]", "Pirin [IPR012093]", "Plakin [IPR043197]", "Plakophilin/Delta catenin [IPR028435]", "Plasminogen activator inhibitor 1 RNA-binding protein [IPR027205]", "Plastin-2/3 [IPR039956]", "Plectin [IPR030269]", "Podocalyxin [IPR017403]", "Polo kinase kinase [IPR022165]", "Poly(A) polymerase [IPR014492]", "Poly-U binding splicing factor, PUF60-like [IPR006532]", "Polyadenylate binding protein, human types 1, 2, 3, 4 [IPR006515]", "Polyadenylate-binding protein 2 [IPR034911]", "Polyprenyl synthetase [IPR000092]", "Polyribonucleotide 5-hydroxyl-kinase Clp1/Grc3 [IPR045116]", "Polyribonucleotide nucleotidyltransferase [IPR012162]", "Porin, eukaryotic type [IPR001925]", "Porphobilinogen deaminase [IPR000860]", "Pre-mRNA 3' end processing protein Pfs2-like [IPR045245]", "Pre-mRNA-processing factor 17 [IPR032847]", "Pre-mRNA-processing factor 19 [IPR038959]", "Pre-mRNA-processing factor 6/Prp1/STA1 [IPR027108]", "Pre-mRNA-processing factor Prp40 [IPR039726]", "Pre-mRNA-processing-splicing factor 8 [IPR027652]", "Pre-mRNA-splicing factor 38 [IPR005037]", "Pre-mRNA-splicing factor Cwc2/Slt11 [IPR039171]", "Pre-mRNA-splicing factor Spp2-like [IPR045166]", "Pre-mRNA-splicing factor Syf1-like [IPR045075]", "Pre-mRNA-splicing regulator WTAP [IPR033757]", "Pre-rRNA-processing protein Esf1 [IPR039754]", "Pre-rRNA-processing protein PNO1-like [IPR039912]", "Prefoldin alpha subunit, archaea-type [IPR011599]", "Prefoldin alpha-like [IPR004127]", "Prefoldin beta-like [IPR002777]", "Prefoldin subunit 2 [IPR027235]", "Prefoldin subunit 3 [IPR016655]", "Prefoldin, subunit 4 [IPR016661]", "Prenylated rab acceptor PRA1 [IPR004895]", "Prenylcysteine oxidase [IPR017046]", "Prenyltransferase subunit beta [IPR045089]", "Presenilin/signal peptide peptidase [IPR006639]", "Primosome PriB/single-strand DNA-binding [IPR000424]", "Probable E3 ubiquitin-protein ligase makorin-2 [IPR026293]", "Probable ubiquitin carboxyl-terminal hydrolase FAF-X [IPR031226]", "Profilin [IPR005455]", "Profilin-1 [IPR029892]", "Profilin-2 [IPR029891]", "Profilin1/2/3, vertebrate [IPR005454]", "Programmed cell death protein 4 [IPR039778]", "Prohibitin [IPR000163]", "Proliferating cell nuclear antigen, PCNA [IPR000730]", "Proline-rich protein PRCC [IPR018800]", "Proline-tRNA ligase, class IIa, archaeal-type [IPR004499]", "Prolyl 3-hydroxylase 1 [IPR039837]", "Prolyl 3-hydroxylase [IPR039575]", "Prolyl 4-hydroxylase [IPR045054]", "Prostaglandin E synthase 2 [IPR034334]", "Prostaglandin reductase 2 [IPR037399]", "Proteasomal ubiquitin receptor Rpn13/ADRM1 [IPR006773]", "Proteasome B-type subunit [IPR023333]", "Proteasome activator PA28 [IPR009077]", "Proteasome activator complex subunit 4 [IPR035309]", "Proteasome alpha-type subunit [IPR023332]", "Proteasome assembly chaperone 1 [IPR016565]", "Proteasome assembly chaperone 2 [IPR019151]", "Proteasome assembly chaperone 2, eukaryotic [IPR016562]", "Proteasome beta 3 subunit [IPR033811]", "Proteasome component Ecm29 [IPR024372]", "Proteasome inhibitor PI31-like [IPR045128]", "Proteasome subunit alpha 1 [IPR035144]", "Proteasome subunit alpha 3 [IPR037555]", "Proteasome subunit alpha 7 [IPR035190]", "Proteasome subunit alpha2 [IPR034644]", "Proteasome subunit alpha4 [IPR034647]", "Proteasome subunit alpha5 [IPR033812]", "Proteasome subunit alpha6 [IPR034642]", "Proteasome subunit beta 1 [IPR035202]", "Proteasome subunit beta 2 [IPR035206]", "Proteasome subunit beta 4 [IPR016295]", "Proteasome subunit beta 5 [IPR037558]", "Proteasome subunit beta 6 [IPR035140]", "Proteasome subunit beta 7 [IPR035216]", "Proteasome, subunit alpha/beta [IPR001353]", "Protein AATF/Bfr2 [IPR039223]", "Protein BRAWNIN [IPR027858]", "Protein CDV3 [IPR026806]", "Protein CIP2A [IPR042510]", "Protein DEK [IPR044198]", "Protein ERGIC-53 [IPR033085]", "Protein FAM8A1 [IPR039871]", "Protein FRG1 [IPR010414]", "Protein ICln/Lot5/Saf5 [IPR039924]", "Protein LCHN/Anr2 [IPR018626]", "Protein LYRIC [IPR031402]", "Protein Lsm12-like [IPR039683]", "Protein NDRG3 [IPR030692]", "Protein Njmu-R1 [IPR028280]", "Protein PBDC1, metazoa/fungi [IPR008476]", "Protein PRRC1 [IPR026534]", "Protein PRRC2 [IPR033184]", "Protein Peter Pan-like [IPR045112]", "Protein RCC2 [IPR028641]", "Protein Red-like [IPR039896]", "Protein S100-A10 [IPR028476]", "Protein S100-A11 [IPR028482]", "Protein S100-A13 [IPR028487]", "Protein SON [IPR032922]", "Protein Sgt1-like [IPR044563]", "Protein TFG [IPR033512]", "Protein arginine N-methyltransferase PRMT5 [IPR007857]", "Protein arginine N-methyltransferase [IPR025799]", "Protein arginine methyltransferase NDUFAF7 [IPR003788]", "Protein canopy homolog [IPR042415]", "Protein diaphanous homologue 2 [IPR027644]", "Protein disulfide-isomerase A6-like [IPR044569]", "Protein disulphide isomerase [IPR005792]", "Protein disulphide-isomerase A4 [IPR017068]", "Protein farnesyltransferase subunit beta [IPR026872]", "Protein flightless-1 [IPR029919]", "Protein import receptor MAS20 [IPR002056]", "Protein import receptor MAS20, metazoan [IPR022422]", "Protein kinase C and casein kinase substrate in neurons protein 2 [IPR028521]", "Protein kinase C, delta [IPR027436]", "Protein kinase C, delta/epsilon/eta/theta types [IPR014376]", "Protein kinase Mps1 family [IPR027084]", "Protein of unknown function DUF1075 [IPR009432]", "Protein of unknown function DUF2046 [IPR019152]", "Protein of unknown function DUF4615 [IPR029274]", "Protein of unknown function DUF4726 [IPR031714]", "Protein of unknown function DUF719 [IPR007998]", "Protein patched/dispatched [IPR003392]", "Protein phosphatase 2A regulatory subunit PR55 [IPR000009]", "Protein phosphatase 2A, regulatory B subunit, B56 [IPR002554]", "Protein phosphatase 2C family [IPR015655]", "Protein phosphatase methylesterase, eukaryotic [IPR016812]", "Protein spinster-like [IPR044770]", "Protein suppressor of sable-like [IPR045124]", "Protein translocase SEC61 complex, gamma subunit [IPR008158]", "Protein translocase complex, SecE/Sec61-gamma subunit [IPR001901]", "Protein transport Sec61-beta/Sbh [IPR030671]", "Protein transport protein Got1 [IPR045176]", "Protein transport protein SEC31-like [IPR040251]", "Protein transport protein Sec23 [IPR037364]", "Protein transport protein SecG/Sec61-beta/Sbh [IPR016482]", "Protein wntless [IPR009551]", "Protein-L-isoaspartate(D-aspartate) O-methyltransferase [IPR000682]", "Protein-S-isoprenylcysteine O-methyltransferase [IPR025770]", "Protein-glutamate O-methyltransferase [IPR039763]", "Protein-tyrosine phosphatase, low molecular weight [IPR017867]", "Protein-tyrosine phosphatase, low molecular weight, mammalian [IPR002115]", "Protein-tyrosine phosphatase, non-receptor type-1/2 [IPR012265]", "Protein-tyrosine phosphatase, non-receptor type-6, -11 [IPR012152]", "Protein-tyrosine phosphatase-like, PTPLA [IPR007482]", "Protein/nucleic acid deglycase DJ-1 [IPR006287]", "Proteinase inhibitor I25A, stefin [IPR001713]", "Pseudouridine synthase I, TruA [IPR001406]", "Pseudouridine synthase PUS1/ PUS2-like [IPR041708]", "Pseudouridine synthase, TruD [IPR001656]", "Pterin 4 alpha carbinolamine dehydratase [IPR001533]", "Pumilio homologue 3 [IPR040059]", "Purine 5'-nucleotidase [IPR016695]", "Purine nucleoside phosphorylase I, inosine/guanosine-specific [IPR011270]", "Purine nucleoside phosphorylase [IPR011268]", "Purine-rich element binding protein family [IPR006628]", "Purine-rich element-binding protein alpha [IPR030500]", "Putative peptidyl-tRNA hydrolase PTRHD1 [IPR042237]", "Pyridine nucleotide-disulphide oxidoreductase, class I [IPR001100]", "Pyridoxal phosphate-dependent decarboxylase [IPR002129]", "Pyridoxine kinase [IPR004625]", "Pyrimidine 5'-nucleotidase, eukaryotic [IPR006434]", "Pyrroline-5-carboxylate reductase [IPR000304]", "Pyruvate carboxylase [IPR005930]", "Pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit, subgroup y [IPR017597]", "Pyruvate dehydrogenase E1 component subunit beta [IPR027110]", "Pyruvate kinase [IPR001697]", "RAD3/XPD family [IPR001945]", "RINT-1/Tip20 [IPR007528]", "RLI1 [IPR013283]", "RNA (C5-cytosine) methyltransferase [IPR023267]", "RNA (C5-cytosine) methyltransferase, NOP2 [IPR023273]", "RNA 3'-terminal phosphate cyclase [IPR000228]", "RNA 3'-terminal phosphate cyclase type 2 [IPR016443]", "RNA binding protein HABP4/SERBP1 [IPR039764]", "RNA cytidine acetyltransferase NAT10 [IPR033688]", "RNA demethylase ALKBH5 [IPR032860]", "RNA exonuclease 4 [IPR034920]", "RNA polymerase I associated factor, A49-like [IPR009668]", "RNA polymerase II associated factor Paf1 [IPR007133]", "RNA polymerase II transcription factor SIII, subunit A [IPR010684]", "RNA polymerase II transcriptional coactivator Sub1/Tcp4-like [IPR045125]", "RNA polymerase II-associated protein RPAP1/Rba50 [IPR039913]", "RNA polymerase subunit Rpb7-like [IPR045113]", "RNA transcription, translation and transport factor protein [IPR019265]", "RNA-binding motif protein 8 [IPR008111]", "RNA-binding protein 10 [IPR033095]", "RNA-binding protein 26 [IPR034861]", "RNA-binding protein 26/27 [IPR045137]", "RNA-binding protein 5 [IPR033094]", "RNA-binding protein EWS [IPR033109]", "RNA-binding protein FUS [IPR034459]", "RNA-binding protein NOB1 [IPR039907]", "RNA-induced silencing complex, nuclease component Tudor-SN [IPR016685]", "RNA-splicing ligase RtcB homologue, eukaryotic [IPR027513]", "RNA-splicing ligase, RtcB [IPR001233]", "RNase P subunit p30 [IPR002738]", "RPA-related protein RADX [IPR040893]", "RZZ complex, subunit Zw10 [IPR009361]", "Rab GDI protein [IPR000806]", "Rab GTPase-activating protein 1 [IPR033185]", "Rab protein geranylgeranyltransferase component A [IPR001738]", "Rab-like protein 6 [IPR040385]", "Rab21 [IPR041833]", "Rab24 [IPR041828]", "Rab35 [IPR041815]", "Rab3GAP regulatory subunit [IPR026059]", "Rad21/Rec8-like protein [IPR039781]", "RalBP1-associated Eps domain-containing protein 1 [IPR026814]", "Ran GTPase [IPR002041]", "Ran binding protein RanBP1-like [IPR045255]", "Ran-interacting Mog1 protein [IPR007681]", "Rap guanine nucleotide exchange factor 2 [IPR030739]", "Ras GTPase GNL1-like [IPR043358]", "Ras GTPase-activating protein-binding protein 1 [IPR034375]", "Ras GTPase-activating protein-binding protein 2 [IPR034377]", "Ras GTPase-activating protein-binding protein [IPR039539]", "Ras-like guanine nucleotide exchange factor [IPR008937]", "Ras-related protein Rab-23 [IPR034114]", "Ras-related protein Rab14 [IPR030702]", "Ras-related protein Ral [IPR028412]", "Ras-related protein Rap2 [IPR041840]", "Regulator of MON1-CCZ1 complex [IPR040371]", "Remodeling and spacing factor 1-like [IPR028938]", "Remodelling complex subunit Rsc/polybromo [IPR037382]", "Renin receptor-like [IPR012493]", "Replication factor A protein 1 [IPR004591]", "Replication factor A protein 2 [IPR014646]", "Replication factor A protein-like [IPR040260]", "Replication factor C subunit 1 [IPR012178]", "Replication termination factor 2 [IPR006735]", "Retinal rod rhodopsin-sensitive cGMP 3', 5'-cyclic phosphodiesterase, delta subunit [IPR017287]", "Retinoblastoma protein family [IPR028309]", "Retrieval of early ER protein Rer1 [IPR004932]", "Rho GDP/GTP exchange factor Kalirin/TRIO [IPR028570]", "Rho protein GDP-dissociation inhibitor [IPR000406]", "Rho-associated protein kinase 1/2 [IPR020684]", "Ribonuclease CAF1 [IPR006941]", "Ribonuclease H2, subunit A [IPR004649]", "Ribonuclease HII/HIII [IPR001352]", "Ribonuclease III [IPR011907]", "Ribonuclease Nob1, eukaryote [IPR017117]", "Ribonuclease T2, eukaryotic [IPR033697]", "Ribonuclease T2-like [IPR001568]", "Ribonucleases P/MRP protein subunit Pop1 [IPR039182]", "Ribonucleoprotein PTB-binding 1 [IPR034635]", "Ribonucleoside-diphosphate reductase large subunit [IPR039718]", "Ribonucleotide reductase small subunit [IPR033909]", "Ribonucleotide reductase small subunit family [IPR000358]", "Ribophorin I [IPR007676]", "Ribose-phosphate pyrophosphokinase [IPR005946]", "Ribose-phosphate pyrophosphokinase, bacterial-type [IPR037515]", "Ribosomal RNA adenine dimethylase [IPR011530]", "Ribosomal RNA adenine methyltransferase KsgA/Erm [IPR001737]", "Ribosomal RNA assembly KRR1 [IPR024166]", "Ribosomal RNA large subunit methyltransferase E [IPR015507]", "Ribosomal RNA processing protein 8 [IPR007823]", "Ribosomal RNA-processing protein 15 [IPR012459]", "Ribosomal biogenesis NSA2 family [IPR039411]", "Ribosomal biogenesis regulatory protein [IPR007023]", "Ribosomal biogenesis, methyltransferase, EMG1/NEP1 [IPR005304]", "Ribosomal export protein Nmd3 [IPR039768]", "Ribosomal protein L1 [IPR002143]", "Ribosomal protein L1, mitochondrial [IPR005879]", "Ribosomal protein L1/ribosomal biogenesis protein [IPR028364]", "Ribosomal protein L10P [IPR001790]", "Ribosomal protein L10e [IPR001197]", "Ribosomal protein L11, bacterial-type [IPR006519]", "Ribosomal protein L11/L12 [IPR000911]", "Ribosomal protein L12/P1/P2 family [IPR027534]", "Ribosomal protein L13 [IPR005822]", "Ribosomal protein L13, eukaryotic/archaeal [IPR005755]", "Ribosomal protein L13e [IPR001380]", "Ribosomal protein L14 [IPR039660]", "Ribosomal protein L14P [IPR000218]", "Ribosomal protein L15 [IPR030878]", "Ribosomal protein L15, bacterial-type [IPR005749]", "Ribosomal protein L15e [IPR000439]", "Ribosomal protein L18e [IPR000039]", "Ribosomal protein L19 [IPR001857]", "Ribosomal protein L2 [IPR002171]", "Ribosomal protein L2, archaeal-type [IPR023672]", "Ribosomal protein L21 [IPR001787]", "Ribosomal protein L21-like [IPR028909]", "Ribosomal protein L21e [IPR001147]", "Ribosomal protein L22/L17 [IPR001063]", "Ribosomal protein L22/L17, eukaryotic/archaeal [IPR005721]", "Ribosomal protein L22e [IPR002671]", "Ribosomal protein L23 [IPR019985]", "Ribosomal protein L24e [IPR023438]", "Ribosomal protein L24e-related [IPR000988]", "Ribosomal protein L25/L23 [IPR013025]", "Ribosomal protein L26/L24, eukaryotic/archaeal [IPR005756]", "Ribosomal protein L27e [IPR001141]", "Ribosomal protein L28/L24 [IPR026569]", "Ribosomal protein L28/L40, mitochondrial [IPR019192]", "Ribosomal protein L28e [IPR002672]", "Ribosomal protein L29/L35 [IPR001854]", "Ribosomal protein L29e [IPR002673]", "Ribosomal protein L3 [IPR000597]", "Ribosomal protein L3, archaeal/eukaryotic type [IPR045077]", "Ribosomal protein L3, bacterial/organelle-type [IPR019927]", "Ribosomal protein L30/YlxQ [IPR039109]", "Ribosomal protein L30e [IPR000231]", "Ribosomal protein L31e [IPR000054]", "Ribosomal protein L32e [IPR001515]", "Ribosomal protein L34Ae [IPR008195]", "Ribosomal protein L35A [IPR001780]", "Ribosomal protein L36e [IPR000509]", "Ribosomal protein L37/S30 [IPR010793]", "Ribosomal protein L37ae [IPR002674]", "Ribosomal protein L37e [IPR001569]", "Ribosomal protein L38e [IPR002675]", "Ribosomal protein L4, eukaryotic and archaeal type [IPR045240]", "Ribosomal protein L4/L1e [IPR002136]", "Ribosomal protein L44e [IPR000552]", "Ribosomal protein L47, mitochondrial [IPR010729]", "Ribosomal protein L49/IMG2 [IPR007740]", "Ribosomal protein L5 [IPR002132]", "Ribosomal protein L5 eukaryotic/L18 archaeal [IPR005485]", "Ribosomal protein L50, mitochondria [IPR018305]", "Ribosomal protein L53, mitochondrial [IPR019716]", "Ribosomal protein L6 [IPR000702]", "Ribosomal protein L7, eukaryotic [IPR005998]", "Ribosomal protein L7/L12 [IPR000206]", "Ribosomal protein L7/L30 [IPR039699]", "Ribosomal protein L7A/L8 [IPR001921]", "Ribosomal protein L7Ae/L8/Nhp2 family [IPR018492]", "Ribosomal protein L9 [IPR000244]", "Ribosomal protein P2 [IPR044076]", "Ribosomal protein S10 [IPR001848]", "Ribosomal protein S10, eukaryotic/archaeal [IPR005729]", "Ribosomal protein S11 [IPR001971]", "Ribosomal protein S12/S23 [IPR006032]", "Ribosomal protein S12e [IPR000530]", "Ribosomal protein S13 [IPR001892]", "Ribosomal protein S15 [IPR000589]", "Ribosomal protein S15P [IPR023029]", "Ribosomal protein S17, archaeal/eukaryotic [IPR028333]", "Ribosomal protein S17/S11 [IPR000266]", "Ribosomal protein S17e [IPR001210]", "Ribosomal protein S19e [IPR001266]", "Ribosomal protein S2 [IPR001865]", "Ribosomal protein S2, bacteria/mitochondria/plastid [IPR005706]", "Ribosomal protein S2, eukaryotic [IPR027498]", "Ribosomal protein S2, eukaryotic/archaeal [IPR005707]", "Ribosomal protein S21e [IPR001931]", "Ribosomal protein S22, mitochondrial [IPR019374]", "Ribosomal protein S23, eukaryotic/archaeal [IPR005680]", "Ribosomal protein S23, mitochondrial [IPR019520]", "Ribosomal protein S23/S29, mitochondrial [IPR019368]", "Ribosomal protein S24/S35, mitochondrial [IPR039848]", "Ribosomal protein S24e [IPR001976]", "Ribosomal protein S25 [IPR004977]", "Ribosomal protein S27/S33, mitochondrial [IPR013219]", "Ribosomal protein S28, mitochondrial [IPR019375]", "Ribosomal protein S29, mitochondrial [IPR008092]", "Ribosomal protein S3, eukaryotic/archaeal [IPR005703]", "Ribosomal protein S30 [IPR006846]", "Ribosomal protein S30, mitochondrial [IPR039982]", "Ribosomal protein S3Ae [IPR001593]", "Ribosomal protein S4/S9 [IPR022801]", "Ribosomal protein S4/S9, eukaryotic/archaeal [IPR005710]", "Ribosomal protein S4e [IPR000876]", "Ribosomal protein S5 [IPR000851]", "Ribosomal protein S5, eukaryotic/archaeal [IPR005711]", "Ribosomal protein S5/S7 [IPR000235]", "Ribosomal protein S5/S7, eukaryotic/archaeal [IPR005716]", "Ribosomal protein S6 kinase II [IPR016239]", "Ribosomal protein S6, eukaryotic [IPR014401]", "Ribosomal protein S6e [IPR001377]", "Ribosomal protein S7e [IPR000554]", "Ribosomal protein S8 [IPR000630]", "Ribosomal protein S8e [IPR001047]", "Ribosomal protein S8e/ribosomal biogenesis NSA2 [IPR022309]", "Ribosomal protein S9 [IPR000754]", "Ribosome assembly factor Mrt4 [IPR033867]", "Ribosome biogenesis protein BRX1 [IPR026532]", "Ribosome biogenesis protein Bms1/Tsr1 [IPR039761]", "Ribosome biogenesis protein Nop53/GLTSCR2 [IPR011687]", "Ribosome biogenesis protein Rpf2 [IPR039770]", "Ribosome maturation protein Sdo1/SBDS [IPR002140]", "Ribosome maturation protein Sdo1/SBDS-like [IPR039100]", "Ribosome-binding ATPase YchF/Obg-like ATPase 1 [IPR004396]", "Ribosome-binding protein 1 [IPR040248]", "RidA family [IPR006056]", "RuvB-like [IPR027238]", "RuvB-like helicase 1 [IPR037938]", "RuvB-like helicase 2 [IPR037942]", "S-adenosylmethionine synthetase [IPR002133]", "S-formylglutathione hydrolase [IPR014186]", "S-phase kinase-associated protein 1 [IPR016897]", "S-phase kinase-associated protein 1-like [IPR001232]", "SAP30-binding protein [IPR012479]", "SCAMP [IPR007273]", "SERRATE/Ars2 [IPR039727]", "SH3 and PX domain-containing protein 2B [IPR030512]", "SH3-binding, glutamic acid-rich protein [IPR006993]", "SHC SH2 domain-binding protein 1-like [IPR045140]", "SKI-interacting protein, SKIP [IPR017862]", "SLC12A transporter family [IPR004842]", "SNF5/SMARCB1/INI1 [IPR006939]", "SNU66/SART1 family [IPR005011]", "SNX17/27/31 [IPR037831]", "SOS response associated peptidase (SRAP) [IPR003738]", "SOUL haem-binding protein [IPR006917]", "SPIN90/Ldb17 [IPR030125]", "SSNA1 family [IPR033362]", "STEEP-like [IPR029704]", "SUMO-activating enzyme subunit Uba2 [IPR030661]", "SUN domain-containing protein 1 [IPR018539]", "SUN domain-containing protein 1-5 [IPR045119]", "SURP and G-patch domain-containing protein 1/2 [IPR040169]", "SWI/SNF complex subunit BAF57 [IPR030089]", "SWI/SNF complex subunit BRG1 [IPR030100]", "SWI/SNF complex subunit SMARCC1 [IPR030087]", "SWI/SNF complex subunit SMARCC2 [IPR038044]", "SWI/SNF-like complex subunit BAF250a [IPR030094]", "SWI/SNF-like complex subunit BAF250/Osa [IPR021906]", "Saposin [IPR008373]", "Saposin, chordata [IPR021165]", "Scaffold attachment factor B1 [IPR034781]", "Scaffold attachment factor B2 [IPR034782]", "Scavenger mRNA decapping enzyme DcpS/DCS2 [IPR008594]", "Scc2/Nipped-B family [IPR033031]", "Schlafen family [IPR029684]", "Sdc1/DPY30 [IPR037856]", "Sec1-like protein [IPR001619]", "Sec13/Seh1 family [IPR037363]", "SecY/SEC61-alpha family [IPR002208]", "Selenophosphate synthetase [IPR004536]", "Sentrin-specific protease 3 [IPR037945]", "Sepiapterin reductase [IPR006393]", "Septin 2 [IPR008113]", "Septin 7 [IPR008115]", "Septin 9 [IPR030645]", "Septin [IPR016491]", "Serine hydroxymethyltransferase [IPR001085]", "Serine-tRNA ligase, type1 [IPR002317]", "Serine/arginine-rich splicing factor 10 [IPR034476]", "Serine/arginine-rich splicing factor 11 [IPR034447]", "Serine/arginine-rich splicing factor 2-like [IPR034893]", "Serine/arginine-rich splicing factor 6 [IPR029541]", "Serine/threonine protein phosphatase 5 [IPR011236]", "Serine/threonine-protein kinase OSR1 [IPR028749]", "Serine/threonine-protein kinase PAK2 [IPR035065]", "Serine/threonine-protein kinase TOR [IPR026683]", "Serine/threonine-protein kinase Vps15-like [IPR045162]", "Serine/threonine-protein phosphatase 2A subunit A, metazoa [IPR031090]", "Serine/threonine-protein phosphatase 4 regulatory subunit 1 [IPR031087]", "Serine/threonine-protein phosphatase PP1-alpha catalytic subunit [IPR037979]", "Serpin H1 [IPR033547]", "Serpin family [IPR000215]", "Short transmembrane mitochondrial protein 1 [IPR027854]", "Short-chain dehydrogenase/reductase SDR [IPR002347]", "Sideroflexin-4 [IPR028825]", "Sigma intracellular receptor 2 [IPR016964]", "Signal peptidase complex catalytic subunit SEC11A [IPR037712]", "Signal peptidase complex subunit Spc2/SPCS2 [IPR009582]", "Signal recognition particle SRP9 [IPR039914]", "Signal recognition particle receptor, beta subunit [IPR019009]", "Signal recognition particle subunit SRP68 [IPR026258]", "Signal recognition particle, SRP14 subunit [IPR003210]", "Signal recognition particle, SRP54 subunit [IPR022941]", "Signal recognition particle, SRP54 subunit, eukaryotic [IPR006325]", "Signal recognition particle, SRP72 subunit [IPR026270]", "Signal recognition particle, SRP9 subunit [IPR008832]", "Sin3 associated polypeptide p18 [IPR010516]", "Single-stranded DNA-binding protein [IPR011344]", "Sister chromatid cohesion protein Pds5 [IPR039776]", "Ski3/TTC37 [IPR039226]", "Sm-like protein Lsm6/SmF [IPR016487]", "Sm-like protein Lsm7 [IPR017132]", "Sm-like protein Lsm7/SmG [IPR044641]", "Smac/DIABLO protein [IPR015142]", "Small (40S) ribosomal subunit Asc1/RACK1 [IPR045223]", "Small GTPase Rho [IPR003578]", "Small GTPase [IPR001806]", "Small GTPase superfamily, ARF type [IPR024156]", "Small GTPase superfamily, ARF/SAR type [IPR006689]", "Small GTPase superfamily, SAR1-type [IPR006687]", "Small GTPase, Ras-type [IPR020849]", "Small nuclear ribonucleoprotein E [IPR027078]", "Small nuclear ribonucleoprotein Sm D2 [IPR027248]", "Small nuclear ribonucleoprotein Sm D3 [IPR034099]", "Small-subunit processome, Utp14 [IPR006709]", "Smooth muscle protein/calponin [IPR003096]", "Snf7 family [IPR005024]", "Sodium/potassium-transporting ATPase subunit beta [IPR000402]", "Sodium/potassium-transporting ATPase subunit beta, chordates [IPR015565]", "Sodium:dicarboxylate symporter [IPR001991]", "Solute carrier family 12 member 1/2 [IPR002443]", "Solute carrier family 12 member 2 [IPR002444]", "Solute carrier family 12 member 9 [IPR030345]", "Solute carrier family 25 member 44 [IPR042164]", "Solute carrier family 35 member SLC35F1/F2/F6 [IPR009262]", "Sorting nexin 9 family [IPR014536]", "Sorting nexin-1 [IPR028660]", "Sorting nexin-2 [IPR028653]", "Sorting nexin-27 [IPR028667]", "Sorting nexin-5 [IPR028654]", "Sorting nexin-5/6/32 [IPR014637]", "Sorting nexin-6 [IPR028657]", "Sorting nexin-9 [IPR028644]", "Spartin-like [IPR045036]", "Spectrin, beta subunit [IPR016343]", "Spermatid perinuclear RNA-binding protein [IPR030446]", "Spermidine/spermine synthase, eukaryotes [IPR030668]", "Spermidine/spermine synthases [IPR001045]", "Sphingomyelin phosphodiesterase 4 [IPR024129]", "Sphingosine N-acyltransferase Lag1/Lac1-like [IPR016439]", "Splicing factor 3A subunit 1 [IPR045146]", "Splicing factor 3A subunit 3 [IPR031776]", "Splicing factor 3B subunit 1-like [IPR038737]", "Splicing factor 45 [IPR040052]", "Splicing factor ELAV/Hu [IPR006548]", "Splicing factor, RBM39-like [IPR006509]", "Squalene cyclase [IPR018333]", "Squalene monooxygenase [IPR040125]", "Squalene synthase-like [IPR006449]", "Squalene/phytoene synthase [IPR002060]", "Stathmin family [IPR000956]", "Steroidogenic acute regulatory protein-like [IPR000799]", "Sterol transport protein NPC2-like [IPR039670]", "Stomatin [IPR028515]", "Stomatin/HflK/HflC family [IPR001972]", "Structural maintenance of chromosomes flexible hinge domain-containing protein 1 [IPR038892]", "Structural maintenance of chromosomes protein 1A, metazoan [IPR029683]", "Structural maintenance of chromosomes protein [IPR024704]", "Structure-specific recognition protein [IPR000969]", "Succinate dehydrogenase, flavoprotein subunit [IPR011281]", "Succinate dehydrogenase/fumarate reductase iron-sulphur protein [IPR004489]", "Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [IPR014006]", "Succinate semialdehyde dehydrogenase [IPR010102]", "Succinate--CoA synthetase, beta subunit [IPR005809]", "Succinyl-CoA ligase, alpha subunit [IPR005810]", "Sulfhydryl oxidase [IPR039798]", "Sulfotransferase [IPR005331]", "Sulfurtransferase TST/MPST-like [IPR045078]", "Suppressor of white apricot [IPR040397]", "Surface antigen D15-like [IPR039910]", "Surfeit locus 1/4 [IPR045214]", "Surfeit locus 4 [IPR002995]", "Surfeit locus 6 [IPR007019]", "Symplekin/Pta1 [IPR021850]", "Synaptobrevin [IPR001388]", "Synaptogyrin [IPR016579]", "Syntaxin [IPR045242]", "Syntenin-1 [IPR030528]", "Synthesis of cytochrome c oxidase, Sco1/Sco2 [IPR017276]", "T-complex protein 1, alpha subunit [IPR012715]", "T-complex protein 1, beta subunit [IPR012716]", "T-complex protein 1, delta subunit [IPR012717]", "T-complex protein 1, epsilon subunit [IPR012718]", "T-complex protein 1, eta subunit [IPR012720]", "T-complex protein 1, gamma subunit [IPR012719]", "T-complex protein 1, theta subunit [IPR012721]", "T-complex protein 1, zeta subunit [IPR012722]", "TACC family [IPR039915]", "TAF15/EWS/TLS family [IPR034870]", "TAP46-like protein [IPR007304]", "TATA binding associated factor 15 [IPR034875]", "TATA-binding protein-associated factor Mot1 [IPR044972]", "TB2/DP1/HVA22-related protein [IPR004345]", "TE2IP/Rap1 [IPR039595]", "TH1 protein [IPR006942]", "THO complex subunit 2 [IPR040007]", "THO complex subunit 6 [IPR042626]", "THO complex, subunit THOC1 [IPR021861]", "THRAP3/BCLAF1 family [IPR029199]", "THUMP domain-containing protein 1-like [IPR040183]", "TIP41-like protein [IPR007303]", "TMEM14 family [IPR005349]", "TMEM192 family [IPR029399]", "TMEM33/Pom33 family [IPR005344]", "TNF receptor-associated factor 2 [IPR027133]", "TNF receptor-associated factor TRAF [IPR043211]", "TNF receptor-associated factor TRAF, metazoa [IPR012227]", "TOX high mobility group box family member 4 [IPR037985]", "TPP-binding domain containing protein HACL1-like [IPR045025]", "TPX2 [IPR009675]", "TRAPP I complex, subunit 5 [IPR016696]", "TREX component Tex1/THOC3 [IPR040132]", "Target of Myb protein 1 [IPR014645]", "Taxilin family [IPR026183]", "Telomere-associated protein Rif1 [IPR028566]", "Testis-expressed protein 10/pre-rRNA-processing protein Ipi1 [IPR037947]", "Tetrahydrofolate dehydrogenase/cyclohydrolase [IPR000672]", "Tetraspanin, animals [IPR000301]", "Tetraspanin/Peripherin [IPR018499]", "Tetratricopeptide repeat protein 19 [IPR040395]", "Tetratricopeptide repeat protein 26 [IPR030511]", "Tetratricopeptide repeat protein 38 [IPR033891]", "The WD repeat Cdc20/Fizzy family [IPR033010]", "ThiF/MoeB/HesA family [IPR045886]", "Thiamine pyrophosphate enzyme [IPR045229]", "Thiolase [IPR002155]", "Thioredoxin domain-containing protein 17-like [IPR045108]", "Thioredoxin-related transmembrane protein 2 [IPR039101]", "Thioredoxin/glutathione reductase selenoprotein [IPR006338]", "Threonine-tRNA ligase, class IIa [IPR002320]", "Thymidine kinase [IPR001267]", "Thymidylate kinase [IPR018094]", "Thymidylate synthase [IPR000398]", "Thymidylate synthase/dCMP hydroxymethylase [IPR045097]", "Thyroid hormone receptor-associated protein 3 [IPR026667]", "Tight junction protein ZO [IPR005417]", "Tight junction protein ZO-1 [IPR005418]", "Tim23-like [IPR045238]", "Tim44-like [IPR039544]", "Tissue alpha-L-fucosidase [IPR028755]", "TmcA/NAT10/Kre33 [IPR032672]", "Tom40 [IPR037930]", "Torsin-1A-interacting protein 1/2 [IPR008662]", "TraB/PrgY/GumN family [IPR002816]", "Trafficking protein particle complex subunit [IPR007233]", "Trans-isoprenyl diphosphate synthases, eukaryotic-type [IPR044844]", "Transaldolase type 1 [IPR004730]", "Transaldolase/Fructose-6-phosphate aldolase [IPR001585]", "Transcription elongation factor SPT5 [IPR039659]", "Transcription elongation factor Spt5, eukaryote [IPR017071]", "Transcription elongation factor Spt6 [IPR017072]", "Transcription elongation factor, IIS-type [IPR035100]", "Transcription elongation factor, TFIIS [IPR006289]", "Transcription elongation regulator 1-like [IPR045148]", "Transcription facto Tfc3-like [IPR044210]", "Transcription factor BTF3 [IPR039370]", "Transcription factor II-I [IPR016659]", "Transcription factor RelA (p65) [IPR030495]", "Transcription factor STAT [IPR001217]", "Transcription factor Tfc4/TFIIIC-102/Sfc4 [IPR039340]", "Transcription initiation factor TFIID subunit 6 [IPR037796]", "Transcription intermediary factor 1-beta [IPR037373]", "Transcriptional regulator TACO1-like [IPR002876]", "Transcriptional regulatory protein Sin3-like [IPR039774]", "Transcriptional regulatory protein Sin3a [IPR037969]", "Transcriptional repressor p66 [IPR040386]", "Transducin beta-like protein 2 [IPR042410]", "Transferrin receptor protein 1 [IPR029513]", "Transgelin-2 [IPR001061]", "Translation Initiation factor eIF- 4e [IPR001040]", "Translation elongation factor EF1A, eukaryotic/archaeal [IPR004539]", "Translation elongation factor EFG/EF2 [IPR004540]", "Translation elongation factor EFTs/EF1B [IPR001816]", "Translation elongation factor EFTu/EF1A, bacterial/organelle [IPR004541]", "Translation elongation factor IF5A-like [IPR001884]", "Translation initiation factor 2, alpha subunit [IPR011488]", "Translation initiation factor 2A [IPR011387]", "Translation initiation factor 3 complex subunit L [IPR019382]", "Translation initiation factor IF- 2 [IPR015760]", "Translation initiation factor IF2/IF5 [IPR045196]", "Translation machinery associated TMA7 [IPR015157]", "Translation release factor pelota [IPR004405]", "Translational activator Gcn1 [IPR033173]", "Translationally controlled tumour protein [IPR018105]", "Translin [IPR033956]", "Translin family [IPR002848]", "Translocation associated membrane protein [IPR016447]", "Translocation protein Sec62 [IPR004728]", "Translocation protein Sec63 [IPR027137]", "Translocator protein [IPR030164]", "Translocon-associated [IPR008855]", "Translocon-associated protein (TRAP), alpha subunit [IPR005595]", "Transmembrane emp24 domain-containing protein 5 [IPR015717]", "Transmembrane emp24 domain-containing protein 7 [IPR015718]", "Transmembrane emp24 domain-containing protein [IPR015720]", "Transmembrane protein 109 [IPR039492]", "Transmembrane protein 11 [IPR026120]", "Transmembrane protein 126 [IPR009801]", "Transmembrane protein 160 [IPR026801]", "Transmembrane protein 205 [IPR042623]", "Transmembrane protein 214 [IPR019308]", "Transmembrane protein 230 [IPR044234]", "Transmembrane protein 230/134 [IPR008590]", "Transmembrane protein 43 family [IPR012430]", "Transmembrane protein 65 [IPR019537]", "Transmembrane protein GPR107/GPR108-like [IPR009637]", "Transport protein particle (TRAPP) component [IPR007194]", "Treacle protein [IPR017859]", "Tricarboxylate/iron carrier [IPR004686]", "Triosephosphate isomerase [IPR000652]", "Triosephosphate isomerase, bacterial/eukaryotic [IPR022896]", "Tropomodulin [IPR004934]", "Tropomodulin-3 [IPR030133]", "Tropomyosin [IPR000533]", "Tryptophan-tRNA ligase [IPR002306]", "TspO/MBR-related protein [IPR004307]", "Tubulin [IPR000217]", "Tubulin binding cofactor A [IPR004226]", "Tubulin--tyrosine ligase-like protein 12 [IPR027749]", "Tubulin-folding cofactor D [IPR033162]", "Tubulin-specific chaperone E [IPR044994]", "Tubulin-tyrosine ligase/Tubulin polyglutamylase [IPR004344]", "Tumour protein D52 [IPR007327]", "Tweety [IPR006990]", "Twinfilin [IPR028458]", "Type 1 protein exporter [IPR039421]", "Type II pantothenate kinase [IPR004567]", "Tyrosine-tRNA ligase [IPR002307]", "Tyrosine-tRNA ligase, bacterial-type [IPR024088]", "Tyrosine/threonine-protein kinase, Cdc2 inhibitor [IPR016235]", "U1 small nuclear ribonucleoprotein C [IPR017340]", "U2 small nuclear ribonucleoprotein A' [IPR044640]", "U2 snRNP auxilliary factor, large subunit, splicing factor [IPR006529]", "U3 small nucleolar RNA-associated protein 10 [IPR040191]", "U3 small nucleolar RNA-associated protein 18 [IPR045161]", "U3 small nucleolar RNA-associated protein 25 [IPR010678]", "U3 small nucleolar RNA-associated protein 6 [IPR013949]", "U3 small nucleolar ribonucleoprotein complex, subunit Mpp10 [IPR012173]", "U3 snoRNP protein/Ribosome production factor 1 [IPR044281]", "U4/U6 small nuclear ribonucleoprotein Prp3 [IPR027104]", "U4/U6 small nuclear ribonucleoprotein Prp31 [IPR027105]", "U6 snRNA-associated Sm-like protein LSm2 [IPR016654]", "UAA transporter [IPR013657]", "UBAP2/protein lingerer [IPR022166]", "UBX domain-containing protein 2/7 [IPR017346]", "UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110kDa subunit [IPR037919]", "UDP-glucose 6-dehydrogenase, eukaryotic type [IPR028356]", "UDP-glucose/GDP-mannose dehydrogenase [IPR017476]", "UDP-glucose:Glycoprotein Glucosyltransferase [IPR009448]", "UDP-sugar pyrophosphorylase [IPR039741]", "UDPGP family [IPR002618]", "UHRF1/2-like [IPR045134]", "UMP-CMP kinase [IPR006266]", "UPF0600 protein C5orf51 [IPR037657]", "USP39 [IPR033809]", "UTP--glucose-1-phosphate uridylyltransferase [IPR016267]", "UV excision repair protein Rad23 [IPR004806]", "Ubiquinol-cytochrome-c reductase complex assembly factor 2 [IPR037698]", "Ubiquinone biosynthesis O-methyltransferase [IPR010233]", "Ubiquinone biosynthesis protein COQ9 [IPR012762]", "Ubiquitin carboxyl-terminal hydrolase 10 [IPR028767]", "Ubiquitin carboxyl-terminal hydrolase 14-like [IPR044635]", "Ubiquitin conjugation factor E4 [IPR045132]", "Ubiquitin fusion degradation protein Ufd1-like [IPR004854]", "Ubiquitin thioesterase OTUB1 [IPR030298]", "Ubiquitin thioesterase Otubain [IPR016615]", "Ubiquitin thioesterase otulin [IPR023237]", "Ubiquitin-activating enzyme E1 [IPR018075]", "Ubiquitin-fold modifier-conjugating enzyme 1 [IPR014806]", "Ubiquitin-like-conjugating enzyme Atg3/Atg10 [IPR007135]", "Ubiquitin-protein ligase E3B/C [IPR044611]", "Ubiquitin-specific peptidase 24 [IPR033382]", "Ubiquitin/SUMO-activating enzyme E1 [IPR000011]", "Ubiquitinyl hydrolase [IPR016652]", "Ubiquitinyl hydrolase, UCH37 type [IPR017390]", "Uncharacterized protein KIAA2013-like [IPR018795]", "Uridine kinase-like [IPR000764]", "Uridine-cytidine kinase 2 [IPR029925]", "Uroporphyrinogen decarboxylase HemE [IPR006361]", "V-type ATPase, V0 complex, 116kDa subunit family [IPR002490]", "V-type ATP synthase catalytic alpha chain [IPR022878]", "V-type ATP synthase regulatory subunit B/beta [IPR022879]", "V-type ATPase subunit E [IPR002842]", "V0 complex accessory subunit Ac45 [IPR008388]", "VPRBP/DCAF1 family [IPR033270]", "Vacuolar (H+)-ATPase G subunit [IPR005124]", "Vacuolar protein sorting protein 26 related [IPR028934]", "Vacuolar protein sorting-associated protein 16 [IPR016534]", "Vacuolar protein sorting-associated protein 29 [IPR028661]", "Vacuolar protein sorting-associated protein 33 [IPR027121]", "Vacuolar protein sorting-associated protein 35 [IPR005378]", "Vacuolar protein sorting-associated protein 4 [IPR031255]", "Vacuolar protein sorting-associated protein 51 [IPR014812]", "Vacuolar protein sorting-associated protein 53 [IPR039766]", "Vacuolar protein sorting-associated protein 9-like [IPR045046]", "Vacuolar protein sorting-associated protein Ist1 [IPR005061]", "Vacuolar protein-sorting protein Bro1-like [IPR045251]", "Valine-tRNA ligase [IPR002303]", "Vang-like protein [IPR009539]", "Vesicle transport protein, Got1/SFT2-like [IPR007305]", "Vesicle-associated membrane-protein-associated protein [IPR016763]", "Vesicle-fusing ATPase [IPR039812]", "Vesicle-trafficking protein Sec22 [IPR044565]", "Villin/Gelsolin [IPR007122]", "Vimentin [IPR027699]", "Vinculin [IPR017997]", "Vinculin/alpha-catenin [IPR006077]", "Vitamin K epoxide reductase complex subunit 1 [IPR042406]", "Vitamin K-dependent gamma-carboxylase [IPR007782]", "Voltage-dependent anion-selective channel protein 1 [IPR030270]", "Voltage-dependent anion-selective channel protein 2 [IPR030277]", "Voltage-dependent anion-selective channel protein 3 [IPR030271]", "WD repeat BOP1/Erb1 [IPR028598]", "WD repeat Prp46/PLRG1-like [IPR045241]", "WD repeat WDR12/Ytm1 [IPR028599]", "WD repeat domain phosphoinositide-interacting protein 2 [IPR032911]", "WD repeat-containing protein 41 [IPR040102]", "WD repeat-containing protein 91 [IPR039724]", "WD repeat-containing protein DCAF7-like [IPR045159]", "WD repeat-containing protein WDR18/Ipi3/RID3 [IPR045227]", "WD40 repeat-containing protein SMU1 [IPR045184]", "WW domain binding protein 11 [IPR019007]", "Wings apart-like protein [IPR039874]", "Wolframin [IPR026208]", "Wolframin family [IPR026209]", "XMAP215 family [IPR045110]", "XPG/Rad2 endonuclease [IPR006084]", "Xaa-Arg dipeptidase [IPR017144]", "YAP-binding/ALF4/Glomulin [IPR013877]", "YLP motif-containing protein 1 [IPR026314]", "YTH domain containing protein [IPR045168]", "YjeF N-terminal domain-containing protein NAXE-like [IPR032976]", "YjgF/YER057c/UK114 family [IPR006175]", "ZPR1 family [IPR040141]", "Zinc finger CCHC domain-containing protein 3 [IPR042509]", "Zinc finger FYVE domain containing protein, SARA/endofin [IPR035438]", "Zinc finger FYVE domain-containing protein, endofin [IPR017165]", "Zinc finger protein 638 [IPR033096]", "Zinc transporter Msc2-like [IPR045316]", "cAMP-dependent protein kinase regulatory subunit [IPR012198]", "dCTP pyrophosphatase 1 [IPR025984]", "dTDP-4-dehydrorhamnose reductase family [IPR005913]", "hnRNP A2/B1 [IPR034489]", "mRNA 3'-end-processing protein Rna14-like [IPR045243]", "mRNA export factor Gle2/RAE1 [IPR037631]", "p53 and DNA damage-regulated protein 1 [IPR030482]", "p53 tumour suppressor family [IPR002117]", "rRNA biogenesis protein Rrp5 [IPR045209]", "tRNA (C5-cytosine) methyltransferase, NCL1 [IPR023270]", "tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 [IPR017423]", "tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit [IPR028884]", "tRNA (guanine-N1-)-methyltransferase, eukaryotic [IPR007356]", "tRNA N6-adenosine threonylcarbamoyltransferase Kae1, archaea and eukaryote [IPR034680]", "tRNA methyltransferase 10 homologue C [IPR025812]", "tRNA methyltransferase, Trm1 [IPR002905]", "tRNA modification GTPase MnmE [IPR004520]", "tRNA pseudouridine synthase B family [IPR004802]", "tRNA pseudouridine synthase II, TruB [IPR014780]"], "available_proteins": ["AAAS", "AARS", "AARS2", "AATF", "ABCB1", "ABCB7", "ABCD3", "ABCE1", "ABHD12", "ABHD6", "ABI1", "ABRAXAS2", "ACAA2", "ACADM", "ACAT1", "ACAT2", "ACLY", "ACO2", "ACOT13", "ACOT7", "ACOX1", "ACOX3", "ACP1", "ACP2", "ACP6", "ACSL1", "ACTL6A", "ACTR1A", "ACTR2", "ACTR3", "ADD1", "ADD3", "ADH5", "ADI1", "ADK", "ADNP", "ADPGK", "ADPRHL2", "ADRM1", "ADSL", "ADSS", "AFG3L2", "AGL", "AGPS", "AHCY", "AHCYL1", "AHSA1", "AIMP2", "AIP", "AK1", "AK2", "AK3", "AKAP12", "AKAP13", "AKAP17A", "AKAP8", "AKAP8L", "AKR1A1", "AKR1B1", "ALDH16A1", "ALDH18A1", "ALDH3A2", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDOA", "ALDOC", "ALG1", "ALG12", "ALKBH5", "AMOT", "ANAPC1", "ANAPC10", "ANAPC5", "ANKLE2", "ANO10", "ANP32A", "ANP32B", "ANXA1", "ANXA11", "ANXA2", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP1M1", "AP1S2", "AP2A1", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "APEX1", "APEX2", "API5", "APLP2", "APOL2", "APOO", "APOOL", "APP", "APRT", "AQR", "ARCN1", "ARF4", "ARFIP1", "ARFIP2", "ARHGDIA", "ARID1A", "ARID3B", "ARIH1", "ARIH2", "ARL1", "ARL10", "ARL2", "ARL3", "ARL6IP1", "ARL6IP5", "ARMC6", "ARMT1", "ARPC1A", "ARPC2", "ARPC3", "ARPC4", "ARV1", "ASAH1", "ASH2L", "ASNA1", "ASNS", "ASPH", "ASRGL1", "ATAD3A", "ATAD3B", "ATG3", "ATIC", "ATP13A1", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2C1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6", "ATP6AP1", "ATP6AP2", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1D", "ATP6V1E1", "ATP6V1G1", "ATP6V1H", "ATP7B", "ATPAF1", "ATPIF1", "ATXN2L", "AURKA", "B4GAT1", "BAG3", "BAG5", "BAIAP2", "BANF1", "BCAP31", "BCAS3", "BCCIP", "BCLAF1", "BICD2", "BIRC6", "BLMH", "BLVRA", "BMS1", "BOLA2*", "BOP1", "BPNT1", "BPTF", "BRAT1", "BRIX1", "BSG", "BTAF1", "BTF3", "BUB1B", "BUD23", "BUD31", "BYSL", "C12orf73", "C17orf75", "C19orf70", "C1QBP", "C1orf122", "C1orf123", "C1orf35", "C5orf15", "C5orf51", "C8orf33", "CAB39", "CACUL1", "CAD", "CALD1", "CALR", "CALU", "CAND1", "CAND2", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPNS1", "CAPRIN1", "CAPZA1", "CAPZA2", "CAPZB", "CARM1", "CARS", "CAST", "CBL", "CBR1", "CBX2", "CBX3", "CCAR1", "CCAR2", "CCDC124", "CCDC138", "CCDC22", "CCDC47", "CCDC6", "CCDC86", "CCNB1", "CCNB2", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2AP", "CDC123", "CDC20", "CDC25C", "CDC37", "CDC40", "CDC42", "CDC73", "CDCA8", "CDK5RAP3", "CDK6", "CDV3", "CEBPZ", "CENPF", "CENPP", "CEP55", "CEPT1", "CERS2", "CETN2", "CFAP20", "CFL1", "CFL2", "CHAC2", "CHAF1A", "CHAF1B", "CHAMP1", "CHCHD3", "CHERP", "CHM", "CHMP2A", "CHMP2B", "CHMP7", "CHORDC1", "CHST14", "CIAPIN1", "CIP2A", "CISD2", "CIZ1", "CKAP2", "CKAP4", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLCC1", "CLCN3", "CLCN7", "CLGN", "CLIC1", "CLIC4", "CLINT1", "CLN5", "CLNS1A", "CLPB", "CLPP", "CLPTM1", "CLPTM1L", "CLPX", "CLTC", "CLUH", "CMAS", "CMPK1", "CMTR1", "CNDP2", "CNN2", "CNN3", "CNNM4", "CNOT1", "CNOT2", "CNOT3", "CNOT4", "CNOT7", "CNOT9", "CNP", "CNPY2", "COIL", "COLGALT1", "COMMD2", "COMT", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS7A", "COPS7B", "COPS8", "COPZ1", "COQ3", "COQ8A", "COQ9", "CORO1A", "CORO1C", "CORO7", "COTL1", "COX2", "COX4I1", "COX5A", "COX6C", "COX7A2", "CPD", "CPNE1", "CPNE3", "CPOX", "CPSF6", "CPSF7", "CPT2", "CPVL", "CRNKL1", "CRTAP", "CS", "CSGALNACT2", "CSNK2A1", "CSNK2A2", "CSNK2B", "CSTB", "CSTF1", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTH", "CTNNA1", "CTNNAL1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTPS2", "CTSA", "CTTN", "CTU2", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CWF19L1", "CXorf56", "CXorf57", "CYB5R1", "CYB5R3", "CYC1", "CYFIP1", "CYP20A1", "CYP51A1", "DAP3", "DARS", "DARS2", "DBN1", "DBNL", "DCAF1", "DCAF7", "DCAKD", "DCD", "DCPS", "DCTN2", "DCTN3", "DCTN4", "DCTPP1", "DCUN1D4", "DCXR", "DDB1", "DDOST", "DDRGK1", "DDT", "DDX54", "DEK", "DENR", "DERL1", "DFFA", "DHCR24", "DHCR7", "DHFR", "DHRS1", "DHRS7", "DHX29", "DIABLO", "DIAPH1", "DIAPH2", "DIAPH3", "DIDO1", "DIEXF", "DIMT1", "DKC1", "DLAT", "DLD", "DLST", "DNA2", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJC10", "DNAJC2", "DNAJC8", "DNASE2", "DNM1L", "DNM2", "DNMT1", "DNPH1", "DNTTIP2", "DOCK7", "DOHH", "DPH2", "DPH5", "DPM1", "DPP3", "DPY30", "DPYSL2", "DPYSL5", "DR1", "DRG1", "DRG2", "DSC1", "DSC3", "DSG2", "DSP", "DST", "DSTN", "DTYMK", "DUSP12", "DUSP3", "DUSP9", "DUT", "DYNC1LI1", "DYNC1LI2", "DYNC2H1", "DYNLL1", "EBNA1BP2", "ECD", "ECE1", "ECH1", "ECHS1", "ECI1", "ECI2", "ECSIT", "EDC4", "EEF1A2", "EEF1E1", "EEF1G", "EFHD1", "EHD1", "EHD4", "EIF2A", "EIF2B1", "EIF2B2", "EIF2B4", "EIF2D", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4B", "EIF4E", "EIF4G1", "EIF4G2", "EIF4G3", "EIF5", "EIF5A", "EIF5B", "ELAVL1", "ELMO2", "ELMOD2", "ELOA", "ELOB", "ELOC", "ELP1", "ELP2", "ELP3", "ELP4", "EMC1", "EMC2", "EMC7", "EMD", "EMG1", "ENDOD1", "ENO1", "ENO2", "ENSA", "EPB41", "EPB41L2", "EPB41L5", "EPDR1", "EPHA7", "EPHX1", "EPHX2", "EPPK1", "EPRS", "ERAL1", "ERAP1", "ERCC2", "ERG28", "ERGIC3", "ERH", "ERLIN1", "ERLIN2", "ERMP1", "ERO1A", "ERP29", "ESD", "ESF1", "ETF1", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXO1", "EXOC2", "EXOC3", "EXOC5", "EXOC7", "EXOSC10", "EXOSC2", "EXOSC3", "EZR", "FAH", "FAM114A2", "FAM129B", "FAM162A", "FAM192A", "FAM213A", "FAM49B", "FAM8A1", "FAM98B", "FANCI", "FAR1", "FARSA", "FARSB", "FAU", "FBL", "FDFT1", "FDPS", "FECH", "FEN1", "FH", "FHOD1", "FIS1", "FKBP3", "FKBP4", "FKBP5", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FMR1", "FN3KRP", "FNTB", "FRG1", "FSCN1", "FTO", "FTSJ3", "FUCA1", "FUCA2", "FUNDC2", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GADD45GIP1", "GALK1", "GALM", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GBA", "GCAT", "GCFC2", "GCLC", "GCLM", "GCN1", "GDI1", "GDI2", "GEMIN4", "GET4", "GFM1", "GFPT1", "GGCT", "GGCX", "GGH", "GGNBP2", "GHDC", "GHITM", "GINS3", "GINS4", "GLA", "GLB1", "GLDC", "GLG1", "GLMN", "GLO1", "GLOD4", "GLRX3", "GLRX5", "GLS", "GLUD1", "GM2A", "GMFB", "GNA13", "GNAI1", "GNAI2", "GNAI3", "GNL1", "GNL2", "GNPAT", "GNPDA1", "GNS", "GOLGA3", "GOLGB1", "GOLIM4", "GOLT1B", "GOPC", "GORASP2", "GOT1", "GOT2", "GPAM", "GPATCH11", "GPD2", "GPI", "GPKOW", "GPR107", "GPR108", "GPS1", "GRIPAP1", "GRPEL1", "GRSF1", "GSK3B", "GSR", "GSS", "GSTK1", "GSTM3", "GSTO1", "GSTZ1", "GTF2I", "GTF3C1", "GTF3C3", "GTF3C4", "GTPBP1", "GTPBP10", "GTPBP3", "GTPBP4", "GUF1", "GUSB", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACD3", "HACL1", "HADH", "HADHA", "HADHB", "HAT1", "HAUS3", "HAUS5", "HCCS", "HCFC1", "HDAC2", "HDHD2", "HDHD5", "HEATR1", "HEBP1", "HEBP2", "HECTD1", "HECTD3", "HEXA", "HEXB", "HIBADH", "HIBCH", "HIF1AN", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLCS", "HM13", "HMBS", "HMCES", "HMGA1", "HMGB1", "HMGB3", "HMGCS1", "HMGN2", "HMOX1", "HMOX2", "HNRNPA1", "HNRNPA2B1", "HNRNPC", "HNRNPK", "HNRNPL", "HNRNPLL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HP1BP3", "HPF1", "HPRT1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSDL1", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA13", "HSPA14", "HSPA1B", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPB1", "HSPD1", "HSPE1", "HSPH1", "HYOU1", "IARS", "IARS2", "ICMT", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDI1", "IFT27", "IGBP1", "IGF2BP2", "IK", "IKBIP", "ILF3", "ILKAP", "ILVBL", "IMMT", "IMP4", "IMPACT", "IMPDH1", "IMPDH2", "INA", "INCENP", "INTS14", "INTS7", "INTS9", "IPO4", "IPO5", "IRGQ", "IRS4", "ISCU", "IST1", "ISYNA1", "ITGB1", "ITM2C", "ITPA", "IVD", "JPT2", "JUP", "KARS", "KDELR1", "KDM1A", "KDM3B", "KDSR", "KHDRBS1", "KIAA0319L", "KIAA0368", "KIAA0391", "KIAA1147", "KIAA2013", "KIF15", "KIF18B", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF5B", "KIFBP", "KLC1", "KMT2A", "KPNA1", "KPNA2", "KPNA3", "KPNB1", "KRI1", "KRR1", "KTN1", "LAMP1", "LAMTOR1", "LANCL2", "LAP3", "LARP1", "LARP4", "LARP4B", "LARS", "LARS2", "LAS1L", "LBR", "LDAH", "LDHA", "LDHB", "LEMD2", "LEMD3", "LETM1", "LGALS3", "LGMN", "LIG1", "LIG3", "LIMA1", "LIPA", "LLGL1", "LMAN1", "LNPEP", "LONP1", "LPCAT3", "LRPPRC", "LRRC47", "LSM12", "LSM2", "LSM6", "LSM7", "LSS", "LTA4H", "LTN1", "LTV1", "LUC7L2", "LUC7L3", "LYAR", "M6PR", "MACF1", "MAD2L1", "MAGED2", "MANF", "MAP1B", "MAP1S", "MAP4", "MAPK1", "MAPRE1", "MAPRE2", "MARCKS", "MARS", "MAT2A", "MAT2B", "MAVS", "MBD3", "MBOAT7", "MCCC2", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCMBP", "MCU", "MDH1", "MDH2", "MDN1", "ME1", "MECP2", "MED21", "MED23", "MED24", "MED25", "MED4", "MFN2", "MFSD10", "MFSD3", "MFSD5", "MGEA5", "MGST2", "MGST3", "MICU1", "MID1", "MIF", "MINDY3", "MINPP1", "MIPEP", "MKRN2", "MLEC", "MMGT1", "MMS19", "MOGS", "MORF4L1", "MORF4L2", "MOV10", "MPC2", "MPHOSPH10", "MPHOSPH6", "MPI", "MPST", "MPV17L2", "MRE11", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL14", "MRPL15", "MRPL19", "MRPL21", "MRPL28", "MRPL3", "MRPL37", "MRPL38", "MRPL40", "MRPL44", "MRPL46", "MRPL47", "MRPL48", "MRPL49", "MRPL50", "MRPL53", "MRPL9", "MRPS11", "MRPS2", "MRPS22", "MRPS23", "MRPS25", "MRPS27", "MRPS28", "MRPS30", "MRPS31", "MRPS33", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRPS9", "MRTO4", "MSH2", "MSH3", "MSH6", "MSN", "MTA1", "MTA2", "MTAP", "MTBP", "MTDH", "MTHFD1", "MTHFD1L", "MTHFD2", "MTMR2", "MTMR6", "MTOR", "MTR", "MTX1", "MTX2", "MVK", "MYBBP1A", "MYCBP", "MYDGF", "MYG1", "NAA15", "NAA25", "NAA40", "NAE1", "NAF1", "NAGLU", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NAPG", "NARS", "NAT10", "NAXE", "NBN", "NCAPD2", "NCAPG", "NCAPH", "NCBP1", "NCDN", "NCKAP1", "NCKIPSD", "NCLN", "NCSTN", "NDC1", "NDRG3", "NDUFA4", "NDUFAF7", "NDUFB10", "NDUFB4", "NDUFB5", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS7", "NDUFV1", "NDUFV2", "NEFL", "NEFM", "NELFB", "NELFCD", "NELFE", "NES", "NHP2", "NIPBL", "NLN", "NMD3", "NME1", "NME6", "NME7", "NMT1", "NNT", "NOB1", "NOC2L", "NOC3L", "NOC4L", "NOL10", "NOL11", "NOL6", "NOL7", "NOL9", "NOP14", "NOP2", "NOP53", "NOP56", "NOP58", "NOSIP", "NPC1", "NPC2", "NPEPPS", "NPLOC4", "NPM1", "NRP1", "NSA2", "NSF", "NSUN2", "NSUN5", "NT5C2", "NT5C3B", "NT5DC1", "NT5DC2", "NTHL1", "NTMT1", "NTPCR", "NUB1", "NUBP2", "NUCB1", "NUCB2", "NUCKS1", "NUDC", "NUDCD2", "NUDT1", "NUDT21", "NUFIP2", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP160", "NUP188", "NUP205", "NUP210", "NUP214", "NUP37", "NUP50", "NUP54", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NXF1", "OAT", "OCIAD1", "OCLN", "OGDH", "OGT", "OLA1", "OPA1", "OPA3", "OSBP", "OSBPL8", "OSBPL9", "OSGEP", "OTUB1", "OTULIN", "OXA1L", "OXSR1", "P3H1", "P3H4", "P4HA1", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PAF1", "PAFAH1B1", "PAK2", "PANK4", "PAPOLA", "PAPSS1", "PARK7", "PARN", "PATL1", "PBDC1", "PBRM1", "PC", "PCBD1", "PCK2", "PCLAF", "PCM1", "PCMT1", "PCNA", "PCNP", "PCYOX1", "PDAP1", "PDCD11", "PDCD4", "PDCD5", "PDCD6IP", "PDE6D", "PDHA1", "PDHB", "PDIA3", "PDIA4", "PDIA6", "PDK1", "PDK3", "PDLIM1", "PDRG1", "PDS5A", "PDS5B", "PDXDC1", "PDXK", "PEBP1", "PECR", "PELO", "PES1", "PEX14", "PEX19", "PFAS", "PFDN2", "PFDN4", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGGT1B", "PGK1", "PGLS", "PGM1", "PGM2", "PGM3", "PGP", "PHB", "PHB2", "PHF5A", "PHGDH", "PHIP", "PHKA1", "PICALM", "PIGT", "PIK3C2A", "PIK3R4", "PIN4", "PIP4K2C", "PIR", "PISD", "PITHD1", "PITPNB", "PKM", "PKMYT1", "PLA2G15", "PLBD2", "PLCG1", "PLEC", "PLIN3", "PLRG1", "PLS3", "PM20D2", "PMPCA", "PMPCB", "PNN", "PNO1", "PNP", "PNPT1", "PODXL", "POLA1", "POLA2", "POLD1", "POLD2", "POLD3", "POLE", "POLR1A", "POLR1B", "POLR1E", "POLR2A", "POLR2B", "POLR2G", "POLR3A", "POLR3C", "POLRMT", "PON2", "POP1", "POR", "PPA1", "PPA2", "PPAN", "PPAT", "PPFIA1", "PPHLN1", "PPIH", "PPIL4", "PPM1G", "PPME1", "PPP1CA", "PPP2R1A", "PPP2R2A", "PPP2R5D", "PPP4R1", "PPP5C", "PPT1", "PPT2", "PRAF2", "PRCC", "PRCP", "PRDX2", "PRDX5", "PRDX6", "PREB", "PREP", "PREPL", "PRIM1", "PRIM2", "PRKAG1", "PRKAR1A", "PRKAR2A", "PRKCD", "PRKCSH", "PRKRA", "PRMT1", "PRMT3", "PRMT5", "PRMT9", "PRPF19", "PRPF3", "PRPF31", "PRPF38B", "PRPF40A", "PRPF6", "PRPF8", "PRPS1", "PRPSAP1", "PRPSAP2", "PRRC1", "PRRC2A", "PRRC2C", "PSAP", "PSAT1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD6", "PSMD7", "PSMD8", "PSME1", "PSME2", "PSME3", "PSME4", "PSMF1", "PSMG1", "PSMG2", "PTBP1", "PTBP2", "PTCD3", "PTDSS1", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTPA", "PTPN1", "PTPN11", "PTRH2", "PTRHD1", "PUF60", "PUM3", "PURA", "PUS1", "PUS7", "PWP1", "PWP2", "PXMP2", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QDPR", "QKI", "QSOX2", "RAB10", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB21", "RAB23", "RAB24", "RAB2A", "RAB35", "RAB3GAP2", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RAB8A", "RABGAP1", "RABGGTA", "RABL6", "RAC1", "RACK1", 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b/interpro_homologous_superfamily/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:61b9e0c6b92ec12a97136f8568f658f0246ed838889f47b40b080180f47b2b87 +size 88450 diff --git a/interpro_homologous_superfamily/df_merge.tsv b/interpro_homologous_superfamily/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..1636a93574564f202b1110bd7bcc9a1db878d079 --- /dev/null +++ b/interpro_homologous_superfamily/df_merge.tsv @@ -0,0 +1,10 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Glycoside hydrolase superfamily [IPR017853] 11 17 3.357335602182315 0.0007869752746538 7.094660194174757 15.565533980582524 0.5992585613623983 0.1928722204186086 2.565315823223627 1.245604487832095 1.9386029676344616 0.2695693578719223 5.673974002666338e-11 1.2676801164761754e-07 3.456655046744048e-09 2.2393788387052811e-13 1.8527837357829765e-12 +Immunoglobulin-like fold [IPR013783] 8 24 2.841660393771356 0.004487927033941 9.024271844660197 30.70631067961165 -0.0882371106398617 0.5574652875269992 4.075666983819175 5.992200349595445 1.1066442573771362 0.3307702752839019 0.4131868995399937 0.2944932254508215 0.1707049877158561 0.0965392960738416 0.5321602367084353 +Glycosyl hydrolase, all-beta [IPR013780] 5 8 2.5118428876410626 0.012010254582472 3.628640776699029 7.919902912621359 0.108448733903935 0.2677010542317815 1.6191976609214136 0.9906808437954988 1.5895506376095985 0.2857304479214345 2.7528489700449297e-05 0.0017062060788896 0.0002296483500821 8.796898694645245e-06 1.6091572544199994e-05 +Mitochondrial carrier domain superfamily [IPR023395] 15 20 2.276710837190061 0.0228034989421126 9.148058252427184 20.71359223300971 2.0411027534642088 0.1411881998864352 5.368907349966936 1.8276489510009888 1.309103123363054 0.2428184236965967 0.0174465086842438 1.0 0.0513963234576887 0.0020925837152473 9.016090704967298e-06 +Immunoglobulin-like domain superfamily [IPR036179] 6 8 2.160187820201851 0.0307581326578179 4.480582524271845 12.427184466019416 0.4075261998509777 0.4433674298264088 2.6479725987944898 3.173316973839475 1.1756568118942026 0.3233613924696422 0.4998708030025074 1.0 0.303304644259416 0.146718557832825 0.3231025358113557 +Galactose-binding-like domain superfamily [IPR008979] 4 10 2.058404102461323 0.0395513582615201 3.0266990291262137 10.45388349514563 0.2272915730277323 0.4946686484554474 2.0113188873716883 2.8129916124420524 1.0072294248002038 0.3052099564304033 0.1689977859538334 0.0248381956323572 0.08610744549237 0.0345596402774107 0.099423410284734 +Cytochrome b5-like heme/steroid binding domain superfamily [IPR036400] 3 5 1.9992599546240293 0.0455802345866265 2.813106796116505 6.104368932038835 1.6405397264547834 0.1100883340733615 1.2852875686886795 0.8042848477475721 1.100790504333474 0.1612592696854457 0.0125560894119173 0.0561990347849709 0.1094892401774078 0.000142755965642 0.0001560226497295 +Band 7/SPFH domain superfamily [IPR036013] 3 8 1.9887346361279348 0.046730500813708 3.825242718446602 7.354368932038835 0.2848798017769268 0.3662852929750465 1.8717479731706237 0.7075565364256523 1.25010454777189 0.3076860385713043 0.1360875240376773 0.0470522829573702 0.0921025797166938 0.0231366382468947 0.0009048869233579 +Galactose mutarotase-like domain superfamily [IPR011013] 1 5 1.980025294582092 0.0477006864960007 1.6213592233009708 4.237864077669903 -0.1710088816529627 0.4259251030719748 1.156379559873228 0.9330622415325056 1.182861393037172 0.315870474383572 0.1104285806506277 1.0 1.0 0.0148625463558957 0.0540238893245918 diff --git a/interpro_homologous_superfamily/metrics.json b/interpro_homologous_superfamily/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..f7c3b5bc81531a65c60c31508c592932fa50f2bc --- /dev/null +++ b/interpro_homologous_superfamily/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2644, + "annotations_size": 896, + "title": "Average number of proteins per term", + "value": 4.452008928571429 +} \ No newline at end of file diff --git a/interpro_homologous_superfamily/paths.json b/interpro_homologous_superfamily/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..acf60089019c878672ef4363f6be48a5e08dfd75 --- /dev/null +++ b/interpro_homologous_superfamily/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/interpro_homologous_superfamily/fragment/C197/C197_val_log2fc"} \ No newline at end of file diff --git a/interpro_homologous_superfamily/result.tsv b/interpro_homologous_superfamily/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..20e416b94fdb975c61c978a17333f24b1729b740 --- /dev/null +++ b/interpro_homologous_superfamily/result.tsv @@ -0,0 +1,102 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Glycoside hydrolase superfamily [IPR017853] 0.865505159944381 3.357335602182315 0.0007869752746538 0.5060927100744684 0.6229275437608478 17 P10253,P16278,O00462,P08236,P06280,P07686,P54802,P04066,Q01459,Q9BTY2,P06865 11 +Immunoglobulin-like fold [IPR013783] 0.7477043598838675 2.8416603937713556 0.004487927033941 0.982229812728631 0.6229275437608478 24 Q15375,P01889,O00462,P08236,P04439,Q8IZA0,P10321,P55899 8 +Glycosyl hydrolase, all-beta [IPR013780] 0.8839401905421658 2.5118428876410626 0.012010254582472 0.9999801306563963 0.6229275437608478 8 P10253,P06280,P04066,Q9BTY2,O00754 5 +Mitochondrial carrier domain superfamily [IPR023395] 0.6535802721144071 2.276710837190061 0.0228034989421126 0.9999999989437048 0.6229275437608478 20 Q9HC21,P12235,Q9H2D1,P12236,P05141,Q02978,Q86VD7,Q9UBX3,Q00325,Q6NUK1,O43772,Q9Y619,Q96H78,Q9NZJ7,Q70HW3 15 +MHC class I-like antigen recognition-like superfamily [IPR037055] 0.9344696969696976 2.211935000685298 0.0269711564275496 0.9999999999770576 0.6229275437608478 4 P55899,P01889,P10321 3 +MHC classes I/II-like antigen recognition protein [IPR011162] 0.9344696969696976 2.211935000685298 0.0269711564275496 0.9999999999770576 0.6229275437608478 4 P55899,P01889,P10321 3 +Immunoglobulin-like domain superfamily [IPR036179] 0.8037005606618264 2.160187820201851 0.0307581326578179 0.999999999999303 0.6229275437608478 8 P01889,P35613,P04439,P78310,P10321,P55899 6 +Galactose-binding-like domain superfamily [IPR008979] 0.7159174381371617 2.058404102461323 0.0395513582615201 0.9999999999999998 0.6229275437608478 10 O00462,P08236,Q15375,P16278 4 +Cytochrome b5-like heme/steroid binding domain superfamily [IPR036400] 0.8431482253799534 1.9992599546240295 0.0455802345866265 1.0 0.6229275437608478 5 O15173,Q9UMX5,O43169 3 +Band 7/SPFH domain superfamily [IPR036013] 0.7657695270150455 1.9887346361279348 0.046730500813708 1.0 0.6229275437608478 8 O75955,P27105,Q14254 3 +Beta-hexosaminidase-like, domain 2 [IPR029018] 0.9575918212798196 1.9809518079496389 0.0475966782926233 1.0 0.6229275437608478 3 P54802,P06865 2 +Galactose mutarotase-like domain superfamily [IPR011013] 0.8384815909201382 1.980025294582092 0.0477006864960007 1.0 0.6229275437608478 5 P10253 1 +Porin domain superfamily [IPR023614] 0.8727622101304762 1.9643597444788607 0.0494883877285947 1.0 0.6229275437608478 4 P45880,P21796 2 +Aminopeptidase N-like , N-terminal domain superfamliy [IPR042097] 0.8310580844152108 1.9493511842688092 0.0512534999439111 1.0 0.6229275437608478 5 P09960,Q9UIQ6,P55786 3 +Peptidase M4/M1, CTD superfamily [IPR027268] 0.8310580844152108 1.9493511842688092 0.0512534999439111 1.0 0.6229275437608478 5 P09960,Q9UIQ6,P55786 3 +MFS transporter superfamily [IPR036259] 0.7700742381575143 1.865406211441652 0.0621244873736586 1.0 0.6229275437608478 7 P53985,Q96ES6,Q99808,Q9H2V7,Q16625 5 +P-type ATPase, A domain superfamily [IPR008250] 0.7790829859795405 1.7320628259576831 0.0832623770267044 1.0 0.6404368151644968 5 P05023,P35670,Q9HD20,P16615 4 +P-type ATPase, cytoplasmic domain N [IPR023299] 0.7790829859795405 1.7320628259576831 0.0832623770267044 1.0 0.6404368151644968 5 P05023,P35670,Q9HD20,P16615 4 +P-type ATPase, transmembrane domain superfamily [IPR023298] 0.7790829859795405 1.7320628259576831 0.0832623770267044 1.0 0.6404368151644968 5 P05023,P35670,Q9HD20,P16615 4 +Tetraspanin, EC2 domain superfamily [IPR008952] 0.992429977289932 1.7061448728448674 0.0879811096363463 1.0 0.6404368151644968 2 O43657 1 +Amyloidogenic glycoprotein, copper-binding domain superfamily [IPR036669] 0.9746404239212711 1.6333779899592 0.1023895232075535 1.0 0.641315727918754 2 P05067 1 +E2 domain superfamily [IPR036176] 0.9746404239212711 1.6333779899592 0.1023895232075535 1.0 0.641315727918754 2 P05067 1 +Amyloidogenic glycoprotein, heparin-binding domain superfamily [IPR036454] 0.9746404239212711 1.6333779899592 0.1023895232075535 1.0 0.641315727918754 2 P05067 1 +Pancreatic trypsin inhibitor Kunitz domain superfamily [IPR036880] 0.9746404239212711 1.6333779899592 0.1023895232075535 1.0 0.641315727918754 2 P05067 1 +SKP1/BTB/POZ domain superfamily [IPR011333] 0.7511149705092339 1.613447272377374 0.1066473699329177 1.0 0.641315727918754 5 Q9NXV2,Q96CX2,Q08380 3 +Beta-Galactosidase/glucuronidase domain superfamily [IPR036156] 0.9598788796366382 1.5729363714925944 0.1157335521839577 1.0 0.6719912030454775 2 O00462 1 +Mannose-6-phosphate receptor binding domain superfamily [IPR009011] 0.8479833939340822 1.5434959646980693 0.1227104858284633 1.0 0.6745547322134332 3 P11717 1 +Metallopeptidase, catalytic domain superfamily [IPR024079] 0.7677729634425164 1.5312699523856128 0.1257026885061389 1.0 0.6745547322134332 4 P42892 1 +Alpha/Beta hydrolase fold [IPR029058] 0.5248771782051458 1.4704812010500317 0.1414314734449686 1.0 0.6745547322134332 24 Q9HB40,P10619,P50897,Q8NCC3,P42785,Q9H3G5,Q9H6V9,Q9NUJ1 8 +START-like domain superfamily [IPR023393] 0.7082168526114163 1.4296106174809604 0.1528288065171059 1.0 0.6745547322134332 5 Q9NQZ5 1 +Cytochrome P450 superfamily [IPR036396] 0.8962906888720638 1.3128794744972878 0.1892235642774928 1.0 0.7064346399693068 2 Q16850 1 +Zinc finger, RanBP2-type superfamily [IPR036443] 0.6178031385446371 1.290308109169367 0.1969437024696767 1.0 0.7202512547462464 8 P35637,Q01844 2 +SNARE [IPR010989] 0.7840734348379752 1.2856365654013135 0.1985699292359202 1.0 0.7232465715259532 3 O15400 1 +Ricin B-like lectins [IPR035992] 0.782658084059069 1.279933250392116 0.2005686124058021 1.0 0.7275687316421001 3 Q10472,Q10471 2 +Nucleophile aminohydrolases, N-terminal [IPR029055] 0.4905956211270145 1.262487943706916 0.2067732618525108 1.0 0.7325854309631094 18 P28074,P20618,Q99436,P49720,P49721,P28072,P28070 7 +Ferredoxin-NADP reductase (FNR), nucleotide-binding domain [IPR039261] 0.7771433997231343 1.2577214681048234 0.2084925054638313 1.0 0.7325854309631094 3 P16435 1 +Riboflavin synthase-like beta-barrel [IPR017938] 0.7771433997231343 1.2577214681048234 0.2084925054638313 1.0 0.7325854309631094 3 P16435 1 +Metalloenzyme, LuxS/M16 peptidase-like [IPR011249] 0.6295116526161347 1.2287336160102211 0.2191716981260587 1.0 0.7521482889436123 7 Q5JRX3,Q10713 2 +Membrane associated eicosanoid/glutathione metabolism-like domain superfamily [IPR023352] 0.8667676003028011 1.1930486697118523 0.2328503126656342 1.0 0.7521482889436123 2 Q99735 1 +Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid [IPR008930] 0.7569102612646706 1.1764126401809916 0.2394300230892778 1.0 0.7521482889436123 3 P48449,P49356 2 +K Homology domain, type 1 superfamily [IPR036612] 0.471269755920875 1.1090624096579866 0.2674032597208398 1.0 0.770329531946996 24 Q92945,Q07666,Q96I24,Q96AE4,P51116,P51114,Q06787 7 +Immunoglobulin E-set [IPR014756] 0.5001012404043265 1.107125324717719 0.2682397477315432 1.0 0.770329531946996 13 P61916 1 +Heat shock protein DnaJ, cysteine-rich domain superfamily [IPR036410] 0.7364192222869907 1.0945001923560076 0.2737356630580589 1.0 0.7765080702810004 3 Q96EY1 1 +Chloride channel, core [IPR014743] 0.8398940196820549 1.0850565816207454 0.2778965958513963 1.0 0.7765080702810004 2 P51790 1 +Aldolase-type TIM barrel [IPR013785] 0.50273485215774 1.0496562666658091 0.2938761775807195 1.0 0.7931116117841104 11 P06280 1 +Haem oxygenase-like, multi-helical [IPR016084] 0.8277819833459477 1.0368523369703433 0.2998046798528184 1.0 0.7962664520355561 2 P30519 1 +FAD/NAD(P)-binding domain superfamily [IPR036188] 0.4499469242205853 0.9530505066352098 0.3405644811338317 1.0 0.843525658071256 17 Q14534,Q96CU9,Q9UHG3,Q8NB78 4 +Papain-like cysteine peptidase superfamily [IPR038765] 0.44138295992402 0.918780362064079 0.3582104661489746 1.0 0.867682131668959 21 Q96FW1,P07858 2 +Acyl-CoA N-acyltransferase [IPR016181] 0.5153129545449578 0.7030626021128416 0.4820167370118011 1.0 0.940715854912693 7 Q86UY6,Q9H9T3 2 +Acyl-CoA binding protein superfamily [IPR035984] 0.7339137017411017 0.6800896718731139 0.4964476836801856 1.0 0.940715854912693 2 O75521 1 +RmlC-like jelly roll fold [IPR014710] 0.4714234580921154 0.6719186079113605 0.5016355135163515 1.0 0.940715854912693 9 P10644,Q9NWT6,Q9BV57 3 +Neurolysin/Thimet oligopeptidase, domain 2 [IPR024077] 0.6145431023771605 0.6300523484630068 0.5286603349790446 1.0 0.940715854912693 3 Q9BYT8 1 +H/ACA RNP complex subunit Gar1/Naf1, Cbf5-binding domain [IPR038664] 0.7168811506434483 0.6200568466726483 0.5352203615717994 1.0 0.9414059605838592 2 Q96HR8 1 +PapD-like superfamily [IPR008962] 0.6009087466868532 0.5823865879934066 0.5603063134944588 1.0 0.9631862669689834 3 Q8NHP6,Q9P0L0 2 +TGS-like [IPR012676] 0.4987083532321295 0.5584235444967534 0.5765551990525675 1.0 0.9747046383983028 6 Q9NTK5 1 +R3H domain superfamily [IPR036867] 0.5861416130253636 0.5322458035548973 0.5945557632144713 1.0 0.9938842608958328 3 O95453,Q9H6S0 2 +Beta-grasp domain superfamily [IPR012675] 0.4733534026152069 0.5180373681133867 0.6044321975188229 1.0 0.99810668414558 7 Q9NTK5 1 +Nucleotide-diphospho-sugar transferases [IPR029044] 0.3752452264533156 0.4448100178370965 0.6564570541647385 1.0 1.0 16 Q10472,Q10471,Q16739,Q9Y5P6,Q8N6G5 5 +Profilin superfamily [IPR036140] 0.6616199848599492 0.4404156182303438 0.6596361151342682 1.0 1.0 2 P35080 1 +LEM/LEM-like domain superfamily [IPR011015] 0.4504976213742251 0.3683910390597127 0.7125816781821339 1.0 1.0 6 Q86XL3 1 +HAD-like superfamily [IPR036412] 0.3644411061723968 0.3555327394838378 0.7221905223374181 1.0 1.0 15 P05023,P98194,Q9HD20,Q969T7,P16615,P35670,Q3ZCQ8 7 +HAD superfamily [IPR023214] 0.3644411061723968 0.3555327394838378 0.7221905223374181 1.0 1.0 15 P05023,P98194,Q9HD20,Q969T7,P16615,P35670,Q3ZCQ8 7 +Cadherin-like superfamily [IPR015919] 0.5231767518201947 0.3400572383522252 0.7338134236140064 1.0 1.0 3 Q14574 1 +Catenin binding domain superfamily [IPR027397] 0.5231767518201947 0.3400572383522252 0.7338134236140064 1.0 1.0 3 Q14574 1 +SCP2 sterol-binding domain superfamily [IPR036527] 0.5164710336993535 0.3220276907058437 0.7474317168345703 1.0 1.0 3 P51659,Q6YN16 2 +HIV integrase-binding domain superfamily [IPR036218] 0.6082513247539674 0.2950687930911773 0.7679413284341223 1.0 1.0 2 Q7Z4V5 1 +Zinc-binding ribosomal protein [IPR011332] 0.4899659219992448 0.2560947335572575 0.7978776884352803 1.0 1.0 3 P61927,P61513 2 +Sec1-like, domain 3a [IPR043127] 0.4846648996592022 0.2439752178198262 0.8072500133576326 1.0 1.0 3 Q8WVM8,O00186 2 +Sec1-like superfamily [IPR036045] 0.4846648996592022 0.2439752178198262 0.8072500133576326 1.0 1.0 3 Q8WVM8,O00186 2 +Sec1-like, domain 2 [IPR027482] 0.4846648996592022 0.2439752178198262 0.8072500133576326 1.0 1.0 3 Q8WVM8,O00186 2 +Sec1-like, domain 1 [IPR043154] 0.4846648996592022 0.2439752178198262 0.8072500133576326 1.0 1.0 3 Q8WVM8,O00186 2 +XPC-binding domain superfamily [IPR036353] 0.5730507191521507 0.2176340860467473 0.8277142241755022 1.0 1.0 2 P54725 1 +Homeobox-like domain superfamily [IPR009057] 0.3306939466582059 0.2062795616811868 0.8365725426328792 1.0 1.0 17 Q96G23 1 +Ribosomal protein L1-like [IPR023674] 0.4589170768648138 0.1904171906082035 0.8489822279533978 1.0 1.0 3 O76021,Q9BYD6 2 +Ribosomal protein L1, 3-layer alpha/beta-sandwich [IPR016095] 0.4589170768648138 0.1904171906082035 0.8489822279533978 1.0 1.0 3 O76021,Q9BYD6 2 +Translin, C-terminal [IPR016069] 0.5514761544284548 0.1780120860473755 0.8587134840448181 1.0 1.0 2 Q99598 1 +Translin, N-terminal [IPR016068] 0.5514761544284548 0.1780120860473755 0.8587134840448181 1.0 1.0 2 Q99598 1 +Translin superfamily [IPR036081] 0.5514761544284548 0.1780120860473755 0.8587134840448181 1.0 1.0 2 Q99598 1 +Quinoprotein alcohol dehydrogenase-like superfamily [IPR011047] 0.3812050018946575 0.1514489453133129 0.8796215819230158 1.0 1.0 5 Q8N766,Q15269,Q8IWA0,Q9HCU5 4 +PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily [IPR017946] 0.5344436033308049 0.1509776155874679 0.8799933736464294 1.0 1.0 2 Q8N9F7 1 +Clathrin adaptor, beta-adaptin, appendage, Ig-like subdomain [IPR013037] 0.5219530658591883 0.1334925248557986 0.8938038756634585 1.0 1.0 2 Q10567 1 +PEBP-like superfamily [IPR036610] 0.518168054504154 0.1285764875962499 0.8976927720327159 1.0 1.0 2 Q96DV4 1 +Proteasome activator PA28, N-terminal domain superfamily [IPR036996] 0.4184021204089265 0.1243687497997235 0.9010233152619408 1.0 1.0 3 P61289,Q9UL46 2 +Proteasome activator PA28, C-terminal domain superfamily [IPR036997] 0.4184021204089265 0.1243687497997235 0.9010233152619408 1.0 1.0 3 P61289,Q9UL46 2 +Proteasome activator superfamily [IPR036252] 0.4184021204089265 0.1243687497997235 0.9010233152619408 1.0 1.0 3 P61289,Q9UL46 2 +GTP-binding protein, orthogonal bundle domain superfamily [IPR023179] 0.5143830431491206 0.1238352271486844 0.9014457392459804 1.0 1.0 2 Q9NVN8 1 +Six-hairpin glycosidase superfamily [IPR008928] 0.4176448315032216 0.1233447967832978 0.901834068935584 1.0 1.0 3 P35573,P46020 2 +Ribosomal protein L37ae/L37e [IPR011331] 0.5087055261165689 0.117046560447683 0.9068231571240724 1.0 1.0 2 P61513 1 +ABC transporter type 1, transmembrane domain superfamily [IPR036640] 0.4117905131299706 0.1156828356573919 0.9079039100715928 1.0 1.0 3 P08183 1 +2Fe-2S ferredoxin-like superfamily [IPR036010] 0.5045420136260311 0.1123108824854929 0.9105769134218508 1.0 1.0 2 P28331 1 +Class II aldolase/adducin N-terminal domain superfamily [IPR036409] 0.4757759273277774 0.0849040700003037 0.9323376560814712 1.0 1.0 2 Q9UEY8 1 +DHS-like NAD/FAD-binding domain superfamily [IPR029035] 0.3534707991172316 0.0838220375234994 0.9331979262686 1.0 1.0 4 Q13423 1 +TFIIS/LEDGF domain superfamily [IPR035441] 0.3501326259946972 0.0801964012485126 0.936081052332465 1.0 1.0 5 Q14241,P23193,O75475,Q7Z4V5 4 +GINS, helical bundle-like domain superfamily [IPR036224] 0.4534443603330697 0.0694146671909446 0.9446595543500832 1.0 1.0 2 Q9BRX5 1 +Ribosomal protein L14 superfamily [IPR036853] 0.4454958364875061 0.0649661451761469 0.9482009555240378 1.0 1.0 2 Q6P1L8 1 +Alpha-ketoglutarate-dependent dioxygenase AlkB-like superfamily [IPR037151] 0.4436033308099807 0.0639822774599529 0.9489843384282808 1.0 1.0 2 Q9C0B1 1 +Coatomer, gamma subunit, appendage domain superfamily [IPR037067] 0.4390613171839398 0.0617340849574712 0.9507745958548852 1.0 1.0 2 Q9Y678 1 +CRAL-TRIO lipid binding domain superfamily [IPR036865] 0.3875851627554804 0.0454100574078385 0.9637804646062528 1.0 1.0 2 Q8NHP6 1 +Transcription elongation factor S-II, central domain superfamily [IPR036575] 0.3444360333080926 0.0402613236083672 0.96788478805125 1.0 1.0 2 P23193 1 +Rhodanese-like domain superfamily [IPR036873] 0.314139834107416 0.0382478026216143 0.9694901077766522 1.0 1.0 4 Q99956 1 +Nucleotide-binding alpha-beta plait domain superfamily [IPR012677] 0.3127138421422734 0.0328548369412473 0.97379034823413 1.0 1.0 107 Q8IXT5,P31942,P52597,Q01844,P22626,P35637,P31943,O95628,Q99729,Q9UHX1,Q92804,O14979,Q14103,Q01085,P51991,Q14011,O43390,P38159,P55795,Q8IY67,O60506,Q9BWF3 22 diff --git a/interpro_homologous_superfamily/selections.json b/interpro_homologous_superfamily/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..1f67155606329181a97ef76bff45e6f9a739ecef --- /dev/null +++ b/interpro_homologous_superfamily/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["14-3-3 domain superfamily [IPR036815]", "2Fe-2S ferredoxin-like superfamily [IPR036010]", "30s ribosomal protein S13, C-terminal [IPR027437]", "4'-phosphopantetheinyl transferase domain superfamily [IPR037143]", "5'-3' exonuclease, C-terminal domain superfamily [IPR036279]", "50S ribosomal protein L10, insertion domain superfamily [IPR043164]", "50S ribosomal protein L30e-like [IPR029064]", "6-phosphogluconate dehydrogenase, domain 2 [IPR013328]", "6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily [IPR008927]", "ABC transporter type 1, transmembrane domain superfamily [IPR036640]", "ACP-like superfamily [IPR036736]", "ADF-H/Gelsolin-like domain superfamily [IPR029006]", "ADP-ribosylation/Crystallin J1 superfamily [IPR036705]", "AF1104-like superfamily [IPR036075]", "AH/BAR domain superfamily [IPR027267]", "AICAR transformylase, duplicated domain superfamily [IPR024051]", "AICAR transformylase, insert domain superfamily [IPR024050]", "AMP-binding enzyme, C-terminal domain superfamily [IPR045851]", "ANL, N-terminal domain [IPR042099]", "ANTH domain superfamily [IPR014712]", "AP-2 complex subunit mu, C-terminal superfamily [IPR036168]", "ARFGAP/RecO-like zinc finger [IPR037278]", "ARID DNA-binding domain superfamily [IPR036431]", "ATP synthase subunit alpha, N-terminal domain-like superfamily [IPR023366]", "ATP synthase, F0 complex, subunit A superfamily [IPR035908]", "ATP synthase, F0 complex, subunit D superfamily, mitochondrial [IPR036228]", "ATP synthase, F1 complex, gamma subunit superfamily [IPR035968]", "ATP synthase, alpha subunit, C-terminal domain superfamily [IPR038376]", "ATP-grasp fold, subdomain 1 [IPR013815]", "ATP:guanido phosphotransferase, N-terminal domain superfamily [IPR036802]", "ATPase, F1/V1 complex, beta/alpha subunit, C-terminal [IPR024034]", "ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain superfamily [IPR036121]", "ATPase, V1 complex, subunit H, C-terminal domain superfamily [IPR038497]", "ATPase, nucleotide binding domain [IPR043129]", "Acetylglutamate kinase-like superfamily [IPR036393]", "Aconitase, domain 2 [IPR015932]", "Aconitase, iron-sulfur domain [IPR036008]", "Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 1/3 [IPR015931]", "Aconitase/3-isopropylmalate dehydratase, swivel [IPR015928]", "Actin-crosslinking [IPR008999]", "Actin-related protein 2/3 complex subunit 3 superfamily [IPR036753]", "Activator of Hsp90 ATPase, Aha1 [IPR036338]", "Acyl transferase domain superfamily [IPR001227]", "Acyl transferase/acyl hydrolase/lysophospholipase [IPR016035]", "Acyl-CoA N-acyltransferase [IPR016181]", "Acyl-CoA binding protein superfamily [IPR035984]", "Acyl-CoA dehydrogenase-like, C-terminal [IPR036250]", "Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain superfamily [IPR009100]", "Acyl-CoA dehydrogenase/oxidase, N-terminal domain superfamily [IPR037069]", "Adaptor protein Cbl, N-terminal domain superfamily [IPR036537]", "Adenosylhomocysteinase-like superfamily [IPR042172]", "Adenylate cyclase-associated CAP, C-terminal superfamily [IPR036223]", "Adenylate cyclase-associated CAP, N-terminal domain superfamily [IPR036222]", "Adenylate kinase, active site lid domain superfamily [IPR036193]", "Adenylosuccinate synthetase, domain 1 [IPR042109]", "Adenylosuccinate synthetase, domain 2 [IPR042110]", "Adenylosuccinate synthetase, domain 3 [IPR042111]", "Alanine-tRNA ligase, class IIc, anti-codon-binding domain superfamily [IPR018162]", "Aldehyde dehydrogenase, C-terminal [IPR016163]", "Aldehyde dehydrogenase, N-terminal [IPR016162]", "Aldehyde/histidinol dehydrogenase [IPR016161]", "Aldolase-type TIM barrel [IPR013785]", "Alkaline-phosphatase-like, core domain superfamily [IPR017850]", "Allosteric substrate binding domain superfamily [IPR029009]", "Alpha-D-phosphohexomutase, C-terminal domain superfamily [IPR036900]", "Alpha-D-phosphohexomutase, alpha/beta/alpha I/II/III [IPR016055]", "Alpha-catenin/vinculin-like superfamily [IPR036723]", "Alpha-glycerophosphate oxidase, C-terminal domain superfamily [IPR038299]", "Alpha-helical ferredoxin [IPR009051]", "Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain superfamily [IPR036784]", "Alpha-ketoglutarate-dependent dioxygenase AlkB-like superfamily [IPR037151]", "Alpha/Beta hydrolase fold [IPR029058]", "Alpha/beta knot methyltransferases [IPR029028]", "Aminoacyl-tRNA synthetase, class Ia, anticodon-binding [IPR009080]", "Aminopeptidase N-like , N-terminal domain superfamliy [IPR042097]", "Amyloidogenic glycoprotein, amyloid-beta peptide superfamily [IPR037071]", "Amyloidogenic glycoprotein, copper-binding domain superfamily [IPR036669]", "Amyloidogenic glycoprotein, heparin-binding domain superfamily [IPR036454]", "Ankyrin repeat-containing domain superfamily [IPR036770]", "Annexin superfamily [IPR037104]", "Anticodon-binding domain superfamily [IPR036621]", "Antifreeze-like/N-acetylneuraminic acid synthase C-terminal domain superfamily [IPR036732]", "ApaG domain superfamily [IPR036767]", "ArfGAP domain superfamily [IPR038508]", "Arginyl tRNA synthetase N-terminal domain superfamily [IPR036695]", "Armadillo-like helical [IPR011989]", "Armadillo-type fold [IPR016024]", "Arp2/3 complex subunit 2/4 [IPR034666]", "Arrestin-like, C-terminal [IPR014752]", "Aspartate decarboxylase-like domain superfamily [IPR009010]", "Aspartate/ornithine carbamoyltransferase superfamily [IPR036901]", "Aspartic peptidase domain superfamily [IPR021109]", "At2g17340, three-helix bundle domain [IPR035073]", "B30.2/SPRY domain superfamily [IPR043136]", "BAG domain superfamily [IPR036533]", "BEACH domain superfamily [IPR036372]", "BRCT domain superfamily [IPR036420]", "BRK domain superfamily [IPR037259]", "BRO1 domain superfamily [IPR038499]", "BSD domain superfamily [IPR035925]", "Bacterial exopeptidase dimerisation domain [IPR036264]", "Band 7/SPFH domain superfamily [IPR036013]", "Barrier-to-autointegration factor, BAF superfamily [IPR036617]", "Bcl-2-like superfamily [IPR036834]", "Beta-Galactosidase/glucuronidase domain superfamily [IPR036156]", "Beta-grasp domain superfamily [IPR012675]", "Beta-hexosaminidase-like, domain 2 [IPR029018]", "Beta-lactamase/transpeptidase-like [IPR012338]", "Beta-thymosin superfamily [IPR038386]", "BolA-like superfamily [IPR036065]", "Bromo adjacent homology (BAH) domain superfamily [IPR043151]", "Bromodomain-like superfamily [IPR036427]", "C-type lectin fold [IPR016187]", "C-type lectin-like/link domain superfamily [IPR016186]", "C2 domain superfamily [IPR035892]", "CAP Gly-rich domain superfamily [IPR036859]", "CCR4-NOT complex subunit 2/3/5, N-terminal domain superfamily [IPR038635]", "CCR4-NOT subunit 1, TTP binding domain superfamily [IPR038535]", "CDC48 domain 2-like superfamily [IPR029067]", "CDP-alcohol phosphatidyltransferase, transmembrane domain [IPR043130]", "CH domain superfamily [IPR036872]", "CRAL-TRIO lipid binding domain superfamily [IPR036865]", "CRAL/TRIO, N-terminal domain superfamily [IPR036273]", "CRIB domain superfamily [IPR036936]", "CSTF1, dimerization domain superfamily [IPR038184]", "Cadherin-like superfamily [IPR015919]", "Calcyclin-binding protein, N-terminal [IPR037201]", "Calpain large subunit, domain III superfamily [IPR036213]", "Calreticulin/calnexin, P domain superfamily [IPR009033]", "Carbamoyl-phosphate synthase small subunit, N-terminal domain superfamily [IPR036480]", "Carbamoyl-phosphate synthetase, large subunit oligomerisation domain superfamily [IPR036897]", "Carbohydrate-binding-like fold [IPR013784]", "Carboxypeptidase-like, regulatory domain superfamily [IPR008969]", "Carnitine o-acyltransferase, N-terminal [IPR042572]", "Casein kinase II subunit beta-like [IPR035991]", "Casein kinase II, regulatory subunit, N-terminal [IPR016149]", "Catenin binding domain superfamily [IPR027397]", "Cathepsin C, exclusion domain superfamily [IPR036496]", "Cation efflux transmembrane domain superfamily [IPR027469]", "Cdc37, Hsp90-binding domain superfamily [IPR038189]", "Cell division control protein 73, C-terminal domain superfamily [IPR038103]", "Chaperone J-domain superfamily [IPR036869]", "Chitinase insertion domain superfamily [IPR029070]", "Chloramphenicol acetyltransferase-like domain superfamily [IPR023213]", "Chloride channel, core [IPR014743]", "Choline/Carnitine o-acyltransferase, domain 2 [IPR042231]", "Chromo-like domain superfamily [IPR016197]", "Citrate synthase superfamily [IPR036969]", "Citrate synthase-like, large alpha subdomain [IPR016142]", "Citrate synthase-like, small alpha subdomain [IPR016143]", "Class I and II aminoacyl-tRNA synthetase, tRNA-binding arm [IPR010978]", "Class I glutamine amidotransferase-like [IPR029062]", "Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL) [IPR045864]", "Class II aldolase/adducin N-terminal domain superfamily [IPR036409]", "Clathrin adaptor, appendage, Ig-like subdomain superfamily [IPR013041]", "Clathrin adaptor, beta-adaptin, appendage, Ig-like subdomain [IPR013037]", "Clathrin heavy chain, N-terminal [IPR016025]", "ClpP/crotonase-like domain superfamily [IPR029045]", "Coatomer, gamma subunit, appendage domain superfamily [IPR037067]", "Coatomer/calthrin adaptor appendage, C-terminal subdomain [IPR009028]", "Cobalamin-binding domain superfamily [IPR036724]", "Concanavalin A-like lectin/glucanase domain superfamily [IPR013320]", "Creatinase/Aminopeptidase P/Spt16, N-terminal [IPR029149]", "Creatinase/aminopeptidase-like [IPR036005]", "Cullin homology domain superfamily [IPR036317]", "Cullin repeat-like-containing domain superfamily [IPR016159]", "Cupredoxin [IPR008972]", "Cyclase-associated protein CAP/septum formation inhibitor MinC, C-terminal [IPR016098]", "Cyclic nucleotide-binding-like [IPR018490]", "Cyclic phosphodiesterase [IPR009097]", "Cyclin-like superfamily [IPR036915]", "Cyclophilin-like domain superfamily [IPR029000]", "Cytidine deaminase-like [IPR016193]", "Cytochrome C oxidase subunit II, transmembrane domain superfamily [IPR036257]", "Cytochrome P450 superfamily [IPR036396]", "Cytochrome b-c1 complex subunit 8 superfamily [IPR036642]", "Cytochrome b-c1 complex subunit 9 superfamily [IPR036656]", "Cytochrome b5-like heme/steroid binding domain superfamily [IPR036400]", "Cytochrome c oxidase subunit IV superfamily [IPR036639]", "Cytochrome c oxidase, subunit VIIa superfamily [IPR036539]", "Cytochrome c oxidase, subunit Va/VI superfamily [IPR036545]", "Cytochrome c-like domain superfamily [IPR036909]", "Cytochrome c1, transmembrane anchor, C-terminal [IPR021157]", "Cytochrome cd1-nitrite reductase-like, haem d1 domain superfamily [IPR011048]", "DCN1-like, PONY binding domain [IPR042460]", "DHBP synthase RibB-like alpha/beta domain superfamily [IPR017945]", "DHS-like NAD/FAD-binding domain superfamily [IPR029035]", "DNA breaking-rejoining enzyme, catalytic core [IPR011010]", "DNA fragmentation factor 45kDa, C-terminal [IPR027296]", "DNA glycosylase [IPR011257]", "DNA ligase, ATP-dependent, N-terminal domain superfamily [IPR036599]", "DNA mismatch repair protein MutS, N-terminal [IPR016151]", "DNA mismatch repair protein MutS, core domain superfamily [IPR036187]", "DNA polymerase III, clamp loader complex, gamma/delta/delta subunit, C-terminal [IPR008921]", "DNA polymerase alpha, subunit B, N-terminal domain superfamily [IPR043034]", "DNA polymerase alpha, zinc finger domain superfamily [IPR038256]", "DNA polymerase delta subunit 3 superfamily [IPR041913]", "DNA polymerase family B, thumb domain [IPR042087]", "DNA polymerase, palm domain superfamily [IPR023211]", "DNA repair protein XRCC4-like, C-terminal [IPR014751]", "DNA topoisomerase I, DNA binding, N-terminal domain 1 [IPR013034]", "DNA topoisomerase I, DNA binding, N-terminal domain 2 [IPR013030]", "DNA topoisomerase I, DNA binding, eukaryotic-type, N-terminal domain superfamily [IPR036202]", "DNA topoisomerase I, catalytic core, alpha-helical subdomain, eukaryotic-type [IPR014711]", "DNA topoisomerase I, catalytic core, alpha/beta subdomain [IPR014727]", "DNA topoisomerase, type IIA, alpha-helical domain superfamily [IPR013757]", "DNA topoisomerase, type IIA, domain A, alpha-beta [IPR013758]", "DNA topoisomerase, type IIA, subunit B, C-terminal [IPR013759]", "DNA topoisomerase, type IIA-like domain superfamily [IPR013760]", "DNA-binding domain superfamily [IPR016177]", "DNA-directed RNA polymerase, N-terminal domain superfamily [IPR037159]", "DNA-directed RNA polymerase, insert domain superfamily [IPR036643]", "DNA-directed RNA polymerase, subunit 2, hybrid-binding domain superfamily [IPR037033]", "DNA/RNA non-specific endonuclease superfamily [IPR044929]", "DNA/RNA polymerase superfamily [IPR043502]", "DUSP-like superfamily [IPR035927]", "Dbl homology (DH) domain superfamily [IPR035899]", "Death-like domain superfamily [IPR011029]", "Dedicator of cytokinesis, C-terminal, lobe A [IPR043161]", "Dedicator of cytokinesis, C-terminal, lobe C [IPR043162]", "Diaphanous, GTPase-binding domain superfamily [IPR044933]", "Dihydrofolate reductase-like domain superfamily [IPR024072]", "Dihydropteroate synthase-like [IPR011005]", "Diphthamide synthesis DPH1/DPH2, domain 1 [IPR042263]", "Diphthamide synthesis DPH1/DPH2, domain 3 [IPR042265]", "Dynein heavy chain AAA lid domain superfamily [IPR042219]", "Dynein heavy chain, AAA1 domain, small subdomain [IPR043157]", "Dynein heavy chain, C-terminal domain, barrel region [IPR043160]", "Dynein heavy chain, domain 2, N-terminal [IPR042222]", "Dynein heavy chain, linker, subdomain 3 [IPR042228]", "Dynein light chain superfamily [IPR037177]", "E2 domain superfamily [IPR036176]", "E3 ubiquitin-protein ligase ELL-like [IPR042065]", "E3-binding domain superfamily [IPR036625]", "EB1, C-terminal domain superfamily [IPR036133]", "EF-G domain III/V-like [IPR035647]", "EF-hand domain pair [IPR011992]", "ENTH/VHS [IPR008942]", "ERO1-like superfamily [IPR037192]", "ERV/ALR sulfhydryl oxidase domain superfamily [IPR036774]", "ESCRT assembly domain [IPR037202]", "EXOC6/PINT-1/Sec15/Tip20, C-terminal, domain 2 [IPR042044]", "Elongation factor EF1B gamma, C-terminal domain superfamily [IPR036433]", "Elongation factor Ts, dimerisation domain superfamily [IPR036402]", "Endonuclease/exonuclease/phosphatase superfamily [IPR036691]", "Endoplasmic reticulum resident protein 29, C-terminal domain superfamily [IPR036356]", "Enhancer of mRNA-decapping protein 4, conserved C-terminal domain [IPR044938]", "Enhancer of rudimentary superfamily [IPR035912]", "Enolase-like, C-terminal domain superfamily [IPR036849]", "Enolase-like, N-terminal [IPR029017]", "Enoyl-CoA hydratase, C-terminal [IPR014748]", "Eukaryotic translation initiation factor 3-like domain superfamily [IPR023194]", "Exocyst complex component EXOC3/Sec6, C-terminal domain [IPR042532]", "Exoribonuclease, PH domain 2 superfamily [IPR036345]", "F-actin capping protein, alpha subunit, domain 1 [IPR042489]", "F-actin-capping protein subunit alpha/beta [IPR037282]", "F-actin-capping protein subunit alpha/beta, domain 2 [IPR042276]", "F-actin-capping protein subunit beta, N-terminal domain [IPR043175]", "F-box-like domain superfamily [IPR036047]", "F1F0 ATP synthase OSCP/delta subunit, N-terminal domain superfamily [IPR026015]", "FAD-binding, type PCMH, subdomain 1 [IPR016167]", "FAD-binding, type PCMH, subdomain 2 [IPR016169]", "FAD-binding, type PCMH-like superfamily [IPR036318]", "FAD-linked oxidase-like, C-terminal [IPR016164]", "FAD/NAD(P)-binding domain superfamily [IPR036188]", "FAD/NAD-linked reductase, dimerisation domain superfamily [IPR016156]", "FERM superfamily, second domain [IPR035963]", "FERM/acyl-CoA-binding protein superfamily [IPR014352]", "FF domain superfamily [IPR036517]", "FKBP12-rapamycin binding domain superfamily [IPR036738]", "FTO, C-terminal domain superfamily [IPR038413]", "Fe-S cluster assembly domain superfamily [IPR034904]", "Ferredoxin-NADP reductase (FNR), nucleotide-binding domain [IPR039261]", "Ferritin-like superfamily [IPR009078]", "Fibronectin type II domain superfamily [IPR036943]", "Fibronectin type III superfamily [IPR036116]", "Flavoprotein-like superfamily [IPR029039]", "Formin, FH2 domain superfamily [IPR042201]", "Formyl transferase, N-terminal domain superfamily [IPR036477]", "Fumarase/histidase, N-terminal [IPR024083]", "Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain superfamily [IPR037099]", "Fumarylacetoacetase, N-terminal domain superfamily [IPR036462]", "Fumarylacetoacetase-like, C-terminal domain superfamily [IPR036663]", "G protein alpha subunit, helical insertion [IPR011025]", "GAD-like domain superfamily [IPR004115]", "GAR domain superfamily [IPR036534]", "GAT domain superfamily [IPR038425]", "GHMP kinase, C-terminal domain superfamily [IPR036554]", "GINS complex, subunit Psf3 superfamily [IPR038437]", "GINS, helical bundle-like domain superfamily [IPR036224]", "GM2-AP, lipid-recognition domain superfamily [IPR036846]", "GMP phosphodiesterase, delta subunit superfamily [IPR037036]", "GOLD domain superfamily [IPR036598]", "GSKIP domain superfamily [IPR023231]", "GTF2I-like repeat superfamily [IPR036647]", "GTP-binding protein TrmE/Aminomethyltransferase GcvT, domain 1 [IPR027266]", "GTP-binding protein, orthogonal bundle domain superfamily [IPR023179]", "GTP1/OBG domain superfamily [IPR036726]", "GYF-like domain superfamily [IPR035445]", "Galactose mutarotase-like domain superfamily [IPR011013]", "Galactose oxidase/kelch, beta-propeller [IPR011043]", "Galactose-binding-like domain superfamily [IPR008979]", "Gamma-glutamyl cyclotransferase-like superfamily [IPR036568]", "Gamma-tubulin complex component, C-terminal domain superfamily [IPR042241]", "Gelsolin-like domain superfamily [IPR036180]", "Glutamine synthetase/guanido kinase, catalytic domain [IPR014746]", "Glutaminyl-tRNA synthetase, class Ib, non-specific RNA-binding domain, N-terminal, subdomain 1 [IPR042558]", "Glutaminyl-tRNA synthetase, class Ib, non-specific RNA-binding domain, N-terminal, subdomain 2 [IPR042559]", "Glutathione S-transferase, C-terminal domain superfamily [IPR036282]", "Glutathione synthase, C-terminal, eukaryotic [IPR014709]", "Glutathione synthase, N-terminal, eukaryotic [IPR014049]", "Glutathione synthase, alpha-helical [IPR014042]", "Glutathione synthase, substrate-binding domain superfamily [IPR037013]", "Glycine cleavage T-protein/YgfZ, C-terminal [IPR029043]", "Glycoside hydrolase 38, N-terminal domain superfamily [IPR027291]", "Glycoside hydrolase families 57/38, central domain superfamily [IPR028995]", "Glycoside hydrolase family 38, central domain superfamily [IPR037094]", "Glycoside hydrolase superfamily [IPR017853]", "Glycoside hydrolase-type carbohydrate-binding [IPR014718]", "Glycoside hydrolase/deacetylase, beta/alpha-barrel [IPR011330]", "Glycosyl hydrolase family 63, N-terminal domain superfamily [IPR038518]", "Glycosyl hydrolase, all-beta [IPR013780]", "Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase [IPR029068]", "GroEL-like apical domain superfamily [IPR027409]", "GroEL-like equatorial domain superfamily [IPR027413]", "GroES chaperonin superfamily [IPR037124]", "GroES-like superfamily [IPR011032]", "Growth arrest and DNA damage-inducible proteins-interacting protein 1 domain superfamily [IPR043035]", "Growth factor receptor cysteine-rich domain superfamily [IPR009030]", "GrpE nucleotide exchange factor, coiled-coil [IPR013805]", "GrpE nucleotide exchange factor, head [IPR009012]", "Guanylate-binding protein, C-terminal domain superfamily [IPR036543]", "H/ACA RNP complex subunit Gar1/Naf1, Cbf5-binding domain [IPR038664]", "HAD superfamily [IPR023214]", "HAD-like superfamily [IPR036412]", "HBS1-like protein, N-terminal domain superfamily [IPR037189]", "HECT, E3 ligase catalytic domain [IPR035983]", "HIT-like superfamily [IPR036265]", "HIV integrase-binding domain superfamily [IPR036218]", "HORMA domain superfamily [IPR036570]", "HR1 repeat superfamily [IPR036274]", "HRDC domain superfamily [IPR044876]", "HRDC-like superfamily [IPR010997]", "HSP20-like chaperone [IPR008978]", "HSP40/DnaJ peptide-binding [IPR008971]", "HSP90, C-terminal domain [IPR037196]", "Haem oxygenase-like, multi-helical [IPR016084]", "Heat shock protein 70kD, C-terminal domain superfamily [IPR029048]", "Heat shock protein 70kD, peptide-binding domain superfamily [IPR029047]", "Heat shock protein DnaJ, cysteine-rich domain superfamily [IPR036410]", "Heavy metal-associated domain superfamily [IPR036163]", "Helix-hairpin-helix, base-excision DNA repair, C-terminal [IPR023170]", "Hemimethylated DNA-binding domain superfamily [IPR036623]", "High mobility group box domain superfamily [IPR036910]", "His-Me finger superfamily [IPR044925]", "Histidine kinase/HSP90-like ATPase superfamily [IPR036890]", "Histidine phosphatase superfamily [IPR029033]", "Histone acetyl transferase 1, N-terminal domain superfamily [IPR037113]", "Histone acetyltransferase HAT1, C-terminal [IPR013523]", "Histone deacetylase domain superfamily [IPR037138]", "Histone-fold [IPR009072]", "Homeobox-like domain superfamily [IPR009057]", "Homocysteine-binding domain superfamily [IPR036589]", "HotDog domain superfamily [IPR029069]", "Hypoxia-inducible factor 1-alpha inhibitor, domain II [IPR027452]", "I/LWEQ domain superfamily [IPR035964]", "ISWI, HAND domain superfamily [IPR036306]", "Immunoglobulin E-set [IPR014756]", "Immunoglobulin-like domain superfamily [IPR036179]", "Immunoglobulin-like fold [IPR013783]", "Impact, N-terminal domain superfamily [IPR036956]", "Importin-alpha, importin-beta-binding domain superfamily [IPR036975]", "Initiation factor 2B-like, C-terminal [IPR042529]", "Inorganic polyphosphate/ATP-NAD kinase, N-terminal [IPR017438]", "Inorganic pyrophosphatase superfamily [IPR036649]", "Inosine triphosphate pyrophosphatase-like [IPR029001]", "Integrase-like, N-terminal [IPR017856]", "Integrin beta tail domain superfamily [IPR036349]", "Integrin domain superfamily [IPR032695]", "Interferon regulatory factor 2-binding protein 1/2, C3HC4-type RING finger superfamily [IPR044882]", "Invasin/intimin cell-adhesion fragments [IPR008964]", "Isochorismatase-like superfamily [IPR036380]", "Isopenicillin N synthase-like superfamily [IPR027443]", "Isoprenoid synthase domain superfamily [IPR008949]", "K Homology domain, type 1 superfamily [IPR036612]", "K homology domain superfamily, prokaryotic type [IPR009019]", "K homology domain-like, alpha/beta [IPR015946]", "Kelch-type beta propeller [IPR015915]", "Kinesin motor domain superfamily [IPR036961]", "Kinesin-like protein Kif23, Arf6-interacting domain superfamily [IPR038105]", "Kringle-like fold [IPR013806]", "Ku, C-terminal domain superfamily [IPR036494]", "Ku70, bridge and pillars domain superfamily [IPR027388]", "L-Aspartase-like [IPR008948]", "L21-like superfamily [IPR036164]", "L27 domain superfamily [IPR036892]", "L28p-like [IPR034704]", "LAP1C-like, C-terminal domain superfamily [IPR038599]", "LDL receptor-like superfamily [IPR036055]", "LEM/LEM-like domain superfamily [IPR011015]", "LIS1, N-terminal [IPR037190]", "LSM domain superfamily [IPR010920]", "Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal [IPR015955]", "Lambda repressor-like, DNA-binding domain superfamily [IPR010982]", "Lamin tail domain superfamily [IPR036415]", "LepA, C-terminal domain superfamily [IPR038363]", "Leucine-rich repeat domain superfamily [IPR032675]", "LexA/Signal peptidase-like superfamily [IPR036286]", "Longin-like domain superfamily [IPR011012]", "MAGE homology domain, winged helix WH1 motif [IPR041898]", "MAGE homology domain, winged helix WH2 motif [IPR041899]", "MAN1, winged-helix domain [IPR041885]", "MFS transporter superfamily [IPR036259]", "MHC class I-like antigen recognition-like superfamily [IPR037055]", "MHC classes I/II-like antigen recognition protein [IPR011162]", "MIT domain superfamily [IPR036181]", "MRG, C-terminal domain superfamily [IPR038217]", "MRP-L47 superfamily, mitochondrial [IPR038340]", "Macro domain-like [IPR043472]", "Malic enzyme, N-terminal domain superfamily [IPR037062]", "Malonyl-CoA ACP transacylase, ACP-binding [IPR016036]", "Manganese/iron superoxide dismutase, C-terminal domain superfamily [IPR036314]", "Manganese/iron superoxide dismutase, N-terminal domain superfamily [IPR036324]", "Mannose-6-phosphate receptor binding domain superfamily [IPR009011]", "Mediator complex subunit 25, PTOV domain superfamily [IPR038196]", "Mediator complex, subunit Med7/Med21-like [IPR037212]", "Membrane associated eicosanoid/glutathione metabolism-like domain superfamily [IPR023352]", "Metal-dependent hydrolase [IPR032466]", "Metal-dependent hydrolase, composite domain superfamily [IPR011059]", "Metallo-dependent phosphatase-like [IPR029052]", "Metalloenzyme, LuxS/M16 peptidase-like [IPR011249]", "Metallopeptidase, catalytic domain superfamily [IPR024079]", "Methionine synthase domain [IPR036594]", "Methionyl-tRNA synthetase, Zn-domain [IPR029038]", "Methylglyoxal synthase-like domain superfamily [IPR036914]", "Mib/herc2 domain superfamily [IPR037252]", "MitoNEET, CDGSH iron-sulfur domain [IPR042216]", "Mitochondrial carrier domain superfamily [IPR023395]", "Mitochondrial cytochrome c oxidase subunit VIc/VIIs superfamily [IPR037169]", "Mitochondrial glycoprotein superfamily [IPR036561]", "Mitochondrial outer membrane translocase complex, Tom20 domain superfamily [IPR023392]", "MoaB/Mog-like domain superfamily [IPR036425]", "Moesin tail domain superfamily [IPR008954]", "Mog1/PsbP, alpha/beta/alpha sandwich [IPR016123]", "Mre11, capping domain [IPR038487]", "Mss4-like superfamily [IPR011057]", "Mss4/translationally controlled tumour-associated TCTP [IPR011323]", "Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal domain superfamily [IPR042179]", "MutS, connector domain superfamily [IPR036678]", "Myosin S1 fragment, N-terminal [IPR008989]", "NAC A/B domain superfamily [IPR038187]", "NAD kinase/diacylglycerol kinase-like domain superfamily [IPR016064]", "NAD(P)-binding domain superfamily [IPR036291]", "NADH-quinone oxidoreductase subunit E, N-terminal [IPR041921]", "NADH-ubiquinone oxidoreductase 51kDa subunit, FMN-binding domain superfamily [IPR037225]", "NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain superfamily [IPR037207]", "NADH:ubiquinone oxidoreductase, 30kDa subunit superfamily [IPR037232]", "NADP-dependent oxidoreductase domain superfamily [IPR036812]", "NADPH-cytochrome p450 reductase, FAD-binding, alpha-helical domain superfamily [IPR023173]", "NAP-like superfamily [IPR037231]", "NET domain superfamily [IPR038336]", "NO signalling/Golgi transport ligand-binding domain superfamily [IPR024096]", "NOB1 zinc finger-like superfamily [IPR036283]", "NSFL1 cofactor p47, SEP domain superfamily [IPR036241]", "NTF2-like domain superfamily [IPR032710]", "NUDIX hydrolase-like domain superfamily [IPR015797]", "NVL2, N-terminal domain superfamily [IPR038100]", "NagB/RpiA transferase-like [IPR037171]", "Neurolysin/Thimet oligopeptidase, N-terminal [IPR024080]", "Neurolysin/Thimet oligopeptidase, domain 2 [IPR024077]", "Nibrin, second BRCT domain superfamily [IPR043014]", "Nicotinate phosphoribosyltransferase-like, C-terminal [IPR036068]", "Nitrous oxide reductase, N-terminal [IPR011045]", "Nop domain superfamily [IPR036070]", "Nop, C-terminal domain [IPR042239]", "Nucleic acid-binding, OB-fold [IPR012340]", "Nucleophile aminohydrolases, N-terminal [IPR029055]", "Nucleoplasmin core domain superfamily [IPR036824]", "Nucleoporin, Nup155-like, C-terminal, subdomain 1 [IPR042533]", "Nucleoporin, Nup155-like, C-terminal, subdomain 2 [IPR042537]", "Nucleoporin, Nup155-like, C-terminal, subdomain 3 [IPR042538]", "Nucleoside diphosphate kinase-like domain superfamily [IPR036850]", "Nucleoside phosphorylase superfamily [IPR035994]", "Nucleotide-binding alpha-beta plait domain superfamily [IPR012677]", "Nucleotide-diphospho-sugar transferases [IPR029044]", "Nucleotidyltransferase superfamily [IPR043519]", "Nucleotidyltransferase, class I-like, C-terminal [IPR011068]", "Nuf2, N-terminal domain superfamily [IPR038275]", "NusG, N-terminal domain superfamily [IPR036735]", "Oxygen-dependent coproporphyrinogen III oxidase superfamily [IPR036406]", "Oxysterol-binding protein superfamily [IPR037239]", "P-loop containing nucleoside triphosphate hydrolase [IPR027417]", "P-type ATPase, A domain superfamily [IPR008250]", "P-type ATPase, cytoplasmic domain N [IPR023299]", "P-type ATPase, transmembrane domain superfamily [IPR023298]", "P-type trefoil domain superfamily [IPR044913]", "PABC (PABP) domain [IPR036053]", "PADR1 domain superfamily [IPR038650]", "PBDC1-like domain superfamily [IPR023139]", "PD-(D/E)XK endonuclease-like domain superfamily [IPR011604]", "PDCD5-like superfamily [IPR036883]", "PDZ superfamily [IPR036034]", "PEBP-like superfamily [IPR036610]", "PFU domain superfamily [IPR038122]", "PH-like domain superfamily [IPR011993]", "PIN-like domain superfamily [IPR029060]", "PITH domain superfamily [IPR037047]", "PKD domain superfamily [IPR035986]", "PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily [IPR017946]", "PNPase/RNase PH domain superfamily [IPR027408]", "POLO box domain superfamily [IPR036947]", "PPM-type phosphatase domain superfamily [IPR036457]", "PRP4-like superfamily [IPR036285]", "PTPA superfamily [IPR037218]", "PUA domain superfamily [IPR036974]", "PUA-like superfamily [IPR015947]", "PWI domain superfamily [IPR036483]", "PX domain superfamily [IPR036871]", "Paired amphipathic helix superfamily [IPR036600]", "Pancreatic trypsin inhibitor Kunitz domain superfamily [IPR036880]", "PapD-like superfamily [IPR008962]", "Papain-like cysteine peptidase superfamily [IPR038765]", "Pectin lyase fold [IPR012334]", "Pectin lyase fold/virulence factor [IPR011050]", "Pelota/DOM34, N-terminal domain [IPR038069]", "Peptidase C12, ubiquitin carboxyl-terminal hydrolase superfamily [IPR036959]", "Peptidase C65, otubain, subdomain 2 [IPR042467]", "Peptidase C65, otubain, subdomain 1 [IPR042468]", "Peptidase M1, LTA-4 hydrolase/aminopeptidase, C-terminal domain superfamily [IPR038502]", "Peptidase M13, domain 2 [IPR042089]", "Peptidase M4/M1, CTD superfamily [IPR027268]", "Peptidase M41-like [IPR037219]", "Peptidase S59, nucleoporin superfamily [IPR036903]", "Peptidase S8/S53 domain superfamily [IPR036852]", "Peptidyl-tRNA hydrolase II domain superfamily [IPR023476]", "Pex19, C-terminal domain superfamily [IPR038322]", "Phenylalanyl-tRNA synthetase-like, B3/B4 [IPR020825]", "Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily [IPR036940]", "Phosphatidylinositol-4-phosphate 5-kinase, N-terminal [IPR027484]", "Phosphoenolpyruvate carboxykinase, C-terminal [IPR013035]", "Phosphoenolpyruvate carboxykinase, N-terminal [IPR008210]", "Phosphofructokinase superfamily [IPR035966]", "Phosphoglucose isomerase, C-terminal [IPR023096]", "Phosphoglycerate kinase superfamily [IPR036043]", "Phosphoglycerate kinase, N-terminal [IPR015824]", "Phosphoglycolate phosphatase-like, domain 2 [IPR023198]", "Phosphoinositide 3-kinase, accessory (PIK) domain superfamily [IPR042236]", "Phospholipase B-like, domain 1 [IPR043040]", "Phospholipase B-like, domain 2 [IPR043041]", "Phospholipase B-like, domain 3 [IPR043042]", "Phosphoribosylformylglycinamidine synthase subunit PurS-like superfamily [IPR036604]", "Phosphoribosylglycinamide synthetase, C-domain superfamily [IPR037123]", "Phosphoribosyltransferase-like [IPR029057]", "Phosphotransferase/anion transporter [IPR016152]", "Phosphotyrosine protein phosphatase I superfamily [IPR036196]", "Phosphotyrosyl phosphatase activator, C-terminal lid domain [IPR043170]", "Plakin repeat superfamily [IPR035915]", "Poly(ADP-ribose) polymerase, regulatory domain superfamily [IPR036616]", "Polyketide synthase, dehydratase domain superfamily [IPR042104]", "Polymerase/histidinol phosphatase-like [IPR016195]", "Polyribonucleotide nucleotidyltransferase, RNA-binding domain superfamily [IPR036456]", "Porin domain superfamily [IPR023614]", "Porphobilinogen deaminase, C-terminal domain superfamily [IPR036803]", "Pre-ATP-grasp domain superfamily [IPR016185]", "Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding domain superfamily [IPR042516]", "Prefoldin [IPR009053]", "Profilin superfamily [IPR036140]", "Prolyl-tRNA synthetase, class II [IPR017449]", "Proteasomal ubiquitin receptor Rpn13/ADRM1, Pru domain superfamily [IPR038633]", "Proteasome activator PA28, C-terminal domain superfamily [IPR036997]", "Proteasome activator PA28, N-terminal domain superfamily [IPR036996]", "Proteasome activator superfamily [IPR036252]", "Proteasome assembly chaperone 2 superfamily [IPR038389]", "Protein arginine methyltransferase NDUFAF7 superfamily [IPR038375]", "Protein kinase-like domain superfamily [IPR011009]", "Protein translocase SecE domain superfamily [IPR023391]", "Protein-tyrosine phosphatase-like [IPR029021]", "Prp8 RNase domain IV, fingers region [IPR043173]", "Prp8 RNase domain IV, palm region [IPR043172]", "Pseudouridine synthase I, TruA, C-terminal [IPR020095]", "Pseudouridine synthase TruA/RsuA/RluB/E/F, N-terminal [IPR020094]", "Pseudouridine synthase, TruD, catalytic domain [IPR042214]", "Pseudouridine synthase, catalytic domain superfamily [IPR020103]", "Pterin 4 alpha carbinolamine dehydratase superfamily [IPR036428]", "PurM-like, C-terminal domain superfamily [IPR036676]", "PurM-like, N-terminal domain superfamily [IPR036921]", "Putative DNA-binding domain superfamily [IPR009061]", "Pyridoxal phosphate-dependent transferase [IPR015424]", "Pyridoxal phosphate-dependent transferase, major domain [IPR015421]", "Pyridoxal phosphate-dependent transferase, small domain [IPR015422]", "Pyruvate kinase, C-terminal domain superfamily [IPR036918]", "Pyruvate kinase, insert domain superfamily [IPR015806]", "Pyruvate kinase-like domain superfamily [IPR040442]", "Pyruvate kinase-like, insert domain superfamily [IPR011037]", "Pyruvate/Phosphoenolpyruvate kinase-like domain superfamily [IPR015813]", "Quinoprotein alcohol dehydrogenase-like superfamily [IPR011047]", "Quinoprotein amine dehydrogenase, beta chain-like [IPR011044]", "R3H domain superfamily [IPR036867]", "RGS domain superfamily [IPR036305]", "RNA 3'-terminal phosphate cyclase domain superfamily [IPR037136]", "RNA 3'-terminal phosphate cyclase, insert domain superfamily [IPR036553]", "RNA 3'-terminal phosphate cyclase/enolpyruvate transferase, alpha/beta [IPR013792]", "RNA polymerase Rpb1, clamp domain superfamily [IPR044893]", "RNA polymerase Rpb1, domain 3 superfamily [IPR042102]", "RNA polymerase Rpb1, domain 7 superfamily [IPR038593]", "RNA polymerase Rpb1, funnel domain superfamily [IPR038120]", "RNA polymerase Rpb2, OB-fold [IPR014724]", "RNA polymerase Rpb2, domain 2 superfamily [IPR037034]", "RNA polymerase Rpb7-like, N-terminal domain superfamily [IPR036898]", "RNA polymerase, RBP11-like subunit [IPR036603]", "RNA-binding S4 domain superfamily [IPR036986]", "RNA-binding domain superfamily [IPR035979]", "RPN13, DEUBAD domain superfamily [IPR038108]", "RUN domain superfamily [IPR037213]", "Rab geranylgeranyltransferase, alpha subunit, insert-domain superfamily [IPR036254]", "Rab-GTPase-TBC domain superfamily [IPR035969]", "Ran-GTPase activating protein 1, C-terminal domain superfamily [IPR036720]", "Ras guanine nucleotide exchange factor domain superfamily [IPR023578]", "Ras guanine-nucleotide exchange factor, catalytic domain superfamily [IPR036964]", "Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II [IPR009091]", "Regulatory factor, effector binding domain superfamily [IPR011256]", "Rel homology domain (RHD), DNA-binding domain superfamily [IPR037059]", "Rho GDP-dissociation inhibitor domain superfamily [IPR024792]", "Rho GTPase activation protein [IPR008936]", "Rhodanese-like domain superfamily [IPR036873]", "Rhomboid-like superfamily [IPR035952]", "Riboflavin synthase-like beta-barrel [IPR017938]", "Ribokinase-like [IPR029056]", "Ribonuclease H superfamily [IPR036397]", "Ribonuclease H-like superfamily [IPR012337]", "Ribonuclease H1, N-terminal domain superfamily [IPR037056]", "Ribonuclease HII, helix-loop-helix cap domain superfamily [IPR023160]", "Ribonuclease III, endonuclease domain superfamily [IPR036389]", "Ribonuclease T2-like superfamily [IPR036430]", "Ribonuclease Z/Hydroxyacylglutathione hydrolase-like [IPR036866]", "Ribonucleotide reductase R1 subunit, N-terminal [IPR008926]", "Ribonucleotide reductase-like [IPR012348]", "Ribosomal L15/L27a, N-terminal [IPR027386]", "Ribosomal L18e/L15P superfamily [IPR036227]", "Ribosomal RNA-processing protein 8, N-terminal domain [IPR042036]", "Ribosomal protein L1, 3-layer alpha/beta-sandwich [IPR016095]", "Ribosomal protein L1-like [IPR023674]", "Ribosomal protein L10-like domain superfamily [IPR043141]", "Ribosomal protein L10e/L16 superfamily [IPR036920]", "Ribosomal protein L11, C-terminal domain superfamily [IPR036769]", "Ribosomal protein L11/L12, N-terminal domain superfamily [IPR036796]", "Ribosomal protein L13 superfamily [IPR036899]", "Ribosomal protein L14 superfamily [IPR036853]", "Ribosomal protein L15e core domain superfamily [IPR024794]", "Ribosomal protein L19 superfamily [IPR038657]", "Ribosomal protein L19/L19e superfamily [IPR035970]", "Ribosomal protein L19/L19e, domain 1 [IPR015972]", "Ribosomal protein L2, domain 2 [IPR014722]", "Ribosomal protein L2, domain 3 [IPR014726]", "Ribosomal protein L21 superfamily [IPR036948]", "Ribosomal protein L22/L17 superfamily [IPR036394]", "Ribosomal protein L22e superfamily [IPR038526]", "Ribosomal protein L23/L15e core domain superfamily [IPR012678]", "Ribosomal protein L24e/L24 superfamily [IPR038630]", "Ribosomal protein L25/Gln-tRNA synthetase, N-terminal [IPR020056]", "Ribosomal protein L25/Gln-tRNA synthetase, anti-codon-binding domain superfamily [IPR011035]", "Ribosomal protein L27e superfamily [IPR038655]", "Ribosomal protein L28/L24 superfamily [IPR037147]", "Ribosomal protein L29/L35 superfamily [IPR036049]", "Ribosomal protein L3, domain 3, archaeal type superfamily [IPR044892]", "Ribosomal protein L30, ferredoxin-like fold domain superfamily [IPR036919]", "Ribosomal protein L31e domain superfamily [IPR023621]", "Ribosomal protein L32e superfamily [IPR036351]", "Ribosomal protein L35A superfamily [IPR038661]", "Ribosomal protein L36e domain superfamily [IPR038097]", "Ribosomal protein L37ae/L37e [IPR011331]", "Ribosomal protein L38e superfamily [IPR038464]", "Ribosomal protein L4 domain superfamily [IPR023574]", "Ribosomal protein L5 domain superfamily [IPR022803]", "Ribosomal protein L6, alpha-beta domain superfamily [IPR036789]", "Ribosomal protein L7/L12, C-terminal/adaptor protein ClpS-like [IPR014719]", "Ribosomal protein L7/L12, oligomerisation domain superfamily [IPR036235]", "Ribosomal protein L9, N-terminal domain superfamily [IPR036935]", "Ribosomal protein L9/RNase H1, N-terminal [IPR009027]", "Ribosomal protein P1/P2, N-terminal domain [IPR038716]", "Ribosomal protein S10 domain superfamily [IPR036838]", "Ribosomal protein S11 superfamily [IPR036967]", "Ribosomal protein S13-like, H2TH [IPR010979]", "Ribosomal protein S17e-like superfamily [IPR036401]", "Ribosomal protein S2, flavodoxin-like domain superfamily [IPR023591]", "Ribosomal protein S21e superfamily [IPR038579]", "Ribosomal protein S3, C-terminal domain superfamily [IPR036419]", "Ribosomal protein S4e, central domain superfamily [IPR038237]", "Ribosomal protein S5 domain 2-type fold [IPR020568]", "Ribosomal protein S5 domain 2-type fold, subgroup [IPR014721]", "Ribosomal protein S7 domain superfamily [IPR036823]", "Ribosomal protein S8 superfamily [IPR035987]", "Ribosomal protein S8e subdomain, eukaryotes [IPR042563]", "Ribosome maturation protein SBDS, N-terminal domain superfamily [IPR036786]", "Ribosome maturation protein Sdo1/SBDS, central domain superfamily [IPR037188]", "Ribosome-associated complex head domain superfamily [IPR042569]", "Ribulose-phosphate binding barrel [IPR011060]", "Ricin B-like lectins [IPR035992]", "RmlC-like cupin domain superfamily [IPR011051]", "RmlC-like jelly roll fold [IPR014710]", "Rossmann-like alpha/beta/alpha sandwich fold [IPR014729]", "Rudiment single hybrid motif [IPR011054]", "RutC-like superfamily [IPR035959]", "RuvA domain 2-like [IPR010994]", "RuvBL1/2, DNA/RNA binding domain [IPR042487]", "S-adenosyl-L-methionine-dependent methyltransferase [IPR029063]", "S-adenosylmethionine synthetase superfamily [IPR022636]", "S15/NS1, RNA-binding [IPR009068]", "SAP domain superfamily [IPR036361]", "SAS-6, N-terminal domain superfamily [IPR038558]", "SCP2 sterol-binding domain superfamily [IPR036527]", "SGNH hydrolase superfamily [IPR036514]", "SH2 domain superfamily [IPR036860]", "SH3-like domain superfamily [IPR036028]", "SKP1-like, dimerisation domain superfamily [IPR036296]", "SKP1/BTB/POZ domain superfamily [IPR011333]", "SLED domain superfamily [IPR038348]", "SMAD/FHA domain superfamily [IPR008984]", "SMCs flexible hinge superfamily [IPR036277]", "SNARE [IPR010989]", "SNF2-like, N-terminal domain superfamily [IPR038718]", "SNase-like, OB-fold superfamily [IPR035437]", "SOS response associated peptidase-like [IPR036590]", "SPOC-like, C-terminal domain superfamily [IPR016194]", "SRA-YDG superfamily [IPR036987]", "SRCR-like domain superfamily [IPR036772]", "SRP/SRP receptor, N-terminal [IPR036225]", "SRP68, N-terminal domain superfamily [IPR038253]", "SSRP1 domain superfamily [IPR038167]", "START-like domain superfamily [IPR023393]", "STAT transcription factor, DNA-binding, N-terminal [IPR012345]", "STAT transcription factor, N-terminal domain superfamily [IPR036535]", "STAT transcription factor, coiled coil [IPR015988]", "STAT1, C-terminal domain superfamily [IPR038295]", "SUI1 domain superfamily [IPR036877]", "SWAP/Surp superfamily [IPR035967]", "SWIB/MDM2 domain superfamily [IPR036885]", "Saposin-like [IPR011001]", "Scaffold protein Nfu/NifU, N-terminal domain superfamily [IPR036498]", "Scavenger mRNA decapping enzyme, N-terminal [IPR011145]", "Schlafen, AlbA_2 domain superfamily [IPR038461]", "ScpA-like, C-terminal [IPR023093]", "Sec1-like superfamily [IPR036045]", "Sec1-like, domain 1 [IPR043154]", "Sec1-like, domain 2 [IPR027482]", "Sec1-like, domain 3a [IPR043127]", "Sec23/Sec24 helical domain superfamily [IPR036175]", "Sec7 domain superfamily [IPR035999]", "Sec7, C-terminal domain superfamily [IPR023394]", "SecY domain superfamily [IPR023201]", "Serine carboxypeptidase S28, SKS domain [IPR042269]", "Serine-tRNA synthetase, type1, N-terminal domain superfamily [IPR042103]", "Serpin superfamily [IPR036186]", "Serpin superfamily, domain 1 [IPR042178]", "Serpin superfamily, domain 2 [IPR042185]", "Signal recognition particle SRP54, N-terminal domain superfamily [IPR042101]", "Signal recognition particle, SRP54 subunit, M-domain superfamily [IPR036891]", "Signal recognition particle, SRP9/SRP14 subunit [IPR009018]", "Sin3 associated polypeptide p18 superfamily [IPR042534]", "Single hybrid motif [IPR011053]", "Six-bladed beta-propeller, TolB-like [IPR011042]", "Six-hairpin glycosidase superfamily [IPR008928]", "Six-hairpin glycosidase-like superfamily [IPR012341]", "Smac/DIABLO-like superfamily [IPR009062]", "Sodium/potassium-transporting ATPase subunit beta superfamily [IPR038702]", "Sodium:dicarboxylate symporter superfamily [IPR036458]", "Spermadhesin, CUB domain superfamily [IPR035914]", "Spermidine synthase, tetramerisation domain superfamily [IPR037163]", "Spt6, Death-like domain [IPR042066]", "Stathmin superfamily [IPR036002]", "Sterile alpha motif/pointed domain superfamily [IPR013761]", "Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain superfamily [IPR027477]", "Succinyl-CoA synthetase-like [IPR016102]", "Sulfhydryl oxidase, flavin adenine dinucleotide (FAD) binding domain superfamily [IPR042568]", "TAP42/TAP46-like superfamily [IPR038511]", "TBP domain superfamily [IPR012295]", "TCP-1-like chaperonin intermediate domain superfamily [IPR027410]", "TEL2, C-terminal domain superfamily [IPR038528]", "TFIIS/LEDGF domain superfamily [IPR035441]", "TGS-like [IPR012676]", "TGS-like domain superfamily [IPR023192]", "TMEM14 superfamily [IPR044890]", "TRAF-like [IPR008974]", "TRF2-interacting telomeric protein/Rap1, C-terminal domain superfamily [IPR038104]", "TROVE domain superfamily [IPR037214]", "Talin, central domain superfamily [IPR036476]", "Tautomerase/MIF superfamily [IPR014347]", "Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid [IPR008930]", "Tetrapyrrole methylase superfamily [IPR035996]", "Tetrapyrrole methylase, subdomain 1 [IPR014777]", "Tetrapyrrole methylase, subdomain 2 [IPR014776]", "Tetraspanin, EC2 domain superfamily [IPR008952]", "Tetratricopeptide-like helical domain superfamily [IPR011990]", "Tex-like domain superfamily [IPR023323]", "Tex-like protein, HTH domain superfamily [IPR023319]", "Thiamin diphosphate-binding fold [IPR029061]", "Thiolase-like [IPR016039]", "Thioredoxin-like superfamily [IPR036249]", "Threonyl/alanyl tRNA synthetase, class II-like, putative editing domain superfamily [IPR018163]", "Thymidylate synthase/dCMP hydroxymethylase superfamily [IPR036926]", "Tim10-like domain superfamily [IPR035427]", "Transcription elongation factor S-II, central domain superfamily [IPR036575]", "Transcription termination and cleavage factor, C-terminal domain superfamily [IPR038192]", "Transcriptional regulator TACO1-like, domain 3 [IPR026564]", "Transferrin receptor-like, dimerisation domain superfamily [IPR036757]", "Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II [IPR009014]", "Translation Initiation factor eIF- 4e-like [IPR023398]", "Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal [IPR009001]", "Translation elongation factor EF1B/ribosomal protein S6 [IPR014717]", "Translation elongation factor eEF-1beta-like superfamily [IPR036219]", "Translation initiation factor 2, alpha subunit, C-terminal [IPR024055]", "Translation initiation factor 2, alpha subunit, middle domain superfamily [IPR024054]", "Translation initiation factor 3, subunit 12, N-terminal, eukaryotic [IPR016020]", "Translation initiation factor IF-2, domain 3 superfamily [IPR036925]", "Translation initiation factor IF2/IF5, N-terminal [IPR016189]", "Translation initiation factor IF2/IF5, zinc-binding [IPR016190]", "Translation initiation factor eIF-2B subunit alpha, N-terminal [IPR042528]", "Translation protein SH3-like domain superfamily [IPR008991]", "Translation protein, beta-barrel domain superfamily [IPR009000]", "Translin superfamily [IPR036081]", "Translin, C-terminal [IPR016069]", "Translin, N-terminal [IPR016068]", "Trimeric LpxA-like superfamily [IPR011004]", "Triosephosphate isomerase superfamily [IPR035990]", "TspO/MBR-related superfamily [IPR038330]", "Tubulin binding cofactor A superfamily [IPR036126]", "Tubulin, C-terminal [IPR023123]", "Tubulin/FtsZ, C-terminal [IPR008280]", "Tubulin/FtsZ, GTPase domain superfamily [IPR036525]", "Tubulin/FtsZ-like, C-terminal domain [IPR037103]", "UBA-like superfamily [IPR009060]", "UDP-glucose/GDP-mannose dehydrogenase, C-terminal domain superfamily [IPR036220]", "UROD/MetE-like superfamily [IPR038071]", "Ubiquitin activating enzyme, alpha domain superfamily [IPR023318]", "Ubiquitin-activating enzyme E1, C-terminal domain superfamily [IPR038252]", "Ubiquitin-activating enzyme E1, FCCH domain superfamily [IPR042302]", "Ubiquitin-activating enzyme E1, SCCH domain [IPR042063]", "Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 1 [IPR042449]", "Ubiquitin-activating enzyme [IPR035985]", "Ubiquitin-conjugating enzyme/RWD-like [IPR016135]", "Ubiquitin-like domain superfamily [IPR029071]", "Ufd1-like, Nn domain [IPR042299]", "Ureohydrolase domain superfamily [IPR023696]", "V-type ATP synthase c/d subunit, domain 3 superfamily [IPR044911]", "V-type ATP synthase subunit c/d subunit superfamily [IPR036079]", "V-type ATPase subunit C/d [IPR035067]", "V-type ATPase subunit E, C-terminal domain superfamily [IPR038495]", "VASP tetramerisation domain superfamily [IPR038023]", "VKOR domain superfamily [IPR038354]", "VPS9 domain superfamily [IPR037191]", "Vacuolar ATP synthase subunit C superfamily [IPR036132]", "Vacuolar protein sorting-associated protein 33, domain 3b [IPR043155]", "Vacuolar protein sorting-associated protein 35, C-terminal [IPR042491]", "Vacuolar protein sorting-associated protein IST1-like [IPR042277]", "Valyl-tRNA synthetase, tRNA-binding arm superfamily [IPR037118]", "Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain [IPR009008]", "Vanillyl-alcohol oxidase, C-terminal subdomain 2 [IPR016171]", "Vitamin B12-dependent methionine synthase, activation domain superfamily [IPR037010]", "Vps16, C-terminal domain superfamily [IPR038132]", "Vps53, C-terminal domain superfamily [IPR038260]", "WD40-repeat-containing domain superfamily [IPR036322]", "WD40/YVTN repeat-like-containing domain superfamily [IPR015943]", "WGR domain superfamily [IPR036930]", "WW domain superfamily [IPR036020]", "WWE domain superfamily [IPR037197]", "Winged helix DNA-binding domain superfamily [IPR036390]", "Winged helix-like DNA-binding domain superfamily [IPR036388]", "XPC-binding domain superfamily [IPR036353]", "YebC-like [IPR029072]", "YjeF N-terminal domain superfamily [IPR036652]", "YqgF/RNase H-like domain superfamily [IPR037027]", "ZPR1, A/B domain [IPR042451]", "ZPR1, zinc finger domain [IPR042452]", "Zinc finger C2H2 superfamily [IPR036236]", "Zinc finger, CCCH-type superfamily [IPR036855]", "Zinc finger, CCHC-type superfamily [IPR036875]", "Zinc finger, FYVE/PHD-type [IPR011011]", "Zinc finger, PARP-type superfamily [IPR036957]", "Zinc finger, RING/FYVE/PHD-type [IPR013083]", "Zinc finger, RanBP2-type superfamily [IPR036443]", "Zinc finger, Sec23/Sec24-type superfamily [IPR036174]", "Zinc finger, ZZ-type superfamily [IPR043145]", "Zinc-binding ribosomal protein [IPR011332]", "dUTPase-like superfamily [IPR036157]", "eRF1, domain 1 [IPR024049]", "eRF1, domain 2 superfamily [IPR042226]", "p53-like tetramerisation domain superfamily [IPR036674]", "p53-like transcription factor, DNA-binding [IPR008967]", "p53/RUNT-type transcription factor, DNA-binding domain superfamily [IPR012346]", "ssDNA-binding transcriptional regulator [IPR009044]", "tRNA (guanine-N1-)-methyltransferase, N-terminal [IPR029026]", "tRNA methyltransferase TRM10-type domain superfamily [IPR038459]", "tRNA methyltransferase, Trm1, C-terminal [IPR042296]", "tRNA modification GTPase MnmE domain 2 [IPR027368]", "tRNA-splicing ligase RtcB-like superfamily [IPR036025]", "von Willebrand factor A-like domain superfamily [IPR036465]"], "available_proteins": ["AAAS", "AAMP", "AARS", "AARS2", "AASDHPPT", "ABCB1", "ABCB7", "ABCD3", "ABCE1", "ABCF1", "ABCF2", "ABCF3", "ABHD10", "ABHD12", "ABHD14B", "ABHD6", "ABI1", "ACAA2", "ACACA", "ACACB", "ACAD9", "ACADM", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACIN1", "ACLY", "ACO2", "ACOT13", "ACOT7", "ACOT9", "ACOX1", "ACOX3", "ACP1", "ACP2", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN2", "ACTN4", "ACTR1A", "ACTR2", "ACTR3", "ADAR", "ADD1", "ADD3", "ADH5", "ADI1", "ADK", "ADNP", "ADPGK", "ADPRHL2", "ADRM1", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGK", "AGL", "AGPS", "AHCY", "AHCYL1", "AHNAK", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AK3", "AKAP1", "AKAP13", "AKAP17A", "AKR1A1", "AKR1B1", "AKR7A2", "AKT2", "ALDH16A1", "ALDH18A1", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALKBH5", "ANAPC1", "ANAPC10", "ANAPC5", "ANAPC7", "ANKLE2", "ANKRD17", "ANLN", "ANP32A", "ANP32B", "ANXA1", "ANXA11", "ANXA2", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP1M1", "AP1S2", "AP2A1", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "APEH", "APEX1", "APEX2", "API5", "APLP2", "APMAP", "APP", "APRT", "AQR", "ARCN1", "ARF4", "ARFGAP1", "ARFGAP2", "ARFIP1", "ARFIP2", "ARHGAP17", "ARHGDIA", "ARHGEF2", "ARID1A", "ARID3B", "ARIH1", "ARIH2", "ARL1", "ARL10", "ARL2", "ARL3", "ARMC10", "ARMC6", "ARMCX3", "ARMT1", "ARPC1A", "ARPC2", "ARPC3", "ARPC4", "ARSA", "ASCC2", "ASCC3", "ASH2L", "ASNA1", "ASNS", "ASPH", "ASPSCR1", "ASRGL1", "ATAD1", "ATAD3A", "ATAD3B", "ATIC", "ATL2", "ATP13A1", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2C1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5H", "ATP5O", "ATP6", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1E1", "ATP6V1H", "ATP7B", "ATXN10", "AURKA", "BAG3", "BAG5", "BAG6", "BAIAP2", "BANF1", "BAZ1A", "BAZ1B", "BCAS3", "BCS1L", "BIRC6", "BLMH", "BLVRA", "BMS1", "BOLA2*", "BOP1", "BPTF", "BRAP", "BRAT1", "BRD1", "BRD2", "BSG", "BTAF1", "BTF3", "BUB1B", "BUB3", "BUD23", "BZW1", "BZW2", "C1QBP", "CAB39", "CACUL1", "CACYBP", "CAD", "CALM3", "CALR", "CALU", "CAMK1", "CAMK2G", "CAND1", "CAND2", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPNS1", "CAPZA1", "CAPZA2", "CAPZB", "CARM1", "CARS", "CASK", "CBL", "CBR1", "CBX1", "CBX2", "CBX3", "CBX5", "CCAR1", "CCAR2", "CCNB1", "CCNB2", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2AP", "CDC20", "CDC23", "CDC25C", "CDC27", "CDC34", "CDC37", "CDC40", "CDC42", "CDC5L", "CDC73", "CDK1", "CDK2", "CDK4", "CDK5", "CDK6", "CDX2", "CEBPZ", "CEPT1", "CERS2", "CETN2", "CFL1", "CFL2", "CHAC2", "CHAF1B", "CHAMP1", "CHD4", "CHERP", "CHID1", "CHKA", "CHM", "CHORDC1", "CHRAC1", "CHUK", "CIAPIN1", "CIP2A", "CIRBP", "CISD2", "CIZ1", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLASP2", "CLCN3", "CLCN7", "CLGN", "CLIC1", "CLIC4", "CLINT1", "CLIP1", "CLNS1A", "CLPB", "CLPP", "CLPX", "CLTC", "CLUH", "CMAS", "CMPK1", "CMTR1", "CNN2", "CNN3", "CNNM4", "CNOT1", "CNOT2", "CNOT3", "CNOT4", "CNOT7", "CNOT9", "CNP", "COL4A3BP", "COLEC12", "COLGALT1", "COMT", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS2", "COPS3", "COPS4", "COPZ1", "COQ3", "COQ8A", "CORO1A", "CORO1C", "CORO7", "COTL1", "COX2", "COX4I1", "COX5A", "COX6C", "COX7A2", "CPD", "CPNE1", "CPNE3", "CPOX", "CPSF1", "CPSF3", "CPSF6", "CPSF7", "CPT2", "CPVL", "CRK", "CRKL", "CRNKL1", "CRTAP", "CRYZ", "CS", "CSDE1", "CSE1L", "CSGALNACT2", "CSK", "CSNK1A1", "CSNK2A1", "CSNK2A2", "CSNK2B", "CSTF1", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTBS", "CTH", "CTNNA1", "CTNNAL1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTPS2", "CTSA", "CTSB", "CTSC", "CTTN", "CTU2", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CWF19L1", "CXADR", "CXorf57", "CYB5B", "CYB5D2", "CYB5R1", "CYB5R3", "CYC1", "CYP20A1", "CYP51A1", "DAP3", "DARS", "DARS2", "DAZAP1", "DBN1", "DBNL", "DCAF1", "DCAF7", "DCAKD", "DCPS", "DCTN1", "DCUN1D4", "DCXR", "DDB1", "DDI2", "DDRGK1", "DDT", "DDX1", "DDX10", "DDX17", "DDX18", "DDX20", "DDX21", "DDX23", "DDX24", "DDX27", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX50", "DDX51", "DDX52", "DDX54", "DDX56", "DDX6", "DENR", "DERL1", "DFFA", "DHCR24", "DHFR", "DHRS1", "DHRS7", "DHX15", "DHX16", "DHX29", "DHX30", "DHX36", "DHX37", "DHX8", "DHX9", "DIABLO", "DIAPH1", "DIAPH2", "DIAPH3", "DIDO1", "DIEXF", "DIMT1", "DIS3", "DKC1", "DLAT", "DLD", "DLST", "DNA2", "DNAAF5", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC2", "DNAJC3", "DNAJC7", "DNAJC8", "DNAJC9", "DNM1L", "DNM2", "DNMT1", "DOCK7", "DOHH", "DPH2", "DPH5", "DPM1", "DPP9", "DPYSL2", "DPYSL5", "DR1", "DRG1", "DRG2", "DSC1", "DSC3", "DSG2", "DSP", "DST", "DSTN", "DTYMK", "DUSP12", "DUSP3", "DUSP9", "DUT", "DYNC1H1", "DYNC1LI1", "DYNC1LI2", "DYNC2H1", "DYNLL1", "ECE1", "ECH1", "ECHS1", "ECI1", "ECI2", "EDC3", "EDC4", "EDF1", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EFHD1", "EFL1", "EFTUD2", "EHD1", "EHD4", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2D", "EIF2S1", "EIF2S2", "EIF3B", "EIF3E", "EIF3G", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A3", "EIF4B", "EIF4E", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "ELAC2", "ELAVL1", "ELMO2", "ELOA", "ELOB", "ELOC", "ELP1", "ELP2", "ELP3", "ELP4", "EMC1", "EMC2", "EMC7", "EMD", "EMG1", "ENAH", "ENDOD1", "ENO1", "ENO2", "EPB41", "EPB41L2", "EPB41L5", "EPHA7", "EPHX1", "EPHX2", "EPPK1", "EPRS", "EPS15", "EPS15L1", "ERAL1", "ERAP1", "ERCC2", "ERH", "ERI1", "ERLIN1", "ERLIN2", "ERO1A", "ERP29", "ESD", "ESF1", "ESYT1", "ETF1", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXO1", "EXOC2", "EXOC3", "EXOC7", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "EZR", "FAF1", "FAF2", "FAH", "FAHD1", "FAM129B", "FAR1", "FARSA", "FARSB", "FASN", "FBL", "FBXO22", "FBXO7", "FCGRT", "FDFT1", "FDPS", "FEN1", "FH", "FHOD1", "FIS1", "FKBP10", "FKBP14", "FKBP4", "FKBP5", "FKBP7", "FKBP8", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FMR1", "FN3KRP", "FNTB", "FOXRED1", "FRG1", "FSCN1", "FTO", "FTSJ3", "FUBP1", "FUBP3", "FUCA1", "FUCA2", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GADD45GIP1", "GAK", "GALK1", "GALM", "GALNT1", "GALNT2", "GALNT7", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GBA", "GBF1", "GCAT", "GCDH", "GCLC", "GCLM", "GCN1", "GDI1", "GDI2", "GDPD1", "GEMIN5", "GET4", "GFM1", "GFPT1", "GGCT", "GGCX", "GGH", "GIGYF2", "GINS3", "GINS4", "GLA", "GLB1", "GLDC", "GLO1", "GLOD4", "GLRX", "GLRX3", "GLRX5", "GLS", "GLUD1", "GLYR1", "GM2A", "GMFB", "GMPPB", "GMPS", "GNA13", "GNAI1", "GNAI2", "GNAI3", "GNL1", "GNL2", "GNL3", "GNL3L", "GNPDA1", "GNS", "GOPC", "GORASP2", "GOT1", "GOT2", "GPD2", "GPI", "GPKOW", "GPS1", "GRB2", "GRHPR", "GRPEL1", "GRSF1", "GRWD1", "GSK3B", "GSPT1", "GSR", "GSS", "GSTK1", "GSTM3", "GSTO1", "GSTZ1", "GTF2I", "GTF3C2", "GTF3C3", "GTF3C4", "GTPBP1", "GTPBP10", "GTPBP3", "GTPBP4", "GUF1", "GUSB", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACD3", "HACL1", "HADH", "HADHA", "HADHB", "HAT1", "HBS1L", "HCFC1", "HDAC2", "HDGFL2", "HDHD2", "HDHD5", "HDLBP", "HEATR1", "HEATR3", "HEBP1", "HEBP2", "HECTD1", "HECTD3", "HELLS", "HEXA", "HEXB", "HIBADH", "HIBCH", "HIF1AN", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HLTF", "HMBS", "HMCES", "HMGB1", "HMGB2", "HMGB3", "HMGCS1", "HMOX1", "HMOX2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPLL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HNRNPUL2", "HP1BP3", "HPRT1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSDL1", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA13", "HSPA14", "HSPA1B", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPB1", "HSPBP1", "HSPD1", "HSPE1", "HSPH1", "HTATIP2", "HUWE1", "HYOU1", "IARS", "IARS2", "IDE", "IDI1", "IFT27", "IGBP1", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "ILF2", "ILF3", "ILKAP", "ILVBL", "IMPACT", "IMPDH1", "IMPDH2", "INTS11", "INTS14", "INTS7", "INTS9", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IRF2BPL", "IRS4", "ISOC1", "IST1", "ISYNA1", "ITGB1", "ITPA", "IVD", "JUP", "KARS", "KCTD12", "KCTD5", "KDELC2", "KDM1A", "KDM1B", "KDSR", "KHDRBS1", "KHSRP", "KIAA0319L", "KIAA0368", "KIAA0391", "KIF11", "KIF15", "KIF18B", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF4A", "KIF5B", "KIF7", "KIFBP", "KIFC1", "KLC1", "KMT2A", "KNTC1", "KPNA1", "KPNA2", "KPNA3", "KPNB1", "KRR1", "LANCL2", "LAP3", "LARP1", "LARP4", "LARP4B", "LARS", "LARS2", "LASP1", "LDAH", "LDHA", "LDHB", "LEMD2", "LEMD3", "LETM1", "LGALS3", "LGALS3BP", "LIG1", "LIG3", "LIPA", "LLGL1", "LMAN1", "LMAN2", "LMNA", "LMNB1", "LMNB2", "LNPEP", "LONP1", "LPCAT1", "LRBA", "LRPPRC", "LRRC40", "LRRC47", "LRRC57", "LRRC59", "LRWD1", "LSM14B", "LSM2", "LSM6", "LSM7", "LSS", "LTA4H", "LTN1", "LYAR", "LYPLA1", "M6PR", "MACF1", "MAD2L1", "MAGED2", "MAN2A1", "MAN2B1", "MANBA", "MANF", "MAP2K1", "MAPK1", "MAPRE1", "MAPRE2", "MARC1", "MARS", "MAT2A", "MAT2B", "MATR3", "MAVS", "MBD3", "MCAT", "MCCC1", "MCCC2", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MDC1", "MDH1", "MDH2", "MDN1", "ME1", "MECP2", "MED21", "MED25", "MFN2", "MFSD10", "MFSD3", "MFSD5", "MGEA5", "MGST2", "MGST3", "MIA2", "MICU1", "MID1", "MIF", "MINDY3", "MINPP1", "MIPEP", "MKI67", "MKRN2", "MMS19", "MOGS", "MORF4L1", "MORF4L2", "MOSPD2", "MOV10", "MPI", "MPP6", "MPRIP", "MPST", "MRE11", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL14", "MRPL15", "MRPL19", "MRPL21", "MRPL28", "MRPL3", "MRPL38", "MRPL39", "MRPL44", "MRPL45", "MRPL46", "MRPL47", "MRPL48", "MRPL9", "MRPS11", "MRPS2", "MRPS25", "MRPS27", "MRPS5", "MRPS7", "MRPS9", "MRTO4", "MSH2", "MSH3", "MSH6", "MSI2", "MSN", "MSTO1", "MTA1", "MTA2", "MTAP", "MTCH1", "MTCH2", "MTHFD1", "MTHFD1L", "MTHFD2", "MTMR2", "MTMR6", "MTOR", "MTPAP", "MTPN", "MTR", "MTX1", "MTX2", "MVK", "MYBBP1A", "MYH10", "MYH14", "MYH9", "MYL6", "MYO1B", "MYO1C", "MYO1D", "MYO6", "NAA15", "NAA25", "NAA40", "NAA50", "NAE1", "NAF1", "NAGLU", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NAPG", "NARS", "NASP", "NAT10", "NAXE", "NBN", "NCAPD2", "NCAPG", "NCBP1", "NCDN", "NCKIPSD", "NCL", "NCOA5", "NDRG3", "NDUFA10", "NDUFA9", "NDUFAF7", "NDUFS1", "NDUFS3", "NDUFV1", "NDUFV2", "NECAP1", "NECAP2", "NEK9", "NELFE", "NENF", "NFU1", "NHLRC2", "NHP2", "NIFK", "NIPBL", "NKRF", "NLE1", "NLN", "NME1", "NME6", "NME7", "NMT1", "NNT", "NOB1", "NOC2L", "NOC3L", "NOC4L", "NOL10", "NOL11", "NOL9", "NOM1", "NONO", "NOP2", "NOP56", "NOP58", "NOSIP", "NPC2", "NPEPPS", "NPLOC4", "NPM1", "NRDC", "NRP1", "NSD2", "NSDHL", "NSF", "NSFL1C", "NSUN2", "NSUN5", "NT5C2", "NT5C3B", "NT5DC1", "NT5DC2", "NTHL1", "NTMT1", "NTPCR", "NUB1", "NUBP2", "NUCB1", "NUCB2", "NUDC", "NUDCD2", "NUDT1", "NUDT12", "NUDT21", "NUDT5", "NUF2", "NUP133", "NUP153", "NUP155", "NUP188", "NUP210", "NUP214", "NUP37", "NUP43", "NUP50", "NUP98", "NVL", "NXF1", "NXN", "OAT", "OCLN", "OCRL", "OGDH", "OGT", "OLA1", "OPA1", "OSBP", "OSBPL8", "OSBPL9", "OSGEP", "OTUB1", "OXSR1", "P3H1", "P3H4", "P4HA1", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PAFAH1B1", "PAFAH1B2", "PAFAH1B3", "PAK1", "PAK1IP1", "PAK2", "PANK4", "PAPOLA", "PAPSS1", "PARK7", "PARN", "PARP1", "PBDC1", "PBK", "PBRM1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCK2", "PCMT1", "PCYOX1", "PDCD11", "PDCD4", "PDCD5", "PDCD6", "PDCD6IP", "PDCL3", "PDE12", "PDE6D", "PDHA1", "PDHB", "PDIA3", "PDIA4", "PDIA6", "PDK1", "PDK3", "PDLIM1", "PDLIM3", "PDLIM5", "PDLIM7", "PDPR", "PDS5A", "PDS5B", "PDXDC1", "PDXK", "PEBP1", "PECR", "PEF1", "PELO", "PELP1", "PEPD", "PES1", "PEX14", "PEX19", "PFAS", "PFDN2", "PFDN4", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGGT1B", "PGK1", "PGLS", "PGM1", "PGM2", "PGM3", "PGP", "PGRMC1", "PGRMC2", "PHB", "PHB2", "PHF14", "PHF6", "PHF8", "PHGDH", "PHIP", "PHKA1", "PICALM", "PIK3C2A", "PIK3R4", "PIN1", "PIP4K2C", "PIR", "PITHD1", "PITPNB", "PITRM1", "PKM", "PKMYT1", "PKN2", "PLA2G15", "PLAA", "PLBD2", "PLCG1", "PLEC", "PLK1", "PLOD1", "PLOD2", "PLRG1", "PLS3", "PM20D2", "PMPCA", "PMPCB", "PNO1", "PNP", "PNPT1", "POGZ", "POLA1", "POLA2", "POLD1", "POLD3", "POLDIP2", "POLDIP3", "POLE", "POLE3", "POLE4", "POLR1A", "POLR1B", "POLR2A", "POLR2B", "POLR2C", "POLR2G", "POLR3A", "POLR3C", "POLRMT", "PON2", "POR", "PPA1", "PPA2", "PPAT", "PPFIA1", "PPIB", "PPID", "PPIF", "PPIG", "PPIH", "PPIL4", "PPM1G", "PPME1", "PPP1CA", "PPP1CB", "PPP1R10", "PPP1R7", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP4C", "PPP4R1", "PPP5C", "PPP6C", "PPT1", "PPT2", "PQBP1", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PREP", "PREPL", "PRKAR1A", "PRKAR2A", "PRKCD", "PRKCSH", "PRKDC", "PRMT1", "PRMT3", "PRMT5", "PRMT9", "PRPF19", "PRPF3", "PRPF31", "PRPF39", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPS1", "PRPSAP1", "PRPSAP2", "PRRC1", "PSAP", "PSAT1", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD12", "PSMD13", "PSMD2", "PSMD3", "PSMD4", "PSMD6", "PSME1", "PSME2", "PSME3", "PSME4", "PSMG2", "PSPC1", "PTBP1", "PTBP2", "PTCD1", "PTCD3", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK7", "PTPA", "PTPN1", "PTPN11", "PTRH2", "PTRHD1", "PUF60", "PUM3", "PUS1", "PUS7", "PWP1", "PWP2", "PYCR1", "PYCR2", "QARS", "QDPR", "QKI", "QSOX2", "RAB10", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB21", "RAB23", "RAB24", "RAB2A", "RAB35", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RAB8A", "RABEPK", "RABGAP1", "RABGGTA", "RABL6", "RAC1", "RACGAP1", "RACK1", "RAD21", "RAD23A", "RAD23B", "RAD50", "RAE1", "RAI14", "RALA", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP9", "RANGAP1", "RANGRF", "RAP2B", "RAPGEF2", "RARS", "RARS2", "RAVER1", "RB1", "RBBP4", "RBBP6", "RBBP7", "RBM10", "RBM12", "RBM12B", "RBM14", "RBM17", "RBM19", "RBM22", "RBM25", "RBM26", "RBM27", "RBM28", "RBM3", "RBM34", "RBM39", "RBM4", "RBM5", "RBM8A", "RBMX", "RCC1", "RCC2", "RCL1", "RCN1", "RCN2", "RCOR1", "RDH11", "RDH13", "RDX", "RECQL", "RELA", "REPS1", "RETSAT", "REXO4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RHEB", "RHOT1", "RHOT2", "RIDA", "RIF1", "RINT1", "RIOK2", "RMC1", "RMDN3", "RNASEH2A", "RNASET2", "RNF2", "RNF40", "RNH1", "RNPEP", "ROCK1", "ROCK2", "RPA1", "RPA2", "RPAP3", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL3", "RPL30", "RPL31", "RPL32", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPP30", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS3", "RPS4X", "RPS5", "RPS6KA1", "RPS6KA3", "RPS8", "RPS9", "RPSA", "RRM1", "RRM2", "RRP12", "RRP8", "RSF1", "RSL1D1", "RSL24D1", "RSU1", "RTCB", "RUFY1", "RUVBL1", "RUVBL2", "RWDD1", "S100A10", "S100A11", "S100A13", "SAE1", "SAFB", "SAFB2", "SAMHD1", "SAP18", "SAR1A", "SARNP", "SARS", "SARS2", "SART3", "SASS6", "SBDS", "SCCPDH", "SCFD1", "SCML2", "SCO1", "SCO2", "SCP2", "SCPEP1", "SCRIB", "SDCBP", "SDF4", "SDHA", "SDHB", "SDR39U1", "SEC11A", "SEC22B", "SEC23A", "SEC23IP", "SEC24A", "SEC24B", "SEC24C", "SEC24D", "SEC31A", "SEC61A1", "SEC61G", "SEC63", "SEH1L", "SEL1L", "SENP3", "SEPHS1", "SEPT2", "SEPT7", "SEPT9", "SERPINB6", "SERPINH1", "SET", "SF1", "SF3A1", "SF3A2", "SF3B1", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFSWAP", "SGPL1", "SGTA", "SH3BGRL3", "SH3GL1", "SH3GLB1", "SH3PXD2B", "SHCBP1", "SHMT1", "SHMT2", "SHOC2", "SIL1", "SIN3A", "SKIV2L", "SKIV2L2", "SKP1", "SKP2", "SLC16A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A17", "SLC25A19", "SLC25A20", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A4", "SLC25A42", "SLC25A44", "SLC25A5", "SLC25A6", "SLC27A2", "SLC27A4", "SLC29A1", "SLC30A5", "SLC3A2", "SLC4A1AP", "SLC4A7", "SLC9A3R1", "SLFN11", "SLIRP", "SLIT2", "SLK", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCC1", "SMARCC2", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC6", "SMCHD1", "SMU1", "SMYD3", "SND1", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPC", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNX1", "SNX2", "SNX27", "SNX3", "SNX5", "SNX6", "SNX9", "SOD2", "SON", "SORT1", "SPAG9", "SPART", "SPATA5", "SPATA5L1", "SPEN", "SPNS1", "SPR", "SPTAN1", "SPTBN1", "SPTBN2", "SPTLC1", "SPTLC2", "SQLE", "SQSTM1", "SRCAP", "SREK1", "SRI", "SRM", "SRP14", "SRP54", "SRP68", "SRP72", "SRP9", "SRPK1", "SRPRA", "SRPRB", "SRRM1", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF2", "SRSF3", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSRP1", "STAG2", "STAM", "STARD3", "STARD7", "STAT1", "STAT3", "STIP1", "STMN1", "STOM", "STOML2", "STRAP", "STRBP", "STUB1", "STX4", "STX5", "STX7", "STXBP3", "STXBP4", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGP2", "SUGT1", "SUPT16H", "SUPT5H", "SUPT6H", "SUPV3L1", "SYAP1", "SYMPK", "SYNCRIP", "SYNE2", "TACO1", "TAF15", "TAF6L", "TAGLN2", "TALDO1", "TARDBP", "TARS", "TARS2", "TBC1D13", "TBC1D15", "TBC1D4", "TBC1D9B", "TBCA", "TBCB", "TBCD", "TBCE", "TBL2", "TBL3", "TCEA1", "TCERG1", "TCP1", "TDP2", "TDRKH", "TECR", "TELO2", "TERF2IP", "TEX10", "TEX264", "TFAM", "TFCP2", "TFRC", "THADA", "THOC1", "THOC3", "THOC6", "THOP1", "THUMPD3", "THYN1", "TIAL1", "TIGAR", "TIMM13", "TIMM44", "TIMM50", "TIMM8A", "TIMM8B", "TJP1", "TK1", "TKT", "TLN1", "TMED2", "TMED5", "TMED7", "TMEM14C", "TMOD3", "TMPO", "TMPO", "TMPPE", "TMSB4X", "TMTC3", "TMX1", "TMX2", "TMX4", "TNPO1", "TNPO3", "TOE1", "TOLLIP", "TOM1", "TOMM20", "TOMM34", "TOMM40", "TOMM70", "TOP1", "TOP2A", "TOP2B", "TOR1AIP1", "TOR1AIP2", "TOX4", "TP53", "TP53BP2", "TPD52L2", "TPI1", "TPM4", "TPP1", "TPP2", "TPT1", "TRA2A", "TRA2B", "TRAF2", "TRAP1", "TRAPPC3", "TRAPPC4", "TRAPPC5", "TRIM21", "TRIM25", "TRIM28", "TRIM33", "TRIO", "TRIP12", "TRIP13", "TRMT10C", "TRMT1L", "TROVE2", "TRUB1", "TSFM", "TSG101", "TSN", "TSNAX", "TSPAN3", "TSPAN6", "TSPO", "TTC1", "TTC19", "TTC26", "TTC37", "TTC38", "TTC4", "TTK", "TUBB", "TUBB2A", "TUBB2B", "TUBB4A", "TUBB4B", "TUBB6", "TUBGCP2", "TUBGCP3", "TUFM", "TWF1", "TWF2", "TXNDC12", "TXNDC17", "TXNDC5", "TXNDC9", "TXNL1", "TXNRD1", "TYMS", "U2AF2", "U2SURP", "UAP1", "UBA1", "UBA2", "UBA3", "UBA6", "UBAP2L", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2O", "UBE2Q1", "UBE2S", "UBE3C", "UBE4A", "UBR2", "UBR4", "UBR5", "UBR7", "UBTF", "UBXN7", "UCHL5", "UCK2", "UFC1", "UFD1", "UGCG", "UGDH", "UGGT1", "UGP2", "UHRF1", "UMPS", "UNC119B", "UNC45A", "UPF1", "UQCR10", "UQCRC1", "UQCRC2", "UQCRQ", "URB1", "UROD", "USO1", "USP10", "USP11", "USP14", "USP24", "USP28", "USP34", "USP39", "USP47", "USP48", "USP5", "USP7", "USP8", "USP9X", "UTP15", "UTP18", "UTP20", "UTP4", "UTP6", "UTRN", "VAMP7", "VAPA", "VAPB", "VARS1", "VAT1", "VBP1", "VCL", "VCP", "VDAC1", "VDAC2", "VDAC3", "VKORC1L1", "VPS16", "VPS26A", "VPS29", "VPS33B", "VPS35", "VPS4A", "VPS4B", "VPS51", "VPS53", "VRK1", "WAPL", "WARS", "WDHD1", "WDR1", "WDR12", "WDR18", "WDR3", "WDR33", "WDR36", "WDR4", "WDR41", "WDR43", "WDR5", "WDR6", "WDR61", "WDR75", "WDR77", "WDR91", "WFS1", "WIPI2", "WIZ", "XAB2", "XPNPEP1", "XPNPEP3", "XPO1", "XPO4", "XPO5", "XPO7", "XPOT", "XRCC5", "XRCC6", "YARS", "YARS2", "YBX1", "YKT6", "YLPM1", "YME1L1", "YRDC", "YTHDC2", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2", "ZC3H15", "ZC3H18", "ZC3H4", "ZC3HAV1", "ZCCHC11", "ZCCHC3", "ZFR", "ZFYVE16", "ZNF280C", "ZNF638", "ZPR1"], "leading_proteins": ["ABCB1", "ABHD10", "ADD3", "ADI1", "AGL", "ANKLE2", "AP1B1", "APP", "ATP13A1", "ATP1A1", "ATP2A2", "ATP2C1", "ATP7B", "BSG", "CERS2", "CIRBP", "CLCN3", "CNOT4", "COPG1", "CPVL", "CSGALNACT2", "CTBS", "CTSA", "CTSB", "CXADR", "CYB5B", "CYP51A1", "DNAJA3", "DSC3", "DUSP9", "ECE1", "ECI2", "ELOA", "ELP3", "EMC1", "EPHA7", "EWSR1", "FCGRT", "FLOT1", "FLOT2", "FMR1", "FNTB", "FOXRED1", "FTO", "FUBP1", "FUBP3", "FUCA1", "FUCA2", "FUS", "FXR1", "FXR2", "GAA", "GALNT1", "GALNT2", "GDPD1", "GINS3", "GLA", "GLB1", "GMPPB", "GNL3L", "GUSB", "HDGFL2", "HEXA", "HEXB", "HIF1AN", "HLA-A", "HLA-B", "HLA-C", "HMOX2", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPR", "HSD17B4", "HSDL2", "IGF2R", "KCTD12", "KCTD5", "KDM1B", "KHDRBS1", "KHSRP", "KIAA0319L", "LDAH", "LGALS3BP", "LNPEP", "LSS", "LTA4H", "MAN2B1", "MANBA", "MFSD3", "MGST2", "MOSPD2", "MRPL1", "MRPL14", "MRPL38", "MTCH1", "NAA40", "NAF1", "NAGLU", "NDUFS1", "NENF", "NLN", "NNT", "NPC2", "NPEPPS", "NT5C3B", "OCLN", "OLA1", "OTUB1", "PARN", "PCYOX1", "PFN2", "PGRMC2", "PHKA1", "PITRM1", "PLA2G15", "PMPCA", "POR", "PPT1", "PRCP", "PREB", "PRKAR1A", "PSIP1", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSME2", "PSME3", "PUF60", "PWP2", "RAD23A", "RAVER1", "RBM12B", "RBM4", "RBMX", "RPL37", "RPL37A", "RSL1D1", "SCFD1", "SCPEP1", "SLC16A1", "SLC25A10", "SLC25A11", "SLC25A15", "SLC25A19", "SLC25A20", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A4", "SLC25A42", "SLC25A44", "SLC25A5", "SLC25A6", "SLC29A1", "SPNS1", "SQLE", "STARD7", "STOM", "STX7", "STXBP3", "SYNCRIP", "TAF15", "TCEA1", "TIAL1", "TIMM50", "TSNAX", "TSPAN6", "UGCG", "VAPA", "VDAC1", "VDAC2", "WDR75", "YTHDC2"]} \ No newline at end of file diff --git a/interpro_ptm/advanced/idx2term.json b/interpro_ptm/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..9e26dfeeb6e641a33dae4961196235bdb965b21b --- /dev/null +++ b/interpro_ptm/advanced/idx2term.json @@ -0,0 +1 @@ +{} \ No newline at end of file diff --git a/interpro_ptm/basic/idx2term.json b/interpro_ptm/basic/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..9e26dfeeb6e641a33dae4961196235bdb965b21b --- /dev/null +++ b/interpro_ptm/basic/idx2term.json @@ -0,0 +1 @@ +{} \ No newline at end of file diff --git a/interpro_ptm/consensus.joblib b/interpro_ptm/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..5b6dc162021fd732d6879f1ef0564875688deeaf --- /dev/null +++ b/interpro_ptm/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:ef2bf7203cc7c48dd3781df969873404a5b26ecb1f8fca77b6ab7acc531ee4ed +size 58237 diff --git a/interpro_ptm/df_merge.tsv b/interpro_ptm/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..c57981107d970e936c6c67aa07afef8fff633223 --- /dev/null +++ b/interpro_ptm/df_merge.tsv @@ -0,0 +1 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 diff --git a/interpro_ptm/metrics.json b/interpro_ptm/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..3dee067fc227b3fd1fd63c7765e352ab6cf9cff8 --- /dev/null +++ b/interpro_ptm/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2644, + "annotations_size": 4, + "title": "Average number of proteins per term", + "value": 2.0 +} \ No newline at end of file diff --git a/interpro_ptm/paths.json b/interpro_ptm/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..746cae685e91b4a1028806c5ba084a51dd9b9d5f --- /dev/null +++ b/interpro_ptm/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/interpro_ptm/fragment/C197/C197_val_log2fc"} \ No newline at end of file diff --git a/interpro_ptm/result.tsv b/interpro_ptm/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..90afd7733f7d91b76186cfc69b9cfaf3051a574b --- /dev/null +++ b/interpro_ptm/result.tsv @@ -0,0 +1,2 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +P-type ATPase, phosphorylation site [IPR018303] 0.7790829859795405 1.7320628259576831 0.0832623770267044 0.2937146130930299 0.1665247540534089 5 P05023,P35670,Q9HD20,P16615 4 diff --git a/interpro_ptm/selections.json b/interpro_ptm/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..787489b17b2f2b0779163a7157907feaef5d726e --- /dev/null +++ b/interpro_ptm/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["EGF-type aspartate/asparagine hydroxylation site [IPR000152]", "P-type ATPase, phosphorylation site [IPR018303]", "Phosphopantetheine attachment site [IPR006162]", "Translation elongation factor, IF5A, hypusine site [IPR019769]"], "available_proteins": ["ATP13A1", "ATP1A1", "ATP2A2", "ATP2C1", "ATP7B", "EIF5A", "FASN", "SLIT2"], "leading_proteins": ["ATP13A1", "ATP1A1", "ATP2A2", "ATP7B"]} \ No newline at end of file diff --git a/interpro_repeat/advanced/idx2term.json b/interpro_repeat/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..6dce773863970e13dd9ed6c0019ab4c4e97de280 --- /dev/null +++ b/interpro_repeat/advanced/idx2term.json @@ -0,0 +1 @@ +{"0": "Mitochondrial substrate/solute carrier [IPR018108]"} \ No newline at end of file diff --git a/interpro_repeat/advanced/plot_0.png b/interpro_repeat/advanced/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..ed39b2b2bc5e48972c629717952ab5a5ea8935f1 --- /dev/null +++ b/interpro_repeat/advanced/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:c3c38bba265c58def785ca93d936cab4c3200b81a0f406827d5efd0f9906ce5a +size 184694 diff --git a/interpro_repeat/basic/idx2term.json b/interpro_repeat/basic/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..6dce773863970e13dd9ed6c0019ab4c4e97de280 --- /dev/null +++ b/interpro_repeat/basic/idx2term.json @@ -0,0 +1 @@ +{"0": "Mitochondrial substrate/solute carrier [IPR018108]"} \ No newline at end of file diff --git a/interpro_repeat/basic/plot_0.png b/interpro_repeat/basic/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..19c1d742c5a5d382fc840528eb75e43c5a3ff8a3 --- /dev/null +++ b/interpro_repeat/basic/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:360719cfc747ab1d9781b93930e52ea3220a2d99aafca68015d851900c87107e +size 142453 diff --git a/interpro_repeat/consensus.joblib b/interpro_repeat/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..3a03c5b5a1b22ec55a4f9de5a29b270bd1a8c815 --- /dev/null +++ b/interpro_repeat/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:d3a28ab6a971453550be6f77cf42977b986d2c8d57f0efbd4252768f21587d8c +size 61082 diff --git a/interpro_repeat/df_merge.tsv b/interpro_repeat/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..858e109ac7edb7445d6e3b15fec6247dfd8d4e76 --- /dev/null +++ b/interpro_repeat/df_merge.tsv @@ -0,0 +1,2 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Mitochondrial substrate/solute carrier [IPR018108] 15 20 2.276710837190061 0.0228034989421126 9.148058252427184 20.71359223300971 2.0411027534642088 0.1411881998864352 5.368907349966936 1.8276489510009888 1.309103123363054 0.2428184236965967 0.0174465086842438 1.0 0.0513963234576887 0.0020925837152473 9.016090704967298e-06 diff --git a/interpro_repeat/metrics.json b/interpro_repeat/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..9a73c65185b75e1096071269c887e306debe01a2 --- /dev/null +++ b/interpro_repeat/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2644, + "annotations_size": 73, + "title": "Average number of proteins per term", + "value": 5.041095890410959 +} \ No newline at end of file diff --git a/interpro_repeat/paths.json b/interpro_repeat/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..ab1ecd4f788c362896132075d47603ff40a1802f --- /dev/null +++ b/interpro_repeat/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/interpro_repeat/fragment/C197/C197_val_log2fc"} \ No newline at end of file diff --git a/interpro_repeat/result.tsv b/interpro_repeat/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..e7afa7237b902fd90e9616c5414bd79734e0d87a --- /dev/null +++ b/interpro_repeat/result.tsv @@ -0,0 +1,6 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Mitochondrial substrate/solute carrier [IPR018108] 0.6535802721144071 2.276710837190061 0.0228034989421126 0.814356845734911 0.4762099570918039 20 Q9HC21,P12235,Q9H2D1,P12236,P05141,Q02978,Q86VD7,Q9UBX3,Q00325,Q6NUK1,O43772,Q9Y619,Q96H78,Q9NZJ7,Q70HW3 15 +PFTB repeat [IPR001330] 0.756623769871307 0.7628412480825977 0.4455580781931085 1.0 0.692037015065892 2 P49356 1 +Leucine-rich repeat, typical subtype [IPR003591] 0.3439385056224602 0.177267051346724 0.8592986301170138 1.0 0.9952692637552084 11 O94813 1 +Filamin/ABP280 repeat-like [IPR017868] 0.3204545454545492 0.0441199966033321 0.9648087533192976 1.0 1.0 4 O75369,Q14315,Q7Z4H8 3 +Filamin/ABP280 repeat [IPR001298] 0.3204545454545492 0.0441199966033321 0.9648087533192976 1.0 1.0 4 O75369,Q14315,Q7Z4H8 3 diff --git a/interpro_repeat/selections.json b/interpro_repeat/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..e85114523256661d327e8f31b516f2343e2a7000 --- /dev/null +++ b/interpro_repeat/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["Ankyrin repeat [IPR002110]", "Annexin repeat [IPR018502]", "Armadillo [IPR000225]", "Atypical Arm repeat [IPR032413]", "BIR repeat [IPR001370]", "Calponin repeat [IPR000557]", "Cation-independent mannose-6-phosphate receptor repeat [IPR000479]", "Chromosome region maintenance repeat [IPR041123]", "Clathrin, heavy chain, propeller repeat [IPR022365]", "Clathrin, heavy chain/VPS, 7-fold repeat [IPR000547]", "Collagen triple helix repeat [IPR008160]", "Cysteine-rich Golgi apparatus protein 1 repeat [IPR001893]", "Cysteine-rich Golgi apparatus protein 1 repeat, eukaryote [IPR017873]", "Exportin-1, repeat 2 [IPR041235]", "Exportin-1, repeat 3 [IPR040485]", "Filamin/ABP280 repeat [IPR001298]", "Filamin/ABP280 repeat-like [IPR017868]", "Fis1, C-terminal tetratricopeptide repeat [IPR028061]", "Fis1, N-terminal tetratricopeptide repeat [IPR028058]", "G-protein beta WD-40 repeat [IPR020472]", "GTF2I-like repeat [IPR004212]", "HAT (Half-A-TPR) repeat [IPR003107]", "HEAT repeat [IPR000357]", "HEAT repeat associated with sister chromatid cohesion protein [IPR026003]", "HEAT, type 2 [IPR021133]", "HUWE1/Rev1, ubiquitin binding region [IPR025527]", "Hexapeptide repeat [IPR001451]", "Hs1/Cortactin [IPR003134]", "Importin repeat 4 [IPR041653]", "Importin repeat 6 [IPR041389]", "Importin repeat [IPR040928]", "KI67R [IPR012568]", "Kelch repeat type 1 [IPR006652]", "Kelch repeat type 2 [IPR011498]", "Kinesin light chain repeat [IPR015792]", "Leucine rich repeat 4 [IPR025875]", "Leucine-rich repeat [IPR001611]", "Leucine-rich repeat, cysteine-containing subtype [IPR006553]", "Leucine-rich repeat, typical subtype [IPR003591]", "Low-density lipoprotein (LDL) receptor class A repeat [IPR002172]", "Mbt repeat [IPR004092]", "Microtubule associated protein, tubulin-binding repeat [IPR001084]", "Mitochondrial substrate/solute carrier [IPR018108]", "NHL repeat [IPR001258]", "Nebulin repeat [IPR000900]", "Neuraxin/MAP1B repeat [IPR000102]", "P120R repeat [IPR012586]", "PBS lyase HEAT-like repeat [IPR004155]", "PFTB repeat [IPR001330]", "Paired amphipathic helix [IPR003822]", "Parallel beta-helix repeat [IPR006626]", "Pentatricopeptide repeat [IPR002885]", "Plectin repeat [IPR001101]", "Proteasome/cyclosome repeat [IPR002015]", "Protein of unknown function DM15 [IPR006607]", "Protein prenyltransferase, alpha subunit [IPR002088]", "Proteinase inhibitor I27, calpastatin [IPR001259]", "Pumilio RNA-binding repeat [IPR001313]", "Putative TPR-like repeat [IPR031545]", "Pyrrolo-quinoline quinone repeat [IPR002372]", "RNA helicase p68 repeat [IPR012587]", "RNA polymerase II, heptapeptide repeat, eukaryotic [IPR000684]", "Regulator of chromosome condensation, RCC1 [IPR000408]", "Ribonuclease inhibitor, leucine rich repeat cap [IPR041302]", "Sel1-like repeat [IPR006597]", "Spectrin repeat [IPR002017]", "Spectrin/alpha-actinin [IPR018159]", "Tetratricopeptide repeat 1 [IPR001440]", "Tetratricopeptide repeat 2 [IPR013105]", "Tetratricopeptide repeat [IPR019734]", "Vesicle tethering protein p115, armadillo tether-repeat [IPR041209]", "WD40 repeat [IPR001680]", "Wolframin, Sel1-like repeat [IPR045458]"], "available_proteins": ["AAAS", "AAMP", "ACTN1", "ACTN2", "ACTN4", "AIP", "ANAPC5", "ANAPC7", "ANKRD17", "ANP32A", "ANP32B", "ANXA1", "ANXA11", "ANXA2", "ANXA6", "ANXA7", "AP1B1", "AP2B1", "ARMC6", "ARMCX3", "ARPC1A", "ASPH", "BIRC6", "BOP1", "BRAT1", "BUB3", "CAST", "CDC20", "CDC23", "CDC27", "CDC40", "CHAF1B", "CKAP5", "CLASP1", "CLPB", "CLTC", "CNN2", "CNN3", "COLEC12", "COPA", "COPB2", "CORO1A", "CORO1C", "CORO7", "CRNKL1", "CSTF1", "CSTF3", "CTNNB1", "CTNND1", "CTTN", "DCAF7", "DDX5", "DNAAF5", "DNAJC3", "DNAJC7", "DOHH", "DSP", "DST", "EDC4", "EIF2B5", "EIF3I", "ELP2", "EMC1", "EMC2", "EPPK1", "FIS1", "FKBP4", "FKBP5", "FKBP8", "FLII", "FLNA", "FLNB", "FLNC", "FNTB", "GCN1", "GEMIN5", "GLG1", "GLS", "GMPPB", "GRWD1", "GTF2I", "GTF3C2", "GTF3C3", "HCFC1", 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1.827159812714955e-05 7.125032306985868e-05 0.0017469853347645 +Locomotory behavior 7 24 2.7502318231958984 0.0059553116163608 7.186893203883495 29.01456310679612 0.367578136549174 0.4129867938447028 2.855164467106169 2.964970497634466 1.254834886476281 0.3178953925587394 6.826669039140895e-05 0.0105938135914028 0.002167548947337 0.002095978888674 0.0164186077138823 +Anion transmembrane transport 22 37 2.7383482630270626 0.0061748647745898 18.02912621359223 42.29854368932039 1.9137296804814252 0.1915609440243116 8.771596162415214 5.032004157423188 1.8922368499585025 0.2935375719655638 0.0011976259964271 0.0164824785433421 0.0044166793623189 0.0003763683257436 2.867644240036449e-09 +Inorganic anion transport 16 23 2.7121180286128768 0.0066854783227794 9.900485436893204 25.351941747572816 1.3590123122148194 0.2025490755989976 4.608697956226863 4.352203003870329 1.5972877171217004 0.2769639658120273 0.0004773845082524 0.0003235415753736 0.0005115527825537 0.0002471633761616 7.750528704024836e-07 +Membrane lipid catabolic process 9 12 2.699341298027398 0.0069476884010732 5.854368932038835 11.361650485436892 0.500872843713425 0.1363587272813367 1.9603237645724247 0.9867004907377388 2.113024793917032 0.2289617793743788 2.7698853731876897e-07 0.0001122733832082 1.0236679094826864e-06 1.0378820679868198e-08 7.765261151663103e-09 +Regulation of pattern recognition receptor signaling pathway 6 15 2.632412820249232 0.0084780778201385 4.691747572815534 19.70873786407767 0.80673262224624 0.4173389113947272 2.517825740704142 3.173406084005513 0.919675411949683 0.3119180769844089 0.0124013416230438 0.2588687133858448 0.0216384292134882 0.0037630129831157 0.0295679613042224 +Antigen processing and presentation 6 17 2.62835382552563 0.0085799221138591 6.201456310679611 22.17718446601942 0.8231471183465873 0.4220086818460768 2.970845032857872 3.056135613532617 0.9682333159777928 0.3245513416930483 0.0496610013618657 0.2406936845278361 0.0173242512102645 0.0024554723849656 0.0195107872901531 +Adult locomotory behavior 4 13 2.614831994878692 0.0089271354654014 3.95873786407767 14.822815533980584 0.7389907423501648 0.3383620981823156 1.833016072372531 1.4878680371825237 1.1254592435779416 0.2897204029443448 0.000263141833142 0.0009094910101507 0.000562497610511 0.0026376358858749 0.0118494727859131 +Vacuole organization 11 43 2.602706850534712 0.0092491001554155 14.220873786407768 51.74514563106796 0.8524122478550634 0.3147425083910056 5.370022076358251 7.439112114793103 1.7567175511320523 0.3563110134355993 0.0004170582539588 0.0064011041353566 0.0037368951209636 0.0003790552488406 0.0081420814083846 +Adult behavior 5 17 2.5902026087634376 0.0095919459193005 4.924757281553398 19.364077669902912 0.6031935344655648 0.4116465050786389 2.137657889318908 2.190772988063693 1.071812274679601 0.3090358289458393 0.0003449387965994 0.003696507335194 0.0034703369124038 0.0047615333276254 0.0370324845913321 +Vacuolar acidification 5 9 2.547710659565315 0.0108432363553279 3.4757281553398056 8.922330097087379 1.27407749822917 0.1611429668415415 1.4148632661931722 1.303016071016461 1.4195929612668792 0.2212670077717619 4.431129500144732e-06 0.0032958763634803 0.0006327439593496 2.765770662469611e-06 1.1987894967655104e-05 +Endocytosis 23 91 2.5441610563300148 0.0109540564303427 25.6626213592233 116.14077669902912 0.4088637809343856 0.6347066552957155 9.675324480764845 15.608206311139906 1.1645342915127963 0.3689266363473043 0.0005254372809565 0.0012684774062575 0.0004913754545527 0.000798543924188 0.0185247850760282 +Carbohydrate derivative transport 12 14 2.5414037576720827 0.0110408338049436 7.924757281553398 17.024271844660195 1.3665639952580566 0.1869571280171947 4.210097511648942 2.624454303682939 1.5541767319140831 0.2467993156006303 0.0043344878323294 0.0204708743585679 0.0096938597365547 0.0247625444605767 0.0014700047331845 +Oligosaccharide metabolic process 5 7 2.533665584044339 0.0112876396778736 3.0606796116504853 6.179611650485437 -0.0148577354153068 0.2267163537664357 1.4017006052191363 1.1242135739548185 1.7186048285621385 0.2671195008920222 0.00030448629013 0.0053672672920639 0.0013262573806951 1.3582842958771772e-05 0.0006251087677314 +Behavior 14 62 2.4989241380355818 0.0124570974749684 16.990291262135923 75.04126213592232 0.2909440827671418 0.5405324846032677 5.526186812971979 8.403983472903677 1.109438409605415 0.3578193814797769 0.0018981479708092 0.0401797442881713 0.0151065367348571 0.0060361891455099 0.1621409639316201 +Neuromuscular process controlling balance 4 12 2.491917074046652 0.0127055697825053 3.8810679611650487 11.723300970873789 0.1269749302219408 0.3318237886495486 1.6788029789058698 1.2889149409291965 1.4027465363164735 0.2954189115293261 0.0004252800793608 0.1135912525516411 0.0016986126979642 0.0002861885476851 0.0010098105424835 +Hormone metabolic process 12 28 2.47705331373954 0.0132472112367629 8.95631067961165 28.65776699029126 1.130508313948193 0.2963365150575847 3.9674689274001818 2.5345884681715156 1.346801337886388 0.3240077568826507 0.0005086131635024 0.0112094197529472 0.0023748989920053 0.0005549428323582 0.000224943106111 +Organic acid transmembrane transport 13 24 2.476133554210149 0.0132813886011351 12.37621359223301 29.983009708737864 1.9038035525846064 0.1759244630123113 6.520447095353999 3.550222565141749 1.416714921004232 0.2641413901650407 0.1102036512839536 1.0 0.1793408912067547 0.0444212272681039 2.5823112105880053e-05 +Glycosaminoglycan catabolic process 4 5 2.472175354585304 0.0134293625769519 2.6432038834951457 4.665048543689321 0.5167433573606753 0.1777854895826483 1.1305026922003756 0.6751064263980151 1.6910244329591049 0.2288538535307848 1.299673020794134e-05 0.0012105019492812 2.515038607063009e-06 3.2862197875785204e-06 9.477724444731584e-05 +Glycoside metabolic process 5 9 2.467259277207715 0.0136151732340796 3.283980582524272 8.611650485436893 0.5062828222010527 0.3204164092287125 1.4990079825210394 0.6824144700308834 1.298018080705215 0.2868097664691992 5.137753109661152e-05 4.557535944516599e-05 1.0100053103379697e-05 7.927508175268795e-07 4.318273591764818e-05 +Lipoprotein metabolic process 4 12 2.4540973941753177 0.0141238722311591 5.504854368932039 19.114077669902912 1.0723975558987071 0.2794846862458811 2.648039342123219 3.7213756556771336 1.2556798055308762 0.2951644225033464 0.0349364208357769 0.0078165677457274 0.0089732445190698 0.0551022953292233 0.2293860059300122 +Aminoglycan catabolic process 5 6 2.4519057726345723 0.014210186786681 2.6893203883495147 4.728155339805825 0.5164809724591738 0.1764823388548578 1.1619294817897845 0.7656988020633148 1.69808407883546 0.2279588459746903 1.9275357824133423e-05 0.0014481500629001 3.74476751148508e-06 1.5560435214860637e-07 9.033677057044543e-06 +Antigen processing and presentation of peptide antigen 5 10 2.4515064121846804 0.0142259651831315 4.050970873786408 11.99271844660194 0.9279525789651738 0.3302951212632576 1.9792182503824105 1.8740552023113428 1.0022067378347963 0.2823588878170496 0.0129058913521731 0.151306852499084 0.0041517217414646 0.0012549484261259 0.0053005354814706 +Intracellular lipid transport 5 11 2.43413696987089 0.0149273452613776 3.2475728155339807 12.529126213592232 1.0333463606041455 0.2805251274605093 1.854375285913986 2.478377603832177 1.0146678848168829 0.2521579143644115 0.0118914584472129 0.1471951297158956 0.0398064357050217 0.0001216265378748 0.0008544422426654 +Carbohydrate derivative catabolic process 14 31 2.433943520756527 0.0149353253315116 9.92233009708738 34.20388349514563 -0.0123085756499559 0.2707665028006943 3.843893961107642 3.291233496452993 1.7787241070250257 0.2878972939517332 7.426083592511903e-07 5.87112937759668e-08 1.0386142563532633e-08 9.346675036557078e-08 3.208606305036936e-05 +Long term synaptic potentiation 3 9 2.406849693119099 0.0160907908485967 3.012135922330097 9.730582524271844 0.4069972937780292 0.4936148854997918 1.5319726166057843 1.7661148877091215 0.9317897164603502 0.2968501206773379 0.0036872654417843 0.0188245552589776 0.0666692325567911 0.0213813720021448 0.1628039428893685 +Regulation of carbohydrate catabolic process 1 12 2.404036957327373 0.0162151339025331 3.1480582524271843 14.53883495145631 -0.025088322847414 0.5745798711188883 2.4917185391131262 1.460132525552545 0.8691706241229656 0.2899411078266523 0.1049018443318149 0.0142466262053111 0.0513963234576887 0.2345960405017343 0.5558309849086144 +Regulation of long term synaptic potentiation 3 6 2.3941943325331314 0.016656920788352 2.191747572815534 6.026699029126213 0.6105178624452509 0.3860292464291884 1.2788913032023987 1.4948993461258857 1.1199694698848182 0.3107967468650517 0.0003612855674651 0.0058373227860703 0.0219975904219434 0.0024379570615939 0.0267540631687978 +Regulation of multicellular organism growth 4 12 2.392355633316692 0.0167406125373541 3.679611650485437 14.067961165048544 0.6235984614772049 0.4457844002979414 1.844506891943582 1.9756386993416857 0.857961107337238 0.2839539709235323 0.0139683468541165 0.0121686135974036 0.0045096021611559 0.0520565373494006 0.0255449311307142 +Learning 2 15 2.391833058842607 0.0167644657408936 4.589805825242719 18.93446601941747 0.4051379104506336 0.500788863717711 2.588096905713564 2.8673042134954594 0.95936751956091 0.3128033021759736 0.0759624333860221 0.0041986670986062 0.0275216398495969 0.0824194625829831 0.4202555039331938 +Glycoside catabolic process 5 6 2.3874812424062704 0.0169642684297943 2.995145631067961 5.604368932038835 0.914408298188202 0.1915126053981477 1.4021397407455505 0.554137429771367 1.5051386650706404 0.245673751384095 2.852324428860232e-06 5.743829058688599e-06 5.454643878372586e-07 5.1173118255718285e-09 3.235576349203615e-07 +Cellular ion homeostasis 29 76 2.3780400683603413 0.0174049345403806 24.48543689320388 87.34708737864078 0.921352068115914 0.4223079442129951 9.212290310790763 8.933596252465952 1.5207794649628892 0.4002972861975121 0.0063969777173813 0.0415728131613531 0.1223228606683068 0.0009832494673994 0.0016407926821472 +Amino acid transport 9 16 2.376976205124833 0.017455214094725 7.771844660194175 19.75 0.8410032854505353 0.3449280742441291 4.117377746800764 3.003739578643708 1.287399790463736 0.3206698223659758 0.2647984056095582 1.0 0.4876012483283494 0.2338841850044661 0.0016847631379816 +Alcohol metabolic process 25 74 2.372773335090056 0.0176550946347266 19.300970873786408 81.99029126213593 1.0392616248309592 0.3936245775900834 6.9548962308345 7.403089286448431 1.208378917036781 0.3759976884392474 0.0009208266143643 0.0177063092471413 0.0039375020442376 4.7186904172996896e-05 2.892649499245202e-06 +Glycosphingolipid metabolic process 6 8 2.368219333117006 0.0178739361698141 4.764563106796117 9.184466019417476 0.4485135251287195 0.1553285492394019 1.7516723087054535 1.7320372023153958 1.93068386398988 0.2217231968869004 0.0001029866286304 0.0005142462303242 1.4194050004739812e-05 1.1213911854546629e-05 0.0008544422426654 +Regulation of mononuclear cell migration 4 13 2.367414771362738 0.0179128452520433 4.548543689320389 16.800970873786408 -0.0451470857329185 0.6235913245378032 2.5976226650972936 2.65933034660148 0.8401157368959713 0.2924888202464074 0.0257249292436593 0.0188245552589776 0.0666692325567911 0.0213813720021448 0.0601700233302374 +Mitochondrial respiratory chain complex assembly 11 28 2.3592199060048022 0.0183133998642126 14.427184466019416 38.300970873786405 1.6683402305651691 0.229838901803248 5.648441561419256 5.588363345618 1.6629328950455762 0.3088219725228932 0.3818794160606005 0.3561784256622231 0.2178091494673695 0.0229258137019905 0.0123833213958144 +Cellular carbohydrate catabolic process 3 16 2.358524919955743 0.0183477278516221 4.094660194174757 17.519417475728154 0.0720112229026999 0.5230835350302091 2.73830622849908 1.2452284270055651 0.9511421553520558 0.2982026173853891 0.008306523376722 0.0084566179175882 0.031373049189738 0.0049571663496986 0.0495301536946375 +Neuromuscular process 6 21 2.3583199313169803 0.018357863766484 6.682038834951456 25.487864077669904 0.5107907507501308 0.3958015985368521 2.5973040014911133 3.0533044809467955 1.2106508695866462 0.3144907539964949 0.0026429633093225 0.2731012734555347 0.0036673828223822 0.0010365522124053 0.004314543225402 +Regulation of steroid biosynthetic process 6 10 2.3469533448290023 0.0189276246698986 3.186893203883495 10.259708737864075 0.6168896095149775 0.3174156062343823 1.783561142158544 1.373475469974866 1.265753415239616 0.2847701277650337 0.0174465086842438 1.0 0.3076603852203092 0.063688713570506 0.0020472170292007 +Entry into host 9 29 2.346615551985169 0.0189447908790052 7.968446601941747 31.24514563106796 0.6061616104105989 0.3954837799611526 3.566493820193545 3.4119437173329663 1.31706945612869 0.333413728218646 0.0003935940347687 0.0099984448704361 0.0122106671185157 0.0018302022360233 0.0017021800757447 +Organic anion transport 29 39 2.338369066654804 0.0193681109747643 18.575242718446603 46.57281553398058 1.6158560948583975 0.2692356013040078 9.46386426798458 5.9518324529926545 1.7470285445738305 0.3371920110610632 0.1570082879195197 0.5027324490187645 0.4042257707765572 0.060695411188978 1.4992026131371546e-06 +Regulation of nervous system process 4 10 2.331416994293026 0.0197313822812927 2.6941747572815533 11.186893203883496 0.709685710886722 0.4267375683332639 1.6891041598029932 2.2483053074671338 0.9287991925104498 0.3050882814355576 0.0067255619426256 0.2220822570468345 0.0890100643743446 0.0082403851981354 0.105877285302659 +Amino acid transmembrane transport 6 12 2.302103531674525 0.0213293343126488 6.213592233009709 14.228155339805824 0.7890307267204019 0.3318923540291705 3.493823914060917 1.9561661273054285 1.3497309258640615 0.3227865040448734 0.497818985601299 1.0 1.0 0.3157753203157507 0.007013421835749 +Membrane protein proteolysis 5 11 2.295701962074673 0.0216929281936983 4.138349514563107 11.781553398058252 1.0093176076341577 0.3069750059979975 2.078037067185485 1.3902746514167437 1.0484204695389652 0.2877212872591311 0.0200095143839186 0.1755724648168266 0.0563311776114605 0.0720513532108381 0.0118494727859131 +Organophosphate ester transport 11 22 2.289346345668245 0.022059236917802 10.29126213592233 27.364077669902912 1.4948680330369015 0.1889391065154625 4.84293313185659 4.31957284765524 1.6451867819665518 0.2532208690981375 0.0057369907724243 0.0551599902794207 0.0069551143734033 0.002958524345255 0.000386465762899 +Regulation of receptor mediated endocytosis 4 19 2.28585338029016 0.0222628375858267 4.793689320388349 24.031553398058257 0.302771523245338 0.6139564689831747 2.578601069629366 3.990458828834646 0.7718297586481511 0.306515207758586 0.0924164012365507 0.0490886173861251 0.1588529428511447 0.0333870553509734 0.288394033884563 +Nadh dehydrogenase complex assembly 4 19 2.2776475131299456 0.022747587241233 9.266990291262136 26.96359223300971 1.1245271541492263 0.3013677937017552 4.122702675359976 4.029157649894909 1.4460543016521823 0.3224564676521605 0.5664556579549518 0.2406936845278361 0.4242240140575919 0.048897845662748 0.0566002365685155 +Organic acid transport 19 37 2.2727030532505945 0.0230440805436984 16.199029126213592 46.1626213592233 1.6912598339530378 0.23494744574913 7.685833584742487 5.405881453891157 1.4084922190667013 0.315570201131532 0.0491178022143492 1.0 0.1449031461986719 0.0182037584987757 9.092227468864567e-06 +Dicarboxylic acid transport 7 11 2.263139593385849 0.0236270855211551 5.718446601941747 16.097087378640776 1.1205667041867788 0.2998586575349944 3.584398436287638 2.226340822602054 1.0973546365412417 0.2986830136605488 0.4595569697651365 1.0 0.3339976348230559 0.2707185745648809 0.0149334923888548 +Reactive nitrogen species metabolic process 6 14 2.262070663155023 0.0236930378046564 3.9805825242718447 16.550970873786408 0.5187061899010498 0.4616229774504417 2.0608725766457097 1.6501909360329357 0.9419567550357958 0.306935586730602 0.0257249292436593 0.0188245552589776 0.0666692325567911 0.0213813720021448 0.0048404074215544 +Protein transmembrane import into intracellular organelle 8 12 2.2596014011711607 0.0238460005661309 4.951456310679611 13.45631067961165 1.503963012554726 0.1758225015375162 2.735521961789203 1.4944992929031071 1.2360761671845495 0.245991671368161 0.0698897647338063 0.0090330503435184 0.0334071197556988 0.1637924032376012 0.0027564644815256 +Connective tissue development 3 19 2.2530565528562434 0.0242555834252735 6.759708737864078 24.91747572815534 0.897701915164713 0.400129048313066 2.7453452066208146 3.8608044632925673 0.8993390896039578 0.3237981500894625 0.2843924350616756 0.462328834210194 0.1252248136047773 0.3757188474005738 0.4269877292365965 +L amino acid transport 5 11 2.236089966544668 0.0253458785546043 5.114077669902913 11.91504854368932 0.7755289387861473 0.3283794523692901 2.998235059113201 1.3256494094845783 1.3058948249973923 0.3189923022900864 0.3922283436414795 1.0 1.0 0.1988041978590851 0.0053005354814706 +Leukocyte mediated cytotoxicity 7 14 2.2161935163499487 0.0266782517368315 4.351941747572815 13.985436893203884 0.4021439577883799 0.5004679143122512 2.4135380942775657 1.8380502421368885 0.9762325275008988 0.3133102965191064 0.1435485262919318 1.0 0.3593428278464597 0.0048857385669874 0.0014700047331845 +Sterol metabolic process 18 36 2.2146848980152365 0.0267817001513921 11.932038834951456 38.44660194174757 1.1656335789111734 0.2523239777622673 4.346099994655023 4.0619669904912925 1.6676089351046874 0.3062687621764124 3.053743661344071e-05 0.0007162824744306 1.6342529313586228e-05 1.1325122383507624e-07 3.8895733506401575e-10 +Positive regulation of endocytosis 3 14 2.2104347496649885 0.0270750043407714 4.560679611650485 19.640776699029125 0.3893750024867851 0.549188937881148 2.507020729109805 3.151065065533248 0.827344309517849 0.2971633472740571 0.060965312404023 0.2588687133858448 0.1194965359594502 0.0629955787418294 0.180606968360344 +Secondary alcohol metabolic process 18 38 2.2081971386589734 0.0272305337821014 12.097087378640778 42.24514563106796 1.5200936296432006 0.2566232504859334 4.463475425703621 3.883072640851752 1.3223501002339118 0.3210874999447533 4.390206569956567e-06 0.0007819065695012 1.904716605580616e-05 1.8601903634898852e-08 3.991790754377609e-09 +Regulation of hormone levels 26 55 2.1917571964189286 0.0283970433282849 15.682038834951456 62.25485436893204 0.7754141622249116 0.4638741971732045 6.630568201753413 6.49574922456989 1.111399769110166 0.3798141702267368 0.0386806796227716 0.0859112734800016 0.0578004734830958 0.0384014534154076 0.0008283090715149 +Protein import into mitochondrial matrix 6 9 2.1899426764419387 0.0285283944009935 3.3276699029126213 9.03883495145631 1.4677455160780188 0.1396272549365287 1.9612536628062327 0.7162785445212654 1.2893924319512868 0.2212161399323651 0.0194159282105525 0.0022827689145391 0.0088504827764808 0.0498779046475234 0.0005240184523993 +Protein processing 13 38 2.1845686402720195 0.0289204893640271 12.08252427184466 45.980582524271846 0.9011703887478908 0.3916089016010577 4.43430858840224 4.931040148104543 1.176660792763282 0.3507158233798557 0.0009254622688972 0.004358479786631 0.0003706313859541 0.0001369671736733 0.0029570945788725 +Regulation of steroid metabolic process 6 15 2.1675232496998205 0.0301949788644573 4.334951456310679 14.769417475728156 0.4748357054552781 0.3599056508632772 2.2294240946396933 1.955260926764874 1.2378399088740557 0.2930403635554361 0.0395003291534773 1.0 0.3955810682553247 0.0367529115341812 0.0032886276458885 +Regulation of glycoprotein metabolic process 1 6 2.1671629044819976 0.030222434821832 3.592233009708738 10.70631067961165 0.6804974065630551 0.4353046559123504 2.03935499608955 1.985055569049905 0.9883671343018048 0.3255557758909779 0.0618715167696397 0.1263420182810564 0.2372212797486779 0.1467432355955838 0.3963220277929702 +Protein maturation 15 59 2.165412499608092 0.0303561096655147 16.635922330097088 69.29611650485437 0.7279397561088901 0.5092233260742579 5.6828366082703345 6.923625268615643 1.0037762420957868 0.3621314209884535 0.0026040475112899 0.015556573880322 0.0031748281156187 0.0012042600504956 0.0040400525743441 +Protein transmembrane transport 3 23 2.1638142040549697 0.0304786115752202 8.992718446601941 25.191747572815533 1.6893060623430327 0.189108476986505 4.473486660459625 2.7693940759543416 1.4682653164365471 0.2783169275392022 0.0071940498415188 0.0266825716175236 0.0016384890204764 0.0390247080582918 0.0037131193455902 +Vitamin transmembrane transport 2 5 2.161847162855021 0.03062995880341 2.9344660194174756 6.094660194174757 1.6910321805591797 0.1136175735100163 1.344920850275403 0.8913122381585616 1.0580472895861666 0.1862049292817703 0.0194159282105525 1.0 0.0088504827764808 0.0051503840765812 0.033288888151673 +Vitamin transport 2 5 2.161847162855021 0.03062995880341 3.587378640776699 7.597087378640777 1.658661901456128 0.1256251915839625 1.8073839707699664 1.6422194495621811 1.0713624000848283 0.1994200282768667 0.0468940093202156 1.0 0.0219975904219434 0.0195244436529747 0.1078274882909933 +Associative learning 2 9 2.158678564535591 0.030875112895391 3.2985436893203883 11.640776699029129 0.5833637693792252 0.3608696253992166 1.7586672512213413 1.9907766398439397 1.1416749351319833 0.2853176800833586 0.0162384338019031 0.0007225305704933 0.0052800410185589 0.0118572988629309 0.1023001003732698 +Phospholipid transport 5 12 2.149999705969238 0.0315552380400461 4.038834951456311 13.844660194174756 0.8595089147672731 0.22382450694892 1.931709490395295 2.5542930986961077 1.4491821424024287 0.2459407475876757 0.0376094771987919 0.0248381956323572 0.0128487417044244 0.0075944976014186 0.0109403402937121 +Nucleotide transport 8 10 2.149540264135648 0.0315915979041709 6.189320388349515 13.405339805825244 1.3859091987706234 0.2148450774807873 3.399469193898354 2.266957807297256 1.34942986946681 0.2785977875693559 0.0541972194107464 1.0 0.2223047329091382 0.1300982938321277 0.0073870683046854 +Pattern recognition receptor signaling pathway 7 25 2.149289839876725 0.0316114314083741 6.783980582524272 30.48543689320388 0.3893983283533752 0.5277852242642479 3.0860531364168065 4.421623999132768 0.9404779897396882 0.3335139395352661 0.019636390381287 0.4043878907472013 0.0195066935662917 0.0150894096676388 0.1470953110877506 +Regulation of blood pressure 5 14 2.148981275194832 0.0316358842963491 5.762135922330097 17.737864077669904 1.3077123393993415 0.1882731913471478 2.2751770017499977 2.3871059987956724 1.372929386780725 0.2480453688154592 0.0098597877473565 0.0315268496209905 0.0022887430854204 0.0129296559640097 0.0065046833684032 +Glycolipid catabolic process 5 7 2.1439295523756616 0.0320385318722178 3.6310679611650487 6.451456310679611 0.1059933679561382 0.1697430158083476 1.434595381284437 0.7664524352299261 1.9023109688101565 0.2365791262889882 1.9275357824133423e-05 0.0014481500629001 3.74476751148508e-06 1.5560435214860637e-07 9.033677057044543e-06 +Positive regulation of synaptic transmission 5 15 2.1422633130731104 0.0321722992566513 4.813106796116505 17.475728155339805 0.4358203865992658 0.5836764637458288 2.251541663478826 2.30909834121491 0.7613404062503117 0.3040027846338212 0.0034176565559238 0.0444222413024675 0.1454623761357323 0.0068401475593005 0.1225859328480348 +Regulation of phagocytosis 1 12 2.142157656803003 0.0321807975627264 3.3179611650485437 14.968446601941748 0.3209190136413688 0.5915166201342027 2.2957046675959747 2.326811751466005 0.7840787087563237 0.2941325518261171 0.1287125856875722 1.0 0.0640285846884502 0.2797556636969028 0.6236451614269334 +Chloride transport 7 13 2.138875010570082 0.0324457923943792 4.33252427184466 12.12621359223301 1.0302584084066435 0.2341882174183942 2.3624510960969567 2.26059366569241 1.2797232968088257 0.2563105728143979 0.0012572623322763 0.0108643857486399 0.0038117145357013 0.007920049564759 0.0008544422426654 +Ceramide catabolic process 5 7 2.1337560353785583 0.0328627564713353 3.8592233009708736 6.531553398058253 0.1286784152295923 0.1423502941444668 1.429436503356119 0.7012295128365029 2.0219843992394857 0.2259194528389771 1.9275357824133423e-05 0.0014481500629001 0.0001778916397324 1.5560435214860637e-07 9.033677057044543e-06 +Regulation of toll like receptor signaling pathway 3 7 2.131885971063447 0.033016221781789 2.587378640776699 9.50485436893204 0.9772136844316576 0.3297728067967737 1.666236944633112 1.8466647258935645 0.9012634534298872 0.2761306672489575 0.1238525752506518 1.0 0.0614247268920475 0.0808776862517318 0.1443540625367929 +Toll like receptor signaling pathway 4 11 2.130591028099159 0.0331228493459516 3.6529126213592233 14.475728155339803 0.4591583663944621 0.4629288770135975 2.064121680704246 2.5201890058346033 0.9793418922124256 0.3026110620517385 0.084014791731071 1.0 0.0307515849952898 0.0931141624023252 0.260188107677802 +Neuron projection guidance 6 18 2.130091637843971 0.0331640485711888 5.662621359223301 23.189320388349515 0.4437647002001748 0.5678522712486597 2.931294310088859 4.519975354803488 0.8912373776728286 0.311775964869191 0.3082177455267718 0.1354750356227081 0.3700525131557232 0.1068426745449518 0.3236730473499742 +Positive regulation of leukocyte migration 3 12 2.126754475994425 0.0334404886017924 4.097087378640777 15.49757281553398 0.0425334182634543 0.6319024426123137 2.2673904555241178 2.3008006061290747 0.8386767808878971 0.3052449059936994 0.1385628153692513 0.0196403757049561 0.0693457394610891 0.0949405615621671 0.1723337140806459 +Positive regulation of mononuclear cell migration 2 8 2.124885562897374 0.0335961629153538 2.8762135922330097 9.45873786407767 0.0886382248774921 0.5417098390792167 1.6300328286079158 1.7054300369397768 0.9929662660604948 0.3187573347288022 0.0541972194107464 0.0068317681715133 0.0255840399150975 0.0242110622206542 0.1292339698967795 +Detection of biotic stimulus 3 5 2.121088367465934 0.0339143666829044 1.4199029126213591 4.512135922330097 1.0591375818870654 0.2422781473049772 1.0196572764649048 1.0250968701423322 1.0664360760371396 0.2315508201016763 0.0125560894119173 1.0 0.1094892401774078 0.000142755965642 0.0019736987849612 +Carboxylic acid transport 14 26 2.109451136047755 0.0349056595653154 12.351941747572816 33.69417475728155 1.517249458545343 0.2522623764771551 6.23371050940395 4.11174791553619 1.419876490432768 0.3135855212793009 0.1956952760376146 0.3985608327989486 0.2676422850845579 0.2500222799402171 0.0001523227167384 +Establishment of protein localization to membrane 19 77 2.099465475548392 0.0357758881386636 23.133495145631063 87.3616504854369 1.231448880072231 0.4195243824117992 8.397245527204214 9.510228790351464 1.3947369206386535 0.4065372973031916 0.029067126577692 0.6294205244747506 0.0465553733545724 0.0040246499403502 0.0021059207093838 +Ensheathment of neurons 4 20 2.0836163999627044 0.0371950740348487 7.109223300970874 25.317961165048544 0.4295341143396002 0.5630321678871352 3.545161118750975 3.535996271146197 0.857834731365342 0.3150461050621543 0.0389358143917952 1.0 0.5741114914523541 0.0621642703962852 0.2536407090798045 +Protein hydroxylation 4 13 2.076264071382605 0.0378695343262078 5.04126213592233 14.87621359223301 0.7765678108992397 0.4273021352291809 2.482119818897232 1.8660787070180411 0.9906439819977368 0.3285418073460514 0.2962445638593877 0.1093006244161378 0.2070995190727305 0.0195244436529747 0.0051689545539866 +Diol biosynthetic process 4 8 2.0738784238485337 0.0380906033459313 2.5315533980582523 7.747572815533981 0.934609081792458 0.2730932800244148 1.324333323602112 0.9054146354978068 1.183401939154622 0.2688651038177358 0.1732039024356703 1.0 1.0 0.003355333516566 0.0002434795729679 +Diol metabolic process 4 8 2.0738784238485337 0.0380906033459313 2.5315533980582523 7.747572815533981 0.934609081792458 0.2730932800244148 1.324333323602112 0.9054146354978068 1.183401939154622 0.2688651038177358 0.2087359584531155 1.0 1.0 0.0062267265321947 0.000732082482726 +Ion homeostasis 34 90 2.070010851939076 0.0384513282336778 28.021844660194176 105.69174757281552 0.8349951537384392 0.4299135801564597 10.40966729997928 11.411952082971936 1.4722934854811005 0.3963893325418664 0.0089428560166922 0.0745157705462292 0.2146477732815008 0.0011838803888839 0.0015047579915951 +Nervous system process 22 79 2.058419845393698 0.0395498483210192 23.060679611650485 100.46844660194176 0.466210961761844 0.5050785047376438 7.1617042179301365 12.55034423055404 1.1784062094355452 0.368401069133876 0.0161133663747712 0.1332960448317844 0.0433288958317329 0.0409944158658339 0.1940508502980829 +Inorganic anion transmembrane transport 7 8 2.0498742711948226 0.0403767015170555 3.4101941747572817 8.983009708737864 1.1245392058053427 0.2357455210082705 2.3748669786284156 1.7214248641786654 1.1968417731555627 0.2697184972505711 0.0658392940592545 0.1305522111527444 0.031373049189738 0.1552222190730896 0.0022975467393054 +Sphingoid metabolic process 4 5 2.044300139752365 0.0409239054499734 2.337378640776699 5.174757281553398 0.8258730035764346 0.2192038420096116 1.196784089801513 0.5941001920342514 1.4738240163378542 0.2563928956394505 0.0087251906988029 1.0 1.0 0.001485709034831 5.383729574080712e-05 +Cellular hormone metabolic process 8 16 2.037320931970997 0.041617891555872 5.441747572815534 17.32766990291262 0.9908884218524354 0.2940959275691314 2.8170777488519256 1.7185203072340225 1.2515909253444888 0.3031653223897966 0.0062777451714846 0.0248381956323572 0.08610744549237 0.0345596402774107 0.0356847106798374 +Mononuclear cell migration 5 19 2.0316526380019795 0.0421888338107951 6.058252427184466 23.645631067961165 0.0105016163762546 0.6303901682999394 3.102067092594892 2.7844323365283423 0.8660601863335294 0.3059427019687199 0.0707957395799711 0.0399341953324298 0.1323300889211223 0.0216033331890521 0.0397726884021936 +Regulation of lipase activity 1 10 2.0284656826358543 0.042512742347023 3.262135922330097 11.20873786407767 0.5080857493577803 0.3640362286084045 2.107366483573331 1.390020380944142 1.1722840995258883 0.3007278087276755 0.4434536435935927 0.1755724648168266 0.0563311776114605 0.2526409373615763 0.3060121360259066 +Membrane lipid biosynthetic process 9 17 2.0137594386894557 0.0440347961614344 8.866504854368932 23.050970873786408 1.3229385051208649 0.2431293012321725 4.229937732502716 3.4850337476777224 1.635527795490498 0.2996124846932806 0.1164063979250678 1.0 0.5484830827387088 0.0485304500002844 0.0060577711992828 +Antigen processing and presentation of peptide antigen via mhc class i 4 8 2.013491695187139 0.044062927779332 3.5533980582524274 10.33980582524272 0.9522781165124746 0.321717188118692 1.7458864571217907 1.7766194475253527 0.972074824811495 0.2764762653101907 0.039990310390257 1.0 0.018640880521655 0.0017432511761074 0.0034687949642114 +Cognition 6 28 2.002484681969555 0.0452326289485425 8.381067961165048 35.51456310679612 0.106014143429431 0.585314562092836 3.4293041589801794 4.867395144092575 0.9639094447868622 0.3250247192097197 0.1709630989892687 0.0345549875109359 0.0551812689419767 0.0701727880371963 0.4348747538764422 +Circulatory system process 18 57 2.0020998142499384 0.0452739975110374 17.152912621359224 72.00970873786407 0.7968086684699157 0.4206667688960129 5.8797345113877215 8.195718922280731 1.282615010632819 0.3676426088525382 0.002741531925214 0.3247861662592866 0.0289369860172545 0.0147760546444614 0.0002812264905817 +Macromolecule depalmitoylation 2 5 1.9978198128050788 0.0457361985452053 1.91747572815534 5.429611650485437 0.9780254626091984 0.222941388490727 1.137611804765983 0.8139540579221628 1.3123017012345466 0.2566673774233151 0.0125560894119173 0.0014481500629001 0.0056684159955205 0.00262770885776 0.0019736987849612 +Protein insertion into er membrane 5 11 1.977896882939021 0.0479403406778933 4.451456310679611 12.691747572815531 0.9645901040516046 0.3077872373135509 2.16101217194965 1.431147904526304 1.1733171268605926 0.305304417896891 0.2753130198213776 1.0 0.191600110602388 0.4172977923286156 0.0004815297744428 +Ceramide transport 4 6 1.976700573377319 0.0480754859679748 1.779126213592233 5.310679611650485 0.994079753441996 0.2057455404068654 1.027416031856974 0.785538294365343 1.3065287972688011 0.2361222749942 0.1732039024356703 0.0607401038440192 0.1180585699575878 0.0382400085743442 0.0002434795729679 +Vascular process in circulatory system 8 22 1.972355569447421 0.0485690301177139 8.218446601941748 31.361650485436893 0.5302527350177477 0.4259259059419516 3.6564678051714665 4.365329555745678 1.181021277396986 0.3310828049268227 0.022619304253189 0.0993430224952972 0.091109134162985 0.131977495406029 0.0184855075941836 +Regulation of cell killing 5 8 1.9711147210152555 0.0487107552842482 2.844660194174758 8.366504854368932 0.4041102541319114 0.4507662844932221 1.5842506516490529 1.3031494402288128 1.0522249449787806 0.3118972087461248 0.3555035308690595 1.0 1.0 0.0352396407582777 0.0027564644815256 +Regulation of leukocyte migration 7 20 1.9665036547889607 0.0492404605666914 6.080097087378641 26.6504854368932 0.4712165673240142 0.5560717407414059 2.980664549328318 3.842679935245632 0.8934424673809059 0.3310773445531978 0.0895780228267424 0.0479057539651017 0.1554832015057707 0.1005919349614823 0.0243632047080926 +Response to manganese ion 3 5 1.964654049406126 0.0494542916840765 1.6237864077669903 4.803398058252427 0.1657661936697436 0.3714959689201358 1.1370705133968653 0.8633239594876049 1.253188844081787 0.2928478007224994 0.0007703502012677 0.0607401038440192 0.1180585699575878 0.003355333516566 0.0027426851014433 +Regulation of leukocyte mediated cytotoxicity 5 7 1.963558865422616 0.0495812716533485 2.5825242718446604 7.334951456310679 0.4511695306521209 0.4227043221453989 1.4499700153890709 1.2995300672557608 1.082342679990832 0.3098039206468536 0.2962445638593877 1.0 1.0 0.0195244436529747 0.0007997701188881 diff --git a/msigdb_gobp/metrics.json b/msigdb_gobp/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..3caf44cb432ab4757ba6b1316f0458efb2b6e9df --- /dev/null +++ b/msigdb_gobp/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2644, + "annotations_size": 6226, + "title": "Average number of proteins per term", + "value": 16.8270157404433 +} \ No newline at end of file diff --git a/msigdb_gobp/paths.json b/msigdb_gobp/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..ca09927fcc21acba0d52b1f69b9c05e01b1004b2 --- /dev/null +++ b/msigdb_gobp/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/msigdb_gobp/fragment/C197/C197_val_log2fc"} \ No newline at end of file diff --git a/msigdb_gobp/result.tsv b/msigdb_gobp/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..9845f1e8bd09313680aad7af1bda6cd7f1c37cba --- /dev/null +++ b/msigdb_gobp/result.tsv @@ -0,0 +1,1648 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Lytic vacuole organization 0.8151585114533965 3.182138726694294 0.0014619177599637 0.999889285924842 0.7815937456234014 20 P10253,O75503,O75787,Q8N511,P50897,P11117,P07686,P54802,Q14108,O14773 10 +Anion transport 0.6597155432602647 3.1520629917480427 0.0016212129490522 0.9999589968912296 0.7815937456234014 60 P12235,Q8TB61,P30536,P07602,P53985,P21796,Q9UBX3,Q9C0H2,P08195,Q9Y619,P08183,P14174,P51798,P55011,P45880,Q15041,P51790,Q99808,Q00325,Q9H2D1,Q9UHG3,O60831,O43681,Q15758,Q9UHQ9,Q96NB2,Q9Y277,Q9Y5P4,P12236,Q96S66,Q9Y6M7,Q96QD8,O95563,Q9NZJ7,Q9H0H5 35 +Membrane lipid metabolic process 0.7667900030580297 3.0437754896508777 0.0023362942238647 0.9999995263446768 0.7815937456234014 32 Q13510,P50897,P06280,P07602,Q96G23,P06865,P16278,O15269,Q99735,Q16739,O95470,P04062,Q8NCC3,Q9H2C2,P04066,P17900,Q8NBX0,Q9Y5P4,Q06136,P07686,Q9NZJ7 21 +Sphingolipid metabolic process 0.7687397179515214 2.9892792217479824 0.0027963645665602 0.999999973191688 0.7815937456234014 27 Q13510,P04062,P16278,Q9Y5P4,P50897,O15269,P06280,Q8NCC3,P07602,Q06136,Q9H2C2,Q16739,P07686,Q9NZJ7,Q96G23,O95470,P17900,P06865 18 +Aminoglycan metabolic process 0.8313037737287404 2.986490805635647 0.0028219932404893 0.9999999771557748 0.7815937456234014 14 P16278,P08236,P15586,P07686,P04066,P54802,Q01459,P06865,O43505 9 +Regulation of cellular ph 0.7859299029304398 2.9472973216179494 0.003205648179269 0.9999999979190136 0.7815937456234014 17 O75503,Q9Y487,O75787,Q8N511,P50897,P51790,Q9Y6M7,Q93050,Q15904 9 +Regulation of ph 0.7859299029304398 2.9472973216179494 0.003205648179269 0.9999999979190136 0.7815937456234014 17 O75503,Q9Y487,O75787,Q8N511,P50897,P51790,Q9Y6M7,Q93050,Q15904 9 +Cellular monovalent inorganic cation homeostasis 0.758764510790007 2.883156176865245 0.003937121874133 0.9999999999784556 0.7815937456234014 21 P05026,O75503,Q9Y487,O75787,Q8N511,P50897,P51790,Q9Y6M7,Q93050,Q15904 10 +Ph reduction 0.8456761863918264 2.8785366199077274 0.0039952489301138 0.9999999999850192 0.7815937456234014 11 Q9Y487,O75503,Q8N511,P50897,P51790,Q93050 6 +Ceramide metabolic process 0.7698484864614779 2.861777480607723 0.0042127256085915 0.9999999999961534 0.7815937456234014 17 Q13510,P04062,Q9Y5P4,Q8NCC3,O15269,P06280,P07686,Q16739,Q96G23,P17900,P06865 11 +Steroid metabolic process 0.6102100534036536 2.80944223800408 0.00496274236838 0.9999999999999648 0.7815937456234014 61 Q13510,P30536,Q9BQE5,Q8NBQ5,P05067,Q16850,Q99538,O14975,P61916,O75845,O75477,Q14739,Q9UKR5,Q6P1A2,P48449,Q9UBM7,O95470,P04062,Q8WTV0,Q15392,Q9H2C2,Q53GQ0,P38571,Q14534,O15118 25 +Monovalent inorganic cation homeostasis 0.7346375155527627 2.767206309020408 0.0056538962624499 0.9999999999999996 0.7815937456234014 24 P05026,O75503,Q9Y487,O75787,Q8N511,P50897,P51790,Q9Y6M7,Q93050,P04899,Q15904 11 +Lipid localization 0.592816729059403 2.761976897492127 0.0057452543563873 0.9999999999999998 0.7815937456234014 63 P30536,Q9BQE5,P07602,O15260,Q9H2V7,P08183,Q14108,Q9H6V9,P35790,O14975,P61916,Q16739,Q6P1A2,Q9Y3D6,Q96GC9,P04062,Q8WTV0,Q9H4M9,Q9H2C2,O43772,P17900,P23786,Q9Y5P4,Q14534,Q99720,P07686,Q9BUR5,O15118,Q9NZJ7 29 +Liposaccharide metabolic process 0.8097000436825847 2.7598252349873964 0.005783228999725 0.9999999999999998 0.7815937456234014 12 P16278,P06280,P07686,Q16739,P04066,P17900,P06865 7 +Locomotory behavior 0.731675366892151 2.7502318231958984 0.0059553116163608 1.0 0.7815937456234014 24 P10253,P50897,P51790,P05067,P07686,O75844,P54802 7 +Anion transmembrane transport 0.7029752800988689 2.7383482630270626 0.0061748647745898 1.0 0.7815937456234014 37 P12235,Q8TB61,P53985,P21796,Q9UBX3,P08195,Q9Y619,P08183,P45880,P51798,P55011,Q15041,P51790,Q00325,Q9H2D1,Q9UHG3,O60831,Q15758,Q96NB2,Q9Y277,Q9Y6M7,O95563 22 +Inorganic anion transport 0.7262163440243243 2.7121180286128768 0.0066854783227794 1.0 0.7815937456234014 23 Q9H0H5,Q9UHG3,P45880,P30536,P51798,P55011,O43681,P51790,Q96S66,P21796,Q9UBX3,Q00325,Q9C0H2,Q9Y6M7,P08183,Q9Y277 16 +Membrane lipid catabolic process 0.7975482537940162 2.699341298027398 0.0069476884010732 1.0 0.7815937456234014 12 Q13510,P04062,P50897,P06280,Q99735,P07686,P04066,P17900,P06865 9 +Regulation of pattern recognition receptor signaling pathway 0.7505338091853446 2.6324128202492316 0.0084780778201385 1.0 0.7815937456234014 15 O75955,Q06481,O43657,Q07021,Q9NUD5,Q9NPR9 6 +Antigen processing and presentation 0.7268332610117825 2.62835382552563 0.0085799221138591 1.0 0.7815937456234014 17 P04062,P01889,Q9UIQ6,P04439,Q99538,P10321 6 +Adult locomotory behavior 0.7696606543699949 2.6148319948786916 0.0089271354654014 1.0 0.7815937456234014 13 P50897,O75844,P51790,P05067 4 +Vacuole organization 0.6637178426646211 2.602706850534712 0.0092491001554155 1.0 0.7815937456234014 43 P10253,O75503,O75787,Q8N511,P50897,P11117,P07686,P54802,Q14108,O14773,Q96GC9 11 +Adult behavior 0.719922928665486 2.5902026087634376 0.0095919459193005 1.0 0.7815937456234014 17 P50897,P51790,P05067,O75844,O15118 5 +Vacuolar acidification 0.8530822477309652 2.547710659565315 0.0108432363553279 1.0 0.7815937456234014 9 Q9Y487,O75503,Q8N511,P50897,Q93050 5 +Endocytosis 0.5210708778190931 2.5441610563300148 0.0109540564303427 1.0 0.7815937456234014 91 P50897,P05067,O15260,Q9NR12,Q14108,Q08380,Q06787,P11717,Q5VW38,O00429,P51790,P20645,Q9H223,Q06481,Q8WTV0,O00560,Q5KU26,Q99523,O75955,P02786,Q9NX40,P51809,O15118 23 +Carbohydrate derivative transport 0.7445096514606494 2.5414037576720827 0.0110408338049436 1.0 0.7815937456234014 14 P12235,Q8TB61,Q9HC21,P12236,Q8WTV0,P61916,P05141,P07602,Q99808,Q6NUK1,L0R6Q1,Q9NZJ7 12 +Oligosaccharide metabolic process 0.9275582400110244 2.533665584044339 0.0112876396778736 1.0 0.7815937456234014 7 P10253,O00462,P06280,P07686,P17900 5 +Behavior 0.5671206641034997 2.4989241380355818 0.0124570974749684 1.0 0.7815937456234014 62 P04062,P10253,P30536,P50897,P51790,P05067,O00264,Q99538,P07686,O75844,P54802,O15118,Q92542,P17900 14 +Neuromuscular process controlling balance 0.7565707432013772 2.491917074046652 0.0127055697825053 1.0 0.7815937456234014 12 P10253,O14773,P17900,P05067 4 +Hormone metabolic process 0.6800346470122025 2.47705331373954 0.0132472112367629 1.0 0.7815937456234014 28 Q53GQ0,P49189,P07858,Q9HB40,O75787,P30536,Q8NBQ5,O75844,P42892,Q8TAD4,Q9UBM7,O95470 12 +Organic acid transmembrane transport 0.6846975134237085 2.4761335542101492 0.0132813886011351 1.0 0.7815937456234014 24 P23786,Q9H2D1,O60831,O95563,Q15041,P53985,Q15758,Q9UBX3,Q96QD8,P08195,O43772,Q9Y619,P08183 13 +Glycosaminoglycan catabolic process 0.960970064418341 2.472175354585304 0.0134293625769519 1.0 0.7815937456234014 5 P15586,P54802,P04066,P16278 4 +Glycoside metabolic process 0.835256074959227 2.467259277207715 0.0136151732340796 1.0 0.7815937456234014 9 P08236,P06280,P04066,Q9BTY2,Q9NUJ1 5 +Lipoprotein metabolic process 0.7492133331974857 2.4540973941753177 0.0141238722311591 1.0 0.7815937456234014 12 Q16739,P50897,Q9BQE5,Q9NUJ1 4 +Aminoglycan catabolic process 0.9446550416982524 2.4519057726345723 0.014210186786681 1.0 0.7815937456234014 6 P16278,P08236,P15586,P54802,P04066 5 +Antigen processing and presentation of peptide antigen 0.7960307789279453 2.4515064121846804 0.0142259651831315 1.0 0.7815937456234014 10 P01889,Q9UIQ6,P04439,Q99538,P10321 5 +Intracellular lipid transport 0.7557079885383136 2.43413696987089 0.0149273452613776 1.0 0.7815937456234014 11 P23786,P61916,Q9H2C2,O15118,O43772 5 +Carbohydrate derivative catabolic process 0.6682825223407558 2.433943520756527 0.0149353253315116 1.0 0.7815937456234014 31 Q9H773,P16278,O00462,P08236,P06280,P15586,P07686,P54802,P04066,Q01459,Q9BTY2,Q9NUJ1,P17900,P06865 14 +Long term synaptic potentiation 0.8219869319722849 2.406849693119099 0.0160907908485967 1.0 0.7815937456234014 9 Q99538,Q92542,P05067 3 +Regulation of carbohydrate catabolic process 0.7395276389084363 2.404036957327373 0.0162151339025331 1.0 0.7815937456234014 12 P05067 1 +Regulation of long term synaptic potentiation 0.9300474050007 2.3941943325331314 0.016656920788352 1.0 0.7815937456234014 6 Q99538,Q92542,P05067 3 +Regulation of multicellular organism growth 0.7372761657032055 2.3923556333166913 0.0167406125373541 1.0 0.7815937456234014 12 Q99538,O75844,Q9HCL2,P05067 4 +Learning 0.7058873058283254 2.391833058842607 0.0167644657408936 1.0 0.7815937456234014 15 P50897,P05067 2 +Glycoside catabolic process 0.9283548142532154 2.3874812424062704 0.0169642684297943 1.0 0.7815937456234014 6 P08236,P06280,P04066,Q9BTY2,Q9NUJ1 5 +Cellular ion homeostasis 0.485730717138508 2.3780400683603413 0.0174049345403806 1.0 0.7815937456234014 76 O75503,O43819,P50897,P05067,Q9UJZ1,Q92544,O76024,O75787,P55011,P51790,P61421,P16615,Q93050,Q9Y3D6,P35670,P05026,P62942,P09601,Q8TAD4,Q96A33,Q9Y487,P02786,P05023,Q8N511,Q9HD20,P07686,Q9Y6M7,P51149,Q15904 29 +Amino acid transport 0.692590503812338 2.3769762051248335 0.017455214094725 1.0 0.7815937456234014 16 Q6P4A7,O60831,P55011,Q15041,Q15758,Q96QD8,P08195,Q9Y619,Q96H78 9 +Alcohol metabolic process 0.4826174161419779 2.3727733350900557 0.0176550946347266 1.0 0.7815937456234014 74 Q13510,O15270,Q9BQE5,P05067,Q16850,O75874,Q10713,P61916,O15269,O75845,O75477,Q14739,Q6P1A2,P48449,Q9UBM7,P04062,Q8WTV0,P35270,Q15392,Q9H2C2,P51648,Q14534,O15118,P16435,P48735 25 +Glycosphingolipid metabolic process 0.8507557942723414 2.368219333117006 0.0178739361698141 1.0 0.7815937456234014 8 P16278,P06280,P07686,Q16739,P17900,P06865 6 +Regulation of mononuclear cell migration 0.7222314819389077 2.367414771362738 0.0179128452520433 1.0 0.7815937456234014 13 Q07021,Q99538,O94813,P05067 4 +Mitochondrial respiratory chain complex assembly 0.6608439607546653 2.3592199060048022 0.0183133998642126 1.0 0.7815937456234014 28 O96000,O95831,Q96CU9,O43819,O43674,Q9H061,O75306,O43676,Q69YU5,Q9BRT2,Q6DKK2 11 +Cellular carbohydrate catabolic process 0.6892878707341955 2.358524919955743 0.0183477278516221 1.0 0.7815937456234014 16 Q14108,P10253,Q9NUJ1 3 +Neuromuscular process 0.6669773429168789 2.3583199313169803 0.018357863766484 1.0 0.7815937456234014 21 P10253,P05067,P07686,O75844,O14773,P17900 6 +Regulation of steroid biosynthetic process 0.7743496472546589 2.3469533448290023 0.0189276246698986 1.0 0.7815937456234014 10 Q13510,P30536,O75477,Q6P1A2,P16435,Q9UBM7 6 +Entry into host 0.6574572539825426 2.3466155519851695 0.0189447908790052 1.0 0.7815937456234014 29 P11279,Q8WTV0,P07858,P02786,P35613,O15118,P08195,Q9BTY2,Q14108 9 +Organic anion transport 0.6364125275568223 2.338369066654804 0.0193681109747643 1.0 0.7815937456234014 39 Q9HC21,Q8TB61,P12235,P05141,P07602,P53985,Q86VD7,Q9UBX3,P08195,Q9Y619,P14174,P55011,Q15041,Q99808,Q9H2D1,O60831,Q02978,Q15758,Q9UHQ9,Q96NB2,P28288,O75915,Q9Y5P4,P12236,Q9Y6M7,Q6NUK1,Q96QD8,O95563,Q9NZJ7 29 +Regulation of nervous system process 0.7711515587472606 2.331416994293026 0.0197313822812927 1.0 0.7815937456234014 10 Q06787,P53634,Q9UQB8,P05067 4 +Amino acid transmembrane transport 0.7199896525135472 2.302103531674525 0.0213293343126488 1.0 0.7815937456234014 12 O60831,Q15041,Q15758,Q96QD8,P08195,Q9Y619 6 +Membrane protein proteolysis 0.7286857214117461 2.2957019620746735 0.0216929281936983 1.0 0.7815937456234014 11 Q92542,Q16740,Q8TCT8,O43847,Q9NZ08 5 +Organophosphate ester transport 0.6548796801307777 2.289346345668245 0.022059236917802 1.0 0.7815937456234014 22 P12235,Q8TB61,Q9H2D1,Q8WTV0,P22059,Q9Y5P4,P61916,Q99808,P08183,Q14108,Q96GC9 11 +Regulation of receptor mediated endocytosis 0.6553589193118927 2.28585338029016 0.0222628375858267 1.0 0.7815937456234014 19 Q06787,O00560,P50897,P05067 4 +Nadh dehydrogenase complex assembly 0.6539668515455804 2.2776475131299456 0.022747587241233 1.0 0.7815937456234014 19 Q96CU9,O75306,O43676,Q9H061 4 +Organic acid transport 0.6314164236228665 2.2727030532505945 0.0230440805436984 1.0 0.7815937456234014 37 P53985,Q9UBX3,P08195,Q9Y619,P08183,P14174,O14975,P55011,Q15041,Q9Y3D6,Q9H2D1,Q6P4A7,O60831,Q15758,O43772,Q96H78,P23786,Q96QD8,O95563 19 +Dicarboxylic acid transport 0.7223958463652961 2.263139593385849 0.0236270855211551 1.0 0.7815937456234014 11 Q9H2D1,O60831,P55011,Q02978,Q15758,Q15041,Q9UBX3 7 +Reactive nitrogen species metabolic process 0.6924656248829478 2.262070663155023 0.0236930378046564 1.0 0.7815937456234014 14 P30536,P06280,P35270,O43169,Q92945,Q5VT66 6 +Protein transmembrane import into intracellular organelle 0.7119149080912346 2.2596014011711607 0.0238460005661309 1.0 0.7815937456234014 12 Q15388,Q99595,O96008,O95831,O43615,O60830,O14925,Q3ZCQ8 8 +Connective tissue development 0.6498035669863934 2.2530565528562434 0.0242555834252735 1.0 0.7815937456234014 19 Q92896,P43490,O75844 3 +Oligosaccharide catabolic process 0.943939393939395 2.249407986195908 0.0244865509723357 1.0 0.7815937456234014 4 O00462,P07686,P17900 3 +L amino acid transport 0.717189688588261 2.2360899665446676 0.0253458785546043 1.0 0.7815937456234014 11 O60831,Q15041,Q96QD8,P08195,Q9Y619 5 +Positive regulation of long term synaptic potentiation 0.9400331085013112 2.2339674041472297 0.0254852178734339 1.0 0.7815937456234014 4 Q99538,P05067 2 +Lysosomal lumen acidification 0.937500000000002 2.223941758423571 0.0261523630412718 1.0 0.7815937456234014 4 Q8N511,P50897,O75503 3 +Regulation of lysosomal lumen ph 0.937500000000002 2.223941758423571 0.0261523630412718 1.0 0.7815937456234014 4 Q8N511,P50897,O75503 3 +Leukocyte mediated cytotoxicity 0.6840879724134884 2.2161935163499487 0.0266782517368315 1.0 0.7815937456234014 14 P11279,O15400,P46108,P01889,P51809,P04439,P53634 7 +Sterol metabolic process 0.624879792240132 2.2146848980152365 0.0267817001513921 1.0 0.7815937456234014 36 P38571,P04062,Q8WTV0,Q14534,P61916,Q9BQE5,O75845,O75477,P05067,Q16850,Q14739,Q15392,Q9UKR5,Q9H2C2,O15118,Q6P1A2,P48449,Q9UBM7 18 +Positive regulation of endocytosis 0.6830396558713223 2.2104347496649885 0.0270750043407714 1.0 0.7815937456234014 14 P50897,Q06481,Q06787 3 +Secondary alcohol metabolic process 0.6195986846877026 2.2081971386589734 0.0272305337821014 1.0 0.7815937456234014 38 P04062,Q8WTV0,Q14534,P61916,Q9BQE5,O75845,O75477,P05067,Q16850,Q14739,Q15392,O75874,Q9H2C2,O15118,Q6P1A2,P48449,Q9UBM7,P48735 18 +Regulation of hormone levels 0.5629881173640021 2.1917571964189286 0.0283970433282849 1.0 0.7815937456234014 55 Q7Z7E8,Q16836,P07858,Q9HB40,P30536,Q8NBQ5,P53985,Q8TC12,P42892,Q9BRT2,P49189,O75787,O75844,Q9UBM7,O95470,P22059,Q8TAD4,O00186,Q53GQ0,P05023,P00367,P51809,P40939,Q8NBN7,P16435,O95563 26 +Protein import into mitochondrial matrix 0.7751401972083128 2.1899426764419387 0.0285283944009935 1.0 0.7815937456234014 9 Q15388,Q99595,O60830,O43615,O14925,Q3ZCQ8 6 +Protein processing 0.6161266962546278 2.1845686402720195 0.0289204893640271 1.0 0.7815937456234014 38 O75976,Q10713,O75503,O75787,Q92896,Q5JRX3,Q15392,Q99538,P67812,O75844,P42892,Q92542,Q8TAD4 13 +Glial cell proliferation 0.9263575259831472 2.1797217010652497 0.029278096947622 1.0 0.7815937456234014 4 P30536,Q96G23 2 +Regulation of steroid metabolic process 0.6654443393460692 2.1675232496998205 0.0301949788644573 1.0 0.7815937456234014 15 Q13510,P30536,O75477,Q9H2C2,Q6P1A2,Q9UBM7 6 +Regulation of glycoprotein metabolic process 0.8735465398924589 2.1671629044819976 0.030222434821832 1.0 0.7815937456234014 6 Q9NQX7 1 +Protein maturation 0.5425171029470097 2.165412499608092 0.0303561096655147 1.0 0.7815937456234014 59 O75976,Q86UY6,Q10713,O75503,O75787,Q92896,Q5JRX3,Q15392,Q99538,P67812,O75844,Q6P1A2,P42892,Q92542,Q8TAD4 15 +Protein transmembrane transport 0.6336390435262109 2.1638142040549697 0.0304786115752202 1.0 0.7815937456234014 23 Q99595,Q9NS69,O60830 3 +Vitamin transmembrane transport 0.8829673455276985 2.161847162855021 0.03062995880341 1.0 0.7815937456234014 5 Q9H2D1,Q8WTV0 2 +Vitamin transport 0.8829673455276985 2.161847162855021 0.03062995880341 1.0 0.7815937456234014 5 Q9H2D1,Q8WTV0 2 +Associative learning 0.7684878025454936 2.158678564535591 0.030875112895391 1.0 0.7815937456234014 9 P50897,P05067 2 +Antigen processing and presentation of exogenous peptide antigen 0.9202266515071594 2.155307850687425 0.0311377518657871 1.0 0.7815937456234014 4 Q99538,Q9UIQ6 2 +Phospholipid transport 0.6912829430689841 2.149999705969238 0.0315552380400461 1.0 0.7815937456234014 12 Q8WTV0,Q9Y5P4,P61916,Q14108,Q96GC9 5 +Nucleotide transport 0.7341566341215369 2.149540264135648 0.0315915979041709 1.0 0.7815937456234014 10 Q9HC21,P12235,Q8TB61,Q9H2D1,P12236,P05141,Q99808,Q6NUK1 8 +Pattern recognition receptor signaling pathway 0.6300314429099322 2.1492898398767255 0.0316114314083741 1.0 0.7815937456234014 25 O75955,Q06481,O43657,Q07021,Q9NUD5,Q5KU26,Q9NPR9 7 +Regulation of blood pressure 0.671898052696416 2.148981275194832 0.0316358842963491 1.0 0.7815937456234014 14 Q9HB40,O75787,Q9UIQ6,P42785,P42892 5 +Signaling receptor ligand precursor processing 0.9174500279058018 2.1442317930343666 0.0320143188334851 1.0 0.7815937456234014 4 O75787,P42892 2 +Glycolipid catabolic process 0.8342367048141974 2.1439295523756616 0.0320385318722178 1.0 0.7815937456234014 7 P06280,P07686,P04066,P17900,P06865 5 +Positive regulation of synaptic transmission 0.6609588322051316 2.1422633130731104 0.0321722992566513 1.0 0.7815937456234014 15 P05067,Q13501,Q99538,Q92542,Q06787 5 +Regulation of phagocytosis 0.6898170876676082 2.142157656803003 0.0321807975627264 1.0 0.7815937456234014 12 Q06481 1 +Chloride transport 0.679688961636512 2.138875010570082 0.0324457923943792 1.0 0.7815937456234014 13 Q9UHG3,P51798,P55011,P30536,P51790,Q9C0H2,P08183 7 +Ceramide catabolic process 0.8318578373196512 2.1337560353785583 0.0328627564713353 1.0 0.7815937456234014 7 Q13510,P06280,P07686,P17900,P06865 5 +Regulation of toll like receptor signaling pathway 0.8314208634269733 2.131885971063447 0.033016221781789 1.0 0.7815937456234014 7 O75955,Q06481,Q9NPR9 3 +Toll like receptor signaling pathway 0.697045569775153 2.130591028099159 0.0331228493459516 1.0 0.7815937456234014 11 O75955,Q06481,Q9NPR9,Q5KU26 4 +Neuron projection guidance 0.6291417472923345 2.130091637843971 0.0331640485711888 1.0 0.7815937456234014 18 Q15375,O94813,P35613,O00264,P05067,P42892 6 +Regulation of monocyte chemotaxis 0.9135903879733532 2.1288157274270256 0.0332695091949915 1.0 0.7815937456234014 4 Q99538 1 +Positive regulation of leukocyte migration 0.6869418634925222 2.1267544759944252 0.0334404886017924 1.0 0.7815937456234014 12 Q07021,Q99538,P05067 3 +Positive regulation of mononuclear cell migration 0.795829577295836 2.124885562897374 0.0335961629153538 1.0 0.7815937456234014 8 Q99538,P05067 2 +Detection of biotic stimulus 0.8729208973907873 2.121088367465934 0.0339143666829044 1.0 0.7815937456234014 5 P30536,P01889,Q8WTV0 3 +Carboxylic acid transport 0.6228878475758203 2.109451136047755 0.0349056595653154 1.0 0.7815937456234014 26 P14174,Q9H2D1,O60831,P55011,P07602,P53985,Q15041,Q15758,Q9UBX3,Q96QD8,P08195,Q9Y619,O95563,Q9NZJ7 14 +Establishment of protein localization to membrane 0.4602625978145165 2.0994654755483917 0.0357758881386636 1.0 0.7815937456234014 77 O14737,P43307,Q9H8Y8,P27105,Q15041,Q9NPA0,Q8N2H4,Q9Y3D6,P46379,P05026,Q9NS69,O00560,O43681,O60725,Q15629,Q96A33,Q9HD20,O15118,Q15904 19 +Ensheathment of neurons 0.621413264927622 2.0836163999627044 0.0371950740348487 1.0 0.7815937456234014 20 Q92542,P07686,Q9NR77,P53634 4 +Protein hydroxylation 0.6682368382186552 2.076264071382605 0.0378695343262078 1.0 0.7815937456234014 13 Q9NWT6,Q92791,O75718,Q32P28 4 +Diol biosynthetic process 0.7845135301775356 2.0738784238485337 0.0380906033459313 1.0 0.7815937456234014 8 Q13510,P04062,O15269,P35270 4 +Diol metabolic process 0.7845135301775356 2.0738784238485337 0.0380906033459313 1.0 0.7815937456234014 8 Q13510,P04062,O15269,P35270 4 +Ion homeostasis 0.4736228673981756 2.0700108519390756 0.0384513282336778 1.0 0.7815937456234014 90 O75503,O43819,P50897,P30536,P05067,P48506,Q9UJZ1,Q92544,O76024,O75787,P55011,P51790,P61421,P16615,Q93050,Q9Y3D6,P35670,P05026,P62942,P30519,P09601,Q6P4Q7,Q8TAD4,Q96A33,Q9Y487,P02786,Q8N511,P05023,Q9HD20,P07686,Q9Y6M7,P51149,P04899,Q15904 34 +Nervous system process 0.4589215501167026 2.058419845393698 0.0395498483210192 1.0 0.7815937456234014 79 P50897,P05067,Q99538,P07196,Q14108,Q06787,Q99808,O75844,O14773,P04062,Q96P11,Q6P4Q7,P53634,P17900,P10253,Q9UQB8,Q9H6K4,Q15555,O00264,P07686,Q92542,O75569 22 +Inorganic anion transmembrane transport 0.7792109256448883 2.0498742711948226 0.0403767015170555 1.0 0.7815937456234014 8 Q9UHG3,P51798,P55011,P51790,Q00325,Q9UBX3,Q9BXP2 7 +Sphingoid metabolic process 0.8541114058355461 2.044300139752365 0.0409239054499734 1.0 0.7815937456234014 5 Q13510,P04062,O15269,Q06136 4 +Cellular hormone metabolic process 0.6329746219179577 2.0373209319709975 0.041617891555872 1.0 0.7815937456234014 16 Q53GQ0,Q9HB40,P30536,Q8NBQ5,Q8TC12,Q8NBN7,P42892,O95470 8 +Mononuclear cell migration 0.6128744381007596 2.0316526380019795 0.0421888338107951 1.0 0.7815937456234014 19 P04062,O94813,P05067,Q07021,Q99538 5 +Regulation of lipase activity 0.70996782245597 2.0284656826358543 0.042512742347023 1.0 0.7815937456234014 10 P50897 1 +Membrane lipid biosynthetic process 0.6194105241062966 2.0137594386894553 0.0440347961614344 1.0 0.7815937456234014 17 Q13510,P04062,O15270,O15269,Q06136,Q16739,Q96G23,O95470,Q8NBX0 9 +Antigen processing and presentation of peptide antigen via mhc class i 0.7712012335862183 2.013491695187139 0.044062927779332 1.0 0.7815937456234014 8 P04439,Q9UIQ6,P01889,P10321 4 +Keratan sulfate metabolic process 0.9647860658841362 2.009260272016494 0.0445095387519012 1.0 0.7815937456234014 3 P15586,P16278 2 +Cognition 0.6043658532989922 2.002484681969555 0.0452326289485425 1.0 0.7815937456234014 28 P50897,P05067,Q96P11,Q99538,Q92542,P17900 6 +Circulatory system process 0.5317444293651975 2.0020998142499384 0.0452739975110374 1.0 0.7815937456234014 57 P05026,Q14126,P10253,O94813,Q9HB40,O75787,P02786,O00429,Q9UIQ6,P53985,P42785,Q16625,O75844,Q96QD8,P42892,P08183,P04899,Q9NZ08 18 +Macromolecule depalmitoylation 0.8427985108649042 1.9978198128050788 0.0457361985452053 1.0 0.7815937456234014 5 P50897,Q9NUJ1 2 +Phosphatidylethanolamine metabolic process 0.8778313655938798 1.984912612037654 0.047154194947605 1.0 0.7815937456234014 4 Q8NCC3 1 +Ganglioside metabolic process 0.9575918212798172 1.980951807949627 0.0475966782926247 1.0 0.7815937456234014 3 P17900,P06865 2 +Ganglioside catabolic process 0.9575918212798172 1.980951807949627 0.0475966782926247 1.0 0.7815937456234014 3 P17900,P06865 2 +Protein insertion into er membrane 0.6683299532265167 1.977896882939021 0.0479403406778933 1.0 0.7815937456234014 11 O43681,Q9NPA0,Q15629,Q96A33,P46379 5 +Ceramide transport 0.8272687580076296 1.976700573377319 0.0480754859679748 1.0 0.7815937456234014 6 P08183,Q9NZJ7,Q9Y5P4,P07602 4 +Vascular process in circulatory system 0.6030054646001053 1.972355569447421 0.0485690301177139 1.0 0.7815937456234014 22 O94813,Q9HB40,P02786,P53985,Q16625,Q96QD8,P42892,P08183 8 +Regulation of cell killing 0.7619127787184702 1.971114721015255 0.0487107552842482 1.0 0.7815937456234014 8 P11279,O15400,P46108,P01889,P04439 5 +Regulation of leukocyte migration 0.6022624906578666 1.9665036547889607 0.0492404605666914 1.0 0.7815937456234014 20 P14174,P46108,O94813,O00429,P05067,Q07021,Q99538 7 +Membrane protein intracellular domain proteolysis 0.9537161614000764 1.9656771541580724 0.0493359154462247 1.0 0.7815937456234014 3 Q8TCT8 1 +Response to manganese ion 0.8347587386549342 1.964654049406126 0.0494542916840765 1.0 0.7815937456234014 5 P02786,P30536,P05067 3 +Regulation of leukocyte mediated cytotoxicity 0.7924629657151804 1.9635588654226157 0.0495812716533485 1.0 0.7815937456234014 7 P11279,P46108,O15400,P01889,P04439 5 +Regulation of t cell mediated cytotoxicity 0.8723484848484866 1.9626806610568783 0.0496832916118781 1.0 0.7815937456234014 4 P04439,O15400,P01889 3 +Positive regulation of t cell mediated cytotoxicity 0.8723484848484866 1.9626806610568783 0.0496832916118781 1.0 0.7815937456234014 4 P04439,O15400,P01889 3 +Endoplasmic reticulum tubular network organization 0.726099806994976 1.956761518621217 0.0503755133101975 1.0 0.7815937456234014 9 P57088,Q9NQC3,Q9H6H4,Q15041,O95197 5 +Lipid storage 0.6550353255220098 1.95393189589433 0.0507092718798285 1.0 0.7815937456234014 12 P04062,Q8WTV0,Q9H4M9,P07686,Q9H6V9,P17900 6 +Notch signaling pathway 0.6460974316612372 1.9539064545070823 0.050712281114676 1.0 0.7815937456234014 13 Q9NWT6,P05067 2 +Neuron maturation 0.82142490525219 1.9523643857295696 0.0508949582117668 1.0 0.7815937456234014 6 O75503 1 +Sphingolipid biosynthetic process 0.6362499400332814 1.949290900090837 0.0512606946973102 1.0 0.7815937456234014 14 Q13510,P04062,O15270,O15269,Q06136,Q16739,Q96G23,O95470 8 +Membrane protein ectodomain proteolysis 0.7244569920070889 1.9488421612388585 0.0513142770405943 1.0 0.7815937456234014 9 Q8TCT8,O43847,Q92542,Q9NZ08 4 +Cartilage development 0.6628410605586339 1.9484019581182128 0.0513668857120341 1.0 0.7815937456234014 11 O75844 1 +Post translational protein modification 0.6622863217542302 1.9454155551654748 0.0517249840899487 1.0 0.7815937456234014 11 O75718,O60725,Q32P28 3 +Cytokine production involved in inflammatory response 0.8196492688524861 1.9449574256704552 0.0517801025845379 1.0 0.7815937456234014 6 Q8IV08 1 +Mitophagy 0.6431429295088505 1.9374467542650555 0.0526907561259823 1.0 0.7815937456234014 13 Q13501,P12235,O95140,P21796 4 +Sterol homeostasis 0.6916618363796426 1.9357051249988424 0.0529038264186876 1.0 0.7815937456234014 10 Q5BJF2,P61916,Q8WTV0 3 +Signal peptide processing 0.8655519618781462 1.935062298917329 0.0529826512327264 1.0 0.7815937456234014 4 O75503 1 +Cytochrome complex assembly 0.720969330425703 1.9320065436405067 0.0533586982198026 1.0 0.7815937456234014 9 O43819,P53701,Q15070,Q69YU5,Q9BRT2,Q6DKK2 6 +Endoplasmic reticulum calcium ion homeostasis 0.7529557814197979 1.930062034663468 0.0535991518186049 1.0 0.7815937456234014 8 O76024,P05067,P16615,Q9Y3D6,Q96A33 5 +Response to retinoic acid 0.7203777855090956 1.929147946350429 0.0537124981738816 1.0 0.7815937456234014 9 P11717 1 +Intracellular protein transmembrane transport 0.5961296979260465 1.928658601749463 0.0537732587828938 1.0 0.7815937456234014 20 Q15388,Q99595,O95831,O60830,O43615,Q15629,O14925,Q3ZCQ8 8 +Regulation of cholesterol biosynthetic process 0.8255005928456989 1.9263266657811675 0.054063597846599 1.0 0.7815937456234014 5 Q9UBM7,O75477,Q6P1A2 3 +Regulation of alcohol biosynthetic process 0.8255005928456989 1.9263266657811675 0.054063597846599 1.0 0.7815937456234014 5 Q9UBM7,O75477,Q6P1A2 3 +Cytoplasmic pattern recognition receptor signaling pathway in response to virus 0.6580626086585892 1.9226445386798667 0.0545247064691201 1.0 0.7815937456234014 11 O43657,Q9NUD5 2 +T cell mediated immunity 0.6888285035349392 1.9212613789631643 0.0546987635131634 1.0 0.7815937456234014 10 P04439,O15400,P01889,P53634 4 +Regulation of glial cell proliferation 0.9423123212527178 1.920635998655392 0.0547776134660411 1.0 0.7815937456234014 3 P30536 1 +Carbohydrate catabolic process 0.5589149443166589 1.9187898995744317 0.0550109286387563 1.0 0.7815937456234014 46 P10253,P16278,O00462,P08236,P05067,P07686,Q14108,Q9NUJ1,P17900 9 +Mucopolysaccharide metabolic process 0.750382282450843 1.9182329641831863 0.0550814781580022 1.0 0.7815937456234014 8 P15586,Q8NCH0,P16278,O43505 4 +Glutamate receptor signaling pathway 0.9405528209011724 1.9136740175704972 0.0556618209447306 1.0 0.7815937456234014 3 Q92542,P05067 2 +Regulation of fat cell differentiation 0.7491093149649377 1.9123762017346717 0.0558279582028926 1.0 0.7815937456234014 8 Q8N4Q0 1 +Lipoprotein catabolic process 0.8595438384424081 1.9105933097682248 0.0560568647978902 1.0 0.7815937456234014 4 P50897 1 +Protein depalmitoylation 0.8595438384424081 1.9105933097682248 0.0560568647978902 1.0 0.7815937456234014 4 P50897 1 +Protein targeting 0.4680098799270024 1.9098683581980287 0.0561501650340192 1.0 0.7815937456234014 98 Q99595,O95831,P30536,Q5JRX3,P55786,O14737,Q99496,O14925,Q14108,P43307,Q3ZCQ8,Q9Y5M8,Q10713,O60830,O43615,P51572,P27105,Q15041,P20645,Q9Y3D6,P46379,O96008,Q7L5D6,Q9NS69,O00560,O43681,O60725,Q15629,Q8N4H5,Q99523,Q15388,Q15005,Q7Z3B4,P51149,O95140 35 +Antigen processing and presentation of exogenous antigen 0.7784996755838036 1.9024629576259888 0.057110657105059 1.0 0.7815937456234014 7 Q99538,Q9UIQ6 2 +Response to hepatocyte growth factor 0.7467005021909449 1.901283480872629 0.0572648915967697 1.0 0.7815937456234014 8 O14786,Q06481,Q99538 3 +Modulation of excitatory postsynaptic potential 0.8194266964330637 1.9011037475909651 0.0572884248406553 1.0 0.7815937456234014 5 P05067 1 +L alpha amino acid transmembrane transport 0.7134028350629685 1.895374528567161 0.0580428007517019 1.0 0.7815937456234014 9 O75915,O60831,Q15041,Q15758,P08195,Q9Y619 6 +Neuron recognition 0.8178057354646513 1.8943620976460225 0.0581769637366729 1.0 0.7815937456234014 5 P35613,P05067 2 +Negative regulation of gliogenesis 0.935562136194872 1.8939090576349316 0.0582370820387665 1.0 0.7815937456234014 3 P30536 1 +Antigen processing and presentation of endogenous peptide antigen via mhc class i via er pathway 0.9341158652025732 1.8881764148678863 0.0590022709750188 1.0 0.7815937456234014 3 P01889,P10321 2 +Detection of external biotic stimulus 0.9341158652025728 1.8881764148678797 0.0590022709750197 1.0 0.7815937456234014 3 P01889,Q8WTV0 2 +Sphingosine biosynthetic process 0.8537878787878816 1.887104224863822 0.0591463085711958 1.0 0.7815937456234014 4 Q13510,P04062,O15269 3 +Protein catabolic process in the vacuole 0.852130922563667 1.8803340413281864 0.0600625666805638 1.0 0.7815937456234014 4 Q8N511,O14773 2 +Lysosomal protein catabolic process 0.852130922563667 1.8803340413281864 0.0600625666805638 1.0 0.7815937456234014 4 Q8N511,O14773 2 +Negative regulation of mrna catabolic process 0.587686454848126 1.8764446791424656 0.0605942443425935 1.0 0.7815937456234014 22 Q14103,O60506,Q14011,Q13151,Q99729,P35637,Q92804,Q06787 8 +Response to l glutamate 0.851021643285046 1.8757995319660277 0.060682812295326 1.0 0.7815937456234014 4 Q9UQB8 1 +Acute inflammatory response 0.8501213820819978 1.8721182201118705 0.061190249810664 1.0 0.7815937456234014 4 P42785,Q9BQE5 2 +Fatty acid transmembrane transport 0.8121688315677438 1.870884381292637 0.0613611083273553 1.0 0.7815937456234014 5 P23786 1 +Negative regulation of fat cell differentiation 0.8497993892821054 1.8708012740522637 0.0613726309700743 1.0 0.7815937456234014 4 Q8N4Q0 1 +Lipoprotein localization 0.9291934873154116 1.8686492537489976 0.0616716284675116 1.0 0.7815937456234014 3 O15260,A6NIH7 2 +T cell mediated cytotoxicity 0.800069334046384 1.862899014465088 0.0624764755127011 1.0 0.7815937456234014 6 P04439,O15400,P01889,P53634 4 +Phosphatidylcholine metabolic process 0.6772560986913183 1.8620284852756213 0.0625990751917964 1.0 0.7815937456234014 10 P35790,Q8NCC3,Q96N66,Q8WTV0 4 +Positive regulation of anion transport 0.8083860403993626 1.8551000257739865 0.0635819441307092 1.0 0.7815937456234014 5 P08183,P14174,Q15041 3 +Substrate dependent cell migration 0.7672262518930814 1.8528479475659672 0.0639041556131376 1.0 0.7815937456234014 7 O00560,O94813 2 +Regulation of tube size 0.7353537832041339 1.848854852376193 0.0644787743487842 1.0 0.7815937456234014 8 Q9HB40 1 +Bone resorption 0.7965663420745326 1.8481451311319488 0.0645813504390799 1.0 0.7815937456234014 6 O14773 1 +Cellular response to virus 0.5829401422098792 1.8467071203242331 0.064789599186096 1.0 0.7815937456234014 20 O43657,Q9NUD5,Q06787 3 +Nerve development 0.7955504322823395 1.8438622305651389 0.065203220679505 1.0 0.7815937456234014 6 Q9H061,P42892 2 +Peptide catabolic process 0.6732539998701925 1.8414550127144649 0.0655549073957313 1.0 0.7815937456234014 10 P55786,Q9UIQ6,P09960,P42892,O14773 5 +Negative regulation of calcium ion transmembrane transport 0.7334125987800084 1.8398564706496467 0.0657893121652459 1.0 0.7815937456234014 8 P21796 1 +Negative regulation of calcium ion transport 0.7334125987800084 1.8398564706496467 0.0657893121652459 1.0 0.7815937456234014 8 P21796 1 +Reproductive behavior 0.8390183714169707 1.8266272107877657 0.0677558392222685 1.0 0.7815937456234014 4 P05067 1 +Mating 0.8390183714169707 1.8266272107877657 0.0677558392222685 1.0 0.7815937456234014 4 P05067 1 +Mating behavior 0.8390183714169707 1.8266272107877657 0.0677558392222685 1.0 0.7815937456234014 4 P05067 1 +Cellular transition metal ion homeostasis 0.5797181829613727 1.8260123199351956 0.0678484061122421 1.0 0.7815937456234014 21 Q9Y487,P02786,Q8N511,P05067,Q8TAD4,Q15904 6 +Antigen processing and presentation of endogenous antigen 0.8013901338842344 1.8258477161874136 0.0678732035291691 1.0 0.7815937456234014 5 P04439,P01889,P10321 3 +Antigen processing and presentation of endogenous peptide antigen 0.8013901338842344 1.8258477161874136 0.0678732035291691 1.0 0.7815937456234014 5 P04439,P01889,P10321 3 +Vitamin d metabolic process 0.9177408831400372 1.8231228324668705 0.068284789181273 1.0 0.7815937456234014 3 Q99538 1 +Regulation of nitric oxide synthase activity 0.8006253845260005 1.8226453029205616 0.0683571294934837 1.0 0.7815937456234014 5 P06280 1 +Positive regulation of pinocytosis 0.9170484857476382 1.820366334182737 0.0687032357186532 1.0 0.7815937456234014 3 P50897 1 +Regulation of pinocytosis 0.9170484857476382 1.820366334182737 0.0687032357186532 1.0 0.7815937456234014 3 P50897 1 +Regulation of protein folding 0.8368714479457884 1.817812194278756 0.0690928422020755 1.0 0.7815937456234014 4 Q9H2J4,Q9UL15 2 +Positive regulation of receptor mediated endocytosis 0.6972642960301572 1.8167570906227184 0.0692543157455207 1.0 0.7815937456234014 9 P50897 1 +Amyloid precursor protein biosynthetic process 0.9157717663128704 1.8152824069824365 0.0694805212179254 1.0 0.7815937456234014 3 Q9NQX7 1 +Organic cation transport 0.7586923948416486 1.8151210764738168 0.0695053048906282 1.0 0.7815937456234014 7 Q70HW3,Q96QD8,O43772 3 +Camera type eye morphogenesis 0.7883150882630547 1.8133063476265336 0.0697845848187368 1.0 0.7815937456234014 6 O95140,P54802,Q15555 3 +Regulation of jnk cascade 0.6674647945931178 1.8116144394562883 0.0700457922497745 1.0 0.7815937456234014 10 P05067 1 +Receptor mediated endocytosis 0.5498365792130693 1.81138680734775 0.0700809966881446 1.0 0.7815937456234014 44 P11717,O75955,Q5VW38,P02786,P50897,O00560,P05067,Q9NR12,Q14108,Q06787 10 +Carbohydrate transmembrane transport 0.6365977136152372 1.8060292800503397 0.0709137661044825 1.0 0.7815937456234014 11 Q16625,Q06481 2 +Natural killer cell mediated immunity 0.6663402094633164 1.8058067991605051 0.0709485230658359 1.0 0.7815937456234014 10 P04439,P11279,P01889,P51809 4 +Positive regulation of jnk cascade 0.7953338904314292 1.800461733589452 0.0717877606377039 1.0 0.7815937456234014 5 P05067 1 +Hormone biosynthetic process 0.6932039224398056 1.796874533071454 0.0723555404539706 1.0 0.7815937456234014 9 Q53GQ0,P30536,Q8NBQ5,P16435,Q9UBM7 5 +Bone morphogenesis 0.7842702440327106 1.7961842590097237 0.0724652173205182 1.0 0.7815937456234014 6 O75844 1 +Calcium mediated signaling 0.6090366327583623 1.7937136188578044 0.0728588904453753 1.0 0.7815937456234014 14 Q9Y3D6,O75844 2 +Positive regulation of cell killing 0.7832270738867755 1.7917638202912536 0.0731708065595193 1.0 0.7815937456234014 6 P04439,P11279,O15400,P01889 4 +Purine nucleotide transport 0.7226085015946403 1.789621234177736 0.0735148225184543 1.0 0.7815937456234014 8 P12235,Q8TB61,P12236,P05141,Q99808,Q6NUK1 6 +Detection of stimulus 0.6335334597922592 1.7892611257554585 0.07357277155535 1.0 0.7815937456234014 11 P30536,P01889,Q8WTV0 3 +Cellular iron ion homeostasis 0.6164224124953905 1.7871957747287583 0.0739058519953981 1.0 0.7815937456234014 13 P02786,Q8N511,Q9Y487 3 +Mitochondrial transport 0.43362583531783 1.7863071432029685 0.0740495409605623 1.0 0.7815937456234014 79 Q99595,P12235,O95831,P30536,Q5JRX3,P55786,O14737,Q99496,P48506,Q9UBX3,Q9UJZ1,O14925,Q3ZCQ8,Q10713,O60830,P45880,O43615,P52789,P51572,Q15070,Q9Y3D6,O75964,O96008,Q9NS69,P24539,O43772,Q8N4H5,Q15388,P23786,Q96EK5,O95140 31 +Steroid catabolic process 0.908499809840629 1.7862964594202977 0.0740512698833322 1.0 0.7815937456234014 3 Q8WTV0 1 +Negative regulation of neuron projection development 0.5812681216931478 1.7841487401966984 0.074399499100884 1.0 0.7815937456234014 17 O14786,Q9NQX7,Q15375,Q9UL15,Q9NR77,Q96G23 6 +Regulation of plasma lipoprotein particle levels 0.6322499312909751 1.782228569506797 0.0747119656607091 1.0 0.7815937456234014 11 P38571,Q8WTV0,P09601,Q9H4M9,Q92945,Q6P1A2 6 +Negative regulation of blood pressure 0.8281594012948725 1.7819811215518464 0.0747523103628933 1.0 0.7815937456234014 4 Q9HB40 1 +Neutral amino acid transport 0.7907709685050907 1.781297460448681 0.0748638691554806 1.0 0.7815937456234014 5 Q96QD8,Q15758,P08195 3 +Bone remodeling 0.7503344403991278 1.778032971326099 0.0753984398731613 1.0 0.7815937456234014 7 P02786,O14773 2 +Chloride transmembrane transport 0.7892954585665779 1.7750934385653994 0.0758824602156855 1.0 0.7815937456234014 5 P51798,Q9UHG3,P51790 3 +Regulation of natural killer cell mediated immunity 0.7891835084150657 1.7746225895419534 0.0759602247663315 1.0 0.7815937456234014 5 P04439,P11279,P01889 3 +Glucose import 0.6601880808543944 1.773973054801179 0.0760676074167616 1.0 0.7815937456234014 10 Q16625,Q06481 2 +Cellular response to increased oxygen levels 0.7490126275438178 1.7721550350046194 0.0763688253558254 1.0 0.7815937456234014 7 Q8N511,Q9Y487 2 +Leukotriene metabolic process 0.8257575757575775 1.7720861114920017 0.0763802640331601 1.0 0.7815937456234014 4 Q99735,P09960,O14880 3 +Protein localization to membrane raft 0.904581597879591 1.7706586998114235 0.0766174742641927 1.0 0.7815937456234014 3 P05026,O75955 2 +Toll like receptor 3 signaling pathway 0.9045815978795888 1.7706586998114142 0.0766174742641943 1.0 0.7815937456234014 3 O75955,Q5KU26 2 +Modulation by host of viral genome replication 0.7185103434284985 1.7704991550062796 0.0766440250295237 1.0 0.7815937456234014 8 P27105 1 +Regulation of lymphocyte mediated immunity 0.570436598695423 1.7698938655464496 0.0767448229401028 1.0 0.7815937456234014 19 P11279,P46108,O15400,P01889,P02786,P04439 6 +Positive regulation of lymphocyte mediated immunity 0.5961427289129212 1.7686744829802803 0.0769482129671146 1.0 0.7815937456234014 15 P11279,O15400,P01889,P02786,P04439 5 +Protein targeting to membrane 0.565777668793073 1.7665537503369957 0.0773029923384891 1.0 0.7815937456234014 31 O00560,P27105,Q15041,O60725,P46379,Q15629,Q9Y3D6,P43307 8 +Organic hydroxy compound metabolic process 0.4589450360482054 1.763157022834625 0.0778740100022745 1.0 0.7815937456234014 102 Q13510,O15270,P07858,Q9BQE5,P05067,Q16850,Q99538,O75874,Q10713,O14975,P21964,P61916,O15269,O75845,O75477,Q14739,Q9UKR5,Q6P1A2,P48449,Q9UBM7,P04062,Q8WTV0,P35270,Q15392,Q9H2C2,P51648,P38571,Q14534,O15118,P16435,P48735 31 +Retinal ganglion cell axon guidance 0.82298196274778 1.760642352413888 0.0782989555236404 1.0 0.7815937456234014 4 Q15375,O94813 2 +Peptidyl proline hydroxylation 0.7756898253639156 1.7597687615876592 0.0784470216563295 1.0 0.7815937456234014 6 O75718,Q32P28 2 +Glial cell migration 0.61971465244579 1.7585983725341028 0.0786457496159769 1.0 0.7815937456234014 12 P30536,P07686,Q96G23 3 +Sphingomyelin biosynthetic process 0.8224527529943597 1.7584593741270036 0.0786693782485961 1.0 0.7815937456234014 4 O15269,O15270 2 +Transition metal ion homeostasis 0.5684550283674301 1.7560608400878528 0.0790780207191124 1.0 0.7815937456234014 24 P30519,Q9Y487,P02786,Q8N511,P05067,Q15904 6 +Collateral sprouting 0.8212121212121266 1.7533404697245254 0.0795435827793031 1.0 0.7815937456234014 4 Q15375,P53990,P05067 3 +Regulation of response to extracellular stimulus 0.8207144360151333 1.7512864768522898 0.0798965759383594 1.0 0.7815937456234014 4 P80303 1 +Negative regulation of cell killing 0.8199519404888109 1.7481390114299222 0.0804399592224907 1.0 0.7815937456234014 4 P04439,P01889 2 +Negative regulation of regulated secretory pathway 0.8196969696969731 1.747086375766028 0.0806223563141825 1.0 0.7815937456234014 4 P09601,P04899,Q06787 3 +Regulation of t cell migration 0.8169033669630636 1.7355480530734535 0.082643777866789 1.0 0.7815937456234014 4 P05067 1 +Cholesterol efflux 0.7797074600710208 1.7346985585784374 0.0827942117578195 1.0 0.7815937456234014 5 P61916,Q8WTV0 2 +Regulation of neural precursor cell proliferation 0.652496626642399 1.734026522401695 0.0829133773608403 1.0 0.7815937456234014 10 Q06481,P55209 2 +Potassium ion import across plasma membrane 0.7793010131434098 1.7329831240470164 0.0830986683615284 1.0 0.7815937456234014 5 P05026,P55011,P05023 3 +Potassium ion homeostasis 0.7793010131434098 1.7329831240470164 0.0830986683615284 1.0 0.7815937456234014 5 P05026,P55011,P05023 3 +Glycolipid transport 0.8945829242994039 1.7306937553415054 0.083506399620119 1.0 0.7815937456234014 3 P07602 1 +Regulation of mitochondrial fusion 0.7786982740434331 1.7304387756842996 0.0835519110098963 1.0 0.7815937456234014 5 P02786 1 +Macrophage activation 0.7782782094692191 1.7286652354022614 0.0838690267524358 1.0 0.7815937456234014 5 P05067 1 +Mitochondrial fusion 0.62197537459734 1.725746476900851 0.0843930326560382 1.0 0.7815937456234014 11 Q8N2A8,P02786,Q9UJZ1,Q9Y3D6,O95140 5 +Cellular response to exogenous dsrna 0.7676155287020662 1.725386364365544 0.0844578670026154 1.0 0.7815937456234014 6 O75955,Q9NUD5,Q5KU26,Q7Z434 4 +Positive regulation of organic acid transport 0.7773490804170293 1.7247414668059324 0.0845740745050345 1.0 0.7815937456234014 5 P14174,Q15041 2 +Prostate gland development 0.7772263326209279 