diff --git a/interpro_active_site/advanced/idx2term.json b/interpro_active_site/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..9e26dfeeb6e641a33dae4961196235bdb965b21b --- /dev/null +++ b/interpro_active_site/advanced/idx2term.json @@ -0,0 +1 @@ +{} \ No newline at end of file diff --git a/interpro_active_site/basic/idx2term.json b/interpro_active_site/basic/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..9e26dfeeb6e641a33dae4961196235bdb965b21b --- /dev/null +++ b/interpro_active_site/basic/idx2term.json @@ -0,0 +1 @@ +{} \ No newline at end of file diff --git a/interpro_active_site/consensus.joblib b/interpro_active_site/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..58427094a842139f5311fb0e7a7655abd41b4626 --- /dev/null +++ b/interpro_active_site/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:9d75b0e3df24ca7693cfc68bd8a6b2c0b2e91374f1b6209d115e85ba4f0839db +size 75680 diff --git a/interpro_active_site/df_merge.tsv b/interpro_active_site/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..c57981107d970e936c6c67aa07afef8fff633223 --- /dev/null +++ b/interpro_active_site/df_merge.tsv @@ -0,0 +1 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 diff --git a/interpro_active_site/metrics.json b/interpro_active_site/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..5d23ceed4b4b80e0919b5bab2f510eac6fbb8d25 --- /dev/null +++ b/interpro_active_site/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3221, + "annotations_size": 52, + "title": "Average number of proteins per term", + "value": 2.6923076923076925 +} \ No newline at end of file diff --git a/interpro_active_site/paths.json b/interpro_active_site/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..0f78c789f6f8afd54b55c96a05e8ed9389a17cce --- /dev/null +++ b/interpro_active_site/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/interpro_active_site/fragment/C201/C201_val_log2fc"} \ No newline at end of file diff --git a/interpro_active_site/result.tsv b/interpro_active_site/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..11b96b8aafdab7eead8319348bd232336f588465 --- /dev/null +++ b/interpro_active_site/result.tsv @@ -0,0 +1,3 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Serine carboxypeptidase, serine active site [IPR018202] 0.9220012430080758 1.469407284116657 0.1417223528000428 0.9996462913310388 0.2678262828670821 3 Q9HB40,P10619 2 +Histidine acid phosphatase active site [IPR033379] 0.9260639950295098 1.4602763020177991 0.1442141523130442 0.9996959218532598 0.2678262828670821 2 P11117 1 diff --git a/interpro_active_site/selections.json b/interpro_active_site/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..978e85510885bb1a1530e34ecc4c3902027a8935 --- /dev/null +++ b/interpro_active_site/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["ATP-citrate lyase/succinyl-CoA ligase, active site [IPR017440]", "ATP:guanido phosphotransferase active site [IPR022415]", "ATPase, alpha/beta subunit, nucleotide-binding domain, active site [IPR020003]", "Adenosine/AMP deaminase active site [IPR006650]", "Adenylosuccinate synthase, active site [IPR033128]", "Beta-ketoacyl synthase, active site [IPR018201]", "Citrate synthase active site [IPR019810]", "ClpP, Ser active site [IPR018215]", "ClpP, histidine active site [IPR033135]", "Cysteine peptidase, asparagine active site [IPR025661]", "Cysteine peptidase, cysteine active site [IPR000169]", "Cysteine peptidase, histidine active site [IPR025660]", "DNA methylase, C-5 cytosine-specific, active site [IPR018117]", "DNA topoisomerase I, active site [IPR018521]", "Ferrochelatase, active site [IPR019772]", "Glucose-6-phosphate dehydrogenase, active site [IPR019796]", "Glyceraldehyde 3-phosphate dehydrogenase, active site [IPR020830]", "Glycosyl hydrolases family 31, active site [IPR030458]", "Histidine acid phosphatase active site [IPR033379]", "Hydroxymethylglutaryl-CoA lyase, active site [IPR000138]", "Hydroxymethylglutaryl-coenzyme A synthase, active site [IPR000590]", "L-lactate dehydrogenase, active site [IPR018177]", "Leu/Phe/Val dehydrogenases active site [IPR033524]", "Lipase, GDXG, putative serine active site [IPR033140]", "Malate dehydrogenase, active site [IPR001252]", "Nucleoside diphosphate kinase, active site [IPR023005]", "Orotidine 5'-phosphate decarboxylase, active site [IPR018089]", "Peptidase S16, active site [IPR008268]", "Peptidase S26A, signal peptidase I, serine active site [IPR019756]", "Peptidase S8, subtilisin, His-active site [IPR022398]", "Peptidase S8, subtilisin, Ser-active site [IPR023828]", "Peptidase S9, serine active site [IPR002471]", "Phosphoglycerate/bisphosphoglycerate mutase, active site [IPR001345]", "Phosphoribosylglycinamide formyltransferase, active site [IPR001555]", "Protein-tyrosine phosphatase, active site [IPR016130]", "Pyridine nucleotide-disulphide oxidoreductase, class I, active site [IPR012999]", "Pyruvate kinase, active site [IPR018209]", "Ribonuclease T2, His active site 1 [IPR018188]", "Ribonuclease T2, His active site 2 [IPR033130]", "Ribonucleotide reductase small subunit, acitve site [IPR030475]", "Serine carboxypeptidase, serine active site [IPR018202]", "Serine carboxypeptidases, histidine active site [IPR033124]", "Serine/threonine-protein kinase, active site [IPR008271]", "Thermonuclease active site [IPR002071]", "Thiolase, active site [IPR020610]", "Thiolase, acyl-enzyme intermediate active site [IPR020615]", "Thymidylate synthase, active site [IPR020940]", "Transaldolase, active site [IPR018225]", "Triosephosphate isomerase, active site [IPR020861]", "Tyrosine-protein kinase, active site [IPR008266]", "Ubiquitin-activating enzyme E1, Cys active site [IPR033127]", "Ubiquitin-conjugating enzyme, active site [IPR023313]"], "available_proteins": ["ACAA1", "ACAA2", "ACAT1", "ACAT2", "ACLY", "ACP2", "ACP6", "ADA", "ADSS", "AKT2", "APEH", "ATP5A1", "ATP5B", "ATP6V1A", "ATP6V1B2", "AURKA", "BLMH", "CAMK2G", "CAPN1", "CAPN2", "CDK1", "CDK12", "CDK2", "CDK4", "CDK5", "CDK6", "CDK9", "CIT", "CKB", "CKMT1A*", "CLPP", "CPVL", "CS", "CSK", "CSNK1A1", "CSNK2A1", "CSNK2A2", "CTSA", "CTSC", "DLD", "DNMT1", "DUSP3", "EIF2AK2", "EPHA7", "FASN", "FECH", "G6PD", "GAA", "GAK", "GANAB", "GAPDH", "GART", "GLUD1", "GSK3B", "GSR", "HADHB", "HMGCL", "HMGCS1", "IKBKB", "LDHA", "LDHB", "LONP1", "LYN", "MAPK1", "MDH1", "MDH2", "MTMR14", "MTMR2", "MTMR6", "NCEH1", "NEK9", "NME1", "NME2", "PAK2", "PBK", "PGAM1", "PIK3R4", "PKM", "PKMYT1", "PKN1", "PKN2", "PLK1", "PREP", "PRKAA1", "PRKAA2", "PRKACA", "PRKCB", "PRPF4B", "PTK2", "PTK7", "PTPN1", "PTPN11", "PTPN23", "PTPRF", "RIPK1", "RNASET2", "ROCK1", "ROCK2", "RPS6KA1", "RPS6KA3", "RRM2", "SCP2", "SCPEP1", "SEC11A", "SLK", "SND1", "SRC", "SRPK1", "SRPK2", "SUCLG1", "TALDO1", "TIGAR", "TLK2", "TOP1", "TPI1", "TPP2", "TRIO", "TTK", "TXNRD1", "TYMS", "UBA1", "UBA2", "UBA3", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2S", "UMPS", "VRK1"], "leading_proteins": ["ACP2", "CTSA", "SCPEP1"]} \ No newline at end of file diff --git a/interpro_binding_site/advanced/idx2term.json b/interpro_binding_site/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..9e26dfeeb6e641a33dae4961196235bdb965b21b --- /dev/null +++ b/interpro_binding_site/advanced/idx2term.json @@ -0,0 +1 @@ +{} \ No newline at end of file diff --git a/interpro_binding_site/basic/idx2term.json b/interpro_binding_site/basic/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..10e8eeba27932c124b42dde09eed12d360760c29 --- /dev/null +++ b/interpro_binding_site/basic/idx2term.json @@ -0,0 +1 @@ +{"0": "EF-Hand 1, calcium-binding site [IPR018247]", "1": "Beta tubulin, autoregulation binding site [IPR013838]"} \ No newline at end of file diff --git a/interpro_binding_site/basic/plot_0.png b/interpro_binding_site/basic/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..1b32c7281643bb30b285859aae2fe381ab8594f1 --- /dev/null +++ b/interpro_binding_site/basic/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:f5689ff57b11ff260989c27906289b500692cb6abcb2eca310df1f719f2e70a0 +size 129149 diff --git a/interpro_binding_site/basic/plot_1.png b/interpro_binding_site/basic/plot_1.png new file mode 100644 index 0000000000000000000000000000000000000000..2d51090878fa6e427eea33550bf69e8a983e00b6 --- /dev/null +++ b/interpro_binding_site/basic/plot_1.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:5b89971a9e1d821a38b83e074801ffe7a94048db9bba60e871a1be942f5866e7 +size 142891 diff --git a/interpro_binding_site/consensus.joblib b/interpro_binding_site/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..b91541e4e8ea82fb9e652ec96d47e31cf210f778 --- /dev/null +++ b/interpro_binding_site/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:7c28f364832db4e208f19bda7925cd1f7665cffeae0e963054efd144a6e86a5f +size 72990 diff --git a/interpro_binding_site/df_merge.tsv b/interpro_binding_site/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..c57981107d970e936c6c67aa07afef8fff633223 --- /dev/null +++ b/interpro_binding_site/df_merge.tsv @@ -0,0 +1 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 diff --git a/interpro_binding_site/metrics.json b/interpro_binding_site/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..0b86f5e3ef6d9f4a69795d10237db2b3acf93dab --- /dev/null +++ b/interpro_binding_site/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3221, + "annotations_size": 31, + "title": "Average number of proteins per term", + "value": 4.709677419354839 +} \ No newline at end of file diff --git a/interpro_binding_site/paths.json b/interpro_binding_site/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..110bee9a9a76c29287b11e52613cc2ef44974eaa --- /dev/null +++ b/interpro_binding_site/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/interpro_binding_site/fragment/C201/C201_val_log2fc"} \ No newline at end of file diff --git a/interpro_binding_site/result.tsv b/interpro_binding_site/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..1bf7b8c74486d5b4845bb6ca57c3602381b21d45 --- /dev/null +++ b/interpro_binding_site/result.tsv @@ -0,0 +1,5 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +EF-Hand 1, calcium-binding site [IPR018247] 0.4947993308894777 1.8685709739155687 0.0616825272031265 0.8610546839684898 0.2124620381441024 37 Q14257,Q8IXI1,P41208,Q9NWM8,O43852,Q6NUK1,Q02818,P80303,Q9Y680,Q9BPX6,Q99828,Q9BRK5,O95202 13 +Peptidase M16, zinc-binding site [IPR001431] 0.6632856469027257 1.3337981855255314 0.1822700058160014 0.9980460755632242 0.3766913453530695 5 P22695,Q10713,O43847 3 +Beta tubulin, autoregulation binding site [IPR013838] 0.5480559875583171 0.918693609223736 0.358255853478598 0.999998932864916 0.6169961921020298 6 Q13509,P07437,P04350,Q9BVA1,Q13885 5 +Aminotransferase, class-II, pyridoxal-phosphate binding site [IPR001917] 0.5756446101273577 0.2268734377649242 0.8205221571136008 1.0 0.8771098920869526 2 O15270 1 diff --git a/interpro_binding_site/selections.json b/interpro_binding_site/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..e69ab71aa616ee0446b137c4c998582063c57822 --- /dev/null +++ b/interpro_binding_site/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["2-oxo acid dehydrogenase, lipoyl-binding site [IPR003016]", "2Fe-2S ferredoxin, iron-sulphur binding site [IPR006058]", "6-phosphogluconate-binding site [IPR006184]", "AP endonuclease 1, binding site [IPR020847]", "APOBEC/CMP deaminase, zinc-binding [IPR016192]", "Aconitase family, 4Fe-4S cluster binding site [IPR018136]", "Adenylosuccinate synthase, GTP-binding site [IPR018220]", "Aminotransferase class-V, pyridoxal-phosphate binding site [IPR020578]", "Aminotransferase, class-II, pyridoxal-phosphate binding site [IPR001917]", "Aminotransferases, class-I, pyridoxal-phosphate-binding site [IPR004838]", "Beta tubulin, autoregulation binding site [IPR013838]", "Biotin-binding site [IPR001882]", "Copper centre Cu(A) [IPR001505]", "Cytochrome b5, heme-binding site [IPR018506]", "Cytochrome c oxidase, subunit Vb, zinc binding site [IPR020893]", "EF-Hand 1, calcium-binding site [IPR018247]", "Fumarate reductase/succinate dehydrogenase, FAD-binding site [IPR003952]", "Hexokinase, binding site [IPR019807]", "IQ motif, EF-hand binding site [IPR000048]", "Inositol monophosphatase, metal-binding site [IPR020583]", "Manganese/iron superoxide dismutase, binding site [IPR019833]", "PPM-type phosphatase, divalent cation binding [IPR000222]", "Peptidase M16, zinc-binding site [IPR001431]", "Peptidase M24A, methionine aminopeptidase, subfamily 2, binding site [IPR018349]", "Porphobilinogen deaminase, dipyrromethane cofactor binding site [IPR022419]", "Protein kinase, ATP binding site [IPR017441]", "RNA polymerases, subunit N, zinc binding site [IPR020789]", "Serine hydroxymethyltransferase, pyridoxal phosphate binding site [IPR019798]", "Sigma-54 interaction domain, ATP-binding site 1 [IPR025662]", "Transketolase binding site [IPR020826]", "Ureohydrolase, manganese-binding site [IPR020855]"], "available_proteins": ["ACACA", "ACO1", "ACO2", "ACTN1", "ACTN4", "ADSS", "AKT2", "APEX1", "ARG2", "AURKA", "BPNT1", "CALU", "CAMK2G", "CAPN1", "CAPN2", "CAPNS1", "CDK1", "CDK12", "CDK2", "CDK4", "CDK5", "CDK6", "CDK9", "CETN2", "CIB1", "CIT", "COX2", "COX5B", "CSK", "CSNK1A1", "CSNK2A1", "CSNK2A2", "CYB5B", "DBT", "DCTD", "DLAT", "DLST", "DST", "EHD1", "EHD4", "EIF2AK2", "EPHA7", "EPS15L1", "FKBP10", "FKBP14", "FKBP7", "GCAT", "GOT1", "GOT2", "GPD2", "GSK3B", "HK1", "HK2", "HMBS", "IDE", "ILKAP", "IQCB1", "IQGAP1", "IQGAP3", "ITSN2", "LETM1", "LYN", "MACF1", "MAPK1", "MAPK14", "MCCC1", "METAP2", "MICU1", "MYH10", "MYH14", "MYH9", "MYO18A", "MYO1B", "MYO1C", "MYO1D", "NFS1", "NRDC", "NUCB1", "NUCB2", "OXSR1", "PA2G4", "PAK2", "PC", "PCCA", "PDCD6", "PDHX", "PDP1", "PEF1", "PGD", "PKMYT1", "PKN1", "PKN2", "PLCG1", "PLK1", "PLS3", "PMPCA", "PMPCB", "POLR2L", "PPM1G", "PRKAA1", "PRKAA2", "PRKACA", "PRKCB", "PRKCSH", "PSAT1", "PTK2", "RAB18", "RCN1", "RCN2", "RHOT1", "RHOT2", "ROCK1", "ROCK2", "RPS6KA1", "RPS6KA3", "S100A11", "SDF4", "SDHA", "SDHB", "SHMT1", "SHMT2", "SLC25A12", "SLC25A24", "SLK", "SOD2", "SPTAN1", "SPTLC2", "SRC", "SRI", "SRPK1", "SRPK2", "STK26", "STK3", "STK4", "TKT", "TLK2", "TTK", "TUBB", "TUBB2A", "TUBB2B", "TUBB3", "TUBB4A", "TUBB6", "UBE3C", "UQCRC2", "VRK1"], "leading_proteins": ["CALU", "CETN2", "CIB1", "FKBP14", "FKBP7", "LETM1", "MICU1", "NRDC", "NUCB1", "NUCB2", "PMPCA", "RCN2", "RHOT2", "SDF4", "SLC25A24", "SPTLC2", "TUBB", "TUBB2A", "TUBB2B", "TUBB3", "TUBB4A", "UQCRC2"]} \ No newline at end of file diff --git a/interpro_conserved_site/advanced/idx2term.json b/interpro_conserved_site/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..57f6f9dafce477d2ab9290983cf12712a7411c24 --- /dev/null +++ b/interpro_conserved_site/advanced/idx2term.json @@ -0,0 +1 @@ +{"0": "Intermediate filament protein, conserved site [IPR018039]"} \ No newline at end of file diff --git a/interpro_conserved_site/advanced/plot_0.png b/interpro_conserved_site/advanced/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..4657dd143b8ecf5fe814b829ce5f4497129e10c7 --- /dev/null +++ b/interpro_conserved_site/advanced/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:6c6bbb4d8a1d51a5c2838412548f8ad5b68c6faeae44e098f116d1ee4a66155e +size 185481 diff --git a/interpro_conserved_site/basic/idx2term.json b/interpro_conserved_site/basic/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..137ed18f6a4c2fe4ae08566189bd0429a75020ac --- /dev/null +++ b/interpro_conserved_site/basic/idx2term.json @@ -0,0 +1 @@ +{"0": "Intermediate filament protein, conserved site [IPR018039]", "1": "Guanylate kinase, conserved site [IPR020590]", "2": "Tubulin, conserved site [IPR017975]", "3": "14-3-3 protein, conserved site [IPR023409]", "4": "Oxysterol-binding protein, conserved site [IPR018494]"} \ No newline at end of file diff --git a/interpro_conserved_site/basic/plot_0.png b/interpro_conserved_site/basic/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..bad41accaa3c93aaf1fd6a21a8b172b1897db688 --- /dev/null +++ b/interpro_conserved_site/basic/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:6acfecae510c708e6fdcd9907871500582d260629e855d3f5a5d28c7cb5e092a +size 142863 diff --git a/interpro_conserved_site/basic/plot_1.png b/interpro_conserved_site/basic/plot_1.png new file mode 100644 index 0000000000000000000000000000000000000000..d1f6c5f37e526d4584e2f68bf781fd75b0170d11 --- /dev/null +++ b/interpro_conserved_site/basic/plot_1.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:033397f3dfa505d442fc5fe4809e05c7bfb96d9c6d6363f6721376481c16922b +size 138330 diff --git a/interpro_conserved_site/basic/plot_2.png b/interpro_conserved_site/basic/plot_2.png new file mode 100644 index 0000000000000000000000000000000000000000..297536ae5660aa2083bd7ce787df96ad59c1f765 --- /dev/null +++ b/interpro_conserved_site/basic/plot_2.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:4ef9f2e3e3daf7fcdf552a36fe40b3f148c953e7e59c89933f436cc5a52cd6d3 +size 137152 diff --git a/interpro_conserved_site/basic/plot_3.png b/interpro_conserved_site/basic/plot_3.png new file mode 100644 index 0000000000000000000000000000000000000000..3f5cd0c06b8c2009b8f420d886663c175406a36e --- /dev/null +++ b/interpro_conserved_site/basic/plot_3.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:d57d11c3dc4534f31d20fb8b3438a96e691f12d848f72790bf7568ce3eb8299e +size 141593 diff --git a/interpro_conserved_site/basic/plot_4.png b/interpro_conserved_site/basic/plot_4.png new file mode 100644 index 0000000000000000000000000000000000000000..6a4e80e45f22a93419b1d9ca36e9fa60bfadbd54 --- /dev/null +++ b/interpro_conserved_site/basic/plot_4.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:1ccf18ce56aeaff78183610292d8f1b75003c66ecfeca66214a5a62b9d629581 +size 147450 diff --git a/interpro_conserved_site/consensus.joblib b/interpro_conserved_site/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..a13e74fd7e9d9be84535c86ca9dc926990b13c20 --- /dev/null +++ b/interpro_conserved_site/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:9d84357dba8a1643c590cbc06fd0f6298fcaa78e87e7b846e4d10abdb88be048 +size 92627 diff --git a/interpro_conserved_site/df_merge.tsv b/interpro_conserved_site/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..6dc006a98276278c795c71799634e68fad402811 --- /dev/null +++ b/interpro_conserved_site/df_merge.tsv @@ -0,0 +1,3 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Intermediate filament protein, conserved site [IPR018039] 6 8 2.5171640789488547 0.0118303721417152 4.060679611650485 7.546116504854369 0.7869831563787604 0.2926647109331939 1.9153715257926656 0.8924219614624045 1.3691577499316503 0.3120813432784052 5.5105284909181895e-05 1.0 0.1596960736798767 0.0688460117016781 1.2147954097366526e-05 +Syntaxin/epimorphin, conserved site [IPR006012] 3 6 2.165239635654127 0.0303693384494174 2.592233009708738 5.847087378640777 0.9961908981999794 0.2839139128702306 1.4759357288864456 1.4239341993278547 1.138258151200134 0.2914162845337057 0.0143018721877003 0.0607401038440192 0.0066572828402184 0.0379575415698398 0.0225979674873623 diff --git a/interpro_conserved_site/metrics.json b/interpro_conserved_site/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..1173e3ab334161ffd19f45c2d94a6e003d30c11f --- /dev/null +++ b/interpro_conserved_site/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3221, + "annotations_size": 280, + "title": "Average number of proteins per term", + "value": 2.7607142857142857 +} \ No newline at end of file diff --git a/interpro_conserved_site/paths.json b/interpro_conserved_site/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..7dab0e340a72bb8c49c96fdaef9ec0ea16e074ee --- /dev/null +++ b/interpro_conserved_site/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/interpro_conserved_site/fragment/C201/C201_val_log2fc"} \ No newline at end of file diff --git a/interpro_conserved_site/result.tsv b/interpro_conserved_site/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..dc174e3b88ddc655a4037fef3c91533fb25cce04 --- /dev/null +++ b/interpro_conserved_site/result.tsv @@ -0,0 +1,33 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Intermediate filament protein, conserved site [IPR018039] 0.8224028377397703 2.5171640789488547 0.0118303721417152 0.9642874888599384 0.2103803368069574 8 P02545,P20700,P07196,Q16352,P08670,P07197 6 +Syntaxin/epimorphin, conserved site [IPR006012] 0.8107263977501447 2.165239635654127 0.0303693384494174 0.9998222640540178 0.2168982469819846 6 O15400,Q9P2W9,O60499 3 +Tetraspanin, conserved site [IPR018503] 0.990990990990991 1.7260687507912102 0.0843350449000084 0.9999999999806694 0.332588909464822 2 O43657 1 +Haem oxygenase conserved site [IPR018207] 0.9872631251941596 1.7108426148126807 0.0871101703964414 0.9999999999917368 0.3341212015205972 2 P09601 1 +Guanylate kinase, conserved site [IPR020590] 0.6762052877138249 1.5398205288188536 0.1236041064805211 1.0 0.4033124995421854 6 Q9NZW5,Q00013,Q14168,Q5T2T1,Q12959 5 +Lysosome-associated membrane glycoprotein, conserved site [IPR018134] 0.9394221808014892 1.515008900411541 0.1297701501602923 1.0 0.4116023968870023 2 P13473 1 +Quinone oxidoreductase/zeta-crystallin, conserved site [IPR002364] 0.7791243117182315 1.423903626625256 0.1544743718611712 1.0 0.4552928854855572 4 Q8N4Q0,Q8WWV3 2 +3-hydroxyacyl-CoA dehydrogenase, conserved site [IPR006180] 0.9117738428083224 1.4017602370137905 0.160986856041077 1.0 0.4612670103946107 2 P40939 1 +Proteasome beta-type subunit, conserved site [IPR016050] 0.5976649398958274 1.390392949902117 0.1644095861434893 1.0 0.4639813169545746 8 P49721 1 +Heavy-metal-associated, conserved site [IPR017969] 0.9015222118670334 1.3598263227276226 0.1738848904852505 1.0 0.4820571221373283 2 P35670 1 +Sterol reductase, conserved site [IPR018083] 0.8623796210003052 1.2004005173746652 0.2299838280439421 1.0 0.5196692621245017 2 Q14739 1 +C-type lectin, conserved site [IPR018378] 0.7918608263435732 0.9192215261229748 0.3579797140198364 1.0 0.6207855475220583 2 Q5KU26 1 +Tubulin, conserved site [IPR017975] 0.5480559875583171 0.918693609223736 0.358255853478598 1.0 0.6207855475220583 6 Q13509,P07437,P04350,Q9BVA1,Q13885 5 +DnaJ domain, conserved site [IPR018253] 0.4647772517256348 0.8278611319883744 0.4077491491422624 1.0 0.6735085722339167 10 Q9Y2G8,Q96KC8 2 +Sulfatase, conserved site [IPR024607] 0.7676296986641806 0.8258028822198756 0.4089159188563065 1.0 0.6735085722339167 2 P34059 1 +Short-chain dehydrogenase/reductase, conserved site [IPR020904] 0.4479275139669226 0.7798908971457633 0.4354550969414759 1.0 0.6811588108581746 11 Q06136,Q8NBN7,Q9Y394,Q53GQ0 4 +Thioredoxin, conserved site [IPR017937] 0.4328485265869481 0.6454338382676593 0.5186460807795896 1.0 0.744523488027753 10 Q96JJ7 1 +Immunoglobulin/major histocompatibility complex, conserved site [IPR003006] 0.709537123330219 0.6129738607030192 0.5398936235617995 1.0 0.744523488027753 2 P04439 1 +Glycoside hydrolase, family 29, conserved site [IPR018526] 0.706119913016455 0.6010779118300005 0.5477880944090938 1.0 0.744523488027753 2 Q9BTY2 1 +EGF-like, conserved site [IPR013032] 0.6787822305063635 0.5090199151423467 0.6107382648496742 1.0 0.7880493739995796 2 Q04721 1 +Ubiquitin interacting motif [IPR003903] 0.4437189054726291 0.3654701114843578 0.714760513649566 1.0 0.8777760693942039 5 O75886,Q9Y6I3,Q92783,O14964 4 +Mrp, conserved site [IPR000808] 0.6169617893755746 0.3256868725671958 0.7446612773513661 1.0 0.8797685977146942 2 Q9Y5Y2 1 +14-3-3 protein, conserved site [IPR023409] 0.3996889580093333 0.2524292623061593 0.8007092842659191 1.0 0.9113764211156804 6 P62258,Q04917,P61981,P31946,P63104 5 +HMG box A DNA-binding domain, conserved site [IPR017967] 0.5500310752020018 0.2033260789640221 0.8388801731724027 1.0 0.928404934736256 3 O15347,P09429 2 +Translation elongation factor EF1B, beta/delta chains, conserved site [IPR001326] 0.5343274308791427 0.1497879742166082 0.8809318974966938 1.0 0.9450610394600546 2 P24534 1 +Mini-chromosome maintenance, conserved site [IPR018525] 0.3560457359709734 0.1015832519873267 0.9190874736499977 1.0 0.9714557520927464 6 P33991 1 +Histidine triad, conserved site [IPR019808] 0.4936315625970753 0.0952727836353461 0.924098159813006 1.0 0.9714557520927464 2 Q9BX68 1 +Oxysterol-binding protein, conserved site [IPR018494] 0.3530326594090068 0.0924349787993509 0.9263524493170116 1.0 0.9714557520927464 6 P22059,Q9BZF3,Q9BXW6,Q9BZF1,Q96SU4 5 +Dynamin, GTPase region, conserved site [IPR019762] 0.4780987884436115 0.0796917602076178 0.9364824130127848 1.0 0.9732998836108836 2 P50570 1 +DNA-directed DNA polymerase, family B, conserved site [IPR017964] 0.4666045355700401 0.0698509548886515 0.9443122900512468 1.0 0.9732998836108836 2 P28340 1 +Actin, conserved site [IPR004001] 0.4673710379117611 0.0652451351521122 0.9479788250067848 1.0 0.9732998836108836 3 P42025,P61163 2 +Macrophage migration inhibitory factor, conserved site [IPR019829] 0.4041627834731285 0.0369324636806634 0.9705388551230087 1.0 0.9846046356320378 2 P14174 1 diff --git a/interpro_conserved_site/selections.json b/interpro_conserved_site/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..e259365bfb8b5f05ffc14a98c5efc3eec974c03f --- /dev/null +++ b/interpro_conserved_site/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["14-3-3 protein, conserved site [IPR023409]", "3-hydroxyacyl-CoA dehydrogenase, conserved site [IPR006180]", "3-hydroxyisobutyrate dehydrogenase-related, conserved site [IPR002204]", "4Fe-4S ferredoxin, iron-sulphur binding, conserved site [IPR017900]", "ABC transporter-like, conserved site [IPR017871]", "AMP-binding, conserved site [IPR020845]", "AP endonuclease 1, conserved site [IPR020848]", "AT hook, DNA-binding motif [IPR017956]", "ATP synthase, F1 complex, gamma subunit conserved site [IPR023632]", "ATP-citrate lyase/succinyl-CoA ligase, conserved site [IPR033847]", "ATP-dependent RNA helicase DEAD-box, conserved site [IPR000629]", "ATPase, AAA-type, conserved site [IPR003960]", "ATPase, OSCP/delta subunit, conserved site [IPR020781]", "Acin1, RNSP1-SAP18 binding (RSB) motif [IPR032552]", "Actin, conserved site [IPR004001]", "Actin/actin-like conserved site [IPR020902]", "Actinin-type actin-binding domain, conserved site [IPR001589]", "Acyl-CoA dehydrogenase, conserved site [IPR006089]", "Acyl-CoA-binding protein, ACBP, conserved site [IPR022408]", "Adenylate kinase, conserved site [IPR033690]", "Alanine dehydrogenase/NAD(P) transhydrogenase, conserved site-1 [IPR008142]", "Alanine dehydrogenase/pyridine nucleotide transhydrogenase, conserved site-2 [IPR008143]", "Alcohol dehydrogenase, zinc-type, conserved site [IPR002328]", "Aldehyde dehydrogenase, cysteine active site [IPR016160]", "Aldehyde dehydrogenase, glutamic acid active site [IPR029510]", "Aldo/keto reductase, conserved site [IPR018170]", "Aldose 1-epimerase, conserved site [IPR018052]", "Alpha-D-phosphohexomutase, conserved site [IPR016066]", "Aminoacyl-tRNA synthetase, class I, conserved site [IPR001412]", "Amyloidogenic glycoprotein, copper-binding domain conserved site [IPR019744]", "Amyloidogenic glycoprotein, intracellular domain, conserved site [IPR019745]", "Anion exchange, conserved site [IPR018241]", "Annexin repeat, conserved site [IPR018252]", "Apoptosis regulator, Bcl-2, BH1 motif, conserved site [IPR020717]", "Apoptosis regulator, Bcl-2, BH2 motif, conserved site [IPR020726]", "Apoptosis regulator, Bcl-2, BH3 motif, conserved site [IPR020728]", "ArgE/DapE/ACY1/CPG2/YscS, conserved site [IPR001261]", "BUD31/G10-related, conserved site [IPR018230]", "Bacterial Fmu (Sun)/eukaryotic nucleolar NOL1/Nop2p, conserved site [IPR018314]", "Band 7/stomatin-like, conserved site [IPR018080]", "Bromodomain, conserved site [IPR018359]", "C-type lectin, conserved site [IPR018378]", "CAMSAP, spectrin and Ca2+/calmodulin-binding region [IPR031372]", "CAP, conserved site, C-terminal [IPR028417]", "CAP, conserved site, N-terminal [IPR018106]", "CBX family C-terminal motif [IPR033773]", "Cadherin conserved site [IPR020894]", "Calreticulin/calnexin, conserved site [IPR018124]", "Carbohydrate/purine kinase, PfkB, conserved site [IPR002173]", "Chaperonin Cpn60, conserved site [IPR018370]", "Chaperonin GroES, conserved site [IPR018369]", "Chaperonin TCP-1, conserved site [IPR002194]", "Chromo domain, conserved site [IPR023779]", "Clathrin adaptor complex, small chain [IPR000804]", "Clathrin adaptor, mu subunit, conserved site [IPR018240]", "Coproporphyrinogen III oxidase, conserved site [IPR018375]", "Cullin, conserved site [IPR016157]", "Cyclic nucleotide-binding, conserved site [IPR018488]", "Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site [IPR020892]", "Cytochrome P450, conserved site [IPR017972]", "D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site 1 [IPR029752]", "D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site [IPR029753]", "DNA ligase, ATP-dependent, conserved site [IPR016059]", "DNA methylase, C-5 cytosine-specific, conserved site [IPR031303]", "DNA methylase, N-6 adenine-specific, conserved site [IPR002052]", "DNA topoisomerase, type IIA, conserved site [IPR018522]", "DNA-directed DNA polymerase, family A, conserved site [IPR019760]", "DNA-directed DNA polymerase, family B, conserved site [IPR017964]", "DNA-directed RNA polymerase, 30-40kDa subunit, conserved site [IPR001514]", "DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site [IPR002464]", "Dihydrofolate reductase conserved site [IPR017925]", "Dihydroorotase, conserved site [IPR002195]", "DnaJ domain, conserved site [IPR018253]", "Dpy-30 motif [IPR007858]", "Dynamin, GTPase region, conserved site [IPR019762]", "Dynein light chain, type 1/2, conserved site [IPR019763]", "EGF-like calcium-binding, conserved site [IPR018097]", "EGF-like, conserved site [IPR013032]", "Electron transfer flavoprotein subunit alpha, conserved site [IPR018206]", "Electron transfer flavoprotein, beta-subunit, conserved site [IPR000049]", "Endonuclease III-like, conserved site-2 [IPR004036]", "Endonuclease III-like, iron-sulphur cluster loop motif [IPR003651]", "Enolase, conserved site [IPR020809]", "Enoyl-CoA hydratase/isomerase, conserved site [IPR018376]", "Ependymin, conserved site [IPR018224]", "Eukaryotic translation initiation factor 4E (eIF-4E), conserved site [IPR019770]", "F-actin capping protein, alpha subunit, conserved site [IPR017865]", "F-actin capping protein, beta subunit, conserved site [IPR019771]", "FERM conserved site [IPR019747]", "FLAP/GST2/LTC4S, conserved site [IPR018295]", "Fatty acid desaturase type 1, conserved site [IPR001522]", "Fibrillarin, conserved site [IPR020813]", "Fork head domain conserved site 2 [IPR030456]", "Fork head domain conserved site1 [IPR018122]", "Formate-tetrahydrofolate ligase, FTHFS, conserved site [IPR020628]", "Fructose-bisphosphate aldolase class-I active site [IPR029768]", "Fumarate lyase, conserved site [IPR020557]", "GHMP kinase, ATP-binding, conserved site [IPR006203]", "GTP1/OBG, conserved site [IPR006074]", "Galactokinase, conserved site [IPR019741]", "Gamma-glutamyl phosphate reductase GPR, conserved site [IPR020593]", "Glucosamine-6-phosphate isomerase, conserved site [IPR018321]", "Glutamate 5-kinase, conserved site [IPR019797]", "Glutamyl-tRNA(Gln) amidotransferase, subunit B, conserved site [IPR017958]", "Glutathione peroxidase conserved site [IPR029760]", "Glycoside hydrolase family 27/36, conserved site [IPR000111]", "Glycoside hydrolase, family 29, conserved site [IPR018526]", "Glycoside hydrolase, family 35, conserved site [IPR019801]", "Glycosyl hydrolases family 31, conserved site [IPR030459]", "Glyoxalase I, conserved site [IPR018146]", "Golgin subfamily A member 2, C-terminal binding motif [IPR043937]", "Guanine-nucleotide dissociation stimulator, CDC24, conserved site [IPR001331]", "Guanylate kinase, conserved site [IPR020590]", "HIND motif [IPR045347]", "HMG box A DNA-binding domain, conserved site [IPR017967]", "HMG-I/HMG-Y, DNA-binding, conserved site [IPR000637]", "Haem oxygenase conserved site [IPR018207]", "Heat shock protein 70, conserved site [IPR018181]", "Heat shock protein Hsp90, conserved site [IPR019805]", "Heavy-metal-associated, conserved site [IPR017969]", "Helix-hairpin-helix motif [IPR000445]", "Helix-hairpin-helix motif, class 2 [IPR008918]", "Histidine triad, conserved site [IPR019808]", "Histone H4, conserved site [IPR019809]", "Hydroxymethylglutaryl-CoA reductase, class I/II, conserved site [IPR023076]", "IMP dehydrogenase / GMP reductase, conserved site [IPR015875]", "Immunoglobulin/major histocompatibility complex, conserved site [IPR003006]", "Inositol monophosphatase, conserved site [IPR020550]", "Intermediate filament protein, conserved site [IPR018039]", "Isocitrate/isopropylmalate dehydrogenase, conserved site [IPR019818]", "Kinesin motor domain, conserved site [IPR019821]", "Lipocalin family conserved site [IPR022272]", "Low-density lipoprotein (LDL) receptor class A, conserved site [IPR023415]", "Lysophospholipase patatin, conserved site [IPR001423]", "Lysosome-associated membrane glycoprotein, conserved site [IPR018134]", "Macrophage migration inhibitory factor, conserved site [IPR019829]", "Malic enzyme, conserved site [IPR015884]", "Methylthiotransferase, conserved site [IPR020612]", "Mini-chromosome maintenance, conserved site [IPR018525]", "Mitogen-activated protein (MAP) kinase, conserved site [IPR003527]", "MnmG-related, conserved site [IPR020595]", "Molybdenum cofactor biosynthesis, conserved site [IPR008284]", "Mrp, conserved site [IPR000808]", "Myristoyl-CoA:protein N-myristoyltransferase, conserved site [IPR022678]", "NADH:ubiquinone oxidoreductase, 30kDa subunit, conserved site [IPR020396]", "NADH:ubiquinone oxidoreductase, 49kDa subunit, conserved site [IPR014029]", "NADH:ubiquinone oxidoreductase, 51kDa subunit, conserved site [IPR001949]", "NADH:ubiquinone oxidoreductase, 75kDa subunit, conserved site [IPR000283]", "NADH:ubiquinone oxidoreductase, subunit 1, conserved site [IPR018086]", "NUDIX hydrolase, conserved site [IPR020084]", "Oxysterol-binding protein, conserved site [IPR018494]", "P-type trefoil, conserved site [IPR017957]", "Peptidase M22, conserved site [IPR017860]", "Peptidase M24B, X-Pro dipeptidase/aminopeptidase P, conserved site [IPR001131]", "Peptidase S26A, signal peptidase I, conserved site [IPR019758]", "Peptidyl-prolyl cis-trans isomerase, PpiC-type, conserved site [IPR023058]", "Phosphatidylethanolamine-binding, conserved site [IPR001858]", "Phosphatidylinositol 3/4-kinase, conserved site [IPR018936]", "Phosphofructokinase, conserved site [IPR015912]", "Phosphoglucose isomerase, conserved site [IPR018189]", "Phosphoglycerate kinase, conserved site [IPR015911]", "Phosphomannose isomerase, type I, conserved site [IPR018050]", "Phosphoribosyl pyrophosphate synthetase, conserved site [IPR000842]", "Phosphoribosylglycinamide synthetase, conserved site [IPR020559]", "Phosphorylase pyridoxal-phosphate attachment site [IPR035090]", "Polyamine biosynthesis domain, conserved site [IPR030373]", "Polyprenyl synthetase, conserved site [IPR033749]", "Procollagen-lysine 5-dioxygenase, conserved site [IPR001006]", "Profilin conserved site [IPR027310]", "Proliferating cell nuclear antigen, PCNA, conserved site [IPR022659]", "Proteasome beta-type subunit, conserved site [IPR016050]", "Protein phosphatase 2A regulatory subunit PR55, conserved site [IPR018067]", "Proteinase inhibitor I2, Kunitz, conserved site [IPR020901]", "Proteinase inhibitor I25, cystatin, conserved site [IPR018073]", "Pseudouridine synthase TruD, conserved site [IPR020119]", "Purine phosphorylase, family 2, conserved site [IPR018099]", "Quinone oxidoreductase/zeta-crystallin, conserved site [IPR002364]", "RNA 3'-terminal phosphate cyclase-like, conserved site [IPR020719]", "RNA polymerase, beta subunit, conserved site [IPR007121]", "RNA polymerase, subunit H/Rpb5, conserved site [IPR020608]", "Ras GTPase-activating protein, conserved site [IPR023152]", "Retro-transposon transporting motif [IPR018892]", "Ribonuclease II/R, conserved site [IPR022966]", "Ribosomal RNA adenine methylase transferase, conserved site [IPR020596]", "Ribosomal S11, conserved site [IPR018102]", "Ribosomal S24e conserved site [IPR018098]", "Ribosomal protein L1, conserved site [IPR023673]", "Ribosomal protein L10e, conserved site [IPR018255]", "Ribosomal protein L11, conserved site [IPR020785]", "Ribosomal protein L13, conserved site [IPR023563]", "Ribosomal protein L13e, conserved site [IPR018256]", "Ribosomal protein L14P, conserved site [IPR019972]", "Ribosomal protein L15, conserved site [IPR001196]", "Ribosomal protein L15e, conserved site [IPR020925]", "Ribosomal protein L18e, conserved site [IPR021132]", "Ribosomal protein L19/L19e conserved site [IPR023638]", "Ribosomal protein L2, conserved site [IPR022671]", "Ribosomal protein L21e, conserved site [IPR018259]", "Ribosomal protein L22/L17, conserved site [IPR018260]", "Ribosomal protein L23/L25, conserved site [IPR001014]", "Ribosomal protein L24/L26, conserved site [IPR005825]", "Ribosomal protein L24e, conserved site [IPR023442]", "Ribosomal protein L27e, conserved site [IPR018262]", "Ribosomal protein L29, conserved site [IPR018254]", "Ribosomal protein L3, conserved site [IPR019926]", "Ribosomal protein L30, conserved site [IPR018038]", "Ribosomal protein L30e, conserved site [IPR022991]", "Ribosomal protein L31e, conserved site [IPR020052]", "Ribosomal protein L32e, conserved site [IPR018263]", "Ribosomal protein L34e, conserved site [IPR018065]", "Ribosomal protein L35Ae, conserved site [IPR018266]", "Ribosomal protein L37e, conserved site [IPR018267]", "Ribosomal protein L4/L1e, eukaryotic/archaeal, conserved site [IPR013000]", "Ribosomal protein L5, conserved site [IPR020929]", "Ribosomal protein L6, conserved site-2 [IPR002359]", "Ribosomal protein L7Ae conserved site [IPR004037]", "Ribosomal protein S10, conserved site [IPR018268]", "Ribosomal protein S13, conserved site [IPR018269]", "Ribosomal protein S14, conserved site [IPR018271]", "Ribosomal protein S17, conserved site [IPR019979]", "Ribosomal protein S17e, conserved site [IPR018273]", "Ribosomal protein S19 conserved site [IPR020934]", "Ribosomal protein S19e, conserved site [IPR018277]", "Ribosomal protein S2, conserved site [IPR018130]", "Ribosomal protein S21e, conserved site [IPR018279]", "Ribosomal protein S28e conserved site [IPR028626]", "Ribosomal protein S3, conserved site [IPR018280]", "Ribosomal protein S3Ae, conserved site [IPR018281]", "Ribosomal protein S4, conserved site [IPR018079]", "Ribosomal protein S4e, N-terminal, conserved site [IPR018199]", "Ribosomal protein S5, N-terminal, conserved site [IPR018192]", "Ribosomal protein S6e, conserved site [IPR018282]", "Ribosomal protein S7, conserved site [IPR020606]", "Ribosomal protein S8e, conserved site [IPR018283]", "Ribosomal protein S9, conserved site [IPR020574]", "Ribosome maturation protein SBDS, conserved site [IPR018023]", "RidA, conserved site [IPR019897]", "S-adenosyl-L-homocysteine hydrolase, conserved site [IPR020082]", "S-adenosylmethionine synthetase, conserved site [IPR022631]", "S100/Calbindin-D9k, conserved site [IPR001751]", "SAICAR synthetase, conserved site [IPR018236]", "SecY conserved site [IPR030659]", "Serpin, conserved site [IPR023795]", "Short-chain dehydrogenase/reductase, conserved site [IPR020904]", "Sodium/solute symporter, conserved site [IPR018212]", "Sodium:dicarboxylate symporter, conserved site [IPR018107]", "Squalene/phytoene synthase, conserved site [IPR019845]", "Stathmin, conserved site [IPR030514]", "Sterol reductase, conserved site [IPR018083]", "Succinate dehydrogenase, cytochrome b subunit, conserved site [IPR018495]", "Succinyl-CoA synthetase, beta subunit, conserved site [IPR017866]", "Sugar transporter, conserved site [IPR005829]", "Sulfatase, conserved site [IPR024607]", "Syntaxin/epimorphin, conserved site [IPR006012]", "TPP-binding enzyme, conserved site [IPR000399]", "Terpene synthase, conserved site [IPR002365]", "Tetrahydrofolate dehydrogenase/cyclohydrolase, conserved site [IPR020867]", "Tetraspanin, conserved site [IPR018503]", "Thiolase, conserved site [IPR020613]", "Thioredoxin, conserved site [IPR017937]", "Thiosulphate sulfurtransferase, conserved site [IPR001307]", "Thymidine kinase, conserved site [IPR020633]", "Thymidylate kinase, conserved site [IPR018095]", "Tr-type G domain, conserved site [IPR031157]", "Translation elongation factor EF1B, beta/delta chains, conserved site [IPR001326]", "Translation elongation factor Ts, conserved site [IPR018101]", "Translationally controlled tumour protein, conserved site [IPR018103]", "Tubulin, conserved site [IPR017975]", "Tyrosine-protein kinase, receptor class V, conserved site [IPR001426]", "UbiE/COQ5 methyltransferase, conserved site [IPR023576]", "Ubiquitin conserved site [IPR019954]", "Ubiquitin interacting motif [IPR003903]", "Ubiquitin specific protease, conserved site [IPR018200]", "Ubiquitin-activating enzyme E1, conserved site [IPR018074]", "Vinculin, conserved site [IPR000633]", "WD40 repeat, conserved site [IPR019775]", "XPG conserved site [IPR019974]", "Zinc finger, PHD-type, conserved site [IPR019786]", "Zinc finger, RING-type, conserved site [IPR017907]", "tRNA-dihydrouridine synthase, conserved site [IPR018517]"], "available_proteins": ["AAAS", "ABCB1", "ABCB10", "ABCB6", "ABCB7", "ABCB8", "ABCC4", "ABCD3", "ABCE1", "ABCF1", "ABCF2", "ABCF3", "ACAA1", "ACAA2", "ACAD9", "ACADM", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACBD5", "ACIN1", "ACLY", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACSL6", "ACTL6A", "ACTN1", "ACTN4", "ACTR1A", "ACTR1B", "ACTR2", "ACTR3", "ADH5", "ADK", "ADSL", "AFG3L2", "AHCY", "AHCYL1", "AK1", "AK2", "AK3", "AK4", "AKR1A1", "AKR1B1", "ALDH18A1", "ALDH1A2", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ANXA1", "ANXA11", "ANXA2", "ANXA4", "ANXA6", "ANXA7", "AP1M1", "AP1S1", "AP2M1", "AP2S1", "AP3M1", "APEX1", "APP", "ARIH2", "ATAD1", "ATAD2", "ATP5C1", "ATP5O", "ATP7A", "ATP7B", "BAG6", "BARD1", "BAZ1A", "BAZ1B", "BAZ2A", "BCR", "BCS1L", "BLM", "BOP1", "BPNT1", "BPTF", "BRCA1", "BRD1", "BRD2", "BRD4", "BUD31", "CAD", "CALR", "CAMSAP3", "CANX", "CAP1", "CAPZA1", "CAPZB", "CASK", "CBR1", "CBX1", "CBX2", "CBX3", "CBX5", "CBX8", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CDH2", "CDK5RAP1", "CDKAL1", "CETN2", "CHAF1B", "CHD1", "CHD1L", "CHD4", "CLGN", "CMPK1", "CNDP2", "COLEC12", "COPA", "COPZ1", "CORO1B", "CORO1C", "CORO7", "CPOX", "CRYZ", "CSTB", "CSTF1", "CTBP1", "CTBP2", "CTNNA1", "CUL1", "CUL2", "CUL3", "CUL4A", "CUL4B", "CUL5", "CYP51A1", "DCAF13", "DCAF7", "DCPS", "DCXR", "DDT", "DDX10", "DDX17", "DDX18", "DDX20", "DDX23", "DDX24", "DDX27", "DDX3X", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX51", "DDX54", "DDX6", "DHCR7", "DHFR", "DHRS7", "DHRS7B", "DHX15", "DHX16", "DHX29", "DHX30", "DHX36", "DHX38", "DHX40", "DHX57", "DHX8", "DHX9", "DIDO1", "DIMT1", "DIS3", "DLG1", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC16", "DNAJC2", "DNAJC21", "DNAJC9", "DNM1L", "DNM2", "DNMT1", "DPY30", "DRG1", "DRG2", "DSC3", "DSG2", "DST", "DTX3L", "DTYMK", "DUS2", "DYNLL1", "DYNLL2", "EARS2", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "EEF1A2", "EEF1B2", "EEF1D", "EEF2", "EIF3I", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4E", "EIF4E2", "ENO1", "ENO2", "EPB41", "EPB41L2", "EPB41L3", "EPB41L5", "EPDR1", "EPHA7", "EPN1", "EPRS", "ERCC2", "ETFA", "ETFB", "EXO1", "EZR", "FARP1", "FARP2", "FBL", "FDFT1", "FDPS", "FEN1", "FH", "FLNA", "FLNB", "FLNC", "FOXC1", "FOXK1", "FUCA1", "FUCA2", "GAA", "GALK1", "GALM", "GALNS", "GANAB", "GART", "GATB", "GCDH", "GEMIN5", "GFM1", "GLA", "GLB1", "GLO1", "GNPDA1", "GNS", "GOLGA2", "GPHN", "GPI", "GPX8", "GRHPR", "GRWD1", "GSPT1", "GTF3C2", "GUF1", "H4C1*", "HADH", "HADHA", "HADHB", "HGS", "HIBADH", "HINT2", "HLA-A", "HLA-B", "HLTF", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMGCR", "HMOX1", "HMOX2", "HSD17B10", "HSD17B12", "HSD17B4", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA13", "HSPA14", "HSPA1B", "HSPA2", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPD1", "HSPE1", "HSPH1", "HYOU1", "IARS", "IARS2", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDH3G", "ILVBL", "IMPAD1", "IMPDH1", "IMPDH2", "INA", "IQGAP1", "IQGAP3", "IVD", "KDM2A", "KDM5A", "KDSR", "KIF11", "KIF14", "KIF18A", "KIF18B", "KIF1A", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF3A", "KIF4A", "KIF5B", "LAMP1", "LAMP2", "LARS", "LARS2", "LBR", "LDLR", "LIG1", "LIG3", "LMNA", "LMNB1", "LMNB2", "LRP1", "LRWD1", "LSS", "MACF1", "MAPK1", "MAPK14", "MARS", "MAT2A", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "ME1", "ME2", "MGST2", "MIF", "MKRN2", "MPHOSPH8", "MPI", "MPP1", "MPP2", "MPP6", "MPP7", "MPST", "MRC2", "MRPL24", "MRPL3", "MRPS11", "MRPS5", "MRPS9", "MSN", "MTAP", "MTHFD1", "MTHFD1L", "MTHFD2", "MTO1", "MTOR", "ND1", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS8", "NDUFV1", "NEDD1", "NEFL", "NEFM", "NES", "NF1", "NKTR", "NLE1", "NMT1", "NNT", "NOP2", "NOTCH2", "NSD1", "NSD2", "NSD3", "NSF", "NTHL1", "NUBP2", "NUBPL", "NUDT1", "NUDT5", "NUP153", "NUP37", "NUP43", "NVL", "OSBP", "OSBPL11", "OSBPL1A", "OSBPL6", "OSBPL8", "OSBPL9", "OSGEP", "P4HB", "PAFAH1B1", "PAICS", "PAK1IP1", "PBRM1", "PCNA", "PDIA3", "PDIA4", "PDIA6", "PEBP1", "PEPD", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGK1", "PGM1", "PGM2", "PGM3", "PHF2", "PHF3", "PHGDH", "PHIP", "PI4KA", "PI4KB", "PIK3C2A", "PIN1", "PLEC", "PLOD1", "PLOD2", "PLOD3", "PLRG1", "PLS3", "PNP", "PNPLA6", "POLA1", "POLD1", "POLG", "POLR1B", "POLR1C", "POLR2B", "POLR2C", "POLR2E", "POLR3B", "PPIB", "PPIC", "PPID", "PPIE", "PPIF", "PPIG", "PPIH", "PPP2R2A", "PRKAR1A", "PRKAR2A", "PRKDC", "PRPF19", "PRPF4", "PRPS2", "PSMA4", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD4", "PUS7", "PWP1", "PWP2", "PYGB", "PYGL", "QARS", "QDPR", "RACK1", "RAD18", "RAE1", "RANBP2", "RARS", "RARS2", "RBBP4", "RBBP7", "RCL1", "RDH13", "RDX", "RIDA", "RNF2", "RNF20", "RNF40", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL15", "RPL17", "RPL18", "RPL19", "RPL21", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL37", "RPL4", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPS11", "RPS14", "RPS15", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS24", "RPS28", "RPS29", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS8", "RPS9", "RPSA", "RRP8", "RRP9", "RSF1", "RSL24D1", "RTCA", "RTN4IP1", "S100A11", "SART1", "SBDS", "SCAF11", "SCD", "SCP2", "SDHB", "SDHC", "SEC11A", "SEC61A1", "SERPINB6", "SERPINH1", "SLC1A5", "SLC27A4", "SLC4A2", "SLC5A6", "SLIT2", "SMARCA4", "SMG1", "SMS", "SMU1", "SNRNP40", "SNU13", "SORD", "SPATA5", "SPATA5L1", "SPTBN1", "SRCAP", "SRM", "STAM", "STAM2", "STMN1", "STOM", "STRN", "STX10", "STX12", "STX16", "STX18", "STX4", "STX7", "SUCLA2", "SUCLG1", "SUCLG2", "SV2A", "SYNE1", "SYNE2", "TAP1", "TAP2", "TBL1XR1", "TBL3", "TCP1", "TFB1M", "THOC6", "TK1", "TLE3", "TLN1", "TMX1", "TMX3", "TOP2A", "TOP2B", "TPT1", "TRAF2", "TRIM13", "TRIM21", "TRIM25", "TRIM27", "TRIM28", "TRIM33", "TRIM4", "TRIP13", "TRMT11", "TSFM", "TSPAN3", "TSPAN6", "TST", "TTF2", "TUBB", "TUBB2A", "TUBB2B", "TUBB3", "TUBB4A", "TUBB6", "TUFM", "TXNDC12", "TXNDC5", "TXNL1", "UBA1", "UBA2", "UBFD1", "UHRF1", "USP10", "USP11", "USP14", "USP19", "USP24", "USP28", "USP36", "USP47", "USP48", "USP5", "USP7", "USP9X", "UTP15", "UTP18", "UTRN", "VARS1", "VARS2", "VAT1", "VCL", "VCP", "VIM", "VPS4A", "VPS4B", "WARS", "WDHD1", "WDR1", "WDR11", "WDR12", "WDR18", "WDR3", "WDR36", "WDR41", "WDR5", "WDR61", "WDR7", "WDR77", "XPNPEP1", "YARS2", "YME1L1", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2"], "leading_proteins": ["ACTR1A", "ACTR1B", "ATP7B", "COLEC12", "DHRS7", "DLG1", "DNAJC1", "DNAJC16", "DNM2", "EEF1B2", "EPN1", "FUCA2", "GALNS", "HADHA", 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sha256:beedc47adf6f23574bbd35bb6a4f110123cb7078b965768456d4ac9c2a2080da +size 123856 diff --git a/interpro_domain/basic/plot_7.png b/interpro_domain/basic/plot_7.png new file mode 100644 index 0000000000000000000000000000000000000000..9a0720baa6ebdb8cc9e4fdbac406fc26f9a2a3bc --- /dev/null +++ b/interpro_domain/basic/plot_7.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:bba2d9abbffc93b6e16826f298dfae42dea0547e153f08da1d9896b1b8070df0 +size 143353 diff --git a/interpro_domain/basic/plot_8.png b/interpro_domain/basic/plot_8.png new file mode 100644 index 0000000000000000000000000000000000000000..459ecf3ee807c2f07d0b7485448131a5f692ed80 --- /dev/null +++ b/interpro_domain/basic/plot_8.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:9c0e4b8abb381e2f6adbfe7716d500fc9893b565502e40afc413ecc7c02d5f42 +size 142884 diff --git a/interpro_domain/basic/plot_9.png b/interpro_domain/basic/plot_9.png new file mode 100644 index 0000000000000000000000000000000000000000..590d7cb370eecfb3fb669e8b83d469e8d22cd77f --- /dev/null +++ b/interpro_domain/basic/plot_9.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:f09d24b0b11ddc2b3a11af039c6551ff12f46891392e685bd1424220f449555c +size 138154 diff --git a/interpro_domain/consensus.joblib b/interpro_domain/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..118199fbed7e4f31b1b28c11d696b8146eeb2768 --- /dev/null +++ b/interpro_domain/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:043f45d59f8eb3acdc27ad2810dde343ecb744295abac504922c7489f6e64607 +size 253640 diff --git a/interpro_domain/df_merge.tsv b/interpro_domain/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..cb6150d03662ae51509def706db5cffec822cf22 --- /dev/null +++ b/interpro_domain/df_merge.tsv @@ -0,0 +1,9 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +P-type ATPase, haloacid dehalogenase domain [IPR044492] 7 8 2.548795892583177 0.0108095544235906 2.941747572815534 6.145631067961165 0.9567723497044874 0.2732808833570771 1.8358630293390923 1.459204245106796 1.2102525517005158 0.2943240638910574 0.0001926635075221 1.0 0.191600110602388 0.0152248647419399 0.0004867641084232 +Intermediate filament, rod domain [IPR039008] 6 8 2.5171640789488547 0.0118303721417152 4.060679611650485 7.546116504854369 0.7869831563787604 0.2926647109331939 1.9153715257926656 0.8924219614624045 1.3691577499316503 0.3120813432784052 0.0001926635075221 1.0 0.191600110602388 0.097689242801984 5.493155547881244e-05 +EF-hand domain [IPR002048] 17 44 2.36094202451341 0.0182285800957977 12.385922330097088 43.512135922330096 1.0171858714399242 0.3947118087831401 4.608360476919044 4.087317384177653 1.201458704248258 0.3652478399429377 5.2210219426142624e-05 0.3837477700868037 0.0155897140308174 0.0001434833065057 1.2437937569102145e-06 +Cytochrome b5-like heme/steroid binding domain [IPR001199] 2 5 2.3528079751849504 0.0186322532282936 2.813106796116505 6.104368932038835 1.6405397264547834 0.1100883340733615 1.2852875686886795 0.8042848477475721 1.100790504333474 0.1612592696854457 0.0113404336176026 0.0014481500629001 0.0056684159955205 0.0025975272437437 0.018020673376298 +Band 7 domain [IPR001107] 7 8 2.272620937461822 0.0230490327969998 3.825242718446602 7.354368932038835 0.2848798017769268 0.3662852929750465 1.8717479731706237 0.7075565364256523 1.25010454777189 0.3076860385713043 0.0047446129612751 1.0 1.0 0.0186627473263165 0.0005688349419973 +Phospholipid/glycerol acyltransferase [IPR002123] 5 8 2.082068650624415 0.0373361995401293 2.4611650485436893 6.109223300970874 0.4541526786138767 0.3733328307275969 1.647577392422315 1.6678607828333205 1.200305691546449 0.3080828121567173 0.0255771152801701 1.0 1.0 0.3236592382947187 0.0062633876942655 +Cation-transporting P-type ATPase, N-terminal [IPR004014] 4 5 2.0692355367176365 0.0385239894909643 2.2985436893203883 4.150485436893204 0.5310155053290574 0.3897464493012307 1.1928988171245156 0.7984662222288074 1.1360507856968378 0.3059467081218019 0.0065740916466848 1.0 1.0 0.2167775624926856 0.0105668672564949 +Cation-transporting P-type ATPase, C-terminal [IPR006068] 4 5 2.0692355367176365 0.0385239894909643 2.2985436893203883 4.150485436893204 0.5310155053290574 0.3897464493012307 1.1928988171245156 0.7984662222288074 1.1360507856968378 0.3059467081218019 0.0065740916466848 1.0 1.0 0.2167775624926856 0.0105668672564949 diff --git a/interpro_domain/metrics.json b/interpro_domain/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..19ee077933860ea68b02e7627a5a45ed6255dae9 --- /dev/null +++ b/interpro_domain/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3221, + "annotations_size": 2651, + "title": "Average number of proteins per term", + "value": 2.210863824971709 +} \ No newline at end of file diff --git a/interpro_domain/paths.json b/interpro_domain/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..32b971711e0df7390d4706392a940d6192983751 --- /dev/null +++ b/interpro_domain/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/interpro_domain/fragment/C201/C201_val_log2fc"} \ No newline at end of file diff --git a/interpro_domain/result.tsv b/interpro_domain/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..f617d531f9b9282535af7c0c7777d52ba3ea4715 --- /dev/null +++ b/interpro_domain/result.tsv @@ -0,0 +1,207 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +P-type ATPase, haloacid dehalogenase domain [IPR044492] 0.8291316526610572 2.548795892583177 0.0108095544235906 0.999999999999693 0.248015434528147 8 P98194,Q9HD20,P20020,P05023,P16615,P35670,Q04656 7 +Intermediate filament, rod domain [IPR039008] 0.8224028377397703 2.5171640789488547 0.0118303721417152 0.99999999999998 0.248015434528147 8 P02545,P20700,P07196,Q16352,P08670,P07197 6 +EF-hand domain [IPR002048] 0.5339457747624139 2.36094202451341 0.0182285800957977 1.0 0.248015434528147 44 Q14257,Q8IXI1,P41208,Q9NWM8,O43852,Q6NUK1,Q9UJS0,Q8NF37,Q02818,O75071,P80303,Q9Y680,Q9BPX6,Q99828,Q6KCM7,Q9BRK5,O95202 17 +Cytochrome b5-like heme/steroid binding domain [IPR001199] 0.8952141059425103 2.3528079751849504 0.0186322532282936 1.0 0.248015434528147 5 O15173,O43169 2 +Band 7 domain [IPR001107] 0.7712418300653563 2.272620937461822 0.0230490327969998 1.0 0.248015434528147 8 P35232,O75477,Q99623,O94905,O75955,P27105,Q14254 7 +Phospholipid/glycerol acyltransferase [IPR002123] 0.7323867409807601 2.082068650624415 0.0373361995401293 1.0 0.2596602685584156 8 Q9HCL2,Q9NUQ2,O15228,Q92604,Q8NF37 5 +Cation-transporting P-type ATPase, N-terminal [IPR004014] 0.8283582089552218 2.0692355367176365 0.0385239894909643 1.0 0.2596602685584156 5 P05023,P20020,P98194,P16615 4 +Cation-transporting P-type ATPase, C-terminal [IPR006068] 0.8283582089552218 2.0692355367176365 0.0385239894909643 1.0 0.2596602685584156 5 P05023,P20020,P98194,P16615 4 +Target SNARE coiled-coil homology domain [IPR000727] 0.7414758323165882 1.8480551814467412 0.0645943604875105 1.0 0.3188820291478407 6 Q86Y82,O15400,O60499 3 +Intermediate filament head, DNA-binding domain [IPR006821] 0.8750388560770914 1.8171596238853636 0.0691926753417775 1.0 0.3238891129713783 4 P08670,P07197,P07196 3 +Immunoglobulin-like domain [IPR007110] 0.579661308612986 1.7969198477519446 0.0723483452121902 1.0 0.3272960122141917 14 P04439,P10321,P35613,Q08722,O75962 5 +Alcohol dehydrogenase, N-terminal [IPR013154] 0.7287812308852393 1.788772406385278 0.0736514765497176 1.0 0.328670402864497 6 Q8N4Q0,Q00796,Q8WWV3,Q08257 4 +Reticulon [IPR003388] 0.8501709667391771 1.7161252893036167 0.0861391135096363 1.0 0.3548124581840954 4 O75298,Q9NQC3,O95197 3 +CBS domain [IPR000644] 0.683671248223189 1.7007882788423387 0.0889827510413192 1.0 0.3574140500159656 7 P51790,Q6P4Q7,P51798 3 +Aminopeptidase N-like , N-terminal domain [IPR045357] 0.7085535341000001 1.6936233050770766 0.0903368866443727 1.0 0.3581032396735799 6 Q9NZ08,Q6P179,P09960,Q9UIQ6 4 +Peptidase M1, membrane alanine aminopeptidase [IPR014782] 0.7085535341000001 1.6936233050770766 0.0903368866443727 1.0 0.3581032396735799 6 Q9NZ08,Q6P179,P09960,Q9UIQ6 4 +GOLD domain [IPR009038] 0.7382218366456349 1.6731568233773146 0.0942964276339362 1.0 0.3644643935066683 5 P49755,Q9BVK6,Q15363 3 +Heat shock chaperonin-binding [IPR006636] 0.7303201439218753 1.6377449474518118 0.1014749101032217 1.0 0.3801292842043705 5 Q9BSL1,Q9NRR5,P54725 3 +Dynamin-type guanine nucleotide-binding (G) domain [IPR030381] 0.6639352189684681 1.6030460952181778 0.1089244776412512 1.0 0.3881166535308561 7 O60313,O95140,Q8IWA4,Q9H223 4 +Dynamin, N-terminal [IPR045063] 0.6639352189684681 1.6030460952181778 0.1089244776412512 1.0 0.3881166535308561 7 O60313,O95140,Q8IWA4,Q9H223 4 +Phospholipase D/Transphosphatidylase [IPR001736] 0.9484311898104988 1.5519234601792726 0.1206805387323917 1.0 0.4044308414813976 2 Q8IV08 1 +Tim10-like [IPR004217] 0.9419074246660448 1.5251926007434566 0.1272110656008729 1.0 0.4122696025769121 2 Q9Y5J9 1 +ERAP1-like C-terminal domain [IPR024571] 0.7976375505128835 1.5004651742495372 0.133493948070454 1.0 0.4258633650237949 4 Q9NZ08,Q6P179,Q9UIQ6 3 +Sterol-sensing domain [IPR000731] 0.9251320285803002 1.45645852777641 0.1452659062290009 1.0 0.4459583463583585 2 O15118 1 +Sorting nexin Vps5-like, C-terminal [IPR015404] 0.7869210447912999 1.456174443083311 0.1453444025852968 1.0 0.4459583463583585 4 Q9Y5X3,O60749 2 +Ubiquitin-associated domain [IPR015940] 0.5471320177218393 1.4399709971306025 0.1498756047297957 1.0 0.4505417396045759 12 Q9UPU5,Q9NRR5,P54725,Q04323,Q9Y5A7 5 +Peptidase M16, N-terminal [IPR011765] 0.6308954808508817 1.4376682590267889 0.1505282032368788 1.0 0.4505417396045759 7 P22695,Q5JRX3,Q10713,O43847 4 +Peptidase M16, C-terminal [IPR007863] 0.6308954808508817 1.4376682590267889 0.1505282032368788 1.0 0.4505417396045759 7 P22695,Q5JRX3,Q10713,O43847 4 +Major facilitator superfamily domain [IPR020846] 0.7792974821261899 1.4246207705272618 0.154266852677908 1.0 0.455665666754744 4 Q9H2V7,Q14728,Q7L0J3 3 +L27 domain [IPR004172] 0.6783437872012215 1.402541419542051 0.1607536309524642 1.0 0.460881377283904 5 Q14168,Q12959 2 +3-hydroxyacyl-CoA dehydrogenase, NAD binding [IPR006176] 0.9117738428083224 1.4017602370137905 0.160986856041077 1.0 0.460881377283904 2 P40939 1 +3-hydroxyacyl-CoA dehydrogenase, C-terminal [IPR006108] 0.9117738428083224 1.4017602370137905 0.160986856041077 1.0 0.460881377283904 2 P40939 1 +Heavy metal-associated domain, HMA [IPR006121] 0.9015222118670334 1.3598263227276226 0.1738848904852505 1.0 0.4727885586424608 2 P35670 1 +Heavy metal-associated domain, copper ion-binding [IPR006122] 0.9015222118670334 1.3598263227276226 0.1738848904852505 1.0 0.4727885586424608 2 P35670 1 +FAD dependent oxidoreductase [IPR006076] 0.8905905198239918 1.3482893139496046 0.1775653477632677 1.0 0.478186419128464 3 Q96CU9 1 +MD-2-related lipid-recognition domain [IPR003172] 0.8956197576887162 1.3357071107926566 0.1816450242684126 1.0 0.4785410639732989 2 P17900 1 +EXPERA domain [IPR033118] 0.895309102205651 1.3344382627329765 0.1820602672673981 1.0 0.4785410639732989 2 Q15125 1 +Prolyl 4-hydroxylase alpha subunit, Fe(2+) 2OG dioxygenase domain [IPR044862] 0.754429592788313 1.3214962865357351 0.1863359399038782 1.0 0.4847660222621993 4 O15460,P13674,Q32P28 3 +FAD-binding domain, PCMH-type [IPR016166] 0.8853681267474314 1.2938707070689297 0.1957100842318866 1.0 0.5013646057533103 2 Q15392 1 +FAD linked oxidase, N-terminal [IPR006094] 0.8853681267474314 1.2938707070689297 0.1957100842318866 1.0 0.5013646057533103 2 Q15392 1 +Mitochondrial outer membrane transport complex Sam37/metaxin, N-terminal domain [IPR019564] 0.8683993791134149 1.2627827009070092 0.2066672833107019 1.0 0.5142273822016518 3 Q13505 1 +Metaxin, glutathione S-transferase domain [IPR033468] 0.8683993791134149 1.2627827009070092 0.2066672833107019 1.0 0.5142273822016518 3 Q13505 1 +Lamin tail domain [IPR001322] 0.8666873834679857 1.256193082651741 0.2090459741108126 1.0 0.5171094326152279 3 P02545,P20700 2 +LEM domain [IPR003887] 0.6425873827676054 1.2390165004114615 0.2153393874769826 1.0 0.5271142347197424 5 P50402,P42167 2 +Syntaxin, N-terminal domain [IPR006011] 0.7330520809850616 1.2327259530246566 0.2176780256070059 1.0 0.5308780550912351 4 O15400 1 +ATPase family AAA domain-containing protein 3, N-terminal [IPR021911] 0.8648648648648607 1.210477275179035 0.2260958055873434 1.0 0.5375605207282937 2 Q9NVI7 1 +Choline/carnitine acyltransferase domain [IPR039551] 0.8642435538987245 1.207957361603152 0.2270636635974381 1.0 0.5384130341653027 2 P23786 1 +FKBP-type peptidyl-prolyl cis-trans isomerase domain [IPR001179] 0.539253027656884 1.1988893585210632 0.2305709700968863 1.0 0.5420836835230932 9 Q9NWM8,Q96AY3,Q9Y680 3 +CNNM, transmembrane domain [IPR002550] 0.8608263435849619 1.1941065437798413 0.2324362938204904 1.0 0.5436677735280578 2 Q6P4Q7 1 +Ion transporter-like, CBS domain [IPR044751] 0.8608263435849619 1.1941065437798413 0.2324362938204904 1.0 0.5436677735280578 2 Q6P4Q7 1 +Fzo/mitofusin HR2 domain [IPR006884] 0.8487107797452562 1.1451291202457363 0.2521556742428403 1.0 0.5693907090440969 2 Q8IWA4 1 +JAB1/MPN/MOV34 metalloenzyme domain [IPR000555] 0.5713351277447424 1.1354437016940593 0.2561894578014732 1.0 0.5697636347581421 7 Q92905,Q7L5N1 2 +Peptidase M3A/M3B catalytic domain [IPR001567] 0.8333129830004438 1.1281053567866146 0.2592754271235669 1.0 0.5746982920606821 3 P52888 1 +NIPSNAP [IPR012577] 0.8434296365330837 1.1238508426070888 0.2610763083007312 1.0 0.5752152743229498 2 O75323 1 +Glycosyl transferase, family 1 [IPR001296] 0.8415657036346603 1.1163521631869693 0.2642714213910959 1.0 0.5752152743229498 2 Q9BT22 1 +Glycosyl hydrolase family 38, C-terminal [IPR011682] 0.8306927617272439 1.0727379328858244 0.2833887156997887 1.0 0.5929467129598579 2 Q16706 1 +Glycoside hydrolase family 38, central domain [IPR015341] 0.8306927617272439 1.0727379328858244 0.2833887156997887 1.0 0.5929467129598579 2 Q16706 1 +Glycoside hydrolase family 38, N-terminal domain [IPR000602] 0.8306927617272439 1.0727379328858244 0.2833887156997887 1.0 0.5929467129598579 2 Q16706 1 +Prolyl 4-hydroxylase alpha-subunit, N-terminal [IPR013547] 0.8278968623796189 1.0615607872927844 0.2884351232450184 1.0 0.6001895696409292 2 O15460 1 +Plasma membrane calcium transporting P-type ATPase, C-terminal [IPR022141] 0.8275862068965523 1.0603199010819822 0.2889990884396312 1.0 0.6008157420192113 2 P20020 1 +Rpn11/EIF3F, C-terminal [IPR024969] 0.6884257348926253 1.0478214913191235 0.2947208588578069 1.0 0.6047987614509591 4 Q7L5N1 1 +NOPS [IPR012975] 0.8070229956494718 1.027995601863703 0.3039518965547354 1.0 0.6146376124405478 3 Q8WXF1,P23246 2 +TRAM/LAG1/CLN8 homology domain [IPR006634] 0.8048477315102385 1.0197564034444335 0.3078440041516335 1.0 0.6174104569922998 3 Q96CP7,Q96G23 2 +Phox homology [IPR001683] 0.4872016239451243 1.0135524810196284 0.310796341903953 1.0 0.6189432353402964 11 Q9Y5X3,Q92543,O60749,Q96L92 4 +N-acetylgalactosaminyltransferase [IPR045885] 0.6800142022909317 1.0131485575990289 0.3109892076474065 1.0 0.6189432353402964 4 Q10472 1 +Thioredoxin domain [IPR013766] 0.4056282037779204 1.0085467016517558 0.3131920794862011 1.0 0.6203005800200773 24 Q96JJ7,Q96J42,Q9Y320,Q9H3N1,Q9Y2G8,O43819 6 +L27 domain, C-terminal [IPR014775] 0.6757848927572093 0.995749323378638 0.3193719584412364 1.0 0.6244282896461131 4 Q5T2T1,Q14168,Q9NZW5 3 +Endoplasmic reticulum vesicle transporter, N-terminal [IPR039542] 0.80552966759862 0.97279714476193 0.330654132049617 1.0 0.6339038562898426 2 Q9Y282 1 +Endoplasmic reticulum vesicle transporter, C-terminal [IPR012936] 0.80552966759862 0.97279714476193 0.330654132049617 1.0 0.6339038562898426 2 Q9Y282 1 +Glycerol-3-phosphate acyltransferase-like, C-terminal domain [IPR045520] 0.8042870456663436 0.9679037425660614 0.3330924450440402 1.0 0.6339038562898426 2 Q9HCL2 1 +GPAT/DHAPAT, acyltransferase domain [IPR041728] 0.8042870456663436 0.9679037425660614 0.3330924450440402 1.0 0.6339038562898426 2 Q9HCL2 1 +Zinc finger, C3HC4 RING-type [IPR018957] 0.5783565504477717 0.9446813442757108 0.3448215841561639 1.0 0.6403456275279746 5 P38398,Q9H000 2 +C-type lectin-like [IPR001304] 0.7918608263435732 0.9192215261229748 0.3579797140198364 1.0 0.6515996153209354 2 Q5KU26 1 +CD209-like, C-type lectin-like domain [IPR033989] 0.7918608263435732 0.9192215261229748 0.3579797140198364 1.0 0.6515996153209354 2 Q5KU26 1 +Tubulin/FtsZ, 2-layer sandwich domain [IPR018316] 0.5480559875583171 0.918693609223736 0.358255853478598 1.0 0.6515996153209354 6 Q13509,P07437,P04350,Q9BVA1,Q13885 5 +Tubulin/FtsZ, GTPase domain [IPR003008] 0.5480559875583171 0.918693609223736 0.358255853478598 1.0 0.6515996153209354 6 Q13509,P07437,P04350,Q9BVA1,Q13885 5 +Tim44-like domain [IPR007379] 0.79155017086051 0.9180106454604208 0.3586132926266483 1.0 0.6515996153209354 2 O43615 1 +Immunoglobulin subtype 2 [IPR003598] 0.478692713665293 0.9081852714228504 0.3637803443768193 1.0 0.6538885127044588 10 O75962,P35613 2 +Immunoglobulin subtype [IPR003599] 0.478692713665293 0.9081852714228504 0.3637803443768193 1.0 0.6538885127044588 10 O75962,P35613 2 +Proteasome activator PA28, C-terminal domain [IPR003186] 0.7704316739641228 0.8906083351247229 0.3731393260378355 1.0 0.6598871019305981 3 P61289 1 +Proteasome activator PA28, N-terminal domain [IPR003185] 0.7704316739641228 0.8906083351247229 0.3731393260378355 1.0 0.6598871019305981 3 P61289 1 +Peptidase M16, middle/third domain [IPR032632] 0.7837837837837821 0.8878439402506116 0.3746247032838741 1.0 0.6598871019305981 2 O43847 1 +Glutathione S-transferase, N-terminal [IPR004045] 0.5219559015749976 0.8838925387183353 0.3767542253506382 1.0 0.6627574329160861 7 Q8TB36 1 +Ricin B, lectin domain [IPR000772] 0.5397131880839016 0.8783326299130867 0.379763233098001 1.0 0.6632097041783931 6 Q8N4A0,Q10472,Q9UBG0 3 +FAD/NAD(P)-binding domain [IPR023753] 0.5623339539365588 0.8718298011031023 0.3833012343568485 1.0 0.6663157851016428 5 P09622,O95831 2 +Acyltransferase, C-terminal domain [IPR032098] 0.764139216904896 0.8672902424598282 0.385783001624731 1.0 0.6675657554224295 3 Q9NUQ2,Q92604 2 +Rho GTPase-activating protein domain [IPR000198] 0.5570792209786207 0.8480462070963226 0.3964122378291934 1.0 0.6788459918305213 5 Q68EM7,Q01968 2 +SUN coiled coil domain 2 [IPR040994] 0.7716682199440744 0.8412177002558303 0.4002259862914754 1.0 0.6814380794211312 2 Q9UH99 1 +Longin domain [IPR010908] 0.7538844002485967 0.8295257368744109 0.4068069795660163 1.0 0.6867237771773027 3 O15498,O75396 2 +v-SNARE, coiled-coil homology domain [IPR042855] 0.7538844002485967 0.8295257368744109 0.4068069795660163 1.0 0.6867237771773027 3 O15498,O75396 2 +Sulfatase, N-terminal [IPR000917] 0.7676296986641806 0.8258028822198756 0.4089159188563065 1.0 0.688276889452742 2 P34059 1 +Guanylate kinase/L-type calcium channel beta subunit [IPR008145] 0.4868566036415672 0.7994719449971316 0.4240168079316775 1.0 0.6989175915110016 8 Q9NZW5,Q00013,Q14168,Q5T2T1,Q12959 5 +Guanylate kinase-like domain [IPR008144] 0.4868566036415672 0.7994719449971316 0.4240168079316775 1.0 0.6989175915110016 8 Q9NZW5,Q00013,Q14168,Q5T2T1,Q12959 5 +SLC12A transporter, C-terminal [IPR018491] 0.7604846225535835 0.7986985477140612 0.4244652290957045 1.0 0.6989175915110016 2 P55011 1 +Amino acid permease/ SLC12A domain [IPR004841] 0.7604846225535835 0.7986985477140612 0.4244652290957045 1.0 0.6989175915110016 2 P55011 1 +Glycosyltransferase 2-like [IPR001173] 0.5219053791300974 0.7926581134837661 0.4279770405509633 1.0 0.6991694599442463 6 Q10472 1 +Peptidase M41 [IPR000642] 0.7576887232059635 0.7881535767310349 0.4306068797053526 1.0 0.6991694599442463 2 Q96TA2 1 +Zinc finger, CHHC-type [IPR012996] 0.7367930391547556 0.767321739556335 0.4428902460830808 1.0 0.7080907483016169 3 P31943,P52597 2 +XPC-binding domain [IPR015360] 0.7468157812985301 0.7474934940336919 0.4547657285393538 1.0 0.7180368947932263 2 P54725 1 +RAD23A/RAD23B, UBA1 domain [IPR041811] 0.7468157812985301 0.7474934940336919 0.4547657285393538 1.0 0.7180368947932263 2 P54725 1 +Calcium uniporter protein, C-terminal [IPR006769] 0.7415346380863592 0.7279557813458356 0.4666406550305286 1.0 0.7297601226472666 2 Q8NE86 1 +Immunoglobulin C1-set [IPR003597] 0.7097576134244725 0.6711850637814171 0.5021026425207611 1.0 0.7511931964419403 3 P04439,P10321 2 +MHC class I-like antigen recognition-like [IPR011161] 0.7097576134244725 0.6711850637814171 0.5021026425207611 1.0 0.7511931964419403 3 P04439,P10321 2 +MHC class I alpha chain, alpha1 alpha2 domains [IPR001039] 0.7097576134244725 0.6711850637814171 0.5021026425207611 1.0 0.7511931964419403 3 P04439,P10321 2 +MHC class I, alpha chain, C-terminal [IPR010579] 0.7097576134244725 0.6711850637814171 0.5021026425207611 1.0 0.7511931964419403 3 P04439,P10321 2 +EB1, C-terminal [IPR004953] 0.7247592420006196 0.6669032182584577 0.5048339551430552 1.0 0.7523327564830355 2 Q15555 1 +Far upstream element-binding protein, C-terminal [IPR015096] 0.7157502329916114 0.634805218817309 0.5255554591620877 1.0 0.7634232998568189 2 Q96AE4 1 +S100/CaBP-9k-type, calcium binding, subdomain [IPR013787] 0.7145076110593311 0.6304184926535057 0.5284208148354324 1.0 0.7642643112010415 2 Q99584 1 +Zinc finger C2H2 AKAP95-type [IPR034736] 0.6920447482908711 0.6100129029319613 0.5418532603186823 1.0 0.7696190317083454 3 Q9ULX6,O43823 2 +GH15-like domain [IPR011613] 0.7076731904318043 0.6064751727640415 0.5441992638136877 1.0 0.7696190317083454 2 P46020 1 +Phosphorylase b kinase regulatory subunit alpha/beta, C-terminal domain [IPR045583] 0.7076731904318043 0.6064751727640415 0.5441992638136877 1.0 0.7696190317083454 2 P46020 1 +Ribosome receptor lysine/proline rich [IPR007794] 0.7073625349487378 0.6053943816614127 0.5449169832201299 1.0 0.7696190317083454 2 Q86UP2 1 +Alpha-L-fucosidase, C-terminal [IPR031919] 0.706119913016455 0.6010779118300005 0.5477880944090938 1.0 0.7717408864443375 2 Q9BTY2 1 +Class II aldolase/adducin N-terminal [IPR001303] 0.7036346691519045 0.5924774241606209 0.5535309339288446 1.0 0.7759970945771374 2 Q9UEY8 1 +G-protein gamma-like domain [IPR015898] 0.7027027027026913 0.5892635231708985 0.5556845102594972 1.0 0.7762639828413088 2 P63218 1 +SCP2 sterol-binding domain [IPR003033] 0.670913610938465 0.5392931259229978 0.5896846112552216 1.0 0.7901081979331862 3 P51659,Q6YN16 2 +Extended PHD (ePHD) domain [IPR034732] 0.6631448104412763 0.5139892302623904 0.607259520354313 1.0 0.8033158625046325 3 O95696,Q03164 2 +FCP1 homology domain [IPR004274] 0.6775396085740835 0.5049767148650182 0.6135751907085001 1.0 0.806554120635457 2 Q3ZCQ8 1 +ABC transporter type 1, transmembrane domain [IPR011527] 0.4140323880298475 0.5034339640003401 0.6146591974910227 1.0 0.8068654696340324 9 Q03519,Q9NRK6,P28288,Q03518,Q9NP58,Q9NUT2 6 +GINS subunit, domain A [IPR021151] 0.6597478592688477 0.5030520809050271 0.6149276560076489 1.0 0.8068654696340324 3 Q9Y248 1 +AMPK, C-terminal adenylate sensor domain [IPR032270] 0.6688412550481487 0.4770466569105189 0.6333288982507417 1.0 0.8134327193602875 2 Q13131 1 +Zinc finger, CW-type [IPR011124] 0.6626281453867617 0.457508801902261 0.6473053772185431 1.0 0.8214488056516791 2 Q9Y6X9 1 +Tripartite DENN domain [IPR037516] 0.6620068344206231 0.4555744908932052 0.6486959901139475 1.0 0.8220330161529994 2 A4D1U4 1 +Domain of unknown function DUF5600 [IPR040990] 0.6514445479962669 0.4232509759073978 0.6721121582105658 1.0 0.8371338575620944 2 Q9H223 1 +EH domain-containing protein, N-terminal [IPR031692] 0.6514445479962669 0.4232509759073978 0.6721121582105658 1.0 0.8371338575620944 2 Q9H223 1 +CARG-binding factor, N-terminal [IPR012956] 0.650823237030129 0.4213832346185809 0.6734752595402673 1.0 0.8371338575620944 2 Q99729 1 +Polyketide synthase, enoylreductase domain [IPR020843] 0.4248385754363205 0.4100835700754808 0.6817446446525257 1.0 0.8382550015890853 7 Q8N4Q0 1 +Legume-like lectin [IPR005052] 0.644299471885673 0.4020047439398999 0.6876805349763808 1.0 0.8404237465907539 2 Q12907 1 +Homeobox domain [IPR001356] 0.6241959636038446 0.3937466663971724 0.6937680839586069 1.0 0.8430955956689722 3 Q96G23 1 +Cobalamin (vitamin B12)-binding domain [IPR006158] 0.6340478409443859 0.3724369350538343 0.7095675584325123 1.0 0.854252314897634 2 P22033 1 +Peptidase M28 [IPR007484] 0.6139781503442726 0.3642615062856695 0.715662741695525 1.0 0.8571870257761748 3 Q969V3 1 +Exportin-2, central domain [IPR013713] 0.6103169670602897 0.3539265635770075 0.723393919024826 1.0 0.858777058748986 3 O15397,O95373 2 +Dynamin, GTPase domain [IPR001401] 0.6065385858916948 0.3433919551009239 0.7313036109087283 1.0 0.8607027749749999 3 O60313 1 +Peptidyl-prolyl cis-trans isomerase, PpiC-type [IPR000297] 0.62348555452003 0.3431525173266812 0.7314837238848264 1.0 0.8607027749749999 2 Q13526 1 +PSI domain [IPR016201] 0.615097856477159 0.3207861008201746 0.7483724931450368 1.0 0.8687035565307677 2 P05556 1 +EF-hand, Ca insensitive [IPR014837] 0.5770665009322681 0.2660674067362842 0.7901872961576653 1.0 0.8852480522750856 3 O43707,Q13813 2 +Protein kinase, C-terminal [IPR017892] 0.4030617496958067 0.2653660577199593 0.7907274811093479 1.0 0.8852480522750856 6 P51812 1 +14-3-3 domain [IPR023410] 0.3996889580093333 0.2524292623061593 0.8007092842659191 1.0 0.888894603261705 6 P62258,Q04917,P61981,P31946,P63104 5 +ALIX V-shaped domain [IPR025304] 0.586206896551714 0.2501245398995789 0.8024910389168356 1.0 0.8901270896102641 2 Q9H3S7 1 +BRO1 domain [IPR004328] 0.586206896551714 0.2501245398995789 0.8024910389168356 1.0 0.8901270896102641 2 Q9H3S7 1 +Fibronectin type II domain [IPR000562] 0.5685582455204513 0.2454394095201115 0.8061162176030574 1.0 0.8911651763409947 3 Q9UBV2 1 +Chromo shadow domain [IPR008251] 0.5630826600373029 0.2325872774382616 0.816081907540327 1.0 0.8988089476067331 3 P83916,P45973 2 +Chromo domain subgroup [IPR017984] 0.5630826600373029 0.2325872774382616 0.816081907540327 1.0 0.8988089476067331 3 P83916,P45973 2 +Heterogeneous nuclear ribonucleoprotein Q acidic domain [IPR041337] 0.5703634669151796 0.2157829892706031 0.8291569085562862 1.0 0.90568395738884 2 O60506 1 +IPT domain [IPR002909] 0.5638397017707288 0.2025807266232057 0.8394627555700238 1.0 0.912803841269948 2 O15031 1 +GYF domain [IPR003169] 0.5619757688723148 0.1989101718920097 0.8423330124886896 1.0 0.9141116952428218 2 Q6Y7W6 1 +Protein kinase C-like, phorbol ester/diacylglycerol-binding domain [IPR002219] 0.3693217174859908 0.1771207455247042 0.8594135469769677 1.0 0.925764044305543 7 O14578,Q8NEN9,Q13464,P05771,Q9H0H5,O75116 6 +SMARCC, C-terminal [IPR032451] 0.5483069276172594 0.1733778177057027 0.8623544599573036 1.0 0.9270485293377178 2 Q8TAQ2 1 +SMARCC, SWIRM-associated domain [IPR032448] 0.5483069276172594 0.1733778177057027 0.8623544599573036 1.0 0.9270485293377178 2 Q8TAQ2 1 +SMARCC, N-terminal [IPR032450] 0.5483069276172594 0.1733778177057027 0.8623544599573036 1.0 0.9270485293377178 2 Q8TAQ2 1 +Exosome complex component, N-terminal domain [IPR025721] 0.5365020192606336 0.153290504425598 0.8781691885478258 1.0 0.9390990394676426 2 Q9Y3B2 1 +Translation elongation factor EF1B, beta/delta subunit, guanine nucleotide exchange domain [IPR014038] 0.5343274308791427 0.1497879742166082 0.8809318974966938 1.0 0.9412940186472128 2 P24534 1 +Elongation factor 1 beta central acidic region, eukaryote [IPR018940] 0.5343274308791427 0.1497879742166082 0.8809318974966938 1.0 0.9412940186472128 2 P24534 1 +CDC48, N-terminal subdomain [IPR003338] 0.533395464429934 0.1483056432969745 0.8821015619045605 1.0 0.9414726406042616 2 P46459 1 +CDC48, domain 2 [IPR004201] 0.533395464429934 0.1483056432969745 0.8821015619045605 1.0 0.9414726406042616 2 P46459 1 +Cyclic nucleotide-binding domain [IPR000595] 0.3794242978899111 0.1456862918203211 0.8841690434452594 1.0 0.942852829514635 5 P10644,Q6P4Q7 2 +Vps16, C-terminal [IPR006925] 0.5243864554209323 0.1345535594239101 0.8929648617982959 1.0 0.9495587038216136 2 Q9H9C1 1 +FARP1/FARP2/FRMD7, FERM domain C-lobe [IPR041788] 0.5169307238272631 0.1239561512945646 0.9013499934202776 1.0 0.9554093692751524 2 O94887 1 +RBM1CTR [IPR012604] 0.5156881018949929 0.1222581203225159 0.90269459826431 1.0 0.9556882507981972 2 Q96E39 1 +Histone-binding protein RBBP4, N-terminal [IPR022052] 0.5043505282784487 0.1168231307155898 0.907000213596168 1.0 0.959097553348002 3 Q9BQ67,Q16576 2 +Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase, N-terminal [IPR018955] 0.5015537600994503 0.1123489556247297 0.9105467265033436 1.0 0.9613139673279028 3 O14874,Q15120 2 +Histidine kinase domain [IPR005467] 0.5015537600994503 0.1123489556247297 0.9105467265033436 1.0 0.9613139673279028 3 O14874,Q15120 2 +BSD domain [IPR005607] 0.5063684374029199 0.1101349393302187 0.9123023591145968 1.0 0.9620181201323772 2 Q96A49 1 +AGC-kinase, C-terminal [IPR000961] 0.3276874931373316 0.1074677634213682 0.9144178982450344 1.0 0.9632353892734616 10 O14578,P51812 2 +MCM, AAA-lid domain [IPR041562] 0.3560457359709734 0.1015832519873267 0.9190874736499977 1.0 0.9660067309424571 6 P33991 1 +MCM OB domain [IPR033762] 0.3560457359709734 0.1015832519873267 0.9190874736499977 1.0 0.9660067309424571 6 P33991 1 +MCM domain [IPR001208] 0.3560457359709734 0.1015832519873267 0.9190874736499977 1.0 0.9660067309424571 6 P33991 1 +MCM N-terminal domain [IPR027925] 0.3560457359709734 0.1015832519873267 0.9190874736499977 1.0 0.9660067309424571 6 P33991 1 +eRF1 domain 1/Pelota-like [IPR005140] 0.4951848400124106 0.0969822078547565 0.9227405239120394 1.0 0.9669913873602124 2 P62495 1 +eRF1 domain 3 [IPR005142] 0.4951848400124106 0.0969822078547565 0.9227405239120394 1.0 0.9669913873602124 2 P62495 1 +eRF1 domain 2 [IPR005141] 0.4951848400124106 0.0969822078547565 0.9227405239120394 1.0 0.9669913873602124 2 P62495 1 +E3 ligase, CCCH-type zinc finger [IPR041367] 0.4069603353819551 0.0926545303134434 0.9261780211035382 1.0 0.9694191297374172 4 Q9UPT8 1 +SWIRM domain [IPR007526] 0.4069008392912703 0.0925402352966334 0.9262688252074228 1.0 0.9694191297374172 4 Q8TAQ2,Q8NB78,Q92922 3 +Prolyl 4-hydroxylase, alpha subunit [IPR006620] 0.3445809181078814 0.0895385365311932 0.9286539288363996 1.0 0.9703017948436536 7 O15460,P13674,Q32P28 3 +Oxoglutarate/iron-dependent dioxygenase [IPR005123] 0.3445809181078814 0.0895385365311932 0.9286539288363996 1.0 0.9703017948436536 7 O15460,P13674,Q32P28 3 +Sterile alpha motif domain [IPR001660] 0.3265288966675905 0.0884963714986683 0.9294821681504156 1.0 0.970483350833695 9 Q6UWE0,Q9Y6Y8,Q15375 3 +Synaptotagmin-like mitochondrial-lipid-binding domain [IPR031468] 0.4822871348663927 0.0840951154624 0.9329808081853664 1.0 0.971964363117667 3 A0FGR8,Q8NEN9 2 +Extended synaptotagmin, C-terminal C2 domain [IPR037752] 0.4821373097235122 0.0834835022809895 0.9334670948689476 1.0 0.971964363117667 2 A0FGR8 1 +Extended synaptotagmin, C2B domain [IPR037749] 0.4821373097235122 0.0834835022809895 0.9334670948689476 1.0 0.971964363117667 2 A0FGR8 1 +Synaptotagmin, SMP domain [IPR039010] 0.4821373097235122 0.0834835022809895 0.9334670948689476 1.0 0.971964363117667 2 A0FGR8 1 +Extended synaptotagmin, C2A domain [IPR037733] 0.4821373097235122 0.0834835022809895 0.9334670948689476 1.0 0.971964363117667 2 A0FGR8 1 +Dynamin GTPase effector [IPR003130] 0.4780987884436115 0.0796917602076178 0.9364824130127848 1.0 0.972119654430974 2 P50570 1 +GTPase effector domain [IPR020850] 0.4780987884436115 0.0796917602076178 0.9364824130127848 1.0 0.972119654430974 2 P50570 1 +Dynamin stalk domain [IPR000375] 0.4780987884436115 0.0796917602076178 0.9364824130127848 1.0 0.972119654430974 2 P50570 1 +Nucleoporin, Nup133/Nup155-like, C-terminal [IPR007187] 0.4774774774774633 0.0791241532181602 0.9369338722480712 1.0 0.972119654430974 2 Q8WUM0 1 +Glutathione S-transferase, C-terminal-like [IPR010987] 0.3196977405408214 0.0742297737692801 0.9408275551542088 1.0 0.972119654430974 10 Q8TB36 1 +Ubiquitin system component CUE [IPR003892] 0.4707893101305252 0.0693367924365592 0.9447215400662629 1.0 0.9748761396324104 3 Q9Y679,Q9H1I8 2 +Exocyst complex component EXOC2/Sec5, N-terminal domain [IPR039481] 0.4594594594594434 0.0644116990041955 0.9486424149138146 1.0 0.9778439376625911 2 Q96KP1 1 +Ribosomal protein/NADH dehydrogenase domain [IPR007741] 0.4420627524075772 0.0531698605226315 0.9575965694534164 1.0 0.9830232126215676 2 P82663 1 +CELF1/2, RNA recognition motif 1 [IPR034196] 0.4389561975768659 0.0514402906786888 0.9589746799355068 1.0 0.9830232126215676 2 Q92879 1 +CELF1/2, RNA recognition motif 2 [IPR034198] 0.4389561975768659 0.0514402906786888 0.9589746799355068 1.0 0.9830232126215676 2 Q92879 1 +CELF1/2, RNA recognition motif 3 [IPR034199] 0.4389561975768659 0.0514402906786888 0.9589746799355068 1.0 0.9830232126215676 2 Q92879 1 +Damage-control phosphatase ARMT1-like, metal-binding domain [IPR002791] 0.4265299782541188 0.0452869869413204 0.963878559713713 1.0 0.9869610126693908 2 Q9NVE7 1 +Copine, C2B domain [IPR037768] 0.3748834317687346 0.0387498639358488 0.9690898175666977 1.0 0.9903843895024346 4 Q96FN4,Q86YQ8,Q99829 3 +Copine, C-terminal [IPR010734] 0.3748834317687346 0.0387498639358488 0.9690898175666977 1.0 0.9903843895024346 4 Q96FN4,Q86YQ8,Q99829 3 +Patatin-like phospholipase domain [IPR002641] 0.3858341099720382 0.0322166561870661 0.9742992733573056 1.0 0.9936236000698228 2 Q8IY17 1 +Inositol polyphosphate-related phosphatase [IPR000300] 0.3845914880397584 0.0319546129516482 0.974508246013406 1.0 0.9936236000698228 2 Q01968 1 +GUCT [IPR012562] 0.3619136377757108 0.0282165710538381 0.9774894206966112 1.0 0.993812913459695 2 Q9BQ39 1 +Domain of unknown function DUF4749 [IPR031847] 0.3557005281143122 0.0274859131935491 0.9780721752468408 1.0 0.993812913459695 2 O00151 1 +Sec23, C-terminal [IPR037550] 0.3460702081391768 0.0265512925985615 0.9788176224229588 1.0 0.993812913459695 2 Q15437 1 +Occludin homology domain [IPR010844] 0.3289841565703686 0.0253723337695753 0.979757978455196 1.0 0.9938362429253816 2 Q16625 1 +SARAH domain [IPR011524] 0.3072382727555196 0.0245023805033133 0.98045188491912 1.0 0.9938362429253816 2 Q13043 1 +Mst1 SARAH domain [IPR024205] 0.3072382727555196 0.0245023805033133 0.98045188491912 1.0 0.9938362429253816 2 Q13043 1 +Glutamine amidotransferase type 2 domain [IPR017932] 0.4073958980733491 0.0135419235618529 0.9891954384975006 1.0 1.0 3 Q06203,P08243 2 +Amine oxidase [IPR002937] 0.4067743940335743 0.0131836927128568 0.9894812398414434 1.0 1.0 3 P50336,Q8NB78 2 +Zinc finger, UBP-type [IPR001607] 0.4028403256751495 0.0109887818012384 0.991232397111983 1.0 1.0 3 Q7Z569 1 diff --git a/interpro_domain/selections.json b/interpro_domain/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..841744eb9f797351c4f7860406bfbff98a581a19 --- /dev/null +++ b/interpro_domain/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["1-acyl-sn-glycerol-3-phosphate acyltransferase [IPR004552]", "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, SH3 domain [IPR035724]", "116kDa U5 small nuclear ribonucleoprotein component, C-terminal [IPR035655]", "116kDa U5 small nuclear ribonucleoprotein component, N-terminal [IPR031950]", "14-3-3 domain [IPR023410]", "18S rRNA (guanine(1575)-N(7))-methyltransferase Bud23, C-terminal [IPR022238]", "2-oxoacid dehydrogenase acyltransferase, catalytic domain [IPR001078]", "2-oxoglutarate dehydrogenase E1 component, N-terminal domain [IPR032106]", "26S proteasome non-ATPase regulatory subunit RPN1, C-terminal [IPR041433]", "26S proteasome regulatory subunit RPN2, C-terminal [IPR040623]", "26S proteasome regulatory subunit RPN5, C-terminal domain [IPR040896]", "26S proteasome regulatory subunit Rpn6, N-terminal [IPR040773]", "26S proteasome regulatory subunit Rpn7, N-terminal [IPR045135]", "26S proteasome regulatory subunit, C-terminal [IPR013586]", "2Fe-2S ferredoxin-type iron-sulfur binding domain [IPR001041]", "3'-5' exonuclease domain [IPR002562]", "3-beta hydroxysteroid dehydrogenase/isomerase [IPR002225]", "3-hydroxyacyl-CoA dehydrogenase, C-terminal [IPR006108]", "3-hydroxyacyl-CoA dehydrogenase, NAD binding [IPR006176]", "3-hydroxyisobutyrate dehydrogenase, NAD-binding domain [IPR029154]", "3-oxo-5-alpha-steroid 4-dehydrogenase, C-terminal [IPR001104]", "4'-phosphopantetheinyl transferase domain [IPR008278]", "40S ribosomal protein S11, N-terminal [IPR032440]", "40S ribosomal protein S4, C-terminal domain [IPR032277]", "40S ribosomal protein SA, C-terminal domain [IPR032281]", "4Fe-4S ferredoxin-type, iron-sulphur binding domain [IPR017896]", "5'-AMP-activated protein kinase alpha 1 catalytic subunit, C-terminal [IPR039137]", "5'-AMP-activated protein kinase catalytic subunit alpha-2, C-terminal [IPR039148]", "6-phosphogluconate dehydrogenase, C-terminal [IPR006114]", "6-phosphogluconate dehydrogenase, NADP-binding [IPR006115]", "6-phosphogluconolactonase, DevB-type [IPR005900]", "60S ribosomal protein L10P, insertion domain [IPR040637]", "60S ribosomal protein L4, C-terminal domain [IPR025755]", "6S proteasome subunit Rpn6, C-terminal helix domain [IPR040780]", "A-kinase anchor protein 10, PKA-binding (AKB) domain [IPR037719]", "AAA ATPase, AAA+ lid domain [IPR041569]", "AAA C-terminal domain [IPR032423]", "AAA+ ATPase domain [IPR003593]", "AAR2, C-terminal [IPR033648]", "AAR2, N-terminal [IPR033647]", "AARP2CN [IPR012948]", "AATF leucine zipper-containing domain [IPR025160]", "ABC transporter type 1, transmembrane domain [IPR011527]", "ABC transporter-like, ATP-binding domain [IPR003439]", "ABC-transporter extension domain [IPR032781]", "ABC1 atypical kinase-like domain [IPR004147]", "ADAR1, first double-stranded RNA binding domain [IPR044456]", "ADAR1, third double-stranded RNA binding domain [IPR044457]", "ADCK3-like domain [IPR034646]", "ADNP, zinc finger domain [IPR045762]", "AGC-kinase, C-terminal [IPR000961]", "AIMP2, lysyl-tRNA synthetase binding domain [IPR031889]", "AIMP2, thioredoxin-like domain [IPR041503]", "ALG11 mannosyltransferase, N-terminal [IPR031814]", "ALIX V-shaped domain [IPR025304]", "AMP-binding enzyme, C-terminal domain [IPR025110]", "AMP-dependent synthetase/ligase [IPR000873]", "AMPK, C-terminal adenylate sensor domain [IPR032270]", "AP complex, mu/sigma subunit [IPR022775]", "AP-2 complex subunit mu, N-terminal [IPR043532]", "AP-3 complex subunit beta 1, serine-rich domain [IPR029394]", "AP-3 complex subunit beta, C-terminal domain [IPR029390]", "AP-3 complex subunit delta domain, metazoa [IPR010474]", "AP180 N-terminal homology (ANTH) domain [IPR011417]", "APC10/DOC domain [IPR004939]", "APPL1, BAR domain [IPR037929]", "ARHGEF1-like, PH domain [IPR041020]", "ARHGEF2, PH domain [IPR037806]", "ARID DNA-binding domain [IPR001606]", "ARIP4, DEXH-box helicase domain [IPR044573]", "ARMET, C-terminal [IPR019345]", "ARMET, N-terminal [IPR045332]", "ASCH domain [IPR007374]", "ATP synthase, F1 complex, alpha subunit nucleotide-binding domain [IPR033732]", "ATP synthase, alpha subunit, C-terminal [IPR000793]", "ATP-citrate lyase/succinyl-CoA ligase [IPR005811]", "ATP-citrate synthase, citrate-binding domain [IPR032263]", "ATP-cone domain [IPR005144]", "ATP-dependent DNA helicase RecQ, zinc-binding domain [IPR032284]", "ATP-dependent RNA helicase Ski2, C-terminal [IPR012961]", "ATP-dependent RNA helicase eIF4A, DEAD-box helicase domain [IPR044728]", "ATP-dependent helicase, C-terminal [IPR006555]", "ATP-grasp fold [IPR011761]", "ATP-grasp fold, succinyl-CoA synthetase-type [IPR013650]", "ATP-sulfurylase PUA-like domain [IPR025980]", "ATP:guanido phosphotransferase, N-terminal [IPR022413]", "ATP:guanido phosphotransferase, catalytic domain [IPR022414]", "ATPase family AAA domain-containing protein 3, N-terminal [IPR021911]", "ATPase, AAA-type, core [IPR003959]", "ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain [IPR004100]", "ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domain [IPR000194]", "ATPase, V1 complex, subunit H, C-terminal [IPR011987]", "ATPase, dynein-related, AAA domain [IPR011704]", "ATPsynthase alpha/beta subunit, N-terminal extension [IPR031686]", "AVL9/DENND6 domain [IPR018307]", "AWS domain [IPR006560]", "Abscisic acid G-protein coupled receptor-like domain [IPR025969]", "Acetyl-CoA carboxylase [IPR034733]", "Acetyl-CoA carboxylase, central domain [IPR013537]", "Acetyl-coA carboxylase zinc finger domain [IPR041010]", "Acetyl-coenzyme A carboxyltransferase, C-terminal [IPR011763]", "Acetyl-coenzyme A carboxyltransferase, N-terminal [IPR011762]", "Acid ceramidase, N-terminal [IPR029130]", "Acinus, RNA recognition motif [IPR034257]", "Aconitase A, swivel domain [IPR044137]", "Aconitase A/isopropylmalate dehydratase small subunit, swivel domain [IPR000573]", "Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain [IPR001030]", "Actin-depolymerising factor homology domain [IPR002108]", "Activating signal cointegrator 1 complex subunit 2, CUE domain [IPR041800]", "Activator of Hsp90 ATPase, N-terminal [IPR015310]", "Acyl transferase [IPR014043]", "Acyl-CoA dehydrogenase family member 10/11, N-terminal [IPR041726]", "Acyl-CoA dehydrogenase/oxidase C-terminal [IPR009075]", "Acyl-CoA dehydrogenase/oxidase, N-terminal [IPR013786]", "Acyl-CoA oxidase, C-terminal [IPR002655]", "Acyl-CoA oxidase/dehydrogenase, central domain [IPR006091]", "Acyl-CoA-binding protein, ACBP [IPR000582]", "Acyl-coenzyme A oxidase, N-terminal [IPR029320]", "Acylamino-acid-releasing enzyme, N-terminal domain [IPR045550]", "Acylglycerol kinase, C-terminal [IPR045579]", "Acyltransferase, C-terminal domain [IPR032098]", "Adaptor protein ClpS, core [IPR003769]", "Adenosine deaminase domain [IPR001365]", "Adenosine deaminase/editase [IPR002466]", "Adenylate cyclase-associated CAP, C-terminal [IPR013912]", "Adenylate cyclase-associated CAP, N-terminal [IPR013992]", "Adenylate kinase, active site lid domain [IPR007862]", "Adenylosuccinate lyase C-terminal [IPR019468]", "Afadin, cargo binding domain [IPR037977]", "Agenet-like domain [IPR008395]", "Alanine dehydrogenase/pyridine nucleotide transhydrogenase, N-terminal [IPR007886]", "Alanine dehydrogenase/pyridine nucleotide transhydrogenase, NAD(H)-binding domain [IPR007698]", "Alanyl-tRNA synthetase, class IIc, N-terminal [IPR018164]", "Alanyl-tRNA synthetase, class IIc, core domain [IPR018165]", "Alcohol dehydrogenase, N-terminal [IPR013154]", "Alcohol dehydrogenase-like, C-terminal [IPR013149]", "Aldehyde dehydrogenase domain [IPR015590]", "Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant [IPR000866]", "Alpha Spectrin, SH3 domain [IPR035825]", "Alpha galactosidase A, C-terminal beta-sandwich domain [IPR035373]", "Alpha-2-macroglobulin RAP, C-terminal [IPR010483]", "Alpha-2-macroglobulin RAP, domain 2 [IPR038001]", "Alpha-2-macroglobulin RAP, domain 3 [IPR037999]", "Alpha-2-macroglobulin receptor-associated protein, domain 1 [IPR009066]", "Alpha-D-phosphohexomutase, C-terminal [IPR005843]", "Alpha-D-phosphohexomutase, alpha/beta/alpha domain I [IPR005844]", "Alpha-D-phosphohexomutase, alpha/beta/alpha domain II [IPR005845]", "Alpha-D-phosphohexomutase, alpha/beta/alpha domain III [IPR005846]", "Alpha-L-fucosidase, C-terminal [IPR031919]", "Alpha-N-acetylglucosaminidase, C-terminal [IPR024732]", "Alpha-N-acetylglucosaminidase, N-terminal [IPR024240]", "Alpha-N-acetylglucosaminidase, tim-barrel domain [IPR024733]", "Alpha-glycerophosphate oxidase, C-terminal [IPR031656]", "Alpha-ketoglutarate-dependent dioxygenase AlkB-like [IPR027450]", "Alpha-ketoglutarate-dependent dioxygenase FTO, C-terminal [IPR024366]", "Alpha-ketoglutarate-dependent dioxygenase FTO, catalytic domain [IPR024367]", "Alpha/beta hydrolase fold-1 [IPR000073]", "Alpha/beta hydrolase fold-3 [IPR013094]", "Amidase signature domain [IPR023631]", "Amidohydrolase-related [IPR006680]", "Amidophosphoribosyltransferase, N-terminal [IPR035584]", "Amine oxidase [IPR002937]", "Amino acid permease, N-terminal [IPR013612]", "Amino acid permease/ SLC12A domain [IPR004841]", "Aminoacyl-tRNA synthetase, class I, anticodon-binding [IPR045462]", "Aminoacyl-tRNA synthetase, class II (D/K/N) [IPR004364]", "Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) [IPR002314]", "Aminoacyl-tRNA synthetase, class II [IPR006195]", "Aminoacyl-tRNA synthetase, class Ia [IPR002300]", "Aminoglycoside phosphotransferase [IPR002575]", "Aminopeptidase N-like , N-terminal domain [IPR045357]", "Aminopeptidase P [IPR033740]", "Aminopeptidase P, N-terminal [IPR007865]", "Aminotransferase class V domain [IPR000192]", "Aminotransferase, class I/classII [IPR004839]", "Amyloidogenic glycoprotein, E2 domain [IPR024329]", "Amyloidogenic glycoprotein, amyloid-beta peptide [IPR013803]", "Amyloidogenic glycoprotein, copper-binding [IPR011178]", "Amyloidogenic glycoprotein, extracellular [IPR008154]", "Amyloidogenic glycoprotein, heparin-binding [IPR015849]", "Anaphase-promoting complex subunit 1, C-terminal [IPR041221]", "Anaphase-promoting complex subunit 2, C-terminal [IPR014786]", "Anaphase-promoting complex subunit 4 long domain [IPR024790]", "Anaphase-promoting complex subunit 4, WD40 domain [IPR024977]", "Anaphase-promoting complex subunit 5 domain [IPR026000]", "Ancestral coatomer element 1, Sec16/Sec31 [IPR024298]", "Angiomotin, C-terminal [IPR024646]", "Anillin homology domain [IPR012966]", "Anillin, N-terminal domain [IPR031970]", "Anillin, PH domain [IPR037840]", "Anion-transporting ATPase-like domain [IPR025723]", "Ankyrin repeat and LEM domain-containing protein 2, LEM domain [IPR035006]", "Ankyrin repeat and SOCS box protein 6, SOCS box domain [IPR037327]", "Ankyrin, UPA domain [IPR040745]", "Ankyrin-3, death domain [IPR037971]", "Anoctamin, dimerisation domain [IPR032394]", "Anticodon-binding [IPR004154]", "Anticodon-binding domain [IPR019181]", "Antifreeze-like/N-acetylneuraminic acid synthase C-terminal [IPR006190]", "ApaG domain [IPR007474]", "Apoptosis-antagonizing transcription factor, C-terminal [IPR012617]", "Archaeal primase DnaG/twinkle, TOPRIM domain [IPR034154]", "Arf GTPase activating protein [IPR001164]", "Arfaptin homology (AH) domain [IPR010504]", "Arginyl tRNA synthetase N-terminal domain [IPR005148]", "Arginyl-tRNA synthetase, catalytic core domain [IPR035684]", "Ariadne domain [IPR045840]", "Armadillo repeat-containing domain [IPR006911]", "Aromatic amino acid beta-eliminating lyase/threonine aldolase [IPR001597]", "Asn/Gln amidotransferase [IPR018027]", "Asparagine synthase [IPR001962]", "Asparagine synthase, N-terminal domain [IPR033738]", "Aspartate/glutamate/uridylate kinase [IPR001048]", "Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding domain [IPR006131]", "Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding [IPR006132]", "Aspartic peptidase, DDI1-type [IPR019103]", "Aspartyl beta-hydroxylase/Triadin domain [IPR007943]", "Aspartyl/Glutamyl-tRNA(Gln) amidotransferase, subunit B/E, catalytic [IPR006075]", "Aspartyl/asparaginy/proline hydroxylase [IPR007803]", "Ataxin 2, SM domain [IPR025852]", "Ataxin-10 domain [IPR019156]", "Ataxin-2, C-terminal [IPR009818]", "Aurora kinase A [IPR030611]", "Aurora-A binding [IPR015128]", "Autophagy-related, C-terminal [IPR015412]", "B-block binding subunit of TFIIIC [IPR007309]", "B-box, C-terminal [IPR003649]", "B-box-type zinc finger [IPR000315]", "B3/B4 tRNA-binding domain [IPR005146]", "B30.2/SPRY domain [IPR001870]", "BAG domain [IPR003103]", "BAP29/BAP31, transmembrane domain [IPR040463]", "BAR domain [IPR004148]", "BARD1, Zinc finger, RING-type [IPR039503]", "BAT2, N-terminal [IPR009738]", "BAZ2A/BAZ2B, bromodomain [IPR037374]", "BCAS3 domain [IPR022175]", "BCS1, N-terminal [IPR014851]", "BDHCT [IPR012532]", "BEACH domain [IPR000409]", "BING4, C-terminal domain [IPR012952]", "BOP1, N-terminal domain [IPR012953]", "BP28, C-terminal domain [IPR012954]", "BR140-related, PWWD domain [IPR035502]", "BRAP2, RNA recognition motif [IPR034932]", "BRCA1, serine-rich domain [IPR025994]", "BRCA1-associated 2 [IPR011422]", "BRCT domain [IPR001357]", "BRICHOS domain [IPR007084]", "BRK domain [IPR006576]", "BRO1 domain [IPR004328]", "BRPF2, PHD domain [IPR042009]", "BRPF2, ePHD domain [IPR042004]", "BSD domain [IPR005607]", "BTB/Kelch-associated [IPR011705]", "BTB/POZ domain [IPR000210]", "BURAN domain [IPR045354]", "BZW1/2, W2 domain [IPR043510]", "Bacterial Ig-like, group 2 [IPR003343]", "Bacterial surface antigen (D15) [IPR000184]", "Band 3 cytoplasmic domain [IPR013769]", "Band 4.1 domain [IPR019749]", "Band 4.1, C-terminal [IPR008379]", "Band 7 domain [IPR001107]", "Band 7, C-terminal extension [IPR032435]", "Bap31/Bap29 cytoplasmic coiled-coil domain [IPR041672]", "Bcr-Abl oncoprotein oligomerisation [IPR015123]", "Beta-Casp domain [IPR022712]", "Beta-adaptin appendage, C-terminal subdomain [IPR015151]", "Beta-amyloid precursor protein C-terminal [IPR019543]", "Beta-catenin-like protein 1, N-terminal [IPR013180]", "Beta-galactosidase jelly roll domain [IPR025300]", "Beta-hexosaminidase, eukaryotic type, N-terminal [IPR029019]", "Beta-ketoacyl synthase, C-terminal [IPR014031]", "Beta-ketoacyl synthase, N-terminal [IPR014030]", "Beta-lactamase-related [IPR001466]", "Beta-trefoil DNA-binding domain [IPR015350]", "Bicarbonate transporter, C-terminal [IPR011531]", "Bifunctional delta 1-pyrroline-5-carboxylate synthetase, glutamate-5-kinase domain [IPR041744]", "Biliverdin reductase, catalytic [IPR015249]", "Bin3-type S-adenosyl-L-methionine binding domain [IPR024160]", "Biotin carboxylase, C-terminal [IPR005482]", "Biotin carboxylase-like, N-terminal domain [IPR005481]", "Biotin carboxylation domain [IPR011764]", "Biotin/lipoyl attachment [IPR000089]", "Bloom syndrome protein, BDHCT-box associated domain [IPR032439]", "Bloom syndrome protein, N-terminal domain [IPR032437]", "Bms1/Tsr1-type G domain [IPR030387]", "Borealin, N-terminal [IPR018851]", "Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase, N-terminal [IPR018955]", "Brdt, bromodomain, repeat I [IPR043508]", "Brdt, bromodomain, repeat II [IPR043509]", "Brix domain [IPR007109]", "Bromo adjacent homology (BAH) domain [IPR001025]", "Bromodomain [IPR001487]", "Bromodomain adjacent to zinc finger domain protein 1A, bromodomain [IPR037325]", "Bromodomain protein 4, C-terminal [IPR031354]", "Brr2, N-terminal helicase PWI domain [IPR041094]", "Butyrophylin-like, SPRY domain [IPR003879]", "C-CAP/cofactor C-like domain [IPR017901]", "C-terminal associated domain of TOPRIM [IPR031660]", "C-type lectin-like [IPR001304]", "C2 DOCK-type domain [IPR027007]", "C2 domain [IPR000008]", "C2 phosphatidylinositol 3-kinase-type domain [IPR002420]", "C2CD5, C2 domain [IPR037785]", "C4-type zinc-finger of DNA polymerase delta [IPR025687]", "CAAX prenyl protease 1, N-terminal [IPR032456]", "CAP Gly-rich domain [IPR000938]", "CAPN2, penta-EF hand, calcium binding motif [IPR042736]", "CARG-binding factor, N-terminal [IPR012956]", "CARP motif [IPR006599]", "CASK, SH3 domain [IPR035473]", "CBS domain [IPR000644]", "CCAAT-binding factor [IPR005612]", "CCD97-like, C-terminal [IPR040233]", "CCDC93, coiled-coil domain [IPR019159]", "CCR4-NOT transcription complex subunit 1, CAF1-binding domain [IPR032191]", "CCR4-NOT transcription complex subunit 1, HEAT repeat [IPR032194]", "CCR4-NOT transcription complex subunit 1, TTP binding domain [IPR032193]", "CCR4-NOT transcription complex subunit 1, domain 4 [IPR024557]", "CCR4-Not complex component, Not1, C-terminal [IPR007196]", "CD2-associated protein, first SH3 domain [IPR035775]", "CD2-associated protein, second SH3 domain [IPR035776]", "CD2-associated protein, third SH3 domain [IPR035777]", "CD209-like, C-type lectin-like domain [IPR033989]", "CD47 immunoglobulin-like [IPR013270]", "CD47 transmembrane [IPR013147]", "CD80-like, immunoglobulin C2-set [IPR013162]", "CDC48, N-terminal subdomain [IPR003338]", "CDC48, domain 2 [IPR004201]", "CDH1/2, SANT-Helical linker 1 [IPR040793]", "CELF1/2, RNA recognition motif 1 [IPR034196]", "CELF1/2, RNA recognition motif 2 [IPR034198]", "CELF1/2, RNA recognition motif 3 [IPR034199]", "CENP-T/Histone H4, histone fold [IPR035425]", "CENP-V/GFA domain [IPR006913]", "CEP170, C-terminal [IPR029300]", "CFA20 domain [IPR007714]", "CHAT domain [IPR024983]", "CHCH [IPR010625]", "CHD subfamily II, SANT-like domain [IPR009462]", "CHD, C-terminal 2 [IPR012957]", "CHD, N-terminal [IPR012958]", "CHIP, N-terminal tetratricopeptide repeat domain [IPR041312]", "CHIP/LubX , U box domain [IPR045202]", "CHORD domain [IPR007051]", "CID domain [IPR006569]", "CIDE-N domain [IPR003508]", "CKK domain [IPR014797]", "CLASP N-terminal domain [IPR024395]", "CLU central domain [IPR033646]", "CLU domain [IPR025697]", "CNNM, transmembrane domain [IPR002550]", "CNOT4, RNA recognition motif [IPR034261]", "COG complex component, COG2, C-terminal [IPR024603]", "COMM domain [IPR017920]", "COMPASS complex Set1 subunit, N-SET domain [IPR024657]", "COP9 signalosome complex subunit 4, helix turn helix domain [IPR041406]", "COQ9 [IPR013718]", "COS domain [IPR017903]", "CP2 transcription factor [IPR007604]", "CPL domain [IPR012959]", "CPSF2, metallo-hydrolase domain [IPR035639]", "CPSF7, RNA recognition motif [IPR034773]", "CRA domain [IPR013144]", "CRAL-TRIO lipid binding domain [IPR001251]", "CRIB domain [IPR000095]", "CRK, C-terminal SH3 domain [IPR035458]", "CRK, N-terminal SH3 domain [IPR035457]", "CS domain [IPR007052]", "CSK-like, SH2 domain [IPR035027]", "CSN8/PSMD8/EIF3K [IPR033464]", "CTLH, C-terminal LisH motif [IPR006595]", "CTLH/CRA C-terminal to LisH motif domain [IPR024964]", "CTP synthase GATase domain [IPR033828]", "CTP synthase, N-terminal [IPR017456]", "CUB domain [IPR000859]", "CYRIA/CYRIB, Rac1 binding domain [IPR009828]", "Cadherin prodomain [IPR014868]", "Cadherin, cytoplasmic domain [IPR000233]", "Cadherin-like [IPR002126]", "Calcineurin-like phosphoesterase domain, ApaH type [IPR004843]", "Calcineurin-like phosphoesterase domain, lpxH-type [IPR024654]", "Calcium uniporter protein, C-terminal [IPR006769]", "Calcium/calmodulin-dependent protein kinase II, association-domain [IPR013543]", "Calcyclin-binding Protein, CS domain [IPR037893]", "Calmodulin-regulated spectrin-associated protein, CH domain [IPR022613]", "Calpain subdomain III [IPR033883]", "Calponin homology domain [IPR001715]", "Caprin-1 dimerization domain [IPR041637]", "Carbamoyl-phosphate synthase large subunit, CPSase domain [IPR005483]", "Carbamoyl-phosphate synthase small subunit, GATase1 domain [IPR035686]", "Carbamoyl-phosphate synthase small subunit, N-terminal domain [IPR002474]", "Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain [IPR005479]", "Carbamoyl-phosphate synthetase, large subunit oligomerisation domain [IPR005480]", "Carbohydrate kinase PfkB [IPR011611]", "Carbon-nitrogen hydrolase [IPR003010]", "Carboxylase, conserved domain [IPR003379]", "Carboxypeptidase D, carboxypeptidase-like domain 2 [IPR034224]", "Carboxypeptidase D, carboxypeptidase-like domain 3 [IPR033848]", "Carnitine O-palmitoyltransferase, N-terminal [IPR032476]", "Casein kinase substrate, phosphoprotein PP28 [IPR019380]", "Caspase recruitment domain [IPR031964]", "Cathepsin C [IPR039412]", "Cathepsin C exclusion [IPR014882]", "Cation-transporting P-type ATPase, C-terminal [IPR006068]", "Cation-transporting P-type ATPase, N-terminal [IPR004014]", "Cationic amino acid transporter, C-terminal [IPR029485]", "Cdc23 [IPR007192]", "Cdc37, C-terminal [IPR013873]", "Cdc37, Hsp90 binding [IPR013874]", "Cdc37, N-terminal domain [IPR013855]", "Cell division control protein 73, C-terminal [IPR031336]", "Cell morphogenesis central region [IPR029473]", "Cell morphogenesis protein C-terminal [IPR025481]", "Cell morphogenesis protein N-terminal [IPR025614]", "Cellular tumor antigen p53, transactivation domain 2 [IPR040926]", "Centromere protein CENP-B, C-terminal domain [IPR015115]", "Centrosomal CEP44 domain [IPR029157]", "Chaperone DnaJ, C-terminal [IPR002939]", "Chitinase II [IPR011583]", "Choline/carnitine acyltransferase domain [IPR039551]", "Choloylglycine hydrolase/NAAA C-terminal [IPR029132]", "Chromatin assembly factor 1 subunit B, C-terminal domain [IPR029129]", "Chromatin assembly factor 1 subunit p150, C-terminal [IPR029105]", "Chromatin assembly factor 1 subunit p150, N-terminal [IPR029091]", "Chromatin target of PRMT1 protein, C-terminal [IPR025715]", "Chromo domain [IPR023780]", "Chromo domain subgroup [IPR017984]", "Chromo shadow domain [IPR008251]", "Chromo/chromo shadow domain [IPR000953]", "Chromosome segregation protein Spc25, C-terminal [IPR013255]", "Circularly permuted (CP)-type guanine nucleotide-binding (G) domain [IPR030378]", "Citron Rho-interacting kinase, catalytic domain [IPR037708]", "Citron homology (CNH) domain [IPR001180]", "Class I myosin tail homology domain [IPR010926]", "Class I myosin, motor domain [IPR036072]", "Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain [IPR041715]", "Class II PurE [IPR033626]", "Class II aldolase/adducin N-terminal [IPR001303]", "Class VI myosin, motor domain [IPR036114]", "Class XVIII myosin, motor domain [IPR036064]", "Classical protein kinase C beta, catalytic domain [IPR034664]", "Clathrin adaptor, alpha-adaptin, appendage, C-terminal subdomain [IPR003164]", "Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain [IPR008152]", "Clathrin, heavy chain, linker, core motif [IPR015348]", "Clathrin/coatomer adaptor, adaptin-like, N-terminal [IPR002553]", "Cleavage and polyadenylation specificity factor 2, C-terminal [IPR025069]", "Cleavage stimulation factor subunit 1, dimerisation domain [IPR032028]", "Cleavage stimulation factor subunit 2, hinge domain [IPR025742]", "Cleavage/polyadenylation specificity factor, A subunit, C-terminal [IPR004871]", "Cleavage/polyadenylation specificity factor, A subunit, N-terminal [IPR018846]", "Clp ATPase, C-terminal [IPR019489]", "Clustered mitochondria protein, N-terminal [IPR028275]", "Cns1/TTC4, wheel domain [IPR044059]", "CoA-binding [IPR003781]", "Coagulation factor 5/8 C-terminal domain [IPR000421]", "Coatomer beta subunit, C-terminal [IPR011710]", "Coatomer beta subunit, appendage platform domain [IPR029446]", "Coatomer subunit gamma, C-terminal [IPR032154]", "Coatomer, WD associated region [IPR006692]", "Coatomer, alpha subunit, C-terminal [IPR010714]", "Coatomer, gamma subunit, appendage, Ig-like subdomain [IPR013040]", "Cobalamin (vitamin B12)-binding domain [IPR006158]", "Cobalamin (vitamin B12)-binding module, cap domain [IPR003759]", "Cobalamin adenosyltransferase-like [IPR016030]", "Coilin, N-terminal domain [IPR031722]", "Cold shock domain [IPR011129]", "Cold-shock (CSD) domain [IPR019844]", "Cold-shock protein, DNA-binding [IPR002059]", "Complement Clr-like EGF domain [IPR026823]", "Complex 1 LYR protein domain [IPR008011]", "Condensin complex subunit 1, C-terminal [IPR032682]", "Condensin complex subunit 1, N-terminal [IPR024324]", "Conserved oligomeric Golgi complex, subunit 2, N-terminal [IPR024602]", "Conserved oligomeric Golgi complex, subunit 4 [IPR013167]", "Cop9 signalosome subunit 5 C-terminal domain [IPR040961]", "Copine, C-terminal [IPR010734]", "Copine, C2B domain [IPR037768]", "Core histone macro-H2A, macro domain [IPR035796]", "Cortactin, SH3 domain [IPR035716]", "Cortactin-binding protein-2, N-terminal [IPR019131]", "Costars domain [IPR027817]", "Creatinase, N-terminal [IPR000587]", "Cro/C1-type helix-turn-helix domain [IPR001387]", "Cullin homology domain [IPR016158]", "Cullin protein, neddylation domain [IPR019559]", "Cullin, N-terminal [IPR001373]", "Cwf19-like protein, C-terminal domain-2 [IPR006767]", "Cwf19-like, C-terminal domain-1 [IPR006768]", "Cyclic nucleotide-binding domain [IPR000595]", "Cyclin, C-terminal domain [IPR004367]", "Cyclin, N-terminal [IPR006671]", "Cyclin-like [IPR013763]", "Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain [IPR002130]", "Cystatin domain [IPR000010]", "Cysteine-rich flanking region, C-terminal [IPR000483]", "Cystine knot, C-terminal [IPR006207]", "Cytidine and deoxycytidylate deaminase domain [IPR002125]", "Cytochrome C oxidase subunit II, transmembrane domain [IPR011759]", "Cytochrome b-c1 complex subunit Rieske, transmembrane domain [IPR004192]", "Cytochrome b5-like heme/steroid binding domain [IPR001199]", "Cytochrome c oxidase assembly factor 3, mitochondrial, coiled-coil domain [IPR018628]", "Cytochrome c oxidase subunit 2, C-terminal [IPR034210]", "Cytochrome c oxidase subunit II-like C-terminal [IPR002429]", "Cytochrome c oxidase, subunit II [IPR014222]", "Cytoplasmic activation/proliferation-associated protein-1 C term [IPR022070]", "Cytoskeleton-associated protein 2, C-terminal [IPR029197]", "D-3-phosphoglycerate dehydrogenase, ASB domain [IPR045626]", "D-glucuronyl C5-epimerase, C-terminal [IPR010598]", "D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain [IPR006140]", "D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain [IPR006139]", "DALR anticodon binding [IPR008909]", "DAMP1, SANT/Myb-like domain [IPR032563]", "DAZ-associated protein 1, RNA recognition motif 1 [IPR034134]", "DAZ-associated protein 1, RNA recognition motif 2 [IPR034131]", "DBC1/CARP1 catalytically inactive NUDIX hydrolase domain [IPR025954]", "DBINO domain [IPR020838]", "DBP10, C-terminal [IPR012541]", "DDE superfamily endonuclease domain [IPR004875]", "DDHD domain [IPR004177]", "DDT domain [IPR018501]", "DDX18/Has1, DEAD-box helicase domain [IPR044773]", "DDX41, DEAD-box helicase domain [IPR044113]", "DDX47/Rrp3, DEAD-box helicase domain [IPR044765]", "DDX52/Rok1, DEAD-box helicase domain [IPR044764]", "DEAD box protein 17, ATP-binding domain [IPR046330]", "DEAD/DEAH box helicase domain [IPR011545]", "DEAD2 [IPR010614]", "DEK, C-terminal [IPR014876]", "DEUBAD domain [IPR044867]", "DExH-box ATP-dependent RNA helicase, R3H domain [IPR034083]", "DFDF domain [IPR025762]", "DHHA1 domain [IPR003156]", "DHX15, DEXH-box helicase domain [IPR044756]", "DHX57, UBA domain [IPR042615]", "DHX8/ Prp22, DEXH-box helicase domain [IPR044762]", "DHX9, DEXH-box helicase domain [IPR044447]", "DHX9, first double-stranded RNA binding domain [IPR044445]", "DHX9, second double-stranded RNA binding domain [IPR044446]", "DIRP domain [IPR033471]", "DJ-1/PfpI [IPR002818]", "DMAP1-binding domain [IPR010506]", "DML1/Misato, tubulin domain [IPR029209]", "DNA (cytosine-5)-methyltransferase 1, replication foci domain [IPR022702]", "DNA binding HTH domain, Psq-type [IPR007889]", "DNA damage inducible protein 1 ubiquitin-like domain [IPR033882]", "DNA fragmentation factor 45kDa, middle domain [IPR015121]", "DNA helicase, DnaB-like, C-terminal [IPR007694]", "DNA ligase 3, BRCT domain [IPR031916]", "DNA ligase, ATP-dependent, C-terminal [IPR012309]", "DNA ligase, ATP-dependent, N-terminal [IPR012308]", "DNA ligase, ATP-dependent, central [IPR012310]", "DNA methyltransferase 1-associated 1 [IPR008468]", "DNA mismatch repair protein MutS, C-terminal [IPR000432]", "DNA mismatch repair protein MutS, clamp [IPR007861]", "DNA mismatch repair protein MutS, connector domain [IPR007860]", "DNA mismatch repair protein MutS, core [IPR007696]", "DNA mismatch repair protein MutS-like, N-terminal [IPR007695]", "DNA mitochondrial polymerase, exonuclease domain [IPR041336]", "DNA polymerase alpha catalytic subunit, N-terminal domain [IPR024647]", "DNA polymerase alpha catalytic subunit, catalytic domain [IPR045846]", "DNA polymerase alpha, subunit B, N-terminal [IPR013627]", "DNA polymerase alpha/delta/epsilon, subunit B [IPR007185]", "DNA polymerase delta subunit 2, C-terminal domain [IPR041863]", "DNA polymerase delta subunit, OB-fold domain [IPR040663]", "DNA polymerase epsilon subunit B, N-terminal [IPR024639]", "DNA polymerase epsilon, catalytic subunit A, C-terminal [IPR013697]", "DNA recombination and repair protein RecA, monomer-monomer interface [IPR020587]", "DNA repair Nbs1, C-terminal [IPR013908]", "DNA replication complex GINS protein SLD5, C-terminal [IPR031633]", "DNA replication factor Dna2, N-terminal [IPR014808]", "DNA replication factor RFC1, C-terminal [IPR013725]", "DNA topoisomerase 2, TOPRIM domain [IPR034157]", "DNA topoisomerase I, DNA binding, eukaryotic-type [IPR008336]", "DNA topoisomerase I, catalytic core, eukaryotic-type [IPR013500]", "DNA topoisomerase I, eukaryotic-type [IPR013499]", "DNA topoisomerase, type IIA, domain A [IPR002205]", "DNA topoisomerase, type IIA, subunit B, domain 2 [IPR013506]", "DNA-binding RFX-type winged-helix domain [IPR003150]", "DNA-dependent protein kinase catalytic subunit, CC3 [IPR012582]", "DNA-dependent protein kinase catalytic subunit, CC5 [IPR045581]", "DNA-dependent protein kinase catalytic subunit, catalytic domain [IPR037706]", "DNA-directed DNA polymerase, family A, palm domain [IPR001098]", "DNA-directed DNA polymerase, family B, exonuclease domain [IPR006133]", "DNA-directed DNA polymerase, family B, multifunctional domain [IPR006134]", "DNA-directed RNA polymerase I subunit RPA2, domain 4 [IPR009674]", "DNA-directed RNA polymerase III subunit RPC1, C-terminal [IPR035698]", "DNA-directed RNA polymerase III subunit RPC1, N-terminal [IPR035697]", "DNA-directed RNA polymerase, N-terminal [IPR029262]", "DNA-directed RNA polymerase, RpoA/D/Rpb3-type [IPR011263]", "DNA-directed RNA polymerase, insert domain [IPR011262]", "DNA-directed RNA polymerase, subunit 2, hybrid-binding domain [IPR007120]", "DNA-repair protein Xrcc1, N-terminal [IPR002706]", "DNA/RNA non-specific endonuclease [IPR001604]", "DNA/RNA-binding domain, Est1-type [IPR018834]", "DNA/RNA-binding protein Kin17, WH-like domain [IPR019447]", "DNA2/NAM7 helicase, helicase domain [IPR041677]", "DNA2/NAM7 helicase-like, C-terminal [IPR041679]", "DOCKER domain [IPR027357]", "DPF1-3, N-terminal domain [IPR025750]", "DSBA-like thioredoxin domain [IPR001853]", "DTHCT [IPR012542]", "DTX3L, RING-HC finger [IPR042843]", "DUS-like, FMN-binding domain [IPR035587]", "DUS2, double-stranded RNA binding domain [IPR044463]", "DWNN domain [IPR014891]", "DZF domain [IPR006561]", "Damage-control phosphatase ARMT1-like, metal-binding domain [IPR002791]", "Dbl homology (DH) domain [IPR000219]", "Death domain [IPR000488]", "Dedicator of cytokinesis C, C2 domain [IPR037808]", "Dedicator of cytokinesis C/D, N-terminal [IPR021816]", "Dehydrogenase, E1 component [IPR001017]", "Deltex, C-terminal [IPR039396]", "Deoxycytidylate deaminase domain [IPR035105]", "Deoxynucleoside kinase domain [IPR031314]", "Desmoplakin, SH3 domain [IPR041615]", "Desmoplakin, spectrin-like domain [IPR041573]", "Deubiquitinating enzyme MINDY-3/4, conserved domain [IPR025257]", "Diacylglycerol kinase, catalytic domain [IPR001206]", "Diacylglycerol/phorbol-ester binding [IPR020454]", "Diaphanous autoregulatory (DAD) domain [IPR014767]", "Dicer dimerisation domain [IPR005034]", "Dicer, double-stranded RNA-binding domain [IPR044441]", "Dihydrofolate reductase domain [IPR001796]", "Dilute domain [IPR002710]", "Dipeptidyl peptidase 8 /9 ,N-terminal [IPR045785]", "Dipeptidylpeptidase IV, N-terminal domain [IPR002469]", "Dis3-like cold-shock domain 2 [IPR041505]", "Disks large homologue 1, N-terminal PEST domain [IPR019590]", "Disulphide isomerase [IPR005788]", "DnaJ domain [IPR001623]", "DnaJ homolog subfamily C member 16, TRX domain [IPR043361]", "DnaJ homologue subfamily C, GRV2/DNAJC13, N-terminal domain [IPR045802]", "DnaJ-like protein C11, C-terminal [IPR024586]", "Dolichyl-phosphate beta-glucosyltransferase [IPR035518]", "Dolichyldiphosphatase, PAP2 domain [IPR039667]", "Domain of unknown function DM14 [IPR006608]", "Domain of unknown function DUF1087 [IPR009463]", "Domain of unknown function DUF1115 [IPR010541]", "Domain of unknown function DUF1605 [IPR011709]", "Domain of unknown function DUF1731 [IPR013549]", "Domain of unknown function DUF1747 [IPR013719]", "Domain of unknown function DUF1899 [IPR015048]", "Domain of unknown function DUF3350 [IPR021785]", "Domain of unknown function DUF3385, target of rapamycin protein [IPR024585]", "Domain of unknown function DUF3480 [IPR022557]", "Domain of unknown function DUF3517 [IPR021905]", "Domain of unknown function DUF3677 [IPR022145]", "Domain of unknown function DUF382 [IPR007180]", "Domain of unknown function DUF4042 [IPR025283]", "Domain of unknown function DUF4149 [IPR025423]", "Domain of unknown function DUF4208 [IPR025260]", "Domain of unknown function DUF4217 [IPR025313]", "Domain of unknown function DUF4749 [IPR031847]", "Domain of unknown function DUF5050 [IPR032485]", "Domain of unknown function DUF5595 [IPR040967]", "Domain of unknown function DUF5600 [IPR040990]", "Domain of unknown function DUF5604 [IPR040880]", "Domain of unknown function DUF5921 [IPR045803]", "Domain of unknown function DUF625 [IPR006887]", "Double-stranded RNA-binding domain [IPR014720]", "Down-regulated-in-metastasis protein [IPR011430]", "Drebrin-like protein, SH3 domain [IPR035717]", "Dual specificity phosphatase, catalytic domain [IPR000340]", "Dual specificity protein phosphatase domain [IPR020422]", "Dynamin GTPase effector [IPR003130]", "Dynamin stalk domain [IPR000375]", "Dynamin, GTPase domain [IPR001401]", "Dynamin, N-terminal [IPR045063]", "Dynamin-like GTPase OPA1, C-terminal [IPR045817]", "Dynamin-type guanine nucleotide-binding (G) domain [IPR030381]", "Dynein associated protein [IPR022157]", "Dynein heavy chain AAA lid domain [IPR041658]", "Dynein heavy chain region D6 P-loop domain [IPR004273]", "Dynein heavy chain, AAA 5 extension domain [IPR041466]", "Dynein heavy chain, AAA module D4 [IPR024317]", "Dynein heavy chain, ATP-binding dynein motor region [IPR035706]", "Dynein heavy chain, C-terminal domain [IPR041228]", "Dynein heavy chain, coiled coil stalk [IPR024743]", "Dynein heavy chain, hydrolytic ATP-binding dynein motor region [IPR035699]", "Dynein heavy chain, linker [IPR013602]", "Dynein heavy chain, tail [IPR013594]", "Dyskerin-like [IPR012960]", "E1A-binding protein p400, N-terminal [IPR031575]", "E2 binding [IPR014929]", "E3 Ubiquitin ligase MUL1-like [IPR022170]", "E3 ligase, CCCH-type zinc finger [IPR041367]", "E3 ubiquitin ligase EDD, ubiquitin-associated domain [IPR024725]", "E3 ubiquitin ligase UBR4, C-terminal [IPR025704]", "E3 ubiquitin ligase, domain of unknown function DUF908 [IPR010309]", "E3 ubiquitin ligase, domain of unknown function DUF913 [IPR010314]", "E3 ubiquitin-protein ligase UBR-like, C-terminal [IPR044046]", "E3 ubiquitin-protein ligase UBR4, N-terminal [IPR045841]", "EB1, C-terminal [IPR004953]", "EBP50, C-terminal [IPR015098]", "ECSIT, C-terminal domain [IPR029342]", "EF hand associated, type-1 [IPR013566]", "EF hand associated, type-2 [IPR013567]", "EF-hand domain [IPR002048]", "EF-hand domain, type 1 [IPR015153]", "EF-hand domain, type 2 [IPR015154]", "EF-hand, Ca insensitive [IPR014837]", "EFG, domain V [IPR035649]", "EGF-like calcium-binding domain [IPR001881]", "EGF-like domain [IPR000742]", "EGF-like domain, extracellular [IPR013111]", "EH domain [IPR000261]", "EH domain-containing protein, N-terminal [IPR031692]", "EIF2AK2, first double-stranded RNA binding domain [IPR044452]", "EIF2AK2, second double-stranded RNA binding domain [IPR044453]", "ELK domain [IPR005539]", "ELM2 domain [IPR000949]", "ELMO domain [IPR006816]", "ELMO, armadillo-like helical domain [IPR024574]", "ELYS, beta-propeller domain [IPR032040]", "ELYS-like domain [IPR025151]", "ENTH domain [IPR013809]", "ER membrane protein complex subunit 1, C-terminal [IPR011678]", "ER membrane protein complex subunit 7, beta-sandwich domain [IPR019008]", "ERAP1-like C-terminal domain [IPR024571]", "ERCC3/RAD25/XPB helicase, C-terminal domain [IPR032438]", "ERM family, FERM domain C-lobe [IPR041789]", "ERV/ALR sulfhydryl oxidase domain [IPR017905]", "ERdj5, C-terminal thioredoxin domain [IPR035674]", "ERdj5, first thioredoxin domain [IPR035673]", "ERp29, N-terminal [IPR012883]", "EVE domain [IPR002740]", "EWS, RNA recognition motif [IPR034869]", "EXPERA domain [IPR033118]", "EYA domain [IPR006545]", "EYA domain, metazoan [IPR042577]", "Electron transfer flavoprotein, alpha subunit, C-terminal [IPR014731]", "Electron transfer flavoprotein, alpha subunit, N-terminal [IPR033947]", "Electron transfer flavoprotein, alpha/beta-subunit, N-terminal [IPR014730]", "Electron transfer flavoprotein, beta subunit, N-terminal [IPR033948]", "Elongation Factor G, domain II [IPR041095]", "Elongation factor 1 beta central acidic region, eukaryote [IPR018940]", "Elongation factor 1B gamma, C-terminal [IPR001662]", "Elongation factor 4, domain IV [IPR035654]", "Elongation factor EFG, domain V-like [IPR000640]", "Elongation factor G, domain III [IPR009022]", "Elongation factor Tu (EF-Tu), GTP-binding domain [IPR041709]", "Elongation factor Tu, domain 2 [IPR033720]", "Elp3/MiaB/NifB [IPR006638]", "Emerin, LEM domain [IPR034989]", "Endonuclease/exonuclease/phosphatase [IPR005135]", "Endophilin-A, SH3 domain [IPR035824]", "Endophilin-B1, BAR domain [IPR035695]", "Endoplasmic reticulum resident protein 29, C-terminal [IPR011679]", "Endoplasmic reticulum vesicle transporter, C-terminal [IPR012936]", "Endoplasmic reticulum vesicle transporter, N-terminal [IPR039542]", "Enhancer of mRNA-decapping protein 4, WD40 repeat region [IPR032401]", "Enhancer of polycomb-like, N-terminal [IPR019542]", "Enolase, C-terminal TIM barrel domain [IPR020810]", "Enolase, N-terminal [IPR020811]", "Enoyl-CoA hydratase/isomerase domain [IPR045004]", "Ephrin receptor ligand binding domain [IPR001090]", "Ephrin receptor, transmembrane domain [IPR027936]", "Ephrin type-A receptor 7, ligand binding domain [IPR034283]", "Era-type guanine nucleotide-binding (G) domain [IPR030388]", "Eukaryotic Ribosomal Protein L27, KOW domain [IPR041991]", "Eukaryotic glycogen debranching enzyme, N-terminal domain [IPR029436]", "Eukaryotic translation initiation factor 2D, SUI1 domain [IPR039759]", "Eukaryotic translation initiation factor 3 subunit E, N-terminal [IPR019010]", "Eukaryotic translation initiation factor 3 subunit G, N-terminal [IPR024675]", "Exocyst complex component EXOC2/Sec5, N-terminal domain [IPR039481]", "Exocyst component Exo84, C-terminal [IPR032403]", "Exonuclease 1-like, PIN-like domain [IPR044752]", "Exonuclease, RNase T/DNA polymerase III [IPR013520]", "Exonuclease-1, H3TH domain [IPR037315]", "Exoribonuclease, phosphorolytic domain 1 [IPR001247]", "Exoribonuclease, phosphorolytic domain 2 [IPR015847]", "Exosome complex component CSL4, C-terminal [IPR019495]", "Exosome complex component, N-terminal domain [IPR025721]", "Exosome complex exonuclease RRP44, S1 domain [IPR033770]", "Exosome-associated factor Rrp6, N-terminal [IPR012588]", "Exportin-1, C-terminal [IPR014877]", "Exportin-1/Importin-beta-like [IPR013598]", "Exportin-2, C-terminal [IPR005043]", "Exportin-2, central domain [IPR013713]", "Exportin-5, C-terminal domain [IPR045478]", "Exportin-T, C-terminal domain [IPR045546]", "Extended PHD (ePHD) domain [IPR034732]", "Extended synaptotagmin, C-terminal C2 domain [IPR037752]", "Extended synaptotagmin, C2A domain [IPR037733]", "Extended synaptotagmin, C2B domain [IPR037749]", "Extracellular Endonuclease, subunit A [IPR020821]", "F-BAR domain [IPR031160]", "F-box domain [IPR001810]", "FACT complex subunit POB3-like, N-terminal PH domain [IPR035417]", "FACT complex subunit Spt16 domain [IPR013953]", "FACT complex subunit Spt16, N-terminal lobe domain [IPR029148]", "FACT complex subunit Spt16, peptidase M24-like domain [IPR033825]", "FAD dependent oxidoreductase [IPR006076]", "FAD linked oxidase, N-terminal [IPR006094]", "FAD-binding domain, PCMH-type [IPR016166]", "FAD-binding domain, ferredoxin reductase-type [IPR017927]", "FAD-dependent oxidoreductase 2, FAD binding domain [IPR003953]", "FAD-linked oxidase, C-terminal [IPR004113]", "FAD/NAD(P)-binding domain [IPR023753]", "FAF1, UBA-like domain [IPR044541]", "FAK1/PYK2, FERM domain C-lobe [IPR041784]", "FAM192A/Fyv6, N-terminal [IPR019331]", "FANCI helical domain 1 [IPR029310]", "FANCI helical domain 2 [IPR029312]", "FANCI solenoid 1 cap [IPR029305]", "FANCI solenoid 1 domain [IPR029308]", "FANCI solenoid 2 domain [IPR029315]", "FANCI solenoid 3 domain [IPR029313]", "FANCI solenoid 4 domain [IPR029314]", "FARP1/FARP2/FRMD7, FERM domain C-lobe [IPR041788]", "FAS-associated factor 1-like, UBX domain [IPR033043]", "FAST kinase leucine-rich [IPR010622]", "FAST kinase-like protein, subdomain 2 [IPR013579]", "FATC domain [IPR003152]", "FCH domain [IPR001060]", "FCP1 homology domain [IPR004274]", "FDF domain [IPR019050]", "FERM adjacent (FA) [IPR014847]", "FERM central domain [IPR019748]", "FERM domain [IPR000299]", "FERM, C-terminal PH-like domain [IPR018980]", "FERM, N-terminal [IPR018979]", "FF domain [IPR002713]", "FFD box [IPR025761]", "FGFR1 oncogene partner (FOP), N-terminal dimerisation domain [IPR018993]", "FHOD1, N-terminal GTPase-binding domain [IPR041387]", "FKBP-type peptidyl-prolyl cis-trans isomerase domain [IPR001179]", "FKBP12-rapamycin binding domain [IPR009076]", "FKBP3, basic tilted helix bundle domain [IPR041200]", "FY-rich, C-terminal [IPR003889]", "FY-rich, N-terminal [IPR003888]", "FYVE zinc finger [IPR000306]", "Far upstream element-binding protein, C-terminal [IPR015096]", "Far11/STRP, C-terminal [IPR021819]", "Far11/STRP, N-terminal [IPR012486]", "Fascin domain [IPR022768]", "Fatty acid desaturase domain [IPR005804]", "Fatty acid hydroxylase [IPR006694]", "Fatty acyl-CoA reductase, C-terminal [IPR033640]", "Fatty acyl-coenzyme A reductase, NAD-binding domain [IPR013120]", "Fcf2 pre-rRNA processing, C-terminal [IPR014810]", "Ferrochelatase, C-terminal [IPR033644]", "Ferrochelatase, N-terminal [IPR033659]", "Fibronectin type II domain [IPR000562]", "Fibronectin type III [IPR003961]", "Fibronectin type III and SPRY containing 1, PRY/SPRY domain [IPR035742]", "First polo-box domain [IPR033701]", "Flavodoxin-like [IPR001094]", "Flavodoxin/nitric oxide synthase [IPR008254]", "Flavoprotein [IPR003382]", "Flavoprotein pyridine nucleotide cytochrome reductase [IPR001709]", "Flavoprotein pyridine nucleotide cytochrome reductase-like, FAD-binding domain [IPR008333]", "Focadhesin/RST, DUF3730 [IPR022542]", "Focal adhesion kinase, N-terminal [IPR041390]", "Focal adhesion kinase, targeting (FAT) domain [IPR005189]", "Follistatin-like, N-terminal [IPR003645]", "Fork head domain [IPR001766]", "Forkhead-associated (FHA) domain [IPR000253]", "Formin, FH2 domain [IPR015425]", "Formin, FH3 domain [IPR010472]", "Formin, GTPase-binding domain [IPR010473]", "Formyl transferase, N-terminal [IPR002376]", "Fragile X-related 1 protein, C-terminal core [IPR022034]", "Fragile X-related 1 protein, C-terminal region 1 [IPR032172]", "Fragile X-related 1 protein, C-terminal region 3 [IPR032177]", "Fragile X-related mental retardation protein, C-terminal region 2 [IPR032196]", "Freud, C2 domain [IPR037772]", "Fumarase C, C-terminal [IPR018951]", "Fumarate lyase, N-terminal [IPR022761]", "Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal [IPR015939]", "Fumarylacetoacetase, N-terminal [IPR015377]", "Fumarylacetoacetase-like, C-terminal [IPR011234]", "Fungal lipase-like domain [IPR002921]", "Fxr1, tudor domain [IPR041560]", "Fzo/mitofusin HR2 domain [IPR006884]", "G-patch domain [IPR000467]", "G-patch domain and KOW motifs-containing protein, KOW 1 [IPR041993]", "G-patch domain and KOW motifs-containing protein, KOW 2 [IPR041994]", "G-protein gamma-like domain [IPR015898]", "G-protein, beta subunit [IPR001632]", "G3BP1, RNA recognition motif [IPR034374]", "G3BP2, RNA recognition motif [IPR034376]", "GAD domain [IPR029351]", "GAR domain [IPR003108]", "GAT domain [IPR004152]", "GB1/RHD3-type guanine nucleotide-binding (G) domain [IPR030386]", "GCF, C-terminal [IPR022783]", "GH15-like domain [IPR011613]", "GHMP kinase N-terminal domain [IPR006204]", "GHMP kinase, C-terminal domain [IPR013750]", "GINS complex protein Sld5, alpha-helical domain [IPR038749]", "GINS subunit, domain A [IPR021151]", "GMP synthase, C-terminal [IPR001674]", "GMP synthase, glutamine amidotransferase [IPR004739]", "GMP synthetase ATP pyrophosphatase domain [IPR025777]", "GNAT domain [IPR000182]", "GOLD domain [IPR009038]", "GPAT/DHAPAT, acyltransferase domain [IPR041728]", "GPI ethanolamine phosphate transferase 2, C-terminal [IPR045687]", "GPI ethanolamine phosphate transferase 2, N-terminal [IPR037674]", "GPR domain [IPR000965]", "GRAM domain [IPR004182]", "GRASP-type PDZ domain [IPR024958]", "GRB2, C-terminal SH3 domain [IPR035643]", "GRB2, N-terminal SH3 domain [IPR035641]", "GRSF-1, RNA recognition motif 1 [IPR034425]", "GRSF-1, RNA recognition motif 2 [IPR034424]", "GRSF-1, RNA recognition motif 3 [IPR034426]", "GTP binding domain [IPR006073]", "GTP binding protein 1-like, GTP-binding domain [IPR035531]", "GTP binding protein, second domain [IPR031662]", "GTP-binding protein LepA, C-terminal [IPR013842]", "GTP-binding protein TrmE, N-terminal [IPR018948]", "GTP1/OBG domain [IPR006169]", "GTPase effector domain [IPR020850]", "GUCT [IPR012562]", "GYF domain 2 [IPR025640]", "GYF domain [IPR003169]", "Galactokinase, N-terminal domain [IPR019539]", "Galactose mutarotase, N-terminal barrel [IPR031727]", "Galectin, carbohydrate recognition domain [IPR001079]", "Gamma tubulin complex component protein, N-terminal [IPR041470]", "Gamma tubulin complex component, C-terminal [IPR040457]", "Gamma-adaptin ear (GAE) domain [IPR008153]", "Gamma-butyrobetaine hydroxylase-like, N-terminal [IPR010376]", "Gamma-glutamyl cyclotransferase-like [IPR013024]", "Gcp-like domain [IPR000905]", "Gelsolin-like domain [IPR007123]", "Gfo/Idh/MocA-like oxidoreductase, N-terminal [IPR000683]", "Gid-type RING finger domain [IPR044063]", "GlmS/AgaS, SIS domain 1 [IPR035466]", "GlmS/FrlB, SIS domain 2 [IPR035490]", "Glucosamine/galactosamine-6-phosphate isomerase [IPR006148]", "Glucose-6-phosphate dehydrogenase, C-terminal [IPR022675]", "Glucose-6-phosphate dehydrogenase, NAD-binding [IPR022674]", "Glucose-methanol-choline oxidoreductase, C-terminal [IPR007867]", "Glucose-methanol-choline oxidoreductase, N-terminal [IPR000172]", "Glucosidase 2 subunit beta-like [IPR036607]", "Glucosidase II beta subunit, N-terminal [IPR028146]", "Glucosyltransferase 24, catalytic domain [IPR040497]", "Glutamate/phenylalanine/leucine/valine dehydrogenase, C-terminal [IPR006096]", "Glutamate/phenylalanine/leucine/valine dehydrogenase, dimerisation domain [IPR006097]", "Glutaminase, EF-hand domain [IPR041541]", "Glutamine amidotransferase [IPR017926]", "Glutamine amidotransferase type 2 domain [IPR017932]", "Glutamine-Leucine-Glutamine, QLQ [IPR014978]", "Glutaminyl-tRNA synthetase, class Ib, non-specific RNA-binding domain 2 [IPR007638]", "Glutaminyl-tRNA synthetase, class Ib, non-specific RNA-binding domain, N-terminal [IPR007639]", "Glutamyl-tRNA synthetase [IPR033910]", "Glutamyl/glutaminyl-tRNA synthetase, class Ib, anti-codon binding domain [IPR020059]", "Glutamyl/glutaminyl-tRNA synthetase, class Ib, catalytic domain [IPR020058]", "Glutaredoxin [IPR002109]", "Glutaredoxin, PICOT-like [IPR033658]", "Glutathione S-transferase, C-terminal [IPR004046]", "Glutathione S-transferase, C-terminal-like [IPR010987]", "Glutathione S-transferase, N-terminal [IPR004045]", "Glutathione S-transferases, class Zeta , C-terminal [IPR034330]", "Glutathione S-transferases, class Zeta , N-terminal [IPR034333]", "Glutathione synthase, substrate-binding domain [IPR004887]", "Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain [IPR020828]", "Glyceraldehyde 3-phosphate dehydrogenase, catalytic domain [IPR020829]", "Glycerol-3-phosphate acyltransferase-like, C-terminal domain [IPR045520]", "Glycerol-3-phosphate dehydrogenase, NAD-dependent, C-terminal [IPR006109]", "Glycerol-3-phosphate dehydrogenase, NAD-dependent, N-terminal [IPR011128]", "Glycerophosphodiester phosphodiesterase domain [IPR030395]", "Glycogen debranching enzyme, C-terminal [IPR032790]", "Glycogen debranching enzyme, central domain [IPR032788]", "Glycogen debranching enzyme, glucanotransferase domain [IPR032792]", "Glycogen synthase kinase 3, catalytic domain [IPR039192]", "Glycolipid transfer protein domain [IPR014830]", "Glycoside hydrolase 35, catalytic domain [IPR031330]", "Glycoside hydrolase family 18, catalytic domain [IPR001223]", "Glycoside hydrolase family 20, catalytic domain [IPR015883]", "Glycoside hydrolase family 31, N-terminal domain [IPR025887]", "Glycoside hydrolase family 38, N-terminal domain [IPR000602]", "Glycoside hydrolase family 38, central domain [IPR015341]", "Glycosyl hydrolase family 30, TIM-barrel domain [IPR033453]", "Glycosyl hydrolase family 30, beta sandwich domain [IPR033452]", "Glycosyl hydrolase family 38, C-terminal [IPR011682]", "Glycosyl hydrolase family 63, C-terminal [IPR031335]", "Glycosyl hydrolase family 63, N-terminal [IPR031631]", "Glycosyl hydrolase, family 13, catalytic domain [IPR006047]", "Glycosyl hydrolases family 38, C-terminal beta sandwich domain [IPR041147]", "Glycosyl transferase CAP10 domain [IPR006598]", "Glycosyl transferase, family 1 [IPR001296]", "Glycosyltransferase 2-like [IPR001173]", "Glycyl-tRNA synthetase-like core domain [IPR033731]", "Glyoxalase domain-containing protein 4, C-terminal [IPR043194]", "Glyoxalase/fosfomycin resistance/dioxygenase domain [IPR004360]", "Golgi pH regulator, conserved domain [IPR022535]", "Golgin subfamily A, conserved domain [IPR043976]", "Groucho/TLE, N-terminal Q-rich domain [IPR005617]", "Growth hormone-inducible transmembrane protein [IPR035871]", "Guanine nucleotide exchange factor, N-terminal [IPR032691]", "Guanine nucleotide-binding protein-like 3, N-terminal domain [IPR014813]", "Guanylate kinase-like domain [IPR008144]", "Guanylate kinase/L-type calcium channel beta subunit [IPR008145]", "Guanylate-binding protein, N-terminal [IPR015894]", "Guanylate-binding protein/Atlastin, C-terminal [IPR003191]", "HAD-superfamily hydrolase, subfamily IIID [IPR011943]", "HAD-superfamily hydrolase,subfamily IIIA [IPR006549]", "HAUS augmin-like complex subunit 3, N-terminal [IPR032733]", "HAUS augmin-like complex subunit 6, N-terminal [IPR028163]", "HBS1-like protein, N-terminal [IPR015033]", "HD domain [IPR006674]", "HD/PDEase domain [IPR003607]", "HDGF-related, PWWP domain [IPR035496]", "HECT domain [IPR000569]", "HELLS, N-terminal [IPR044753]", "HELP [IPR005108]", "HHH domain 9 [IPR041692]", "HIRAN domain [IPR014905]", "HIT-like domain [IPR011146]", "HOOK, N-terminal [IPR043936]", "HR1 rho-binding domain [IPR011072]", "HRDC domain [IPR002121]", "HSPA4, nucleotide-binding domain [IPR042052]", "HSPA4L, nucleotide-binding domain [IPR042708]", "HSPH1, nucleotide-binding domain [IPR042053]", "HTH CenpB-type DNA-binding domain [IPR006600]", "HTTM [IPR011020]", "HUWE1, UBA domain [IPR041918]", "Heat shock 70kDa protein 14, nucleotide-binding domain [IPR042049]", "Heat shock chaperonin-binding [IPR006636]", "Heat shock protein DnaJ, cysteine-rich domain [IPR001305]", "Heat shock protein Hsp90, N-terminal [IPR020575]", "Heavy metal-associated domain, HMA [IPR006121]", "Heavy metal-associated domain, copper ion-binding [IPR006122]", "Helical and beta-bridge domain [IPR010643]", "Helicase XPB/Ssl2, N-terminal domain [IPR032830]", "Helicase domain [IPR007807]", "Helicase superfamily 1/2, ATP-binding domain [IPR014001]", "Helicase superfamily 1/2, ATP-binding domain, DinG/Rad3-type [IPR014013]", "Helicase, C-terminal [IPR001650]", "Helicase-associated domain [IPR007502]", "Helicase-like, DEXD box c2 type [IPR006554]", "Helicase/SANT-associated domain [IPR014012]", "Helicase/UvrB, N-terminal [IPR006935]", "Helix-hairpin-helix DNA-binding motif, class 1 [IPR003583]", "Helix-turn-helix DNA-binding domain of Spt6 [IPR028088]", "Hemimethylated DNA-binding domain [IPR011722]", "Hepatitis delta antigen (HDAg) domain [IPR037517]", "Hepatocyte growth factor-regulated tyrosine kinase substrate, helical domain [IPR024641]", "Heterogeneous nuclear ribonucleoprotein Q acidic domain [IPR041337]", "Heterogeneous nuclear ribonucleoprotein Q, RNA recognition motif 1 [IPR034544]", "Heterogeneous nuclear ribonucleoprotein Q, RNA recognition motif 2 [IPR034548]", "Heterogeneous nuclear ribonucleoprotein R, RNA recognition motif 2 [IPR034411]", "Heterogeneous nuclear ribonucleoprotein U, SPRY domain [IPR035778]", "Hexokinase, C-terminal [IPR022673]", "Hexokinase, N-terminal [IPR022672]", "HhH-GPD domain [IPR003265]", "High mobility group box domain 5 [IPR029215]", "High mobility group box domain [IPR009071]", "Histidine kinase domain [IPR005467]", "Histidine kinase/HSP90-like ATPase [IPR003594]", "Histidyl-anticodon-binding [IPR033656]", "Histone H2A, C-terminal domain [IPR032454]", "Histone H2A/H2B/H3 [IPR007125]", "Histone acetyl transferase HAT1 N-terminal [IPR019467]", "Histone acetyltransferase domain, MYST-type [IPR002717]", "Histone chaperone domain CHZ [IPR019098]", "Histone deacetylase complex subunit SAP130, C-terminal domain [IPR031963]", "Histone deacetylase domain [IPR023801]", "Histone deacetylase interacting domain [IPR013194]", "Histone methyltransferase, Tudor domain 1 [IPR041291]", "Histone methyltransferase, Tudor domain 2 [IPR041292]", "Histone-binding protein RBBP4, N-terminal [IPR022052]", "HnRNP M, nuclear localisation signal [IPR024666]", "Homeobox domain [IPR001356]", "Homocysteine-binding domain [IPR003726]", "Hook, C-terminal [IPR008636]", "Hotdog acyl-CoA thioesterase (ACOT)-type domain [IPR033120]", "HuR, RNA recognition motif 2 [IPR034996]", "Hyaluronan-mediated motility receptor, C-terminal [IPR031794]", "Hyaluronan/mRNA-binding protein [IPR006861]", "Hydroxymethylglutaryl-coenzyme A synthase, C-terminal domain [IPR013746]", "Hydroxymethylglutaryl-coenzyme A synthase, N-terminal [IPR013528]", "I-kappa-kinase-beta NEMO binding domain [IPR022007]", "I/LWEQ domain [IPR002558]", "IBR domain [IPR002867]", "IF2a, S1-like domain [IPR044126]", "IFT81, calponin homology domain [IPR041146]", "IGF2BP1, RNA recognition motif 1 [IPR034837]", "IGF2BP1, RNA recognition motif 2 [IPR034842]", "IGF2BP2, RNA recognition motif 1 [IPR034843]", "IGF2BP3, RNA recognition motif 2 [IPR034844]", "IKBKB, scaffold dimerization domain [IPR041185]", "IMD/I-BAR domain [IPR013606]", "IMP dehydrogenase/GMP reductase [IPR001093]", "IPS1, CARD domain [IPR042144]", "IPT domain [IPR002909]", "IRG-type guanine nucleotide-binding (G) domain [IPR030385]", "IRS-type PTB domain [IPR002404]", "IRSp53, SH3 domain [IPR035594]", "ISG20, DEDDh 3'-5' exonuclease domain [IPR037433]", "ISWI, HAND domain [IPR015194]", "Ima1, N-terminal domain [IPR018617]", "Immunoglobulin C1-set [IPR003597]", "Immunoglobulin I-set [IPR013098]", "Immunoglobulin V-set domain [IPR013106]", "Immunoglobulin [IPR013151]", "Immunoglobulin subtype 2 [IPR003598]", "Immunoglobulin subtype [IPR003599]", "Immunoglobulin-like domain [IPR007110]", "Importin-alpha, importin-beta-binding domain [IPR002652]", "Importin-beta, N-terminal domain [IPR001494]", "Initiation factor eIF-4 gamma, MA3 [IPR003891]", "Inositol 1,3,4-trisphosphate 5/6-kinase, ATP-grasp domain [IPR040464]", "Inositol polyphosphate 5-phosphatase, clathrin binding domain [IPR031995]", "Inositol polyphosphate-related phosphatase [IPR000300]", "Inositol-tetrakisphosphate 1-kinase, N-terminal [IPR041429]", "Integrator complex subunit 11, MBL-fold [IPR041897]", "Integrator complex subunit 14, C-terminal [IPR045814]", "Integrator complex subunit 3, N-terminal [IPR019333]", "Integrin beta N-terminal [IPR033760]", "Integrin beta subunit, VWA domain [IPR002369]", "Integrin beta subunit, cytoplasmic domain [IPR014836]", "Integrin beta subunit, tail [IPR012896]", "Integrin beta, epidermal growth factor-like domain 1 [IPR040622]", "Integrin-linked protein kinase, pseudokinase domain [IPR035692]", "Interferon regulatory factor 2-binding protein 1 & 2, zinc finger [IPR022750]", "Intermediate filament head, DNA-binding domain [IPR006821]", "Intermediate filament, rod domain [IPR039008]", "Intersectin-2, fifth SH3 domain [IPR035741]", "Intersectin-2, first SH3 domain [IPR035737]", "Intersectin-2, fourth SH3 domain [IPR035740]", "Intersectin-2, second SH3 domain [IPR035738]", "Intersectin-2, third SH3 domain [IPR035739]", "Intracellular hyaluronan-binding protein 4, N-terminal domain [IPR032381]", "Intron-binding protein aquarius, N-terminal [IPR032174]", "Ion transporter-like, CBS domain [IPR044751]", "Iron sulphur domain-containing, mitoNEET, N-terminal [IPR019610]", "Iron-binding zinc finger, CDGSH type [IPR018967]", "Isochorismatase-like [IPR000868]", "Isoleucyl tRNA synthetase type 1, anticodon-binding domain [IPR033708]", "Isoleucyl tRNA synthetase type 2, anticodon-binding domain [IPR033709]", "Isopenicillin N synthase-like, Fe(2+) 2OG dioxygenase domain [IPR044861]", "Isopropylmalate dehydrogenase-like domain [IPR024084]", "JAB1/MPN/MOV34 metalloenzyme domain [IPR000555]", "JNK-interacting protein, leucine zipper II [IPR032486]", "JNK/Rab-associated protein-1, N-terminal [IPR019143]", "JmjC domain [IPR003347]", "JmjN domain [IPR003349]", "Jumonji, helical domain [IPR041070]", "K Homology domain [IPR004087]", "K Homology domain, type 1 [IPR004088]", "K Homology domain, type 2 [IPR004044]", "KAP family P-loop domain [IPR011646]", "KASH domain [IPR012315]", "KHDRBS, Qua1 domain [IPR032571]", "KMT2A, PHD domain 1 [IPR042023]", "KMT2A, PHD domain 2 [IPR042025]", "KMT2A, PHD domain 3 [IPR044133]", "KMT2A, ePHD domain [IPR041958]", "KN17, SH3-like C-terminal domain [IPR041330]", "KOW [IPR005824]", "Kin17, KOW domain [IPR041995]", "Kindlin-2, N-terminal [IPR040790]", "Kindlin/fermitin, PH domain [IPR037837]", "Kinesin motor domain [IPR001752]", "Kinesin-associated [IPR032405]", "Kinesin-associated microtubule-binding domain [IPR025901]", "Kinesin-like KIF1-type [IPR022140]", "Kinesin-like [IPR022164]", "Kinesin-like protein Kif23, Arf6-interacting domain [IPR032384]", "Kinetochore protein Nuf2, N-terminal [IPR005549]", "Kri1-like, C-terminal [IPR024626]", "Krr1, KH1 domain [IPR041174]", "Ku, C-terminal [IPR014893]", "Ku70/Ku80 C-terminal arm [IPR005160]", "Ku70/Ku80 beta-barrel domain [IPR006164]", "Ku70/Ku80, N-terminal alpha/beta [IPR005161]", "L27 domain [IPR004172]", "L27 domain, C-terminal [IPR014775]", "L27-1 [IPR015143]", "LAIKA domain [IPR045353]", "LARP4, RNA recognition motif [IPR034903]", "LARP5, RNA recognition motif [IPR034900]", "LARP7, RNA recognition motif 1 [IPR034887]", "LARP7, RNA recognition motif 2 [IPR034910]", "LEM domain [IPR003887]", "LEM-like domain [IPR013146]", "LETM1, ribosome-binding domain [IPR033122]", "LETM1-like [IPR011685]", "LIN-9, C-terminal [IPR045831]", "LIS1 homology motif [IPR006594]", "LRRC8, pannexin-like TM region [IPR021040]", "LSM domain, eukaryotic/archaea-type [IPR001163]", "LSM-interacting domain [IPR008669]", "La protein, xRRM domain [IPR014886]", "La-related protein 7, La domain [IPR034946]", "La-type HTH domain [IPR006630]", "Lactate/malate dehydrogenase, C-terminal [IPR022383]", "Lactate/malate dehydrogenase, N-terminal [IPR001236]", "Lamin tail domain [IPR001322]", "Lamin-B receptor of TUDOR domain [IPR019023]", "Lamina-associated polypeptide 2 alpha, C-terminal [IPR021623]", "Laminin G domain [IPR001791]", "Laminin IV [IPR000034]", "Laminin IV type B [IPR013015]", "Laminin, N-terminal [IPR008211]", "Laminin-type EGF domain [IPR002049]", "Large proline-rich protein BAG6 [IPR021925]", "Lasp1, SH3 domain [IPR035630]", "Legume-like lectin [IPR005052]", "Lens epithelium-derived growth factor, integrase-binding domain [IPR021567]", "Lethal giant larvae homologue 2 [IPR013577]", "Leucine zipper, homeobox-associated [IPR003106]", "Leucine-rich repeat N-terminal domain [IPR000372]", "Leukocyte surface antigen CD47, IgV [IPR037805]", "Linker histone H1/H5, domain H15 [IPR005818]", "Liprin-alpha, SAM domain repeat 1 [IPR037620]", "Liprin-alpha, SAM domain repeat 2 [IPR037621]", "Liprin-alpha, SAM domain repeat 3 [IPR037622]", "Listerin, zinc finger, RING-type [IPR039804]", "Lon, substrate-binding domain [IPR003111]", "Longin domain [IPR010908]", "Lsm14-like, N-terminal [IPR025609]", "Lsm16, N-terminal [IPR034107]", "LsmAD domain [IPR009604]", "Lunapark domain [IPR019273]", "Lysine-specific demethylase-like domain [IPR013637]", "Lysine-tRNA ligase, class II, N-terminal [IPR044136]", "Lysophosphatidylcholine acyltransferase LPCAT1-like [IPR045252]", "Lysyl-tRNA synthetase, class II, C-terminal [IPR018149]", "M60-like domain, N-terminal [IPR035423]", "MAGE homology domain [IPR002190]", "MALT1 immunoglobulin-like domain [IPR041077]", "MALT1, death domain [IPR037940]", "MAM domain [IPR000998]", "MAN1, RNA recognition motif [IPR034394]", "MANSC domain [IPR013980]", "MATH/TRAF domain [IPR002083]", "MCM N-terminal domain [IPR027925]", "MCM OB domain [IPR033762]", "MCM domain [IPR001208]", "MCM, AAA-lid domain [IPR041562]", "MD-2-related lipid-recognition domain [IPR003172]", "MDM2-binding protein, N-terminal domain [IPR029421]", "MDM2-binding protein, central domain [IPR029420]", "MDN2-binding protein, C-terminal domain [IPR029418]", "MEF-2, RNA recognition motif 1 [IPR034630]", "MEF-2, RNA recognition motif 3 [IPR034631]", "MHC class I alpha chain, alpha1 alpha2 domains [IPR001039]", "MHC class I, alpha chain, C-terminal [IPR010579]", "MHC class I-like antigen recognition-like [IPR011161]", "MIA2, SH3 domain [IPR035555]", "MIF4G-like, type 1 [IPR015172]", "MIF4G-like, type 2 [IPR015174]", "MIF4G-like, type 3 [IPR003890]", "MIRO domain [IPR020860]", "MIT domain [IPR007330]", "MKI67 FHA domain-interacting nucleolar phosphoprotein, FHA Ki67 binding [IPR021043]", "MMS19, C-terminal [IPR024687]", "MMS19, N-terminal [IPR029240]", "MOSC, N-terminal beta barrel [IPR005303]", "MPN domain [IPR037518]", "MPP1, SH3 domain [IPR035475]", "MPP2, SH3 domain [IPR035602]", "MPP6, SH3 domain [IPR035603]", "MPP7, SH3 domain [IPR035599]", "MRG domain [IPR026541]", "MRH domain [IPR044865]", "MRPL44, double-stranded RNA binding domain [IPR044444]", "MST4, kinase domain [IPR035056]", "MTMR14, PH-GRAM domain [IPR039803]", "MTMR6, PH-GRAM domain [IPR035998]", "MYND-like zinc finger [IPR031615]", "MYST, zinc finger domain [IPR040706]", "Mab-21 domain [IPR024810]", "Macro domain [IPR002589]", "Mad3/Bub1 homology region 1 [IPR013212]", "Major facilitator superfamily domain [IPR020846]", "Major sperm protein (MSP) domain [IPR000535]", "Malectin domain [IPR021720]", "Malic enzyme, N-terminal domain [IPR012301]", "Malic enzyme, NAD-binding [IPR012302]", "Man1/Src1, C-terminal [IPR018996]", "Manganese/iron superoxide dismutase, C-terminal [IPR019832]", "Manganese/iron superoxide dismutase, N-terminal [IPR019831]", "MaoC-like dehydratase domain [IPR002539]", "Marvel domain [IPR008253]", "Matrin-3, RNA recognition motif 1 [IPR034928]", "Matrin-3, RNA recognition motif 2 [IPR034930]", "Matrin/U1-C, C2H2-type zinc finger [IPR000690]", "Matrin/U1-C-like, C2H2-type zinc finger [IPR003604]", "Mcm6, C-terminal winged-helix domain [IPR041024]", "Membrane insertase YidC/Oxa1, C-terminal [IPR028055]", "Metallo-beta-lactamase [IPR001279]", "Metastasis-associated protein MTA1, R1 domain [IPR035170]", "Metaxin, glutathione S-transferase domain [IPR033468]", "Methionine synthase, B12-binding domain [IPR033706]", "Methionine--tRNA ligase, N-terminal [IPR041598]", "Methioninyl-tRNA synthetase core domain [IPR033911]", "Methionyl-tRNA synthetase, anticodon-binding domain [IPR041872]", "Methionyl/Leucyl tRNA synthetase [IPR015413]", "Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding [IPR013155]", "Methyl-CpG DNA binding [IPR001739]", "Methyl-CpG binding protein 2/3, C-terminal domain [IPR025884]", "Methyl-CpG-binding domain protein 2/3, p55-binding region [IPR032343]", "Methylglyoxal synthase-like domain [IPR011607]", "Methylmalonyl-CoA mutase, C-terminal [IPR006159]", "Methylmalonyl-CoA mutase, alpha chain, catalytic [IPR006098]", "Methylmalonyl-CoA mutase, alpha/beta chain, catalytic [IPR006099]", "Methylthiotransferase, N-terminal [IPR013848]", "Methyltransferase domain 25 [IPR041698]", "Methyltransferase domain [IPR025714]", "Methyltransferase type 11 [IPR013216]", "Methyltransferase type 12 [IPR013217]", "MgsA AAA+ ATPase C-terminal [IPR021886]", "Mib-herc2 [IPR010606]", "Midasin AAA lid domain 5 [IPR041190]", "Midasin, AAA lid domain 7 [IPR040848]", "Minichromosome loss protein Mcl1, middle region [IPR022100]", "Misato Segment II tubulin-like domain [IPR019605]", "Mitochondria fission protein Fis1, cytosolic domain [IPR033745]", "Mitochondrial ABC-transporter, N-terminal five TM domain [IPR032410]", "Mitochondrial apoptosis-inducing factor, C-terminal domain [IPR029324]", "Mitochondrial cytochrome c oxidase subunit VIc/VIIs [IPR034884]", "Mitochondrial degradasome RNA helicase subunit, C-terminal domain [IPR022192]", "Mitochondrial outer membrane transport complex Sam37/metaxin, N-terminal domain [IPR019564]", "Mitochondrial ribosomal protein L46 NUDIX [IPR033650]", "MnmE, helical domain [IPR025867]", "MnmG, N-terminal domain [IPR040131]", "MoaB/Mog domain [IPR001453]", "Modifier of rudimentary, Modr [IPR009851]", "MoeA, C-terminal, domain IV [IPR005111]", "MoeA, N-terminal and linker domain [IPR005110]", "Molybdenum cofactor sulfurase, C-terminal [IPR005302]", "Molybdopterin oxidoreductase [IPR006656]", "Molybdopterin oxidoreductase, 4Fe-4S domain [IPR006963]", "Mon2, C-terminal [IPR032817]", "Mon2, dimerisation and cyclophilin-binding domain [IPR032629]", "Morc, S5 domain 2-like [IPR041006]", "Mot1, ATP-binding domain [IPR044078]", "Mot1, central domain [IPR022707]", "Mre11 nuclease, N-terminal metallophosphatase domain [IPR041796]", "Mre11, DNA-binding [IPR007281]", "Mst1 SARAH domain [IPR024205]", "Mu homology domain [IPR028565]", "Mu2, C-terminal domain [IPR043512]", "Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal [IPR031717]", "Multiple myeloma tumor-associated protein 2-like, N-terminal [IPR019315]", "Multiprotein bridging factor 1, N-terminal [IPR013729]", "Muskelin, N-terminal [IPR010565]", "Mvd1, C-terminal [IPR041431]", "Myb domain [IPR017930]", "Myo-inositol-1-phosphate synthase, GAPDH-like [IPR013021]", "Myosin VI, cargo binding domain [IPR032412]", "Myosin head, motor domain [IPR001609]", "Myosin phosphatase-RhoA interacting protein, PH domain [IPR039597]", "Myosin tail [IPR002928]", "Myosin, N-terminal, SH3-like [IPR004009]", "Myotubularin-like phosphatase domain [IPR010569]", "Myristoyl-CoA:protein N-myristoyltransferase, C-terminal [IPR022677]", "Myristoyl-CoA:protein N-myristoyltransferase, N-terminal [IPR022676]", "N-CoR, GPS2-interacting domain [IPR031557]", "N-acetylgalactosaminyltransferase [IPR045885]", "N-acetylneuraminic acid synthase, N-terminal [IPR013132]", "N-terminal extension of GAT domain [IPR041198]", "NACHT nucleoside triphosphatase [IPR007111]", "NAD(P) binding domain of glutamate dehydrogenase [IPR033922]", "NAD(P) transhydrogenase, alpha subunit, C-terminal [IPR024605]", "NAD-dependent epimerase/dehydratase [IPR001509]", "NAD/GMP synthase [IPR022310]", "NADH-quinone oxidoreductase, chain G, C-terminal [IPR015405]", "NADH-quinone oxidoreductase, subunit D [IPR001135]", "NADH-ubiquinone oxidoreductase 51kDa subunit, FMN-binding domain [IPR011538]", "NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain [IPR019575]", "NADH:ubiquinone oxidoreductase, 30kDa subunit [IPR001268]", "NADH:ubiquinone oxidoreductase, subunit G, iron-sulphur binding [IPR019574]", "NADH:ubiquinone oxidoreductase-like, 20kDa subunit [IPR006137]", "NADP transhydrogenase beta-like domain [IPR034300]", "NADP-dependent oxidoreductase domain [IPR023210]", "NDUFB9, LYR domain [IPR045292]", "NECAP, PHear domain [IPR012466]", "NEDD8 ultimate buster 1, ubiquitin-like domain [IPR041207]", "NET domain [IPR027353]", "NF-kappaB-repression factor, R3H domain [IPR034071]", "NFACT protein, C-terminal [IPR021846]", "NFACT, RNA-binding domain [IPR008532]", "NGN domain [IPR005100]", "NGN domain, eukaryotic [IPR039385]", "NHL2, NHL repeat domain [IPR045302]", "NIF system FeS cluster assembly, NifU, C-terminal [IPR001075]", "NIPSNAP [IPR012577]", "NLE [IPR012972]", "NOG, C-terminal [IPR012973]", "NOG1, N-terminal helical domain [IPR041623]", "NOP5, N-terminal [IPR012974]", "NOPS [IPR012975]", "NOSIC [IPR012976]", "NOT4, modified RING finger, HC subclass (C4C4-type) [IPR039515]", "NP60, PWWP domain [IPR035501]", "NPL4, zinc-binding putative [IPR007716]", "NSD, Cys-His rich domain [IPR041306]", "NT-type C2 domain [IPR019448]", "NUC153 [IPR012580]", "NUC205 domain [IPR012584]", "NUDIX hydrolase [IPR020476]", "NUDIX hydrolase domain [IPR000086]", "NVL2, nucleolin binding domain [IPR031996]", "Nascent polypeptide-associated complex NAC domain [IPR002715]", "Negative elongation factor E, RNA recognition motif [IPR034637]", "Neurobeachin-like, DUF1088 [IPR010508]", "Neurobeachin/BDCP, DUF4704 [IPR031570]", "Neuroblastoma-amplified sequence, N-terminal [IPR029145]", "Neuropilin, C-terminal [IPR022579]", "Nibrin, second BRCT domain [IPR032429]", "Nicastrin, small lobe [IPR041084]", "Nicotinamide phosphoribosyltransferase, N-terminal domain [IPR041529]", "Nicotinate/nicotinamide phosphoribosyltransferase [IPR041525]", "Niemann-Pick C1, N-terminal [IPR032190]", "Nin one binding (NOB1) Zn-ribbon-like [IPR014881]", "Nischarin, PX domain [IPR037904]", "Nit1/2, carbon-nitrogen hydrolase domain [IPR045254]", "Nitric oxide synthase-interacting protein, zinc-finger [IPR031790]", "Non-canonical purine NTP phosphatase/PRRC1 [IPR026533]", "Nop domain [IPR002687]", "Nop2p [IPR011023]", "Notch domain [IPR000800]", "Notch, C-terminal [IPR024600]", "Notch, NOD domain [IPR010660]", "Notch, NODP domain [IPR011656]", "Npc2 like, ML domain [IPR033916]", "Nrap protein domain 1 [IPR035082]", "Nrap protein, domain 2 [IPR035367]", "Nrap protein, domain 3 [IPR035368]", "Nrap protein, domain 4 [IPR035369]", "Nrap protein, domain 5 [IPR035370]", "Nrap protein, domain 6 [IPR035371]", "Nuclear RNA export factor Tap, RNA-binding domain [IPR015245]", "Nuclear condensin complex subunit 3, C-terminal domain [IPR025977]", "Nuclear migration protein nudC [IPR032572]", "Nuclear pore complex protein Nup214, phenylalanine-glycine (FG) domain [IPR041553]", "Nuclear pore complex, NUP2/50/61 [IPR015007]", "Nuclear pore localisation protein NPL4, C-terminal [IPR007717]", "Nuclear pore localisation protein Npl4, ubiquitin-like domain [IPR024682]", "Nuclear protein 96 [IPR021967]", "Nuclear transport factor 2 domain [IPR002075]", "Nuclear transport factor 2, eukaryote [IPR018222]", "Nucleolar GTP-binding protein 1, Rossman-fold domain [IPR010674]", "Nucleolar GTP-binding protein 2, N-terminal domain [IPR012971]", "Nucleolar complex-associated protein 3, N-terminal [IPR011501]", "Nucleolar pre-ribosomal-associated protein 1, C-terminal domain [IPR032436]", "Nucleolar pre-ribosomal-associated protein 1, N-terminal [IPR021714]", "Nucleolar protein 7, C-terminal [IPR012579]", "Nucleolar protein 8, RNA recognition motif [IPR034138]", "Nucleolin, RNA recognition motif 1 [IPR034230]", "Nucleolin, RNA recognition motif 2 [IPR034233]", "Nucleolin, RNA recognition motif 3 [IPR034234]", "Nucleolin, RNA recognition motif 4 [IPR034235]", "Nucleophosmin, C-terminal [IPR032569]", "Nucleoplasmin core domain [IPR024057]", "Nucleoporin Nup153, N-terminal [IPR013913]", "Nucleoporin Nup188, N-terminal [IPR018864]", "Nucleoporin Nup54, alpha-helical domain [IPR025712]", "Nucleoporin, NSP1-like, C-terminal [IPR007758]", "Nucleoporin, Nup133/Nup155-like, C-terminal [IPR007187]", "Nucleoporin, Nup133/Nup155-like, N-terminal [IPR014908]", "Nucleoprotein TPR/MLP1 [IPR012929]", "Nucleoredoxin, redox inactive TRX-like domain b' [IPR041861]", "Nucleoside diphosphate kinase-like domain [IPR034907]", "Nucleoside phosphorylase domain [IPR000845]", "Nucleotide exchange factor Fes1 [IPR013918]", "Nucleotidyl transferase domain [IPR005835]", "NudC N-terminal domain [IPR025934]", "NudC domain-containing protein 2, p23 domain [IPR037902]", "NudC domain-containing protein 3, p23 domain [IPR037905]", "NuoE domain [IPR042128]", "Nup358/RanBP2 E3 ligase domain [IPR022011]", "Nup54, C-terminal interacting domain [IPR040985]", "NusG, N-terminal [IPR006645]", "O-GlcNAc transferase, C-terminal [IPR029489]", "OB-fold nucleic acid binding domain, AA-tRNA synthetase-type [IPR004365]", "OBG-type guanine nucleotide-binding (G) domain [IPR031167]", "OCRE domain [IPR041591]", "OCRL1, PH domain [IPR037787]", "OCRL1/INPP5B, INPP5c domain [IPR037793]", "OTU domain [IPR003323]", "Occludin homology domain [IPR010844]", "Orc1-like, AAA ATPase domain [IPR041664]", "Origin recognition complex subunit 3, N-terminal [IPR045667]", "Origin recognition complex subunit 3, insertion domain [IPR045663]", "Origin recognition complex subunit 3, winged helix C-terminal [IPR040855]", "Orotate phosphoribosyl transferase domain [IPR004467]", "Orotidine 5'-phosphate decarboxylase domain [IPR001754]", "Ovarian carcinoma immunoreactive antigen domain [IPR009764]", "Oxidoreductase FAD/NAD(P)-binding [IPR001433]", "Oxidoreductase, N-terminal domain [IPR041694]", "Oxoglutarate/iron-dependent dioxygenase [IPR005123]", "P-type ATPase, haloacid dehalogenase domain [IPR044492]", "P-type trefoil domain [IPR000519]", "PA domain [IPR003137]", "PABP, RNA recognition motif 2 [IPR045305]", "PACSIN1/PACSIN2, SH3 domain [IPR035743]", "PACSIN2, F-BAR domain [IPR037453]", "PADR1 domain [IPR012982]", "PAP/25A-associated [IPR002058]", "PARN, R3H domain [IPR034042]", "PAZ domain [IPR003100]", "PB1 domain [IPR000270]", "PDIP3, RNA recognition motif [IPR034784]", "PDZ domain 6 [IPR041489]", "PDZ domain [IPR001478]", "PDZ-associated domain of NMDA receptors [IPR019583]", "PET domain [IPR010442]", "PET testin [IPR033724]", "PH-BEACH domain [IPR023362]", "PHR [IPR012983]", "PI3K p85 subunit, C-terminal SH2 domain [IPR035020]", "PI3K p85 subunit, N-terminal SH2 domain [IPR035022]", "PI3K regulatory subunit p85-related , inter-SH2 domain [IPR032498]", "PI3K-C2-alpha, catalytic domain [IPR037705]", "PI4-kinase, N-terminal [IPR045495]", "PIH1, N-terminal [IPR012981]", "PIH1D1/2/3, CS-like domain [IPR041442]", "PIK-related kinase [IPR014009]", "PIK-related kinase, FAT [IPR003151]", "PIN domain [IPR002716]", "PITH domain [IPR010400]", "PKD domain [IPR000601]", "PKD/Chitinase domain [IPR022409]", "PKHA4-7, PH domain [IPR040392]", "PLAA family ubiquitin binding domain [IPR015155]", "PLC-gamma, C-terminal SH2 domain [IPR035023]", "PLC-gamma, N-terminal SH2 domain [IPR035024]", "PLD-like domain [IPR032803]", "PNK, FHA domain [IPR041388]", "POLO box domain [IPR000959]", "POPLD domain [IPR012590]", "POTRA domain [IPR034746]", "PP2B, metallophosphatase domain [IPR041751]", "PP5, C-terminal metallophosphatase domain [IPR041753]", "PPIL4-like, cyclophilin domain [IPR035538]", "PPM-type phosphatase domain [IPR001932]", "PPP domain [IPR013235]", "PRKAA1, UBA-like autoinhibitory domain [IPR028797]", "PRKAA2, UBA-like autoinhibitory domain [IPR028783]", "PRMT5 arginine-N-methyltransferase [IPR035075]", "PRMT5, TIM barrel domain [IPR035247]", "PRMT5, oligomerisation domain [IPR035248]", "PRO8NT domain [IPR012591]", "PROCN domain [IPR012592]", "PROCT domain [IPR012984]", "PRP1 splicing factor, N-terminal [IPR010491]", "PRP8 domain IV core [IPR021983]", "PSF, NOPS domain [IPR034526]", "PSF, RNA recognition motif 1 [IPR034525]", "PSI domain [IPR016201]", "PSP, proline-rich [IPR006568]", "PSP1, RNA recognition motif 1 [IPR034522]", "PSP1, RNA recognition motif 2 [IPR034523]", "PTB/PI domain [IPR006020]", "PTBP1, RNA recognition motif 1 [IPR035000]", "PTBP1, RNA recognition motif 2-like [IPR021790]", "PTBP1, RNA recognition motif 3 [IPR035001]", "PTBP2, RNA recognition motif 1 [IPR035002]", "PTBP2, RNA recognition motif 3 [IPR034799]", "PTBP2, RNA recognition motif 4 [IPR034800]", "PUA domain [IPR002478]", "PUF60, RNA recognition motif 1 [IPR034209]", "PUF60, RNA recognition motif 2 [IPR034211]", "PUF60, RNA recognition motif 3 [IPR034212]", "PUL domain [IPR013535]", "PWI domain [IPR002483]", "PWWP domain [IPR000313]", "Paf1 complex subunit Cdc73, N-terminal domain [IPR032041]", "Palladin, C-terminal immunoglobulin-like domain [IPR033017]", "Pancreatic trypsin inhibitor Kunitz domain [IPR002223]", "Par3/HAL, N-terminal [IPR021922]", "Patatin-like phospholipase domain [IPR002641]", "Patatin-like phospholipase domain containing protein 8-like [IPR045217]", "Pentacotripeptide-repeat region of PRORP [IPR033443]", "Pep3/Vps18/deep orange [IPR007810]", "Peptidase C12, C-terminal domain [IPR041507]", "Peptidase C12, ubiquitin carboxyl-terminal hydrolase [IPR001578]", "Peptidase C14, p20 domain [IPR001309]", "Peptidase C19, ubiquitin carboxyl-terminal hydrolase [IPR001394]", "Peptidase C19, ubiquitin-specific peptidase, DUSP domain [IPR006615]", "Peptidase C1A, papain C-terminal [IPR000668]", "Peptidase C2, calpain, catalytic domain [IPR001300]", "Peptidase C2, calpain, domain III [IPR022683]", "Peptidase C2, calpain, large subunit, domain III [IPR022682]", "Peptidase M1, leukotriene A4 hydrolase/aminopeptidase C-terminal [IPR015211]", "Peptidase M1, membrane alanine aminopeptidase [IPR014782]", "Peptidase M13, C-terminal domain [IPR018497]", "Peptidase M13, N-terminal domain [IPR008753]", "Peptidase M14, carboxypeptidase A [IPR000834]", "Peptidase M16, C-terminal [IPR007863]", "Peptidase M16, N-terminal [IPR011765]", "Peptidase M16, middle/third domain [IPR032632]", "Peptidase M16C associated [IPR013578]", "Peptidase M17, leucyl aminopeptidase, C-terminal [IPR000819]", "Peptidase M17, leucyl aminopeptidase, N-terminal [IPR008283]", "Peptidase M20, dimerisation domain [IPR011650]", "Peptidase M24 [IPR000994]", "Peptidase M24, C-terminal domain [IPR032416]", "Peptidase M28 [IPR007484]", "Peptidase M3A/M3B catalytic domain [IPR001567]", "Peptidase M41 [IPR000642]", "Peptidase M41, FtsH extracellular [IPR011546]", "Peptidase M48 [IPR001915]", "Peptidase S16, Lon proteolytic domain [IPR008269]", "Peptidase S24/S26A/S26B/S26C [IPR015927]", "Peptidase S26 [IPR019533]", "Peptidase S53, activation domain [IPR015366]", "Peptidase S54, rhomboid domain [IPR022764]", "Peptidase S59, nucleoporin [IPR007230]", "Peptidase S8/S53 domain [IPR000209]", "Peptidase S8A, tripeptidyl peptidase II [IPR022229]", "Peptidase S9, prolyl oligopeptidase, catalytic domain [IPR001375]", "Peptidase S9A, N-terminal domain [IPR023302]", "Peptidase family M60 domain [IPR031161]", "Peptide chain release factor class I [IPR000352]", "Peptidyl-prolyl cis-trans isomerase E, RNA recognition motif [IPR034168]", "Peptidyl-prolyl cis-trans isomerase, PpiC-type [IPR000297]", "Pericentrin/AKAP-450 centrosomal targeting domain [IPR019528]", "Pericentriolar material 1 protein, C-terminal [IPR031446]", "Peripheral subunit-binding domain [IPR004167]", "Peroxiredoxin, C-terminal [IPR019479]", "Peroxisome membrane anchor protein Pex14p, N-terminal [IPR006785]", "PheRS DNA binding domain 2 [IPR040586]", "PheRS, DNA binding domain 1 [IPR040724]", "PheRS, DNA binding domain 3 [IPR040725]", "Phenylacetic acid degradation-related domain [IPR003736]", "Phenylalanine--tRNA ligase beta subunit, B1 domain [IPR040659]", "Phenylalanyl tRNA synthetase beta chain, core domain [IPR041616]", "Phenylalanyl-tRNA synthetase [IPR002319]", "Phosducin, thioredoxin-like domain [IPR024253]", "Phosphatidic acid phosphatase type 2/haloperoxidase [IPR000326]", "Phosphatidylinositol 3-/4-kinase, catalytic domain [IPR000403]", "Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain [IPR000341]", "Phosphatidylinositol 3-kinase regulatory subunit beta, SH3 domain [IPR035586]", "Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha, PX domain [IPR042133]", "Phosphatidylinositol-4-phosphate 5-kinase, core [IPR002498]", "Phosphatidylinositol-specific phospholipase C, X domain [IPR000909]", "Phosphoadenosine phosphosulphate reductase [IPR002500]", "Phosphofructokinase domain [IPR000023]", "Phosphoglucose isomerase, SIS domain 1 [IPR035476]", "Phosphoglucose isomerase, SIS domain 2 [IPR035482]", "Phosphoinositide 3-kinase, accessory (PIK) domain [IPR001263]", "Phospholipase C, phosphatidylinositol-specific, Y domain [IPR001711]", "Phospholipase D-like domain [IPR025202]", "Phospholipase D/Transphosphatidylase [IPR001736]", "Phospholipase/carboxylesterase/thioesterase [IPR003140]", "Phospholipid/glycerol acyltransferase [IPR002123]", "Phosphopantetheine binding ACP domain [IPR009081]", "Phosphoribosylformylglycinamidine synthase, N-terminal [IPR040707]", "Phosphoribosylformylglycinamidine synthase, linker domain [IPR041609]", "Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain [IPR020561]", "Phosphoribosylglycinamide synthetase, C-domain [IPR020560]", "Phosphoribosylglycinamide synthetase, N-terminal [IPR020562]", "Phosphoribosyltransferase domain [IPR000836]", "Phosphoribulokinase/uridine kinase [IPR006083]", "Phosphorylase b kinase regulatory subunit alpha/beta, C-terminal domain [IPR045583]", "Phosphotyrosine protein phosphatase I [IPR023485]", "Phox homology [IPR001683]", "Phox-associated domain [IPR003114]", "Pinin/SDK [IPR006787]", "Pinin/SDK/MemA protein [IPR006786]", "Pirin, C-terminal domain [IPR008778]", "Pirin, N-terminal domain [IPR003829]", "Plasma membrane calcium transporting P-type ATPase, C-terminal [IPR022141]", "Pleckstrin homology domain 8 [IPR041680]", "Pleckstrin homology domain 9 [IPR041681]", "Pleckstrin homology domain [IPR001849]", "Pleckstrin homology domain, spectrin-type [IPR001605]", "Plectin/S10, N-terminal [IPR005326]", "Plexin, TIG domain 1 [IPR041019]", "Plexin, cytoplasmic RasGAP domain [IPR013548]", "Polo-like kinase 1, catalytic domain [IPR033702]", "Poly(A) polymerase, RNA-binding domain [IPR007010]", "Poly(A) polymerase, central domain [IPR007012]", "Poly(A)-specific ribonuclease, RNA-binding [IPR014789]", "Poly(ADP-ribose) polymerase, catalytic domain [IPR012317]", "Poly(ADP-ribose) polymerase, regulatory domain [IPR004102]", "Polyadenylate-binding protein/Hyperplastic disc protein [IPR002004]", "Polyamine biosynthesis domain [IPR030374]", "Polycomb group protein, RNA binding region [IPR033763]", "Polycomb protein, VEFS-Box [IPR019135]", "Polyketide synthase, C-terminal extension [IPR032821]", "Polyketide synthase, beta-ketoacyl synthase domain [IPR020841]", "Polyketide synthase, dehydratase domain [IPR020807]", "Polyketide synthase, enoylreductase domain [IPR020843]", "Polyketide synthase, ketoreductase domain [IPR013968]", "Polyketide synthase, phosphopantetheine-binding domain [IPR020806]", "Polymerase, nucleotidyl transferase domain [IPR002934]", "Polynucleotide 3'-phosphatase [IPR006551]", "Polypyrimidine tract-binding protein1/2/3, RNA recognition motif 2 [IPR034798]", "Polyribonucleotide 5'-hydroxyl-kinase Clp1, P-loop domain [IPR032319]", "Polyribonucleotide nucleotidyltransferase, RNA-binding domain [IPR015848]", "Polysaccharide biosynthesis domain [IPR021148]", "Pop1, N-terminal [IPR009723]", "Porphobilinogen deaminase, C-terminal [IPR022418]", "Porphobilinogen deaminase, N-terminal [IPR022417]", "Possible tRNA binding domain [IPR027992]", "Post-SET domain [IPR003616]", "Potassium channel tetramerisation-type BTB domain [IPR003131]", "Potentiating neddylation domain [IPR005176]", "Pre-PUA domain [IPR041366]", "Pre-SET domain [IPR007728]", "Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term [IPR021718]", "Pre-mRNA polyadenylation factor Fip1 domain [IPR007854]", "Pre-mRNA processing factor 4 (PRP4)-like [IPR014906]", "Pre-mRNA splicing factor component Cdc5p/Cef1, C-terminal [IPR021786]", "Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding [IPR019581]", "Pre-mRNA-processing-splicing factor 8, U6-snRNA-binding [IPR019580]", "Pre-mRNA-splicing factor 19 [IPR013915]", "Pre-mRNA-splicing factor 3 [IPR013881]", "Pre-rRNA-processing protein Ipi1, N-terminal [IPR024679]", "Pre-rRNA-processing protein RIX1, N-terminal [IPR012583]", "Predicted HAD-superfamily phosphatase, subfamily IA/Epoxide hydrolase, N-terminal [IPR011945]", "Prenylcysteine lyase [IPR010795]", "Probable RNA-binding protein 19, RNA recognition motif 1 [IPR034418]", "Probable RNA-binding protein 19, RNA recognition motif 2 [IPR034417]", "Probable RNA-binding protein 19, RNA recognition motif 3 [IPR034419]", "Probable RNA-binding protein 19, RNA recognition motif 4 [IPR034420]", "Probable RNA-binding protein 19, RNA recognition motif 5 [IPR034423]", "Probable RNA-binding protein 19, RNA recognition motif 6 [IPR034421]", "Proliferating cell nuclear antigen, PCNA, C-terminal [IPR022649]", "Proliferating cell nuclear antigen, PCNA, N-terminal [IPR022648]", "Proline-tRNA ligase, class II, C-terminal [IPR016061]", "Prolyl 4-hydroxylase alpha subunit, Fe(2+) 2OG dioxygenase domain [IPR044862]", "Prolyl 4-hydroxylase alpha-subunit, N-terminal [IPR013547]", "Prolyl 4-hydroxylase, alpha subunit [IPR006620]", "Prolyl-tRNA synthetase, catalytic domain [IPR033721]", "Propionyl-coenzyme A carboxylase, BT domain [IPR041265]", "Prostaglandin E synthase 2, C-terminal [IPR034335]", "Proteasomal ATPase OB C-terminal domain [IPR032501]", "Proteasome activator Blm10, mid region [IPR032430]", "Proteasome activator PA28, C-terminal domain [IPR003186]", "Proteasome activator PA28, N-terminal domain [IPR003185]", "Proteasome activator complex subunit 4 C-terminal domain [IPR021843]", "Proteasome alpha-subunit, N-terminal domain [IPR000426]", "Proteasome beta subunit, C-terminal [IPR024689]", "Proteasome component (PCI) domain [IPR000717]", "Protein HGH1 C-terminal [IPR007206]", "Protein HGH1 N-terminal [IPR007205]", "Protein Kinase B beta, catalytic domain [IPR034677]", "Protein Kinase B, pleckstrin homology domain [IPR039026]", "Protein O-mannosyl-transferase TMTC, DUF1736 [IPR013618]", "Protein RED, C-terminal [IPR012492]", "Protein Smaug, SAM domain [IPR037634]", "Protein disulfide-isomerase A3, first redox inactive TRX-like domain b [IPR041868]", "Protein disulfide-isomerase A4, TRX-like domain b [IPR041866]", "Protein furry, C-terminal [IPR045842]", "Protein kinase C-like, phorbol ester/diacylglycerol-binding domain [IPR002219]", "Protein kinase domain [IPR000719]", "Protein kinase, C-terminal [IPR017892]", "Protein of unknown function DUF3504 [IPR021893]", "Protein of unknown function DUF3715 [IPR022188]", "Protein phosphatase 1 binding domain [IPR029334]", "Protein polybromo-1, Bromodomain 5 [IPR037968]", "Protein quaking, putative nuclear localisation signal [IPR032367]", "Protein-only RNase P, C-terminal [IPR031595]", "Protein-tyrosine phosphatase, catalytic [IPR003595]", "Prp31 C-terminal [IPR019175]", "Pseudouridine synthase I, TruA, alpha/beta domain [IPR020097]", "Pseudouridine synthase II, N-terminal [IPR002501]", "Pseudouridine synthase, RsuA/RluA-like [IPR006145]", "Pseudouridine synthase, TruD, insertion domain [IPR011760]", "Pterin-binding domain [IPR000489]", "Pumilio homology domain [IPR033133]", "PurE domain [IPR000031]", "PurM-like, C-terminal domain [IPR010918]", "PurM-like, N-terminal domain [IPR016188]", "Putative 5-3 exonuclease [IPR004859]", "Putative RNA methylase domain [IPR000241]", "Putative RNA-binding protein 27, RNA recognition motif [IPR034451]", "Putative RNA-binding protein 47, RNA recognition motif 2 [IPR034440]", "Putative RNA-binding protein 47, RNA recognition motif 3 [IPR034445]", "Putative WW-binding domain and destruction box [IPR033461]", "Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain [IPR004099]", "Pyrroline-5-carboxylate reductase, catalytic, N-terminal [IPR028939]", "Pyrroline-5-carboxylate reductase, dimerisation domain [IPR029036]", "Pyruvate carboxyltransferase [IPR000891]", "Pyruvate kinase, C-terminal [IPR015795]", "Pyruvate kinase, barrel [IPR015793]", "R3H domain [IPR001374]", "RABX5, catalytic core helical domain [IPR041545]", "RAD23A/RAD23B, UBA1 domain [IPR041811]", "RAD50, zinc hook [IPR013134]", "RAP domain [IPR013584]", "RAWUL domain [IPR032443]", "RBM10, OCRE domain [IPR035618]", "RBM12, RNA recognition motif 1 [IPR034591]", "RBM12, RNA recognition motif 2 [IPR034594]", "RBM12, RNA recognition motif 3 [IPR034855]", "RBM12, RNA recognition motif 4 [IPR034856]", "RBM12, RNA recognition motif 5 [IPR034854]", "RBM12B, RNA recognition motif 2 [IPR034588]", "RBM12B, RNA recognition motif 3 [IPR034858]", "RBM14, RNA recognition motif 1 [IPR034506]", "RBM14, RNA recognition motif 2 [IPR034507]", "RBM1CTR [IPR012604]", "RBM25, RNA recognition motif [IPR034268]", "RBM26, RNA recognition motif 1 [IPR034859]", "RBM26-like, RNA recognition motif 2 [IPR039511]", "RBM3/CIRBP, RNA recognition motif [IPR034278]", "RBM34, RNA recognition motif 1 [IPR034220]", "RBM34, RNA recognition motif 2 [IPR034221]", "RBM4, RNA recognition motif 1 [IPR034897]", "RBM4, RNA recognition motif 2 [IPR034898]", "RBM45, RNA recognition motif 1 [IPR034203]", "RBM45, RNA recognition motif 2 [IPR034206]", "RBM45, RNA recognition motif 3 [IPR034207]", "RBM45, RNA recognition motif 4 [IPR034208]", "RBM6, OCRE domain [IPR035617]", "RBM6, RNA recognition motif 1 [IPR034123]", "RBM6, RNA recognition motif 2 [IPR034125]", "RBM8, RNA recognition motif [IPR033744]", "RBP-J/Cbf11/Cbf12, DNA binding [IPR015351]", "RBP-Jkappa, IPT domain [IPR038007]", "RED-like, N-terminal [IPR012916]", "REKLES domain [IPR023334]", "RGS domain [IPR016137]", "RH1 domain [IPR034743]", "RH2 domain [IPR034744]", "RHIM domain [IPR025735]", "RING finger and SPRY domain-containing protein 1, SPRY domain [IPR035774]", "RING-type zinc-finger, LisH dimerisation motif [IPR027370]", "RIP1, Death domain [IPR037934]", "RL domain [IPR041252]", "RLI, domain 1 [IPR034348]", "RNA 3'-terminal phosphate cyclase domain [IPR023797]", "RNA 3'-terminal phosphate cyclase, insert domain [IPR013791]", "RNA binding activity-knot of a chromodomain [IPR025995]", "RNA exonuclease 4, DEDDh 3'-5' exonuclease domain [IPR037431]", "RNA helicase UPF1, 1B domain [IPR040812]", "RNA helicase UPF1, Cys/His rich zinc-binding domain [IPR018999]", "RNA helicase, DEAD-box type, Q motif [IPR014014]", "RNA methyltransferase bin3, C-terminal [IPR010675]", "RNA polymerase II elongation factor ELL, N-terminal [IPR019464]", "RNA polymerase II-associated protein 1, C-terminal [IPR013929]", "RNA polymerase II-associated protein 1, N-terminal [IPR013930]", "RNA polymerase III Rpc82, C -terminal [IPR008806]", "RNA polymerase III subunit RPC82-related, helix-turn-helix [IPR013197]", "RNA polymerase Rpb1, domain 1 [IPR007080]", "RNA polymerase Rpb1, domain 3 [IPR007066]", "RNA polymerase Rpb1, domain 4 [IPR007083]", "RNA polymerase Rpb1, domain 5 [IPR007081]", "RNA polymerase Rpb1, domain 6 [IPR007075]", "RNA polymerase Rpb1, domain 7 [IPR007073]", "RNA polymerase Rpb2, domain 2 [IPR007642]", "RNA polymerase Rpb2, domain 3 [IPR007645]", "RNA polymerase Rpb2, domain 4 [IPR007646]", "RNA polymerase Rpb2, domain 5 [IPR007647]", "RNA polymerase Rpb2, domain 7 [IPR007641]", "RNA polymerase Rpb4/RPC9, core [IPR006590]", "RNA polymerase Rpb7-like , N-terminal [IPR005576]", "RNA polymerase, N-terminal [IPR006592]", "RNA polymerase, Rpb5, N-terminal [IPR005571]", "RNA polymerase, alpha subunit [IPR000722]", "RNA polymerase, beta subunit, protrusion [IPR007644]", "RNA polymerase, subunit H/Rpb5 C-terminal [IPR000783]", "RNA recognition motif domain [IPR000504]", "RNA recognition motif domain, eukaryote [IPR003954]", "RNA recognition motif, spliceosomal PrP8 [IPR019582]", "RNA-binding S4 domain [IPR002942]", "RNA-binding domain, S1 [IPR022967]", "RNA-binding protein 10, RNA recognition motif 2 [IPR034992]", "RNA-binding protein 5, RNA recognition motif 1 [IPR034991]", "RNA-binding protein 5, RNA recognition motif 2 [IPR034993]", "RNA-binding protein Musashi homologue, RNA recognition motif 1 [IPR034130]", "RNA-binding protein Musashi homologue, RNA recognition motif 2 [IPR034126]", "RNA-polymerase II-associated protein 3-like, C-terminal domain [IPR025986]", "RNA-recognition motif (RRM) Nup35-type domain [IPR007846]", "RNPS1, RNA recognition motif [IPR034201]", "RNase L inhibitor RLI-like, possible metal-binding domain [IPR007209]", "ROCK, Rho binding domain [IPR015008]", "ROK, N-terminal [IPR012987]", "RPN1, N-terminal [IPR040892]", "RPN13, DEUBAD domain [IPR032368]", "RQC domain [IPR018982]", "RUN domain [IPR004012]", "RWD domain [IPR006575]", "Rab geranylgeranyltransferase, alpha subunit, insert-domain [IPR009087]", "Rab-GTPase-TBC domain [IPR000195]", "Rab-binding domain FIP-RBD [IPR019018]", "Rab3-GAP regulatory subunit, N-terminal [IPR032839]", "Rab3GAP catalytic subunit, C-terminal [IPR045698]", "Rab3GAP catalytic subunit, conserved domain [IPR026147]", "Rab3GAP regulatory subunit, C-terminal [IPR029257]", "Rad18, zinc finger UBZ4-type [IPR006642]", "Rad21/Rec8-like protein, C-terminal, eukaryotic [IPR006909]", "Rad21/Rec8-like protein, N-terminal [IPR006910]", "Rad50, ATP-binding cassette domain [IPR045171]", "Rad50/SbcC-type AAA domain [IPR038729]", "Rad60/SUMO-like domain [IPR022617]", "Radical SAM [IPR007197]", "Radical SAM, C-terminal extension [IPR032432]", "Raly, RNA recognition motif [IPR034502]", "Ran binding domain [IPR000156]", "Ran binding protein 9/10, SPRY domain [IPR035782]", "Ran-GTPase activating protein 1, C-terminal [IPR009109]", "Ran-specific GTPase-activating protein 1, Ran-binding domain [IPR045256]", "Rap1 Myb domain [IPR015010]", "Raptor, N-terminal CASPase-like domain [IPR029347]", "Ras GTPase-activating domain [IPR001936]", "Ras guanine-nucleotide exchange factors catalytic domain [IPR001895]", "Ras-associating (RA) domain [IPR000159]", "Ras-like guanine nucleotide exchange factor, N-terminal [IPR000651]", "RasGAP protein, C-terminal [IPR000593]", "RecF/RecN/SMC, N-terminal [IPR003395]", "Redoxin [IPR013740]", "Replication factor A, C-terminal [IPR013955]", "Replication factor C, C-terminal [IPR013748]", "Replication factor Mcm10, C-terminal [IPR015411]", "Replication factor-A protein 1, N-terminal [IPR007199]", "Replication protein A, C-terminal [IPR014892]", "Replication protein A, OB domain [IPR031657]", "Replication termination factor 2, RING-finger [IPR027799]", "Reticulon [IPR003388]", "Rho GTPase-activating protein domain [IPR000198]", "Rho GTPase-binding/formin homology 3 (GBD/FH3) domain [IPR014768]", "Rho-associated protein kinase 1, HR1 [IPR037310]", "Rho-associated protein kinase 2, HR1 domain [IPR037311]", "Rhodanese-like domain [IPR001763]", "Ribonuclease H1, N-terminal [IPR011320]", "Ribonuclease HII/HIII domain [IPR024567]", "Ribonuclease II/R [IPR001900]", "Ribonuclease III domain [IPR000999]", "Ribonuclease, PIN domain [IPR033411]", "Ribonucleoprotein PTB-binding 1, RNA recognition motif 1 [IPR034633]", "Ribonucleotide reductase large subunit, C-terminal [IPR000788]", "Ribonucleotide reductase large subunit, N-terminal [IPR013509]", "Ribonucleotide reductase, class I , alpha subunit [IPR013346]", "Ribose-phosphate pyrophosphokinase, N-terminal domain [IPR029099]", "Ribosomal L28e/Mak16 [IPR029004]", "Ribosomal Protein L6, KOW domain [IPR041997]", "Ribosomal Proteins L2, RNA binding domain [IPR022666]", "Ribosomal RNA adenine methylase transferase, N-terminal [IPR020598]", "Ribosomal RNA methyltransferase FtsJ domain [IPR002877]", "Ribosomal RNA methyltransferase Spb1, domain of unknown function DUF3381 [IPR024576]", "Ribosomal RNA methyltransferase, Spb1, C-terminal [IPR012920]", "Ribosomal RNA small subunit methyltransferase F, N-terminal [IPR031341]", "Ribosomal RNA-processing protein 14/surfeit locus protein 6, C-terminal domain [IPR029190]", "Ribosomal S6 kinase, N-terminal catalytic domain [IPR041906]", "Ribosomal protein 50S-L18Ae/60S-L20/60S-L18A [IPR023573]", "Ribosomal protein L10e/L16 [IPR016180]", "Ribosomal protein L11, C-terminal [IPR020783]", "Ribosomal protein L11, N-terminal [IPR020784]", "Ribosomal protein L14, KOW motif [IPR041985]", "Ribosomal protein L14e domain [IPR002784]", "Ribosomal protein L18e/L15P [IPR021131]", "Ribosomal protein L19, eukaryotic [IPR033935]", "Ribosomal protein L19/L19e [IPR000196]", "Ribosomal protein L2, C-terminal [IPR022669]", "Ribosomal protein L23/L25, N-terminal [IPR005633]", "Ribosomal protein L26/L24, KOW domain [IPR041988]", "Ribosomal protein L30, N-terminal [IPR012988]", "Ribosomal protein L30, ferredoxin-like fold domain [IPR016082]", "Ribosomal protein L46, N-terminal [IPR021757]", "Ribosomal protein L5 eukaryotic, C-terminal [IPR025607]", "Ribosomal protein L5, C-terminal [IPR031309]", "Ribosomal protein L5, N-terminal [IPR031310]", "Ribosomal protein L6, N-terminal [IPR005568]", "Ribosomal protein L6, alpha-beta domain [IPR020040]", "Ribosomal protein L7, eukaryotic/archaeal [IPR035808]", "Ribosomal protein L7/L12, C-terminal [IPR013823]", "Ribosomal protein L7/L12, oligomerisation [IPR008932]", "Ribosomal protein L7Ae/L30e/S12e/Gadd45 [IPR004038]", "Ribosomal protein L9, N-terminal [IPR020070]", "Ribosomal protein S10 domain [IPR027486]", "Ribosomal protein S13/S15, N-terminal [IPR012606]", "Ribosomal protein S23/S25, mitochondrial [IPR023611]", "Ribosomal protein S24/S35, mitochondrial, conserved domain [IPR019349]", "Ribosomal protein S3, C-terminal [IPR001351]", "Ribosomal protein S4, KOW domain [IPR041982]", "Ribosomal protein S4/S9, N-terminal [IPR001912]", "Ribosomal protein S4e, N-terminal [IPR013843]", "Ribosomal protein S4e, central region [IPR013845]", "Ribosomal protein S5, C-terminal [IPR005324]", "Ribosomal protein S5, N-terminal [IPR013810]", "Ribosomal protein S6 kinase alpha-3, C-terminal catalytic domain [IPR041905]", "Ribosomal protein S7 domain [IPR023798]", "Ribosomal protein/NADH dehydrogenase domain [IPR007741]", "Ribosome biogenesis protein BMS1/TSR1, C-terminal [IPR007034]", "Ribosome biogenesis protein Bms1, N-terminal [IPR037875]", "Ribosome maturation protein Sdo1/SBDS, C-terminal [IPR018978]", "Ribosome maturation protein Sdo1/SBDS, N-terminal [IPR019783]", "Ribosome receptor lysine/proline rich [IPR007794]", "Ribosome recycling factor domain [IPR023584]", "Ribosome-associated complex head domain [IPR032003]", "Ricin B, lectin domain [IPR000772]", "Rieske iron-sulphur protein, C-terminal [IPR005805]", "Right handed beta helix domain [IPR039448]", "RmlD-like substrate binding domain [IPR029903]", "Rpn11/EIF3F, C-terminal [IPR024969]", "Rpn13/ADRM1, Pru domain [IPR044868]", "RrmJ-type ribose 2-O-methyltransferase domain [IPR025816]", "Rrp40, S1 domain [IPR037319]", "Rrp44-like cold shock domain [IPR033771]", "Rubisco LSMT, substrate-binding domain [IPR015353]", "RuvB-like, AAA-lid domain [IPR041048]", "S-adenosyl-L-homocysteine hydrolase, NAD binding domain [IPR015878]", "S-adenosylmethionine synthetase, C-terminal [IPR022630]", "S-adenosylmethionine synthetase, N-terminal [IPR022628]", "S-adenosylmethionine synthetase, central domain [IPR022629]", "S1 domain [IPR003029]", "S1-like RNA binding domain [IPR025223]", "S100/CaBP-9k-type, calcium binding, subdomain [IPR013787]", "SAB domain [IPR007477]", "SAC domain [IPR002013]", "SAF domain [IPR013974]", "SAICAR synthetase/ADE2, N-terminal [IPR028923]", "SAM domain [IPR041418]", "SAM-dependent methyltransferase RsmB/NOP2-type [IPR001678]", "SANT domain [IPR017884]", "SANT/Myb domain [IPR001005]", "SAP domain [IPR003034]", "SARAH domain [IPR011524]", "SART3, RNA recognition motif 1 [IPR034217]", "SART3, RNA recognition motif 