1.7242230003294854 0.084667593498396 1.0 0.7815937456234014 5 P07602 1 +Myoblast differentiation 0.7381071713548135 1.723532074350357 0.0847923500812184 1.0 0.7815937456234014 7 Q9NWT6 1 +Selective autophagy 0.5630361773140453 1.7201084558085795 0.0854127289797903 1.0 0.7815937456234014 23 P12235,O15270,P53365,O15269,Q13501,P21796,O95140 7 +Glial cell development 0.5878984043749671 1.720016802939326 0.0854293872900064 1.0 0.7815937456234014 15 Q92542,P05067 2 +Response to amyloid beta 0.7656928527025839 1.717182955954173 0.0859457487140515 1.0 0.7815937456234014 6 P05067 1 +Cellular response to amyloid beta 0.7656928527025839 1.717182955954173 0.0859457487140515 1.0 0.7815937456234014 6 P05067 1 +Steroid biosynthetic process 0.5434099087147213 1.7143601745164678 0.0864625979733744 1.0 0.7815937456234014 41 Q13510,P30536,Q8NBQ5,Q16850,O14975,O75845,O75477,Q14739,Q9UKR5,Q6P1A2,P48449,Q9UBM7,P22059,Q15392,P37268,Q9H2C2,Q9UHQ9,Q53GQ0,Q14534,P16435 20 +Adaptive immune response 0.5558634741292738 1.7134476215696597 0.0866302216650309 1.0 0.7815937456234014 33 O15400,P01889,P02786,Q96FW1,P04439,Q07021,P53634,P10321,Q9UQ84,Q9NZ08 10 +Negative regulation of natural killer cell mediated immunity 0.8898144642181024 1.7116052997439402 0.0869694309912854 1.0 0.7815937456234014 3 P04439,P01889 2 +Iron ion homeostasis 0.5777388839136277 1.710046284992262 0.0872573144462189 1.0 0.7815937456234014 16 P02786,Q8N511,Q15904,Q9Y487 4 +Cellular potassium ion homeostasis 0.8105784904274784 1.7093909548419066 0.0873785552833747 1.0 0.7815937456234014 4 P05026,P55011 2 +Cellular sodium ion homeostasis 0.8105784904274784 1.7093909548419066 0.0873785552833747 1.0 0.7815937456234014 4 P05026,P55011 2 +Sulfur compound catabolic process 0.7345672854815494 1.707700794491543 0.0876918746647725 1.0 0.7815937456234014 7 P15586 1 +Regulation of gliogenesis 0.6749994039737535 1.7072343733438191 0.0877784984874265 1.0 0.7815937456234014 9 P30536 1 +Cell recognition 0.5607663591989407 1.7059597200638352 0.0880155794080905 1.0 0.7815937456234014 21 Q8WTV0,P45880,P35613,P05067,Q5KU26 5 +Lipid homeostasis 0.5604863317828909 1.7044567087241898 0.0882957972294338 1.0 0.7815937456234014 24 Q96CP7,Q5BJF2,Q8WTV0,Q9Y5P4,P61916,Q15067,O15260,O15118,Q9HCL2 9 +Negative regulation of lymphocyte mediated immunity 0.8084987463899673 1.700779992655219 0.0889843075810483 1.0 0.7815937456234014 4 P04439,P01889 2 +Lipophagy 0.8071542086935336 1.6952104937217136 0.090035496944469 1.0 0.7815937456234014 4 O15269,O15270 2 +Collagen metabolic process 0.6721079210852485 1.692922935102814 0.0904701371004803 1.0 0.7815937456234014 9 P07858,Q32P28 2 +Neuron projection organization 0.5586653290301544 1.6925546073868325 0.0905402775363168 1.0 0.7815937456234014 21 Q99538,P05067 2 +Carbohydrate transport 0.5992439548262916 1.6893001800081793 0.0911619189126586 1.0 0.7815937456234014 13 Q16625,Q06481 2 +Transition metal ion transport 0.5986472704261516 1.685881944809258 0.091818540198771 1.0 0.7815937456234014 13 P02786,Q8TAD4,O15173,Q9HD20 4 +Positive regulation of mitochondrial translation 0.7680987217101017 1.685608132582258 0.091871301767141 1.0 0.7815937456234014 5 Q07021,Q567V2 2 +Nucleotide transmembrane transport 0.7292522902045421 1.683887010446657 0.0922035071650109 1.0 0.7815937456234014 7 P12235,Q8TB61,Q9H2D1,P12236,P05141 5 +Neutral lipid biosynthetic process 0.7561996259848827 1.6765890686318938 0.0936228658279594 1.0 0.7815937456234014 6 Q8NCC3,Q8WTV0 2 +Steroid hormone biosynthetic process 0.7275820434284439 1.676392748356341 0.0936612884019683 1.0 0.7815937456234014 7 P30536,Q9UBM7,Q8NBQ5 3 +Fatty acid transport 0.5887180948019324 1.6758178900020335 0.0937738688232274 1.0 0.7815937456234014 14 P23786,Q9Y3D6,O14975 3 +Ovulation cycle 0.7655986365073826 1.6750106003774732 0.09393215185079 1.0 0.7815937456234014 5 O94813 1 +Cranial nerve development 0.8010150892549293 1.669755081746023 0.0949678308237405 1.0 0.7815937456234014 4 Q9H061 1 +Regulation of t cell mediated immunity 0.7251667309591495 1.665546441852764 0.0958037862041156 1.0 0.7815937456234014 7 P04439,O15400,P01889 3 +Kidney epithelium development 0.6946352877228377 1.658383563351574 0.0972400720458357 1.0 0.7815937456234014 8 Q15375,O94813 2 +Monocyte chemotaxis 0.7232531654708759 1.656945799759399 0.0975304335823021 1.0 0.7815937456234014 7 Q99538 1 +Pteridine containing compound metabolic process 0.560230583010718 1.6549629605008946 0.0979320114849997 1.0 0.7815937456234014 17 Q92820,Q9H2D1 2 +Regulation of leukocyte chemotaxis 0.593018855562379 1.653580218147436 0.0982128347605881 1.0 0.7815937456234014 13 Q07021,Q99538,O00429,O94813 4 +Cell maturation 0.5518683961732889 1.6481291280835322 0.0993261762097903 1.0 0.7815937456234014 22 P04062,O75503,Q8N2A8,P05067,Q9Y5A9 5 +Purine containing compound transmembrane transport 0.7205533037353157 1.644799906497323 0.1000110814764596 1.0 0.7815937456234014 7 P12235,Q8TB61,P12236,P05141,Q99808 5 +Regulation of viral induced cytoplasmic pattern recognition receptor signaling pathway 0.7204845932326925 1.6444906278964593 0.1000748986363697 1.0 0.7815937456234014 7 O43657,Q9NUD5 2 +Protein localization to mitochondrion 0.5000082115025336 1.6420995374537586 0.1005693775365279 1.0 0.7815937456234014 54 Q99595,O95831,P30536,Q5JRX3,P55786,O14737,Q99496,O14925,Q3ZCQ8,Q10713,O60830,O43615,P52789,O00429,P51572,Q15070,Q9Y3D6,O96008,P11233,Q9NS69,Q8N4H5,Q15388,O95140 23 +Positive regulation of chemokine production 0.7198795579989431 1.6417668902235665 0.1006383232115157 1.0 0.7815937456234014 7 P14174,Q7Z434,P05067 3 +Chemokine production 0.7198795579989431 1.6417668902235665 0.1006383232115157 1.0 0.7815937456234014 7 P14174,Q7Z434,P05067 3 +Bleb assembly 0.8710544235402117 1.6363449253501878 0.1017674186906609 1.0 0.7815937456234014 3 Q9NR77 1 +Negative regulation of leukocyte mediated immunity 0.7559537377159278 1.6340460330558435 0.1022491851936755 1.0 0.7815937456234014 5 P04439,P46108,P01889 3 +Myotube differentiation 0.5895226547128576 1.6334628432156058 0.1023716893120461 1.0 0.7815937456234014 13 Q99523,O75955,Q9H4M9,Q9H7B4,Q8IV08 5 +Negative regulation of autophagy 0.547817717421759 1.6302847245599712 0.1030413345033784 1.0 0.7815937456234014 18 P10619,P30536,O15118 3 +Retina morphogenesis in camera type eye 0.7913269818217112 1.6295030523810494 0.1032065692368136 1.0 0.7815937456234014 4 P54802,Q15555 2 +Lipid catabolic process 0.4565776435785799 1.6290811004967434 0.1032958515684026 1.0 0.7815937456234014 65 Q13510,Q8NHP8,P50897,P06280,Q8NBQ5,O75874,Q9H6V9,P06865,Q8N2A8,O14975,Q9BWD1,P04062,Q8WTV0,Q8NCC3,P04066,P17900,P23786,Q15067,P07686 19 +Regulation of systemic arterial blood pressure 0.744324045769737 1.6256036273022318 0.1040340030836071 1.0 0.7815937456234014 6 P42785,P42892 2 +Phosphatidylcholine catabolic process 0.9723694171082512 1.624081907452731 0.1043583287812077 1.0 0.7815937456234014 2 Q8WTV0 1 +Regulation of defense response 0.4212177306152375 1.6226695172865686 0.1046600710182088 1.0 0.7815937456234014 81 O43657,Q96PK6,P05067,Q7Z434,Q9NZ08,P01889,P46108,P04439,Q99735,O75844,Q6P1A2,P04062,Q06481,P53634,P28070,P11279,P51809,Q07021,Q9Y5A9,Q9NUD5 20 +Anatomical structure maturation 0.5470545808344435 1.6218814849648977 0.104828726640024 1.0 0.7815937456234014 27 O75787,O75503,Q8N2A8,P05067 4 +Membrane invagination 0.6578100489885921 1.6218675158237477 0.1048317182775142 1.0 0.7815937456234014 9 Q06481,P51790 2 +Glyoxylate metabolic process 0.86737621568417 1.6215614398470952 0.1048972846592306 1.0 0.7815937456234014 3 P48735 1 +Leukotriene biosynthetic process 0.8670957970465742 1.6204340443933496 0.1051390716745614 1.0 0.7815937456234014 3 Q99735,P09960 2 +Positive regulation of neural precursor cell proliferation 0.7523670988813791 1.6187805679001024 0.1054944845827223 1.0 0.7815937456234014 5 P55209 1 +Protein targeting to mitochondrion 0.5265136962334996 1.6187228969564005 0.1055068980696039 1.0 0.7815937456234014 43 Q99595,O95831,P30536,Q5JRX3,P55786,O14737,Q99496,O14925,Q3ZCQ8,Q10713,O60830,O43615,P51572,Q9Y3D6,O96008,Q9NS69,Q8N4H5,Q15388,O95140 19 +Skeletal system morphogenesis 0.5707917377879681 1.6182617396524792 0.1056062023998236 1.0 0.7815937456234014 15 Q92896,O75844,O95470,P16435 4 +Respiratory chain complex iii assembly 0.788370324358006 1.6171999350458597 0.1058351303648588 1.0 0.7815937456234014 4 Q69YU5,Q6DKK2 2 +Response to thyroid hormone 0.6858002601745237 1.6165956606980412 0.1059655892004065 1.0 0.7815937456234014 8 P07858 1 +Response to catecholamine 0.5943604248277977 1.6158580782612604 0.1061250011767989 1.0 0.7815937456234014 12 P05067 1 +Export across plasma membrane 0.7125497809940406 1.6087185542705136 0.1076778968171938 1.0 0.7815937456234014 7 P05026,P08183,P35670 3 +Fucose metabolic process 0.9682059046177132 1.60703621727939 0.108046423516257 1.0 0.7815937456234014 2 Q9BTY2 1 +Microglial cell activation 0.9678274034822096 1.6054864449286408 0.1083867939046254 1.0 0.7815937456234014 2 P05067 1 +Ceramide biosynthetic process 0.6540512578693612 1.6031098093647944 0.1089104126923783 1.0 0.7815937456234014 9 Q13510,P04062,O15269,Q16739,Q96G23 5 +Positive regulation of adaptive immune response 0.5839896146853432 1.6015441725269128 0.1092564445551853 1.0 0.7815937456234014 13 P02786,O15400,P01889,P04439 4 +Tissue remodeling 0.5832948634937014 1.5975293683578071 0.1101477566175053 1.0 0.7815937456234014 13 P02786,P38571,O14773 3 +Phagocytosis recognition 0.9655563966691898 1.5961873081485165 0.1104469803818759 1.0 0.7815937456234014 2 Q8WTV0 1 +Pinocytosis 0.7374657418545436 1.5960588848210258 0.1104756470836392 1.0 0.7815937456234014 6 P50897,Q06481 2 +O glycan processing 0.7829545454545509 1.5946423203070168 0.1107922431956378 1.0 0.7815937456234014 4 Q10472,O43505,Q10471 3 +Regulation of oxidoreductase activity 0.5664034061595078 1.5919901393902398 0.1113869201725266 1.0 0.7815937456234014 15 P04899,P06280,Q8WTV0 3 +Macrophage differentiation 0.7459882639811592 1.5915895783809744 0.1114769532623838 1.0 0.7815937456234014 5 P05067 1 +Phosphatidylcholine acyl chain remodeling 0.8586182380694725 1.5863298709554807 0.1126644996320767 1.0 0.7815937456234014 3 Q96N66 1 +Positive regulation of t cell mediated immunity 0.7346821818032548 1.5840473776082742 0.1131829380164579 1.0 0.7815937456234014 6 P04439,O15400,P01889 3 +Vascular transport 0.6500404098805449 1.5830594089177727 0.1134079242107193 1.0 0.7815937456234014 9 P02786,P55011,P53985,Q99808,Q96QD8,P08183 6 +Multi multicellular organism process 0.5414614730021685 1.5808540048491748 0.1139114230781674 1.0 0.7815937456234014 25 P07858,Q9BQE5,P35613,Q9UIQ6,Q07021,P07686,Q96GC9 7 +Intermembrane lipid transfer 0.7062630103438055 1.580298842844292 0.1140384447508098 1.0 0.7815937456234014 7 P30536,P61916 2 +Acute phase response 0.961014383043148 1.5775868484436584 0.1146605556892153 1.0 0.7815937456234014 2 Q9BQE5 1 +Proteoglycan biosynthetic process 0.7786401217212973 1.5766527180437029 0.1148754553744795 1.0 0.7815937456234014 4 Q8NCH0 1 +Proteoglycan metabolic process 0.7786401217212973 1.5766527180437029 0.1148754553744795 1.0 0.7815937456234014 4 Q8NCH0 1 +Regulation of mitophagy 0.7414259644266238 1.5721103714591569 0.1159249566144002 1.0 0.7815937456234014 5 P21796 1 +Serine transport 0.7775061621004038 1.571921772032239 0.115968694589327 1.0 0.7815937456234014 4 Q96QD8,Q15758 2 +Lymphocyte migration 0.6754075931119649 1.5672430754907805 0.1170578853990518 1.0 0.7815937456234014 8 P04062,P46108,P05067 3 +Aminoglycan biosynthetic process 0.7033520830014798 1.5671172022791482 0.1170872989945071 1.0 0.7815937456234014 7 Q8NCH0,O43505,P06865 3 +Folic acid containing compound metabolic process 0.5770857834354313 1.561580456643857 0.1183868564185335 1.0 0.7815937456234014 13 Q9H2D1 1 +Intracellular sterol transport 0.7016294684239721 1.5593100022841684 0.118923025492265 1.0 0.7815937456234014 7 P61916,O15118 2 +Glycoprotein metabolic process 0.5224320470554623 1.5586377512518763 0.1190821426434454 1.0 0.7815937456234014 41 Q10472,Q9NQX7,O00462,Q8NCH0,Q10471,Q8N6G5,Q9BV10,O15118,O60502,Q92542,Q9BT22,O00754,O43505 13 +Regulation of nik nf kappab signaling 0.5525442373788496 1.556848981898838 0.1195063446573316 1.0 0.7815937456234014 16 O43657 1 +Positive regulation of leukocyte chemotaxis 0.6187333062375775 1.5567991283659746 0.1195181842288795 1.0 0.7815937456234014 10 Q07021,Q99538 2 +Modified amino acid transport 0.7735292313368873 1.5553210705668898 0.1198696215816734 1.0 0.7815937456234014 4 Q9H2D1,O43772 2 +Regulation of neutrophil migration 0.7277121337412775 1.553920484751575 0.1202033847783674 1.0 0.7815937456234014 6 Q07021,O94813 2 +Regulation of neutrophil chemotaxis 0.7277121337412775 1.553920484751575 0.1202033847783674 1.0 0.7815937456234014 6 Q07021,O94813 2 +Eye photoreceptor cell differentiation 0.7724923980007166 1.5509908927841145 0.1209038664851258 1.0 0.7815937456234014 4 P54802,Q15555 2 +Epithelial cell differentiation involved in prostate gland development 0.8493838951993211 1.5491396414535017 0.1213481552693127 1.0 0.7815937456234014 3 P07602 1 +Histone h3 k9 acetylation 0.7715377159864433 1.5470030301985105 0.1218625149609002 1.0 0.7815937456234014 4 Q14012,Q03164 2 +Cellular copper ion homeostasis 0.7355337736883676 1.5469155606525795 0.1218836083104424 1.0 0.7815937456234014 5 P35670,P05067 2 +Copper ion homeostasis 0.7355337736883676 1.5469155606525795 0.1218836083104424 1.0 0.7815937456234014 5 P35670,P05067 2 +Amino acid import across plasma membrane 0.7347633643351754 1.543618274894602 0.1226808351570589 1.0 0.7815937456234014 5 Q15758,Q15041,P08195 3 +Neuronal action potential 0.7705653654872261 1.5429406066459814 0.1228451872142246 1.0 0.7815937456234014 4 Q06787 1 +Negative regulation of transmembrane transport 0.533890102470606 1.538312045699055 0.1239723358856024 1.0 0.7815937456234014 19 P21796,Q06481 2 +Regulation of lymphocyte migration 0.7331602398939142 1.5367548329942673 0.1243533578493356 1.0 0.7815937456234014 5 P05067 1 +Walking behavior 0.84589170768649 1.535065511821401 0.1247677367749466 1.0 0.7815937456234014 3 O75844,O15118 2 +Regulation of defense response to virus 0.5647110940169904 1.5346852407852327 0.1248611629634428 1.0 0.7815937456234014 14 O43657,O75844 2 +Negative chemotaxis 0.9500378501135504 1.532629338251418 0.1253672085535995 1.0 0.7815937456234014 2 Q15375 1 +Positive regulation of dendritic spine development 0.5870295297808914 1.5312346358101938 0.1257114135218229 1.0 0.7815937456234014 11 Q9UQB8,Q06787 2 +Sterol biosynthetic process 0.5339017411782027 1.530286126113304 0.1259459208970994 1.0 0.7815937456234014 24 Q14534,O75477,O75845,Q15392,Q16850,Q14739,P37268,Q9UKR5,Q9H2C2,Q6P1A2,P16435,P48449,Q9UBM7 13 +Positive regulation of inflammatory response 0.5867578876902445 1.5297087193836778 0.1260888443984293 1.0 0.7815937456234014 11 P51809,P53634,P05067 3 +Glycerophospholipid catabolic process 0.7219943284464725 1.529154233424281 0.1262262132739149 1.0 0.7815937456234014 6 Q8WTV0 1 +Regulation of cholesterol metabolic process 0.6667502242610148 1.5259743282594385 0.1270162579896634 1.0 0.7815937456234014 8 Q9H2C2,Q9UBM7,O75477,Q6P1A2 4 +Production of molecular mediator involved in inflammatory response 0.6119058556727026 1.5206077373022318 0.128358303999462 1.0 0.7815937456234014 10 Q8IV08,Q06481 2 +Inflammatory response 0.4721916791861056 1.5179503091403386 0.1290269259036534 1.0 0.7815937456234014 58 P38571,P14174,P04062,Q06481,P09601,P02786,P60900,Q9BQE5,Q13151,P05067,P51809,Q99735,P42785,Q6P1A2,P53634,P28070,Q8N2K0,Q8IV08 18 +Response to arsenic containing substance 0.5687957326070834 1.5133957960512363 0.1301791522181092 1.0 0.7815937456234014 13 P09601,O00571,P48506,P36551,Q96QD8,P07196,P09651,Q9BWF3 8 +Calcium ion import 0.6099710432409367 1.51033111688782 0.1309589555586563 1.0 0.7815937456234014 10 P21796 1 +Negative regulation of glial cell proliferation 0.9436033308099924 1.5062755252366873 0.1319964583363959 1.0 0.7815937456234014 2 P30536 1 +Glycosylceramide metabolic process 0.7616698257112842 1.5057417477132955 0.1321334824312385 1.0 0.7815937456234014 4 Q16739,P06280 2 +Transmembrane transport 0.5151401573223324 1.5057156196927348 0.1321401924888448 1.0 0.7815937456234014 185 Q99595,Q8TB61,P12235,O95831,Q8IXU6,Q9UDW1,P05067,P53985,Q96ES6,P21796,Q9UBX3,Q9H2V7,Q9C0H2,P08195,Q9Y619,P08183,O14925,Q06787,O60830,P45880,O43615,P51798,P55011,P27105,P51790,Q15041,Q99808,Q00325,O75844,P61421,P16615,P35670,Q96GC9,O75964,P05026,P62942,P04062,Q9H2D1,Q06481,Q9UHG3,Q8WTV0,Q9NS69,O60831,P24539,Q6P4A7,Q15758,Q16625,Q15629,Q6P4Q7,O43772,Q70HW3,Q96H78,Q8TAD4,Q96NB2,Q9Y277,O00186,Q99523,P23786,Q15388,P12236,Q13423,Q5T1Q4,Q9HD20,Q9Y6M7,Q96QD8,O95563 66 +Positive regulation of protein targeting to membrane 0.7161498210016063 1.5037924412024577 0.1326348180608054 1.0 0.7815937456234014 6 P27105 1 +Positive regulation of leukocyte mediated immunity 0.5292129773378315 1.5026876234085014 0.1329196157660477 1.0 0.7815937456234014 21 P11279,O15400,P01889,P02786,P04439,Q9NUQ9 6 +Modification of postsynaptic actin cytoskeleton 0.7607692161445494 1.5019724006509858 0.1331042367493748 1.0 0.7815937456234014 4 Q9UQB8 1 +Adipose tissue development 0.6616295798693328 1.5015002883603707 0.1332262121629004 1.0 0.7815937456234014 8 O15173,P43490,O15270 3 +Membrane repolarization 0.6884702835672947 1.499512361603433 0.1337407642465464 1.0 0.7815937456234014 7 O75844 1 +Hormone catabolic process 0.8370098465762794 1.499250099128221 0.133808762527857 1.0 0.7815937456234014 3 P42892 1 +Regulation of axon guidance 0.83688289978273 1.4987380147991984 0.1339416106299711 1.0 0.7815937456234014 3 O94813 1 +Regulation of systemic arterial blood pressure mediated by a chemical signal 0.7598794805611048 1.4982480128286186 0.1340688254833937 1.0 0.7815937456234014 4 P42892 1 +Myeloid leukocyte differentiation 0.5284712450689844 1.4960148966840756 0.1346497732627334 1.0 0.7815937456234014 22 P02786,Q14739,Q15904,P05067 4 +Regulation of autophagy 0.4031195682160133 1.4892797638052215 0.1364137142117085 1.0 0.7815937456234014 76 P12235,P04062,Q9Y487,Q9NNW5,Q96DM3,P10619,P30536,O15269,O00429,P07602,P21796,O75844,O15118,Q93050,Q9NZJ7 15 +Cartilage development involved in endochondral bone morphogenesis 0.7576582447139566 1.4889476906891244 0.1365011438189123 1.0 0.7815937456234014 4 O75844 1 +Endochondral bone morphogenesis 0.7576582447139566 1.4889476906891244 0.1365011438189123 1.0 0.7815937456234014 4 O75844 1 +Positive regulation of anion transmembrane transport 0.8343455983677394 1.488501998285768 0.1366185555541266 1.0 0.7815937456234014 3 P08183 1 +Mitochondrial electron transport ubiquinol to cytochrome c 0.8343353749187634 1.488460751285685 0.1366294254664022 1.0 0.7815937456234014 3 Q9UDW1 1 +Endoplasmic reticulum organization 0.5188986035092298 1.4864014357992472 0.1371729702768032 1.0 0.7815937456234014 37 P57088,Q7L5D6,Q9Y5P4,Q9H6H4,O00429,O43681,Q15041,Q9NPA0,Q15629,Q8NFQ8,Q6P1A2,Q96A33,P46379,O95197,Q9P2W9,Q00765 16 +C4 dicarboxylate transport 0.7119054669212342 1.4853457418447185 0.1374522606902708 1.0 0.7815937456234014 6 P55011,Q9UBX3,Q02978,Q15758 4 +Cytoplasmic pattern recognition receptor signaling pathway 0.5553096607438508 1.4789015306191693 0.1391666342196509 1.0 0.7815937456234014 14 O43657,Q9NUD5 2 +Gliogenesis 0.5061910317453641 1.4788657086938628 0.1391762098408662 1.0 0.7815937456234014 44 P04062,Q96N66,P30536,P05067,Q96P11,P07686,Q96G23,Q92542 8 +Positive regulation of chemotaxis 0.5475783613995747 1.4785397645297826 0.1392633618523009 1.0 0.7815937456234014 15 Q07021,O14786,O94813,Q99538 4 +Regulation of systemic arterial blood pressure by hormone 0.9367903103709294 1.4783764761723113 0.1393070382188228 1.0 0.7815937456234014 2 P42892 1 +Response to food 0.7188653922346819 1.4754286588000092 0.1400973351837653 1.0 0.7815937456234014 5 P80303,Q9UMX5 2 +Bile acid metabolic process 0.6559617731917972 1.474357197048523 0.1403854425606914 1.0 0.7815937456234014 8 O15118,O14975 2 +Protein targeting to lysosome 0.6281746638186544 1.473145005830584 0.1407119401252246 1.0 0.7815937456234014 9 Q99523,Q14108 2 +Regulation of mitochondrial gene expression 0.6280215627625402 1.4723719378153883 0.1409204667962467 1.0 0.7815937456234014 9 Q07021,Q567V2 2 +Positive regulation of mitochondrion organization 0.5237699092912963 1.469898062608424 0.1415893643798906 1.0 0.7815937456234014 20 P12235,P11233,Q8N2A8,O00429,O14737,P21796,Q9Y3D6 7 +Regulation of response to food 0.9345193035579088 1.469078629049945 0.1418114635512026 1.0 0.7815937456234014 2 P80303 1 +Regulation of appetite 0.9345193035579088 1.469078629049945 0.1418114635512026 1.0 0.7815937456234014 2 P80303 1 +Negative regulation of response to food 0.9345193035579088 1.469078629049945 0.1418114635512026 1.0 0.7815937456234014 2 P80303 1 +Protection from natural killer cell mediated cytotoxicity 0.933762301286904 1.4659796012502446 0.1426538441969165 1.0 0.7815937456234014 2 P01889 1 +Detection of other organism 0.933762301286904 1.4659796012502446 0.1426538441969165 1.0 0.7815937456234014 2 P01889 1 +Antigen processing and presentation of exogenous peptide antigen via mhc class i 0.9337623012869029 1.4659796012502395 0.1426538441969178 1.0 0.7815937456234014 2 Q9UIQ6 1 +Peroxisome fission 0.8279616725634531 1.46274111784671 0.143538230472024 1.0 0.7815937456234014 3 Q9Y3D6 1 +Regulation of mitochondrial fission 0.6535008411473675 1.462554652271745 0.1435892794675726 1.0 0.7815937456234014 8 Q9Y3D6,P11233,O00429 3 +Female sex differentiation 0.6534161720024381 1.4621484004649692 0.1437005479279136 1.0 0.7815937456234014 8 O75874,O94813 2 +Development of primary female sexual characteristics 0.6534161720024381 1.4621484004649692 0.1437005479279136 1.0 0.7815937456234014 8 O75874,O94813 2 +Response to copper ion 0.7155561273706506 1.4612012635008225 0.1439602164090452 1.0 0.7815937456234014 5 P02786,P05067 2 +Negative regulation of nervous system development 0.5446211439075027 1.4606109164520953 0.1441222487489108 1.0 0.7815937456234014 15 Q15375,P30536,Q06481,Q96G23 4 +Atp transport 0.70621683093252 1.4605854946820496 0.1441292293915674 1.0 0.7815937456234014 6 P12235,P12236,P05141,Q86VD7,Q6NUK1 5 +Semaphorin plexin signaling pathway 0.7149710419117339 1.4586847146824748 0.1446519050444656 1.0 0.7815937456234014 5 P42892 1 +Neutrophil chemotaxis 0.5660336374819781 1.454051561566844 0.145932011480901 1.0 0.7815937456234014 12 Q07021,P35613,O94813,O00429 4 +Dna templated transcription termination 0.7044644332717047 1.4529498756463806 0.1462376715119151 1.0 0.7815937456234014 6 O75844 1 +Regulation of leukocyte mediated immunity 0.5213906214668977 1.4490791038024768 0.1473154928701132 1.0 0.7815937456234014 27 O15400,P46108,P01889,P11279,P02786,P51809,P04439,Q7Z434,Q9NUQ9 9 +Substrate dependent cell migration cell extension 0.7480268112711049 1.4485849944832452 0.1474535142074962 1.0 0.7815937456234014 4 O00560 1 +Long chain fatty acid transport 0.5722406803896523 1.4478677811573686 0.1476540318344097 1.0 0.7815937456234014 11 P23786,O14975 2 +Regulation of peptidase activity 0.4207491867378652 1.4473312528007527 0.1478041699881607 1.0 0.7815937456234014 69 Q92530,Q92542,O95831,Q15375,Q06481,P07858,O14737,P05067,Q15041,Q99538,Q15392,P16435,Q9Y3D6,O43847,Q9NZJ7 15 +Dna methylation involved in gamete generation 0.8239718936129687 1.446637446700951 0.1479984925253663 1.0 0.7815937456234014 3 Q8N2A8 1 +Glycoprotein catabolic process 0.8234283844047827 1.4444435462517746 0.1486142489483364 1.0 0.7815937456234014 3 O00462 1 +Regulation of protein targeting to membrane 0.6762110872021705 1.4435663237385168 0.148861003527766 1.0 0.7815937456234014 7 P27105 1 +Positive regulation of stress activated protein kinase signaling cascade 0.6222629901054033 1.4432615014142551 0.1489468204189015 1.0 0.7815937456234014 9 P05067 1 +Regulation of response to external stimulus 0.4416984660604868 1.4410771320089877 0.1495628932304891 1.0 0.7815937456234014 113 O94813,O43657,Q96PK6,P80303,P05067,Q99538,Q7Z434,Q96G23,Q8N2K0,Q9NZ08,O14786,P14174,P01889,P46108,O00429,Q9UMX5,P04439,Q99735,O75844,Q6P1A2,P04062,Q06481,Q9NUQ9,P53634,P28070,P11279,P51809,Q07021,Q9Y5A9,Q9NUD5 30 +Negative regulation of nitric oxide metabolic process 0.7457493251351204 1.4390329328781646 0.1501411921835462 1.0 0.7815937456234014 4 P30536,P06280 2 +3 utr mediated mrna destabilization 0.7011377298852621 1.4384443491804575 0.1503080168505812 1.0 0.7815937456234014 6 Q14103,Q92945 2 +Regulation of neuronal action potential 0.9269492808478424 1.438095254280748 0.1504070289882837 1.0 0.7815937456234014 2 Q06787 1 +Regulation of transmission of nerve impulse 0.9269492808478424 1.438095254280748 0.1504070289882837 1.0 0.7815937456234014 2 Q06787 1 +Microglia differentiation 0.9269492808478408 1.438095254280741 0.1504070289882857 1.0 0.7815937456234014 2 P05067 1 +Amyloid precursor protein metabolic process 0.525424092133172 1.437457753219372 0.1505879687142315 1.0 0.7815937456234014 17 Q92542,Q9NQX7,O95197,Q15392 4 +Regulation of monooxygenase activity 0.6481589561858008 1.4369004833611394 0.1507462725756889 1.0 0.7815937456234014 8 P06280 1 +Regulation of collateral sprouting 0.8209011737978121 1.43424191958752 0.1515032382770369 1.0 0.7815937456234014 3 Q15375,P53990 2 +Regulation of triglyceride metabolic process 0.9258137774413312 1.4334492570076138 0.1517294903449118 1.0 0.7815937456234014 2 Q8WTV0 1 +Positive regulation of pattern recognition receptor signaling pathway 0.6738044200081936 1.432557957607958 0.1519842038516388 1.0 0.7815937456234014 7 Q9NUD5 1 +Tail anchored membrane protein insertion into er membrane 0.6466008019000371 1.429408774109186 0.1528867780265466 1.0 0.7815937456234014 8 P46379,Q7L5D6,Q9NPA0,O43681 4 +Small rna loading onto risc 0.7433286728927739 1.4288775118708072 0.1530394420153888 1.0 0.7815937456234014 4 Q5KU26 1 +Regulation of blood circulation 0.5173115123371386 1.427910017814418 0.1533177598069237 1.0 0.7815937456234014 20 Q14126,P10253,O75844,P42892 4 +Positive regulation of nf kappab transcription factor activity 0.5177796626985651 1.423216005813151 0.1546735470798526 1.0 0.7815937456234014 24 P02786,O75955,P05067 3 +Decidualization 0.9231642694928064 1.4226104023473096 0.1548491267840774 1.0 0.7815937456234014 2 P07858 1 +Regulation of post translational protein modification 0.8177655420436478 1.4215835465237616 0.1551471840405809 1.0 0.7815937456234014 3 Q32P28 1 +Regulation of alternative mrna splicing via spliceosome 0.5175079682485074 1.4215593516570315 0.1551542121409181 1.0 0.7815937456234014 26 P51114,Q15007,Q92841,Q8IY67,Q9BWF3,P62995,Q01130,P52756,P38159,Q07666,P51116,P17844,Q9Y2W1,P09651,Q9UHX1,Q06787 16 +Collagen fibril organization 0.6712920318256662 1.4210575459128814 0.1553000306683396 1.0 0.7815937456234014 7 P13674,Q92791,O75718 3 +Regulation of mitochondrion organization 0.5072013506415292 1.4206167963352214 0.155428192834506 1.0 0.7815937456234014 39 P12235,Q9H3K2,P11233,Q8N2A8,P02786,P30536,O00429,O14737,Q13501,P21796,Q9NUQ9,Q9Y3D6 12 +Regulation of gene silencing by rna 0.5455092948531098 1.420460478213476 0.1554736666561171 1.0 0.7815937456234014 14 O75844,P51114,Q06787 3 +Adp transport 0.7059492231906057 1.419840180205271 0.1556542143916934 1.0 0.7815937456234014 5 P12235,Q86VD7,P05141,P12236 4 +Lymphocyte mediated immunity 0.5144939625312841 1.418246051816381 0.156118941083553 1.0 0.7815937456234014 32 O15400,P46108,P01889,P11279,P02786,P51809,P04439,Q07021,P53634,Q9UQ84 10 +Presynapse organization 0.7394501211495071 1.412599954530368 0.1577733824383154 1.0 0.7815937456234014 4 P05067 1 +Response to ph 0.7039457309899462 1.4112041651805125 0.1581844223798429 1.0 0.7815937456234014 5 Q99538,P04062 2 +Plasma lipoprotein particle clearance 0.6157194033287802 1.4101065989350765 0.1585082090576155 1.0 0.7815937456234014 9 P38571,Q8WTV0,P09601,Q9H4M9,Q92945 5 +Low density lipoprotein particle clearance 0.6157194033287802 1.4101065989350765 0.1585082090576155 1.0 0.7815937456234014 9 P38571,Q8WTV0,P09601,Q9H4M9,Q92945 5 +Regulation of glucose import 0.6421267395426535 1.4078758876197714 0.1591678241548439 1.0 0.7815937456234014 8 Q06481 1 +Regulation of myelination 0.641495013205676 1.4048329999394713 0.160070943628551 1.0 0.7815937456234014 8 Q96P11,P53634 2 +Neurotransmitter metabolic process 0.8131641814111257 1.403007476067676 0.1606146096040848 1.0 0.7815937456234014 3 P49189 1 +Regulation of nitric oxide metabolic process 0.6137666816114271 1.4001974541139683 0.1614541980316763 1.0 0.7815937456234014 9 P30536,P06280 2 +Regulation of hormone metabolic process 0.7011909159702878 1.3993241833794072 0.1617157908406372 1.0 0.7815937456234014 5 O75844,P16435 2 +Response to zinc ion 0.7011427069961169 1.3991162306266565 0.1617781313196946 1.0 0.7815937456234014 5 P30536,Q8TAD4 2 +Intestinal lipid absorption 0.8115701736321076 1.3965723733274864 0.1625422028326155 1.0 0.7815937456234014 3 Q16739 1 +Eye photoreceptor cell development 0.81105641802349 1.3944983330499086 0.1631671725304055 1.0 0.7815937456234014 3 P54802,Q15555 2 +Regulation of dendritic spine development 0.5555588697774152 1.3936464227022305 0.1634244026455831 1.0 0.7815937456234014 12 Q9UQB8,Q06787 2 +Triglyceride metabolic process 0.6390824063029352 1.3932064351308049 0.1635573743727993 1.0 0.7815937456234014 8 Q96N66,Q8WTV0 2 +Glycolipid biosynthetic process 0.734664864200722 1.392508368372493 0.1637685093298952 1.0 0.7815937456234014 4 Q16739 1 +Cardiac muscle cell membrane repolarization 0.6901858874181299 1.3906000430416412 0.1643467433015648 1.0 0.7815937456234014 6 O75844 1 +Mitochondrial transmembrane transport 0.4928192018737036 1.3902129526765694 0.1644642213748448 1.0 0.7815937456234014 45 Q15388,Q99595,P12235,O95831,Q9H2D1,Q6P4A7,P23786,O60830,O43615,P24539,P21796,Q00325,O43772,O14925,O95563,Q96NB2,Q9Y619,O75964 18 +Cerebellar cortex development 0.5547296059876219 1.388852062039726 0.1648777402121168 1.0 0.7815937456234014 12 P04062,Q5KU26,P54802 3 +Toll like receptor 4 signaling pathway 0.914837244511732 1.3885646618064589 0.1649651693820089 1.0 0.7815937456234014 2 Q06481 1 +Cell adhesion molecule production 0.914837244511732 1.3885646618064589 0.1649651693820089 1.0 0.7815937456234014 2 Q5KU26 1 +Positive regulation of cell adhesion molecule production 0.914837244511732 1.3885646618064589 0.1649651693820089 1.0 0.7815937456234014 2 Q5KU26 1 +Regulation of toll like receptor 4 signaling pathway 0.914837244511732 1.3885646618064589 0.1649651693820089 1.0 0.7815937456234014 2 Q06481 1 +Sodium ion transmembrane transport 0.5174476957359323 1.3869966769159894 0.1654427761409027 1.0 0.7815937456234014 17 P05026,P55011,P27105,Q6P4Q7,Q9Y6M7,P08195 6 +Regulation of immune effector process 0.5040527070057967 1.3869945638666563 0.1654434204751356 1.0 0.7815937456234014 38 P14174,O15400,P46108,P01889,Q06481,P11279,P02786,P51809,P04439,Q07021,Q7Z434,Q9NUQ9 12 +Regulation of skeletal muscle cell differentiation 0.7329545454545492 1.3853252736898591 0.1659530290166575 1.0 0.7815937456234014 4 P17844,Q9BYT8,Q9BRT2 3 +Sodium ion export across plasma membrane 0.8087684274536028 1.3852618685587983 0.1659724088750227 1.0 0.7815937456234014 3 P05026 1 +Quaternary ammonium group transport 0.808674847504661 1.384884100851874 0.1660879093383109 1.0 0.7815937456234014 3 O43772 1 +Regulation of glucose transmembrane transport 0.6104471347918528 1.383336855438946 0.1665616022787506 1.0 0.7815937456234014 9 Q06481 1 +Regulation of synapse assembly 0.66263829550331 1.381381668325795 0.1671616393302946 1.0 0.7815937456234014 7 P05067 1 +Regulation of postsynaptic membrane potential 0.6099459189763784 1.380789423501318 0.1673437164118243 1.0 0.7815937456234014 9 Q9UQB8,P05067 2 +Chemical synaptic transmission postsynaptic 0.6099459189763784 1.380789423501318 0.1673437164118243 1.0 0.7815937456234014 9 Q9UQB8,P05067 2 +Protein lipid complex subunit organization 0.7315916009589863 1.37960039752209 0.167709714990963 1.0 0.7815937456234014 4 Q8WTV0 1 +Positive regulation of immune effector process 0.5088332847113552 1.378273672157735 0.1681188086371283 1.0 0.7815937456234014 32 P14174,O15400,P01889,Q06481,P11279,P02786,P51809,P04439,Q7Z434,Q9NUQ9 10 +Intestinal absorption 0.6865473650587995 1.3746757829360654 0.1692319823521715 1.0 0.7815937456234014 6 Q16739,Q8WTV0 2 +Regulation of synapse structure or activity 0.5096489276333928 1.372827922728321 0.1698058479972883 1.0 0.7815937456234014 29 Q15375,Q9UQB8,P50897,O00264,P05067 5 +Glycoprotein biosynthetic process 0.5053260521681937 1.3711310886081909 0.1703340952114576 1.0 0.7815937456234014 35 Q10472,Q9NQX7,Q8NCH0,Q10471,Q8N6G5,Q9Y5P6,Q9BV10,O15118,O60502,Q92542,Q9BT22,P46977,O43505 13 +Mitochondrial fission 0.5838167347661676 1.370583598966284 0.1705047985644905 1.0 0.7815937456234014 10 Q9Y3D6,P11233,O00429 3 +Negative regulation of synapse organization 0.9102952308856916 1.3700089022944402 0.170684122726068 1.0 0.7815937456234014 2 Q15375 1 +Autophagy of mitochondrion 0.5095084557267088 1.369631695869368 0.1708019002448648 1.0 0.7815937456234014 28 P12235,P04062,P30536,O00429,Q13501,P21796,Q9Y3D6,O95140 8 +Cardiac septum morphogenesis 0.7290158760227875 1.3687798271110236 0.1710681085064185 1.0 0.7815937456234014 4 O14786,O94813 2 +Modification of synaptic structure 0.6339939496857535 1.3686565245971982 0.1711066661641065 1.0 0.7815937456234014 8 Q9UQB8,O00264 2 +Protein trimerization 0.7286524132862247 1.3672527740981688 0.1715460887758417 1.0 0.7815937456234014 4 Q99720,P14174 2 +Humoral immune response mediated by circulating immunoglobulin 0.9095382286146853 1.366917426488408 0.171651189109298 1.0 0.7815937456234014 2 Q9UQ84 1 +Transepithelial transport 0.6921396393332275 1.3602502592828554 0.1737507429253502 1.0 0.7815937456234014 5 P51798,P08183,P78310 3 +Amino acid betaine transport 0.9076457229371688 1.3591902744470663 0.1740863023173826 1.0 0.7815937456234014 2 O43772 1 +Zymogen activation 0.65776448650091 1.3589949846561633 0.1741481779734193 1.0 0.7815937456234014 7 Q99538 1 +Positive regulation of leukocyte degranulation 0.7263410930460548 1.3575411852848076 0.1746093164085629 1.0 0.7815937456234014 4 P11279 1 +Negative regulation of cell development 0.505640600726854 1.3556743977388483 0.1752027888399767 1.0 0.7815937456234014 19 P30536,Q15375,Q96G23,Q06481 4 +Nik nf kappab signaling 0.5061640976314973 1.3550758734462474 0.1753933846283071 1.0 0.7815937456234014 20 O43657 1 +Regulation of ire1 mediated unfolded protein response 0.6905790353634147 1.3535073884251343 0.1758935912716925 1.0 0.7815937456234014 5 P18031,P57088 2 +Modulation by host of viral process 0.5483628323791113 1.3519855838444117 0.1763799270724522 1.0 0.7815937456234014 12 P11717,P27105 2 +L glutamate transmembrane transport 0.6813319462982005 1.3518267496535648 0.1764307447531679 1.0 0.7815937456234014 6 O75915,Q15041,O60831 3 +Endocrine process 0.7243522951675895 1.3491837459063456 0.1772779542529727 1.0 0.7815937456234014 4 P42892 1 +Triglyceride biosynthetic process 0.6892989752173735 1.3479754827891546 0.1776662682861245 1.0 0.7815937456234014 5 Q9HCL2,Q8WTV0 2 +Positive regulation of cold induced thermogenesis 0.5475285055575098 1.347147120359593 0.1779328547718905 1.0 0.7815937456234014 12 P23786,O95140,Q06481,Q16836 4 +Regulation of heterotypic cell cell adhesion 0.9042392127176382 1.3452872418055213 0.1785324920201692 1.0 0.7815937456234014 2 O75955 1 +Regulation of toll like receptor 3 signaling pathway 0.9042392127176382 1.3452872418055213 0.1785324920201692 1.0 0.7815937456234014 2 O75955 1 +Regulation of myoblast differentiation 0.9042392127176356 1.345287241805511 0.1785324920201725 1.0 0.7815937456234014 2 Q9NWT6 1 +Alcohol biosynthetic process 0.5025098182115678 1.3441519583787036 0.178899253201191 1.0 0.7815937456234014 34 Q13510,P04062,O15269,O75845,O75477,P35270,Q16850,Q14739,Q15392,Q9H2C2,Q6P1A2,P16435,P48449,Q9UBM7 14 +Interferon gamma production 0.6785304112369657 1.3395422655866571 0.1803942046573274 1.0 0.7815937456234014 6 P04439,Q07021 2 +Receptor metabolic process 0.5049682823203053 1.3370628646421825 0.1812021175344909 1.0 0.7815937456234014 27 P02786,O00560,Q99538,P42892,Q06787 5 +Regulation of receptor internalization 0.6009956628659242 1.3352291518280035 0.1818013584601687 1.0 0.7815937456234014 9 O00560,Q06787 2 +Glycosyl compound catabolic process 0.600880786853628 1.3346435480253236 0.1819930379370169 1.0 0.7815937456234014 9 P04062,P08236,P06280,P04066,Q9BTY2,Q9NUJ1 6 +Positive regulation of mitophagy 0.796111960569839 1.334181515657972 0.1821443758543348 1.0 0.7815937456234014 3 P21796 1 +Mannosylation 0.6772641120861831 1.3339872831404869 0.1822080242450501 1.0 0.7815937456234014 6 Q9BV10,O43505 2 +Interleukin 6 production 0.5448865448440396 1.3318148541346937 0.1829210356020192 1.0 0.7815937456234014 12 P01889,P05067 2 +Negative regulation of rna catabolic process 0.5037166818901375 1.331668783682722 0.1829690513752067 1.0 0.7815937456234014 29 Q14103,O60506,Q14011,Q13151,Q99729,P07910,P35637,Q92804,Q06787 9 +Cellular response to dsrna 0.626118915253306 1.330590885447697 0.1833236631900425 1.0 0.7815937456234014 8 O75955,Q5KU26,Q9NUD5 3 +Regulation of t cell proliferation 0.5303819055733219 1.3297093358425085 0.1836140576738762 1.0 0.7815937456234014 14 P02786,Q9HCL2,P04439 3 +Metal ion homeostasis 0.4137712628080976 1.3287288401201622 0.1839374464591738 1.0 0.7815937456234014 68 O43819,P05067,Q9UJZ1,O76024,P55011,P51572,P61421,P16615,Q9Y3D6,P35670,Q9BXP2,P05026,P62942,P30519,P09601,Q6P4Q7,Q8TAD4,Q96A33,Q9Y487,P02786,P05023,Q8N511,Q9HD20,P07686,P04899,Q15904 26 +Regulation of adaptive immune response 0.5080204791456986 1.327086402176332 0.1844801028794243 1.0 0.7815937456234014 17 P02786,O15400,P01889,P04439 4 +Cerebellar purkinje cell layer development 0.6751496392600254 1.3247083537017617 0.1852679013894227 1.0 0.7815937456234014 6 P04062,P54802 2 +Digestion 0.5988603435719089 1.3243405866372469 0.1853899568915145 1.0 0.7815937456234014 9 Q16739,Q8WTV0 2 +Regulation of amino acid transport 0.7177130389893794 1.321278791087565 0.1864084230492584 1.0 0.7815937456234014 4 P55011,Q15041 2 +Amine transport 0.7177130389893794 1.321278791087565 0.1864084230492584 1.0 0.7815937456234014 4 P55011,Q15041 2 +Response to nerve growth factor 0.5430178264893686 1.3209601635131338 0.1865146473875143 1.0 0.7815937456234014 12 Q99523,P46108,P05067 3 +Cell cell adhesion mediated by cadherin 0.7169791538200614 1.318193910568015 0.1874387434790372 1.0 0.7815937456234014 4 O75955,Q07157 2 +Phosphatidylserine metabolic process 0.6823824766978465 1.3180682149532217 0.1874808135728378 1.0 0.7815937456234014 5 Q8N2K0,Q8NCC3,Q6P1A2 3 +Very long chain fatty acid catabolic process 0.7163651669059776 1.3156129873269709 0.1883039722642072 1.0 0.7815937456234014 4 Q15067 1 +Cellular carbohydrate metabolic process 0.4646842499577883 1.3153130731296665 0.1884047062847191 1.0 0.7815937456234014 53 P10253,P16278,P08236,O75844,Q14108,Q9NUJ1,P48735,O43505 8 +Neural precursor cell proliferation 0.5000629452880824 1.3150280039025175 0.1885004910772172 1.0 0.7815937456234014 20 Q06481,O75306,O95456,P04899,Q9H0H5,P55209 6 +Response to mitochondrial depolarisation 0.6473823652533798 1.3112171130319132 0.1897844223076388 1.0 0.7815937456234014 7 Q13501,P04062,O95140 3 +Cellular response to oxygen levels 0.4986323946494007 1.310649978649621 0.189976045625263 1.0 0.7815937456234014 33 O95831,Q9NWT6,Q9Y487,O75306,Q8N511,P55786,Q9Y4P3,Q99808,P61421,Q96A26,Q15904 11 +Phagocytosis 0.4995952869162829 1.308737816508826 0.1906231771742765 1.0 0.7815937456234014 31 Q06481,Q8WTV0,P51790,P51809,Q5KU26,Q92544 6 +Alanine transport 0.8951551854655566 1.3082539043511947 0.1907872042227056 1.0 0.7815937456234014 2 Q96QD8 1 +Branched chain amino acid transport 0.8951551854655543 1.3082539043511865 0.1907872042227085 1.0 0.7815937456234014 2 Q96H78 1 +Neutrophil migration 0.5337364406648859 1.3074301273888764 0.1910666709144626 1.0 0.7815937456234014 13 Q07021,P35613,O94813,O00429 4 +Middle ear morphogenesis 0.7143084969152447 1.3069675041060271 0.1912237481076195 1.0 0.7815937456234014 4 P54802 1 +Positive regulation of release of cytochrome c from mitochondria 0.6795656440007701 1.305880680991336 0.1915931373233219 1.0 0.7815937456234014 5 O00429,O14737 2 +Digestive system process 0.6209454805077926 1.30553992360186 0.19170906189208 1.0 0.7815937456234014 8 Q16739,Q8WTV0 2 +Import into cell 0.4988838399179821 1.3036053238994294 0.1923681845229108 1.0 0.7815937456234014 21 P05026,O75955,Q99816,O14975,P55011,P05023,Q15041,Q15758,Q99808,P08195,Q9BXP2 11 +Isocitrate metabolic process 0.6786337386131787 1.3018477784121802 0.1929684271840432 1.0 0.7815937456234014 5 P48735 1 +Positive regulation of filopodium assembly 0.6699267554237471 1.3017724721005666 0.1929941767506786 1.0 0.7815937456234014 6 P11233,Q06787 2 +Peroxisome organization 0.6195572566358625 1.2988122445049093 0.1940083714996343 1.0 0.7815937456234014 8 P28288,Q9Y3D6,Q7Z434,O00429 4 +Phospholipid homeostasis 0.8925056775170327 1.297465261252433 0.1944711503668643 1.0 0.7815937456234014 2 Q96CP7 1 +Diacylglycerol biosynthetic process 0.8925056775170304 1.2974652612524236 0.1944711503668676 1.0 0.7815937456234014 2 Q8NCC3 1 +Diacylglycerol metabolic process 0.8925056775170304 1.2974652612524236 0.1944711503668676 1.0 0.7815937456234014 2 Q8NCC3 1 +T cell proliferation 0.4969273271929051 1.294397506585848 0.1955281514725189 1.0 0.7815937456234014 20 P04439,Q92542,P02786,Q9HCL2 4 +Vacuolar proton transporting v type atpase complex assembly 0.8917486752460237 1.2943839477494672 0.195532832527165 1.0 0.7815937456234014 2 Q8N511 1 +Proton transporting v type atpase complex assembly 0.8917486752460237 1.2943839477494672 0.195532832527165 1.0 0.7815937456234014 2 Q8N511 1 +Peripheral nervous system axon regeneration 0.7111003527917639 1.2934814033316804 0.1958446118662919 1.0 0.7815937456234014 4 P30536,Q96G23 2 +Golgi to endosome transport 0.6435201647914794 1.293414849492719 0.1958676169643984 1.0 0.7815937456234014 7 Q8N2H4 1 +Maternal process involved in female pregnancy 0.6183294579559754 1.292860131880761 0.1960594385211662 1.0 0.7815937456234014 8 Q9BQE5,P07858 2 +Golgi to lysosome transport 0.7107936608912777 1.292192162207317 0.1962906053177047 1.0 0.7815937456234014 4 Q99523 1 +Regulation of autophagy of mitochondrion 0.5448340475052689 1.2919269486958505 0.1963824441214559 1.0 0.7815937456234014 11 P30536,P21796,O00429 3 +Regulation of retinal ganglion cell axon guidance 0.8909916729750172 1.291303162968383 0.1965985742894749 1.0 0.7815937456234014 2 O94813 1 +Neuron projection extension involved in neuron projection guidance 0.8909916729750172 1.291303162968383 0.1965985742894749 1.0 0.7815937456234014 2 O94813 1 +Axonogenesis involved in innervation 0.890991672975016 1.2913031629683789 0.1965985742894764 1.0 0.7815937456234014 2 P42892 1 +Semaphorin plexin signaling pathway involved in neuron projection guidance 0.890991672975016 1.2913031629683789 0.1965985742894764 1.0 0.7815937456234014 2 P42892 1 +Innervation 0.890991672975016 1.2913031629683789 0.1965985742894764 1.0 0.7815937456234014 2 P42892 1 +Regulation of organic acid transport 0.5922522355329081 1.2906008745173907 0.1968421126144384 1.0 0.7815937456234014 9 Q9Y3D6,P14174,Q15041 3 +Photoreceptor cell differentiation 0.6758557618498124 1.2898235280010213 0.1971119369450591 1.0 0.7821662966347599 5 P54802,Q15555 2 +Regulation of neuron projection development 0.4430880270311538 1.283843456464668 0.1991967348800134 1.0 0.7874278548336278 59 O14786,Q9NQX7,Q13308,Q15375,O94813,P46108,Q9UL15,Q9H4M9,Q9UQB8,Q32P28,P53990,Q14012,Q9NR77,Q96G23,P07196,Q14108,Q7L576 17 +Response to dsrna 0.5226764880957108 1.2832495529980623 0.1994046603366663 1.0 0.787749628969597 14 O75955,Q5KU26,P08195,Q9NUD5 4 +Pyramidal neuron differentiation 0.7825094866314526 1.2793345189369614 0.2007792818717524 1.0 0.789453949209749 3 P04062 1 +Photoreceptor cell development 0.7069516901409467 1.2760420468541978 0.2019406560431056 1.0 0.7898152936565719 4 P54802,Q15555 2 +Intracellular distribution of mitochondria 0.8868281604844788 1.274368667924783 0.202532790978875 1.0 0.7905762737520224 2 O75153 1 +Myeloid leukocyte activation 0.5066708431724453 1.2722591868141775 0.2032810445062018 1.0 0.7925264073572336 16 P14174,P09601,P51809,P05067,P53634 5 +T cell migration 0.6386845367320921 1.2711059448849675 0.2036909606992178 1.0 0.7926607598752817 7 P46108,P05067 2 +Positive regulation of cell cell adhesion mediated by cadherin 0.7800337859828287 1.2693610980476293 0.204312304270692 1.0 0.7933745334548803 3 O75955 1 +Regulation of cell cell adhesion mediated by cadherin 0.7800337859828287 1.2693610980476293 0.204312304270692 1.0 0.7933745334548803 3 O75955 1 +Positive regulation of insulin secretion involved in cellular response to glucose stimulus 0.705240494363931 1.2688492592863685 0.2044948324070183 1.0 0.7933745334548803 4 O95563 1 +Regulation of transmembrane transport 0.4275933108033773 1.2687676334537077 0.2045239521675366 1.0 0.7933745334548803 63 P05026,Q06481,P27105,P05067,Q16625,P21796,O75844,P08183,Q8TAD4,Q96GC9,Q06787 11 +Negative regulation of mrna metabolic process 0.4880002899265365 1.2674841226273952 0.2049822372783327 1.0 0.7939428444475759 38 Q14103,P35637,O60506,Q14011,Q13151,P38159,Q99729,Q07021,P07910,P26368,P22626,Q92804,Q06787 13 +Regulation of endocytosis 0.4898060388868887 1.264961563950885 0.2058851064635867 1.0 0.7939428444475759 36 Q06481,O00560,P50897,P05067,Q06787 5 +Regulation of tor signaling 0.5638773351253019 1.2631215403508147 0.2065455039365744 1.0 0.7939428444475759 10 O75844 1 +Regulation of regulated secretory pathway 0.497922260691564 1.2626080167390266 0.2067300854069411 1.0 0.7939428444475759 17 Q06787,P11279,P09601,P51809,P16615,P04899,O00186 7 +Estrogen metabolic process 0.6694767460288451 1.2622010368063872 0.2068764557396436 1.0 0.7939428444475759 5 O95470,Q8NBQ5 2 +L methionine salvage from methylthioadenosine 0.8834216502649508 1.26052622952146 0.207479591910026 1.0 0.7939428444475759 2 Q13126 1 +Amino acid salvage 0.8834216502649508 1.26052622952146 0.207479591910026 1.0 0.7939428444475759 2 Q13126 1 +Sodium ion transport 0.4923468679957927 1.2602739849924496 0.2075705413187625 1.0 0.7939428444475759 21 P05026,P55011,P27105,Q6P4Q7,Q9Y6M7,Q96QD8,P08195 7 +Sulfate transport 0.7777357061719088 1.2601062923039823 0.2076310206772178 1.0 0.7939428444475759 3 Q9UBX3,Q9H0H5 2 +Phosphate ion transport 0.7777357061719058 1.2601062923039703 0.2076310206772222 1.0 0.7939428444475759 3 Q00325,Q9UBX3 2 +Phosphate ion transmembrane transport 0.7777357061719058 1.2601062923039703 0.2076310206772222 1.0 0.7939428444475759 3 Q00325,Q9UBX3 2 +Regulation of endoplasmic reticulum tubular network organization 0.7765997728133259 1.2555328335187994 0.2092853966676449 1.0 0.7939428444475759 3 P57088,Q15041 2 +Positive regulation of amine transport 0.7764842967344379 1.255067952041936 0.2094540932278132 1.0 0.7939428444475759 3 Q15041 1 +Positive regulation of amino acid transport 0.7764842967344379 1.255067952041936 0.2094540932278132 1.0 0.7939428444475759 3 Q15041 1 +Sulfur compound transport 0.635008607362539 1.2541336475202056 0.2097934321947616 1.0 0.7939428444475759 7 Q70HW3,Q8TB61,Q9UBX3 3 +Positive regulation of mitochondrial fission 0.6348359015809654 1.2533359681158696 0.2100834638131967 1.0 0.7939428444475759 7 Q9Y3D6,P11233 2 +Ire1 mediated unfolded protein response 0.6589009025244206 1.253285163706154 0.2101019458285531 1.0 0.7939428444475759 6 P18031,P57088 2 +Xenobiotic export 0.881529144587434 1.2528413768281568 0.2102634400425005 1.0 0.7939428444475759 2 P08183 1 +Xenobiotic transport 0.881529144587434 1.2528413768281568 0.2102634400425005 1.0 0.7939428444475759 2 P08183 1 +Bone growth 0.774931249144729 1.2488165451770423 0.2117321810374137 1.0 0.7939428444475759 3 O75844 1 +Growth plate cartilage development 0.774931249144729 1.2488165451770423 0.2117321810374137 1.0 0.7939428444475759 3 O75844 1 +Ovulation cycle process 0.8803936411809217 1.2482323878724078 0.2119459663474561 1.0 0.7939428444475759 2 O94813 1 +Regulation of leukocyte degranulation 0.665420789288546 1.244631243526568 0.2132673302725027 1.0 0.7939428444475759 5 P11279,P51809 2 +Negative regulation of response to external stimulus 0.4760948372648459 1.2433550696100752 0.2137370193556231 1.0 0.7939428444475759 44 O14786,P14174,P04062,O94813,P01889,P46108,O43657,P80303,Q9UMX5,P04439,Q07021,Q9Y5A9,Q96G23,Q6P1A2,P28070 15 +Regulation of gtp binding 0.6651085954489611 1.243278697405945 0.21376515139226 1.0 0.7939428444475759 5 O75503 1 +Negative regulation of growth 0.4912695960129861 1.2428458806361338 0.2139246318190195 1.0 0.7939428444475759 27 Q99538,P50897,Q15375 3 +Ion transmembrane transport 0.4484837569768732 1.2421278417877115 0.2141893975849371 1.0 0.7939428444475759 137 P12235,Q8TB61,Q9UDW1,P05067,P53985,Q96ES6,P21796,Q9UBX3,Q9C0H2,P08195,Q9Y619,P08183,Q06787,P45880,P51798,P55011,P27105,P51790,Q15041,Q00325,O75844,P61421,P16615,P35670,Q96GC9,O75964,P05026,P62942,Q9H2D1,Q9UHG3,Q6P4A7,O60831,P24539,Q15758,Q6P4Q7,O43772,Q70HW3,Q8TAD4,Q96NB2,Q9Y277,P12236,Q13423,Q9HD20,Q9Y6M7,O95563 45 +Memory 0.6561356129921141 1.2411119269702455 0.2145644041323371 1.0 0.7939428444475759 6 Q99538 1 +Negative regulation of defense response to virus 0.6642851205144094 1.2397109800706922 0.215082314425578 1.0 0.7939428444475759 5 O43657 1 +Protein quality control for misfolded or incompletely synthesized proteins 0.5356188674586966 1.2391283812582157 0.2152979579918945 1.0 0.7939428444475759 11 Q16740,Q9BUN8 2 +Polyol biosynthetic process 0.528939382473982 1.2389384921841111 0.2153682773271834 1.0 0.7939428444475759 12 Q13510,P04062,O15269,P35270 4 +Myeloid leukocyte migration 0.4891334419992297 1.238923999336617 0.2153736449685233 1.0 0.7939428444475759 21 O94813,P35613,O00429,P78310,Q99538,Q07021 6 +Amide transport 0.4895892724063787 1.237886010175807 0.2157583303521026 1.0 0.7939428444475759 31 Q9H2D1,Q16836,Q9Y5P4,P22059,O95563,P00367,P07602,P53985,P40939,P08183,Q9BRT2,Q9NZJ7,O00186 13 +Extracellular exosome assembly 0.697813715786541 1.2376373904258768 0.2158505438258422 1.0 0.7939428444475759 4 O00560 1 +Blastoderm segmentation 0.6974001656313823 1.2358997689354725 0.2164958229357068 1.0 0.7942797075660221 4 Q8N2A8 1 +Protein targeting to vacuole 0.5349319982802616 1.235186601069642 0.2167610647737365 1.0 0.7942797075660221 11 Q99523,Q14108 2 +Positive regulation of cysteine type endopeptidase activity 0.4884212302639636 1.2341878269061184 0.217132922416956 1.0 0.7942829465146699 21 O75915,O95831,Q9Y3D6,P51572,O14737,Q99538,Q9NR28,Q96A26,Q9NZJ7 9 +Metal ion export 0.6302980703827581 1.2323688104280448 0.2178113462742592 1.0 0.7944289272175213 7 P05026,P05023,P35670 3 +Cholesterol storage 0.8762301286903833 1.2313456423313252 0.2181936179797561 1.0 0.7944289272175213 2 Q8WTV0 1 +Positive regulation of cholesterol storage 0.8762301286903833 1.2313456423313252 0.2181936179797561 1.0 0.7944289272175213 2 Q8WTV0 1 +Interleukin 12 production 0.6621073942032811 1.2302753113422449 0.2185940262379939 1.0 0.7949240912856882 5 P01889 1 +Negative regulation of macroautophagy 0.6052812357825348 1.229504346996948 0.2188827690279995 1.0 0.7949240912856882 8 O15118 1 +Cellular response to inorganic substance 0.487298623603873 1.2291797974661018 0.2190044017278039 1.0 0.7949240912856882 33 O95831,Q14103,P46108,P30536,P55011,P05198,P05067,Q99538,Q92542,Q06787 10 +Protein insertion into membrane 0.4887968546482277 1.228264323423307 0.2193477590720887 1.0 0.7949240912856882 24 Q7L5D6,Q9NS69,O43681,Q9NPA0,O14737,Q9Y276,Q15070,Q15629,Q96A33,P46379 10 +Establishment of protein localization to vacuole 0.5267958011501876 1.2264146327210557 0.2200426822738845 1.0 0.7960405228571791 12 Q99523,Q14108 2 +L serine transport 0.7688728977161908 1.224445965520368 0.2207840383646926 1.0 0.7977953702023078 3 Q96QD8 1 +Positive regulation of response to external stimulus 0.4591471245966775 1.2239685735397796 0.220964083009775 1.0 0.7979828195004983 51 O14786,P11279,O94813,Q96PK6,O00429,P05067,P51809,Q99538,Q7Z434,Q99735,Q07021,P53634,Q9NUD5 13 +Regulation of granulocyte chemotaxis 0.6283983979330947 1.2235868966733092 0.2211081051485488 1.0 0.7980400363216609 7 Q07021,O94813 2 +Glycosyl compound metabolic process 0.4882552542850173 1.2222044609618183 0.2216303173371476 1.0 0.7981655958996067 26 P04062,P08236,P06280,O60725,P04066,Q9BTY2,Q9NUJ1 7 +Cellular response to manganese ion 0.8739591218773621 1.222143606987664 0.2216533250865735 1.0 0.7981655958996067 2 P05067 1 +Biological process involved in symbiotic interaction 0.4075763501704248 1.221523937758419 0.2218877078701371 1.0 0.7981655958996067 67 P11717,P11279,P07858,Q8WTV0,P02786,P27105,O15118,Q9BTY2,Q14108,Q06787 10 +Sodium ion homeostasis 0.6514810419469983 1.2206121593671226 0.2222329003048482 1.0 0.7983970209451732 6 P05026,P55011,P04899 3 +Cell volume homeostasis 0.6919396679290816 1.2129613811912154 0.2251445859188141 1.0 0.8031105150747694 4 P55011,P51790 2 +Regulation of protein exit from endoplasmic reticulum 0.7644831503218438 1.2068051271436695 0.2275072010662113 1.0 0.8079727662839812 3 P51572,Q92544 2 +Positive regulation of protein exit from endoplasmic reticulum 0.7644831503218438 1.2068051271436695 0.2275072010662113 1.0 0.8079727662839812 3 P51572,Q92544 2 +Developmental maturation 0.4793928279816242 1.202940003222536 0.2289995386268715 1.0 0.8100858678925579 38 O75503,Q8N2A8,O75787,P51790,P05067 5 +Dermatan sulfate proteoglycan metabolic process 0.8690386071158206 1.2022288879144978 0.229274859870987 1.0 0.8103038246299507 2 Q8NCH0 1 +Adenylate cyclase inhibiting g protein coupled receptor signaling pathway 0.5995559414273633 1.2016541772773517 0.2294975416169506 1.0 0.8104660772020051 8 P04899,P07602 2 +Modification of postsynaptic structure 0.6460268386159652 1.1965773985258323 0.2314713142185662 1.0 0.8151246619484127 6 Q9UQB8 1 +Response to chemokine 0.761832639151852 1.1961616331823597 0.2316334898129466 1.0 0.8152346566282678 3 P55011,O94813 2 +Axon development 0.4128101144717348 1.1957402547174472 0.2317979372054692 1.0 0.8153525181024021 65 O75955,Q15375,O94813,Q06481,Q9UQB8,P30536,P35613,P05067,Q96G23,P42892 10 +Negative regulation of viral induced cytoplasmic pattern recognition receptor signaling pathway 0.6877200584662544 1.1952436218872105 0.2319918598122607 1.0 0.8155738674145316 4 O43657 1 +Estrogen biosynthetic process 0.8671461014383022 1.1945781971637082 0.2322518719030943 1.0 0.8159352251024498 2 Q8NBQ5 1 +Adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 0.4840971124932967 1.1935823030866943 0.2326413999018755 1.0 0.8159352251024498 28 O15400,P01889,P02786,P04439,Q07021,P53634,Q9UQ84 7 +Negative regulation of endoplasmic reticulum calcium ion concentration 0.7608199772195142 1.1920968383342738 0.2332232765802051 1.0 0.8159352251024498 3 Q9Y3D6 1 +Regulation of system process 0.4577051070406892 1.191932167063299 0.2332878440389985 1.0 0.8159352251024498 50 P05026,Q14126,P04062,P10253,Q9UQB8,P05067,O75844,P53634,P42892,Q06787 10 +Oligosaccharide lipid intermediate biosynthetic process 0.7606967057932649 1.1916020961457228 0.2334173027160895 1.0 0.8159352251024498 3 Q9BV10,Q9BT22 2 +Immune response regulating signaling pathway 0.4659590489264816 1.1913549893234034 0.2335142549876543 1.0 0.8159352251024498 46 O75955,Q06481,O43657,P04439,Q07021,Q9NUD5,Q5KU26,Q9NPR9,Q14254 9 +Golgi to vacuole transport 0.6525392070714526 1.18881188015214 0.2345137020249392 1.0 0.8159352251024498 5 Q99523 1 +Rna stabilization 0.482828761215843 1.186003910943592 0.2356207550444096 1.0 0.8159352251024498 25 Q14103,O60506,Q14011,Q13151,P07910,P35637,Q92804 7 +Copper ion transport 0.7592489780585833 1.1857928184495647 0.2357041282998828 1.0 0.8159352251024498 3 P35670 1 +Import across plasma membrane 0.5065737149776521 1.1857116401639656 0.2357361960952033 1.0 0.8159352251024498 14 P05026,P55011,P05023,Q15758,Q15041,P08195,Q9BXP2 7 +Regulation of vascular permeability 0.6518109130979715 1.1856557373817065 0.2357582811227754 1.0 0.8159352251024498 5 Q16625 1 +Positive regulation of t cell proliferation 0.571658868679327 1.1850926652736646 0.235980810773027 1.0 0.8159352251024498 9 P02786,P04439 2 +Relaxation of muscle 0.7590562396218066 1.1850195726831465 0.2360097083180901 1.0 0.8159352251024498 3 P05026 1 +Proton transporting two sector atpase complex assembly 0.6852751809152514 1.1849816716042076 0.236024693697052 1.0 0.8159352251024498 4 Q8N511 1 +Fibroblast proliferation 0.5129686498011372 1.183999207818463 0.2364133764036269 1.0 0.8159352251024498 13 P50402,O75844 2 +Retinal rod cell development 0.8644965934897773 1.1838758829405347 0.2364621981945847 1.0 0.8159352251024498 2 P54802 1 +Camera type eye photoreceptor cell differentiation 0.8644965934897773 1.1838758829405347 0.2364621981945847 1.0 0.8159352251024498 2 P54802 1 +Retinal rod cell differentiation 0.8644965934897773 1.1838758829405347 0.2364621981945847 1.0 0.8159352251024498 2 P54802 1 +Photoreceptor cell maintenance 0.8644965934897769 1.1838758829405325 0.2364621981945855 1.0 0.8159352251024498 2 P51790 1 +Urogenital system development 0.4785459430472603 1.1818262005449716 0.2372746694656453 1.0 0.8170752721753916 36 O14786,Q13308,Q15375,O94813,P07602,Q9NZJ7,O75844,O00592,P46379,O95470 10 +Negative regulation of lipase activity 0.7572864692569258 1.177921171067136 0.2388280340396178 1.0 0.8212352796089915 3 Q99523 1 +Embryonic brain development 0.6493957301945635 1.17518950809932 0.2399189068319569 1.0 0.8220951498995326 5 P62995,O60508 2 +Osteoclast differentiation 0.5940515601747709 1.174854728774742 0.2400528401087938 1.0 0.8220951498995326 8 P02786 1 +Positive regulation of endothelial cell proliferation 0.5691742972935234 1.1723325570601288 0.2410635652652555 1.0 0.822817315276977 9 P09601,O14786,O75340,Q9H2J4 4 +Taxis 0.4371122915791154 1.1716813964731887 0.2413249947959972 1.0 0.822817315276977 57 O14786,P14174,Q15375,O94813,P46108,P11233,O00429,P35613,O00264,P05067,P78310,Q99538,Q07021,Q9NUQ9,P42892,Q7L576 16 +Regulation of stress activated protein kinase signaling cascade 0.4795700600851876 1.171378980756569 0.2414464772417885 1.0 0.822817315276977 22 O75844,P05067 2 +Regulation of immune response 0.4121507136259023 1.1708586639141514 0.2416555927859109 1.0 0.822817315276977 108 O15400,O43657,Q96PK6,Q07666,Q8TCT8,O00115,Q9NZ08,P01889,P46108,P04439,P46379,Q9NPR9,Q06481,Q9NUQ9,P28070,Q5KU26,O75955,P11279,P02786,P51809,Q07021,Q9Y5A9,Q9NUD5,Q14254 24 +Apoptotic process involved in development 0.681862026673131 1.170661045601709 0.2417350490540912 1.0 0.822817315276977 4 O94813 1 +Activated t cell proliferation 0.6483427615761498 1.1706266219185388 0.2417488916423602 1.0 0.822817315276977 5 Q9HCL2 1 +Eye morphogenesis 0.5687163899893484 1.1699802775591897 0.2420089057779826 1.0 0.822817315276977 9 O95140,P54802,Q15555 3 +Regulation of cartilage development 0.6811546383025224 1.1676939192448277 0.2429302504664556 1.0 0.822817315276977 4 Q92896 1 +Regulation of chondrocyte differentiation 0.6811546383025224 1.1676939192448277 0.2429302504664556 1.0 0.822817315276977 4 Q92896 1 +Rna interference 0.6162718663529673 1.1674765449598388 0.243017975007906 1.0 0.822817315276977 7 Q5KU26 1 +Alternative mrna splicing via spliceosome 0.4763488262449757 1.165548520559227 0.2437970319111253 1.0 0.822817315276977 36 Q06787,P51114,Q15007,Q92841,Q8IY67,Q9BWF3,P62995,Q01130,P52756,P38159,Q07666,Q07955,P51116,P17844,Q9Y2W1,P09651,Q9UHX1,O60828 18 +Nucleobase transport 0.753502461188948 1.1627547169700976 0.2449290344562718 1.0 0.822817315276977 3 P12235,Q9Y277 2 +Mitochondrial adp transmembrane transport 0.7535024611889469 1.1627547169700927 0.2449290344562738 1.0 0.822817315276977 3 P12235,P12236 2 +Receptor internalization 0.4748612334226799 1.159448536891286 0.2462734021416392 1.0 0.822817315276977 18 P02786,O00560,Q06787 3 +Inner ear receptor cell development 0.6143612286226356 1.158629326282854 0.2466073097184129 1.0 0.822817315276977 7 P54802 1 +2 oxoglutarate metabolic process 0.6141441860516947 1.157624220756555 0.2470174206410895 1.0 0.822852671264991 7 P48735 1 +Regulation of water loss via skin 0.678424886259083 1.156247093174462 0.2475801021494574 1.0 0.822852671264991 4 Q16739 1 +Glycosylation 0.4779883080495959 1.155294816486896 0.2479697179165081 1.0 0.822852671264991 31 Q10472,P04062,O75503,Q10471,Q9Y5P6,Q9BV10,O15118,O60502,Q9BT22,P46977,O43505 11 +Positive regulation of toll like receptor signaling pathway 0.6778010750872944 1.153631946707902 0.2486510950913518 1.0 0.822852671264991 4 O75955 1 +Cellular response to follicle stimulating hormone stimulus 0.75055393955866 1.1509478424525597 0.2497536937457671 1.0 0.822852671264991 3 P16435 1 +Cellular response to gonadotropin stimulus 0.75055393955866 1.1509478424525597 0.2497536937457671 1.0 0.822852671264991 3 P16435 1 +Response to follicle stimulating hormone 0.75055393955866 1.1509478424525597 0.2497536937457671 1.0 0.822852671264991 3 P16435 1 +Response to gonadotropin 0.75055393955866 1.1509478424525597 0.2497536937457671 1.0 0.822852671264991 3 P16435 1 +Prostate gland growth 0.8561695685087015 1.150310277055399 0.250016099475268 1.0 0.822852671264991 2 P07602 1 +Organ growth 0.5007145269003043 1.1500909528704717 0.2501064122438663 1.0 0.822852671264991 14 P10644,P07602,O75844,P16435,Q99956 5 +Regulation of er to golgi vesicle mediated transport 0.6431116124855839 1.1479607769851292 0.2509847562464102 1.0 0.822852671264991 5 Q9P2W9,Q9HCU5 2 +Negative regulation of developmental growth 0.5639333776844561 1.145399795608406 0.252043582968589 1.0 0.822852671264991 9 Q99538,Q15375 2 +Regulation of membrane lipid distribution 0.642358189794929 1.144696775061001 0.2523347878226776 1.0 0.822852671264991 5 Q96CP7,Q9H2C2,Q96GC9 3 +Positive regulation of neuron projection development 0.4762420786473055 1.1429638093862304 0.253053617398326 1.0 0.822852671264991 24 Q9UQB8,Q9H4M9,Q32P28,Q14012,Q14108,Q7L576 6 +Regulation of lipophagy 0.8531415594246778 1.1381329258508344 0.2550649812557055 1.0 0.8231378456060308 2 O15269 1 +Transmission of nerve impulse 0.632503961875249 1.1369446408690405 0.2555614287755312 1.0 0.8231378456060308 6 Q06787 1 +Oogenesis 0.4917529535099904 1.135890789129513 0.2560022736715974 1.0 0.824131414622216 15 P07686,Q8N2A8,Q9Y5A9 3 +External encapsulating structure organization 0.4713481501677669 1.130386011186601 0.2583136059934958 1.0 0.8288750919802306 19 Q53GQ0,O75955,P05067,Q92791,O75718 5 +Cellular lipid catabolic process 0.4380789674192804 1.1295578641637052 0.2586625742867519 1.0 0.8288750919802306 55 Q13510,Q8NHP8,P23786,Q8WTV0,O14975,P50897,Q8NCC3,P06280,Q15067,P07686,O75874,P04066,Q9BWD1,P17900,P06865 15 +Regulation of calcium ion transmembrane transport 0.4772112969396838 1.1295102465205926 0.2586826495505923 1.0 0.8288750919802306 17 P21796,Q96GC9,Q06787 3 +Regulation of neurotransmitter levels 0.4735589330968576 1.127499444778984 0.2595313751232238 1.0 0.8288750919802306 23 O75955,P49189,P21964,P50897,O00186,Q99808,P16615,Q06787 8 +Protein o linked glycosylation via serine 0.7440363498674782 1.124886300162366 0.2606372180355427 1.0 0.829615194012929 3 Q10471,Q10472 2 +Regulation of protein tyrosine kinase activity 0.5093926194544462 1.1244485798827626 0.2608227728435697 1.0 0.8297815961799003 12 P05067 1 +Very long chain fatty acid metabolic process 0.5830983081042929 1.1214723984829873 0.2620868340064426 1.0 0.8311236744029142 8 Q15067 1 +Leukocyte migration 0.4685205777990656 1.1209981678403218 0.2622886422911068 1.0 0.8311236744029142 38 P14174,P04062,P46108,O94813,P55011,O00429,P35613,P05067,P78310,Q99538,Q07021 11 +Regulation of cell projection organization 0.3988001700898861 1.1193209384221687 0.2630032462747076 1.0 0.8322327302694678 100 Q15375,O94813,Q9UL15,Q14012,Q96G23,P07196,Q14108,Q06787,O14786,Q9NQX7,P46108,O00592,P51114,P11233,Q9H4M9,Q9HCE1,Q32P28,Q16625,Q9NQW6,Q9Y277,Q9UQB8,Q15555,P53990,Q9NR77,P51116 25 +Immune effector process 0.4087404009793646 1.1180252498520244 0.2635562094820036 1.0 0.8325541963766196 64 P14174,O15400,P01889,P46108,Q06481,P09601,P11279,P02786,P05067,P04439,P51809,Q7Z434,Q07021,Q9NUQ9,P53634,Q9UQ84 16 +Chemical homeostasis 0.4533764270662563 1.1175194905836403 0.2637722707285033 1.0 0.8325541963766196 154 Q96CP7,O75503,P30536,P50897,P05067,P53985,O15260,Q9HCL2,Q92544,O75787,P61916,P51790,Q99808,Q16739,Q93050,Q9Y3D6,P35670,P05026,Q5BJF2,P04062,Q06481,P30519,Q8WTV0,Q9H4M9,P42785,Q6P4Q7,Q8TAD4,Q9Y487,Q9Y5P4,P02786,Q8N511,Q9HD20,Q15067,P07686,Q9Y6M7,O15118,P04899,Q15904 38 +Oligodendrocyte development 0.5820364526755722 1.1162944398139707 0.2642961208653984 1.0 0.8325541963766196 8 Q92542 1 +Natural killer cell activation involved in immune response 0.6684746274924076 1.1145701121393408 0.2650346840055233 1.0 0.8325541963766196 4 P11279 1 +Natural killer cell degranulation 0.6684746274924076 1.1145701121393408 0.2650346840055233 1.0 0.8325541963766196 4 P11279 1 +Jnk cascade 0.4945224632439021 1.1123832920414134 0.2659733852542718 1.0 0.8325541963766196 14 O00560,P05067 2 +Iron ion transport 0.5809919909048882 1.1112009371270335 0.2664818679713931 1.0 0.833249174035998 8 P02786 1 +Granulocyte chemotaxis 0.4941438405689716 1.1100756952229278 0.2669664095486364 1.0 0.833249174035998 14 Q07021,P35613,O94813,O00429 4 +Positive regulation of peptidyl serine phosphorylation 0.4939997763681066 1.109197610886322 0.2673449430380525 1.0 0.833249174035998 14 P02786,Q9H7B4,P05067 3 +Response to purine containing compound 0.5061846939335093 1.105605760655656 0.2688971953435488 1.0 0.833249174035998 12 P30520,P05067 2 +Positive regulation of leukocyte proliferation 0.5121142042879917 1.103827299915102 0.2696680600552275 1.0 0.833249174035998 11 P02786,P14174,Q9HCL2,P04439 4 +Regulation of ion transport 0.3962251048150376 1.1032866030968056 0.2699027225734618 1.0 0.833249174035998 67 P05026,P30536,P27105,P05067,P51809,P21796,O75844,P08183,Q8TAD4,P04899,Q96GC9,Q06787 12 +Cysteine metabolic process 0.6646875212160008 1.0987310733693 0.2718853846399085 1.0 0.833249174035998 4 P25325 1 +Atp synthesis coupled electron transport 0.4699444736429062 1.0977777580117445 0.2723015459849094 1.0 0.833249174035998 31 O96000,Q9H3K2,O75208,O14949,O43674,Q9UDW1,O75306,O43676,P20674 9 +Positive regulation of b cell proliferation 0.842165026495076 1.0941308101941507 0.2738976113692191 1.0 0.833249174035998 2 P02786 1 +Regulation of b cell proliferation 0.842165026495076 1.0941308101941507 0.2738976113692191 1.0 0.833249174035998 2 P02786 1 +Cell migration involved in sprouting angiogenesis 0.6224515166510848 1.092600756123935 0.2745691305987952 1.0 0.833249174035998 6 O14786,O94813 2 +Positive regulation of cell projection organization 0.4339122696743692 1.092283604813122 0.2747084644235089 1.0 0.833249174035998 55 O14786,P11233,O94813,Q9UQB8,Q15555,Q9H4M9,Q32P28,P53990,Q14012,Q16625,Q9NQW6,P07196,Q14108,Q7L576,Q06787 15 +Mitochondrion morphogenesis 0.5323807532342499 1.0921961194382197 0.2747469077964029 1.0 0.833249174035998 10 Q9Y3D6,Q9Y5P4 2 +Peptidyl lysine dimethylation 0.7357543590045332 1.0918519573148429 0.27489817732955 1.0 0.833249174035998 3 Q03164 1 +Regulation of chemotaxis 0.4671073935361436 1.091813207396816 0.2749152126369096 1.0 0.833249174035998 21 O14786,O94813,O00429,Q07021,Q99538,Q9NUQ9 6 +Regulation of calcium ion transport 0.4690345815202472 1.0914235848576126 0.2750865392425705 1.0 0.833249174035998 25 P05026,P30536,P21796,Q96GC9,Q06787 5 +Mitochondrion organization 0.4599298393487172 1.0910844918913278 0.2752357060610444 1.0 0.833249174035998 164 Q99595,Q9H3K2,P17152,P12235,O95831,O43819,P30536,Q5JRX3,P55786,O14737,Q99496,Q13501,P21796,P48506,Q9UJZ1,O14925,Q8N5K1,Q13505,Q3ZCQ8,Q6DKK2,Q9BRT2,O96000,Q10713,Q8N2A8,O60830,P45880,P53365,P52789,Q9H061,P51572,O00429,O43615,O75153,Q5XKP0,Q9Y3D6,Q96A26,P04062,P11233,Q9NS69,O43674,Q9NUQ9,Q8N4H5,Q69YU5,Q15388,Q9Y5P4,P14406,P02786,Q96CU9,O43676,O75306,P78310,Q9BUR5,O95140,Q96EY1 54 +Regulation of cation channel activity 0.4839457623271478 1.0874038956405507 0.2768583502913169 1.0 0.8351357019930906 15 P27105,P05067 2 +Regulation of rna splicing 0.3691049099666836 1.0848267724289022 0.2779983855381829 1.0 0.8358336687745112 77 Q8IXT5,P31942,P52597,Q07666,P35637,P09651,P22626,Q06787,O60828,P31943,P62995,P52756,Q96EP5,Q07955,P26368,P17844,P61978,Q9UHX1,P51114,Q15007,Q14011,P38159,Q9UKA9,Q13595,P98179,P55795,Q8IY67,Q5BKZ1,Q01130,Q07021,Q96QD8,P51116,Q9BWF3 33 +Modulation by host of symbiont process 0.4634346330935579 1.0842373577462694 0.2782595717820677 1.0 0.8358336687745112 18 P11717,P27105 2 +Transepithelial chloride transport 0.8395155185465554 1.083545259160595 0.2785664732905666 1.0 0.8358336687745112 2 P51798 1 +Gamma aminobutyric acid signaling pathway 0.8395155185465542 1.0835452591605894 0.278566473290569 1.0 0.8358336687745112 2 P04899 1 +Angiogenesis involved in wound healing 0.8395155185465518 1.0835452591605794 0.2785664732905735 1.0 0.8358336687745112 2 P42785 1 +Cell adhesion mediated by integrin 0.6277830452287754 1.0815957722372116 0.2794321839269309 1.0 0.8360150684626263 5 O00592 1 +Neurotransmitter transport 0.4650258415457867 1.077850580219897 0.2811004429212376 1.0 0.8372460920133356 21 Q06787,O75955,P50897,Q99808,Q96QD8,P16615,O00186 7 +Cotranslational protein targeting to membrane 0.4888273660023859 1.0776526031671316 0.2811888176035793 1.0 0.8372460920133356 14 Q15629,P43307 2 +Regulation of leukocyte proliferation 0.4756903931938874 1.0767757853503643 0.2815804457088919 1.0 0.8379296180999823 16 P14174,P02786,P10644,P04439,Q9HCL2 5 +Positive regulation by host of viral process 0.5503314172605283 1.0754203982494732 0.2821865532819962 1.0 0.8389430259741355 9 P11717 1 +Mitochondrial acetyl coa biosynthetic process from pyruvate 0.6589660113762321 1.0748307515789792 0.2824505098679917 1.0 0.8389430259741355 4 P11177 1 +Positive regulation of oxidoreductase activity 0.5724440956081676 1.0695063336455024 0.2848415764367371 1.0 0.8408836675652562 8 P04899,Q8WTV0 2 +Regulation of release of cytochrome c from mitochondria 0.548551568919417 1.0662578363225372 0.2863071038146541 1.0 0.8418422204796686 9 Q9H3K2,O00429,O14737 3 +Tetrapyrrole catabolic process 0.7292583794863436 1.0660146190546285 0.2864170334596458 1.0 0.8418422204796686 3 P30519 1 +Autophagosome membrane docking 0.834595003785009 1.0639262398099605 0.2873621150162462 1.0 0.8418422204796686 2 Q96GC9 1 +Calcium ion import into sarcoplasmic reticulum 0.8345950037850073 1.0639262398099527 0.2873621150162497 1.0 0.8418422204796686 2 O75844 1 +Multicellular organismal signaling 0.4628457221253103 1.063217570641852 0.2876832960240103 1.0 0.8418422204796686 21 P05026,Q14126,O75844,Q06787 4 +Negative regulation of mitochondrion organization 0.485904685788975 1.059813390725552 0.2892295036104744 1.0 0.8418422204796686 14 P02786,P30536 2 +Negative regulation of organic acid transport 0.7269835097651665 1.056983170113087 0.2905192684296407 1.0 0.8418422204796686 3 Q9Y3D6 1 +Regulation of endothelial cell migration 0.4636172400645209 1.0567748258258385 0.2906143660529616 1.0 0.8418422204796686 24 P42785,Q99538,Q8WTV0 3 +Inner mitochondrial membrane organization 0.4609207332912629 1.0554906935261834 0.2912009635961499 1.0 0.8418422204796686 20 Q9H3K2,P17152,Q13505,Q9BUR5 4 +Cellular response to calcium ion 0.525496528399672 1.054718133050557 0.2915542560799999 1.0 0.8418422204796686 10 Q99538 1 +Negative regulation of protein secretion 0.6133407653849474 1.0524218812783206 0.2926060339279535 1.0 0.8418422204796686 6 Q16850 1 +Lysosomal transport 0.4624417267768386 1.0489332066203618 0.2942088609506197 1.0 0.8418422204796686 33 Q99523,P11717,P11279,P07602,P51809,O15118,P20645,Q14108,Q9NZJ7,Q9UNK0 10 +Regulation of filopodium assembly 0.4962807471266973 1.0473638597352404 0.2949317934086339 1.0 0.8418422204796686 12 Q06787,O14786,P11233,P51116 4 +Regulation of the force of heart contraction 0.6519513452385032 1.0455831670774176 0.2957535242961406 1.0 0.8418422204796686 4 P10253,P16615 2 +Regulation of modification of postsynaptic structure 0.7240249265014939 1.0452510990184511 0.295906932152356 1.0 0.8418422204796686 3 Q9UQB8 1 +Leukocyte degranulation 0.5237301893424503 1.0450987864020271 0.2959773149169984 1.0 0.8418422204796686 10 P09601,P11279,P51809 3 +Negative regulation of atp metabolic process 0.5440597381895662 1.0431315107524644 0.2968873884354601 1.0 0.8418422204796686 9 P30536 1 +Determination of adult lifespan 0.6111198742699803 1.0426314760157307 0.2971190054743022 1.0 0.8418422204796686 6 O75844 1 +Negative regulation of leukocyte migration 0.6511112095588558 1.0420846932420849 0.2973724145443257 1.0 0.8418422204796686 4 P14174,O94813 2 +Regulation of atp metabolic process 0.4609258015956479 1.0417294675067943 0.2975371229920061 1.0 0.8418422204796686 23 P30536,Q9Y3D6,P14406,P05067 4 +Myeloid cell development 0.482856696058992 1.0411996223369555 0.2977829109686334 1.0 0.8418422204796686 14 P05067 1 +Regulation of cell adhesion mediated by integrin 0.6508410790286064 1.040960036774471 0.2978940959874077 1.0 0.8418422204796686 4 O00592 1 +Negative regulation of developmental process 0.3712421527985541 1.040119965339358 0.2982841689608106 1.0 0.8418422204796686 82 Q99523,Q06481,Q15375,P02786,P30536,P05067,Q99538,Q8N4Q0 8 +Negative regulation of receptor mediated endocytosis 0.5885026724402419 1.0388287839455783 0.2988843720335796 1.0 0.8418422204796686 7 P05067 1 +Mitochondrial electron transport cytochrome c to oxygen 0.7220749716016728 1.037527521474803 0.2994900763365171 1.0 0.8418422204796686 3 P00403,P20674 2 +Regulation of mast cell activation involved in immune response 0.827781983345948 1.0368523369703444 0.299804679852818 1.0 0.8418422204796686 2 P51809 1 +Regulation of mast cell activation 0.827781983345948 1.0368523369703444 0.299804679852818 1.0 0.8418422204796686 2 P51809 1 +Negative regulation of chemotaxis 0.6173801357025076 1.0366354269104872 0.2999057962707714 1.0 0.8418422204796686 5 O14786,O94813 2 +Bone development 0.4595737150245093 1.0365812665573475 0.299931047614316 1.0 0.8418422204796686 22 Q15904,Q92896,O75844 3 +Negative regulation of peptidase activity 0.4595051378222338 1.0352011741951372 0.3005749705462139 1.0 0.8418422204796686 35 Q06481,P07858,P05067 3 +Cell killing 0.4575453618236086 1.032944002949337 0.3016301047550471 1.0 0.8418422204796686 20 O15400,P46108,P01889,P11279,P51809,P04439,P53634 7 +Organic hydroxy compound biosynthetic process 0.4407117283712631 1.030904052834817 0.3025858158751904 1.0 0.8418422204796686 49 Q13510,O15270,Q16850,O14975,O15269,O75845,O75477,Q14739,Q9UKR5,Q6P1A2,P48449,Q9UBM7,P04062,P22059,P35270,Q15392,P37268,Q9H2C2,Q14534,P16435 20 +Protein localization to lysosome 0.4932731875471593 1.029661625538117 0.3031688755442911 1.0 0.8418422204796686 12 Q14108 1 +Hematopoietic stem cell homeostasis 0.6479469230016545 1.0289173090958674 0.3035185338873281 1.0 0.8418422204796686 4 Q9NX40 1 +Glutamine transport 0.8255109765329277 1.027852538931726 0.3040191978388793 1.0 0.8418422204796686 2 Q96QD8 1 +Negative regulation of small gtpase mediated signal transduction 0.5202365127022754 1.0260699650101068 0.3048586064170449 1.0 0.8418422204796686 10 O95630,Q9NUQ9,O94813 3 +Carnitine metabolic process 0.6471317763961489 1.0255277328221868 0.3051142466994498 1.0 0.8418422204796686 4 P23786,P49189 2 +Protein o linked glycosylation via threonine 0.8247539742619219 1.024855476161977 0.3054313856278465 1.0 0.8418422204796686 2 Q10472 1 +Maternal placenta development 0.6136868767770123 1.0206959576614174 0.3073985103005019 1.0 0.8418422204796686 5 P07858 1 +Lipoprotein biosynthetic process 0.5840878919977398 1.0183830048809546 0.3084959755996856 1.0 0.8418422204796686 7 Q16739 1 +Mechanoreceptor differentiation 0.5619407719903164 1.0182714290695938 0.3085489822704619 1.0 0.8418422204796686 8 P54802 1 +Positive regulation of vascular associated smooth muscle cell proliferation 0.6448851087028251 1.01619096689278 0.3095384571195834 1.0 0.8418422204796686 4 P04899 1 +Negative regulation of blood circulation 0.7166694051319397 1.016155302890468 0.309555437295971 1.0 0.8418422204796686 3 P16615 1 +Bicarbonate transport 0.8224829674489003 1.015873079270701 0.3096898299761723 1.0 0.8418422204796686 2 Q9Y6M7 1 +Positive regulation of neutrophil migration 0.6122970891789697 1.014701458163827 0.3102481588455004 1.0 0.8418422204796686 5 Q07021 1 +Positive regulation of granulocyte chemotaxis 0.6122970891789697 1.014701458163827 0.3102481588455004 1.0 0.8418422204796686 5 Q07021 1 +Negative regulation of collateral sprouting 0.8205904617713817 1.008398017553517 0.3132634242751737 1.0 0.8418422204796686 2 Q15375 1 +Dsrna processing 0.4832696905553214 1.0062653444482723 0.3142879463795682 1.0 0.8418422204796686 13 P22626,O75844 2 +Multicellular organism growth 0.4562064362606237 1.006028141286453 0.3144020332306685 1.0 0.8418422204796686 24 Q99538,P05067 2 +Calcium ion regulated exocytosis 0.5589140229949939 1.0035114962031508 0.3156141329415085 1.0 0.8418422204796686 8 P04899,Q9BRK5,P16615,P51809 4 +Lipopolysaccharide mediated signaling pathway 0.6095996405161134 1.003072726995908 0.3158257725076019 1.0 0.8418422204796686 5 Q8WTV0 1 +Neutrophil activation involved in immune response 0.8190764572293694 1.0024248388962067 0.3161384505624394 1.0 0.8418422204796686 2 P51809 1 +Negative regulation of calcium ion dependent exocytosis 0.8190764572293697 1.0024248388962067 0.3161384505624394 1.0 0.8418422204796686 2 P04899 1 +Neutrophil degranulation 0.8190764572293694 1.0024248388962067 0.3161384505624394 1.0 0.8418422204796686 2 P51809 1 +Negative regulation of glucose import 0.8190764572293672 1.0024248388961974 0.3161384505624438 1.0 0.8418422204796686 2 Q06481 1 +Negative regulation of glucose transmembrane transport 0.8190764572293672 1.0024248388961974 0.3161384505624438 1.0 0.8418422204796686 2 Q06481 1 +Positive regulation of protein localization to membrane 0.4550961781899842 1.0020470236956318 0.3163208821801078 1.0 0.8418422204796686 23 Q13501,Q9Y3D6,P27105 3 +Odontogenesis of dentin containing tooth 0.609294491466146 1.0017577487454368 0.3164606079998833 1.0 0.8418422204796686 5 P35613 1 +Natural killer cell activation 0.5799892539731436 0.999409182118121 0.3175965135884806 1.0 0.8418422204796686 7 P46379,P11279,P51809 3 +Myelin assembly 0.6407496910071704 0.9990266791915884 0.3177817673770673 1.0 0.8418422204796686 4 O15228,Q9NR77 2 +Neural retina development 0.6070574968911597 0.9921212748162344 0.3211383695551726 1.0 0.8418422204796686 5 P54802,Q15555 2 +3 phosphoadenosine 5 phosphosulfate biosynthetic process 0.8156699470098372 0.9890081068418544 0.3226591752935084 1.0 0.8418422204796686 2 Q8TB61 1 +Reactive oxygen species biosynthetic process 0.5559288660561728 0.9889580646473508 0.3226836595768401 1.0 0.8418422204796686 8 P51790 1 +Neuron death 0.3738192849506852 0.9879719161322856 0.3231664024194303 1.0 0.8418422204796686 70 O14786,O95831,P04062,Q15375,Q92542,Q9UL15,P50897,O95630,Q9UMX5,P05067,P05198,Q99538,Q15392,Q99720,P07196,Q96A26 16 +Granulocyte migration 0.4679623791314615 0.9878939757048484 0.3232045761530915 1.0 0.8418422204796686 15 Q07021,P35613,O94813,O00429 4 +Regulation of steroid hormone biosynthetic process 0.8152914458743366 0.987519357471951 0.3233880980297807 1.0 0.8418422204796686 2 P16435 1 +Regulation of hormone biosynthetic process 0.8152914458743366 0.987519357471951 0.3233880980297807 1.0 0.8418422204796686 2 P16435 1 +Relaxation of cardiac muscle 0.8152914458743349 0.9875193574719436 0.3233880980297843 1.0 0.8418422204796686 2 P05026 1 +Regulation of modification of synaptic structure 0.6375444501345857 0.9857437935322328 0.3242588533985793 1.0 0.8418422204796686 4 Q9UQB8 1 +Negative regulation of ion transport 0.4612973639942964 0.9853952697293272 0.3244299522598033 1.0 0.8418422204796686 16 P21796 1 +Negative regulation of ion transmembrane transport 0.4612973639942964 0.9853952697293272 0.3244299522598033 1.0 0.8418422204796686 16 P21796 1 +Negative regulation of cell projection organization 0.4527403777053824 0.9766709065267988 0.3287321029072123 1.0 0.8421342572519972 26 Q9NQX7,Q9NR77,Q15375,O94813 4 +Regulation of response to biotic stimulus 0.4131037996730118 0.9763716210441572 0.3288803395103616 1.0 0.8421342572519972 58 Q06481,P01889,P46108,P11279,O43657,Q96PK6,P04439,Q07021,Q7Z434,Q9Y5A9,O75844,Q9NUD5,Q9NZ08 13 +Retrograde vesicle mediated transport golgi to endoplasmic reticulum 0.4474555501290623 0.9717746679071788 0.3311626609024092 1.0 0.8430360201423053 19 P24390,Q9Y282 2 +Positive regulation of regulated secretory pathway 0.6022099622335876 0.9712611069586596 0.3314182711614033 1.0 0.8430360201423053 5 P11279 1 +Membrane raft organization 0.5516593705925142 0.9681514488710616 0.3329687383089967 1.0 0.8432278899850133 8 O75955,P50897,O15118 3 +Positive regulation of immune system process 0.3821745586629245 0.9665017589244864 0.3337931672045717 1.0 0.8432278899850133 97 O15400,Q96PK6,P05067,Q07666,Q99538,Q7Z434,Q9HCL2,P01889,O00429,P04439,P46379,Q06481,Q9NUQ9,P53634,P11279,P02786,P51809,Q07021,Q9NUD5,Q14254 20 +Regulation of sodium ion transmembrane transport 0.482390456045927 0.9655740261891816 0.3342573775269857 1.0 0.8432278899850133 12 P27105 1 +Filopodium assembly 0.4763013377758872 0.9644546553373564 0.3348180317581892 1.0 0.8432755120252776 13 Q06787,O14786,P11233,P51116 4 +Chondrocyte differentiation 0.5501412525467586 0.9607560204251924 0.336674856491304 1.0 0.8460810496419767 8 Q92896 1 +Reticulophagy 0.6313358779568089 0.9600704602013374 0.3370197543111501 1.0 0.8463821460598052 4 Q96HY6,Q9Y6I9 2 +Apoptotic dna fragmentation 0.7012398019059487 0.9555000953603844 0.3393248571520195 1.0 0.8466687693707211 3 O00115 1 +Peptidyl proline modification 0.4490642594588478 0.9511109597087288 0.3415480517667708 1.0 0.8466687693707211 26 P62942,P13674,Q9NWM8,Q96AY3,Q32P28,Q9Y680,Q9BV86,O75718 8 +Regulation of macrophage activation 0.6291204757084525 0.950928487137658 0.3416406795615558 1.0 0.8466687693707211 4 P53634 1 +Outer mitochondrial membrane organization 0.5966346820662722 0.947310496353133 0.343480583804358 1.0 0.84875949015243 5 Q9NS69 1 +Leukocyte chemotaxis 0.4485053220492601 0.9472232476208295 0.3435250315576221 1.0 0.84875949015243 26 P14174,O94813,P35613,O00429,P78310,Q99538,Q07021 7 +Negative regulation of immune effector process 0.5472467120487265 0.9466602897813396 0.3438119115631766 1.0 0.84875949015243 8 P04439,P46108,P01889 3 +Cardiac septum development 0.5470002392340921 0.9454603442387132 0.3444239071264598 1.0 0.84875949015243 8 O96028,O14786,Q13308,O94813 4 +Synapse assembly 0.4608487093687269 0.9435436167438416 0.3454029164992584 1.0 0.84875949015243 15 Q15375,P05067 2 +Cellular homeostasis 0.4069059372152209 0.9425611717827888 0.3459054081662187 1.0 0.84875949015243 122 O75503,O43819,P50897,P05067,P48506,Q9UJZ1,Q92544,O76024,Q9NQC3,O75787,P55011,P52789,P51790,Q99808,P61421,P16615,Q93050,Q9Y3D6,P35670,P05026,P62942,P22059,P09601,Q8TAD4,Q96A33,Q12824,O00186,P10253,Q9Y487,P02786,Q8N511,P05023,Q9HD20,P51149,P07686,Q9Y6M7,O95563,Q15904 38 +Negative regulation of steroid metabolic process 0.6976715993981657 0.9415555108621858 0.3464202562736704 1.0 0.84875949015243 3 O75477 1 +Negative regulation of cation channel activity 0.5950537755406163 0.940527958850098 0.3469468152989461 1.0 0.8492712309460151 5 Q06787 1 +Glucosamine containing compound metabolic process 0.6264901796655538 0.9400882627550916 0.3471722888292725 1.0 0.8492712309460151 4 Q01459 1 +Membrane repolarization during cardiac muscle cell action potential 0.6258478652980599 0.9374434466191554 0.348530501329066 1.0 0.8501465345756626 4 P05026 1 +Membrane repolarization during action potential 0.6258478652980599 0.9374434466191554 0.348530501329066 1.0 0.8501465345756626 4 P05026 1 +Cell communication by electrical coupling involved in cardiac conduction 0.6243015304644733 0.9310800883534472 0.3518121376453704 1.0 0.8512227075867983 4 P05026 1 +Positive regulation of interferon gamma production 0.6241048180945166 0.9302709912983144 0.3522307934202531 1.0 0.8512227075867983 4 P04439 1 +Second messenger mediated signaling 0.4420980075897978 0.9295675229740143 0.3525950492981171 1.0 0.8512227075867983 20 Q9Y3D6,O75844 2 +Multicellular organism aging 0.5217894840514159 0.9285247561829664 0.3531354322789961 1.0 0.8512227075867983 9 O75844 1 +Retinal metabolic process 0.7997728993186966 0.9268504921983256 0.3540041649091141 1.0 0.8512227075867983 2 Q8NBN7 1 +Cellular modified amino acid catabolic process 0.5845451689634524 0.9257352509978646 0.3545835836219844 1.0 0.8512227075867983 6 Q9UHG3 1 +Vacuolar transport 0.4441159107116705 0.9250540966496794 0.3549377688159705 1.0 0.8512227075867983 36 Q96L92,P11717,Q99523,P11279,P07602,P51809,P61421,O15118,P20645,Q14108,Q9NZJ7,Q9UNK0 12 +L glutamate import across plasma membrane 0.6933445827886213 0.9246913540961772 0.3551264780207481 1.0 0.8512227075867983 3 Q15041 1 +Regulation of amino acid transmembrane transport 0.6933445827886213 0.9246913540961772 0.3551264780207481 1.0 0.8512227075867983 3 Q15041 1 +Regulation of l glutamate import across plasma membrane 0.6933445827886213 0.9246913540961772 0.3551264780207481 1.0 0.8512227075867983 3 Q15041 1 +Anatomical structure homeostasis 0.4454776795060323 0.9230653595972826 0.3559731454135515 1.0 0.8512227075867983 32 P38571,P10253,Q15555,P02786,P51790,P78310,Q16625,O14773 8 +Glycosylceramide catabolic process 0.6916597719380371 0.9181391159455404 0.3585460385864398 1.0 0.8523511402211433 3 P06280 1 +Histone h3 k4 demethylation 0.6892483972394545 0.908775562332638 0.3634686086517891 1.0 0.8588066631749673 3 Q8NB78 1 +Ventricular septum morphogenesis 0.7944738834216459 0.9063127696376172 0.3647703284919439 1.0 0.8606691765605379 2 O94813 1 +Biological process involved in interaction with host 0.4292387312651139 0.90476984734152 0.3655873288972315 1.0 0.8606691765605379 47 O14786,P11279,P07858,Q8WTV0,P02786,P35613,P53990,O15118,P08195,Q9BTY2,Q14108 11 +Leukocyte mediated immunity 0.433237669861167 0.900965634904842 0.3676065915989794 1.0 0.8606691765605379 44 O15400,P46108,P01889,P11279,P09601,P02786,P51809,P04439,Q07021,Q7Z434,Q9NUQ9,P53634,Q9UQ84 13 +Axonal fasciculation 0.7929598788796346 0.9004628709366913 0.3678739757452369 1.0 0.8606691765605379 2 O14786 1 +Branching morphogenesis of a nerve 0.7929598788796323 0.900462870936683 0.3678739757452414 1.0 0.8606691765605379 2 Q15375 1 +Mitotic nuclear membrane organization 0.5853237112315353 0.8988802131066703 0.368716468505776 1.0 0.8610162743344661 5 Q86XL3 1 +Regulation of endoplasmic reticulum unfolded protein response 0.5573162689365901 0.8946926343884929 0.3709514171609993 1.0 0.8610162743344661 7 P18031,P57088,O76024 3 +Sterol transport 0.4354882887926583 0.8920776035526481 0.3723513384232586 1.0 0.8610162743344661 19 Q8WTV0,P30536,P61916,Q9H2C2,O15118 5 +Positive regulation of actin cytoskeleton reorganization 0.5835684845374808 0.8913867170566397 0.3727217412262507 1.0 0.8610162743344661 5 Q9UQB8 1 +Cell communication by electrical coupling 0.5835210480925017 0.8911842879722129 0.3728303121189293 1.0 0.8610162743344661 5 P05026 1 +Gene silencing by rna 0.4398880761229294 0.8894756399848528 0.3737475093993208 1.0 0.8610162743344661 35 Q01085,Q9HCE1,O75844,P22626,O75569,Q5KU26,P51114,Q06787 8 +Negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator 0.6841895490255692 0.8891884253621883 0.3739018223464896 1.0 0.8610162743344661 3 P14174 1 +Regulation of cardiac muscle contraction by calcium ion signaling 0.6140164139604893 0.8889047917444467 0.3740542499934776 1.0 0.8610162743344661 4 P05026 1 +Calcium mediated signaling using intracellular calcium source 0.7899318697956057 0.8887879153252886 0.3741170717752724 1.0 0.8610162743344661 2 Q9Y3D6 1 +Negative regulation of axonogenesis 0.5758738641752588 0.887753905440237 0.3746731425883962 1.0 0.8610162743344661 6 O14786,Q8N0X7,Q15375 3 +Neuron apoptotic process 0.4235072430741166 0.8855242189518953 0.3758739632132868 1.0 0.8610162743344661 49 P04062,Q15375,P50897,O95630,P05067,Q99720,Q99538,Q92542 8 +Response to iron ion 0.6131433396544624 0.885337397046544 0.3759746858506425 1.0 0.8610162743344661 4 P02786,P36551 2 +Sulfur amino acid biosynthetic process 0.5818419020844959 0.8840218211287302 0.3766844334658943 1.0 0.8610162743344661 5 Q13126 1 +Positive regulation of plasma membrane bounded cell projection assembly 0.4377859492728419 0.8839765913328593 0.3767088494357227 1.0 0.8610162743344661 23 O14786,P11233,Q15555,Q16625,Q9NQW6,Q06787 6 +Positive regulation of i kappab kinase nf kappab signaling 0.4390928875802212 0.880511735677052 0.3785821504603781 1.0 0.8618107746860382 34 P62942,Q8TB61,P02786,O43657,Q9Y3E0,Q7Z434,Q5T9L3 7 +Metal ion transport 0.3598612697958863 0.879263667574115 0.3792583306316395 1.0 0.8624040783464527 84 P05026,P02786,P30536,O00429,O15173,P27105,Q9HD20,P35670,P21796,O75844,Q9Y6M7,Q96QD8,P08195,Q8TAD4,P04899,Q96GC9,Q06787 17 +Amino acid import 0.5325663174496456 0.8753028560863756 0.3814091405156401 1.0 0.8638160815769542 8 Q96NB2,Q15758,Q15041,P08195 4 +Regulation of rig i signaling pathway 0.5729687897484302 0.8750545859678477 0.381544205643531 1.0 0.8638160815769542 6 Q9NUD5 1 +Glycine biosynthetic process 0.6800454373343493 0.8732030035330332 0.3825524380271576 1.0 0.8650543556990731 3 P00374,P34896 2 +Water homeostasis 0.5724350744665788 0.8727230077327273 0.3828140739147003 1.0 0.8650543556990731 6 Q16739 1 +Regulation of anion transport 0.5319972429823486 0.8725423572704522 0.3829125711780254 1.0 0.8650543556990731 8 P55011,P14174,Q15041,P08183 4 +Positive regulation of defense response 0.4379764908720453 0.8722651551241541 0.3830637421558536 1.0 0.8650543556990731 34 P11279,Q96PK6,P05067,P51809,Q99735,P53634,Q9NUD5 7 +Phosphatidylglycerol metabolic process 0.4915437460245526 0.869899981947429 0.3843550653371586 1.0 0.8660856448748278 10 P40939,Q8NCC3,Q92604,Q9HCL2 4 +Maintenance of blood brain barrier 0.5781506427085565 0.8682983772302526 0.385231010319196 1.0 0.8671920204427706 5 P55011,Q16625 2 +Regulation of phospholipid catabolic process 0.6785827635905552 0.8675743562661751 0.3856273898730245 1.0 0.8671920204427706 3 Q8WTV0 1 +Negative regulation of anoikis 0.6785308595229027 0.8673747512169606 0.3857367113920815 1.0 0.8671920204427706 3 P05556,Q9Y3E5 2 +Negative regulation of response to biotic stimulus 0.4314652407562391 0.865277076722424 0.3868867294612594 1.0 0.8680334788137312 19 P46108,P01889,O43657,P04439,Q07021 5 +Regulation of fatty acid transport 0.5768640299990243 0.8628251957234054 0.3882335839771285 1.0 0.8697885188346894 5 Q9Y3D6 1 +Post embryonic development 0.4901440281253488 0.8622984375136131 0.3885233123500515 1.0 0.8698116298782528 10 P11717,O95470 2 +Motor neuron axon guidance 0.607033109527656 0.8604316674025081 0.3895511358475887 1.0 0.8699230171402752 4 O94813 1 +Methionine biosynthetic process 0.6067600070193223 0.8593210522531838 0.3901634125364017 1.0 0.8700452426432239 4 Q13126 1 +Methionine metabolic process 0.6067600070193223 0.8593210522531838 0.3901634125364017 1.0 0.8700452426432239 4 Q13126 1 +Cellular response to estradiol stimulus 0.6763683842857333 0.8590667559649473 0.390303687095785 1.0 0.8700452426432239 3 Q14103 1 +Muscle structure development 0.3534155710872758 0.8584276721795475 0.3906563528792492 1.0 0.8700452426432239 80 Q99523,P51114,O75955,Q9NWT6,P50402,Q9H4M9,P10644,P78310,Q9BYT8,Q14012,O75844,Q9H7B4,Q9NR12,P16615,Q8IV08,Q9BRT2,Q14254,Q9BWF3 18 +Regulation of perk mediated unfolded protein response 0.7819833459500359 0.8583054529165368 0.3907238192146569 1.0 0.8700452426432239 2 P57088 1 +Positive regulation of endoplasmic reticulum unfolded protein response 0.7819833459500359 0.8583054529165368 0.3907238192146569 1.0 0.8700452426432239 2 P57088 1 +Positive regulation of ire1 mediated unfolded protein response 0.7819833459500359 0.8583054529165368 0.3907238192146569 1.0 0.8700452426432239 2 P57088 1 +Regulation of heart contraction 0.4301520299738579 0.8565294657727175 0.3917049815716966 1.0 0.8719182035271302 19 Q14126,P10253,O75844 3 +Regulation of lamellipodium organization 0.440833547530936 0.8552697791990922 0.3924018138622682 1.0 0.8727746472807859 16 Q16625 1 +Regulation of autophagy of mitochondrion in response to mitochondrial depolarization 0.567067422644896 0.8493020419434589 0.3957132449245861 1.0 0.8742121910935475 6 P04062,O95140 2 +Rig i signaling pathway 0.4873198940671424 0.8469696852316074 0.3970120187172057 1.0 0.8742121910935475 10 Q9NUD5 1 +Regulation of carbohydrate metabolic process 0.4347072641162646 0.8464077066028876 0.3973253407723458 1.0 0.8742121910935475 28 Q14108,P05067 2 +Carbohydrate metabolic process 0.4015320554441201 0.8459960821378129 0.3975549298893428 1.0 0.8742121910935475 125 P10253,P48735,P16278,O00462,P08236,P06280,P05067,P07686,O75874,O75844,P04066,O00754,O43505,Q9BTY2,Q14108,Q9NUJ1,P17900,P06865 18 +Artery morphogenesis 0.6727783866038949 0.845310234648343 0.3979376482217405 1.0 0.8742121910935475 3 O14786 1 +Positive regulation of cell cell adhesion 0.4319515735092514 0.8441477652417955 0.398586839181096 1.0 0.8742121910935475 23 O75955,P02786,P04439,O00592,Q9HCL2,Q14254 6 +Manganese ion transport 0.7781983345950004 0.8438777514594564 0.3987377219064454 1.0 0.8742121910935475 2 Q9HD20 1 +Manganese ion transmembrane transport 0.7781983345950004 0.8438777514594564 0.3987377219064454 1.0 0.8742121910935475 2 Q9HD20 1 +L aspartate transmembrane transport 0.6717152593714515 0.841245245769627 0.4002105578425889 1.0 0.8742121910935475 3 Q9UJS0,Q15758 2 +Oxaloacetate transport 0.7774413323239941 0.8409992811438713 0.4003483371307177 1.0 0.8742121910935475 2 Q9UBX3 1 +Succinate transmembrane transport 0.7774413323239941 0.8409992811438713 0.4003483371307177 1.0 0.8742121910935475 2 Q9UBX3 1 +Cellular response to arsenic containing substance 0.5254063916908912 0.8406097127614174 0.4005666156719019 1.0 0.8742121910935475 8 P09601,O00571,P09651,Q96QD8 4 +Response to electrical stimulus 0.5647714420891632 0.8393004235694891 0.4013007456063859 1.0 0.8742121910935475 6 P30520,Q14103 2 +Regulation of myeloid leukocyte mediated immunity 0.5248814193967917 0.8380695207930318 0.4019916597254862 1.0 0.8751204304737199 8 P09601,Q7Z434,P51809 3 +Regulation of lamellipodium assembly 0.4439265801252053 0.83805683454433 0.4019987843165498 1.0 0.8751204304737199 15 Q16625 1 +Positive regulation of peptidase activity 0.4333060398751241 0.8377557276999807 0.4021679080072138 1.0 0.8751825918395362 34 Q92542,O95831,O14737,P05067,Q99538,Q9Y3D6,Q9NZJ7 7 +Regulation of protein lipidation 0.7763058289174829 0.8366860741999772 0.4027690488520228 1.0 0.8758784834623451 2 P04062 1 +Regulation of lipoprotein metabolic process 0.7763058289174829 0.8366860741999772 0.4027690488520228 1.0 0.8758784834623451 2 P04062 1 +Blood vessel endothelial cell migration 0.4264512882298155 0.8318821189285232 0.4054754857490978 1.0 0.878242137880281 19 P42785,O94813,Q8WTV0 3 +Fat cell differentiation 0.4264318149756329 0.8317524466606807 0.4055486903960501 1.0 0.878242137880281 19 Q99523,Q8N4Q0,Q9NZ08 3 +Regulation of developmental growth 0.4268718262368735 0.8308560998957164 0.4060549262079753 1.0 0.8784648472828306 42 O14786,Q15375,P05067,P53990,Q99538,O75844,O95470,Q99956,Q9HCL2 9 +Regulation of peptidyl serine phosphorylation 0.4310551682753634 0.8304817580520223 0.4062664574303873 1.0 0.8784648472828306 17 P02786,Q9H7B4,P05067 3 +Amyloid precursor protein catabolic process 0.4422857774867199 0.8278390749938288 0.4077616421675922 1.0 0.8784778582569249 15 Q92542,O95197,Q15392 3 +Homophilic cell adhesion via plasma membrane adhesion molecules 0.5685944245821757 0.8277445765714032 0.4078151684147284 1.0 0.8784778582569249 5 Q14126,Q14574 2 +Response to dexamethasone 0.5018487362683081 0.8262676733453902 0.4086522669710237 1.0 0.8784778582569249 9 P04062,Q9H7B4 2 +Ephrin receptor signaling pathway 0.5985098600923326 0.8258814881194984 0.4088713226968132 1.0 0.8784778582569249 4 Q15375 1 +Regulation of cation transmembrane transport 0.4251270747527194 0.8258260050734623 0.4089028000688353 1.0 0.8784778582569249 43 P05026,P27105,P05067,P21796,Q96GC9,Q06787 6 +Axoneme assembly 0.6660814605164804 0.8197735637993862 0.412345204255482 1.0 0.8808790309060778 3 A0AVF1 1 +Regulation of protein secretion 0.4308907867194445 0.818088798831443 0.4133064843391132 1.0 0.8808910961226291 33 Q16836,P22059,P55011,O00429,P00367,P53985,Q16850,Q32P28,Q5T9L3,O95563,Q9BRT2 11 +Er overload response 0.5658941080268095 0.8163288542538086 0.4143120757027319 1.0 0.8808910961226291 5 O76024,Q96A33,Q9UM00 3 +Neurotransmitter secretion 0.4346972540719831 0.8162805942760649 0.4143396707012976 1.0 0.8808910961226291 16 P50897,O00186,P16615,Q06787 4 +Regulation of ion transmembrane transport 0.4075617980288183 0.8148529737276422 0.4151564740891309 1.0 0.8820339005567602 53 P05026,P27105,P05067,P21796,O75844,P08183,Q8TAD4,Q96GC9,Q06787 9 +Histone h4 acetylation 0.434218332824948 0.8132393200122054 0.4160808597083663 1.0 0.8820339005567602 16 O75844 1 +Cytokine production involved in immune response 0.4806012390045513 0.8105552634752893 0.4176211166106713 1.0 0.8845282463468755 10 P09601,P14174,P04439,Q7Z434 4 +Acidic amino acid transport 0.5188531483915605 0.8089397503457889 0.4185498029134638 1.0 0.8845282463468755 8 O75915,P55011,Q15041,O60831 4 +Regulation of anion transmembrane transport 0.5639311596835495 0.8080434386044473 0.4190655763459159 1.0 0.8850414784021956 5 P08183,Q15041 2 +Regulation of small gtpase mediated signal transduction 0.4295810438302317 0.8074624946202573 0.419400074230148 1.0 0.8851474109006446 32 O14786,O75955,P46108,O94813,Q15555,O95630,Q13501,Q9NUQ9,O95140 9 +Heart process 0.4270416469527767 0.8057664610396549 0.4203775199527793 1.0 0.8869096710355824 24 P05026,Q14126,P10253,O00429,P78310,O75844,P16615,P04899 8 +Membrane biogenesis 0.4228986749564252 0.8009381930436889 0.4231674279868707 1.0 0.8897806169018091 20 Q96CP7,O75955,Q86XL3,Q16739,Q14254 5 +Regulation of intrinsic apoptotic signaling pathway in response to dna damage by p53 class mediator 0.5919233538954918 0.7993501469237473 0.4240874089221826 1.0 0.8905385969307247 4 P14174 1 +Retina homeostasis 0.660473016705602 0.7985204595686294 0.4245685251009512 1.0 0.8905385969307247 3 P51790 1 +Multicellular organism reproduction 0.3786487778129842 0.7983020975409569 0.4246952011109599 1.0 0.8905385969307247 107 Q7Z7E8,O60879,P41208,P07858,O94813,Q9BQE5,Q99496,P05067,Q07666,Q9H2V7,P11717,P53350,Q8N2A8,Q08J23,P54619,Q9H8Y8,P46379,O95470,Q01085,P35613,Q9BTX1,O95067,O75718,A0AVF1,Q15067,P78310,P07686,Q9Y5A9,Q8NB78,Q9H0H5 30 +Cell activation involved in immune response 0.4280786126073598 0.7974696984736231 0.4251782943409643 1.0 0.8905385969307247 33 P02786,P11279,Q9UQ84,P05067 4 +Protein processing involved in protein targeting to mitochondrion 0.6600995231030314 0.7971096136671388 0.4253873734776703 1.0 0.8905385969307247 3 Q10713 1 +Regulation of peptidyl tyrosine phosphorylation 0.4264050188605374 0.7902680478736397 0.4293712429180782 1.0 0.8923197665204976 27 O14786,P14174,Q9H223,Q15375,Q99816,P61225,P05067,Q9H2J4 8 +Porphyrin containing compound metabolic process 0.447214481286289 0.790124786069455 0.4294548959116131 1.0 0.8923197665204976 13 P30536,P30519,P36551,O00264 4 +Neuron projection regeneration 0.4947421884893181 0.7899883239554919 0.4295345872569758 1.0 0.8923197665204976 9 P30536 1 +Magnesium ion transport 0.7634367903103685 0.7881981561587323 0.4305808074811901 1.0 0.8927059964628397 2 Q6P4Q7 1 +Cobalt ion transport 0.7634367903103669 0.7881981561587275 0.430580807481193 1.0 0.8927059964628397 2 Q8TAD4 1 +Regulation of nervous system development 0.3977877872022366 0.7866811577584911 0.4314685368476512 1.0 0.893148221040488 56 O14786,Q15375,O94813,Q06481,Q9UQB8,P30536,P53990,Q96P11,Q9Y5A9,Q96G23,P07196,P53634,P55209 13 +Protein exit from endoplasmic reticulum 0.4195621940572945 0.7860297022648728 0.431850086231921 1.0 0.893148221040488 19 Q9HCU5,P51572,Q9NR31,O15260,Q96CS3,Q9BUN8,Q92544 7 +Mitochondrial electron transport nadh to ubiquinone 0.4215566413111176 0.785155050073999 0.4323626664672995 1.0 0.893148221040488 21 O96000,O75306,O43676,O75208 4 +Tetrapyrrole metabolic process 0.4409370339901602 0.7850457078367047 0.432426770040063 1.0 0.893148221040488 14 P30536,P30519,P36551,O00264 4 +Respiratory chain complex iv assembly 0.5582965975329386 0.7843249522702013 0.4328494617795555 1.0 0.893148221040488 5 O43819,Q15070 2 +Mitochondrial cytochrome c oxidase assembly 0.5582965975329386 0.7843249522702013 0.4328494617795555 1.0 0.893148221040488 5 O43819,Q15070 2 +Ion transport 0.4437053617684519 0.7841829801469838 0.4329327504247953 1.0 0.893148221040488 177 P12235,Q8TB61,P30536,Q9UDW1,P07602,P05067,P53985,Q96ES6,P21796,Q9UBX3,Q9C0H2,P08195,Q9Y619,P08183,Q06787,P14174,P45880,P51798,P55011,O00429,P27105,P51790,Q15041,Q99808,Q00325,O75844,P61421,P16615,P35670,Q96GC9,O75964,P05026,P62942,Q9H2D1,Q9UHG3,Q6P4A7,O60831,P24539,O43681,Q15758,Q6P4Q7,Q9UHQ9,O43772,Q70HW3,Q8TAD4,Q96NB2,Q9Y277,Q9Y5P4,P12236,P02786,Q13423,P05023,O15173,Q9HD20,P51809,Q9Y6M7,Q96QD8,O95563,P04899,Q9NZJ7,Q9H0H5 61 +Protein o linked glycosylation 0.4514254537730418 0.7835005658350453 0.433333221541667 1.0 0.893148221040488 12 Q10472,O60502,O43505,Q10471 4 +Renal system vasculature development 0.7615442846328507 0.7811318592008932 0.4347249456032871 1.0 0.8934144486543605 2 O14786 1 +Hair follicle maturation 0.5869658376321774 0.7794859793042133 0.4356934935717853 1.0 0.8943711477012646 4 Q08J23 1 +Glucosylceramide metabolic process 0.6548846419616055 0.7774718160658061 0.436880456313526 1.0 0.894810412213788 3 Q16739 1 +Phosphatidylinositol 3 kinase signaling 0.4921199233153013 0.7766306061636694 0.4373767389313863 1.0 0.894810412213788 9 Q07021,O95630 2 +Stem cell proliferation 0.4740967591054673 0.7753879058849983 0.4381104793948673 1.0 0.894810412213788 10 P08183,P04062,P26583,Q9Y5A9 4 +Negative regulation of signal transduction by p53 class mediator 0.5560202578291012 0.7747713216613887 0.4384747982158914 1.0 0.894810412213788 5 P14174,Q8N2F6 2 +Hindbrain development 0.4250415599840439 0.7744419590084285 0.438669478832888 1.0 0.894810412213788 32 P04062,Q14103,P46108,O14949,O95456,P54802,Q5T9L3,Q92542,Q5KU26 9 +Endothelial cell migration 0.4246239401254593 0.7732798150367036 0.4393567989298987 1.0 0.894810412213788 29 P42785,Q99538,Q8WTV0 3 +Regulation of glucan biosynthetic process 0.5840909090909172 0.7680105344781912 0.4424809263594975 1.0 0.8994078509677544 4 P49841,P62140,P31751 3 +Regulation of glycogen metabolic process 0.5840909090909172 0.7680105344781912 0.4424809263594975 1.0 0.8994078509677544 4 P49841,P62140,P31751 3 +Pyrimidine containing compound transmembrane transport 0.7577592732778169 0.7670515013564566 0.4430508955524674 1.0 0.8996852171264391 2 Q99808 1 +Negative regulation of cell differentiation 0.3734041110173552 0.7600153497061644 0.4472454097214984 1.0 0.9040746496513146 64 Q99523,Q06481,Q15375,P30536,P05067,Q8N4Q0 6 +Cardiac conduction 0.4311081200855217 0.7583396030266214 0.4482477045729021 1.0 0.9052465634786432 15 P05026,Q14126,P78310,O75844,P16615 5 +Positive regulation of axonogenesis 0.4303639117549069 0.7537207745058646 0.4510169047932035 1.0 0.908420030356006 15 P07196,O14786,O94813,P53990 4 +Regulation of protein tyrosine phosphatase activity 0.7539742619227819 0.753042739754083 0.4514242313220751 1.0 0.908420030356006 2 P04899 1 +Nuclear ncrna surveillance 0.5799242424242483 0.7514393204310579 0.4523883062541811 1.0 0.9088640189540276 4 Q01780,Q9NQT5,Q15024 3 +Odontogenesis 0.544109523315628 0.7498373600447967 0.453352664684709 1.0 0.9102140246136724 6 P35613 1 +Positive regulation of macroautophagy 0.4347789144907394 0.7475645667956696 0.4547228439306336 1.0 0.9109816709202998 14 P21796,P12235,O15269,O15270 4 +Negative regulation of defense response 0.421083362322765 0.7466380380143471 0.4552820810473199 1.0 0.9110256504512652 30 P04062,P46108,P01889,O43657,P04439,Q07021,Q6P1A2,P28070 8 +Ventricular septum development 0.5429899612986424 0.7450222555796435 0.4562582658282104 1.0 0.9122234948768264 6 O96028,Q13308,O94813 3 +Leukocyte differentiation 0.4098191379411541 0.7432792253715784 0.4573126464709622 1.0 0.9140380535885108 47 P04062,P01889,P02786,P24390,P05067,Q14739,Q15904 7 +Mitochondrial membrane organization 0.4122613187718927 0.7413119609143801 0.4585043111010942 1.0 0.9140948362160416 45 P12235,P17152,Q9H3K2,P05141,O95202,O14737,P48506,Q8IXI2,Q13505,Q3ZCQ8,P45880,P52789,Q15070,Q5XKP0,Q9NS69,Q6UXV4,Q9NX63,Q9Y276,Q9BUR5,O95140 20 +Lipid droplet organization 0.5420279339172662 0.7408877212852034 0.4587615210351505 1.0 0.9140948362160416 6 Q14534,Q96CS3,Q8N0X7 3 +Trna wobble base modification 0.5477783043054245 0.740329460970292 0.4591001088447348 1.0 0.9140948362160416 5 Q2VPK5 1 +Trna wobble uridine modification 0.5477783043054245 0.740329460970292 0.4591001088447348 1.0 0.9140948362160416 5 Q2VPK5 1 +Tor signaling 0.4280258969110537 0.7392186960521939 0.459774209845762 1.0 0.9140948362160416 15 O75844 1 +Action potential 0.411187121105898 0.7386479027346267 0.4601208282964066 1.0 0.9140948362160416 18 P05026,Q14126,P04062,P78310,P16615,Q06787 6 +Regeneration 0.4184946415276782 0.73834696910281 0.4603036313132391 1.0 0.9140948362160416 26 P30536,P11717 2 +Negative regulation of cytokine production 0.4132118719139305 0.7361536165696034 0.4616372162658244 1.0 0.9141626607275048 20 P30536,P04062,Q06481 3 +Renal system process 0.5035470601754761 0.7353687063373936 0.4621149749449391 1.0 0.9141626607275048 8 Q99538 1 +Negative regulation of leukocyte apoptotic process 0.6432869943065274 0.7342314404250334 0.4628076946053798 1.0 0.9141626607275048 3 Q9HCL2 1 +Negative regulation of lymphocyte apoptotic process 0.6432869943065274 0.7342314404250334 0.4628076946053798 1.0 0.9141626607275048 3 Q9HCL2 1 +Response to sodium arsenite 0.7482967448902318 0.7321690410426647 0.4640653979591107 1.0 0.9162353843808264 2 P07196 1 +Response to testosterone 0.4655131328186487 0.7291428331186193 0.465914295884918 1.0 0.9169208089085864 10 Q13126,P04062,P30536 3 +Hematopoietic stem cell proliferation 0.5444385883186443 0.726444402720442 0.4675663790228914 1.0 0.9186078497306792 5 P04062 1 +Mitochondrion endoplasmic reticulum membrane tethering 0.6406905125214325 0.7246380645552879 0.4686741005472843 1.0 0.9196351297346416 3 Q96GC9 1 +Regulation of dna methylation 0.5010008080776714 0.7231948179873924 0.4695602020571314 1.0 0.920162418190231 8 O75844,Q8NB78 2 +T cell activation 0.4121764929021276 0.7222211494646802 0.4701585222998656 1.0 0.9204514069045484 43 P04062,O96005,P02786,P24390,P10644,P04439,Q9NUQ9,Q92542,Q9HCL2,Q14254 10 +Fatty acid derivative biosynthetic process 0.4407093235342064 0.7208571015914127 0.4709974388104152 1.0 0.9215682130841124 12 P50897 1 +Regulation of cytoplasmic translation 0.4302232741998876 0.7198967575507685 0.4715885645573068 1.0 0.921855699508255 14 O60506,Q14103,Q06787 3 +Humoral immune response 0.4398771768778056 0.716006099877011 0.473987582410813 1.0 0.924624063986758 12 P04439,Q07021,Q9UQ84 3 +Regulation of oxidative phosphorylation 0.5361826598949022 0.7158292689574064 0.4740967772280346 1.0 0.924624063986758 6 P14406 1 +Androgen metabolic process 0.5418406723603237 0.7156737189145057 0.4741928423240793 1.0 0.924624063986758 5 Q8NBQ5 1 +Response to corticosteroid 0.4128163356559375 0.7081964848583794 0.4788232487670503 1.0 0.9298669827896616 24 P04062,O95831,P16278,O94813,Q9H7B4,P16435 6 +Negative regulation of leukocyte chemotaxis 0.6359516066621302 0.7072164054122184 0.4794320050875078 1.0 0.9299451787469878 3 O94813 1 +Fatty acyl coa metabolic process 0.4279283471569339 0.7059816121160002 0.480199572569121 1.0 0.9299451787469878 14 P50897 1 +Cellular modified amino acid metabolic process 0.4007262333716683 0.7057938209034859 0.4803163652828994 1.0 0.9299451787469878 50 P23786,P49189,Q9H2D1,Q9UHG3,P07858,Q9H7Z7,Q8NCC3,O60725,Q92820,Q99735,O75874 11 +Endothelial cell proliferation 0.4276748904268637 0.7044458025449248 0.4811551906538835 1.0 0.9308738369660076 14 O14786,Q9H2J4,Q8WTV0 3 +Response to acid chemical 0.4046554200622804 0.695594115517492 0.4866830523997461 1.0 0.9326316414714008 18 Q15388,O95831,Q14103,Q9UQB8,Q99729 5 +Endothelial cell chemotaxis 0.5365289903846427 0.6937389221463839 0.4878459522083944 1.0 0.9326316414714008 5 Q99538 1 +Fatty acyl coa biosynthetic process 0.4409288715248656 0.6935164750215493 0.4879854904066412 1.0 0.9326316414714008 11 P50897 1 +Actomyosin contractile ring organization 0.5355909055906579 0.6898776754029453 0.4902711160464195 1.0 0.933546482454132 5 Q9NQW6 1 +Regulation of lipid metabolic process 0.4004700877933609 0.6898010964474809 0.4903192790788226 1.0 0.933546482454132 49 Q13510,Q06481,Q96N66,Q8WTV0,Q9H6K4,P30536,P61916,O75477,P07602,Q9H2C2,O75874,O75844,Q96G23,Q6P1A2,Q9UBM7,P16435 16 +Positive regulation of immune response 0.3571690263114039 0.6892758921314067 0.4906496659597199 1.0 0.9336133096804914 67 O15400,P01889,Q06481,P11279,P02786,Q96PK6,P51809,Q07666,P04439,Q07021,Q9NUQ9,Q9NUD5,P46379 13 +Inorganic ion import across plasma membrane 0.5295574674764236 0.6875678811121639 0.491724940250569 1.0 0.9338770717181576 6 P05026,P55011,P05023 3 +Negative regulation of secretion 0.4290932659799271 0.6822451725239516 0.4950839353520893 1.0 0.9360752240969056 13 Q06787,Q16836,P09601,Q16850,P40939,P04899,O00186 7 +Regulation of necrotic cell death 0.4388592549447896 0.6817237006094403 0.4954136780586355 1.0 0.9360752240969056 11 Q13510 1 +Regulated exocytosis 0.4118816082867116 0.6808392249921992 0.4959732272032813 1.0 0.9363036120581048 30 P11279,P09601,O00186,O43760,P51809,Q9BRK5,P16615,P04899,Q06787 9 +Skeletal muscle acetylcholine gated channel clustering 0.628581384478089 0.6803563414748235 0.4962788578788983 1.0 0.9365903638742368 3 Q96EY1 1 +Glial cell differentiation 0.4117695404932689 0.6787015351046787 0.497326993306173 1.0 0.937261783556022 31 Q92542,P04062,P05067 3 +Embryo implantation 0.4381549334222142 0.6777141666458993 0.4979529423464808 1.0 0.9376329838439624 11 P35613,Q96GC9 2 +Protein localization to vacuole 0.4180268068574945 0.6773702816599507 0.4981710489979829 1.0 0.9376329838439624 15 Q14108 1 +Regulation of calcium ion dependent exocytosis 0.5610256422295494 0.6772709253093988 0.4982340745313069 1.0 0.9376329838439624 4 P04899,P16615 2 +Cell cell adhesion via plasma membrane adhesion molecules 0.5092362523257055 0.6757620494730535 0.4991917332685711 1.0 0.9389630608248108 7 Q14126,P35613,Q14574 3 +Roof of mouth development 0.5319700880649041 0.6750111171339505 0.4996687018727668 1.0 0.9391969128607116 5 O95470,Q9NWT1 2 +Lymphocyte activation involved in immune response 0.4079445806070298 0.6748740049335791 0.4997558173434648 1.0 0.9391969128607116 24 P02786,P11279,Q9UQ84 3 +Regulation of sodium ion transport 0.4224678418353345 0.6729422858378666 0.5009840088873247 1.0 0.9406292036587708 14 P27105 1 +Skeletal muscle cell differentiation 0.4900604090672663 0.6711441131332706 0.5021287271267858 1.0 0.941241297299798 8 P50402,Q9BYT8 2 +Mitochondrion distribution 0.5591616435348824 0.6700524336438237 0.5028243656785651 1.0 0.941241297299798 4 O75153 1 +Animal organ morphogenesis 0.3315005176949344 0.6676154333743748 0.5043791035818732 1.0 0.9415463849447012 75 Q8TAA9,O14786,P04062,P10253,O94813,Q9Y5P4,Q15555,Q92896,P35613,Q6P4Q7,O75844,P54802,P16435,O95140,O95470 15 +Negative regulation of mrna splicing via spliceosome 0.4266101767705327 0.667543942257657 0.5044247511588664 1.0 0.9415463849447012 13 Q07021,P22626,P26368,P38159 4 +Negative regulation of phosphatidylinositol 3 kinase signaling 0.5583101482731802 0.6667612005571244 0.5049246796715718 1.0 0.9420620484372808 4 O95630 1 +Positive regulation of monooxygenase activity 0.5297129056619634 0.6657741355453315 0.5055554792756116 1.0 0.9426739784276604 5 Q8WTV0 1 +Positive regulation of syncytium formation by plasma membrane fusion 0.5576915358026171 0.6643726042191335 0.5064518625026762 1.0 0.9429380160380114 4 Q14012,O75955 2 +Regulation of syncytium formation by plasma membrane fusion 0.5576915358026171 0.6643726042191335 0.5064518625026762 1.0 0.9429380160380114 4 Q14012,O75955 2 +Cation transmembrane transport 0.366032897577585 0.66374403745062 0.5068541488607361 1.0 0.9429380160380114 106 P12235,Q9UDW1,P05067,Q96ES6,P21796,P08195,Q9Y619,Q06787,P55011,P27105,P51790,Q00325,P61421,P16615,P35670,Q96GC9,O75964,P05026,P62942,P24539,Q15758,Q6P4Q7,O43772,Q70HW3,Q8TAD4,Q96NB2,Q13423,Q9HD20,Q9Y6M7 29 +3 phosphoadenosine 5 phosphosulfate metabolic process 0.5571832926341947 0.6624117460410625 0.5077073779358752 1.0 0.9429380160380114 4 Q8TB61 1 +Energy homeostasis 0.5233635487838294 0.6612948987116289 0.5084232123096055 1.0 0.9429380160380114 6 P42785 1 +Endosome organization 0.401493059445274 0.6580578998391344 0.5105009269342431 1.0 0.9438736309077684 20 Q14108,P51790 2 +Neuron development 0.4135717186111224 0.6563917324173141 0.511572108583427 1.0 0.9438736309077684 155 Q15375,O75503,O94813,Q9UL15,P30536,P50897,P05067,Q14012,Q96G23,P42892,P07196,Q14108,Q7L576,Q06787,O14786,Q9NQX7,P46108,Q16739,P54802,P04062,Q06481,Q9H4M9,Q9HCE1,P35613,Q32P28,O75955,Q9UQB8,O14949,Q15555,O00264,P53990,Q9NR77,Q9Y6M7,Q9NZJ7 34 +Stress activated protein kinase signaling cascade 0.4059266400412297 0.6511675387551135 0.5149383423852774 1.0 0.9440037768316772 26 O75844,P05067 2 +Tricarboxylic acid metabolic process 0.4857107956155242 0.6505793654810806 0.5153180540174476 1.0 0.9440037768316772 8 O75874,P48735 2 +Histone h3 acetylation 0.4507088240524373 0.649956745048982 0.5157201623117005 1.0 0.9440969510592904 10 Q14012,Q01658,Q03164 3 +Negative regulation of cell growth 0.4050031036806056 0.6495000879056348 0.5160151896460023 1.0 0.9443593682351588 25 P50897,Q15375 2 +Zinc ion homeostasis 0.5535079044602155 0.6482747938539746 0.516807233920201 1.0 0.945000798845024 4 Q8TAD4 1 +Fat soluble vitamin metabolic process 0.5246424931459487 0.6451146872463008 0.5188528666095391 1.0 0.946198889120212 5 Q99538 1 +Positive chemotaxis 0.5022242155446881 0.6444412203275023 0.5192893621714454 1.0 0.946198889120212 7 O14786,P14174,P26583 3 +Protein polyufmylation 0.6183263915183616 0.6434926870570388 0.5199044584292869 1.0 0.946198889120212 3 Q9Y3C8,Q96HY6 2 +Regulation of phospholipid metabolic process 0.449421358178742 0.6431119262148063 0.5201514764228259 1.0 0.946198889120212 10 Q8WTV0 1 +Regulation of actin cytoskeleton reorganization 0.4839186019449346 0.6421296176281684 0.5207890268641213 1.0 0.946198889120212 8 Q9UQB8 1 +Regulation of postsynapse organization 0.4121532599626494 0.6412021265505706 0.5213913681803748 1.0 0.946198889120212 15 Q9UQB8 1 +Positive regulation of smooth muscle cell proliferation 0.5012421970951949 0.6400715746590212 0.5221260680100956 1.0 0.946198889120212 7 O95140,P04899 2 +Neutrophil mediated immunity 0.6168793819042054 0.638341613273682 0.5232513291424494 1.0 0.946198889120212 3 P51809 1 +Cell cell adhesion 0.3352576178139059 0.6371797096508415 0.5240077926371489 1.0 0.9472635638388656 72 Q14126,O75955,Q15375,P61225,Q9UQB8,P02786,P10644,P35613,P04439,P78310,Q96GC9,Q9NUQ9,Q14574,O00592,Q9HCL2,Q14254 16 +Regulation of membrane potential 0.3874170204278683 0.6357949542069292 0.5249100766730854 1.0 0.9480048610693907 53 P05026,Q14126,Q9UQB8,P30536,P05067,O75844,Q06787 7 +Mast cell activation involved in immune response 0.5220505684902919 0.6346039954449927 0.5256867216802323 1.0 0.9480048610693907 5 P51809 1 +Mast cell activation 0.5220505684902919 0.6346039954449927 0.5256867216802323 1.0 0.9480048610693907 5 P51809 1 +Organic hydroxy compound transport 0.4020246460641367 0.634478483244922 0.5257686045918977 1.0 0.9480048610693907 24 Q8WTV0,P30536,P61916,P53985,Q9H2C2,O15118 6 +Metencephalon development 0.4040409921781793 0.6339343636269127 0.5261236582241915 1.0 0.9480938667996256 27 P04062,P46108,O14949,P54802,Q92542,Q5KU26 6 +Head morphogenesis 0.5216364140585472 0.6329277768171908 0.5267808077965519 1.0 0.9484304974965246 5 O75787 1 +Negative regulation of catabolic process 0.3446996378121698 0.6324772161350772 0.5270750917664593 1.0 0.9484304974965246 89 Q92530,Q14103,Q9NNW5,Q9UL15,P10619,P30536,O00560,O60506,Q14011,Q13151,Q16850,Q99729,P46379,O15118,P35637,Q9H2J4,Q92804,Q06787 18 +Histone h4 k16 acetylation 0.4992114451979748 0.6310491762942787 0.5280083708401575 1.0 0.9485295004367952 7 O75844,Q03164 2 +Actin mediated cell contraction 0.4151957597551686 0.6291208866547626 0.5292699173957418 1.0 0.9485295004367952 14 Q9UM22 1 +Dna methylation 0.4100547983001718 0.6283151886465222 0.5297974836396107 1.0 0.9485295004367952 15 O75844,Q8N2A8,Q8NB78 3 +Negative regulation of proteolysis 0.3687531866681877 0.6282007997846699 0.5298724064438121 1.0 0.9485295004367952 61 Q06481,P07858,Q9UL15,O00560,Q92896,Q15041,P05067,Q15392,P46379,P16435,Q9H2J4 11 +Myeloid cell activation involved in immune response 0.4807933400084967 0.6274295967427143 0.5303776721079192 1.0 0.9486157387371172 8 P09601,P51809 2 +Positive regulation of calcium ion transport 0.4194470556902594 0.6252777403473415 0.53178878683745 1.0 0.9492307875143244 13 P30536,Q96GC9 2 +Regulation of cardiac conduction 0.7180166540499583 0.6239992974117323 0.5326280464806608 1.0 0.9499675690624314 2 P16615 1 +Protein localization to endoplasmic reticulum 0.4036705637651254 0.6222943542687596 0.5337483328650188 1.0 0.9499675690624314 30 Q15005,Q7L5D6,Q9NQC3,P24390,P51572,O43681,Q15629,P46379,Q9Y5M8 9 +Insulin secretion involved in cellular response to glucose stimulus 0.5187431827250936 0.6212434813889435 0.5344394343898329 1.0 0.9499675690624314 5 O95563 1 +Regulation of insulin secretion involved in cellular response to glucose stimulus 0.5187431827250936 0.6212434813889435 0.5344394343898329 1.0 0.9499675690624314 5 O95563 1 +Positive regulation of cell junction assembly 0.4610292860547308 0.6199444250183918 0.5352943763534461 1.0 0.9499875830605302 9 O75955 1 +Glycerolipid biosynthetic process 0.4036220843606155 0.6185150022912392 0.5362359116434814 1.0 0.9499875830605302 33 P35790,Q92604,Q10713,Q96N66,Q8WTV0,O15228,Q8NCC3,Q6P1A2,Q9NPH0,Q9HCL2 10 +Myeloid leukocyte cytokine production 0.4956834544623433 0.6154202808626668 0.5382772012332642 1.0 0.9499875830605302 7 P09601,P14174,Q7Z434 3 +Camera type eye development 0.3982623830808411 0.6150110416155576 0.538547428525884 1.0 0.9499875830605302 23 O14786,Q15555,P54802,O95140,O75569,Q15293 6 +Negative regulation of cellular catabolic process 0.3328804371053632 0.6142124132265468 0.5390749716350496 1.0 0.9499875830605302 80 Q92530,Q14103,Q9NNW5,Q9UL15,P10619,P30536,O00560,O60506,Q14011,Q13151,Q99729,P46379,O15118,P35637,Q9H2J4,Q92804,Q06787 17 +Abscission 0.6099528717972127 0.6138669779839256 0.5393032330354233 1.0 0.9499875830605302 3 P53990 1 +Multicellular organismal homeostasis 0.3767455302154897 0.6127038309151241 0.5400721890113998 1.0 0.9499875830605302 57 P38571,P04062,P23786,Q06481,Q16836,Q15555,P02786,Q9UIQ6,P51790,O14773,Q13501,P42785,Q16625,Q16739,P78310,Q96H78,O43847 17 +Regulation of calcium ion transmembrane transporter activity 0.4219268267325449 0.6120014341653602 0.5405368086903499 1.0 0.9501307957346232 12 Q96GC9,Q06787 2 +Regulation of axonogenesis 0.3967297417318387 0.6114014990193374 0.540933810506462 1.0 0.9501307957346232 22 O14786,Q15375,O94813,P53990,P07196,Q8N0X7,Q7L576 7 +Isoprenoid metabolic process 0.3916269790568401 0.610134965192365 0.5417724063404274 1.0 0.9501307957346232 18 Q9HB40,P51648,P61916,P37268,Q8TC12,Q8NBN7,P48449 7 +Establishment of protein localization to endoplasmic reticulum 0.3940746570242576 0.6088628346403666 0.5426153604540889 1.0 0.9501307957346232 20 Q7L5D6,O43681,Q15629,P46379,Q9Y5M8 5 +Dicarboxylic acid metabolic process 0.4015504728491177 0.6078196440778497 0.543307099118362 1.0 0.950416053325666 37 P30520,Q9H2D1,O75874,P48735 4 +Negative regulation of nuclear transcribed mrna catabolic process deadenylation dependent decay 0.4763178982326994 0.6064600474169332 0.5442093048378702 1.0 0.9506306411563548 8 O60506 1 +Crd mediated mrna stabilization 0.4763178982326994 0.6064600474169332 0.5442093048378702 1.0 0.9506306411563548 8 O60506 1 +Maintenance of location 0.3802805039488924 0.6064350879769146 0.5442258744666701 1.0 0.9506306411563548 55 P10253,Q8WTV0,P24390,P30536,P07686,Q9H6V9,P17900 7 +Skeletal muscle adaptation 0.7127176381529104 0.6056780790707951 0.5447285431940327 1.0 0.9507933585438878 2 P16615 1 +Regulation of skeletal muscle adaptation 0.7127176381529104 0.6056780790707951 0.5447285431940327 1.0 0.9507933585438878 2 P16615 1 +Macromolecule deacylation 0.4014638469166606 0.6034128522768915 0.5462340743828968 1.0 0.9528869002824084 32 P50897,Q9NUJ1 2 +Myeloid cell differentiation 0.3686837060692868 0.6027556060707444 0.546671283685362 1.0 0.9531154892817316 60 O95628,P02786,P05067,Q15904,Q14739,O00115 6 +Sulfur compound biosynthetic process 0.3981401239908438 0.5974737373296825 0.550191136086732 1.0 0.9565491396034916 41 Q53GQ0,Q8TB61,Q13126,P50897,P11177,Q9UMR5,Q8NCH0,Q99735,Q9BV57,Q8N6G5,O43505 11 +Positive regulation of cell morphogenesis involved in differentiation 0.3945801625143474 0.5969967746285503 0.5505095340187098 1.0 0.9565491396034916 22 Q07021,O14786,Q9UQB8 3 +Negative regulation of fatty acid metabolic process 0.5121296513450653 0.5947094671107176 0.5520376925028496 1.0 0.9583251104889616 5 Q06481 1 +Fatty acid derivative metabolic process 0.3989994078716222 0.5911464169486893 0.554422321361117 1.0 0.9583251104889616 16 P50897 1 +Regulation of fatty acid biosynthetic process 0.5103055832527971 0.5874358442755394 0.5569110263207104 1.0 0.9601323668803844 5 O75477 1 +Positive regulation of endothelial cell migration 0.3894930942709733 0.5871590733389461 0.5570968762865762 1.0 0.9601323668803844 19 Q99538 1 +Striated muscle cell differentiation 0.3987240775568346 0.5865217924329922 0.5575249212866666 1.0 0.9601323668803844 37 Q99523,O75955,Q9H4M9,P10644,P78310,O75844,Q9H7B4,Q8IV08 8 +Positive regulation of chemokine c c motif ligand 5 production 0.7062831188493526 0.5837007327367782 0.5594216741932583 1.0 0.9610814965582852 2 Q7Z434 1 +Chemokine c c motif ligand 5 production 0.7062831188493526 0.5837007327367782 0.5594216741932583 1.0 0.9610814965582852 2 Q7Z434 1 +Tumor necrosis factor superfamily cytokine production 0.4025993790510691 0.5827026988485916 0.5600934560911608 1.0 0.9611832290599946 15 P05067 1 +Response to increased oxygen levels 0.4375564550863261 0.5804147081651359 0.5616349888845202 1.0 0.9627586566065592 10 Q8N511,Q9Y487 2 +Plasma membrane organization 0.3928583211958107 0.578575677752591 0.5628755201124029 1.0 0.9643541519592242 23 O75955,Q9UQB8,Q9H2C2,Q16739,Q96GC9 5 +Er associated misfolded protein catabolic process 0.5032826775812981 0.5772773587333071 0.5637521060229105 1.0 0.964362267653833 6 Q9BUN8 1 +Positive regulation of cytokine production involved in immune response 0.4523005820922602 0.5767071004330973 0.5641373350520364 1.0 0.964362267653833 9 P04439,Q7Z434 2 +Actin cytoskeleton reorganization 0.3913812183577749 0.5756012850892414 0.5648847122409535 1.0 0.964362267653833 22 P18031,P62993,Q13308,Q07157,O14786,P11233,Q9UQB8,P78310 8 +Immunoglobulin production involved in immunoglobulin mediated immune response 0.4104930522859846 0.5727964458354171 0.5667825258460379 1.0 0.964362267653833 13 P02786 1 +B cell activation involved in immune response 0.4104930522859846 0.5727964458354171 0.5667825258460379 1.0 0.964362267653833 13 P02786 1 +Somatic diversification of immunoglobulins involved in immune response 0.4104930522859846 0.5727964458354171 0.5667825258460379 1.0 0.964362267653833 13 P02786 1 +Negative regulation of rna splicing 0.400281738044655 0.5685840989018741 0.5696384183756926 1.0 0.9647150298345212 15 P38159,Q07021,Q9UKA9,P26368,P22626 5 +Regulation of cysteine type endopeptidase activity 0.3955459985168178 0.5683493619469232 0.5697977674099897 1.0 0.9647150298345212 39 O95831,Q9Y3D6,Q15375,Q15041,O14737,Q15392,Q99538,P16435,Q96A26,Q9NZJ7 10 +Ear development 0.3876338610271406 0.5663562675214103 0.5711516173560045 1.0 0.9655577811576352 20 O75569,Q9Y6M7,P54802,P42892 4 +Positive regulation of posttranscriptional gene silencing 0.4178985128335435 0.5633821470596541 0.5731746913581255 1.0 0.966783600145394 11 P51114,Q06787 2 +Postsynapse organization 0.3947018594643251 0.5615253561306982 0.5744394497741436 1.0 0.9672042374592128 29 Q99538,Q9UQB8 2 +Positive regulation of substrate adhesion dependent cell spreading 0.4130324409839925 0.5610400128712303 0.5747702603412561 1.0 0.9672042374592128 12 Q07021,O14786 2 +Cerebral cortex cell migration 0.4664939538422791 0.5607985866675259 0.5749348502974554 1.0 0.9672042374592128 8 O94813 1 +Intestinal epithelial cell differentiation 0.5940931465353951 0.5590424600153983 0.5761327426993517 1.0 0.9672042374592128 3 P04818,Q9NQ88 2 +Production of sirna involved in rna interference 0.5938633876426668 0.5582614346709197 0.5766658753300884 1.0 0.9672042374592128 3 O75569 1 +Lymphocyte apoptotic process 0.4169564965933114 0.5581197179942413 0.5767626369199741 1.0 0.9672042374592128 11 P24390,P14174,Q9HCL2 3 +Sensory perception of light stimulus 0.3980238434917157 0.5548601000131409 0.5789903551293631 1.0 0.9679279524513706 15 P50897,Q6P4Q7,Q9H6K4,Q15555 4 +Mitochondrial fragmentation involved in apoptotic process 0.5014665991067279 0.5524817844335856 0.5806183111050038 1.0 0.9687216985593564 5 Q9Y3D6 1 +Neurotransmitter uptake 0.527764246936518 0.5516081986024775 0.5812168180774553 1.0 0.969109777544252 4 O75955 1 +Calcium ion transport 0.3886155687287559 0.548698416819343 0.5832124328511528 1.0 0.969344857549514 45 P05026,P30536,P21796,O75844,P08195,P04899,Q96GC9,Q06787 8 +Peripheral nervous system development 0.4801822801664711 0.5475108839872063 0.5840277950546573 1.0 0.969344857549514 7 Q9NR77 1 +Mrna 5 splice site recognition 0.5001894657067119 0.547473159232123 0.5840537056352642 1.0 0.969344857549514 5 P09234,Q12872,O75475,Q07955 4 +Polyol metabolic process 0.3870169901574199 0.5465000433800217 0.5847222579101063 1.0 0.969344857549514 22 Q13510,P04062,Q10713,O15270,O15269,P35270 6 +Regulation of lymphocyte apoptotic process 0.4994707019741502 0.5446591626161933 0.5859879563923418 1.0 0.969344857549514 5 P14174,Q9HCL2 2 +Smad protein signal transduction 0.4790047922861671 0.54240802491262 0.5875374525976467 1.0 0.969344857549514 7 Q9UIQ6 1 +Regulation of t cell apoptotic process 0.5891568710435523 0.5423500232953602 0.587577401134149 1.0 0.969344857549514 3 Q9HCL2 1 +Transforming growth factor beta receptor signaling pathway 0.3826242498862502 0.5422552133056664 0.5876427040940122 1.0 0.969344857549514 19 Q92896,Q06481 2 +Positive regulation of locomotion 0.3366728730408418 0.5366432449644525 0.5915140665563001 1.0 0.9714444129075628 69 O14786,P46108,O94813,Q8WTV0,O00560,P05067,Q07021,Q99538,O00592,P04899,Q9H9T3 11 +Regulation of inflammatory response 0.3920926791601365 0.5359222654856615 0.5920122755773156 1.0 0.9714444129075628 32 P04062,P05067,P51809,Q99735,P53634,P28070 6 +Non canonical wnt signaling pathway 0.5225325469809421 0.5325264321094222 0.594361439950654 1.0 0.972796372155269 4 Q8TAA9 1 +Response to axon injury 0.4079355383174429 0.5320538359653431 0.5946887092747697 1.0 0.9728144781778024 12 P30536 1 +Regulation of cell cell adhesion 0.3917013045360635 0.531453813356593 0.5951043390527895 1.0 0.973238669541021 35 O75955,Q15375,P02786,P10644,P04439,Q9NUQ9,O00592,Q9HCL2,Q14254 9 +Regulation of t cell activation 0.3881200894192126 0.5286178318763988 0.5970705877211664 1.0 0.9750046470087904 26 O96005,P02786,P10644,P04439,Q9HCL2,Q14254 6 +Cellular response to xenobiotic stimulus 0.3788577790789521 0.5271640052159932 0.5980797023378104 1.0 0.9757977533425596 18 O43169 1 +T cell differentiation in thymus 0.4590904500189389 0.5267610190738428 0.5983595557875871 1.0 0.9759715699289446 8 P04062 1 +Protein import 0.3185805547884109 0.5265591705587094 0.5984997516846629 1.0 0.9759715699289446 74 Q15388,Q99595,O95831,O15397,Q06481,O60830,O43615,Q9NS69,O95373,Q7Z3B4,O14737,Q13501,Q7Z434,Q92973,O14925,Q99567 16 +Establishment of lymphocyte polarity 0.5207242695671863 0.5259798718181895 0.5989021921351199 1.0 0.9762748957946028 4 Q14254 1 +Retina development in camera type eye 0.3978508669239294 0.5256895657677477 0.5991039146938952 1.0 0.9762748957946028 14 O14786,P54802,Q15555 3 +Release of cytochrome c from mitochondria 0.4019102026095161 0.5229366904288657 0.6010183108188749 1.0 0.9774888798892502 13 Q9H3K2,Q9Y3D6,O00429,O14737,Q96A26 5 +Inorganic ion transmembrane transport 0.3464690861502726 0.5227370792999225 0.6011572311429392 1.0 0.9774888798892502 99 P12235,Q9UDW1,Q96ES6,P21796,Q9UBX3,P08195,Q06787,P51798,P55011,P27105,P51790,Q00325,P61421,P16615,P35670,Q96GC9,O75964,P05026,Q9UHG3,P24539,Q6P4Q7,Q8TAD4,Q13423,Q9HD20,Q9Y6M7 25 +Polysaccharide metabolic process 0.3828018078441667 0.5206822796735949 0.6025881207622346 1.0 0.9790484446413552 17 O43505 1 +Regulation of lipid transport 0.3862974988978875 0.5123882670720659 0.6083793008329503 1.0 0.97930433611424 16 P30536,O15260,Q9H2C2,Q6P1A2,Q9Y3D6 5 +Spindle midzone assembly 0.5166315903076673 0.5112587361695011 0.609169894906552 1.0 0.97930433611424 4 Q02241 1 +Regulation of lipid catabolic process 0.4870270342943694 0.5108358008535524 0.6094660381407193 1.0 0.97930433611424 6 Q8WTV0 1 +Early endosome to golgi transport 0.486602687817386 0.5091232379066871 0.6106658443477526 1.0 0.97930433611424 6 O15260 1 +T cell differentiation 0.3774845492272973 0.5088484061335441 0.6108584865392088 1.0 0.97930433611424 19 P24390,P04062 2 +Demethylation 0.3947244858923487 0.507249556567043 0.6119797274570169 1.0 0.97930433611424 14 Q16850,Q8NB78 2 +Er nucleus signaling pathway 0.3944829604092537 0.5058279871656055 0.612977409442423 1.0 0.97930433611424 14 O76024,P57088,O75477,P05198,Q6P1A2,P16615,Q96A33 7 +Gland development 0.3609012280038763 0.5051231050597307 0.6134723741346559 1.0 0.97930433611424 59 P11717,O14786,Q14103,P09601,P30536,P07602,Q99808,P25325,O75844,Q5T9L3,P35670,Q13505,Q9NZJ7 13 +Heterotypic cell cell adhesion 0.4702410218583486 0.5047047837915027 0.613766200593753 1.0 0.97930433611424 7 Q14126,O75955,Q14254 3 +Protein maturation by protein folding 0.485475524362962 0.5045800580767679 0.6138538192288368 1.0 0.97930433611424 6 P62942,O76024 2 +Bile acid biosynthetic process 0.4851308628701938 0.5031925459224765 0.6148289050514006 1.0 0.97930433611424 6 O14975,P22059 2 +Organelle fusion 0.3873541178981099 0.5019683241936064 0.6156898027251405 1.0 0.97930433611424 32 O15400,Q8N2A8,P02786,P51149,P51809,Q9Y3D6,O95140,Q13190,Q9UNK0 9 +Postsynaptic membrane organization 0.5140151515151618 0.5019188472247675 0.6157246070706859 1.0 0.97930433611424 4 O15258,P46109,Q96EY1 3 +Skeletal muscle organ development 0.3763546407648898 0.501529124224372 0.6159987861302674 1.0 0.97930433611424 19 P50402,Q9BYT8,O75955,P51114 4 +Purine ribonucleoside metabolic process 0.4694763248086495 0.50143910519334 0.6160621242016715 1.0 0.97930433611424 7 O60725 1 +Ribonucleoside metabolic process 0.4694763248086495 0.50143910519334 0.6160621242016715 1.0 0.97930433611424 7 O60725 1 +L serine catabolic process 0.6797880393641134 0.4966097397257876 0.6194642834950328 1.0 0.97930433611424 2 P34896 1 +Heart morphogenesis 0.3804954947483111 0.4958281273577956 0.6200156782231887 1.0 0.97930433611424 23 P10253,O75844,O94813,Q9Y5P4 4 +Phosphatidylcholine biosynthetic process 0.4829081005951795 0.4942636118942884 0.6211200200569023 1.0 0.97930433611424 6 P35790 1 +Regulation of lipid localization 0.377765525258015 0.49321021256237 0.6218640626008898 1.0 0.97930433611424 21 Q8WTV0,P30536,O15260,Q9H2C2,Q6P1A2,Q9Y3D6 6 +Lymphocyte activation 0.3203952862754443 0.4924888134648742 0.6223738281065319 1.0 0.97930433611424 78 Q96L92,P04062,P14174,P11279,O96005,P02786,P24390,P10644,P51809,P04439,P78310,Q9NUQ9,Q92542,Q9HCL2,P46379,Q9UQ84,Q14254 17 +Positive regulation of dna recombination 0.3749252315518224 0.492283430338601 0.622518992049234 1.0 0.97930433611424 19 P02786 1 +Cristae formation 0.4345973897274294 0.4904330635139249 0.6238274848993237 1.0 0.97930433611424 9 Q9NX63,Q9BUR5,Q6UXV4,Q5XKP0 4 +Forebrain cell migration 0.4345471429779228 0.4901912995863643 0.6239985368596512 1.0 0.97930433611424 9 O94813 1 +Small gtpase mediated signal transduction 0.3235034909485589 0.4884120643248001 0.6252579982010149 1.0 0.97930433611424 81 O14786,O75955,P62993,P11233,O94813,P61225,P46108,Q15555,O00560,O95630,P80303,O95140,Q15392,Q13501,Q9NUQ9,Q02818,Q7L576,Q9H0H5 18 +Cell migration involved in gastrulation 0.6767600302800859 0.4870331194174893 0.6262348606465844 1.0 0.97930433611424 2 Q4VCS5 1 +Positive regulation of b cell activation 0.4503076883250728 0.4868546550058435 0.6263613351430033 1.0 0.97930433611424 8 P02786,P14174 2 +Establishment of protein localization to plasma membrane 0.3765476971582995 0.4852334806954444 0.627510734968622 1.0 0.97930433611424 21 Q8N2H4 1 +Response to oxygen levels 0.3702529757009692 0.4835088310488805 0.6287344909108346 1.0 0.97930433611424 53 P05026,O95831,Q9NWT6,P30519,Q9Y487,P02786,O75306,Q8N511,P55786,Q9Y4P3,Q99808,P61421,Q96A26,Q15904,Q92544 15 +Lung alveolus development 0.6748675246025689 0.4810895103175696 0.6304528830080665 1.0 0.9794101905617516 2 Q15185 1 +Cerebral cortex development 0.3792438932889701 0.4805566204407346 0.6308316525763453 1.0 0.9794101905617516 24 Q96N66,P46108,O94813,Q96P11,Q96QD8 5 +Sulfur amino acid metabolic process 0.4322867386074914 0.4793353688075379 0.6317000644069133 1.0 0.9794101905617516 9 Q13126,P25325,Q9BV57 3 +Mitochondrial protein processing 0.4782888282218286 0.475817585285857 0.6342043405139883 1.0 0.9794101905617516 6 Q9UJZ1,Q10713 2 +Lipid biosynthetic process 0.3583356451466549 0.4757743659992698 0.6342351340434802 1.0 0.9794101905617516 114 Q13510,Q92604,O15270,Q9H7Z7,O15228,P30536,Q8NBQ5,Q16850,O75874,Q96G23,Q9HCL2,P35790,P14174,Q10713,O14975,O15269,O75845,O75477,Q14739,Q16739,Q9UKR5,Q6P1A2,P48449,Q9UBM7,O95470,P04062,Q96N66,Q8WTV0,Q8IVS2,P22059,Q8NCC3,Q15392,P37268,Q9H2C2,Q9UHQ9,Q9NPH0,Q8NBX0,Q53GQ0,Q14534,P05023,Q06136,P07686,P16435,Q15185 44 +Regulation of action potential 0.4172865884305928 0.4752884754970674 0.6345813722055984 1.0 0.9794101905617516 10 P78310,Q14126,P04062,Q06787 4 +Gastrulation with mouth forming second 0.5060606060606166 0.4738794461733766 0.6355858769814584 1.0 0.9799482119441476 4 Q99496,Q4VCS5,P35222 3 +Synaptonemal complex organization 0.480372472691748 0.4712613581028015 0.6374541067606478 1.0 0.98150873764309 5 P46379,Q92791 2 +Inositol lipid mediated signaling 0.4011496856046589 0.470746101549755 0.6378220583283012 1.0 0.9816215003258032 11 Q07021,O95630 2 +Aspartate transmembrane transport 0.6714610143830382 0.4704733045118436 0.6380169024701612 1.0 0.9816215003258032 2 Q9UJS0 1 +Positive regulation of neuron apoptotic process 0.4304197962034649 0.4703993314938929 0.6380697416990886 1.0 0.9816215003258032 9 Q15375 1 +3 utr mediated mrna stabilization 0.4767834926834167 0.4698394020003552 0.6384697612403585 1.0 0.981751724742522 6 Q13151 1 +Response to light intensity 0.6710825132475348 0.4693003275121951 0.6388549811893689 1.0 0.9821015093543236 2 Q8NBN7 1 +Mitotic spindle midzone assembly 0.5666157044763125 0.4686214619988624 0.639340233757357 1.0 0.9824659110284952 3 Q02241 1 +Cytokine production 0.3217233079814189 0.4671447378870825 0.6403963280518152 1.0 0.9830146791051778 81 P04062,O75955,Q06481,P01889,O75787,P30536,P05067,P04439,Q07021,Q9NUD5,Q8IV08 11 +Exocrine system development 0.502803181259035 0.4625577185608162 0.6436814213630682 1.0 0.9832091583430966 4 O14786 1 +Negative regulation of neuron apoptotic process 0.3790446223026703 0.4614476498726314 0.6444774717949702 1.0 0.9839423098076224 27 Q99538,P50897,O95630,P04062 4 +Negative regulation of endocytosis 0.428405657399201 0.4607903332285037 0.6449490378217748 1.0 0.9839702384176858 9 P05067 1 +Response to calcium ion 0.3712570378202235 0.4594401189516853 0.6459181439789723 1.0 0.9839702384176858 20 Q99538,Q14103,Q92542 3 +Regulation of macroautophagy 0.3791455081361153 0.4591943215016556 0.6460946279954163 1.0 0.9839983253178723 43 P12235,P04062,O15270,Q9Y487,O15269,P21796,P61421,O15118,Q93050 9 +Lamellipodium assembly 0.3697072802043379 0.458670939829183 0.6464704854764722 1.0 0.9840893013634514 19 Q16625,O94813,Q7L576 3 +Regulation of secretion 0.3140370146707562 0.4579017372103182 0.6470230387559643 1.0 0.9841166522282334 75 Q16836,P53985,Q16850,Q9BRT2,Q06787,P14174,P55011,O00429,P16615,Q99816,P11233,P22059,P09601,O00560,Q32P28,Q5T9L3,O00186,P11279,O95563,P00367,P51809,P40939,P51149,P04899 24 +Regulation of metal ion transport 0.3780837017298545 0.4567115477042202 0.6478783896099534 1.0 0.9841166522282334 44 P05026,P30536,P27105,P21796,Q96GC9,Q06787 6 +Spermatid differentiation 0.3813633614974705 0.454698880619751 0.6493258862984428 1.0 0.9841166522282334 15 Q8N2A8 1 +Histone h3 k14 acetylation 0.4996318724668611 0.4516284136654403 0.6515366971338039 1.0 0.9848609502982384 4 Q03164 1 +Response to steroid hormone 0.3483564936360807 0.451470393099378 0.6516505589306045 1.0 0.9848609502982384 62 P16278,O94813,P30536,O15173,O75874,O15118,Q9H7B4 7 +Response to cold 0.4262258521841936 0.4504289952467301 0.6524011417345998 1.0 0.9848609502982384 9 Q06481 1 +Response to ketone 0.3802978561139311 0.4478735260672297 0.6542444756476651 1.0 0.9848609502982384 35 O95831,P04062,Q14103,P16278,O94813,Q13126,P30536,P49321,Q9H7B4,P16435 10 +Positive regulation of peptidyl tyrosine phosphorylation 0.3844634829998054 0.4472705398112944 0.6546797352658886 1.0 0.9848609502982384 14 P14174,O14786,Q9H223,P22059 4 +Protein localization to extracellular region 0.3705498624229448 0.4471727108420039 0.6547503632045983 1.0 0.9848609502982384 50 Q16836,P22059,P55011,O00429,P00367,P53985,Q16850,Q96PC5,Q32P28,P40939,Q5T9L3,P20645,O95563,Q9BRT2,O00186 15 +Positive regulation of protein export from nucleus 0.4253309009675404 0.4461867132835075 0.6554623797227364 1.0 0.9848609502982384 9 P50402 1 +Response to nitric oxide 0.4410405214708913 0.4453715831925681 0.65605124464419 1.0 0.9848609502982384 8 Q14103,P46108 2 +Cellular response to reactive nitrogen species 0.4410405214708913 0.4453715831925681 0.65605124464419 1.0 0.9848609502982384 8 Q14103,P46108 2 +Regulation of establishment of planar polarity 0.4731741952493314 0.4443488016684111 0.6567904231899102 1.0 0.9848609502982384 5 Q8TAA9 1 +Necrotic cell death 0.3748273486431575 0.4422756218088544 0.6582897695265351 1.0 0.9848609502982384 16 Q13510,P30536,O00429 3 +Regulation of toll like receptor 9 signaling pathway 0.6619984859954526 0.4415544923784602 0.6588116208922672 1.0 0.9848609502982384 2 Q9NQC3 1 +Toll like receptor 9 signaling pathway 0.6619984859954526 0.4415544923784602 0.6588116208922672 1.0 0.9848609502982384 2 Q9NQC3 1 +Positive regulation of toll like receptor 9 signaling pathway 0.6619984859954526 0.4415544923784602 0.6588116208922672 1.0 0.9848609502982384 2 Q9NQC3 1 +Positive regulation of dendritic cell differentiation 0.6619984859954527 0.4415544923784602 0.6588116208922672 1.0 0.9848609502982384 2 P17931 1 +Cell projection assembly 0.3263346203507611 0.4411986564980286 0.6590691857639928 1.0 0.9848609502982384 87 O94813,Q7L576,Q06787,O14786,P53365,O00592,P51114,Q9H223,P11233,Q9H4M9,O00560,Q16625,Q9NQW6,Q9Y277,A0AVF1,P61225,Q15555,Q9NR77,P51116,A6NIH7 20 +Positive regulation of er associated ubiquitin dependent protein catabolic process 0.6612414837244458 0.4392781442793209 0.660460008585477 1.0 0.9851518958919931 2 P51572 1 +Cellular response to biotic stimulus 0.3774443640766021 0.4373789680552464 0.6618365343877244 1.0 0.9860242636329524 30 Q8WTV0,P30536,O75844,Q9NUQ9,Q96A33 5 +Histone arginine methylation 0.5558500567966655 0.4349867984996397 0.6635720098516731 1.0 0.9860242636329524 3 O14744,Q86X55 2 +T cell apoptotic process 0.4384009672392119 0.4336842977616333 0.6645177106574391 1.0 0.9860242636329524 8 P24390 1 +Endoplasmic reticulum membrane organization 0.4225619187982172 0.4331054632397804 0.6649381539913968 1.0 0.9860242636329524 9 Q6P1A2,Q9P2W9,Q15041 3 +Macroautophagy 0.3177070438194939 0.4328128835038931 0.6651507128756615 1.0 0.9860242636329524 80 P12235,P04062,Q99816,Q9Y487,O15270,P53365,O15269,P51809,Q13501,P21796,P61421,O15118,P16615,Q93050,O95140,Q96GC9 16 +Cellular process involved in reproduction in multicellular organism 0.3757929867343378 0.432773898172714 0.6651790377122997 1.0 0.9860242636329524 43 P53350,O60879,A0AVF1,O94813,Q8N2A8,Q01085,Q99496,P78310,Q9Y5A9,O95067,P07686,Q8NB78 12 +Intestinal epithelial cell development 0.6589704769114254 0.4324828587210252 0.6653905078548115 1.0 0.9860242636329524 2 P04818 1 +Post golgi vesicle mediated transport 0.3776929659499265 0.4311507178604233 0.666358784962505 1.0 0.9860242636329524 33 Q99523,Q8N2H4,P11279 3 +Viral life cycle 0.3174318626069769 0.4295241786413939 0.6675418019883936 1.0 0.9860242636329524 80 P11279,Q8WTV0,P07858,P02786,P27105,O15118,Q14108,Q06787 8 +Leukocyte proliferation 0.3756851569223427 0.4290690746124401 0.6678729570969018 1.0 0.9860242636329524 29 P04062,P02786,P04439,Q92542,Q9HCL2 5 +Negative regulation of endoplasmic reticulum unfolded protein response 0.4682732215120406 0.4262850981136579 0.6699001151519468 1.0 0.9860242636329524 5 O76024 1 +Biomineralization 0.4210465521628498 0.4259756367831475 0.6701255989351622 1.0 0.9860242636329524 9 O75844 1 +Positive regulation of erk1 and erk2 cascade 0.3798673906387039 0.4207083457785511 0.6739680661619047 1.0 0.9875279869145066 14 O14786,P04899,P05067 3 +Response to bacterium 0.3685211716547748 0.4193179638247668 0.674983769739451 1.0 0.9875279869145066 49 P14174,P01889,Q8WTV0,Q9UQB8,P30536,P04439,Q7Z434,Q9NUQ9,Q9BTY2,Q5KU26,Q9NZ08 11 +Positive regulation of apoptotic signaling pathway 0.3735654664410825 0.4190675424562106 0.6751667708710325 1.0 0.9875279869145066 28 Q9NQX7,O00429,P53634,P30154,Q9Y3D6 5 +Regulation of epithelial cell migration 0.3756396638537064 0.4140005831668679 0.6788736797477439 1.0 0.9888024031828804 35 P42785,Q99538,Q8WTV0 3 +Syncytium formation 0.462431289148459 0.4137204439317073 0.6790788530769687 1.0 0.9888024031828804 6 O75955,Q14012 2 +Autophagosome organization 0.3654048619632227 0.41282771465364 0.6797328445167601 1.0 0.9888024031828804 21 P04062,P53365,P16615,P51149,O95140,Q96GC9 6 +Response to metal ion 0.3664857512237861 0.4126347864783659 0.6798742106301838 1.0 0.9888024031828804 50 Q14103,P02786,P30536,P55011,Q8TAD4,P35613,P05198,P05067,P50995,P09960,Q99538,P36551,O15118,Q92542,P35670 15 +Regulation of cell projection assembly 0.3717573213675836 0.4125996358874136 0.6798999680722142 1.0 0.9888024031828804 45 O14786,P11233,O94813,Q16625,Q9NQW6,O00592,P51116,Q9Y277,P51114,Q06787 10 +Cardiac chamber development 0.378428183636674 0.4124334489569461 0.6800217506054209 1.0 0.9888024031828804 14 P62942,O14786,O75844,O94813 4 +Regulation of ras protein signal transduction 0.3699019941855743 0.4116188788196742 0.6806187919588407 1.0 0.9888024031828804 25 O14786,O75955,P46108,Q15555,O95630,Q13501 6 +Cellular response to carbohydrate stimulus 0.3605124843460896 0.410018794591173 0.6817921605749753 1.0 0.9888024031828804 18 P22059,Q99808,O95563,Q5KU26,Q12824 5 +Nadp metabolic process 0.3779070874229296 0.409442567736876 0.6822149061191909 1.0 0.9888024031828804 14 P48163,O75874,P48735 3 +Regulation of immune system process 0.3963990167317766 0.4092246613157251 0.682374797921605 1.0 0.9888024031828804 160 O15400,O94813,O43657,P05067,Q99538,Q8TCT8,O00115,Q9HCL2,Q9NZ08,O95628,P01889,P46108,P10644,O00429,P04439,Q9NPR9,Q06481,P53634,P28070,Q5KU26,O75955,P11279,O96005,P02786,P51809,Q07021,Q9NUD5,Q14254 28 +Synapse organization 0.3566916197372025 0.4087002612640491 0.6827596420307103 1.0 0.9888024031828804 56 O14786,Q15375,Q9UQB8,O00560,O00264,P05067,Q99538,Q14012,Q9BRK5,P07196 10 +Pyridine containing compound metabolic process 0.4466482299722237 0.4059928950305843 0.6847478208787856 1.0 0.9892710883122278 7 P43490 1 +Regulation of insulin secretion 0.3643808738284031 0.4058795645571233 0.684831093900691 1.0 0.9892710883122278 17 Q16836,P22059,P00367,P53985,O95563,Q9BRT2 6 +Response to camp 0.4162559152186869 0.4035765544447918 0.6865241294034492 1.0 0.9903380976983028 9 P05067 1 +Regulation of arp2 3 complex mediated actin nucleation 0.461750529328725 0.4025895000021094 0.6872502352857714 1.0 0.9904584541046092 5 Q7L576 1 +Ventricular cardiac muscle tissue development 0.4590476219708874 0.4007375099738153 0.6886133911415813 1.0 0.9904584541046092 6 O75844 1 +Negative regulation of translational initiation 0.4449359594115165 0.3990094507151632 0.689886240664187 1.0 0.9904584541046092 7 P05198,Q06787 2 +Regulation of phosphatidylinositol 3 kinase signaling 0.4446820838902631 0.397976311195791 0.6906476475169887 1.0 0.9904584541046092 7 O95630 1 +Regulation of protein targeting 0.3600454459795221 0.397082912443349 0.6913063202079002 1.0 0.9904584541046092 19 Q9Y3D6,P55786,P27105 3 +Cardiac muscle contraction 0.371484446388745 0.3964365661129237 0.6917829952296917 1.0 0.9904584541046092 15 Q14126,P10253 2 +Myeloid leukocyte mediated immunity 0.3795837320891982 0.3959476500042092 0.6921436479362724 1.0 0.9904584541046092 13 P09601,Q7Z434,O00186,P51809 4 +Hypothalamus development 0.4826202411920595 0.3946662171228488 0.6930892378434517 1.0 0.9904584541046092 4 O14786,O14949 2 +Regulation of growth 0.3343782517859953 0.3932022747335016 0.6941700897581384 1.0 0.9904584541046092 98 Q15375,O94813,P50897,P05067,Q99538,Q9HCL2,Q7L576,O14786,O75844,O95470,Q5BJF2,Q99816,O00560,O95067,Q96K76,Q8N0X7,O43598,P02786,P53990,Q99956 20 +Sno s rna processing 0.4290591805766317 0.3928201866309118 0.694452293964682 1.0 0.9904584541046092 8 Q9NQT5,O60832,Q5RKV6,P22087,Q01780,O95453,Q13868 7 +Homologous chromosome pairing at meiosis 0.4431629146537856 0.3918065737135224 0.6952011375197782 1.0 0.9904584541046092 7 Q9BTX1,Q92791 2 +Positive regulation of leukocyte cell cell adhesion 0.3588675063347722 0.3896392363003761 0.696803334344362 1.0 0.9904584541046092 19 P04439,P02786,Q9HCL2,Q14254 4 +Posttranslational protein targeting to endoplasmic reticulum membrane 0.4132314085259027 0.3895500809276007 0.6968692711806106 1.0 0.9904584541046092 9 P46379,O43681 2 +Regulation of cellular carbohydrate metabolic process 0.3642921612987118 0.3891255686473768 0.6971832600709165 1.0 0.9904584541046092 23 Q14108 1 +Mesenchymal stem cell differentiation 0.6434519303557853 0.3874463365642969 0.6984258056387047 1.0 0.9904584541046092 2 P49841 1 +Foregut morphogenesis 0.6434519303557851 0.3874463365642969 0.6984258056387047 1.0 0.9904584541046092 2 Q9HCM4 1 +Canonical wnt signaling pathway involved in osteoblast differentiation 0.6434519303557853 0.3874463365642969 0.6984258056387047 1.0 0.9904584541046092 2 P49841 1 +Neural plate development 0.6434519303557851 0.3874463365642969 0.6984258056387047 1.0 0.9904584541046092 2 Q9HCM4 1 +Regulation of neurogenesis 0.3621672310306434 0.3870177101170315 0.6987430968843968 1.0 0.9904584541046092 51 O14786,Q15375,O94813,Q06481,Q9UQB8,P30536,P53990,Q9Y5A9,Q96G23,P07196,P55209 11 +Regulation of protein autophosphorylation 0.4126327839434656 0.3867848261297653 0.6989155116101244 1.0 0.9904584541046092 9 Q15375 1 +Positive regulation of translation 0.3591184615453362 0.3854074483662074 0.6999355650181247 1.0 0.9904584541046092 53 Q14103,Q14011,Q07666,Q96P11,Q07021,Q9Y5A9,Q567V2,P51116,O60506,P51114,Q06787 11 +Organelle disassembly 0.3700431233917386 0.3833008713088712 0.7014966932917852 1.0 0.9904584541046092 42 P12235,P04062,P53365,P30536,O00429,Q13501,P21796,Q9Y3D6,O95140,Q8N5K1,Q13190 11 +Cation transport 0.3712056904400027 0.3830222661611224 0.7017032547092044 1.0 0.9904584541046092 135 P12235,P30536,Q9UDW1,P05067,Q96ES6,P21796,P08195,Q9Y619,Q06787,P55011,O00429,P27105,P51790,Q99808,Q00325,O75844,P61421,P16615,P35670,Q96GC9,O75964,P05026,P62942,P24539,Q15758,Q6P4Q7,O43772,Q70HW3,Q8TAD4,P02786,Q13423,O15173,Q9HD20,P51809,Q9Y6M7,Q96QD8,P04899 37 +Gamete generation 0.3247399959902227 0.3827015890663391 0.701941036093336 1.0 0.9904584541046092 90 O60879,P41208,Q99496,Q07666,Q9H2V7,P11717,P53350,Q8N2A8,Q08J23,P54619,Q9H8Y8,P46379,O95470,Q01085,Q9BTX1,O95067,O75718,A0AVF1,Q15067,P78310,P07686,Q9Y5A9,Q8NB78,Q9H0H5 24 +Autophagosome maturation 0.3809997095351899 0.3823314409171024 0.7022155364414715 1.0 0.9904584541046092 12 Q96GC9,P16615,P51809 3 +Indole containing compound metabolic process 0.6411809235427648 0.3810668202347392 0.7031536668593985 1.0 0.9904603461236684 2 Q92947 1 +Regulation of exit from mitosis 0.4554641266661752 0.3801451951587933 0.7038376386324192 1.0 0.9909753817560928 5 Q9NQW6 1 +Neuron projection arborization 0.4534001699610427 0.3792960310704489 0.7044680466077948 1.0 0.9913326135090016 6 O14786 1 +Aerobic respiration 0.3074454753688007 0.3787620168484251 0.7048645956052217 1.0 0.9913326135090016 75 O96000,Q9H3K2,P14406,P24539,O14949,Q9UDW1,P11177,O75306,O43676,Q13423,O75874,Q9BRT2,P48735,O75964 14 +Positive regulation of production of molecular mediator of immune response 0.358535666844976 0.3779477441114914 0.7054694137244351 1.0 0.9913326135090016 20 O96028,P14174,P02786,P04439,Q7Z434 5 +Positive regulation of cell adhesion 0.364562635768449 0.3769884822292332 0.7061821643762696 1.0 0.9913326135090016 48 O14786,O75955,P46108,P02786,P04439,Q07021,Q9NUQ9,O00592,Q9HCL2,Q14254 10 +Protein insertion into er membrane by stop transfer membrane anchor sequence 0.4771213232730402 0.3768923285528571 0.7062536226946188 1.0 0.9913326135090016 4 Q9NPA0 1 +Maintenance of protein localization in organelle 0.3758276799195607 0.3750604535381691 0.707615507251977 1.0 0.9914949934419858 13 P24390 1 +Midbrain development 0.354902749942674 0.3748400357504037 0.707779437264429 1.0 0.9914949934419858 18 Q5T9L3,P24539,O14949 3 +Rna polyadenylation 0.3661954220252322 0.3745344084016113 0.7080067620872552 1.0 0.9914949934419858 27 P05067 1 +Rna secondary structure unwinding 0.475378787878795 0.3713288460433426 0.7103926153374085 1.0 0.9923710465778828 4 O00571,Q13838,Q9H2U1 3 +Negative regulation of lipid biosynthetic process 0.4506693401213809 0.3690339620638924 0.7121024105603078 1.0 0.9923710465778828 6 O75477 1 +Cellular response to acid chemical 0.3743317543452786 0.366786287419187 0.7137784369137663 1.0 0.9926994936453588 13 Q99729,Q9UQB8 2 +Aspartate family amino acid metabolic process 0.3577006052369313 0.3650672358873293 0.7150612174900006 1.0 0.9933486486445536 17 P30520,Q13126 2 +Positive regulation of cell migration involved in sprouting angiogenesis 0.4732020637865428 0.3644266111639845 0.7155394668661592 1.0 0.9933826942411964 4 O14786 1 +Regulation of cell migration involved in sprouting angiogenesis 0.4732020637865428 0.3644266111639845 0.7155394668661592 1.0 0.9933826942411964 4 O14786 1 +Positive regulation of cell activation 0.3685341272267705 0.3641106520540097 0.7157753828243307 1.0 0.9934056026447354 34 P11279,P02786,P51809,P04439,P53634,Q9HCL2,Q14254 7 +Positive regulation of cell substrate junction organization 0.4219064469638885 0.3620993619347321 0.7172777804431196 1.0 0.994742992134581 8 O14786 1 +Negative regulation of hydrolase activity 0.3495636999264289 0.3602224271570181 0.7186808044789128 1.0 0.994742992134581 57 Q06481,Q15392,P07858,P05067 4 +N terminal protein amino acid modification 0.4482153764747415 0.3598732882601526 0.7189418934517502 1.0 0.994742992134581 6 Q86UY6 1 +Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress 0.3730642932302689 0.3597963836298748 0.7189994077843262 1.0 0.994742992134581 13 O76024,O95831,P46379,O95881 4 +B cell mediated immunity 0.3651668212896956 0.3597203997706352 0.7190562350668341 1.0 0.994742992134581 15 P02786,Q9UQ84 2 +Lactation 0.3804445830197527 0.359634523501557 0.7191204626162655 1.0 0.994742992134581 11 Q13505,P52789,Q99808,P35670 4 +Cardiac ventricle development 0.3767011349335493 0.3591054085169275 0.7195162356981424 1.0 0.994742992134581 12 O75844 1 +Protein deglycosylation 0.449119592620244 0.3579058493839357 0.7204137731344082 1.0 0.994742992134581 5 O00754 1 +Germ cell development 0.3664234990803806 0.3573209394954804 0.7208515558759858 1.0 0.9950425034379472 31 A0AVF1,Q01085,Q8N2A8,Q9Y5A9,P07686 5 +Branching morphogenesis of an epithelial tube 0.4050874602595425 0.3522549852576773 0.7246470438342771 1.0 0.9979084314135152 9 O94813 1 +Positive regulation of viral life cycle 0.4453357133950861 0.3491989279308152 0.7269399709938869 1.0 0.9998621907526716 6 Q06787 1 +Rna phosphodiester bond hydrolysis endonucleolytic 0.3636926484295081 0.3470853098105338 0.7285272293828013 1.0 1.0 29 O00584,Q9UQ84 2 +Synaptic signaling 0.3164600151612671 0.3464973611641527 0.7289689670211739 1.0 1.0 70 O75955,Q9UQB8,P50897,O00560,P51790,P05067,Q13501,Q99538,Q9NR77,Q92542,Q06787 11 +Positive regulation of response to endoplasmic reticulum stress 0.4440079623645089 0.3443052129527499 0.7306167643238168 1.0 1.0 6 P46379,P57088,P51572 3 +Snorna localization 0.4666666666666766 0.3440275127175928 0.7308255953928486 1.0 1.0 4 Q8WWY3,Q9NWS0,P22087 3 +Regulation of cell morphogenesis involved in differentiation 0.3596242080757625 0.343847524676497 0.7309609573761917 1.0 1.0 25 Q07021,O14786,Q9UQB8 3 +Rrna 3 end processing 0.4435178165276737 0.3425032038997388 0.7319722332776817 1.0 1.0 6 Q9NQT5,Q15024,Q01780,Q13868,P63220 5 +Leukocyte homeostasis 0.3903841607816967 0.3411659364012515 0.7329786653719692 1.0 1.0 10 P14174,O95067,Q9HCL2,Q96EY1 4 +Muscle cell differentiation 0.3492007192234144 0.3405107635413738 0.7334719184327267 1.0 1.0 56 Q99523,O75955,Q9H4M9,P10644,P78310,Q9BYT8,Q14012,O75844,Q9H7B4,Q8IV08 10 +Protein localization to phagophore assembly site 0.4646953117712254 0.3379718836440947 0.7353843759443235 1.0 1.0 4 O95140 1 +Negative regulation of immune response 0.3529918407096404 0.333654378628841 0.7386403791131584 1.0 1.0 21 P46108,P01889,P09601,P04439,Q9Y5A9,P28070 6 +Cell chemotaxis 0.3642575701018317 0.3320832052122777 0.7398264315097594 1.0 1.0 35 O14786,P14174,P46108,O94813,O00429,P35613,P78310,Q99538,Q07021 9 +Ubiquinone metabolic process 0.4627150158490506 0.3319353056430955 0.7399381103250082 1.0 1.0 4 Q9NZJ6 1 +Regulation of neurotransmitter transport 0.3715976863104265 0.3318194934978408 0.7400255637865367 1.0 1.0 12 O75955,P16615,Q06787 3 +Antiviral innate immune response 0.4406972338006858 0.3290603504572685 0.742110072571474 1.0 1.0 5 Q92667,Q9H078,P35232,Q9NVI7 4 +Export from cell 0.3466894210914508 0.3284113148782471 0.7426006889639369 1.0 1.0 115 Q7Z7E8,Q16836,P50897,P53985,Q16850,Q9BRK5,P08183,Q9BRT2,Q06787,P14174,P55011,O00429,Q96PC5,P16615,P20645,P35670,P05026,Q99816,P11233,P22059,P09601,O00560,O43760,Q15758,Q32P28,Q5T9L3,O00186,P11279,P05023,P00367,P51149,P51809,P40939,O95563,P04899 35 +N glycan processing 0.5179856115107898 0.3260540116890696 0.7443834906036695 1.0 1.0 3 Q16706,Q14697 2 +Valine metabolic process 0.4606060606060721 0.325558406003284 0.7447584862505425 1.0 1.0 4 Q6NVY1,Q02252,A1L0T0 3 +Response to ischemia 0.386910728335833 0.3244225009122958 0.7456181869037408 1.0 1.0 10 Q13501,O95831 2 +Positive regulation of nucleobase containing compound transport 0.5173122390716625 0.3242605986242491 0.7457407471749646 1.0 1.0 3 Q07666 1 +Positive regulation of rna export from nucleus 0.5173122390716625 0.3242605986242491 0.7457407471749646 1.0 1.0 3 Q07666 1 +Respiratory electron transport chain 0.3617612491239877 0.3232146691592456 0.7465326722523096 1.0 1.0 43 O96000,Q9H3K2,P04062,O75208,O14949,O43819,Q9UDW1,O43674,O75306,O43676,P20674 11 +Oocyte differentiation 0.3863532777559749 0.3217493297758519 0.7476426035549113 1.0 1.0 10 Q8N2A8 1 +Response to activity 0.3658532729698294 0.3204075565215237 0.7486593979819678 1.0 1.0 13 Q15388,Q16836,O43819,P40939,P48506 5 +Regulation of innate immune response 0.36079883774136 0.3201081448852581 0.7488863515465054 1.0 1.0 44 Q06481,P46108,P01889,P11279,Q96PK6,P04439,Q9Y5A9,Q9NUD5,Q9NZ08 9 +Negative regulation of ire1 mediated unfolded protein response 0.6180923542770562 0.3194538510650387 0.7493823809493847 1.0 1.0 2 Q96HY6 1 +Regulation of sterol transport 0.4108641882639979 0.3157458419701198 0.752195428410652 1.0 1.0 8 P30536,Q9H2C2 2 +Negative regulation of lipid metabolic process 0.3968677611866382 0.3153709700807186 0.7524800055701302 1.0 1.0 9 Q06481 1 +Response to misfolded protein 0.4103216936430131 0.3135044263712493 0.7538974583169473 1.0 1.0 8 Q9BUN8 1 +Histone lysine demethylation 0.4356205116715674 0.3120656579189332 0.7549906251490934 1.0 1.0 5 Q8NB78 1 +Regulation of cell shape 0.3546387105172032 0.3114192918325655 0.7554818898001401 1.0 1.0 25 O75844,Q9UQB8 2 +Cell morphogenesis involved in neuron differentiation 0.303573586132077 0.3049487098515916 0.7604052163718917 1.0 1.0 77 O75955,Q15375,Q06481,Q9UQB8,O94813,P35613,P05067,P42892 8 +Positive regulation of neurogenesis 0.3604915442529502 0.303262759881975 0.7616896239405992 1.0 1.0 37 O14786,O94813,Q9UQB8,P30536,P53990,P07196,P55209 7 +Positive regulation of nervous system development 0.3604915442529502 0.303262759881975 0.7616896239405992 1.0 1.0 37 O14786,O94813,Q9UQB8,P30536,P53990,P07196,P55209 7 +Positive regulation of myeloid leukocyte cytokine production involved in immune response 0.4315697553818968 0.2993631776797589 0.764662954540029 1.0 1.0 6 P14174,Q7Z434 2 +Diencephalon development 0.4317109639101895 0.2991880021406769 0.7647966031789297 1.0 1.0 5 O14786,O14949 2 +Signal release 0.3579912932054513 0.2982012226188363 0.7655495887058241 1.0 1.0 44 Q7Z7E8,P14174,Q16836,P22059,P50897,O00186,P00367,P53985,P51809,P40939,P16615,Q5T9L3,O95563,Q9BRT2,Q06787 15 +Viral protein processing 0.4182783466059717 0.2940843780007751 0.7686934278942765 1.0 1.0 7 Q10472,P49841,P48729,P27824,Q99873,Q16706 6 +Ectoderm development 0.5054903445664489 0.2936574814741407 0.7690196473187725 1.0 1.0 3 P35222,Q9HCM4 2 +Mesoderm morphogenesis 0.4299388833488011 0.2935967170900704 0.76906608466632 1.0 1.0 6 P10644 1 +Nucleoside bisphosphate biosynthetic process 0.3524473092725446 0.2901687109391379 0.771687171975326 1.0 1.0 26 Q53GQ0,Q8TB61,P50897,P11177,Q9UMR5 5 +Regulation of protein maturation 0.4172419185761453 0.290163641883275 0.771691049763847 1.0 1.0 7 Q92896 1 +Polyadenylation dependent snorna 3 end processing 0.4287338893100756 0.2893556885480379 0.7723092006586985 1.0 1.0 6 Q9NQT5,Q5RKV6,Q01780,O95453,Q13868 5 +U4 snrna 3 end processing 0.4285714285714346 0.2889826502832426 0.7725946544712872 1.0 1.0 5 Q13868,Q5RKV6,Q9NQT5,Q15024 4 +Negative regulation of cell population proliferation 0.3067624566693176 0.288841731827483 0.7727024951471764 1.0 1.0 81 Q99816,Q06481,Q01085,Q9NNW5,Q96DY7,P50402,P30536,P10644,P09601,O14737,Q15392,P05067,Q32P28,Q9NR77,Q96G23,O95140,O75569 17 +Vascular endothelial cell proliferation 0.5032184778492944 0.2879712921150776 0.7733687138244252 1.0 1.0 3 P09429,P19174 2 +Positive regulation of vascular endothelial cell proliferation 0.5032184778492944 0.2879712921150776 0.7733687138244252 1.0 1.0 3 P09429,P19174 2 +Homologous chromosome segregation 0.404061912839912 0.2878995044792675 0.7734236662328011 1.0 1.0 8 Q9BTX1,Q92791 2 +Coenzyme a biosynthetic process 0.4477272727272839 0.287814999528212 0.7734883550194402 1.0 1.0 4 Q8WVC6,O00154,Q9NVE7 3 +Protein localization to cilium 0.3660114412620429 0.2851214915467189 0.7755510652590689 1.0 1.0 11 A0AVF1,Q10713 2 +Hepaticobiliary system development 0.3526788374449265 0.2850506784325569 0.7756053159550271 1.0 1.0 27 P11717 1 +Regulation of osteoblast differentiation 0.4267306956461133 0.282342716452761 0.7776807343579666 1.0 1.0 6 Q9H6W3,Q9NR12 2 +Localization within membrane 0.3743913432463177 0.2803697155415662 0.7791938691600524 1.0 1.0 148 Q96L92,O15400,P07602,O14737,Q13501,P43307,Q92544,Q9H8Y8,P27105,Q15041,Q8N2H4,Q9Y3D6,P46379,Q9UNK0,P05026,Q9H223,P11233,Q9NS69,Q9H4M9,O00560,P35613,O43681,O60725,Q9BTX1,Q15629,Q96A33,O75955,Q9HD20,O00264,O15118,Q15904,Q9NZJ7,Q14254,Q9HD45 34 +Regulation of animal organ morphogenesis 0.4139184630994235 0.2776792644849402 0.781258579395641 1.0 1.0 7 Q8TAA9 1 +Endoplasmic reticulum localization 0.6006813020438991 0.277107538581159 0.7816975334608385 1.0 1.0 2 Q9BSJ8 1 +Endoplasmic reticulum plasma membrane tethering 0.6006813020438991 0.277107538581159 0.7816975334608385 1.0 1.0 2 Q9BSJ8 1 +Negative regulation of inflammatory response 0.3576921217033789 0.276676345241237 0.7820286368367271 1.0 1.0 13 P28070,P04062 2 +Negative regulation of transport 0.3260747835123544 0.2765148753734133 0.7821526359765716 1.0 1.0 64 Q06481,O00560,P05067,Q16850,P21796,Q9Y3D6,P04899,Q06787 8 +Regulation of fatty acid metabolic process 0.3760135433272058 0.272911398813311 0.784921324037803 1.0 1.0 10 Q06481 1 +Nuclear pore organization 0.3634636740172829 0.2722681794961519 0.7854158213843574 1.0 1.0 11 Q9BTX1,Q7Z3B4 2 +Regulation of substrate adhesion dependent cell spreading 0.3496751469527699 0.2718461153597865 0.7857403450227722 1.0 1.0 15 Q07021,O14786 2 +Skin development 0.3543096959633177 0.2704576227768129 0.7868082145749025 1.0 1.0 32 Q13510,Q16739,O75844,Q15392 4 +Regulation of long chain fatty acid import across plasma membrane 0.5976532929598717 0.2701204754634734 0.7870675702867704 1.0 1.0 2 P31751 1 +Long chain fatty acid import across plasma membrane 0.5976532929598717 0.2701204754634734 0.7870675702867704 1.0 1.0 2 P31751 1 +Morphogenesis of a branching structure 0.3564172403039838 0.269933099338883 0.7872117224414223 1.0 1.0 13 O14786,Q15375,O94813 3 +Lymphocyte homeostasis 0.411651308611914 0.2692413275361449 0.7877439792695262 1.0 1.0 7 P14174,O95067,Q9HCL2 3 +Response to inorganic substance 0.3147167854704899 0.2644578310059006 0.7914271543862401 1.0 1.0 90 O95831,P30536,P05067,Q99538,P09960,P07196,Q06787,P46108,P55011,P36551,P35670,P30520,Q14103,P35613,P05198,Q8TAD4,P02786,P50995,Q99720,O15118,Q96QD8,Q92542 22 +Cellular response to muramyl dipeptide 0.5946252838758443 0.2632474334855957 0.7923598730337773 1.0 1.0 2 P08670 1 +Protein peptidyl prolyl isomerization 0.3382769147157588 0.2623453236980368 0.7930552220324161 1.0 1.0 19 Q9Y680 1 +Regulation of programmed necrotic cell death 0.4096559999389525 0.2618689860549689 0.793422450982296 1.0 1.0 7 Q13510 1 +Positive regulation of protein dephosphorylation 0.3548707809764433 0.2617870637028873 0.7934856130270214 1.0 1.0 13 Q86XL3 1 +Retinol metabolic process 0.4198802521292681 0.2613854113613554 0.7937953061414342 1.0 1.0 5 Q8TC12,Q8NBN7 2 +Lipid translocation 0.4914747354941221 0.2596109290374201 0.7951639051684785 1.0 1.0 3 Q96GC9 1 +Negative regulation of calcium mediated signaling 0.491101855357819 0.2587392228736534 0.7958364542932446 1.0 1.0 3 P49841,Q9UHD1 2 +Negative regulation of calcineurin mediated signaling 0.491101855357819 0.2587392228736534 0.7958364542932446 1.0 1.0 3 P49841,Q9UHD1 2 +Positive regulation of calcium ion transmembrane transporter activity 0.4198344794234014 0.2585661029325585 0.795970039924065 1.0 1.0 6 Q96GC9 1 +Toxin transport 0.3566832220042626 0.2541084277052245 0.7994117926592506 1.0 1.0 12 Q93050 1 +Somatic diversification of immunoglobulins 0.3389410360355542 0.2535523554360317 0.7998414087371728 1.0 1.0 17 P02786 1 +Protein demethylation 0.417964872624441 0.2522206660338421 0.8008705051497995 1.0 1.0 6 Q8NB78 1 +Central nervous system neuron development 0.3712711338033067 0.2510150967033394 0.8018024373069783 1.0 1.0 10 O94813,O14949 2 +Positive regulation of g protein coupled receptor signaling pathway 0.5885692657077897 0.2498462749758711 0.80270623204926 1.0 1.0 2 P35232 1 +Golgi ribbon formation 0.5885692657077897 0.2498462749758711 0.80270623204926 1.0 1.0 2 Q9Y3A6 1 +Pallium development 0.3511188727310828 0.2487842015698312 0.8035277122856535 1.0 1.0 32 Q96N66,O94813,O14949,Q96P11,Q96QD8 5 +Mitochondrion localization 0.3483493177720642 0.2452585434676651 0.8062562490896434 1.0 1.0 14 O75153,O00429,O95140 3 +Ubiquitin dependent erad pathway 0.3483864405471129 0.2449503870266038 0.8064948466115751 1.0 1.0 29 Q9UBU6,P46379,O75477,Q9BUN8 4 +Pigment granule localization 0.4846648996592206 0.2439752178198675 0.8072500133576006 1.0 1.0 3 P62820,Q13561 2 +Oxidative phosphorylation 0.3451334367736635 0.24264325564741 0.8082817692060695 1.0 1.0 51 O96000,Q9H3K2,O75208,P24539,O14949,O43674,Q9UDW1,P14406,O75306,P00403,O43676,P20674,Q9UJZ1,Q9BRT2,O75964 15 +Substrate adhesion dependent cell spreading 0.3405902469946391 0.2415657748075244 0.809116644481942 1.0 1.0 16 Q07021,O14786 2 +Regulation of peptide transport 0.3330175673415069 0.2415166389782193 0.8091547220772579 1.0 1.0 18 Q16836,P22059,P00367,P53985,O95563,Q9BRT2 6 +Regulation of glycogen catabolic process 0.5836487509462454 0.2392993717230179 0.8108734525504717 1.0 1.0 2 P62140 1 +Terpenoid metabolic process 0.347184178322635 0.2390457437166575 0.8110701123913608 1.0 1.0 14 Q9HB40,P51648,P37268,Q8TC12,Q8NBN7,P48449 6 +Positive regulation of protein k63 linked ubiquitination 0.5832702498107418 0.2385008327155517 0.8114926695712732 1.0 1.0 2 O00571 1 +Skeletal system development 0.3511556107435656 0.2372468031751759 0.8124653288907604 1.0 1.0 41 Q92896,Q32P28,P07686,O75844,P16435,Q15904,O95470 7 +Negative regulation of autophagosome assembly 0.5813777441332247 0.2345355773701426 0.814569216530947 1.0 1.0 2 O75396 1 +Icosanoid biosynthetic process 0.3902451764927818 0.2331859929431571 0.8156169820876069 1.0 1.0 8 O14880,P14174,Q9H7Z7,Q99735,P09960 5 +Positive regulation of dephosphorylation 0.3459411053057019 0.2324426032076587 0.8161942623241234 1.0 1.0 14 Q86XL3 1 +Sulfur compound metabolic process 0.3108705026307437 0.2321817677400682 0.8163968380932485 1.0 1.0 89 Q8TB61,Q9H7Z7,Q13126,P50897,Q9UMR5,P11177,P15586,O75874,Q9UBX3,Q9HCL2,P16278,Q99735,Q9BV57,O60725,Q9Y305,Q8N6G5,O43505,Q53GQ0,Q8NCH0 19 +Regulation of hormone secretion 0.3365548224859749 0.2319764786124911 0.816556282872374 1.0 1.0 21 Q16836,P22059,P00367,P53985,P51809,O95563,Q9BRT2 7 +Regulation of mrna splicing via spliceosome 0.3400610515209757 0.2315901846893882 0.8168563317610325 1.0 1.0 54 Q07666,P09651,P22626,Q06787,P62995,P52756,Q96EP5,P26368,P17844,P61978,Q9UHX1,P51114,Q15007,Q92841,Q14011,P38159,Q9Y2W1,Q13595,P98179,Q8IY67,Q01130,Q07021,P51116,Q9BWF3 24 +Ameboidal type cell migration 0.3334681060732032 0.2287242544590708 0.8190832421200809 1.0 1.0 58 O14786,Q06481,O94813,Q8WTV0,Q07021,Q99538,P42785,Q9NQW6,O95470 9 +G protein coupled receptor signaling pathway 0.3497921955347748 0.228156366512338 0.8195246813073038 1.0 1.0 36 Q99523,P11717,Q06481,P07602,P42892 5 +Pigmentation 0.350933222694741 0.2250588657421402 0.8219334804576153 1.0 1.0 12 O75787 1 +Female gamete generation 0.3369185711998561 0.2247928161754898 0.8221404549291629 1.0 1.0 22 P53350,O60879,Q8N2A8,Q9Y5A9,O95067,P07686,O95453 7 +Nuclear membrane reassembly 0.3754543399949447 0.2234180429467912 0.8232101629609125 1.0 1.0 9 Q86XL3 1 +Regulation of receptor binding 0.4738147399827457 0.2203217638024322 0.825620571508898 1.0 1.0 3 O14786 1 +Histone phosphorylation 0.3366962175037169 0.2198205653929302 0.826010902482033 1.0 1.0 16 O75844 1 +Adenylate cyclase modulating g protein coupled receptor signaling pathway 0.3497440102889191 0.2191203533161915 0.8265562963584046 1.0 1.0 12 P04899,P07602 2 +Negative regulation of mrna processing 0.3328530467565601 0.2185380473851794 0.8270099171048693 1.0 1.0 17 Q07021,P22626,P26368,P38159 4 +Positive regulation of lipid storage 0.4216112026415364 0.2180488308073485 0.8273910651676875 1.0 1.0 4 Q8WTV0 1 +Tetrapyrrole biosynthetic process 0.3637007602315592 0.2167777283455168 0.8283815694596137 1.0 1.0 10 P30536,O00264 2 +Mitochondrial translational elongation 0.4208333333333433 0.2161180673139829 0.828895716810033 1.0 1.0 4 Q96RP9,Q9H9J2,P43897 3 +Phosphatidylinositol acyl chain remodeling 0.4717305730556475 0.2159578345866081 0.8290206151033583 1.0 1.0 3 Q96N66 1 +Epithelial cell differentiation 0.3070212619116083 0.2128568853523225 0.8314385921908451 1.0 1.0 87 Q13510,P61225,P07858,P31942,P07602,P09960,Q16739,P21796,Q9Y6M7,O00592,O14773 11 +Brown fat cell differentiation 0.4193181818181851 0.2123825859939888 0.8318085702641038 1.0 1.0 4 Q96HE7,Q02252,Q9C0B1 3 +Protein folding in endoplasmic reticulum 0.3722960151802723 0.2104228230577712 0.8333376811677338 1.0 1.0 9 Q9P0L0,Q13217,P27824,P30101,P07237,Q8IXB1,P14625,Q96HE7 8 +Regulation of myoblast fusion 0.4688119209135215 0.2099447801044659 0.8337107715164067 1.0 1.0 3 O75955 1 +Positive regulation of myoblast fusion 0.4688119209135215 0.2099447801044659 0.8337107715164067 1.0 1.0 3 O75955 1 +Regulation of production of molecular mediator of immune response 0.3358172392551598 0.2090829278527266 0.8343835017748011 1.0 1.0 23 O96028,P14174,P09601,P02786,P04439,Q7Z434 6 +Mitochondrial protein catabolic process 0.5685087055261117 0.208791687695344 0.8346108605903158 1.0 1.0 2 Q9UG56 1 +Peroxisomal transport 0.4177995396302721 0.2086721886450098 0.8347041524224703 1.0 1.0 4 P28288,O75381 2 +Striated muscle contraction 0.3308703881252286 0.2072780653478579 0.8357927034725154 1.0 1.0 17 Q14126,P10253 2 +Biological process involved in interaction with symbiont 0.3354290847782261 0.2067160884139657 0.8362315920390131 1.0 1.0 23 P11717,P27105 2 +Negative regulation of jun kinase activity 0.5654806964420842 0.2030450018246036 0.8390998583721649 1.0 1.0 2 P31689 1 +Organic hydroxy compound catabolic process 0.3493467918860456 0.202917999905721 0.8391991250652304 1.0 1.0 11 Q10713,Q8WTV0 2 +Divalent inorganic cation homeostasis 0.3453610796269394 0.2009595946295374 0.8407301683103618 1.0 1.0 44 P05026,O76024,P62942,Q8TAD4,P51572,Q96A33,Q9HD20,P05067,Q6P4Q7,P07686,P16615,Q9UJZ1,Q9Y3D6,P35670 14 +Lipid metabolic process 0.4310635340281094 0.1996723716064693 0.8417368228915842 1.0 1.0 230 Q8NHP8,Q13510,Q86UY6,Q16836,Q9HB40,Q9H7Z7,P30536,P50897,Q9BQE5,P06280,Q8NBQ5,P07602,P05067,Q16850,Q99538,P53985,O75874,P09960,Q96G23,Q9H6V9,Q9HCL2,P06865,P35790,Q10713,P16278,Q8N2A8,O14975,P46108,P21964,P61916,O15269,O75845,O75477,Q14739,Q99735,Q16739,O75844,Q9UKR5,Q6P1A2,Q8N4Q0,Q9BWD1,Q9UBM7,O14773,P48449,O95470,P04062,Q06481,Q96N66,Q8WTV0,Q8NCC3,O43681,Q15392,Q9H2C2,P04066,P51648,P17900,Q8NBX0,Q53GQ0,P23786,P38571,O14880,Q9Y5P4,Q9H6K4,Q14534,Q15067,Q06136,P07686,Q9BV10,O15118,P16435 70 +Activation of innate immune response 0.3252932512517958 0.1962963225531061 0.8443782395780133 1.0 1.0 18 Q7Z434,Q96PK6,Q9NUD5,O60828 4 +Positive regulation of cell death 0.3174092419281343 0.1947112473728862 0.8456190063093141 1.0 1.0 98 P11717,Q9NQX7,O95831,Q15375,O94813,Q9NS69,P30536,O00429,P05198,Q13501,Q07021,P53634,P30154,Q9Y3D6,O95140,O75569,Q99956,Q9NZJ7 18 +Positive regulation of proteolysis 0.2999041067359429 0.1944884803421562 0.8457934148726538 1.0 1.0 82 P04062,Q9Y3D6,O95831,P05067,P53990,Q99538,P53634,Q6P1A2,Q92542,P46379,O43847,Q9NZJ7,Q06787 13 +Protein ufmylation 0.4117424242424371 0.1942118325817505 0.8460100182065793 1.0 1.0 4 Q9Y3C8,O94874,Q96HY6 3 +Sertoli cell differentiation 0.459674365770525 0.1918646817698895 0.8478482032844061 1.0 1.0 3 P51659,Q14151 2 +Entrainment of circadian clock 0.3956043956044028 0.1897816623165223 0.8494802260941443 1.0 1.0 5 P62140,P04637,P62136,Q9BWF3 4 +Photoperiodism 0.3956043956044028 0.1897816623165223 0.8494802260941443 1.0 1.0 5 P62140,P04637,P62136,Q9BWF3 4 +Peptidyl tyrosine modification 0.3424601872171751 0.1866085978557679 0.8519675250549226 1.0 1.0 33 O14786,P14174,Q9H223,Q15375,Q99816,P61225,P05067,Q9H2J4 8 +I kappab phosphorylation 0.4083333333333455 0.1863137332600438 0.8521987384365537 1.0 1.0 4 O15111,Q96HY6,Q13162 3 +Histone h4 r3 methylation 0.5556396669189935 0.1851888542084004 0.8530809109444781 1.0 1.0 2 O14744 1 +Positive regulation of protein tyrosine kinase activity 0.407575757575762 0.1845823329630373 0.8535566440757483 1.0 1.0 4 P18031,Q8IZP0,Q15334 3 +Regulation of dna primase activity 0.4536160545247907 0.1805038664916079 0.8567570192300644 1.0 1.0 3 Q9BRX5,P49643 2 +Positive regulation of cytoplasmic translation 0.3553251042485786 0.1800041932010251 0.8571492762726061 1.0 1.0 10 O60506 1 +Regulation of osteoclast differentiation 0.4532374100719276 0.1798104606462062 0.8573013710629618 1.0 1.0 3 P42345,P35222 2 +Transmembrane receptor protein tyrosine kinase signaling pathway 0.3163012910616493 0.1785037366652847 0.8583273868900227 1.0 1.0 64 Q99523,O14786,P11717,P43490,Q15375,P46108,Q9UQB8,O14654,P04899,Q99538,O95470,Q7L576 12 +Positive regulation of dna binding transcription factor activity 0.3421664854913478 0.177820480298106 0.8588639627252173 1.0 1.0 35 P02786,O75955,P05067 3 +Cellular response to potassium ion 0.4521014767133552 0.1777420040599652 0.8589255959717998 1.0 1.0 3 P55011,Q15334 2 +Response to potassium ion 0.4521014767133552 0.1777420040599652 0.8589255959717998 1.0 1.0 3 P55011,Q15334 2 +Phosphatidylinositol dephosphorylation 0.3909866127650572 0.1771380445720208 0.859399959172398 1.0 1.0 5 Q10713 1 +Positive regulation of hormone secretion 0.340359838196303 0.1731530075735624 0.8625311601345658 1.0 1.0 12 O95563,P00367,P51809 3 +Fibroblast migration 0.3428837402050415 0.1723284827775067 0.8631792932841196 1.0 1.0 11 Q06481 1 +Positive regulation of protein binding 0.3278997420117785 0.170617911418159 0.86452421316524 1.0 1.0 22 O75955,Q9BUN8,P05067 3 +Glycolytic fermentation 0.4479363877319176 0.1703086465989571 0.864767411598693 1.0 1.0 3 O75746,Q9NQ88 2 +Fermentation 0.4479363877319176 0.1703086465989571 0.864767411598693 1.0 1.0 3 O75746,Q9NQ88 2 +Regulation of generation of precursor metabolites and energy 0.3385290560903033 0.1698193602662119 0.8651522007866923 1.0 1.0 31 P14406,P05067 2 +Negative regulation of smoothened signaling pathway 0.4007575757575881 0.169391280785006 0.8654888813305366 1.0 1.0 4 P55072,Q2M1P5,P06400 3 +Regulation of protein localization to chromatin 0.4460431654676177 0.1670082888609687 0.8673635269577731 1.0 1.0 3 P06400,Q7Z5K2 2 +Positive regulation of mitochondrial membrane potential 0.4460431654676149 0.1670082888609642 0.8673635269577766 1.0 1.0 3 Q9UJZ1,P31751 2 +Positive regulation of insulin secretion 0.3613839120582761 0.166780386761051 0.8675428516230916 1.0 1.0 9 O95563,P00367 2 +Paraxial mesoderm development 0.5446631339893975 0.1667514103217605 0.8675656522099808 1.0 1.0 2 Q9HCM4 1 +Activation of immune response 0.3413788003172562 0.1665611450804718 0.8677153682740189 1.0 1.0 42 Q06481,Q96PK6,Q07666,P04439,Q07021,Q9NUD5,P46379 7 +Extrinsic apoptotic signaling pathway via death domain receptors 0.3360369573824494 0.1658478202887106 0.8682767120486325 1.0 1.0 13 Q99523,Q9NR28,P26583,P09601 4 +Dendritic spine development 0.3246910152416135 0.161440668952284 0.8717463375575032 1.0 1.0 21 Q9UQB8,Q06787 2 +Oligodendrocyte differentiation 0.3187700226330291 0.1590105146323953 0.8736605897549161 1.0 1.0 18 Q92542 1 +Electron transport chain 0.3288531971353597 0.158476048660968 0.8740816925552326 1.0 1.0 56 O96000,Q9H3K2,P04062,P48163,O75208,O14949,O43819,Q9UDW1,O43674,O75306,O43676,P20674,P16435 13 +Cd40 signaling pathway 0.4403634986747424 0.1574011518221428 0.8749287057491497 1.0 1.0 3 P35232,P05556 2 +Regulation of morphogenesis of a branching structure 0.4403634986747381 0.1574011518221358 0.8749287057491553 1.0 1.0 3 Q9NQC3,P35222 2 +Regulation of electron transfer activity 0.4403634986747349 0.1574011518221304 0.8749287057491595 1.0 1.0 3 Q9BSH4,O00483 2 +Regulation of cell development 0.2885619179051867 0.1538220092997802 0.87775007945859 1.0 1.0 75 O14786,Q15375,O94813,P46108,Q06481,Q9UQB8,P30536,P53990,Q07021,Q9Y5A9,Q96G23,P07196,P55209 13 +Positive regulation of calcium ion import 0.5359576078728148 0.1532304268319419 0.8782165638582737 1.0 1.0 2 P17931 1 +Negative regulation of immune system process 0.339216632715814 0.1528033659651503 0.8785533432536563 1.0 1.0 37 P14174,P46108,O94813,P01889,P09601,P10644,P04439,Q9Y5A9,P28070,Q9HCL2 10 +Apoptotic mitochondrial changes 0.3349613613227582 0.1523670938292161 0.8788974093319686 1.0 1.0 30 P12235,Q9H3K2,Q9Y3D6,P45880,O00429,O14737,P48506,Q96A26,Q3ZCQ8 9 +Tricarboxylic acid cycle 0.3213336179384889 0.1521491863217328 0.8790692706859018 1.0 1.0 20 P11177,O75874,P48735 3 +Positive regulation of endothelial cell apoptotic process 0.5344436033308021 0.1509776155874637 0.8799933736464327 1.0 1.0 2 Q53EL6 1 +Endothelial cell apoptotic process 0.5344436033308021 0.1509776155874637 0.8799933736464327 1.0 1.0 2 Q53EL6 1 +Microtubule anchoring at microtubule organizing center 0.3912878787878914 0.1494741849150597 0.8811794779665405 1.0 1.0 4 P49841,Q8TD16,Q15154 3 +Cellular response to molecule of bacterial origin 0.3242939375489267 0.1494090637445774 0.8812308601734478 1.0 1.0 22 P30536,Q9NUQ9,Q8WTV0 3 +Regulation of small molecule metabolic process 0.3378684009952973 0.1473913777090592 0.8828231107884748 1.0 1.0 45 Q06481,O75477,P05067,Q9BYT8,Q9H2C2,O75844,Q6P1A2,P16435,Q9UBM7 9 +Telomerase holoenzyme complex assembly 0.3901515151515256 0.1471772697481511 0.8829921013201076 1.0 1.0 4 Q15185,Q96HR8,P07900 3 +Morphogenesis of an endothelium 0.5310370931112702 0.146014896463516 0.8839096287864363 1.0 1.0 2 P35222 1 +Establishment of pigment granule localization 0.5306585919757671 0.1454725224094608 0.8843378088947906 1.0 1.0 2 Q13561 1 +Sensory perception of mechanical stimulus 0.3289140224307326 0.1448561320358703 0.8848244625924753 1.0 1.0 14 Q14108 1 +Response to growth factor 0.300807229626674 0.1402292252793115 0.8884788816045479 1.0 1.0 87 Q99523,O14786,Q9H223,Q06481,O94813,Q9UQB8,P46108,P50402,O00560,Q92896,P05067,Q99538 12 +Negative regulation of innate immune response 0.3307597034674341 0.1401728937024097 0.8885233881258787 1.0 1.0 13 P04439,P46108,P01889 3 +Dna deamination 0.4282468761832575 0.1383734398712331 0.8899452869796505 1.0 1.0 3 Q5RKV6,Q9NQT5 2 +Folic acid containing compound catabolic process 0.5249810749432172 0.1375524514922937 0.8905941364099739 1.0 1.0 2 Q8IYS1 1 +Programmed necrotic cell death 0.3300796285736512 0.1369065167929141 0.8911046876877591 1.0 1.0 13 Q13510,O00429 2 +Alcohol catabolic process 0.3533224758231277 0.1358741140403349 0.8919207996700405 1.0 1.0 9 Q8WTV0 1 +Cardiac muscle cell action potential 0.3322387545199621 0.1347507526573163 0.8928089442747185 1.0 1.0 12 P05026,Q14126,P78310,P16615 4 +Negative regulation of axon extension 0.4254059503354099 0.1341992017899838 0.8932450570828414 1.0 1.0 3 O14786 1 +Endocytic recycling 0.3176480382684618 0.1311587655350826 0.8956497144406204 1.0 1.0 20 Q96L92,Q9H223,Q9H4M9,Q15904 4 +Body fluid secretion 0.3309483751558181 0.1287750571665813 0.8975356426691978 1.0 1.0 12 Q13505,P52789,Q99808,P35670 4 +Corticosteroid receptor signaling pathway 0.3717317165593113 0.1280273955945636 0.8981272928910153 1.0 1.0 5 Q15185,O14497,P35232,Q04917 4 +Lymphocyte chemotaxis 0.4207465708618394 0.127586795406416 0.8984759814609147 1.0 1.0 3 P55011 1 +T cell chemotaxis 0.4207465708618394 0.127586795406416 0.8984759814609147 1.0 1.0 3 P55011 1 +Positive regulation of vasculature development 0.3194278471440724 0.1268999203774059 0.89901960966202 1.0 1.0 16 O14786,Q07157,P09601,P52789,Q9H2J4,Q9NZ08 6 +Gamma aminobutyric acid metabolic process 0.5166540499621404 0.1266591201357438 0.8992102025808648 1.0 1.0 2 O43175 1 +Secretory granule organization 0.4195380537675081 0.1259188744605878 0.8997961419356084 1.0 1.0 3 Q9H267,P22059 2 +Establishment of planar polarity of embryonic epithelium 0.4195380537675079 0.1259188744605875 0.8997961419356086 1.0 1.0 3 Q13308,O95487 2 +Male gamete generation 0.3109794345746582 0.1257805957410795 0.89990560212583 1.0 1.0 64 P11717,A0AVF1,P41208,Q8N2A8,Q08J23,P54619,Q9H8Y8,Q15067,Q07666,Q9BTX1,Q9Y5A9,O75718,P46379,O95470,Q9H0H5 15 +Regulation of response to wounding 0.3191877800029543 0.125652557901551 0.9000069574252043 1.0 1.0 16 Q16625,Q96G23 2 +Telencephalon development 0.333709569865733 0.1246797485888341 0.9007770905658684 1.0 1.0 34 Q96N66,O94813,O14949,Q96P11,Q96QD8 5 +Limbic system development 0.31582981603609 0.1244235751369369 0.9009799081242882 1.0 1.0 17 O14786,O75569,P46108,O14949 4 +Hormone mediated signaling pathway 0.3345519580743223 0.1234660552205148 0.9017380526028292 1.0 1.0 36 P42785,Q06481 2 +Small nucleolar ribonucleoprotein complex assembly 0.3776515151515186 0.1232376419069729 0.9019189188102636 1.0 1.0 4 Q9Y265,Q9NWS0,Q96HR8 3 +Regulation of receptor clustering 0.5136260408781135 0.1229077726184345 0.9021801306378 1.0 1.0 2 P46109 1 +Negative regulation of phosphoprotein phosphatase activity 0.3595381459679587 0.1219202694145648 0.9029621627096158 1.0 1.0 8 P62942,P17931,P04899 3 +Cellular response to retinoic acid 0.3682214637846118 0.1216266962284873 0.9031946699155364 1.0 1.0 7 Q13308,Q13573,P49841,Q99623,O95747,Q6IBS0 6 +Positive regulation of synaptic vesicle recycling 0.5109765329295892 0.1197158534508537 0.9047082414440863 1.0 1.0 2 Q9Y263 1 +Thioester biosynthetic process 0.3170209499716241 0.1173780269273468 0.9065604956665292 1.0 1.0 21 Q53GQ0,P50897,P11177,Q9UMR5 4 +Myoblast fusion 0.3668788721342422 0.1165990032887377 0.9071778275983732 1.0 1.0 5 O75955 1 +Sensory organ morphogenesis 0.314841095024004 0.1153790274470148 0.9081447016070074 1.0 1.0 20 Q13308,Q15555,P54802,O95140,O75569 5 +Heparan sulfate proteoglycan metabolic process 0.5056775170325414 0.1135822839969766 0.9095689317771284 1.0 1.0 2 P35222 1 +Heparan sulfate proteoglycan biosynthetic process 0.5056775170325414 0.1135822839969766 0.9095689317771284 1.0 1.0 2 P35222 1 +Epithelial tube morphogenesis 0.3253974403740094 0.1132054563712627 0.9098676699199872 1.0 1.0 27 P11233,Q15375,O94813,O00592 4 +Positive regulation of neuroblast proliferation 0.5037850113550242 0.1114716225082067 0.9112423672899732 1.0 1.0 2 P35222 1 +Lysine metabolic process 0.5034065102195212 0.1110544872539509 0.9115731393264136 1.0 1.0 2 Q9NRN7 1 +Positive regulation of metallopeptidase activity 0.5030280090840201 0.1106390117546059 0.9119026104737736 1.0 1.0 2 Q96HY6 1 +Negative regulation of glycolytic process 0.5030280090840177 0.1106390117546034 0.9119026104737756 1.0 1.0 2 Q9NQ88 1 +T helper 17 type immune response 0.5030280090840175 0.1106390117546031 0.9119026104737756 1.0 1.0 2 P35232 1 +Cellular response to growth hormone stimulus 0.5030280090840173 0.1106390117546028 0.911902610473776 1.0 1.0 2 P18031 1 +Growth hormone receptor signaling pathway via jak stat 0.5030280090840173 0.1106390117546028 0.911902610473776 1.0 1.0 2 P18031 1 +Lamellipodium organization 0.3202965162492875 0.1077099985616497 0.914225737954601 1.0 1.0 24 Q16625 1 +Regulation of cellular response to transforming growth factor beta stimulus 0.3237123123900379 0.1068149745948339 0.914935767434622 1.0 1.0 13 Q92896 1 +Positive regulation of blood circulation 0.4042372512096418 0.1064526829668446 0.9152231955354576 1.0 1.0 3 P16615 1 +Regulation of transporter activity 0.3329556674446635 0.105451355229087 0.9160176676020992 1.0 1.0 40 Q06787,Q96GC9,P27105,P05067 4 +Maintenance of protein location in cell 0.3122250537630454 0.1053057503425604 0.9161332002346884 1.0 1.0 17 P24390 1 +Histone h2a monoubiquitination 0.3670454545454624 0.1048354629365798 0.9165063697316784 1.0 1.0 4 Q13620,P63208,Q99496 3 +Negative regulation of protein import into nucleus 0.4958364875094577 0.1030568260571783 0.91791787032538 1.0 1.0 2 Q9UHD1 1 +Regulation of golgi organization 0.3608461502542379 0.1029393322397833 0.9180111208849184 1.0 1.0 5 Q9P2W9 1 +Positive regulation of golgi to plasma membrane protein transport 0.4006058311245725 0.1022731369905861 0.918539877057341 1.0 1.0 3 P98194,O95573 2 +Actin filament based movement 0.3176241362717562 0.1014187893974431 0.9192180215938142 1.0 1.0 23 Q9UM22 1 +Mitochondrial transcription 0.3990912533131344 0.1005787201269911 0.919884889908575 1.0 1.0 3 O00411,Q00059 2 +Tissue migration 0.3318474926818986 0.0999242237836157 0.9204044847980803 1.0 1.0 44 O94813,Q8WTV0,P42785,Q99538,Q9NQW6 5 +Endoplasmic reticulum unfolded protein response 0.3099822113169386 0.099206317889094 0.9209744586573508 1.0 1.0 19 P18031,O76024,P57088,P05198,Q9Y4P3,Q9BUN8 6 +Negative regulation of phosphatase activity 0.3432411104059845 0.0989486019096294 0.921179079475092 1.0 1.0 9 P62942,P17931,P04899 3 +I kappab kinase nf kappab signaling 0.3313207557391326 0.0982890837562469 0.9217027461100749 1.0 1.0 45 P62942,Q8TB61,P02786,O43657,Q9Y3E0,Q13501,Q7Z434,Q5T9L3 8 +Ether biosynthetic process 0.3629838496468521 0.0982510048807848 0.9217329823083515 1.0 1.0 4 O15228 1 +Response to peptide 0.2949371984712247 0.0976078949427966 0.9222436551880062 1.0 1.0 85 Q99523,P07196,P43490,Q06481,Q16836,Q9UQB8,P46108,P35613,P05067,O14654,Q99538,P09960,P16435,P04899,Q7L576 15 +Positive regulation of cell population proliferation 0.310032834267948 0.097343476310745 0.9224536308155152 1.0 1.0 99 O14786,P43490,P02786,P30536,O00560,O95630,P04899,P04439,Q99538,Q9H2J4,P43307,Q9HCL2,P55209 13 +Rrna pseudouridine synthesis 0.3621212121212167 0.096885358602232 0.922817436244962 1.0 1.0 4 O60832,Q9NY12,Q96HR8 3 +Regulation of lipid storage 0.366442818503391 0.0966960841183133 0.9229677496800694 1.0 1.0 6 Q8WTV0 1 +Leukocyte tethering or rolling 0.4890234670703961 0.0964085634071341 0.9231960911913676 1.0 1.0 2 P05556 1 +Regulation of vesicle mediated transport 0.3099456754188306 0.0963450654255088 0.9232465204997696 1.0 1.0 99 O14786,O75955,Q9H223,P11279,Q06481,Q8WTV0,P11233,P50897,O00560,P05067,P51809,P04899,Q9P2W9,Q06787 14 +Acetyl coa biosynthetic process from pyruvate 0.3597024079201941 0.0962080269502961 0.9233553558059676 1.0 1.0 7 P11177 1 +Negative regulation of leukocyte cell cell adhesion 0.3512898330804256 0.0948071414185631 0.9244680143944484 1.0 1.0 8 P04083,Q92990,P32119,P10644,P17931,Q14160,P09429 7 +Cytosolic transport 0.3261726444708165 0.0944785078895248 0.9247290542887026 1.0 1.0 52 Q99523,Q8N2H4,P11279,O75503 4 +Protein targeting to peroxisome 0.3934115865202585 0.0944766626118465 0.9247305200509456 1.0 1.0 3 O75381,P40855 2 +Cd4 positive alpha beta t cell activation 0.3569533914361519 0.0944503017008237 0.924751459381651 1.0 1.0 5 Q9UJZ1,P40763,P42345,P09429 4 +Microtubule anchoring at centrosome 0.3911397198031021 0.0921457455419471 0.9265822433433512 1.0 1.0 3 P49841,Q15154 2 +Regulation of clathrin dependent endocytosis 0.4841029523088473 0.0919207999554192 0.9267609654493288 1.0 1.0 2 P50570 1 +Membrane docking 0.317317063955908 0.0905136971341968 0.9278790098922728 1.0 1.0 24 O15400,O00186,P16615,Q96GC9,P51149,Q13190,Q9UNK0 7 +Vascular associated smooth muscle cell proliferation 0.3334986730596879 0.0903586694570107 0.9280021992860852 1.0 1.0 10 O95140,P04899 2 +Positive regulation of muscle cell differentiation 0.3576561295027591 0.0902935942165883 0.928053910434119 1.0 1.0 7 Q14012 1 +Skeletal muscle tissue regeneration 0.3568181818181942 0.0887414023386904 0.9292874280070816 1.0 1.0 4 Q7Z4V5,P58546,P52294 3 +Cellular lipid metabolic process 0.372398906998367 0.0886272388736939 0.9293781597721682 1.0 1.0 165 Q8NHP8,Q13510,Q16836,Q9HB40,Q9H7Z7,P50897,P06280,P07602,O75874,Q96G23,Q9HCL2,P06865,P35790,Q10713,P16278,O14975,P61916,O15269,O75477,Q99735,Q16739,O75844,Q6P1A2,Q8N4Q0,Q9BWD1,P48449,O95470,P04062,Q06481,Q96N66,Q8WTV0,Q8NCC3,Q9H2C2,P04066,P51648,P17900,Q8NBX0,Q53GQ0,P23786,Q9Y5P4,Q15067,Q06136,P07686,Q9BV10,P16435,Q9NZJ7 46 +Mrna 3 end processing 0.3263594723901464 0.0867799727028582 0.9308464070269318 1.0 1.0 32 P05067 1 +Rab protein signal transduction 0.3850814085573645 0.0862303781948592 0.9312832823315738 1.0 1.0 3 Q15286,Q9UL25 2 +Negative regulation of calcium ion transport into cytosol 0.3545454545454632 0.0853827992652141 0.9319570674195868 1.0 1.0 4 P62942,P30626,P78417 3 +Positive regulation of sequestering of calcium ion 0.3545454545454632 0.0853827992652141 0.9319570674195868 1.0 1.0 4 P30626,P78417,P62942 3 +Regulation of ryanodine sensitive calcium release channel activity 0.3545454545454632 0.0853827992652141 0.9319570674195868 1.0 1.0 4 P62942,P30626,P78417 3 +Negative regulation of ryanodine sensitive calcium release channel activity 0.3545454545454632 0.0853827992652141 0.9319570674195868 1.0 1.0 4 P30626,P78417,P62942 3 +Positive regulation of epithelial cell migration 0.3191285401279023 0.0838590409357094 0.9331685054023332 1.0 1.0 26 Q99538 1 +Regulation of actin nucleation 0.3609515251650599 0.082570480316369 0.9341930743926492 1.0 1.0 6 Q7L576 1 +Regulation of establishment or maintenance of cell polarity 0.3548499967044428 0.0823057865969744 0.9344035529964332 1.0 1.0 7 Q14254 1 +Multi organism reproductive process 0.3427989948073737 0.081028681160126 0.9354191432265616 1.0 1.0 133 O60879,P07858,Q9BQE5,P05067,Q07666,P11717,Q8N2A8,P45880,P46379,O95470,Q96GC9,Q01085,Q9UIQ6,P35613,Q9BTX1,O75718,A0AVF1,Q15067,Q07021,P78310,P07686,Q9Y5A9,Q96QD8,Q8NB78,Q9H0H5 25 +Regulation of anatomical structure size 0.2912524635692416 0.0804980119404225 0.9358411773471952 1.0 1.0 83 Q15375,Q9UQB8,Q9HB40,P51790,P42892 5 +Regulation of reactive oxygen species metabolic process 0.3154577695383351 0.0798926514241178 0.9363226344621932 1.0 1.0 24 P42785,P30536,P51790 3 +Regulation of epithelial cell apoptotic process 0.3463074557149608 0.079053902876865 0.9369897488809602 1.0 1.0 8 P09601,P05198 2 +Phospholipid biosynthetic process 0.3292306050701247 0.0789046194487018 0.9371084889115038 1.0 1.0 41 P35790,Q92604,Q10713,O15270,Q96N66,P22059,O15228,O15269,P07686,O75874,Q6P1A2,Q9NPH0,Q9HCL2 13 +Monovalent inorganic anion homeostasis 0.3752294819246874 0.0775149376693224 0.9382139084855106 1.0 1.0 3 P55011 1 +Negative regulation of peptide secretion 0.3489566655476086 0.0774566208980989 0.938260299062073 1.0 1.0 4 Q16836 1 +Negative regulation of hormone secretion 0.3489566655476086 0.0774566208980989 0.938260299062073 1.0 1.0 4 Q16836 1 +Calcineurin mediated signaling 0.3486169003410423 0.077136618311682 0.938514862568187 1.0 1.0 5 P42345,P49841,P26599,Q9UHD1 4 +Inositol phosphate mediated signaling 0.3486169003410423 0.077136618311682 0.938514862568187 1.0 1.0 5 P42345,P49841,P26599,Q9UHD1 4 +Regulation of calcineurin mediated signaling 0.3486169003410423 0.077136618311682 0.938514862568187 1.0 1.0 5 P42345,P49841,P26599,Q9UHD1 4 +Medium chain fatty acyl coa metabolic process 0.4636638909916619 0.0759293721062174 0.9394752887438468 1.0 1.0 2 P51659 1 +Exploration behavior 0.3710715638015887 0.0741599041210429 0.940883149836148 1.0 1.0 3 Q9HB07,Q15334 2 +Sertoli cell development 0.4595003785011243 0.0731630776777503 0.941676347359603 1.0 1.0 2 P51659 1 +Retrograde transport endosome to golgi 0.3171996839044224 0.0726386605578059 0.9420936612885108 1.0 1.0 26 O75503 1 +Negative regulation of cyclin dependent protein serine threonine kinase activity 0.3446543696656791 0.0716740390483073 0.9428613168505684 1.0 1.0 4 O95373 1 +Regulation of collagen metabolic process 0.3676637637258615 0.0715480177717325 0.9429616097933512 1.0 1.0 3 P08670,P05556 2 +Rhythmic process 0.3249641986657246 0.0708699015686131 0.9435012981926164 1.0 1.0 50 P43490,Q14103,O94813,O00429,P54802,Q03164,O95470 7 +Positive regulation of epithelial cell proliferation 0.3054541315407539 0.0702572417607807 0.943988914500426 1.0 1.0 17 O14786,Q9NQC3,P09601,O95747,O75340,Q9H2J4 6 +Negative regulation of mitophagy 0.4477668433005184 0.0661843711652473 0.9472310394940424 1.0 1.0 2 Q9NQ88 1 +Dna damage response signal transduction by p53 class mediator resulting in cell cycle arrest 0.4477668433005184 0.066184371165247 0.9472310394940426 1.0 1.0 2 P61254 1 +Protein dna covalent cross linking repair 0.445874337623008 0.0651663158546767 0.9480415801546273 1.0 1.0 2 Q9Y6I9 1 +Response to muramyl dipeptide 0.3581976524043923 0.0649190675688278 0.9482384388928292 1.0 1.0 3 Q92974,P08670 2 +Leukocyte adhesion to vascular endothelial cell 0.3581976524043851 0.0649190675688234 0.9482384388928328 1.0 1.0 3 P05556,Q13464 2 +Oxidative demethylation 0.4436033308099807 0.0639822774599529 0.9489843384282808 1.0 1.0 2 Q9C0B1 1 +Oxidative rna demethylation 0.4436033308099807 0.0639822774599529 0.9489843384282808 1.0 1.0 2 Q9C0B1 1 +Positive regulation of fatty acid metabolic process 0.3566830745929544 0.0639408796340329 0.9490173016178398 1.0 1.0 3 Q92604,P31751 2 +Artery development 0.3415339970797876 0.063359565779629 0.94948018436022 1.0 1.0 5 O14786 1 +Single fertilization 0.3072064520501637 0.0630254262416138 0.9497462573532875 1.0 1.0 21 P45880 1 +Regulation of cyclic nucleotide phosphodiesterase activity 0.3544112078758078 0.0625147629374774 0.9501529058106856 1.0 1.0 3 P63244,O00170 2 +Calcium ion export 0.3544112078758072 0.0625147629374772 0.9501529058106856 1.0 1.0 3 P62258,O95202 2 +Regulation of mammary gland epithelial cell proliferation 0.4401968205904526 0.0622814139820736 0.9503387292329686 1.0 1.0 2 Q9NQC3 1 +Immune response 0.3895548732905972 0.0616104216547348 0.9508730774309132 1.0 1.0 189 O15400,O00584,O43657,Q96PK6,P05067,Q07666,Q8TCT8,O00115,Q9UQ84,Q9NZ08,P01889,P46108,Q96FW1,P04439,P46379,Q9NPR9,Q9UNK0,Q06481,Q9NUQ9,P53634,P10321,P28070,P55899,Q5KU26,O75955,P11279,Q9Y487,Q9Y5P4,P02786,O95373,P51809,Q07021,Q9Y5A9,Q9NUD5,O60506,O75569,Q14254 37 +Positive regulation of fibroblast proliferation 0.3521607278241042 0.0610331402476011 0.951332816141699 1.0 1.0 6 P14174,Q08211,P11802,Q7Z5K2,P14635 5 +Monocarboxylic acid transport 0.3470738810440996 0.0609261373143219 0.9514180335415524 1.0 1.0 7 O95563,P53985 2 +Insulin secretion 0.3068057946059138 0.0608589641397621 0.951471530707285 1.0 1.0 21 Q16836,P22059,P00367,P53985,O95563,Q9BRT2,O00186 7 +Negative regulation of antigen receptor mediated signaling pathway 0.3506247633472142 0.0602453735309575 0.9519602084669234 1.0 1.0 3 P17931,P15311 2 +Negative regulation of t cell receptor signaling pathway 0.3506247633472142 0.0602453735309575 0.9519602084669234 1.0 1.0 3 P17931,P15311 2 +Positive regulation of intrinsic apoptotic signaling pathway in response to dna damage 0.4341408024223954 0.0594722906244264 0.9525759352791016 1.0 1.0 2 P61254 1 +Positive regulation of protein acetylation 0.3464984938621421 0.0593889154627035 0.9526423416562138 1.0 1.0 7 Q14012 1 +Microvillus assembly 0.3514063992715803 0.0592476311024986 0.9527548721134832 1.0 1.0 6 O00592 1 +Response to growth hormone 0.3472169632714904 0.0583146721492357 0.953497980718391 1.0 1.0 3 P18031,P40763 2 +Coronary vasculature development 0.3385102450644194 0.0577397676619668 0.953955916505931 1.0 1.0 5 O14786 1 +Polysaccharide biosynthetic process 0.3148479407987004 0.0573858852272937 0.9542378064301796 1.0 1.0 12 Q8N6G5,O43505 2 +Biological adhesion 0.3406026176199962 0.0564310872841907 0.9549983923335684 1.0 1.0 133 Q9UM22,Q15375,P05067,Q9HCL2,Q08380,Q92544,Q14126,O14786,P46108,P10644,P04439,O00592,Q96GC9,P05026,Q8WTV0,P35613,Q9NUQ9,Q14574,Q53GQ0,O75955,P61225,Q9UQB8,P02786,Q07021,P78310,Q14254 26 +Positive regulation of myeloid leukocyte differentiation 0.4261922785768235 0.0561786924640435 0.9551994553015336 1.0 1.0 2 P06400 1 +Insulin receptor signaling pathway 0.3090883563560206 0.0535332484051489 0.9573070402236364 1.0 1.0 23 P43490,P04899,Q9UQB8,O14654 4 +Enzyme linked receptor protein signaling pathway 0.3040647701376645 0.0533947612040956 0.9574173792139196 1.0 1.0 97 Q15375,Q96PK6,O14654,Q99538,Q7L576,P11717,O14786,P43490,P62993,P46108,O95470,P62942,Q06481,O00560,Q92896,Q9UIQ6,Q99523,Q9UQB8,P04899 19 +Regulation of calcium mediated signaling 0.3487490523123461 0.0530372448048332 0.9577022323979264 1.0 1.0 6 P42345,P49841,Q9UHD1,P0DP25,P26599 5 +Amyloid beta formation 0.3233692740705522 0.0521651500901685 0.9583971013075396 1.0 1.0 10 Q92542 1 +Response to transforming growth factor beta 0.3148355936358828 0.0508969343819918 0.959407648354387 1.0 1.0 27 Q06481,P46108,O00560,Q92896,O14737 5 +Activation induced cell death of t cells 0.3269121363180211 0.0506719215340016 0.9595869512659434 1.0 1.0 4 Q9HCL2 1 +Dna methylation or demethylation 0.3005212892103237 0.048726673552767 0.9611371186978968 1.0 1.0 19 O75844,Q8N2A8 2 +Positive regulation of gastrulation 0.400454201362599 0.0481646515776344 0.961585021430404 1.0 1.0 2 O95747 1 +Female meiosis i 0.3237410071942436 0.0476254404160379 0.9620147565110168 1.0 1.0 3 O14965,O95067 2 +Activation of phospholipase d activity 0.322983718288526 0.0473495134530215 0.9622346662792668 1.0 1.0 3 P18085,P40616 2 +Deoxyribonucleoside triphosphate biosynthetic process 0.3226050738356671 0.0472130173619349 0.9623434527378408 1.0 1.0 3 P04818,P55263 2 +Nucleolar chromatin organization 0.3222264293828129 0.0470774935255106 0.9624514650096416 1.0 1.0 3 O43159,Q9UPP1 2 +Gpi anchor metabolic process 0.3887206661619938 0.0456249902207335 0.9636091505935548 1.0 1.0 2 Q969N2 1 +Phagolysosome assembly 0.3173040514956473 0.0454021157591566 0.9637867945964482 1.0 1.0 3 P51149,P61106 2 +Phagosome maturation 0.3173040514956473 0.0454021157591566 0.9637867945964482 1.0 1.0 3 P51149,P61106 2 +Negative regulation of tyrosine phosphorylation of stat protein 0.3822861468584321 0.0444726590355057 0.9645276453363518 1.0 1.0 2 P30153 1 +Negative regulation of receptor signaling pathway via stat 0.3822861468584321 0.0444726590355057 0.9645276453363518 1.0 1.0 2 P30153 1 +Negative regulation of receptor signaling pathway via jak stat 0.3822861468584321 0.0444726590355057 0.9645276453363518 1.0 1.0 2 P30153 1 +Histone h3 k36 demethylation 0.3777441332323932 0.0437503882815597 0.9651033736009108 1.0 1.0 2 Q9H6W3 1 +Negative regulation of histone h3 k9 methylation 0.319696969696975 0.0433879888631984 0.965392252184545 1.0 1.0 4 O60341,Q9NWS0,Q12824 3 +Vascular associated smooth muscle cell apoptotic process 0.3196969696969745 0.0433879888631978 0.9653922521845456 1.0 1.0 4 O95140,Q53EL6,P04179 3 +Negative regulation of response to endoplasmic reticulum stress 0.3115131980654964 0.0433823570446515 0.9653967414985662 1.0 1.0 12 O76024,O95881,Q6P1A2 3 +Positive regulation of collagen metabolic process 0.3675246025737986 0.0423709994738929 0.9662029466470796 1.0 1.0 2 P08670 1 +Cilium or flagellum dependent cell motility 0.3603330809992347 0.0415800809182348 0.9668334526315876 1.0 1.0 2 Q9GZT3 1 +Regulation of er associated ubiquitin dependent protein catabolic process 0.3021582733812993 0.0411694193977168 0.9671608327801492 1.0 1.0 3 O43765,P51572 2 +Negative regulation of osteoblast differentiation 0.3516275548826588 0.0407919708702518 0.96746174035011 1.0 1.0 2 Q9H6W3 1 +Peptidyl tyrosine dephosphorylation involved in inactivation of protein kinase activity 0.3504920514761488 0.0407014154543523 0.9675339331628352 1.0 1.0 2 P18031 1 +T cell homeostasis 0.3432293174083516 0.0405360356772127 0.9676657783242548 1.0 1.0 6 O95067,Q9HCL2 2 +Spindle elongation 0.3283087854408334 0.0399331113351651 0.9681464531201296 1.0 1.0 5 Q02241 1 +Regulation of hydrogen peroxide biosynthetic process 0.338001514004536 0.0398657339806988 0.9682001696965484 1.0 1.0 2 P00403 1 +Positive regulation of hydrogen peroxide metabolic process 0.338001514004536 0.0398657339806988 0.9682001696965484 1.0 1.0 2 P00403 1 +Endomembrane system organization 0.3390715606100667 0.0393446076735411 0.9686156423498696 1.0 1.0 133 Q96CP7,Q9UL15,Q13501,O15260,Q14108,Q9H6H4,Q9H8Y8,O00429,P51790,Q15041,Q9NPA0,Q16739,O75844,Q8NFQ8,Q6P1A2,P16615,P46379,Q96GC9,Q99816,Q7L5D6,P50402,O43681,O43760,Q9H2C2,Q15629,Q96A33,O95197,Q00765,O75955,Q9UQB8,Q9Y5P4,P53990,Q86XL3,Q9P2W9 34 +Spermatid nucleus differentiation 0.2934494509655465 0.0392869350956281 0.9686616228589024 1.0 1.0 3 P26583,Q96SB4 2 +Epigenetic maintenance of chromatin in transcription competent conformation 0.3221044663133922 0.0391476568640557 0.9687726653851014 1.0 1.0 2 O14497 1 +Kinetochore assembly 0.2870124952669469 0.0381168889875757 0.9695944856304431 1.0 1.0 3 P50748,Q7Z3K3 2 +Hippocampus development 0.3059776180253749 0.036843882447346 0.9706094846509584 1.0 1.0 14 P46108,O14949 2 +Pyrimidine deoxyribonucleoside monophosphate biosynthetic process 0.2756531616811846 0.0364478569541291 0.970925255177178 1.0 1.0 3 P04818,P34896 2 +Dtmp metabolic process 0.2756531616811846 0.0364478569541291 0.970925255177178 1.0 1.0 3 P04818,P34896 2 +Pyrimidine deoxyribonucleoside monophosphate metabolic process 0.2756531616811846 0.0364478569541291 0.970925255177178 1.0 1.0 3 P04818,P34896 2 +Type b pancreatic cell apoptotic process 0.3113266908247963 0.0357967302421276 0.9714444402865464 1.0 1.0 4 P05198 1 +Regulation of mitochondrial dna replication 0.262021961378269 0.0349960766795407 0.9720828693147632 1.0 1.0 3 Q9UJZ1,Q04837 2 +5s class rrna transcription by rna polymerase iii 0.3098484848484883 0.0345485821020661 0.9724397025347952 1.0 1.0 4 Q8WUA4,Q12789,Q9UKN8 3 +Trna transcription 0.3098484848484883 0.0345485821020661 0.9724397025347952 1.0 1.0 4 Q8WUA4,Q12789,Q9UKN8 3 +Peptidyl lysine hydroxylation 0.3235143457117874 0.032175618460057 0.9743319997597466 1.0 1.0 5 Q92791 1 +Smooth muscle cell apoptotic process 0.3198181129215635 0.0264593940746887 0.9788909210843966 1.0 1.0 5 O95140,Q53EL6,P98175,P04179 4 +Body morphogenesis 0.3304402846871005 0.0190398671560291 0.9848093017752416 1.0 1.0 7 O75787 1 +Positive regulation of cell substrate adhesion 0.300730164180397 0.0183864934064935 0.9853305273229772 1.0 1.0 22 Q07021,O14786,P46108 3 +Regulation of protein localization to membrane 0.3190120530426199 0.0182340117882499 0.9854521696589228 1.0 1.0 37 O15400,P27105,O00264,Q13501,Q9Y3D6,Q9UNK0 6 +Negative regulation of response to cytokine stimulus 0.329180459361895 0.0160860339014114 0.9871657554071288 1.0 1.0 7 O94813 1 +Positive regulation of dendritic cell cytokine production 0.312497004330285 0.0158089856338003 0.9873867798341538 1.0 1.0 5 Q7Z434 1 +Dendritic cell cytokine production 0.312497004330285 0.0158089856338003 0.9873867798341538 1.0 1.0 5 Q7Z434 1 +Myeloid dendritic cell cytokine production 0.312497004330285 0.0158089856338003 0.9873867798341538 1.0 1.0 5 Q7Z434 1 +Positive regulation of peptidyl lysine acetylation 0.2803030303030333 0.0148752500690148 0.9881317053224544 1.0 1.0 4 Q9Y230,Q9NWS0,Q12824 3 +Positive regulation of histone acetylation 0.2803030303030333 0.0148752500690148 0.9881317053224544 1.0 1.0 4 Q9Y230,Q9NWS0,Q12824 3 +Organelle membrane fusion 0.2915899537231176 0.0144897975664694 0.9884392187731308 1.0 1.0 18 Q9UNK0,O15400,Q13190,P51809 4 +Regulation of cardiac muscle contraction 0.3167020042232786 0.0118723591486826 0.9905274504660552 1.0 1.0 9 Q14126 1 +Immunoglobulin production 0.2994716730058013 0.0118074652269807 0.990579224695188 1.0 1.0 22 P02786 1 +Regulation of anoikis 0.2715909090909165 0.0107735806770997 0.9914040926013864 1.0 1.0 4 Q07820,P05556,Q9Y3E5 3 +Nuclear membrane organization 0.2908307978445923 0.0107424288675278 0.9914289467110012 1.0 1.0 18 P50402,Q86XL3 2 +Response to virus 0.2750314632429514 0.009232233944362 0.9926338477155024 1.0 1.0 74 O43657,P61916,Q9HCE1,Q07021,O75844,Q9NUD5,O75569,Q9HCL2,Q06787 9 +Leukocyte cell cell adhesion 0.3101999868773907 0.0090152401246724 0.9928069765276883 1.0 1.0 29 P02786,P10644,P04439,Q9HCL2,Q14254 5 +Regulation of stem cell proliferation 0.2632575757575837 0.0074604101296818 0.9940475091573316 1.0 1.0 4 O60341,Q00839,P26583 3 +Carbohydrate homeostasis 0.3159247216170509 0.00683457244706 0.99454684261892 1.0 1.0 35 O76024,Q06481,P22059,P52789,P53985,P42785,Q99808,P48506,O95563,Q12824,O00186 11 +Lipid modification 0.3187289840026011 0.0066983639332544 0.9946555188011486 1.0 1.0 45 P23786,P04062,Q10713,Q16836,Q06481,O14975,Q96N66,Q15067,Q9BWD1 9 +Positive regulation of type i interferon production 0.2897972911349576 0.0056688682915159 0.9954769217386455 1.0 1.0 18 O75955,Q9NUD5 2 +Positive regulation of cell development 0.3148314870364543 0.0035648540778711 0.997155663994144 1.0 1.0 52 O14786,P46108,O94813,Q9UQB8,P30536,P53990,Q07021,P07196,P55209 9 +Reactive oxygen species metabolic process 0.3143495824611142 0.0020438582295295 0.9983692382095676 1.0 1.0 34 P42785,Q15067,P51790 3 +Regulation of rho protein signal transduction 0.3087022030733509 0.0011427156856524 0.9990882449954588 1.0 1.0 10 O75955 1 diff --git a/msigdb_gobp/selections.json b/msigdb_gobp/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..d10290ec5e448c4d8a82fa27e1e89262eb0fe76a --- /dev/null +++ b/msigdb_gobp/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["10 formyltetrahydrofolate metabolic process", "2 oxoglutarate metabolic process", "2fe 2s cluster assembly", "3 phosphoadenosine 5 phosphosulfate biosynthetic process", "3 phosphoadenosine 5 phosphosulfate metabolic process", "3 utr mediated mrna destabilization", "3 utr mediated mrna stabilization", "5 phosphoribose 1 diphosphate metabolic process", "5s class rrna transcription by rna polymerase iii", "Abscission", "Acetyl coa biosynthetic process", "Acetyl coa biosynthetic process from pyruvate", "Acetyl coa metabolic process", "Acid secretion", "Acidic amino acid transport", "Acrosome assembly", "Actin crosslink formation", "Actin cytoskeleton reorganization", "Actin filament based movement", "Actin filament based process", "Actin filament based transport", "Actin filament bundle organization", "Actin filament depolymerization", "Actin filament network formation", "Actin filament organization", "Actin filament polymerization", "Actin filament reorganization", "Actin filament severing", "Actin mediated cell contraction", "Actin modification", "Actin myosin filament sliding", "Actin nucleation", "Actin polymerization dependent cell motility", "Actin polymerization or depolymerization", "Action potential", "Activated t cell proliferation", "Activation induced cell death of t cells", "Activation of adenylate cyclase activity", "Activation of cysteine type endopeptidase activity", "Activation of cysteine type endopeptidase activity involved in apoptotic process", "Activation of cysteine type endopeptidase activity involved in apoptotic process by cytochrome c", "Activation of gtpase activity", "Activation of immune response", "Activation of innate immune response", "Activation of nf kappab inducing kinase activity", "Activation of phospholipase c activity", "Activation of phospholipase d activity", "Activation of protein kinase activity", "Activation of protein kinase b activity", "Activation of protein kinase c activity", "Activin receptor signaling pathway", "Actomyosin contractile ring organization", "Actomyosin structure organization", "Acute inflammatory response", "Acute inflammatory response to antigenic stimulus", "Acute phase response", "Acyl carnitine transmembrane transport", "Acylglycerol homeostasis", "Acylglycerol transport", "Adaptation of signaling pathway", "Adaptive immune response", "Adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains", "Adaptive thermogenesis", "Adenosine metabolic process", "Adenosine to inosine editing", "Adenylate cyclase activating adrenergic receptor signaling pathway", "Adenylate cyclase activating adrenergic receptor signaling pathway involved in heart process", "Adenylate cyclase activating dopamine receptor signaling pathway", "Adenylate cyclase activating g protein coupled receptor signaling pathway", "Adenylate cyclase inhibiting dopamine receptor signaling pathway", "Adenylate cyclase inhibiting g protein coupled receptor signaling pathway", "Adenylate cyclase modulating g protein coupled receptor signaling pathway", "Adherens junction assembly", "Adherens junction maintenance", "Adherens junction organization", "Adhesion of symbiont to host", "Adhesion of symbiont to host cell", "Adiponectin activated signaling pathway", "Adipose tissue development", "Adp biosynthetic process", "Adp metabolic process", "Adp transport", "Adrenal gland development", "Adrenergic receptor signaling pathway", "Adult behavior", "Adult locomotory behavior", "Aerobic respiration", "Aggrephagy", "Aggresome assembly", "Aging", "Alanine transport", "Alcohol biosynthetic process", "Alcohol catabolic process", "Alcohol metabolic process", "Aldehyde biosynthetic process", "Aldehyde catabolic process", "Alditol biosynthetic process", "Alditol catabolic process", "Alditol metabolic process", "Alditol phosphate metabolic process", "Alkanesulfonate metabolic process", "Allantoin metabolic process", "Alpha amino acid catabolic process", "Alpha amino acid metabolic process", "Alpha beta t cell activation", "Alpha beta t cell differentiation", "Alpha beta t cell proliferation", "Alpha ketoglutarate transport", "Alpha linolenic acid metabolic process", "Alternative mrna splicing via spliceosome", "Ameboidal type cell migration", "Amelogenesis", "Amide biosynthetic process", "Amide transport", "Amine biosynthetic process", "Amine catabolic process", "Amine metabolic process", "Amine transport", "Amino acid activation", "Amino acid betaine biosynthetic process", "Amino acid betaine metabolic process", "Amino acid betaine transport", "Amino acid homeostasis", "Amino acid import", "Amino acid import across plasma membrane", "Amino acid neurotransmitter reuptake", "Amino acid salvage", "Amino acid transmembrane transport", "Amino acid transport", "Amino sugar biosynthetic process", "Amino sugar catabolic process", "Amino sugar metabolic process", "Aminoacyl trna metabolism involved in translational fidelity", "Aminoglycan biosynthetic process", "Aminoglycan catabolic process", "Aminoglycan metabolic process", "Aminoglycoside antibiotic metabolic process", "Aminophospholipid transport", "Ammonium ion metabolic process", "Ammonium transmembrane transport", "Amp biosynthetic process", "Amp metabolic process", "Amp salvage", "Ampa glutamate receptor clustering", "Amygdala development", "Amyloid beta clearance", "Amyloid beta clearance by cellular catabolic process", "Amyloid beta clearance by transcytosis", "Amyloid beta formation", "Amyloid beta metabolic process", "Amyloid fibril formation", "Amyloid precursor protein biosynthetic process", "Amyloid precursor protein catabolic process", "Amyloid precursor protein metabolic process", "Anagen", "Anaphase promoting complex dependent catabolic process", "Anatomical structure arrangement", "Anatomical structure formation involved in morphogenesis", "Anatomical structure homeostasis", "Anatomical structure maturation", "Androgen biosynthetic process", "Androgen catabolic process", "Androgen metabolic process", "Androgen receptor signaling pathway", "Angiogenesis involved in coronary vascular morphogenesis", "Angiogenesis involved in wound healing", "Angiotensin activated signaling pathway", "Animal organ formation", "Animal organ morphogenesis", "Animal organ regeneration", "Anion homeostasis", "Anion transmembrane transport", "Anion transport", "Anoikis", "Anterior head development", "Anterior posterior axis specification", "Anterior posterior pattern specification", "Anterograde axonal transport", "Anterograde axonal transport of mitochondrion", "Anterograde dendritic transport", "Anterograde dendritic transport of neurotransmitter receptor complex", "Anterograde neuronal dense core vesicle transport", "Antibacterial humoral response", "Antigen processing and presentation", "Antigen processing and presentation of endogenous antigen", "Antigen processing and presentation of endogenous peptide antigen", "Antigen processing and presentation of endogenous peptide antigen via mhc class i via er pathway", "Antigen processing and presentation of exogenous antigen", "Antigen processing and presentation of exogenous peptide antigen", "Antigen processing and presentation of exogenous peptide antigen via mhc class i", "Antigen processing and presentation of exogenous peptide antigen via mhc class ii", "Antigen processing and presentation of lipid antigen via mhc class ib", "Antigen processing and presentation of peptide antigen", "Antigen processing and presentation of peptide antigen via mhc class i", "Antigen processing and presentation of peptide or polysaccharide antigen via mhc class ii", "Antigen processing and presentation via mhc class ib", "Antigen receptor mediated signaling pathway", "Antimicrobial humoral immune response mediated by antimicrobial peptide", "Antimicrobial humoral response", "Antiviral innate immune response", "Aorta development", "Aorta morphogenesis", "Aortic valve morphogenesis", "Apical junction assembly", "Apical protein localization", "Apoptotic cell clearance", "Apoptotic chromosome condensation", "Apoptotic dna fragmentation", "Apoptotic mitochondrial changes", "Apoptotic process involved in development", "Apoptotic process involved in morphogenesis", "Apoptotic signaling pathway", "Appendage development", "Appendage morphogenesis", "Arachidonic acid metabolic process", "Arachidonic acid secretion", "Arf protein signal transduction", "Arginine catabolic process", "Arginine metabolic process", "Aromatic amino acid family catabolic process", "Aromatic amino acid family metabolic process", "Aromatic amino acid transport", "Arp2 3 complex mediated actin nucleation", "Artery development", "Artery morphogenesis", "Asparagine metabolic process", "Aspartate family amino acid biosynthetic process", "Aspartate family amino acid catabolic process", "Aspartate family amino acid metabolic process", "Aspartate metabolic process", "Aspartate transmembrane transport", "Associative learning", "Astral microtubule organization", "Astrocyte activation", "Astrocyte cell migration", "Astrocyte development", "Astrocyte differentiation", "Asymmetric cell division", "Asymmetric neuroblast division", "Atf6 mediated unfolded protein response", "Atp biosynthetic process", "Atp metabolic process", "Atp synthesis coupled electron transport", "Atp synthesis coupled proton transport", "Atp transport", "Atrial cardiac muscle cell membrane repolarization", "Atrial cardiac muscle cell to av node cell signaling", "Atrial septum development", "Atrial septum morphogenesis", "Atrioventricular canal development", "Attachment of gpi anchor to protein", "Attachment of mitotic spindle microtubules to kinetochore", "Attachment of spindle microtubules to kinetochore", "Auditory receptor cell development", "Auditory receptor cell morphogenesis", "Autonomic nervous system development", "Autophagic cell death", "Autophagosome maturation", "Autophagosome membrane docking", "Autophagosome organization", "Autophagy of mitochondrion", "Autophagy of nucleus", "Autophagy of peroxisome", "Av node cell to bundle of his cell communication", "Av node cell to bundle of his cell signaling", "Axial mesoderm development", "Axis elongation", "Axis specification", "Axo dendritic protein transport", "Axo dendritic transport", "Axon choice point recognition", "Axon development", "Axon ensheathment in central nervous system", "Axon extension", "Axon midline choice point recognition", "Axonal fasciculation", "Axonal transport", "Axonal transport of mitochondrion", "Axonemal dynein complex assembly", "Axoneme assembly", "Axonogenesis involved in innervation", "Azole transmembrane transport", "B cell activation", "B cell activation involved in immune response", "B cell apoptotic process", "B cell differentiation", "B cell homeostasis", "B cell lineage commitment", "B cell mediated immunity", "B cell proliferation", "B cell receptor signaling pathway", "Barbed end actin filament capping", "Base conversion or substitution editing", "Base excision repair", "Base excision repair ap site formation", "Base excision repair gap filling", "Basement membrane assembly", "Basement membrane organization", "Behavior", "Behavioral response to cocaine", "Behavioral response to ethanol", "Behavioral response to pain", "Benzene containing compound metabolic process", "Bergmann glial cell differentiation", "Bicarbonate transport", "Bile acid and bile salt transport", "Bile acid biosynthetic process", "Bile acid metabolic process", "Bile acid secretion", "Binding of sperm to zona pellucida", "Biological adhesion", "Biological phase", "Biological process involved in interaction with host", "Biological process involved in interaction with symbiont", "Biological process involved in interspecies interaction between organisms", "Biological process involved in intraspecies interaction between organisms", "Biological process involved in symbiotic interaction", "Biomineralization", "Blastocyst development", "Blastocyst formation", "Blastocyst growth", "Blastoderm segmentation", "Bleb assembly", "Blood vessel endothelial cell differentiation", "Blood vessel endothelial cell migration", "Blood vessel endothelial cell proliferation involved in sprouting angiogenesis", "Blood vessel maturation", "Blood vessel morphogenesis", "Blood vessel remodeling", "Body fluid secretion", "Body morphogenesis", "Bone cell development", "Bone development", "Bone growth", "Bone marrow development", "Bone mineralization", "Bone morphogenesis", "Bone remodeling", "Bone resorption", "Box c d snornp assembly", "Bradykinin catabolic process", "Brain derived neurotrophic factor receptor signaling pathway", "Brain morphogenesis", "Brainstem development", "Branch elongation of an epithelium", "Branched chain amino acid biosynthetic process", "Branched chain amino acid catabolic process", "Branched chain amino acid metabolic process", "Branched chain amino acid transport", "Branching involved in blood vessel morphogenesis", "Branching involved in labyrinthine layer morphogenesis", "Branching involved in mammary gland duct morphogenesis", "Branching involved in salivary gland morphogenesis", "Branching morphogenesis of a nerve", "Branching morphogenesis of an epithelial tube", "Branchiomotor neuron axon guidance", "Brown fat cell differentiation", "Bundle of his cell to purkinje myocyte communication", "Bundle of his cell to purkinje myocyte signaling", "C 5 methylation of cytosine", "C terminal protein amino acid modification", "C terminal protein lipidation", "C21 steroid hormone biosynthetic process", "C21 steroid hormone metabolic process", "C4 dicarboxylate transport", "Calcineurin mediated signaling", "Calcium dependent cell cell adhesion via plasma membrane cell adhesion molecules", "Calcium import into the mitochondrion", "Calcium ion export", "Calcium ion export across plasma membrane", "Calcium ion import", "Calcium ion import into sarcoplasmic reticulum", "Calcium ion regulated exocytosis", "Calcium ion regulated exocytosis of neurotransmitter", "Calcium ion transmembrane transport", "Calcium ion transmembrane transport via high voltage gated calcium channel", "Calcium ion transport", "Calcium ion transport into cytosol", "Calcium mediated signaling", "Calcium mediated signaling using intracellular calcium source", "Calmodulin dependent kinase signaling pathway", "Camera type eye development", "Camera type eye morphogenesis", "Camera type eye photoreceptor cell differentiation", "Camp mediated signaling", "Cannabinoid signaling pathway", "Canonical wnt signaling pathway", "Canonical wnt signaling pathway involved in heart development", "Canonical wnt signaling pathway involved in osteoblast differentiation", "Canonical wnt signaling pathway involved in regulation of cell proliferation", "Cap dependent translational initiation", "Carbohydrate biosynthetic process", "Carbohydrate catabolic process", "Carbohydrate derivative biosynthetic process", "Carbohydrate derivative catabolic process", "Carbohydrate derivative metabolic process", "Carbohydrate derivative transport", "Carbohydrate homeostasis", "Carbohydrate mediated signaling", "Carbohydrate metabolic process", "Carbohydrate phosphorylation", "Carbohydrate transmembrane transport", "Carbohydrate transport", "Carboxylic acid transport", "Cardiac atrium development", "Cardiac atrium morphogenesis", "Cardiac cell development", "Cardiac chamber development", "Cardiac chamber morphogenesis", "Cardiac conduction", "Cardiac conduction system development", "Cardiac epithelial to mesenchymal transition", "Cardiac muscle cell action potential", "Cardiac muscle cell action potential involved in contraction", "Cardiac muscle cell cardiac muscle cell adhesion", "Cardiac muscle cell contraction", "Cardiac muscle cell differentiation", "Cardiac muscle cell membrane repolarization", "Cardiac muscle cell proliferation", "Cardiac muscle contraction", "Cardiac muscle tissue development", "Cardiac muscle tissue morphogenesis", "Cardiac neural crest cell development involved in outflow tract morphogenesis", "Cardiac neural crest cell differentiation involved in heart development", "Cardiac neural crest cell migration involved in outflow tract morphogenesis", "Cardiac septum development", "Cardiac septum morphogenesis", "Cardiac ventricle development", "Cardiac ventricle morphogenesis", "Cardioblast differentiation", "Cardioblast proliferation", "Cardiocyte differentiation", "Cardiolipin acyl chain remodeling", "Cardiolipin biosynthetic process", "Cardiolipin metabolic process", "Carnitine metabolic process", "Carnitine transport", "Cartilage development", "Cartilage development involved in endochondral bone morphogenesis", "Catechol containing compound biosynthetic process", "Catechol containing compound catabolic process", "Catechol containing compound metabolic process", "Catecholamine uptake", "Catecholamine uptake involved in synaptic transmission", "Cation transmembrane transport", "Cation transport", "Caveola assembly", "Caveolin mediated endocytosis", "Cd4 positive alpha beta t cell activation", "Cd4 positive alpha beta t cell differentiation", "Cd4 positive or cd8 positive alpha beta t cell lineage commitment", "Cd40 signaling pathway", "Cd8 positive alpha beta t cell activation", "Cd8 positive alpha beta t cell proliferation", "Cdc42 protein signal transduction", "Cdp choline pathway", "Cdp diacylglycerol metabolic process", "Cell activation", "Cell activation involved in immune response", "Cell adhesion mediated by integrin", "Cell adhesion molecule production", "Cell aging", "Cell cell adhesion", "Cell cell adhesion mediated by cadherin", "Cell cell adhesion mediated by integrin", "Cell cell adhesion via plasma membrane adhesion molecules", "Cell cell junction assembly", "Cell cell junction maintenance", "Cell cell junction organization", "Cell cell recognition", "Cell cell signaling", "Cell cell signaling by wnt", "Cell cell signaling involved in cardiac conduction", "Cell chemotaxis", "Cell communication by electrical coupling", "Cell communication by electrical coupling involved in cardiac conduction", "Cell communication involved in cardiac conduction", "Cell cycle", "Cell cycle checkpoint signaling", "Cell cycle dna replication", "Cell cycle dna replication initiation", "Cell cycle g1 s phase transition", "Cell cycle g2 m phase transition", "Cell cycle phase transition", "Cell cycle process", "Cell death in response to hydrogen peroxide", "Cell death in response to oxidative stress", "Cell differentiation in hindbrain", "Cell differentiation in spinal cord", "Cell differentiation involved in embryonic placenta development", "Cell differentiation involved in kidney development", "Cell differentiation involved in metanephros development", "Cell differentiation involved in phenotypic switching", "Cell division", "Cell fate commitment", "Cell fate commitment involved in formation of primary germ layer", "Cell fate determination", "Cell fate specification", "Cell growth", "Cell junction assembly", "Cell junction disassembly", "Cell junction maintenance", "Cell junction organization", "Cell killing", "Cell matrix adhesion", "Cell maturation", "Cell migration", "Cell migration in hindbrain", "Cell migration involved in gastrulation", "Cell migration involved in heart development", "Cell migration involved in sprouting angiogenesis", "Cell morphogenesis", "Cell morphogenesis involved in differentiation", "Cell morphogenesis involved in neuron differentiation", "Cell motility involved in cerebral cortex radial glia guided migration", "Cell part morphogenesis", "Cell projection assembly", "Cell projection organization", "Cell proliferation in forebrain", "Cell proliferation in hindbrain", "Cell proliferation involved in heart morphogenesis", "Cell proliferation involved in kidney development", "Cell proliferation involved in metanephros development", "Cell recognition", "Cell redox homeostasis", "Cell substrate adhesion", "Cell substrate junction organization", "Cell surface receptor signaling pathway involved in cell cell signaling", "Cell surface receptor signaling pathway involved in heart development", "Cell volume homeostasis", "Cellular aldehyde metabolic process", "Cellular amide metabolic process", "Cellular amino acid biosynthetic process", "Cellular amino acid catabolic process", "Cellular amino acid metabolic process", "Cellular anion homeostasis", "Cellular carbohydrate biosynthetic process", "Cellular carbohydrate catabolic process", "Cellular carbohydrate metabolic process", "Cellular component assembly involved in morphogenesis", "Cellular component disassembly", "Cellular component disassembly involved in execution phase of apoptosis", "Cellular component maintenance", "Cellular component morphogenesis", "Cellular copper ion homeostasis", "Cellular defense response", "Cellular detoxification of aldehyde", "Cellular extravasation", "Cellular glucan metabolic process", "Cellular glucose homeostasis", "Cellular homeostasis", "Cellular hormone metabolic process", "Cellular hyperosmotic response", "Cellular hyperosmotic salinity response", "Cellular hypotonic response", "Cellular ion homeostasis", "Cellular iron ion homeostasis", "Cellular ketone metabolic process", "Cellular lipid catabolic process", "Cellular lipid metabolic process", "Cellular macromolecule biosynthetic process", "Cellular macromolecule localization", "Cellular metabolic compound salvage", "Cellular modified amino acid biosynthetic process", "Cellular modified amino acid catabolic process", "Cellular modified amino acid metabolic process", "Cellular monovalent inorganic anion homeostasis", "Cellular monovalent inorganic cation homeostasis", "Cellular nitrogen compound catabolic process", "Cellular oxidant detoxification", "Cellular pigmentation", "Cellular polysaccharide catabolic process", "Cellular potassium ion homeostasis", "Cellular process involved in reproduction in multicellular organism", "Cellular protein catabolic process", "Cellular respiration", "Cellular response to abiotic stimulus", "Cellular response to acid chemical", "Cellular response to acidic ph", "Cellular response to alcohol", "Cellular response to aldehyde", "Cellular response to amyloid beta", "Cellular response to antibiotic", "Cellular response to arsenic containing substance", "Cellular response to atp", "Cellular response to biotic stimulus", "Cellular response to brain derived neurotrophic factor stimulus", "Cellular response to cadmium ion", "Cellular response to calcium ion", "Cellular response to camp", "Cellular response to carbohydrate stimulus", "Cellular response to chemical stress", "Cellular response to cold", "Cellular response to copper ion", "Cellular response to corticosteroid stimulus", "Cellular response to dexamethasone stimulus", "Cellular response to dna damage stimulus", "Cellular response to dsrna", "Cellular response to electrical stimulus", "Cellular response to endogenous stimulus", "Cellular response to estradiol stimulus", "Cellular response to estrogen stimulus", "Cellular response to ethanol", "Cellular response to ether", "Cellular response to exogenous dsrna", "Cellular response to external stimulus", "Cellular response to extracellular stimulus", "Cellular response to fatty acid", "Cellular response to fluid shear stress", "Cellular response to follicle stimulating hormone stimulus", "Cellular response to gamma radiation", "Cellular response to glucose starvation", "Cellular response to gonadotropin stimulus", "Cellular response to growth hormone stimulus", "Cellular response to heat", "Cellular response to heparin", "Cellular response to histamine", "Cellular response to hormone stimulus", "Cellular response to hydrogen peroxide", "Cellular response to hydroperoxide", "Cellular response to hyperoxia", "Cellular response to increased oxygen levels", "Cellular response to indole 3 methanol", "Cellular response to inorganic substance", "Cellular response to insulin like growth factor stimulus", "Cellular response to insulin stimulus", "Cellular response to interferon alpha", "Cellular response to interferon beta", "Cellular response to interferon gamma", "Cellular response to interleukin 1", "Cellular response to ionizing radiation", "Cellular response to iron ion", "Cellular response to ketone", "Cellular response to leptin stimulus", "Cellular response to leucine", "Cellular response to leucine starvation", "Cellular response to light intensity", "Cellular response to light stimulus", "Cellular response to lipid", "Cellular response to lipoprotein particle stimulus", "Cellular response to lithium ion", "Cellular response to low density lipoprotein particle stimulus", "Cellular response to manganese ion", "Cellular response to mechanical stimulus", "Cellular response to mineralocorticoid stimulus", "Cellular response to molecule of bacterial origin", "Cellular response to muramyl dipeptide", "Cellular response to nicotine", "Cellular response to nitrogen compound", "Cellular response to nitrogen starvation", "Cellular response to nitrosative stress", "Cellular response to nutrient", "Cellular response to organic cyclic compound", "Cellular response to osmotic stress", "Cellular response to oxygen containing compound", "Cellular response to oxygen glucose deprivation", "Cellular response to oxygen levels", "Cellular response to oxygen radical", "Cellular response to peptide", "Cellular response to peptide hormone stimulus", "Cellular response to peptidoglycan", "Cellular response to ph", "Cellular response to potassium ion", "Cellular response to prostaglandin e stimulus", "Cellular response to prostaglandin stimulus", "Cellular response to radiation", "Cellular response to reactive nitrogen species", "Cellular response to reactive oxygen species", "Cellular response to retinoic acid", "Cellular response to salt", "Cellular response to salt stress", "Cellular response to sodium arsenite", "Cellular response to starvation", "Cellular response to steroid hormone stimulus", "Cellular response to sterol depletion", "Cellular response to stress", "Cellular response to testosterone stimulus", "Cellular response to thyroid hormone stimulus", "Cellular response to topologically incorrect protein", "Cellular response to toxic substance", "Cellular response to unfolded protein", "Cellular response to uv", "Cellular response to uv a", "Cellular response to uv c", "Cellular response to vascular endothelial growth factor stimulus", "Cellular response to virus", "Cellular response to vitamin", "Cellular response to vitamin d", "Cellular response to water stimulus", "Cellular response to x ray", "Cellular response to xenobiotic stimulus", "Cellular response to zinc ion", "Cellular senescence", "Cellular sodium ion homeostasis", "Cellular sphingolipid homeostasis", "Cellular transition metal ion homeostasis", "Cellular triglyceride homeostasis", "Cellular trivalent inorganic anion homeostasis", "Cenp a containing chromatin organization", "Central nervous system development", "Central nervous system maturation", "Central nervous system myelin formation", "Central nervous system neuron axonogenesis", "Central nervous system neuron development", "Central nervous system neuron differentiation", "Central nervous system projection neuron axonogenesis", "Centriole assembly", "Centriole centriole cohesion", "Centriole elongation", "Centromere complex assembly", "Centromeric sister chromatid cohesion", "Centrosome duplication", "Centrosome separation", "Ceramide 1 phosphate transport", "Ceramide biosynthetic process", "Ceramide catabolic process", "Ceramide metabolic process", "Ceramide transport", "Cerebellar cortex development", "Cerebellar cortex formation", "Cerebellar cortex morphogenesis", "Cerebellar granular layer development", "Cerebellar granular layer formation", "Cerebellar granular layer morphogenesis", "Cerebellar purkinje cell layer development", "Cerebellar purkinje cell layer formation", "Cerebellar purkinje cell layer morphogenesis", "Cerebral cortex cell migration", "Cerebral cortex development", "Cerebral cortex neuron differentiation", "Cerebral cortex radially oriented cell migration", "Cerebral cortex regionalization", "Cerebral cortex tangential migration", "Cerebrospinal fluid circulation", "Cgmp mediated signaling", "Changes to dna methylation involved in embryo development", "Chaperone cofactor dependent protein refolding", "Chaperone mediated autophagy", "Chaperone mediated protein complex assembly", "Chaperone mediated protein folding", "Chemical homeostasis", "Chemical homeostasis within a tissue", "Chemical synaptic transmission postsynaptic", "Chemokine c c motif ligand 5 production", "Chemokine c x c motif ligand 12 signaling pathway", "Chemokine c x c motif ligand 2 production", "Chemokine production", "Chemosensory behavior", "Chitin metabolic process", "Chloride transmembrane transport", "Chloride transport", "Cholesterol catabolic process", "Cholesterol efflux", "Cholesterol storage", "Choline metabolic process", "Chondrocyte development", "Chondrocyte development involved in endochondral bone morphogenesis", "Chondrocyte differentiation", "Chondrocyte differentiation involved in endochondral bone morphogenesis", "Chondrocyte proliferation", "Chondroitin sulfate biosynthetic process", "Chondroitin sulfate proteoglycan biosynthetic process", "Chondroitin sulfate proteoglycan metabolic process", "Chorion development", "Chromatin assembly or disassembly", "Chromatin disassembly", "Chromatin organization", "Chromatin remodeling", "Chromatin remodeling at centromere", "Chromosome attachment to the nuclear envelope", "Chromosome condensation", "Chromosome localization", "Chromosome localization to nuclear envelope involved in homologous chromosome segregation", "Chromosome movement towards spindle pole", "Chromosome organization", "Chromosome organization involved in meiotic cell cycle", "Chromosome segregation", "Chromosome separation", "Cilium movement", "Cilium or flagellum dependent cell motility", "Cilium organization", "Circadian regulation of gene expression", "Circadian rhythm", "Circulatory system development", "Circulatory system process", "Citrate metabolic process", "Citrulline biosynthetic process", "Citrulline metabolic process", "Clathrin coat assembly", "Clathrin dependent endocytosis", "Cleavage furrow formation", "Cleavage involved in rrna processing", "Cobalamin metabolic process", "Cobalt ion transport", "Cochlea development", "Cochlea morphogenesis", "Coenzyme a biosynthetic process", "Coenzyme a metabolic process", "Cognition", "Cohesin loading", "Collagen biosynthetic process", "Collagen catabolic process", "Collagen fibril organization", "Collagen metabolic process", "Collateral sprouting", "Collateral sprouting in absence of injury", "Collecting duct development", "Columnar cuboidal epithelial cell development", "Columnar cuboidal epithelial cell differentiation", "Columnar cuboidal epithelial cell maturation", "Commissural neuron axon guidance", "Common partner smad protein phosphorylation", "Complement activation", "Complement dependent cytotoxicity", "Connective tissue development", "Connective tissue replacement", "Constitutive heterochromatin assembly", "Constitutive secretory pathway", "Convergent extension", "Convergent extension involved in axis elongation", "Cop9 signalosome assembly", "Copi coated vesicle budding", "Copii coated vesicle budding", "Copii coated vesicle cargo loading", "Copper ion homeostasis", "Copper ion import", "Copper ion transmembrane transport", "Copper ion transport", "Coronary artery morphogenesis", "Coronary vasculature development", "Coronary vasculature morphogenesis", "Corpus callosum development", "Corpus callosum morphogenesis", "Cortical actin cytoskeleton organization", "Cortical cytoskeleton organization", "Corticospinal tract morphogenesis", "Corticosteroid hormone secretion", "Corticosteroid receptor signaling pathway", "Cortisol secretion", "Cotranslational protein targeting to membrane", "Cranial ganglion development", "Cranial nerve development", "Cranial nerve morphogenesis", "Cranial nerve structural organization", "Cranial skeletal system development", "Craniofacial suture morphogenesis", "Crd mediated mrna stabilization", "Cristae formation", "Cyclic nucleotide catabolic process", "Cyclic nucleotide mediated signaling", "Cyclic nucleotide metabolic process", "Cyclooxygenase pathway", "Cysteine metabolic process", "Cytochrome complex assembly", "Cytokine mediated signaling pathway", "Cytokine production", "Cytokine production involved in immune response", "Cytokine production involved in inflammatory response", "Cytokinesis", "Cytokinetic process", "Cytoplasm organization", "Cytoplasmic microtubule organization", "Cytoplasmic pattern recognition receptor signaling pathway", "Cytoplasmic pattern recognition receptor signaling pathway in response to virus", "Cytoplasmic sequestering of nf kappab", "Cytoplasmic sequestering of protein", "Cytoplasmic sequestering of transcription factor", "Cytoplasmic translation", "Cytoplasmic translational elongation", "Cytoplasmic translational initiation", "Cytoskeleton dependent cytokinesis", "Cytoskeleton dependent intracellular transport", "Cytoskeleton organization", "Cytosolic calcium ion transport", "Cytosolic transport", "D amino acid transport", "Damp metabolic process", "De novo amp biosynthetic process", "De novo protein folding", "De novo pyrimidine nucleobase biosynthetic process", "Deadenylation dependent decapping of nuclear transcribed mrna", "Decidualization", "Dedifferentiation", "Defense response", "Defense response to bacterium", "Defense response to fungus", "Defense response to gram negative bacterium", "Defense response to gram positive bacterium", "Defense response to other organism", "Defense response to symbiont", "Defense response to tumor cell", "Definitive erythrocyte differentiation", "Definitive hemopoiesis", "Delamination", "Demethylation", "Dendrite arborization", "Dendrite development", "Dendrite extension", "Dendrite morphogenesis", "Dendrite self avoidance", "Dendritic cell apoptotic process", "Dendritic cell chemotaxis", "Dendritic cell cytokine production", "Dendritic cell differentiation", "Dendritic cell migration", "Dendritic spine development", "Dendritic spine maintenance", "Dendritic spine morphogenesis", "Dendritic transport", "Dense core granule transport", "Dentate gyrus development", "Deoxyribonucleoside catabolic process", "Deoxyribonucleoside diphosphate metabolic process", "Deoxyribonucleoside metabolic process", "Deoxyribonucleoside monophosphate biosynthetic process", "Deoxyribonucleoside monophosphate catabolic process", "Deoxyribonucleoside monophosphate metabolic process", "Deoxyribonucleoside triphosphate biosynthetic process", "Deoxyribonucleoside triphosphate catabolic process", "Deoxyribonucleoside triphosphate metabolic process", "Deoxyribonucleotide biosynthetic process", "Deoxyribose phosphate catabolic process", "Deoxyribose phosphate metabolic process", "Dephosphorylation", "Dephosphorylation of rna polymerase ii c terminal domain", "Depyrimidination", "Dermatan sulfate biosynthetic process", "Dermatan sulfate metabolic process", "Dermatan sulfate proteoglycan metabolic process", "Desmosome organization", "Detection of abiotic stimulus", "Detection of biotic stimulus", "Detection of calcium ion", "Detection of cell density", "Detection of external biotic stimulus", "Detection of light stimulus", "Detection of mechanical stimulus", "Detection of molecule of bacterial origin", "Detection of muscle stretch", "Detection of other organism", "Detection of stimulus", "Detection of virus", "Detection of visible light", "Determination of adult lifespan", "Determination of dorsal ventral asymmetry", "Detoxification", "Detoxification of copper ion", "Detoxification of nitrogen compound", "Development of primary female sexual characteristics", "Development of primary sexual characteristics", "Development of secondary female sexual characteristics", "Development of secondary sexual characteristics", "Developmental cell growth", "Developmental growth", "Developmental growth involved in morphogenesis", "Developmental induction", "Developmental maturation", "Developmental pigmentation", "Developmental process involved in reproduction", "Diacylglycerol biosynthetic process", "Diacylglycerol metabolic process", "Diadenosine polyphosphate metabolic process", "Diapedesis", "Dicarboxylic acid biosynthetic process", "Dicarboxylic acid catabolic process", "Dicarboxylic acid metabolic process", "Dicarboxylic acid transport", "Dichotomous subdivision of an epithelial terminal unit", "Dichotomous subdivision of terminal units involved in salivary gland branching", "Diencephalon development", "Diet induced thermogenesis", "Digestion", "Digestive system development", "Digestive system process", "Digestive tract morphogenesis", "Diol biosynthetic process", "Diol metabolic process", "Disaccharide metabolic process", "Diterpenoid biosynthetic process", "Divalent inorganic cation homeostasis", "Dna biosynthetic process", "Dna catabolic process", "Dna catabolic process endonucleolytic", "Dna catabolic process exonucleolytic", "Dna conformation change", "Dna damage response signal transduction by p53 class mediator", "Dna damage response signal transduction by p53 class mediator resulting in cell cycle arrest", "Dna damage response signal transduction resulting in transcription", "Dna dealkylation", "Dna dealkylation involved in dna repair", "Dna deamination", "Dna dependent dna replication", "Dna dependent dna replication maintenance of fidelity", "Dna double strand break processing", "Dna endoreduplication", "Dna geometric change", "Dna integration", "Dna integrity checkpoint signaling", "Dna ligation", "Dna ligation involved in dna repair", "Dna metabolic process", "Dna methylation", "Dna methylation dependent heterochromatin assembly", "Dna methylation involved in gamete generation", "Dna methylation on cytosine", "Dna methylation or demethylation", "Dna modification", "Dna packaging", "Dna protection", "Dna recombination", "Dna repair", "Dna replication", "Dna replication checkpoint signaling", "Dna replication dependent chromatin organization", "Dna replication independent chromatin organization", "Dna replication initiation", "Dna replication synthesis of rna primer", "Dna strand elongation", "Dna strand elongation involved in dna replication", "Dna synthesis involved in dna repair", "Dna templated transcription elongation", "Dna templated transcription initiation", "Dna templated transcription termination", "Dna topological change", "Dna unwinding involved in dna replication", "Dolichol metabolic process", "Dopamine biosynthetic process", "Dopamine metabolic process", "Dopamine receptor signaling pathway", "Dopamine transport", "Dopaminergic neuron differentiation", "Dorsal root ganglion development", "Dorsal ventral axis specification", "Dorsal ventral neural tube patterning", "Dorsal ventral pattern formation", "Dosage compensation", "Double strand break repair", "Double strand break repair via break induced replication", "Double strand break repair via classical nonhomologous end joining", "Double strand break repair via nonhomologous end joining", "Dsrna processing", "Dtmp metabolic process", "Dttp metabolic process", "Dump metabolic process", "Ear development", "Ear morphogenesis", "Early endosome to golgi transport", "Eating behavior", "Ectoderm development", "Ectodermal placode development", "Ectopic germ cell programmed cell death", "Egg activation", "Electron transport chain", "Embryo development", "Embryo development ending in birth or egg hatching", "Embryo implantation", "Embryonic appendage morphogenesis", "Embryonic axis specification", "Embryonic body morphogenesis", "Embryonic brain development", "Embryonic camera type eye development", "Embryonic cleavage", "Embryonic cranial skeleton morphogenesis", "Embryonic digestive tract development", "Embryonic digestive tract morphogenesis", "Embryonic digit morphogenesis", "Embryonic forelimb morphogenesis", "Embryonic heart tube development", "Embryonic heart tube morphogenesis", "Embryonic hemopoiesis", "Embryonic hindlimb morphogenesis", "Embryonic morphogenesis", "Embryonic neurocranium morphogenesis", "Embryonic organ development", "Embryonic organ morphogenesis", "Embryonic pattern specification", "Embryonic placenta development", "Embryonic placenta morphogenesis", "Embryonic process involved in female pregnancy", "Embryonic skeletal joint development", "Embryonic skeletal joint morphogenesis", "Embryonic skeletal system development", "Embryonic skeletal system morphogenesis", "Embryonic viscerocranium morphogenesis", "Enamel mineralization", "Endocannabinoid signaling pathway", "Endochondral bone morphogenesis", "Endocrine hormone secretion", "Endocrine pancreas development", "Endocrine process", "Endocrine system development", "Endocytic recycling", "Endocytosis", "Endocytosis involved in viral entry into host cell", "Endoderm development", "Endoderm formation", "Endodermal cell differentiation", "Endodermal cell fate commitment", "Endomembrane system organization", "Endonucleolytic cleavage in 5 ets of tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna", "Endonucleolytic cleavage in its1 to separate ssu rrna from 5 8s rrna and lsu rrna from tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna", "Endonucleolytic cleavage involved in rrna processing", "Endoplasmic reticulum calcium ion homeostasis", "Endoplasmic reticulum localization", "Endoplasmic reticulum mannose trimming", "Endoplasmic reticulum membrane organization", "Endoplasmic reticulum organization", "Endoplasmic reticulum plasma membrane tethering", "Endoplasmic reticulum to cytosol transport", "Endoplasmic reticulum to golgi vesicle mediated transport", "Endoplasmic reticulum tubular network organization", "Endoplasmic reticulum unfolded protein response", "Endosomal lumen acidification", "Endosomal transport", "Endosomal vesicle fusion", "Endosome organization", "Endosome to lysosome transport", "Endosome to lysosome transport via multivesicular body sorting pathway", "Endosome to plasma membrane protein transport", "Endosome transport via multivesicular body sorting pathway", "Endothelial cell activation", "Endothelial cell apoptotic process", "Endothelial cell chemotaxis", "Endothelial cell development", "Endothelial cell fate commitment", "Endothelial cell migration", "Endothelial cell morphogenesis", "Endothelial cell proliferation", "Endothelin receptor signaling pathway", "Endothelium development", "Energy derivation by oxidation of organic compounds", "Energy homeostasis", "Energy reserve metabolic process", "Engulfment of apoptotic cell", "Ensheathment of neurons", "Enteroendocrine cell differentiation", "Entrainment of circadian clock", "Entry into host", "Entry of bacterium into host cell", "Enucleate erythrocyte differentiation", "Enzyme directed rrna pseudouridine synthesis", "Enzyme linked receptor protein signaling pathway", "Eosinophil activation", "Eosinophil chemotaxis", "Eosinophil mediated immunity", "Eosinophil migration", "Ephrin receptor signaling pathway", "Epiboly", "Epidermal cell differentiation", "Epidermis development", "Epidermis morphogenesis", "Epigenetic maintenance of chromatin in transcription competent conformation", "Epithelial cell apoptotic process", "Epithelial cell cell adhesion", "Epithelial cell development", "Epithelial cell differentiation", "Epithelial cell differentiation involved in kidney development", "Epithelial cell differentiation involved in prostate gland development", "Epithelial cell fate commitment", "Epithelial cell maturation", "Epithelial cell morphogenesis", "Epithelial cell proliferation", "Epithelial cell proliferation involved in lung morphogenesis", "Epithelial cell proliferation involved in prostate gland development", "Epithelial fluid transport", "Epithelial structure maintenance", "Epithelial to mesenchymal transition", "Epithelial tube branching involved in lung morphogenesis", "Epithelial tube formation", "Epithelial tube morphogenesis", "Epithelium development", "Epoxide metabolic process", "Er associated misfolded protein catabolic process", "Er nucleus signaling pathway", "Er overload response", "Erad pathway", "Erbb signaling pathway", "Erbb2 signaling pathway", "Erk1 and erk2 cascade", "Error free translesion synthesis", "Error prone translesion synthesis", "Erythrocyte development", "Erythrocyte homeostasis", "Erythrocyte maturation", "Escrt complex disassembly", "Establishment of cell polarity", "Establishment of centrosome localization", "Establishment of endothelial barrier", "Establishment of endothelial intestinal barrier", "Establishment of epithelial cell apical basal polarity", "Establishment of epithelial cell polarity", "Establishment of golgi localization", "Establishment of lymphocyte polarity", "Establishment of meiotic spindle localization", "Establishment of mitochondrion localization", "Establishment of mitotic spindle localization", "Establishment of organelle localization", "Establishment of pigment granule localization", "Establishment of planar polarity involved in neural tube closure", "Establishment of planar polarity of embryonic epithelium", "Establishment of protein localization", "Establishment of protein localization to chromatin", "Establishment of protein localization to chromosome", "Establishment of protein localization to endoplasmic reticulum", "Establishment of protein localization to membrane", "Establishment of protein localization to mitochondrial membrane", "Establishment of protein localization to organelle", "Establishment of protein localization to plasma membrane", "Establishment of protein localization to telomere", "Establishment of protein localization to vacuole", "Establishment of rna localization", "Establishment of sister chromatid cohesion", "Establishment of spindle orientation", "Establishment of tissue polarity", "Establishment or maintenance of bipolar cell polarity", "Establishment or maintenance of cell polarity", "Establishment or maintenance of cytoskeleton polarity", "Establishment or maintenance of monopolar cell polarity", "Establishment or maintenance of transmembrane electrochemical gradient", "Estrogen biosynthetic process", "Estrogen metabolic process", "Estrous cycle", "Ethanol catabolic process", "Ethanol metabolic process", "Ethanol oxidation", "Ethanolamine containing compound metabolic process", "Ether biosynthetic process", "Ether metabolic process", "Excretion", "Execution phase of apoptosis", "Exit from mitosis", "Exocrine pancreas development", "Exocrine system development", "Exocyst localization", "Exocytic process", "Exocytosis", "Exonucleolytic catabolism of deadenylated mrna", "Exploration behavior", "Export across plasma membrane", "Export from cell", "External encapsulating structure organization", "Extracellular exosome assembly", "Extracellular matrix assembly", "Extracellular matrix disassembly", "Extracellular transport", "Extracellular vesicle biogenesis", "Extraembryonic membrane development", "Extrinsic apoptotic signaling pathway", "Extrinsic apoptotic signaling pathway via death domain receptors", "Eye morphogenesis", "Eye photoreceptor cell development", "Eye photoreceptor cell differentiation", "Eye pigmentation", "Eyelid development in camera type eye", "Face development", "Facial nerve morphogenesis", "Facial nerve structural organization", "Facultative heterochromatin assembly", "Farnesyl diphosphate metabolic process", "Fas signaling pathway", "Fat cell differentiation", "Fat cell proliferation", "Fat soluble vitamin metabolic process", "Fatty acid alpha oxidation", "Fatty acid beta oxidation", "Fatty acid beta oxidation using acyl coa dehydrogenase", "Fatty acid beta oxidation using acyl coa oxidase", "Fatty acid biosynthetic process", "Fatty acid catabolic process", "Fatty acid derivative biosynthetic process", "Fatty acid derivative catabolic process", "Fatty acid derivative metabolic process", "Fatty acid elongation", "Fatty acid homeostasis", "Fatty acid metabolic process", "Fatty acid omega oxidation", "Fatty acid transmembrane transport", "Fatty acid transport", "Fatty acyl coa biosynthetic process", "Fatty acyl coa catabolic process", "Fatty acyl coa metabolic process", "Fc epsilon receptor signaling pathway", "Fc gamma receptor signaling pathway", "Fc receptor mediated stimulatory signaling pathway", "Fc receptor signaling pathway", "Fear response", "Feeding behavior", "Female gamete generation", "Female meiosis chromosome segregation", "Female meiosis i", "Female meiotic nuclear division", "Female sex differentiation", "Fermentation", "Fertilization", "Fibroblast activation", "Fibroblast apoptotic process", "Fibroblast growth factor production", "Fibroblast growth factor receptor signaling pathway", "Fibroblast migration", "Fibroblast proliferation", "Filopodium assembly", "Flavin containing compound metabolic process", "Flavonoid metabolic process", "Fluid transport", "Foam cell differentiation", "Focal adhesion assembly", "Folate transmembrane transport", "Folic acid containing compound biosynthetic process", "Folic acid containing compound catabolic process", "Folic acid containing compound metabolic process", "Folic acid metabolic process", "Folic acid transport", "Forebrain cell migration", "Forebrain development", "Forebrain generation of neurons", "Forebrain morphogenesis", "Forebrain neuron development", "Forebrain neuron differentiation", "Forebrain regionalization", "Foregut morphogenesis", "Forelimb morphogenesis", "Formate metabolic process", "Formation of extrachromosomal circular dna", "Formation of primary germ layer", "Formation of translation preinitiation complex", "Free ubiquitin chain polymerization", "Fructose 1 6 bisphosphate metabolic process", "Fructose 2 6 bisphosphate metabolic process", "Fructose 6 phosphate metabolic process", "Fructose metabolic process", "Fucose metabolic process", "Fungiform papilla development", "Fungiform papilla morphogenesis", "G protein coupled acetylcholine receptor signaling pathway", "G protein coupled opioid receptor signaling pathway", "G protein coupled purinergic receptor signaling pathway", "G protein coupled receptor internalization", "G protein coupled receptor signaling pathway", "G protein coupled receptor signaling pathway coupled to cyclic nucleotide second messenger", "G protein coupled receptor signaling pathway involved in heart process", "G quadruplex dna unwinding", "G0 to g1 transition", "G1 to g0 transition", "G2 mi transition of meiotic cell cycle", "Galactose catabolic process", "Galactose metabolic process", "Gamete generation", "Gamma aminobutyric acid metabolic process", "Gamma aminobutyric acid signaling pathway", "Gamma aminobutyric acid transport", "Gamma delta t cell activation", "Ganglion development", "Ganglioside catabolic process", "Ganglioside metabolic process", "Gap junction assembly", "Gap junction mediated intercellular transport", "Gas homeostasis", "Gastrulation", "Gastrulation with mouth forming second", "Gdp mannose metabolic process", "Gdp metabolic process", "Gene silencing by rna", "Generation of precursor metabolites and energy", "Genitalia development", "Genitalia morphogenesis", "Genomic imprinting", "Germ cell development", "Germ cell migration", "Germ cell proliferation", "Gland development", "Gland morphogenesis", "Glandular epithelial cell development", "Glandular epithelial cell differentiation", "Glial cell apoptotic process", "Glial cell development", "Glial cell differentiation", "Glial cell fate commitment", "Glial cell migration", "Glial cell proliferation", "Gliogenesis", "Glomerular epithelial cell development", "Glomerular epithelial cell differentiation", "Glomerular epithelium development", "Glomerular visceral epithelial cell migration", "Glomerulus development", "Glucan biosynthetic process", "Glucocorticoid biosynthetic process", "Glucocorticoid metabolic process", "Glucocorticoid secretion", "Glucosamine containing compound catabolic process", "Glucosamine containing compound metabolic process", "Glucose 6 phosphate metabolic process", "Glucose catabolic process", "Glucose import", "Glucose import in response to insulin stimulus", "Glucose metabolic process", "Glucosylceramide metabolic process", "Glutamate biosynthetic process", "Glutamate catabolic process", "Glutamate homeostasis", "Glutamate metabolic process", "Glutamate receptor signaling pathway", "Glutamate reuptake", "Glutamine family amino acid biosynthetic process", "Glutamine family amino acid catabolic process", "Glutamine family amino acid metabolic process", "Glutamine metabolic process", "Glutamine transport", "Glutathione catabolic process", "Glutathione metabolic process", "Glycerol 3 phosphate metabolic process", "Glycerol ether metabolic process", "Glycerolipid biosynthetic process", "Glycerolipid catabolic process", "Glycerolipid metabolic process", "Glycerophospholipid biosynthetic process", "Glycerophospholipid catabolic process", "Glycerophospholipid metabolic process", "Glycine biosynthetic process", "Glycine metabolic process", "Glycolipid biosynthetic process", "Glycolipid catabolic process", "Glycolipid transport", "Glycolytic fermentation", "Glycolytic process through fructose 6 phosphate", "Glycoprotein biosynthetic process", "Glycoprotein catabolic process", "Glycoprotein metabolic process", "Glycosaminoglycan catabolic process", "Glycoside catabolic process", "Glycoside metabolic process", "Glycosphingolipid biosynthetic process", "Glycosphingolipid metabolic process", "Glycosyl compound biosynthetic process", "Glycosyl compound catabolic process", "Glycosyl compound metabolic process", "Glycosylation", "Glycosylceramide biosynthetic process", "Glycosylceramide catabolic process", "Glycosylceramide metabolic process", "Glyoxylate metabolic process", "Gmp biosynthetic process", "Gmp metabolic process", "Gmp salvage", "Golgi disassembly", "Golgi localization", "Golgi organization", "Golgi ribbon formation", "Golgi to endosome transport", "Golgi to lysosome transport", "Golgi to plasma membrane protein transport", "Golgi to plasma membrane transport", "Golgi to vacuole transport", "Golgi vesicle budding", "Golgi vesicle transport", "Gonadotropin secretion", "Gpi anchor metabolic process", "Granulocyte activation", "Granulocyte chemotaxis", "Granulocyte differentiation", "Granulocyte migration", "Granzyme mediated programmed cell death signaling pathway", "Grooming behavior", "Growth", "Growth hormone receptor signaling pathway via jak stat", "Growth hormone secretion", "Growth plate cartilage chondrocyte differentiation", "Growth plate cartilage development", "Gtp biosynthetic process", "Gtp metabolic process", "Guanine metabolic process", "Hair cell differentiation", "Hair cycle phase", "Hair follicle maturation", "Hair follicle placode formation", "Head development", "Head morphogenesis", "Heart development", "Heart formation", "Heart growth", "Heart morphogenesis", "Heart process", "Heart trabecula formation", "Heart trabecula morphogenesis", "Heart valve development", "Heart valve morphogenesis", "Heat acclimation", "Hematopoietic progenitor cell differentiation", "Hematopoietic stem cell differentiation", "Hematopoietic stem cell homeostasis", "Hematopoietic stem cell proliferation", "Heme transport", "Hemidesmosome assembly", "Hemoglobin biosynthetic process", "Hemoglobin metabolic process", "Hemostasis", "Heparan sulfate proteoglycan biosynthetic process", "Heparan sulfate proteoglycan metabolic process", "Hepatic stellate cell activation", "Hepaticobiliary system development", "Hepatocyte apoptotic process", "Hepatocyte differentiation", "Hepatocyte growth factor receptor signaling pathway", "Heterochromatin organization", "Heterophilic cell cell adhesion via plasma membrane cell adhesion molecules", "Heterotypic cell cell adhesion", "High density lipoprotein particle clearance", "High density lipoprotein particle remodeling", "Hindbrain development", "Hindbrain maturation", "Hindbrain morphogenesis", "Hindbrain radial glia guided cell migration", "Hindlimb morphogenesis", "Hippo signaling", "Hippocampus development", "His purkinje system development", "Histamine production involved in inflammatory response", "Histamine secretion", "Histamine transport", "Histidine metabolic process", "Histone arginine methylation", "Histone deacetylation", "Histone dephosphorylation", "Histone deubiquitination", "Histone exchange", "Histone h2a acetylation", "Histone h2a k119 monoubiquitination", "Histone h2a k63 linked ubiquitination", "Histone h2a monoubiquitination", "Histone h2a phosphorylation", "Histone h2a ubiquitination", "Histone h2b ubiquitination", "Histone h3 acetylation", "Histone h3 deacetylation", "Histone h3 k14 acetylation", "Histone h3 k27 demethylation", "Histone h3 k27 methylation", "Histone h3 k27 trimethylation", "Histone h3 k36 demethylation", "Histone h3 k36 methylation", "Histone h3 k4 demethylation", "Histone h3 k4 demethylation trimethyl h3 k4 specific", "Histone h3 k4 dimethylation", "Histone h3 k4 methylation", "Histone h3 k4 monomethylation", "Histone h3 k4 trimethylation", "Histone h3 k9 acetylation", "Histone h3 k9 demethylation", "Histone h3 k9 dimethylation", "Histone h3 k9 methylation", "Histone h3 k9 modification", "Histone h3 k9 trimethylation", "Histone h4 acetylation", "Histone h4 deacetylation", "Histone h4 k16 acetylation", "Histone h4 k20 methylation", "Histone h4 k20 trimethylation", "Histone h4 k5 acetylation", "Histone h4 r3 methylation", "Histone lysine demethylation", "Histone methylation", "Histone modification", "Histone monoubiquitination", "Histone mrna catabolic process", "Histone mrna metabolic process", "Histone phosphorylation", "Histone serine phosphorylation", "Histone threonine phosphorylation", "Histone ubiquitination", "Homeostasis of number of cells", "Homeostasis of number of cells within a tissue", "Homeostatic process", "Homocysteine metabolic process", "Homologous chromosome pairing at meiosis", "Homologous chromosome segregation", "Homologous recombination", "Homophilic cell adhesion via plasma membrane adhesion molecules", "Homotypic cell cell adhesion", "Hormone biosynthetic process", "Hormone catabolic process", "Hormone mediated signaling pathway", "Hormone metabolic process", "Hormone transport", "Humoral immune response", "Humoral immune response mediated by circulating immunoglobulin", "Hyaluronan biosynthetic process", "Hyaluronan metabolic process", "Hydrogen peroxide biosynthetic process", "Hydrogen peroxide catabolic process", "Hydrogen peroxide metabolic process", "Hydrogen sulfide biosynthetic process", "Hydrogen sulfide metabolic process", "Hyperosmotic response", "Hyperosmotic salinity response", "Hypothalamus cell differentiation", "Hypothalamus cell migration", "Hypothalamus development", "Hypothalamus gonadotrophin releasing hormone neuron differentiation", "Hypotonic response", "Hypoxia inducible factor 1alpha signaling pathway", "I kappab kinase nf kappab signaling", "I kappab phosphorylation", "Icosanoid biosynthetic process", "Icosanoid metabolic process", "Icosanoid transport", "Immune effector process", "Immune response", "Immune response regulating cell surface receptor signaling pathway", "Immune response regulating signaling pathway", "Immune response to tumor cell", "Immune system development", "Immunoglobulin production", "Immunoglobulin production involved in immunoglobulin mediated immune response", "Immunoglobulin v d j recombination", "Immunological synapse formation", "Imp biosynthetic process", "Imp catabolic process", "Imp metabolic process", "Imp salvage", "Import across plasma membrane", "Import into cell", "Import into nucleus", "In utero embryonic development", "Inclusion body assembly", "Indolalkylamine metabolic process", "Indole containing compound biosynthetic process", "Indole containing compound metabolic process", "Inflammasome complex assembly", "Inflammatory cell apoptotic process", "Inflammatory response", "Inflammatory response to antigenic stimulus", "Inflammatory response to wounding", "Innate immune response", "Innate immune response activating signal transduction", "Innate immune response in mucosa", "Inner cell mass cell differentiation", "Inner cell mass cell proliferation", "Inner dynein arm assembly", "Inner ear auditory receptor cell differentiation", "Inner ear morphogenesis", "Inner ear receptor cell development", "Inner ear receptor cell stereocilium organization", "Inner mitochondrial membrane organization", "Innervation", "Inorganic anion transmembrane transport", "Inorganic anion transport", "Inorganic ion import across plasma membrane", "Inorganic ion transmembrane transport", "Inosine metabolic process", "Inositol lipid mediated signaling", "Inositol metabolic process", "Inositol phosphate catabolic process", "Inositol phosphate mediated signaling", "Inositol phosphate metabolic process", "Insulin like growth factor receptor signaling pathway", "Insulin metabolic process", "Insulin processing", "Insulin receptor signaling pathway", "Insulin secretion", "Insulin secretion involved in cellular response to glucose stimulus", "Integrated stress response signaling", "Integrin activation", "Integrin mediated signaling pathway", "Intercellular transport", "Interferon alpha production", "Interferon beta production", "Interferon gamma mediated signaling pathway", "Interferon gamma production", "Interleukin 1 alpha production", "Interleukin 1 mediated signaling pathway", "Interleukin 1 production", "Interleukin 10 production", "Interleukin 12 production", "Interleukin 17 production", "Interleukin 18 production", "Interleukin 2 production", "Interleukin 23 production", "Interleukin 27 mediated signaling pathway", "Interleukin 6 mediated signaling pathway", "Interleukin 6 production", "Interleukin 8 production", "Intermediate filament based process", "Intermediate filament bundle assembly", "Intermediate filament organization", "Intermembrane lipid transfer", "Interstrand cross link repair", "Intestinal absorption", "Intestinal epithelial cell development", "Intestinal epithelial cell differentiation", "Intestinal hexose absorption", "Intestinal lipid absorption", "Intra golgi vesicle mediated transport", "Intracellular distribution of mitochondria", "Intracellular estrogen receptor signaling pathway", "Intracellular lipid transport", "Intracellular mrna localization", "Intracellular protein transmembrane transport", "Intracellular protein transport", "Intracellular receptor signaling pathway", "Intracellular sterol transport", "Intracellular transport", "Intracellular transport of virus", "Intraciliary retrograde transport", "Intraciliary transport", "Intraciliary transport involved in cilium assembly", "Intrinsic apoptotic signaling pathway", "Intrinsic apoptotic signaling pathway by p53 class mediator", "Intrinsic apoptotic signaling pathway in response to dna damage", "Intrinsic apoptotic signaling pathway in response to dna damage by p53 class mediator", "Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress", "Intrinsic apoptotic signaling pathway in response to hydrogen peroxide", "Intrinsic apoptotic signaling pathway in response to hypoxia", "Intrinsic apoptotic signaling pathway in response to osmotic stress", "Intrinsic apoptotic signaling pathway in response to oxidative stress", "Ion homeostasis", "Ion transmembrane transport", "Ion transport", "Ire1 mediated unfolded protein response", "Ires dependent viral translational initiation", "Iron coordination entity transport", "Iron import into cell", "Iron ion homeostasis", "Iron ion import across plasma membrane", "Iron ion transmembrane transport", "Iron ion transport", "Iron sulfur cluster assembly", "Isocitrate metabolic process", "Isoleucine metabolic process", "Isopentenyl diphosphate biosynthetic process", "Isoprenoid biosynthetic process", "Isoprenoid metabolic process", "Isotype switching to iga isotypes", "Isotype switching to igg isotypes", "Jnk cascade", "Keratan sulfate metabolic process", "Keratinization", "Keratinocyte development", "Keratinocyte differentiation", "Keratinocyte migration", "Keratinocyte proliferation", "Ketone biosynthetic process", "Ketone body metabolic process", "Ketone catabolic process", "Kidney epithelium development", "Kidney mesenchyme development", "Kidney morphogenesis", "Killing by host of symbiont cells", "Killing of cells of another organism", "Kinetochore assembly", "Kinetochore organization", "Kynurenine metabolic process", "L alanine transport", "L alpha amino acid transmembrane transport", "L amino acid transport", "L ascorbic acid metabolic process", "L aspartate transmembrane transport", "L glutamate import across plasma membrane", "L glutamate transmembrane transport", "L kynurenine metabolic process", "L methionine salvage from methylthioadenosine", "L phenylalanine metabolic process", "L proline biosynthetic process", "L serine biosynthetic process", "L serine catabolic process", "L serine metabolic process", "L serine transport", "Labyrinthine layer blood vessel development", "Labyrinthine layer development", "Labyrinthine layer morphogenesis", "Lactate metabolic process", "Lactate transmembrane transport", "Lactation", "Lamellipodium assembly", "Lamellipodium morphogenesis", "Lamellipodium organization", "Late endosome to golgi transport", "Late endosome to lysosome transport", "Late endosome to vacuole transport", "Late endosome to vacuole transport via multivesicular body sorting pathway", "Lateral ventricle development", "Layer formation in cerebral cortex", "Learning", "Left right axis specification", "Left right pattern formation", "Lens development in camera type eye", "Lens fiber cell development", "Lens fiber cell differentiation", "Lens morphogenesis in camera type eye", "Leptin mediated signaling pathway", "Leucine catabolic process", "Leucine import across plasma membrane", "Leucine metabolic process", "Leucine transport", "Leukocyte adhesion to vascular endothelial cell", "Leukocyte aggregation", "Leukocyte apoptotic process", "Leukocyte cell cell adhesion", "Leukocyte chemotaxis", "Leukocyte degranulation", "Leukocyte differentiation", "Leukocyte homeostasis", "Leukocyte mediated cytotoxicity", "Leukocyte mediated immunity", "Leukocyte migration", "Leukocyte proliferation", "Leukocyte tethering or rolling", "Leukotriene b4 metabolic process", "Leukotriene biosynthetic process", "Leukotriene metabolic process", "Leydig cell differentiation", "Ligand gated ion channel signaling pathway", "Limb joint morphogenesis", "Limbic system development", "Lipid biosynthetic process", "Lipid catabolic process", "Lipid digestion", "Lipid droplet formation", "Lipid droplet organization", "Lipid export from cell", "Lipid glycosylation", "Lipid homeostasis", "Lipid import into cell", "Lipid localization", "Lipid metabolic process", "Lipid modification", "Lipid oxidation", "Lipid phosphorylation", "Lipid storage", "Lipid translocation", "Lipid transport across blood brain barrier", "Lipophagy", "Lipopolysaccharide mediated signaling pathway", "Lipoprotein biosynthetic process", "Lipoprotein catabolic process", "Lipoprotein localization", "Lipoprotein metabolic process", "Liposaccharide metabolic process", "Lipoxin metabolic process", "Liver morphogenesis", "Liver regeneration", "Localization within membrane", "Locomotion", "Locomotion involved in locomotory behavior", "Locomotor rhythm", "Locomotory behavior", "Locomotory exploration behavior", "Long chain fatty acid biosynthetic process", "Long chain fatty acid import across plasma membrane", "Long chain fatty acid metabolic process", "Long chain fatty acid transport", "Long chain fatty acyl coa biosynthetic process", "Long chain fatty acyl coa metabolic process", "Long term memory", "Long term synaptic depression", "Long term synaptic potentiation", "Low density lipoprotein particle clearance", "Low density lipoprotein receptor particle metabolic process", "Lung alveolus development", "Lung associated mesenchyme development", "Lung cell differentiation", "Lung epithelium development", "Lung lobe development", "Lung morphogenesis", "Lung saccule development", "Lung secretory cell differentiation", "Luteinization", "Luteolysis", "Lymphocyte activation", "Lymphocyte activation involved in immune response", "Lymphocyte aggregation", "Lymphocyte anergy", "Lymphocyte apoptotic process", "Lymphocyte chemotaxis", "Lymphocyte costimulation", "Lymphocyte homeostasis", "Lymphocyte mediated immunity", "Lymphocyte migration", "Lymphoid progenitor cell differentiation", "Lysine catabolic process", "Lysine metabolic process", "Lysosomal lumen acidification", "Lysosomal membrane organization", "Lysosomal protein catabolic process", "Lysosomal transport", "Lytic vacuole organization", "Macroautophagy", "Macromolecule catabolic process", "Macromolecule deacylation", "Macromolecule depalmitoylation", "Macrophage activation", "Macrophage apoptotic process", "Macrophage chemotaxis", "Macrophage differentiation", "Macrophage migration", "Macrophage proliferation", "Macropinocytosis", "Magnesium ion homeostasis", "Magnesium ion transport", "Maintenance of apical basal cell polarity", "Maintenance of blood brain barrier", "Maintenance of cell number", "Maintenance of cell polarity", "Maintenance of centrosome location", "Maintenance of dna methylation", "Maintenance of dna repeat elements", "Maintenance of gastrointestinal epithelium", "Maintenance of location", "Maintenance of location in cell", "Maintenance of organelle location", "Maintenance of postsynaptic specialization structure", "Maintenance of presynaptic active zone structure", "Maintenance of protein localization in endoplasmic reticulum", "Maintenance of protein localization in organelle", "Maintenance of protein location", "Maintenance of protein location in cell", "Maintenance of protein location in mitochondrion", "Maintenance of protein location in nucleus", "Maintenance of sister chromatid cohesion", "Maintenance of synapse structure", "Malate metabolic process", "Male gamete generation", "Male genitalia development", "Male mating behavior", "Male meiosis i", "Male meiotic nuclear division", "Male sex determination", "Male sex differentiation", "Malonyl coa metabolic process", "Mammalian oogenesis stage", "Mammary gland alveolus development", "Mammary gland branching involved in pregnancy", "Mammary gland development", "Mammary gland duct morphogenesis", "Mammary gland epithelial cell differentiation", "Mammary gland epithelial cell proliferation", "Mammary gland epithelium development", "Mammary gland involution", "Mammary gland morphogenesis", "Manganese ion transmembrane transport", "Manganese ion transport", "Mannose metabolic process", "Mannosylation", "Mapk cascade", "Mast cell activation", "Mast cell activation involved in immune response", "Mast cell cytokine production", "Maternal placenta development", "Maternal process involved in female pregnancy", "Mating", "Mating behavior", "Maturation of 5 8s rrna", "Maturation of 5 8s rrna from tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna", "Maturation of lsu rrna", "Maturation of lsu rrna from tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna", "Maturation of ssu rrna", "Maturation of ssu rrna from tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna", "Mature ribosome assembly", "Mda 5 signaling pathway", "Mechanoreceptor differentiation", "Mechanosensory behavior", "Medium chain fatty acid biosynthetic process", "Medium chain fatty acid catabolic process", "Medium chain fatty acid metabolic process", "Medium chain fatty acyl coa metabolic process", "Megakaryocyte development", "Megakaryocyte differentiation", "Meiosis i cell cycle process", "Meiosis ii cell cycle process", "Meiotic cell cycle", "Meiotic cell cycle checkpoint signaling", "Meiotic cell cycle phase transition", "Meiotic cell cycle process", "Meiotic chromosome condensation", "Meiotic chromosome segregation", "Meiotic chromosome separation", "Meiotic cytokinesis", "Meiotic dna double strand break formation", "Meiotic sister chromatid cohesion centromeric", "Meiotic spindle assembly", "Meiotic spindle organization", "Membrane biogenesis", "Membrane depolarization", "Membrane depolarization during action potential", "Membrane depolarization during cardiac muscle cell action potential", "Membrane disassembly", "Membrane docking", "Membrane fission", "Membrane fusion", "Membrane hyperpolarization", "Membrane invagination", "Membrane lipid biosynthetic process", "Membrane lipid catabolic process", "Membrane lipid metabolic process", "Membrane organization", "Membrane protein ectodomain proteolysis", "Membrane protein intracellular domain proteolysis", "Membrane protein proteolysis", "Membrane raft assembly", "Membrane raft localization", "Membrane raft organization", "Membrane repolarization", "Membrane repolarization during action potential", "Membrane repolarization during atrial cardiac muscle cell action potential", "Membrane repolarization during cardiac muscle cell action potential", "Membrane to membrane docking", "Membranous septum morphogenesis", "Memory", "Mesangial cell development", "Mesangial cell differentiation", "Mesenchymal cell development", "Mesenchymal cell differentiation", "Mesenchymal cell differentiation involved in kidney development", "Mesenchymal cell proliferation", "Mesenchymal cell proliferation involved in lung development", "Mesenchymal stem cell differentiation", "Mesenchymal to epithelial transition", "Mesenchymal to epithelial transition involved in metanephros morphogenesis", "Mesenchyme development", "Mesenchyme morphogenesis", "Mesoderm development", "Mesoderm morphogenesis", "Mesodermal cell differentiation", "Mesonephric duct development", "Mesonephric tubule formation", "Mesonephric tubule morphogenesis", "Mesonephros development", "Metal ion export", "Metal ion homeostasis", "Metal ion transport", "Metanephric collecting duct development", "Metanephric epithelium development", "Metanephric glomerulus development", "Metanephric glomerulus vasculature development", "Metanephric mesenchymal cell differentiation", "Metanephric mesenchyme development", "Metanephric nephron development", "Metanephric nephron morphogenesis", "Metanephric nephron tubule epithelial cell differentiation", "Metanephric renal vesicle morphogenesis", "Metanephric tubule development", "Metanephros development", "Metanephros morphogenesis", "Metaphase anaphase transition of cell cycle", "Metaphase plate congression", "Metencephalon development", "Methionine biosynthetic process", "Methionine metabolic process", "Methylation", "Methylglyoxal metabolic process", "Methylguanosine cap decapping", "Mhc class i biosynthetic process", "Mhc class ii biosynthetic process", "Microglia differentiation", "Microglial cell activation", "Microglial cell proliferation", "Microtubule anchoring", "Microtubule anchoring at centrosome", "Microtubule anchoring at microtubule organizing center", "Microtubule based movement", "Microtubule based process", "Microtubule based transport", "Microtubule bundle formation", "Microtubule cytoskeleton organization", "Microtubule cytoskeleton organization involved in mitosis", "Microtubule depolymerization", "Microtubule nucleation", "Microtubule organizing center localization", "Microtubule organizing center organization", "Microtubule polymerization", "Microtubule polymerization or depolymerization", "Microvillus assembly", "Microvillus organization", "Midbody abscission", "Midbrain development", "Midbrain dopaminergic neuron differentiation", "Middle ear morphogenesis", "Minus end directed organelle transport along microtubule", "Mirna catabolic process", "Mirna loading onto risc involved in gene silencing by mirna", "Mirna metabolic process", "Mismatch repair", "Mitochondrial acetyl coa biosynthetic process from pyruvate", "Mitochondrial adp transmembrane transport", "Mitochondrial atp synthesis coupled proton transport", "Mitochondrial calcium ion homeostasis", "Mitochondrial calcium ion transmembrane transport", "Mitochondrial cytochrome c oxidase assembly", "Mitochondrial depolarization", "Mitochondrial dna metabolic process", "Mitochondrial dna repair", "Mitochondrial dna replication", "Mitochondrial electron transport cytochrome c to oxygen", "Mitochondrial electron transport nadh to ubiquinone", "Mitochondrial electron transport ubiquinol to cytochrome c", "Mitochondrial fission", "Mitochondrial fragmentation involved in apoptotic process", "Mitochondrial fusion", "Mitochondrial gene expression", "Mitochondrial genome maintenance", "Mitochondrial membrane organization", "Mitochondrial outer membrane permeabilization", "Mitochondrial outer membrane permeabilization involved in programmed cell death", "Mitochondrial protein catabolic process", "Mitochondrial protein processing", "Mitochondrial proton transporting atp synthase complex assembly", "Mitochondrial respirasome assembly", "Mitochondrial respiratory chain complex assembly", "Mitochondrial ribosome assembly", "Mitochondrial rna 3 end processing", "Mitochondrial rna catabolic process", "Mitochondrial rna metabolic process", "Mitochondrial rna modification", "Mitochondrial rna processing", "Mitochondrial transcription", "Mitochondrial translation", "Mitochondrial translational elongation", "Mitochondrial transmembrane transport", "Mitochondrial transport", "Mitochondrial trna processing", "Mitochondrion distribution", "Mitochondrion endoplasmic reticulum membrane tethering", "Mitochondrion localization", "Mitochondrion morphogenesis", "Mitochondrion organization", "Mitophagy", "Mitotic cell cycle", "Mitotic cell cycle checkpoint signaling", "Mitotic cell cycle phase transition", "Mitotic cell cycle process", "Mitotic chromosome condensation", "Mitotic cytokinesis", "Mitotic cytokinetic process", "Mitotic dna integrity checkpoint signaling", "Mitotic dna replication", "Mitotic dna replication checkpoint signaling", "Mitotic g1 s transition checkpoint signaling", "Mitotic g2 dna damage checkpoint signaling", "Mitotic g2 m transition checkpoint", "Mitotic intra s dna damage checkpoint signaling", "Mitotic metaphase plate congression", "Mitotic nuclear division", "Mitotic nuclear membrane disassembly", "Mitotic nuclear membrane organization", "Mitotic recombination", "Mitotic sister chromatid cohesion", "Mitotic sister chromatid segregation", "Mitotic spindle assembly", "Mitotic spindle midzone assembly", "Mitotic spindle organization", "Modification dependent macromolecule catabolic process", "Modification of postsynaptic actin cytoskeleton", "Modification of postsynaptic structure", "Modification of synaptic structure", "Modified amino acid transport", "Modulation by host of symbiont catalytic activity", "Modulation by host of symbiont process", "Modulation by host of viral genome replication", "Modulation by host of viral process", "Modulation of age related behavioral decline", "Modulation of excitatory postsynaptic potential", "Molting cycle", "Monoacylglycerol catabolic process", "Monoacylglycerol metabolic process", "Monoamine transport", "Monocarboxylic acid biosynthetic process", "Monocarboxylic acid catabolic process", "Monocarboxylic acid metabolic process", "Monocarboxylic acid transport", "Monocyte chemotaxis", "Monocyte differentiation", "Mononuclear cell differentiation", "Mononuclear cell migration", "Monosaccharide biosynthetic process", "Monosaccharide catabolic process", "Monosaccharide metabolic process", "Monoubiquitinated protein deubiquitination", "Monovalent inorganic anion homeostasis", "Monovalent inorganic cation homeostasis", "Morphogenesis of a branching structure", "Morphogenesis of a polarized epithelium", "Morphogenesis of an endothelium", "Morphogenesis of an epithelial bud", "Morphogenesis of an epithelial fold", "Morphogenesis of an epithelial sheet", "Morphogenesis of an epithelium", "Morphogenesis of embryonic epithelium", "Motor behavior", "Motor learning", "Motor neuron apoptotic process", "Motor neuron axon guidance", "Motor neuron migration", "Mrna 3 end processing", "Mrna 3 end processing by stem loop binding and cleavage", "Mrna 3 splice site recognition", "Mrna 5 splice site recognition", "Mrna alternative polyadenylation", "Mrna catabolic process", "Mrna cis splicing via spliceosome", "Mrna cleavage", "Mrna cleavage involved in mrna processing", "Mrna destabilization mediated gene silencing", "Mrna export from nucleus", "Mrna metabolic process", "Mrna methylation", "Mrna modification", "Mrna processing", "Mrna pseudouridine synthesis", "Mrna splice site selection", "Mrna transcription", "Mrna transport", "Mucopolysaccharide metabolic process", "Multi multicellular organism process", "Multi organism reproductive process", "Multicellular organism aging", "Multicellular organism growth", "Multicellular organism reproduction", "Multicellular organismal homeostasis", "Multicellular organismal movement", "Multicellular organismal response to stress", "Multicellular organismal signaling", "Multivesicular body organization", "Multivesicular body sorting pathway", "Muscle adaptation", "Muscle cell apoptotic process", "Muscle cell cellular homeostasis", "Muscle cell development", "Muscle cell differentiation", "Muscle cell migration", "Muscle cell proliferation", "Muscle contraction", "Muscle hypertrophy", "Muscle hypertrophy in response to stress", "Muscle organ development", "Muscle organ morphogenesis", "Muscle structure development", "Muscle system process", "Muscle tissue development", "Myd88 dependent toll like receptor signaling pathway", "Myelin assembly", "Myelin maintenance", "Myeloid cell activation involved in immune response", "Myeloid cell apoptotic process", "Myeloid cell development", "Myeloid cell differentiation", "Myeloid cell homeostasis", "Myeloid dendritic cell activation", "Myeloid dendritic cell cytokine production", "Myeloid leukocyte activation", "Myeloid leukocyte cytokine production", "Myeloid leukocyte differentiation", "Myeloid leukocyte mediated immunity", "Myeloid leukocyte migration", "Myoblast differentiation", "Myoblast fusion", "Myoblast migration", "Myofibroblast differentiation", "Myotube cell development", "Myotube differentiation", "N acetylglucosamine metabolic process", "N acetylneuraminate catabolic process", "N acetylneuraminate metabolic process", "N acylethanolamine metabolic process", "N glycan processing", "N terminal peptidyl methionine acetylation", "N terminal protein amino acid acetylation", "N terminal protein amino acid modification", "N terminal protein lipidation", "Nad biosynthesis via nicotinamide riboside salvage pathway", "Nad metabolic process", "Nadh dehydrogenase complex assembly", "Nadh metabolic process", "Nadh oxidation", "Nadh regeneration", "Nadp metabolic process", "Nadph regeneration", "Natural killer cell activation", "Natural killer cell activation involved in immune response", "Natural killer cell degranulation", "Natural killer cell differentiation", "Natural killer cell mediated immunity", "Ncrna 3 end processing", "Ncrna catabolic process", "Ncrna export from nucleus", "Ncrna metabolic process", "Ncrna processing", "Ncrna transcription", "Necroptotic signaling pathway", "Necrotic cell death", "Negative chemotaxis", "Negative regulation by host of viral genome replication", "Negative regulation by host of viral process", "Negative regulation by host of viral transcription", "Negative regulation of actin filament bundle assembly", "Negative regulation of actin filament depolymerization", "Negative regulation of actin filament polymerization", "Negative regulation of actin nucleation", "Negative regulation of activated t cell proliferation", "Negative regulation of activin receptor signaling pathway", "Negative regulation of adaptive immune response", "Negative regulation of adenylate cyclase activating adrenergic receptor signaling pathway", "Negative regulation of adenylate cyclase activating g protein coupled receptor signaling pathway", "Negative regulation of adenylate cyclase activity", "Negative regulation of alcohol biosynthetic process", "Negative regulation of alpha beta t cell activation", "Negative regulation of alpha beta t cell differentiation", "Negative regulation of amine transport", "Negative regulation of amino acid transport", "Negative regulation of amyloid beta clearance", "Negative regulation of amyloid fibril formation", "Negative regulation of amyloid precursor protein biosynthetic process", "Negative regulation of amyloid precursor protein catabolic process", "Negative regulation of androgen receptor signaling pathway", "Negative regulation of anion transmembrane transport", "Negative regulation of anion transport", "Negative regulation of anoikis", "Negative regulation of antigen receptor mediated signaling pathway", "Negative regulation of apoptotic signaling pathway", "Negative regulation of arp2 3 complex mediated actin nucleation", "Negative regulation of atp biosynthetic process", "Negative regulation of atp dependent activity", "Negative regulation of atp metabolic process", "Negative regulation of atpase coupled calcium transmembrane transporter activity", "Negative regulation of autophagosome assembly", "Negative regulation of autophagy", "Negative regulation of autophagy of mitochondrion", "Negative regulation of axon extension", "Negative regulation of axon extension involved in axon guidance", "Negative regulation of axonogenesis", "Negative regulation of b cell activation", "Negative regulation of b cell apoptotic process", "Negative regulation of b cell differentiation", "Negative regulation of b cell mediated immunity", "Negative regulation of bicellular tight junction assembly", "Negative regulation of binding", "Negative regulation of biomineralization", "Negative regulation of biosynthetic process", "Negative regulation of blood circulation", "Negative regulation of blood pressure", "Negative regulation of blood vessel endothelial cell migration", "Negative regulation of bmp signaling pathway", "Negative regulation of bone remodeling", "Negative regulation of calcineurin mediated signaling", "Negative regulation of calcium ion dependent exocytosis", "Negative regulation of calcium ion import", "Negative regulation of calcium ion transmembrane transport", "Negative regulation of calcium ion transport", "Negative regulation of calcium ion transport into cytosol", "Negative regulation of calcium mediated signaling", "Negative regulation of camp dependent protein kinase activity", "Negative regulation of camp mediated signaling", "Negative regulation of canonical wnt signaling pathway", "Negative regulation of carbohydrate metabolic process", "Negative regulation of cardiac muscle adaptation", "Negative regulation of cardiac muscle contraction", "Negative regulation of cardiac muscle tissue growth", "Negative regulation of cartilage development", "Negative regulation of catabolic process", "Negative regulation of catalytic activity", "Negative regulation of cation channel activity", "Negative regulation of cd4 positive alpha beta t cell activation", "Negative regulation of cd4 positive alpha beta t cell differentiation", "Negative regulation of cell activation", "Negative regulation of cell adhesion", "Negative regulation of cell adhesion mediated by integrin", "Negative regulation of cell aging", "Negative regulation of cell cell adhesion", "Negative regulation of cell cycle", "Negative regulation of cell cycle checkpoint", "Negative regulation of cell cycle g1 s phase transition", "Negative regulation of cell cycle g2 m phase transition", "Negative regulation of cell cycle phase transition", "Negative regulation of cell cycle process", "Negative regulation of cell death", "Negative regulation of cell development", "Negative regulation of cell differentiation", "Negative regulation of cell division", "Negative regulation of cell growth", "Negative regulation of cell growth involved in cardiac muscle cell development", "Negative regulation of cell junction assembly", "Negative regulation of cell killing", "Negative regulation of cell matrix adhesion", "Negative regulation of cell morphogenesis involved in differentiation", "Negative regulation of cell population proliferation", "Negative regulation of cell projection organization", "Negative regulation of cell size", "Negative regulation of cell substrate adhesion", "Negative regulation of cell substrate junction organization", "Negative regulation of cell volume", "Negative regulation of cellular amide metabolic process", "Negative regulation of cellular catabolic process", "Negative regulation of cellular component organization", "Negative regulation of cellular macromolecule biosynthetic process", "Negative regulation of cellular protein catabolic process", "Negative regulation of cellular respiration", "Negative regulation of cellular response to growth factor stimulus", "Negative regulation of cellular response to hypoxia", "Negative regulation of cellular response to insulin stimulus", "Negative regulation of cellular senescence", "Negative regulation of centriole replication", "Negative regulation of centrosome duplication", "Negative regulation of chemokine mediated signaling pathway", "Negative regulation of chemotaxis", "Negative regulation of cholesterol metabolic process", "Negative regulation of chondrocyte differentiation", "Negative regulation of chromatin binding", "Negative regulation of chromatin organization", "Negative regulation of chromosome organization", "Negative regulation of cilium assembly", "Negative regulation of circadian rhythm", "Negative regulation of coagulation", "Negative regulation of cold induced thermogenesis", "Negative regulation of collateral sprouting", "Negative regulation of cyclic nucleotide phosphodiesterase activity", "Negative regulation of cyclin dependent protein serine threonine kinase activity", "Negative regulation of cysteine type endopeptidase activity", "Negative regulation of cysteine type endopeptidase activity involved in apoptotic signaling pathway", "Negative regulation of cytokine production", "Negative regulation of cytokine production involved in immune response", "Negative regulation of cytokine production involved in inflammatory response", "Negative regulation of cytokinesis", "Negative regulation of cytoplasmic translation", "Negative regulation of cytoskeleton organization", "Negative regulation of defense response", "Negative regulation of defense response to virus", "Negative regulation of dendrite development", "Negative regulation of dendrite morphogenesis", "Negative regulation of dendritic spine development", "Negative regulation of dephosphorylation", "Negative regulation of developmental growth", "Negative regulation of developmental process", "Negative regulation of dna binding", "Negative regulation of dna binding transcription factor activity", "Negative regulation of dna biosynthetic process", "Negative regulation of dna damage checkpoint", "Negative regulation of dna damage response signal transduction by p53 class mediator", "Negative regulation of dna dependent dna replication", "Negative regulation of dna metabolic process", "Negative regulation of dna recombination", "Negative regulation of dna repair", "Negative regulation of dna replication", "Negative regulation of dna templated transcription elongation", "Negative regulation of dna templated transcription initiation", "Negative regulation of double strand break repair via homologous recombination", "Negative regulation of endocytosis", "Negative regulation of endoplasmic reticulum calcium ion concentration", "Negative regulation of endoplasmic reticulum stress induced eif2 alpha phosphorylation", "Negative regulation of endoplasmic reticulum stress induced intrinsic apoptotic signaling pathway", "Negative regulation of endoplasmic reticulum unfolded protein response", "Negative regulation of endothelial cell proliferation", "Negative regulation of epidermal growth factor activated receptor activity", "Negative regulation of epidermis development", "Negative regulation of epithelial cell apoptotic process", "Negative regulation of epithelial cell differentiation", "Negative regulation of epithelial cell migration", "Negative regulation of epithelial cell proliferation", "Negative regulation of erad pathway", "Negative regulation of erbb signaling pathway", "Negative regulation of erk1 and erk2 cascade", "Negative regulation of erythrocyte differentiation", "Negative regulation of establishment of protein localization", "Negative regulation of establishment of protein localization to mitochondrion", "Negative regulation of excitatory postsynaptic potential", "Negative regulation of execution phase of apoptosis", "Negative regulation of exocytosis", "Negative regulation of extrinsic apoptotic signaling pathway", "Negative regulation of extrinsic apoptotic signaling pathway via death domain receptors", "Negative regulation of fat cell differentiation", "Negative regulation of fatty acid beta oxidation", "Negative regulation of fatty acid biosynthetic process", "Negative regulation of fatty acid metabolic process", "Negative regulation of fatty acid oxidation", "Negative regulation of fatty acid transport", "Negative regulation of fibroblast apoptotic process", "Negative regulation of fibroblast migration", "Negative regulation of fibroblast proliferation", "Negative regulation of filopodium assembly", "Negative regulation of g protein coupled receptor signaling pathway", "Negative regulation of gene expression", "Negative regulation of gene expression epigenetic", "Negative regulation of glial cell apoptotic process", "Negative regulation of glial cell differentiation", "Negative regulation of glial cell proliferation", "Negative regulation of gliogenesis", "Negative regulation of glucocorticoid metabolic process", "Negative regulation of gluconeogenesis", "Negative regulation of glucose import", "Negative regulation of glucose transmembrane transport", "Negative regulation of glycogen metabolic process", "Negative regulation of glycolytic process", "Negative regulation of glycoprotein metabolic process", "Negative regulation of golgi to plasma membrane protein transport", "Negative regulation of granulocyte chemotaxis", "Negative regulation of growth", "Negative regulation of gtpase activity", "Negative regulation of guanyl nucleotide exchange factor activity", "Negative regulation of heart rate", "Negative regulation of helicase activity", "Negative regulation of hematopoietic progenitor cell differentiation", "Negative regulation of hemopoiesis", "Negative regulation of hepatocyte apoptotic process", "Negative regulation of high voltage gated calcium channel activity", "Negative regulation of histone acetylation", "Negative regulation of histone h3 k27 methylation", "Negative regulation of histone h3 k4 methylation", "Negative regulation of histone h3 k9 methylation", "Negative regulation of histone h3 k9 trimethylation", "Negative regulation of histone h4 acetylation", "Negative regulation of histone methylation", "Negative regulation of histone modification", "Negative regulation of histone phosphorylation", "Negative regulation of homotypic cell cell adhesion", "Negative regulation of hormone biosynthetic process", "Negative regulation of hormone metabolic process", "Negative regulation of hormone secretion", "Negative regulation of hydrogen peroxide mediated programmed cell death", "Negative regulation of hydrolase activity", "Negative regulation of hypoxia induced intrinsic apoptotic signaling pathway", "Negative regulation of i kappab kinase nf kappab signaling", "Negative regulation of immune effector process", "Negative regulation of immune response", "Negative regulation of immune system process", "Negative regulation of immunoglobulin production", "Negative regulation of inclusion body assembly", "Negative regulation of inflammatory response", "Negative regulation of inflammatory response to antigenic stimulus", "Negative regulation of innate immune response", "Negative regulation of interferon gamma production", "Negative regulation of interleukin 12 production", "Negative regulation of interleukin 2 production", "Negative regulation of interleukin 6 production", "Negative regulation of interleukin 8 production", "Negative regulation of intracellular estrogen receptor signaling pathway", "Negative regulation of intracellular protein transport", "Negative regulation of intracellular signal transduction", "Negative regulation of intracellular steroid hormone receptor signaling pathway", "Negative regulation of intracellular transport", "Negative regulation of intrinsic apoptotic signaling pathway", "Negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator", "Negative regulation of intrinsic apoptotic signaling pathway in response to dna damage", "Negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress", "Negative regulation of ion transmembrane transport", "Negative regulation of ion transmembrane transporter activity", "Negative regulation of ion transport", "Negative regulation of ire1 mediated unfolded protein response", "Negative regulation of isotype switching", "Negative regulation of jnk cascade", "Negative regulation of jun kinase activity", "Negative regulation of keratinocyte differentiation", "Negative regulation of keratinocyte proliferation", "Negative regulation of kidney development", "Negative regulation of kinase activity", "Negative regulation of lamellipodium assembly", "Negative regulation of lamellipodium organization", "Negative regulation of leukocyte apoptotic process", "Negative regulation of leukocyte cell cell adhesion", "Negative regulation of leukocyte chemotaxis", "Negative regulation of leukocyte degranulation", "Negative regulation of leukocyte mediated immunity", "Negative regulation of leukocyte migration", "Negative regulation of leukocyte proliferation", "Negative regulation of lipase activity", "Negative regulation of lipid biosynthetic process", "Negative regulation of lipid catabolic process", "Negative regulation of lipid kinase activity", "Negative regulation of lipid localization", "Negative regulation of lipid metabolic process", "Negative regulation of lipid storage", "Negative regulation of lipid transport", "Negative regulation of lipopolysaccharide mediated signaling pathway", "Negative regulation of lipoprotein lipase activity", "Negative regulation of lipoprotein particle clearance", "Negative regulation of locomotion", "Negative regulation of long term synaptic potentiation", "Negative regulation of low density lipoprotein particle clearance", "Negative regulation of low density lipoprotein receptor activity", "Negative regulation of lyase activity", "Negative regulation of lymphocyte activation", "Negative regulation of lymphocyte apoptotic process", "Negative regulation of lymphocyte differentiation", "Negative regulation of lymphocyte mediated immunity", "Negative regulation of macroautophagy", "Negative regulation of macrophage chemotaxis", "Negative regulation of macrophage migration", "Negative regulation of map kinase activity", "Negative regulation of mapk cascade", "Negative regulation of mast cell activation", "Negative regulation of mast cell activation involved in immune response", "Negative regulation of mast cell degranulation", "Negative regulation of megakaryocyte differentiation", "Negative regulation of meiotic cell cycle", "Negative regulation of meiotic nuclear division", "Negative regulation of membrane permeability", "Negative regulation of membrane potential", "Negative regulation of membrane protein ectodomain proteolysis", "Negative regulation of mesenchymal cell proliferation", "Negative regulation of metalloendopeptidase activity", "Negative regulation of metallopeptidase activity", "Negative regulation of metaphase anaphase transition of cell cycle", "Negative regulation of mhc class ii biosynthetic process", "Negative regulation of microtubule polymerization", "Negative regulation of microtubule polymerization or depolymerization", "Negative regulation of mirna transcription", "Negative regulation of mitochondrial fusion", "Negative regulation of mitochondrial membrane permeability", "Negative regulation of mitochondrial membrane permeability involved in apoptotic process", "Negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway", "Negative regulation of mitochondrion organization", "Negative regulation of mitophagy", "Negative regulation of mitotic cell cycle", "Negative regulation of mitotic cell cycle phase transition", "Negative regulation of molecular function", "Negative regulation of monocyte chemotaxis", "Negative regulation of monocyte differentiation", "Negative regulation of mononuclear cell migration", "Negative regulation of monooxygenase activity", "Negative regulation of mrna 3 end processing", "Negative regulation of mrna catabolic process", "Negative regulation of mrna metabolic process", "Negative regulation of mrna processing", "Negative regulation of mrna splicing via spliceosome", "Negative regulation of multicellular organism growth", "Negative regulation of multicellular organismal process", "Negative regulation of muscle adaptation", "Negative regulation of muscle cell apoptotic process", "Negative regulation of muscle cell differentiation", "Negative regulation of muscle contraction", "Negative regulation of muscle hypertrophy", "Negative regulation of myelination", "Negative regulation of myeloid cell apoptotic process", "Negative regulation of myeloid cell differentiation", "Negative regulation of myeloid leukocyte differentiation", "Negative regulation of myeloid leukocyte mediated immunity", "Negative regulation of myosin light chain phosphatase activity", "Negative regulation of natural killer cell mediated immunity", "Negative regulation of necrotic cell death", "Negative regulation of nervous system development", "Negative regulation of nervous system process", "Negative regulation of neural precursor cell proliferation", "Negative regulation of neuroblast proliferation", "Negative regulation of neuron apoptotic process", "Negative regulation of neuron death", "Negative regulation of neuron differentiation", "Negative regulation of neuron migration", "Negative regulation of neuron projection development", "Negative regulation of neuron projection regeneration", "Negative regulation of neurotransmitter secretion", "Negative regulation of neurotransmitter transport", "Negative regulation of neutrophil migration", "Negative regulation of nf kappab transcription factor activity", "Negative regulation of nik nf kappab signaling", "Negative regulation of nitric oxide metabolic process", "Negative regulation of nitric oxide synthase activity", "Negative regulation of notch signaling pathway", "Negative regulation of nuclear division", "Negative regulation of nuclear transcribed mrna catabolic process deadenylation dependent decay", "Negative regulation of nuclear transcribed mrna catabolic process nonsense mediated decay", "Negative regulation of nuclease activity", "Negative regulation of nucleobase containing compound metabolic process", "Negative regulation of nucleocytoplasmic transport", "Negative regulation of nucleotide biosynthetic process", "Negative regulation of nucleotide metabolic process", "Negative regulation of oligodendrocyte differentiation", "Negative regulation of organ growth", "Negative regulation of organelle assembly", "Negative regulation of organelle organization", "Negative regulation of organic acid transport", "Negative regulation of osteoblast differentiation", "Negative regulation of osteoblast proliferation", "Negative regulation of osteoclast differentiation", "Negative regulation of oxidative phosphorylation", "Negative regulation of oxidative stress induced cell death", "Negative regulation of oxidative stress induced intrinsic apoptotic signaling pathway", "Negative regulation of oxidative stress induced neuron death", "Negative regulation of oxidative stress induced neuron intrinsic apoptotic signaling pathway", "Negative regulation of oxidoreductase activity", "Negative regulation of p38mapk cascade", "Negative regulation of peptidase activity", "Negative regulation of peptide secretion", "Negative regulation of peptidyl lysine acetylation", "Negative regulation of peptidyl serine phosphorylation", "Negative regulation of peptidyl threonine phosphorylation", "Negative regulation of peptidyl tyrosine phosphorylation", "Negative regulation of perk mediated unfolded protein response", "Negative regulation of phagocytosis", "Negative regulation of phosphatase activity", "Negative regulation of phosphatidylinositol 3 kinase signaling", "Negative regulation of phospholipase activity", "Negative regulation of phospholipid metabolic process", "Negative regulation of phosphoprotein phosphatase activity", "Negative regulation of phosphorus metabolic process", "Negative regulation of phosphorylation", "Negative regulation of plasma membrane bounded cell projection assembly", "Negative regulation of platelet activation", "Negative regulation of platelet derived growth factor receptor signaling pathway", "Negative regulation of posttranscriptional gene silencing", "Negative regulation of potassium ion transmembrane transport", "Negative regulation of potassium ion transport", "Negative regulation of production of mirnas involved in gene silencing by mirna", "Negative regulation of production of molecular mediator of immune response", "Negative regulation of programmed necrotic cell death", "Negative regulation of proteasomal protein catabolic process", "Negative regulation of proteasomal ubiquitin dependent protein catabolic process", "Negative regulation of protein acetylation", "Negative regulation of protein autophosphorylation", "Negative regulation of protein binding", "Negative regulation of protein catabolic process", "Negative regulation of protein containing complex assembly", "Negative regulation of protein containing complex disassembly", "Negative regulation of protein dephosphorylation", "Negative regulation of protein export from nucleus", "Negative regulation of protein import into nucleus", "Negative regulation of protein k63 linked ubiquitination", "Negative regulation of protein kinase activity by regulation of protein phosphorylation", "Negative regulation of protein kinase b signaling", "Negative regulation of protein localization", "Negative regulation of protein localization to cell periphery", "Negative regulation of protein localization to cell surface", "Negative regulation of protein localization to membrane", "Negative regulation of protein localization to nucleus", "Negative regulation of protein maturation", "Negative regulation of protein metabolic process", "Negative regulation of protein modification by small protein conjugation or removal", "Negative regulation of protein modification process", "Negative regulation of protein polymerization", "Negative regulation of protein polyubiquitination", "Negative regulation of protein secretion", "Negative regulation of protein serine threonine kinase activity", "Negative regulation of protein sumoylation", "Negative regulation of protein targeting to membrane", "Negative regulation of protein targeting to mitochondrion", "Negative regulation of protein tyrosine kinase activity", "Negative regulation of proteolysis", "Negative regulation of proteolysis involved in cellular protein catabolic process", "Negative regulation of reactive oxygen species biosynthetic process", "Negative regulation of reactive oxygen species metabolic process", "Negative regulation of receptor binding", "Negative regulation of receptor internalization", "Negative regulation of receptor mediated endocytosis", "Negative regulation of receptor signaling pathway via jak stat", "Negative regulation of receptor signaling pathway via stat", "Negative regulation of regulated secretory pathway", "Negative regulation of release of cytochrome c from mitochondria", "Negative regulation of reproductive process", "Negative regulation of respiratory burst", "Negative regulation of respiratory burst involved in inflammatory response", "Negative regulation of response to biotic stimulus", "Negative regulation of response to cytokine stimulus", "Negative regulation of response to dna damage stimulus", "Negative regulation of response to endoplasmic reticulum stress", "Negative regulation of response to external stimulus", "Negative regulation of response to food", "Negative regulation of response to oxidative stress", "Negative regulation of response to reactive oxygen species", "Negative regulation of response to stimulus", "Negative regulation of response to wounding", "Negative regulation of retinoic acid receptor signaling pathway", "Negative regulation of rho protein signal transduction", "Negative regulation of rig i signaling pathway", "Negative regulation of rna catabolic process", "Negative regulation of rna polymerase ii regulatory region sequence specific dna binding", "Negative regulation of rna splicing", "Negative regulation of ruffle assembly", "Negative regulation of ryanodine sensitive calcium release channel activity", "Negative regulation of schwann cell proliferation", "Negative regulation of secondary metabolite biosynthetic process", "Negative regulation of secretion", "Negative regulation of sequestering of triglyceride", "Negative regulation of signal transduction by p53 class mediator", "Negative regulation of signal transduction in absence of ligand", "Negative regulation of signaling", "Negative regulation of signaling receptor activity", "Negative regulation of single stranded viral rna replication via double stranded dna intermediate", "Negative regulation of sister chromatid cohesion", "Negative regulation of small gtpase mediated signal transduction", "Negative regulation of small molecule metabolic process", "Negative regulation of smooth muscle cell apoptotic process", "Negative regulation of smooth muscle cell differentiation", "Negative regulation of smooth muscle cell migration", "Negative regulation of smooth muscle cell proliferation", "Negative regulation of smoothened signaling pathway", "Negative regulation of sodium ion transmembrane transport", "Negative regulation of sodium ion transport", "Negative regulation of stem cell differentiation", "Negative regulation of steroid metabolic process", "Negative regulation of stress activated protein kinase signaling cascade", "Negative regulation of striated muscle cell apoptotic process", "Negative regulation of striated muscle cell differentiation", "Negative regulation of striated muscle contraction", "Negative regulation of supramolecular fiber organization", "Negative regulation of synapse assembly", "Negative regulation of synapse organization", "Negative regulation of synaptic transmission", "Negative regulation of synaptic transmission glutamatergic", "Negative regulation of synaptic vesicle exocytosis", "Negative regulation of systemic arterial blood pressure", "Negative regulation of t cell apoptotic process", "Negative regulation of t cell differentiation", "Negative regulation of t cell proliferation", "Negative regulation of t cell receptor signaling pathway", "Negative regulation of t helper cell differentiation", "Negative regulation of telomerase activity", "Negative regulation of telomere capping", "Negative regulation of telomere maintenance", "Negative regulation of telomere maintenance via telomerase", "Negative regulation of telomere maintenance via telomere lengthening", "Negative regulation of tissue remodeling", "Negative regulation of toll like receptor signaling pathway", "Negative regulation of tor signaling", "Negative regulation of transcription by competitive promoter binding", "Negative regulation of transcription by rna polymerase i", "Negative regulation of transcription by rna polymerase ii", "Negative regulation of transcription from rna polymerase ii promoter in response to stress", "Negative regulation of transcription initiation from rna polymerase ii promoter", "Negative regulation of transcription regulatory region dna binding", "Negative regulation of transferase activity", "Negative regulation of transforming growth factor beta production", "Negative regulation of transforming growth factor beta receptor signaling pathway", "Negative regulation of transforming growth factor beta1 production", "Negative regulation of translational elongation", "Negative regulation of translational initiation", "Negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway", "Negative regulation of transmembrane transport", "Negative regulation of transport", "Negative regulation of transporter activity", "Negative regulation of trophoblast cell migration", "Negative regulation of tumor necrosis factor superfamily cytokine production", "Negative regulation of type 2 immune response", "Negative regulation of type b pancreatic cell apoptotic process", "Negative regulation of type i interferon mediated signaling pathway", "Negative regulation of type i interferon production", "Negative regulation of tyrosine phosphorylation of stat protein", "Negative regulation of ubiquitin dependent protein catabolic process", "Negative regulation of ubiquitin protein ligase activity", "Negative regulation of ubiquitin protein transferase activity", "Negative regulation of vascular associated smooth muscle cell apoptotic process", "Negative regulation of vascular associated smooth muscle cell differentiation", "Negative regulation of vascular associated smooth muscle cell migration", "Negative regulation of vascular associated smooth muscle cell proliferation", "Negative regulation of vascular endothelial growth factor production", "Negative regulation of vascular endothelial growth factor receptor signaling pathway", "Negative regulation of vascular permeability", "Negative regulation of vascular wound healing", "Negative regulation of vasculature development", "Negative regulation of viral entry into host cell", "Negative regulation of viral genome replication", "Negative regulation of viral induced cytoplasmic pattern recognition receptor signaling pathway", "Negative regulation of viral life cycle", "Negative regulation of viral process", "Negative regulation of viral transcription", "Negative regulation of vitamin metabolic process", "Negative regulation of voltage gated calcium channel activity", "Negative regulation of wnt signaling pathway", "Negative regulation of wound healing", "Nephric duct development", "Nephric duct morphogenesis", "Nephron development", "Nephron epithelium development", "Nephron morphogenesis", "Nephron tubule epithelial cell differentiation", "Nephron tubule formation", "Nerve development", "Nerve growth factor signaling pathway", "Nervous system process", "Nervous system process involved in regulation of systemic arterial blood pressure", "Neural crest cell differentiation", "Neural crest cell migration", "Neural crest cell migration involved in autonomic nervous system development", "Neural crest formation", "Neural nucleus development", "Neural plate development", "Neural plate morphogenesis", "Neural precursor cell proliferation", "Neural retina development", "Neural tube development", "Neural tube formation", "Neural tube patterning", "Neuroblast division", "Neuroblast proliferation", "Neuroendocrine cell differentiation", "Neuroepithelial cell differentiation", "Neurofilament cytoskeleton organization", "Neurogenesis", "Neuroinflammatory response", "Neuromuscular junction development", "Neuromuscular process", "Neuromuscular process controlling balance", "Neuromuscular process controlling posture", "Neuron apoptotic process", "Neuron cellular homeostasis", "Neuron death", "Neuron death in response to hydrogen peroxide", "Neuron death in response to oxidative stress", "Neuron development", "Neuron differentiation", "Neuron fate commitment", "Neuron fate determination", "Neuron intrinsic apoptotic signaling pathway in response to oxidative stress", "Neuron maturation", "Neuron migration", "Neuron projection arborization", "Neuron projection extension", "Neuron projection extension involved in neuron projection guidance", "Neuron projection guidance", "Neuron projection maintenance", "Neuron projection organization", "Neuron projection regeneration", "Neuron recognition", "Neuron remodeling", "Neuronal action potential", "Neuronal ion channel clustering", "Neuronal stem cell population maintenance", "Neuropeptide signaling pathway", "Neurotransmitter biosynthetic process", "Neurotransmitter catabolic process", "Neurotransmitter gated ion channel clustering", "Neurotransmitter metabolic process", "Neurotransmitter receptor internalization", "Neurotransmitter receptor localization to postsynaptic specialization membrane", "Neurotransmitter receptor transport", "Neurotransmitter receptor transport endosome to postsynaptic membrane", "Neurotransmitter receptor transport postsynaptic endosome to lysosome", "Neurotransmitter receptor transport to plasma membrane", "Neurotransmitter reuptake", "Neurotransmitter secretion", "Neurotransmitter transport", "Neurotransmitter uptake", "Neurotrophin production", "Neurotrophin signaling pathway", "Neurotrophin trk receptor signaling pathway", "Neutral amino acid transport", "Neutral lipid biosynthetic process", "Neutral lipid catabolic process", "Neutral lipid metabolic process", "Neutrophil activation involved in immune response", "Neutrophil apoptotic process", "Neutrophil chemotaxis", "Neutrophil clearance", "Neutrophil degranulation", "Neutrophil differentiation", "Neutrophil homeostasis", "Neutrophil mediated immunity", "Neutrophil migration", "Nik nf kappab signaling", "Nitric oxide synthase biosynthetic process", "Nitrogen compound transport", "Nk t cell activation", "Nk t cell differentiation", "Nls bearing protein import into nucleus", "Non canonical wnt signaling pathway", "Non lytic viral release", "Non membrane bounded organelle assembly", "Non motile cilium assembly", "Nonribosomal peptide biosynthetic process", "Nose development", "Notch receptor processing", "Notch signaling pathway", "Nuclear body organization", "Nuclear chromosome segregation", "Nuclear envelope organization", "Nuclear export", "Nuclear membrane organization", "Nuclear membrane reassembly", "Nuclear migration", "Nuclear ncrna surveillance", "Nuclear pore complex assembly", "Nuclear pore organization", "Nuclear transcribed mrna catabolic process", "Nuclear transcribed mrna catabolic process deadenylation dependent decay", "Nuclear transcribed mrna catabolic process deadenylation independent decay", "Nuclear transcribed mrna catabolic process exonucleolytic", "Nuclear transcribed mrna catabolic process exonucleolytic 3 5", "Nuclear transcribed mrna catabolic process nonsense mediated decay", "Nuclear transcribed mrna poly a tail shortening", "Nuclear transport", "Nucleic acid phosphodiester bond hydrolysis", "Nucleobase biosynthetic process", "Nucleobase catabolic process", "Nucleobase containing compound transport", "Nucleobase containing small molecule biosynthetic process", "Nucleobase containing small molecule catabolic process", "Nucleobase containing small molecule interconversion", "Nucleobase containing small molecule metabolic process", "Nucleobase metabolic process", "Nucleobase transport", "Nucleolar chromatin organization", "Nucleolar large rrna transcription by rna polymerase i", "Nucleolus organization", "Nucleoside bisphosphate biosynthetic process", "Nucleoside bisphosphate catabolic process", "Nucleoside bisphosphate metabolic process", "Nucleoside catabolic process", "Nucleoside diphosphate biosynthetic process", "Nucleoside diphosphate catabolic process", "Nucleoside diphosphate metabolic process", "Nucleoside metabolic process", "Nucleoside monophosphate biosynthetic process", "Nucleoside monophosphate catabolic process", "Nucleoside monophosphate metabolic process", "Nucleoside monophosphate phosphorylation", "Nucleoside phosphate biosynthetic process", "Nucleoside phosphate catabolic process", "Nucleoside salvage", "Nucleoside transmembrane transport", "Nucleoside transport", "Nucleoside triphosphate biosynthetic process", "Nucleoside triphosphate catabolic process", "Nucleoside triphosphate metabolic process", "Nucleosome assembly", "Nucleosome mobilization", "Nucleosome organization", "Nucleosome positioning", "Nucleotide binding domain leucine rich repeat containing receptor signaling pathway", "Nucleotide binding oligomerization domain containing 2 signaling pathway", "Nucleotide excision repair", "Nucleotide excision repair dna gap filling", "Nucleotide excision repair dna incision", "Nucleotide phosphorylation", "Nucleotide salvage", "Nucleotide sugar biosynthetic process", "Nucleotide sugar metabolic process", "Nucleotide sugar transmembrane transport", "Nucleotide transmembrane transport", "Nucleotide transport", "Nucleus localization", "Nucleus organization", "O glycan processing", "Odontoblast differentiation", "Odontogenesis", "Odontogenesis of dentin containing tooth", "Olefinic compound biosynthetic process", "Olefinic compound metabolic process", "Olfactory behavior", "Olfactory bulb interneuron development", "Olfactory bulb interneuron differentiation", "Olfactory lobe development", "Oligodendrocyte development", "Oligodendrocyte differentiation", "Oligopeptide transport", "Oligosaccharide catabolic process", "Oligosaccharide lipid intermediate biosynthetic process", "Oligosaccharide metabolic process", "One carbon metabolic process", "Oocyte construction", "Oocyte differentiation", "Oocyte maturation", "Oogenesis", "Optic nerve development", "Organ growth", "Organ induction", "Organ or tissue specific immune response", "Organelle assembly", "Organelle disassembly", "Organelle fission", "Organelle fusion", "Organelle inheritance", "Organelle localization", "Organelle membrane fusion", "Organelle transport along microtubule", "Organic acid biosynthetic process", "Organic acid catabolic process", "Organic acid metabolic process", "Organic acid transmembrane transport", "Organic acid transport", "Organic anion transport", "Organic cation transport", "Organic cyclic compound catabolic process", "Organic hydroxy compound biosynthetic process", "Organic hydroxy compound catabolic process", "Organic hydroxy compound metabolic process", "Organic hydroxy compound transport", "Organism emergence from protective structure", "Organonitrogen compound biosynthetic process", "Organonitrogen compound catabolic process", "Organophosphate biosynthetic process", "Organophosphate catabolic process", "Organophosphate ester transport", "Organophosphate metabolic process", "Ornithine metabolic process", "Ornithine transport", "Ossification", "Osteoblast differentiation", "Osteoblast proliferation", "Osteoclast development", "Osteoclast differentiation", "Outer dynein arm assembly", "Outer ear morphogenesis", "Outer mitochondrial membrane organization", "Outflow tract morphogenesis", "Outflow tract septum morphogenesis", "Ovarian follicle development", "Oviduct development", "Ovulation cycle", "Ovulation cycle process", "Oxaloacetate metabolic process", "Oxaloacetate transport", "Oxidative demethylation", "Oxidative dna demethylation", "Oxidative phosphorylation", "Oxidative rna demethylation", "Oxygen homeostasis", "P body assembly", "P38mapk cascade", "Pallium development", "Pancreas development", "Pancreatic juice secretion", "Pantothenate metabolic process", "Parallel actin filament bundle assembly", "Paranodal junction assembly", "Parasympathetic nervous system development", "Parathyroid gland development", "Paraxial mesoderm development", "Parkin mediated stimulation of mitophagy in response to mitochondrial depolarization", "Pathway restricted smad protein phosphorylation", "Pattern recognition receptor signaling pathway", "Pattern specification involved in kidney development", "Pattern specification process", "Penetration of zona pellucida", "Pentose catabolic process", "Pentose metabolic process", "Pentose phosphate shunt", "Pentose phosphate shunt non oxidative branch", "Peptide antigen assembly with mhc protein complex", "Peptide biosynthetic process", "Peptide catabolic process", "Peptide cross linking", "Peptide metabolic process", "Peptide transport", "Peptidyl amino acid modification", "Peptidyl arginine methylation", "Peptidyl arginine methylation to asymmetrical dimethyl arginine", "Peptidyl arginine modification", "Peptidyl arginine n methylation", "Peptidyl asparagine modification", "Peptidyl cysteine modification", "Peptidyl diphthamide biosynthetic process from peptidyl histidine", "Peptidyl glutamic acid modification", "Peptidyl glutamine methylation", "Peptidyl histidine modification", "Peptidyl lysine acetylation", "Peptidyl lysine dimethylation", "Peptidyl lysine hydroxylation", "Peptidyl lysine methylation", "Peptidyl lysine modification", "Peptidyl lysine trimethylation", "Peptidyl methionine modification", "Peptidyl proline hydroxylation", "Peptidyl proline hydroxylation to 4 hydroxy l proline", "Peptidyl proline modification", "Peptidyl serine dephosphorylation", "Peptidyl serine modification", "Peptidyl threonine dephosphorylation", "Peptidyl threonine modification", "Peptidyl tyrosine dephosphorylation", "Peptidyl tyrosine dephosphorylation involved in inactivation of protein kinase activity", "Peptidyl tyrosine modification", "Pericyte cell differentiation", "Peripheral nervous system axon regeneration", "Peripheral nervous system development", "Peripheral nervous system myelin maintenance", "Perk mediated unfolded protein response", "Peroxisomal transport", "Peroxisome fission", "Peroxisome organization", "Peroxisome proliferator activated receptor signaling pathway", "Ph reduction", "Phagocytosis", "Phagocytosis recognition", "Phagolysosome assembly", "Phagosome acidification", "Phagosome lysosome fusion", "Phagosome maturation", "Pharyngeal system development", "Phenol containing compound biosynthetic process", "Phenol containing compound catabolic process", "Phenol containing compound metabolic process", "Phenotypic switching", "Phosphagen metabolic process", "Phosphate ion transmembrane transport", "Phosphate ion transport", "Phosphatidic acid metabolic process", "Phosphatidylcholine acyl chain remodeling", "Phosphatidylcholine biosynthetic process", "Phosphatidylcholine catabolic process", "Phosphatidylcholine metabolic process", "Phosphatidylethanolamine acyl chain remodeling", "Phosphatidylethanolamine biosynthetic process", "Phosphatidylethanolamine metabolic process", "Phosphatidylglycerol acyl chain remodeling", "Phosphatidylglycerol biosynthetic process", "Phosphatidylglycerol metabolic process", "Phosphatidylinositol 3 kinase signaling", "Phosphatidylinositol 3 phosphate biosynthetic process", "Phosphatidylinositol acyl chain remodeling", "Phosphatidylinositol biosynthetic process", "Phosphatidylinositol dephosphorylation", "Phosphatidylinositol metabolic process", "Phosphatidylinositol phosphate biosynthetic process", "Phosphatidylserine acyl chain remodeling", "Phosphatidylserine metabolic process", "Phospholipase c activating dopamine receptor signaling pathway", "Phospholipase c activating g protein coupled receptor signaling pathway", "Phospholipid biosynthetic process", "Phospholipid catabolic process", "Phospholipid dephosphorylation", "Phospholipid homeostasis", "Phospholipid metabolic process", "Phospholipid transport", "Phosphorylation", "Phosphorylation of rna polymerase ii c terminal domain", "Photoperiodism", "Photoreceptor cell development", "Photoreceptor cell differentiation", "Photoreceptor cell maintenance", "Photoreceptor cell outer segment organization", "Phototransduction", "Phototransduction visible light", "Physiological cardiac muscle hypertrophy", "Pigment accumulation", "Pigment biosynthetic process", "Pigment cell differentiation", "Pigment granule localization", "Pigment granule maturation", "Pigment granule organization", "Pigment metabolic process", "Pigmentation", "Pinocytosis", "Pirna metabolic process", "Placenta blood vessel development", "Placenta development", "Planar cell polarity pathway involved in neural tube closure", "Plasma lipoprotein particle clearance", "Plasma membrane fusion", "Plasma membrane organization", "Plasma membrane phospholipid scrambling", "Plasma membrane raft assembly", "Plasma membrane raft organization", "Plasma membrane repair", "Plasma membrane to endosome transport", "Plasma membrane tubulation", "Plasminogen activation", "Platelet activating factor metabolic process", "Platelet activation", "Platelet aggregation", "Platelet derived growth factor receptor alpha signaling pathway", "Platelet derived growth factor receptor beta signaling pathway", "Platelet derived growth factor receptor signaling pathway", "Platelet morphogenesis", "Plus end directed organelle transport along microtubule", "Pml body organization", "Podosome assembly", "Pointed end actin filament capping", "Polarized epithelial cell differentiation", "Poly a plus mrna export from nucleus", "Poly n acetyllactosamine metabolic process", "Polyadenylation dependent rna catabolic process", "Polyadenylation dependent snorna 3 end processing", "Polyamine biosynthetic process", "Polyamine metabolic process", "Polyketide metabolic process", "Polyol biosynthetic process", "Polyol catabolic process", "Polyol metabolic process", "Polyprenol metabolic process", "Polysaccharide biosynthetic process", "Polysaccharide catabolic process", "Polysaccharide metabolic process", "Pons development", "Pore complex assembly", "Porphyrin containing compound metabolic process", "Positive chemotaxis", "Positive regulation by host of viral genome replication", "Positive regulation by host of viral process", "Positive regulation by host of viral transcription", "Positive regulation by symbiont of entry into host", "Positive regulation of 3 utr mediated mrna stabilization", "Positive regulation of actin cytoskeleton reorganization", "Positive regulation of actin filament bundle assembly", "Positive regulation of actin filament depolymerization", "Positive regulation of actin filament polymerization", "Positive regulation of actin nucleation", "Positive regulation of action potential", "Positive regulation of activated t cell proliferation", "Positive regulation of activin receptor signaling pathway", "Positive regulation of acute inflammatory response", "Positive regulation of acute inflammatory response to antigenic stimulus", "Positive regulation of adaptive immune response", "Positive regulation of alcohol biosynthetic process", "Positive regulation of alpha beta t cell activation", "Positive regulation of alpha beta t cell differentiation", "Positive regulation of alpha beta t cell proliferation", "Positive regulation of amine transport", "Positive regulation of amino acid transport", "Positive regulation of amyloid beta clearance", "Positive regulation of amyloid beta formation", "Positive regulation of amyloid precursor protein biosynthetic process", "Positive regulation of amyloid precursor protein catabolic process", "Positive regulation of animal organ morphogenesis", "Positive regulation of anion transmembrane transport", "Positive regulation of anion transport", "Positive regulation of anoikis", "Positive regulation of antigen receptor mediated signaling pathway", "Positive regulation of apoptotic signaling pathway", "Positive regulation of arp2 3 complex mediated actin nucleation", "Positive regulation of aspartic type peptidase activity", "Positive regulation of astrocyte differentiation", "Positive regulation of atp biosynthetic process", "Positive regulation of atp dependent activity", "Positive regulation of atp metabolic process", "Positive regulation of atpase coupled calcium transmembrane transporter activity", "Positive regulation of attachment of spindle microtubules to kinetochore", "Positive regulation of autophagy", "Positive regulation of autophagy of mitochondrion", "Positive regulation of axon extension", "Positive regulation of axon extension involved in axon guidance", "Positive regulation of axonogenesis", "Positive regulation of b cell activation", "Positive regulation of b cell mediated immunity", "Positive regulation of b cell proliferation", "Positive regulation of basement membrane assembly involved in embryonic body morphogenesis", "Positive regulation of behavior", "Positive regulation of binding", "Positive regulation of biomineralization", "Positive regulation of blood brain barrier permeability", "Positive regulation of blood circulation", "Positive regulation of blood pressure", "Positive regulation of blood pressure by epinephrine norepinephrine", "Positive regulation of blood vessel endothelial cell migration", "Positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis", "Positive regulation of bmp signaling pathway", "Positive regulation of bone mineralization", "Positive regulation of bone resorption", "Positive regulation of brown fat cell differentiation", "Positive regulation of calcineurin mediated signaling", "Positive regulation of calcium ion dependent exocytosis", "Positive regulation of calcium ion import", "Positive regulation of calcium ion transmembrane transport", "Positive regulation of calcium ion transmembrane transporter activity", "Positive regulation of calcium ion transport", "Positive regulation of calcium ion transport into cytosol", "Positive regulation of calcium mediated signaling", "Positive regulation of camp dependent protein kinase activity", "Positive regulation of camp mediated signaling", "Positive regulation of canonical wnt signaling pathway", "Positive regulation of carbohydrate metabolic process", "Positive regulation of cardiac muscle cell proliferation", "Positive regulation of cardioblast differentiation", "Positive regulation of cardiocyte differentiation", "Positive regulation of cartilage development", "Positive regulation of catabolic process", "Positive regulation of catalytic activity", "Positive regulation of catecholamine metabolic process", "Positive regulation of cation channel activity", "Positive regulation of cd4 positive alpha beta t cell activation", "Positive regulation of cd4 positive alpha beta t cell differentiation", "Positive regulation of cd8 positive alpha beta t cell activation", "Positive regulation of cell activation", "Positive regulation of cell adhesion", "Positive regulation of cell adhesion mediated by integrin", "Positive regulation of cell adhesion molecule production", "Positive regulation of cell aging", "Positive regulation of cell cell adhesion", "Positive regulation of cell cell adhesion mediated by cadherin", "Positive regulation of cell cell adhesion mediated by integrin", "Positive regulation of cell cycle", "Positive regulation of cell cycle checkpoint", "Positive regulation of cell cycle g1 s phase transition", "Positive regulation of cell cycle g2 m phase transition", "Positive regulation of cell cycle phase transition", "Positive regulation of cell cycle process", "Positive regulation of cell death", "Positive regulation of cell development", "Positive regulation of cell differentiation", "Positive regulation of cell division", "Positive regulation of cell growth", "Positive regulation of cell junction assembly", "Positive regulation of cell killing", "Positive regulation of cell matrix adhesion", "Positive regulation of cell maturation", "Positive regulation of cell migration by vascular endothelial growth factor signaling pathway", "Positive regulation of cell migration involved in sprouting angiogenesis", "Positive regulation of cell morphogenesis involved in differentiation", "Positive regulation of cell population proliferation", "Positive regulation of cell projection organization", "Positive regulation of cell size", "Positive regulation of cell substrate adhesion", "Positive regulation of cell substrate junction organization", "Positive regulation of cellular amide metabolic process", "Positive regulation of cellular amine metabolic process", "Positive regulation of cellular biosynthetic process", "Positive regulation of cellular carbohydrate metabolic process", "Positive regulation of cellular component biogenesis", "Positive regulation of cellular component organization", "Positive regulation of cellular protein catabolic process", "Positive regulation of cellular respiration", "Positive regulation of cellular response to insulin stimulus", "Positive regulation of cellular response to transforming growth factor beta stimulus", "Positive regulation of centriole elongation", "Positive regulation of centriole replication", "Positive regulation of chemokine c c motif ligand 5 production", "Positive regulation of chemokine c x c motif ligand 2 production", "Positive regulation of chemokine production", "Positive regulation of chemotaxis", "Positive regulation of cholesterol biosynthetic process", "Positive regulation of cholesterol metabolic process", "Positive regulation of cholesterol storage", "Positive regulation of chondrocyte differentiation", "Positive regulation of chromatin binding", "Positive regulation of chromatin organization", "Positive regulation of chromosome condensation", "Positive regulation of chromosome organization", "Positive regulation of chromosome segregation", "Positive regulation of chromosome separation", "Positive regulation of cilium assembly", "Positive regulation of circadian rhythm", "Positive regulation of clathrin dependent endocytosis", "Positive regulation of coagulation", "Positive regulation of cold induced thermogenesis", "Positive regulation of collagen metabolic process", "Positive regulation of collateral sprouting", "Positive regulation of complement activation", "Positive regulation of connective tissue replacement", "Positive regulation of cyclic nucleotide phosphodiesterase activity", "Positive regulation of cyclin dependent protein kinase activity", "Positive regulation of cysteine type endopeptidase activity", "Positive regulation of cysteine type endopeptidase activity involved in apoptotic signaling pathway", "Positive regulation of cytokine production", "Positive regulation of cytokine production involved in immune response", "Positive regulation of cytokine production involved in inflammatory response", "Positive regulation of cytokinesis", "Positive regulation of cytoplasmic translation", "Positive regulation of cytoplasmic transport", "Positive regulation of cytoskeleton organization", "Positive regulation of defense response", "Positive regulation of defense response to virus by host", "Positive regulation of dendrite development", "Positive regulation of dendrite morphogenesis", "Positive regulation of dendritic cell cytokine production", "Positive regulation of dendritic cell differentiation", "Positive regulation of dendritic spine development", "Positive regulation of dendritic spine morphogenesis", "Positive regulation of deoxyribonuclease activity", "Positive regulation of dephosphorylation", "Positive regulation of developmental growth", "Positive regulation of developmental process", "Positive regulation of digestive system process", "Positive regulation of dna binding", "Positive regulation of dna binding transcription factor activity", "Positive regulation of dna biosynthetic process", "Positive regulation of dna damage response signal transduction by p53 class mediator", "Positive regulation of dna demethylation", "Positive regulation of dna dependent dna replication", "Positive regulation of dna ligation", "Positive regulation of dna metabolic process", "Positive regulation of dna methylation dependent heterochromatin assembly", "Positive regulation of dna recombination", "Positive regulation of dna repair", "Positive regulation of dna replication", "Positive regulation of dna templated transcription elongation", "Positive regulation of dna templated transcription initiation", "Positive regulation of dopamine receptor signaling pathway", "Positive regulation of double strand break repair", "Positive regulation of double strand break repair via homologous recombination", "Positive regulation of double strand break repair via nonhomologous end joining", "Positive regulation of early endosome to late endosome transport", "Positive regulation of embryonic development", "Positive regulation of endocytic recycling", "Positive regulation of endocytosis", "Positive regulation of endoplasmic reticulum unfolded protein response", "Positive regulation of endothelial cell apoptotic process", "Positive regulation of endothelial cell chemotaxis", "Positive regulation of endothelial cell chemotaxis by vegf activated vascular endothelial growth factor receptor signaling pathway", "Positive regulation of endothelial cell development", "Positive regulation of endothelial cell differentiation", "Positive regulation of endothelial cell migration", "Positive regulation of endothelial cell proliferation", "Positive regulation of epidermal cell differentiation", "Positive regulation of epidermis development", "Positive regulation of epithelial cell apoptotic process", "Positive regulation of epithelial cell differentiation", "Positive regulation of epithelial cell migration", "Positive regulation of epithelial cell proliferation", "Positive regulation of epithelial cell proliferation involved in lung morphogenesis", "Positive regulation of epithelial to mesenchymal transition", "Positive regulation of er associated ubiquitin dependent protein catabolic process", "Positive regulation of erad pathway", "Positive regulation of erbb signaling pathway", "Positive regulation of erk1 and erk2 cascade", "Positive regulation of erythrocyte differentiation", "Positive regulation of establishment of protein localization", "Positive regulation of establishment of protein localization to mitochondrion", "Positive regulation of establishment of protein localization to telomere", "Positive regulation of excitatory postsynaptic potential", "Positive regulation of execution phase of apoptosis", "Positive regulation of exocytosis", "Positive regulation of exosomal secretion", "Positive regulation of extracellular matrix assembly", "Positive regulation of extracellular matrix disassembly", "Positive regulation of extracellular matrix organization", "Positive regulation of extrinsic apoptotic signaling pathway", "Positive regulation of extrinsic apoptotic signaling pathway in absence of ligand", "Positive regulation of extrinsic apoptotic signaling pathway via death domain receptors", "Positive regulation of fat cell differentiation", "Positive regulation of fatty acid beta oxidation", "Positive regulation of fatty acid biosynthetic process", "Positive regulation of fatty acid metabolic process", "Positive regulation of fatty acid oxidation", "Positive regulation of fatty acid transport", "Positive regulation of fc receptor mediated stimulatory signaling pathway", "Positive regulation of feeding behavior", "Positive regulation of fibroblast growth factor receptor signaling pathway", "Positive regulation of fibroblast migration", "Positive regulation of fibroblast proliferation", "Positive regulation of filopodium assembly", "Positive regulation of focal adhesion assembly", "Positive regulation of g protein coupled receptor signaling pathway", "Positive regulation of g0 to g1 transition", "Positive regulation of g1 s transition of mitotic cell cycle", "Positive regulation of gastrulation", "Positive regulation of gene expression", "Positive regulation of glial cell differentiation", "Positive regulation of glial cell migration", "Positive regulation of glial cell proliferation", "Positive regulation of gliogenesis", "Positive regulation of glucokinase activity", "Positive regulation of gluconeogenesis", "Positive regulation of glucose import", "Positive regulation of glucose metabolic process", "Positive regulation of glucose transmembrane transport", "Positive regulation of glycogen metabolic process", "Positive regulation of glycolytic process", "Positive regulation of glycoprotein metabolic process", "Positive regulation of golgi to plasma membrane protein transport", "Positive regulation of gonad development", "Positive regulation of granulocyte chemotaxis", "Positive regulation of growth", "Positive regulation of gtpase activity", "Positive regulation of hair follicle development", "Positive regulation of heart growth", "Positive regulation of heart rate", "Positive regulation of helicase activity", "Positive regulation of hematopoietic progenitor cell differentiation", "Positive regulation of hemopoiesis", "Positive regulation of hepatocyte proliferation", "Positive regulation of heterotypic cell cell adhesion", "Positive regulation of hexokinase activity", "Positive regulation of hippo signaling", "Positive regulation of histone acetylation", "Positive regulation of histone deacetylation", "Positive regulation of histone h3 k27 methylation", "Positive regulation of histone h3 k4 methylation", "Positive regulation of histone h3 k9 acetylation", "Positive regulation of histone h3 k9 methylation", "Positive regulation of histone h4 acetylation", "Positive regulation of histone methylation", "Positive regulation of histone modification", "Positive regulation of histone phosphorylation", "Positive regulation of histone ubiquitination", "Positive regulation of hormone biosynthetic process", "Positive regulation of hormone metabolic process", "Positive regulation of hormone secretion", "Positive regulation of humoral immune response", "Positive regulation of hydrogen peroxide metabolic process", "Positive regulation of hydrolase activity", "Positive regulation of i kappab kinase nf kappab signaling", "Positive regulation of i kappab phosphorylation", "Positive regulation of immune effector process", "Positive regulation of immune response", "Positive regulation of immune system process", "Positive regulation of immunoglobulin production", "Positive regulation of inclusion body assembly", "Positive regulation of inflammatory response", "Positive regulation of inflammatory response to antigenic stimulus", "Positive regulation of innate immune response", "Positive regulation of insulin like growth factor receptor signaling pathway", "Positive regulation of insulin secretion", "Positive regulation of insulin secretion involved in cellular response to glucose stimulus", "Positive regulation of integrin mediated signaling pathway", "Positive regulation of interferon alpha production", "Positive regulation of interferon beta production", "Positive regulation of interferon gamma production", "Positive regulation of interleukin 1 alpha production", "Positive regulation of interleukin 1 beta production", "Positive regulation of interleukin 1 production", "Positive regulation of interleukin 10 production", "Positive regulation of interleukin 12 production", "Positive regulation of interleukin 17 production", "Positive regulation of interleukin 18 production", "Positive regulation of interleukin 2 production", "Positive regulation of interleukin 6 production", "Positive regulation of interleukin 8 production", "Positive regulation of intracellular lipid transport", "Positive regulation of intracellular protein transport", "Positive regulation of intracellular signal transduction", "Positive regulation of intracellular steroid hormone receptor signaling pathway", "Positive regulation of intracellular transport", "Positive regulation of intrinsic apoptotic signaling pathway", "Positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator", "Positive regulation of intrinsic apoptotic signaling pathway in response to dna damage", "Positive regulation of ion transmembrane transport", "Positive regulation of ion transport", "Positive regulation of ire1 mediated unfolded protein response", "Positive regulation of isotype switching", "Positive regulation of isotype switching to iga isotypes", "Positive regulation of isotype switching to igg isotypes", "Positive regulation of jnk cascade", "Positive regulation of jun kinase activity", "Positive regulation of keratinocyte differentiation", "Positive regulation of keratinocyte proliferation", "Positive regulation of kinase activity", "Positive regulation of lamellipodium assembly", "Positive regulation of lamellipodium morphogenesis", "Positive regulation of lamellipodium organization", "Positive regulation of leukocyte adhesion to vascular endothelial cell", "Positive regulation of leukocyte apoptotic process", "Positive regulation of leukocyte cell cell adhesion", "Positive regulation of leukocyte chemotaxis", "Positive regulation of leukocyte degranulation", "Positive regulation of leukocyte mediated immunity", "Positive regulation of leukocyte migration", "Positive regulation of leukocyte proliferation", "Positive regulation of ligase activity", "Positive regulation of lipase activity", "Positive regulation of lipid biosynthetic process", "Positive regulation of lipid catabolic process", "Positive regulation of lipid kinase activity", "Positive regulation of lipid localization", "Positive regulation of lipid metabolic process", "Positive regulation of lipid storage", "Positive regulation of lipid transport", "Positive regulation of lipopolysaccharide mediated signaling pathway", "Positive regulation of lipoprotein particle clearance", "Positive regulation of locomotion", "Positive regulation of long term synaptic depression", "Positive regulation of long term synaptic potentiation", "Positive regulation of low density lipoprotein receptor activity", "Positive regulation of lyase activity", "Positive regulation of lymphocyte apoptotic process", "Positive regulation of lymphocyte chemotaxis", "Positive regulation of lymphocyte differentiation", "Positive regulation of lymphocyte mediated immunity", "Positive regulation of lymphocyte migration", "Positive regulation of macroautophagy", "Positive regulation of macrophage activation", "Positive regulation of macrophage chemotaxis", "Positive regulation of macrophage differentiation", "Positive regulation of macrophage migration", "Positive regulation of maintenance of sister chromatid cohesion", "Positive regulation of mammary gland epithelial cell proliferation", "Positive regulation of map kinase activity", "Positive regulation of mapk cascade", "Positive regulation of mast cell activation", "Positive regulation of mast cell activation involved in immune response", "Positive regulation of megakaryocyte differentiation", "Positive regulation of meiotic cell cycle", "Positive regulation of meiotic cell cycle phase transition", "Positive regulation of membrane depolarization", "Positive regulation of membrane permeability", "Positive regulation of membrane potential", "Positive regulation of membrane protein ectodomain proteolysis", "Positive regulation of mesenchymal cell proliferation", "Positive regulation of metalloendopeptidase activity", "Positive regulation of metallopeptidase activity", "Positive regulation of metaphase anaphase transition of cell cycle", "Positive regulation of mhc class i biosynthetic process", "Positive regulation of microglial cell activation", "Positive regulation of microtubule binding", "Positive regulation of microtubule nucleation", "Positive regulation of microtubule polymerization or depolymerization", "Positive regulation of mirna catabolic process", "Positive regulation of mirna mediated gene silencing by inhibition of translation", "Positive regulation of mirna metabolic process", "Positive regulation of mirna transcription", "Positive regulation of mitochondrial calcium ion concentration", "Positive regulation of mitochondrial depolarization", "Positive regulation of mitochondrial fission", "Positive regulation of mitochondrial membrane potential", "Positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway", "Positive regulation of mitochondrial translation", "Positive regulation of mitochondrion organization", "Positive regulation of mitophagy", "Positive regulation of mitophagy in response to mitochondrial depolarization", "Positive regulation of mitotic cell cycle", "Positive regulation of mitotic cell cycle phase transition", "Positive regulation of mitotic cell cycle spindle assembly checkpoint", "Positive regulation of mitotic nuclear division", "Positive regulation of molecular function", "Positive regulation of monocyte chemotaxis", "Positive regulation of monocyte differentiation", "Positive regulation of mononuclear cell migration", "Positive regulation of monooxygenase activity", "Positive regulation of morphogenesis of an epithelium", "Positive regulation of mrna 3 end processing", "Positive regulation of mrna metabolic process", "Positive regulation of mrna processing", "Positive regulation of mrna splicing via spliceosome", "Positive regulation of multicellular organism growth", "Positive regulation of multicellular organismal process", "Positive regulation of muscle cell apoptotic process", "Positive regulation of muscle cell differentiation", "Positive regulation of muscle contraction", "Positive regulation of muscle hypertrophy", "Positive regulation of muscle tissue development", "Positive regulation of myelination", "Positive regulation of myeloid cell apoptotic process", "Positive regulation of myeloid cell differentiation", "Positive regulation of myeloid leukocyte cytokine production involved in immune response", "Positive regulation of myeloid leukocyte differentiation", "Positive regulation of myeloid leukocyte mediated immunity", "Positive regulation of myoblast differentiation", "Positive regulation of myoblast fusion", "Positive regulation of myotube differentiation", "Positive regulation of nad p h oxidase activity", "Positive regulation of natural killer cell activation", "Positive regulation of natural killer cell mediated cytotoxicity", "Positive regulation of natural killer cell mediated immunity", "Positive regulation of necrotic cell death", "Positive regulation of nervous system development", "Positive regulation of nervous system process", "Positive regulation of neural precursor cell proliferation", "Positive regulation of neuroblast proliferation", "Positive regulation of neurogenesis", "Positive regulation of neuroinflammatory response", "Positive regulation of neuron apoptotic process", "Positive regulation of neuron death", "Positive regulation of neuron differentiation", "Positive regulation of neuron migration", "Positive regulation of neuron projection arborization", "Positive regulation of neuron projection development", "Positive regulation of neuron projection regeneration", "Positive regulation of neurotransmitter secretion", "Positive regulation of neurotransmitter transport", "Positive regulation of neurotransmitter uptake", "Positive regulation of neurotrophin trk receptor signaling pathway", "Positive regulation of neutrophil migration", "Positive regulation of nf kappab transcription factor activity", "Positive regulation of nik nf kappab signaling", "Positive regulation of nitric oxide metabolic process", "Positive regulation of nitric oxide synthase activity", "Positive regulation of nitric oxide synthase biosynthetic process", "Positive regulation of nk t cell activation", "Positive regulation of nlrp3 inflammasome complex assembly", "Positive regulation of non motile cilium assembly", "Positive regulation of notch signaling pathway", "Positive regulation of nuclear cell cycle dna replication", "Positive regulation of nuclear division", "Positive regulation of nuclear transcribed mrna catabolic process deadenylation dependent decay", "Positive regulation of nuclease activity", "Positive regulation of nucleobase containing compound metabolic process", "Positive regulation of nucleobase containing compound transport", "Positive regulation of nucleocytoplasmic transport", "Positive regulation of nucleotide binding oligomerization domain containing 2 signaling pathway", "Positive regulation of nucleotide binding oligomerization domain containing signaling pathway", "Positive regulation of nucleotide biosynthetic process", "Positive regulation of nucleotide metabolic process", "Positive regulation of oligodendrocyte differentiation", "Positive regulation of organ growth", "Positive regulation of organelle assembly", "Positive regulation of organelle organization", "Positive regulation of organic acid transport", "Positive regulation of ossification", "Positive regulation of osteoblast differentiation", "Positive regulation of oxidative stress induced cell death", "Positive regulation of oxidative stress induced intrinsic apoptotic signaling pathway", "Positive regulation of oxidative stress induced neuron death", "Positive regulation of oxidoreductase activity", "Positive regulation of p38mapk cascade", "Positive regulation of pathway restricted smad protein phosphorylation", "Positive regulation of pattern recognition receptor signaling pathway", "Positive regulation of peptidase activity", "Positive regulation of peptide secretion", "Positive regulation of peptidyl lysine acetylation", "Positive regulation of peptidyl serine phosphorylation", "Positive regulation of peptidyl threonine phosphorylation", "Positive regulation of peptidyl tyrosine phosphorylation", "Positive regulation of phagocytosis", "Positive regulation of phosphatase activity", "Positive regulation of phosphatidylinositol 3 kinase signaling", "Positive regulation of phospholipase a2 activity", "Positive regulation of phospholipase activity", "Positive regulation of phospholipid biosynthetic process", "Positive regulation of phospholipid metabolic process", "Positive regulation of phosphoprotein phosphatase activity", "Positive regulation of phosphorus metabolic process", "Positive regulation of pinocytosis", "Positive regulation of plasma membrane bounded cell projection assembly", "Positive regulation of plasminogen activation", "Positive regulation of podosome assembly", "Positive regulation of posttranscriptional gene silencing", "Positive regulation of potassium ion import across plasma membrane", "Positive regulation of potassium ion transmembrane transporter activity", "Positive regulation of potassium ion transport", "Positive regulation of production of mirnas involved in gene silencing by mirna", "Positive regulation of production of molecular mediator of immune response", "Positive regulation of programmed necrotic cell death", "Positive regulation of prostaglandin biosynthetic process", "Positive regulation of proteasomal ubiquitin dependent protein catabolic process", "Positive regulation of protein acetylation", "Positive regulation of protein autophosphorylation", "Positive regulation of protein binding", "Positive regulation of protein catabolic process", "Positive regulation of protein containing complex assembly", "Positive regulation of protein containing complex disassembly", "Positive regulation of protein deacetylation", "Positive regulation of protein dephosphorylation", "Positive regulation of protein depolymerization", "Positive regulation of protein deubiquitination", "Positive regulation of protein exit from endoplasmic reticulum", "Positive regulation of protein export from nucleus", "Positive regulation of protein glycosylation", "Positive regulation of protein import", "Positive regulation of protein k63 linked ubiquitination", "Positive regulation of protein kinase a signaling", "Positive regulation of protein kinase activity", "Positive regulation of protein kinase b signaling", "Positive regulation of protein localization", "Positive regulation of protein localization to cell cortex", "Positive regulation of protein localization to cell periphery", "Positive regulation of protein localization to cell surface", "Positive regulation of protein localization to centrosome", "Positive regulation of protein localization to cilium", "Positive regulation of protein localization to early endosome", "Positive regulation of protein localization to membrane", "Positive regulation of protein localization to nucleus", "Positive regulation of protein maturation", "Positive regulation of protein metabolic process", "Positive regulation of protein modification by small protein conjugation or removal", "Positive regulation of protein modification process", "Positive regulation of protein monoubiquitination", "Positive regulation of protein neddylation", "Positive regulation of protein phosphorylation", "Positive regulation of protein polymerization", "Positive regulation of protein polyubiquitination", "Positive regulation of protein secretion", "Positive regulation of protein serine threonine kinase activity", "Positive regulation of protein sumoylation", "Positive regulation of protein targeting to membrane", "Positive regulation of protein tyrosine kinase activity", "Positive regulation of proteolysis", "Positive regulation of proteolysis involved in cellular protein catabolic process", "Positive regulation of pseudopodium assembly", "Positive regulation of reactive oxygen species biosynthetic process", "Positive regulation of reactive oxygen species metabolic process", "Positive regulation of receptor binding", "Positive regulation of receptor catabolic process", "Positive regulation of receptor clustering", "Positive regulation of receptor internalization", "Positive regulation of receptor mediated endocytosis", "Positive regulation of receptor recycling", "Positive regulation of receptor signaling pathway via stat", "Positive regulation of regulated secretory pathway", "Positive regulation of release of cytochrome c from mitochondria", "Positive regulation of release of sequestered calcium ion into cytosol", "Positive regulation of renal sodium excretion", "Positive regulation of reproductive process", "Positive regulation of respiratory burst", "Positive regulation of response to biotic stimulus", "Positive regulation of response to cytokine stimulus", "Positive regulation of response to dna damage stimulus", "Positive regulation of response to endoplasmic reticulum stress", "Positive regulation of response to external stimulus", "Positive regulation of response to interferon gamma", "Positive regulation of response to tumor cell", "Positive regulation of response to wounding", "Positive regulation of retinoic acid receptor signaling pathway", "Positive regulation of rho protein signal transduction", "Positive regulation of rig i signaling pathway", "Positive regulation of rna binding", "Positive regulation of rna export from nucleus", "Positive regulation of rna metabolic process", "Positive regulation of rna polymerase ii transcription preinitiation complex assembly", "Positive regulation of rna splicing", "Positive regulation of rrna processing", "Positive regulation of ruffle assembly", "Positive regulation of ryanodine sensitive calcium release channel activity", "Positive regulation of secretion", "Positive regulation of sequestering of calcium ion", "Positive regulation of sequestering of triglyceride", "Positive regulation of signal transduction by p53 class mediator", "Positive regulation of signaling", "Positive regulation of signaling receptor activity", "Positive regulation of sister chromatid cohesion", "Positive regulation of skeletal muscle fiber development", "Positive regulation of skeletal muscle tissue development", "Positive regulation of smad protein signal transduction", "Positive regulation of small gtpase mediated signal transduction", "Positive regulation of small molecule metabolic process", "Positive regulation of smooth muscle cell apoptotic process", "Positive regulation of smooth muscle cell differentiation", "Positive regulation of smooth muscle cell migration", "Positive regulation of smooth muscle cell proliferation", "Positive regulation of smooth muscle contraction", "Positive regulation of smoothened signaling pathway", "Positive regulation of sodium ion transmembrane transport", "Positive regulation of sodium ion transmembrane transporter activity", "Positive regulation of sodium ion transport", "Positive regulation of sphingolipid biosynthetic process", "Positive regulation of spindle assembly", "Positive regulation of sprouting angiogenesis", "Positive regulation of stem cell differentiation", "Positive regulation of stem cell proliferation", "Positive regulation of steroid biosynthetic process", "Positive regulation of steroid hormone biosynthetic process", "Positive regulation of steroid metabolic process", "Positive regulation of sterol transport", "Positive regulation of stress activated protein kinase signaling cascade", "Positive regulation of stress fiber assembly", "Positive regulation of striated muscle cell apoptotic process", "Positive regulation of striated muscle cell differentiation", "Positive regulation of striated muscle contraction", "Positive regulation of substrate adhesion dependent cell spreading", "Positive regulation of supramolecular fiber organization", "Positive regulation of synapse assembly", "Positive regulation of synapse maturation", "Positive regulation of synaptic plasticity", "Positive regulation of synaptic transmission", "Positive regulation of synaptic transmission gabaergic", "Positive regulation of synaptic vesicle endocytosis", "Positive regulation of synaptic vesicle exocytosis", "Positive regulation of synaptic vesicle recycling", "Positive regulation of syncytium formation by plasma membrane fusion", "Positive regulation of t cell apoptotic process", "Positive regulation of t cell cytokine production", "Positive regulation of t cell mediated cytotoxicity", "Positive regulation of t cell mediated immune response to tumor cell", "Positive regulation of t cell mediated immunity", "Positive regulation of t cell migration", "Positive regulation of t cell proliferation", "Positive regulation of t cell receptor signaling pathway", "Positive regulation of t helper 1 cell differentiation", "Positive regulation of t helper cell differentiation", "Positive regulation of tau protein kinase activity", "Positive regulation of telomerase activity", "Positive regulation of telomerase rna localization to cajal body", "Positive regulation of telomere capping", "Positive regulation of telomere maintenance", "Positive regulation of telomere maintenance via telomere lengthening", "Positive regulation of tissue remodeling", "Positive regulation of toll like receptor 3 signaling pathway", "Positive regulation of toll like receptor 9 signaling pathway", "Positive regulation of toll like receptor signaling pathway", "Positive regulation of tor signaling", "Positive regulation of torc1 signaling", "Positive regulation of transcription by rna polymerase i", "Positive regulation of transcription by rna polymerase ii", "Positive regulation of transcription by rna polymerase iii", "Positive regulation of transcription elongation from rna polymerase ii promoter", "Positive regulation of transcription from rna polymerase ii promoter in response to endoplasmic reticulum stress", "Positive regulation of transcription from rna polymerase ii promoter in response to hypoxia", "Positive regulation of transcription from rna polymerase ii promoter in response to stress", "Positive regulation of transcription from rna polymerase ii promoter involved in cellular response to chemical stimulus", "Positive regulation of transcription of nucleolar large rrna by rna polymerase i", "Positive regulation of transcription regulatory region dna binding", "Positive regulation of transferase activity", "Positive regulation of transforming growth factor beta production", "Positive regulation of transforming growth factor beta1 production", "Positive regulation of translation", "Positive regulation of translation in response to endoplasmic reticulum stress", "Positive regulation of translation in response to stress", "Positive regulation of translational initiation", "Positive regulation of transmembrane receptor protein serine threonine kinase signaling pathway", "Positive regulation of transmembrane transport", "Positive regulation of transmission of nerve impulse", "Positive regulation of transport", "Positive regulation of transporter activity", "Positive regulation of triglyceride biosynthetic process", "Positive regulation of triglyceride metabolic process", "Positive regulation of trophoblast cell migration", "Positive regulation of tumor necrosis factor mediated signaling pathway", "Positive regulation of tumor necrosis factor superfamily cytokine production", "Positive regulation of type i interferon mediated signaling pathway", "Positive regulation of type i interferon production", "Positive regulation of tyrosine phosphorylation of stat protein", "Positive regulation of ubiquitin dependent protein catabolic process", "Positive regulation of ubiquitin protein ligase activity", "Positive regulation of ubiquitin protein transferase activity", "Positive regulation of unsaturated fatty acid biosynthetic process", "Positive regulation of urine volume", "Positive regulation of vacuole organization", "Positive regulation of vascular associated smooth muscle cell apoptotic process", "Positive regulation of vascular associated smooth muscle cell differentiation", "Positive regulation of vascular associated smooth muscle cell migration", "Positive regulation of vascular associated smooth muscle cell proliferation", "Positive regulation of vascular endothelial cell proliferation", "Positive regulation of vascular endothelial growth factor signaling pathway", "Positive regulation of vascular permeability", "Positive regulation of vasculature development", "Positive regulation of vasculogenesis", "Positive regulation of vesicle fusion", "Positive regulation of viral genome replication", "Positive regulation of viral life cycle", "Positive regulation of viral process", "Positive regulation of vitamin d receptor signaling pathway", "Positive regulation of voltage gated calcium channel activity", "Positive regulation of wnt signaling pathway", "Positive regulation of wound healing", "Positive regulation of wound healing spreading of epidermal cells", "Positive t cell selection", "Post anal tail morphogenesis", "Post chaperonin tubulin folding pathway", "Post embryonic development", "Post golgi vesicle mediated transport", "Post translational protein modification", "Postreplication repair", "Postsynapse organization", "Postsynapse to nucleus signaling pathway", "Postsynaptic actin cytoskeleton organization", "Postsynaptic cytoskeleton organization", "Postsynaptic membrane organization", "Postsynaptic modulation of chemical synaptic transmission", "Postsynaptic neurotransmitter receptor internalization", "Postsynaptic signal transduction", "Postsynaptic specialization organization", "Posttranscriptional regulation of gene expression", "Posttranslational protein targeting to endoplasmic reticulum membrane", "Posttranslational protein targeting to membrane translocation", "Potassium ion homeostasis", "Potassium ion import across plasma membrane", "Potassium ion transport", "Pre mirna processing", "Prenylation", "Presynapse organization", "Presynaptic active zone organization", "Presynaptic endocytosis", "Presynaptic modulation of chemical synaptic transmission", "Prevention of polyspermy", "Primary alcohol biosynthetic process", "Primary alcohol catabolic process", "Primary alcohol metabolic process", "Primary amino compound biosynthetic process", "Primary amino compound metabolic process", "Primary mirna processing", "Pro b cell differentiation", "Process utilizing autophagic mechanism", "Production of molecular mediator involved in inflammatory response", "Production of molecular mediator of immune response", "Production of sirna involved in rna interference", "Progesterone biosynthetic process", "Progesterone metabolic process", "Progesterone receptor signaling pathway", "Programmed cell death", "Programmed cell death in response to reactive oxygen species", "Programmed cell death involved in cell development", "Programmed necrotic cell death", "Prolactin secretion", "Proline metabolic process", "Pronephros development", "Proprioception", "Prostaglandin transport", "Prostanoid biosynthetic process", "Prostanoid metabolic process", "Prostate gland development", "Prostate gland growth", "Proteasomal protein catabolic process", "Proteasome assembly", "Proteasome mediated ubiquitin dependent protein catabolic process", "Protection from natural killer cell mediated cytotoxicity", "Protection from non homologous end joining at telomere", "Protein acetylation", "Protein activation cascade", "Protein acylation", "Protein adp ribosylation", "Protein auto adp ribosylation", "Protein autophosphorylation", "Protein autoprocessing", "Protein autoubiquitination", "Protein catabolic process", "Protein catabolic process in the vacuole", "Protein complex oligomerization", "Protein containing complex disassembly", "Protein containing complex localization", "Protein containing complex organization", "Protein containing complex remodeling", "Protein de adp ribosylation", "Protein deglycosylation", "Protein demannosylation", "Protein demethylation", "Protein deneddylation", "Protein depalmitoylation", "Protein dephosphorylation", "Protein depolymerization", "Protein destabilization", "Protein desumoylation", "Protein deubiquitination involved in ubiquitin dependent protein catabolic process", "Protein dna complex assembly", "Protein dna complex disassembly", "Protein dna complex subunit organization", "Protein dna covalent cross linking repair", "Protein exit from endoplasmic reticulum", "Protein export from nucleus", "Protein folding", "Protein folding in endoplasmic reticulum", "Protein geranylgeranylation", "Protein heterooligomerization", "Protein heterotetramerization", "Protein hexamerization", "Protein homooligomerization", "Protein homotetramerization", "Protein hydroxylation", "Protein import", "Protein import into mitochondrial matrix", "Protein import into peroxisome matrix", "Protein import into peroxisome membrane", "Protein insertion into er membrane", "Protein insertion into er membrane by stop transfer membrane anchor sequence", "Protein insertion into membrane", "Protein insertion into mitochondrial inner membrane", "Protein insertion into mitochondrial membrane involved in apoptotic signaling pathway", "Protein k11 linked ubiquitination", "Protein k27 linked ubiquitination", "Protein k29 linked ubiquitination", "Protein k48 linked deubiquitination", "Protein k48 linked ubiquitination", "Protein k6 linked ubiquitination", "Protein k63 linked deubiquitination", "Protein k63 linked ubiquitination", "Protein kinase a signaling", "Protein kinase b signaling", "Protein kinase c signaling", "Protein lipid complex assembly", "Protein lipid complex subunit organization", "Protein localization to adherens junction", "Protein localization to axon", "Protein localization to basolateral plasma membrane", "Protein localization to cell cell junction", "Protein localization to cell cortex", "Protein localization to cell junction", "Protein localization to cell periphery", "Protein localization to cell surface", "Protein localization to chromatin", "Protein localization to chromosome", "Protein localization to chromosome centromeric region", "Protein localization to chromosome telomeric region", "Protein localization to ciliary membrane", "Protein localization to cilium", "Protein localization to condensed chromosome", "Protein localization to cytoplasmic stress granule", "Protein localization to cytoskeleton", "Protein localization to early endosome", "Protein localization to endoplasmic reticulum", "Protein localization to endoplasmic reticulum exit site", "Protein localization to endosome", "Protein localization to extracellular region", "Protein localization to golgi apparatus", "Protein localization to lysosome", "Protein localization to membrane raft", "Protein localization to microtubule", "Protein localization to microtubule end", "Protein localization to microtubule organizing center", "Protein localization to mitochondrion", "Protein localization to nuclear body", "Protein localization to nuclear envelope", "Protein localization to nucleolus", "Protein localization to nucleoplasm", "Protein localization to nucleus", "Protein localization to organelle", "Protein localization to perinuclear region of cytoplasm", "Protein localization to phagophore assembly site", "Protein localization to plasma membrane", "Protein localization to postsynapse", "Protein localization to presynapse", "Protein localization to synapse", "Protein localization to vacuole", "Protein mannosylation", "Protein maturation", "Protein maturation by 4fe 4s cluster transfer", "Protein maturation by iron sulfur cluster transfer", "Protein maturation by protein folding", "Protein methylation", "Protein modification by small protein conjugation", "Protein modification by small protein conjugation or removal", "Protein modification by small protein removal", "Protein monoubiquitination", "Protein n linked glycosylation", "Protein neddylation", "Protein nitrosylation", "Protein o linked glycosylation", "Protein o linked glycosylation via serine", "Protein o linked glycosylation via threonine", "Protein o linked mannosylation", "Protein oxidation", "Protein peptidyl prolyl isomerization", "Protein poly adp ribosylation", "Protein polyglutamylation", "Protein polymerization", "Protein polyubiquitination", "Protein polyufmylation", "Protein processing", "Protein processing involved in protein targeting to mitochondrion", "Protein quality control for misfolded or incompletely synthesized proteins", "Protein refolding", "Protein repair", "Protein retention in er lumen", "Protein stabilization", "Protein sumoylation", "Protein targeting", "Protein targeting to lysosome", "Protein targeting to membrane", "Protein targeting to mitochondrion", "Protein targeting to peroxisome", "Protein targeting to vacuole", "Protein tetramerization", "Protein transmembrane import into intracellular organelle", "Protein transmembrane transport", "Protein transport along microtubule", "Protein transport to vacuole involved in ubiquitin dependent protein catabolic process via the multivesicular body sorting pathway", "Protein transport within lipid bilayer", "Protein trimerization", "Protein ufmylation", "Proteoglycan biosynthetic process", "Proteoglycan metabolic process", "Proteolysis", "Proton transmembrane transport", "Proton transporting two sector atpase complex assembly", "Proton transporting v type atpase complex assembly", "Protoporphyrinogen ix biosynthetic process", "Protoporphyrinogen ix metabolic process", "Proximal distal pattern formation", "Proximal distal pattern formation involved in nephron development", "Proximal tubule development", "Pseudopodium organization", "Pseudouridine synthesis", "Pteridine containing compound biosynthetic process", "Pteridine containing compound metabolic process", "Pulmonary artery morphogenesis", "Pulmonary valve development", "Pulmonary valve morphogenesis", "Purine containing compound biosynthetic process", "Purine containing compound catabolic process", "Purine containing compound metabolic process", "Purine containing compound salvage", "Purine containing compound transmembrane transport", "Purine deoxyribonucleoside metabolic process", "Purine deoxyribonucleoside monophosphate catabolic process", "Purine deoxyribonucleoside monophosphate metabolic process", "Purine deoxyribonucleoside triphosphate metabolic process", "Purine deoxyribonucleotide biosynthetic process", "Purine deoxyribonucleotide catabolic process", "Purine deoxyribonucleotide metabolic process", "Purine nucleobase biosynthetic process", "Purine nucleobase metabolic process", "Purine nucleoside biosynthetic process", "Purine nucleoside catabolic process", "Purine nucleoside diphosphate biosynthetic process", "Purine nucleoside metabolic process", "Purine nucleoside monophosphate biosynthetic process", "Purine nucleoside monophosphate catabolic process", "Purine nucleoside monophosphate metabolic process", "Purine nucleoside triphosphate catabolic process", "Purine nucleotide catabolic process", "Purine nucleotide salvage", "Purine nucleotide transport", "Purine ribonucleoside catabolic process", "Purine ribonucleoside metabolic process", "Purine ribonucleoside salvage", "Purine ribonucleotide salvage", "Purinergic nucleotide receptor signaling pathway", "Putrescine metabolic process", "Pyramidal neuron development", "Pyramidal neuron differentiation", "Pyridine containing compound biosynthetic process", "Pyridine containing compound catabolic process", "Pyridine containing compound metabolic process", "Pyridine nucleotide biosynthetic process", "Pyridine nucleotide metabolic process", "Pyrimidine containing compound biosynthetic process", "Pyrimidine containing compound catabolic process", "Pyrimidine containing compound metabolic process", "Pyrimidine containing compound salvage", "Pyrimidine containing compound transmembrane transport", "Pyrimidine deoxyribonucleoside metabolic process", "Pyrimidine deoxyribonucleoside monophosphate biosynthetic process", "Pyrimidine deoxyribonucleoside monophosphate metabolic process", "Pyrimidine deoxyribonucleoside triphosphate metabolic process", "Pyrimidine deoxyribonucleotide biosynthetic process", "Pyrimidine deoxyribonucleotide metabolic process", "Pyrimidine nucleobase biosynthetic process", "Pyrimidine nucleobase catabolic process", "Pyrimidine nucleobase metabolic process", "Pyrimidine nucleoside diphosphate biosynthetic process", "Pyrimidine nucleoside diphosphate metabolic process", "Pyrimidine nucleoside metabolic process", "Pyrimidine nucleoside monophosphate biosynthetic process", "Pyrimidine nucleoside monophosphate metabolic process", "Pyrimidine nucleoside transport", "Pyrimidine nucleoside triphosphate biosynthetic process", "Pyrimidine nucleoside triphosphate metabolic process", "Pyrimidine nucleotide catabolic process", "Pyrimidine nucleotide metabolic process", "Pyrimidine ribonucleoside diphosphate metabolic process", "Pyrimidine ribonucleoside monophosphate metabolic process", "Pyrimidine ribonucleoside triphosphate biosynthetic process", "Pyrimidine ribonucleoside triphosphate metabolic process", "Pyrimidine ribonucleotide biosynthetic process", "Pyrimidine ribonucleotide metabolic process", "Pyroptosis", "Pyruvate metabolic process", "Pyruvate transmembrane transport", "Pyruvate transport", "Quaternary ammonium group transport", "Quinone metabolic process", "R loop disassembly", "Rab protein signal transduction", "Rac protein signal transduction", "Radial glial cell differentiation", "Rap protein signal transduction", "Ras protein signal transduction", "Reactive nitrogen species metabolic process", "Reactive oxygen species biosynthetic process", "Reactive oxygen species metabolic process", "Receptor catabolic process", "Receptor clustering", "Receptor diffusion trapping", "Receptor internalization", "Receptor localization to synapse", "Receptor mediated endocytosis", "Receptor mediated endocytosis involved in cholesterol transport", "Receptor metabolic process", "Receptor recycling", "Receptor signaling pathway via stat", "Recognition of apoptotic cell", "Recombinational repair", "Reelin mediated signaling pathway", "Reflex", "Regeneration", "Regionalization", "Regulated exocytosis", "Regulation by virus of viral protein levels in host cell", "Regulation of 3 utr mediated mrna stabilization", "Regulation of actin cytoskeleton reorganization", "Regulation of actin filament based movement", "Regulation of actin filament based process", "Regulation of actin filament bundle assembly", "Regulation of actin filament length", "Regulation of actin filament organization", "Regulation of actin nucleation", "Regulation of action potential", "Regulation of activin receptor signaling pathway", "Regulation of actomyosin structure organization", "Regulation of acute inflammatory response", "Regulation of acute inflammatory response to antigenic stimulus", "Regulation of acyl coa biosynthetic process", "Regulation of adaptive immune response", "Regulation of adenylate cyclase activating g protein coupled receptor signaling pathway", "Regulation of adenylate cyclase activity", "Regulation of adherens junction organization", "Regulation of aerobic respiration", "Regulation of alcohol biosynthetic process", "Regulation of alpha beta t cell activation", "Regulation of alpha beta t cell differentiation", "Regulation of alternative mrna splicing via spliceosome", "Regulation of amino acid transmembrane transport", "Regulation of amino acid transport", "Regulation of amyloid beta clearance", "Regulation of amyloid fibril formation", "Regulation of amyloid precursor protein catabolic process", "Regulation of anaphase promoting complex dependent catabolic process", "Regulation of anatomical structure morphogenesis", "Regulation of anatomical structure size", "Regulation of androgen receptor signaling pathway", "Regulation of angiotensin levels in blood", "Regulation of animal organ formation", "Regulation of animal organ morphogenesis", "Regulation of anion channel activity", "Regulation of anion transmembrane transport", "Regulation of anion transport", "Regulation of anoikis", "Regulation of antigen receptor mediated signaling pathway", "Regulation of apoptotic cell clearance", "Regulation of apoptotic dna fragmentation", "Regulation of apoptotic signaling pathway", "Regulation of appetite", "Regulation of arachidonic acid secretion", "Regulation of arp2 3 complex mediated actin nucleation", "Regulation of aspartic type endopeptidase activity involved in amyloid precursor protein catabolic process", "Regulation of aspartic type peptidase activity", "Regulation of astrocyte differentiation", "Regulation of atp biosynthetic process", "Regulation of atp dependent activity", "Regulation of atp metabolic process", "Regulation of atpase coupled calcium transmembrane transporter activity", "Regulation of atrial cardiac muscle cell membrane repolarization", "Regulation of attachment of spindle microtubules to kinetochore", "Regulation of autophagy", "Regulation of autophagy of mitochondrion", "Regulation of autophagy of mitochondrion in response to mitochondrial depolarization", "Regulation of axon diameter", "Regulation of axon guidance", "Regulation of axonogenesis", "Regulation of b cell activation", "Regulation of b cell apoptotic process", "Regulation of b cell differentiation", "Regulation of b cell mediated immunity", "Regulation of b cell proliferation", "Regulation of barbed end actin filament capping", "Regulation of behavior", "Regulation of bicellular tight junction assembly", "Regulation of binding", "Regulation of biological process involved in symbiotic interaction", "Regulation of biomineralization", "Regulation of blood brain barrier permeability", "Regulation of blood circulation", "Regulation of blood pressure", "Regulation of bmp signaling pathway", "Regulation of body fluid levels", "Regulation of bone mineralization", "Regulation of bone remodeling", "Regulation of bone resorption", "Regulation of branching involved in lung morphogenesis", "Regulation of branching morphogenesis of a nerve", "Regulation of brown fat cell differentiation", "Regulation of calcineurin mediated signaling", "Regulation of calcium ion dependent exocytosis", "Regulation of calcium ion export across plasma membrane", "Regulation of calcium ion import", "Regulation of calcium ion transmembrane transport", "Regulation of calcium ion transmembrane transporter activity", "Regulation of calcium ion transport", "Regulation of calcium ion transport into cytosol", "Regulation of calcium mediated signaling", "Regulation of camp dependent protein kinase activity", "Regulation of camp mediated signaling", "Regulation of canonical wnt signaling pathway", "Regulation of carbohydrate biosynthetic process", "Regulation of carbohydrate catabolic process", "Regulation of carbohydrate metabolic process", "Regulation of cardiac conduction", "Regulation of cardiac muscle adaptation", "Regulation of cardiac muscle cell action potential", "Regulation of cardiac muscle cell action potential involved in regulation of contraction", "Regulation of cardiac muscle cell membrane potential", "Regulation of cardiac muscle cell membrane repolarization", "Regulation of cardiac muscle cell proliferation", "Regulation of cardiac muscle contraction", "Regulation of cardiac muscle contraction by calcium ion signaling", "Regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion", "Regulation of cardioblast differentiation", "Regulation of cardiocyte differentiation", "Regulation of cartilage development", "Regulation of catabolic process", "Regulation of catecholamine metabolic process", "Regulation of cation channel activity", "Regulation of cation transmembrane transport", "Regulation of cd4 positive alpha beta t cell activation", "Regulation of cd4 positive alpha beta t cell differentiation", "Regulation of cd8 positive alpha beta t cell activation", "Regulation of cdc42 protein signal transduction", "Regulation of cell activation", "Regulation of cell adhesion", "Regulation of cell adhesion mediated by integrin", "Regulation of cell aging", "Regulation of cell cell adhesion", "Regulation of cell cell adhesion mediated by cadherin", "Regulation of cell cell adhesion mediated by integrin", "Regulation of cell communication by electrical coupling", "Regulation of cell communication by electrical coupling involved in cardiac conduction", "Regulation of cell cycle", "Regulation of cell cycle checkpoint", "Regulation of cell cycle g1 s phase transition", "Regulation of cell cycle g2 m phase transition", "Regulation of cell cycle phase transition", "Regulation of cell cycle process", "Regulation of cell death", "Regulation of cell development", "Regulation of cell differentiation", "Regulation of cell division", "Regulation of cell growth involved in cardiac muscle cell development", "Regulation of cell junction assembly", "Regulation of cell killing", "Regulation of cell matrix adhesion", "Regulation of cell maturation", "Regulation of cell migration involved in sprouting angiogenesis", "Regulation of cell morphogenesis", "Regulation of cell morphogenesis involved in differentiation", "Regulation of cell population proliferation", "Regulation of cell projection assembly", "Regulation of cell projection organization", "Regulation of cell projection size", "Regulation of cell shape", "Regulation of cell size", "Regulation of cell substrate adhesion", "Regulation of cell substrate junction organization", "Regulation of cellular amide metabolic process", "Regulation of cellular amine metabolic process", "Regulation of cellular amino acid metabolic process", "Regulation of cellular carbohydrate catabolic process", "Regulation of cellular carbohydrate metabolic process", "Regulation of cellular component biogenesis", "Regulation of cellular component movement", "Regulation of cellular component size", "Regulation of cellular ketone metabolic process", "Regulation of cellular localization", "Regulation of cellular macromolecule biosynthetic process", "Regulation of cellular ph", "Regulation of cellular protein catabolic process", "Regulation of cellular respiration", "Regulation of cellular response to growth factor stimulus", "Regulation of cellular response to heat", "Regulation of cellular response to hypoxia", "Regulation of cellular response to insulin stimulus", "Regulation of cellular response to osmotic stress", "Regulation of cellular response to stress", "Regulation of cellular response to transforming growth factor beta stimulus", "Regulation of cellular response to vascular endothelial growth factor stimulus", "Regulation of centriole replication", "Regulation of centromere complex assembly", "Regulation of centrosome cycle", "Regulation of chaperone mediated autophagy", "Regulation of chemokine mediated signaling pathway", "Regulation of chemotaxis", "Regulation of chloride transport", "Regulation of cholesterol biosynthetic process", "Regulation of cholesterol efflux", "Regulation of cholesterol esterification", "Regulation of cholesterol metabolic process", "Regulation of chondrocyte differentiation", "Regulation of chromatin assembly", "Regulation of chromatin assembly or disassembly", "Regulation of chromatin binding", "Regulation of chromatin organization", "Regulation of chromosome condensation", "Regulation of chromosome organization", "Regulation of chromosome segregation", "Regulation of chromosome separation", "Regulation of cilium assembly", "Regulation of cilium beat frequency", "Regulation of cilium beat frequency involved in ciliary motility", "Regulation of cilium dependent cell motility", "Regulation of cilium movement", "Regulation of circadian rhythm", "Regulation of clathrin dependent endocytosis", "Regulation of coagulation", "Regulation of collagen fibril organization", "Regulation of collagen metabolic process", "Regulation of collateral sprouting", "Regulation of complement activation", "Regulation of complement dependent cytotoxicity", "Regulation of connective tissue replacement", "Regulation of core promoter binding", "Regulation of cyclase activity", "Regulation of cyclic nucleotide phosphodiesterase activity", "Regulation of cyclin dependent protein kinase activity", "Regulation of cysteine type endopeptidase activity", "Regulation of cysteine type endopeptidase activity involved in apoptotic signaling pathway", "Regulation of cysteine type endopeptidase activity involved in execution phase of apoptosis", "Regulation of cytokinesis", "Regulation of cytoplasmic mrna processing body assembly", "Regulation of cytoplasmic translation", "Regulation of cytoplasmic translational elongation", "Regulation of cytoplasmic translational initiation", "Regulation of cytoplasmic transport", "Regulation of cytoskeleton organization", "Regulation of cytosolic calcium ion concentration", "Regulation of defense response", "Regulation of defense response to virus", "Regulation of defense response to virus by host", "Regulation of dendrite development", "Regulation of dendrite extension", "Regulation of dendrite morphogenesis", "Regulation of dendritic cell chemotaxis", "Regulation of dendritic cell differentiation", "Regulation of dendritic spine development", "Regulation of dendritic spine maintenance", "Regulation of dendritic spine morphogenesis", "Regulation of deoxyribonuclease activity", "Regulation of dephosphorylation", "Regulation of developmental growth", "Regulation of digestive system process", "Regulation of dna binding", "Regulation of dna binding transcription factor activity", "Regulation of dna biosynthetic process", "Regulation of dna catabolic process", "Regulation of dna damage checkpoint", "Regulation of dna damage response signal transduction by p53 class mediator", "Regulation of dna damage response signal transduction by p53 class mediator resulting in transcription of p21 class mediator", "Regulation of dna demethylation", "Regulation of dna dependent dna replication", "Regulation of dna dependent dna replication initiation", "Regulation of dna directed dna polymerase activity", "Regulation of dna duplex unwinding", "Regulation of dna helicase activity", "Regulation of dna ligation", "Regulation of dna metabolic process", "Regulation of dna methylation", "Regulation of dna methylation dependent heterochromatin assembly", "Regulation of dna primase activity", "Regulation of dna recombination", "Regulation of dna repair", "Regulation of dna replication", "Regulation of dna strand elongation", "Regulation of dna templated transcription elongation", "Regulation of dna templated transcription in response to stress", "Regulation of dna templated transcription initiation", "Regulation of dna topoisomerase atp hydrolyzing activity", "Regulation of dopamine receptor signaling pathway", "Regulation of dopaminergic neuron differentiation", "Regulation of double strand break repair", "Regulation of double strand break repair via homologous recombination", "Regulation of double strand break repair via nonhomologous end joining", "Regulation of early endosome to late endosome transport", "Regulation of electron transfer activity", "Regulation of embryonic development", "Regulation of endocrine process", "Regulation of endocytic recycling", "Regulation of endocytosis", "Regulation of endodeoxyribonuclease activity", "Regulation of endodermal cell differentiation", "Regulation of endoplasmic reticulum stress induced intrinsic apoptotic signaling pathway", "Regulation of endoplasmic reticulum tubular network organization", "Regulation of endoplasmic reticulum unfolded protein response", "Regulation of endosome to plasma membrane protein transport", "Regulation of endothelial cell chemotaxis", "Regulation of endothelial cell development", "Regulation of endothelial cell differentiation", "Regulation of endothelial cell migration", "Regulation of entry of bacterium into host cell", "Regulation of epidermal growth factor activated receptor activity", "Regulation of epidermis development", "Regulation of epithelial cell apoptotic process", "Regulation of epithelial cell differentiation", "Regulation of epithelial cell differentiation involved in kidney development", "Regulation of epithelial cell migration", "Regulation of epithelial cell proliferation involved in lung morphogenesis", "Regulation of epithelial to mesenchymal transition", "Regulation of er associated ubiquitin dependent protein catabolic process", "Regulation of er to golgi vesicle mediated transport", "Regulation of erad pathway", "Regulation of erbb signaling pathway", "Regulation of erythrocyte differentiation", "Regulation of establishment of planar polarity", "Regulation of establishment of protein localization", "Regulation of establishment of protein localization to chromosome", "Regulation of establishment of protein localization to mitochondrion", "Regulation of establishment or maintenance of cell polarity", "Regulation of excretion", "Regulation of execution phase of apoptosis", "Regulation of exit from mitosis", "Regulation of exocytosis", "Regulation of exosomal secretion", "Regulation of extent of cell growth", "Regulation of extracellular matrix assembly", "Regulation of extracellular matrix disassembly", "Regulation of extracellular matrix organization", "Regulation of extrinsic apoptotic signaling pathway", "Regulation of extrinsic apoptotic signaling pathway in absence of ligand", "Regulation of extrinsic apoptotic signaling pathway via death domain receptors", "Regulation of fat cell differentiation", "Regulation of fat cell proliferation", "Regulation of fatty acid beta oxidation", "Regulation of fatty acid biosynthetic process", "Regulation of fatty acid metabolic process", "Regulation of fatty acid oxidation", "Regulation of fatty acid transport", "Regulation of fc gamma receptor signaling pathway involved in phagocytosis", "Regulation of fc receptor mediated stimulatory signaling pathway", "Regulation of feeding behavior", "Regulation of fertilization", "Regulation of fibroblast growth factor receptor signaling pathway", "Regulation of fibroblast migration", "Regulation of filopodium assembly", "Regulation of focal adhesion disassembly", "Regulation of g protein coupled receptor signaling pathway", "Regulation of g0 to g1 transition", "Regulation of gastrulation", "Regulation of gene expression by genomic imprinting", "Regulation of gene expression epigenetic", "Regulation of gene silencing by rna", "Regulation of generation of precursor metabolites and energy", "Regulation of genetic imprinting", "Regulation of germ cell proliferation", "Regulation of glial cell apoptotic process", "Regulation of glial cell differentiation", "Regulation of glial cell migration", "Regulation of glial cell proliferation", "Regulation of gliogenesis", "Regulation of glucagon secretion", "Regulation of glucan biosynthetic process", "Regulation of glucocorticoid biosynthetic process", "Regulation of glucocorticoid metabolic process", "Regulation of glucocorticoid receptor signaling pathway", "Regulation of glucocorticoid secretion", "Regulation of gluconeogenesis", "Regulation of glucose import", "Regulation of glucose metabolic process", "Regulation of glucose transmembrane transport", "Regulation of glucosylceramidase activity", "Regulation of glutamate receptor clustering", "Regulation of glycogen catabolic process", "Regulation of glycogen metabolic process", "Regulation of glycogen starch synthase activity", "Regulation of glycolytic process", "Regulation of glycoprotein metabolic process", "Regulation of golgi organization", "Regulation of golgi to plasma membrane protein transport", "Regulation of gonad development", "Regulation of granulocyte chemotaxis", "Regulation of growth", "Regulation of gtp binding", "Regulation of gtpase activity", "Regulation of guanyl nucleotide exchange factor activity", "Regulation of hair cycle", "Regulation of hair follicle development", "Regulation of heart contraction", "Regulation of heart growth", "Regulation of heart rate", "Regulation of heart rate by cardiac conduction", "Regulation of heart rate by chemical signal", "Regulation of helicase activity", "Regulation of hematopoietic progenitor cell differentiation", "Regulation of hematopoietic stem cell differentiation", "Regulation of hematopoietic stem cell proliferation", "Regulation of hemoglobin biosynthetic process", "Regulation of hemopoiesis", "Regulation of hepatic stellate cell activation", "Regulation of hepatocyte apoptotic process", "Regulation of hepatocyte proliferation", "Regulation of heterotypic cell cell adhesion", "Regulation of hexokinase activity", "Regulation of high voltage gated calcium channel activity", "Regulation of hippo signaling", "Regulation of histamine secretion by mast cell", "Regulation of histone deacetylation", "Regulation of histone h2b ubiquitination", "Regulation of histone h3 k14 acetylation", "Regulation of histone h3 k27 methylation", "Regulation of histone h3 k4 methylation", "Regulation of histone h3 k9 methylation", "Regulation of histone h3 k9 trimethylation", "Regulation of histone h4 acetylation", "Regulation of histone h4 k16 acetylation", "Regulation of histone methylation", "Regulation of histone modification", "Regulation of histone phosphorylation", "Regulation of histone ubiquitination", "Regulation of homotypic cell cell adhesion", "Regulation of hormone biosynthetic process", "Regulation of hormone levels", "Regulation of hormone metabolic process", "Regulation of hormone secretion", "Regulation of humoral immune response", "Regulation of hyaluronan biosynthetic process", "Regulation of hydrogen peroxide biosynthetic process", "Regulation of hydrogen peroxide mediated programmed cell death", "Regulation of hydrogen peroxide metabolic process", "Regulation of hydrolase activity", "Regulation of i kappab phosphorylation", "Regulation of icosanoid secretion", "Regulation of immune effector process", "Regulation of immune response", "Regulation of immune system process", "Regulation of immunoglobulin production", "Regulation of inclusion body assembly", "Regulation of inflammatory response", "Regulation of inflammatory response to antigenic stimulus", "Regulation of innate immune response", "Regulation of inositol 1 4 5 trisphosphate sensitive calcium release channel activity", "Regulation of insulin like growth factor receptor signaling pathway", "Regulation of insulin receptor signaling pathway", "Regulation of insulin secretion", "Regulation of insulin secretion involved in cellular response to glucose stimulus", "Regulation of integrin mediated signaling pathway", "Regulation of interleukin 1 mediated signaling pathway", "Regulation of intestinal absorption", "Regulation of intestinal lipid absorption", "Regulation of intracellular estrogen receptor signaling pathway", "Regulation of intracellular lipid transport", "Regulation of intracellular protein transport", "Regulation of intracellular signal transduction", "Regulation of intracellular steroid hormone receptor signaling pathway", "Regulation of intracellular transport", "Regulation of intrinsic apoptotic signaling pathway", "Regulation of intrinsic apoptotic signaling pathway by p53 class mediator", "Regulation of intrinsic apoptotic signaling pathway in response to dna damage", "Regulation of intrinsic apoptotic signaling pathway in response to dna damage by p53 class mediator", "Regulation of intrinsic apoptotic signaling pathway in response to osmotic stress", "Regulation of inward rectifier potassium channel activity", "Regulation of ion transmembrane transport", "Regulation of ion transport", "Regulation of ire1 mediated unfolded protein response", "Regulation of iron ion transmembrane transport", "Regulation of iron ion transport", "Regulation of isomerase activity", "Regulation of isotype switching", "Regulation of jnk cascade", "Regulation of jun kinase activity", "Regulation of keratinocyte differentiation", "Regulation of keratinocyte migration", "Regulation of keratinocyte proliferation", "Regulation of ketone biosynthetic process", "Regulation of kidney development", "Regulation of l glutamate import across plasma membrane", "Regulation of lamellipodium assembly", "Regulation of lamellipodium morphogenesis", "Regulation of lamellipodium organization", "Regulation of leukocyte adhesion to vascular endothelial cell", "Regulation of leukocyte apoptotic process", "Regulation of leukocyte chemotaxis", "Regulation of leukocyte degranulation", "Regulation of leukocyte differentiation", "Regulation of leukocyte mediated cytotoxicity", "Regulation of leukocyte mediated immunity", "Regulation of leukocyte migration", "Regulation of leukocyte proliferation", "Regulation of ligase activity", "Regulation of lipase activity", "Regulation of lipid biosynthetic process", "Regulation of lipid catabolic process", "Regulation of lipid kinase activity", "Regulation of lipid localization", "Regulation of lipid metabolic process", "Regulation of lipid storage", "Regulation of lipid transport", "Regulation of lipid transporter activity", "Regulation of lipophagy", "Regulation of lipopolysaccharide mediated signaling pathway", "Regulation of lipoprotein lipase activity", "Regulation of lipoprotein metabolic process", "Regulation of lipoprotein particle clearance", "Regulation of locomotion involved in locomotory behavior", "Regulation of long chain fatty acid import across plasma membrane", "Regulation of long chain fatty acid import into cell", "Regulation of long term neuronal synaptic plasticity", "Regulation of long term synaptic depression", "Regulation of long term synaptic potentiation", "Regulation of low density lipoprotein particle clearance", "Regulation of lyase activity", "Regulation of lymphocyte activation", "Regulation of lymphocyte apoptotic process", "Regulation of lymphocyte chemotaxis", "Regulation of lymphocyte differentiation", "Regulation of lymphocyte mediated immunity", "Regulation of lymphocyte migration", "Regulation of lymphoid progenitor cell differentiation", "Regulation of lysosomal lumen ph", "Regulation of lysosomal protein catabolic process", "Regulation of lysosome organization", "Regulation of macroautophagy", "Regulation of macrophage activation", "Regulation of macrophage apoptotic process", "Regulation of macrophage chemotaxis", "Regulation of macrophage differentiation", "Regulation of macrophage migration", "Regulation of macrophage proliferation", "Regulation of maintenance of sister chromatid cohesion", "Regulation of male gonad development", "Regulation of mammary gland epithelial cell proliferation", "Regulation of map kinase activity", "Regulation of mast cell activation", "Regulation of mast cell activation involved in immune response", "Regulation of matrix metallopeptidase secretion", "Regulation of mda 5 signaling pathway", "Regulation of megakaryocyte differentiation", "Regulation of meiotic cell cycle", "Regulation of meiotic cell cycle phase transition", "Regulation of meiotic nuclear division", "Regulation of membrane depolarization", "Regulation of membrane depolarization during action potential", "Regulation of membrane depolarization during cardiac muscle cell action potential", "Regulation of membrane invagination", "Regulation of membrane lipid distribution", "Regulation of membrane permeability", "Regulation of membrane potential", "Regulation of membrane protein ectodomain proteolysis", "Regulation of membrane repolarization", "Regulation of membrane repolarization during action potential", "Regulation of membrane repolarization during cardiac muscle cell action potential", "Regulation of membrane tubulation", "Regulation of mesenchymal cell proliferation", "Regulation of mesenchymal stem cell differentiation", "Regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis", "Regulation of mesoderm development", "Regulation of metal ion transport", "Regulation of metalloendopeptidase activity", "Regulation of metallopeptidase activity", "Regulation of metaphase plate congression", "Regulation of microglial cell activation", "Regulation of microtubule based movement", "Regulation of microtubule based process", "Regulation of microtubule binding", "Regulation of microtubule cytoskeleton organization", "Regulation of microtubule depolymerization", "Regulation of microtubule nucleation", "Regulation of microtubule polymerization", "Regulation of microtubule polymerization or depolymerization", "Regulation of microvillus assembly", "Regulation of microvillus length", "Regulation of microvillus organization", "Regulation of mirna catabolic process", "Regulation of mirna metabolic process", "Regulation of mirna transcription", "Regulation of mitochondrial atp synthesis coupled electron transport", "Regulation of mitochondrial dna replication", "Regulation of mitochondrial electron transport nadh to ubiquinone", "Regulation of mitochondrial fission", "Regulation of mitochondrial fusion", "Regulation of mitochondrial gene expression", "Regulation of mitochondrial membrane permeability", "Regulation of mitochondrial membrane permeability involved in apoptotic process", "Regulation of mitochondrial membrane potential", "Regulation of mitochondrial mrna stability", "Regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway", "Regulation of mitochondrial rna catabolic process", "Regulation of mitochondrion organization", "Regulation of mitophagy", "Regulation of mitotic cell cycle", "Regulation of mitotic cell cycle phase transition", "Regulation of mitotic cell cycle spindle assembly checkpoint", "Regulation of mitotic centrosome separation", "Regulation of mitotic cytokinesis", "Regulation of mitotic nuclear division", "Regulation of mitotic recombination", "Regulation of mitotic sister chromatid segregation", "Regulation of mitotic spindle assembly", "Regulation of modification of postsynaptic structure", "Regulation of modification of synaptic structure", "Regulation of monocyte chemotaxis", "Regulation of monocyte differentiation", "Regulation of mononuclear cell migration", "Regulation of monooxygenase activity", "Regulation of morphogenesis of a branching structure", "Regulation of morphogenesis of an epithelium", "Regulation of motor neuron apoptotic process", "Regulation of mrna 3 end processing", "Regulation of mrna binding", "Regulation of mrna catabolic process", "Regulation of mrna export from nucleus", "Regulation of mrna metabolic process", "Regulation of mrna polyadenylation", "Regulation of mrna processing", "Regulation of mrna splicing via spliceosome", "Regulation of multicellular organism growth", "Regulation of multicellular organismal development", "Regulation of muscle adaptation", "Regulation of muscle cell differentiation", "Regulation of muscle contraction", "Regulation of muscle hypertrophy", "Regulation of muscle organ development", "Regulation of muscle system process", "Regulation of myelination", "Regulation of myeloid cell apoptotic process", "Regulation of myeloid cell differentiation", "Regulation of myeloid leukocyte differentiation", "Regulation of myeloid leukocyte mediated immunity", "Regulation of myoblast differentiation", "Regulation of myoblast fusion", "Regulation of myosin light chain phosphatase activity", "Regulation of myotube differentiation", "Regulation of nad p h oxidase activity", "Regulation of nadp metabolic process", "Regulation of natural killer cell activation", "Regulation of natural killer cell mediated immunity", "Regulation of necrotic cell death", "Regulation of nervous system development", "Regulation of nervous system process", "Regulation of neural precursor cell proliferation", "Regulation of neuroblast proliferation", "Regulation of neurogenesis", "Regulation of neuromuscular junction development", "Regulation of neuron differentiation", "Regulation of neuron migration", "Regulation of neuron projection arborization", "Regulation of neuron projection development", "Regulation of neuron projection regeneration", "Regulation of neuronal action potential", "Regulation of neuronal synaptic plasticity", "Regulation of neurotransmitter levels", "Regulation of neurotransmitter receptor activity", "Regulation of neurotransmitter transport", "Regulation of neurotransmitter uptake", "Regulation of neurotrophin trk receptor signaling pathway", "Regulation of neutrophil chemotaxis", "Regulation of neutrophil migration", "Regulation of nik nf kappab signaling", "Regulation of nitric oxide metabolic process", "Regulation of nitric oxide synthase activity", "Regulation of nk t cell activation", "Regulation of nk t cell differentiation", "Regulation of nmda receptor activity", "Regulation of non motile cilium assembly", "Regulation of notch signaling pathway", "Regulation of nuclear cell cycle dna replication", "Regulation of nuclear division", "Regulation of nuclear transcribed mrna catabolic process deadenylation dependent decay", "Regulation of nuclear transcribed mrna catabolic process nonsense mediated decay", "Regulation of nuclear transcribed mrna poly a tail shortening", "Regulation of nuclease activity", "Regulation of nucleobase containing compound transport", "Regulation of nucleocytoplasmic transport", "Regulation of nucleotide binding oligomerization domain containing 2 signaling pathway", "Regulation of nucleotide binding oligomerization domain containing signaling pathway", "Regulation of nucleotide biosynthetic process", "Regulation of nucleotide metabolic process", "Regulation of oligodendrocyte differentiation", "Regulation of oocyte maturation", "Regulation of organ growth", "Regulation of organelle assembly", "Regulation of organelle organization", "Regulation of organelle transport along microtubule", "Regulation of organic acid transport", "Regulation of ossification", "Regulation of osteoblast differentiation", "Regulation of osteoblast proliferation", "Regulation of osteoclast differentiation", "Regulation of oxidative phosphorylation", "Regulation of oxidative stress induced cell death", "Regulation of oxidative stress induced intrinsic apoptotic signaling pathway", "Regulation of oxidoreductase activity", "Regulation of p38mapk cascade", "Regulation of pattern recognition receptor signaling pathway", "Regulation of peptidase activity", "Regulation of peptide transport", "Regulation of peptidyl lysine acetylation", "Regulation of peptidyl serine phosphorylation", "Regulation of peptidyl serine phosphorylation of stat protein", "Regulation of peptidyl threonine phosphorylation", "Regulation of peptidyl tyrosine phosphorylation", "Regulation of perk mediated unfolded protein response", "Regulation of ph", "Regulation of phagocytosis", "Regulation of phenotypic switching", "Regulation of phosphatase activity", "Regulation of phosphatidylcholine biosynthetic process", "Regulation of phosphatidylcholine metabolic process", "Regulation of phosphatidylinositol 3 kinase activity", "Regulation of phosphatidylinositol 3 kinase signaling", "Regulation of phosphatidylinositol dephosphorylation", "Regulation of phospholipase a2 activity", "Regulation of phospholipase activity", "Regulation of phospholipase c activity", "Regulation of phospholipid biosynthetic process", "Regulation of phospholipid catabolic process", "Regulation of phospholipid metabolic process", "Regulation of phospholipid translocation", "Regulation of phospholipid transport", "Regulation of phosphoprotein phosphatase activity", "Regulation of phosphorus metabolic process", "Regulation of pinocytosis", "Regulation of plasma lipoprotein particle levels", "Regulation of plasma membrane organization", "Regulation of plasminogen activation", "Regulation of platelet activation", "Regulation of platelet aggregation", "Regulation of platelet derived growth factor receptor signaling pathway", "Regulation of podosome assembly", "Regulation of polysaccharide metabolic process", "Regulation of post translational protein modification", "Regulation of postsynapse organization", "Regulation of postsynaptic membrane neurotransmitter receptor levels", "Regulation of postsynaptic membrane potential", "Regulation of postsynaptic neurotransmitter receptor internalization", "Regulation of potassium ion import", "Regulation of potassium ion transmembrane transporter activity", "Regulation of potassium ion transport", "Regulation of presynapse organization", "Regulation of presynaptic cytosolic calcium ion concentration", "Regulation of pro b cell differentiation", "Regulation of production of molecular mediator of immune response", "Regulation of production of small rna involved in gene silencing by rna", "Regulation of programmed necrotic cell death", "Regulation of prostaglandin secretion", "Regulation of proteasomal protein catabolic process", "Regulation of proteasomal ubiquitin dependent protein catabolic process", "Regulation of protein acetylation", "Regulation of protein adp ribosylation", "Regulation of protein autophosphorylation", "Regulation of protein autoubiquitination", "Regulation of protein binding", "Regulation of protein catabolic process", "Regulation of protein catabolic process in the vacuole", "Regulation of protein complex stability", "Regulation of protein containing complex assembly", "Regulation of protein containing complex disassembly", "Regulation of protein deacetylation", "Regulation of protein dephosphorylation", "Regulation of protein depolymerization", "Regulation of protein deubiquitination", "Regulation of protein exit from endoplasmic reticulum", "Regulation of protein export from nucleus", "Regulation of protein folding", "Regulation of protein glycosylation", "Regulation of protein import", "Regulation of protein k63 linked ubiquitination", "Regulation of protein kinase a signaling", "Regulation of protein kinase activity", "Regulation of protein kinase c signaling", "Regulation of protein lipidation", "Regulation of protein localization", "Regulation of protein localization to cell cortex", "Regulation of protein localization to cell periphery", "Regulation of protein localization to cell surface", "Regulation of protein localization to centrosome", "Regulation of protein localization to chromatin", "Regulation of protein localization to chromosome telomeric region", "Regulation of protein localization to cilium", "Regulation of protein localization to endosome", "Regulation of protein localization to membrane", "Regulation of protein localization to nucleolus", "Regulation of protein localization to nucleus", "Regulation of protein localization to plasma membrane", "Regulation of protein localization to synapse", "Regulation of protein maturation", "Regulation of protein modification by small protein conjugation or removal", "Regulation of protein modification process", "Regulation of protein monoubiquitination", "Regulation of protein neddylation", "Regulation of protein phosphorylation", "Regulation of protein polymerization", "Regulation of protein polyubiquitination", "Regulation of protein secretion", "Regulation of protein serine threonine kinase activity", "Regulation of protein stability", "Regulation of protein sumoylation", "Regulation of protein targeting", "Regulation of protein targeting to membrane", "Regulation of protein tyrosine kinase activity", "Regulation of protein tyrosine phosphatase activity", "Regulation of proteolysis", "Regulation of proton transport", "Regulation of rac protein signal transduction", "Regulation of ras protein signal transduction", "Regulation of reactive oxygen species biosynthetic process", "Regulation of reactive oxygen species metabolic process", "Regulation of receptor binding", "Regulation of receptor catabolic process", "Regulation of receptor clustering", "Regulation of receptor internalization", "Regulation of receptor localization to synapse", "Regulation of receptor mediated endocytosis", "Regulation of receptor mediated endocytosis involved in cholesterol transport", "Regulation of receptor recycling", "Regulation of receptor signaling pathway via stat", "Regulation of regulated secretory pathway", "Regulation of relaxation of muscle", "Regulation of release of cytochrome c from mitochondria", "Regulation of release of sequestered calcium ion into cytosol", "Regulation of removal of superoxide radicals", "Regulation of renal system process", "Regulation of reproductive process", "Regulation of respiratory burst", "Regulation of respiratory gaseous exchange", "Regulation of respiratory gaseous exchange by nervous system process", "Regulation of respiratory system process", "Regulation of response to biotic stimulus", "Regulation of response to cytokine stimulus", "Regulation of response to dna damage stimulus", "Regulation of response to endoplasmic reticulum stress", "Regulation of response to external stimulus", "Regulation of response to extracellular stimulus", "Regulation of response to food", "Regulation of response to interferon gamma", "Regulation of response to osmotic stress", "Regulation of response to oxidative stress", "Regulation of response to reactive oxygen species", "Regulation of response to stress", "Regulation of response to tumor cell", "Regulation of response to wounding", "Regulation of retinal ganglion cell axon guidance", "Regulation of retinoic acid receptor signaling pathway", "Regulation of retrograde protein transport er to cytosol", "Regulation of retrograde transport endosome to golgi", "Regulation of rho dependent protein serine threonine kinase activity", "Regulation of rho protein signal transduction", "Regulation of rhodopsin mediated signaling pathway", "Regulation of ribonuclease activity", "Regulation of ribosome biogenesis", "Regulation of rig i signaling pathway", "Regulation of rna binding", "Regulation of rna export from nucleus", "Regulation of rna polymerase ii regulatory region sequence specific dna binding", "Regulation of rna polymerase ii transcription preinitiation complex assembly", "Regulation of rna splicing", "Regulation of rrna processing", "Regulation of ruffle assembly", "Regulation of ryanodine sensitive calcium release channel activity", "Regulation of sarcomere organization", "Regulation of secondary heart field cardioblast proliferation", "Regulation of secondary metabolic process", "Regulation of secretion", "Regulation of sequestering of triglyceride", "Regulation of sequestering of zinc ion", "Regulation of short term neuronal synaptic plasticity", "Regulation of signal transduction by p53 class mediator", "Regulation of signaling receptor activity", "Regulation of sister chromatid cohesion", "Regulation of skeletal muscle adaptation", "Regulation of skeletal muscle cell differentiation", "Regulation of skeletal muscle contraction", "Regulation of skeletal muscle contraction by calcium ion signaling", "Regulation of skeletal muscle fiber development", "Regulation of skeletal muscle tissue development", "Regulation of smad protein complex assembly", "Regulation of smad protein signal transduction", "Regulation of small gtpase mediated signal transduction", "Regulation of small molecule metabolic process", "Regulation of smooth muscle cell chemotaxis", "Regulation of smooth muscle cell differentiation", "Regulation of smooth muscle contraction", "Regulation of smoothened signaling pathway", "Regulation of sodium ion transmembrane transport", "Regulation of sodium ion transport", "Regulation of sodium proton antiporter activity", "Regulation of somatic stem cell population maintenance", "Regulation of somitogenesis", "Regulation of sphingolipid biosynthetic process", "Regulation of spindle assembly", "Regulation of spindle organization", "Regulation of spontaneous synaptic transmission", "Regulation of sprouting angiogenesis", "Regulation of srebp signaling pathway", "Regulation of stem cell differentiation", "Regulation of stem cell population maintenance", "Regulation of stem cell proliferation", "Regulation of steroid biosynthetic process", "Regulation of steroid hormone biosynthetic process", "Regulation of steroid hormone secretion", "Regulation of steroid metabolic process", "Regulation of sterol transport", "Regulation of stress activated protein kinase signaling cascade", "Regulation of stress granule assembly", "Regulation of striated muscle cell differentiation", "Regulation of striated muscle contraction", "Regulation of substrate adhesion dependent cell spreading", "Regulation of sulfur metabolic process", "Regulation of superoxide anion generation", "Regulation of superoxide dismutase activity", "Regulation of superoxide metabolic process", "Regulation of supramolecular fiber organization", "Regulation of synapse assembly", "Regulation of synapse maturation", "Regulation of synapse structural plasticity", "Regulation of synapse structure or activity", "Regulation of synaptic plasticity", "Regulation of synaptic transmission dopaminergic", "Regulation of synaptic transmission gabaergic", "Regulation of synaptic transmission glutamatergic", "Regulation of synaptic vesicle endocytosis", "Regulation of synaptic vesicle exocytosis", "Regulation of synaptic vesicle priming", "Regulation of synaptic vesicle recycling", "Regulation of syncytium formation by plasma membrane fusion", "Regulation of system process", "Regulation of systemic arterial blood pressure", "Regulation of systemic arterial blood pressure by circulatory renin angiotensin", "Regulation of systemic arterial blood pressure by endothelin", "Regulation of systemic arterial blood pressure by hormone", "Regulation of systemic arterial blood pressure by norepinephrine epinephrine", "Regulation of systemic arterial blood pressure by renin angiotensin", "Regulation of systemic arterial blood pressure mediated by a chemical signal", "Regulation of t cell activation", "Regulation of t cell activation via t cell receptor contact with antigen bound to mhc molecule on antigen presenting cell", "Regulation of t cell apoptotic process", "Regulation of t cell chemotaxis", "Regulation of t cell differentiation", "Regulation of t cell differentiation in thymus", "Regulation of t cell mediated cytotoxicity", "Regulation of t cell mediated immune response to tumor cell", "Regulation of t cell mediated immunity", "Regulation of t cell migration", "Regulation of t cell proliferation", "Regulation of t cell receptor signaling pathway", "Regulation of t circle formation", "Regulation of t helper 1 cell differentiation", "Regulation of t helper 1 type immune response", "Regulation of t helper 2 cell differentiation", "Regulation of t helper cell differentiation", "Regulation of tau protein kinase activity", "Regulation of telomerase activity", "Regulation of telomere capping", "Regulation of telomere maintenance", "Regulation of telomere maintenance via telomere lengthening", "Regulation of tetrapyrrole metabolic process", "Regulation of the force of heart contraction", "Regulation of thymocyte apoptotic process", "Regulation of tissue remodeling", "Regulation of tolerance induction", "Regulation of toll like receptor 3 signaling pathway", "Regulation of toll like receptor 4 signaling pathway", "Regulation of toll like receptor 7 signaling pathway", "Regulation of toll like receptor 9 signaling pathway", "Regulation of toll like receptor signaling pathway", "Regulation of tor signaling", "Regulation of torc2 signaling", "Regulation of trail activated apoptotic signaling pathway", "Regulation of trans synaptic signaling", "Regulation of transcription by glucose", "Regulation of transcription by rna polymerase i", "Regulation of transcription by rna polymerase iii", "Regulation of transcription elongation from rna polymerase ii promoter", "Regulation of transcription from rna polymerase ii promoter in response to hypoxia", "Regulation of transcription from rna polymerase ii promoter in response to oxidative stress", "Regulation of transcription involved in g1 s transition of mitotic cell cycle", "Regulation of transcription of nucleolar large rrna by rna polymerase i", "Regulation of transcription regulatory region dna binding", "Regulation of transferase activity", "Regulation of transforming growth factor beta activation", "Regulation of transforming growth factor beta1 production", "Regulation of translation at synapse modulating synaptic transmission", "Regulation of translation in response to endoplasmic reticulum stress", "Regulation of translation in response to stress", "Regulation of translation initiation in response to endoplasmic reticulum stress", "Regulation of translational elongation", "Regulation of translational fidelity", "Regulation of translational initiation", "Regulation of translational initiation by eif2 alpha phosphorylation", "Regulation of translational initiation in response to stress", "Regulation of translational termination", "Regulation of transmembrane receptor protein serine threonine kinase signaling pathway", "Regulation of transmembrane transport", "Regulation of transmission of nerve impulse", "Regulation of transport", "Regulation of transporter activity", "Regulation of transposition", "Regulation of triglyceride biosynthetic process", "Regulation of triglyceride metabolic process", "Regulation of tube size", "Regulation of tumor necrosis factor mediated signaling pathway", "Regulation of type b pancreatic cell development", "Regulation of type i interferon mediated signaling pathway", "Regulation of ubiquitin dependent protein catabolic process", "Regulation of ubiquitin protein ligase activity", "Regulation of ubiquitin protein transferase activity", "Regulation of ubiquitin specific protease activity", "Regulation of unsaturated fatty acid biosynthetic process", "Regulation of urine volume", "Regulation of vacuole organization", "Regulation of vascular associated smooth muscle cell differentiation", "Regulation of vascular endothelial growth factor receptor signaling pathway", "Regulation of vascular permeability", "Regulation of vascular wound healing", "Regulation of vasculature development", "Regulation of vasculogenesis", "Regulation of vasoconstriction", "Regulation of ventricular cardiac muscle cell action potential", "Regulation of vesicle fusion", "Regulation of vesicle mediated transport", "Regulation of vesicle size", "Regulation of viral entry into host cell", "Regulation of viral genome replication", "Regulation of viral induced cytoplasmic pattern recognition receptor signaling pathway", "Regulation of viral process", "Regulation of viral transcription", "Regulation of vitamin d receptor signaling pathway", "Regulation of vitamin metabolic process", "Regulation of voltage gated calcium channel activity", "Regulation of water loss via skin", "Regulation of wnt signaling pathway", "Regulation of wound healing", "Regulation of wound healing spreading of epidermal cells", "Relaxation of cardiac muscle", "Relaxation of muscle", "Release of cytochrome c from mitochondria", "Release of sequestered calcium ion into cytosol by endoplasmic reticulum", "Renal absorption", "Renal filtration", "Renal sodium excretion", "Renal sodium ion absorption", "Renal sodium ion transport", "Renal system process", "Renal system vasculature development", "Renal system vasculature morphogenesis", "Renal tubular secretion", "Renal tubule development", "Renal vesicle development", "Renal vesicle formation", "Renal water homeostasis", "Replication born double strand break repair via sister chromatid exchange", "Replication fork processing", "Replicative senescence", "Reproduction", "Reproductive behavior", "Reproductive system development", "Rescue of stalled ribosome", "Resolution of meiotic recombination intermediates", "Respiratory burst", "Respiratory burst involved in defense response", "Respiratory burst involved in inflammatory response", "Respiratory chain complex iii assembly", "Respiratory chain complex iv assembly", "Respiratory electron transport chain", "Respiratory gaseous exchange by respiratory system", "Respiratory system development", "Respiratory system process", "Response to abiotic stimulus", "Response to acetylcholine", "Response to acid chemical", "Response to acidic ph", "Response to actinomycin d", "Response to activity", "Response to alcohol", "Response to aldosterone", "Response to alkaloid", "Response to amine", "Response to amino acid starvation", "Response to ammonium ion", "Response to amphetamine", "Response to amyloid beta", "Response to angiotensin", "Response to antibiotic", "Response to arsenic containing substance", "Response to arsenite ion", "Response to atp", "Response to auditory stimulus", "Response to axon injury", "Response to bacterium", "Response to bmp", "Response to cadmium ion", "Response to caffeine", "Response to calcium ion", "Response to camp", "Response to carbohydrate", "Response to catecholamine", "Response to cell cycle checkpoint signaling", "Response to cgmp", "Response to chemokine", "Response to cisplatin", "Response to cobalt ion", "Response to cocaine", "Response to cold", "Response to copper ion", "Response to corticosteroid", "Response to corticosterone", "Response to cortisol", "Response to cytokine", "Response to dexamethasone", "Response to dietary excess", "Response to dopamine", "Response to dsrna", "Response to electrical stimulus", "Response to endogenous stimulus", "Response to endoplasmic reticulum stress", "Response to epidermal growth factor", "Response to estradiol", "Response to estrogen", "Response to ethanol", "Response to ether", "Response to extracellular stimulus", "Response to fatty acid", "Response to fibroblast growth factor", "Response to fluid shear stress", "Response to folic acid", "Response to follicle stimulating hormone", "Response to food", "Response to forskolin", "Response to fungus", "Response to gamma radiation", "Response to glucagon", "Response to glycoside", "Response to gonadotropin", "Response to granulocyte macrophage colony stimulating factor", "Response to growth factor", "Response to growth hormone", "Response to heat", "Response to heparin", "Response to hepatocyte growth factor", "Response to histamine", "Response to hormone", "Response to human chorionic gonadotropin", "Response to hydrogen peroxide", "Response to hydroperoxide", "Response to hydrostatic pressure", "Response to hydroxyurea", "Response to hyperoxia", "Response to immobilization stress", "Response to increased oxygen levels", "Response to indole 3 methanol", "Response to inorganic substance", "Response to insecticide", "Response to insulin", "Response to interferon alpha", "Response to interferon beta", "Response to interferon gamma", "Response to interleukin 1", "Response to interleukin 12", "Response to interleukin 17", "Response to interleukin 3", "Response to interleukin 4", "Response to interleukin 6", "Response to interleukin 7", "Response to ionizing radiation", "Response to iron ion", "Response to ischemia", "Response to isoquinoline alkaloid", "Response to ketone", "Response to l ascorbic acid", "Response to l glutamate", "Response to l phenylalanine derivative", "Response to lead ion", "Response to lectin", "Response to leptin", "Response to leucine", "Response to leukemia inhibitory factor", "Response to light intensity", "Response to light stimulus", "Response to lipid", "Response to lipoteichoic acid", "Response to lithium ion", "Response to manganese ion", "Response to mechanical stimulus", "Response to mercury ion", "Response to metal ion", "Response to methylmercury", "Response to mineralocorticoid", "Response to misfolded protein", "Response to mitochondrial depolarisation", "Response to molecule of bacterial origin", "Response to monosaccharide", "Response to muramyl dipeptide", "Response to muscle activity", "Response to muscle stretch", "Response to nerve growth factor", "Response to nicotine", "Response to nitric oxide", "Response to nitrogen compound", "Response to nitrosative stress", "Response to nutrient", "Response to oleic acid", "Response to organic cyclic compound", "Response to osmotic stress", "Response to oxidative stress", "Response to oxygen containing compound", "Response to oxygen glucose deprivation", "Response to oxygen levels", "Response to oxygen radical", "Response to pain", "Response to peptide", "Response to peptide hormone", "Response to peptidoglycan", "Response to ph", "Response to phorbol 13 acetate 12 myristate", "Response to platelet derived growth factor", "Response to potassium ion", "Response to progesterone", "Response to prostaglandin", "Response to prostaglandin e", "Response to purine containing compound", "Response to radiation", "Response to reactive oxygen species", "Response to redox state", "Response to retinoic acid", "Response to salt", "Response to salt stress", "Response to selenium ion", "Response to sodium arsenite", "Response to starvation", "Response to steroid hormone", "Response to sterol depletion", "Response to temperature stimulus", "Response to testosterone", "Response to thyroglobulin triiodothyronine", "Response to thyroid hormone", "Response to thyroxine", "Response to topologically incorrect protein", "Response to toxic substance", "Response to transforming growth factor beta", "Response to tumor cell", "Response to tumor necrosis factor", "Response to type i interferon", "Response to uv", "Response to uv a", "Response to uv b", "Response to uv c", "Response to virus", "Response to vitamin", "Response to vitamin a", "Response to vitamin d", "Response to vitamin e", "Response to vitamin k", "Response to water", "Response to wounding", "Response to x ray", "Response to xenobiotic stimulus", "Response to yeast", "Response to zinc ion", "Reticulophagy", "Retina development in camera type eye", "Retina homeostasis", "Retina layer formation", "Retina morphogenesis in camera type eye", "Retina vasculature development in camera type eye", "Retina vasculature morphogenesis in camera type eye", "Retinal cell apoptotic process", "Retinal cone cell differentiation", "Retinal ganglion cell axon guidance", "Retinal metabolic process", "Retinal pigment epithelium development", "Retinal rod cell development", "Retinal rod cell differentiation", "Retinoic acid metabolic process", "Retinoic acid receptor signaling pathway", "Retinol metabolic process", "Retrograde axonal transport", "Retrograde transport endosome to golgi", "Retrograde vesicle mediated transport golgi to endoplasmic reticulum", "Reverse cholesterol transport", "Reversible differentiation", "Rho protein signal transduction", "Rhodopsin mediated signaling pathway", "Rhythmic behavior", "Rhythmic process", "Riboflavin metabolic process", "Ribonucleoprotein complex biogenesis", "Ribonucleoprotein complex disassembly", "Ribonucleoprotein complex localization", "Ribonucleoprotein complex subunit organization", "Ribonucleoside catabolic process", "Ribonucleoside diphosphate biosynthetic process", "Ribonucleoside diphosphate catabolic process", "Ribonucleoside diphosphate metabolic process", "Ribonucleoside metabolic process", "Ribonucleoside monophosphate biosynthetic process", "Ribonucleoside monophosphate catabolic process", "Ribonucleoside monophosphate metabolic process", "Ribonucleoside triphosphate biosynthetic process", "Ribonucleoside triphosphate metabolic process", "Ribonucleotide catabolic process", "Ribose phosphate biosynthetic process", "Ribose phosphate metabolic process", "Ribosomal large subunit assembly", "Ribosomal large subunit biogenesis", "Ribosomal large subunit export from nucleus", "Ribosomal small subunit assembly", "Ribosomal small subunit biogenesis", "Ribosomal small subunit export from nucleus", "Ribosomal subunit export from nucleus", "Ribosome assembly", "Ribosome associated ubiquitin dependent protein catabolic process", "Ribosome biogenesis", "Ribosome disassembly", "Rig i signaling pathway", "Righting reflex", "Rna 3 end processing", "Rna 3 uridylation", "Rna 5 end processing", "Rna capping", "Rna catabolic process", "Rna decapping", "Rna dependent dna biosynthetic process", "Rna destabilization", "Rna export from nucleus", "Rna guanine n7 methylation", "Rna import into mitochondrion", "Rna interference", "Rna localization", "Rna mediated gene silencing by inhibition of translation", "Rna methylation", "Rna modification", "Rna phosphodiester bond hydrolysis", "Rna phosphodiester bond hydrolysis endonucleolytic", "Rna phosphodiester bond hydrolysis exonucleolytic", "Rna polyadenylation", "Rna polymerase i preinitiation complex assembly", "Rna polymerase ii preinitiation complex assembly", "Rna processing", "Rna secondary structure unwinding", "Rna splicing", "Rna splicing via endonucleolytic cleavage and ligation", "Rna splicing via transesterification reactions", "Rna stabilization", "Rna surveillance", "Roof of mouth development", "Rostrocaudal neural tube patterning", "Roundabout signaling pathway", "Rrna 3 end processing", "Rrna 5 end processing", "Rrna base methylation", "Rrna catabolic process", "Rrna metabolic process", "Rrna methylation", "Rrna modification", "Rrna pseudouridine synthesis", "Rrna transcription", "Rrna transport", "Ruffle assembly", "Ruffle organization", "S adenosylmethionine cycle", "S adenosylmethionine metabolic process", "Salivary gland development", "Sarcomere organization", "Sarcoplasmic reticulum calcium ion transport", "Satellite cell activation involved in skeletal muscle regeneration", "Scarna localization to cajal body", "Scf dependent proteasomal ubiquitin dependent protein catabolic process", "Schwann cell development", "Schwann cell differentiation", "Schwann cell proliferation", "Second messenger mediated signaling", "Secondary alcohol metabolic process", "Secondary metabolic process", "Secondary metabolite biosynthetic process", "Secretion", "Secretion by tissue", "Secretion of lysosomal enzymes", "Secretory granule localization", "Secretory granule organization", "Segment specification", "Segmentation", "Selective autophagy", "Self proteolysis", "Semaphorin plexin signaling pathway", "Semaphorin plexin signaling pathway involved in neuron projection guidance", "Semi lunar valve development", "Sensory organ development", "Sensory organ morphogenesis", "Sensory perception", "Sensory perception of light stimulus", "Sensory perception of mechanical stimulus", "Sensory perception of pain", "Sensory system development", "Septum primum development", "Sequestering of actin monomers", "Sequestering of calcium ion", "Sequestering of iron ion", "Sequestering of metal ion", "Sequestering of triglyceride", "Sequestering of zinc ion", "Serine family amino acid biosynthetic process", "Serine family amino acid catabolic process", "Serine family amino acid metabolic process", "Serine phosphorylation of stat protein", "Serine transport", "Serotonin metabolic process", "Sertoli cell development", "Sertoli cell differentiation", "Sex determination", "Sex differentiation", "Short chain fatty acid catabolic process", "Short chain fatty acid metabolic process", "Short term memory", "Signal peptide processing", "Signal release", "Signal transduction by p53 class mediator", "Signal transduction in absence of ligand", "Signal transduction in response to dna damage", "Signal transduction involved in regulation of gene expression", "Signaling receptor ligand precursor processing", "Single fertilization", "Single strand break repair", "Single stranded viral rna replication via double stranded dna intermediate", "Sister chromatid cohesion", "Sister chromatid segregation", "Skeletal muscle acetylcholine gated channel clustering", "Skeletal muscle adaptation", "Skeletal muscle cell differentiation", "Skeletal muscle cell proliferation", "Skeletal muscle contraction", "Skeletal muscle fiber differentiation", "Skeletal muscle organ development", "Skeletal muscle satellite cell activation", "Skeletal muscle tissue regeneration", "Skeletal myofibril assembly", "Skeletal system development", "Skeletal system morphogenesis", "Skin development", "Skin epidermis development", "Skin morphogenesis", "Sleep", "Smad protein complex assembly", "Smad protein signal transduction", "Small gtpase mediated signal transduction", "Small molecule biosynthetic process", "Small molecule catabolic process", "Small molecule metabolic process", "Small nucleolar ribonucleoprotein complex assembly", "Small rna loading onto risc", "Smooth muscle adaptation", "Smooth muscle cell apoptotic process", "Smooth muscle cell chemotaxis", "Smooth muscle cell differentiation", "Smooth muscle cell migration", "Smooth muscle cell proliferation", "Smooth muscle contraction", "Smooth muscle tissue development", "Smoothened signaling pathway", "Snare complex assembly", "Sno s rna metabolic process", "Sno s rna processing", "Snorna localization", "Snrna metabolic process", "Snrna modification", "Snrna processing", "Snrna transport", "Sodium independent organic anion transport", "Sodium ion export across plasma membrane", "Sodium ion homeostasis", "Sodium ion import across plasma membrane", "Sodium ion transmembrane transport", "Sodium ion transport", "Somatic diversification of immune receptors", "Somatic diversification of immune receptors via somatic mutation", "Somatic diversification of immunoglobulins", "Somatic diversification of immunoglobulins involved in immune response", "Somatic diversification of t cell receptor genes", "Somatic stem cell population maintenance", "Somite development", "Somite rostral caudal axis specification", "Somitogenesis", "Specification of animal organ identity", "Specification of symmetry", "Sperm capacitation", "Sperm dna condensation", "Sperm egg recognition", "Sperm motility", "Spermatid differentiation", "Spermatid nucleus differentiation", "Spermatogenesis exchange of chromosomal proteins", "Spermidine metabolic process", "Spermine metabolic process", "Sphingoid metabolic process", "Sphingolipid biosynthetic process", "Sphingolipid mediated signaling pathway", "Sphingolipid metabolic process", "Sphingolipid translocation", "Sphingomyelin biosynthetic process", "Sphingomyelin catabolic process", "Sphingomyelin metabolic process", "Sphingosine biosynthetic process", "Spinal cord development", "Spinal cord motor neuron differentiation", "Spindle assembly", "Spindle assembly involved in female meiosis", "Spindle elongation", "Spindle localization", "Spindle midzone assembly", "Spindle organization", "Spliceosomal complex assembly", "Spliceosomal conformational changes to generate catalytic conformation", "Spliceosomal snrnp assembly", "Spliceosomal tri snrnp complex assembly", "Spontaneous synaptic transmission", "Sprouting angiogenesis", "Srp dependent cotranslational protein targeting to membrane", "Srp dependent cotranslational protein targeting to membrane signal sequence recognition", "Srp dependent cotranslational protein targeting to membrane translocation", "Startle response", "Stem cell differentiation", "Stem cell division", "Stem cell proliferation", "Steroid biosynthetic process", "Steroid catabolic process", "Steroid esterification", "Steroid hormone biosynthetic process", "Steroid hormone mediated signaling pathway", "Steroid hormone secretion", "Steroid metabolic process", "Sterol biosynthetic process", "Sterol homeostasis", "Sterol import", "Sterol metabolic process", "Sterol transport", "Stress activated protein kinase signaling cascade", "Stress fiber assembly", "Stress granule assembly", "Stress granule disassembly", "Stress induced premature senescence", "Stress response to metal ion", "Striated muscle adaptation", "Striated muscle cell apoptotic process", "Striated muscle cell development", "Striated muscle cell differentiation", "Striated muscle cell proliferation", "Striated muscle contraction", "Striatum development", "Subpallium development", "Substantia nigra development", "Substrate adhesion dependent cell spreading", "Substrate dependent cell migration", "Substrate dependent cell migration cell extension", "Substrate independent telencephalic tangential migration", "Subtelomeric heterochromatin assembly", "Succinate metabolic process", "Succinate transmembrane transport", "Succinyl coa metabolic process", "Suckling behavior", "Sugar mediated signaling pathway", "Sulfate transport", "Sulfur amino acid biosynthetic process", "Sulfur amino acid catabolic process", "Sulfur amino acid metabolic process", "Sulfur compound biosynthetic process", "Sulfur compound catabolic process", "Sulfur compound metabolic process", "Sulfur compound transport", "Superoxide anion generation", "Superoxide metabolic process", "Suppression of viral release by host", "Supramolecular fiber organization", "Sympathetic ganglion development", "Sympathetic nervous system development", "Synapse assembly", "Synapse maturation", "Synapse organization", "Synapse pruning", "Synaptic assembly at neuromuscular junction", "Synaptic signaling", "Synaptic transmission dopaminergic", "Synaptic transmission gabaergic", "Synaptic transmission glutamatergic", "Synaptic vesicle budding", "Synaptic vesicle clustering", "Synaptic vesicle cytoskeletal transport", "Synaptic vesicle docking", "Synaptic vesicle endosomal processing", "Synaptic vesicle exocytosis", "Synaptic vesicle localization", "Synaptic vesicle maturation", "Synaptic vesicle membrane organization", "Synaptic vesicle priming", "Synaptic vesicle recycling", "Synaptic vesicle recycling via endosome", "Synaptic vesicle transport", "Synaptic vesicle uncoating", "Synaptonemal complex organization", "Syncytium formation", "T cell activation", "T cell activation involved in immune response", "T cell activation via t cell receptor contact with antigen bound to mhc molecule on antigen presenting cell", "T cell apoptotic process", "T cell chemotaxis", "T cell cytokine production", "T cell differentiation", "T cell differentiation in thymus", "T cell differentiation involved in immune response", "T cell extravasation", "T cell homeostasis", "T cell lineage commitment", "T cell mediated cytotoxicity", "T cell mediated immune response to tumor cell", "T cell mediated immunity", "T cell migration", "T cell proliferation", "T cell proliferation involved in immune response", "T cell receptor signaling pathway", "T cell selection", "T cell tolerance induction", "T helper 1 cell differentiation", "T helper 1 type immune response", "T helper 17 cell differentiation", "T helper 17 cell lineage commitment", "T helper 17 type immune response", "T helper 2 cell differentiation", "T helper cell lineage commitment", "T tubule organization", "Tail anchored membrane protein insertion into er membrane", "Tangential migration from the subventricular zone to the olfactory bulb", "Taxis", "Telencephalon development", "Telencephalon glial cell migration", "Telencephalon regionalization", "Telomerase holoenzyme complex assembly", "Telomerase rna localization", "Telomere capping", "Telomere maintenance", "Telomere maintenance in response to dna damage", "Telomere maintenance via recombination", "Telomere maintenance via semi conservative replication", "Telomere maintenance via telomere lengthening", "Telomere organization", "Temperature homeostasis", "Terminal button organization", "Terpenoid biosynthetic process", "Terpenoid metabolic process", "Tertiary alcohol metabolic process", "Tetrahydrobiopterin metabolic process", "Tetrahydrofolate biosynthetic process", "Tetrahydrofolate interconversion", "Tetrahydrofolate metabolic process", "Tetrapyrrole biosynthetic process", "Tetrapyrrole catabolic process", "Tetrapyrrole metabolic process", "Thalamus development", "Thiamine containing compound metabolic process", "Thiamine transport", "Thioester biosynthetic process", "Thioester metabolic process", "Threonine catabolic process", "Threonine metabolic process", "Thrombin activated receptor signaling pathway", "Thymocyte apoptotic process", "Thymus development", "Thyroid gland development", "Thyroid hormone generation", "Thyroid hormone mediated signaling pathway", "Thyroid hormone metabolic process", "Tight junction organization", "Tissue development", "Tissue migration", "Tissue morphogenesis", "Tissue regeneration", "Tissue remodeling", "Tolerance induction", "Toll like receptor 3 signaling pathway", "Toll like receptor 4 signaling pathway", "Toll like receptor 7 signaling pathway", "Toll like receptor 8 signaling pathway", "Toll like receptor 9 signaling pathway", "Toll like receptor signaling pathway", "Tongue development", "Tongue morphogenesis", "Tooth mineralization", "Tor signaling", "Torc1 signaling", "Torc2 signaling", "Toxin metabolic process", "Toxin transport", "Trabecula formation", "Trabecula morphogenesis", "Trachea development", "Trachea formation", "Trachea morphogenesis", "Trail activated apoptotic signaling pathway", "Transcription by rna polymerase i", "Transcription by rna polymerase iii", "Transcription coupled nucleotide excision repair", "Transcription dependent tethering of rna polymerase ii gene dna at nuclear periphery", "Transcription elongation from rna polymerase i promoter", "Transcription elongation from rna polymerase ii promoter", "Transcription factor catabolic process", "Transcription initiation from rna polymerase i promoter", "Transcription initiation from rna polymerase ii promoter", "Transcription initiation from rna polymerase iii promoter", "Transcription preinitiation complex assembly", "Transcytosis", "Transepithelial chloride transport", "Transepithelial transport", "Transferrin transport", "Transforming growth factor beta activation", "Transforming growth factor beta production", "Transforming growth factor beta receptor signaling pathway", "Transforming growth factor beta1 production", "Transition