2 [IPR034218]", "SCAF4, RNA recognition motif [IPR034369]", "SCP2 sterol-binding domain [IPR003033]", "SDA1 domain [IPR007949]", "SEC23-interacting protein, SAM domain [IPR037603]", "SERRATE/Ars2 , C-terminal [IPR007042]", "SERRATE/Ars2, N-terminal [IPR021933]", "SET domain [IPR001214]", "SETD2/Set2, SET domain [IPR044437]", "SETD3, SET domain [IPR044428]", "SF3A2 domain [IPR031781]", "SF3A3 domain [IPR031774]", "SF3B4, RNA recognition motif 1 [IPR034158]", "SF3B4, RNA recognition motif 2 [IPR034159]", "SF3B6, RNA recognition motif [IPR034150]", "SGF29 tudor-like domain [IPR010750]", "SGNH hydrolase-type esterase domain [IPR013830]", "SGS domain [IPR007699]", "SGTA, homodimerisation domain [IPR032374]", "SH2 domain [IPR000980]", "SH3 domain [IPR001452]", "SH3-like domain, bacterial-type [IPR003646]", "SHARP, RNA recognition motif 1 [IPR034172]", "SHARP, RNA recognition motif 2 [IPR034173]", "SHARP, RNA recognition motif 3 [IPR034174]", "SHARP, RNA recognition motif 4 [IPR034175]", "SIS domain [IPR001347]", "SKI-interacting protein SKIP, SNW domain [IPR004015]", "SKP1 component, POZ domain [IPR016073]", "SKP1 component, dimerisation [IPR016072]", "SLC12A transporter, C-terminal [IPR018491]", "SLED domain [IPR021987]", "SLIDE domain [IPR015195]", "SLIRP, RNA recognition motif [IPR034152]", "SMARCA1, N-terminal [IPR044755]", "SMARCC, C-terminal [IPR032451]", "SMARCC, N-terminal [IPR032450]", "SMARCC, SWIRM-associated domain [IPR032448]", "SMCs flexible hinge [IPR010935]", "SMG1, PIKK catalytic domain [IPR039414]", "SNARE-complex protein Syntaxin-18, N-terminal [IPR019529]", "SNF2, N-terminal [IPR000330]", "SNX17, atypical FERM-like domain [IPR037836]", "SNX19, PX domain [IPR037909]", "SNX2, PX domain [IPR037918]", "SNX27, PX domain [IPR037833]", "SNX27, RA domain [IPR037835]", "SNX27, atypical FERM-like domain [IPR037827]", "SNX5, PX domain [IPR042135]", "SNX6, PX domain [IPR042136]", "SNX9, SH3 domain [IPR035558]", "SOCS box domain [IPR001496]", "SPF45, RNA recognition motif [IPR034653]", "SPIN90, SH3 domain [IPR035514]", "SPIN90/Ldb17, leucine-rich domain [IPR018556]", "SPRY domain [IPR003877]", "SPRY-associated [IPR006574]", "SR140, RNA recognition motif [IPR035009]", "SRA-YDG [IPR003105]", "SRCR domain [IPR001190]", "SRCR-like domain [IPR017448]", "SREK1, RNA recognition motif 2 [IPR034192]", "SRP9 domain [IPR039432]", "SRSF1, RNA recognition motif 1 [IPR034520]", "SRSF7, RNA recognition motif [IPR034651]", "SRSF9, RNA recognition motif 1 [IPR034503]", "SRSF9, RNA recognition motif 2 [IPR034995]", "SSRP1 domain [IPR024954]", "STAG [IPR013721]", "STAM1, SH3 domain [IPR035657]", "STAM2, SH3 domain [IPR035675]", "STAR protein, homodimerisation region [IPR032377]", "STARD11, START domain [IPR041952]", "START domain [IPR002913]", "STAT transcription factor, DNA-binding [IPR013801]", "STAT transcription factor, all-alpha domain [IPR013800]", "STAT transcription factor, protein interaction [IPR013799]", "STAT1, SH2 domain [IPR035859]", "STAT3, SH2 domain [IPR035855]", "STI1 domain [IPR041243]", "STRBP, first double-stranded RNA binding domain [IPR044472]", "SUI1 domain [IPR001950]", "SUMO-activating enzyme subunit 2, C-terminal domain [IPR032426]", "SUN coiled coil domain 2 [IPR040994]", "SUN domain [IPR012919]", "SUN domain-containing protein 1, N-terminal [IPR032680]", "SUZ-C domain [IPR024642]", "SWAP/Surp [IPR000061]", "SWI/SNF-like complex subunit BAF250, C-terminal [IPR033388]", "SWIB domain [IPR019835]", "SWIB/MDM2 domain [IPR003121]", "SWIRM domain [IPR007526]", "Saccharopine dehydrogenase, NADP binding domain [IPR005097]", "Saccharopine dehydrogenase-like, C-terminal [IPR032095]", "Sam68, tyrosine-rich domain [IPR032335]", "Saposin A-type domain [IPR003119]", "Saposin B type domain [IPR008139]", "Saposin B type, region 2 [IPR008138]", "Saposin-like type B, region 1 [IPR007856]", "Sas10 C-terminal domain [IPR018972]", "Scaffold protein Nfu/NifU, N-terminal [IPR014824]", "Schlafen group 3-like, DNA/RNA helicase domain [IPR018647]", "Schlafen, AlbA_2 domain [IPR007421]", "Sec16, central conserved domain [IPR024340]", "Sec23, C-terminal [IPR037550]", "Sec23/Sec24 beta-sandwich [IPR012990]", "Sec23/Sec24, helical domain [IPR006900]", "Sec23/Sec24, trunk domain [IPR006896]", "Sec24-like, trunk domain [IPR041742]", "Sec39 domain [IPR013244]", "Sec63 domain [IPR004179]", "Sec7 domain [IPR000904]", "Sec7, C-terminal [IPR015403]", "Second polo-box domain [IPR033695]", "Sedolisin domain [IPR030400]", "Sema domain [IPR001627]", "Senescence/spartin-associated, C-terminal [IPR009686]", "Sentrin-specific protease 3/5, conserved domain [IPR045577]", "Septin-type guanine nucleotide-binding (G) domain [IPR030379]", "Serine aminopeptidase, S33 [IPR022742]", "Serine hydroxymethyltransferase-like domain [IPR039429]", "Serine-tRNA ligase catalytic core domain [IPR033729]", "Serine-tRNA synthetase, type1, N-terminal [IPR015866]", "Serine-threonine protein phosphatase, N-terminal [IPR031675]", "Serine-threonine/tyrosine-protein kinase, catalytic domain [IPR001245]", "Serine/arginine-rich splicing factor SRSF4-like, RNA recognition motif 1 [IPR035585]", "Serine/threonine-protein PRP4, catalytic domain [IPR044092]", "Serine/threonine-protein kinase N, C2 domain [IPR037784]", "Serine/threonine-protein kinase N, first HR1 domain [IPR037313]", "Serine/threonine-protein kinase N1, second HR1 domain [IPR037317]", "Serine/threonine-protein kinase Nek9, catalytic domain [IPR042767]", "Serine/threonine-protein kinase OSR1/WNK, CCT domain [IPR024678]", "Serine/threonine-protein kinase SMG1, N-terminal [IPR035175]", "Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase [IPR006186]", "Serpin H1, serpin domain [IPR033830]", "Serpin domain [IPR023796]", "Set1A, RNA recognition motif [IPR034467]", "Set2 Rpb1 interacting domain [IPR013257]", "Siah interacting protein, N-terminal [IPR015120]", "Signal recognition particle SRP54, helical bundle [IPR013822]", "Signal recognition particle receptor, alpha subunit, N-terminal [IPR007222]", "Signal recognition particle subunit SRP68, RNA-binding domain [IPR034652]", "Signal recognition particle, SRP54 subunit, GTPase domain [IPR000897]", "Signal recognition particle, SRP54 subunit, M-domain [IPR004125]", "Signal recognition particle, SRP72 subunit, RNA-binding [IPR013699]", "Signal transducer and activation of transcription 1, TAZ2 binding domain, C-terminal [IPR022752]", "Signal transduction histidine kinase-related protein, C-terminal [IPR004358]", "Sin3, C-terminal [IPR031693]", "Sister chromatid cohesion C-terminal domain [IPR024986]", "Ski2, N-terminal domain [IPR040801]", "Sm-like protein Lsm4 [IPR034101]", "Small G protein signalling modulator 1/2, Rab-binding domain [IPR021935]", "Small GTP-binding protein domain [IPR005225]", "Small acidic protein-like domain [IPR028124]", "Small nuclear ribonucleoprotein D1 [IPR034102]", "Small-subunit processome, Utp12 [IPR007148]", "Small-subunit processome, Utp13 [IPR013934]", "Small-subunit processome, Utp21 [IPR007319]", "Smc1, ATP-binding cassette domain [IPR028468]", "Smc2, ATP-binding cassette domain [IPR027120]", "Snf2, ATP coupling domain [IPR029295]", "Snu114, GTP-binding domain [IPR044121]", "Sof1-like protein [IPR007287]", "Solute carrier family 3 member 2, N-terminal domain [IPR031984]", "Sortilin, C-terminal [IPR031777]", "Sortilin, N-terminal [IPR031778]", "Sorting Nexin 1, PX domain [IPR034901]", "Sorting nexin Vps5-like, C-terminal [IPR015404]", "Sorting nexin protein, WASP-binding domain [IPR019497]", "Sorting nexin, C-terminal [IPR013937]", "Sorting nexin, N-terminal [IPR005329]", "Sorting nexin-17/31, FERM domain [IPR040842]", "Sorting nexin-9, BAR domain [IPR037425]", "Sorting nexin-9, PX domain [IPR037426]", "Spen paralogue and orthologue SPOC, C-terminal [IPR012921]", "Spen paralogue/orthologue C-terminal, metazoa [IPR010912]", "Spermidine synthase, tetramerisation domain [IPR035246]", "Spermine synthase, N-terminal [IPR040900]", "Splicing factor 1, helix-hairpin domain [IPR032570]", "Splicing factor 3A subunit 1, conserved domain [IPR022030]", "Splicing factor 3A subunit 1, ubiquitin domain [IPR035563]", "Splicing factor 3B subunit 1 [IPR015016]", "Splicing factor ELAV/Hu, RNA recognition motif 1 [IPR034775]", "Splicing factor RBM39, linker [IPR029123]", "Splicing factor SF3a60 /Prp9 subunit, C-terminal [IPR024598]", "Splicing factor SF3a60 binding domain [IPR021966]", "Spp2/MOS2, G-patch domain [IPR026822]", "Spt5 C-terminal domain [IPR024945]", "Spt5 transcription elongation factor, N-terminal [IPR022581]", "Spt5, KOW domain repeat 1 [IPR041973]", "Spt5, KOW domain repeat 2 [IPR041975]", "Spt5, KOW domain repeat 3 [IPR041976]", "Spt5, KOW domain repeat 4 [IPR041977]", "Spt5, KOW domain repeat 5 [IPR041978]", "Spt5, KOW domain repeat 6 [IPR041980]", "Spt6 acidic, N-terminal domain [IPR028083]", "Spt6, SH2 domain [IPR035420]", "Spt6, SH2 domain, C terminus [IPR035018]", "Spt6, SH2 domain, N terminus [IPR035019]", "Squalene cyclase, C-terminal [IPR032696]", "Squalene cyclase, N-terminal [IPR032697]", "Squalene epoxidase [IPR013698]", "Srp40, C-terminal [IPR007718]", "Staphylococcal nuclease (SNase-like), OB-fold [IPR016071]", "Staufen 1, third double-stranded RNA binding domain [IPR044475]", "Staufen 2, first double-stranded RNA binding domain [IPR044476]", "Staufen 2, fourth double-stranded RNA binding domain [IPR044474]", "Staufen 2, second double-stranded RNA binding domain [IPR044464]", "Staufen 2, third double-stranded RNA binding domain [IPR044473]", "Staufen, C-terminal [IPR032478]", "Steadiness box (SB) domain [IPR017916]", "Sterile alpha motif domain [IPR001660]", "Sterol-sensing domain [IPR000731]", "Strawberry notch, AAA domain [IPR039187]", "Strawberry notch, helicase C domain [IPR026937]", "Striatin, N-terminal [IPR013258]", "Strictosidine synthase, conserved region [IPR018119]", "Stromalin conservative domain [IPR020839]", "Structural maintenance of chromosomes 3, ABC domain, eukaryotic [IPR041741]", "Structural maintenance of chromosomes 4, ABC domain, eukaryotic [IPR041738]", "Succinate dehydogenase/fumarate reductase N-terminal [IPR025192]", "Sulfatase, N-terminal [IPR000917]", "Sulfhydryl oxidase, Trx-like domain [IPR041269]", "Sulfhydryl oxidase, flavin adenine dinucleotide (FAD) binding domain [IPR040986]", "Sulphate adenylyltransferase [IPR002650]", "Sulphate adenylyltransferase catalytic domain [IPR024951]", "Suppressor of forked [IPR008847]", "Suppressor of white apricot, N-terminal domain [IPR019147]", "Survival motor neuron [IPR010304]", "Sushi/SCR/CCP domain [IPR000436]", "Suv3, C-terminal domain 1 [IPR041082]", "Suv3, DEXQ-box helicase domain [IPR044774]", "Suv3, N-terminal [IPR041453]", "Symplekin C-terminal [IPR022075]", "Symplekin/Pta1, N-terminal [IPR032460]", "Synaptic functional regulator FMRP, KH0 domain [IPR040472]", "Synaptotagmin, SMP domain [IPR039010]", "Synaptotagmin-like mitochondrial-lipid-binding domain [IPR031468]", "Syndetin, C-terminal [IPR019514]", "Syntaxin 6, N-terminal [IPR015260]", "Syntaxin, N-terminal domain [IPR006011]", "Syntaxin-8, SNARE domain [IPR041875]", "TAF6, C-terminal HEAT repeat domain [IPR011442]", "TAP C-terminal (TAP-C) domain [IPR005637]", "TAR DNA-binding protein 43, N-terminal [IPR041105]", "TATA box binding protein associated factor (TAF) [IPR004823]", "TATA-binding protein interacting (TIP20) [IPR013932]", "TBCE, ubiquitin-like (Ubl) domain [IPR044079]", "TCB1D9/TCB1D9B, PH-GRAM domain 1 [IPR036014]", "TCB1D9/TCB1D9B, PH-GRAM domain 2 [IPR036017]", "TFA2, Winged helix domain 2 [IPR040501]", "TFG box [IPR025768]", "TFG, PB1 domain [IPR034857]", "TFIIEalpha/SarR/Rpc3 HTH domain [IPR024550]", "TFIIH p62 subunit, N-terminal [IPR013876]", "TGS [IPR004095]", "THADA/TRM732, DUF2428 [IPR019442]", "THAP-type zinc finger [IPR006612]", "THIF-type NAD/FAD binding fold [IPR000594]", "THO complex subunit 2, N-terminal domain [IPR032302]", "THO complex, subunitTHOC2, C-terminal [IPR021418]", "THO complex, subunitTHOC2, N-terminal [IPR021726]", "THUMP domain [IPR004114]", "TIA-1, RNA recognition motif 2 [IPR034830]", "TIA-1, RNA recognition motif 3 [IPR034832]", "TIAR, RNA recognition motif 1 [IPR034492]", "TIAR, RNA recognition motif 2 [IPR034494]", "TIAR, RNA recognition motif 3 [IPR034496]", "TIF1-beta, RING finger, HC subclass [IPR042713]", "TIP49, P-loop domain [IPR010339]", "TNF receptor-associated factor 2, MATH domain [IPR037305]", "TNF receptor-associated factor, BIRC3 binding domain [IPR032070]", "TOG domain [IPR034085]", "TOPK, catalytic domain [IPR041989]", "TOPRIM domain [IPR006171]", "TPX2 central domain [IPR027330]", "TPX2, C-terminal [IPR027329]", "TRAM domain [IPR002792]", "TRAM/LAG1/CLN8 homology domain [IPR006634]", "TRASH domain [IPR011017]", "TRF2-interacting telomeric protein/Rap1, C-terminal [IPR021661]", "TRIAD supradomain [IPR044066]", "TRIM21, PRY/SPRY domain [IPR035831]", "TRIM25, PRY/SPRY domain [IPR042753]", "TRIM27, PRY/SPRY domain [IPR035791]", "TRIM4, PRY/SPRY domain [IPR035829]", "TRMT2A, RNA recognition motif [IPR034262]", "TROVE domain [IPR008858]", "TSG101 and ALIX binding domain of CEP55 [IPR022008]", "TUG ubiquitin-like domain [IPR021569]", "TUP1-like enhancer of split [IPR011494]", "TUTase nucleotidyltransferase domain [IPR045100]", "Talin, N-terminal F0 domain [IPR032425]", "Talin, central [IPR015224]", "Talin-1/2, rod-segment [IPR037438]", "Tankyrase 1-binding protein, C-terminal [IPR032764]", "Target SNARE coiled-coil homology domain [IPR000727]", "TatSF1-like, RNA recognition motif 1 [IPR034392]", "TauD/TfdA-like domain [IPR003819]", "Telomerase activating protein Est1, N-terminal [IPR019458]", "Telomere length regulation protein, conserved domain [IPR019337]", "Telomere-associated protein Rif1, N-terminal [IPR022031]", "Tensin phosphatase, C2 domain [IPR014020]", "Tensin-type phosphatase domain [IPR029023]", "Testin, LIM domain 1 [IPR034958]", "Testin, LIM domain 2 [IPR034959]", "Testin, LIM domain 3 [IPR034960]", "Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain [IPR020631]", "Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain [IPR020630]", "Tetrapyrrole methylase [IPR000878]", "Tetratricopeptide repeat-like domain [IPR018704]", "Tetratricopeptide, SHNi-TPR domain [IPR019544]", "Tfc3, extended winged-helix domain [IPR035625]", "Thiamine pyrophosphate enzyme, C-terminal TPP-binding [IPR011766]", "Thiamine pyrophosphate enzyme, N-terminal TPP-binding domain [IPR012001]", "Thiamine pyrophosphate enzyme, central domain [IPR012000]", "Thioesterase [IPR001031]", "Thioesterase domain [IPR006683]", "Thiolase, C-terminal [IPR020617]", "Thiolase, N-terminal [IPR020616]", "Thioredoxin domain [IPR013766]", "Thioredoxin domain-containing protein 17-like domain [IPR010357]", "Thioredoxin-like fold [IPR012336]", "Thioredoxin-related transmembrane protein 2, thioredoxin domain [IPR037463]", "Threonine-tRNA ligase catalytic core domain [IPR033728]", "Threonyl/alanyl tRNA synthetase, SAD [IPR012947]", "Thymidylate kinase-like domain [IPR039430]", "Thymidylate synthase/dCMP hydroxymethylase domain [IPR023451]", "Tim10-like [IPR004217]", "Tim44-like domain [IPR007379]", "Toll/interleukin-1 receptor homology (TIR) domain [IPR000157]", "TopBP1, first BRCT domain [IPR044737]", "Topoisomerase I C-terminal domain [IPR025834]", "Trafficking protein particle complex subunit 11 [IPR021773]", "Trafficking protein particle complex subunit 11, C-terminal [IPR025876]", "Trans-isoprenyl diphosphate synthases, head-to-head [IPR033904]", "Transcription elongation factor S-II, central domain [IPR003618]", "Transcription elongation factor Spt6, YqgF domain [IPR028231]", "Transcription elongation factor Spt6, helix-hairpin-helix motif [IPR032706]", "Transcription elongation factor, TFIIS/CRSP70, N-terminal, sub-type [IPR003617]", "Transcription factor CBF/NF-Y/archaeal histone domain [IPR003958]", "Transcription factor CP2, SAM domain [IPR037599]", "Transcription factor IIIC subunit 5, HTH domain [IPR019136]", "Transcription factor IIIC subunit Tfc1/Sfc1, triple barrel domain [IPR041499]", "Transcription factor IIIC, 90kDa subunit, N-terminal [IPR024761]", "Transcription factor IIIC, putative zinc-finger [IPR024764]", "Transcription factor IIS, N-terminal [IPR017923]", "Transcription factor TFE/TFIIEalpha HTH domain [IPR017919]", "Transcription factor TFIIE alpha subunit, C-terminal [IPR021600]", "Transcription factor TFIIE beta subunit, DNA-binding domain [IPR003166]", "Transcription factor Tfb2, C-terminal domain [IPR040662]", "Transcription initiation factor IIE subunit alpha, N-terminal [IPR002853]", "Transcription termination and cleavage factor, C-terminal domain [IPR026896]", "Transcriptional coactivator p15 (PC4), C-terminal [IPR003173]", "Transcriptional repressor p66, coiled-coil MBD2-interaction domain [IPR032346]", "Transferrin receptor protein 1/2, PA domain [IPR037324]", "Transferrin receptor-like, dimerisation domain [IPR007365]", "Transforming acidic coiled-coil-containing protein, C-terminal [IPR007707]", "Transketolase, C-terminal domain [IPR033248]", "Transketolase, N-terminal [IPR005474]", "Transketolase-like, pyrimidine-binding domain [IPR005475]", "Translation elongation factor EF1B, beta/delta subunit, guanine nucleotide exchange domain [IPR014038]", "Translation elongation factor EFG/EF2, domain IV [IPR005517]", "Translation elongation factor EFTs/EF1B, dimerisation [IPR014039]", "Translation elongation factor EFTu-like, domain 2 [IPR004161]", "Translation elongation factor EFTu/EF1A, C-terminal [IPR004160]", "Translation elongation factor, IF5A C-terminal [IPR020189]", "Translation initiation factor IF- 2, domain 3 [IPR023115]", "Translation initiation factor IF2/IF5 domain [IPR002735]", "Translation initiation factor eIF-2B subunit epsilon, N-terminal [IPR035543]", "Translation initiation factor eIF-2B subunit epsilon, W2 domain [IPR044123]", "Translation initiation factor, beta propellor-like domain [IPR013979]", "Translational (tr)-type GTP-binding domain [IPR000795]", "Translationally controlled tumour protein (TCTP) domain [IPR034737]", "Translocon Sec61/SecY, plug domain [IPR019561]", "Transmembrane protein 201, C-terminal [IPR018861]", "Treacle protein domain [IPR003993]", "Tripartite DENN domain [IPR037516]", "Tripeptidyl-peptidase II domain [IPR034051]", "Trm3/ TARBP1, C-terminal [IPR044748]", "TrmE-type guanine nucleotide-binding domain [IPR031168]", "TryX and NRX, thioredoxin domain [IPR045870]", "Tubulin binding cofactor C-like domain [IPR012945]", "Tubulin-folding cofactor B, N-terminal ubiquitin-like domain [IPR045172]", "Tubulin-specific chaperone D, C-terminal [IPR022577]", "Tubulin/FtsZ, 2-layer sandwich domain [IPR018316]", "Tubulin/FtsZ, GTPase domain [IPR003008]", "Tudor domain [IPR002999]", "Tuftelin interacting protein, N-terminal domain [IPR022159]", "Tumour suppressor p53-binding protein-1 Tudor domain [IPR015125]", "Tyrosine-protein kinase BAZ1B, bromodomain [IPR037375]", "Tyrosine-protein kinase Lyn, SH2 domain [IPR035852]", "Tyrosine-protein kinase Lyn, SH3 domain [IPR035748]", "Tyrosine-protein kinase ephrin type A/B receptor-like [IPR011641]", "Tyrosine-protein kinase, catalytic domain [IPR020635]", "Tyrosine-specific protein phosphatase, PTPase domain [IPR000242]", "Tyrosine-specific protein phosphatases domain [IPR000387]", "U-box domain [IPR003613]", "U1 small nuclear ribonucleoprotein A, RNA recognition motif 1 [IPR034407]", "U1 small nuclear ribonucleoprotein A, RNA recognition motif 2 [IPR034409]", "U1 small nuclear ribonucleoprotein of 70kDa N-terminal [IPR022023]", "U1-C, C2H2-type zinc finger [IPR013085]", "U2 small nuclear ribonucleoprotein B'', RNA recognition motif 2 [IPR034562]", "U2 small nuclear ribonucleoprotein B'', RNA recognition motif 1 [IPR034564]", "U2A'/phosphoprotein 32 family A, C-terminal [IPR003603]", "U3 small nucleolar RNA-associated protein 10, N-terminal [IPR022125]", "U3 small nucleolar RNA-associated protein 15, C-terminal [IPR018983]", "UAS [IPR006577]", "UBAC1, UBA domain 1 [IPR041926]", "UBAC1, UBA domain 2 [IPR041927]", "UBX domain [IPR001012]", "UBXN1, UBA domain [IPR041923]", "UDP-N-acetylglucosamine 2-epimerase domain [IPR003331]", "UDP-glucose/GDP-mannose dehydrogenase, C-terminal [IPR014027]", "UDP-glucose/GDP-mannose dehydrogenase, N-terminal [IPR001732]", "UDP-glucose/GDP-mannose dehydrogenase, dimerisation [IPR014026]", "UDP-glucose:glycoprotein glucosyltransferase, thioredoxin-like domain 4 [IPR040525]", "UDP-glycosyltransferase family, conserved site [IPR035595]", "UGGT, thioredoxin-like domain 1 [IPR040693]", "UGGT, thioredoxin-like domain 2 [IPR040694]", "UGGT, thioredoxin-like domain 3 [IPR040692]", "UHRF1, tandem tudor domain [IPR021991]", "UNC-45/Cro1/She4, central domain [IPR024660]", "UPF0113, PUA domain [IPR005155]", "UPF0113, pre-PUA domain [IPR040598]", "UPF3 domain [IPR005120]", "UPF3B, RNA recognition motif-like domain [IPR034979]", "UVR domain [IPR001943]", "Ubiquinol-cytochrome c reductase 8kDa, N-terminal [IPR015248]", "Ubiquinol-cytochrome c reductase, iron-sulphur subunit [IPR006317]", "Ubiquitin E2 variant, N-terminal [IPR008883]", "Ubiquitin carboxyl-terminal hydrolase 47, C-terminal [IPR045578]", "Ubiquitin carboxyl-terminal hydrolase 5, UBA1 domain [IPR041812]", "Ubiquitin carboxyl-terminal hydrolase 7, ICP0-binding domain [IPR024729]", "Ubiquitin carboxyl-terminal hydrolase, C-terminal [IPR029346]", "Ubiquitin conjugation factor E4, core [IPR019474]", "Ubiquitin specific protease domain [IPR028889]", "Ubiquitin system component CUE [IPR003892]", "Ubiquitin-activating enzyme E1, C-terminal [IPR018965]", "Ubiquitin-activating enzyme E1, FCCH domain [IPR032418]", "Ubiquitin-activating enzyme E1, four-helix bundle [IPR032420]", "Ubiquitin-activating enzyme, SCCH domain [IPR019572]", "Ubiquitin-associated domain [IPR015940]", "Ubiquitin-conjugating enzyme E2 [IPR000608]", "Ubiquitin-like domain [IPR000626]", "Ubiquitin-like domain, USP-type [IPR028135]", "Ubiquitin-protein ligase E3A, N-terminal zinc-binding domain [IPR032353]", "Ubiquitin-specific peptidase 48 [IPR033841]", "Ubiquitin-specific-processing protease 48, Ubl domain [IPR044743]", "Ubiquitin/SUMO-activating enzyme ubiquitin-like domain [IPR028077]", "Ubiquitinyl hydrolase, variant UBP zinc finger [IPR041432]", "Ubiquitinyl hydrolase-L5 [IPR033837]", "Ulp1 protease family, C-terminal catalytic domain [IPR003653]", "Uncharacterised domain CHP00451 [IPR004521]", "Uncharacterised domain NUC130/133, N-terminal [IPR012977]", "Uncharacterised domain NUC173 [IPR012978]", "Uncharacterised domain NUC202 [IPR012980]", "Up-frameshift suppressor 2, C-terminal [IPR007193]", "Uroporphyrinogen decarboxylase (URO-D) [IPR000257]", "Uso1/p115-like vesicle tethering protein, C-terminal [IPR006955]", "VASP tetramerisation [IPR014885]", "VHS domain [IPR002014]", "VIP36, lectin domain [IPR035664]", "VPS10 [IPR006581]", "VPS13, repeated coiled region [IPR031642]", "VPS9 domain [IPR003123]", "Vacuolar protein sorting-associated protein 13, C-terminal [IPR031645]", "Vacuolar protein sorting-associated protein 13, SHR-binding domain [IPR009543]", "Vacuolar protein sorting-associated protein 13, second N-terminal domain [IPR031646]", "Vacuolar protein sorting-associated protein 13-like, N-terminal domain [IPR026854]", "Vacuolar protein sorting-associated protein 4, MIT domain [IPR045253]", "Vacuolar protein sorting-associated protein 54, N-terminal [IPR019515]", "Vacuolar sorting protein 39/Transforming growth factor beta receptor-associated domain 1 [IPR019452]", "Vacuolar sorting protein 39/Transforming growth factor beta receptor-associated domain 2 [IPR019453]", "Valyl tRNA synthetase, anticodon-binding domain [IPR033705]", "Vertebrate SNX3, PX domain [IPR042137]", "Vertebrate ubiquitin-conjugating enzyme E2 K, UBA domain [IPR042599]", "Very large inducible GTPASE (VLIG)-type guanine nucleotide-binding (G) domain [IPR030383]", "Vesicle tethering protein Uso1/P115-like , head domain [IPR006953]", "Vicinal oxygen chelate (VOC) domain [IPR037523]", "Vinculin-binding site-containing domain [IPR015009]", "Virilizer, N-terminal [IPR031801]", "Vitamin B12-dependent methionine synthase, activation domain [IPR004223]", "Vps16, C-terminal [IPR006925]", "Vps16, N-terminal [IPR006926]", "Vps4 oligomerisation, C-terminal [IPR015415]", "Vps53-like, N-terminal [IPR007234]", "Vta1, C-terminal [IPR041212]", "Vta1/callose synthase, N-terminal [IPR039431]", "W2 domain [IPR003307]", "WAPL domain [IPR012502]", "WASH complex subunit 4, N-terminal [IPR028191]", "WASH complex subunit 7, C-terminal [IPR028283]", "WASH complex subunit 7, central domain [IPR028282]", "WD repeat-containing protein 18, C-terminal domain [IPR026987]", "WGR domain [IPR008893]", "WH1/EVH1 domain [IPR000697]", "WH2 domain [IPR003124]", "WHEP-TRS domain [IPR000738]", "WHIM1 domain [IPR028942]", "WHIM2 domain [IPR028941]", "WRNIP1, ubiquitin-binding domain [IPR040539]", "WSTF/Acf1/Cbp146 [IPR013136]", "WW domain [IPR001202]", "WWE domain [IPR004170]", "Wings apart-like protein, C-terminal [IPR022771]", "Wolframin, EF-hand domain [IPR045460]", "Wolframin, OB-fold domain [IPR045461]", "Wolframin, cysteine-rich domain [IPR045400]", "XPC-binding domain [IPR015360]", "XPG, N-terminal [IPR006085]", "XPG-I domain [IPR006086]", "XRCC1, first (central) BRCT domain [IPR045080]", "XRN2-binding (XTBD) domain [IPR021859]", "Xrn1, helical domain [IPR041412]", "YKT6, SNARE motif [IPR045848]", "YTH domain [IPR007275]", "YchF, C-terminal domain [IPR013029]", "YchF, N-terminal [IPR041706]", "YjeF N-terminal domain [IPR004443]", "YqgF/RNase H-like domain [IPR006641]", "Z-binding domain [IPR042371]", "ZAP, helix turn helix N-terminal domain [IPR041360]", "ZAP, zinc finger [IPR040954]", "ZC3H15/TMA46 family, C-terminal [IPR032378]", "ZN598/Hel2, RING finger [IPR041888]", "ZN622/Rei1/Reh1, zinc finger C2H2-type [IPR041661]", "ZO-1, SH3 domain [IPR035597]", "ZO-2, SH3 domain [IPR035598]", "ZU5 domain [IPR000906]", "ZZEF1, zinc finger, ZZ-type [IPR041986]", "Zasp-like motif [IPR006643]", "Zinc finger C2H2 AKAP95-type [IPR034736]", "Zinc finger C2H2-type [IPR013087]", "Zinc finger, B-box, chordata [IPR020457]", "Zinc finger, C2H2, LYAR-type [IPR014898]", "Zinc finger, C2HC5-type [IPR009349]", "Zinc finger, C3HC4 RING-type [IPR018957]", "Zinc finger, C5HC2-type [IPR004198]", "Zinc finger, CCCH-type [IPR000571]", "Zinc finger, CCHC-type [IPR001878]", "Zinc finger, CHCC-type [IPR019401]", "Zinc finger, CHHC-type [IPR012996]", "Zinc finger, CW-type [IPR011124]", "Zinc finger, CXXC-type [IPR002857]", "Zinc finger, ClpX C4-type [IPR010603]", "Zinc finger, DNA-directed DNA polymerase, family B, alpha [IPR015088]", "Zinc finger, FPG/IleRS-type [IPR010663]", "Zinc finger, FYVE-related [IPR017455]", "Zinc finger, GATA-type [IPR000679]", "Zinc finger, GRF-type [IPR010666]", "Zinc finger, LIM-type [IPR001781]", "Zinc finger, MIZ-type [IPR004181]", "Zinc finger, MYM-type [IPR010507]", "Zinc finger, MYND-type [IPR002893]", "Zinc finger, Mcm10/DnaG-type [IPR015408]", "Zinc finger, NF-X1-type [IPR000967]", "Zinc finger, PARP-type [IPR001510]", "Zinc finger, PHD-finger [IPR019787]", "Zinc finger, PHD-type [IPR001965]", "Zinc finger, RING-CH-type [IPR011016]", "Zinc finger, RING-type [IPR001841]", "Zinc finger, RanBP2-type [IPR001876]", "Zinc finger, Sec23/Sec24-type [IPR006895]", "Zinc finger, TFIIB-type [IPR013137]", "Zinc finger, TFIIS-type [IPR001222]", "Zinc finger, TRAF-type [IPR001293]", "Zinc finger, UBP-type [IPR001607]", "Zinc finger, UBR-type [IPR003126]", "Zinc finger, ZPR1-type [IPR004457]", "Zinc finger, ZZ-type [IPR000433]", "Zinc finger, double-stranded RNA binding [IPR022755]", "Zinc knuckle CX2CX3GHX4C [IPR025829]", "Zinc-finger CCCH domain [IPR041686]", "Zinc-finger domain of monoamine-oxidase A repressor R1 [IPR018866]", "Zinc-ribbon domain [IPR026870]", "Zn-dependent metallo-hydrolase, RNA specificity domain [IPR011108]", "bMERB domain [IPR022735]", "cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain [IPR003117]", "dUTPase, trimeric [IPR033704]", "dUTPase-like [IPR029054]", "eIF3 subunit M, C-terminal helix domain [IPR040750]", "eIF3B, RNA recognition motif [IPR034363]", "eIF3G, RNA recognition motif [IPR034240]", "eIF3h, C-terminal [IPR045810]", "eIF4H, RNA recognition motif [IPR034229]", "eRF1 domain 1/Pelota-like [IPR005140]", "eRF1 domain 2 [IPR005141]", "eRF1 domain 3 [IPR005142]", "hnRNP A0, RNA recognition motif 1 [IPR034801]", "hnRNP A1, RNA recognition motif 1 [IPR034845]", "hnRNP A1, RNA recognition motif 2 [IPR034803]", "hnRNP A2/B1, RNA recognition motif 1 [IPR034486]", "hnRNP A3, RNA recognition motif 1 [IPR034513]", "hnRNP A3, RNA recognition motif 2 [IPR034516]", "hnRNP DL, RNA recognition motif 1 [IPR034847]", "hnRNP-L, RNA recognition motif 1 [IPR035005]", "hnRNP-L, RNA recognition motif 2 [IPR035008]", "hnRNP-L, RNA recognition motif 3 [IPR034816]", "hnRNP-L, RNA recognition motif 4 [IPR034817]", "hnRNPAB, RNA recognition motif 1 [IPR034846]", "hnRNPH3, RNA recognition motif 2 [IPR034970]", "hnRNPH3, RNA recognition motif 3 [IPR034969]", "hnRNPM, RNA recognition motif 3 [IPR034990]", "hnRPLL, RNA recognition motif 1 [IPR034985]", "hnRPLL, RNA recognition motif 2 [IPR034986]", "hnRPLL, RNA recognition motif 3 [IPR034983]", "hnRPLL, RNA recognition motif 4 [IPR034987]", "mRNA (guanine-N(7))-methyltransferase domain [IPR004971]", "mRNA decay factor PAT1 domain [IPR019167]", "mRNA splicing factor Cwf21 domain [IPR013170]", "mRNA-decapping enzyme, C-terminal [IPR031953]", "p21 activated kinase binding domain [IPR033923]", "p21-activated kinase 2, catalytic domain [IPR035064]", "p53 transactivation domain [IPR013872]", "p53, DNA-binding domain [IPR011615]", "p53, tetramerisation domain [IPR010991]", "p54nrb, RNA recognition motif 1 [IPR034552]", "rRNA-processing arch domain [IPR025696]", "snRNP70, RNA recognition motif [IPR034143]", "tRNA methyltransferase TRM10-type domain [IPR028564]", "tRNA methyltransferase TRMD/TRM10-type domain [IPR016009]", "tRNA pseudouridylate synthase B, C-terminal [IPR032819]", "tRNA synthetase, B5-domain [IPR005147]", "tRNA synthetases class I, catalytic domain [IPR032678]", "tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG, C-terminal [IPR026904]", "tRNA(Met) cytidine acetyltransferase TmcA, N-terminal [IPR013562]", "tRNA-binding domain [IPR002547]", "tRNA-guanine(15) transglycosylase-like [IPR002616]", "tRNA/rRNA methyltransferase, SpoU type [IPR001537]", "tRNase Z endonuclease [IPR027794]", "v-SNARE, coiled-coil homology domain [IPR042855]", "von Willebrand factor, type A [IPR002035]"], "available_proteins": ["AAR2", "AARS", "AARS2", "AASDHPPT", "AASS", "AATF", "ABCB1", "ABCB10", "ABCB6", "ABCB7", "ABCB8", "ABCC4", "ABCD3", "ABCE1", "ABCF1", "ABCF2", "ABCF3", "ABHD10", "ABHD12", "ABHD14B", "ABHD6", "ABRACL", "ABRAXAS2", "ACAA1", "ACAA2", "ACACA", "ACACB", "ACAD11", "ACAD9", "ACADM", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACBD5", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT9", "ACOX1", "ACOX3", "ACP1", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACSL6", "ACTN1", "ACTN4", "ADA", "ADAR", "ADD1", "ADD3", "ADH5", "ADK", "ADNP", "ADRM1", "ADSL", "AFDN", "AFG3L2", "AGK", "AGL", "AGPAT1", "AGPAT5", "AGPS", "AHCTF1", "AHCY", "AHCYL1", "AHNAK", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK2", "AK3", "AK4", "AKAP1", "AKAP10", "AKAP8", "AKAP8L", "AKAP9", "AKR1A1", "AKR1B1", "AKR7A2", "AKT2", "ALDH16A1", "ALDH18A1", "ALDH1A2", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALG1", "ALG11", "ALG5", "ALKBH5", "ALYREF", "AMOT", "ANAPC1", "ANAPC2", "ANAPC4", "ANAPC5", "ANGEL1", "ANK3", "ANKFY1", "ANKHD1", "ANKLE2", "ANKRD17", "ANLN", "ANO6", "ANP32A", "ANP32B", "AP1B1", "AP1G1", "AP1M1", "AP1S1", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "APEH", "APEX1", "APMAP", "APP", "APPL1", "APRT", "AQR", "ARCN1", "ARF4", "ARF6", "ARFGAP1", "ARFIP1", "ARFIP2", "ARHGAP17", "ARHGEF2", "ARID1A", "ARID2", "ARID3B", "ARIH2", "ARL1", "ARL2", "ARL3", "ARL8A", "ARMC10", "ARMCX3", "ARMT1", "ASAH1", "ASB6", "ASCC2", "ASCC3", "ASH2L", "ASNA1", "ASNS", "ASPH", "ASPSCR1", "ATAD1", "ATAD2", "ATAD3A", "ATAD3B", "ATAD5", "ATIC", "ATL2", "ATP13A1", "ATP1A1", "ATP2A2", "ATP2B1", "ATP2B4", "ATP2C1", "ATP5A1", "ATP5B", "ATP6V1A", "ATP6V1B2", "ATP6V1H", "ATP7A", "ATP7B", "ATXN10", "ATXN2L", "AUP1", "AURKA", "BAG2", "BAG3", "BAG4", "BAG5", "BAG6", "BAIAP2", "BAP18", "BARD1", "BAZ1A", "BAZ1B", "BAZ2A", "BCAP31", "BCAS3", "BCKDK", "BCR", "BCS1L", "BIRC6", "BLM", "BLVRA", "BMS1", "BOP1", "BPTF", "BRAP", "BRCA1", "BRD1", "BRD2", "BRD4", "BRIX1", "BSG", "BTAF1", "BTF3", "BUB1B", "BUD23", "BZW1", "BZW2", "C1orf35", "C2CD5", "CACYBP", "CAD", "CALU", "CAMK2G", "CAMSAP3", "CAND1", "CAND2", "CAP1", "CAPN1", "CAPN2", "CAPNS1", "CAPRIN1", "CARHSP1", "CARS", "CASK", "CBX1", "CBX2", "CBX3", "CBX5", "CBX8", "CC2D1A", "CCAR1", "CCAR2", "CCDC93", "CCDC97", "CCNB1", "CD2AP", "CD2BP2", "CD47", "CDC23", "CDC37", "CDC42", "CDC5L", "CDC73", "CDCA2", "CDCA7L", "CDCA8", "CDH2", "CDK1", "CDK12", "CDK2", "CDK4", "CDK5", "CDK5RAP1", "CDK6", "CDK9", "CDKAL1", "CDKN2AIP", "CEBPZ", "CELF1", "CELF2", "CENPB", "CENPV", "CEP170", "CEP44", "CEP55", "CEP72", "CERS2", "CERS5", "CETN2", "CFAP20", "CFL1", "CFL2", "CHAC2", "CHAF1A", "CHAF1B", "CHAMP1", "CHD1", "CHD1L", "CHD4", "CHD8", "CHDH", "CHERP", "CHID1", "CHORDC1", "CHRAC1", "CHTF18", "CHTOP", "CIAPIN1", "CIB1", "CIRBP", "CISD2", "CIT", "CIZ1", "CKAP2", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLASP2", "CLCN3", "CLCN7", "CLIC1", "CLINT1", "CLPB", "CLPX", "CLTC", "CLUH", "CMTR1", "CNDP2", "CNN2", "CNN3", "CNNM3", "CNNM4", "CNOT1", "CNOT4", "COA3", "COG2", "COG4", "COIL", "COL4A3BP", "COLEC12", "COMMD8", "COPA", "COPB1", "COPB2", "COPG1", "COPG2", "COPS2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS8", "COPZ1", "COQ8A", "COQ9", "CORO1B", "CORO1C", "CORO7", "COTL1", "COX2", "COX6C", "CPD", "CPNE1", "CPNE2", "CPNE3", "CPNE8", "CPSF1", "CPSF2", "CPSF3", "CPSF6", "CPSF7", "CPT1A", "CPT2", "CRK", "CRKL", "CRYZ", "CSDE1", "CSE1L", "CSK", "CSNK1A1", "CSNK2A1", "CSNK2A2", "CSRP2", "CSTB", "CSTF1", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTNNBL1", "CTPS1", "CTPS2", "CTSC", "CTTN", "CTTNBP2NL", "CUL1", "CUL2", "CUL3", "CUL4A", "CUL4B", "CUL5", "CWC22", "CWF19L1", "CXADR", "CYB5B", "CYB5R1", "CYB5R3", "CYFIP1", "CYFIP2", "DAGLB", "DARS", "DARS2", "DAZAP1", "DBN1", "DBNL", "DBT", "DCAF1", "DCAF13", "DCP1B", "DCTD", "DCTN1", "DCUN1D1", "DCUN1D5", "DDB1", "DDI2", "DDX1", "DDX10", "DDX17", "DDX18", "DDX20", "DDX21", "DDX23", "DDX24", "DDX27", "DDX28", "DDX39A", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX50", "DDX51", "DDX52", "DDX54", "DDX56", "DDX6", "DEK", "DENND6A", "DENR", "DFFA", "DHCR24", "DHFR", "DHTKD1", "DHX15", "DHX16", "DHX29", "DHX30", "DHX36", "DHX37", "DHX38", "DHX40", "DHX57", "DHX8", "DHX9", "DIAPH1", "DIAPH2", "DIAPH3", "DICER1", "DIDO1", "DIMT1", "DIS3", "DKC1", "DLAT", "DLD", "DLG1", "DLST", "DMAP1", "DNA2", "DNAAF5", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC13", "DNAJC16", "DNAJC2", "DNAJC21", "DNAJC3", "DNAJC7", "DNAJC8", "DNAJC9", "DNM1L", "DNM2", "DNMT1", "DNTTIP2", "DOCK7", "DOLPP1", "DPF2", "DPH5", "DPM1", "DPP9", "DPYSL2", "DPYSL3", "DPYSL5", "DRG1", "DRG2", "DSC3", "DSG2", "DSP", "DST", "DSTN", "DTX3L", "DTYMK", "DUS2", "DUSP12", "DUSP3", "DUSP9", "DUT", "DYNC1H1", "DYNC2H1", "EARS2", "EBP", "ECE1", "ECI2", "ECSIT", "EDC3", "EDC4", "EDF1", "EEA1", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EFCAB14", "EFL1", "EFTUD2", "EHBP1", "EHD1", "EHD4", "EIF2A", "EIF2AK2", "EIF2B3", "EIF2B5", "EIF2D", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "ELAC2", "ELAVL1", "ELL", "ELMO2", "ELMOD2", "ELOA", "ELOB", "ELP3", "EMC1", "EMC7", "EMD", "EML4", "ENAH", "ENDOD1", "ENO1", "ENO2", "EP400", "EPB41", "EPB41L2", "EPB41L3", "EPB41L5", "EPHA7", "EPHX1", "EPHX2", "EPN1", "EPRS", "EPS15L1", "ERAL1", "ERAP1", "ERAP2", "ERBIN", "ERC1", "ERCC2", "ERCC3", "ERCC6L", "ERGIC1", "ERGIC3", "ERLIN1", "ERLIN2", "ERMP1", "ERP29", "ESF1", "ESYT1", "ESYT2", "ETF1", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXD2", "EXO1", "EXOC2", "EXOC8", "EXOSC1", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC8", "EXOSC9", "EYA4", "EZR", "F11R", "FADS2", "FAF1", "FAF2", "FAH", "FAHD1", "FAHD2A", "FAM129B", "FAM192A", "FAM208A", "FAM49B", "FANCI", "FAR1", "FARP1", "FARP2", "FARSA", "FARSB", "FASN", "FASTKD5", "FDFT1", "FDXR", "FECH", "FEN1", "FERMT2", "FGFR1OP", "FH", "FHL1", "FHOD1", "FIP1L1", "FIS1", "FKBP10", "FKBP14", "FKBP2", "FKBP3", "FKBP4", "FKBP5", "FKBP7", "FKBP8", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FMR1", "FNBP4", "FNDC3A", "FOCAD", "FOXC1", "FOXK1", "FOXRED1", "FRYL", "FSCN1", "FSD1", "FTO", "FTSJ3", "FUBP1", "FUBP3", "FUCA1", "FUCA2", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GAK", "GALK1", "GALNS", "GALNT1", "GALNT2", "GALNT4", "GALNT7", "GANAB", "GAPDH", "GAPVD1", "GARS", "GART", "GATAD2A", "GATAD2B", "GATB", "GBA", "GBF1", "GCAT", "GCDH", "GCFC2", "GCN1", "GDAP1", "GDPD1", "GEMIN5", "GFM1", "GFPT1", "GGA1", "GGCT", "GGCX", "GHITM", "GIGYF2", "GINS2", "GINS3", "GINS4", "GLA", "GLB1", "GLCE", "GLDC", "GLO1", "GLOD4", "GLRX3", "GLRX5", "GLS", "GLTP", "GLUD1", "GLYR1", "GM2A", "GMFB", "GMPS", "GNE", "GNG12", "GNG5", "GNL1", "GNL2", "GNL3", "GNL3L", "GNPAT", "GNPDA1", "GNPNAT1", "GNS", "GOLGA2", "GOLGB1", "GORASP2", "GOT1", "GOT2", "GPAM", "GPAT4", "GPATCH4", "GPATCH8", "GPD1L", "GPD2", "GPHN", "GPI", "GPKOW", "GPR89B", "GPRASP2", "GPS1", "GPT2", "GRB2", "GRHPR", "GRSF1", "GRWD1", "GSK3B", "GSPT1", "GSR", "GSS", "GSTK1", "GSTM3", "GSTO1", "GSTZ1", "GTF2E1", "GTF2E2", "GTF2H1", "GTF2H4", "GTF3C1", "GTF3C4", "GTF3C5", "GTPBP1", "GTPBP10", "GTPBP3", "GTPBP4", "GUF1", "H1F0", "H1FX", "H2AFY", "H2AFY2", "H4C1*", "HACD3", "HACL1", "HADH", "HADHA", "HADHB", "HARS2", "HAT1", "HAUS3", "HAUS6", "HBS1L", "HCFC1", "HDAC1", "HDAC2", "HDGF", "HDGFL2", "HDGFL3", "HDLBP", "HEATR1", "HEATR6", "HECTD1", "HECTD3", "HELLS", "HEXA", "HEXB", "HGH1", "HGS", "HIBADH", "HIBCH", "HINT2", "HINT3", "HIRA", "HIRIP3", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLTF", "HMBS", "HMGB1", "HMGB2", "HMGB3", "HMGCL", "HMGCR", "HMGCS1", "HMMR", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPLL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HNRNPUL2", "HOOK2", "HOOK3", "HP1BP3", "HPRT1", "HSD17B4", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA14", "HSPA4", "HSPA4L", "HSPBP1", "HSPH1", "HTATSF1", "HUWE1", "IARS", "IARS2", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDH3G", "IDI1", "IFT27", "IFT81", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IK", "IKBKB", "ILF2", "ILF3", "ILK", "ILKAP", "ILVBL", "IMP3", "IMP4", "IMPDH1", "IMPDH2", "INA", "INF2", "INPP4A", "INPPL1", "INTS1", "INTS11", "INTS14", "INTS3", "INTS9", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IQGAP3", "IRF2BPL", "IRGQ", "IRS4", "ISG20L2", "ISOC1", "ISYNA1", "ITCH", "ITGB1", "ITM2C", "ITPK1", "ITSN2", "IVD", "IWS1", "JMJD6", "KARS", "KAT7", "KCTD12", "KDELC2", "KDM1A", "KDM1B", "KDM2A", "KDM3B", "KDM5A", "KHDRBS1", "KHDRBS3", "KHSRP", "KIAA0319L", "KIAA0391", "KIAA1147", "KIAA1468", "KIDINS220", "KIF11", "KIF14", "KIF18A", "KIF18B", "KIF1A", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF3A", "KIF4A", "KIF5B", "KIN", "KLHL11", "KMT2A", "KNOP1", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNA6", "KPNB1", "KRI1", "KRR1", "KTN1", "KYAT3", "L2HGDH", "LACTB", "LAMB1", "LAMC1", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LASP1", "LBR", "LCLAT1", "LDHA", "LDHB", "LDLR", "LEMD3", "LETM1", "LGALS3", "LGALS3BP", "LIG1", "LIG3", "LIMA1", "LIN9", "LIPA", "LLGL1", "LMAN2", "LMAN2L", "LMNA", "LMNB1", "LMNB2", "LNPEP", "LNPK", "LONP1", "LPCAT1", "LPGAT1", "LRBA", "LRP1", "LRPAP1", "LRPPRC", "LRRC47", "LRRC8C", "LRSAM1", "LSM12", "LSM14B", "LSM2", "LSM4", "LSM6", "LSM7", "LSS", "LTA4H", "LTN1", "LYAR", "LYN", "LYPLA1", "M6PR", "MACF1", "MAEA", "MAGED2", "MAK16", "MALT1", "MAN2A1", "MAN2B1", "MANF", "MAPK1", "MAPK14", "MAPRE1", "MAPRE2", "MARC1", "MARCH5", "MARS", "MARS2", "MAT2A", "MAT2B", "MATR3", "MAVS", "MBD3", "MCAM", "MCCC1", "MCCC2", "MCM10", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCU", "MCUB", "MDC1", "MDH1", "MDH2", "MDN1", "ME1", "ME2", "MECP2", "MEPCE", "METAP1", "METAP2", "METTL13", "METTL7B", "MFN1", "MFN2", "MFSD10", "MIA2", "MIA3", "MICU1", "MIEF1", "MINDY3", "MIPEP", "MKI67", "MKLN1", "MKRN2", "MLEC", "MMAB", "MMS19", "MOCOS", "MOGS", "MON2", "MORC2", "MORF4L1", "MORF4L2", "MOSPD2", "MOV10", "MPHOSPH8", "MPP1", "MPP2", "MPP6", "MPP7", "MPRIP", "MPST", "MRC2", "MRE11", "MRPL11", "MRPL12", "MRPL15", "MRPL2", "MRPL24", "MRPL39", "MRPL43", "MRPL44", "MRPL45", "MRPL46", "MRPL48", "MRPL58", "MRPL9", "MRPS23", "MRPS25", "MRPS35", "MRPS5", "MRPS7", "MRRF", "MRTO4", "MSH2", "MSH3", "MSH6", "MSI1", "MSI2", "MSMO1", "MSN", "MSTO1", "MTA1", "MTA2", "MTAP", "MTBP", "MTHFD1", "MTHFD1L", "MTHFD2", "MTMR14", "MTMR2", "MTMR6", "MTO1", "MTOR", "MTPAP", "MTR", "MTX1", "MTX2", "MTX3", "MUL1", "MUT", "MVD", "MYCBP2", "MYEF2", "MYH10", "MYH14", "MYH9", "MYL6", "MYO18A", "MYO1B", "MYO1C", "MYO1D", "MYO6", "NAA10", "NAA40", "NAA50", "NAE1", "NAGLU", "NAMPT", "NANS", "NARS", "NASP", "NAT10", "NAXE", "NBAS", "NBN", "NCAPD2", "NCAPD3", "NCAPG", "NCBP1", "NCEH1", "NCKIPSD", "NCL", "NCLN", "NCOR1", "NCSTN", "NDC80", "NDUFA10", "NDUFA8", "NDUFA9", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS6", "NDUFS7", "NDUFS8", "NDUFV1", "NDUFV2", "NECAP2", "NEDD4L", "NEFL", "NEFM", "NEK9", "NELFA", "NELFE", "NEMF", "NENF", "NES", "NF1", "NFATC2IP", "NFS1", "NFU1", "NFXL1", "NHLRC2", "NHP2", "NIFK", "NIP7", "NIPBL", "NIPSNAP1", "NIPSNAP2", "NISCH", "NIT2", "NKRF", "NKTR", "NLE1", "NLN", "NLRX1", "NME1", "NME2", "NMT1", "NNT", "NOA1", "NOB1", "NOC3L", "NOC4L", "NOL10", "NOL11", "NOL6", "NOL7", "NOL8", "NOL9", "NOLC1", "NOM1", "NONO", "NOP2", "NOP56", "NOP58", "NOSIP", "NOTCH2", "NPC1", "NPC2", "NPEPPS", "NPLOC4", "NPM1", "NRBP1", "NRDC", "NRP1", "NSD1", "NSD2", "NSD3", "NSDHL", "NSF", "NSMCE2", "NSUN2", "NTHL1", "NTPCR", "NUB1", "NUCB1", "NUCB2", "NUDC", "NUDCD1", "NUDCD2", "NUDCD3", "NUDT1", "NUDT21", "NUDT5", "NUF2", "NUP133", "NUP153", "NUP155", "NUP188", "NUP210", "NUP214", "NUP35", "NUP50", "NUP54", "NUP62", "NUP98", "NUPL2", "NUTF2", "NVL", "NXF1", "NXN", "OARD1", "OCIAD1", "OCLN", "OCRL", "OGDH", "OGFOD3", "OGT", "OLA1", "OPA1", "ORC3", "ORC5", "OSBP", "OSBPL11", "OSBPL1A", "OSBPL6", "OSBPL8", "OSBPL9", "OSGEP", "OSTF1", "OTUB1", "OXA1L", "OXSR1", "P3H1", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PAFAH1B1", "PAFAH1B2", "PAFAH1B3", "PAICS", "PAK2", "PALD1", "PALLD", "PANK4", "PAPOLA", "PAPSS1", "PARD3", "PARK7", "PARN", "PARP1", "PARP2", "PATL1", "PBDC1", "PBK", "PBRM1", "PC", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCM1", "PCNA", "PCYOX1", "PDAP1", "PDCD11", "PDCD6", "PDCD6IP", "PDCL3", "PDE12", "PDHA1", "PDHB", "PDHX", "PDIA3", "PDIA4", "PDIA6", "PDK1", "PDK3", "PDLIM1", "PDLIM5", "PDP1", "PDZD8", "PEF1", "PELO", "PELP1", "PEPD", "PES1", "PEX14", "PFAS", "PFKL", "PFKM", "PFKP", "PGD", "PGLS", "PGM1", "PGM2", "PGM3", "PGRMC1", "PGRMC2", "PHB", "PHB2", "PHF10", "PHF2", "PHF3", "PHF6", "PHGDH", "PHIP", "PHKA1", "PHKB", "PI4K2A", "PI4KA", "PI4KB", "PICALM", "PIGG", "PIH1D1", "PIK3C2A", "PIK3R2", "PIK3R4", "PIN1", "PIN4", "PINX1", "PIP4K2C", "PIR", "PITHD1", "PITRM1", "PKM", "PKMYT1", "PKN1", "PKN2", "PLAA", "PLCG1", "PLD3", "PLD6", "PLEC", "PLEKHA5", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLS3", "PLXNB2", "PM20D2", "PMPCA", "PMPCB", "PNKP", "PNN", "PNO1", "PNP", "PNPLA6", "PNPLA8", "PNPT1", "POGZ", "POLA1", "POLA2", "POLD1", "POLD2", "POLDIP2", "POLDIP3", "POLE", "POLE2", "POLG", "POLR1A", "POLR1B", "POLR1C", "POLR2A", "POLR2B", "POLR2C", "POLR2D", "POLR2E", "POLR2G", "POLR3A", "POLR3B", "POLR3C", "POLRMT", "POP1", "POR", "PPAN", "PPAT", "PPCDC", "PPFIA1", "PPIB", "PPIC", "PPID", "PPIE", "PPIF", "PPIG", "PPIH", "PPIL4", "PPM1G", "PPME1", "PPOX", "PPP1CA", "PPP1CB", "PPP1R10", "PPP1R7", "PPP1R8", "PPP3CA", "PPP4R1", "PPP4R3A", "PPP5C", "PPP6C", "PPWD1", "PQBP1", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREP", "PREPL", "PRKAA1", "PRKAA2", "PRKACA", "PRKAG1", "PRKAR1A", "PRKAR2A", "PRKCB", "PRKCSH", "PRKDC", "PRMT1", "PRMT3", "PRMT5", "PRPF19", "PRPF3", "PRPF31", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPS2", "PRPSAP1", "PRPSAP2", "PRRC1", "PRRC2A", "PRRC2B", "PRRC2C", "PSAP", "PSAT1", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD11", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD6", "PSMD7", "PSMD8", "PSME1", "PSME2", "PSME3", "PSME4", "PSPC1", "PTBP1", "PTBP2", "PTCD1", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK2", "PTK7", "PTPN1", "PTPN11", "PTPN23", "PTPRF", "PUF60", "PUM3", "PUS1", "PUS7", "PUS7L", "PWP2", "PXN", "PYCR1", "PYCR2", "QARS", "QKI", "QRSL1", "QSOX2", "QTRT2", "R3HCC1", "RAB10", "RAB12", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB1B", "RAB23", "RAB24", "RAB2A", "RAB34", "RAB35", "RAB3B", "RAB3GAP1", "RAB3GAP2", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RAB8A", "RAB9A", "RABGAP1", "RABGGTA", "RAC1", "RACGAP1", "RAD18", "RAD21", "RAD23A", "RAD23B", "RAD50", "RAD54L2", "RALA", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP9", "RANGAP1", "RAPGEF2", "RARS", "RARS2", "RAVER1", "RBBP4", "RBBP6", "RBBP7", "RBM10", "RBM12", "RBM12B", "RBM14", "RBM17", "RBM19", "RBM22", "RBM25", "RBM26", "RBM27", "RBM28", "RBM3", "RBM34", "RBM39", "RBM4", "RBM45", "RBM47", "RBM5", "RBM6", "RBM8A", "RBMX", "RBMXL1", "RBPJ", "RCL1", "RCN1", "RCN2", "RDX", "RECQL", "REXO2", "REXO4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RHBDD2", "RHEB", "RHOG", "RHOT1", "RHOT2", "RIF1", "RIPK1", "RNASEH2A", "RNF2", "RNF20", "RNF40", "RNMT", "RNPEP", "RNPS1", "ROBO1", "ROCK1", "ROCK2", "RP2", "RPA1", "RPA2", "RPAP1", "RPAP3", "RPF1", "RPF2", "RPL10", "RPL11", "RPL12", "RPL14", "RPL18", "RPL18A", "RPL19", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL30", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPP38", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS2", "RPS20", "RPS3", "RPS4X", "RPS5", "RPS6KA1", "RPS6KA3", "RPS9", "RPSA", "RPTOR", "RPUSD3", "RRAS2", "RRBP1", "RREB1", "RRM1", "RRP12", "RSF1", "RSL24D1", "RSPRY1", "RTCA", "RTFDC1", "RTN1", "RTN2", "RTN3", "RTN4", "RTN4IP1", "RUFY1", "RUVBL1", "RUVBL2", "S100A11", "S100A13", "SACM1L", "SAE1", "SAFB", "SAFB2", "SALL2", "SAMD4B", "SAMHD1", "SAMM50", "SAP130", "SAR1A", "SAR1B", "SARM1", "SARNP", "SARS", "SARS2", "SART3", "SBDS", "SBNO1", "SCAF11", "SCAF4", "SCCPDH", "SCML2", "SCO2", "SCP2", "SCRIB", "SCYL1", "SDAD1", "SDF4", "SDHA", "SDHB", "SDR39U1", "SEC11A", "SEC16A", "SEC22B", "SEC23A", "SEC23B", "SEC23IP", "SEC24A", "SEC24B", "SEC24C", "SEC31A", "SEC61A1", "SEC63", "SEL1L", "SENP3", "SEPT11", "SEPT2", "SEPT7", "SEPT9", "SERBP1", "SERPINB6", "SERPINH1", "SETD1A", "SETD2", "SETD3", "SETDB1", "SEZ6L2", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFSWAP", "SGF29", "SGTA", "SH3GL1", "SH3GLB1", "SHCBP1", "SHMT1", "SHMT2", "SIN3A", "SKIV2L", "SKIV2L2", "SKP1", "SKP2", "SLC12A2", "SLC12A9", "SLC16A1", "SLC25A12", "SLC25A13", "SLC25A24", "SLC25A25", "SLC27A4", "SLC3A2", "SLC4A1AP", "SLC4A2", "SLC7A1", "SLC9A3R1", "SLFN11", "SLIRP", "SLIT2", "SLK", "SLMAP", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCC1", "SMARCC2", "SMARCD1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC5", "SMC6", "SMCHD1", "SMG1", "SMG5", "SMN1*", "SMNDC1", "SMS", "SMU1", "SND1", "SNRNP200", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPC", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNU13", "SNW1", "SNX1", "SNX17", "SNX19", "SNX2", "SNX27", "SNX3", "SNX5", "SNX6", "SNX9", "SOD2", "SON", "SORD", "SORT1", "SPAG9", "SPART", "SPATA5", "SPATA5L1", "SPC25", "SPECC1L", "SPEN", "SPNS1", "SPPL2A", "SPRYD4", "SPTAN1", "SPTBN1", "SPTLC1", "SPTLC2", "SQLE", "SRC", "SRCAP", "SREK1", "SRI", "SRM", "SRP54", "SRP68", "SRP72", "SRP9", "SRPK1", "SRPK2", "SRPRA", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF3", "SRSF4", "SRSF5", "SRSF7", "SRSF9", "SSB", "SSRP1", "STAG1", "STAG2", "STAM", "STAM2", "STAT1", "STAT3", "STAU1", "STAU2", "STIP1", "STK26", "STK3", "STK4", "STOM", "STOML2", "STRBP", "STRIP1", "STRN", "STUB1", "STX10", "STX12", "STX16", "STX18", "STX4", "STX7", "STX8", "STXBP4", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGP2", "SUGT1", "SUN1", "SUN2", "SUPT16H", "SUPT5H", "SUPT6H", "SUPV3L1", "SURF6", "SUZ12", "SV2A", "SYAP1", "SYMPK", "SYNCRIP", "SYNE1", "SYNE2", "SYNGR2", "SYNJ2BP", "TAB1", "TACC3", "TAF15", "TAF6", "TAGLN2", "TAP1", "TAP2", "TARBP1", "TARDBP", "TARS", "TARS2", "TARSL2", "TBC1D13", "TBC1D15", "TBC1D4", "TBC1D9B", "TBCB", "TBCD", "TBCE", "TBL1XR1", "TBL3", "TBRG4", "TCAF1", "TCEA1", "TCERG1", "TCOF1", "TDRKH", "TECR", "TELO2", "TERF2IP", "TES", "TEX10", "TFAM", "TFB1M", "TFCP2", "TFG", "TFIP11", "TFRC", "TGFBRAP1", "THADA", "THAP11", "THOC1", "THOC2", "THOC3", "THOP1", "THUMPD1", "THYN1", "TIA1", "TIAL1", "TIMM10B", "TIMM44", "TIMM50", "TIMM8B", "TJP1", "TJP2", "TKT", "TLCD1", "TLE3", "TLK2", "TLN1", "TMED10", "TMED2", "TMED7", "TMED9", "TMEM201", "TMEM205", "TMEM97", "TMLHE", "TMPO", "TMPO", "TMPPE", "TMTC3", "TMX1", "TMX2", "TMX3", "TNKS1BP1", "TNPO1", "TNPO2", "TNPO3", "TOE1", "TOP1", "TOP2A", "TOP2B", "TOPBP1", "TOX4", "TP53", "TP53BP1", "TP53BP2", "TPBG", "TPP1", "TPP2", "TPR", "TPT1", "TPX2", "TRA2A", "TRA2B", "TRAF2", "TRAP1", "TRAPPC11", "TRIM13", "TRIM21", "TRIM25", "TRIM26", "TRIM27", "TRIM28", "TRIM33", "TRIM4", "TRIO", "TRIP12", "TRIP13", "TRIP4", "TRMT1", "TRMT10C", "TRMT11", "TRMT1L", "TRMT2A", "TROVE2", "TRRAP", "TRUB1", "TSFM", "TSG101", "TSR1", "TST", "TTC28", "TTC4", "TTF2", "TTK", "TUBB", "TUBB2A", "TUBB2B", "TUBB3", "TUBB4A", "TUBB6", "TUBGCP2", "TUBGCP3", "TUFM", "TWF2", "TWNK", "TXNDC12", "TXNDC15", "TXNDC17", "TXNDC5", "TXNDC9", "TXNL1", "TXNRD1", "TYMS", "U2AF1", "U2AF2", "U2SURP", "UBA1", "UBA2", "UBA3", "UBA6", "UBAC1", "UBAP2L", "UBE2J1", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2O", "UBE2S", "UBE3A", "UBE3C", "UBE4A", "UBFD1", "UBLCP1", "UBQLN4", "UBR2", "UBR4", "UBR5", "UBTF", "UBXN1", "UBXN4", "UBXN7", "UCHL5", "UCK2", "UGDH", "UGGT1", "UGT8", "UHRF1", "UMPS", "UNC45A", "UPF1", "UPF2", "UPF3B", "UQCRC1", "UQCRC2", "UQCRFS1", "URB1", "URGCP", "UROD", "USO1", "USP10", "USP11", "USP14", "USP19", "USP24", "USP28", "USP36", "USP39", "USP47", "USP48", "USP5", "USP7", "USP9X", "UTP15", "UTP20", "UTP3", "UTRN", "VAMP7", "VAPA", "VAPB", "VARS1", "VARS2", "VAT1", "VCP", "VIM", "VIPAS39", "VIRMA", "VPS13A", "VPS13C", "VPS16", "VPS18", "VPS29", "VPS37B", "VPS4A", "VPS4B", "VPS50", "VPS51", "VPS53", "VRK1", "VRK3", "VTA1", "WAPL", "WARS", "WASHC4", "WBP2", "WDHD1", "WDR12", "WDR18", "WDR26", "WDR3", "WDR36", "WDR43", "WDR46", "WFS1", "WIZ", "WRNIP1", "XPNPEP1", "XPNPEP3", "XPO1", "XPO5", "XPO7", "XPOT", "XRCC1", "XRCC5", "XRCC6", "XRN2", "YARS", "YKT6", "YME1L1", "YOD1", "YTHDC1", "YTHDC2", "YTHDF2", "YTHDF3", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2", "ZC3H11A", "ZC3H14", "ZC3H15", "ZC3H18", "ZC3H4", "ZC3H7A", "ZC3HAV1", "ZCCHC11", "ZCCHC3", "ZCCHC8", "ZFR", "ZFYVE16", "ZMPSTE24", "ZMYM2", "ZMYM4", "ZNF281", "ZNF318", "ZNF326", "ZNF512B", "ZNF598", "ZNF622", "ZNF638", "ZPR1", "ZRANB2", "ZYX", "ZZEF1"], "leading_proteins": ["ABCB10", "ABCB6", "ABCB8", "ABCD3", "ACTN4", "ADD3", "AGPAT5", "AIFM1", "AKAP8", "AKAP8L", "ALG1", "ARHGAP17", "ASCC2", "ASNS", "ATAD3A", "ATP13A1", "ATP1A1", "ATP2A2", "ATP2B1", "ATP2C1", "ATP7A", "ATP7B", "AUP1", "BCKDK", "BRAP", "BRCA1", "BRD1", "BSG", "CALU", "CBX1", "CBX5", "CD47", "CELF1", "CERS2", "CETN2", "CIB1", "CIT", "CLCN3", "CLCN7", "CNNM4", "COLEC12", "COPS5", "COPS6", "CPNE1", "CPNE2", "CPNE8", "CPT2", "CRYZ", "CYB5B", "DDX50", "DHCR24", "DLD", "DLG1", "DNAJC16", "DNM2", "EBP", "EEF1B2", "EFCAB14", "EHD4", "EMD", "EPHA7", "ERAP1", "ERAP2", "ERGIC3", "ERLIN1", "ERLIN2", "ESYT2", "ETF1", "EXOC2", "EXOSC1", "FARP2", "FKBP10", "FKBP14", "FKBP7", "FLOT1", "FLOT2", "FOXRED1", "FUBP1", "FUCA2", "GALNS", "GALNT1", "GALNT4", "GDAP1", "GIGYF2", "GINS2", "GM2A", "GNG5", "GNPAT", "GPAM", "GRWD1", "HADHA", "HLA-A", "HLA-C", "HNRNPAB", "HNRNPF", "HNRNPH1", "HSD17B4", "HSDL2", "INA", "IPO7", "IPO8", "ITGB1", "KDM1B", "KIAA1147", "KMT2A", "KTN1", "LETM1", "LMAN2", "LMNA", "LMNB1", "LNPEP", "LPCAT1", "LPGAT1", "LRSAM1", "LTA4H", "MAN2A1", "MAPRE2", "MCM4", "MCU", "MFN1", "MFN2", "MFSD10", "MICU1", "MKRN2", "MORC2", "MPP1", "MPP2", "MPP6", "MPP7", "MRC2", "MRPS25", "MTX1", "MUT", "NCLN", "NEFL", "NEFM", "NIPSNAP2", "NPC1", "NRDC", "NSF", "NUB1", "NUCB1", "NUCB2", "NUP133", "OCLN", "OCRL", "OPA1", "P3H1", "P4HA1", "P4HA2", "PANK4", "PDK3", "PDLIM1", "PDZD8", "PGRMC2", "PHB", "PHB2", "PHKA1", "PIN1", "PITRM1", "PLD3", "PLXNB2", "PMPCA", "PNPLA6", "PPAT", "PPOX", "PRKAA1", "PRKAR1A", "PRKCB", "PSME3", "PSPC1", "PTPN23", "RACGAP1", "RAD23A", "RBBP7", "RBMXL1", "RCN2", "RHOT2", "ROCK1", "ROCK2", "RPS6KA3", "RTN2", "RTN3", "RTN4", "RTN4IP1", "S100A13", "SCO2", "SDF4", "SEC22B", "SEC23B", "SEC23IP", "SEL1L", "SFPQ", "SLC12A2", "SLC25A13", "SLC25A24", "SLC25A25", "SMARCC1", "SMARCC2", "SNX19", "SNX2", "SNX27", "SNX5", "SORD", "SPNS1", "SPTAN1", "STK4", "STOM", "STX10", "STX12", "STX7", "SUN2", "SV2A", "SYAP1", "SYNCRIP", "TAP1", "TAP2", "THOP1", "TIMM44", "TIMM50", "TIMM8B", "TLCD1", "TMED10", "TMED2", "TMED9", "TMPO", "TMX1", "TMX2", "TMX3", "TRIO", "TUBB", "TUBB2A", "TUBB2B", "TUBB3", "TUBB4A", "TXNDC15", "UBAC1", "UBQLN4", "UBXN1", "UQCRC2", "USP24", "VIM", "VIPAS39", "YKT6", "YME1L1", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAZ", "ZADH2", "ZC3H4"]} \ No newline at end of file diff --git a/interpro_family/advanced/idx2term.json b/interpro_family/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..53e469cf5e28b46b95f50be70f54024c8afc5b8d --- /dev/null +++ b/interpro_family/advanced/idx2term.json @@ -0,0 +1 @@ +{"0": "Mitochondrial carrier protein [IPR002067]", "1": "P-type ATPase [IPR001757]"} \ No newline at end of file diff --git a/interpro_family/advanced/plot_0.png b/interpro_family/advanced/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..6232a2e4080d32725061a274fd4562d6958b0adb --- /dev/null +++ b/interpro_family/advanced/plot_0.png 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[IPR002347]", "4": "Beta tubulin [IPR002453]", "5": "Tubulin [IPR000217]", "6": "Small GTPase [IPR001806]", "7": "14-3-3 protein [IPR000308]", "8": "Oxysterol-binding protein [IPR000648]", "9": "Sec1-like protein [IPR001619]"} \ No newline at end of file diff --git a/interpro_family/basic/plot_0.png b/interpro_family/basic/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..d0babe61988d871ad054a44370306d397095f27d --- /dev/null +++ b/interpro_family/basic/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:b3ec111a17b0ed1faf34fc06dbf2e36a33bf5499627086e99c179236a7fe1818 +size 142893 diff --git a/interpro_family/basic/plot_1.png b/interpro_family/basic/plot_1.png new file mode 100644 index 0000000000000000000000000000000000000000..00c0fae65d64c0aeaec99dee3562d554324e4112 --- /dev/null +++ b/interpro_family/basic/plot_1.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:1d75096743c5819f2b27a28897263d900bb8a7be36b93a76c2990a38744fc30d +size 135568 diff --git a/interpro_family/basic/plot_2.png b/interpro_family/basic/plot_2.png new file mode 100644 index 0000000000000000000000000000000000000000..47d6b5aa0b133654bbb7b3cadb35ad8cad360150 --- /dev/null +++ b/interpro_family/basic/plot_2.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:41234323d43b45ad16f92521c6664aa7cc8034a09b68f58b3baae08871552250 +size 129976 diff --git a/interpro_family/basic/plot_3.png b/interpro_family/basic/plot_3.png new file mode 100644 index 0000000000000000000000000000000000000000..4adafc247fc785d47532ecccbb64d8b7e8bcff5f --- /dev/null +++ b/interpro_family/basic/plot_3.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:1e0aaef586c89e70d1fa0e17928ef0290d0974a187b6433650a784072339528a +size 143193 diff --git a/interpro_family/basic/plot_4.png b/interpro_family/basic/plot_4.png new file mode 100644 index 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sha256:6070c7469eeab7eb70d6331906a49ecf792b9cf9694f56f0dde13863eaf497eb +size 143944 diff --git a/interpro_family/basic/plot_7.png b/interpro_family/basic/plot_7.png new file mode 100644 index 0000000000000000000000000000000000000000..766a90dae36c666d556f773905c72a96d02c94d2 --- /dev/null +++ b/interpro_family/basic/plot_7.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:65c787e4824fc148b4996d7d8e62784d72378a677f6cef2a53bb9f72b239f940 +size 133771 diff --git a/interpro_family/basic/plot_8.png b/interpro_family/basic/plot_8.png new file mode 100644 index 0000000000000000000000000000000000000000..b81a53a1f62428d75813965592dd740a4d0347de --- /dev/null +++ b/interpro_family/basic/plot_8.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:cdd0f7794475cc7b5cc12e278c33c2239eeecb1cd19fefd374d232c3eee04676 +size 139959 diff --git a/interpro_family/basic/plot_9.png b/interpro_family/basic/plot_9.png new file mode 100644 index 0000000000000000000000000000000000000000..c7f5414cb93172a9ca72fd38bfc707999a7367b3 --- /dev/null +++ b/interpro_family/basic/plot_9.