between fast and slow fiber", "Transition metal ion homeostasis", "Transition metal ion transport", "Translational elongation", "Translational initiation", "Translational readthrough", "Translational termination", "Translesion synthesis", "Translocation of molecules into host", "Transmembrane receptor protein serine threonine kinase signaling pathway", "Transmembrane receptor protein tyrosine kinase signaling pathway", "Transmembrane receptor protein tyrosine phosphatase signaling pathway", "Transmembrane transport", "Transmission of nerve impulse", "Transport along microtubule", "Transport of virus", "Transposition", "Transposition rna mediated", "Tricarboxylic acid cycle", "Tricarboxylic acid metabolic process", "Trigeminal ganglion development", "Trigeminal nerve development", "Trigeminal nerve morphogenesis", "Triglyceride biosynthetic process", "Triglyceride metabolic process", "Tripartite regional subdivision", "Tripeptide transport", "Trivalent inorganic anion homeostasis", "Trna 3 end processing", "Trna 5 end processing", "Trna 5 leader removal", "Trna aminoacylation for mitochondrial protein translation", "Trna catabolic process", "Trna metabolic process", "Trna methylation", "Trna modification", "Trna processing", "Trna pseudouridine synthesis", "Trna thio modification", "Trna threonylcarbamoyladenosine metabolic process", "Trna transcription", "Trna transport", "Trna wobble base modification", "Trna wobble uridine modification", "Trophectodermal cell differentiation", "Trophoblast cell migration", "Trophoblast giant cell differentiation", "Tryptophan transport", "Tube development", "Tube formation", "Tube morphogenesis", "Tubulin complex assembly", "Tubulin deacetylation", "Tumor necrosis factor mediated signaling pathway", "Tumor necrosis factor superfamily cytokine production", "Type 2 immune response", "Type b pancreatic cell apoptotic process", "Type b pancreatic cell development", "Type i interferon production", "Type i pneumocyte differentiation", "Tyrosine catabolic process", "Tyrosine metabolic process", "Tyrosine phosphorylation of stat protein", "U4 snrna 3 end processing", "Ubiquinone metabolic process", "Ubiquitin dependent endocytosis", "Ubiquitin dependent erad pathway", "Ubiquitin dependent protein catabolic process via the multivesicular body sorting pathway", "Ubiquitin dependent smad protein catabolic process", "Ubiquitin independent protein catabolic process via the multivesicular body sorting pathway", "Ubiquitin recycling", "Udp glucose metabolic process", "Udp n acetylglucosamine biosynthetic process", "Udp n acetylglucosamine metabolic process", "Ump biosynthetic process", "Unsaturated fatty acid biosynthetic process", "Unsaturated fatty acid metabolic process", "Urate metabolic process", "Urea cycle", "Urea metabolic process", "Ureter development", "Urogenital system development", "Uronic acid metabolic process", "Uterus development", "Uterus morphogenesis", "Utp biosynthetic process", "Utp metabolic process", "Uv damage excision repair", "Uv protection", "V d j recombination", "Vacuolar acidification", "Vacuolar localization", "Vacuolar proton transporting v type atpase complex assembly", "Vacuolar transport", "Vacuole organization", "Valine metabolic process", "Vascular associated smooth muscle cell apoptotic process", "Vascular associated smooth muscle cell differentiation", "Vascular associated smooth muscle cell migration", "Vascular associated smooth muscle cell proliferation", "Vascular associated smooth muscle contraction", "Vascular endothelial cell proliferation", "Vascular endothelial growth factor production", "Vascular endothelial growth factor receptor 2 signaling pathway", "Vascular endothelial growth factor receptor signaling pathway", "Vascular endothelial growth factor signaling pathway", "Vascular process in circulatory system", "Vascular transport", "Vascular wound healing", "Vasculature development", "Vasculogenesis", "Vasoconstriction", "Vasodilation", "Ventral spinal cord development", "Ventricular cardiac muscle cell action potential", "Ventricular cardiac muscle cell development", "Ventricular cardiac muscle cell differentiation", "Ventricular cardiac muscle cell membrane repolarization", "Ventricular cardiac muscle tissue development", "Ventricular cardiac muscle tissue morphogenesis", "Ventricular compact myocardium morphogenesis", "Ventricular septum development", "Ventricular septum morphogenesis", "Ventricular system development", "Ventricular trabecula myocardium morphogenesis", "Very long chain fatty acid catabolic process", "Very long chain fatty acid metabolic process", "Very low density lipoprotein particle assembly", "Vesicle budding from membrane", "Vesicle cargo loading", "Vesicle cytoskeletal trafficking", "Vesicle docking", "Vesicle docking involved in exocytosis", "Vesicle fusion to plasma membrane", "Vesicle fusion with golgi apparatus", "Vesicle localization", "Vesicle mediated transport", "Vesicle mediated transport between endosomal compartments", "Vesicle mediated transport in synapse", "Vesicle mediated transport to the plasma membrane", "Vesicle organization", "Vesicle targeting", "Vesicle targeting rough er to cis golgi", "Vesicle targeting to from or within golgi", "Vesicle tethering", "Vesicle tethering to golgi", "Vesicle transport along microtubule", "Vesicle uncoating", "Vestibulocochlear nerve development", "Vestibulocochlear nerve morphogenesis", "Viral budding", "Viral gene expression", "Viral genome replication", "Viral life cycle", "Viral process", "Viral protein processing", "Viral release from host cell", "Viral rna genome replication", "Viral transcription", "Viral translation", "Viral translational termination reinitiation", "Virion assembly", "Virion attachment to host cell", "Visual behavior", "Vitamin b6 metabolic process", "Vitamin biosynthetic process", "Vitamin catabolic process", "Vitamin d metabolic process", "Vitamin d receptor signaling pathway", "Vitamin k metabolic process", "Vitamin metabolic process", "Vitamin transmembrane transport", "Vitamin transport", "Vocalization behavior", "Voluntary musculoskeletal movement", "Walking behavior", "Water homeostasis", "Water soluble vitamin biosynthetic process", "Water soluble vitamin metabolic process", "Water transport", "White fat cell differentiation", "Wnt protein secretion", "Wnt signaling pathway involved in heart development", "Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation", "Wound healing", "Wound healing involved in inflammatory response", "Wound healing spreading of epidermal cells", "Xenobiotic catabolic process", "Xenobiotic export", "Xenobiotic metabolic process", "Xenobiotic transport", "Xenobiotic transport across blood brain barrier", "Xenophagy", "Xmp metabolic process", "Zinc ion homeostasis", "Zinc ion transport", "Zymogen activation", "Zymogen inhibition"], "available_proteins": ["AAAS", "AAMP", "AARS", "AARS2", "AASDHPPT", "AATF", "ABCB1", "ABCB7", "ABCD3", "ABCE1", "ABCF1", "ABCF3", "ABHD10", "ABHD12", "ABHD14B", "ABHD6", "ABI1", "ABRAXAS2", "ACAA2", "ACACA", "ACACB", "ACAD9", "ACADM", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACIN1", "ACLY", "ACO2", "ACOT13", "ACOT7", "ACOT9", "ACOX1", "ACOX3", "ACP1", "ACP2", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN2", "ACTN4", "ACTR1A", "ACTR2", "ACTR3", "ADAR", "ADD1", "ADD3", "ADH5", "ADI1", "ADK", "ADNP", "ADPGK", "ADPRHL2", "ADRM1", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGK", "AGL", "AGPAT1", "AGPS", "AHCY", "AHCYL1", "AHNAK", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AK3", "AKAP1", "AKAP12", "AKAP13", "AKAP17A", "AKAP8", "AKAP8L", "AKR1A1", "AKR1B1", "AKR7A2", "AKT2", "ALDH18A1", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALG1", "ALG12", "ALKBH5", "AMOT", "ANAPC1", "ANAPC10", "ANAPC5", "ANAPC7", "ANKLE2", "ANKRD17", "ANLN", "ANO10", "ANP32A", "ANP32B", "ANXA1", "ANXA11", "ANXA2", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP1M1", "AP1S2", "AP2A1", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "APEH", "APEX1", "APEX2", "API5", "APLP2", "APOL2", "APOO", "APOOL", "APP", "APRT", "AQR", "ARCN1", "ARF4", "ARFGAP1", "ARFGAP2", "ARFIP1", "ARFIP2", "ARHGAP17", "ARHGDIA", "ARHGEF2", "ARID1A", "ARID3B", "ARIH1", "ARIH2", "ARL1", "ARL2", "ARL3", "ARL6IP1", "ARL6IP5", "ARMC10", "ARMC6", "ARMCX3", "ARMT1", "ARPC1A", "ARPC2", "ARPC3", "ARPC4", "ARSA", "ARV1", "ASAH1", "ASCC2", "ASCC3", "ASH2L", "ASNA1", "ASNS", "ASPH", "ASPSCR1", "ASRGL1", "ATAD1", "ATAD3A", "ATAD3B", "ATG3", "ATIC", "ATL2", "ATP13A1", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2C1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6", "ATP6AP1", "ATP6AP2", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1D", "ATP6V1E1", "ATP6V1G1", "ATP6V1H", "ATP7B", "ATPAF1", "ATPIF1", "ATXN10", "ATXN2L", "AUP1", "AURKA", "B4GAT1", "BAG3", "BAG5", "BAG6", "BAIAP2", "BANF1", "BAZ1A", "BAZ1B", "BCAP31", "BCAS3", "BCCIP", "BCLAF1", "BCS1L", "BICD2", "BIRC6", "BLMH", "BLVRA", "BMS1", "BOLA2*", "BOP1", "BPNT1", "BPTF", "BRAP", "BRAT1", "BRD1", "BRD2", "BRIX1", "BSG", "BTAF1", "BTF3", "BUB1B", "BUB3", "BUD23", "BUD31", "BYSL", "BZW1", "BZW2", "C12orf73", "C17orf75", "C19orf70", "C1QBP", "C5orf51", "CAB39", "CACUL1", "CACYBP", "CAD", "CALCOCO1", "CALD1", "CALM3", "CALR", "CAMK1", "CAMK2G", "CAND1", "CAND2", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPNS1", "CAPRIN1", "CAPZA1", "CAPZA2", "CAPZB", "CARM1", "CARS", "CASK", "CAST", "CBL", "CBR1", "CBX1", "CBX2", "CBX3", "CBX5", "CCAR1", "CCAR2", "CCDC124", "CCDC22", "CCDC47", "CCDC6", "CCNB1", "CCNB2", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2AP", "CDC123", "CDC20", "CDC23", "CDC25C", "CDC27", "CDC34", "CDC37", "CDC40", "CDC42", "CDC5L", "CDC73", "CDCA8", "CDK1", "CDK2", "CDK4", "CDK5", "CDK5RAP3", "CDK6", "CDKN2AIP", "CDX2", "CEBPZ", "CENPF", "CENPP", "CEP55", "CEPT1", "CERS2", "CETN2", "CFAP20", "CFL1", "CFL2", "CHAC2", "CHAF1A", "CHAF1B", "CHAMP1", "CHCHD3", "CHD4", "CHERP", "CHID1", "CHKA", "CHM", "CHMP2A", "CHMP2B", "CHMP7", "CHORDC1", "CHRAC1", "CHST14", "CHUK", "CIAPIN1", "CIRBP", "CISD2", "CIZ1", "CKAP2", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLASP2", "CLCC1", "CLCN3", "CLCN7", "CLGN", "CLIC1", "CLIC4", "CLINT1", "CLIP1", "CLN5", "CLNS1A", "CLPB", "CLPP", "CLPTM1", "CLPTM1L", "CLPX", "CLTC", "CLUH", "CMAS", "CMPK1", "CMTR1", "CNDP2", "CNN2", "CNN3", "CNNM4", "CNOT1", "CNOT2", "CNOT3", "CNOT4", "CNOT7", "CNOT9", "CNP", "CNPY2", "COIL", "COL4A3BP", "COLEC12", "COLGALT1", "COMT", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS7A", "COPS7B", "COPS8", "COPZ1", "COQ3", "COQ8A", "COQ9", "CORO1A", "CORO1C", "CORO7", "COTL1", "COX2", "COX4I1", "COX5A", "COX6C", "COX7A2", "CPD", "CPNE1", "CPNE3", "CPOX", "CPSF1", "CPSF3", "CPSF6", "CPSF7", "CPT2", "CPVL", "CRK", "CRKL", "CRNKL1", "CRTAP", "CRYZ", "CS", "CSDE1", "CSE1L", "CSGALNACT2", "CSK", "CSNK1A1", "CSNK2A1", "CSNK2A2", "CSNK2B", "CSTB", "CSTF1", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTBS", "CTH", "CTNNA1", "CTNNAL1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTPS2", "CTSA", "CTSB", "CTSC", "CTTN", "CTU2", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CWF19L1", "CXADR", "CXorf56", "CXorf57", "CYB5B", "CYB5D2", "CYB5R1", "CYB5R3", "CYC1", "CYFIP1", "CYP51A1", "DAP3", "DARS", "DARS2", "DAZAP1", "DBN1", "DBNL", "DCAF1", "DCAF7", "DCAKD", "DCD", "DCPS", "DCTN1", "DCTN2", "DCTN3", "DCTPP1", "DCUN1D4", "DCXR", "DDB1", "DDI2", "DDOST", "DDRGK1", "DDT", "DDX1", "DDX10", "DDX17", "DDX18", "DDX20", "DDX21", "DDX23", "DDX27", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX51", "DDX52", "DDX54", "DDX56", "DDX6", "DEK", "DENR", "DERL1", "DFFA", "DHCR24", "DHCR7", "DHFR", "DHRS7", "DHX15", "DHX16", "DHX29", "DHX30", "DHX36", "DHX37", "DHX8", "DHX9", "DIABLO", "DIAPH1", "DIAPH2", "DIAPH3", "DIDO1", "DIEXF", "DIMT1", "DIS3", "DKC1", "DLAT", "DLD", "DLST", "DNA2", "DNAAF5", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC2", "DNAJC3", "DNAJC7", "DNAJC9", "DNASE2", "DNM1L", "DNM2", "DNMT1", "DNPH1", "DNTTIP2", "DOCK7", "DOHH", "DPH2", "DPH5", "DPM1", "DPP3", "DPP9", "DPY30", "DPYSL2", "DPYSL5", "DR1", "DRG1", "DRG2", "DSC1", "DSC3", "DSG2", "DSP", "DST", "DSTN", "DTYMK", "DUSP12", "DUSP3", "DUSP9", "DUT", "DYNC1H1", "DYNC1LI1", "DYNC1LI2", "DYNC2H1", "DYNLL1", "EBNA1BP2", "ECD", "ECE1", "ECH1", "ECHS1", "ECI1", "ECI2", "ECSIT", "EDC3", "EDC4", "EDF1", "EDRF1", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EFHD1", "EFL1", "EFTUD2", "EHD1", "EHD4", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2D", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A3", "EIF4B", "EIF4E", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "ELAC2", "ELAVL1", "ELMO2", "ELMOD2", "ELOA", "ELOB", "ELOC", "ELP1", "ELP2", "ELP3", "ELP4", "EMC1", "EMC2", "EMC7", "EMD", "EMG1", "ENAH", "ENDOD1", "ENO1", "ENO2", "ENSA", "EPB41", "EPB41L2", "EPB41L5", "EPDR1", "EPHA7", "EPHX1", "EPHX2", "EPPK1", "EPRS", "EPS15", "EPS15L1", "ERAL1", "ERAP1", "ERCC2", "ERG28", "ERGIC3", "ERH", "ERI1", "ERLIN1", "ERLIN2", "ERMP1", "ERO1A", "ERP29", "ESD", "ESF1", "ESYT1", "ETF1", "ETFA", "ETFB", "ETFDH", "EXO1", "EXOC2", "EXOC3", "EXOC5", "EXOC7", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "EZR", "FAF1", "FAF2", "FAH", "FAM129B", "FAM162A", "FAM192A", "FAM208A", "FAM213A", "FAM49B", "FAM8A1", "FAM98B", "FANCI", "FAR1", "FARSA", "FARSB", "FASN", "FBL", "FBXO22", "FBXO7", "FCGRT", "FDFT1", "FDPS", "FECH", "FEN1", "FGFR1OP", "FH", "FHOD1", "FIP1L1", "FIS1", "FKBP10", "FKBP14", "FKBP1A", "FKBP3", "FKBP4", "FKBP5", "FKBP7", "FKBP8", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FMR1", "FN3KRP", "FNTB", "FOXRED1", "FRG1", "FSCN1", "FTO", "FTSJ3", "FUBP1", "FUBP3", "FUCA1", "FUCA2", "FUNDC2", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GADD45GIP1", "GAK", "GALK1", "GALM", "GALNT1", "GALNT2", "GALNT7", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GBA", "GBF1", "GCAT", "GCDH", "GCFC2", "GCLC", "GCLM", "GCN1", "GDI1", "GDI2", "GDPD1", "GEMIN4", "GEMIN5", "GET4", "GFM1", "GFPT1", "GGCT", "GGCX", "GGH", "GGNBP2", "GHITM", "GIGYF2", "GINS3", "GINS4", "GLA", "GLB1", "GLDC", "GLG1", "GLMN", "GLO1", "GLRX", "GLRX3", "GLRX5", "GLS", "GLUD1", "GLYR1", "GM2A", "GMFB", "GMPPB", "GMPS", "GNA13", "GNAI1", "GNAI2", "GNAI3", "GNL1", "GNL2", "GNL3", "GNL3L", "GNPAT", "GNPDA1", "GNS", "GOLGA3", "GOLGB1", "GOLT1B", "GOPC", "GORASP2", "GOT1", "GOT2", "GPAM", "GPATCH4", "GPD2", "GPI", "GPKOW", "GPR107", "GPR108", "GPS1", "GRB2", "GRHPR", "GRIPAP1", "GRPEL1", "GRSF1", "GRWD1", "GSK3B", "GSPT1", "GSR", "GSS", "GSTK1", "GSTM3", "GSTO1", "GSTZ1", "GTF2I", "GTF3C1", "GTF3C2", "GTF3C3", "GTF3C4", "GTPBP1", "GTPBP10", "GTPBP3", "GTPBP4", "GUF1", "GUSB", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACD3", "HACL1", "HADH", "HADHA", "HADHB", "HAT1", "HAUS3", "HAUS5", "HAUS8", "HBS1L", "HCCS", "HCFC1", "HDAC2", "HDGF", "HDGFL2", "HDHD2", "HDHD5", "HDLBP", "HEATR1", "HEATR3", "HEBP1", "HEBP2", "HECTD1", "HECTD3", "HELLS", "HEXA", "HEXB", "HIBADH", "HIBCH", "HIF1AN", "HIGD2A", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HLTF", "HM13", "HMBS", "HMCES", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMGCS1", "HMGN2", "HMOX1", "HMOX2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPLL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HP1BP3", "HPF1", "HPRT1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA13", "HSPA14", "HSPA1B", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPB1", "HSPBP1", "HSPD1", "HSPE1", "HSPH1", "HTATIP2", "HUWE1", "HYOU1", "IARS", "IARS2", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDI1", "IFT27", "IGBP1", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IK", "IKBIP", "ILF2", "ILF3", "ILKAP", "ILVBL", "IMMT", "IMP4", "IMPACT", "IMPDH1", "IMPDH2", "INA", "INCENP", "INTS11", "INTS14", "INTS7", "INTS9", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IRF2BPL", "IRS4", "ISCU", "IST1", "ISYNA1", "ITGB1", "ITM2C", "ITPA", "IVD", "JUP", "KARS", "KCTD12", "KCTD5", "KDELC2", "KDELR1", "KDM1A", "KDM1B", "KDM3B", "KDSR", "KHDRBS1", "KHSRP", "KIAA0368", "KIAA0391", "KIF11", "KIF15", "KIF18B", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF4A", "KIF5B", "KIF7", "KIFBP", "KIFC1", "KLC1", "KMT2A", "KNTC1", "KPNA1", "KPNA2", "KPNA3", "KPNB1", "KRI1", "KRR1", "KTN1", "LAMP1", "LAMTOR1", "LANCL2", "LAP3", "LARP1", "LARP4", "LARP4B", "LARS", "LARS2", "LAS1L", "LASP1", "LBR", "LCLAT1", "LDAH", "LDHA", "LDHB", "LEMD2", "LEMD3", "LETM1", "LGALS3", "LGALS3BP", "LGMN", "LIG1", "LIG3", "LIMA1", "LIPA", "LLGL1", "LMAN1", "LMAN2", "LMNA", "LMNB1", "LNPEP", "LONP1", "LPCAT1", "LPCAT3", "LPGAT1", "LRBA", "LRPPRC", "LRRC40", "LRRC47", "LRRC59", "LRWD1", "LSM14B", "LSM2", "LSM6", "LSM7", "LSS", "LTA4H", "LTN1", "LTV1", "LUC7L2", "LUC7L3", "LYAR", "LYPLA1", "M6PR", "MACF1", "MAD2L1", "MAGED2", "MAN2A1", "MAN2B1", "MANBA", "MANF", "MAP1B", "MAP1S", "MAP2K1", "MAP4", "MAPK1", "MAPRE1", "MAPRE2", "MARC1", "MARCKS", "MARS", "MAT2A", "MAT2B", "MATR3", "MAVS", "MBD3", "MBOAT7", "MCAT", "MCCC1", "MCCC2", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCMBP", "MCU", "MDC1", "MDH1", "MDH2", "MDN1", "ME1", "MECP2", "MED1", "MED21", "MED23", "MED24", "MED25", "MED4", "MFN2", "MFSD10", "MFSD3", "MFSD5", "MGEA5", "MGST2", "MGST3", "MIA2", "MICU1", "MID1", "MIF", "MINDY3", "MINPP1", "MIPEP", "MKI67", "MKRN2", "MLEC", "MMGT1", "MMS19", "MOGS", "MORF4L1", "MORF4L2", "MOSPD2", "MOV10", "MPC2", "MPHOSPH10", "MPHOSPH6", "MPI", "MPP6", "MPRIP", "MPST", "MPV17L2", "MRE11", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL14", "MRPL15", "MRPL19", "MRPL28", "MRPL3", "MRPL37", "MRPL44", "MRPL47", "MRPL9", "MRPS11", "MRPS2", "MRPS27", "MRPS28", "MRPS30", "MRPS33", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRTO4", "MSH2", "MSH3", "MSH6", "MSI2", "MSN", "MSTO1", "MTA1", "MTA2", "MTAP", "MTBP", "MTCH1", "MTCH2", "MTDH", "MTHFD1", "MTHFD1L", "MTHFD2", "MTMR2", "MTMR6", "MTOR", "MTPAP", "MTPN", "MTR", "MTX1", "MTX2", "MVK", "MYBBP1A", "MYCBP", "MYDGF", "MYG1", "MYH10", "MYH14", "MYH9", "MYL6", "MYO1B", "MYO1C", "MYO1D", "MYO6", "NAA15", "NAA25", "NAA40", "NAA50", "NAE1", "NAF1", "NAGLU", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NAPG", "NARS", "NASP", "NAT10", "NAXE", "NBN", "NCAPD2", "NCAPG", "NCAPH", "NCBP1", "NCDN", "NCKAP1", "NCKIPSD", "NCL", "NCLN", "NCOA5", "NCSTN", "NDC1", "NDRG3", "NDUFA10", "NDUFA3", "NDUFA4", "NDUFA5", "NDUFA7", "NDUFA9", "NDUFAF4", "NDUFAF7", "NDUFB10", "NDUFB3", "NDUFB4", "NDUFB5", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS6", "NDUFS7", "NDUFV1", "NDUFV2", "NECAP1", "NECAP2", "NEFL", "NEFM", "NEK9", "NELFA", "NELFB", "NELFCD", "NELFE", "NEMF", "NENF", "NES", "NFU1", "NHP2", "NIFK", "NIPBL", "NKRF", "NLE1", "NLN", "NMD3", "NME1", "NME6", "NME7", "NMT1", "NNT", "NOB1", "NOC2L", "NOC3L", "NOC4L", "NOL10", "NOL11", "NOL6", "NOL9", "NOLC1", "NOM1", "NONO", "NOP14", "NOP2", "NOP53", "NOP56", "NOP58", "NOSIP", "NPC1", "NPC2", "NPEPPS", "NPLOC4", "NPM1", "NRDC", "NRP1", "NSA2", "NSD2", "NSDHL", "NSF", "NSFL1C", "NSUN2", "NSUN5", "NT5C2", "NT5C3B", "NT5DC1", "NT5DC2", "NTHL1", "NTMT1", "NUB1", "NUBP2", "NUCB1", "NUCB2", "NUCKS1", "NUDC", "NUDCD2", "NUDT1", "NUDT12", "NUDT21", "NUDT5", "NUF2", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP160", "NUP188", "NUP205", "NUP210", "NUP214", "NUP37", "NUP43", "NUP50", "NUP54", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NUPL2", "NVL", "NXF1", "NXN", "OAT", "OCIAD1", "OCLN", "OCRL", "OGDH", "OGT", "OLA1", "OPA1", "OPA3", "OSBP", "OSBPL8", "OSBPL9", "OSGEP", "OTUB1", "OTULIN", "OXA1L", "OXSR1", "P3H1", "P3H4", "P4HA1", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PAF1", "PAFAH1B1", "PAFAH1B2", "PAFAH1B3", "PAICS", "PAK1", "PAK1IP1", "PAK2", "PANK4", "PAPOLA", "PAPSS1", "PARK7", "PARN", "PARP1", "PATL1", "PBK", "PBRM1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCK2", "PCLAF", "PCM1", "PCMT1", "PCNA", "PCNP", "PCYOX1", "PDCD11", "PDCD4", "PDCD5", "PDCD6", "PDCD6IP", "PDCL3", "PDE12", "PDE6D", "PDHA1", "PDHB", "PDIA3", "PDIA4", "PDIA6", "PDK1", "PDK3", "PDLIM1", "PDLIM3", "PDLIM5", "PDLIM7", "PDRG1", "PDS5A", "PDS5B", "PDXDC1", "PDXK", "PEBP1", "PECR", "PEF1", "PELO", "PELP1", "PEPD", "PES1", "PEX14", "PEX19", "PFAS", "PFDN2", "PFDN4", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGGT1B", "PGK1", "PGLS", "PGM1", "PGM2", "PGM3", "PGP", "PGRMC1", "PGRMC2", "PHB", "PHB2", "PHF5A", "PHF6", "PHF8", "PHGDH", "PHIP", "PHKA1", "PICALM", "PIGT", "PIH1D1", "PIK3C2A", "PIK3R4", "PIN1", "PIN4", "PIP4K2C", "PIR", "PISD", "PITHD1", "PITPNB", "PITRM1", "PKM", "PKMYT1", "PKN2", "PLA2G15", "PLAA", "PLBD2", "PLCG1", "PLD3", "PLD6", "PLEC", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLRG1", "PLS3", "PM20D2", "PMPCA", "PMPCB", "PNN", "PNP", "PNPT1", "PODXL", "POGZ", "POLA1", "POLA2", "POLD1", "POLD2", "POLD3", "POLDIP2", "POLDIP3", "POLE", "POLE3", "POLE4", "POLR1A", "POLR1B", "POLR1E", "POLR2A", "POLR2G", "POLR3A", "POLR3C", "POLRMT", "PON2", "POP1", "POR", "PPA2", "PPAN", "PPAT", "PPFIA1", "PPHLN1", "PPIB", "PPID", "PPIF", "PPIG", "PPIH", "PPIL4", "PPM1G", "PPME1", "PPP1CA", "PPP1CB", "PPP1R10", "PPP1R7", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP4C", "PPP4R1", "PPP5C", "PPP6C", "PPT1", "PPT2", "PQBP1", "PRAF2", "PRCC", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PREP", "PREPL", "PRIM1", "PRIM2", "PRKAG1", "PRKAR1A", "PRKAR2A", "PRKCD", "PRKCSH", "PRKDC", "PRKRA", "PRMT1", "PRMT3", "PRMT5", "PRMT9", "PRPF19", "PRPF3", "PRPF31", "PRPF38B", "PRPF39", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPS1", "PRPSAP1", "PRPSAP2", "PRRC1", "PRRC2C", "PSAP", "PSAT1", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD6", "PSMD7", "PSMD8", "PSME1", "PSME2", "PSME3", "PSME4", "PSMF1", "PSMG1", "PSMG2", "PSPC1", "PTBP1", "PTBP2", "PTCD1", "PTCD3", "PTDSS1", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK7", "PTPA", "PTPN1", "PTPN11", "PTRH2", "PUF60", "PUM3", "PURA", "PUS1", "PUS7", "PWP1", "PWP2", "PXMP2", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QDPR", "QKI", "QSOX2", "RAB10", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB21", "RAB23", "RAB24", "RAB2A", "RAB35", "RAB3GAP2", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RAB8A", "RABEPK", "RABGAP1", "RABGGTA", "RAC1", "RACGAP1", "RACK1", "RAD21", "RAD23A", "RAD23B", "RAD50", "RAE1", "RAI14", "RALA", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP9", "RANGAP1", "RANGRF", "RAP2B", "RAPGEF2", "RARS", "RARS2", "RAVER1", "RB1", "RBBP4", "RBBP6", "RBBP7", "RBM10", "RBM12", "RBM12B", "RBM14", "RBM17", "RBM19", "RBM22", "RBM25", "RBM26", "RBM27", "RBM28", "RBM3", "RBM39", "RBM4", "RBM5", "RBM8A", "RBMX", "RCC1", "RCC2", "RCL1", "RCN1", "RCOR1", "RDH11", "RDH13", "RDX", "RECQL", "REEP4", "REEP5", "RELA", "REPS1", "RER1", "RETSAT", "REXO4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RHEB", "RHOT1", "RHOT2", "RIDA", "RIF1", "RINT1", "RIOK2", "RIOX1", "RMC1", "RMDN3", "RNASEH2A", "RNASET2", "RNF2", "RNF40", "RNH1", "RNPEP", "ROCK1", "ROCK2", "RPA1", "RPA2", "RPF2", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPN1", "RPN2", "RPP30", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RRBP1", "RRM1", "RRM2", "RRP1", "RRP12", "RRP15", "RRP1B", "RRP8", "RRS1", "RSF1", "RSL1D1", "RSL24D1", "RSU1", "RTCB", "RTFDC1", "RTN3", "RTN4", "RTRAF", "RUFY1", "RUVBL1", "RUVBL2", "RWDD1", "S100A10", "S100A11", "S100A13", "SACM1L", "SAE1", "SAFB", "SAFB2", "SAMHD1", "SAMM50", "SAP130", "SAP18", "SAP30BP", "SAR1A", "SARNP", "SARS", "SARS2", "SART1", "SART3", "SASS6", "SBDS", "SC5D", "SCAMP2", "SCAMP3", "SCARB1", "SCARB2", "SCCPDH", "SCD", "SCFD1", "SCML2", "SCO1", "SCO2", "SCP2", "SCPEP1", "SCRIB", "SCRN1", "SDCBP", "SDE2", "SDF4", "SDHA", "SDHB", "SEC11A", "SEC16A", "SEC22B", "SEC23A", "SEC23IP", "SEC24A", "SEC24B", "SEC24C", "SEC24D", "SEC31A", "SEC61A1", "SEC61B", "SEC61G", "SEC62", "SEC63", "SEH1L", "SEL1L", "SENP3", "SEPHS1", "SEPT2", "SEPT7", "SEPT9", "SERBP1", "SERPINB6", "SERPINH1", "SET", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFSWAP", "SFXN1", "SFXN2", "SFXN4", "SGPL1", "SGTA", "SH3GL1", "SH3GLB1", "SH3PXD2B", "SHCBP1", "SHMT1", "SHMT2", "SHOC2", "SIGMAR1", "SIL1", "SIN3A", "SKIV2L", "SKIV2L2", "SKP1", "SKP2", "SLC12A2", "SLC12A9", "SLC16A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A17", "SLC25A19", "SLC25A20", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A4", "SLC25A42", "SLC25A44", "SLC25A5", "SLC25A6", "SLC27A2", "SLC27A4", "SLC29A1", "SLC30A5", "SLC35A4", "SLC35B2", "SLC35F1", "SLC35F2", "SLC38A2", "SLC3A2", "SLC4A7", "SLC9A3R1", "SLFN11", "SLIRP", "SLIT2", "SLK", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC6", "SMCHD1", "SMN1*", "SMNDC1", "SMPD4", "SMU1", "SMYD3", "SND1", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPC", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNW1", "SNX1", "SNX2", "SNX27", "SNX3", "SNX5", "SNX6", "SNX9", "SOD2", "SON", "SORT1", "SPAG9", "SPART", "SPATA5", "SPC25", "SPCS2", "SPEN", "SPNS1", "SPPL2A", "SPR", "SPTAN1", "SPTBN1", "SPTBN2", "SPTLC1", "SPTLC2", "SQLE", "SQSTM1", "SRCAP", "SREK1", "SRI", "SRM", "SRP14", "SRP54", "SRP68", "SRP72", "SRP9", "SRPK1", "SRPRA", "SRPRB", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF2", "SRSF3", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSNA1", "SSR1", "SSRP1", "STAG2", "STAM", "STAMBP", "STARD3", "STARD3NL", "STAT1", "STAT3", "STAU1", "STAU2", "STIP1", "STMN1", "STOM", "STOML2", "STRAP", "STRBP", "STT3A", "STT3B", "STUB1", "STX18", "STX4", "STX5", "STX7", "STX8", "STXBP3", "STXBP4", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGP2", "SUGT1", "SUN1", "SUPT16H", "SUPT5H", "SUPT6H", "SUPV3L1", "SURF4", "SURF6", "SUZ12", "SYAP1", "SYMPK", "SYNCRIP", "SYNE2", "SYNGR2", "SYS1", "TACC3", "TACO1", "TAF15", "TAF6L", "TAGLN2", "TALDO1", "TAMM41", "TARDBP", "TARS", "TARS2", "TBC1D13", "TBC1D15", "TBC1D4", "TBC1D9B", "TBCA", "TBCD", "TBCE", "TBL2", "TBL3", "TBRG4", "TCEA1", "TCERG1", "TCOF1", "TCP1", "TDP2", "TDRKH", "TECR", "TELO2", "TERF2IP", "TEX264", "TFAM", "TFCP2", "TFG", "TFRC", "THADA", "THOC1", "THOC2", "THOC3", "THOC6", "THOP1", "THRAP3", "THUMPD1", "THUMPD3", "TIAL1", "TIGAR", "TIMM13", "TIMM17A", "TIMM17B", "TIMM23", "TIMM44", "TIMM50", "TIMM8A", "TIMM8B", "TIPRL", "TJP1", "TK1", "TKT", "TLCD1", "TLN1", "TM9SF3", "TM9SF4", "TMCO1", "TMED10", "TMED2", "TMED5", "TMED7", "TMED9", "TMEM109", "TMEM11", "TMEM126A", "TMEM14C", "TMEM199", "TMEM214", "TMEM230", "TMEM259", "TMEM33", "TMEM43", "TMEM65", "TMEM97", "TMOD3", "TMSB4X", "TMTC3", "TMX1", "TMX2", "TNPO1", "TNPO3", "TOE1", "TOLLIP", "TOM1", "TOMM20", "TOMM22", "TOMM34", "TOMM40", "TOMM5", "TOMM70", "TOP1", "TOP2A", "TOP2B", "TOR1AIP1", "TOR1AIP2", "TP53", "TP53BP2", "TPD52", "TPD52L2", "TPI1", "TPM1", "TPM3", "TPM4", "TPP1", "TPP2", "TPR", "TPT1", "TPX2", "TRA2A", "TRA2B", "TRAF2", "TRAM1", "TRAP1", "TRAPPC11", "TRAPPC3", "TRAPPC4", "TRAPPC5", "TRIM21", "TRIM25", "TRIM28", "TRIM33", "TRIO", "TRIP12", "TRIP13", "TRMT10C", "TRMT1L", "TRMT6", "TROVE2", "TRUB1", "TSFM", "TSG101", "TSN", "TSNAX", "TSPAN6", "TSPO", "TSR1", "TTC1", "TTC19", "TTC26", "TTC37", "TTC4", "TTK", "TTLL12", "TTYH3", "TUBB", "TUBB2A", "TUBB2B", "TUBB4A", "TUBB4B", "TUBB6", "TUBGCP2", "TUBGCP3", "TUFM", "TWF1", "TWF2", "TXLNA", "TXLNG", "TXNDC12", "TXNDC17", "TXNDC5", "TXNDC9", "TXNRD1", "TYMS", "U2AF2", "U2SURP", "UAP1", "UBA1", "UBA2", "UBA3", "UBA6", "UBAP2L", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2O", "UBE2Q1", "UBE2S", "UBE3C", "UBE4A", "UBR2", "UBR4", "UBR5", "UBR7", "UBTF", "UBXN7", "UCHL5", "UCK2", "UFC1", "UFD1", "UFL1", "UGCG", "UGDH", "UGGT1", "UGP2", "UHRF1", "UMPS", "UNC119B", "UNC45A", "UPF1", "UQCC2", "UQCR10", "UQCRC1", "UQCRC2", "UQCRQ", "URB1", "UROD", "USO1", "USP10", "USP11", "USP14", "USP24", "USP28", "USP34", "USP39", "USP47", "USP48", "USP5", "USP7", "USP8", "USP9X", "UTP14A", "UTP15", "UTP18", "UTP20", "UTP4", "UTP6", "UTRN", "VAMP7", "VANGL1", "VAPA", "VAPB", "VARS1", "VAT1", "VBP1", "VCL", "VCP", "VDAC1", "VDAC2", "VDAC3", "VIM", "VKORC1L1", "VMP1", "VPS16", "VPS18", "VPS26A", "VPS29", "VPS33B", "VPS35", "VPS4A", "VPS4B", "VPS51", "VPS53", "VRK1", "WAPL", "WARS", "WBP11", "WDHD1", "WDR1", "WDR12", "WDR18", "WDR3", "WDR33", "WDR36", "WDR4", "WDR41", "WDR43", "WDR5", "WDR6", "WDR61", "WDR75", "WDR77", "WDR91", "WFS1", "WIPI2", "WIZ", "WLS", "WTAP", "XAB2", "XPNPEP1", "XPNPEP3", "XPO1", "XPO4", "XPO5", "XPO7", "XPOT", "XRCC5", "XRCC6", "XRN2", "YARS", "YARS2", "YBX1", "YKT6", "YLPM1", "YME1L1", "YRDC", "YTHDC1", "YTHDC2", "YTHDF2", "YTHDF3", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2", "ZC3H11A", "ZC3H14", "ZC3H15", "ZC3H18", "ZC3H4", "ZC3HAV1", "ZCCHC11", "ZCCHC3", "ZCCHC8", "ZFYVE16", "ZMPSTE24", "ZMYM4", "ZNF318", "ZNF326", "ZNF638", "ZPR1", "ZW10", "ZYX"], "leading_proteins": ["AASDHPPT", "ABCB1", "ABCD3", "ABHD10", "ABHD12", "ABI1", "ACAT2", "ACOT7", "ACOT9", "ACOX1", "ACP2", "ACP6", "ACSL3", "ADI1", "ADK", "ADSS", "AIFM1", "AIP", "AKAP1", "AKT2", "ALDH3A2", "ALDH6A1", "ALDH9A1", "ALG1", "ALG12", "AMOT", "ANKLE2", "ANLN", "ANXA1", "ANXA11", "APLP2", "APOL2", "APOO", "APOOL", "APP", "ARF4", "ARFIP2", "ARHGEF2", "ARID1A", "ARL1", "ARL6IP1", "ARL6IP5", "ARMC10", "ARV1", "ASAH1", "ASNA1", "ATAD3A", "ATP13A1", "ATP1A1", "ATP1B1", "ATP2A2", "ATP2C1", "ATP5F1", "ATP5L", "ATP6AP1", "ATP6AP2", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP7B", "AURKA", "B4GAT1", "BAG5", "BAG6", "BAIAP2", "BCAP31", "BCS1L", "BICD2", "BSG", "C12orf73", "C19orf70", "C1QBP", "CALM3", "CAMK1", "CANX", "CARM1", "CCDC47", "CCNB1", "CCNB2", "CDC40", "CDK4", "CERS2", "CETN2", "CHCHD3", "CHKA", "CHORDC1", "CHST14", "CHUK", "CIRBP", "CISD2", "CLCC1", "CLCN3", "CLCN7", "CLN5", "CLPB", "CLPP", "CLPTM1", "CLUH", "CNNM4", "CNOT4", "COL4A3BP", "COLEC12", "COMT", "COQ3", "COQ9", "COX2", "COX5A", "COX7A2", "CPD", "CPOX", "CPT2", "CRK", "CRKL", "CRTAP", "CSGALNACT2", "CSNK1A1", "CTBS", "CTNNB1", "CTSA", "CTSB", "CTSC", "CTU2", "CUL4B", "CXADR", "CYB5B", "CYB5R1", "CYFIP1", "CYP51A1", "DAZAP1", "DCAKD", "DCTN2", "DCTPP1", "DDRGK1", "DDX17", "DDX39B", "DDX3X", "DDX5", "DERL1", "DHCR24", "DHCR7", "DHFR", "DHX36", "DHX9", "DIABLO", "DIAPH2", "DKC1", "DNAJA1", "DNAJA3", "DNAJC10", "DNAJC3", "DNASE2", "DNM1L", "DNM2", "DNPH1", "DR1", "DSC3", "DSG2", "DUSP9", 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0.1887666227175413 6.920437110961116 4.902057024259538 2.8947011026985514 0.298290072492813 2.511427758577322e-24 5.744653946719455e-20 3.378346448244335e-26 6.983537800924812e-27 3.4384387752604765e-21 +Azurophil granule 27 67 3.830080810153543 0.0001281011836387 20.46359223300971 67.00485436893204 0.4795255752980384 0.3097891700346699 6.177875864944045 5.290582926033595 2.1760997104513735 0.3628132485163926 9.798114364634597e-18 4.70024796631574e-12 4.922581875660878e-16 1.7206787852464895e-18 2.5474280556988478e-17 +Lysosomal lumen 26 37 3.810561220336466 0.0001386516701822 18.075242718446603 34.54368932038835 0.7848519845050315 0.1014568164283454 6.206531846566726 3.2976210873168883 3.038689298289951 0.2012423645269794 4.188104427469584e-26 5.8435039624796655e-22 5.8826350669194326e-27 1.5890221643180829e-29 2.893641387285107e-23 +Endocytic vesicle 24 73 3.607962308200756 0.00030861130956 19.521844660194176 83.27669902912622 0.428513908443532 0.5353120905813061 7.647069906220736 7.607555057832984 1.324058617895936 0.3761698531660883 8.006269053943422e-06 0.07440901727418 2.497075813619459e-05 9.005442693133766e-06 5.494231888453218e-07 +Intrinsic component of organelle membrane 53 103 3.012383789322376 0.0025920466015436 52.51699029126213 129.34223300970874 2.0732064315361294 0.2796588394070637 24.692225942786415 15.820346456508432 2.8130846896968285 0.39829365000917 1.6136244142934458e-06 0.055897849719298 0.0006101441294703 3.753799402963599e-06 4.4116886608803005e-10 +Early endosome 26 79 2.970316886277697 0.0029749270192125 24.66504854368932 96.93203883495146 0.530758374709677 0.5743319290889299 8.086272783051246 14.025470683081796 1.1449007118883376 0.3721207721610414 0.0026650335887161 0.0459167590911818 0.001524970273296 0.0001694330287109 0.0001012325846724 +Azurophil granule membrane 9 20 2.9067780543705632 0.0036517219289644 7.856796116504855 21.259708737864077 1.0757479237162697 0.2373572682944545 3.393508570011604 2.63895903142419 1.639408148995933 0.2881313440808664 1.56299887485961e-08 6.62304209379958e-05 7.426975816356085e-05 1.0990774673212225e-07 1.2605741951286083e-06 +Secretory granule membrane 22 61 2.8888509998416168 0.0038665223794986 19.699029126213592 69.8495145631068 0.9295860214656708 0.3887665887416008 7.284889203542463 7.49087955205396 1.5950364553562375 0.3903287060113383 3.454444990589351e-07 0.0016900813978939 5.809670081265907e-05 4.0144711489803103e-10 4.2240131329520247e-08 +Endocytic vesicle membrane 14 36 2.8708518786590544 0.004093672961267 11.41019417475728 40.75728155339806 0.6528171904926832 0.3529092384633215 4.825015011915381 4.780047567333447 1.5638167276319088 0.3380752375601685 5.303196373201988e-06 0.1023626206743454 0.0001027523849246 3.2232352245459235e-06 0.0001030588160392 +Cell surface 21 60 2.848277425563378 0.0043956588186393 21.233009708737864 77.5995145631068 0.4772545566224628 0.498248600191797 7.455308766626032 8.832436895439663 1.3320096182828691 0.3812427248674431 0.0061248652570707 0.017114113982754 0.0032283009981787 0.0002325775171701 0.0323959192655305 +Transport vesicle 19 78 2.832865284407467 0.004613282352442 26.046116504854368 92.34708737864078 0.9512017428916244 0.4458616213657612 9.46815354334768 9.09007867686459 1.424803887648301 0.3967491654773343 0.0046898340709081 0.0361650112586197 0.0035755565576522 0.0006071024693254 0.0080874350268743 +External side of plasma membrane 9 19 2.825893831198296 0.0047148888483654 6.856796116504855 22.03640776699029 0.7617836494895279 0.3205100812766187 3.0547396608098576 3.343757364022431 1.3549821177336052 0.303342613906597 0.0043859663521492 0.0142331659478869 0.0189133156354044 0.0010563163696106 0.0324582454729455 +Coated vesicle 13 77 2.806099655693694 0.005014518120868 21.15776699029126 89.28398058252426 0.7996411773181966 0.4463095457932411 7.252509633536616 8.542551157088123 1.3406722753228342 0.3892656029628454 0.0001611652002031 0.0026716839117735 0.000130057928254 0.0001086888022113 0.0179893395367909 +Phagocytic vesicle membrane 7 21 2.79536823990196 0.0051840628768375 7.512135922330097 23.83009708737864 0.5348434256443761 0.4468744105904624 3.681144332021715 3.0024693704800938 1.1652764437248655 0.3385441964418395 0.0018641413197488 1.0 0.0207328276809773 0.0001028265848382 0.0025023010526467 +Intrinsic component of plasma membrane 39 61 2.7786696056490388 0.0054582010466832 29.711165048543688 79.49271844660194 0.9914207279546418 0.2992612012372248 13.467745416506318 12.62980929789956 2.1277799030157807 0.3627370007757806 0.0181869997168924 0.0235768975817832 0.0352673887355978 0.000955567230279 0.0001515743535632 +Side of membrane 16 58 2.6923661906174674 0.0070946998773002 17.526699029126213 71.19660194174757 0.4235531336200628 0.5236659753791312 6.9409272887607125 8.635706418493163 1.198097658489356 0.36822581052137 0.0103405593253533 0.0311941867041664 0.0026808363995263 0.0010691631424798 0.03346115114565 +Golgi membrane 30 110 2.6674218497454736 0.0076435663446225 41.28398058252427 131.19174757281553 1.6327747521284677 0.3511039607499193 15.277988344159814 17.44963987873233 1.926180921267262 0.4033858283713009 0.0004365205764998 0.1463513896823768 0.0002029735908402 0.00064100143229 0.001442027294315 +Cis golgi network 2 11 2.654667004254238 0.0079386732447439 5.446601941747573 14.91747572815534 1.304763677188147 0.2415633778835601 2.9087352716231463 3.2280604409731746 1.23405443481851 0.2890539664507128 0.0187034961823313 1.0 0.0061250241039257 0.0678108138951911 0.2925706278956133 +Vacuolar membrane 33 108 2.6311799135699685 0.0085088977877392 31.91504854368932 121.20631067961163 0.8693310080509177 0.3422944242486927 10.598363436017626 13.850227259030053 1.9844114292962869 0.3837860427998523 8.44345888934121e-11 3.5494586327475044e-06 2.614949352201343e-09 2.7120767887146928e-11 1.3918244676377452e-08 +Azurophil granule lumen 13 44 2.6259501595083097 0.0086407468548477 12.118932038834952 41.25728155339806 -0.033426136567579 0.3776020138210581 4.31782609196223 3.0753988435553 1.7699755963815147 0.3570217435028845 1.337782299898019e-09 4.959713459985912e-07 1.4856415726341172e-11 1.6472742946342745e-11 5.420821390418807e-10 +Outer membrane 22 71 2.592687362029273 0.0095229294469572 28.936893203883496 87.79611650485437 1.4859238244628277 0.3236686433663402 11.632349354832256 8.24751710010496 1.9336855473946637 0.38878066573106 0.0048284506266684 0.0559390979061329 0.0301417198148606 3.26585493405961e-05 5.75786119920344e-07 +Lumenal side of membrane 4 10 2.580093104137918 0.0098773681057635 3.686893203883495 9.509708737864075 0.6270696996832885 0.3351332813726532 1.8490414883089543 0.9791034697552432 1.2332692274886168 0.3003490996154719 0.0037696679890287 0.1006582454154426 0.0011613234829685 0.0001505310959671 0.0034687949642114 +Vacuole 64 197 2.5674349059955337 0.0102454023458555 55.029126213592235 212.35679611650485 0.7895788564169173 0.4204713883128338 16.092847298969616 21.031446114270427 2.221429361906059 0.4148180554719883 8.672870883913632e-24 1.2824592108830674e-16 3.792271420073768e-25 2.630081322467196e-27 6.068939066236079e-20 +Proton transporting v type atpase complex 4 13 2.506819542860251 0.0121822888908642 3.1723300970873787 11.17233009708738 1.083137374920517 0.3054753623634815 1.8106779848505148 1.1913569842207026 0.9186852151104662 0.2868810804648729 8.757696349628895e-05 1.0 0.1515272625734178 3.906142953800441e-05 9.825976589410204e-05 +Intrinsic component of endoplasmic reticulum membrane 15 41 2.486087319292753 0.0129156270611126 21.439320388349515 53.03155339805825 1.5445183869163015 0.2945609219212759 9.936629672422429 6.151523176643304 2.1054078800196185 0.3580268322643601 8.725631092041593e-05 0.4570575797650001 0.0072395357132445 5.2829178733530186e-05 0.0001164269137798 +Endoplasmic reticulum lumen 17 51 2.442367660615081 0.0145912782262382 18.07766990291262 59.737864077669904 0.9896277047863468 0.3946249358858228 7.513340007333169 6.273245958458151 1.4320597420402308 0.3846324865730224 0.0115244862367003 0.0473127294122767 0.0232854211622899 0.0002318296970005 0.0001908123500498 +Intrinsic component of golgi membrane 4 10 2.4185394519982184 0.0155829556539401 4.655339805825243 10.08495145631068 1.3178763872097854 0.2129685736028588 2.6046347098798024 1.9780511021437377 1.2704958978874823 0.2699640456705705 0.0003323540822832 1.0 0.0614247268920475 0.0032788281256578 0.003703553796165 +Pigment granule 13 59 2.403490504824391 0.016239388739546 17.058252427184467 60.37135922330097 0.3452760243889364 0.5728855837677844 7.454164461546019 2.3255555964379067 1.200064167427868 0.3798846852248331 4.627436023761229e-05 0.0693781645438786 0.0017072304004418 2.262222867872229e-07 1.1857268519954143e-06 +Clathrin coated endocytic vesicle membrane 4 12 2.360991145829448 0.0182261657699032 3.796116504854369 13.682038834951456 0.0573666642471241 0.400612365903674 2.3816010903207343 1.646817383208435 1.3652035545006669 0.3297171871883064 0.0139683468541165 0.0121686135974036 0.0443091130960601 0.0097601039903573 0.0255449311307142 +Recycling endosome 13 31 2.3458153672832904 0.0189855095956186 11.66504854368932 38.48300970873787 0.3314123370484901 0.5655153978404952 4.733627044629046 5.712973030267684 1.060328776827888 0.3489425897551162 0.0598685238651644 0.1536755608549872 0.0508615398673609 0.002737701830344 0.0044234194628661 +Endoplasmic reticulum golgi intermediate compartment membrane 6 22 2.317443697641677 0.0204795743009977 10.49271844660194 25.839805825242717 1.5441023898993702 0.2324243418613106 5.505729177420246 3.7718384126099376 1.49831312620529 0.2965572765953523 0.0001363577396877 1.0 0.0978881295505725 0.000338442961232 0.001186229545761 +Blood microparticle 5 17 2.3151781304780603 0.0206031855887343 4.735436893203883 17.08252427184466 0.278306270999014 0.48728609275096 2.8336409309630577 1.4740425350178823 1.0421411126986748 0.31816279579515 0.0227689228838518 0.0172375696548913 0.0614247268920475 0.0032788281256578 0.0149334923888548 +Lumenal side of endoplasmic reticulum membrane 3 8 2.30061906292293 0.021413172565031 3.0776699029126213 7.361650485436893 0.5475818769285827 0.3637002691484017 1.5990854205757892 0.8689828861838115 1.1522443815379428 0.2937666584254462 0.0275018892804849 0.083126337411673 0.0126574737404708 0.0007869115437374 0.0096830476876922 +Exocytic vesicle 8 29 2.292484956942381 0.0218776746184239 12.106796116504857 38.40533980582524 0.7408080162244459 0.4227017753873355 4.952517495270036 4.6543925000719675 1.3317240485888555 0.365166844745196 0.0478613081796197 0.0273793785175047 0.1426674419185315 0.0472591260060401 0.1235971216022149 +Phagocytic vesicle 13 36 2.1726671068381216 0.0298053811566043 11.54126213592233 41.59708737864078 0.3919256884663005 0.5681630099638236 4.854259100699266 4.0100348958770144 0.9938295058309184 0.3509625084864278 0.0032893365301943 0.3837477700868037 0.0155897140308174 0.000693686312984 0.0010334461262557 +Golgi associated vesicle 5 27 2.1555519373077128 0.0311186689627371 6.745145631067961 30.33009708737864 0.696501539533066 0.3869218626415568 3.3093865809086713 3.3403631844705557 1.2881306559419168 0.3350067162782171 0.0030123495455967 0.0041986670986062 0.0004780854780595 0.0059425292278447 0.1106465000297166 +Proteasome core complex beta subunit complex 6 7 2.1343903070752974 0.0328108443682415 3.699029126213592 6.970873786407767 1.6670727234653664 0.1509307531330224 1.4503762582219135 0.1681602725795027 0.9611878160538336 0.233503072382129 0.0002361262018994 1.0 0.0031504918831051 9.327097249989188e-07 1.9890121517705644e-08 +External encapsulating structure 9 27 2.126160224745955 0.033489920724735 8.740291262135923 33.067961165048544 0.2475250746714072 0.5329464629763961 4.007036034183376 4.3711590871852435 1.0928778643562622 0.3321243069645864 0.0994822332743615 0.0473127294122767 0.0056874611143685 0.1163869155655028 0.1968474374822907 +Clathrin coated endocytic vesicle 4 15 2.1222352253561376 0.033817989868079 4.774271844660194 18.74271844660194 -0.0983362729934113 0.4816370533307881 3.136849294900222 2.1033538609603957 1.2416005860349415 0.3436375292109884 0.0272765651043488 0.0196403757049561 0.0693457394610891 0.0230341265569123 0.0651237881613715 +Cytochrome complex 7 12 2.109970019147496 0.0348609383528031 6.021844660194175 16.08495145631068 1.0267019648816196 0.2321293206617183 2.9315837025395948 1.6175814223208935 1.624269406530766 0.2919563386676546 0.0658392940592545 1.0 1.0 0.0322769586697076 0.163813839479234 +Snare complex 4 10 2.06640766637474 0.0387900026637508 6.20873786407767 15.79368932038835 0.8138466711937282 0.3737991711938105 3.1112263618988054 3.010283181947674 1.1802712183474584 0.3261149602927671 1.0 1.0 1.0 0.6524035152067593 0.0554387032447054 +Endoplasmic reticulum golgi intermediate compartment 8 42 2.0526932790000587 0.0401023343029975 14.888349514563108 49.49271844660194 1.4759277407874345 0.3201471070907981 6.47003250199477 5.053350843348441 1.420924643396655 0.3585240832471577 8.520567031419852e-05 0.377722993581858 0.0681614338573012 0.0005983999159821 0.0026681206431513 +Respirasome 14 34 2.0525547676049976 0.0401157782444705 15.08495145631068 43.37378640776699 1.2524823540042158 0.2922262294299136 6.290312072426717 4.489587979561489 1.7783434517583476 0.3462844006183536 0.3505018761083549 1.0 1.0 0.0044585204680354 0.0077918698356329 +Nadh dehydrogenase complex 4 18 2.0502993437586152 0.0403352286003346 7.419902912621359 23.609223300970875 0.690247022635013 0.3818090321561181 3.6908298840900926 3.1049932192976284 1.21822710313397 0.3228613418826432 1.0 1.0 1.0 0.0949405615621671 0.0651237881613715 +Pore complex 3 8 2.007720265900762 0.0446730258429801 3.2111650485436893 8.830097087378642 1.029129610796519 0.2182996080526768 1.893158762220583 0.772882004264421 1.343874754683687 0.2717215815078918 0.0246776823845801 0.0029386578360865 0.0113213926532688 0.0074273483269255 0.0078256896811826 +Recycling endosome membrane 7 18 2.001243504513258 0.0453661547443338 6.888349514563107 22.509708737864077 0.1536767921278238 0.6101735952601732 3.1901182670006487 3.1100218387491214 0.9055004805495972 0.3161343906862945 0.2917665823016794 1.0 0.5119234098565739 0.0089239350034266 0.0091692804635719 +Endosome membrane 31 100 1.9688680399899543 0.0489682464830014 28.436893203883496 125.75485436893204 0.1968108610887141 0.5657595498250074 10.058247741499075 16.477863960688197 1.2734596099850304 0.3756178998455078 3.748016068809889e-05 0.0355718943952394 0.000284664713323 1.8130579488762124e-06 9.481505361415656e-05 diff --git a/msigdb_gocc/metrics.json b/msigdb_gocc/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..5e403e1b319e69df8abc0f8c6e44f965a0fc7d32 --- /dev/null +++ b/msigdb_gocc/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2644, + "annotations_size": 879, + "title": "Average number of proteins per term", + "value": 25.055745164960182 +} \ No newline at end of file diff --git a/msigdb_gocc/paths.json b/msigdb_gocc/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..cd6d20177a1bf123cd332782fd90d86f4ddc85bc --- /dev/null +++ b/msigdb_gocc/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/msigdb_gocc/fragment/C197/C197_val_log2fc"} \ No newline at end of file diff --git a/msigdb_gocc/result.tsv b/msigdb_gocc/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..e71c83007de4dc3539a4c2c6f779d96a82f9c43f --- /dev/null +++ b/msigdb_gocc/result.tsv @@ -0,0 +1,274 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Vacuolar lumen 0.7743169520082808 4.41690832620545 1.0012266819625635e-05 0.0087622126794282 0.0088007825344518 67 Q13510,Q8NHP8,Q9UM22,P07858,O00584,P50897,Q9UMR5,P06280,P07602,Q99538,P15586,Q9BTY2,Q14108,P06865,P16278,O00462,P61916,P11117,P54802,Q8IV08,O14773,P04062,P10619,O00560,Q92820,P04066,P53634,P17900,P10253,P08236,P07686,O00754 32 +Azurophil granule 0.6970352336374644 3.830080810153543 0.0001281011836387 0.1064992930702278 0.0406249393633944 67 O15400,O00584,P06280,P07602,O15260,P15586,Q9BTY2,P06865,Q9NQX7,P16278,O00462,P61916,P27105,P10619,O00560,Q92820,P42785,P04066,P53634,P17900,P10253,P11279,P08236,P51809,P07686,Q92542,O00754 27 +Lysosomal lumen 0.8836534192140371 3.810561220336466 0.0001386516701822 0.114748300278237 0.0406249393633944 37 Q13510,Q8NHP8,Q9UM22,P07858,O00584,P50897,P06280,P07602,Q99538,P15586,Q14108,P06865,P16278,O00462,P61916,P11117,P54802,Q8IV08,O14773,P10619,P04066,P17900,P10253,P08236,P07686,O00754 26 +Endocytic vesicle 0.6199802507473519 3.607962308200756 0.00030861130956 0.2376207991078104 0.067817335275823 73 O15400,Q14108,P11717,P01889,P51790,P04439,P20645,Q93050,O00461,Q9UNK0,Q9H223,P11233,Q06481,Q8WTV0,Q9H4M9,Q16625,P10321,Q5T9L3,Q5KU26,P11279,Q9Y487,P02786,P51809,Q14254 24 +Intrinsic component of organelle membrane 0.5836786074933344 3.0123837893223757 0.0025920466015436 0.897855514800528 0.3198505813356393 103 Q99595,Q8TB61,Q9H3K2,P57088,P17152,Q6ZRP7,Q9Y282,P12235,O43819,P42892,O14925,Q8TCT8,Q13505,O76024,Q9NQC3,P01889,O60830,O14975,P51572,Q15041,Q9NPA0,P04439,Q8N2H4,Q15070,Q14739,O75844,Q00325,Q5XKP0,Q9Y3D6,Q9UBM7,O95470,Q9BUN8,O96008,Q6P4A7,Q9HCU5,P98194,Q6UXV4,Q10471,Q9Y4P3,Q15629,P10321,Q96A33,Q8N6G5,Q5T9L3,Q96NB2,O43505,Q15388,P51149,Q86XL3,Q9BUR5,O15118,O95563,O95140 53 +Early endosome 0.5493462321335998 2.970316886277697 0.0029749270192125 0.9271139663251284 0.3198505813356393 79 Q13510,Q96L92,O15400,P05067,Q92544,P11717,O14786,Q5VW38,P01889,P51790,P04439,Q8IV08,Q9BUN8,Q9UNK0,Q9H223,Q06481,Q9H4M9,Q9UIQ6,Q96A57,P10321,Q5T9L3,Q99523,O75955,P02786,O95630,Q92542 26 +Azurophil granule membrane 0.7640567600829796 2.9067780543705632 0.0036517219289644 0.9598743158526796 0.3198505813356393 20 Q9NQX7,P10253,P11279,O00462,P27105,P07602,O15260,P42785,Q92542 9 +Secretory granule membrane 0.6200909717840819 2.8888509998416168 0.0038665223794986 0.9668018351603512 0.3198505813356393 61 P07602,O15260,P11717,Q9NQX7,P01889,O14975,O75787,O00462,P27105,Q93050,P30519,Q06481,P35613,P42785,P10321,Q8TAD4,P10253,P11279,P61225,O00264,P51809,Q92542 22 +Endocytic vesicle membrane 0.7270196290882239 2.8708518786590544 0.004093672961267 0.9728322292182984 0.3198505813356393 36 P11717,P20645,Q06481,P01889,Q8WTV0,P11279,Q9Y487,P02786,P51809,P04439,P10321,Q93050,Q14108,Q5KU26 14 +Cell surface 0.6207634329485802 2.848277425563378 0.0043956588186393 0.979189570659791 0.3198505813356393 60 P07858,P05067,P08195,P42892,P08183,Q14126,P11717,P01889,O75787,P51790,P04439,P11233,Q8WTV0,P10321,P55899,Q99523,O75955,P11279,O96005,P02786,Q07021 21 +Transport vesicle 0.5338256632551627 2.832865284407467 0.004613282352442 0.9828276999971955 0.3198505813356393 78 O15400,P50897,P05067,O15260,P11717,P01889,O00429,P51790,P04439,Q9UKR5,O00461,P24390,O43760,Q96A57,P10321,Q99523,P11279,P51809,Q92542 19 +External side of plasma membrane 0.7501812621661895 2.8258938311982957 0.0047148888483654 0.984301471224749 0.3198505813356393 19 O75955,P11279,O96005,P07858,O75787,P02786,P51790,P42892,P55899 9 +Coated vesicle 0.5297735715497873 2.806099655693694 0.005014518120868 0.9879519193331197 0.3198505813356393 77 Q99523,P11717,Q5VW38,P01889,Q9Y282,P02786,P24390,Q8N511,P05067,P53634,P42892,P10321,Q14108 13 +Phagocytic vesicle membrane 0.7429880107756548 2.79536823990196 0.0051840628768375 0.9896279811596828 0.3198505813356393 21 Q06481,P01889,P11279,Q9Y487,P04439,P10321,Q93050 7 +Intrinsic component of plasma membrane 0.6064048008243548 2.7786696056490388 0.0054582010466832 0.991859471108086 0.3198505813356393 61 P12235,P17152,Q15375,O43657,P05067,P53985,O60637,Q8N2K0,O14786,P11717,P01889,P55011,P27105,P51790,P04439,Q99808,Q00325,P36551,P16615,O00592,P20645,P35670,Q9UNK0,P05026,Q13308,Q8WTV0,O00560,P35613,Q9UIQ6,P10321,Q8TAD4,P11279,O96005,P02786,O00264,P78310,Q96QD8,O15118,Q92542 39 +Side of membrane 0.6119134272264241 2.6923661906174674 0.0070946998773002 0.9980858249168596 0.3797608242705576 58 O75955,P11279,P01889,P07858,O96005,O75787,P10619,P02786,P51790,P04899,P04439,P10321,P42892,Q8TCT8,P55899,P17900 16 +Golgi membrane 0.5560203206679114 2.6674218497454736 0.0076435663446225 0.998822667286052 0.3797608242705576 110 Q8TB61,Q6ZRP7,Q9Y282,Q9H7Z7,O15260,Q8IZA0,Q14108,P11717,Q10713,P01889,P51790,P04439,Q8N2H4,Q16739,Q8IV08,P35670,O00461,Q10472,P24390,Q92896,P35613,Q15392,P10321,Q8N6G5,O95197,Q5T9L3,O43505,Q8NCH0,Q9BUR5,Q9P2W9 30 +Cis golgi network 0.7997256018120229 2.654667004254238 0.0079386732447439 0.9990935182461546 0.3797608242705576 11 Q9NPR9,O00461 2 +Vacuolar membrane 0.5500447040858686 2.6311799135699685 0.0085088977877392 0.9994531429964298 0.3797608242705576 108 O15400,O75503,P07602,O15260,P42892,Q8TCT8,Q14108,Q9NQX7,O75787,O00462,P27105,P51790,Q8IY95,P11117,Q93050,Q8IV08,Q96GC9,P04062,Q8WTV0,P10619,Q9UIQ6,P42785,Q16625,Q99523,O95772,P10253,P11279,Q9Y487,O75955,Q8N511,P51809,O15118,Q92542 33 +Azurophil granule lumen 0.6637112981132355 2.6259501595083097 0.0086407468548477 0.9995134743413336 0.3797608242705576 44 P16278,O00584,P10619,P61916,P08236,P06280,Q92820,P15586,P07686,P04066,P53634,Q9BTY2,P17900 13 +Outer membrane 0.5242697524386022 2.592687362029273 0.0095229294469572 0.9997775407051632 0.391552550522046 71 P30536,P21796,Q5VT66,Q13505,Q9HCL2,Q8N2A8,P45880,O00429,O43169,Q5XKP0,Q9Y3D6,Q9UBM7,Q9NS69,P50402,Q8N4H5,Q9Y277,O00264,Q99720,Q9BUR5,Q9NQZ5,O95140,Q9NZJ7 22 +Lumenal side of membrane 0.8230836732104719 2.580093104137918 0.0098773681057635 0.9998375872625463 0.391552550522046 10 P10619,Q8TCT8,P01889,P10321 4 +Vacuole 0.6270207499699145 2.5674349059955337 0.0102454023458555 0.99988286222621 0.391552550522046 197 Q8NHP8,Q13510,Q9UM22,O75503,P07858,O00584,P50897,Q9UMR5,P06280,P07602,Q13501,Q99538,P15586,O15260,P42892,Q9BTY2,Q8TCT8,Q14108,Q01459,O00115,P06865,Q9NQX7,P16278,O75787,O00462,P61916,P27105,P51790,Q8IY95,P11117,P54802,Q93050,Q8IV08,O14773,Q96GC9,Q5BJF2,P04062,Q9UHG3,Q8WTV0,P10619,Q8NCC3,O00560,Q9UIQ6,Q92820,P42785,Q16625,Q96A57,P04066,P53634,P17900,Q99523,P38571,O95772,P10253,P11279,Q9Y487,O75955,Q8N511,P08236,Q9NX40,P07686,O15118,Q92542,O00754 64 +Proton transporting v type atpase complex 0.7487746018140456 2.506819542860251 0.0121822888908642 0.999979062985566 0.4283292774027873 13 Q93050,Q8N511,Q15904,Q9Y487 4 +Intrinsic component of endoplasmic reticulum membrane 0.6527917254077592 2.486087319292753 0.0129156270611126 0.9999891004399633 0.4366475456429991 41 Q8TB61,P01889,O14975,Q9Y282,Q15041,P04439,Q9Y4P3,Q86XL3,Q15629,O75844,P10321,Q8TCT8,Q9UBM7,O95470,Q9BUN8 15 +Endoplasmic reticulum lumen 0.6116172723372542 2.442367660615081 0.0145912782262382 0.9999975519671778 0.4750271689208689 51 P13674,Q06481,O14975,O00584,Q9NWM8,O95881,O43681,Q14257,P05067,Q32P28,O43852,Q9Y680,P53634,Q9BTY2,Q02818,O75718,Q9NZ08 17 +Intrinsic component of golgi membrane 0.7891642674226474 2.4185394519982184 0.0155829556539401 0.9999989896997336 0.4758140900686978 10 Q8N2H4,Q8TB61,Q6ZRP7,O43505 4 +Pigment granule 0.5710230752004231 2.403490504824391 0.016239388739546 0.9999994379061128 0.4758140900686978 59 O75955,P11279,P07858,P02786,O00560,P35613,P27105,Q92820,O43852,Q93050,Q92542,O14773,P55209 13 +Clathrin coated endocytic vesicle membrane 0.7312469751073677 2.360991145829448 0.0182261657699032 0.999999904924754 0.5006768190902618 12 P02786,P11717,Q14108,P51809 4 +Endosome lumen 0.9723484848484856 2.3609712738976403 0.0182271424469719 0.9999999050078552 0.5006768190902618 4 Q99538,P07858,P05067 3 +Recycling endosome 0.6542839741002886 2.3458153672832904 0.0189855095956186 0.9999999518389198 0.5057049374105687 31 Q9H223,O15400,P01889,P61225,P02786,P51790,P05067,P04439,Q96A57,P10321,O15127,O14773,Q9UNK0 13 +Endoplasmic reticulum golgi intermediate compartment membrane 0.6595739182661206 2.317443697641677 0.0204795743009977 0.999999987385688 0.5174342894999273 22 Q9Y282,P24390,Q8N511,O15260,P53634,Q15904 6 +Blood microparticle 0.6710761065879107 2.3151781304780603 0.0206031855887343 0.9999999887102076 0.5174342894999273 17 P04062,P02786,O00560,P27105,Q08380 5 +Lumenal side of endoplasmic reticulum membrane 0.8353365554976935 2.30061906292293 0.021413172565031 0.999999994544403 0.5197425943133687 8 Q8TCT8,P01889,P10321 3 +Exocytic vesicle 0.6488067694028117 2.292484956942381 0.0218776746184239 0.999999996405836 0.5197425943133687 29 O15400,P11279,P50897,O43760,P51790,P05067,Q96A57,Q92542 8 +Phagocytic vesicle 0.6186054009500438 2.1726671068381216 0.0298053811566043 0.9999999999971884 0.6109890286928349 36 Q06481,P01889,P11279,Q9Y487,O00186,P51790,P50995,P04439,P51809,P61421,P10321,Q93050,Q9UNK0 13 +Golgi associated vesicle 0.6293323101026449 2.1555519373077128 0.0311186689627371 0.9999999999991452 0.6109890286928349 27 Q99523,P11717,P24390,P05067,Q8TCT8 5 +Proteasome core complex beta subunit complex 0.8320060675009419 2.1343903070752974 0.0328108443682415 0.999999999999816 0.6109890286928349 7 P20618,Q99436,P49720,P49721,P28072,P28070 6 +Er ubiquitin ligase complex 0.9148609567473012 2.1338931372023127 0.032851529389771 0.9999999999998228 0.6109890286928349 4 Q9UBU6 1 +External encapsulating structure 0.6246699071991471 2.126160224745955 0.033489920724735 0.9999999999999007 0.6109890286928349 27 Q53GQ0,P07858,Q92896,P07602,Q32P28,P50995,P53634,Q5KU26,Q08380 9 +Clathrin coated endocytic vesicle 0.6574120248235388 2.1222352253561376 0.033817989868079 0.9999999999999264 0.6109890286928349 15 P02786,P11717,Q14108,P51809 4 +Cytochrome complex 0.6838147788638638 2.1099700191474957 0.0348609383528031 0.9999999999999716 0.6109890286928349 12 P14406,O14949,P31930,Q9UDW1,P00403,Q9Y276,P20674 7 +Snare complex 0.717511455579625 2.06640766637474 0.0387900026637508 0.9999999999999992 0.6109890286928349 10 Q9UNK0,O15400,Q9P2W9,P51809 4 +Endoplasmic reticulum golgi intermediate compartment 0.5877319993051892 2.0526932790000587 0.0401023343029975 0.9999999999999998 0.6109890286928349 42 Q9Y282,P24390,Q8N511,P80303,O15260,P53634,Q02818,Q15904 8 +Respirasome 0.6043303799437731 2.0525547676049976 0.0401157782444705 0.9999999999999998 0.6109890286928349 34 O96000,O14949,Q96CU9,P31930,Q9UDW1,O43674,O75306,P00403,O43676,Q13423,P14406,Q9Y276,P20674,Q6DKK2 14 +Nadh dehydrogenase complex 0.6158418303963984 2.0502993437586152 0.0403352286003346 0.9999999999999998 0.6109890286928349 18 O96000,Q96CU9,O43676,O75306 4 +Pore complex 0.7699336419325894 2.007720265900762 0.0446730258429801 1.0 0.6109890286928349 8 P45880,P21796,Q9Y277 3 +Intrinsic component of peroxisomal membrane 0.8833923251309566 2.007416517491709 0.0447053315205936 1.0 0.6109890286928349 4 O14975 1 +Recycling endosome membrane 0.6077277253393081 2.001243504513258 0.0453661547443338 1.0 0.6109890286928349 18 Q9H223,P61225,P01889,P02786,P04439,P10321,O15127 7 +Endosome membrane 0.4758951315419771 1.9688680399899543 0.0489682464830014 1.0 0.6109890286928349 100 O15400,P42892,Q8TCT8,Q14108,P11717,P01889,O75787,P51790,P04439,Q93050,Q8IV08,O15127,O00461,Q9UNK0,Q9H223,Q06481,O60831,Q9H4M9,P10321,P55899,Q5T9L3,Q99523,O95772,P11279,Q9Y487,P61225,P02786,P51809,O15118,Q92542,Q15904 31 +Nuclear envelope lumen 0.8255358213419492 1.9264727792715988 0.0540453675591632 1.0 0.6109890286928349 5 P05067 1 +Postsynaptic density membrane 0.8610573820775262 1.916762205360226 0.0552681484931589 1.0 0.6109890286928349 4 Q99720 1 +Proton transporting v type atpase v0 domain 0.8586635140267718 1.907003821153177 0.056520092675397 1.0 0.6109890286928349 4 Q93050,Q9Y487 2 +Vacuolar proton transporting v type atpase v0 domain 0.8586635140267718 1.907003821153177 0.056520092675397 1.0 0.6109890286928349 4 Q93050,Q9Y487 2 +Glial cell projection 0.8585403626881116 1.90650159061036 0.0565851595120154 1.0 0.6109890286928349 4 Q06787,P05067 2 +Tim23 mitochondrial import inner membrane translocase complex 0.8097296454298162 1.90347193369653 0.056978992540204 1.0 0.6109890286928349 6 Q99595 1 +Mhc protein complex 0.9341158652025732 1.8881764148678863 0.0590022709750188 1.0 0.6109890286928349 3 P01889,P10321 2 +Mhc class i protein complex 0.9341158652025732 1.8881764148678863 0.0590022709750188 1.0 0.6109890286928349 3 P01889,P10321 2 +Membrane microdomain 0.525838351481479 1.8877506016134615 0.0590594396691275 1.0 0.6109890286928349 55 P05026,O75955,P46108,Q8WTV0,P61225,P50897,O00560,P35613,P27105,P05067,P21796,O15118,O00592,P04899,O14773,Q14254 16 +Neuromuscular junction 0.6359773751276392 1.849054539287118 0.0644499378295644 1.0 0.6109890286928349 12 Q15375,P10644,O43760,P05067,P07196 5 +Microbody membrane 0.5828935883979335 1.845973566698201 0.0648960436170642 1.0 0.6109890286928349 21 P28288,O14975,O15228,P51648,Q15067,O00116,Q7Z434,Q9NR77,Q9Y3D6 9 +Outer mitochondrial membrane protein complex 0.6063737075558179 1.8287051727106096 0.0674437871532598 1.0 0.6109890286928349 15 Q15388,O96008,Q9NS69,Q6UXV4,Q9BUR5,Q5XKP0,Q8N4H5,Q13505 8 +Apical plasma membrane 0.5622394401841875 1.8226782389409617 0.0683521380378084 1.0 0.6109890286928349 39 P05026,O75955,P07858,O75787,P55011,P51790,P53985,Q99808,Q16625,P61421,P36551,P08195,O00592,Q9Y6M7,P08183,Q8TAD4,Q14254,O00186 18 +Apical part of cell 0.5305345577683254 1.813872254224142 0.0696973952547783 1.0 0.6109890286928349 51 P05026,O75955,P07858,O75787,P51790,P53985,P05067,Q99538,Q16625,Q9Y6M7,P08195,O00592,P08183,Q8TAD4,Q14254 15 +Tertiary granule membrane 0.6953556773033309 1.8074162012021329 0.0706974097432473 1.0 0.6109890286928349 9 O75787,P10253,P27105 3 +Presynapse 0.4324137484716852 1.781936763621464 0.0747595445016704 1.0 0.6109890286928349 73 O75955,O15400,P11279,Q9UQB8,P50897,O00429,O43760,P51790,P05067,Q07021,Q99808,Q96A57,P51116,Q92542,Q06787 15 +Collagen containing extracellular matrix 0.5703772089089003 1.7684660846924347 0.0769830172106809 1.0 0.6109890286928349 24 P53634,Q08380,P07858,P07602 4 +Sarcolemma 0.5670159260301068 1.7484557695442866 0.080385138119571 1.0 0.6109890286928349 19 P05026,O75955,P11279,P35613,Q92542 5 +Intrinsic component of mitochondrial inner membrane 0.5634607113733588 1.7392746100157168 0.0819864711444222 1.0 0.6109890286928349 29 Q99595,P17152,Q9H3K2,Q9NX63,Q6P4A7,O60830,O43819,Q6UXV4,Q15070,Q00325,Q9BUR5,Q5XKP0,O14925,O95563,Q96NB2,Q13505 16 +Endoplasmic reticulum tubular network 0.6523297754586665 1.733158157150111 0.0830675618601823 1.0 0.6109890286928349 10 Q9H6H4,Q9H2C2,P50402 3 +Endolysosome lumen 0.9939439818319454 1.712332524180081 0.0868354061644751 1.0 0.6109890286928349 2 P07858 1 +Cortical endoplasmic reticulum 0.888540772721571 1.7065036247900514 0.087914352004486 1.0 0.6109890286928349 3 P50402 1 +Specific granule membrane 0.6021326013526886 1.7058315938666238 0.0880394389530776 1.0 0.6109890286928349 13 P27105,P30519,P61225,O14975 4 +Golgi lumen 0.8862788245964675 1.697440519884707 0.0896134073838186 1.0 0.6109890286928349 3 P05067 1 +Clathrin coated vesicle 0.5408496426449924 1.6814234919445836 0.0926806856750184 1.0 0.6109890286928349 40 Q99523,P11717,Q5VW38,P42892,Q14108 5 +Copii coated er to golgi transport vesicle 0.5550475164773088 1.67859677046654 0.0932306564081766 1.0 0.6109890286928349 28 P01889,Q9Y282,P05067,P53634,P10321 5 +Platelet alpha granule 0.5551739188196056 1.6766515962045685 0.0936106309784066 1.0 0.6109890286928349 18 Q9NTK5,Q06481,P51809,P05067,Q9NUQ9,Q9UHQ9,Q8NBX0 7 +Vesicle lumen 0.4663319562760718 1.6750469586186656 0.0939250185873337 1.0 0.6109890286928349 116 Q9NTK5,P16278,O00584,P10619,P61916,P08236,P06280,P05067,Q92820,P15586,P07686,O75874,P04066,P53634,Q9BTY2,P17900,O00754,Q08380 18 +Cytoplasmic ubiquitin ligase complex 0.7268653390778483 1.6731753917444163 0.0942927732567613 1.0 0.6109890286928349 7 Q9UBU6 1 +Endolysosome 0.6948041448174828 1.6591806862078826 0.0970793882487865 1.0 0.6176241548643174 8 P07858 1 +Proteasome core complex 0.5751765838843836 1.6444444306173178 0.1000844338612494 1.0 0.6176241548643174 15 Q92530,P28074,P20618,Q99436,P49720,P49721,P28072,P28070 8 +Clathrin coated vesicle membrane 0.5459056728741674 1.6125709595839728 0.1068377519351473 1.0 0.6235184919295116 20 P02786,P11717,Q14108,P51809 4 +Smooth endoplasmic reticulum 0.6262800232394243 1.5966692584333066 0.1103394516596218 1.0 0.6235184919295116 10 P05067 1 +Respiratory chain complex iii 0.7362483666763087 1.590807138372769 0.1116529859725923 1.0 0.6235184919295116 6 P31930,Q9UDW1,Q9Y276,O14949 4 +Inner mitochondrial membrane protein complex 0.4568425189671456 1.590211607943926 0.1117871148517339 1.0 0.6235184919295116 64 O96000,Q99595,O60830,O14949,Q96CU9,Q9UDW1,O75306,O43676,P14406,Q9BUR5,Q5XKP0,Q13505,O75964 13 +Early endosome membrane 0.5343854100354993 1.5886439890333264 0.1121407909685168 1.0 0.6235184919295116 36 Q9H223,O15400,P01889,Q06481,Q9H4M9,P51790,P04439,P10321,Q8IV08,Q5T9L3 10 +Intrinsic component of mitochondrial membrane 0.5273733526901255 1.5822012092024236 0.1136036444300054 1.0 0.6235184919295116 40 Q99595,P12235,P17152,Q9H3K2,O43819,O14925,Q13505,O60830,Q15070,Q00325,Q5XKP0,Q9Y3D6,O96008,Q6P4A7,Q6UXV4,Q96NB2,Q15388,Q9BUR5,O95563,O95140 20 +Golgi apparatus subcompartment 0.4286817098348409 1.5792613298587337 0.1142761277672013 1.0 0.6235184919295116 70 Q10472,P11717,P04062,Q99523,Q10713,P05067,P04439,Q8N2H4,Q8N6G5,Q96A57,P51809,P20645,P35670,O15127,Q9NPR9,O00461,Q9UNK0 17 +Postsynaptic specialization membrane 0.732930432580663 1.5764824036867402 0.114914670867555 1.0 0.6235184919295116 6 Q99720 1 +Trans golgi network transport vesicle 0.5936592788290147 1.5684120488555433 0.1167850009956914 1.0 0.6297792384982379 11 P11717 1 +Golgi cisterna 0.5610523527155257 1.559864103185841 0.1187919989937751 1.0 0.6299225243205434 15 Q99523,Q10472,Q10713,P51572,P04439,Q10471,Q8N6G5,O00461 8 +Trans golgi network membrane 0.5372803528773978 1.555050268554844 0.1199340977317588 1.0 0.6299225243205434 21 P11717,P53365,P05067,Q8N2H4,P20645,P35670,O15127 7 +Endosome 0.5063602012092157 1.5353396440941682 0.1247004209121838 1.0 0.6416500830847406 171 Q13510,O15400,P07858,P07602,P05067,Q13501,Q99538,P42892,Q8TCT8,Q14108,Q92544,P11717,O14786,Q5VW38,P01889,O75787,P10644,P51790,Q8IY95,P04439,Q93050,P20645,Q8IV08,O15127,O14773,P35670,O00461,Q9BUN8,Q9UNK0,Q9H223,Q06481,O60831,Q9UIQ6,P35613,Q96A57,P10321,P55899,Q99523,O95772,O75955,P11279,Q9Y487,P61225,P02786,O95630,Q9NX40,P51809,O15118,Q92542,Q15904,Q14254 51 +Mitochondrial permeability transition pore complex 0.7662083265475504 1.5247280230215627 0.1273269491211288 1.0 0.6416500830847406 4 P21796 1 +Autolysosome 0.9458743376230124 1.5155765309989386 0.1296264651477983 1.0 0.6416500830847406 2 P11279 1 +Secondary lysosome 0.9458743376230124 1.5155765309989386 0.1296264651477983 1.0 0.6416500830847406 2 P11279 1 +Tertiary granule 0.5235844868869467 1.5110854137406078 0.1307666904986602 1.0 0.6416500830847406 36 Q13510,P10253,O15400,P11279,P61225,O75787,P27105,Q92820,P42785,O75874,Q93050 11 +Presynaptic active zone 0.5749726755807899 1.463312369520425 0.1433819245839063 1.0 0.6600061158744348 11 O75955,P05067 2 +Presynaptic membrane 0.574951726602954 1.4631940142844582 0.1434142982161741 1.0 0.6600061158744348 11 Q92542 1 +Dendritic shaft 0.749554624841484 1.454991273910749 0.145671677272531 1.0 0.6600697001357654 4 P05067 1 +Flotillin complex 0.7000337562862579 1.4336277364311436 0.151678523992508 1.0 0.6602558663967578 6 O75955 1 +Atpase dependent transmembrane transport complex 0.8087684274536028 1.3852618685587983 0.1659724088750227 1.0 0.6694054476850083 3 P05026 1 +Cation transporting atpase complex 0.8087684274536028 1.3852618685587983 0.1659724088750227 1.0 0.6694054476850083 3 P05026 1 +Sodium potassium exchanging atpase complex 0.8087684274536028 1.3852618685587983 0.1659724088750227 1.0 0.6694054476850083 3 P05026 1 +Messenger ribonucleoprotein complex 0.6957217004564801 1.375720962998443 0.168908039258528 1.0 0.672506470167679 5 Q99729,Q06787 2 +Mitochondrial proton transporting atp synthase complex coupling factor f o 0.6933934247604292 1.3656662901136103 0.1720437295242729 1.0 0.6751858948583297 5 O75964 1 +Triglyceride rich plasma lipoprotein particle 0.9080242240726704 1.360735525525406 0.1735972835471928 1.0 0.6751858948583297 2 Q9UHG3 1 +Origin recognition complex 0.7253910277004998 1.3535488747639124 0.1758803471523213 1.0 0.6768238942267468 4 Q9Y619 1 +Golgi cisterna membrane 0.5483906094386479 1.3521466410330796 0.176328409303669 1.0 0.6768238942267468 12 Q99523,Q10472,Q10713,P51572,Q10471,Q8N6G5,O00461 7 +Acrosomal membrane 0.904239212717638 1.3452872418055213 0.1785324920201692 1.0 0.682304610807516 2 P35613 1 +Neuronal ribonucleoprotein granule 0.7951533510034127 1.3303140814386845 0.1834148095395951 1.0 0.6855138764331471 3 Q99729,Q06787 2 +Intrinsic component of mitochondrial outer membrane 0.5996529891650257 1.3283833191999257 0.1840515072107198 1.0 0.6855138764331471 9 Q15388,Q9Y3D6,O96008,O95140 4 +Specific granule 0.4992879767337864 1.3008526382515402 0.1933089002720625 1.0 0.6928588250364477 29 P30519,P61225,O14975,P27105,P51790,P50995,Q92820,O00264,Q7L576,Q07065 10 +Proton transporting two sector atpase complex 0.4984398605586083 1.2934537690753742 0.1958541637236441 1.0 0.6928588250364477 24 Q9Y487,Q8N511,Q93050,Q15904,O75964 5 +Er membrane insertion complex 0.7854119262339877 1.291031063893428 0.1966929061162385 1.0 0.6928588250364477 3 P46379 1 +Cytolytic granule 0.7839017075658202 1.2849445181247772 0.1988116726869138 1.0 0.6928588250364477 3 P11279 1 +Respiratory chain complex iv 0.6405997233183517 1.2799440750104598 0.2005648051442667 1.0 0.6928588250364477 7 P20674,P14406 2 +Synaptic vesicle membrane 0.615543514831795 1.2793480482873256 0.2007745196561914 1.0 0.6928588250364477 8 P51149,O00429,O43760 3 +Autophagosome membrane 0.5412772415121847 1.2715675097483718 0.2035268267744738 1.0 0.6928588250364477 11 O75787,P11279 2 +Secretory granule 0.515235440678106 1.264798740289263 0.2059434830874313 1.0 0.6928588250364477 215 Q13510,Q9NTK5,O15400,P07858,Q9H7Z7,O00584,P06280,P07602,P05067,O15260,P15586,O75874,P42892,Q9BTY2,Q08380,P06865,P11717,Q9NQX7,P20618,P16278,P01889,O14975,P45880,O00462,P61916,O75787,P27105,P51790,Q93050,P30519,Q06481,P10619,O00560,P35613,Q92820,P42785,P04066,P53634,P10321,Q8TAD4,P17900,P10253,P11279,Q9Y487,Q9UQB8,P61225,P08236,O00264,P51809,P07686,Q92542,O00754,Q14254 53 +Protein lipid complex 0.7779961306258628 1.2611549155666937 0.2072530383961663 1.0 0.6928588250364477 3 Q9UHG3 1 +Ciliary base 0.6689918404249854 1.2601007347617208 0.2076330252564635 1.0 0.6928588250364477 5 A0AVF1 1 +Nuclear outer membrane 0.5851791403150451 1.2544196904504772 0.2096894992869749 1.0 0.6928588250364477 9 Q99720,Q9UBM7 2 +Neuron projection terminus 0.5236426334452384 1.2475513084101797 0.2121954193696746 1.0 0.6928588250364477 13 P51790,Q9UQB8 2 +Oxidoreductase complex 0.4682165872217624 1.2425604241349186 0.2140298612206252 1.0 0.6928588250364477 48 O96000,O14949,Q96CU9,O75306,Q9UDW1,P11177,O43676,O43169,Q5VT66 9 +Ficolin 1 rich granule membrane 0.4925107341887136 1.2279350914461231 0.2194713351280268 1.0 0.6928588250364477 17 Q93050,P42785,P10253,P11279 4 +Astrocyte projection 0.8739591218773621 1.222143606987664 0.2216533250865735 1.0 0.6928588250364477 2 P05067 1 +Tertiary granule lumen 0.5122320996517287 1.2200492596481054 0.222446201798242 1.0 0.6928588250364477 14 Q13510,Q92820,O75874 3 +Mcrd mediated mrna stability complex 0.6926179116253854 1.2158099656537715 0.2240573216273085 1.0 0.6928588250364477 4 O60506 1 +Basolateral plasma membrane 0.4831892239238557 1.1923777305306524 0.2331131682467775 1.0 0.6959855446912754 31 P05026,O75955,P02786,P55011,P35613,P53985,P78310,Q99808,Q6P4Q7,Q9Y6M7,P08195,P35670,Q14254,O00186 14 +Late endosome 0.4518808030734996 1.1827375428377929 0.2369131803223354 1.0 0.6959855446912754 52 O15400,P07602,Q13501,Q99538,Q8TCT8,Q14108,P11717,P10644,P51790,Q8IY95,P20645,Q8IV08,P35670,Q9BUN8,Q96A57,O95772,P11279,P51809,O15118 19 +Nuclear outer membrane endoplasmic reticulum membrane network 0.5317648160700663 1.1783555676487494 0.2386548834733721 1.0 0.6959855446912754 255 Q92604,P57088,P07099,Q9BQE5,P48651,Q16850,Q8TC12,Q6NUM9,Q8TCT8,Q14108,Q8N5K1,O76024,Q9NQC3,Q969V3,O75844,Q8IV08,Q9UBM7,Q5BJF2,P24390,O60725,Q15392,Q15629,P10321,Q99523,O95772,Q8N511,Q06136,Q99720,Q86XL3,Q15904,Q8TB61,Q9Y282,O15260,O43852,P67812,Q96G23,Q9UBU6,P43307,P01889,O14975,O75787,O75845,P04439,Q14739,Q8NFQ8,Q96GC9,Q9BUN8,P30519,Q96N66,P50402,O00560,P35613,Q9H2C2,O95197,Q9Y5P4,Q9HD20,O00264,P51809,Q9BUR5,Q9P2W9,Q9NZ08,Q9H6H4,O15269,O00429,O75477,Q15041,Q99735,Q9UKR5,Q6P1A2,P48449,O95470,Q10472,Q9Y4P3,P51648,Q96A33,Q5T9L3,Q53GQ0,O14880,Q14534,Q9BV10,P16435,O15270,Q9BRR6,Q8N2K0,Q9Y5M8,Q9H8Y8,Q9NPA0,Q96PC5,P16615,Q9Y320,Q9BT22,Q07065,P62942,P22059,P09601,P20073,Q10471,P37268,Q9UHQ9,Q13190,Q15005,Q8N2F6,Q96S66,Q8TEM1 104 +Coated vesicle membrane 0.4533506299117264 1.1746846206427286 0.240120914497514 1.0 0.6959855446912754 51 P11717,P01889,P02786,P24390,Q8N511,P04439,P10321,Q14108 8 +Phagophore assembly site 0.6473259336254783 1.1662204777608232 0.243525315213184 1.0 0.6959855446912754 5 Q13501 1 +Ciliary transition zone 0.6375544068174882 1.1592209671358418 0.2463661270303545 1.0 0.6974749104298117 6 A6NIH7,Q15555 2 +Nucleotide activated protein kinase complex 0.7486699639028178 1.1434090757359925 0.2528687860699716 1.0 0.7006316203867662 3 P10644 1 +Endoplasmic reticulum palmitoyltransferase complex 0.8531415594246778 1.1381329258508344 0.2550649812557055 1.0 0.7006316203867662 2 O15269 1 +Palmitoyltransferase complex 0.8531415594246778 1.1381329258508344 0.2550649812557055 1.0 0.7006316203867662 2 O15269 1 +Platelet alpha granule lumen 0.5032005550680959 1.1256641189851475 0.2603077167923566 1.0 0.7036143585798563 13 Q9NTK5,Q9NUQ9,P05067 3 +Golgi apparatus 0.5225305866529246 1.1240888219736962 0.2609753468739322 1.0 0.7036143585798563 247 Q8TB61,O75503,Q6ZRP7,Q9Y282,Q9H7Z7,P50897,P06280,P80303,P05067,O15260,O43852,Q8IZA0,Q14108,Q92544,P11717,Q9NQX7,Q5VW38,P16278,Q8N2A8,P01889,Q10713,O00429,P51790,Q8IY95,P04439,Q8N2H4,Q16739,Q93050,P20645,Q8IV08,O15127,O14773,Q9NPR9,O00461,P35670,Q9UNK0,P04062,P24390,Q92896,P35613,Q15392,Q9H2C2,Q96A57,P53634,P10321,Q8TAD4,O95197,O43505,Q99523,Q9UQB8,Q9Y5P4,Q8NCH0,Q9NX40,P51809,Q9BUR5,O15118,Q92542,Q02818,Q9P2W9 59 +Golgi associated vesicle membrane 0.4758794449969634 1.1209174203706742 0.2623230149718809 1.0 0.7036143585798563 17 P24390,Q8TCT8 2 +Proton transporting two sector atpase complex proton transporting domain 0.5139277190613415 1.1142922527991974 0.2651538294813997 1.0 0.7036143585798563 11 Q93050,Q9Y487,O75964 3 +Apicolateral plasma membrane 0.633700400867386 1.10720250801764 0.2682063834541024 1.0 0.7036143585798563 5 Q16625 1 +Mitochondria associated endoplasmic reticulum membrane 0.5553395920196579 1.1011968398202776 0.2708109968084631 1.0 0.7036143585798563 9 Q15388,O96008,Q96N66,P51572,Q96S66,Q9Y320 6 +Plasma membrane raft 0.4786808251659409 1.0957280761512804 0.2731977921135313 1.0 0.7036143585798563 16 P05026,O75955,Q8WTV0,Q14254 4 +Secretory vesicle 0.5114497274681767 1.092656308854406 0.2745447296318444 1.0 0.7036143585798563 233 Q13510,Q9NTK5,O15400,P07858,Q9H7Z7,O00584,P50897,P06280,P07602,P05067,O15260,P15586,O75874,P42892,Q9BTY2,Q08380,P06865,P11717,Q9NQX7,P20618,P16278,P01889,O14975,P45880,O00462,P61916,O75787,P27105,P51790,Q93050,P30519,Q06481,P10619,O00560,P35613,O43760,Q92820,P42785,Q96A57,P04066,P53634,P10321,Q8TAD4,P17900,P10253,P11279,Q9Y487,Q9UQB8,P61225,P08236,O00264,P51809,P07686,Q92542,O00754,Q14254 56 +Ubiquinone biosynthesis complex 0.8417865253595758 1.092617696827218 0.2745616894117073 1.0 0.7036143585798563 2 Q9NZJ6 1 +Ficolin 1 rich granule 0.3757951503687103 1.0793681321791049 0.2804236513504214 1.0 0.7165476440029664 83 Q13510,P10253,P11279,P16278,P07858,P20618,P08236,P42785,P15586,O75874,Q93050 11 +Platelet dense tubular network membrane 0.8345950037850107 1.063926239809967 0.2873621150162433 1.0 0.7216894259979367 2 Q9H4M9 1 +Platelet dense tubular network 0.8345950037850107 1.063926239809967 0.2873621150162433 1.0 0.7216894259979367 2 Q9H4M9 1 +Trans golgi network 0.4358400122075248 1.0440307283792631 0.2964711730184843 1.0 0.7320173064136173 52 Q4J6C6,P05067,P11717,P53365,Q8N2H4,Q7Z6M1,O14828,P20645,P35670,O15127,Q10567,Q9NPR9,Q9UNK0,P04062,P22059,P98194,Q96A57,Q5T9L3,P51809,Q9HAS0 20 +Platelet alpha granule membrane 0.8224829674488979 1.0158730792706911 0.309689829976177 1.0 0.7432445773054482 2 Q06481 1 +Schaffer collateral ca1 synapse 0.4784895031487133 1.014515080916223 0.3103370370114224 1.0 0.7432445773054482 14 Q9UQB8 1 +Caveola 0.48268631454929 1.0027657049761982 0.3159739194508419 1.0 0.7432445773054482 13 P05026,O75955,Q8WTV0 3 +Signal peptidase complex 0.8183194549583614 0.999440576639681 0.317581311740355 1.0 0.7432445773054482 2 P67812 1 +Chromocenter 0.607358339276076 0.9934168811843416 0.3205068382408971 1.0 0.7433390786642442 5 P83916,Q06787 2 +Pole plasm 0.7065505490344595 0.976314418003799 0.3289086772040694 1.0 0.7561744918924792 3 Q9HCE1,Q9Y2W6 2 +Lamellar body 0.809235427706282 0.9637557696676934 0.3351683865674273 1.0 0.7561744918924792 2 Q07065 1 +Neuron spine 0.4448402949717941 0.9217230746975932 0.3566730413628201 1.0 0.7612509748627372 26 Q9UQB8,O75787,P05067,P51116,Q06787 5 +Dendrite cytoplasm 0.4797363552357729 0.916685296042917 0.3593075733651274 1.0 0.7617299600471726 11 Q9UQB8,Q14254 2 +Tight junction 0.4377451656895162 0.9004025574905196 0.3679060602815001 1.0 0.7718124749103545 20 Q16625,Q9NR77,P61225 3 +Sorting endosome 0.7819833459500352 0.8583054529165351 0.3907238192146578 1.0 0.7875433634593212 2 O14786 1 +Mib complex 0.4887903276214825 0.8549493922545369 0.3925791650558765 1.0 0.7875433634593212 10 Q13505,Q9BUR5 2 +Excitatory synapse 0.6003068865335405 0.8331463405384708 0.404762201120588 1.0 0.7934880200176285 4 Q9UQB8 1 +Organelle subcompartment 0.5230021971632293 0.8160480625123312 0.4144726473281781 1.0 0.8004400001604054 306 Q4J6C6,Q92604,P57088,P07099,Q9BQE5,P48651,P05067,Q16850,Q8TC12,Q6NUM9,Q8TCT8,Q14108,Q8N5K1,O76024,P11717,Q9NQC3,Q969V3,P51572,Q8N2H4,O75844,Q7Z6M1,Q8IV08,Q9UBM7,Q10567,Q9NPR9,O00461,P46977,P18031,Q5BJF2,Q9HCU5,P24390,P98194,P61019,O60725,Q15392,Q9H2M9,Q15629,P10321,Q9BWS9,Q8N0U8,Q99523,O95772,Q8N511,Q06136,Q99720,Q86XL3,Q15904,Q8TB61,Q9Y282,O15260,O43852,P67812,Q96G23,Q9UBU6,P43307,P01889,O14975,O75787,O75845,P04439,Q14739,Q8NFQ8,O15127,Q96GC9,Q9BUN8,P04062,P30519,Q96N66,P50402,O00560,P35613,Q9H2C2,Q96A57,O95197,Q9Y5P4,Q9HD20,O00264,P51809,Q9BUR5,Q9P2W9,Q9NZ08,Q10713,Q9H6H4,O15269,O00429,O75477,Q15041,Q99735,Q9UKR5,Q6P1A2,P20645,P48449,P35670,O95470,Q9UNK0,Q10472,Q9Y4P3,P51648,Q96A33,Q8N6G5,Q5T9L3,Q00765,Q53GQ0,O14880,Q14534,Q9BV10,P16435,O15270,Q9BRR6,Q8N2K0,Q9Y5M8,P53365,Q9H8Y8,Q9NPA0,Q96PC5,P16615,O14828,Q9Y320,Q9BT22,Q07065,P62942,P22059,P09601,P20073,Q10471,P37268,Q9UHQ9,Q13190,Q15005,Q8N2F6,Q96S66,Q9HAS0,Q8TEM1 133 +Organelle envelope lumen 0.4305755983644949 0.8146977801989206 0.4152453243152956 1.0 0.8004400001604054 32 O00584,P05067 2 +Multivesicular body 0.5161482544518763 0.7958946490875892 0.4260932716568315 1.0 0.807344298483491 8 P10644,P11279 2 +Nucleoid 0.4269956979636763 0.7919572728012869 0.4283855902171862 1.0 0.807344298483491 28 P21796 1 +9plus2 motile cilium 0.4178830281825945 0.7673751649558963 0.4428584900379888 1.0 0.8160123595083539 20 Q15388,P05026,P05023,P10644,Q13501 5 +Photoreceptor outer segment 0.5535256461410032 0.7643214981409012 0.444675677138227 1.0 0.8160123595083539 5 P35613 1 +Endoplasmic reticulum 0.5365589708468307 0.7469215334994737 0.4551109268619235 1.0 0.8287980037132747 407 O75503,O00584,Q9BQE5,P80303,P05067,Q16850,Q9BTY2,Q8TCT8,Q14108,Q9H6V9,P61916,P27105,O75844,Q8IV08,Q9UBM7,Q5BJF2,Q06481,P10619,P24390,O60725,Q15392,Q15629,P53634,P10321,Q99523,O95772,Q9UQB8,Q8N511,O15173,Q06136,Q99720,Q86XL3,Q9Y680,O15118,Q92542,Q02818,Q15904,Q13510,Q8TB61,Q9Y282,P30536,Q8NBQ5,Q14257,Q13501,O15260,O43852,P67812,Q96G23,Q9UBU6,P43307,P01889,O14975,O75787,Q9NWM8,O75845,Q9UMX5,Q8IY95,P04439,Q14739,Q8NFQ8,Q9Y3D6,Q96GC9,Q9BUN8,P04062,P30519,Q96N66,P50402,O00560,P35613,Q32P28,Q9H2C2,Q96A57,O95197,O75718,Q9Y5P4,Q9HD20,O00264,P51809,Q9BUR5,O60506,Q9P2W9,O95881,Q96LJ7,Q9H2J4,Q92791,Q9NZ08,Q9H6H4,O15269,O00429,O75477,Q15041,Q99735,Q9UKR5,Q6P1A2,P48449,O95470,Q9UNK0,Q10472,Q9H223,P48723,O43681,O43390,Q9Y4P3,P51648,Q96A33,Q5T9L3,Q00765,Q53GQ0,O14880,P13674,Q14534,Q9Y3E0,P00367,Q9BV10,P16435,O60879,O15270,Q9BRR6,O95456,Q9BRK5,Q8N2K0,Q9Y5M8,Q92530,Q9H8Y8,Q9NPA0,Q96PC5,P16615,Q9Y320,Q9BT22,Q15293,Q07065,P62942,P22059,P09601,P20073,Q10471 136 +Nuclear inner membrane 0.4164395313329363 0.7358600668742156 0.4618158616157211 1.0 0.8287980037132747 17 Q99720,Q14739,O75844 3 +Neurofilament 0.5749778794464827 0.7318643492602268 0.4642513679164235 1.0 0.8287980037132747 4 O14786 1 +Copi coated vesicle 0.4367196782953 0.7275334376049687 0.4668992394124647 1.0 0.8298163981229678 13 P24390 1 +Copi coated vesicle membrane 0.4405324003085132 0.7198255446813261 0.4716324148836692 1.0 0.8307680934543644 12 P24390 1 +Rdna heterochromatin 0.7445117335351977 0.7183497354747558 0.4725416710080077 1.0 0.8307680934543644 2 O43159 1 +Perikaryon 0.4093075037750439 0.717909070368455 0.4728133548146678 1.0 0.8307680934543644 19 Q06787,P05067 2 +Endoribonuclease complex 0.4410540181832665 0.6942300769562451 0.4875379334230572 1.0 0.8386415723656894 11 Q99598,Q99575,Q9Y4W2,Q7L0Y3,O75569,Q5KU26 6 +Clathrin coated pit 0.4086283616583955 0.6914681173208608 0.4892714100224373 1.0 0.8399796277533642 22 Q99523,P05067 2 +Beta catenin destruction complex 0.5617424242424331 0.6800516663135595 0.4964717471049464 1.0 0.8457338482659844 4 P49841,Q9HB71,P35222 3 +Golgi stack 0.4051442405986841 0.6615881542736884 0.5082352012754989 1.0 0.8585555909576579 23 Q10472,Q99523,Q10713,P04439,O00461 5 +Organelle membrane contact site 0.4100815799877562 0.660579202224684 0.5088822103400907 1.0 0.8585555909576579 16 Q15388,O96008,O95772,Q96N66,Q9NTJ5,P51572,Q96S66,Q5XKP0,Q9Y320 9 +Micos complex 0.5268603046869671 0.6541355281635667 0.5130244937991171 1.0 0.8622342830772923 5 Q9BUR5,Q6UXV4,Q5XKP0 3 +Cell trailing edge 0.5213098015801525 0.6316065087654186 0.5276440324149885 1.0 0.870342539177415 5 O75955 1 +Filopodium 0.4045716812454369 0.6287090199778407 0.5295395718475175 1.0 0.870342539177415 30 Q9UQB8,P05067,P78310,O00592,P51116,P51114,Q06787 7 +Intrinsic component of synaptic vesicle membrane 0.5173989467919058 0.615830292659626 0.5380065320556064 1.0 0.8784220339419845 5 P51149 1 +Vesicle membrane 0.4512448273446164 0.5996592476631812 0.5487333528364318 1.0 0.8819463494686984 208 P07602,O15260,P42892,Q8TCT8,Q14108,P11717,Q9NQX7,P01889,O14975,O75787,O00462,P27105,P51790,P04439,Q93050,Q8IV08,O15127,O00461,P30519,Q06481,P11233,Q8WTV0,O60831,P24390,Q9UIQ6,P35613,O43760,P42785,P10321,Q8TAD4,P55899,Q5KU26,Q99523,O95772,P10253,P11279,Q9Y487,P61225,P02786,Q8N511,O00264,P51809,O15118,Q92542,Q15904,Q14254 46 +Acrosomal vesicle 0.4050116885050316 0.5974299453834622 0.5502203657547113 1.0 0.8825614990846555 15 Q9Y487,P45880,P35613,P78310,P07686,Q14254 6 +Nuclear pore outer ring 0.4711684370257972 0.5824591473072844 0.5602574512599015 1.0 0.892811955750372 8 Q96EE3,P52948,P57740,Q8NFH3,Q12769,Q8WUM0,Q9BW27 7 +Rough endoplasmic reticulum 0.3946697880756326 0.556108982332452 0.5781363549955838 1.0 0.9044182484957874 31 Q5BJF2,Q9UQB8,Q15041,P05067,Q96A33,Q9Y5M8 6 +Basal part of cell 0.394213900895034 0.5549988868547512 0.5788954218314315 1.0 0.9044182484957874 38 P05026,O75955,P02786,P55011,P35613,Q15758,P53985,P78310,P42785,Q99808,Q6P4Q7,Q9Y6M7,P08195,P35670,Q14254,O00186 16 +Bleb 0.5010640296006826 0.5509018201326527 0.581700979689566 1.0 0.9044182484957874 5 Q9NQW6 1 +Rna cap binding complex 0.5253039195724238 0.542608755713025 0.5873992092282461 1.0 0.9044182484957874 4 Q06787 1 +Cell cell contact zone 0.3835100925138007 0.5392616195288278 0.5897063476735913 1.0 0.9046280621380224 20 P05026,Q14126,O75955,P61225 4 +Autophagosome 0.3863339989357113 0.5281377579463425 0.5974037258503571 1.0 0.912257757145224 24 Q13501,P11279,Q96GC9,O75787 4 +Chromaffin granule 0.688493565480692 0.5245886897994385 0.5998691508873031 1.0 0.912257757145224 2 P20073 1 +Chromaffin granule membrane 0.688493565480692 0.5245886897994385 0.5998691508873031 1.0 0.912257757145224 2 P20073 1 +Late endosome membrane 0.3859653798380049 0.50883331504389 0.6108690653563329 1.0 0.9210187108888792 27 O95772,Q8IV08,P11279,P51790,Q8TCT8,Q14108 6 +Perinuclear region of cytoplasm 0.4100487881202064 0.505856700413986 0.6129572508818351 1.0 0.9224460828632752 166 Q9NWT6,O15400,O75503,P07858,Q9H7Z7,P05067,Q99538,P42892,Q9H2J4,Q06787,P11717,Q9NQX7,P16278,O00429,P27105,Q8IY95,Q93050,P20645,P35670,P51114,Q9UNK0,Q10472,Q9H223,Q9UIQ6,Q99523,P11279,Q9Y487,Q9Y5P4,P02786,O15118,Q14254 31 +Ciliary basal body 0.389689724211517 0.5044935002474854 0.6139146285267532 1.0 0.9224460828632752 15 P28070 1 +Photoreceptor connecting cilium 0.5140489552967087 0.5020391550866399 0.6156399785646047 1.0 0.9225628031767072 4 Q15555 1 +Mitochondrial protein containing complex 0.3775411403573787 0.4894126423980943 0.6245495873976026 1.0 0.928898624911155 132 Q99595,Q9UDW1,P11177,P21796,Q13505,O96000,O60830,Q567V2,Q5XKP0,O75964,Q9NS69,Q8N4H5,P14406,O14949,Q96CU9,O43676,O75306,Q9BUR5,Q9Y291 19 +Apical junction complex 0.3758274184141558 0.46485442676408 0.6420357084112067 1.0 0.9357185336567616 23 Q16625,Q9NR77,P61225 3 +9plus0 non motile cilium 0.4451495801806814 0.4636811245964232 0.6428762225179896 1.0 0.9357185336567616 8 P35613,Q15555 2 +Ciliary tip 0.4702944351954905 0.4442638411015828 0.6568518405063859 1.0 0.9419184695910432 6 A0AVF1 1 +Lateral plasma membrane 0.3668687293022998 0.4212026846836289 0.673607084127569 1.0 0.950300802299988 17 Q8TAA9,P55011,P53985,P05026 4 +Lipid droplet 0.3722780336206266 0.4102901583196701 0.6815931107062234 1.0 0.950300802299988 28 Q8NBX0,Q9H4M9,Q8NBQ5,O43760,Q99720,Q8N0X7,P48449,Q9H6V9,Q07065 9 +Endoplasmic reticulum protein containing complex 0.3627785039693909 0.4043481705043925 0.6859567076130191 1.0 0.950300802299988 52 P62942,Q53GQ0,P13674,O15270,O15269,O43681,Q15041,Q9NPA0,P04439,P67812,Q9UBU6,Q9BUN8,Q9Y5M8 13 +Brisc complex 0.648750946252833 0.4025448749747192 0.687283069573631 1.0 0.950300802299988 2 P34897 1 +Cilium 0.3075369037185893 0.3937559095814129 0.6937612590766173 1.0 0.950300802299988 74 P05026,A0AVF1,Q10713,Q9H4M9,P10644,P35613,P05067,Q13501,Q9NUQ9,P28070,A6NIH7 11 +Anchored component of synaptic vesicle membrane 0.4810606060606175 0.3895919919450751 0.696838274671453 1.0 0.950300802299988 4 P61020,Q15286,P51149 3 +Wnt signalosome 0.6434519303557853 0.3874463365642969 0.6984258056387047 1.0 0.950300802299988 2 P49841 1 +Cell division site 0.3580940310913753 0.3847597824431538 0.7004153984129848 1.0 0.950300802299988 19 O95630,P11233,Q9NQW6 3 +Pericentric heterochromatin 0.4260256166571428 0.3797280684117738 0.704147282506669 1.0 0.950300802299988 8 Q9UFC0,P83916 2 +Emc complex 0.4771213232730402 0.3768923285528571 0.7062536226946188 1.0 0.950300802299988 4 Q9NPA0 1 +U6 snrnp 0.4757575757575866 0.3725353610540015 0.7094942892068192 1.0 0.9505221755259634 4 Q9Y333,Q9UK45,P62312 3 +Synaptic membrane 0.3689945720492824 0.36937748788317 0.711846375475899 1.0 0.9505221755259634 33 Q15375,Q9UQB8,P51790,Q99720,Q92542,Q06787 6 +Photoreceptor inner segment 0.4501472785850544 0.367080218417851 0.7135591822988758 1.0 0.9505221755259634 6 P35613,Q15555 2 +Spindle midzone 0.3647296306244076 0.3571968693703568 0.7209444294004279 1.0 0.9558222525535084 15 P05067,Q15555 2 +Filopodium tip 0.448045955606883 0.3541849911610785 0.7232002508193349 1.0 0.957369006732222 5 Q06787 1 +Er to golgi transport vesicle membrane 0.3549503205734481 0.3460253186565825 0.7293236871898432 1.0 0.9611327152022072 21 P01889,P10321 2 +Atac complex 0.4617855274091804 0.3291181574085746 0.742066380449443 1.0 0.972095899277288 4 Q01658 1 +Ficolin 1 rich granule lumen 0.3250513734316692 0.3172622816956293 0.7510445949225402 1.0 0.9727512156503229 66 Q13510,P16278,P07858,P08236,P15586,O75874 6 +Trapp complex 0.4553030303030418 0.3097641879019189 0.7567402868578257 1.0 0.9727512156503229 4 O43617,Q8IUR0,Q9Y296 3 +Sperm midpiece 0.433960635468496 0.306575534940944 0.7591664777430278 1.0 0.9727512156503229 5 Q13501 1 +Rough endoplasmic reticulum membrane 0.3542789529356763 0.2772176900473915 0.7816129570434147 1.0 0.9800824382898168 14 Q5BJF2,Q96A33,Q15041 3 +Lsm2 8 complex 0.496402877697837 0.2712992794482983 0.7861608606109269 1.0 0.9819395314723132 3 Q9Y333,P62312 2 +Scar complex 0.495645588792112 0.2694830103666966 0.7875580145631471 1.0 0.9819395314723132 3 Q8IZP0,Q7L576 2 +Presynaptic active zone membrane 0.5851627554882589 0.2425117889277133 0.8083836232103074 1.0 0.9947912226721012 2 P27824 1 +Organelle inner membrane 0.4173337132544973 0.2382067954562098 0.8117207067922154 1.0 0.996511873282622 205 Q99595,O43819,P20674,Q9UJZ1,Q3ZCQ8,O60830,Q9H061,P00403,Q15070,O75844,Q567V2,Q8N5N7,O75964,P18031,O96008,Q9H2D1,P31930,Q02978,Q6UXV4,Q69YU5,P23786,Q9NX63,Q9NVI7,P14406,P53701,O43676,P43243,Q9Y276,Q99720,Q6NUK1,Q9Y291,Q9HC21,Q9UDW1,P17931,P08574,P05141,O95202,Q86VD7,Q9Y619,Q14728,Q13505,Q6DKK2,Q9Y5J9,P62995,P04818,Q14739,P50402,O43772,Q70HW3,O14949,Q96CU9,O75306,Q9BUR5,Q9H3K2,P17152,Q9UBX3,O96000,Q10713,Q5XKP0,P24539,Q9NPL8,Q9H1E5,Q13423,O95563,P12235,O95831,Q9NZJ6,Q9H2V7,O14925,Q96IX5,Q9BRT2,O75208,O43615,Q00325,P36551,Q9BRJ2,Q6P4A7,O43674,Q96NB2,P12236,P40939,Q8NBN7 82 +Epsilon dna polymerase complex 0.4282093331894005 0.2347771507120835 0.8143817031963394 1.0 0.9969937564200312 4 Q9NR33 1 +Mmxd complex 0.4737924235013006 0.2202747279476518 0.8256572009810801 1.0 1.0 3 P18074 1 +Immunological synapse 0.3465171573861165 0.2031317774634892 0.8390320346428015 1.0 1.0 12 Q96L92,Q9UJZ1,P10644,O15400 4 +Ruffle membrane 0.335307785261829 0.1813664838896111 0.8560799245592718 1.0 1.0 26 P51790 1 +Sex chromatin 0.4519130663650179 0.1774006277078161 0.8591937142975907 1.0 1.0 3 Q99496 1 +Cleavage furrow 0.3314388153453025 0.1732648672786582 0.8624432378379094 1.0 1.0 15 O95630,P11233 2 +Manchette 0.5469341408024169 0.1704384683410199 0.8646653213343276 1.0 1.0 2 Q96SI9 1 +Lamellipodium 0.3380735282615481 0.1686916781310345 0.8660391648599095 1.0 1.0 49 O75955,Q9UQB8,P51809,P05067,O00592 5 +Microbody 0.3410512633969492 0.165892947951986 0.8682411973168578 1.0 1.0 43 O14975,Q15067,Q9NR77,O75874,Q8N4Q0,P48735 6 +Centriolar satellite 0.3195966669715064 0.1527723493000666 0.8785778037941236 1.0 1.0 19 Q86UY6,O75955,O00592 3 +Gemini of coiled bodies 0.3736263736263782 0.1325947788319411 0.8945138618482518 1.0 1.0 5 Q9UHI6,Q16637,P57678,Q8TEQ6 4 +Organellar ribosome 0.3353702055517323 0.1264605362054476 0.8993673857462914 1.0 1.0 37 Q567V2 1 +Meiotic spindle 0.5064345193035482 0.1144382551419104 0.9088903899574768 1.0 1.0 2 Q9NQS7 1 +Cd40 receptor complex 0.4081787201817525 0.111177955266501 0.9114752323943875 1.0 1.0 3 Q9NR28,O15111 2 +Esc e z complex 0.3678030303030353 0.1060918756001486 0.9155094570985032 1.0 1.0 4 Q16576,Q15022,Q09028 3 +Lsm1 7 pat1 complex 0.4962149886449562 0.1034412709683964 0.9176127583129304 1.0 1.0 2 Q9Y333 1 +Chromatin silencing complex 0.3586446920688253 0.098107075026182 0.9218472695730506 1.0 1.0 5 O43159,Q15022 2 +T tubule 0.3554783806637847 0.0913007676804062 0.9272536080172687 1.0 1.0 5 P05026 1 +Dendrite terminus 0.3900037864445233 0.0910035146459189 0.9274897983633996 1.0 1.0 3 Q7L576,P07900 2 +Dendritic growth cone 0.3900037864445233 0.0910035146459189 0.9274897983633996 1.0 1.0 3 Q7L576,P07900 2 +U2af complex 0.4818319454958259 0.0899360861156795 0.9283380047614844 1.0 1.0 2 P26368 1 +Cytoplasmic side of endosome membrane 0.4806964420893168 0.0889639099664465 0.9291105920279944 1.0 1.0 2 Q9UL25 1 +H3 histone acetyltransferase complex 0.4780469341407918 0.0867471999078406 0.9308724576956487 1.0 1.0 2 O94880 1 +Non motile cilium 0.3213366984279406 0.0854257531167593 0.9319229199658672 1.0 1.0 12 P35613,P41208,Q15555 3 +Actin based cell projection 0.3301018967986029 0.0850554764449011 0.932217286630372 1.0 1.0 42 Q9UQB8,P05067,P78310,Q9Y6M7,O00592,P51116,P51114,Q06787 8 +Dynactin complex 0.3511363636363723 0.0804918918002587 0.9358460447180584 1.0 1.0 4 Q13561,O75935,Q9UJW0 3 +Transport vesicle membrane 0.3262872300268304 0.0765497032733817 0.9389817724506696 1.0 1.0 34 P01889,O43760,P51809,P04439,P10321 5 +Box h aca telomerase rnp complex 0.3619840969329815 0.067462576299364 0.9462134539107248 1.0 1.0 3 O60832,Q9NY12 2 +Dendritic tree 0.2987688504789581 0.0663298658563227 0.9471152060604258 1.0 1.0 91 Q15375,Q9UQB8,O75787,P21964,P50897,P05067,Q99729,Q96QD8,P51116,P04899,Q14254,Q06787 12 +Carboxy terminal domain protein kinase complex 0.4409538228614598 0.0626517054207057 0.9500438552839124 1.0 1.0 2 P18074 1 +Transcription factor tfiih holo complex 0.4409538228614598 0.0626517054207057 0.9500438552839124 1.0 1.0 2 P18074 1 +Ribonuclease mrp complex 0.4318697956093826 0.0584870012852408 0.9533607162423448 1.0 1.0 2 Q99575 1 +Nucleolar ribonuclease p complex 0.4318697956093826 0.0584870012852408 0.9533607162423448 1.0 1.0 2 Q99575 1 +Multimeric ribonuclease p complex 0.4318697956093826 0.0584870012852408 0.9533607162423448 1.0 1.0 2 Q99575 1 +Female pronucleus 0.3467984511556622 0.0580846968182262 0.953681163981632 1.0 1.0 3 P83916 1 +Septin cytoskeleton 0.3430518742900456 0.056093834305687 0.9552670557180438 1.0 1.0 3 Q16181,Q15019 2 +Endoplasmic reticulum exit site 0.3020625332186019 0.0531471953664601 0.9576146280982376 1.0 1.0 17 Q9HCU5,Q92734,Q96PC5,Q9NR31,P04439 5 +Xy body 0.3343430518742895 0.0519189131216593 0.9585933041073472 1.0 1.0 3 Q92922,Q12824 2 +Aryl hydrocarbon receptor complex 0.389856169568502 0.0458450820117031 0.9634337263148212 1.0 1.0 2 O00170 1 +Transcription factor tfiiic complex 0.3098484848484883 0.0345485821020661 0.9724397025347952 1.0 1.0 4 Q8WUA4,Q12789,Q9UKN8 3 +Rna polymerase iii transcription regulator complex 0.3098484848484883 0.0345485821020661 0.9724397025347952 1.0 1.0 4 Q8WUA4,Q12789,Q9UKN8 3 +Axonal growth cone 0.3205759757483911 0.0276127657462876 0.9779709999551748 1.0 1.0 5 Q02790,P08238,Q7L576,P07900 4 +Leading edge membrane 0.3179098886575426 0.0238585191435988 0.980965461783821 1.0 1.0 34 Q06481,P51790 2 diff --git a/msigdb_gocc/selections.json b/msigdb_gocc/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..7eafaedb3d1ef54f9798bfbb1fa0855ec5d70395 --- /dev/null +++ b/msigdb_gocc/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["90s preribosome", "9plus0 non motile cilium", "9plus2 motile cilium", "A band", "Acrosomal membrane", "Acrosomal vesicle", "Actin based cell projection", "Actin cytoskeleton", "Actin filament", "Actin filament bundle", "Actomyosin", "Adherens junction", "Aggresome", "Alpha dna polymerase primase complex", "Alveolar lamellar body", "Aminoacyl trna synthetase multienzyme complex", "Ampa glutamate receptor complex", "Amphisome", "Amphisome membrane", "Anaphase promoting complex", "Anchored component of membrane", "Anchored component of plasma membrane", "Anchored component of postsynaptic membrane", "Anchored component of synaptic membrane", "Anchored component of synaptic vesicle membrane", "Anchoring junction", "Annulate lamellae", "Ap 1 adaptor complex", "Ap 3 adaptor complex", "Ap type membrane coat adaptor complex", "Apical dendrite", "Apical junction complex", "Apical part of cell", "Apical plasma membrane", "Apicolateral plasma membrane", "Arp2 3 protein complex", "Aryl hydrocarbon receptor complex", "Aster", "Astrocyte end foot", "Astrocyte projection", "Atac complex", "Atpase complex", "Atpase dependent transmembrane transport complex", "Autolysosome", "Autophagosome", "Autophagosome membrane", "Axolemma", "Axon", "Axon cytoplasm", "Axon hillock", "Axonal growth cone", "Azurophil granule", "Azurophil granule lumen", "Azurophil granule membrane", "B wich complex", "Barr body", "Basal cortex", "Basal dendrite", "Basal part of cell", "Basement membrane", "Basolateral plasma membrane", "Bcl 2 family protein complex", "Beta catenin destruction complex", "Beta catenin tcf complex", "Bleb", "Blood microparticle", "Box c d rnp complex", "Box h aca rnp complex", "Box h aca snornp complex", "Box h aca telomerase rnp complex", "Brca1 c complex", "Brisc complex", "Brush border", "Brush border membrane", "Cajal body", "Calcium and calmodulin dependent protein kinase complex", "Calcium channel complex", "Camp dependent protein kinase complex", "Carboxy terminal domain protein kinase complex", "Caspase complex", "Catalytic complex", "Catalytic step 1 spliceosome", "Catalytic step 2 spliceosome", "Catenin complex", "Cation channel complex", "Cation transporting atpase complex", "Caveola", "Ccaat binding factor complex", "Ccr4 not complex", "Ccr4 not core complex", "Cd40 receptor complex", "Cd95 death inducing signaling complex", "Cdc73 paf1 complex", "Cell body", "Cell body membrane", "Cell cell contact zone", "Cell cell junction", "Cell cortex", "Cell cortex region", "Cell division site", "Cell leading edge", "Cell pole", "Cell projection membrane", "Cell substrate junction", "Cell surface", "Cell tip", "Cell trailing edge", "Central element", "Centriolar satellite", "Centriolar subdistal appendage", "Centriole", "Centrosome", "Cerebellar mossy fiber", "Chaperone complex", "Chaperonin containing t complex", "Chitosome", "Chloride channel complex", "Cholinergic synapse", "Chromaffin granule", "Chromaffin granule membrane", "Chromatin", "Chromatin silencing complex", "Chromatoid body", "Chromocenter", "Chromosomal region", "Chromosome", "Chromosome centromeric core domain", "Chromosome centromeric region", "Chromosome passenger complex", "Chromosome telomeric region", "Chromosome telomeric repeat region", "Cia complex", "Ciliary basal body", "Ciliary base", "Ciliary membrane", "Ciliary plasm", "Ciliary rootlet", "Ciliary tip", "Ciliary transition fiber", "Ciliary transition zone", "Cilium", "Cis golgi network", "Cis golgi network membrane", "Clathrin adaptor complex", "Clathrin coat", "Clathrin coat of coated pit", "Clathrin coat of endocytic vesicle", "Clathrin coated endocytic vesicle", "Clathrin coated endocytic vesicle membrane", "Clathrin coated pit", "Clathrin coated vesicle", "Clathrin coated vesicle membrane", "Clathrin complex", "Clathrin sculpted gamma aminobutyric acid transport vesicle", "Clathrin sculpted vesicle", "Clathrin vesicle coat", "Cleavage furrow", "Cluster of actin based cell projections", "Coated vesicle", "Coated vesicle membrane", "Cohesin complex", "Collagen containing extracellular matrix", "Collagen trimer", "Commitment complex", "Compact myelin", "Condensed chromosome", "Condensed chromosome centromeric region", "Condensed nuclear chromosome", "Condensin complex", "Contractile fiber", "Contractile ring", "Cop9 signalosome", "Copi coated vesicle", "Copi coated vesicle membrane", "Copi vesicle coat", "Copii coated er to golgi transport vesicle", "Copii vesicle coat", "Core mediator complex", "Cornified envelope", "Cortical actin cytoskeleton", "Cortical cytoskeleton", "Cortical endoplasmic reticulum", "Cortical granule", "Costamere", "Crd mediated mrna stability complex", "Ctf18 rfc like complex", "Cul2 ring ubiquitin ligase complex", "Cul3 ring ubiquitin ligase complex", "Cul4 ring e3 ubiquitin ligase complex", "Cul4a ring e3 ubiquitin ligase complex", "Cul4b ring e3 ubiquitin ligase complex", "Cul5 ring ubiquitin ligase complex", "Cullin ring ubiquitin ligase complex", "Cuticular plate", "Cyclin a2 cdk2 complex", "Cyclin dependent protein kinase holoenzyme complex", "Cytochrome complex", "Cytolytic granule", "Cytoplasmic dynein complex", "Cytoplasmic exosome rnase complex", "Cytoplasmic microtubule", "Cytoplasmic region", "Cytoplasmic side of endoplasmic reticulum membrane", "Cytoplasmic side of endosome membrane", "Cytoplasmic side of lysosomal membrane", "Cytoplasmic side of membrane", "Cytoplasmic stress granule", "Cytoplasmic ubiquitin ligase complex", "Cytosolic large ribosomal subunit", "Cytosolic region", "Cytosolic ribosome", "Cytosolic small ribosomal subunit", "Death inducing signaling complex", "Dendrite cytoplasm", "Dendrite membrane", "Dendrite terminus", "Dendritic growth cone", "Dendritic shaft", "Dendritic spine membrane", "Dendritic tree", "Dense body", "Dentate gyrus mossy fiber", "Derlin 1 retrotranslocation complex", "Desmosome", "Deuterosome", "Dihydrolipoyl dehydrogenase complex", "Distal axon", "Dna packaging complex", "Dna polymerase complex", "Dna repair complex", "Dna replication factor c complex", "Dna replication preinitiation complex", "Dopaminergic synapse", "Dynactin complex", "Dynein axonemal particle", "Dynein complex", "Dystrophin associated glycoprotein complex", "Early endosome", "Early endosome lumen", "Early endosome membrane", "Early phagosome", "Ekc keops complex", "Elongator holoenzyme complex", "Elongin complex", "Emc complex", "Endocytic vesicle", "Endocytic vesicle lumen", "Endocytic vesicle membrane", "Endolysosome", "Endolysosome lumen", "Endolysosome membrane", "Endopeptidase complex", "Endoplasmic reticulum", "Endoplasmic reticulum chaperone complex", "Endoplasmic reticulum exit site", "Endoplasmic reticulum golgi intermediate compartment", "Endoplasmic reticulum golgi intermediate compartment membrane", "Endoplasmic reticulum lumen", "Endoplasmic reticulum palmitoyltransferase complex", "Endoplasmic reticulum plasma membrane contact site", "Endoplasmic reticulum protein containing complex", "Endoplasmic reticulum quality control compartment", "Endoplasmic reticulum tubular network", "Endoplasmic reticulum tubular network membrane", "Endoribonuclease complex", "Endosome", "Endosome lumen", "Endosome membrane", "Envelope", "Enzyme activator complex", "Epsilon dna polymerase complex", "Equatorial microtubule organizing center", "Er membrane insertion complex", "Er to golgi transport vesicle membrane", "Er ubiquitin ligase complex", "Esc e z complex", "Escrt complex", "Escrt i complex", "Escrt iii complex", "Euchromatin", "Eukaryotic translation initiation factor 2 complex", "Eukaryotic translation initiation factor 2b complex", "Eukaryotic translation initiation factor 3 complex", "Eukaryotic translation initiation factor 3 complex eif3m", "Eukaryotic translation initiation factor 4f complex", "Excitatory synapse", "Exocyst", "Exocytic vesicle", "Exon exon junction complex", "Exoribonuclease complex", "External encapsulating structure", "External side of apical plasma membrane", "External side of plasma membrane", "Extrinsic component of cytoplasmic side of plasma membrane", "Extrinsic component of endoplasmic reticulum membrane", "Extrinsic component of endosome membrane", "Extrinsic component of external side of plasma membrane", "Extrinsic component of membrane", "Extrinsic component of mitochondrial inner membrane", "Extrinsic component of organelle membrane", "Extrinsic component of plasma membrane", "Extrinsic component of postsynaptic membrane", "Extrinsic component of postsynaptic specialization membrane", "Extrinsic component of synaptic membrane", "F actin capping protein complex", "Fascia adherens", "Female germ cell nucleus", "Female pronucleus", "Fibrillar center", "Ficolin 1 rich granule", "Ficolin 1 rich granule lumen", "Ficolin 1 rich granule membrane", "Filamentous actin", "Filopodium", "Filopodium membrane", "Filopodium tip", "Filtration diaphragm", "Flemming body", "Flotillin complex", "Gaba ergic synapse", "Gamma secretase complex", "Gamma tubulin complex", "Gap junction", "Gator2 complex", "Gemini of coiled bodies", "Germ cell nucleus", "Glial cell projection", "Glutamatergic synapse", "Glycinergic synapse", "Glycogen granule", "Glycoprotein complex", "Golgi apparatus", "Golgi apparatus subcompartment", "Golgi associated vesicle", "Golgi associated vesicle membrane", "Golgi cis cisterna", "Golgi cisterna", "Golgi cisterna membrane", "Golgi lumen", "Golgi medial cisterna", "Golgi membrane", "Golgi stack", "Golgi transport complex", "Gpi anchor transamidase complex", "Granular component", "Growth cone membrane", "Gtpase complex", "Guanyl nucleotide exchange factor complex", "H3 histone acetyltransferase complex", "H4 h2a histone acetyltransferase complex", "H4 histone acetyltransferase complex", "Haus complex", "Hemidesmosome", "Hemoglobin complex", "Heterochromatin", "Hfe transferrin receptor complex", "High density lipoprotein particle", "Hippocampal mossy fiber", "Hippocampal mossy fiber to ca3 synapse", "Histone deacetylase complex", "Histone methyltransferase complex", "Histone pre mrna 3 end processing complex", "Hops complex", "Host cellular component", "Hrd1p ubiquitin ligase erad l complex", "Hulc complex", "I band", "Ikappab kinase complex", "Immunological synapse", "Inclusion body", "Inflammasome complex", "Inhibitory synapse", "Inner mitochondrial membrane protein complex", "Ino80 complex", "Ino80 type complex", "Insulin responsive compartment", "Integral component of cytoplasmic side of endoplasmic reticulum membrane", "Integral component of lysosomal membrane", "Integral component of presynaptic active zone membrane", "Integral component of synaptic vesicle membrane", "Integrator complex", "Integrin complex", "Intercalated disc", "Intercellular bridge", "Intercellular canaliculus", "Intermediate filament", "Intermediate filament cytoskeleton", "Intracellular protein containing complex", "Intraciliary transport particle", "Intraciliary transport particle b", "Intrinsic component of endoplasmic reticulum membrane", "Intrinsic component of golgi membrane", "Intrinsic component of mitochondrial inner membrane", "Intrinsic component of mitochondrial membrane", "Intrinsic component of mitochondrial outer membrane", "Intrinsic component of nuclear inner membrane", "Intrinsic component of organelle membrane", "Intrinsic component of peroxisomal membrane", "Intrinsic component of plasma membrane", "Intrinsic component of postsynaptic density membrane", "Intrinsic component of postsynaptic membrane", "Intrinsic component of postsynaptic specialization membrane", "Intrinsic component of presynaptic active zone membrane", "Intrinsic component of presynaptic membrane", "Intrinsic component of synaptic membrane", "Intrinsic component of synaptic vesicle membrane", "Intrinsic component of vacuolar membrane", "Ion channel complex", "Iron sulfur cluster assembly complex", "Iswi type complex", "Juxtaparanode region of axon", "Keratin filament", "Kinesin complex", "Kinetochore microtubule", "Lamellar body", "Lamellipodium", "Lamellipodium membrane", "Lamin filament", "Large ribosomal subunit", "Late endosome", "Late endosome membrane", "Lateral element", "Lateral part of cell", "Lateral plasma membrane", "Leading edge membrane", "Lewy body", "Lipid droplet", "Lipopolysaccharide receptor complex", "Low density lipoprotein particle", "Lsm1 7 pat1 complex", "Lsm2 8 complex", "Lumenal side of endoplasmic reticulum membrane", "Lumenal side of membrane", "Lysosomal lumen", "M band", "Magnesium dependent protein serine threonine phosphatase complex", "Main axon", "Male germ cell nucleus", "Male pronucleus", "Manchette", "Mcm complex", "Mcrd mediated mrna stability complex", "Mediator complex", "Meiotic cohesin complex", "Meiotic spindle", "Membrane coat", "Membrane microdomain", "Membrane protein complex", "Messenger ribonucleoprotein complex", "Methylosome", "Methyltransferase complex", "Mhc class i peptide loading complex", "Mhc class i protein complex", "Mhc protein complex", "Mib complex", "Micos complex", "Microbody", "Microbody lumen", "Microbody membrane", "Microtubule", "Microtubule associated complex", "Microtubule bundle", "Microtubule cytoskeleton", "Microtubule end", "Microtubule minus end", "Microtubule organizing center", "Microtubule organizing center attachment site", "Microtubule plus end", "Microvillus", "Microvillus membrane", "Midbody", "Mismatch repair complex", "Mitochondria associated endoplasmic reticulum membrane", "Mitochondrial alpha ketoglutarate dehydrogenase complex", "Mitochondrial crista", "Mitochondrial envelope", "Mitochondrial intermembrane space protein transporter complex", "Mitochondrial large ribosomal subunit", "Mitochondrial matrix", "Mitochondrial permeability transition pore complex", "Mitochondrial protein containing complex", "Mitochondrial proton transporting atp synthase complex coupling factor f o", "Mitochondrial pyruvate dehydrogenase complex", "Mitochondrial small ribosomal subunit", "Mitochondrial tricarboxylic acid cycle enzyme complex", "Mitochondrion", "Mitotic cohesin complex", "Mitotic spindle", "Mitotic spindle astral microtubule", "Mitotic spindle microtubule", "Mitotic spindle midzone", "Mitotic spindle pole", "Mll1 2 complex", "Mll3 4 complex", "Mmxd complex", "Mon1 ccz1 complex", "Motile cilium", "Mpp7 dlg1 lin7 complex", "Mrna cleavage and polyadenylation specificity factor complex", "Mrna cleavage factor complex", "Mrna editing complex", "Multimeric ribonuclease p complex", "Multivesicular body", "Multivesicular body membrane", "Myelin sheath", "Myelin sheath abaxonal region", "Myelin sheath adaxonal region", "Myofilament", "Myosin complex", "Myosin filament", "Myosin ii complex", "N terminal protein acetyltransferase complex", "Nadh dehydrogenase complex", "Nascent polypeptide associated complex", "Nata complex", "Nbaf complex", "Neurofibrillary tangle", "Neurofilament", "Neuromuscular junction", "Neuron projection", "Neuron projection cytoplasm", "Neuron projection membrane", "Neuron projection terminus", "Neuron spine", "Neuron to neuron synapse", "Neuronal ribonucleoprotein granule", "Neurotransmitter receptor complex", "Nlrp3 inflammasome complex", "Nls dependent protein nuclear import complex", "Non motile cilium", "Nonhomologous end joining complex", "Npbaf complex", "Nsl complex", "Nuclear body", "Nuclear chromosome", "Nuclear cyclin dependent protein kinase holoenzyme complex", "Nuclear envelope", "Nuclear envelope lumen", "Nuclear exosome rnase complex", "Nuclear inclusion body", "Nuclear inner membrane", "Nuclear lamina", "Nuclear membrane", "Nuclear outer membrane", "Nuclear outer membrane endoplasmic reticulum membrane network", "Nuclear periphery", "Nuclear pore", "Nuclear pore central transport channel", "Nuclear pore nuclear basket", "Nuclear pore outer ring", "Nuclear protein containing complex", "Nuclear replication fork", "Nuclear rna export factor complex", "Nuclear speck", "Nuclear stress granule", "Nuclear ubiquitin ligase complex", "Nucleocytoplasmic transport complex", "Nucleoid", "Nucleolar ribonuclease p complex", "Nucleolus", "Nucleotide activated protein kinase complex", "Nucleotide excision repair complex", "Nurd complex", "Nurf complex", "Oligosaccharyltransferase complex", "Organellar ribosome", "Organelle envelope lumen", "Organelle inner membrane", "Organelle membrane contact site", "Organelle subcompartment", "Origin recognition complex", "Outer dense fiber", "Outer kinetochore", "Outer membrane", "Outer mitochondrial membrane protein complex", "Oxidoreductase complex", "Oxoglutarate dehydrogenase complex", "P body", "Palmitoyltransferase complex", "Pam complex tim23 associated import motor", "Parallel fiber to purkinje cell synapse", "Paranodal junction", "Paraspeckles", "Pcg protein complex", "Peptidase complex", "Peptidase inhibitor complex", "Pericentric heterochromatin", "Pericentriolar material", "Perikaryon", "Perinuclear endoplasmic reticulum", "Perinuclear region of cytoplasm", "Perinucleolar compartment", "Phagocytic cup", "Phagocytic vesicle", "Phagocytic vesicle membrane", "Phagolysosome", "Phagophore assembly site", "Phagophore assembly site membrane", "Phosphatase complex", "Phosphatidylinositol 3 kinase complex", "Phosphatidylinositol 3 kinase complex class iii", "Phosphorylase kinase complex", "Photoreceptor connecting cilium", "Photoreceptor inner segment", "Photoreceptor outer segment", "Photoreceptor ribbon synapse", "Pi body", "Picln sm protein complex", "Pigment granule", "Pinosome", "Pip body", "Plasma membrane protein complex", "Plasma membrane raft", "Plasma membrane region", "Plasma membrane signaling receptor complex", "Platelet alpha granule", "Platelet alpha granule lumen", "Platelet alpha granule membrane", "Platelet dense granule", "Platelet dense granule lumen", "Platelet dense tubular network", "Platelet dense tubular network membrane", "Pml body", "Podosome", "Polar microtubule", "Pole plasm", "Polymeric cytoskeletal fiber", "Polysomal ribosome", "Polysome", "Pore complex", "Post mrna release spliceosomal complex", "Postsynapse", "Postsynaptic cytoskeleton", "Postsynaptic cytosol", "Postsynaptic density intracellular component", "Postsynaptic density membrane", "Postsynaptic endosome", "Postsynaptic membrane", "Postsynaptic recycling endosome", "Postsynaptic specialization intracellular component", "Postsynaptic specialization membrane", "Potassium channel complex", "Prc1 complex", "Pre snornp complex", "Precatalytic spliceosome", "Prefoldin complex", "Preribosome", "Preribosome large subunit precursor", "Preribosome small subunit precursor", "Prespliceosome", "Presynapse", "Presynaptic active zone", "Presynaptic active zone cytoplasmic component", "Presynaptic active zone membrane", "Presynaptic cytoskeleton", "Presynaptic cytosol", "Presynaptic endocytic zone", "Presynaptic membrane", "Procentriole replication complex", "Pronucleus", "Protease inhibitor complex", "Proteasome accessory complex", "Proteasome complex", "Proteasome core complex", "Proteasome core complex alpha subunit complex", "Proteasome core complex beta subunit complex", "Proteasome regulatory particle", "Proteasome regulatory particle base subcomplex", "Proteasome regulatory particle lid subcomplex", "Protein acetyltransferase complex", "Protein complex involved in cell adhesion", "Protein dna complex", "Protein kinase complex", "Protein lipid complex", "Protein phosphatase 4 complex", "Protein phosphatase type 1 complex", "Protein phosphatase type 2a complex", "Proton transporting atp synthase complex", "Proton transporting atp synthase complex catalytic core f 1", "Proton transporting atp synthase complex coupling factor f o", "Proton transporting two sector atpase complex", "Proton transporting two sector atpase complex catalytic domain", "Proton transporting two sector atpase complex proton transporting domain", "Proton transporting v type atpase complex", "Proton transporting v type atpase v0 domain", "Proton transporting v type atpase v1 domain", "Proximal dendrite", "Prp19 complex", "Pseudopodium", "Ptw pp1 phosphatase complex", "Pwp2p containing subcomplex of 90s preribosome", "R2tp complex", "Ragulator complex", "Rdna heterochromatin", "Receptor complex", "Recycling endosome", "Recycling endosome membrane", "Replication fork", "Replisome", "Respirasome", "Respiratory chain complex iii", "Respiratory chain complex iv", "Retromer complex", "Ribbon synapse", "Ribonuclease mrp complex", "Ribonuclease p complex", "Ribonucleoprotein complex", "Ribonucleoprotein granule", "Ribose phosphate diphosphokinase complex", "Ribosomal subunit", "Ribosome", "Risc loading complex", "Rna cap binding complex", "Rna polymerase complex", "Rna polymerase i complex", "Rna polymerase ii core complex", "Rna polymerase ii holoenzyme", "Rna polymerase ii transcription regulator complex", "Rna polymerase ii transcription repressor complex", "Rna polymerase iii complex", "Rna polymerase iii transcription regulator complex", "Rnai effector complex", "Rough endoplasmic reticulum", "Rough endoplasmic reticulum membrane", "Rpap3 r2tp prefoldin like complex", "Ruffle", "Ruffle membrane", "Saga complex", "Saga type complex", "Sarcolemma", "Sarcoplasm", "Sarcoplasmic reticulum lumen", "Sarcoplasmic reticulum membrane", "Scar complex", "Scf ubiquitin ligase complex", "Schaffer collateral ca1 synapse", "Sec61 translocon complex", "Secondary lysosome", "Secretory granule", "Secretory granule membrane", "Secretory vesicle", "Seh1 associated complex", "Semaphorin receptor complex", "Septin cytoskeleton", "Serine protease inhibitor complex", "Set1c compass complex", "Sex chromatin", "Sex chromosome", "Shelterin complex", "Side of membrane", "Signal peptidase complex", "Signal recognition particle", "Sin3 complex", "Sin3 type complex", "Site of dna damage", "Site of double strand break", "Site of polarized growth", "Sm like protein family complex", "Small ribosomal subunit", "Small subunit processome", "Smc5 smc6 complex", "Smn complex", "Smn sm protein complex", "Smooth endoplasmic reticulum", "Smooth endoplasmic reticulum membrane", "Snare complex", "Sno s rna containing ribonucleoprotein complex", "Sodium potassium exchanging atpase complex", "Somatodendritic compartment", "Sorting endosome", "Spanning component of membrane", "Specific granule", "Specific granule lumen", "Specific granule membrane", "Spectrin", "Spectrin associated cytoskeleton", "Sperm annulus", "Sperm connecting piece", "Sperm fibrous sheath", "Sperm head", "Sperm head plasma membrane", "Sperm midpiece", "Sperm plasma membrane", "Sperm principal piece", "Spermatoproteasome complex", "Spindle", "Spindle microtubule", "Spindle midzone", "Spindle pole", "Spindle pole centrosome", "Spliceosomal complex", "Spliceosomal snrnp complex", "Spliceosomal tri snrnp complex", "Stereocilium bundle", "Stereocilium membrane", "Stereocilium tip", "Striated muscle thin filament", "Sumo ligase complex", "Supramolecular complex", "Supramolecular polymer", "Swi snf complex", "Swr1 complex", "Synapse", "Synaptic membrane", "Synaptic vesicle membrane", "Synaptonemal structure", "T tubule", "Telomerase holoenzyme complex", "Terminal bouton", "Tertiary granule", "Tertiary granule lumen", "Tertiary granule membrane", "Tetraspanin enriched microdomain", "Tho complex", "Tight junction", "Tim22 mitochondrial import inner membrane insertion complex", "Tim23 mitochondrial import inner membrane translocase complex", "Tor complex", "Torc1 complex", "Trans golgi network", "Trans golgi network membrane", "Trans golgi network transport vesicle", "Trans golgi network transport vesicle membrane", "Transcription elongation factor complex", "Transcription export complex", "Transcription export complex 2", "Transcription factor tfiid complex", "Transcription factor tfiih holo complex", "Transcription factor tfiiic complex", "Transcription regulator complex", "Transcription repressor complex", "Transferase complex", "Transferase complex transferring phosphorus containing groups", "Translation preinitiation complex", "Translocon complex", "Transport vesicle", "Transport vesicle membrane", "Transporter complex", "Trapp complex", "Tricarboxylic acid cycle enzyme complex", "Triglyceride rich plasma lipoprotein particle", "Trna methyltransferase complex", "Trna splicing ligase complex", "Tubular endosome", "U1 snrnp", "U12 type spliceosomal complex", "U2 snrnp", "U2 type catalytic step 2 spliceosome", "U2 type spliceosomal complex", "U2af complex", "U4 snrnp", "U5 snrnp", "U6 snrnp", "U7 snrnp", "Ubiquinone biosynthesis complex", "Ubiquitin conjugating enzyme complex", "Ubiquitin ligase complex", "Unconventional myosin complex", "Uniplex complex", "Vacuolar lumen", "Vacuolar membrane", "Vacuolar proton transporting v type atpase v0 domain", "Vacuole", "Varicosity", "Vcp npl4 ufd1 aaa atpase complex", "Vesicle coat", "Vesicle lumen", "Vesicle membrane", "Vesicle tethering complex", "Voltage gated calcium channel complex", "Wash complex", "Weibel palade body", "Wnt signalosome", "X chromosome", "Xy body", "Zona pellucida receptor complex", "Zonula adherens", "Zymogen granule", "Zymogen granule membrane"], "available_proteins": ["AAAS", "AAMP", "AARS", "AARS2", "AATF", "ABCB1", "ABCB7", "ABCD3", "ABCE1", "ABCF1", "ABHD10", "ABHD12", "ABHD14B", "ABHD6", "ABI1", "ABRAXAS2", "ACAA2", "ACACA", "ACACB", "ACAD9", "ACADM", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACIN1", "ACLY", "ACO2", "ACOT13", "ACOT7", "ACOT9", "ACOX1", "ACOX3", "ACP1", "ACP2", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN2", "ACTN4", "ACTR1A", "ACTR2", "ACTR3", "ADAR", "ADD1", "ADD3", "ADH5", "ADNP", "ADPGK", "ADPRHL2", "ADRM1", "ADSS", "AFDN", "AFG3L2", "AGK", "AGL", "AGPAT1", "AGPS", "AHCY", "AHCYL1", "AHNAK", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AK3", "AKAP1", "AKAP12", "AKAP13", "AKAP17A", "AKAP8", "AKAP8L", "AKR1A1", "AKR7A2", "AKT2", "ALDH18A1", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDOA", "ALDOC", "ALG1", "ALG12", "ALKBH5", "AMOT", "ANAPC1", "ANAPC10", "ANAPC5", "ANAPC7", "ANKLE2", "ANKRD17", "ANLN", "ANP32A", "ANP32B", "ANXA1", "ANXA11", "ANXA2", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP1M1", "AP1S2", "AP2A1", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "APEH", "APEX1", "APEX2", "API5", "APLP2", "APMAP", "APOL2", "APOO", "APOOL", "APP", "APRT", "AQR", "ARCN1", "ARF4", "ARFGAP1", "ARFGAP2", "ARFIP1", "ARFIP2", "ARHGAP17", "ARHGDIA", "ARHGEF2", "ARID1A", "ARIH1", "ARIH2", "ARL1", "ARL2", "ARL3", "ARL6IP1", "ARL6IP5", "ARMC10", "ARMCX3", "ARPC1A", "ARPC2", "ARPC3", "ARPC4", "ARSA", "ARV1", "ASAH1", "ASCC2", "ASCC3", "ASH2L", "ASNA1", "ASPH", "ASPSCR1", "ASRGL1", "ATAD1", "ATAD3A", "ATAD3B", "ATG3", "ATL2", "ATP13A1", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2C1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6", "ATP6AP1", "ATP6AP2", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1D", "ATP6V1E1", "ATP6V1G1", "ATP6V1H", "ATP7B", "ATPAF1", "ATPIF1", "ATXN10", "ATXN2L", "AUP1", "AURKA", "B4GAT1", "BAG3", "BAG5", "BAG6", "BAIAP2", "BANF1", "BAZ1A", "BAZ1B", "BCAP31", "BCAS3", "BCCIP", "BCLAF1", "BCS1L", "BICD2", "BIRC6", "BMS1", "BOLA2*", "BOP1", "BPTF", "BRAP", "BRD1", "BRD2", "BRIX1", "BSG", "BTF3", "BUB1B", "BUB3", "BUD23", "BUD31", "BYSL", "C12orf73", "C17orf75", "C19orf70", "C1QBP", "C1orf35", "CAB39", "CACYBP", "CAD", "CALCOCO1", "CALD1", "CALM3", "CALR", "CALU", "CAMK1", "CAMK2G", "CAND1", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPNS1", "CAPRIN1", "CAPZA1", "CAPZA2", "CAPZB", "CASK", "CAST", "CBL", "CBX1", "CBX2", "CBX3", "CBX5", "CCAR1", "CCAR2", "CCDC124", "CCDC22", "CCDC47", "CCDC86", "CCNB1", "CCNB2", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2AP", "CDC20", "CDC23", "CDC25C", "CDC27", "CDC34", "CDC37", "CDC40", "CDC42", "CDC5L", "CDC73", "CDCA8", "CDK1", "CDK2", "CDK4", "CDK5", "CDK5RAP3", "CDK6", "CDKN2AIP", "CDX2", "CEBPZ", "CENPF", "CENPP", "CEP55", "CEPT1", "CERS2", "CETN2", "CFAP20", "CFL1", "CFL2", "CHAF1A", "CHAF1B", "CHAMP1", "CHCHD3", "CHD4", "CHERP", "CHID1", "CHM", "CHMP2A", "CHMP2B", "CHMP7", "CHORDC1", "CHRAC1", "CHST14", "CHUK", "CIAPIN1", "CIRBP", "CISD2", "CKAP2", "CKAP4", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLASP2", "CLCC1", "CLCN3", "CLCN7", "CLGN", "CLIC1", "CLIC4", "CLINT1", "CLIP1", "CLN5", "CLNS1A", "CLPB", "CLPP", "CLPTM1", "CLPX", "CLTC", "CMPK1", "CNN2", "CNN3", "CNNM4", "CNOT1", "CNOT2", "CNOT3", "CNOT4", "CNOT7", "CNOT9", "CNP", "CNPY2", "COIL", "COL4A3BP", "COLEC12", "COLGALT1", "COMT", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS7A", "COPS7B", "COPS8", "COPZ1", "COQ3", "COQ8A", "COQ9", "CORO1A", "CORO1C", "CORO7", "COTL1", "COX2", "COX4I1", "COX5A", "COX6C", "COX7A2", "CPNE1", "CPNE3", "CPOX", "CPSF1", "CPSF3", "CPSF6", "CPSF7", "CPT2", "CRK", "CRKL", "CRNKL1", "CRTAP", "CS", "CSDE1", "CSE1L", "CSGALNACT2", "CSK", "CSNK1A1", "CSNK2A1", "CSNK2A2", "CSNK2B", "CSTB", "CSTF1", "CSTF2", "CTBP1", "CTBP2", "CTBS", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTSA", "CTSB", "CTSC", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CWF19L1", "CXADR", "CXorf56", "CXorf57", "CYB5B", "CYB5R1", "CYB5R3", "CYC1", "CYFIP1", "CYP51A1", "DAP3", "DARS", "DARS2", "DAZAP1", "DBN1", "DBNL", "DCAF1", "DCAF7", "DCPS", "DCTN1", "DCTN2", "DCTN3", "DCTN4", "DCTPP1", "DCUN1D4", "DCXR", "DDB1", "DDI2", "DDOST", "DDRGK1", "DDX1", "DDX17", "DDX18", "DDX20", "DDX21", "DDX23", "DDX24", "DDX27", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX5", "DDX50", "DDX51", "DDX52", "DDX54", "DDX56", "DDX6", "DEK", "DERL1", "DFFA", "DHCR24", "DHCR7", "DHFR", "DHRS1", "DHRS7", "DHX15", "DHX16", "DHX29", "DHX30", "DHX36", "DHX37", "DHX8", "DHX9", "DIABLO", "DIAPH1", "DIAPH2", "DIDO1", "DIEXF", "DIMT1", "DIS3", "DKC1", "DLAT", "DLD", "DLST", "DNA2", "DNAAF5", "DNAJA1", "DNAJA3", "DNAJB1", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC2", "DNAJC3", "DNAJC8", "DNAJC9", "DNASE2", "DNM1L", "DNM2", "DNMT1", "DNTTIP2", "DOCK7", "DPM1", "DPP9", "DPY30", "DPYSL2", "DPYSL5", "DR1", "DRG1", "DSC1", "DSC3", "DSG2", "DSP", "DST", "DSTN", "DTYMK", "DUSP3", "DUT", "DYNC1H1", "DYNC1LI1", "DYNC1LI2", "DYNC2H1", "DYNLL1", "EBNA1BP2", "ECE1", "ECH1", "ECHS1", "ECI1", "ECI2", "ECSIT", "EDC3", "EDC4", "EDF1", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EFHD1", "EFL1", "EFTUD2", "EHD1", "EHD4", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2D", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A3", "EIF4B", "EIF4E", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5A", "ELAC2", "ELAVL1", "ELOA", "ELOB", "ELOC", "ELP1", "ELP2", "ELP3", "ELP4", "EMC1", "EMC2", "EMC7", "EMD", "EMG1", "ENAH", "ENO1", "ENO2", "EPB41", "EPB41L2", "EPB41L5", "EPDR1", "EPHA7", "EPHX1", "EPHX2", "EPPK1", "EPRS", "EPS15", "EPS15L1", "ERAL1", "ERAP1", "ERCC2", "ERG28", "ERGIC3", "ERH", "ERI1", "ERLIN1", "ERLIN2", "ERMP1", "ERO1A", "ERP29", "ESD", "ESF1", "ESYT1", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXO1", "EXOC2", "EXOC3", "EXOC5", "EXOC7", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "EZR", "FAF1", "FAF2", "FAHD1", "FAM129B", "FAM162A", "FAM208A", "FAM49B", "FAM8A1", "FAM98B", "FANCI", "FAR1", "FARSA", "FARSB", "FASN", "FBL", "FBXO22", "FBXO7", "FCGRT", "FDFT1", "FECH", "FEN1", "FGFR1OP", "FH", "FHOD1", "FIP1L1", "FIS1", "FKBP10", "FKBP14", "FKBP1A", "FKBP4", "FKBP7", "FKBP8", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FMR1", "FNTB", "FOXRED1", "FRG1", "FSCN1", "FTO", "FTSJ3", "FUCA1", "FUCA2", "FUNDC2", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GADD45GIP1", "GAK", "GALNT1", "GALNT2", "GALNT7", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GATAD2A", "GBA", "GBF1", "GCAT", "GCDH", "GCFC2", "GCLC", "GCLM", "GCN1", "GDI1", "GDI2", "GDPD1", "GEMIN4", "GEMIN5", "GET4", "GFM1", "GGCX", "GGH", "GHDC", "GHITM", "GIGYF2", "GINS3", "GINS4", "GLA", "GLB1", "GLDC", "GLG1", "GLMN", "GLOD4", "GLRX3", "GLRX5", "GLS", "GLUD1", "GLYR1", "GM2A", "GNA13", "GNAI1", "GNAI2", "GNAI3", "GNL2", "GNL3", "GNL3L", "GNPAT", "GNS", "GOLGA3", "GOLGB1", "GOLIM4", "GOLT1B", "GOPC", "GORASP2", "GOT2", "GPAM", "GPATCH11", "GPATCH4", "GPD2", "GPI", "GPKOW", "GPR107", "GPR108", "GPS1", "GRB2", "GRHPR", "GRIPAP1", "GRPEL1", "GRSF1", "GRWD1", "GSK3B", "GSR", "GSTK1", "GSTM3", "GSTZ1", "GTF3C1", "GTF3C2", "GTF3C3", "GTF3C4", "GTPBP1", "GTPBP10", "GTPBP3", "GTPBP4", "GUF1", "GUSB", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACD3", "HACL1", "HADH", "HADHA", "HADHB", "HAT1", "HAUS3", "HAUS5", "HAUS8", "HCCS", "HCFC1", "HDAC2", "HDGF", "HDHD5", "HDLBP", "HEATR1", "HEBP2", "HECTD3", "HELLS", "HEXA", "HEXB", "HIBADH", "HIBCH", "HIF1AN", "HIGD2A", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HLTF", "HM13", "HMCES", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMGN2", "HMOX1", "HMOX2", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPM", "HNRNPR", "HNRNPU", "HP1BP3", "HPF1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSDL1", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA13", "HSPA14", "HSPA1B", "HSPA4", "HSPA8", "HSPA9", "HSPB1", "HSPD1", "HSPE1", "HSPH1", "HTATIP2", "HUWE1", "HYOU1", "IARS", "IARS2", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDI1", "IFT27", "IGF2BP1", "IGF2BP3", "IGF2R", "IK", "IKBIP", "ILF2", "ILF3", "ILVBL", "IMMT", "IMP4", "IMPACT", "IMPDH1", "IMPDH2", "INA", "INCENP", "INTS11", "INTS14", "INTS7", "INTS9", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "ISCU", "ISOC1", "IST1", "ITGB1", "ITM2C", "IVD", "JUP", "KARS", "KCTD12", "KCTD5", "KDELC2", "KDELR1", "KDM1A", "KDM1B", "KDM3B", "KDSR", "KHDRBS1", "KIAA0319L", "KIAA0368", "KIAA0391", "KIF11", "KIF15", "KIF18B", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF4A", "KIF5B", "KIF7", "KIFBP", "KIFC1", "KLC1", "KMT2A", "KNTC1", "KPNA1", "KPNA2", "KPNA3", "KPNB1", "KRI1", "KRR1", "KTN1", "LAMP1", "LAMTOR1", "LANCL2", "LAP3", "LARP1", "LARP4", "LARP4B", "LARS", "LARS2", "LAS1L", "LASP1", "LBR", "LCLAT1", "LDAH", "LDHA", "LDHB", "LEMD2", "LEMD3", "LETM1", "LGALS3", "LGALS3BP", "LGMN", "LIG1", "LIG3", "LIMA1", "LIPA", "LLGL1", "LMAN1", "LMAN2", "LMNA", "LMNB1", "LMNB2", "LNPEP", "LONP1", "LPCAT1", "LPCAT3", "LPGAT1", "LRBA", "LRPPRC", "LRRC59", "LRWD1", "LSM2", "LSM6", "LSM7", "LSS", "LTA4H", "LTV1", "LUC7L2", "LUC7L3", "LYAR", "LYPLA1", "M6PR", "MACF1", "MAD2L1", "MAGED2", "MAN2A1", "MAN2B1", "MANBA", "MANF", "MAP1B", "MAP1S", "MAP2K1", "MAP4", "MAPK1", "MAPRE1", "MAPRE2", "MARC1", "MARCKS", "MARS", "MAT2A", "MAT2B", "MATR3", "MAVS", "MBD3", "MBOAT7", "MCAT", "MCCC1", "MCCC2", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCU", "MDC1", "MDH1", "MDH2", "MDN1", "ME1", "MECP2", "MED1", "MED21", "MED23", "MED24", "MED25", "MED4", "MFN2", "MFSD10", "MGST2", "MGST3", "MIA2", "MICU1", "MID1", "MIF", "MINDY3", "MINPP1", "MIPEP", "MKI67", "MLEC", "MMGT1", "MMS19", "MOGS", "MORF4L1", "MORF4L2", "MOSPD2", "MOV10", "MPC2", "MPHOSPH10", "MPHOSPH6", "MPP6", "MPRIP", "MPST", "MPV17L2", "MRE11", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL14", "MRPL15", "MRPL19", "MRPL21", "MRPL28", "MRPL3", "MRPL37", "MRPL38", "MRPL39", "MRPL40", "MRPL44", "MRPL45", "MRPL46", "MRPL47", "MRPL48", "MRPL49", "MRPL50", "MRPL53", "MRPL9", "MRPS11", "MRPS2", "MRPS22", "MRPS23", "MRPS25", "MRPS27", "MRPS28", "MRPS30", "MRPS31", "MRPS33", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRPS9", "MRTO4", "MSH2", "MSH3", "MSH6", "MSI2", "MSN", "MSTO1", "MTA1", "MTA2", "MTBP", "MTCH1", "MTCH2", "MTDH", "MTHFD1", "MTHFD1L", "MTHFD2", "MTMR2", "MTMR6", "MTOR", "MTPAP", "MTPN", "MTX1", "MTX2", "MVK", "MYBBP1A", "MYCBP", "MYDGF", "MYG1", "MYH10", "MYH14", "MYH9", "MYL6", "MYO1B", "MYO1C", "MYO1D", "MYO6", "NAA15", "NAA25", "NAA40", "NAA50", "NAF1", "NAGLU", "NAMPT", "NAP1L1", "NAP1L4", "NAPA", "NAPG", "NASP", "NAT10", "NAXE", "NBN", "NCAPD2", "NCAPG", "NCAPH", "NCBP1", "NCDN", "NCKAP1", "NCKIPSD", "NCL", "NCLN", "NCOA5", "NCSTN", "NDC1", "NDUFA10", "NDUFA3", "NDUFA4", "NDUFA5", "NDUFA7", "NDUFA9", "NDUFAF4", "NDUFAF7", "NDUFB10", "NDUFB3", "NDUFB4", "NDUFB5", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS6", "NDUFS7", "NDUFV1", "NDUFV2", "NECAP1", "NECAP2", "NEFL", "NEFM", "NEK9", "NELFA", "NELFB", "NELFCD", "NELFE", "NENF", "NES", "NFU1", "NHLRC2", "NHP2", "NIFK", "NIPBL", "NKRF", "NLE1", "NLN", "NMD3", "NME1", "NME6", "NME7", "NMT1", "NNT", "NOB1", "NOC2L", "NOC3L", "NOC4L", "NOL10", "NOL11", "NOL6", "NOL7", "NOL9", "NOLC1", "NOM1", "NONO", "NOP14", "NOP2", "NOP53", "NOP56", "NOP58", "NOSIP", "NPC1", "NPC2", "NPLOC4", "NPM1", "NRDC", "NRP1", "NSA2", "NSD2", "NSDHL", "NSF", "NSFL1C", "NSUN2", "NSUN5", "NTHL1", "NUB1", "NUBP2", "NUCB1", "NUCB2", "NUCKS1", "NUDC", "NUDCD2", "NUDT1", "NUDT12", "NUDT21", "NUF2", "NUFIP2", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP160", "NUP188", "NUP205", "NUP210", "NUP214", "NUP37", "NUP43", "NUP50", "NUP54", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NUPL2", "NVL", "NXF1", "OAT", "OCIAD1", "OCLN", "OCRL", "OGDH", "OGT", "OLA1", "OPA1", "OPA3", "OSBP", "OSBPL8", "OSBPL9", "OSGEP", "OTULIN", "OXA1L", "OXSR1", "P3H1", "P3H4", "P4HA1", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PAF1", "PAFAH1B1", "PAFAH1B2", "PAFAH1B3", "PAK1", "PAK1IP1", "PAK2", "PARK7", "PARN", "PARP1", "PATL1", "PBRM1", "PC", "PCBP1", "PCBP2", "PCCA", "PCK2", "PCLAF", "PCM1", "PCNA", "PCNP", "PCYOX1", "PDAP1", "PDCD11", "PDCD6", "PDCD6IP", "PDCL3", "PDE12", "PDE6D", "PDHA1", "PDHB", "PDIA3", "PDIA4", "PDIA6", "PDK1", "PDK3", "PDLIM1", "PDLIM3", "PDLIM5", "PDLIM7", "PDPR", "PDRG1", "PDS5A", "PDS5B", "PDXDC1", "PDXK", "PECR", "PEF1", "PELP1", "PES1", "PEX14", "PEX19", "PFDN2", "PFDN4", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGGT1B", "PGK1", "PGM1", "PGM2", "PGRMC1", "PGRMC2", "PHB", "PHB2", "PHF14", "PHF5A", "PHF6", "PHF8", "PHIP", "PHKA1", "PICALM", "PIGT", "PIH1D1", "PIK3C2A", "PIK3R4", "PIN1", "PIN4", "PIP4K2C", "PISD", "PITPNB", "PITRM1", "PKM", "PKMYT1", "PKN2", "PLA2G15", "PLAA", "PLBD2", "PLCG1", "PLD3", "PLD6", "PLEC", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLRG1", "PLS3", "PMPCA", "PMPCB", "PNN", "PNO1", "PNP", "PNPT1", "PODXL", "POGZ", "POLA1", "POLA2", "POLD1", "POLD2", "POLD3", "POLDIP2", "POLDIP3", "POLE", "POLE3", "POLE4", "POLR1A", "POLR1B", "POLR1E", "POLR2A", "POLR2B", "POLR2C", "POLR2G", "POLR3A", "POLR3C", "POLRMT", "PON2", "POP1", "POR", "PPA2", "PPAN", "PPFIA1", "PPHLN1", "PPIB", "PPID", "PPIF", "PPIG", "PPIH", "PPP1CA", "PPP1CB", "PPP1R10", "PPP1R7", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP4C", "PPP4R1", "PPP5C", "PPP6C", "PPT1", "PPT2", "PQBP1", "PRAF2", "PRCC", "PRCP", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PREPL", "PRIM1", "PRIM2", "PRKAG1", "PRKAR1A", "PRKAR2A", "PRKCD", "PRKCSH", "PRKDC", "PRKRA", "PRMT1", "PRMT5", "PRPF19", "PRPF3", "PRPF31", "PRPF38B", "PRPF39", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPS1", "PRPSAP1", "PRPSAP2", "PRRC1", "PRRC2C", "PSAP", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD6", "PSMD7", "PSMD8", "PSME1", "PSME2", "PSME3", "PSME4", "PSMF1", "PSMG1", "PSMG2", "PSPC1", "PTBP1", "PTBP2", "PTCD1", "PTCD3", "PTDSS1", "PTGES2", "PTGES3", "PTK7", "PTPA", "PTPN1", "PTRH2", "PUM3", "PURA", "PUS1", "PWP1", "PWP2", "PXMP2", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QKI", "QSOX2", "RAB10", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB21", "RAB23", "RAB24", "RAB2A", "RAB35", "RAB3GAP2", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RAB8A", "RABEPK", "RABGAP1", "RABGGTA", "RABL6", "RAC1", "RACGAP1", "RACK1", "RAD21", "RAD23A", "RAD23B", "RAD50", "RAE1", "RAI14", "RALA", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP9", "RANGAP1", "RANGRF", "RAP2B", "RAPGEF2", "RARS", "RARS2", "RB1", "RBBP4", "RBBP6", "RBBP7", "RBM10", "RBM12", "RBM12B", "RBM14", "RBM17", "RBM19", "RBM22", "RBM25", "RBM27", "RBM28", "RBM3", "RBM34", "RBM39", "RBM4", "RBM5", "RBM8A", "RBMX", "RCC1", "RCC2", "RCL1", "RCN1", "RCN2", "RCOR1", "RDH11", "RDH13", "RDX", "RECQL", "REEP4", "REEP5", "RELA", "REPS1", "RER1", "RETSAT", "REXO4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RHEB", "RHOT1", "RHOT2", "RIDA", "RIF1", "RINT1", "RIOK2", "RIOX1", "RMC1", "RMDN3", "RNASEH2A", "RNASET2", "RNF2", "RNF40", "ROCK1", "ROCK2", "RPA1", "RPA2", "RPAP3", "RPF2", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPN1", "RPN2", "RPP30", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RRBP1", "RRM1", "RRM2", "RRP1", "RRP12", "RRP15", "RRP1B", "RRP8", "RRS1", "RSF1", "RSL1D1", "RSL24D1", "RSU1", "RTCB", "RTFDC1", "RTN3", "RTN4", "RTRAF", "RUFY1", "RUVBL1", "RUVBL2", "RWDD1", "S100A10", "S100A11", "S100A13", "SACM1L", "SAE1", "SAFB", "SAFB2", "SAMHD1", "SAMM50", "SAP130", "SAP18", "SAP30BP", "SAR1A", "SARNP", "SARS2", "SART1", "SART3", "SASS6", "SBDS", "SC5D", "SCAMP2", "SCAMP3", "SCARB1", "SCARB2", "SCCPDH", "SCD", "SCFD1", "SCML2", "SCO1", "SCO2", "SCP2", "SCRIB", "SCRN1", "SDCBP", "SDE2", "SDF4", "SDHA", "SDHB", "SEC11A", "SEC16A", "SEC22B", "SEC23A", "SEC23IP", "SEC24A", "SEC24B", "SEC24C", "SEC24D", "SEC31A", "SEC61A1", "SEC61B", "SEC61G", "SEC62", "SEC63", "SEH1L", "SEL1L", "SENP3", "SEPHS1", "SEPT2", "SEPT7", "SEPT9", "SERBP1", "SERPINB6", "SERPINH1", "SET", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFXN1", "SFXN2", "SFXN4", "SGPL1", "SGTA", "SH3BGRL3", "SH3GL1", "SH3GLB1", "SH3PXD2B", "SHCBP1", "SHMT2", "SHOC2", "SIGMAR1", "SIL1", "SIN3A", "SKIV2L2", "SKP1", "SKP2", "SLC12A2", "SLC16A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A17", "SLC25A19", "SLC25A20", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A4", "SLC25A42", "SLC25A44", "SLC25A5", "SLC25A6", "SLC27A2", "SLC27A4", "SLC29A1", "SLC30A5", "SLC35A4", "SLC35B2", "SLC38A2", "SLC3A2", "SLC4A7", "SLC9A3R1", "SLFN11", "SLIRP", "SLK", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC6", "SMCHD1", "SMN1*", "SMNDC1", "SMPD4", "SMU1", "SND1", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPC", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNW1", "SNX1", "SNX2", "SNX27", "SNX3", "SNX5", "SNX6", "SNX9", "SOD2", "SON", "SORT1", "SPAG9", "SPART", "SPATA5", "SPATA5L1", "SPC25", "SPCS2", "SPEN", "SPNS1", "SPPL2A", "SPTAN1", "SPTBN1", "SPTBN2", "SPTLC1", "SPTLC2", "SQLE", "SQSTM1", "SRCAP", "SREK1", "SRI", "SRP14", "SRP54", "SRP68", "SRP72", "SRP9", "SRPK1", "SRPRA", "SRPRB", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF2", "SRSF3", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSNA1", "SSR1", "SSR4", "SSRP1", "STAG2", "STAM", "STAMBP", "STARD3", "STARD3NL", "STARD7", "STAT1", "STAT3", "STAU1", "STAU2", "STIP1", "STMN1", "STOM", "STOML2", "STRAP", "STRBP", "STT3A", "STT3B", "STUB1", "STX18", "STX4", "STX5", "STX7", "STX8", "STXBP3", "STXBP4", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGP2", "SUGT1", "SUN1", "SUPT16H", "SUPT5H", "SUPT6H", "SUPV3L1", "SURF4", "SURF6", "SUZ12", "SYAP1", "SYMPK", "SYNCRIP", "SYNE2", "SYNGR2", "SYS1", "TACC3", "TACO1", "TAF15", "TAF6L", "TAMM41", "TARDBP", "TARS2", "TBCA", "TBCB", "TBCD", "TBCE", "TBL2", "TBL3", "TBRG4", "TCEA1", "TCERG1", "TCOF1", "TCP1", "TDP2", "TDRKH", "TECR", "TELO2", "TERF2IP", "TEX10", "TEX264", "TFAM", "TFCP2", "TFG", "TFRC", "THADA", "THOC1", "THOC2", "THOC3", "THOC6", "THOP1", "THRAP3", "THUMPD3", "TIAL1", "TIGAR", "TIMM13", "TIMM17A", "TIMM17B", "TIMM23", "TIMM44", "TIMM50", "TIMM8A", "TIMM8B", "TIMMDC1", "TJP1", "TKT", "TLN1", "TM9SF4", "TMCO1", "TMED10", "TMED2", "TMED5", "TMED7", "TMED9", "TMEM109", "TMEM11", "TMEM126A", "TMEM14C", "TMEM192", "TMEM199", "TMEM214", "TMEM230", "TMEM259", "TMEM33", "TMEM43", "TMEM65", "TMEM97", "TMOD3", "TMPO", "TMPO", "TMSB4X", "TMTC3", "TMX1", "TMX2", "TMX4", "TNPO1", "TNPO3", "TOE1", "TOLLIP", "TOM1", "TOMM20", "TOMM22", "TOMM34", "TOMM40", "TOMM5", "TOMM70", "TOP1", "TOP2A", "TOP2B", "TOR1AIP1", "TOR1AIP2", "TOX4", "TP53", "TP53BP2", "TPD52", "TPM1", "TPM3", "TPM4", "TPP1", "TPP2", "TPR", "TPT1", "TPX2", "TRA2A", "TRA2B", "TRAF2", "TRAM1", "TRAP1", "TRAPPC11", "TRAPPC3", "TRAPPC4", "TRAPPC5", "TRIM21", "TRIM25", "TRIM28", "TRIO", "TRIP12", "TRIP13", "TRMT10C", "TRMT6", "TROVE2", "TRUB1", "TSFM", "TSG101", "TSN", "TSNAX", "TSPAN3", "TSPAN6", "TSPO", "TSR1", "TTC1", "TTC19", "TTC26", "TTC37", "TTK", "TTLL12", "TTYH3", "TUBB", "TUBB2A", "TUBB2B", "TUBB4A", "TUBB4B", "TUBB6", "TUBGCP2", "TUBGCP3", "TUFM", "TWF1", "TWF2", "TXLNG", "TXNDC12", "TXNDC5", "TXNDC9", "TXNL1", "TXNRD1", "TYMS", "U2AF2", "UBA1", "UBA2", "UBAP2L", "UBE2K", "UBE2L3", "UBE2N", "UBE2O", "UBE2Q1", "UBE2S", "UBE3C", "UBE4A", "UBR2", "UBR4", "UBR5", "UBTF", "UBXN7", "UCHL5", "UFD1", "UFL1", "UGCG", "UGGT1", "UHRF1", "UNC119B", "UNC45A", "UPF1", "UQCC2", "UQCR10", "UQCRC1", "UQCRC2", "UQCRQ", "URB1", "USMG5", "USO1", "USP10", "USP11", "USP14", "USP28", "USP39", "USP47", "USP48", "USP5", "USP7", "USP8", "USP9X", "UTP14A", "UTP15", "UTP18", "UTP20", "UTP4", "UTP6", "UTRN", "VAMP7", "VANGL1", "VAPA", "VAPB", "VARS1", "VAT1", "VBP1", "VCL", "VCP", "VDAC1", "VDAC2", "VDAC3", "VIM", "VKORC1L1", "VMP1", "VPS16", "VPS18", "VPS26A", "VPS29", "VPS33B", "VPS35", "VPS4A", "VPS4B", "VPS51", "VPS53", "VRK1", "WAPL", "WBP11", "WDHD1", "WDR1", "WDR12", "WDR18", "WDR3", "WDR33", "WDR36", "WDR4", "WDR41", "WDR43", "WDR5", "WDR61", "WDR75", "WDR77", "WDR91", "WFS1", "WIPI2", "WIZ", "WLS", "WTAP", "XAB2", "XPNPEP3", "XPO1", "XPO4", "XPO5", "XPO7", "XPOT", "XRCC5", "XRCC6", "XRN2", "YARS", "YARS2", "YBX1", "YKT6", "YLPM1", "YME1L1", "YRDC", "YTHDC1", "YTHDC2", "YTHDF2", "YTHDF3", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2", "ZC3H14", "ZC3H18", "ZCCHC11", "ZCCHC8", "ZFR", "ZFYVE16", "ZMPSTE24", "ZNF326", "ZNF638", "ZPR1", "ZW10", "ZYX"], "leading_proteins": ["ABCB1", "ABCD3", "ABHD12", "ABI1", "ACOX1", "ACP2", "ADPGK", "AGPS", "AIFM1", "AIP", "ALDH3A2", "ALG1", "ALG12", "ANKLE2", "ANLN", "ANXA11", "ANXA7", "AP1B1", "APLP2", "APOL2", "APOO", "APOOL", "APP", "ARFIP2", "ARL6IP1", "ARMC10", "ARV1", "ASAH1", "ASNA1", "ATAD3A", "ATP13A1", "ATP1A1", "ATP1B1", "ATP2A2", "ATP2C1", "ATP5F1", "ATP5L", "ATP6AP1", "ATP6AP2", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP7B", "B4GAT1", "BAG6", "BAIAP2", "BCAP31", "BCS1L", "BSG", "C12orf73", "C17orf75", "C19orf70", "C1QBP", "CACYBP", "CALU", "CANX", "CBX1", "CCDC47", "CERS2", "CETN2", "CHCHD3", "CHID1", "CHST14", "CHUK", "CISD2", "CKAP4", "CLCC1", "CLCN3", "CLN5", "CLPTM1", "CNNM4", "COL4A3BP", "COLEC12", "COMT", "COQ3", "COQ9", "COX2", "COX5A", "COX7A2", "CPOX", "CPT2", "CRK", "CRTAP", "CSGALNACT2", "CTBS", "CTNNB1", "CTSA", "CTSB", "CTSC", "CXADR", "CYB5B", "CYB5R1", "CYC1", "CYFIP1", "CYP51A1", "DCTN2", "DCTN3", "DCTN4", "DDX20", "DERL1", "DHCR24", "DHCR7", "DHRS1", "DIABLO", "DIAPH2", "DKC1", "DNASE2", "DNM1L", "DR1", "DSG2", "ECE1", "EHD1", "EHD4", "EMC7", "EMD", "EPDR1", "EPHA7", "EPHX1", "ERAP1", "ERCC2", "ERG28", "ERGIC3", 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setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Hydrolase activity hydrolyzing o glycosyl compounds 14 21 3.510280317915768 0.0004476345205457 8.830097087378642 20.84223300970874 0.5983257656540719 0.2104301479001341 3.2223833352824554 2.4557961681485057 1.9540573665272416 0.2728112677124137 1.248633769289861e-09 9.458209656697137e-08 5.931664681192189e-10 2.038687525496117e-13 3.8813142325190936e-10 +Hydrolase activity acting on glycosyl bonds 15 27 3.349558505976989 0.0008094045985289 10.133495145631068 28.40776699029126 0.6089784953463463 0.2409908190925149 3.36301188653944 3.2424277527979313 1.935823411407979 0.3010513017078077 6.828764542936875e-09 4.8602507028681495e-08 1.5889815947844423e-09 1.3340826272648299e-11 7.327899520915932e-09 +Serine hydrolase activity 9 17 3.307342103402869 0.0009418579196724 6.934466019417476 18.83009708737864 1.2767207242593377 0.1489147276149277 2.386872767465543 1.965791668457755 1.709796217367629 0.2208345231085202 2.3213136055462613e-08 0.0221752921752284 1.4997404178049758e-08 1.6899825162499072e-07 8.060398640515672e-05 +Steroid binding 10 20 3.084264621413423 0.0020405600700246 8.424757281553399 21.398058252427184 1.4469817519716153 0.1523451695819165 3.035656818503787 2.066091501771892 1.85140774519605 0.2395996334984524 6.074037232870264e-06 8.508689216563006e-05 0.0012207780133745 2.078573381251053e-07 3.6565696120738913e-07 +Alcohol binding 6 14 2.9978796282686377 0.0027186502846965 5.70873786407767 16.094660194174757 1.0972550148478282 0.1642412137618775 2.3364194162363723 2.1334758164294443 1.72577974721897 0.2306417307890987 7.933290799866498e-05 9.216009865795702e-05 0.0013172485850202 0.0001846255682835 0.0025531684631581 +Cholesterol binding 6 13 2.997464784636692 0.0027223530911559 5.25 13.29126213592233 1.1679703080780182 0.1357521674166823 1.9454015982929531 1.7674569958716484 1.7544522374432017 0.2116991383290636 3.7642690139360818e-06 1.176895700182785e-05 0.0001815434943904 5.686128654661118e-06 6.522583606885229e-05 +Sterol binding 6 15 2.995749429906272 0.0027377129528918 5.495145631067961 16.27912621359223 1.1610523788441311 0.1592175050218891 2.159304933149918 1.9111962434971217 1.7231989277496158 0.231586711794193 1.1493051269108054e-05 2.476611897309206e-05 0.0003733671894444 2.059441569286533e-05 3.983921964233757e-05 +Molecular transducer activity 14 28 2.909041563891935 0.0036253865752717 10.91747572815534 33.40533980582524 1.343848990749489 0.2329582295822712 4.7124072380860955 5.830391636254363 1.6098335072319665 0.2956883791113679 0.0342570211322353 0.3530243184113045 0.0378049213506607 0.0100633328420475 0.1223213627263454 +Peptidase activity 29 103 2.7124368513856507 0.0066790506046552 29.021844660194176 113.626213592233 1.2572335980018865 0.3731282983707893 8.334453494010912 9.805689463637474 1.5136028692995414 0.3922229485757941 1.9127085393158675e-10 0.0004500650500819 2.597730752901394e-10 8.827904794292554e-09 2.0329835388474667e-09 +Lipid transporter activity 8 16 2.6787892075638395 0.007388889280167 6.546116504854369 19.805825242718445 0.7389006587243017 0.301332987440896 3.074370954053146 3.741159812966952 1.4134673193588587 0.2984913911167897 0.0254928569459227 0.310874529382391 0.1690424872723929 0.0005267369669417 0.0038503971554757 +Ion transmembrane transporter activity 56 92 2.6745645873492925 0.0074826361495099 37.34466019417476 101.497572815534 2.0154097423383375 0.2561362875319209 17.172953606300336 11.579295798802024 2.277787478419462 0.3756175790939143 0.0054463360969378 0.0610075708845468 0.0295213058069394 0.0005353993731194 3.6515972216129527e-09 +Active transmembrane transporter activity 35 61 2.6203597780609904 0.0087837044589542 26.354368932038835 73.12621359223301 1.313035419122872 0.3239574057550545 11.878456281473593 8.663537710607383 1.88741562841277 0.3851687956916088 0.7956813521936835 0.6257595800989444 0.8606155698177973 0.2188161727555687 4.73115285035176e-06 +Glycosaminoglycan binding 7 15 2.5917633394539425 0.009548543194477 4.978155339805825 17.45631067961165 0.1337124269810174 0.5629551361084434 2.38360266105164 2.069316753377374 0.9690169198659552 0.3148101721496325 0.0145593380526055 0.0388410242837302 0.0244837275894334 0.0203556588144228 0.012770185546351 +Inorganic anion transmembrane transporter activity 13 17 2.574750979082446 0.0100312279322809 7.427184466019417 19.274271844660195 1.0921593405593897 0.2441056926448881 3.717191605498929 3.7816647851785734 1.4014196343960104 0.2816216967014333 0.0067255619426256 0.0001075756277076 0.0015259573241502 0.0015231541907095 0.0001637882770494 +Serine type exopeptidase activity 5 7 2.558749505897844 0.0105049405905472 3.783980582524272 6.997572815533981 1.020609253431403 0.1137432544246352 1.3363606860118669 0.0492066381861973 1.87035730934538 0.1990592265121372 6.849903591808147e-10 0.0007972103198291 5.543981563508339e-11 1.5040937032126972e-08 9.308926617220138e-07 +Exopeptidase activity 13 30 2.549802725635124 0.0107783889618129 9.74514563106796 31.84223300970874 1.193034763402526 0.2308543476384821 3.0338864063053523 1.9513159274241312 1.6646797512653713 0.2911825093455628 9.311134011528123e-10 0.0345877004093447 2.53535679304283e-10 1.936666177042337e-07 1.9434983841377172e-08 +Serine type carboxypeptidase activity 4 5 2.5061724706498256 0.0122046071585069 3.0558252427184467 4.997572815533981 1.0019911760482532 0.1105835516254352 1.1231414198895626 0.0492066381861973 1.8086551291944464 0.1930654928989846 6.02475339219678e-10 0.0002241871259369 7.402823185757473e-11 8.018093555049281e-09 2.618746245991888e-07 +Inorganic molecular entity transmembrane transporter activity 36 68 2.4920576513717294 0.0127005420663441 28.058252427184467 75.9635922330097 1.5031303400189615 0.2894264293069549 11.721339963426631 9.38477049228959 2.153051736566399 0.3821536813265525 0.0251990314329301 0.0288713637898469 0.0294462818629692 0.00622666829251 6.183625598268924e-06 +Exogenous protein binding 5 13 2.472163139307841 0.0134298214809129 4.509708737864078 15.157766990291265 0.7214109752050332 0.2527966464979699 2.499010078306418 1.9009100692398744 1.5211756979359785 0.2791170769282048 0.0004609575392824 0.1952735388158895 0.0693457394610891 0.0007016746800212 0.0012669874007928 +Transporter activity 68 154 2.470801064401541 0.0134810789648203 62.22330097087379 172.27912621359224 2.173366592838491 0.2707201784543502 25.984753572620328 19.29276868436311 2.593156143256053 0.3916539604106395 1.495519614598938e-06 0.0113970849074904 0.000414947085948 2.663213372809501e-09 2.3945522310845032e-14 +Cargo receptor activity 5 6 2.460855432521248 0.0138606204236744 3.7063106796116503 7.95873786407767 0.9623237890522576 0.1578680760704802 1.9530058934839476 1.7914972745396005 1.6202205206532496 0.203966946010782 2.4462273325709e-06 0.0078974776787256 0.0001376480525375 4.579056907329786e-05 0.0018986041281287 +Anion transmembrane transporter activity 23 41 2.432532597298399 0.0149936418292495 18.594660194174757 45.61893203883495 1.6222323024349488 0.2373683627198559 9.346785472607134 6.017202751823004 1.8117646078257517 0.3183345645365742 0.0023596556610388 0.0030659860564603 0.0072395357132445 0.0034907253987009 1.388487882353364e-07 +Heparin binding 5 11 2.420638128993122 0.0154932918644066 3.4344660194174756 11.91504854368932 0.417671776261347 0.5410412518682232 1.977562601051691 1.5719219414069263 0.9122022863658426 0.3149614964035694 0.0257249292436593 0.1913705796369965 0.0666692325567911 0.0901467992310857 0.0185344065780108 +Protein transmembrane transporter activity 2 12 2.418800295216641 0.0155717866078128 4.37621359223301 11.264563106796116 1.6409152716253632 0.1284874270119089 2.3258190399954897 0.995332092405782 1.387057072324357 0.2266762256512647 0.0017552448339215 0.0029386578360865 0.0005309775927247 0.0074273483269255 0.0009961752813945 +Quaternary ammonium group binding 2 10 2.4081592748879803 0.016033184477284 2.8567961165048543 12.12864077669903 0.9707568143407772 0.2573327609820879 1.4849985868988949 1.260087490061347 1.304146106648176 0.2795917987269193 0.0037696679890287 0.0001506452861526 0.0011613234829685 0.0153906222854723 0.0879711233989737 +Phosphatidylcholine binding 2 6 2.399161068459538 0.0164326846531532 2.2524271844660193 7.929611650485437 1.2697801287388335 0.1567893034984199 1.081337239384838 1.04388968498945 1.4953842980517238 0.2256102823610289 0.0014609505038688 5.590323461425328e-05 0.000440337804097 0.0062267265321947 0.0395358442373242 +Nucleobase containing compound transmembrane transporter activity 10 12 2.3914243906389228 0.0167831404151961 6.529126213592233 14.04126213592233 1.4296604886183193 0.212054291115069 3.2696940585469636 1.915888183904924 1.3255809572534116 0.2748813593420038 0.0782260641005113 1.0 0.266209970857853 0.181169408752189 0.0038758075765755 +Tetrapyrrole binding 8 14 2.3893848358114265 0.0168766140296539 7.402912621359223 16.83252427184466 2.0044897428967667 0.1259264696495541 2.9589081005845346 2.0417036568087963 1.3464702305086589 0.2177422235164347 0.043424300564073 0.0276250495673642 0.0949012099695084 0.0096445533674611 0.0010356106420026 +Peptide antigen binding 4 5 2.3693689669256988 0.0178184676980992 2.25 5.218446601941747 1.3488418251083294 0.2076946662826 1.4985834735457568 1.269832767279765 0.9581301458127084 0.2397273125927817 0.0011997221286668 1.0 0.0003602808960722 1.972516813028553e-05 0.0005240184523993 +Endopeptidase activity 20 57 2.357854288341217 0.0183809062696398 19.08495145631068 62.800970873786405 1.5604938505680932 0.2935756148549138 5.629332570724372 6.156865220927466 1.27979578418692 0.359984229645684 8.032040945546781e-07 0.008124484749935 4.0734782797727225e-06 2.556986512581974e-06 1.3945509106603109e-06 +Antigen binding 4 6 2.35781099801961 0.0183830497918136 2.504854368932039 6.936893203883495 1.1926555941065955 0.2669458193807861 1.6287691845260013 1.3674077446215156 0.9067202373946956 0.2605304200525402 0.0042894452437145 1.0 0.0013262573806951 0.0001885722773553 0.0042587077964903 +Peptide binding 15 57 2.3570898022433675 0.0184187920319454 17.133495145631066 70.30339805825243 1.21997288878307 0.3503559587509399 5.621054768990946 6.443005397350486 1.219878183292811 0.3773673755377006 0.0002817964646555 0.1570363283812061 1.113633731671856e-05 0.0002322654146421 8.484862469567786e-05 +Oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen 9 24 2.3549155843496585 0.0185269139528918 9.395631067961164 29.8373786407767 1.5709767518568172 0.2393367467664754 3.119976403291062 3.762391942431812 1.2135099906711824 0.3124947384976632 0.3921999581802649 0.0734458650364987 0.2248900268904883 0.0252029938936908 0.0051672295609291 +Amide binding 21 87 2.352696075323112 0.0186378606553785 22.521844660194176 102.53398058252426 0.8716704131409604 0.4134472412494542 7.596116055031058 7.786365397071367 1.2519470693533183 0.3815633057547212 8.900235007003937e-06 0.0004286258681045 7.60584474385145e-08 2.4883637467225303e-06 2.1841477061616486e-06 +Anion channel activity 4 10 2.3448308303794283 0.0190357143631243 4.20873786407767 11.21116504854369 1.03959259790327 0.2192420598609839 2.3076742714116403 2.0905640066649145 1.3937691950814175 0.2662450395835827 0.0006654756546629 8.855241383339473e-06 0.0001376480525375 0.0004989114687539 0.0018986041281287 +Secondary active transmembrane transporter activity 16 19 2.3380990935695745 0.0193821082351526 9.080097087378642 21.490291262135923 1.2627683473613005 0.2947710034053126 5.466215032972134 3.0675886156990426 1.4241587428281404 0.3340388164945335 0.725358103545908 0.3467229085425889 0.5741114914523541 0.6332347998981533 0.0002961568832283 +Sphingolipid binding 4 8 2.336419333610863 0.0194693972861403 3.2305825242718447 6.810679611650485 1.3881601090528384 0.1287371848492678 1.3662849673921555 1.293404675510669 1.5116584105270494 0.2146285912590262 0.0001113329160673 1.3710267859167043e-06 2.214575962840231e-05 5.302129833761715e-05 0.0001413957013589 +Gated channel activity 4 12 2.318210616034096 0.0204378773592257 4.317961165048544 13.019417475728156 0.8697524591818097 0.2583579989367679 2.2914716766946497 2.0107989163575497 1.3733766112751231 0.2762671399351702 0.0110835876877107 0.0001883783937456 0.0025924072114898 0.0148252690690975 0.0693300967684576 +Metalloendopeptidase activity 5 14 2.312873604506367 0.0207295894507748 5.449029126213592 14.364077669902912 1.4597326207035937 0.2246869419023046 2.4848715129851016 0.6671711573432166 0.9390012824303952 0.2775881383017788 0.0118914584472129 0.1471951297158956 0.0398064357050217 0.0449350347407693 0.0045472220952188 +Fad binding 6 10 2.3021303748058872 0.0213278209298832 3.78883495145631 9.932038834951456 1.575439945642976 0.1698004033102896 1.8828741719818296 1.250336932628077 0.9196006746446306 0.2289411404885479 0.0541972194107464 1.0 0.2223047329091382 0.0242110622206542 0.0012597640157874 +Mannose binding 3 7 2.288120071995285 0.0221305296491907 2.487864077669903 6.235436893203883 0.6101269701833572 0.2582145467051042 1.3337836904766196 0.6757998162537485 1.36750331402198 0.2531492078603038 0.0001591095494268 5.743829058688599e-06 4.656667989155393e-05 2.1797401302891516e-05 0.0003260526470588 +Carboxypeptidase activity 4 12 2.283397788525444 0.0224069474180903 3.941747572815534 11.944174757281552 0.6619369631013473 0.2217581052142344 1.5253536449314826 0.7722681563953175 1.6063564059694095 0.2594343390807456 2.048990347914044e-05 0.0058373227860703 2.722163485266692e-06 0.0002335266734922 0.0007997701188881 +Protein transporter activity 3 15 2.263595775081927 0.0235989879473108 6.053398058252427 14.696601941747574 1.6882240898296943 0.1359359142649309 2.957968193176 1.443999336657768 1.4805047019217734 0.2345897542974644 0.0054540651163694 0.0063255491406275 0.0016986126979642 0.0028478177309091 0.0010098105424835 +Hexosaminidase activity 3 5 2.2575331693047453 0.0239747792932318 2.5194174757281553 4.973300970873787 0.3568105957806153 0.2227497456156347 1.091499214132507 0.3065083294438748 1.6445593916296413 0.2548912926080147 0.0002361262018994 0.0424464003246627 6.936272072908627e-05 3.848915456526504e-05 2.80346154767832e-05 +Glycolipid binding 3 6 2.24347335395198 0.0248663062672866 3.95873786407767 9.17233009708738 1.1300394975336625 0.1723818604496332 1.779261971800237 1.789101691327159 1.517965150696512 0.2390589148665743 8.757696349628895e-05 6.765318543664244e-05 1.7352123755419733e-05 0.00062382482254 0.0009961752813945 +Macromolecule transmembrane transporter activity 2 13 2.233446111413451 0.0255195402495258 4.820388349514563 12.281553398058252 1.6605285757306012 0.1306403746261988 2.4754663863133306 1.0160601209961664 1.3599823000893485 0.2280235038874096 0.0028503379556391 0.0040679264544396 0.0008717411361388 0.01180448121602 0.0002717294391002 +Lipid binding 24 114 2.189495955292927 0.0285608122092713 30.883495145631063 138.65533980582524 0.9844637598707308 0.4289871747751645 8.92748670410201 14.760635317682617 1.446857667744565 0.4068298387995807 7.213715628823211e-06 0.0002452634866971 9.230383645644614e-05 8.774087645265334e-05 0.0019714001944758 +Growth factor binding 6 13 2.1846510993190136 0.0289144382022865 4.310679611650485 12.949029126213592 -0.0488380105863232 0.5194853451197696 2.1509949209095054 2.534197950354086 1.057563900891323 0.317878019437427 0.6366228252803857 0.2835996474450377 0.0285769937968429 0.0256413459661662 0.048774148584623 +Organic acid transmembrane transporter activity 11 19 2.177840694332934 0.0294178990480844 8.592233009708737 21.276699029126213 1.5973629153049684 0.1905568538747131 4.4420473133518055 2.549726956007885 1.3213968531498468 0.2647933566957936 0.0169414543082816 1.0 0.1388614812827933 0.0824194625829831 8.917551346587106e-05 +Ceramide binding 4 6 2.16824844316692 0.0301397888147962 2.8228155339805827 5.048543689320389 1.42330045764979 0.1242195400491618 1.17628831869178 0.9309003969609838 1.481980135982154 0.2133994029014766 2.7528489700449297e-05 3.260682492863553e-07 5.369271916582234e-06 8.796898694645245e-06 1.6091572544199994e-05 +Udp glycosyltransferase activity 5 12 2.1660660530802724 0.0303061398186652 5.111650485436893 16.645631067961165 0.3599735227181602 0.3819150449260511 2.50187506268716 3.5246228662547776 1.2344018614792536 0.2994506580113357 0.0234060243887033 0.3041527321586795 0.0353550186833354 0.1083386684032722 0.0703963670995082 +Nucleotide transmembrane transporter activity 8 10 2.149540264135648 0.0315915979041709 5.606796116504855 12.029126213592232 1.4217258291760082 0.2036087501116975 3.0234925518113496 1.8899648667798992 1.291115513359647 0.2666064512499804 0.0366975247182733 1.0 0.1837383274168749 0.090818300458346 0.0027898710574492 +Organophosphate ester transmembrane transporter activity 8 10 2.149540264135648 0.0315915979041709 5.665048543689321 12.143203883495143 1.4298365636921646 0.2056324024803549 3.029697948284232 1.927415248708952 1.2819429632405106 0.2680490563295835 0.039990310390257 1.0 0.191600110602388 0.0983610682747182 0.0034687949642114 +Collagen binding 4 9 2.1341550224483834 0.0328300930910592 2.716019417475728 8.723300970873787 0.69823887636622 0.4150184287426759 1.4191600413356955 1.3333441338677146 0.9396547940704922 0.2968068810392446 0.3648863242474894 0.1389130578490434 0.2590666885683055 0.0383377547470353 0.0156507911863037 +Active ion transmembrane transporter activity 25 36 2.103698008806818 0.0354047982725642 16.271844660194176 41.71116504854369 1.2957221273899948 0.3267733012969381 7.788084220174416 5.097264791179653 1.6571109350293016 0.3632481416270505 0.5136039945356081 0.4354616437047781 0.6821824234140106 0.1582163702578203 5.040206982776925e-05 +Antiporter activity 8 9 2.09417079614637 0.0362447682812874 4.621359223300971 10.405339805825244 1.056576117278179 0.2813324268221227 2.679901841610502 1.304685592846984 1.2558310293487471 0.3063102364368053 0.4352241640586226 0.1715759324473242 0.3143397790261298 0.616426174876278 0.0104893431674361 +Voltage gated anion channel activity 3 5 2.09195189627184 0.0364428190175192 2.854368932038835 6.25 1.127126362633441 0.1649553590552043 1.5417035527207152 0.9966570336472054 1.4583344406160936 0.2334940994157564 0.0003337381585488 1.2225095413484733e-05 9.839858993160587e-05 6.292953854873037e-05 5.383729574080712e-05 +Cation transmembrane transporter activity 38 65 2.09194130255918 0.0364437667803749 25.62135922330097 70.51699029126213 1.766742880952279 0.2698419237572138 12.29126021871486 8.422243011776631 2.00238274385689 0.3706372466673562 0.1197434436132319 0.6755398045514229 0.3836456925968915 0.0105162900829293 6.634254304289342e-06 +Symporter activity 7 8 2.0756315337698674 0.0379280426334696 3.638349514563106 9.1747572815534 0.9770544165414302 0.3122690599192905 2.3735568316725377 2.065327188945721 1.1044541290009051 0.3081067804681572 1.0 1.0 1.0 0.6608597677231411 0.0048404074215544 +Sodium ion transmembrane transporter activity 6 7 2.069244839064314 0.0385231169992583 3.033980582524272 6.733009708737864 0.6330876716410718 0.3951789521880264 1.773267150762252 1.4834287460359985 1.0827590126064015 0.3202441368223486 1.0 1.0 1.0 0.2526409373615763 0.0027819419936207 +Sterol transporter activity 3 8 2.056535380531637 0.0397309396037495 2.621359223300971 8.364077669902912 0.5454888897585024 0.2973249899153176 1.425267849835305 1.6080715320593837 1.318674977748992 0.2709274408896192 0.0042894452437145 0.1049896535105009 0.1993869387044997 0.0020705519968491 0.0042587077964903 +Snap receptor activity 4 8 2.053155604295512 0.0400574885881228 5.803398058252427 13.6626213592233 0.8920027438628428 0.3386294703372389 3.103034547770364 2.9171839264116786 1.2201519782198902 0.3219991979242683 1.0 1.0 1.0 0.5661975770404395 0.0227729863487681 +Palmitoyl protein hydrolase activity 2 5 1.9978198128050788 0.0457361985452053 1.91747572815534 5.429611650485437 0.9780254626091984 0.222941388490727 1.137611804765983 0.8139540579221628 1.3123017012345466 0.2566673774233151 0.0125560894119173 0.0014481500629001 0.0056684159955205 0.00262770885776 0.0019736987849612 +Phospholipid binding 9 72 1.9919732636625893 0.0463739914741905 18.890776699029125 88.4635922330097 0.777309720287493 0.452120200534915 6.970479526806733 10.51702894240924 1.1988133109990275 0.3785217149858343 0.0125208401337829 0.0030763239140551 0.0006260713922398 0.0636016933799903 0.1466704026990853 +Atpase binding 7 27 1.9754860118592832 0.0482130204790807 7.101941747572815 27.883495145631063 0.4324538219085727 0.5124445450748666 3.2760229435557595 2.201283698181438 0.9496598819558206 0.3233068270066163 0.0145593380526055 1.0 0.1290920553826253 0.0001621519489155 0.012770185546351 diff --git a/msigdb_gomf/metrics.json b/msigdb_gomf/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..124f446a3e265adb508d98033e1e35a38706b191 --- /dev/null +++ b/msigdb_gomf/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2644, + "annotations_size": 1330, + "title": "Average number of proteins per term", + "value": 14.634586466165414 +} \ No newline at end of file diff --git a/msigdb_gomf/paths.json b/msigdb_gomf/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..c1a811d8c06cf5f9641fc31231ecf0d095a7fd1e --- /dev/null +++ b/msigdb_gomf/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/msigdb_gomf/fragment/C197/C197_val_log2fc"} \ No newline at end of file diff --git a/msigdb_gomf/result.tsv b/msigdb_gomf/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..c45ab80e6b458f55abaf57bccdfca685790267c7 --- /dev/null +++ b/msigdb_gomf/result.tsv @@ -0,0 +1,376 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Hydrolase activity hydrolyzing o glycosyl compounds 0.8766641865997477 3.510280317915768 0.0004476345205457 0.4487060913899002 0.4175570110548066 21 P10253,P16278,O00462,P08236,P06280,P07686,P54802,P04066,Q01459,Q9BTY2,O00754,Q9NUJ1,P17900,P06865 14 +Hydrolase activity acting on glycosyl bonds 0.8335419400820533 3.3495585059769892 0.0008094045985289 0.6593650886962346 0.4175570110548066 27 P10253,O75503,P16278,O00462,P08236,P06280,P07686,P54802,P04066,Q01459,Q9BTY2,O00754,Q9NUJ1,P17900,P06865 15 +Serine hydrolase activity 0.8555807119362449 3.307342103402869 0.0009418579196724 0.7144280657865527 0.4175570110548066 17 O75976,Q9HB40,P10619,Q5JRX3,Q16740,P42785,Q9H3G5,P53634,O14773 9 +Steroid binding 0.7967914774397401 3.084264621413423 0.0020405600700246 0.933908666293627 0.4551447784182659 20 P04062,O95772,P45880,P30536,P61916,O15173,O00264,P21796,O15118,Q14108 10 +Alcohol binding 0.8335895278003432 2.9978796282686377 0.0027186502846965 0.97323683720441 0.4551447784182659 14 O95772,P45880,P61916,P21796,O15118,Q14108 6 +Cholesterol binding 0.8459834364176654 2.997464784636692 0.0027223530911559 0.9733686723886202 0.4551447784182659 13 O95772,P45880,P61916,P21796,O15118,Q14108 6 +Sterol binding 0.8205854848885752 2.995749429906272 0.0027377129528918 0.9739086533603728 0.4551447784182659 15 O95772,P45880,P61916,P21796,O15118,Q14108 6 +Molecular transducer activity 0.7527993347170617 2.909041563891935 0.0036253865752717 0.9920176762011998 0.5036430904787771 28 Q99523,P11717,O14786,Q15375,Q8WTV0,O75787,P30536,O15173,Q99720,Q15629,O15118,Q14108,Q5KU26,Q9BUN8 14 +Peptidase activity 0.5525177254057051 2.7124368513856507 0.0066790506046552 0.9998653639737808 0.5036430904787771 103 P07858,Q9HB40,Q5JRX3,P55786,Q99538,P09960,P67812,P42892,Q8TCT8,Q9NZ08,O75976,P20618,Q96FW1,O75844,P49721,O14773,P10619,Q9UIQ6,Q16740,Q92820,P42785,Q9H3G5,P53634,P49720,P28070,P02786,O95630,P28072,Q92542 29 +Lipid transporter activity 0.7477096034149482 2.6787892075638395 0.007388889280167 0.9999479709692392 0.5036430904787771 16 Q9Y5P4,O14975,P30536,P61916,Q9H2C2,O15118,Q96GC9,P17900 8 +Ion transmembrane transporter activity 0.535435652909043 2.6745645873492925 0.0074826361495099 0.9999541128808482 0.5036430904787771 92 Q9HC21,Q8TB61,P12235,Q9UDW1,P08574,P05141,O95202,P53985,Q96ES6,P21796,Q86VD7,Q9UBX3,Q9C0H2,P20674,Q9Y619,P08195,P45880,P51798,P55011,P00403,P51790,Q99808,Q00325,P61421,P16615,Q93050,P35670,Q9BXP2,O75964,P05026,Q9H2D1,Q6P4A7,P24539,P31930,P98194,O43681,Q02978,Q15758,Q6P4Q7,O43772,Q70HW3,Q8TAD4,Q96NB2,Q9Y277,Q9Y487,P12236,Q13423,P05023,Q9HD20,Q96S66,Q8N4V1,Q9Y6M7,Q6NUK1,Q96QD8,O95563,Q6N075 56 +Active transmembrane transporter activity 0.5870369384598509 2.6203597780609904 0.0087837044589542 0.999991982921035 0.5036430904787771 61 P12235,Q9UDW1,P08574,P05141,P53985,Q96ES6,Q9UBX3,P20674,P08195,P08183,O96000,P51798,P55011,P00403,P51790,Q00325,P61421,P16615,P35670,Q9BXP2,P05026,P31930,O43674,P98194,Q02978,Q15758,P28288,Q15388,P12236,O75306,O43676,P05023,Q9HD20,Q9Y6M7,Q96QD8 35 +Glycosaminoglycan binding 0.7428951004197266 2.5917633394539425 0.009548543194477 0.9999971282310344 0.5036430904787771 15 Q53GQ0,O14786,Q06481,O94813,P05067,Q07021,P15586 7 +Inorganic anion transmembrane transporter activity 0.7171336342202166 2.574750979082446 0.0100312279322809 0.9999984982808762 0.5036430904787771 17 P51798,P55011,P45880,Q9BXP2,O43681,P51790,Q96S66,Q9Y6M7,P21796,Q9UBX3,Q9C0H2,Q6N075,Q9Y277 13 +Serine type exopeptidase activity 0.9337169489807609 2.558749505897844 0.0105049405905472 0.9999992054375644 0.5036430904787771 7 O75976,Q9HB40,P10619,P42785,O14773 5 +Exopeptidase activity 0.6887339874419846 2.549802725635124 0.0107783889618129 0.999999449848676 0.5036430904787771 30 O75976,Q9HB40,P10619,P02786,P55786,Q9UIQ6,Q92820,P09960,P42785,O75844,Q9H3G5,P53634,O14773 13 +Serine type carboxypeptidase activity 0.9696854869268668 2.5061724706498256 0.0122046071585069 0.9999999192569768 0.5036430904787771 5 O75976,P42785,P10619,Q9HB40 4 +Inorganic molecular entity transmembrane transporter activity 0.5322889909145754 2.4920576513717294 0.0127005420663441 0.9999999585966868 0.5036430904787771 68 P12235,Q9UDW1,Q96ES6,P21796,Q9UBX3,Q9C0H2,P20674,P08195,P51798,P55011,P45880,P00403,P51790,Q00325,P61421,P16615,Q93050,P35670,Q9BXP2,O75964,P05026,P24539,P31930,P98194,O43681,Q6P4Q7,Q8TAD4,Q9Y277,Q9Y487,P05023,Q13423,Q9HD20,Q96S66,Q9Y6M7,Q96QD8,Q6N075 36 +Exogenous protein binding 0.7421328420663394 2.472163139307841 0.0134298214809129 0.999999984504045 0.5036430904787771 13 P11279,Q8WTV0,P02786,O15118,Q14108 5 +Transporter activity 0.5814903602121424 2.470801064401541 0.0134810789648203 0.9999999855386906 0.5036430904787771 154 Q99595,Q8TB61,P12235,Q8IXU6,P30536,Q9UDW1,P53985,Q96ES6,P21796,Q9UBX3,Q9H2V7,Q9C0H2,P08195,Q9Y619,P08183,O14925,O96000,O60830,P45880,O14975,P61916,P51798,P55011,P51790,Q99808,Q00325,P61421,P16615,Q93050,P35670,Q96GC9,O75964,P05026,P04062,Q9H2D1,Q6P4A7,Q8WTV0,Q9NS69,P51991,P24539,P22059,O43674,O43681,Q15758,Q9H2C2,Q6P4Q7,O43772,Q70HW3,Q96H78,Q8TAD4,Q96NB2,P17900,Q9Y277,Q15388,Q9Y487,Q9Y5P4,P12236,O75306,O43676,Q13423,Q5T1Q4,O15173,Q9HD20,P05023,Q9Y6M7,O15118,Q96QD8,O95563 68 +Cargo receptor activity 0.9469294920394212 2.460855432521248 0.0138606204236744 0.9999999913315496 0.5036430904787771 6 Q8WTV0,P02786,Q14108,Q5KU26,Q08380 5 +Anion transmembrane transporter activity 0.644884565938152 2.432532597298399 0.0149936418292495 0.9999999981210508 0.5036430904787771 41 P12235,Q8TB61,P53985,P21796,Q9UBX3,Q9C0H2,P08195,Q9Y619,P51798,P55011,P45880,P51790,Q99808,Q9H2D1,O43681,Q15758,Q96NB2,Q9Y277,P12236,Q96S66,Q9Y6M7,Q96QD8,O95563 23 +Heparin binding 0.7530527144717264 2.420638128993122 0.0154932918644066 0.9999999990431498 0.5036430904787771 11 Q53GQ0,O14786,Q06481,O94813,P05067 5 +Protein transmembrane transporter activity 0.7423778024205152 2.418800295216641 0.0155717866078128 0.9999999991394244 0.5036430904787771 12 Q99595,O60830 2 +Quaternary ammonium group binding 0.7870080152352263 2.4081592748879803 0.016033184477284 0.9999999995386812 0.5036430904787771 10 Q14108,P21796 2 +Phosphatidylcholine binding 0.931300562555624 2.399161068459538 0.0164326846531532 0.9999999997311948 0.5036430904787771 6 Q14108,P21796 2 +Nucleobase containing compound transmembrane transporter activity 0.7370968166822932 2.3914243906389228 0.0167831404151961 0.9999999998326632 0.5036430904787771 12 Q9HC21,P12235,Q8TB61,Q9H2D1,P51991,P12236,P05141,Q99808,Q6NUK1,L0R6Q1 10 +Tetrapyrrole binding 0.7159627225251673 2.3893848358114265 0.0168766140296539 0.9999999998525394 0.5036430904787771 14 P30519,Q9H7Z7,O15173,O00264,O43169,Q16850,Q8WUJ1,Q6UW02 8 +Peptide antigen binding 0.9348237968927632 2.3693689669256988 0.0178184676980992 0.999999999958786 0.5036430904787771 5 P55899,P01889,P10321,Q15392 4 +Endopeptidase activity 0.5748825196956744 2.3578542883412172 0.0183809062696398 0.9999999999807608 0.5036430904787771 57 P07858,Q5JRX3,Q99538,P67812,P42892,Q8TCT8,Q9NZ08,P20618,Q10713,O75844,P49721,O14773,O43847,Q16740,P49720,P53634,P28070,Q99436,P28072,Q92542 20 +Antigen binding 0.9208902835889728 2.35781099801961 0.0183830497918136 0.9999999999808166 0.5036430904787771 6 P55899,P01889,P10321,Q15392 4 +Peptide binding 0.5747879610535344 2.3570898022433675 0.0184187920319454 0.9999999999817236 0.5036430904787771 57 Q9NQX7,P01889,Q8WTV0,Q9H7Z7,P24390,P55786,Q9UIQ6,O00264,Q15392,P04439,P10321,P42892,P55899,O14773,Q9NZ08 15 +Oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen 0.6644232970315419 2.3549155843496585 0.0185269139528918 0.9999999999842144 0.5036430904787771 24 P13674,Q9NWT6,P30519,Q14534,O75845,Q32P28,Q16850,Q6UW02,Q8NB78 9 +Amide binding 0.4971976452697414 2.3526960753231116 0.0186378606553785 0.999999999986418 0.5036430904787771 87 Q9UM22,Q9H7Z7,P55786,P07602,P21796,P42892,Q9NZ08,Q9NQX7,P01889,P45880,P04439,O14773,Q8WTV0,P24390,Q9UIQ6,Q15392,P10321,P55899,Q9Y5P4,O00264,Q9Y680 21 +Anion channel activity 0.7739123789960185 2.3448308303794283 0.0190357143631243 0.9999999999920796 0.5036430904787771 10 P45880,P21796,P51790,Q9C0H2 4 +Secondary active transmembrane transporter activity 0.6642551509395037 2.3380990935695745 0.0193821082351526 0.9999999999950484 0.5036430904787771 19 P12235,P12236,P51798,P55011,P05141,P51790,P53985,Q02978,Q96ES6,Q15758,Q00325,Q9UBX3,Q9Y6M7,P08195,Q96QD8,Q9BXP2 16 +Scavenger receptor activity 0.9662878787878796 2.337279417695242 0.0194246600383019 0.999999999995326 0.5036430904787771 4 Q14108,Q8WTV0,Q08380 3 +Sphingolipid binding 0.8434867056491709 2.336419333610863 0.0194693972861403 0.9999999999956012 0.5036430904787771 8 P45880,Q9UM22,P21796,P07602 4 +Gated channel activity 0.7230607112987621 2.318210616034096 0.0204378773592257 0.9999999999988182 0.5036430904787771 12 P45880,P21796,P51790,Q9C0H2 4 +Metalloendopeptidase activity 0.7017977069411909 2.312873604506367 0.0207295894507748 0.9999999999992047 0.5036430904787771 14 Q10713,Q5JRX3,O75844,P42892,O43847 5 +Fad binding 0.7651394888238372 2.3021303748058872 0.0213278209298832 0.9999999999996472 0.5036430904787771 10 O95831,Q14534,Q15067,Q15392,Q8NB78,Q9UHQ9 6 +Mannose binding 0.8682571525136809 2.2881200719952854 0.0221305296491907 0.9999999999998817 0.5036430904787771 7 P11717,O75503,O00462 3 +Carboxypeptidase activity 0.7164306983436886 2.283397788525444 0.0224069474180903 0.9999999999999186 0.5036430904787771 12 O75976,P42785,P10619,Q9HB40 4 +Protein transporter activity 0.6826301748255944 2.263595775081927 0.0235989879473108 0.999999999999984 0.5036430904787771 15 Q99595,O60830,Q9NS69 3 +Hexosaminidase activity 0.9067285410657444 2.2575331693047453 0.0239747792932318 0.9999999999999905 0.5036430904787771 5 P54802,P17900,P06865 3 +Glycolipid binding 0.8923699618452845 2.2434733539519796 0.0248663062672866 0.9999999999999972 0.5036430904787771 6 Q9UM22,P50897,P07602 3 +Macromolecule transmembrane transporter activity 0.6971501693781602 2.233446111413451 0.0255195402495258 0.9999999999999988 0.5036430904787771 13 Q99595,O60830 2 +Lipid binding 0.5129193198567371 2.189495955292927 0.0285608122092713 1.0 0.5036430904787771 114 Q9UM22,P30536,P50897,Q9BQE5,P07602,P21796,Q14108,P11717,P45880,P61916,O14773,P04062,Q06481,Q8WTV0,Q8NCC3,O00560,P28070,O95772,Q9Y5P4,O15173,Q15067,O15118,Q9NQZ5,A6NIH7 24 +Oxidoreductase activity acting on a sulfur group of donors oxygen as acceptor 0.9279701361749438 2.186133561622885 0.0288058352190336 1.0 0.5036430904787771 4 Q9UHG3 1 +Growth factor binding 0.6881160568943137 2.1846510993190136 0.0289144382022865 1.0 0.5036430904787771 13 Q99523,P11717,O14786,Q15375,O00560,Q92896 6 +Organic acid transmembrane transporter activity 0.6371469014190289 2.177840694332934 0.0294178990480844 1.0 0.5036430904787771 19 Q96H78,Q9H2D1,O14975,O95563,Q15758,P53985,Q9UBX3,Q96QD8,P08195,Q9Y619,P08183 11 +Ceramide binding 0.8738131483576251 2.1682484431669193 0.0301397888147962 1.0 0.5036430904787771 6 P45880,Q9UM22,P21796,P07602 4 +Udp glycosyltransferase activity 0.6942903890348708 2.1660660530802724 0.0303061398186652 1.0 0.5036430904787771 12 Q10472,P07686,Q16739,O43505,P06865 5 +Nucleotide transmembrane transporter activity 0.7341566341215369 2.149540264135648 0.0315915979041709 1.0 0.5036430904787771 10 Q9HC21,P12235,Q8TB61,Q9H2D1,P12236,P05141,Q99808,Q6NUK1 8 +Organophosphate ester transmembrane transporter activity 0.7341566341215369 2.149540264135648 0.0315915979041709 1.0 0.5036430904787771 10 Q9HC21,P12235,Q8TB61,Q9H2D1,P12236,P05141,Q99808,Q6NUK1 8 +Collagen binding 0.7632867812090278 2.1341550224483834 0.0328300930910592 1.0 0.5036430904787771 9 Q92791,O75718,P07858,Q32P28 4 +Protein lipid complex binding 0.9117042379263094 2.12127376360845 0.0338987709250853 1.0 0.5036430904787771 4 Q9BQE5,Q8WTV0 2 +Active ion transmembrane transporter activity 0.6083723579121886 2.103698008806818 0.0354047982725642 1.0 0.5036430904787771 36 P12235,Q9UDW1,P08574,P05141,Q96ES6,P20674,P08195,P51798,P55011,P00403,P51790,Q00325,P61421,P16615,P35670,Q9BXP2,P05026,P31930,P98194,Q02978,P12236,P05023,Q9HD20,Q9Y6M7,Q96QD8 25 +Antiporter activity 0.7548387096774266 2.09417079614637 0.0362447682812874 1.0 0.5036430904787771 9 P12235,P12236,P51798,Q02978,P05141,P51790,Q9UBX3,P08195 8 +Aspartic type peptidase activity 0.9044160534116964 2.092079933838278 0.0364313658416057 1.0 0.5036430904787771 4 Q8TCT8 1 +Voltage gated anion channel activity 0.8657659463538764 2.09195189627184 0.0364428190175192 1.0 0.5036430904787771 5 P45880,P21796,P51790 3 +Cation transmembrane transporter activity 0.5054831915712017 2.09194130255918 0.0364437667803749 1.0 0.5036430904787771 65 Q9HC21,P12235,Q9UDW1,P08574,P05141,O95202,Q96ES6,P20674,P08195,Q9Y619,P55011,P00403,P51790,Q99808,Q00325,P61421,P16615,Q93050,P35670,Q9BXP2,O75964,P05026,P24539,P31930,P98194,Q15758,Q6P4Q7,O43772,Q70HW3,Q96NB2,Q8TAD4,Q9Y487,P05023,Q13423,Q9HD20,Q8N4V1,Q9Y6M7,Q96QD8 38 +Symporter activity 0.7849013657056068 2.0756315337698674 0.0379280426334696 1.0 0.5036430904787771 8 P55011,Q15758,P53985,Q96ES6,Q00325,Q9Y6M7,Q96QD8 7 +Sodium ion transmembrane transporter activity 0.8168373151308267 2.069244839064314 0.0385231169992583 1.0 0.5036430904787771 7 P05026,P55011,Q6P4Q7,Q9Y6M7,Q96QD8,P08195 6 +Sterol transporter activity 0.7806809417534528 2.0565353805316375 0.0397309396037495 1.0 0.5036430904787771 8 P30536,P61916,O15118 3 +Snap receptor activity 0.7799349326545574 2.0531556042955117 0.0400574885881228 1.0 0.5036430904787771 8 Q9UNK0,O15400,Q9P2W9,P51809 4 +Beta n acetylhexosaminidase activity 0.8889159537078588 2.029724346656476 0.0423845666827471 1.0 0.5036430904787771 4 P17900,P06865 2 +Acetylglucosaminyltransferase activity 0.883790386994254 2.00902564312165 0.0445344143179224 1.0 0.5036430904787771 4 O43505,P06865 2 +Palmitoyl protein hydrolase activity 0.8427985108649042 1.9978198128050788 0.0457361985452053 1.0 0.5036430904787771 5 P50897,Q9NUJ1 2 +Phospholipid binding 0.457815995141682 1.9919732636625893 0.0463739914741905 1.0 0.5036430904787771 72 Q9UM22,Q06481,Q8WTV0,P45880,P50897,P07602,P21796,Q14108,O14773 9 +Atpase binding 0.6010181747381289 1.9754860118592832 0.0482130204790807 1.0 0.5036430904787771 27 P05026,Q9Y487,Q16740,Q8NFQ8,Q93050,Q92542,Q9BUN8 7 +G protein alpha subunit binding 0.95456266565695 1.9690148182244864 0.0489513894777324 1.0 0.5036430904787771 3 P11717,P80303 2 +Aspartic endopeptidase activity intramembrane cleaving 0.9537161614000764 1.9656771541580724 0.0493359154462247 1.0 0.5036430904787771 3 Q8TCT8 1 +Wide pore channel activity 0.8727622101304762 1.9643597444788607 0.0494883877285947 1.0 0.5036430904787771 4 P45880,P21796 2 +Porin activity 0.8727622101304762 1.9643597444788607 0.0494883877285947 1.0 0.5036430904787771 4 P45880,P21796 2 +Oxidoreductase activity acting on other nitrogenous compounds as donors 0.8727128640907409 1.96415948895709 0.0495115991600196 1.0 0.5036430904787771 4 O43169 1 +Nadh dehydrogenase activity 0.5998891891175213 1.953583054618199 0.0507505462424788 1.0 0.5036430904787771 18 O96000,O75306,O95831,O43676 4 +Carbohydrate derivative transmembrane transporter activity 0.7247348658927877 1.9501821684388176 0.0511544103502656 1.0 0.5036430904787771 9 P12235,Q8TB61,P12236,P05141,Q99808,Q6NUK1,L0R6Q1 7 +Threonine type endopeptidase activity 0.7561484137832274 1.9447159348381005 0.0518091766137511 1.0 0.5036430904787771 8 P20618,Q99436,P49720,P49721,P28072,P28070 6 +Threonine type peptidase activity 0.7225720801835561 1.9397472047363884 0.0524104197090751 1.0 0.5036430904787771 9 P20618,Q99436,P49720,P49721,P28072,P28070 6 +Organic anion transmembrane transporter activity 0.5953260820943991 1.9388306377060691 0.0525219641612759 1.0 0.5036430904787771 27 Q9HC21,Q8TB61,P12235,P05141,P53985,Q86VD7,Q9UBX3,P08195,Q14728,Q9Y619,Q99808,Q9H2D1,Q02978,Q15758,Q96NB2,P12236,Q9Y6M7,Q6NUK1,Q96QD8,O95563 20 +Mannosidase activity 0.9374844438882282 1.901525211414784 0.0572332534663004 1.0 0.5036430904787771 3 O00462 1 +Monooxygenase activity 0.7776025303718039 1.898523952004085 0.0576270956202509 1.0 0.5036430904787771 7 Q14534,Q16850,P30519,Q6UW02 4 +Signaling receptor regulator activity 0.6181896851339785 1.8975449157432007 0.0577560566257551 1.0 0.5036430904787771 15 P43490,Q15375,P05067 3 +Vitamin transmembrane transporter activity 0.8561281533889891 1.89665999187017 0.0578728272453481 1.0 0.5036430904787771 4 Q9H2D1 1 +Tap binding 0.9341158652025732 1.8881764148678863 0.0590022709750188 1.0 0.5036430904787771 3 P01889,P10321 2 +Amino acid transmembrane transporter activity 0.6815458260448242 1.8840299646183287 0.0595609224190605 1.0 0.5036430904787771 10 Q15758,Q96QD8,P08195,Q9Y619,Q96H78 5 +Oxidoreduction driven active transmembrane transporter activity 0.586309346847273 1.868850671723174 0.0616435927965464 1.0 0.5036430904787771 23 O96000,P13073,O75489,P31930,Q9UDW1,O43674,P08574,P00403,O75306,O43676,P20674 11 +Metallopeptidase activity 0.5703382105155473 1.8668589331667953 0.0619212900377941 1.0 0.5036430904787771 38 O75976,Q10713,P02786,O95630,Q5JRX3,P55786,Q9UIQ6,P09960,Q9BYT8,O75844,P42892,O43847,Q9NY33,Q9NZ08 14 +Retromer complex binding 0.810000028498036 1.861837507495997 0.0626259978567134 1.0 0.5036430904787771 5 Q99523,P11717 2 +Peptidase activator activity 0.6449921122143135 1.8518114359126152 0.0640529049055511 1.0 0.5036430904787771 11 P05067 1 +Proteoglycan binding 0.9242711094282516 1.8490976010403823 0.0644437207349191 1.0 0.5036430904787771 3 O94813,P07858 2 +Serine type endopeptidase inhibitor activity 0.7948415698120288 1.840872700650182 0.0656402158024609 1.0 0.5036430904787771 6 P05067 1 +Metalloexopeptidase activity 0.5812301804335949 1.8390630322700685 0.0659059155732582 1.0 0.5036430904787771 18 O75976,P02786,P55786,Q9UIQ6,P09960,O75844,Q9NY33,Q9NZ08 8 +Glycosphingolipid binding 0.9173683996761814 1.821639997743394 0.0685096277646319 1.0 0.5036430904787771 3 Q9UM22 1 +Ganglioside binding 0.9173683996761814 1.821639997743394 0.0685096277646319 1.0 0.5036430904787771 3 Q9UM22 1 +Voltage gated channel activity 0.6953518468125115 1.8073974454472097 0.0707003319806873 1.0 0.5036430904787771 9 P45880,P21796,P51790 3 +Solute cation symporter activity 0.7843062926459403 1.7963369813329249 0.0724409397249203 1.0 0.5036430904787771 6 P55011,Q96ES6,Q00325,Q9Y6M7,Q96QD8 5 +Purine nucleotide transmembrane transporter activity 0.7226085015946403 1.789621234177736 0.0735148225184543 1.0 0.5036430904787771 8 P12235,Q8TB61,P12236,P05141,Q99808,Q6NUK1 6 +Iron ion binding 0.5737571872207243 1.7884206042329074 0.0737081745464858 1.0 0.5036430904787771 21 Q9NWT6,O75845,Q32P28,Q16850,Q6UW02,Q9BV57 6 +Sterol transfer activity 0.8287244157327028 1.7843078223064617 0.0743736598715902 1.0 0.5036430904787771 4 P61916 1 +Neutral amino acid transmembrane transporter activity 0.7907709685050907 1.781297460448681 0.0748638691554806 1.0 0.5036430904787771 5 Q96QD8,Q15758,P08195 3 +Nadp binding 0.5793545942048159 1.7724720304080388 0.0763162341823648 1.0 0.5036430904787771 17 P48163,Q13423,P35270,Q14739,O75874,Q9UBM7 6 +Palmitoyltransferase activity 0.8246682297155463 1.7675958961922955 0.0771284845774169 1.0 0.5036430904787771 4 P23786,O15269 2 +High density lipoprotein particle binding 0.9009628180736268 1.7562040808010675 0.0790535681676662 1.0 0.5036430904787771 3 Q9BQE5 1 +L amino acid transmembrane transporter activity 0.7422468383152435 1.742015821087783 0.0815056758969683 1.0 0.5036430904787771 7 Q9Y619,Q96QD8,P08195 3 +Glucosidase activity 0.7793600134732148 1.7332321538026318 0.0830544141740936 1.0 0.5036430904787771 5 P10253 1 +Dioxygenase activity 0.5900724930502023 1.7328725845186916 0.0831183180670827 1.0 0.5036430904787771 15 P13674,Q9NWT6,Q9BV57,Q32P28 4 +P type transmembrane transporter activity 0.7790829859795413 1.7320628259576856 0.083262377026704 1.0 0.5036430904787771 5 P05026,P05023,P35670,P16615 4 +Growth factor receptor binding 0.5887426511686946 1.7250110547561572 0.0845254803003383 1.0 0.5036430904787771 15 Q92542,O00560,Q9H2J4,P05067 4 +Transmembrane receptor protein kinase activity 0.8913290420295388 1.7176701939542791 0.0858567889341164 1.0 0.5036430904787771 3 P11717,Q15375 2 +Transmembrane receptor protein tyrosine kinase activity 0.8913290420295388 1.7176701939542791 0.0858567889341164 1.0 0.5036430904787771 3 P11717,Q15375 2 +Sulfur compound transmembrane transporter activity 0.7707235979418671 1.6967251087857684 0.0897486433282035 1.0 0.5036430904787771 5 Q70HW3,Q8TB61 2 +Thiolester hydrolase activity 0.5983988235040792 1.6844583132152475 0.0920931293451343 1.0 0.5036430904787771 13 P50897,Q9NUJ1 2 +Galactoside binding 0.9863739591218772 1.6813851798870303 0.0926881222697173 1.0 0.5036430904787771 2 P06280 1 +Galactosidase activity 0.9863739591218772 1.6813851798870303 0.0926881222697173 1.0 0.5036430904787771 2 P06280 1 +Sulfatide binding 0.8817783769323606 1.679396987874079 0.0930746999450262 1.0 0.5036430904787771 3 P50897 1 +Primary active transmembrane transporter activity 0.5344173165323511 1.6783802705020616 0.0932728866745908 1.0 0.5036430904787771 43 O96000,P05026,Q15388,P51798,P31930,Q9UDW1,O43674,P98194,P00403,O75306,O43676,P05023,Q9HD20,P61421,P20674,P16615,P08183,P35670 18 +Single stranded dna exodeoxyribonuclease activity 0.8811543368842587 1.6768938849122548 0.093563234152517 1.0 0.5036430904787771 3 Q8IV08 1 +Oxidoreductase activity acting on other nitrogenous compounds as donors cytochrome as acceptor 0.8800856646051382 1.6726066674728868 0.0944047534719392 1.0 0.5036430904787771 3 O43169 1 +Nitrite reductase activity 0.8800856646051382 1.6726066674728868 0.0944047534719392 1.0 0.5036430904787771 3 O43169 1 +Transition metal ion transmembrane transporter activity 0.7643046608563884 1.66952216341933 0.0950139417507023 1.0 0.5036430904787771 5 Q8TAD4,P35670,P98194,Q9HD20 4 +Volume sensitive anion channel activity 0.9829674489023464 1.6674519887092587 0.0954245635884321 1.0 0.5036430904787771 2 Q9C0H2 1 +Lysophosphatidic acid binding 0.9776684330052984 1.6457707901033032 0.0998109582384998 1.0 0.5036430904787771 2 P50897 1 +Carbohydrate binding 0.5350187813317613 1.6386138592125925 0.1012937041222608 1.0 0.5036430904787771 40 P11717,P10253,O75503,O00462,P08236,P35613,Q5KU26,O00754 8 +Hexosyltransferase activity 0.5487163657383805 1.6361917715092564 0.1017994580301715 1.0 0.5036430904787771 28 Q10472,P04062,Q13126,Q8N6G5,Q16739,P07686,Q9BV10,Q9BT22,O43505,P06865 10 +Metal ion transmembrane transporter activity 0.5477071579660248 1.6212424527817233 0.1049656514418906 1.0 0.5036430904787771 22 P05026,P55011,Q8TAD4,P98194,P05023,Q9HD20,O95202,Q6P4Q7,Q8N4V1,Q9Y6M7,Q96QD8,P16615,P08195,P35670,Q9BXP2 15 +Dipeptidyl peptidase activity 0.786681796816538 1.6101699092841577 0.1073607685531266 1.0 0.5036430904787771 4 P42785 1 +2 acylglycerol 3 phosphate o acyltransferase activity 0.7852273451858142 1.60411226366209 0.1086893091511038 1.0 0.5036430904787771 4 Q96N66,Q6P1A2 2 +Amyloid beta binding 0.6542334848791493 1.604019919524622 0.1087096619177907 1.0 0.5036430904787771 9 Q9NQX7,Q8WTV0 2 +Potassium ion transmembrane transporter activity 0.7837121212121254 1.597799398975356 0.1100876284588681 1.0 0.5036430904787771 4 P05026,P55011,P05023 3 +Pattern recognition receptor activity 0.9655563966691898 1.5961873081485165 0.1104469803818759 1.0 0.5036430904787771 2 Q8WTV0 1 +Low density lipoprotein particle binding 0.9655563966691898 1.5961873081485165 0.1104469803818759 1.0 0.5036430904787771 2 Q8WTV0 1 +Acetylgalactosaminyltransferase activity 0.7829545454545479 1.5946423203070048 0.1107922431956405 1.0 0.5036430904787771 4 Q10472,Q8N6G5,Q10471 3 +Monosaccharide binding 0.5425114854538627 1.5870263555087354 0.1125066756182311 1.0 0.5036430904787771 24 P11717,O75503,O00462,P35613,Q5KU26 5 +Lipid transfer activity 0.7062630103438055 1.580298842844292 0.1140384447508098 1.0 0.5036430904787771 7 P30536,P61916 2 +Serine transmembrane transporter activity 0.7775061621004038 1.571921772032239 0.115968694589327 1.0 0.5069195934858943 4 Q96QD8,Q15758 2 +Lipopolysaccharide binding 0.7292567696669936 1.5606030027061586 0.1186174498628269 1.0 0.5105540722251128 6 Q8WTV0 1 +Isocitrate dehydrogenase activity 0.7701371634676966 1.5411513637949172 0.123279951382424 1.0 0.5182581420579264 4 P48735 1 +Organic cation transmembrane transporter activity 0.724530776573328 1.5401463454930513 0.1235246849867388 1.0 0.5182581420579264 6 Q70HW3,O43772 2 +Phosphatidylserine binding 0.6152646755799122 1.53842655107347 0.1239443544756611 1.0 0.5183836209202178 10 Q14108,Q06481 2 +Solute sodium symporter activity 0.8398333964407478 1.5106386502142064 0.1308805409832749 1.0 0.5314936203004981 3 Q9Y6M7,Q96QD8 2 +Demethylase activity 0.6634890123727764 1.5103928413845888 0.130943214179253 1.0 0.5314936203004981 8 Q16850 1 +Hormone binding 0.6888206277334505 1.5011079072006868 0.133327653976786 1.0 0.5314936203004981 7 P30536,P42892 2 +5 3 exodeoxyribonuclease activity 0.9409538228614676 1.49542507032253 0.1348035416854234 1.0 0.5320139775715523 2 Q8IV08 1 +2 oxoglutarate dependent dioxygenase activity 0.5726545504994497 1.492079229893151 0.1356783761360331 1.0 0.5338823676358702 12 Q9NWT6,Q32P28 2 +Solute cation antiporter activity 0.8316469274310407 1.477613201699674 0.1395113387289908 1.0 0.5432772812690575 3 P51790 1 +Solute anion antiporter activity 0.7537878787878818 1.472734781301476 0.1408225641549338 1.0 0.5432772812690575 4 P12235,Q02978,P12236 3 +Beta 2 microglobulin binding 0.933762301286903 1.4659796012502415 0.1426538441969174 1.0 0.5432772812690575 2 P55899 1 +Atp transmembrane transporter activity 0.70621683093252 1.4605854946820496 0.1441292293915674 1.0 0.5432772812690575 6 P12235,P12236,P05141,Q86VD7,Q6NUK1 5 +Transferase activity transferring sulphur containing groups 0.8243089738735381 1.447998068659824 0.147617590731568 1.0 0.5454991459462077 3 Q2VPK5,Q8NCH0 2 +O acyltransferase activity 0.5722256727893182 1.4477828863029043 0.147677780421402 1.0 0.5454991459462077 11 P23786,Q8NCC3,Q9HCL2,Q96N66 4 +Peptidyl proline dioxygenase activity 0.8214772979412406 1.436567623095205 0.1508408888091601 1.0 0.5454991459462077 3 Q32P28 1 +Procollagen proline dioxygenase activity 0.8214772979412406 1.436567623095205 0.1508408888091601 1.0 0.5454991459462077 3 Q32P28 1 +Cytoskeletal anchor activity 0.7430186383868858 1.4275766097473916 0.15341376001255 1.0 0.5494989413811623 4 Q9UQB8 1 +Adp transmembrane transporter activity 0.7059492231906057 1.419840180205271 0.1556542143916934 1.0 0.5520536137092061 5 P12235,Q86VD7,P05141,P12236 4 +C4 dicarboxylate transmembrane transporter activity 0.7032795867069002 1.4083320218401552 0.1590327778941749 1.0 0.5571225590379865 5 Q9UBX3,Q02978,Q15758 3 +Dicarboxylic acid transmembrane transporter activity 0.7032795867069002 1.4083320218401552 0.1590327778941749 1.0 0.5571225590379865 5 Q9UBX3,Q02978,Q15758 3 +Nadplus binding 0.7361100659737283 1.3985771934124125 0.1619398094014745 1.0 0.5594284324778213 4 Q16836,P00367 2 +Small molecule sensor activity 0.6978598321968891 1.3849510728276724 0.1660674286062113 1.0 0.5663325129391311 5 Q9NWT6 1 +Oxidoreductase activity acting on a heme group of donors 0.7223484848484888 1.3407624089835686 0.1799976046548075 1.0 0.5972626357184254 4 P00403,P20674,P16435 3 +Phospholipid transporter activity 0.6873709299963369 1.339641319916208 0.180361983475886 1.0 0.5972626357184254 5 Q96GC9,Q9Y5P4 2 +Atpase coupled transmembrane transporter activity 0.5037335925392233 1.3391372382345486 0.1805259996682759 1.0 0.5972626357184254 20 P05026,Q15388,P51798,P05023,P98194,Q9HD20,P61421,P16615,P08183,P35670 10 +Branched chain amino acid transmembrane transporter activity 0.8951551854655543 1.3082539043511865 0.1907872042227085 1.0 0.6089070389947714 2 Q96H78 1 +Intramembrane lipid transporter activity 0.8940196820590456 1.3036294417062793 0.1923599572882741 1.0 0.6093511934382028 2 Q96GC9 1 +Oxidoreductase activity acting on the ch ch group of donors oxygen as acceptor 0.7858424451992397 1.292766355072783 0.1960918801741185 1.0 0.6165536657956917 3 Q15067 1 +Ephrin receptor binding 0.6418448831147954 1.2856884354839244 0.1985518188280055 1.0 0.6228158467953947 7 O00560,Q15375,P46108 3 +Polypeptide n acetylgalactosaminyltransferase activity 0.782658084059069 1.279933250392116 0.2005686124058021 1.0 0.6244026949607884 3 Q10472,Q10471 2 +Oxidoreductase activity acting on nad p h heme protein as acceptor 0.7771433997231343 1.2577214681048234 0.2084925054638313 1.0 0.6368241479497315 3 P16435 1 +Cytochrome b5 reductase activity acting on nad p h 0.7771433997231343 1.2577214681048234 0.2084925054638313 1.0 0.6368241479497315 3 P16435 1 +Chemoattractant activity 0.7016327984127035 1.2536861352838482 0.2099561093388369 1.0 0.6368241479497315 4 P14174,P26583 2 +Oxygen binding 0.7001801360043968 1.247581282210662 0.2121844366675644 1.0 0.6368241479497315 4 Q9NWT6 1 +Lysophospholipase activity 0.7000360078943646 1.2469756050568952 0.2124064425751848 1.0 0.6368241479497315 4 Q8NCC3 1 +Chloride channel inhibitor activity 0.8796366389099166 1.245160548140379 0.2130727412313011 1.0 0.6368241479497315 2 O15400 1 +Poly g binding 0.6558393542133589 1.2398074854101129 0.2150466088981193 1.0 0.6384196201662917 6 Q06787 1 +Translation repressor activity 0.6293742356987442 1.2280983658607816 0.2194100444098097 1.0 0.6413357265449574 7 P04818,Q14011,P34896,Q06787 4 +L serine transmembrane transporter activity 0.7688728977161908 1.224445965520368 0.2207840383646926 1.0 0.64163382353887 3 Q96QD8 1 +Coreceptor activity 0.7663125798004189 1.2141550275497683 0.2246885302030759 1.0 0.6454335748814058 3 O14786 1 +Protein self association 0.524056205153233 1.210396188330496 0.2261269038169318 1.0 0.6458145989320057 12 P53634,Q9Y282 2 +Sphingolipid transporter activity 0.7637674997952241 1.2039307174631513 0.2286163580069127 1.0 0.6494551910728341 3 Q9Y5P4 1 +17 beta hydroxysteroid dehydrogenase nadpplus activity 0.8671461014383022 1.1945781971637082 0.2322518719030943 1.0 0.6515019803494146 2 Q8NBQ5 1 +Leukotriene c4 synthase activity 0.8667676003028011 1.1930486697118523 0.2328503126656342 1.0 0.6515019803494146 2 Q99735 1 +Oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen nad p h as one donor and incorporation of one atom of oxygen 0.8641180923542733 1.182347826351096 0.2370677159341574 1.0 0.659623561072028 2 Q16850 1 +5 3 exonuclease activity 0.6167052390537493 1.169483074696334 0.2422090564957653 1.0 0.6620417022845694 7 Q8IV08 1 +Rna strand annealing activity 0.6474752298475044 1.1668674028318278 0.2432639217616827 1.0 0.6620417022845694 5 Q06787 1 +Oxidoreductase activity acting on diphenols and related substances as donors 0.7538811056418183 1.164271646064219 0.2443139433132315 1.0 0.6620417022845694 3 P31930,Q9UDW1 2 +Ubiquinol cytochrome c reductase activity 0.7538811056418183 1.164271646064219 0.2443139433132315 1.0 0.6620417022845694 3 P31930,Q9UDW1 2 +Phosphate ion binding 0.6465393949912601 1.1628123328613638 0.2449056522736903 1.0 0.6620417022845694 5 P30520 1 +Atpase coupled cation transmembrane transporter activity 0.494763679765039 1.154561478860716 0.2482700489604976 1.0 0.6684193625859551 15 P05026,P05023,Q9HD20,P61421,P16615,P35670 6 +Glucosyltransferase activity 0.6346550629430596 1.146433127318101 0.2516159822227042 1.0 0.6699511662810006 6 Q16739 1 +Camp dependent protein kinase regulator activity 0.7486699639028178 1.1434090757359925 0.2528687860699716 1.0 0.6699511662810006 3 P10644 1 +Glycosyltransferase activity 0.4721872377527344 1.141250261661308 0.2537657938011721 1.0 0.6709910651203955 37 Q10472,P04062,P43490,Q13126,Q8N6G5,Q16739,P07686,Q9BV10,Q9BT22,O43505,P06865 11 +C palmitoyltransferase activity 0.8531415594246778 1.1381329258508344 0.2550649812557055 1.0 0.6717552971684918 2 O15269 1 +Passive transmembrane transporter activity 0.4745052655626685 1.1304128833179674 0.2583022879645855 1.0 0.6781653885694929 31 P45880,P51790,P21796,Q9C0H2 4 +Oxygen sensor activity 0.7444810464476135 1.1266627653630583 0.259885090909852 1.0 0.6790710626917548 3 Q9NWT6 1 +Modified amino acid binding 0.4681055470806881 1.1150156850347186 0.2648437003396298 1.0 0.6852687211205408 18 Q14108,Q06481,Q8WTV0,Q9H7Z7 4 +Pdz domain binding 0.581033979650355 1.1114057091818097 0.2663937559881533 1.0 0.6853069544762938 8 P51790,Q9UQB8 2 +Cysteine type endopeptidase activity 0.4660345303874785 1.089610877569384 0.2758845894432453 1.0 0.6926963101764149 20 Q99538,P07858 2 +Voltage gated chloride channel activity 0.8398940196820549 1.0850565816207454 0.2778965958513963 1.0 0.6926963101764149 2 P51790 1 +Metalloaminopeptidase activity 0.5289928687759319 1.0737553265131887 0.2829323571205189 1.0 0.6982716289268392 10 P09960,P55786,Q9NZ08,Q9UIQ6 4 +Palmitoyl coa hydrolase activity 0.6255703940572128 1.0720261375477729 0.2837082924482761 1.0 0.6982716289268392 5 P50897 1 +Solute proton symporter activity 0.8357305071915213 1.0684489795634682 0.2853180331883469 1.0 0.699051450198218 2 Q96ES6 1 +Oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen reduced flavin or flavoprotein as one donor and incorporation of one atom of oxygen 0.8277819833459477 1.0368523369703433 0.2998046798528184 1.0 0.7120361146504534 2 P30519 1 +Phospholipase d activity 0.8277819833459457 1.0368523369703349 0.2998046798528224 1.0 0.7120361146504534 2 Q8IV08 1 +G protein activity 0.4995166577653107 1.0310553010203278 0.3025148874551173 1.0 0.7122346140620145 11 P11233 1 +L glutamine transmembrane transporter activity 0.8255109765329277 1.027852538931726 0.3040191978388793 1.0 0.7143914012821723 2 Q96QD8 1 +Sulfurtransferase activity 0.8239969719909128 1.0218598699247357 0.3068472282252443 1.0 0.7187187897928414 2 Q2VPK5 1 +Poly purine tract binding 0.4785254079373169 1.014734527389928 0.3102323907997739 1.0 0.7200856540378697 14 O14979,Q06787 2 +Calmodulin dependent protein kinase activity 0.7129875047330612 1.0016323853420406 0.316521173709823 1.0 0.7226597453434643 3 Q14012,P46020 2 +Histone methyltransferase activity 0.4884236305231333 1.0011073522358545 0.3167749109287516 1.0 0.7226597453434643 12 O96028,Q03164,Q9BV86,Q9H7B4 4 +P type potassium transmembrane transporter activity 0.8152914458743349 0.9875193574719436 0.3233880980297843 1.0 0.7264741491764866 2 P05026 1 +Structural constituent of eye lens 0.7069291934873156 0.9778010581756624 0.3281727275835768 1.0 0.7264741491764866 3 Q99797,P36551 2 +Cysteine type peptidase activity 0.4479053622761803 0.971369358199602 0.3313643815976221 1.0 0.7264741491764866 39 Q92820,Q99538,Q96FW1,P07858 4 +O methyltransferase activity 0.5732110398323828 0.9680534774876222 0.3330176625445373 1.0 0.7264741491764866 7 P21964,O60725 2 +Protease binding 0.4481987586215059 0.9647056022914148 0.3346922884222441 1.0 0.7268833784933046 21 O75955,P07602,P46379,Q9NZJ7,Q9BUN8 5 +Ionotropic glutamate receptor binding 0.5996898735540657 0.9604293769841848 0.3368391588961936 1.0 0.7268833784933046 5 Q13501 1 +Mrna 3 utr au rich region binding 0.5254485718087425 0.9473383738300084 0.3434663827539106 1.0 0.7333810641824083 9 Q14103,Q01085,Q92945 3 +17 beta hydroxysteroid dehydrogenase nadplus activity 0.6207707549464644 0.9165717235818928 0.3593671072587514 1.0 0.7411074544474945 4 Q8NBQ5 1 +Estradiol 17 beta dehydrogenase activity 0.6207707549464644 0.9165717235818928 0.3593671072587514 1.0 0.7411074544474945 4 Q8NBQ5 1 +Cullin family protein binding 0.5892813605031997 0.9157990208336744 0.3597723171799671 1.0 0.7411074544474945 5 Q9NXV2,Q92564,P63208 3 +Histone h3 methyl lysine 4 demethylase activity 0.6892483972394545 0.908775562332638 0.3634686086517891 1.0 0.7425702757402143 3 Q8NB78 1 +Proton transmembrane transporter activity 0.4408660744059811 0.8912104182987164 0.3728162962685235 1.0 0.7493458275053277 33 P12235,Q9Y487,P24539,Q13423,Q9UDW1,P51790,Q96ES6,Q00325,Q93050,O75964 10 +Sulfuric ester hydrolase activity 0.6828740934440817 0.8841082112569713 0.376637801019021 1.0 0.7493458275053277 3 P15586 1 +N6 methyladenosine containing rna binding 0.573655830453171 0.8780566848659592 0.3799129576760207 1.0 0.7530316448719935 6 Q9Y5A9,P22626 2 +Anion cation symporter activity 0.7831188493565462 0.8626450464359732 0.3883326551573787 1.0 0.7565587006486706 2 P55011 1 +Potassium chloride symporter activity 0.7831188493565462 0.8626450464359732 0.3883326551573787 1.0 0.7565587006486706 2 P55011 1 +Cation chloride symporter activity 0.7831188493565462 0.8626450464359732 0.3883326551573787 1.0 0.7565587006486706 2 P55011 1 +Mitochondrial ribosome binding 0.5753775618475544 0.8565067425475432 0.3917175449305867 1.0 0.7565587006486706 5 Q07021 1 +P type calcium transporter activity 0.7781983345950019 0.8438777514594624 0.3987377219064421 1.0 0.7570284369171165 2 P16615 1 +Manganese ion transmembrane transporter activity 0.7781983345950004 0.8438777514594564 0.3987377219064454 1.0 0.7570284369171165 2 Q9HD20 1 +N acyltransferase activity 0.4446962755249932 0.8428509782451474 0.3993117930148049 1.0 0.7570284369171165 15 Q86UY6,Q96G23,Q9H9T3 3 +L aspartate transmembrane transporter activity 0.6717152593714515 0.841245245769627 0.4002105578425889 1.0 0.7570284369171165 3 Q9UJS0,Q15758 2 +Acidic amino acid transmembrane transporter activity 0.6717152593714515 0.841245245769627 0.4002105578425889 1.0 0.7570284369171165 3 Q9UJS0,Q15758 2 +Succinate transmembrane transporter activity 0.7774413323239941 0.8409992811438713 0.4003483371307177 1.0 0.7570284369171165 2 Q9UBX3 1 +Sulfate transmembrane transporter activity 0.7774413323239941 0.8409992811438713 0.4003483371307177 1.0 0.7570284369171165 2 Q9UBX3 1 +Mrna 3 utr binding 0.4287142832939272 0.8373063699598638 0.4024203796243619 1.0 0.7570284369171165 41 Q14103,Q01085,P35637,Q9BWF3,Q14011,Q92945,P51116,P22626,Q92804,P51114,Q06787 11 +Steroid dehydrogenase activity 0.5609876560701147 0.8228411879757896 0.4105983108824014 1.0 0.7630079252474515 6 Q3SXM5,Q8NBQ5 2 +Pre mrna intronic binding 0.5647136591424757 0.8113449492295034 0.4171676037228082 1.0 0.766343802418971 5 P22626 1 +Fk506 binding 0.5578739989875188 0.809320302411042 0.4183309311622905 1.0 0.7663638270603943 6 P62942,Q9Y680 2 +Macrolide binding 0.5578739989875188 0.809320302411042 0.4183309311622905 1.0 0.7663638270603943 6 P62942,Q9Y680 2 +Mannosyltransferase activity 0.5615487667207653 0.7980029083058373 0.4248688023958458 1.0 0.7719610753913592 5 Q9BV10,Q9BT22 2 +Translation initiation factor binding 0.431097873332971 0.7934313276557333 0.4275265645742276 1.0 0.7729727892218275 16 P55010,Q06787 2 +Transmembrane transporter binding 0.4255311349404894 0.7910422704884685 0.4289193251221319 1.0 0.7729727892218275 25 P30536,P21796 2 +Mirna binding 0.4524227735330111 0.7893448204975408 0.429910497121972 1.0 0.7729727892218275 12 Q9NY93,Q9BWF3,P43243,P22626,Q06787 5 +Magnesium ion transmembrane transporter activity 0.7634367903103685 0.7881981561587323 0.4305808074811901 1.0 0.7729727892218275 2 Q6P4Q7 1 +Flavin adenine dinucleotide binding 0.4222589378476672 0.7684292436194113 0.4422322122081246 1.0 0.782147430225744 25 O95831,Q14534,Q15067,Q15392,Q8NB78,P16435 6 +Quaternary ammonium group transmembrane transporter activity 0.7577592732778157 0.767051501356451 0.4430508955524708 1.0 0.782147430225744 2 O43772 1 +Rage receptor binding 0.648550796393714 0.753779921337301 0.4509813824503554 1.0 0.7902572314347467 3 P26583 1 +Nucleobase transmembrane transporter activity 0.7532172596517761 0.7502497870758884 0.4531042783689663 1.0 0.7911027146604273 2 P12235 1 +Oxidative phosphorylation uncoupler activity 0.7532172596517761 0.7502497870758884 0.4531042783689663 1.0 0.7911027146604273 2 P12235 1 +Calcium cation antiporter activity 0.7528387585162721 0.7488544262102712 0.4539449513822675 1.0 0.7911027146604273 2 P08195 1 +Cation cation antiporter activity 0.7528387585162721 0.7488544262102712 0.4539449513822675 1.0 0.7911027146604273 2 P08195 1 +Oxidoreductase activity acting on single donors with incorporation of molecular oxygen 0.7520817562452657 0.7460659474365141 0.4556275785187123 1.0 0.7911027146604273 2 Q9BV57 1 +Endoribonuclease activity 0.4141187840522402 0.742212051233443 0.4579588681012978 1.0 0.7930798106441745 20 O00584,Q9UQ84 2 +Organic hydroxy compound transmembrane transporter activity 0.7490537471612378 0.7349422925984105 0.4623746398395645 1.0 0.793963619838735 2 P53985 1 +Membrane insertase activity 0.5463758796677143 0.734493575987746 0.4626479739661802 1.0 0.793963619838735 5 Q15070,Q9NPA0 2 +Acylglycerol o acyltransferase activity 0.5214695815616766 0.7308563286377174 0.4648669132291123 1.0 0.7955875014991952 7 Q8NCC3,Q96N66 2 +Poly pyrimidine tract binding 0.4318882900803649 0.7300022994182898 0.4653887790724615 1.0 0.7955875014991952 14 Q07666,P31943,P07910,Q06787 4 +Lipase activity 0.4199116043536456 0.7225711393349442 0.4699434047199102 1.0 0.7972254187212764 16 Q8NHP8,Q8N2A8,Q8NCC3,Q8IV08,Q9H6V9 5 +Poly a binding 0.4622857151057093 0.7118118480423157 0.4765812949275005 1.0 0.8023457243716149 10 O14979 1 +Sh2 domain binding 0.4783459543622221 0.706782528075927 0.4797016339363278 1.0 0.806577968565507 9 Q13501,P46108 2 +Abc type transporter activity 0.5671710745945231 0.7011986047801884 0.4831790804436044 1.0 0.8103760113366886 4 Q9HD20 1 +Folic acid binding 0.736563209689626 0.6895928123264343 0.4904502887067528 1.0 0.8133402543391287 2 P04818 1 +Monocarboxylic acid transmembrane transporter activity 0.5349408976090934 0.6872044689130774 0.491953888614328 1.0 0.8138043182301693 5 P53985,O14975 2 +Protein tyrosine kinase activity 0.4394899568529239 0.6853157607843752 0.493144688389882 1.0 0.8140504246731017 11 P11717,Q15375 2 +Peptidase regulator activity 0.4115613118922842 0.678551969309447 0.4974217846324726 1.0 0.8156705429849691 30 Q06481,P05067 2 +Carboxylic acid binding 0.4105722857129586 0.6714908789920879 0.501907868047446 1.0 0.8175825020406873 30 P11717,Q9UM22,Q9NWT6,P07602 4 +C methyltransferase activity 0.6205711509799148 0.6515088828147391 0.5147180448968021 1.0 0.8257840768549418 3 Q96P11 1 +Deoxyribonuclease activity 0.4118812509439077 0.6395305805128049 0.5224778263442786 1.0 0.8332080444099408 15 Q8IV08,O00115 2 +Oxidoreductase activity acting on nad p h 0.3979519115867759 0.6011560427067053 0.5477360590659233 1.0 0.8504301268149957 25 O96000,O95831,O43674,O75306,O43676,Q13423,P16435 7 +Mhc protein complex binding 0.4743492092217393 0.5972677065139526 0.550328661469915 1.0 0.8530735661480034 8 P05026,Q9NUQ9 2 +Calcium ion binding 0.3271593807298622 0.5874682889376994 0.5568892419098168 1.0 0.8597747419084514 77 Q14126,Q9UM22,O94813,P80303,Q14257,O43852,Q9Y680,Q02818,Q14574 9 +Endodeoxyribonuclease activity 0.4541666887762108 0.5859160841494278 0.5579319081082141 1.0 0.8597747419084514 9 O00115 1 +Minor groove of adenine thymine rich dna binding 0.5368100001039834 0.5850732504203461 0.5584984643339326 1.0 0.8597747419084514 4 Q14103 1 +Electron transfer activity 0.3954081587736502 0.5817625214714255 0.5607266519408092 1.0 0.8597747419084514 42 O96000,P48163,P14406,O43674,Q9UDW1,O75306,O43676,P00403,P20674,P16435 10 +N acetyltransferase activity 0.4117701887558557 0.5802550901326323 0.5617426079707495 1.0 0.8597747419084514 13 Q86UY6,Q96QD8,Q9UKN8,Q9H9T3 4 +Protein methyltransferase activity 0.3881347695460387 0.5782580658588987 0.5630899013219008 1.0 0.8597747419084514 19 O60725,Q9BV86,Q9H7B4 3 +L ascorbic acid binding 0.5347365726304029 0.5773516396518049 0.5637019360482478 1.0 0.8597747419084514 4 Q32P28 1 +Misfolded protein binding 0.4357902879180549 0.5711469624892014 0.5679000267665941 1.0 0.8632690617347767 10 P46379,Q9BUN8 2 +C acyltransferase activity 0.4504153507566645 0.5674240932103113 0.5704260846366307 1.0 0.8632690617347767 9 Q9BWD1,O15269,O15270 3 +Nad binding 0.3914813881470645 0.5569862866710189 0.5775367986576208 1.0 0.8667895233433255 25 P48163,Q16836,O75306,Q13423,O75874,P48735 6 +Aminopeptidase activity 0.4069752368588407 0.5523028477326078 0.5807408798588556 1.0 0.8667895233433255 13 P09960,P55786,Q9NZ08,Q9UIQ6 4 +Calcium channel regulator activity 0.5892698148368477 0.5427298752206989 0.5873158014658897 1.0 0.8667895233433255 3 P62942 1 +Enzyme activator activity 0.3314251044291 0.5285433240915072 0.597122285434375 1.0 0.8746394709556373 85 O14786,Q9H0H5,P10619,Q5JRX3,O00429,P07602,O43169,P05067,Q99735,P53634,O75569,Q9NZJ7,P17900 13 +Chloride channel regulator activity 0.5807097568326293 0.5142256790509627 0.6070942162136572 1.0 0.8758064571661578 3 O15400 1 +Annealing activity 0.4561144726473797 0.5131788009040542 0.6078262534917882 1.0 0.8758064571661578 8 Q06787 1 +Oxidoreductase activity acting on the ch ch group of donors 0.3808032989103366 0.4978762619354457 0.6185712596330699 1.0 0.8798928078203027 23 Q15067,Q15392,Q14739,Q8N4Q0,Q9UBM7 5 +Oxidoreductase activity acting on the ch ch group of donors nad or nadp as acceptor 0.3998102517339345 0.4862257798500829 0.6268070951470559 1.0 0.8868653580272174 12 Q14739,Q9UBM7,Q8N4Q0,Q15392 4 +Oligopeptide binding 0.5093061334022718 0.485253775155805 0.6274963407604084 1.0 0.8868970597357525 4 Q9H7Z7 1 +Lysine n methyltransferase activity 0.4769195285971419 0.4703789631884019 0.6380842911857596 1.0 0.8924392421661752 6 Q9H7B4,Q03164 2 +Histone lysine n methyltransferase activity 0.4769195285971419 0.4703789631884019 0.6380842911857596 1.0 0.8924392421661752 6 Q9H7B4,Q03164 2 +Glutamate receptor binding 0.4602996635936625 0.462576891494263 0.6436676756917732 1.0 0.8936096123904576 7 Q13501 1 +Cell cell adhesion mediator activity 0.381143324981229 0.4533909853668821 0.650267226529089 1.0 0.9008910534205088 15 Q14126,Q9UQB8 2 +Chemokine binding 0.6619984859954526 0.4415544923784602 0.6588116208922672 1.0 0.90204233994091 2 P05556 1 +Phosphoprotein binding 0.3705405802938315 0.4377875100196095 0.6615403258477648 1.0 0.90204233994091 22 Q9Y4P3,P11717,P46108 3 +Histone arginine n methyltransferase activity 0.5558500567966655 0.4349867984996397 0.6635720098516731 1.0 0.9024036534792692 3 O14744,Q86X55 2 +Phosphotransferase activity for other substituted phosphate groups 0.5515594047014993 0.4218896413495835 0.6731055712624108 1.0 0.9053315540900736 3 P48651 1 +Endoribonuclease activity producing 5 phosphomonoesters 0.3878523560061164 0.4197804308819307 0.6746458618972233 1.0 0.9053315540900736 12 Q9UQ84 1 +G protein beta gamma subunit complex binding 0.4661165663881831 0.418405862178364 0.6756504012304259 1.0 0.9053315540900736 5 P04899 1 +Cytokine receptor binding 0.3617802497631505 0.4180158705670057 0.6759355136928145 1.0 0.9053315540900736 18 P62942,P62993,P14174,O00560,Q9H2J4,Q9NZ08 6 +Endopeptidase regulator activity 0.370530718286199 0.4158004861640119 0.677556003085086 1.0 0.905677873470517 25 P05067 1 +3 hydroxyacyl coa dehydrogenase activity 0.4611984408232712 0.4089785502435146 0.6825554024166915 1.0 0.9096179210563125 6 Q53GQ0,Q16836 2 +Cell adhesion mediator activity 0.3610711043942997 0.3855960239970304 0.6997958783258051 1.0 0.9221883354282804 17 Q14126,Q9UQB8 2 +Steroid dehydrogenase activity acting on the ch oh group of donors nad or nadp as acceptor 0.4545281518709033 0.3768377720983089 0.706294168447732 1.0 0.925040532179594 5 Q8NBQ5 1 +Signaling receptor binding 0.382338693766281 0.3711847291539969 0.7104999463406068 1.0 0.925040532179594 148 Q9NWT6,Q15375,O94813,O60879,Q9BQE5,P06280,P05067,Q13501,O14654,Q9H2J4,Q9NZ08,P62993,P43490,P01889,P46108,Q9UMX5,P04439,P46379,Q9BUN8,P04062,P11233,O00560,Q92896,Q9NUQ9,O75955,P08236,Q07021,P78310,Q92542,P04899 30 +Scaffold protein binding 0.3575255786629822 0.3640048508358696 0.7158543870749816 1.0 0.9283232424777436 17 P07602 1 +Acyltransferase activity 0.363657604369793 0.3542261423521464 0.7231694133426196 1.0 0.9310893705185712 46 Q86UY6,P23786,Q92604,O15270,Q96N66,Q8IVS2,Q8NCC3,O15269,Q9UKN8,Q969G3,P40939,Q96QD8,Q96G23,Q6P1A2,Q9BWD1,Q9HCL2,Q9H9T3 17 +Mhc protein binding 0.4171319187533006 0.3418899158309187 0.7324337388596311 1.0 0.934872238659606 8 Q9NUQ9,Q9BUN8 2 +Pentosyltransferase activity 0.3718729511088932 0.3150473969447986 0.7527256672720812 1.0 0.9453495160263156 11 P43490 1 +Protein demethylase activity 0.4356205116715674 0.3120656579189332 0.7549906251490934 1.0 0.94729556169609 5 Q8NB78 1 +Single stranded rna binding 0.3613145610379528 0.3111327664523329 0.7556996924507906 1.0 0.94729556169609 35 Q96DH6,P31943,O14979,Q71RC2,P52597,O60306,Q07666,Q96EP5,P07910,Q96KR1,P26368,P09651,P51114,Q06787 14 +Regulatory rna binding 0.3574740847532442 0.294663519441715 0.768250933694568 1.0 0.9542694266872838 14 Q9NY93,Q9BWF3,P43243,P22626,Q06787 5 +Endonuclease activity 0.3566096557940157 0.2778682986253014 0.7811134599531426 1.0 0.9616049693425208 35 O00584,O00115,Q9UQ84 3 +Nucleobase containing compound kinase activity 0.3539915247820041 0.2756558065482192 0.7828124421415366 1.0 0.9616049693425208 14 Q9Y5B8,Q5KU26 2 +Carbon sulfur lyase activity 0.4230190053094374 0.2712389659440715 0.7862072453825741 1.0 0.9624090296525156 5 O14880,Q99735 2 +Endonuclease activity active with either ribo or deoxyribonucleic acids and producing 5 phosphomonoesters 0.3525265883022268 0.2677150821207886 0.7889186396015015 1.0 0.9626254960275202 14 Q9UQ84 1 +Translation repressor activity mrna regulatory element binding 0.415411243008853 0.2475822624868679 0.8044576360106199 1.0 0.9716069418254324 5 P04818,P00374,P34896 3 +Acyl coa binding 0.3810246679317021 0.2467119089311046 0.8051311894185351 1.0 0.9716069418254324 9 Q9H3P7,Q92947,O00154,O75521,P40939,P49748,Q02252,P22307 8 +Fatty acid derivative binding 0.3810246679317021 0.2467119089311046 0.8051311894185351 1.0 0.9716069418254324 9 Q9H3P7,Q92947,O00154,O75521,P40939,P49748,Q02252,P22307 8 +Lipase activator activity 0.5851627554882595 0.2425117889277144 0.8083836232103065 1.0 0.9729866234115002 2 Q9Y263 1 +Mhc class ii protein complex binding 0.3988950600051422 0.223015005817498 0.8235238276425687 1.0 0.977364241154594 7 P05026 1 +Exodeoxyribonuclease activity 0.3857980026407575 0.2161447654391562 0.8288749065612051 1.0 0.977364241154594 8 Q8IV08 1 +Phospholipase binding 0.4196969696969766 0.2133133149827597 0.8310825886962534 1.0 0.977364241154594 4 P20700,P84103,P07196 3 +Acetyl coa c acetyltransferase activity 0.4119886135804047 0.1947889397160264 0.8455581812687067 1.0 0.9841767073896928 4 Q9BWD1 1 +Chaperone binding 0.3451315188249039 0.1926691229477084 0.8472181066548763 1.0 0.9841767073896928 38 Q7L5D6,P01889,O43615,Q9UL15,P55011,P02786,P05023,P53634,Q14108 9 +Inositol tetrakisphosphate phosphatase activity 0.5598031794095304 0.192590165749262 0.8472799473392456 1.0 0.9841767073896928 2 Q9UNW1 1 +Phosphatidylinositol phosphate 4 phosphatase activity 0.5598031794095298 0.1925901657492605 0.8472799473392467 1.0 0.9841767073896928 2 Q9NTJ5 1 +Phosphoric diester hydrolase activity 0.342470355300145 0.1833481161776966 0.8545248829716166 1.0 0.9885395030462064 12 Q8IV08 1 +Phosphatidylinositol phosphate phosphatase activity 0.3909866127650572 0.1771380445720208 0.859399959172398 1.0 0.9888722437910809 5 Q10713 1 +Polyubiquitin modification dependent protein binding 0.3411602560136884 0.177009423174509 0.8595009878364581 1.0 0.9888722437910809 12 Q13501 1 +Oxidoreductase activity acting on ch or ch2 groups 0.5488266464799308 0.1735617786703979 0.8622098722423552 1.0 0.9911314866744446 2 P31350 1 +Phosphatidylinositol 3 kinase regulatory subunit binding 0.5476911430734207 0.171682249830667 0.863687341189497 1.0 0.9911384718758228 2 P22681 1 +Methylated histone binding 0.3177530825658509 0.1532781546369903 0.8781789271690608 1.0 1.0 18 O43159,Q9UFC0,Q9H2V7,P45973,P83916,Q06787 6 +C acetyltransferase activity 0.3801318125555404 0.1487226866220798 0.8817724589856744 1.0 1.0 5 Q9BWD1 1 +Ribonuclease p activity 0.4320333207118542 0.1441058688053655 0.8854168704603198 1.0 1.0 3 Q99575,O15091 2 +Ubiquitin specific protease binding 0.3713022184800816 0.1311278017837781 0.8956742084010587 1.0 1.0 7 Q9BUN8 1 +Rna polymerase binding 0.3182110581147056 0.1241282827573308 0.9012137049269312 1.0 1.0 21 P27105 1 +5 3 dna helicase activity 0.3776515151515259 0.1232376419069864 0.901918918810253 1.0 1.0 4 P18074,P51530,Q9Y265 3 +Acetylcholine receptor binding 0.5136260408781153 0.1229077726184365 0.9021801306377984 1.0 1.0 2 O15258 1 +Protein kinase a regulatory subunit binding 0.3722517058377496 0.1121887649574842 0.910673737195592 1.0 1.0 6 Q9H3P7,Q9ULX6,Q96M27,Q92667,O43823 5 +Phosphatidylinositol 4 phosphate binding 0.3565212599993534 0.1118568140233193 0.9109369390537964 1.0 1.0 8 P53365,Q9Y5P4 2 +Primary mirna binding 0.5030280090840191 0.1106390117546051 0.9119026104737742 1.0 1.0 2 P17844 1 +Protein homodimerization activity 0.3570263010157468 0.1044815721125058 0.9167871915580978 1.0 1.0 146 O95772,Q9NWT6,Q06481,P16278,O94813,Q8N2A8,P02786,P06280,P27105,P07602,Q15067,O75874,P42892,Q8TCT8,Q14108,Q06787 16 +Glucocorticoid receptor binding 0.4894019682058944 0.0967645544143332 0.9229133732773452 1.0 1.0 2 Q02790 1 +Oxidoreductase activity acting on nad p h quinone or similar compound as acceptor 0.3103817253800515 0.0906960908054077 0.9277340769160948 1.0 1.0 20 O75306,O43676 2 +Long chain acyl coa dehydrogenase activity 0.3801590306701987 0.081738708722568 0.9348544962231284 1.0 1.0 3 P49748,Q9NZ01 2 +Oxidative rna demethylase activity 0.4436033308099807 0.0639822774599529 0.9489843384282808 1.0 1.0 2 Q9C0B1 1 +Histone methyltransferase binding 0.3533698934716328 0.0639160287935627 0.9490370892439302 1.0 1.0 6 P83916,O95785 2 +Retinoid x receptor binding 0.4432248296744775 0.0637888734877833 0.949138337886424 1.0 1.0 2 P17096 1 +Ribonuclease p rna binding 0.4318697956093826 0.0584870012852408 0.9533607162423448 1.0 1.0 2 Q99575 1 +Mrna methyltransferase activity 0.3396474514637833 0.0543881948549821 0.9566258840753864 1.0 1.0 3 Q08J23 1 +Nadp retinol dehydrogenase activity 0.3286984873431565 0.0525846958371772 0.9580628110517172 1.0 1.0 4 Q8NBN7 1 +Armadillo repeat domain binding 0.4159727479182355 0.0525458446064842 0.958093767051917 1.0 1.0 2 Q9P1Z2 1 +Intermediate filament binding 0.3301779628928474 0.0501336722820658 0.9600158668650024 1.0 1.0 3 P48681,P08670 2 +Enoyl coa hydratase activity 0.3342175066313017 0.0500303115176388 0.9600982334621028 1.0 1.0 5 P51659,P40939,P42126,P30084 4 +Bh domain binding 0.4004542013625922 0.0481646515776327 0.9615850214304054 1.0 1.0 2 Q07820 1 +Death domain binding 0.4004542013625922 0.0481646515776327 0.9615850214304054 1.0 1.0 2 Q07820 1 +Bh3 domain binding 0.4004542013625922 0.0481646515776327 0.9615850214304054 1.0 1.0 2 Q07820 1 +Pre mrna binding 0.3003647590619681 0.0446990876472182 0.9643471609250004 1.0 1.0 17 P26368,P62995,Q01130,P09651,P22626,Q9BWF3 6 +G protein coupled serotonin receptor binding 0.3834216502649392 0.0446646798083096 0.9643745870170706 1.0 1.0 2 P08754 1 +Histone h3 methyl lysine 36 demethylase activity 0.3777441332323932 0.0437503882815597 0.9651033736009108 1.0 1.0 2 Q9H6W3 1 +Hexokinase activity 0.3050719152157387 0.0386802528548032 0.9691453175646784 1.0 1.0 2 P52789 1 +Proteasome binding 0.3077304910510733 0.0278448238125217 0.9777859155754108 1.0 1.0 12 Q92530,P46379,O95456 3 +Trna specific ribonuclease activity 0.2958333333333387 0.0240177871958488 0.9808384206687648 1.0 1.0 4 Q99575,O15091,P78346 3 +Phosphatidylinositol 3 kinase binding 0.3175445244410775 0.023056785381117 0.9816049767832244 1.0 1.0 5 P22681,P50570,P0DP25,O14654 4 +Phosphotyrosine residue binding 0.3305181736404255 0.0192235110352007 0.9846628019730648 1.0 1.0 7 P46108 1 +Aldo keto reductase nadp activity 0.3303746875409183 0.0188852967823606 0.9849326089184722 1.0 1.0 7 Q8NBN7,P35270 2 +Cyclin dependent protein serine threonine kinase regulator activity 0.2867424242424259 0.0183661010324246 0.9853467953364136 1.0 1.0 4 P11802,O95067,P14635 3 +Acetyl coa c acyltransferase activity 0.3316576621378575 0.0160940932816152 0.9871593257844312 1.0 1.0 6 Q9BWD1 1 +Trna guanine methyltransferase activity 0.2806818181818248 0.0150694267549129 0.9879767921074438 1.0 1.0 4 Q7Z2T5,Q7L0Y3,Q9BV44 3 +Supercoiled dna binding 0.3069344448654826 0.0083046093667707 0.993373956565387 1.0 1.0 5 P23396,P26583,O75475,P09429 4 +Dolichyl diphosphooligosaccharide protein glycotransferase activity 0.2613769281827526 0.0067888441904856 0.9945833276423792 1.0 1.0 4 P46977 1 +Oligosaccharyl transferase activity 0.2613769281827526 0.0067888441904856 0.9945833276423792 1.0 1.0 4 P46977 1 +Acetyltransferase activity 0.3017835883857805 0.0046043139297716 0.9963263019825704 1.0 1.0 24 Q86UY6,Q9UKN8,Q969G3,P40939,Q96QD8,Q9BWD1,Q9H9T3 7 +Copper ion binding 0.3185094635557454 0.0003799745239384 0.9996968242011466 1.0 1.0 8 O43819,P35670 2 diff --git a/msigdb_gomf/selections.json b/msigdb_gomf/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..3fa14ed6547b42cec828dccad98de7aad55c8883 --- /dev/null +++ b/msigdb_gomf/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["1 4 alpha oligoglucan phosphorylase activity", "1 acylglycerophosphocholine o acyltransferase activity", "1 alkyl 2 acetylglycerophosphocholine esterase activity", "1 phosphatidylinositol 3 kinase activity", "1 phosphatidylinositol 4 phosphate 3 kinase activity", "1 phosphatidylinositol 4 phosphate 5 kinase activity", "1 phosphatidylinositol binding", "17 beta hydroxysteroid dehydrogenase nadplus activity", "17 beta hydroxysteroid dehydrogenase nadpplus activity", "2 acylglycerol 3 phosphate o acyltransferase activity", "2 acylglycerol o acyltransferase activity", "2 iron 2 sulfur cluster binding", "2 oxoglutarate dependent dioxygenase activity", "3 5 dna helicase activity", "3 5 exodeoxyribonuclease activity", "3 5 exonuclease activity", "3 beta hydroxy delta5 steroid dehydrogenase activity", "3 hydroxyacyl coa dehydratase activity", "3 hydroxyacyl coa dehydrogenase activity", "4 iron 4 sulfur cluster binding", "5 3 dna helicase activity", "5 3 exodeoxyribonuclease activity", "5 3 exonuclease activity", "5 deoxyribose 5 phosphate lyase activity", "5s rrna binding", "7s rna binding", "7sk snrna binding", "Abc type transporter activity", "Abc type xenobiotic transporter activity", "Acetyl coa c acetyltransferase activity", "Acetyl coa c acyltransferase activity", "Acetyl coa hydrolase activity", "Acetylcholine receptor binding", "Acetylgalactosaminyltransferase activity", "Acetylglucosaminyltransferase activity", "Acetyltransferase activity", "Acid amino acid ligase activity", "Acid phosphatase activity", "Acid thiol ligase activity", "Acidic amino acid transmembrane transporter activity", "Actin binding", "Actin filament binding", "Actin monomer binding", "Actinin binding", "Active ion transmembrane transporter activity", "Active transmembrane transporter activity", "Activin binding", "Acyl carnitine transmembrane transporter activity", "Acyl coa binding", "Acyl coa dehydrogenase activity", "Acyl coa oxidase activity", "Acylglycerol lipase activity", "Acylglycerol o acyltransferase activity", "Acyltransferase activity", "Acyltransferase acyl groups converted into alkyl on transfer", "Adenosine deaminase activity", "Adenyl nucleotide binding", "Adenyl nucleotide exchange factor activity", "Adenylate cyclase binding", "Adenylate kinase activity", "Adenylyltransferase activity", "Adp binding", "Adp ribose diphosphatase activity", "Adp transmembrane transporter activity", "Adrenergic receptor binding", "Alanine transmembrane transporter activity", "Alcohol binding", "Alcohol dehydrogenase activity zinc dependent", "Alcohol dehydrogenase nad p plus activity", "Alcohol dehydrogenase nadpplus activity", "Aldehyde dehydrogenase nad p plus activity", "Aldehyde lyase activity", "Alditol nadpplus 1 oxidoreductase activity", "Aldo keto reductase nadp activity", "Alkali metal ion binding", "Alpha actinin binding", "Alpha catenin binding", "Alpha glucosidase activity", "Alpha tubulin binding", "Amide binding", "Amide transmembrane transporter activity", "Amidine lyase activity", "Amino acid binding", "Amino acid cation symporter activity", "Amino acid sodium symporter activity", "Amino acid transmembrane transporter activity", "Aminoacyl trna editing activity", "Aminoacylase activity", "Aminopeptidase activity", "Ammonium transmembrane transporter activity", "Amp binding", "Amyloid beta binding", "Anaphase promoting complex binding", "Androgen receptor binding", "Androstan 3 alpha 17 beta diol dehydrogenase activity", "Anion cation symporter activity", "Anion channel activity", "Anion sodium symporter activity", "Anion transmembrane transporter activity", "Ankyrin binding", "Ankyrin repeat binding", "Annealing activity", "Antigen binding", "Antioxidant activity", "Antiporter activity", "Apolipoprotein a i binding", "Apolipoprotein binding", "Apolipoprotein receptor binding", "Arachidonate coa ligase activity", "Arginine binding", "Armadillo repeat domain binding", "Aromatic amino acid transmembrane transporter activity", "Arp2 3 complex binding", "Aryl hydrocarbon receptor binding", "Arylesterase activity", "Arylsulfatase activity", "Aspartic endopeptidase activity intramembrane cleaving", "Aspartic type endopeptidase inhibitor activity", "Aspartic type peptidase activity", "Atp dependent activity", "Atp dependent activity acting on dna", "Atp dependent activity acting on rna", "Atp dependent chromatin remodeler activity", "Atp dependent dna dna annealing activity", "Atp dependent peptidase activity", "Atp dependent protein binding", "Atp hydrolysis activity", "Atp transmembrane transporter activity", "Atpase activator activity", "Atpase binding", "Atpase coupled cation transmembrane transporter activity", "Atpase coupled inorganic anion transmembrane transporter activity", "Atpase coupled intramembrane lipid transporter activity", "Atpase coupled ion transmembrane transporter activity", "Atpase coupled transmembrane transporter activity", "Atpase inhibitor activity", "Atpase regulator activity", "Axon guidance receptor activity", "Azole transmembrane transporter activity", "Basal transcription machinery binding", "Benzodiazepine receptor activity", "Beta 1 3 galactosyltransferase activity", "Beta 2 adrenergic receptor binding", "Beta 2 microglobulin binding", "Beta catenin binding", "Beta galactosidase activity", "Beta n acetylhexosaminidase activity", "Beta tubulin binding", "Bh domain binding", "Bh3 domain binding", "Bhlh transcription factor binding", "Bicarbonate transmembrane transporter activity", "Bile acid binding", "Biotin binding", "Box h aca snorna binding", "Branched chain amino acid transmembrane transporter activity", "Bubble dna binding", "C acetyltransferase activity", "C acyltransferase activity", "C methyltransferase activity", "C palmitoyltransferase activity", "C x c chemokine binding", "C x3 c chemokine binding", "C2h2 zinc finger domain binding", "C3hc4 type ring finger domain binding", "C4 dicarboxylate transmembrane transporter activity", "Cadherin binding", "Cadherin binding involved in cell cell adhesion", "Calcium activated cation channel activity", "Calcium cation antiporter activity", "Calcium channel inhibitor activity", "Calcium channel regulator activity", "Calcium dependent cysteine type endopeptidase activity", "Calcium dependent phospholipid binding", "Calcium dependent protein binding", "Calcium dependent protein kinase activity", "Calcium dependent protein serine threonine phosphatase activity", "Calcium independent phospholipase a2 activity", "Calcium ion binding", "Calcium ion transmembrane transporter activity", "Calmodulin binding", "Calmodulin dependent protein kinase activity", "Camp binding", "Camp dependent protein kinase activity", "Camp dependent protein kinase inhibitor activity", "Camp dependent protein kinase regulator activity", "Carbohydrate binding", "Carbohydrate derivative transmembrane transporter activity", "Carbohydrate kinase activity", "Carbohydrate phosphatase activity", "Carbon carbon lyase activity", "Carbon nitrogen ligase activity with glutamine as amido n donor", "Carbon nitrogen lyase activity", "Carbon oxygen lyase activity", "Carbon sulfur lyase activity", "Carbonyl reductase nadph activity", "Carboxy lyase activity", "Carboxylic acid binding", "Carboxylic ester hydrolase activity", "Carboxypeptidase activity", "Card domain binding", "Cardiolipin binding", "Cargo adaptor activity", "Cargo receptor activity", "Carnitine o acyltransferase activity", "Catalytic activity acting on a glycoprotein", "Catalytic activity acting on a nucleic acid", "Catalytic activity acting on a rrna", "Catalytic activity acting on a trna", "Catalytic activity acting on dna", "Catalytic activity acting on rna", "Cation cation antiporter activity", "Cation channel activity", "Cation chloride symporter activity", "Cation transmembrane transporter activity", "Ccr chemokine receptor binding", "Ccr3 chemokine receptor binding", "Ccr5 chemokine receptor binding", "Cdp alcohol phosphatidyltransferase activity", "Cell adhesion mediator activity", "Cell adhesion molecule binding", "Cell adhesive protein binding involved in bundle of his cell purkinje myocyte communication", "Cell cell adhesion mediator activity", "Cell matrix adhesion mediator activity", "Centromeric dna binding", "Ceramide 1 phosphate binding", "Ceramide 1 phosphate transfer activity", "Ceramide binding", "Cgmp binding", "Channel inhibitor activity", "Channel regulator activity", "Chaperone binding", "Chemoattractant activity", "Chemokine binding", "Chemokine receptor binding", "Chemorepellent activity", "Chitin binding", "Chitinase activity", "Chloride channel inhibitor activity", "Chloride channel regulator activity", "Chloride ion binding", "Chloride transmembrane transporter activity", "Cholesterol binding", "Chondroitin sulfate binding", "Chromatin binding", "Chromatin dna binding", "Chromo shadow domain binding", "Cis regulatory region sequence specific dna binding", "Cis trans isomerase activity", "Class i dna apurinic or apyrimidinic site endonuclease activity", "Clathrin binding", "Clathrin heavy chain binding", "Clathrin light chain binding", "Co smad binding", "Coa hydrolase activity", "Cobalamin binding", "Collagen binding", "Collagen binding involved in cell matrix adhesion", "Complement binding", "Complement component c1q complex binding", "Complement component c3b binding", "Connexin binding", "Copper chaperone activity", "Copper ion binding", "Copper ion transmembrane transporter activity", "Core promoter sequence specific dna binding", "Coreceptor activity", "Coreceptor activity involved in wnt signaling pathway", "Coreceptor activity involved in wnt signaling pathway planar cell polarity pathway", "Cullin family protein binding", "Cuprous ion binding", "Cxcr chemokine receptor binding", "Cyclase regulator activity", "Cyclic nucleotide binding", "Cyclic nucleotide dependent protein kinase activity", "Cyclic nucleotide phosphodiesterase activity", "Cyclin binding", "Cyclin dependent protein kinase activity", "Cyclin dependent protein serine threonine kinase activator activity", "Cyclin dependent protein serine threonine kinase regulator activity", "Cyclohydrolase activity", "Cyclosporin a binding", "Cysteine type endopeptidase activity", "Cysteine type endopeptidase inhibitor activity", "Cysteine type endopeptidase inhibitor activity involved in apoptotic process", "Cysteine type endopeptidase regulator activity involved in apoptotic process", "Cysteine type exopeptidase activity", "Cysteine type peptidase activity", "Cytidylyltransferase activity", "Cytochrome b5 reductase activity acting on nad p h", "Cytokine activity", "Cytokine binding", "Cytokine receptor binding", "Cytoskeletal anchor activity", "Cytoskeletal motor activity", "Cytoskeletal protein binding", "Cytoskeleton nuclear membrane anchor activity", "D threo aldose 1 dehydrogenase activity", "D1 dopamine receptor binding", "Damaged dna binding", "Deacetylase activity", "Dead h box rna helicase binding", "Deaminase activity", "Death domain binding", "Death receptor activity", "Demethylase activity", "Deoxynucleoside kinase activity", "Deoxyribonuclease activity", "Diacylglycerol binding", "Diacylglycerol kinase activity", "Dicarboxylic acid transmembrane transporter activity", "Dihydropyrimidinase activity", "Dioxygenase activity", "Dipeptidase activity", "Dipeptidyl peptidase activity", "Diphosphotransferase activity", "Disordered domain specific binding", "Disulfide oxidoreductase activity", "Dna apurinic or apyrimidinic site endonuclease activity", "Dna binding bending", "Dna binding transcription activator activity", "Dna binding transcription factor activity", "Dna binding transcription factor binding", "Dna binding transcription repressor activity", "Dna clamp loader activity", "Dna directed dna polymerase activity", "Dna dna annealing activity", "Dna helicase activity", "Dna insertion or deletion binding", "Dna methyltransferase activity", "Dna n glycosylase activity", "Dna polymerase activity", "Dna polymerase binding", "Dna replication origin binding", "Dna secondary structure binding", "Dna topoisomerase activity", "Dolichyl diphosphooligosaccharide protein glycotransferase activity", "Dolichyl phosphate mannose protein mannosyltransferase activity", "Dopamine receptor binding", "Double stranded methylated dna binding", "Double stranded rna adenosine deaminase activity", "Double stranded rna binding", "Double stranded telomeric dna binding", "Dttp diphosphatase activity", "Dynactin binding", "Dynein complex binding", "Dynein heavy chain binding", "Dynein intermediate chain binding", "Dynein light intermediate chain binding", "Dystroglycan binding", "E box binding", "Efflux transmembrane transporter activity", "Electron transfer activity", "Endodeoxyribonuclease activity", "Endodeoxyribonuclease activity producing 3 phosphomonoesters", "Endodeoxyribonuclease activity producing 5 phosphomonoesters", "Endonuclease activity", "Endonuclease activity active with either ribo or deoxyribonucleic acids and producing 3 phosphomonoesters", "Endonuclease activity active with either ribo or deoxyribonucleic acids and producing 5 phosphomonoesters", "Endopeptidase activator activity", "Endopeptidase activity", "Endopeptidase regulator activity", "Endoribonuclease activity", "Endoribonuclease activity producing 3 phosphomonoesters", "Endoribonuclease activity producing 5 phosphomonoesters", "Enoyl coa hydratase activity", "Enzyme activator activity", "Enzyme inhibitor activity", "Enzyme regulator activity", "Ephrin receptor activity", "Ephrin receptor binding", "Epidermal growth factor receptor binding", "Epoxide hydrolase activity", "Er retention sequence binding", "Erbb 3 class receptor binding", "Estradiol 17 beta dehydrogenase activity", "Estrogen receptor binding", "Ether hydrolase activity", "Eukaryotic initiation factor 4e binding", "Exodeoxyribonuclease activity", "Exogenous protein binding", "Exonuclease activity", "Exonuclease activity active with either ribo or deoxyribonucleic acids and producing 5 phosphomonoesters", "Exopeptidase activity", "Exoribonuclease activity", "Exoribonuclease activity producing 5 phosphomonoesters", "Extracellular matrix binding", "Fad binding", "Fatty acid binding", "Fatty acid derivative binding", "Fatty acid ligase activity", "Fatty acid synthase activity", "Fatty acid transmembrane transporter activity", "Fatz binding", "Ferric iron binding", "Ferrous iron binding", "Fibroblast growth factor binding", "Fibronectin binding", "Fk506 binding", "Flap endonuclease activity", "Flavin adenine dinucleotide binding", "Flippase activity", "Floppase activity", "Fmn binding", "Folic acid binding", "Folic acid transmembrane transporter activity", "Four way junction dna binding", "Four way junction helicase activity", "Frizzled binding", "Fructose 2 6 bisphosphate 2 phosphatase activity", "Fructose 6 phosphate binding", "Fructose binding", "G protein activity", "G protein alpha subunit binding", "G protein beta gamma subunit complex binding", "G protein beta subunit binding", "G protein coupled glutamate receptor binding", "G protein coupled opioid receptor activity", "G protein coupled receptor activity", "G protein coupled receptor binding", "G protein coupled serotonin receptor binding", "G quadruplex dna binding", "G quadruplex rna binding", "G rich strand telomeric dna binding", "Gaba receptor binding", "Galactosidase activity", "Galactoside binding", "Galactosyltransferase activity", "Gamma aminobutyric acid transmembrane transporter activity", "Gamma catenin binding", "Gamma tubulin binding", "Ganglioside binding", "Gated channel activity", "Gdp binding", "Gdp dissociation inhibitor activity", "General transcription initiation factor activity", "General transcription initiation factor binding", "Glucocorticoid receptor binding", "Glucose binding", "Glucosidase activity", "Glucosyltransferase activity", "Glucuronosyl n acetylgalactosaminyl proteoglycan 4 beta n acetylgalactosaminyltransferase activity", "Glucuronosyltransferase activity", "Glutamate binding", "Glutamate receptor binding", "Glutathione disulfide oxidoreductase activity", "Glutathione oxidoreductase activity", "Glutathione peroxidase activity", "Glutathione transferase activity", "Glyceraldehyde 3 phosphate dehydrogenase nadplus non phosphorylating activity", "Glycerophospholipid flippase activity", "Glycine binding", "Glycolipid binding", "Glycolipid mannosyltransferase activity", "Glycosaminoglycan binding", "Glycosphingolipid binding", "Glycosyltransferase activity", "Gpi linked ephrin receptor activity", "Growth factor activity", "Growth factor binding", "Growth factor receptor binding", "Gtp dependent protein binding", "Gtpase activating protein binding", "Gtpase activator activity", "Gtpase activity", "Gtpase binding", "Gtpase inhibitor activity", "Guanyl nucleotide binding", "Guanyl nucleotide exchange factor activity", "Guanylate kinase activity", "Guanylyltransferase activity", "H4 histone acetyltransferase activity", "Heat shock protein binding", "Helicase activity", "Heme transmembrane transporter activity", "Heparin binding", "Hexokinase activity", "Hexosaminidase activity", "Hexosyltransferase activity", "High density lipoprotein particle binding", "Histone acetyltransferase binding", "Histone arginine n methyltransferase activity", "Histone binding", "Histone deacetylase activity h3 k14 specific", "Histone deacetylase binding", "Histone deacetylase regulator activity", "Histone h3 di monomethyl lysine 9 demethylase activity", "Histone h3 methyl lysine 36 demethylase activity", "Histone h3 methyl lysine 4 demethylase activity", "Histone h3 methyl lysine 9 demethylase activity", "Histone h3 tri di methyl lysine 27 demethylase activity", "Histone h3 tri di monomethyl lysine 4 demethylase activity", "Histone kinase activity", "Histone lysine n methyltransferase activity", "Histone methyltransferase activity", "Histone methyltransferase activity h3 k36 specific", "Histone methyltransferase activity h3 k4 specific", "Histone methyltransferase activity h4 k20 specific", "Histone methyltransferase binding", "Histone serine kinase activity", "Histone threonine kinase activity", "Hormone activity", "Hormone binding", "Hormone receptor binding", "Hsp70 protein binding", "Hsp90 protein binding", "Hyaluronic acid binding", "Hyalurononglucosaminidase activity", "Hydro lyase activity", "Hydrolase activity acting on acid anhydrides", "Hydrolase activity acting on carbon nitrogen but not peptide bonds", "Hydrolase activity acting on carbon nitrogen but not peptide bonds in cyclic amides", "Hydrolase activity acting on carbon nitrogen but not peptide bonds in cyclic amidines", "Hydrolase activity acting on carbon nitrogen but not peptide bonds in linear amides", "Hydrolase activity acting on ester bonds", "Hydrolase activity acting on ether bonds", "Hydrolase activity acting on glycosyl bonds", "Hydrolase activity hydrolyzing n glycosyl compounds", "Hydrolase activity hydrolyzing o glycosyl compounds", "Hydroxymethyl formyl and related transferase activity", "I smad binding", "Identical protein binding", "Ige binding", "Igg binding", "Immunoglobulin binding", "Immunoglobulin receptor binding", "Importin alpha family protein binding", "Inorganic anion exchanger activity", "Inorganic anion transmembrane transporter activity", "Inorganic diphosphatase activity", "Inorganic molecular entity transmembrane transporter activity", "Inorganic phosphate transmembrane transporter activity", "Inositol 1 4 5 trisphosphate 5 phosphatase activity", "Inositol phosphate phosphatase activity", "Inositol polyphosphate 5 phosphatase activity", "Inositol tetrakisphosphate phosphatase activity", "Inositol trisphosphate phosphatase activity", "Insulin binding", "Insulin like growth factor binding", "Insulin like growth factor ii binding", "Insulin like growth factor receptor binding", "Insulin receptor binding", "Insulin receptor substrate binding", "Integrin binding", "Interleukin 1 receptor binding", "Interleukin 2 receptor binding", "Interleukin 6 receptor binding", "Intermediate filament binding", "Intracellular calcium activated chloride channel activity", "Intraciliary transport particle b binding", "Intramembrane lipid transporter activity", "Intramolecular oxidoreductase activity", "Intramolecular oxidoreductase activity interconverting aldoses and ketoses", "Intramolecular oxidoreductase activity transposing c c bonds", "Intramolecular transferase activity", "Intramolecular transferase activity phosphotransferases", "Intronic transcription regulatory region sequence specific dna binding", "Ion gated channel activity", "Ion transmembrane transporter activity", "Ionotropic glutamate receptor binding", "Iron ion binding", "Iron ion transmembrane transporter activity", "Isocitrate dehydrogenase activity", "Isomerase activity", "Isopeptidase activity", "Isoprenoid binding", "Jun kinase binding", "K48 linked polyubiquitin modification dependent protein binding", "K63 linked polyubiquitin modification dependent protein binding", "Keratin filament binding", "Kinase activator activity", "Kinase activity", "Kinase binding", "Kinase inhibitor activity", "Kinase regulator activity", "Kinesin binding", "Kinetochore binding", "L alanine transmembrane transporter activity", "L amino acid transmembrane transporter activity", "L ascorbic acid binding", "L aspartate transmembrane transporter activity", "L glutamine transmembrane transporter activity", "L lactate dehydrogenase activity", "L leucine transmembrane transporter activity", "L ornithine transmembrane transporter activity", "L serine transmembrane transporter activity", "Lactate dehydrogenase activity", "Lactate transmembrane transporter activity", "Lamin binding", "Laminin 1 binding", "Laminin binding", "Large ribosomal subunit rrna binding", "Lbd domain binding", "Leucine binding", "Leucine zipper domain binding", "Leukotriene c4 synthase activity", "Ligand gated ion channel activity", "Ligase activity", "Ligase activity forming carbon carbon bonds", "Ligase activity forming carbon nitrogen bonds", "Ligase activity forming carbon oxygen bonds", "Ligase activity forming carbon sulfur bonds", "Ligase activity forming phosphoric ester bonds", "Lim domain binding", "Lipase activator activity", "Lipase activity", "Lipase binding", "Lipase inhibitor activity", "Lipid binding", "Lipid kinase activity", "Lipid phosphatase activity", "Lipid transfer activity", "Lipid transporter activity", "Lipopolysaccharide binding", "Lipopolysaccharide immune receptor activity", "Lipoprotein particle receptor activity", "Lipoprotein particle receptor binding", "Long chain acyl coa dehydrogenase activity", "Long chain fatty acid binding", "Long chain fatty acid coa ligase activity", "Long chain fatty acid transporter activity", "Long chain fatty acyl coa binding", "Low density lipoprotein particle binding", "Low density lipoprotein particle receptor binding", "Lrr domain binding", "Lyase activity", "Lys48 specific deubiquitinase activity", "Lys63 specific deubiquitinase activity", "Lysine acetylated histone binding", "Lysine n methyltransferase activity", "Lysophosphatidic acid binding", "Lysophosphatidic acid phosphatase activity", "Lysophospholipase activity", "Lysophospholipid acyltransferase activity", "M7g 5 pppn diphosphatase activity", "Macrolide binding", "Macromolecule transmembrane transporter activity", "Magnesium ion binding", "Magnesium ion transmembrane transporter activity", "Malate dehydrogenase activity", "Manganese ion binding", "Manganese ion transmembrane transporter activity", "Mannose binding", "Mannosidase activity", "Mannosyl oligosaccharide mannosidase activity", "Mannosyltransferase activity", "Map kinase activity", "Map kinase kinase activity", "Map kinase phosphatase activity", "Map kinase scaffold activity", "Map kinase tyrosine serine threonine phosphatase activity", "Mdm2 mdm4 family protein binding", "Medium chain fatty acid coa ligase activity", "Membrane insertase activity", "Metal cluster binding", "Metal dependent deubiquitinase activity", "Metal ion proton antiporter activity", "Metal ion transmembrane transporter activity", "Metalloaminopeptidase activity", "Metallocarboxypeptidase activity", "Metallochaperone activity", "Metallodipeptidase activity", "Metalloendopeptidase activity", "Metalloexopeptidase activity", "Metallopeptidase activity", "Methyl cpg binding", "Methylated histone binding", "Mhc class i protein binding", "Mhc class ib protein binding", "Mhc class ii protein complex binding", "Mhc protein binding", "Mhc protein complex binding", "Microfilament motor activity", "Microtubule binding", "Microtubule minus end binding", "Microtubule motor activity", "Microtubule plus end binding", "Minor groove of adenine thymine rich dna binding", "Minus end directed microtubule motor activity", "Mirna binding", "Misfolded protein binding", "Mismatch repair complex binding", "Mismatched dna binding", "Mitochondrial ribosome binding", "Mitochondrion targeting sequence binding", "Mitogen activated protein kinase binding", "Mitogen activated protein kinase kinase binding", "Mitogen activated protein kinase kinase kinase binding", "Mitogen activated protein kinase p38 binding", "Modification dependent protein binding", "Modified amino acid binding", "Modified amino acid transmembrane transporter activity", "Molecular adaptor activity", "Molecular carrier activity", "Molecular function activator activity", "Molecular function inhibitor activity", "Molecular function regulator", "Molecular transducer activity", "Molybdopterin cofactor binding", "Monocarboxylic acid binding", "Monocarboxylic acid transmembrane transporter activity", "Monooxygenase activity", "Monosaccharide binding", "Mrf binding", "Mrna 3 utr au rich region binding", "Mrna 3 utr binding", "Mrna 5 utr binding", "Mrna binding", "Mrna methyltransferase activity", "Muscle alpha actinin binding", "Mutlalpha complex binding", "Myosin binding", "Myosin heavy chain binding", "Myosin ii binding", "Myosin v binding", "Myristoyltransferase activity", "N acetylgalactosamine 4 o sulfotransferase activity", "N acetyllactosaminide beta 1 3 n acetylglucosaminyltransferase activity", "N acetyltransferase activity", "N acylsphingosine amidohydrolase activity", "N acyltransferase activity", "N methyltransferase activity", "N6 methyladenosine containing rna binding", "Nad binding", "Nad dependent protein deacetylase activity", "Nad p h oxidase h2o2 forming activity", "Nad p plus protein arginine adp ribosyltransferase activity", "Nad retinol dehydrogenase activity", "Nadh dehydrogenase activity", "Nadh pyrophosphatase activity", "Nadp binding", "Nadp retinol dehydrogenase activity", "Nadph binding", "Nadplus adp ribosyltransferase activity", "Nadplus binding", "Nadplus kinase activity", "Nedd8 specific protease activity", "Nedd8 transferase activity", "Nerve growth factor binding", "Neurexin family protein binding", "Neuroligin family protein binding", "Neurotransmitter receptor activity", "Neurotransmitter receptor regulator activity", "Neurotransmitter transmembrane transporter activity", "Neurotrophin binding", "Neurotrophin receptor activity", "Neurotrophin receptor binding", "Neurotrophin trk receptor binding", "Neutral amino acid transmembrane transporter activity", "Nf kappab binding", "Nf kappab inducing kinase activity", "Nitric oxide synthase binding", "Nitric oxide synthase regulator activity", "Nitrite reductase activity", "Non membrane spanning protein tyrosine kinase activity", "Non membrane spanning protein tyrosine phosphatase activity", "Notch binding", "Nuclear export signal receptor activity", "Nuclear import signal receptor activity", "Nuclear localization sequence binding", "Nuclear receptor activity", "Nuclear receptor binding", "Nuclear receptor coactivator activity", "Nuclease activity", "Nucleobase containing compound kinase activity", "Nucleobase containing compound transmembrane transporter activity", "Nucleobase transmembrane transporter activity", "Nucleocytoplasmic carrier activity", "Nucleoside binding", "Nucleoside diphosphatase activity", "Nucleoside diphosphate kinase activity", "Nucleoside kinase activity", "Nucleoside monophosphate kinase activity", "Nucleoside transmembrane transporter activity", "Nucleoside triphosphatase regulator activity", "Nucleoside triphosphate diphosphatase activity", "Nucleosomal dna binding", "Nucleosome binding", "Nucleotidase activity", "Nucleotide diphosphatase activity", "Nucleotide phosphatase activity acting on free nucleotides", "Nucleotide sugar transmembrane transporter activity", "Nucleotide transmembrane transporter activity", "Nucleotidyltransferase activity", "O acetyltransferase activity", "O acyltransferase activity", "O methyltransferase activity", "O palmitoyltransferase activity", "Oleate transmembrane transporter activity", "Oligopeptide binding", "Oligosaccharide binding", "Oligosaccharyl transferase activity", "Omega peptidase activity", "Opsonin binding", "Organic acid binding", "Organic acid sodium symporter activity", "Organic acid transmembrane transporter activity", "Organic anion transmembrane transporter activity", "Organic cation transmembrane transporter activity", "Organic hydroxy compound transmembrane transporter activity", "Organophosphate ester transmembrane transporter activity", "Oxidative phosphorylation uncoupler activity", "Oxidative rna demethylase activity", "Oxidized dna binding", "Oxidoreductase activity", "Oxidoreductase activity acting on a heme group of donors", "Oxidoreductase activity acting on a sulfur group of donors", "Oxidoreductase activity acting on a sulfur group of donors disulfide as acceptor", "Oxidoreductase activity acting on a sulfur group of donors nad p as acceptor", "Oxidoreductase activity acting on a sulfur group of donors oxygen as acceptor", "Oxidoreductase activity acting on ch oh group of donors", "Oxidoreductase activity acting on ch or ch2 groups", "Oxidoreductase activity acting on diphenols and related substances as donors", "Oxidoreductase activity acting on nad p h", "Oxidoreductase activity acting on nad p h heme protein as acceptor", "Oxidoreductase activity acting on nad p h oxygen as acceptor", "Oxidoreductase activity acting on nad p h quinone or similar compound as acceptor", "Oxidoreductase activity acting on other nitrogenous compounds as donors", "Oxidoreductase activity acting on other nitrogenous compounds as donors cytochrome as acceptor", "Oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen", "Oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen nad p h as one donor and incorporation of one atom of oxygen", "Oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen reduced flavin or flavoprotein as one donor and incorporation of one atom of oxygen", "Oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen reduced pteridine as one donor and incorporation of one atom of oxygen", "Oxidoreductase activity acting on paired donors with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water", "Oxidoreductase activity acting on peroxide as acceptor", "Oxidoreductase activity acting on single donors with incorporation of molecular oxygen", "Oxidoreductase activity acting on the aldehyde or oxo group of donors", "Oxidoreductase activity acting on the aldehyde or oxo group of donors disulfide as acceptor", "Oxidoreductase activity acting on the aldehyde or oxo group of donors nad or nadp as acceptor", "Oxidoreductase activity acting on the ch ch group of donors", "Oxidoreductase activity acting on the ch ch group of donors nad or nadp as acceptor", "Oxidoreductase activity acting on the ch ch group of donors oxygen as acceptor", "Oxidoreductase activity acting on the ch nh group of donors", "Oxidoreductase activity acting on the ch nh group of donors nad or nadp as acceptor", "Oxidoreductase activity acting on the ch nh2 group of donors", "Oxidoreduction driven active transmembrane transporter activity", "Oxygen binding", "Oxygen sensor activity", "Oxysterol binding", "P type calcium transporter activity", "P type potassium transmembrane transporter activity", "P type transmembrane transporter activity", "P53 binding", "Palmitoyl coa hydrolase activity", "Palmitoyl protein hydrolase activity", "Palmitoyltransferase activity", "Passive transmembrane transporter activity", "Patched binding", "Pattern recognition receptor activity", "Pdz domain binding", "Pentosyltransferase activity", "Peptidase activator activity", "Peptidase activator activity involved in apoptotic process", "Peptidase activity", "Peptidase regulator activity", "Peptide alpha n acetyltransferase activity", "Peptide antigen binding", "Peptide binding", "Peptide hormone binding", "Peptide hormone receptor binding", "Peptide lysine n acetyltransferase activity", "Peptide n acetyltransferase activity", "Peptide receptor activity", "Peptidoglycan binding", "Peptidyl proline 4 dioxygenase activity", "Peptidyl proline dioxygenase activity", "Peroxiredoxin activity", "Peroxisome proliferator activated receptor binding", "Peroxisome targeting sequence binding", "Phosphatase activator activity", "Phosphatase activity", "Phosphatase binding", "Phosphatase inhibitor activity", "Phosphatase regulator activity", "Phosphate ion binding", "Phosphatidic acid binding", "Phosphatidyl phospholipase b activity", "Phosphatidylcholine binding", "Phosphatidylcholine floppase activity", "Phosphatidylcholine transfer activity", "Phosphatidylcholine transporter activity", "Phosphatidylethanolamine binding", "Phosphatidylethanolamine flippase activity", "Phosphatidylglycerol binding", "Phosphatidylinositol 3 4 5 trisphosphate 3 phosphatase activity", "Phosphatidylinositol 3 4 5 trisphosphate 5 phosphatase activity", "Phosphatidylinositol 3 4 5 trisphosphate binding", "Phosphatidylinositol 3 5 bisphosphate 3 phosphatase activity", "Phosphatidylinositol 3 5 bisphosphate 5 phosphatase activity", "Phosphatidylinositol 3 5 bisphosphate binding", "Phosphatidylinositol 3 5 bisphosphate phosphatase activity", "Phosphatidylinositol 3 kinase activity", "Phosphatidylinositol 3 kinase binding", "Phosphatidylinositol 3 kinase regulator activity", "Phosphatidylinositol 3 kinase regulatory subunit binding", "Phosphatidylinositol 3 phosphate binding", "Phosphatidylinositol 4 5 bisphosphate 3 kinase activity", "Phosphatidylinositol 4 5 bisphosphate 5 phosphatase activity", "Phosphatidylinositol 4 5 bisphosphate binding", "Phosphatidylinositol 4 5 bisphosphate phosphatase activity", "Phosphatidylinositol 4 phosphate binding", "Phosphatidylinositol 5 phosphate binding", "Phosphatidylinositol binding", "Phosphatidylinositol bisphosphate binding", "Phosphatidylinositol bisphosphate kinase activity", "Phosphatidylinositol bisphosphate phosphatase activity", "Phosphatidylinositol kinase activity", "Phosphatidylinositol monophosphate phosphatase activity", "Phosphatidylinositol phosphate 4 phosphatase activity", "Phosphatidylinositol phosphate 5 phosphatase activity", "Phosphatidylinositol phosphate binding", "Phosphatidylinositol phosphate kinase activity", "Phosphatidylinositol phosphate phosphatase activity", "Phosphatidylinositol transfer activity", "Phosphatidylinositol trisphosphate phosphatase activity", "Phosphatidylserine 1 acylhydrolase activity", "Phosphatidylserine binding", "Phosphodiesterase i activity", "Phosphofructokinase activity", "Phospholipase a1 activity", "Phospholipase a2 activity", "Phospholipase a2 inhibitor activity", "Phospholipase activity", "Phospholipase binding", "Phospholipase c activity", "Phospholipase d activity", "Phospholipase inhibitor activity", "Phospholipid binding", "Phospholipid scramblase activity", "Phospholipid transfer activity", "Phospholipid transporter activity", "Phosphoprotein binding", "Phosphoprotein phosphatase activity", "Phosphoric diester hydrolase activity", "Phosphoric ester hydrolase activity", "Phosphorus oxygen lyase activity", "Phosphoserine residue binding", "Phosphotransferase activity for other substituted phosphate groups", "Phosphotransferase activity nitrogenous group as acceptor", "Phosphotransferase activity phosphate group as acceptor", "Phosphotyrosine residue binding", "Plus end directed microtubule motor activity", "Poly a binding", "Poly a specific ribonuclease activity", "Poly g binding", "Poly purine tract binding", "Poly pyrimidine tract binding", "Polynucleotide adenylyltransferase activity", "Polypeptide n acetylgalactosaminyltransferase activity", "Polysaccharide binding", "Polysome binding", "Polyubiquitin modification dependent protein binding", "Porin activity", "Potassium channel inhibitor activity", "Potassium channel regulator activity", "Potassium chloride symporter activity", "Potassium ion binding", "Potassium ion transmembrane transporter activity", "Pre mirna binding", "Pre mrna 3 splice site binding", "Pre mrna 5 splice site binding", "Pre mrna binding", "Pre mrna intronic binding", "Prenyltransferase activity", "Primary active transmembrane transporter activity", "Primary mirna binding", "Procollagen proline 4 dioxygenase activity", "Procollagen proline dioxygenase activity", "Profilin binding", "Proline rich region binding", "Promoter specific chromatin binding", "Protease binding", "Proteasome activating activity", "Proteasome binding", "Protein adp ribosylase activity", "Protein antigen binding", "Protein arginine n methyltransferase activity", "Protein arginine omega n asymmetric methyltransferase activity", "Protein arginine omega n monomethyltransferase activity", "Protein binding involved in heterotypic cell cell adhesion", "Protein c terminus binding", "Protein carboxyl o methyltransferase activity", "Protein carrier chaperone", "Protein containing complex binding", "Protein deacetylase activity", "Protein demethylase activity", "Protein dimerization activity", "Protein disaggregase activity", "Protein disulfide isomerase activity", "Protein disulfide reductase nad p activity", "Protein domain specific binding", "Protein folding chaperone", "Protein geranylgeranyltransferase activity", "Protein heterodimerization activity", "Protein homodimerization activity", "Protein kinase a binding", "Protein kinase a catalytic subunit binding", "Protein kinase a regulatory subunit binding", "Protein kinase activity", "Protein kinase b binding", "Protein kinase c activity", "Protein kinase c binding", "Protein lipid complex binding", "Protein macromolecule adaptor activity", "Protein membrane adaptor activity", "Protein methyltransferase activity", "Protein n terminus binding", "Protein phosphatase 1 binding", "Protein phosphatase 2a binding", "Protein phosphatase activator activity", "Protein phosphatase binding", "Protein phosphatase regulator activity", "Protein phosphorylated amino acid binding", "Protein prenyltransferase activity", "Protein self association", "Protein serine kinase activity", "Protein serine threonine kinase activator activity", "Protein serine threonine kinase activity", "Protein serine threonine kinase inhibitor activity", "Protein serine threonine phosphatase activity", "Protein serine threonine tyrosine kinase activity", "Protein transmembrane transporter activity", "Protein transporter activity", "Protein tyrosine kinase activator activity", "Protein tyrosine kinase activity", "Protein tyrosine kinase binding", "Protein tyrosine kinase inhibitor activity", "Protein tyrosine phosphatase activity", "Protein tyrosine serine threonine phosphatase activity", "Protein tyrosine threonine phosphatase activity", "Proteoglycan binding", "Proton channel activity", "Proton transmembrane transporter activity", "Proton transporting atp synthase activity rotational mechanism", "Pseudouridine synthase activity", "Purine nucleotide transmembrane transporter activity", "Pyrimidine nucleoside transmembrane transporter activity", "Pyrimidine nucleotide binding", "Pyrimidine nucleotide sugar transmembrane transporter activity", "Pyrophosphate hydrolysis driven proton transmembrane transporter activity", "Pyruvate dehydrogenase acetyl transferring kinase activity", "Pyruvate dehydrogenase activity", "Pyruvate transmembrane transporter activity", "Quaternary ammonium group binding", "Quaternary ammonium group transmembrane transporter activity", "Quinone binding", "R smad binding", "Racemase and epimerase activity", "Racemase and epimerase activity acting on carbohydrates and derivatives", "Rage receptor binding", "Rdna binding", "Receptor tyrosine kinase binding", "Regulatory rna binding", "Retinal dehydrogenase activity", "Retinoic acid binding", "Retinoic acid receptor binding", "Retinoid x receptor binding", "Retromer complex binding", "Ribonuclease activity", "Ribonuclease p activity", "Ribonuclease p rna binding", "Ribonucleoprotein complex binding", "Ribonucleotide binding", "Ribose phosphate diphosphokinase activity", "Ribosomal large subunit binding", "Ribosomal protein s6 kinase activity", "Ribosomal small subunit binding", "Ribosome binding", "Rna 2 o methyltransferase activity", "Rna 7 methylguanosine cap binding", "Rna adenylyltransferase activity", "Rna binding", "Rna binding involved in posttranscriptional gene silencing", "Rna cap binding", "Rna directed dna polymerase activity", "Rna dna hybrid ribonuclease activity", "Rna methyltransferase activity", "Rna polymerase activity", "Rna polymerase binding", "Rna polymerase core enzyme binding", "Rna polymerase i general transcription initiation factor activity", "Rna polymerase i transcription regulatory region sequence specific dna binding", "Rna polymerase ii activity", "Rna polymerase ii c terminal domain binding", "Rna polymerase ii core promoter sequence specific dna binding", "Rna polymerase ii ctd heptapeptide repeat kinase activity", "Rna polymerase ii general transcription initiation factor activity", "Rna polymerase ii general transcription initiation factor binding", "Rna polymerase ii intronic transcription regulatory region sequence specific dna binding", "Rna polymerase ii specific dna binding transcription factor binding", "Rna polymerase iii transcription regulatory region sequence specific dna binding", "Rna stem loop binding", "Rna strand annealing activity", "Roundabout binding", "Rrna adenine methyltransferase activity", "Rrna binding", "Rrna cytosine methyltransferase activity", "S acyltransferase activity", "S adenosyl l methionine binding", "S adenosylmethionine dependent methyltransferase activity", "S methyltransferase activity", "S100 protein binding", "Scaffold protein binding", "Scavenger receptor activity", "Secondary active transmembrane transporter activity", "Semaphorin receptor activity", "Sequence specific dna binding", "Sequence specific mrna binding", "Sequence specific single stranded dna binding", "Serine hydrolase activity", "Serine transmembrane transporter activity", "Serine type carboxypeptidase activity", "Serine type endopeptidase inhibitor activity", "Serine type exopeptidase activity", "Sh2 domain binding", "Sh3 domain binding", "Signal recognition particle binding", "Signal sequence binding", "Signaling adaptor activity", "Signaling receptor binding", "Signaling receptor complex adaptor activity", "Signaling receptor regulator activity", "Single stranded dna 3 5 exodeoxyribonuclease activity", "Single stranded dna binding", "Single stranded dna endodeoxyribonuclease activity", "Single stranded dna exodeoxyribonuclease activity", "Single stranded dna helicase activity", "Single stranded rna binding", "Single stranded telomeric dna binding", "Sirna binding", "Smad binding", "Small molecule sensor activity", "Small protein activating enzyme binding", "Small ribosomal subunit rrna binding", "Snap receptor activity", "Snare binding", "Snorna binding", "Snrna binding", "Snrnp binding", "Sodium channel regulator activity", "Sodium chloride symporter activity", "Sodium ion binding", "Sodium ion transmembrane transporter activity", "Solute anion antiporter activity", "Solute bicarbonate symporter activity", "Solute cation antiporter activity", "Solute cation symporter activity", "Solute proton antiporter activity", "Solute proton symporter activity", "Solute sodium symporter activity", "Spectrin binding", "Sphingolipid binding", "Sphingolipid transfer activity", "Sphingolipid transporter activity", "Sphingomyelin phosphodiesterase activity", "Sphingosine n acyltransferase activity", "Steroid binding", "Steroid dehydrogenase activity", "Steroid dehydrogenase activity acting on the ch oh group of donors nad or nadp as acceptor", "Steroid hormone binding", "Steroid hormone receptor activity", "Sterol binding", "Sterol esterase activity", "Sterol transfer activity", "Sterol transporter activity", "Structural constituent of cytoskeleton", "Structural constituent of eye lens", "Structural constituent of muscle", "Structural constituent of nuclear pore", "Structural constituent of postsynapse", "Structural constituent of postsynaptic actin cytoskeleton", "Structural constituent of presynaptic active zone", "Structural constituent of ribosome", "Structural constituent of synapse", "Structural molecule activity", "Structural molecule activity conferring elasticity", "Succinate transmembrane transporter activity", "Sulfate binding", "Sulfate transmembrane transporter activity", "Sulfatide binding", "Sulfotransferase activity", "Sulfur compound binding", "Sulfur compound transmembrane transporter activity", "Sulfuric ester hydrolase activity", "Sulfurtransferase activity", "Sumo binding", "Sumo ligase activity", "Sumo specific protease activity", "Sumo transferase activity", "Supercoiled dna binding", "Superoxide dismutase activity", "Superoxide generating nadph oxidase activator activity", "Symporter activity", "Syndecan binding", "Syntaxin 1 binding", "Syntaxin binding", "T cell receptor binding", "Tap binding", "Tat protein binding", "Tau protein binding", "Tau protein kinase activity", "Tbp class protein binding", "Telomerase activity", "Telomerase rna binding", "Telomeric dna binding", "Testosterone dehydrogenase nad p activity", "Testosterone dehydrogenase nadplus activity", "Tetrapyrrole binding", "Tfiib class transcription factor binding", "Tfiid class transcription factor complex binding", "Thiamine pyrophosphate binding", "Thioesterase binding", "Thiol oxidase activity", "Thiolester hydrolase activity", "Thioredoxin disulfide reductase activity", "Threonine type endopeptidase activity", "Threonine type peptidase activity", "Thyroid hormone receptor binding", "Titin binding", "Toll like receptor binding", "Toxic substance binding", "Tpr domain binding", "Transcription coactivator activity", "Transcription coactivator binding", "Transcription coregulator activity", "Transcription coregulator binding", "Transcription corepressor activity", "Transcription corepressor binding", "Transcription elongation regulator activity", "Transcription factor binding", "Transcription regulator activity", "Transcription regulator inhibitor activity", "Transferase activity transferring alkyl or aryl other than methyl groups", "Transferase activity transferring nitrogenous groups", "Transferase activity transferring one carbon groups", "Transferase activity transferring phosphorus containing groups", "Transferase activity transferring sulphur containing groups", "Transferrin receptor binding", "Transforming growth factor beta receptor binding", "Transition metal ion binding", "Transition metal ion transmembrane transporter activity", "Transketolase or transaldolase activity", "Translation activator activity", "Translation elongation factor activity", "Translation factor activity rna binding", "Translation initiation factor activity", "Translation initiation factor binding", "Translation regulator activity", "Translation regulator activity nucleic acid binding", "Translation repressor activity", "Translation repressor activity mrna regulatory element binding", "Translation termination factor activity", "Transmembrane receptor protein kinase activity", "Transmembrane receptor protein tyrosine kinase activity", "Transmembrane transporter binding", "Transporter activity", "Trna binding", "Trna cytosine methyltransferase activity", "Trna guanine methyltransferase activity", "Trna methyltransferase activity", "Trna specific adenosine deaminase activity", "Trna specific ribonuclease activity", "Tropomyosin binding", "Tubulin binding", "Tumor necrosis factor activated receptor activity", "Tumor necrosis factor binding", "Tumor necrosis factor receptor binding", "Tumor necrosis factor receptor superfamily binding", "Type i transforming growth factor beta receptor binding", "U1 snrna binding", "U2 snrna binding", "U3 snorna binding", "U4 snrna binding", "U6 snrna binding", "Ubiquinol cytochrome c reductase activity", "Ubiquinone binding", "Ubiquitin binding", "Ubiquitin conjugating enzyme binding", "Ubiquitin ligase substrate adaptor activity", "Ubiquitin like modifier activating enzyme activity", "Ubiquitin like protein binding", "Ubiquitin like protein conjugating enzyme activity", "Ubiquitin like protein conjugating enzyme binding", "Ubiquitin like protein ligase activity", "Ubiquitin like protein ligase binding", "Ubiquitin like protein specific isopeptidase activity", "Ubiquitin like protein specific protease activity", "Ubiquitin like protein transferase activity", "Ubiquitin protein transferase activator activity", "Ubiquitin protein transferase inhibitor activity", "Ubiquitin protein transferase regulator activity", "Ubiquitin specific protease binding", "Ubiquitin ubiquitin ligase activity", "Ubiquitination like modification dependent protein binding", "Udp galactose beta n acetylglucosamine beta 1 3 galactosyltransferase activity", "Udp glucosyltransferase activity", "Udp glycosyltransferase activity", "Udp xylosyltransferase activity", "Unfolded protein binding", "Unmethylated cpg binding", "Uridine transmembrane transporter activity", "Uridylyltransferase activity", "Vascular endothelial growth factor activated receptor activity", "Vascular endothelial growth factor binding", "Vascular endothelial growth factor receptor 2 binding", "Vascular endothelial growth factor receptor binding", "Very long chain fatty acid coa ligase activity", "Vinculin binding", "Virion binding", "Vitamin b6 binding", "Vitamin binding", "Vitamin d binding", "Vitamin d receptor binding", "Vitamin transmembrane transporter activity", "Voltage gated anion channel activity", "Voltage gated calcium channel activity", "Voltage gated calcium channel activity involved in regulation of cytosolic calcium levels", "Voltage gated cation channel activity", "Voltage gated channel activity", "Voltage gated chloride channel activity", "Volume sensitive anion channel activity", "Water channel activity", "Water transmembrane transporter activity", "Wd40 repeat domain binding", "Wide pore channel activity", "Wnt protein binding", "Ww domain binding", "Xenobiotic transmembrane transporter activity", "Zinc ion binding", "Zinc ion transmembrane transporter activity"], "available_proteins": ["AAMP", "AARS", "AARS2", "AASDHPPT", "AATF", "ABCB1", "ABCB7", "ABCD3", "ABCE1", "ABCF1", "ABCF2", "ABCF3", "ABHD10", "ABHD12", "ABHD6", "ABI1", "ABRAXAS2", "ACAA2", "ACACA", "ACACB", "ACAD9", "ACADM", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACIN1", "ACLY", "ACO2", "ACOT13", "ACOT7", "ACOT9", "ACOX1", "ACOX3", "ACP1", "ACP2", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN2", "ACTN4", "ACTR1A", "ACTR2", "ACTR3", "ADAR", "ADD1", "ADD3", "ADH5", "ADI1", "ADK", "ADNP", "ADPGK", "ADPRHL2", "ADRM1", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGK", "AGL", "AGPAT1", "AGPS", "AHCY", "AHCYL1", "AHNAK", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AK3", "AKAP1", "AKAP12", "AKAP13", "AKAP17A", "AKAP8", "AKAP8L", "AKR1A1", "AKR1B1", "AKR7A2", "AKT2", "ALDH16A1", "ALDH18A1", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALG1", "ALG12", "ALKBH5", "AMOT", "ANAPC1", "ANAPC5", "ANAPC7", "ANKLE2", "ANKRD17", "ANLN", "ANO10", "ANP32A", "ANP32B", "ANXA1", "ANXA11", "ANXA2", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP1M1", "AP1S2", "AP2A1", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3M1", "APEH", "APEX1", "APEX2", "API5", "APLP2", "APMAP", "APOL2", "APP", "APRT", "AQR", "ARCN1", "ARF4", "ARFGAP1", "ARFGAP2", "ARFIP1", "ARFIP2", "ARHGAP17", "ARHGDIA", "ARHGEF2", "ARID1A", "ARIH1", "ARIH2", "ARL1", "ARL10", "ARL2", "ARL3", "ARL6IP1", "ARMT1", "ARPC1A", "ARPC2", "ARPC3", "ARPC4", "ARSA", "ARV1", "ASAH1", "ASCC2", "ASCC3", "ASH2L", "ASNA1", "ASNS", "ASPH", "ASRGL1", "ATAD1", "ATAD3A", "ATAD3B", "ATG3", "ATIC", "ATL2", "ATP13A1", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2C1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6", "ATP6AP1", "ATP6AP2", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1D", "ATP6V1E1", "ATP6V1G1", "ATP6V1H", "ATP7B", "ATPIF1", "ATXN2L", "AUP1", "AURKA", "B4GAT1", "BAG3", "BAG5", "BAG6", "BAIAP2", "BANF1", "BAZ1A", "BAZ1B", "BCAP31", "BCAS3", "BCCIP", "BCLAF1", "BCS1L", "BICD2", "BIRC6", "BLMH", "BLVRA", "BMS1", "BOLA2*", "BOP1", "BPNT1", "BPTF", "BRAP", "BRD1", "BRD2", "BRIX1", "BSG", "BTAF1", "BTF3", "BUB1B", "BUB3", "BUD23", "BUD31", "BYSL", "BZW1", "BZW2", "C1QBP", "C1orf123", "C1orf35", "CAB39", "CACUL1", "CACYBP", "CAD", "CALCOCO1", "CALD1", "CALM3", "CALR", "CALU", "CAMK1", "CAMK2G", "CAND1", "CAND2", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPNS1", "CAPRIN1", "CAPZA1", "CAPZA2", "CAPZB", "CARM1", "CARS", "CASK", "CAST", "CBL", "CBR1", "CBX1", "CBX2", "CBX3", "CBX5", "CCAR1", "CCAR2", "CCDC124", "CCDC22", "CCDC47", "CCDC6", "CCDC86", "CCNB1", "CCNB2", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2AP", "CDC20", "CDC23", "CDC25C", "CDC27", "CDC34", "CDC37", "CDC40", "CDC42", "CDC5L", "CDC73", "CDK1", "CDK2", "CDK4", "CDK5", "CDK5RAP3", "CDK6", "CDKN2AIP", "CDX2", "CEBPZ", "CENPF", "CEP55", "CEPT1", "CERS2", "CETN2", "CFAP20", "CFL1", "CFL2", "CHAC2", "CHAF1A", "CHAF1B", "CHAMP1", "CHCHD3", "CHD4", "CHERP", "CHID1", "CHKA", "CHM", "CHMP2A", "CHMP2B", "CHORDC1", "CHRAC1", "CHST14", "CHUK", "CIAPIN1", "CIP2A", "CIRBP", "CISD2", "CIZ1", "CKAP4", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLASP2", "CLCC1", "CLCN3", "CLCN7", "CLGN", "CLIC1", "CLIC4", "CLINT1", "CLIP1", "CLN5", "CLNS1A", "CLPB", "CLPP", "CLPX", "CLTC", "CLUH", "CMAS", "CMPK1", "CMTR1", "CNDP2", "CNN2", "CNN3", "CNNM4", "CNOT1", "CNOT2", "CNOT4", "CNOT7", "CNOT9", "CNP", "COIL", "COL4A3BP", "COLEC12", "COLGALT1", "COMT", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS2", "COPS4", "COPS5", "COPS6", "COQ3", "COQ8A", "COQ9", "CORO1A", "CORO1C", "CORO7", "COTL1", "COX2", "COX4I1", "COX5A", "COX7A2", "CPD", "CPNE1", "CPNE3", "CPOX", "CPSF1", "CPSF3", "CPSF6", "CPSF7", "CPT2", "CPVL", "CRK", "CRKL", "CRNKL1", "CRTAP", "CRYZ", "CS", "CSDE1", "CSE1L", "CSGALNACT2", "CSK", "CSNK1A1", "CSNK2A1", "CSNK2A2", "CSNK2B", "CSTB", "CSTF1", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTBS", "CTH", "CTNNA1", "CTNNAL1", "CTNNB1", "CTNND1", "CTPS1", "CTPS2", "CTSA", "CTSB", "CTSC", "CTTN", "CTU2", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CWF19L1", "CXADR", "CXorf57", "CYB5B", "CYB5D2", "CYB5R1", "CYB5R3", "CYC1", "CYFIP1", "CYP20A1", "CYP51A1", "DAP3", "DARS", "DARS2", "DAZAP1", "DBN1", "DBNL", "DCAF1", "DCAF7", "DCAKD", "DCD", "DCPS", "DCTN1", "DCTN2", "DCTN3", "DCTN4", "DCTPP1", "DCUN1D4", "DCXR", "DDB1", "DDI2", "DDOST", "DDRGK1", "DDT", "DDX1", "DDX10", "DDX17", "DDX18", "DDX20", "DDX21", "DDX23", "DDX24", "DDX27", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX50", "DDX51", "DDX52", "DDX54", "DDX56", "DDX6", "DEK", "DENR", "DERL1", "DFFA", "DHCR24", "DHCR7", "DHFR", "DHRS1", "DHRS7", "DHX15", "DHX16", "DHX29", "DHX30", "DHX36", "DHX37", "DHX8", "DHX9", "DIAPH1", "DIAPH2", "DIAPH3", "DIDO1", "DIEXF", "DIMT1", "DIS3", "DKC1", "DLAT", "DLD", "DLST", "DNA2", "DNAAF5", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJC1", "DNAJC10", "DNAJC2", "DNAJC3", "DNAJC7", "DNAJC8", "DNAJC9", "DNASE2", "DNM1L", "DNM2", "DNMT1", "DNPH1", "DNTTIP2", "DOCK7", "DOHH", "DPH2", "DPH5", "DPM1", "DPP3", "DPP9", "DPY30", "DPYSL2", "DPYSL5", "DR1", "DRG1", "DRG2", "DSC1", "DSC3", "DSG2", "DSP", "DST", "DSTN", "DTYMK", "DUSP12", "DUSP3", "DUSP9", "DUT", "DYNC1H1", "DYNC1LI1", "DYNC1LI2", "DYNC2H1", "DYNLL1", "EBNA1BP2", "ECD", "ECE1", "ECH1", "ECHS1", "ECI1", "ECI2", "EDC3", "EDF1", "EEF1A2", "EEF1B2", "EEF1D", "EEF1G", "EEF2", "EFHD1", "EFL1", "EFTUD2", "EHD1", "EHD4", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2D", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A3", "EIF4B", "EIF4E", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "ELAC2", "ELAVL1", "ELMO2", "ELMOD2", "ELOB", "ELOC", "ELP1", "ELP2", "ELP3", "ELP4", "EMC1", "EMC2", "EMC7", "EMD", "EMG1", "ENAH", "ENDOD1", "ENO1", "ENO2", "ENSA", "EPB41", "EPB41L2", "EPB41L5", "EPDR1", "EPHA7", "EPHX1", "EPHX2", "EPPK1", "EPRS", "EPS15", "EPS15L1", "ERAL1", "ERAP1", "ERCC2", "ERG28", "ERGIC3", "ERH", "ERI1", "ERLIN1", "ERLIN2", "ERMP1", "ERO1A", "ERP29", "ESD", "ESF1", "ESYT1", "ETF1", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXO1", "EXOC2", "EXOC3", "EXOC5", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "EZR", "FAF1", "FAF2", "FAHD1", "FAM129B", "FAM208A", "FAM213A", "FAM49B", "FAM98B", "FANCI", "FAR1", "FARSA", "FARSB", "FASN", "FAU", "FBL", "FBXO22", "FBXO7", "FCGRT", "FDFT1", "FDPS", "FECH", "FEN1", "FGFR1OP", "FH", "FHOD1", "FIP1L1", "FIS1", "FKBP10", "FKBP14", "FKBP1A", "FKBP3", "FKBP4", "FKBP5", "FKBP7", "FKBP8", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FMR1", "FN3KRP", "FNTB", "FOXRED1", "FRG1", "FSCN1", "FTO", "FTSJ3", "FUBP1", "FUBP3", "FUCA1", "FUCA2", "FUNDC2", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GAK", "GALK1", "GALM", "GALNT1", "GALNT2", "GALNT7", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GBA", "GBF1", "GCAT", "GCDH", "GCLC", "GCLM", "GCN1", "GDI1", "GDI2", "GDPD1", "GEMIN4", "GEMIN5", "GET4", "GFM1", "GFPT1", "GGCT", "GGCX", "GGH", "GHDC", "GIGYF2", "GLA", "GLB1", "GLDC", "GLG1", "GLMN", "GLO1", "GLOD4", "GLRX", "GLRX3", "GLRX5", "GLS", "GLUD1", "GLYR1", "GM2A", "GMFB", "GMPPB", "GMPS", "GNA13", "GNAI1", "GNAI2", "GNAI3", "GNL1", "GNL2", "GNL3", "GNL3L", "GNPAT", "GNPDA1", "GNS", "GOLGA3", "GOLGB1", "GOPC", "GOT1", "GOT2", "GPAM", "GPATCH4", "GPD2", "GPI", "GPKOW", "GPR107", "GPS1", "GRB2", "GRHPR", "GRIPAP1", "GRPEL1", "GRSF1", "GRWD1", "GSK3B", "GSPT1", "GSR", "GSS", "GSTK1", "GSTM3", "GSTO1", "GSTZ1", "GTF2I", "GTF3C4", "GTPBP1", "GTPBP10", "GTPBP3", "GTPBP4", "GUF1", "GUSB", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACD3", "HACL1", "HADH", "HADHA", "HADHB", "HAT1", "HAUS8", "HBS1L", "HCCS", "HCFC1", "HDAC2", "HDGF", "HDGFL2", "HDHD2", "HDLBP", "HEATR1", "HEATR3", "HEBP1", "HEBP2", "HECTD1", "HECTD3", "HELLS", "HEXA", "HEXB", "HIBADH", "HIBCH", "HIF1AN", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HLTF", "HM13", "HMBS", "HMCES", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMGCS1", "HMGN2", "HMOX1", "HMOX2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPLL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HNRNPUL2", "HP1BP3", "HPF1", "HPRT1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSDL1", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA13", "HSPA14", "HSPA1B", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPB1", "HSPBP1", "HSPD1", "HSPE1", "HSPH1", "HTATIP2", "HUWE1", "HYOU1", "IARS", "IARS2", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDI1", "IFT27", "IGBP1", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IK", "ILF2", "ILF3", "ILKAP", "ILVBL", "IMMT", "IMP4", "IMPACT", "IMPDH1", "IMPDH2", "INA", "INCENP", "INTS11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IRF2BPL", "IRGQ", "IRS4", "ISCU", "IST1", "ISYNA1", "ITGB1", "ITM2C", "ITPA", "IVD", "JUP", "KARS", "KCTD12", "KCTD5", "KDELC2", "KDELR1", "KDM1A", "KDM1B", "KDM3B", "KDSR", "KHDRBS1", "KHSRP", "KIAA0368", "KIAA0391", "KIAA1147", "KIF11", "KIF15", "KIF18B", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF4A", "KIF5B", "KIF7", "KIFBP", "KIFC1", "KLC1", "KMT2A", "KNTC1", "KPNA1", "KPNA2", "KPNA3", "KPNB1", "KRI1", "KRR1", "KTN1", "LAMP1", "LAMTOR1", "LANCL2", "LAP3", "LARP1", "LARP4", "LARP4B", "LARS", "LARS2", "LAS1L", "LASP1", "LBR", "LCLAT1", "LDAH", "LDHA", "LDHB", "LEMD2", "LEMD3", "LETM1", "LGALS3", "LGALS3BP", "LGMN", "LIG1", "LIG3", "LIMA1", "LIPA", "LLGL1", "LMAN1", "LMAN2", "LMNB1", "LMNB2", "LNPEP", "LONP1", "LPCAT1", "LPCAT3", "LPGAT1", "LRBA", "LRPPRC", "LRRC40", "LRRC47", "LRRC59", "LRWD1", "LSM14B", "LSM2", "LSM6", "LSM7", "LSS", "LTA4H", "LTN1", "LUC7L2", "LUC7L3", "LYAR", "LYPLA1", "M6PR", "MACF1", "MAD2L1", "MAN2A1", "MAN2B1", "MANBA", "MANF", "MAP1B", "MAP1S", "MAP2K1", "MAP4", "MAPK1", "MAPRE1", "MAPRE2", "MARC1", "MARCKS", "MARS", "MAT2A", "MAT2B", "MATR3", "MAVS", "MBD3", "MBOAT7", "MCAT", "MCCC1", "MCCC2", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCMBP", "MCU", "MDC1", "MDH1", "MDH2", "MDN1", "ME1", "MECP2", "MED1", "MED21", "MED23", "MED24", "MED25", "MED4", "MFN2", "MFSD10", "MFSD3", "MFSD5", "MGEA5", "MGST2", "MGST3", "MICU1", "MID1", "MIF", "MINDY3", "MINPP1", "MIPEP", "MKI67", "MKRN2", "MLEC", "MMGT1", "MMS19", "MOGS", "MORF4L1", "MOV10", "MPC2", "MPHOSPH10", "MPHOSPH6", "MPI", "MPRIP", "MPST", "MRE11", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL14", "MRPL15", "MRPL19", "MRPL21", "MRPL28", "MRPL3", "MRPL37", "MRPL39", "MRPL40", "MRPL44", "MRPL45", "MRPL46", "MRPL47", "MRPL49", "MRPL9", "MRPS11", "MRPS2", "MRPS22", "MRPS23", "MRPS25", "MRPS27", "MRPS28", "MRPS30", "MRPS31", "MRPS33", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRPS9", "MRTO4", "MSH2", "MSH3", "MSH6", "MSI2", "MSN", "MTA1", "MTA2", "MTAP", "MTCH1", "MTDH", "MTHFD1", "MTHFD1L", "MTHFD2", "MTMR2", "MTMR6", "MTOR", "MTPAP", "MTPN", "MTR", "MVK", "MYBBP1A", "MYCBP", "MYG1", "MYH10", "MYH14", "MYH9", "MYL6", "MYO1B", "MYO1C", "MYO1D", "MYO6", "NAA15", "NAA25", "NAA40", "NAA50", "NAE1", "NAF1", "NAGLU", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NAPG", "NARS", "NASP", "NAT10", "NAXE", "NBN", "NCAPD2", "NCAPG", "NCAPH", "NCBP1", "NCKAP1", "NCKIPSD", "NCL", "NCLN", "NCOA5", "NCSTN", "NDC1", "NDUFA10", "NDUFA3", "NDUFA4", "NDUFA5", "NDUFA7", "NDUFA9", "NDUFAF4", "NDUFAF7", "NDUFB10", "NDUFB3", "NDUFB4", "NDUFB5", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS6", "NDUFS7", "NDUFV1", "NDUFV2", "NEFL", "NEFM", "NEK9", "NELFA", "NELFB", "NELFCD", "NELFE", "NEMF", "NENF", "NES", "NFU1", "NHP2", "NIFK", "NIPBL", "NKRF", "NLN", "NMD3", "NME1", "NME6", "NME7", "NMT1", "NNT", "NOB1", "NOC2L", "NOC3L", "NOC4L", "NOL10", "NOL11", "NOL6", "NOL7", "NOL9", "NOLC1", "NOM1", "NONO", "NOP14", "NOP2", "NOP53", "NOP56", "NOP58", "NOSIP", "NPC1", "NPC2", "NPEPPS", "NPLOC4", "NPM1", "NRDC", "NRP1", "NSA2", "NSD2", "NSDHL", "NSF", "NSFL1C", "NSUN2", "NSUN5", "NT5C2", "NT5C3B", "NT5DC1", "NT5DC2", "NTHL1", "NTMT1", "NTPCR", "NUBP2", "NUCB1", "NUCB2", "NUCKS1", "NUDC", "NUDCD2", "NUDT1", "NUDT12", "NUDT21", "NUDT5", "NUF2", "NUFIP2", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP160", "NUP188", "NUP205", "NUP214", "NUP54", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NUPL2", "NVL", "NXF1", "NXN", "OAT", "OCLN", "OCRL", "OGDH", "OGT", "OLA1", "OPA1", "OSBP", "OSBPL8", "OSBPL9", "OSGEP", "OTUB1", "OTULIN", "OXA1L", "OXSR1", "P3H1", "P3H4", "P4HA1", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PAF1", "PAFAH1B1", "PAFAH1B2", "PAFAH1B3", "PAICS", "PAK1", "PAK2", "PANK4", "PAPOLA", "PAPSS1", "PARK7", "PARN", "PARP1", "PATL1", "PBK", "PBRM1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCK2", "PCLAF", "PCM1", "PCMT1", "PCNA", "PCYOX1", "PDAP1", "PDCD11", "PDCD4", "PDCD5", "PDCD6", "PDCD6IP", "PDCL3", "PDE12", "PDE6D", "PDHA1", "PDHB", "PDIA3", "PDIA4", "PDIA6", "PDK1", "PDK3", "PDLIM1", "PDLIM3", "PDLIM5", "PDLIM7", "PDPR", "PDRG1", "PDXDC1", "PDXK", "PEBP1", "PECR", "PEF1", "PELO", "PELP1", "PEPD", "PES1", "PEX14", "PEX19", "PFAS", "PFDN2", "PFDN4", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGGT1B", "PGK1", "PGLS", "PGM1", "PGM2", "PGM3", "PGP", "PGRMC1", "PGRMC2", "PHB", "PHB2", "PHF5A", "PHF6", "PHF8", "PHGDH", "PHIP", "PHKA1", "PICALM", "PIH1D1", "PIK3C2A", "PIK3R4", "PIN1", "PIN4", "PIP4K2C", "PIR", "PISD", "PITPNB", "PITRM1", "PKM", "PKMYT1", "PKN2", "PLA2G15", "PLAA", "PLBD2", "PLCG1", "PLD3", "PLD6", "PLEC", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLS3", "PM20D2", "PMPCA", "PMPCB", "PNN", "PNO1", "PNP", "PNPT1", "POLA1", "POLD1", "POLD3", "POLDIP2", "POLDIP3", "POLE", "POLE3", "POLE4", "POLR1A", "POLR1B", "POLR1E", "POLR2A", "POLR2B", "POLR2C", "POLR2G", "POLR3A", "POLR3C", "POLRMT", "PON2", "POP1", "POR", "PPA1", "PPA2", "PPAN", "PPAT", "PPHLN1", "PPIB", "PPID", "PPIF", "PPIG", "PPIH", "PPIL4", "PPM1G", "PPME1", "PPP1CA", "PPP1CB", "PPP1R10", "PPP1R7", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP4C", "PPP4R1", "PPP5C", "PPP6C", "PPT1", "PPT2", "PQBP1", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PREP", "PREPL", "PRIM1", "PRIM2", "PRKAG1", "PRKAR1A", "PRKAR2A", "PRKCD", "PRKCSH", "PRKDC", "PRKRA", "PRMT1", "PRMT3", "PRMT5", "PRMT9", "PRPF19", "PRPF3", "PRPF31", "PRPF38B", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPS1", "PRPSAP1", "PRPSAP2", "PRRC1", "PRRC2A", "PRRC2C", "PSAP", "PSAT1", "PSIP1", "PSMA1", "PSMA3", "PSMA4", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD6", "PSMD7", "PSME1", "PSME2", "PSME3", "PSME4", "PSMF1", "PSMG1", "PSMG2", "PSPC1", "PTBP1", "PTBP2", "PTCD1", "PTCD3", "PTDSS1", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK7", "PTPA", "PTPN1", "PTPN11", "PTRH2", "PTRHD1", "PUF60", "PUM3", "PURA", "PUS1", "PUS7", "PWP1", "PWP2", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QDPR", "QKI", "QSOX2", "RAB10", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB21", "RAB23", "RAB24", "RAB2A", "RAB35", "RAB3GAP2", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RAB8A", "RABGAP1", "RABGGTA", "RABL6", "RAC1", "RACGAP1", "RACK1", "RAD21", "RAD23A", "RAD23B", "RAD50", "RAE1", "RAI14", "RALA", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP9", "RANGAP1", "RANGRF", "RAP2B", "RAPGEF2", "RARS", "RARS2", "RAVER1", "RB1", "RBBP4", "RBBP6", "RBBP7", "RBM10", "RBM12", "RBM12B", "RBM14", "RBM17", "RBM19", "RBM22", "RBM25", "RBM26", "RBM27", "RBM28", "RBM3", "RBM34", "RBM39", "RBM4", "RBM5", "RBM8A", "RBMX", "RCC1", "RCC2", "RCL1", "RCN1", "RCN2", "RCOR1", "RDH11", "RDH13", "RDX", "RECQL", "REEP4", "RELA", "REPS1", "RER1", "RETSAT", "REXO4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RHEB", "RHOT1", "RHOT2", "RIDA", "RIOK2", "RIOX1", "RMDN3", "RNASEH2A", "RNASET2", "RNF2", "RNF40", "RNH1", "RNPEP", "ROCK1", "ROCK2", "RPA1", "RPA2", "RPAP1", "RPF2", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPN1", "RPN2", "RPP30", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RRBP1", "RRM1", "RRM2", "RRP1", "RRP12", "RRP1B", "RRP8", "RRS1", "RSF1", "RSL1D1", "RSL24D1", "RTCB", "RTN4", "RTRAF", "RUFY1", "RUVBL1", "RUVBL2", "S100A10", "S100A11", "S100A13", "SACM1L", "SAE1", "SAFB", "SAFB2", "SAMHD1", "SAP18", "SAR1A", "SARNP", "SARS", "SARS2", "SART1", "SART3", "SBDS", "SC5D", "SCAMP3", "SCARB1", "SCARB2", "SCCPDH", "SCD", "SCFD1", "SCML2", "SCO1", "SCO2", "SCP2", "SCPEP1", "SCRIB", "SCRN1", "SDCBP", "SDE2", "SDF4", "SDHA", "SDHB", "SDR39U1", "SEC11A", "SEC22B", "SEC23A", "SEC23IP", "SEC24A", "SEC24B", "SEC24C", "SEC24D", "SEC31A", "SEC61A1", "SEC61B", "SEC61G", "SEC62", "SEC63", "SEH1L", "SENP3", "SEPHS1", "SEPT2", "SEPT7", "SEPT9", "SERBP1", "SERPINB6", "SERPINH1", "SET", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFSWAP", "SFXN1", "SFXN2", "SFXN4", "SGPL1", "SGTA", "SH3GL1", "SH3GLB1", "SH3PXD2B", "SHCBP1", "SHMT1", "SHMT2", "SHOC2", "SIGMAR1", "SIL1", "SIN3A", "SKIV2L", "SKIV2L2", "SKP1", "SKP2", "SLC12A2", "SLC12A9", "SLC16A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A17", "SLC25A19", "SLC25A20", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A4", "SLC25A42", "SLC25A44", "SLC25A5", "SLC25A6", "SLC27A2", "SLC27A4", "SLC29A1", "SLC30A5", "SLC35A4", "SLC35B2", "SLC35F1", "SLC35F2", "SLC38A2", "SLC3A2", "SLC4A1AP", "SLC4A7", "SLC9A3R1", "SLFN11", "SLIRP", "SLIT2", "SLK", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC6", "SMCHD1", "SMN1*", "SMNDC1", "SMPD4", "SMYD3", "SND1", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPC", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNW1", "SNX1", "SNX2", "SNX27", "SNX3", "SNX5", "SNX6", "SNX9", "SOD2", "SON", "SORT1", "SPAG9", "SPART", "SPATA5", "SPATA5L1", "SPCS2", "SPEN", "SPNS1", "SPPL2A", "SPR", "SPTAN1", "SPTBN1", "SPTBN2", "SPTLC1", "SPTLC2", "SQLE", "SQSTM1", "SRCAP", "SREK1", "SRI", "SRM", "SRP14", "SRP54", "SRP68", "SRP72", "SRP9", "SRPK1", "SRPRA", "SRPRB", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF2", "SRSF3", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSNA1", "SSRP1", "STAG2", "STAM", "STAMBP", "STARD3", "STARD3NL", "STARD7", "STAT1", "STAT3", "STAU1", "STAU2", "STIP1", "STMN1", "STOM", "STOML2", "STRAP", "STRBP", "STT3A", "STT3B", "STUB1", "STX18", "STX4", "STX5", "STX7", "STX8", "STXBP3", "STXBP4", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGP2", "SUGT1", "SUN1", "SUPT16H", "SUPT5H", "SUPT6H", "SUPV3L1", "SURF4", "SURF6", "SUZ12", "SYNCRIP", "SYNE2", "TACO1", "TAF15", "TAF6L", "TAGLN2", "TALDO1", "TAMM41", "TARDBP", "TARS", "TARS2", "TBC1D13", "TBC1D15", "TBC1D4", "TBC1D9B", "TBCA", "TBCD", "TBCE", "TBL2", "TBL3", "TBRG4", "TCEA1", "TCERG1", "TCOF1", "TCP1", "TDP2", "TDRKH", "TECR", "TELO2", "TERF2IP", "TEX264", "TFAM", "TFCP2", "TFG", "TFRC", "THOC1", "THOC2", "THOC3", "THOC6", "THOP1", "THRAP3", "THUMPD1", "THUMPD3", "TIAL1", "TIGAR", "TIMM13", "TIMM17A", "TIMM17B", "TIMM23", "TIMM44", "TIMM50", "TIMM8A", "TIMM8B", "TJP1", "TK1", "TKT", "TLN1", "TMCO1", "TMED10", "TMED9", "TMEM109", "TMEM192", "TMEM43", "TMOD3", "TMPO", "TMPO", "TMSB4X", "TMTC3", "TMX1", "TMX2", "TNPO1", "TNPO3", "TOE1", "TOLLIP", "TOM1", "TOMM20", "TOMM22", "TOMM34", "TOMM40", "TOMM70", "TOP1", "TOP2A", "TOP2B", "TOR1AIP1", "TOR1AIP2", "TOX4", "TP53", "TP53BP2", "TPD52", "TPD52L2", "TPI1", "TPM1", "TPM3", "TPM4", "TPP1", "TPP2", "TPR", "TPT1", "TPX2", "TRA2A", "TRA2B", "TRAF2", "TRAM1", "TRAP1", "TRIM21", "TRIM25", "TRIM28", "TRIM33", "TRIO", "TRIP12", "TRIP13", "TRMT10C", "TRMT1L", "TRMT6", "TROVE2", "TRUB1", "TSFM", "TSG101", "TSN", "TSNAX", "TSPO", "TSR1", "TTC1", "TTC26", "TTC4", "TTK", "TTLL12", "TTYH3", "TUBB", "TUBB2A", "TUBB2B", "TUBB4A", "TUBB4B", "TUBB6", "TUBGCP2", "TUBGCP3", "TUFM", "TWF1", "TWF2", "TXLNA", "TXLNG", "TXNDC12", "TXNDC17", "TXNDC5", "TXNDC9", "TXNL1", "TXNRD1", "TYMS", "U2AF2", "U2SURP", "UAP1", "UBA1", "UBA2", 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sha256:75307444ae199f824c15e1713e548cab3d312743d76e35cc71ac109ebaeeb598 +size 149320 diff --git a/msigdb_hp/df_merge.tsv b/msigdb_hp/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..50b591d8c31d2b4a898acc4c2fc45073e108a933 --- /dev/null +++ b/msigdb_hp/df_merge.tsv @@ -0,0 +1,104 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Mental deterioration 35 89 3.3975121454132258 0.0006800156933344 26.16990291262136 97.51699029126212 1.0638646072845834 0.3178098854339388 8.217921866043707 8.355116022963852 1.9487627742005753 0.3762024781602087 1.6587341140457443e-08 2.189956478289484e-06 2.355459475449993e-05 2.908712822690728e-08 2.495355446742197e-09 +Splenomegaly 29 76 3.0615882863727126 0.0022016605364052 20.660194174757283 86.74029126213593 0.5649049994066069 0.3835571498509289 6.419862077062851 7.868335701486235 1.546158503499524 0.3590721878602594 6.326471096670616e-06 0.0048423585336687 7.179090621618829e-05 7.820724558014526e-07 7.230761429323273e-07 +Clumsiness 10 18 2.859686962259373 0.0042405937140641 6.75 20.57766990291262 0.9027704056640264 0.2559090219975202 2.4698423753801175 2.2221930931993956 1.527926415027724 0.282470536898918 6.074037232870264e-06 0.0230489069918226 0.0115248505447769 2.0229101637934145e-05 1.6841870077886987e-05 +Abnormality of the upper respiratory tract 16 78 2.851387602760324 0.0043528872405629 19.66504854368932 95.80582524271844 0.4534569687157453 0.5959175600884278 6.924659870205313 10.36312380503997 0.9632839800839448 0.3651113920771414 0.0038583801547247 0.1694970960273094 0.0237063834265816 0.0008610297682648 0.0048164219114183 +Supranuclear gaze palsy 6 16 2.810915141481126 0.0049400813086095 5.186893203883495 19.1626213592233 0.8242716574954257 0.3183493558985887 2.2612229396433574 2.139608194404574 1.2188387108542005 0.2935859783151378 0.0002329480420708 0.01497108596825 0.0538434207197609 3.566586302683105e-05 0.000466746230466 +Cherry red spot of the macula 6 9 2.7279753242994045 0.0063724374725842 4.87621359223301 9.031553398058252 0.4125318500531191 0.1346012745180574 1.6566187440434876 0.4477283705000042 2.101542046986786 0.2228325403979826 7.2682811797451315e-09 2.2261381171916983e-05 5.558079816224799e-08 3.213939723308515e-09 1.1973446501175916e-08 +Abnormality of corneal stroma 6 11 2.700417695676085 0.0069252469546341 4.733009708737864 13.131067961165048 0.6716440045814968 0.2233795964932449 1.7589100966397004 2.506749302052849 1.61853564814875 0.2527544669587041 0.0016054918682004 0.2480154974279715 0.0024373211620913 0.0005241078784284 0.0231914212352716 +Dysostosis multiplex 6 7 2.64432749451968 0.0081853417514221 3.983009708737864 7.990291262135922 0.4150973501220912 0.1595724105588133 1.65382835361071 1.246316090990369 1.8479195153421644 0.2123242141003258 1.0160367433853411e-05 0.0044823878286489 1.3333677979165398e-06 3.913848371975639e-07 3.857148929638639e-05 +Abnormal tissue metabolite concentration 4 13 2.635942005119848 0.0083904070441243 5.895631067961165 14.650485436893204 0.4799987914691458 0.2340469593783387 2.3926019349714145 2.328417679576543 1.7567023743300048 0.2768423789344761 0.0012572623322763 0.0005142462303242 0.0002651548018521 0.0010916803236277 0.0008544422426654 +Pathologic fracture 7 15 2.616151873236898 0.0088926993837046 4.257281553398058 15.072815533980584 0.983166532607372 0.3143076297274698 2.133145812327421 2.2800397788540345 1.0713003315034937 0.2893419439464214 0.4352241640586226 0.1715759324473242 0.3143397790261298 0.0678108138951911 0.000466746230466 +Ascites 10 25 2.581214820411032 0.0098453296576324 6.538834951456311 25.800970873786408 0.2860997134153194 0.2561597752608451 2.6559964399945706 3.331112387328855 1.6846905274497244 0.2824645045304154 0.0036343764367394 0.0455724387921432 0.1487873266068847 7.315214899305124e-06 0.0005644273119408 +Abnormal morphology of the conjunctival vasculature 3 7 2.5562372958339066 0.0105810934024825 2.6359223300970873 7.330097087378641 0.3791669082255805 0.3264494094231241 1.4642904354684148 1.4524057679745994 1.3542312898692437 0.2989163062985944 0.0001394367354527 0.0036723611473879 2.7844996115802127e-05 0.0009779431698101 0.0118045746321095 +Abnormality of extrapyramidal motor function 21 64 2.545692870827159 0.0109061096901581 17.723300970873787 74.23058252427184 0.6611914449106878 0.5008095396366101 5.517064505158221 6.985611887807198 1.1554912414277594 0.3847143245763222 0.0099746866220343 0.0166094571106189 0.0473694372220574 3.7315008605804414e-05 0.0003804445534375 +Abnormal form of the vertebral bodies 20 75 2.5251751589080205 0.0115640635637541 19.968446601941743 83.88349514563107 0.6644002102675167 0.5345165392282933 7.187939907318809 8.37593753149639 0.9881357365384656 0.3722270618536288 0.0670546193676057 0.3318756245741759 0.0880352084429709 0.0009456035437881 0.0040653134860602 +Exaggerated startle response 3 7 2.5071683266152007 0.012170273943401 2.987864077669903 8.699029126213592 0.0610274034602423 0.2634753902852135 1.4337635656228835 1.0620090089420118 1.617556501702403 0.2831541938798349 0.0011997221286668 0.0022827689145391 0.0003602808960722 0.000371706641515 0.0048470794580564 +Abnormal urine carbohydrate level 4 12 2.488508361660415 0.0128280220590655 3.883495145631068 11.70631067961165 -0.1388020161424021 0.4168246977061866 1.9096127339504616 1.3287920569685254 1.2303643442685093 0.3136870898203888 0.0007633123732652 0.0084566179175882 0.0026246094830452 0.0005910649168726 0.0118390941536887 +Disproportionate short stature 9 20 2.482139409753441 0.0130596170662951 8.58252427184466 24.70145631067961 1.4449047806081987 0.2464238748623315 3.3320283680556178 3.793287097673045 1.0910515137563812 0.2952991105687103 0.139094754037064 0.3498897642406863 0.0540767090111314 0.0057382004919105 0.0106711467616426 +Abnormal circulating lipid concentration 19 64 2.476287542540577 0.0132756611183162 21.0995145631068 75.44417475728156 1.321442689138656 0.3287247628796158 8.33534407984455 6.5596064623065375 1.4065018349702674 0.365722219395451 0.0002067780549984 0.0501087549876423 0.0002510269571156 1.914367861249678e-05 3.074847898923124e-05 +Oligosacchariduria 4 6 2.461741601878489 0.0138264239784473 2.4611650485436893 4.978155339805825 0.0914492290535993 0.2254706360721404 1.281286747781515 0.9537908500181173 1.6653598868357138 0.2594196870884814 2.852324428860232e-06 0.0006219606051344 4.656667989155393e-05 4.228937316679017e-07 1.2976991690069218e-05 +Abnormal conjunctiva morphology 8 24 2.4592848886035545 0.013921409727639 6.997572815533981 26.58495145631068 0.5265054436970301 0.4429378103171669 2.669041123051977 2.4927208099742058 1.133049116684961 0.3300379664677785 0.000448162945771 0.0761999214167486 0.002167548947337 0.0004757717240761 0.0164186077138823 +Loss of speech 6 21 2.4456710428065773 0.01445828506044 5.453883495145631 19.1626213592233 0.4726173662677797 0.3013153148889984 2.223071754411353 1.8941045281154043 1.521023928928509 0.3006842241053739 0.0003323540822832 0.0010496761988569 0.0006788789579845 5.880242055622103e-05 0.0001455639700759 +Arteriosclerosis 6 13 2.437198148082936 0.0148015661226337 4.885922330097087 14.944174757281552 0.0721468675738393 0.2032976413320727 1.852339343238996 2.0572604199467093 1.788928597657784 0.2405012300780825 0.0006238845233945 0.0221752921752284 0.0108939889611676 0.0001418153943193 0.0078773866774108 +Abnormal lower motor neuron morphology 3 9 2.408687646999633 0.0160099936294255 2.1771844660194173 8.701456310679612 0.8468629004048428 0.2893246976958152 1.3759952567341256 1.207057649999096 1.1584035743641086 0.2695692447215745 0.0054540651163694 1.0 1.0 0.0028478177309091 0.0306674579519183 +Progressive neurologic deterioration 9 21 2.4063839168992622 0.0161113234055705 6.75 20.466019417475728 0.5813429756502071 0.2930928839947513 2.6727908035631316 1.300228015706032 1.5791549964390388 0.3142214461904322 0.0033897445691462 0.0180235679120217 0.0080456420559546 0.0036383017284534 2.938812499918237e-05 +Urinary glycosaminoglycan excretion 4 6 2.395827215946801 0.0165829053597852 2.9490291262135924 6.563106796116505 0.4749855796693131 0.2196485727407601 1.2846457065606351 0.9261036754709504 1.6390629541794843 0.2603486997442626 5.137753109661152e-05 0.0022827689145391 1.0100053103379697e-05 1.972516813028553e-05 0.0005240184523993 +Mucosal telangiectasiae 3 7 2.373002425929524 0.0176441480357252 3.2354368932038833 9.689320388349516 0.8501086222195428 0.291727970426265 1.410916714116348 1.5996305775803197 1.2598794700933909 0.2907637890882055 0.0075261912037519 0.0078974776787256 0.0023694947377154 0.0043549454623746 0.0443313868612348 +Increased cerebral lipofuscin 3 5 2.365405072320018 0.0180103598141914 3.0970873786407767 5.118932038834951 1.0434065701738664 0.1270836154757583 1.1278862704044743 0.4599818751628888 1.7720117842909846 0.2267161680252343 8.364969714787759e-06 1.2225095413484733e-05 1.612359251599596e-06 6.292953854873037e-05 5.383729574080712e-05 +Areflexia of lower limbs 10 21 2.350045891622309 0.018771096584436 6.601941747572815 21.186893203883496 0.8014885285213843 0.4297204254543569 3.042066893889402 3.372723692373783 0.977277602505203 0.3249512351298445 0.028877175146641 1.0 1.0 0.0247625444605767 8.799970808454681e-06 +Severe short stature 3 18 2.3420265768798645 0.0191793491283618 5.997572815533981 23.890776699029125 0.6572048998571618 0.4085599295800764 2.761119431778089 3.4934352273944844 1.0243280415736038 0.3082890569118746 0.0324095800344955 0.3306605597140526 0.0455644056460713 0.1418336443700749 0.3753819864549536 +Foam cells 5 6 2.340723968107388 0.0192463907846334 2.9611650485436893 5.398058252427185 -0.064606162326146 0.1366553329191208 1.1817572081322671 0.893230265545378 1.9405286208577948 0.1862104272675829 2.852324428860232e-06 0.0006219606051344 0.002465796513642 5.1173118255718285e-09 3.235576349203615e-07 +Limb ataxia 7 22 2.33962465100773 0.0193031288550142 6.597087378640777 24.114077669902912 0.989869123864314 0.3154216467413447 2.5039369509835696 2.8496458430585005 1.1323309577692284 0.292147514752726 0.0016054918682004 0.2480154974279715 0.018985818871393 0.0005241078784284 0.0019750620012024 +Amyotrophic lateral sclerosis 6 15 2.336280919761098 0.0194766052809658 4.453883495145631 16.203883495145632 1.0855969203541704 0.3037117925086244 2.3812188822255287 1.5445439412417563 1.0118111691913367 0.2917679915833991 0.1190390679918941 1.0 1.0 0.016869226769582 0.0032176405980257 +Dementia 18 54 2.331382431398977 0.0197332030832089 17.021844660194176 58.19174757281554 0.9978727756866732 0.3214313161707923 5.814027938449679 5.568168011495494 1.793982160512653 0.3770196158976925 6.562500866045032e-07 0.0004828847033112 0.0020186844379805 1.0598235404361051e-06 9.092227468864567e-06 +Ectopic calcification 14 51 2.329217818027148 0.0198475294494548 13.553398058252426 56.53155339805825 0.5275931647443897 0.4410566614950294 4.995100814049753 5.994858194438004 1.2985638579898735 0.3743313818119885 0.0057406873675229 0.1587221484945262 0.0005411829706675 0.0002474264599681 0.0021376258736728 +Abnormal vertebral morphology 25 96 2.308658986610838 0.020962511917119 25.18446601941747 107.1383495145631 0.7050611944944222 0.5078087978506296 8.434496402822974 10.278065304429203 1.0858158093436174 0.3796440707216367 0.0426721101919636 0.1972614733392075 0.0337323180421229 9.417299410115936e-05 0.003364177985801 +Rhizomelia 7 11 2.299349357676447 0.0214851091750516 4.276699029126213 11.868932038834952 1.3783619481702345 0.228956695884812 2.09278482575067 1.6655579622091714 0.936017394236602 0.2616202806826952 0.1435485262919318 1.0 0.0720571885403784 0.0247625444605767 0.022687625976848 +Increased circulating lactate dehydrogenase concentration 3 13 2.2991788062832472 0.0214947879725762 3.1092233009708736 14.009708737864075 -0.0898359396000094 0.4215562670860733 1.75300363001213 1.740411432392157 1.117422097583478 0.2860320368252682 0.0091327046021892 1.0 0.2518545844225215 0.0056128198685199 0.0550493127109652 +Abnormal macrophage morphology 4 5 2.295617332993574 0.021697770833549 2.9150485436893203 5.640776699029126 -0.1129741045260028 0.144980672561322 1.3090672390975422 1.117854819168669 1.9286041303300476 0.1913667515871486 6.773250277453748e-05 0.0026008925831016 0.0100519320580488 2.812625820330817e-05 0.000732082482726 +Psychomotor deterioration 3 9 2.2942307071413035 0.021777250362492 3.2645631067961167 8.910194174757281 0.9753014938956188 0.1960965459818884 1.3866235282600423 0.7031088807706056 1.4929387846379636 0.2609606457365817 2.7528489700449297e-05 2.8841975049086312e-05 0.0002296483500821 0.0002022933287296 1.6091572544199994e-05 +Abnormality of the vasculature of the eye 20 66 2.29252697430393 0.0218752528458283 16.27912621359223 72.06553398058253 0.403343228775578 0.4479390001832676 5.629952078086087 5.671259209870798 1.3806507490937323 0.3789287537753926 0.0004775065194044 0.0045822960973511 0.0003340193374231 0.0001325499765005 0.0035083250188987 +Aganglionic megacolon 4 10 2.2798526406865944 0.0226164297039519 4.577669902912621 18.25728155339806 0.4558371355095859 0.5167976183070249 2.4238472202980517 4.014756807292137 0.8563808019734481 0.3054816181108372 0.442569177969815 0.3926779415133941 0.2605001929873321 0.4571321408868149 0.563015324112921 +Perseveration 2 9 2.271739040039811 0.0231022767148496 2.228155339805826 7.747572815533981 0.2549642857282638 0.5145676770156781 1.6269524477167985 1.327223882767772 0.9406545169811942 0.3029494680332692 0.0017552448339215 0.0786913117950012 0.1515272625734178 0.0074273483269255 0.046330877355434 +Abnormal delivery 4 19 2.2616872528972523 0.0237167328518514 5.699029126213592 21.5873786407767 0.8953606264352741 0.420193574632847 2.851791981194637 2.0047603353673553 0.8292150006712276 0.3226752218541708 0.0062777451714846 1.0 0.08610744549237 0.0075944976014186 0.099423410284734 +Xerostomia 6 15 2.259914340804172 0.0238265676924325 4.225728155339806 15.218446601941748 0.9400183964262208 0.3676147626670514 2.1144482637513415 1.4041718405623504 0.8665256443899695 0.3037909474394171 0.1002989319267731 1.0 1.0 0.0118572988629309 0.0017414168435746 +Corneal opacity 13 50 2.256114687082541 0.0240634495572076 15.480582524271844 53.95631067961165 0.9517965339960472 0.3644495779961974 5.277458167452316 6.791845051563607 1.5225460520633525 0.3686110256368129 0.0004207072715614 0.2301287074237091 0.0004556496425242 0.00019906057211 0.0020229970424072 +Decreased absent ankle reflexes 6 13 2.2516257372182262 0.0243459332082374 4.54126213592233 13.740291262135925 0.614698131143983 0.4646843865398717 2.302541095049457 2.6371188884218366 0.9410514279256472 0.3107404522460847 0.336322941724431 1.0 1.0 0.1467432355955838 0.0002922281845516 +Elevated hepatic transaminase 20 82 2.239991925547892 0.0250914470743544 20.796116504854368 97.83009708737865 0.4637455337618785 0.5905786696631136 8.065098273498217 9.77490679767308 0.8877652953064216 0.359438953659048 0.0026040475112899 1.0 0.3045959264313371 2.931534330065328e-05 0.0001081662163695 +Platyspondyly 7 28 2.2296697600904154 0.0257693748662555 8.28640776699029 33.730582524271846 0.6662607465302498 0.4948187493576657 3.3732974430890796 4.074278380383408 0.9978722835718216 0.3450714604006198 0.119556278594864 0.3306605597140526 0.1897338295109766 0.0008718254497284 0.018640278593319 +Poor motor coordination 6 10 2.226575411710296 0.0259756637889585 3.2864077669902914 13.24514563106796 0.2556901127076379 0.5478308001007333 2.2132675200434946 1.739211049838107 0.8192172394208537 0.2874561274382535 0.1238525752506518 0.1835089509173778 0.3339976348230559 0.2707185745648809 0.0509303706641057 +Delusions 7 17 2.224654864083956 0.02610441649155 5.912621359223301 18.439320388349515 1.0629964764413025 0.2985925736346436 2.390745896997379 2.2281751696560335 1.2165016471530676 0.297036724651636 0.0912731207748974 0.0121686135974036 0.0443091130960601 0.0097601039903573 0.0002117782770131 +Frontotemporal dementia 3 10 2.224103275780282 0.0261414965573545 3.4344660194174756 10.344660194174756 0.5931524822816645 0.4529040772840182 1.8896952177098856 1.3751065734754873 0.9402199282689112 0.308701646569884 0.006100642539648 0.1178616319260966 0.2223047329091382 0.0242110622206542 0.0349002560689848 +Diffuse cerebral atrophy 6 13 2.2194372378115577 0.0264569926417315 4.320388349514563 16.526699029126213 0.5483679808262946 0.4347204443631116 2.152955035100649 2.40585163991881 0.9855175878314706 0.3059596216572743 0.0139683468541165 0.0121686135974036 0.0443091130960601 0.0097601039903573 0.0012367549633919 +Abnormal sella turcica morphology 2 5 2.219435097336297 0.0264571381224216 2.1310679611650487 7.259708737864078 0.3527899633564624 0.3302362894597835 1.2627239108344035 1.5017879029535528 1.2692310088213898 0.2695913026312082 0.231577113144496 0.083126337411673 0.1596960736798767 0.0087554356838108 0.053660443290246 +Macular degeneration 4 11 2.2182209540614592 0.0265397706969869 3.5072815533980584 13.201456310679612 0.7081764422831481 0.3007939344006393 1.5711122114355351 1.3240485924903622 1.388921785741595 0.3097317018961461 0.1741776842229999 0.2220822570468345 0.3955810682553247 0.0367529115341812 0.105877285302659 +Abnormality of glycolipid metabolism 4 8 2.21719311989692 0.0266098975426671 3.83495145631068 7.228155339805825 0.3163887308740252 0.1681411938672545 1.311614193945771 0.5964160722258837 1.870431483654663 0.2292796295173983 8.364969714787759e-06 1.2225095413484733e-05 1.612359251599596e-06 1.828578586842436e-06 6.353096176512488e-08 +Focal t2 hyperintense brainstem lesion 4 12 2.206928684541419 0.0273190420624098 5.745145631067961 17.558252427184467 0.7787968952644161 0.3563659539921697 2.720936576360794 2.4403574571781053 1.1656572167307155 0.3009968442621839 1.0 1.0 1.0 0.0383377547470353 0.0156507911863037 +Abnormal lactate dehydrogenase level 4 17 2.206826253821912 0.0273262001384104 4.143203883495145 17.87621359223301 -0.1889046507521062 0.4455642582293665 2.002759607594022 2.089436499733168 1.1284322896017482 0.2992123479577444 0.0050542988446585 1.0 0.0775813155228076 0.005869339632186 0.0813065502215209 +Abnormality of skull ossification 4 12 2.201343168549841 0.0277117390016505 4.366504854368932 12.970873786407768 1.1881205011944458 0.2637442069575459 1.99249670608582 1.4511884027191762 0.8848235988748787 0.2626440236811827 0.086855705123509 1.0 0.0420348553288257 0.0012549484261259 0.0227729863487681 +Abnormal larynx physiology 5 14 2.196497226439821 0.0280563734681329 3.7694174757281553 14.78640776699029 0.7777362681295714 0.3936810823701626 2.010346212391085 1.51625807571557 0.9784109402665334 0.3028779878197117 0.0150791132147506 1.0 1.0 0.0107757845080475 0.007075120136557 +Abnormality of alkaline phosphatase level 12 20 2.181956835172042 0.0291127185808204 5.424757281553398 21.550970873786408 0.2837846270756372 0.4096308965627429 3.0903339262997473 2.8582743162812116 1.1598915940568888 0.2934678757183479 0.1689977859538334 1.0 1.0 0.0075944976014186 0.0029027937196318 +Beaking of vertebral bodies 2 8 2.175378070082474 0.029601796489622 2.907766990291262 9.131067961165048 0.3586161575708288 0.4129848752927794 1.656478269216378 1.797329687366794 1.1037549452259698 0.2913355105961067 0.0335158853547684 0.0919337377678228 0.0155240337321844 0.01180448121602 0.0698565063333662 +Diminished motivation 6 21 2.173959575461053 0.0297081712333913 6.317961165048544 24.803398058252423 -0.1022353224236823 0.6108539410275737 2.662827119874009 2.347832734733778 0.8069717348682304 0.2991361798929995 0.0092823236717934 0.2406936845278361 0.1039407380726692 0.000423196822916 0.0058484491569579 +Disproportionate short limb short stature 7 16 2.173815804450184 0.0297189711308321 6.587378640776699 19.902912621359224 1.344701363676014 0.2682000023842777 2.8599402401133336 3.1206003999939886 0.9439707190715964 0.2973700803613334 0.2594015473742934 1.0 0.1388614812827933 0.0242455864981032 0.016498993555687 +Ovoid vertebral bodies 2 6 2.171957054561644 0.0298589023350126 2.6237864077669903 7.359223300970874 0.2693483252678329 0.2925663833748981 1.3659227234427256 1.183251804829311 1.455225024558189 0.2873440473038876 0.0032903114147814 0.0044823878286489 0.0010099703116007 0.0135296171343662 0.0786846017539525 +Abnormal circulating cholesterol concentration 9 28 2.144626112830933 0.0319827527527363 9.691747572815531 31.70873786407767 0.976903841313624 0.2790879029908041 4.4525142732793395 3.04459115485426 1.5883623188049951 0.3063455707490317 0.0007467590972521 0.0502821167245636 0.005792379744814 1.2063424072896e-05 1.1995040614350703e-05 +Saccadic smooth pursuit 2 5 2.138850460863773 0.0324477812146566 1.422330097087379 4.543689320388349 0.8362156135090372 0.3642207174662807 0.9534232690001144 0.8392865558887826 0.9637903368044616 0.2907282500472056 0.0146989510868729 1.0 0.1180585699575878 0.0382400085743442 0.0224777557227792 +Confusion 9 15 2.1280646690579363 0.033331722150262 4.924757281553398 17.62378640776699 0.5770193034786405 0.489615172337713 2.480343831732211 2.1535063377225914 0.8853427180085949 0.3168581188371634 0.1485717214563564 0.2030241760545403 0.3655284832956332 0.0265672828357611 0.007013421835749 +Abnormality of the peripheral nervous system 23 80 2.1275941379350902 0.0333707486852856 21.851941747572816 100.3252427184466 0.4924736649059071 0.6070149484118681 7.60428603700104 12.016414489110195 0.8367540963076672 0.3602458415795309 0.0107473320613836 0.1683180531734008 0.3151803399121733 0.0126224998164626 0.0089077216190019 +Coxa valga 4 17 2.127375068934599 0.0333889319206619 5.245145631067961 19.95145631067961 0.3761170106319844 0.4485543113651226 2.6522752145550523 3.395824508532713 1.0354006500412785 0.2987185055269495 0.0138154491969391 0.2660187864050092 0.0235138787886837 0.0191561107000251 0.0344196216171049 +Eeg with spike wave complexes 2 10 2.127070582781745 0.0334142190563764 3.3567961165048543 13.82766990291262 0.3069722257003373 0.4002472963954175 2.1227792341357876 2.102220603041329 1.0976485702648275 0.2780557299464236 0.028877175146641 0.0204708743585679 0.0720571885403784 0.0998367022916053 0.3865751636037191 +Cerebral inclusion bodies 4 12 2.1236876244533303 0.0336962729058443 3.844660194174758 13.655339805825244 0.5051551663301821 0.4226246963159299 1.8115448621120656 1.6612796655742368 1.090041660052819 0.3107400387490911 0.0118914584472129 0.0108643857486399 0.0398064357050217 0.007920049564759 0.0202035082798241 +Abnormality of femur morphology 19 57 2.1212603773156395 0.033899896791532 17.20873786407767 66.68203883495146 0.8363246416857221 0.4265359075043799 5.791282481104246 7.777760660479065 1.2398669594969238 0.3848538433547022 0.0234557389728515 0.0668873192346767 0.0396084623553153 0.0009115986749252 0.0012207923406636 +Abnormal upper motor neuron morphology 2 9 2.1089245440226896 0.0349510952643168 2.104368932038835 10.152912621359222 0.6668580581129538 0.4264480473015415 1.810508789672501 1.2708136152843803 0.93546763978058 0.305632736845798 0.0275018892804849 1.0 1.0 0.0087554356838108 0.053660443290246 +Abnormality of the spleen 26 103 2.104974181142277 0.0352935555845015 25.813106796116504 118.70145631067962 0.3588217969137363 0.458825127767632 7.787937091054707 11.816587724549532 1.4144879662363967 0.3705037351683085 4.509258994589445e-05 0.0253940315541129 0.000503366064418 1.25108914490694e-05 0.0001739419056109 +Aplasia hypoplasia involving the skeletal musculature 2 9 2.1015181076124554 0.035595510157347 2.4101941747572817 9.259708737864075 0.5828831505506118 0.4604979976196062 1.3984016400026793 1.3175543365377669 0.8139971763281372 0.2755610854392571 0.0162384338019031 1.0 0.3009165941166509 0.0596874537258691 0.2658311710333132 +Osteolysis 8 27 2.093743247629516 0.0362828581540495 5.286407766990291 27.73543689320388 0.5057473150905948 0.5186942536500823 2.7835351045722914 3.2828484188526224 0.8911453392732208 0.3083503296551068 0.0018641413197488 0.2552681350600493 0.0207328276809773 0.0001028265848382 0.0025023010526467 +Cognitive impairment 46 147 2.093541019876473 0.0363008863056431 40.38834951456311 166.01456310679612 0.9678903819313606 0.4602309002251459 12.35477425089026 15.27402711863426 1.6121748345734526 0.4202585511538368 7.456543653838427e-06 4.4246932363971297e-05 0.0012182170999661 1.3513587088112382e-06 2.6167751459956125e-08 +Osteoarthritis 5 10 2.091215680572725 0.0365087343117385 3.783980582524272 10.466019417475728 1.011181157871384 0.2141266987491498 1.7388858389175554 1.4384831140913243 1.3548711699904423 0.2434324139099127 0.0618715167696397 0.1263420182810564 0.0293903981750984 0.0043549454623746 0.0018986041281287 +Aplasia hypoplasia involving the vertebral column 6 14 2.087135721531822 0.0368758678529757 4.679611650485437 14.847087378640778 0.8883735186508074 0.3527358077962234 2.3127489306396716 2.051146083169333 0.9597872998017484 0.2871451112966173 0.1287125856875722 0.187449079081247 0.0640285846884502 0.0036383017284534 0.0042432632735376 +Micromelia 7 20 2.0852294901459856 0.0370484742253622 5.094660194174757 22.143203883495147 0.8629445430209934 0.441515711810184 2.300964472974588 2.4557002100293746 0.9703688762337884 0.333324080713348 0.084014791731071 1.0 0.1487873266068847 0.0015979936813088 0.0209555118054096 +Hallucinations 13 40 2.081583448971828 0.0373805344948843 11.20388349514563 45.44660194174757 0.6705549628539956 0.4221278622600144 3.902598644570227 4.462852401771342 1.2595119979903464 0.3693437289960082 0.0006113004702296 0.0001111606586658 0.0027125023591425 2.85318783748576e-05 5.382001706156264e-06 +Abnormal thoracic spine morphology 8 24 2.0795319999666195 0.0375684797384696 6.558252427184466 27.104368932038835 0.8238927765093872 0.4398474942511601 2.7009535990178555 2.5649391710658156 0.8855000478727516 0.3360788168488923 0.5971936063350395 1.0 0.4515227909961177 0.0037630129831157 0.0028047706339862 +Progressive psychomotor deterioration 5 9 2.076284733376992 0.0378676244337357 3.349514563106796 8.320388349514563 0.5379615244672443 0.2176134167318772 1.5053866894387542 0.6226094824456632 1.5848775742530583 0.2457660654605461 0.0005989298062784 0.0014481500629001 0.0056684159955205 0.00262770885776 9.033677057044543e-06 +Hammertoe 6 13 2.061562953363335 0.0392493641466173 3.662621359223301 18.046116504854368 0.6966488433366873 0.4834332623162832 2.346296590711119 2.471254047837027 0.8432277041521599 0.3207676556555462 0.1142744618752262 1.0 0.3209553841799009 0.0720513532108381 0.0118494727859131 +Subcutaneous nodule 6 16 2.0578757299707964 0.0396020640582048 5.174757281553398 17.716019417475728 0.7715929851765809 0.3892857335439222 2.3624373807533945 1.5246949972287631 1.0645096840549642 0.3076166958299045 0.0076835968325849 0.2295798469686227 0.4072036678679048 0.0018561414510811 0.0041787730332236 +Slurred speech 3 9 2.0433949069681865 0.0410133612400109 2.45873786407767 8.864077669902912 0.5323927403653204 0.4147809462031548 1.4075891250208603 1.616351781434359 0.9973486618272436 0.2852319096618858 0.0618715167696397 0.1263420182810564 0.2372212797486779 0.0043549454623746 0.0101939997718642 +Global brain atrophy 4 19 2.0338355435724 0.0419681795383084 4.944174757281553 20.466019417475728 0.5470181350831151 0.5081828354508747 2.583421763532785 2.0184370286085005 0.920761985531802 0.3339660659374047 0.0272765651043488 0.1952735388158895 0.3530974878629287 0.0044406378118471 0.0205399046658008 +Motor neuron atrophy 7 21 2.0328580367676405 0.0420668676451212 5.410194174757281 22.424757281553397 0.8356342611289532 0.3959768073616548 2.754377444710008 1.6813276911909307 0.954775311801755 0.3176984078794489 0.0357664341387132 1.0 1.0 0.006984722202598 0.0005793873081042 +Unusual infection by anatomical site 4 10 2.032708734206081 0.0420819583557692 3.907766990291262 13.49271844660194 0.7293808434681487 0.4605880442375236 1.9820157102817233 2.372464489866843 0.7897149485111757 0.3081613942392058 0.497818985601299 1.0 1.0 0.0265672828357611 0.0756938725025209 +Multiple prenatal fractures 2 5 2.032393270386505 0.0421138588298393 2.133495145631068 6.592233009708738 0.8339635044673502 0.3927176527212103 1.278707029562348 0.9747978949493776 0.8175122325077913 0.2896660614910132 1.0 1.0 1.0 0.003355333516566 0.0224777557227792 +Fatigable weakness of bulbar muscles 7 15 2.032102304608032 0.0421433001396585 4.063106796116505 15.25242718446602 0.7188062683419271 0.4547422847838221 2.248170358195387 1.4859761696395852 0.8778510505210118 0.3261836450387849 0.1238525752506518 1.0 1.0 0.0808776862517318 0.0509303706641057 +Nephrotic syndrome 6 22 2.027243395854665 0.0426375271426924 6.691747572815534 26.449029126213592 0.5692557086068671 0.4287880468715059 3.1782986616871702 3.4415823902191023 1.075640445131052 0.3251004953320756 0.417655425097901 0.080392228927645 0.2426635790855314 0.0315426209963371 0.102131488895314 +Hypopigmented skin patches 2 17 2.026213280420013 0.0427429333001048 6.461165048543689 25.37135922330097 0.4666867513080546 0.4923758628930654 3.0339417473242687 3.9530564673509807 1.0171256647501936 0.3356931601315818 0.1561437002004172 0.0748187401998431 0.061711249787699 0.3991096001531553 0.4812222348210965 +Neuronal loss in central nervous system 3 11 2.01594824297549 0.0438053881921565 4.087378640776699 12.526699029126211 0.982175765643533 0.2959736314179056 1.731247914675439 1.993135251988059 1.1236470294677874 0.2967990988512021 0.0091327046021892 0.134742527043449 0.2518545844225215 0.0056128198685199 0.0136556200878641 +Fatigue 18 65 2.000779368921929 0.0454161716980165 16.91504854368932 80.75 0.4479867994971399 0.6200877637843074 6.007282534078571 7.6753371893926445 0.7480205814873203 0.3310366012861978 0.4457465526616008 0.312340377108489 0.6644003935793442 0.0278691046926699 0.0101852274930356 +Hyperintensity of cerebral white matter on mri 3 19 1.9960580332950235 0.0459276063326699 5.844660194174757 19.76456310679612 0.5239793769920946 0.3497882694217939 2.383223245915457 2.1845455756818453 1.3844482033830876 0.3203944687906004 0.0272765651043488 0.0196403757049561 0.0091243340822671 0.0230341265569123 0.0205399046658008 +Paresthesia 8 21 1.9956762906572845 0.0459691694204211 5.66747572815534 23.635922330097088 0.7476018604198311 0.4719429115693522 2.535880467324221 3.039141242047335 0.8424234714329004 0.3217041155902614 0.0234060243887033 0.0502821167245636 0.0353550186833354 0.0350926445127817 0.009987232196926 +Breech presentation 2 7 1.993753065727233 0.0461790470175162 2.638349514563106 8.21116504854369 0.7736222439518552 0.4196808204976839 1.3944359593863973 0.9861032468943997 0.7960847313421169 0.2920425637888471 0.0366975247182733 1.0 0.1837383274168749 0.0135296171343662 0.0786846017539525 +Hypohidrosis 1 8 1.9823597711762095 0.0474389887036528 3.094660194174758 9.514563106796116 -0.4756466337815434 0.4523993517066125 1.8560503610582415 1.4455427150946332 0.9891348536021548 0.3071923224725194 0.0957551212184567 0.1594721229818057 0.2941077913158182 0.2166326226637888 0.5263813343809725 +Glomerulopathy 3 10 1.976677589266396 0.0480780855792728 2.820388349514563 9.96359223300971 0.665958332940798 0.3017859836474246 1.512655943869742 0.8764085521210618 1.2285906000166364 0.2785070215881056 0.0433903927851653 0.0053672672920639 0.0202898922491691 0.0173886328284286 0.0231565450655555 +Cerebral calcification 5 28 1.9712632064692237 0.0486937775508573 6.839805825242719 32.237864077669904 0.1872119254892361 0.6247506692757506 3.5857820586316875 4.17769427057777 0.7714290497698931 0.304252090591211 0.0112648701047645 0.0734458650364987 0.001973739432479 0.0252029938936908 0.0810035356123481 +Aspiration 1 7 1.968374739276829 0.0490249361833488 2.6699029126213594 9.79126213592233 -0.0172085582186148 0.5174459915750989 2.0521754950341604 1.2464011724725987 1.0157484074741647 0.3174080591477043 0.231577113144496 0.083126337411673 0.0126574737404708 0.0693365470158766 0.2160114460330814 +Cachexia 5 16 1.962458895745233 0.0497090816488532 4.371359223300971 18.25485436893204 0.1308736058795594 0.3437329688633732 1.963367203014057 1.8448565940413904 1.2969303512721055 0.2680999243445657 0.0305266349759202 0.2030241760545403 0.3655284832956332 0.0008884443610078 0.007013421835749 diff --git a/msigdb_hp/metrics.json b/msigdb_hp/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..c85af0acb937793d591673a85ed67ae9f86661b5 --- /dev/null +++ b/msigdb_hp/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2644, + "annotations_size": 4491, + "title": "Average number of proteins per term", + "value": 20.039189490091292 +} \ No newline at end of file diff --git a/msigdb_hp/paths.json b/msigdb_hp/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..87bdbc4ca743270fca62417770ada13f3bb92a59 --- /dev/null +++ b/msigdb_hp/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/msigdb_hp/fragment/C197/C197_val_log2fc"} \ No newline at end of file diff --git a/msigdb_hp/result.tsv b/msigdb_hp/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..89b26029e1f5a79e36030942c17f2c4e538c09f9 --- /dev/null +++ b/msigdb_hp/result.tsv @@ -0,0 +1,1499 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Mental deterioration 0.6078978205453793 3.3975121454132258 0.0006800156933344 0.9528767758087614 0.8211407869220101 89 Q13510,O75503,P50897,Q9BQE5,P07602,P05067,Q13501,P35637,Q14108,P22626,Q06787,P06865,Q10713,P16278,P21964,P61916,P10644,O00429,P54802,O00592,Q5XKP0,P35670,O95470,P04062,O43681,Q9H2C2,Q9NPL8,P17900,Q9Y487,O75306,P07686,O15118,Q9NQZ5,Q03164,O95140 35 +Splenomegaly 0.5549370485360166 3.0615882863727126 0.0022016605364052 0.9999497529190984 0.8211407869220101 76 Q13510,P07602,P15586,Q14108,Q9NZ08,P14174,Q10713,P01889,P16278,P51798,P21964,P61916,Q14739,P36551,P54802,P35670,P04062,Q15392,Q16625,P04066,P28070,Q96A33,P38571,P10253,P08236,O15118,O00754,Q15904,Q9NZJ7 29 +Clumsiness 0.7570442453887305 2.859686962259373 0.0042405937140641 0.9999999948537672 0.8211407869220101 18 Q13510,O75503,O43681,Q15067,P07602,Q13501,Q9NR77,P35670,O14773,O00754 10 +Abnormality of the upper respiratory tract 0.5357278070980576 2.8513876027603233 0.0043528872405629 0.9999999968988332 0.8211407869220101 78 Q13510,P16278,P01889,P08236,P07602,Q13501,Q14739,P15586,P54802,P04066,P28070,P35637,Q9UBM7,O00754,Q9UHX1,Q06787 16 +Supranuclear gaze palsy 0.7725080229374353 2.810915141481126 0.0049400813086095 0.999999999780767 0.8211407869220101 16 P61916,P07602,Q13501,Q99720,O15118,P35637 6 +Cherry red spot of the macula 0.8936814783670981 2.7279753242994045 0.0063724374725842 0.9999999999996602 0.8211407869220101 9 P16278,P10619,P07602,P07686,P17900,P06865 6 +Abnormality of corneal stroma 0.8090108849228976 2.7004176956760855 0.0069252469546341 0.999999999999972 0.8211407869220101 11 Q13510,P16278,P10619,O75845,Q16625,O43505 6 +Dysostosis multiplex 0.9548729616988988 2.64432749451968 0.0081853417514221 1.0 0.8211407869220101 7 P16278,P10619,P08236,P15586,P04066,P54802 6 +Abnormal tissue metabolite concentration 0.7737758573396467 2.6359420051198477 0.0083904070441243 1.0 0.8211407869220101 13 P17900,P06280,P07602,P06865 4 +Pathologic fracture 0.7474734081409359 2.616151873236898 0.0088926993837046 1.0 0.8211407869220101 15 P04062,Q14108,Q13126,O15269,P35670,O75845,P22626 7 +Ascites 0.7013764077213532 2.5812148204110317 0.0098453296576324 1.0 0.8211407869220101 25 Q13510,P38571,P04062,O75787,P61916,P08236,Q14739,Q01844,O15118,Q14108 10 +Abnormal morphology of the conjunctival vasculature 0.9330992807154352 2.5562372958339066 0.0105810934024825 1.0 0.8211407869220101 7 P10619,O00462,P06280 3 +Abnormality of extrapyramidal motor function 0.5615897530257605 2.545692870827159 0.0109061096901581 1.0 0.8211407869220101 64 P12235,P07602,P05067,Q13501,P35637,Q6DKK2,Q06787,P06865,P16278,O75787,O00592,P04062,P35270,Q9Y4P3,P17900,Q9H6K4,O14949,Q99720,P07686,O75569,Q9NZJ7 21 +Abnormal form of the vertebral bodies 0.4988841314473046 2.5251751589080205 0.0115640635637541 1.0 0.8211407869220101 75 P15586,O75874,Q9Y619,Q10713,P16278,P10644,O75845,Q14739,P54802,Q9UHX1,Q9UBM7,Q32P28,Q9Y4P3,P04066,Q8TAA9,P08236,Q9BV10,P16435,O00754,P48735 20 +Exaggerated startle response 0.9210731746203358 2.5071683266152007 0.012170273943401 1.0 0.8211407869220101 7 P16278,P17900,P06865 3 +Abnormal urine carbohydrate level 0.7559061928330879 2.488508361660415 0.0128280220590655 1.0 0.8211407869220101 12 O00462,P10253,P04066,P16278 4 +Disproportionate short stature 0.6886478914197 2.482139409753441 0.0130596170662951 1.0 0.8211407869220101 20 P16278,P10644,Q32P28,Q15392,Q14739,Q9BV10,Q9UHX1,Q9UBM7,O75718 9 +Abnormal circulating lipid concentration 0.5536032860458046 2.4762875425405775 0.0132756611183162 1.0 0.8211407869220101 64 Q16836,P06280,P07602,P61916,O75845,Q14739,O75844,Q9UBM7,O95470,P50402,Q15392,Q9Y4P3,O43772,P28070,P38571,P23786,Q8N511,Q9BV10,Q15904 19 +Oligosacchariduria 0.9471548360871032 2.4617416018784892 0.0138264239784473 1.0 0.8211407869220101 6 O00462,P10253,P04066,P16278 4 +Abnormal conjunctiva morphology 0.6818614213805695 2.4592848886035545 0.013921409727639 1.0 0.8211407869220101 24 Q13510,P01889,P10619,O00462,P02786,P06280,P04066,P28070 8 +Loss of speech 0.6818400207972881 2.4456710428065773 0.01445828506044 1.0 0.8211407869220101 21 P50897,P61916,P07602,O15118,O00754,P17900 6 +Arteriosclerosis 0.7354609661444154 2.437198148082936 0.0148015661226337 1.0 0.8211407869220101 13 Q13510,P16278,P61916,O75845,O75844,O15118 6 +Abnormal lower motor neuron morphology 0.822389189358997 2.408687646999633 0.0160099936294255 1.0 0.8211407869220101 9 Q13510,Q99720,Q13501 3 +Progressive neurologic deterioration 0.6751354940297661 2.4063839168992622 0.0161113234055705 1.0 0.8211407869220101 21 P04062,Q10713,P16278,O43681,P07602,P07686,Q9NPL8,P54802,Q5XKP0 9 +Urinary glycosaminoglycan excretion 0.9304593152940136 2.395827215946801 0.0165829053597852 1.0 0.8211407869220101 6 P15586,P54802,P04066,P16278 4 +Mucosal telangiectasiae 0.8885576810686402 2.373002425929524 0.0176441480357252 1.0 0.8211407869220101 7 P10619,P06280,Q8IZA0 3 +Increased cerebral lipofuscin 0.9338218765591634 2.365405072320018 0.0180103598141914 1.0 0.8211407869220101 5 P50897,O75503,P07602 3 +Areflexia of lower limbs 0.6655778206542836 2.350045891622309 0.018771096584436 1.0 0.8211407869220101 21 P12235,Q9H6K4,O75787,Q16637,O75477,Q15041,Q15067,Q13501,Q9NR77,O95140 10 +Angiokeratoma 0.9689393939393948 2.3476518588131894 0.0188921702053064 1.0 0.8211407869220101 4 O00462,P06280,P16278 3 +Severe short stature 0.6651006244160627 2.3420265768798645 0.0191793491283618 1.0 0.8211407869220101 18 P10619,P16278,Q15392 3 +Foam cells 0.9166034874905196 2.340723968107388 0.0192463907846334 1.0 0.8211407869220101 6 Q13510,P16278,P61916,O75845,O15118 5 +Limb ataxia 0.6632911117967606 2.33962465100773 0.0193031288550142 1.0 0.8211407869220101 22 P04062,Q8IV08,Q13501,Q9NR77,Q14108,O14773,O00754 7 +Amyotrophic lateral sclerosis 0.6957671605036435 2.336280919761098 0.0194766052809658 1.0 0.8211407869220101 15 P22626,P50995,Q13501,Q99720,P35637,Q92804 6 +Dementia 0.584743285202358 2.3313824313989775 0.0197332030832089 1.0 0.8211407869220101 54 Q13510,Q06787,P04062,Q14108,Q9Y487,P61916,P22626,O00429,P35670,P07602,P05067,Q13501,O15118,Q9NQZ5,O00592,P35637,P17900,P06865 18 +Ectopic calcification 0.5965928189477255 2.329217818027148 0.0198475294494548 1.0 0.8211407869220101 51 P38571,P04062,P23786,O00584,P10644,P08236,O00429,O75845,P05067,Q14739,Q16625,O75844,P53634,Q9UBM7 14 +Abnormal vertebral morphology 0.5038443675052208 2.308658986610838 0.020962511917119 1.0 0.8211407869220101 96 P15586,O75874,Q9Y619,Q14108,Q10713,P16278,P10644,O75845,Q14739,P54802,Q9UHX1,Q9UBM7,P04062,P10619,Q32P28,Q9Y4P3,P04066,O75718,Q8TAA9,P08236,Q8NCH0,Q9BV10,P16435,O00754,P48735 25 +Rhizomelia 0.7293918198551521 2.299349357676447 0.0214851091750516 1.0 0.8211407869220101 11 O15228,Q15392,Q14739,Q9BV10,Q03164,Q9UBM7,O75718 7 +Increased circulating lactate dehydrogenase concentration 0.709405092926862 2.2991788062832472 0.0214947879725762 1.0 0.8211407869220101 13 P23786,P10253,Q5JRX3 3 +Abnormal macrophage morphology 0.9162561576354696 2.295617332993574 0.021697770833549 1.0 0.8211407869220101 5 Q13510,P61916,O15118,P16278 4 +Psychomotor deterioration 0.7975106264978016 2.2942307071413035 0.021777250362492 1.0 0.8211407869220101 9 P50897,P07602,P06865 3 +Abnormality of the vasculature of the eye 0.5220392791964032 2.29252697430393 0.0218752528458283 1.0 0.8211407869220101 66 Q13510,P06280,P07602,Q9NZ08,P06865,P01889,P16278,P21964,O00462,P04439,Q14739,P10619,Q9Y4P3,P04066,P28070,P17900,Q15555,P02786,O75306,P07686 20 +Thickened ribs 0.95378787878788 2.288229147802153 0.0221241801226912 1.0 0.8211407869220101 4 P15586,P16278,P54802 3 +Aganglionic megacolon 0.7605805389260093 2.2798526406865944 0.0226164297039519 1.0 0.8211407869220101 10 Q96EK5,Q9UBM7,Q10713,P42892 4 +Perseveration 0.7926623241595496 2.271739040039811 0.0231022767148496 1.0 0.8211407869220101 9 Q13501,P61916 2 +Abnormal delivery 0.651263325013199 2.2616872528972523 0.0237167328518514 1.0 0.8211407869220101 19 Q9Y619,Q9UBM7,O75844,Q9Y487 4 +Xerostomia 0.6819679127020217 2.259914340804172 0.0238265676924325 1.0 0.8211407869220101 15 P55011,P50995,Q13501,Q14739,P35637,Q92804 6 +Corneal opacity 0.5907069060151906 2.256114687082541 0.0240634495572076 1.0 0.8211407869220101 50 Q13510,P16278,P10619,P08236,P06280,O75845,Q06136,Q16625,O75844,P04066,Q9UBM7,O00754,O43505 13 +Decreased absent ankle reflexes 0.7005296923584297 2.2516257372182262 0.0243459332082374 1.0 0.8211407869220101 13 P12235,Q9H6K4,O75787,Q15041,Q13501,O95140 6 +Elevated hepatic transaminase 0.4800118740374208 2.239991925547892 0.0250914470743544 1.0 0.8211407869220101 82 Q13510,Q16836,Q9Y619,Q10713,P01889,O75787,O75845,Q14739,Q02241,Q5XKP0,Q16625,O43772,P28070,P23786,P38571,P10253,Q8N511,Q15067,Q07021,Q15904 20 +Platyspondyly 0.6400572392798135 2.2296697600904154 0.0257693748662555 1.0 0.8211407869220101 28 P16278,P08236,Q14739,O75874,P04066,O00754,P48735 7 +Poor motor coordination 0.7497274584512735 2.226575411710296 0.0259756637889585 1.0 0.8211407869220101 10 Q10713,O75503,O95140,Q9Y5P6,P35670,Q06787 6 +Delusions 0.655360405711849 2.224654864083956 0.02610441649155 1.0 0.8211407869220101 17 P04062,P21964,Q9BQE5,O43681,P07602,Q9NZJ7,O00754 7 +Frontotemporal dementia 0.7492255480149336 2.224103275780282 0.0261414965573545 1.0 0.8211407869220101 10 Q13501,P35637,P05067 3 +Diffuse cerebral atrophy 0.6945510528903093 2.2194372378115577 0.0264569926417315 1.0 0.8211407869220101 13 Q10713,P16278,O75787,O00429,P07602,Q06787 6 +Abnormal sella turcica morphology 0.8972378520034938 2.219435097336297 0.0264571381224216 1.0 0.8211407869220101 5 P08236,P16278 2 +Macular degeneration 0.7137598127182724 2.2182209540614592 0.0265397706969869 1.0 0.8211407869220101 11 Q13510,P04062,P50897,P04439 4 +Abnormality of glycolipid metabolism 0.8164791868322916 2.21719311989692 0.0266098975426671 1.0 0.8211407869220101 8 P17900,P06280,P07602,P06865 4 +Focal t2 hyperintense brainstem lesion 0.7019655510132516 2.206928684541419 0.0273190420624098 1.0 0.8211407869220101 12 O96000,Q96CU9,O43676,O75306 4 +Abnormal lactate dehydrogenase level 0.6522857118572618 2.206826253821912 0.0273262001384104 1.0 0.8211407869220101 17 P23786,P10253,Q5JRX3,O43505 4 +Abnormality of skull ossification 0.7009142085773249 2.201343168549841 0.0277117390016505 1.0 0.8211407869220101 12 Q14739,O75844,P54802,Q32P28 4 +Abnormal larynx physiology 0.6805055154259035 2.1964972264398215 0.0280563734681329 1.0 0.8211407869220101 14 Q13510,P50995,Q13501,P35637,Q92804 5 +Abnormality of alkaline phosphatase level 0.6377015661711143 2.181956835172042 0.0291127185808204 1.0 0.8211407869220101 20 P38571,P51798,Q01130,Q8N511,P22626,Q96AY3,O75845,Q96A33,Q13501,Q969N2,Q14739,P09651 12 +Beaking of vertebral bodies 0.807097344464715 2.175378070082474 0.029601796489622 1.0 0.8211407869220101 8 P04066,P16278 2 +Diminished motivation 0.6361270682746666 2.1739595754610535 0.0297081712333913 1.0 0.8211407869220101 21 Q06787,Q13501,O00592,P35637,P17900,P06865 6 +Disproportionate short limb short stature 0.6566370207630103 2.1738158044501836 0.0297189711308321 1.0 0.8211407869220101 16 P10644,Q32P28,Q15392,Q14739,Q9BV10,Q9UBM7,O75718 7 +Ovoid vertebral bodies 0.8747242342158461 2.171957054561644 0.0298589023350126 1.0 0.8211407869220101 6 P15586,P16278 2 +Abnormal circulating cholesterol concentration 0.6265851958002694 2.144626112830933 0.0319827527527363 1.0 0.8211407869220101 28 P50402,Q8N511,P61916,O75845,P07602,Q15392,Q14739,Q9UBM7,Q15904 9 +Neurofibrillary tangles 0.9169971018940244 2.1424239208438274 0.0321593846915697 1.0 0.8211407869220101 4 P61916,P05067 2 +Saccadic smooth pursuit 0.8772935854993222 2.1388504608637735 0.0324477812146566 1.0 0.8211407869220101 5 O14773,Q06787 2 +Confusion 0.6584434927617098 2.1280646690579363 0.033331722150262 1.0 0.8211407869220101 15 Q16836,P01889,P05067,P40939,P36551,Q9Y619,P18074,O00754,Q9NZ08 9 +Abnormality of the peripheral nervous system 0.466733949835926 2.1275941379350902 0.0333707486852856 1.0 0.8211407869220101 80 O95831,O15270,P06280,P07602,P42892,Q9Y619,P07196,Q06787,Q10713,P21964,O15269,O00592,Q9UBM7,P04062,O43681,Q15067,Q99720,Q96EK5,P07686,Q9NR77,Q9NQZ5,O95140,Q9NZJ7 23 +Coxa valga 0.638664449787693 2.127375068934599 0.0333889319206619 1.0 0.8211407869220101 17 P04066,O00754,O75844,P16278 4 +Eeg with spike wave complexes 0.7296416530940094 2.127070582781745 0.0334142190563764 1.0 0.8211407869220101 10 Q14108,O75503 2 +Cerebral inclusion bodies 0.6863700191151313 2.1236876244533303 0.0336962729058443 1.0 0.8211407869220101 12 P04062,P61916,O15118,P05067 4 +Abnormality of femur morphology 0.5460034697561265 2.1212603773156395 0.033899896791532 1.0 0.8211407869220101 57 O95831,P06280,P07602,Q9Y619,P16278,P51798,Q14739,O75844,Q9UHX1,P04062,Q32P28,P04066,Q96A33,O75718,Q9Y487,Q9BV10,O00754,P16435,Q9NZJ7 19 +Abnormal upper motor neuron morphology 0.7579513817933469 2.1089245440226896 0.0349510952643168 1.0 0.8211407869220101 9 Q13501,Q99720 2 +Abnormality of the spleen 0.4923303460164783 2.104974181142277 0.0352935555845015 1.0 0.8211407869220101 103 Q13510,P07602,P15586,Q14108,Q9NZ08,Q10713,P16278,P01889,P21964,P61916,O75845,Q14739,P54802,P04062,P10619,Q15392,Q16625,P04066,P28070,P38571,P10253,P08236,P07686,O15118,Q15904,O00754 26 +Aplasia hypoplasia involving the skeletal musculature 0.7563881427031609 2.1015181076124554 0.035595510157347 1.0 0.8211407869220101 9 Q9Y487,O43505 2 +Osteolysis 0.6195462599000787 2.093743247629516 0.0362828581540495 1.0 0.8211407869220101 27 P04062,Q13501,O75874,O75844,P53634,Q14108,O00754,P48735 8 +Cognitive impairment 0.5375906121184789 2.0935410198764735 0.0363008863056431 1.0 0.8211407869220101 147 Q13510,P12235,O75503,P50897,Q9BQE5,P06280,P07602,P05067,Q13501,Q9Y619,Q14108,P35637,P22626,Q6DKK2,P06865,Q06787,Q9NZ08,Q10713,P16278,P01889,P21964,P61916,P10644,O00429,P54802,O00592,Q5XKP0,P35670,O95470,P04062,O43681,P35270,Q9H2C2,Q9NPL8,P17900,Q9Y487,Q9H6K4,O75306,Q99720,P07686,O15118,Q9NQZ5,Q03164,O95140,O75569,Q9NZJ7 46 +Osteoarthritis 0.7224617137161395 2.091215680572725 0.0365087343117385 1.0 0.8211407869220101 10 P04062,Q14108,P01889,O75844,P35670 5 +Aplasia hypoplasia involving the vertebral column 0.6607679049502707 2.087135721531822 0.0368758678529757 1.0 0.8211407869220101 14 Q8TAA9,P16278,P10644,P08236,Q14739,P04066 6 +Micromelia 0.621678898909323 2.0852294901459856 0.0370484742253622 1.0 0.8211407869220101 20 Q15392,Q14739,O75874,Q9UHX1,Q9UBM7,O75718,P48735 7 +Hallucinations 0.5966580225525003 2.081583448971828 0.0373805344948843 1.0 0.8211407869220101 40 P04062,O75503,P21964,P50897,Q9BQE5,O00429,P07602,P05067,Q13501,O00592,P35637,O00754,Q6DKK2 13 +Abnormal thoracic spine morphology 0.6194571152471813 2.0795319999666195 0.0375684797384696 1.0 0.8211407869220101 24 P04062,P08236,O75477,O75845,O75844,Q9UHX1,P51648,O00754 8 +Progressive psychomotor deterioration 0.7510723202633864 2.0762847333769914 0.0378676244337357 1.0 0.8211407869220101 9 Q10713,P16278,O43681,P07602,P07686 5 +Hammertoe 0.6655601219909887 2.061562953363335 0.0392493641466173 1.0 0.8211407869220101 13 Q9UBM7,Q99720,Q9NR77,P07196,O95140,Q8N0X7 6 +Subcutaneous nodule 0.6365133732988695 2.0578757299707964 0.0396020640582048 1.0 0.8211407869220101 16 Q13510,P01889,P06280,O75874,P35637,P48735 6 +Slurred speech 0.7441666882466373 2.0433949069681865 0.0410133612400109 1.0 0.8211407869220101 9 O75787,P16278,Q9Y487 3 +Global brain atrophy 0.6132337724579378 2.0338355435723994 0.0419681795383084 1.0 0.8211407869220101 19 Q13501,P35637,P07602,Q9UHX1 4 +Motor neuron atrophy 0.6129750661207285 2.0328580367676405 0.0420668676451212 1.0 0.8211407869220101 21 Q13510,P35637,Q16637,Q13501,Q99720,P22626,Q92804 7 +Unusual infection by anatomical site 0.7108097930562475 2.032708734206081 0.0420819583557692 1.0 0.8211407869220101 10 Q8TAA9,Q14739,P02786,P01889 4 +Multiple prenatal fractures 0.8512082504670876 2.0323932703865055 0.0421138588298393 1.0 0.8211407869220101 5 Q14739,Q32P28 2 +Fatigable weakness of bulbar muscles 0.6415544857274792 2.032102304608032 0.0421433001396585 1.0 0.8211407869220101 15 P43243,Q15165,P50995,Q13501,Q9Y5P6,P35637,Q92804 7 +Nephrotic syndrome 0.6118486593553559 2.027243395854665 0.0426375271426924 1.0 0.8211407869220101 22 Q8NCH0,P06280,P51809,Q07021,Q9NQW6,Q14108 6 +Hypopigmented skin patches 0.6215083649839037 2.026213280420013 0.0427429333001048 1.0 0.8211407869220101 17 Q8IZA0,P07602 2 +Neuronal loss in central nervous system 0.6754384475704277 2.01594824297549 0.0438053881921565 1.0 0.8211407869220101 11 P35637,O15118,P07602 3 +Oromandibular dystonia 0.8842509762696813 2.0108872386425407 0.0443373685856873 1.0 0.8211407869220101 4 Q99720 1 +Fatigue 0.4956581718926832 2.000779368921929 0.0454161716980165 1.0 0.8211407869220101 65 P04062,P01889,Q13423,P10644,P06280,O00429,P07602,P50995,Q13501,Q14739,Q07021,Q02241,O00592,Q70HW3,P35637,Q92804,Q9NZJ7,Q9NZ08 18 +Hyperintensity of cerebral white matter on mri 0.6070281388480997 1.9960580332950233 0.0459276063326699 1.0 0.8211407869220101 19 P17900,O75503,P07602 3 +Paresthesia 0.6069383453463799 1.9956762906572845 0.0459691694204211 1.0 0.8211407869220101 21 P01889,Q9H6K4,P06280,P05067,Q9NR77,P54802,O95140,Q9NZ08 8 +Breech presentation 0.7993977413274662 1.993753065727233 0.0461790470175162 1.0 0.8211407869220101 7 Q9Y619,Q9UBM7 2 +Heparan sulfate excretion in urine 0.9602423324498306 1.9913881424970723 0.0464382318310354 1.0 0.8211407869220101 3 P15586,P54802 2 +Hypohidrosis 0.7643732938146172 1.9823597711762095 0.0474389887036528 1.0 0.8211407869220101 8 P06280 1 +Glomerulopathy 0.6997239968528443 1.976677589266396 0.0480780855792728 1.0 0.8211407869220101 10 Q14108,P06280,P01889 3 +Sea blue histiocytosis 0.9564558879212444 1.976476650496637 0.0481008177317363 1.0 0.8211407869220101 3 P61916,P16278 2 +Cerebral calcification 0.5995340260859301 1.9712632064692237 0.0486937775508573 1.0 0.8211407869220101 28 P23786,O00584,P05067,Q16625,P53634 5 +Aspiration 0.7935675147991255 1.968374739276829 0.0490249361833488 1.0 0.8211407869220101 7 P06865 1 +Vacuolated lymphocytes 0.953426732298372 1.9645357860636816 0.04946799045215 1.0 0.8211407869220101 3 P16278,P04066 2 +Cachexia 0.6201581688590844 1.962458895745233 0.0497090816488532 1.0 0.8211407869220101 16 P04062,P07602,Q99720,Q01844,P35637 5 +Abdominal pain 0.465694548501943 1.9598765681134969 0.0500102189936921 1.0 0.8211407869220101 70 P23786,P04062,Q14108,P01889,P10644,P06280,Q9Y4P3,P07686,Q01844,Q9NQW6,P42892,Q70HW3,P35637,Q9NZ08 14 +Sensory axonal neuropathy 0.6648749829238633 1.9593428596107845 0.0500726475860053 1.0 0.8211407869220101 11 Q8IV08,P22626,Q15067,O95140 4 +Abnormal choroid morphology 0.6006791073491736 1.9583980223443096 0.0501833266566933 1.0 0.8211407869220101 18 Q10713,P52732,P53701,P04439,P40939,Q5XKP0,Q9Y619,O43505 8 +Abnormal chorioretinal morphology 0.6006791073491736 1.9583980223443096 0.0501833266566933 1.0 0.8211407869220101 18 Q10713,P52732,P53701,P04439,P40939,Q5XKP0,Q9Y619,O43505 8 +Enlarged thorax 0.6468959653907647 1.9583498448633776 0.0501889756995619 1.0 0.8211407869220101 13 Q14739,P08236,O75844,P04066 4 +Elevated pulmonary artery pressure 0.5998389008567111 1.9532764297785945 0.050786848856817 1.0 0.8211407869220101 18 P04062,P01889,Q8IZA0,O75844,Q14108 5 +Fatigable weakness of respiratory muscles 0.6368059724881385 1.9524415280297551 0.0508858066754771 1.0 0.8211407869220101 14 Q13501,P35637,Q92804,P50995 4 +Parkinsonism 0.5972866006197047 1.9514730460444072 0.0510007995325558 1.0 0.8211407869220101 27 O75787,P07602,P05067,Q13501,Q99720,P35637,Q06787 7 +Pedal edema 0.8308375452105295 1.9484384855196184 0.0513625186055 1.0 0.8211407869220101 5 P04062,Q14108 2 +Adrenal insufficiency 0.598518603939396 1.9435466214489985 0.0519501480938326 1.0 0.8211407869220101 21 P38571,O00170,P33991,Q13423,Q99496,P51809,Q969G3,P16435,O75381,O95470,Q12824 11 +Hypoplastic vertebral bodies 0.8191418099387697 1.942839525263764 0.0520355506257985 1.0 0.8211407869220101 6 Q8TAA9,Q14739,P16278 3 +Thoracolumbar kyphosis 0.8189680902660381 1.9421143903467528 0.0521232537982196 1.0 0.8211407869220101 6 P08236,O00754 2 +Abnormal lumbar spine morphology 0.7229751500536622 1.9416928388844823 0.0521742961495725 1.0 0.8211407869220101 9 O00754,P08236,O75845 3 +Abnormal epiphyseal ossification 0.6347307629643771 1.940677053773315 0.0522974613281155 1.0 0.8211407869220101 14 Q14739,P08236,Q9UBM7 3 +Abnormality of visual evoked potentials 0.5974421546402661 1.936771597260181 0.0527732693015021 1.0 0.8211407869220101 20 O75503,O43681,Q15067,P07602,O95140,Q9NZJ7 6 +Aortic valve stenosis 0.786063814078686 1.9356090370060537 0.0529156027164123 1.0 0.8211407869220101 7 O75844,P16278 2 +Abnormality of lysosomal metabolism 0.8275970939339719 1.9350184889027489 0.0529880268876841 1.0 0.8211407869220101 5 Q13510,Q9NZJ7,P07602 3 +Fasciculations 0.587531947740804 1.9294945518153277 0.0536694957895289 1.0 0.8211407869220101 33 Q13510,O95831,P35637,Q16637,P06280,P07602,Q13501,P07686,P22626,Q9NZJ7,P51114 11 +Fatigable weakness of swallowing muscles 0.6410432793901728 1.9257307814627085 0.0541379982911536 1.0 0.8211407869220101 13 Q13501,P35637,Q92804,P50995 4 +Cupped ear 0.6894492767736856 1.9244279301093257 0.0543009663243192 1.0 0.8211407869220101 10 P42892 1 +Hypoplasia of the musculature 0.8241552898700439 1.9207453464662072 0.0547638197097679 1.0 0.8211407869220101 5 Q9Y487 1 +Abnormal rib cage morphology 0.4961240820968289 1.917347996802756 0.0551937361090233 1.0 0.8211407869220101 63 P16278,P08236,Q32P28,Q14739,P15586,O75844,P54802,P04066,O00754,Q9Y619,Q9UBM7,O75718,Q9UHX1 13 +Abnormal arterial physiology 0.5931668273607343 1.9170597530847064 0.0552303409197749 1.0 0.8211407869220101 25 P01889,Q9NWM8,P06280,P05067,Q14739,O75844,Q9NZ08 7 +Thoracic kyphosis 0.6292130809370635 1.909320230000767 0.0562207941659278 1.0 0.8211407869220101 14 P04062,P08236,Q9UHX1,P51648,O00754 5 +Hyperlipidemia 0.5918317759837338 1.9085319067984348 0.0563225033403393 1.0 0.8211407869220101 25 P38571,P23786,P50402,P06280,O75844,P28070 6 +Hyporeflexia of upper limbs 0.9371450208254464 1.9001807036901348 0.0574094096628985 1.0 0.8211407869220101 3 Q9NR77,Q15067 2 +Abnormal circulating gonadotropin concentration 0.6356682066041027 1.8956673978769496 0.0580040389502338 1.0 0.8211407869220101 13 P51809,Q969G3,P16435,Q12824,Q06787 5 +Abnormal large intestine physiology 0.5994162119120823 1.8941465422749493 0.0582055614498817 1.0 0.8211407869220101 17 Q8TAA9,P21964,P06280,O43681,P07602,Q06787 6 +Periventricular white matter hyperintensities 0.7114680360409114 1.8859840599804452 0.0592971027045376 1.0 0.8211407869220101 9 P17900,O43681,O75503,P07602 4 +Abnormal csf protein level 0.6818628306783258 1.8856537581976744 0.059341628064331 1.0 0.8211407869220101 10 O43681,P07602,Q16625,Q9NR77,Q9NZJ7 5 +Abnormal retinal artery morphology 0.5888594047931075 1.8835799790196168 0.0596218120966307 1.0 0.8211407869220101 20 P16278,P10619,P07602,P07686,P17900,P06865 6 +Neck flexor weakness 0.93219421789772 1.8805561576014027 0.0600323204137875 1.0 0.8211407869220101 3 Q99720 1 +Dyscalculia 0.7099563428547577 1.8786405006005915 0.0602935971191163 1.0 0.8211407869220101 9 Q13501,P35637,Q06787 3 +Metatarsus adductus 0.6401690735724017 1.872226752773411 0.0611752393866382 1.0 0.8211407869220101 12 Q9UBM7,Q15392 2 +Juvenile onset 0.5689452666434688 1.870545388438943 0.0614081202195773 1.0 0.8211407869220101 39 Q13510,P16278,P50402,P06280,Q9NR77,P54802,O15118,O14773 8 +Chondrosarcoma 0.92957213176827 1.870152220151733 0.0614626825688171 1.0 0.8211407869220101 3 O75874,P48735 2 +Intrinsic hand muscle atrophy 0.847909601004696 1.863069250028732 0.0624525238712467 1.0 0.8211407869220101 4 Q9NR77 1 +Epiphyseal stippling 0.6770780194669211 1.8611140056442113 0.0627280787745112 1.0 0.8211407869220101 10 Q14739,P08236,Q9UBM7 3 +Avascular necrosis 0.5850547806896725 1.8598624221186415 0.0629049930790219 1.0 0.8211407869220101 22 P04062,P01889,O75844,Q9Y619,Q14108,O00754 6 +Abnormal placenta morphology 0.768372011849615 1.8579021535990776 0.0631829105223269 1.0 0.8211407869220101 7 P16278 1 +Coarse hair 0.6023909807965995 1.8575983837808565 0.0632260682229821 1.0 0.8211407869220101 16 P15586,P54802,Q9Y487,Q9Y5P4 4 +Abnormal mitochondria in muscle tissue 0.6113113670973532 1.857536231599634 0.0632349014146791 1.0 0.8211407869220101 15 O96000,Q96CU9,O43676,O75306 4 +Tissue ischemia 0.584129561105434 1.8552071828141927 0.0635666463674617 1.0 0.8211407869220101 19 P01889,P06280,P05067,O75844,Q9NZ08 5 +Multifocal cerebral white matter abnormalities 0.8083509975702887 1.8549536952381855 0.063602839223352 1.0 0.8211407869220101 5 P10253 1 +Barrel shaped chest 0.922377887163952 1.8415713410143624 0.0655378763206107 1.0 0.8211407869220101 3 Q14739,P04066 2 +Decreased light and dark adapted electroretinogram amplitude 0.9215240114030016 1.8381757218467232 0.0660365160685978 1.0 0.8211407869220101 3 P50897 1 +Abnormal vascular physiology 0.5580616098563146 1.8376444926553548 0.0661148080699907 1.0 0.8211407869220101 42 O96000,P04062,P01889,P06280,Q9NWM8,P05067,Q14739,Q8IZA0,O75844,Q14108,Q9NZ08 11 +High frequency sensorineural hearing impairment 0.8412630733687876 1.835837287545672 0.0663817249273459 1.0 0.8211407869220101 4 Q13510,O75844 2 +Degeneration of the lateral corticospinal tracts 0.8036054452930751 1.8351191641878457 0.0664880349854966 1.0 0.8211407869220101 5 Q13501 1 +Neoplasm of the adrenal cortex 0.8410069803895466 1.8347868633835291 0.0665372758064002 1.0 0.8211407869220101 4 O75874,P48735 2 +Erlenmeyer flask deformity of the femurs 0.8405303030303077 1.8328314331083455 0.0668276430751042 1.0 0.8211407869220101 4 P04062,Q9NZJ7,P07602 3 +Macrogyria 0.8027558656635331 1.831564454593166 0.0670163366448535 1.0 0.8211407869220101 5 Q15392 1 +Paroxysmal involuntary eye movements 0.6240690340278475 1.8304471864151113 0.0671830972814413 1.0 0.8211407869220101 13 O96000,Q96CU9,O43676,O75306 4 +Ascending tubular aorta aneurysm 0.8397050389719398 1.8294453253473613 0.0673329228457766 1.0 0.8211407869220101 4 O75844,Q06787 2 +Primary adrenal insufficiency 0.6705723761615195 1.827644282960352 0.06760295520313 1.0 0.8211407869220101 10 Q9NRG9,Q13423,Q99496,Q969G3,P16435,O75381,Q12824 7 +Pustule 0.9188463911263838 1.8275230169353411 0.0676211687260568 1.0 0.8211407869220101 3 P07858 1 +Vertical supranuclear gaze palsy 0.7303886564103725 1.8258222310513612 0.0678770435099218 1.0 0.8211407869220101 8 P61916,O15118 2 +Meningitis 0.8004430808552404 1.821881763543796 0.0684729279468303 1.0 0.8211407869220101 5 Q8TAA9,P02786,P01889 3 +Abnormal head movements 0.6976155094054173 1.8184749604603363 0.068991570409689 1.0 0.8211407869220101 9 Q99720,P35637 2 +Dysdiadochokinesis 0.6132079642414862 1.8177353325494232 0.0691045947023245 1.0 0.8211407869220101 14 Q13501,O75503,Q6DKK2 3 +Bone marrow foam cells 0.9155622870124972 1.814448108858396 0.0696087648157153 1.0 0.8211407869220101 3 P61916,O15118 2 +Disproportionate short trunk short stature 0.8357876904065913 1.8133601531097807 0.0697762911262027 1.0 0.8211407869220101 4 P16278 1 +Goiter 0.79714693482849 1.808067525511824 0.0705959916961171 1.0 0.8211407869220101 5 O75874,P48735 2 +Sparse body hair 0.6663749188606224 1.8059861002849853 0.0709205107487629 1.0 0.8211407869220101 10 Q14574,P53634,Q06787 3 +Hypokinesia 0.756227553451202 1.804197629081411 0.0712003309017548 1.0 0.8211407869220101 7 P12235,P04062,O95831 3 +Abnormal visual fixation 0.7854496778576978 1.8011798326886257 0.0716745399922231 1.0 0.8211407869220101 6 Q13510,Q5KU26 2 +Abnormal metatarsal morphology 0.5753668189435626 1.8007044310665847 0.0717494788352184 1.0 0.8211407869220101 19 Q9UBM7,O43505,Q15392 3 +Abnormality of pulmonary circulation 0.5755749470068903 1.7998742440690054 0.0718804973746982 1.0 0.8211407869220101 22 P04062,P01889,Q8IZA0,O75844,Q14108,Q9NZ08 6 +Retinal detachment 0.6184631872517683 1.798758716065896 0.0720568564262997 1.0 0.8211407869220101 13 P52732,Q8NCH0,Q99496,P04439,Q9Y5P6,Q9BV10,O43505 7 +Generalized hyperkeratosis 0.8320672997608239 1.7980654794692703 0.072166631886164 1.0 0.8211407869220101 4 O75844 1 +Nemaline bodies 0.8313232274472289 1.7950044607121227 0.0726529892325476 1.0 0.8211407869220101 4 O43676 1 +Cerebral hemorrhage 0.6258402349546385 1.7927727393879695 0.0730092701144589 1.0 0.8211407869220101 12 P23786,P05067,Q99496,Q969G3,Q12824 5 +Hypotension 0.5736444768654579 1.787708320709488 0.0738230786010532 1.0 0.8211407869220101 21 P04062,Q13423,O43681,P07602,P07686,O43772,Q06787 7 +Hepatosplenomegaly 0.5665153400128674 1.786679881183675 0.0739892426049233 1.0 0.8211407869220101 33 Q13510,P04062,P16278,P10619,O75845,Q14739,P07686,O00754 8 +Nasogastric tube feeding in infancy 0.7520684880432061 1.7857389342795993 0.0741415382122168 1.0 0.8211407869220101 7 Q92734,P07602,Q9UHX1,P61978,Q9NZJ7 5 +Abnormal neuron morphology 0.572652525725052 1.785117141592172 0.0742423180970504 1.0 0.8211407869220101 25 Q13510,P35637,Q16637,Q13501,Q99720,P22626,Q92804 7 +Abnormality of head blood vessel 0.5727677931200982 1.7820341786557643 0.0747436582653591 1.0 0.8211407869220101 22 P16278,P10619,P07602,P07686,P17900,P06865 6 +Ulnar deviation of the wrist 0.8276575475329649 1.7799141806062582 0.0750900065900577 1.0 0.8211407869220101 4 Q9BV10,P16278 2 +Telangiectasia of the skin 0.6066153676989814 1.7797414509592278 0.0751182834206223 1.0 0.8211407869220101 14 P06280,Q8IZA0 2 +Bone pain 0.5710529045459113 1.771617218469208 0.0764581195025768 1.0 0.8211407869220101 23 P04062,P10644,P35670,P07602,Q13501,O75874,Q14108,Q9NZJ7,P48735 9 +Short nail 0.8251279764070096 1.7694911202675143 0.0768119513400114 1.0 0.8211407869220101 4 O75844 1 +Postural instability 0.5869372566752288 1.7653787045759584 0.0775001399573342 1.0 0.8211407869220101 16 Q9NR77,O75503,O00592 3 +Abnormality of the gingiva 0.5480159828649012 1.7636788831681611 0.0777860583528946 1.0 0.8211407869220101 42 P04062,P16278,P10644,P08236,O75845,Q15392,Q14739,Q02241,P53634,Q14108,Q9UBM7,O00754 12 +Paraparesis 0.5686949124636586 1.762003280470006 0.0780687432256475 1.0 0.8211407869220101 26 Q13510,P04062,Q9H6K4,O75787,Q13501,Q5XKP0,Q9Y619,P35637,Q8N0X7,Q6DKK2 10 +Sensory ataxia 0.8232926964560077 1.7619239637529769 0.0780821451681448 1.0 0.8211407869220101 4 P54802 1 +Abnormal autonomic nervous system physiology 0.5675513572726145 1.7618000388265531 0.078103088194982 1.0 0.8211407869220101 28 P06280,P07602,Q15067,P07686,P42892,O00592,Q06787 7 +Dysesthesia 0.775184619019152 1.7576207084172517 0.0788120674008034 1.0 0.8211407869220101 6 Q9NR77,Q8NCH0,Q06787 3 +Elevated serum acid phosphatase 0.8221032062373347 1.757017315830889 0.0789148577700291 1.0 0.8211407869220101 4 Q9NZJ7,P07602 2 +Abnormal biliary tract morphology 0.5687349027536155 1.756627971301686 0.0789812420572926 1.0 0.8211407869220101 21 P14174,P04062,Q10713,O43681,P07602,Q14739,Q5XKP0,Q14108,Q9NZJ7 9 +Diffuse white matter abnormalities 0.7744081965953501 1.7543186409038956 0.0793759234095174 1.0 0.8211407869220101 6 O43819,O75306,Q9Y5P6,P16278 4 +Ambiguous genitalia 0.5676668953912868 1.7525393858890292 0.0796811035702638 1.0 0.8211407869220101 19 Q8TAA9,Q2VPK5,O75845,Q15392,Q9UBM7 5 +Schizophrenia 0.5842520486790489 1.749259723441539 0.0802461346463712 1.0 0.8211407869220101 16 P04062,P21964,Q9BQE5,O43681,P07602,Q9NZJ7 6 +Hyperpituitarism 0.5662714660336134 1.743783459542177 0.0811968557487936 1.0 0.8211407869220101 19 O00170,P10644,Q99496,P51809,Q969G3,P16435,Q12824,Q06787 8 +Abnormal exteroceptive sensation 0.5383913633750144 1.7433942081967373 0.081264779306172 1.0 0.8211407869220101 45 O95831,O15270,P01889,Q9H6K4,O15269,P06280,Q8NCH0,P07602,P05067,P07686,Q9NR77,P54802,O95140,Q9NZJ7,Q9NZ08,Q06787 16 +Decreased circulating acth level 0.7817355058734389 1.7432543818018715 0.0812891899794652 1.0 0.8211407869220101 5 Q969G3,P10644,Q12824,Q99496 4 +Tinnitus 0.6083197964675728 1.7411458104193644 0.08165802312594 1.0 0.8211407869220101 13 O95831,Q02978,Q99496,Q969G3,Q9NR77,O95140,Q12824 7 +Hypoglycemic seizures 0.7419059336850633 1.7404948969127814 0.0817721553575179 1.0 0.8211407869220101 7 Q13423,P00367,Q16836,P53985 4 +Abnormality of the autonomic nervous system 0.5445341697986339 1.7379066019303206 0.0822272722166101 1.0 0.8211407869220101 42 P04062,Q10713,P21964,O15269,P06280,O43681,P07602,Q15067,Q96EK5,P07686,P42892,O00592,Q9UBM7,Q9NZJ7,Q06787 15 +Titubation 0.7111376897164665 1.7360066334130528 0.0825626616686709 1.0 0.8211407869220101 8 Q99720,Q5JRX3 2 +Proportionate short stature 0.5638044006448174 1.733083894076499 0.083080758579219 1.0 0.8211407869220101 27 P16278,Q16836,P10619,Q15392,Q14739,Q9Y619 6 +Gingival bleeding 0.6231907595454578 1.7324450163030063 0.0831943588069681 1.0 0.8211407869220101 11 P04062,Q14108,P10644 3 +Progressive cerebellar ataxia 0.5585811398902973 1.7321856208320063 0.083240518375905 1.0 0.8211407869220101 33 Q9Y487,Q96CU9,Q13501,Q9Y619,P35637,O14773 6 +Echolalia 0.6795936798019919 1.7299327363008274 0.0836422936118592 1.0 0.8211407869220101 9 O75787,Q13501 2 +Transient ischemic attack 0.7394836963406487 1.7296818964554233 0.0836871249158877 1.0 0.8211407869220101 7 P06280 1 +Bilateral sensorineural hearing impairment 0.5637816908307584 1.7251651107111927 0.0844977213011271 1.0 0.8211407869220101 21 O43681,P07602,P38159,Q13501,Q15067,P35637,Q9NZJ7 7 +Joint subluxation 0.7763517502152054 1.720528267684751 0.0853364598912309 1.0 0.8211407869220101 5 P16278 1 +Abnormality of the larynx 0.5441584018237628 1.7198710398952248 0.0854558857712639 1.0 0.8211407869220101 41 Q13510,P21964,P07602,P50995,Q13501,Q14739,P16435,Q9UHX1,P35637,Q9UBM7,Q92804 11 +Abnormal brainstem mri signal intensity 0.5877933006418865 1.7193948646576571 0.0855424966868108 1.0 0.8211407869220101 15 O96000,Q96CU9,O75306,O43676,Q9NPL8 5 +Chronic fatigue 0.8129369474037441 1.719149960727287 0.0855870695778693 1.0 0.8211407869220101 4 Q13423,P07602 2 +Talipes calcaneovalgus 0.8124729848621008 1.717230643154844 0.085937038711503 1.0 0.8211407869220101 4 Q9UBM7 1 +Endocarditis 0.775517390428248 1.7170024134810355 0.085978731014396 1.0 0.8211407869220101 5 P04062,P01889,Q9NZ08 3 +Hypoketotic hypoglycemia 0.7353304561076333 1.711115871258256 0.0870597248541655 1.0 0.8211407869220101 7 P23786,O43772 2 +Airway obstruction 0.6192223709146986 1.7105564653880585 0.0871630213805947 1.0 0.8211407869220101 11 P21964,P06280,O75844,P16435 4 +Ventricular hypertrophy 0.5564465275084949 1.7099405061398816 0.0872768751091903 1.0 0.8211407869220101 32 P12235,P23786,P10253,O75787,O95630,P06280,Q07021,Q9BV10,O75844,O43772 10 +Neurodegeneration 0.5602926672540205 1.7069159978851554 0.0878376668619318 1.0 0.8211407869220101 26 P08236,Q13501,P35637,Q6DKK2,P17900 5 +Angina pectoris 0.8884380885744205 1.706092277059411 0.087990900252032 1.0 0.8211407869220101 3 P06280 1 +Shoulder girdle muscle weakness 0.6470618360349116 1.705702526214651 0.0880634790879002 1.0 0.8211407869220101 10 O14979,Q9NZJ7,P07602 3 +Hypoplasia of the odontoid process 0.7724748949564805 1.7041367862980024 0.0883555355381671 1.0 0.8211407869220101 5 P16278 1 +Contractures of the joints of the upper limbs 0.5003439572930037 1.7029062363677483 0.0885856167735286 1.0 0.8211407869220101 56 P23786,Q15392,Q99720,Q9NR77,Q8IZA0,O75844,P42892,Q9Y619,P35637 9 +Abnormality of the alveolar ridges 0.7036782593117695 1.7009899798606667 0.0889448687699381 1.0 0.8211407869220101 8 Q9UBM7,Q15392 2 +Skin nodule 0.5590567340097484 1.698381111859666 0.0894358546627214 1.0 0.8211407869220101 19 Q13510,P06280,O75874,P35637,P48735 5 +Abnormality of the lymphatic system 0.4748306248560209 1.6977024818249833 0.0895639291238985 1.0 0.8211407869220101 122 Q13510,P07602,P15586,O75874,Q01844,Q14108,Q9NZ08,Q10713,P16278,P01889,P21964,P61916,P10644,O75845,Q14739,P54802,P04062,P10619,Q15392,Q16625,P04066,P28070,P38571,P10253,P08236,P07686,O15118,Q15904,O00754,P48735 30 +Protuberant abdomen 0.8069375775232819 1.6943129509275612 0.0902058308844739 1.0 0.8211407869220101 4 P04062 1 +Facial hemangioma 0.8068621993209296 1.6940006329601307 0.0902651627683543 1.0 0.8211407869220101 4 Q9UBM7 1 +Wide intermamillary distance 0.5581960465944041 1.6929501098175317 0.0904649639672385 1.0 0.8211407869220101 19 P23786,Q9UBM7,Q96EK5,Q9Y5P4 4 +Visual fixation instability 0.8840802240120349 1.6886275722270407 0.0912908233794951 1.0 0.8211407869220101 3 Q5KU26 1 +Abnormal pericardium morphology 0.7004482598716456 1.6857911316342815 0.0918360365193313 1.0 0.8211407869220101 8 P04062,Q14108,P01889,Q9NZ08 4 +Left ventricular hypertrophy 0.5573319836344223 1.6840377010211782 0.0921743828730756 1.0 0.8211407869220101 21 P12235,O75208,O00170,P10253,O75787,P06280,P00403,Q07021,P40939,Q7L0Y3 10 +Slow pupillary light response 0.8040443949487268 1.6823210034765554 0.092506610447264 1.0 0.8211407869220101 4 P07602 1 +Abnormal pupillary light reflex 0.8040443949487268 1.6823210034765554 0.092506610447264 1.0 0.8211407869220101 4 P07602 1 +Abnormal sensory nerve conduction velocity 0.802272727272732 1.6749731136043653 0.0939395069801403 1.0 0.8211407869220101 4 O15269,O95140,Q9NR77 3 +Corpus callosum atrophy 0.5962726797008002 1.672266852880876 0.0944717128708205 1.0 0.8211407869220101 13 O00754,O75503 2 +Decreased pulmonary function 0.8015151515151564 1.671830079245125 0.0945578336474195 1.0 0.8211407869220101 4 Q969G3,P08236,Q12824 3 +Abnormal central sensory function 0.8015151515151553 1.6718300792451206 0.0945578336474204 1.0 0.8211407869220101 4 O75787,Q969G3,Q12824 3 +Hemifacial spasm 0.8015151515151536 1.671830079245114 0.0945578336474217 1.0 0.8211407869220101 4 Q969G3,Q10713,Q12824 3 +Mixed hearing impairment 0.7648255343877068 1.6717317454136371 0.0945772312808848 1.0 0.8211407869220101 5 O00754 1 +Heteronymous hemianopia 0.7648004693855099 1.6716254265840638 0.0945982076475391 1.0 0.8211407869220101 5 Q969G3,Q12824,Q99496 3 +Abnormal systemic blood pressure 0.4273972478271385 1.6712139103830783 0.0946794336315259 1.0 0.8211407869220101 72 Q8TAA9,P38571,P04062,Q10713,P01889,P21964,P10644,Q13423,P06280,O43681,P07602,Q9Y4P3,P07686,O75844,P42892,O43772,P16435,Q06787 18 +Increased circulating gonadotropin level 0.6402684722122644 1.6701860274750435 0.0948825636115771 1.0 0.8211407869220101 10 Q06787,P51809 2 +Neoplasm of the parathyroid gland 0.8009512380711871 1.6694901134368834 0.0950202881011179 1.0 0.8211407869220101 4 O75874,P48735 2 +Parathyroid adenoma 0.8009512380711871 1.6694901134368834 0.0950202881011179 1.0 0.8211407869220101 4 O75874,P48735 2 +Abnormality of the parathyroid morphology 0.8009512380711871 1.6694901134368834 0.0950202881011179 1.0 0.8211407869220101 4 O75874,P48735 2 +Cataplexy 0.8004879517092736 1.6675674474026068 0.095401624849194 1.0 0.8211407869220101 4 P61916 1 +Calcinosis 0.7624034233668082 1.6614537820645383 0.0966223439311204 1.0 0.8211407869220101 5 O75844 1 +Pericardial effusion 0.7987822817429948 1.6604868569514932 0.0968165497589104 1.0 0.8211407869220101 4 Q14108 1 +Arm dystonia 0.798735597981767 1.660293019883048 0.0968555192565814 1.0 0.8211407869220101 4 Q99720 1 +Increased susceptibility to fractures 0.5222344191248656 1.65729709828805 0.0974594236840808 1.0 0.8211407869220101 47 P04062,Q14108,O15270,Q13126,P10644,O15269,P35670,O75845,Q32P28,Q13501,Q14739,O75874,P16435,P22626,O75718,P48735 16 +Asymmetric septal hypertrophy 0.9803179409538224 1.6566124402902265 0.0975978555923995 1.0 0.8211407869220101 2 P15586 1 +Cerebral hypoplasia 0.6014898418409953 1.6562019895056237 0.0976809204948259 1.0 0.8211407869220101 12 Q9UBM7 1 +Abscess 0.7609171974013846 1.6551431314208769 0.0978954675837047 1.0 0.8211407869220101 5 P53634 1 +Cns demyelination 0.5928861403421624 1.6528172971828266 0.098368052680446 1.0 0.8211407869220101 13 P51648,Q15067,P07602 3 +Abnormalities of placenta or umbilical cord 0.6007828094743866 1.6522081400474686 0.0984921276266486 1.0 0.8211407869220101 12 P16278 1 +Abnormal cerebral artery morphology 0.6007457275384195 1.651998630032825 0.0985348301235471 1.0 0.8211407869220101 12 P10253,P05067 2 +Oculomotor apraxia 0.5520204295876913 1.649110052007151 0.0991250906784464 1.0 0.8211407869220101 22 P04062,Q10713,P35270,P05067,Q13501,O14773 6 +Hypersplenism 0.6630679607880273 1.6480525315888863 0.0993418918792592 1.0 0.8211407869220101 9 P04062,Q14108,P07602 3 +Vertebral compression fracture 0.5756381731126636 1.6471966718748414 0.0995176276848794 1.0 0.8211407869220101 15 P04062,Q14108,Q32P28 3 +Intracellular accumulation of autofluorescent lipopigment storage material 0.9776684330052984 1.6457707901033032 0.0998109582384998 1.0 0.8211407869220101 2 O75503 1 +Hypocholesterolemia 0.7207432787186626 1.645654975020366 0.0998348138150815 1.0 0.8211407869220101 7 Q9UBM7,Q9BV10,Q9NZJ7,P07602 4 +Poor head control 0.4935624093078851 1.6445250019926525 0.1000678042137146 1.0 0.8211407869220101 56 O96000,Q10713,Q96CU9,O75306,O43676,Q9NWM8,P07602,Q9H2C2,Q9NPL8,Q5XKP0,Q5KU26,P17900,P06865 13 +Abnormal lung lobation 0.5986052341858078 1.6398976974921011 0.1010264396942017 1.0 0.8211407869220101 12 Q9UHX1,Q14739,Q9UBM7 3 +Abnormality of circulating glucocorticoid level 0.6907083052265974 1.6398291238086025 0.1010407008788087 1.0 0.8211407869220101 8 Q13423,P10644,Q99496,Q969G3,P16435,Q12824 6 +Coarse facial features 0.5058136680936622 1.6379005856880118 0.1014424337816364 1.0 0.8211407869220101 52 P16278,P10619,P08236,P06280,P15586,P07686,P54802,P04066,O00754 9 +Abnormal pupillary function 0.7468684413039168 1.636546187702035 0.1017253273973113 1.0 0.8211407869220101 6 P07602 1 +Decreased circulating cortisol level 0.7463987869598121 1.634527125808242 0.1021482152953985 1.0 0.8211407869220101 6 Q13423,Q99496,Q969G3,P16435,Q12824 5 +Occipital encephalocele 0.7921655038706088 1.6329907097164411 0.1024709505948715 1.0 0.8211407869220101 4 Q10713,O43505 2 +Neoplasm of the adrenal gland 0.6331445346500115 1.6328095749418814 0.102509052663571 1.0 0.8211407869220101 10 O75874,P48735 2 +Cold induced muscle cramps 0.8694528234480923 1.6299087734210986 0.1031207791203256 1.0 0.8211407869220101 3 P23786 1 +Generalized clonic seizure 0.7908721538253793 1.627610998994853 0.1036073954167577 1.0 0.8211407869220101 4 P07602 1 +Micronodular cirrhosis 0.754366965861466 1.6272945074179772 0.1036745638940903 1.0 0.8211407869220101 5 P11717 1 +Skin ulcer 0.5485140271415797 1.6263976229456816 0.1038650961881806 1.0 0.8211407869220101 24 P04062,P01889,O15269,Q14739,O75874,Q8IZA0,P48735 7 +Color vision defect 0.5960506960499116 1.625437292137371 0.104069415237268 1.0 0.8211407869220101 12 Q9H6K4,Q9H061,O00429,Q6P4Q7,O00592 5 +Anarthria 0.7159418230627995 1.6240242246218146 0.1043706385608385 1.0 0.8211407869220101 7 Q99720,P35637 2 +Thoracic scoliosis 0.6308351873018347 1.6206648642810682 0.1050895328803764 1.0 0.8211407869220101 10 Q9UHX1,O75844 2 +Chronic diarrhea 0.5624754606197646 1.6175180048101785 0.1057665124000084 1.0 0.8211407869220101 16 P02786,P07686,Q15904 3 +Myositis 0.6567131261024777 1.6163967713160723 0.1060085559882919 1.0 0.8211407869220101 9 P28070,P22626,P01889 3 +Weak voice 0.7416180457979364 1.613955079487807 0.1065371701867226 1.0 0.8211407869220101 6 O75787,O00592 2 +Periventricular heterotopia 0.6848652511387731 1.6121641255175354 0.1069262295442392 1.0 0.8211407869220101 8 Q9UBM7,Q06787 2 +Abnormal intraocular pressure 0.7507089548270688 1.6117174575950408 0.1070234370101919 1.0 0.8211407869220101 5 P04439,Q8NCH0 2 +Head titubation 0.738292007876314 1.599622122877614 0.109682437635487 1.0 0.8211407869220101 6 Q99720 1 +Anorexia 0.5433184146203229 1.5985831019659609 0.1099132668838187 1.0 0.8211407869220101 19 P04062,P01889,P10644,P06280,Q14108,Q9NZ08 6 +Abnormal gastrointestinal motility 0.5441367704733687 1.5981149199200697 0.1100174037534857 1.0 0.8211407869220101 22 Q9UBM7,P06280,Q01844 3 +Abnormal circulating follicle stimulating hormone concentration 0.7098952560189067 1.596726847144366 0.1103266084803864 1.0 0.8211407869220101 7 Q969G3,P16435,Q12824,P51809 4 +Focal segmental glomerulosclerosis 0.5505047882861999 1.5946468296099254 0.1107912342503023 1.0 0.8211407869220101 17 Q14108,Q9NQW6 2 +Progressive spastic quadriplegia 0.6809468835252168 1.593574082829158 0.1110314631868363 1.0 0.8211407869220101 8 P17900,O43681,P07602 3 +Athetosis 0.5824496130634398 1.592642784287568 0.1112403497523595 1.0 0.8211407869220101 13 O00584,O14949 2 +Flat face 0.5418168631363862 1.5922968880995032 0.1113180118442886 1.0 0.8211407869220101 18 O00754,P08236,Q9Y487,Q15555 4 +Abnormal cervical spine morphology 0.7461108622246675 1.592112666045003 0.1113593916290747 1.0 0.8211407869220101 5 P04066 1 +Hemianopia 0.7082892143982842 1.5894657646494172 0.1119552773352348 1.0 0.8211407869220101 7 O00170,P00403,Q99496,Q969G3,Q12824 5 +Secondary growth hormone deficiency 0.7814393939393961 1.5883265880260256 0.1122125082597582 1.0 0.8211407869220101 4 Q969G3,Q12824,Q99496 3 +Ankle clonus 0.5891974818537136 1.5865438998697952 0.1126159819275041 1.0 0.8211407869220101 12 O75787,Q9NZJ7,P07602 3 +Decerebrate rigidity 0.744644090687954 1.585853180942601 0.1127726185711446 1.0 0.8211407869220101 5 O43681,P16278,P07602 3 +Abnormal size of pituitary gland 0.7803635258514244 1.5838406966588885 0.1132299755369028 1.0 0.8211407869220101 4 Q969G3,Q12824 2 +Abnormality of circulating adrenocorticotropin level 0.6787793076927913 1.5832775369485934 0.1133582204980834 1.0 0.8211407869220101 8 Q13423,P10644,Q99496,Q969G3,P16435,Q12824 6 +Abnormal size of the clitoris 0.5885632520251534 1.5829372583890902 0.1134357655213595 1.0 0.8211407869220101 12 Q9Y619,Q9UBM7,P51809 3 +Retrocollis 0.8572510412722514 1.5808262130048238 0.1139177792325103 1.0 0.8211407869220101 3 Q99720,P35637 2 +Arthritis 0.5314252211048963 1.5772345033043589 0.1147415766291892 1.0 0.8211407869220101 37 Q13510,P04062,P01889,P21964,P06280,Q14739,O75844,P10321,P28070,Q14108,Q9NZ08 11 +Obsessive compulsive trait 0.7782054451064357 1.5748393542977484 0.115293529975522 1.0 0.8211407869220101 4 O75503 1 +Fluctuations in consciousness 0.7419477074649532 1.574339309424735 0.1154090265326595 1.0 0.8211407869220101 5 O43819,P04062,P00403,O75306 4 +Premature rupture of membranes 0.7323451365024534 1.573953780858479 0.1154981350814421 1.0 0.8211407869220101 6 O75844 1 +Corneal erosion 0.7778695733631859 1.573438067107799 0.1156174183530378 1.0 0.8211407869220101 4 Q96EK5,P01889 2 +Abnormal circulating copper concentration 0.7315973137701176 1.5707222729764228 0.1162471732910144 1.0 0.8211407869220101 6 O43819,P35670,Q15904,Q9Y487 4 +Erectile dysfunction 0.6760281633287697 1.5701958760370422 0.1163695486920173 1.0 0.8211407869220101 8 Q99496,Q969G3,P07686,Q12824,Q06787 5 +Impotence 0.6760281633287697 1.5701958760370422 0.1163695486920173 1.0 0.8211407869220101 8 Q99496,Q969G3,P07686,Q12824,Q06787 5 +Emg neuropathic changes 0.5397662097148388 1.5697314040811512 0.1164776119660853 1.0 0.8211407869220101 22 Q13510,Q16637,O43681,P07602,O95140,Q9NR77,P22626,O14773 8 +Blindness 0.446066548668649 1.569020204324501 0.1166432312713448 1.0 0.8211407869220101 66 P50897,P07602,Q9NZ08,P06865,O96000,P01889,P16278,P51798,Q9NPL8,Q12824,O43505,P17900,P52732,Q9H6K4,Q15555,Q96CU9,O75306,O43676,Q969G3,P07686,Q9NZJ7 21 +Acetabular dysplasia 0.730955934206994 1.5679500793763528 0.1168927830919726 1.0 0.8211407869220101 6 P16278 1 +Postural tremor 0.5461297918119878 1.5673955567994609 0.1170222618912342 1.0 0.8211407869220101 17 Q9H6K4,P35637,O75306,O95140,Q9NR77,Q14108,O14773,Q06787 8 +Undetectable electroretinogram 0.7396087417269035 1.5643444280486682 0.1177367037904286 1.0 0.8211407869220101 5 P50897 1 +Abnormal spermatogenesis 0.6461152768473428 1.563403200731558 0.1179577877920623 1.0 0.8211407869220101 9 Q13423,P04062,P51809 3 +Gingival overgrowth 0.5384923138232127 1.5625052741163874 0.1181690043749792 1.0 0.8211407869220101 26 P16278,P10644,P08236,O75845,Q14739,Q9UBM7,O00754 7 +Patchy changes of bone mineral density 0.7752429677170307 1.5624762753304378 0.1181758306142461 1.0 0.8211407869220101 4 Q13501,Q14739 2 +Abnormality of the ribs 0.4873205790052915 1.5617295239580382 0.118351720516022 1.0 0.8211407869220101 55 P16278,Q32P28,Q14739,P15586,O75844,P54802,O00754,Q9Y619,Q9UBM7,O75718,Q9UHX1 11 +Sepsis 0.5610035935929365 1.5595709142799503 0.1188613143470913 1.0 0.8211407869220101 15 P02786,P42892 2 +Abnormality of the odontoid process 0.728797315215086 1.5586156350971003 0.1190873802173189 1.0 0.8211407869220101 6 P16278 1 +Bifid scrotum 0.7379026638461272 1.557049839557375 0.1194586528606074 1.0 0.8211407869220101 5 Q96EK5,Q9UBM7 2 +Impaired temperature sensation 0.7283804802779726 1.556812355259783 0.1195150429225084 1.0 0.8211407869220101 6 Q9NR77,P07686,O15269,O95140 4 +Diarrhea 0.4864500574573959 1.554234835664127 0.1201284108910352 1.0 0.8211407869220101 55 Q13510,P38571,Q16836,P01889,P02786,P06280,P15586,P07686,Q02241,P54802,P42892,O00592,Q96A33,Q15904 14 +Abnormality of subcutaneous fat tissue 0.5833736696707322 1.5533804138952685 0.1203322792669254 1.0 0.8211407869220101 12 O75844 1 +Vertebral hypoplasia 0.6175770219291222 1.5506778218739818 0.1209789119978632 1.0 0.8211407869220101 10 Q8TAA9,Q14739,P16278 3 +Infantile axial hypotonia 0.6717154263088001 1.5496599592681914 0.1212231534115302 1.0 0.8211407869220101 8 P17900,P07602 2 +Multifactorial inheritance 0.5898676850900891 1.5471652725775469 0.1218233976404519 1.0 0.8211407869220101 11 P42892,P10321 2 +Cerebral palsy 0.6168064266060647 1.5465965072387788 0.1219605724866192 1.0 0.8211407869220101 10 O75874,P48735 2 +Insidious onset 0.7710337644539189 1.5448976449125311 0.1223710232131987 1.0 0.8211407869220101 4 Q9NR77 1 +Cerebral white matter atrophy 0.5417819125604726 1.5402413341996102 0.1235015379186998 1.0 0.8211407869220101 17 O00754,O75503 2 +Bradykinesia 0.5343695019556621 1.538460701025042 0.1239360102862303 1.0 0.8211407869220101 20 P12235,P04062,O75787,P35270,O00592,O75569,Q6DKK2,Q06787 8 +Macroglossia 0.5340049718306429 1.5369555870074831 0.1243041857180795 1.0 0.8211407869220101 28 P10253,Q10713,P16278,Q9Y4P3,P07686,Q9Y5P6,P04066,P61978,Q96A33,O00754,Q12824,O60828 12 +Biliary tract abnormality 0.5347723103329642 1.5360375477712631 0.1245291716724037 1.0 0.8211407869220101 24 P14174,P04062,Q10713,P09601,O43681,P07602,Q14739,P48506,Q5XKP0,Q14108,Q9NZJ7 11 +Abnormal protein o linked glycosylation 0.8460397892456935 1.5356624045048577 0.1246212002428788 1.0 0.8211407869220101 3 Q8N511 1 +Agitation 0.5319721826041611 1.5351956969980771 0.1247357649982661 1.0 0.8211407869220101 31 P04062,P48449,P10644,P05067,Q13501,P42892,O00592,P35637,Q92804 9 +Toe walking 0.5331901536820094 1.5338234229643448 0.125073098978949 1.0 0.8211407869220101 19 P50402,O43681,P07602,Q99720,P35637,Q9NZJ7 6 +Prominent superficial blood vessels 0.5872261632004045 1.5323390717389005 0.1254387841542206 1.0 0.8211407869220101 11 O75844 1 +Urinary bladder sphincter dysfunction 0.7227280435990808 1.532334829048223 0.1254398305776001 1.0 0.8211407869220101 6 Q9NR77,Q06787 2 +Opisthotonus 0.5332947450655784 1.5315288933101612 0.125638731153252 1.0 0.8211407869220101 20 P11117,P35637,Q99720,P07602 4 +Capillary hemangioma 0.7318722487891858 1.5312384295295771 0.1257104762548428 1.0 0.8211407869220101 5 Q9UHX1,Q9UBM7 2 +Neoplasm of the male external genitalia 0.695395041819812 1.5310139744644349 0.1257659389402061 1.0 0.8211407869220101 7 P10644,Q01844,P51809 3 +Back pain 0.5330752784705507 1.5301128439884617 0.1259887995655204 1.0 0.8211407869220101 20 Q8TAA9,P01889,P51798,P50402,Q969G3,P36551,P35670,Q12824 8 +Hypercholesterolemia 0.5858983370943317 1.524878945160861 0.1272892943418409 1.0 0.8211407869220101 11 Q8N511,Q15904 2 +Spastic paraparesis 0.531534628110049 1.5231992025309546 0.1277088755614717 1.0 0.8211407869220101 19 P04062,Q9H6K4,O75787,Q5XKP0,Q9Y619,Q8N0X7,Q6DKK2 7 +Gastrointestinal obstruction 0.5849153120134779 1.5193528607912303 0.1286737006730103 1.0 0.8211407869220101 11 P42892 1 +Depression 0.4238622509383822 1.5186780928889716 0.1288435434972286 1.0 0.8211407869220101 91 P50897,P06280,P07602,Q13501,P35637,Q6DKK2,Q06787,P01889,P21964,P10644,O00592,P35670,Q92804,P04062,Q96N66,O43681,Q9Y4P3,P50995,Q9NZJ7,O00754 20 +Weight loss 0.4753406195581729 1.5152630176293205 0.1297058098842887 1.0 0.8211407869220101 57 P38571,P04062,P01889,Q13423,P10644,P35670,P07602,Q06136,Q99720,O75844,Q01844,P42892,P35637,Q9NZ08 14 +Abnormality of adrenal physiology 0.5314978757508851 1.5147070391155284 0.129846611017939 1.0 0.8211407869220101 25 P38571,O00170,P33991,Q13423,P10644,Q99496,P51809,Q969G3,P16435,O75381,O95470,Q12824 12 +Abnormal oral mucosa morphology 0.4818641894479799 1.5146625943810983 0.1298578717326579 1.0 0.8211407869220101 55 P04062,P16278,P01889,P10644,P08236,O75845,Q15392,Q14739,Q02241,P53634,Q14108,Q9UBM7,O00754,Q9NZ08 14 +Hemangiomatosis 0.9447388342165024 1.5109259674550393 0.1308073139958663 1.0 0.8211407869220101 2 P48735 1 +Lymphangioma 0.9447388342165024 1.5109259674550393 0.1308073139958663 1.0 0.8211407869220101 2 P48735 1 +Visceral angiomatosis 0.9447388342165024 1.5109259674550393 0.1308073139958663 1.0 0.8211407869220101 2 P48735 1 +Abnormality of the parathyroid gland 0.5446127723206258 1.508141371405044 0.1315183486779123 1.0 0.8211407869220101 16 Q08J23,P21964,P10644,P40939,O75874,P35670,P48735 7 +Supernumerary tooth 0.716899996993676 1.507050357551525 0.1317977498799267 1.0 0.8211407869220101 6 Q9UBM7 1 +Hypomimic face 0.608923407849973 1.5047629670147793 0.1323850279544696 1.0 0.8211407869220101 10 O75787,P04062,P35270,O00592 4 +Abnormality of secondary sexual hair 0.6892786564333572 1.5031935888451038 0.1327891303080148 1.0 0.8211407869220101 7 Q14574 1 +Short middle phalanx of finger 0.8377224347786716 1.5021244874813229 0.1330649618550157 1.0 0.8211407869220101 3 Q9UHX1 1 +Generalized joint laxity 0.5812221225722434 1.498567809673526 0.1339857888851809 1.0 0.8211407869220101 11 Q9UHX1,Q9Y487 2 +Tritanomaly 0.8366185266333815 1.4976715585755604 0.1342186047850664 1.0 0.8211407869220101 3 O00429 1 +Anomalous trichromacy 0.8366185266333815 1.4976715585755604 0.1342186047850664 1.0 0.8211407869220101 3 O00429 1 +Anterior uveitis 0.8365692345446025 1.497472716795733 0.1342702995711953 1.0 0.8211407869220101 3 P01889 1 +Unilateral renal agenesis 0.5272072593056535 1.4953779922741657 0.1348158208342373 1.0 0.8211407869220101 19 Q2VPK5,P10644,Q86XL3,Q9UHX1,Q9UBM7 5 +Increased intracranial pressure 0.5345203381271084 1.494733099524344 0.1349841122593225 1.0 0.8211407869220101 17 P01889,P10644,P07602,Q969G3,Q9NZJ7,Q12824,Q9NZ08 7 +Vascular skin abnormality 0.4340709930960601 1.491227091680271 0.1359018831606784 1.0 0.8211407869220101 102 P07858,Q13126,P06280,Q8IZA0,Q14108,P16278,P01889,O00462,P21964,P10644,Q9NWM8,Q14739,O75844,Q9UBM7,P04062,P10619,Q16625,P04066,Q9Y487,O75306,Q8NCH0,Q06136 22 +Joint contracture of the hand 0.5193439285639864 1.489643997602227 0.1363178669147859 1.0 0.8211407869220101 37 Q15392,Q9NR77,Q8IZA0,O75844,P42892 5 +Episodic pain 0.6051263210941454 1.484559991466089 0.1376604203391147 1.0 0.8211407869220101 10 P23786,P07686 2 +Psoriasiform dermatitis 0.9379258137774404 1.4830257928167885 0.138067558082064 1.0 0.8211407869220101 2 P10321 1 +Short stepped shuffling gait 0.8329503110324087 1.4828724050747957 0.1381083143079484 1.0 0.8211407869220101 3 O00592 1 +Orthostatic hypotension 0.5635261740056382 1.482658782418783 0.1381650908311047 1.0 0.8211407869220101 13 P04062,O43681,P07602,P07686 4 +Abnormal pharynx morphology 0.5261005702367955 1.4810041514961785 0.1386054672201935 1.0 0.8211407869220101 27 Q13510,P16278,P08236,P15586,P54802 5 +Type ii transferrin isoform profile 0.9367903103709307 1.4783764761723177 0.139307038218821 1.0 0.8211407869220101 2 Q15904 1 +Abnormal femoral neck morphology 0.5236581608749868 1.4774781919405526 0.1395474998693233 1.0 0.8211407869220101 31 O95831,P16278,Q9Y487,O75844,P04066,O00754,Q9Y619,Q96A33,O75718 9 +Ambiguous genitalia male 0.934897804693413 1.4706281925372804 0.1413916952950109 1.0 0.8211407869220101 2 Q15392 1 +Diaphragmatic weakness 0.7530474075383708 1.4696318919427305 0.1416614779190668 1.0 0.8211407869220101 4 P10253 1 +Abdominal distention 0.5225358354336866 1.4692734774970264 0.1417586276147744 1.0 0.8211407869220101 18 P38571,P04062,O43681,P07602,Q01844 5 +Abnormal auditory evoked potentials 0.6266497863066146 1.4654432395608004 0.1428000276563588 1.0 0.8211407869220101 9 Q9NZJ7,P07602 2 +Diaphyseal thickening 0.828230442953408 1.4638258460261442 0.1432415385983851 1.0 0.8211407869220101 3 P08236 1 +Abnormal larynx morphology 0.5238006284635378 1.4633249024450463 0.143378496789297 1.0 0.8211407869220101 24 Q13510,P21964,P07602,Q14739,P16435,Q9UHX1 6 +Hand muscle weakness 0.6250525744529762 1.4573712647546526 0.1450139246633224 1.0 0.8211407869220101 9 Q13501,O95140,Q9NR77 3 +Abnormality of the clitoris 0.5515973371789351 1.4567984728757857 0.1451720175803825 1.0 0.8211407869220101 14 P53701,P51809,Q9H2M9,P16435,Q9Y619,Q9UBM7 6 +Abnormal saccadic eye movements 0.5217095644980511 1.4565202668608213 0.1452488511993486 1.0 0.8211407869220101 20 P04062,Q10713,O75306,O95140,Q8IV08,O14773 6 +Abnormal circulating acetylcarnitine concentration 0.7049592348912634 1.4551062281472915 0.145639855226529 1.0 0.8211407869220101 6 P23786,O43772 2 +Serositis 0.5279680693412621 1.4535056789194785 0.146083404093203 1.0 0.8211407869220101 17 Q9NQW6,P01889,Q9NZ08 3 +Heart block 0.5211908886121688 1.4531499632843028 0.146182121314208 1.0 0.8211407869220101 20 P50402,P23786,P06280,O43772 4 +Hyperhidrosis 0.5218440998379059 1.450833492552401 0.1468262309646901 1.0 0.8211407869220101 26 P07686,P04066,P01889,P07858 4 +Abnormal choroid plexus morphology 0.7130501656548695 1.4504204103144094 0.1469413188522002 1.0 0.8211407869220101 5 P53634 1 +Raynaud phenomenon 0.703809004716184 1.450093048250537 0.1470325734291178 1.0 0.8211407869220101 6 O75844 1 +Premature loss of primary teeth 0.8246905325760807 1.4495382098258718 0.1471873376691646 1.0 0.8211407869220101 3 P53634 1 +Abnormal morphology of the abdominal musculature 0.6232705196566666 1.4483593186182315 0.1475165859343159 1.0 0.8213120821667469 9 O00462 1 +Respiratory failure 0.4708865115309332 1.4468120886041054 0.1479495601142058 1.0 0.8213120821667469 56 Q13510,P07602,Q13501,Q9Y619,P35637,P61916,Q5XKP0,Q9BT22,Q92804,Q16637,Q15165,Q70HW3,P23786,P10253,O75306,P50995,P40939,Q9Y5P6,Q9NZJ7 19 +Mild short stature 0.8232014057709106 1.4435273259426702 0.1488719805045248 1.0 0.8231917947113274 3 Q14739 1 +Myelomeningocele 0.7463324327819842 1.441478817865542 0.1494494573343265 1.0 0.824542399125873 4 O75845 1 +Reduced visual acuity 0.4218466758882612 1.431344353418593 0.1523315481616887 1.0 0.8283425026487674 96 P50897,P07602,Q9NZ08,P06865,O96000,Q10713,P16278,P01889,Q9H061,O00429,Q9UHX1,O43681,Q9NPL8,P17900,O43505,Q9H6K4,Q15555,Q96CU9,O75306,O43676,Q07021,P07686 22 +Abnormality of skin adnexa physiology 0.5135726636756163 1.4306919109320324 0.1525185325653961 1.0 0.8283425026487674 35 P01889,P07858,P06280,P07686,P04066 5 +Neck muscle weakness 0.5545842158807609 1.430314725502683 0.1526267103149472 1.0 0.8283425026487674 13 Q99720,P07602 2 +Hyperactive deep tendon reflexes 0.5943130283868522 1.4268463529352382 0.153624186977678 1.0 0.8311048528547923 10 O75787,Q9NR77 2 +Submucous cleft of soft and hard palate 0.5163883767864348 1.425508879904997 0.1540101550847536 1.0 0.8311048528547923 19 O75844,O43505,Q15392 3 +Emg chronic denervation signs 0.5461822111528994 1.424482347399444 0.1543068915271506 1.0 0.8311048528547923 14 Q13510,O43681,P07602,O95140,P22626 5 +Hypoplasia of the frontal lobes 0.6715372326460793 1.4221803239855286 0.1549739092313822 1.0 0.8311048528547923 7 Q9UBM7 1 +Dysphagia 0.4377462399167736 1.4213431279403173 0.1552170313204246 1.0 0.8311048528547923 111 Q13510,P07602,P05067,Q13501,P15586,O75874,Q8IZA0,P35637,Q14108,Q06787,P01889,P61916,Q14739,Q9UHX1,Q15067,Q99720,Q9NR77,O15118,P48735 19 +Abnormal circulating estrogen level 0.5664480971102395 1.4150576978806024 0.1570515797660139 1.0 0.8311048528547923 11 Q969G3,P16435,Q12824,P51809 4 +Decreased activity of mitochondrial complex i 0.5160418567508447 1.4126256876920182 0.1577658119948104 1.0 0.8311048528547923 23 O96000,Q96CU9,O75306,O43676,Q9UBX3,Q70HW3 6 +Chorioretinal dysplasia 0.7383490001105788 1.4079775503785132 0.159137717661526 1.0 0.8311048528547923 4 P52732,O43505 2 +Chronic pulmonary obstruction 0.702556307352075 1.405213123766906 0.1599579127760577 1.0 0.8311048528547923 5 P21964,P06280 2 +Abnormal metabolic brain imaging by mrs 0.549784025816436 1.4021223168635804 0.1608787239281193 1.0 0.8311048528547923 13 O43819,O75306,O00429,P07602,Q9NZJ7 5 +Resting tremor 0.5197308655642519 1.401462703094774 0.1610757531415518 1.0 0.8311048528547923 17 P04062,Q9H6K4,O75787,P07602,O00592,Q9NZJ7,Q06787 7 +Esophageal varix 0.7361649824731744 1.398807788480869 0.1618706301122434 1.0 0.8311048528547923 4 P38571,P04062 2 +Heterogeneous 0.5078953979026994 1.3974159940817952 0.1622885122485946 1.0 0.8311048528547923 36 P12235,Q14126,P11717,Q16836,P01889,Q15555,P21964,P61916,Q9BQE5,P00367,P05067,Q9NR77,O75844,P53634,P07196,Q9Y619 16 +Slender long bone 0.63992384639617 1.3972624038667023 0.1623346770828364 1.0 0.8311048528547923 8 Q9Y619,Q9Y487 2 +Abnormality of salivation 0.49913847590346 1.3956545947493275 0.1628185335533143 1.0 0.8311048528547923 42 P01889,Q9Y5P4,O75787,P55011,P35670,Q15165,P50995,Q13501,Q14739,P15586,Q9NR77,P35637,Q92804,P55795 14 +Recurrent sinopulmonary infections 0.690777553227274 1.3931881962478536 0.1635628882332727 1.0 0.8311048528547923 6 Q9Y487 1 +Macular atrophy 0.6992993323507265 1.3911633400817685 0.1641759011890911 1.0 0.8311048528547923 5 P04439 1 +Drowsiness 0.6979142060281807 1.385185755446485 0.1659956751921232 1.0 0.8311048528547923 5 O00754 1 +Male sexual dysfunction 0.5864042104125012 1.3844741544774972 0.1662133166417225 1.0 0.8311048528547923 10 Q99496,Q969G3,P07686,O00592,Q12824,Q06787 6 +Abnormal atrioventricular conduction 0.5466921735806953 1.3839300130573602 0.1663798857238199 1.0 0.8311048528547923 13 P50402,P06280 2 +Cardiomegaly 0.5095509144125175 1.3788456049505011 0.1679423622966116 1.0 0.8311048528547923 31 P23786,P04062,P10253,P10644,Q07021,Q14739,P07686,P04066,P54802 9 +Steppage gait 0.5311130295562967 1.3783659912223178 0.1680903179707302 1.0 0.8311048528547923 15 O15270,P05023,O15269,Q13501,Q9NR77,P07196,P51149,O95140 8 +Abnormal prolactin level 0.6962950713276155 1.3781964779204026 0.1681426344006198 1.0 0.8311048528547923 5 Q969G3,P10644,Q12824 3 +Abnormality of the peritoneum 0.523370989522452 1.3766369449573543 0.1686245225406868 1.0 0.8311048528547923 16 Q01844 1 +Meningocele 0.6090496733054572 1.3762331780960677 0.1687494532864029 1.0 0.8311048528547923 9 Q8TAA9,Q10713,O75845 3 +Poor fine motor coordination 0.6958083413368661 1.3760950481216352 0.1687922084468613 1.0 0.8311048528547923 5 O95140,Q06787 2 +Abnormal femoral neck head morphology 0.5035238444438862 1.3738655509750377 0.1694834261048043 1.0 0.8311048528547923 37 P16278,Q9Y487,Q14739,O75844,P04066,Q9Y619,O00754 7 +Venous thrombosis 0.5449430166248038 1.3736267734039 0.1695575806856148 1.0 0.8311048528547923 13 O75874,P01889,P48735,Q9NZ08 4 +Abnormality of the posterior pituitary 0.6597096571732145 1.3679330703363284 0.1713330270723856 1.0 0.8311048528547923 7 Q9UHX1,Q969G3,Q12824,Q99496 4 +Dyschromatopsia 0.6846612518151269 1.3664157232624723 0.1718085164574039 1.0 0.8311048528547923 6 Q9H061,O00429 2 +Abnormal endocardium morphology 0.5291031641877041 1.366081713747402 0.1719133171469791 1.0 0.8311048528547923 15 P04062,P01889,P10644,P06280,Q9NZ08 5 +Osteolysis involving bones of the upper limbs 0.684245456387214 1.364594306144192 0.1723805953510304 1.0 0.8311048528547923 6 O75844 1 +Decreased calvarial ossification 0.7275711214764436 1.3627096246821029 0.1729740433147006 1.0 0.8311048528547923 4 O75844 1 +Abnormality of the axillary hair 0.6923540485940249 1.3611765273575316 0.1734579100957782 1.0 0.8311048528547923 5 Q14574 1 +Osteopetrosis 0.8027262400605972 1.3608725688781158 0.1735539636460767 1.0 0.8311048528547923 3 P51798,Q15392 2 +Young adult onset 0.5818984025522611 1.360276682013734 0.1737423844590746 1.0 0.8311048528547923 10 Q9NZJ7,O15118,P07602 3 +Astrocytoma 0.6919650435023866 1.3594959662747683 0.1739894798288652 1.0 0.8311048528547923 5 P48735 1 +Abnormal brain positron emission tomography 0.6829336074614366 1.3588465549025706 0.1741952174711203 1.0 0.8311048528547923 6 Q13501,Q969G3,Q12824 3 +Hemiparesis 0.5494139256302619 1.3580787449967215 0.1744386988499335 1.0 0.8311048528547923 12 P01889,O00429,Q99496,Q969G3,Q12824,Q9NZ08 6 +Laryngomalacia 0.5493494143218368 1.3577048515193484 0.1745573567449878 1.0 0.8311048528547923 12 P21964,P07602,P16435 3 +Somatic sensory dysfunction 0.3988065689493085 1.357545599354406 0.1746079149077219 1.0 0.8311048528547923 82 O95831,O15270,P06280,P07602,P05067,P07196,Q9Y619,Q9NZ08,Q06787,P01889,O15269,P54802,Q8IV08,O14773,Q9H6K4,Q8NCH0,P07686,Q9NR77,O95140,Q9NZJ7 20 +Flared iliac wing 0.726307363944214 1.3573994543141543 0.1746543215393723 1.0 0.8311048528547923 4 P16278 1 +Atlantoaxial abnormality 0.8015407010985478 1.35608778630033 0.1750712384643373 1.0 0.8311048528547923 3 Q9NWM8 1 +Progressive pulmonary function impairment 0.8012116622491494 1.3547598473874711 0.1754940832508955 1.0 0.8311048528547923 3 Q969G3,Q12824 2 +Neuralgia 0.8012116622491494 1.3547598473874711 0.1754940832508955 1.0 0.8311048528547923 3 Q969G3,Q12824 2 +Ear pain 0.8012116622491494 1.3547598473874711 0.1754940832508955 1.0 0.8311048528547923 3 Q969G3,Q12824 2 +Visual acuity test abnormality 0.8012116622491494 1.3547598473874711 0.1754940832508955 1.0 0.8311048528547923 3 Q969G3,Q12824 2 +Hypothalamic hypothyroidism 0.8012116622491494 1.3547598473874711 0.1754940832508955 1.0 0.8311048528547923 3 Q969G3,Q12824 2 +Intracranial meningioma 0.8012116622491494 1.3547598473874711 0.1754940832508955 1.0 0.8311048528547923 3 Q969G3,Q12824 2 +Brain stem compression 0.8012116622491494 1.3547598473874711 0.1754940832508955 1.0 0.8311048528547923 3 Q969G3,Q12824 2 +Transient global amnesia 0.8012116622491494 1.3547598473874711 0.1754940832508955 1.0 0.8311048528547923 3 Q969G3,Q12824 2 +Decreased circulating follicle stimulating hormone concentration 0.8012116622491494 1.3547598473874711 0.1754940832508955 1.0 0.8311048528547923 3 Q969G3,Q12824 2 +Decreased circulating gonadotropin concentration 0.8012116622491494 1.3547598473874711 0.1754940832508955 1.0 0.8311048528547923 3 Q969G3,Q12824 2 +Abnormality of the biliary system 0.4172209309191557 1.353848703625821 0.175784651746035 1.0 0.8311048528547923 98 Q13510,P07602,Q14108,Q10713,O75787,P21964,P61916,P10644,O75845,Q14739,Q5XKP0,P35670,Q9UBM7,P04062,O43681,Q9Y4P3,Q16625,P04066,P38571,O15118,Q15904 21 +Positive romberg sign 0.6810086722473329 1.3504095972000651 0.1768846340732597 1.0 0.8311048528547923 6 Q8IV08,Q9H6K4,O95140 3 +Alkalosis 0.6896854840450768 1.349645928171052 0.1771295844569631 1.0 0.8311048528547923 5 Q9Y619 1 +Abnormality of hepatobiliary system physiology 0.4240916162390794 1.3492631031343414 0.1772524724075141 1.0 0.8311048528547923 66 Q13510,P38571,P04062,O43772,Q10713,Q16836,P01889,P23786,O75787,O75306,Q8N511,O75845,Q16625,O15118,Q5XKP0,Q9Y619,P35670 17 +Anhidrosis 0.7243547977714964 1.349194263021167 0.1772745770188228 1.0 0.8311048528547923 4 P04066 1 +Ureteral duplication 0.688572315676893 1.3448346937934597 0.1786786236825155 1.0 0.8311048528547923 5 P23786,O75844 2 +Diminished movement 0.5326380254260362 1.343283812730572 0.179180091566846 1.0 0.8311048528547923 14 P12235,P04062,P51114,O00592 4 +Bilateral talipes equinovarus 0.679024533366361 1.341709477178368 0.1796902129481634 1.0 0.8311048528547923 6 O00754,Q15392 2 +Recurrent respiratory infections 0.4183784680350068 1.3413675514801642 0.1798011473791878 1.0 0.8311048528547923 100 Q13510,P10253,P16278,Q9Y487,P01889,P02786,O00462,P08236,P07602,P15586,P54802,P04066,P53634 13 +Depletion of mitochondrial dna in muscle tissue 0.7973129014903555 1.3390269785530533 0.180561890307862 1.0 0.8311048528547923 3 Q9UBX3 1 +Diabetes insipidus 0.545772793733804 1.3369599124220115 0.1812357225027179 1.0 0.8311048528547923 12 P06280 1 +Cardiac valve calcification 0.7214109492320213 1.3368220205154275 0.1812807394944466 1.0 0.8311048528547923 4 O75844 1 +Mitral valve calcification 0.7214109492320213 1.3368220205154275 0.1812807394944466 1.0 0.8311048528547923 4 O75844 1 +Myoclonus 0.3932198689261131 1.3352644028849174 0.1817898248870784 1.0 0.8311048528547923 79 Q13510,P04062,O75503,Q96CU9,P50897,O95630,O75845,P07602,P05067,Q9H2C2,Q9UBX3,Q9NQZ5,O00592,Q14108,O14773 15 +Postaxial hand polydactyly 0.5451525963942903 1.333359591239351 0.1824138264802564 1.0 0.8311048528547923 12 Q14739,Q9UBM7,O75845 3 +Postaxial polydactyly 0.5013074367168682 1.3322216417780983 0.182787366997678 1.0 0.8311048528547923 18 Q14739,Q2VPK5,Q9UBM7,O75845 4 +Nephropathy 0.5012716477618475 1.331989267678558 0.1828637152200556 1.0 0.8311048528547923 18 P06280 1 +Gastric ulcer 0.7943960620976908 1.3272590511607814 0.1844230045153092 1.0 0.8319245753592704 3 P04062,Q8N5K1 2 +Hyporeflexia 0.4076515043634749 1.3237423363874636 0.1855886328020777 1.0 0.8319245753592704 92 P12235,O95831,P11177,P07602,Q13501,P07196,P35637,Q06787,Q10713,O75787,O15269,P54802,O00592,O14979,P04062,Q16637,O43681,Q9H2C2,O43505,Q15067,Q99720,Q9NR77,O95140,Q9NZJ7 24 +Ulnar deviation of the hand or of fingers of the hand 0.5984039910102799 1.3220126155622958 0.18616395005587 1.0 0.8319245753592704 9 Q9UBM7 1 +Abnormal meningeal morphology 0.5003659053997855 1.3212549767713275 0.1864163607406836 1.0 0.8319245753592704 19 Q8TAA9,Q10713,O75845,Q9UHX1,Q15904 5 +Abnormal protein glycosylation 0.528763257343825 1.3199621674257824 0.1868476496183861 1.0 0.8319245753592704 14 Q8N511,Q15904,Q9Y487 3 +Gray matter heterotopia 0.5017111102568199 1.3193837868197789 0.1870408392810134 1.0 0.8319245753592704 22 Q86XL3,Q9UBM7,O43505,Q06787 4 +Abnormal bleeding 0.4048170869923483 1.3180332502496896 0.187492517434719 1.0 0.8319245753592704 90 P23786,P04062,Q9Y487,P01889,Q13126,P21964,Q8NCH0,Q9NWM8,P10644,P05067,P11117,Q14739,Q16625,O75844,Q02241,Q9UHX1,Q14108,Q9NZ08 18 +Abnormal blood transition element cation concentration 0.5425132681805258 1.3180279975950906 0.187494275721423 1.0 0.8319245753592704 12 P28288,Q9Y487,O43819,Q02241,P35670,Q15904,Q10567 7 +Premature loss of teeth 0.5421801707513052 1.3160919339206292 0.1881431879343302 1.0 0.8319245753592704 12 O75844 1 +Abnormal oral physiology 0.4674506901124703 1.3160246562796891 0.1881657671964833 1.0 0.8319245753592704 52 P01889,Q9Y5P4,O75787,P55011,P10644,P35670,Q15165,P50995,Q13501,Q14739,P15586,Q9NR77,Q02241,P35637,Q92804,P55795 16 +Genu valgum 0.5017132488776068 1.3158761255574103 0.1882156231417902 1.0 0.8319245753592704 28 Q9NR77,O00754,P08236,P16278 4 +Mitral stenosis 0.7906428819434017 1.3121208466479035 0.1894793631979991 1.0 0.8319245753592704 3 O75844 1 +Aortic valve calcification 0.7906428819434017 1.3121208466479035 0.1894793631979991 1.0 0.8319245753592704 3 O75844 1 +Agnosia 0.622243394300422 1.311827841185066 0.1895782288189282 1.0 0.8319245753592704 8 P05067 1 +Hydrocephalus 0.4319420833894234 1.3111451405177053 0.189808732482297 1.0 0.8319245753592704 63 P48651,Q99496,O96028,Q10713,Q08J23,P51798,P21964,P10644,Q9UBM7,P04062,Q15392,Q12824,O43505,Q8TAA9,P23786,P08236,Q969G3,Q9Y5P6,P16435,O95140,O00754 21 +Symptomatic seizures 0.6220330594960792 1.3108089852052165 0.1899223061310047 1.0 0.8319245753592704 8 Q13423,P00367,Q16836,P53985 4 +Abnormal pleura morphology 0.4987107078939991 1.310435096748058 0.1900486871234812 1.0 0.8319245753592704 19 P14174,P01889,P52732,P08236,Q8NCH0,Q14739,Q9NZ08 7 +Mixed demyelinating and axonal polyneuropathy 0.7898523286633878 1.3089328394384414 0.1905571014891056 1.0 0.833184510612565 3 P35670,P07196 2 +Intracranial hemorrhage 0.4992860451634745 1.3062668689237498 0.1914618197751996 1.0 0.8351417689717193 21 P23786,O75844,P05067 3 +Stillbirth 0.5400545390166834 1.3037312332418536 0.1923252362987482 1.0 0.8351417689717193 12 Q14739,P04062,O75844 3 +Synostosis involving digits 0.7129216335227553 1.3011375466449413 0.193211377858298 1.0 0.8351417689717193 4 P48651 1 +Abnormality of primary teeth 0.5252519480457676 1.2987947976270764 0.1940143604973154 1.0 0.8359356266559549 14 O75844 1 +Anencephaly 0.5251104745865646 1.2979412993432125 0.1943075069741497 1.0 0.8359356266559549 14 Q8TAA9,O43505 2 +Impaired tactile sensation 0.6690427666393488 1.29788831242362 0.1943257168178171 1.0 0.8359356266559549 6 Q9NR77,O15269 2 +Abnormal social behavior 0.4678005890534276 1.2971925627217984 0.1945649390685981 1.0 0.836163771633564 51 O96000,Q96CU9,O75306,O43676,O43681,P07602,P05067,Q15067,Q9Y4P3,Q5XKP0,Q9UHX1,O00592,Q5KU26,Q06787 14 +Acute hepatic failure 0.5454841252441239 1.2956452993603311 0.1950977149065882 1.0 0.8376518524335447 11 P38571,Q16836,P01889 3 +Azoospermia 0.6176646270319447 1.289636440290263 0.1971769172667405 1.0 0.8404926614097399 8 P04062,P51809 2 +Abnormality of adrenal morphology 0.4966888644245822 1.2890709510399323 0.1973734214001308 1.0 0.8404926614097399 21 P38571,P10644,O75874,O75844,P48735 5 +Joint stiffness 0.4715357141138848 1.2882218259936982 0.1976687564197947 1.0 0.8404926614097399 49 Q8TAA9,P16278,P01889,P50402,P08236,Q9Y4P3,P15586,O75874,O75844,P54802,P16435,P51648,O00754,P48735 14 +Increased bone mineral density 0.4972085158251064 1.286951625696823 0.1981111494892897 1.0 0.8404926614097399 23 P04062,Q13126,Q15392,Q13501,Q14739,P54802,Q14108 7 +Abnormal macular morphology 0.4960789849453295 1.2818811417873066 0.1998843442668296 1.0 0.8430195401663536 22 Q13510,P50897,P04439 3 +Entropion 0.6155787235481143 1.2795188681785563 0.2007143996062923 1.0 0.8430195401663536 8 O75844 1 +Negativism 0.8879636638909885 1.2789854764695288 0.2009021703297893 1.0 0.8430195401663536 2 Q9BQE5 1 +Social and occupational deterioration 0.8879636638909885 1.2789854764695288 0.2009021703297893 1.0 0.8430195401663536 2 Q9BQE5 1 +Bacterial endocarditis 0.8875851627554874 1.2774463962886198 0.201444693585272 1.0 0.8430195401663536 2 P04062 1 +Inverted nipples 0.6728114428456811 1.276642797461083 0.2017283850872331 1.0 0.8430195401663536 5 P61978,Q9BV10,Q15067 3 +Decreased muscle mass 0.5144532428955348 1.2761996962876716 0.2018849359844836 1.0 0.8430195401663536 15 Q8TAA9,P04066,Q9Y487 3 +Decreased plasma carnitine 0.5893837844377121 1.27593581755309 0.2019782083475301 1.0 0.8430195401663536 9 P23786,O43772 2 +Abducens palsy 0.7811435062476513 1.2738312257617712 0.2027232361748672 1.0 0.8445800151363868 3 Q9NZJ7,P07602 2 +Movement abnormality of the tongue 0.7063838599064821 1.2736552106908707 0.2027856363059874 1.0 0.8445800151363868 4 P10253 1 +Elevated circulating follicle stimulating hormone level 0.7062166498137665 1.2729523607750275 0.2030349472211474 1.0 0.8445800151363868 4 P51809 1 +Acute coronary syndrome 0.4917395636356828 1.269951997256384 0.204101729616696 1.0 0.8445800151363868 18 P06280,P01889,O75844,Q9NZ08 4 +Scrotal hypoplasia 0.5126620488771406 1.2651711535590957 0.205809980698687 1.0 0.8457973492667729 15 Q15555,Q9H2M9,Q9BV10,P16435,P18074,Q9UBM7,P46977 7 +Mutism 0.5194348098789349 1.2636603996913347 0.2063519444564479 1.0 0.8457973492667729 14 Q13510,P35637,Q13501 3 +Abnormality of the tongue 0.3832992158662726 1.26347684330666 0.2064178635220848 1.0 0.8457973492667729 76 Q13510,O95831,P48651,Q99496,P07196,O60828,Q10713,P01889,P16278,O75844,P61978,Q9UBM7,P51114,O00170,Q16637,Q9Y4P3,P04066,Q96A33,Q12824,P10253,Q9NVV4,Q969G3,P07686,Q9Y5P6,O00754 25 +Abnormal cardiac ventricular function 0.5193196975582219 1.262964332724578 0.206601998098834 1.0 0.8457973492667729 14 O75844 1 +Abnormal ilium morphology 0.504986714650431 1.2616896096084504 0.207060497170354 1.0 0.8457973492667729 16 O00754,P16278,P01889 3 +Memory impairment 0.4908874590434007 1.260176442732719 0.2076057189558253 1.0 0.8457973492667729 34 P01889,Q12824,O43681,P00403,P07602,Q99496,Q13501,P05067,Q969G3,Q9NZJ7,Q9NZ08,Q06787 12 +Muscle stiffness 0.4906915553130052 1.2578909313612423 0.2084312038262352 1.0 0.8457973492667729 19 P23786,Q15392,P07602,O00592 4 +Abnormality of the shoulder girdle musculature 0.4931323472578502 1.2564405960429843 0.2089562708307883 1.0 0.8457973492667729 28 P12235,O14979,Q9Y487,P50402,O00429,P07602,Q13501,Q9NZJ7 8 +Increased serum pyruvate 0.4928901393959695 1.254645991041608 0.2096073000113958 1.0 0.8457973492667729 25 O96000,Q96CU9,O75306,O43676,Q5JRX3,Q9NPL8,Q70HW3,Q9BWD1 8 +Abnormal length of corpus callosum 0.8819076457229371 1.2543780298655451 0.2097046342253921 1.0 0.8457973492667729 2 P11177 1 +Postaxial foot polydactyly 0.6103468466338118 1.2541211367101626 0.2097979788141424 1.0 0.8457973492667729 8 Q14739,Q9UBM7,O75845 3 +Abnormality of the 5th toe 0.6103468466338118 1.2541211367101626 0.2097979788141424 1.0 0.8457973492667729 8 Q14739,Q9UBM7,O75845 3 +Psychosis 0.4927817249027208 1.2539080633146444 0.209875423893072 1.0 0.8457973492667729 25 O76024,P10644,P61916,Q5JRX3,P00403,Q13501,P48506,P36551,O15118,Q8N0X7,Q6DKK2 11 +Abnormal cartilage morphology 0.562115472816487 1.253593576492403 0.209989767186028 1.0 0.8457973492667729 10 O75874,P48735 2 +Atrioventricular canal defect 0.6581888429034131 1.2501510015079849 0.2112443919647721 1.0 0.847118829879731 6 Q9UBM7 1 +Axial dystonia 0.7745769266614556 1.2473905272976342 0.2122543381972645 1.0 0.847118829879731 3 Q99720 1 +Orthostatic hypotension due to autonomic dysfunction 0.5837809961153481 1.24726010472589 0.2123021407076422 1.0 0.847118829879731 9 P04062,O43681,P07602 3 +Abnormal retinal vascular morphology 0.4728637106340039 1.247064184578832 0.2123739640197097 1.0 0.847118829879731 46 Q13510,P16278,Q15555,P10619,P21964,O75306,P07602,P04439,Q9Y4P3,P07686,P17900,P06865 12 +Abnormal heart sound 0.6996606437714552 1.2453982151756529 0.212985409055384 1.0 0.847118829879731 4 P10253 1 +Abnormal brain n acetyl aspartate level by mrs 0.7734288210751992 1.2427704002612987 0.2139524529349163 1.0 0.847118829879731 3 P07602 1 +Abnormal brain choline level by mrs 0.7734288210751992 1.2427704002612987 0.2139524529349163 1.0 0.847118829879731 3 P07602 1 +Reduced brain n acetyl aspartate level by mrs 0.7734288210751992 1.2427704002612987 0.2139524529349163 1.0 0.847118829879731 3 P07602 1 +Temperature instability 0.6319448968251085 1.2399797905228709 0.2149828692143345 1.0 0.847403362453676 7 P35270,P07602 2 +Abnormality of the nasolabial region 0.6642864263019048 1.239716637526476 0.2150802211339546 1.0 0.847403362453676 5 Q9Y487 1 +Prominent nasolabial fold 0.6642864263019048 1.239716637526476 0.2150802211339546 1.0 0.847403362453676 5 Q9Y487 1 +Recurrent aspiration pneumonia 0.6558030649347654 1.2396476985758775 0.2151057299481609 1.0 0.847403362453676 6 Q13510 1 +Abnormality of ocular smooth pursuit 0.4868654961469876 1.232752151782372 0.2176682479698435 1.0 0.852265127840076 19 P11177,O14773,O00754,Q06787 4 +Thin ribs 0.5276921008889688 1.2316523120759224 0.218078990770747 1.0 0.8527200092952963 12 Q9Y619,O75844,Q32P28 3 +Abnormality of the calcaneus 0.6298741235022312 1.2304091814777112 0.2185439168779528 1.0 0.8527200092952963 7 O75787 1 +Central apnea 0.6294600988195374 1.2284952949411576 0.2192610945519635 1.0 0.8527723902038206 7 Q8N5K1,Q10713,Q9NZJ7,P07602 4 +Limitation of joint mobility 0.3861228109232076 1.2263001263675333 0.2200857538265048 1.0 0.8528085594778544 81 Q8TAA9,P23786,O14979,P16278,P01889,Q9H6K4,P50402,P08236,Q9Y4P3,P15586,O75874,O75844,P54802,P16435,P51648,O00754,P48735 17 +Hepatomegaly 0.4516260053639674 1.2231663076793593 0.2212668883233501 1.0 0.8537024015980804 142 Q13510,P07602,P15586,Q01844,Q9Y619,Q14108,P16278,O75787,P61916,O75845,Q14739,P54802,P04062,Q16625,P04066,O43772,P28070,P38571,P23786,P10253,Q96CU9,O75306,O43676,P08236,Q15067,P07686,O15118,Q15904,O00754 29 +Slow saccadic eye movements 0.5562716344500085 1.2219576081687216 0.2217236583695088 1.0 0.8543340776114975 10 Q8IV08 1 +Fractures of the long bones 0.6939068163309569 1.221223769865716 0.2220013067407298 1.0 0.8543340776114975 4 Q13501,Q13126 2 +Cutaneous photosensitivity 0.4847607507487652 1.21890500262409 0.222880250721998 1.0 0.855499803127908 19 Q14108,Q9UBM7 2 +Hip pain 0.6594199445386427 1.2186300747627252 0.2229846288585109 1.0 0.855499803127908 5 O75844 1 +Exostoses 0.6929195734620368 1.217076984829594 0.2235749264586006 1.0 0.8559889128095273 4 P48735 1 +Epispadias 0.7667550170390149 1.2159329807146362 0.2240104532250795 1.0 0.8565717528995093 3 Q9Y619,P48651 2 +Mesomelia 0.6266281429905665 1.2154010795030032 0.2242131565119196 1.0 0.8565717528995093 7 Q9UBM7 1 +Abnormal circulating fatty acid anion concentration 0.5547885065047237 1.2139209288415131 0.2247779200761108 1.0 0.857670041683784 10 P23786,O43772 2 +Enlarged ovaries 0.7648879072184598 1.2084310297528758 0.2268815102291981 1.0 0.8620345705916486 3 P10644 1 +Abnormality of the wrist 0.4850705423421491 1.2053184637904686 0.2280803844399705 1.0 0.8630003159140016 23 Q13510,P16278,Q9H6K4,Q9BV10,O75844,P16435 6 +Retinal thinning 0.8697956093868267 1.2052905664889226 0.2280911500750684 1.0 0.8630003159140016 2 P04439 1 +Elevated circulating alanine aminotransferase concentration 0.6003003297817033 1.205276707178855 0.2280964985504163 1.0 0.8630003159140016 8 P10253,Q15904 2 +Bilateral coxa valga 0.8694171082513225 1.203759628249082 0.2286824979064066 1.0 0.8641654986647838 2 O00754 1 +Macrovesicular hepatic steatosis 0.7632072683918426 1.2016808631130935 0.229487198314946 1.0 0.8643815788383291 3 P23786 1 +Mask like facies 0.5523777350108479 1.2008513639514065 0.2298088633117267 1.0 0.8643815788383291 10 O75787,Q06787 2 +Recurrent hand flapping 0.8682816048448128 1.199168005790642 0.2304626251084247 1.0 0.8647844981105767 2 Q06787 1 +Biliary tract neoplasm 0.688164506509968 1.1971094383858851 0.2312639016323319 1.0 0.8647844981105767 4 O43681,P07602 2 +Neoplasm of the gallbladder 0.688164506509968 1.1971094383858851 0.2312639016323319 1.0 0.8647844981105767 4 O43681,P07602 2 +Vegetative state 0.688164506509968 1.1971094383858851 0.2312639016323319 1.0 0.8647844981105767 4 O43681,P07602 2 +Progressive peripheral neuropathy 0.688164506509968 1.1971094383858851 0.2312639016323319 1.0 0.8647844981105767 4 O43681,P07602 2 +Foot dorsiflexor weakness 0.4838302071290564 1.1945739270872968 0.2322535410862614 1.0 0.8649917717292952 24 O15270,P05023,O15269,Q13501,Q14739,Q99720,Q9NR77,P07196,P51149,O95140 10 +Inappropriate behavior 0.5011835644175838 1.1943155239245924 0.2323545673539144 1.0 0.8649917717292952 15 Q13501,P17900,P35670,P07602 4 +Prolonged neonatal jaundice 0.4941562242124559 1.1935458823723823 0.2326556540607209 1.0 0.8649917717292952 16 P61916,O15118 2 +Wormian bones 0.4940733682570017 1.193023482928141 0.2328601763573186 1.0 0.8649917717292952 16 O75844,Q9Y487,Q32P28 3 +Hand polydactyly 0.4839503887159998 1.1922431974650176 0.2331658999332591 1.0 0.8654116170250138 27 Q10713,O75845,Q15067,Q14739,Q9UHX1,Q9UBM7 6 +Facial hypotonia 0.5498817006584058 1.1873117930164772 0.2351046581038072 1.0 0.8684568511162759 10 P10253 1 +Upper airway obstruction 0.6855468242074703 1.186121693167438 0.2355742447570774 1.0 0.8684568511162759 4 O75844 1 +Pleural effusion 0.5262232508253726 1.185139953177914 0.2359621165816721 1.0 0.8684568511162759 11 P14174,P52732,P01889,Q14739,Q9NZ08 5 +Neoplasm of the pituitary gland 0.5064484028628055 1.1849504730422586 0.2360370295309692 1.0 0.8684568511162759 14 P10644,Q99496,Q969G3,O75874,P48735,Q12824 6 +Rimmed vacuoles 0.5061121681729498 1.1829079781875804 0.2368456193927581 1.0 0.8684568511162759 14 P50402,O14979,Q13501 3 +Ketotic hypoglycemia 0.8637395912187733 1.180819984854181 0.2376742431826746 1.0 0.8702345947890591 2 P53985 1 +Infection related seizure 0.4976684747984491 1.1725591194235994 0.2409726512412486 1.0 0.8720452673041481 15 P05067 1 +Abnormal glycosylation 0.4767789566904745 1.172042107129947 0.2411801511584477 1.0 0.8720934451309087 18 Q8N511,Q15904,Q9Y487 3 +Distal upper limb amyotrophy 0.5688914777163084 1.1708797278885816 0.2416471246913616 1.0 0.8721311682713216 9 Q13501,Q9NR77 2 +Shuffling gait 0.5232757233803816 1.168174472842526 0.2427363951138992 1.0 0.8721311682713216 11 O75844,O00592 2 +Follicular hyperkeratosis 0.6476020960615216 1.1674171375308358 0.2430419536103967 1.0 0.8721311682713216 5 Q14574 1 +Abnormal paranasal sinus morphology 0.4899385828390376 1.1669346799307188 0.2432367494222831 1.0 0.8721311682713216 16 P28070,O00754,P04066,Q06787 4 +Long toe 0.5921876307325311 1.1657751158669027 0.2437053806667413 1.0 0.8721311682713216 8 Q9UHX1,P23786 2 +Recurrent pharyngitis 0.8599545798637376 1.1655536770957498 0.2437949459721475 1.0 0.8721311682713216 2 P01889 1 +Aplasia hypoplasia of the patella 0.6470422553768269 1.164991262440228 0.2440225296730367 1.0 0.8721311682713216 5 Q9Y619 1 +Fulminant hepatic failure 0.7536611436526344 1.1633904129695318 0.2446711374722732 1.0 0.8721311682713216 3 Q16836 1 +Facial capillary hemangioma 0.8584405753217226 1.1594534958795693 0.2462713818395236 1.0 0.8721311682713216 2 Q9UBM7 1 +Pericarditis 0.6790052117778518 1.158680184105819 0.2465865710047023 1.0 0.8721311682713216 4 P01889,Q9NZ08 2 +Stroke 0.4787616074294427 1.1581702074131426 0.2467945837197802 1.0 0.8721311682713216 25 P06280,P05067 2 +Abnormal labia minora morphology 0.6453873707562507 1.157820693314984 0.246937216850823 1.0 0.8721311682713216 5 Q9Y619,P16435 2 +Thickened skin 0.3801680309211982 1.1576139729612136 0.2470216044843083 1.0 0.8721311682713216 81 Q14126,P04062,P16278,P50402,P51648,O15269,P06280,Q9NWM8,Q06136,Q14739,O75844,P04066,P53634,P28070,P48449,O95470,Q14574 17 +Pituitary hypothyroidism 0.6367738764581601 1.1557785155492062 0.2477717630419165 1.0 0.8721311682713216 6 Q969G3,Q12824,Q99496 3 +Calvarial hyperostosis 0.677560307016436 1.1526226710688836 0.2490652936750292 1.0 0.8737108448340786 4 P22626 1 +Thickened calvaria 0.5652676800470592 1.1522586984096972 0.2492147833962268 1.0 0.8737108448340786 9 P16278 1 +Proximal tubulopathy 0.4806306822399717 1.1515545818497872 0.2495041539647682 1.0 0.8740430229764228 17 O96000,Q96CU9,O43676,O75306 4 +Hyperesthesia 0.8561695685087015 1.150310277055399 0.250016099475268 1.0 0.8744721983983089 2 P07602 1 +Bilateral tonic clonic seizure with focal onset 0.8561695685087015 1.150310277055399 0.250016099475268 1.0 0.8744721983983089 2 P07602 1 +Abnormal acetabulum morphology 0.4939001903599604 1.1492083386565772 0.2504700832774347 1.0 0.8749145735701479 15 P08236,P16278 2 +Diplopia 0.4868626466480709 1.1475031944782323 0.2511737136300009 1.0 0.8749145735701479 16 O14773,P01889,O00592 3 +Visual loss 0.4621930618592826 1.1464465952090066 0.2516104124465208 1.0 0.8749145735701479 45 O75503,P50897,P07602,Q99496,Q8TC12,Q10713,P01889,P51798,O00429,P00403,P04439,P48449,O14773,O00170,Q12824,P52732,O75306,Q969G3,P40939,O95140,Q9NZJ7 21 +Metaphyseal cupping 0.8542770628311865 1.1426975736575984 0.2531641775539617 1.0 0.8749145735701479 2 Q14739 1 +Prominent sternum 0.8542770628311849 1.142697573657592 0.2531641775539643 1.0 0.8749145735701479 2 P16278 1 +Recurrent fever 0.4992757742032119 1.1413348942031143 0.2537305865126733 1.0 0.8749145735701479 14 P28070,Q9NR77 2 +Fetal akinesia sequence 0.6747085832629279 1.140671811000794 0.25400652136721 1.0 0.8749145735701479 4 P04062 1 +Fever 0.3875767697570954 1.1390680891169689 0.2546747559689986 1.0 0.8749145735701479 70 Q13510,P38571,P23786,P10253,P01889,P06280,P07602,Q14739,Q9NR77,Q9NQW6,P28070,Q9NZ08 12 +Trophic changes related to pain 0.8531415594246778 1.1381329258508344 0.2550649812557055 1.0 0.8749145735701479 2 O15269 1 +Impaired distal tactile sensation 0.8531415594246778 1.1381329258508344 0.2550649812557055 1.0 0.8749145735701479 2 O15269 1 +Emg slow motor conduction 0.8531415594246778 1.1381329258508344 0.2550649812557055 1.0 0.8749145735701479 2 O15269 1 +Penetrating foot ulcers 0.8531415594246778 1.1381329258508344 0.2550649812557055 1.0 0.8749145735701479 2 O15269 1 +Ankylosis 0.6400448588176801 1.1346758637653347 0.2565111537949112 1.0 0.8771655034373651 5 O75844,P16435 2 +Abnormal enchondral ossification 0.4745740599368276 1.1343757681923503 0.2566369590649271 1.0 0.8771655034373651 23 Q9Y619,Q14739,Q9UBM7,P08236 4 +Abnormality of the knee 0.3742000279279291 1.1341738887874522 0.2567216145131474 1.0 0.8771655034373651 73 Q13510,P23786,O95831,P16278,P51798,P21964,P48651,P08236,O75477,Q15041,Q9Y4P3,P37268,Q86XL3,Q9Y5P6,Q9NR77,Q9Y619,Q8N0X7,O00754 18 +Abnormality of the tarsal bones 0.4732720021276397 1.1331093292344732 0.2571683440905559 1.0 0.8771655034373651 21 O75787,Q14739,O75844 3 +Optic disc pallor 0.4665440532646729 1.1326401653208622 0.2573653942389666 1.0 0.8771655034373651 41 O96000,O95831,Q10713,Q9H6K4,Q96CU9,O75306,O43676,Q9H061,O00429,P04439,Q6P4Q7,Q9NPL8,O95140,O00754 14 +Toxemia of pregnancy 0.6726663792789027 1.132117373023779 0.257585091839948 1.0 0.8771655034373651 4 Q14739 1 +Areflexia 0.3950352180830592 1.131786739849163 0.2577241038658466 1.0 0.8771655034373651 68 Q13510,P12235,O95831,Q13501,P07196,O75787,O15269,O00429,O75477,Q15041,Q9BT22,P51114,Q16637,O43505,P10253,Q9H6K4,P05023,Q15067,P40939,Q9Y5P6,Q9NR77,P51149,O95140 23 +Brain imaging abnormality 0.475207568597893 1.1314869684954283 0.2578501852612178 1.0 0.8771655034373651 28 O43819,O75306,O00429,P07602,Q99496,Q13501,Q969G3,Q9BV10,Q9BT22,Q9NZJ7,Q12824 11 +Paralysis 0.4618167598302616 1.1300662216026869 0.2584483216542612 1.0 0.8771655034373651 44 P04062,P10253,P51798,P50402,P50995,O95140,Q13501,Q9NR77,P36551,P35637,Q92804,P17900 12 +Abnormality of chorioretinal pigmentation 0.7452434974699358 1.1297091954677316 0.2585987812404968 1.0 0.8771655034373651 3 Q9Y619 1 +Abnormal epidermal morphology 0.4839572199515466 1.1291315356115923 0.2588423498535781 1.0 0.877329051465977 16 O75844,Q14574,Q06136 3 +Limited extraocular movements 0.6378740990929143 1.125274085575086 0.2604729075150089 1.0 0.8789233126916886 5 O43819,O75306,Q9BVA1 3 +Abnormal arachnoid mater morphology 0.6068175341898667 1.12368654831156 0.2611460250024358 1.0 0.8789233126916886 7 Q15904 1 +Migraine 0.4717692330180374 1.1230503566871954 0.2614161082203123 1.0 0.8789233126916886 21 P12235,P01889,Q12824,O00429,P00403,P05067,Q9NQZ5,Q9NZ08 8 +Abnormal thyroid stimulating hormone level 0.8493565480696437 1.122934069295186 0.2614654967170109 1.0 0.8789233126916886 2 P10644 1 +Abnormal systemic arterial morphology 0.4130027033025903 1.1193532200594103 0.26298947961837 1.0 0.882065536195743 113 Q13510,P07602,P05067,Q06787,P06865,P16278,P01889,P61916,Q9NWM8,O75845,O75844,Q9UHX1,Q9UBM7,P04062,P10619,P17900,P10253,P07686,O15118 19 +Ectrodactyly 0.5018867767176175 1.1178072286214182 0.2636493335561898 1.0 0.8836187738812301 13 Q99720,P48449,Q9NR77,Q9UBM7 4 +Leukoencephalopathy 0.3721179027930569 1.1102792149402865 0.266878726854622 1.0 0.8859014407298113 73 O96000,O75503,O00584,Q96CU9,O75306,P11177,O00429,O43681,P07602,O43676,Q9NPL8,Q9UHX1,Q9NZJ7,P17900 14 +Horizontal nystagmus 0.4701913724879371 1.1082674577980252 0.2677463251707621 1.0 0.8859014407298113 22 P04062,Q9H061,O00429,P07602,O14773,Q9NZJ7 6 +3 methylglutaconic aciduria 0.5803281585101769 1.107963469458112 0.2678775927793297 1.0 0.8859014407298113 8 Q3ZCQ8,Q9H6K4,Q5XKP0 3 +Synostosis of metacarpals metatarsals 0.7396958798769742 1.107561215554158 0.2680513611894342 1.0 0.8859014407298113 3 P16435 1 +Emotional lability 0.4476019266951656 1.1066266176933806 0.2684553941769123 1.0 0.8859014407298113 50 P07602,Q99496,Q13501,P09651,P35637,P10644,Q92804,O00170,O43681,Q15165,Q8N0X7,Q12824,Q9NVV4,Q96CU9,O75306,P43243,P50995,Q9Y276,Q969G3,Q9NZJ7 20 +Congenital hypothyroidism 0.6658203560950448 1.1034674808509777 0.2698242060092932 1.0 0.8859014407298113 4 P10644 1 +Muscle fiber atrophy 0.4662681203261687 1.102913455904463 0.2700647501863142 1.0 0.8859014407298113 18 P50402,P23786,P35637,Q99720 4 +Acne 0.5117052108933219 1.1014667253678598 0.2706935787434144 1.0 0.8859014407298113 11 Q92542,P01889,Q9NZ08 3 +Limb joint contracture 0.3788285277484611 1.100878126966112 0.2709497029259262 1.0 0.8859014407298113 84 P23786,Q15392,Q99720,Q86XL3,Q9NR77,Q8IZA0,O75844,P42892,Q9Y619,P35637 10 +Abnormality of the nasal bone 0.7377363024608219 1.0997482685118296 0.2714418175839799 1.0 0.8859014407298113 3 P10644 1 +Sclerocornea 0.5546617726120823 1.0977087522161406 0.2723316867632082 1.0 0.8859014407298113 9 O96028,P53701,O75569,Q6NUK1,Q9UBM7 5 +Abnormal tongue morphology 0.4231264055996032 1.0976228921906714 0.2723691924240825 1.0 0.8859014407298113 59 P10253,P16278,P07686,O75844,P04066,Q9UBM7,O00754 7 +Increased circulating antibody level 0.5046985162966194 1.096872153920076 0.2726972829854084 1.0 0.8859014407298113 12 P28070,Q14108 2 +Abnormality of the pharynx 0.4677941014627448 1.0965092042425626 0.2728559975854259 1.0 0.8859014407298113 35 Q13510,P16278,P08236,P15586,P54802 5 +Deep plantar creases 0.6310863485152401 1.0958880988783652 0.2731277478894844 1.0 0.8859014407298113 5 P61978,Q9Y487 2 +Decreased number of peripheral myelinated nerve fibers 0.5106008048000377 1.0950916434914528 0.2734764893127623 1.0 0.8859014407298113 11 O15269,Q9NR77,P07196,P51149,O95140 5 +Neonatal hypoglycemia 0.5999320584959353 1.0917830148382093 0.2749284864423831 1.0 0.8859014407298113 7 Q16836,O43772 2 +Abnormal liver physiology 0.6299037048065856 1.0907704507590803 0.2753739018231655 1.0 0.8859014407298113 5 Q13510 1 +Abnormal mitochondrial morphology 0.5527894881499558 1.0880729161633205 0.2765629190962331 1.0 0.8859014407298113 9 Q13501 1 +Respiratory arrest 0.6290430921817902 1.0870468285930508 0.2770161146827414 1.0 0.8859014407298113 5 P23786 1 +Abnormal atrioventricular valve physiology 0.4618309790175948 1.0866089792586022 0.2772096550425127 1.0 0.8859014407298113 40 P04062,P01889,O75306,P10644,P06280,O75844,Q15904,O00754,Q9NZ08 9 +Opsoclonus 0.8398940196820568 1.0850565816207534 0.2778965958513928 1.0 0.8859014407298113 2 P04062 1 +Saccadic oscillation 0.8398940196820568 1.0850565816207534 0.2778965958513928 1.0 0.8859014407298113 2 P04062 1 +Hip osteoarthritis 0.8398940196820565 1.0850565816207525 0.2778965958513932 1.0 0.8859014407298113 2 P01889 1 +Dry hair 0.7339055470503439 1.0844915031040132 0.2781469323425238 1.0 0.8859014407298113 3 O60828 1 +Temporal pattern 0.6281107074983081 1.0830131692347855 0.2788025777259562 1.0 0.8859014407298113 5 Q9NR77 1 +Abnormal mitral valve physiology 0.4673812188054184 1.0817808958792874 0.2793498973694324 1.0 0.8859014407298113 32 P04062,P01889,O75306,P06280,O75844,O00754,Q9NZ08 7 +Urinary incontinence 0.4622481978785686 1.0812363640857596 0.2795919861503255 1.0 0.8859014407298113 39 Q8TAA9,O43681,P07602,Q99496,Q13501,Q10471,Q99720,Q969G3,P07686,P07196,P35637,Q9NZJ7,Q12824,Q06787 14 +Red eye 0.4762771718352018 1.0804956739823368 0.2799215121639025 1.0 0.8859014407298113 16 P02786,Q14739,P28070,P01889 4 +Cirrhosis 0.466953863535801 1.0786945815974451 0.2807239019361029 1.0 0.8859014407298113 32 P11717,P04062,P38571,Q10713,O75787,Q14739,Q14108,Q15904 8 +Hypertensive crisis 0.6597844516990956 1.0782472976619364 0.2809234095619388 1.0 0.8859014407298113 4 P01889 1 +Upper limb spasticity 0.596913319477975 1.07779514847174 0.2811251851162182 1.0 0.8859014407298113 7 Q99720 1 +Aplasia hypoplasia of the sacrum 0.7320662982846207 1.0771745040200047 0.2814023133261998 1.0 0.8859014407298113 3 P04066 1 +Dystrophic toenail 0.6578402634314825 1.070132688962298 0.2845595870131778 1.0 0.8859014407298113 4 Q969G3,O75844 2 +Pain 0.4490276532175143 1.0688048406134367 0.2851576176990906 1.0 0.8859014407298113 154 Q13510,P12235,P06280,P07602,Q13501,O75874,Q01844,P42892,P35637,Q14108,P22626,Q9NZ08,Q06787,P01889,P21964,P10644,O15269,O00429,O75477,Q14739,O75844,P35670,Q92804,P04062,P50402,Q9Y4P3,Q9NQW6,P28070,Q70HW3,Q8TAA9,P23786,Q9H6K4,Q13423,P50995,P07686,Q9NR77,O95140,O75569,Q9NZJ7,P48735 40 +Fatiguable weakness of proximal limb muscles 0.6575156149254355 1.0687781299742751 0.2851696562368548 1.0 0.8859014407298113 4 Q92734 1 +Hyperconvex nail 0.5722425316908434 1.0685230384675903 0.2852846437961758 1.0 0.8859014407298113 8 P42892 1 +Proximal muscle weakness in lower limbs 0.4806571008952923 1.0669523636774385 0.2859933473860614 1.0 0.8859014407298113 15 P12235,P50402,Q16637,P35670,P07196,O95140 6 +Soft skin 0.571911255743627 1.0669069619958516 0.2860138507371059 1.0 0.8859014407298113 8 Q9NWM8,O00754 2 +Lissencephaly 0.4486213552930712 1.0650283072445386 0.286863120102949 1.0 0.8859014407298113 47 P23786,Q2VPK5,Q9Y487,Q15392,Q96EK5,Q16625,Q86XL3,O43505 8 +Abnormal z disc morphology 0.7289483433225592 1.064783217494793 0.2869740414067696 1.0 0.8859014407298113 3 Q13501 1 +Abnormal sarcomere morphology 0.7289483433225592 1.064783217494793 0.2869740414067696 1.0 0.8859014407298113 3 Q13501 1 +Wide cranial sutures 0.593995968539356 1.064277689557183 0.2872029217640524 1.0 0.8859014407298113 7 O75844 1 +Cardiovascular calcification 0.5701310794270066 1.0582226334300262 0.2899539549197514 1.0 0.8859014407298113 8 O75844 1 +Abnormal aortic arch morphology 0.5919408872913382 1.054756272925305 0.2915368079290577 1.0 0.8859014407298113 7 Q9UHX1 1 +Excessive daytime somnolence 0.5036146192722941 1.0547402379999276 0.291544143468009 1.0 0.8859014407298113 11 Q969G3,Q9UBM7,Q12824,Q99496 4 +Dysmetria 0.4521941408975198 1.0532334000130434 0.2922340342073897 1.0 0.8859014407298113 44 Q10713,O75503,O75787,Q5JRX3,Q13501,Q9Y4P3,Q8IV08,O14773,Q6DKK2,Q06787 10 +Bowing of the arm 0.6535903696992768 1.0524112114221733 0.2926109271008006 1.0 0.8859014407298113 4 Q32P28 1 +Proximal symphalangism 0.7254833569318888 1.0510324245524356 0.29324369809374 1.0 0.8859014407298113 3 P48651 1 +Symphalangism affecting the phalanges of the hand 0.7254833569318888 1.0510324245524356 0.29324369809374 1.0 0.8859014407298113 3 P48651 1 +Incoordination 0.4178217147429521 1.0476993584844891 0.2947771432321748 1.0 0.8867007034532467 59 Q13510,P04062,Q10713,O75503,O75787,O43681,P07602,Q15067,Q13501,O95140,Q9NR77,O00754,Q9Y619,P35670,O14773,Q9NZJ7,Q6DKK2 17 +Impairment of activities of daily living 0.4403353001425334 1.044969627601738 0.2960370072184277 1.0 0.8881110216552832 50 Q8TAA9,O15270,P21964,O15269,O43681,P07602,Q99496,Q13501,Q10471,Q99720,Q969G3,P07686,P07196,P35637,Q9NZJ7,Q12824,Q06787 17 +Abnormal tongue physiology 0.4767125952896537 1.04240434631585 0.2972242522744199 1.0 0.8910775146624967 15 Q13510,O95831,P10253,Q16637,P51114 5 +Generalized muscle weakness 0.462237416768334 1.0405053914297582 0.2981051605371863 1.0 0.8919989970880634 28 P12235,O95831,P10253,Q15165,P50995,Q13501,P35637,Q92804 8 +Spastic diplegia 0.4594573540367077 1.0404573352346298 0.2981274759806687 1.0 0.8919989970880634 21 Q99720,P51648,P35637,P07602 4 +Lower limb spasticity 0.3974278065503684 1.039505594038428 0.2985696577640488 1.0 0.8927272523424391 65 P04062,Q9H6K4,O75787,Q96CU9,O75306,O00429,O75477,P07602,Q15041,Q99720,O00754,Q5XKP0,Q9Y619,P35637,Q9NZJ7,Q6DKK2 16 +Cholestasis 0.4098320987679689 1.0298266117359276 0.3030914060688685 1.0 0.8978354970266507 61 Q13510,P38571,O75787,P10644,P61916,O75845,Q14739,Q16625,O15118,Q9UBM7,Q15904 11 +Abnormality of skin physiology 0.3667277154757376 1.0290061294308583 0.3034767945861625 1.0 0.8978354970266507 79 P38571,P01889,P07858,P48449,P02786,P21964,Q8NCH0,Q06136,Q14739,P53634,P10321,P28070,Q92542,P35670,Q9UBM7,Q9NZ08 16 +Action tremor 0.4382997522302738 1.0276565721701223 0.3041114028053522 1.0 0.899120678076917 50 Q14108,Q9H6K4,O75787,O75306,Q5JRX3,O43681,P07602,O95140,Q99720,Q9NR77,P35637,O75569,O14773,Q9NZJ7,Q06787 15 +Abnormal peripheral action potential amplitude 0.606667103983408 1.0230088535777038 0.306303659749817 1.0 0.8997140333649261 6 Q92734,O15269,O15270 3 +Progressive spasticity 0.4733149193304345 1.0212459657449846 0.3071379196542083 1.0 0.8997140333649261 15 P17900,O43681,P07602 3 +Abnormal left ventricle morphology 0.4580110937580609 1.0155202589450183 0.3098578944570735 1.0 0.8997140333649261 25 P12235,O75208,O00170,P10253,O75787,P06280,P00403,Q07021,P40939,Q7L0Y3 10 +Recurrent bacterial infections 0.4786348915559629 1.0154036747454005 0.3099134420897877 1.0 0.8997140333649261 14 Q15904,P53634 2 +Decreased facial expression 0.4578822893573243 1.0146319952100378 0.3102812818465128 1.0 0.8997140333649261 25 P04062,O75787,P35270,O00592,Q06787 5 +Infectious encephalitis 0.6044707734934447 1.0133338497043316 0.3109007243940553 1.0 0.8997140333649261 6 Q14739,P01889 2 +Slowly progressive 0.4403404159167666 1.0116899717709786 0.3116863118493267 1.0 0.8997140333649261 48 P12235,O95831,O14979,O00584,O75787,P50402,Q16637,O00429,O95140,Q99720,Q9NR77,P07196,Q8IV08,O14773 14 +Short femur 0.6040396614477372 1.0114351059587396 0.3118082259181363 1.0 0.8997140333649261 6 Q9UHX1,Q9BV10 2 +Gait ataxia 0.4077401593983014 1.0095584946573664 0.3127068633835259 1.0 0.8997140333649261 61 Q8IV08,P07602,Q13501,Q9NR77,O15118,Q14108,O14773,O00754,Q06787 9 +Abnormal circulating fatty acid concentration 0.4776294742890846 1.0092584082567164 0.3128507213360398 1.0 0.8997140333649261 14 P23786,O43772 2 +Varicose veins 0.6431606554524509 1.0090300029785355 0.3129602453926741 1.0 0.8997140333649261 4 P04062 1 +Venous insufficiency 0.6431606554524509 1.0090300029785355 0.3129602453926741 1.0 0.8997140333649261 4 P04062 1 +Ovarian neoplasm 0.4650066463191657 1.0089662749048325 0.3129908085479684 1.0 0.8997140333649261 16 O75874,Q01844,P48735 3 +Skeletal muscle hypertrophy 0.4537250876929187 1.008845444253874 0.313048762752234 1.0 0.8997140333649261 38 P10253,Q10713,P16278,Q9Y4P3,P07686,Q9NR77,P04066,O00754 8 +Impaired social interactions 0.4559299959873563 1.008701842073437 0.3131176480903848 1.0 0.8997140333649261 35 O96000,Q96CU9,O75306,O43676,Q15067,O00592,Q9UHX1,Q5KU26,Q5XKP0,Q06787 10 +Coxa vara 0.5164603455731026 1.005500468009123 0.3146559242274747 1.0 0.8997140333649261 10 O75718,O95831,Q9Y487 3 +Abnormal shape of the frontal region 0.3682137064575357 1.004751031249795 0.3150167487302198 1.0 0.8997140333649261 82 Q9Y487,P16278,Q15067,Q15392,P15586,P04066,Q9Y619,O00754,Q06787 9 +Abnormal urine cytology 0.4563609544817559 1.0045718490265056 0.3151030582271816 1.0 0.8997140333649261 33 P04062,Q14108,P06280,P01889 4 +Multiple enchondromatosis 0.6098609687275656 1.0041989545450385 0.3152827259423176 1.0 0.8997140333649261 5 P48735 1 +Gonadal neoplasm 0.4521616562676759 1.0030850092231611 0.3158198469291089 1.0 0.8997140333649261 19 P10644,P51809,O75874,Q01844,P48735 5 +Aplasia hypoplasia involving the sinuses 0.6413055692514139 1.001332178112545 0.3166662410817125 1.0 0.8997140333649261 4 P04066 1 +Impaired proprioception 0.4566630851617582 1.0009760536180523 0.3168383855814489 1.0 0.8997140333649261 29 Q9NR77,P54802,Q9Y619,Q8IV08,O14773 5 +Pituitary adenoma 0.5156226083672133 1.0009370911375646 0.3168572231040127 1.0 0.8997140333649261 10 O75874,P48735 2 +Positional foot deformity 0.3654071215670231 0.9996039401025114 0.3175022156199705 1.0 0.8997140333649261 80 Q8TAA9,Q2VPK5,Q9Y487,P21964,P08236,Q9NWM8,O75845,Q8NCH0,Q15392,Q9NR77,Q9BV10,Q9Y619,Q96A33,Q9UBM7,O00754,Q9UHX1 16 +Variable expressivity 0.3898131368076117 0.9977756180171826 0.3183881757428539 1.0 0.8997140333649261 66 Q13510,Q6P4A7,P52732,Q9H061,O00429,P07602,P35270,Q9NZJ7,Q9NR77,P07196,Q70HW3,P17900,O95140,O95470,Q12824 15 +Thin skin 0.453769338906757 0.9973071417933912 0.3186154482105101 1.0 0.8997140333649261 22 Q9Y619,Q13126,O75844,Q06787 4 +Reduced circulating prolactin concentration 0.6403262744949116 0.997270929516042 0.3186330203409924 1.0 0.8997140333649261 4 Q969G3,Q12824 2 +Joint swelling 0.5573876877414787 0.996069689444072 0.3192162858431993 1.0 0.8997140333649261 8 Q13510,P14174,P35670 3 +Absent hypoplastic paranasal sinuses 0.7114234445272614 0.9954719593954532 0.3195067755398899 1.0 0.8997140333649261 3 P04066 1 +Abnormality of the musculature of the upper arm 0.6078292014126931 0.9954449184819364 0.3195199211902135 1.0 0.8997140333649261 5 O14979 1 +Proximal upper limb amyotrophy 0.6078292014126931 0.9954449184819364 0.3195199211902135 1.0 0.8997140333649261 5 O14979 1 +Abnormality of temperature regulation 0.3718812315358767 0.992847847397073 0.3207841084495233 1.0 0.8997140333649261 86 Q13510,P23786,P38571,P10253,P01889,P10644,P06280,P07602,P35270,Q14739,Q9NR77,Q9NQW6,O43772,P28070,Q9NZ08 15 +Limited wrist movement 0.6379259057873001 0.9873236029692418 0.3234840232943743 1.0 0.9029992937926016 4 O75844 1 +Progressive visual loss 0.4511369003986235 0.9844902033696494 0.3248745459528799 1.0 0.9029992937926016 21 O75503,O75306,P50897,O00429,Q99496,Q969G3,O95140,O14773,Q12824 9 +Premature skin wrinkling 0.4611118933105124 0.9842163944317568 0.3250091265823343 1.0 0.9029992937926016 16 O75844 1 +Decreased testicular size 0.4481798486266465 0.9834604356084252 0.3253808784247394 1.0 0.9029992937926016 18 Q06787,O43505 2 +Quadriceps muscle weakness 0.7077482139460283 0.9810178710628348 0.3265839287774288 1.0 0.9029992937926016 3 O95140 1 +Abnormal middle phalanx morphology of the hand 0.5538943816089557 0.9790420088237928 0.3275592232593394 1.0 0.9029992937926016 8 Q9UHX1,P48651,Q03164 3 +Hyperthyroidism 0.5755042907284096 0.9786582903323346 0.3277488474231607 1.0 0.9029992937926016 7 P21964,Q06787 2 +Abnormal optical coherence tomography 0.8130204390613142 0.9785954481695436 0.3277799092490838 1.0 0.9029992937926016 2 P04439 1 +Photoreceptor layer loss on macular oct 0.8130204390613142 0.9785954481695436 0.3277799092490838 1.0 0.9029992937926016 2 P04439 1 +Osteopenia 0.4043916647092717 0.9770622613755762 0.3285383295574853 1.0 0.9029992937926016 61 P04062,Q9Y487,Q13126,P10644,Q9NWM8,P07602,Q32P28,O75844,O00754,Q14108,O75718 11 +Abnormal temper tantrums 0.5308654477887969 0.9752065772741644 0.3294578002159065 1.0 0.9029992937926016 9 Q06787 1 +Increased c peptide level 0.8118849356548048 0.9741390919397898 0.3299874818228634 1.0 0.9029992937926016 2 Q16836 1 +Type ii lissencephaly 0.8115064345192993 0.9726544809270202 0.3307250555581567 1.0 0.9029992937926016 2 O43505 1 +Adducted thumb 0.450712953695454 0.9721770864888212 0.3309624576947918 1.0 0.9029992937926016 23 Q86XL3,Q8NCH0,P42892 3 +Prenatal maternal abnormality 0.5103129616778859 0.9720159218418328 0.3310426276911897 1.0 0.9029992937926016 10 Q8TAA9,Q14739,O43772,P16435 4 +Ankyloblepharon 0.7054400946136266 0.9719565109876848 0.3310721842886823 1.0 0.9029992937926016 3 O75569 1 +Abnormal umbilicus morphology 0.4373251330537603 0.9717798915249708 0.331160061651395 1.0 0.9029992937926016 47 Q9Y487,P21964,P08236,Q9NWM8,Q8NCH0,Q9Y4P3,Q14739,O75844,O00754 9 +Vertigo 0.449902972553884 0.9711201230410474 0.3314884641807345 1.0 0.903346294075048 22 P06280,P01889,Q9NZ08 3 +Talipes equinovarus 0.3906294870436961 0.9698969606874372 0.3320978551857134 1.0 0.9044581368338624 65 Q8TAA9,Q2VPK5,Q9Y487,P21964,P08236,Q9NWM8,O75845,Q8NCH0,Q15392,Q9BV10,Q9NR77,Q9Y619,Q96A33,O00754 14 +Onion bulb formation 0.5943098484221307 0.9686177175711989 0.3327359600379744 1.0 0.9056467857760868 6 O95140,Q9NR77 2 +Personality changes 0.4709099310116597 0.968173379071465 0.3329577876009262 1.0 0.9057016499792608 14 Q13501,P04062 2 +Abnormal ureter morphology 0.4584295992086593 0.9671648830859516 0.3334616142445168 1.0 0.906362846411495 16 P23786,O75844 2 +Abnormal corneal epithelium morphology 0.4640624125746831 0.9635818690290991 0.3352556004868094 1.0 0.9064617108887788 15 P01889,Q14739,Q96EK5,O75844,Q9NZ08 5 +Brittle hair 0.4691459759440871 0.9573853643855542 0.3383727828352354 1.0 0.9071506165099342 14 O75844 1 +Retinal coloboma 0.5912035980100042 0.9549653034830876 0.3395952434171119 1.0 0.9071506165099342 6 Q9UHX1 1 +Pituitary growth hormone cell adenoma 0.7005020526805029 0.9526142410628086 0.3407855590163953 1.0 0.9071506165099342 3 P10644 1 +Recurrent skin infections 0.4682534028873736 0.9519263408877136 0.3411343396002908 1.0 0.9071506165099342 14 P02786,P53634 2 +Pulmonary infiltrates 0.5691973040134534 0.949503127051224 0.3423647823477034 1.0 0.9071506165099342 7 Q13510,P04062,P01889 3 +Delayed menarche 0.5897611666877183 0.948628921528768 0.3428093761157873 1.0 0.9071506165099342 6 O75844 1 +Abnormal male reproductive system physiology 0.449071363015344 0.947772781345892 0.3432451399119882 1.0 0.9071506165099342 31 O76024,P04062,Q13423,Q99496,P51809,Q9Y4P3,Q969G3,P07686,O00592,Q8N5K1,P16435,Q12824,Q06787 13 +Retinal degeneration 0.4307241591276279 0.9466268821411052 0.3438289407072126 1.0 0.9071506165099342 49 Q13510,P04062,O75503,P50897,P04439,O14773,O00754 7 +Pain in head and neck region 0.5964365706808779 0.946460319565584 0.3439138520189835 1.0 0.9071506165099342 5 Q969G3,Q12824 2 +Abnormal response to endocrine stimulation test 0.6988253704047869 0.9460608088624372 0.3441175716468185 1.0 0.9071506165099342 3 Q13423 1 +Lymphedema 0.4672762819862524 0.94595011936966 0.3441740283707895 1.0 0.9071506165099342 14 P08236,P06280 2 +Muscle fiber inclusion bodies 0.5251281169260154 0.945690308196802 0.3443065672217948 1.0 0.9071506165099342 9 O43676,Q9Y5P6,O75340,P07196,P09651 5 +Hypergonadotropic hypogonadism 0.4842001269783554 0.942490021289982 0.3459418176268414 1.0 0.9071506165099342 11 Q16740,P51809 2 +Pleuritis 0.6975791286969939 0.9411945805966364 0.346605153461258 1.0 0.9071506165099342 3 P01889 1 +Neuroinflammation 0.6975791286969939 0.9411945805966364 0.346605153461258 1.0 0.9071506165099342 3 P01889 1 +Pulmonary embolism 0.6975791286969939 0.9411945805966364 0.346605153461258 1.0 0.9071506165099342 3 P01889 1 +Orchitis 0.6975791286969939 0.9411945805966364 0.346605153461258 1.0 0.9071506165099342 3 P01889 1 +Increased ldl cholesterol concentration 0.546086164634638 0.9410106657911 0.3466993934132518 1.0 0.9071506165099342 8 P50402,Q8N511 2 +Hyperlipoproteinemia 0.546086164634638 0.9410106657911 0.3466993934132518 1.0 0.9071506165099342 8 P50402,Q8N511 2 +Bulbar signs 0.477971632176414 0.9395480544412776 0.3474494320436001 1.0 0.9071506165099342 12 P04062,O43681,P07602,Q99720,P35637 5 +Humeroradial synostosis 0.8024224072672206 0.9371549733520104 0.3486788471479973 1.0 0.9071506165099342 2 P16435 1 +Elbow ankylosis 0.8024224072672206 0.9371549733520104 0.3486788471479973 1.0 0.9071506165099342 2 P16435 1 +Aplastic clavicle 0.802422407267218 0.937154973352 0.3486788471480027 1.0 0.9071506165099342 2 Q9Y619 1 +Mild postnatal growth retardation 0.8016654049962132 0.9342084727560136 0.3501963660296185 1.0 0.9071506165099342 2 P10644 1 +Enchondroma 0.5445423555857873 0.9334972047907736 0.3505633129939389 1.0 0.9071506165099342 8 P48735 1 +Abnormal lower limb bone morphology 0.4181333138408725 0.9333630594439408 0.3506325466173081 1.0 0.9071506165099342 134 Q13510,P06280,P07602,Q9Y619,Q06787,Q10713,P16278,O75787,P21964,P10644,O75845,Q14739,O75844,Q9UHX1,Q9UBM7,P04062,Q15392,Q32P28,P04066,Q96A33,O75718,O43505,Q9Y487,Q9Y5P4,P08236,Q9NZJ7,Q9BV10,Q03164,P16435,O00754 30 +Redundant neck skin 0.5654897680772196 0.9323816671295352 0.3511393157353666 1.0 0.9071506165099342 7 Q9Y487 1 +Peripheral hypermyelination 0.6939485043714444 0.9270419704669224 0.3539047434167242 1.0 0.9071506165099342 3 Q9NR77 1 +Hepatic failure 0.4426248517287445 0.9243205008802496 0.3553194720750032 1.0 0.9071506165099342 38 Q13510,P38571,P04062,P23786,Q10713,Q16836,P01889,O75845,O15118,O43772,Q9Y619 11 +Spinocerebellar tract degeneration 0.7990158970476868 0.9239106478743604 0.3555328388049636 1.0 0.9071506165099342 2 O00754 1 +Abnormality of the spinocerebellar tracts 0.7990158970476868 0.9239106478743604 0.3555328388049636 1.0 0.9071506165099342 2 O00754 1 +Abnormal circulating proline concentration 0.7982588947766822 0.9209727393587804 0.3570646597587721 1.0 0.9071506165099342 2 O96000 1 +Decreased activity of the pyruvate dehydrogenase complex 0.4449429363231403 0.9205836441986792 0.3572678446478936 1.0 0.9071506165099342 17 Q96CU9,O75306 2 +Abnormal heart valve morphology 0.3857689835417728 0.9199426073136038 0.3576027518660392 1.0 0.9071506165099342 65 P04062,P16278,P01889,P21964,P10644,P08236,P06280,Q8NCH0,Q9Y4P3,O75844,Q9UHX1,Q06787 12 +Hypertrophic cardiomyopathy 0.370191011831342 0.9192474726110496 0.3579661455476342 1.0 0.9071506165099342 90 O96000,P12235,P10253,P16278,P01889,Q16836,P50402,Q96CU9,O43676,Q9H061,P06280,O75306,Q13423,Q9Y4P3,P15586,Q9NPL8,P54802,Q5XKP0 18 +Poor wound healing 0.5827534649251134 0.917878865472052 0.3586822874265092 1.0 0.9071506165099342 6 P04062,O15269,O15270 3 +Photophobia 0.444507260801447 0.916014022377332 0.3596595402860647 1.0 0.9071506165099342 32 P01889,Q15555,P51648,P07602,Q96S66,P04439,Q6P4Q7,P40939,P48449,P18074,Q9NZJ7,Q9NZ08 12 +Aplasia hypoplasia of the palmar creases 0.796744890234668 0.9151027907794868 0.3601376700328944 1.0 0.9071506165099342 2 Q8NCH0 1 +Sparse lateral eyebrow 0.5887190522273276 0.9133933265205064 0.3610357141296023 1.0 0.9071506165099342 5 Q08J23,O60828 2 +Bilateral ptosis 0.4779557925826104 0.9063950571241371 0.3647267881030287 1.0 0.9071506165099342 11 O75306,Q9Y5P4 2 +Abnormality of bone mineral density 0.3943831872100511 0.9063831540964864 0.3647330860949136 1.0 0.9071506165099342 113 Q13510,P12235,Q13126,P06280,P07602,Q13501,Q14108,P16278,P10644,Q9NWM8,O75845,Q14739,O75844,P54802,P35670,P04062,Q15392,Q32P28,Q9Y4P3,O75718,Q9Y487,P51809,Q9NZJ7,O00754 24 +Abnormality of the umbilical cord 0.5796613305140917 0.9043303406671866 0.3658202631211231 1.0 0.9071506165099342 6 O75844 1 +Abnormal circulating androgen level 0.4717423496089696 0.902868647751927 0.3665956120679707 1.0 0.9071506165099342 12 Q13423,P51809,Q969G3,P16435,Q12824 5 +Biliary cirrhosis 0.5585732243911588 0.9004829662654501 0.3678632861560271 1.0 0.9071506165099342 7 P09601,Q14739,P14174 3 +Abnormality of exocrine pancreas physiology 0.4594882446070067 0.8983205586570358 0.3690146752018748 1.0 0.9071506165099342 14 P14174,P09601,Q9Y3E5,Q9UHX1,Q15904 5 +Butterfly vertebrae 0.6144550320944865 0.8906977821832671 0.3730913249277483 1.0 0.9071506165099342 4 O75845 1 +Bowing of the legs 0.4343339384331789 0.8899256401257158 0.3735058152872488 1.0 0.9071506165099342 42 P16278,Q13126,P08236,Q32P28,Q9Y4P3,Q9NR77,O00754,P16435,Q9Y619,O75718 10 +Abnormality of the calf 0.4217016220331593 0.8859046655302083 0.3756689018272796 1.0 0.9071506165099342 50 O95831,P16278,Q13126,P08236,Q32P28,Q9Y4P3,Q9BV10,Q9NR77,O00754,P16435,Q9Y619,O75718 12 +Biparietal narrowing 0.513448289881649 0.8856852353529898 0.3757871666514512 1.0 0.9071506165099342 9 Q9UBM7,O75845 2 +Macular purpura 0.4513682831486544 0.8844297914279519 0.3764642468626664 1.0 0.9071506165099342 15 P04062,Q8NCH0,P10644,Q16625 4 +Hemivertebrae 0.4916263345197782 0.870348582500017 0.3841099366402938 1.0 0.9148543534967556 10 Q9Y619,Q9UHX1 2 +Excessive salivation 0.4378183472723066 0.8702883961392951 0.3841428187019762 1.0 0.9148543534967556 27 P01889,Q9Y5P4,O75787,P15586,Q9NR77,P35670 6 +Spastic paraparetic gait 0.6089794646385517 0.8683533264358244 0.3852009374629728 1.0 0.9148543534967556 4 O75787 1 +Exercise induced muscle cramps 0.5780838580599793 0.8680141835743879 0.3853865680427892 1.0 0.9148543534967556 5 P23786 1 +Oculomotor nerve palsy 0.5780711109312298 0.8679599409522752 0.3854162629293836 1.0 0.9148543534967556 5 Q969G3,Q12824,Q99496 3 +Arterial thrombosis 0.5778115765287218 0.8668556312629417 0.3860211163836122 1.0 0.915806039978237 5 P01889 1 +Abnormal aortic valve physiology 0.4365996086341435 0.8620930042089658 0.3886363407762134 1.0 0.9174642352352744 34 P04062,P16278,P01889,O75844,Q9UHX1,O00754,Q9NZ08 7 +Abnormal elasticity of skin 0.4059857163337957 0.8620216707854136 0.3886755927688927 1.0 0.9174642352352744 56 O96000,P04062,Q9Y487,Q15555,O75787,Q13126,P10644,Q8NCH0,Q9NWM8,Q9Y4P3,O75844,Q9UHX1,Q15904,O00754 14 +Broad palm 0.6073246546671942 0.8616175318563604 0.3888980201865555 1.0 0.9174642352352744 4 Q14739,P10644 2 +Proximal muscle weakness in upper limbs 0.4700906598738131 0.8609728328674188 0.3892530058739123 1.0 0.9174642352352744 11 P50402,O95140,P36551,P07196 4 +Abnormality of upper limb joint 0.367351325770314 0.8594219150091023 0.3901077832545698 1.0 0.9174642352352744 92 Q13510,O95831,P48651,Q96AY3,Q9Y3E5,Q8IZA0,P42892,Q9Y619,P07196,Q99567,O60828,P16278,P10644,O75844,P50402,Q15392,Q9Y4P3,P37268,P23786,Q9H6K4,Q9NR77,Q9BV10,Q03164,P16435 24 +Increased circulating prolactin concentration 0.5496094360432469 0.8592425189736995 0.3902067296820992 1.0 0.9174642352352744 7 Q969G3,Q12824,Q99496 3 +Proximal amyotrophy 0.4697066554238207 0.8587568365868901 0.3904746858211187 1.0 0.9174642352352744 11 P50402,O14979,Q16637,P35637 4 +Abnormal peripheral nervous system physiology 0.4279266216303234 0.8581434732486714 0.3908132446231296 1.0 0.9174642352352744 44 O95831,O15270,O15269,O43681,P07602,Q99720,Q9NR77,Q9NQZ5,P07196,Q9Y619,O95140,Q9NZJ7 12 +Restrictive ventilatory defect 0.4893627348434685 0.8580565880558917 0.3908612171475893 1.0 0.9174642352352744 10 P16278 1 +Hypersomnia 0.7808478425435257 0.853971022882362 0.3931210451743374 1.0 0.917794336777322 2 O95551 1 +Pituitary prolactin cell adenoma 0.7808478425435251 0.8539710228823596 0.3931210451743387 1.0 0.917794336777322 2 P10644 1 +Elevated circulating growth hormone concentration 0.7808478425435251 0.8539710228823596 0.3931210451743387 1.0 0.917794336777322 2 P10644 1 +Hepatitis 0.4519776259793129 0.8524141329817921 0.3939842787320669 1.0 0.917794336777322 14 P11717,P08236 2 +Petechiae 0.4878964039727882 0.8500978803757674 0.3952706699789496 1.0 0.917794336777322 10 P04062,P10644,Q16625 3 +Hyperextensible skin 0.4572222553316657 0.8500148573867546 0.3953168260396129 1.0 0.917794336777322 13 Q9UHX1,P04062,Q9NWM8 3 +Cortical cataract 0.6739643906946331 0.8498498507892585 0.3954085699948422 1.0 0.917794336777322 3 Q9H6K4 1 +Neurofibromas 0.5737165678958797 0.849452824149589 0.3956293702188156 1.0 0.917794336777322 5 Q969G3,Q12824 2 +Ventricular tachycardia 0.4680120616831836 0.8489800150144186 0.3958924128641112 1.0 0.917794336777322 11 P23786,Q14126,O43772 3 +Abnormal bone structure 0.4237593458203222 0.8454821896093604 0.397841672634722 1.0 0.917794336777322 148 Q13510,P12235,Q13126,P06280,P07602,Q13501,O75874,Q9Y619,Q14108,P22626,P16278,P10644,Q9NWM8,O75845,Q14739,O75844,P54802,P35670,Q9UBM7,P04062,Q15392,Q32P28,Q9Y4P3,P53634,O75718,Q9Y487,P08236,P51809,Q86XL3,Q9NZJ7,Q9BV10,O00754,P48735 33 +Overgrowth 0.7785768357305052 0.8453178799113329 0.3979333807696088 1.0 0.917794336777322 2 P61978 1 +Asymmetry of the ears 0.7763058289174826 0.8366860741999755 0.4027690488520237 1.0 0.9198433391881876 2 Q9UHX1 1 +Corticospinal tract hypoplasia 0.7759273277819803 0.8352495467382455 0.4035772181200705 1.0 0.9203274446930568 2 P11177 1 +Abnormal sharpey fiber morphology 0.5700552852660754 0.8339288170244783 0.4043210973902029 1.0 0.9203274446930568 5 P01889 1 +Exercise induced muscle stiffness 0.7751703255109734 0.8323783170118023 0.4051954370529611 1.0 0.9212971722630002 2 P53985 1 +Decreased circulating androgen concentration 0.5028999665849652 0.8316430969427431 0.4056104283712578 1.0 0.9212971722630002 9 Q969G3,P16435,Q12824,P51809 4 +Mortality aging 0.3615024943674083 0.8308142827204734 0.4060785527852923 1.0 0.9212971722630002 89 O96000,P38571,P04062,P16278,O00429,Q15067,P07602,P05067,Q14739,P07686,Q9Y4P3,O75844,Q9NPL8,P16435,Q15904,O75718,P51114 17 +Microretrognathia 0.4484009450787076 0.8305708924880036 0.4062160838214639 1.0 0.9212971722630002 14 Q9UHX1,Q16625 2 +Abnormal vitreous humor morphology 0.543316332318231 0.8303719481745302 0.4063285207254243 1.0 0.9212971722630002 7 P04439,Q99496 2 +Akinesia 0.5021388973450749 0.8277511892395111 0.4078114226994731 1.0 0.921346405251886 9 P04062,O00592 2 +Progressive external ophthalmoplegia 0.5620902457376631 0.8276342637473225 0.4078776576273655 1.0 0.921346405251886 6 Q07021,P12235 2 +Clonus 0.4321983370315891 0.8271429532002739 0.4081560409705194 1.0 0.921346405251886 29 Q9Y619,P35637,Q99720,P07602 4 +Male reproductive system neoplasm 0.4834724934252917 0.8261072593254926 0.4087432500805519 1.0 0.921694026635407 10 P10644,Q01844,P51809 3 +Erythema 0.4252337957733434 0.8237753921161842 0.4100671922839829 1.0 0.9217752121470816 19 P07858,Q06136 2 +Elevated gamma glutamyltransferase level 0.5974968021837811 0.8217908188087948 0.4111959599849721 1.0 0.9223716564950368 4 P38571 1 +Focal dystonia 0.4233799725398108 0.8192474386743014 0.4126452542105199 1.0 0.9223716564950368 18 Q99720,Q9NQZ5 2 +Pharyngitis 0.6656629213687548 0.8181832247468731 0.4132525724546987 1.0 0.9223716564950368 3 P01889 1 +Abnormality of the gallbladder 0.4297515723921856 0.8172100064978123 0.4138084250368143 1.0 0.9223716564950368 36 P04062,P21964,O43681,O75845,P07602,Q9Y4P3,P04066,Q96A33,Q9UBM7 9 +Neuropathic arthropathy 0.6652951177233908 0.8167862290353256 0.4140506033164093 1.0 0.9223716564950368 3 O15269 1 +Dermatological manifestations of systemic disorders 0.3905121354995079 0.814269429161377 0.4154906189096703 1.0 0.9247589377665884 60 P38571,O75787,P10644,P61916,Q14739,Q16625,O75844,P04066,O15118,O43772,Q15904 11 +Encephalopathy 0.3473100741423372 0.8140098842174692 0.4156392885756605 1.0 0.9247589377665884 78 O96000,P23786,P04062,Q16836,Q96CU9,O75306,O43676,O00429,Q15067,P07602,Q9H2C2,O43772,Q9Y619,Q5KU26 14 +Self mutilation 0.5586070244940936 0.8125014513285759 0.4165039541333371 1.0 0.9255414438460252 6 Q9UBM7 1 +Iris coloboma 0.4289881861007863 0.80837520507008 0.4188746211552945 1.0 0.928800825906375 27 Q9UHX1,Q96EK5,Q9UBM7,O43505 4 +Epistaxis 0.4556294010084087 0.808149054376265 0.4190047814042119 1.0 0.928800825906375 12 P04062,P01889 2 +Abnormally lax or hyperextensible skin 0.4270620278065715 0.8054762522849476 0.4205449049059948 1.0 0.929687526687582 38 O96000,P04062,Q9Y487,Q15555,O75787,Q8NCH0,Q9NWM8,Q9Y4P3,Q9UHX1,Q15904 10 +Skin rash 0.4211566987826119 0.8045349151632706 0.4210881132700266 1.0 0.929687526687582 18 P28070,Q06136 2 +Poor eye contact 0.4289595911328582 0.8041081174030223 0.4213345369585517 1.0 0.929687526687582 29 O96000,Q96CU9,O75306,O43676,Q5XKP0,Q9UHX1,Q5KU26,Q06787 8 +Upper limb amyotrophy 0.4601986995979537 0.8039580508819937 0.4214212021842924 1.0 0.929687526687582 11 Q9NR77 1 +Limb girdle muscular dystrophy 0.537051230124296 0.8017104659477408 0.4227204603066885 1.0 0.9308632589024692 7 O14979 1 +Multiple myeloma 0.7668433005298971 0.800960208009772 0.4231546825752363 1.0 0.9309655284703872 2 P04062 1 +Occipital meningocele 0.5922526621398003 0.8006729364683658 0.4233210141044632 1.0 0.9309655284703872 4 Q10713 1 +Abnormal lymphocyte morphology 0.4281132658757866 0.7980894612726899 0.4248185767208119 1.0 0.9327082292567122 29 P28070,O00754,P04066,P16278 4 +Duplication involving bones of the feet 0.4260437181116331 0.7980003601161899 0.4248702811330869 1.0 0.9327082292567122 17 Q14739,Q9UBM7,Q10713,O75845 4 +Disinhibition 0.410977400506929 0.7938987067451524 0.4272544026368241 1.0 0.932834864823334 50 P04062,Q96N66,P05067,Q13501,Q9H2C2,O00592,P35637,Q06787 8 +Hemoptysis 0.5905127970160486 0.7936886887340215 0.4273766868221362 1.0 0.932834864823334 4 P01889 1 +Nausea and vomiting 0.3867063371063305 0.793522070446377 0.4274737157724826 1.0 0.932834864823334 115 Q16836,P06280,P07602,Q13501,Q8IZA0,Q01844,P42892,Q9Y619,P35637,Q9NZ08,O96000,P01889,P11117,O00592,Q9UBM7,Q92804,Q9Y4P3,Q9NPL8,P23786,P38571,Q96CU9,O75306,O43676,Q13423,P50995 25 +Hyperkeratosis 0.4108681628807291 0.7929604075823189 0.4278008905757773 1.0 0.932834864823334 50 Q14126,Q9NWM8,P06280,Q06136,O75844,P04066,P53634,Q14574 8 +Atrophic scars 0.5539008979384941 0.7921001729542523 0.4283022692642428 1.0 0.932834864823334 6 Q9NWM8,P53634 2 +Abnormal c peptide level 0.6583547949640122 0.7905266749824962 0.4292202501500259 1.0 0.9331488554039128 3 Q16836 1 +Abnormality of the nasal tip 0.3465045655644492 0.7904546819174859 0.4292622783443287 1.0 0.9331488554039128 79 P23786,Q9Y487,P16278,P21964,P10644,O75845,P38159,Q96EK5,O75844,Q03164,P42892,Q9UHX1,Q96A33,P16435,Q06787 15 +Abnormality of the pulmonary veins 0.5535005099293785 0.7903669615403803 0.4293134910795646 1.0 0.9331488554039128 6 Q15392 1 +Head tremor 0.4472324764231725 0.7902323241811658 0.4293921017007847 1.0 0.9331488554039128 13 Q99720 1 +Increased sensitivity to ionizing radiation 0.5890837433670111 0.7879606501023465 0.4307197231704986 1.0 0.9349261849969596 4 Q969G3,Q12824 2 +Congenital craniofacial dysostosis 0.7626797880393612 0.785369578023461 0.4322369121392735 1.0 0.9355064927313144 2 P10644 1 +Aplasia hypoplasia of the nasal bone 0.7626797880393612 0.785369578023461 0.4322369121392735 1.0 0.9355064927313144 2 P10644 1 +Weakness of muscles of respiration 0.4257035524144182 0.7828363931461602 0.4337231933288303 1.0 0.9369842087737832 28 Q13510,P12235,O95831,P10253,P50402,Q15067,O95140,P22626 8 +Babinski sign 0.3470318512113589 0.7827877177865488 0.4337517812482154 1.0 0.9369842087737832 80 O95831,Q9H6K4,O75787,O43681,O75477,Q15067,P07602,Q99720,Q13501,O95140,Q9NR77,Q9NZJ7,P07196,P35637,O14773,O00754,Q6DKK2 17 +Abnormality of the abdominal wall 0.3695419809868281 0.7807343872640017 0.4349587312616998 1.0 0.9369842087737832 100 Q10713,P16278,Q9Y487,O00462,P21964,P08236,Q9NWM8,Q8NCH0,Q32P28,Q14739,Q9Y4P3,O75844,P04066,Q9UHX1,Q9UBM7,O00754 16 +Glioma 0.4748122920526946 0.779251778365785 0.4358314144507527 1.0 0.9369842087737832 10 P48735 1 +Abnormality of blood circulation 0.381110038983858 0.7775789993057626 0.436817245482713 1.0 0.9369842087737832 62 P23786,P04062,P01889,Q9Y487,P21964,P10644,P05067,Q14739,O75844,Q9UHX1,Q9NZ08 11 +High pitched voice 0.4744816626844126 0.7774662268806214 0.4368837526547098 1.0 0.9369842087737832 10 O75844 1 +Intellectual disability progressive 0.5314707249074642 0.7762583501948166 0.4375964596627701 1.0 0.9376177407203944 7 Q9H2M9,O95831,P18074,Q15067 4 +Advanced eruption of teeth 0.4918447599478346 0.7752299286484573 0.4382038062253306 1.0 0.9380234955948332 9 O75844 1 +Abnormal sternal ossification 0.585532442415679 0.7737603496547942 0.4390725241638931 1.0 0.9385410309471888 4 Q9Y619,O96028 2 +Bone fracture 0.5306725032698019 0.7726242571365517 0.4397447843819302 1.0 0.9389359659147808 7 Q13501,Q13126 2 +Abnormal posterior segment imaging 0.5851001577872968 0.7720352218464508 0.440093566744737 1.0 0.9389359659147808 4 P04439 1 +Corneal ulceration 0.5543948487504806 0.7679601455348838 0.4425108628956182 1.0 0.9418560593669296 5 O75844 1 +Unsteady gait 0.4206527979407226 0.7673376090292714 0.4428808131361335 1.0 0.941856887269209 40 O95831,Q10713,O75503,Q9H6K4,O75787,Q5JRX3,Q9H2C2,Q9NR77,O75569 9 +Apraxia 0.3954728319683637 0.7653754673375918 0.4440479971078259 1.0 0.942333854822217 56 P04062,Q10713,O75787,P35270,P05067,Q13501,Q9Y619,P35637,O14773,Q6DKK2 10 +Sensorimotor neuropathy 0.4217279361933863 0.7647608535254898 0.4444139622608452 1.0 0.942333854822217 25 O95831,O15270,P05023,O00429,P00403,P07602,P40939,Q9NR77,P07196,Q8N2K0,Q5KU26,Q9NZJ7 12 +Abnormal endocrine physiology 0.5831231096686121 0.7641550483046806 0.444774850808439 1.0 0.9423557155696652 4 Q13423 1 +Lipodystrophy 0.422557489829946 0.7631586000772287 0.4453688155390112 1.0 0.9430227961271568 36 Q14126,Q9Y487,O75844,P04066,P28070 5 +Female sexual dysfunction 0.5525960144085227 0.7604327789439823 0.4469959360536413 1.0 0.9457452154734146 5 P01889 1 +Limb girdle muscle atrophy 0.4711994847677139 0.7597558524556762 0.4474005363420059 1.0 0.9457452154734146 10 O14979 1 +Dysgraphia 0.43085026674686 0.7567391291142377 0.4492061673391838 1.0 0.9457452154734146 15 P05067 1 +Bundle branch block 0.4519436941046451 0.756522151600924 0.4493361963266933 1.0 0.9457452154734146 11 P06280 1 +Abnormal macroscopic urine appearance 0.4195841293048354 0.7561864072817642 0.4495374412444786 1.0 0.9457452154734146 17 P23786 1 +Macroorchidism 0.6490676361166786 0.7557063655847611 0.4498252666721827 1.0 0.9457452154734146 3 Q06787 1 +Abnormality of lipoprotein cholesterol concentration 0.4516213436148995 0.7546731578289979 0.4504451159870037 1.0 0.9457452154734146 11 P50402,P38571,Q8N511,Q10471 4 +Cerebellar cyst 0.421699202304514 0.7539744823223173 0.4508645443883656 1.0 0.946183490115958 35 P23786,Q9UBM7,O43505 3 +Polyneuropathy 0.4131947456953523 0.7519016835251253 0.4521101856432112 1.0 0.9479116917477411 18 O95831,Q15041,P07602,P04066,P35670,Q9NZJ7 6 +Spinal muscular atrophy 0.4869602213181675 0.7503995109709427 0.4530141253889077 1.0 0.9484785254646082 9 Q13510,Q99720 2 +Abnormal pyramidal sign 0.3796420379334008 0.7481047537387269 0.454396974893867 1.0 0.9509304819423842 112 O95831,P07602,Q13501,P07196,Q9Y619,P35637,Q6DKK2,Q9NZ08,P01889,O75787,O00429,O75477,O00592,O14773,O43681,P04066,P51648,P17900,Q9H6K4,O75306,Q15067,Q99720,Q9NZJ7,Q9NR77,O95140,O75569,O00754 27 +Low alkaline phosphatase 0.7517032551097612 0.7446728343442359 0.4564695254654165 1.0 0.9512814602620664 2 P38571 1 +Bulbar palsy 0.4497022881163162 0.7436713342898402 0.4570753356998858 1.0 0.9512814602620664 11 Q13501,P35637 2 +Abnormal morphology of the musculature of the neck 0.4437747532676525 0.7387452150596315 0.4600617243323768 1.0 0.9512814602620664 12 Q99720,P35637 2 +Abnormality of dental color 0.644348667158159 0.7381635798734586 0.4604150515591914 1.0 0.9512814602620664 3 P16278 1 +Vitreous hemorrhage 0.5761363636363721 0.7364392307747374 0.4614634372616288 1.0 0.951321488079377 4 O75533,Q99496,P35222 3 +Aspiration pneumonia 0.415251464188923 0.7362214974067051 0.4615959115631329 1.0 0.951321488079377 22 Q13510,P16278 2 +Fasting hyperinsulinemia 0.5754676050134145 0.7337975461020458 0.4630721363591892 1.0 0.9517880843886126 4 Q16836,P00367 2 +Abnormal circulating free fatty acid concentration 0.5740656493123435 0.7282662281026103 0.4664506314374077 1.0 0.953541104439945 4 Q16836 1 +Sclerosis of skull base 0.6416636956418075 0.7282298391432613 0.466472902795493 1.0 0.953541104439945 3 Q14739 1 +Dysuria 0.5019490744601101 0.727726141228904 0.4667812447402473 1.0 0.9537372930520704 8 Q8N5K1,O76024,Q8N0X7,P01889 4 +Aortic regurgitation 0.4146417184487074 0.7261165691891526 0.4677673123055912 1.0 0.9544493410106362 23 Q9UHX1,O00754,O75844,P01889 4 +Distal upper limb muscle weakness 0.5433480864355281 0.7219200026201286 0.4703436625577573 1.0 0.9568906727552264 5 Q13501 1 +Pulmonary hypoplasia 0.4131357064705064 0.7219138275565748 0.470347459309155 1.0 0.9568906727552264 22 Q8TAA9,Q14739,Q9UBM7,O75844 4 +Thoracic hypoplasia 0.4147087551103734 0.7211563276784464 0.4708133381388846 1.0 0.9568906727552264 24 P04062,Q14739,P16435,Q9UHX1,Q96A33,O75718 6 +Decreased circulating aldosterone level 0.7452687358062045 0.7211072705543157 0.4708435181109922 1.0 0.9568906727552264 2 Q13423 1 +Diffuse mesangial sclerosis 0.4303938917371612 0.7209319237257337 0.4709514003127317 1.0 0.9568906727552264 14 Q9NQW6 1 +Restless legs 0.5720560289030694 0.7203532255817509 0.4713075413347942 1.0 0.9568906727552264 4 O95140,O00592 2 +Abnormality of the achilles tendon 0.4405123782594644 0.7197088116039014 0.4717042997809293 1.0 0.9569223742478344 12 Q08J23,P50402,Q9Y3E5,Q15041,Q8N2K0 5 +Delayed fine motor development 0.5184688910811031 0.7172939111032867 0.4731927634781709 1.0 0.9570476199858218 7 Q5KU26,P16435 2 +Abnormal iliac wing morphology 0.4799106280729271 0.7146869943849862 0.4748024758856837 1.0 0.9589635352940306 9 Q8TAA9,P16278 2 +Left ventricular systolic dysfunction 0.5403052024409766 0.7093207234015124 0.4781254711326796 1.0 0.9618692157085944 5 O75844 1 +Abnormal ldl cholesterol concentration 0.4618129795231073 0.7092761996377435 0.4781530949834383 1.0 0.9618692157085944 10 P50402,Q8N511 2 +Parkinsonism with favorable response to dopaminergic medication 0.4787947005082698 0.7090486495833533 0.47829428734225 1.0 0.9618692157085944 9 P04062,P07602 2 +Abnormality of peripheral nerves 0.4143107548996741 0.7080349220073963 0.4789235711629547 1.0 0.9618692157085944 38 O95831,O15270,O15269,O43681,P07602,Q99720,Q9NR77,P07196,Q9Y619,O95140,Q9NZJ7 11 +Abnormal diaphysis morphology 0.3868823066710696 0.7072957246825312 0.4793827218417437 1.0 0.9618692157085944 57 P16278,Q9Y487,P08236,Q32P28,Q14739,Q9NR77,O00754,Q9Y619,O75718 9 +Tremor by anatomical site 0.4124009187295989 0.7053526841821449 0.4805907816906427 1.0 0.9618692157085944 24 Q16637,O95140,Q99720,Q9NR77,P35637 5 +Cutis laxa 0.414209001457644 0.7048811098745071 0.4808842267444362 1.0 0.9618692157085944 27 O96000,Q9Y487,O75787,Q8NCH0,Q9Y4P3,Q15904 6 +Abnormal periventricular white matter morphology 0.4153685192591904 0.7043382771364978 0.4812221343394025 1.0 0.9618692157085944 33 O75503,P11177,O00429,O43681,P07602,Q9UHX1,P17900 7 +Abnormality of endocrine pancreas physiology 0.5673227121855241 0.701791445366493 0.4828092345031125 1.0 0.9618692157085944 4 Q14739 1 +Phenotypic variability 0.3470159103765622 0.7002689267650334 0.4837593733747336 1.0 0.9618692157085944 86 Q13510,P07602,P07196,Q06787,Q9H061,O00429,P36551,O95470,O14979,Q6P4A7,P35270,Q92733,Q70HW3,Q12824,P17900,P52732,P50995,Q969G3,Q9NR77,O95140,Q9NZJ7 21 +Reduced consciousness confusion 0.3614747625765888 0.6991291950170795 0.4844712947210903 1.0 0.9618692157085944 99 P12235,Q16836,O43819,P07602,P05067,Q99496,P20674,Q9Y619,Q99567,Q96IX5,Q9NZ08,O96000,P01889,P00403,Q9UMS0,P36551,P18074,Q9UBM7,P35670,P04062,O43681,P35270,Q9NPL8,O43772,Q12824,P23786,Q96CU9,O75306,O43676,Q13423,P00367,Q969G3,Q9NZJ7,P40939,O00754 35 +Abnormality of humoral immunity 0.4029368053579244 0.6978492212601539 0.4852714932673938 1.0 0.9618692157085944 48 O75787,P02786,P28070,Q14108,Q15904,O00754 6 +Hirsutism 0.3994308951270178 0.6946574054998483 0.4872700275419626 1.0 0.9618692157085944 50 P16278,P08236,P15586,P54802,P53634 5 +Death in infancy 0.4024793109172455 0.6939999255493047 0.4876822556103595 1.0 0.9618692157085944 48 P38571,P04062,P16278,O60508,O43819,O00429,P07602,Q15067,Q9NZJ7,Q6NUK1,P20674,O75381,P18074,Q9BT22,Q15904,O75718,P51114,O60828 18 +Motor axonal neuropathy 0.4359111570442009 0.6929175435318532 0.4883612993728652 1.0 0.9618692157085944 12 O15269,O95831,P22626 3 +Chorioretinal degeneration 0.536183809308789 0.692317672550823 0.4887378542017733 1.0 0.9618692157085944 5 Q9Y619 1 +Chorioretinal atrophy 0.536183809308789 0.692317672550823 0.4887378542017733 1.0 0.9618692157085944 5 Q9Y619 1 +Low frustration tolerance 0.5126973483505424 0.6912946448288255 0.4893803964742407 1.0 0.9618692157085944 7 Q9UHX1,P04062 2 +Schwannoma 0.6314606155792605 0.6908143818593063 0.4896821963936131 1.0 0.9618692157085944 3 P10644 1 +Aplasia hypoplasia of the clavicles 0.4581449179530856 0.6896283319913785 0.490427945691358 1.0 0.9618692157085944 10 O75844 1 +Fat malabsorption 0.5119226192584527 0.6878138749030721 0.4915699975198238 1.0 0.9618692157085944 7 P38571,Q96A33,Q14739 3 +Vascular neoplasm 0.4123697496510408 0.6862705269994706 0.4925425309021061 1.0 0.9618692157085944 29 P10619,Q9UBM7,O75874,P48735 4 +Skin vesicle 0.4740394893766089 0.6850723438217764 0.4932982710723075 1.0 0.9618692157085944 9 P98194,Q14574,P16615 3 +Short palpebral fissure 0.4082898778119249 0.6829329691799317 0.494649199785615 1.0 0.9618692157085944 23 Q15555,O75844,Q9Y619,P55795,Q9UHX1 5 +Subcutaneous hemorrhage 0.4122126269598272 0.6819502036426524 0.495270438828844 1.0 0.9620499743859596 34 P04062,Q13126,P10644,P21964,Q9NWM8,Q8NCH0,Q16625,Q14108 8 +Scotoma 0.4387709067515303 0.6812206497886093 0.4957318836473789 1.0 0.9625299997667008 11 Q9H6K4,O75306,Q9H061,O00429,P04439 5 +Lung adenocarcinoma 0.6279404122798451 0.6780344447808566 0.4977498538864351 1.0 0.9639476471772228 3 P30154 1 +Protrusio acetabuli 0.6275128058344179 0.6764867408135944 0.4987316615608703 1.0 0.9650167566005468 3 O75718 1 +Skin plaque 0.5321001800198213 0.6755442165027843 0.4993300690109103 1.0 0.9657585443273036 5 P16615,Q06136 2 +Abnormal nerve conduction velocity 0.410548931708759 0.6730163968613273 0.5009368594376988 1.0 0.9672673038436144 36 O95831,O15269,O43681,P07602,Q99720,Q9NR77,P07196,Q9Y619,O95140,Q9NZJ7 10 +Abnormality of the testis size 0.4046222388443271 0.6713988274479812 0.5019664916995044 1.0 0.9672673038436144 21 P51809,O43505,Q06787 3 +Prolonged bleeding following procedure 0.7308856926570743 0.6692812959564198 0.5033160558175565 1.0 0.9672673038436144 2 Q02241 1 +Limb undergrowth 0.4042216458912892 0.6667022395776308 0.5049623479724255 1.0 0.9672673038436144 44 P10644,Q15392,Q14739,O75874,Q9BV10,Q9UHX1,Q9UBM7,O75718,P48735 9 +Autoamputation 0.5581529666950741 0.6661540893301736 0.505312614655073 1.0 0.9672673038436144 4 O15269,O15270 2 +Abnormal cranial nerve physiology 0.3751066601211139 0.6650596086068673 0.5060123678438009 1.0 0.9672673038436144 60 Q13510,P12235,O43819,P48651,Q9Y3E5,P07602,Q13501,O75874,P07196,Q9NZ08,P01889,P51798,Q9UHX1,Q12824,Q969G3,Q9Y5P6,Q9NR77,Q9NZJ7,P48735 19 +Abnormal platelet volume 0.4887176865661384 0.6647873548313995 0.5061865116894342 1.0 0.9672673038436144 8 O75845 1 +Distal sensory impairment of all modalities 0.5294065238154171 0.6645222056446362 0.5063561414687903 1.0 0.9672673038436144 5 O95140,O15269 2 +Widened cerebral subarachnoid space 0.6236300535586126 0.6624809936998862 0.5076630116263174 1.0 0.9685467431105852 3 Q9BV10 1 +Difficulty walking 0.3694938713154156 0.6619632753580854 0.5079947580576434 1.0 0.9685467431105852 62 Q13510,O00429,O75477,P07602,Q15041,Q13501,P35670,O43681,Q9H2C2,Q15067,Q99720,Q9NR77,O95140,P35637,O14773 15 +Ectropion of lower eyelids 0.7286146858440541 0.6612124272175706 0.5084760927302849 1.0 0.9685467431105852 2 Q99496 1 +Abnormality of the bladder 0.359118931403004 0.6586583210235963 0.5101152028442517 1.0 0.9704204193812612 100 P12235,P07602,Q99496,Q13501,P07196,P22626,P35637,Q8N5K1,Q3ZCQ8,Q06787,P01889,P21964,Q9NWM8,Q9UHX1,P04062,O43681,Q10471,Q9Y4P3,Q8N0X7,Q12824,Q8TAA9,O95630,Q8NCH0,Q99720,Q86XL3,P07686,Q9NR77,Q969G3,P16435,Q9NZJ7 30 +Prominent forehead 0.374403600377902 0.6582404086889545 0.5103836630101402 1.0 0.9704204193812612 60 P23786,Q15392,Q14739,P15586,P04066,Q9UHX1,O00754,Q06787 8 +Abnormal enzyme coenzyme activity 0.4136452620053505 0.6572326980072251 0.5110313038750403 1.0 0.9708297739859584 155 Q13510,Q16836,Q5JRX3,P07602,Q13501,Q9Y619,P22626,Q10713,P16278,P01889,O75787,P61916,O75845,Q14739,Q02241,Q5XKP0,P04062,P10619,Q16625,O43772,P28070,O43505,P23786,P38571,P10253,Q8N511,Q15067,Q07021,P07686,O15118,Q15904,O00754 32 +Dilatation of the cerebral artery 0.4868641351427848 0.6560245090232997 0.5118083547786134 1.0 0.9718948504485214 8 P10253 1 +Peritonitis 0.424173318129987 0.6531402270105914 0.5136658806227272 1.0 0.9737752088968628 13 Q92621,Q8N1F7,P52565,P57740,Q12769,Q03426,Q8WUM0,Q9NQW6,O43707,Q9BW27,Q8NFH4,Q9Y5K6 12 +Bilateral tonic clonic seizure with generalized onset 0.5034637966659199 0.6499629881146265 