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:a9a7f62024563fc2ec98529f78eb70e6f8b4bbe3925b21e0d40ffbdf527119d2 +size 127896 diff --git a/interpro_family/consensus.joblib b/interpro_family/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..698c87a75b81abdd5bda6ca65feb24408a5267a6 --- /dev/null +++ b/interpro_family/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:b930e3f76aba7177b52b667af8be37d70ab32add9324290e153e0457bfb977f0 +size 318785 diff --git a/interpro_family/df_merge.tsv b/interpro_family/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..73b3eb0727016d5e5b875d7ef0cf428a45a0ff48 --- /dev/null +++ b/interpro_family/df_merge.tsv @@ -0,0 +1,4 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Mitochondrial carrier protein [IPR002067] 12 13 3.0047644141901566 0.0026578662697289 5.686893203883495 11.07766990291262 0.8032246115450145 0.31892620527414 3.2338505495684404 1.5403272908315857 1.3918146051602212 0.3274613788058813 1.506015780795745e-09 1.0 1.0 0.0011814468070448 3.572406935806625e-10 +P-type ATPase [IPR001757] 7 8 2.548795892583177 0.0108095544235906 2.941747572815534 6.145631067961165 0.9567723497044874 0.2732808833570771 1.8358630293390923 1.459204245106796 1.2102525517005158 0.2943240638910574 0.0001926635075221 1.0 0.191600110602388 0.0152248647419399 0.0004867641084232 +Glutathione Transferase family [IPR040079] 3 9 2.045552928136509 0.0408003767343652 2.6650485436893203 9.45388349514563 0.453215617797485 0.4615521029697171 1.6850115229858122 1.256172900264393 0.947748980990547 0.2879961408071128 0.0019907060593634 0.0652597674910206 0.1265462710440741 0.0435926191526008 0.003721367796782 diff --git a/interpro_family/metrics.json b/interpro_family/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..f1af367834a04bd73695f7ef58d50a11f7cbeccb --- /dev/null +++ b/interpro_family/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3221, + "annotations_size": 2478, + "title": "Average number of proteins per term", + "value": 1.28773204196933 +} \ No newline at end of file diff --git a/interpro_family/paths.json b/interpro_family/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..91263b91550f80b0cfab54b7afedd31a4e6c78e9 --- /dev/null +++ b/interpro_family/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/interpro_family/fragment/C201/C201_val_log2fc"} \ No newline at end of file diff --git a/interpro_family/result.tsv b/interpro_family/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..ecf4fd4a2b0c134399f269da7fbe14db2bf1c6a2 --- /dev/null +++ b/interpro_family/result.tsv @@ -0,0 +1,130 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Mitochondrial carrier protein [IPR002067] 0.8098503740648405 3.0047644141901566 0.0026578662697289 0.9986327594477696 0.1681267359743798 13 P12236,Q6NUK1,Q96H78,Q9UJS0,Q9HC21,O75746,Q9BQT8,P05141,P16260,P53007,P12235,Q6KCM7 12 +P-type ATPase [IPR001757] 0.8291316526610572 2.548795892583177 0.0108095544235906 0.999999999997988 0.1681267359743798 8 P98194,Q9HD20,P20020,P05023,P16615,P35670,Q04656 7 +Glutathione Transferase family [IPR040079] 0.6950718830191712 2.0455529281365092 0.0408003767343652 1.0 0.1936413966591369 9 Q8TB36,Q9H7Z7,Q13505 3 +Type 1 protein exporter [IPR039421] 0.7293092719352926 1.9234343706735055 0.0544255212897191 1.0 0.2198966943085656 7 Q03519,Q9NRK6,Q03518,Q9NP58,O75027,Q9NUT2 6 +Major facilitator superfamily [IPR011701] 0.7851468655249164 1.8812431891505832 0.0599388451240114 1.0 0.2285601904631143 5 Q9H2V7,Q96ES6,Q7L0J3 3 +Syntaxin [IPR045242] 0.7414758323165882 1.8480551814467412 0.0645943604875105 1.0 0.23723402774303 6 Q86Y82,O15400,O60499 3 +Eukaryotic porin/Tom40 [IPR027246] 0.8765064247950722 1.8230980103737748 0.0682885478955461 1.0 0.2413643189668657 4 P21796,P45880 2 +Proteasome B-type subunit [IPR023333] 0.7027061634480867 1.794242231459758 0.0727745141824287 1.0 0.2474936744696438 7 P49721 1 +Tetraspanin, animals [IPR000301] 0.990990990990991 1.7260687507912102 0.0843350449000084 1.0 0.266899414127996 2 O43657 1 +Tetraspanin/Peripherin [IPR018499] 0.990990990990991 1.7260687507912102 0.0843350449000084 1.0 0.266899414127996 2 O43657 1 +Haem oxygenase [IPR002051] 0.9872631251941596 1.7108426148126807 0.0871101703964414 1.0 0.2712689668265163 2 P09601 1 +Haem oxygenase-like [IPR016053] 0.9872631251941596 1.7108426148126807 0.0871101703964414 1.0 0.2712689668265163 2 P09601 1 +Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase [IPR001930] 0.7085535341000001 1.6936233050770766 0.0903368866443727 1.0 0.2756832575181721 6 Q9NZ08,Q6P179,P09960,Q9UIQ6 4 +Cytochrome P450 [IPR001128] 0.9826032929481194 1.6918005263839195 0.0906840132117754 1.0 0.2758123104232832 2 Q6UW02 1 +Porin, eukaryotic type [IPR001925] 0.9770043505282772 1.6808311781151382 0.0927957108166654 1.0 0.2800825473857455 3 P21796,P45880 2 +Nucleobindin [IPR040250] 0.9760795278036644 1.6651255595140937 0.0958877083871381 1.0 0.2854234697569202 2 P80303 1 +Membrane insertase YidC/ALB3/OXA1/COX18 [IPR001708] 0.9757688723205964 1.6638548917411764 0.096141431294991 1.0 0.2856576339915922 2 Q8N8Q8 1 +Mitochondrial carrier UCP-like [IPR002030] 0.967381174277724 1.629533730752725 0.1032000802821184 1.0 0.2984011656232083 2 Q9H2D1 1 +Short-chain dehydrogenase/reductase SDR [IPR002347] 0.5069299307534783 1.6272045830008448 0.1036936547145357 1.0 0.29947887690282 20 Q3SXM5,Q9Y394,P51659,Q8NBN7,Q9BY49,Q6IAN0,Q8NBQ5,Q53GQ0,Q96LJ7,Q06136,Q6YN16 11 +V-type ATPase, V0 complex, 116kDa subunit family [IPR002490] 0.9642746194470329 1.616816428442161 0.1059179121265376 1.0 0.3012381454303591 2 Q93050 1 +ATPase, V0 complex, subunit 116kDa, eukaryotic [IPR026028] 0.9642746194470329 1.616816428442161 0.1059179121265376 1.0 0.3012381454303591 2 Q93050 1 +Sulfotransferase [IPR005331] 0.954954954954954 1.578649810028867 0.1144164028970808 1.0 0.311638443852639 2 Q8NCH0 1 +CD36 family [IPR002159] 0.9509164336750526 1.562105628866055 0.118263107078314 1.0 0.3161337425459138 2 Q14108 1 +Cytochrome c oxidase subunit VII [IPR039297] 0.9487418452935664 1.5531962707217488 0.1203762520063844 1.0 0.3185304793955543 2 P14406 1 +Cytochrome c oxidase subunit VIIa, metazoa [IPR003177] 0.9487418452935664 1.5531962707217488 0.1203762520063844 1.0 0.3185304793955543 2 P14406 1 +MICOS complex subunit MIC26/MIC27 [IPR019166] 0.9456352904628752 1.5404677448289197 0.1234463793066109 1.0 0.3226794598331033 2 Q9BUR5 1 +MICOS complex subunit MIC26/MIC27, animal [IPR033182] 0.9456352904628752 1.5404677448289197 0.1234463793066109 1.0 0.3226794598331033 2 Q9BUR5 1 +Lysosome-associated membrane glycoprotein [IPR002000] 0.9394221808014892 1.515008900411541 0.1297701501602923 1.0 0.3328886460633586 2 P13473 1 +Aminopeptidase N-type [IPR034016] 0.7976375505128835 1.5004651742495372 0.133493948070454 1.0 0.3382536635937874 4 Q9NZ08,Q6P179,Q9UIQ6 3 +Chloride channel, voltage gated [IPR001807] 0.9316557937247584 1.4831856995812944 0.1380250795744433 1.0 0.343515576520523 2 P51798 1 +Transmembrane emp24 domain-containing protein [IPR015720] 0.7932856698787563 1.4824888725839285 0.1382102622239553 1.0 0.343515576520523 4 P49755,Q9BVK6,Q15363 3 +Peptidase S10, serine carboxypeptidase [IPR001563] 0.9220012430080758 1.469407284116657 0.1417223528000428 1.0 0.3481612404974789 3 Q9HB40,P10619 2 +Importin beta family [IPR040122] 0.6609110298921375 1.466468983611439 0.1425205650297516 1.0 0.3486337217608337 6 O60518,Q8TEX9,O14787,Q92973 4 +Cleft lip and palate transmembrane protein 1-like protein [IPR030434] 0.9257533395464392 1.459003693490548 0.1445640911170691 1.0 0.3515927210563451 2 O96005 1 +Cleft lip and palate transmembrane 1 [IPR008429] 0.9257533395464392 1.459003693490548 0.1445640911170691 1.0 0.3515927210563451 2 O96005 1 +Graves disease carrier protein [IPR002167] 0.909881914232439 1.422683183800244 0.1548280176075169 1.0 0.3638261846375005 3 Q6KCM7,P16260 2 +Mpv17/PMP22 [IPR007248] 0.899005593536359 1.380739488170962 0.1673590751132507 1.0 0.3781137395121368 3 P39210,Q567V2 2 +AmpG-like permease/Acetyl-coenzyme A transporter 1 [IPR004752] 0.904628766697728 1.372528390890413 0.1698990069035957 1.0 0.380159181247039 2 O00400 1 +P-type ATPase, subfamily IB [IPR027256] 0.9015222118670334 1.3598263227276226 0.1738848904852505 1.0 0.3838352933816393 2 P35670 1 +TB2/DP1/HVA22-related protein [IPR004345] 0.8887853370611942 1.307807571536981 0.1909385854503447 1.0 0.4071822846350724 2 Q9H6H4 1 +Copper chaperone SCO1/SenC [IPR003782] 0.8856787822305043 1.295137310437601 0.1952728659978269 1.0 0.4121687921146635 2 O43819 1 +Synthesis of cytochrome c oxidase, Sco1/Sco2 [IPR017276] 0.8856787822305043 1.295137310437601 0.1952728659978269 1.0 0.4121687921146635 2 O43819 1 +Guanine nucleotide binding protein (G-protein), alpha subunit [IPR001019] 0.6492103556114117 1.269373185112599 0.2043079953043509 1.0 0.4222478835397679 5 P50148,P04899 2 +SCAMP [IPR007273] 0.7365253792072017 1.2471496290886797 0.2123426383466591 1.0 0.4308304582465372 4 O14828,O15127 2 +Nucleosome assembly protein (NAP) [IPR002164] 0.8592293349906737 1.227503388540878 0.2196334490025562 1.0 0.4397443836990735 3 Q01105,Q99733 2 +Derlin [IPR007599] 0.868903386144759 1.226868041892708 0.2198721918495367 1.0 0.4397443836990735 2 Q9GZP9 1 +ATPase family AAA domain-containing protein 3 [IPR039188] 0.8648648648648607 1.210477275179035 0.2260958055873434 1.0 0.4439504011453542 2 Q9NVI7 1 +Acyltransferase ChoActase/COT/CPT [IPR000542] 0.8642435538987245 1.207957361603152 0.2270636635974381 1.0 0.4449364589010052 2 P23786 1 +Phosphatidyl serine synthase [IPR004277] 0.8633115874495159 1.204178391527471 0.2285206359656273 1.0 0.4464337646337097 2 Q9BVG9 1 +Ergosterol biosynthesis ERG4/ERG24 [IPR001171] 0.8623796210003052 1.2004005173746652 0.2299838280439421 1.0 0.4480345329346608 2 Q14739 1 +Ancient conserved domain protein family [IPR045095] 0.8608263435849619 1.1941065437798413 0.2324362938204904 1.0 0.4508011989005426 2 Q6P4Q7 1 +Tumour protein D52 [IPR007327] 0.8595837216526812 1.1890736473622914 0.2344106873144085 1.0 0.4524510902689113 2 P55327 1 +ABC transporter Tap-like [IPR013305] 0.8570984777881325 1.1790141223922466 0.2383925524055237 1.0 0.456167370548948 2 Q03519 1 +ADP/ATP carrier protein, eukaryotic type [IPR002113] 0.8380981976382782 1.146415218387549 0.2516233887668784 1.0 0.4730825169683799 3 P12235,P12236 2 +Mitofusin family [IPR027094] 0.8487107797452562 1.1451291202457363 0.2521556742428403 1.0 0.4733649702831503 2 Q8IWA4 1 +Peptidase M3A/M3B [IPR045090] 0.8333129830004438 1.1281053567866146 0.2592754271235669 1.0 0.4823457270361853 3 P52888 1 +Prenylated rab acceptor PRA1 [IPR004895] 0.8424976700838702 1.1201007435188413 0.2626708338362302 1.0 0.4861077865916196 2 O60831 1 +Prohibitin [IPR000163] 0.8421870146008001 1.1188510469857862 0.2632036900132801 1.0 0.4867304058603792 2 Q99623 1 +Anoctamin [IPR007632] 0.8347312830071391 1.0889109402621229 0.2761931613055668 1.0 0.4998228389160696 2 Q9NW15 1 +Histidine phosphatase superfamily, clade-2 [IPR000560] 0.8190334011791729 1.07361707680716 0.2829943406769915 1.0 0.5069224978619501 3 P11117 1 +Prolyl 4-hydroxylase [IPR045054] 0.8278968623796189 1.0615607872927844 0.2884351232450184 1.0 0.5135338680782238 2 O15460 1 +P-type ATPase, subfamily IIB [IPR006408] 0.8275862068965523 1.0603199010819822 0.2889990884396312 1.0 0.5136997379852116 2 P20020 1 +Transmembrane protein GPR107/GPR108-like [IPR009637] 0.8054692355500065 1.022109673605872 0.3067289951908734 1.0 0.5322650210665155 3 Q5VW38,Q8NBN3 2 +Peptidase A22B, signal peptide peptidase [IPR007369] 0.8148493320907021 1.00963140241674 0.3126719188258458 1.0 0.5389569169989611 2 Q8TCT8 1 +Presenilin/signal peptide peptidase [IPR006639] 0.8148493320907021 1.00963140241674 0.3126719188258458 1.0 0.5389569169989611 2 Q8TCT8 1 +Sorting nexin-5/6/32 [IPR014637] 0.8136067101584303 1.004707018773951 0.31503794746662 1.0 0.5406260622037982 2 Q9Y5X3 1 +Endoplasmic reticulum vesicle transporter [IPR045888] 0.80552966759862 0.97279714476193 0.330654132049617 1.0 0.5547467428699736 2 Q9Y282 1 +Sphingosine N-acyltransferase Lag1/Lac1-like [IPR016439] 0.8045977011494139 0.969126684083335 0.3324819854540224 1.0 0.5563067926772907 2 Q96G23 1 +Glycerol-3-phosphate O-acyltransferase/Dihydroxyacetone phosphate acyltransferase [IPR022284] 0.8042870456663436 0.9679037425660614 0.3330924450440402 1.0 0.5569521449521806 2 Q9HCL2 1 +Small GTPase Rho [IPR003578] 0.582273559955302 0.9625532045731906 0.335771790891648 1.0 0.5595443832074671 5 Q8IXI1 1 +Beta tubulin [IPR002453] 0.5480559875583171 0.918693609223736 0.358255853478598 1.0 0.582171504373089 6 Q13509,P07437,P04350,Q9BVA1,Q13885 5 +Tubulin [IPR000217] 0.5480559875583171 0.918693609223736 0.358255853478598 1.0 0.582171504373089 6 Q13509,P07437,P04350,Q9BVA1,Q13885 5 +Erlin1/2 [IPR033294] 0.7896862379620966 0.9107520252210396 0.3624260453789414 1.0 0.5854574579198284 2 O94905 1 +Proteasome activator PA28 [IPR009077] 0.7704316739641228 0.8906083351247229 0.3731393260378355 1.0 0.595415648283465 3 P61289 1 +Peptidase M24, methionine aminopeptidase [IPR001714] 0.784405094749919 0.8902496272912143 0.3733318623910691 1.0 0.595415648283465 2 P53582 1 +Polyprenyl synthetase [IPR000092] 0.7822305063684338 0.8818357324054665 0.377865645391491 1.0 0.598765676931215 2 P14324 1 +Long-chain fatty acid CoA synthetase, eukaryotic [IPR045311] 0.7816091954022857 0.8794348762449203 0.3791655290033624 1.0 0.5993199233660548 2 Q9UKU0 1 +Translin family [IPR002848] 0.7757067412239835 0.8566978349464635 0.391611900187875 1.0 0.6114771825239788 2 Q99598 1 +G-protein alpha subunit, group I [IPR001408] 0.7601820020576755 0.8526812331730992 0.3938361008130999 1.0 0.6125374517405476 3 P04899 1 +Proteasome, subunit alpha/beta [IPR001353] 0.4323495446317356 0.8516165732224348 0.3944269379987266 1.0 0.6125374517405476 14 P49721 1 +Flotillin family [IPR027705] 0.7726001863932819 0.8447843351695269 0.3982312623090114 1.0 0.6159906791521412 2 O75955 1 +SUN domain-containing protein 1-5 [IPR045119] 0.7716682199440744 0.8412177002558303 0.4002259862914754 1.0 0.6183235915578379 2 Q9UH99 1 +Stomatin/HflK/HflC family [IPR001972] 0.769804287045653 0.8340948965980857 0.4042275107359139 1.0 0.6206169588622024 2 P27105 1 +Tricarboxylate/iron carrier [IPR004686] 0.7546064109966508 0.8321744419415062 0.4053104878870956 1.0 0.6207412787294333 3 Q6P4A7 1 +SLC12A transporter family [IPR004842] 0.7604846225535835 0.7986985477140612 0.4244652290957045 1.0 0.6370834874010635 2 P55011 1 +Peptidase, FtsH [IPR005936] 0.7576887232059635 0.7881535767310349 0.4306068797053526 1.0 0.6420659581904722 2 Q96TA2 1 +Synaptobrevin [IPR001388] 0.7536502019260612 0.7729852683798868 0.4395310991299284 1.0 0.6510209585439106 2 O75396 1 +Membrane bound O-acyl transferase, MBOAT [IPR004299] 0.7499223361292238 0.759052329374483 0.4478212540313335 1.0 0.6577127767343616 2 Q96N66 1 +Prefoldin alpha-like [IPR004127] 0.7471264367816035 0.7486472112613562 0.4540698686184345 1.0 0.6632780902416238 2 Q99471 1 +UV excision repair protein Rad23 [IPR004806] 0.7468157812985301 0.7474934940336919 0.4547657285393538 1.0 0.6632780902416238 2 P54725 1 +MCU family [IPR039055] 0.7415346380863592 0.7279557813458356 0.4666406550305286 1.0 0.6728416167826604 2 Q8NE86 1 +Peptidase C13, legumain [IPR001096] 0.7378067722895214 0.7142526330949762 0.4750709761073142 1.0 0.6798401314111642 2 Q92643 1 +Microtubule-associated protein RP/EB [IPR027328] 0.7247592420006196 0.6669032182584577 0.5048339551430552 1.0 0.7028987383854364 2 Q15555 1 +Vang-like protein [IPR009539] 0.7213420316868533 0.6546683088341159 0.5126813335472411 1.0 0.7081518085451859 2 Q8TAA9 1 +Endoplasmic reticulum oxidoreductin 1 [IPR007266] 0.7173035104069541 0.6403027281491994 0.5219758074580092 1.0 0.7126959868092949 2 Q96HE7 1 +ClpA/B family [IPR001270] 0.7169928549238764 0.6392019807385394 0.5226915437360236 1.0 0.7128396507308016 2 Q15645 1 +TAF15/EWS/TLS family [IPR034870] 0.6976382846488571 0.6291571840015112 0.5292461564016926 1.0 0.7158131911408375 3 Q92804,Q01844 2 +A-kinase anchoring protein 95 (AKAP95) [IPR007071] 0.6920447482908711 0.6100129029319613 0.5418532603186823 1.0 0.7238341666143907 3 Q9ULX6,O43823 2 +Phosphorylase kinase alpha/beta subunit [IPR008734] 0.7076731904318043 0.6064751727640415 0.5441992638136877 1.0 0.7248492785806633 2 P46020 1 +Alpha-L-fucosidase, metazoa-type [IPR016286] 0.706119913016455 0.6010779118300005 0.5477880944090938 1.0 0.7248492785806633 2 Q9BTY2 1 +Glycoside hydrolase, family 29 [IPR000933] 0.706119913016455 0.6010779118300005 0.5477880944090938 1.0 0.7248492785806633 2 Q9BTY2 1 +G-protein, gamma subunit [IPR001770] 0.7027027027026913 0.5892635231708985 0.5556845102594972 1.0 0.7293359197155901 2 P63218 1 +Kinesin light chain [IPR002151] 0.6716371543957645 0.4859520700677612 0.6270011490129812 1.0 0.7706901937192946 2 Q9NSK0 1 +NSF attachment protein [IPR000744] 0.6710158434296298 0.4839671079485724 0.6284092126461625 1.0 0.7708901133352429 2 Q99747 1 +Small GTPase [IPR001806] 0.3384355427461161 0.4732805546303822 0.636013033348624 1.0 0.7750854400169428 30 P61026,Q969Q5,Q15382,P84095,Q8IXI1,P62820,P61019,Q9BZG1 8 +KH domain-containing BBP-like [IPR045071] 0.5374572583152092 0.4577664225283993 0.6471202615963749 1.0 0.782990238396395 4 Q96PU8,Q07666,O75525 3 +Dynamin [IPR022812] 0.6065385858916948 0.3433919551009239 0.7313036109087283 1.0 0.8238402232224104 3 O60313 1 +Clathrin light chain [IPR000996] 0.6197576887231984 0.3331128909597213 0.7390490689842366 1.0 0.8255859990780587 2 P09496 1 +Mrp/NBP35 ATP-binding protein [IPR019591] 0.6169617893755746 0.3256868725671958 0.7446612773513661 1.0 0.8260779498896325 2 Q9Y5Y2 1 +Flagellum site-determining protein YlxH/ Fe-S cluster assembling factor NBP35 [IPR033756] 0.6169617893755746 0.3256868725671958 0.7446612773513661 1.0 0.8260779498896325 2 Q9Y5Y2 1 +14-3-3 protein [IPR000308] 0.3996889580093333 0.2524292623061593 0.8007092842659191 1.0 0.8519354256809565 6 P62258,Q04917,P61981,P31946,P63104 5 +HnRNP R/Q splicing factor [IPR006535] 0.5705407085146177 0.2501748916131475 0.80245210157016 1.0 0.8523672500796907 3 A0AV96,O60506 2 +Vacuolar protein-sorting protein Bro1-like [IPR045251] 0.586206896551714 0.2501245398995789 0.8024910389168356 1.0 0.8523672500796907 2 Q9H3S7 1 +Heterogeneous nuclear ribonucleoprotein C [IPR017347] 0.5762659210935004 0.2282017730609737 0.8194893831013061 1.0 0.8636066092809808 2 Q9UKM9 1 +Vesicle-associated membrane-protein-associated protein [IPR016763] 0.5598011804908235 0.1946850469332185 0.8456395187415922 1.0 0.879429027025299 2 Q9P0L0 1 +Vacuolar protein sorting-associated protein 33 [IPR027121] 0.5563839701770612 0.1881701805888756 0.8507432473552723 1.0 0.8812688480437822 2 Q9H267 1 +PDK/BCKDK protein kinase [IPR039028] 0.5015537600994503 0.1123489556247297 0.9105467265033436 1.0 0.927769238600035 3 O14874,Q15120 2 +Mini-chromosome maintenance protein [IPR031327] 0.3560457359709734 0.1015832519873267 0.9190874736499977 1.0 0.9345501681184628 6 P33991 1 +Oxysterol-binding protein [IPR000648] 0.3530326594090068 0.0924349787993509 0.9263524493170116 1.0 0.9411649731068288 6 P22059,Q9BZF3,Q9BXW6,Q9BZF1,Q96SU4 5 +CPSF6/7 family [IPR034772] 0.4843118981049904 0.085599537373867 0.9317847662334584 1.0 0.9462961683305368 2 Q8N684 1 +Adaptor protein complex, sigma subunit [IPR016635] 0.4408201304753026 0.0524684469112967 0.958155436408094 1.0 0.9679205753849396 2 P53680 1 +Plakophilin/Delta catenin [IPR028435] 0.4386455420938152 0.0512716989431442 0.959109019405332 1.0 0.9681532077030438 2 O00192 1 +Copine [IPR045052] 0.3748834317687346 0.0387498639358488 0.9690898175666977 1.0 0.9769750072946608 4 Q96FN4,Q86YQ8,Q99829 3 +Macrophage migration inhibitory factor [IPR001398] 0.4041627834731285 0.0369324636806634 0.9705388551230087 1.0 0.9777450632128318 2 P14174 1 +Sec1-like protein [IPR001619] 0.327629122588672 0.0368021009975303 0.9706427988311406 1.0 0.9777450632128318 7 Q8WVM8,O00186,Q96AX1,Q15833,Q9H267,Q8WU76 6 +FAM98 [IPR018797] 0.3932898415656994 0.033934871430243 0.9729290858129216 1.0 0.97925193933567 2 Q52LJ0 1 +Acidic leucine-rich nuclear phosphoprotein 32 [IPR045081] 0.4285270354257449 0.0277137067767606 0.9778904914760806 1.0 0.9830477232769688 3 P39687,Q92688 2 +Protein transport protein Sec23 [IPR037364] 0.3460702081391768 0.0265512925985615 0.9788176224229588 1.0 0.983580725208472 2 Q15437 1 +ELL/occludin family [IPR031176] 0.3289841565703686 0.0253723337695753 0.979757978455196 1.0 0.9841131285238186 2 Q16625 1 diff --git a/interpro_family/selections.json b/interpro_family/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..2a98cf7dde89b9890ee8764ae159607c44e99a89 --- /dev/null +++ b/interpro_family/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["(Uracil-5)-methyltransferase family [IPR010280]", "-alpha-acetyltransferase 35, NatC auxiliary subunit [IPR007244]", "1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase, eukaryotes [IPR027496]", "1-Cys peroxiredoxin [IPR045020]", "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [IPR028380]", "14-3-3 protein [IPR000308]", "14-3-3 theta [IPR042584]", "18S rRNA (guanine(1575)-N(7))-methyltransferase Bud23-like [IPR039769]", "2-amino-3-ketobutyrate coenzyme A ligase [IPR011282]", "2-deoxynucleoside 5-phosphate N-hydrolase 1, DNPH1 [IPR028607]", "2-oxoglutarate and iron-dependent oxygenase domain-containing protein 3 [IPR039210]", "2-oxoglutarate dehydrogenase E1 component [IPR011603]", "2-phosphoglycolate phosphatase, eukaryotic [IPR006349]", "26S Proteasome non-ATPase regulatory subunit 1 [IPR035266]", "26S Proteasome non-ATPase regulatory subunit 11 [IPR035295]", "26S Proteasome non-ATPase regulatory subunit 12 [IPR035297]", "26S Proteasome non-ATPase regulatory subunit 12/COP9 signalosome complex subunit 4 [IPR040134]", "26S Proteasome non-ATPase regulatory subunit 13 [IPR035298]", "26S Proteasome non-ATPase regulatory subunit 14 [IPR035299]", "26S Proteasome non-ATPase regulatory subunit 6 [IPR035268]", "26S Proteasome non-ATPase regulatory subunit 7/8 [IPR033858]", "26S Proteasome regulatory subunit 4 [IPR035244]", "26S Proteasome regulatory subunit 6A [IPR035254]", "26S Proteasome regulatory subunit 6B [IPR035256]", "26S Proteasome regulatory subunit 7 [IPR035245]", "26S proteasome non-ATPase regulatory subunit 10-like [IPR039334]", "26S proteasome non-ATPase regulatory subunit 3 [IPR035267]", "26S proteasome non-ATPase regulatory subunit Rpn12 [IPR006746]", "26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit [IPR016643]", "26S proteasome regulatory complex, non-ATPase subcomplex, Rpn2/Psmd1 subunit [IPR016642]", "26S proteasome regulatory subunit 10B [IPR035263]", "26S proteasome regulatory subunit P45-like [IPR005937]", "26S proteasome regulatory subunit Rpn7/COP9 signalosome complex subunit 1 [IPR019585]", "28S ribosomal protein S25, mitochondrial [IPR040049]", "28S ribosomal protein S27, mitochondrial [IPR019266]", "28kDa heat- and acid-stable phosphoprotein [IPR039876]", "3'-5' RNA helicase YTHDC2-like [IPR031083]", "3-hydroxyacyl-CoA dehydrogenase [IPR022694]", "3-hydroxyisobutyrate dehydrogenase [IPR011548]", "3-hydroxyisobutyrate dehydrogenase-related [IPR015815]", "3-keto-steroid reductase [IPR042829]", "3-ketodihydrosphingosine reductase KDSR-like [IPR045022]", "3-oxo-5-alpha-steroid 4-dehydrogenase/very-long-chain enoyl-CoA reductase [IPR039357]", "39S ribosomal protein L40, mitochondrial [IPR039145]", "39S ribosomal protein L43/54S ribosomal protein L51 [IPR039927]", "39S ribosomal protein L46, mitochondrial [IPR040008]", "40S Ribosomal protein S10 [IPR037447]", "40S ribosomal protein S1/3, eukaryotes [IPR027500]", "40S ribosomal protein S29/30S ribosomal protein S14 type Z [IPR039744]", "40S ribosomal protein SA [IPR027504]", "4F2 cell-surface antigen heavy chain [IPR042280]", "5'-3' exoribonuclease [IPR027073]", "5'-3' exoribonuclease type 2 [IPR017151]", "5'-AMP-activated protein kinase subunit gamma-1 [IPR039166]", "5-formyltetrahydrofolate cyclo-ligase [IPR002698]", "5-lipoxygenase-activating protein [IPR001446]", "50S ribosomal protein L18Ae/60S ribosomal protein L20 and L18a [IPR028877]", "6-Phosphogluconolactonase [IPR039104]", "6-phosphogluconate dehydrogenase [IPR006183]", "6-phosphogluconate dehydrogenase, decarboxylating [IPR006113]", "60S acidic ribosomal protein P0 [IPR030670]", "60S ribosomal protein L18a/ L20, eukaryotes [IPR021138]", "60S ribosomal protein L19 [IPR039547]", "60S ribosomal protein L35 [IPR045059]", "60S ribosomal protein L6E [IPR000915]", "60kDa SS-A/Ro ribonucleoprotein [IPR040322]", "A-kinase anchor protein 9/Pericentrin [IPR028745]", "A-kinase anchoring protein 95 (AKAP95) [IPR007071]", "A1 cistron-splicing factor, AAR2 [IPR007946]", "AAA ATPase, CDC48 family [IPR005938]", "ABC transporter Tap-like [IPR013305]", "ADF/Cofilin [IPR017904]", "ADP-ribosylation factor 1-5 [IPR045872]", "ADP-ribosylation factor 6 [IPR041838]", "ADP-ribosylation factor-like protein 2 [IPR045873]", "ADP-ribosylation factor-like protein 2/3 [IPR044612]", "ADP-ribosylation factor-like protein 6-interacting protein 1 [IPR033301]", "ADP-ribosylation factor-like protein 8A/8B [IPR044154]", "ADP-specific phosphofructokinase/glucokinase [IPR007666]", "ADP/ATP carrier protein, eukaryotic type [IPR002113]", "AH receptor-interacting protein [IPR031208]", "AIP/AIPL1 [IPR039663]", "ALG11 mannosyltransferase [IPR038013]", "AP complex subunit beta [IPR026739]", "AP endonuclease 1 [IPR004808]", "AP-1 complex subunit sigma [IPR044733]", "AP-1/2/4 complex subunit beta [IPR016342]", "AP-2 complex subunit sigma [IPR027156]", "AP-3 complex subunit beta [IPR026740]", "ARMET-like [IPR045333]", "AT-rich interactive domain-containing protein 3 [IPR045147]", "ATP synthase membrane subunit K [IPR009125]", "ATP synthase, F0 complex, subunit B [IPR013837]", "ATP synthase, F0 complex, subunit B/MI25 [IPR008688]", "ATP synthase, F0 complex, subunit D, mitochondrial [IPR008689]", "ATP synthase, F0 complex, subunit E, mitochondrial [IPR008386]", "ATP synthase, F0 complex, subunit G, mitochondrial [IPR006808]", "ATP synthase, F1 complex, alpha subunit [IPR005294]", "ATP synthase, F1 complex, beta subunit [IPR005722]", "ATP synthase, F1 complex, gamma subunit [IPR000131]", "ATP-binding cassette sub-family C member 4 [IPR030240]", "ATP-binding cassette subfamily B member 10-like [IPR030260]", "ATP-citrate synthase [IPR014608]", "ATP-dependent 6-phosphofructokinase [IPR022953]", "ATP-dependent 6-phosphofructokinase, eukaryotic-type [IPR009161]", "ATP-dependent 6-phosphofructokinase, vertebrate-type [IPR041914]", "ATP-dependent Clp protease proteolytic subunit [IPR001907]", "ATP-dependent RNA helicase DHX29 [IPR034730]", "ATP-dependent RNA helicase Ski2-like [IPR016438]", "ATP-dependent helicase Rad3/Chl1-like [IPR013020]", "ATP11 [IPR010591]", "ATP:cob(I)alamin adenosyltransferase, PduO-type [IPR029499]", "ATP:guanido phosphotransferase [IPR000749]", "ATPase ARIP4-like [IPR044574]", "ATPase family AAA domain-containing protein 2 [IPR031252]", "ATPase family AAA domain-containing protein 3 [IPR039188]", "ATPase family AAA domain-containing protein ATAD2-like [IPR045199]", "ATPase, OSCP/delta subunit [IPR000711]", "ATPase, V0 complex, c/d subunit [IPR002843]", "ATPase, V0 complex, subunit 116kDa, eukaryotic [IPR026028]", "ATPase, V0 complex, subunit d [IPR016727]", "ATPase, V1 complex, subunit A [IPR005725]", "ATPase, V1 complex, subunit B [IPR005723]", "ATPase, V1 complex, subunit C [IPR004907]", "ATPase, V1 complex, subunit D [IPR002699]", "ATPase, V1 complex, subunit H [IPR004908]", "ATPase, vacuolar ER assembly factor, Vma12 [IPR021013]", "ATR-interacting protein [IPR033349]", "Abr/Bcr [IPR037769]", "Acetyl-coenzyme A transporter 1-like [IPR024371]", "Acid ceramidase-like [IPR016699]", "Acidic leucine-rich nuclear phosphoprotein 32 [IPR045081]", "Acireductone dioxygenase ARD family [IPR004313]", "Aconitase, mitochondrial-like [IPR006248]", "Aconitase/Iron-responsive element-binding protein 2 [IPR006249]", "Actin family [IPR004000]", "Actin-histidine N-methyltransferase SETD3 [IPR025785]", "Actin-related protein 2/3 complex subunit 1 [IPR017383]", "Actin-related protein 2/3 complex subunit 1A [IPR030140]", "Actin-related protein 2/3 complex subunit 2 [IPR007188]", "Actin-related protein 2/3 complex subunit 3 [IPR007204]", "Actin-related protein 2/3 complex subunit 4 [IPR008384]", "Actin-related protein 3 [IPR015623]", "Actin-related protein 8/Plant actin-related protein 9 [IPR027668]", "Activating signal cointegrator 1-like [IPR039128]", "Activator of 90kDa heat shock protein ATPase-like [IPR039981]", "Activator of Hsp90 ATPase homologue 1-like [IPR013538]", "Active zone protein ELKS [IPR019323]", "Activity-dependent neuroprotector homeobox protein [IPR038861]", "Acyl-CoA desaturase [IPR015876]", "Acyl-CoA oxidase [IPR012258]", "Acyl-CoA thioesterase [IPR003703]", "Acyl-CoA-binding domain-containing protein 5 [IPR016347]", "Acyl-coenzyme A thioesterase 13 [IPR039298]", "Acylneuraminate cytidylyltransferase [IPR003329]", "Acyltransferase ChoActase/COT/CPT [IPR000542]", "Adaptor protein complex AP-1, gamma subunit [IPR017107]", "Adaptor protein complex AP-2, alpha subunit [IPR017104]", "Adaptor protein complex AP-3, delta subunit [IPR017105]", "Adaptor protein complex, sigma subunit [IPR016635]", "Adenine phosphoribosyl transferase [IPR005764]", "Adenosine deaminase [IPR028893]", "Adenosine kinase [IPR001805]", "Adenosine/adenine deaminase [IPR006330]", "Adenosylhomocysteinase-like [IPR000043]", "Adenylate cyclase-associated CAP [IPR001837]", "Adenylate kinase 2 [IPR028587]", "Adenylate kinase 3/4, mitochondrial [IPR028586]", "Adenylate kinase 4, mitochondrial [IPR028585]", "Adenylate kinase isoenzyme 1 [IPR028582]", "Adenylate kinase isoenzyme 6 [IPR020618]", "Adenylate kinase subfamily [IPR006259]", "Adenylate kinase, isozyme 1/5 [IPR006267]", "Adenylate kinase/UMP-CMP kinase [IPR000850]", "Adenylosuccinate lyase [IPR004769]", "Adenylosuccinate synthetase [IPR001114]", "Adenylosuccinate synthetase isozyme 2, chordates [IPR027529]", "Adenylyl cyclase-associated protein CAP1 [IPR028415]", "Adenylyl-sulfate kinase [IPR002891]", "AdoMet-dependent rRNA methyltransferase Spb1-like [IPR028589]", "Aladin [IPR045139]", "Alanine-tRNA ligase, class IIc [IPR002318]", "Alanine-tRNA ligase, eukaryota/bacteria [IPR023033]", "Alcohol dehydrogenase class III [IPR014183]", "Aldehyde dehydrogenase NAD(P)-dependent [IPR012394]", "Aldehyde dehydrogenase [IPR011408]", "Aldehyde dehydrogenase family 7 member A1-like [IPR044638]", "Aldo-keto reductase [IPR020471]", "Aldo-keto reductase family 1 member A1 [IPR044481]", "Aldose 1-/Glucose-6-phosphate 1-epimerase [IPR008183]", "Aldose 1-epimerase [IPR015443]", "Alkyldihydroxyacetonephosphate synthase [IPR025650]", "Alpha E-catenin/Alpha T-catenin [IPR030047]", "Alpha-2-macroglobulin receptor-associated protein [IPR038003]", "Alpha-D-phosphohexomutase superfamily [IPR005841]", "Alpha-L-fucosidase, metazoa-type [IPR016286]", "Alpha-N-acetylglucosaminidase [IPR007781]", "Alpha-N-methyltransferase NTM1 [IPR008576]", "Alpha-adducin [IPR027766]", "Alpha-catenin [IPR001033]", "Alpha-catulin 1 [IPR030045]", "Alpha-internexin [IPR027703]", "Alpha-ketoglutarate-dependent dioxygenase FTO [IPR032868]", "Amidase [IPR000120]", "Amidophosphoribosyltransferase [IPR005854]", "Amino acid/polyamine transporter I [IPR002293]", "Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 [IPR042360]", "Aminoacyl-tRNA synthetase, class Ic [IPR002305]", "Aminopeptidase N-type [IPR034016]", "Aminopeptidase, leukotriene A4 hydrolase-like [IPR034015]", "Aminotransferase ALAT1/2-like [IPR045088]", "Aminotransferase class-III [IPR005814]", "AmpG-like permease/Acetyl-coenzyme A transporter 1 [IPR004752]", "Amyloid-beta precursor protein [IPR028866]", "Amyloidogenic glycoprotein [IPR008155]", "Anamorsin [IPR007785]", "Anaphase-promoting complex subunit 1 [IPR024990]", "Anaphase-promoting complex subunit 16 [IPR029641]", "Anaphase-promoting complex subunit 2 [IPR044554]", "Anaphase-promoting complex subunit 4 [IPR024789]", "Anaphase-promoting complex subunit 4, metazoa [IPR017169]", "Anaphase-promoting complex subunit 5 [IPR037679]", "Ancient conserved domain protein family [IPR045095]", "Angiomotin [IPR009114]", "Anion exchange protein 2 [IPR002978]", "Anion exchange protein [IPR001717]", "Ankycorbin [IPR042420]", "Ankyrin repeat and LEM domain-containing protein 2 [IPR035007]", "Annexin A1 [IPR002388]", "Annexin A11 [IPR008157]", "Annexin A2 [IPR002389]", "Annexin A4 [IPR002391]", "Annexin A6 [IPR002393]", "Annexin [IPR001464]", "Anoctamin [IPR007632]", "Anoctamin-10 [IPR031291]", "Anoctamin-6 [IPR031295]", "Antifreeze, type III [IPR006013]", "Antigen peptide transporter 1 [IPR013306]", "Antigen peptide transporter 2 [IPR005293]", "Apoptosis inhibitory 5 [IPR008383]", "Apoptosis regulator, Mcl-1 [IPR013281]", "Apyrase [IPR009283]", "Arfaptin family [IPR030798]", "Arfaptin-1 [IPR030793]", "Arginase [IPR014033]", "Arginine and glutamate-rich protein 1 [IPR033371]", "Arginine-tRNA ligase [IPR001278]", "Armadillo repeat protein deleted in velo-cardio-facial syndrome [IPR028444]", "Armadillo repeat-containing protein 6 [IPR040104]", "Arsenical pump ATPase, ArsA/GET3 [IPR016300]", "Arsenical pump ATPase, ArsA/GET3, eukaryotic [IPR027542]", "Arylacetamide deacetylase [IPR017157]", "Arylesterase [IPR002640]", "Ashwin [IPR024887]", "Asparagine synthase, glutamine-hydrolyzing [IPR006426]", "Asparagine-tRNA ligase [IPR004522]", "Asparaginyl endopeptidase [IPR043577]", "Aspartate carbamoyltransferase [IPR002082]", "Aspartate-tRNA ligase, type 1 [IPR004524]", "Aspartate-tRNA synthetase, type 2 [IPR004523]", "Aspartate/ornithine carbamoyltransferase [IPR006130]", "Aspartate/other aminotransferase [IPR000796]", "Aspartyl/Asparaginyl-tRNA synthetase, class IIb [IPR002312]", "Aspartyl/asparaginyl beta-hydroxylase family [IPR039038]", "Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, B subunit [IPR004413]", "Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, subunit B /E [IPR017959]", "Associate of Myc 1 [IPR026060]", "Ataxin2-like [IPR045117]", "Atypical dual specificity phosphatase, subfamily A [IPR020405]", "Atypical kinase COQ8A [IPR034640]", "Aurora kinase [IPR030616]", "Autophagy protein Atg8 ubiquitin-like [IPR004241]", "Autophagy-related protein 9 [IPR007241]", "B-cell receptor-associated protein 29/31 [IPR008417]", "BAG family molecular chaperone regulator 2 [IPR037689]", "BBP/SF1 family [IPR031150]", "BCAS3-like [IPR045142]", "BCP1 family [IPR025602]", "BLOC-2 complex, Hps6 subunit [IPR017218]", "BRCA1-A complex subunit BRE [IPR010358]", "BRCA1-associated [IPR031099]", "BRISC and BRCA1-A complex member 1 [IPR026126]", "Bacterial/eukaryotic lysine-tRNA ligase, class II [IPR034762]", "Baculoviral IAP repeat-containing protein 6 [IPR022103]", "Band 4.1 protein, chordates [IPR021187]", "Band 4.1-like protein 2 [IPR030546]", "Band 4.1-like protein 3 [IPR030691]", "Band 4.1-like protein 5 [IPR030694]", "Band-7 stomatin-like [IPR043202]", "Barrier- to-autointegration factor, BAF [IPR004122]", "Basigin [IPR044157]", "Basigin-like [IPR043204]", "Bax inhibitor 1-related [IPR006214]", "Bcl-2 family [IPR026298]", "Bcl-2-associated transcription factor 1 [IPR026668]", "Bcl2-like [IPR002475]", "Beta tubulin [IPR002453]", "Beta-1,4-glucuronyltransferase 1 [IPR043189]", "Beta-N-acetylglucosaminidase [IPR011496]", "Beta-catenin [IPR013284]", "Beta-catenin-like protein 1 [IPR039678]", "Beta-galactosidase 1-like [IPR026283]", "Beta-hexosaminidase [IPR025705]", "Beta-lactamase HcpB-like [IPR040239]", "Bicarbonate transporter, eukaryotic [IPR003020]", "Bicaudal-D protein [IPR018477]", "Bifunctional polynucleotide phosphatase/kinase PNKP [IPR006550]", "Bifunctional purine biosynthesis protein PurH-like [IPR002695]", "Biliverdin reductase A [IPR017094]", "BolA protein [IPR002634]", "BolA-like protein 2 [IPR045115]", "Brain acid soluble protein 1 [IPR008408]", "Breast cancer type 1 susceptibility protein (BRCA1) [IPR011364]", "Bromodomain adjacent to zinc finger domain protein 2A [IPR028940]", "Bystin [IPR007955]", "C-5 cytosine methyltransferase [IPR001525]", "C-terminal binding protein [IPR043322]", "C2 domain-containing protein 5 [IPR038983]", "CAAX prenyl protease 1 [IPR027057]", "CCR4-NOT transcription complex subunit 1 [IPR040398]", "CCR4-NOT transcription complex subunit 4 [IPR039780]", "CCR4-NOT transcription complex subunit 9 [IPR007216]", "CD2 antigen cytoplasmic tail-binding protein 2/Lin1 [IPR039905]", "CD2-associated protein [IPR028445]", "CD36 family [IPR002159]", "CD36/scavenger receptor class B member 1 [IPR005428]", "CDCA7/CDA7L [IPR040221]", "CDGSH iron-sulfur domain-containing protein 1/2 [IPR045131]", "CDK5 regulatory subunit-associated protein 3 [IPR008491]", "CDP-alcohol phosphatidyltransferase [IPR000462]", "CDP-diacylglycerol-inositol 3-phosphatidyltransferase, eukaryote [IPR014387]", "CEBPZ/Mak21-like [IPR040155]", "CHORD domain containing protein [IPR039790]", "CLIP-associating protein 1 [IPR028399]", "CLU domain containing protein [IPR027523]", "COG complex component, COG2 [IPR009316]", "COMPASS component Swd2/WDR82 [IPR037867]", "COP9 signalosome complex subunit 1 [IPR033008]", "COP9 signalosome complex subunit 2 [IPR037750]", "COP9 signalosome complex subunit 3 [IPR037753]", "COP9 signalosome complex subunit 4 [IPR037754]", "COP9 signalosome complex subunit 5 [IPR037740]", "COP9 signalosome subunit 6 [IPR033859]", "COP9 signalosome, subunit CSN8 [IPR033205]", "COPII coat assembly protein, Sec16 [IPR024880]", "COX15/CtaA family [IPR003780]", "CPSF6/7 family [IPR034772]", "CTP synthase [IPR004468]", "CWF11 family [IPR026300]", "CXXC motif containing zinc binding protein, eukaryotic [IPR008584]", "CYFIP-related Rac1 interactor [IPR039789]", "Cadherin [IPR039808]", "Calcium homeostasis endoplasmic reticulum protein [IPR039037]", "Calcium load-activated calcium channel [IPR008559]", "Calcium uptake protein 1/2/3 [IPR039800]", "Calcium-binding mitochondrial carrier protein Aralar2 [IPR029658]", "Calcium-binding protein CAB45 [IPR027240]", "Calcium-transporting ATPase type 2C member 1 [IPR030336]", "Caldesmon [IPR006017]", "Caldesmon/lymphocyte specific protein [IPR006018]", "Calmodulin-regulated spectrin-associated protein [IPR032940]", "Calpain small subunit 1 [IPR029642]", "Calpain-1 [IPR029643]", "Calpain-2 [IPR029539]", "Calpastatin [IPR026998]", "Calponin-2 [IPR029974]", "Calponin/LIMCH1 [IPR001997]", "Calreticulin [IPR009169]", "Calreticulin/calnexin [IPR001580]", "Calumenin [IPR027239]", "Cap-specific mRNA (nucleoside-2-O-)-methyltransferase 1 [IPR030376]", "Caprin [IPR028816]", "Carbamoyl-phosphate synthase, large subunit [IPR006275]", "Carbamoyl-phosphate synthase, small subunit [IPR006274]", "Carbohydrate sulfotransferase 8-10 [IPR018011]", "Cartilage-associated protein [IPR033212]", "Casein Kinase 2, subunit alpha [IPR045216]", "Casein kinase II, regulatory subunit [IPR000704]", "Cat eye syndrome critical region protein 5 [IPR029621]", "Catechol O-methyltransferase, eukaryotic [IPR017128]", "Catenin delta-1 [IPR028439]", "Cation-dependent mannose-6-phosphate receptor [IPR000296]", "Cationic amino acid transport permease [IPR004755]", "Ccdc97-like [IPR018613]", "Cdc37 [IPR004918]", "Cdc42 [IPR037874]", "Cdc73/Parafibromin [IPR007852]", "Cell cycle and apoptosis regulator protein 2 [IPR028811]", "Cell cycle and apoptosis regulator protein [IPR025224]", "Cell division cycle protein 123 [IPR009772]", "Cell division cycle-associated 7-like protein [IPR033578]", "Cell division cycle-associated protein 2 [IPR033064]", "Cell division protein borealin [IPR018867]", "Cell growth-regulating nucleolar protein [IPR039999]", "Cell-cycle alteration and expression-elevated protein in tumour [IPR032337]", "Centrin 2 [IPR037629]", "Centromere protein I [IPR012485]", "Centromere protein P [IPR027801]", "Centrosomal protein of 170kDa [IPR026644]", "Centrosomal protein of 44kDa [IPR033603]", "Centrosomal protein of 55kDa [IPR038926]", "Centrosomal protein of 72kDa [IPR040146]", "Ceramide glucosyltransferase [IPR025993]", "Ceroid-lipofuscinosis neuronal protein 5 [IPR026138]", "Cgr1-like [IPR005579]", "Chaperone DnaJ [IPR012724]", "Chaperone DnaK [IPR012725]", "Chaperone tailless complex polypeptide 1 (TCP-1) [IPR017998]", "Chaperonin Cpn60/GroEL [IPR001844]", "Chaperonin Cpn60/GroEL/TCP-1 family [IPR002423]", "Chitobiosyldiphosphodolichol beta-mannosyltransferase ALG1-like [IPR026051]", "Chloride channel CLIC-like [IPR009231]", "Chloride channel ClC-3 [IPR002245]", "Chloride channel ClC-7 [IPR002249]", "Chloride channel, voltage gated [IPR001807]", "Chloride intracellular channel protein 1 [IPR030259]", "Chondroitin N-acetylgalactosaminyltransferase [IPR008428]", "Chromatid cohesion factor MAU2 [IPR019440]", "Chromatin assembly factor 1 subunit A [IPR022043]", "Chromatin assembly factor 1 subunit Cac2/CHAF1B/FAS2 [IPR045145]", "Chromatin complexes subunit BAP18 [IPR037931]", "Chromatin-remodeling complex component Sfh1/SNF5 [IPR017393]", "Chromobox protein homolog 2 [IPR042796]", "Chromobox protein homologue 3 [IPR038033]", "Chromodomain-helicase-DNA-binding protein 1-like [IPR031053]", "Chromodomain-helicase-DNA-binding protein 8 [IPR034724]", "Chromosome alignment-maintaining phosphoprotein 1 [IPR039330]", "Cilia- and flagella-associated protein 20/CFAP20DC [IPR040441]", "Cip1-interacting zinc finger protein [IPR026811]", "Citrate synthase [IPR002020]", "Citrate synthase, eukaryotic-type [IPR010109]", "Citron Rho-interacting kinase [IPR017405]", "Claspin [IPR024146]", "Class I-like SAM-dependent O-methyltransferase [IPR002935]", "Clathrin adaptor, mu subunit [IPR001392]", "Clathrin coat assembly protein AP180-like [IPR045192]", "Clathrin interactor 1 [IPR030544]", "Clathrin light chain [IPR000996]", "Clathrin, heavy chain [IPR016341]", "Cleavage and polyadenylation specificity factor subunit 2 [IPR027075]", "Cleavage and polyadenylation specificity factor subunit 6 [IPR034769]", "Cleavage and polyadenylation specificity factor subunit 7 [IPR034770]", "Cleavage stimulation factor subunit 1-like [IPR044633]", "Cleavage stimulation factor subunit 2 [IPR033105]", "Cleavage/polyadenylation specificity factor subunit 5 [IPR016706]", "Cleft lip and palate transmembrane 1 [IPR008429]", "Cleft lip and palate transmembrane protein 1-like protein [IPR030434]", "Clp protease proteolytic subunit /Translocation-enhancing protein TepA [IPR023562]", "Clp protease, ATP-binding subunit ClpX [IPR004487]", "ClpA/B family [IPR001270]", "Co-chaperone protein p23-like [IPR045250]", "Coactosin-like protein [IPR030502]", "Coatomer alpha subunit [IPR016391]", "Coatomer beta subunit (COPB1) [IPR016460]", "Coatomer beta' subunit (COPB2) [IPR016453]", "Coatomer delta subunit [IPR027059]", "Coatomer gamma subunit [IPR017106]", "Coatomer subunit zeta [IPR039652]", "Coatomer, epsilon subunit [IPR006822]", "Cobalamin-dependent methionine synthase [IPR011822]", "Cofactor of BRCA1 [IPR010405]", "Cofilin 1 [IPR027234]", "Cohesin subunit Scc3/SA [IPR039662]", "Coiled-coil and C2 domain-containing protein 1 [IPR039725]", "Coiled-coil domain-containing protein 134 [IPR026321]", "Coiled-coil domain-containing protein 138 [IPR038798]", "Coiled-coil domain-containing protein 22 [IPR008530]", "Coiled-coil domain-containing protein 86 [IPR026570]", "Coiled-coil domain-containing protein 90-like [IPR024461]", "Coiled-coil domain-containing protein 93 [IPR039116]", "Coiled-coil domain-containing protein R3HC1/R3HCL [IPR039884]", "Coilin [IPR024822]", "Condensin complex subunit 2/barren [IPR022816]", "Condensin complex subunit 3 [IPR027165]", "Condensin subunit 1 [IPR007673]", "Condensin subunit 1/Condensin-2 complex subunit D3 [IPR026971]", "Condensin-2 complex subunit D3 [IPR012371]", "Condensin-2 complex subunit G2 [IPR024741]", "Conserved oligomeric Golgi complex subunit 5 [IPR019465]", "Conserved oligomeric Golgi complex subunit 6 [IPR010490]", "Conserved oligomeric Golgi complex subunit 7 [IPR019335]", "Conserved oligomeric Golgi complex, subunit 3 [IPR007265]", "Constitutive coactivator of PPAR-gamma [IPR026784]", "Copine [IPR045052]", "Copper chaperone SCO1/SenC [IPR003782]", "Coproporphyrinogen III oxidase, aerobic [IPR001260]", "Core histone macro-H2A [IPR021171]", "Coronin 1B [IPR027340]", "Coronin 1C [IPR027333]", "Coronin 7 [IPR027331]", "Coronin [IPR015505]", "Cortactin [IPR015503]", "Costars family [IPR044302]", "Cullin [IPR045093]", "Cullin-4B [IPR033044]", "Cullin-associated NEDD8-dissociated protein 1/2 [IPR039852]", "Cwf19-like protein [IPR040194]", "Cyclic nucleotide phosphodiesterase [IPR008431]", "Cyclin [IPR039361]", "Cyclin-dependent kinase 6 [IPR028788]", "Cyclophilin-RNA interacting protein [IPR035542]", "Cyclophilin-type peptidyl-prolyl cis-trans isomerase [IPR024936]", "Cyclophilin-type peptidyl-prolyl cis-trans isomerase, cyclophilin A-like [IPR044666]", "Cysteine desulfurase IscS [IPR010240]", "Cysteine desulfurase [IPR016454]", "Cysteine-tRNA ligase [IPR015803]", "Cysteinyl-tRNA synthetase/mycothiol ligase [IPR024909]", "Cystinyl aminopeptidase [IPR034017]", "Cytochrome P450 [IPR001128]", "Cytochrome P450, E-class, group I [IPR002401]", "Cytochrome P450, E-class, group IV [IPR002403]", "Cytochrome b-c1 complex subunit 7 [IPR003197]", "Cytochrome b-c1 complex subunit 8 [IPR004205]", "Cytochrome b-c1 complex subunit 9 [IPR008027]", "Cytochrome c oxidase assembly factor 3, mitochondrial [IPR041752]", "Cytochrome c oxidase subunit 6C [IPR004204]", "Cytochrome c oxidase subunit IV [IPR013288]", "Cytochrome c oxidase subunit IV family [IPR004203]", "Cytochrome c oxidase subunit VII [IPR039297]", "Cytochrome c oxidase subunit VIIa, metazoa [IPR003177]", "Cytochrome c oxidase subunit VIIa-related, mitochondrial [IPR017267]", "Cytochrome c oxidase, subunit Va/VI [IPR003204]", "Cytochrome c oxidase, subunit Vb [IPR002124]", "Cytochrome c/quinol oxidase subunit II [IPR045187]", "Cytochrome c1 [IPR002326]", "Cytoplasmic FMR1-interacting [IPR008081]", "Cytoplasmic dynein 1 intermediate chain 1/2 [IPR025956]", "Cytoplasmic dynein 2 heavy chain 1 [IPR026815]", "Cytoplasmic tRNA 2-thiolation protein 2 [IPR019407]", "Cytoskeleton-associated protein 2 family [IPR026165]", "Cytoskeleton-associated protein 4 [IPR028428]", "Cytosolic Fe-S cluster assembly factor NUBP2/Cfd1, eukaryotes [IPR028600]", "Cytosolic acyl coenzyme A thioester hydrolase [IPR040170]", "Cytosolic nonspecific dipeptidase/DUG1 [IPR017153]", "Cytospin-A [IPR040166]", "D-3-phosphoglycerate dehydrogenase [IPR006236]", "D-glucuronyl C5-epimerase [IPR039721]", "DDB1- and CUL4-associated factor 8-like [IPR045151]", "DDRGK domain containing protein [IPR019153]", "DDX54/DBP10 family [IPR033517]", "DENND6 [IPR024224]", "DENR family, eukaryotes [IPR005873]", "DNA (cytosine-5)-methyltransferase 1-like [IPR017198]", "DNA damage-binding protein 1 [IPR031297]", "DNA double-strand break repair protein Mre11 [IPR003701]", "DNA fragmentation factor 45 [IPR017299]", "DNA helicase, ATP-dependent, RecQ type [IPR004589]", "DNA ligase, ATP-dependent [IPR000977]", "DNA mismatch repair Msh2-type [IPR011184]", "DNA mismatch repair MutS family [IPR045076]", "DNA mismatch repair protein Msh2 [IPR032642]", "DNA mismatch repair protein MutS/MSH [IPR017261]", "DNA polymerase V/Myb-binding protein 1A [IPR007015]", "DNA polymerase alpha, subunit B [IPR016722]", "DNA polymerase delta/II small subunit family [IPR024826]", "DNA polymerase epsilon catalytic subunit [IPR029703]", "DNA polymerase epsilon, subunit B [IPR016266]", "DNA primase large subunit, eukaryotic/archaeal [IPR007238]", "DNA primase, large subunit, eukaryotic [IPR016558]", "DNA primase, small subunit [IPR002755]", "DNA primase, small subunit, eukaryotic/archaeal [IPR014052]", "DNA repair protein Rad50, eukaryotes [IPR004584]", "DNA repair/transcription protein MET18/MMS19 [IPR039920]", "DNA replication ATP-dependent helicase/nuclease Dna2 [IPR026851]", "DNA replication complex GINS protein Psf2 [IPR007257]", "DNA replication licensing factor Mcm2 [IPR008045]", "DNA replication licensing factor Mcm3 [IPR008046]", "DNA replication licensing factor Mcm5 [IPR008048]", "DNA replication licensing factor Mcm6 [IPR008049]", "DNA replication licensing factor Mcm7 [IPR008050]", "DNA topoisomerase I [IPR001631]", "DNA topoisomerase II, eukaryotic-type [IPR001154]", "DNA topoisomerase II-beta [IPR028467]", "DNA topoisomerase, type IIA [IPR001241]", "DNA-directed DNA polymerase, family B [IPR006172]", "DNA-directed DNA-polymerase, family A, mitochondria [IPR002297]", "DNA-directed RNA pol I, largest subunit [IPR015699]", "DNA-directed RNA polymerase I, subunit RPA34.5 [IPR013240]", "DNA-directed RNA polymerase II subunit Rpb4-like [IPR045222]", "DNA-directed RNA polymerase III subunit RPC3 [IPR039748]", "DNA-directed RNA polymerase subunit RPABC5/Rpb10 [IPR000268]", "DNA-directed RNA polymerase subunit Rpo5/Rpb5 [IPR014381]", "DNA-directed RNA polymerase, phage-type [IPR002092]", "DNA-directed RNA polymerase, subunit 2 [IPR015712]", "DNA-directed RNA polymerase, subunit beta-prime [IPR045867]", "DNA-directed RNA polymerases I and III subunit AC40 [IPR033901]", "DNA2/NAM7-like helicase [IPR045055]", "DPM1-like [IPR039528]", "Death-inducer obliterator 1 [IPR033082]", "Dedicator of cytokinesis [IPR026791]", "Defective-in-cullin neddylation protein [IPR014764]", "Delta l-pyrroline-5-carboxylate synthetase [IPR005766]", "Delta(24)-sterol reductase [IPR040165]", "Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase Ech1-like [IPR045002]", "Delta-1-pyrroline-5-carboxylate dehydrogenase [IPR005931]", "Deltex family [IPR039398]", "Deoxycytidylate deaminase [IPR016473]", "Deoxycytidylate deaminase-related [IPR015517]", "Deoxyhypusine hydroxylase [IPR027517]", "Deoxyhypusine synthase [IPR002773]", "Deoxyuridine triphosphate nucleotidohydrolase [IPR008181]", "Dephospho-CoA kinase [IPR001977]", "Derlin [IPR007599]", "Dermcidin [IPR028130]", "Dermcidin/Lacritin [IPR043557]", "Desmoglein [IPR009123]", "Desmoplakin [IPR028462]", "Desmosomal cadherin [IPR009122]", "Destrin [IPR029924]", "Deubiquitinating enzyme MINDY-3/4 [IPR039785]", "Developmentally regulated GTP-binding protein [IPR045001]", "Dihydrofolate reductase [IPR012259]", "Dihydrolipoamide acetyltransferase/Pyruvate dehydrogenase protein X component [IPR045257]", "Dihydrolipoamide dehydrogenase [IPR006258]", "Dihydrolipoamide succinyltransferase [IPR006255]", "Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex [IPR006257]", "Dihydropyrimidinase-related protein 2 [IPR030615]", "Dihydropyrimidinase-related protein 3 [IPR030628]", "Dihydropyrimidinase-related protein 5 [IPR030626]", "Dihydroxyacetone phosphate acyltransferase [IPR028353]", "Dipeptidyl-peptidase 3 [IPR005317]", "Diphosphomevalonate decarboxylase [IPR029765]", "Diphosphomevalonate/phosphomevalonate decarboxylase [IPR005935]", "Diphthamide synthesis DHP2 [IPR010014]", "Diphthamide synthesis DPH1/DPH2 [IPR016435]", "Diphthine synthase [IPR004551]", "Disks large 1-like [IPR016313]", "Divalent ion tolerance protein, CutA [IPR004323]", "DnaJ homolog subfamily A member 1/2-like [IPR044713]", "DnaJ homolog subfamily C member 8 [IPR042858]", "DnaJ homologue subfamily C member 10 [IPR021170]", "DnaJ homologue subfamily C, GRV2/DNAJC13 [IPR044978]", "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48kDa subunit [IPR005013]", "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit Swp1 [IPR008814]", "Dolichyldiphosphatase 1 [IPR039666]", "Drebrin [IPR028438]", "Drebrin-like protein [IPR029923]", "Dual specificity protein phosphatase 12 [IPR016278]", "Dynactin subunit 3 [IPR009991]", "Dynactin subunit 4 [IPR008603]", "Dynamin [IPR022812]", "Dynamin-1-like protein [IPR030556]", "Dynamin-2 [IPR027188]", "Dynamin-like 120kDa protein, mitochondrial [IPR033047]", "Dynamitin [IPR028133]", "Dynein 1 light intermediate chain [IPR008467]", "Dynein family light intermediate chain [IPR022780]", "Dynein heavy chain [IPR026983]", "Dynein light chain, type 1/2 [IPR001372]", "Dynein regulator LIS1 [IPR017252]", "Dyslexia-associated protein KIAA0319-like [IPR029865]", "Dystrophin/utrophin [IPR035436]", "E3 SUMO-protein ligase Nse2 (Mms21) [IPR026846]", "E3 UFM1-protein ligase 1 [IPR018611]", "E3 ubiquitin ligase Bre1 [IPR013956]", "E3 ubiquitin ligase RBR family [IPR031127]", "E3 ubiquitin ligase UBR4-like [IPR045189]", "E3 ubiquitin-protein ligase ARIH2 [IPR031126]", "E3 ubiquitin-protein ligase CHIP/LubX [IPR045200]", "E3 ubiquitin-protein ligase HECTD1/TRIP12-like [IPR045322]", "E3 ubiquitin-protein ligase HECTD3 [IPR042469]", "E3 ubiquitin-protein ligase RBBP6 family [IPR033489]", "E3 ubiquitin-protein ligase RING1/RING2 [IPR043540]", "E3 ubiquitin-protein ligase RING2 [IPR037937]", "E3 ubiquitin-protein ligase RNF123/RSPRY1-like [IPR045129]", "E3 ubiquitin-protein ligase Rad18 [IPR039577]", "E3 ubiquitin-protein ligase UBR1-like [IPR039164]", "E3 ubiquitin-protein ligase ZNF598/Hel2 [IPR044288]", "E3 ubiquitin-protein ligase listerin [IPR039795]", "E3 ubiquitin-protein ligase, SMURF1 type [IPR024928]", "EB1, Metazoa [IPR027739]", "EB2, vertebrate [IPR027735]", "ECSIT [IPR010418]", "EF-hand calcium-binding domain-containing protein 14 [IPR042352]", "EH domain-binding protein 1 [IPR029944]", "EH domain-containing protein 1/3 [IPR029951]", "EH domain-containing protein 4 [IPR029952]", "ELL/occludin family [IPR031176]", "ELMO domain-containing protein 2 [IPR030724]", "ELP3/YhcC [IPR039661]", "ER lumen protein retaining receptor [IPR000133]", "ER membrane protein complex subunit 1 [IPR026895]", "ER membrane protein complex subunit 2-like [IPR039856]", "ER membrane protein complex subunit 7 [IPR039163]", "ERAP2 aminopeptidase [IPR033528]", "ERG2/sigma1 receptor-like [IPR006716]", "ERp19 [IPR037462]", "Electron transfer flavoprotein alpha subunit/FixB [IPR001308]", "Electron transfer flavoprotein, beta subunit [IPR012255]", "Electron transfer flavoprotein-ubiquinone oxidoreductase [IPR040156]", "Elongation factor 4 [IPR006297]", "Elongation factor G1-like [IPR045044]", "Elongator complex protein 1 [IPR006849]", "Elongator complex protein 2 [IPR037289]", "Elongator complex protein 3-like [IPR034687]", "Elongator complex protein 4 [IPR008728]", "Elongin B [IPR039049]", "Emerin [IPR035004]", "Emopamil-binding protein [IPR007905]", "Endonuclease III-like protein 1 [IPR030841]", "Endonuclease domain-containing 1 protein [IPR039015]", "Endophilin-A [IPR028501]", "Endophilin-B1 [IPR028503]", "Endoplasmic reticulum aninopeptidase 1 [IPR033520]", "Endoplasmic reticulum oxidoreductin 1 [IPR007266]", "Endoplasmic reticulum protein SC65 [IPR033213]", "Endoplasmic reticulum resident protein 29 [IPR016855]", "Endoplasmic reticulum vesicle transporter [IPR045888]", "Endothelin-converting enzyme 1 [IPR029734]", "Engulfment and cell motility protein 2 [IPR030713]", "Enhancer of mRNA-decapping protein 4-like [IPR045152]", "Enhancer of rudimentary [IPR000781]", "Enolase [IPR000941]", "Enoyl-CoA hydratase/isomerase [IPR001753]", "Enoyl-CoA hydratase/isomerase, HIBYL-CoA-H type [IPR032259]", "Ependymin [IPR001299]", "Ephrin receptor type-A /type-B [IPR016257]", "Epimerase family protein SDR39U1 [IPR010099]", "Epoxide hydrolase [IPR016292]", "Epoxide hydrolase-like [IPR000639]", "Erbin [IPR032927]", "Erg28 [IPR005352]", "Ergosterol biosynthesis ERG4/ERG24 [IPR001171]", "Erlin1/2 [IPR033294]", "Est1/Ebs1-like [IPR045153]", "Esterase-like [IPR000801]", "Etoposide-induced 2.4 [IPR009890]", "Eukaryotic porin/Tom40 [IPR027246]", "Eukaryotic rRNA processing [IPR008610]", "Eukaryotic translation elongation factor 1 epsilon-1 [IPR042450]", "Eukaryotic translation initiation factor 2D [IPR039757]", "Eukaryotic translation initiation factor 3 subunit A [IPR027512]", "Eukaryotic translation initiation factor 3 subunit B [IPR011400]", "Eukaryotic translation initiation factor 3 subunit D [IPR007783]", "Eukaryotic translation initiation factor 3 subunit E [IPR016650]", "Eukaryotic translation initiation factor 3 subunit F [IPR027531]", "Eukaryotic translation initiation factor 3 subunit G [IPR017334]", "Eukaryotic translation initiation factor 3 subunit H [IPR027524]", "Eukaryotic translation initiation factor 3 subunit I [IPR027525]", "Eukaryotic translation initiation factor 3 subunit J [IPR013906]", "Eukaryotic translation initiation factor 3 subunit K [IPR009374]", "Eukaryotic translation initiation factor 3 subunit M [IPR027528]", "Eukaryotic translation initiation factor 3 subunit M eIF3m/COP9 signalosome complex subunit 7 COPS7 [IPR045237]", "Eukaryotic translation initiation factor 4 gamma 1 [IPR037584]", "Eukaryotic translation initiation factor 4 gamma 3 [IPR037585]", "Eukaryotic translation initiation factor 4B [IPR033107]", "Exocyst complex component EXOC2/Sec5 [IPR029175]", "Exocyst complex component EXOC3/Sec6 [IPR010326]", "Exocyst complex component EXOC5/Sec10 [IPR033960]", "Exocyst complex component EXOC6/Sec15 [IPR007225]", "Exocyst complex component Exo70 [IPR004140]", "Exocyst complex component Exo84 [IPR033961]", "Exocyst complex component Sec10-like [IPR009976]", "Exonuclease 1 [IPR032641]", "Exosome complex RNA-binding protein 1/RRP40/RRP4 [IPR026699]", "Exosome complex component Csl4 [IPR039771]", "Exosome complex component RRP45 [IPR033100]", "Exosome complex component Rrp43 [IPR033196]", "Exosome complex exonuclease Rrp6-like [IPR045092]", "Exportin 4/7-like [IPR044189]", "Exportin-1/5 [IPR045065]", "Exportin-5 [IPR040018]", "Exportin-7 [IPR040021]", "Exportin-T [IPR040017]", "Eyes absent family [IPR028472]", "Eyes absent homologue 4 [IPR028478]", "Ezrin/radixin/moesin [IPR011174]", "Ezrin/radixin/moesin-like [IPR000798]", "F-actin-capping protein subunit alpha [IPR002189]", "F-actin-capping protein subunit beta [IPR001698]", "F-box-like/WD repeat-containing protein Ebi-like [IPR045183]", "FACT complex subunit Spt16 [IPR040258]", "FAD synthetase with the MoaB/Mog domain [IPR012183]", "FAD-dependent glycerol-3-phosphate dehydrogenase [IPR000447]", "FAD-dependent oxidoreductase SdhA/FrdA/AprA [IPR030664]", "FAM175 family [IPR023238]", "FAM175 family, BRISC complex, Abro1 subunit [IPR023240]", "FAM177 family [IPR028260]", "FAM98 [IPR018797]", "FH1/FH2 domain-containing protein 1 [IPR027647]", "FUN14 [IPR007014]", "Fanconi anaemia protein FANCD2 [IPR029448]", "Fanconi anemia group I protein [IPR026171]", "Far11/STRP [IPR040185]", "Fascin [IPR010431]", "Fascin, metazoans [IPR024703]", "Fascin-1 [IPR030146]", "Fatty acid desaturase [IPR012171]", "Fatty acid oxidation complex, alpha subunit, mitochondrial [IPR012803]", "Fatty acid transport protein 4 [IPR030304]", "Fatty acyl-CoA reductase [IPR026055]", "Fcf2/DNTTIP2 [IPR039883]", "Ferredoxin-NADP+ reductase, adrenodoxin-type [IPR021163]", "Ferrochelatase [IPR001015]", "Fibrillarin [IPR000692]", "Filamin family [IPR044801]", "Filamin-B [IPR029874]", "Fimbrin/Plastin [IPR039959]", "Flagellum site-determining protein YlxH/ Fe-S cluster assembling factor NBP35 [IPR033756]", "Flap endonuclease 1 [IPR023426]", "Flotillin family [IPR027705]", "Focadhesin [IPR021392]", "Focadhesin/RST1 [IPR045163]", "Forkhead box protein C1 [IPR033067]", "Formate-tetrahydrofolate ligase, FTHFS [IPR000559]", "Formin, protein diaphanous homologue 1 [IPR027653]", "Formin, protein diaphanous homologue 3 [IPR027654]", "Four and a half LIM domains protein 1 [IPR042997]", "Fragile X mental retardation syndrome-related protein [IPR040148]", "Fructose-bisphosphate aldolase, class-I [IPR000741]", "Fumarate hydratase, class II [IPR005677]", "Fumarate lyase family [IPR000362]", "Fumarylacetoacetase [IPR005959]", "Fyv10 family [IPR045098]", "Fyv7/TAP26 [IPR013730]", "G-protein alpha subunit, group 12/13 [IPR000469]", "G-protein alpha subunit, group I [IPR001408]", "G-protein alpha subunit, group Q [IPR000654]", "G-protein, gamma subunit [IPR001770]", "G-rich sequence factor 1 [IPR033106]", "G10 protein [IPR001748]", "GDP dissociation inhibitor [IPR018203]", "GDP-fucose protein O-fucosyltransferase 1 [IPR039922]", "GDP-fucose protein O-fucosyltransferase [IPR019378]", "GH3 family [IPR004993]", "GINS complex subunit Sld5 [IPR008591]", "GINS complex, subunit Psf3 [IPR010492]", "GPCR-associated sorting protein [IPR043374]", "GPI ethanolamine phosphate transferase 2 [IPR039527]", "GPI transamidase component Gaa1 [IPR007246]", "GPI transamidase component PIG-T [IPR007245]", "GPI transamidase subunit PIG-U [IPR009600]", "GPI-anchor transamidase [IPR028361]", "GRASP55/65 [IPR007583]", "GRIM-19 [IPR009346]", "GTP-binding protein 1 [IPR039263]", "GTP-binding protein Era [IPR005662]", "GTP-binding protein Obg/CgtA [IPR014100]", "GTP-binding protein Rheb [IPR037586]", "Galactokinase [IPR000705]", "Galectin-3 [IPR015534]", "Galectin-like [IPR044156]", "Gamma-adducin [IPR027772]", "Gamma-glutamylcyclotransferase [IPR017939]", "Gamma-glutamyltranspeptidase [IPR000101]", "Gamma-tubulin complex component protein [IPR007259]", "Ganglioside GM2 activator [IPR028996]", "Ganglioside-induced differentiation-associated protein 1 [IPR034336]", "Gem-associated protein 4 [IPR033265]", "Gemini of Cajal bodies-associated protein 8 [IPR034754]", "General transcription factor 3C polypeptide 4 [IPR044230]", "Geranylgeranyl transferase type-2 subunit alpha [IPR032955]", "Glia maturation factor [IPR011171]", "Glomulin/ALF4 [IPR019516]", "Glucosamine 6-phosphate N-acetyltransferase [IPR039143]", "Glucosamine-6-phosphate isomerase [IPR004547]", "Glucosamine-fructose-6-phosphate aminotransferase, isomerising [IPR005855]", "Glucose-6-phosphate dehydrogenase [IPR001282]", "Glucose-methanol-choline oxidoreductase [IPR012132]", "Glucosidase II beta subunit-like [IPR039794]", "Glutamate 5-kinase/delta-1-pyrroline-5-carboxylate synthase [IPR005715]", "Glutamate carboxypeptidase 2-like [IPR039373]", "Glutamate-cysteine ligase catalytic subunit [IPR004308]", "Glutamate-tRNA ligase, bacterial/mitochondrial [IPR004527]", "Glutamate/acetylglutamate kinase [IPR001057]", "Glutamate/phenylalanine/leucine/valine dehydrogenase [IPR006095]", "Glutaminase [IPR015868]", "Glutamine-tRNA synthetase [IPR004514]", "Glutamyl-tRNA synthetase, archaeal/eukaryotic cytosolic [IPR004526]", "Glutamyl-tRNA(Gln) amidotransferase A subunit [IPR004412]", "Glutamyl/glutaminyl-tRNA synthetase [IPR000924]", "Glutathione S-transferase Omega/Tau-like [IPR045073]", "Glutathione S-transferase kappa [IPR044088]", "Glutathione S-transferase, Mu class [IPR003081]", "Glutathione S-transferase, omega-class [IPR005442]", "Glutathione S-transferases, class Zeta [IPR005955]", "Glutathione Transferase family [IPR040079]", "Glutathione peroxidase Gpx7, putative [IPR013376]", "Glutathione peroxidase [IPR000889]", "Glutathione reductase, eukaryote/bacterial [IPR006322]", "Glutathione synthase [IPR005615]", "Glutathione-specific gamma-glutamylcyclotransferase [IPR006840]", "Glyceraldehyde-3-phosphate dehydrogenase, type I [IPR006424]", "Glyceraldehyde/Erythrose phosphate dehydrogenase family [IPR020831]", "Glycerol-3-phosphate O-acyltransferase/Dihydroxyacetone phosphate acyltransferase [IPR022284]", "Glycerol-3-phosphate acyltransferase, PlsB [IPR028354]", "Glycerol-3-phosphate dehydrogenase, NAD-dependent [IPR006168]", "Glycerol-3-phosphate dehydrogenase, NAD-dependent, eukaryotic [IPR017751]", "Glycine cleavage system P protein [IPR020581]", "Glycine dehydrogenase (decarboxylating) [IPR003437]", "Glycogen debranching enzyme [IPR010401]", "Glycogen debranching enzyme, metazoa [IPR006421]", "Glycogen synthase [IPR008631]", "Glycogen synthase kinase-3 beta [IPR033573]", "Glycogen/starch/alpha-glucan phosphorylase [IPR011833]", "Glycoside hydrolase family 30 [IPR001139]", "Glycoside hydrolase family 31 [IPR000322]", "Glycoside hydrolase family 63 [IPR004888]", "Glycoside hydrolase, family 27 [IPR002241]", "Glycoside hydrolase, family 29 [IPR000933]", "Glycoside hydrolase, family 35 [IPR001944]", "Glycosyl transferase, family 25 [IPR002654]", "Glycosyl transferase, family 31 [IPR002659]", "Glycosyl transferase, family 35 [IPR000811]", "Glycosyl transferase, family 8 [IPR002495]", "Glycyl-tRNA synthetase [IPR002315]", "Glycyl-tRNA synthetase/DNA polymerase subunit gamma-2 [IPR027031]", "Glyoxalase I [IPR004361]", "Glyoxalase domain-containing protein 4 [IPR043193]", "Golgi SNAP receptor complex, subunit 1 [IPR023601]", "Golgi apparatus protein 1 [IPR039728]", "Golgi integral membrane protein 4 [IPR042336]", "Golgi to ER traffic protein 4 [IPR007317]", "Golgin subfamily A [IPR024858]", "Golgin subfamily A member 3 [IPR033288]", "Golgin subfamily A member 5 [IPR019177]", "Golgin subfamily B member 1 [IPR026202]", "Graves disease carrier protein [IPR002167]", "GroES chaperonin family [IPR020818]", "Groucho/transducin-like enhancer [IPR009146]", "Growth arrest/ DNA-damage-inducible protein-interacting protein 1 [IPR018472]", "GrpE nucleotide exchange factor [IPR000740]", "Guanine nucleotide binding protein (G-protein), alpha subunit [IPR001019]", "Guanine nucleotide-exchange factor Sec12-like [IPR045260]", "H/ACA ribonucleoprotein complex non-core subunit Naf1 [IPR040309]", "H/ACA ribonucleoprotein complex, subunit Gar1/Naf1 [IPR007504]", "H/ACA ribonucleoprotein complex, subunit Nhp2, eukaryote [IPR002415]", "HAD hydrolase, LHPP/HDHD2 [IPR006355]", "HAD hydrolase, subfamily IA [IPR006439]", "HAD-superfamily hydrolase, subfamily IG, 5'-nucleotidase [IPR008380]", "HAD-superfamily hydrolase, subfamily IIA [IPR006357]", "HAD-superfamily hydrolase, subfamily IIA, CECR5 [IPR006353]", "HAUS augmin-like complex subunit 1 [IPR026243]", "HAUS augmin-like complex subunit 3 [IPR026206]", "HAUS augmin-like complex subunit 4 [IPR029327]", "HAUS augmin-like complex subunit 4, metazoa [IPR026214]", "HAUS augmin-like complex subunit 5 [IPR029131]", "HAUS augmin-like complex subunit 6 [IPR026797]", "HAUS complex subunit 5, metazoa [IPR026215]", "HCCA isomerase/glutathione S-transferase kappa [IPR014440]", "HIRA-interacting protein 3 [IPR037647]", "HMG-CoA lyase [IPR043594]", "HS1-associating protein X-1 [IPR017248]", "Haem oxygenase [IPR002051]", "Haem oxygenase-like [IPR016053]", "Haloacid dehalogenase-like hydrolase [IPR041492]", "Ham1-like protein [IPR002637]", "Heat shock 70kDa protein 13 [IPR042048]", "Heat shock protein 70 family [IPR013126]", "Heat shock protein Hsp90 family [IPR001404]", "Heat shock protein Sti1-like [IPR045248]", "Helicase MOV-10 [IPR026122]", "Helicase XPB/Ssl2 [IPR001161]", "Helicase superfamily 1/2, DinG/Rad3-like [IPR045028]", "Heme A synthase, type 2 [IPR023754]", "Heparan sulphate 2-O-sulfotransferase [IPR007734]", "Heterochromatin protein 1-binding protein 3 [IPR033061]", "Heterogeneous nuclear ribonucleoprotein C [IPR017347]", "Heterogeneous nuclear ribonucleoprotein K [IPR033090]", "Heterogeneous nuclear ribonucleoprotein M [IPR024667]", "Heterogeneous nuclear ribonucleoprotein U [IPR026745]", "Heterogeneous nuclear ribonucleoprotein U-like protein 1 [IPR027025]", "Hexokinase [IPR001312]", "High mobility group protein HMG-I/HMG-Y, chordates [IPR031079]", "High mobility group protein HMGA [IPR000116]", "High mobility group protein HMGB1 [IPR031076]", "High mobility group protein HMGB3 [IPR031077]", "High mobility group protein HMGN [IPR000079]", "Higher eukaryotic phosphomevalonate kinase [IPR005919]", "Histidine acid phosphatase, eukaryotic [IPR016274]", "Histidine phosphatase superfamily, clade-1 [IPR013078]", "Histidine phosphatase superfamily, clade-2 [IPR000560]", "Histidine triad (HIT) protein [IPR001310]", "Histidine-tRNA ligase [IPR015807]", "Histidine-tRNA ligase/ATP phosphoribosyltransferase regulatory subunit [IPR004516]", "Histone H2A [IPR002119]", "Histone H4 [IPR001951]", "Histone acetyltransferase type B, catalytic subunit [IPR017380]", "Histone deacetylase [IPR003084]", "Histone deacetylase complex subunit SAP130 [IPR024137]", "Histone deacetylase complex, SAP18 subunit [IPR017250]", "Histone deacetylase family [IPR000286]", "Histone demethylase JHDM2-like [IPR045109]", "Histone lysine-specific demethylase [IPR017366]", "Histone methyltransferase complex subunit ASH2 [IPR037353]", "Histone-lysine N-methyltransferase 2A [IPR037927]", "Histone-lysine N-methyltransferase SETD1A [IPR037841]", "Histone-lysine N-methyltransferase SETD2, animal [IPR042294]", "Histone-lysine N-methyltransferase SETDB1 [IPR025796]", "Histone-lysine N-methyltransferase Set1-like [IPR044570]", "HnRNP R/Q splicing factor [IPR006535]", "HnRNP-L/PTB [IPR006536]", "Holocytochrome c/c1 synthase [IPR000511]", "Host cell factor 1 [IPR037854]", "Host cell factor [IPR043536]", "Huntingtin [IPR000091]", "Huntingtin family [IPR028426]", "Hydantoinase/dihydropyrimidinase [IPR011778]", "Hydroxymethylglutaryl-CoA reductase, class I/II [IPR002202]", "Hydroxymethylglutaryl-CoA reductase, eukaryotic/archaeal type [IPR004554]", "Hydroxymethylglutaryl-CoA reductase, metazoan [IPR004816]", "Hydroxymethylglutaryl-CoA synthase, eukaryotic [IPR010122]", "Hypoxanthine phosphoribosyl transferase [IPR005904]", "I-BAR domain containing protein IRSp53 [IPR030128]", "I-BAR domain containing protein IRSp53/IRTKS/Pinkbar [IPR027681]", "ICln [IPR003521]", "IQ calmodulin-binding motif-containing protein 1 [IPR028765]", "Immunity-related GTPase family Q protein [IPR040070]", "Importin beta family [IPR040122]", "Importin subunit alpha [IPR024931]", "Inhibitor of nuclear factor kappa-B kinase-interacting protein [IPR024152]", "Initiation factor 2B-related [IPR000649]", "Initiation factor 4G [IPR045208]", "Inner nuclear membrane protein Man1 [IPR034997]", "Inorganic pyrophosphatase [IPR008162]", "Inosine triphosphate pyrophosphatase [IPR027502]", "Inosine-5'-monophosphate dehydrogenase [IPR005990]", "Inositol 3,4-bisphosphate 4-phosphatase [IPR039034]", "Inositol monophosphatase-like [IPR000760]", "Inositol-tetrakisphosphate 1-kinase [IPR008656]", "Insulin receptor substrate [IPR039011]", "Insulin-like growth factor 2 mRNA-binding protein 2 [IPR028743]", "Integral membrane protein 2 [IPR040145]", "Integral membrane protein EMC3/TMCO1-like [IPR002809]", "Integral membrane protein SYS1 [IPR016973]", "Integral membrane protein SYS1-related [IPR019185]", "Integrator complex subunit 1 [IPR038902]", "Integrator complex subunit 14 [IPR039841]", "Integrator complex subunit 2 [IPR029321]", "Integrator complex subunit 2, metazoa [IPR026236]", "Integrator complex subunit 3 [IPR045334]", "Integrator complex subunit 7 [IPR033060]", "Integrator complex subunit 8 [IPR038751]", "Integrator complex subunit 9 [IPR027074]", "Integrin beta subunit [IPR015812]", "Integrin beta-1 subunit [IPR027071]", "Interferon-induced protein with tetratricopeptide repeat 5 [IPR024125]", "Interferon-stimulated 20kDa exonuclease-like 2 [IPR034933]", "Interleukin enhancer-binding factor 3 [IPR033099]", "Intersectin-2 [IPR027029]", "Intracellular chloride channel [IPR002946]", "Intracellular hyaluronic acid binding protein [IPR026203]", "Intraflagellar transport protein 27 homologue, eukaryotes [IPR034112]", "Intraflagellar transport protein 81 [IPR029600]", "Intron Large complex component GCFC2-like [IPR012890]", "Inverted formin-2 [IPR027649]", "Iron regulatory protein 1 [IPR029784]", "Iron-sulfur protein NUBPL-like [IPR044304]", "Isocitrate dehydrogenase NAD-dependent [IPR004434]", "Isocitrate dehydrogenase NADP-dependent [IPR004790]", "Isoleucine-tRNA ligase [IPR002301]", "Isoleucine-tRNA ligase, type 1 [IPR023585]", "Isoleucine-tRNA ligase, type 2 [IPR023586]", "Isopentenyl-diphosphate delta-isomerase, type 1 [IPR011876]", "Isoprenylcysteine carboxyl methyltransferase [IPR007269]", "Isovaleryl-CoA dehydrogenase [IPR034183]", "J-protein Zuotin/DnaJC2 [IPR044634]", "JNK-interacting protein 3/4 [IPR039911]", "Junction plakoglobin [IPR030461]", "Junctional adhesion molecule A [IPR042456]", "KH domain-containing BBP-like [IPR045071]", "KIF-1 binding protein [IPR022083]", "KIN17-like protein [IPR037321]", "KRR1 interacting protein 1 [IPR018034]", "Kae1/TsaD family [IPR017861]", "Keratin, type I [IPR002957]", "Kindlin/fermitin [IPR037843]", "Kinectin [IPR024854]", "Kinesin light chain [IPR002151]", "Kinesin-like protein KIF20A [IPR027326]", "Kinesin-like protein KIF22 (Kid) [IPR026986]", "Kinesin-like protein [IPR027640]", "Kinetochore protein Ndc80 [IPR005550]", "Kinetochore protein Spc25 [IPR045143]", "Ku70 [IPR006165]", "Ku80 [IPR024193]", "Kynurenine--oxoglutarate transaminase 3 [IPR034612]", "L-lactate dehydrogenase [IPR011304]", "L-lactate/malate dehydrogenase [IPR001557]", "LAMTOR1/MEH1 [IPR028209]", "LAR-interacting protein, Liprin [IPR029515]", "LETM1/MDM38-like [IPR044202]", "LIM domain and actin-binding protein 1 [IPR028740]", "LIM domain and actin-binding protein LIMA-like [IPR045268]", "LRP chaperone MESD [IPR019330]", "La domain containing protein [IPR045180]", "Las1 [IPR007174]", "Learning associated protein 18-like [IPR018784]", "Lecithin:cholesterol/phospholipid:diacylglycerol acyltransferase [IPR003386]", "Lethal(2) giant larvae protein [IPR000664]", "Leucine zipper transcription factor-like protein 1 [IPR026157]", "Leucine-rich PPR motif-containing protein [IPR033490]", "Leucine-tRNA ligase [IPR002302]", "Leucyl-tRNA synthetase, class Ia, archaeal/eukaryotic cytosolic [IPR004493]", "Leukocyte surface antigen CD47 [IPR006704]", "Leukotriene A4 hydrolase/leucine aminopeptidase [IPR012777]", "Leukotriene B4 12-hydroxydehydrogenase/15-oxo-prostaglandin 13-reductase [IPR014190]", "Like-Sm (LSM) domain containing protein, LSm4/SmD1/SmD3 [IPR027141]", "Linker histone H1/H5 [IPR005819]", "Lipase maturation factor [IPR009613]", "Lipase, eukaryotic [IPR025483]", "Lipid droplet-associated hydrolase [IPR019363]", "Liprin-alpha-1 [IPR030438]", "Lon protease [IPR027065]", "Lon protease homologue, chloroplastic/mitochondrial [IPR027503]", "Lon protease, bacterial/eukaryotic-type [IPR004815]", "Long-chain fatty acid CoA synthetase, eukaryotic [IPR045311]", "Low temperature viability protein Ltv1 [IPR007307]", "Luc7-related [IPR004882]", "Lunapark family [IPR040115]", "Lupus La protein [IPR002344]", "Lysine-tRNA ligase, class II [IPR002313]", "Lysophosphatidylserine lipase ABHD12 [IPR026605]", "Lysosome membrane protein II [IPR005429]", "Lysosome-associated membrane glycoprotein [IPR002000]", "M-phase phosphoprotein 6 [IPR019324]", "MCU family [IPR039055]", "MDN2-binding protein [IPR039061]", "MICOS complex subunit MIC19/MIC25 [IPR007964]", "MICOS complex subunit MIC26/MIC27 [IPR019166]", "MICOS complex subunit MIC26/MIC27, animal [IPR033182]", "MICOS complex subunit Mic13 [IPR026769]", "MKRN-like [IPR045072]", "MRG [IPR008676]", "MRPS27/PTCD2 [IPR034913]", "MT-A70-like [IPR007757]", "Macrophage migration inhibitory factor [IPR001398]", "Magnesium transporter protein 1 [IPR006844]", "Major centromere autoantigen B [IPR033062]", "Major facilitator superfamily [IPR011701]", "Major facilitator, sugar transporter-like [IPR005828]", "Mak16 protein [IPR006958]", "Malate dehydrogenase, NAD-dependent, cytosolic [IPR011274]", "Malate dehydrogenase, type 1 [IPR010097]", "Malate dehydrogenase, type 2 [IPR010945]", "Malectin [IPR039155]", "Malic oxidoreductase [IPR001891]", "Manganese/iron superoxide dismutase [IPR001189]", "Mannose-6-phosphate isomerase [IPR016305]", "Mannose-6-phosphate isomerase, type I [IPR001250]", "Mannose-6-phosphate receptor [IPR028927]", "Mediator complex, subunit Med14 [IPR013947]", "Mediator complex, subunit Med17 [IPR019313]", "Mediator complex, subunit Med23 [IPR021629]", "Mediator complex, subunit Med24, [IPR021429]", "Mediator complex, subunit Med4 [IPR019258]", "Mediator of RNA polymerase II transcription subunit 22 [IPR009332]", "Medium-chain dehydrogenase/reductase [IPR045010]", "Medium-chain specific acyl-CoA dehydrogenase [IPR034180]", "Melanoma-associated antigen D2 [IPR028810]", "Melanoma-associated antigen [IPR037445]", "Membralin [IPR019144]", "Membrane insertase YidC/ALB3/OXA1/COX18 [IPR001708]", "Membrane bound O-acyl transferase, MBOAT [IPR004299]", "Membrane-associated, eicosanoid/glutathione metabolism (MAPEG) protein [IPR001129]", "Mesoderm induction early response protein/metastasis-associated protein [IPR040138]", "Metal-dependent protein hydrolase [IPR003226]", "Metastasis-associated protein MTA2 [IPR037964]", "Methionine-tRNA ligase, type 1 [IPR023458]", "Methionine-tRNA synthetase, type 2 [IPR023457]", "Methionyl-tRNA synthetase [IPR014758]", "Methyl-CpG binding protein MeCP2 [IPR017353]", "Methyl-CpG binding protein MeCP2/MBD4 [IPR045138]", "Methyl-CpG-binding domain protein 3 [IPR037965]", "Methylcrotonoyl-CoA carboxylase beta chain MCCB/AccD1-like [IPR045190]", "Methylmalonate-semialdehyde dehydrogenase [IPR010061]", "Methylpurine-DNA glycosylase [IPR003180]", "Methylthioadenosine phosphorylase (MTAP) [IPR010044]", "Methylthiotransferase [IPR005839]", "Methyltransferase, trithorax [IPR016569]", "Mevalonate/galactokinase [IPR006206]", "MiaB-like tRNA modifying enzyme, archaeal-type [IPR006466]", "Microtubule associated protein 1 [IPR026074]", "Microtubule associated protein 1A [IPR015656]", "Microtubule-associated protein 1B [IPR027321]", "Microtubule-associated protein 1S [IPR027322]", "Microtubule-associated protein 4 [IPR027323]", "Microtubule-associated protein 7 family [IPR008604]", "Microtubule-associated protein Jupiter [IPR033335]", "Microtubule-associated protein RP/EB [IPR027328]", "Microtubule-associated protein, MAP65/Ase1/PRC1 [IPR007145]", "Midasin [IPR012099]", "Mini-chromosome maintenance complex protein 4 [IPR008047]", "Mini-chromosome maintenance complex-binding protein [IPR019140]", "Mini-chromosome maintenance protein [IPR031327]", "Minichromosome maintenance protein 10 [IPR040184]", "Mitochondria fission 1 protein [IPR016543]", "Mitochondrial 28S ribosomal protein S31 [IPR026299]", "Mitochondrial 28S ribosomal protein S34 [IPR032053]", "Mitochondrial ATP synthase subunit g, animal [IPR016702]", "Mitochondrial ATPase inhibitor [IPR007648]", "Mitochondrial F1-F0 ATP synthase subunit F, predicted [IPR019344]", "Mitochondrial Rho GTPase 1 [IPR029506]", "Mitochondrial Rho GTPase [IPR021181]", "Mitochondrial antiviral-signalling protein, metazoan [IPR026148]", "Mitochondrial calcium uniporter regulator 1 [IPR012439]", "Mitochondrial carrier UCP-like [IPR002030]", "Mitochondrial carrier protein [IPR002067]", "Mitochondrial dynamics protein MID49/MID51 [IPR045909]", "Mitochondrial glycoprotein [IPR003428]", "Mitochondrial import inner membrane translocase subunit Tim44 [IPR017303]", "Mitochondrial import inner membrane translocase subunit Tim50 [IPR027111]", "Mitochondrial import inner membrane translocase subunit Tim8/13 [IPR039238]", "Mitochondrial import receptor subunit TOM5, metazoa [IPR029179]", "Mitochondrial import receptor subunit Tom22 [IPR005683]", "Mitochondrial inner membrane protein Mitofilin [IPR019133]", "Mitochondrial inner membrane translocase complex, subunit Tim17 [IPR005678]", "Mitochondrial inner membrane translocase complex, subunit Tim23 [IPR005681]", "Mitochondrial outer membrane translocase complex, subunit Tom5 [IPR019603]", "Mitochondrial outer membrane transport complex protein, metaxin [IPR017410]", "Mitochondrial phosphate carrier protein Pic2/Mir1-like [IPR044677]", "Mitochondrial processing peptidase subunit beta [IPR037718]", "Mitochondrial pyruvate carrier [IPR005336]", "Mitochondrial ribonuclease P catalytic subunit [IPR033495]", "Mitochondrial ribosomal protein L48 [IPR027487]", "Mitochondrial-processing peptidase subunit alpha [IPR037715]", "Mitofusin family [IPR027094]", "Mitofusin-1 [IPR027088]", "Mitofusin-2 [IPR027089]", "Mitogen-activated protein (MAP) kinase p38-like [IPR008352]", "Mitogen-activated protein (MAP) kinase phosphatase [IPR008343]", "Mitogen-activated protein (MAP) kinase, ERK1/2 [IPR008349]", "Mitogen-activated protein kinase 14 [IPR038784]", "Mitoguardin [IPR019392]", "Mitotic spindle checkpoint protein Bub1/Mad3 [IPR015661]", "Mo25-like [IPR013878]", "Molecular chaperone regulator BAG [IPR039773]", "Molybdate-anion transporter [IPR008509]", "Molybdate-anion transporter, animal type [IPR030163]", "Molybdenum cofactor sulfurase [IPR028886]", "Molybdopterin biosynthesis protein MoeA-like [IPR038987]", "Monocarboxylate transporter 1 [IPR030757]", "Monocarboxylate transporter [IPR004743]", "Monothiol glutaredoxin-related [IPR004480]", "Mortality factor 4-like protein 1 [IPR038011]", "Mortality factor 4-like protein 2 [IPR038012]", "Mpv17/PMP22 [IPR007248]", "Mrp/NBP35 ATP-binding protein [IPR019591]", "Mucosa-associated lymphoid tissue lymphoma translocation protein 1 [IPR033540]", "Multidrug resistance protein 1 [IPR030258]", "Multiple myeloma tumor-associated protein 2-like [IPR039207]", "Myelin expression factor 2 [IPR034632]", "Myeloid-derived growth factor [IPR018887]", "Myo-inositol-1-phosphate synthase [IPR002587]", "Myotubularin family [IPR030564]", "Myotubularin-related protein 14 [IPR039802]", "Myotubularin-related protein 6 [IPR030581]", "Myristoyl-CoA:protein N-myristoyltransferase [IPR000903]", "N-acetylgalactosamine-6-sulfatase [IPR035626]", "N-acetylglucosamine-6-sulfatase [IPR012251]", "N-acetylglucosamine-6-sulfatase, metazoan [IPR015981]", "N-acetyltransferase Ard1-like [IPR045047]", "N-acetyltransferase B complex, non-catalytic subunit [IPR019183]", "N-alpha-acetyltransferase 40 [IPR039949]", "N-cadherin [IPR030051]", "N-terminal acetyltransferase A, auxiliary subunit [IPR021183]", "N6-adenosine-methyltransferase MT-A70-like [IPR025848]", "NAD(P) transhydrogenase, alpha subunit [IPR026255]", "NAD(P)H-quinone oxidoreductase subunit D/H [IPR022885]", "NAD/FAD transporter SLC25A32-like [IPR044712]", "NADH dehydrogenase 1, beta subcomplex, subunit 6 [IPR019174]", "NADH dehydrogenase, subunit C [IPR010218]", "NADH ubiquinone oxidoreductase, F subunit [IPR011537]", "NADH-quinone oxidoreductase subunit E-like [IPR002023]", "NADH-quinone oxidoreductase, chain I [IPR010226]", "NADH-ubiquinone oxidoreductase, 20 Kd subunit [IPR006138]", "NADH-ubiquinone oxidoreductase, subunit 10 [IPR019377]", "NADH-ubiquinone reductase complex 1 MLRQ subunit [IPR010530]", "NADH:cytochrome b5 reductase-like [IPR001834]", "NADH:ubiquinone oxidoreductase, NDUFB5/SGDH subunit [IPR019173]", "NADH:ubiquinone oxidoreductase, subunit 1/F420H2 oxidoreductase subunit H [IPR001694]", "NADH:ubiquinone oxidoreductase, subunit G [IPR010228]", "NADH:ubiquinone oxidoreductase, subunit NDUFB4 [IPR009866]", "NADPH-cytochrome P450 reductase [IPR023208]", "NDRG [IPR004142]", "NDUFAF3/Mth938 domain-containing protein [IPR007523]", "NEDD8 ultimate buster 1 [IPR039749]", "NEDD8-activating enzyme E1 catalytic subunit [IPR030468]", "NEDD8-activating enzyme E1 regulatory subunit APP-BP1 [IPR030667]", "NF-kappa-B inhibitor-like protein 1 [IPR038753]", "NOL6/Upt22 [IPR005554]", "NPC1-like [IPR004765]", "NSF attachment protein [IPR000744]", "Na(+)/H(+) exchange regulatory cofactor NHERF-1 [IPR031199]", "Na(+)/H(+) exchange regulatory cofactor NHERF-1/2 [IPR017300]", "Nck-associated protein 1 [IPR019137]", "Negative elongation factor E [IPR033102]", "Nesprin-2 [IPR030266]", "Nestin [IPR031211]", "Neurochondrin [IPR008709]", "Neurofilament light polypeptide [IPR027692]", "Neurofilament medium polypeptide [IPR027697]", "Neurogenic locus Notch 2 [IPR022336]", "Neuropilin [IPR014648]", "Neuropilin-1 [IPR027146]", "Niban-like [IPR026088]", "Nibrin [IPR016592]", "Nibrin-related [IPR040227]", "Nicalin [IPR016574]", "Nicastrin [IPR008710]", "Nicotinamide phosphoribosyl transferase [IPR016471]", "Nitric oxide synthase-interacting protein [IPR016818]", "Nonaspanin (TM9SF) [IPR004240]", "Nonsense-mediated mRNA decay protein 3 [IPR039722]", "Nonsense-mediated mRNA decay protein Nmd2/UPF2 [IPR039762]", "Notch [IPR008297]", "Nuclear RNA export factor [IPR030217]", "Nuclear cap-binding protein subunit 1 [IPR027159]", "Nuclear cap-binding protein subunit 3 [IPR019416]", "Nuclear factor hnRNPA1 [IPR021662]", "Nuclear fragile X mental retardation-interacting protein 2 [IPR032747]", "Nuclear mitotic apparatus protein 1 [IPR026650]", "Nuclear polyadenylated RNA-binding protein Nab2/ZC3H14 [IPR040366]", "Nuclear pore complex protein NUP98-NUP96 [IPR037637]", "Nuclear pore complex protein Nup133-like [IPR037624]", "Nuclear pore complex protein [IPR026054]", "Nuclear pore glycoprotein p62, metazoa [IPR033072]", "Nuclear pore membrane glycoprotein 210-like [IPR045197]", "Nuclear pore protein 84/107 [IPR007252]", "Nuclear protein localization protein 4 [IPR016563]", "Nuclear transport factor 2/Mtr2 [IPR045875]", "Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 [IPR026633]", "Nucleobindin [IPR040250]", "Nucleobindin-1 [IPR040253]", "Nucleobindin-2 [IPR028813]", "Nucleolar GTP-binding protein 1 [IPR024926]", "Nucleolar GTP-binding protein 2 [IPR024929]", "Nucleolar and spindle-associated protein 1 [IPR026756]", "Nucleolar complex protein 2 [IPR005343]", "Nucleolar complex protein 4 [IPR027193]", "Nucleolar complex-associated protein 3 [IPR016903]", "Nucleolar pre-ribosomal-associated protein 1 [IPR039844]", "Nucleolar protein 10/Enp2 [IPR040382]", "Nucleolar protein 11 [IPR042859]", "Nucleolar protein 14 [IPR007276]", "Nucleolar protein 7 [IPR039626]", "Nucleolar protein 9 [IPR040000]", "Nucleolar protein Nop56/Nop58 [IPR045056]", "Nucleolar, Nop52 [IPR010301]", "Nucleoplasmin family [IPR004301]", "Nucleoporin NSP1/NUP62 [IPR026010]", "Nucleoporin NUP88/NUP82 [IPR037700]", "Nucleoporin Nup120/160 [IPR021717]", "Nucleoporin Nup186/Nup192/Nup205 [IPR021827]", "Nucleoporin Nup188 [IPR044840]", "Nucleoporin Nup37 [IPR037626]", "Nucleoporin Nup54/Nup57/Nup44 [IPR024864]", "Nucleoporin Nup85-like [IPR011502]", "Nucleoporin Nup88 [IPR019321]", "Nucleoporin Seh1 [IPR037597]", "Nucleoporin interacting component Nup93/Nic96 [IPR007231]", "Nucleoporin p58/p45 [IPR024882]", "Nucleoporin peptidase S59-like [IPR037665]", "Nucleoporin protein Ndc1-Nup [IPR019049]", "Nucleoporin, NUP53 [IPR017389]", "Nucleoporin, Nup155-like [IPR004870]", "Nucleoside 2-deoxyribosyltransferase [IPR007710]", "Nucleoside diphosphate kinase [IPR001564]", "Nucleoside-triphosphatase, THEP1 type [IPR004948]", "Nucleosome assembly protein (NAP) [IPR002164]", "Nucleosome-remodeling factor subunit BPTF [IPR038028]", "NudC domain-containing protein 1 [IPR037895]", "NudC domain-containing protein 3 [IPR027761]", "NudC family [IPR037898]", "OBG-type GTPase [IPR045086]", "OCIA domain-containing protein 1/2 [IPR040187]", "ODR-4-like [IPR029454]", "Occludin [IPR002958]", "Oligoribonuclease [IPR022894]", "Oligosaccharyl transferase complex, subunit OST3/OST6 [IPR021149]", "Oligosaccharyl transferase, STT3 subunit [IPR003674]", "Optic atrophy 3-like [IPR010754]", "Origin recognition complex, subunit 2 [IPR007220]", "Origin recognition complex, subunit 3 [IPR020795]", "Origin recognition complex, subunit 5 [IPR020796]", "Ornithine aminotransferase [IPR010164]", "Orotate phosphoribosyltransferase [IPR023031]", "Orotidine 5'-phosphate decarboxylase [IPR014732]", "Oxidized purine nucleoside triphosphate [IPR003563]", "Oxysterol-binding protein [IPR000648]", "P-type ATPase [IPR001757]", "P-type ATPase subfamily IIC, subunit alpha [IPR005775]", "P-type ATPase, subfamily IIA, SERCA-type [IPR005782]", "P-type ATPase, subfamily V [IPR006544]", "P-type ATPase, subfamily IB [IPR027256]", "P-type ATPase, subfamily IIA, PMR1-type [IPR006413]", "P-type ATPase, subfamily IIB [IPR006408]", "PA2G4 family [IPR004545]", "PAT complex subunit CCDC47 [IPR012879]", "PDCD5-like [IPR002836]", "PDK/BCKDK protein kinase [IPR039028]", "PDZ and LIM domain protein 1 [IPR028537]", "PDZ domain-containing protein 8 [IPR039275]", "PH-interacting protein [IPR028738]", "PHD finger protein 10 [IPR038045]", "PHF5-like [IPR005345]", "PITH domain-containing protein 1-like [IPR045099]", "PP2B [IPR043360]", "PSME3-interacting protein [IPR039845]", "Pachytene checkpoint protein 2-like [IPR044539]", "Palmitoyl protein thioesterase [IPR002472]", "Palmitoyl-protein thioesterase 1 [IPR030294]", "Pantothenate kinase, acetyl-CoA regulated, two-domain type [IPR015844]", "Paraneoplastic encephalomyelitis antigen [IPR002343]", "Paraoxonase2 [IPR008364]", "Pat1-like [IPR039900]", "Paxillin [IPR001904]", "Pentatricopeptide repeat domain-containing protein 3 [IPR037387]", "Peptidase A22B, signal peptide peptidase [IPR007369]", "Peptidase C13, legumain [IPR001096]", "Peptidase C1B, bleomycin hydrolase [IPR004134]", "Peptidase C2, calpain family [IPR022684]", "Peptidase C26 [IPR011697]", "Peptidase C26, gamma-glutamyl hydrolase [IPR015527]", "Peptidase C65, otubain [IPR019400]", "Peptidase C69, dipeptidase A [IPR005322]", "Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase [IPR001930]", "Peptidase M1, aminopeptidase B [IPR015571]", "Peptidase M13 [IPR000718]", "Peptidase M14B, caboxypeptidase D [IPR015567]", "Peptidase M17, leucine aminopeptidase [IPR023042]", "Peptidase M17, leucine aminopeptidase/peptidase B [IPR011356]", "Peptidase M20 [IPR002933]", "Peptidase M24, methionine aminopeptidase [IPR001714]", "Peptidase M24A, methionine aminopeptidase, subfamily 1 [IPR002467]", "Peptidase M24A, methionine aminopeptidase, subfamily 2 [IPR002468]", "Peptidase M28 family [IPR045175]", "Peptidase M3A/M3B [IPR045090]", "Peptidase S10, serine carboxypeptidase [IPR001563]", "Peptidase S26B [IPR001733]", "Peptidase S28 [IPR008758]", "Peptidase S8, subtilisin-related [IPR015500]", "Peptidase S9A, prolyl oligopeptidase [IPR002470]", "Peptidase T1A, proteasome beta-subunit [IPR000243]", "Peptidase family M49 [IPR039461]", "Peptidase, FtsH [IPR005936]", "Peptide chain release factor eRF1/aRF1 [IPR004403]", "Peptidyl-prolyl cis-trans isomerase E [IPR016304]", "Peptidyl-prolyl cis-trans isomerase FKBP2/11 [IPR044609]", "Peptidyl-prolyl cis-trans isomerase FKBP3 [IPR043368]", "Peptidyl-prolyl cis-trans isomerase FKBP4 [IPR031212]", "Peptidyl-prolyl cis-trans isomerase FKBP5 [IPR031210]", "Peptidyl-prolyl cis-trans isomerase PIN4 [IPR043323]", "Peptidyl-tRNA hydrolase, PTH2 [IPR002833]", "Pericentriolar material 1 protein [IPR024138]", "Perilipin [IPR004279]", "Periodic tryptophan protein 1 [IPR044285]", "Periodic tryptophan protein 2 [IPR027145]", "Periphilin-1 [IPR028851]", "Peroxin-3 [IPR006966]", "Peroxiredoxin, AhpC-type [IPR024706]", "Peroxiredoxin-5-like [IPR037944]", "Peroxiredoxin-like 2A [IPR032802]", "Peroxiredoxin-like 2A/B/C [IPR032801]", "Peroxisomal acyl-coenzyme A oxidase [IPR034171]", "Peroxisomal biogenesis factor 11 [IPR008733]", "Peroxisomal membrane protein 14 [IPR025655]", "Peroxysomal long chain fatty acyl transporter [IPR005283]", "Pescadillo [IPR010613]", "Pex19 protein [IPR006708]", "Phenylalanine-tRNA ligase, class IIc, beta subunit [IPR045060]", "Phenylalanyl-tRNA synthetase, class IIc, alpha subunit [IPR004529]", "Phenylalanyl-tRNA synthetase, class IIc, beta subunit, archael/eukaryotic type [IPR004531]", "Phosducin-like [IPR045037]", "Phosphatidate cytidylyltransferase [IPR000374]", "Phosphatidate cytidylyltransferase, eukaryota [IPR016720]", "Phosphatidate cytidylyltransferase, mitochondrial [IPR015222]", "Phosphatidyl serine synthase [IPR004277]", "Phosphatidylethanolamine-binding protein [IPR008914]", "Phosphatidylethanolamine-binding protein, eukaryotic [IPR035810]", "Phosphatidylinositol kinase [IPR015433]", "Phosphatidylinositol transfer protein [IPR001666]", "Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma [IPR016279]", "Phosphatidylinositol-4-phosphate 5-kinase [IPR023610]", "Phosphatidylinositol-binding clathrin assembly protein [IPR030412]", "Phosphatidylinositol-glycan biosynthesis class S protein [IPR019540]", "Phosphatidylserine decarboxylase [IPR033177]", "Phosphatidylserine decarboxylase, eukaryotic type 1 [IPR033661]", "Phosphatidylserine decarboxylase-related [IPR003817]", "Phosphoacetylglucosamine mutase [IPR016657]", "Phosphodiesterase MJ0936/Vps29 [IPR000979]", "Phosphoglucomutase [IPR045244]", "Phosphoglucose isomerase (PGI) [IPR001672]", "Phosphoglycerate kinase [IPR001576]", "Phosphoglycerate mutase 1 [IPR005952]", "Phosphoinositide phospholipase C family [IPR001192]", "Phospholipase B-like [IPR007000]", "Phosphoribosylformylglycinamidine cyclo-ligase [IPR004733]", "Phosphoribosylformylglycinamidine synthase PurL [IPR010073]", "Phosphoribosylglycinamide formyltransferase [IPR004607]", "Phosphoribosylglycinamide synthetase [IPR000115]", "Phosphorylase kinase alpha/beta subunit [IPR008734]", "Phosphoserine aminotransferase [IPR022278]", "Phosphotyrosyl phosphatase activator, PTPA [IPR004327]", "Pinin [IPR039853]", "Pirin [IPR012093]", "Plakin [IPR043197]", "Plakophilin/Delta catenin [IPR028435]", "Plasma membrane calcium-transporting ATPase 1 [IPR030320]", "Plasminogen activator inhibitor 1 RNA-binding protein [IPR027205]", "Plastin-2/3 [IPR039956]", "Plectin [IPR030269]", "Plexin family [IPR031148]", "Polo kinase kinase [IPR022165]", "Poly(A) polymerase [IPR014492]", "Poly(ADP-ribose) glycohydrolase [IPR007724]", "Poly-U binding splicing factor, PUF60-like [IPR006532]", "Polyadenylate binding protein, human types 1, 2, 3, 4 [IPR006515]", "Polyadenylate-binding protein 2 [IPR034911]", "Polynucleotide kinase 3 phosphatase [IPR013954]", "Polyprenyl synthetase [IPR000092]", "Polyribonucleotide 5-hydroxyl-kinase Clp1/Grc3 [IPR045116]", "Polyribonucleotide nucleotidyltransferase [IPR012162]", "Porin, eukaryotic type [IPR001925]", "Porphobilinogen deaminase [IPR000860]", "Pre-mRNA 3' end processing protein Pfs2-like [IPR045245]", "Pre-mRNA-processing factor 19 [IPR038959]", "Pre-mRNA-processing factor 6/Prp1/STA1 [IPR027108]", "Pre-mRNA-processing factor Prp40 [IPR039726]", "Pre-mRNA-processing-splicing factor 8 [IPR027652]", "Pre-mRNA-splicing factor Cwf15/Cwc15 [IPR006973]", "Pre-mRNA-splicing factor 38 [IPR005037]", "Pre-mRNA-splicing factor Cwc2/Slt11 [IPR039171]", "Pre-mRNA-splicing factor Isy1 [IPR009360]", "Pre-mRNA-splicing factor SPF27 [IPR008409]", "Pre-mRNA-splicing factor Spp2-like [IPR045166]", "Pre-mRNA-splicing factor Syf1-like [IPR045075]", "Pre-mRNA-splicing regulator WTAP [IPR033757]", "Pre-rRNA-processing protein Esf1 [IPR039754]", "Pre-rRNA-processing protein PNO1-like [IPR039912]", "Prefoldin alpha subunit, archaea-type [IPR011599]", "Prefoldin alpha-like [IPR004127]", "Prefoldin beta-like [IPR002777]", "Prefoldin subunit 2 [IPR027235]", "Prefoldin subunit 3 [IPR016655]", "Prefoldin, subunit 4 [IPR016661]", "Prenylated rab acceptor PRA1 [IPR004895]", "Prenylcysteine oxidase [IPR017046]", "Prenyltransferase subunit beta [IPR045089]", "Presenilin/signal peptide peptidase [IPR006639]", "Primosome PriB/single-strand DNA-binding [IPR000424]", "Probable E3 ubiquitin-protein ligase makorin-2 [IPR026293]", "Probable methyltransferase TARBP1 [IPR025806]", "Probable methyltransferase Trm3/TARBP1 [IPR045330]", "Probable ubiquitin carboxyl-terminal hydrolase FAF-X [IPR031226]", "Profilin [IPR005455]", "Profilin-1 [IPR029892]", "Profilin-2 [IPR029891]", "Profilin1/2/3, vertebrate [IPR005454]", "Prohibitin [IPR000163]", "Proliferating cell nuclear antigen, PCNA [IPR000730]", "Proline racemase family [IPR008794]", "Proline-rich protein PRCC [IPR018800]", "Proline-tRNA ligase, class IIa, archaeal-type [IPR004499]", "Prolyl 3-hydroxylase 1 [IPR039837]", "Prolyl 3-hydroxylase [IPR039575]", "Prolyl 4-hydroxylase [IPR045054]", "Prostaglandin E synthase 2 [IPR034334]", "Prostaglandin reductase 2 [IPR037399]", "Proteasomal ubiquitin receptor Rpn13/ADRM1 [IPR006773]", "Proteasome B-type subunit [IPR023333]", "Proteasome activator PA28 [IPR009077]", "Proteasome activator complex subunit 4 [IPR035309]", "Proteasome alpha-type subunit [IPR023332]", "Proteasome assembly chaperone 1 [IPR016565]", "Proteasome assembly chaperone 2 [IPR019151]", "Proteasome assembly chaperone 2, eukaryotic [IPR016562]", "Proteasome assembly chaperone 3 [IPR018788]", "Proteasome beta 3 subunit [IPR033811]", "Proteasome component Ecm29 [IPR024372]", "Proteasome subunit alpha 1 [IPR035144]", "Proteasome subunit alpha 3 [IPR037555]", "Proteasome subunit alpha 7 [IPR035190]", "Proteasome subunit alpha2 [IPR034644]", "Proteasome subunit alpha4 [IPR034647]", "Proteasome subunit alpha5 [IPR033812]", "Proteasome subunit alpha6 [IPR034642]", "Proteasome subunit beta 1 [IPR035202]", "Proteasome subunit beta 2 [IPR035206]", "Proteasome subunit beta 4 [IPR016295]", "Proteasome subunit beta 5 [IPR037558]", "Proteasome subunit beta 6 [IPR035140]", "Proteasome subunit beta 7 [IPR035216]", "Proteasome, subunit alpha/beta [IPR001353]", "Protein AATF/Bfr2 [IPR039223]", "Protein BRAWNIN [IPR027858]", "Protein CIP2A [IPR042510]", "Protein DEK [IPR044198]", "Protein Fyv10/E3 ubiquitin-protein transferase MAEA [IPR027714]", "Protein Hgh1 [IPR039717]", "Protein ICln/Lot5/Saf5 [IPR039924]", "Protein LCHN/Anr2 [IPR018626]", "Protein LIN-9/Protein ALWAYS EARLY [IPR010561]", "Protein LYRIC [IPR031402]", "Protein Lsm12-like [IPR039683]", "Protein Mon2-like [IPR026829]", "Protein NDRG3 [IPR030692]", "Protein Njmu-R1 [IPR028280]", "Protein PBDC1, metazoa/fungi [IPR008476]", "Protein PRRC1 [IPR026534]", "Protein PRRC2 [IPR033184]", "Protein Peter Pan-like [IPR045112]", "Protein RCC2 [IPR028641]", "Protein Red-like [IPR039896]", "Protein S100-A11 [IPR028482]", "Protein S100-A13 [IPR028487]", "Protein SON [IPR032922]", "Protein Sgt1-like [IPR044563]", "Protein Spindly, chordates [IPR028593]", "Protein TFG [IPR033512]", "Protein XRP2 [IPR039093]", "Protein arginine N-methyltransferase PRMT5 [IPR007857]", "Protein arginine N-methyltransferase [IPR025799]", "Protein arginine methyltransferase NDUFAF7 [IPR003788]", "Protein diaphanous homologue 2 [IPR027644]", "Protein disulfide-isomerase A6-like [IPR044569]", "Protein disulphide isomerase [IPR005792]", "Protein disulphide-isomerase A4 [IPR017068]", "Protein farnesyltransferase subunit beta [IPR026872]", "Protein flightless-1 [IPR029919]", "Protein furry/Tao3/Mor2 [IPR039867]", "Protein import receptor MAS20 [IPR002056]", "Protein import receptor MAS20, metazoan [IPR022422]", "Protein jagunal [IPR009787]", "Protein kinase C and casein kinase substrate in neurons protein 2 [IPR028521]", "Protein kinase C, alpha/beta/gamma types [IPR014375]", "Protein kinase Mps1 family [IPR027084]", "Protein kish [IPR009653]", "Protein of unknown function DUF1075 [IPR009432]", "Protein of unknown function DUF1387 [IPR009816]", "Protein of unknown function DUF2046 [IPR019152]", "Protein of unknown function DUF4615 [IPR029274]", "Protein of unknown function DUF719 [IPR007998]", "Protein of unknown function DUF842, eukaryotic [IPR008560]", "Protein of unknown function DUF92, TMEM19 [IPR002794]", "Protein patched/dispatched [IPR003392]", "Protein phosphatase 2A regulatory subunit PR55 [IPR000009]", "Protein phosphatase 2A, regulatory B subunit, B56 [IPR002554]", "Protein phosphatase 2C family [IPR015655]", "Protein phosphatase methylesterase, eukaryotic [IPR016812]", "Protein regulator of cytokinesis 1 [IPR032921]", "Protein spinster-like [IPR044770]", "Protein strawberry notch [IPR026741]", "Protein suppressor of sable-like [IPR045124]", "Protein transport Sec61-beta/Sbh [IPR030671]", "Protein transport protein Got1 [IPR045176]", "Protein transport protein SEC31-like [IPR040251]", "Protein transport protein Sec23 [IPR037364]", "Protein transport protein SecG/Sec61-beta/Sbh [IPR016482]", "Protein virilizer [IPR026736]", "Protein wntless [IPR009551]", "Protein-L-histidine N-pros-methyltransferase [IPR007884]", "Protein-L-isoaspartate(D-aspartate) O-methyltransferase [IPR000682]", "Protein-S-isoprenylcysteine O-methyltransferase [IPR025770]", "Protein-glutamate O-methyltransferase [IPR039763]", "Protein-tyrosine phosphatase, low molecular weight [IPR017867]", "Protein-tyrosine phosphatase, low molecular weight, mammalian [IPR002115]", "Protein-tyrosine phosphatase, non-receptor type-1/2 [IPR012265]", "Protein-tyrosine phosphatase, non-receptor type-6, -11 [IPR012152]", "Protein-tyrosine phosphatase-like, PTPLA [IPR007482]", "Protein/nucleic acid deglycase DJ-1 [IPR006287]", "Proteinase inhibitor I25A, stefin [IPR001713]", "Protoporphyrinogen oxidase [IPR004572]", "Pseudouridine synthase I, TruA [IPR001406]", "Pseudouridine synthase PUS1/ PUS2-like [IPR041708]", "Pseudouridine synthase, TruD [IPR001656]", "Pterin 4 alpha carbinolamine dehydratase [IPR001533]", "Pumilio homologue 3 [IPR040059]", "Purine 5'-nucleotidase [IPR016695]", "Purine nucleoside phosphorylase I, inosine/guanosine-specific [IPR011270]", "Purine nucleoside phosphorylase [IPR011268]", "Purine-rich element binding protein family [IPR006628]", "Purine-rich element-binding protein alpha [IPR030500]", "Putative RNA methyltransferase [IPR003750]", "Putative RNA-binding protein 47 [IPR034442]", "Pyridine nucleotide-disulphide oxidoreductase, class I [IPR001100]", "Pyridoxal phosphate-dependent decarboxylase [IPR002129]", "Pyrimidine 5'-nucleotidase, eukaryotic [IPR006434]", "Pyrroline-5-carboxylate reductase [IPR000304]", "Pyruvate carboxylase [IPR005930]", "Pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit, subgroup y [IPR017597]", "Pyruvate dehydrogenase E1 component subunit beta [IPR027110]", "Pyruvate kinase [IPR001697]", "Queuine tRNA-ribosyltransferase accessory subunit QTRTD1 [IPR028592]", "Queuosine salvage protein family [IPR019438]", "RAB11-binding protein RELCH [IPR040362]", "RAD3/XPD family [IPR001945]", "RFT1 [IPR007594]", "RINT-1/Tip20 [IPR007528]", "RLI1 [IPR013283]", "RNA (C5-cytosine) methyltransferase [IPR023267]", "RNA (C5-cytosine) methyltransferase, NOP2 [IPR023273]", "RNA 3'-terminal phosphate cyclase [IPR000228]", "RNA 3'-terminal phosphate cyclase type 1 [IPR017770]", "RNA 3'-terminal phosphate cyclase type 2 [IPR016443]", "RNA binding protein HABP4/SERBP1 [IPR039764]", "RNA cytidine acetyltransferase NAT10 [IPR033688]", "RNA demethylase ALKBH5 [IPR032860]", "RNA exonuclease 4 [IPR034920]", "RNA methyltransferase Bin3-like [IPR039772]", "RNA polymerase I associated factor, A49-like [IPR009668]", "RNA polymerase II associated factor Paf1 [IPR007133]", "RNA polymerase II elongation factor ELL [IPR031184]", "RNA polymerase II transcription factor SIII, subunit A [IPR010684]", "RNA polymerase II transcriptional coactivator Sub1/Tcp4-like [IPR045125]", "RNA polymerase II-associated protein RPAP1/Rba50 [IPR039913]", "RNA polymerase subunit Rpb4/RPC9 [IPR005574]", "RNA polymerase subunit Rpb7-like [IPR045113]", "RNA polymerase-associated protein Ctr9 [IPR031101]", "RNA transcription, translation and transport factor protein [IPR019265]", "RNA-binding motif protein 8 [IPR008111]", "RNA-binding protein 10 [IPR033095]", "RNA-binding protein 26 [IPR034861]", "RNA-binding protein 26/27 [IPR045137]", "RNA-binding protein 45 [IPR033101]", "RNA-binding protein 5 [IPR033094]", "RNA-binding protein 6 [IPR028806]", "RNA-binding protein EWS [IPR033109]", "RNA-binding protein FUS [IPR034459]", "RNA-binding protein NOB1 [IPR039907]", "RNA-induced silencing complex, nuclease component Tudor-SN [IPR016685]", "RNA-splicing ligase RtcB homologue, eukaryotic [IPR027513]", "RNA-splicing ligase, RtcB [IPR001233]", "RNase P subunit p30 [IPR002738]", "ROK family [IPR000600]", "RPA-related protein RADX [IPR040893]", "RSBN1/Dpy-21 [IPR026306]", "RZZ complex, subunit Zw10 [IPR009361]", "RZZ complex, subunit Zwilch [IPR018630]", "Rab GDI protein [IPR000806]", "Rab GTPase-activating protein 1 [IPR033185]", "Rab-like protein 6 [IPR040385]", "Rab12 [IPR041830]", "Rab24 [IPR041828]", "Rab3 [IPR037872]", "Rab35 [IPR041815]", "Rab3GAP catalytic subunit [IPR045700]", "Rab3GAP regulatory subunit [IPR026059]", "Rab9 [IPR041824]", "Rad21/Rec8-like protein [IPR039781]", "Ran GTPase [IPR002041]", "Ran binding protein RanBP1-like [IPR045255]", "Rap guanine nucleotide exchange factor 2 [IPR030739]", "Rap1 GTPase-GDP dissociation stimulator 1 [IPR040144]", "Ras GTPase GNL1-like [IPR043358]", "Ras GTPase-activating protein [IPR039360]", "Ras GTPase-activating protein-binding protein 1 [IPR034375]", "Ras GTPase-activating protein-binding protein 2 [IPR034377]", "Ras GTPase-activating protein-binding protein [IPR039539]", "Ras-like guanine nucleotide exchange factor [IPR008937]", "Ras-related protein Rab-23 [IPR034114]", "Ras-related protein Rab14 [IPR030702]", "Ras-related protein Ral [IPR028412]", "Reduced folate carrier [IPR002666]", "Reduced folate transporter SLC19A1 [IPR028339]", "Regulatory associated protein of TOR [IPR004083]", "Remodeling and spacing factor 1-like [IPR028938]", "Remodelling complex subunit Rsc/polybromo [IPR037382]", "Renal cancer differentiation gene 1 protein [IPR031457]", "Renin receptor-like [IPR012493]", "Replication factor A protein 1 [IPR004591]", "Replication factor A protein 2 [IPR014646]", "Replication factor A protein-like [IPR040260]", "Replication factor C subunit 1 [IPR012178]", "Replication termination factor 2 [IPR006735]", "Reticulon-4-interacting protein 1 [IPR037397]", "Retinoblastoma-binding protein 5/Swd1 [IPR037850]", "Retrieval of early ER protein Rer1 [IPR004932]", "Rho GDP/GTP exchange factor Kalirin/TRIO [IPR028570]", "Rho protein GDP-dissociation inhibitor [IPR000406]", "Rho-associated protein kinase 1/2 [IPR020684]", "Rho-related GTP-binding protein RhoG [IPR042734]", "Ribonuclease CAF1 [IPR006941]", "Ribonuclease H2, subunit A [IPR004649]", "Ribonuclease HII/HIII [IPR001352]", "Ribonuclease III [IPR011907]", "Ribonuclease Nob1, eukaryote [IPR017117]", "Ribonuclease P protein subunit Rpp29/RNP1 [IPR002730]", "Ribonuclease P protein subunit Rpp38 [IPR042848]", "Ribonuclease P/MRP subunit Rpp29 [IPR016848]", "Ribonuclease T2, eukaryotic [IPR033697]", "Ribonuclease T2-like [IPR001568]", "Ribonucleases P/MRP protein subunit Pop1 [IPR039182]", "Ribonucleoprotein PTB-binding 1 [IPR034635]", "Ribonucleoside-diphosphate reductase large subunit [IPR039718]", "Ribonucleotide reductase small subunit [IPR033909]", "Ribonucleotide reductase small subunit family [IPR000358]", "Ribophorin I [IPR007676]", "Ribose-phosphate pyrophosphokinase [IPR005946]", "Ribose-phosphate pyrophosphokinase, bacterial-type [IPR037515]", "Ribosomal RNA adenine dimethylase [IPR011530]", "Ribosomal RNA adenine methyltransferase KsgA/Erm [IPR001737]", "Ribosomal RNA assembly KRR1 [IPR024166]", "Ribosomal RNA large subunit methyltransferase E [IPR015507]", "Ribosomal RNA processing protein 8 [IPR007823]", "Ribosomal RNA-processing protein 15 [IPR012459]", "Ribosomal RNA-processing protein Rrp9-like [IPR039241]", "Ribosomal biogenesis NSA2 family [IPR039411]", "Ribosomal biogenesis regulatory protein [IPR007023]", "Ribosomal biogenesis, methyltransferase, EMG1/NEP1 [IPR005304]", "Ribosomal protein L1 [IPR002143]", "Ribosomal protein L1, mitochondrial [IPR005879]", "Ribosomal protein L1/ribosomal biogenesis protein [IPR028364]", "Ribosomal protein L10P [IPR001790]", "Ribosomal protein L10e [IPR001197]", "Ribosomal protein L11, bacterial-type [IPR006519]", "Ribosomal protein L11/L12 [IPR000911]", "Ribosomal protein L12/P1/P2 family [IPR027534]", "Ribosomal protein L13 [IPR005822]", "Ribosomal protein L13, eukaryotic/archaeal [IPR005755]", "Ribosomal protein L13e [IPR001380]", "Ribosomal protein L14 [IPR039660]", "Ribosomal protein L14P [IPR000218]", "Ribosomal protein L15 [IPR030878]", "Ribosomal protein L15, bacterial-type [IPR005749]", "Ribosomal protein L15e [IPR000439]", "Ribosomal protein L17 [IPR000456]", "Ribosomal protein L18e [IPR000039]", "Ribosomal protein L19 [IPR001857]", "Ribosomal protein L2 [IPR002171]", "Ribosomal protein L2, archaeal-type [IPR023672]", "Ribosomal protein L20 [IPR005813]", "Ribosomal protein L21 [IPR001787]", "Ribosomal protein L21-like [IPR028909]", "Ribosomal protein L21e [IPR001147]", "Ribosomal protein L22, bacterial/chloroplast-type [IPR005727]", "Ribosomal protein L22/L17 [IPR001063]", "Ribosomal protein L22/L17, eukaryotic/archaeal [IPR005721]", "Ribosomal protein L22e [IPR002671]", "Ribosomal protein L23 [IPR019985]", "Ribosomal protein L24 [IPR003256]", "Ribosomal protein L24e [IPR023438]", "Ribosomal protein L24e-related [IPR000988]", "Ribosomal protein L25/L23 [IPR013025]", "Ribosomal protein L26/L24, eukaryotic/archaeal [IPR005756]", "Ribosomal protein L27/L41, mitochondrial [IPR019189]", "Ribosomal protein L27e [IPR001141]", "Ribosomal protein L28/L24 [IPR026569]", "Ribosomal protein L28/L40, mitochondrial [IPR019192]", "Ribosomal protein L28e [IPR002672]", "Ribosomal protein L29/L35 [IPR001854]", "Ribosomal protein L29e [IPR002673]", "Ribosomal protein L3 [IPR000597]", "Ribosomal protein L3, archaeal/eukaryotic type [IPR045077]", "Ribosomal protein L3, bacterial/organelle-type [IPR019927]", "Ribosomal protein L30/YlxQ [IPR039109]", "Ribosomal protein L30e [IPR000231]", "Ribosomal protein L31e [IPR000054]", "Ribosomal protein L32e [IPR001515]", "Ribosomal protein L34Ae [IPR008195]", "Ribosomal protein L35A [IPR001780]", "Ribosomal protein L36e [IPR000509]", "Ribosomal protein L37/S30 [IPR010793]", "Ribosomal protein L37ae [IPR002674]", "Ribosomal protein L37e [IPR001569]", "Ribosomal protein L38e [IPR002675]", "Ribosomal protein L4, eukaryotic and archaeal type [IPR045240]", "Ribosomal protein L4/L1e [IPR002136]", "Ribosomal protein L44e [IPR000552]", "Ribosomal protein L47, mitochondrial [IPR010729]", "Ribosomal protein L49/IMG2 [IPR007740]", "Ribosomal protein L5 [IPR002132]", "Ribosomal protein L5 eukaryotic/L18 archaeal [IPR005485]", "Ribosomal protein L50, mitochondria [IPR018305]", "Ribosomal protein L53, mitochondrial [IPR019716]", "Ribosomal protein L6 [IPR000702]", "Ribosomal protein L7, eukaryotic [IPR005998]", "Ribosomal protein L7/L12 [IPR000206]", "Ribosomal protein L7/L30 [IPR039699]", "Ribosomal protein L7A/L8 [IPR001921]", "Ribosomal protein L7Ae/L8/Nhp2 family [IPR018492]", "Ribosomal protein L9 [IPR000244]", "Ribosomal protein P2 [IPR044076]", "Ribosomal protein S10 [IPR001848]", "Ribosomal protein S10, eukaryotic/archaeal [IPR005729]", "Ribosomal protein S11 [IPR001971]", "Ribosomal protein S12/S23 [IPR006032]", "Ribosomal protein S12e [IPR000530]", "Ribosomal protein S13 [IPR001892]", "Ribosomal protein S14 [IPR001209]", "Ribosomal protein S15 [IPR000589]", "Ribosomal protein S15P [IPR023029]", "Ribosomal protein S16 [IPR000307]", "Ribosomal protein S17, archaeal/eukaryotic [IPR028333]", "Ribosomal protein S17/S11 [IPR000266]", "Ribosomal protein S17e [IPR001210]", "Ribosomal protein S18 [IPR001648]", "Ribosomal protein S19/S15 [IPR002222]", "Ribosomal protein S19A/S15e [IPR005713]", "Ribosomal protein S19e [IPR001266]", "Ribosomal protein S2 [IPR001865]", "Ribosomal protein S2, eukaryotic [IPR027498]", "Ribosomal protein S2, eukaryotic/archaeal [IPR005707]", "Ribosomal protein S21e [IPR001931]", "Ribosomal protein S22, mitochondrial [IPR019374]", "Ribosomal protein S23, eukaryotic/archaeal [IPR005680]", "Ribosomal protein S23, mitochondrial [IPR019520]", "Ribosomal protein S23/S29, mitochondrial [IPR019368]", "Ribosomal protein S24/S35, mitochondrial [IPR039848]", "Ribosomal protein S24e [IPR001976]", "Ribosomal protein S25 [IPR004977]", "Ribosomal protein S26e [IPR000892]", "Ribosomal protein S27/S33, mitochondrial [IPR013219]", "Ribosomal protein S28, mitochondrial [IPR019375]", "Ribosomal protein S28e [IPR000289]", "Ribosomal protein S29, mitochondrial [IPR008092]", "Ribosomal protein S3, eukaryotic/archaeal [IPR005703]", "Ribosomal protein S30 [IPR006846]", "Ribosomal protein S30, mitochondrial [IPR039982]", "Ribosomal protein S3Ae [IPR001593]", "Ribosomal protein S4/S9 [IPR022801]", "Ribosomal protein S4/S9, eukaryotic/archaeal [IPR005710]", "Ribosomal protein S4e [IPR000876]", "Ribosomal protein S5 [IPR000851]", "Ribosomal protein S5, eukaryotic/archaeal [IPR005711]", "Ribosomal protein S5/S7 [IPR000235]", "Ribosomal protein S5/S7, eukaryotic/archaeal [IPR005716]", "Ribosomal protein S6 kinase II [IPR016239]", "Ribosomal protein S6, eukaryotic [IPR014401]", "Ribosomal protein S6e [IPR001377]", "Ribosomal protein S7e [IPR000554]", "Ribosomal protein S8 [IPR000630]", "Ribosomal protein S8e [IPR001047]", "Ribosomal protein S8e/ribosomal biogenesis NSA2 [IPR022309]", "Ribosomal protein S9 [IPR000754]", "Ribosome assembly factor Mrt4 [IPR033867]", "Ribosome biogenesis factor, NIP7 [IPR016686]", "Ribosome biogenesis protein BRX1 [IPR026532]", "Ribosome biogenesis protein Bms1/Tsr1 [IPR039761]", "Ribosome biogenesis protein Nop16 [IPR019002]", "Ribosome biogenesis protein Nop53/GLTSCR2 [IPR011687]", "Ribosome biogenesis protein Rpf2 [IPR039770]", "Ribosome maturation protein Sdo1/SBDS [IPR002140]", "Ribosome maturation protein Sdo1/SBDS-like [IPR039100]", "Ribosome recycling factor [IPR002661]", "Ribosome-binding ATPase YchF/Obg-like ATPase 1 [IPR004396]", "Ribosome-binding protein 1 [IPR040248]", "RidA family [IPR006056]", "Rieske iron-sulphur protein [IPR014349]", "Roundabout homologue 1 [IPR032986]", "RuvB-like [IPR027238]", "RuvB-like helicase 1 [IPR037938]", "RuvB-like helicase 2 [IPR037942]", "S-adenosylmethionine synthetase [IPR002133]", "S-formylglutathione hydrolase [IPR014186]", "S-phase kinase-associated protein 1 [IPR016897]", "S-phase kinase-associated protein 1-like [IPR001232]", "SAGA-associated factor 29 [IPR037802]", "SAP30-binding protein [IPR012479]", "SAPAP family [IPR005026]", "SCAMP [IPR007273]", "SERRATE/Ars2 [IPR039727]", "SHC SH2 domain-binding protein 1-like [IPR045140]", "SIT4 phosphatase-associated protein family [IPR007587]", "SKI-interacting protein, SKIP [IPR017862]", "SLC12A transporter family [IPR004842]", "SNF5/SMARCB1/INI1 [IPR006939]", "SNU66/SART1 family [IPR005011]", "SNX17/27/31 [IPR037831]", "SOS response associated peptidase (SRAP) [IPR003738]", "SOUL haem-binding protein [IPR006917]", "SPIN90/Ldb17 [IPR030125]", "STEEP-like [IPR029704]", "SUMO-activating enzyme subunit Uba2 [IPR030661]", "SUN domain-containing protein 1 [IPR018539]", "SUN domain-containing protein 1-5 [IPR045119]", "SUN domain-containing protein 2 [IPR030272]", "SURP and G-patch domain-containing protein 1/2 [IPR040169]", "SWI/SNF complex subunit BRG1 [IPR030100]", "SWI/SNF complex subunit SMARCC1 [IPR030087]", "SWI/SNF complex subunit SMARCC2 [IPR038044]", "SWI/SNF-like complex subunit BAF250a [IPR030094]", "SWI/SNF-like complex subunit BAF250/Osa [IPR021906]", "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 [IPR038041]", "SWR1-complex protein 4/DNA methyltransferase 1-associated protein 1 [IPR027109]", "Saposin [IPR008373]", "Saposin, chordata [IPR021165]", "Sarcolemmal membrane-associated protein [IPR030498]", "Sas10/Utp3/C1D [IPR007146]", "Scaffold attachment factor B1 [IPR034781]", "Scaffold attachment factor B2 [IPR034782]", "Scavenger mRNA decapping enzyme DcpS/DCS2 [IPR008594]", "Scc2/Nipped-B family [IPR033031]", "Schlafen family [IPR029684]", "Sda1 [IPR027312]", "Sdc1/DPY30 [IPR037856]", "Sds3-like [IPR013907]", "Sec1-like protein [IPR001619]", "Sec13/Seh1 family [IPR037363]", "Sec20 [IPR005606]", "SecY/SEC61-alpha family [IPR002208]", "Sentrin-specific protease 3 [IPR037945]", "Sepiapterin reductase [IPR006393]", "Septin 2 [IPR008113]", "Septin 7 [IPR008115]", "Septin 9 [IPR030645]", "Septin [IPR016491]", "Septin and tuftelin interacting protein [IPR024933]", "Serine hydroxymethyltransferase [IPR001085]", "Serine-tRNA ligase, type1 [IPR002317]", "Serine/arginine-rich splicing factor 10 [IPR034476]", "Serine/arginine-rich splicing factor 11 [IPR034447]", "Serine/threonine protein phosphatase 5 [IPR011236]", "Serine/threonine-protein kinase OSR1 [IPR028749]", "Serine/threonine-protein kinase PAK2 [IPR035065]", "Serine/threonine-protein kinase SMG1 [IPR031559]", "Serine/threonine-protein kinase TOR [IPR026683]", "Serine/threonine-protein kinase TOUSLED-like 2 [IPR027086]", "Serine/threonine-protein kinase Vps15-like [IPR045162]", "Serine/threonine-protein phosphatase 2A subunit A, metazoa [IPR031090]", "Serine/threonine-protein phosphatase 4 regulatory subunit 1 [IPR031087]", "Serine/threonine-protein phosphatase PP1-alpha catalytic subunit [IPR037979]", "Serpin H1 [IPR033547]", "Serpin family [IPR000215]", "Shootin-1 [IPR024849]", "Short transmembrane mitochondrial protein 1 [IPR027854]", "Short-chain dehydrogenase/reductase SDR [IPR002347]", "Sideroflexin-4 [IPR028825]", "Sigma intracellular receptor 2 [IPR016964]", "Signal peptidase complex catalytic subunit SEC11A [IPR037712]", "Signal peptidase complex subunit 3 [IPR007653]", "Signal peptidase complex subunit Spc2/SPCS2 [IPR009582]", "Signal recognition particle SRP9 [IPR039914]", "Signal recognition particle receptor, beta subunit [IPR019009]", "Signal recognition particle subunit SRP68 [IPR026258]", "Signal recognition particle, SRP14 subunit [IPR003210]", "Signal recognition particle, SRP54 subunit [IPR022941]", "Signal recognition particle, SRP54 subunit, eukaryotic [IPR006325]", "Signal recognition particle, SRP72 subunit [IPR026270]", "Signal recognition particle, SRP9 subunit [IPR008832]", "Sin3 associated polypeptide p18 [IPR010516]", "Single-stranded DNA-binding protein [IPR011344]", "Sister chromatid cohesion protein Pds5 [IPR039776]", "Ski3/TTC37 [IPR039226]", "Sm-like protein Lsm6/SmF [IPR016487]", "Sm-like protein Lsm7 [IPR017132]", "Sm-like protein Lsm7/SmG [IPR044641]", "Small (40S) ribosomal subunit Asc1/RACK1 [IPR045223]", "Small GTPase Rho [IPR003578]", "Small GTPase [IPR001806]", "Small GTPase superfamily, ARF type [IPR024156]", "Small GTPase superfamily, ARF/SAR type [IPR006689]", "Small GTPase superfamily, SAR1-type [IPR006687]", "Small GTPase, Ras-type [IPR020849]", "Small nuclear ribonucleoprotein E [IPR027078]", "Small nuclear ribonucleoprotein Sm D2 [IPR027248]", "Small nuclear ribonucleoprotein Sm D3 [IPR034099]", "Small-subunit processome, Utp11 [IPR007144]", "Small-subunit processome, Utp14 [IPR006709]", "Smooth muscle protein/calponin [IPR003096]", "Snf7 family [IPR005024]", "Sodium/potassium-transporting ATPase subunit beta [IPR000402]", "Sodium/potassium-transporting ATPase subunit beta, chordates [IPR015565]", "Sodium/solute symporter [IPR001734]", "Sodium:dicarboxylate symporter [IPR001991]", "Solute carrier family 12 member 1/2 [IPR002443]", "Solute carrier family 12 member 2 [IPR002444]", "Solute carrier family 12 member 9 [IPR030345]", "Solute carrier family 25 member 44 [IPR042164]", "Solute carrier family 35 member SLC35F1/F2/F6 [IPR009262]", "Sorbitol dehydrogenase-like [IPR045306]", "Sororin protein [IPR018605]", "Sorting nexin 9 family [IPR014536]", "Sorting nexin-1 [IPR028660]", "Sorting nexin-17 [IPR028666]", "Sorting nexin-19 [IPR034908]", "Sorting nexin-2 [IPR028653]", "Sorting nexin-27 [IPR028667]", "Sorting nexin-5 [IPR028654]", "Sorting nexin-5/6/32 [IPR014637]", "Sorting nexin-6 [IPR028657]", "Sorting nexin-9 [IPR028644]", "Spartin-like [IPR045036]", "Spectrin, beta subunit [IPR016343]", "Sperm-associated antigen 5 [IPR028728]", "Spermatid perinuclear RNA-binding protein [IPR030446]", "Spermatogenesis-defective protein 39 [IPR040057]", "Spermidine/spermine synthase, eukaryotes [IPR030668]", "Spermidine/spermine synthases [IPR001045]", "Spermine synthase, animal [IPR015576]", "Sphingomyelin phosphodiesterase 4 [IPR024129]", "Sphingosine N-acyltransferase Lag1/Lac1-like [IPR016439]", "Spindle and kinetochore-associated protein 1 [IPR009829]", "Spindle and kinetochore-associated protein 3 [IPR033341]", "Splicing factor 3A subunit 1 [IPR045146]", "Splicing factor 3A subunit 3 [IPR031776]", "Splicing factor 3B subunit 1-like [IPR038737]", "Splicing factor 45 [IPR040052]", "Splicing factor ELAV/Hu [IPR006548]", "Splicing factor, RBM39-like [IPR006509]", "Splicing factor, arginine/serine-rich 19 [IPR042841]", "Squalene cyclase [IPR018333]", "Squalene monooxygenase [IPR040125]", "Squalene synthase-like [IPR006449]", "Squalene/phytoene synthase [IPR002060]", "Stathmin family [IPR000956]", "Sterile alpha and TIR motif-containing protein 1 [IPR039184]", "Sterol O-acyltransferase, ACAT/DAG/ARE types [IPR014371]", "Sterol O-acyltransferase, metazoa [IPR030687]", "Sterol transport protein NPC2-like [IPR039670]", "Stomatin [IPR028515]", "Stomatin/HflK/HflC family [IPR001972]", "Structural maintenance of chromosomes flexible hinge domain-containing protein 1 [IPR038892]", "Structural maintenance of chromosomes protein 1A, metazoan [IPR029683]", "Structural maintenance of chromosomes protein 5 [IPR027131]", "Structural maintenance of chromosomes protein [IPR024704]", "Structure-specific recognition protein [IPR000969]", "Succinate dehydrogenase, cytochrome b556 subunit [IPR014314]", "Succinate dehydrogenase, flavoprotein subunit [IPR011281]", "Succinate dehydrogenase/fumarate reductase iron-sulphur protein [IPR004489]", "Succinate dehydrogenase/fumarate reductase type B, transmembrane subunit [IPR000701]", "Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [IPR014006]", "Succinate semialdehyde dehydrogenase [IPR010102]", "Succinate--CoA synthetase, beta subunit [IPR005809]", "Succinyl-CoA ligase, alpha subunit [IPR005810]", "Sulfhydryl oxidase [IPR039798]", "Sulfotransferase [IPR005331]", "Sulfurtransferase TST/MPST-like [IPR045078]", "Suppressor of hairless-like [IPR040159]", "Suppressor of white apricot [IPR040397]", "Surface antigen D15-like [IPR039910]", "Surfeit locus 6 [IPR007019]", "Symplekin/Pta1 [IPR021850]", "Synaptic vesicle protein SV2 [IPR022308]", "Synaptobrevin [IPR001388]", "Synaptogyrin [IPR016579]", "Syndetin [IPR040047]", "Syntaxin [IPR045242]", "Syntaxin-16 [IPR028673]", "Synthesis of cytochrome c oxidase, Sco1/Sco2 [IPR017276]", "T-complex 11 [IPR008862]", "T-complex protein 1, alpha subunit [IPR012715]", "T-complex protein 1, beta subunit [IPR012716]", "T-complex protein 1, delta subunit [IPR012717]", "T-complex protein 1, epsilon subunit [IPR012718]", "T-complex protein 1, eta subunit [IPR012720]", "T-complex protein 1, gamma subunit [IPR012719]", "T-complex protein 1, theta subunit [IPR012721]", "T-complex protein 1, zeta subunit [IPR012722]", "TACC family [IPR039915]", "TAF15/EWS/TLS family [IPR034870]", "TAP46-like protein [IPR007304]", "TATA binding associated factor 15 [IPR034875]", "TATA-binding protein-associated factor Mot1 [IPR044972]", "TB2/DP1/HVA22-related protein [IPR004345]", "TE2IP/Rap1 [IPR039595]", "TFIIH subunit Tfb1/GTF2H1 [IPR027079]", "TFP11/STIP/Ntr1 [IPR045211]", "TH1 protein [IPR006942]", "THO complex subunit 2 [IPR040007]", "THO complex subunit 6 [IPR042626]", "THO complex, subunit 5 [IPR019163]", "THO complex, subunit THOC1 [IPR021861]", "THRAP3/BCLAF1 family [IPR029199]", "THUMP domain-containing protein 1-like [IPR040183]", "TMEM115/Pdh1/Rbl19 [IPR013861]", "TMEM14 family [IPR005349]", "TMEM192 family [IPR029399]", "TMEM33/Pom33 family [IPR005344]", "TNF receptor-associated factor 2 [IPR027133]", "TNF receptor-associated factor TRAF [IPR043211]", "TNF receptor-associated factor TRAF, metazoa [IPR012227]", "TOX high mobility group box family member 4 [IPR037985]", "TPP-binding domain containing protein HACL1-like [IPR045025]", "TPX2 [IPR009675]", "TRAPP I complex, subunit 5 [IPR016696]", "TREX component Tex1/THOC3 [IPR040132]", "Tankyrase 1-binding protein-like [IPR040006]", "TatSF1-like [IPR034393]", "Taxilin family [IPR026183]", "Telomerase RNA component interacting RNase [IPR038838]", "Telomere-associated protein Rif1 [IPR028566]", "Testin [IPR027683]", "Testis-expressed protein 10/pre-rRNA-processing protein Ipi1 [IPR037947]", "Tetrahydrofolate dehydrogenase/cyclohydrolase [IPR000672]", "Tetraspanin, animals [IPR000301]", "Tetraspanin/Peripherin [IPR018499]", "Tetratricopeptide repeat protein 19 [IPR040395]", "Tetratricopeptide repeat protein 26 [IPR030511]", "Tetratricopeptide repeat protein 38 [IPR033891]", "Tetratricopeptide repeat protein TTC27/Emw1 [IPR044244]", "The Golgi pH regulator/GPCR-type G protein [IPR015672]", "ThiF/MoeB/HesA family [IPR045886]", "Thiamine pyrophosphate enzyme [IPR045229]", "Thiolase [IPR002155]", "Thioredoxin domain-containing protein 15 [IPR042418]", "Thioredoxin domain-containing protein 17-like [IPR045108]", "Thioredoxin-related transmembrane protein 2 [IPR039101]", "Thioredoxin/glutathione reductase selenoprotein [IPR006338]", "Threonine-tRNA ligase, class IIa [IPR002320]", "Thymidine kinase [IPR001267]", "Thymidylate kinase [IPR018094]", "Thymidylate synthase [IPR000398]", "Thymidylate synthase/dCMP hydroxymethylase [IPR045097]", "Thyroid hormone receptor-associated protein 3 [IPR026667]", "Tight junction protein ZO [IPR005417]", "Tight junction protein ZO-1 [IPR005418]", "Tight junction protein ZO-2 [IPR005419]", "Tim23-like [IPR045238]", "Tim44-like [IPR039544]", "Tissue alpha-L-fucosidase [IPR028755]", "TmcA/NAT10/Kre33 [IPR032672]", "Tom40 [IPR037930]", "Torsin 1/2 [IPR017378]", "Torsin [IPR010448]", "Torsin-1A [IPR030549]", "Torsin-1A-interacting protein 1/2 [IPR008662]", "Torsin-1B [IPR030550]", "TraB/PrgY/GumN family [IPR002816]", "Trafficking protein particle complex subunit [IPR007233]", "Trans-isoprenyl diphosphate synthases, eukaryotic-type [IPR044844]", "Transaldolase type 1 [IPR004730]", "Transaldolase/Fructose-6-phosphate aldolase [IPR001585]", "Transcription elongation factor SPT5 [IPR039659]", "Transcription elongation factor Spt5, eukaryote [IPR017071]", "Transcription elongation factor Spt6 [IPR017072]", "Transcription elongation factor, IIS-type [IPR035100]", "Transcription elongation factor, TFIIS [IPR006289]", "Transcription elongation factor, mitochondrial [IPR039150]", "Transcription elongation regulator 1-like [IPR045148]", "Transcription facto Tfc3-like [IPR044210]", "Transcription factor BTF3 [IPR039370]", "Transcription factor E [IPR039997]", "Transcription factor II-I [IPR016659]", "Transcription