0.5157161295312176 1.0 0.9751920579893468 7 Q13510 1 +Nail dysplasia 0.4022185220340855 0.6482724060224176 0.516808778056884 1.0 0.9759072094753394 22 P10321,P42892 2 +Hypertriglyceridemia 0.3987812573751094 0.64826237655664 0.5168152638277523 1.0 0.9759072094753394 19 P50402,P38571,P28070 3 +Abnormal visual electrophysiology 0.4007708760164958 0.6475904267180219 0.5172498907522614 1.0 0.9759072094753394 45 P50897,O14773,O75503,P07602 4 +Abnormal circulating carbohydrate concentration 0.4070355859813157 0.6462624487104759 0.518109402476965 1.0 0.9759072094753394 30 O96000,Q96CU9,O75306,O43676,Q5JRX3,Q9NPL8,Q70HW3,Q9BWD1 8 +Restlessness 0.4066776069380462 0.6440083641259556 0.5195700102306848 1.0 0.9759072094753394 36 P04062,P48449,P10644,P05067,Q13501,P42892,O00592,P35637,Q92804 9 +Mediastinal lymphadenopathy 0.6184177325914544 0.6438182749791127 0.5196932817776585 1.0 0.9759072094753394 3 Q01844 1 +Chromosome breakage 0.4840393075302342 0.6426982657897484 0.5204199065295376 1.0 0.9759072094753394 8 P33991,Q99496,Q969G3,Q12824,Q06787 5 +Polydactyly 0.4046726495651305 0.6384056454906524 0.5232096569295746 1.0 0.9771747971802188 39 Q2VPK5,Q10713,O75845,Q15067,Q14739,Q9UHX1,Q9UBM7 7 +Stenosis of the external auditory canal 0.5006065808836617 0.6372455949183933 0.5239648826961498 1.0 0.9780242261797212 7 O96028,P55011,P16435 3 +Exaggerated cupid s bow 0.5003485540744148 0.636098915061426 0.524711952629312 1.0 0.978198995125878 7 P61978,P11233 2 +Muscle spasm 0.3890498060598395 0.6341902141003933 0.5259566932026698 1.0 0.9791044178039296 52 P12235,P04062,P23786,Q9H6K4,P05023,Q16637,P06280,Q15165,P50995,P53985,Q13501,O95140,P40939,Q9NR77,P07196,O00592,P35637,Q92804 18 +Abnormality of the extraocular muscles 0.7199091597274755 0.6305896743629977 0.5283088520472317 1.0 0.9791044178039296 2 P43243 1 +Abnormal cellular phenotype 0.4067816595391098 0.6305007655698206 0.528367002057669 1.0 0.9791044178039296 150 Q13510,O75503,Q16836,P11177,P07602,Q13501,P15586,Q9UBX3,P35637,Q14108,Q06787,O96000,O75787,P21964,O00429,Q14739,O75844,O14773,P04062,O43772,P28070,Q70HW3,P23786,P02786,Q96CU9,O43676,O75306,Q15904,O00754 29 +Tongue fasciculations 0.4468907518224037 0.6296801407488727 0.5289038783327396 1.0 0.9791044178039296 10 Q13510,Q16637,P51114 3 +Vestibular dysfunction 0.4019691639091068 0.6286752758838067 0.5295616676387698 1.0 0.9795146002329964 25 P06280,P01889,Q9NZ08 3 +Abnormal aortic valve morphology 0.4047683271640737 0.626872973663652 0.5307425043309035 1.0 0.9798318670297018 33 P04062,P01889,P21964,P06280,O75844,Q9UHX1 6 +Paraplegia paraparesis 0.3685230379631764 0.6259380856778778 0.5313555524326272 1.0 0.9798318670297018 61 Q13510,P04062,Q9H6K4,O75787,Q96CU9,O75306,O00429,Q15041,Q13501,Q5XKP0,Q9Y619,P35637,O00754,Q6DKK2 14 +Minimal change glomerulonephritis 0.4240121580546989 0.6240115287158006 0.5326200138197663 1.0 0.9798318670297018 12 Q92621,Q8N1F7,P52565,P57740,Q12769,Q8WUM0,Q9NQW6,O43707,Q9BW27,Q8NFH4,Q9Y5K6 11 +Vomiting 0.3302272898020282 0.6213645151539873 0.5343598141066326 1.0 0.9815173518007718 73 O96000,P38571,P23786,Q16836,Q96CU9,O75306,O43676,Q13423,P06280,P07602,P11117,Q9NPL8,Q9Y619,Q9UBM7 14 +Respiratory tract infection 0.3863730056510455 0.6139718980553701 0.5392338974033892 1.0 0.9850870750844968 130 Q13510,P04062,P10253,P16278,Q9Y487,P01889,P02786,O00462,P08236,P07602,P15586,P54802,P04066,P53634,O00754 15 +Malrotation of small bowel 0.5441084645231041 0.6124820545872018 0.5402188674842059 1.0 0.9850870750844968 4 O96028,Q8NCH0 2 +Increased blood pressure 0.3720648387869952 0.6119062811810225 0.5405997656204233 1.0 0.9850870750844968 59 Q8TAA9,P38571,P04062,Q10713,P01889,P21964,P10644,P06280,Q9Y4P3,O75844,P42892,Q06787 12 +Steroid resistant nephrotic syndrome 0.5161045850701063 0.6106274431817041 0.5414462503380784 1.0 0.9850870750844968 5 Q9BW27,Q8WUM0,Q12769,Q8N1F7 4 +Cyanosis 0.3914166458283528 0.6087610900513707 0.5426828078711534 1.0 0.9850870750844968 18 O75844,P04066 2 +Sparse eyelashes 0.406710988152917 0.6078227610990377 0.5433050315708283 1.0 0.9850870750844968 15 O75844 1 +Jaundice 0.3956927118536878 0.6062275342172273 0.5443636712762481 1.0 0.9850870750844968 45 P38571,O75787,P10644,P61916,Q14739,Q16625,O15118,Q15904 8 +Dilated fourth ventricle 0.4010006887723292 0.6036746473639448 0.5460599729279263 1.0 0.9863999366206376 37 P23786,Q9UBM7,O43505 3 +Short nose 0.3319068194835198 0.6025819160567846 0.5467868536395066 1.0 0.9863999366206376 80 P04062,Q9Y487,O95630,Q8NCH0,P10644,O75845,Q15392,Q9Y4P3,O75844,Q03164,P42892,Q9UHX1,Q5KU26 13 +Myalgia 0.4000323112752151 0.5991826424636705 0.5490510963133222 1.0 0.9871704224962166 38 P23786,P01889,P21964,P06280,Q14739,Q9NZ08,Q06787 7 +Breast carcinoma 0.4098698714371032 0.5971808534609139 0.5503866408755322 1.0 0.9871704224962166 14 P48735 1 +Abnormal brain lactate level by mrs 0.474084193675343 0.596031819302743 0.5511539701857631 1.0 0.9872559155006332 8 O43819,O00429,O75306 3 +Dicarboxylic aciduria 0.3891431326893243 0.59392457723508 0.5525625599197497 1.0 0.9872559155006332 18 P23786,P48735,O43772 3 +Abnormality of the cerebrospinal fluid 0.3703244445091073 0.5913561337958887 0.5542818255203774 1.0 0.9892831127933782 116 O95831,O43819,P48651,P07602,Q99496,O96028,O96000,Q10713,Q08J23,P21964,P10644,P51798,P55011,P00403,Q9UBM7,P04062,O43681,Q15392,Q16625,Q9NPL8,Q12824,O43505,Q8TAA9,P23786,Q96CU9,O75306,O43676,P08236,Q969G3,Q9NZJ7,Q9NR77,Q9Y5P6,P16435,O95140,O00754 35 +Chronic hepatic failure 0.6031440095222996 0.5901148568433925 0.5551136490562039 1.0 0.9892831127933782 3 Q10713 1 +Aplasia hypoplasia of the radius 0.4036987367416944 0.5894103957944729 0.55558600446974 1.0 0.9893484322258534 15 P10644,Q9UBM7 2 +Profound sensorineural hearing impairment 0.5106674445669431 0.5888772122502045 0.5559436452781723 1.0 0.989592909609303 5 Q9NR77 1 +Brushfield spots 0.7074186222558627 0.587557042171198 0.5568296521977689 1.0 0.9905209224661417 2 O75381 1 +Microcornea 0.3938210484630441 0.5850563699704534 0.558509814295667 1.0 0.9921944525323736 23 P52732,Q15555,Q8NCH0,Q9NWM8,O75845,Q9H2M9,P18074,O43505 8 +Pectus carinatum 0.3982084135319993 0.5834779896412029 0.5595715698520991 1.0 0.9930500993602792 30 O00754,P08236,P16278 3 +Abnormal brainstem morphology 0.3375466247991608 0.5831475253078795 0.5597939927452655 1.0 0.9930500993602792 70 O96000,O95831,Q10713,Q96CU9,O43819,O75306,P11177,O00429,O43676,Q969G3,Q96EK5,Q9NPL8,Q9Y5P6,O43505,Q9Y320,Q5KU26,Q12824,Q06787 18 +Cranial hyperostosis 0.4380339083183572 0.582923198075274 0.5599450032459212 1.0 0.9930500993602792 10 P48651,P10644,P22626,O00754 4 +Vertebral fusion 0.4376105636665959 0.5806989232455032 0.561443387553235 1.0 0.9930500993602792 10 Q9UHX1 1 +Abnormal sputum 0.5085515717976685 0.5804605177582786 0.5616041045753071 1.0 0.9930500993602792 5 P01889 1 +Blue sclerae 0.3884547960223645 0.5803542880094732 0.5616757247254207 1.0 0.9930500993602792 19 Q8NCH0,O75718 2 +Decreased specific antibody response to protein vaccine 0.7047691143073387 0.5785739557783083 0.5628766823018836 1.0 0.9930500993602792 2 Q9BV10 1 +Bruising susceptibility 0.3952378317747997 0.5774241965813575 0.563652932547855 1.0 0.9930500993602792 26 P04062,Q13126,P10644,Q8NCH0,Q9NWM8,Q14108 6 +Limb muscle weakness 0.3581624549258573 0.5756184474231244 0.5648731092560966 1.0 0.9930500993602792 63 Q13510,P12235,O15270,O43819,Q13126,Q13501,P07196,O15269,Q14739,P36551,P35670,P50402,Q16637,Q8N0X7,Q12824,P05023,Q15067,Q99720,Q969G3,P40939,Q9Y5P6,Q9NR77,P51149,O95140 24 +Pancreatic islet cell hyperplasia 0.5976925020926191 0.571328682582502 0.5677768623878401 1.0 0.9930500993602792 3 Q14739 1 +Abnormality of the adrenal glands 0.3923587751399048 0.5710848171860474 0.5679421499055999 1.0 0.9930500993602792 44 P38571,O00170,Q13423,P10644,Q02978,Q99496,P51809,Q969G3,O75874,O75844,P16435,O75381,P48735,O95470,Q12824 15 +Stuttering 0.7024981074943182 0.5709162287991948 0.5680564294980648 1.0 0.9930500993602792 2 P00403 1 +Sloping forehead 0.3949162431542553 0.5675032052253839 0.5703723495639388 1.0 0.9930500993602792 40 P23786,O95630,O75845,Q86XL3,Q16625 5 +Dyslexia 0.4846375151881551 0.5668931183546982 0.5707867998861396 1.0 0.9930500993602792 7 Q13501,Q9H6K4 2 +Abnormal cornea morphology 0.3773084331941286 0.5664394272405957 0.5710950988303225 1.0 0.9930500993602792 125 Q13510,P06280,Q9NZ08,P16278,P01889,P21964,Q9NWM8,O75845,Q14739,O75844,P35670,Q9UBM7,P04062,P10619,Q9Y4P3,Q16625,P04066,P51648,O43505,Q15555,P08236,Q8NCH0,Q06136,Q07021,Q96EK5,O75569,O00754 27 +Neonatal onset 0.3949554866028075 0.5659638630838794 0.571418346331428 1.0 0.9930500993602792 16 O75787,Q15904,O14654 3 +Abnormal urine protein level 0.3871474862420392 0.5651538824077446 0.5719691016266766 1.0 0.9930500993602792 48 P04062,P06280,P35670,Q9NQW6,Q14108,O95470 6 +Nausea 0.3943624657051904 0.5622789017806594 0.5739260107739832 1.0 0.9945182381529668 16 P06280 1 +Ulnar claw 0.5940764216285025 0.5589855933426537 0.5761715523816597 1.0 0.9961926751521002 3 Q9NR77 1 +Dermal atrophy 0.3908261127343354 0.5584522553491504 0.5765355985072751 1.0 0.9961926751521002 24 Q8NCH0,Q9NWM8,Q15392,O75844,P53634 5 +Hand tremor 0.4164702040482956 0.5554053198209327 0.5786174546747256 1.0 0.9986931486551424 11 Q92734,Q16637,Q9H2M9,P07196,O95140 5 +Gangrene 0.4478681504858238 0.5549151569819106 0.578952694058716 1.0 0.9988768916702624 9 P10644,P01889,Q9NZ08 3 +Hydrocele testis 0.5906598171537012 0.5474127568430958 0.5840951930618994 1.0 1.0 3 Q9UBX3 1 +Proptosis 0.3915346334925212 0.5458957594397411 0.5851375934611274 1.0 1.0 41 Q32P28,O75844,Q9UBM7,Q5KU26,O00754 5 +Widely spaced teeth 0.3904504061499644 0.5445657092109742 0.5860522442173481 1.0 1.0 26 O00754,P08236,P16278 3 +Chromosomal breakage induced by crosslinking agents 0.6945495836487466 0.5444289280825293 0.5861463436509542 1.0 1.0 2 P13073 1 +Bulbous nose 0.3934255164348419 0.5439399957740769 0.5864827649791593 1.0 1.0 34 P23786,P21964,O75845,P38159,Q96EK5,P42892,Q96A33,Q06787 8 +Brisk reflexes 0.3837319674325835 0.5407167783842496 0.5887028119465973 1.0 1.0 20 Q99720,P35637,Q5JRX3 3 +Femoral bowing 0.4619041550791284 0.539656424527462 0.589433996423677 1.0 1.0 8 O00754,Q32P28 2 +Arrhinencephaly 0.4294473020900766 0.5380205170399742 0.5905628841195592 1.0 1.0 10 Q8TAA9 1 +Abnormal anatomic location of the heart 0.4607943311199558 0.5345639174282153 0.5929514400168117 1.0 1.0 8 O75844 1 +Abnormality of the nail 0.3395455625970747 0.5317121757383086 0.5949253577073428 1.0 1.0 92 P23786,Q9Y487,Q06136,Q9Y619,O75844,P04066,P53634,P10321,P42892,Q14574 10 +Arthropathy 0.4961058403799019 0.5315327154928096 0.5950496767447726 1.0 1.0 5 O15269 1 +Hypopigmentation of the skin 0.391471613172858 0.5314646599305202 0.5950968245605828 1.0 1.0 32 Q8IZA0,P07602 2 +Concentric hypertrophic cardiomyopathy 0.6892505677516987 0.5270521505057734 0.5981573738058383 1.0 1.0 2 P00403 1 +Reduced tendon reflexes 0.3806378153341799 0.5251644319837333 0.5994688882603494 1.0 1.0 132 Q13510,P12235,O95831,O43819,P11177,Q96AY3,P07602,Q13501,P07196,Q8N2K0,P35637,Q06787,Q10713,O75787,O15269,O00429,O75477,Q15041,P54802,O00592,Q9BT22,P51114,O14979,P04062,P50402,Q16637,O43681,Q9H2C2,O43505,Q8TAA9,P10253,Q9NVV4,Q9H6K4,P05023,Q15067,Q99720,P40939,Q9NR77,Q9Y5P6,P51149,O95140,Q9NZJ7 42 +Dysarthria 0.3852883450442087 0.5231986757157968 0.6008360029053357 1.0 1.0 137 P12235,O75503,P07602,Q13501,P15586,P07196,P35637,Q14108,Q6DKK2,Q06787,Q10713,P61916,O75477,Q5XKP0,Q8IV08,P35670,O14773,P04062,O43681,P35270,Q9Y4P3,P51648,Q9H6K4,Q96CU9,O75306,P07686,Q9NZJ7,O15118,O75569,O00754 30 +Inguinal hernia 0.3413691023972758 0.5199954114582307 0.60306677324265 1.0 1.0 67 Q10713,P16278,Q9Y487,P21964,P08236,Q9NWM8,Q8NCH0,Q32P28,Q9Y4P3,Q9UHX1,O00754 11 +Obsessive compulsive behavior 0.3900678819595862 0.5194304962088079 0.6034605694673576 1.0 1.0 34 Q13501,Q5JRX3,O75503,Q6DKK2 4 +Abnormal erythrocyte sedimentation rate 0.4735426050406215 0.518849945806332 0.6038653851973528 1.0 1.0 7 P28070 1 +Infantile muscular hypotonia 0.3773280531759918 0.5175957403843534 0.6047403543774736 1.0 1.0 51 P10253,Q9Y487,P16278,P07602,O00754,P17900 6 +Abnormal muscle fiber morphology 0.3617904800265005 0.5136186628870177 0.6075186287974521 1.0 1.0 59 P12235,O95831,O14979,Q9H2D1,P23786,P50402,O43676,P22626,P05067,Q13501,Q99720,Q70HW3,P35637,P51114 14 +Adult onset 0.3681205859816797 0.5134408952420626 0.6076429451518108 1.0 1.0 56 O14979,P04062,Q16637,P07602,Q07021,O15118,Q9NQZ5,Q8IV08,Q9NZJ7,Q06787 10 +Ecchymosis 0.4044355206167999 0.5122524885845641 0.6084743122773302 1.0 1.0 12 P04062,Q8NCH0 2 +Telangiectasia 0.3860870118207697 0.5096691195491679 0.6102832908201414 1.0 1.0 27 P10619,Q14739,P06280,Q8IZA0 4 +Micropenis 0.3714133794067728 0.5091732239821718 0.6106308097120707 1.0 1.0 54 Q2VPK5,Q10713,P51809,Q9BV10,P42892,Q9Y619,P48449,Q9UBM7,O95470,O43505 10 +Cardiac conduction abnormality 0.3850575665649115 0.5077099764297947 0.6116567509449913 1.0 1.0 26 P23786,P50402,O75306,P06280,O43772 5 +Congenital nonbullous ichthyosiform erythroderma 0.5784439375620334 0.5067799008639916 0.6123092604741027 1.0 1.0 3 P04062 1 +Abnormal talus morphology 0.3853716322897922 0.5066896065272061 0.6123726243130239 1.0 1.0 16 Q9UHX1,Q99567,O75844,P16435 4 +Atelectasis 0.4376646032658867 0.5052268699469724 0.6133994998809902 1.0 1.0 9 Q13510 1 +Abnormal thrombosis 0.3807167694159846 0.5046945395323833 0.6137733968810215 1.0 1.0 22 P38571,P01889,O75874,P48735,Q9NZ08 5 +Decreased number of large peripheral myelinated nerve fibers 0.5146796659633223 0.5042856023445176 0.6140606934707007 1.0 1.0 4 O15269 1 +Open operculum 0.6816805450416303 0.5026363543318169 0.6152199646553218 1.0 1.0 2 Q92947 1 +Purpura 0.3777664323102514 0.5017062373925159 0.6158741763129603 1.0 1.0 20 P21964,P04062,Q8NCH0,Q16625 4 +Abnormal serum insulin like growth factor 1 level 0.5768480862757892 0.5015613839229288 0.6159760886582173 1.0 1.0 3 Q9BV10 1 +Neuronal loss in the cerebral cortex 0.4882514070216801 0.5012076371512073 0.6162249999942315 1.0 1.0 5 Q13501 1 +Recurrent fractures 0.3859510802310088 0.5002701142869921 0.6168848945479284 1.0 1.0 29 Q13126,Q32P28,Q13501,O75874,P16435,O75718,P48735 7 +Long fingers 0.330073926389139 0.4991729572922744 0.6176575439307297 1.0 1.0 70 P23786,Q15555,P21964,Q8NCH0,Q06136,Q96EK5,Q9BV10,P53634,P42892,Q9UHX1,Q03164,P55795 12 +Abnormal metacarpal morphology 0.3835935239753031 0.4977367981208259 0.6186695679027214 1.0 1.0 26 P16278,P10644,P08236,Q32P28,Q14739 5 +Specific learning disability 0.3734708742053819 0.4975451654898352 0.6188046611866314 1.0 1.0 52 P48651,Q13501,Q8TC12,P48506,Q9Y619,P35637,P22626,Q06787,Q10713,P21964,P10644,O75845,Q8N0X7,O43505,P52732,Q9H6K4,P00367,Q96EK5,O00754 19 +Adrenal hyperplasia 0.5127580706475436 0.4974516785531157 0.6188705703854582 1.0 1.0 4 P10644 1 +Muscular hypotonia of the trunk 0.3421010137192966 0.4964720133476678 0.6195614281518835 1.0 1.0 66 Q96N66,Q9Y5P4,P35270,P07602,Q16625,O00754,P17900 7 +Abnormality of prothrombin 0.4057903705579316 0.4962018493679866 0.6197520063458088 1.0 1.0 11 Q16836,Q9UJS0,P40939,Q9BV10,Q5XKP0 5 +Abnormal preputium morphology 0.5751609238924626 0.496067635186707 0.6198466927759898 1.0 1.0 3 Q9NVI1,O60828 2 +Mandibular prognathia 0.3864497859120964 0.493979020151679 0.6213209962338815 1.0 1.0 33 Q06787,O00170,P16278,P52732,Q9NVI7,P55011,P10644,P48651,Q15022,Q13045,Q9UHX1,O00754,O60828 13 +Abnormality of the upper arm 0.3732023327641416 0.4907519452533248 0.623601901833803 1.0 1.0 18 O14979,O15228,P50402,P48651,Q9BV10,P16435 6 +Hamartoma 0.3729712437522459 0.4892692207868219 0.6246511088364217 1.0 1.0 18 P48735 1 +Hyporeflexia of lower limbs 0.449621831563481 0.4837616310965549 0.6285550482034963 1.0 1.0 8 Q9NR77 1 +Optic nerve hypoplasia 0.3861523240227625 0.4832689408217767 0.6289047902435949 1.0 1.0 15 P37268,Q9Y5P6,P07196,Q9UHX1,P61978 5 +Abnormality of metacarpophalangeal joint 0.5079558801533495 0.4805104199988862 0.6308644956796268 1.0 1.0 4 P16435 1 +Rigidity 0.3728291139334134 0.478709049560601 0.6321456269905341 1.0 1.0 51 P04062,P16278,Q9H6K4,O75787,Q96CU9,O43681,P07602,P35270,Q15392,Q9H2C2,O00592,Q9NZJ7,Q06787 13 +Abnormal sternum morphology 0.3358486064392906 0.474897479086537 0.6348600483552258 1.0 1.0 93 Q13510,P04062,Q9Y487,P16278,Q15555,P50402,P08236,Q8NCH0,Q14739,Q9Y4P3,Q03164,Q9Y619,O75718,Q96A33,P55795,O00754,Q9UHX1,Q06787 18 +Renal dysplasia 0.416849473763189 0.4730547293740799 0.6361741335169413 1.0 1.0 10 O43505 1 +Abnormality of pain sensation 0.3779741471893592 0.4720739944465982 0.6368739739069471 1.0 1.0 24 O95831,O15270,O15269,Q8NCH0,Q9NR77,O95140,Q06787 7 +Exodeviation 0.3728111504113797 0.4694999442201347 0.6387123247140372 1.0 1.0 20 O43819,Q9Y3E5,Q10471,P40939,Q9UHX1,P55795 6 +Distal arthrogryposis 0.5045451239079278 0.4686002317168094 0.6393554116379776 1.0 1.0 4 Q8NCH0 1 +Limb girdle muscle weakness 0.3749343546012679 0.4665725874697476 0.6408057032356322 1.0 1.0 22 Q13126,O14979,Q9NZJ7,P07602 4 +External ophthalmoplegia 0.4000129707133922 0.4645383274354746 0.6422621062449183 1.0 1.0 11 Q07021,P12235 2 +Triangular mouth 0.4751762046805493 0.463474771820035 0.6430240940100653 1.0 1.0 6 Q10713 1 +Very long chain fatty acid accumulation 0.5645588792124135 0.4621122853956435 0.6440008005361986 1.0 1.0 3 O75381,P40855 2 +Hypocalcemia 0.3910923987866307 0.4608550846687229 0.64490257809689 1.0 1.0 13 P51798,P21964,P10644,P40939,Q9BV10 5 +Abnormal gallbladder morphology 0.380074190713782 0.4594102412865388 0.6459395952546436 1.0 1.0 29 P04062,P21964,O43681,O75845,P07602,Q9Y4P3,Q96A33 7 +Chronic rhinitis 0.56294912582065 0.4570449258883639 0.6476387545180802 1.0 1.0 3 Q9BV10 1 +Eeg with generalized slow activity 0.4433858561215943 0.4558052599466758 0.6485300213741398 1.0 1.0 8 O75503 1 +Abnormal facial expression 0.3794768209343319 0.4552713875498411 0.6489140080711977 1.0 1.0 29 P04062,O75787,P35270,Q9NR77,O00592,Q06787 6 +Hyperactive patellar reflex 0.4584755403867865 0.454927382920802 0.6491614821964273 1.0 1.0 7 P13073,O95394,Q15041,Q15233,P31040,P21912 6 +Abnormal fear anxiety related behavior 0.3339685538193908 0.4526738503008561 0.650783612062352 1.0 1.0 93 P12235,O75503,P06280,Q13501,P35637,Q6DKK2,Q06787,O60828,O76024,P21964,P10644,P55011,P00403,P36551,O00592,Q92804,O00170,P31930,Q15165,Q02978,Q9Y4P3,Q8N0X7,P55795,P17900,P50995,Q03164,O00754 27 +Symphalangism of middle phalanx of finger 0.6646479939439767 0.4495655850628872 0.6530237077802297 1.0 1.0 2 O60828 1 +Impaired vibratory sensation 0.3722043909221614 0.4486679162303162 0.6536712324608613 1.0 1.0 22 Q9Y619,Q9NR77,O14773 3 +Abnormality of the mitochondrion 0.3221584233313591 0.4464999837441026 0.6552361243429212 1.0 1.0 71 P12235,Q4J6C6,Q16836,P11177,Q13501,Q9UBX3,P20674,P35637,Q3ZCQ8,O96000,O00429,P00403,Q00325,Q9NPL8,O43772,Q70HW3,P23786,Q96CU9,O75306,O43676,P40939 21 +Ectopia lentis 0.559257856872386 0.4455159950788564 0.6559469032561966 1.0 1.0 3 O75533,Q99496 2 +Abnormality of the metacarpal bones 0.3795342861844498 0.4429916669192188 0.6577717621270414 1.0 1.0 34 P16278,P51798,P10644,P48651,P08236,Q32P28,Q14739,P16435,Q9UBM7,O60828 10 +Emg abnormality 0.3340217544872341 0.4413252269245614 0.6589775655906025 1.0 1.0 67 Q13510,P12235,Q14126,O15270,P50402,Q16637,O15269,O43681,P07602,O95140,Q13501,Q9NR77,P22626,O14773,Q9NZJ7,P51114 16 +Tachycardia 0.3709588215099402 0.4405202388087181 0.6595603572201894 1.0 1.0 22 Q14126,O43772,P23786,P42892 4 +Nonprogressive 0.4683545452878364 0.436681636333787 0.6623422488031061 1.0 1.0 6 Q9NQZ5 1 +Headache 0.3465471373020797 0.4335065552257296 0.6646468048386711 1.0 1.0 62 Q8TAA9,P23786,P04062,P01889,P10644,O00429,P05067,Q9NQW6,Q9NQZ5,Q9NZ08 10 +Irritability 0.3240568778786327 0.4316032892984854 0.6660297673753779 1.0 1.0 70 Q13510,P01889,P50897,P07602,Q15067,Q13501,Q9NQW6,Q5KU26,Q06787 9 +Abnormal full field electroretinogram 0.4377614397841277 0.4308616497441792 0.6665689699080002 1.0 1.0 8 P50897 1 +Abnormal light and dark adapted electroretinogram 0.4377614397841277 0.4308616497441792 0.6665689699080002 1.0 1.0 8 P50897 1 +Abnormality of the musculature of the thigh 0.4519972606724208 0.4279771079586535 0.6686677870576501 1.0 1.0 7 P50402,O14979 2 +Abnormality of female external genitalia 0.373238288001702 0.4276584380293285 0.6688998133010222 1.0 1.0 26 P10644,P51809,Q15392,Q9Y619,Q9UBM7 5 +Inability to walk 0.3102226863194495 0.4260309497182276 0.670085293914922 1.0 1.0 74 Q13510,P12235,O75503,O15270,Q96N66,O75787,O14949,Q96CU9,O15269,O00429,Q15041,O95140,Q99720,Q9NR77,O00592,P35637 16 +Abnormal leukocyte physiology 0.3652561918400098 0.4258810037663419 0.6701945576238115 1.0 1.0 52 O75787,P02786,P28070,Q14108,Q15904,O00754 6 +Arthralgia 0.3768514442711754 0.4251443913483145 0.6707314190252922 1.0 1.0 33 Q13510,P01889,P06280,O95140,Q9Y4P3,P28070,P35670,Q9NZ08 8 +Abnormal morphology of the radius 0.3886296717775999 0.4240591347157248 0.6715226872802922 1.0 1.0 12 P10644,Q32P28 2 +Aplasia hypoplasia of the ribs 0.364134469518349 0.4230362534889263 0.6722688106364889 1.0 1.0 19 Q8TAA9,Q14739,Q9BV10,Q9Y619,Q9UHX1 5 +Dyspnea 0.3214082374636119 0.4227475314138679 0.6724794725231997 1.0 1.0 84 Q13510,P23786,P04062,P10253,P01889,P06280,P07602,Q13501,O75844,Q9Y619,P35637,Q92804,Q9UHX1 13 +Exanthem 0.5513063233623505 0.4211227662084004 0.6736654380560092 1.0 1.0 3 Q01130,Q03426 2 +Abnormal anterior horn cell morphology 0.4642354405076708 0.4206831457315113 0.673986470051867 1.0 1.0 6 Q13510 1 +Retinal dysplasia 0.450058044567728 0.4199781149538476 0.6745014413508708 1.0 1.0 7 Q10713,P52732,O43505 3 +Abnormality of the plantar skin of foot 0.376337361244895 0.4192464108416999 0.6750360567548159 1.0 1.0 37 P53634,Q9Y487,P07858,Q06136 4 +Abnormal hdl cholesterol concentration 0.4890286733158925 0.4157835147750066 0.677568422936091 1.0 1.0 4 P38571 1 +Joint hemorrhage 0.6529144587433706 0.4146135089466005 0.6784248573217824 1.0 1.0 2 P49257 1 +Hypoparathyroidism 0.4050634371139173 0.4134549223965093 0.6792733423885691 1.0 1.0 10 Q08J23,P21964,P00403,P40939,P35670 5 +Short ribs 0.4178973800266648 0.4112267617298131 0.6809062666332442 1.0 1.0 9 Q9Y619,Q14739 2 +Olivopontocerebellar hypoplasia 0.4863636363636476 0.4069499370510994 0.6840447579457074 1.0 1.0 4 Q9Y5P6,Q9UNW1,P30153 3 +Abnormal abdomen morphology 0.4138086583165556 0.4066326492966984 0.6842778138064416 1.0 1.0 181 Q13510,P07602,P15586,Q01844,Q9Y619,Q14108,Q9NZ08,O96000,Q10713,P16278,P01889,O75787,P21964,P61916,O75845,Q14739,P54802,P04062,P10619,Q15392,Q16625,P04066,O43772,P28070,P23786,P38571,P10253,Q96CU9,O75306,O43676,P08236,Q15067,Q07021,P07686,O15118,Q15904,O00754 37 +Encephalocele 0.4030682261467785 0.4034945433212944 0.6865844481575094 1.0 1.0 10 O43505 1 +Abnormality of tibia morphology 0.3845423222706572 0.4016292652647027 0.6879568887598393 1.0 1.0 12 Q9BV10,P16435,Q32P28 3 +Posteriorly rotated ears 0.3182863639696912 0.3990304974324994 0.6898707328385019 1.0 1.0 83 P23786,P04062,P11233,Q10713,Q15555,Q8NCH0,Q15392,Q9Y4P3,P42892,Q9Y619,Q9UBM7,Q9UHX1,O43505 13 +Broad based gait 0.3583566714106568 0.3964586596718835 0.6917666993970542 1.0 1.0 18 P04062,O14773,Q9Y5P4 3 +Morphological abnormality of the pyramidal tract 0.3599150067902781 0.3962578931350426 0.6919147866177249 1.0 1.0 19 P11177,Q13501,Q9Y4P3,Q9Y619,P35637,O75569 6 +Central scotoma 0.4293768571742268 0.3941964196263175 0.6934360288634038 1.0 1.0 8 O75306,Q9H061,O00429,Q9H6K4 4 +Epidermal acanthosis 0.4291539739362818 0.3932307464440733 0.6941490627015372 1.0 1.0 8 Q14574 1 +Abnormal t cell proliferation 0.6445874337622954 0.3906567616105768 0.6960509632549963 1.0 1.0 2 P17812 1 +Severe varicella zoster infection 0.6445874337622954 0.3906567616105768 0.6960509632549963 1.0 1.0 2 P17812 1 +Reduced antigen specific t cell proliferation 0.6445874337622954 0.3906567616105768 0.6960509632549963 1.0 1.0 2 P17812 1 +Vocal cord paralysis 0.3655261855781881 0.3863138428317524 0.6992642496639179 1.0 1.0 16 P50402,Q9NR77 2 +Abnormal clavicle morphology 0.3576543232642359 0.381988881633143 0.7024696116153348 1.0 1.0 19 Q9Y619,O75844 2 +Cerebellar atrophy 0.3440512727463313 0.3819114521508466 0.7025270454336128 1.0 1.0 108 P12235,O75503,Q5JRX3,Q13501,Q8N2K0,Q14108,Q6DKK2,Q06787,O75208,Q10713,O75787,P51798,O00429,O75845,Q5XKP0,Q8IV08,Q9Y320,O14773,Q9H6K4,Q96CU9,O00754 21 +Limb dystonia 0.3730252803702591 0.3815634895843881 0.7027851698753764 1.0 1.0 14 Q99720 1 +Pain insensitivity 0.5378865139605361 0.3813921318327174 0.7029122985134943 1.0 1.0 3 O15269 1 +Abnormal pulmonary interstitial morphology 0.3682711974272294 0.3782109356385646 0.7052739023305981 1.0 1.0 29 Q13510,Q14108,Q8IZA0 3 +Hypoproteinemia 0.6400454201362545 0.3778978664656345 0.7055064674442828 1.0 1.0 2 Q9UJS0 1 +Abnormality on pulmonary function testing 0.3549151988130994 0.3749177102823432 0.7077216673001305 1.0 1.0 18 P16278 1 +Pace of progression 0.366610611355283 0.3745088692696282 0.7080257592052241 1.0 1.0 131 Q13510,P12235,O95831,O00584,Q13126,Q13501,P15586,P07196,Q14108,Q10713,O75787,O00429,O75477,P54802,Q5XKP0,Q8IV08,O14773,O95470,O14979,P04062,P50402,Q16637,Q99720,Q9NR77,Q9NQZ5,O95140,O75569 27 +Leukodystrophy 0.3660385095200575 0.3734027257015977 0.7088487311542355 1.0 1.0 46 O96000,Q96CU9,O75306,O43676,O43681,P07602,Q15067,Q9NPL8 8 +Abnormality of thalamus morphology 0.3750790009415179 0.3709161552079041 0.7106999820124613 1.0 1.0 13 O43819,O75306,Q969G3,Q9Y5P6,Q12824 5 +Patellar hypoplasia 0.6373959121877306 0.3705580486673658 0.710966733158044 1.0 1.0 2 Q8N806 1 +Fatty replacement of skeletal muscle 0.4508924221248827 0.369869613842488 0.7114796430297683 1.0 1.0 6 P22626 1 +Aplasia hypoplasia involving the nose 0.3643819578933648 0.368489376098527 0.7125083653758972 1.0 1.0 26 Q08J23,P10644,Q8TC12,O75844,Q5KU26,P55795 6 +Distal lower limb amyotrophy 0.3816046012885182 0.3657384552928284 0.7145602480617881 1.0 1.0 11 O95140,Q9NR77 2 +Malabsorption 0.3641699929868847 0.3655836780755835 0.7146757562491326 1.0 1.0 47 O76024,P14174,P38571,P01889,Q08J23,P09601,Q01130,P06280,Q9Y3E5,Q96A33,Q14739,Q9Y4P3,P48506,O95453,P18074,Q8N5K1,Q9NZ08 17 +Abnormal liver morphology 0.4165238556103915 0.3654791375921957 0.7147537771256962 1.0 1.0 189 Q13510,Q16836,P07602,P15586,Q01844,Q9Y619,Q14108,P22626,O96000,P11717,Q10713,P16278,O75787,P61916,O75845,Q14739,P54802,Q5XKP0,P04062,P10619,Q16625,P04066,P53634,O43772,P28070,P38571,P23786,P10253,Q96CU9,Q8N511,O43676,P08236,O75306,Q15067,Q07021,P07686,O15118,Q15904,O00754 39 +Abnormal heart valve physiology 0.314893137263334 0.3636745507163073 0.7161010494931792 1.0 1.0 71 P04062,P16278,P01889,O75306,P10644,P06280,O75844,Q9UHX1,Q15904,O00754,Q9NZ08 11 +Abnormal myocardium morphology 0.368076145003225 0.3580477731135157 0.7203075624462434 1.0 1.0 134 Q16836,P06280,P15586,Q14108,P22626,Q9NZ08,O96000,Q14126,P16278,P01889,Q9H061,P54802,Q5XKP0,P04062,P50402,Q9Y4P3,O43772,P23786,P10253,Q96CU9,O75306,O43676,P08236,Q07021,P48735 25 +Optic neuropathy 0.3647973188491456 0.3575874238104487 0.7206520911746521 1.0 1.0 15 O96000,Q96CU9,O43676,O75306 4 +Cholecystitis 0.4060901472303141 0.3568079132625089 0.7212356117763101 1.0 1.0 9 O43681,P07602 2 +Central hypothyroidism 0.3936014458016036 0.3568044412669913 0.7212382111819766 1.0 1.0 10 O14654,Q969G3,Q12824,Q99496 4 +Molluscum contagiosum 0.629825889477662 0.3500135114159268 0.7263285576159388 1.0 1.0 2 O95394 1 +Unusual skin infection 0.629825889477662 0.3500135114159268 0.7263285576159388 1.0 1.0 2 O95394 1 +Tapered finger 0.3662221519818121 0.3476831346066737 0.728078164014609 1.0 1.0 34 P23786,Q15555,Q8NCH0,Q06136,Q96EK5,P42892 6 +Disseminated intravascular coagulation 0.4446168439458866 0.3465471603682259 0.7289315483873811 1.0 1.0 6 P38571 1 +Spastic tetraplegia 0.3657003373791978 0.3461807436951076 0.7292068853829325 1.0 1.0 33 P04066,P16278 2 +Progressive gait ataxia 0.3777001639835456 0.3452580188940151 0.7299004044295561 1.0 1.0 11 P07602 1 +Progressive 0.3136982853034936 0.3444438850527158 0.7305124901324833 1.0 1.0 83 Q13510,P12235,P04062,Q13126,Q16637,O00429,O75477,Q99720,Q13501,P15586,P54802,Q5XKP0,O75569,O95470 14 +Sparse or absent eyelashes 0.3527021138239388 0.3411663240495974 0.7329783735598736 1.0 1.0 20 O75844 1 +Aggressive behavior 0.3272247194469052 0.3400026668810184 0.7338545195692352 1.0 1.0 66 Q10713,O75503,O00462,P35270,Q13501,P54802,P35670,Q9UBM7,P55795,Q6DKK2,Q06787 11 +Death in childhood 0.3509086593066827 0.339766219488662 0.7340325890238508 1.0 1.0 19 P07686,Q9NPL8,P20674,Q96IX5,O60828 5 +Aplasia hypoplasia involving bones of the thorax 0.3623440391768396 0.3379627226367745 0.7353912796190607 1.0 1.0 29 Q8TAA9,Q14739,Q9BV10,O75844,Q03164,Q9Y619,Q9UHX1 7 +Profound hearing impairment 0.4420729492263935 0.3372055371702033 0.7359619634409551 1.0 1.0 6 Q9NR77 1 +Arnold chiari malformation 0.3487544821926878 0.3367086063540241 0.736336574914255 1.0 1.0 18 Q8TAA9,Q9Y4P3,O00754,O75845 4 +Choanal stenosis 0.4639102267814903 0.3355730844455224 0.7371928236569858 1.0 1.0 4 P48651,P16435 2 +Myoclonic seizure 0.3638335785965328 0.3354611634187533 0.7372772362233522 1.0 1.0 42 Q13510,P04062,P16278,O75503,P07602,P07686,Q9Y619 7 +Abnormal blistering of the skin 0.3500694530328092 0.334553067602317 0.7379622532065016 1.0 1.0 19 P01889,P51798,Q06136,Q14574,Q9NZ08 5 +Abnormality of facial musculature 0.3123309856296983 0.3345349600920176 0.7379759146235334 1.0 1.0 71 Q13510,P12235,O43819,P48651,Q9Y3E5,Q13501,P07196,O75787,P51798,O00429,O00592,Q9UHX1,P04062,P35270,Q12824,P10253,Q969G3,Q9Y5P6,O00754 19 +Spinal cord compression 0.5210147671336552 0.3341872503078669 0.7382382642711096 1.0 1.0 3 Q9UNW1,P51530 2 +Abnormality of the skull base 0.3590619687455217 0.3317243055536273 0.7400974457694323 1.0 1.0 48 P23786,Q9Y487,Q14739,Q9UBM7,O00754,O43505 6 +Abnormality of circulating enzyme level 0.3113855006078824 0.3303555558481445 0.7411313194051001 1.0 1.0 82 P23786,Q14126,P10253,O14979,Q16836,O95831,P12235,P50402,Q5JRX3,Q9NWM8,P53985,Q13501,Q07021,Q9Y4P3,O43772,P22626,O43505 17 +Abnormal circulating non proteinogenic amino acid concentration 0.440008756838129 0.329674712848816 0.7416457627183937 1.0 1.0 6 P05067 1 +Scapular winging 0.3535420363596472 0.3282526599499295 0.7427206346808135 1.0 1.0 22 Q13501,O00429,Q9Y487,P50402 4 +Eeg with abnormally slow frequencies 0.3556609443315592 0.3280231878849951 0.7428941303603924 1.0 1.0 16 Q13501,O75503 2 +Metaphyseal widening 0.3631914946179974 0.3262465534913199 0.7442378218946208 1.0 1.0 14 P16278 1 +Polycystic liver disease 0.5179856115107908 0.3260540116890725 0.7443834906036673 1.0 1.0 3 Q9UGP8,Q14697 2 +Cystic liver disease 0.5179856115107908 0.3260540116890725 0.7443834906036673 1.0 1.0 3 Q9UGP8,Q14697 2 +Abnormality of facial soft tissue 0.3359261143055468 0.3238580235103332 0.7460455250158429 1.0 1.0 105 Q13510,P12235,O43819,P48651,Q9Y3E5,Q13501,P07196,O75787,P51798,O00429,O75844,O00592,Q9UHX1,Q9UBM7,P04062,P35270,Q9Y4P3,Q9NQW6,P28070,Q12824,P10253,Q969G3,Q9Y5P6,P16435,O00754 25 +Hyperacusis 0.4119021052024831 0.320043881358697 0.7489350660379714 1.0 1.0 8 P17900 1 +Sound sensitivity 0.4119021052024831 0.320043881358697 0.7489350660379714 1.0 1.0 8 P17900 1 +Scleral staphyloma 0.4574283002278926 0.3160521970872668 0.7519628895180155 1.0 1.0 4 Q969N2,P40939 2 +Localized osteoporosis 0.6165783497350427 0.3156272762822182 0.7522854317506109 1.0 1.0 2 P57740 1 +Chest pain 0.3612200015138326 0.3153049186590602 0.7525301507899553 1.0 1.0 14 P10644,P01889,Q99496 3 +Hepatic encephalopathy 0.5130632336236305 0.3130677888816893 0.7542291606087088 1.0 1.0 3 P09622,Q9UJS0 2 +Absent septum pellucidum 0.3591667496021906 0.3117479876566702 0.7552320551655585 1.0 1.0 30 O43505,Q15392 2 +Somatic mutation 0.3606842537324557 0.3085834503322361 0.7576384115830144 1.0 1.0 34 P11717,Q92733,O75874,Q01844,Q92804 5 +Spastic gait 0.3471982849707585 0.3068614496952555 0.7589488329743896 1.0 1.0 20 Q9Y619,O75477,O75787 3 +Abnormal activity of mitochondrial respiratory chain 0.3606506602309369 0.3049935227463679 0.7603710855486217 1.0 1.0 39 O96000,Q96CU9,O75306,O43676,Q9UBX3,Q70HW3 6 +Abnormal astrocyte morphology 0.3624336157227858 0.3019680505243602 0.762676418683129 1.0 1.0 13 Q13501,P48735 2 +Abnormal immune system morphology 0.3534083742444925 0.3014580051029794 0.7630652684420689 1.0 1.0 124 Q13510,Q14126,P04062,Q8TAA9,P16278,P01889,P02786,O75787,P61916,Q14739,P04066,P53634,O15118,P28070,Q14108,Q15904,O00754 17 +Microdontia 0.3489818018195941 0.2994603708277439 0.7645888049042431 1.0 1.0 22 Q9Y619,Q9Y4P3,Q96A33,Q9Y487 4 +Neuronal loss in basal ganglia 0.5077341767998149 0.2993359279945217 0.764683743987816 1.0 1.0 3 O75306 1 +Central adrenal insufficiency 0.431602879878751 0.2988346335447162 0.7650662239585648 1.0 1.0 5 Q9NSE4,Q9NRG9,O00170,P35222 4 +Deviation of the 2nd finger 0.4503950240612153 0.29546037267425 0.7676422198016628 1.0 1.0 4 Q9H6K4 1 +Overlapping fingers 0.4055530018383114 0.2939546927652662 0.7687925244962872 1.0 1.0 8 Q2VPK5 1 +Choroid plexus cyst 0.6074943224829606 0.2932411959114714 0.7693377976010911 1.0 1.0 2 P07954 1 +Developmental regression 0.3364167074866481 0.2929756720289331 0.7695407470965687 1.0 1.0 108 Q13510,O75503,P06280,P07602,Q9NZ08,P16278,P01889,O00429,O14773,O95470,O43681,Q9Y4P3,Q9H2C2,P55795,P17900,O75306,Q15067,P07686,Q9NZJ7 19 +Hydrops fetalis 0.3590212197913974 0.2926447167607633 0.7697937302661133 1.0 1.0 37 Q13510,P16278,P10619,P08236,Q14739 5 +Thick lower lip vermilion 0.3588003528650237 0.2925146146061355 0.7698931874424582 1.0 1.0 40 P15586,P06280,P04066 3 +Noncompaction cardiomyopathy 0.504733055660728 0.2917549937170406 0.7704739585592011 1.0 1.0 3 P31040,Q15233 2 +Abnormal cerebral vascular morphology 0.3433619232103441 0.2877223347414279 0.7735592919927152 1.0 1.0 56 P23786,P06280,O75844,P05067 4 +Abnormality of the synovia 0.3079212534148426 0.2845049578140218 0.7760234351679438 1.0 1.0 71 Q9Y487,P16278,P08236,O75844,Q9UHX1,Q9UBM7 6 +Status epilepticus 0.3575261802905017 0.2843250981825403 0.7761612539176019 1.0 1.0 35 Q13510,Q9Y487,P07602,Q15392,P42892 5 +Abnormal pulmonary thoracic imaging finding 0.3400309898607767 0.2834738898152252 0.7768135940535588 1.0 1.0 18 Q13510,P04062,P01889,Q9NZ08 4 +Wide nasal ridge 0.4461723533967541 0.2834015531409762 0.776869037938535 1.0 1.0 4 P61978 1 +Abnormal glomerular mesangium morphology 0.3515265372534854 0.2821681384682828 0.7778145878859404 1.0 1.0 15 Q9NQW6 1 +Abnormality of the lymph nodes 0.3552818107924938 0.2810534703894586 0.7786693884895008 1.0 1.0 31 Q13510,P14174,P01889,P10644,Q01844,P28070,Q9NZ08 7 +Distal sensory loss of all modalities 0.4446503377811693 0.279112256189469 0.7801586776774829 1.0 1.0 4 O15269 1 +Progressive microcephaly 0.3568269379181215 0.2778167973633338 0.7811529961535457 1.0 1.0 36 P50897,Q5KU26,Q9Y487 3 +Furrowed tongue 0.4435606060606182 0.2760600250595003 0.7825019633957488 1.0 1.0 4 Q9H2M9,P61978,P21912 3 +Abnormality of the thoracic cavity 0.3765018452000098 0.2751846376425241 0.7831743889018259 1.0 1.0 10 Q969G3,Q12824,P01889,Q01844 4 +Irregular menstruation 0.4236225018906246 0.2731483301382842 0.7847391966595398 1.0 1.0 5 Q06787 1 +Aplasia hypoplasia of the lungs 0.3516342355668036 0.2720470477667939 0.7855858441504928 1.0 1.0 28 Q8TAA9,Q14739,Q9UBM7,O75844 4 +Abnormality of the phalanges of the hallux 0.4960242332449727 0.2703902336986146 0.7868600527607885 1.0 1.0 3 Q6DKJ4,Q2M1P5 2 +Abnormality of the proximal phalanx of the thumb 0.4960242332449672 0.2703902336986016 0.7868600527607985 1.0 1.0 3 Q15233,O60828 2 +Cerebellar malformation 0.3481180148776344 0.2676934872288989 0.7889352633558189 1.0 1.0 51 P23786,Q9Y487,O75845,Q9UBM7,O00754,O43505 6 +Delayed puberty 0.3527981828479854 0.2675370814110985 0.7890556674698326 1.0 1.0 46 P04062,P06280,P51809,O75844,Q14108 5 +Distal peripheral sensory neuropathy 0.4947614973518803 0.2673718546388446 0.7891828675915331 1.0 1.0 3 P40939 1 +Renal insufficiency 0.3224213876562584 0.2638636321476728 0.791885000086848 1.0 1.0 65 Q8TAA9,P23786,Q10713,P01889,P06280,Q16625,Q9NQW6,Q14108,O95470,Q9NZ08 10 +Cranial nerve compression 0.3737508535044732 0.2624227867720669 0.7929955067897059 1.0 1.0 10 P51798,P22626,Q02978 3 +Perisylvian polymicrogyria 0.4911018553578189 0.2587392228736534 0.7958364542932446 1.0 1.0 3 Q9BVA1,P34897 2 +Ventricular arrhythmia 0.3511157445987711 0.2576884001438124 0.796647399189804 1.0 1.0 30 Q14126,P23786,P10253,P50402,O75306,P42892,O43772 7 +Meningioma 0.4186217333851396 0.2544450612790506 0.7991517422920351 1.0 1.0 6 Q969G3,Q12824 2 +Fibrous tissue neoplasm 0.3390675585094116 0.2542867714681245 0.7992740188363128 1.0 1.0 17 Q13126,P10644,Q15392,Q969G3,Q12824 5 +Increased serum iron 0.4889036583585939 0.2536368474412441 0.7997761271219626 1.0 1.0 3 Q02241 1 +Hypolipoproteinemia 0.4182500704871498 0.2531857947427876 0.8001246431327997 1.0 1.0 6 Q10471,P38571 2 +Progressive leukoencephalopathy 0.4880726997349356 0.2517243582074457 0.8012541280027821 1.0 1.0 3 P31040,Q9Y263 2 +Abnormality of hair texture 0.351553104429595 0.2483434813956334 0.8038686592026512 1.0 1.0 44 P15586,O75844,P54802 3 +Abnormality of chromosome stability 0.3704601851722037 0.2473045659834972 0.8046725253780411 1.0 1.0 10 P33991,Q99496,Q969G3,Q12824,Q06787 5 +Polycythemia 0.587055261165776 0.2465683220852271 0.805242323012088 1.0 1.0 2 P07954 1 +Central hypoventilation 0.4146887103044694 0.2453760304269062 0.8061652867379352 1.0 1.0 5 O75306 1 +Glomerular sclerosis 0.3465042646498268 0.2450051903865374 0.8064524124772374 1.0 1.0 27 Q14108,Q9NQW6 2 +Gowers sign 0.3544938848588716 0.2429833359174227 0.808018306671906 1.0 1.0 12 Q13510,P07196 2 +Abnormal globus pallidus morphology 0.4151780614520614 0.242844169433358 0.80812611727844 1.0 1.0 6 O75306 1 +Myopathic facies 0.4144284061825235 0.2403388397308759 0.8100675874708041 1.0 1.0 6 Q9Y5P4 1 +Abnormal odontoid tissue morphology 0.3503827876125685 0.2400936584721632 0.810257650260626 1.0 1.0 33 P16278,P21964,Q9Y4P3,Q6P4Q7,Q9UBM7 5 +Abnormality of the ureter 0.3447112081075614 0.2391094284358947 0.8110207309709438 1.0 1.0 51 Q8TAA9,P23786,P21964,O95630,Q9Y4P3,Q86XL3,O75844,Q9UHX1,Q9UBM7 9 +Lower limb hypertonia 0.3790166567089358 0.2382609854210529 0.8116786791859343 1.0 1.0 9 Q14739 1 +Abnormal waist to hip ratio 0.4137265326753332 0.2379997784781712 0.8118812660155825 1.0 1.0 6 P18031,Q9Y6M1,O76024 3 +Achilles tendon contracture 0.3683194603799969 0.2375582876901902 0.8122237059813668 1.0 1.0 10 P50402,Q8N2K0,Q9Y3E5 3 +Abnormal renal tubule morphology 0.3337017806054358 0.2349142220427259 0.8142753108277698 1.0 1.0 19 P23786,P06280,O75306 3 +Cardiac arrest 0.3435853427842474 0.2332991341174723 0.8155291309319617 1.0 1.0 26 Q14126,P04062,P01889,P50402,O43772,P04899 6 +External ear malformation 0.3672688589813691 0.2328013433517124 0.8159156697394132 1.0 1.0 10 Q8NCH0 1 +Kinetic tremor 0.3476881493673917 0.2300555867578639 0.8180485759033362 1.0 1.0 31 O43681,P07602,Q14108,Q9NZJ7,Q06787 5 +Oral ulcer 0.3894045018673778 0.2299424071559147 0.818136522944845 1.0 1.0 8 P01889 1 +Membranoproliferative glomerulonephritis 0.5787282361847028 0.2290612140539838 0.8188213387215857 1.0 1.0 2 O95394 1 +Recurrent paroxysmal headache 0.3889359681910844 0.2281391056650263 0.8195380996647503 1.0 1.0 8 P10644,P00403 2 +Abnormal tricuspid valve physiology 0.3369589512974152 0.2212793112162544 0.8248749579782668 1.0 1.0 16 P53701,P10644,Q99496,P40939,Q15904 5 +Abnormality of pancreas physiology 0.3444687298937813 0.2193666352772854 0.8263644582457845 1.0 1.0 29 P14174,P01889,P09601,Q9Y3E5,P53985,Q14739,P48506,Q9UHX1,Q15904,Q9NZ08 10 +Ridged nail 0.4218410619919269 0.2186210513388318 0.8269452528626389 1.0 1.0 4 P16615 1 +Osteomyelitis 0.3465189434662052 0.2184650383453903 0.8270667957776321 1.0 1.0 13 P51798,Q13126,O15269,O15270 4 +Renal agenesis 0.3463086826104354 0.2164648549069106 0.828625417442638 1.0 1.0 46 Q8TAA9,Q2VPK5,O75306,Q15392,Q86XL3,Q9UHX1,Q9UBM7 7 +Increased circulating acth level 0.4716493723272964 0.2157889929156703 0.8291522285771757 1.0 1.0 3 P16435 1 +Hyperinsulinemic hypoglycemia 0.4046997893596435 0.2156212291045787 0.8292830065998631 1.0 1.0 5 P00367,Q16836,P53985 3 +Arthrogryposis multiplex congenita 0.3417746510901356 0.2147432481925404 0.8299675018954502 1.0 1.0 27 P04062,O75844,Q15392 3 +Abnormality of the breast 0.3038565304971397 0.2147426846712851 0.8299679412718417 1.0 1.0 84 P23786,Q9Y5P4,Q15555,P10644,Q15067,P51809,Q96EK5,O75874,Q9Y619,Q96A33,Q9UBM7,P48735,Q06787 13 +Premature ventricular contraction 0.4039141275096607 0.2133411858247087 0.8310608512710158 1.0 1.0 5 Q14126 1 +Late onset 0.3850531107739006 0.2133190508770115 0.831078115065099 1.0 1.0 8 P18031,O76024,P17096,P31751,P31930,P62263,Q9Y6M1 7 +Abnormal synaptic transmission at the neuromuscular junction 0.3400961063518545 0.2112578696652036 0.8326860561082698 1.0 1.0 26 Q92734,P43243,Q15165,P50995,Q13501,Q9Y5P6,O75340,P35637,Q92804 9 +Abnormality of the ankles 0.3475798462266544 0.2110662694217742 0.8328355603958868 1.0 1.0 37 O75787,P07602,Q9Y4P3,O75844,O95140,O00754 6 +Abnormally folded helix 0.33834132857063 0.2098758312315535 0.8337645860050533 1.0 1.0 15 P23786 1 +Distal amyotrophy 0.3444827854235766 0.2074035937583417 0.8356946762081061 1.0 1.0 47 Q13510,O15270,O15269,P51149,O95140,Q13501,Q99720,Q9NR77,P07196,Q8N2K0,P35637,Q8N0X7 12 +Anteriorly placed anus 0.3712419649047753 0.2061210853706313 0.8366963286592874 1.0 1.0 9 P53701,P48651,Q15022,P16435 4 +Hepatic fibrosis 0.3377748116456717 0.2044052311693543 0.8380368426035769 1.0 1.0 25 Q13510,P38571,P04062,Q15904 4 +Abnormality of the cervical spine 0.3094852997938701 0.203115715713483 0.8390445883961 1.0 1.0 90 P16278,P50402,P08236,Q8NCH0,P15586,P04066,Q9UHX1,Q9UBM7,O00754 9 +Abnormal blood sodium concentration 0.3599824633705782 0.20030338001773 0.8412433192446946 1.0 1.0 10 Q13423,Q9BV10,O95551 3 +Patent ductus arteriosus 0.3031134109220577 0.1981478058489574 0.8429294226116495 1.0 1.0 70 Q2VPK5,Q9NWM8,Q15392,O75844,P42892,Q9UBM7 6 +Abnormal circulating sex hormone concentration 0.3291326448810679 0.1975154402603462 0.8434241998539365 1.0 1.0 20 Q13423,P51809,Q969G3,P16435,Q12824 5 +Papule 0.3359148106125542 0.1969018190418387 0.843904370157605 1.0 1.0 15 O75844,P01889 2 +Premature birth 0.3449261222033032 0.1966669006856363 0.8440882136179229 1.0 1.0 35 O43676,Q9UBM7,O75844 3 +Corneal neovascularization 0.4127194711320062 0.1965075163798425 0.8442129501394047 1.0 1.0 4 P21964 1 +Lower limb amyotrophy 0.3420064798431131 0.1955609874252484 0.8449537981267046 1.0 1.0 13 Q92734,O95140,Q9NR77,P07196 4 +Protruding tongue 0.3801213960546288 0.1948241648328749 0.8455306039616652 1.0 1.0 8 O60826,Q10713,O15111,Q6NUK1,Q9C0B1,P67870,P20700 7 +Delayed cranial suture closure 0.3396891900838065 0.1947901124086344 0.8455572631791652 1.0 1.0 28 Q9Y487,O75844,O75718,Q32P28 4 +Non midline cleft palate 0.5609386828160403 0.1946477043005123 0.8456687546235881 1.0 1.0 2 O60716 1 +Bilateral cleft lip and palate 0.5609386828160403 0.1946477043005123 0.8456687546235881 1.0 1.0 2 O60716 1 +Bilateral cleft palate 0.5609386828160403 0.1946477043005123 0.8456687546235881 1.0 1.0 2 O60716 1 +Absent distal phalanges 0.5609386828160403 0.1946477043005123 0.8456687546235881 1.0 1.0 2 Q6NUK1 1 +Abnormal atrioventricular valve morphology 0.340535525848867 0.1939463259054717 0.8462179094940034 1.0 1.0 29 P04062,P21964,Q9Y4P3,O75844,Q06787 5 +Vocal cord paresis 0.4605691060268285 0.1935849692718523 0.8465008683365771 1.0 1.0 3 O95140 1 +Genital neoplasm 0.3413106813218692 0.1932032095304211 0.8467998252516329 1.0 1.0 30 P10644,P51809,O75874,Q01844,P48735 5 +Abnormal muscle fiber protein expression 0.3957325077952869 0.1901370625740577 0.8492017280593502 1.0 1.0 5 P50402 1 +Nonimmune hydrops fetalis 0.331133473554672 0.1898638483827248 0.8494158219433323 1.0 1.0 22 P10619,Q14739,P04062 3 +Abnormality of the dorsal column of the spinal cord 0.4577811435062391 0.1882606147737173 0.8506723581282514 1.0 1.0 3 Q8WVX9,Q6PI48 2 +Broad foot 0.3885619973482666 0.1872345083639224 0.8514767694762422 1.0 1.0 7 O95831,O00170 2 +Emg myopathic abnormalities 0.3321734809126756 0.186975268270792 0.8516800240310063 1.0 1.0 23 P12235,P50402,Q13501,P22626,P51114 5 +Aplasia hypoplasia involving forearm bones 0.3272209449161533 0.1867468063019919 0.8518591554784491 1.0 1.0 17 P10644,Q9UBM7 2 +Abnormality of the maxilla 0.3368933934858775 0.1839233406274937 0.8540735939836841 1.0 1.0 27 Q9Y619,Q14739,O95630,Q96EK5 4 +Male pseudohermaphroditism 0.4547519878833815 0.1825958418615359 0.8551151472060257 1.0 1.0 3 Q14781,P53701 2 +Cervical spinal canal stenosis 0.5537471612414784 0.1818988705773996 0.8556620908606101 1.0 1.0 2 Q8IWS0 1 +Spondyloepiphyseal dysplasia 0.5537471612414753 0.1818988705773942 0.8556620908606143 1.0 1.0 2 P27635 1 +Stage 5 chronic kidney disease 0.3297689886941717 0.1817176677551255 0.8558042999580389 1.0 1.0 22 P23786,Q9NQW6 2 +Myoglobinuria 0.3446817151531099 0.180759646326394 0.8565562388281374 1.0 1.0 11 P23786,P40939,P46020,Q16836 4 +Underdeveloped supraorbital ridges 0.355426455020177 0.180441845807081 0.8568057052231353 1.0 1.0 10 P52732,P40855,Q08J23,Q6NUK1,P16435,O75381 6 +Frequent falls 0.3425370086159414 0.1803427911589418 0.8568834638617071 1.0 1.0 35 Q13510,P12235,P04062,Q9NVV4,O75787,O43681,P07602,P40939,Q9Y5P6,Q9NR77,O95140,Q9NZJ7 12 +Abnormal circulating bilirubin concentration 0.3337390727350652 0.1795126313112997 0.8575352000746614 1.0 1.0 25 Q14739,O75845,P23786 3 +Keratoconjunctivitis 0.3645718545330805 0.1793222786604182 0.8576846545365089 1.0 1.0 9 Q14739,P01889 2 +Elbow flexion contracture 0.3258536440080046 0.1782910812058007 0.8584943827668927 1.0 1.0 20 P23786,P50402,P48651,P37268,P16435 5 +Elevated total serum tryptase 0.5510976532929514 0.1773707742538503 0.8592171620899443 1.0 1.0 2 Q01130 1 +Anaphylactic shock 0.5510976532929514 0.1773707742538503 0.8592171620899443 1.0 1.0 2 Q01130 1 +Increased proportion of cd25 mast cells 0.5510976532929514 0.1773707742538503 0.8592171620899443 1.0 1.0 2 Q01130 1 +Abnormal mast cell morphology 0.5510976532929514 0.1773707742538503 0.8592171620899443 1.0 1.0 2 Q01130 1 +Hepatic cysts 0.5503406510219446 0.1760937061172689 0.8602203254544039 1.0 1.0 2 Q9UGP8 1 +Extrapyramidal muscular rigidity 0.3938367748251228 0.1744934957871962 0.8614776419665782 1.0 1.0 6 O75787 1 +Joint laxity 0.3201054427819826 0.1741460890108593 0.8617506527535026 1.0 1.0 62 P16278,Q9Y487,Q8NCH0,Q32P28,Q9Y4P3,Q9Y619,Q96A33,O00754,Q9UHX1,Q06787 10 +Kyphosis 0.3461702237559837 0.173557578384811 0.8622131734874086 1.0 1.0 128 P04062,P16278,Q9Y487,P01889,P50402,P08236,Q9NWM8,Q32P28,Q14739,Q9NR77,O75844,P04066,Q9UHX1,Q14108,Q9UBM7,Q5KU26,O00754 17 +Abnormal hepatic iron concentration 0.5454201362604001 0.167973053875085 0.8666044777481086 1.0 1.0 2 Q9Y276 1 +Abnormal sacrum morphology 0.33643165123041 0.1677266017059558 0.8667983675172282 1.0 1.0 29 O96028,Q8TAA9,P01889,Q08J23,P53701,O95202,Q14739,Q9Y4P3,P04066,Q03164,P61978 11 +Weakness due to upper motor neuron dysfunction 0.3245229602357363 0.1674134237774367 0.8670447635866592 1.0 1.0 107 Q13510,P07602,Q13501,Q9UBX3,Q9Y619,P35637,Q6DKK2,Q9NZ08,P01889,O75787,O00429,Q15041,Q5XKP0,P04062,O43681,P17900,Q9H6K4,Q96CU9,O75306,O95630,Q13423,Q9NZJ7,O00754 23 +Enlarged posterior fossa 0.3412485533951422 0.1673590580581292 0.8670875377117513 1.0 1.0 43 P23786,Q9UBM7,Q9Y487,O43505 4 +Contractures of the joints of the lower limbs 0.3392652670642592 0.1664252419450652 0.8678223107462499 1.0 1.0 47 P23786,Q99720,Q86XL3,Q8IZA0,P35637 5 +Oral cavity bleeding 0.39088972499863 0.1655637080238519 0.8685003098487583 1.0 1.0 6 P10644 1 +Melanocytic nevus 0.3609220545125703 0.1649780834673257 0.8689612325232756 1.0 1.0 9 P10644,Q96AY3,P18074 3 +Abnormal motor nerve conduction velocity 0.3231926817738472 0.1643914700793451 0.8694229781162504 1.0 1.0 17 Q9Y3E5,Q99720,Q9NR77,P07196,P51149,O95140 6 +Cystic hygroma 0.3816003216888917 0.1640321164041772 0.8697058609952135 1.0 1.0 7 Q14739,Q99567 2 +Abnormal lung development 0.3410844878356691 0.1632786019017879 0.8702990810103328 1.0 1.0 39 O96000,Q8TAA9,Q14739,O75844,Q9UHX1,Q9UBM7 6 +Periorbital edema 0.3278648836389189 0.1611671775414112 0.8719617316596415 1.0 1.0 23 P28070,Q9NQW6 2 +Neurogenic bladder 0.3849473323046009 0.1610994187808382 0.8720150980116965 1.0 1.0 5 Q8TAA9,Q8N5K1 2 +Abnormality of bladder morphology 0.3504963154738684 0.159369841197779 0.8733774984398646 1.0 1.0 10 Q9Y4P3,Q9NWM8 2 +Abnormal drinking behavior 0.4412481103056019 0.1588685066863819 0.8737724735486136 1.0 1.0 3 Q8N5K1 1 +Elevated circulating aspartate aminotransferase concentration 0.3499698185274428 0.1571462050336737 0.8751296235735158 1.0 1.0 10 Q15904 1 +Aplasia hypoplasia of the femur 0.3339811960763853 0.1557779385352589 0.8762080608103826 1.0 1.0 13 Q9UHX1,O95831,Q9BV10 3 +Axonal degeneration regeneration 0.4380458298622039 0.1536073037163381 0.8779193777603265 1.0 1.0 3 O95140 1 +Craniofacial dysostosis 0.4373050962071562 0.1524102089680373 0.8788634055524438 1.0 1.0 3 P10644 1 +Childhood onset sensorineural hearing impairment 0.5352006056018083 0.152100384692952 0.8791077607972819 1.0 1.0 2 Q9NSE4 1 +Prelingual sensorineural hearing impairment 0.5352006056018083 0.152100384692952 0.8791077607972819 1.0 1.0 2 Q9NSE4 1 +Abnormality of the nasal skeleton 0.391922001685376 0.1507646346661917 0.8801613847697636 1.0 1.0 4 P10644 1 +Facial edema 0.3272444114517715 0.1486093579883227 0.8818618884060458 1.0 1.0 24 P28070,Q9NQW6 2 +Gonadal dysgenesis 0.3566679490759795 0.148556394210102 0.8819036834790477 1.0 1.0 9 P51809 1 +Undetectable visual evoked potentials 0.4343703094356197 0.1477406621060748 0.8825474400274571 1.0 1.0 3 Q8TC12 1 +Hyperphenylalaninemia 0.5321725965177835 0.1476528498325853 0.8826167440369266 1.0 1.0 2 P09417 1 +Secondary microcephaly 0.3173259419988784 0.1474193355283485 0.8828010447126606 1.0 1.0 62 O75208,Q9Y487,Q9Y5P4,Q96CU9,P50897,O95630,Q9BV10,Q5XKP0,Q9UHX1,Q5KU26,P55795 11 +Recurrent otitis media 0.3201657149682442 0.1454651392918088 0.8843436377700129 1.0 1.0 20 Q9UBM7,Q06787 2 +Tetraparesis 0.3345299354957828 0.1440150444421382 0.8854885897329248 1.0 1.0 31 O95630,P07602,Q13501,P35637,P17900 5 +Aplasia hypoplasia of the uvula 0.4316546762589923 0.1435239129756156 0.8858764269277326 1.0 1.0 3 Q9NVI1,Q6DKJ4 2 +Chromosomal breakage induced by ionizing radiation 0.3871012191583958 0.1411109318224355 0.887782307722887 1.0 1.0 4 Q969G3,Q12824 2 +Muscle fibrillation 0.3280855752338736 0.1407420825654962 0.8880736988792113 1.0 1.0 14 Q13510,Q16637,P51114 3 +Knee flexion contracture 0.3272045793013148 0.1398918562618615 0.8887454357788698 1.0 1.0 25 P23786,P48651,O75477,P37268,Q86XL3,Q9Y5P6 6 +Gait imbalance 0.3166144793113636 0.1359297267791461 0.8918768350037891 1.0 1.0 19 Q9NR77,Q9Y4P3,O15269,O00592 4 +Hypoglycemic coma 0.3633047258163245 0.1347161289403827 0.8928363203921035 1.0 1.0 8 Q13423,P00367,Q16836 3 +Difficulty climbing stairs 0.3320631376889968 0.1339353846452755 0.8934536694556643 1.0 1.0 12 P12235,Q92734,O95140,P40939,Q9Y5P6,O75340 6 +Abnormality of the inner ear 0.3526208738467105 0.1332408943686678 0.8940028701255496 1.0 1.0 9 Q9Y619 1 +Anophthalmia 0.3718398930747476 0.1328024652298914 0.8943496046595465 1.0 1.0 7 O75569,O43505 2 +Bell shaped thorax 0.5208175624526816 0.1319992480256738 0.8949848865331436 1.0 1.0 2 Q96HY6 1 +Gastrointestinal hemorrhage 0.3294425208271578 0.1305973291354308 0.8960938556726106 1.0 1.0 28 P01889,P21964,Q14739,Q9UHX1,Q9NZ08 5 +Abnormal nipple morphology 0.3359561283908702 0.1302569564550139 0.8963631336337816 1.0 1.0 44 P23786,Q9Y5P4,Q15555,Q15067,Q96EK5,Q96A33,Q9UBM7 7 +Easy fatigability 0.3147466130343934 0.1254825055478213 0.9001415741138394 1.0 1.0 19 P12235,O95551,O00170,P10644,Q9NWM8,Q9Y5P6,P00338,P61978 8 +Scarring 0.3243133906023724 0.1226514083264801 0.9023831437723446 1.0 1.0 25 P04439,Q92542,Q9NWM8,P53634 4 +Abnormal blood gas level 0.4161302536917761 0.1213195406429145 0.9034379431411268 1.0 1.0 3 Q9Y3E5,P06753 2 +Keratitis 0.3411536519337643 0.1207105506853089 0.903920301870522 1.0 1.0 10 Q14739,P01889 2 +Short long bone 0.3225209298910685 0.1206855735608449 0.9039400860978524 1.0 1.0 24 Q9UHX1,P10644,P16278 3 +Abnormal forearm bone morphology 0.3180883668139267 0.1199569564982006 0.9045172454055002 1.0 1.0 16 P10644,Q9BV10,Q32P28 3 +Abnormality of the musculature of the upper limbs 0.3195616456544988 0.1172012996005262 0.9067005370859448 1.0 1.0 59 P12235,O14979,Q9NVV4,Q9Y487,P50402,O00429,P07602,Q13501,Q9NR77,P36551,P07196,O95140,Q9NZJ7 13 +Chordee 0.366211651742546 0.115058283171152 0.9083989254450536 1.0 1.0 5 P48651,P16435 2 +Zonular cataract 0.3396619753490499 0.1146996922787644 0.9086831578453172 1.0 1.0 10 O76024,Q9H6K4,Q99496 3 +Abnormality of the hypothalamus pituitary axis 0.3238455878311666 0.1146967342926522 0.9086855025031472 1.0 1.0 56 O76024,Q4J6C6,Q10713,P10644,O14654,Q99496,P51809,Q969G3,O75874,Q03164,P16435,Q9UHX1,P48735,Q12824,Q06787 15 +Follicular thyroid carcinoma 0.5045420136260372 0.1123108824854996 0.9105769134218455 1.0 1.0 2 Q9UNW1 1 +Albuminuria 0.5030280090840191 0.1106390117546051 0.9119026104737742 1.0 1.0 2 Q14697 1 +Recurrent staphylococcus aureus infections 0.5030280090840173 0.1106390117546028 0.911902610473776 1.0 1.0 2 O95394 1 +Recurrent staphylococcal infections 0.5030280090840173 0.1106390117546028 0.911902610473776 1.0 1.0 2 O95394 1 +Glomerular deposits 0.500757002270997 0.1081808686870793 0.913852220459774 1.0 1.0 2 P57740 1 +Simplified gyral pattern 0.3217133587006101 0.1073084710277021 0.914544264441098 1.0 1.0 25 Q5KU26 1 +Abnormal vagina morphology 0.3155310454068257 0.1068171020606307 0.9149340796187342 1.0 1.0 16 Q9UBM7,P51809 2 +Impaired smooth pursuit 0.323640927445039 0.1064827655961291 0.9151993287237086 1.0 1.0 13 P11177,O00754 2 +Kyphoscoliosis 0.3324110078659653 0.1064013828688869 0.9152638959367538 1.0 1.0 45 Q9Y487,Q9NWM8,Q9NR77,O75844,Q5KU26 5 +Functional abnormality of male internal genitalia 0.3182359494130252 0.1049209205958549 0.9164385583556008 1.0 1.0 23 O76024,P04062,Q13423,P51809,Q9Y4P3,P16435,Q8N5K1 7 +Duplication of phalanx of hallux 0.4958364875094523 0.1030568260571727 0.9179178703253844 1.0 1.0 2 Q2M1P5 1 +Delayed epiphyseal ossification 0.3655303030303123 0.1023493294287961 0.9184794016329212 1.0 1.0 4 Q2M1P5,Q96HY6,Q9UG56 3 +Aplasia hypoplasia of toe 0.3234947713435973 0.1017797686074416 0.9189314845567907 1.0 1.0 27 Q13510,P10644,Q03164,Q9UHX1,Q9UBM7 5 +Chronic leukemia 0.3643939393939405 0.1005080544412321 0.9199409886998235 1.0 1.0 4 Q01130,O75792,P55265 3 +Chronic lymphatic leukemia 0.3643939393939405 0.1005080544412321 0.9199409886998235 1.0 1.0 4 Q01130,O75792,P55265 3 +Vertebral clefting 0.3527721837701836 0.0995859414648639 0.9206730554228284 1.0 1.0 8 O75845 1 +Extra axial cerebrospinal fluid accumulation 0.4920514761544181 0.099300211210821 0.920899910725109 1.0 1.0 2 Q03252 1 +Basal ganglia calcification 0.35874337632347 0.0983219363272777 0.9216766599040898 1.0 1.0 5 O00429 1 +Focal cortical dysplasia 0.4909159727479099 0.0982041022746632 0.9217702250683196 1.0 1.0 2 Q8WUM0 1 +Colpocephaly 0.3669446550416894 0.0980123567020281 0.921922481383419 1.0 1.0 6 O60341,Q8IY37,O94979,Q9NVI1,P53701 5 +Redundant skin 0.3168691316930869 0.097109438555148 0.9226394854074398 1.0 1.0 23 O96000,Q9Y4P3,Q8NCH0,Q9Y487 4 +Lambdoidal craniosynostosis 0.3621901065263575 0.0969940042071864 0.9227311559491154 1.0 1.0 4 P16435 1 +Abnormality of iron homeostasis 0.3580711513574308 0.0968615896941569 0.9228363123106824 1.0 1.0 5 P28288,Q02241 2 +Lipid accumulation in hepatocytes 0.3172981996423237 0.096671255383891 0.9229874677685186 1.0 1.0 59 P38571,P23786,Q16836,O75787,Q8N511,Q15067,O43772,P22626,Q15904,Q5XKP0 10 +Inflammatory abnormality of the eye 0.3269684123876616 0.0961536439375353 0.9233985469342508 1.0 1.0 31 P01889,P02786,P04439,Q14739,P28070,Q9NZ08 6 +Abnormal urine metabolite level 0.3440913809973104 0.0955468698699173 0.9238804637446156 1.0 1.0 133 Q16836,P06280,P53985,P15586,Q9Y619,Q14108,O96000,P16278,O00462,P54802,Q5XKP0,P35670,O95470,P04062,Q9Y4P3,P04066,Q9NQW6,P23786,P10253,Q9H6K4,P08236,O00754 22 +Abnormal scrotal rugation 0.4859954579863696 0.0936162557246121 0.9254139961250558 1.0 1.0 2 Q9UNW1 1 +Wide anterior fontanel 0.310864723706674 0.0933459318838335 0.9256287429847024 1.0 1.0 20 Q9Y487,Q08J23,Q32P28,Q6NUK1,P20674,P16435,O75718 7 +Medial flaring of the eyebrow 0.4856169568508615 0.0932741228823495 0.925685789392222 1.0 1.0 2 Q9BW83 1 +Decreased fertility in females 0.3560705790201617 0.0925608284400975 0.9262524644762038 1.0 1.0 5 P51809 1 +Delayed ability to sit 0.3120137363749649 0.0889999023458686 0.9290819877298636 1.0 1.0 16 P10253,Q10713 2 +Abnormal electroretinogram 0.3248090156601265 0.0888241929730533 0.929221630470614 1.0 1.0 30 P50897,O14773 2 +Pulmonary edema 0.3873532752745145 0.0883979443711959 0.929560395055944 1.0 1.0 3 Q13724,Q14315 2 +Periventricular cysts 0.3628949966491593 0.0875113716760496 0.9302650468195864 1.0 1.0 6 O96028,P11177 2 +Abnormality of the chin 0.3091030138552508 0.0874951331662149 0.9302779537680808 1.0 1.0 63 Q2VPK5,P11233,P16278,P10644,O00429,Q96EK5,O75844,Q9UHX1,O00754,Q06787 10 +Depressed nasal ridge 0.3086143731788904 0.0864717533311249 0.9310914095230398 1.0 1.0 17 P16278 1 +Intestinal malrotation 0.3193855740772146 0.0853612533733183 0.9319741960203054 1.0 1.0 26 P21964,Q8NCH0,Q15392,Q14739,Q9BV10,Q9UBM7 6 +Stroke like episode 0.3798378576184257 0.081455240118862 0.935079919751842 1.0 1.0 3 O76024 1 +Leukopenia 0.3284789857967344 0.0800695917494557 0.9361819073434852 1.0 1.0 37 P04062,Q14108,Q15904,P38571 4 +Erythroderma 0.3494055543776476 0.0787237675316102 0.9372523403897496 1.0 1.0 5 P48449,P18074 2 +Polyhydramnios 0.3289610726902802 0.07756389181208 0.9381749659751736 1.0 1.0 43 P04062,P21964,Q14739,Q9BV10,O75844,Q70HW3,Q9UBM7 7 +Large beaked nose 0.358225928733884 0.0757499846811885 0.9396180081731608 1.0 1.0 6 O75792,P55265,Q12797,Q9Y3Z3,P18074 5 +Abnormal nephron morphology 0.3227181364774489 0.0744700867351087 0.9406363423842212 1.0 1.0 53 P23786,P01889,O75306,P06280,Q9NQW6,Q14108,O95470,Q9NZ08 8 +Caesarian section 0.3465909090909175 0.0742427877078964 0.9408172001063256 1.0 1.0 4 O60313,O14802,P33991 3 +Abnormality of renal excretion 0.3575142399438371 0.0739900921486701 0.941018268971525 1.0 1.0 6 O43772 1 +Decreased circulating antibody level 0.327013576153085 0.0734545333792378 0.9414444233947744 1.0 1.0 36 P02786,Q15904,O00754 3 +Gastroparesis 0.3567706257702191 0.0721605934970136 0.9424741052163712 1.0 1.0 6 P12235,O00592 2 +Genetic anticipation 0.4576078728236117 0.0719572086018779 0.9426359621180688 1.0 1.0 2 Q9UBB4 1 +Abnormal renal insterstitial morphology 0.3283881888682551 0.0708000235829095 0.9435569130570228 1.0 1.0 10 P23786 1 +Absent testis 0.4545798637395849 0.070093236412555 0.9441194500242036 1.0 1.0 2 Q9NVI1 1 +Testicular dysgenesis 0.45457986373958 0.070093236412552 0.944119450024206 1.0 1.0 2 Q14781 1 +Laryngeal stenosis 0.3653918970086997 0.0698742303967977 0.9442937641483083 1.0 1.0 3 Q96HY6,O75369 2 +Hypoplasia of teeth 0.3051893793392113 0.0689106106890399 0.9450607724904144 1.0 1.0 17 P51648,O75844 2 +Bifid uvula 0.3221913671255366 0.0666015820706972 0.9468988862340548 1.0 1.0 31 O43505,Q15392 2 +Adrenocorticotropic hormone deficiency 0.4477668433005207 0.0661843711652484 0.9472310394940416 1.0 1.0 2 O00170 1 +Hyperaldosteronism 0.4477668433005184 0.0661843711652473 0.9472310394940424 1.0 1.0 2 Q01968 1 +Facial diplegia 0.3414697897964172 0.0642228685185613 0.9487927685359616 1.0 1.0 8 P12235 1 +Impaired pain sensation 0.3012635023267144 0.063709509819072 0.949201532391856 1.0 1.0 18 O95831,O15270,O15269,Q9NR77,O95140 5 +Unusual infection 0.3709697787858298 0.0632429768248088 0.9495730226967504 1.0 1.0 166 Q13510,P07602,P15586,Q9NZ08,Q06787,P16278,P01889,O75787,O00462,P10644,Q14739,P54802,Q9UBM7,P04062,Q16637,Q9Y4P3,Q9NPL8,P04066,P53634,P28070,Q96A33,Q8TAA9,P10253,Q9Y487,P02786,Q13423,P08236,Q9BV10,Q15904,O00754 30 +Portal fibrosis 0.3378787878787926 0.0631205559941176 0.949670505620332 1.0 1.0 4 P28288,Q9H3U1,P55263 3 +Abnormal pulmonary valve morphology 0.3160831187400468 0.0626439025752797 0.9500500688485009 1.0 1.0 12 P21964,P10644 2 +Hypoplasia of the brainstem 0.3138894314751882 0.0621220020969987 0.9504656756957856 1.0 1.0 25 Q10713,P11177,Q96EK5,Q9Y320,O43505 5 +Bladder diverticulum 0.3400302771290526 0.0598997070010555 0.9522355132569388 1.0 1.0 8 Q9NWM8 1 +Neoplasm of the peripheral nervous system 0.3132027281096189 0.0592074596226062 0.952786868148348 1.0 1.0 13 Q969G3,P10644,Q12824,Q99496 4 +Adrenocorticotropin deficient adrenal insufficiency 0.4311127933383721 0.0581665769027606 0.9536159433962736 1.0 1.0 2 O00170 1 +Anterior pituitary dysgenesis 0.431112793338368 0.0581665769027587 0.9536159433962752 1.0 1.0 2 Q15233 1 +Abnormal chromosome morphology 0.4307342922028706 0.0580078479559644 0.9537423772902808 1.0 1.0 2 O95453 1 +Abnormality of corneal size 0.3246210989702465 0.0578659906645756 0.9538553732276124 1.0 1.0 36 O96028,P52732,Q15555,Q8NCH0,Q9NWM8,O75845,Q9H2M9,Q9Y4P3,Q96EK5,Q9Y5P6,P18074,O43505 12 +Calvarial skull defect 0.3459080180489674 0.0578178608613107 0.9538937110676432 1.0 1.0 7 O96028,Q14739 2 +Proximal muscle weakness 0.3206040110421072 0.0571543806222572 0.9544222177094316 1.0 1.0 53 Q13510,P12235,P10253,P50402,Q13126,Q16637,P22626,P35670,O95140,Q13501,Q99720,P07196,P35637,P51114 14 +Waddling gait 0.3036647711161346 0.0544685191925866 0.9565618893872154 1.0 1.0 20 Q13510,P50402,Q9Y5P6,P07196,P22626 5 +Narrow foot 0.4201362604087725 0.0539484056213981 0.9569762706817596 1.0 1.0 2 O60828 1 +Polymicrogyria 0.3015412427701965 0.053644994276799 0.9572180078511004 1.0 1.0 65 P23786,Q96N66,Q9Y487,Q15392,Q96EK5,Q16625,O43505 7 +Neoplasm of the endocrine system 0.3199495735139357 0.052930269633656 0.9577874665134029 1.0 1.0 31 P48735,P42892 2 +Ectopia pupillae 0.3348130062008723 0.0521286853841648 0.9584261564018302 1.0 1.0 3 O96028 1 +Rieger anomaly 0.3348130062008723 0.0521286853841648 0.9584261564018302 1.0 1.0 3 O96028 1 +Hypoplasia of the iris 0.3348130062008723 0.0521286853841648 0.9584261564018302 1.0 1.0 3 O96028 1 +Craniofacial asymmetry 0.3348130062008723 0.0521286853841648 0.9584261564018302 1.0 1.0 3 O96028 1 +Abnormality of the spinal cord 0.3071750415720261 0.0511584270662984 0.9591992788348748 1.0 1.0 62 O96028,Q8TAA9,Q10713,P16278,P21964,O75845,P05067,Q9Y4P3,Q9Y5P6,P48506,P07196,Q9UHX1,O95140,O00754,Q12824 15 +Abnormality of the crus of the helix 0.4110522331566891 0.0510176348256633 0.9593114682877928 1.0 1.0 2 P08754 1 +Abnormality of cartilage of external ear 0.4110522331566891 0.0510176348256633 0.9593114682877928 1.0 1.0 2 P08754 1 +Abnormal number of granulocyte precursors 0.3313138962514229 0.0506075489573866 0.9596382473373896 1.0 1.0 3 O75533,Q01130 2 +Cough 0.3065241561887729 0.0492637406297772 0.9607091152002808 1.0 1.0 22 P04062,P01889,P10644,O15269,Q9NR77 5 +Truncus arteriosus 0.336201619513749 0.0486054352272983 0.961233738401813 1.0 1.0 8 Q9UHX1 1 +Abnormality of the sense of smell 0.3011197424240913 0.0484460971047237 0.9613607222339924 1.0 1.0 17 P04062,Q969G3,O00592,O95140,Q12824 5 +Emg axonal abnormality 0.3974261922785706 0.0474508948285864 0.9621538664656656 1.0 1.0 2 Q92734 1 +Sparse hair 0.3047836369915066 0.0461988250670133 0.963151778937246 1.0 1.0 63 Q9Y487,P51809,O75844,P53634,Q14574,Q06787 6 +Heat intolerance 0.3175712067801068 0.0454890111320901 0.9637175336792024 1.0 1.0 3 P61978 1 +Congenital ptosis 0.3875851627554814 0.0454100574078388 0.9637804646062524 1.0 1.0 2 P51530 1 +Prominent antihelix 0.3875851627554783 0.0454100574078382 0.9637804646062528 1.0 1.0 2 P98175 1 +Abnormal left atrium morphology 0.38720666161998 0.0453395441890586 0.9638366681271042 1.0 1.0 2 Q14315 1 +Orthopnea 0.38720666161998 0.0453395441890586 0.9638366681271042 1.0 1.0 2 Q14315 1 +Abnormal right atrium morphology 0.38720666161998 0.0453395441890586 0.9638366681271042 1.0 1.0 2 Q14315 1 +Interstitial cardiac fibrosis 0.38720666161998 0.0453395441890586 0.9638366681271042 1.0 1.0 2 Q14315 1 +Restrictive cardiomyopathy 0.3872066616199802 0.0453395441890586 0.9638366681271042 1.0 1.0 2 Q969N2 1 +Left atrial enlargement 0.38720666161998 0.0453395441890586 0.9638366681271042 1.0 1.0 2 Q14315 1 +Peripheral edema 0.38720666161998 0.0453395441890586 0.9638366681271042 1.0 1.0 2 Q14315 1 +Pulmonary venous hypertension 0.38720666161998 0.0453395441890586 0.9638366681271042 1.0 1.0 2 Q14315 1 +Progressive distal muscle weakness 0.3165467625899295 0.045158254427516 0.96398116842343 1.0 1.0 3 P55084,P40939 2 +Synostosis involving bones of the hand 0.3211845102505698 0.0442357874989974 0.9647164556634048 1.0 1.0 10 O75367,Q6DKJ4,Q9Y5S9,P48651,O75369,Q15233,Q9H1A4,P16435,O60828 9 +Limitation of knee mobility 0.3204545454545536 0.0441199966033363 0.9648087533192944 1.0 1.0 4 Q9BPU6,P55072,Q14315 3 +Distal sensory impairment 0.3202147261860542 0.0431830180512306 0.965555642092314 1.0 1.0 33 O95831,O15270,O15269,Q9NR77,P54802,P07196,O95140 7 +Myeloproliferative disorder 0.3713096139288366 0.0428446300562687 0.9658253869927782 1.0 1.0 2 Q01130 1 +Impaired collagen induced platelet aggregation 0.3713096139288345 0.0428446300562684 0.9658253869927784 1.0 1.0 2 Q8N5K1 1 +Reduced forced vital capacity 0.3078379401741791 0.0426039258223231 0.9660172659798693 1.0 1.0 3 O95453,P06753 2 +Abnormal circulating ferritin concentration 0.318513010733514 0.04225914878967 0.9662921107182904 1.0 1.0 4 P36551 1 +Hypoplastic heart 0.3663890991672901 0.042236905185696 0.9663098427145314 1.0 1.0 2 O60826 1 +Metopic synostosis 0.3059447179098831 0.0421064663668673 0.9664138253290112 1.0 1.0 3 P61978,Q16531 2 +Abnormality of macular pigmentation 0.3032942067398749 0.0414426094374268 0.9669430445389626 1.0 1.0 3 Q9UM00,P55265 2 +Long penis 0.3576835730507137 0.0413218024086918 0.9670393521039292 1.0 1.0 2 O00170 1 +Abnormality of the pituitary gland 0.3174579337989276 0.0398742703042819 0.9681933641070462 1.0 1.0 54 O76024,Q4J6C6,P10644,O14654,Q99496,P51809,Q969G3,O75874,Q03164,P16435,Q9UHX1,P48735,Q12824,Q06787 14 +Distal joint laxity 0.3308099924299711 0.0394997808940522 0.968491928203117 1.0 1.0 2 O75340 1 +2 3 toe syndactyly 0.3098349187734676 0.0393260677201174 0.9686304236527156 1.0 1.0 25 Q9UHX1,Q9UBM7,P11233 3 +Tricuspid valve prolapse 0.3202119606358752 0.0390825309229196 0.9688245886317964 1.0 1.0 2 P53701 1 +Delirium 0.3194549583648677 0.0390575199321183 0.96884452929002 1.0 1.0 2 Q9UJS0 1 +Eversion of lateral third of lower eyelids 0.3084784254352694 0.0387544398622321 0.9690861692461086 1.0 1.0 2 P61978 1 +Delayed eruption of primary teeth 0.2857683573050644 0.0383908315421974 0.9693760709641306 1.0 1.0 2 Q13045 1 +Peptic ulcer 0.3100982372423307 0.0375266452642055 0.9700650952569432 1.0 1.0 12 Q9Y4P3,O76024,P04062,Q8N5K1 4 +Poikiloderma 0.2786823173040561 0.0368477249386035 0.970606420866932 1.0 1.0 3 P18074,Q9H1A4 2 +Overlapping toe 0.2982195784113591 0.0368112411350286 0.9706355109947484 1.0 1.0 19 Q9UHX1,Q9UBM7 2 +Abnormal thalamic mri signal intensity 0.3258369080537761 0.0358850335567211 0.9713740296733526 1.0 1.0 5 Q969G3,Q12824 2 +Aplasia hypoplasia of the optic nerve 0.2975462269612171 0.0333538336694262 0.9733924245543866 1.0 1.0 19 P37268,Q9Y5P6,P07196,Q9UHX1,P61978 5 +Sagittal craniosynostosis 0.3060606060606131 0.0314730347534635 0.974892296637628 1.0 1.0 4 P61978,P21281,Q9ULC3 3 +Polyuria 0.3060606060606129 0.0314730347534632 0.9748922966376284 1.0 1.0 4 P05023,Q9UNF1,Q9NP81 3 +Abnormal shape of the palpebral fissure 0.3298504854465193 0.0305344135298489 0.975640848141037 1.0 1.0 8 Q9UHX1,P55795 2 +Cns hypomyelination 0.3181480178953185 0.0304632716541541 0.975697584751518 1.0 1.0 33 Q99720,P07686 2 +Aplasia hypoplasia of the skin 0.3193984311595118 0.0275019275675744 0.978059402453545 1.0 1.0 50 Q13126,Q8NCH0,Q9NWM8,Q15392,O75844,P53634,Q9Y619,Q06787 8 +Subcapsular cataract 0.3361943745600081 0.0253902274706877 0.979743705945326 1.0 1.0 6 Q9H6K4 1 +Abnormal serum iron concentration 0.2976018015553793 0.0252212148195958 0.9798785153585472 1.0 1.0 4 Q02241 1 +Increased head circumference 0.2993760150422715 0.0242953944188222 0.9806169867695902 1.0 1.0 95 Q06787,P08236,P07602,Q15392,P07686,O75844,O00754,O43505 8 +Abnormal retinal morphology 0.3773923194596693 0.0238782860893728 0.9809496945349196 1.0 1.0 178 Q13510,O75503,Q16836,P50897,P07602,Q9Y619,Q9NZ08,P06865,Q10713,P16278,P01889,P21964,P04439,Q5XKP0,Q9UHX1,O14773,P04062,P10619,Q9Y4P3,Q9H2C2,Q6P4Q7,P51648,P17900,O43505,Q9Y487,Q15555,Q96CU9,O75306,Q8NCH0,Q15067,P07686,Q9BV10,O00754 33 +Congenital malformation of the great arteries 0.2883993146531356 0.0223715005679712 0.9821516139126294 1.0 1.0 85 Q2VPK5,P01889,Q9NWM8,Q15392,O75844,P42892,Q9UBM7 7 +Abnormal urine alpha ketoglutarate concentration 0.3156498673740072 0.0202869055842116 0.9838145014688592 1.0 1.0 5 P09622,P21281,P00367,P21912 4 +Elevated urinary carboxylic acid 0.3337212424350364 0.0202766281215982 0.9838227000111937 1.0 1.0 6 O96000 1 +Diastema 0.2876726646523627 0.01890456787462 0.984917235556021 1.0 1.0 4 Q99496 1 +Sparse eyebrow 0.3075186780676803 0.0178051068258946 0.98579433074868 1.0 1.0 26 Q96EK5,O75844,Q14574 3 +Malignant neoplasm of the central nervous system 0.2947731173826838 0.0174478650033112 0.9860793242057012 1.0 1.0 17 P48735 1 +Missing ribs 0.3178642183472576 0.0153575167511606 0.9877469561473844 1.0 1.0 9 Q14739 1 +Hypoventilation 0.3125470927861762 0.0140074395250606 0.9888240457370494 1.0 1.0 10 O75306,O43819 2 +Contractures involving the joints of the feet 0.2936450765372639 0.0135822185438564 0.9891632907100878 1.0 1.0 19 Q8IZA0 1 +Sarcoma 0.3149310952883309 0.0112605274676744 0.9910155888572224 1.0 1.0 53 Q13126,Q15392,Q13501,O75874,Q01844,Q92804,P48735 7 +Abnormality of skeletal muscle fiber size 0.2954291518904594 0.0093227176603404 0.992561655262469 1.0 1.0 16 Q13501,P22626 2 +Lumbar hyperlordosis 0.3014479434720151 0.0092852552905024 0.9925915446152708 1.0 1.0 13 Q9H2M9,O95140,Q9Y5P6,P04066 4 +Underdeveloped nasal alae 0.2969888962678865 0.0091702512373878 0.9926833006669672 1.0 1.0 21 Q08J23,Q8TC12,Q5KU26,P55795 4 +Broad columella 0.2655303030303063 0.0083084025381452 0.9933709301569208 1.0 1.0 4 Q13868,Q8TC12,P36543 3 +Abnormality of the humeroradial joint 0.3245848094389016 0.0055758198860773 0.995551162451314 1.0 1.0 7 P10644,P16435 2 +Abnormality of fontanelles 0.3186574175970861 0.0050247158674305 0.9959908736572128 1.0 1.0 43 Q9Y487,Q32P28,O75844,Q9Y619,O75718 5 +Abnormal sclera morphology 0.3035402353485097 0.0048433687459841 0.9961355659641012 1.0 1.0 25 Q96EK5,Q8NCH0,O75718 3 +Acute phase response 0.2979899644179578 0.0041218618295556 0.9967112393969716 1.0 1.0 22 P28070,P14174,P10644,P01889 4 +Abnormal urine carboxylic acid level 0.2919159003099913 0.0038741271988765 0.9969089014537436 1.0 1.0 17 O96000,Q9H6K4,P36551,Q5XKP0,Q9Y619,Q3ZCQ8 6 +Pancytopenia 0.309241926443696 0.0035583364481366 0.9971608642772992 1.0 1.0 29 P04062,Q14108,O00754 3 +Coloboma 0.3168794997199035 0.0013171349057065 0.9989490786981065 1.0 1.0 38 O96028,Q9NRG9,Q10713,P53701,O95202,Q9H2M9,Q96EK5,Q9Y5P6,Q9UHX1,P61978,O75340,Q9UBM7,O43505,O60828 14 +Oligohydramnios 0.3011124812464387 0.001046234065944 0.9991652261440886 1.0 1.0 24 P23786,Q9Y5P4,Q07021,Q9UHX1,P51114 5 +Medulloblastoma 0.2386363636363665 0.0005706430061625 0.9995446927803632 1.0 1.0 4 P04637,Q12824,P35222 3 diff --git a/msigdb_hp/selections.json b/msigdb_hp/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..d351e3f4fbfd58586f5c3288fb254287303598d2 --- /dev/null +++ b/msigdb_hp/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["11 pairs of ribs", "2 3 finger syndactyly", "2 3 toe cutaneous syndactyly", "2 3 toe syndactyly", "3 4 finger syndactyly", "3 methylglutaconic aciduria", "4 5 toe syndactyly", "Abdominal aortic aneurysm", "Abdominal distention", "Abdominal obesity", "Abdominal pain", "Abdominal wall muscle weakness", "Abducens palsy", "Abnormal 2nd finger morphology", "Abnormal 3rd finger morphology", "Abnormal 5th finger morphology", "Abnormal 5th finger phalanx morphology", "Abnormal abdomen morphology", "Abnormal acetabulum morphology", "Abnormal activity of mitochondrial respiratory chain", "Abnormal adipose tissue morphology", "Abnormal aggressive impulsive or violent behavior", "Abnormal aldolase level", "Abnormal anatomic location of the heart", "Abnormal anterior chamber morphology", "Abnormal anterior eye segment morphology", "Abnormal anterior horn cell morphology", "Abnormal aortic arch morphology", "Abnormal aortic morphology", "Abnormal aortic valve cusp morphology", "Abnormal aortic valve morphology", "Abnormal aortic valve physiology", "Abnormal arachnoid mater morphology", "Abnormal arm span", "Abnormal arterial physiology", "Abnormal astrocyte morphology", "Abnormal atrial arrangement", "Abnormal atrioventricular conduction", "Abnormal atrioventricular valve morphology", "Abnormal atrioventricular valve physiology", "Abnormal auditory evoked potentials", "Abnormal autonomic nervous system physiology", "Abnormal b cell morphology", "Abnormal b cell subset distribution", "Abnormal basal ganglia mri signal intensity", "Abnormal basophil count", "Abnormal basophil morphology", "Abnormal biliary tract morphology", "Abnormal bleeding", "Abnormal blistering of the skin", "Abnormal blood carbon dioxide level", "Abnormal blood chloride concentration", "Abnormal blood gas level", "Abnormal blood glucose concentration", "Abnormal blood inorganic cation concentration", "Abnormal blood ion concentration", "Abnormal blood monovalent inorganic cation concentration", "Abnormal blood phosphate concentration", "Abnormal blood potassium concentration", "Abnormal blood sodium concentration", "Abnormal blood transition element cation concentration", "Abnormal blood zinc concentration", "Abnormal bone structure", "Abnormal brain choline level by mrs", "Abnormal brain lactate level by mrs", "Abnormal brain n acetyl aspartate level by mrs", "Abnormal brain positron emission tomography", "Abnormal brainstem morphology", "Abnormal brainstem mri signal intensity", "Abnormal breath sound", "Abnormal bronchoalveolar lavage fluid morphology", "Abnormal bronchus morphology", "Abnormal bronchus physiology", "Abnormal c peptide level", "Abnormal c reactive protein level", "Abnormal calcium phosphate regulating hormone level", "Abnormal cardiac atrium morphology", "Abnormal cardiac exercise stress test", "Abnormal cardiac septum morphology", "Abnormal cardiac test", "Abnormal cardiac ventricle morphology", "Abnormal cardiac ventricular function", "Abnormal cardiomyocyte morphology", "Abnormal carotid artery morphology", "Abnormal cartilage morphology", "Abnormal caudate nucleus morphology", "Abnormal cd4 cd8 ratio", "Abnormal cell morphology", "Abnormal cell proliferation", "Abnormal cellular composition of bronchoalveolar fluid", "Abnormal cellular phenotype", "Abnormal central sensory function", "Abnormal cerebellar vermis morphology", "Abnormal cerebral artery morphology", "Abnormal cerebral cortex morphology", "Abnormal cerebral vascular morphology", "Abnormal cerebral vein morphology", "Abnormal cerebral ventricle morphology", "Abnormal cerebrospinal fluid metabolite concentration", "Abnormal cervical curvature", "Abnormal cervical spine morphology", "Abnormal chorioretinal morphology", "Abnormal choroid morphology", "Abnormal choroid plexus morphology", "Abnormal chromosome morphology", "Abnormal ciliary body morphology", "Abnormal circulating acetylcarnitine concentration", "Abnormal circulating albumin concentration", "Abnormal circulating amino acid concentration", "Abnormal circulating amylase level", "Abnormal circulating androgen level", "Abnormal circulating apolipoprotein concentration", "Abnormal circulating arginine concentration", "Abnormal circulating aromatic amino acid concentration", "Abnormal circulating aspartate family amino acid concentration", "Abnormal circulating bilirubin concentration", "Abnormal circulating branched chain amino acid concentration", "Abnormal circulating carbohydrate concentration", "Abnormal circulating carboxylic acid concentration", "Abnormal circulating ceruloplasmin concentration", "Abnormal circulating cholesterol concentration", "Abnormal circulating citrulline concentration", "Abnormal circulating copper concentration", "Abnormal circulating creatinine concentration", "Abnormal circulating dehydroepiandrosterone concentration", "Abnormal circulating dicarboxylic acid concentration", "Abnormal circulating estrogen level", "Abnormal circulating fatty acid anion concentration", "Abnormal circulating fatty acid concentration", "Abnormal circulating ferritin concentration", "Abnormal circulating follicle stimulating hormone concentration", "Abnormal circulating free fatty acid concentration", "Abnormal circulating gaba concentration", "Abnormal circulating glutamine concentration", "Abnormal circulating glutamine family amino acid concentration", "Abnormal circulating glycine concentration", "Abnormal circulating gonadotropin concentration", "Abnormal circulating hormone concentration", "Abnormal circulating iga level", "Abnormal circulating ige level", "Abnormal circulating igg level", "Abnormal circulating igm level", "Abnormal circulating inhibin level", "Abnormal circulating lipid concentration", "Abnormal circulating long chain fatty acid concentration", "Abnormal circulating metabolite concentration", "Abnormal circulating methionine concentration", "Abnormal circulating monocarboxylic acid cocentration", "Abnormal circulating nitrogen compound concentration", "Abnormal circulating non proteinogenic amino acid concentration", "Abnormal circulating nucleobase concentration", "Abnormal circulating phenylalanine concentration", "Abnormal circulating porphyrin concentration", "Abnormal circulating progesterone level", "Abnormal circulating proline concentration", "Abnormal circulating protein concentration", "Abnormal circulating proteinogenic amino acid concentration", "Abnormal circulating proteinogenic amino acid derivative concentration", "Abnormal circulating pyruvate family amino acid concentration", "Abnormal circulating renin", "Abnormal circulating serine concentration", "Abnormal circulating serine family amino acid concentration", "Abnormal circulating sex hormone concentration", "Abnormal circulating sulfur amino acid concentration", "Abnormal circulating tyrosine concentration", "Abnormal clavicle morphology", "Abnormal cns myelination", "Abnormal coccyx morphology", "Abnormal cochlea morphology", "Abnormal conjugate eye movement", "Abnormal conjunctiva morphology", "Abnormal connection of the cardiac segments", "Abnormal consumption behavior", "Abnormal conus terminalis morphology", "Abnormal cornea morphology", "Abnormal corneal epithelium morphology", "Abnormal coronary artery morphology", "Abnormal corpus callosum morphology", "Abnormal corpus striatum morphology", "Abnormal cortical bone morphology", "Abnormal cortical gyration", "Abnormal cranial nerve morphology", "Abnormal cranial nerve physiology", "Abnormal cry", "Abnormal csf carboxylic acid concentration", "Abnormal csf metabolite level", "Abnormal csf protein level", "Abnormal csf pyruvate family amino acid concentration", "Abnormal cutaneous elastic fiber morphology", "Abnormal delayed hypersensitivity skin test", "Abnormal delivery", "Abnormal dense granules", "Abnormal dental pulp morphology", "Abnormal dental root morphology", "Abnormal dentate nucleus morphology", "Abnormal dentin morphology", "Abnormal dermatoglyphics", "Abnormal dermoepidermal junction morphology", "Abnormal diaphysis morphology", "Abnormal distal phalanx morphology of finger", "Abnormal dlco", "Abnormal drinking behavior", "Abnormal duodenum morphology", "Abnormal dura mater morphology", "Abnormal eating behavior", "Abnormal echocardiogram", "Abnormal elasticity of skin", "Abnormal electrophysiology of sinoatrial node origin", "Abnormal electroretinogram", "Abnormal emotion affect behavior", "Abnormal enchondral ossification", "Abnormal endocardium morphology", "Abnormal endocrine physiology", "Abnormal enzyme coenzyme activity", "Abnormal eosinophil morphology", "Abnormal epidermal morphology", "Abnormal epiglottis morphology", "Abnormal epiphyseal ossification", "Abnormal epiphysis morphology of the phalanges of the hand", "Abnormal erythrocyte enzyme level", "Abnormal erythrocyte morphology", "Abnormal erythrocyte physiology", "Abnormal erythrocyte sedimentation rate", "Abnormal esophagus morphology", "Abnormal esophagus physiology", "Abnormal external genitalia", "Abnormal exteroceptive sensation", "Abnormal eyebrow morphology", "Abnormal eyelash morphology", "Abnormal eyelid morphology", "Abnormal eyelid physiology", "Abnormal facial expression", "Abnormal facial shape", "Abnormal factor ix activity", "Abnormal fallopian tube morphology", "Abnormal fear anxiety related behavior", "Abnormal female reproductive system physiology", "Abnormal femoral head morphology", "Abnormal femoral neck head morphology", "Abnormal femoral neck morphology", "Abnormal finger phalanx morphology", "Abnormal fingernail morphology", "Abnormal fingertip morphology", "Abnormal foot bone ossification", "Abnormal foramen magnum morphology", "Abnormal forearm bone morphology", "Abnormal form of the vertebral bodies", "Abnormal foveal morphology", "Abnormal full field electroretinogram", "Abnormal fundus autofluorescence imaging", "Abnormal gallbladder morphology", "Abnormal gastrointestinal motility", "Abnormal glial cell morphology", "Abnormal globus pallidus morphology", "Abnormal glomerular basement membrane morphology", "Abnormal glomerular filtration rate", "Abnormal glomerular mesangial cellularity", "Abnormal glomerular mesangium morphology", "Abnormal glucose homeostasis", "Abnormal glycosylation", "Abnormal granulocyte count", "Abnormal granulocytopoietic cell morphology", "Abnormal greater sciatic notch morphology", "Abnormal growth hormone level", "Abnormal hair laboratory examination", "Abnormal hair morphology", "Abnormal hair pattern", "Abnormal hair quantity", "Abnormal hair whorl", "Abnormal hand bone ossification", "Abnormal hand morphology", "Abnormal hdl cholesterol concentration", "Abnormal head movements", "Abnormal heart rate variability", "Abnormal heart sound", "Abnormal heart valve morphology", "Abnormal heart valve physiology", "Abnormal hemoglobin", "Abnormal hemoglobin concentration", "Abnormal hepatic iron concentration", "Abnormal humerus morphology", "Abnormal hypothalamus morphology", "Abnormal hypothalamus physiology", "Abnormal ileum morphology", "Abnormal iliac wing morphology", "Abnormal ilium morphology", "Abnormal immune system morphology", "Abnormal incisor morphology", "Abnormal inflammatory response", "Abnormal insulin level", "Abnormal internal genitalia", "Abnormal intestine morphology", "Abnormal intraocular pressure", "Abnormal involuntary eye movements", "Abnormal iris pigmentation", "Abnormal jaw morphology", "Abnormal jejunum morphology", "Abnormal joint morphology", "Abnormal labia majora morphology", "Abnormal labia minora morphology", "Abnormal labia morphology", "Abnormal lacrimal duct morphology", "Abnormal lacrimal gland morphology", "Abnormal lactate dehydrogenase level", "Abnormal large intestine morphology", "Abnormal large intestine physiology", "Abnormal larynx morphology", "Abnormal larynx physiology", "Abnormal lateral ventricle morphology", "Abnormal ldl cholesterol concentration", "Abnormal left atrium morphology", "Abnormal left ventricle morphology", "Abnormal left ventricular outflow tract morphology", "Abnormal length of corpus callosum", "Abnormal leukocyte count", "Abnormal leukocyte physiology", "Abnormal levels of alpha fetoprotein", "Abnormal libido", "Abnormal light and dark adapted electroretinogram", "Abnormal lip morphology", "Abnormal liver morphology", "Abnormal liver parenchyma morphology", "Abnormal liver physiology", "Abnormal localization of kidney", "Abnormal location of ears", "Abnormal lower limb bone morphology", "Abnormal lower motor neuron morphology", "Abnormal lumbar spine morphology", "Abnormal lung development", "Abnormal lung lobation", "Abnormal lymphatic vessel morphology", "Abnormal lymphocyte morphology", "Abnormal macrophage morphology", "Abnormal macroscopic urine appearance", "Abnormal macular morphology", "Abnormal magnesium concentration", "Abnormal male reproductive system physiology", "Abnormal mandibular ramus morphology", "Abnormal mast cell morphology", "Abnormal mean corpuscular hemoglobin concentration", "Abnormal mean corpuscular volume", "Abnormal megakaryocyte morphology", "Abnormal meningeal morphology", "Abnormal metabolic brain imaging by mrs", "Abnormal metabolism", "Abnormal metacarpal morphology", "Abnormal metaphyseal trabeculation", "Abnormal metatarsal morphology", "Abnormal midbrain morphology", "Abnormal middle phalanx morphology of the hand", "Abnormal mitochondria in muscle tissue", "Abnormal mitochondrial morphology", "Abnormal mitochondrial number", "Abnormal mitochondrial shape", "Abnormal mitral valve physiology", "Abnormal monocyte morphology", "Abnormal morphology of myocardial trabeculae", "Abnormal morphology of the abdominal musculature", "Abnormal morphology of the choroidal vasculature", "Abnormal morphology of the conjunctival vasculature", "Abnormal morphology of the great vessels", "Abnormal morphology of the limbic system", "Abnormal morphology of the musculature of the neck", "Abnormal morphology of the olfactory bulb", "Abnormal morphology of the radius", "Abnormal motor evoked potentials", "Abnormal motor nerve conduction velocity", "Abnormal muscle fiber alpha dystroglycan", "Abnormal muscle fiber morphology", "Abnormal muscle fiber protein expression", "Abnormal muscle fiber type distribution", "Abnormal muscle glycogen content", "Abnormal myelination", "Abnormal myeloid cell morphology", "Abnormal myeloid leukocyte morphology", "Abnormal myocardium morphology", "Abnormal nasal base", "Abnormal nasal bridge morphology", "Abnormal nasal mucosa morphology", "Abnormal nasolacrimal system morphology", "Abnormal natural killer cell morphology", "Abnormal natural killer cell physiology", "Abnormal nephron morphology", "Abnormal nerve conduction velocity", "Abnormal nervous system electrophysiology", "Abnormal neural tube morphology", "Abnormal neuron morphology", "Abnormal neutrophil count", "Abnormal nipple morphology", "Abnormal number of erythroid precursors", "Abnormal number of granulocyte precursors", "Abnormal number of incisors", "Abnormal number of permanent teeth", "Abnormal number of teeth", "Abnormal odontoid tissue morphology", "Abnormal optical coherence tomography", "Abnormal oral frenulum morphology", "Abnormal oral mucosa morphology", "Abnormal oral physiology", "Abnormal ossification involving the femoral head and neck", "Abnormal ovarian morphology", "Abnormal ovarian physiology", "Abnormal palate morphology", "Abnormal palmar dermatoglyphics", "Abnormal pancreas morphology", "Abnormal pancreas size", "Abnormal paranasal sinus morphology", "Abnormal parietal bone morphology", "Abnormal parotid gland morphology", "Abnormal patella morphology", "Abnormal pattern of respiration", "Abnormal pelvis bone morphology", "Abnormal pelvis bone ossification", "Abnormal penis morphology", "Abnormal pericardium morphology", "Abnormal peripheral action potential amplitude", "Abnormal peripheral myelination", "Abnormal peripheral nervous system morphology", "Abnormal peripheral nervous system physiology", "Abnormal peristalsis", "Abnormal periventricular white matter morphology", "Abnormal phalangeal joint morphology of the hand", "Abnormal pharynx morphology", "Abnormal pigmentation of the oral mucosa", "Abnormal pineal morphology", "Abnormal placenta morphology", "Abnormal placental membrane morphology", "Abnormal placental size", "Abnormal platelet aggregation", "Abnormal platelet function", "Abnormal platelet granules", "Abnormal platelet morphology", "Abnormal platelet volume", "Abnormal pleura morphology", "Abnormal pons morphology", "Abnormal posterior segment imaging", "Abnormal posturing", "Abnormal pr interval", "Abnormal preputium morphology", "Abnormal prolactin level", "Abnormal proportion of cd4 positive t cells", "Abnormal proportion of cd8 positive t cells", "Abnormal proportion of class switched memory b cells", "Abnormal proportion of double negative alpha beta regulatory t cell", "Abnormal prostate morphology", "Abnormal protein glycosylation", "Abnormal protein o linked glycosylation", "Abnormal proximal phalanx morphology of the hand", "Abnormal pulmonary interstitial morphology", "Abnormal pulmonary thoracic imaging finding", "Abnormal pulmonary valve morphology", "Abnormal pulmonary valve physiology", "Abnormal pupil morphology", "Abnormal pupillary function", "Abnormal pupillary light reflex", "Abnormal pyramidal sign", "Abnormal qrs complex", "Abnormal qt interval", "Abnormal rectum morphology", "Abnormal reflex", "Abnormal renal collecting system morphology", "Abnormal renal cortex morphology", "Abnormal renal corticomedullary differentiation", "Abnormal renal echogenicity", "Abnormal renal insterstitial morphology", "Abnormal renal medulla morphology", "Abnormal renal morphology", "Abnormal renal pelvis morphology", "Abnormal renal physiology", "Abnormal renal resorption", "Abnormal renal tubule morphology", "Abnormal renal vascular morphology", "Abnormal respiratory motile cilium morphology", "Abnormal respiratory motile cilium physiology", "Abnormal respiratory system morphology", "Abnormal response to acth stimulation test", "Abnormal response to endocrine stimulation test", "Abnormal response to insulin tolerance test", "Abnormal reticulocyte morphology", "Abnormal retinal artery morphology", "Abnormal retinal morphology", "Abnormal retinal vascular morphology", "Abnormal rib cage morphology", "Abnormal rib ossification", "Abnormal right atrium morphology", "Abnormal right ventricle morphology", "Abnormal saccadic eye movements", "Abnormal sacroiliac joint morphology", "Abnormal sacrum morphology", "Abnormal salivary gland morphology", "Abnormal sarcomere morphology", "Abnormal scalp morphology", "Abnormal scapula morphology", "Abnormal sclera morphology", "Abnormal scrotal rugation", "Abnormal sella turcica morphology", "Abnormal sensory nerve conduction velocity", "Abnormal serum insulin like growth factor 1 level", "Abnormal serum interferon level", "Abnormal serum interleukin level", "Abnormal serum iron concentration", "Abnormal sex determination", "Abnormal shape of the frontal region", "Abnormal shape of the occiput", "Abnormal shape of the palpebral fissure", "Abnormal sharpey fiber morphology", "Abnormal shoulder morphology", "Abnormal shoulder physiology", "Abnormal size of pituitary gland", "Abnormal size of the clitoris", "Abnormal size of the palpebral fissures", "Abnormal skin morphology of the palm", "Abnormal social behavior", "Abnormal soft palate morphology", "Abnormal speech prosody", "Abnormal sperm motility", "Abnormal spermatogenesis", "Abnormal spinal meningeal morphology", "Abnormal sputum", "Abnormal st segment", "Abnormal sternal ossification", "Abnormal sternum morphology", "Abnormal stomach morphology", "Abnormal stool composition", "Abnormal subarachnoid space morphology", "Abnormal subclavian artery morphology", "Abnormal subcutaneous fat tissue distribution", "Abnormal substantia nigra morphology", "Abnormal superior cerebellar peduncle morphology", "Abnormal sweat gland morphology", "Abnormal sweat homeostasis", "Abnormal synaptic transmission at the neuromuscular junction", "Abnormal systemic arterial morphology", "Abnormal systemic blood pressure", "Abnormal t cell morphology", "Abnormal t cell proliferation", "Abnormal t cell subset distribution", "Abnormal t wave", "Abnormal talus morphology", "Abnormal temper tantrums", "Abnormal temporal bone morphology", "Abnormal tendon morphology", "Abnormal testis morphology", "Abnormal thalamic mri signal intensity", "Abnormal thalamic size", "Abnormal thoracic spine morphology", "Abnormal thorax morphology", "Abnormal thrombocyte morphology", "Abnormal thrombosis", "Abnormal thumb morphology", "Abnormal thyroid hormone level", "Abnormal thyroid morphology", "Abnormal thyroid stimulating hormone level", "Abnormal tissue metabolite concentration", "Abnormal toenail morphology", "Abnormal tongue morphology", "Abnormal tongue physiology", "Abnormal trabecular bone morphology", "Abnormal tracheal morphology", "Abnormal tracheobronchial morphology", "Abnormal transferrin saturation", "Abnormal tricuspid valve morphology", "Abnormal tricuspid valve physiology", "Abnormal umbilicus morphology", "Abnormal upper limb bone morphology", "Abnormal upper motor neuron morphology", "Abnormal ureter morphology", "Abnormal ureter physiology", "Abnormal urinary color", "Abnormal urinary electrolyte concentration", "Abnormal urine alpha ketoglutarate concentration", "Abnormal urine carbohydrate level", "Abnormal urine carboxylic acid level", "Abnormal urine cytology", "Abnormal urine hormone level", "Abnormal urine magnesium concentration", "Abnormal urine metabolite level", "Abnormal urine ph", "Abnormal urine phosphate concentration", "Abnormal urine potassium concentration", "Abnormal urine protein level", "Abnormal urine sodium concentration", "Abnormal uterus morphology", "Abnormal uvea morphology", "Abnormal uvula morphology", "Abnormal vagina morphology", "Abnormal vascular morphology", "Abnormal vascular physiology", "Abnormal vena cava morphology", "Abnormal venous morphology", "Abnormal ventricular septum morphology", "Abnormal vertebral morphology", "Abnormal vertebral segmentation and fusion", "Abnormal vestibulo ocular reflex", "Abnormal visual electrophysiology", "Abnormal visual field test", "Abnormal visual fixation", "Abnormal vitamin b12 level", "Abnormal vitreous humor morphology", "Abnormal waist to hip ratio", "Abnormal z disc morphology", "Abnormalities of placenta or umbilical cord", "Abnormality iris morphology", "Abnormality of abdominal situs", "Abnormality of acid base homeostasis", "Abnormality of adrenal morphology", "Abnormality of adrenal physiology", "Abnormality of alkaline phosphatase level", "Abnormality of amino acid metabolism", "Abnormality of bladder morphology", "Abnormality of blood circulation", "Abnormality of blood volume homeostasis", "Abnormality of body mass index", "Abnormality of bone marrow cell morphology", "Abnormality of bone mineral density", "Abnormality of canine", "Abnormality of cardiovascular system electrophysiology", "Abnormality of carpal bone ossification", "Abnormality of cartilage of external ear", "Abnormality of central nervous system electrophysiology", "Abnormality of chorioretinal pigmentation", "Abnormality of chromosome segregation", "Abnormality of chromosome stability", "Abnormality of circulating adrenocorticotropin level", "Abnormality of circulating enzyme level", "Abnormality of circulating fibrinogen", "Abnormality of circulating glucocorticoid level", "Abnormality of circulating leptin level", "Abnormality of coagulation", "Abnormality of complement system", "Abnormality of coordination", "Abnormality of corneal size", "Abnormality of corneal stroma", "Abnormality of corneal thickness", "Abnormality of cranial sutures", "Abnormality of dental color", "Abnormality of dental eruption", "Abnormality of dental morphology", "Abnormality of dental structure", "Abnormality of dermal melanosomes", "Abnormality of digestive system morphology", "Abnormality of dna repair", "Abnormality of earlobe", "Abnormality of endocrine pancreas physiology", "Abnormality of epiphysis morphology", "Abnormality of exocrine pancreas physiology", "Abnormality of extrapyramidal motor function", "Abnormality of facial adipose tissue", "Abnormality of facial musculature", "Abnormality of facial skeleton", "Abnormality of facial soft tissue", "Abnormality of female external genitalia", "Abnormality of femur morphology", "Abnormality of fibula morphology", "Abnormality of finger", "Abnormality of fluid regulation", "Abnormality of folate metabolism", "Abnormality of fontanelles", "Abnormality of foveal pigmentation", "Abnormality of frontal sinus", "Abnormality of frontalis muscle belly", "Abnormality of fundus pigmentation", "Abnormality of globe location", "Abnormality of globe size", "Abnormality of glycolipid metabolism", "Abnormality of hair growth", "Abnormality of hair pigmentation", "Abnormality of hair texture", "Abnormality of hand joint mobility", "Abnormality of head blood vessel", "Abnormality of hepatobiliary system physiology", "Abnormality of hindbrain morphology", "Abnormality of humoral immunity", "Abnormality of immune serum protein physiology", "Abnormality of iron homeostasis", "Abnormality of krebs cycle metabolism", "Abnormality of lens shape", "Abnormality of limb epiphysis morphology", "Abnormality of lipoprotein cholesterol concentration", "Abnormality of long bone morphology", "Abnormality of lower limb epiphysis morphology", "Abnormality of lower limb joint", "Abnormality of lower limb metaphyses", "Abnormality of lower lip", "Abnormality of lysosomal metabolism", "Abnormality of macular pigmentation", "Abnormality of malar bones", "Abnormality of male internal genitalia", "Abnormality of metacarpal epiphyses", "Abnormality of metacarpophalangeal joint", "Abnormality of mouth shape", "Abnormality of mouth size", "Abnormality of muscle size", "Abnormality of nail color", "Abnormality of neuronal migration", "Abnormality of neutrophil morphology", "Abnormality of neutrophil physiology", "Abnormality of neutrophils", "Abnormality of ocular smooth pursuit", "Abnormality of pain sensation", "Abnormality of pancreas physiology", "Abnormality of pelvic girdle bone morphology", "Abnormality of periauricular region", "Abnormality of peripheral nerves", "Abnormality of prenatal development or birth", "Abnormality of primary teeth", "Abnormality of prothrombin", "Abnormality of pulmonary circulation", "Abnormality of refraction", "Abnormality of renal excretion", "Abnormality of renin angiotensin system", "Abnormality of reproductive system physiology", "Abnormality of retinal pigmentation", "Abnormality of salivation", "Abnormality of secondary sexual hair", "Abnormality of skeletal maturation", "Abnormality of skeletal muscle fiber size", "Abnormality of skin adnexa physiology", "Abnormality of skin physiology", "Abnormality of skin pigmentation", "Abnormality of skull ossification", "Abnormality of small intestinal villus morphology", "Abnormality of somatosensory evoked potentials", "Abnormality of subcutaneous fat tissue", "Abnormality of t cell physiology", "Abnormality of taste sensation", "Abnormality of temperature regulation", "Abnormality of thalamus morphology", "Abnormality of the 1st metacarpal", "Abnormality of the 2nd toe", "Abnormality of the 3rd toe", "Abnormality of the 4th metacarpal", "Abnormality of the 5th metacarpal", "Abnormality of the 5th toe", "Abnormality of the abdominal organs", "Abnormality of the abdominal wall", "Abnormality of the achilles tendon", "Abnormality of the adrenal glands", "Abnormality of the alveolar ridges", "Abnormality of the amniotic fluid", "Abnormality of the ankles", "Abnormality of the anterior fontanelle", "Abnormality of the antihelix", "Abnormality of the antitragus", "Abnormality of the anus", "Abnormality of the auditory canal", "Abnormality of the autonomic nervous system", "Abnormality of the axillary hair", "Abnormality of the basal ganglia", "Abnormality of the biliary system", "Abnormality of the bladder", "Abnormality of the brainstem white matter", "Abnormality of the breast", "Abnormality of the calcaneus", "Abnormality of the calf", "Abnormality of the calf musculature", "Abnormality of the calvaria", "Abnormality of the carpal bones", "Abnormality of the cerebral subcortex", "Abnormality of the cerebrospinal fluid", "Abnormality of the cervical spine", "Abnormality of the cheek", "Abnormality of the chin", "Abnormality of the choanae", "Abnormality of the clitoris", "Abnormality of the coagulation cascade", "Abnormality of the columella", "Abnormality of the common coagulation pathway", "Abnormality of the costochondral junction", "Abnormality of the crus of the helix", "Abnormality of the curvature of the cornea", "Abnormality of the curvature of the vertebral column", "Abnormality of the dentition", "Abnormality of the diaphragm", "Abnormality of the diencephalon", "Abnormality of the distal phalanges of the toes", "Abnormality of the distal phalanx of the thumb", "Abnormality of the dorsal column of the spinal cord", "Abnormality of the elbow", "Abnormality of the endometrium", "Abnormality of the epididymis", "Abnormality of the epiphyses of the distal phalanx of finger", "Abnormality of the external nose", "Abnormality of the extraocular muscles", "Abnormality of the extrinsic pathway", "Abnormality of the female genitalia", "Abnormality of the fetal cardiovascular system", "Abnormality of the fifth metatarsal bone", "Abnormality of the fontanelles or cranial sutures", "Abnormality of the foot musculature", "Abnormality of the forearm", "Abnormality of the forehead", "Abnormality of the frontal hairline", "Abnormality of the gallbladder", "Abnormality of the gastric mucosa", "Abnormality of the gingiva", "Abnormality of the glabella", "Abnormality of the glenoid fossa", "Abnormality of the hairline", "Abnormality of the hallux", "Abnormality of the helix", "Abnormality of the hepatic vasculature", "Abnormality of the humeroradial joint", "Abnormality of the humerus", "Abnormality of the hypothalamus pituitary axis", "Abnormality of the hypothenar eminence", "Abnormality of the incisor", "Abnormality of the inner ear", "Abnormality of the internal auditory canal", "Abnormality of the intervertebral disk", "Abnormality of the intrahepatic bile duct", "Abnormality of the intrinsic pathway", "Abnormality of the ischium", "Abnormality of the kidney", "Abnormality of the knee", "Abnormality of the larynx", "Abnormality of the lens", "Abnormality of the leydig cells", "Abnormality of the liver", "Abnormality of the lower urinary tract", "Abnormality of the lymph nodes", "Abnormality of the lymphatic system", "Abnormality of the mastoid", "Abnormality of the maxilla", "Abnormality of the menstrual cycle", "Abnormality of the metacarpal bones", "Abnormality of the metaphysis", "Abnormality of the metopic suture", "Abnormality of the middle ear", "Abnormality of the middle ear ossicles", "Abnormality of the middle phalanges of the toes", "Abnormality of the middle phalanx of the 5th finger", "Abnormality of the midface", "Abnormality of the mitochondrion", "Abnormality of the musculature of the hand", "Abnormality of the musculature of the limbs", "Abnormality of the musculature of the lower limbs", "Abnormality of the musculature of the thigh", "Abnormality of the musculature of the upper arm", "Abnormality of the musculature of the upper limbs", "Abnormality of the nail", "Abnormality of the nasal alae", "Abnormality of the nasal bone", "Abnormality of the nasal cavity", "Abnormality of the nasal dorsum", "Abnormality of the nasal septum", "Abnormality of the nasal skeleton", "Abnormality of the nasal tip", "Abnormality of the nasolabial region", "Abnormality of the neck", "Abnormality of the odontoid process", "Abnormality of the optic nerve", "Abnormality of the outer ear", "Abnormality of the ovary", "Abnormality of the palm", "Abnormality of the palpebral fissures", "Abnormality of the pancreas", "Abnormality of the parathyroid gland", "Abnormality of the parathyroid morphology", "Abnormality of the periorbital region", "Abnormality of the peripheral nervous system", "Abnormality of the peritoneum", "Abnormality of the periungual region", "Abnormality of the phalanges of the 2nd finger", "Abnormality of the phalanges of the hallux", "Abnormality of the phalanges of the toes", "Abnormality of the pharynx", "Abnormality of the philtrum", "Abnormality of the pineal gland", "Abnormality of the pinna", "Abnormality of the pituitary gland", "Abnormality of the plantar skin of foot", "Abnormality of the posterior pituitary", "Abnormality of the protein c anticoagulant pathway", "Abnormality of the proximal phalanx of the thumb", "Abnormality of the pubic bone", "Abnormality of the pubic hair", "Abnormality of the pulmonary artery", "Abnormality of the pulmonary vasculature", "Abnormality of the pulmonary veins", "Abnormality of the pylorus", "Abnormality of the radial head", "Abnormality of the radioulnar joints", "Abnormality of the ribs", "Abnormality of the scrotum", "Abnormality of the sense of smell", "Abnormality of the septum pellucidum", "Abnormality of the shoulder girdle musculature", "Abnormality of the skull base", "Abnormality of the small intestine", "Abnormality of the spinal cord", "Abnormality of the spinocerebellar tracts", "Abnormality of the spleen", "Abnormality of the stapes", "Abnormality of the subungual region", "Abnormality of the supraorbital ridges", "Abnormality of the synovia", "Abnormality of the tarsal bones", "Abnormality of the temporomandibular joint", "Abnormality of the testis size", "Abnormality of the thenar eminence", "Abnormality of the thoracic cavity", "Abnormality of the thymus", "Abnormality of the thyroid gland", "Abnormality of the tongue", "Abnormality of the tongue muscle", "Abnormality of the tonsils", "Abnormality of the tragus", "Abnormality of the ulna", "Abnormality of the umbilical cord", "Abnormality of the upper arm", "Abnormality of the upper respiratory tract", "Abnormality of the ureter", "Abnormality of the urethra", "Abnormality of the urinary system physiology", "Abnormality of the uterus", "Abnormality of the vasculature of the eye", "Abnormality of the vertebral endplates", "Abnormality of the vestibulocochlear nerve", "Abnormality of the voice", "Abnormality of the wrist", "Abnormality of the zygomatic bone", "Abnormality of thyroid physiology", "Abnormality of tibia morphology", "Abnormality of toe", "Abnormality of ulnar metaphysis", "Abnormality of upper limb epiphysis morphology", "Abnormality of upper limb joint", "Abnormality of upper limb metaphysis", "Abnormality of upper lip", "Abnormality of upper lip vermillion", "Abnormality of urinary uric acid concentration", "Abnormality of urine calcium concentration", "Abnormality of urine catecholamine concentration", "Abnormality of urine homeostasis", "Abnormality of visual evoked potentials", "Abnormality of vitamin a metabolism", "Abnormality of vitamin b metabolism", "Abnormality of vitamin b12 metabolism", "Abnormality of vitamin d metabolism", "Abnormality of vitamin e metabolism", "Abnormality of vitamin k metabolism", "Abnormality of vitamin metabolism", "Abnormality on pulmonary function testing", "Abnormally folded helix", "Abnormally large globe", "Abnormally lax or hyperextensible skin", "Abnormally low pitched voice", "Abnormally ossified vertebrae", "Abnormally shaped carpal bones", "Abscess", "Absence of pubertal development", "Absence of secondary sex characteristics", "Absence of subcutaneous fat", "Absence of the sacrum", "Absent axillary hair", "Absent brainstem auditory responses", "Absent distal phalanges", "Absent earlobe", "Absent epiphyses", "Absent eyebrow", "Absent facial hair", "Absent fingernail", "Absent forearm bone", "Absent frontal sinuses", "Absent hair", "Absent hand", "Absent hypoplastic paranasal sinuses", "Absent nares", "Absent nipple", "Absent or minimally ossified vertebral bodies", "Absent outer dynein arms", "Absent palmar crease", "Absent septum pellucidum", "Absent shortened dynein arms", "Absent speech", "Absent sternal ossification", "Absent testis", "Absent thumb", "Absent thumbnail", "Absent tibia", "Absent toe", "Absent toenail", "Acanthocytosis", "Acantholysis", "Acanthosis nigricans", "Accelerated atherosclerosis", "Accelerated skeletal maturation", "Accessory oral frenulum", "Accessory spleen", "Acetabular dysplasia", "Acetabular spurs", "Achilles tendon contracture", "Acidemia", "Acne", "Acne inversa", "Acquired abnormal hair pattern", "Acral blistering", "Acral ulceration", "Acromesomelia", "Acroparesthesia", "Action tremor", "Acute coronary syndrome", "Acute encephalopathy", "Acute hepatic failure", "Acute kidney injury", "Acute leukemia", "Acute lymphoblastic leukemia", "Acute myeloid leukemia", "Acute pancreatitis", "Acute phase response", "Addictive behavior", "Adducted thumb", "Adenocarcinoma of the colon", "Adenocarcinoma of the intestines", "Adenocarcinoma of the small intestine", "Adenoma sebaceum", "Adenomatous colonic polyposis", "Adipose tissue loss", "Adrenal hyperplasia", "Adrenal hypoplasia", "Adrenal insufficiency", "Adrenal overactivity", "Adrenocortical abnormality", "Adrenocortical carcinoma", "Adrenocorticotropic hormone deficiency", "Adrenocorticotropic hormone excess", "Adrenocorticotropin deficient adrenal insufficiency", "Adult onset", "Advanced eruption of teeth", "Agammaglobulinemia", "Aganglionic megacolon", "Agenesis of central incisor", "Agenesis of cerebellar vermis", "Agenesis of corpus callosum", "Agenesis of incisor", "Agenesis of permanent teeth", "Aggressive behavior", "Agitation", "Agnosia", "Agyria", "Airway obstruction", "Akinesia", "Alacrima", "Albinism", "Albuminuria", "Alexia", "Alkalosis", "Allergic rhinitis", "Allergy", "Alopecia", "Alopecia of scalp", "Alopecia totalis", "Alopecia universalis", "Alternating esotropia", "Alveolar cell carcinoma", "Alveolar ridge overgrowth", "Alzheimer disease", "Amaurosis fugax", "Ambiguous genitalia", "Ambiguous genitalia female", "Ambiguous genitalia male", "Amblyopia", "Amegakaryocytic thrombocytopenia", "Amelogenesis imperfecta", "Amenorrhea", "Aminoaciduria", "Amniotic constriction ring", "Amyloidosis", "Amyotrophic lateral sclerosis", "Anal atresia", "Anal stenosis", "Anaphylactic shock", "Anarthria", "Anasarca", "Anemia of inadequate production", "Anencephaly", "Angina pectoris", "Angioedema", "Angiofibromas", "Angioid streaks of the fundus", "Angiokeratoma", "Angular cheilitis", "Anhidrosis", "Aniridia", "Anisocoria", "Anisocytosis", "Anisopoikilocytosis", "Anisospondyly", "Ankle clonus", "Ankle flexion contracture", "Ankle weakness", "Ankyloblepharon", "Ankyloglossia", "Ankylosis", "Annular pancreas", "Anodontia", "Anomalous trichromacy", "Anomic aphasia", "Anonychia", "Anophthalmia", "Anorectal anomaly", "Anorexia", "Anosmia", "Anotia", "Antenatal onset", "Anterior open bite malocclusion", "Anterior pituitary dysgenesis", "Anterior plagiocephaly", "Anterior rib cupping", "Anterior uveitis", "Anteriorly placed anus", "Anteverted ears", "Antineutrophil antibody positivity", "Antinuclear antibody positivity", "Antiphospholipid antibody positivity", "Aortic aneurysm", "Aortic arch aneurysm", "Aortic atherosclerotic lesion", "Aortic dissection", "Aortic regurgitation", "Aortic root aneurysm", "Aortic valve calcification", "Aortic valve stenosis", "Aphasia", "Aphthous ulcer", "Aplasia cutis congenita", "Aplasia cutis congenita of scalp", "Aplasia cutis congenita on trunk or limbs", "Aplasia cutis congenita over the scalp vertex", "Aplasia hypoplasia affecting bones of the axial skeleton", "Aplasia hypoplasia affecting the anterior segment of the eye", "Aplasia hypoplasia affecting the eye", "Aplasia hypoplasia affecting the fundus", "Aplasia hypoplasia involving bones of the feet", "Aplasia hypoplasia involving bones of the lower limbs", "Aplasia hypoplasia involving bones of the thorax", "Aplasia hypoplasia involving bones of the upper limbs", "Aplasia hypoplasia involving forearm bones", "Aplasia hypoplasia involving the carpal bones", "Aplasia hypoplasia involving the femoral head and neck", "Aplasia hypoplasia involving the metacarpal bones", "Aplasia hypoplasia involving the musculature of the upper limbs", "Aplasia hypoplasia involving the nose", "Aplasia hypoplasia involving the pelvis", "Aplasia hypoplasia involving the sinuses", "Aplasia hypoplasia involving the skeletal musculature", "Aplasia hypoplasia involving the skeleton", "Aplasia hypoplasia involving the vertebral column", "Aplasia hypoplasia of fingers", "Aplasia hypoplasia of metatarsal bones", "Aplasia hypoplasia of the 2nd finger", "Aplasia hypoplasia of the 4th metacarpal", "Aplasia hypoplasia of the 5th finger", "Aplasia hypoplasia of the 5th metacarpal", "Aplasia hypoplasia of the abdominal wall musculature", "Aplasia hypoplasia of the bladder", "Aplasia hypoplasia of the breasts", "Aplasia hypoplasia of the capital femoral epiphysis", "Aplasia hypoplasia of the cerebellar vermis", "Aplasia hypoplasia of the cerebellum", "Aplasia hypoplasia of the cerebral white matter", "Aplasia hypoplasia of the clavicles", "Aplasia hypoplasia of the colon", "Aplasia hypoplasia of the distal phalanges of the hand", "Aplasia hypoplasia of the distal phalanx of the thumb", "Aplasia hypoplasia of the ear", "Aplasia hypoplasia of the earlobes", "Aplasia hypoplasia of the epiglottis", "Aplasia hypoplasia of the extremities", "Aplasia hypoplasia of the eyebrow", "Aplasia hypoplasia of the eyelid", "Aplasia hypoplasia of the femur", "Aplasia hypoplasia of the fibula", "Aplasia hypoplasia of the gallbladder", "Aplasia hypoplasia of the hallux", "Aplasia hypoplasia of the humerus", "Aplasia hypoplasia of the lungs", "Aplasia hypoplasia of the middle phalanges of the toes", "Aplasia hypoplasia of the nails", "Aplasia hypoplasia of the nasal bone", "Aplasia hypoplasia of the nasal septum", "Aplasia hypoplasia of the nipples", "Aplasia hypoplasia of the optic nerve", "Aplasia hypoplasia of the ovary", "Aplasia hypoplasia of the palmar creases", "Aplasia hypoplasia of the patella", "Aplasia hypoplasia of the phalanges of the 2nd finger", "Aplasia hypoplasia of the phalanges of the hand", "Aplasia hypoplasia of the phalanges of the thumb", "Aplasia hypoplasia of the phalanges of the toes", "Aplasia hypoplasia of the proximal phalanges of the hand", "Aplasia hypoplasia of the pubic bone", "Aplasia hypoplasia of the radius", "Aplasia hypoplasia of the retina", "Aplasia hypoplasia of the ribs", "Aplasia hypoplasia of the sacrum", "Aplasia hypoplasia of the scapulae", "Aplasia hypoplasia of the skin", "Aplasia hypoplasia of the spleen", "Aplasia hypoplasia of the sternum", "Aplasia hypoplasia of the thumb", "Aplasia hypoplasia of the thymus", "Aplasia hypoplasia of the thyroid gland", "Aplasia hypoplasia of the tibia", "Aplasia hypoplasia of the tongue", "Aplasia hypoplasia of the tragus", "Aplasia hypoplasia of the ulna", "Aplasia hypoplasia of the uterus", "Aplasia hypoplasia of the uvula", "Aplasia hypoplasia of the vagina", "Aplasia hypoplasia of toe", "Aplasia involving bones of the extremities", "Aplasia involving bones of the lower limbs", "Aplasia of metacarpal bones", "Aplasia of the fingers", "Aplasia of the middle phalanx of the hand", "Aplasia of the phalanges of the hand", "Aplasia of the phalanges of the toes", "Aplasia of the proximal phalanges of the hand", "Aplasia of the semicircular canal", "Aplasia of the uterus", "Aplastic anemia", "Aplastic clavicle", "Aplastic hypoplastic lacrimal glands", "Aplastic hypoplastic toenail", "Apnea", "Apneic episodes in infancy", "Apneic episodes precipitated by illness fatigue stress", "Appendicular hypotonia", "Apraxia", "Aqueductal stenosis", "Arachnodactyly", "Arachnoid hemangiomatosis", "Areflexia", "Areflexia of lower limbs", "Arm dystonia", "Arnold chiari malformation", "Arnold chiari type i malformation", "Arrhinencephaly", "Arteria lusoria", "Arterial dissection", "Arterial rupture", "Arterial stenosis", "Arterial thrombosis", "Arteriosclerosis", "Arteriovenous malformation", "Arthralgia", "Arthritis", "Arthrogryposis multiplex congenita", "Arthropathy", "Ascending aortic dissection", "Ascending tubular aorta aneurysm", "Ascites", "Aspiration", "Aspiration pneumonia", "Asterixis", "Asthenia", "Asthma", "Astigmatism", "Astrocytoma", "Astrocytosis", "Asymmetric growth", "Asymmetric septal hypertrophy", "Asymmetry of spinal facet joints", "Asymmetry of the ears", "Atelectasis", "Athetosis", "Atlantoaxial abnormality", "Atlantoaxial dislocation", "Atlantoaxial instability", "Atonic seizure", "Atopic dermatitis", "Atresia of the external auditory canal", "Atrial arrhythmia", "Atrial flutter", "Atrioventricular canal defect", "Atrophic scars", "Atrophy degeneration affecting the brainstem", "Atrophy degeneration affecting the central nervous system", "Atrophy degeneration affecting the cerebrum", "Atrophy degeneration involving the caudate nucleus", "Atrophy degeneration involving the corticospinal tracts", "Atrophy degeneration involving the spinal cord", "Atrophy of alveolar ridges", "Attention deficit hyperactivity disorder", "Attenuation of retinal blood vessels", "Atypical absence seizure", "Auditory hallucinations", "Autism", "Autistic behavior", "Autoamputation", "Autoamputation of digits", "Autoimmune antibody positivity", "Autoimmune hemolytic anemia", "Autoimmune thrombocytopenia", "Autoimmunity", "Autophagic vacuoles", "Autosomal dominant germline de novo mutation", "Avascular necrosis", "Avascular necrosis of the capital femoral epiphysis", "Axial dystonia", "Axial muscle weakness", "Axillary pterygium", "Axonal degeneration", "Axonal degeneration regeneration", "Axonal loss", "Axonal regeneration", "Azoospermia", "B cell lymphoma", "B lymphocytopenia", "Babinski sign", "Back pain", "Bacterial endocarditis", "Barrel shaped chest", "Barrett esophagus", "Basal cell carcinoma", "Basal ganglia calcification", "Basal ganglia cysts", "Basal ganglia gliosis", "Beaded ribs", "Beaking of vertebral bodies", "Bell shaped thorax", "Benign neoplasm of the central nervous system", "Bicarbonaturia", "Biconcave vertebral bodies", "Bicornuate uterus", "Bifid epiglottis", "Bifid nasal tip", "Bifid ribs", "Bifid scrotum", "Bifid tongue", "Bifid uterus", "Bifid uvula", "Bilateral cleft lip", "Bilateral cleft lip and palate", "Bilateral cleft palate", "Bilateral coxa valga", "Bilateral cryptorchidism", "Bilateral external ear deformity", "Bilateral microphthalmos", "Bilateral polymicrogyria", "Bilateral ptosis", "Bilateral sensorineural hearing impairment", "Bilateral single transverse palmar creases", "Bilateral talipes equinovarus", "Bilateral tonic clonic seizure", "Bilateral tonic clonic seizure with focal onset", "Bilateral tonic clonic seizure with generalized onset", "Bile duct proliferation", "Biliary atresia", "Biliary cirrhosis", "Biliary tract abnormality", "Biliary tract neoplasm", "Bimanual synkinesia", "Biparietal narrowing", "Bird like facies", "Birth length greater than 97th percentile", "Birth length less than 3rd percentile", "Biventricular hypertrophy", "Bladder diverticulum", "Bladder neoplasm", "Bleeding with minor or no trauma", "Blepharitis", "Blepharophimosis", "Blindness", "Blistering by anatomical location", "Blistering by histological location", "Bloodstream infectious agent", "Bloody diarrhea", "Blue irides", "Blue nevus", "Blue sclerae", "Blurred vision", "Bone cyst", "Bone fracture", "Bone marrow foam cells", "Bone marrow hypercellularity", "Bone marrow hypocellularity", "Bone pain", "Bone spicule pigmentation of the retina", "Bowel diverticulosis", "Bowing of the arm", "Bowing of the legs", "Brachycephaly", "Brachydactyly", "Bradycardia", "Bradykinesia", "Brain imaging abnormality", "Brain neoplasm", "Brain stem compression", "Branchial anomaly", "Branchial cyst", "Branchial fistula", "Breast aplasia", "Breast carcinoma", "Breast hypoplasia", "Breathing dysregulation", "Breech presentation", "Brisk reflexes", "Brittle hair", "Broad alveolar ridges", "Broad based gait", "Broad chin", "Broad clavicles", "Broad columella", "Broad distal phalanx of finger", "Broad eyebrow", "Broad face", "Broad femoral neck", "Broad finger", "Broad foot", "Broad forehead", "Broad hallux phalanx", "Broad jaw", "Broad long bones", "Broad metacarpals", "Broad nasal tip", "Broad neck", "Broad palm", "Broad phalanx of the toes", "Broad philtrum", "Broad ribs", "Broad thumb", "Broad toe", "Bronchiectasis", "Bronchitis", "Bronchomalacia", "Bronchospasm", "Bruising susceptibility", "Brushfield spots", "Bruxism", "Bulbar palsy", "Bulbar signs", "Bulbous nose", "Bull s eye maculopathy", "Bundle branch block", "Buphthalmos", "Burkitt lymphoma", "Butterfly vertebrae", "Cachexia", "Caesarian section", "Cafe au lait spot", "Calcific stippling", "Calcification of the aorta", "Calcinosis", "Calcium nephrolithiasis", "Calcium oxalate nephrolithiasis", "Calf muscle pseudohypertrophy", "Calvarial hyperostosis", "Calvarial osteosclerosis", "Calvarial skull defect", "Camptodactyly of toe", "Capillary hemangioma", "Capillary malformation", "Capitate hamate fusion", "Carcinoid tumor", "Carcinoma", "Cardiac arrest", "Cardiac conduction abnormality", "Cardiac diverticulum", "Cardiac shunt", "Cardiac valve calcification", "Cardiomegaly", "Cardiorespiratory arrest", "Cardiovascular calcification", "Carious teeth", "Carpal bone hypoplasia", "Carpal synostosis", "Cataplexy", "Caudate atrophy", "Cavernous hemangioma", "Cavum septum pellucidum", "Celiac disease", "Cellular immunodeficiency", "Cellulitis", "Central adrenal insufficiency", "Central apnea", "Central diabetes insipidus", "Central hypothyroidism", "Central hypoventilation", "Central nervous system cyst", "Central primitive neuroectodermal tumor", "Central scotoma", "Central sleep apnea", "Central y shaped metacarpal", "Centrally nucleated skeletal muscle fibers", "Centrocecal scotoma", "Cerebellar atrophy", "Cerebellar cortical atrophy", "Cerebellar cyst", "Cerebellar dysplasia", "Cerebellar hemorrhage", "Cerebellar hypoplasia", "Cerebellar malformation", "Cerebellar vermis atrophy", "Cerebral amyloid angiopathy", "Cerebral calcification", "Cerebral cortical atrophy", "Cerebral dysmyelination", "Cerebral edema", "Cerebral hamartoma", "Cerebral hemorrhage", "Cerebral hypomyelination", "Cerebral hypoplasia", "Cerebral inclusion bodies", "Cerebral palsy", "Cerebral venous thrombosis", "Cerebral visual impairment", "Cerebral white matter atrophy", "Cerebral white matter hypoplasia", "Cervical kyphosis", "Cervical myelopathy", "Cervical ribs", "Cervical spinal canal stenosis", "Cervical spine instability", "Cervical subluxation", "Cessation of head growth", "Cheilitis", "Cherry red spot of the macula", "Chest pain", "Chilblains", "Childhood onset", "Childhood onset sensorineural hearing impairment", "Childhood onset truncal obesity", "Chills", "Choanal stenosis", "Choking episodes", "Cholangitis", "Cholecystitis", "Cholestasis", "Cholestatic liver disease", "Chondrocalcinosis", "Chondrosarcoma", "Chordee", "Chorea", "Choreoathetosis", "Choriocarcinoma", "Chorioretinal atrophy", "Chorioretinal coloboma", "Chorioretinal degeneration", "Chorioretinal dysplasia", "Chorioretinal hypopigmentation", "Choroid plexus carcinoma", "Choroid plexus cyst", "Choroidal melanoma", "Choroidal neovascularization", "Choroideremia", "Chromosomal breakage induced by crosslinking agents", "Chromosomal breakage induced by ionizing radiation", "Chromosome breakage", "Chronic atrophic gastritis", "Chronic axonal neuropathy", "Chronic bronchitis", "Chronic constipation", "Chronic diarrhea", "Chronic fatigue", "Chronic hemolytic anemia", "Chronic hepatic failure", "Chronic infection", "Chronic kidney disease", "Chronic leukemia", "Chronic lung disease", "Chronic lymphatic leukemia", "Chronic mucocutaneous candidiasis", "Chronic neutropenia", "Chronic noninfectious lymphadenopathy", "Chronic oral candidiasis", "Chronic otitis media", "Chronic pulmonary obstruction", "Chronic rhinitis", "Chronic sinusitis", "Chylothorax", "Cigarette paper scars", "Cirrhosis", "Cleft hard palate", "Cleft lip", "Cleft soft palate", "Cleft upper lip", "Clinodactyly", "Clitoral hypoplasia", "Clonic seizure", "Clonus", "Cloverleaf skull", "Clubbing", "Clubbing of fingers", "Clubbing of toes", "Clumsiness", "Cns demyelination", "Cns hypomyelination", "Coarctation of aorta", "Coarse facial features", "Coarse hair", "Cochlear malformation", "Cognitive impairment", "Cogwheel rigidity", "Cold induced muscle cramps", "Colitis", "Collectionism", "Coloboma", "Colon cancer", "Color vision defect", "Color vision test abnormality", "Colorectal polyposis", "Colpocephaly", "Coma", "Combined immunodeficiency", "Communicating hydrocephalus", "Complete atrioventricular canal defect", "Complete duplication of phalanx of hand", "Complex febrile seizure", "Concave nail", "Concave nasal ridge", "Concentric hypertrophic cardiomyopathy", "Cone cone rod dystrophy", "Cone shaped epiphyses of the phalanges of the hand", "Cone shaped epiphysis", "Confetti like hypopigmented macules", "Confusion", "Congenital adrenal hyperplasia", "Congenital bilateral hip dislocation", "Congenital blindness", "Congenital contracture", "Congenital craniofacial dysostosis", "Congenital diaphragmatic hernia", "Congenital hemolytic anemia", "Congenital hepatic fibrosis", "Congenital hip dislocation", "Congenital hypothyroidism", "Congenital ichthyosiform erythroderma", "Congenital localized absence of skin", "Congenital malformation of the great arteries", "Congenital malformation of the left heart", "Congenital malformation of the right heart", "Congenital muscular dystrophy", "Congenital muscular torticollis", "Congenital nonbullous ichthyosiform erythroderma", "Congenital nystagmus", "Congenital onset", "Congenital posterior urethral valve", "Congenital ptosis", "Congenital sensorineural hearing impairment", "Congenital stationary night blindness", "Congenital thrombocytopenia", "Congestive heart failure", "Conical tooth", "Conjugated hyperbilirubinemia", "Conjunctival hamartoma", "Connective tissue nevi", "Conspicuously happy disposition", "Constipation", "Constitutional symptom", "Constriction of peripheral visual field", "Contiguous gene syndrome", "Contractures involving the joints of the feet", "Contractures of the joints of the lower limbs", "Contractures of the joints of the upper limbs", "Contractures of the large joints", "Convex nasal ridge", "Coombs positive hemolytic anemia", "Cor pulmonale", "Corneal dystrophy", "Corneal erosion", "Corneal neovascularization", "Corneal opacity", "Corneal scarring", "Corneal ulceration", "Coronal cleft vertebrae", "Coronal craniosynostosis", "Coronary artery atherosclerosis", "Corpus callosum atrophy", "Cortical cataract", "Cortical dysplasia", "Cortical myoclonus", "Cortical thickening of long bone diaphyses", "Corticospinal tract hypoplasia", "Cough", "Coxa valga", "Coxa vara", "Crackles", "Cranial asymmetry", "Cranial hyperostosis", "Cranial nerve compression", "Craniofacial asymmetry", "Craniofacial dysostosis", "Craniofacial hyperostosis", "Craniofacial osteosclerosis", "Craniosynostosis", "Crumpled long bones", "Cryptorchidism", "Csf lymphocytic pleiocytosis", "Csf pleocytosis", "Cubitus valgus", "Cupped ear", "Cupped ribs", "Curly eyelashes", "Curly hair", "Cutaneous abscess", "Cutaneous amyloidosis", "Cutaneous cyst", "Cutaneous finger syndactyly", "Cutaneous melanoma", "Cutaneous photosensitivity", "Cutaneous syndactyly", "Cutaneous syndactyly of toes", "Cutis laxa", "Cutis marmorata", "Cyanosis", "Cyanotic episode", "Cyclopia", "Cystathioninemia", "Cystic hygroma", "Cystic liver disease", "Cystic renal dysplasia", "Cystinuria", "Cystoid macular edema", "Cytochrome c oxidase negative muscle fibers", "Dark urine", "Death in adolescence", "Death in adulthood", "Death in childhood", "Death in infancy", "Decerebrate rigidity", "Decreased absent ankle reflexes", "Decreased activity of mitochondrial complex i", "Decreased activity of mitochondrial complex ii", "Decreased activity of mitochondrial complex iii", "Decreased activity of mitochondrial complex iv", "Decreased activity of the pyruvate dehydrogenase complex", "Decreased adipose tissue", "Decreased calvarial ossification", "Decreased cd4 cd8 ratio", "Decreased cervical spine flexion due to contractures of posterior cervical muscles", "Decreased cervical spine mobility", "Decreased circulating acth level", "Decreased circulating aldosterone level", "Decreased circulating androgen concentration", "Decreased circulating antibody level", "Decreased circulating copper concentration", "Decreased circulating cortisol level", "Decreased circulating follicle stimulating hormone concentration", "Decreased circulating gaba concentration", "Decreased circulating gonadotropin concentration", "Decreased circulating iga level", "Decreased circulating igg level", "Decreased circulating igg subclass level", "Decreased circulating level of specific antibody", "Decreased circulating progesterone", "Decreased circulating total iga", "Decreased circulating total igg", "Decreased circulating total igm", "Decreased corneal reflex", "Decreased facial expression", "Decreased fertility", "Decreased fertility in females", "Decreased fertility in males", "Decreased head circumference", "Decreased lacrimation", "Decreased ldl cholesterol concentration", "Decreased libido", "Decreased light and dark adapted electroretinogram amplitude", "Decreased lymphocyte apoptosis", "Decreased lymphocyte proliferation in response to mitogen", "Decreased mean corpuscular volume", "Decreased methylcobalamin", "Decreased muscle mass", "Decreased number of large peripheral myelinated nerve fibers", "Decreased number of peripheral myelinated nerve fibers", "Decreased palmar creases", "Decreased patellar reflex", "Decreased plasma carnitine", "Decreased proportion of cd3 positive t cells", "Decreased proportion of cd4 positive helper t cells", "Decreased pulmonary function", "Decreased serum complement c3", "Decreased serum complement c4", "Decreased serum insulin like growth factor 1", "Decreased serum iron", "Decreased size of nerve terminals", "Decreased specific anti polysaccharide antibody level", "Decreased specific antibody response to protein vaccine", "Decreased specific antibody response to vaccination", "Decreased specific pneumococcal antibody level", "Decreased testicular size", "Decreased urine output", "Deep palmar crease", "Deep philtrum", "Deep plantar creases", "Deep set nails", "Deep venous thrombosis", "Deeply set eye", "Defective dna repair after ultraviolet radiation damage", "Defective t cell proliferation", "Deformed rib cage", "Deformed sella turcica", "Deformed tarsal bones", "Degeneration of the lateral corticospinal tracts", "Degeneration of the striatum", "Dehydration", "Delayed ability to roll over", "Delayed ability to sit", "Delayed ability to stand", "Delayed ability to walk", "Delayed closure of the anterior fontanelle", "Delayed cns myelination", "Delayed cranial suture closure", "Delayed epiphyseal ossification", "Delayed eruption of permanent teeth", "Delayed eruption of primary teeth", "Delayed eruption of teeth", "Delayed fine motor development", "Delayed gross motor development", "Delayed menarche", "Delayed myelination", "Delayed ossification of carpal bones", "Delayed puberty", "Delayed social development", "Delirium", "Delusions", "Dementia", "Demyelinating peripheral neuropathy", "Dental crowding", "Dental malocclusion", "Depletion of mitochondrial dna in muscle tissue", "Deposits immunoreactive to beta amyloid protein", "Depressed nasal bridge", "Depressed nasal ridge", "Depressed nasal tip", "Depression", "Dermal atrophy", "Dermal translucency", "Dermatological manifestations of systemic disorders", "Dermoid cyst", "Descending aortic dissection", "Desquamation of skin soon after birth", "Developmental cataract", "Developmental glaucoma", "Developmental regression", "Developmental stagnation", "Deviated nasal septum", "Deviation of the 2nd finger", "Deviation of the 3rd finger", "Deviation of the hallux", "Deviation of the hand or of fingers of the hand", "Deviation of the thumb", "Deviation of toes", "Diabetes insipidus", "Dialeptic seizure", "Diaphragmatic eventration", "Diaphragmatic paralysis", "Diaphragmatic weakness", "Diaphyseal sclerosis", "Diaphyseal thickening", "Diarrhea", "Diastasis recti", "Diastema", "Dicarboxylic aciduria", "Difficulty climbing stairs", "Difficulty in tongue movements", "Difficulty running", "Difficulty standing", "Difficulty walking", "Diffuse alveolar hemorrhage", "Diffuse cerebellar atrophy", "Diffuse cerebral atrophy", "Diffuse mesangial sclerosis", "Diffuse white matter abnormalities", "Digenic inheritance", "Dilatation of the cerebral artery", "Dilatation of the ventricular cavity", "Dilated cardiomyopathy", "Dilated fourth ventricle", "Dilated third ventricle", "Dilation of lateral ventricles", "Dilation of virchow robin spaces", "Diminished ability to concentrate", "Diminished motivation", "Diminished movement", "Dimple chin", "Diplopia", "Disinhibition", "Displacement of the urethral meatus", "Disproportionate short limb short stature", "Disproportionate short stature", "Disproportionate short trunk short stature", "Disproportionate tall stature", "Disseminated intravascular coagulation", "Distal amyotrophy", "Distal arthrogryposis", "Distal joint laxity", "Distal lower limb amyotrophy", "Distal lower limb muscle weakness", "Distal muscle weakness", "Distal peripheral sensory neuropathy", "Distal sensory impairment", "Distal sensory impairment of all modalities", "Distal sensory loss of all modalities", "Distal upper limb amyotrophy", "Distal upper limb muscle weakness", "Disturbance of facial expression", "Dolichocephaly", "Down sloping shoulders", "Downslanted palpebral fissures", "Downturned corners of mouth", "Drowsiness", "Drusen", "Dry hair", "Dry skin", "Duodenal adenocarcinoma", "Duodenal atresia", "Duodenal stenosis", "Duplicated collecting system", "Duplication involving bones of the feet", "Duplication of hand bones", "Duplication of phalanx of hallux", "Duplication of the distal phalanx of hand", "Duplication of the distal phalanx of the thumb", "Duplication of thumb phalanx", "Dysarthria", "Dyscalculia", "Dyschromatopsia", "Dysdiadochokinesis", "Dysesthesia", "Dysgammaglobulinemia", "Dysgenesis of the cerebellar vermis", "Dysgenesis of the hippocampus", "Dysgerminoma", "Dysgraphia", "Dyskinesia", "Dyslexia", "Dysmenorrhea", "Dysmetria", "Dysmetric saccades", "Dysostosis multiplex", "Dyspareunia", "Dysphagia", "Dysphasia", "Dysphonia", "Dysplasia of the femoral head", "Dysplastic corpus callosum", "Dyspnea", "Dystonia", "Dystrophic fingernails", "Dystrophic toenail", "Dysuria", "Ear pain", "Early onset absence seizures", "Early onset of sexual maturation", "Easy fatigability", "Ecchymosis", "Echolalia", "Eclabion", "Eclampsia", "Ectodermal dysplasia", "Ectopia lentis", "Ectopia pupillae", "Ectopic anus", "Ectopic calcification", "Ectopic kidney", "Ectrodactyly", "Ectropion", "Ectropion of lower eyelids", "Eczema", "Eczematoid dermatitis", "Edema of the dorsum of feet", "Edema of the dorsum of hands", "Eeg with abnormally slow frequencies", "Eeg with burst suppression", "Eeg with continuous slow activity", "Eeg with focal epileptiform discharges", "Eeg with focal sharp slow waves", "Eeg with focal sharp waves", "Eeg with focal spike waves", "Eeg with focal spikes", "Eeg with frontal epileptiform discharges", "Eeg with generalized sharp slow waves", "Eeg with generalized slow activity", "Eeg with irregular generalized spike and wave complexes", "Eeg with multifocal slow activity", "Eeg with polyspike wave complexes", "Eeg with spike wave complexes", "Elbow ankylosis", "Elbow flexion contracture", "Elevated alkaline phosphatase of bone origin", "Elevated calcitonin", "Elevated circulating alanine aminotransferase concentration", "Elevated circulating aspartate aminotransferase concentration", "Elevated circulating follicle stimulating hormone level", "Elevated circulating glutaric acid concentration", "Elevated circulating growth hormone concentration", "Elevated circulating long chain fatty acid concentration", "Elevated circulating parathyroid hormone level", "Elevated circulating thyroid stimulating hormone concentration", "Elevated creatine kinase after exercise", "Elevated diastolic blood pressure", "Elevated gamma glutamyltransferase level", "Elevated hemoglobin a1c", "Elevated hepatic transaminase", "Elevated lactate pyruvate ratio", "Elevated mean arterial pressure", "Elevated proportion of cd4 negative cd8 negative alpha beta regulatory t cells", "Elevated pulmonary artery pressure", "Elevated serum acid phosphatase", "Elevated systolic blood pressure", "Elevated tissue non specific alkaline phosphatase", "Elevated total serum tryptase", "Elevated urinary carboxylic acid", "Elevated urinary delta aminolevulinic acid", "Elevated urinary dicarboxylic acid level", "Elevated urinary monocarboxylic acid level", "Elfin facies", "Elliptocytosis", "Elongated superior cerebellar peduncle", "Embryonal neoplasm", "Embryonal renal neoplasm", "Emg abnormality", "Emg axonal abnormality", "Emg chronic denervation signs", "Emg decremental response of compound muscle action potential to repetitive nerve stimulation", "Emg impaired neuromuscular transmission", "Emg myopathic abnormalities", "Emg neuropathic changes", "Emg slow motor conduction", "Emotional lability", "Emphysema", "Enamel hypoplasia", "Encephalocele", "Encephalopathy", "Enchondroma", "Endocardial fibroelastosis", "Endocardial fibrosis", "Endocarditis", "Enlarged cerebellum", "Enlarged cisterna magna", "Enlarged joints", "Enlarged kidney", "Enlarged metaphyses", "Enlarged ovaries", "Enlarged posterior fossa", "Enlarged thorax", "Enlarged tonsils", "Enlargement of the costochondral junction", "Enlargement of the wrists", "Enterocolitis", "Enthesitis", "Entropion", "Enuresis", "Ependymoma", "Epicanthus", "Epicanthus inversus", "Epidermal acanthosis", "Epidermal hyperkeratosis", "Epidermal nevus", "Epidermoid cyst", "Epigastric pain", "Epileptic encephalopathy", "Epileptic spasm", "Epiphora", "Epiphyseal dysplasia", "Epiphyseal stippling", "Epiretinal membrane", "Episodic ataxia", "Episodic hyperhidrosis", "Episodic hypertension", "Episodic pain", "Episodic respiratory distress", "Episodic tachypnea", "Episodic vomiting", "Epispadias", "Epistaxis", "Equinovarus deformity", "Equinus calcaneus", "Erectile dysfunction", "Erlenmeyer flask deformity of the femurs", "Eruption failure", "Erysipelas", "Erythema", "Erythema nodosum", "Erythematous plaque", "Erythrocyte inclusion bodies", "Erythroderma", "Erythroid hyperplasia", "Erythroid hypoplasia", "Esodeviation", "Esophageal atresia", "Esophageal carcinoma", "Esophageal neoplasm", "Esophageal stenosis", "Esophageal stricture", "Esophageal varix", "Esophagitis", "Ethylmalonic aciduria", "Eunuchoid habitus", "Euryblepharon", "Eversion of lateral third of lower eyelids", "Everted upper lip vermilion", "Exaggerated cupid s bow", "Exaggerated startle response", "Exanthem", "Excessive daytime somnolence", "Excessive salivation", "Excessive wrinkled skin", "Excessive wrinkling of palmar skin", "Exercise induced muscle cramps", "Exercise induced muscle fatigue", "Exercise induced muscle stiffness", "Exercise induced myalgia", "Exercise induced myoglobinuria", "Exercise induced rhabdomyolysis", "Exercise intolerance", "Exertional dyspnea", "Exodeviation", "Exostoses", "Expressive aphasia", "Expressive language delay", "External ear malformation", "External genital hypoplasia", "External ophthalmoplegia", "Extra axial cerebrospinal fluid accumulation", "Extrahepatic cholestasis", "Extramedullary hematopoiesis", "Extrapyramidal dyskinesia", "Extrapyramidal muscular rigidity", "Exudative retinal detachment", "Eyelid coloboma", "Eyelid myoclonus", "Facial asymmetry", "Facial capillary hemangioma", "Facial cleft", "Facial diplegia", "Facial edema", "Facial erythema", "Facial grimacing", "Facial hemangioma", "Facial hyperostosis", "Facial hypertrichosis", "Facial hypotonia", "Facial myokymia", "Facial paralysis", "Facial shape deformation", "Facial telangiectasia", "Failure of eruption of permanent teeth", "Failure to thrive", "Failure to thrive in infancy", "Fair hair", "Falls", "Fasciculations", "Fasting hyperinsulinemia", "Fasting hypoglycemia", "Fat malabsorption", "Fatigable weakness of bulbar muscles", "Fatigable weakness of distal limb muscles", "Fatigable weakness of respiratory muscles", "Fatigable weakness of skeletal muscles", "Fatigable weakness of swallowing muscles", "Fatiguable weakness of proximal limb muscles", "Fatigue", "Fatty replacement of skeletal muscle", "Feeding difficulties", "Feeding difficulties in infancy", "Female external genitalia in individual with 46 xy karyotype", "Female hypogonadism", "Female infertility", "Female reproductive system neoplasm", "Female sexual dysfunction", "Femoral bowing", "Femoral hernia", "Fetal akinesia sequence", "Fetal distress", "Fetal onset", "Fetal polyuria", "Fetal ultrasound soft marker", "Fever", "Fibroadenoma of the breast", "Fibrosarcoma", "Fibrous tissue neoplasm", "Fibular aplasia", "Fibular hypoplasia", "Fine hair", "Finger agnosia", "Finger clinodactyly", "Finger swelling", "Finger syndactyly", "Fingernail dysplasia", "Fingerprint intracellular accumulation of autofluorescent lipopigment storage material", "First degree atrioventricular block", "First dorsal interossei muscle weakness", "Flank pain", "Flared iliac wing", "Flared metaphysis", "Flared nostrils", "Flaring of rib cage", "Flat acetabular roof", "Flat cornea", "Flat face", "Flat forehead", "Flat nasal alae", "Flat occiput", "Flattened epiphysis", "Flattened femoral epiphysis", "Flattened femoral head", "Flexion contracture of digit", "Flexion contracture of thumb", "Fluctuations in consciousness", "Flushing", "Foam cells", "Focal aware seizure", "Focal cortical dysplasia", "Focal cortical dysplasia type ii", "Focal dystonia", "Focal emotional seizure", "Focal impaired awareness seizure", "Focal motor seizure", "Focal myoclonic seizure", "Focal non motor seizure", "Focal onset seizure", "Focal segmental glomerulosclerosis", "Focal t2 hyperintense basal ganglia lesion", "Focal t2 hyperintense brainstem lesion", "Focal tonic seizure", "Focal white matter lesions", "Follicular hyperkeratosis", "Follicular hyperplasia", "Follicular thyroid carcinoma", "Food allergy", "Food intolerance", "Foot acroosteolysis", "Foot dorsiflexor weakness", "Foot oligodactyly", "Fractures of the long bones", "Fragile nails", "Fragile skin", "Fragmented epiphyses", "Freckling", "Frequent falls", "Frontal balding", "Frontal cortical atrophy", "Frontal hirsutism", "Frontal lobe dementia", "Frontotemporal cerebral atrophy", "Frontotemporal dementia", "Full cheeks", "Fulminant hepatic failure", "Functional abnormality of male internal genitalia", "Functional abnormality of the gastrointestinal tract", "Functional abnormality of the inner ear", "Functional abnormality of the middle ear", "Functional intestinal obstruction", "Functional motor deficit", "Furrowed tongue", "Fused cervical vertebrae", "Fusion of the cerebellar hemispheres", "Gait ataxia", "Gait disturbance", "Gait imbalance", "Galactorrhea", "Gangrene", "Gastric ulcer", "Gastritis", "Gastroesophageal reflux", "Gastrointestinal atresia", "Gastrointestinal carcinoma", "Gastrointestinal hemorrhage", "Gastrointestinal infarctions", "Gastrointestinal inflammation", "Gastrointestinal obstruction", "Gastrointestinal stroma tumor", "Gastroparesis", "Gastrostomy tube feeding in infancy", "Gaze evoked nystagmus", "Generalized abnormality of skin", "Generalized aminoaciduria", "Generalized amyotrophy", "Generalized clonic seizure", "Generalized dystonia", "Generalized edema", "Generalized hirsutism", "Generalized hyperkeratosis", "Generalized hyperpigmentation", "Generalized hyperreflexia", "Generalized hypertrichosis", "Generalized hypopigmentation", "Generalized hypopigmentation of hair", "Generalized hypotonia", "Generalized joint laxity", "Generalized limb muscle atrophy", "Generalized lipodystrophy", "Generalized lymphadenopathy", "Generalized muscle weakness", "Generalized myoclonic atonic seizure", "Generalized myoclonic seizure", "Generalized neonatal hypotonia", "Generalized onset motor seizure", "Generalized onset seizure", "Generalized osteoporosis", "Generalized osteosclerosis", "Generalized tonic seizure", "Genetic anticipation", "Genital neoplasm", "Genu recurvatum", "Genu valgum", "Genu varum", "Geographic atrophy", "Germ cell neoplasia", "Germinoma", "Giant platelets", "Giant somatosensory evoked potentials", "Gingival bleeding", "Gingival fibromatosis", "Gingival overgrowth", "Gingival recession", "Gingivitis", "Glaucoma", "Glioblastoma multiforme", "Glioma", "Gliosis", "Global brain atrophy", "Glomerular deposits", "Glomerular sclerosis", "Glomerulonephritis", "Glomerulopathy", "Glomus jugular tumor", "Glossitis", "Glossoptosis", "Glucose intolerance", "Glutaric aciduria", "Glycosuria", "Goiter", "Gonadal dysgenesis", "Gonadal neoplasm", "Gonadoblastoma", "Gonosomal inheritance", "Gout", "Gowers sign", "Grammar specific speech disorder", "Granulocytopenia", "Granulomatosis", "Gray matter heterotopia", "Gynecomastia", "Hallucinations", "Hallux valgus", "Hamartoma", "Hamartoma of the eye", "Hamartoma of tongue", "Hamartomatous polyposis", "Hammertoe", "Hamstring contractures", "Hand apraxia", "Hand clenching", "Hand muscle weakness", "Hand oligodactyly", "Hand polydactyly", "Hand tremor", "Handgrip myotonia", "Happy demeanor", "Head banging", "Head titubation", "Head tremor", "Headache", "Heart block", "Heat intolerance", "Heinz bodies", "Hemangioblastoma", "Hemangiomatosis", "Hematological neoplasm", "Hemianopia", "Hemiatrophy", "Hemifacial spasm", "Hemihypertrophy", "Hemimegalencephaly", "Hemiparesis", "Hemiplegia hemiparesis", "Hemivertebrae", "Hemoglobinuria", "Hemolytic anemia", "Hemoptysis", "Hemorrhage of the eye", "Heparan sulfate excretion in urine", "Hepatic cysts", "Hepatic encephalopathy", "Hepatic failure", "Hepatic fibrosis", "Hepatic necrosis", "Hepatitis", "Hepatoblastoma", "Hepatocellular adenoma", "Hepatocellular carcinoma", "Hepatomegaly", "Hepatosplenomegaly", "Hereditary nonpolyposis colorectal carcinoma", "Hernia", "Herpes simplex encephalitis", "Heterochromia iridis", "Heterogeneous", "Heteronymous hemianopia", "Heterophoria", "Heterotaxy", "Heterotropia", "Hiatus hernia", "High anterior hairline", "High forehead", "High frequency hearing impairment", "High frequency sensorineural hearing impairment", "High hypermetropia", "High myopia", "High narrow palate", "High palate", "High pitched voice", "Highly arched eyebrow", "Hip contracture", "Hip dislocation", "Hip dysplasia", "Hip flexor weakness", "Hip osteoarthritis", "Hip pain", "Hip subluxation", "Hirsutism", "Hoarse cry", "Hoarse voice", "Hodgkin lymphoma", "Holoprosencephaly", "Homocystinuria", "Honeycomb lung", "Horizontal eyebrow", "Horizontal nystagmus", "Horizontal pendular nystagmus", "Horizontal ribs", "Horseshoe kidney", "Humeroradial synostosis", "Hydranencephaly", "Hydrocele testis", "Hydrocephalus", "Hydrops fetalis", "Hydroureter", "Hydroxyprolinuria", "Hyperactive deep tendon reflexes", "Hyperactive patellar reflex", "Hyperactivity", "Hyperacusis", "Hyperaldosteronism", "Hyperammonemia", "Hyperautofluorescent retinal lesion", "Hypercalcemia", "Hyperchloremic acidosis", "Hypercholesterolemia", "Hypercoagulability", "Hyperconvex fingernails", "Hyperconvex nail", "Hyperesthesia", "Hyperextensibility at wrists", "Hyperextensibility of the finger joints", "Hyperextensibility of the knee", "Hyperextensible skin", "Hypergalactosemia", "Hyperglycemia", "Hypergonadotropic hypogonadism", "Hypergranulosis", "Hyperhidrosis", "Hyperhomocystinemia", "Hyperinsulinemic hypoglycemia", "Hyperintensity of cerebral white matter on mri", "Hyperkalemia", "Hyperkeratosis", "Hyperketonemia", "Hyperkinetic movements", "Hyperlipidemia", "Hyperlipoproteinemia", "Hyperlordosis", "Hypermagnesemia", "Hypermethioninemia", "Hypermetric saccades", "Hypermetropia", "Hypernatriuria", "Hyperorality", "Hyperostosis", "Hyperoxaluria", "Hyperparathyroidism", "Hyperphenylalaninemia", "Hyperphosphatemia", "Hyperphosphaturia", "Hyperpigmentation in sun exposed areas", "Hyperpigmentation of the skin", "Hyperpituitarism", "Hyperplasia of the maxilla", "Hyperreflexia", "Hyperreflexia in upper limbs", "Hypersomnia", "Hypersplenism", "Hypertelorism", "Hypertension associated with pheochromocytoma", "Hypertensive crisis", "Hyperthyroidism", "Hypertonia", "Hypertrichosis", "Hypertriglyceridemia", "Hypertrophic cardiomyopathy", "Hypertrophic nerve changes", "Hyperuricemia", "Hyperuricosuria", "Hyperventilation", "Hypoamylasemia", "Hypocalcemia", "Hypocalcemic seizures", "Hypocalcemic tetany", "Hypocalciuria", "Hypochloremia", "Hypocholesterolemia", "Hypochromia", "Hypochromic anemia", "Hypochromic microcytic anemia", "Hypodontia", "Hypoglycemic coma", "Hypoglycemic seizures", "Hypogonadism", "Hypogonadotropic hypogonadism", "Hypohidrosis", "Hypointensity of cerebral white matter on mri", "Hypokalemia", "Hypokalemic alkalosis", "Hypokalemic metabolic alkalosis", "Hypoketotic hypoglycemia", "Hypokinesia", "Hypolipidemia", "Hypolipoproteinemia", "Hypomethioninemia", "Hypometric saccades", "Hypomimic face", "Hypoparathyroidism", "Hypophosphatemia", "Hypophosphatemic rickets", "Hypopigmentation of the fundus", "Hypopigmentation of the skin", "Hypopigmented macule", "Hypopigmented skin patches", "Hypopituitarism", "Hypoplasia of olfactory tract", "Hypoplasia of penis", "Hypoplasia of teeth", "Hypoplasia of the brainstem", "Hypoplasia of the corpus callosum", "Hypoplasia of the ear cartilage", "Hypoplasia of the epiglottis", "Hypoplasia of the femoral head", "Hypoplasia of the fovea", "Hypoplasia of the frontal lobes", "Hypoplasia of the iris", "Hypoplasia of the musculature", "Hypoplasia of the odontoid process", "Hypoplasia of the olfactory bulb", "Hypoplasia of the pons", "Hypoplasia of the radius", "Hypoplasia of the uterus", "Hypoplasia of the vagina", "Hypoplasia of the ventral pons", "Hypoplastic anemia", "Hypoplastic aortic arch", "Hypoplastic cervical vertebrae", "Hypoplastic dermoepidermal hemidesmosomes", "Hypoplastic facial bones", "Hypoplastic female external genitalia", "Hypoplastic fifth fingernail", "Hypoplastic fifth toenail", "Hypoplastic fingernail", "Hypoplastic frontal sinuses", "Hypoplastic heart", "Hypoplastic helices", "Hypoplastic hippocampus", "Hypoplastic ilia", "Hypoplastic labia majora", "Hypoplastic labia minora", "Hypoplastic nipples", "Hypoplastic pelvis", "Hypoplastic pubic rami", "Hypoplastic toenails", "Hypoplastic vertebral bodies", "Hypoproteinemia", "Hyporeflexia", "Hyporeflexia of lower limbs", "Hyporeflexia of upper limbs", "Hyposmia", "Hypotelorism", "Hypotension", "Hypothalamic gonadotropin releasing hormone deficiency", "Hypothalamic hamartoma", "Hypothalamic hypothyroidism", "Hypothermia", "Hypotriglyceridemia", "Hypouricemia", "Hypoventilation", "Hypovolemic shock", "Hypsarrhythmia", "Ichthyosis", "Ileus", "Immotile sperm", "Immune dysregulation", "Immunodeficiency", "Immunologic hypersensitivity", "Impacted tooth", "Impaired adp induced platelet aggregation", "Impaired antigen specific response", "Impaired collagen induced platelet aggregation", "Impaired distal proprioception", "Impaired distal tactile sensation", "Impaired distal vibration sensation", "Impaired epinephrine induced platelet aggregation", "Impaired glucose tolerance", "Impaired horizontal smooth pursuit", "Impaired mastication", "Impaired neutrophil bactericidal activity", "Impaired oropharyngeal swallow response", "Impaired pain sensation", "Impaired proprioception", "Impaired smooth pursuit", "Impaired social interactions", "Impaired t cell function", "Impaired tactile sensation", "Impaired tandem gait", "Impaired temperature sensation", "Impaired use of nonverbal behaviors", "Impaired vibration sensation at ankles", "Impaired vibration sensation in the lower limbs", "Impaired vibratory sensation", "Impaired visuospatial constructive cognition", "Impairment in personality functioning", "Impairment of activities of daily living", "Impotence", "Inability to walk", "Inappropriate antidiuretic hormone secretion", "Inappropriate behavior", "Inappropriate crying", "Inappropriate laughter", "Inappropriate sexual behavior", "Incisor macrodontia", "Incomitant strabismus", "Incomplete partition of the cochlea type ii", "Incomplete penetrance", "Incoordination", "Increased adipose tissue", "Increased arm span", "Increased b cell count", "Increased blood pressure", "Increased blood urea nitrogen", "Increased body mass index", "Increased body weight", "Increased bone mineral density", "Increased c peptide level", "Increased cerebral lipofuscin", "Increased circulating acth level", "Increased circulating androgen concentration", "Increased circulating antibody level", "Increased circulating cortisol level", "Increased circulating gonadotropin level", "Increased circulating iga level", "Increased circulating igg level", "Increased circulating igm level", "Increased circulating lactate dehydrogenase concentration", "Increased circulating prolactin concentration", "Increased circulating renin level", "Increased connective tissue", "Increased csf lactate", "Increased density of long bones", "Increased endomysial connective tissue", "Increased fecal porphyrin", "Increased female libido", "Increased head circumference", "Increased hepatic glycogen content", "Increased hepatocellular lipid droplets", "Increased intracranial pressure", "Increased intramyocellular lipid droplets", "Increased laxity of ankles", "Increased ldl cholesterol concentration", "Increased level of hippuric acid in urine", "Increased level of l fucose in urine", "Increased mean corpuscular hemoglobin concentration", "Increased mean corpuscular volume", "Increased megakaryocyte count", "Increased muscle fatiguability", "Increased muscle glycogen content", "Increased muscle lipid content", "Increased nuchal translucency", "Increased overbite", "Increased proportion of cd25 mast cells", "Increased proteinogenic amino acid level in urine", "Increased sensitivity to ionizing radiation", "Increased serine family amino acid in urine", "Increased serum iron", "Increased serum lactate", "Increased serum pyruvate", "Increased serum serotonin", "Increased serum testosterone level", "Increased skull ossification", "Increased sulfur amino acid level in urine", "Increased susceptibility to fractures", "Increased theta frequency activity in eeg", "Increased total bilirubin", "Increased urinary cortisol level", "Increased urinary non proteinogenic amino acid level", "Increased urine alpha ketoglutarate concentration", "Increased urine proteinogenic amino acid derivative level", "Increased vertebral height", "Ineffective esophageal peristalsis", "Infantile axial hypotonia", "Infantile encephalopathy", "Infantile muscular hypotonia", "Infantile onset", "Infantile spasms", "Infection related seizure", "Infectious encephalitis", "Inferior lens subluxation", "Inferior vermis hypoplasia", "Infertility", "Inflammation of the large intestine", "Inflammatory abnormality of the eye", "Inflexible adherence to routines or rituals", "Inguinal hernia", "Insidious onset", "Insomnia", "Inspiratory stridor", "Insulin resistance", "Insulin resistant diabetes mellitus", "Intellectual disability borderline", "Intellectual disability mild", "Intellectual disability moderate", "Intellectual disability profound", "Intellectual disability progressive", "Intellectual disability severe", "Intercostal muscle weakness", "Interictal eeg abnormality", "Intermittent diarrhea", "Intermittent episodes of respiratory insufficiency due to muscle weakness", "Internally nucleated skeletal muscle fibers", "Interrupted aortic arch", "Interstitial cardiac fibrosis", "Interstitial pneumonitis", "Intestinal atresia", "Intestinal fistula", "Intestinal hypoplasia", "Intestinal malrotation", "Intestinal polyp", "Intestinal pseudo obstruction", "Intraalveolar phospholipid accumulation", "Intracellular accumulation of autofluorescent lipopigment storage material", "Intracranial hemorrhage", "Intracranial meningioma", "Intractable diarrhea", "Intrauterine growth retardation", "Intrinsic hand muscle atrophy", "Intussusception", "Inverted nipples", "Involuntary movements", "Iridocyclitis", "Iris atrophy", "Iris coloboma", "Iris hypopigmentation", "Iron accumulation in brain", "Iron accumulation in globus pallidus", "Iron deficiency anemia", "Irregular epiphyses", "Irregular femoral epiphysis", "Irregular hyperpigmentation", "Irregular menstruation", "Irregular vertebral endplates", "Irritability", "Ischemic stroke", "J shaped sella turcica", "Jaundice", "Jerky head movements", "Jerky ocular pursuit movements", "Joint contracture of the hand", "Joint contractures involving the joints of the feet", "Joint dislocation", "Joint hemorrhage", "Joint hyperflexibility", "Joint hypermobility", "Joint laxity", "Joint stiffness", "Joint subluxation", "Joint swelling", "Juvenile aseptic necrosis", "Juvenile cataract", "Juvenile myelomonocytic leukemia", "Juvenile onset", "Juvenile rheumatoid arthritis", "Keloids", "Keratitis", "Keratoconjunctivitis", "Keratosis pilaris", "Ketoacidosis", "Ketonuria", "Ketosis", "Ketotic hypoglycemia", "Kinetic tremor", "Knee clonus", "Knee dislocation", "Knee flexion contracture", "Kyphoscoliosis", "Kyphosis", "Labial hypertrophy", "Lack of insight", "Lack of peer relationships", "Lack of skin elasticity", "Lack of t cell function", "Lacrimal duct atresia", "Lacrimal duct stenosis", "Lacrimation abnormality", "Lactic acidosis", "Lacticaciduria", "Lactose intolerance", "Lagopthalmos", "Lambdoidal craniosynostosis", "Language impairment", "Large basal ganglia", "Large beaked nose", "Large earlobe", "Large face", "Large fleshy ears", "Large for gestational age", "Large foramen magnum", "Large forehead", "Large hands", "Large intestinal polyposis", "Large placenta", "Large sella turcica", "Laryngeal cleft", "Laryngeal dystonia", "Laryngeal hypoplasia", "Laryngeal stenosis", "Laryngeal stridor", "Laryngomalacia", "Laryngotracheomalacia", "Late onset", "Lateral clavicle hook", "Leber optic atrophy", "Left atrial enlargement", "Left to right shunt", "Left ventricular hypertrophy", "Left ventricular noncompaction cardiomyopathy", "Left ventricular outflow tract obstruction", "Left ventricular systolic dysfunction", "Leg muscle stiffness", "Leiomyosarcoma", "Lens subluxation", "Lethal skeletal dysplasia", "Lethargy", "Leukemia", "Leukocytosis", "Leukodystrophy", "Leukoencephalopathy", "Leukonychia", "Leukopenia", "Lewy bodies", "Leydig cell neoplasia", "Lichenification", "Limb ataxia", "Limb dystonia", "Limb fasciculations", "Limb girdle muscle atrophy", "Limb girdle muscle weakness", "Limb girdle muscular dystrophy", "Limb hypertonia", "Limb joint contracture", "Limb muscle weakness", "Limb myoclonus", "Limb pain", "Limb tremor", "Limb undergrowth", "Limitation of joint mobility", "Limitation of knee mobility", "Limitation of movement at ankles", "Limitation of neck motion", "Limited elbow extension", "Limited elbow movement", "Limited extraocular movements", "Limited hip extension", "Limited hip movement", "Limited knee extension", "Limited wrist movement", "Lipid accumulation in hepatocytes", "Lipoatrophy", "Lipodystrophy", "Lipoma", "Lissencephaly", "Liver abscess", "Lobulated tongue", "Localized hirsutism", "Localized osteoporosis", "Localized skin lesion", "Long clavicles", "Long ear", "Long eyelashes", "Long fingers", "Long foot", "Long hallux", "Long neck", "Long nose", "Long palm", "Long palpebral fissure", "Long penis", "Long philtrum", "Long toe", "Long tract signs", "Lop ear", "Loss of ability to walk", "Loss of consciousness", "Loss of eyelashes", "Loss of purkinje cells in the cerebellar vermis", "Loss of speech", "Loss of subcutaneous adipose tissue in limbs", "Loss of voice", "Low alkaline phosphatase", "Low anterior hairline", "Low apgar score", "Low back pain", "Low frustration tolerance", "Low grade fever", "Low hanging columella", "Low levels of vitamin d", "Low molecular weight proteinuria", "Low plasma citrulline", "Low posterior hairline", "Low set nipples", "Low set posteriorly rotated ears", "Lower extremity joint dislocation", "Lower eyelid coloboma", "Lower limb amyotrophy", "Lower limb asymmetry", "Lower limb hyperreflexia", "Lower limb hypertonia", "Lower limb metaphyseal irregularity", "Lower limb muscle weakness", "Lower limb pain", "Lower limb spasticity", "Lower limb undergrowth", "Lumbar hyperlordosis", "Lumbar kyphosis", "Lumbar scoliosis", "Lung adenocarcinoma", "Lymphadenitis", "Lymphangiectasis", "Lymphangioma", "Lymphedema", "Lymphocytosis", "Lymphoma", "Lymphopenia", "Lymphoproliferative disorder", "Macrocephaly at birth", "Macrocytic anemia", "Macrodactyly", "Macrodontia", "Macrodontia of permanent maxillary central incisor", "Macroglossia", "Macrogyria", "Macroorchidism", "Macroscopic hematuria", "Macrotia", "Macrovesicular hepatic steatosis", "Macular atrophy", "Macular coloboma", "Macular degeneration", "Macular hyperpigmentation", "Macular purpura", "Macular thickening", "Macule", "Malabsorption", "Malar prominence", "Male hypogonadism", "Male infertility", "Male pseudohermaphroditism", "Male reproductive system neoplasm", "Male sexual dysfunction", "Malignant genitourinary tract tumor", "Malignant hyperthermia", "Malignant neoplasm of the central nervous system", "Malnutrition", "Malrotation of small bowel", "Mandibular aplasia", "Mandibular prognathia", "Mania", "Mask like facies", "Mastoiditis", "Maternal diabetes", "Maternal hypertension", "Maturity onset diabetes of the young", "Meconium stained amniotic fluid", "Medial flaring of the eyebrow", "Median cleft lip", "Median cleft palate", "Mediastinal lymphadenopathy", "Medullary nephrocalcinosis", "Medulloblastoma", "Megalencephaly", "Megaloblastic anemia", "Megalocornea", "Melanocytic nevus", "Melanoma", "Melena", "Membranoproliferative glomerulonephritis", "Memory impairment", "Meningioma", "Meningitis", "Meningocele", "Menorrhagia", "Mental deterioration", "Mesoaxial polydactyly", "Mesomelia", "Metabolic acidosis", "Metabolic alkalosis", "Metacarpophalangeal joint contracture", "Metamorphopsia", "Metaphyseal chondrodysplasia", "Metaphyseal cupping", "Metaphyseal dysplasia", "Metaphyseal irregularity", "Metaphyseal sclerosis", "Metaphyseal spurs", "Metaphyseal striations", "Metaphyseal widening", "Metatarsal synostosis", "Metatarsus adductus", "Metatarsus valgus", "Methemoglobinemia", "Methylmalonic acidemia", "Methylmalonic aciduria", "Metopic synostosis", "Metrorrhagia", "Microcornea", "Microcytic anemia", "Microdontia", "Microglossia", "Micrographia", "Micromelia", "Micronodular cirrhosis", "Micropenis", "Microphallus", "Microretrognathia", "Microscopic hematuria", "Microtia third degree", "Microvesicular hepatic steatosis", "Middle age onset", "Midface retrusion", "Midline defect of the nose", "Migraine", "Mild global developmental delay", "Mild hearing impairment", "Mild microcephaly", "Mild postnatal growth retardation", "Mild short stature", "Mildly elevated creatine kinase", "Milia", "Minicore myopathy", "Minimal change glomerulonephritis", "Misalignment of incisors", "Missing ribs", "Mitochondrial inheritance", "Mitochondrial myopathy", "Mitochondrial respiratory chain defects", "Mitral stenosis", "Mitral valve calcification", "Mitral valve prolapse", "Mitten deformity", "Mixed demyelinating and axonal polyneuropathy", "Mixed hearing impairment", "Mixed hypo and hyperpigmentation of the skin", "Moderate albuminuria", "Moderate global developmental delay", "Moderate sensorineural hearing impairment", "Moderately reduced visual acuity", "Molar tooth sign on mri", "Molluscoid pseudotumors", "Molluscum contagiosum", "Monochromacy", "Monocytosis", "Monotonic speech", "Mood swings", "Morning glory anomaly", "Morning myoclonic jerks", "Morphological abnormality of the corticospinal tract", "Morphological abnormality of the middle ear", "Morphological abnormality of the pyramidal tract", "Morphological abnormality of the vestibule of the inner ear", "Mortality aging", "Motor axonal neuropathy", "Motor delay", "Motor deterioration", "Motor neuron atrophy", "Motor polyneuropathy", "Motor regression", "Motor seizure", "Mottled pigmentation", "Movement abnormality of the tongue", "Moyamoya phenomenon", "Mucosal telangiectasiae", "Multicystic kidney dysplasia", "Multifactorial inheritance", "Multifocal cerebral white matter abnormalities", "Multifocal epileptiform discharges", "Multifocal seizures", "Multiple cafe au lait spots", "Multiple enchondromatosis", "Multiple epiphyseal dysplasia", "Multiple exostoses", "Multiple gastric polyps", "Multiple glomerular cysts", "Multiple impacted teeth", "Multiple joint contractures", "Multiple joint dislocation", "Multiple lentigines", "Multiple lipomas", "Multiple mitochondrial dna deletions", "Multiple myeloma", "Multiple prenatal fractures", "Multiple renal cysts", "Multiple rib fractures", "Multiple rows of eyelashes", "Multiple suture craniosynostosis", "Muscle abnormality related to mitochondrial dysfunction", "Muscle fiber atrophy", "Muscle fiber inclusion bodies", "Muscle fiber necrosis", "Muscle fiber splitting", "Muscle fiber tubular inclusions", "Muscle fibrillation", "Muscle flaccidity", "Muscle hypertrophy of the lower extremities", "Muscle spasm", "Muscle stiffness", "Muscle weakness", "Muscular dystrophy", "Muscular hypotonia of the trunk", "Muscular ventricular septal defect", "Mutism", "Myalgia", "Mydriasis", "Myelodysplasia", "Myelofibrosis", "Myeloid leukemia", "Myelomeningocele", "Myelopathy", "Myeloproliferative disorder", "Myocardial fibrosis", "Myoclonic seizure", "Myoclonic spasms", "Myoclonus", "Myofibrillar myopathy", "Myoglobinuria", "Myokymia", "Myopathic facies", "Myopathy", "Myopia", "Myositis", "Myotonia", "Naevus flammeus of the eyelid", "Nail dysplasia", "Nail dystrophy", "Nail pits", "Narrow face", "Narrow foot", "Narrow foramen obturatorium", "Narrow forehead", "Narrow iliac wing", "Narrow internal auditory canal", "Narrow jaw", "Narrow mouth", "Narrow nasal bridge", "Narrow nasal ridge", "Narrow nose", "Narrow palate", "Narrow palm", "Narrow palpebral fissure", "Narrow pelvis bone", "Narrow vertebral interpedicular distance", "Nasal congestion", "Nasal regurgitation", "Nasal speech", "Nasogastric tube feeding", "Nasogastric tube feeding in infancy", "Nasolacrimal duct obstruction", "Natal tooth", "Nausea", "Nausea and vomiting", "Neck flexor weakness", "Neck muscle weakness", "Negativism", "Nemaline bodies", "Neonatal alloimmune thrombocytopenia", "Neonatal asphyxia", "Neonatal breathing dysregulation", "Neonatal death", "Neonatal hyperbilirubinemia", "Neonatal hypoglycemia", "Neonatal hypotonia", "Neonatal insulin dependent diabetes mellitus", "Neonatal onset", "Neonatal respiratory distress", "Neoplasm", "Neoplasm by histology", "Neoplasm of fatty tissue", "Neoplasm of head and neck", "Neoplasm of striated muscle", "Neoplasm of the adrenal cortex", "Neoplasm of the adrenal gland", "Neoplasm of the breast", "Neoplasm of the colon", "Neoplasm of the ear", "Neoplasm of the endocrine system", "Neoplasm of the eye", "Neoplasm of the gallbladder", "Neoplasm of the gastrointestinal tract", "Neoplasm of the genitourinary tract", "Neoplasm of the heart", "Neoplasm of the inner ear", "Neoplasm of the large intestine", "Neoplasm of the larynx", "Neoplasm of the liver", "Neoplasm of the male external genitalia", "Neoplasm of the nervous system", "Neoplasm of the oral cavity", "Neoplasm of the pancreas", "Neoplasm of the parathyroid gland", "Neoplasm of the peripheral nervous system", "Neoplasm of the pituitary gland", "Neoplasm of the rectum", "Neoplasm of the respiratory system", "Neoplasm of the skeletal system", "Neoplasm of the skin", "Neoplasm of the small intestine", "Neoplasm of the stomach", "Neoplasm of the thyroid gland", "Neoplasm of the tongue", "Neoplasm of the tracheobronchial system", "Nephritis", "Nephrocalcinosis", "Nephrogenic diabetes insipidus", "Nephrolithiasis", "Nephronophthisis", "Nephropathy", "Nephrotic syndrome", "Neuralgia", "Neurodegeneration", "Neuroendocrine neoplasm", "Neurofibrillary tangles", "Neurofibromas", "Neurogenic bladder", "Neuroinflammation", "Neuromuscular dysphagia", "Neuronal loss in basal ganglia", "Neuronal loss in central nervous system", "Neuronal loss in the cerebral cortex", "Neuropathic arthropathy", "Neutropenia in presence of anti neutropil antibodies", "Neutrophilia", "Nevus", "Night sweats", "No social interaction", "Nocturia", "Nocturnal hypoventilation", "Nocturnal seizures", "Nodular goiter", "Non hodgkin lymphoma", "Non medullary thyroid carcinoma", "Non midline cleft lip", "Non midline cleft palate", "Non motor seizure", "Non obstructive azoospermia", "Noncompaction cardiomyopathy", "Nonimmune hydrops fetalis", "Nonketotic hypoglycemia", "Nonprogressive", "Nonprogressive cerebellar ataxia", "Nonprogressive encephalopathy", "Nonspherocytic hemolytic anemia", "Normochromic anemia", "Normocytic anemia", "Nuclear cataract", "Numerous nevi", "Numerous pigmented freckles", "Nyctalopia", "Nystagmus induced head nodding", "Obsessive compulsive behavior", "Obsessive compulsive trait", "Obstructive sleep apnea", "Occipital cortical atrophy", "Occipital encephalocele", "Occipital meningocele", "Ocular albinism", "Ocular anterior segment dysgenesis", "Ocular pain", "Oculogyric crisis", "Oculomotor apraxia", "Oculomotor nerve palsy", "Odontogenic neoplasm", "Oligoarthritis", "Oligodactyly", "Oligodontia", "Oligohydramnios", "Oligomenorrhea", "Oligosacchariduria", "Oligospermia", "Oliguria", "Olivopontocerebellar atrophy", "Olivopontocerebellar hypoplasia", "Omphalocele", "Onion bulb formation", "Onset", "Onychogryposis", "Onychogryposis of toenails", "Onycholysis", "Onychomycosis", "Open angle glaucoma", "Open bite", "Open mouth", "Open operculum", "Ophthalmoparesis", "Opisthotonus", "Opportunistic infection", "Opsoclonus", "Optic atrophy", "Optic disc coloboma", "Optic disc hypoplasia", "Optic disc pallor", "Optic nerve compression", "Optic nerve dysplasia", "Optic nerve hypoplasia", "Optic neuropathy", "Oral aversion", "Oral cavity bleeding", "Oral cleft", "Oral leukoplakia", "Oral mucosal blisters", "Oral pharyngeal dysphagia", "Oral ulcer", "Orchitis", "Organic aciduria", "Orofacial dyskinesia", "Oromandibular dystonia", "Oromotor apraxia", "Oroticaciduria", "Orthopnea", "Orthostatic hypotension", "Orthostatic hypotension due to autonomic dysfunction", "Osteoarthritis", "Osteochondroma", "Osteochondrosis", "Osteolysis", "Osteolysis involving bones of the feet", "Osteolysis involving bones of the upper limbs", "Osteolytic defects of the distal phalanges of the hand", "Osteomalacia", "Osteomyelitis", "Osteopenia", "Osteopetrosis", "Osteoporosis", "Osteosarcoma", "Otitis media", "Otosclerosis", "Oval face", "Ovarian carcinoma", "Ovarian cyst", "Ovarian gonadoblastoma", "Ovarian neoplasm", "Ovarian papillary adenocarcinoma", "Overfolding of the superior helices", "Overfriendliness", "Overgrowth", "Overlapping fingers", "Overlapping toe", "Overriding aorta", "Overtubulated long bones", "Overweight", "Ovoid vertebral bodies", "Ovotestis", "Oxycephaly", "Pace of progression", "Pain", "Pain in head and neck region", "Pain insensitivity", "Pallor", "Palmar hyperhidrosis", "Palmar pits", "Palmar telangiectasia", "Palmoplantar blistering", "Palmoplantar cutis laxa", "Palmoplantar hyperhidrosis", "Palpebral edema", "Palpitations", "Pancreatic adenocarcinoma", "Pancreatic cysts", "Pancreatic fibrosis", "Pancreatic hypoplasia", "Pancreatic islet cell hyperplasia", "Pancreatitis", "Pancytopenia", "Panhypogammaglobulinemia", "Panhypopituitarism", "Panniculitis", "Papillary renal cell carcinoma", "Papillary thyroid carcinoma", "Papilledema", "Papilloma", "Papule", "Paracentral scotoma", "Paraganglioma", "Parakeratosis", "Paralysis", "Paranoia", "Paraparesis", "Paraplegia", "Paraplegia paraparesis", "Parasomnia", "Parathyroid adenoma", "Parathyroid carcinoma", "Paresthesia", "Parietal bossing", "Parietal cortical atrophy", "Parietal foramina", "Parkinsonism", "Parkinsonism with favorable response to dopaminergic medication", "Paronychia", "Paroxysmal bursts of laughter", "Paroxysmal dystonia", "Paroxysmal involuntary eye movements", "Paroxysmal ventricular tachycardia", "Partial absence of thumb", "Partial agenesis of the corpus callosum", "Partial anomalous pulmonary venous return", "Partial duplication of the distal phalanges of the hand", "Partial duplication of the phalanx of hand", "Patchy alopecia", "Patchy changes of bone mineral density", "Patchy hypopigmentation of hair", "Patchy palmoplantar hyperkeratosis", "Patellar aplasia", "Patellar dislocation", "Patellar hypoplasia", "Patellar subluxation", "Patent ductus arteriosus", "Patent foramen ovale", "Pathologic fracture", "Pectus carinatum", "Pectus excavatum", "Pectus excavatum of inferior sternum", "Pedal edema", "Pediatric onset", "Pelvic girdle muscle weakness", "Pelvic kidney", "Pendular nystagmus", "Penetrating foot ulcers", "Peptic ulcer", "Periauricular skin pits", "Pericardial effusion", "Pericarditis", "Perifoveal ring of hyperautofluorescence", "Perimembranous ventricular septal defect", "Periodic paralysis", "Periodontitis", "Periorbital edema", "Periorbital fullness", "Peripheral arterial stenosis", "Peripheral axonal degeneration", "Peripheral axonal neuropathy", "Peripheral cyanosis", "Peripheral demyelination", "Peripheral edema", "Peripheral hypermyelination", "Peripheral hypomyelination", "Peripheral neuropathy", "Peripheral opacification of the cornea", "Peripheral pulmonary artery stenosis", "Peripheral retinal avascularization", "Peripheral visual field loss", "Periportal fibrosis", "Perisylvian polymicrogyria", "Peritoneal abscess", "Peritonitis", "Periventricular cysts", "Periventricular heterotopia", "Periventricular leukomalacia", "Periventricular nodular heterotopia", "Periventricular white matter hyperintensities", "Peroneal muscle atrophy", "Perseveration", "Persistence of hemoglobin f", "Persistence of primary teeth", "Persistent ebv viremia", "Persistent head lag", "Personality changes", "Pes cavus", "Pes planus", "Pes valgus", "Petechiae", "Peters anomaly", "Pharyngitis", "Phenotypic variability", "Pheochromocytoma", "Phimosis", "Phocomelia", "Phonophobia", "Photophobia", "Photopsia", "Photoreceptor layer loss on macular oct", "Phthisis bulbi", "Physical urticaria", "Pierre robin sequence", "Pigmentary retinopathy", "Pili canaliculi", "Pili torti", "Pilomatrixoma", "Pineal cyst", "Pituitary adenoma", "Pituitary growth hormone cell adenoma", "Pituitary hypothyroidism", "Pituitary prolactin cell adenoma", "Plagiocephaly", "Plantar hyperkeratosis", "Platybasia", "Platyspondyly", "Pleural effusion", "Pleuritis", "Pneumonia", "Pneumothorax", "Poikilocytosis", "Poikiloderma", "Pointed chin", "Polar cataract", "Pollakisuria", "Polyarticular arthropathy", "Polycystic kidney dysplasia", "Polycystic liver disease", "Polycythemia", "Polydactyly", "Polygenic inheritance", "Polyhydramnios", "Polymicrogyria", "Polyneuropathy", "Polyphagia", "Polysplenia", "Polyuria", "Pontocerebellar atrophy", "Poor appetite", "Poor coordination", "Poor eye contact", "Poor fine motor coordination", "Poor gross motor coordination", "Poor head control", "Poor motor coordination", "Poor speech", "Poor suck", "Poor wound healing", "Popliteal pterygium", "Porencephalic cyst", "Porokeratosis", "Porphyrinuria", "Portal fibrosis", "Portal vein thrombosis", "Positional foot deformity", "Positive romberg sign", "Post partum hemorrhage", "Postaxial foot polydactyly", "Postaxial hand polydactyly", "Postaxial polydactyly", "Posterior blepharitis", "Posterior embryotoxon", "Posterior fossa cyst", "Posterior pharyngeal cleft", "Posterior pituitary dysgenesis", "Posterior polar cataract", "Posterior subcapsular cataract", "Posteriorly rotated ears", "Postexertional malaise", "Postnatal growth retardation", "Postural instability", "Postural tremor", "Potter facies", "Preauricular skin tag", "Preaxial foot polydactyly", "Preaxial hand polydactyly", "Preaxial polydactyly", "Precocious atherosclerosis", "Predominantly lower limb lymphedema", "Prelingual sensorineural hearing impairment", "Premature adrenarche", "Premature arteriosclerosis", "Premature birth", "Premature coronary artery atherosclerosis", "Premature graying of hair", "Premature loss of primary teeth", "Premature loss of teeth", "Premature osteoarthritis", "Premature ovarian insufficiency", "Premature pubarche", "Premature rupture of membranes", "Premature skin wrinkling", "Premature thelarche", "Premature ventricular contraction", "Prematurely aged appearance", "Prenatal maternal abnormality", "Prenatal movement abnormality", "Primary adrenal insufficiency", "Primary amenorrhea", "Primary congenital glaucoma", "Primary gonadal insufficiency", "Primary hypercortisolism", "Primary hyperparathyroidism", "Primary microcephaly", "Primary peritoneal carcinoma", "Primitive neuroectodermal tumor", "Primitive reflex", "Productive cough", "Profound global developmental delay", "Profound hearing impairment", "Profound sensorineural hearing impairment", "Progeroid facial appearance", "Progressive", "Progressive cerebellar ataxia", "Progressive distal muscle weakness", "Progressive encephalopathy", "Progressive external ophthalmoplegia", "Progressive extrapyramidal movement disorder", "Progressive flexion contractures", "Progressive gait ataxia", "Progressive hearing impairment", "Progressive inability to walk", "Progressive leukoencephalopathy", "Progressive macrocephaly", "Progressive microcephaly", "Progressive muscle weakness", "Progressive neurologic deterioration", "Progressive night blindness", "Progressive peripheral neuropathy", "Progressive pes cavus", "Progressive proximal muscle weakness", "Progressive psychomotor deterioration", "Progressive pulmonary function impairment", "Progressive sensorineural hearing impairment", "Progressive spastic paraparesis", "Progressive spastic paraplegia", "Progressive spastic quadriplegia", "Progressive spasticity", "Progressive visual field defects", "Progressive visual loss", "Prolonged bleeding after dental extraction", "Prolonged bleeding after surgery", "Prolonged bleeding following circumcision", "Prolonged bleeding following procedure", "Prolonged bleeding time", "Prolonged neonatal jaundice", "Prolonged partial thromboplastin time", "Prolonged qtc interval", "Prominent antihelix", "Prominent antitragus", "Prominent coccyx", "Prominent crus of helix", "Prominent digit pad", "Prominent ear helix", "Prominent eyelashes", "Prominent forehead", "Prominent metopic ridge", "Prominent nasal bridge", "Prominent nasal tip", "Prominent nasolabial fold", "Prominent nose", "Prominent occiput", "Prominent sternum", "Prominent superficial blood vessels", "Prominent supraorbital ridges", "Prominent umbilicus", "Prominent veins on trunk", "Proportionate short stature", "Proportionate tall stature", "Proptosis", "Prostate neoplasm", "Protein avoidance", "Protein losing enteropathy", "Protruding ear", "Protruding tongue", "Protrusio acetabuli", "Protuberant abdomen", "Proximal amyotrophy", "Proximal femoral epiphysiolysis", "Proximal femoral metaphyseal abnormality", "Proximal femoral metaphyseal irregularity", "Proximal muscle weakness", "Proximal muscle weakness in lower limbs", "Proximal muscle weakness in upper limbs", "Proximal renal tubular acidosis", "Proximal symphalangism", "Proximal tubulopathy", "Proximal upper limb amyotrophy", "Pruritus", "Pseudoarthrosis", "Pseudobulbar paralysis", "Pseudobulbar signs", "Pseudoepiphyses", "Pseudoepiphyses of hand bones", "Pseudoepiphyses of the metacarpals", "Pseudohypoaldosteronism", "Pseudohypoparathyroidism", "Psoriasiform dermatitis", "Psychogenic non epileptic seizure", "Psychomotor deterioration", "Psychomotor retardation", "Psychosis", "Psychotic episodes", "Psychotic mentation", "Pterygium", "Ptosis", "Puberty and gonadal disorders", "Pulmonary artery dilatation", "Pulmonary artery stenosis", "Pulmonary carcinoid tumor", "Pulmonary cyst", "Pulmonary edema", "Pulmonary embolism", "Pulmonary fibrosis", "Pulmonary hemorrhage", "Pulmonary hypoplasia", "Pulmonary infiltrates", "Pulmonary insufficiency", "Pulmonary interstitial high resolution computed tomography abnormality", "Pulmonary venous hypertension", "Pulmonic stenosis", "Pulverulent cataract", "Punctate cataract", "Pure red cell aplasia", "Purpura", "Pustule", "Pyelonephritis", "Pyoderma gangrenosum", "Pyridoxine responsive sideroblastic anemia", "Quadriceps muscle weakness", "Radial bowing", "Radial deviation of the 2nd finger", "Radial deviation of the hand", "Radial deviation of the hand or of fingers of the hand", "Radioulnar dislocation", "Radioulnar synostosis", "Ragged red muscle fibers", "Rapidly progressive", "Raynaud phenomenon", "Reactive hypoglycemia", "Receptive language delay", "Rectal abscess", "Rectal fistula", "Rectal prolapse", "Recurrent", "Recurrent abscess formation", "Recurrent acute respiratory tract infection", "Recurrent aspergillus infections", "Recurrent aspiration pneumonia", "Recurrent bacterial infections", "Recurrent bacterial skin infections", "Recurrent bronchitis", "Recurrent bronchopulmonary infections", "Recurrent corneal erosions", "Recurrent cutaneous abscess formation", "Recurrent ear infections", "Recurrent fever", "Recurrent fractures", "Recurrent gastroenteritis", "Recurrent hand flapping", "Recurrent herpes", "Recurrent hypoglycemia", "Recurrent infection of the gastrointestinal tract", "Recurrent joint dislocation", "Recurrent lower respiratory tract infections", "Recurrent mycobacterial infections", "Recurrent opportunistic infections", "Recurrent otitis media", "Recurrent pancreatitis", "Recurrent paroxysmal headache", "Recurrent pharyngitis", "Recurrent pneumonia", "Recurrent respiratory infections", "Recurrent sinopulmonary infections", "Recurrent sinusitis", "Recurrent skin infections", "Recurrent staphylococcal infections", "Recurrent staphylococcus aureus infections", "Recurrent upper and lower respiratory tract infections", "Recurrent urinary tract infections", "Recurrent viral infections", "Red eye", "Red green dyschromatopsia", "Red hair", "Reduced antigen specific t cell proliferation", "Reduced antithrombin iii activity", "Reduced brain n acetyl aspartate level by mrs", "Reduced c peptide level", "Reduced circulating prolactin concentration", "Reduced consciousness confusion", "Reduced delayed hypersensitivity", "Reduced factor viii activity", "Reduced factor xi activity", "Reduced factor xii activity", "Reduced factor xiii activity", "Reduced forced expiratory volume in one second", "Reduced forced vital capacity", "Reduced natural killer cell count", "Reduced pancreatic beta cells", "Reduced protein c activity", "Reduced protein s activity", "Reduced renal corticomedullary differentiation", "Reduced sperm motility", "Reduced subcutaneous adipose tissue", "Reduced systolic function", "Reduced tendon reflexes", "Reduced visual acuity", "Reduced vital capacity", "Reduction of neutrophil motility", "Redundant neck skin", "Redundant skin", "Refractory anemia", "Regional abnormality of skin", "Relative macrocephaly", "Renal agenesis", "Renal angiomyolipoma", "Renal cell carcinoma", "Renal cortical cysts", "Renal cortical microcysts", "Renal corticomedullary cysts", "Renal cyst", "Renal duplication", "Renal dysplasia", "Renal fanconi syndrome", "Renal fibrosis", "Renal hamartoma", "Renal hypoplasia", "Renal hypoplasia aplasia", "Renal insufficiency", "Renal magnesium wasting", "Renal malrotation", "Renal phosphate wasting", "Renal potassium wasting", "Renal salt wasting", "Renal steatosis", "Renal tubular acidosis", "Renal tubular atrophy", "Renal tubular dysfunction", "Renal tubular epithelial necrosis", "Renovascular hypertension", "Repetitive compulsive behavior", "Respiratory alkalosis", "Respiratory arrest", "Respiratory distress", "Respiratory failure", "Respiratory failure requiring assisted ventilation", "Respiratory insufficiency", "Respiratory insufficiency due to defective ciliary clearance", "Respiratory paralysis", "Respiratory tract infection", "Response to drugs acting on neuromuscular transmission", "Resting tremor", "Restless legs", "Restlessness", "Restrictive behavior", "Restrictive cardiomyopathy", "Restrictive ventilatory defect", "Reticular hyperpigmentation", "Reticulated skin pigmentation", "Reticulocytopenia", "Reticulocytosis", "Retinal arterial tortuosity", "Retinal arteriolar tortuosity", "Retinal atrophy", "Retinal coloboma", "Retinal degeneration", "Retinal detachment", "Retinal dysplasia", "Retinal dystrophy", "Retinal fold", "Retinal hamartoma", "Retinal hemorrhage", "Retinal neovascularization", "Retinal perforation", "Retinal pigment epithelial atrophy", "Retinal pigment epithelial mottling", "Retinal telangiectasia", "Retinal thinning", "Retinal vascular tortuosity", "Retinopathy", "Retrocollis", "Retrognathia", "Rhabdomyolysis", "Rhabdomyosarcoma", "Rhegmatogenous retinal detachment", "Rheumatoid arthritis", "Rheumatoid factor positive", "Rhinitis", "Rhizomelia", "Rib fusion", "Rib segmentation abnormalities", "Rickets", "Ridged nail", "Rieger anomaly", "Right bundle branch block", "Right ventricular cardiomyopathy", "Right ventricular dilatation", "Right ventricular hypertrophy", "Rigidity", "Rimmed vacuoles", "Rod cone dystrophy", "Rotary nystagmus", "Round ear", "Round face", "Saccadic oscillation", "Saccadic smooth pursuit", "Sagittal craniosynostosis", "Sandal gap", "Sarcoma", "Scaling skin", "Scanning speech", "Scaphocephaly", "Scapular winging", "Scarring", "Scarring alopecia of scalp", "Schistocytosis", "Schizencephaly", "Schizophrenia", "Schwannoma", "Scleral staphyloma", "Sclerocornea", "Scleroderma", "Sclerosis of hand bone", "Sclerosis of skull base", "Sclerotic vertebral endplates", "Scotoma", "Scrotal hypoplasia", "Sea blue histiocytosis", "Seborrheic dermatitis", "Second degree atrioventricular block", "Secondary amenorrhea", "Secondary growth hormone deficiency", "Secondary microcephaly", "Secretory diarrhea", "Secundum atrial septal defect", "Segmental peripheral demyelination remyelination", "Selective tooth agenesis", "Self injurious behavior", "Self mutilation", "Semilobar holoprosencephaly", "Senile plaques", "Sensorimotor neuropathy", "Sensory ataxia", "Sensory axonal neuropathy", "Sensory neuropathy", "Sepsis", "Septate vagina", "Septic arthritis", "Septo optic dysplasia", "Serositis", "Severe combined immunodeficiency", "Severe cytomegalovirus infection", "Severe demyelination of the white matter", "Severe expressive language delay", "Severe failure to thrive", "Severe global developmental delay", "Severe hearing impairment", "Severe infection", "Severe intrauterine growth retardation", "Severe lactic acidosis", "Severe muscular hypotonia", "Severe photosensitivity", "Severe postnatal growth retardation", "Severe short limb dwarfism", "Severe short stature", "Severe varicella zoster infection", "Severe viral infection", "Severely reduced visual acuity", "Sex reversal", "Shagreen patch", "Shallow acetabular fossae", "Shallow anterior chamber", "Shallow orbits", "Shawl scrotum", "Shield chest", "Shock", "Short 1st metacarpal", "Short attention span", "Short chin", "Short clavicles", "Short columella", "Short digit", "Short face", "Short femur", "Short foot", "Short lingual frenulum", "Short long bone", "Short lower limbs", "Short middle phalanx of finger", "Short nail", "Short nose", "Short palm", "Short palpebral fissure", "Short phalanx of the thumb", "Short philtrum", "Short proximal phalanx of finger", "Short ribs", "Short stepped shuffling gait", "Short sternum", "Short thorax", "Short thumb", "Short tibia", "Short umbilical cord", "Short upper lip", "Shortened pr interval", "Shortened qt interval", "Shortening of all distal phalanges of the fingers", "Shortening of all middle phalanges of the fingers", "Shoulder dislocation", "Shoulder girdle muscle atrophy", "Shoulder girdle muscle weakness", "Shoulder pain", "Shuffling gait", "Shyness", "Sick sinus syndrome", "Sideroblastic anemia", "Simple ear", "Simple febrile seizure", "Simplified gyral pattern", "Single fiber emg abnormality", "Single naris", "Single transverse palmar crease", "Single ventricle", "Sinus bradycardia", "Sinus tachycardia", "Sirenomelia", "Skeletal dysplasia", "Skeletal muscle atrophy", "Skeletal muscle hypertrophy", "Skeletal myopathy", "Skin appendage neoplasm", "Skin dimple", "Skin erosion", "Skin nodule", "Skin picking", "Skin pit", "Skin plaque", "Skin rash", "Skin tags", "Skin ulcer", "Skin vesicle", "Skull asymmetry", "Slanting of the palpebral fissure", "Sleep apnea", "Sleep disturbance", "Sleep wake cycle disturbance", "Slender build", "Slender finger", "Slender long bone", "Sloping forehead", "Slow decrease in visual acuity", "Slow pupillary light response", "Slow saccadic eye movements", "Slowed slurred speech", "Slowly progressive", "Slurred speech", "Small anterior fontanelle", "Small basal ganglia", "Small earlobe", "Small epiphyses", "Small face", "Small for gestational age", "Small hand", "Small intestinal dysmotility", "Small nail", "Small placenta", "Smooth muscle antibody positivity", "Smooth philtrum", "Snoring", "Social and occupational deterioration", "Soft doughy skin", "Soft skin", "Soft tissue sarcoma", "Solitary median maxillary central incisor", "Somatic mutation", "Somatic sensory dysfunction", "Sound sensitivity", "Sparse and thin eyebrow", "Sparse body hair", "Sparse eyebrow", "Sparse eyelashes", "Sparse hair", "Sparse lateral eyebrow", "Sparse or absent eyelashes", "Sparse scalp hair", "Spastic ataxia", "Spastic diplegia", "Spastic dysarthria", "Spastic gait", "Spastic hyperactive bladder", "Spastic paraparesis", "Spastic paraparetic gait", "Spastic paraplegia", "Spastic tetraparesis", "Spastic tetraplegia", "Spasticity", "Specific learning disability", "Speech apraxia", "Speech articulation difficulties", "Spina bifida", "Spina bifida occulta", "Spinal canal stenosis", "Spinal cord compression", "Spinal cord lesion", "Spinal cord tumor", "Spinal deformities", "Spinal muscular atrophy", "Spinal rigidity", "Spinocerebellar tract degeneration", "Splanchnic vein thrombosis", "Splenomegaly", "Split nail", "Spoken word recognition deficit", "Spondyloepimetaphyseal dysplasia", "Spondyloepiphyseal dysplasia", "Spondylolisthesis", "Spondylolysis", "Spontaneous abortion", "Spontaneous hemolytic crises", "Spontaneous pain sensation", "Spontaneous recurrent epistaxis", "Sporadic", "Spotty hyperpigmentation", "Sprengel anomaly", "Squamous cell carcinoma", "Squamous cell carcinoma of the skin", "Square face", "Squared iliac bones", "St segment elevation", "Stage 5 chronic kidney disease", "Staring gaze", "Status epilepticus", "Status epilepticus with prominent motor symptoms", "Stenosis of the external auditory canal", "Steppage gait", "Stereotypical body rocking", "Stereotypical hand wringing", "Stereotypy", "Steroid resistant nephrotic syndrome", "Stiff skin", "Stillbirth", "Stomach cancer", "Stomatitis", "Stomatocytosis", "Stooped posture", "Streak ovary", "Striae distensae", "Stridor", "Stroke", "Stroke like episode", "Stuttering", "Subacute progressive viral hepatitis", "Subarachnoid hemorrhage", "Subcapsular cataract", "Subcortical band heterotopia", "Subcortical cerebral atrophy", "Subcortical heterotopia", "Subcutaneous hemorrhage", "Subcutaneous nodule", "Subdural hemorrhage", "Subependymal cysts", "Subglottic stenosis", "Submucous cleft of soft and hard palate", "Submucous cleft soft palate", "Subretinal fluid", "Subsarcolemmal accumulations of abnormally shaped mitochondria", "Substantia nigra gliosis", "Subvalvular aortic stenosis", "Sudden death", "Sudden episodic apnea", "Sudden loss of visual acuity", "Suicidal ideation", "Sunken cheeks", "Supernumerary bones of the axial skeleton", "Supernumerary nipple", "Supernumerary spleens", "Supernumerary tooth", "Supranuclear gaze palsy", "Supranuclear ophthalmoplegia", "Supravalvular aortic stenosis", "Supraventricular arrhythmia", "Supraventricular tachycardia", "Symphalangism affecting the phalanges of the hand", "Symphalangism of middle phalanx of finger", "Symptomatic seizures", "Syncope", "Syndactyly", "Synostosis involving bones of the hand", "Synostosis involving bones of the lower limbs", "Synostosis involving bones of the upper limbs", "Synostosis involving digits", "Synostosis of carpal bones", "Synostosis of carpals tarsals", "Synostosis of joints", "Synostosis of metacarpals metatarsals", "Synovitis", "Syringomyelia", "Systemic lupus erythematosus", "T cell lymphoma", "T lymphocytopenia", "Tachycardia", "Tachypnea", "Talipes calcaneovalgus", "Talipes equinovalgus", "Talipes equinovarus", "Talipes valgus", "Tall stature", "Tapered distal phalanges of finger", "Tapered finger", "Tarsal synostosis", "Telangiectasia", "Telangiectasia of the skin", "Telecanthus", "Temperature instability", "Temporal cortical atrophy", "Temporal optic disc pallor", "Temporal pattern", "Tendon xanthomatosis", "Tented upper lip vermilion", "Teratoma", "Testicular adrenal rest tumor", "Testicular atrophy", "Testicular dysgenesis", "Tetany", "Tetralogy of fallot", "Tetraparesis", "Tetraplegia", "Tetraplegia tetraparesis", "Thenar muscle atrophy", "Thick cerebral cortex", "Thick corpus callosum", "Thick eyebrow", "Thick hair", "Thick lower lip vermilion", "Thick nasal alae", "Thick upper lip vermilion", "Thick vermilion border", "Thickened calvaria", "Thickened cortex of long bones", "Thickened ears", "Thickened helices", "Thickened nuchal skin fold", "Thickened ribs", "Thickened skin", "Thin bony cortex", "Thin clavicles", "Thin eyebrow", "Thin lower lip vermilion", "Thin nail", "Thin ribs", "Thin skin", "Thin upper lip vermilion", "Thin vermilion border", "Third degree atrioventricular block", "Thoracic aortic aneurysm", "Thoracic hypoplasia", "Thoracic kyphoscoliosis", "Thoracic kyphosis", "Thoracic scoliosis", "Thoracolumbar kyphoscoliosis", "Thoracolumbar kyphosis", "Thoracolumbar scoliosis", "Thrombocytosis", "Thromboembolism", "Thyroid adenoma", "Thyroid carcinoma", "Thyroiditis", "Tibial bowing", "Tibial torsion", "Tics", "Tiger tail banding", "Tinnitus", "Tip toe gait", "Tissue ischemia", "Titubation", "Toe clinodactyly", "Toe syndactyly", "Toe walking", "Toenail dysplasia", "Tongue atrophy", "Tongue fasciculations", "Tongue nodules", "Tongue thrusting", "Tonic seizure", "Tooth malposition", "Torsade de pointes", "Torsion dystonia", "Total anomalous pulmonary venous return", "Toxemia of pregnancy", "Tracheal stenosis", "Tracheobronchomalacia", "Tracheoesophageal fistula", "Tracheomalacia", "Tractional retinal detachment", "Transient global amnesia", "Transient ischemic attack", "Transient neutropenia", "Transposition of the great arteries", "Tremor", "Tremor by anatomical site", "Triangular face", "Triangular mouth", "Triangular shaped phalanges of the hand", "Triceps weakness", "Trichorrhexis nodosa", "Tricuspid atresia", "Tricuspid stenosis", "Tricuspid valve prolapse", "Trigonocephaly", "Triphalangeal thumb", "Trismus", "Tritanomaly", "Trophic changes related to pain", "Truncal ataxia", "Truncal obesity", "Truncal titubation", "Truncus arteriosus", "Tube feeding", "Tubulointerstitial nephritis", "Turricephaly", "Type 1 fibers relatively smaller than type 2 fibers", "Type 1 muscle fiber atrophy", "Type 2 muscle fiber atrophy", "Type 2 muscle fiber predominance", "Type i diabetes mellitus", "Type i transferrin isoform profile", "Type ii diabetes mellitus", "Type ii lissencephaly", "Type ii transferrin isoform profile", "Typical absence seizure", "U shaped upper lip vermilion", "Ulnar bowing", "Ulnar claw", "Ulnar deviation of finger", "Ulnar deviation of the 2nd finger", "Ulnar deviation of the hand", "Ulnar deviation of the hand or of fingers of the hand", "Ulnar deviation of the wrist", "Uncombable hair", "Unconjugated hyperbilirubinemia", "Underdeveloped nasal alae", "Underdeveloped supraorbital ridges", "Underdeveloped tragus", "Undetectable electroretinogram", "Undetectable light and dark adapted electroretinogram", "Undetectable visual evoked potentials", "Unexplained fevers", "Unilateral cleft lip", "Unilateral ptosis", "Unilateral renal agenesis", "Unsteady gait", "Unusual fungal infection", "Unusual infection", "Unusual infection by anatomical site", "Unusual skin infection", "Upgaze palsy", "Upper airway obstruction", "Upper extremity joint dislocation", "Upper eyelid coloboma", "Upper limb amyotrophy", "Upper limb asymmetry", "Upper limb hypertonia", "Upper limb muscle weakness", "Upper limb pain", "Upper limb postural tremor", "Upper limb spasticity", "Upper limb undergrowth", "Upper motor neuron dysfunction", "Upslanted palpebral fissure", "Ureteral duplication", "Ureteral obstruction", "Ureteral stenosis", "Ureterocele", "Ureteropelvic junction obstruction", "Urethral obstruction", "Urethral stenosis", "Urethral stricture", "Urethral valve", "Urethrovaginal fistula", "Uric acid nephrolithiasis", "Urinary bladder sphincter dysfunction", "Urinary glycosaminoglycan excretion", "Urinary incontinence", "Urinary retention", "Urinary tract neoplasm", "Urinary urgency", "Urogenital fistula", "Urogenital sinus anomaly", "Urticaria", "Uterine prolapse", "Uterus didelphys", "Uveal melanoma", "Uveitis", "Vacuolated lymphocytes", "Vaginal atresia", "Vaginal fistula", "Vaginal neoplasm", "Variable expressivity", "Varicose veins", "Vascular calcification", "Vascular dilatation", "Vascular neoplasm", "Vascular skin abnormality", "Vascular tortuosity", "Vasculitis", "Vegetative state", "Vein of galen aneurysmal malformation", "Velopharyngeal insufficiency", "Venous insufficiency", "Venous malformation", "Venous thrombosis", "Ventricular arrhythmia", "Ventricular escape rhythm", "Ventricular fibrillation", "Ventricular hypertrophy", "Ventricular preexcitation", "Ventricular septal hypertrophy", "Ventricular tachycardia", "Ventriculomegaly", "Verrucae", "Vertebral arch anomaly", "Vertebral clefting", "Vertebral compression fracture", "Vertebral fusion", "Vertebral hypoplasia", "Vertebral segmentation defect", "Vertebral wedging", "Vertical nystagmus", "Vertical supranuclear gaze palsy", "Vertigo", "Very long chain fatty acid accumulation", "Vestibular dysfunction", "Viral encephalitis", "Viral hepatitis", "Viral infection induced rhabdomyolysis", "Visceral angiomatosis", "Visual acuity test abnormality", "Visual agnosia", "Visual field defect", "Visual fixation instability", "Visual hallucinations", "Visual impairment", "Visual loss", "Vitiligo", "Vitreoretinopathy", "Vitreous floaters", "Vitreous hemorrhage", "Vitritis", "Vocal cord paralysis", "Vocal cord paresis", "Volvulus", "Vomiting", "Waddling gait", "Weak cry", "Weak voice", "Weakness due to upper motor neuron dysfunction", "Weakness of facial musculature", "Weakness of long finger extensor muscles", "Weakness of muscles of respiration", "Weakness of the intrinsic hand muscles", "Webbed neck", "Weight loss", "Wheezing", "White forelock", "White hair", "Wide anterior fontanel", "Wide cranial sutures", "Wide intermamillary distance", "Wide mouth", "Wide nasal bridge", "Wide nasal ridge", "Wide nose", "Widely patent fontanelles and sutures", "Widely spaced incisors", "Widely spaced teeth", "Widened cerebral subarachnoid space", "Widened subarachnoid space", "Widow s peak", "Woolly hair", "Wormian bones", "Wrist flexion contracture", "Writer s cramp", "X linked dominant inheritance", "X linked recessive inheritance", "Xanthelasma", "Xanthomatosis", "Xerostomia", "Y shaped metacarpals", "Yellow white lesions of the retina", "Young adult onset", "Zonular cataract"], "available_proteins": ["AAAS", "AARS", "AARS2", "ABCB1", "ABCB7", "ABCD3", "ABHD12", "ACACA", "ACAD9", "ACADM", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACO2", "ACOX1", "ACP2", "ACSF3", "ACSL4", "ACTL6A", "ACTN1", "ACTN2", "ACTN4", "ADAR", "ADD1", "ADD3", "ADH5", "ADK", "ADNP", "ADPRHL2", "ADSL", "AFG3L2", "AGK", "AGL", "AGPS", "AHCY", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AKT2", "ALDH18A1", "ALDH2", "ALDH3A2", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDOA", "ALG1", "ALG12", "ANAPC1", "ANKLE2", "ANKRD17", "ANLN", "ANO10", "ANXA11", "AP1B1", "AP1S2", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "APOL2", "APP", "APRT", "ARCN1", "ARHGDIA", "ARHGEF2", "ARID1A", "ARL2", "ARL3", "ARL6IP1", "ARSA", "ARV1", "ASAH1", "ASNA1", "ASNS", "ASPH", "ASPSCR1", "ATAD1", "ATAD3A", "ATIC", "ATP1A1", "ATP2A2", "ATP2C1", "ATP5A1", "ATP6", "ATP6AP1", "ATP6AP2", "ATP6V0A2", "ATP6V1A", "ATP6V1B2", "ATP6V1E1", "ATP7B", "ATXN10", "AURKA", "B4GAT1", "BAG3", "BANF1", "BAZ1B", "BCAP31", "BCS1L", "BICD2", "BLVRA", "BMS1", "BPTF", "BRAT1", "BUB1B", "BUB3", "BUD23", "C19orf70", "C1QBP", "CAD", "CALD1", "CALM3", "CALR", "CAMK2G", "CAPN1", "CARS", "CASK", "CAST", "CBL", "CBX2", "CCDC22", "CCDC47", "CCT5", "CD2AP", "CDC40", "CDC42", "CDC73", "CDK4", "CDK5", "CDK6", "CENPF", "CEP55", "CFL2", "CHAMP1", "CHD4", "CHM", "CHMP2B", "CHORDC1", "CHST14", "CHUK", "CISD2", "CIZ1", "CLASP1", "CLCC1", "CLCN7", "CLIP1", "CLN5", "CLPB", "CLPP", "CLPX", "CLTC", "CNNM4", "CNOT1", "CNOT2", "CNOT3", "CNP", "COL4A3BP", "COLEC12", "COLGALT1", "COMT", "COPA", "COPB1", "COPB2", "COQ8A", "COQ9", "CORO1A", "COX2", "COX4I1", "COX5A", "CPNE1", "CPOX", "CPSF1", "CPT2", "CRKL", "CRTAP", "CSNK2A1", "CSNK2B", "CSTB", "CTBP1", "CTH", "CTNNA1", "CTNNB1", "CTNND1", "CTPS1", "CTSA", "CTSB", "CTSC", "CTU2", "CUL3", "CUL4B", "CWF19L1", "CXorf56", "CYB5R3", "CYC1", "DARS", "DARS2", "DCPS", "DCTN1", "DCTN4", "DCXR", "DDB1", "DDOST", "DDRGK1", "DDX3X", "DDX41", "DDX6", "DHCR24", "DHCR7", "DHFR", "DHX16", "DHX30", "DHX37", "DIABLO", "DIAPH1", "DIAPH2", "DIAPH3", "DKC1", "DLAT", "DLD", "DLST", "DNA2", "DNAAF5", "DNAJC3", "DNM1L", "DNM2", "DNMT1", "DOCK7", "DPM1", "DPP9", "DPYSL5", "DSC3", "DSG2", "DSP", "DST", "DYNC1H1", "DYNC2H1", "DYNLL1", "ECE1", "ECHS1", "EDC3", "EEF1A2", "EEF2", "EFL1", "EFTUD2", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF3F", "EIF4A3", "EIF4G1", "EIF4H", "EIF5A", "ELAC2", "ELMO2", "ELP1", "ELP2", "ELP4", "EMC1", "EMD", "EMG1", "EPB41", "EPHX2", "EPRS", "EPS15L1", "ERAL1", "ERAP1", "ERCC2", "ERLIN1", "ERLIN2", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXOC2", "EXOC7", "EXOSC2", "EXOSC3", "EZR", "FAH", "FANCI", "FAR1", "FARSA", "FARSB", "FASN", "FBXO7", "FDFT1", "FDPS", "FECH", "FH", "FIP1L1", "FKBP10", "FKBP14", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FMR1", "FOXRED1", "FRG1", "FSCN1", "FTO", "FUCA1", "FUS", "FXR1", "G6PD", "GAA", "GALK1", "GALM", "GALNT2", "GANAB", "GAPVD1", "GARS", "GBA", "GCDH", "GCLC", "GDI1", "GEMIN4", "GEMIN5", "GFM1", "GFPT1", "GGCX", "GIGYF2", "GLA", "GLB1", "GLDC", "GLMN", "GLRX5", "GLS", "GLUD1", "GM2A", "GMPPB", "GNAI2", "GNAI3", "GNPAT", "GNS", "GOT2", "GPD2", "GPI", "GPKOW", "GRHPR", "GSR", "GSS", "GSTM3", "GTF2I", "GTPBP3", "GUF1", "GUSB", "H2AFY", "HADH", "HADHA", "HADHB", "HCCS", "HCFC1", "HELLS", "HEXA", "HEXB", "HIBCH", "HIST1H1E", "HK1", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HMBS", "HMGA1", "HMGB3", "HMOX1", "HNRNPA1", "HNRNPA2B1", "HNRNPDL", "HNRNPH2", "HNRNPK", "HNRNPU", "HPRT1", "HSD17B10", "HSD17B4", "HSPA9", "HSPB1", "HSPD1", "HUWE1", "HYOU1", "IARS", "IARS2", "IDH1", "IDH2", "IDH3A", "IDH3B", "IFT27", "IGBP1", "IGF2BP2", "IGF2R", "IMPDH1", "IRF2BPL", "IRS4", "ISCU", "ITPA", "IVD", "JUP", "KARS", "KDM1A", "KDM3B", "KDSR", "KIAA0319L", "KIF11", "KIF15", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF4A", "KIF7", "KIFBP", "KMT2A", "LARS", "LARS2", "LAS1L", "LBR", "LDHA", "LEMD2", "LEMD3", "LETM1", "LIPA", "LLGL1", "LMAN1", "LMNA", "LMNB1", "LMNB2", "LONP1", "LRBA", "LRPPRC", "LSS", "MACF1", "MAGED2", "MAN2B1", "MANBA", "MAP1B", "MAP2K1", "MAPK1", "MAPRE2", "MARS", "MAT2A", "MATR3", "MBOAT7", "MCCC1", "MCCC2", "MCM2", "MCM4", "MCM5", "MCM6", "MCM7", "MDH1", "MDH2", "MECP2", "MED23", "MED25", "MFN2", "MICU1", "MID1", "MIF", "MINPP1", "MIPEP", "MOGS", "MPI", "MRE11", "MRPL12", "MRPL3", "MRPL44", "MRPS2", "MRPS22", "MRPS23", "MRPS25", "MRPS28", "MRPS34", "MRPS35", "MRPS7", "MSH2", "MSH3", "MSH6", "MSN", "MSTO1", "MTAP", "MTCH1", "MTHFD1", "MTMR2", "MTOR", "MTPAP", "MTR", "MTX2", "MVK", "MYH14", "MYH9", "MYO6", "NAA15", "NAGLU", "NANS", "NARS", "NAXE", "NBN", "NCAPD2", "NCAPH", "NCDN", "NCSTN", "NDUFA10", "NDUFA4", "NDUFA9", "NDUFAF4", "NDUFB10", "NDUFB3", "NDUFS1", "NDUFS2", "NDUFS3", 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setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Lysosome 33 50 4.0779189115996175 4.544060798816752e-05 21.740291262135923 48.609223300970875 0.8281821627988494 0.1302152537326229 7.142313942893836 4.247239237941681 3.086075071395461 0.2389623217115766 1.0774394983071706e-30 2.572239846419652e-19 6.576113387129867e-28 1.7291122067419366e-33 3.249531523188541e-27 +Other glycan degradation 7 8 2.7031123960122363 0.0068693513551136 3.966019417475728 7.12378640776699 0.0449593300314452 0.158186848086018 1.7909726921672984 0.8075596903062239 1.9584092358200416 0.2320333335657103 2.3061589710032197e-08 4.548840906671602e-07 1.3836932757398312e-07 2.80712260492779e-10 6.662188105128115e-08 +Sphingolipid metabolism 9 12 2.595503104393968 0.0094452549698202 5.672330097087379 11.759708737864075 0.9805985471070467 0.1821702203806468 2.452838935293596 1.3449033287601222 1.7625559835482287 0.2542774311591588 2.531438004313328e-05 0.0063255491406275 0.0016986126979642 2.2879176712764704e-05 1.1025755752013924e-07 +Glycosaminoglycan degradation 5 6 2.506940660823344 0.0121781154130335 3.407766990291262 5.864077669902913 0.1350713234786387 0.1703873780123549 1.3379225542760151 0.7043353086258667 1.932540087143412 0.2532951180616937 4.394749746002936e-07 2.2261381171916983e-05 3.74476751148508e-06 1.5560435214860637e-07 9.033677057044543e-06 +Antigen processing and presentation 4 16 2.505181850759196 0.0122388449738728 5.337378640776699 16.74757281553398 0.2387870946403815 0.5680791453500826 2.8523982282892524 1.5499354612429144 0.9338462051385796 0.3189030666688743 0.0187034961823313 0.01497108596825 0.0061250241039257 0.0023536569339089 0.0387405426335318 +Cell adhesion molecules cams 4 6 2.376975701060092 0.0174552379476302 4.043689320388349 9.91019417475728 0.3640395302172229 0.4325707543794381 2.3114392567097153 2.512916721209252 1.1817978240178808 0.3174557953274378 0.1846123202718826 1.0 0.0149914480702132 0.0096445533674611 0.1193828224832026 +Steroid biosynthesis 6 9 2.141462710593198 0.0322367424882856 4.451456310679611 10.919902912621358 0.8535439655720318 0.1867209176898754 2.1463612955879627 1.3314318120676296 1.5430058140543457 0.1933818217769055 0.0009700532091562 0.0652597674910206 0.0002902447274798 1.3414362359281e-05 6.662188105128115e-08 +Calcium signaling pathway 5 13 2.086072431604738 0.0369720624896727 5.735436893203883 16.946601941747574 1.0005800740695592 0.3113014190776675 2.984654368989517 2.3866666657890168 1.2450167285670062 0.3187454651207294 0.2432253838948864 0.0388410242837302 0.1290920553826253 0.2083714330221484 0.0939197895351208 +Snare interactions in vesicular transport 4 8 2.053155604295512 0.0400574885881228 5.803398058252427 13.6626213592233 0.8920027438628428 0.3386294703372389 3.103034547770364 2.9171839264116786 1.2201519782198902 0.3219991979242683 1.0 1.0 1.0 0.5767416823779237 0.0255449311307142 diff --git a/msigdb_kegg/metrics.json b/msigdb_kegg/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..46ad586a8c1d3a7cc258131664823213600aece9 --- /dev/null +++ b/msigdb_kegg/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2644, + "annotations_size": 176, + "title": "Average number of proteins per term", + "value": 14.528409090909092 +} \ No newline at end of file diff --git a/msigdb_kegg/paths.json b/msigdb_kegg/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..bdf3fd292bfd568295525fb7c4f5f2b0d77baede --- /dev/null +++ b/msigdb_kegg/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/msigdb_kegg/fragment/C197/C197_val_log2fc"} \ No newline at end of file diff --git a/msigdb_kegg/result.tsv b/msigdb_kegg/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..dcb8f8f8e2cd79256272cb2375463678148ea784 --- /dev/null +++ b/msigdb_kegg/result.tsv @@ -0,0 +1,52 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Lysosome 0.8586668266629303 4.0779189115996175 4.5440607988167514e-05 0.0079658319762696 0.0079975470059176 50 Q13510,O75503,P07858,P50897,P06280,P07602,Q99538,P15586,Q14108,O00115,P06865,P11717,P16278,O00462,P61916,P11117,P54802,Q93050,O14773,P10619,Q8NCC3,P04066,P53634,P17900,Q99523,P10253,P11279,Q9Y487,P08236,P07686,O15118,Q15904,O00754 33 +Other glycan degradation 0.929059180576623 2.7031123960122363 0.0068693513551136 0.7027487376966269 0.3475746615446904 8 P16278,O00462,P07686,P04066,Q9BTY2,O00754,P06865 7 +Sphingolipid metabolism 0.7769011705779075 2.5955031043939676 0.0094452549698202 0.8118028870654931 0.3475746615446904 12 Q13510,P04062,P16278,O15269,P06280,O43681,Q06136,Q16739,O95470 9 +Glycosaminoglycan degradation 0.9586808188021196 2.506940660823344 0.0121781154130335 0.8842712535715437 0.3475746615446904 6 P16278,P08236,P15586,P54802,P06865 5 +Antigen processing and presentation 0.7157492514831978 2.505181850759196 0.0122388449738728 0.8855167464250359 0.3475746615446904 16 Q99538,P01889,P07858,P10321 4 +Cell adhesion molecules cams 0.9257087605260632 2.376975701060092 0.0174552379476302 0.954917013390264 0.3475746615446904 6 Q16625,Q92896,P01889,P10321 4 +Steroid biosynthesis 0.764835051509862 2.141462710593198 0.0322367424882856 0.9968712793419556 0.368802206468878 9 P38571,O75845,Q15392,Q16850,P48449,Q9UBM7 6 +Calcium signaling pathway 0.6700252787731267 2.086072431604738 0.0369720624896727 0.998680394931338 0.368802206468878 13 P12235,P45880,P21796,P16615,Q9Y277 5 +Snare interactions in vesicular transport 0.7799349326545574 2.0531556042955117 0.0400574885881228 0.9992498301614292 0.368802206468878 8 Q9UNK0,O15400,Q9P2W9,P51809 4 +Glycosphingolipid biosynthesis globo series 0.9575918212798205 1.9809518079496429 0.0475966782926229 0.9998127254977226 0.368802206468878 3 P06280,P06865 2 +Glycosphingolipid biosynthesis ganglio series 0.9575918212798205 1.9809518079496429 0.0475966782926229 0.9998127254977226 0.368802206468878 3 P16278,P06865 2 +Cardiac muscle contraction 0.6101840226565546 1.9587693444137235 0.050139805227632 0.999883021742782 0.368802206468878 17 P05026,P14406,O14949,P05023,Q9UDW1,P00403,P20674,P16615 8 +Vibrio cholerae infection 0.5990080763204553 1.9464414848106155 0.051601730453332 0.9999107984278548 0.368802206468878 20 Q93050,P24390,Q9Y487 3 +Folate biosynthesis 0.8392300837613196 1.827496153198825 0.0676252040649956 0.999995554379167 0.38896537624611 4 Q92820 1 +Allograft rejection 0.8348657293584546 1.809571579864426 0.0703622505202972 0.9999973501571756 0.38896537624611 4 P01889,P10321 2 +Graft versus host disease 0.8348657293584546 1.809571579864426 0.0703622505202972 0.9999973501571756 0.38896537624611 4 P01889,P10321 2 +Autoimmune thyroid disease 0.8348657293584546 1.809571579864426 0.0703622505202972 0.9999973501571756 0.38896537624611 4 P01889,P10321 2 +Renin angiotensin system 0.8343045345333127 1.8072649547194837 0.0707209774992927 0.9999975241775356 0.38896537624611 4 P10619,Q9UIQ6 2 +Type i diabetes mellitus 0.7672301418592167 1.6819273355086566 0.0925829312565789 0.9999999625007848 0.4407718413867946 5 P01889,P10321 2 +O glycan biosynthesis 0.7829545454545509 1.5946423203070168 0.1107922431956378 0.9999999989417928 0.4484064020823026 4 Q10472,O43505,Q10471 3 +Galactose metabolism 0.5810325497810179 1.5844453141514323 0.1130924169168499 0.9999999993292004 0.4484064020823026 13 P06280,P16278 2 +Ppar signaling pathway 0.579093832929302 1.5732198521874567 0.1156679200577766 0.9999999995979252 0.4484064020823026 13 P23786,Q15067,O14975 3 +Glycerophospholipid metabolism 0.5407990638744787 1.3922717373189468 0.1638401265688123 0.999999999999979 0.5884869852267545 14 P35790,Q92604,Q96N66,O15228,Q8NCC3,Q6P1A2,Q9HCL2 7 +Epithelial cell signaling in helicobacter pylori infection 0.5002794463001368 1.316451259246589 0.1880226274740828 1.0 0.6214686960456659 20 Q93050,Q9Y487 2 +Glycosaminoglycan biosynthesis chondroitin sulfate 0.8690386071158206 1.2022288879144978 0.229274859870987 1.0 0.6427439475901785 2 Q8NCH0 1 +Steroid hormone biosynthesis 0.8671461014383043 1.1945781971637173 0.2322518719030908 1.0 0.6427439475901785 2 P21964 1 +Oxidative phosphorylation 0.4503881324287818 1.169886624586516 0.2420465972053678 1.0 0.6454575925476475 52 O96000,Q9Y487,O14949,P14406,O75306,Q9UDW1,O43676,Q93050,Q15904,O75964 10 +Natural killer cell mediated cytotoxicity 0.5024100991053593 1.0834195383598246 0.2786222471435278 1.0 0.6810766041286235 12 P01889,P10321 2 +Aldosterone regulated sodium reabsorption 0.6143879698852355 1.0237207126900398 0.3059672092872183 1.0 0.7044132370951905 5 P05026,O14654 2 +Proximal tubule bicarbonate reclamation 0.5512550453282661 0.9661816411022854 0.3339532977880146 1.0 0.7346972551336323 8 P05026,Q9UBX3,P00367 3 +Parkinsons disease 0.4347305524581648 0.9368355579571094 0.3488431515828301 1.0 0.7468746830276783 46 O96000,O14949,P45880,P14406,Q9UDW1,O75306,O43676,P21796,Q9Y277 9 +Viral myocarditis 0.4696532111246858 0.8584484371353398 0.390644891105822 1.0 0.7797516154019593 11 P01889,P10321 2 +Nicotinate and nicotinamide metabolism 0.5595566299698195 0.7896204359185711 0.4297494698522162 1.0 0.7797516154019593 5 P43490 1 +Huntingtons disease 0.3742082081353132 0.7377024555300352 0.4606952796288386 1.0 0.801362333644656 63 O96000,O14949,P45880,P14406,Q9UDW1,O75306,O43676,P21796,Q9Y277 9 +Starch and sucrose metabolism 0.4380233061344635 0.7052069902037739 0.4806814318056527 1.0 0.801362333644656 12 P10253 1 +Porphyrin and chlorophyll metabolism 0.4608943685436643 0.704351179969714 0.4812141009637847 1.0 0.801362333644656 10 P08236,P30519,P36551 3 +Biosynthesis of unsaturated fatty acids 0.4646842448240836 0.5524470684020423 0.5806420900793761 1.0 0.8552344703014856 8 Q53GQ0,P40939,Q15067 3 +Axon guidance 0.3690872716588609 0.4366322858801032 0.6623780442590159 1.0 0.8831707256786879 21 P04899,Q15375,O94813 3 +Endocytosis 0.3638124819485343 0.3278083539490062 0.7430565705074565 1.0 0.9271391799117776 36 Q9H223,P01889,P02786,O95630,O00429,P04439,P10321 7 +Amyotrophic lateral sclerosis als 0.4105138716435771 0.3142980450326863 0.7532946828897886 1.0 0.9271391799117776 8 Q9BUN8,P07196 2 +Alzheimers disease 0.3536340096254414 0.3142902750514195 0.7533005836783193 1.0 0.9271391799117776 51 O96000,O14949,P14406,O75306,Q9UDW1,O43676,P05067,Q92542 8 +Retinol metabolism 0.4991545670717205 0.2779600564241306 0.781043021242003 1.0 0.9420121287346744 3 Q8TC12 1 +Hedgehog signaling pathway 0.4960242332449818 0.2703902336986368 0.7868600527607714 1.0 0.9420121287346744 3 P48729,P49841 2 +Basal cell carcinoma 0.4479363877319184 0.1703086465989585 0.8647674115986919 1.0 0.9963939890533388 3 P49841,P35222 2 +N glycan biosynthesis 0.3352907127879959 0.1490243822432989 0.8815343935415019 1.0 1.0 12 P46977,O75340,Q9BV10,Q9BT22 4 +Primary bile acid biosynthesis 0.5162755488266387 0.1261841332257681 0.8995861708201995 1.0 1.0 2 P51659 1 +Abc transporters 0.4117905131299706 0.1156828356573919 0.9079039100715928 1.0 1.0 3 P08183 1 +Hypertrophic cardiomyopathy hcm 0.3519784383892695 0.0970218773727187 0.9227090207780562 1.0 1.0 8 P50402,P16615 2 +Dilated cardiomyopathy 0.3497105901735253 0.068049807215987 0.9457459857181544 1.0 1.0 7 P50402 1 +Olfactory transduction 0.3542770628311799 0.0410138147297799 0.9672848825676026 1.0 1.0 2 Q13555 1 +Amino sugar and nucleotide sugar metabolism 0.2971127981208791 0.0203158462241617 0.9837914149370636 1.0 1.0 20 P06865 1 diff --git a/msigdb_kegg/selections.json b/msigdb_kegg/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..adbc60db173f720a9e30e9b893379ffb85d8eb7e --- /dev/null +++ b/msigdb_kegg/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["Abc transporters", "Acute myeloid leukemia", "Adherens junction", "Adipocytokine signaling pathway", "Alanine aspartate and glutamate metabolism", "Aldosterone regulated sodium reabsorption", "Allograft rejection", "Alpha linolenic acid metabolism", "Alzheimers disease", "Amino sugar and nucleotide sugar metabolism", "Aminoacyl trna biosynthesis", "Amyotrophic lateral sclerosis als", "Antigen processing and presentation", "Apoptosis", "Arachidonic acid metabolism", "Arginine and proline metabolism", "Arrhythmogenic right ventricular cardiomyopathy arvc", "Ascorbate and aldarate metabolism", "Autoimmune thyroid disease", "Axon guidance", "B cell receptor signaling pathway", "Basal cell carcinoma", "Basal transcription factors", "Base excision repair", "Beta alanine metabolism", "Biosynthesis of unsaturated fatty acids", "Bladder cancer", "Butanoate metabolism", "Calcium signaling pathway", "Cardiac muscle contraction", "Cell adhesion molecules cams", "Cell cycle", "Chemokine signaling pathway", "Chronic myeloid leukemia", "Citrate cycle tca cycle", "Colorectal cancer", "Cysteine and methionine metabolism", "Cytokine cytokine receptor interaction", "Cytosolic dna sensing pathway", "Dilated cardiomyopathy", "Dna replication", "Dorso ventral axis formation", "Drug metabolism cytochrome p450", "Drug metabolism other enzymes", "Ecm receptor interaction", "Endocytosis", "Endometrial cancer", "Epithelial cell signaling in helicobacter pylori infection", "Erbb signaling pathway", "Ether lipid metabolism", "Fatty acid metabolism", "Fc epsilon ri signaling pathway", "Fc gamma r mediated phagocytosis", "Focal adhesion", "Folate biosynthesis", "Fructose and mannose metabolism", "Galactose metabolism", "Gap junction", "Glioma", "Glutathione metabolism", "Glycerolipid metabolism", "Glycerophospholipid metabolism", "Glycine serine and threonine metabolism", "Glycolysis gluconeogenesis", "Glycosaminoglycan biosynthesis chondroitin sulfate", "Glycosaminoglycan biosynthesis keratan sulfate", "Glycosaminoglycan degradation", "Glycosphingolipid biosynthesis ganglio series", "Glycosphingolipid biosynthesis globo series", "Glycosphingolipid biosynthesis lacto and neolacto series", "Glycosylphosphatidylinositol gpi anchor biosynthesis", "Glyoxylate and dicarboxylate metabolism", "Gnrh signaling pathway", "Graft versus host disease", "Hedgehog signaling pathway", "Hematopoietic cell lineage", "Histidine metabolism", "Homologous recombination", "Huntingtons disease", "Hypertrophic cardiomyopathy hcm", "Inositol phosphate metabolism", "Insulin signaling pathway", "Jak stat signaling pathway", "Leishmania infection", "Leukocyte transendothelial migration", "Limonene and pinene degradation", "Long term depression", "Long term potentiation", "Lysine degradation", "Lysosome", "Mapk signaling pathway", "Melanogenesis", "Melanoma", "Metabolism of xenobiotics by cytochrome p450", "Mismatch repair", "Mtor signaling pathway", "N glycan biosynthesis", "Natural killer cell mediated cytotoxicity", "Neuroactive ligand receptor interaction", "Neurotrophin signaling pathway", "Nicotinate and nicotinamide metabolism", "Nitrogen metabolism", "Nod like receptor signaling pathway", "Non homologous end joining", "Non small cell lung cancer", "Notch signaling pathway", "Nucleotide excision repair", "O glycan biosynthesis", "Olfactory transduction", "One carbon pool by folate", "Oocyte meiosis", "Other glycan degradation", "Oxidative phosphorylation", "P53 signaling pathway", "Pancreatic cancer", "Pantothenate and coa biosynthesis", "Parkinsons disease", "Pathogenic escherichia coli infection", "Pathways in cancer", "Pentose and glucuronate interconversions", "Pentose phosphate pathway", "Peroxisome", "Phenylalanine metabolism", "Phosphatidylinositol signaling system", "Porphyrin and chlorophyll metabolism", "Ppar signaling pathway", "Primary bile acid biosynthesis", "Prion diseases", "Progesterone mediated oocyte maturation", "Propanoate metabolism", "Prostate cancer", "Proteasome", "Protein export", "Proximal tubule bicarbonate reclamation", "Purine metabolism", "Pyrimidine metabolism", "Pyruvate metabolism", "Regulation of actin cytoskeleton", "Regulation of autophagy", "Renal cell carcinoma", "Renin angiotensin system", "Retinol metabolism", "Riboflavin metabolism", "Ribosome", "Rig i like receptor signaling pathway", "Rna degradation", "Rna polymerase", "Selenoamino acid metabolism", "Small cell lung cancer", "Snare interactions in vesicular transport", "Sphingolipid metabolism", "Spliceosome", "Starch and sucrose metabolism", "Steroid biosynthesis", "Steroid hormone biosynthesis", "Sulfur metabolism", "Systemic lupus erythematosus", "T cell receptor signaling pathway", "Terpenoid backbone biosynthesis", "Tgf beta signaling pathway", "Thyroid cancer", "Tight junction", "Toll like receptor signaling pathway", "Tryptophan metabolism", "Type i diabetes mellitus", "Type ii diabetes mellitus", "Tyrosine metabolism", "Ubiquitin mediated proteolysis", "Valine leucine and isoleucine biosynthesis", "Valine leucine and isoleucine degradation", "Vascular smooth muscle contraction", "Vasopressin regulated water reabsorption", "Vegf signaling pathway", "Vibrio cholerae infection", "Viral myocarditis", "Wnt signaling pathway"], "available_proteins": ["AARS", "AARS2", "AASDHPPT", "ABCB1", "ABCB7", "ABCD3", "ACAA2", "ACACA", "ACACB", "ACADM", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACIN1", "ACLY", "ACO2", "ACOT7", "ACOX1", "ACOX3", "ACP1", "ACP2", "ACP6", "ACSL1", "ACSL3", "ACSL4", "ACTN1", "ACTN2", "ACTN4", "ADAR", "ADH5", "ADI1", "ADK", "ADSL", "ADSS", "AFDN", "AGK", "AGL", "AGPAT1", "AGPS", "AHCY", "AHCYL1", "AIFM1", "AK1", "AK2", "AK3", "AKR1A1", "AKR1B1", "AKT2", "ALDH18A1", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALG1", "ALG12", "ANAPC1", "ANAPC10", "ANAPC5", "ANAPC7", "AP1B1", "AP1G1", "AP1M1", "AP1S2", "AP2A1", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "APEX1", "APEX2", "APP", "APRT", "AQR", "ARFGAP1", "ARFGAP2", "ARHGDIA", "ARHGEF2", "ARPC1A", "ARPC2", "ARPC3", "ARPC4", "ARSA", "ASAH1", "ASNA1", "ASNS", "ATG3", "ATIC", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1D", "ATP6V1E1", "ATP6V1G1", "ATP6V1H", "AURKA", "B4GAT1", "BAIAP2", "BIRC6", "BLVRA", "BPNT1", "BUB1B", "BUB3", "BUD23", "BUD31", "CAB39", "CACYBP", "CAD", "CALD1", "CALM3", "CALR", "CAMK2G", "CANX", "CAPN1", "CAPN2", "CARS", "CASK", "CBL", "CBR1", "CCDC6", "CCNB1", "CCNB2", "CDC20", "CDC23", "CDC25C", "CDC27", "CDC34", "CDC40", "CDC42", "CDC5L", "CDK1", "CDK2", "CDK4", "CDK5", "CDK6", "CETN2", "CFL1", "CFL2", "CHERP", "CHKA", "CHMP2A", "CHMP2B", "CHORDC1", "CHST14", "CHUK", "CKB", "CKMT1A*", "CLN5", "CLTC", "CMAS", "CMPK1", "CNOT1", "CNOT2", "CNOT3", "CNOT4", "CNOT7", "CNOT9", "COMT", "COX2", "COX4I1", "COX5A", "COX6C", "COX7A2", "CPOX", "CPT2", "CRK", "CRKL", "CRNKL1", "CS", "CSGALNACT2", "CSK", "CSNK1A1", "CSNK2A1", "CSNK2A2", "CSNK2B", "CTBP1", "CTBP2", "CTH", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTPS2", "CTSA", "CTSB", "CTSC", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CXADR", "CYB5R1", "CYB5R3", "CYC1", "CYFIP1", "CYP51A1", "DARS", "DARS2", "DCPS", "DCTN1", "DCTN2", "DCTN4", "DCXR", "DDB1", "DDOST", "DDX23", "DDX39B", "DDX3X", "DDX42", "DDX46", "DDX5", "DDX6", "DERL1", "DFFA", "DHCR24", "DHCR7", "DHFR", "DHX15", "DHX16", "DHX8", "DIAPH1", "DIAPH2", "DIAPH3", "DIS3", "DLAT", "DLD", "DLST", "DNA2", "DNASE2", "DNM1L", "DNM2", "DNMT1", "DPM1", "DPYSL2", "DPYSL5", "DSG2", "DSP", "DTYMK", "DUSP3", "DUSP9", "DUT", "DYNC1H1", "DYNC1LI1", "DYNC1LI2", "DYNC2H1", "DYNLL1", "ECH1", "ECHS1", "ECI1", "ECI2", "ECSIT", "EDC3", "EDC4", "EFTUD2", "EHD1", "EHD4", "EIF4A3", "EIF4B", "EIF4E", "EIF4G1", "EIF4G2", "EIF4G3", "ELOB", "ELOC", "EMD", "ENAH", "ENDOD1", "ENO1", "ENO2", "EPB41", "EPB41L2", "EPHA7", "EPHX1", "EPHX2", "EPRS", "EPS15", "ERCC2", "ERO1A", "EXO1", "EXOC3", "EXOC7", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "EZR", "FAH", "FAR1", "FARSA", "FARSB", "FASN", "FAU", "FDFT1", "FDPS", "FECH", "FEN1", "FH", "FLAD1", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FUCA1", "FUCA2", "G6PD", "GAA", "GABARAPL2", "GALK1", "GALM", "GALNT1", "GALNT2", "GALNT7", "GANAB", "GAPDH", "GARS", "GART", "GBA", "GCAT", "GCDH", "GCLC", "GCLM", "GFPT1", "GGCT", "GGH", "GLA", "GLB1", "GLDC", "GLG1", "GLO1", "GLS", "GLUD1", "GM2A", "GMPPB", "GMPS", "GNA13", "GNAI1", "GNAI2", "GNAI3", "GNPAT", "GNPDA1", "GNS", "GOT1", "GOT2", "GPAM", "GPD2", "GPI", "GRB2", "GRHPR", "GSK3B", "GSR", "GSS", "GSTK1", "GSTM3", "GSTO1", "GSTZ1", "GTF2I", "GUSB", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACL1", "HADH", "HADHA", "HADHB", "HCCS", "HDAC2", "HEXA", "HEXB", "HIBADH", "HIBCH", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HMBS", "HMGB1", "HMGCS1", "HMOX1", "HMOX2", "HNRNPA1", "HNRNPA3", "HNRNPC", "HNRNPK", "HNRNPM", "HNRNPU", "HPRT1", "HSD17B10", "HSD17B12", "HSD17B4", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA1B", "HSPA4", "HSPA8", "HSPA9", "HSPB1", "HSPD1", "HUWE1", "IARS", "IARS2", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDI1", "IGF2BP1", "IGF2R", "IMPDH1", "IMPDH2", "IQGAP1", "IRS4", "ISYNA1", "ITGB1", "ITPA", "IVD", "JUP", "KARS", "KDELR1", "KDSR", "LAMP1", "LAP3", "LARS", "LARS2", "LCLAT1", "LDHA", "LDHB", "LGMN", "LIG1", "LIG3", "LIPA", "LLGL1", "LMNA", "LNPEP", "LPCAT1", "LPCAT3", "LPGAT1", "LSM2", "LSM6", "LSM7", "LSS", "LTA4H", "LYPLA1", "M6PR", "MAD2L1", "MAN2A1", "MAN2B1", "MANBA", "MAP2K1", "MAPK1", "MARCKS", "MARS", "MAT2A", "MAT2B", "MAVS", "MBOAT7", "MCCC1", "MCCC2", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MDH1", "MDH2", "ME1", "MGST2", "MGST3", "MID1", "MIF", "MINPP1", "MOGS", "MPHOSPH6", "MPI", "MPST", "MRE11", "MSH2", "MSH3", "MSH6", "MSN", "MTAP", "MTCH1", "MTHFD1", "MTHFD1L", "MTHFD2", "MTMR2", "MTMR6", "MTOR", "MTR", "MVK", "MYH10", "MYH14", "MYH9", "MYL6", "NAE1", "NAGLU", "NAMPT", "NANS", "NARS", "NBN", "NCBP1", "NCKAP1", "NCL", "NCSTN", "NDUFA10", "NDUFA3", "NDUFA4", "NDUFA5", "NDUFA7", "NDUFA9", "NDUFB10", "NDUFB3", "NDUFB4", "NDUFB5", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS6", "NDUFS7", "NDUFV1", "NDUFV2", "NEFL", "NEFM", "NLN", "NME1", "NME6", "NME7", "NNT", "NPC1", "NPC2", "NRP1", "NSD2", "NSDHL", "NSF", "NT5C2", "NTHL1", "NUDT12", "NUDT5", "OAT", "OCLN", "OCRL", "OGDH", "OXA1L", "P4HA1", "PAFAH1B1", "PAFAH1B2", "PAFAH1B3", "PAICS", "PAK1", "PAK2", "PANK4", "PAPOLA", "PAPSS1", "PARK7", "PARN", "PARP1", "PATL1", "PC", "PCBP1", "PCCA", "PCK2", "PCNA", "PDCD6", "PDCD6IP", "PDE6D", "PDHA1", "PDHB", "PDIA3", "PDIA4", "PECR", "PEX14", "PEX19", "PFAS", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGM3", "PGP", "PHF5A", "PHGDH", "PHKA1", "PIGT", "PIK3C2A", "PIK3R4", "PIN1", "PIP4K2C", "PISD", "PKM", "PKMYT1", "PLA2G15", "PLCG1", "PLK1", "PLOD1", "PLOD2", "PLRG1", "PMPCA", "PNP", "PNPT1", "POLA1", "POLA2", "POLD1", "POLD2", "POLD3", "POLDIP2", "POLE", "POLE3", "POLE4", "POLR1A", "POLR1B", "POLR1E", "POLR2A", "POLR2B", "POLR2C", "POLR2G", "POLR3A", "POLR3C", "PPA1", "PPA2", "PPAT", "PPID", "PPIH", "PPP1CA", "PPP1CB", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP5C", "PPT1", "PPT2", "PQBP1", "PRDX5", "PRDX6", "PRIM1", "PRIM2", "PRKAG1", "PRKAR1A", "PRKAR2A", "PRKCD", "PRKDC", "PRPF19", "PRPF3", "PRPF31", "PRPF38B", "PRPF4", "PRPF40A", "PRPF6", "PRPF8", "PRPS1", "PSAP", "PSAT1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD11", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD6", "PSMD7", "PSMD8", "PSME1", "PSME2", "PSME3", "PSME4", "PSMF1", "PTDSS1", "PTGES2", "PTPN1", "PTPN11", "PUF60", "PXMP2", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QDPR", "RAB13", "RAB23", "RAB5A", "RAB5B", "RAB5C", "RAC1", "RAD21", "RAD23A", "RAD23B", "RAD50", "RALA", "RAPGEF2", "RARS", "RARS2", "RB1", "RBM17", "RBM22", "RBM25", "RBM8A", "RBMX", "RCOR1", "RDH11", "RDX", "RELA", "RETSAT", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RHEB", "RNASEH2A", "ROCK1", "ROCK2", "RPA1", "RPA2", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPN1", "RPN2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RRM1", "RRM2", "RSL24D1", "RUFY1", "RUVBL1", "SAE1", "SARS", "SARS2", "SART1", "SC5D", "SCARB2", "SCD", "SCP2", "SDHA", "SDHB", "SEC11A", "SEC22B", "SEC61A1", "SEC61B", "SEC61G", "SEC62", "SEC63", "SEPHS1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SGPL1", "SH3GL1", "SH3GLB1", 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0.0032793156510341 1.1753753401460365e-07 1.427728949067382e-12 +Diseases of carbohydrate metabolism 4 7 2.278424565092634 0.0227012941895037 3.5024271844660193 9.050970873786408 0.3053509571481614 0.2820635836848948 1.390848707873377 1.194576753712748 1.470873952821233 0.2708232247081553 0.00030448629013 0.0053672672920639 0.0013262573806951 0.0001885722773553 0.0042587077964903 +Plasma lipoprotein assembly remodeling and clearance 3 11 2.2157949480072148 0.0267055486176028 3.495145631067961 16.83495145631068 -0.156267225907303 0.3789468896930614 2.0090754595317124 2.280551318877052 1.3521243953392292 0.296420660396241 0.0200095143839186 0.1755724648168266 0.0563311776114605 0.0155108289838298 0.1267920275725256 +Transport of inorganic cations anions and amino acids oligopeptides 6 8 2.1870834653217543 0.0287364314618758 3.45873786407767 9.99514563106796 1.347451847228265 0.1988162564497566 2.1544143797408783 1.7967002462592632 1.0339867286779445 0.2465647399589519 1.0 1.0 1.0 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74.18203883495146 1.5594110758345356 0.2555609300308859 10.717199959161563 6.26233677332747 2.0947329132902324 0.3569924888492793 6.501262236767728e-06 0.0047018670886403 0.011785471900189 8.431667526360785e-06 3.5393205084266182e-09 +Peptide ligand binding receptors 2 7 2.1000021757277323 0.0357286497334112 2.8640776699029127 6.796116504854369 1.193322814833652 0.1851946070449122 1.2850789986620814 0.7987760455175396 1.3206182868906609 0.2426624676455473 0.0017552448339215 6.765318543664244e-05 0.0005309775927247 0.0074273483269255 0.0009961752813945 +Class a 1 rhodopsin like receptors 2 7 2.1000021757277323 0.0357286497334112 2.8640776699029127 6.796116504854369 1.193322814833652 0.1851946070449122 1.2850789986620814 0.7987760455175396 1.3206182868906609 0.2426624676455473 0.0032903114147814 0.000130543400341 0.0010099703116007 0.0135296171343662 0.0027898710574492 +Insulin receptor recycling 2 11 2.092640169708253 0.0363812878666474 2.8058252427184467 9.75485436893204 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5.640776699029126 0.4367607020315134 0.3723162326956727 1.3914754509602176 1.0870318448371576 1.21665608087566 0.3078849576437732 0.0541972194107464 1.0 0.0255840399150975 0.0033024410276518 0.0073870683046854 +Pink1 prkn mediated mitophagy 5 8 2.073210930147474 0.0381526536181342 3.2815533980582523 8.473300970873787 1.395617281862234 0.1554977461962819 1.6230588150315317 0.9738153254376878 1.3577427922485954 0.2414588001366878 0.0017552448339215 0.0786913117950012 0.0113213926532688 0.00062382482254 9.825976589410204e-05 +Trans golgi network vesicle budding 6 35 2.034824173136992 0.0418685678515327 10.53640776699029 36.62378640776699 0.049458611821428 0.5755399655007756 4.812618396852807 3.083264760841391 1.1838693038940356 0.3533924794481698 0.0004773845082524 1.855128547768521e-05 4.970398066350319e-05 0.0002471633761616 0.0058138641656078 +Mitochondrial protein import 12 34 1.9720124578704172 0.0486081843868189 13.468446601941748 34.5873786407767 1.6025718162972953 0.1874419874946837 6.078090089851624 2.2108812815475147 1.8878681708577505 0.2901223460226844 0.0002020798652155 0.0028071579475431 0.0024373211620913 0.0005241078784284 3.610470941932925e-06 diff --git a/msigdb_reactome/metrics.json b/msigdb_reactome/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..7b2444247201e6fb36d261fc7fd2f90ef0fb79b5 --- /dev/null +++ b/msigdb_reactome/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2644, + "annotations_size": 1350, + "title": "Average number of proteins per term", + "value": 17.64074074074074 +} \ No newline at end of file diff --git a/msigdb_reactome/paths.json b/msigdb_reactome/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..aaf21f111ee7b1dfa56080d5af330f12a95ae7c8 --- /dev/null +++ b/msigdb_reactome/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/msigdb_reactome/fragment/C197/C197_val_log2fc"} \ No newline at end of file diff --git a/msigdb_reactome/result.tsv b/msigdb_reactome/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..c52e13560963ea8f962207cd4d65fd5f845497c9 --- /dev/null +++ b/msigdb_reactome/result.tsv @@ -0,0 +1,268 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Sphingolipid metabolism 0.8018384412826047 3.1529030983337742 0.0016165545911379 0.8874226281841073 0.8098242166162708 25 Q13510,P04062,P16278,Q9Y5P4,P10619,O15269,P06280,O43681,P07602,Q06136,P07686,Q16739,Q9NZJ7,Q96G23,P51648,O95470,P17900,P06865 18 +Glycosphingolipid metabolism 0.8275820996623307 3.0311353651360236 0.0024363599459646 0.9628614269788623 0.8098242166162708 15 Q13510,P16278,P10619,P06280,P07602,P07686,Q16739,P17900,P06865 9 +Glycosaminoglycan metabolism 0.85843551586982 2.997850480910313 0.0027189102974727 0.974663972497822 0.8098242166162708 12 Q8TB61,P16278,P08236,P15586,P07686,P54802,P06865,O43505 8 +Slc mediated transmembrane transport 0.7341466444818112 2.7339047255703837 0.0062588151579499 0.9997915795095832 0.8098242166162708 18 P12235,Q8TB61,P55011,P35613,Q15758,P53985,Q99808,Q9Y6M7,Q9UBX3,Q96QD8,P08195,Q70HW3,Q8TAD4 13 +Ion channel transport 0.7067424426985714 2.6204734649755426 0.0087807763250657 0.9999932529054896 0.8098242166162708 26 P05026,Q9Y487,P51798,P27105,P51790,Q9HD20,P61421,Q9C0H2,Q93050,P35670,Q15904 11 +Sphingolipid de novo biosynthesis 0.8241275367123388 2.5850136500474887 0.0097375142269564 0.9999981679329624 0.8098242166162708 10 O15270,Q9Y5P4,O15269,Q06136,Q96G23,P51648,O95470 7 +Regulation of insulin like growth factor igf transport and uptake by insulin like growth factor binding proteins igfbps 0.7449804846810821 2.543886985063182 0.0109626547580012 0.99999965554524 0.8098242166162708 14 Q9BTY2,Q02818,Q06481,P05067 4 +Cell surface interactions at the vascular wall 0.7539663994928856 2.4785501873961584 0.013191755101493 0.9999999836228356 0.8098242166162708 12 P05026,P62993,Q92896,P35613,P53985,P78310,P08195 7 +Keratan sulfate keratin metabolism 0.958317544524442 2.461801489580267 0.0138241156578455 0.9999999931069632 0.8098242166162708 5 P15586,P16278,O43505,P06865 4 +Stimuli sensing channels 0.9010311722019954 2.424730310187027 0.015319762637991 0.9999999991117212 0.8098242166162708 7 P27105,Q9C0H2 2 +Transferrin endocytosis and recycling 0.740021711873457 2.406598100909123 0.0161018787911801 0.9999999996961374 0.8098242166162708 12 P02786,Q93050,Q9Y487 3 +Insertion of tail anchored proteins into the endoplasmic reticulum membrane 0.7375496625364208 2.39377551801359 0.0166759515160197 0.9999999998618052 0.8098242166162708 12 Q7L5D6,P09601,P50402,O43681,P05067,P51648,P46379 7 +Transport of small molecules 0.5514196223307961 2.3854719455481854 0.0170572233166972 0.9999999999181312 0.8098242166162708 132 P12235,Q8TB61,P53985,P21796,Q9UBX3,Q9C0H2,P08195,P08183,Q92530,P20618,Q10713,P45880,P51798,P61916,P10644,P55011,P27105,P51790,O75477,Q99808,P61421,P16615,P49721,Q93050,P35670,Q9BUN8,P05026,P28074,P30519,Q8WTV0,P09601,P35613,P05198,Q15758,P49720,Q9UHQ9,P28070,Q70HW3,Q8TAD4,Q9Y277,P38571,Q99436,Q9Y487,P12236,P02786,P05023,Q9HD20,Q9Y6M7,O15118,Q96QD8,P28072,Q15904 52 +Mucopolysaccharidoses 0.9606060606060616 2.315014816472025 0.0206121212269652 0.999999999999385 0.8098242166162708 4 P15586,P16278,P54802 3 +Keratan sulfate degradation 0.9579545454545464 2.3046069900932458 0.0211885941369232 0.9999999999997222 0.8098242166162708 4 P15586,P16278,P06865 3 +Diseases of carbohydrate metabolism 0.8659514431057904 2.278424565092634 0.0227012941895037 0.9999999999999656 0.8098242166162708 7 P54802,P15586,P10253,P16278 4 +Hyaluronan uptake and degradation 0.94499704305169 2.2535844548928052 0.0242223221845185 0.9999999999999958 0.8098242166162708 4 P08236,P06865 2 +Hyaluronan metabolism 0.9449970430516896 2.2535844548928052 0.0242223221845185 0.9999999999999958 0.8098242166162708 4 P08236,P06865 2 +Plasma lipoprotein assembly remodeling and clearance 0.7132947208231536 2.2157949480072148 0.0267055486176028 1.0 0.8098242166162708 11 P61916,O15118,Q8WTV0 3 +Endosomal vacuolar pathway 0.9344696969696982 2.2119350006853016 0.0269711564275494 1.0 0.8098242166162708 4 Q9UIQ6,P01889,P10321 3 +Transport of inorganic cations anions and amino acids oligopeptides 0.8097189816156978 2.1870834653217543 0.0287364314618758 1.0 0.8098242166162708 8 P55011,Q9Y6M7,Q9UBX3,Q96QD8,P08195,Q70HW3 6 +Basigin interactions 0.8729735103976881 2.1648292669251807 0.0304007626300384 1.0 0.8098242166162708 6 P05026,P35613,P53985 3 +Mitophagy 0.6895627011735102 2.140795991377384 0.0322904933799732 1.0 0.8098242166162708 12 Q13501,P21796,Q9NS69 3 +Gpcr ligand binding 0.7975060421031077 2.1324168267196444 0.0329725953131305 1.0 0.8098242166162708 8 P07602,P05067 2 +Trafficking and processing of endosomal tlr 0.9900536023026762 2.1082013264932935 0.0350135786032368 1.0 0.8098242166162708 3 P07858 1 +Protein localization 0.4855274656428444 2.1027436221667224 0.0354881866341587 1.0 0.8098242166162708 69 Q99595,P12235,Q5JRX3,P05067,P21796,O75874,O14925,Q13505,Q10713,O14975,O60830,O43615,Q9Y3D6,P46379,Q7L5D6,Q9NS69,P09601,P50402,O43681,Q8N4H5,P51648,Q13190,Q15388,Q15067,Q9NR77 25 +Peptide ligand binding receptors 0.8239849992701085 2.1000021757277323 0.0357286497334112 1.0 0.8098242166162708 7 P07602,P05067 2 +Class a 1 rhodopsin like receptors 0.8239849992701085 2.1000021757277323 0.0357286497334112 1.0 0.8098242166162708 7 P07602,P05067 2 +Insulin receptor recycling 0.6898607382978685 2.0926401697082535 0.0363812878666474 1.0 0.8098242166162708 11 Q93050,Q9Y487 2 +Plasma lipoprotein clearance 0.7202500404921343 2.080140805571504 0.0375126197708679 1.0 0.8098242166162708 10 P61916,O15118,Q8WTV0 3 +Immunoregulatory interactions between a lymphoid and a non lymphoid cell 0.8508948245984607 2.074440724774621 0.0380383984186256 1.0 0.8098242166162708 6 P04439,Q5KU26,P01889,P10321 4 +Pink1 prkn mediated mitophagy 0.7843658828030857 2.073210930147474 0.0381526536181342 1.0 0.8098242166162708 8 Q9NS69,Q13501,P21796,Q8N4H5,O95140 5 +Trans golgi network vesicle budding 0.6000154339426343 2.0348241731369914 0.0418685678515327 1.0 0.8098242166162708 35 O75976,P11717,Q99523,P05067,P15586,O00115 6 +Hs gag degradation 0.9602423324498308 1.9913881424970723 0.0464382318310354 1.0 0.8098242166162708 3 P16278,P54802 2 +Heparan sulfate heparin hs gag metabolism 0.9602423324498308 1.9913881424970723 0.0464382318310354 1.0 0.8098242166162708 3 P16278,P54802 2 +Mitochondrial protein import 0.5923639817374204 1.9720124578704177 0.0486081843868189 1.0 0.8098242166162708 34 Q15388,Q99595,P12235,Q10713,O60830,O43615,Q9NS69,Q5JRX3,P21796,O14925,Q8N4H5,Q13505 12 +Chondroitin sulfate dermatan sulfate metabolism 0.8696969696969733 1.9519137929686357 0.0509484404242424 1.0 0.8098242166162708 4 P07686,Q8NCH0,P06865 3 +Iron uptake and transport 0.5974552448808532 1.9387299111591765 0.0525342344840067 1.0 0.8098242166162708 18 P02786,Q93050,Q15904,Q9Y487 4 +Ion transport by p type atpases 0.7222444547744229 1.9381654367079724 0.0526030420778915 1.0 0.8098242166162708 9 P05026,P05023,Q9HD20,P16615,P35670 5 +Lysosome vesicle biogenesis 0.6339826619210767 1.936432154621822 0.0528147944910915 1.0 0.8098242166162708 14 P15586,P51809,O00115,P05067 4 +Synaptic adhesion like molecules 0.8614090476080036 1.9181950651086777 0.0550862817445532 1.0 0.8098242166162708 4 O75955,O95197 2 +Rhoa gtpase cycle 0.5772807923434187 1.9157638455880683 0.0553951616237278 1.0 0.8098242166162708 38 Q8TAA9,O75955,P30519,P02786,P27105,O15173,Q07021,Q14739,Q9NQW6,Q15904 10 +Toll like receptor cascades 0.5896343716433369 1.8886986559197112 0.0589322188379295 1.0 0.8098242166162708 22 P07858,P05067 2 +Cholesterol biosynthesis 0.6133124933617567 1.8691945735575897 0.0615957489682552 1.0 0.8152378539916137 15 O75845,Q15392,Q16850,Q14739,Q9H2C2,P48449,Q9BWD1,Q9UBM7 8 +Sialic acid metabolism 0.8420647669170354 1.8391250616264745 0.0658967936291203 1.0 0.818023356901214 4 P16278 1 +Mitochondrial calcium ion transport 0.6158078548071234 1.8326757496307668 0.0668508057175765 1.0 0.818023356901214 14 P45880,P21796,Q9Y277 3 +Vitamin d calciferol metabolism 0.9177408831400372 1.8231228324668705 0.068284789181273 1.0 0.818023356901214 3 Q99538 1 +Diseases associated with glycosaminoglycan metabolism 0.9117758424839094 1.7993607006183596 0.0719616418970181 1.0 0.818023356901214 3 P07686,P06865 2 +Metabolism of steroid hormones 0.7797567736096471 1.777044819004576 0.0755608660059152 1.0 0.818023356901214 6 P30536,O95772,Q8NBQ5 3 +Peptide hormone metabolism 0.6223298233098477 1.7732033991088765 0.0761950090245304 1.0 0.818023356901214 12 O75787,P67812 2 +Rhob gtpase cycle 0.5793918013872448 1.772699217687732 0.0762785608133491 1.0 0.818023356901214 17 Q8TAA9,O75955,P02786,P27105,Q9NQW6 5 +Neutrophil degranulation 0.520459675807905 1.7699777679970596 0.0767308443473262 1.0 0.818023356901214 162 Q13510,P07858,O00584,P06280,P07602,O15260,P15586,O75874,Q9BTY2,P11717,Q9NQX7,P20618,P16278,P01889,O14975,O75787,O00462,P61916,P27105,P04439,Q93050,P30519,P10619,O00560,Q92820,P42785,P04066,P53634,P10321,P17900,P10253,P11279,P61225,P08236,P07686,Q92542,O00754 37 +Transport of bile salts and organic acids metal ions and amine compounds 0.8981446421809931 1.7449396233747985 0.0809953792123046 1.0 0.818023356901214 3 Q8TAD4,P35613 2 +Diseases of glycosylation 0.5917551766131818 1.7428106298325796 0.0813666989194641 1.0 0.818023356901214 15 P16278,P10619,P07686,O43505,P06865 5 +Ldl clearance 0.7119975347826206 1.7400353864416822 0.0818528045678395 1.0 0.818023356901214 8 P61916,O15118 2 +Pregnenolone biosynthesis 0.8139809012009178 1.723467676813338 0.0848039855504407 1.0 0.818023356901214 4 O95772 1 +Rac2 gtpase cycle 0.5522687488588431 1.681267648617184 0.0927109387664972 1.0 0.818023356901214 32 Q14126,P50402,P02786,O15173,Q14739,Q86XL3,Q13505 7 +Rhoc gtpase cycle 0.5554334797761219 1.6749114335220472 0.0939516099867467 1.0 0.818023356901214 26 Q8TAA9,O75955,P02786,P27105,Q07021,Q14739,Q9NQW6 7 +Egr2 and sox10 mediated initiation of schwann cell myelination 0.7637814392266957 1.667302240332248 0.0954543214046337 1.0 0.818023356901214 5 Q16850 1 +Rhoj gtpase cycle 0.5536106981253797 1.666817136090746 0.0955507717636399 1.0 0.818023356901214 18 Q8TAA9,P02786,P27105 3 +Class i peroxisomal membrane protein import 0.695869570663206 1.6642088923426612 0.0960706916475448 1.0 0.818023356901214 8 P28288,Q9Y3D6,P40855,O75381,Q9NR77,P51648 6 +Metabolism of cofactors 0.7528261032487182 1.6621282825999344 0.096487055850875 1.0 0.818023356901214 6 Q9NZJ6,O75874,P35270 3 +Synthesis of pc 0.719567226897954 1.640360588442713 0.1009302147751292 1.0 0.818023356901214 7 Q9NQZ5 1 +Ros and rns production in phagocytes 0.6268119416755297 1.599474025659192 0.1097153155311352 1.0 0.818023356901214 10 Q93050 1 +O linked glycosylation 0.7829545454545509 1.5946423203070168 0.1107922431956378 1.0 0.818023356901214 4 Q10471,Q10472,O43505 3 +O linked glycosylation of mucins 0.7829545454545509 1.5946423203070168 0.1107922431956378 1.0 0.818023356901214 4 Q10472,O43505,Q10471 3 +Binding and uptake of ligands by scavenger receptors 0.7093334668523303 1.5941874391654118 0.1108940590073988 1.0 0.818023356901214 7 Q8WTV0 1 +Extracellular matrix organization 0.5431405692225846 1.5910614567833945 0.1115957455836873 1.0 0.818023356901214 23 P07858,P35613,Q32P28,P05067,Q92542 5 +Incretin synthesis secretion and inactivation 0.7816792217020436 1.5893264210167006 0.1119867167306876 1.0 0.818023356901214 4 P67812 1 +Synthesis secretion and inactivation of glucagon like peptide 1 glp 1 0.7816792217020436 1.5893264210167006 0.1119867167306876 1.0 0.818023356901214 4 P67812 1 +Metabolism of steroids 0.5212468817292756 1.5787696163662146 0.1143889101273107 1.0 0.818023356901214 43 Q53GQ0,P04062,O95772,O14975,P30536,Q8NBQ5,O75845,Q15392,Q16850,Q99538,Q14739,Q9H2C2,P48449,Q9BWD1,Q9UBM7,Q9HCL2 16 +Dap12 interactions 0.7427977440606698 1.5779700347626051 0.114572493998968 1.0 0.818023356901214 5 P01889,P10321 2 +Complex i biogenesis 0.5392748313846109 1.567955157092913 0.1168915979855182 1.0 0.818023356901214 21 O96000,O75306,O43676,Q9NPL8 4 +Cs ds degradation 0.9572293716881142 1.562084850936088 0.1182680011726575 1.0 0.818023356901214 2 P06865 1 +Rhoq gtpase cycle 0.5358902630863774 1.554636949567909 0.1200325585803987 1.0 0.818023356901214 18 Q8TAA9,P02786,P27105 3 +Amyloid fiber formation 0.7366296084004393 1.5516044418724413 0.1207568996841441 1.0 0.818023356901214 5 P05067 1 +Rac3 gtpase cycle 0.5320698155173026 1.5270769170062866 0.1267418860646432 1.0 0.818023356901214 29 Q8TAA9,Q14126,Q9UQB8,P50402,P02786,O15173,Q15758,Q14739,Q7L576,Q9H0H5 10 +Phase i functionalization of compounds 0.5773093228020652 1.518740184023117 0.1288279075412066 1.0 0.818023356901214 12 Q5VT66,P07099,O43169,Q16850,P16435,Q15185 6 +Nrif signals cell death from the nucleus 0.9458743376230128 1.5155765309989386 0.1296264651477983 1.0 0.818023356901214 2 Q92542 1 +Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane 0.7233800682076577 1.494820628985865 0.1349612610246295 1.0 0.818023356901214 5 P12235,Q99808,P05141,P12236 4 +Death receptor signalling 0.5267328492045191 1.492323531389569 0.1356143507748222 1.0 0.818023356901214 19 Q8TCT8,Q92542 2 +Synthesis of pg 0.9375473126419368 1.481475993437278 0.1384797774611024 1.0 0.818023356901214 2 Q8IV08 1 +Amino acid transport across the plasma membrane 0.8258235516849728 1.454111462954654 0.1459154060168814 1.0 0.818023356901214 3 Q96QD8,P08195 2 +Metabolism of lipids 0.4846008163151739 1.4325131156200193 0.1519970272890825 1.0 0.818023356901214 157 Q13510,P48163,Q16836,Q9H7Z7,P30536,P50897,Q9UMR5,P06280,Q8NBQ5,P07602,Q16850,Q99538,P09960,Q96G23,Q9HCL2,P06865,P35790,Q10713,P16278,Q8N2A8,O14975,O15269,O75845,Q14739,Q16739,Q6P1A2,P48449,Q8IV08,Q9UBM7,Q9BWD1,O95470,P04062,Q96N66,P10619,Q8NCC3,O43681,Q15392,Q9H2C2,Q9Y305,O43772,P51648,P17900,Q53GQ0,P23786,O95772,Q9Y5P4,Q15067,Q06136,P07686,Q9NQZ5 50 +Signaling by insulin receptor 0.5292865592274427 1.413408055420737 0.1575357784363875 1.0 0.818023356901214 16 Q93050,Q9Y487 2 +Regulation of signaling by cbl 0.7330170409397507 1.3855877634711848 0.1658728167927909 1.0 0.818023356901214 4 P46108 1 +Bile acid and bile salt metabolism 0.6966474649975631 1.379717810807508 0.1676735468339676 1.0 0.818023356901214 5 O14975 1 +Synthesis of bile acids and bile salts 0.6966474649975631 1.379717810807508 0.1676735468339676 1.0 0.818023356901214 5 O14975 1 +Response to elevated platelet cytosolic ca2 0.5085906063369878 1.3765569602860392 0.168649265329126 1.0 0.818023356901214 32 Q9NTK5,Q06481,O94919,P07602,P05067,O43852,Q9NUQ9,Q9UHQ9,Q9NZJ7,Q08380,Q8NBX0 11 +Rhog gtpase cycle 0.5076489935470605 1.3698936194793805 0.1707201117423979 1.0 0.818023356901214 32 Q14126,P50402,P02786,O15173,Q14739,Q86XL3 6 +Formation of fibrin clot clotting cascade 0.909538228614684 1.3669174264884043 0.1716511891092991 1.0 0.818023356901214 2 P42785 1 +Intrinsic pathway of fibrin clot formation 0.909538228614684 1.3669174264884043 0.1716511891092991 1.0 0.818023356901214 2 P42785 1 +Degradation of the extracellular matrix 0.6564889975788791 1.353131697869474 0.1760135607752659 1.0 0.818023356901214 7 Q92542,P07858 2 +Cell death signalling via nrage nrif and nade 0.603678528505434 1.3488996826445343 0.1773691901879088 1.0 0.818023356901214 9 Q92542 1 +Nr1h3 nr1h2 regulate gene expression linked to cholesterol transport and efflux 0.7979759710585463 1.3417024431316462 0.1796924945628357 1.0 0.818023356901214 3 Q8NB78 1 +Met receptor recycling 0.7951430028334667 1.330272334027157 0.1834285590894833 1.0 0.818023356901214 3 P46108 1 +Antigen presentation folding assembly and peptide loading of class i mhc 0.5291510112242446 1.3222977585701026 0.1860690188655496 1.0 0.818023356901214 14 P04439,P01889,P10321 3 +Proton coupled monocarboxylate transport 0.8978046934140798 1.3190485776327447 0.187152872761434 1.0 0.818023356901214 2 P35613 1 +Interferon alpha beta signaling 0.597100787025226 1.3153629077609603 0.1883879652682745 1.0 0.818023356901214 9 P01889,P10321 2 +Eph ephrin mediated repulsion of cells 0.6194761122286365 1.2984189277533904 0.1941434184775219 1.0 0.8318054670934867 8 Q92542 1 +Glycerophospholipid biosynthesis 0.4972735729012727 1.2851579318612558 0.1987371008414302 1.0 0.8345641815773452 28 P35790,Q92604,Q96N66,Q8N2A8,O15228,Q8NCC3,P40939,Q6P1A2,Q9NPH0,Q9NQZ5,Q8IV08,Q9HCL2 12 +Wax and plasmalogen biosynthesis 0.7828218393866644 1.280593069418744 0.2003366356038725 1.0 0.8345641815773452 3 O15228 1 +G alpha i signalling events 0.4943171036943136 1.2771995808089798 0.2015317949586774 1.0 0.8345641815773452 20 P10644,P07602,P05067,P30154,P04899 5 +Metabolism of fat soluble vitamins 0.7724346838318851 1.238770590774863 0.2154304680176717 1.0 0.8678935620751368 3 Q8TC12,Q6NUM9 2 +Ripk1 mediated regulated necrosis 0.5567683025081478 1.2246482495281727 0.2207077802731762 1.0 0.8784340317725485 10 O00560,O75955 2 +Adora2b mediated anti inflammatory cytokines production 0.6407327279328081 1.173237196783642 0.2407006994012746 1.0 0.9108168175955004 6 P10644,P04899 2 +Cytochrome p450 arranged by substrate type 0.858440575321722 1.159453495879567 0.2462713818395245 1.0 0.9152583717162706 2 Q16850 1 +Peroxisomal lipid metabolism 0.5419632879881424 1.144311679448842 0.2524944013330508 1.0 0.9152583717162706 10 Q15067,O14975 2 +Golgi associated vesicle biogenesis 0.4751815919419548 1.131305180219999 0.2579266647662821 1.0 0.9175207873487788 28 O75976,P11717,Q99523,P02786 4 +Diseases of metabolism 0.4690964527935037 1.0973747134621972 0.2724776225541145 1.0 0.9175207873487788 33 P10253,P16278,P10619,P08236,P15586,P07686,P54802,O43505,P06865 9 +Signalling to ras 0.8425435276305808 1.0956442169349447 0.2732345033903578 1.0 0.9175207873487788 2 P11233 1 +Transcriptional regulation by e2f6 0.6001189276279374 1.0926489105315282 0.2745479791837804 1.0 0.9175207873487788 7 Q15022,P45973,Q13185,Q99496 4 +Ubiquinol biosynthesis 0.8417865253595758 1.092617696827218 0.2745616894117073 1.0 0.9175207873487788 2 Q9NZJ6 1 +Rhoh gtpase cycle 0.4644076589850205 1.0844144682447818 0.2781810715855686 1.0 0.9175207873487788 19 Q8TAA9,P02786,P27105 3 +Heme degradation 0.7292583794863436 1.0660146190546285 0.2864170334596458 1.0 0.9175207873487788 3 P30519 1 +Retrograde transport at the trans golgi network 0.4987168482339923 1.0616979012672056 0.2883728524382243 1.0 0.9175207873487788 12 P11717 1 +Miro gtpase cycle 0.7267395231176306 1.056015059384508 0.2909613347566482 1.0 0.9175207873487788 3 O95140 1 +P75 ntr receptor mediated signalling 0.4903974076964781 1.0490075068163964 0.2941746634406716 1.0 0.9175207873487788 13 Q92542 1 +Transport of vitamins nucleosides and related molecules 0.5860485207386781 1.0274621629327398 0.3042028932858707 1.0 0.9175207873487788 7 P12235,Q8TB61,Q99808 3 +Synthesis of leukotrienes lt and eoxins ex 0.8251324753974247 1.026353826292853 0.3047248341441877 1.0 0.9175207873487788 2 P09960 1 +Pyruvate metabolism 0.4673731358218964 1.0239978550284188 0.305836288041839 1.0 0.9175207873487788 16 P48163,P11177,P35613,P53985,P21796 5 +Collagen formation 0.4917962666645802 1.0209666420585384 0.3072702433129211 1.0 0.9175207873487788 12 O75718,P07858,Q32P28 3 +Synthesis secretion and inactivation of glucose dependent insulinotropic polypeptide gip 0.8183194549583614 0.999440576639681 0.317581311740355 1.0 0.9175207873487788 2 P67812 1 +Synthesis secretion and deacylation of ghrelin 0.8183194549583614 0.999440576639681 0.317581311740355 1.0 0.9175207873487788 2 P67812 1 +Ion homeostasis 0.557050081049834 0.9944237947796526 0.3200165885117032 1.0 0.9175207873487788 8 P05026,P16615 2 +Aquaporin mediated transport 0.7111215977510228 0.994283688048439 0.3200847747979893 1.0 0.9175207873487788 3 P10644 1 +Transport and synthesis of paps 0.8156699470098372 0.9890081068418544 0.3226591752935084 1.0 0.9189660055827772 2 Q8TB61 1 +Cdc42 gtpase cycle 0.448135860555182 0.9425981710864448 0.3458864756757001 1.0 0.9303071122202282 27 P02786,Q14739,P27105,Q9UQB8 4 +Ra biosynthesis pathway 0.7997728993186966 0.9268504921983256 0.3540041649091141 1.0 0.9330845234129496 2 Q8NBN7 1 +Diseases associated with n glycosylation of proteins 0.6108001103035432 0.8757734640977306 0.3811531985786391 1.0 0.9597657764893058 4 Q9BV10,Q9BT22 2 +Collagen biosynthesis and modifying enzymes 0.5107211484297273 0.8716969769997492 0.3833737098635121 1.0 0.9597657764893058 9 O75718,Q32P28 2 +Synthesis of substrates in n glycan biosythesis 0.488582354956628 0.853820574058168 0.3932044130138434 1.0 0.9668960975750248 10 P16278 1 +Antigen processing cross presentation 0.4147029520498735 0.8258878657630182 0.4088677045405648 1.0 0.9834955945214416 50 P20618,P01889,Q9UIQ6,P04439,P49720,P49721,P10321,P28070 8 +Phospholipid metabolism 0.4260845650885084 0.8095970513443422 0.4181718033566068 1.0 0.9893923435365792 40 P35790,Q92604,Q10713,Q96N66,Q8N2A8,O15228,Q8NCC3,P40939,Q6P1A2,Q9NPH0,Q9NQZ5,Q8IV08,Q9HCL2 13 +G alpha s signalling events 0.5908720140677411 0.795129746872544 0.4265380325468808 1.0 0.9893923435365792 4 P04899 1 +Metabolism of carbohydrates 0.3577180283761983 0.7862873867241036 0.4316991402815862 1.0 0.994528736143586 89 P10253,P16278,O00462,P08236,P15586,P07686,P54802,O00754,O43505,P06865 10 +Interferon gamma signaling 0.4562268970916593 0.7811153710005627 0.4347346422157114 1.0 0.9964206570309176 11 P01889,P10321 2 +Gamma carboxylation hypusine formation and arylsulfatase activation 0.4734736386852239 0.7720240892836665 0.4401001601381571 1.0 1.0 10 Q9HA64,O60725 2 +Degradation of cysteine and homocysteine 0.5751317723565721 0.7324717257541685 0.4638806940999354 1.0 1.0 4 Q9UBX3 1 +Rnd1 gtpase cycle 0.442346512278377 0.7304073419209315 0.4651412319121688 1.0 1.0 12 Q8TAA9,O75976,Q9NNW5,P02786,P38159,Q14254 6 +Sulfur amino acid metabolism 0.4829648789712949 0.7301402738680487 0.4653044459139952 1.0 1.0 9 Q13126,Q9UBX3,Q9BV57 3 +Selective autophagy 0.4163944879158111 0.7148195186164257 0.4747205726870336 1.0 1.0 29 Q13501,P21796,Q9NS69 3 +Regulated necrosis 0.4210997902647305 0.6963445188383427 0.4862130993417304 1.0 1.0 15 O00560,O75955 2 +Apoptotic cleavage of cell adhesion proteins 0.5367451636775518 0.6946292609350417 0.4872876698207182 1.0 1.0 5 Q16625 1 +Beta oxidation of butanoyl coa to acetyl coa 0.6248126601751154 0.6667376680688674 0.504939713654823 1.0 1.0 3 Q16836 1 +Biosynthesis of the n glycan precursor dolichol lipid linked oligosaccharide llo and transfer to a nascent protein 0.4264258548791746 0.6664536128170764 0.505121204014825 1.0 1.0 13 P16278 1 +Cytosolic sulfonation of small molecules 0.5571832926341947 0.6624117460410625 0.5077073779358752 1.0 1.0 4 Q8TB61 1 +Signalling to erks 0.505770925980401 0.6602577750621729 0.5090884220414704 1.0 1.0 7 P11233,P46108 2 +E2f mediated regulation of dna replication 0.4500314925811465 0.6463547802984544 0.5180496185079027 1.0 1.0 10 Q9Y619 1 +Diseases associated with glycosylation precursor biosynthesis 0.500613151572368 0.6372747992108232 0.5239458630192906 1.0 1.0 7 P16278 1 +Nr1h2 and nr1h3 mediated signaling 0.5153586263872849 0.6076332574612471 0.5434307381181218 1.0 1.0 5 Q8NB78 1 +Transcriptional activation of mitochondrial biogenesis 0.4416461534628152 0.6019429377638008 0.5472121214465058 1.0 1.0 10 P00367,P48735 2 +Negative regulation of nmda receptor mediated neuronal transmission 0.513339715373387 0.5995455785033704 0.548809125625302 1.0 1.0 5 Q14012 1 +Methionine salvage pathway 0.605658076027423 0.5988484410432918 0.5492739560747193 1.0 1.0 3 Q13126 1 +Abc transporters in lipid homeostasis 0.7074186222558628 0.587557042171198 0.5568296521977689 1.0 1.0 2 P28288 1 +Aflatoxin activation and detoxification 0.6020877250850809 0.5864584695693604 0.5575674623484503 1.0 1.0 3 Q99735 1 +Non integrin membrane ecm interactions 0.5363636363636459 0.5834084669765693 0.5596183593351314 1.0 1.0 4 P12814,P05556,Q9Y296 3 +Syndecan interactions 0.5363636363636459 0.5834084669765693 0.5596183593351314 1.0 1.0 4 P12814,P05556,Q9Y296 3 +Fgfr2 alternative splicing 0.4173316050025243 0.560214533725413 0.5753331148417424 1.0 1.0 11 P31943,P52597 2 +Small interfering rna sirna biogenesis 0.5938633876426668 0.5582614346709197 0.5766658753300884 1.0 1.0 3 O75569 1 +Regulation of mecp2 expression and activity 0.4975301880236802 0.5535866386186025 0.5798617722915904 1.0 1.0 6 Q14739 1 +Maturation of sars cov 2 nucleoprotein 0.5268939393939456 0.5484195986640353 0.5834038222229712 1.0 1.0 4 P48729,P49841,Q99873 3 +Inositol phosphate metabolism 0.5257575757575829 0.5442647380568144 0.5862593084615626 1.0 1.0 4 Q01968,Q9UNW1,P19174 3 +Leishmania infection 0.392065768786626 0.5357290765979802 0.5921458050836059 1.0 1.0 32 P62993,P46108,Q9UQB8,P10644,P05067,P04899,Q7L576 7 +Ire1alpha activates chaperones 0.3839917329303957 0.5341588997416625 0.5932316021048787 1.0 1.0 21 P43307,O14773 2 +Glyoxylate metabolism and glycine degradation 0.4286883679572024 0.5340743738645878 0.5932900786702093 1.0 1.0 10 Q9NR77 1 +Rhod gtpase cycle 0.3875568140337265 0.5303050189940883 0.5959004674067954 1.0 1.0 25 Q8TAA9,P50402,O15173,Q14739,Q9Y6M7,Q9H0H5 6 +Hiv transcription initiation 0.4917170554341428 0.5298411259349797 0.5962220884472409 1.0 1.0 6 Q92804 1 +Reduction of cytosolic ca levels 0.6884935654806921 0.5245886897994385 0.5998691508873031 1.0 1.0 2 P16615 1 +Platelet calcium homeostasis 0.6884935654806921 0.5245886897994385 0.5998691508873031 1.0 1.0 2 P16615 1 +The citric acid tca cycle and respiratory electron transport 0.3246615332590394 0.5022480228588329 0.6154930662459863 1.0 1.0 81 O96000,P48163,O14949,P24539,O75306,O43676,Q9UDW1,P35613,P11177,Q13423,P53985,P21796,Q9NPL8,P48735,O75964 15 +Signaling by hippo 0.507575757575768 0.479177949089816 0.631812039982629 1.0 1.0 4 Q07157,P62258,Q4VCS5 3 +Respiratory electron transport 0.3819029352729048 0.4710485579158233 0.637606059384151 1.0 1.0 41 O96000,O14949,O43819,Q9UDW1,O43674,O75306,P00403,O43676,Q9NPL8,P20674 10 +Deubiquitination 0.3240531879488501 0.4677553204630912 0.6399595752280622 1.0 1.0 83 P20618,P45880,O95630,Q96FW1,P21796,P49720,P49721,P28070,Q8NB78,Q9Y277 10 +Protein protein interactions at synapses 0.3999069052902713 0.4639596590292504 0.6426766484061357 1.0 1.0 11 O75955,O95197 2 +Ret signaling 0.5012612372020697 0.4572320864959188 0.6475042378723512 1.0 1.0 4 Q9NR12 1 +Cardiac conduction 0.4274708639919042 0.4563420428027548 0.6481440355290675 1.0 1.0 9 P05026,P16615 2 +Akt phosphorylates targets in the cytosol 0.5611510791366823 0.4514131728191728 0.6516917910351783 1.0 1.0 3 P49841,P31751 2 +Mhc class ii antigen presentation 0.3690181511923185 0.4458502466453816 0.655705423456566 1.0 1.0 51 P10619,Q99538,P07858 3 +Alpha oxidation of phytanate 0.4731333266901395 0.4441972812426541 0.6568999577173069 1.0 1.0 5 O14975 1 +Ub specific processing proteases 0.3297108781982189 0.4264360759536911 0.6697901184874266 1.0 1.0 68 P20618,P45880,Q96FW1,P21796,P49720,P49721,P28070,Q9Y277 8 +Interleukin 1 signaling 0.3712436075051349 0.4234376848236365 0.6719759548262445 1.0 1.0 47 P20618,P05067,Q13501,P49720,P49721,P28070 6 +Constitutive signaling by akt1 e17k in cancer 0.4912878787878846 0.4233283439252633 0.6720557172543851 1.0 1.0 4 O15111,P49841,P31751 3 +Beta oxidation of lauroyl coa to decanoyl coa coa 0.4909530562384741 0.4222069402773566 0.6728739761635518 1.0 1.0 4 Q16836 1 +Beta oxidation of hexanoyl coa to butanoyl coa 0.4909530562384741 0.4222069402773566 0.6728739761635518 1.0 1.0 4 Q16836 1 +Constitutive signaling by ligand responsive egfr cancer variants 0.462296324365299 0.4045566538180578 0.6858034260093309 1.0 1.0 5 P62993,P22681,Q16543,P19174 4 +Signaling by egfr in cancer 0.462296324365299 0.4045566538180578 0.6858034260093309 1.0 1.0 5 P62993,P22681,Q16543,P19174 4 +Constitutive signaling by egfrviii 0.462296324365299 0.4045566538180578 0.6858034260093309 1.0 1.0 5 P62993,P22681,Q16543,P19174 4 +Signaling by erbb4 0.4597757784212647 0.395496505965269 0.6924764997289987 1.0 1.0 5 Q92542 1 +Interleukin 3 interleukin 5 and gm csf signaling 0.4571318453312559 0.3934315147674547 0.6940007970540811 1.0 1.0 6 P46108 1 +Inla mediated entry of listeria monocytogenes into host cells 0.6434519303557852 0.3874463365642969 0.6984258056387047 1.0 1.0 2 O60716 1 +Regulation of lipid metabolism by pparalpha 0.3609411680331421 0.3848021909720495 0.7003839757325621 1.0 1.0 17 P23786,Q15067 2 +Cellular response to hypoxia 0.3673501293009263 0.359166323524785 0.7194706680068601 1.0 1.0 41 Q9NWT6,P20618,P49720,P49721,P28070 5 +Pyruvate metabolism and citric acid tca cycle 0.3657020962849615 0.348978599549801 0.7271053758658073 1.0 1.0 32 P48163,Q13423,P11177,P35613,P53985,P21796,P48735 7 +E3 ubiquitin ligases ubiquitinate target proteins 0.3699791343341203 0.342863551296142 0.7317011133528373 1.0 1.0 13 P04439 1 +Interleukin 1 family signaling 0.3592741378157935 0.3420696883297343 0.7322984481714001 1.0 1.0 49 P20618,P05067,Q13501,P49720,P49721,P28070 6 +Activation of gene expression by srebf srebp 0.3535624966552966 0.340050727472398 0.7338183267004286 1.0 1.0 17 O75845,Q16850,P48449,Q9UBM7,Q9HCL2 5 +Signaling by erbb2 ecd mutants 0.462121212121224 0.3301343681730759 0.7412984355965495 1.0 1.0 4 P62993,Q16543,P19174 3 +Signaling by erbb2 in cancer 0.462121212121224 0.3301343681730759 0.7412984355965495 1.0 1.0 4 P62993,Q16543,P19174 3 +Fatty acyl coa biosynthesis 0.3630575923587914 0.3255017529439514 0.7448013561408138 1.0 1.0 14 P50897 1 +Beta oxidation of pristanoyl coa 0.5164710336993467 0.3220276907058258 0.7474317168345839 1.0 1.0 3 P51659,O15254 2 +Biological oxidations 0.3629467647029662 0.3219828678519327 0.7474656734294762 1.0 1.0 39 O14880,Q8TB61,P21964,O43169,Q16850,Q99735,Q5VT66,Q9NUJ1 8 +Cristae formation 0.3504179030304706 0.3174716956216134 0.7508857131203355 1.0 1.0 21 P17152,Q9BUR5,Q5XKP0,Q13505,O75964 5 +Phosphorylation of the apc c 0.3842065299924148 0.3114919967647483 0.7554266261393936 1.0 1.0 10 P53350,Q9UJX2,Q9UJX3,P06493,Q9UM13,Q9UJX4,Q9H1A4,Q16763,P30260 9 +Aryl hydrocarbon receptor signalling 0.5114691905492036 0.3089243032134224 0.7573791091396349 1.0 1.0 3 Q15185 1 +Innate immune system 0.4570551660252978 0.2990386786637017 0.7649105337446809 1.0 1.0 259 Q13510,P07858,O00584,P06280,P07602,P05067,Q99538,P15586,O15260,O75874,Q9BTY2,P11717,Q9NQX7,P20618,P16278,P01889,O14975,O75787,O00462,P61916,P27105,P04439,P49721,Q93050,Q8IV08,P30519,P10619,O00560,Q92820,P42785,P04066,P53634,P10321,P28070,P49720,P17900,P10253,P11279,Q9Y487,Q9UQB8,P61225,P08236,O00264,P07686,Q92542,O00754 46 +Anti inflammatory response favouring leishmania parasite infection 0.3872438131171356 0.2732563206651984 0.7846561890403441 1.0 1.0 9 P10644,P04899 2 +Initiation of nuclear envelope ne reformation 0.3409757954075889 0.2653952549319334 0.790704991161989 1.0 1.0 17 Q14739,Q86XL3 2 +Translation of sars cov 1 structural proteins 0.4181197877179837 0.2527447821045225 0.8004654399495637 1.0 1.0 6 Q10472,P49841,Q14697,P27824,P14314 5 +Transcriptional regulation by ventx 0.3592859855678018 0.2514058697850638 0.8015003299847636 1.0 1.0 11 Q9UJX2,Q9UJX3,Q9HCE1,P35222,Q9UM13,P04637,Q9UJX4,Q9H1A4,Q16763,P30260 10 +Metabolism of porphyrins 0.4060246185547161 0.2485838552287995 0.8036826982169281 1.0 1.0 7 P30519,P36551 2 +Defective intrinsic pathway for apoptosis 0.3489368162225149 0.2483997794707679 0.8038251041916893 1.0 1.0 14 P05067 1 +Hemostasis 0.3296388276789813 0.2385258241316409 0.811473288502506 1.0 1.0 106 Q9NTK5,P07602,P05067,P53985,O43852,P08195,Q8N2K0,Q08380,P62993,P14174,P46108,O94919,P10644,Q02241,P16615,P05026,Q06481,Q9H4M9,Q92896,P35613,P42785,Q9NUQ9,Q9UHQ9,Q8NBX0,O00186,Q9UIJ7,Q07021,P78310,P30154,O95140,P04899,Q9NZJ7,Q9H0H5 33 +Cargo recognition for clathrin mediated endocytosis 0.3445631849454083 0.2199804346888643 0.825886392347762 1.0 1.0 29 P02786,P11717,Q14108,P51809 4 +Maturation of sars cov 1 spike protein 0.4178030303030339 0.2086806783782839 0.8346975244873966 1.0 1.0 4 P27824,P14314,Q14697 3 +Unfolded protein response upr 0.3459340473225163 0.2064820761975139 0.8364143642037636 1.0 1.0 34 Q9NWM8,P05198,Q92945,P43307,O14773,Q9Y5M8 6 +Signaling by flt3 fusion proteins 0.4665336719990307 0.2053309679978517 0.8373135505150298 1.0 1.0 3 P62993 1 +Irak1 recruits ikk complex 0.5609386828160411 0.1946477043005137 0.845668754623587 1.0 1.0 2 P61088 1 +Ticam1 rip1 mediated ikk complex recruitment 0.5609386828160411 0.1946477043005137 0.845668754623587 1.0 1.0 2 P61088 1 +Ikk complex recruitment mediated by rip1 0.5609386828160411 0.1946477043005137 0.845668754623587 1.0 1.0 2 P61088 1 +Synthesis of pa 0.3767948486427896 0.1825634976297206 0.8551405275922264 1.0 1.0 8 Q9HCL2,Q8N2A8,Q9NPH0 3 +Mitochondrial biogenesis 0.3404803462204521 0.1825243143331059 0.8551712747653075 1.0 1.0 31 P17152,P24539,Q9BUR5,Q5XKP0,Q13505,P48735,O75964 7 +Rac1 gtpase cycle 0.3410641573487597 0.1772989822497382 0.8592735501775841 1.0 1.0 33 Q8TAA9,Q9UQB8,P50402,P02786,Q15758,Q14739,Q7L576,Q9H0H5 8 +Visual phototransduction 0.4029790615082257 0.1742631034883297 0.861658694685338 1.0 1.0 4 Q8TC12,Q6NUM9 2 +Regulation of insulin secretion 0.3621329949499124 0.1697115030400936 0.8652370271911916 1.0 1.0 9 P04899 1 +Disorders of transmembrane transporters 0.294807297564465 0.1694058755542669 0.8654774022774594 1.0 1.0 72 Q92530,P28074,P28072,P20618,Q99436,P60900,Q7Z3B4,P35613,O75477,P53985,Q9BTX1,P08195,P49721,P49720,P28070,Q9BUN8,Q8TEM1 17 +Josephin domain dubs 0.4460431654676242 0.1670082888609803 0.867363526957764 1.0 1.0 3 P54725,P54727 2 +Activation of nima kinases nek9 nek6 nek7 0.3834785903751463 0.1572853994010093 0.8750199266277854 1.0 1.0 5 P53350,O95067,Q8TD19,P06493 4 +Perk regulates gene expression 0.3390026421304303 0.1543435822578193 0.8773388353208138 1.0 1.0 11 Q92945 1 +Synthesis of ip3 and ip4 in the cytosol 0.5344436033308019 0.1509776155874637 0.8799933736464327 1.0 1.0 2 Q01968 1 +Synthesis of ip2 ip and ins in the cytosol 0.5253595760787202 0.1380679357261275 0.8901867266213634 1.0 1.0 2 Q01968 1 +G2 m dna replication checkpoint 0.3833333333333398 0.1338173867844724 0.8935469781881245 1.0 1.0 4 Q99640,O95067,P06493 3 +Regulation of beta cell development 0.5147615442846278 0.1243015447745965 0.9010765242353992 1.0 1.0 2 P31751 1 +Transcriptional regulation by mecp2 0.358484128219185 0.1183854271457605 0.9057622720295784 1.0 1.0 8 Q14739 1 +Rap1 signalling 0.5071915215745555 0.1153009453646119 0.9082065890687644 1.0 1.0 2 P63104 1 +Interleukin 23 signaling 0.5030280090840235 0.1106390117546098 0.9119026104737704 1.0 1.0 2 P07237 1 +Transcriptional regulation of pluripotent stem cells 0.5030280090840172 0.1106390117546028 0.911902610473776 1.0 1.0 2 Q99626 1 +Abc transporter disorders 0.3334326062296517 0.1088451729236612 0.9133252938262602 1.0 1.0 42 Q92530,P28074,P28072,P20618,Q99436,O75477,P49720,P49721,P28070,Q9BUN8 10 +Defective cftr causes cystic fibrosis 0.3334326062296515 0.1088451729236601 0.913325293826261 1.0 1.0 42 Q92530,P28074,P28072,P20618,Q99436,O75477,P49720,P49721,P28070,Q9BUN8 10 +Notch1 intracellular domain regulates transcription 0.3678030303030347 0.1060918756001475 0.915509457098504 1.0 1.0 4 Q13616,Q13573,P63208 3 +Cdt1 association with the cdc6 orc origin complex 0.3318544867003383 0.1004484428920902 0.9199883123436852 1.0 1.0 38 P20618,P49720,P49721,Q9Y619,P28070 5 +Cd28 dependent pi3k akt signaling 0.4909159727479117 0.0982041022746648 0.9217702250683182 1.0 1.0 2 P31751 1 +Platelet aggregation plug formation 0.352021672856004 0.0840647334725821 0.9330049639710232 1.0 1.0 5 P62993,P46108 2 +Integrin signaling 0.352021672856004 0.0840647334725821 0.9330049639710232 1.0 1.0 5 P62993,P46108 2 +Regulation of tp53 activity through methylation 0.4477668433005184 0.066184371165247 0.9472310394940426 1.0 1.0 2 O14744 1 +Diseases of immune system 0.358197652404381 0.0649190675688206 0.9482384388928348 1.0 1.0 3 O15111,P09429 2 +Vitamin c ascorbate metabolism 0.4447388342164911 0.0645692127619832 0.9485169981951044 1.0 1.0 2 P00387 1 +Interleukin 12 signaling 0.3167260017013406 0.0618425688336454 0.9506882033171352 1.0 1.0 27 O14979,P11233,Q13126,P52597,P51809 5 +Signaling by notch4 0.3259021864290273 0.0554330885434636 0.9557934355085004 1.0 1.0 42 P20618,P49720,P49721,P28070,Q92542 5 +Fbxw7 mutants and notch1 in cancer 0.4152157456472306 0.0523017955972234 0.9582882225974324 1.0 1.0 2 P63208 1 +Regulation of cytoskeletal remodeling and cell spreading by ipp complex components 0.4137017411052132 0.0518235563643937 0.9586692855041974 1.0 1.0 2 P12814 1 +Transcription of e2f targets under negative control by p107 rbl1 and p130 rbl2 in complex with hdac1 0.4046177138531368 0.0492174938522055 0.9607459700831128 1.0 1.0 2 Q09028 1 +Camk iv mediated phosphorylation of creb 0.4012112036336051 0.0483498185777411 0.961437451467702 1.0 1.0 2 Q13555 1 +Creb1 phosphorylation through the activation of camkii camkk camkiv cascasde 0.4012112036336051 0.0483498185777411 0.961437451467702 1.0 1.0 2 Q13555 1 +Darpp 32 events 0.3417163920467821 0.046855106527804 0.9626287085685532 1.0 1.0 7 P10644 1 +Sumoylation of dna methylation proteins 0.3195759182127997 0.0461556721738887 0.9631861732746848 1.0 1.0 3 Q14781,Q99496 2 +Prevention of phagosomal lysosomal fusion 0.3174242424242459 0.0412372888986187 0.9671067267011282 1.0 1.0 4 P51149,Q9H267,P20339 3 +Rab gefs exchange gtp for gdp on rabs 0.306371613887826 0.0386944498791575 0.9691339984520284 1.0 1.0 23 Q9Y296,P51153,P61106,Q9UL25,P61020,Q7Z392,P50395,P61006,Q15286,Q9H2M9,P62820,P31150,P20339,P62258,P31751,Q9NP72,O43617,P61026,Q8IUR0,Q14C86,P51149,P51148 22 +Inlb mediated entry of listeria monocytogenes into host cell 0.3258810155361893 0.035956359878403 0.9713171562061708 1.0 1.0 5 P62993,P22681,Q92783,P42566 4 +Signaling by retinoic acid 0.3311646022983566 0.0342047055363691 0.9727139142628044 1.0 1.0 8 P11177,Q8NBN7 2 +Abc family proteins mediated transport 0.320876556597589 0.0339490813166406 0.972917754493002 1.0 1.0 49 Q92530,P28072,P20618,Q99436,O75477,P05198,P49720,P49721,P28070,P08183,Q9BUN8 11 +Autophagy 0.3224272585057891 0.031907719597936 0.9745456424267936 1.0 1.0 41 Q13501,P21796,Q9NS69 3 +Cell extracellular matrix interactions 0.3205759757483932 0.027612765746291 0.977970999955172 1.0 1.0 5 P12814,P05556,Q14315,Q15404 4 +Signaling by fgfr2 0.2949049988141246 0.0180802290292396 0.9855748503235237 1.0 1.0 17 P31943,Q01085,P52597 3 +Signaling by fgfr 0.2949049988141244 0.0180802290292387 0.9855748503235242 1.0 1.0 17 P31943,Q01085,P52597 3 +Miscellaneous transport and binding events 0.2818181818181839 0.015660185642407 0.9875054903539068 1.0 1.0 4 Q8N4V1,Q9UEY8,P35611 3 +Listeria monocytogenes entry into host cells 0.3261281759575288 0.0090590126274858 0.9927720525496524 1.0 1.0 7 P62993,P22681,O60716,P35222,Q92783,P42566 6 diff --git a/msigdb_reactome/selections.json b/msigdb_reactome/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..bfc29896d4cd421eed7424c0be06874ac48cde80 --- /dev/null +++ b/msigdb_reactome/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["2 ltr circle formation", "Abacavir metabolism", "Abacavir transmembrane transport", "Abacavir transport and metabolism", "Abc family proteins mediated transport", "Abc transporter disorders", "Abc transporters in lipid homeostasis", "Aberrant regulation of mitotic exit in cancer due to rb1 defects", "Aberrant regulation of mitotic g1 s transition in cancer due to rb1 defects", "Abortive elongation of hiv 1 transcript in the absence of tat", "Acetylcholine neurotransmitter release cycle", "Acetylcholine regulates insulin secretion", "Activated notch1 transmits signal to the nucleus", "Activated ntrk2 signals through cdk5", "Activated ntrk2 signals through frs2 and frs3", "Activated ntrk2 signals through fyn", "Activated ntrk2 signals through pi3k", "Activated ntrk2 signals through ras", "Activated ntrk3 signals through ras", "Activated pkn1 stimulates transcription of ar androgen receptor regulated genes klk2 and klk3", "Activated tak1 mediates p38 mapk activation", "Activation of ampk downstream of nmdars", "Activation of anterior hox genes in hindbrain development during early embryogenesis", "Activation of atr in response to replication stress", "Activation of bad and translocation to mitochondria", "Activation of bh3 only proteins", "Activation of gene expression by srebf srebp", "Activation of irf3 irf7 mediated by tbk1 ikk epsilon", "Activation of kainate receptors upon glutamate binding", "Activation of nima kinases nek9 nek6 nek7", "Activation of nmda receptors and postsynaptic events", "Activation of noxa and translocation to mitochondria", "Activation of ppargc1a pgc 1alpha by phosphorylation", "Activation of puma and translocation to mitochondria", "Activation of rac1", "Activation of rac1 downstream of nmdars", "Activation of smo", "Activation of the ap 1 family of transcription factors", "Activation of the mrna upon binding of the cap binding complex and eifs and subsequent binding to 43s", "Activation of the pre replicative complex", "Acyl chain remodeling of cl", "Acyl chain remodelling of pc", "Acyl chain remodelling of pe", "Acyl chain remodelling of pg", "Acyl chain remodelling of pi", "Acyl chain remodelling of ps", "Adaptive immune system", "Adenylate cyclase inhibitory pathway", "Adherens junctions interactions", "Adora2b mediated anti inflammatory cytokines production", "Adp signalling through p2y purinoceptor 12", "Adrenaline noradrenaline inhibits insulin secretion", "Advanced glycosylation endproduct receptor signaling", "Aflatoxin activation and detoxification", "Aggrephagy", "Akt phosphorylates targets in the cytosol", "Akt phosphorylates targets in the nucleus", "Alk mutants bind tkis", "Alpha linolenic omega3 and linoleic omega6 acid metabolism", "Alpha oxidation of phytanate", "Amino acid transport across the plasma membrane", "Amino acids regulate mtorc1", "Amyloid fiber formation", "Anchoring of the basal body to the plasma membrane", "Androgen biosynthesis", "Anti inflammatory response favouring leishmania parasite infection", "Antigen activates b cell receptor bcr leading to generation of second messengers", "Antigen presentation folding assembly and peptide loading of class i mhc", "Antigen processing cross presentation", "Antigen processing ubiquitination proteasome degradation", "Antimicrobial peptides", "Antiviral mechanism by ifn stimulated genes", "Apc c cdc20 mediated degradation of cyclin b", "Apc c cdh1 mediated degradation of cdc20 and other apc c cdh1 targeted proteins in late mitosis early g1", "Apc c mediated degradation of cell cycle proteins", "Apc cdc20 mediated degradation of nek2a", "Apex1 independent resolution of ap sites via the single nucleotide replacement pathway", "Apobec3g mediated resistance to hiv 1 infection", "Apoptosis", "Apoptosis induced dna fragmentation", "Apoptotic cleavage of cell adhesion proteins", "Apoptotic cleavage of cellular proteins", "Apoptotic execution phase", "Apoptotic factor mediated response", "Aquaporin mediated transport", "Arachidonate production from dag", "Arachidonic acid metabolism", "Arms mediated activation", "Aryl hydrocarbon receptor signalling", "Asparagine n linked glycosylation", "Aspartate and asparagine metabolism", "Assembly and cell surface presentation of nmda receptors", "Assembly of collagen fibrils and other multimeric structures", "Assembly of the hiv virion", "Assembly of the orc complex at the origin of replication", "Association of tric cct with target proteins during biosynthesis", "Asymmetric localization of pcp proteins", "Atf4 activates genes in response to endoplasmic reticulum stress", "Atf6 atf6 alpha activates chaperone genes", "Atf6 atf6 alpha activates chaperones", "Attachment and entry", "Attachment of gpi anchor to upar", "Attenuation phase", "Auf1 hnrnp d0 binds and destabilizes mrna", "Aurka activation by tpx2", "Autophagy", "B wich complex positively regulates rrna expression", "Base excision repair", "Base excision repair ap site formation", "Basigin interactions", "Bbsome mediated cargo targeting to cilium", "Beta catenin independent wnt signaling", "Beta catenin phosphorylation cascade", "Beta oxidation of butanoyl coa to acetyl coa", "Beta oxidation of decanoyl coa to octanoyl coa coa", "Beta oxidation of hexanoyl coa to butanoyl coa", "Beta oxidation of lauroyl coa to decanoyl coa coa", "Beta oxidation of octanoyl coa to hexanoyl coa", "Beta oxidation of pristanoyl coa", "Beta oxidation of very long chain fatty acids", "Bh3 only proteins associate with and inactivate anti apoptotic bcl 2 members", "Bicarbonate transporters", "Bile acid and bile salt metabolism", "Binding and uptake of ligands by scavenger receptors", "Binding of tcf lef ctnnb1 to target gene promoters", "Biological oxidations", "Biosynthesis of epa derived spms", "Biosynthesis of maresins", "Biosynthesis of specialized proresolving mediators spms", "Biosynthesis of the n glycan precursor dolichol lipid linked oligosaccharide llo and transfer to a nascent protein", "Biotin transport and metabolism", "Bmal1 clock npas2 activates circadian gene expression", "Branched chain amino acid catabolism", "Budding and maturation of hiv virion", "Butyrate response factor 1 brf1 binds and destabilizes mrna", "C type lectin receptors clrs", "Ca dependent events", "Ca2 pathway", "Calcineurin activates nfat", "Calnexin calreticulin cycle", "Camk iv mediated phosphorylation of creb", "Carboxyterminal post translational modifications of tubulin", "Cardiac conduction", "Cargo concentration in the er", "Cargo recognition for clathrin mediated endocytosis", "Cargo trafficking to the periciliary membrane", "Carnitine metabolism", "Caspase activation via death receptors in the presence of ligand", "Caspase activation via extrinsic apoptotic signalling pathway", "Caspase mediated cleavage of cytoskeletal proteins", "Cation coupled chloride cotransporters", "Cd163 mediating an anti inflammatory response", "Cd209 dc sign signaling", "Cd28 co stimulation", "Cd28 dependent pi3k akt signaling", "Cd28 dependent vav1 pathway", "Cdc42 gtpase cycle", "Cdc6 association with the orc origin complex", "Cdt1 association with the cdc6 orc origin complex", "Cell cell communication", "Cell cell junction organization", "Cell cycle", "Cell cycle checkpoints", "Cell cycle mitotic", "Cell death signalling via nrage nrif and nade", "Cell extracellular matrix interactions", "Cell junction organization", "Cell surface interactions at the vascular wall", "Cellular response to chemical stress", "Cellular response to heat stress", "Cellular response to hypoxia", "Cellular response to starvation", "Cellular responses to stimuli", "Cellular senescence", "Chaperone mediated autophagy", "Chk1 chk2 cds1 mediated inactivation of cyclin b cdk1 complex", "Chl1 interactions", "Cholesterol biosynthesis", "Choline catabolism", "Chondroitin sulfate biosynthesis", "Chondroitin sulfate dermatan sulfate metabolism", "Chrebp activates metabolic gene expression", "Chromatin modifying enzymes", "Chromosome maintenance", "Chylomicron assembly", "Cilium assembly", "Circadian clock", "Citric acid cycle tca cycle", "Class a 1 rhodopsin like receptors", "Class b 2 secretin family receptors", "Class i mhc mediated antigen processing presentation", "Class i peroxisomal membrane protein import", "Clathrin mediated endocytosis", "Clec7a dectin 1 induces nfat activation", "Clec7a dectin 1 signaling", "Clec7a inflammasome pathway", "Cobalamin cbl vitamin b12 transport and metabolism", "Coenzyme a biosynthesis", "Cohesin loading onto chromatin", "Collagen biosynthesis and modifying enzymes", "Collagen degradation", "Collagen formation", "Competing endogenous rnas cernas regulate pten translation", "Complement cascade", "Complex i biogenesis", "Condensation of prometaphase chromosomes", "Condensation of prophase chromosomes", "Constitutive signaling by aberrant pi3k in cancer", "Constitutive signaling by akt1 e17k in cancer", "Constitutive signaling by egfrviii", "Constitutive signaling by ligand responsive egfr cancer variants", "Constitutive signaling by overexpressed erbb2", "Conversion from apc c cdc20 to apc c cdh1 in late anaphase", "Cooperation of pdcl phlp1 and tric cct in g protein beta folding", "Cooperation of prefoldin and tric cct in actin and tubulin folding", "Copi dependent golgi to er retrograde traffic", "Copi independent golgi to er retrograde traffic", "Copi mediated anterograde transport", "Copii mediated vesicle transport", "Costimulation by the cd28 family", "Creatine metabolism", "Creb phosphorylation", "Creb1 phosphorylation through nmda receptor mediated activation of ras signaling", "Creb1 phosphorylation through the activation of adenylate cyclase", "Creb1 phosphorylation through the activation of camkii camkk camkiv cascasde", "Cristae formation", "Crmps in sema3a signaling", "Cross presentation of soluble exogenous antigens endosomes", "Cs ds degradation", "Ctla4 inhibitory signaling", "Cyclin a b1 b2 associated events during g2 m transition", "Cyclin a cdk2 associated events at s phase entry", "Cyclin d associated events in g1", "Cytochrome c mediated apoptotic response", "Cytochrome p450 arranged by substrate type", "Cytokine signaling in immune system", "Cytoprotection by hmox1", "Cytosolic iron sulfur cluster assembly", "Cytosolic sensors of pathogen associated dna", "Cytosolic sulfonation of small molecules", "Cytosolic trna aminoacylation", "Dag and ip3 signaling", "Dap12 interactions", "Dap12 signaling", "Darpp 32 events", "Dcc mediated attractive signaling", "Ddx58 ifih1 mediated induction of interferon alpha beta", "Deactivation of the beta catenin transactivating complex", "Deadenylation dependent mrna decay", "Deadenylation of mrna", "Death receptor signalling", "Dectin 1 mediated noncanonical nf kb signaling", "Defective cftr causes cystic fibrosis", "Defective chst14 causes eds musculocontractural type", "Defective factor ix causes hemophilia b", "Defective intrinsic pathway for apoptosis", "Defective ripk1 mediated regulated necrosis", "Defects in biotin btn metabolism", "Defects in cobalamin b12 metabolism", "Defects in vitamin and cofactor metabolism", "Defects of contact activation system cas and kallikrein kinin system kks", "Degradation of axin", "Degradation of beta catenin by the destruction complex", "Degradation of cysteine and homocysteine", "Degradation of dvl", "Degradation of gli1 by the proteasome", "Degradation of the extracellular matrix", "Depolymerisation of the nuclear lamina", "Deposition of new cenpa containing nucleosomes at the centromere", "Dermatan sulfate biosynthesis", "Detoxification of reactive oxygen species", "Deubiquitination", "Developmental biology", "Dex h box helicases activate type i ifn and inflammatory cytokines production", "Digestion", "Digestion and absorption", "Disassembly of the destruction complex and recruitment of axin to the membrane", "Diseases associated with glycosaminoglycan metabolism", "Diseases associated with glycosylation precursor biosynthesis", "Diseases associated with n glycosylation of proteins", "Diseases associated with o glycosylation of proteins", "Diseases of base excision repair", "Diseases of carbohydrate metabolism", "Diseases of dna repair", "Diseases of glycosylation", "Diseases of immune system", "Diseases of metabolism", "Diseases of mismatch repair mmr", "Diseases of mitotic cell cycle", "Diseases of programmed cell death", "Diseases of signal transduction by growth factor receptors and second messengers", "Disinhibition of snare formation", "Disorders of transmembrane transporters", "Displacement of dna glycosylase by apex1", "Dissolution of fibrin clot", "Dna damage bypass", "Dna damage recognition in gg ner", "Dna damage reversal", "Dna damage telomere stress induced senescence", "Dna double strand break repair", "Dna double strand break response", "Dna methylation", "Dna repair", "Dna replication", "Dna replication initiation", "Dna replication pre initiation", "Dna strand elongation", "Dopamine clearance from the synaptic cleft", "Dopamine neurotransmitter release cycle", "Downregulation of erbb2 erbb3 signaling", "Downregulation of erbb2 signaling", "Downregulation of smad2 3 smad4 transcriptional activity", "Downregulation of tgf beta receptor signaling", "Downstream signal transduction", "Downstream signaling events of b cell receptor bcr", "Downstream signaling of activated fgfr1", "Downstream signaling of activated fgfr2", "Downstream signaling of activated fgfr3", "Downstream signaling of activated fgfr4", "Dscam interactions", "Dual incision in gg ner", "Dual incision in tc ner", "E2f enabled inhibition of pre replication complex formation", "E2f mediated regulation of dna replication", "E3 ubiquitin ligases ubiquitinate target proteins", "Early phase of hiv life cycle", "Ecm proteoglycans", "Effects of pip2 hydrolysis", "Egfr downregulation", "Egfr interacts with phospholipase c gamma", "Egfr transactivation by gastrin", "Egr2 and sox10 mediated initiation of schwann cell myelination", "Elastic fibre formation", "Endogenous sterols", "Endosomal sorting complex required for transport escrt", "Endosomal vacuolar pathway", "Energy dependent regulation of mtor by lkb1 ampk", "Enos activation", "Eph ephrin mediated repulsion of cells", "Eph ephrin signaling", "Epha mediated growth cone collapse", "Ephb mediated forward signaling", "Ephrin signaling", "Epigenetic regulation of gene expression", "Er quality control compartment erqc", "Er to golgi anterograde transport", "Erbb2 regulates cell motility", "Ercc6 csb and ehmt2 g9a positively regulate rrna expression", "Erk mapk targets", "Erks are inactivated", "Erythrocytes take up carbon dioxide and release oxygen", "Erythropoietin activates phospholipase c gamma plcg", "Erythropoietin activates ras", "Esr mediated signaling", "Establishment of sister chromatid cohesion", "Estrogen biosynthesis", "Estrogen dependent gene expression", "Estrogen dependent nuclear events downstream of esr membrane signaling", "Estrogen stimulated signaling through prkcz", "Ethanol oxidation", "Eukaryotic translation elongation", "Eukaryotic translation initiation", "Export of viral ribonucleoproteins from nucleus", "Extension of telomeres", "Extra nuclear estrogen signaling", "Extracellular matrix organization", "Factors involved in megakaryocyte development and platelet production", "Fanconi anemia pathway", "Fasl cd95l signaling", "Fatty acid metabolism", "Fatty acyl coa biosynthesis", "Fbxw7 mutants and notch1 in cancer", "Fc epsilon receptor fceri signaling", "Fceri mediated ca 2 mobilization", "Fceri mediated mapk activation", "Fceri mediated nf kb activation", "Fcgamma receptor fcgr dependent phagocytosis", "Fcgr3a mediated il10 synthesis", "Fgfr1 mutant receptor activation", "Fgfr2 alternative splicing", "Fgfr2 mutant receptor activation", "Fibronectin matrix formation", "Flt3 signaling", "Flt3 signaling by cbl mutants", "Flt3 signaling in disease", "Folding of actin by cct tric", "Formation of apoptosome", "Formation of atp by chemiosmotic coupling", "Formation of fibrin clot clotting cascade", "Formation of incision complex in gg ner", "Formation of rna pol ii elongation complex", "Formation of senescence associated heterochromatin foci sahf", "Formation of tc ner pre incision complex", "Formation of the beta catenin tcf transactivating complex", "Formation of the cornified envelope", "Formation of the early elongation complex", "Formation of tubulin folding intermediates by cct tric", "Formation of xylulose 5 phosphate", "Formyl peptide receptors bind formyl peptides and many other ligands", "Foxo mediated transcription", "Foxo mediated transcription of oxidative stress metabolic and neuronal genes", "Free fatty acids regulate insulin secretion", "Frs mediated fgfr1 signaling", "Frs mediated fgfr2 signaling", "Frs mediated fgfr3 signaling", "Frs mediated fgfr4 signaling", "Fructose metabolism", "G alpha 12 13 signalling events", "G alpha i signalling events", "G alpha q signalling events", "G alpha s signalling events", "G alpha z signalling events", "G beta gamma signalling through cdc42", "G beta gamma signalling through pi3kgamma", "G protein beta gamma signalling", "G protein mediated events", "G0 and early g1", "G1 s dna damage checkpoints", "G1 s specific transcription", "G2 m checkpoints", "G2 m dna damage checkpoint", "G2 m dna replication checkpoint", "G2 phase", "Gab1 signalosome", "Gaba b receptor activation", "Gaba receptor activation", "Gaba synthesis release reuptake and degradation", "Galactose catabolism", "Gamma carboxylation hypusine formation and arylsulfatase activation", "Gamma carboxylation transport and amino terminal cleavage of proteins", "Gap filling dna repair synthesis and ligation in gg ner", "Gap junction assembly", "Gap junction degradation", "Gap junction trafficking and regulation", "Gastrin creb signalling pathway via pkc and mapk", "Gene and protein expression by jak stat signaling after interleukin 12 stimulation", "Gene silencing by rna", "Generation of second messenger molecules", "Global genome nucleotide excision repair gg ner", "Glucagon like peptide 1 glp1 regulates insulin secretion", "Glucagon signaling in metabolic regulation", "Gluconeogenesis", "Glucose metabolism", "Glucuronidation", "Glutamate and glutamine metabolism", "Glutamate neurotransmitter release cycle", "Glutathione conjugation", "Glutathione synthesis and recycling", "Glycerophospholipid biosynthesis", "Glycerophospholipid catabolism", "Glycogen breakdown glycogenolysis", "Glycogen metabolism", "Glycogen storage diseases", "Glycogen synthesis", "Glycolysis", "Glycosaminoglycan metabolism", "Glycosphingolipid metabolism", "Glyoxylate metabolism and glycine degradation", "Golgi associated vesicle biogenesis", "Golgi cisternae pericentriolar stack reorganization", "Golgi to er retrograde transport", "Gp1b ix v activation signalling", "Gpcr ligand binding", "Gpvi mediated activation cascade", "Grb2 events in erbb2 signaling", "Grb2 sos provides linkage to mapk signaling for integrins", "Growth hormone receptor signaling", "Hats acetylate histones", "Hcmv early events", "Hcmv infection", "Hcmv late events", "Hdacs deacetylate histones", "Hdl clearance", "Hdms demethylate histones", "Hdr through homologous recombination hrr", "Hdr through mmej alt nhej", "Hdr through single strand annealing ssa", "Hedgehog ligand biogenesis", "Hedgehog off state", "Hedgehog on state", "Heme biosynthesis", "Heme degradation", "Heme signaling", "Hemostasis", "Heparan sulfate heparin hs gag metabolism", "Hiv elongation arrest and recovery", "Hiv infection", "Hiv life cycle", "Hiv transcription elongation", "Hiv transcription initiation", "Homologous dna pairing and strand exchange", "Homology directed repair", "Host interactions of hiv factors", "Hs gag degradation", "Hsf1 activation", "Hsf1 dependent transactivation", "Hsp90 chaperone cycle for steroid hormone receptors shr in the presence of ligand", "Hur elavl1 binds and stabilizes mrna", "Hyaluronan metabolism", "Hyaluronan uptake and degradation", "Hydrolysis of lpc", "Ikba variant leads to eda id", "Ikk complex recruitment mediated by rip1", "Immunoregulatory interactions between a lymphoid and a non lymphoid cell", "Inactivation of cdc42 and rac1", "Inactivation of csf3 g csf signaling", "Incretin synthesis secretion and inactivation", "Infection with mycobacterium tuberculosis", "Infectious disease", "Inflammasomes", "Influenza infection", "Inhibition of dna recombination at telomere", "Inhibition of replication initiation of damaged dna by rb1 e2f1", "Inhibition of the proteolytic activity of apc c required for the onset of anaphase by mitotic spindle checkpoint components", "Initiation of nuclear envelope ne reformation", "Inla mediated entry of listeria monocytogenes into host cells", "Inlb mediated entry of listeria monocytogenes into host cell", "Innate immune system", "Inositol phosphate metabolism", "Insertion of tail anchored proteins into the endoplasmic reticulum membrane", "Insulin processing", "Insulin receptor recycling", "Insulin receptor signalling cascade", "Integration of energy metabolism", "Integration of provirus", "Integrin cell surface interactions", "Integrin signaling", "Interaction between l1 and ankyrins", "Interactions of rev with host cellular proteins", "Interactions of vpr with host cellular proteins", "Interconversion of nucleotide di and triphosphates", "Interferon alpha beta signaling", "Interferon gamma signaling", "Interferon signaling", "Interleukin 1 family signaling", "Interleukin 1 processing", "Interleukin 1 signaling", "Interleukin 10 signaling", "Interleukin 12 family signaling", "Interleukin 12 signaling", "Interleukin 15 signaling", "Interleukin 17 signaling", "Interleukin 2 family signaling", "Interleukin 20 family signaling", "Interleukin 21 signaling", "Interleukin 23 signaling", "Interleukin 27 signaling", "Interleukin 3 interleukin 5 and gm csf signaling", "Interleukin 35 signalling", "Interleukin 37 signaling", "Interleukin 4 and interleukin 13 signaling", "Interleukin 6 family signaling", "Interleukin 6 signaling", "Interleukin 7 signaling", "Interleukin 9 signaling", "Interleukin receptor shc signaling", "Intra golgi and retrograde golgi to er traffic", "Intra golgi traffic", "Intracellular signaling by second messengers", "Intraflagellar transport", "Intrinsic pathway for apoptosis", "Intrinsic pathway of fibrin clot formation", "Ion channel transport", "Ion homeostasis", "Ion transport by p type atpases", "Ionotropic activity of kainate receptors", "Irak1 recruits ikk complex", "Irak4 deficiency tlr2 4", "Ire1alpha activates chaperones", "Irf3 mediated activation of type 1 ifn", "Irf3 mediated induction of type i ifn", "Iron uptake and transport", "Irs mediated signalling", "Jnk c jun kinases phosphorylation and activation mediated by activated human tak1", "Josephin domain dubs", "Keratan sulfate biosynthesis", "Keratan sulfate degradation", "Keratan sulfate keratin metabolism", "Keratinization", "Ketone body metabolism", "Killing mechanisms", "Kinesins", "Ksrp khsrp binds and destabilizes mrna", "L1cam interactions", "Lagging strand synthesis", "Laminin interactions", "Late endosomal microautophagy", "Ldl clearance", "Ldl remodeling", "Leishmania infection", "Lgi adam interactions", "Linoleic acid la metabolism", "Lipophagy", "Listeria monocytogenes entry into host cells", "Long term potentiation", "Loss of function of mecp2 in rett syndrome", "Loss of mecp2 binding ability to the ncor smrt complex", "Lrr flii interacting protein 1 lrrfip1 activates type i ifn production", "Lysine catabolism", "Lysosome vesicle biogenesis", "M phase", "Map2k and mapk activation", "Map3k8 tpl2 dependent mapk1 3 activation", "Mapk family signaling cascades", "Mapk targets nuclear events mediated by map kinases", "Mapk1 erk2 activation", "Mapk3 erk1 activation", "Mapk6 mapk4 signaling", "Mastl facilitates mitotic progression", "Maturation of protein 3a", "Maturation of sars cov 1 nucleoprotein", "Maturation of sars cov 1 spike protein", "Maturation of sars cov 2 nucleoprotein", "Maturation of sars cov 2 spike protein", "Mecp2 regulates neuronal receptors and channels", "Mecp2 regulates transcription factors", "Mecp2 regulates transcription of neuronal ligands", "Meiosis", "Meiotic recombination", "Meiotic synapsis", "Membrane trafficking", "Met activates pi3k akt signaling", "Met activates ptk2 signaling", "Met activates ptpn11", "Met activates rap1 and rac1", "Met activates ras signaling", "Met interacts with tns proteins", "Met promotes cell motility", "Met receptor recycling", "Metabolic disorders of biological oxidation enzymes", "Metabolism of amino acids and derivatives", "Metabolism of angiotensinogen to angiotensins", "Metabolism of carbohydrates", "Metabolism of cofactors", "Metabolism of fat soluble vitamins", "Metabolism of folate and pterines", "Metabolism of ingested semet sec mesec into h2se", "Metabolism of lipids", "Metabolism of nitric oxide nos3 activation and regulation", "Metabolism of nucleotides", "Metabolism of polyamines", "Metabolism of porphyrins", "Metabolism of rna", "Metabolism of steroid hormones", "Metabolism of steroids", "Metabolism of vitamins and cofactors", "Metabolism of water soluble vitamins and cofactors", "Metal ion slc transporters", "Metalloprotease dubs", "Methionine salvage pathway", "Methylation", "Mhc class ii antigen presentation", "Microrna mirna biogenesis", "Miro gtpase cycle", "Miscellaneous transport and binding events", "Mismatch repair", "Mitochondrial biogenesis", "Mitochondrial calcium ion transport", "Mitochondrial fatty acid beta oxidation", "Mitochondrial fatty acid beta oxidation of saturated fatty acids", "Mitochondrial fatty acid beta oxidation of unsaturated fatty acids", "Mitochondrial iron sulfur cluster biogenesis", "Mitochondrial protein import", "Mitochondrial translation", "Mitochondrial trna aminoacylation", "Mitophagy", "Mitotic g1 phase and g1 s transition", "Mitotic g2 g2 m phases", "Mitotic metaphase and anaphase", "Mitotic prometaphase", "Mitotic prophase", "Mitotic spindle checkpoint", "Mitotic telophase cytokinesis", "Molecules associated with elastic fibres", "Mrna capping", "Mrna decay by 3 to 5 exoribonuclease", "Mrna decay by 5 to 3 exoribonuclease", "Mrna editing", "Mrna splicing", "Mrna splicing minor pathway", "Mtor signalling", "Mtorc1 mediated signalling", "Mucopolysaccharidoses", "Muscle contraction", "Myd88 independent tlr4 cascade", "Myogenesis", "N glycan antennae elongation in the medial trans golgi", "N glycan trimming in the er and calnexin calreticulin cycle", "Nade modulates death signalling", "Ncam signaling for neurite out growth", "Neddylation", "Nef and signal transduction", "Nef mediated cd4 down regulation", "Nef mediated cd8 down regulation", "Nef mediated downregulation of mhc class i complex cell surface expression", "Nef mediates down modulation of cell surface receptors by recruiting them to clathrin adapters", "Negative epigenetic regulation of rrna expression", "Negative feedback regulation of mapk pathway", "Negative regulation of fgfr1 signaling", "Negative regulation of fgfr2 signaling", "Negative regulation of fgfr3 signaling", "Negative regulation of fgfr4 signaling", "Negative regulation of flt3", "Negative regulation of mapk pathway", "Negative regulation of met activity", "Negative regulation of nmda receptor mediated neuronal transmission", "Negative regulation of notch4 signaling", "Negative regulation of the pi3k akt network", "Negative regulators of ddx58 ifih1 signaling", "Nephrin family interactions", "Nervous system development", "Netrin 1 signaling", "Netrin mediated repulsion signals", "Neurexins and neuroligins", "Neurofascin interactions", "Neuronal system", "Neurotransmitter clearance", "Neurotransmitter receptors and postsynaptic signal transmission", "Neurotransmitter release cycle", "Neutrophil degranulation", "Nf kb activation through fadd rip 1 pathway mediated by caspase 8 and 10", "Nf kb is activated and signals survival", "Ngf stimulated transcription", "Nicotinamide salvaging", "Nicotinate metabolism", "Nod1 2 signaling pathway", "Non integrin membrane ecm interactions", "Noncanonical activation of notch3", "Nonhomologous end joining nhej", "Nonsense mediated decay nmd", "Norepinephrine neurotransmitter release cycle", "Nostrin mediated enos trafficking", "Notch hlh transcription pathway", "Notch1 intracellular domain regulates transcription", "Notch2 activation and transmission of signal to the nucleus", "Notch3 activation and transmission of signal to the nucleus", "Notch3 intracellular domain regulates transcription", "Notch4 activation and transmission of signal to the nucleus", "Notch4 intracellular domain regulates transcription", "Nr1h2 and nr1h3 mediated signaling", "Nr1h2 nr1h3 regulate gene expression linked to lipogenesis", "Nr1h3 nr1h2 regulate gene expression linked to cholesterol transport and efflux", "Nrage signals death through jnk", "Nrcam interactions", "Nrif signals cell death from the nucleus", "Ns1 mediated effects on host pathways", "Ntrk2 activates rac1", "Nuclear envelope breakdown", "Nuclear envelope ne reassembly", "Nuclear events kinase and transcription factor activation", "Nuclear events stimulated by alk signaling in cancer", "Nuclear import of rev protein", "Nuclear pore complex npc disassembly", "Nuclear receptor transcription pathway", "Nuclear signaling by erbb4", "Nucleotide binding domain leucine rich repeat containing receptor nlr signaling pathways", "Nucleotide biosynthesis", "Nucleotide catabolism", "Nucleotide excision repair", "Nucleotide salvage", "O linked glycosylation", "O linked glycosylation of mucins", "Oas antiviral response", "Oncogene induced senescence", "Oncogenic mapk signaling", "Opioid signalling", "Orc1 removal from chromatin", "Organelle biogenesis and maintenance", "Organic anion transporters", "Other interleukin signaling", "Other semaphorin interactions", "Ovarian tumor domain proteases", "Oxidative stress induced senescence", "P130cas linkage to mapk signaling for integrins", "P38mapk events", "P75 ntr receptor mediated signalling", "P75ntr negatively regulates cell cycle via sc1", "P75ntr recruits signalling complexes", "P75ntr regulates axonogenesis", "P75ntr signals via nf kb", "Parasite infection", "Passive transport by aquaporins", "Pcna dependent long patch base excision repair", "Pcp ce pathway", "Pd 1 signaling", "Pecam1 interactions", "Pentose phosphate pathway", "Peptide hormone metabolism", "Peptide ligand binding receptors", "Perk regulates gene expression", "Peroxisomal lipid metabolism", "Peroxisomal protein import", "Pexophagy", "Phase 0 rapid depolarisation", "Phase i functionalization of compounds", "Phase ii conjugation of compounds", "Phenylalanine and tyrosine metabolism", "Phenylalanine metabolism", "Phosphate bond hydrolysis by nudt proteins", "Phospholipase c mediated cascade fgfr2", "Phospholipase c mediated cascade fgfr4", "Phospholipid metabolism", "Phosphorylation of emi1", "Phosphorylation of the apc c", "Pi 3k cascade fgfr1", "Pi 3k cascade fgfr2", "Pi 3k cascade fgfr3", "Pi 3k cascade fgfr4", "Pi metabolism", "Pi3k akt signaling in cancer", "Pi3k events in erbb2 signaling", "Pi5p regulates tp53 acetylation", "Pink1 prkn mediated mitophagy", "Piwi interacting rna pirna biogenesis", "Pka activation in glucagon signalling", "Pka mediated phosphorylation of creb", "Pkmts methylate histone lysines", "Plasma lipoprotein assembly", "Plasma lipoprotein assembly remodeling and clearance", "Plasma lipoprotein clearance", "Plasma lipoprotein remodeling", "Platelet activation signaling and aggregation", "Platelet adhesion to exposed collagen", "Platelet aggregation plug formation", "Platelet calcium homeostasis", "Platelet homeostasis", "Platelet sensitization by ldl", "Polb dependent long patch base excision repair", "Polo like kinase mediated events", "Polymerase switching", "Polymerase switching on the c strand of the telomere", "Positive epigenetic regulation of rrna expression", "Post chaperonin tubulin folding pathway", "Post translational modification synthesis of gpi anchored proteins", "Post translational protein modification", "Postmitotic nuclear pore complex npc reformation", "Potential therapeutics for sars", "Pou5f1 oct4 sox2 nanog activate genes related to proliferation", "Pou5f1 oct4 sox2 nanog repress genes related to differentiation", "Pp2a mediated dephosphorylation of key metabolic factors", "Prc2 methylates histones and dna", "Pre notch expression and processing", "Pre notch processing in golgi", "Pregnenolone biosynthesis", "Prevention of phagosomal lysosomal fusion", "Processing and activation of sumo", "Processing of capped intron containing pre mrna", "Processing of capped intronless pre mrna", "Processing of dna double strand break ends", "Processing of intronless pre mrnas", "Processing of smdt1", "Processive synthesis on the c strand of the telomere", "Processive synthesis on the lagging strand", "Programmed cell death", "Prolactin receptor signaling", "Prolonged erk activation events", "Propionyl coa catabolism", "Protein folding", "Protein localization", "Protein methylation", "Protein protein interactions at synapses", "Protein repair", "Protein ubiquitination", "Proton coupled monocarboxylate transport", "Pten regulation", "Ptk6 expression", "Ptk6 regulates cell cycle", "Ptk6 regulates proteins involved in rna processing", "Ptk6 regulates rho gtpases ras gtpase and map kinases", "Ptk6 regulates rtks and their effectors akt1 and dok1", "Purine catabolism", "Purine ribonucleoside monophosphate biosynthesis", "Purine salvage", "Purinergic signaling in leishmaniasis infection", "Pyrimidine salvage", "Pyroptosis", "Pyruvate metabolism", "Pyruvate metabolism and citric acid tca cycle", "Ra biosynthesis pathway", "Rab gefs exchange gtp for gdp on rabs", "Rab geranylgeranylation", "Rab regulation of trafficking", "Rac1 gtpase cycle", "Rac2 gtpase cycle", "Rac3 gtpase cycle", "Raf activation", "Raf independent mapk1 3 activation", "Rap1 signalling", "Ras activation upon ca2 influx through nmda receptor", "Ras processing", "Reactions specific to the complex n glycan synthesis pathway", "Receptor mediated mitophagy", "Receptor type tyrosine protein phosphatases", "Recognition and association of dna glycosylase with site containing an affected purine", "Recognition of dna damage by pcna containing replication complex", "Recruitment of mitotic centrosome proteins and complexes", "Recruitment of numa to mitotic centrosomes", "Recycling of eif2 gdp", "Recycling pathway of l1", "Reduction of cytosolic ca levels", "Regulated necrosis", "Regulated proteolysis of p75ntr", "Regulation by c flip", "Regulation of bach1 activity", "Regulation of beta cell development", "Regulation of cholesterol biosynthesis by srebp srebf", "Regulation of commissural axon pathfinding by slit and robo", "Regulation of cytoskeletal remodeling and cell spreading by ipp complex components", "Regulation of expression of slits and robos", "Regulation of fzd by ubiquitination", "Regulation of gene expression in beta cells", "Regulation of gene expression in late stage branching morphogenesis pancreatic bud precursor cells", "Regulation of glucokinase by glucokinase regulatory protein", "Regulation of glycolysis by fructose 2 6 bisphosphate metabolism", "Regulation of hmox1 expression and activity", "Regulation of hsf1 mediated heat shock response", "Regulation of ifna signaling", "Regulation of ifng signaling", "Regulation of innate immune responses to cytosolic dna", "Regulation of insulin like growth factor igf transport and uptake by insulin like growth factor binding proteins igfbps", "Regulation of insulin secretion", "Regulation of kit signaling", "Regulation of lipid metabolism by pparalpha", "Regulation of localization of foxo transcription factors", "Regulation of mecp2 expression and activity", "Regulation of mrna stability by proteins that bind au rich elements", "Regulation of plk1 activity at g2 m transition", "Regulation of pten gene transcription", "Regulation of pten localization", "Regulation of pten mrna translation", "Regulation of pten stability and activity", "Regulation of pyruvate dehydrogenase pdh complex", "Regulation of ras by gaps", "Regulation of runx1 expression and activity", "Regulation of runx2 expression and activity", "Regulation of runx3 expression and activity", "Regulation of signaling by cbl", "Regulation of tlr by endogenous ligand", "Regulation of tnfr1 signaling", "Regulation of tp53 activity", "Regulation of tp53 activity through acetylation", "Regulation of tp53 activity through association with co factors", "Regulation of tp53 activity through methylation", "Regulation of tp53 activity through phosphorylation", "Regulation of tp53 expression and degradation", "Release of apoptotic factors from the mitochondria", "Repression of wnt target genes", "Reproduction", "Resolution of abasic sites ap sites", "Resolution of ap sites via the multiple nucleotide patch replacement pathway", "Resolution of d loop structures", "Resolution of d loop structures through synthesis dependent strand annealing sdsa", "Resolution of sister chromatid cohesion", "Respiratory electron transport", "Respiratory electron transport atp synthesis by chemiosmotic coupling and heat production by uncoupling proteins", "Response of eif2ak1 hri to heme deficiency", "Response of eif2ak4 gcn2 to amino acid deficiency", "Response of mtb to phagocytosis", "Response to elevated platelet cytosolic ca2", "Ret signaling", "Retrograde neurotrophin signalling", "Retrograde transport at the trans golgi network", "Rho gtpase cycle", "Rho gtpase effectors", "Rho gtpases activate cit", "Rho gtpases activate formins", "Rho gtpases activate iqgaps", "Rho gtpases activate ktn1", "Rho gtpases activate nadph oxidases", "Rho gtpases activate paks", "Rho gtpases activate pkns", "Rho gtpases activate rocks", "Rho gtpases activate wasps and waves", "Rhoa gtpase cycle", "Rhob gtpase cycle", "Rhobtb gtpase cycle", "Rhobtb1 gtpase cycle", "Rhobtb2 gtpase cycle", "Rhobtb3 atpase cycle", "Rhoc gtpase cycle", "Rhod gtpase cycle", "Rhof gtpase cycle", "Rhog gtpase cycle", "Rhoh gtpase cycle", "Rhoj gtpase cycle", "Rhoq gtpase cycle", "Rhot1 gtpase cycle", "Rhou gtpase cycle", "Rhov gtpase cycle", "Rip mediated nfkb activation via zbp1", "Ripk1 mediated regulated necrosis", "Rmts methylate histone arginines", "Rna polymerase i promoter escape", "Rna polymerase i transcription", "Rna polymerase i transcription initiation", "Rna polymerase i transcription termination", "Rna polymerase ii transcribes snrna genes", "Rna polymerase ii transcription", "Rna polymerase ii transcription termination", "Rna polymerase iii chain elongation", "Rna polymerase iii transcription", "Rna polymerase iii transcription initiation from type 1 promoter", "Rna polymerase iii transcription initiation from type 3 promoter", "Rna polymerase iii transcription termination", "Rnd1 gtpase cycle", "Rnd2 gtpase cycle", "Rnd3 gtpase cycle", "Robo receptors bind akap5", "Role of abl in robo slit signaling", "Role of lat2 ntal lab on calcium mobilization", "Role of phospholipids in phagocytosis", "Role of second messengers in netrin 1 signaling", "Rora activates gene expression", "Ros and rns production in phagocytes", "Rrna modification in the nucleus and cytosol", "Rrna processing", "Rrna processing in the mitochondrion", "Rsk activation", "Runx1 interacts with co factors whose precise effect on runx1 targets is not known", "Runx1 regulates estrogen receptor mediated transcription", "Runx1 regulates expression of components of tight junctions", "Runx1 regulates genes involved in megakaryocyte differentiation and platelet function", "Runx1 regulates transcription of genes involved in differentiation of hscs", "Runx1 regulates transcription of genes involved in differentiation of myeloid cells", "Runx2 regulates bone development", "Runx2 regulates genes involved in cell migration", "Runx2 regulates osteoblast differentiation", "Runx3 regulates cdkn1a transcription", "Runx3 regulates notch signaling", "Runx3 regulates p14 arf", "Runx3 regulates wnt signaling", "S phase", "Sars cov 1 infection", "Sars cov 2 infection", "Sars cov infections", "Scavenging by class a receptors", "Scavenging by class b receptors", "Scavenging by class f receptors", "Scf skp2 mediated degradation of p27 p21", "Sealing of the nuclear envelope ne by escrt iii", "Selective autophagy", "Selenoamino acid metabolism", "Sema3a pak dependent axon repulsion", "Sema3a plexin repulsion signaling by inhibiting integrin adhesion", "Sema4d in semaphorin signaling", "Sema4d induced cell migration and growth cone collapse", "Sema4d mediated inhibition of cell attachment and migration", "Semaphorin interactions", "Senescence associated secretory phenotype sasp", "Sensing of dna double strand breaks", "Sensory perception", "Sensory processing of sound", "Sensory processing of sound by outer hair cells of the cochlea", "Separation of sister chromatids", "Serine biosynthesis", "Serotonin neurotransmitter release cycle", "Shc mediated cascade fgfr1", "Shc mediated cascade fgfr3", "Shc mediated cascade fgfr4", "Shc related events triggered by igf1r", "Shc1 events in egfr signaling", "Shc1 events in erbb2 signaling", "Shc1 events in erbb4 signaling", "Sialic acid metabolism", "Signal amplification", "Signal attenuation", "Signal regulatory protein family interactions", "Signal transduction by l1", "Signaling by activin", "Signaling by alk", "Signaling by alk in cancer", "Signaling by bmp", "Signaling by braf and raf1 fusions", "Signaling by csf3 g csf", "Signaling by ctnnb1 phospho site mutants", "Signaling by cytosolic fgfr1 fusion mutants", "Signaling by egfr", "Signaling by egfr in cancer", "Signaling by erbb2", "Signaling by erbb2 ecd mutants", "Signaling by erbb2 in cancer", "Signaling by erbb4", "Signaling by erythropoietin", "Signaling by fgfr", "Signaling by fgfr in disease", "Signaling by fgfr1", "Signaling by fgfr1 in disease", "Signaling by fgfr2", "Signaling by fgfr2 iiia tm", "Signaling by fgfr2 in disease", "Signaling by fgfr3", "Signaling by fgfr3 fusions in cancer", "Signaling by fgfr4", "Signaling by fgfr4 in disease", "Signaling by flt3 fusion proteins", "Signaling by flt3 itd and tkd mutants", "Signaling by gpcr", "Signaling by hedgehog", "Signaling by hippo", "Signaling by insulin receptor", "Signaling by interleukins", "Signaling by kit in disease", "Signaling by leptin", "Signaling by mapk mutants", "Signaling by met", "Signaling by moderate kinase activity braf mutants", "Signaling by mras complex mutants", "Signaling by nodal", "Signaling by notch", "Signaling by notch1", "Signaling by notch1 pest domain mutants in cancer", "Signaling by notch2", "Signaling by notch3", "Signaling by notch4", "Signaling by ntrk2 trkb", "Signaling by ntrk3 trkc", "Signaling by ntrks", "Signaling by nuclear receptors", "Signaling by pdgf", "Signaling by pdgfr in disease", "Signaling by pdgfra transmembrane juxtamembrane and kinase domain mutants", "Signaling by ptk6", "Signaling by receptor tyrosine kinases", "Signaling by retinoic acid", "Signaling by rho gtpases miro gtpases and rhobtb3", "Signaling by robo receptors", "Signaling by scf kit", "Signaling by tgf beta receptor complex", "Signaling by tgf beta receptor complex in cancer", "Signaling by tgfb family members", "Signaling by the b cell receptor bcr", "Signaling by type 1 insulin like growth factor 1 receptor igf1r", "Signaling by vegf", "Signaling by wnt", "Signaling by wnt in cancer", "Signalling to erks", "Signalling to ras", "Sirt1 negatively regulates rrna expression", "Slbp dependent processing of replication dependent histone pre mrnas", "Slc mediated transmembrane transport", "Slc transporter disorders", "Smac xiap regulated apoptotic response", "Smad2 smad3 smad4 heterotrimer regulates transcription", "Small interfering rna sirna biogenesis", "Smooth muscle contraction", "Snrnp assembly", "Sodium calcium exchangers", "Sos mediated signalling", "Sphingolipid de novo biosynthesis", "Sphingolipid metabolism", "Spry regulation of fgf signaling", "Srp dependent cotranslational protein targeting to membrane", "Stabilization of p53", "Stat3 nuclear events downstream of alk signaling", "Stat5 activation", "Stat5 activation downstream of flt3 itd mutants", "Stimuli sensing channels", "Sting mediated induction of host immune responses", "Striated muscle contraction", "Sulfide oxidation to sulfate", "Sulfur amino acid metabolism", "Sumo is conjugated to e1 uba2 sae1", "Sumo is transferred from e1 to e2 ube2i ubc9", "Sumoylation", "Sumoylation of chromatin organization proteins", "Sumoylation of dna damage response and repair proteins", "Sumoylation of dna methylation proteins", "Sumoylation of dna replication proteins", "Sumoylation of immune response proteins", "Sumoylation of rna binding proteins", "Sumoylation of sumoylation proteins", "Sumoylation of transcription cofactors", "Sumoylation of transcription factors", "Sumoylation of ubiquitinylation proteins", "Suppression of apoptosis", "Suppression of phagosomal maturation", "Surfactant metabolism", "Switching of origins to a post replicative state", "Synaptic adhesion like molecules", "Syndecan interactions", "Synthesis of 5 eicosatetraenoic acids", "Synthesis of active ubiquitin roles of e1 and e2 enzymes", "Synthesis of bile acids and bile salts", "Synthesis of bile acids and bile salts via 24 hydroxycholesterol", "Synthesis of bile acids and bile salts via 7alpha hydroxycholesterol", "Synthesis of diphthamide eef2", "Synthesis of dna", "Synthesis of epoxy eet and dihydroxyeicosatrienoic acids dhet", "Synthesis of gdp mannose", "Synthesis of ip2 ip and ins in the cytosol", "Synthesis of ip3 and ip4 in the cytosol", "Synthesis of ketone bodies", "Synthesis of leukotrienes lt and eoxins ex", "Synthesis of lipoxins lx", "Synthesis of pa", "Synthesis of pc", "Synthesis of pe", "Synthesis of pg", "Synthesis of pips at the early endosome membrane", "Synthesis of pips at the er membrane", "Synthesis of pips at the golgi membrane", "Synthesis of pips at the late endosome membrane", "Synthesis of pips at the plasma membrane", "Synthesis of prostaglandins pg and thromboxanes tx", "Synthesis of substrates in n glycan biosythesis", "Synthesis of udp n acetyl glucosamine", "Synthesis of very long chain fatty acyl coas", "Synthesis secretion and deacylation of ghrelin", "Synthesis secretion and inactivation of glucagon like peptide 1 glp 1", "Synthesis secretion and inactivation of glucose dependent insulinotropic polypeptide gip", "Tak1 activates nfkb by phosphorylation and activation of ikks complex", "Tbc rabgaps", "Tcf dependent signaling in response to wnt", "Tcr signaling", "Telomere c strand lagging strand synthesis", "Telomere c strand synthesis initiation", "Telomere extension by telomerase", "Telomere maintenance", "Termination of translesion dna synthesis", "Tetrahydrobiopterin bh4 synthesis recycling salvage and regulation", "Tfap2a acts as a transcriptional repressor during retinoic acid induced cell differentiation", "Tgf beta receptor signaling activates smads", "Tgf beta receptor signaling in emt epithelial to mesenchymal transition", "The activation of arylsulfatases", "The canonical retinoid cycle in rods twilight vision", "The citric acid tca cycle and respiratory electron transport", "The nlrp3 inflammasome", "The phototransduction cascade", "The role of gtse1 in g2 m progression after g2 checkpoint", "The role of nef in hiv 1 replication and disease pathogenesis", "Thrombin signalling through proteinase activated receptors pars", "Thromboxane signalling through tp receptor", "Ticam1 rip1 mediated ikk complex recruitment", "Tie2 signaling", "Tnf receptor superfamily tnfsf members mediating non canonical nf kb pathway", "Tnf signaling", "Tnfr1 induced nfkappab signaling pathway", "Tnfr1 induced proapoptotic signaling", "Tnfr1 mediated ceramide production", "Tnfr2 non canonical nf kb pathway", "Toll like receptor 9 tlr9 cascade", "Toll like receptor cascades", "Toll like receptor tlr1 tlr2 cascade", "Tp53 regulates metabolic genes", "Tp53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "Tp53 regulates transcription of caspase activators and caspases", "Tp53 regulates transcription of cell cycle genes", "Tp53 regulates transcription of cell death genes", "Tp53 regulates transcription of death receptors and ligands", "Tp53 regulates transcription of dna repair genes", "Tp53 regulates transcription of genes involved in cytochrome c release", "Tp53 regulates transcription of genes involved in g1 cell cycle arrest", "Tp53 regulates transcription of genes involved in g2 cell cycle arrest", "Tp53 regulates transcription of several additional cell death genes whose specific roles in p53 dependent apoptosis remain uncertain", "Traf3 dependent irf activation pathway", "Traf6 mediated irf7 activation", "Traf6 mediated irf7 activation in tlr7 8 or 9 signaling", "Traf6 mediated nf kb activation", "Trafficking and processing of endosomal tlr", "Trafficking of ampa receptors", "Trafficking of glur2 containing ampa receptors", "Trafficking of myristoylated proteins to the cilium", "Trans golgi network vesicle budding", "Transcription coupled nucleotide excision repair tc ner", "Transcription of e2f targets under negative control by dream complex", "Transcription of e2f targets under negative control by p107 rbl1 and p130 rbl2 in complex with hdac1", "Transcription of the hiv genome", "Transcriptional activation of mitochondrial biogenesis", "Transcriptional activity of smad2 smad3 smad4 heterotrimer", "Transcriptional regulation by e2f6", "Transcriptional regulation by mecp2", "Transcriptional regulation by runx1", "Transcriptional regulation by runx2", "Transcriptional regulation by runx3", "Transcriptional regulation by small rnas", "Transcriptional regulation by the ap 2 tfap2 family of transcription factors", "Transcriptional regulation by tp53", "Transcriptional regulation by ventx", "Transcriptional regulation of granulopoiesis", "Transcriptional regulation of pluripotent stem cells", "Transcriptional regulation of white adipocyte differentiation", "Transferrin endocytosis and recycling", "Translation", "Translation of replicase and assembly of the replication transcription complex", "Translation of sars cov 1 structural proteins", "Translation of sars cov 2 structural proteins", "Translesion synthesis by polh", "Translesion synthesis by polk", "Translesion synthesis by y family dna polymerases bypasses lesions on dna template", "Translocation of slc2a4 glut4 to the plasma membrane", "Transmission across chemical synapses", "Transport and synthesis of paps", "Transport of bile salts and organic acids metal ions and amine compounds", "Transport of connexons to the plasma membrane", "Transport of fatty acids", "Transport of inorganic cations anions and amino acids oligopeptides", "Transport of mature mrnas derived from intronless transcripts", "Transport of mature transcript to cytoplasm", "Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane", "Transport of nucleotide sugars", "Transport of small molecules", "Transport of the slbp dependant mature mrna", "Transport of vitamins nucleosides and related molecules", "Transport to the golgi and subsequent modification", "Triglyceride biosynthesis", "Triglyceride catabolism", "Triglyceride metabolism", "Tristetraprolin ttp zfp36 binds and destabilizes mrna", "Trna aminoacylation", "Trna modification in the mitochondrion", "Trna modification in the nucleus and cytosol", "Trna processing", "Trna processing in the mitochondrion", "Trna processing in the nucleus", "Tryptophan catabolism", "Type i hemidesmosome assembly", "Tyrosine catabolism", "Tysnd1 cleaves peroxisomal proteins", "Ub specific processing proteases", "Ubiquinol biosynthesis", "Uch proteinases", "Unblocking of nmda receptors glutamate binding and activation", "Unfolded protein response upr", "Unwinding of dna", "Uptake and actions of bacterial toxins", "Uptake and function of anthrax toxins", "Uptake and function of diphtheria toxin", "Urea cycle", "Vasopressin regulates renal water homeostasis via aquaporins", "Vegfr2 mediated cell proliferation", "Vegfr2 mediated vascular permeability", "Vesicle mediated transport", "Viral messenger rna synthesis", "Visual phototransduction", "Vitamin b1 thiamin metabolism", "Vitamin b2 riboflavin metabolism", "Vitamin b5 pantothenate metabolism", "Vitamin c ascorbate metabolism", "Vitamin d calciferol metabolism", "Vldl assembly", "Vldlr internalisation and degradation", "Vxpx cargo targeting to cilium", "Wax and plasmalogen biosynthesis", "Wnt ligand biogenesis and trafficking", "Wnt mediated activation of dvl", "Wnt5a dependent internalization of fzd2 fzd5 and ror2", "Wnt5a dependent internalization of fzd4", "Zbp1 dai mediated induction of type i ifns", "Zinc efflux and compartmentalization by the slc30 family", "Zinc transporters"], "available_proteins": ["AAAS", "AAMP", "AARS", "AARS2", "AASDHPPT", "AATF", "ABCB1", "ABCB7", "ABCD3", "ABCE1", "ABCF1", "ABHD10", "ABHD12", "ABHD14B", "ABHD6", "ABI1", "ABRAXAS2", "ACAA2", "ACACA", "ACACB", "ACAD9", "ACADM", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACIN1", "ACLY", "ACO2", "ACOT13", "ACOT7", "ACOT9", "ACOX1", "ACOX3", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN2", "ACTN4", "ACTR1A", "ACTR2", "ACTR3", "ADAR", "ADD1", "ADD3", "ADH5", "ADI1", "ADK", "ADPGK", "ADPRHL2", "ADRM1", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGK", "AGL", "AGPAT1", "AGPS", "AHCY", "AHCYL1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AK3", "AKAP1", "AKAP12", "AKAP13", "AKR1A1", "AKR1B1", "AKR7A2", "AKT2", "ALDH18A1", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALG1", "ALG12", "ALKBH5", "AMOT", "ANAPC1", "ANAPC10", "ANAPC5", "ANAPC7", "ANKLE2", "ANLN", "ANO10", "ANP32A", "ANXA1", "ANXA2", "ANXA6", "AP1B1", "AP1G1", "AP1M1", "AP1S2", "AP2A1", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3M1", "APEH", "APEX1", "APLP2", "APOO", "APOOL", "APP", "APRT", "AQR", "ARCN1", "ARF4", "ARFGAP1", "ARFGAP2", "ARFIP2", "ARHGAP17", "ARHGDIA", "ARHGEF2", "ARID1A", "ARIH1", "ARIH2", "ARL1", "ARL2", "ARL3", "ARL6IP5", "ARMCX3", "ARPC1A", "ARPC2", "ARPC3", "ARPC4", "ARSA", "ARV1", "ASAH1", "ASCC2", "ASCC3", "ASH2L", "ASNA1", "ASNS", "ASPH", "ASPSCR1", "ASRGL1", "ATAD1", "ATAD3B", "ATG3", "ATIC", "ATP13A1", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2C1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6", "ATP6AP1", "ATP6AP2", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1D", "ATP6V1E1", "ATP6V1G1", "ATP6V1H", "ATP7B", "AURKA", "B4GAT1", "BAG3", "BAG5", "BAG6", "BAIAP2", "BANF1", "BAZ1B", "BCAP31", "BCS1L", "BICD2", "BIRC6", "BLMH", "BLVRA", "BMS1", "BOLA2*", "BOP1", "BPNT1", "BRAP", "BRD1", "BRD2", "BSG", "BUB1B", "BUB3", "BUD23", "BUD31", "BYSL", "C19orf70", "C1QBP", "C1orf35", "CAB39", "CAD", "CALD1", "CALR", "CALU", "CAMK1", "CAMK2G", "CAND1", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPNS1", "CAPZA1", "CAPZA2", "CAPZB", "CARM1", "CARS", "CASK", "CAST", "CBL", "CBR1", "CBX1", "CBX2", "CBX3", "CBX5", "CCAR1", "CCAR2", "CCDC22", "CCNB1", "CCNB2", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2AP", "CDC20", "CDC23", "CDC25C", "CDC27", "CDC34", "CDC37", "CDC40", "CDC42", "CDC5L", "CDC73", "CDCA8", "CDK1", "CDK2", "CDK4", "CDK5", "CDK6", "CDX2", "CENPF", "CENPP", "CEPT1", "CERS2", "CETN2", "CFL1", "CHAC2", "CHAF1B", "CHAMP1", "CHCHD3", "CHD4", "CHERP", "CHID1", "CHKA", "CHM", "CHMP2A", "CHMP2B", "CHMP7", "CHORDC1", "CHST14", "CHUK", "CIAPIN1", "CKAP4", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLASP2", "CLCN3", "CLCN7", "CLINT1", "CLIP1", "CLNS1A", "CLTC", "CMAS", "CMPK1", "CNDP2", "CNN2", "CNOT1", "CNOT2", "CNOT3", "CNOT4", "CNOT7", "CNOT9", "COL4A3BP", "COLEC12", "COLGALT1", "COMMD2", "COMT", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS7A", "COPS7B", "COPS8", "COPZ1", "COQ3", "COQ9", "CORO1A", "COTL1", "COX2", "COX4I1", "COX5A", "COX6C", "CPD", "CPNE1", "CPNE3", "CPOX", "CPSF1", "CPSF3", "CPSF6", "CPSF7", "CPT2", "CRK", "CRKL", "CRNKL1", "CRTAP", "CS", "CSGALNACT2", "CSK", "CSNK1A1", "CSNK2A1", "CSNK2A2", "CSNK2B", "CSTB", "CSTF1", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTH", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTPS2", "CTSA", "CTSB", "CTSC", "CTTN", "CTU2", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CXADR", "CYB5B", "CYB5R1", "CYB5R3", "CYC1", "CYFIP1", "CYP51A1", "DAP3", "DARS", "DARS2", "DBN1", "DBNL", "DCAF1", "DCAF7", "DCD", "DCPS", "DCTN1", "DCTN2", "DCTN3", "DCTN4", "DCTPP1", "DCUN1D4", "DCXR", "DDB1", "DDOST", "DDRGK1", "DDX1", "DDX17", "DDX20", "DDX21", "DDX23", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX52", "DDX56", "DDX6", "DEK", "DERL1", "DFFA", "DHCR24", "DHCR7", "DHFR", "DHX15", "DHX16", "DHX36", "DHX37", "DHX9", "DIABLO", "DIAPH1", "DIAPH2", "DIAPH3", "DIDO1", "DIEXF", "DIMT1", "DIS3", "DKC1", "DLAT", "DLD", "DLST", "DNA2", "DNAJA1", "DNAJA2", "DNAJB1", "DNAJC11", "DNAJC2", "DNAJC3", "DNAJC7", "DNAJC8", "DNASE2", "DNM1L", "DNM2", "DNMT1", "DNPH1", "DOCK7", "DOHH", "DPH2", "DPH5", "DPM1", "DPY30", "DPYSL2", "DPYSL5", "DR1", "DSC1", "DSC3", "DSG2", "DSP", "DST", "DTYMK", "DUSP3", "DUSP9", "DUT", "DYNC1H1", "DYNC1LI1", "DYNC1LI2", "DYNC2H1", "DYNLL1", "EBNA1BP2", "ECE1", "ECH1", "ECHS1", "ECI1", "ECI2", "ECSIT", "EDC3", "EDC4", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EFTUD2", "EHD1", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A3", "EIF4B", "EIF4E", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "ELAC2", "ELAVL1", "ELMO2", "ELOA", "ELOB", "ELOC", "ELP1", "ELP2", "ELP3", "ELP4", "EMD", "EMG1", "ENAH", "ENDOD1", "ENO1", "ENO2", "ENSA", "EPB41", "EPB41L2", "EPB41L5", "EPHA7", "EPHX1", "EPHX2", "EPRS", "EPS15", "EPS15L1", "ERAL1", "ERAP1", "ERCC2", "ERI1", "ERLIN1", "ERLIN2", "ERO1A", "ESD", "ESYT1", "ETF1", "ETFA", "ETFB", "ETFDH", "EXO1", "EXOC2", "EXOC3", "EXOC5", "EXOC7", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "EZR", "FAF2", "FAH", "FAHD1", "FAM114A2", "FAM49B", "FAM98B", "FANCI", "FAR1", "FARSA", "FARSB", "FASN", "FAU", "FBL", "FBXO22", "FBXO7", "FDFT1", "FDPS", "FECH", "FEN1", "FGFR1OP", "FH", "FIP1L1", "FIS1", "FKBP14", "FKBP1A", "FKBP4", "FKBP5", "FKBP8", "FLAD1", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FN3KRP", "FNTB", "FSCN1", "FTO", "FTSJ3", "FUCA1", "FUCA2", "FUS", "FXR1", "G6PD", "GAA", "GABARAPL2", "GADD45GIP1", "GAK", "GALK1", "GALNT1", "GALNT2", "GALNT7", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GBA", "GBF1", "GCAT", "GCDH", "GCFC2", "GCLC", "GCLM", "GCN1", "GDI1", "GDI2", "GDPD1", "GEMIN4", "GEMIN5", "GET4", "GFM1", "GFPT1", "GGCT", "GGCX", "GGH", "GHDC", "GINS3", "GINS4", "GLA", "GLB1", "GLDC", "GLG1", "GLMN", "GLO1", "GLRX", "GLRX3", "GLRX5", "GLS", "GLUD1", "GM2A", "GMPPB", "GMPS", "GNA13", "GNAI1", "GNAI2", "GNAI3", "GNL3", "GNPAT", "GNPDA1", "GNS", "GOLGA3", "GOLGB1", "GOLIM4", "GOPC", "GORASP2", "GOT1", "GOT2", "GPAM", "GPD2", "GPI", "GPKOW", "GPS1", "GRB2", "GRHPR", "GRPEL1", "GRSF1", "GSK3B", "GSPT1", "GSR", "GSS", "GSTK1", "GSTM3", "GSTO1", "GSTZ1", "GTF3C1", "GTF3C2", "GTF3C3", "GTF3C4", "GTPBP3", "GUSB", "H1F0", "H2AFX", "H4C1*", "HACD3", "HACL1", "HADH", "HADHA", "HADHB", "HAT1", "HAUS3", "HAUS5", "HAUS8", "HBS1L", "HCFC1", "HDAC2", "HDGF", "HDLBP", "HEATR1", "HEBP1", "HEBP2", "HECTD1", "HECTD3", "HEXA", "HEXB", "HIBADH", "HIBCH", "HIF1AN", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HLTF", "HM13", "HMBS", "HMGA1", "HMGB1", "HMGB2", "HMGCS1", "HMOX1", "HMOX2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPK", "HNRNPL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HPRT1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA13", "HSPA14", "HSPA1B", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPB1", "HSPD1", "HSPE1", "HSPH1", "HUWE1", "HYOU1", "IARS", "IARS2", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDI1", "IFT27", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "ILF2", "IMMT", "IMP4", "IMPACT", "IMPDH1", "IMPDH2", "INCENP", "INTS11", "INTS14", "INTS7", "INTS9", "IPO5", "IPO8", "IPO9", "IQGAP1", "IRS4", "ISCU", "IST1", "ISYNA1", "ITGB1", "ITM2C", "ITPA", "IVD", "JUP", "KARS", "KDELR1", "KDM1A", "KDM1B", "KDM3B", "KDSR", "KHDRBS1", "KHSRP", "KIAA0391", "KIF11", "KIF15", "KIF18B", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF4A", "KIF5B", "KIF7", "KIFC1", "KLC1", "KMT2A", "KNTC1", "KPNA1", "KPNA2", "KPNA3", "KPNB1", "KRR1", "KTN1", "LAMP1", "LAMTOR1", "LARS", "LARS2", "LAS1L", "LBR", "LCLAT1", "LDHA", "LDHB", "LEMD2", "LEMD3", "LETM1", "LGALS3", "LGALS3BP", "LGMN", "LIG1", "LIG3", "LIPA", "LLGL1", "LMAN1", "LMAN2", "LMNA", "LMNB1", "LNPEP", "LPCAT1", "LPCAT3", "LPGAT1", "LRPPRC", "LSM2", "LSM6", "LSM7", "LSS", "LTA4H", "LTN1", "LTV1", "LYPLA1", "M6PR", "MAD2L1", "MAGED2", "MAN2A1", "MAN2B1", "MANBA", "MANF", "MAP2K1", "MAPK1", "MAPRE1", "MARC1", "MARCKS", "MARS", "MAT2A", "MAT2B", "MAVS", "MBD3", "MBOAT7", "MCAT", "MCCC1", "MCCC2", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCU", "MDC1", "MDH1", "MDH2", "ME1", "MECP2", "MED1", "MED21", "MED23", "MED24", "MED25", "MED4", "MFN2", "MGST2", "MGST3", "MIA2", "MICU1", "MID1", "MIF", "MINPP1", "MIPEP", "MLEC", "MMGT1", "MMS19", "MOGS", "MORF4L1", "MORF4L2", "MOSPD2", "MOV10", "MPC2", "MPHOSPH10", "MPHOSPH6", "MPI", "MPRIP", "MPST", "MRE11", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL14", "MRPL15", "MRPL19", "MRPL21", "MRPL28", "MRPL3", "MRPL37", "MRPL38", "MRPL39", "MRPL40", "MRPL44", "MRPL45", "MRPL46", "MRPL47", "MRPL48", "MRPL49", "MRPL50", "MRPL53", "MRPL9", "MRPS11", "MRPS2", "MRPS22", "MRPS23", "MRPS25", "MRPS27", "MRPS28", "MRPS30", "MRPS31", "MRPS33", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRPS9", "MSH2", "MSH3", "MSH6", "MSI2", "MSN", "MTA1", "MTA2", "MTAP", "MTCH1", "MTHFD1", "MTHFD1L", "MTHFD2", "MTMR2", "MTMR6", "MTOR", "MTR", "MTX1", "MTX2", "MVK", "MYBBP1A", "MYDGF", "MYH10", "MYH14", "MYH9", "MYL6", "MYO1C", "MYO6", "NAE1", "NAGLU", "NAMPT", "NANS", "NAPA", "NAPG", "NARS", "NAT10", "NAXE", "NBN", "NCAPD2", "NCAPG", "NCAPH", "NCBP1", "NCKAP1", "NCKIPSD", "NCL", "NCSTN", "NDC1", "NDUFA10", "NDUFA3", "NDUFA4", "NDUFA5", "NDUFA7", "NDUFA9", "NDUFAF4", "NDUFAF7", "NDUFB10", "NDUFB3", "NDUFB4", "NDUFB5", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS6", "NDUFS7", "NDUFV1", "NDUFV2", "NECAP1", "NECAP2", "NEFL", "NEK9", "NELFA", "NELFB", "NELFCD", "NELFE", "NHLRC2", "NHP2", "NIPBL", "NLN", "NME1", "NME7", "NMT1", "NNT", "NOB1", "NOC2L", "NOC4L", "NOL11", "NOL6", "NOL9", "NOP14", "NOP2", "NOP56", "NOP58", "NOSIP", "NPC1", "NPC2", "NPEPPS", "NPLOC4", "NPM1", "NRP1", "NSD2", "NSDHL", "NSF", "NSFL1C", "NSUN2", "NT5C2", "NT5C3B", "NTHL1", "NUB1", "NUBP2", "NUCB1", "NUDC", "NUDT1", "NUDT12", "NUDT21", "NUDT5", "NUF2", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP160", "NUP188", "NUP205", "NUP210", "NUP214", "NUP37", "NUP43", "NUP50", "NUP54", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NUPL2", "NXF1", "OAT", "OCLN", "OCRL", "OGDH", "OGT", "OLA1", "OPA1", "OSBP", "OSBPL8", "OSBPL9", "OSGEP", "OTUB1", "OTULIN", "OXA1L", "P3H1", "P4HA1", "P4HB", "PA2G4", "PABPC1", "PABPN1", "PACSIN2", "PAF1", "PAFAH1B1", "PAFAH1B2", "PAFAH1B3", "PAICS", "PAK1", "PAK2", "PANK4", "PAPOLA", "PAPSS1", "PARK7", "PARN", "PARP1", "PATL1", "PBRM1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCK2", "PCLAF", "PCM1", "PCMT1", "PCNA", "PDAP1", "PDCD11", "PDCD4", "PDCD6", "PDCD6IP", "PDE12", "PDE6D", "PDHA1", "PDHB", "PDIA3", "PDIA6", "PDK1", "PDK3", "PDLIM5", "PDLIM7", "PDPR", "PDS5A", "PDS5B", "PDXK", "PEBP1", "PECR", "PELP1", "PES1", "PEX14", "PEX19", "PFAS", "PFDN2", "PFDN4", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGM3", "PGP", "PGRMC1", "PGRMC2", "PHB", "PHB2", "PHF5A", "PHF8", "PHGDH", "PHIP", "PHKA1", "PICALM", "PIGT", "PIK3C2A", "PIK3R4", "PIN1", "PIP4K2C", "PIR", "PISD", "PITPNB", "PITRM1", "PKM", "PKMYT1", "PKN2", "PLA2G15", "PLCG1", "PLD3", "PLD6", "PLEC", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLRG1", "PMPCA", "PMPCB", "PNO1", "PNP", "POLA1", "POLA2", "POLD1", "POLD2", "POLD3", "POLDIP2", "POLDIP3", "POLE", "POLE3", "POLE4", "POLR1A", "POLR1B", "POLR1E", "POLR2A", "POLR2B", "POLR2C", "POLR2G", "POLR3A", "POLR3C", "POLRMT", "PON2", "POP1", "POR", "PPA1", "PPA2", "PPAT", "PPFIA1", "PPIB", "PPID", "PPIH", "PPIL4", "PPME1", "PPP1CA", "PPP1CB", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP4C", "PPP5C", "PPP6C", "PPT1", "PPT2", "PQBP1", "PRCC", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PRIM1", "PRIM2", "PRKAG1", "PRKAR1A", "PRKAR2A", "PRKCD", "PRKCSH", "PRKDC", "PRKRA", "PRMT1", "PRMT3", "PRMT5", "PRPF19", "PRPF3", "PRPF31", "PRPF4", "PRPF40A", "PRPF6", "PRPF8", "PRPS1", "PSAP", "PSAT1", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD6", "PSMD7", "PSMD8", "PSME1", "PSME2", "PSME3", "PSME4", "PSMF1", "PTBP1", "PTCD3", "PTDSS1", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTPN1", "PTPN11", "PTRH2", "PUF60", "PUS1", "PUS7", "PWP2", "PXMP2", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QDPR", "QKI", "RAB10", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB21", "RAB23", "RAB24", "RAB2A", "RAB35", "RAB3GAP2", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RAB8A", "RABEPK", "RABGAP1", "RABGGTA", "RAC1", "RACGAP1", "RACK1", "RAD21", "RAD23A", "RAD23B", "RAD50", "RAE1", "RALA", "RAN", "RANBP1", "RANBP2", "RANBP9", "RANGAP1", "RANGRF", "RAP2B", "RAPGEF2", "RARS", "RARS2", "RB1", "RBBP4", "RBBP6", "RBBP7", "RBM14", "RBM17", "RBM22", "RBM28", "RBM4", "RBM5", "RBM8A", "RBMX", "RCC1", "RCC2", "RCL1", "RCN1", "RCOR1", "RDH11", "RDH13", "RDX", "RELA", "REPS1", "RETSAT", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RHEB", "RHOT1", "RHOT2", "RIDA", "RIF1", "RINT1", "RIOK2", "RNASET2", "RNF2", "RNF40", "ROCK1", "ROCK2", "RPA1", "RPA2", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPN1", "RPN2", "RPP30", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RRBP1", "RRM1", "RRM2", "RRP1", "RRP8", "RSF1", "RSU1", "RTCB", "RTN3", "RTN4", "RTRAF", "RUFY1", "RUVBL1", "RUVBL2", "S100A10", "S100A11", "SACM1L", "SAE1", "SAFB", "SAMHD1", "SAMM50", "SAP130", "SAP18", "SAP30BP", "SARNP", "SARS", "SARS2", "SART1", "SC5D", "SCARB1", "SCARB2", "SCCPDH", "SCD", "SCFD1", "SCO1", "SCO2", "SCP2", "SCRIB", "SDCBP", "SDHA", "SDHB", "SEC11A", "SEC16A", "SEC22B", "SEC23A", "SEC23IP", "SEC24A", "SEC24B", "SEC24C", "SEC24D", "SEC31A", "SEC61A1", "SEC61B", "SEC61G", "SEH1L", "SEL1L", "SENP3", "SEPT2", "SEPT7", "SERPINB6", "SERPINH1", "SET", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SGPL1", "SGTA", "SH3GL1", "SHMT1", "SHMT2", "SHOC2", "SIGMAR1", "SIN3A", "SKIV2L", "SKIV2L2", "SKP1", "SKP2", "SLC12A2", "SLC16A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A17", "SLC25A19", "SLC25A20", "SLC25A26", "SLC25A32", "SLC25A4", "SLC25A44", "SLC25A5", "SLC25A6", "SLC27A2", "SLC27A4", "SLC29A1", "SLC30A5", "SLC35B2", "SLC38A2", "SLC3A2", "SLC4A7", "SLIT2", "SLK", "SMARCA4", "SMARCA5", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC6", "SMN1*", "SMNDC1", "SMPD4", "SMYD3", "SND1", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPC", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNW1", "SNX2", "SNX3", "SNX5", "SNX9", "SOD2", "SORT1", "SPAG9", "SPC25", "SPCS2", "SPEN", "SPPL2A", "SPR", "SPTAN1", "SPTBN1", "SPTBN2", "SPTLC1", "SPTLC2", "SQLE", "SQSTM1", "SRI", "SRM", "SRP14", "SRP54", "SRP68", "SRP72", "SRP9", "SRPK1", "SRPRA", "SRPRB", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF2", "SRSF3", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSNA1", "SSR1", "SSR4", "SSRP1", "STAG2", "STAM", "STAMBP", "STARD3", "STARD3NL", "STARD7", "STAT1", "STAT3", "STIP1", "STMN1", "STOM", "STOML2", "STRAP", "STT3A", "STUB1", "STX18", "STX4", "STX5", "STXBP3", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGT1", "SUN1", "SUPT16H", "SUPT5H", "SUPT6H", "SURF4", "SUZ12", "SYMPK", "SYNE2", "SYS1", "TACC3", "TACO1", "TAF15", "TAF6L", "TAGLN2", "TALDO1", "TARS", "TARS2", "TBC1D13", "TBC1D15", "TBC1D4", "TBCA", "TBCB", "TBCD", "TBCE", "TBL3", "TCEA1", "TCP1", "TDP2", "TDRKH", "TECR", "TERF2IP", "TEX10", "TEX264", "TFAM", "TFG", "TFRC", "THADA", "THOC1", "THOC2", "THOC3", "THOC6", "THOP1", "THRAP3", "THUMPD1", "TIAL1", "TIGAR", "TIMM13", "TIMM17A", "TIMM17B", "TIMM23", "TIMM44", "TIMM50", "TIMM8A", "TIMM8B", "TIMMDC1", "TJP1", "TK1", "TKT", "TLN1", "TMED10", "TMED2", "TMED5", "TMED7", "TMED9", "TMEM11", "TMOD3", "TMPO", "TMPO", "TMSB4X", "TNPO1", "TOLLIP", "TOM1", "TOMM20", "TOMM22", "TOMM40", "TOMM5", "TOMM70", "TOP1", "TOP2A", "TOP2B", "TOR1AIP1", "TP53", "TP53BP2", "TPD52", "TPI1", "TPM1", "TPM3", "TPM4", "TPP1", "TPP2", "TPR", "TPX2", "TRA2B", "TRAF2", "TRAM1", "TRAP1", "TRAPPC11", "TRAPPC3", "TRAPPC4", "TRAPPC5", "TRIM21", "TRIM25", "TRIM28", "TRIM33", "TRIO", "TRIP12", "TRMT10C", "TRMT6", "TSFM", "TSG101", "TSN", "TSNAX", "TSPO", "TSR1", "TTC26", "TTC37", "TTLL12", "TTYH3", "TUBB", "TUBB2A", "TUBB2B", "TUBB4A", "TUBB4B", "TUBB6", "TUBGCP2", "TUBGCP3", "TUFM", "TWF1", "TWF2", "TXLNA", "TXNDC5", "TXNL1", "TXNRD1", "TYMS", "U2AF2", "U2SURP", "UAP1", "UBA1", "UBA2", "UBA3", "UBA6", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2O", "UBE2Q1", "UBE2S", "UBE3C", "UBE4A", "UBR2", "UBR4", "UBTF", "UBXN7", "UCHL5", "UCK2", "UFD1", "UFL1", "UGCG", "UGDH", "UGGT1", "UGP2", "UHRF1", "UMPS", "UNC119B", "UPF1", "UQCR10", "UQCRC1", "UQCRC2", "UQCRQ", "UROD", "USO1", "USP10", "USP11", "USP14", "USP24", "USP28", "USP34", "USP39", "USP47", "USP48", "USP5", "USP7", "USP8", "USP9X", "UTP14A", "UTP15", "UTP18", "UTP20", "UTP4", "UTP6", "UTRN", "VAMP7", "VANGL1", "VAPA", "VAPB", "VARS1", "VAT1", "VBP1", "VCL", "VCP", "VDAC1", "VDAC2", "VDAC3", "VIM", "VKORC1L1", "VPS26A", "VPS29", "VPS33B", "VPS35", "VPS4A", "VPS4B", "VPS51", "VPS53", "VRK1", "WAPL", "WARS", "WBP11", "WDR1", "WDR12", "WDR18", "WDR3", "WDR33", "WDR36", "WDR4", "WDR43", "WDR5", "WDR6", "WDR61", "WDR75", "WDR77", "WDR91", "WFS1", "WIPI2", "WLS", "WTAP", "XAB2", "XPO1", "XPO5", "XPOT", "XRCC5", "XRCC6", "XRN2", "YARS", "YARS2", "YBX1", "YKT6", "YME1L1", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZC3H11A", "ZC3HAV1", "ZCCHC11", "ZFYVE16", "ZNF638", "ZW10"], "leading_proteins": ["ABCB1", "ABCD3", "ABHD10", "ABHD12", "ACAT2", "ACOT9", "ACOX1", "ACOX3", "ACP6", "ACTN1", "ADD1", "ADD3", "ADI1", "AK3", "AKT2", "ALDH3A2", "ALG1", "ALG12", "AMOT", "ANAPC1", "ANAPC10", "ANAPC5", "ANAPC7", "ANKLE2", "ANLN", "APLP2", "APOO", "APP", "ARV1", "ASAH1", "ASNA1", "ATP13A1", "ATP1A1", "ATP1B1", "ATP2A2", "ATP5F1", "ATP5L", "ATP6AP1", "ATP6AP2", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP7B", "B4GAT1", "BAG6", "BAIAP2", "BSG", "C19orf70", "C1QBP", "CALU", "CAMK1", "CAMK2G", "CANX", "CBL", "CBX2", "CBX3", "CBX5", "CCNB2", "CDC23", "CDC27", "CDC37", "CDK1", "CDX2", "CERS2", "CHKA", "CHST14", "CHUK", "CLCN3", "CLCN7", "COL4A3BP", "COLEC12", "COMT", "COQ3", "COX2", "COX5A", "CPD", "CPOX", "CPT2", "CRK", "CRTAP", "CSNK1A1", "CTNNB1", "CTNND1", "CTSA", "CTSB", "CTSC", "CUL1", "CXADR", "CYB5B", "CYB5R1", "CYB5R3", "CYFIP1", "CYP51A1", "DERL1", "DHCR24", "DHCR7", "DNASE2", "DSG2", "EHD1", "EIF2S1", "EMD", "ENDOD1", "EPHX1", "EPS15", "ERLIN1", "FAM49B", "FIS1", "FKBP14", "FLNC", "FLOT1", "FLOT2", "FN3KRP", "FUCA1", "FUCA2", "GAA", "GALNT1", "GALNT2", "GANAB", "GAPVD1", "GBA", "GDI1", "GDI2", "GET4", "GGH", "GLA", "GLB1", "GLG1", "GLUD1", "GM2A", "GNAI2", "GNPAT", "GNS", "GPAM", "GRB2", "GSK3B", "GUSB", "HADH", "HADHA", "HEXA", "HEXB", "HIF1AN", "HLA-A", "HLA-B", "HLA-C", "HMGB1", "HMOX1", "HMOX2", "HNRNPDL", "HNRNPF", "HNRNPH1", "HSD17B11", "HSD17B12", "HSD17B4", "ICMT", "IDH1", "IDH2", "IGF2R", "ITGB1", "ITM2C", "KDM1B", "KDSR", "KHSRP", "KIF23", "LAMP1", "LBR", "LGALS3BP", "LGMN", "LIPA", "LNPEP", "LPCAT3", "LPGAT1", "LSS", "LTA4H", "MAN2B1", "MANBA", "MARC1", "MBOAT7", "ME1", "MFN2", "MGST2", "MGST3", "MIF", "MINPP1", "MMGT1", "MOV10", "MTAP", "MTCH1", "MTX1", "NAGLU", "NCSTN", "NDC1", "NDUFB10", "NDUFB3", "NDUFB5", "NDUFS2", "NEK9", "NNT", "NPC1", "NPC2", "NUCB1", "NUP210", "NUP54", "OCLN", "OCRL", "OLA1", "OTUB1", "P3H1", "P4HB", "PDHB", "PDLIM7", "PEX14", "PEX19", "PGRMC1", "PGRMC2", "PITRM1", "PKMYT1", "PLA2G15", "PLCG1", "PLD3", "PLD6", "PLK1", "PMPCA", "POR", "PPP2R1B", "PPT1", "PPT2", "PRCP", "PRKAR1A", "PRKCSH", "PRKRA", "PRMT1", "PRMT5", "PSAP", "PSMA6", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMF1", "PTGES2", "PTGES3", "PXMP2", "RAB10", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB21", "RAB35", "RAB3GAP2", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RAB8A", "RACGAP1", "RAD23A", "RAD23B", "RALA", "RAP2B", "RBBP4", "RBMX", "RDH11", "RDH13", "RETSAT", "RNASET2", "RNF2", "RSU1", "RTN3", "SC5D", "SCARB1", "SCARB2", "SCCPDH", "SCO2", "SDCBP", "SEC11A", "SGPL1", "SKP1", "SLC12A2", "SLC16A1", "SLC1A5", "SLC25A10", "SLC25A15", "SLC25A20", "SLC25A26", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A2", "SLC29A1", "SLC30A5", "SLC35B2", "SLC38A2", "SLC3A2", "SLC4A7", "SNW1", "SORT1", "SPPL2A", "SPR", "SPTLC1", "SPTLC2", "SQSTM1", "SRPRB", "SSR1", "STAM", "STAMBP", "STARD3NL", "STARD7", "STOM", "STX5", "STXBP3", "SURF4", "SUZ12", "TAF15", "TFRC", "TIAL1", "TIMM17A", "TIMM17B", "TIMM23", "TIMM44", "TIMMDC1", "TJP1", "TMEM11", "TOMM20", "TOMM22", "TOMM5", "TP53", "TPP1", "TRAPPC11", "TRAPPC3", "TRAPPC4", "TRAPPC5", "TSPO", "TTYH3", "UBE2N", "UBE2S", "UGCG", "UQCR10", "UQCRQ", "VAMP7", "VANGL1", "VDAC1", "VDAC2", "VDAC3", "VPS33B", "WDR6", "YWHAE", "YWHAZ"]} \ No newline at end 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9.033677057044543e-06 +Sphingolipid metabolism overview 6 7 2.231202376453349 0.0256677266386049 4.0 7.951456310679611 1.305604070038762 0.1692072490812911 2.0060587839493125 1.5113078035984122 1.4254327231792938 0.2283290755268721 0.0017552448339215 1.0 0.1515272625734178 0.00062382482254 7.643588599556395e-06 +Sphingolipid metabolism integrated pathway 6 7 2.231202376453349 0.0256677266386049 4.058252427184466 8.101941747572816 1.3056837288293504 0.1731905617886817 2.1182299017960826 1.603786816240382 1.4154175704443392 0.233855234687812 0.0024486379328634 1.0 0.1677870330809631 0.0009779431698101 1.819255300619997e-05 +Degradation pathway of sphingolipids including diseases 4 7 2.194339874995922 0.0282109848332685 3.645631067961165 6.432038834951456 0.0687547082162972 0.1728701573933007 1.3368036576958324 0.5554170290527195 1.9109030412897592 0.2451148181788838 5.076244494186104e-06 8.586603742440297e-06 9.745982190989103e-07 9.327097249989188e-07 9.308926617220138e-07 +Cholesterol 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term", + "value": 9.193929173693085 +} \ No newline at end of file diff --git a/msigdb_wp/paths.json b/msigdb_wp/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..3f440ff4ce225b3bb09ecbacbdbf04d80e8924c7 --- /dev/null +++ b/msigdb_wp/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/msigdb_wp/fragment/C197/C197_val_log2fc"} \ No newline at end of file diff --git a/msigdb_wp/result.tsv b/msigdb_wp/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..83868b8bbe491b710622abc560be13259287f73c --- /dev/null +++ b/msigdb_wp/result.tsv @@ -0,0 +1,107 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Sphingolipid pathway 0.8513048526717581 2.7120634885619137 0.0066865784499894 0.9812855069576456 0.7634382845461659 10 Q13510,P04062,Q9Y5P4,O15269,Q06136,Q16739,Q96G23,O95470 8 +Sphingolipid metabolism in senescence 0.7967992500753285 2.6955980698918376 0.0070262391280531 0.98472085349812 0.7634382845461659 12 Q13510,P04062,P16278,Q06136,Q16739,Q96G23 6 +Glycosaminoglycan degradation 0.9586808188021196 2.506940660823344 0.0121781154130335 0.9993010669591048 0.7634382845461659 6 P16278,P08236,P15586,P54802,P06865 5 +Sphingolipid metabolism overview 0.8547591960561202 2.231202376453349 0.0256677266386049 0.9999997989503668 0.7634382845461659 7 Q13510,O15269,Q06136,Q16739,Q96G23,O95470 6 +Sphingolipid metabolism integrated pathway 0.8547591960561202 2.231202376453349 0.0256677266386049 0.9999997989503668 0.7634382845461659 7 Q13510,O15269,Q06136,Q16739,Q96G23,O95470 6 +Degradation pathway of sphingolipids including diseases 0.8460654227295313 2.194339874995922 0.0282109848332685 0.9999999573236305 0.7634382845461659 7 P06280,P16278,P17900,P06865 4 +Cholesterol biosynthesis with skeletal dysplasias 0.8598738302831483 2.1113114567912517 0.034745549941124 0.9999999992191012 0.7634382845461659 6 Q16850,Q9UBM7,O75845,Q15392 4 +Nephrotic syndrome 0.6890653078635378 2.0884282063866846 0.0367592253175472 0.999999999773655 0.7634382845461659 11 Q14108,O75844,O00592 3 +Metabolism of spingolipids in er and golgi apparatus 0.8799242424242455 1.9933872999251865 0.046219053474692 0.99999999999935 0.7634382845461659 4 Q16739,O95470,Q06136 3 +Mitochondrial complex i assembly model oxphos system 0.6005513904128873 1.9559612120441097 0.050469723533429 0.999999999999954 0.7634382845461659 20 O96000,Q96CU9,O75306,O43676,Q9NPL8 5 +Oxidation by cytochrome p450 0.8169309836255264 1.9336070304327333 0.0531614622144485 0.9999999999999916 0.7634382845461659 6 Q16850,Q6UW02,P16435,O43169 4 +7oxoc and 7betahc pathways 0.7205113787678243 1.929793604340283 0.053632416271214 0.9999999999999936 0.7634382845461659 9 P61916,Q9UBM7,O15118 3 +Mitochondrial complex iii assembly 0.7433590571085856 1.8858741572147597 0.0593119147446905 0.9999999999999998 0.7634382845461659 8 O14949,P31930,Q9UDW1,Q9Y276,Q9BRT2,Q6DKK2 6 +Ketogenesis and ketolysis 0.8501429169750471 1.87220629252731 0.0611780688726741 1.0 0.7634382845461659 4 P23786,O43772 2 +Vitamin d metabolism 0.9158597544969076 1.8156328272951048 0.0694267144742406 1.0 0.7634382845461659 3 Q9UBM7 1 +1q211 copy number variation syndrome 0.7780058051423601 1.769610332276462 0.0767920764473875 1.0 0.7634382845461659 6 Q16625,Q07157,Q9NPH0 3 +Ferroptosis 0.5648278842985469 1.7313864322672072 0.0833828648719856 1.0 0.7634382845461659 22 P45880,P09601,P02786,Q15758,P37268,Q96QD8,Q6P1A2,P08195,Q9Y277,P16435 10 +Familial partial lipodystrophy fpld 0.7387213070698222 1.7262762544671144 0.0842977251770999 1.0 0.7634382845461659 7 O75844 1 +Overlap between signal transduction pathways contributing to lmna laminopathies 0.6010882150293441 1.6998579066565205 0.0891576562410967 1.0 0.7634382845461659 13 O75844,O60725,P55209 3 +Cholesterol metabolism with bloch and kandutschrussell pathways 0.5479421332564162 1.628008838670275 0.1035230116377849 1.0 0.7634382845461659 19 O75845,Q15392,Q16850,Q14739,P48449,Q9BWD1,Q9UBM7 7 +Ppar signaling pathway 0.579093832929302 1.5732198521874567 0.1156679200577766 1.0 0.7634382845461659 13 P23786,Q15067,O14975 3 +Inclusion body myositis 0.95457986373959 1.551232931533065 0.120845872900082 1.0 0.7634382845461659 2 P05067 1 +Glycerophospholipid biosynthetic pathway 0.735126942023497 1.545174442368973 0.1223040745236572 1.0 0.7634382845461659 5 O15228,O00116,P48651,Q9HCL2 4 +Influence of laminopathies on wnt signaling 0.6387540799922091 1.526450425851323 0.1268977275967282 1.0 0.7634382845461659 9 O75844,O60725 2 +Estrogen receptor pathway 0.8433802640367747 1.524941040921986 0.127273804086603 1.0 0.7634382845461659 3 Q15067 1 +Nonalcoholic fatty liver disease 0.5198380114389691 1.5143404093956778 0.129939524615231 1.0 0.7634382845461659 39 O96000,O14949,P14406,P54619,Q9UDW1,O43674,O75306,P00403,P05198,O43676,P20674,Q96GC9 12 +Photodynamic therapyinduced nfe2l2 nrf2 survival signaling 0.7608294626275077 1.5022245696179943 0.1330391215442252 1.0 0.7634382845461659 4 P09601,P07099 2 +Adipogenesis 0.564564204673933 1.488720096981406 0.1365610906202115 1.0 0.7634382845461659 13 P43490 1 +Sarscov2 and covid19 pathway 0.8292950601094702 1.4681223964884806 0.1420709789670935 1.0 0.7634382845461659 3 Q8WTV0 1 +Kennedy pathway from sphingolipids 0.7153818180709203 1.4604515650470322 0.1441660098252506 1.0 0.7634382845461659 5 P35790,O95470 2 +Copper homeostasis 0.704677272582376 1.4538774691317098 0.1459802804376868 1.0 0.7634382845461659 6 P35670,P05067 2 +Statin inhibition of cholesterol production 0.8246876183264038 1.449526446686799 0.1471906201762864 1.0 0.7634382845461659 3 Q14534,Q8WTV0 2 +Mitochondrial complex iv assembly 0.6497313346870971 1.4444566194674984 0.1486105739372023 1.0 0.7634382845461659 8 O43819,P20674,P14406 3 +Proteoglycan biosynthesis 0.911430734292202 1.374646752447794 0.1692409867080286 1.0 0.7719992701373923 2 Q8TB61 1 +Progeriaassociated lipodystrophy 0.6030090007703717 1.345489178755721 0.1784673135337553 1.0 0.7744992481009751 9 O75844 1 +Eicosanoid synthesis 0.8970476911430738 1.3159637899007122 0.1881861964772366 1.0 0.7773708790913013 2 Q9H7Z7 1 +Ebola virus infection in host 0.4984600687141104 1.314954144467627 0.1885253141020526 1.0 0.7773708790913013 34 P01889,P07858,P61916,P05198,P04439,Q07021,O15118,P10321 8 +S1p receptor signal transduction 0.6273079665251401 1.2185448859878338 0.2230169784243103 1.0 0.8092186958814702 7 Q13510,P04899 2 +Allograft rejection 0.5759171853755662 1.2069488380407016 0.2274518477680798 1.0 0.8092186958814702 9 P04439,P01889,P10321 3 +Cytosine methylation 0.6561562653584398 1.2044869088224253 0.2284014389179858 1.0 0.8092186958814702 5 P48735 1 +Tryptophan metabolism 0.5138614804545982 1.1893233034652118 0.2343124686243196 1.0 0.8110378118937284 13 P49189,Q16836,Q15392 3 +Glycerolipids and glycerophospholipids 0.7461378009841668 1.133283414472787 0.2570952544461187 1.0 0.8444163815066473 3 Q9HCL2 1 +Oxysterols derived from cholesterol 0.601517148736006 1.0991278187965563 0.271712317342915 1.0 0.8709481307262086 7 Q9UBM7,O14975 2 +Camkk2 pathway 0.5103274581909012 1.093513596279487 0.2741683627022604 1.0 0.8740959090453787 11 P09601,O00429,Q13501,Q14012,Q9Y3D6 5 +Primary focal segmental glomerulosclerosis fsgs 0.4753052612642827 1.033641825940302 0.3013036383656799 1.0 0.8976502106413804 15 Q14108 1 +Mrna protein and metabolite inducation pathway by cyclosporin a 0.8255109765329283 1.027852538931729 0.304019197838878 1.0 0.8976502106413804 2 P08195 1 +Cholesterol biosynthesis pathway 0.4968938799746125 1.015892228733817 0.3096807099329486 1.0 0.8976502106413804 11 Q16850,P48449,Q9UBM7,O75845 4 +Apoptosisrelated network due to altered notch3 in ovarian cancer 0.4808122773251098 0.9915224521402896 0.3214305345996731 1.0 0.8976502106413804 13 P05067 1 +15q112 copy number variation syndrome 0.6371943830962395 0.984294220547024 0.3249708703517209 1.0 0.8976502106413804 4 Q06787 1 +Proximal tubule transport 0.5124578198353386 0.9836981715241826 0.3252639391262273 1.0 0.8976502106413804 10 P05026,P08183,P08195 3 +Autosomal recessive osteopetrosis pathways 0.8092354277062819 0.9637557696676924 0.3351683865674277 1.0 0.9047587207145849 2 P51798 1 +Mitochondrial long chain fatty acid betaoxidation 0.4815266695838115 0.9604863432425074 0.3368105010253313 1.0 0.9047587207145849 12 P23786,O43772 2 +Alzheimers disease and mirna effects 0.3616624750294258 0.9279413877127128 0.3534379740453768 1.0 0.913962577239998 82 P12235,P05067,O14654,P21796,Q96IX5,P20618,P45880,P16615,P49721,Q96GC9,P28074,P05198,P49720,P28070,O95197,Q9Y277,Q99436,P12236,P28072,Q92542 20 +Nuclear receptors in lipid metabolism and toxicity 0.7702498107494293 0.8137757725277939 0.4157734167927387 1.0 0.9569232825071414 2 P08183 1 +Photodynamic therapyinduced hif1 survival signaling 0.4806366911452499 0.810747190473484 0.4175108671058476 1.0 0.9569232825071414 10 Q9NWT6 1 +Type i collagen synthesis in the context of osteogenesis imperfecta 0.4736102338592042 0.7727613936738118 0.4396636052191938 1.0 0.9569232825071414 10 P13674,O75718,Q32P28 3 +Alzheimers disease 0.3460994935308921 0.7717159514466894 0.4402826809469133 1.0 0.9569232825071414 80 P20618,P45880,P05067,P21796,P49720,P49721,P28070,Q92542,O95197,Q9Y277 10 +Network map of sarscov2 signaling pathway 0.4194187600774031 0.7644276653789506 0.4446124274647731 1.0 0.9569232825071414 22 P07858 1 +Intracellular trafficking proteins involved in cmt neuropathy 0.5264898084959515 0.7536101444956751 0.4510833511014573 1.0 0.9569232825071414 7 O95140,Q9NR77,P07196 3 +Fatty acid betaoxidation 0.418740627460906 0.7507319830127022 0.4528139708131755 1.0 0.9569232825071414 17 P23786,O43772 2 +Metapathway biotransformation phase i and ii 0.4140082068682725 0.7414732728730882 0.458406531374345 1.0 0.9569232825071414 20 Q86UY6,P21964,Q8NCH0,Q16850,Q99735,Q6UW02 6 +Fluoropyrimidine activity 0.4421470359756315 0.7292433009530048 0.4658528482711568 1.0 0.9569232825071414 12 Q92820 1 +Phase i biotransformations non p450 0.6229237916136698 0.6599427652834926 0.5092905591340728 1.0 0.9731360680659914 3 P38571 1 +Electron transport chain oxphos system in mitochondria 0.4021153647534896 0.6417783993568873 0.5210170766708175 1.0 0.9731360680659914 43 O96000,P12235,P12236,P24539,O14949,O43674,Q9UDW1,P14406,O75306,P00403,O43676,P20674,O75964 13 +Proteasome degradation 0.4032055166413242 0.6371225788271346 0.52404500241781 1.0 0.9731360680659914 41 P20618,P01889,P04439,P49720,P49721,P10321,P28070 7 +Aryl hydrocarbon receptor pathway wp2873 0.5401013339341012 0.5973902445596764 0.5502468653954078 1.0 0.9731360680659914 4 Q15185 1 +Oxidative phosphorylation 0.3957294719612862 0.5762094699005921 0.5644736050700521 1.0 0.9735044716175424 27 O96000,O75787,O75306,Q15904,O75964 5 +Interactome of polycomb repressive complex 2 prc2 0.5027642679575495 0.5575820635207884 0.5771298072820112 1.0 0.9735044716175424 5 Q9Y2W1,Q15022 2 +Nocgmppkg mediated neuroprotection 0.4784398043118412 0.5399625564221503 0.5892228551318124 1.0 0.9735044716175424 7 P30536 1 +Calcium regulation in cardiac cells 0.3826576102497837 0.5253622719347406 0.5993313755671128 1.0 0.9735044716175424 21 P05026,P10644,Q14012,P16615,P04899 5 +Regulation of apoptosis by parathyroid hormonerelated protein 0.6782740348220997 0.4918112134712309 0.6228528086363083 1.0 0.9735044716175424 2 P49841 1 +Hepatitis b infection 0.3723941839806898 0.4855685106441831 0.6272731271466911 1.0 0.9735044716175424 18 Q7Z434,Q15904,Q9Y277 3 +Transcriptional activation by nrf2 in response to phytochemicals 0.5085784046867619 0.4826953343175175 0.6293120765496534 1.0 0.9735044716175424 4 P09601 1 +Regulation of wnt bcatenin signaling by small molecule compounds 0.5615297235895467 0.4525966429199455 0.6508392165757415 1.0 0.9735044716175424 3 P49841,P35222 2 +Ccl18 signaling pathway 0.4356958140982309 0.4217692757039115 0.673193433733023 1.0 0.9735044716175424 8 Q96GC9,P00403,P07196 3 +Antiviral and antiinflammatory effects of nrf2 on sarscov2 pathway 0.4640494807157749 0.410894896379925 0.681149604884272 1.0 0.9735044716175424 5 P09601 1 +Interactions between loxl4 and oxidative stress pathway 0.65064345193035 0.4080084500835275 0.6832674711688238 1.0 0.9735044716175424 2 Q9BQ95 1 +Mecp2 and associated rett syndrome 0.3685711549526822 0.3794486011204389 0.7043547656818123 1.0 0.9813278754150384 15 P35637,P52597 2 +Disruption of postsynaptic signaling by cnv 0.4526304351793999 0.3763963428591303 0.7066222644219586 1.0 0.9813278754150384 6 Q7L576,Q06787 2 +Preimplantation embryo 0.4232643968597754 0.3678916150054189 0.7129540527174385 1.0 0.9836321855734468 8 Q99729,Q92945 2 +Amyotrophic lateral sclerosis als 0.4267965056940813 0.326783751181997 0.7438314500027836 1.0 0.9906505715727312 7 Q9BUN8,P07196 2 +Fragile x syndrome 0.3631893795612081 0.3262251773595916 0.74425399368981 1.0 0.9906505715727312 34 P10644,P53985,P05067,Q14012,P51648,Q7L576,Q06787 7 +Methionine de novo and salvage pathway 0.4200946663742343 0.3009862972671998 0.763424943514996 1.0 1.0 7 Q13126 1 +Fluoroacetic acid toxicity 0.4294115878866799 0.291701630006798 0.7705147628349933 1.0 1.0 5 P49189 1 +Hepatitis c and hepatocellular carcinoma 0.4023280247597544 0.280893806483591 0.7787918511989773 1.0 1.0 8 O00592 1 +16p112 distal deletion syndrome 0.408797876374666 0.2587140833257749 0.7958558525096828 1.0 1.0 7 P62993,Q8WWM7,Q9H2V7,Q99873,P49411,P20339 6 +Hedgehog signaling pathway wp47 0.485800833017784 0.2465414155518651 0.8052631486147854 1.0 1.0 3 O00422,Q2M1P5 2 +Mammalian disorder of sexual development 0.5579106737320133 0.1891980804112913 0.8499375721045308 1.0 1.0 2 P35222 1 +Hair follicle development organogenesis part 2 of 3 0.4524801211662234 0.1784295292375765 0.8583856604064604 1.0 1.0 3 P05556,P35222 2 +Mitochondrial immune response to sarscov2 0.3807356844899512 0.1612033112165767 0.8719332732541045 1.0 1.0 7 Q99623,O94826,Q9Y276,Q7Z434,P35232,Q9BQ95 6 +Ectoderm differentiation 0.3170244731688409 0.149184933014197 0.8814077086582355 1.0 1.0 18 P16278,O00592 2 +Nsp1 from sarscov2 inhibits translation initiation in the host cell 0.3305818890642761 0.1270844011520863 0.8988735974302728 1.0 1.0 12 P55010 1 +Mitochondrial complex ii assembly 0.5045420136260312 0.1123108824854929 0.9105769134218508 1.0 1.0 2 P31040 1 +Transcription factors regulate mirnas related to cardiac hypertrophy 0.5030280090840219 0.1106390117546079 0.911902610473772 1.0 1.0 2 P31751 1 +Extracellular vesiclemediated signaling in recipient cells 0.4909159727479079 0.0982041022746612 0.9217702250683212 1.0 1.0 2 P35222 1 +Pi3kaktmtor vitd3 signaling 0.3565744600227377 0.0936376591947597 0.925396993313618 1.0 1.0 5 Q04206,P42345,P49841,P00338 4 +Neuroinflammation 0.3583333333333368 0.0910242532395033 0.9274733197518128 1.0 1.0 4 O15111,P42345,P00403 3 +Vitamin dsensitive calcium signaling in depression 0.3523172009502663 0.0846754149280525 0.932519441801018 1.0 1.0 5 Q8NB78 1 +Nanomaterial induced apoptosis 0.3693640954497619 0.0728359044163549 0.941936699229548 1.0 1.0 3 O95831 1 +Hair follicle development cytodifferentiation part 3 of 3 0.4523088569265595 0.0687470743945248 0.9451909468646542 1.0 1.0 2 P35222 1 +Microrna network associated with chronic lymphocytic leukemia 0.4477668433005207 0.0661843711652484 0.9472310394940416 1.0 1.0 2 Q07820 1 +Supression of hmgb1 mediated inflammation by thbd 0.358197652404381 0.0649190675688206 0.9482384388928348 1.0 1.0 3 O15111,P09429 2 +Praderwilli and angelman syndrome 0.3521607278241008 0.0610331402475933 0.9513328161417052 1.0 1.0 6 P06400,P11802,P04637,Q15154,Q7L576 5 +Ciliary landscape 0.2906194032006478 0.0604456078379534 0.9518007352367264 1.0 1.0 84 P10619,P27105,P06280,P16278 4 +T cell receptor and costimulatory signaling 0.3162878787878906 0.0401872191821207 0.967943867014842 1.0 1.0 4 P48729,P49841,P19174 3 +Burn wound healing 0.3238528631020115 0.0039403725918802 0.9968560456809168 1.0 1.0 7 Q99439,P50454,P08670,P04637,P09429,P07737 6 diff --git a/msigdb_wp/selections.json b/msigdb_wp/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..77f5a7b4c464acc6abac835f199e63dce7b7af38 --- /dev/null +++ b/msigdb_wp/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["15q112 copy number variation syndrome", "15q133 copy number variation syndrome", "16p112 distal deletion syndrome", "16p112 proximal deletion syndrome", "1q211 copy number variation syndrome", "22q112 copy number variation syndrome", "3q29 copy number variation syndrome", "4hydroxytamoxifen dexamethasone and retinoic acids regulation of p27 expression", "7oxoc and 7betahc pathways", "7q1123 copy number variation syndrome", "Ace inhibitor pathway", "Acetylcholine synthesis", "Acquired partial lipodystrophy barraquersimons syndrome", "Activation of nlrp3 inflammasome by sarscov2", "Acute viral myocarditis", "Adipogenesis", "Aerobic glycolysis", "Aflatoxin b1 metabolism", "Agerage pathway", "Airway smooth muscle cell contraction", "Alanine and aspartate metabolism", "Allograft rejection", "Alpha 6 beta 4 signaling pathway", "Altered glycosylation of muc1 in tumor microenvironment", "Alternative pathway of fetal androgen synthesis", "Alzheimers disease", "Alzheimers disease and mirna effects", "Amino acid metabolism", "Amino acid metabolism pathway excerpt histidine catabolism extension", "Ampactivated protein kinase ampk signaling", "Amyotrophic lateral sclerosis als", "Androgen receptor signaling pathway", "Angiogenesis", "Angiopoietinlike protein 8 regulatory pathway", "Angiotensin ii receptor type 1 pathway", "Antiviral and antiinflammatory effects of nrf2 on sarscov2 pathway", "Apoe and mir146 in inflammation and atherosclerosis", "Apoptosis", "Apoptosis modulation and signaling", "Apoptosis modulation by hsp70", "Apoptosisrelated network due to altered notch3 in ovarian cancer", "Arachidonate epoxygenase epoxide hydrolase", "Arrhythmogenic right ventricular cardiomyopathy", "Aryl hydrocarbon receptor pathway wp2586", "Aryl hydrocarbon receptor pathway wp2873", "Aspirin and mirnas", "Atm signaling in development and disease", "Atm signaling pathway", "Atr signaling", "Autophagy", "Autosomal recessive osteopetrosis pathways", "B cell receptor signaling pathway", "Base excision repair", "Bdnftrkb signaling", "Benzene metabolism", "Benzoapyrene metabolism", "Bile acids synthesis and enterohepatic circulation", "Biogenic amine synthesis", "Biomarkers for pyrimidine metabolism disorders", "Biomarkers for urea cycle disorders", "Biotin metabolism including iems", "Bladder cancer", "Bmp2wnt4foxo1 pathway in primary endometrial stromal cell differentiation", "Brainderived neurotrophic factor bdnf signaling pathway", "Breast cancer pathway", "Burn wound healing", "Calcium regulation in cardiac cells", "Caloric restriction and aging", "Camkk2 pathway", "Cancer immunotherapy by ctla4 blockade", "Cancer immunotherapy by pd1 blockade", "Cannabinoid receptor signaling", "Canonical and noncanonical notch signaling", "Canonical nfkb pathway", "Cardiac hypertrophic response", "Cardiac progenitor differentiation", "Ccl18 signaling pathway", "Cell cycle", "Cell differentiation expanded index", "Cell differentiation index", "Cell migration and invasion through p75ntr", "Cells and molecules involved in local acute inflammatory response", "Celltype dependent selectivity of cck2r signaling", "Cellular proteostasis", "Cerebral organic acidurias including diseases", "Chemokine signaling pathway", "Cholesterol biosynthesis pathway", "Cholesterol biosynthesis with skeletal dysplasias", "Cholesterol metabolism with bloch and kandutschrussell pathways", "Chromosomal and microsatellite instability in colorectal cancer", "Ciliary landscape", "Ciliopathies", "Circadian rhythm genes", "Classical pathway of steroidogenesis with glucocorticoid and mineralocorticoid metabolism", "Clear cell renal cell carcinoma pathways", "Codeine and morphine metabolism", "Cohesin complex cornelia de lange syndrome", "Common pathways underlying drug addiction", "Complement and coagulation cascades", "Complement system", "Complement system in neuronal development and plasticity", "Congenital generalized lipodystrophy cgl", "Constitutive androstane receptor pathway", "Control of immune tolerance by vasoactive intestinal peptide", "Copper homeostasis", "Cori cycle", "Corticotropinreleasing hormone signaling pathway", "Cysteine and methionine catabolism", "Cytoplasmic ribosomal proteins", "Cytosine methylation", "Cytosolic dnasensing pathway", "Ddx1 as a regulatory component of the drosha microprocessor", "Degradation pathway of sphingolipids including diseases", "Development of pulmonary dendritic cells and macrophage subsets", "Development of ureteric collection system", "Disorders of folate metabolism and transport", "Disruption of postsynaptic signaling by cnv", "Dna damage response", "Dna damage response only atm dependent", "Dna irdamage and cellular response via atr", "Dna irdouble strand breaks and cellular response via atm", "Dna mismatch repair", "Dna repair pathways full network", "Dna replication", "Dopamine metabolism", "Dopaminergic neurogenesis", "Drug induction of bile acid pathway", "Dual hijack model of vif in hiv infection", "Ebola virus infection in host", "Ebsteinbarr virus lmp1 signaling", "Ectoderm differentiation", "Effect of progerin on genes involved in hutchinsongilford progeria syndrome", "Egfegfr signaling pathway", "Egfr tyrosine kinase inhibitor resistance", "Eicosanoid metabolism via cyclooxygenases cox", "Eicosanoid metabolism via cytochrome p450 monooxygenases pathway", "Eicosanoid metabolism via lipooxygenases lox", "Eicosanoid synthesis", "Electron transport chain oxphos system in mitochondria", "Embryonic stem cell pluripotency pathways", "Endochondral ossification", "Endochondral ossification with skeletal dysplasias", "Endoderm differentiation", "Endometrial cancer", "Endoplasmic reticulum stress response in coronavirus infection", "Endothelin pathways", "Energy metabolism", "Envelope proteins and their potential roles in edmd physiopathology", "Epithelial to mesenchymal transition in colorectal cancer", "Epo receptor signaling", "Erbb signaling pathway", "Erk pathway in huntingtons disease", "Estrogen metabolism", "Estrogen receptor pathway", "Estrogen signaling pathway", "Ethanol effects on histone modifications", "Ethanol metabolism production of ros by cyp2e1", "Eukaryotic transcription initiation", "Exerciseinduced circadian regulation", "Exrna mechanism of action and biogenesis", "Extracellular vesiclemediated signaling in recipient cells", "Extracellular vesicles in the crosstalk of cardiac cells", "Factors and pathways affecting insulinlike growth factor igf1akt signaling", "Familial hyperlipidemia type 1", "Familial hyperlipidemia type 2", "Familial hyperlipidemia type 3", "Familial hyperlipidemia type 4", "Familial hyperlipidemia type 5", "Familial partial lipodystrophy fpld", "Farnesoid x receptor pathway", "Fas ligand pathway and stress induction of heat shock proteins", "Fatty acid betaoxidation", "Fatty acid biosynthesis", "Fatty acid omegaoxidation", "Fatty acid transporters", "Fbxl10 enhancement of maperk signaling in diffuse large bcell lymphoma", "Ferroptosis", "Fgfr3 signaling in chondrocyte proliferation and terminal differentiation", "Fibrin complement receptor 3 signaling pathway", "Fluoroacetic acid toxicity", "Fluoropyrimidine activity", "Focal adhesion", "Focal adhesion pi3kaktmtorsignaling pathway", "Folate metabolism", "Folatealcohol and cancer pathway hypotheses", "Follicle stimulating hormone fsh signaling pathway", "Foxa2 pathway", "Foxp3 in covid19", "Fragile x syndrome", "Fto obesity variant mechanism", "G protein signaling pathways", "G1 to s cell cycle control", "G13 signaling pathway", "Gaba metabolism aka ghb", "Gaba receptor signaling", "Galanin receptor pathway", "Gammaglutamyl cycle for the biosynthesis and degradation of glutathione including diseases", "Gastric cancer network 1", "Gastric cancer network 2", "Gastrin signaling pathway", "Gdnfret signaling axis", "Genes controlling nephrogenesis", "Genes related to primary cilium development based on crispr", "Genes targeted by mirnas in adipocytes", "Glial cell differentiation", "Glioblastoma signaling pathways", "Glucocorticoid receptor pathway", "Glucuronidation", "Glutathione metabolism", "Glycerolipids and glycerophospholipids", "Glycerophospholipid biosynthetic pathway", "Glycogen synthesis and degradation", "Glycolysis and gluconeogenesis", "Glycolysis in senescence", "Glycosaminoglycan degradation", "Glycosylation and related congenital defects", "Gpcrs class a rhodopsinlike", "Gpr40 pathway", "H19 action rbe2f1 signaling and cdkbetacatenin activity", "Hair follicle development cytodifferentiation part 3 of 3", "Hair follicle development organogenesis part 2 of 3", "Head and neck squamous cell carcinoma", "Heart development", "Hedgehog signaling pathway wp4249", "Hedgehog signaling pathway wp47", "Hematopoietic stem cell gene regulation by gabp alphabeta complex", "Heme biosynthesis", "Hepatitis b infection", "Hepatitis c and hepatocellular carcinoma", "Hepatocyte growth factor receptor signaling", "Hereditary leiomyomatosis and renal cell carcinoma pathway", "Hif1a and pparg regulation of glycolysis", "Hijack of ubiquitination by sarscov2", "Hippo signaling regulation pathways", "Hippomerlin signaling dysregulation", "Hippoyap signaling pathway", "Histone modifications", "Homologous recombination", "Hostpathogen interaction of human coronaviruses apoptosis", "Hostpathogen interaction of human coronaviruses autophagy", "Hostpathogen interaction of human coronaviruses interferon induction", "Hostpathogen interaction of human coronaviruses mapk signaling", "Hypertrophy model", "Hypothesized pathways in pathogenesis of cardiovascular disease", "Id signaling pathway", "Il1 signaling pathway", "Il10 antiinflammatory signaling pathway", "Il17 signaling pathway", "Il18 signaling pathway", "Il2 signaling pathway", "Il3 signaling pathway", "Il4 signaling pathway", "Il5 signaling pathway", "Il6 signaling pathway", "Il7 signaling pathway", "Il9 signaling pathway", "Imatinib and chronic myeloid leukemia", "Immune response to tuberculosis", "Inclusion body myositis", "Influence of laminopathies on wnt signaling", "Inhibition of exosome biogenesis and secretion by manumycin a in crpc cells", "Initiation of transcription and translation elongation at the hiv1 ltr", "Insulin signaling", "Insulin signaling in adipocytes diabetic condition", "Insulin signaling in adipocytes normal condition", "Integrated cancer pathway", "Integrinmediated cell adhesion", "Interactions between immune cells and micrornas in tumor microenvironment", "Interactions between loxl4 and oxidative stress pathway", "Interactome of polycomb repressive complex 2 prc2", "Interferon type i signaling pathways", "Interleukin1 il1 structural pathway", "Interleukin1 induced activation of nfkb", "Interleukin11 signaling pathway", "Intracellular trafficking proteins involved in cmt neuropathy", "Intraflagellar transport proteins binding to dynein", "Irinotecan pathway", "Iron metabolism in placenta", "Joubert syndrome", "Kallmann syndrome", "Kennedy pathway from sphingolipids", "Ketogenesis and ketolysis", "Ketone bodies synthesis and degradation", "Kininkallikrein pathway", "Kisspeptinkisspeptin receptor system in the ovary", "Kit receptor signaling pathway", "Krebs cycle disorders", "Kynurenine pathway and links to cell senescence", "Leptin and adiponectin", "Leptin signaling pathway", "Leptininsulin signaling overlap", "Leukocyteintrinsic hippo pathway functions", "Lipid metabolism pathway", "Liver x receptor pathway", "Lncrna in canonical wnt signaling and colorectal cancer", "Lncrnamediated mechanisms of therapeutic resistance", "Ltf danger signal response pathway", "Lung fibrosis", "Male infertility", "Malignant pleural mesothelioma", "Mammalian disorder of sexual development", "Mammary gland development pathway embryonic development stage 1 of 4", "Mammary gland development pathway involution stage 4 of 4", "Mammary gland development pathway pregnancy and lactation stage 3 of 4", "Mammary gland development pathway puberty stage 2 of 4", "Map3k1 role in promoting and blocking gonadal determination", "Mapk and nfkb signaling pathways inhibited by yersinia yopj", "Mapk cascade", "Mapk pathway in congenital thyroid cancer", "Mapk signaling pathway", "Matrix metalloproteinases", "Mbdnf and probdnf regulation of gaba neurotransmission", "Measles virus infection", "Mechanoregulation and pathology of yaptaz via hippo and nonhippo mechanisms", "Mecp2 and associated rett syndrome", "Melanoma", "Melatonin metabolism and effects", "Mesodermal commitment pathway", "Met in type 1 papillary renal cell carcinoma", "Metabolic pathway of ldl hdl and tg including diseases", "Metabolic reprogramming in colon cancer", "Metabolism of spingolipids in er and golgi apparatus", "Metapathway biotransformation phase i and ii", "Metastatic brain tumor", "Methionine de novo and salvage pathway", "Methionine metabolism leading to sulfur amino acids and related disorders", "Methylation pathways", "Mevalonate arm of cholesterol biosynthesis pathway", "Mevalonate pathway", "Mfap5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement", "Mfap5mediated ovarian cancer cell motility and invasiveness", "Microglia pathogen phagocytosis pathway", "Microrna for targeting cancer growth and vascularization in glioblastoma", "Microrna network associated with chronic lymphocytic leukemia", "Micrornas in cardiomyocyte hypertrophy", "Microtubule cytoskeleton regulation", "Mir124 predicted interactions with cell cycle and differentiation", "Mir517 relationship with arcn1 and usp1", "Mirna biogenesis", "Mirna regulation of dna damage response", "Mirna regulation of p53 pathway in prostate cancer", "Mirna regulation of prostate cancer signaling pathways", "Mirnas involved in dna damage response", "Mirnas involvement in the immune response in sepsis", "Mitochondrial complex i assembly model oxphos system", "Mitochondrial complex ii assembly", "Mitochondrial complex iii assembly", "Mitochondrial complex iv assembly", "Mitochondrial fatty acid synthesis pathway", "Mitochondrial gene expression", "Mitochondrial immune response to sarscov2", "Mitochondrial long chain fatty acid betaoxidation", "Modulators of tcr signaling and t cell activation", "Monoamine transport", "Mrna processing", "Mrna protein and metabolite inducation pathway by cyclosporin a", "Mthfr deficiency", "Myd88 distinct inputoutput pathway", "Myometrial relaxation and contraction pathways", "Nad biosynthetic pathways", "Nad metabolism", "Nad metabolism in oncogeneinduced senescence and mitochondrial dysfunctionassociated senescence", "Nad metabolism sirtuins and aging", "Nanomaterial induced apoptosis", "Nanomaterialinduced inflammasome activation", "Nanoparticle triggered autophagic cell death", "Nanoparticle triggered regulated necrosis", "Nanoparticlemediated activation of receptor signaling", "Ncrnas involved in stat3 signaling in hepatocellular carcinoma", "Ncrnas involved in wnt signaling in hepatocellular carcinoma", "Neovascularisation processes", "Nephrogenesis", "Nephrotic syndrome", "Netrinunc5b signaling pathway", "Network map of sarscov2 signaling pathway", "Neural crest cell migration during development", "Neural crest cell migration in cancer", "Neural crest differentiation", "Neurodegeneration with brain iron accumulation nbia subtypes pathway", "Neuroinflammation", "Neuroinflammation and glutamatergic signaling", "Nicotine effect on dopaminergic neurons", "Nipbl role in dna damage cornelia de lange syndrome", "Nitric oxide metabolism in cystic fibrosis", "Nocgmppkg mediated neuroprotection", "Nodlike receptor nlr signaling pathway", "Nonalcoholic fatty liver disease", "Nongenomic actions of 125 dihydroxyvitamin d3", "Nonhomologous end joining", "Nonsmall cell lung cancer", "Notch signaling", "Notch signaling pathway", "Notch1 regulation of endothelial cell calcification", "Novel intracellular components of rigilike receptor rlr pathway", "Nrf2 pathway", "Nrf2are regulation", "Nrp1triggered signaling pathways in pancreatic cancer", "Nsp1 from sarscov2 inhibits translation initiation in the host cell", "Nuclear receptors in lipid metabolism and toxicity", "Nuclear receptors metapathway", "Nucleotide excision repair", "Nucleotide excision repair in xeroderma pigmentosum", "Nucleotide metabolism", "Nucleotidebinding oligomerization domain nod pathway", "Oligodendrocyte specification and differentiation leading to myelin components for cns", "Omega3 omega6 fatty acid synthesis", "Omega9 fatty acid synthesis", "Oncostatin m signaling pathway", "Onecarbon metabolism", "Onecarbon metabolism and related pathways", "Orexin receptor pathway", "Osteoblast differentiation and related diseases", "Osteoclast signaling", "Osteopontin signaling", "Osx and mirnas in tooth development", "Ovarian infertility", "Overlap between signal transduction pathways contributing to lmna laminopathies", "Overview of interferonsmediated signaling pathway", "Overview of nanoparticle effects", "Oxidation by cytochrome p450", "Oxidative damage response", "Oxidative phosphorylation", "Oxidative stress response", "Oxysterols derived from cholesterol", "P38 mapk signaling pathway", "P53 transcriptional gene network", "Pancreatic adenocarcinoma pathway", "Parkinsons disease pathway", "Parkinubiquitin proteasomal system pathway", "Pathogenesis of sarscov2 mediated by nsp9nsp10 complex", "Pathogenic escherichia coli infection", "Pathways affected in adenoid cystic carcinoma", "Pathways of nucleic acid metabolism and innate immune sensing", "Pdgf pathway", "Pdgfrbeta pathway", "Pentose phosphate metabolism", "Pentose phosphate pathway in senescent cells", "Peroxiredoxin 2 induced ovarian failure", "Phase i biotransformations non p450", "Phosphodiesterases in neuronal function", "Phosphoinositides metabolism", "Photodynamic therapyinduced ap1 survival signaling", "Photodynamic therapyinduced hif1 survival signaling", "Photodynamic therapyinduced nfe2l2 nrf2 survival signaling", "Photodynamic therapyinduced nfkb survival signaling", "Photodynamic therapyinduced unfolded protein response", "Physicochemical features and toxicityassociated pathways", "Physiological and pathological hypertrophy of the heart", "Pi3kakt signaling pathway", "Pi3kaktmtor signaling pathway and therapeutic opportunities", "Pi3kaktmtor vitd3 signaling", "Pilocytic astrocytoma", "Pkcgamma calcium signaling pathway in ataxia", "Ppar signaling pathway", "Pparalpha pathway", "Praderwilli and angelman syndrome", "Pregnane x receptor pathway", "Preimplantation embryo", "Primary focal segmental glomerulosclerosis fsgs", "Prion disease pathway", "Progeriaassociated lipodystrophy", "Prolactin signaling pathway", "Prostaglandin and leukotriene metabolism in senescence", "Prostaglandin synthesis and regulation", "Proteasome degradation", "Proteoglycan biosynthesis", "Proximal tubule transport", "Ptf1a related regulatory pathway", "Purine metabolism", "Purine metabolism and related disorders", "Purinergic signaling", "Pyrimidine metabolism", "Pyrimidine metabolism and related diseases", "Rac1pak1p38mmp2 pathway", "Rala downstream regulated genes", "Ranklrank signaling pathway", "Ras and bradykinin pathways in covid19", "Ras signaling", "Regucalcin in proximal tubule epithelial kidney cells", "Regulation of actin cytoskeleton", "Regulation of apoptosis by parathyroid hormonerelated protein", "Regulation of sister chromatid separation at the metaphaseanaphase transition", "Regulation of wnt bcatenin signaling by small molecule compounds", "Regulatory circuits of the stat3 signaling pathway", "Relationship between inflammation cox2 and egfr", "Reninangiotensinaldosterone system raas", "Resistin as a regulator of inflammation", "Retinoblastoma gene in cancer", "Rett syndrome causing genes", "Riboflavin and coq disorders", "Robo4 and vegf signaling pathways crosstalk", "S1p receptor signal transduction", "Sars coronavirus and innate immunity", "Sarscov2 altering angiogenesis via nrp1", "Sarscov2 and covid19 pathway", "Sarscov2 b117 variant antagonises innate immune activation", "Sarscov2 innate immunity evasion and cellspecific immune response", "Sarscov2 replication organelle formation", "Selenium micronutrient network", "Serine metabolism", "Serotonin and anxiety", "Serotonin htr1 group and fos pathway", "Serotonin receptor 2 and elksrfgata4 signaling", "Serotonin receptor 467 and nr3c signaling", "Serotonin transporter activity", "Signal transduction through il1r", "Sleep regulation", "Small cell lung cancer", "Smc1smc3 role in dna damage cornelia de lange syndrome", "Somatroph axis gh and its relationship to dietary restriction and aging", "Sphingolipid metabolism in senescence", "Sphingolipid metabolism integrated pathway", "Sphingolipid metabolism overview", "Sphingolipid pathway", "Spinal cord injury", "Splicing factor nova regulated synaptic proteins", "Srebf and mir33 in cholesterol and lipid homeostasis", "Statin inhibition of cholesterol production", "Steroid biosynthesis", "Sterol regulatory elementbinding proteins srebp signaling", "Sting pathway in kawasakilike disease and covid19", "Striated muscle contraction pathway", "Sudden infant death syndrome sids susceptibility pathways", "Sulfation biotransformation reaction", "Supression of hmgb1 mediated inflammation by thbd", "Synaptic signaling pathways associated with autism spectrum disorder", "Synaptic vesicle pathway", "T cell receptor and costimulatory signaling", "Target of rapamycin tor signaling", "Tca cycle aka krebs or citric acid cycle", "Tca cycle and deficiency of pyruvate dehydrogenase complex pdhc", "Tca cycle in senescence", "Tca cycle nutrient use and invasiveness of ovarian cancer", "Tcell activation sarscov2", "Tcell antigen receptor tcr pathway during staphylococcus aureus infection", "Tcell receptor tcr signaling pathway", "Tgfbeta receptor signaling", "Tgfbeta receptor signaling in skeletal dysplasias", "Tgfbeta signaling in thyroid cells for epithelialmesenchymal transition", "Tgfbeta signaling pathway", "Thermogenesis", "Thiamine metabolic pathways", "Thymic stromal lymphopoietin tslp signaling pathway", "Thyroid hormones production and peripheral downstream signaling effects", "Thyroid stimulating hormone tsh signaling pathway", "Tlr4 signaling and tolerance", "Tnfalpha signaling pathway", "Tnfrelated weak inducer of apoptosis tweak signaling pathway", "Tolllike receptor signaling pathway", "Tolllike receptor signaling related to myd88", "Tp53 network", "Transcription cofactors ski and skil protein partners", "Transcription factor regulation in adipogenesis", "Transcription factors regulate mirnas related to cardiac hypertrophy", "Transcriptional activation by nrf2 in response to phytochemicals", "Translation factors", "Translation inhibitors in chronically activated pdgfra cells", "Transsulfuration and onecarbon metabolism", "Transsulfuration pathway", "Triacylglyceride synthesis", "Tryptophan catabolism leading to nad production", "Tryptophan metabolism", "Tumor suppressor activity of smarcb1", "Type 2 papillary renal cell carcinoma", "Type i collagen synthesis in the context of osteogenesis imperfecta", "Type i interferon induction and signaling during sarscov2 infection", "Type ii diabetes mellitus", "Type ii interferon signaling ifng", "Type iii interferon signaling", "Tyrobp causal network in microglia", "Ultraconserved region 339 modulation of tumor suppressor micrornas in cancer", "Unfolded protein response", "Urea cycle and associated pathways", "Urea cycle and metabolism of amino groups", "Urea cycle and related diseases", "Valproic acid pathway", "Vasopressinregulated water reabsorption", "Vegfavegfr2 signaling pathway", "Vitamin a and carotenoid metabolism", "Vitamin b12 disorders", "Vitamin b12 metabolism", "Vitamin b6dependent and responsive disorders", "Vitamin d in inflammatory diseases", "Vitamin d metabolism", "Vitamin d receptor pathway", "Vitamin dsensitive calcium signaling in depression", "White fat cell differentiation", "Wnt signaling", "Wnt signaling in kidney disease", "Wnt signaling pathway", "Wnt signaling pathway and pluripotency", "Wntbetacatenin signaling pathway in leukemia", "Zinc homeostasis"], "available_proteins": ["AAMP", "AARS", "ABCB1", "ABCD3", "ABCF1", "ABCF2", "ABI1", "ACAA2", "ACACA", "ACACB", "ACAD9", "ACADM", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACLY", "ACO2", "ACOT13", "ACOT7", "ACOT9", "ACOX1", "ACOX3", "ACP1", "ACP6", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN2", "ACTN4", "ACTR2", "ACTR3", "ADAR", "ADH5", "ADI1", "ADK", "ADRM1", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGL", "AGPAT1", "AGPS", "AHCY", "AHCYL1", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AKAP1", "AKAP12", "AKAP13", "AKAP8", "AKR1A1", "AKR1B1", "AKR7A2", "AKT2", "ALDH18A1", "ALDH2", "ALDH3A2", "ALDH5A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALG1", "ALG12", "AMOT", "ANAPC1", "ANAPC10", "ANAPC5", "ANAPC7", "ANLN", "ANP32A", "ANXA1", "ANXA2", "ANXA6", "AP1G1", "AP2A1", "AP2B1", "AP2M1", "AP2S1", "APEX1", "APEX2", "APLP2", "APMAP", "APP", "APRT", "ARCN1", "ARF4", "ARFGAP1", "ARFGAP2", "ARFIP2", "ARHGDIA", "ARHGEF2", "ARID1A", "ARIH2", "ARL2", "ARL3", "ARPC1A", "ARPC2", "ARPC3", "ARPC4", "ARSA", "ASAH1", "ASCC3", "ASNA1", "ASNS", "ATG3", "ATIC", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6", "ATP6AP1", "ATP6AP2", "ATP6V0D1", "ATP6V1A", "ATP6V1C1", "ATP6V1D", "ATP6V1E1", "ATP6V1G1", "ATP6V1H", "ATP7B", "ATPAF1", "ATPIF1", "ATXN10", "ATXN2L", "AURKA", "BAG3", "BAIAP2", "BANF1", "BAZ1A", "BAZ1B", "BCAS3", "BCLAF1", "BCS1L", "BLVRA", "BPTF", "BRAP", "BRD1", "BRIX1", "BSG", "BTAF1", "BTF3", "BUB1B", "BUB3", "BUD23", "C1QBP", "CAB39", "CACYBP", "CAD", "CALD1", "CALM3", "CALR", "CALU", "CAMK1", "CAMK2G", "CAND1", "CAP1", "CAPN1", "CAPN2", "CAPNS1", "CAPZB", "CARM1", "CASK", "CBL", "CBR1", "CBX1", "CBX2", "CBX3", "CBX5", "CCAR2", "CCDC124", "CCDC6", "CCNB1", "CCNB2", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2AP", "CDC20", "CDC23", "CDC25C", "CDC27", "CDC34", "CDC37", "CDC40", "CDC42", "CDC73", "CDK1", "CDK2", "CDK4", "CDK5", "CDK6", "CDX2", "CEBPZ", "CENPF", "CEPT1", "CERS2", "CETN2", "CFL1", "CFL2", "CHAF1A", "CHAMP1", "CHD4", "CHKA", "CHORDC1", "CHRAC1", "CHST14", "CHUK", "CIP2A", "CKB", "CLASP1", "CLASP2", "CLCN7", "CLIC1", "CLIP1", "CLPTM1L", "CLTC", "CLUH", "CMPK1", "CNN2", "CNOT1", "CNOT9", "CNP", "COL4A3BP", "COLEC12", "COLGALT1", "COMT", "COPG1", "COPS2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS7A", "COPS7B", "COPS8", "COQ8A", "COQ9", "CORO1A", "COX2", "COX4I1", "COX5A", "COX6C", "COX7A2", "CPNE1", "CPOX", "CPSF1", "CPSF3", "CPT2", "CRK", "CRKL", "CRTAP", "CS", "CSK", "CSNK1A1", "CSNK2A1", "CSNK2A2", "CSNK2B", "CSTB", "CSTF1", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTH", "CTNNA1", "CTNNB1", "CTNND1", "CTPS1", "CTPS2", "CTSA", "CTSB", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CXADR", "CYB5B", "CYB5R1", "CYB5R3", "CYC1", "CYFIP1", "CYP20A1", "CYP51A1", "DARS", "DBNL", "DCAF1", "DCAF7", "DCTN1", "DCTN2", "DCTN4", "DCTPP1", "DDB1", "DDOST", "DDX1", "DDX17", "DDX20", "DDX21", "DDX3X", "DDX5", "DDX52", "DDX56", "DEK", "DERL1", "DFFA", "DHCR24", "DHCR7", "DHFR", "DHX15", "DHX16", "DHX29", "DHX36", "DHX8", "DHX9", "DIABLO", "DIAPH1", "DIAPH3", "DLAT", "DLD", "DLST", "DNAAF5", "DNAJA1", "DNAJB1", "DNAJC3", "DNAJC7", "DNAJC8", "DNM1L", "DNM2", "DNMT1", "DPM1", "DPP9", "DPYSL2", "DSC1", "DSC3", "DSG2", "DSP", "DSTN", "DTYMK", "DUSP3", "DUSP9", "DUT", "DYNC1H1", "DYNC1LI1", "DYNC1LI2", "DYNC2H1", "DYNLL1", "ECE1", "ECH1", "ECHS1", "ECI1", "ECSIT", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EFTUD2", "EHD1", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF4A1", "EIF4B", "EIF4E", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "ELAVL1", "ELMOD2", "ELOA", "ELOB", "ELOC", "ELP3", "ELP4", "EMD", "ENAH", "ENO1", "ENO2", "EPB41", "EPB41L2", "EPB41L5", "EPHX1", "EPHX2", "EPRS", "EPS15", "EPS15L1", "ERCC2", "ERI1", "ESD", "ETF1", "ETFA", "ETFDH", "EWSR1", "EXO1", "EXOC2", "EXOC3", "EXOC5", "EXOC7", "EXOSC2", "EXOSC7", "EZR", "FAF1", "FAH", "FANCI", "FARSB", "FASN", "FAU", "FDFT1", "FDPS", "FECH", "FEN1", "FGFR1OP", "FH", "FHOD1", "FIS1", "FKBP10", "FKBP1A", "FKBP4", "FKBP5", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FMR1", "FOXRED1", "FSCN1", "FTO", "FUCA1", "FUS", "FXR1", "FXR2", "G3BP1", "G6PD", "GABARAPL2", "GALNT1", "GAPDH", "GART", "GBA", "GCDH", "GCLC", "GCLM", "GDI1", "GFPT1", "GGCT", "GGCX", "GGH", "GIGYF2", "GLA", "GLB1", "GLRX", "GLS", "GLUD1", "GM2A", "GMPPB", "GNA13", "GNAI1", "GNAI2", "GNAI3", "GNPAT", "GNS", "GOT1", "GOT2", "GPAM", "GPD2", "GPI", "GPS1", "GRB2", "GRSF1", "GSK3B", "GSR", "GSS", "GSTK1", "GSTM3", "GSTO1", "GSTZ1", "GTF2I", "GTPBP4", "GUSB", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HADH", "HADHA", "HADHB", "HAT1", "HCFC1", "HDAC2", "HDGF", "HEBP1", "HELLS", "HEXA", "HEXB", "HIBADH", "HIBCH", "HIF1AN", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HLTF", "HMBS", "HMGA1", "HMGB1", "HMGB2", "HMGCS1", "HMOX1", "HNRNPA1", "HNRNPA2B1", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPK", "HNRNPL", "HNRNPM", "HNRNPR", "HNRNPU", "HPRT1", "HSD17B10", "HSD17B12", "HSD17B4", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA14", "HSPA1B", "HSPA4", "HSPA8", "HSPA9", "HSPB1", "HSPD1", "HYOU1", "IARS", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDI1", "IFT27", "IGBP1", "IGF2BP1", "IGF2BP3", "ILF2", "IMPDH1", "IMPDH2", "IPO9", "IQGAP1", "IRF2BPL", "IRS4", "ITGB1", "ITM2C", "ITPA", "IVD", "JUP", "KDM1A", "KDM1B", "KDM3B", "KDSR", "KHDRBS1", "KHSRP", "KIF15", "KIF22", "KIF23", "KIF2C", "KIF4A", "KIF5B", "KIF7", "KLC1", "KMT2A", "KPNA1", "KPNB1", "KTN1", "LARP1", "LARS2", "LBR", "LDHA", "LDHB", "LEMD3", "LGALS3", "LGALS3BP", "LIG1", "LIG3", "LIPA", "LLGL1", "LMAN1", "LMNA", "LMNB1", "LMNB2", "LPCAT3", "LPGAT1", "LRPPRC", "LRRC59", "LRWD1", "LSM2", "LSM7", "LSS", "LTA4H", "MACF1", "MAD2L1", "MANF", "MAP1B", "MAP2K1", "MAP4", "MAPK1", "MAPRE1", "MAPRE2", "MARCKS", "MARS", "MAT2A", "MAT2B", "MAVS", "MBD3", "MCAT", "MCCC1", "MCCC2", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCU", "MDC1", "MDH1", "MDH2", "ME1", "MECP2", "MED1", "MFN2", "MGST2", "MGST3", "MIF", "MKI67", "MOGS", "MORF4L1", "MOV10", "MPC2", "MPI", "MPST", "MRE11", "MRPL19", "MRPL40", "MSH2", "MSH3", "MSH6", "MSN", "MTA1", "MTA2", "MTAP", "MTCH1", "MTDH", "MTHFD1", "MTHFD1L", "MTHFD2", "MTMR2", "MTMR6", "MTOR", "MTR", "MVK", "MYBBP1A", "MYCBP", "MYH10", "MYH9", "MYL6", "MYO1C", "MYO6", "NAA15", "NAA40", "NAA50", "NAE1", "NAGLU", "NAMPT", "NAP1L1", "NAPA", "NARS", "NAT10", "NBN", "NCAPG", "NCBP1", "NCDN", "NCKAP1", "NCL", "NCSTN", "NDUFA10", "NDUFA3", "NDUFA4", "NDUFA5", "NDUFA7", "NDUFA9", "NDUFAF4", "NDUFAF7", "NDUFB10", "NDUFB3", "NDUFB4", "NDUFB5", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS6", "NDUFS7", "NDUFV1", "NDUFV2", "NEFL", "NEFM", "NEK9", "NELFA", "NELFB", "NELFCD", "NELFE", "NIPBL", "NKRF", "NME1", "NME6", "NME7", "NONO", "NOP2", "NPC1", "NPC2", "NRP1", "NSDHL", "NSF", "NTHL1", "NUDC", "NUDT21", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP214", "NUP62", "NUP88", "NUP98", "NXF1", "OAT", "OCLN", "OCRL", "OGDH", "OGT", "OPA1", "OXSR1", "P3H1", "P4HA1", "P4HB", "PABPC1", "PABPN1", "PAF1", "PAFAH1B1", "PAICS", "PAK1", "PAK2", "PAPOLA", "PAPSS1", "PARK7", "PARN", "PARP1", "PBK", "PBRM1", "PC", "PCBP1", "PCBP2", "PCCA", "PCK2", "PCM1", "PCNA", "PDCD4", "PDCD6", "PDCD6IP", "PDE12", "PDE6D", "PDHA1", "PDHB", "PDIA3", "PDIA6", "PDK1", "PDLIM5", "PDLIM7", "PDS5A", "PDS5B", "PEBP1", "PECR", "PELO", "PFAS", "PFDN2", "PFDN4", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGM3", "PGRMC2", "PHB", "PHB2", "PHF5A", "PHF6", "PHF8", "PHGDH", "PHKA1", "PIGT", "PIK3C2A", "PIK3R4", "PIN1", "PIP4K2C", "PISD", "PKM", "PKMYT1", "PKN2", "PLCG1", "PLEC", "PLK1", "PLOD1", "PLOD2", "PMPCA", "PNP", "PNPT1", "PODXL", "POLA1", "POLA2", "POLD1", "POLD2", "POLD3", "POLDIP2", "POLE", "POLE3", "POLE4", "POLR1A", "POLR1B", "POLR1E", "POLR2A", "POLR2B", "POLR2C", "POLR2G", "POLR3A", "POLR3C", "POLRMT", "PON2", "POR", "PPAT", "PPIB", "PPID", "PPIF", "PPM1G", "PPP1CA", "PPP1CB", "PPP1R10", "PPP1R7", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP4C", "PPP4R1", "PPP5C", "PPT2", "PRCC", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PRIM1", "PRIM2", "PRKAG1", "PRKAR1A", "PRKAR2A", "PRKCD", 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sha256:4f10b84612282c28122c4f1c60ae5a1e88d79ae4e0c5b6ebbb9700419086fd85 +size 134883 diff --git a/opencell_localization/basic/plot_3.png b/opencell_localization/basic/plot_3.png new file mode 100644 index 0000000000000000000000000000000000000000..ae160c7cea396fb2dfba41cb41158726435a9f2d --- /dev/null +++ b/opencell_localization/basic/plot_3.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:f0c3e691282a7bd0a7410929ddce0129e3eb60b929ad06cb53a3dff2c94a9653 +size 137433 diff --git a/opencell_localization/consensus.joblib b/opencell_localization/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..79c1c204b9ff03e669c90a2d6579bb66126f9d1a --- /dev/null +++ b/opencell_localization/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:6aa8799ddff2f197cc59414ab24c0871d0738c43a0a658f383a07549503aa4df +size 59651 diff --git a/opencell_localization/df_merge.tsv b/opencell_localization/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..10946b3ca7ad37fe794a4dcb80c66a0107a1c71a --- /dev/null +++ b/opencell_localization/df_merge.tsv @@ -0,0 +1,3 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +er 42 76 2.998039039203727 0.0027172286407113 29.17233009708738 87.61893203883496 1.3358083950399515 0.3757472714196316 13.465054065187209 8.223393744963309 2.0429537263872786 0.4010648005920765 0.0556913553378942 0.4978494903048275 0.3974571713547065 0.0006577660496528 7.336079344802132e-10 +mitochondria 5 10 2.2664277141665705 0.0234252083401569 4.441747572815534 10.567961165048544 1.1937677940164793 0.2159787381789819 2.254231157409949 0.7391563798220593 1.4011905974754153 0.2980089661914649 0.0146989510868729 0.0017062060788896 0.0066572828402184 0.003355333516566 1.6091572544199994e-05 diff --git a/opencell_localization/metrics.json b/opencell_localization/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..21797223791b3fa46df08c6f6781e062aa756384 --- /dev/null +++ b/opencell_localization/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2644, + "annotations_size": 17, + "title": "Average number of proteins per term", + "value": 83.52941176470588 +} \ No newline at end of file diff --git a/opencell_localization/paths.json b/opencell_localization/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..0dde2cbbd85f4405baacc5e3a11d3616560f0efe --- /dev/null +++ b/opencell_localization/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/opencell_localization/fragment/C197/C197_val_log2fc"} \ No newline at end of file diff --git a/opencell_localization/result.tsv b/opencell_localization/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..3fd826ea8d0b4d0308d74460950d1b9217bb3f8b --- /dev/null +++ b/opencell_localization/result.tsv @@ -0,0 +1,5 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +er 0.5482811744260051 2.998039039203727 0.0027172286407113 0.0452022672751719 0.0461928868920926 76 O15270,P27824,P48651,Q16850,P04843,Q9Y5M8,Q9UM00,Q9NQC3,Q969V3,Q9H6H4,O15269,P51572,O75845,Q15041,Q9NPA0,Q14739,Q9UKR5,P48449,Q96GC9,Q969Q5,P46977,Q07065,O95470,Q96N66,P61019,Q15392,Q96A33,Q13190,Q00765,O75915,O96005,Q9Y487,Q9NTJ5,Q9Y3E0,O15173,O00767,Q06136,O00264,Q9NR31,Q8N4V1,O75340,Q9P2W9 42 +mitochondria 0.757839176047884 2.2664277141665705 0.0234252083401569 0.331665833065235 0.1991142708913339 10 Q969Q5,P45880,P21796,O95140,Q9Y277 5 +golgi 0.467435023691576 1.338968880458602 0.1805808039560053 0.966146445652976 0.4388714878398206 53 Q5VW38,Q9Y487,Q8IXU6,O75787,Q8IZA0,Q8TAD4,O15127,Q15904 8 +vesicles 0.4441313160181196 1.1826634015994284 0.2369425743156543 0.9899197154509476 0.4388714878398206 138 Q96L92,O15400,Q8IXU6,P53985,Q13501,Q9H2V7,Q8IZA0,Q5VW38,Q10713,O75787,Q9H6H4,P51798,O15269,O00429,O75845,Q8IY95,P04439,Q9UKR5,P61421,Q93050,P48449,O15127,O95470,Q9UNK0,Q13308,Q06481,P22059,Q15392,P11279,O96005,P02786,Q9Y3E0,O15173,O00264,Q06136,P53990,Q15904 37 diff --git a/opencell_localization/selections.json b/opencell_localization/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..eb5be63f7d9c3feec62848c934bbd808300160b9 --- /dev/null +++ b/opencell_localization/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["big_aggregates", "cell_contact", "centrosome", "chromatin", "cytoplasmic", "cytoskeleton", "er", "focal_adhesions", "golgi", "membrane", "mitochondria", "nuclear_membrane", "nuclear_punctae", "nucleolus_fc_dfc", "nucleolus_gc", "nucleoplasm", "vesicles"], "available_proteins": ["AAMP", "AATF", "ABCE1", "ACLY", "ACTN1", "ACTN4", "ACTR2", "AHCY", "AHSA1", "AKAP12", "AKAP13", "AKAP8L", "AKR1A1", "AKT2", "ALDH16A1", "ALDH9A1", "ANKRD17", "ANXA11", "AP2B1", "AP2S1", "APLP2", "ARF4", "ARFGAP1", "ARFGAP2", "ARFIP1", "ARFIP2", "ARHGAP17", "ARID1A", "ARL1", "ARL2", "ARL3", "ARL6IP1", "ARL6IP5", "ARPC2", "ARPC3", "ATG3", "ATL2", "ATP1A1", "ATP6AP1", "ATP6AP2", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1D", "ATP6V1E1", "ATP6V1G1", "ATP6V1H", "ATXN10", "ATXN2L", "BAG6", "BAIAP2", "BANF1", "BAZ1A", "BAZ1B", "BCAP31", "BLVRA", "BMS1", "BOP1", "BPNT1", "BRD2", "BTF3", "BUB1B", "BUD23", "BYSL", "C1orf123", "C8orf33", "CAD", "CALD1", "CALM3", "CAMK1", "CAMK2G", "CANX", "CAPRIN1", "CAPZB", "CBX1", "CCAR1", "CCDC22", "CCDC47", "CCDC86", "CCNB1", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CDC20", "CDC23", "CDC27", "CDC37", "CDC42", "CDK1", "CDK2", "CDK4", "CDK5", "CEPT1", "CETN2", "CHM", "CHMP2A", "CHMP2B", "CHMP7", "CHUK", "CKAP2", "CKAP4", "CKAP5", "CKB", "CLASP1", "CLASP2", "CLCN7", "CLINT1", "CLIP1", "CLNS1A", "CLPTM1", "CLTC", "CNN2", "COIL", "COL4A3BP", "COMMD2", "COPA", "COPB2", "COPE", "COPG1", "COPG2", "COPZ1", "CORO1C", "CPSF6", "CSE1L", "CSK", "CSNK1A1", "CSNK2A1", "CSNK2A2", "CSNK2B", "CTBP1", "CTBP2", "CTNNB1", "CTNNBL1", "CTPS1", "CTTN", "CYB5R3", "CYP51A1", "DBNL", "DCTN2", "DDB1", "DDOST", "DDX21", "DDX39B", "DDX47", "DDX5", "DDX56", "DDX6", "DHCR24", "DHX37", "DHX9", "DIAPH1", "DKC1", "DNAJA1", "DNAJA2", "DNAJB1", "DNAJC11", "DNAJC2", "DNAJC7", "DNAJC8", "DNAJC9", "DNM1L", "DNM2", "DOCK7", "DPH2", "DRG1", "DYNC1H1", "DYNC1LI1", "DYNC1LI2", "DYNLL1", "EBNA1BP2", "EDC3", "EDC4", "EDF1", "EEF1G", "EFTUD2", "EIF2AK2", "EIF3B", "EIF3E", "EIF3G", "EIF3I", "EIF3K", "EIF3M", "EIF4A1", "EIF4A3", "EIF5", "EMC1", "EMC2", "EMC7", "EMG1", "ENO1", "EPS15", "ERG28", "ESD", "ESYT1", "EWSR1", "EZR", "FASN", "FAU", "FBL", "FDPS", "FKBP5", "FKBP8", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAK", "GAPDH", "GAR1", "GBF1", "GDI1", "GDI2", "GET4", "GNL2", "GNL3", "GOLT1B", "GORASP2", "GPR107", "GRB2", "GSK3B", "GSPT1", "GTPBP4", "H1F0", "HDAC2", "HEATR3", "HLA-A", "HMGA1", "HMGB2", "HMGCS1", "HMGN2", "HNRNPA0", "HNRNPC", "HNRNPD", "HNRNPH1", "HNRNPL", "HNRNPU", "HSP90AA1", "HSP90AB1", "HSPA14", "HSPA1B", "HSPA4", "HSPA4L", "HSPA8", "HSPB1", "HSPBP1", "HSPH1", "IDI1", "IGF2BP1", "IGF2BP3", "ILF3", "INTS14", "INTS9", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IST1", "KDSR", "KIAA0319L", "KIAA0368", "KIF11", "KIF20A", "KIF22", "KIF2A", "KIF2C", "KIF4A", "KIF5B", "KIF7", "KIFBP", "KIFC1", "KLC1", "KPNA1", "KPNA2", "KPNA3", "KPNB1", "LAMP1", "LBR", "LDHA", "LDHB", "LEMD2", "LEMD3", "LIG1", "LMAN1", "LMNA", "LMNB1", "LPCAT1", "LSM14B", "LSS", "LTV1", "MAP2K1", "MAP4", "MAPK1", "MAPRE1", "MBOAT7", "MDH1", "MECP2", "MED21", "MED24", "MED25", "MED4", "MFN2", "MIF", "MKI67", "MMGT1", "MPHOSPH10", "MRTO4", "MSH6", "MSN", "MTMR2", "MTOR", "MVK", "MYBBP1A", "MYH10", "MYH9", "MYL6", "MYO1B", "MYO1C", "MYO6", "NAF1", "NANS", "NAPA", "NAPG", "NCAPH", "NCKAP1", "NCL", "NCLN", "NECAP1", "NECAP2", "NEK9", "NEMF", "NHP2", "NIFK", "NMD3", "NOL10", "NOL11", "NOM1", "NONO", "NOP2", "NOP53", "NOP58", "NPM1", "NSA2", "NSDHL", "NUCKS1", "NUF2", "NUFIP2", "NUMA1", "NUP107", "NUP153", "NUP155", "NUP214", "NUP98", "NVL", "NXF1", "OCRL", "OSBP", "OSBPL8", "OXSR1", "PABPC4", "PACSIN2", "PAK1", "PAK2", "PARP1", "PBK", "PCNA", "PDAP1", "PDCD11", "PDCD6", "PDCD6IP", "PDCL3", "PES1", "PFDN6", "PFN1", "PGK1", "PGRMC1", "PGRMC2", "PHGDH", "PICALM", "PIK3C2A", "PIN4", "PIP4K2C", "PKM", "PKMYT1", "PKN2", "PLK1", "PMPCA", "POLR1A", "POLR1B", "POLR1E", "POLR2A", "POLR2B", "POLR2C", "POLR2G", "POLR3A", "POLR3C", "PPM1G", "PRKCD", "PRKDC", "PRMT9", "PRPF19", "PRPF4B", "PRPF8", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD12", "PSMD13", "PSMD2", "PSMD3", "PSMD4", "PSMD6", "PSMD7", "PSME1", "PSME2", "PSME3", "PSME4", "PSMF1", "PSMG1", "PSMG2", "PSPC1", "PTDSS1", "PTGES3", "PTK7", "RAB10", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB23", "RAB24", "RAB2A", "RAB35", "RAB3GAP2", "RAB5A", "RAB5B", "RAB7A", "RABEPK", "RABGAP1", "RABGGTA", "RAC1", "RACK1", "RAD21", "RAN", "RANBP1", "RANBP2", "RANBP9", "RANGRF", "RBBP4", "RBM10", "RBM12", "RBM12B", "RBM14", "RBM17", "RBM19", "RBM22", "RBM25", "RBM28", "RBM3", "RBM34", "RBM39", "RBM4", "RBM5", "RBM8A", "RBMX", "REEP4", "REEP5", "RELA", "RER1", "RHEB", "RIOK2", "RNASEH2A", "RNF40", "ROCK1", "RPL10A", "RPL11", "RPL13", "RPL19", "RPL27", "RPL35", "RPL4", "RPL5", "RPN1", "RPN2", "RPP30", "RPS11", "RPS14", "RPS16", "RPS18", "RPS6KA1", "RPS6KA3", "RRP1", "RSL1D1", "RTCB", "RTN4", "RUVBL1", "RUVBL2", "S100A10", "SACM1L", "SAE1", "SAR1A", "SARS", "SBDS", "SC5D", "SCAMP2", "SCD", "SCFD1", "SEC16A", "SEC22B", "SEC23A", "SEC24C", "SEC24D", "SEC31A", "SEC61B", "SEPT2", "SEPT7", "SEPT9", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SGPL1", "SH3GL1", "SH3GLB1", "SLC16A1", "SLC1A5", "SLC25A17", "SLC27A4", "SLC30A5", "SLC35F2", "SLC9A3R1", "SLK", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCE1", "SMC1A", "SMN1*", "SNRNP40", "SNRPA", "SNRPC", "SNRPD2", "SNX1", "SNX2", "SNX27", "SNX3", "SNX5", "SNX9", "SPNS1", "SPPL2A", "SPTLC1", "SPTLC2", "SQSTM1", "SRI", "SRP14", "SRP54", "SRP68", "SRP72", "SRP9", "SRPRA", "SRPRB", "SSB", "SSRP1", "STAG2", "STAM", "STIP1", "STT3A", "STT3B", "STX18", "STX5", "STX7", "STX8", "SUPT16H", "SUPT5H", "SYAP1", "TARDBP", "TCOF1", "TFRC", "TJP1", "TMCO1", "TMED10", "TMED2", "TMEM192", "TMPO", "TMPO", "TNPO1", "TNPO3", "TOLLIP", "TOMM20", "TOMM70", "TOP1", "TOP2A", "TOR1AIP1", "TPR", "TPT1", "TRAPPC11", "TRIM28", "TRIM33", "TRMT1L", "TSG101", "TSR1", "TTK", "TUBB4B", "U2AF2", "U2SURP", "UBA1", "UBE2M", "UBTF", "UFC1", "UGDH", "UPF1", "USP10", "USP7", "UTP14A", "UTP4", "UTP6", "UTRN", "VAPA", "VAPB", "VCL", "VCP", "VDAC1", "VDAC2", "VDAC3", "VIM", "VMP1", "VPS16", "VPS18", "VPS29", "VPS35", "VPS4A", "WAPL", "WDR12", "WDR3", "WDR75", "XPO1", "XPO4", "XPO5", "XPOT", "YKT6", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZNF326", "ZYX"], "leading_proteins": ["APLP2", "ARL6IP1", "ARL6IP5", "ATP6AP1", "ATP6AP2", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "BCAP31", "CANX", "CCDC47", "CKAP4", "CLCN7", "CLPTM1", "CYP51A1", "DHCR24", "DNM1L", "EMC7", "ERG28", "GOLT1B", "GPR107", "HLA-A", "IST1", "KDSR", "KIAA0319L", "LAMP1", "LBR", "LSS", "MBOAT7", "MFN2", "MMGT1", "NCLN", "OSBP", "PDCD6", "PGRMC1", "PGRMC2", "PMPCA", "PTDSS1", "PTK7", "RAB24", "RAB2A", "REEP4", "REEP5", "RPN1", "RTN4", "SACM1L", "SAR1A", "SC5D", "SCAMP2", "SCD", "SGPL1", "SLC16A1", "SLC30A5", "SLC35F2", "SNX27", "SPNS1", "SPTLC1", "SPTLC2", "SQSTM1", "SRPRB", "STT3A", "STX18", "STX5", "STX7", "STX8", "TFRC", "TMCO1", "TMEM192", "VDAC1", "VDAC2", "VDAC3", "VMP1"]} \ No newline at end of file diff --git a/panther_protein_class/advanced/idx2term.json b/panther_protein_class/advanced/idx2term.json new file mode 100644 index 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1.2910317153343125 1.5290934655146406 1.1524828353366978 0.2736190413418742 0.0698897647338063 0.134742527043449 0.0334071197556988 0.0352396407582777 0.175898786896668 +primary active transporter 13 20 2.2376183051319383 0.0252459568067502 8.614077669902912 23.45631067961165 1.2392440710771837 0.271771563990288 4.792195908457348 3.1431129799052804 1.4794913205770832 0.3014776193450941 0.5971936063350395 1.0 0.4515227909961177 0.0629955787418294 0.0001660552606358 +oxidase 6 10 2.1834335135526968 0.029003900186636 5.111650485436893 13.890776699029129 1.1786899361665428 0.2351652471103072 2.6295852591466065 1.831549924215542 1.2715889014379809 0.2754701040210626 0.0825057160769616 1.0 1.0 0.007920049564759 0.0202035082798241 +transfer/carrier protein 8 10 2.165504247910944 0.0303490904416339 4.33252427184466 11.024271844660197 0.5751131114698911 0.3717158985009051 2.2946984989028927 1.3525930522279908 1.248808855129494 0.3186564966906889 1.0 1.0 0.2070995190727305 0.0195244436529747 0.0001011247143392 +protease inhibitor 1 9 2.0899698012430967 0.0366205125295091 2.9101941747572817 8.470873786407767 -0.2314103697452487 0.4582528635483486 1.848429656574973 1.4867133927645466 1.0472458882274065 0.2976253017490123 0.0825057160769616 0.1471951297158956 0.0398064357050217 0.1899587232036964 0.2134840601212924 +secondary carrier transporter 10 13 2.0793313362554 0.0375869068134639 6.104368932038835 14.6626213592233 1.264699085385324 0.2718921136589474 3.483843477892234 2.781747184831951 1.2916784116683784 0.322278600042778 0.084014791731071 1.0 0.497470817800254 0.0931141624023252 0.0554394300563215 +oxygenase 5 7 2.0737387119401114 0.0381035838710619 3.138349514563106 6.771844660194175 1.5409868347565758 0.1477866581414416 1.2914149665013366 1.041089559555361 1.2379399582807478 0.2357869798067575 0.2962445638593877 0.1093006244161378 0.2070995190727305 0.1139407547181512 0.0007997701188881 diff --git a/panther_protein_class/metrics.json b/panther_protein_class/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..e927e6a6f08eb030f25a768f6e2bb776852a8a8b --- /dev/null +++ b/panther_protein_class/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2644, + "annotations_size": 154, + "title": "Average number of proteins per term", + "value": 12.019480519480519 +} \ No newline at end of file diff --git a/panther_protein_class/paths.json b/panther_protein_class/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..a6dcc25b432135397ff183d3818921848229c29a --- /dev/null +++ b/panther_protein_class/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/panther_protein_class/fragment/C197/C197_val_log2fc"} \ No newline at end of file diff --git a/panther_protein_class/result.tsv b/panther_protein_class/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..31c4db52f377b618fff82da044d9045fd94d28d6 --- /dev/null +++ b/panther_protein_class/result.tsv @@ -0,0 +1,45 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +serine protease 0.7787751704154682 2.8439588485750673 0.0044556802186821 0.4972729988336459 0.3474267030284688 16 Q9HB40,P10619,Q16740,P42785,Q9H3G5,O14773 6 +membrane trafficking regulatory protein 0.768611639926818 2.6675342475144763 0.0076410101155113 0.6931002826789945 0.3474267030284688 14 P11279,Q8WTV0,P24390,O00560,Q14108 5 +transmembrane signal receptor 0.8670321908289608 2.4389804193872475 0.0147287663037347 0.8982361127356296 0.3474267030284688 8 Q15375,O75787,O15173,Q9UMX5,Q99720,Q96GC9 6 +metalloprotease 0.6565716372707564 2.3185386847512586 0.0204200630638287 0.9582994511367926 0.3474267030284688 26 Q10713,P02786,O95630,Q5JRX3,P55786,Q9UIQ6,Q9BYT8,O75844,P42892,O43847,Q9NZ08 11 +glycosidase 0.9579545454545464 2.3046069900932458 0.0211885941369232 0.9630470340244968 0.3474267030284688 4 Q9BTY2,P04066,P06865 3 +phospholipase 0.856533796086788 2.238707321491635 0.0251749658427364 0.980289041720685 0.3474267030284688 7 Q8NHP8,Q8IV08 2 +primary active transporter 0.647006982258265 2.2376183051319383 0.0252459568067502 0.980508872027935 0.3474267030284688 20 P05026,Q15388,O96008,Q6P4A7,Q9NS69,P05023,P98194,Q15758,Q96NB2,P16615,Q8N4H5,P35670,Q9BUN8 13 +major histocompatibility complex protein 0.9344696969696976 2.211935000685298 0.0269711564275496 0.9851625250083056 0.3474267030284688 4 P55899,P01889,P10321 3 +oxidase 0.7409897594347186 2.1834335135526968 0.029003900186636 0.9892479131193654 0.3474267030284688 10 Q6ZRP7,P14406,O43819,O75845,P36551,Q8NB78 6 +transfer/carrier protein 0.7373716687498695 2.1655042479109436 0.0303490904416339 0.9913149362074524 0.3474267030284688 10 P12235,Q9Y5P4,P12236,O75521,O14828,O15127,P17900,Q9Y5M8 8 +protease inhibitor 0.7539533779869687 2.0899698012430967 0.0366205125295091 0.9968025863509792 0.3474267030284688 9 P05067 1 +secondary carrier transporter 0.6687958962700147 2.0793313362554 0.0375869068134639 0.9972604798242792 0.3474267030284688 13 Q8TB61,O14975,P55011,Q02978,O95202,Q96ES6,Q9Y6M7,Q9UBX3,Q96H78,Q9BXP2 10 +oxygenase 0.8178800967883935 2.0737387119401114 0.0381035838710619 0.9974779178962346 0.3474267030284688 7 P30519,Q14534,Q16850,Q6UW02,Q9BV57 5 +calmodulin-related 0.6332109285668739 1.9320510100039463 0.0533532101639042 0.999784748175518 0.3474267030284688 14 Q02818,P80303,Q14257 3 +SNARE protein 0.8084613630199354 1.8981548243110151 0.0576756898639594 0.9998936197850964 0.3474267030284688 6 Q9UNK0,O15400,Q9P2W9,P51809 4 +cysteine protease 0.585398395086947 1.8630742561201707 0.0624518196439234 0.9999513577484876 0.3474267030284688 23 P07858,Q96FW1,Q92820,Q99538,P53634 5 +esterase 0.8052644143020522 1.8420571031131572 0.0654667976107941 0.9999703797101556 0.3474267030284688 5 Q9NUJ1,Q969T7 2 +voltage-gated ion channel 0.9166982203710768 1.8189717222202368 0.068915744357521 0.9999832388670984 0.3474267030284688 3 P45880,P21796 2 +transporter 0.5175273444110852 1.7342001784369692 0.082882571325364 0.9999983652859342 0.3545532217807239 52 Q99595,O15397,P53985,Q9H2V7,Q9UJZ1,Q9Y619,Q99567,Q92544,O60830,O43615,Q99808,Q92973,Q567V2,Q9H2D1,O43681,O43772,O95373,Q7Z3B4,Q9NR77,Q6N075,Q9HD45,Q8TEM1 22 +mitochondrial carrier protein 0.7331851833595763 1.7015133300099594 0.0888466368891947 0.9999994014667148 0.358606516573028 7 Q9HC21,Q00325,Q6NUK1,Q70HW3,Q9NZJ7 5 +galactosidase 0.9863739591218772 1.6813851798870303 0.0926881222697173 0.9999996877403756 0.358606516573028 2 P06280 1 +G-protein coupled receptor 0.9772899318697954 1.6442218217957374 0.1001303909911701 0.9999999121673356 0.358606516573028 2 Q5VW38 1 +amino acid transporter 0.7704545454545497 1.5424775589564872 0.1229575871147501 0.999999998320532 0.3950773194789548 4 O14925,Q96QD8,O60831 3 +ion channel 0.7171950948642083 1.508331722555828 0.131469648122398 0.9999999996259842 0.4012459582723501 6 Q9C0H2 1 +protein modifying enzyme 0.5220150767589016 1.4536488493583255 0.1460436862309433 0.9999999999723884 0.4325139938377937 22 O00462,P50897,Q9UMR5,O60725,Q92791,O75718 6 +viral or transposable element protein 0.8932626797880379 1.300547095286542 0.1934135259475806 0.9999999999999958 0.5058849413111974 2 Q9NUD5 1 +translation factor 0.6060797083551781 1.1202681508309118 0.2625995099068077 1.0 0.6035869332186327 7 Q06787,P51116 2 +oxidoreductase 0.46797513177557 1.1096932824256531 0.2671312185944796 1.0 0.6049736421110274 37 O96000,O95831,P48163,O14949,O75306,O43676,Q15067,O43169,P16435,Q8N4Q0,Q9Y320 11 +glycosyltransferase 0.4655770933920329 1.0983602132263326 0.2720472285579207 1.0 0.6071778724336202 18 Q10472,Q10471,Q16739,Q9BV10,Q8NBN7,Q9BT22,Q8N6G5,P46977 8 +ATP synthase 0.434767707318493 0.8741845453649792 0.382017761006264 1.0 0.7314209086812332 21 Q93050,Q9Y487,O75964 3 +small GTPase 0.5074669031737034 0.855019133320599 0.3925405555338814 1.0 0.7336735098013962 9 P11233 1 +transferase 0.4200777332632698 0.7579632958018646 0.4484729561125156 1.0 0.7673870582369712 24 O14880,P43490,Q8NCH0,Q99735,P25325,P37268,Q9Y5P6,O43505 8 +histone modifying enzyme 0.4821692736922994 0.7261118943658176 0.4677701779093994 1.0 0.7851857873664003 9 Q9H7B4,Q9H9T3 2 +membrane traffic protein 0.3855126482556023 0.6031139036037853 0.5464329177053384 1.0 0.8500067608749708 52 Q99523,P11717,Q9H223,Q9H6H4,Q9H4M9,A6NIH7,O00429,Q9NX40,Q8N2H4,P20645,P43307 11 +acyltransferase 0.3837946638423771 0.4969982655787333 0.6191902744142903 1.0 0.8892997753572631 16 Q9BWD1,P23786,Q8NCC3 3 +cadherin 0.5231767518201947 0.3400572383522252 0.7338134236140064 1.0 0.9113489293270725 3 Q14574 1 +kinase activator 0.5130650021127655 0.3130724027486972 0.7542256553352376 1.0 0.9144463179186088 3 O95067 1 +protease 0.3554504735562965 0.2669783368922673 0.7894858405457794 1.0 0.9144463179186088 37 O75976,P20618,P49720,P49721,P28070 5 +kinase 0.3436674463773212 0.2589328445715471 0.795687055851257 1.0 0.9144463179186088 16 P35790,Q9Y5B8,Q9HA64 3 +acetyltransferase 0.3997818085423749 0.2261570911081733 0.8210792423477498 1.0 0.9297514950114224 7 Q96N66 1 +methyltransferase 0.3401242835579876 0.1595106143932202 0.8732665963093011 1.0 0.9745148973306694 11 P21964,Q9BV86 2 +kinase modulator 0.3736912738418178 0.1327522746612062 0.8943892994861329 1.0 0.9838282294347462 5 P10644 1 +nucleic acid metabolism protein 0.3462121212121286 0.0737359605084724 0.9412204843122164 1.0 1.0 4 P49750,Q9NYF8,Q9Y2W1 3 +G-protein modulator 0.3042819249715833 0.0049018149362251 0.996088933204861 1.0 1.0 5 P52565,P31150,Q9H2M9,P50395 4 diff --git a/panther_protein_class/selections.json b/panther_protein_class/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..c7f1cf60a8b986720ae953da037c197ee59ba9a9 --- /dev/null +++ b/panther_protein_class/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["ATP synthase", "ATP-binding cassette (ABC) transporter", "C2H2 zinc finger transcription factor", "DNA glycosylase", "DNA helicase", "DNA ligase", "DNA metabolism protein", "DNA methyltransferase", "DNA polymerase processivity factor", "DNA topoisomerase", "DNA-binding transcription factor", "DNA-directed DNA polymerase", "DNA-directed RNA polymerase", "G-protein", "G-protein coupled receptor", "G-protein modulator", "GTPase-activating protein", "Hsp90 family chaperone", "P53-like transcription factor", "RNA helicase", "RNA metabolism protein", "RNA methyltransferase", "RNA processing factor", "RNA splicing factor", "Rel homology transcription factor", "SNARE protein", "acetyltransferase", "actin and actin related protein", "actin binding motor protein", "actin or actin-binding cytoskeletal protein", "acyltransferase", "aldolase", "amino acid kinase", "amino acid transporter", "aminoacyl-tRNA synthetase", "apolipoprotein", "aspartic protease", "basic leucine zipper transcription factor", "cadherin", "calcium-binding protein", "calmodulin-related", "carbohydrate kinase", "cell adhesion molecule", "centromere DNA-binding protein", "chaperone", "chaperonin", "chromatin/chromatin-binding, or -regulatory protein", "cyclase", "cysteine protease", "cytokine", "cytoskeletal protein", "damaged DNA-binding protein", "deaminase", "decarboxylase", "defense/immunity protein", "dehydratase", "dehydrogenase", "endodeoxyribonuclease", "endoribonuclease", "epimerase/racemase", "esterase", "exodeoxyribonuclease", "exoribonuclease", "extracellular matrix glycoprotein", "extracellular matrix protein", "extracellular matrix structural protein", "galactosidase", "general transcription factor", "glucosidase", "glycosidase", "glycosyltransferase", "growth factor", "guanyl-nucleotide exchange factor", "heterotrimeric G-protein", "histone", "histone modifying enzyme", "homeodomain transcription factor", "hydratase", "hydrolase", "integrin", "intercellular signal molecule", "intermediate filament binding protein", "ion channel", "isomerase", "kinase", "kinase activator", "kinase inhibitor", "kinase modulator", "ligase", "lipase", "lyase", "mRNA capping factor", "mRNA polyadenylation factor", "major histocompatibility complex protein", "membrane traffic protein", "membrane trafficking regulatory protein", "metalloprotease", "methyltransferase", "microtubule binding motor protein", "microtubule or microtubule-binding cytoskeletal protein", "mitochondrial carrier protein", "mutase", "non-motor actin binding protein", "non-motor microtubule binding protein", "non-receptor serine/threonine protein kinase", "nucleic acid metabolism protein", "nucleotide kinase", "nucleotide phosphatase", "nucleotidyltransferase", "oxidase", "oxidoreductase", "oxygenase", "peptide hormone", "peroxidase", "phosphatase", "phosphatase activator", "phosphatase modulator", "phosphodiesterase", "phospholipase", "primary active transporter", "primase", "protease", "protease inhibitor", "protein modifying enzyme", "protein phosphatase", "protein-binding activity modulator", "pyrophosphatase", "reductase", "ribosomal protein", "scaffold/adaptor protein", "secondary carrier transporter", "serine protease", "small GTPase", "structural protein", "tight junction", "transaminase", "transcription cofactor", "transfer/carrier protein", "transferase", "transketolase", "translation elongation factor", "translation factor", "translation initiation factor", "translation release factor", "translational protein", "transmembrane signal receptor", "transporter", "tubulin", "tyrosine protein kinase receptor", "ubiquitin-protein ligase", "vesicle coat protein", "viral or transposable element protein", "voltage-gated ion channel", "zinc finger transcription factor"], "available_proteins": ["AARS", "AARS2", "AASDHPPT", "AATF", "ABCB1", "ABCB7", "ABCD3", "ABCF1", "ABCF2", "ABCF3", "ABHD10", "ABHD12", "ABHD6", "ABI1", "ACAA2", "ACAD9", "ACADM", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACLY", "ACO2", "ACOT13", "ACOT7", "ACOT9", "ACOX1", "ACOX3", "ACP1", "ACP2", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTR1A", "ACTR2", "ACTR3", "ADAR", "ADD1", "ADD3", "ADH5", "ADI1", "ADPGK", "ADPRHL2", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGK", "AGPAT1", "AHCY", "AHCYL1", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AK3", "AKAP1", "AKAP12", "AKAP8", "AKAP8L", "AKR1A1", "AKR1B1", "AKR7A2", "AKT2", "ALDH16A1", "ALDH18A1", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALG1", "ALG12", "ALKBH5", "ANAPC1", "ANAPC10", "ANAPC7", "ANKRD17", "ANLN", "ANP32A", "ANP32B", "ANXA1", "ANXA11", "ANXA2", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP1M1", "AP1S2", "AP2A1", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "APEH", "APLP2", "APOL2", "APP", "APRT", "ARCN1", "ARF4", "ARFGAP1", "ARFGAP2", "ARFIP1", "ARFIP2", "ARHGDIA", "ARID3B", "ARIH1", "ARIH2", "ARL1", "ARL6IP5", "ARPC1A", "ARPC3", "ARPC4", "ARSA", "ASAH1", "ASCC3", "ASH2L", "ASNA1", "ASNS", "ASPH", "ASRGL1", "ATG3", "ATL2", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2C1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6", "ATP6AP1", "ATP6AP2", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1D", "ATP6V1G1", "ATP6V1H", "ATP7B", "ATPAF1", "ATPIF1", "ATXN2L", "AUP1", "AURKA", "B4GAT1", "BAG6", "BAIAP2", "BCAP31", "BCLAF1", "BLMH", "BLVRA", "BOP1", "BPNT1", "BRD1", "BRIX1", "BSG", "BTF3", "BUB1B", "BUB3", "BUD23", "BUD31", "BZW1", "BZW2", "CACYBP", "CAD", "CALD1", "CALM3", "CALR", "CALU", "CAMK1", "CAMK2G", "CAND1", "CAND2", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPRIN1", "CAPZA1", "CAPZA2", "CAPZB", "CARM1", "CARS", "CASK", "CAST", "CBL", "CBR1", "CCAR1", "CCAR2", "CCNB1", "CCNB2", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CDC20", "CDC23", "CDC25C", "CDC27", "CDC37", "CDC40", "CDC42", "CDK1", "CDK2", "CDK4", "CDK5", "CDK6", "CDKN2AIP", "CDX2", "CEBPZ", "CEPT1", "CETN2", "CFL1", "CFL2", "CHAF1A", "CHAF1B", "CHERP", "CHKA", "CHM", "CHMP2A", "CHMP2B", "CHMP7", "CHORDC1", "CHRAC1", "CHST14", "CHUK", "CKAP2", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLASP2", "CLCC1", "CLCN3", "CLCN7", "CLGN", "CLIC1", "CLIC4", "CLIP1", "CLNS1A", "CLPB", "CLPP", "CLPX", "CLTC", "CLUH", "CMAS", "CMPK1", "CNDP2", "CNN2", "CNN3", "CNOT1", "CNOT2", "CNOT3", "CNOT4", "CNOT7", "CNP", "COIL", "COL4A3BP", "COLEC12", "COLGALT1", "COMT", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS8", "COPZ1", "COQ3", "CORO1A", "CORO1C", "CORO7", "COTL1", "COX2", "COX4I1", "COX5A", "COX7A2", "CPD", "CPOX", "CPSF1", "CPSF3", "CPSF6", "CPSF7", "CPT2", "CPVL", "CRK", "CRKL", "CRNKL1", "CRTAP", "CRYZ", "CS", "CSE1L", "CSGALNACT2", "CSNK1A1", "CSNK2B", "CSTB", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTH", "CTNNA1", "CTNND1", "CTPS1", "CTPS2", "CTSA", "CTSB", "CTSC", "CTTN", "CTU2", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CYB5B", "CYB5D2", "CYB5R1", "CYB5R3", "CYFIP1", "CYP20A1", "CYP51A1", "DAP3", "DARS", "DARS2", "DBN1", "DBNL", "DCAKD", "DCPS", "DCTN1", "DCTN2", "DCTN3", "DCTN4", "DCTPP1", "DCXR", "DDB1", "DDI2", "DDOST", "DDT", "DEK", "DENR", "DERL1", "DHCR24", "DHCR7", "DHFR", "DHRS1", "DHRS7", "DHX15", "DHX16", "DHX29", "DHX30", "DHX36", "DHX37", "DHX8", "DHX9", "DIDO1", "DIEXF", "DIMT1", "DIS3", "DKC1", "DLAT", "DLD", "DLST", "DNAAF5", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC2", "DNAJC7", "DNAJC8", "DNAJC9", "DNASE2", "DNM1L", "DNM2", "DNMT1", "DNPH1", "DOCK7", "DOHH", "DPH5", "DPM1", "DPP3", "DPP9", "DPYSL2", "DPYSL5", "DSC1", "DSC3", "DSG2", "DSP", "DST", "DSTN", "DTYMK", "DUSP12", "DUSP9", "DUT", "DYNC1H1", "DYNC1LI1", "DYNC1LI2", "DYNC2H1", "DYNLL1", "ECE1", "ECH1", "ECHS1", "ECI1", "ECI2", "ECSIT", "EDC4", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF2", "EFHD1", "EFL1", "EFTUD2", "EHD1", "EHD4", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2D", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF4B", "EIF4E", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "ELAC2", "ELAVL1", "ELMO2", "ELMOD2", "ELOB", "ELOC", "ELP1", "ELP3", "EMC2", "EMG1", "ENAH", "ENO1", "ENO2", "EPHA7", "EPHX1", "EPHX2", "EPPK1", "EPRS", "EPS15", "EPS15L1", "ERAL1", "ERAP1", "ERCC2", "ERH", "ERI1", "ERMP1", "ERO1A", "ERP29", "ESD", "ETF1", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXO1", "EXOC3", "EXOC5", "EXOC7", "EXOSC2", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "EZR", "FAHD1", "FAM98B", "FARSA", "FARSB", "FBL", "FCGRT", "FDFT1", "FDPS", "FECH", "FEN1", "FH", "FKBP14", "FKBP1A", "FKBP3", "FKBP4", "FKBP5", "FKBP7", "FKBP8", "FLAD1", "FLII", "FMR1", "FN3KRP", "FNTB", "FOXRED1", "FRG1", "FSCN1", "FTO", "FTSJ3", "FUBP1", "FUBP3", "FUCA1", "FUCA2", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GAK", "GALK1", "GALM", "GALNT1", "GALNT2", "GALNT7", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GATAD2A", "GBF1", "GCAT", "GCDH", "GCFC2", "GCLC", "GCLM", "GCN1", "GDI1", "GDI2", "GDPD1", "GFPT1", "GGH", "GLA", "GLB1", "GLDC", "GLMN", "GLO1", "GLRX", "GLRX3", "GLRX5", "GLS", "GLUD1", "GLYR1", "GM2A", "GMFB", "GMPPB", "GMPS", "GNA13", "GNAI1", "GNAI2", "GNAI3", "GNPAT", "GNPDA1", "GNS", "GOLGA3", "GOLT1B", "GOPC", "GOT1", "GOT2", "GPAM", "GPATCH4", "GPD2", "GPI", "GPKOW", "GPR107", "GPR108", "GRHPR", "GRPEL1", "GRSF1", "GSK3B", "GSPT1", "GSR", "GSS", "GSTK1", "GSTM3", "GSTZ1", "GTF2I", "GTF3C1", "GTF3C3", "GTF3C4", "GTPBP1", "GTPBP3", "GUF1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACL1", "HADHB", "HAT1", "HBS1L", "HCCS", "HDGF", "HDGFL2", "HDHD2", "HDHD5", "HDLBP", "HEATR1", "HECTD1", "HECTD3", "HEXA", "HEXB", "HIBADH", "HIBCH", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HM13", "HMBS", "HMGA1", "HMGN2", "HMOX1", "HMOX2", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPM", "HNRNPR", "HP1BP3", "HPF1", "HPRT1", "HSD17B10", "HSDL1", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPE1", "HTATIP2", "HUWE1", "IARS", "IARS2", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDI1", "IGBP1", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IK", "ILF2", "ILF3", "ILKAP", "ILVBL", "IMP4", "IMPDH1", "IMPDH2", "INTS11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IRF2BPL", "ISCU", "ISOC1", "ISYNA1", "ITGB1", "ITPA", "IVD", "KARS", "KCTD12", "KDELR1", "KDM1A", "KDM1B", "KDM3B", "KDSR", "KHDRBS1", "KHSRP", "KIAA0368", "KIF11", "KIF15", "KIF18B", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF4A", "KIF5B", "KIF7", "KIFC1", "KLC1", "KMT2A", "KPNA1", "KPNA2", "KPNA3", "KPNB1", "KRR1", "LAMP1", "LAP3", "LARP1", "LARP4", "LARP4B", "LARS", "LARS2", "LBR", "LCLAT1", "LDAH", "LDHA", "LDHB", "LETM1", "LGALS3", "LGMN", "LIG1", "LIG3", "LIMA1", "LIPA", "LLGL1", "LMAN1", "LMAN2", "LNPEP", "LONP1", "LPCAT1", "LPCAT3", "LPGAT1", "LRRC40", "LRRC47", "LRRC59", "LRWD1", "LSM14B", "LSM2", "LSM6", "LSM7", "LSS", "LTN1", "LYAR", "LYPLA1", "M6PR", "MACF1", "MAGED2", "MANBA", "MAP1B", "MAP1S", "MAP2K1", "MAPK1", "MAPRE1", "MAPRE2", "MARS", "MAT2A", "MAT2B", "MBOAT7", "MCCC1", "MCCC2", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MDH1", "MDH2", "ME1", "MECP2", "MED1", "MED21", "MED23", "MED24", "MED25", "MED4", "MFSD3", "MFSD5", "MGEA5", "MGST2", "MGST3", "MIA2", "MICU1", "MID1", "MIF", "MINPP1", "MIPEP", "MKRN2", "MMS19", "MOGS", "MORF4L1", "MORF4L2", "MPHOSPH10", "MPI", "MPP6", "MPRIP", "MPST", "MPV17L2", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL14", "MRPL15", "MRPL19", "MRPL21", "MRPL28", "MRPL3", "MRPL37", "MRPL38", "MRPL39", "MRPL40", "MRPL44", "MRPL45", "MRPL46", "MRPL47", "MRPL48", "MRPL49", "MRPL50", "MRPL53", "MRPL9", "MRPS11", "MRPS2", "MRPS22", "MRPS23", "MRPS25", "MRPS27", "MRPS28", "MRPS30", "MRPS31", "MRPS33", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRPS9", "MSH2", "MSH3", "MSH6", "MSN", "MTA1", "MTA2", "MTAP", "MTCH1", "MTCH2", "MTMR2", "MTMR6", "MTOR", "MTPAP", "MVK", "MYBBP1A", "MYCBP", "MYDGF", "MYG1", "MYL6", "MYO1B", "MYO1C", "MYO1D", "MYO6", "NAA15", "NAA25", "NAA50", "NAE1", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NAPG", "NARS", "NASP", "NAT10", "NAXE", "NBN", "NCAPD2", "NCBP1", "NCDN", "NCKIPSD", "NCOA5", "NDRG3", "NDUFA10", "NDUFA3", "NDUFA4", "NDUFA5", "NDUFA7", "NDUFA9", "NDUFB10", "NDUFB3", "NDUFB4", "NDUFB5", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS6", "NDUFS7", "NDUFV1", "NDUFV2", "NECAP1", "NECAP2", "NENF", "NHP2", "NIPBL", "NKRF", "NLN", "NME1", "NME6", "NME7", "NMT1", "NNT", "NOC4L", "NOL6", "NOL9", "NOM1", "NONO", "NOP14", "NOP56", "NOP58", "NPEPPS", "NPM1", "NRDC", "NSDHL", "NSF", "NSFL1C", "NSUN2", "NT5C2", "NT5C3B", "NT5DC1", "NT5DC2", "NTHL1", "NTMT1", "NTPCR", "NUCB1", "NUCB2", "NUDC", "NUDCD2", "NUDT1", "NUDT12", "NUDT21", "NUDT5", "NUF2", "NUMA1", "NUP107", "NUP153", "NUP155", "NUP160", "NUP210", "NUP214", "NUP37", "NUP50", "NUP54", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NXF1", "NXN", "OAT", "OCIAD1", "OCLN", "OCRL", "OGDH", "OGT", "OLA1", "OPA1", "OSGEP", "OTUB1", "OXA1L", "P3H1", "P3H4", "P4HA1", "P4HB", "PA2G4", "PABPN1", "PACSIN2", "PAFAH1B2", "PAFAH1B3", "PAK1", "PAK1IP1", "PAK2", "PANK4", "PAPOLA", "PARN", "PARP1", "PATL1", "PBK", "PBRM1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCK2", "PCMT1", "PCNA", "PCYOX1", "PDCD11", "PDCD4", "PDCD5", "PDCD6", "PDCD6IP", "PDCL3", "PDE12", "PDE6D", "PDHA1", "PDHB", "PDIA3", "PDIA4", "PDIA6", "PDK1", "PDK3", "PDLIM1", "PDLIM3", "PDLIM5", "PDLIM7", "PDPR", "PDS5A", "PDS5B", "PDXK", "PEBP1", "PECR", "PELO", "PEPD", "PES1", "PEX14", "PEX19", "PFDN2", "PFDN5", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGGT1B", "PGK1", "PGLS", "PGM1", "PGM2", "PGM3", "PGP", "PGRMC1", "PGRMC2", "PHF14", "PHF6", "PHGDH", "PHKA1", "PICALM", "PIK3C2A", "PIK3R4", "PIN1", "PIP4K2C", "PIR", "PISD", "PITHD1", "PITPNB", "PITRM1", "PKM", "PKMYT1", "PKN2", "PLA2G15", "PLAA", "PLBD2", "PLCG1", "PLD3", "PLD6", "PLEC", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLS3", "PM20D2", "PMPCA", "PMPCB", "PNP", "PNPT1", "PODXL", "POGZ", "POLA1", "POLA2", "POLD1", "POLD2", "POLD3", "POLDIP3", "POLE", "POLE3", "POLE4", "POLR1A", "POLR1B", "POLR1E", "POLR2A", "POLR2B", "POLR2C", "POLR2G", "POLR3A", "POLR3C", "POLRMT", "POR", "PPA1", "PPA2", "PPAN", "PPAT", "PPIB", "PPID", "PPIF", "PPIG", "PPIH", "PPIL4", "PPM1G", "PPME1", "PPP1CA", "PPP1CB", "PPP1R10", "PPP1R7", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP4C", "PPP4R1", "PPP5C", "PPP6C", "PPT1", "PPT2", "PQBP1", "PRAF2", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PREP", "PREPL", "PRIM1", "PRIM2", "PRKAG1", "PRKAR1A", "PRKAR2A", "PRKCD", "PRKCSH", "PRKDC", "PRMT1", "PRMT3", "PRMT5", "PRMT9", "PRPF19", "PRPF3", "PRPF31", "PRPF39", "PRPF4", "PRPF4B", "PRPF6", "PRPF8", "PRPS1", "PRPSAP1", "PRPSAP2", "PRRC2A", "PRRC2C", "PSAP", "PSAT1", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD7", "PSMD8", "PSMF1", "PSMG1", "PSMG2", "PSPC1", "PTCD1", "PTDSS1", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK7", "PTPA", "PTPN1", "PTPN11", "PUF60", "PURA", "PUS1", "PWP1", "PXMP2", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QDPR", "QKI", "QSOX2", "RAB3GAP2", "RABGAP1", "RABGGTA", "RABL6", "RAC1", "RACGAP1", "RAD23A", "RAD23B", "RAE1", "RALA", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP9", "RANGAP1", "RAP2B", "RAPGEF2", "RARS", "RARS2", "RAVER1", "RB1", "RBBP6", "RBM12", "RBM12B", "RBM14", "RBM17", "RBM19", "RBM22", "RBM26", "RBM27", "RBM34", "RBM4", "RCL1", "RCN1", "RCN2", "RDH11", "RDH13", "RDX", "RECQL", "REEP4", "REEP5", "RELA", "REPS1", "REXO4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RHEB", "RHOT1", "RHOT2", "RIDA", "RIF1", "RIOK2", "RNASEH2A", "RNF2", "ROCK1", "ROCK2", "RPA1", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPN1", "RPN2", "RPP30", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RRBP1", "RRM1", "RRM2", "RRS1", "RSF1", "RSL1D1", "RSL24D1", "RSU1", "S100A10", "S100A11", "S100A13", "SACM1L", "SAE1", "SAMHD1", "SAP130", "SAP18", "SAP30BP", "SARS", "SARS2", "SART1", "SART3", "SBDS", "SC5D", "SCAMP2", "SCAMP3", "SCARB1", "SCARB2", "SCFD1", "SCML2", "SCO1", "SCO2", "SCP2", "SCPEP1", "SCRIB", "SDCBP", "SDE2", "SDF4", "SDHA", "SDHB", "SDR39U1", "SEC11A", "SEC23A", "SEC23IP", "SEC24A", "SEC24B", "SEC24C", "SEC24D", "SEC31A", "SEC61A1", "SEC61B", "SEC61G", "SEC63", "SEH1L", "SENP3", "SEPHS1", "SEPT2", "SEPT7", "SEPT9", "SERBP1", "SERPINB6", "SERPINH1", "SET", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFSWAP", "SFXN1", "SFXN2", "SFXN4", "SHMT1", "SHMT2", "SHOC2", "SIGMAR1", "SIN3A", "SKIV2L", "SKIV2L2", "SKP1", "SLC12A2", "SLC12A9", "SLC16A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A19", "SLC25A20", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A4", "SLC25A42", "SLC25A44", "SLC25A5", "SLC25A6", "SLC27A2", "SLC27A4", "SLC29A1", "SLC35B2", "SLC38A2", "SLC4A1AP", "SLC4A7", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCE1", "SMC6", "SMN1*", "SMNDC1", "SMPD4", "SMYD3", "SNRNP200", "SNRNP70", "SNRPA", "SNRPA1", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNW1", "SNX1", "SNX2", "SNX27", "SNX5", "SNX6", "SNX9", "SOD2", "SON", "SORT1", "SPAG9", "SPCS2", "SPEN", "SPNS1", "SPPL2A", "SPR", "SPTLC1", "SPTLC2", "SQLE", "SREK1", "SRI", "SRM", "SRP14", "SRP54", "SRP68", "SRP9", "SRPK1", "SRPRA", "SRPRB", "SRRM1", "SRSF1", "SRSF10", "SRSF11", "SRSF2", "SRSF3", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSR1", "STAG2", "STAM", "STAMBP", "STAT1", "STAT3", "STOM", "STOML2", "STRAP", "STRBP", "STT3A", "STT3B", "STUB1", "STX18", "STX4", "STX5", "STX7", "STX8", "STXBP3", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGP2", "SUN1", "SUPT16H", "SUPT6H", "SUPV3L1", "SURF4", "SURF6", "SUZ12", "SYNCRIP", "SYNGR2", "SYS1", "TAF15", "TAF6L", "TAGLN2", "TALDO1", "TARS", "TARS2", "TBC1D13", "TBC1D15", "TBC1D4", "TBC1D9B", "TBCA", "TBCB", "TBCD", "TBCE", "TBL3", "TCEA1", "TCERG1", "TCOF1", "TCP1", "TDRKH", "TECR", "TERF2IP", "TFCP2", "TFG", "TFRC", "THADA", "THOC1", "THOC2", "THOC3", "THOP1", "THRAP3", "THUMPD3", "TIAL1", "TIGAR", "TIMM17A", "TIMM17B", "TIMM23", "TIMM44", "TJP1", "TK1", "TKT", "TM9SF3", "TM9SF4", "TMED10", "TMED2", "TMED5", "TMED7", "TMED9", "TMEM259", "TMOD3", "TMPO", "TMX2", "TNPO1", "TNPO3", "TOE1", "TOMM20", "TOMM22", "TOMM40", "TOMM5", "TOMM70", "TOP1", "TOP2A", "TOP2B", "TP53", "TP53BP2", "TPI1", "TPM1", "TPM3", "TPM4", "TPP1", "TPP2", "TPR", "TPT1", "TPX2", "TRAF2", "TRAP1", "TRAPPC4", "TRIM21", "TRIM33", "TRIO", "TRIP12", "TRIP13", "TRMT10C", "TRMT1L", "TRMT6", "TROVE2", "TRUB1", "TSFM", "TSG101", "TTK", "TTYH3", "TUBB", "TUBB2A", "TUBB2B", "TUBB4A", "TUBB4B", "TUBB6", "TUBGCP2", "TUBGCP3", "TUFM", "TWF1", "TWF2", "TXLNA", "TXLNG", "TXNDC12", "TXNDC17", "TXNDC5", "TXNDC9", "TXNL1", "TXNRD1", "TYMS", "U2SURP", "UBA1", "UBA2", "UBA3", "UBA6", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2Q1", "UBE2S", "UBE3C", "UBE4A", "UBR2", "UBR4", "UBR5", "UBR7", "UBTF", "UCHL5", "UCK2", "UFL1", "UGCG", "UGDH", "UGGT1", "UHRF1", "UMPS", "UNC119B", "UQCC2", "UQCR10", "UQCRC1", "UQCRC2", "UQCRQ", "UROD", "USMG5", "USO1", "USP10", "USP11", "USP14", "USP24", "USP28", "USP34", "USP39", "USP47", "USP48", "USP5", "USP7", "USP8", "USP9X", "UTP14A", "UTP15", "UTP6", "VAMP7", "VAPA", "VAPB", "VARS1", "VBP1", 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score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Receptor 9 21 2.863728289626413 0.0041868698797613 8.25242718446602 27.344660194174757 1.739519175745715 0.1905542238199536 2.855648283399814 4.245230977176689 1.1861053756197322 0.2707159726336181 0.0008658549306675 0.0919108957066336 0.0189133156354044 0.0002404466495136 0.0134563760470189 +SLC superfamily of solute carriers 32 40 2.691928862747599 0.0071040096319032 18.888349514563107 44.33009708737864 2.1618907004737498 0.1690913715307362 9.633686860107934 5.825351940723624 1.7350998035598977 0.2760301582542676 0.0167448447919799 1.0 0.5250511846313772 0.0047362689607466 2.2028477393042965e-06 +Protease inhibitor 2 10 2.588220814955978 0.0096473115276625 3.021844660194174 10.191747572815531 0.0156913070142034 0.5225114188512615 1.89070503497177 2.0561604935207436 0.9786766316122176 0.2972879918724294 0.0376094771987919 0.0248381956323572 0.0128487417044244 0.1257511849434855 0.2330449655141378 +Signaling 5 18 2.549232954624962 0.0107960158003379 5.66747572815534 18.009708737864077 1.330299096012152 0.2668377480945127 2.507969905227609 1.6994867622232877 1.0107551340834326 0.2926688105318188 0.3662640307214173 0.3467229085425889 0.5741114914523541 0.1646032801604304 0.2536407090798045 +Oxidase 5 16 2.454484976200507 0.01410865598669 6.703883495145631 19.237864077669904 1.0247065178117305 0.263154064152295 3.1321515397534676 1.9967748999180144 1.3264616190823058 0.2799417791483025 0.0001029866286304 0.1471951297158956 0.2732850813359189 0.0001216265378748 0.0008544422426654 +SLC25 family of mitochondrial transporters 15 20 2.276710837190061 0.0228034989421126 9.148058252427184 20.71359223300971 2.0411027534642088 0.1411881998864352 5.368907349966936 1.8276489510009888 1.309103123363054 0.2428184236965967 0.0162384338019031 1.0 0.048990890514732 0.0018532910789756 6.940644098281289e-06 +Reductase 5 15 2.2759308030998624 0.0228501515178269 4.563106796116505 16.313106796116504 1.2016212969729014 0.3130807121312539 1.9089462498224232 1.180966799206311 0.8349037556988175 0.2876306629725971 0.008306523376722 1.0 0.031373049189738 0.0049571663496986 0.0022975467393054 +Lipase 2 5 2.126379447374374 0.0334716776648373 1.3980582524271843 5.075242718446602 -0.1568413865531176 0.2870211072037147 0.9252636026942443 1.467005631758797 1.4600847921937092 0.2541679924186693 0.316575497809577 1.0 0.2223047329091382 0.0242110622206542 0.1292339698967795 +Mitochondrial amino acid transporter subfamily 2 5 2.1009962306655923 0.0356412971325654 1.75 5.106796116504855 1.5314439851709 0.1644824524943633 1.357512359363716 0.7195281808878056 0.8276270779181836 0.2049815877367878 0.0055333948599419 1.0 0.0743799864466655 0.0007187465088185 0.0052730305790767 +Mitochondrial nucleotide transporter subfamily 7 9 1.971382188388229 0.0486801768190481 4.216019417475728 9.065533980582524 1.5870110662923598 0.1668197633609344 2.720728714423222 1.1029864386277723 1.1616247375257451 0.2431804664231326 0.1970637688620001 1.0 0.1349531130589082 0.0498779046475234 0.0048470794580564 diff --git a/pharos_dto/metrics.json b/pharos_dto/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..64a0d03b72d37f7c70045d36fa3561f5735bfccc --- /dev/null +++ b/pharos_dto/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2644, + "annotations_size": 1768, + "title": "Average number of proteins per term", + "value": 3.0921945701357467 +} \ No newline at end of file diff --git a/pharos_dto/paths.json b/pharos_dto/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..ffbc9531f8abac873ac3104b06a400eaf21402e4 --- /dev/null +++ b/pharos_dto/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/pharos_dto/fragment/C197/C197_val_log2fc"} \ No newline at end of file diff --git a/pharos_dto/result.tsv b/pharos_dto/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..63fcf5afb8582dba4fa484ba5d178052e8523e62 --- /dev/null +++ b/pharos_dto/result.tsv @@ -0,0 +1,61 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Receptor 0.7552580728281043 2.863728289626413 0.0041868698797613 0.9993996067803907 0.5013224967023232 21 P11717,Q8WTV0,Q9UQB8,O75787,Q9NR77,Q567V2,Q14108,A6NIH7,Q9BUN8 9 +SLC superfamily of solute carriers 0.6868310343093663 2.691928862747599 0.0071040096319032 0.999996643843824 0.5013224967023232 40 Q9HC21,Q8TB61,P12235,Q8IXU6,P05141,O95202,P53985,Q9H2V7,Q9UBX3,P08195,Q9Y619,O14975,P55011,Q99808,Q00325,Q9BXP2,Q9H2D1,Q02978,Q15758,O43772,Q70HW3,Q96H78,Q8TAD4,Q96NB2,P12236,Q5T1Q4,Q9Y6M7,Q6NUK1,Q96QD8,O95563,Q6N075,Q9NZJ7 32 +Protease inhibitor 0.8248082632798535 2.588220814955978 0.0096473115276625 0.9999999639822592 0.5013224967023232 10 P27105,P05067 2 +Signaling 0.7011838076975874 2.549232954624962 0.0107960158003379 0.9999999953719826 0.5013224967023232 18 P43490,O15173,O00264,Q96PC5,Q96GC9 5 +Oxidase 0.7065471120348328 2.454484976200507 0.01410865598669 0.999999999987704 0.5013224967023232 16 Q6ZRP7,P14406,Q15067,O43169,O15260 5 +SLC25 family of mitochondrial transporters 0.6535802721144071 2.276710837190061 0.0228034989421126 1.0 0.5013224967023232 20 Q9HC21,P12235,Q9H2D1,P12236,P05141,Q02978,Q86VD7,Q9UBX3,Q00325,Q6NUK1,O43772,Q9Y619,Q96H78,Q9NZJ7,Q70HW3 15 +Reductase 0.68485133001139 2.2759308030998624 0.0228501515178269 1.0 0.5013224967023232 15 Q9H7Z7,Q9UDW1,Q15392,Q14739,Q9UBM7 5 +Aspartic protease 0.9295904692189384 2.1925720307558665 0.0283382281043929 1.0 0.5013224967023232 4 Q8TCT8 1 +Lipase 0.8742225913662774 2.126379447374374 0.0334716776648373 1.0 0.5013224967023232 5 Q8NCC3,Q8N2A8 2 +Mitochondrial amino acid transporter subfamily 0.8679845704263804 2.1009962306655923 0.0356412971325654 1.0 0.5013224967023232 5 Q9Y619,Q96H78 2 +Phospholipase 0.8847607245390052 2.012947159228406 0.0441201885886775 1.0 0.5013224967023232 4 Q8NCC3 1 +Mitochondrial nucleotide transporter subfamily 0.7291365572023922 1.971382188388229 0.0486801768190481 1.0 0.5013224967023232 9 P12235,Q9HC21,Q9H2D1,P12236,P05141,Q6NUK1,Q70HW3 7 +SLC35 family of nucleotide sugar transporters 0.949261643316925 1.948100369239469 0.0514029546525263 1.0 0.5013224967023232 3 Q8TB61,Q5T1Q4 2 +Protease 0.4792162693470376 1.9432242563854467 0.0519890685437913 1.0 0.5013224967023232 105 Q8NHP8,Q13510,P07858,Q9HB40,Q5JRX3,Q99538,P42892,Q8TCT8,Q96FW1,O75844,O14773,Q5BJF2,P10619,Q9UIQ6,Q92820,P42785,Q9H3G5,P53634,P02786 19 +SNARE protein 0.8084613630199354 1.8981548243110151 0.0576756898639594 1.0 0.5013224967023232 6 Q9UNK0,O15400,Q9P2W9,P51809 4 +Metalloprotease 0.5740488554252354 1.880212752119247 0.0600790883443411 1.0 0.5013224967023232 37 Q10713,P02786,O95630,Q5JRX3,P55786,Q9UIQ6,Q9BYT8,O75844,P42892,O43847,Q9NZ08 11 +Esterase 0.7004616442347009 1.8323847326128335 0.0668941210582223 1.0 0.5013224967023232 9 P50897,Q9UMR5,Q969T7 3 +Calcium-binding protein 0.579601776165156 1.8270865600899984 0.0676867556782097 1.0 0.5013224967023232 19 O43852,P80303,Q02818,Q14257 4 +P-type ATPases 0.7756260084723422 1.759497446852044 0.0784930535205017 1.0 0.5013224967023232 6 P05026,P05023,P35670,P16615 4 +Galactosidase 0.9848599545798638 1.6751931388723018 0.0938963433042745 1.0 0.5013224967023232 2 P16278 1 +Extracellular structure 0.6937289428080088 1.6541039913555715 0.0981063852711363 1.0 0.5013224967023232 8 Q5KU26,O75718,Q32P28 3 +Membrane trafficking regulatory protein 0.5682229566461787 1.652462836774057 0.0984402350421822 1.0 0.5013224967023232 16 P24390,O00560,P11279 3 +Calmodulin 0.5696772305246851 1.611595946067382 0.1070498934373673 1.0 0.5013224967023232 15 Q02818,P80303,Q14257 3 +Intracellular calcium-sensing protein 0.5696772305246851 1.611595946067382 0.1070498934373673 1.0 0.5013224967023232 15 Q02818,P80303,Q14257 3 +Cysteine protease 0.5385215068815908 1.6089335299728582 0.1076308768172038 1.0 0.5013224967023232 35 Q8NHP8,P07858,Q96FW1,Q92820,Q99538,P53634 6 +Glycosidase 0.9572293716881142 1.562084850936088 0.1182680011726575 1.0 0.5037900401550672 2 P06865 1 +Ion channel 0.6998695254701988 1.5513285834443296 0.1208229602690682 1.0 0.5073990350491987 7 Q9C0H2 1 +Glycosyltransferase 0.5538807166165125 1.516654122120222 0.1293540330899032 1.0 0.5127756289303788 15 Q10472,Q10471,Q8N6G5,Q9BV10,Q16739,Q9BT22,P46977 7 +V-type ATPase 0.6363448089364396 1.5143312012945225 0.1299418588540226 1.0 0.5128062644060537 9 Q93050 1 +Hydrolase 0.4094563602632958 1.3970325351637884 0.1624037875648518 1.0 0.5440354809738083 88 P10253,P16278,O00462,P50897,Q8NCC3,Q9UMR5,Q969T7,P11117,P15586,P07686,P06865 11 +Na+/K+-ATPases 0.8087684274536028 1.3852618685587983 0.1659724088750227 1.0 0.5440565685886884 3 P05026 1 +Methyl-lysine/arginine binding protein 0.6966095869562684 1.3795542903359357 0.1677239195169204 1.0 0.5451027384299915 5 Q16637,P45973,P83916 3 +Acetyltransferase 0.5302055501766354 1.372820948074973 0.1698080167838207 1.0 0.5488493120179069 15 P23786,Q9BWD1,Q96N66,Q9H9T3 4 +Methyltransferase 0.5393091004065874 1.2993940731535183 0.1938087246338971 1.0 0.5787783998130721 12 Q08J23,P21964,Q9NZJ6,Q9BV86,P34896 5 +Chromodomain 0.6716774240018573 1.1279760621370991 0.2593300288024456 1.0 0.6341727536008958 4 P45973,P83916 2 +Growth factor 0.671336567552018 1.1265489004414146 0.2599332543940229 1.0 0.6341727536008958 4 Q96PC5 1 +Chloride channel family 0.8398940196820549 1.0850565816207454 0.2778965958513963 1.0 0.6586074818569286 2 P51790 1 +G-protein 0.466072950395023 1.0710555558180834 0.2841444503654753 1.0 0.6636969363430203 25 Q9NTK5,P11233,P61225,O95373,O00429,P04899 6 +Transporter 0.4528383812980404 1.011592669968297 0.3117328520785138 1.0 0.6861378729110619 164 P12235,Q8TB61,O15400,Q8IXU6,Q9BQE5,P53985,Q96ES6,Q9H2V7,Q9UBX3,P08195,Q9Y619,P08183,Q92544,O14975,Q9H6H4,P55011,Q8N2H4,Q99808,Q92973,Q00325,P61421,P16615,Q93050,P35670,Q9UNK0,P05026,Q9H2D1,P24539,P24390,O00560,O43760,Q15758,O43772,Q70HW3,Q96H78,Q8TAD4,Q96NB2,Q13190,P17900,Q00765,Q99523,O00186,Q15388,P11279,Q9Y487,Q9Y5P4,P12236,P05023,Q7Z3B4,Q5T1Q4,P51809,Q9NZJ7,Q9Y6M7,Q96QD8,O95563,Q6N075,Q9P2W9,Q9HD45 58 +SET domain 0.7944738834216466 0.9063127696376198 0.3647703284919426 1.0 0.7233906937303599 2 Q9H7B4 1 +SLC12 family of cation-coupled chloride transporters 0.7831188493565462 0.8626450464359732 0.3883326551573787 1.0 0.7486463394855591 2 P55011 1 +TK group 0.6741106120351807 0.8504098828058042 0.3950972434941238 1.0 0.7566906644174813 3 Q15375 1 +Ca2+-ATPases 0.7781983345950019 0.8438777514594624 0.3987377219064421 1.0 0.7588824870109281 2 P16615 1 +Transaminase 0.5755522470864908 0.7341317818257382 0.4628684252039448 1.0 0.8150600561806641 4 O15269 1 +Protein methyltransferase 0.5083572321927254 0.5983247747206915 0.5496232488153616 1.0 0.8730643548340514 6 Q9H7B4 1 +Small GTPase 0.3901369915806621 0.5913818804904225 0.5542645782093771 1.0 0.8742755085890771 19 O95373,P11233,O00429,P61225 4 +CAMK group 0.4921074060763057 0.5160386295021544 0.6058274294585588 1.0 0.9016017637060032 5 P54619,Q14012 2 +SLC56 Sideroflexins 0.6843300529901543 0.5111260994780917 0.6092627614596478 1.0 0.9021705065235972 2 Q96NB2 1 +Decarboxylase 0.5743754318925981 0.493518179274668 0.6216464979113157 1.0 0.9062882408392372 3 P48163 1 +Serine protease 0.3797101988890307 0.4659893108798297 0.6412231517315341 1.0 0.9152708192202992 27 Q9HB40,P10619,P42785,Q9H3G5,O14773 5 +Translation initiation factor 0.3682447529594183 0.4400014885193419 0.6599360292319867 1.0 0.9231610409954148 20 P55010,O75153,Q9Y262 3 +Cell adhesion 0.4914519288859307 0.4238781964792091 0.6716546460693646 1.0 0.9248032923924084 4 Q14574 1 +Cadherin 0.5231767518201947 0.3400572383522252 0.7338134236140064 1.0 0.9438366319091196 3 Q14574 1 +Endoribonuclease 0.4323607427055791 0.3013154078395775 0.7631739928149175 1.0 0.9448820863422788 5 Q9UKF6,Q9H9J2,O75792,Q5TA45 4 +Oxidoreductase 0.323099147495347 0.2360679438228256 0.8133799481201123 1.0 0.9561203466235668 100 Q6ZRP7,Q9H7Z7,Q9UDW1,O95881,Q16850,O15260,P49189,O75845,O43169,Q14739,Q9BV57,Q8N4Q0,Q9UBM7,Q15392,P14406,Q96CU9,O75306,Q14534,Q13423,P00367,Q15067 21 +Translation elongation factor 0.4219696969697086 0.2189416146407574 0.8266955289959397 1.0 0.9561203466235668 4 P24534,Q53EL6,P43897 3 +Translation factor 0.3329738897210921 0.174828214615048 0.8612146177002804 1.0 0.9561203466235668 25 P55010,O75153,Q9Y262 3 +ATP-binding cassette transporter family 0.4117905131299706 0.1156828356573919 0.9079039100715928 1.0 0.9575511421520676 3 P08183 1 +Kinase activator 0.3386363636363675 0.0640437025841316 0.9489354285808193 1.0 0.9703330459482724 4 O95067,Q16543,P14635 3 +Nucleotide kinase 0.3227272727272804 0.0463618170907708 0.9630218693172596 1.0 0.9718165895849972 4 P00568,P54819,Q9UIJ7 3 diff --git a/pharos_dto/selections.json b/pharos_dto/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..82a76eaedfe0d0f3a490e025db0ff55cc6acbdf9 --- /dev/null +++ b/pharos_dto/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase", "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1", "10 kDa heat shock protein, mitochondrial", "116 kDa U5 small nuclear ribonucleoprotein component", "14-3-3 protein beta/alpha", "14-3-3 protein epsilon", "14-3-3 protein eta", "14-3-3 protein gamma", "14-3-3 protein theta", "14-3-3 protein zeta/delta", "2',3'-cyclic-nucleotide 3'-phosphodiesterase", "2',5'-phosphodiesterase 12", "2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial", "2-hydroxyacyl-CoA lyase 1", "26S proteasome non-ATPase regulatory subunit 1", "26S proteasome non-ATPase regulatory subunit 12", "26S proteasome non-ATPase regulatory subunit 13", "26S proteasome non-ATPase regulatory subunit 14", "26S proteasome non-ATPase regulatory subunit 2", "26S proteasome non-ATPase regulatory subunit 3", "26S proteasome non-ATPase regulatory subunit 4", "26S proteasome non-ATPase regulatory subunit 7", "26S proteasome non-ATPase regulatory subunit 8", "26S proteasome regulatory subunit 10B", "26S proteasome regulatory subunit 4", "26S proteasome regulatory subunit 6A", "26S proteasome regulatory subunit 6B", "26S proteasome regulatory subunit 7", "26S proteasome regulatory subunit 8", "28S ribosomal protein S11, mitochondrial", "28S ribosomal protein S2, mitochondrial", "28S ribosomal protein S27, mitochondrial", "28S ribosomal protein S29, mitochondrial", "28S ribosomal protein S35, mitochondrial", "28S ribosomal protein S5, mitochondrial", "28S ribosomal protein S7, mitochondrial", "3'(2'),5'-bisphosphate nucleotidase 1", "3'-5' exoribonuclease 1", "3-hydroxyacyl-CoA dehydrogenase type-2", "3-hydroxyisobutyrate dehydrogenase, mitochondrial", "3-hydroxyisobutyryl-CoA hydrolase, mitochondrial", "3-ketoacyl-CoA thiolase, mitochondrial", "3-mercaptopyruvate sulfurtransferase", "39S ribosomal protein L1, mitochondrial", "39S ribosomal protein L11, mitochondrial", "39S ribosomal protein L12, mitochondrial", "39S ribosomal protein L14, mitochondrial", "39S ribosomal protein L19, mitochondrial", "39S ribosomal protein L21, mitochondrial", "39S ribosomal protein L38, mitochondrial", "39S ribosomal protein L39, mitochondrial", "39S ribosomal protein L44, mitochondrial", "39S ribosomal protein L47, mitochondrial", "39S ribosomal protein L48, mitochondrial", "39S ribosomal protein L49, mitochondrial", "39S ribosomal protein L9, mitochondrial", "4-trimethylaminobutyraldehyde dehydrogenase", "40S ribosomal protein S10", "40S ribosomal protein S11", "40S ribosomal protein S12", "40S ribosomal protein S13", "40S ribosomal protein S14", "40S ribosomal protein S15a", "40S ribosomal protein S17", "40S ribosomal protein S18", "40S ribosomal protein S19", "40S ribosomal protein S2", "40S ribosomal protein S20", "40S ribosomal protein S21", "40S ribosomal protein S23", "40S ribosomal protein S24", "40S ribosomal protein S3", "40S ribosomal protein S3a", "40S ribosomal protein S4, X isoform", "40S ribosomal protein S5", "40S ribosomal protein S6", "40S ribosomal protein S7", "40S ribosomal protein S8", "40S ribosomal protein S9", "40S ribosomal protein SA", "45 kDa calcium-binding protein", "4F2 cell-surface antigen heavy chain", "5'-AMP-activated protein kinase subunit gamma-1", "5'-nucleotidase domain-containing protein 1", "5'-nucleotidase domain-containing protein 2", "6-phosphogluconate dehydrogenase, decarboxylating", "6-phosphogluconolactonase", "60 kDa SS-A/Ro ribonucleoprotein", "60S ribosomal protein L10", "60S ribosomal protein L10a", "60S ribosomal protein L11", "60S ribosomal protein L12", "60S ribosomal protein L13", "60S ribosomal protein L13a", "60S ribosomal protein L14", "60S ribosomal protein L15", "60S ribosomal protein L18", "60S ribosomal protein L19", "60S ribosomal protein L21", "60S ribosomal protein L22", "60S ribosomal protein L23", "60S ribosomal protein L23a", "60S ribosomal protein L24", "60S ribosomal protein L26", "60S ribosomal protein L27", "60S ribosomal protein L27a", "60S ribosomal protein L28", "60S ribosomal protein L29", "60S ribosomal protein L3", "60S ribosomal protein L30", "60S ribosomal protein L31", "60S ribosomal protein L32", "60S ribosomal protein L35", "60S ribosomal protein L35a", "60S ribosomal protein L36", "60S ribosomal protein L36a", "60S ribosomal protein L37", "60S ribosomal protein L38", "60S ribosomal protein L5", "60S ribosomal protein L6", "60S ribosomal protein L7", "60S ribosomal protein L7-like 1", "60S ribosomal protein L7a", "60S ribosomal protein L8", "60S ribosomal protein L9", "7,8-dihydro-8-oxoguanine triphosphatase", "7-dehydrocholesterol reductase", "7-methylguanosine phosphate-specific 5'-nucleotidase", "A-kinase anchor protein 1, mitochondrial", "ABCB subfamily", "ABCD subfamily of peroxisomal ABC transporters", "ADP-dependent glucokinase", "ADP-sugar pyrophosphatase", "ADP/ATP translocase 1", "ADP/ATP translocase 2", "ADP/ATP translocase 3", "AFG3-like protein 2", "AGC group", "AH receptor-interacting protein", "AK1 subfamily", "AK2 subfamily", "AK3 subfamily", "AKT family", "AP-1 complex subunit beta-1", "AP-1 complex subunit gamma-1", "AP-1 complex subunit mu-1", "AP-1 complex subunit sigma-2", "AP-2 complex subunit alpha-1", "AP-2 complex subunit beta", "AP-2 complex subunit mu", "AP-2 complex subunit sigma", "AP-3 complex subunit beta-1", "AP-3 complex subunit delta-1", "AP-3 complex subunit mu-1", "AT-rich interactive domain-containing protein 3B", "ATP synthase F(0) complex subunit B1, mitochondrial", "ATP synthase mitochondrial F1 complex assembly factor 1", "ATP synthase subunit a", "ATP synthase subunit alpha, mitochondrial", "ATP synthase subunit beta, mitochondrial", "ATP synthase subunit d, mitochondrial", "ATP synthase subunit e, mitochondrial", "ATP synthase subunit f, mitochondrial", "ATP synthase subunit gamma, mitochondrial", "ATP-binding cassette sub-family B member 7, mitochondrial", "ATP-binding cassette sub-family D member 3", "ATP-binding cassette sub-family F member 1", "ATP-binding cassette sub-family F member 2", "ATP-binding cassette sub-family F member 3", "ATP-binding cassette transporter family", "ATP-citrate synthase", "ATP-dependent 6-phosphofructokinase, muscle type", "ATP-dependent 6-phosphofructokinase, platelet type", "ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial", "ATP-dependent DNA helicase Q1", "ATP-dependent PFK group I subfamily", "ATP-dependent RNA helicase A", "ATP-dependent RNA helicase DHX29", "ATP-dependent RNA helicase DHX8", "ATP-dependent zinc metalloprotease YME1L1", "ATPase ASNA1", "ATPase family AAA domain-containing protein 3A", "ATPase family AAA domain-containing protein 3B", "ATPase inhibitor, mitochondrial", "AUR family", "Abl interactor 1", "Acetolactate synthase-like protein", "Acetyl-CoA acetyltransferase, cytosolic", "Acetyl-CoA acetyltransferase, mitochondrial", "Acetyltransferase", "Acid ceramidase", "Acidic leucine-rich nuclear phosphoprotein 32 family member A", "Acidic leucine-rich nuclear phosphoprotein 32 family member B", "Aconitate hydratase, mitochondrial", "Actin and actin related protein", "Actin binding motor protein", "Actin family cytoskeletal protein", "Actin-like protein 6A", "Actin-related protein 2", "Actin-related protein 2/3 complex subunit 1A", "Actin-related protein 2/3 complex subunit 3", "Actin-related protein 2/3 complex subunit 4", "Actin-related protein 3", "Acyl-CoA dehydrogenase family member 9, mitochondrial", "Acyl-CoA synthetase family member 3, mitochondrial", "Acyl-coenzyme A thioesterase 9, mitochondrial", "Acylamino-acid-releasing enzyme", "Acylpyruvase FAHD1, mitochondrial", "Acyltransferase", "Adenosine 3'-phospho 5'-phosphosulfate transporter 1", "Adenosine kinase", "Adenosylhomocysteinase", "Adenylate kinase 2, mitochondrial", "Adenylate kinase family", "Adenylate kinase isoenzyme 1", "Adenylosuccinate lyase", "Adenylosuccinate synthetase isozyme 2", "Adenylyl cyclase-associated protein 1", "Afadin", "Aflatoxin B1 aldehyde reductase member 2", "Alanine--tRNA ligase, cytoplasmic", "Alanine--tRNA ligase, mitochondrial", "Alanine/serine/cysteine transporter subfamily", "Alcohol dehydrogenase [NADP(+)]", "Alcohol dehydrogenase class-3", "Aldehyde dehydrogenase X, mitochondrial", "Aldehyde dehydrogenase family 16 member A1", "Aldehyde dehydrogenase, mitochondrial", "Aldose 1-epimerase", "Aldose reductase", "Alpha-adducin", "Alpha-aminoadipic semialdehyde dehydrogenase", "Alpha-centractin", "Alpha-enolase", "Alpha-globin transcription factor CP2", "Alpha-soluble NSF attachment protein", "Alpha-taxilin", "Amidophosphoribosyltransferase", "Aminoacyl tRNA synthase complex-interacting multifunctional protein 1", "Aminoacyl-tRNA synthetase", "Amyloid-beta A4 protein", "Amyloid-like protein 2", "Anaphase-promoting complex subunit 1", "Anaphase-promoting complex subunit 10", "Ancient ubiquitous protein 1", "Anion channel tweety (tweety) family", "Annexin", "Antibacterial response protein", "Apolipoprotein", "Apolipoprotein L2", "Apoptosis-inducing factor 1, mitochondrial", "Apoptosis-stimulating of p53 protein 2", "Arfaptin-1", "Arfaptin-2", "Arylsulfatase A", "Asparagine synthetase [glutamine-hydrolyzing]", "Asparagine--tRNA ligase, cytoplasmic", "Aspartate--tRNA ligase, cytoplasmic", "Aspartate--tRNA ligase, mitochondrial", "Aspartic protease", "Ataxin-2-like protein", "Atlastin-2", "Atp-dependent 6-phosphofructokinase, liver type", "Atypical group", "Aurora kinase a", "B-cell receptor-associated protein 31", "BTB/POZ domain-containing protein KCTD12", "BUB family", "Basic leucine zipper and W2 domain-containing protein 1", "Basic leucine zipper and W2 domain-containing protein 2", "Bcl-2-associated transcription factor 1", "Beta-galactosidase", "Beta-hexosaminidase subunit alpha", "Beta-hexosaminidase subunit beta", "Beta-mannosidase", "Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1", "Bifunctional epoxide hydrolase 2", "Bifunctional glutamate/proline--tRNA ligase", "Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial", "Bifunctional purine biosynthesis protein PURH", "Biliverdin reductase A", "Biotin--protein ligase", "Bleomycin hydrolase", "Brain-specific angiogenesis inhibitor 1-associated protein 2", "Bromodomain", "Bromodomain-containing protein 2", "C-1-tetrahydrofolate synthase, cytoplasmic", "C-Jun-amino-terminal kinase-interacting protein 4", "C-terminal-binding protein 1", "C-terminal-binding protein 2", "C2H2 zinc finger transcription factor", "CAAX prenyl protease 1 homolog", "CAD protein", "CAMK group", "CAMK1 family", "CAMK2 family", "CAMKL family", "CAP-Gly domain-containing linker protein 1", "CASK family", "CCAAT/enhancer-binding protein zeta", "CCK4 family", "CCR4-NOT transcription complex subunit 1", "CCR4-NOT transcription complex subunit 2", "CCR4-NOT transcription complex subunit 3", "CCR4-NOT transcription complex subunit 4", "CCR4-NOT transcription complex subunit 7", "CDK family", "CDK1 subfamily", "CDK4 subfamily", "CDK5 subfamily", "CDKN2A-interacting protein", "CK1 family", "CK1 group", "CK2 family", "CLIP-associating protein 1", "CLIP-associating protein 2", "CMGC group", "COP9 signalosome complex subunit 3", "COP9 signalosome complex subunit 5", "COP9 signalosome complex subunit 6", "COP9 signalosome complex subunit 8", "CSK family", "CTP synthase 1", "CTP synthase 2", "Ca2+-ATPases", "Cadherin", "Calcium homeostasis endoplasmic reticulum protein", "Calcium uniporter protein, mitochondrial", "Calcium uptake protein 1, mitochondrial", "Calcium-binding mitochondrial carrier protein Aralar1", "Calcium-binding mitochondrial carrier protein Aralar2", "Calcium-binding mitochondrial carrier protein SCaMC-1", "Calcium-binding protein", "Calcium-binding protein 39", "Calcium-transporting ATPase type 2C member 1", "Calcium/calmodulin-dependent protein kinase type 1", "Calcium/calmodulin-dependent protein kinase type ii subunit gamma", "Calcyclin-binding protein", "Calmegin", "Calmodulin", "Calmodulin-3", "Calnexin", "Calpain-1 catalytic subunit", "Calpain-2 catalytic subunit", "Calponin-2", "Calponin-3", "Calreticulin", "Calumenin", "Cancer-related nucleoside-triphosphatase", "Caprin-1", "Carbohydrate kinase", "Carbohydrate sulfotransferase 14", "Carnitine O-palmitoyltransferase 2, mitochondrial", "Cartilage-associated protein", "Casein kinase II subunit alpha", "Casein kinase II subunit alpha'", "Casein kinase i isoform alpha", "Casein kinase ii subunit beta", "Catechol O-methyltransferase", "Catenin alpha-1", "Catenin delta-1", "Cathepsin B", "Cation-dependent mannose-6-phosphate receptor", "Cation-independent mannose-6-phosphate receptor", "Cell adhesion", "Cell cycle and apoptosis regulator protein 2", "Cell division control protein 42 homolog", "Cell division cycle and apoptosis regulator protein 1", "Cell division cycle protein 20 homolog", "Cell-cell junction", "Cellular structure", "Cellular tumor antigen p53", "Centrin-2", "Centromere/kinetochore protein zw10 homolog", "Ceramide glucosyltransferase", "Chaperone", "Chaperonin", "Charged multivesicular body protein 7", "Chitobiosyldiphosphodolichol beta-mannosyltransferase", "Chloride channel CLIC-like protein 1", "Chloride channel family", "Chloride intracellular channel protein 1", "Chloride intracellular channel protein 4", "Choline kinase alpha", "Choline/ethanolamine kinase family", "Choline/ethanolaminephosphotransferase 1", "Chondroitin sulfate N-acetylgalactosaminyltransferase 2", "Chromatin accessibility complex protein 1", "Chromatin assembly factor 1 subunit A", "Chromatin assembly factor 1 subunit B", "Chromatin/chromatin-binding protein", "Chromobox protein homolog 1", "Chromobox protein homolog 2", "Chromobox protein homolog 3", "Chromobox protein homolog 5", "Chromodomain", "Chromosome-associated kinesin KIF4A", "Cilia- and flagella-associated protein 20", "Citrate synthase, mitochondrial", "ClC-3/CLCN3 subfamily", "ClC-7/CLCN7 subfamily", "Clathrin heavy chain 1", "Cleavage and polyadenylation specificity factor subunit 1", "Cleavage and polyadenylation specificity factor subunit 3", "Cleavage and polyadenylation specificity factor subunit 5", "Cleavage and polyadenylation specificity factor subunit 6", "Cleavage and polyadenylation specificity factor subunit 7", "Cleavage stimulation factor subunit 2", "Cleavage stimulation factor subunit 3", "Cleft lip and palate transmembrane protein 1", "Cleft lip and palate transmembrane protein 1-like protein", "Clustered mitochondria protein homolog", "Coactosin-like protein", "Coatomer subunit alpha", "Coatomer subunit beta", "Coatomer subunit beta'", "Coatomer subunit delta", "Coatomer subunit epsilon", "Coatomer subunit gamma-1", "Coatomer subunit gamma-2", "Coatomer subunit zeta-1", "Cohesin subunit SA-2", "Coilin", "Cold-inducible RNA-binding protein", "Collagen type IV alpha-3-binding protein", "Collectin-12", "Condensin complex subunit 1", "Copper-transporting ATPase 2", "Core histone macro-H2A.1", "Core histone macro-H2A.2", "Coronin-1A", "Coronin-1C", "Coronin-7", "Creatine kinase B-type", "Creatine kinase U-type, mitochondrial", "Crooked neck-like protein 1", "Cu+-ATPases", "Cullin-1", "Cullin-2", "Cullin-4B", "Cullin-5", "Cullin-associated NEDD8-dissociated protein 1", "Cullin-associated NEDD8-dissociated protein 2", "Cyclase", "Cyclin-dependent kinase 1", "Cyclin-dependent kinase 2", "Cyclin-dependent kinase 4", "Cyclin-dependent kinase 6", "Cyclin-dependent-like kinase 5", "Cyclin-g-associated kinase", "Cystathionine gamma-lyase", "Cystatin-B", "Cysteine and histidine-rich domain-containing protein 1", "Cysteine protease", "Cysteine protease inhibitor", "Cysteine--tRNA ligase, cytoplasmic", "Cytochrome b-c1 complex subunit 1, mitochondrial", "Cytochrome b-c1 complex subunit 2, mitochondrial", "Cytochrome b-c1 complex subunit 9", "Cytochrome b5 type B", "Cytochrome c oxidase subunit 2", "Cytochrome c oxidase subunit 5A, mitochondrial", "Cytochrome c oxidase subunit 7A2, mitochondrial", "Cytochrome c oxidase subunit NDUFA4", "Cytochrome c-type heme lyase", "Cytokine", "Cytoplasmic FMR1-interacting protein 1", "Cytoplasmic dynein 1 heavy chain 1", "Cytoplasmic dynein 1 light intermediate chain 1", "Cytoplasmic dynein 1 light intermediate chain 2", "Cytoplasmic dynein 2 heavy chain 1", "Cytoskeleton-associated protein 5", "Cytosol aminopeptidase", "Cytosolic acyl coenzyme A thioester hydrolase", "Cytosolic non-specific dipeptidase", "Cytosolic purine 5'-nucleotidase", "D-3-phosphoglycerate dehydrogenase", "D-dopachrome decarboxylase", "DMPK family", "DNA (cytosine-5)-methyltransferase 1", "DNA binding protein", "DNA damage-binding protein 1", "DNA glycosylase", "DNA helicase", "DNA ligase", "DNA ligase 1", "DNA ligase 3", "DNA methyltransferase", "DNA mismatch repair protein Msh2", "DNA mismatch repair protein Msh3", "DNA mismatch repair protein Msh6", "DNA polymerase alpha subunit B", "DNA polymerase delta subunit 2", "DNA polymerase epsilon subunit 4", "DNA polymerase processivity factor", "DNA primase small subunit", "DNA replication licensing factor MCM2", "DNA replication licensing factor MCM3", "DNA replication licensing factor MCM4", "DNA replication licensing factor MCM5", "DNA replication licensing factor MCM6", "DNA replication licensing factor MCM7", "DNA topoisomerase", "DNA topoisomerase 1", "DNA-directed DNA polymerase", "DNA-directed RNA polymerase", "DNA-directed RNA polymerase I subunit RPA1", "DNA-directed RNA polymerase I subunit RPA2", "DNA-directed RNA polymerase II subunit RPB1", "DNA-directed RNA polymerase II subunit RPB2", "DNA-directed RNA polymerase II subunit RPB3", "DNA-directed RNA polymerase II subunit RPB7", "DNA-directed RNA polymerase III subunit RPC1", "DNA-directed RNA polymerase III subunit RPC3", "DNA-directed RNA polymerase, mitochondrial", "DNAPK subfamily", "DYRK family", "Damaged DNA-binding protein", "Deacetylase", "Deaminase", "Death-inducer obliterator 1", "Decarboxylase", "Dedicator of cytokinesis protein 7", "Dehydratase", "Dehydrogenase", "Delta(24)-sterol reductase", "Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial", "Delta-1-pyrroline-5-carboxylate synthase", "Density-regulated protein", "Deoxyribonuclease-2-alpha", "Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial", "Derlin-1", "Desmocollin-1", "Desmocollin-3", "Desmoglein-2", "Desmoplakin", "Digestive organ expansion factor homolog", "Dihydrofolate reductase", "Dihydrolipoyl dehydrogenase, mitochondrial", "Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial", "Dihydropteridine reductase", "Dihydropyrimidinase-related protein 2", "Dihydropyrimidinase-related protein 5", "Dipeptidyl peptidase 1", "Dipeptidyl peptidase 3", "Dipeptidyl peptidase 9", "Diphthine methyl ester synthase", "Dna-dependent protein kinase catalytic subunit", "Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase", "Dolichol-phosphate mannosyltransferase subunit 1", "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit", "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1", "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2", "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A", "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B", "Double-stranded RNA-specific adenosine deaminase", "Drebrin", "Drebrin-like protein", "Dual specificity mitogen-activated protein kinase kinase 1", "Dual specificity protein kinase ttk", "Dynactin subunit 1", "Dynactin subunit 2", "Dynamin-1-like protein", "Dynamin-2", "Dynamin-like 120 kDa protein, mitochondrial", "Dynein light chain 1, cytoplasmic", "Dystonin", "E3 SUMO-protein ligase RanBP2", "E3 ubiquitin-protein ligase ARIH1", "E3 ubiquitin-protein ligase ARIH2", "E3 ubiquitin-protein ligase CBL", "E3 ubiquitin-protein ligase HUWE1", "E3 ubiquitin-protein ligase RBBP6", "E3 ubiquitin-protein ligase listerin", "EF-hand domain-containing protein D1", "EH domain-containing protein 1", "EH domain-containing protein 4", "ELMO domain-containing protein 2", "ER lumen protein-retaining receptor 1", "ER membrane protein complex subunit 2", "ERK subfamily", "ERO1-like protein alpha", "Electron transfer flavoprotein subunit alpha, mitochondrial", "Electron transfer flavoprotein subunit beta", "Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial", "Elongation factor 1-alpha 2", "Elongation factor 1-beta", "Elongation factor 1-delta", "Elongation factor 2", "Elongation factor Ts, mitochondrial", "Elongation factor Tu, mitochondrial", "Elongation factor-like GTPase 1", "Elongator complex protein 1", "Elongator complex protein 3", "Elongin-B", "Elongin-C", "Endodeoxyribonuclease", "Endonuclease III-like protein 1", "Endoplasmic reticulum aminopeptidase 1", "Endoplasmic reticulum metallopeptidase 1", "Endoplasmic reticulum protein SC65", "Endoplasmic reticulum resident protein 29", "Endoplasmin", "Endoribonuclease", "Endothelin-converting enzyme 1", "Engulfment and cell motility protein 2", "Enhancer of mRNA-decapping protein 4", "Enhancer of rudimentary homolog", "Enoyl-CoA delta isomerase 1, mitochondrial", "Enoyl-CoA delta isomerase 2, mitochondrial", "Enoyl-CoA hydratase, mitochondrial", "Enzyme", "Enzyme modulator", "Eph family", "Ephrin type-a receptor 7", "Epidermal growth factor receptor substrate 15", "Epidermal growth factor receptor substrate 15-like 1", "Epigenetic regulator", "Epimerase family protein SDR39U1", "Epimerase/racemase", "Epiplakin", "Equilibrative nucleoside transporter 1", "Eraser", "Erythrocyte band 7 integral membrane protein", "Esterase", "Eukaryotic peptide chain release factor GTP-binding subunit ERF3A", "Eukaryotic peptide chain release factor subunit 1", "Eukaryotic translation initiation factor 2 subunit 1", "Eukaryotic translation initiation factor 2 subunit 2", "Eukaryotic translation initiation factor 2A", "Eukaryotic translation initiation factor 2D", "Eukaryotic translation initiation factor 3 subunit A", "Eukaryotic translation initiation factor 3 subunit B", "Eukaryotic translation initiation factor 3 subunit D", "Eukaryotic translation initiation factor 3 subunit E", "Eukaryotic translation initiation factor 3 subunit F", "Eukaryotic translation initiation factor 3 subunit H", "Eukaryotic translation initiation factor 3 subunit I", "Eukaryotic translation initiation factor 3 subunit J", "Eukaryotic translation initiation factor 3 subunit L", "Eukaryotic translation initiation factor 4 gamma 1", "Eukaryotic translation initiation factor 4 gamma 2", "Eukaryotic translation initiation factor 4 gamma 3", "Eukaryotic translation initiation factor 4B", "Eukaryotic translation initiation factor 4E", "Eukaryotic translation initiation factor 4H", "Eukaryotic translation initiation factor 5", "Eukaryotic translation initiation factor 5A-1", "Eukaryotic translation initiation factor 5B", "Exocyst complex component 3", "Exocyst complex component 5", "Exocyst complex component 7", "Exodeoxyribonuclease", "Exonuclease 1", "Exoribonuclease", "Exosome complex component MTR3", "Exosome complex component RRP4", "Exosome complex component RRP40", "Exosome complex component RRP42", "Exosome complex component RRP46", "Exosome complex exonuclease RRP44", "Exportin-1", "Exportin-2", "Exportin-4", "Exportin-5", "Exportin-7", "Exportin-T", "Extracellular matrix glycoprotein", "Extracellular matrix structural protein", "Extracellular structure", "Ezrin", "F-actin-capping protein subunit alpha-1", "F-actin-capping protein subunit alpha-2", "F-actin-capping protein subunit beta", "F-type ATPase", "F-type and V-type ATPases", "FACT complex subunit SPT16", "FAD-dependent oxidoreductase domain-containing protein 1", "FRAP subfamily", "FRAY subfamily", "Far upstream element-binding protein 1", "Far upstream element-binding protein 2", "Far upstream element-binding protein 3", "Farnesyl pyrophosphate synthase", "Fascin", "Fatty acid synthase", "Ferrochelatase, mitochondrial", "Flap endonuclease 1", "Fragile X mental retardation syndrome-related protein 1", "Fragile X mental retardation syndrome-related protein 2", "Fumarate hydratase, mitochondrial", "G patch domain-containing protein 4", "G-patch domain and KOW motifs-containing protein", "G-protein", "G-protein coupled receptor", "G-protein modulator", "G-rich sequence factor 1", "G2/mitotic-specific cyclin-B1", "G2/mitotic-specific cyclin-B2", "GC-rich sequence DNA-binding factor 2", "GHMP kinase family", "GMP synthase [glutamine-hydrolyzing]", "GSK family", "GSK subfamily", "GTP-binding nuclear protein Ran", "GTP-binding protein 1", "GTP-binding protein Rheb", "GTPase Era, mitochondrial", "GTPase-activating protein and VPS9 domain-containing protein 1", "Galactokinase", "Galactosidase", "Galectin-3", "Gamma-adducin", "Gamma-aminobutyric acid receptor-associated protein-like 2", "Gamma-enolase", "Gamma-glutamyl hydrolase", "Gamma-taxilin", "Gamma-tubulin complex component 2", "Gamma-tubulin complex component 3", "Ganglioside GM2 activator", "General transcription factor 3C polypeptide 3", "General vesicular transport factor p115", "Geranylgeranyl transferase type-1 subunit beta", "Geranylgeranyl transferase type-2 subunit alpha", "Glia maturation factor beta", "Glucosamine-6-phosphate isomerase 1", "Glucose-6-phosphate 1-dehydrogenase", "Glucose-6-phosphate isomerase", "Glucosidase", "Glucosidase 2 subunit beta", "Glutamate dehydrogenase 1, mitochondrial", "Glutamate--cysteine ligase catalytic subunit", "Glutamate--cysteine ligase regulatory subunit", "Glutaminase kidney isoform, mitochondrial", "Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1", "Glutamine--tRNA ligase", "Glutaredoxin-3", "Glutaredoxin-related protein 5, mitochondrial", "Glutathione reductase, mitochondrial", "Glutathione synthetase", "Glyceraldehyde-3-phosphate dehydrogenase", "Glycerol-3-phosphate dehydrogenase, mitochondrial", "Glycerol-3-phosphate phosphatase", "Glycine dehydrogenase (decarboxylating), mitochondrial", "Glycine--tRNA ligase", "Glycogen debranching enzyme", "Glycogen phosphorylase, brain form", "Glycogen phosphorylase, liver form", "Glycogen synthase kinase-3 beta", "Glycosidase", "Glycosylase", "Glycosyltransferase", "Glycylpeptide N-tetradecanoyltransferase 1", "Glyoxylate reductase/hydroxypyruvate reductase", "Group XV phospholipase A2", "Growth factor", "GrpE protein homolog 1, mitochondrial", "Gtp:amp phosphotransferase ak3, mitochondrial", "Guanine nucleotide-binding protein G(i) subunit alpha-1", "Guanine nucleotide-binding protein G(i) subunit alpha-2", "Guanine nucleotide-binding protein G(k) subunit alpha", "Guanine nucleotide-binding protein subunit alpha-13", "Guanyl-nucleotide exchange factor", "H(+)/Cl(-) exchange transporter 3", "H(+)/Cl(-) exchange transporter 7", "H/ACA ribonucleoprotein complex subunit 1", "H/ACA ribonucleoprotein complex subunit 2", "HBS1-like protein", "HDAC class I", "HEAT repeat-containing protein 1", "Haloacid dehalogenase-like hydrolase domain-containing 5", "Haloacid dehalogenase-like hydrolase domain-containing protein 2", "Heat shock protein 75 kDa, mitochondrial", "Heat shock protein HSP 90-alpha", "Heat shock protein HSP 90-beta", "Helicase", "Helix-turn-helix transcription factor", "Hepatoma-derived growth factor", "Hepatoma-derived growth factor-related protein 2", "Heterogeneous nuclear ribonucleoprotein F", "Heterogeneous nuclear ribonucleoprotein H", "Heterogeneous nuclear ribonucleoprotein H2", "Heterogeneous nuclear ribonucleoprotein H3", "Heterogeneous nuclear ribonucleoprotein K", "Heterogeneous nuclear ribonucleoprotein M", "Heterogeneous nuclear ribonucleoprotein Q", "Heterogeneous nuclear ribonucleoprotein R", "Heterotrimeric G-protein", "Hexokinase family", "Hexokinase-1", "Hexokinase-2", "High mobility group protein B1", "High mobility group protein B2", "High mobility group protein B3", "High mobility group protein HMG-I/HMG-Y", "Histone", "Histone H1.0", "Histone H1.2", "Histone H1.3", "Histone H1.4", "Histone H1x", "Histone H2AX", "Histone H4", "Histone acetyltransferase type B catalytic subunit", "Histone deacetylase", "Histone deacetylase 2", "Histone deacetylase complex subunit SAP18", "Histone-arginine methyltransferase CARM1", "Histone-lysine N-methyltransferase NSD2", "Histone-lysine N-methyltransferase SMYD3", "Homeobox protein CDX-2", "Homeodomain transcription factor", "Hormone", "Hsp90 co-chaperone Cdc37", "Hsp90 family chaperone", "Hydrolase", "Hydroxylase", "Hypoxanthine-guanine phosphoribosyltransferase", "IKK family", "Immune response", "Immunoglobulin fold transcription factor", "Immunoglobulin-binding protein 1", "Importin subunit alpha-1", "Importin subunit alpha-4", "Importin subunit alpha-5", "Importin subunit beta-1", "Importin-4", "Importin-5", "Importin-7", "Importin-8", "Importin-9", "Inactive tyrosine-protein kinase 7", "Induced myeloid leukemia cell differentiation protein Mcl-1", "Inhibitor of nuclear factor kappa-b kinase subunit alpha", "Inorganic pyrophosphatase", "Inorganic pyrophosphatase 2, mitochondrial", "Inosine triphosphate pyrophosphatase", "Inosine-5'-monophosphate dehydrogenase 1", "Inosine-5'-monophosphate dehydrogenase 2", "Inositol polyphosphate 5-phosphatase OCRL-1", "Insulin-degrading enzyme", "Insulin-like growth factor 2 mRNA-binding protein 1", "Insulin-like growth factor 2 mRNA-binding protein 2", "Insulin-like growth factor 2 mRNA-binding protein 3", "Integrator complex subunit 11", "Integrin beta-1", "Integrin-linked kinase-associated serine/threonine phosphatase 2C", "Interferon-induced, double-stranded rna-activated protein kinase", "Interferon-inducible double-stranded rna-dependent protein kinase activator a", "Interleukin enhancer-binding factor 3", "Intermediate filament", "Intermediate filament binding protein", "Intracellular calcium-sensing protein", "Intracellular chloride channel (clic) family", "Intracellular chloride channel (icc) family", "Ion channel", "Isoaspartyl peptidase/L-asparaginase", "Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial", "Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial", "Isoleucine--tRNA ligase, cytoplasmic", "Isoleucine--tRNA ligase, mitochondrial", "Isomerase", "Isopentenyl-diphosphate Delta-isomerase 1", "Isovaleryl-CoA dehydrogenase, mitochondrial", "Jumonji domain-containing", "KH domain-containing, RNA-binding, signal transduction-associated protein 1", "KRAB box transcription factor", "KRR1 small subunit processome component homolog", "Ketosamine-3-kinase", "Kinase", "Kinase activator", "Kinase inhibitor", "Kinase modulator", "Kinesin-1 heavy chain", "Kinesin-like protein KIF11", "Kinesin-like protein KIF15", "Kinesin-like protein KIF18B", "Kinesin-like protein KIF20A", "Kinesin-like protein KIF22", "Kinesin-like protein KIF23", "Kinesin-like protein KIF2A", "Kinesin-like protein KIF2C", "Kinesin-like protein KIF7", "Kinesin-like protein KIFC1", "Kinetochore protein Nuf2", "L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase", "L-lactate dehydrogenase A chain", "L-lactate dehydrogenase B chain", "LIM domain and actin-binding protein 1", "LU7TM family", "La-related protein 1", "La-related protein 4", "La-related protein 4B", "Lamin-B receptor", "Lamina-associated polypeptide 2, isoform alpha", "Lanosterol 14-alpha demethylase", "Large proline-rich protein BAG6", "Lathosterol oxidase", "Legumain", "Lethal(2) giant larvae protein homolog 1", "Leucine-rich repeat and WD repeat-containing protein 1", "Leucine-rich repeat-containing protein 47", "Leucyl-cystinyl aminopeptidase", "Ligase", "Lipase", "Lipid kinase", "Lon protease homolog, mitochondrial", "Long-chain fatty acid transport protein 4", "Long-chain-fatty-acid--CoA ligase 1", "Long-chain-fatty-acid--CoA ligase 3", "Long-chain-fatty-acid--CoA ligase 4", "Lupus La protein", "Lyase", "Lymphokine-activated killer t-cell-originated protein kinase", "Lysine demethylase", "Lysine--tRNA ligase", "Lysine-specific demethylase", "Lysine-specific demethylase 3B", "Lysine-specific histone demethylase 1A", "Lysine-specific histone demethylase 1B", "Lysophosphatidic acid phosphatase type 6", "Lysophosphatidylcholine acyltransferase 1", "Lysophospholipid acyltransferase 5", "Lysophospholipid acyltransferase 7", "Lysosomal Pro-X carboxypeptidase", "Lysosomal acid lipase/cholesteryl ester hydrolase", "Lysosomal acid phosphatase", "Lysosomal alpha-glucosidase", "Lysosomal protective protein", "Lysosomal thioesterase PPT2", "Lysosome membrane protein 2", "Lysosome-associated membrane glycoprotein 1", "M-phase inducer phosphatase 3", "MAGUK p55 subfamily member 6", "MAPK family", "MCU family", "MMS19 nucleotide excision repair protein homolog", "Major facilitator superfamily domain-containing protein 3", "Major histocompatibility complex antigen", "Malate dehydrogenase, cytoplasmic", "Malate dehydrogenase, mitochondrial", "Mannose-6-phosphate isomerase", "Mediator of RNA polymerase II transcription subunit 21", "Mediator of RNA polymerase II transcription subunit 25", "Medium-chain specific acyl-CoA dehydrogenase, mitochondrial", "Melanoma inhibitory activity protein 2", "Melanoma-associated antigen D2", "Membralin", "Membrane trafficking regulatory protein", "Membrane-associated progesterone receptor component 1", "Membrane-associated progesterone receptor component 2", "Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase", "Metalloprotease", "Metastasis-associated protein MTA1", "Metastasis-associated protein MTA2", "Methyl-CpG-binding domain", "Methyl-CpG-binding protein 2", "Methyl-lysine/arginine binding protein", "Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial", "Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial", "Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial", "Methylosome subunit pICln", "Methyltransferase", "Mevalonate kinase", "Mevalonate kinase subfamily", "Microsomal glutathione S-transferase 2", "Microsomal glutathione S-transferase 3", "Microtubule binding motor protein", "Microtubule family cytoskeletal protein", "Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5", "Microtubule-associated protein 1B", "Microtubule-associated protein 1S", "Microtubule-associated protein RP/EB family member 1", "Microtubule-associated protein RP/EB family member 2", "Minor histocompatibility antigen H13", "Miscellaneous SLC25 mitochondrial transporters", "Mitochondrial 2-oxoglutarate/malate carrier protein", "Mitochondrial Rho GTPase 1", "Mitochondrial Rho GTPase 2", "Mitochondrial amino acid transporter subfamily", "Mitochondrial cardiolipin hydrolase", "Mitochondrial carnitine/acylcarnitine carrier protein", "Mitochondrial carrier homolog 1", "Mitochondrial carrier homolog 2", "Mitochondrial coenzyme A transporter SLC25A42", "Mitochondrial di- and tri-carboxylic acid transporter subfamily", "Mitochondrial dicarboxylate carrier", "Mitochondrial folate transporter/carrier", "Mitochondrial import receptor subunit TOM20 homolog", "Mitochondrial import receptor subunit TOM40 homolog", "Mitochondrial inner membrane protein OXA1L", "Mitochondrial intermediate peptidase", "Mitochondrial nucleotide transporter subfamily", "Mitochondrial ornithine transporter 1", "Mitochondrial phosphate transporters", "Mitochondrial proton/calcium exchanger protein", "Mitochondrial pyruvate carrier 2", "Mitochondrial thiamine pyrophosphate carrier", "Mitochondrial-processing peptidase subunit alpha", "Mitochondrial-processing peptidase subunit beta", "Mitofusin-2", "Mitogen-activated protein kinase 1", "Mitotic checkpoint protein BUB3", "Mitotic checkpoint serine/threonine-protein kinase bub1 beta", "Moesin", "Molybdate-anion transporter", "Monoacylglycerol lipase ABHD12", "Monoacylglycerol lipase ABHD6", "Monocarboxylate transporter 1", "Monofunctional C1-tetrahydrofolate synthase, mitochondrial", "Mortality factor 4-like protein 1", "Mortality factor 4-like protein 2", "Mpv17-like protein 2", "Multidrug resistance protein 1", "Multifunctional protein ADE2", "Mutase", "Myb-binding protein 1A", "Myosin light polypeptide 6", "Myosin phosphatase Rho-interacting protein", "Myotubularin-related protein 2", "Myotubularin-related protein 6", "N-acetylgalactosaminyltransferase 7", "N-acetylglucosamine-6-sulfatase", "N-acylneuraminate cytidylyltransferase", "N-alpha-acetyltransferase 15, NatA auxiliary subunit", "N-alpha-acetyltransferase 25, NatB auxiliary subunit", "N-alpha-acetyltransferase 50", "N-terminal Xaa-Pro-Lys N-methyltransferase 1", "NAD(P) transhydrogenase, mitochondrial", "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial", "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5", "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial", "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4", "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial", "NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial", "NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial", "NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial", "NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial", "NADP-dependent malic enzyme", "NAK family", "NEDD8-activating enzyme E1 catalytic subunit", "NEDD8-activating enzyme E1 regulatory subunit", "NEK family", "NF-kappa-B-repressing factor", "NSFL1 cofactor p47", "Na+/K+-ATPases", "Nardilysin", "Neuferricin", "Neurolysin, mitochondrial", "Neutral alpha-glucosidase AB", "Neutral amino acid transporter B(0)", "Nibrin", "Nicotinamide phosphoribosyltransferase", "Nipped-B-like protein", "Non-POU domain-containing octamer-binding protein", "Non-histone chromosomal protein HMG-17", "Non-motor actin binding protein", "Non-motor microtubule binding protein", "Non-protein kinase", "Nuclear RNA export factor 1", "Nuclear cap-binding protein subunit 1", "Nuclear migration protein nudC", "Nuclear pore complex protein Nup107", "Nuclear pore complex protein Nup153", "Nuclear pore complex protein Nup160", "Nuclear pore complex protein Nup214", "Nuclear pore complex protein Nup85", "Nuclear pore complex protein Nup88", "Nuclear pore complex protein Nup93", "Nuclear pore complex protein Nup98-Nup96", "Nuclear pore glycoprotein p62", "Nuclear pore membrane glycoprotein 210", "Nuclear receptor coactivator 5", "Nuclease", "Nucleic acid binding", "Nucleobindin-1", "Nucleobindin-2", "Nucleolar MIF4G domain-containing protein 1", "Nucleolar complex protein 4 homolog", "Nucleolar protein 14", "Nucleolar protein 56", "Nucleolar protein 58", "Nucleolar protein 6", "Nucleolin", "Nucleophosmin", "Nucleoporin Nup37", "Nucleoporin SEH1", "Nucleoporin p54", "Nucleoside diphosphate kinase 6", "Nucleoside diphosphate kinase A", "Nucleoside kinase", "Nucleosome assembly protein 1-like 1", "Nucleosome assembly protein 1-like 4", "Nucleotide kinase", "Nucleotide phosphatase", "Nucleotidyltransferase", "NudC domain-containing protein 2", "OCIA domain-containing protein 1", "Obg-like ATPase 1", "Occludin", "Ornithine aminotransferase, mitochondrial", "Other 7TM proteins", "Other group", "Other small molecule kinase", "Oxidase", "Oxidoreductase", "Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial", "Oxygenase", "P-type ATPases", "P53-like transcription factor", "PAKA subfamily", "PC4 and SFRS1-interacting protein", "PDHK family", "PDZ and LIM domain protein 1", "PDZ and LIM domain protein 3", "PDZ and LIM domain protein 5", "PDZ and LIM domain protein 7", "PEK family", "PH-interacting protein", "PHD finger protein 14", "PHD finger protein 6", "PIKK family", "PKC delta subfamily", "PKC family", "PKN family", "PLK family", "Paired amphipathic helix protein Sin3a", "Palmitoyl-protein thioesterase 1", "Pantothenate kinase 4", "Paraspeckle component 1", "Pentatricopeptide repeat-containing protein 1, mitochondrial", "Peptidase M20 domain-containing protein 2", "Peptidyl-prolyl cis-trans isomerase FKBP1A", "Peptidyl-prolyl cis-trans isomerase FKBP4", "Peptidyl-prolyl cis-trans isomerase FKBP5", "Perilipin-3", "Periodic tryptophan protein 1 homolog", "Peripheral plasma membrane protein cask", "Peroxidase", "Peroxiredoxin-2", "Peroxiredoxin-4", "Peroxiredoxin-6", "Peroxisomal NADH pyrophosphatase NUDT12", "Peroxisomal acyl-coenzyme A oxidase 1", "Peroxisomal acyl-coenzyme A oxidase 3", "Peroxisomal biogenesis factor 19", "Peroxisomal membrane protein 2", "Peroxisomal membrane protein PEX14", "Peroxisomal membrane protein PMP34", "Peroxisomal trans-2-enoyl-CoA reductase", "Pescadillo homolog", "Phenylalanine--tRNA ligase beta subunit", "Phosphatase", "Phosphatase activator", "Phosphatase inhibitor", "Phosphatase modulator", "Phosphate carrier protein, mitochondrial", "Phosphatidylethanolamine-binding protein 1", "Phosphatidylinositol 4-phosphate 3-kinase c2 domain-containing subunit alpha", "Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma", "Phosphatidylinositol transfer protein beta isoform", "Phosphatidylinositol-binding clathrin assembly protein", "Phosphatidylserine synthase 1", "Phosphodiesterase", "Phosphoenolpyruvate carboxykinase [GTP] family", "Phosphoenolpyruvate carboxykinase [gtp], mitochondrial", "Phosphofructokinase type A (PFKA) family", "Phosphoglycerate kinase 1", "Phosphoglycerate kinase family", "Phosphoinositide 3-kinase (PI3K) family", "Phosphoinositide 3-kinase regulatory subunit 4", "Phospholipase", "Phospholipase A-2-activating protein", "Phosphoribosyl pyrophosphate synthase-associated protein 1", "Phosphoribosyl pyrophosphate synthase-associated protein 2", "Phosphorylase", "Phosphorylase b kinase regulatory chain family", "Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform", "Pirin", "Plasminogen activator inhibitor 1 RNA-binding protein", "Plastin-3", "Plectin", "Pogo transposable element with ZNF domain", "Poly(A) RNA polymerase, mitochondrial", "Poly(A) polymerase alpha", "Poly(A)-specific ribonuclease PARN", "Poly(rC)-binding protein 1", "Poly(rC)-binding protein 2", "Polycomb protein SUZ12", "Polyglutamine-binding protein 1", "Polymerase", "Polymerase delta-interacting protein 3", "Polypeptide N-acetylgalactosaminyltransferase 1", "Polypeptide N-acetylgalactosaminyltransferase 2", "Polyribonucleotide nucleotidyltransferase 1, mitochondrial", "Porphobilinogen deaminase", "Pre-mRNA-processing factor 17", "Pre-mRNA-processing factor 39", "Pre-mRNA-processing factor 6", "Pre-mRNA-processing-splicing factor 8", "Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15", "Pre-mRNA-splicing factor RBM22", "Pre-mRNA-splicing factor SYF1", "Prefoldin subunit 2", "Prefoldin subunit 3", "Prefoldin subunit 5", "Presequence protease, mitochondrial", "Primase", "Probable 18S rRNA (guanine-N(7))-methyltransferase", "Probable ATP-dependent RNA helicase DHX37", "Probable E3 ubiquitin-protein ligase makorin-2", "Probable RNA-binding protein 19", "Probable global transcription activator SNF2L1", "Probable leucine--tRNA ligase, mitochondrial", "Probable ribosome biogenesis protein RLP24", "Probable serine carboxypeptidase CPVL", "Probable tRNA N6-adenosine threonylcarbamoyltransferase", "Probable tRNA pseudouridine synthase 1", "Procollagen galactosyltransferase 1", "Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1", "Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2", "Programmed cell death 6-interacting protein", "Programmed cell death protein 4", "Programmed cell death protein 5", "Prolactin regulatory element-binding protein", "Proliferating cell nuclear antigen", "Prolyl 3-hydroxylase 1", "Prolyl endopeptidase", "Propionyl-CoA carboxylase alpha chain, mitochondrial", "Prostaglandin E synthase 2", "Prostaglandin E synthase 3", "Prostaglandin reductase 1", "Prostaglandin reductase 2", "Prostaglandin reductase 3", "Protease", "Protease inhibitor", "Proteasome inhibitor PI31 subunit", "Protein AATF", "Protein BUD31 homolog", "Protein DDI1 homolog 2", "Protein ERGIC-53", "Protein FRG1", "Protein LSM14 homolog B", "Protein NDRG3", "Protein PAT1 homolog 1", "Protein PRRC2A", "Protein PRRC2C", "Protein RRP5 homolog", "Protein Red", "Protein S100-A10", "Protein S100-A11", "Protein S100-A13", "Protein SCO1 homolog, mitochondrial", "Protein SCO2 homolog, mitochondrial", "Protein SET", "Protein SYS1 homolog", "Protein Wiz", "Protein arginine N-methyltransferase 1", "Protein arginine N-methyltransferase 3", "Protein arginine N-methyltransferase 5", "Protein arginine methyltransferase", "Protein farnesyltransferase subunit beta", "Protein gpr107", "Protein kinase", "Protein kinase C and casein kinase substrate in neurons protein 2", "Protein kinase c delta type", "Protein methyltransferase", "Protein pelota homolog", "Protein phosphatase", "Protein phosphatase 1G", "Protein phosphatase methylesterase 1", "Protein polybromo-1", "Protein quaking", "Protein spinster homolog 1", "Protein transport protein Sec23A", "Protein transport protein Sec24A", "Protein transport protein Sec24B", "Protein transport protein Sec24C", "Protein transport protein Sec24D", "Protein transport protein Sec31A", "Protein transport protein Sec61 subunit alpha isoform 1", "Protein tweety homolog 3", "Protein unc-119 homolog B", "Protein-L-isoaspartate(D-aspartate) O-methyltransferase", "Protein/nucleic acid deglycase DJ-1", "Pterin-4-alpha-carbinolamine dehydratase", "Purine nucleoside phosphorylase", "Puromycin-sensitive aminopeptidase", "Putative oxidoreductase GLYR1", "Putative phospholipase B-like 2", "Pyridoxal kinase", "Pyridoxine kinase family", "Pyrophosphatase", "Pyruvate carboxylase, mitochondrial", "Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial", "Pyruvate kinase pkm", "RIO family", "RIO2 subfamily", "RNA 3'-terminal phosphate cyclase-like protein", "RNA binding protein", "RNA helicase", "RNA-binding motif protein, X chromosome", "RNA-binding protein 12", "RNA-binding protein 12B", "RNA-binding protein 14", "RNA-binding protein 26", "RNA-binding protein 27", "RNA-binding protein 3", "RNA-binding protein 4", "RNA-binding protein EWS", "RNA-binding protein FUS", "ROCK subfamily", "RSK family", "RSK subfamily", "Rab GDP dissociation inhibitor alpha", "Rab GDP dissociation inhibitor beta", "Rab GTPase-activating protein 1", "Rab proteins geranylgeranyltransferase component A 1", "Rab3 GTPase-activating protein non-catalytic subunit", "Rac GTPase-activating protein 1", "Rac-beta serine/threonine-protein kinase", "Radixin", "RalBP1-associated Eps domain-containing protein 1", "Ran GTPase-activating protein 1", "Ran-binding protein 3", "Ran-binding protein 9", "Ran-specific GTPase-activating protein", "Rap guanine nucleotide exchange factor 2", "Ras GTPase-activating protein-binding protein 1", "Ras GTPase-activating protein-binding protein 2", "Ras GTPase-activating-like protein IQGAP1", "Ras-related C3 botulinum toxin substrate 1", "Ras-related protein Ral-A", "Ras-related protein Rap-2b", "Reader", "Receptor", "Receptor expression-enhancing protein 4", "Receptor expression-enhancing protein 5", "Reductase", "Regulation of nuclear pre-mRNA domain-containing protein 1A", "Regulation of nuclear pre-mRNA domain-containing protein 1B", "Regulation of nuclear pre-mRNA domain-containing protein 2", "Regulator of nonsense transcripts 1", "Rel homology transcription factor", "Remodeling and spacing factor 1", "Renin receptor", "Replication factor C subunit 2", "Replication factor C subunit 3", "Replication factor C subunit 4", "Replication factor C subunit 5", "Replication protein A 70 kDa DNA-binding subunit", "Reticulocalbin-1", "Reticulocalbin-2", "Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta", "Retinoblastoma-associated protein", "Retinoid-inducible serine carboxypeptidase", "Retinol dehydrogenase 11", "Rho GDP-dissociation inhibitor 1", "Rho-associated protein kinase 1", "Rho-associated protein kinase 2", "Ribonuclease H2 subunit A", "Ribonuclease P protein subunit p30", "Ribonuclease inhibitor", "Ribonucleoprotein", "Ribonucleoprotein PTB-binding 1", "Ribonucleoside-diphosphate reductase large subunit", "Ribonucleoside-diphosphate reductase subunit M2", "Ribose-phosphate pyrophosphokinase 1", "Ribosomal L1 domain-containing protein 1", "Ribosomal RNA small subunit methyltransferase NEP1", "Ribosomal protein", "Ribosomal protein s6 kinase alpha-1", "Ribosomal protein s6 kinase alpha-3", "Ribosome biogenesis protein BOP1", "Ribosome biogenesis protein BRX1 homolog", "Ribosome biogenesis regulatory protein homolog", "Ribosome maturation protein SBDS", "Ribosome production factor 2 homolog", "S-adenosylhomocysteine hydrolase-like protein 1", "S-adenosylmethionine mitochondrial carrier protein", "S-adenosylmethionine synthase isoform type-2", "S-formylglutathione hydrolase", "S-methyl-5'-thioadenosine phosphorylase", "S-phase kinase-associated protein 1", "SAP30-binding protein", "SEC23-interacting protein", "SET domain", "SLC superfamily of solute carriers", "SLC1 family of amino acid transporters", "SLC12 family of cation-coupled chloride transporters", "SLC16 family of monocarboxylate transporters", "SLC25 family of mitochondrial transporters", "SLC27 family of fatty acid transporters", "SLC28 and SLC29 families of nucleoside transporters", "SLC29 family", "SLC3 and SLC7 families of heteromeric amino acid transporters (HATs)", "SLC3 family", "SLC30 zinc transporter family", "SLC35 family of nucleotide sugar transporters", "SLC38 family of sodium-dependent neutral amino acid transporters", "SLC4 family of bicarbonate transporters", "SLC54 Mitochondrial pyruvate carriers", "SLC55 Mitochondrial cation/proton exchangers", "SLC56 Sideroflexins", "SLC61 Molybdate transporter family", "SLC63 Sphingosine-phosphate transporters", "SLK subfamily", "SNARE protein", "SNW domain-containing protein 1", "SRPK family", "STAM-binding protein", "STE group", "STE20 family", "STE7 family", "SUMO-activating enzyme subunit 1", "SUMO-activating enzyme subunit 2", "SUN domain-containing protein 1", "SURP and G-patch domain-containing protein 1", "SURP and G-patch domain-containing protein 2", "SWI/SNF complex subunit SMARCC1", "SWI/SNF complex subunit SMARCC2", "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1", "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5", "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1", "Sarcoplasmic/endoplasmic reticulum calcium ATPase 2", "Scavenger receptor class B member 1", "Sec1 family domain-containing protein 1", "Secretory carrier-associated membrane protein 2", "Secretory carrier-associated membrane protein 3", "Selenide, water dikinase 1", "Sentrin-specific protease 3", "Septin-2", "Septin-7", "Septin-9", "Serine hydroxymethyltransferase, cytosolic", "Serine hydroxymethyltransferase, mitochondrial", "Serine palmitoyltransferase 1", "Serine palmitoyltransferase 2", "Serine protease", "Serine protease inhibitor", "Serine--tRNA ligase, cytoplasmic", "Serine--tRNA ligase, mitochondrial", "Serine/arginine repetitive matrix protein 1", "Serine/arginine-rich splicing factor 1", "Serine/arginine-rich splicing factor 10", "Serine/arginine-rich splicing factor 11", "Serine/arginine-rich splicing factor 2", "Serine/arginine-rich splicing factor 3", "Serine/arginine-rich splicing factor 5", "Serine/arginine-rich splicing factor 6", "Serine/arginine-rich splicing factor 7", "Serine/arginine-rich splicing factor 9", "Serine/threonine-protein kinase mtor", "Serine/threonine-protein kinase n2", "Serine/threonine-protein kinase nek9", "Serine/threonine-protein kinase osr1", "Serine/threonine-protein kinase pak 1", "Serine/threonine-protein kinase pak 2", "Serine/threonine-protein kinase plk1", "Serine/threonine-protein kinase prp4 homolog", "Serine/threonine-protein kinase rio2", "Serine/threonine-protein kinase vrk1", "Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform", "Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform", "Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform", "Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform", "Serine/threonine-protein phosphatase 2A activator", "Serine/threonine-protein phosphatase 4 regulatory subunit 1", "Serine/threonine-protein phosphatase PP1-alpha catalytic subunit", "Serine/threonine-protein phosphatase PP1-beta catalytic subunit", "Serpin B6", "Serpin H1", "Set1/Ash2 histone methyltransferase complex subunit ASH2", "Sex comb on midleg-like protein 2", "Sialic acid synthase", "Sideroflexin-1", "Sideroflexin-2", "Sigma intracellular receptor 2", "Signal peptidase complex catalytic subunit SEC11A", "Signal peptidase complex subunit 2", "Signal peptide peptidase-like 2A", "Signal recognition particle 14 kDa protein", "Signal recognition particle 54 kDa protein", "Signal recognition particle 9 kDa protein", "Signal recognition particle receptor subunit alpha", "Signal recognition particle subunit SRP68", "Signal transducer and activator of transcription 1-alpha/beta", "Signal transducer and activator of transcription 3", "Signaling", "Single-stranded DNA-binding protein, mitochondrial", "Sister chromatid cohesion protein PDS5 homolog A", "Sister chromatid cohesion protein PDS5 homolog B", "Small GTPase", "Small nuclear ribonucleoprotein E", "Small nuclear ribonucleoprotein Sm D1", "Small nuclear ribonucleoprotein Sm D2", "Small nuclear ribonucleoprotein Sm D3", "Sodium bicarbonate cotransporter 3", "Sodium-coupled neutral amino acid transporter 2", "Sodium-dependent HCO3- transporters", "Sodium/potassium-transporting ATPase subunit alpha-1", "Sodium/potassium-transporting ATPase subunit beta-1", "Sodium/potassium-transporting ATPase subunit beta-3", "Solute carrier family 12 member 2", "Solute carrier family 12 member 9", "Solute carrier family 25 member 44", "Solute carrier family 35 member F1", "Solute carrier family 35 member F2", "Sortilin", "Sorting nexin-1", "Sorting nexin-2", "Spermatid perinuclear RNA-binding protein", "Spermidine synthase", "Splicing factor 1", "Splicing factor 3A subunit 1", "Splicing factor 3A subunit 2", "Splicing factor 3A subunit 3", "Splicing factor 3B subunit 1", "Splicing factor 3B subunit 3", "Splicing factor 45", "Splicing factor, proline- and glutamine-rich", "Splicing factor, suppressor of white-apricot homolog", "Splicing regulatory glutamine/lysine-rich protein 1", "Squalene monooxygenase", "Squamous cell carcinoma antigen recognized by T-cells 3", "Src substrate cortactin", "Srsf protein kinase 1", "Staphylococcal nuclease domain-containing protein 1", "Ste20-like serine/threonine-protein kinase", "Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating", "Stomatin-like protein 2, mitochondrial", "Storage", "Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial", "Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial", "Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial", "Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial", "Succinate-semialdehyde dehydrogenase, mitochondrial", "Sulfhydryl oxidase 2", "Superoxide dismutase [Mn], mitochondrial", "Surfeit locus protein 4", "Surfeit locus protein 6", "Survival motor neuron protein", "Synaptic functional regulator FMR1", "Synaptogyrin-2", "Syntaxin-18", "Syntaxin-4", "Syntaxin-5", "Syntaxin-7", "Syntaxin-8", "Syntaxin-binding protein 3", "Syntenin-1", "System A-like transporters", "T-complex protein 1 subunit alpha", "T-complex protein 1 subunit beta", "T-complex protein 1 subunit delta", "T-complex protein 1 subunit epsilon", "T-complex protein 1 subunit eta", "T-complex protein 1 subunit gamma", "T-complex protein 1 subunit theta", "T-complex protein 1 subunit zeta", "TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L", "TATA-binding protein-associated factor 2N", "TBC1 domain family member 13", "TBC1 domain family member 15", "TBC1 domain family member 4", "TBC1 domain family member 9B", "THO complex subunit 1", "THO complex subunit 2", "THO complex subunit 3", "TK group", "TNF receptor-associated factor 2", "TOPK family", "TRIO family", "TTK family", "Target of EGR1 protein 1", "Targeting protein for Xklp2", "Terminal uridylyltransferase 4", "Thimet oligopeptidase", "Thioredoxin domain-containing protein 12", "Thioredoxin domain-containing protein 17", "Thioredoxin domain-containing protein 9", "Thioredoxin reductase 1, cytoplasmic", "Thioredoxin-dependent peroxide reductase, mitochondrial", "Threonine--tRNA ligase, cytoplasmic", "Threonine--tRNA ligase, mitochondrial", "Thymidine kinase family", "Thymidine kinase, cytosolic", "Thymidylate kinase", "Thymidylate kinase family", "Thymidylate synthase", "Thyroid adenoma-associated protein", "Thyroid hormone receptor-associated protein 3", "Tight junction", "Tight junction protein ZO-1", "Trafficking protein particle complex subunit 4", "Transaminase", "Transcription activator BRG1", "Transcription cofactor", "Transcription elongation factor A protein 1", "Transcription elongation factor SPT6", "Transcription elongation regulator 1", "Transcription factor", "Transcription factor p65", "Transcriptional activator protein Pur-alpha", "Transcriptional repressor p66-alpha", "Transferase", "Transferrin receptor protein 1", "Transformer-2 protein homolog alpha", "Transformer-2 protein homolog beta", "Transgelin-2", "Transketolase", "Translation elongation factor", "Translation factor", "Translation factor GUF1, mitochondrial", "Translation initiation factor", "Translation release factor", "Translationally-controlled tumor protein", "Translocation protein SEC63 homolog", "Translocon-associated protein subunit alpha", "Transmembrane 9 superfamily member 3", "Transmembrane 9 superfamily member 4", "Transmembrane emp24 domain-containing protein 10", "Transmembrane emp24 domain-containing protein 2", "Transmembrane emp24 domain-containing protein 5", "Transmembrane emp24 domain-containing protein 7", "Transmembrane emp24 domain-containing protein 9", "Transporter", "Transportin-1", "Transportin-3", "Tricarboxylate transport protein, mitochondrial", "Trifunctional enzyme subunit alpha, mitochondrial", "Trifunctional enzyme subunit beta, mitochondrial", "Trifunctional purine biosynthetic protein adenosine-3", "Triosephosphate isomerase", "Tripeptidyl-peptidase 1", "Tripeptidyl-peptidase 2", "Triple functional domain protein", "Tropomodulin-3", "Tropomyosin alpha-1 chain", "Tropomyosin alpha-3 chain", "Tropomyosin alpha-4 chain", "Tryptophan--tRNA ligase, cytoplasmic", "Tubulin", "Tubulin beta chain", "Tubulin beta-2A chain", "Tubulin beta-2B chain", "Tubulin beta-4A chain", "Tubulin beta-4B chain", "Tubulin beta-6 chain", "Tubulin-folding cofactor B", "Tubulin-specific chaperone A", "Tubulin-specific chaperone D", "Tubulin-specific chaperone E", "Tudor and KH domain-containing protein", "Tudor domain", "Tumor susceptibility gene 101 protein", "Twinfilin-1", "Twinfilin-2", "Tyrosine--tRNA ligase, cytoplasmic", "Tyrosine--tRNA ligase, mitochondrial", "Tyrosine-protein kinase csk", "U1 small nuclear ribonucleoprotein 70 kDa", "U1 small nuclear ribonucleoprotein A", "U2 small nuclear ribonucleoprotein A'", "U2 snRNP-associated SURP motif-containing protein", "U3 small nucleolar RNA-associated protein 14 homolog A", "U3 small nucleolar RNA-associated protein 6 homolog", "U3 small nucleolar ribonucleoprotein protein IMP4", "U3 small nucleolar ribonucleoprotein protein MPP10", "U4/U6 small nuclear ribonucleoprotein Prp3", "U4/U6 small nuclear ribonucleoprotein Prp31", "U4/U6 small nuclear ribonucleoprotein Prp4", "U4/U6.U5 tri-snRNP-associated protein 1", "U4/U6.U5 tri-snRNP-associated protein 2", "U6 snRNA-associated Sm-like protein LSm2", "U6 snRNA-associated Sm-like protein LSm6", "U6 snRNA-associated Sm-like protein LSm7", "UDP-glucose:glycoprotein glucosyltransferase 1", "UMP-CMP kinase", "UV excision repair protein RAD23 homolog A", "UV excision repair protein RAD23 homolog B", "Ubiquinone biosynthesis O-methyltransferase, mitochondrial", "Ubiquitin carboxyl-terminal hydrolase 10", "Ubiquitin carboxyl-terminal hydrolase 11", "Ubiquitin carboxyl-terminal hydrolase 14", "Ubiquitin carboxyl-terminal hydrolase 28", "Ubiquitin carboxyl-terminal hydrolase 34", "Ubiquitin carboxyl-terminal hydrolase 47", "Ubiquitin carboxyl-terminal hydrolase 5", "Ubiquitin carboxyl-terminal hydrolase 7", "Ubiquitin carboxyl-terminal hydrolase 8", "Ubiquitin carboxyl-terminal hydrolase isozyme L5", "Ubiquitin conjugation factor E4 A", "Ubiquitin thioesterase OTUB1", "Ubiquitin-conjugating enzyme E2 L3", "Ubiquitin-like modifier-activating enzyme 1", "Ubiquitin-like modifier-activating enzyme 6", "Ubiquitin-like-conjugating enzyme ATG3", "Ubiquitin-protein ligase", "Unclassified protein", "Unconventional myosin-Ib", "Unconventional myosin-Ic", "Unconventional myosin-Id", "Unconventional myosin-VI", "Uridine kinase family", "Uridine-cytidine kinase 2", "V-type ATPase", "V-type proton ATPase 116 kDa subunit a isoform 1", "V-type proton ATPase 116 kDa subunit a isoform 2", "V-type proton ATPase catalytic subunit A", "V-type proton ATPase subunit B, brain isoform", "V-type proton ATPase subunit C 1", "V-type proton ATPase subunit D", "V-type proton ATPase subunit G 1", "V-type proton ATPase subunit H", "V-type proton ATPase subunit d 1", "VPS15 family", "VRK family", "Vacuolar protein sorting-associated protein 18 homolog", "Vacuolar protein sorting-associated protein 26A", "Vacuolar protein sorting-associated protein 29", "Vacuolar protein sorting-associated protein 33B", "Vacuolar protein sorting-associated protein 35", "Vacuolar protein sorting-associated protein 4A", "Vacuolar protein sorting-associated protein 4B", "Vacuole membrane protein 1", "Very long-chain acyl-CoA synthetase", "Very long-chain specific acyl-CoA dehydrogenase, mitochondrial", "Very-long-chain enoyl-CoA reductase", "Vesicle coat protein", "Vesicle-associated membrane protein 7", "Vesicle-associated membrane protein-associated protein A", "Vesicle-associated membrane protein-associated protein B/C", "Vesicle-fusing ATPase", "Vesicular integral-membrane protein VIP36", "Vitamin K epoxide reductase complex subunit 1-like protein 1", "WD repeat and HMG-box DNA-binding protein 1", "WD repeat-containing protein 1", "WEE family", "Writer", "X-ray repair cross-complementing protein 5", "X-ray repair cross-complementing protein 6", "Xaa-Pro dipeptidase", "YLP motif-containing protein 1", "Zinc finger CCCH domain-containing protein 11A", "Zinc finger CCCH domain-containing protein 15", "Zinc finger CCHC domain-containing protein 8", "Zinc finger MYM-type protein 4", "Zinc finger RNA-binding protein", "Zinc finger transcription factor", "Zinc transporter 5", "Zyxin", "[pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial", "[pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial", "c-Myc-binding protein", "eIF-2-alpha kinase activator GCN1", "eukaryotic two domain clade \"e\" sub-subfamily", "m7GpppX diphosphatase", "mRNA export factor", "mRNA polyadenylation factor", "mRNA processing factor", "mRNA splicing factor", "pre-mRNA 3' end processing protein WDR33", "rRNA 2'-O-methyltransferase fibrillarin", "tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6", "tRNA (cytosine(34)-C(5))-methyltransferase", "tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4", "tRNA pseudouridine synthase A"], "available_proteins": ["AARS", "AARS2", "AASDHPPT", "AATF", "ABCB1", "ABCB7", "ABCD3", "ABCF1", "ABCF2", "ABCF3", "ABHD12", "ABHD6", "ABI1", "ACAA2", "ACAD9", "ACADM", "ACADVL", "ACAT1", "ACAT2", "ACLY", "ACO2", "ACOT7", "ACOT9", "ACOX1", "ACOX3", "ACP2", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTR1A", "ACTR2", "ACTR3", "ADAR", "ADD1", "ADD3", "ADH5", "ADI1", "ADK", "ADPGK", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGL", "AHCY", "AHCYL1", "AIFM1", "AIMP1", "AIP", "AK1", "AK2", "AK3", "AKAP1", "AKR1A1", "AKR1B1", "AKR7A2", "AKT2", "ALDH16A1", "ALDH18A1", "ALDH1B1", "ALDH2", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALG1", "ALG12", "ANAPC1", "ANAPC10", "ANP32A", "ANP32B", "AP1B1", "AP1G1", "AP1M1", "AP1S2", "AP2A1", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "APEH", "APLP2", "APOL2", "APP", "ARCN1", "ARFIP1", "ARFIP2", "ARHGDIA", "ARID3B", "ARIH1", "ARIH2", "ARPC1A", "ARPC3", "ARPC4", "ARSA", "ASAH1", "ASH2L", "ASNA1", "ASNS", "ASRGL1", "ATAD3A", "ATAD3B", "ATG3", "ATIC", "ATL2", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2C1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP6", "ATP6AP2", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1D", "ATP6V1G1", "ATP6V1H", "ATP7B", "ATPAF1", "ATPIF1", "ATXN2L", "AUP1", "AURKA", "BAG6", "BAIAP2", "BCAP31", "BCLAF1", "BLMH", "BLVRA", "BOP1", "BPNT1", "BRD2", "BRIX1", "BUB1B", "BUB3", "BUD23", "BUD31", "BZW1", "BZW2", "CAB39", "CACYBP", "CAD", "CALM3", "CALR", "CALU", "CAMK1", "CAMK2G", "CAND1", "CAND2", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPRIN1", "CAPZA1", "CAPZA2", "CAPZB", "CARM1", "CARS", "CASK", "CBL", "CBX1", "CBX2", "CBX3", "CBX5", "CCAR1", "CCAR2", "CCNB1", "CCNB2", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CDC20", "CDC25C", "CDC37", "CDC40", "CDC42", "CDK1", "CDK2", "CDK4", "CDK5", "CDK6", "CDKN2AIP", "CDX2", "CEBPZ", "CEPT1", "CETN2", "CFAP20", "CHAF1A", "CHAF1B", "CHERP", "CHKA", "CHM", "CHMP7", "CHORDC1", "CHRAC1", "CHST14", "CHUK", "CIRBP", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLASP2", "CLCC1", "CLCN3", "CLCN7", "CLGN", "CLIC1", "CLIC4", "CLIP1", "CLNS1A", "CLPTM1", "CLPTM1L", "CLPX", "CLTC", "CLUH", "CMAS", "CMPK1", "CNDP2", "CNN2", "CNN3", "CNOT1", "CNOT2", "CNOT3", "CNOT4", "CNOT7", "CNP", "COIL", "COL4A3BP", "COLEC12", "COLGALT1", "COMT", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS3", "COPS5", "COPS6", "COPS8", "COPZ1", "COQ3", "CORO1A", "CORO1C", "CORO7", "COTL1", "COX2", "COX5A", "COX7A2", "CPOX", "CPSF1", "CPSF3", "CPSF6", "CPSF7", "CPT2", "CPVL", "CRNKL1", "CRTAP", "CS", "CSE1L", "CSGALNACT2", "CSK", "CSNK1A1", "CSNK2A1", "CSNK2A2", "CSNK2B", "CSTB", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTH", "CTNNA1", "CTNND1", "CTPS1", "CTPS2", "CTSA", "CTSB", "CTSC", "CTTN", "CUL1", "CUL2", "CUL4B", "CUL5", "CYB5B", "CYB5D2", "CYFIP1", "CYP51A1", "DAP3", "DARS", "DARS2", "DBN1", "DBNL", "DCPS", "DCTN1", "DCTN2", "DDB1", "DDI2", "DDOST", "DDT", "DENR", "DERL1", "DHCR24", "DHCR7", "DHFR", "DHX15", "DHX29", "DHX37", "DHX8", "DHX9", "DIDO1", "DIEXF", "DIS3", "DLD", "DLST", "DNASE2", "DNM1L", "DNM2", "DNMT1", "DOCK7", "DPH5", "DPM1", "DPP3", "DPP9", "DPYSL2", "DPYSL5", "DSC1", "DSC3", "DSG2", "DSP", "DST", "DTYMK", "DUT", "DYNC1H1", "DYNC1LI1", "DYNC1LI2", "DYNC2H1", "DYNLL1", "ECE1", "ECH1", "ECHS1", "ECI1", "ECI2", "EDC4", "EEF1A2", "EEF1B2", "EEF1D", "EEF2", "EFHD1", "EFL1", "EFTUD2", "EHD1", "EHD4", "EIF2A", "EIF2AK2", "EIF2D", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3H", "EIF3I", "EIF3J", "EIF3L", "EIF4B", "EIF4E", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "ELMO2", "ELMOD2", "ELOB", "ELOC", "ELP1", "ELP3", "EMC2", "EMG1", "ENO1", "ENO2", "EPHA7", "EPHX2", "EPPK1", "EPRS", "EPS15", "EPS15L1", "ERAL1", "ERAP1", "ERH", "ERI1", "ERMP1", "ERO1A", "ERP29", "ESD", "ETF1", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXO1", "EXOC3", "EXOC5", "EXOC7", "EXOSC2", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "EZR", "FAHD1", "FARSB", "FASN", "FBL", "FDPS", "FECH", "FEN1", "FH", "FKBP1A", "FKBP4", "FKBP5", "FMR1", "FN3KRP", "FNTB", "FOXRED1", "FRG1", "FSCN1", "FUBP1", "FUBP3", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GAK", "GALK1", "GALM", "GALNT1", "GALNT2", "GALNT7", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GCAT", "GCFC2", "GCLC", "GCLM", "GCN1", "GDI1", "GDI2", "GFPT1", "GGH", "GLB1", "GLDC", "GLRX3", "GLRX5", "GLS", "GLUD1", "GLYR1", "GM2A", "GMFB", "GMPS", "GNA13", "GNAI1", "GNAI2", "GNAI3", "GNPDA1", "GNS", "GPATCH4", "GPD2", "GPI", "GPKOW", "GPR107", "GRHPR", "GRPEL1", "GRSF1", "GSK3B", "GSPT1", "GSR", "GSS", "GTF3C3", "GTPBP1", "GUF1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACL1", "HADHA", "HADHB", "HAT1", "HBS1L", "HCCS", "HDAC2", "HDGF", "HDGFL2", "HDHD2", "HDHD5", "HEATR1", "HEXA", "HEXB", "HIBADH", "HIBCH", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLCS", "HM13", "HMBS", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMGN2", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPM", "HNRNPR", "HPRT1", "HSD17B10", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPE1", "HUWE1", "IARS", "IARS2", "IDE", "IDH3A", "IDH3B", "IDI1", "IGBP1", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IK", "ILF3", "ILKAP", "ILVBL", "IMP4", "IMPDH1", "IMPDH2", "INTS11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "ITGB1", "ITPA", "IVD", "KARS", "KCTD12", "KDELR1", "KDM1A", "KDM1B", "KDM3B", "KHDRBS1", "KHSRP", "KIF11", "KIF15", "KIF18B", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF4A", "KIF5B", "KIF7", "KIFC1", "KPNA1", "KPNA2", "KPNA3", "KPNB1", "KRR1", "LAMP1", "LAP3", "LARP1", "LARP4", "LARP4B", "LARS2", "LBR", "LDHA", "LDHB", "LETM1", "LGALS3", "LGMN", "LIG1", "LIG3", "LIMA1", "LIPA", "LLGL1", "LMAN1", "LMAN2", "LNPEP", "LONP1", "LPCAT1", "LPCAT3", "LRRC47", "LRWD1", "LSM14B", "LSM2", "LSM6", "LSM7", "LTN1", "M6PR", "MACF1", "MAGED2", "MANBA", "MAP1B", "MAP1S", "MAP2K1", "MAPK1", "MAPRE1", "MAPRE2", "MAT2A", "MBOAT7", "MCCC1", "MCCC2", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCU", "MDH1", "MDH2", "ME1", "MECP2", "MED21", "MED25", "MFN2", "MFSD3", "MFSD5", "MGST2", "MGST3", "MIA2", "MICU1", "MIPEP", "MKRN2", "MMS19", "MORF4L1", "MORF4L2", "MPC2", "MPHOSPH10", "MPI", "MPP6", "MPRIP", "MPST", "MPV17L2", "MRPL1", "MRPL11", "MRPL12", "MRPL14", "MRPL19", "MRPL21", "MRPL38", "MRPL39", "MRPL44", "MRPL47", "MRPL48", "MRPL49", "MRPL9", "MRPS11", "MRPS2", "MRPS27", "MRPS35", "MRPS5", "MRPS7", "MSH2", "MSH3", "MSH6", "MSN", "MTA1", "MTA2", "MTAP", "MTCH1", "MTCH2", "MTHFD1", "MTHFD1L", "MTHFD2", "MTMR2", "MTMR6", "MTOR", "MTPAP", "MVK", "MYBBP1A", "MYCBP", "MYL6", "MYO1B", "MYO1C", "MYO1D", "MYO6", "NAA15", "NAA25", "NAA50", "NAE1", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NARS", "NBN", "NCAPD2", "NCBP1", "NCL", "NCOA5", "NDRG3", "NDUFA10", "NDUFA4", "NDUFA5", "NDUFA9", "NDUFB4", "NDUFB5", "NDUFS1", "NDUFS2", "NDUFS6", "NDUFS7", "NEK9", "NHP2", "NIPBL", "NKRF", "NLN", "NME1", "NME6", "NMT1", "NNT", "NOC4L", "NOL6", "NOM1", "NONO", "NOP14", "NOP56", "NOP58", "NPEPPS", "NPM1", "NRDC", "NSD2", "NSDHL", "NSF", "NSFL1C", "NSUN2", "NT5C2", "NT5C3B", "NT5DC1", "NT5DC2", "NTHL1", "NTMT1", "NTPCR", "NUCB1", "NUCB2", "NUDC", "NUDCD2", "NUDT1", "NUDT12", "NUDT21", "NUDT5", "NUF2", "NUP107", "NUP153", "NUP160", "NUP210", "NUP214", "NUP37", "NUP54", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NXF1", "OAT", "OCIAD1", "OCLN", "OCRL", "OLA1", "OPA1", "OSGEP", "OTUB1", "OXA1L", "OXSR1", "P3H1", "P3H4", "PACSIN2", "PAICS", "PAK1", "PAK2", "PANK4", "PAPOLA", "PAPSS1", "PARK7", "PARN", "PATL1", "PBK", "PBRM1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCK2", "PCMT1", "PCNA", "PDCD11", "PDCD4", "PDCD5", "PDCD6IP", "PDE12", "PDE6D", "PDK1", "PDK3", "PDLIM1", "PDLIM3", "PDLIM5", "PDLIM7", "PDPR", "PDS5A", "PDS5B", "PDXK", "PEBP1", "PECR", "PELO", "PEPD", "PES1", "PEX14", "PEX19", "PFDN2", "PFDN5", "PFKL", "PFKM", "PFKP", "PGD", "PGGT1B", "PGK1", "PGLS", "PGP", "PGRMC1", "PGRMC2", "PHF14", "PHF6", "PHGDH", "PHIP", "PHKA1", "PICALM", "PIK3C2A", "PIK3R4", "PIP4K2C", "PIR", "PITPNB", "PITRM1", "PKM", "PKMYT1", "PKN2", "PLA2G15", "PLAA", "PLBD2", "PLCG1", "PLD6", "PLEC", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLS3", "PM20D2", "PMPCA", "PMPCB", "PNP", "PNPT1", "POGZ", "POLA2", "POLD2", "POLDIP3", "POLE4", "POLR1A", "POLR1B", "POLR2A", "POLR2B", "POLR2C", "POLR2G", "POLR3A", "POLR3C", "POLRMT", "PPA1", "PPA2", "PPAT", "PPM1G", "PPME1", "PPP1CA", "PPP1CB", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP4R1", "PPT1", "PPT2", "PQBP1", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX6", "PREB", "PREP", "PRIM1", "PRKAG1", "PRKCD", "PRKCSH", "PRKDC", "PRKRA", "PRMT1", "PRMT3", "PRMT5", "PRPF3", "PRPF31", "PRPF39", "PRPF4", "PRPF4B", "PRPF6", "PRPF8", "PRPS1", "PRPSAP1", "PRPSAP2", "PRRC2A", "PRRC2C", "PSIP1", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD7", "PSMD8", "PSMF1", "PSPC1", "PTCD1", "PTDSS1", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK7", "PTPA", "PURA", "PUS1", "PWP1", "PXMP2", "PYGB", "PYGL", "QARS", "QDPR", "QKI", "QSOX2", "RAB3GAP2", "RABGAP1", "RABGGTA", "RAC1", "RACGAP1", "RAD23A", "RAD23B", "RAE1", "RALA", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP9", "RANGAP1", "RAP2B", "RAPGEF2", "RAVER1", "RB1", "RBBP6", "RBM12", "RBM12B", "RBM14", "RBM17", "RBM19", "RBM22", "RBM26", "RBM27", "RBM3", "RBM4", "RBMX", "RCL1", "RCN1", "RCN2", "RDH11", "RDX", "RECQL", "REEP4", "REEP5", "RELA", "REPS1", "RFC2", "RFC3", "RFC4", "RFC5", "RHEB", "RHOT1", "RHOT2", "RIOK2", "RNASEH2A", "RNH1", "ROCK1", "ROCK2", "RPA1", "RPF2", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL18", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL38", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPN1", "RPN2", "RPP30", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15A", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RRM1", "RRM2", "RRS1", "RSF1", "RSL1D1", "RSL24D1", "S100A10", "S100A11", "S100A13", "SAE1", "SAP18", "SAP30BP", "SARS", "SARS2", "SART1", "SART3", "SBDS", "SC5D", "SCAMP2", "SCAMP3", "SCARB1", "SCARB2", "SCFD1", "SCML2", "SCO1", "SCO2", "SCPEP1", "SDCBP", "SDF4", "SDHA", "SDHB", "SDR39U1", "SEC11A", "SEC23A", "SEC23IP", "SEC24A", "SEC24B", "SEC24C", "SEC24D", "SEC31A", "SEC61A1", "SEC63", "SEH1L", "SENP3", "SEPHS1", "SEPT2", "SEPT7", "SEPT9", "SERBP1", "SERPINB6", "SERPINH1", "SET", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B3", "SFPQ", "SFSWAP", "SFXN1", "SFXN2", "SHMT1", "SHMT2", "SIN3A", "SKP1", "SLC12A2", "SLC12A9", "SLC16A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A17", "SLC25A19", "SLC25A20", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A4", "SLC25A42", "SLC25A44", "SLC25A5", "SLC25A6", "SLC27A2", "SLC27A4", "SLC29A1", "SLC30A5", "SLC35B2", "SLC35F1", "SLC35F2", "SLC38A2", "SLC3A2", "SLC4A7", "SLK", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCB1", "SMARCC1", "SMARCC2", "SMN1*", "SMYD3", "SND1", "SNRNP70", "SNRPA", "SNRPA1", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNW1", "SNX1", "SNX2", "SOD2", "SORT1", "SPAG9", "SPCS2", "SPNS1", "SPPL2A", "SPTLC1", "SPTLC2", "SQLE", "SREK1", "SRM", "SRP14", "SRP54", "SRP68", "SRP9", "SRPK1", "SRPRA", "SRRM1", "SRSF1", "SRSF10", "SRSF11", "SRSF2", "SRSF3", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSR1", "STAG2", "STAMBP", "STAT1", "STAT3", "STOM", "STOML2", "STRBP", "STT3A", "STT3B", "STX18", "STX4", "STX5", "STX7", "STX8", "STXBP3", "SUCLA2", "SUCLG2", "SUGP1", "SUGP2", "SUN1", "SUPT16H", "SUPT6H", "SURF4", "SURF6", "SUZ12", "SYNCRIP", "SYNGR2", "SYS1", "TAF15", "TAF6L", "TAGLN2", "TARS", "TARS2", "TBC1D13", "TBC1D15", "TBC1D4", "TBC1D9B", "TBCA", "TBCB", "TBCD", "TBCE", "TCEA1", "TCERG1", "TCP1", "TDRKH", "TECR", "TFCP2", "TFRC", "THADA", "THOC1", "THOC2", "THOC3", "THOP1", "THRAP3", "TJP1", "TK1", "TKT", "TM9SF3", "TM9SF4", "TMED10", "TMED2", "TMED5", "TMED7", "TMED9", "TMEM259", "TMEM97", "TMOD3", "TMPO", "TNPO1", "TNPO3", "TOE1", "TOMM20", "TOMM40", "TOP1", "TP53", "TP53BP2", "TPI1", "TPM1", "TPM3", "TPM4", "TPP1", "TPP2", "TPT1", "TPX2", "TRA2A", "TRA2B", "TRAF2", "TRAP1", "TRAPPC4", "TRIO", "TRMT6", "TROVE2", "TRUB1", "TSFM", "TSG101", "TTK", "TTYH3", "TUBB", "TUBB2A", "TUBB2B", "TUBB4A", "TUBB4B", "TUBB6", "TUBGCP2", "TUBGCP3", "TUFM", "TWF1", "TWF2", "TXLNA", "TXLNG", "TXNDC12", "TXNDC17", "TXNDC9", "TXNRD1", "TYMS", "U2SURP", "UBA1", "UBA2", "UBA3", "UBA6", "UBE2L3", "UBE4A", "UCHL5", "UCK2", "UGCG", "UGGT1", "UNC119B", "UPF1", "UQCR10", "UQCRC1", "UQCRC2", "USO1", "USP10", "USP11", "USP14", "USP28", "USP34", "USP39", "USP47", "USP5", "USP7", "USP8", "UTP14A", "UTP6", "VAMP7", "VAPA", "VAPB", "VBP1", "VKORC1L1", "VMP1", "VPS18", "VPS26A", "VPS29", "VPS33B", "VPS35", "VPS4A", "VPS4B", "VRK1", "WARS", "WDHD1", "WDR1", "WDR33", "WDR4", "WIZ", "XAB2", "XPO1", "XPO4", "XPO5", "XPO7", "XPOT", "XRCC5", "XRCC6", "YARS", "YARS2", "YLPM1", "YME1L1", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2", "ZC3H11A", "ZC3H15", "ZCCHC11", "ZCCHC8", "ZFR", "ZMPSTE24", "ZMYM4", "ZW10", "ZYX"], "leading_proteins": ["ABCB1", "ACAT2", "ACOX1", "ACP2", "ADI1", "AK1", "AK2", "AK3", "ALDH9A1", "ALG1", "ALG12", "APOL2", "APP", "ASAH1", "ATP1A1", "ATP1B1", "ATP2A2", "ATP5F1", "ATP6AP2", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP7B", "BAIAP2", "CALU", "CAMK1", "CBX1", "CBX5", "CCNB1", "CCNB2", "CDC37", "CLCN3", "CLUH", "COL4A3BP", "COLEC12", "COMT", "COQ3", "COX7A2", "CPSF3", "CPT2", "CPVL", "CRTAP", "CSGALNACT2", "CTSA", "CTSB", "CTSC", "CYB5B", "CYP51A1", "DERL1", "DHCR24", "DHCR7", "DNM1L", "DSC3", "ECE1", "EEF1B2", "EIF3L", "EIF5", "ELP3", "EPHA7", "ERAP1", "FOXRED1", "GAA", "GALNT1", "GALNT2", "GGH", "GLB1", "GLUD1", "GM2A", "GNAI2", "GNS", "HEXA", "HEXB", "IGF2R", "INTS11", "IPO7", "KDELR1", "LAMP1", "LBR", "LETM1", "LGMN", "LNPEP", "MANBA", "MBOAT7", "ME1", "MFSD3", "MFSD5", "MIA2", "MPC2", "MPV17L2", "MRPL44", "MTCH1", "NAMPT", "NDUFS2", "NLN", "NNT", "NPEPPS", "NRDC", "NSUN2", "NT5C3B", "NTMT1", "NUCB1", "NUCB2", "NUP54", "OLA1", "OTUB1", "P3H1", "PDCD4", "PGRMC1", "PGRMC2", "PITRM1", "PLA2G15", "PLBD2", "PLD6", "PMPCA", "PPT1", "PPT2", "PRCP", "PRKAG1", "PTGES2", "PXMP2", "QSOX2", "RALA", "RAP2B", "RCN2", "REEP4", "REEP5", "RNASEH2A", "SC5D", "SCARB1", "SCARB2", "SCPEP1", "SDCBP", "SFXN2", "SHMT1", "SLC12A2", "SLC12A9", "SLC16A1", "SLC1A5", "SLC25A10", "SLC25A11", "SLC25A15", "SLC25A19", "SLC25A20", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A4", "SLC25A42", "SLC25A44", "SLC25A5", "SLC25A6", "SLC27A2", "SLC29A1", "SLC30A5", "SLC35B2", "SLC35F1", "SLC35F2", "SLC38A2", "SLC3A2", "SLC4A7", "SMN1*", "SMYD3", "SORT1", "SPNS1", "SPPL2A", "SPTLC1", "SQLE", "STAMBP", "STOM", "STT3A", "STX18", "STX5", "STX7", "STX8", "STXBP3", "SURF4", "SYNGR2", "SYS1", "TFRC", "TM9SF3", "TM9SF4", "TMEM97", "TNPO1", "TOMM20", "TPP1", "TSFM", "TTYH3", "TXNDC12", "UGCG", "UNC119B", "UQCR10", "VAMP7", "VMP1", "ZADH2", "ZMPSTE24"]} \ No newline at end of file diff --git a/pharos_protein_category/advanced/idx2term.json b/pharos_protein_category/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..6e0847ffc649d08286e63465c7dfff7898d31ecd --- /dev/null +++ b/pharos_protein_category/advanced/idx2term.json @@ -0,0 +1 @@ +{"0": "Tbio"} \ No newline at end of file diff --git a/pharos_protein_category/advanced/plot_0.png b/pharos_protein_category/advanced/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..6380343d810dcaf734b13bc4a4d62ad75c075345 --- /dev/null +++ b/pharos_protein_category/advanced/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:099987fd5809c05caca5881391c4eb224d72b9a1a1b68d43c206b022c7f65bea +size 209033 diff --git a/pharos_protein_category/basic/idx2term.json b/pharos_protein_category/basic/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..ddd662d46a4f8971ba47d18342352a728e89ddee --- /dev/null +++ b/pharos_protein_category/basic/idx2term.json @@ -0,0 +1 @@ +{"0": "Tbio", "1": "Tclin"} \ No newline at end of file diff --git a/pharos_protein_category/basic/plot_0.png b/pharos_protein_category/basic/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..bccb5420d5c15a5550db7997e7ce0a8a28235480 --- /dev/null +++ b/pharos_protein_category/basic/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:3d87ac27110efaec71c8efd083927f7f7fe5c5e95347542ff3195996995bcff5 +size 128836 diff --git a/pharos_protein_category/basic/plot_1.png b/pharos_protein_category/basic/plot_1.png new file mode 100644 index 0000000000000000000000000000000000000000..9e4fad29b008c1170b94de40e02df06e8ddc95ac --- /dev/null +++ b/pharos_protein_category/basic/plot_1.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:d373874a94a208f013fb654401e63f2876cbb00967e89bc47b9265254518aaf1 +size 132982 diff --git a/pharos_protein_category/consensus.joblib b/pharos_protein_category/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..eb64170ecf5bd59c568260d4014ef06c021914f6 --- /dev/null +++ b/pharos_protein_category/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:dea3b52938283333d7038202b772bac17641cd69e26a4ee70cd98acd427bf18c +size 65444 diff --git a/pharos_protein_category/df_merge.tsv b/pharos_protein_category/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..23de4b7cc90c91d397590061fbe62b0430f94056 --- /dev/null +++ b/pharos_protein_category/df_merge.tsv @@ -0,0 +1,2 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Tbio 281 2046 4.761396960505148 1.9225745397261085e-06 467.6796116504854 2434.25 -0.5416405556668178 0.3215141878443288 119.73666199244032 234.70955636597876 4.704421961664106 0.4116627836259234 0.98196877224181 0.8296675543855808 0.9888316674690428 0.7897014010530075 0.3499478613335164 diff --git a/pharos_protein_category/metrics.json b/pharos_protein_category/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..5bd11e122cb7fecf896036e509eb14ee37a74409 --- /dev/null +++ b/pharos_protein_category/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2644, + "annotations_size": 4, + "title": "Average number of proteins per term", + "value": 660.75 +} \ No newline at end of file diff --git a/pharos_protein_category/paths.json b/pharos_protein_category/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..c77443cb59eb69d9a73e493eb84150f40a89a5cc --- /dev/null +++ b/pharos_protein_category/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/pharos_protein_category/fragment/C197/C197_val_log2fc"} \ No newline at end of file diff --git a/pharos_protein_category/result.tsv b/pharos_protein_category/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..0e74c92a68259263e730ffe26a92f803f8dfc885 --- /dev/null +++ b/pharos_protein_category/result.tsv @@ -0,0 +1,3 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Tbio 0.1742542524347262 4.761396960505148 1.9225745397261085e-06 7.690275981179695e-06 7.690298158908434e-06 2046 Q8NHP8,Q99595,Q9UM22,Q9NWT6,O75503,Q9HB40,O00584,O43657,P50897,Q9BQE5,P80303,P07602,P15586,P21796,Q8IZA0,O60637,Q9C0H2,Q8TCT8,Q14108,Q9H6V9,O00115,Q9NUJ1,Q08380,O75976,Q9NQX7,P61916,Q9H061,Q96FW1,P27105,O43169,P11117,O75153,O75844,P54802,Q567V2,Q93050,Q8N4Q0,Q8IV08,O14773,O00461,Q9H2D1,Q06481,Q9UHG3,Q9NS69,P24390,Q8NCC3,Q92896,Q16740,Q15392,Q16625,Q9H3G5,P10321,P28070,Q5KU26,Q14574,P17900,O43505,O95772,P11279,Q9Y487,Q9UQB8,P02786,Q8N511,O15173,Q15067,Q06136,Q86XL3,Q9Y680,O15118,Q9NQZ5,Q92542,A6NIH7,Q86UY6,Q8TB61,Q9NTK5,O94813,Q6ZRP7,Q9Y282,Q9UDW1,Q9UMR5,Q8NBQ5,Q14257,Q13501,O15260,O43852,P67812,Q01844,Q96G23,Q01459,Q9Y619,Q9UBU6,P35637,P43307,Q13505,Q9UQ84,Q6DKK2,Q06787,Q14126,O95628,P01889,Q8N2A8,O14975,O75787,P55010,Q8IXH7,Q9NWM8,O75845,Q9UMX5,Q8IY95,P04439,Q14739,Q9NUG6,Q8NFQ8,O00592,Q9UHX1,Q9Y3D6,Q9BWD1,O15127,Q92804,Q96GC9,Q9BUN8,P55209,O14979,P11233,Q96N66,O60831,P50402,O00560,Q9UFC0,P35613,O43760,P35270,Q32P28,Q9BTX1,Q9H2C2,Q96A57,Q99733,Q9NQW6,O43772,Q70HW3,Q8TAD4,Q9NZW5,O95197,O75718,Q9Y277,Q9H9T3,Q8TAA9,O75955,O96005,P61225,Q9Y5P4,O14949,Q96CU9,O95630,Q8NCH0,Q9NX40,O00264,P51809,Q07021,Q96EK5,Q9Y6M7,Q9BUR5,Q96QD8,Q8NB78,P51116,P28072,O60506,P04899,Q9P2W9,Q14254,Q9H3K2,O15400,Q16836,Q9HA64,P31942,P11177,O95881,P52597,Q9UBX3,Q9Y262,P08195,Q9NR12,Q5VT66,P22626,Q9H2J4,Q92791,Q9HCL2,Q92544,P31943,P49189,Q10713,P46108,Q9NNW5,Q96DY7,Q9H6H4,P10644,O00429,O75477,Q15041,Q92945,Q99729,Q99735,Q02241,Q9BV57,Q6P1A2,Q5XKP0,P20645,P35670,P46379,O43847,P51114,Q9UNK0,Q10472,Q9Y5B8,Q9H223,Q14103,P48723,Q01085,P51991,P24539,Q9H4M9,Q9HCE1,Q16637,Q14011,O43681,O43390,P05198,P38159,Q92733,Q9Y4P3,Q6P4Q7,Q96KA5,Q9P016,P51648,Q96A33,Q8N6G5,Q5T9L3,P55795,Q00765,Q8NBX0,Q53GQ0,O14880,Q8IY67,Q99436,Q9H6K4,Q15555,Q13423,O95373,Q99547,P00367,P50995,P53990,P78310,Q9BYT8,Q9Y5A9,Q9BV10,P49321,Q9BV86,P16435,P30154,O95563,O95140,O75569,Q99956,Q9NZJ7,Q9H0H5,Q9BWF3,Q96L92,P12235,O95831,O60879,O15397,Q9UL15,Q9NZJ6,Q9NXV2,Q9BRR6,Q96PK6,Q01658,O95456,O14737,O14654 281 +Tclin 0.4189125162553104 1.6657288232456438 0.0957674383798137 0.3314705121777659 0.1915348767596274 76 O96000,P05026,P20618,P10253,P21964,O75306,O43676,P06280,Q99720,Q16739,P49721,P48735 12 diff --git a/pharos_protein_category/selections.json b/pharos_protein_category/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..dcbafb1b7c866e08b527612ade751941a6c209e7 --- /dev/null +++ b/pharos_protein_category/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["Tbio", "Tchem", "Tclin", "Tdark"], "available_proteins": ["AAAS", "AAMP", "AARS", "AARS2", "AASDHPPT", "AATF", "ABCB1", "ABCB7", "ABCD3", "ABCE1", "ABCF1", "ABCF2", "ABCF3", "ABHD10", "ABHD12", "ABHD14B", "ABHD6", "ABI1", "ABRAXAS2", "ACAA2", "ACACA", "ACACB", "ACAD9", "ACADM", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACIN1", "ACLY", "ACO2", "ACOT13", "ACOT7", "ACOT9", "ACOX1", "ACOX3", "ACP1", "ACP2", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN2", "ACTN4", "ACTR1A", "ACTR2", "ACTR3", "ADAR", "ADD1", "ADD3", "ADH5", "ADI1", "ADK", "ADNP", "ADPGK", "ADPRHL2", "ADRM1", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGK", "AGL", "AGPAT1", "AGPS", "AHCY", "AHCYL1", "AHNAK", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AK3", "AKAP1", "AKAP12", "AKAP13", "AKAP17A", "AKAP8", "AKAP8L", "AKR1A1", "AKR1B1", "AKR7A2", "AKT2", "ALDH16A1", "ALDH18A1", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALG1", "ALG12", "ALKBH5", "AMOT", "ANAPC1", "ANAPC10", "ANAPC5", "ANAPC7", "ANKLE2", "ANKRD17", "ANLN", "ANO10", "ANP32A", "ANP32B", "ANXA1", "ANXA11", "ANXA2", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP1M1", "AP1S2", "AP2A1", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "APEH", "APEX1", "APEX2", "API5", "APLP2", "APMAP", "APOL2", "APOO", "APOOL", "APP", "APRT", "AQR", "ARCN1", "ARF4", "ARFGAP1", "ARFGAP2", "ARFIP1", "ARFIP2", "ARHGAP17", "ARHGDIA", "ARHGEF2", "ARID1A", "ARID3B", "ARIH1", "ARIH2", "ARL1", "ARL10", "ARL2", "ARL3", "ARL6IP1", "ARL6IP5", "ARMC10", "ARMC6", "ARMCX3", "ARMT1", "ARPC1A", "ARPC2", "ARPC3", "ARPC4", "ARSA", "ARV1", "ASAH1", "ASCC2", "ASCC3", "ASH2L", "ASNA1", "ASNS", "ASPH", "ASPSCR1", "ASRGL1", "ATAD1", "ATAD3A", "ATAD3B", "ATG3", "ATIC", "ATL2", "ATP13A1", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2C1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6", "ATP6AP1", "ATP6AP2", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1D", "ATP6V1E1", "ATP6V1G1", "ATP6V1H", "ATP7B", "ATPAF1", "ATPIF1", "ATXN10", "ATXN2L", "AUP1", "AURKA", "B4GAT1", "BAG3", "BAG5", "BAG6", "BAIAP2", "BANF1", "BAZ1A", "BAZ1B", "BCAP31", "BCAS3", "BCCIP", "BCLAF1", "BCS1L", "BICD2", "BIRC6", "BLMH", "BLVRA", "BMS1", "BOLA2*", "BOP1", "BPNT1", "BPTF", "BRAP", "BRAT1", "BRD1", "BRD2", "BRIX1", "BSG", "BTAF1", "BTF3", "BUB1B", "BUB3", "BUD23", "BUD31", "BYSL", "BZW1", "BZW2", "C12orf73", "C17orf75", "C19orf70", "C1QBP", "C1orf122", "C1orf123", "C1orf35", "C5orf15", "C5orf51", "C8orf33", "CAB39", "CACUL1", "CACYBP", "CAD", "CALCOCO1", "CALD1", "CALM3", "CALR", "CALU", "CAMK1", "CAMK2G", "CAND1", "CAND2", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPNS1", "CAPRIN1", "CAPZA1", "CAPZA2", "CAPZB", "CARM1", "CARS", "CASK", "CAST", "CBL", "CBR1", "CBX1", "CBX2", "CBX3", "CBX5", "CCAR1", "CCAR2", "CCDC124", "CCDC138", "CCDC22", "CCDC47", "CCDC6", "CCDC86", "CCNB1", "CCNB2", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2AP", "CDC123", "CDC20", "CDC23", "CDC25C", "CDC27", "CDC34", "CDC37", "CDC40", "CDC42", "CDC5L", "CDC73", "CDCA8", "CDK1", "CDK2", "CDK4", "CDK5", "CDK5RAP3", "CDK6", "CDKN2AIP", "CDV3", "CDX2", "CEBPZ", "CENPF", "CENPP", "CEP55", "CEPT1", "CERS2", "CETN2", "CFAP20", "CFL1", "CFL2", "CHAC2", "CHAF1A", "CHAF1B", "CHAMP1", "CHCHD3", "CHD4", "CHERP", "CHID1", "CHKA", "CHM", "CHMP2A", "CHMP2B", "CHMP7", "CHORDC1", "CHRAC1", "CHST14", "CHUK", "CIAPIN1", "CIP2A", "CIRBP", "CISD2", "CIZ1", "CKAP2", "CKAP4", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLASP2", "CLCC1", "CLCN3", "CLCN7", "CLGN", "CLIC1", "CLIC4", "CLINT1", "CLIP1", "CLN5", "CLNS1A", "CLPB", "CLPP", "CLPTM1", "CLPTM1L", "CLPX", "CLTC", "CLUH", "CMAS", "CMPK1", "CMTR1", "CNDP2", "CNN2", "CNN3", "CNNM4", "CNOT1", "CNOT2", "CNOT3", "CNOT4", "CNOT7", "CNOT9", "CNP", "CNPY2", "COIL", "COL4A3BP", "COLEC12", "COLGALT1", "COMMD2", "COMT", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS7A", "COPS7B", "COPS8", "COPZ1", "COQ3", "COQ8A", "COQ9", "CORO1A", "CORO1C", "CORO7", "COTL1", "COX4I1", "COX5A", "COX6C", "COX7A2", "CPD", "CPNE1", "CPNE3", "CPOX", "CPSF1", "CPSF3", "CPSF6", "CPSF7", "CPT2", "CPVL", "CRK", "CRKL", "CRNKL1", "CRTAP", "CRYZ", "CS", "CSDE1", "CSE1L", "CSGALNACT2", "CSK", "CSNK1A1", "CSNK2A1", "CSNK2A2", "CSNK2B", "CSTB", "CSTF1", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTBS", "CTH", "CTNNA1", "CTNNAL1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTPS2", "CTSA", "CTSB", "CTSC", "CTTN", "CTU2", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CWF19L1", "CXADR", "CXorf56", "CXorf57", "CYB5B", "CYB5D2", "CYB5R1", "CYB5R3", "CYC1", "CYFIP1", "CYP20A1", "CYP51A1", "DAP3", "DARS", "DARS2", "DAZAP1", "DBN1", "DBNL", "DCAF1", "DCAF7", "DCAKD", "DCD", "DCPS", "DCTN1", "DCTN2", "DCTN3", "DCTN4", "DCTPP1", "DCUN1D4", "DCXR", "DDB1", "DDI2", "DDOST", "DDRGK1", "DDT", "DDX1", "DDX10", "DDX17", "DDX18", "DDX20", "DDX21", "DDX23", "DDX24", "DDX27", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX50", "DDX51", "DDX52", "DDX54", "DDX56", "DDX6", "DEK", "DENR", "DERL1", "DFFA", "DHCR24", "DHCR7", "DHFR", "DHRS1", "DHRS7", "DHX15", "DHX16", "DHX29", "DHX30", "DHX36", "DHX37", "DHX8", "DHX9", "DIABLO", "DIAPH1", "DIAPH2", "DIAPH3", "DIDO1", "DIEXF", "DIMT1", "DIS3", "DKC1", "DLAT", "DLD", "DLST", "DNA2", "DNAAF5", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC2", "DNAJC3", "DNAJC7", "DNAJC8", "DNAJC9", "DNASE2", "DNM1L", "DNM2", "DNMT1", "DNPH1", "DNTTIP2", "DOCK7", "DOHH", "DPH2", "DPH5", "DPM1", "DPP3", "DPP9", "DPY30", "DPYSL2", "DPYSL5", "DR1", "DRG1", "DRG2", "DSC1", "DSC3", "DSG2", "DSP", "DST", "DSTN", "DTYMK", "DUSP12", "DUSP3", "DUSP9", "DUT", "DYNC1H1", "DYNC1LI1", "DYNC1LI2", "DYNC2H1", "DYNLL1", "EBNA1BP2", "ECD", "ECE1", "ECH1", "ECHS1", "ECI1", "ECI2", "ECSIT", "EDC3", "EDC4", "EDF1", "EDRF1", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EFHD1", "EFL1", "EFTUD2", "EHD1", "EHD4", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2D", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A3", "EIF4B", "EIF4E", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "ELAC2", "ELAVL1", "ELMO2", "ELMOD2", "ELOA", "ELOB", "ELOC", "ELP1", "ELP2", "ELP3", "ELP4", "EMC1", "EMC2", "EMC7", "EMD", "EMG1", "ENAH", "ENDOD1", "ENO1", "ENO2", "ENSA", "EPB41", "EPB41L2", "EPB41L5", "EPDR1", "EPHA7", "EPHX1", "EPHX2", "EPPK1", "EPRS", "EPS15", "EPS15L1", "ERAL1", "ERAP1", "ERCC2", "ERG28", "ERGIC3", "ERH", "ERI1", "ERLIN1", "ERLIN2", "ERMP1", "ERO1A", "ERP29", "ESD", "ESF1", "ESYT1", "ETF1", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXO1", "EXOC2", "EXOC3", "EXOC5", "EXOC7", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "EZR", "FAF1", "FAF2", "FAH", "FAHD1", "FAM114A2", "FAM129B", "FAM162A", "FAM192A", "FAM208A", "FAM213A", "FAM49B", "FAM8A1", "FAM98B", "FANCI", "FAR1", "FARSA", "FARSB", "FASN", "FAU", "FBL", "FBXO22", "FBXO7", "FCGRT", "FDFT1", "FDPS", "FECH", "FEN1", "FGFR1OP", "FH", "FHOD1", "FIP1L1", "FIS1", "FKBP10", "FKBP14", "FKBP1A", "FKBP3", "FKBP4", "FKBP5", "FKBP7", "FKBP8", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FMR1", "FN3KRP", "FNTB", "FOXRED1", "FRG1", "FSCN1", "FTO", "FTSJ3", "FUBP1", "FUBP3", "FUCA1", "FUCA2", "FUNDC2", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GADD45GIP1", "GAK", "GALK1", "GALM", "GALNT1", "GALNT2", "GALNT7", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GBA", "GBF1", "GCAT", "GCDH", "GCFC2", "GCLC", "GCLM", "GCN1", "GDI1", "GDI2", "GDPD1", "GEMIN4", "GEMIN5", "GET4", "GFM1", "GFPT1", "GGCT", "GGCX", "GGH", "GGNBP2", "GHDC", "GHITM", "GIGYF2", "GINS3", "GINS4", "GLA", "GLB1", "GLDC", "GLG1", "GLMN", "GLO1", "GLOD4", "GLRX", "GLRX3", "GLRX5", "GLS", "GLUD1", "GLYR1", "GM2A", "GMFB", "GMPPB", "GMPS", "GNA13", "GNAI1", "GNAI2", "GNAI3", "GNL1", "GNL2", "GNL3", "GNL3L", "GNPAT", "GNPDA1", "GNS", "GOLGA3", "GOLGB1", "GOLIM4", "GOLT1B", "GOPC", "GORASP2", "GOT1", "GOT2", "GPAM", "GPATCH11", "GPATCH4", "GPD2", "GPI", "GPKOW", "GPR107", "GPR108", "GPS1", "GRB2", "GRHPR", "GRIPAP1", "GRPEL1", "GRSF1", "GRWD1", "GSK3B", "GSPT1", "GSR", "GSS", "GSTK1", "GSTM3", "GSTO1", "GSTZ1", "GTF2I", "GTF3C1", "GTF3C2", "GTF3C3", "GTF3C4", "GTPBP1", "GTPBP10", "GTPBP3", "GTPBP4", "GUF1", "GUSB", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACD3", "HACL1", "HADH", "HADHA", "HADHB", "HAT1", "HAUS3", "HAUS5", "HAUS8", "HBS1L", "HCCS", "HCFC1", "HDAC2", "HDGF", "HDGFL2", "HDHD2", "HDHD5", "HDLBP", "HEATR1", "HEATR3", "HEBP1", "HEBP2", "HECTD1", "HECTD3", "HELLS", "HEXA", "HEXB", "HIBADH", "HIBCH", "HIF1AN", "HIGD2A", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HLTF", "HM13", "HMBS", "HMCES", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMGCS1", "HMGN2", "HMOX1", "HMOX2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPLL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HNRNPUL2", "HP1BP3", "HPF1", "HPRT1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSDL1", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA13", "HSPA14", "HSPA1B", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPB1", "HSPBP1", "HSPD1", "HSPE1", "HSPH1", "HTATIP2", "HUWE1", "HYOU1", "IARS", "IARS2", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDI1", "IFT27", "IGBP1", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IK", "IKBIP", "ILF2", "ILF3", "ILKAP", "ILVBL", "IMMT", "IMP4", "IMPACT", "IMPDH1", "IMPDH2", "INA", "INCENP", "INTS11", "INTS14", "INTS7", "INTS9", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IRF2BPL", "IRGQ", "IRS4", "ISCU", "ISOC1", "IST1", "ISYNA1", "ITGB1", "ITM2C", "ITPA", "IVD", "JPT2", "JUP", "KARS", "KCTD12", "KCTD5", "KDELC2", "KDELR1", "KDM1A", "KDM1B", "KDM3B", "KDSR", "KHDRBS1", "KHSRP", "KIAA0319L", "KIAA0368", "KIAA0391", "KIAA1147", "KIAA2013", "KIF11", "KIF15", "KIF18B", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF4A", "KIF5B", "KIF7", "KIFBP", "KIFC1", "KLC1", "KMT2A", "KNTC1", "KPNA1", "KPNA2", "KPNA3", "KPNB1", "KRI1", "KRR1", "KTN1", "LAMP1", "LAMTOR1", "LANCL2", "LAP3", "LARP1", "LARP4", "LARP4B", "LARS", "LARS2", "LAS1L", "LASP1", "LBR", "LCLAT1", "LDAH", "LDHA", "LDHB", "LEMD2", "LEMD3", "LETM1", "LGALS3", "LGALS3BP", "LGMN", "LIG1", "LIG3", "LIMA1", "LIPA", "LLGL1", "LMAN1", "LMAN2", "LMNA", "LMNB1", "LMNB2", "LNPEP", "LONP1", "LPCAT1", "LPCAT3", "LPGAT1", "LRBA", "LRPPRC", "LRRC40", "LRRC47", "LRRC57", "LRRC59", "LRWD1", "LSM12", "LSM14B", "LSM2", "LSM6", "LSM7", "LSS", "LTA4H", "LTN1", "LTV1", "LUC7L2", "LUC7L3", "LYAR", "LYPLA1", "M6PR", "MACF1", "MAD2L1", "MAGED2", "MAN2A1", "MAN2B1", "MANBA", "MANF", "MAP1B", "MAP1S", "MAP2K1", "MAP4", "MAPK1", "MAPRE1", "MAPRE2", "MARC1", "MARCKS", "MARS", "MAT2A", "MAT2B", "MATR3", "MAVS", "MBD3", "MBOAT7", "MCAT", "MCCC1", "MCCC2", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCMBP", "MCU", "MDC1", "MDH1", "MDH2", "MDN1", "ME1", "MECP2", "MED1", "MED21", "MED23", "MED24", "MED25", "MED4", "MFN2", "MFSD10", "MFSD3", "MFSD5", "MGEA5", "MGST2", "MGST3", "MIA2", "MICU1", "MID1", "MIF", "MINDY3", "MINPP1", "MIPEP", "MKI67", "MKRN2", "MLEC", "MMGT1", "MMS19", "MOGS", "MORF4L1", "MORF4L2", "MOSPD2", "MOV10", "MPC2", "MPHOSPH10", "MPHOSPH6", "MPI", "MPP6", "MPRIP", "MPST", "MPV17L2", "MRE11", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL14", "MRPL15", "MRPL19", "MRPL21", "MRPL28", "MRPL3", "MRPL37", "MRPL38", "MRPL39", "MRPL40", "MRPL44", "MRPL45", "MRPL46", "MRPL47", "MRPL48", "MRPL49", "MRPL50", "MRPL53", "MRPL9", "MRPS11", "MRPS2", "MRPS22", "MRPS23", "MRPS25", "MRPS27", "MRPS28", "MRPS30", "MRPS31", "MRPS33", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRPS9", "MRTO4", "MSH2", "MSH3", "MSH6", "MSI2", "MSN", "MSTO1", "MTA1", "MTA2", "MTAP", "MTBP", "MTCH1", "MTCH2", "MTDH", "MTHFD1", "MTHFD1L", "MTHFD2", "MTMR2", "MTMR6", "MTOR", "MTPAP", "MTPN", "MTR", "MTX1", "MTX2", "MVK", "MYBBP1A", "MYCBP", "MYDGF", "MYG1", "MYH10", "MYH14", "MYH9", "MYL6", "MYO1B", "MYO1C", "MYO1D", "MYO6", "NAA15", "NAA25", "NAA40", "NAA50", "NAE1", "NAF1", "NAGLU", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NAPG", "NARS", "NASP", "NAT10", "NAXE", "NBN", "NCAPD2", "NCAPG", "NCAPH", "NCBP1", "NCDN", "NCKAP1", "NCKIPSD", "NCL", "NCLN", "NCOA5", "NCSTN", "NDC1", "NDRG3", "NDUFA10", "NDUFA3", "NDUFA4", "NDUFA5", "NDUFA7", "NDUFA9", "NDUFAF4", "NDUFAF7", "NDUFB10", "NDUFB3", "NDUFB4", "NDUFB5", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS6", "NDUFS7", "NDUFV1", "NDUFV2", "NECAP1", "NECAP2", "NEFL", "NEFM", "NEK9", "NELFA", "NELFB", "NELFCD", "NELFE", "NEMF", "NENF", "NES", "NFU1", "NHLRC2", "NHP2", "NIFK", "NIPBL", "NKRF", "NLE1", "NLN", "NMD3", "NME1", "NME6", "NME7", "NMT1", "NNT", "NOB1", "NOC2L", "NOC3L", "NOC4L", "NOL10", "NOL11", "NOL6", "NOL7", "NOL9", "NOLC1", "NOM1", "NONO", "NOP14", "NOP2", "NOP53", "NOP56", "NOP58", "NOSIP", "NPC1", "NPC2", "NPEPPS", "NPLOC4", "NPM1", "NRDC", "NRP1", "NSA2", "NSD2", "NSDHL", "NSF", "NSFL1C", "NSUN2", "NSUN5", "NT5C2", "NT5C3B", "NT5DC1", "NT5DC2", "NTHL1", "NTMT1", "NTPCR", "NUB1", "NUBP2", "NUCB1", "NUCB2", "NUCKS1", "NUDC", "NUDCD2", "NUDT1", "NUDT12", "NUDT21", "NUDT5", "NUF2", "NUFIP2", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP160", "NUP188", "NUP205", "NUP210", "NUP214", "NUP37", "NUP43", "NUP50", "NUP54", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NUPL2", "NVL", "NXF1", "NXN", "OAT", "OCIAD1", "OCLN", "OCRL", "OGDH", "OGT", "OLA1", "OPA1", "OPA3", "OSBP", "OSBPL8", "OSBPL9", "OSGEP", "OTUB1", "OTULIN", "OXA1L", "OXSR1", "P3H1", "P3H4", "P4HA1", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PAF1", "PAFAH1B1", "PAFAH1B2", "PAFAH1B3", "PAICS", "PAK1", "PAK1IP1", "PAK2", "PANK4", "PAPOLA", "PAPSS1", "PARK7", "PARN", "PARP1", "PATL1", "PBDC1", "PBK", "PBRM1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCK2", "PCLAF", "PCM1", "PCMT1", "PCNA", "PCNP", "PCYOX1", "PDAP1", "PDCD11", "PDCD4", "PDCD5", "PDCD6", "PDCD6IP", "PDCL3", "PDE12", "PDE6D", "PDHA1", "PDHB", "PDIA3", "PDIA4", "PDIA6", "PDK1", "PDK3", "PDLIM1", "PDLIM3", "PDLIM5", "PDLIM7", "PDPR", "PDRG1", "PDS5A", "PDS5B", "PDXDC1", "PDXK", "PEBP1", "PECR", "PEF1", "PELO", "PELP1", "PEPD", "PES1", "PEX14", "PEX19", "PFAS", "PFDN2", "PFDN4", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGGT1B", "PGK1", "PGLS", "PGM1", "PGM2", "PGM3", "PGP", "PGRMC1", "PGRMC2", "PHB", "PHB2", "PHF14", "PHF5A", "PHF6", "PHF8", "PHGDH", "PHIP", "PHKA1", "PICALM", "PIGT", "PIH1D1", "PIK3C2A", "PIK3R4", "PIN1", "PIN4", "PIP4K2C", "PIR", "PISD", "PITHD1", "PITPNB", "PITRM1", "PKM", "PKMYT1", "PKN2", "PLA2G15", "PLAA", "PLBD2", "PLCG1", "PLD3", "PLD6", "PLEC", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLRG1", "PLS3", "PM20D2", "PMPCA", "PMPCB", "PNN", "PNO1", "PNP", "PNPT1", "PODXL", "POGZ", "POLA1", "POLA2", "POLD1", "POLD2", "POLD3", "POLDIP2", "POLDIP3", "POLE", "POLE3", "POLE4", "POLR1A", "POLR1B", "POLR1E", "POLR2A", "POLR2B", "POLR2C", "POLR2G", "POLR3A", "POLR3C", "POLRMT", "PON2", "POP1", "POR", "PPA1", "PPA2", "PPAN", "PPAT", "PPFIA1", "PPHLN1", "PPIB", "PPID", "PPIF", "PPIG", "PPIH", "PPIL4", "PPM1G", "PPME1", "PPP1CA", "PPP1CB", "PPP1R10", "PPP1R7", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP4C", "PPP4R1", "PPP5C", "PPP6C", "PPT1", "PPT2", "PQBP1", "PRAF2", "PRCC", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PREP", "PREPL", "PRIM1", "PRIM2", "PRKAG1", "PRKAR1A", "PRKAR2A", "PRKCD", "PRKCSH", "PRKDC", "PRKRA", "PRMT1", "PRMT3", "PRMT5", "PRMT9", "PRPF19", "PRPF3", "PRPF31", "PRPF38B", "PRPF39", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPS1", "PRPSAP1", "PRPSAP2", "PRRC1", "PRRC2A", "PRRC2C", "PSAP", "PSAT1", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD6", "PSMD7", "PSMD8", "PSME1", "PSME2", "PSME3", "PSME4", "PSMF1", "PSMG1", "PSMG2", "PSPC1", "PTBP1", "PTBP2", "PTCD1", "PTCD3", "PTDSS1", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK7", "PTPA", "PTPN1", "PTPN11", "PTRH2", "PTRHD1", "PUF60", "PUM3", "PURA", "PUS1", "PUS7", "PWP1", "PWP2", "PXMP2", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QDPR", "QKI", "QSOX2", "RAB10", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB21", "RAB23", "RAB24", "RAB2A", "RAB35", "RAB3GAP2", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RAB8A", "RABEPK", "RABGAP1", "RABGGTA", "RABL6", "RAC1", "RACGAP1", "RACK1", "RAD21", "RAD23A", "RAD23B", "RAD50", "RAE1", "RAI14", "RALA", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP9", "RANGAP1", "RANGRF", "RAP2B", "RAPGEF2", "RARS", "RARS2", "RAVER1", "RB1", "RBBP4", "RBBP6", "RBBP7", "RBM10", "RBM12", "RBM12B", "RBM14", "RBM17", "RBM19", "RBM22", "RBM25", "RBM26", "RBM27", "RBM28", "RBM3", "RBM34", "RBM39", "RBM4", "RBM5", "RBM8A", "RBMX", "RCC1", "RCC2", "RCL1", "RCN1", "RCN2", "RCOR1", "RDH11", "RDH13", "RDX", "RECQL", "REEP4", "REEP5", "RELA", "REPS1", "RER1", "RETSAT", "REXO4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RHEB", "RHOT1", "RHOT2", "RIDA", "RIF1", "RINT1", "RIOK2", "RIOX1", "RMC1", "RMDN3", "RNASEH2A", "RNASET2", "RNF2", "RNF40", "RNH1", "RNPEP", "ROCK1", "ROCK2", "RPA1", "RPA2", "RPAP1", "RPAP3", "RPF2", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPN1", "RPN2", "RPP30", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RRBP1", "RRM1", "RRM2", "RRP1", "RRP12", "RRP15", "RRP1B", "RRP8", "RRS1", "RSF1", "RSL1D1", "RSL24D1", "RSU1", "RTCB", "RTFDC1", "RTN3", "RTN4", "RTRAF", "RUFY1", "RUVBL1", "RUVBL2", "RWDD1", "S100A10", "S100A11", "S100A13", "SACM1L", "SAE1", "SAFB", "SAFB2", "SAMHD1", "SAMM50", "SAP130", "SAP18", "SAP30BP", "SAR1A", "SARNP", "SARS", "SARS2", "SART1", "SART3", "SASS6", "SBDS", "SC5D", "SCAMP2", "SCAMP3", "SCARB1", "SCARB2", "SCCPDH", "SCD", "SCFD1", "SCML2", "SCO1", "SCO2", "SCP2", "SCPEP1", "SCRIB", "SCRN1", "SDCBP", "SDE2", "SDF4", "SDHA", "SDHB", "SDR39U1", "SEC11A", "SEC16A", "SEC22B", "SEC23A", "SEC23IP", "SEC24A", "SEC24B", "SEC24C", "SEC24D", "SEC31A", "SEC61A1", "SEC61B", "SEC61G", "SEC62", "SEC63", "SEH1L", "SEL1L", "SENP3", "SEPHS1", "SEPT2", "SEPT7", "SEPT9", "SERBP1", "SERPINB6", "SERPINH1", "SET", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFSWAP", "SFXN1", "SFXN2", "SFXN4", "SGPL1", "SGTA", "SH3BGRL3", "SH3GL1", "SH3GLB1", "SH3PXD2B", "SHCBP1", "SHMT1", "SHMT2", "SHOC2", "SIGMAR1", "SIL1", "SIN3A", "SKIV2L", "SKIV2L2", "SKP1", "SKP2", "SLC12A2", "SLC12A9", "SLC16A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A17", "SLC25A19", "SLC25A20", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A4", "SLC25A42", "SLC25A44", "SLC25A5", "SLC25A6", "SLC27A2", "SLC27A4", "SLC29A1", "SLC30A5", "SLC35A4", "SLC35B2", "SLC35F1", "SLC35F2", "SLC38A2", "SLC3A2", "SLC4A1AP", "SLC4A7", "SLC9A3R1", "SLFN11", "SLIRP", "SLIT2", "SLK", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC6", "SMCHD1", "SMN1*", "SMNDC1", "SMPD4", "SMU1", "SMYD3", "SND1", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPC", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNW1", "SNX1", "SNX2", "SNX27", "SNX3", "SNX5", "SNX6", "SNX9", "SOD2", "SON", "SORT1", "SPAG9", "SPART", "SPATA5", "SPATA5L1", "SPC25", "SPCS2", "SPEN", "SPNS1", "SPPL2A", "SPR", "SPTAN1", "SPTBN1", "SPTBN2", "SPTLC1", "SPTLC2", "SQLE", "SQSTM1", "SRCAP", "SREK1", "SRI", "SRM", "SRP14", "SRP54", "SRP68", "SRP72", "SRP9", "SRPK1", "SRPRA", "SRPRB", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF2", "SRSF3", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSNA1", "SSR1", "SSR4", "SSRP1", "STAG2", "STAM", "STAMBP", "STARD3", "STARD3NL", "STARD7", "STAT1", "STAT3", "STAU1", "STAU2", "STIP1", "STMN1", "STOM", "STOML2", "STRAP", "STRBP", "STT3A", "STT3B", "STUB1", "STX18", "STX4", "STX5", "STX7", "STX8", "STXBP3", "STXBP4", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGP2", "SUGT1", "SUN1", "SUPT16H", "SUPT5H", "SUPT6H", "SUPV3L1", "SURF4", "SURF6", "SUZ12", "SYAP1", "SYMPK", "SYNCRIP", "SYNE2", "SYNGR2", "SYS1", "TACC3", "TACO1", "TAF15", "TAF6L", "TAGLN2", "TALDO1", "TAMM41", "TARDBP", "TARS", "TARS2", "TBC1D13", "TBC1D15", "TBC1D4", "TBC1D9B", "TBCA", "TBCB", "TBCD", "TBCE", "TBL2", "TBL3", "TBRG4", "TCEA1", "TCERG1", "TCOF1", "TCP1", "TDP2", "TDRKH", "TECR", "TELO2", "TERF2IP", "TEX10", "TEX264", "TFAM", "TFCP2", "TFG", "TFRC", "THADA", "THOC1", "THOC2", "THOC3", "THOC6", "THOP1", "THRAP3", "THUMPD1", "THUMPD3", "THYN1", "TIAL1", "TIGAR", "TIMM13", "TIMM17A", "TIMM17B", "TIMM23", "TIMM44", "TIMM50", "TIMM8A", "TIMM8B", "TIMMDC1", "TIPRL", "TJP1", "TK1", "TKT", "TLCD1", "TLN1", "TM9SF3", "TM9SF4", "TMA7", "TMCO1", "TMED10", "TMED2", "TMED5", "TMED7", "TMED9", "TMEM109", "TMEM11", "TMEM126A", "TMEM14C", "TMEM160", "TMEM192", "TMEM199", "TMEM205", "TMEM209", "TMEM214", "TMEM230", "TMEM259", "TMEM33", "TMEM43", "TMEM65", "TMEM97", "TMOD3", "TMPO", "TMPO", "TMPPE", "TMSB4X", "TMTC3", "TMX1", "TMX2", "TMX4", "TNPO1", "TNPO3", "TOE1", "TOLLIP", "TOM1", "TOMM20", "TOMM22", "TOMM34", "TOMM40", "TOMM5", "TOMM70", "TOP1", "TOP2A", "TOP2B", "TOR1AIP1", "TOR1AIP2", "TOX4", "TP53", "TP53BP2", "TPD52", "TPD52L2", "TPI1", "TPM1", "TPM3", "TPM4", "TPP1", "TPP2", "TPR", "TPT1", "TPX2", "TRA2A", "TRA2B", "TRABD", "TRAF2", "TRAM1", "TRAP1", "TRAPPC11", "TRAPPC3", "TRAPPC4", "TRAPPC5", "TRIM21", "TRIM25", "TRIM28", "TRIM33", "TRIO", "TRIP12", "TRIP13", "TRMT10C", "TRMT1L", "TRMT6", "TROVE2", "TRUB1", "TSFM", "TSG101", "TSN", "TSNAX", "TSPAN3", "TSPAN6", "TSPO", "TSR1", "TTC1", "TTC19", "TTC26", "TTC37", "TTC38", "TTC4", "TTK", "TTLL12", "TTYH3", "TUBB", "TUBB2A", "TUBB2B", "TUBB4A", "TUBB4B", "TUBB6", "TUBGCP2", "TUBGCP3", "TUFM", "TWF1", "TWF2", "TXLNA", "TXLNG", "TXNDC12", "TXNDC17", "TXNDC5", "TXNDC9", "TXNL1", "TXNRD1", "TYMS", "U2AF2", "U2SURP", "UAP1", "UBA1", "UBA2", "UBA3", "UBA6", "UBAP2L", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2O", "UBE2Q1", "UBE2S", "UBE3C", "UBE4A", "UBR2", "UBR4", "UBR5", "UBR7", "UBTF", "UBXN7", "UCHL5", "UCK2", "UFC1", "UFD1", "UFL1", "UGCG", "UGDH", "UGGT1", "UGP2", "UHRF1", "UMPS", "UNC119B", "UNC45A", "UPF1", "UQCC2", "UQCR10", "UQCRC1", "UQCRC2", "UQCRQ", "URB1", "UROD", "USMG5", "USO1", "USP10", "USP11", "USP14", "USP24", "USP28", "USP34", "USP39", "USP47", "USP48", "USP5", "USP7", "USP8", "USP9X", "UTP14A", "UTP15", "UTP18", "UTP20", "UTP4", "UTP6", "UTRN", "VAMP7", "VANGL1", "VAPA", "VAPB", "VARS1", "VAT1", "VBP1", "VCL", "VCP", "VDAC1", "VDAC2", "VDAC3", "VIM", "VKORC1L1", "VMP1", "VPS16", "VPS18", "VPS26A", "VPS29", "VPS33B", "VPS35", "VPS4A", "VPS4B", "VPS51", "VPS53", "VRK1", "WAPL", "WARS", "WBP11", "WDHD1", "WDR1", "WDR12", "WDR18", "WDR3", "WDR33", "WDR36", "WDR4", "WDR41", "WDR43", "WDR5", "WDR6", "WDR61", "WDR75", "WDR77", "WDR91", "WFS1", "WIPI2", "WIZ", "WLS", "WTAP", "XAB2", "XPNPEP1", "XPNPEP3", "XPO1", "XPO4", "XPO5", "XPO7", "XPOT", "XRCC5", "XRCC6", "XRN2", "YARS", "YARS2", "YBX1", "YKT6", "YLPM1", "YME1L1", "YRDC", "YTHDC1", "YTHDC2", "YTHDF2", "YTHDF3", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2", "ZC3H11A", "ZC3H14", "ZC3H15", "ZC3H18", "ZC3H4", "ZC3HAV1", "ZCCHC11", "ZCCHC3", "ZCCHC8", "ZFR", "ZFYVE16", "ZMPSTE24", "ZMYM4", "ZNF280C", "ZNF318", "ZNF326", "ZNF638", "ZPR1", "ZW10", "ZYX"], "leading_proteins": ["ABHD10", "ACAT2", "ACOX1", "ACP2", "ADI1", "ADPGK", "AIFM1", "ALDH3A2", "ALDH9A1", "ALG12", "ANKLE2", "ANLN", "ANXA11", "APLP2", "APOL2", "APOO", "ARL6IP1", "ARV1", "ASNA1", "ATP1B1", "ATP5F1", "ATP6AP2", "ATP6V0A1", "ATP6V0A2", "ATP7B", "B4GAT1", "BAG5", "BAG6", "BAIAP2", "BSG", "C19orf70", "C1QBP", "CALU", "CCDC47", "CERS2", "CHST14", "CIRBP", "CLN5", "CLPP", "CLPTM1", "CLPTM1L", "CLUH", "CNNM4", "CNOT4", "COL4A3BP", "COLEC12", "COMT", "COQ3", "CPD", "CPVL", "CRK", "CRTAP", "CSGALNACT2", "CTBS", "CXADR", "CYB5B", "DERL1", "DHCR24", "DIAPH2", "DNASE2", "DNM1L", "DR1", "DSC3", "DSG2", "DUSP9", "EHD1", "EHD4", "EIF2S1", "EIF3L", "EIF5", "ELP3", "EMD", "EPDR1", "ERGIC3", "ERLIN1", "EWSR1", "EXO1", "FAM8A1", "FIS1", "FKBP14", "FKBP7", "FLOT1", "FLOT2", "FMR1", "FN3KRP", "FOXRED1", "FUS", "FXR1", "FXR2", "GAA", "GALNT1", "GHITM", "GLA", "GLG1", "GLUD1", "GM2A", "GNAI2", "GNS", "GOLIM4", "GPAM", "HADH", "HIF1AN", "HLA-A", "HLA-B", "HLA-C", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPR", "HSD17B11", "HSD17B12", "HSPA13", "IDH2", "IPO7", "IPO8", "IRS4", "IST1", "ITM2C", "KCTD5", "KDELR1", "KDM1B", "KDSR", "KHSRP", "KIAA0319L", "KIF23", "KIFBP", "LAMP1", "LBR", "LDAH", "LGALS3BP", "LPCAT3", 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https://git-lfs.github.com/spec/v1 +oid sha256:bf8c178bd376d61e3d662c8b4991b6209bbe1bacb035f23278b8dd23acf61c92 +size 133362 diff --git a/protein_atlas_biological_process/consensus.joblib b/protein_atlas_biological_process/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..349f8d27a86f572737f56add133f9608f8d44634 --- /dev/null +++ b/protein_atlas_biological_process/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:38341cef69e6a6bd35576650363bb44488dbbf553e58a3edd560a4fc8dd29586 +size 63801 diff --git a/protein_atlas_biological_process/df_merge.tsv b/protein_atlas_biological_process/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..8e5c9aef264435bdf7bdfcfa2721b4e9e40ac26b --- /dev/null +++ b/protein_atlas_biological_process/df_merge.tsv @@ -0,0 +1,10 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Sphingolipid metabolism 8 10 2.695131640893662 0.0070360827001176 5.075242718446602 9.720873786407768 1.0723891387155546 0.1672146303539832 2.245095774833478 1.0461446620678432 1.744521381224598 0.248179764200939 0.0001394367354527 0.0875404472016038 0.0007461625149634 3.960684957731953e-06 8.18607400016366e-08 +Adaptive immunity 5 10 2.420843031768495 0.015484561983069 4.143203883495145 13.968446601941748 0.5718686468442667 0.5057512333092327 1.8737785476971824 1.931213842986535 0.8618291696256006 0.3181645561745452 0.1951348675565694 0.2370066357192962 0.1009015630926116 0.0112051302851985 0.0526960840113874 +Sterol metabolism 10 22 2.1930975487174207 0.0283003516049118 7.606796116504855 25.203883495145632 1.1785484151208083 0.2872927387372206 3.1377365577760563 3.096691699470945 1.2399567569518877 0.3064799172119154 0.0006238845233945 0.0221752921752284 0.0011293669878184 1.8258974525424897e-06 2.808936189230378e-07 +Lipid transport 6 19 2.1875285902849027 0.0287039584315802 5.140776699029126 21.796116504854368 0.7022879686929654 0.35525802853007 2.5598823127228028 3.5727100026626353 1.209238263022456 0.2984698606617377 0.0682744848928598 0.0388410242837302 0.1290920553826253 0.0047615333276254 0.0038884735347153 +Respiratory chain 6 26 2.181944710570971 0.0291136135111522 10.895631067961164 31.91990291262136 1.1075564231308468 0.3095707256998049 4.44287149555612 3.6670789399383112 1.4970961025113558 0.3356221172021658 0.5912243116359891 1.0 1.0 0.0034676048515423 0.008809974318292 +Cholesterol metabolism 7 19 2.15175514447913 0.0314166443954153 7.111650485436893 23.79854368932039 1.169709264926864 0.2871268807807383 2.8890755390042298 2.7173834172675666 1.205315163774447 0.3061468445376054 0.0004609575392824 0.0196403757049561 0.0008840144918394 1.0512375529822254e-05 4.480952963287816e-05 +Steroid metabolism 10 23 2.078503070312619 0.0376630484057241 7.703883495145631 26.439320388349515 1.128083592407629 0.3052190273048834 3.279782799169419 3.1412859163137186 1.216134343451914 0.3162944576553002 0.0011685479247103 0.0285808600856777 0.0018806372047711 5.971130761304056e-06 1.5467521072121866e-06 +Amino-acid transport 5 7 2.02345543550259 0.0430262137420323 3.063106796116505 7.016990291262136 0.9299828460487652 0.271909550896337 1.9171930478617292 1.3907470472448622 1.1684874391815692 0.271335812648974 0.345983072001316 1.0 0.2445730022705269 0.5094216597603356 0.0022975467393054 +Symport 5 6 1.974595635913016 0.0483140547121039 2.844660194174758 6.961165048543689 0.6469017708869542 0.3932450371351912 1.8940749800794765 1.272733699501336 1.0491712043829624 0.3136298512602674 1.0 1.0 1.0 0.5661975770404395 0.0053005354814706 diff --git a/protein_atlas_biological_process/metrics.json b/protein_atlas_biological_process/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..60b7dab776681d1c77add1e26633aae82955a013 --- /dev/null +++ b/protein_atlas_biological_process/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2644, + "annotations_size": 165, + "title": "Average number of proteins per term", + "value": 26.472727272727273 +} \ No newline at end of file diff --git a/protein_atlas_biological_process/paths.json b/protein_atlas_biological_process/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..ac580c596e80fb43cfcd9423548716aabf201fcc --- /dev/null +++ b/protein_atlas_biological_process/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/protein_atlas_biological_process/fragment/C197/C197_val_log2fc"} \ No newline at end of file diff --git a/protein_atlas_biological_process/result.tsv b/protein_atlas_biological_process/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..0e9bfb11d69d1a84946021c5323696d386b03fc6 --- /dev/null +++ b/protein_atlas_biological_process/result.tsv @@ -0,0 +1,54 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Sphingolipid metabolism 0.8476578128285388 2.695131640893662 0.0070360827001176 0.688095175801675 0.5203353573683943 10 Q13510,P04062,O15269,P07602,Q06136,Q16739,O95470,P17900 8 +Adaptive immunity 0.7896431595530303 2.420843031768495 0.015484561983069 0.9238416453151296 0.5203353573683943 10 P01889,Q96FW1,P04439,Q07021,P10321 5 +Sterol metabolism 0.6389204195287802 2.1930975487174207 0.0283003516049118 0.9912342814720416 0.5203353573683943 22 P04062,P61916,O75477,O75845,Q15392,Q16850,Q14739,Q9H2C2,O15118,Q9UBM7 10 +Lipid transport 0.638770593381842 2.1875285902849027 0.0287039584315802 0.991815029778143 0.5203353573683943 19 Q9Y5P4,P61916,Q9BQE5,Q99720,Q9H2C2,O15118 6 +Respiratory chain 0.6344715063092261 2.181944710570971 0.0291136135111522 0.9923653715074578 0.5203353573683943 26 O14949,Q96CU9,O75306,Q9UDW1,O43676,Q6DKK2 6 +Cholesterol metabolism 0.6327844338366254 2.15175514447913 0.0314166443954153 0.994840527672918 0.5203353573683943 19 P04062,P61916,Q15392,Q16850,Q14739,O15118,Q9UBM7 7 +Steroid metabolism 0.6197819492973528 2.078503070312619 0.0376630484057241 0.9982258851178027 0.5203353573683943 23 P04062,P61916,O75477,O75845,Q15392,Q16850,Q14739,Q9H2C2,O15118,Q9UBM7 10 +Amino-acid transport 0.8062419546213414 2.02345543550259 0.0430262137420323 0.9992944840048918 0.5203353573683943 7 Q6P4A7,Q15758,Q96QD8,P08195,Q96H78 5 +Symport 0.8267626990143983 1.9745956359130157 0.0483140547121039 0.9997172170804096 0.5203353573683943 6 P55011,P53985,Q00325,Q9Y6M7,Q96QD8 5 +Sodium transport 0.8135155421577712 1.91932640313754 0.0549430385681155 0.9999107583454824 0.5203353573683943 6 P05026,P55011,Q9Y6M7,Q96QD8 4 +Steroid biosynthesis 0.5912087886362936 1.900493734168444 0.0573683564768892 0.999941597368372 0.5203353573683943 18 Q53GQ0,Q8NBQ5,O75845,Q15392,Q16850,Q14739,P37268,Q9UKR5,P48449,Q9UBM7 10 +Ion transport 0.5392948427156055 1.8585483234562403 0.0630911877597251 0.9999786175027028 0.5203353573683943 50 P21796,Q9C0H2,P51798,P55011,P45880,P51790,P61421,P16615,Q93050,P35670,O75964,P05026,P24539,Q6P4Q7,Q8TAD4,Q9Y277,Q9Y487,P05023,Q96S66,Q9Y6M7,Q96QD8,Q15904,Q9H0H5 23 +Immunity 0.4763536349425068 1.8189963464860248 0.0689119874747634 0.9999923533480962 0.5203353573683943 65 P01889,O00584,Q96PK6,Q96FW1,Q13501,P04439,Q7Z434,Q07021,Q9Y5A9,P10321,Q9NUD5,Q8IV08,P46379,Q9UQ84,Q9NZ08 15 +Lipid degradation 0.6291640562823761 1.8112643691567285 0.0700999383683345 0.9999938057943244 0.5203353573683943 12 Q8NHP8,Q8NCC3,Q9H6V9,Q8N2A8 4 +Potassium transport 0.8105784904274784 1.7093909548419066 0.0873785552833747 0.9999997194821636 0.5203353573683943 4 P05026,P55011 2 +Antiport 0.75398028809703 1.6670778143291685 0.0954989329817821 0.999999935805358 0.5203353573683943 6 P12235,P12236,P51798,P05141,P51790 5 +Notch signaling pathway 0.7522031869828073 1.6180825205935698 0.1056448149353599 0.9999999900194422 0.5203353573683943 5 P05067 1 +Sterol biosynthesis 0.5664430987736584 1.5449314176605349 0.1223628531029907 0.9999999995564174 0.5203353573683943 14 Q16850,Q9UBM7,O75845,Q15392 4 +Cholesterol biosynthesis 0.5842064331937125 1.5153662347218957 0.129679683285532 0.9999999998885564 0.5203353573683943 11 Q16850,Q9UBM7,Q15392 3 +Glyoxylate bypass 0.9447388342165024 1.5109259674550393 0.1308073139958663 0.9999999999100192 0.5203353573683943 2 P48735 1 +Prostaglandin metabolism 0.8099204846648964 1.3899126016490269 0.1645554184905986 0.9999999999998692 0.5596738589907623 3 Q9H7Z7,Q14914 2 +Sodium/potassium transport 0.8087684274536028 1.3852618685587983 0.1659724088750227 0.9999999999999012 0.5596738589907623 3 P05026 1 +Cell adhesion 0.5077086477515359 1.355814773933672 0.1751581094249454 0.999999999999984 0.5780217611023201 24 P05026,Q14126,P05067,Q14574,O00592,Q96GC9,Q08380 7 +Electron transport 0.494170482406136 1.313558584327286 0.1889947937543643 0.999999999999999 0.5845596847711702 38 O96000,O14949,Q96CU9,O75306,Q9UDW1,O43676,O43169,Q6DKK2 8 +Unfolded protein response 0.6478044026215296 1.3131615392100382 0.1891285208663622 0.999999999999999 0.5845596847711702 7 Q15629,Q9BUN8 2 +Osteogenesis 0.894776684330051 1.3067122924110663 0.1913104422887466 0.9999999999999994 0.5845596847711702 2 Q99523 1 +Leukotriene biosynthesis 0.8849356548069647 1.266676916660426 0.205270837092768 1.0 0.6158125112783042 2 P09960 1 +Lipid metabolism 0.4213862235676689 1.2263151104102124 0.2200801172365014 1.0 0.6370740235793463 112 Q8NHP8,Q13510,Q16836,Q9H7Z7,Q8NBQ5,P07602,Q16850,P09960,Q96G23,Q9H6V9,Q9HCL2,P35790,Q8N2A8,O14975,P61916,O15269,O75845,O75477,Q14739,Q99735,Q16739,Q9UKR5,Q6P1A2,P48449,Q9UBM7,P04062,Q96N66,Q8NCC3,Q15392,Q9H2C2,P17900,P23786,P38571,Q15067,Q06136,O15118 36 +Phospholipid metabolism 0.4846716643193968 1.0522845708210573 0.2926690084016417 1.0 0.7162217098082964 14 P35790,Q92604,Q96N66,Q6P1A2,Q9NPH0,Q9HCL2 6 +Prostaglandin biosynthesis 0.8096139288417843 0.965237813283679 0.3344257113347031 1.0 0.7162217098082964 2 Q9H7Z7 1 +Hydrogen ion transport 0.4469912204574576 0.9565718324862186 0.3387834116849499 1.0 0.7162217098082964 21 Q93050,Q9Y487,O75964 3 +Phospholipid biosynthesis 0.4655402658724948 0.899884648655579 0.3681816404625671 1.0 0.7162217098082964 13 P35790,Q92604,Q96N66,Q6P1A2,Q9HCL2 5 +Sensory transduction 0.558212838405111 0.8988225747058673 0.3687471736670256 1.0 0.7162217098082964 7 P50897,Q6P4Q7 2 +Vision 0.558212838405111 0.8988225747058673 0.3687471736670256 1.0 0.7162217098082964 7 P50897,Q6P4Q7 2 +Oogenesis 0.6099288174791846 0.8722212608032586 0.3830876830844427 1.0 0.7162217098082964 4 Q9Y5A9 1 +Translocation 0.4261452566760976 0.8663000305631298 0.3863256495329599 1.0 0.7162217098082964 46 Q99595,Q15629,Q9NS69,O60830 4 +Lipid biosynthesis 0.4085505647605089 0.7450845895475988 0.4562205845694673 1.0 0.7953377541313207 48 P35790,Q96N66,Q9H7Z7,Q8NBQ5,O75845,Q15392,Q16850,Q14739,Q9UKR5,Q16739,Q96G23,Q6P1A2,P48449,Q9UBM7,Q9HCL2 15 +Exocytosis 0.4147126873965935 0.5706320520638215 0.5682490868895287 1.0 0.907312568480179 12 P11233,P51809 2 +Innate immunity 0.3741919275972644 0.5183759489854058 0.6041959919334914 1.0 0.907312568480179 53 P01889,O00584,Q96PK6,P04439,Q07021,Q7Z434,Q9Y5A9,P10321,Q9NUD5 9 +Spermatogenesis 0.3780332613169913 0.4949653830193175 0.6206245563035413 1.0 0.907312568480179 21 Q8N2A8,Q08J23,Q9H8Y8,Q16181,Q9Y5A9,Q9Y2W6,P46379,Q9H0H5 8 +Apoptosis 0.3394353492913553 0.4527061233285745 0.6507603697050115 1.0 0.917738982917324 98 Q9H3K2,O95831,Q15375,O14737,P05067,Q13501,P21796,Q9H2J4,O00115,Q15041,Q9H8M7,Q9UHX1,Q9Y3D6,Q96A26,P46379,O95470,Q01085,Q96KA5,O95197,Q07021,Q03164,O95140,Q9NZJ7 23 +Endocytosis 0.3574256017753582 0.3102958402340622 0.7563359941675225 1.0 0.9946479942754156 28 Q99523,P05067 2 +Tricarboxylic acid cycle 0.3373649439235366 0.2674302121456313 0.7891379403200813 1.0 0.9946479942754156 18 O75874,P48735 2 +Ubiquinone biosynthesis 0.4921453565098129 0.2611831886573765 0.793951241801718 1.0 0.9946479942754156 3 Q9NZJ6 1 +Phagocytosis 0.4808784551306278 0.2355436043168292 0.8137868393257597 1.0 0.9946479942754156 3 Q96JJ3,P50570 2 +Proline biosynthesis 0.4577811435062363 0.1882606147737116 0.8506723581282558 1.0 0.9946479942754156 3 Q96C36,P32322 2 +Angiogenesis 0.3395789695651462 0.1694028038999866 0.8654798181873977 1.0 0.9946479942754156 12 Q9H2J4,P35613 2 +Tetrahydrobiopterin biosynthesis 0.5321725965177835 0.1476528498325853 0.8826167440369266 1.0 0.9974778271650198 2 P09417 1 +Neurogenesis 0.3344301157569708 0.1155777117089112 0.907987227985794 1.0 1.0 41 O14786,P55209,Q9H9T3,Q15375,O94813,Q16637,Q8WUJ1,Q14012,Q96EK5,Q7L576,Q12824,Q06787 12 +Branched-chain amino acid catabolism 0.4602573807721326 0.0736543650225769 0.9412854115418804 1.0 1.0 2 Q6NVY1 1 +Nucleotide metabolism 0.3397709602063687 0.0591253558406441 0.9528522629255438 1.0 1.0 8 Q9Y5B8,Q969T7 2 +Glycogen biosynthesis 0.4212717638152801 0.0543490610835556 0.9566570621928996 1.0 1.0 2 P31751 1 +Growth regulation 0.3275142314990555 0.0454856551397773 0.963720208604882 1.0 1.0 9 Q99816,Q8N2F6,Q15014,Q9Y230,P63244,O96019,Q9Y265,Q13177 8 diff --git a/protein_atlas_biological_process/selections.json b/protein_atlas_biological_process/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..9b02021b4a87e829d44ff083cb7b6a09f8137a42 --- /dev/null +++ b/protein_atlas_biological_process/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["ATP synthesis", "Adaptive immunity", "Amino-acid biosynthesis", "Amino-acid transport", "Angiogenesis", "Antiport", "Antiviral defense", "Apoptosis", "Aromatic hydrocarbons catabolism", "Asparagine biosynthesis", "Autophagy", "B-cell activation", "Behavior", "Biological rhythms", "Biomineralization", "Branched-chain amino acid catabolism", "Calcium transport", "Carbohydrate metabolism", "Catecholamine metabolism", "Cell adhesion", "Cell cycle", "Cell division", "Cell shape", "Chemotaxis", "Cholesterol biosynthesis", "Cholesterol metabolism", "Chromosome partition", "Cilium biogenesis/degradation", "Coenzyme A biosynthesis", "Collagen degradation", "Complement pathway", "Copper transport", "Cysteine biosynthesis", "DNA condensation", "DNA damage", "DNA excision", "DNA recombination", "DNA repair", "DNA replication", "DNA synthesis", "Detoxification", "Differentiation", "ER-Golgi transport", "Electron transport", "Endocytosis", "Erythrocyte maturation", "Exocytosis", "Fatty acid biosynthesis", "Fatty acid metabolism", "Fertilization", "GMP biosynthesis", "GPI-anchor biosynthesis", "Galactose metabolism", "Gastrulation", "Gluconate utilization", "Gluconeogenesis", "Glucose metabolism", "Glutathione biosynthesis", "Glycogen biosynthesis", "Glycogen metabolism", "Glycolysis", "Glyoxylate bypass", "Growth arrest", "Growth regulation", "Hearing", "Heme biosynthesis", "Host-virus interaction", "Hydrogen ion transport", "Hypusine biosynthesis", "Immunity", "Inflammatory response", "Inhibition of host STAT1 by virus", "Inhibition of host STAT2 by virus", "Inhibition of host innate immune response by virus", "Inhibition of host interferon signaling pathway by virus", "Innate immunity", "Inositol biosynthesis", "Ion transport", "Isoprene biosynthesis", "Keratinization", "Leukotriene biosynthesis", "Lipid biosynthesis", "Lipid degradation", "Lipid metabolism", "Lipid transport", "Meiosis", "Melanin biosynthesis", "Methionine biosynthesis", "Methotrexate resistance", "Mitosis", "Myogenesis", "Necrosis", "Neurogenesis", "Neurotransmitter degradation", "Neurotransmitter transport", "Nonsense-mediated mRNA decay", "Notch signaling pathway", "Nucleotide biosynthesis", "Nucleotide metabolism", "One-carbon metabolism", "Oogenesis", "Osteogenesis", "Pentose shunt", "Peroxisome biogenesis", "Phagocytosis", "Phenylalanine catabolism", "Phospholipid biosynthesis", "Phospholipid metabolism", "Plasminogen activation", "Polyamine biosynthesis", "Porphyrin biosynthesis", "Potassium transport", "Proline biosynthesis", "Prostaglandin biosynthesis", "Prostaglandin metabolism", "Protein biosynthesis", "Protein transport", "Purine biosynthesis", "Purine salvage", "Pyridine nucleotide biosynthesis", "Pyrimidine biosynthesis", "RNA-mediated gene silencing", "Respiratory chain", "Ribosome biogenesis", "Sensory transduction", "Serine biosynthesis", "Sexual differentiation", "Sodium transport", "Sodium/potassium transport", "Spermatogenesis", "Spermidine biosynthesis", "Sphingolipid metabolism", "Steroid biosynthesis", "Steroid metabolism", "Sterol biosynthesis", "Sterol metabolism", "Stress response", "Sugar transport", "Symport", "Tetrahydrobiopterin biosynthesis", "Transcription", "Transcription regulation", "Transcription termination", "Translation regulation", "Translocation", "Transport", "Tricarboxylic acid cycle", "Tyrosine catabolism", "Ubiquinone biosynthesis", "Ubl conjugation pathway", "Unfolded protein response", "Viral RNA replication", "Viral immunoevasion", "Viral penetration into host nucleus", "Virus entry into host cell", "Vision", "Wnt signaling pathway", "Xylose metabolism", "Zinc transport", "mRNA capping", "mRNA processing", "mRNA splicing", "mRNA transport", "rRNA processing", "tRNA processing"], "available_proteins": ["AAAS", "AAMP", "AARS", "AARS2", "ABCB1", "ABCB7", "ABCD3", "ABCE1", "ABCF3", "ABHD12", "ABHD6", "ABI1", "ABRAXAS2", "ACAA2", "ACACA", "ACACB", "ACADM", "ACADSB", "ACADVL", "ACAT1", "ACBD3", "ACIN1", "ACLY", "ACO2", "ACOT7", "ACOX1", "ACOX3", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN4", "ACTR3", "ADAR", "ADI1", "ADK", "ADNP", "ADPGK", "ADPRHL2", "ADSL", "ADSS", "AFDN", "AGL", "AGPAT1", "AGPS", "AHCY", "AHCYL1", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AKAP17A", "AKAP8", "AKAP8L", "AKT2", "ALDH18A1", "ALDH3A2", "ALDOA", "ALDOC", "ALKBH5", "ANAPC1", "ANAPC10", "ANAPC5", "ANAPC7", "ANKLE2", "ANKRD17", "ANLN", "ANP32A", "ANP32B", "ANXA1", "ANXA11", "ANXA2", "AP1B1", "AP1G1", "AP1M1", "AP1S2", "AP2A1", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "APEX1", "APEX2", "API5", "APOL2", "APOO", "APP", "APRT", "AQR", "ARCN1", "ARF4", "ARFGAP1", "ARFGAP2", "ARFIP2", "ARHGEF2", "ARID1A", "ARID3B", "ARIH1", "ARIH2", "ARL2", "ARL3", "ARL6IP1", "ARMC10", "ARMT1", "ARV1", "ASAH1", "ASCC2", "ASCC3", "ASH2L", "ASNA1", "ASNS", "ATG3", "ATIC", "ATP13A1", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2C1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1D", "ATP6V1E1", "ATP6V1G1", "ATP6V1H", "ATP7B", "AUP1", "AURKA", "BAG3", "BAG6", "BANF1", "BAZ1A", "BAZ1B", "BCAP31", "BCAS3", "BCCIP", "BCLAF1", "BICD2", "BIRC6", "BMS1", "BOP1", "BPTF", "BRAP", "BRAT1", "BRD1", "BRD2", "BRIX1", "BSG", "BTF3", "BUB1B", "BUB3", "BUD23", "BUD31", "BYSL", "BZW1", "BZW2", "C1QBP", "CACUL1", "CACYBP", "CAD", "CALCOCO1", "CAMK1", "CAMK2G", "CAND1", "CAND2", "CANX", "CAPRIN1", "CARM1", "CARS", "CBL", "CBX2", "CBX3", "CBX5", "CCAR1", "CCAR2", "CCDC124", "CCDC22", "CCDC86", "CCNB1", "CCNB2", "CD2AP", "CDC123", "CDC20", "CDC23", "CDC25C", "CDC27", "CDC34", "CDC40", "CDC42", "CDC5L", "CDC73", "CDCA8", "CDK1", "CDK2", "CDK4", "CDK5", "CDK5RAP3", "CDK6", "CDX2", "CEBPZ", "CENPF", "CEP55", "CEPT1", "CERS2", "CETN2", "CFL1", "CHAF1A", "CHAF1B", "CHCHD3", "CHD4", "CHID1", "CHKA", "CHM", "CHMP2A", "CHMP2B", "CHMP7", "CHORDC1", "CHST14", "CIAPIN1", "CIRBP", "CISD2", "CKAP2", "CKAP5", "CLASP1", "CLASP2", "CLCC1", "CLCN3", "CLCN7", "CLIC1", "CLIC4", "CLINT1", "CLIP1", "CLPTM1", "CLPTM1L", "CLTC", "CMPK1", "CMTR1", "CNNM4", "CNOT1", "CNOT2", "CNOT3", "CNOT4", "CNOT7", "CNOT9", "COL4A3BP", "COMMD2", "COMT", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS6", "COPS7A", "COPS7B", "COPZ1", "COQ3", "COQ8A", "COQ9", "CORO7", "COX2", "CPNE1", "CPOX", "CPSF1", "CPSF3", "CPSF6", "CPSF7", "CPT2", "CRNKL1", "CS", "CSE1L", "CSK", "CSNK1A1", "CSNK2A1", "CSNK2A2", "CSNK2B", "CSTF1", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTH", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTPS2", "CTTN", "CTU2", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CXADR", "CYB5B", "CYB5D2", "CYB5R1", "CYB5R3", "CYC1", "CYFIP1", "CYP51A1", "DAP3", "DARS", "DARS2", "DAZAP1", "DBN1", "DBNL", "DCAF1", "DCAF7", "DCPS", "DCTN1", "DCTN3", "DCXR", "DDB1", "DDRGK1", "DDT", "DDX1", "DDX17", "DDX20", "DDX21", "DDX23", "DDX39B", "DDX3X", "DDX41", "DDX46", "DDX47", "DDX5", "DDX51", "DDX54", "DDX56", "DENR", "DERL1", "DFFA", "DHCR24", "DHCR7", "DHFR", "DHX15", "DHX16", "DHX29", "DHX30", "DHX36", "DHX8", "DHX9", "DIABLO", "DIAPH1", "DIAPH2", "DIDO1", "DIMT1", "DIS3", "DKC1", "DLAT", "DLST", "DNA2", "DNAAF5", "DNAJA3", "DNAJB1", "DNAJC2", "DNAJC3", "DNASE2", "DNM1L", "DNM2", "DNMT1", "DNPH1", "DNTTIP2", "DOCK7", "DOHH", "DPY30", "DPYSL2", "DR1", "DSC1", "DSC3", "DSG2", "DST", "DTYMK", "DUT", "DYNC1H1", "DYNC1LI1", "DYNC1LI2", "DYNC2H1", "DYNLL1", "EBNA1BP2", "ECD", "ECH1", "ECHS1", "ECI1", "ECSIT", "EDF1", "EDRF1", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EFL1", "EFTUD2", "EHD1", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2D", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A3", "EIF4B", "EIF4E", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "ELAC2", "ELMO2", "ELMOD2", "ELOA", "ELOB", "ELOC", "ELP1", "ELP2", "ELP3", "ELP4", "EMG1", "ENO1", "ENO2", "ENSA", "EPB41", "EPB41L2", "EPHA7", "EPHX1", "EPHX2", "EPRS", "EPS15", "EPS15L1", "ERAL1", "ERAP1", "ERCC2", "ERG28", "ERGIC3", "ERH", "ERI1", "ERLIN1", "ERLIN2", "ERO1A", "ESF1", "ESYT1", "ETF1", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXO1", "EXOC2", "EXOC3", "EXOC5", "EXOC7", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "EZR", "FAF1", "FAF2", "FAH", "FAM162A", "FAM208A", "FANCI", "FAR1", "FARSA", "FARSB", "FASN", "FBL", "FBXO22", "FBXO7", "FDFT1", "FDPS", "FECH", "FEN1", "FGFR1OP", "FH", "FIP1L1", "FIS1", "FKBP8", "FLII", "FLNA", "FLNB", "FLOT2", "FMR1", "FOXRED1", "FRG1", "FTSJ3", "FUBP1", "FUBP3", "FXR1", "G3BP1", "G3BP2", "G6PD", "GABARAPL2", "GADD45GIP1", "GAK", "GALK1", "GALM", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GBA", "GBF1", "GCFC2", "GCLC", "GCLM", "GCN1", "GEMIN4", "GEMIN5", "GET4", "GFM1", "GFPT1", "GGNBP2", "GHITM", "GINS3", "GINS4", "GLRX", "GM2A", "GMPS", "GNAI1", "GNAI2", "GNAI3", "GNL2", "GNL3L", "GNPDA1", "GOLIM4", "GOLT1B", "GOPC", "GORASP2", "GOT1", "GOT2", "GPAM", "GPI", "GPKOW", "GRB2", "GRIPAP1", "GRSF1", "GRWD1", "GSK3B", "GSPT1", "GSS", "GSTZ1", "GTF2I", "GTF3C1", "GTF3C2", "GTF3C3", "GTF3C4", "GTPBP10", "GTPBP3", "GTPBP4", "GUF1", "H2AFX", "HACD3", "HACL1", "HADH", "HADHA", "HADHB", "HAUS3", "HAUS5", "HAUS8", "HBS1L", "HCFC1", "HDAC2", "HDGF", "HDLBP", "HEATR1", "HECTD1", "HECTD3", "HELLS", "HIBADH", "HIBCH", "HIF1AN", "HIGD2A", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLTF", "HMBS", "HMCES", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMGCS1", "HMOX1", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH3", "HNRNPK", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HPF1", "HPRT1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSP90AA1", "HSP90AB1", "HSPA1B", "HSPA4", "HSPA4L", "HSPA8", "HSPB1", "HSPD1", "HSPE1", "HSPH1", "HTATIP2", "HUWE1", "HYOU1", "IARS", "IARS2", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDI1", "IFT27", "IGBP1", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IK", "ILF2", "ILF3", "ILVBL", "IMP4", "IMPACT", "IMPDH1", "IMPDH2", "INA", "INCENP", "INTS7", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IST1", "ISYNA1", "ITGB1", "ITPA", "IVD", "JUP", "KARS", "KCTD5", "KDELR1", "KDM1A", "KDM1B", "KDM3B", "KDSR", "KHDRBS1", "KHSRP", "KIAA0319L", "KIAA0391", "KIF11", "KIF18B", "KIF20A", "KIF23", "KIF2A", "KIF2C", "KIFBP", "KIFC1", "KLC1", "KMT2A", "KNTC1", "KPNA1", "KPNA2", "KPNA3", "KPNB1", "KRR1", "LAMP1", "LARP1", "LARP4", "LARP4B", "LARS", "LARS2", "LAS1L", "LASP1", "LBR", "LCLAT1", "LDAH", "LETM1", "LGALS3", "LGALS3BP", "LIG1", "LIG3", "LIMA1", "LIPA", "LLGL1", "LMAN1", "LMAN2", "LPCAT1", "LPCAT3", "LPGAT1", "LRPPRC", "LRWD1", "LSM14B", "LSM2", "LSM6", "LSM7", "LSS", "LTA4H", "LTN1", "LUC7L3", "LYAR", "LYPLA1", "M6PR", "MACF1", "MAD2L1", "MANF", "MAP1S", "MAPK1", "MAPRE1", "MAPRE2", "MARS", "MAT2A", "MAT2B", "MATR3", "MAVS", "MBD3", "MBOAT7", "MCAT", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCMBP", "MCU", "MDC1", "MDH1", "MDH2", "MECP2", "MED1", "MED21", "MED23", "MED24", "MED25", "MED4", "MFN2", "MFSD10", "MFSD3", "MFSD5", "MGEA5", "MGST2", "MICU1", "MID1", "MIF", "MINDY3", "MKI67", "MKRN2", "MLEC", "MMGT1", "MMS19", "MORF4L1", "MORF4L2", "MOSPD2", "MOV10", "MPC2", "MPHOSPH10", "MPHOSPH6", "MRE11", "MRPS27", "MRTO4", "MSH2", "MSH3", "MSH6", "MSN", "MTA1", "MTAP", "MTBP", "MTCH1", "MTCH2", "MTHFD1L", "MTHFD2", "MTMR2", "MTMR6", "MTOR", "MTPAP", "MTR", "MTX1", "MTX2", "MVK", "MYBBP1A", "MYCBP", "MYDGF", "MYH10", "MYH14", "MYH9", "MYO1C", "MYO1D", "MYO6", "NAA15", "NAE1", "NAF1", "NAMPT", "NAP1L1", "NAPA", "NAPG", "NARS", "NASP", "NAT10", "NAXE", "NBN", "NCAPD2", "NCAPG", "NCAPH", "NCBP1", "NCKAP1", "NCOA5", "NCSTN", "NDC1", "NDUFA10", "NDUFA3", "NDUFA4", "NDUFA5", "NDUFA7", "NDUFA9", "NDUFAF4", "NDUFB10", "NDUFB3", "NDUFB4", "NDUFB5", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS6", "NDUFS7", "NDUFV1", "NDUFV2", "NECAP1", "NECAP2", "NEK9", "NELFA", "NELFCD", "NELFE", "NES", "NHP2", "NIPBL", "NKRF", "NLE1", "NMD3", "NME1", "NME6", "NME7", "NOC2L", "NOL11", "NOL9", "NONO", "NOP14", "NOP2", "NOP53", "NOP56", "NOP58", "NOSIP", "NPC1", "NPC2", "NPLOC4", "NPM1", "NRP1", "NSA2", "NSD2", "NSDHL", "NSF", "NSUN2", "NSUN5", "NT5C2", "NT5C3B", "NTHL1", "NUBP2", "NUCKS1", "NUDC", "NUDT21", "NUF2", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP160", "NUP188", "NUP205", "NUP210", "NUP214", "NUP37", "NUP43", "NUP50", "NUP54", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NUPL2", "NVL", "NXF1", "NXN", "OCRL", "OGDH", "OGT", "OPA1", "OPA3", "OSBP", "OSBPL8", "OSBPL9", "OSGEP", "OTUB1", "OTULIN", "PA2G4", "PABPC1", "PABPN1", "PACSIN2", "PAF1", "PAFAH1B1", "PAFAH1B2", "PAFAH1B3", "PAICS", "PAK1", "PAK1IP1", "PAK2", "PANK4", "PAPOLA", "PARK7", "PARN", "PARP1", "PBRM1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCK2", "PCLAF", "PCM1", "PCNA", "PCNP", "PDCD11", "PDCD4", "PDCD5", "PDCD6", "PDCD6IP", "PDCL3", "PDE12", "PDE6D", "PDHA1", "PDHB", "PDK1", "PDK3", "PDLIM7", "PDS5A", "PDS5B", "PECR", "PELO", "PELP1", "PEPD", "PES1", "PEX14", "PEX19", "PFAS", "PFKL", "PFKM", "PFKP", "PGAM1", "PGAM5", "PGD", "PGK1", "PGM1", "PGM2", "PGM3", "PGP", "PHB", "PHB2", "PHF5A", "PHF6", "PHF8", "PHGDH", "PHKA1", "PICALM", "PIGT", "PIH1D1", "PIK3C2A", "PIN1", "PIR", "PISD", "PITHD1", "PITPNB", "PKM", "PKMYT1", "PKN2", "PLA2G15", "PLAA", "PLBD2", "PLCG1", "PLD3", "PLD6", "PLIN3", "PLK1", "PLRG1", "PNN", "PNP", "PNPT1", "PODXL", "POGZ", "POLA1", "POLA2", "POLD1", "POLD2", "POLD3", "POLDIP2", "POLDIP3", "POLE", "POLR1A", "POLR1B", "POLR1E", "POLR2B", "POLR2C", "POLR2G", "POLR3A", "POLR3C", "POLRMT", "POP1", "PPAT", "PPHLN1", "PPID", "PPIF", "PPIH", "PPP1CA", "PPP1CB", "PPP2R1A", "PPP5C", "PPP6C", "PPT1", "PQBP1", "PRAF2", "PRCC", "PRDX6", "PREB", "PRIM1", "PRIM2", "PRKAG1", "PRKCD", "PRKDC", "PRKRA", "PRMT5", "PRPF19", "PRPF3", "PRPF31", "PRPF38B", "PRPF39", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPS1", "PRPSAP1", "PRPSAP2", "PSAP", "PSAT1", "PSIP1", "PSMA1", "PSMA3", "PSMA4", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC3", "PSMD10", "PSMD14", "PSME3", "PSME4", "PSPC1", "PTBP1", "PTBP2", "PTCD1", "PTCD3", "PTDSS1", "PTGES2", "PTGES3", "PTGR1", "PTK7", "PTRH2", "PUF60", "PURA", "PUS1", "PUS7", "PWP1", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QDPR", "QKI", "RAB10", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB21", "RAB23", "RAB24", "RAB2A", "RAB35", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RAB8A", "RABGAP1", "RACGAP1", "RACK1", "RAD21", "RAD23A", "RAD23B", "RAD50", "RAE1", "RAI14", "RALA", "RALY", "RAN", "RANBP2", "RANBP3", "RANGRF", "RAPGEF2", "RARS", "RARS2", "RB1", "RBBP4", "RBBP6", "RBBP7", "RBM10", "RBM14", "RBM17", "RBM22", "RBM25", "RBM28", "RBM3", "RBM39", "RBM4", "RBM5", "RBM8A", "RBMX", "RCC1", "RCC2", "RCL1", "RCOR1", "REEP4", "RELA", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RIF1", "RINT1", "RIOK2", "RIOX1", "RMC1", "RMDN3", "RNASET2", "RNF2", "RNF40", "ROCK1", "ROCK2", "RPA1", "RPA2", "RPAP1", "RPF2", "RPL10", "RPL13A", "RPP30", "RPRD1B", "RPS3", "RPS3A", "RPS6KA1", "RPS6KA3", "RPSA", "RRBP1", "RRM1", "RRM2", "RRP1", "RRP1B", "RRP8", "RRS1", "RSF1", "RSL24D1", "RTCB", "RTN3", "RTN4", "RTRAF", "RUFY1", "RUVBL1", "RUVBL2", "S100A13", "SAE1", "SAFB", "SAFB2", "SAMHD1", "SAP130", "SAP18", "SAP30BP", "SAR1A", "SARNP", "SARS", "SARS2", "SART1", "SART3", "SASS6", "SBDS", "SC5D", "SCAMP2", "SCAMP3", "SCARB1", "SCARB2", "SCD", "SCFD1", "SCML2", "SCP2", "SCRIB", "SCRN1", "SDE2", "SDF4", "SDHA", "SDHB", "SEC16A", "SEC22B", "SEC23A", "SEC24A", "SEC24B", "SEC24C", "SEC24D", "SEC31A", "SEC61A1", "SEC61B", "SEC61G", "SEC62", "SEC63", "SEH1L", "SEL1L", "SENP3", "SEPT2", "SEPT7", "SEPT9", "SERPINH1", "SET", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFSWAP", "SFXN1", "SFXN2", "SFXN4", "SGPL1", "SGTA", "SH3GL1", "SH3GLB1", "SH3PXD2B", "SHMT1", "SHMT2", "SIGMAR1", "SIL1", "SIN3A", "SKIV2L2", "SKP1", "SKP2", "SLC12A2", "SLC12A9", "SLC16A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A17", "SLC25A19", "SLC25A20", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A4", "SLC25A42", "SLC25A44", "SLC25A5", "SLC25A6", "SLC27A2", "SLC27A4", "SLC29A1", "SLC30A5", "SLC35B2", "SLC35F1", "SLC35F2", "SLC38A2", "SLC3A2", "SLC4A7", "SLC9A3R1", "SLFN11", "SLIRP", "SLIT2", "SLK", "SMARCA1", "SMARCA4", "SMARCAD1", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC6", "SMCHD1", "SMN1*", "SMNDC1", "SMU1", "SND1", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNW1", "SNX1", "SNX2", "SNX27", "SNX3", "SNX5", "SNX6", "SNX9", "SON", "SORT1", "SPATA5", "SPC25", "SPEN", "SPNS1", "SPTLC1", "SPTLC2", "SQSTM1", "SRCAP", "SREK1", "SRM", "SRPK1", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF2", "SRSF3", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSBP1", "SSRP1", "STAG2", "STAM", "STAMBP", "STARD3", "STAT1", "STAT3", "STAU1", "STAU2", "STMN1", "STRAP", "STRBP", "STUB1", "STX18", "STX4", "STX5", "STX8", "STXBP3", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGP2", "SUGT1", "SUN1", "SUPT16H", "SUPT5H", "SUPT6H", "SUZ12", "SYAP1", "SYMPK", "SYNCRIP", "SYNGR2", "SYS1", "TACC3", "TACO1", "TAF6L", "TALDO1", "TAMM41", "TARDBP", "TARS", "TARS2", "TBCB", "TCEA1", "TCERG1", "TDP2", "TDRKH", "TECR", "TERF2IP", "TEX264", "TFAM", "TFCP2", "TFG", "TFRC", "THOC1", "THOC2", "THOC3", "THOC6", "THRAP3", "TIAL1", "TIGAR", "TIMM13", "TIMM17A", "TIMM17B", "TIMM23", "TIMM44", "TIMM50", "TIMM8A", "TIMM8B", "TK1", "TLN1", "TMCO1", "TMED10", "TMED2", "TMED5", "TMED7", "TMED9", "TMEM109", "TMEM14C", "TMEM214", "TMX1", "TMX4", "TNPO1", "TNPO3", "TOLLIP", "TOM1", "TOMM20", "TOMM22", "TOMM40", "TOMM5", "TOMM70", "TOP1", "TOP2A", "TP53", "TP53BP2", "TPI1", "TPR", "TPX2", "TRA2A", "TRA2B", "TRAF2", "TRAM1", "TRAPPC11", "TRAPPC3", "TRAPPC4", "TRAPPC5", "TRIM21", "TRIM25", "TRIM28", "TRIM33", "TRIP12", "TRIP13", "TRMT10C", "TRMT1L", "TRMT6", "TROVE2", "TSFM", "TSG101", "TSNAX", "TSR1", "TTC19", "TTC26", "TTC4", "TTLL12", "TTYH3", "TUBB2B", "TUFM", "TWF2", "TXLNA", "TXLNG", "TXNL1", "TXNRD1", "TYMS", "U2AF2", "UBA1", "UBA2", "UBA3", "UBA6", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2O", "UBE2Q1", "UBE2S", "UBE3C", "UBE4A", "UBR2", "UBR4", "UBR5", "UBR7", "UBTF", "UCHL5", "UFC1", "UFD1", "UFL1", "UGCG", "UGDH", "UHRF1", "UMPS", "UNC119B", "UNC45A", "UPF1", "UQCR10", "UQCRC1", "UQCRC2", "UQCRQ", "UROD", "USO1", "USP10", "USP11", "USP14", "USP24", "USP28", "USP34", "USP39", "USP47", "USP48", "USP5", "USP7", "USP8", "USP9X", "UTP14A", "UTP15", "UTP18", "UTP20", "UTP4", "UTP6", "VAMP7", "VAPA", "VAPB", "VARS1", "VCL", "VCP", "VDAC1", "VDAC2", "VDAC3", "VIM", "VMP1", "VPS16", "VPS18", "VPS26A", "VPS29", "VPS33B", "VPS35", "VPS4A", "VPS4B", "VPS51", "VPS53", "VRK1", "WAPL", "WARS", "WBP11", "WDR12", "WDR33", "WDR36", "WDR4", "WDR41", "WDR43", "WDR5", "WDR6", "WDR61", "WDR75", "WIPI2", "WLS", "WTAP", "XAB2", "XPO1", "XPO4", "XPO5", "XPO7", "XPOT", "XRCC5", "XRCC6", "XRN2", "YARS", "YARS2", "YBX1", "YKT6", "YLPM1", "YTHDC1", "YTHDC2", "YTHDF2", "YTHDF3", "YWHAB", "YWHAE", "ZC3H11A", "ZC3HAV1", "ZCCHC11", "ZCCHC3", "ZCCHC8", "ZNF280C", "ZNF318", "ZNF326", "ZNF638", "ZPR1", "ZW10", "ZYX"], "leading_proteins": ["ACOX1", "ACP6", "ACTL6A", "AIFM1", "AKT2", "APOL2", "APP", "ARL6IP1", "ARMC10", "ARV1", "ASAH1", "ATP1A1", "ATP1B1", "ATP2A2", "ATP5F1", "ATP5L", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP7B", "BAG6", "BSG", "C1QBP", "CAMK1", "CERS2", "CHKA", "CLCC1", "CLCN3", "CLCN7", "CLPTM1L", "CNNM4", "COL4A3BP", "COQ3", "CPT2", "CYB5B", "CYB5D2", "CYFIP1", "CYP51A1", "DERL1", "DHCR24", "DHCR7", "DNASE2", "DNM2", "DSC3", "DSG2", "ELMO2", "ELP3", "EPHA7", "ERAP1", "ERG28", "ERLIN1", "EXO1", "FAM162A", "FDFT1", "FIS1", "FMR1", "FOXRED1", "GBA", "GHITM", "GM2A", "GORASP2", "GPAM", "HADH", "HIBCH", "HLA-A", "HLA-B", "HLA-C", "HSD17B11", "HSD17B12", "IDH1", "IDH2", "KDSR", "KIFBP", "KMT2A", "LBR", "LDAH", "LGALS3BP", "LIPA", "LPCAT3", "LPGAT1", "LSS", "LTA4H", "MAVS", "MBOAT7", "MFN2", "MGST2", "MINDY3", "MORF4L2", "MTCH1", "NAP1L1", "NDUFB10", "NDUFB3", "NDUFS2", "NME7", "NPC1", "NPC2", "NRP1", "NSUN2", "NT5C3B", "OTUB1", "PAK2", "PDCD5", "PDCL3", "PLA2G15", "PLBD2", "PLD3", "PLD6", "PODXL", "PPT1", "PSAP", "PTGES2", "PTGR1", "PUF60", "PYCR1", "PYCR2", "QDPR", "RACGAP1", "RACK1", "RALA", "RBM14", "RNASET2", "RTN3", "RUVBL1", "RUVBL2", "SC5D", "SEPT7", "SFXN4", "SGPL1", "SIGMAR1", "SLC12A2", "SLC16A1", "SLC1A5", "SLC25A3", "SLC25A4", "SLC25A44", "SLC25A5", "SLC25A6", "SLC27A2", "SLC30A5", "SLC38A2", "SLC3A2", "SLC4A7", "SLIT2", "SMARCB1", "SMN1*", "SORT1", "SPTLC1", "SQSTM1", "TDRKH", "TIAL1", "TIMM17A", "TIMM17B", "TOMM22", "TRAM1", "TSG101", "TTC19", "TTYH3", "UGCG", "UQCR10", "UQCRQ", "VAMP7", "VDAC1", "VDAC2", "VDAC3", "VMP1", "YTHDF2", "ZCCHC3"]} \ No newline at end of file diff --git a/protein_atlas_disease_involvement/advanced/idx2term.json b/protein_atlas_disease_involvement/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..9e26dfeeb6e641a33dae4961196235bdb965b21b --- /dev/null +++ b/protein_atlas_disease_involvement/advanced/idx2term.json @@ -0,0 +1 @@ +{} \ No newline at end of file diff --git a/protein_atlas_disease_involvement/basic/idx2term.json b/protein_atlas_disease_involvement/basic/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..660ebab288a7b30ca417510c2e1e48b5e8b77e37 --- /dev/null +++ b/protein_atlas_disease_involvement/basic/idx2term.json @@ 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a/protein_atlas_disease_involvement/df_merge.tsv b/protein_atlas_disease_involvement/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..369adc14082e2f3bf3088b5e38aae276346d5cda --- /dev/null +++ b/protein_atlas_disease_involvement/df_merge.tsv @@ -0,0 +1,3 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Gangliosidosis 4 5 2.461801489580267 0.0138241156578455 2.8567961165048543 4.902912621359223 0.2158556094961241 0.1574800557957235 1.2213224676890235 0.2960767122713962 1.9039254823866087 0.2239345049259472 2.107994270231121e-07 1.0361647864625089e-06 3.9836639152197847e-08 8.018093555049281e-09 2.618746245991888e-07 +Amyotrophic lateral sclerosis 4 13 2.2847337656846047 0.0223284434649964 3.0533980582524274 13.87864077669903 0.4936496443371127 0.508408134121438 2.1804655926597256 1.4762949218233254 0.8513354672584855 0.3027847309213633 0.0782260641005113 1.0 1.0 0.0070923684446229 0.0178313437064756 diff --git a/protein_atlas_disease_involvement/metrics.json b/protein_atlas_disease_involvement/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..b4658580d5b1862682265eaa82ef423a6c8d5415 --- /dev/null +++ b/protein_atlas_disease_involvement/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2644, + "annotations_size": 110, + "title": "Average number of proteins per term", + "value": 19.21818181818182 +} \ No newline at end of file diff --git a/protein_atlas_disease_involvement/paths.json b/protein_atlas_disease_involvement/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..0a57f2c3aa50ec300811c5ceee206282b5e103ca --- /dev/null +++ b/protein_atlas_disease_involvement/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/protein_atlas_disease_involvement/fragment/C197/C197_val_log2fc"} \ No newline at end of file diff --git a/protein_atlas_disease_involvement/result.tsv b/protein_atlas_disease_involvement/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..b2740a19407b889ffd88db659db2a1f6f22c70f6 --- /dev/null +++ b/protein_atlas_disease_involvement/result.tsv @@ -0,0 +1,34 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Gangliosidosis 0.9583175445244416 2.461801489580267 0.0138241156578455 0.783737308571478 0.6834535808400362 5 P17900,P16278,P07602,P06865 4 +Mucopolysaccharidosis 0.9606060606060616 2.315014816472025 0.0206121212269652 0.8988374607668203 0.6834535808400362 4 P15586,P16278,P54802 3 +Amyotrophic lateral sclerosis 0.7067035903630368 2.2847337656846047 0.0223284434649964 0.9165881324247918 0.6834535808400362 13 Q13501,P35637,Q99720,Q9H9T3 4 +Neuronal ceroid lipofuscinosis 0.978038621734193 2.0612494129629835 0.0392792516114219 0.9878188381432248 0.6834535808400362 3 P50897,O75503 2 +Hypotrichosis 0.7378553275222108 1.722406540029466 0.0849958997989654 0.9999429133682392 0.6834535808400362 7 P48449,Q14574 2 +Niemann-Pick disease 0.9560938682816044 1.5574340646711602 0.1193674637013664 0.9999991539033424 0.6834535808400362 2 P61916 1 +Gaucher disease 0.9269492808478406 1.438095254280741 0.1504070289882857 0.9999999836619518 0.6834535808400362 2 P07602 1 +Hirschsprung disease 0.90915972747918 1.365371818563366 0.1721362166914284 0.9999999990549012 0.6834535808400362 2 P42892 1 +Ehlers-Danlos syndrome 0.79635481182375 1.335161321259012 0.1818235530476295 0.9999999997410792 0.6834535808400362 3 Q9NWM8 1 +Spinocerebellar ataxia 0.5931241251098143 1.2950561866117831 0.1953008476091144 0.9999999999583428 0.6834535808400362 9 Q8IV08 1 +Premature ovarian failure 0.7762809920411298 1.254249512062508 0.2097513286406318 0.9999999999943244 0.6834535808400362 3 Q06787 1 +Neurodegeneration 0.4096051691863487 1.1173204723955554 0.2638573251375558 0.9999999999999976 0.7311875709583348 110 Q13510,O95831,O75503,O15270,P50897,P05067,Q13501,P07196,P35637,Q14108,P06865,Q10713,O75787,O15269,O75477,Q15041,P54802,Q8IV08,O14773,P04062,Q16637,Q96A57,Q9H9T3,P50995,Q99720,P07686,O95140 27 +Rhizomelic chondrodysplasia punctata 0.788417865253594 0.8829631124015624 0.3772562021037562 1.0 0.8287834814141707 2 O15228 1 +Primary microcephaly 0.5018686211438304 0.8263693341999209 0.4085946135359373 1.0 0.8287834814141707 9 Q86XL3 1 +Congenital disorder of glycosylation 0.4418717601544563 0.7907418059467105 0.4290946750012874 1.0 0.8287834814141707 14 O75787,Q8N511,Q9BV10,Q9BT22,Q15904 5 +Parkinsonism 0.4490169195237449 0.6409632746084214 0.5215465440323217 1.0 0.9065423911038948 10 O75787,P04062,Q96A57 3 +Progressive external ophthalmoplegia 0.7138531415594209 0.6095874589646535 0.5421351212406904 1.0 0.9065423911038948 2 P12235 1 +Palmoplantar keratoderma 0.5095860569034295 0.6034413970446216 0.5462150899342384 1.0 0.9065423911038948 6 P53634 1 +Zellweger syndrome 0.7074186222558627 0.587557042171198 0.5568296521977689 1.0 0.9065423911038948 2 O75381 1 +Peroxisome biogenesis disorder 0.7074186222558627 0.587557042171198 0.5568296521977689 1.0 0.9065423911038948 2 O75381 1 +Obesity 0.5265151515151572 0.5470335707366505 0.5843556686586364 1.0 0.9069377102328408 4 Q2M1P5,Q9Y4W2,Q9C0B1 3 +Osteogenesis imperfecta 0.4631827212356129 0.5455328881015975 0.5853870675139246 1.0 0.9069377102328408 8 Q32P28 1 +FDA approved drug targets 0.3490368060901161 0.5274808722284979 0.5978596960044176 1.0 0.9133967577845268 101 P12235,Q16836,P05067,Q16850,O75874,P20618,P21964,P55011,Q16739,P16615,P49721,P20645,P62942,P28074,Q16637,Q15758,P23786,P10253,P12236,P02786,Q14534,Q13423,Q99720,Q96QD8,P48735 25 +Dystonia 0.4643993852692841 0.4213172161976757 0.6735234602838849 1.0 0.943474782255836 6 O75569,P35270 2 +Cushing syndrome 0.507679258582222 0.2991962102879448 0.7647903406886178 1.0 1.0 3 P10644 1 +Nemaline myopathy 0.60522331566994 0.2878002013823089 0.7734996832052103 1.0 1.0 2 P06753 1 +Parkinson disease 0.384714350304464 0.1743178867218506 0.8616156428764461 1.0 1.0 7 P04062 1 +Cataract 0.3275729034605429 0.1505693740503232 0.8803154218771725 1.0 1.0 24 O76024,Q9H6K4,P48449,O15228,O00116,Q8TC12,Q8N2K0,P18074 8 +Hereditary spastic paraplegia 0.3548998168647551 0.1418277762157025 0.8872160435931729 1.0 1.0 9 Q8N0X7,O75477,Q15041 3 +Bardet-Biedl syndrome 0.5261165783497267 0.139104251388091 0.8893677687689878 1.0 1.0 2 Q2M1P5 1 +Dyskeratosis congenita 0.3619840969329826 0.0674625762993648 0.946213453910724 1.0 1.0 3 O95453,O60832 2 +Williams-Beuren syndrome 0.3474343495228306 0.0618923450776211 0.9506485635554388 1.0 1.0 7 Q96P11 1 +Primary mitochondrial disease 0.2878368445918027 0.0600010121674457 0.9521548285513924 1.0 1.0 71 P12235,O95831,O43819,Q9UBX3,P20674,Q96IX5,Q9BW92,Q9BRT2,Q6DKK2,O75208,P00403,Q5XKP0,Q6P4A7,Q9NPL8,Q70HW3,O14949,Q96CU9,O75306,O43676,Q07021 20 diff --git a/protein_atlas_disease_involvement/selections.json b/protein_atlas_disease_involvement/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..aeef1d91558351873ae32fee003f376e8e601490 --- /dev/null +++ b/protein_atlas_disease_involvement/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["Aicardi-Goutieres syndrome", "Albinism", "Allergen", "Alport syndrome", "Alzheimer disease", "Amelogenesis imperfecta", "Amyloidosis", "Amyotrophic lateral sclerosis", "Atrial fibrillation", "Autism", "Autism spectrum disorder", "Bardet-Biedl syndrome", "Bartter syndrome", "Cancer-related genes", "Cardiomyopathy", "Cataract", "Charcot-Marie-Tooth disease", "Ciliopathy", "Cockayne syndrome", "Cone-rod dystrophy", "Congenital adrenal hyperplasia", "Congenital disorder of glycosylation", "Congenital hypothyroidism", "Congenital muscular dystrophy", "Congenital myasthenic syndrome", "Craniosynostosis", "Cushing syndrome", "Deafness", "Diabetes insipidus", "Diabetes mellitus", "Diamond-Blackfan anemia", "Disease variant", "Dwarfism", "Dyskeratosis congenita", "Dystonia", "Dystroglycanopathy", "Ectodermal dysplasia", "Ehlers-Danlos syndrome", "Elliptocytosis", "Emery-Dreifuss muscular dystrophy", "Epidermolysis bullosa", "Epilepsy", "FDA approved drug targets", "Fanconi anemia", "Gangliosidosis", "Gaucher disease", "Glaucoma", "Glutaricaciduria", "Glycogen storage disease", "Gout", "Hereditary hemolytic anemia", "Hereditary nonpolyposis colorectal cancer", "Hereditary spastic paraplegia", "Hermansky-Pudlak syndrome", "Hirschsprung disease", "Holoprosencephaly", "Hypogonadotropic hypogonadism", "Hypotrichosis", "Ichthyosis", "Intrahepatic cholestasis", "Joubert syndrome", "Kallmann syndrome", "Kartagener syndrome", "Leber congenital amaurosis", "Leber hereditary optic neuropathy", "Leigh syndrome", "Leukodystrophy", "Li-Fraumeni syndrome", "Limb-girdle muscular dystrophy", "Lissencephaly", "Long QT syndrome", "Mental retardation", "Metachromatic leukodystrophy", "Microphthalmia", "Mucopolysaccharidosis", "Myofibrillar myopathy", "Nemaline myopathy", "Nephronophthisis", "Neurodegeneration", "Neuronal ceroid lipofuscinosis", "Neuropathy", "Niemann-Pick disease", "Non-syndromic deafness", "Obesity", "Osteogenesis imperfecta", "Osteopetrosis", "Palmoplantar keratoderma", "Parkinson disease", "Parkinsonism", "Peroxisome biogenesis disorder", "Phenylketonuria", "Pontocerebellar hypoplasia", "Premature ovarian failure", "Primary ciliary dyskinesia", "Primary hypomagnesemia", "Primary microcephaly", "Primary mitochondrial disease", "Progressive external ophthalmoplegia", "Proto-oncogene", "Pyropoikilocytosis", "Retinitis pigmentosa", "Rhizomelic chondrodysplasia punctata", "SCID", "Schizophrenia", "Spinocerebellar ataxia", "Systemic lupus erythematosus", "Tumor suppressor", "Williams-Beuren syndrome", "Xeroderma pigmentosum", "Zellweger syndrome"], "available_proteins": ["AAAS", "AARS", "AARS2", "ABCB1", "ABCB7", "ABHD12", "ABI1", "ACAD9", "ACADM", "ACADSB", "ACADVL", "ACAT1", "ACLY", "ACO2", "ACOX1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN2", "ACTN4", "ADAR", "ADD3", "ADK", "ADNP", "ADPRHL2", "ADSL", "AFDN", "AFG3L2", "AGK", "AGL", "AGPS", "AHCY", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AKAP12", "AKAP13", "AKR1B1", "AKT2", "ALDH18A1", "ALDH2", "ALDH3A2", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDOA", "ALDOC", "ALG1", "ALG12", "ANAPC1", "ANKLE2", "ANLN", "ANO10", "ANXA1", "ANXA11", "ANXA2", "ANXA7", "AP1B1", "AP1S2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "APEX1", "APOL2", "APP", "APRT", "ARCN1", "ARHGDIA", "ARHGEF2", "ARID1A", "ARID3B", "ARIH1", "ARL2", "ARL3", "ARL6IP1", "ARSA", "ARV1", "ASAH1", "ASNS", "ASPH", "ASPSCR1", "ATAD1", "ATAD3A", "ATIC", "ATP1A1", "ATP2A2", "ATP2C1", "ATP5A1", "ATP6", "ATP6AP1", "ATP6AP2", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1E1", "ATP7B", "ATXN10", "AURKA", "B4GAT1", "BAG3", "BANF1", "BAZ1B", "BCAP31", "BCAS3", "BCLAF1", "BCS1L", "BICD2", "BIRC6", "BLMH", "BMS1", "BPTF", "BRAT1", "BUB1B", "BUD23", "C19orf70", "C1QBP", "CAD", "CALM3", "CALR", "CAMK2G", "CANX", "CAPN1", "CARM1", "CARS", "CASK", "CAST", "CBL", "CBX2", "CCAR1", "CCAR2", "CCDC22", "CCDC47", "CCDC6", "CCNB1", "CCNB2", "CCT5", "CDC20", "CDC25C", "CDC27", "CDC34", "CDC37", "CDC42", "CDC73", "CDK1", "CDK2", "CDK4", "CDK5", "CDK6", "CDX2", "CENPF", "CEP55", "CFL2", "CHAMP1", "CHD4", "CHM", "CHMP2B", "CHST14", "CISD2", "CIZ1", "CKB", "CKMT1A*", "CLCC1", "CLCN7", "CLIC1", "CLIP1", "CLN5", "CLPB", "CLPP", "CLPX", "CLTC", "CNNM4", "CNOT1", "CNOT2", "CNOT3", "COL4A3BP", "COLGALT1", "COMT", "COPA", "COPB2", "COQ8A", "COQ9", "CORO1A", "COX2", "COX4I1", "COX5A", "CPOX", "CPSF1", "CPT2", "CRK", "CRTAP", "CSDE1", "CSE1L", "CSNK2A1", "CSNK2A2", "CSNK2B", "CSTB", "CTBP1", "CTH", "CTNNB1", "CTNNBL1", "CTNND1", "CTSA", "CTSB", "CTSC", "CTTN", "CTU2", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CWF19L1", "CXorf56", "CYB5R3", "CYC1", "CYP51A1", "DARS", "DARS2", "DBN1", "DCPS", "DCTN1", "DDOST", "DDRGK1", "DDX10", "DDX3X", "DDX41", "DDX5", "DDX6", "DEK", "DHCR24", "DHCR7", "DHFR", "DHX16", "DHX30", "DHX37", "DHX9", "DIABLO", "DIAPH1", "DIAPH2", "DIAPH3", "DIS3", "DKC1", "DLD", "DLST", "DNA2", "DNAAF5", "DNAJB1", "DNAJC2", "DNAJC3", "DNM1L", "DNM2", "DNMT1", "DOCK7", "DPM1", "DSC3", "DSG2", "DSP", "DST", "DYNC1H1", "DYNC2H1", "DYNLL1", "ECE1", "ECHS1", "EDC3", "EEF1A2", "EEF2", "EFL1", "EFTUD2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2S2", "EIF3E", "EIF3F", "EIF3H", "EIF4A3", "EIF4E", "EIF4G1", "EIF4H", "EIF5A", "ELAC2", "ELP1", "ELP2", "ELP3", "EMC1", "EMD", "EMG1", "ENO1", "ENO2", "EPB41", "EPHA7", "EPHX1", "EPPK1", "EPRS", "EPS15", "ERAL1", "ERCC2", "ERLIN1", "ERLIN2", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXOSC2", "EXOSC3", "EZR", "FAF1", "FAH", "FANCI", "FAR1", "FARSB", "FASN", "FBXO7", "FDPS", "FECH", "FEN1", "FGFR1OP", "FH", "FIP1L1", "FKBP10", "FKBP14", "FKBP1A", "FKBP5", "FKBP8", "FLAD1", "FLNA", "FLNB", "FLNC", "FMR1", "FNTB", "FOXRED1", "FSCN1", "FTO", "FUBP1", "FUCA1", "FUS", "G6PD", "GAA", "GALK1", "GALM", "GALNT2", "GANAB", "GAPDH", "GARS", "GART", "GBA", "GCDH", "GCLC", "GCLM", "GDI1", "GEMIN4", "GFM1", "GFPT1", "GGCX", "GIGYF2", "GLA", "GLB1", "GLDC", "GLMN", "GLO1", "GLRX5", "GLS", "GLUD1", "GM2A", "GMPPB", "GMPS", "GNA13", "GNAI1", "GNAI3", "GNPAT", "GNS", "GOPC", "GOT1", "GOT2", "GPI", "GRB2", "GSK3B", "GSR", "GSS", "GSTM3", "GSTZ1", "GTF2I", "GTPBP3", "GUF1", "GUSB", "H4C1*", "HADH", "HADHA", "HADHB", "HCCS", "HCFC1", "HDAC2", "HELLS", "HEXA", "HEXB", "HIBCH", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLCS", "HMBS", "HMGA1", "HMGB3", "HMOX1", "HNRNPA1", "HNRNPA2B1", "HNRNPDL", "HNRNPH2", "HNRNPK", "HNRNPU", "HPRT1", "HSD17B10", "HSD17B4", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA4", "HSPA8", "HSPA9", "HSPB1", "HSPD1", "HSPE1", "HSPH1", "HTATIP2", "HUWE1", "HYOU1", "IARS", "IARS2", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IFT27", "IGBP1", "IGF2R", "ILF3", "IMPDH1", "IMPDH2", "IPO7", "IRF2BPL", "IRS4", "ITGB1", "ITPA", "IVD", "JUP", "KARS", "KDM1A", "KDM3B", "KDSR", "KIF11", "KIF22", "KIF2A", "KIF2C", "KIF4A", "KIF5B", "KIF7", "KIFBP", "KMT2A", "KTN1", "LARS", "LARS2", "LAS1L", "LASP1", "LBR", "LDHA", "LDHB", "LEMD2", "LEMD3", "LGALS3", "LGALS3BP", "LGMN", "LIPA", "LMNA", "LMNB1", "LMNB2", "LONP1", "LRBA", "LRPPRC", "LSS", "LTA4H", "M6PR", "MACF1", "MAD2L1", "MAGED2", "MAN2B1", "MAP1B", "MAP2K1", "MAP4", "MAPK1", "MARS", "MATR3", "MBOAT7", "MCCC1", "MCCC2", "MCL1", "MCM2", "MCM3", "MCM5", "MCM7", "MDC1", "MDH1", "MDH2", "MECP2", "MED1", "MED23", "MED25", "MFN2", "MICU1", "MID1", "MIF", "MINPP1", "MIPEP", "MKI67", "MOGS", "MPI", "MRE11", "MRPL12", "MRPL3", "MRPL44", "MRPS2", "MRPS22", "MRPS23", "MRPS28", "MRPS34", "MRPS7", "MSH2", "MSH6", "MSI2", "MSN", "MSTO1", "MTA1", "MTMR2", "MTOR", "MTPAP", "MTR", "MVK", "MYH10", "MYH14", "MYH9", "MYO6", "NAA15", "NAGLU", "NAMPT", "NANS", "NAXE", "NBN", "NCAPD2", "NCAPH", "NCKIPSD", "NCSTN", "NDUFA10", "NDUFA4", "NDUFA9", "NDUFAF4", "NDUFB3", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS6", "NDUFS7", "NDUFV1", "NDUFV2", "NECAP1", "NEFL", "NEK9", "NFU1", "NHLRC2", "NHP2", "NIPBL", "NME1", "NNT", "NONO", "NOP56", "NPC1", "NPC2", "NPM1", "NRP1", "NSD2", "NSDHL", "NSUN2", "NSUN5", "NT5C2", "NTHL1", "NUCB2", "NUDT1", "NUMA1", "NUP107", "NUP133", "NUP155", "NUP160", "NUP188", "NUP205", "NUP214", "NUP37", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NXN", "OAT", "OCLN", "OCRL", "OGDH", "OGT", "OPA1", "OPA3", "OSGEP", "OTULIN", "P3H1", "P4HB", "PABPC1", "PABPN1", "PAF1", "PAFAH1B1", "PAFAH1B2", "PAK1", "PARK7", "PARN", "PARP1", "PBRM1", "PC", "PCBD1", "PCBP1", "PCCA", "PCM1", "PCNA", "PDAP1", "PDCD4", "PDE6D", "PDHA1", "PDHB", "PDK1", "PDK3", "PDXK", "PEPD", "PEX14", "PEX19", "PFKM", "PFN1", "PGK1", "PGM1", "PGM3", "PHB", "PHF6", "PHF8", "PHGDH", "PHIP", "PHKA1", "PICALM", "PIGT", "PIK3C2A", "PIN1", "PISD", "PKM", "PLAA", "PLCG1", "PLD3", "PLEC", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLS3", "PMPCA", "PMPCB", "PNN", "PNP", "PNPT1", "POGZ", "POLA1", "POLD1", "POLE", "POLE3", "POLE4", "POLR1A", "POLR1B", "POLR3A", "POP1", "POR", "PPA2", "PPIB", "PPIF", "PPP1CB", "PPP2R1A", "PPP2R5D", "PPP5C", "PPP6C", "PPT1", "PQBP1", "PRCC", "PRDX2", "PRDX4", "PRDX5", "PREPL", "PRKAG1", "PRKAR1A", "PRKCD", "PRKCSH", "PRKDC", "PRKRA", "PRPF3", "PRPF31", "PRPF4", "PRPF6", "PRPF8", "PRPS1", "PSAP", "PSAT1", "PSIP1", "PSMB1", "PSMB2", "PSMB4", "PSMB5", "PSMD12", "PSMD4", "PTDSS1", "PTPN11", "PTRH2", "PUF60", "PURA", "PUS1", "PUS7", "PYCR1", "PYCR2", "PYGL", "QARS", "QDPR", "QKI", "RAB10", "RAB18", "RAB23", "RAB3GAP2", "RAB7A", "RAB8A", "RAC1", "RAD21", "RAD23A", "RAD23B", "RANBP2", "RANBP3", "RAPGEF2", "RARS", "RARS2", "RB1", "RBBP4", "RBM10", "RBM12", "RBM28", "RBMX", "RDH11", "RDX", "RELA", "REPS1", "RFC1", "RFC2", "RHEB", "RINT1", "RMC1", "RNASEH2A", "RNASET2", "ROCK1", "ROCK2", "RPA2", "RPL10", "RPL11", "RPL13", "RPL15", "RPL18", "RPL21", "RPL22", "RPL26", "RPL27", "RPL3", "RPL35", "RPL35A", "RPL5", "RPN1", "RPS10", "RPS15A", "RPS17", "RPS19", "RPS2", "RPS23", "RPS24", "RPS3", "RPS6KA1", "RPS6KA3", "RPS7", "RPSA", "RRM1", "RRM2", "SAMHD1", "SARS", "SART1", "SASS6", "SBDS", "SC5D", "SCARB2", "SCO1", "SCO2", "SCRIB", "SDHA", "SDHB", "SEC23A", "SEC24D", "SEC31A", "SEC61A1", "SEC63", "SEPT2", "SEPT9", "SERPINB6", "SERPINH1", "SET", "SF3B1", "SFPQ", "SFXN4", "SGPL1", "SH3GL1", "SH3PXD2B", "SHOC2", "SIGMAR1", "SIL1", "SIN3A", "SKIV2L", "SKP2", "SLC12A2", "SLC16A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A19", "SLC25A20", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A4", "SLC25A42", "SLC25A5", "SLC25A6", "SLC27A4", "SLC38A2", "SLC3A2", "SLC9A3R1", "SMARCA4", "SMARCAD1", "SMARCB1", "SMARCC2", "SMARCE1", "SMC1A", "SMC3", "SMCHD1", "SMN1*", "SMPD4", "SMYD3", "SND1", "SNRNP200", "SNRPE", "SNX3", "SOD2", "SON", "SPART", "SPATA5", "SPEN", "SPR", "SPTAN1", "SPTBN2", "SPTLC1", "SPTLC2", "SQLE", "SQSTM1", "SRP54", "SRP72", "SRSF2", "SRSF3", "SSB", "SSR4", "STAG2", "STAMBP", "STARD3", "STAT1", "STAT3", "STMN1", "STRAP", "STT3A", "STT3B", "STUB1", "STX5", "SUCLA2", "SUCLG1", "SUZ12", "SYNE2", "TACO1", "TAF15", "TALDO1", "TARDBP", "TARS", "TARS2", "TBC1D4", "TBCD", "TBCE", "TBL2", "TCEA1", "TCOF1", "TDP2", "TECR", "TELO2", "TFAM", "TFG", "TFRC", "THOC2", "THOC6", "TIMM17A", "TIMM50", "TIMM8A", "TIMMDC1", "TK1", "TKT", "TMCO1", "TMEM199", "TMEM230", "TMEM43", "TMTC3", "TMX2", "TNPO3", "TOE1", "TOM1", "TOP1", "TOP2A", "TOP2B", "TOR1AIP1", "TP53", "TP53BP2", "TPD52", "TPI1", "TPM1", "TPM3", "TPM4", "TPP1", "TPR", "TPX2", "TRAF2", "TRAPPC11", "TRIM25", "TRIM33", "TRIO", "TRIP12", "TRIP13", "TRMT10C", "TSFM", "TSG101", "TTC19", "TUBB", "TUBB2A", "TUBB2B", "TUBB4A", "TUBB4B", "TUBB6", "TUBGCP2", "TUFM", "TWF1", "TXLNA", "TXNRD1", "TYMS", "UBA1", "UBE2N", "UBR5", "UBTF", "UFC1", "UGCG", "UGDH", "UGP2", "UMPS", "UQCC2", "UQCRC2", "UQCRQ", "UROD", "USMG5", "USP8", "USP9X", "UTP4", "VANGL1", "VAPB", "VARS1", "VCL", "VCP", "VIM", "VKORC1L1", "VPS16", "VPS33B", "VPS35", "VPS4A", "VPS51", "VPS53", "VRK1", "WARS", "WDR1", "WDR36", "WDR4", "WDR5", "WFS1", "WIPI2", "XPNPEP3", "XPO1", "XRCC5", "XRCC6", "YARS", "YARS2", "YBX1", "YME1L1", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAZ", "ZC3H14", "ZCCHC8", "ZMPSTE24"], "leading_proteins": ["ABHD12", "AGPS", "AIFM1", "ALG1", "ALG12", "ANKLE2", "ANXA11", "APP", "ARL6IP1", "ASAH1", "ATP2A2", "ATP6AP1", "ATP6AP2", "C19orf70", "C1QBP", "CLN5", "COMT", "COQ9", "COX2", "COX5A", "CPT2", "CTSC", "CYP51A1", "DKC1", "DSC3", "ECE1", "ELP3", "ERCC2", "ERLIN1", "FKBP14", "FKBP1A", "FMR1", "FOXRED1", "FTO", "FUS", "GAA", "GBA", "GLB1", "GM2A", "GNPAT", "GNS", "HADH", "HEXA", "HEXB", "IDH1", "IDH2", "KIF7", "LAS1L", "LSS", "M6PR", "MFN2", "NAGLU", "NDUFB3", "NDUFS2", "NEFL", "NNT", "NPC2", "NSUN5", "OPA3", "P3H1", "PARN", "PEX14", "PLD3", "PMPCA", "PPT1", "PRKAR1A", "PRKRA", "PSAP", "PSMB1", "PSMB2", "PSMB5", "RDH11", "SCARB2", "SCO2", "SFXN4", "SIGMAR1", "SLC12A2", "SLC1A5", "SLC25A10", "SLC25A26", "SLC25A4", "SLC25A6", "SLC38A2", "SMN1*", "SPART", "SPR", "SPTLC1", "SPTLC2", "SQLE", "SQSTM1", "TARS2", 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sha256:aa44398342dbdce8b1a1bdf381d6f61d95553b7c66abe515285365b6fc9feed9 +size 142843 diff --git a/protein_atlas_molecular_function/consensus.joblib b/protein_atlas_molecular_function/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..af89d7606a6671b9dde04877f67aa80df172cd64 --- /dev/null +++ b/protein_atlas_molecular_function/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:8e3e7218d5ad955e156baaac9da029e6aacb6e84f72feba09cb0a8eac2d020eb +size 65190 diff --git a/protein_atlas_molecular_function/df_merge.tsv b/protein_atlas_molecular_function/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..2a977ceb0f2a74e76769e1b9ed3fc3f46fff44a7 --- /dev/null +++ b/protein_atlas_molecular_function/df_merge.tsv @@ -0,0 +1,7 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Glycosidase 12 20 3.516689160161967 0.0004369651777129 7.798543689320389 18.135922330097088 0.5112745472223946 0.1951515073440806 2.9064203812520417 1.9684331341643595 1.9501681029822375 0.2619382904734375 8.302013177936224e-09 1.7448784274139658e-06 1.4821215929702348e-07 1.3853522260397098e-11 6.658815946322058e-10 +Receptor 19 33 3.10182881872926 0.0019232914004068 13.475728155339803 38.71116504854369 1.6655960679271569 0.1791616261110447 5.431559450288914 6.105192092581698 1.9169648296245776 0.2753083483896962 0.0010245722919161 0.3389463545940903 0.0027478834433543 3.5983180164948475e-05 0.0010611454008049 +Protease 21 75 3.0526158257049887 0.0022685616351796 20.788834951456312 82.44417475728156 1.1215350835872162 0.3507517256058336 6.07090559629836 8.079357013764625 1.4678877461728397 0.3691345771929886 2.078600041552205e-07 0.0001039893732572 4.386426258594113e-09 3.007344327503247e-06 6.584121840123534e-07 +Host cell receptor for virus entry 5 13 2.472163139307841 0.0134298214809129 4.509708737864078 15.157766990291265 0.7214109752050332 0.2527966464979699 2.499010078306418 1.9009100692398744 1.5211756979359785 0.2791170769282048 0.0003323540822832 0.1835089509173778 0.0614247268920475 0.0004801273878727 0.0007880746078161 +Carboxypeptidase 4 6 2.4703615315686203 0.0134976562788002 3.1359223300970873 6.150485436893204 0.9957728306848488 0.1212034427500092 1.2071674596015187 0.4479454254223922 1.8250051834990677 0.2074401112551974 1.6086858300830916e-06 0.0022827689145391 2.0597753624715522e-07 1.972516813028553e-05 0.0005240184523993 +Metalloprotease 11 26 2.275709947954567 0.0228633755593499 8.160194174757281 26.429611650485437 1.390302281711237 0.2661274848815638 3.192614043118206 1.543038499308978 1.1108461579919544 0.309446154241223 0.0014865586476314 0.0315268496209905 0.0022887430854204 0.0026843919056765 1.6982026956110522e-05 diff --git a/protein_atlas_molecular_function/metrics.json b/protein_atlas_molecular_function/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..85c5a69d694cbfbc1c63a8682743e9342e584dec --- /dev/null +++ b/protein_atlas_molecular_function/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2644, + "annotations_size": 96, + "title": "Average number of proteins per term", + "value": 33.28125 +} \ No newline at end of file diff --git a/protein_atlas_molecular_function/paths.json b/protein_atlas_molecular_function/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..5a0f8c863296dc17f13daf38ffa7fbbf8148aac1 --- /dev/null +++ b/protein_atlas_molecular_function/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/protein_atlas_molecular_function/fragment/C197/C197_val_log2fc"} \ No newline at end of file diff --git a/protein_atlas_molecular_function/result.tsv b/protein_atlas_molecular_function/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..9008cbc6a9587cb658c4b4800dcbb2bb3dcb5542 --- /dev/null +++ b/protein_atlas_molecular_function/result.tsv @@ -0,0 +1,29 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Glycosidase 0.8796693794516106 3.516689160161967 0.0004369651777129 0.0410897780330499 0.0419486570604449 20 P10253,P16278,O00462,P08236,P06280,P07686,P54802,P04066,Q01459,Q9BTY2,O00754,P06865 12 +Receptor 0.7739662130159378 3.1018288187292593 0.0019232914004068 0.1687409142266017 0.0725939723257483 33 Q15375,Q14108,O14786,P11717,O75787,Q14739,Q8WTV0,Q9NS69,P24390,P35613,P55899,Q5KU26,Q99523,P11279,P02786,O15173,O00264,Q99720,O15118 19 +Protease 0.5526617399776134 3.0526158257049887 0.0022685616351796 0.1958981325820721 0.0725939723257483 75 P07858,Q9HB40,Q5JRX3,P55786,Q99538,P09960,P67812,P42892,Q8TCT8,O75976,Q96FW1,O75844,O14773,P10619,Q9UIQ6,Q16740,P42785,Q9H3G5,P53634,O95630,P28072 21 +Host cell receptor for virus entry 0.7421328420663394 2.472163139307841 0.0134298214809129 0.7269221738451523 0.2084773070445018 13 P11279,Q8WTV0,P02786,O15118,Q14108 5 +Carboxypeptidase 0.9493480655684788 2.4703615315686203 0.0134976562788002 0.7287188282605498 0.2084773070445018 6 O75976,P42785,P10619,Q9HB40 4 +Metalloprotease 0.6496031410441135 2.275709947954567 0.0228633755593499 0.8914304622110325 0.274360506712199 26 O75976,O95630,Q5JRX3,P55786,Q9UIQ6,P09960,Q9BYT8,O75844,P42892,O43847,Q9NZ08 11 +Serine protease inhibitor 0.9036077064376156 2.0888369910040603 0.0367223993213547 0.9724488127429262 0.2937791945708383 4 P05067 1 +Porin 0.8727622101304762 1.9643597444788607 0.0494883877285947 0.9923455676824688 0.3301180827565911 4 P45880,P21796 2 +Heparin-binding 0.8173273965446338 1.935263126112928 0.052958014806099 0.9946117669936664 0.3301180827565911 6 O94813,P05067 2 +Protease inhibitor 0.7768711695448053 1.8953116336006788 0.0580511278253079 0.9967891225920292 0.3301180827565911 7 P05067 1 +Translocase 0.5640703481656277 1.7324264833329452 0.0831976560713356 0.999760961070136 0.3472597818629662 18 O75306,P05023,P98194,Q13423,P00403,Q9HD20,P16615,P08183,P35670 9 +Dioxygenase 0.5863957012339023 1.6154364101059504 0.1062162207318333 0.9999791878479248 0.40787028761024 13 Q9NWT6,Q9BV57,Q32P28 3 +Monooxygenase 0.8416567636089285 1.5179917251557618 0.129016484716427 0.9999982583784204 0.4380174947201087 3 Q16850 1 +Threonine protease 0.8307459295721323 1.473977419845619 0.1404876708865474 0.99999951224399 0.4380174947201087 3 P28072,Q99436 2 +Serine protease 0.6528933047298623 1.4596393605233724 0.1443892156856958 0.9999996848480572 0.4380174947201087 8 O14773 1 +Transducer 0.6652701814640225 1.3934585513197184 0.1634811705994963 0.99999996388653 0.4380174947201087 7 P02786,P04899 2 +Thiol protease 0.5059586560749583 1.3440642049906255 0.1789276258568422 0.9999999939658202 0.4404372328783807 24 Q99538,Q96FW1,P07858 3 +Acyltransferase 0.494367444334634 1.2650117196598092 0.2058671267267886 0.9999999997546734 0.4497552863831625 28 Q86UY6,P23786,Q92604,O15270,Q96N66,Q8NCC3,O15269,Q9UKN8,Q6P1A2,Q9BWD1,Q9HCL2,Q9H9T3 12 +Glycosyltransferase 0.4764008145856534 1.1405988895426749 0.2540368795802581 0.9999999999993964 0.5188838391426549 26 Q10472,P04062,P43490,Q13126,Q16739,Q9BV10,Q9BT22,O43505 8 +Endonuclease 0.4501499449520001 0.983485136554383 0.3253687270680205 1.0 0.558709163041941 20 O00584,O00115,Q9UQ84 3 +Aminopeptidase 0.4716494642192618 0.7621822543889063 0.4459512357813313 1.0 0.6389749050001166 10 P55786,Q9NZ08,Q9UIQ6 3 +Signal transduction inhibitor 0.696820590461767 0.5519458843892712 0.5809854301757091 1.0 0.7416489631306284 2 Q9NWT1 1 +Nuclease 0.393295113013083 0.5429869864960241 0.5871387624784141 1.0 0.7416489631306284 34 O00584,Q8IV08,O00115,Q9UQ84 4 +Rotamase 0.3712190094377888 0.4481443284701681 0.6540490378692216 1.0 0.7876285112563582 17 Q9Y680 1 +Guanine-nucleotide releasing factor 0.3879294560665894 0.4428893311127794 0.6578457847032042 1.0 0.7876285112563582 13 Q02818,P80303 2 +Methyltransferase 0.3761588484614392 0.4223548610622233 0.6727660200314727 1.0 0.7876285112563582 32 O96028,Q9NZJ6,Q08J23,O43159,P21964,O60725,Q96P11,Q9BV86,Q9H7B4,Q03164 10 +Oxidoreductase 0.3789214815407912 0.3636188148010632 0.7161426750335194 1.0 0.8283096000387693 145 Q9NWT6,P48163,Q16836,Q6ZRP7,P11177,Q8NBQ5,O95881,Q16850,Q96LJ7,O75874,Q6UW02,Q5VT66,P49189,O75845,Q14739,Q99735,Q9BV57,Q8N4Q0,Q9UBM7,P30519,Q9UHG3,P35270,Q15392,Q32P28,P51648,Q8NBX0,Q53GQ0,O14880,P13674,Q96CU9,O75306,Q14534,P00367,Q15067,Q06136,Q8NB78,P16435,P48735 38 +Calcium channel 0.470476911430728 0.0808033681956774 0.935598329398593 1.0 0.9632239471534434 2 Q9UM00 1 diff --git a/protein_atlas_molecular_function/selections.json b/protein_atlas_molecular_function/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..54f766e4578cdcf32e893e1d9e983086afeb12a4 --- /dev/null +++ b/protein_atlas_molecular_function/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["Actin capping", "Actin-binding", "Activator", "Acyltransferase", "Allosteric enzyme", "Aminoacyl-tRNA synthetase", "Aminopeptidase", "Aminotransferase", "Antibiotic", "Antimicrobial", "Antioxidant", "Aspartyl protease", "Blood group antigen", "Calcium channel", "Calmodulin-binding", "Carboxypeptidase", "Chaperone", "Chloride channel", "Chromatin regulator", "Cyclin", "Cytokine", "DNA-binding", "DNA-directed DNA polymerase", "Decarboxylase", "Developmental protein", "Dioxygenase", "Dipeptidase", "Elongation factor", "Endonuclease", "Excision nuclease", "Exonuclease", "Fungicide", "GTPase activation", "Glycosidase", "Glycosyltransferase", "Growth factor", "Guanine-nucleotide releasing factor", "Helicase", "Heparin-binding", "Hormone", "Host cell receptor for virus entry", "Hydrolase", "IgE-binding protein", "IgG-binding protein", "Initiation factor", "Integrin", "Ion channel", "Isomerase", "Kinase", "Ligase", "Lyase", "Metalloenzyme inhibitor", "Metalloprotease", "Methyltransferase", "Mitogen", "Monooxygenase", "Motor protein", "Multifunctional enzyme", "Muscle protein", "Myosin", "Nuclease", "Nucleotidyltransferase", "Oxidoreductase", "Peroxidase", "Phospholipase A2 inhibitor", "Porin", "Prenyltransferase", "Protease", "Protease inhibitor", "Protein phosphatase", "Protein phosphatase inhibitor", "Protein synthesis inhibitor", "RNA-binding", "Receptor", "Repressor", "Ribonucleoprotein", "Ribosomal protein", "Rotamase", "Serine esterase", "Serine protease", "Serine protease inhibitor", "Serine/threonine-protein kinase", "Signal transduction inhibitor", "Thiol protease", "Thiol protease inhibitor", "Threonine protease", "Topoisomerase", "Transducer", "Transferase", "Translational shunt", "Translocase", "Tumor antigen", "Tyrosine-protein kinase", "Voltage-gated channel", "rRNA-binding", "tRNA-binding"], "available_proteins": ["AAMP", "AARS", "AARS2", "AASDHPPT", "ABCB1", "ABCE1", "ABCF1", "ABHD10", "ABHD12", "ABHD14B", "ABHD6", "ACAA2", "ACACA", "ACACB", "ACAD9", "ACADM", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACIN1", "ACLY", "ACO2", "ACOT13", "ACOT7", "ACOT9", "ACOX1", "ACOX3", "ACP1", "ACP2", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN2", "ACTN4", "ACTR2", "ACTR3", "ADAR", "ADD1", "ADD3", "ADH5", "ADI1", "ADK", "ADNP", "ADPGK", "ADPRHL2", "ADSL", "ADSS", "AFG3L2", "AGK", "AGL", "AGPAT1", "AGPS", "AHCY", "AHCYL1", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AK1", "AK2", "AK3", "AKAP1", "AKAP12", "AKAP13", "AKAP17A", "AKAP8", "AKR1A1", "AKR1B1", "AKR7A2", "AKT2", "ALDH18A1", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALG1", "ALG12", "ALKBH5", "ANKRD17", "ANLN", "ANP32A", "ANP32B", "ANXA1", "ANXA2", "APEH", "APEX1", "APEX2", "APLP2", "APP", "APRT", "AQR", "ARFGAP1", "ARFGAP2", "ARHGAP17", "ARHGDIA", "ARHGEF2", "ARID1A", "ARID3B", "ARIH1", "ARIH2", "ARMT1", "ARPC1A", "ARPC2", "ARPC3", "ARPC4", "ARSA", "ASAH1", "ASCC3", "ASH2L", "ASNA1", "ASNS", "ASPH", "ASRGL1", "ATAD1", "ATG3", "ATIC", "ATL2", "ATP13A1", "ATP1A1", "ATP2A2", "ATP2C1", "ATP5B", "ATP6AP2", "ATP6V1A", "ATP6V1B2", "ATP6V1E1", "ATP7B", "AURKA", "B4GAT1", "BAG3", "BAG5", "BAG6", "BANF1", "BAZ1B", "BCLAF1", "BCS1L", "BIRC6", "BLMH", "BLVRA", "BPNT1", "BPTF", "BRAP", "BRD1", "BRD2", "BSG", "BTAF1", "BTF3", "BUB1B", "BUD23", "BZW1", "BZW2", "CAD", "CALCOCO1", "CALD1", "CALR", "CAMK1", "CAMK2G", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPRIN1", "CAPZA1", "CAPZA2", "CAPZB", "CARM1", "CARS", "CASK", "CAST", "CBL", "CBR1", "CBX2", "CBX3", "CCAR1", "CCAR2", "CCDC47", "CCNB1", "CCNB2", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CDC25C", "CDC34", "CDC37", "CDC42", "CDC5L", "CDK1", "CDK2", "CDK4", "CDK5", "CDK6", "CDKN2AIP", "CDX2", "CEBPZ", "CENPF", "CEP55", "CEPT1", "CERS2", "CFL1", "CFL2", "CHAC2", "CHAF1A", "CHCHD3", "CHD4", "CHKA", "CHM", "CHORDC1", "CHRAC1", "CHST14", "CHUK", "CIRBP", "CKB", "CKMT1A*", "CLCC1", "CLGN", "CLIC1", "CLIC4", "CLPB", "CLPP", "CLPTM1", "CLPX", "CLUH", "CMAS", "CMPK1", "CMTR1", "CNDP2", "CNN2", "CNN3", "CNOT1", "CNOT2", "CNOT3", "CNOT4", "CNOT7", "CNOT9", "CNP", "COLEC12", "COLGALT1", "COMT", "COPA", "COPS5", "COQ3", "COQ8A", "CORO1A", "CORO1C", "CORO7", "COTL1", "COX2", "COX4I1", "CPD", "CPNE1", "CPOX", "CPSF1", "CPSF3", "CPSF6", "CPSF7", "CPT2", "CPVL", "CRYZ", "CS", "CSDE1", "CSGALNACT2", "CSK", "CSNK1A1", "CSNK2A1", "CSNK2A2", "CSTB", "CSTF2", "CTBP1", "CTBP2", "CTBS", "CTH", "CTNNB1", "CTPS1", "CTPS2", "CTSA", "CTSB", "CTSC", "CUL5", "CXADR", "CXorf57", "CYB5R1", "CYB5R3", "CYC1", "CYFIP1", "CYP20A1", "CYP51A1", "DAP3", "DARS", "DARS2", "DAZAP1", "DBN1", "DBNL", "DCAF1", "DCAF7", "DCD", "DCPS", "DCTPP1", "DCXR", "DDB1", "DDI2", "DDT", "DDX1", "DDX10", "DDX17", "DDX18", "DDX20", "DDX21", "DDX23", "DDX24", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX50", "DDX51", "DDX52", "DDX54", "DDX56", "DDX6", "DEK", "DENR", "DHCR24", "DHCR7", "DHFR", "DHRS1", "DHRS7", "DHX15", "DHX16", "DHX29", "DHX30", "DHX36", "DHX37", "DHX8", "DHX9", "DIAPH1", "DIAPH2", "DIEXF", "DIMT1", "DIS3", "DKC1", "DLAT", "DLD", "DLST", "DNA2", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC2", "DNAJC3", "DNAJC7", "DNAJC8", "DNAJC9", "DNASE2", "DNM1L", "DNM2", "DNMT1", "DNPH1", "DOCK7", "DOHH", "DPH2", "DPH5", "DPM1", "DPP3", "DPP9", "DPY30", "DPYSL2", "DR1", "DRG1", "DRG2", "DST", "DSTN", "DTYMK", "DUSP12", "DUSP3", "DUSP9", "DUT", "DYNC1H1", "DYNC1LI1", "DYNC1LI2", "DYNC2H1", "DYNLL1", "ECD", "ECE1", "ECH1", "ECHS1", "ECI1", "ECI2", "EDC3", "EDF1", "EDRF1", "EEF1A2", "EEF1B2", "EEF1D", "EEF1G", "EEF2", "EFL1", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2D", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A3", "EIF4B", "EIF4E", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "ELAC2", "ELAVL1", "ELMOD2", "ELP3", "EMD", "EMG1", "ENAH", "ENDOD1", "ENO1", "ENO2", "ENSA", "EPB41", "EPB41L2", "EPHA7", "EPHX1", "EPHX2", "EPRS", "ERAL1", "ERAP1", "ERCC2", "ERI1", "ERMP1", "ERO1A", "ESD", "ETFDH", "EWSR1", "EXO1", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "FAH", "FAHD1", "FAM208A", "FAM213A", "FANCI", "FAR1", "FARSA", "FARSB", "FASN", "FBL", "FCGRT", "FDFT1", "FDPS", "FECH", "FEN1", "FH", "FHOD1", "FIP1L1", "FKBP10", "FKBP14", "FKBP1A", "FKBP3", "FKBP4", "FKBP5", "FKBP7", "FKBP8", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FMR1", "FN3KRP", "FNTB", "FOXRED1", "FRG1", "FSCN1", "FTO", "FTSJ3", "FUBP1", "FUBP3", "FUCA1", "FUCA2", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GADD45GIP1", "GAK", "GALK1", "GALM", "GALNT1", "GALNT2", "GALNT7", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GBA", "GBF1", "GCAT", "GCDH", "GCLC", "GCN1", "GDI1", "GDI2", "GDPD1", "GEMIN5", "GFM1", "GFPT1", "GGCT", "GGCX", "GGH", "GGNBP2", "GLA", "GLB1", "GLDC", "GLO1", "GLS", "GLUD1", "GLYR1", "GM2A", "GMFB", "GMPPB", "GMPS", "GNA13", "GNAI1", "GNAI2", "GNAI3", "GNPAT", "GNPDA1", "GNS", "GOT1", "GOT2", "GPAM", "GPD2", "GPI", "GPKOW", "GRHPR", "GRPEL1", "GRSF1", "GSK3B", "GSR", "GSS", "GSTK1", "GSTM3", "GSTO1", "GSTZ1", "GTF2I", "GTF3C1", "GTF3C3", "GTF3C4", "GUF1", "GUSB", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACD3", "HACL1", "HADH", "HADHA", "HADHB", "HAT1", "HBS1L", "HCCS", "HCFC1", "HDAC2", "HDGF", "HDLBP", "HEATR1", "HECTD1", "HECTD3", "HELLS", "HEXA", "HEXB", "HIBADH", "HIBCH", "HIF1AN", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLCS", "HLTF", "HM13", "HMBS", "HMCES", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMGCS1", "HMGN2", "HMOX1", "HMOX2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPLL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HP1BP3", "HPRT1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA14", "HSPA1B", "HSPA4L", "HSPA8", "HSPA9", "HSPB1", "HSPD1", "HSPE1", "HTATIP2", "HUWE1", "HYOU1", "IARS", "IARS2", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDI1", "IGBP1", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "ILF2", "ILF3", "ILKAP", "ILVBL", "IMP4", "IMPACT", "IMPDH1", "IMPDH2", "INA", "INTS11", "IQGAP1", "IRF2BPL", "IRS4", "ISYNA1", "ITGB1", "ITPA", "IVD", "KARS", "KDELC2", "KDELR1", "KDM1A", "KDM1B", "KDM3B", "KDSR", "KHDRBS1", "KHSRP", "KIAA0391", "KIAA1147", "KIF11", "KIF15", "KIF18B", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF4A", "KIF5B", "KIF7", "KIFBP", "KIFC1", "KLC1", "KMT2A", "KRR1", "LAMP1", "LAP3", "LARP1", "LARP4", "LARP4B", "LARS", "LARS2", "LASP1", "LBR", "LCLAT1", "LDAH", "LDHA", "LDHB", "LEMD3", "LGALS3", "LGMN", "LIG1", "LIG3", "LIMA1", "LIPA", "LNPEP", "LONP1", "LPCAT1", "LPCAT3", "LPGAT1", "LRPPRC", "LRWD1", "LSM14B", "LSM2", "LSM6", "LSM7", "LSS", "LTA4H", "LTN1", "LUC7L3", "LYAR", "LYPLA1", "M6PR", "MACF1", "MAGED2", "MAN2A1", "MAN2B1", "MANBA", "MANF", "MAP1S", "MAP2K1", "MAPK1", "MARC1", "MARCKS", "MARS", "MAT2A", "MATR3", "MBD3", "MBOAT7", "MCAT", "MCCC1", "MCCC2", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCU", "MDH1", "MDH2", "MDN1", "ME1", "MECP2", "MED1", "MED21", "MED23", "MED24", "MED25", "MED4", "MFN2", "MGEA5", "MGST2", "MGST3", "MID1", "MIF", "MINDY3", "MINPP1", "MIPEP", "MKI67", "MKRN2", "MMS19", "MOGS", "MORF4L1", "MORF4L2", "MOV10", "MPHOSPH10", "MPHOSPH6", "MPI", "MPRIP", "MPST", "MRE11", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL14", "MRPL15", "MRPL19", "MRPL21", "MRPL28", "MRPL3", "MRPL37", "MRPL38", "MRPL39", "MRPL40", "MRPL44", "MRPL46", "MRPL47", "MRPL48", "MRPL49", "MRPL50", "MRPL53", "MRPL9", "MRPS11", "MRPS2", "MRPS22", "MRPS23", "MRPS25", "MRPS27", "MRPS28", "MRPS30", "MRPS31", "MRPS33", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRPS9", "MSH2", "MSH3", "MSH6", "MSI2", "MTA1", "MTA2", "MTAP", "MTHFD1L", "MTHFD2", "MTMR2", "MTMR6", "MTOR", "MTPAP", "MTR", "MVK", "MYBBP1A", "MYG1", "MYH10", "MYH14", "MYH9", "MYL6", "MYO1B", "MYO1C", "MYO1D", "MYO6", "NAA15", "NAA40", "NAA50", "NAF1", "NAGLU", "NAMPT", "NANS", "NAP1L4", "NARS", "NAT10", "NAXE", "NCL", "NCOA5", "NDUFAF4", "NDUFAF7", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS7", "NDUFV1", "NDUFV2", "NEK9", "NELFA", "NELFCD", "NELFE", "NES", "NHP2", "NIFK", "NIPBL", "NKRF", "NLN", "NME1", "NME6", "NME7", "NMT1", "NNT", "NOB1", "NOC2L", "NOL11", "NOL6", "NOL9", "NONO", "NOP2", "NOP56", "NOP58", "NOSIP", "NPC1", "NPEPPS", "NPLOC4", "NPM1", "NRDC", "NRP1", "NSA2", "NSD2", "NSDHL", "NSF", "NSUN2", "NSUN5", "NT5C2", "NT5C3B", "NT5DC1", "NT5DC2", "NTHL1", "NTMT1", "NTPCR", "NUCB1", "NUCB2", "NUDT1", "NUDT12", "NUDT21", "NUDT5", "NUFIP2", "NUP153", "NUP98", "NXF1", "NXN", "OAT", "OCRL", "OGDH", "OGT", "OLA1", "OPA1", "OSGEP", "OTUB1", "OTULIN", "OXSR1", "P3H1", "P4HA1", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PAFAH1B1", "PAFAH1B2", "PAFAH1B3", "PAICS", "PAK1", "PAK1IP1", "PAK2", "PANK4", "PAPOLA", "PAPSS1", "PARK7", "PARN", "PARP1", "PATL1", "PBK", "PBRM1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCK2", "PCMT1", "PCNA", "PCYOX1", "PDCD4", "PDCL3", "PDE12", "PDHA1", "PDHB", "PDIA3", "PDIA4", "PDIA6", "PDK1", "PDK3", "PDLIM7", "PDRG1", "PDXDC1", "PDXK", "PEBP1", "PECR", "PELO", "PELP1", "PEPD", "PFAS", "PFDN2", "PFDN4", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGGT1B", "PGK1", "PGLS", "PGM1", "PGM2", "PGM3", "PGP", "PGRMC1", "PGRMC2", "PHB2", "PHF5A", "PHF6", "PHF8", "PHGDH", "PHKA1", "PIK3C2A", "PIK3R4", "PIN1", "PIN4", "PIP4K2C", "PIR", "PISD", "PITHD1", "PITRM1", "PKM", "PKMYT1", "PKN2", "PLA2G15", "PLAA", "PLBD2", "PLCG1", "PLD3", "PLD6", "PLEC", "PLK1", "PLOD1", "PLOD2", "PLS3", "PMPCB", "PNN", "PNO1", "PNP", "PNPT1", "POGZ", "POLA1", "POLD1", "POLDIP3", "POLE", "POLE3", "POLE4", "POLR1A", "POLR1B", "POLR2B", "POLR2G", "POLR3A", "POLR3C", "POLRMT", "PON2", "POP1", "POR", "PPA1", "PPA2", "PPAT", "PPHLN1", "PPIB", "PPID", "PPIF", "PPIG", "PPIH", "PPIL4", "PPM1G", "PPME1", "PPP1CA", "PPP1CB", "PPP1R10", "PPP4C", "PPP5C", "PPP6C", "PPT1", "PPT2", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PREP", "PREPL", "PRIM1", "PRIM2", "PRKCD", "PRKDC", "PRKRA", "PRMT1", "PRMT3", "PRMT5", "PRMT9", "PRPF19", "PRPF31", "PRPF4B", "PRPF8", "PRPS1", "PSAT1", "PSIP1", "PSMB5", "PSMB6", "PSMB7", "PSMD10", "PSMD14", "PSME4", "PSMG1", "PSMG2", "PSPC1", "PTBP1", "PTBP2", "PTCD3", "PTDSS1", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK7", "PTPA", "PTPN1", "PTPN11", "PTRH2", "PTRHD1", "PUF60", "PUM3", "PURA", "PUS1", "PUS7", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QDPR", "QKI", "QSOX2", "RAB10", "RAB18", "RAB1A", "RAB23", "RAB3GAP2", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RABGAP1", "RABGGTA", "RAC1", "RACGAP1", "RACK1", "RAD21", "RAD50", "RALA", "RALY", "RANBP1", "RANBP2", "RANGAP1", "RANGRF", "RAP2B", "RAPGEF2", "RARS", "RARS2", "RAVER1", "RB1", "RBBP4", "RBBP6", "RBBP7", "RBM10", "RBM12", "RBM12B", "RBM14", "RBM17", "RBM19", "RBM22", "RBM25", "RBM26", "RBM27", "RBM28", "RBM3", "RBM34", "RBM39", "RBM4", "RBM5", "RBM8A", "RBMX", "RCC1", "RCC2", "RCOR1", "RDH11", "RDH13", "RDX", "RECQL", "RELA", "RETSAT", "REXO4", "RFC1", "RFC3", "RHOT1", "RHOT2", "RIDA", "RIOK2", "RIOX1", "RNASEH2A", "RNASET2", "RNF2", "RNF40", "RNPEP", "ROCK1", "ROCK2", "RPA1", "RPA2", "RPAP1", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPP30", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RRM1", "RRM2", "RRP1B", "RRP8", "RSF1", "RTCB", "RTRAF", "RUVBL1", "RUVBL2", "SACM1L", "SAE1", "SAFB", "SAFB2", "SAMHD1", "SAP130", "SAP18", "SAP30BP", "SARNP", "SARS", "SARS2", "SART3", "SC5D", "SCARB1", "SCARB2", "SCCPDH", "SCD", "SCML2", "SCO1", "SCO2", "SCP2", "SCPEP1", "SCRIB", "SDE2", "SDHA", "SDHB", "SDR39U1", "SEC11A", "SEC61A1", "SEC63", "SENP3", "SEPHS1", "SERBP1", "SERPINB6", "SERPINH1", "SET", "SF1", "SF3B1", "SF3B4", "SF3B6", "SFPQ", "SFSWAP", "SGPL1", "SGTA", "SHMT1", "SHMT2", "SIGMAR1", "SIN3A", "SKIV2L", "SKIV2L2", "SLC1A5", "SLC27A2", "SLC27A4", "SLFN11", "SLIRP", "SLIT2", "SLK", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCE1", "SMCHD1", "SMN1*", "SMPD4", "SMYD3", "SND1", "SNRNP200", "SNRNP70", "SNRPA", "SNRPA1", "SNRPC", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SOD2", "SON", "SORT1", "SPATA5", "SPCS2", "SPEN", "SPPL2A", "SPR", "SPTAN1", "SPTBN1", "SPTBN2", "SPTLC1", "SPTLC2", "SQLE", "SRCAP", "SRM", "SRP14", "SRP54", "SRP68", "SRP72", "SRP9", "SRPK1", "SRPRA", "SRPRB", 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"TRMT1L", "TROVE2", "TRUB1", "TSFM", "TSN", "TSNAX", "TTK", "TTYH3", "TUFM", "TWF1", "TWF2", "TXNDC12", "TXNRD1", "TYMS", "U2AF2", "U2SURP", "UAP1", "UBA1", "UBA2", "UBA3", "UBA6", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2O", "UBE2Q1", "UBE2S", "UBE3C", "UBE4A", "UBR2", "UBR4", "UBR5", "UBR7", "UBTF", "UCHL5", "UCK2", "UFL1", "UGCG", "UGDH", "UGGT1", "UGP2", "UHRF1", "UMPS", "UNC45A", "UPF1", "UROD", "USP10", "USP11", "USP14", "USP24", "USP28", "USP34", "USP47", "USP48", "USP5", "USP7", "USP8", "USP9X", "UTRN", "VARS1", "VAT1", "VBP1", "VCL", "VCP", "VDAC1", "VDAC2", "VDAC3", "VKORC1L1", "VPS4A", "VPS4B", "VRK1", "WARS", "WDHD1", "WDR1", "WDR18", "WDR43", "WDR5", "WLS", "WTAP", "XPNPEP1", "XPNPEP3", "XPO1", "XPO5", "XPOT", "XRCC5", "XRCC6", "XRN2", "YARS", "YARS2", "YBX1", "YKT6", "YLPM1", "YME1L1", "YTHDC1", "YTHDC2", "YTHDF2", "YTHDF3", "ZADH2", "ZC3H14", "ZC3HAV1", "ZCCHC11", "ZCCHC3", "ZFR", "ZMPSTE24", "ZNF280C", "ZNF318", "ZNF326", "ZNF638"], "leading_proteins": ["ABCB1", 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sha256:da2450dfad0b29547911aad4379e99ad191ba36b4d749739ce956cc4fe99935c +size 66783 diff --git a/protein_atlas_protein_class/df_merge.tsv b/protein_atlas_protein_class/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..4b50a29b646c0ab1863a98c5ca3af8aa3a442dd9 --- /dev/null +++ b/protein_atlas_protein_class/df_merge.tsv @@ -0,0 +1,4 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +CD markers 6 9 2.68282271113366 0.0073003679807186 6.548543689320389 16.62378640776699 0.159361413045758 0.3347758559744795 3.625700175504636 4.1209525283344535 1.5119526885132668 0.3016304730463651 0.2031396520010837 0.4043878907472013 0.6461396159450896 0.2606698116599699 0.2613780119113125 +Predicted secreted proteins 25 44 2.6807268532389465 0.0073462452620425 15.29368932038835 51.737864077669904 1.393291060716792 0.256881456821794 5.463351773637434 6.9884942404294375 1.5049506819867255 0.3173597508227758 0.0001432048079239 4.583010398422979e-07 0.0002507561403829 0.0008404250100737 0.0006014943367965 +Predicted membrane proteins 205 465 2.0801652782370867 0.037510375799759 204.61650485436897 563.8058252427185 3.080866334016093 0.3028099075873978 81.17076282318972 73.52280648113661 4.068861305085399 0.4187410497068249 1.0897532502765076e-16 2.3817952899712616e-05 1.1304892940470225e-13 5.659916777854454e-27 1.936662990682745e-33 diff --git a/protein_atlas_protein_class/metrics.json b/protein_atlas_protein_class/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..710959de0bf5637ea0f7577ca2a8ed50b8c43dad --- /dev/null +++ b/protein_atlas_protein_class/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2644, + "annotations_size": 20, + "title": "Average number of proteins per term", + "value": 432.6 +} \ No newline at end of file diff --git a/protein_atlas_protein_class/paths.json b/protein_atlas_protein_class/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..d9c7208054ee5b2df8489c97d69ebc7bba407d8b --- /dev/null +++ b/protein_atlas_protein_class/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/protein_atlas_protein_class/fragment/C197/C197_val_log2fc"} \ No newline at end of file diff --git a/protein_atlas_protein_class/result.tsv b/protein_atlas_protein_class/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..d8cb1dd281f17a126377d332609d335fb8f2d007 --- /dev/null +++ b/protein_atlas_protein_class/result.tsv @@ -0,0 +1,11 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +CD markers 0.8834257445227147 2.68282271113366 0.0073003679807186 0.1363113392436353 0.0489749684136168 9 P11717,P11279,P02786,P35613,P08195,P08183 6 +Predicted secreted proteins 0.6717605379400441 2.6807268532389465 0.0073462452620425 0.137109290504101 0.0489749684136168 44 Q9UM22,O94813,P07858,Q9HB40,O00584,P80303,P05067,Q9BTY2,Q08380,Q9NZ08,O14786,P14174,P43490,O94919,P61916,Q9UMX5,Q8WUJ1,Q13308,Q9Y4P3,O75718,P02786,P78310,Q07021,Q9BUR5,Q02818 25 +Predicted membrane proteins 0.6335517949134947 2.0801652782370867 0.037510375799759 0.5344984528313701 0.1875518789987951 465 Q99595,O43657,Q9BQE5,P05067,Q16850,Q8IZA0,O60637,Q9C0H2,P42892,Q8TCT8,Q14108,Q9H6V9,O75976,P11717,Q9NQX7,Q5VW38,Q8NC54,O60830,Q9H061,P27105,P51790,O43169,P11117,Q8N2H4,Q16739,O75844,Q567V2,Q93050,Q8IV08,Q9UBM7,Q9NPR9,O00461,O75964,Q9NX00,Q5BJF2,Q06481,Q8WTV0,Q9NS69,P24390,Q8NCC3,Q92896,Q9UIQ6,O60725,Q15392,Q16625,Q15629,P53634,P10321,Q96H78,P55899,Q5KU26,Q14574,Q99523,O95772,P11279,Q9Y487,P02786,Q8N511,O43676,Q5T1Q4,O15173,Q06136,Q99720,Q86XL3,Q9NR77,O15118,Q92542,Q15904,Q9HD45,Q8TB61,Q15375,O94813,Q6ZRP7,Q9Y282,Q8IXU6,Q9UDW1,O15260,P67812,Q96G23,Q9Y619,Q9UBU6,P43307,Q13505,Q14126,P01889,Q8N2A8,O14975,O75787,O75845,Q8IY95,P04439,Q14739,Q3SXM5,Q8IYS2,O00592,Q9Y3D6,O15127,Q92804,Q96GC9,Q9BUN8,P05026,P30519,Q96N66,O60831,P50402,Q6ZT21,P35613,O43760,Q9BTX1,Q9H2C2,Q96A57,O43772,Q70HW3,Q8TAD4,O95197,Q8TAA9,O96005,O75306,Q8NCH0,Q9NX40,Q9HD20,O00264,P51809,Q96SK2,Q9Y6M7,Q9BUR5,Q96QD8,Q9H4I3,Q9P2W9,Q96CP7,Q9H3K2,P17152,O15400,P53985,Q14012,Q6UW02,Q9UBX3,Q9Y262,P08195,P08183,Q9HCL2,Q92544,O14786,Q9H6H4,O15269,Q15041,Q99735,Q99808,Q9UKR5,Q6P1A2,P20645,P35670,O95470,Q9UNK0,Q10472,P24539,Q6P4Q7,Q9NPL8,Q96KA5,Q9H1E5,P51648,Q96A33,Q5T9L3,Q00765,Q8NBX0,Q53GQ0,O14880,Q9H6K4,Q14534,Q13423,Q9Y3E0,P78310,Q9BV10,P16435,O95563,O95140,Q9NZJ7,P12235,O95831,O15270,Q8N8L6,Q96ES6,Q7Z434,Q9H2V7,O14925,Q8N2K0,Q96IX5,Q9Y5M8,O94919,P51798,P55011,Q9NPA0,Q96PC5,Q00325,P36551,P16615,O14828,Q96A26,Q9Y320,Q9BT22,Q07065,P62942,Q13308,Q6P4A7,P09601 205 +Candidate cardiovascular disease genes 0.5997836424422243 1.4560772542094274 0.14537126461201 0.95679342686127 0.4845708820400333 10 P07858 1 +Transporters 0.5239050777623178 0.7703896218229825 0.4410688077783773 0.9999911454409512 0.797399117938112 320 P07602,P05067,O60637,Q9C0H2,Q8TCT8,Q14108,P11717,Q5VW38,P45880,P61916,Q9H061,P27105,Q16739,O75844,Q93050,Q5BJF2,Q9H2D1,Q8WTV0,P24390,Q16625,Q15629,Q96H78,Q99523,P11279,P02786,Q8N511,Q5T1Q4,Q99720,Q9NR77,O15118,Q9NQZ5,Q15904,Q8TB61,Q8IXU6,O15260,Q9Y619,Q9UBU6,O14975,O75787,Q8IY95,P04439,O15127,Q96GC9,Q9BUN8,P05026,Q96N66,O60831,O00560,P35613,Q9BTX1,Q9H2C2,Q96A57,O43772,Q70HW3,Q8TAD4,Q8TAA9,O75955,O96005,Q9HD20,Q07021,Q9Y6M7,Q9BUR5,Q96QD8,P53985,Q9UBX3,P08195,P08183,Q92544,O14786,O00429,O75477,Q99808,P20645,P35670,O43681,Q6P4Q7,Q96A33,Q5T9L3,O95373,P50995,P78310,O95563,O95140,Q9NZJ7,Q96L92,P12235,O15397,Q9H2V7,Q9BRK5,P51798,P55011,Q9NPA0,Q96PC5,Q92973,Q00325,P61421,P16615,O14828,Q9Y320,Q07065,P62942,Q6P4A7,Q15758,O95067,Q96NB2,Q13190,P12236,P05023,Q7Z3B4,Q96S66,P51149,Q6N075,Q8TEM1 113 +FDA approved drug targets 0.3490368060901161 0.5274808722284979 0.5978596960044176 0.999999987766463 0.797399117938112 101 P12235,Q16836,P05067,Q16850,O75874,P20618,P21964,P55011,Q16739,P16615,P49721,P20645,P62942,P28074,Q16637,Q15758,P23786,P10253,P12236,P02786,Q14534,Q13423,Q99720,Q96QD8,P48735 25 +Human disease related genes 0.3031212791987133 0.4765536811394082 0.6336799731068363 0.999999998106727 0.797399117938112 772 O75503,P07858,O00584,P50897,Q9BQE5,P06280,P07602,P05067,P15586,P42892,Q14108,P06865,P16278,O00462,P61916,Q9H061,P11117,O75844,P54802,Q8IV08,Q9UBM7,O14773,P10619,Q16740,Q15392,Q16625,P04066,P53634,P10321,Q14574,P17900,O43505,P23786,P10253,Q9Y487,Q8N511,O43676,P08236,Q15067,Q06136,Q99720,Q86XL3,P07686,Q9NR77,O15118,Q9NQZ5,Q92542,O00754,P48735,Q13510,Q13501,O75874,Q9Y619,P35637,Q6DKK2,Q06787,Q14126,Q2VPK5,P01889,O75787,Q9NWM8,O75845,P04439,Q14739,Q9UHX1,O14979,P04062,Q96N66,P50402,P35270,Q32P28,Q96P11,Q9H2C2,Q9NQW6,O43772,Q70HW3,O75718,Q8TAA9,P38571,Q9Y5P4,O14949,Q96CU9,O75306,O95630,Q8NCH0,Q07021,Q96EK5,P04899,Q16836,Q9H7Z7,P11177,P53985,Q9UBX3,P08183,P22626,O96000,Q10713,P21964,P10644,O15269,O00429,O75477,Q15041,Q5XKP0,P48449,P35670,O95470,Q16637,P38159,Q9Y4P3,Q6P4Q7,Q9NPL8,P51648,P55795,Q9H6K4,Q15555,Q13423,P00367,P50995,Q9BV10,Q03164,P16435,O95140,O75569,P12235,O95831,O60879 127 +Metabolic proteins 0.321742290133174 0.4711491443609328 0.6375342324817319 0.9999999984677136 0.797399117938112 756 Q7Z7E8,Q9NWT6,Q9H773,Q92604,P07858,P07099,O15228,P50897,O43159,P06280,P48651,P07602,Q96AY3,Q16850,Q99538,P15586,Q9Y3E5,Q99496,Q8TC12,P48506,P20674,Q9BTY2,Q9NR33,P06865,P43490,P16278,O00462,P11117,Q16739,O75844,P54802,Q93050,Q8N4Q0,Q8IV08,Q9UBM7,O14773,O75964,P30520,Q9H2D1,Q9UHG3,Q8WTV0,P10619,Q8NCC3,O60725,Q15392,Q92820,P04066,P53634,P17900,O43505,P23786,P10253,Q9Y487,P02786,O43676,P08236,Q15067,Q06136,P07686,Q9Y680,O15118,Q9NQZ5,Q15904,O00754,P48735,Q13510,Q86UY6,Q8TB61,Q15375,Q9UDW1,Q9UMR5,Q8NBQ5,Q969T7,O75874,P67812,Q96G23,Q9Y619,P35790,O95628,Q8N2A8,O14975,Q9NWM8,O75845,Q14739,Q9H7B4,Q9BWD1,P05026,P04062,P30519,Q96N66,Q6ZT21,P35270,Q96P11,Q9BTX1,O43772,Q70HW3,Q9H9T3,P38571,Q9Y5P4,O14949,O75306,O95630,Q8NCH0,Q9Y6M7,Q96QD8,P48163,Q16836,Q9H7Z7,Q9HA64,Q13126,P11177,P55786,P53985,P09960,Q14012,Q9UBX3,P08195,P08183,Q9HCL2,O96000,P49189,Q10713,P21964,P10644,O15269,O00429,Q99735,Q99808,Q9BV57,Q6P1A2,P48449,O95470,Q10472,Q9Y5B8,P24539,Q9Y305,P51648,Q8N6G5,Q8NBX0,Q53GQ0,O14880,P13674,Q14534,Q13423,P00367,Q9BYT8,Q9BV10,Q03164,P16435,P30154,O95563,Q99956,P12235,O15270,Q9NZJ6,Q9BRR6,P83916,Q8N2K0,Q96IX5,P14174,P55011,Q00325,P61421,P36551,P16615,O60502,Q9BT22,P62942,Q13308,Q8IVS2,P09601,O43674,O00411,Q15165,Q15758,Q14914,Q10471,P37268,P25325,Q9UHQ9,Q9NPH0,Q96K76,Q15005,Q9UIJ7,Q9NVV4,P12236,O43252,P05023,Q7Z3B4,Q9H000,Q9UKN8,P40939,Q9Y5P6,Q8NBN7,Q15185,Q8TEM1 196 +Disease related genes 0.2820552091374145 0.3243292525668395 0.745688775253097 0.9999999999987196 0.877280912062467 850 O75503,P07858,O00584,P50897,P06280,P07602,P05067,P15586,P42892,Q14108,P06865,P16278,O00462,P61916,Q9H061,P11117,O75844,P54802,Q8IV08,Q9UBM7,O14773,Q9H2D1,P10619,Q16740,Q15392,Q16625,P04066,P53634,P10321,P28070,Q14574,P17900,O43505,Q99523,P23786,P10253,Q9Y487,P02786,Q8N511,O43676,P08236,Q15067,Q06136,Q99720,Q86XL3,P07686,O15118,Q92542,Q15904,O00754,P48735,Q13510,Q13501,O75874,Q01844,Q9Y619,P35637,Q6DKK2,Q06787,Q14126,Q2VPK5,P01889,O75787,Q9NWM8,O75845,P04439,Q14739,Q9UHX1,Q92804,O14979,P04062,Q96N66,P50402,P35270,Q32P28,Q96P11,Q9H2C2,Q9NQW6,O43772,Q70HW3,O75718,Q9H9T3,Q8TAA9,P38571,Q9Y5P4,O14949,Q96CU9,O75306,O95630,Q8NCH0,Q07021,Q96EK5,Q16836,Q13126,P11177,P53985,P08183,P22626,Q10713,P21964,P10644,O15269,O00429,O75477,Q15041,Q5XKP0,P48449,P35670,O95470,P51114,Q16637,P38159,Q92733,Q9Y4P3,Q6P4Q7,Q9NPL8,P51648,Q96A33,P55795,Q9H6K4,Q15555,Q13423,P00367,P50995,Q9BV10,Q03164,P16435,O95140,O75569,P12235,O95831,O60879 132 +Enzymes 0.2908579646972939 0.2089917877026108 0.8344546495298364 0.9999999999999998 0.9271718328109292 775 Q9NWT6,Q9H773,P07858,Q9HB40,O00584,P50897,P06280,Q16850,Q99538,P15586,P42892,Q9BTY2,Q8TCT8,O00115,Q9NUJ1,P06865,O75976,P43490,P16278,O00462,Q96FW1,P11117,Q16739,O75844,P54802,P49721,Q8N4Q0,Q8IV08,Q9UBM7,O14773,P30520,Q9UHG3,P10619,Q8NCC3,Q9UIQ6,Q16740,O60725,Q15392,Q92820,P42785,Q9H3G5,P04066,P53634,P28070,P23786,P10253,P02786,P08236,Q15067,Q06136,P07686,Q9Y680,O00754,P48735,Q13510,Q86UY6,Q15375,Q6ZRP7,Q5JRX3,Q8NBQ5,Q969T7,O75874,P67812,Q96G23,P35790,P20618,O95628,O14975,Q9NWM8,O75845,Q14739,Q9H7B4,Q9BWD1,P04062,P30519,P11233,P35270,Q32P28,P49720,P38571,P61225,O75306,O95630,Q8NCH0,Q8NB78,P28072,P48163,Q16836,Q9H7Z7,Q9HA64,Q13126,P11177,P55786,O95881,P09960,Q14012,P08183,Q9HCL2,Q9NZ08,P49189,Q10713,P21964,O15269,O00429,Q99735,Q9BV57,Q6P1A2,P48449,P35670,O43847,O95470,Q10472 112 diff --git a/protein_atlas_protein_class/selections.json b/protein_atlas_protein_class/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..3f6898e296ccec024f843a725b49a95c25fbc2ec --- /dev/null +++ b/protein_atlas_protein_class/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["Blood group antigen proteins", "CD markers", "Cancer-related genes", "Candidate cardiovascular disease genes", "Citric acid cycle related proteins", "Disease related genes", "Enzymes", "FDA approved drug targets", "Human disease related genes", "Metabolic proteins", "Plasma proteins", "Potential drug targets", "Predicted intracellular proteins", "Predicted membrane proteins", "Predicted secreted proteins", "RAS pathway related proteins", "RNA polymerase related proteins", "Ribosomal proteins", "Transcription factors", "Transporters"], "available_proteins": ["AAAS", "AAMP", "AARS", "AARS2", "AASDHPPT", "AATF", "ABCB1", "ABCB7", "ABCD3", "ABCE1", "ABCF1", "ABCF2", "ABCF3", "ABHD10", "ABHD12", "ABHD14B", "ABHD6", "ABI1", "ABRAXAS2", "ACAA2", "ACACA", "ACACB", "ACAD9", "ACADM", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACIN1", "ACLY", "ACO2", "ACOT13", "ACOT7", "ACOT9", "ACOX1", "ACOX3", "ACP1", "ACP2", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN2", "ACTN4", "ACTR1A", "ACTR2", "ACTR3", "ADAR", "ADD1", "ADD3", "ADH5", "ADI1", "ADK", "ADNP", "ADPGK", "ADPRHL2", "ADRM1", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGK", "AGL", "AGPAT1", "AGPS", "AHCY", "AHCYL1", "AHNAK", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AK3", "AKAP1", "AKAP12", "AKAP13", "AKAP17A", "AKAP8", "AKAP8L", "AKR1A1", "AKR1B1", "AKR7A2", "AKT2", "ALDH16A1", "ALDH18A1", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALG1", "ALG12", "ALKBH5", "AMOT", "ANAPC1", "ANAPC10", "ANAPC5", "ANAPC7", "ANKLE2", "ANKRD17", "ANLN", "ANO10", "ANP32A", "ANP32B", "ANXA1", "ANXA11", "ANXA2", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP1M1", "AP1S2", "AP2A1", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "APEH", "APEX1", "APEX2", "API5", "APLP2", "APMAP", "APOL2", "APOO", "APOOL", "APP", "APRT", "AQR", "ARCN1", "ARF4", "ARFGAP1", "ARFGAP2", "ARFIP1", "ARFIP2", "ARHGAP17", "ARHGDIA", "ARHGEF2", "ARID1A", "ARID3B", "ARIH1", "ARIH2", "ARL1", "ARL10", "ARL2", "ARL3", "ARL6IP1", "ARL6IP5", "ARMC10", "ARMC6", "ARMCX3", "ARMT1", "ARPC1A", "ARPC2", "ARPC3", "ARPC4", "ARSA", "ARV1", "ASAH1", "ASCC2", "ASCC3", "ASH2L", "ASNA1", "ASNS", "ASPH", "ASPSCR1", "ASRGL1", "ATAD1", "ATAD3A", "ATAD3B", "ATG3", "ATIC", "ATL2", "ATP13A1", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2C1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6", "ATP6AP1", "ATP6AP2", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1D", "ATP6V1E1", "ATP6V1G1", "ATP6V1H", "ATP7B", "ATPAF1", "ATPIF1", "ATXN10", "ATXN2L", "AUP1", "AURKA", "B4GAT1", "BAG3", "BAG5", "BAG6", "BAIAP2", "BANF1", "BAZ1A", "BAZ1B", "BCAP31", "BCAS3", "BCCIP", "BCLAF1", "BCS1L", "BICD2", "BIRC6", "BLMH", "BLVRA", "BMS1", "BOLA2*", "BOP1", "BPNT1", "BPTF", "BRAP", "BRAT1", "BRD1", "BRD2", "BRIX1", "BSG", "BTAF1", "BTF3", "BUB1B", "BUB3", "BUD23", "BUD31", "BYSL", "BZW1", "BZW2", "C12orf73", "C17orf75", "C19orf70", "C1QBP", "C1orf122", "C1orf123", "C1orf35", "C5orf15", "C5orf51", "C8orf33", "CAB39", "CACUL1", "CACYBP", "CAD", "CALCOCO1", "CALD1", "CALM3", "CALR", "CALU", "CAMK1", "CAMK2G", "CAND1", "CAND2", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPNS1", "CAPRIN1", "CAPZA1", "CAPZA2", "CAPZB", "CARM1", "CARS", "CASK", "CAST", "CBL", "CBR1", "CBX1", "CBX2", "CBX3", "CBX5", "CCAR1", "CCAR2", "CCDC124", "CCDC138", "CCDC22", "CCDC47", "CCDC6", "CCDC86", "CCNB1", "CCNB2", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2AP", "CDC123", "CDC20", "CDC23", "CDC25C", "CDC27", "CDC34", "CDC37", "CDC40", "CDC42", "CDC5L", "CDC73", "CDCA8", "CDK1", "CDK2", "CDK4", "CDK5", "CDK5RAP3", "CDK6", "CDKN2AIP", "CDV3", "CDX2", "CEBPZ", "CENPF", "CENPP", "CEP55", "CEPT1", "CERS2", "CETN2", "CFAP20", "CFL1", "CFL2", "CHAC2", "CHAF1A", "CHAF1B", "CHAMP1", "CHCHD3", "CHD4", "CHERP", "CHID1", "CHKA", "CHM", "CHMP2A", "CHMP2B", "CHMP7", "CHORDC1", "CHRAC1", "CHST14", "CHUK", "CIAPIN1", "CIP2A", "CIRBP", "CISD2", "CIZ1", "CKAP2", "CKAP4", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLASP2", "CLCC1", "CLCN3", "CLCN7", "CLGN", "CLIC1", "CLIC4", "CLINT1", "CLIP1", "CLN5", "CLNS1A", "CLPB", "CLPP", "CLPTM1", "CLPTM1L", "CLPX", "CLTC", "CLUH", "CMAS", "CMPK1", "CMTR1", "CNDP2", "CNN2", "CNN3", "CNNM4", "CNOT1", "CNOT2", "CNOT3", "CNOT4", "CNOT7", "CNOT9", "CNP", "CNPY2", "COIL", "COL4A3BP", "COLEC12", "COLGALT1", "COMMD2", "COMT", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS7A", "COPS7B", "COPS8", "COPZ1", "COQ3", "COQ8A", "COQ9", "CORO1A", "CORO1C", "CORO7", "COTL1", "COX2", "COX4I1", "COX5A", "COX6C", "CPD", "CPNE1", "CPNE3", "CPOX", "CPSF1", "CPSF3", "CPSF6", "CPSF7", "CPT2", "CPVL", "CRK", "CRKL", "CRNKL1", "CRTAP", "CRYZ", "CS", "CSDE1", "CSE1L", "CSGALNACT2", "CSK", "CSNK1A1", "CSNK2A1", "CSNK2A2", "CSNK2B", "CSTB", "CSTF1", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTBS", "CTH", "CTNNA1", "CTNNAL1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTPS2", "CTSA", "CTSB", "CTSC", "CTTN", "CTU2", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CWF19L1", "CXADR", "CXorf56", "CXorf57", "CYB5B", "CYB5D2", "CYB5R1", "CYB5R3", "CYC1", "CYFIP1", "CYP20A1", "CYP51A1", "DAP3", "DARS", "DARS2", "DAZAP1", "DBN1", "DBNL", "DCAF1", "DCAF7", "DCAKD", "DCD", "DCPS", "DCTN1", "DCTN2", "DCTN3", "DCTN4", "DCTPP1", "DCUN1D4", "DCXR", "DDB1", "DDI2", "DDOST", "DDRGK1", "DDT", "DDX1", "DDX10", "DDX17", "DDX18", "DDX20", "DDX21", "DDX23", "DDX24", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX50", "DDX51", "DDX52", "DDX54", "DDX56", "DDX6", "DEK", "DENR", "DERL1", "DFFA", "DHCR24", "DHCR7", "DHFR", "DHRS1", "DHRS7", "DHX15", "DHX16", "DHX29", "DHX30", "DHX36", "DHX37", "DHX8", "DHX9", "DIABLO", "DIAPH1", "DIAPH2", "DIAPH3", "DIDO1", "DIEXF", "DIMT1", "DIS3", "DKC1", "DLAT", "DLD", "DLST", "DNA2", "DNAAF5", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC2", "DNAJC3", "DNAJC7", "DNAJC8", "DNAJC9", "DNASE2", "DNM1L", "DNM2", "DNMT1", "DNPH1", "DNTTIP2", "DOCK7", "DOHH", "DPH2", "DPH5", "DPM1", "DPP3", "DPP9", "DPY30", "DPYSL2", "DPYSL5", "DR1", "DRG1", "DRG2", "DSC1", "DSC3", "DSG2", "DSP", "DST", "DSTN", "DTYMK", "DUSP12", "DUSP3", "DUSP9", "DUT", "DYNC1H1", "DYNC1LI1", "DYNC1LI2", "DYNC2H1", "DYNLL1", "EBNA1BP2", "ECD", "ECE1", "ECH1", "ECHS1", "ECI1", "ECI2", "ECSIT", "EDC3", "EDC4", "EDF1", "EDRF1", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EFHD1", "EFL1", "EFTUD2", "EHD1", "EHD4", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2D", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A3", "EIF4B", "EIF4E", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "ELAC2", "ELAVL1", "ELMO2", "ELMOD2", "ELOA", "ELOB", "ELOC", "ELP1", "ELP2", "ELP3", "ELP4", "EMC1", "EMC2", "EMC7", "EMD", "EMG1", "ENAH", "ENDOD1", "ENO1", "ENO2", "ENSA", "EPB41", "EPB41L2", "EPB41L5", "EPDR1", "EPHA7", "EPHX1", "EPHX2", "EPPK1", "EPRS", "EPS15", "EPS15L1", "ERAL1", "ERAP1", "ERCC2", "ERG28", "ERGIC3", "ERH", "ERI1", "ERLIN1", "ERLIN2", "ERMP1", "ERO1A", "ERP29", "ESD", "ESF1", "ESYT1", "ETF1", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXO1", "EXOC2", "EXOC3", "EXOC5", "EXOC7", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "EZR", "FAF1", "FAF2", "FAH", "FAHD1", "FAM114A2", "FAM129B", "FAM162A", "FAM192A", "FAM208A", "FAM213A", "FAM49B", "FAM8A1", "FAM98B", "FANCI", "FAR1", "FARSA", "FARSB", "FASN", "FBL", "FBXO22", "FBXO7", "FCGRT", "FDFT1", "FDPS", "FECH", "FEN1", "FGFR1OP", "FH", "FHOD1", "FIP1L1", "FIS1", "FKBP10", "FKBP14", "FKBP1A", "FKBP3", "FKBP4", "FKBP5", "FKBP7", "FKBP8", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FMR1", "FN3KRP", "FNTB", "FOXRED1", "FRG1", "FSCN1", "FTO", "FTSJ3", "FUBP1", "FUBP3", "FUCA1", "FUCA2", "FUNDC2", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GADD45GIP1", "GAK", "GALK1", "GALM", "GALNT1", "GALNT2", "GALNT7", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GBA", "GBF1", "GCAT", "GCDH", "GCFC2", "GCLC", "GCLM", "GCN1", "GDI1", "GDI2", "GDPD1", "GEMIN4", "GEMIN5", "GET4", "GFM1", "GFPT1", "GGCT", "GGCX", "GGH", "GGNBP2", "GHDC", "GHITM", "GIGYF2", "GINS3", "GINS4", "GLA", "GLB1", "GLDC", "GLG1", "GLMN", "GLO1", "GLOD4", "GLRX", "GLRX3", "GLRX5", "GLS", "GLUD1", "GLYR1", "GM2A", "GMFB", "GMPPB", "GMPS", "GNA13", "GNAI1", "GNAI2", "GNAI3", "GNL1", "GNL2", "GNL3", "GNL3L", "GNPAT", "GNPDA1", "GNS", "GOLGA3", "GOLGB1", "GOLIM4", "GOLT1B", "GOPC", "GORASP2", "GOT1", "GOT2", "GPAM", "GPATCH11", "GPD2", "GPI", "GPKOW", "GPR107", "GPR108", "GPS1", "GRB2", "GRHPR", "GRIPAP1", "GRPEL1", "GRSF1", "GRWD1", "GSK3B", "GSPT1", "GSR", "GSS", "GSTK1", "GSTM3", "GSTO1", "GSTZ1", "GTF2I", "GTF3C1", "GTF3C2", "GTF3C3", "GTF3C4", "GTPBP1", "GTPBP10", "GTPBP3", "GTPBP4", "GUF1", "GUSB", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACD3", "HACL1", "HADH", "HADHA", "HADHB", "HAT1", "HAUS3", "HAUS5", "HAUS8", "HBS1L", "HCCS", "HCFC1", "HDAC2", "HDGF", "HDGFL2", "HDHD2", "HDHD5", "HDLBP", "HEATR1", "HEATR3", "HEBP1", "HEBP2", "HECTD1", "HECTD3", "HELLS", "HEXA", "HEXB", "HIBADH", "HIBCH", "HIF1AN", "HIGD2A", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HLTF", "HM13", "HMBS", "HMCES", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMGCS1", "HMGN2", "HMOX1", "HMOX2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPLL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HNRNPUL2", "HP1BP3", "HPF1", "HPRT1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSDL1", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA13", "HSPA14", "HSPA1B", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPB1", "HSPBP1", "HSPD1", "HSPE1", "HSPH1", "HTATIP2", "HUWE1", "HYOU1", "IARS", "IARS2", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDI1", "IFT27", "IGBP1", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IK", "IKBIP", "ILF2", "ILF3", "ILKAP", "ILVBL", "IMMT", "IMP4", "IMPACT", "IMPDH1", "IMPDH2", "INA", "INCENP", "INTS11", "INTS14", "INTS7", "INTS9", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IRF2BPL", "IRGQ", "IRS4", "ISCU", "ISOC1", "IST1", "ISYNA1", "ITGB1", "ITM2C", "ITPA", "IVD", "JPT2", "JUP", "KARS", "KCTD12", "KCTD5", "KDELC2", "KDELR1", "KDM1A", "KDM1B", "KDM3B", "KDSR", "KHDRBS1", "KHSRP", "KIAA0319L", "KIAA0368", "KIAA0391", "KIAA1147", "KIAA2013", "KIF11", "KIF15", "KIF18B", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF4A", "KIF5B", "KIF7", "KIFBP", "KIFC1", "KLC1", "KMT2A", "KNTC1", "KPNA1", "KPNA2", "KPNA3", "KPNB1", "KRI1", "KRR1", "KTN1", "LAMP1", "LAMTOR1", "LANCL2", "LAP3", "LARP1", "LARP4", "LARP4B", "LARS", "LARS2", "LAS1L", "LASP1", "LBR", "LCLAT1", "LDAH", "LDHA", "LDHB", "LEMD2", "LEMD3", "LETM1", "LGALS3", "LGALS3BP", "LGMN", "LIG1", "LIG3", "LIMA1", "LIPA", "LLGL1", "LMAN1", "LMAN2", "LMNA", "LMNB1", "LMNB2", "LNPEP", "LONP1", "LPCAT1", "LPCAT3", "LPGAT1", "LRBA", "LRPPRC", "LRRC40", "LRRC47", "LRRC57", "LRRC59", "LRWD1", "LSM12", "LSM14B", "LSM2", "LSM6", "LSM7", "LSS", "LTA4H", "LTN1", "LTV1", "LUC7L2", "LUC7L3", "LYAR", "LYPLA1", "M6PR", "MACF1", "MAD2L1", "MAGED2", "MAN2A1", "MAN2B1", "MANBA", "MANF", "MAP1B", "MAP1S", "MAP2K1", "MAP4", "MAPK1", "MAPRE1", "MAPRE2", "MARC1", "MARCKS", "MARS", "MAT2A", "MAT2B", "MATR3", "MAVS", "MBD3", "MBOAT7", "MCAT", "MCCC1", "MCCC2", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCMBP", "MCU", "MDC1", "MDH1", "MDH2", "MDN1", "ME1", "MECP2", "MED1", "MED21", "MED23", "MED24", "MED25", "MED4", "MFN2", "MFSD10", "MFSD3", "MFSD5", "MGEA5", "MGST2", "MGST3", "MIA2", "MICU1", "MID1", "MIF", "MINDY3", "MINPP1", "MIPEP", "MKI67", "MKRN2", "MLEC", "MMGT1", "MMS19", "MOGS", "MORF4L1", "MORF4L2", "MOSPD2", "MOV10", "MPC2", "MPHOSPH10", "MPHOSPH6", "MPI", "MPP6", "MPRIP", "MPST", "MPV17L2", "MRE11", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL14", "MRPL15", "MRPL19", "MRPL21", "MRPL28", "MRPL3", "MRPL37", "MRPL38", "MRPL39", "MRPL40", "MRPL44", "MRPL46", "MRPL47", "MRPL48", "MRPL49", "MRPL50", "MRPL53", "MRPL9", "MRPS11", "MRPS2", "MRPS22", "MRPS23", "MRPS25", "MRPS27", "MRPS28", "MRPS30", "MRPS31", "MRPS33", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRPS9", "MRTO4", "MSH2", "MSH3", "MSH6", "MSI2", "MSN", "MSTO1", "MTA1", "MTA2", "MTAP", "MTBP", "MTCH1", "MTCH2", "MTDH", "MTHFD1L", "MTHFD2", "MTMR2", "MTMR6", "MTOR", "MTPAP", "MTPN", "MTR", "MTX1", "MTX2", "MVK", "MYBBP1A", "MYCBP", "MYDGF", "MYG1", "MYH10", "MYH14", "MYH9", "MYL6", "MYO1B", "MYO1C", "MYO1D", "MYO6", "NAA15", "NAA25", "NAA40", "NAA50", "NAE1", "NAF1", "NAGLU", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NAPG", "NARS", "NASP", "NAT10", "NAXE", "NBN", "NCAPD2", "NCAPG", "NCAPH", "NCBP1", "NCDN", "NCKAP1", "NCKIPSD", "NCL", "NCLN", "NCOA5", "NCSTN", "NDC1", "NDRG3", "NDUFA10", "NDUFA3", "NDUFA4", "NDUFA5", "NDUFA7", "NDUFA9", "NDUFAF4", "NDUFAF7", "NDUFB10", "NDUFB3", "NDUFB4", "NDUFB5", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS6", "NDUFS7", "NDUFV1", "NDUFV2", "NECAP1", "NECAP2", "NEFL", "NEFM", "NEK9", "NELFA", "NELFCD", "NELFE", "NEMF", "NENF", "NES", "NFU1", "NHLRC2", "NHP2", "NIFK", "NIPBL", "NKRF", "NLE1", "NLN", "NMD3", "NME1", "NME6", "NME7", "NMT1", "NNT", "NOB1", "NOC2L", "NOC3L", "NOC4L", "NOL10", "NOL11", "NOL6", "NOL7", "NOL9", "NOLC1", "NOM1", "NONO", "NOP14", "NOP2", "NOP53", "NOP56", "NOP58", "NOSIP", "NPC1", "NPC2", "NPEPPS", "NPLOC4", "NPM1", "NRDC", "NRP1", "NSA2", "NSD2", "NSDHL", "NSF", "NSFL1C", "NSUN2", "NSUN5", "NT5C2", "NT5C3B", "NT5DC1", "NT5DC2", "NTHL1", "NTMT1", "NTPCR", "NUB1", "NUBP2", "NUCB1", "NUCB2", "NUCKS1", "NUDC", "NUDCD2", "NUDT1", "NUDT12", "NUDT21", "NUDT5", "NUF2", "NUFIP2", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP160", "NUP188", "NUP205", "NUP210", "NUP214", "NUP37", "NUP43", "NUP50", "NUP54", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NUPL2", "NVL", "NXF1", "NXN", "OAT", "OCIAD1", "OCLN", "OCRL", "OGDH", "OGT", "OLA1", "OPA1", "OPA3", "OSBP", "OSBPL8", "OSBPL9", "OSGEP", "OTUB1", "OTULIN", "OXA1L", "OXSR1", "P3H1", "P3H4", "P4HA1", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PAF1", "PAFAH1B1", "PAFAH1B2", "PAFAH1B3", "PAICS", "PAK1", "PAK1IP1", "PAK2", "PANK4", "PAPOLA", "PAPSS1", "PARK7", "PARN", "PARP1", "PATL1", "PBDC1", "PBK", "PBRM1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCK2", "PCLAF", "PCM1", "PCMT1", "PCNA", "PCNP", "PCYOX1", "PDAP1", "PDCD11", "PDCD4", "PDCD5", "PDCD6", "PDCD6IP", "PDCL3", "PDE12", "PDE6D", "PDHA1", "PDHB", "PDIA3", "PDIA4", "PDIA6", "PDK1", "PDK3", "PDLIM1", "PDLIM3", "PDLIM5", "PDLIM7", "PDPR", "PDRG1", "PDS5A", "PDS5B", "PDXDC1", "PDXK", "PEBP1", "PECR", "PEF1", "PELO", "PELP1", "PEPD", "PES1", "PEX14", "PEX19", "PFAS", "PFDN2", "PFDN4", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGGT1B", "PGK1", "PGLS", "PGM1", "PGM2", "PGM3", "PGP", "PGRMC1", "PGRMC2", "PHB", "PHB2", "PHF14", "PHF5A", "PHF6", "PHF8", "PHGDH", "PHIP", "PHKA1", "PICALM", "PIGT", "PIH1D1", "PIK3C2A", "PIK3R4", "PIN1", "PIN4", "PIP4K2C", "PIR", "PISD", "PITHD1", "PITPNB", "PITRM1", "PKM", "PKMYT1", "PKN2", "PLA2G15", "PLAA", "PLBD2", "PLCG1", "PLD3", "PLD6", "PLEC", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLRG1", "PLS3", "PM20D2", "PMPCA", "PMPCB", "PNN", "PNO1", "PNP", "PNPT1", "PODXL", "POGZ", "POLA1", "POLA2", "POLD1", "POLD2", "POLD3", "POLDIP2", "POLDIP3", "POLE", "POLE3", "POLE4", "POLR1A", "POLR1B", "POLR1E", "POLR2B", "POLR2C", "POLR2G", "POLR3A", "POLR3C", "POLRMT", "PON2", "POP1", "POR", "PPA1", "PPA2", "PPAN", "PPAT", "PPFIA1", "PPHLN1", "PPIB", "PPID", "PPIF", "PPIG", "PPIH", "PPIL4", "PPM1G", "PPME1", "PPP1CA", "PPP1CB", "PPP1R10", "PPP1R7", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP4C", "PPP4R1", "PPP5C", "PPP6C", "PPT1", "PPT2", "PQBP1", "PRAF2", "PRCC", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PREP", "PREPL", "PRIM1", "PRIM2", "PRKAG1", "PRKAR1A", "PRKAR2A", "PRKCD", "PRKCSH", "PRKDC", "PRKRA", "PRMT1", "PRMT3", "PRMT5", "PRMT9", "PRPF19", "PRPF3", "PRPF31", "PRPF38B", "PRPF39", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPS1", "PRPSAP1", "PRPSAP2", "PRRC1", "PRRC2A", "PRRC2C", "PSAP", "PSAT1", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD6", "PSMD7", "PSMD8", "PSME1", "PSME2", "PSME3", "PSME4", "PSMF1", "PSMG1", "PSMG2", "PSPC1", "PTBP1", "PTBP2", "PTCD1", "PTCD3", "PTDSS1", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK7", "PTPA", "PTPN1", "PTPN11", "PTRH2", "PTRHD1", "PUF60", "PUM3", "PURA", "PUS1", "PUS7", "PWP1", "PWP2", "PXMP2", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QDPR", "QKI", "QSOX2", "RAB10", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB21", "RAB23", "RAB24", "RAB2A", "RAB35", "RAB3GAP2", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RAB8A", "RABEPK", "RABGAP1", "RABGGTA", "RABL6", "RAC1", "RACGAP1", "RACK1", "RAD21", "RAD23A", "RAD23B", "RAD50", "RAE1", "RAI14", "RALA", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP9", "RANGAP1", "RANGRF", "RAP2B", "RAPGEF2", "RARS", "RARS2", "RAVER1", "RB1", "RBBP4", "RBBP6", "RBBP7", "RBM10", "RBM12", "RBM12B", "RBM14", "RBM17", "RBM19", "RBM22", "RBM25", "RBM26", "RBM27", "RBM28", "RBM3", "RBM34", "RBM39", "RBM4", "RBM5", "RBM8A", "RBMX", "RCC1", "RCC2", "RCL1", "RCN1", "RCN2", "RCOR1", "RDH11", "RDH13", "RDX", "RECQL", "REEP4", "REEP5", "RELA", "REPS1", "RER1", "RETSAT", "REXO4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RHEB", "RHOT1", "RHOT2", "RIDA", "RIF1", "RINT1", "RIOK2", "RIOX1", "RMC1", "RMDN3", "RNASEH2A", "RNASET2", "RNF2", "RNF40", "RNH1", "RNPEP", "ROCK1", "ROCK2", "RPA1", "RPA2", "RPAP1", "RPAP3", "RPF2", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPN1", "RPN2", "RPP30", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RRBP1", "RRM1", "RRM2", "RRP1", "RRP12", "RRP15", "RRP1B", "RRP8", "RRS1", "RSF1", "RSL1D1", "RSL24D1", "RSU1", "RTCB", "RTFDC1", "RTN3", "RTN4", "RTRAF", "RUFY1", "RUVBL1", "RUVBL2", "RWDD1", "S100A10", "S100A11", "S100A13", "SACM1L", "SAE1", "SAFB", "SAFB2", "SAMHD1", "SAMM50", "SAP130", "SAP18", "SAP30BP", "SAR1A", "SARNP", "SARS", "SARS2", "SART1", "SART3", "SASS6", "SBDS", "SC5D", "SCAMP2", "SCAMP3", "SCARB1", "SCARB2", "SCCPDH", "SCD", "SCFD1", "SCML2", "SCO1", "SCO2", "SCP2", "SCPEP1", "SCRIB", "SCRN1", "SDCBP", "SDE2", "SDF4", "SDHA", "SDHB", "SDR39U1", "SEC11A", "SEC16A", "SEC22B", "SEC23A", "SEC23IP", "SEC24A", "SEC24B", "SEC24C", "SEC24D", "SEC31A", "SEC61A1", "SEC61B", "SEC61G", "SEC62", "SEC63", "SEH1L", "SEL1L", "SENP3", "SEPHS1", "SEPT2", "SEPT7", "SEPT9", "SERBP1", "SERPINB6", "SERPINH1", "SET", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFSWAP", "SFXN1", "SFXN2", "SFXN4", "SGPL1", "SGTA", "SH3BGRL3", "SH3GL1", "SH3GLB1", "SH3PXD2B", "SHCBP1", "SHMT1", "SHMT2", "SHOC2", "SIGMAR1", "SIL1", "SIN3A", "SKIV2L", "SKIV2L2", "SKP1", "SKP2", "SLC12A2", "SLC12A9", "SLC16A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A17", "SLC25A19", "SLC25A20", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A4", "SLC25A42", "SLC25A44", "SLC25A5", "SLC25A6", "SLC27A2", "SLC27A4", "SLC29A1", "SLC30A5", "SLC35B2", "SLC35F1", "SLC35F2", "SLC38A2", "SLC3A2", "SLC4A1AP", "SLC4A7", "SLC9A3R1", "SLFN11", "SLIRP", "SLIT2", "SLK", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC6", "SMCHD1", "SMN1*", "SMNDC1", "SMPD4", "SMU1", "SMYD3", "SND1", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPC", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNW1", "SNX1", "SNX2", "SNX27", "SNX3", "SNX5", "SNX6", "SNX9", "SOD2", "SON", "SORT1", "SPAG9", "SPART", "SPATA5", "SPATA5L1", "SPC25", "SPCS2", "SPEN", "SPNS1", "SPPL2A", "SPR", "SPTAN1", "SPTBN1", "SPTBN2", "SPTLC1", "SPTLC2", "SQLE", "SQSTM1", "SRCAP", "SREK1", "SRI", "SRM", "SRP14", "SRP54", "SRP68", "SRP72", "SRP9", "SRPK1", "SRPRA", "SRPRB", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF2", "SRSF3", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSNA1", "SSR1", "SSR4", "SSRP1", "STAG2", "STAM", "STAMBP", "STARD3", "STARD3NL", "STARD7", "STAT1", "STAT3", "STAU1", "STAU2", "STIP1", "STMN1", "STOM", "STOML2", "STRAP", "STRBP", "STT3A", "STT3B", "STUB1", "STX18", "STX4", "STX5", "STX7", "STX8", "STXBP3", "STXBP4", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGP2", "SUGT1", "SUN1", "SUPT16H", "SUPT5H", "SUPT6H", "SUPV3L1", "SURF4", "SURF6", "SUZ12", "SYAP1", "SYMPK", "SYNCRIP", "SYNE2", "SYNGR2", "SYS1", "TACC3", "TACO1", "TAF15", "TAF6L", "TAGLN2", "TALDO1", "TAMM41", "TARDBP", "TARS", "TARS2", "TBC1D13", "TBC1D15", "TBC1D4", "TBC1D9B", "TBCA", "TBCB", "TBCD", "TBCE", "TBL2", "TBL3", "TBRG4", "TCEA1", "TCERG1", "TCOF1", "TCP1", "TDP2", "TDRKH", "TECR", "TELO2", "TERF2IP", "TEX10", "TEX264", "TFAM", "TFCP2", "TFG", "TFRC", "THADA", "THOC1", "THOC2", "THOC3", "THOC6", "THOP1", "THRAP3", "THUMPD1", "THUMPD3", "THYN1", "TIAL1", "TIGAR", "TIMM13", "TIMM17A", "TIMM17B", "TIMM23", "TIMM44", "TIMM50", "TIMM8A", "TIMM8B", "TIMMDC1", "TIPRL", "TJP1", "TK1", "TKT", "TLCD1", "TLN1", "TM9SF3", "TM9SF4", "TMA7", "TMCO1", "TMED10", "TMED2", "TMED5", "TMED7", "TMED9", "TMEM109", "TMEM11", "TMEM126A", "TMEM14C", "TMEM160", "TMEM192", "TMEM199", "TMEM205", "TMEM209", "TMEM214", "TMEM230", "TMEM259", "TMEM33", "TMEM43", "TMEM65", "TMEM97", "TMOD3", "TMPPE", "TMSB4X", "TMTC3", "TMX1", "TMX2", "TMX4", "TNPO1", "TNPO3", "TOE1", "TOLLIP", "TOM1", "TOMM20", "TOMM22", "TOMM34", "TOMM40", "TOMM5", "TOMM70", "TOP1", "TOP2A", "TOP2B", "TOR1AIP1", "TOX4", "TP53", "TP53BP2", "TPD52", "TPD52L2", "TPI1", "TPM1", "TPM3", "TPM4", "TPP1", "TPP2", "TPR", "TPT1", "TPX2", "TRA2A", "TRA2B", "TRABD", "TRAF2", "TRAM1", "TRAP1", "TRAPPC11", "TRAPPC3", "TRAPPC4", "TRAPPC5", "TRIM21", "TRIM25", "TRIM28", "TRIM33", "TRIO", "TRIP12", "TRIP13", "TRMT10C", "TRMT1L", "TRMT6", "TROVE2", "TRUB1", "TSFM", "TSG101", "TSN", "TSNAX", "TSPAN3", "TSPAN6", "TSR1", "TTC1", "TTC19", "TTC26", "TTC37", "TTC38", "TTC4", "TTK", "TTLL12", "TTYH3", "TUBB", "TUBB2A", "TUBB2B", "TUBB4A", "TUBB4B", "TUBB6", "TUBGCP2", "TUBGCP3", "TUFM", "TWF1", "TWF2", "TXLNA", "TXLNG", "TXNDC12", "TXNDC17", "TXNDC5", "TXNDC9", "TXNL1", "TXNRD1", "TYMS", "U2AF2", "U2SURP", "UAP1", "UBA1", "UBA2", "UBA3", "UBA6", "UBAP2L", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2O", "UBE2Q1", "UBE2S", "UBE3C", "UBE4A", "UBR2", "UBR4", "UBR5", "UBR7", "UBTF", "UBXN7", "UCHL5", "UCK2", "UFC1", "UFD1", "UFL1", "UGCG", "UGDH", "UGGT1", "UGP2", "UHRF1", "UMPS", "UNC119B", "UNC45A", "UPF1", "UQCC2", "UQCR10", "UQCRC1", "UQCRC2", "UQCRQ", "URB1", "UROD", "USMG5", "USO1", "USP10", "USP11", "USP14", "USP24", "USP28", "USP34", "USP39", "USP47", "USP48", "USP5", "USP7", "USP8", "USP9X", "UTP14A", "UTP15", "UTP18", "UTP20", "UTP4", "UTP6", "UTRN", "VAMP7", "VANGL1", "VAPA", "VAPB", "VARS1", "VAT1", "VBP1", "VCL", "VCP", "VDAC1", "VDAC2", "VDAC3", "VIM", "VKORC1L1", "VMP1", "VPS16", "VPS18", "VPS26A", "VPS29", "VPS33B", "VPS35", "VPS4A", "VPS4B", "VPS51", "VPS53", "VRK1", "WAPL", "WARS", "WBP11", "WDHD1", "WDR1", "WDR12", "WDR18", "WDR3", "WDR33", "WDR36", "WDR4", "WDR41", "WDR43", "WDR5", "WDR6", "WDR61", "WDR75", "WDR77", "WDR91", "WFS1", "WIPI2", "WIZ", "WLS", "WTAP", "XAB2", "XPNPEP1", "XPNPEP3", "XPO1", "XPO4", "XPO5", "XPO7", "XPOT", "XRCC5", "XRCC6", "XRN2", "YARS", "YARS2", "YBX1", "YKT6", "YLPM1", "YME1L1", "YRDC", "YTHDC1", "YTHDC2", "YTHDF2", "YTHDF3", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2", "ZC3H11A", "ZC3H14", "ZC3H15", "ZC3H18", "ZC3H4", "ZC3HAV1", "ZCCHC11", "ZCCHC3", "ZCCHC8", "ZFR", "ZFYVE16", "ZMPSTE24", "ZMYM4", "ZNF280C", "ZNF318", "ZNF326", "ZNF638", "ZPR1", "ZW10", "ZYX"], "leading_proteins": ["ABCB1", "ABHD10", "ABHD12", "ACAT2", "ACOT9", "ACOX1", "ACP2", "ACP6", "ADI1", "ADPGK", "ADSS", "AIFM1", "AK3", "ALDH3A2", "ALDH9A1", "ALG1", "ALG12", "ANKLE2", "ANLN", "ANXA11", "APLP2", "APOL2", 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"P4HA1", "PAPSS1", "PCYOX1", "PDHB", "PGRMC1", "PGRMC2", "PITRM1", "PLA2G15", "PLD3", "PLD6", "PMPCA", "PODXL", "POLE4", "POLRMT", "PON2", "POR", "PPP2R1B", "PPT1", "PPT2", "PRAF2", "PRCC", "PRCP", "PRKAR1A", "PRKRA", "PSAP", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PTDSS1", "PTGES2", "PTGES3", "PTGR1", "PTK7", "PTRH2", "PUF60", "PXMP2", "QSOX2", "RAB7A", "RALA", "RAP2B", "RBMX", "RDH11", "RDH13", "REEP4", "REEP5", "RNASET2", "RNF2", "RRP8", "RTN3", "SC5D", "SCAMP2", "SCAMP3", "SCARB1", "SCARB2", "SCCPDH", "SCPEP1", "SDCBP", "SDF4", "SEC11A", "SFXN2", "SFXN4", "SGPL1", "SIGMAR1", "SLC12A2", "SLC16A1", "SLC1A5", "SLC25A10", "SLC25A15", "SLC25A20", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A4", "SLC25A44", "SLC25A6", "SLC27A2", "SLC29A1", "SLC30A5", "SLC35B2", "SLC35F1", "SLC35F2", "SLC38A2", "SLC3A2", "SLC4A7", "SLIT2", "SMN1*", "SMYD3", "SNX27", "SORT1", "SPCS2", "SPNS1", "SPPL2A", "SPR", "SPTLC1", "SPTLC2", "SQLE", "SQSTM1", "SRPRB", "SSR1", "STAMBP", "STARD3NL", 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0.4161874156663988 0.0001958860773813 0.0009667806496787 4.681816849264793e-05 2.099599997303824e-05 0.0045130991736668 diff --git a/protein_atlas_subcellular_location_all/metrics.json b/protein_atlas_subcellular_location_all/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..bd2faf95538ae6a2571d88366886a33ba248f908 --- /dev/null +++ b/protein_atlas_subcellular_location_all/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2644, + "annotations_size": 33, + "title": "Average number of proteins per term", + "value": 122.96969696969697 +} \ No newline at end of file diff --git a/protein_atlas_subcellular_location_all/paths.json b/protein_atlas_subcellular_location_all/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..de32b3580152caf33cb3506c7ea6d0c936299575 --- /dev/null +++ b/protein_atlas_subcellular_location_all/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/protein_atlas_subcellular_location_all/fragment/C197/C197_val_log2fc"} \ No newline at end of file diff --git a/protein_atlas_subcellular_location_all/result.tsv b/protein_atlas_subcellular_location_all/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..37f132262f782aad18af1ce5f5a6e00c8a624ac8 --- /dev/null +++ b/protein_atlas_subcellular_location_all/result.tsv @@ -0,0 +1,9 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Golgi apparatus 0.5411230384760883 2.1495957293659274 0.0315872065233981 0.6532654651543783 0.3474592717573801 145 Q6ZRP7,Q9HB40,Q8IXU6,P50897,P80303,P05067,O15260,Q8IZA0,O60637,P67812,Q9UBU6,P11717,Q5VW38,P16278,Q8NC54,Q9NWM8,P04439,Q8IYS2,Q93050,Q8N4Q0,O15127,Q9NPR9,O00461,P24390,Q92896,O43760,Q8TAD4,Q5KU26,Q99523,O75955,Q9Y5P4,Q8NCH0,Q02818,Q9HD45 34 +Lysosomes 0.5996324882043295 1.601800013208688 0.1091998401496201 0.9779834407825388 0.7207189449874929 11 P02786,Q8WTV0,Q8IY95 3 +Cell Junctions 0.4994182350914142 1.3162800274989142 0.1880800718602839 0.9989673916441374 0.7225385014331528 33 Q14126,P43490,O43657,P53985,Q16625,Q5KU26,Q14574 7 +Centriolar satellite 0.4552456104489786 1.0073008359556683 0.3137902281902467 0.9999959906161038 0.7225385014331528 22 Q86UY6,Q5T1Q4,O43169 3 +Endosomes 0.500185617476796 0.8177677833931151 0.4134897972370757 0.9999999774527356 0.8528227068014685 9 P02786 1 +Endoplasmic reticulum 0.4262941483344528 0.5674428528312194 0.570413342364122 0.9999999999992224 0.8582610818491833 179 Q14257,Q16850,O15260,O43852,Q96G23,P43307,Q92791,P35790,Q9H6H4,P21964,O15269,O75845,O75477,O43169,Q15041,Q99735,Q8IV08,Q9UBM7,Q96GC9,Q9BUN8,O95470,Q5BJF2,O60831,P50402,Q96A57,Q9H3G5,Q96KA5,P51648,Q96A33,Q8N6G5,O95197,Q5T9L3,Q00765,P13674,O96005,O00264,Q86XL3,Q9BV10,Q9Y680,Q99956,Q9P2W9 41 +Nuclear membrane 0.3473959280239989 0.2718839908268202 0.7857112211869759 1.0 0.9972488576603924 52 O75976,P50402,O00560,O15260,Q14739,Q9BTX1,P67812,Q96G23 8 +Focal adhesion sites 0.3276619143202014 0.1692107272565117 0.8656308923308531 1.0 1.0 22 Q9Y6M7,P11233,Q9Y487,Q9NR12 4 diff --git a/protein_atlas_subcellular_location_all/selections.json b/protein_atlas_subcellular_location_all/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..e26dd9bf72a1915b20d3cdddb957f6146ddb6325 --- /dev/null +++ b/protein_atlas_subcellular_location_all/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["Actin filaments", "Cell Junctions", "Centriolar satellite", "Centrosome", "Cytokinetic bridge", "Cytoplasmic bodies", "Cytosol", "Endoplasmic reticulum", "Endosomes", "Focal adhesion sites", "Golgi apparatus", "Intermediate filaments", "Kinetochore", "Lipid droplets", "Lysosomes", "Microtubule ends", "Microtubules", "Midbody", "Midbody ring", "Mitochondria", "Mitotic chromosome", "Mitotic spindle", "Nuclear bodies", "Nuclear membrane", "Nuclear speckles", "Nucleoli", "Nucleoli fibrillar center", "Nucleoli rim", "Nucleoplasm", "Peroxisomes", "Plasma membrane", "Rods & Rings", "Vesicles"], "available_proteins": ["AAAS", "AAMP", "AARS", "AARS2", "AATF", "ABCB1", "ABCB7", "ABCD3", "ABCE1", "ABCF1", "ABCF2", "ABCF3", "ABHD10", "ABHD14B", "ABHD6", "ABI1", "ABRAXAS2", "ACAA2", "ACACA", "ACAD9", "ACADM", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACIN1", "ACLY", "ACO2", "ACOT13", "ACOT7", "ACOT9", "ACOX1", "ACOX3", "ACP1", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN2", "ACTN4", "ACTR1A", "ACTR2", "ADAR", "ADD1", "ADD3", "ADI1", "ADK", "ADNP", "ADPGK", "ADPRHL2", "ADRM1", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGK", "AGL", "AGPAT1", "AGPS", "AHCY", "AHCYL1", "AHNAK", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AK3", "AKAP1", "AKAP12", "AKAP13", "AKAP17A", "AKAP8", "AKAP8L", "AKR1A1", "AKR1B1", "AKR7A2", "AKT2", "ALDH18A1", "ALDH1B1", "ALDH3A2", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALG1", "ALG12", "ALKBH5", "AMOT", "ANAPC1", "ANAPC10", "ANAPC5", "ANAPC7", 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"ESF1", "ESYT1", "ETFA", "ETFB", "EWSR1", "EXO1", "EXOC2", "EXOC3", "EXOC7", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC5", "EXOSC7", "EZR", "FAF1", "FAF2", "FAH", "FAHD1", "FAM114A2", "FAM129B", "FAM162A", "FAM192A", "FAM208A", "FAM49B", "FAM8A1", "FAM98B", "FANCI", "FAR1", "FARSA", "FARSB", "FASN", "FBL", "FBXO7", "FDFT1", "FDPS", "FEN1", "FGFR1OP", "FH", "FHOD1", "FIP1L1", "FIS1", "FKBP10", "FKBP14", "FKBP3", "FKBP4", "FKBP5", "FKBP7", "FKBP8", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FMR1", "FN3KRP", "FNTB", "FOXRED1", "FSCN1", "FTO", "FTSJ3", "FUBP1", "FUBP3", "FUCA1", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GADD45GIP1", "GAK", "GALK1", "GALM", "GALNT2", "GALNT7", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GBF1", "GCAT", "GCDH", "GCFC2", "GCLC", "GCLM", "GCN1", "GDI1", "GDI2", "GEMIN4", "GEMIN5", "GET4", "GFM1", "GFPT1", "GGNBP2", "GHITM", "GIGYF2", "GINS3", "GINS4", "GLB1", "GLDC", "GLG1", "GLMN", "GLO1", "GLOD4", "GLRX", "GLRX5", "GLS", "GLUD1", "GLYR1", "GM2A", "GMFB", "GMPS", "GNA13", "GNAI1", "GNAI2", "GNAI3", "GNL1", "GNL2", "GNL3", "GNL3L", "GNPDA1", "GOLGA3", "GOLGB1", "GOLIM4", "GOLT1B", "GOPC", "GORASP2", "GOT1", "GPAM", "GPATCH11", "GPD2", "GPI", "GPKOW", "GPR107", "GPR108", "GPS1", "GRB2", "GRHPR", "GRIPAP1", "GRPEL1", "GRSF1", "GRWD1", "GSK3B", "GSPT1", "GSR", "GSS", "GSTK1", "GSTM3", "GSTZ1", "GTF2I", "GTF3C1", "GTF3C2", "GTF3C3", "GTF3C4", "GTPBP1", "GTPBP3", "GTPBP4", "GUF1", "GUSB", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACD3", "HACL1", "HADH", "HADHA", "HADHB", "HAT1", "HAUS3", "HBS1L", "HCCS", "HCFC1", "HDAC2", "HDGF", "HDGFL2", "HDHD2", "HDHD5", "HDLBP", "HEATR1", "HEATR3", "HEBP1", "HECTD1", "HELLS", "HEXA", "HIBCH", "HIF1AN", "HIGD2A", "HIST1H1C", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLCS", "HLTF", "HM13", "HMBS", "HMCES", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMGCS1", "HMGN2", "HMOX1", "HMOX2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPLL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HNRNPUL2", "HP1BP3", "HPF1", "HPRT1", "HSD17B11", "HSD17B4", "HSDL1", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA1B", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPB1", "HSPBP1", "HSPD1", "HSPH1", "HTATIP2", "HUWE1", "IARS", "IARS2", "IDH1", "IDH2", "IDH3A", "IDH3B", "IGBP1", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IK", "IKBIP", "ILF2", "ILF3", "ILKAP", "ILVBL", "IMMT", "IMP4", "IMPACT", "IMPDH1", "IMPDH2", "INA", "INCENP", "INTS11", "INTS14", "INTS7", "INTS9", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IRF2BPL", "IRGQ", "ISCU", "ISOC1", "IST1", "ISYNA1", "ITGB1", "ITPA", "IVD", "JPT2", "JUP", "KARS", "KCTD12", "KDELC2", "KDELR1", "KDM1A", "KDM1B", "KDM3B", "KHDRBS1", "KHSRP", "KIAA0319L", "KIAA0368", "KIAA0391", "KIAA1147", "KIAA2013", "KIF11", "KIF18B", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF4A", "KIF5B", "KIFC1", "KLC1", "KMT2A", "KNTC1", "KPNA1", "KPNA2", "KPNA3", "KPNB1", "KRI1", "KRR1", "KTN1", "LAMTOR1", "LANCL2", "LAP3", "LARP1", "LARP4", "LARP4B", "LARS", "LARS2", "LAS1L", "LASP1", "LBR", "LCLAT1", "LDHA", "LDHB", "LEMD2", "LEMD3", "LETM1", "LGALS3", "LGMN", "LIG1", "LIG3", "LIMA1", "LIPA", "LMAN1", "LMNA", "LMNB1", "LMNB2", "LONP1", "LPCAT1", "LRBA", "LRPPRC", "LRRC40", "LRRC47", "LRRC57", "LRRC59", "LRWD1", "LSM12", "LSM14B", "LSM2", "LSM6", "LSM7", "LTA4H", "LTN1", "LTV1", "LUC7L2", "LUC7L3", "LYAR", "LYPLA1", "MACF1", "MAD2L1", "MAGED2", "MAN2A1", "MAN2B1", "MANBA", "MANF", "MAP1B", "MAP1S", "MAP2K1", "MAP4", "MAPK1", "MAPRE1", "MAPRE2", "MARC1", "MARCKS", "MARS", "MAT2A", "MAT2B", "MATR3", "MAVS", "MBD3", "MBOAT7", "MCAT", "MCCC1", "MCCC2", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCMBP", "MCU", "MDC1", "MDH1", "MDH2", "MDN1", "ME1", "MECP2", "MED1", "MED21", "MED23", "MED25", "MED4", "MFN2", "MFSD10", "MFSD3", "MGEA5", "MGST2", "MGST3", "MIA2", "MICU1", "MID1", "MIF", "MINDY3", "MIPEP", "MKI67", "MKRN2", "MMS19", "MOGS", "MORF4L1", "MORF4L2", "MOSPD2", "MOV10", "MPHOSPH10", "MPHOSPH6", "MPI", "MPRIP", "MPST", "MRE11", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL14", "MRPL15", "MRPL19", "MRPL21", "MRPL28", "MRPL37", "MRPL38", "MRPL39", "MRPL40", "MRPL44", "MRPL46", "MRPL47", "MRPL48", "MRPL50", "MRPL53", "MRPL9", "MRPS11", "MRPS2", "MRPS22", "MRPS23", "MRPS25", "MRPS27", "MRPS28", "MRPS31", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRPS9", "MRTO4", "MSH2", "MSH3", "MSH6", "MSI2", "MSN", "MSTO1", "MTA1", "MTA2", "MTAP", "MTBP", "MTCH2", "MTDH", "MTHFD1L", "MTHFD2", "MTMR2", "MTOR", "MTPAP", "MTPN", "MTR", "MTX1", "MTX2", "MVK", "MYBBP1A", "MYCBP", "MYG1", "MYH10", "MYH14", "MYH9", "MYO1B", "MYO1C", "MYO1D", "MYO6", "NAA15", "NAA25", "NAA40", "NAA50", "NAE1", "NAF1", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NAPG", "NARS", "NASP", "NAT10", "NAXE", "NBN", "NCAPD2", "NCAPH", "NCBP1", "NCDN", "NCKAP1", "NCKIPSD", "NCL", "NCLN", "NCOA5", "NCSTN", "NDC1", "NDUFA10", "NDUFA4", "NDUFA7", "NDUFA9", "NDUFAF4", "NDUFB4", "NDUFB5", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFV1", "NDUFV2", "NECAP1", "NECAP2", "NEFL", "NEFM", "NELFA", "NELFCD", "NELFE", "NEMF", "NES", "NFU1", "NHLRC2", "NIFK", "NIPBL", "NKRF", "NLE1", "NLN", "NMD3", "NME1", "NME6", "NME7", "NMT1", "NNT", "NOB1", "NOC2L", "NOC3L", "NOC4L", "NOL10", "NOL11", "NOL6", "NOL7", "NOL9", "NOLC1", "NOM1", "NONO", "NOP14", "NOP2", "NOP53", "NOP56", "NOP58", "NOSIP", "NPC1", "NPEPPS", "NPLOC4", "NPM1", "NRDC", "NSA2", "NSD2", "NSDHL", "NSF", "NSFL1C", "NSUN2", "NSUN5", "NT5DC1", "NTMT1", "NTPCR", "NUB1", "NUBP2", "NUCB1", "NUCB2", "NUCKS1", "NUDC", "NUDCD2", "NUDT1", "NUDT21", "NUDT5", "NUF2", "NUFIP2", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP188", "NUP37", "NUP43", "NUP50", "NUP54", "NUP62", "NUP85", "NUP88", "NUPL2", "NVL", "NXF1", "NXN", "OAT", "OCIAD1", "OCLN", "OCRL", "OGDH", "OGT", "OLA1", "OPA1", "OPA3", "OSBP", "OSBPL8", "OSBPL9", "OSGEP", "OTUB1", "OTULIN", "OXA1L", "OXSR1", "P3H1", "P3H4", "P4HA1", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PAF1", "PAFAH1B1", "PAFAH1B2", "PAFAH1B3", "PAICS", "PAK1", "PAK1IP1", "PAK2", "PANK4", "PAPOLA", "PAPSS1", "PARK7", "PARN", "PARP1", "PATL1", "PBDC1", "PBK", "PBRM1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCK2", "PCLAF", "PCM1", "PCMT1", "PCNA", "PCNP", "PDAP1", "PDCD11", "PDCD4", "PDCD5", "PDCD6", "PDCD6IP", "PDCL3", "PDHA1", "PDHB", "PDIA3", "PDIA4", "PDIA6", "PDK3", "PDLIM1", "PDLIM3", "PDLIM5", "PDLIM7", "PDPR", "PDRG1", "PDS5A", "PDS5B", "PDXDC1", "PDXK", "PEBP1", "PECR", "PEF1", "PELO", "PELP1", "PEPD", "PES1", "PEX14", "PEX19", "PFAS", "PFDN2", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PGAM1", "PGAM5", "PGD", "PGGT1B", "PGLS", "PGM1", "PGM2", "PGM3", "PGP", "PGRMC1", "PGRMC2", "PHB", "PHB2", "PHF14", "PHF5A", "PHF6", "PHF8", "PHGDH", "PHIP", "PHKA1", "PICALM", "PIH1D1", "PIK3C2A", "PIK3R4", "PIN1", "PIN4", "PIP4K2C", "PIR", "PISD", "PITPNB", "PITRM1", "PKM", "PKMYT1", "PKN2", "PLA2G15", "PLAA", "PLCG1", "PLD3", "PLEC", "PLIN3", "PLOD1", "PLOD2", "PLRG1", "PLS3", "PM20D2", "PMPCA", "PMPCB", "PNN", "PNO1", "PNP", "PNPT1", "PODXL", "POGZ", "POLA1", "POLA2", "POLD1", "POLD2", "POLD3", "POLDIP2", "POLDIP3", "POLE", "POLE3", "POLE4", "POLR1A", "POLR1B", "POLR1E", "POLR2B", "POLR2C", "POLR2G", "POLR3A", "POLR3C", "POLRMT", "POP1", "POR", "PPA1", "PPA2", "PPAT", "PPFIA1", "PPHLN1", "PPIB", "PPID", "PPIF", "PPIG", "PPIL4", "PPM1G", "PPME1", "PPP1CA", "PPP1CB", "PPP1R10", "PPP1R7", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP4C", "PPP4R1", "PPP5C", "PPT1", "PPT2", "PQBP1", "PRAF2", "PRCC", "PRCP", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PREP", "PRIM2", "PRKAG1", "PRKAR1A", "PRKCD", "PRKCSH", "PRKDC", "PRKRA", "PRMT1", "PRMT5", "PRMT9", "PRPF19", "PRPF3", "PRPF31", "PRPF39", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPS1", "PRPSAP1", "PRPSAP2", "PRRC1", "PRRC2A", "PRRC2C", "PSAP", "PSAT1", "PSIP1", "PSMA1", "PSMA4", "PSMA5", "PSMA6", "PSMB1", "PSMB2", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD12", "PSMD13", "PSMD14", "PSMD3", "PSMD4", "PSMD7", "PSMD8", "PSME1", "PSME2", "PSME3", "PSME4", "PSMF1", "PSMG1", "PSMG2", "PSPC1", "PTBP1", "PTBP2", "PTCD1", "PTCD3", "PTDSS1", "PTGES2", "PTGES3", "PTGR2", "PTPA", "PTPN1", "PTPN11", "PTRH2", "PTRHD1", "PUF60", "PUM3", "PUS1", "PUS7", "PWP1", "PWP2", "PYCR2", "PYGB", "PYGL", "QARS", "QDPR", "QKI", "QSOX2", "RAB13", "RAB14", "RAB1A", "RAB23", "RAB24", "RAB3GAP2", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RAB8A", "RABEPK", "RABGAP1", "RABL6", "RAC1", "RACGAP1", "RACK1", "RAD21", "RAD23A", "RAD23B", "RAD50", "RAE1", "RAI14", "RALA", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP9", "RANGAP1", "RANGRF", "RAPGEF2", "RARS", "RARS2", "RAVER1", "RB1", "RBBP4", "RBBP6", "RBBP7", "RBM10", "RBM12", "RBM12B", "RBM14", "RBM17", "RBM19", "RBM22", "RBM25", "RBM26", "RBM27", "RBM28", "RBM3", "RBM34", "RBM39", "RBM4", "RBM5", "RBM8A", "RBMX", "RCC1", "RCL1", "RCN1", "RCN2", "RCOR1", "RDH13", "RDX", "RECQL", "REEP4", "REEP5", "RELA", "REPS1", "RER1", "RETSAT", "REXO4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RHOT2", "RIF1", "RINT1", "RIOK2", "RIOX1", "RMC1", "RMDN3", "RNASEH2A", "RNF2", "RNF40", "RNH1", "RNPEP", "ROCK2", "RPA1", "RPA2", "RPAP1", "RPAP3", "RPF2", "RPL10", "RPL10A", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL32", "RPL34", "RPL35", "RPL36", "RPL36A", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPN1", "RPN2", "RPP30", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS3", "RPS3A", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPSA", "RRBP1", "RRM1", "RRM2", "RRP1", "RRP12", "RRP15", "RRP1B", "RRP8", "RRS1", "RSF1", "RSL1D1", "RSL24D1", "RSU1", "RTCB", "RTFDC1", "RTN3", "RTN4", "RTRAF", "RUFY1", "RUVBL1", "RUVBL2", "S100A10", "S100A11", "S100A13", "SACM1L", "SAE1", "SAFB", "SAFB2", "SAMHD1", "SAMM50", "SAP130", "SAP18", "SAP30BP", "SAR1A", "SARNP", "SARS", "SARS2", "SART1", "SART3", "SBDS", "SC5D", "SCAMP2", "SCAMP3", "SCARB1", "SCARB2", "SCCPDH", "SCD", "SCML2", "SCO2", "SCP2", "SCPEP1", "SCRIB", "SCRN1", "SDCBP", "SDE2", "SDF4", "SDHA", "SDHB", "SDR39U1", "SEC11A", "SEC16A", "SEC23A", "SEC23IP", "SEC24A", "SEC24B", "SEC24C", "SEC24D", "SEC31A", "SEC61A1", "SEC61B", "SEC62", "SEC63", "SENP3", "SEPHS1", "SEPT2", "SEPT7", "SEPT9", "SERBP1", "SERPINB6", "SERPINH1", "SET", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFSWAP", "SFXN1", "SFXN2", "SFXN4", "SGPL1", "SGTA", "SH3BGRL3", "SH3GL1", "SH3GLB1", "SH3PXD2B", "SHCBP1", "SHMT1", "SHMT2", "SHOC2", "SIN3A", "SKIV2L", "SKIV2L2", "SKP1", "SKP2", "SLC12A2", "SLC16A1", "SLC1A5", "SLC25A10", "SLC25A12", "SLC25A13", "SLC25A17", "SLC25A19", "SLC25A20", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A4", "SLC25A42", "SLC25A44", "SLC25A5", "SLC25A6", "SLC27A4", "SLC30A5", "SLC35B2", "SLC35F1", "SLC35F2", "SLC38A2", "SLC3A2", "SLC4A1AP", "SLC4A7", "SLC9A3R1", "SLFN11", "SLIRP", "SLK", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC6", "SMCHD1", "SMN1*", "SMNDC1", "SMPD4", "SMU1", "SMYD3", "SND1", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPC", "SNRPD2", "SNRPD3", "SNW1", "SNX1", "SNX2", "SNX27", "SNX5", "SNX6", "SNX9", "SOD2", "SON", "SORT1", "SPAG9", "SPART", "SPATA5", "SPATA5L1", "SPC25", "SPCS2", "SPEN", "SPNS1", "SPPL2A", "SPR", "SPTAN1", "SPTBN1", "SPTBN2", "SPTLC1", "SQLE", "SQSTM1", "SRCAP", "SREK1", "SRI", "SRM", "SRP14", "SRP54", "SRP68", "SRPK1", "SRPRB", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF2", "SRSF3", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSR1", "SSR4", "SSRP1", "STAG2", "STAM", "STAMBP", "STARD3", "STARD3NL", "STARD7", "STAT1", "STAT3", "STAU1", "STAU2", "STIP1", "STMN1", "STOM", "STOML2", "STRAP", "STT3B", "STUB1", "STX18", "STX4", "STX5", "STX7", "STX8", "STXBP3", "STXBP4", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGP2", "SUGT1", "SUN1", "SUPT16H", "SUPT5H", "SUPT6H", "SUPV3L1", "SURF4", "SURF6", "SUZ12", "SYAP1", "SYMPK", "SYNCRIP", "SYNE2", "SYNGR2", "TACC3", "TACO1", "TAF15", "TAF6L", "TAGLN2", "TALDO1", "TAMM41", "TARDBP", "TARS", "TARS2", "TBC1D13", "TBC1D15", "TBC1D4", "TBC1D9B", "TBCA", "TBCB", "TBL2", "TBL3", "TBRG4", "TCEA1", "TCERG1", "TCOF1", "TDP2", "TDRKH", "TECR", "TELO2", "TERF2IP", "TEX10", "TEX264", "TFAM", "TFCP2", "TFG", "TFRC", "THADA", "THOC1", "THOC2", "THOC3", "THOC6", "THOP1", "THRAP3", "THUMPD1", "THUMPD3", "THYN1", "TIAL1", "TIGAR", "TIMM13", "TIMM17A", "TIMM17B", "TIMM23", "TIMM44", "TIMM50", "TIMM8A", "TIMMDC1", "TIPRL", "TJP1", "TKT", "TLN1", "TM9SF3", "TMA7", "TMCO1", "TMED10", "TMED2", "TMEM109", "TMEM11", "TMEM126A", "TMEM192", "TMEM205", "TMEM209", "TMEM214", "TMEM230", "TMEM259", "TMEM97", "TMOD3", "TMPPE", "TMSB4X", "TMX1", "TMX2", "TMX4", "TNPO1", "TNPO3", "TOE1", "TOLLIP", "TOM1", "TOMM20", "TOMM22", "TOMM34", "TOMM40", "TOMM5", "TOMM70", "TOP1", "TOP2A", "TOP2B", "TOR1AIP1", "TOX4", "TP53", "TP53BP2", "TPD52", "TPD52L2", "TPI1", "TPM1", "TPM3", "TPM4", "TPP2", "TPR", "TPT1", "TPX2", "TRA2A", "TRA2B", "TRABD", "TRAF2", "TRAP1", "TRAPPC11", "TRAPPC3", "TRAPPC4", "TRAPPC5", "TRIM21", "TRIM25", "TRIM28", "TRIM33", "TRIO", "TRIP12", "TRIP13", "TRMT10C", "TRMT1L", "TRMT6", "TROVE2", "TRUB1", "TSFM", "TSG101", "TSN", "TSNAX", "TSPAN3", "TSPAN6", "TSR1", "TTC1", "TTC19", "TTC37", "TTC38", "TTC4", "TTK", "TTLL12", "TUBB", "TUBB2A", "TUBB2B", "TUBB4A", "TUBB4B", "TUBB6", "TUBGCP2", "TUFM", "TWF1", "TWF2", "TXLNA", "TXLNG", "TXNDC5", "TXNDC9", "TXNL1", "TXNRD1", "U2AF2", "U2SURP", "UAP1", "UBA1", "UBA2", "UBA3", "UBA6", "UBAP2L", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2O", "UBE2Q1", "UBE2S", "UBE3C", "UBE4A", "UBR2", "UBR4", "UBR5", "UBR7", "UBTF", "UBXN7", "UCHL5", "UCK2", "UFC1", "UFD1", "UFL1", "UGDH", "UGGT1", "UGP2", "UHRF1", "UMPS", "UNC45A", "UPF1", "UQCC2", "UQCRC1", "UQCRC2", "UQCRQ", "URB1", "UROD", "USMG5", "USO1", "USP10", "USP11", "USP14", "USP24", "USP28", "USP34", "USP39", "USP47", "USP48", "USP5", "USP7", "USP8", "USP9X", "UTP14A", "UTP15", "UTP18", "UTP20", "UTP4", "UTP6", "UTRN", "VAMP7", "VANGL1", "VAPA", "VAPB", "VARS1", "VBP1", "VCL", "VCP", "VDAC2", "VDAC3", "VIM", "VKORC1L1", "VMP1", "VPS26A", "VPS29", "VPS35", "VPS4A", "VPS4B", "VPS51", "VPS53", "VRK1", "WAPL", "WARS", "WBP11", "WDHD1", "WDR1", "WDR12", "WDR18", "WDR3", "WDR33", "WDR36", "WDR4", "WDR41", "WDR5", "WDR6", "WDR61", "WDR77", "WIPI2", "WIZ", "WLS", "WTAP", "XAB2", "XPNPEP1", "XPNPEP3", "XPO1", "XPO4", "XPO5", "XPOT", "XRCC5", "XRCC6", "XRN2", "YARS", "YARS2", "YBX1", "YKT6", "YLPM1", "YME1L1", "YRDC", "YTHDC1", "YTHDC2", "YTHDF2", "YWHAB", "YWHAE", "YWHAG", "YWHAQ", "ZADH2", "ZC3H11A", "ZC3H14", "ZC3H15", "ZC3H18", "ZC3H4", "ZC3HAV1", "ZCCHC11", "ZCCHC3", "ZCCHC8", "ZFR", "ZFYVE16", "ZMYM4", "ZNF280C", "ZNF318", "ZNF326", "ZNF638", "ZPR1", "ZW10", "ZYX"], "leading_proteins": ["ALDH3A2", "ALG12", "ANKLE2", "APP", "ARL6IP1", "ATP6V0A1", "ATP6V0A2", "C5orf15", "CALU", "CCDC47", "CERS2", "CHKA", "CHST14", "CLPTM1", "CLPTM1L", "COL4A3BP", "COLEC12", "COMT", "CPD", "CPVL", "CSGALNACT2", "CYB5B", "CYP51A1", "DERL1", "DHCR7", "DSC3", "DSG2", "DUSP9", "EMD", "ERLIN1", "FAM8A1", "FKBP14", "FKBP7", "FLOT1", "GLB1", "GLG1", "GOLIM4", "GPR107", "GPR108", "HLA-A", "IGF2R", "KDELR1", "KIAA0319L", "KIAA2013", "LBR", "MGST2", "NAA40", "NAMPT", "NDC1", "NUCB1", "NUCB2", "OCLN", "P3H4", "P4HA1", "PDLIM7", "PGRMC1", "PLD3", "PPT1", "PRAF2", "QSOX2", "RALA", "RCN2", "REEP4", "REEP5", "RTN3", "SC5D", "SCAMP2", "SCARB1", "SCPEP1", "SDCBP", "SEC11A", "SGPL1", "SLC16A1", "SLC30A5", "SLC35F1", "SLC35F2", "SLC4A7", "SORT1", "SPTLC1", "SSR1", "STX18", "SURF4", "SYNGR2", "TFRC", "TM9SF3", "TMEM192", "TMEM230", "TMEM97", "TSPAN3", "TSPAN6", "VMP1", "WLS", "ZADH2"]} \ No newline at end of file