factor IIIC subunit Tfc1/Sfc1 [IPR040454]", "Transcription factor NFX1 family [IPR034078]", "Transcription factor STAT [IPR001217]", "Transcription factor TFIIH subunit p52/Tfb2 [IPR004598]", "Transcription factor Tfc4/TFIIIC-102/Sfc4 [IPR039340]", "Transcription factor, enhancer of yellow 2 [IPR018783]", "Transcription initiation factor IID, subunit 13 [IPR003195]", "Transcription initiation factor IIF, alpha subunit [IPR008851]", "Transcription initiation factor TFIID subunit 6 [IPR037796]", "Transcription initiation factor TFIIE, beta subunit [IPR016656]", "Transcription intermediary factor 1-beta [IPR037373]", "Transcription-associated protein 1 [IPR033317]", "Transcriptional regulatory protein Sin3-like [IPR039774]", "Transcriptional regulatory protein Sin3a [IPR037969]", "Transcriptional repressor p66 [IPR040386]", "Transducin beta-like protein 2 [IPR042410]", "Transferrin receptor protein 1 [IPR029513]", "Transgelin-2 [IPR001061]", "Translation Initiation factor eIF- 4e [IPR001040]", "Translation elongation factor EF1A, eukaryotic/archaeal [IPR004539]", "Translation elongation factor EFG/EF2 [IPR004540]", "Translation elongation factor EFTs/EF1B [IPR001816]", "Translation elongation factor EFTu/EF1A, bacterial/organelle [IPR004541]", "Translation elongation factor IF5A-like [IPR001884]", "Translation initiation factor 2, alpha subunit [IPR011488]", "Translation initiation factor 2A [IPR011387]", "Translation initiation factor 3 complex subunit L [IPR019382]", "Translation initiation factor IF- 2 [IPR015760]", "Translation initiation factor IF2/IF5 [IPR045196]", "Translation initiation factor IF6 [IPR002769]", "Translation machinery-associated protein 16 [IPR021346]", "Translation release factor pelota [IPR004405]", "Translational activator Gcn1 [IPR033173]", "Translationally controlled tumour protein [IPR018105]", "Translin [IPR033956]", "Translin family [IPR002848]", "Translocation protein Sec62 [IPR004728]", "Translocation protein Sec63 [IPR027137]", "Translocator protein [IPR030164]", "Translocon-associated [IPR008855]", "Translocon-associated protein (TRAP), alpha subunit [IPR005595]", "Transmembrane emp24 domain-containing protein 7 [IPR015718]", "Transmembrane emp24 domain-containing protein [IPR015720]", "Transmembrane protein 109 [IPR039492]", "Transmembrane protein 11 [IPR026120]", "Transmembrane protein 126 [IPR009801]", "Transmembrane protein 161A/B [IPR019395]", "Transmembrane protein 201 [IPR040041]", "Transmembrane protein 205 [IPR042623]", "Transmembrane protein 214 [IPR019308]", "Transmembrane protein 230 [IPR044234]", "Transmembrane protein 230/134 [IPR008590]", "Transmembrane protein 43 family [IPR012430]", "Transmembrane protein 65 [IPR019537]", "Transmembrane protein GPR107/GPR108-like [IPR009637]", "Transport protein particle (TRAPP) component [IPR007194]", "Treacle protein [IPR017859]", "Tricarboxylate/iron carrier [IPR004686]", "Trimethyllysine dioxygenase [IPR012776]", "Triosephosphate isomerase [IPR000652]", "Triosephosphate isomerase, bacterial/eukaryotic [IPR022896]", "Tropomodulin [IPR004934]", "Tropomodulin-3 [IPR030133]", "Tropomyosin [IPR000533]", "Tryptophan-tRNA ligase [IPR002306]", "TspO/MBR-related protein [IPR004307]", "Tubulin [IPR000217]", "Tubulin binding cofactor A [IPR004226]", "Tubulin--tyrosine ligase-like protein 12 [IPR027749]", "Tubulin-folding cofactor D [IPR033162]", "Tubulin-specific chaperone E [IPR044994]", "Tubulin-tyrosine ligase/Tubulin polyglutamylase [IPR004344]", "Tumour protein D52 [IPR007327]", "Tweety [IPR006990]", "Twinfilin [IPR028458]", "Twinkle-like protein [IPR027032]", "Type 1 protein exporter [IPR039421]", "Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase [IPR002591]", "Type II pantothenate kinase [IPR004567]", "Type II phosphatidylinositol 4-kinase Lsb6/PI4K2 [IPR039756]", "Tyrosine-tRNA ligase [IPR002307]", "Tyrosine-tRNA ligase, bacterial-type [IPR024088]", "Tyrosine/threonine-protein kinase, Cdc2 inhibitor [IPR016235]", "U1 small nuclear ribonucleoprotein C [IPR017340]", "U2 auxiliary factor small subunit [IPR009145]", "U2 small nuclear ribonucleoprotein A' [IPR044640]", "U2 snRNP auxilliary factor, large subunit, splicing factor [IPR006529]", "U3 small nucleolar RNA-associated protein 10 [IPR040191]", "U3 small nucleolar RNA-associated protein 18 [IPR045161]", "U3 small nucleolar RNA-associated protein 25 [IPR010678]", "U3 small nucleolar RNA-associated protein 6 [IPR013949]", "U3 small nucleolar ribonucleoprotein complex, subunit Mpp10 [IPR012173]", "U3 snoRNP protein/Ribosome production factor 1 [IPR044281]", "U4/U6 small nuclear ribonucleoprotein Prp3 [IPR027104]", "U4/U6 small nuclear ribonucleoprotein Prp31 [IPR027105]", "U6 snRNA-associated Sm-like protein LSm2 [IPR016654]", "UAA transporter [IPR013657]", "UBAP2/protein lingerer [IPR022166]", "UBX domain-containing protein 2/7 [IPR017346]", "UDP-N-acetylglucosamine 2-epimerase,UDP-hydrolysing [IPR020004]", "UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110kDa subunit [IPR037919]", "UDP-glucose 6-dehydrogenase, eukaryotic type [IPR028356]", "UDP-glucose/GDP-mannose dehydrogenase [IPR017476]", "UDP-glucose:Glycoprotein Glucosyltransferase [IPR009448]", "UDP-glucuronosyl/UDP-glucosyltransferase [IPR002213]", "UDP-sugar pyrophosphorylase [IPR039741]", "UDPGP family [IPR002618]", "UHRF1/2-like [IPR045134]", "UMP-CMP kinase [IPR006266]", "UPF0600 protein C5orf51 [IPR037657]", "USP39 [IPR033809]", "UTP--glucose-1-phosphate uridylyltransferase [IPR016267]", "UV excision repair protein Rad23 [IPR004806]", "Ubiquinol-cytochrome-c reductase complex assembly factor 2 [IPR037698]", "Ubiquinone biosynthesis protein COQ9 [IPR012762]", "Ubiquitin binding protein, Hrs/VPS27 [IPR017073]", "Ubiquitin carboxyl-terminal hydrolase 10 [IPR028767]", "Ubiquitin carboxyl-terminal hydrolase 14-like [IPR044635]", "Ubiquitin conjugation factor E4 [IPR045132]", "Ubiquitin domain-containing protein UBFD1 [IPR039120]", "Ubiquitin fusion degradation protein Ufd1-like [IPR004854]", "Ubiquitin thioesterase OTU1/2/3 [IPR039138]", "Ubiquitin thioesterase OTUB1 [IPR030298]", "Ubiquitin thioesterase Otubain [IPR016615]", "Ubiquitin-activating enzyme E1 [IPR018075]", "Ubiquitin-fold modifier 1 [IPR005375]", "Ubiquitin-fold modifier-conjugating enzyme 1 [IPR014806]", "Ubiquitin-like-conjugating enzyme Atg3/Atg10 [IPR007135]", "Ubiquitin-protein ligase E3A [IPR017134]", "Ubiquitin-protein ligase E3B/C [IPR044611]", "Ubiquitin-specific peptidase 24 [IPR033382]", "Ubiquitin/SUMO-activating enzyme E1 [IPR000011]", "Ubiquitinyl hydrolase [IPR016652]", "Ubiquitinyl hydrolase, UCH37 type [IPR017390]", "Uncharacterised conserved protein UCP013899, metal binding [IPR016617]", "Uncharacterised protein family UPF0449 [IPR028227]", "Uncharacterized protein KIAA2013-like [IPR018795]", "Unconventional myosin-XVIIIa [IPR031244]", "Ureohydrolase [IPR006035]", "Uridine kinase-like [IPR000764]", "Uridine-cytidine kinase 2 [IPR029925]", "Uroporphyrinogen decarboxylase HemE [IPR006361]", "V-type ATPase, V0 complex, 116kDa subunit family [IPR002490]", "V-type ATP synthase catalytic alpha chain [IPR022878]", "V-type ATP synthase regulatory subunit B/beta [IPR022879]", "V-type ATPase subunit E [IPR002842]", "V0 complex accessory subunit Ac45 [IPR008388]", "VPRBP/DCAF1 family [IPR033270]", "Vacuolar import/degradation protein Vid24 [IPR018618]", "Vacuolar protein sorting protein 26 related [IPR028934]", "Vacuolar protein sorting-associated protein 13 [IPR026847]", "Vacuolar protein sorting-associated protein 16 [IPR016534]", "Vacuolar protein sorting-associated protein 29 [IPR028661]", "Vacuolar protein sorting-associated protein 33 [IPR027121]", "Vacuolar protein sorting-associated protein 35 [IPR005378]", "Vacuolar protein sorting-associated protein 4 [IPR031255]", "Vacuolar protein sorting-associated protein 51 [IPR014812]", "Vacuolar protein sorting-associated protein 53 [IPR039766]", "Vacuolar protein sorting-associated protein 9-like [IPR045046]", "Vacuolar protein sorting-associated protein Ist1 [IPR005061]", "Vacuolar protein sorting-associated protein Vta1-like [IPR044538]", "Vacuolar protein-sorting protein Bro1-like [IPR045251]", "Valine-tRNA ligase [IPR002303]", "Vam6/VPS39/TRAP1 family [IPR032914]", "Vang-like protein [IPR009539]", "Vesicle transport protein, Got1/SFT2-like [IPR007305]", "Vesicle-associated membrane-protein-associated protein [IPR016763]", "Vesicle-fusing ATPase [IPR039812]", "Vesicle-trafficking protein Sec22 [IPR044565]", "Villin/Gelsolin [IPR007122]", "Vimentin [IPR027699]", "Vinculin [IPR017997]", "Vinculin/alpha-catenin [IPR006077]", "Vitamin K-dependent gamma-carboxylase [IPR007782]", "Voltage-dependent anion-selective channel protein 1 [IPR030270]", "Voltage-dependent anion-selective channel protein 2 [IPR030277]", "Voltage-dependent anion-selective channel protein 3 [IPR030271]", "Vps52 [IPR007258]", "WASH complex subunit 7 [IPR027307]", "WASH complex, subunit strumpellin [IPR019393]", "WD repeat BOP1/Erb1 [IPR028598]", "WD repeat HIR1 [IPR031120]", "WD repeat Prp46/PLRG1-like [IPR045241]", "WD repeat WDR12/Ytm1 [IPR028599]", "WD repeat domain phosphoinositide-interacting protein 2 [IPR032911]", "WD repeat-containing protein 11 [IPR039694]", "WD repeat-containing protein 41 [IPR040102]", "WD repeat-containing protein 73 [IPR042795]", "WD repeat-containing protein 91 [IPR039724]", "WD repeat-containing protein DCAF7-like [IPR045159]", "WD repeat-containing protein WDR18/Ipi3/RID3 [IPR045227]", "WD repeat-containing protein WDR46/Utp7 [IPR040315]", "WD40 repeat-containing protein SMU1 [IPR045184]", "WDR74/Nsa1 [IPR037379]", "WW domain binding protein 11 [IPR019007]", "WW domain-binding protein 2 [IPR033598]", "WW domain-binding protein 2-like [IPR044852]", "Wings apart-like protein [IPR039874]", "Wolframin [IPR026208]", "Wolframin family [IPR026209]", "XAP5 protein [IPR007005]", "XMAP215 family [IPR045110]", "XPG/Rad2 endonuclease [IPR006084]", "Xaa-Arg dipeptidase [IPR017144]", "Xyloside xylosyltransferase 1 [IPR042465]", "YAP-binding/ALF4/Glomulin [IPR013877]", "YEATS [IPR005033]", "YLP motif-containing protein 1 [IPR026314]", "YTH domain containing protein [IPR045168]", "Yif1 family [IPR005578]", "YjeF N-terminal domain-containing protein NAXE-like [IPR032976]", "YjgF/YER057c/UK114 family [IPR006175]", "ZPR1 family [IPR040141]", "Zinc finger CCCH domain-containing protein A/B [IPR039691]", "Zinc finger CCHC domain-containing protein 3 [IPR042509]", "Zinc finger FYVE domain containing protein, SARA/endofin [IPR035438]", "Zinc finger FYVE domain-containing protein, endofin [IPR017165]", "Zinc finger Ran-binding domain-containing protein 2 [IPR017337]", "Zinc finger ZZ-type and EF-hand domain-containing protein 1 [IPR040099]", "Zinc finger protein 622/Rei1/Reh1 [IPR040025]", "Zinc finger protein 638 [IPR033096]", "Zinc/iron permease [IPR003689]", "cAMP-dependent protein kinase catalytic subunit [IPR044109]", "cAMP-dependent protein kinase regulatory subunit [IPR012198]", "dCTP pyrophosphatase 1 [IPR025984]", "dTDP-4-dehydrorhamnose reductase family [IPR005913]", "hnRNP A2/B1 [IPR034489]", "mRNA 3'-end-processing protein Rna14-like [IPR045243]", "mRNA cap guanine-N7 methyltransferase [IPR039753]", "mRNA cap guanine-N7 methyltransferase, eukaryotes [IPR016899]", "mRNA export factor GLE1-like [IPR012476]", "mRNA export factor Gle2/RAE1 [IPR037631]", "mRNA-decapping enzyme subunit 1 [IPR010334]", "p53 tumour suppressor family [IPR002117]", "rRNA biogenesis protein RRP36 [IPR009292]", "rRNA biogenesis protein Rrp5 [IPR045209]", "siRNA-mediated silencing protein NRDE-2 [IPR013633]", "tRNA (C5-cytosine) methyltransferase, NCL1 [IPR023270]", "tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 [IPR017423]", "tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit [IPR028884]", "tRNA (guanine-N1-)-methyltransferase, eukaryotic [IPR007356]", "tRNA (uracil(54)-C(5))-methyltransferase, eukaryotic type [IPR045850]", "tRNA N6-adenosine threonylcarbamoyltransferase Kae1, archaea and eukaryote [IPR034680]", "tRNA guanosine-2'-O-methyltransferase, TRM11 [IPR016691]", "tRNA methyltransferase 10 homologue C [IPR025812]", "tRNA methyltransferase, Trm1 [IPR002905]", "tRNA modification GTPase MnmE [IPR004520]", "tRNA pseudouridine synthase B family [IPR004802]", "tRNA pseudouridine synthase II, TruB [IPR014780]", "tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG [IPR004416]", "tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG-related [IPR002218]", "tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase MiaB [IPR006463]", "tRNA-specific 2-thiouridylase [IPR004506]"], "available_proteins": ["AAAS", "AAR2", "AARS", "AARS2", "AATF", "ABCB1", "ABCB10", "ABCB6", "ABCB7", "ABCB8", "ABCC4", "ABCD3", "ABCE1", "ABHD12", "ABHD6", "ABRACL", "ABRAXAS2", "ACAA1", "ACAA2", "ACADM", "ACAT1", "ACAT2", "ACBD5", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT8", "ACOX1", "ACOX3", "ACP1", "ACP2", "ACP6", "ACSL1", "ACSL6", "ACTL6A", "ACTR1A", "ACTR1B", "ACTR2", "ACTR3", "ACTR8", "ADA", "ADD1", "ADD3", "ADH5", "ADI1", "ADK", "ADNP", "ADPGK", "ADRM1", "ADSL", "ADSS", "AFG3L2", "AGL", "AGPS", "AHCY", "AHCYL1", "AHSA1", "AIMP2", "AIP", "AK1", "AK2", "AK3", "AK4", "AK6", "AKAP8", "AKAP8L", "AKAP9", "AKR1A1", "AKR1B1", "ALDH16A1", "ALDH18A1", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDOA", "ALDOC", "ALG1", "ALG11", "ALKBH5", "AMOT", "ANAPC1", "ANAPC16", "ANAPC2", "ANAPC4", "ANAPC5", "ANKLE2", "ANO10", "ANO6", "ANP32A", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA4", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP1M1", "AP1S1", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "APEX1", "API5", "APOO", "APOOL", "APP", "APRT", "AQR", "ARCN1", "ARF4", "ARF6", "ARFIP1", "ARFIP2", "ARG2", "ARGLU1", "ARHGDIA", "ARID1A", "ARID3B", "ARIH2", "ARL1", "ARL2", "ARL3", "ARL6IP1", "ARL6IP5", "ARL8A", "ARMC1", "ARMC6", "ARMT1", "ARPC1A", "ARPC2", "ARPC3", "ARPC4", "ARVCF", "ASAH1", "ASH2L", "ASNA1", "ASNS", "ASPH", "ATAD2", "ATAD3A", "ATAD3B", "ATG3", "ATG9A", "ATIC", "ATP13A1", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP2B4", "ATP2C1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6AP1", "ATP6AP2", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1D", "ATP6V1E1", "ATP6V1H", "ATP7A", "ATP7B", "ATPAF1", "ATPIF1", "ATRIP", "ATXN2L", "AURKA", "B3GALT6", "B4GAT1", "BABAM1", "BABAM2", "BAG2", "BAG3", "BAG4", "BAG5", "BAIAP2", "BANF1", "BAP18", "BASP1", "BAZ2A", "BCAP31", "BCAS2", "BCAS3", "BCCIP", "BCKDK", "BCLAF1", "BCR", "BICD2", "BIRC6", "BLM", "BLMH", "BLVRA", "BMS1", "BNIP1", "BOLA2*", "BOP1", "BPNT1", "BPTF", "BRCA1", "BRIX1", "BRMS1L", "BSG", "BTAF1", "BTF3", "BUB1B", "BUD23", "BUD31", "BYSL", "C12orf73", "C17orf75", "C19orf25", "C19orf70", "C1QBP", "C1orf123", "C1orf35", "C2CD5", "C2orf49", "C4orf46", "C5orf51", "C8orf33", "C9orf64", "CAB39", "CAD", "CALD1", "CALR", "CALU", "CAMSAP3", "CAND1", "CAND2", "CANT1", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPNS1", "CAPRIN1", "CAPZA1", "CAPZB", "CARS", "CAST", "CBR1", "CBX2", "CBX3", "CC2D1A", "CCAR1", "CCAR2", "CCDC134", "CCDC138", "CCDC22", "CCDC47", "CCDC59", "CCDC6", "CCDC86", "CCDC93", "CCDC97", "CCNB1", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2AP", "CD2BP2", "CD3EAP", "CD47", "CDC123", "CDC37", "CDC42", "CDC73", "CDCA2", "CDCA5", "CDCA7L", "CDCA8", "CDH2", "CDIPT", "CDK5RAP1", "CDK5RAP3", "CDK6", "CDKAL1", "CDS2", "CEBPZ", "CELF2", "CENPB", "CENPI", "CENPP", "CEP170", "CEP44", "CEP55", "CEP72", "CERS2", "CERS5", "CETN2", "CFAP20", "CFL1", "CFL2", "CHAC2", "CHAF1A", "CHAF1B", "CHAMP1", "CHCHD3", "CHD1L", "CHD8", "CHDH", "CHERP", "CHMP2B", "CHMP3", "CHMP4B", "CHMP5", "CHMP7", "CHORDC1", "CHST14", "CIAPIN1", "CIP2A", "CISD2", "CIT", "CIZ1", "CKAP2", "CKAP4", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLCC1", "CLCN3", "CLCN7", "CLGN", "CLIC1", "CLINT1", "CLN5", "CLNS1A", "CLPB", "CLPP", "CLPTM1", "CLPTM1L", "CLPX", "CLSPN", "CLTA", "CLTB", "CLTC", "CLUH", "CMAS", "CMPK1", "CMTR1", "CNDP2", "CNN2", "CNN3", "CNNM3", "CNNM4", "CNOT1", "CNOT4", "CNOT9", "CNP", "COA3", "COA7", "COG2", "COG3", "COG5", "COG6", "COG7", "COIL", "COLGALT1", "COMT", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS8", "COPZ1", "COQ8A", "COQ9", "CORO1B", "CORO1C", "CORO7", "COTL1", "COX15", "COX18", "COX2", "COX4I1", "COX5A", "COX5B", "COX6C", "COX7A2", "COX7A2L", "CPD", "CPNE1", "CPNE2", "CPNE3", "CPNE8", "CPOX", "CPSF2", "CPSF6", "CPSF7", "CPT1A", "CPT2", "CPVL", "CRNKL1", "CRTAP", "CS", "CSGALNACT2", "CSNK2A1", "CSNK2A2", "CSNK2B", "CSTB", "CSTF1", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTNNA1", "CTNNAL1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTPS2", "CTR9", "CTSA", "CTTN", "CTU2", "CUL1", "CUL2", "CUL3", "CUL4A", "CUL4B", "CUL5", "CUTA", "CWC15", "CWF19L1", "CXorf56", "CXorf57", "CYB5R1", "CYB5R3", "CYC1", "CYFIP1", "CYFIP2", "CYP20A1", "CYP51A1", "DAP3", "DARS", "DARS2", "DBN1", "DBNL", "DCAF1", "DCAF7", "DCAF8", "DCAKD", "DCD", "DCP1B", "DCPS", "DCTD", "DCTN2", "DCTN3", "DCTN4", "DCTPP1", "DCUN1D1", "DCUN1D5", "DCXR", "DDB1", "DDOST", "DDRGK1", "DDT", "DDX54", "DEK", "DENND6A", "DENR", "DERL1", "DERL2", "DFFA", "DHCR24", "DHCR7", "DHFR", "DHPS", "DHRS1", "DHRS13", "DHRS7", "DHRS7B", "DHTKD1", "DHX29", "DIAPH1", "DIAPH2", "DIAPH3", "DIDO1", "DIEXF", "DIMT1", "DKC1", "DLAT", "DLD", "DLG1", "DLGAP5", "DLST", "DMAP1", "DNA2", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJC10", "DNAJC13", "DNAJC2", "DNAJC8", "DNM1L", "DNM2", "DNMT1", "DNPH1", "DNTTIP2", "DOCK7", "DOHH", "DOLPP1", "DPH2", "DPH5", "DPM1", "DPP3", "DPY30", "DPYSL2", "DPYSL3", "DPYSL5", "DRG1", "DRG2", "DSC3", "DSCR3", "DSG2", "DSP", "DST", "DSTN", "DTX3L", "DTYMK", "DUSP12", "DUSP3", "DUSP9", "DUT", "DYNC1I2", "DYNC1LI1", "DYNC2H1", "DYNLL1", "DYNLL2", "EARS2", "EBNA1BP2", "EBP", "ECE1", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "ECSIT", "EDC4", "EEF1A2", "EEF1E1", "EEF1G", "EFCAB14", "EHBP1", "EHD1", "EHD4", "EI24", "EIF2A", "EIF2B1", "EIF2B2", "EIF2B4", "EIF2D", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4B", "EIF4E", "EIF4E2", "EIF4G1", "EIF4G2", "EIF4G3", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAVL1", "ELL", "ELMO2", "ELMOD2", "ELOA", "ELOB", "ELP1", "ELP2", "ELP3", "ELP4", "EMC1", "EMC2", "EMC7", "EMD", "EMG1", "ENDOD1", "ENO1", "ENO2", "ENY2", "EPB41", "EPB41L2", "EPB41L3", "EPB41L5", "EPDR1", "EPHA7", "EPHX1", "EPHX2", "EPPK1", "EPRS", "ERAL1", "ERAP1", "ERAP2", "ERBIN", "ERC1", "ERCC2", "ERCC3", "ERG28", "ERGIC1", "ERGIC3", "ERH", "ERLIN1", "ERLIN2", "ERMP1", "ERO1A", "ERO1B", "ERP29", "ESD", "ESF1", "ETF1", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXO1", "EXOC2", "EXOC3", "EXOC5", "EXOC6", "EXOC7", "EXOC8", "EXOSC1", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC8", "EXOSC9", "EYA4", "EZR", "F11R", "FADS2", "FAH", "FAM114A2", "FAM120A", "FAM129B", "FAM136A", "FAM162A", "FAM177A1", "FAM192A", "FAM213A", "FAM49B", "FAM50A", "FAM98A", "FAM98B", "FANCD2", "FANCI", "FAR1", "FARP1", "FARP2", "FARSA", "FARSB", "FAU", "FBL", "FDFT1", "FDPS", "FDXR", "FECH", "FEN1", "FERMT2", "FH", "FHL1", "FHOD1", "FIS1", "FKBP2", "FKBP3", "FKBP4", "FKBP5", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FMR1", "FNTB", "FOCAD", "FOXC1", "FRYL", "FSCN1", "FTO", "FTSJ3", "FUCA1", "FUCA2", "FUNDC2", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GADD45GIP1", "GALK1", "GALM", "GALNS", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GATAD2B", "GATB", "GBA", "GCAT", "GCFC2", "GCLC", "GCN1", "GDAP1", "GDI1", "GDI2", "GEMIN4", "GEMIN8", "GET4", "GFM1", "GFPT1", "GGCT", "GGCX", "GGH", "GGT7", "GHDC", "GHITM", "GID4", "GINS2", "GINS3", "GINS4", "GLA", "GLB1", "GLCE", "GLDC", "GLE1", "GLG1", "GLMN", "GLO1", "GLOD4", "GLRX3", "GLRX5", "GLS", "GLUD1", "GM2A", "GMFB", "GNA13", "GNAI1", "GNAI2", "GNAI3", "GNAQ", "GNE", "GNG12", "GNG5", "GNL1", "GNL2", "GNPAT", "GNPDA1", "GNPNAT1", "GNS", "GOLGA2", "GOLGA3", "GOLGA5", "GOLGB1", "GOLIM4", "GOLT1B", "GORASP2", "GOSR1", "GOT1", "GOT2", "GPAA1", "GPAM", "GPD1L", "GPD2", "GPHN", "GPI", "GPKOW", "GPR107", "GPR108", "GPR89B", "GPRASP2", "GPS1", "GPT2", "GPX8", "GRPEL1", "GRSF1", "GSK3B", "GSR", "GSS", "GSTK1", "GSTM3", "GSTO1", "GSTZ1", "GTF2E1", "GTF2E2", "GTF2F1", "GTF2H1", "GTF2H4", "GTF2I", "GTF3C1", "GTF3C3", "GTF3C4", "GTF3C5", "GTPBP1", "GTPBP10", "GTPBP3", "GTPBP4", "GUF1", "GXYLT1", "GYG1", "GYS1", "H1F0", "H1FX", "H2AFY", "H2AFY2", "H4C1*", "HACD3", "HACL1", "HADH", "HADHA", "HADHB", "HARS2", "HAT1", "HAUS1", "HAUS3", "HAUS4", "HAUS5", "HAUS6", "HAX1", "HCCS", "HCFC1", "HDAC1", "HDAC2", "HDHD2", "HDHD5", "HEATR1", "HEBP1", "HECTD1", "HECTD3", "HEXA", "HEXB", "HGH1", "HGS", "HIBADH", "HIBCH", "HINT2", "HIRA", "HIRIP3", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HM13", "HMBS", "HMCES", "HMGA1", "HMGB1", "HMGB3", "HMGCL", "HMGCR", "HMGCS1", "HMGN2", "HMMR", "HMOX1", "HMOX2", "HNRNPA1", "HNRNPA2B1", "HNRNPC", "HNRNPK", "HNRNPL", "HNRNPLL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HP1BP3", "HPRT1", "HPS6", "HS2ST1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSD17B7", "HSDL1", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA13", "HSPA14", "HSPA1B", "HSPA2", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPD1", "HSPE1", "HSPH1", "HTATSF1", "HTT", "HYOU1", "IARS", "IARS2", "ICMT", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDH3G", "IDI1", "IFIT5", "IFT27", "IFT81", "IGBP1", "IGF2BP2", "IK", "IKBIP", "ILF3", "ILKAP", "ILVBL", "IMMT", "IMP3", "IMP4", "IMPAD1", "IMPDH1", "IMPDH2", "INA", "INF2", "INPP4A", "INTS1", "INTS14", "INTS2", "INTS3", "INTS7", "INTS8", "INTS9", "IPO4", "IPO5", "IQCB1", "IRGQ", "IRS4", "ISG20L2", "IST1", "ISY1", "ISYNA1", "ITCH", "ITGB1", "ITM2C", "ITPA", "ITPK1", "ITSN2", "IVD", "JAGN1", "JPT2", "JUP", "KARS", "KDELR1", "KDM1A", "KDM3B", "KDSR", "KHDRBS1", "KHDRBS3", "KIAA0319L", "KIAA0368", "KIAA0391", "KIAA1147", "KIAA1468", "KIAA2013", "KIF14", "KIF18A", "KIF18B", "KIF1A", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF3A", "KIF5B", "KIFBP", "KIN", "KLC1", "KLC4", "KMT2A", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNA6", "KPNB1", "KRI1", "KRR1", "KTN1", "KYAT3", "L3HYPDH", "LAMP1", "LAMP2", "LAMTOR1", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LAS1L", "LBR", "LDAH", "LDHA", "LDHB", "LEMD3", "LETM1", "LGALS3", "LGMN", "LIG1", "LIG3", "LIMA1", "LIN9", "LIPA", "LLGL1", "LLPH", "LMF2", "LNPEP", "LNPK", "LONP1", "LRPAP1", "LRPPRC", "LRRC47", "LSM12", "LSM2", "LSM4", "LSM6", "LSM7", "LSS", "LTA4H", "LTN1", "LTV1", "LUC7L", "LUC7L2", "LUC7L3", "LYAR", "LZTFL1", "M6PR", "MACF1", "MAEA", "MAGED2", "MAGT1", "MAK16", "MALT1", "MANF", "MAP1A", "MAP1B", "MAP1S", "MAP4", "MAP7D1", "MAPK1", "MAPK14", "MAPRE1", "MAPRE2", "MARS", "MARS2", "MAT2A", "MAT2B", "MAU2", "MAVS", "MBD3", "MBOAT7", "MCCC2", "MCL1", "MCM10", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCMBP", "MCU", "MCUB", "MCUR1", "MDH1", "MDH2", "MDN1", "ME1", "ME2", "MECP2", "MED14", "MED17", "MED22", "MED23", "MED24", "MED4", "MEPCE", "MESD", "METAP1", "METAP2", "METTL3", "METTL9", "MFN1", "MFN2", "MFSD10", "MFSD3", "MFSD5", "MGEA5", "MGST2", "MGST3", "MICU1", "MIEF1", "MIF", "MIGA1", "MINDY3", "MINPP1", "MIPEP", "MKRN2", "MLEC", "MMAB", "MMS19", "MOCOS", "MOGS", "MON2", "MORF4L1", "MORF4L2", "MOV10", "MPC2", "MPG", "MPHOSPH10", "MPHOSPH6", "MPI", "MPST", "MPV17", "MPV17L2", "MRE11", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL14", "MRPL15", "MRPL17", "MRPL19", "MRPL2", "MRPL20", "MRPL21", "MRPL22", "MRPL24", "MRPL28", "MRPL3", "MRPL37", "MRPL38", "MRPL40", "MRPL41", "MRPL43", "MRPL44", "MRPL46", "MRPL47", "MRPL48", "MRPL49", "MRPL50", "MRPL53", "MRPL9", "MRPS11", "MRPS16", "MRPS18A", "MRPS22", "MRPS23", "MRPS25", "MRPS27", "MRPS28", "MRPS30", "MRPS31", "MRPS33", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRPS9", "MRRF", "MRTO4", "MSH2", "MSH3", "MSH6", "MSN", "MTA1", "MTA2", "MTAP", "MTBP", "MTDH", "MTHFD1", "MTHFD1L", "MTHFD2", "MTHFS", "MTMR14", "MTMR2", "MTMR6", "MTO1", "MTOR", "MTR", "MTX1", "MTX2", "MTX3", "MVD", "MYBBP1A", "MYCBP", "MYDGF", "MYEF2", "MYG1", "MYO18A", "NAA10", "NAA15", "NAA25", "NAA35", "NAA40", "NAE1", "NAF1", "NAGLU", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NAPG", "NARS", "NAT10", "NAXE", "NBN", "NCAPD2", "NCAPD3", "NCAPG", "NCAPG2", "NCAPH", "NCBP1", "NCBP3", "NCDN", "NCEH1", "NCKAP1", "NCKIPSD", "NCLN", "NCSTN", "ND1", "NDC1", "NDC80", "NDRG3", "NDUFA13", "NDUFA4", "NDUFAF3", "NDUFAF7", "NDUFB10", "NDUFB4", "NDUFB5", "NDUFB6", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS7", "NDUFS8", "NDUFV1", "NDUFV2", "NEDD4L", "NEFL", "NEFM", "NELFB", "NELFCD", "NELFE", "NES", "NF1", "NFKBIL1", "NFS1", "NFXL1", "NHP2", "NIP7", "NIPBL", "NLN", "NME1", "NME2", "NMT1", "NNT", "NOB1", "NOC2L", "NOC3L", "NOC4L", "NOL10", "NOL11", "NOL6", "NOL7", "NOL9", "NOP14", "NOP16", "NOP2", "NOP53", "NOP56", "NOP58", "NOP9", "NOSIP", "NOTCH2", "NPC1", "NPC2", "NPEPPS", "NPLOC4", "NPM1", "NRDE2", "NRP1", "NSA2", "NSF", "NSMCE2", "NSUN2", "NT5C2", "NT5C3A", "NT5C3B", "NT5DC1", "NT5DC2", "NTHL1", "NTMT1", "NTPCR", "NUB1", "NUBP2", "NUBPL", "NUCB1", "NUCB2", "NUCKS1", "NUDC", "NUDCD1", "NUDCD2", "NUDCD3", "NUDT1", "NUDT21", "NUFIP2", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP160", "NUP188", "NUP205", "NUP210", "NUP214", "NUP35", "NUP37", "NUP50", "NUP54", "NUP58", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NUSAP1", "NUTF2", "NXF1", "OAT", "OCIAD1", "OCLN", "ODR4", "OGDH", "OGFOD3", "OGT", "OLA1", "OPA1", "OPA3", "ORC2", "ORC3", "ORC5", "OSBP", "OSBPL11", "OSBPL1A", "OSBPL6", "OSBPL8", "OSBPL9", "OSGEP", "OTUB1", "OXA1L", "OXSR1", "P3H1", "P3H4", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PAF1", "PAFAH1B1", "PAK2", "PANK4", "PAPOLA", "PAPSS1", "PARG", "PARK7", "PARN", "PATL1", "PBDC1", "PBRM1", "PC", "PCBD1", "PCM1", "PCMT1", "PCNA", "PCYOX1", "PDAP1", "PDCD11", "PDCD5", "PDCD6IP", "PDHA1", "PDHB", "PDHX", "PDIA3", "PDIA4", "PDIA6", "PDK1", "PDK3", "PDLIM1", "PDP1", "PDS5A", "PDS5B", "PDSS2", "PDXDC1", "PDZD8", "PEBP1", "PECR", "PELO", "PES1", "PEX11B", "PEX14", "PEX19", "PEX3", "PFAS", "PFDN2", "PFDN4", "PFDN5", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGM3", "PGP", "PHB", "PHB2", "PHF10", "PHF5A", "PHGDH", "PHIP", "PHKA1", "PHKB", "PI4K2A", "PI4KA", "PI4KB", "PICALM", "PIGG", "PIGK", "PIGS", "PIGT", "PIGU", "PIK3C2A", "PIK3R4", "PIN4", "PIP4K2C", "PIR", "PISD", "PITHD1", "PITPNA", "PITPNB", "PKM", "PKMYT1", "PLA2G15", "PLBD2", "PLCG1", "PLEC", "PLIN3", "PLRG1", "PLS3", "PLXNB2", "PM20D2", "PMPCA", "PMPCB", "PMVK", "PNKP", "PNN", "PNO1", "PNP", "PNPT1", "POFUT1", "POLA1", "POLA2", "POLD1", "POLD2", "POLE", "POLE2", "POLG", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2A", "POLR2B", "POLR2D", "POLR2E", "POLR2G", "POLR2L", "POLR3A", "POLR3B", "POLR3C", "POLRMT", "PON2", "POP1", "POP4", "POR", "PPA1", "PPA2", "PPAN", "PPAT", "PPFIA1", "PPHLN1", "PPIE", "PPIH", "PPIL4", "PPM1G", "PPME1", "PPOX", "PPP1CA", "PPP2R1A", "PPP2R2A", "PPP2R5D", "PPP2R5E", "PPP3CA", "PPP4R1", "PPP5C", "PPP6R3", "PPT1", "PPWD1", "PRAF2", "PRC1", "PRCC", "PRCP", "PRDX2", "PRDX5", "PRDX6", "PREB", "PREP", "PREPL", "PRIM1", "PRIM2", "PRKACA", "PRKAG1", "PRKAR1A", "PRKAR2A", "PRKCB", "PRKCSH", "PRMT1", "PRMT3", "PRMT5", "PRMT9", "PRPF19", "PRPF3", "PRPF31", "PRPF38B", "PRPF40A", "PRPF6", "PRPF8", "PRPS2", "PRPSAP1", "PRPSAP2", "PRRC1", "PRRC2A", "PRRC2B", "PRRC2C", "PSAP", "PSAT1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD6", "PSMD7", "PSMD8", "PSME1", "PSME2", "PSME3", "PSME4", "PSMG1", "PSMG2", "PSMG3", "PTBP1", "PTBP2", "PTCD3", "PTDSS1", "PTDSS2", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTPA", "PTPN1", "PTPN11", "PTPN23", "PTRH2", "PUF60", "PUM3", "PURA", "PUS1", "PUS7", "PUS7L", "PWP1", "PWP2", "PXMP2", "PXN", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QDPR", "QKI", "QRSL1", "QSOX2", "QTRT2", "R3HCC1", "RAB10", "RAB12", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB1B", "RAB23", "RAB24", "RAB2A", "RAB34", "RAB35", "RAB3B", "RAB3GAP1", "RAB3GAP2", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RAB8A", "RAB9A", "RABGAP1", "RABGGTA", "RABL6", "RAC1", "RACK1", "RAD18", "RAD21", "RAD23A", "RAD23B", "RAD50", "RAD54L2", "RAE1", "RAI14", "RALA", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP6", "RAP1GDS1", "RAPGEF2", "RARS", "RARS2", "RAVER1", "RBBP5", "RBBP6", "RBM10", "RBM17", "RBM22", "RBM26", "RBM27", "RBM39", "RBM45", "RBM47", "RBM5", "RBM6", "RBM8A", "RBPJ", "RCC2", "RCL1", "RDH11", "RDH13", "RDH14", "RDX", "RECQL", "REEP4", "REEP5", "RER1", "REXO2", "REXO4", "RFC1", "RFT1", "RHEB", "RHOG", "RHOT1", "RHOT2", "RIDA", "RIF1", "RINT1", "RNASEH2A", "RNASET2", "RNF2", "RNF20", "RNF40", "RNMT", "RNPEP", "ROBO1", "ROCK1", "ROCK2", "RP2", "RPA1", "RPA2", "RPAP1", "RPF1", "RPF2", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPN1", "RPN2", "RPP30", "RPP38", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS26", "RPS28", "RPS29", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RPTOR", "RRAS2", "RRBP1", "RRM1", "RRM2", "RRP1", "RRP15", "RRP1B", "RRP36", "RRP8", "RRP9", "RRS1", "RSBN1", "RSF1", "RSL1D1", "RSL24D1", "RSPRY1", "RTCA", "RTCB", "RTFDC1", "RTN4IP1", "RTRAF", "RUVBL1", "RUVBL2", "S100A11", "S100A13", "SAE1", "SAFB", "SAFB2", "SAMM50", "SAP130", "SAP18", "SAP30BP", "SAR1A", "SAR1B", "SARM1", "SARS", "SARS2", "SART1", "SBDS", "SBNO1", "SCAF1", "SCAMP1", "SCAMP2", "SCAMP3", "SCAMP4", "SCARB1", "SCARB2", "SCD", "SCFD1", "SCFD2", "SCO1", "SCO2", "SCPEP1", "SCRN1", "SDAD1", "SDF4", "SDHA", "SDHB", "SDHC", "SDR39U1", "SEC11A", "SEC16A", "SEC22B", "SEC23A", "SEC23B", "SEC31A", "SEC61A1", "SEC61B", "SEC62", "SEC63", "SEH1L", "SENP3", "SEPT11", "SEPT2", "SEPT7", "SEPT9", "SERBP1", "SERPINB6", "SERPINH1", "SET", "SETD1A", "SETD2", "SETD3", "SETDB1", "SF1", "SF3A1", "SF3A3", "SF3B1", "SFSWAP", "SFXN1", "SFXN2", "SFXN4", "SGF29", "SGPL1", "SH3GL1", "SH3GLB1", "SHCBP1", "SHMT1", "SHMT2", "SHTN1", "SIGMAR1", "SIN3A", "SKA1", "SKA3", "SKIV2L", "SKIV2L2", "SKP1", "SLC12A2", "SLC12A9", "SLC16A1", "SLC19A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A12", "SLC25A13", "SLC25A16", "SLC25A17", "SLC25A19", "SLC25A21", "SLC25A24", "SLC25A25", "SLC25A3", "SLC25A32", "SLC25A4", "SLC25A44", "SLC25A5", "SLC25A6", "SLC27A4", "SLC33A1", "SLC35A4", "SLC35B2", "SLC35F2", "SLC39A14", "SLC3A2", "SLC4A2", "SLC5A6", "SLC7A1", "SLC9A3R1", "SLFN11", "SLK", "SLMAP", "SMARCA4", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC5", "SMCHD1", "SMG1", "SMG5", "SMPD4", "SMS", "SMU1", "SND1", "SNRPA1", "SNRPC", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNU13", "SNW1", "SNX1", "SNX17", "SNX19", "SNX2", "SNX27", "SNX5", "SNX6", "SNX9", "SOAT1", "SOD2", "SON", "SORD", "SPAG5", "SPAG9", "SPART", "SPATS2L", "SPC25", "SPCS2", "SPCS3", "SPDL1", "SPECC1L", "SPNS1", "SPOUT1", "SPPL2A", "SPR", "SPTBN1", "SQLE", "SRM", "SRP14", "SRP54", "SRP68", "SRP72", "SRP9", "SRPRB", "SRRT", "SRSF10", "SRSF11", "SSB", "SSBP1", "SSR1", "SSR4", "SSRP1", "STAG1", "STAG2", "STAT1", "STAT3", "STIP1", "STMN1", "STOM", "STOML2", "STRBP", "STRIP1", "STT3A", "STT3B", "STUB1", "STX10", "STX12", "STX16", "STX4", "STX7", "STX8", "STXBP2", "STXBP3", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGP2", "SUGT1", "SUN1", "SUN2", "SUPT16H", "SUPT3H", "SUPT5H", "SUPT6H", "SURF6", "SV2A", "SYMPK", "SYNCRIP", "SYNE2", "SYNGR2", "SYS1", "TAB1", "TACC3", "TAF15", "TAF6", "TAGLN2", "TALDO1", "TAMM41", "TAP1", "TAP2", "TARBP1", "TARS", "TARS2", "TARSL2", "TBCA", "TBCD", "TBCE", "TBL1XR1", "TBL2", "TCEA1", "TCERG1", "TCOF1", "TCP1", "TCP11L1", "TECR", "TEFM", "TERF2IP", "TES", "TEX10", "TFB1M", "TFG", "TFIP11", "TFRC", "TGFBRAP1", "THOC1", "THOC2", "THOC3", "THOC5", "THOC6", "THOP1", "THRAP3", "THUMPD1", "TIGAR", "TIMM17B", "TIMM23", "TIMM44", "TIMM50", "TIMM8B", "TJP1", "TJP2", "TK1", "TLE3", "TLK2", "TM9SF2", "TM9SF3", "TM9SF4", "TMA16", "TMCO1", "TMED10", "TMED2", "TMED7", "TMED9", "TMEM109", "TMEM11", "TMEM115", "TMEM126A", "TMEM14C", "TMEM161A", "TMEM167A", "TMEM19", "TMEM192", "TMEM199", "TMEM201", "TMEM205", "TMEM214", "TMEM230", "TMEM259", "TMEM33", "TMEM43", "TMEM65", "TMEM87A", "TMEM97", "TMLHE", "TMOD3", "TMX2", "TNKS1BP1", "TNPO1", "TNPO2", "TOE1", "TOMM20", "TOMM22", "TOMM40", "TOMM5", "TOP1", "TOP2A", "TOP2B", "TOR1A", "TOR1AIP1", "TOR1AIP2", "TOR1B", "TOX4", "TP53", "TPD52", "TPD52L2", "TPI1", "TPM3", "TPM4", "TPP2", "TPT1", "TPX2", "TRABD", "TRAF2", "TRAP1", "TRAPPC4", "TRAPPC5", "TRIM28", "TRIO", "TRIP12", "TRIP13", "TRIP4", "TRIR", "TRMT1", "TRMT10C", "TRMT11", "TRMT1L", "TRMT2A", "TRMT6", "TRMU", "TROVE2", "TRRAP", "TRUB1", "TSFM", "TSN", "TSNAX", "TSPAN3", "TSPAN6", "TSPO", "TSR1", "TST", "TTC19", "TTC26", "TTC27", "TTC37", "TTC38", "TTK", "TTLL12", "TTYH3", "TUBB", "TUBB2A", "TUBB2B", "TUBB3", "TUBB4A", "TUBB6", "TUBGCP2", "TUBGCP3", "TUFM", "TWF2", "TWNK", "TXLNA", "TXLNG", "TXNDC12", "TXNDC15", "TXNDC17", "TXNDC9", "TXNRD1", "TYMS", "U2AF1", "U2AF2", "UAP1", "UBA1", "UBA2", "UBA3", "UBA6", "UBAP2L", "UBE3A", "UBE3C", "UBE4A", "UBFD1", "UBR2", "UBR4", "UBXN7", "UCHL5", "UCK2", "UFC1", 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b/interpro_homologous_superfamily/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..d768a351efa36a76d8465ca4143e86539bcd8083 --- /dev/null +++ b/interpro_homologous_superfamily/df_merge.tsv @@ -0,0 +1,9 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Mitochondrial carrier domain superfamily [IPR023395] 18 23 3.713768788843645 0.0002041953667 9.148058252427184 20.71359223300971 2.0411027534642088 0.1411881998864352 5.368907349966936 1.8276489510009888 1.309103123363054 0.2428184236965967 2.3743516116109385e-14 0.0142466262053111 0.005693097574516 2.1183390436798366e-07 2.2571867149562812e-14 +Glycoside hydrolase superfamily [IPR017853] 7 14 2.6717323454471043 0.0075460811380587 7.094660194174757 15.565533980582524 0.5992585613623983 0.1928722204186086 2.565315823223627 1.245604487832095 1.9386029676344616 0.2695693578719223 0.0005173625269185 1.0 0.2223047329091382 0.1292409073430241 0.0001788650990257 +P-type ATPase, cytoplasmic domain N [IPR023299] 7 8 2.548795892583177 0.0108095544235906 2.941747572815534 6.145631067961165 0.9567723497044874 0.2732808833570771 1.8358630293390923 1.459204245106796 1.2102525517005158 0.2943240638910574 0.0001926635075221 1.0 0.191600110602388 0.0152248647419399 0.0004867641084232 +P-type ATPase, transmembrane domain superfamily [IPR023298] 7 8 2.548795892583177 0.0108095544235906 2.941747572815534 6.145631067961165 0.9567723497044874 0.2732808833570771 1.8358630293390923 1.459204245106796 1.2102525517005158 0.2943240638910574 0.0002517519539955 1.0 0.1993869387044997 0.0172025832638257 0.0006318501388434 +P-type ATPase, A domain superfamily [IPR008250] 7 8 2.548795892583177 0.0108095544235906 2.941747572815534 6.145631067961165 0.9567723497044874 0.2732808833570771 1.8358630293390923 1.459204245106796 1.2102525517005158 0.2943240638910574 0.0001926635075221 1.0 0.191600110602388 0.0152248647419399 0.0004867641084232 +Cytochrome b5-like heme/steroid binding domain superfamily [IPR036400] 2 5 2.3528079751849504 0.0186322532282936 2.813106796116505 6.104368932038835 1.6405397264547834 0.1100883340733615 1.2852875686886795 0.8042848477475721 1.100790504333474 0.1612592696854457 0.0113404336176026 0.0014481500629001 0.0056684159955205 0.0025975272437437 0.018020673376298 +EF-hand domain pair [IPR011992] 17 49 2.279838797816864 0.0226172510019011 13.3252427184466 49.37378640776699 0.9065364020670126 0.4404331516970506 4.9772339658485505 4.730718887980642 1.169914018421813 0.3730081256676846 0.0006710435700999 0.4596995041522239 0.0338351909830103 0.0009829630455582 3.911092841654126e-05 +Band 7/SPFH domain superfamily [IPR036013] 7 8 2.272620937461822 0.0230490327969998 3.825242718446602 7.354368932038835 0.2848798017769268 0.3662852929750465 1.8717479731706237 0.7075565364256523 1.25010454777189 0.3076860385713043 0.0065740916466848 1.0 1.0 0.0229613270793894 0.0009118158302113 diff --git a/interpro_homologous_superfamily/metrics.json b/interpro_homologous_superfamily/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..c172eb5a65f678ee2948653e8213cecb354537bc --- /dev/null +++ b/interpro_homologous_superfamily/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3221, + "annotations_size": 976, + "title": "Average number of proteins per term", + "value": 4.961065573770492 +} \ No newline at end of file diff --git a/interpro_homologous_superfamily/paths.json b/interpro_homologous_superfamily/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..6323abf597d8e65e3ec39b29b8e72bcc1d03d774 --- /dev/null +++ b/interpro_homologous_superfamily/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/interpro_homologous_superfamily/fragment/C201/C201_val_log2fc"} \ No newline at end of file diff --git a/interpro_homologous_superfamily/result.tsv b/interpro_homologous_superfamily/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..5ac7e839a2de63df8460fa949357a5266a572326 --- /dev/null +++ b/interpro_homologous_superfamily/result.tsv @@ -0,0 +1,130 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Mitochondrial carrier domain superfamily [IPR023395] 0.7950682684119263 3.713768788843645 0.0002041953667 0.1807082473273274 0.1992946778992222 23 Q9BSK2,Q9HC21,Q6NUK1,Q96H78,P12236,Q9UJS0,O75746,Q70HW3,Q9BQT8,Q9UBX3,Q9H2D1,Q9NZJ7,P16260,P53007,P12235,Q9Y6C9,Q6KCM7,Q9Y619 18 +Glycoside hydrolase superfamily [IPR017853] 0.7284361797031318 2.6717323454471043 0.0075460811380587 0.9993843944450146 0.303872384951611 14 P16278,P35573,P06280,P54802,P10253,P04062,P06865 7 +P-type ATPase, cytoplasmic domain N [IPR023299] 0.8291316526610572 2.548795892583177 0.0108095544235906 0.9999752716566612 0.303872384951611 8 P98194,Q9HD20,P20020,P05023,P16615,P35670,Q04656 7 +P-type ATPase, transmembrane domain superfamily [IPR023298] 0.8291316526610572 2.548795892583177 0.0108095544235906 0.9999752716566612 0.303872384951611 8 P98194,Q9HD20,P20020,P05023,P16615,P35670,Q04656 7 +P-type ATPase, A domain superfamily [IPR008250] 0.8291316526610572 2.548795892583177 0.0108095544235906 0.9999752716566612 0.303872384951611 8 P98194,Q9HD20,P20020,P05023,P16615,P35670,Q04656 7 +Cytochrome b5-like heme/steroid binding domain superfamily [IPR036400] 0.8952141059425103 2.3528079751849504 0.0186322532282936 0.9999999893385124 0.303872384951611 5 O15173,O43169 2 +EF-hand domain pair [IPR011992] 0.5063346213648475 2.279838797816864 0.0226172510019011 0.9999999997990364 0.303872384951611 49 Q14257,Q8IXI1,P41208,Q9NWM8,O43852,Q6NUK1,Q9UJS0,Q02818,O95202,O75071,P80303,Q9Y680,Q9BPX6,Q99828,Q6KCM7,Q9BRK5,Q8NF37 17 +Band 7/SPFH domain superfamily [IPR036013] 0.7712418300653563 2.272620937461822 0.0230490327969998 0.9999999998694368 0.303872384951611 8 P35232,O75477,Q99623,O94905,O75955,P27105,Q14254 7 +SNARE [IPR010989] 0.7914113868109633 1.9087197083354217 0.0562982593645493 1.0 0.3563329673490745 5 O15400,O60499 2 +Glycosyl hydrolase, all-beta [IPR013780] 0.6858261155804358 1.8482466410340752 0.0645666709534558 1.0 0.3563329673490745 8 P10253,Q16706,P06280,Q9BTY2 4 +Porin domain superfamily [IPR023614] 0.8765064247950722 1.8230980103737748 0.0682885478955461 1.0 0.360229177072482 4 P21796,P45880 2 +Immunoglobulin-like domain superfamily [IPR036179] 0.579661308612986 1.7969198477519446 0.0723483452121902 1.0 0.3658652068761537 14 P04439,P10321,P35613,Q08722,O75962 5 +Metallopeptidase, catalytic domain superfamily [IPR024079] 0.8628369013343844 1.7676797200016583 0.0771144622058108 1.0 0.3749443086494639 4 P42892,P52888 2 +Tetraspanin, EC2 domain superfamily [IPR008952] 0.990990990990991 1.7260687507912102 0.0843350449000084 1.0 0.3904096682752182 2 O43657 1 +Rhomboid-like superfamily [IPR035952] 0.849311805835463 1.7126213659578065 0.0867822199590264 1.0 0.3926123221132222 4 Q6NTF9,Q9GZP9 2 +Haem oxygenase-like, multi-helical [IPR016084] 0.9872631251941596 1.7108426148126807 0.0871101703964414 1.0 0.3926123221132222 2 P09601 1 +Aminopeptidase N-like , N-terminal domain superfamliy [IPR042097] 0.7085535341000001 1.6936233050770766 0.0903368866443727 1.0 0.3946212565587739 6 Q9NZ08,Q6P179,P09960,Q9UIQ6 4 +Peptidase M4/M1, CTD superfamily [IPR027268] 0.7085535341000001 1.6936233050770766 0.0903368866443727 1.0 0.3946212565587739 6 Q9NZ08,Q6P179,P09960,Q9UIQ6 4 +Cytochrome P450 superfamily [IPR036396] 0.9826032929481194 1.6918005263839195 0.0906840132117754 1.0 0.3946212565587739 2 Q6UW02 1 +Cytochrome c oxidase, subunit VIIa superfamily [IPR036539] 0.9487418452935664 1.5531962707217488 0.1203762520063844 1.0 0.4519555521412765 2 P14406 1 +Histidine phosphatase superfamily [IPR029033] 0.6770718684758228 1.543965218353807 0.1225967589175243 1.0 0.4519555521412765 6 P11117 1 +HAD-like superfamily [IPR036412] 0.4869716931500084 1.532795468902281 0.1253262574186646 1.0 0.4519555521412765 21 Q04656,P98194,P23634,Q9HD20,Q9H857,P20020,P05023,Q3ZCQ8,P35670,P16615 10 +HAD superfamily [IPR023214] 0.4869716931500084 1.532795468902281 0.1253262574186646 1.0 0.4519555521412765 21 Q04656,P98194,P23634,Q9HD20,Q9H857,P20020,P05023,Q3ZCQ8,P35670,P16615 10 +Tim10-like domain superfamily [IPR035427] 0.9419074246660448 1.5251926007434566 0.1272110656008729 1.0 0.4519555521412765 2 Q9Y5J9 1 +Chloride channel, core [IPR014743] 0.9316557937247584 1.4831856995812944 0.1380250795744433 1.0 0.4682237890435329 2 P51798 1 +Metalloenzyme, LuxS/M16 peptidase-like [IPR011249] 0.6308954808508817 1.4376682590267889 0.1505282032368788 1.0 0.4848697239577352 7 P22695,Q5JRX3,Q10713,O43847 4 +FAD/NAD(P)-binding domain superfamily [IPR036188] 0.4773693563193245 1.4139554632224334 0.1573749795147827 1.0 0.4983404388226115 20 O95831,Q9H9P8,Q96CU9,Q14534,P09622,Q9UHG3 6 +L27 domain superfamily [IPR036892] 0.6783437872012215 1.402541419542051 0.1607536309524642 1.0 0.4983404388226115 5 Q14168,Q12959 2 +Galactose mutarotase-like domain superfamily [IPR011013] 0.6782822539760995 1.402260958652343 0.1608373342511502 1.0 0.4983404388226115 5 P10253,Q16706 2 +DHS-like NAD/FAD-binding domain superfamily [IPR029035] 0.6751732925935522 1.3880856040613194 0.1651109796821153 1.0 0.5035884880304518 5 Q13423,A1L0T0 2 +Nucleophile aminohydrolases, N-terminal [IPR029055] 0.4829915822522574 1.367396027600375 0.1715012067929182 1.0 0.5088948795818181 18 P49721,Q9UJ14 2 +FAD-binding, type PCMH, subdomain 2 [IPR016169] 0.8853681267474314 1.2938707070689297 0.1957100842318866 1.0 0.5504698622775831 2 Q15392 1 +FAD-binding, type PCMH-like superfamily [IPR036318] 0.8853681267474314 1.2938707070689297 0.1957100842318866 1.0 0.5504698622775831 2 Q15392 1 +G protein alpha subunit, helical insertion [IPR011025] 0.6492103556114117 1.269373185112599 0.2043079953043509 1.0 0.5617031082170325 5 P50148,P04899 2 +Lamin tail domain superfamily [IPR036415] 0.8666873834679857 1.256193082651741 0.2090459741108126 1.0 0.5683255452149112 3 P02545,P20700 2 +LEM/LEM-like domain superfamily [IPR011015] 0.6425873827676054 1.2390165004114615 0.2153393874769826 1.0 0.5742383666052872 5 P50402,P42167 2 +Ricin B-like lectins [IPR035992] 0.6422386703949489 1.2374175763380335 0.2159320968691109 1.0 0.574249936087881 5 Q8N4A0,Q10472,Q9UBG0 3 +NAP-like superfamily [IPR037231] 0.8592293349906737 1.227503388540878 0.2196334490025562 1.0 0.576815351696507 3 Q01105,Q99733 2 +UBA-like superfamily [IPR009060] 0.4494279408542958 1.2088800800232404 0.2267089201379495 1.0 0.5801417164164911 20 Q96RU2,Q9UPU5,Q9NRR5,P54725,Q04323,Q9Y5A7,Q96CS3 7 +Choline/Carnitine o-acyltransferase, domain 2 [IPR042231] 0.8642435538987245 1.207957361603152 0.2270636635974381 1.0 0.5801417164164911 2 P23786 1 +Beta-hexosaminidase-like, domain 2 [IPR029018] 0.8521549816925114 1.2003195982723691 0.2300152411888132 1.0 0.5837314096047738 3 P54802 1 +NAD(P)-binding domain superfamily [IPR036291] 0.3399493587101904 1.150711153108969 0.2498510866032728 1.0 0.6142434773924289 68 P48163,Q3SXM5,Q8WWV3,Q9Y394,O43175,P40939,Q8N4Q0,Q8NBN7,Q53GQ0,Q8NBX0,Q96LJ7,Q13423,Q9NRG7,Q06136,Q16836,Q6YN16 16 +Heavy metal-associated domain superfamily [IPR036163] 0.8384089496581575 1.1476050357482803 0.2511316499841307 1.0 0.6149840237775496 3 P35670,Q04656 2 +Nucleotide-diphospho-sugar transferases [IPR029044] 0.4333066756770696 1.131420080799514 0.2578783235191004 1.0 0.6168854013594167 21 Q13144,Q8N4A0,Q16739,Q8N6G5,Q10472 5 +Six-hairpin glycosidase superfamily [IPR008928] 0.7081131488964791 1.1292506137907268 0.2587921278800382 1.0 0.6169745203426482 4 Q13724,P35573,P46020 3 +Neurolysin/Thimet oligopeptidase, domain 2 [IPR024077] 0.8333129830004438 1.1281053567866146 0.2592754271235669 1.0 0.6169745203426482 3 P52888 1 +Dimeric alpha-beta barrel [IPR011008] 0.8434296365330837 1.1238508426070888 0.2610763083007312 1.0 0.6169745203426482 2 O75323 1 +Glycoside hydrolase 38, N-terminal domain superfamily [IPR027291] 0.8306927617272439 1.0727379328858244 0.2833887156997887 1.0 0.6358330724666524 2 Q16706 1 +Glycoside hydrolase family 38, central domain superfamily [IPR037094] 0.8306927617272439 1.0727379328858244 0.2833887156997887 1.0 0.6358330724666524 2 Q16706 1 +Glycoside hydrolase families 57/38, central domain superfamily [IPR028995] 0.8306927617272439 1.0727379328858244 0.2833887156997887 1.0 0.6358330724666524 2 Q16706 1 +Glycoside hydrolase/deacetylase, beta/alpha-barrel [IPR011330] 0.8306927617272439 1.0727379328858244 0.2833887156997887 1.0 0.6358330724666524 2 Q16706 1 +Prefoldin [IPR009053] 0.688495200521528 1.0481081771228655 0.2945887692741586 1.0 0.6490262727123676 4 Q9UHV9,Q99471 2 +PX domain superfamily [IPR036871] 0.4872016239451243 1.0135524810196284 0.310796341903953 1.0 0.6696186086054263 11 Q9Y5X3,Q92543,O60749,Q96L92 4 +Glutathione S-transferase, C-terminal domain superfamily [IPR036282] 0.4402957873577203 0.999626658281024 0.3174912171222379 1.0 0.6795426050686496 16 Q8TB36,Q9H7Z7,Q13505 3 +Isoprenoid synthase domain superfamily [IPR008949] 0.7824735860783046 0.9355091067001184 0.3495259923859861 1.0 0.6976224306108845 3 P37268,P14324 2 +C-type lectin fold [IPR016187] 0.7918608263435732 0.9192215261229748 0.3579797140198364 1.0 0.6984901512300672 2 Q5KU26 1 +C-type lectin-like/link domain superfamily [IPR016186] 0.7918608263435732 0.9192215261229748 0.3579797140198364 1.0 0.6984901512300672 2 Q5KU26 1 +Tubulin, C-terminal [IPR023123] 0.5480559875583171 0.918693609223736 0.358255853478598 1.0 0.6984901512300672 6 Q13509,P07437,P04350,Q9BVA1,Q13885 5 +Tubulin/FtsZ-like, C-terminal domain [IPR037103] 0.5480559875583171 0.918693609223736 0.358255853478598 1.0 0.6984901512300672 6 Q13509,P07437,P04350,Q9BVA1,Q13885 5 +Tubulin/FtsZ, C-terminal [IPR008280] 0.5480559875583171 0.918693609223736 0.358255853478598 1.0 0.6984901512300672 6 Q13509,P07437,P04350,Q9BVA1,Q13885 5 +AH/BAR domain superfamily [IPR027267] 0.4493453458685453 0.899621756726524 0.3683215748659467 1.0 0.6985543452204228 13 Q9Y371,Q68EM7,Q9UNH7,Q9Y5X3,O60749 5 +Proteasome activator PA28, N-terminal domain superfamily [IPR036996] 0.7704316739641228 0.8906083351247229 0.3731393260378355 1.0 0.6985543452204228 3 P61289 1 +Proteasome activator superfamily [IPR036252] 0.7704316739641228 0.8906083351247229 0.3731393260378355 1.0 0.6985543452204228 3 P61289 1 +Proteasome activator PA28, C-terminal domain superfamily [IPR036997] 0.7704316739641228 0.8906083351247229 0.3731393260378355 1.0 0.6985543452204228 3 P61289 1 +Alkaline-phosphatase-like, core domain superfamily [IPR017850] 0.7678682411435475 0.8810962999043792 0.3782656997663518 1.0 0.6991963073219735 3 Q5H8A4,P34059 2 +Translin superfamily [IPR036081] 0.7757067412239835 0.8566978349464635 0.391611900187875 1.0 0.7064939271411572 2 Q99598 1 +Translin, C-terminal [IPR016069] 0.7757067412239835 0.8566978349464635 0.391611900187875 1.0 0.7064939271411572 2 Q99598 1 +Translin, N-terminal [IPR016068] 0.7757067412239835 0.8566978349464635 0.391611900187875 1.0 0.7064939271411572 2 Q99598 1 +Regulatory factor, effector binding domain superfamily [IPR011256] 0.7651444547996175 0.8163504289193378 0.4142997396859615 1.0 0.7312053271853499 2 Q9Y6I9 1 +MFS transporter superfamily [IPR036259] 0.4667829065159449 0.7918691813641169 0.4284369584889704 1.0 0.7344896406444342 9 Q9H2V7,O00400,Q96ES6,Q7L0J3 4 +Peptidase M41-like [IPR037219] 0.7576887232059635 0.7881535767310349 0.4306068797053526 1.0 0.7344896406444342 2 Q96TA2 1 +XPC-binding domain superfamily [IPR036353] 0.7468157812985301 0.7474934940336919 0.4547657285393538 1.0 0.753567658836009 2 P54725 1 +FAD/NAD-linked reductase, dimerisation domain superfamily [IPR016156] 0.6126668113354306 0.7405267642365783 0.4589804273840023 1.0 0.753840477449999 4 P09622 1 +Alpha/Beta hydrolase fold [IPR029058] 0.368639642592891 0.7118070429605704 0.476584270827038 1.0 0.7663035392540183 25 Q4J6C6,Q9HB40,P50897,Q6PIU2,Q9H6V9,P42785,Q8NCG7,Q9NUJ1,P10619,Q8N2K0,Q9H3G5 11 +Six-hairpin glycosidase-like superfamily [IPR012341] 0.7197016780608962 0.7061880099586993 0.4800712257212975 1.0 0.7696175376945349 3 P46020,O43399 2 +Thioredoxin-like superfamily [IPR036249] 0.346595502150569 0.7059448761445246 0.480222418499971 1.0 0.7696175376945349 47 Q96JJ7,Q96J42,Q8TB36,Q9Y320,Q9H3N1,O75880,Q9H7Z7,O43819,Q9Y2G8,Q8TED1,Q6ZRP7 11 +MHC class I-like antigen recognition-like superfamily [IPR037055] 0.7097576134244725 0.6711850637814171 0.5021026425207611 1.0 0.7766683515345205 3 P04439,P10321 2 +MHC classes I/II-like antigen recognition protein [IPR011162] 0.7097576134244725 0.6711850637814171 0.5021026425207611 1.0 0.7766683515345205 3 P04439,P10321 2 +EB1, C-terminal domain superfamily [IPR036133] 0.7247592420006196 0.6669032182584577 0.5048339551430552 1.0 0.7771576344158073 2 Q15555 1 +ERO1-like superfamily [IPR037192] 0.7173035104069541 0.6403027281491994 0.5219758074580092 1.0 0.7866089356221753 2 Q96HE7 1 +RmlC-like jelly roll fold [IPR014710] 0.4353045979783072 0.6179819435670362 0.5365872411850021 1.0 0.7893929108898898 9 Q6P4Q7,P38435,O00625 3 +GOLD domain superfamily [IPR036598] 0.6923829044160771 0.6111655043715388 0.5410900178128446 1.0 0.7893929108898898 3 Q15363 1 +Class II aldolase/adducin N-terminal domain superfamily [IPR036409] 0.7036346691519045 0.5924774241606209 0.5535309339288446 1.0 0.7987453343347116 2 Q9UEY8 1 +G-protein gamma-like domain superfamily [IPR036284] 0.7027027027026913 0.5892635231708985 0.5556845102594972 1.0 0.7987453343347116 2 P63218 1 +EXOC6/PINT-1/Sec15/Tip20, C-terminal, domain 2 [IPR042044] 0.6881018949984431 0.539751013986987 0.589368753692322 1.0 0.817358627574705 2 Q6NUQ1 1 +SCP2 sterol-binding domain superfamily [IPR036527] 0.670913610938465 0.5392931259229978 0.5896846112552216 1.0 0.817358627574705 3 P51659,Q6YN16 2 +ABC transporter type 1, transmembrane domain superfamily [IPR036640] 0.4140323880298475 0.5034339640003401 0.6146591974910227 1.0 0.8348048524800559 9 Q03519,Q9NRK6,P28288,Q03518,Q9NP58,Q9NUT2 6 +GINS, helical bundle-like domain superfamily [IPR036224] 0.6597478592688477 0.5030520809050271 0.6149276560076489 1.0 0.8348048524800559 3 Q9Y248 1 +KA1 domain/Ssp2, C-terminal [IPR028375] 0.6688412550481487 0.4770466569105189 0.6333288982507417 1.0 0.8506973357144644 2 Q13131 1 +SH3-like domain superfamily [IPR036028] 0.3306757858988727 0.4267014615204836 0.6695967859060765 1.0 0.8702083396062992 35 Q14168,Q96PC5,Q5JRA6,Q9Y371 4 +RmlC-like cupin domain superfamily [IPR011051] 0.5184030233271051 0.3923643870694002 0.6947889956875166 1.0 0.8859526133162843 4 P38435 1 +Death-like domain superfamily [IPR011029] 0.4505597014925288 0.3919441907377778 0.6950994504524837 1.0 0.8859526133162843 5 Q13546,Q96FV9,Q12955,Q7Z434 4 +Cobalamin-binding domain superfamily [IPR036724] 0.6340478409443859 0.3724369350538343 0.7095675584325123 1.0 0.8959093622640776 2 P22033 1 +6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily [IPR008927] 0.3729285425900108 0.2939699988135596 0.7687808284626314 1.0 0.929777061436838 9 P40939 1 +14-3-3 domain superfamily [IPR036815] 0.3996889580093333 0.2524292623061593 0.8007092842659191 1.0 0.940423900654076 6 P62258,Q04917,P61981,P31946,P63104 5 +BRO1 domain superfamily [IPR038499] 0.586206896551714 0.2501245398995789 0.8024910389168356 1.0 0.9413837187293648 2 Q9H3S7 1 +Fibronectin type II domain superfamily [IPR036943] 0.5685582455204513 0.2454394095201115 0.8061162176030574 1.0 0.9414626485723586 3 Q9UBV2 1 +Kringle-like fold [IPR013806] 0.5685582455204513 0.2454394095201115 0.8061162176030574 1.0 0.9414626485723586 3 Q9UBV2 1 +Immunoglobulin-like fold [IPR013783] 0.3099314826776992 0.2450065390256234 0.8064513682358152 1.0 0.9414626485723586 31 Q8NHP6,P04439,Q8IZA0,P78310,P10321,O75962,Q15375,Q08722,P35613 9 +Sterile alpha motif/pointed domain superfamily [IPR013761] 0.3497231133584501 0.2309617546928553 0.8173445141015765 1.0 0.9423357857189382 11 Q6UWE0,Q9Y6Y8,Q9ULH0,Q15375 4 +Vacuolar protein sorting-associated protein 33, domain 3b [IPR043155] 0.5563839701770612 0.1881701805888756 0.8507432473552723 1.0 0.9564221604311016 2 Q9H267 1 +Aspartate decarboxylase-like domain superfamily [IPR009010] 0.5335612181479317 0.1692414659069205 0.8656067151138116 1.0 0.9600365385807728 3 P46459,Q8NB90 2 +Translation elongation factor eEF-1beta-like superfamily [IPR036219] 0.5343274308791427 0.1497879742166082 0.8809318974966938 1.0 0.9693230349005334 2 P24534 1 +Translation elongation factor EF1B/ribosomal protein S6 [IPR014717] 0.5343274308791427 0.1497879742166082 0.8809318974966938 1.0 0.9693230349005334 2 P24534 1 +CDC48 domain 2-like superfamily [IPR029067] 0.533395464429934 0.1483056432969745 0.8821015619045605 1.0 0.9695170320032106 2 P46459 1 +Cyclic nucleotide-binding-like [IPR018490] 0.3794242978899111 0.1456862918203211 0.8841690434452594 1.0 0.9706962726688112 5 P10644,Q6P4Q7 2 +Ribosomal protein L7/L12, C-terminal/adaptor protein ClpS-like [IPR014719] 0.5256290773532066 0.1363884743913467 0.8915141846407957 1.0 0.9753460412007788 2 P52815 1 +Vps16, C-terminal domain superfamily [IPR038132] 0.5243864554209323 0.1345535594239101 0.8929648617982959 1.0 0.9753460412007788 2 Q9H9C1 1 +Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid [IPR008930] 0.523143833488646 0.13273834731779 0.8944003144207961 1.0 0.9753460412007788 2 P48449 1 +p53-like tetramerisation domain superfamily [IPR036674] 0.5107353358742115 0.127394112924584 0.8986284754836575 1.0 0.9787831095831708 3 P04637 1 +Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain superfamily [IPR036784] 0.5015537600994503 0.1123489556247297 0.9105467265033436 1.0 0.9821590296307802 3 O14874,Q15120 2 +BSD domain superfamily [IPR035925] 0.5063684374029199 0.1101349393302187 0.9123023591145968 1.0 0.9821590296307802 2 Q96A49 1 +eRF1, domain 2 superfamily [IPR042226] 0.4951848400124106 0.0969822078547565 0.9227405239120394 1.0 0.9875231013183704 2 P62495 1 +Six-bladed beta-propeller, TolB-like [IPR011042] 0.3545264611700449 0.09694825398841 0.9227674881171656 1.0 0.9875231013183704 6 Q15165,Q9HDC9 2 +Oxysterol-binding protein superfamily [IPR037239] 0.3530326594090068 0.0924349787993509 0.9263524493170116 1.0 0.9891903616339204 6 P22059,Q9BZF3,Q9BXW6,Q9BZF1,Q96SU4 5 +K homology domain superfamily, prokaryotic type [IPR009019] 0.4659832246038992 0.0693578695950671 0.9447047633155784 1.0 0.9914320956946284 2 O75616 1 +K homology domain-like, alpha/beta [IPR015946] 0.4659832246038992 0.0693578695950671 0.9447047633155784 1.0 0.9914320956946284 2 O75616 1 +Quinoprotein amine dehydrogenase, beta chain-like [IPR011044] 0.4538676607641957 0.0604985163578244 0.9517585974622592 1.0 0.9947015861185656 2 A2RRP1 1 +Alpha/beta knot methyltransferases [IPR029028] 0.4530764449968997 0.0495623289235075 0.9604711668819708 1.0 0.9993815126618374 3 Q5T280,Q13395 2 +tRNA (guanine-N1-)-methyltransferase, N-terminal [IPR029026] 0.4530764449968997 0.0495623289235075 0.9604711668819708 1.0 0.9993815126618374 3 Q5T280,Q13395 2 +AF1104-like superfamily [IPR036075] 0.4265299782541188 0.0452869869413204 0.963878559713713 1.0 1.0 2 Q9NVE7 1 +Acyl transferase/acyl hydrolase/lysophospholipase [IPR016035] 0.4482597303635239 0.0447830192774704 0.9642802601662932 1.0 1.0 3 Q8IY17 1 +ESCRT assembly domain [IPR037202] 0.4187635911773765 0.0420176909004713 0.9664845952715608 1.0 1.0 2 Q9H9H4 1 +Tautomerase/MIF superfamily [IPR014347] 0.4041627834731285 0.0369324636806634 0.9705388551230087 1.0 1.0 2 P14174 1 +Sec1-like, domain 2 [IPR027482] 0.327629122588672 0.0368021009975303 0.9706427988311406 1.0 1.0 7 Q8WVM8,O00186,Q96AX1,Q15833,Q9H267,Q8WU76 6 +Sec1-like superfamily [IPR036045] 0.327629122588672 0.0368021009975303 0.9706427988311406 1.0 1.0 7 Q8WVM8,O00186,Q96AX1,Q15833,Q9H267,Q8WU76 6 +Signal recognition particle, SRP9/SRP14 subunit [IPR009018] 0.3379931655793767 0.0259265311714238 0.9793159383418308 1.0 1.0 2 P49458 1 +Sec1-like, domain 3a [IPR043127] 0.3275272161741717 0.0223661851340059 0.9821558539544072 1.0 1.0 6 Q8WVM8,O00186,Q96AX1,Q15833,Q9H267 5 +Sec1-like, domain 1 [IPR043154] 0.3275272161741717 0.0223661851340059 0.9821558539544072 1.0 1.0 6 Q8WVM8,O00186,Q96AX1,Q15833,Q9H267 5 diff --git a/interpro_homologous_superfamily/selections.json b/interpro_homologous_superfamily/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..a7385aee0076e646e77c51eeb1c5080ba3cb2dff --- /dev/null +++ b/interpro_homologous_superfamily/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["14-3-3 domain superfamily [IPR036815]", "2Fe-2S ferredoxin-like superfamily [IPR036010]", "30s ribosomal protein S13, C-terminal [IPR027437]", "4'-phosphopantetheinyl transferase domain superfamily [IPR037143]", "5'-3' exonuclease, C-terminal domain superfamily [IPR036279]", "5-formyltetrahydrofolate cyclo-ligase-like domain superfamily [IPR024185]", "50S ribosomal protein L10, insertion domain superfamily [IPR043164]", "50S ribosomal protein L30e-like [IPR029064]", "6-phosphogluconate dehydrogenase, domain 2 [IPR013328]", "6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily [IPR008927]", "AAR2, C-terminal domain superfamily [IPR038514]", "AAR2, N-terminal domain superfamily [IPR038516]", "ABC transporter type 1, transmembrane domain superfamily [IPR036640]", "ACP-like superfamily [IPR036736]", "ADF-H/Gelsolin-like domain superfamily [IPR029006]", "AF1104-like superfamily [IPR036075]", "AH/BAR domain superfamily [IPR027267]", "AICAR transformylase, duplicated domain superfamily [IPR024051]", "AICAR transformylase, insert domain superfamily [IPR024050]", "AMP-binding enzyme, C-terminal domain superfamily [IPR045851]", "ANL, N-terminal domain [IPR042099]", "ANTH domain superfamily [IPR014712]", "AP-2 complex subunit mu, C-terminal superfamily [IPR036168]", "ARFGAP/RecO-like zinc finger [IPR037278]", "ARID DNA-binding domain superfamily [IPR036431]", "ATP synthase subunit alpha, N-terminal domain-like superfamily [IPR023366]", "ATP synthase, F0 complex, subunit D superfamily, mitochondrial [IPR036228]", "ATP synthase, F1 complex, gamma subunit superfamily [IPR035968]", "ATP synthase, alpha subunit, C-terminal domain superfamily [IPR038376]", "ATP-grasp fold, subdomain 1 [IPR013815]", "ATP:guanido phosphotransferase, N-terminal domain superfamily [IPR036802]", "ATPase, F1/V1 complex, beta/alpha subunit, C-terminal [IPR024034]", "ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain superfamily [IPR036121]", "ATPase, V1 complex, subunit H, C-terminal domain superfamily [IPR038497]", "ATPase, nucleotide binding domain [IPR043129]", "Acetylglutamate kinase-like superfamily [IPR036393]", "Aconitase, domain 2 [IPR015932]", "Aconitase, iron-sulfur domain [IPR036008]", "Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 1/3 [IPR015931]", "Aconitase/3-isopropylmalate dehydratase, swivel [IPR015928]", "Actin-crosslinking [IPR008999]", "Actin-related protein 2/3 complex subunit 3 superfamily [IPR036753]", "Activator of Hsp90 ATPase, Aha1 [IPR036338]", "Acyl transferase domain superfamily [IPR001227]", "Acyl transferase/acyl hydrolase/lysophospholipase [IPR016035]", "Acyl-CoA N-acyltransferase [IPR016181]", "Acyl-CoA binding protein superfamily [IPR035984]", "Acyl-CoA dehydrogenase-like, C-terminal [IPR036250]", "Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain superfamily [IPR009100]", "Acyl-CoA dehydrogenase/oxidase, N-terminal domain superfamily [IPR037069]", "Acyl-CoA thioesterase, double hotdog domain [IPR042171]", "Adenine nucleotide alpha hydrolase-like domains [IPR023382]", "Adenosylhomocysteinase-like superfamily [IPR042172]", "Adenylate cyclase-associated CAP, C-terminal superfamily [IPR036223]", "Adenylate cyclase-associated CAP, N-terminal domain superfamily [IPR036222]", "Adenylate kinase, active site lid domain superfamily [IPR036193]", "Adenylosuccinate synthetase, domain 1 [IPR042109]", "Adenylosuccinate synthetase, domain 2 [IPR042110]", "Adenylosuccinate synthetase, domain 3 [IPR042111]", "Alanine-tRNA ligase, class IIc, anti-codon-binding domain superfamily [IPR018162]", "Aldehyde dehydrogenase, C-terminal [IPR016163]", "Aldehyde dehydrogenase, N-terminal [IPR016162]", "Aldehyde/histidinol dehydrogenase [IPR016161]", "Aldolase-type TIM barrel [IPR013785]", "Alkaline-phosphatase-like, core domain superfamily [IPR017850]", "Allosteric substrate binding domain superfamily [IPR029009]", "Alpha-D-phosphohexomutase, C-terminal domain superfamily [IPR036900]", "Alpha-D-phosphohexomutase, alpha/beta/alpha I/II/III [IPR016055]", "Alpha-catenin/vinculin-like superfamily [IPR036723]", "Alpha-glycerophosphate oxidase, C-terminal domain superfamily [IPR038299]", "Alpha-helical ferredoxin [IPR009051]", "Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain superfamily [IPR036784]", "Alpha-ketoglutarate-dependent dioxygenase AlkB-like superfamily [IPR037151]", "Alpha/Beta hydrolase fold [IPR029058]", "Alpha/beta knot methyltransferases [IPR029028]", "Amidase signature (AS) superfamily [IPR036928]", "Aminoacyl-tRNA synthetase, class I, anticodon-binding domain, subdomain 2 [IPR020751]", "Aminoacyl-tRNA synthetase, class I, anticodon-binding superfamily [IPR008925]", "Aminoacyl-tRNA synthetase, class Ia, anticodon-binding [IPR009080]", "Aminopeptidase N-like , N-terminal domain superfamliy [IPR042097]", "Amyloidogenic glycoprotein, amyloid-beta peptide superfamily [IPR037071]", "Amyloidogenic glycoprotein, copper-binding domain superfamily [IPR036669]", "Amyloidogenic glycoprotein, heparin-binding domain superfamily [IPR036454]", "Ankyrin repeat-containing domain superfamily [IPR036770]", "Annexin superfamily [IPR037104]", "Anticodon-binding domain superfamily [IPR036621]", "Antifreeze-like/N-acetylneuraminic acid synthase C-terminal domain superfamily [IPR036732]", "ApaG domain superfamily [IPR036767]", "Apyrase superfamily [IPR036258]", "ArfGAP domain superfamily [IPR038508]", "Arginyl tRNA synthetase N-terminal domain superfamily [IPR036695]", "Armadillo-like helical [IPR011989]", "Armadillo-type fold [IPR016024]", "Arp2/3 complex subunit 2/4 [IPR034666]", "Arrestin-like, C-terminal [IPR014752]", "Aspartate decarboxylase-like domain superfamily [IPR009010]", "Aspartate/ornithine carbamoyltransferase superfamily [IPR036901]", "Aspartic peptidase domain superfamily [IPR021109]", "Aspartyl/glutamyl-tRNA amidotransferase subunit B-like [IPR003789]", "Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, C-terminal, domain 2 [IPR023168]", "At2g17340, three-helix bundle domain [IPR035073]", "B30.2/SPRY domain superfamily [IPR043136]", "BAG domain superfamily [IPR036533]", "BEACH domain superfamily [IPR036372]", "BRCT domain superfamily [IPR036420]", "BRK domain superfamily [IPR037259]", "BRO1 domain superfamily [IPR038499]", "BSD domain superfamily [IPR035925]", "Bacterial exopeptidase dimerisation domain [IPR036264]", "Band 7/SPFH domain superfamily [IPR036013]", "Barrier-to-autointegration factor, BAF superfamily [IPR036617]", "Bcl-2-like superfamily [IPR036834]", "Bcr-Abl oncoprotein oligomerisation domain superfamily [IPR036481]", "Beta-grasp domain superfamily [IPR012675]", "Beta-hexosaminidase-like, domain 2 [IPR029018]", "Beta-lactamase/transpeptidase-like [IPR012338]", "Beta-trefoil domain superfamily [IPR036358]", "BolA-like superfamily [IPR036065]", "Bromo adjacent homology (BAH) domain superfamily [IPR043151]", "Bromodomain-like superfamily [IPR036427]", "C-type lectin fold [IPR016187]", "C-type lectin-like/link domain superfamily [IPR016186]", "C2 domain superfamily [IPR035892]", "CAP Gly-rich domain superfamily [IPR036859]", "CCR4-NOT subunit 1, TTP binding domain superfamily [IPR038535]", "CDC48 domain 2-like superfamily [IPR029067]", "CDP-alcohol phosphatidyltransferase, transmembrane domain [IPR043130]", "CENP-B, dimerisation domain superfamily [IPR034882]", "CH domain superfamily [IPR036872]", "CKK domain superfamily [IPR038209]", "CRAL-TRIO lipid binding domain superfamily [IPR036865]", "CRAL/TRIO, N-terminal domain superfamily [IPR036273]", "CRIB domain superfamily [IPR036936]", "CSTF1, dimerization domain superfamily [IPR038184]", "Cadherin-like superfamily [IPR015919]", "Calcyclin-binding protein, N-terminal [IPR037201]", "Calpain large subunit, domain III superfamily [IPR036213]", "Calreticulin/calnexin, P domain superfamily [IPR009033]", "Carbamoyl-phosphate synthase small subunit, N-terminal domain superfamily [IPR036480]", "Carbamoyl-phosphate synthetase, large subunit oligomerisation domain superfamily [IPR036897]", "Carbohydrate-binding-like fold [IPR013784]", "Carbon-nitrogen hydrolase superfamily [IPR036526]", "Carboxypeptidase-like, regulatory domain superfamily [IPR008969]", "Carnitine o-acyltransferase, N-terminal [IPR042572]", "Casein kinase II subunit beta-like [IPR035991]", "Casein kinase II, regulatory subunit, N-terminal [IPR016149]", "Caspase-like domain superfamily [IPR029030]", "Catenin binding domain superfamily [IPR027397]", "Cathepsin C, exclusion domain superfamily [IPR036496]", "Cdc37, Hsp90-binding domain superfamily [IPR038189]", "Cell division control protein 73, C-terminal domain superfamily [IPR038103]", "Chaperone J-domain superfamily [IPR036869]", "Chitinase insertion domain superfamily [IPR029070]", "Chloramphenicol acetyltransferase-like domain superfamily [IPR023213]", "Chloride channel, core [IPR014743]", "Choline/Carnitine o-acyltransferase, domain 2 [IPR042231]", "Chromo-like domain superfamily [IPR016197]", "Citrate synthase superfamily [IPR036969]", "Citrate synthase-like, large alpha subdomain [IPR016142]", "Citrate synthase-like, small alpha subdomain [IPR016143]", "Class I and II aminoacyl-tRNA synthetase, tRNA-binding arm [IPR010978]", "Class I glutamine amidotransferase-like [IPR029062]", "Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL) [IPR045864]", "Class II aldolase/adducin N-terminal domain superfamily [IPR036409]", "Clathrin adaptor, appendage, Ig-like subdomain superfamily [IPR013041]", "Clathrin adaptor, beta-adaptin, appendage, Ig-like subdomain [IPR013037]", "Clathrin heavy chain, N-terminal [IPR016025]", "ClpP/crotonase-like domain superfamily [IPR029045]", "Coatomer, gamma subunit, appendage domain superfamily [IPR037067]", "Coatomer/calthrin adaptor appendage, C-terminal subdomain [IPR009028]", "Cobalamin (vitamin B12)-dependent enzyme, catalytic [IPR016176]", "Cobalamin adenosyltransferase-like superfamily [IPR036451]", "Cobalamin-binding domain superfamily [IPR036724]", "Concanavalin A-like lectin/glucanase domain superfamily [IPR013320]", "Costars domain superfamily [IPR038095]", "Creatinase/Aminopeptidase P/Spt16, N-terminal [IPR029149]", "Creatinase/aminopeptidase-like [IPR036005]", "Cullin homology domain superfamily [IPR036317]", "Cullin repeat-like-containing domain superfamily [IPR016159]", "Cupredoxin [IPR008972]", "Cyclase-associated protein CAP/septum formation inhibitor MinC, C-terminal [IPR016098]", "Cyclic nucleotide-binding-like [IPR018490]", "Cyclic phosphodiesterase [IPR009097]", "Cyclin-like superfamily [IPR036915]", "Cyclophilin-like domain superfamily [IPR029000]", "Cytidine deaminase-like [IPR016193]", "Cytochrome C oxidase subunit II, transmembrane domain superfamily [IPR036257]", "Cytochrome P450 superfamily [IPR036396]", "Cytochrome b-c1 complex subunit 7 superfamily [IPR036544]", "Cytochrome b-c1 complex subunit 8 superfamily [IPR036642]", "Cytochrome b-c1 complex subunit 9 superfamily [IPR036656]", "Cytochrome b5-like heme/steroid binding domain superfamily [IPR036400]", "Cytochrome bc1 complex subunit Rieske, transmembrane domain superfamily [IPR037008]", "Cytochrome c oxidase subunit IV superfamily [IPR036639]", "Cytochrome c oxidase, subunit VIIa superfamily [IPR036539]", "Cytochrome c oxidase, subunit Va/VI superfamily [IPR036545]", "Cytochrome c oxidase, subunit Vb superfamily [IPR036972]", "Cytochrome c-like domain superfamily [IPR036909]", "Cytochrome c1, transmembrane anchor, C-terminal [IPR021157]", "Cytochrome cd1-nitrite reductase-like, haem d1 domain superfamily [IPR011048]", "DCN1-like, PONY binding domain [IPR042460]", "DHS-like NAD/FAD-binding domain superfamily [IPR029035]", "DNA breaking-rejoining enzyme, catalytic core [IPR011010]", "DNA fragmentation factor 45kDa, C-terminal [IPR027296]", "DNA glycosylase [IPR011257]", "DNA ligase, ATP-dependent, N-terminal domain superfamily [IPR036599]", "DNA mismatch repair protein MutS, N-terminal [IPR016151]", "DNA mismatch repair protein MutS, core domain superfamily [IPR036187]", "DNA polymerase III, clamp loader complex, gamma/delta/delta subunit, C-terminal [IPR008921]", "DNA polymerase alpha, subunit B, N-terminal domain superfamily [IPR043034]", "DNA polymerase alpha, zinc finger domain superfamily [IPR038256]", "DNA polymerase family B, thumb domain [IPR042087]", "DNA polymerase, palm domain superfamily [IPR023211]", "DNA repair protein XRCC4-like, C-terminal [IPR014751]", "DNA topoisomerase I, DNA binding, N-terminal domain 1 [IPR013034]", "DNA topoisomerase I, DNA binding, N-terminal domain 2 [IPR013030]", "DNA topoisomerase I, DNA binding, eukaryotic-type, N-terminal domain superfamily [IPR036202]", "DNA topoisomerase I, catalytic core, alpha-helical subdomain, eukaryotic-type [IPR014711]", "DNA topoisomerase I, catalytic core, alpha/beta subdomain [IPR014727]", "DNA topoisomerase, type IIA, alpha-helical domain superfamily [IPR013757]", "DNA topoisomerase, type IIA, domain A, alpha-beta [IPR013758]", "DNA topoisomerase, type IIA, subunit B, C-terminal [IPR013759]", "DNA topoisomerase, type IIA-like domain superfamily [IPR013760]", "DNA-binding domain superfamily [IPR016177]", "DNA-directed RNA polymerase, N-terminal domain superfamily [IPR037159]", "DNA-directed RNA polymerase, insert domain superfamily [IPR036643]", "DNA-directed RNA polymerase, subunit 2, hybrid-binding domain superfamily [IPR037033]", "DNA/RNA non-specific endonuclease superfamily [IPR044929]", "DNA/RNA polymerase superfamily [IPR043502]", "DNA/RNA-binding protein KIN17, WH-like domain superfamily [IPR038254]", "DUSP-like superfamily [IPR035927]", "Dbl homology (DH) domain superfamily [IPR035899]", "Death-like domain superfamily [IPR011029]", "Dedicator of cytokinesis, C-terminal, lobe A [IPR043161]", "Dedicator of cytokinesis, C-terminal, lobe C [IPR043162]", "Deltex, C-terminal domain superfamily [IPR039399]", "Deoxyhypusine synthase superfamily [IPR036982]", "Diaphanous, GTPase-binding domain superfamily [IPR044933]", "Dicer dimerisation domain superfamily [IPR038248]", "Dihydrofolate reductase-like domain superfamily [IPR024072]", "Dihydropteroate synthase-like [IPR011005]", "Dimeric alpha-beta barrel [IPR011008]", "Diphthamide synthesis DPH1/DPH2, domain 1 [IPR042263]", "Diphthamide synthesis DPH1/DPH2, domain 3 [IPR042265]", "Dynein heavy chain AAA lid domain superfamily [IPR042219]", "Dynein heavy chain, AAA1 domain, small subdomain [IPR043157]", "Dynein heavy chain, C-terminal domain, barrel region [IPR043160]", "Dynein heavy chain, domain 2, N-terminal [IPR042222]", "Dynein heavy chain, linker, subdomain 3 [IPR042228]", "Dynein light chain superfamily [IPR037177]", "E2 domain superfamily [IPR036176]", "E3 ubiquitin-protein ligase ELL-like [IPR042065]", "E3-binding domain superfamily [IPR036625]", "EB1, C-terminal domain superfamily [IPR036133]", "EF-G domain III/V-like [IPR035647]", "EF-hand domain pair [IPR011992]", "ENTH/VHS [IPR008942]", "ERO1-like superfamily [IPR037192]", "ERV/ALR sulfhydryl oxidase domain superfamily [IPR036774]", "ESCRT assembly domain [IPR037202]", "EXOC6/PINT-1/Sec15/Tip20, C-terminal, domain 2 [IPR042044]", "EYA domain superfamily [IPR038102]", "Elongation factor EF1B gamma, C-terminal domain superfamily [IPR036433]", "Elongation factor Ts, dimerisation domain superfamily [IPR036402]", "Endonuclease/exonuclease/phosphatase superfamily [IPR036691]", "Endoplasmic reticulum resident protein 29, C-terminal domain superfamily [IPR036356]", "Enhancer of mRNA-decapping protein 4, conserved C-terminal domain [IPR044938]", "Enhancer of rudimentary superfamily [IPR035912]", "Enolase-like, C-terminal domain superfamily [IPR036849]", "Enolase-like, N-terminal [IPR029017]", "Enoyl-CoA hydratase, C-terminal [IPR014748]", "Eukaryotic translation initiation factor 3-like domain superfamily [IPR023194]", "Exocyst complex component EXOC3/Sec6, C-terminal domain [IPR042532]", "Exocyst complex component EXOC6/Sec15, C-terminal, domain 1 [IPR042045]", "Exocyst component Exo84, C-terminal, subdomain 1 [IPR042561]", "Exocyst component Exo84, C-terminal, subdomain 2 [IPR042560]", "Exoribonuclease, PH domain 2 superfamily [IPR036345]", "F-actin capping protein, alpha subunit, domain 1 [IPR042489]", "F-actin-capping protein subunit alpha/beta [IPR037282]", "F-actin-capping protein subunit alpha/beta, domain 2 [IPR042276]", "F-actin-capping protein subunit beta, N-terminal domain [IPR043175]", "F-box-like domain superfamily [IPR036047]", "F1F0 ATP synthase OSCP/delta subunit, N-terminal domain superfamily [IPR026015]", "FAD-binding, type PCMH, subdomain 1 [IPR016167]", "FAD-binding, type PCMH, subdomain 2 [IPR016169]", "FAD-binding, type PCMH-like superfamily [IPR036318]", "FAD-linked oxidase-like, C-terminal [IPR016164]", "FAD/NAD(P)-binding domain superfamily [IPR036188]", "FAD/NAD-linked reductase, dimerisation domain superfamily [IPR016156]", "FERM superfamily, second domain [IPR035963]", "FERM/acyl-CoA-binding protein superfamily [IPR014352]", "FF domain superfamily [IPR036517]", "FIP-RBD, C-terminal domain superfamily [IPR037245]", "FKBP12-rapamycin binding domain superfamily [IPR036738]", "FTO, C-terminal domain superfamily [IPR038413]", "Fe-S cluster assembly domain superfamily [IPR034904]", "Ferredoxin-NADP reductase (FNR), nucleotide-binding domain [IPR039261]", "Ferritin-like superfamily [IPR009078]", "Fibronectin type II domain superfamily [IPR036943]", "Fibronectin type III superfamily [IPR036116]", "Flavin prenyltransferase-like [IPR036551]", "Flavoprotein-like superfamily [IPR029039]", "Focal adhesion kinase, targeting (FAT) domain superfamily [IPR036137]", "Formin, FH2 domain superfamily [IPR042201]", "Formyl transferase, N-terminal domain superfamily [IPR036477]", "Formyl transferase-like, C-terminal domain superfamily [IPR011034]", "Fumarase/histidase, N-terminal [IPR024083]", "Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain superfamily [IPR037099]", "Fumarate reductase/succinate dehydrogenase, transmembrane subunit [IPR034804]", "Fumarylacetoacetase, N-terminal domain superfamily [IPR036462]", "Fumarylacetoacetase-like, C-terminal domain superfamily [IPR036663]", "G protein alpha subunit, helical insertion [IPR011025]", "G-protein gamma-like domain superfamily [IPR036284]", "GAD-like domain superfamily [IPR004115]", "GAR domain superfamily [IPR036534]", "GAT domain superfamily [IPR038425]", "GBBH-like, N-terminal domain superfamily [IPR038492]", "GHMP kinase, C-terminal domain superfamily [IPR036554]", "GINS complex, subunit Psf3 superfamily [IPR038437]", "GINS, helical bundle-like domain superfamily [IPR036224]", "GLE1-like superfamily [IPR038506]", "GM2-AP, lipid-recognition domain superfamily [IPR036846]", "GOLD domain superfamily [IPR036598]", "GSKIP domain superfamily [IPR023231]", "GTF2I-like repeat superfamily [IPR036647]", "GTP-binding protein TrmE/Aminomethyltransferase GcvT, domain 1 [IPR027266]", "GTP-binding protein, orthogonal bundle domain superfamily [IPR023179]", "GTP1/OBG domain superfamily [IPR036726]", "GYF-like domain superfamily [IPR035445]", "Galactose mutarotase-like domain superfamily [IPR011013]", "Galactose oxidase/kelch, beta-propeller [IPR011043]", "Galactose-binding-like domain superfamily [IPR008979]", "Gamma-glutamyl cyclotransferase-like superfamily [IPR036568]", "Gamma-glutamyltranspeptidase, large subunit, C-terminal domain [IPR043138]", "Gamma-glutamyltranspeptidase, small subunit [IPR043137]", "Gamma-tubulin complex component, C-terminal domain superfamily [IPR042241]", "Gelsolin-like domain superfamily [IPR036180]", "Globular protein, non-globular alpha/beta subunit [IPR011070]", "Glutamine synthetase/guanido kinase, catalytic domain [IPR014746]", "Glutaminyl-tRNA synthetase, class Ib, non-specific RNA-binding domain, N-terminal, subdomain 1 [IPR042558]", "Glutaminyl-tRNA synthetase, class Ib, non-specific RNA-binding domain, N-terminal, subdomain 2 [IPR042559]", "Glutathione S-transferase, C-terminal domain superfamily [IPR036282]", "Glutathione synthase, C-terminal, eukaryotic [IPR014709]", "Glutathione synthase, N-terminal, eukaryotic [IPR014049]", "Glutathione synthase, alpha-helical [IPR014042]", "Glutathione synthase, substrate-binding domain superfamily [IPR037013]", "Glycolipid transfer protein superfamily [IPR036497]", "Glycoside hydrolase 38, N-terminal domain superfamily [IPR027291]", "Glycoside hydrolase families 57/38, central domain superfamily [IPR028995]", "Glycoside hydrolase family 38, central domain superfamily [IPR037094]", "Glycoside hydrolase superfamily [IPR017853]", "Glycoside hydrolase-type carbohydrate-binding [IPR014718]", "Glycoside hydrolase/deacetylase, beta/alpha-barrel [IPR011330]", "Glycosyl hydrolase family 63, N-terminal domain superfamily [IPR038518]", "Glycosyl hydrolase, all-beta [IPR013780]", "Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase [IPR029068]", "GroEL-like apical domain superfamily [IPR027409]", "GroEL-like equatorial domain superfamily [IPR027413]", "GroES chaperonin superfamily [IPR037124]", "GroES-like superfamily [IPR011032]", "Growth arrest and DNA damage-inducible proteins-interacting protein 1 domain superfamily [IPR043035]", "Growth factor receptor cysteine-rich domain superfamily [IPR009030]", "GrpE nucleotide exchange factor, coiled-coil [IPR013805]", "GrpE nucleotide exchange factor, head [IPR009012]", "Guanylate-binding protein, C-terminal domain superfamily [IPR036543]", "H/ACA RNP complex subunit Gar1/Naf1, Cbf5-binding domain [IPR038664]", "HAD superfamily [IPR023214]", "HAD-like superfamily [IPR036412]", "HBS1-like protein, N-terminal domain superfamily [IPR037189]", "HECT, E3 ligase catalytic domain [IPR035983]", "HIT-like superfamily [IPR036265]", "HIV integrase-binding domain superfamily [IPR036218]", "HR1 repeat superfamily [IPR036274]", "HRDC domain superfamily [IPR044876]", "HRDC-like superfamily [IPR010997]", "HSP20-like chaperone [IPR008978]", "HSP40/DnaJ peptide-binding [IPR008971]", "HSP90, C-terminal domain [IPR037196]", "Haem oxygenase-like, multi-helical [IPR016084]", "Heat shock protein 70kD, C-terminal domain superfamily [IPR029048]", "Heat shock protein 70kD, peptide-binding domain superfamily [IPR029047]", "Heat shock protein DnaJ, cysteine-rich domain superfamily [IPR036410]", "Heavy metal-associated domain superfamily [IPR036163]", "Helix hairpin bin domain superfamily [IPR029012]", "Helix-hairpin-helix, base-excision DNA repair, C-terminal [IPR023170]", "Hemimethylated DNA-binding domain superfamily [IPR036623]", "High mobility group box domain superfamily [IPR036910]", "His-Me finger superfamily [IPR044925]", "Histidine kinase/HSP90-like ATPase superfamily [IPR036890]", "Histidine phosphatase superfamily [IPR029033]", "Histone acetyl transferase 1, N-terminal domain superfamily [IPR037113]", "Histone acetyltransferase HAT1, C-terminal [IPR013523]", "Histone deacetylase domain superfamily [IPR037138]", "Histone-fold [IPR009072]", "Homeobox-like domain superfamily [IPR009057]", "Homocysteine-binding domain superfamily [IPR036589]", "HotDog domain superfamily [IPR029069]", "Hydroxymethylglutaryl-CoA reductase, N-terminal [IPR023282]", "Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain superfamily [IPR009023]", "Hydroxymethylglutaryl-CoA reductase, class I/II, catalytic domain superfamily [IPR023074]", "Hydroxymethylglutaryl-CoA reductase, class I/II, substrate-binding domain superfamily [IPR009029]", "I/LWEQ domain superfamily [IPR035964]", "IFT81, N-terminal domain superfamily [IPR043016]", "ISWI, HAND domain superfamily [IPR036306]", "Immunoglobulin E-set [IPR014756]", "Immunoglobulin-like domain superfamily [IPR036179]", "Immunoglobulin-like fold [IPR013783]", "Importin-alpha, importin-beta-binding domain superfamily [IPR036975]", "Initiation factor 2B-like, C-terminal [IPR042529]", "Inorganic polyphosphate/ATP-NAD kinase, N-terminal [IPR017438]", "Inorganic pyrophosphatase superfamily [IPR036649]", "Inosine triphosphate pyrophosphatase-like [IPR029001]", "Integrin beta tail domain superfamily [IPR036349]", "Integrin domain superfamily [IPR032695]", "Interferon regulatory factor 2-binding protein 1/2, C3HC4-type RING finger superfamily [IPR044882]", "Invasin/intimin cell-adhesion fragments [IPR008964]", "Isochorismatase-like superfamily [IPR036380]", "Isopenicillin N synthase-like superfamily [IPR027443]", "Isoprenoid synthase domain superfamily [IPR008949]", "K Homology domain, type 1 superfamily [IPR036612]", "K homology domain superfamily, prokaryotic type [IPR009019]", "K homology domain-like, alpha/beta [IPR015946]", "KA1 domain/Ssp2, C-terminal [IPR028375]", "Kelch-type beta propeller [IPR015915]", "Kinesin motor domain superfamily [IPR036961]", "Kinesin-like protein Kif23, Arf6-interacting domain superfamily [IPR038105]", "Kringle-like fold [IPR013806]", "Ku, C-terminal domain superfamily [IPR036494]", "Ku70, bridge and pillars domain superfamily [IPR027388]", "L-Aspartase-like [IPR008948]", "L21-like superfamily [IPR036164]", "L27 domain superfamily [IPR036892]", "L28p-like [IPR034704]", "LAP1C-like, C-terminal domain superfamily [IPR038599]", "LDL receptor-like superfamily [IPR036055]", "LEM/LEM-like domain superfamily [IPR011015]", "LIS1, N-terminal [IPR037190]", "LSM domain superfamily [IPR010920]", "Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal [IPR015955]", "Lambda repressor-like, DNA-binding domain superfamily [IPR010982]", "Lamin tail domain superfamily [IPR036415]", "LepA, C-terminal domain superfamily [IPR038363]", "Leucine-rich repeat domain superfamily [IPR032675]", "LexA/Signal peptidase-like superfamily [IPR036286]", "Longin-like domain superfamily [IPR011012]", "MAGE homology domain, winged helix WH1 motif [IPR041898]", "MAGE homology domain, winged helix WH2 motif [IPR041899]", "MAN1, winged-helix domain [IPR041885]", "MFS transporter superfamily [IPR036259]", "MHC class I-like antigen recognition-like superfamily [IPR037055]", "MHC classes I/II-like antigen recognition protein [IPR011162]", "MIT domain superfamily [IPR036181]", "MRG, C-terminal domain superfamily [IPR038217]", "MRP-L47 superfamily, mitochondrial [IPR038340]", "MTH938-like superfamily [IPR036748]", "Macro domain-like [IPR043472]", "Malic enzyme, N-terminal domain superfamily [IPR037062]", "Malonyl-CoA ACP transacylase, ACP-binding [IPR016036]", "Manganese/iron superoxide dismutase, C-terminal domain superfamily [IPR036314]", "Manganese/iron superoxide dismutase, N-terminal domain superfamily [IPR036324]", "Mannose-6-phosphate receptor binding domain superfamily [IPR009011]", "Membrane associated eicosanoid/glutathione metabolism-like domain superfamily [IPR023352]", "Metal-dependent hydrolase [IPR032466]", "Metal-dependent hydrolase, composite domain superfamily [IPR011059]", "Metallo-dependent phosphatase-like [IPR029052]", "Metalloenzyme, LuxS/M16 peptidase-like [IPR011249]", "Metallopeptidase, catalytic domain superfamily [IPR024079]", "Methionine synthase domain [IPR036594]", "Methionyl-tRNA synthetase, Zn-domain [IPR029038]", "Methylglyoxal synthase-like domain superfamily [IPR036914]", "Methylpurine-DNA glycosylase superfamily [IPR036995]", "Methylthiotransferase, N-terminal domain superfamily [IPR038135]", "Mib/herc2 domain superfamily [IPR037252]", "MitoNEET, CDGSH iron-sulfur domain [IPR042216]", "Mitochondrial carrier domain superfamily [IPR023395]", "Mitochondrial cytochrome c oxidase subunit VIc/VIIs superfamily [IPR037169]", "Mitochondrial glycoprotein superfamily [IPR036561]", "Mitochondrial outer membrane translocase complex, Tom20 domain superfamily [IPR023392]", "MoaB/Mog-like domain superfamily [IPR036425]", "MoeA, C-terminal, domain IV superfamily [IPR036688]", "MoeA, N-terminal and linker domain superfamily [IPR036135]", "Moesin tail domain superfamily [IPR008954]", "Mre11, capping domain [IPR038487]", "Mss4-like superfamily [IPR011057]", "Mss4/translationally controlled tumour-associated TCTP [IPR011323]", "Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal domain superfamily [IPR042179]", "MutS, connector domain superfamily [IPR036678]", "Myosin S1 fragment, N-terminal [IPR008989]", "NAC A/B domain superfamily [IPR038187]", "NAD kinase/diacylglycerol kinase-like domain superfamily [IPR016064]", "NAD(P)-binding domain superfamily [IPR036291]", "NADH-quinone oxidoreductase subunit E, N-terminal [IPR041921]", "NADH-ubiquinone oxidoreductase 51kDa subunit, FMN-binding domain superfamily [IPR037225]", "NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain superfamily [IPR037207]", "NADH:ubiquinone oxidoreductase, 30kDa subunit superfamily [IPR037232]", "NADP-dependent oxidoreductase domain superfamily [IPR036812]", "NADPH-cytochrome p450 reductase, FAD-binding, alpha-helical domain superfamily [IPR023173]", "NAP-like superfamily [IPR037231]", "NET domain superfamily [IPR038336]", "NO signalling/Golgi transport ligand-binding domain superfamily [IPR024096]", "NOB1 zinc finger-like superfamily [IPR036283]", "NTF2-like domain superfamily [IPR032710]", "NUDIX hydrolase-like domain superfamily [IPR015797]", "NVL2, N-terminal domain superfamily [IPR038100]", "NagB/RpiA transferase-like [IPR037171]", "Ndc80 domain superfamily [IPR038273]", "Neurolysin/Thimet oligopeptidase, N-terminal [IPR024080]", "Neurolysin/Thimet oligopeptidase, domain 2 [IPR024077]", "Nibrin, second BRCT domain superfamily [IPR043014]", "Nicotinate phosphoribosyltransferase-like, C-terminal [IPR036068]", "Nitrogen regulatory PII-like, alpha/beta [IPR011322]", "Nitrogen regulatory protein PII/ATP phosphoribosyltransferase, C-terminal [IPR015867]", "Nitrous oxide reductase, N-terminal [IPR011045]", "Nop domain superfamily [IPR036070]", "Nop, C-terminal domain [IPR042239]", "Notch-like domain superfamily [IPR035993]", "Nucleic acid-binding, OB-fold [IPR012340]", "Nucleophile aminohydrolases, N-terminal [IPR029055]", "Nucleoplasmin core domain superfamily [IPR036824]", "Nucleoporin, Nup155-like, C-terminal, subdomain 1 [IPR042533]", "Nucleoporin, Nup155-like, C-terminal, subdomain 2 [IPR042537]", "Nucleoporin, Nup155-like, C-terminal, subdomain 3 [IPR042538]", "Nucleoside diphosphate kinase-like domain superfamily [IPR036850]", "Nucleoside phosphorylase superfamily [IPR035994]", "Nucleotide-binding alpha-beta plait domain superfamily [IPR012677]", "Nucleotide-diphospho-sugar transferases [IPR029044]", "Nucleotidyltransferase superfamily [IPR043519]", "Nucleotidyltransferase, class I-like, C-terminal [IPR011068]", "Nuf2, N-terminal domain superfamily [IPR038275]", "NusG, N-terminal domain superfamily [IPR036735]", "Oxygen-dependent coproporphyrinogen III oxidase superfamily [IPR036406]", "Oxysterol-binding protein superfamily [IPR037239]", "P-loop containing nucleoside triphosphate hydrolase [IPR027417]", "P-type ATPase, A domain superfamily [IPR008250]", "P-type ATPase, cytoplasmic domain N [IPR023299]", "P-type ATPase, transmembrane domain superfamily [IPR023298]", "P-type trefoil domain superfamily [IPR044913]", "PABC (PABP) domain [IPR036053]", "PADR1 domain superfamily [IPR038650]", "PAZ domain superfamily [IPR036085]", "PBDC1-like domain superfamily [IPR023139]", "PD-(D/E)XK endonuclease-like domain superfamily [IPR011604]", "PDCD5-like superfamily [IPR036883]", "PDZ superfamily [IPR036034]", "PEBP-like superfamily [IPR036610]", "PFU domain superfamily [IPR038122]", "PH-like domain superfamily [IPR011993]", "PHR domain superfamily [IPR038648]", "PIN-like domain superfamily [IPR029060]", "PITH domain superfamily [IPR037047]", "PKD domain superfamily [IPR035986]", "PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily [IPR017946]", "PNPase/RNase PH domain superfamily [IPR027408]", "POLO box domain superfamily [IPR036947]", "PPM-type phosphatase domain superfamily [IPR036457]", "PRC-barrel-like superfamily [IPR011033]", "PRP4-like superfamily [IPR036285]", "PTPA superfamily [IPR037218]", "PUA domain superfamily [IPR036974]", "PUA-like superfamily [IPR015947]", "PWI domain superfamily [IPR036483]", "PX domain superfamily [IPR036871]", "Paired amphipathic helix superfamily [IPR036600]", "Pancreatic trypsin inhibitor Kunitz domain superfamily [IPR036880]", "PapD-like superfamily [IPR008962]", "Papain-like cysteine peptidase superfamily [IPR038765]", "Pectin lyase fold [IPR012334]", "Pectin lyase fold/virulence factor [IPR011050]", "Pelota/DOM34, N-terminal domain [IPR038069]", "Peptidase C12, ubiquitin carboxyl-terminal hydrolase superfamily [IPR036959]", "Peptidase C65, otubain, subdomain 2 [IPR042467]", "Peptidase C65, otubain, subdomain 1 [IPR042468]", "Peptidase M1, LTA-4 hydrolase/aminopeptidase, C-terminal domain superfamily [IPR038502]", "Peptidase M13, domain 2 [IPR042089]", "Peptidase M4/M1, CTD superfamily [IPR027268]", "Peptidase M41-like [IPR037219]", "Peptidase M60, enhancin-like domain 3 [IPR042279]", "Peptidase S1, PA clan [IPR009003]", "Peptidase S59, nucleoporin superfamily [IPR036903]", "Peptidase S8/S53 domain superfamily [IPR036852]", "Peptidyl-tRNA hydrolase II domain superfamily [IPR023476]", "Pex19, C-terminal domain superfamily [IPR038322]", "Phenylalanyl-tRNA synthetase-like, B3/B4 [IPR020825]", "Phosphatidic acid phosphatase type 2/haloperoxidase superfamily [IPR036938]", "Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily [IPR036940]", "Phosphatidylinositol-4-phosphate 5-kinase, N-terminal [IPR027484]", "Phosphofructokinase superfamily [IPR035966]", "Phosphoglucose isomerase, C-terminal [IPR023096]", "Phosphoglycerate kinase superfamily [IPR036043]", "Phosphoglycerate kinase, N-terminal [IPR015824]", "Phosphoglycolate phosphatase-like, domain 2 [IPR023198]", "Phosphoinositide 3-kinase, accessory (PIK) domain superfamily [IPR042236]", "Phospholipase B-like, domain 1 [IPR043040]", "Phospholipase B-like, domain 2 [IPR043041]", "Phospholipase B-like, domain 3 [IPR043042]", "Phosphoribosylformylglycinamidine synthase subunit PurS-like superfamily [IPR036604]", "Phosphoribosylglycinamide synthetase, C-domain superfamily [IPR037123]", "Phosphoribosyltransferase-like [IPR029057]", "Phosphotransferase/anion transporter [IPR016152]", "Phosphotyrosine protein phosphatase I superfamily [IPR036196]", "Phosphotyrosyl phosphatase activator, C-terminal lid domain [IPR043170]", "Plakin repeat superfamily [IPR035915]", "Poly(ADP-ribose) polymerase, regulatory domain superfamily [IPR036616]", "Polyketide synthase, dehydratase domain superfamily [IPR042104]", "Polymerase/histidinol phosphatase-like [IPR016195]", "Polyribonucleotide nucleotidyltransferase, RNA-binding domain superfamily [IPR036456]", "Porin domain superfamily [IPR023614]", "Porphobilinogen deaminase, C-terminal domain superfamily [IPR036803]", "Pre-ATP-grasp domain superfamily [IPR016185]", "Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding domain superfamily [IPR042516]", "Pre-mRNA-splicing factor Isy1 superfamily [IPR037200]", "Prefoldin [IPR009053]", "Profilin superfamily [IPR036140]", "Prolyl-tRNA synthetase, class II [IPR017449]", "Proteasomal ubiquitin receptor Rpn13/ADRM1, Pru domain superfamily [IPR038633]", "Proteasome activator PA28, C-terminal domain superfamily [IPR036997]", "Proteasome activator PA28, N-terminal domain superfamily [IPR036996]", "Proteasome activator superfamily [IPR036252]", "Proteasome assembly chaperone 2 superfamily [IPR038389]", "Protein arginine methyltransferase NDUFAF7 superfamily [IPR038375]", "Protein kinase-like domain superfamily [IPR011009]", "Protein-tyrosine phosphatase-like [IPR029021]", "Prp8 RNase domain IV, fingers region [IPR043173]", "Prp8 RNase domain IV, palm region [IPR043172]", "Pseudouridine synthase I, TruA, C-terminal [IPR020095]", "Pseudouridine synthase TruA/RsuA/RluB/E/F, N-terminal [IPR020094]", "Pseudouridine synthase, TruD, catalytic domain [IPR042214]", "Pseudouridine synthase, catalytic domain superfamily [IPR020103]", "Pterin 4 alpha carbinolamine dehydratase superfamily [IPR036428]", "PurM-like, C-terminal domain superfamily [IPR036676]", "PurM-like, N-terminal domain superfamily [IPR036921]", "Putative DNA-binding domain superfamily [IPR009061]", "Pyridoxal phosphate-dependent transferase [IPR015424]", "Pyridoxal phosphate-dependent transferase, major domain [IPR015421]", "Pyridoxal phosphate-dependent transferase, small domain [IPR015422]", "Pyruvate kinase, C-terminal domain superfamily [IPR036918]", "Pyruvate kinase, insert domain superfamily [IPR015806]", "Pyruvate kinase-like domain superfamily [IPR040442]", "Pyruvate kinase-like, insert domain superfamily [IPR011037]", "Pyruvate/Phosphoenolpyruvate kinase-like domain superfamily [IPR015813]", "Queuine tRNA-ribosyltransferase-like [IPR036511]", "Quinoprotein alcohol dehydrogenase-like superfamily [IPR011047]", "Quinoprotein amine dehydrogenase, beta chain-like [IPR011044]", "R3H domain superfamily [IPR036867]", "RAP domain superfamily [IPR036744]", "RBP-J/Cbf11, DNA binding domain superfamily [IPR037095]", "RGS domain superfamily [IPR036305]", "RGS, subdomain 2 [IPR044926]", "RNA 3'-terminal phosphate cyclase domain superfamily [IPR037136]", "RNA 3'-terminal phosphate cyclase, insert domain superfamily [IPR036553]", "RNA 3'-terminal phosphate cyclase/enolpyruvate transferase, alpha/beta [IPR013792]", "RNA polymerase Rpb1, clamp domain superfamily [IPR044893]", "RNA polymerase Rpb1, domain 3 superfamily [IPR042102]", "RNA polymerase Rpb1, domain 7 superfamily [IPR038593]", "RNA polymerase Rpb1, funnel domain superfamily [IPR038120]", "RNA polymerase Rpb2, OB-fold [IPR014724]", "RNA polymerase Rpb2, domain 2 superfamily [IPR037034]", "RNA polymerase Rpb5, N-terminal domain superfamily [IPR036710]", "RNA polymerase Rpb7-like, N-terminal domain superfamily [IPR036898]", "RNA polymerase subunit RPB10 [IPR023580]", "RNA polymerase, RBP11-like subunit [IPR036603]", "RNA-binding S4 domain superfamily [IPR036986]", "RNA-binding domain superfamily [IPR035979]", "RPB5-like RNA polymerase subunit superfamily [IPR035913]", "RPN13, DEUBAD domain superfamily [IPR038108]", "RRF superfamily [IPR036191]", "RUN domain superfamily [IPR037213]", "Rab geranylgeranyltransferase, alpha subunit, insert-domain superfamily [IPR036254]", "Rab-GTPase-TBC domain superfamily [IPR035969]", "Radical SAM, alpha/beta horseshoe [IPR023404]", "Ran-GTPase activating protein 1, C-terminal domain superfamily [IPR036720]", "Ras guanine nucleotide exchange factor domain superfamily [IPR023578]", "Ras guanine-nucleotide exchange factor, catalytic domain superfamily [IPR036964]", "Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II [IPR009091]", "Regulatory factor, effector binding domain superfamily [IPR011256]", "Rho GDP-dissociation inhibitor domain superfamily [IPR024792]", "Rho GTPase activation protein [IPR008936]", "Rhodanese-like domain superfamily [IPR036873]", "Rhomboid-like superfamily [IPR035952]", "Riboflavin synthase-like beta-barrel [IPR017938]", "Ribokinase-like [IPR029056]", "Ribonuclease H superfamily [IPR036397]", "Ribonuclease H-like superfamily [IPR012337]", "Ribonuclease H1, N-terminal domain superfamily [IPR037056]", "Ribonuclease HII, helix-loop-helix cap domain superfamily [IPR023160]", "Ribonuclease III, endonuclease domain superfamily [IPR036389]", "Ribonuclease P/MRP subunit Rpp29 superfamily [IPR036980]", "Ribonuclease T2-like superfamily [IPR036430]", "Ribonuclease Z/Hydroxyacylglutathione hydrolase-like [IPR036866]", "Ribonucleotide reductase R1 subunit, N-terminal [IPR008926]", "Ribonucleotide reductase-like [IPR012348]", "Ribosomal L15/L27a, N-terminal [IPR027386]", "Ribosomal L18e/L15P superfamily [IPR036227]", "Ribosomal RNA-processing protein 8, N-terminal domain [IPR042036]", "Ribosomal protein L1, 3-layer alpha/beta-sandwich [IPR016095]", "Ribosomal protein L1-like [IPR023674]", "Ribosomal protein L10-like domain superfamily [IPR043141]", "Ribosomal protein L10e/L16 superfamily [IPR036920]", "Ribosomal protein L11, C-terminal domain superfamily [IPR036769]", "Ribosomal protein L11/L12, N-terminal domain superfamily [IPR036796]", "Ribosomal protein L13 superfamily [IPR036899]", "Ribosomal protein L14 superfamily [IPR036853]", "Ribosomal protein L15e core domain superfamily [IPR024794]", "Ribosomal protein L17 superfamily [IPR036373]", "Ribosomal protein L19 superfamily [IPR038657]", "Ribosomal protein L19/L19e superfamily [IPR035970]", "Ribosomal protein L19/L19e, domain 1 [IPR015972]", "Ribosomal protein L2, domain 2 [IPR014722]", "Ribosomal protein L2, domain 3 [IPR014726]", "Ribosomal protein L20, C-terminal [IPR035566]", "Ribosomal protein L21 superfamily [IPR036948]", "Ribosomal protein L22/L17 superfamily [IPR036394]", "Ribosomal protein L22e superfamily [IPR038526]", "Ribosomal protein L23/L15e core domain superfamily [IPR012678]", "Ribosomal protein L24e/L24 superfamily [IPR038630]", "Ribosomal protein L25/Gln-tRNA synthetase, N-terminal [IPR020056]", "Ribosomal protein L25/Gln-tRNA synthetase, anti-codon-binding domain superfamily [IPR011035]", "Ribosomal protein L27e superfamily [IPR038655]", "Ribosomal protein L28/L24 superfamily [IPR037147]", "Ribosomal protein L29/L35 superfamily [IPR036049]", "Ribosomal protein L3, domain 3, archaeal type superfamily [IPR044892]", "Ribosomal protein L30, ferredoxin-like fold domain superfamily [IPR036919]", "Ribosomal protein L31e domain superfamily [IPR023621]", "Ribosomal protein L32e superfamily [IPR036351]", "Ribosomal protein L35A superfamily [IPR038661]", "Ribosomal protein L36e domain superfamily [IPR038097]", "Ribosomal protein L37ae/L37e [IPR011331]", "Ribosomal protein L38e superfamily [IPR038464]", "Ribosomal protein L4 domain superfamily [IPR023574]", "Ribosomal protein L5 domain superfamily [IPR022803]", "Ribosomal protein L6, alpha-beta domain superfamily [IPR036789]", "Ribosomal protein L7/L12, C-terminal/adaptor protein ClpS-like [IPR014719]", "Ribosomal protein L7/L12, oligomerisation domain superfamily [IPR036235]", "Ribosomal protein L9, N-terminal domain superfamily [IPR036935]", "Ribosomal protein L9/RNase H1, N-terminal [IPR009027]", "Ribosomal protein P1/P2, N-terminal domain [IPR038716]", "Ribosomal protein S10 domain superfamily [IPR036838]", "Ribosomal protein S11 superfamily [IPR036967]", "Ribosomal protein S13-like, H2TH [IPR010979]", "Ribosomal protein S14/S29 [IPR043140]", "Ribosomal protein S16 domain superfamily [IPR023803]", "Ribosomal protein S17e-like superfamily [IPR036401]", "Ribosomal protein S18 superfamily [IPR036870]", "Ribosomal protein S19/S15, superfamily [IPR023575]", "Ribosomal protein S2, flavodoxin-like domain superfamily [IPR023591]", "Ribosomal protein S21e superfamily [IPR038579]", "Ribosomal protein S26e superfamily [IPR038551]", "Ribosomal protein S3, C-terminal domain superfamily [IPR036419]", "Ribosomal protein S4e, central domain superfamily [IPR038237]", "Ribosomal protein S5 domain 2-type fold [IPR020568]", "Ribosomal protein S5 domain 2-type fold, subgroup [IPR014721]", "Ribosomal protein S7 domain superfamily [IPR036823]", "Ribosomal protein S8 superfamily [IPR035987]", "Ribosomal protein S8e subdomain, eukaryotes [IPR042563]", "Ribosome maturation protein SBDS, N-terminal domain superfamily [IPR036786]", "Ribosome maturation protein Sdo1/SBDS, central domain superfamily [IPR037188]", "Ribosome-associated complex head domain superfamily [IPR042569]", "Ribulose-phosphate binding barrel [IPR011060]", "Ricin B-like lectins [IPR035992]", "RmlC-like cupin domain superfamily [IPR011051]", "RmlC-like jelly roll fold [IPR014710]", "Rof/RNase P-like [IPR023534]", "Rossmann-like alpha/beta/alpha sandwich fold [IPR014729]", "Rpb4/RPC9 superfamily [IPR038324]", "Rubisco LSMT, substrate-binding domain superfamily [IPR036464]", "Rudiment single hybrid motif [IPR011054]", "RutC-like superfamily [IPR035959]", "RuvA domain 2-like [IPR010994]", "RuvBL1/2, DNA/RNA binding domain [IPR042487]", "S-adenosyl-L-methionine-dependent methyltransferase [IPR029063]", "S-adenosylmethionine synthetase superfamily [IPR022636]", "S15/NS1, RNA-binding [IPR009068]", "SAP domain superfamily [IPR036361]", "SCP2 sterol-binding domain superfamily [IPR036527]", "SGNH hydrolase superfamily [IPR036514]", "SH2 domain superfamily [IPR036860]", "SH3-like domain superfamily [IPR036028]", "SKA1 microtubule binding domain [IPR042031]", "SKP1-like, dimerisation domain superfamily [IPR036296]", "SKP1/BTB/POZ domain superfamily [IPR011333]", "SLED domain superfamily [IPR038348]", "SMAD/FHA domain superfamily [IPR008984]", "SMCs flexible hinge superfamily [IPR036277]", "SNARE [IPR010989]", "SNF2-like, N-terminal domain superfamily [IPR038718]", "SNase-like, OB-fold superfamily [IPR035437]", "SOCS box-like domain superfamily [IPR036036]", "SOS response associated peptidase-like [IPR036590]", "SPOC-like, C-terminal domain superfamily [IPR016194]", "SRA-YDG superfamily [IPR036987]", "SRCR-like domain superfamily [IPR036772]", "SRP/SRP receptor, N-terminal [IPR036225]", "SRP68, N-terminal domain superfamily [IPR038253]", "SSRP1 domain superfamily [IPR038167]", "START-like domain superfamily [IPR023393]", "STAT transcription factor, DNA-binding, N-terminal [IPR012345]", "STAT transcription factor, N-terminal domain superfamily [IPR036535]", "STAT transcription factor, coiled coil [IPR015988]", "STAT1, C-terminal domain superfamily [IPR038295]", "SUI1 domain superfamily [IPR036877]", "SWAP/Surp superfamily [IPR035967]", "SWIB/MDM2 domain superfamily [IPR036885]", "Saposin-like [IPR011001]", "Scaffold protein Nfu/NifU, N-terminal domain superfamily [IPR036498]", "Scavenger mRNA decapping enzyme, N-terminal [IPR011145]", "Schlafen, AlbA_2 domain superfamily [IPR038461]", "ScpA-like, C-terminal [IPR023093]", "Sec1-like superfamily [IPR036045]", "Sec1-like, domain 1 [IPR043154]", "Sec1-like, domain 2 [IPR027482]", "Sec1-like, domain 3a [IPR043127]", "Sec23/Sec24 helical domain superfamily [IPR036175]", "Sec7 domain superfamily [IPR035999]", "Sec7, C-terminal domain superfamily [IPR023394]", "SecY domain superfamily [IPR023201]", "Secretoglobin superfamily [IPR035960]", "Sema domain superfamily [IPR036352]", "Serine carboxypeptidase S28, SKS domain [IPR042269]", "Serine-tRNA synthetase, type1, N-terminal domain superfamily [IPR042103]", "Serpin superfamily [IPR036186]", "Serpin superfamily, domain 1 [IPR042178]", "Serpin superfamily, domain 2 [IPR042185]", "Set2 Rpb1 interacting domain superfamily [IPR038190]", "Signal recognition particle SRP54, N-terminal domain superfamily [IPR042101]", "Signal recognition particle, SRP54 subunit, M-domain superfamily [IPR036891]", "Signal recognition particle, SRP9/SRP14 subunit [IPR009018]", "Sin3 associated polypeptide p18 superfamily [IPR042534]", "Single hybrid motif [IPR011053]", "Six-bladed beta-propeller, TolB-like [IPR011042]", "Six-hairpin glycosidase superfamily [IPR008928]", "Six-hairpin glycosidase-like superfamily [IPR012341]", "Smaug, PHAT domain superfamily [IPR037093]", "Sodium/glucose symporter superfamily [IPR038377]", "Sodium/potassium-transporting ATPase subunit beta superfamily [IPR038702]", "Sodium:dicarboxylate symporter superfamily [IPR036458]", "Spermadhesin, CUB domain superfamily [IPR035914]", "Spermidine synthase, tetramerisation domain superfamily [IPR037163]", "Spt6, Death-like domain [IPR042066]", "Stathmin superfamily [IPR036002]", "Sterile alpha motif/pointed domain superfamily [IPR013761]", "Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain superfamily [IPR027477]", "Succinyl-CoA synthetase-like [IPR016102]", "Sulfhydryl oxidase, flavin adenine dinucleotide (FAD) binding domain superfamily [IPR042568]", "Sushi/SCR/CCP superfamily [IPR035976]", "TAP42/TAP46-like superfamily [IPR038511]", "TBP domain superfamily [IPR012295]", "TCP-1-like chaperonin intermediate domain superfamily [IPR027410]", "TEL2, C-terminal domain superfamily [IPR038528]", "TFIIIC, subcomplex tauA subunit Sfc1, triple barrel domain superfamily [IPR042536]", "TFIIS/LEDGF domain superfamily [IPR035441]", "TGS-like [IPR012676]", "TGS-like domain superfamily [IPR023192]", "TMEM14 superfamily [IPR044890]", "TRAF-like [IPR008974]", "TRF2-interacting telomeric protein/Rap1, C-terminal domain superfamily [IPR038104]", "TROVE domain superfamily [IPR037214]", "Talin, central domain superfamily [IPR036476]", "Taurine dioxygenase TauD-like superfamily [IPR042098]", "Tautomerase/MIF superfamily [IPR014347]", "Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid [IPR008930]", "Tetrapyrrole methylase superfamily [IPR035996]", "Tetrapyrrole methylase, subdomain 1 [IPR014777]", "Tetrapyrrole methylase, subdomain 2 [IPR014776]", "Tetraspanin, EC2 domain superfamily [IPR008952]", "Tetratricopeptide-like helical domain superfamily [IPR011990]", "Tex-like domain superfamily [IPR023323]", "Tex-like protein, HTH domain superfamily [IPR023319]", "Thiamin diphosphate-binding fold [IPR029061]", "Thiolase-like [IPR016039]", "Thioredoxin-like superfamily [IPR036249]", "Threonyl/alanyl tRNA synthetase, class II-like, putative editing domain superfamily [IPR018163]", "Thymidylate synthase/dCMP hydroxymethylase superfamily [IPR036926]", "Tim10-like domain superfamily [IPR035427]", "Tma16 superfamily [IPR038356]", "Toll/interleukin-1 receptor homology (TIR) domain superfamily [IPR035897]", "Transcription Factor IIF, Rap30/Rap74, interaction [IPR011039]", "Transcription elongation factor S-II, central domain superfamily [IPR036575]", "Transcription factor EnY2 superfamily [IPR038212]", "Transcription termination and cleavage factor, C-terminal domain superfamily [IPR038192]", "Transferrin receptor-like, dimerisation domain superfamily [IPR036757]", "Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II [IPR009014]", "Translation Initiation factor eIF- 4e-like [IPR023398]", "Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal [IPR009001]", "Translation elongation factor EF1B/ribosomal protein S6 [IPR014717]", "Translation elongation factor eEF-1beta-like superfamily [IPR036219]", "Translation initiation factor 2, alpha subunit, C-terminal [IPR024055]", "Translation initiation factor 2, alpha subunit, middle domain superfamily [IPR024054]", "Translation initiation factor 3, subunit 12, N-terminal, eukaryotic [IPR016020]", "Translation initiation factor IF-2, domain 3 superfamily [IPR036925]", "Translation initiation factor IF2/IF5, N-terminal [IPR016189]", "Translation initiation factor IF2/IF5, zinc-binding [IPR016190]", "Translation initiation factor eIF-2B subunit alpha, N-terminal [IPR042528]", "Translation protein SH3-like domain superfamily [IPR008991]", "Translation protein, beta-barrel domain superfamily [IPR009000]", "Translin superfamily [IPR036081]", "Translin, C-terminal [IPR016069]", "Translin, N-terminal [IPR016068]", "Trimeric LpxA-like superfamily [IPR011004]", "Triosephosphate isomerase superfamily [IPR035990]", "TspO/MBR-related superfamily [IPR038330]", "Tubulin binding cofactor A superfamily [IPR036126]", "Tubulin, C-terminal [IPR023123]", "Tubulin/FtsZ, C-terminal [IPR008280]", "Tubulin/FtsZ, GTPase domain superfamily [IPR036525]", "Tubulin/FtsZ-like, C-terminal domain [IPR037103]", "UBA-like superfamily [IPR009060]", "UDP-glucose/GDP-mannose dehydrogenase, C-terminal domain superfamily [IPR036220]", "UROD/MetE-like superfamily [IPR038071]", "Ubiquitin activating enzyme, alpha domain superfamily [IPR023318]", "Ubiquitin-activating enzyme E1, C-terminal domain superfamily [IPR038252]", "Ubiquitin-activating enzyme E1, FCCH domain superfamily [IPR042302]", "Ubiquitin-activating enzyme E1, SCCH domain [IPR042063]", "Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 1 [IPR042449]", "Ubiquitin-activating enzyme [IPR035985]", "Ubiquitin-conjugating enzyme/RWD-like [IPR016135]", "Ubiquitin-like domain superfamily [IPR029071]", "Ubiquitin-protein ligase E3A, N-terminal zinc-binding domain superfamily [IPR042556]", "Ufd1-like, Nn domain [IPR042299]", "Ureohydrolase domain superfamily [IPR023696]", "V-type ATP synthase c/d subunit, domain 3 superfamily [IPR044911]", "V-type ATP synthase subunit c/d subunit superfamily [IPR036079]", "V-type ATPase subunit C/d [IPR035067]", "V-type ATPase subunit E, C-terminal domain superfamily [IPR038495]", "VASP tetramerisation domain superfamily [IPR038023]", "VPS9 domain superfamily [IPR037191]", "Vacuolar ATP synthase subunit C superfamily [IPR036132]", "Vacuolar protein sorting-associated protein 33, domain 3b [IPR043155]", "Vacuolar protein sorting-associated protein 35, C-terminal [IPR042491]", "Vacuolar protein sorting-associated protein IST1-like [IPR042277]", "Valyl-tRNA synthetase, tRNA-binding arm superfamily [IPR037118]", "Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain [IPR009008]", "Vanillyl-alcohol oxidase, C-terminal subdomain 2 [IPR016171]", "Vitamin B12-dependent methionine synthase, activation domain superfamily [IPR037010]", "Vps16, C-terminal domain superfamily [IPR038132]", "Vps53, C-terminal domain superfamily [IPR038260]", "Vta1/Callose synthase, N-terminal domain superfamily [IPR023175]", "WD40-repeat-containing domain superfamily [IPR036322]", "WD40/YVTN repeat-like-containing domain superfamily [IPR015943]", "WGR domain superfamily [IPR036930]", "WW domain superfamily [IPR036020]", "WWE domain superfamily [IPR037197]", "Winged helix DNA-binding domain superfamily [IPR036390]", "Winged helix-like DNA-binding domain superfamily [IPR036388]", "XPC-binding domain superfamily [IPR036353]", "YEATS superfamily [IPR038704]", "YjeF N-terminal domain superfamily [IPR036652]", "YqgF/RNase H-like domain superfamily [IPR037027]", "ZPR1, A/B domain [IPR042451]", "ZPR1, zinc finger domain [IPR042452]", "Zinc finger C2H2 superfamily [IPR036236]", "Zinc finger, C2H2C-type superfamily [IPR036060]", "Zinc finger, CCCH-type superfamily [IPR036855]", "Zinc finger, CCHC-type superfamily [IPR036875]", "Zinc finger, FYVE/PHD-type [IPR011011]", "Zinc finger, NHR/GATA-type [IPR013088]", "Zinc finger, PARP-type superfamily [IPR036957]", "Zinc finger, RING/FYVE/PHD-type [IPR013083]", "Zinc finger, RanBP2-type superfamily [IPR036443]", "Zinc finger, Sec23/Sec24-type superfamily [IPR036174]", "Zinc finger, ZZ-type superfamily [IPR043145]", "Zinc-binding ribosomal protein [IPR011332]", "dUTPase-like superfamily [IPR036157]", "eRF1, domain 1 [IPR024049]", "eRF1, domain 2 superfamily [IPR042226]", "p53-like tetramerisation domain superfamily [IPR036674]", "p53-like transcription factor, DNA-binding [IPR008967]", "p53/RUNT-type transcription factor, DNA-binding domain superfamily [IPR012346]", "rRNA adenine dimethylase-like, C-terminal [IPR023165]", "ssDNA-binding transcriptional regulator [IPR009044]", "tRNA (guanine-N1-)-methyltransferase, N-terminal [IPR029026]", "tRNA methyltransferase TRM10-type domain superfamily [IPR038459]", "tRNA methyltransferase, Trm1, C-terminal [IPR042296]", "tRNA modification GTPase MnmE domain 2 [IPR027368]", "tRNA uridine 5-carboxymethylaminomethyl modification enzyme, C-terminal subdomain [IPR044920]", "tRNA-splicing ligase RtcB-like superfamily [IPR036025]", "von Willebrand factor A-like domain superfamily [IPR036465]"], "available_proteins": ["AAAS", "AAR2", "AARS", "AARS2", "AASDHPPT", "AASS", "ABCB1", "ABCB10", "ABCB6", "ABCB7", "ABCB8", "ABCC4", "ABCD3", "ABCE1", "ABCF1", "ABCF2", "ABCF3", "ABHD10", "ABHD12", "ABHD14B", "ABHD6", "ABRACL", "ACAA1", "ACAA2", "ACACA", "ACACB", "ACAD11", "ACAD9", "ACADM", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACBD5", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT8", "ACOT9", "ACOX1", "ACOX3", "ACP1", "ACP2", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACSL6", "ACTL6A", "ACTN1", "ACTN4", "ACTR1A", "ACTR1B", "ACTR2", "ACTR3", "ACTR8", "ADA", "ADAR", "ADD1", "ADD3", "ADH5", "ADI1", "ADK", "ADNP", "ADPGK", "ADRM1", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGK", "AGL", "AGPS", "AHCTF1", "AHCY", "AHCYL1", "AHNAK", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AK3", "AK4", "AK6", "AKAP1", "AKAP10", "AKR1A1", "AKR1B1", "AKR7A2", "AKT2", "ALDH16A1", "ALDH18A1", "ALDH1A2", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALG5", "ALKBH5", "ALYREF", "ANAPC1", "ANAPC2", "ANAPC4", "ANAPC5", "ANAPC7", "ANGEL1", "ANK3", "ANKFY1", "ANKHD1", "ANKLE2", "ANKRD17", "ANLN", "ANP32A", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA4", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP1M1", "AP1S1", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "APEH", "APEX1", "API5", "APMAP", "APP", "APPL1", "APRT", "AQR", "ARCN1", "ARF4", "ARF6", "ARFGAP1", "ARFIP1", "ARFIP2", "ARG2", "ARHGAP17", "ARHGDIA", "ARHGEF2", "ARID1A", "ARID2", "ARID3B", "ARIH2", "ARL1", "ARL2", "ARL3", "ARL8A", "ARMC1", "ARMC10", "ARMC6", "ARMCX3", "ARMT1", "ARPC1A", "ARPC2", "ARPC3", "ARPC4", "ARVCF", "ASB6", "ASCC2", "ASCC3", "ASH2L", "ASNA1", "ASNS", "ASPH", "ASPSCR1", "ATAD1", "ATAD2", "ATAD3A", "ATAD3B", "ATAD5", "ATIC", "ATL2", "ATP13A1", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP2B4", "ATP2C1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5H", "ATP5O", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1E1", "ATP6V1H", "ATP7A", "ATP7B", "ATXN10", "AURKA", "BABAM1", "BAG3", "BAG4", "BAG5", "BAG6", "BAIAP2", "BANF1", "BAP18", "BARD1", "BAZ1A", "BAZ1B", "BAZ2A", "BCAS3", "BCKDK", "BCL2L12", "BCR", "BCS1L", "BIRC6", "BLM", "BLMH", "BLVRA", "BMS1", "BOLA2*", "BOP1", "BPTF", "BRAP", "BRCA1", "BRD1", "BRD2", "BRD4", "BSG", "BTAF1", "BTF3", "BUB1B", "BUB3", "BUD23", "BZW1", "BZW2", "C1QBP", "C2CD5", "CAB39", "CACYBP", "CAD", "CALR", "CALU", "CAMK2G", "CAMSAP3", "CAND1", "CAND2", "CANT1", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPNS1", "CAPZA1", "CAPZB", "CARHSP1", "CARS", "CASK", "CBR1", "CBX1", "CBX2", "CBX3", "CBX5", "CBX8", "CC2D1A", "CCAR1", "CCAR2", "CCNB1", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2AP", "CD2BP2", "CD47", "CDC16", "CDC23", "CDC27", "CDC37", "CDC42", "CDC5L", "CDC73", "CDH2", "CDIPT", "CDK1", "CDK12", "CDK2", "CDK4", "CDK5", "CDK5RAP1", "CDK6", "CDK9", "CDKAL1", "CDKN2A", "CEBPZ", "CELF1", "CELF2", "CENPB", "CENPV", "CEP170", "CEP72", "CERS2", "CERS5", "CETN2", "CFL1", "CFL2", "CHAC2", "CHAF1B", "CHAMP1", "CHD1", "CHD1L", "CHD4", "CHD8", "CHDH", "CHERP", "CHID1", "CHKA", "CHORDC1", "CHRAC1", "CHTF18", "CIAPIN1", "CIB1", "CIP2A", "CIRBP", "CISD2", "CIT", "CIZ1", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLASP2", "CLCN3", "CLCN7", "CLGN", "CLIC1", "CLINT1", "CLNS1A", "CLPB", "CLPP", "CLPX", "CLTC", "CLUH", "CMAS", "CMPK1", "CMTR1", "CNN2", "CNN3", "CNNM4", "CNOT1", "CNOT4", "CNOT9", "CNP", "COA7", "COL4A3BP", "COLEC12", "COLGALT1", "COMT", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS2", "COPS3", "COPS4", "COPZ1", "COQ8A", "CORO1B", "CORO1C", "CORO7", "COTL1", "COX15", "COX2", "COX4I1", "COX5A", "COX5B", "COX6C", "COX7A2", "COX7A2L", "CPD", "CPNE1", "CPNE2", "CPNE3", "CPNE8", "CPOX", "CPSF1", "CPSF2", "CPSF3", "CPSF6", "CPSF7", "CPT1A", "CPT2", "CPVL", "CRK", "CRKL", "CRNKL1", "CRTAP", "CRYZ", "CS", "CSDE1", "CSE1L", "CSGALNACT2", "CSK", "CSNK1A1", "CSNK2A1", "CSNK2A2", "CSNK2B", "CSTF1", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTNNA1", "CTNNAL1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTPS2", "CTR9", "CTSA", "CTSC", "CTTN", "CTU2", "CUL1", "CUL2", "CUL3", "CUL4A", "CUL4B", "CUL5", "CUTA", "CWC22", "CWF19L1", "CXADR", "CXorf57", "CYB5B", "CYB5R1", "CYB5R3", "CYC1", "CYP20A1", "CYP51A1", "DAGLB", "DAP3", "DARS", "DARS2", "DAZAP1", "DBN1", "DBNL", "DBT", "DCAF1", "DCAF13", "DCAF7", "DCAF8", "DCAKD", "DCP1B", "DCPS", "DCTD", "DCTN1", "DCUN1D1", "DCUN1D5", "DCXR", "DDB1", "DDI2", "DDRGK1", "DDT", "DDX1", "DDX10", "DDX17", "DDX18", "DDX20", "DDX21", "DDX23", "DDX24", "DDX27", "DDX28", "DDX39A", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX50", "DDX51", "DDX52", "DDX54", "DDX56", "DDX6", "DENR", "DERL1", "DERL2", "DFFA", "DHCR24", "DHFR", "DHPS", "DHRS1", "DHRS13", "DHRS7", "DHRS7B", "DHTKD1", "DHX15", "DHX16", "DHX29", "DHX30", "DHX36", "DHX37", "DHX38", "DHX40", "DHX57", "DHX8", "DHX9", "DIAPH1", "DIAPH2", "DIAPH3", "DICER1", "DIDO1", "DIEXF", "DIMT1", "DIS3", "DKC1", "DLAT", "DLD", "DLG1", "DLST", "DNA2", "DNAAF5", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC13", "DNAJC16", "DNAJC2", "DNAJC21", "DNAJC3", "DNAJC7", "DNAJC8", "DNAJC9", "DNM1L", "DNM2", "DNMT1", "DOCK7", "DOHH", "DOLPP1", "DPF2", "DPH2", "DPH5", "DPM1", "DPP9", "DPYSL2", "DPYSL3", "DPYSL5", "DRG1", "DRG2", "DSC3", "DSCR3", "DSG2", "DSP", "DST", "DSTN", "DTX3L", "DTYMK", "DUS2", "DUSP12", "DUSP3", "DUSP9", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNC2H1", "DYNLL1", "DYNLL2", "EARS2", "ECE1", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "EDC3", "EDC4", "EDF1", "EEA1", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EFCAB14", "EFL1", "EFTUD2", "EHBP1", "EHD1", "EHD4", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2D", "EIF2S1", "EIF2S2", "EIF3B", "EIF3E", "EIF3G", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E", "EIF4E2", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "ELAC2", "ELAVL1", "ELL", "ELMO2", "ELOA", "ELOB", "ELP1", "ELP2", "ELP3", "ELP4", "EMC1", "EMC2", "EMC7", "EMD", "EMG1", "EML4", "ENAH", "ENDOD1", "ENO1", "ENO2", "ENY2", "EP400", "EPB41", "EPB41L2", "EPB41L3", "EPB41L5", "EPHA7", "EPHX1", "EPHX2", "EPN1", "EPPK1", "EPRS", "EPS15L1", "ERAL1", "ERAP1", "ERAP2", "ERBIN", "ERC1", "ERCC2", "ERCC3", "ERCC6L", "ERH", "ERLIN1", "ERLIN2", "ERO1A", "ERO1B", "ERP29", "ESD", "ESF1", "ESYT1", "ESYT2", "ETF1", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXD2", "EXO1", "EXOC2", "EXOC3", "EXOC6", "EXOC7", "EXOC8", "EXOSC1", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC8", "EXOSC9", "EYA4", "EZR", "F11R", "FADS2", "FAF1", "FAF2", "FAH", "FAHD1", "FAHD2A", "FAM120A", "FAM129B", "FAR1", "FARP1", "FARP2", "FARSA", "FARSB", "FASN", "FBL", "FDFT1", "FDPS", "FDXR", "FEN1", "FERMT2", "FH", "FHOD1", "FIS1", "FKBP10", "FKBP14", "FKBP4", "FKBP5", "FKBP7", "FKBP8", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FMR1", "FNBP4", "FNDC3A", "FNTB", "FOCAD", "FOXC1", "FOXK1", "FOXRED1", "FRYL", "FSCN1", "FSD1", "FTO", "FTSJ3", "FUBP1", "FUBP3", "FUCA1", "FUCA2", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GADD45GIP1", "GAK", "GALK1", "GALM", "GALNS", "GALNT1", "GALNT2", "GALNT4", "GALNT7", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2B", "GATB", "GBA", "GBF1", "GCAT", "GCDH", "GCLC", "GCN1", "GDAP1", "GDI1", "GDI2", "GDPD1", "GEMIN5", "GET4", "GFM1", "GFPT1", "GGA1", "GGCT", "GGCX", "GGH", "GGT7", "GIGYF2", "GINS2", "GINS3", "GINS4", "GLA", "GLB1", "GLDC", "GLE1", "GLO1", "GLOD4", "GLRX3", "GLRX5", "GLS", "GLTP", "GLUD1", "GLYR1", "GM2A", "GMFB", "GMPS", "GNA13", "GNAI1", "GNAI2", "GNAI3", "GNAQ", "GNE", "GNG12", "GNG5", "GNL1", "GNL2", "GNL3", "GNL3L", "GNPDA1", "GNPNAT1", "GNS", "GORASP2", "GOT1", "GOT2", "GPATCH8", "GPD1L", "GPD2", "GPHN", "GPI", "GPKOW", "GPRASP2", "GPS1", "GPT2", "GPX8", "GRB2", "GRHPR", "GRPEL1", "GRSF1", "GRWD1", "GSK3B", "GSPT1", "GSR", "GSS", "GSTK1", "GSTM3", "GSTO1", "GSTZ1", "GTF2E1", "GTF2E2", "GTF2F1", "GTF2H1", "GTF2I", "GTF3C2", "GTF3C3", "GTF3C4", "GTF3C5", "GTPBP1", "GTPBP10", "GTPBP3", "GTPBP4", "GUF1", "GXYLT1", "GYG1", "H1F0", "H1FX", "H2AFY", "H2AFY2", "H4C1*", "HACD3", "HACL1", "HADH", "HADHA", "HADHB", "HARS2", "HAT1", "HBS1L", "HCFC1", "HDAC1", "HDAC2", "HDGFL2", "HDHD2", "HDHD5", "HDLBP", "HEATR1", "HEATR3", "HEATR6", "HEBP1", "HECTD1", "HECTD3", "HELLS", "HEXA", "HEXB", "HGH1", "HGS", "HIBADH", "HIBCH", "HINT2", "HINT3", "HIRA", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLTF", "HMBS", "HMCES", "HMGB1", "HMGB2", "HMGB3", "HMGCL", "HMGCR", "HMGCS1", "HMOX1", "HMOX2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPLL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HNRNPUL2", "HOOK2", "HOOK3", "HP1BP3", "HPRT1", "HS2ST1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSD17B7", "HSDL1", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA13", "HSPA14", "HSPA1B", "HSPA2", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPBP1", "HSPD1", "HSPE1", "HSPH1", "HTATSF1", "HTT", "HUWE1", "HYOU1", "IARS", "IARS2", "IDE", "IDI1", "IFIT5", "IFT27", "IFT81", "IGBP1", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IKBKB", "ILF2", "ILF3", "ILK", "ILKAP", "ILVBL", "IMP3", "IMPDH1", "IMPDH2", "INF2", "INPP4A", "INPPL1", "INTS1", "INTS11", "INTS14", "INTS4", "INTS7", "INTS8", "INTS9", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQCB1", "IQGAP1", "IQGAP3", "IRF2BPL", "IRS4", "ISG20L2", "ISOC1", "IST1", "ISY1", "ISYNA1", "ITCH", "ITGB1", "ITPA", "ITSN2", "IVD", "IWS1", "JUP", "KARS", "KAT7", "KCTD12", "KDELC2", "KDM1A", "KDM1B", "KDM2A", "KDM5A", "KDSR", "KHDRBS1", "KHDRBS3", "KHSRP", "KIAA0319L", "KIAA0368", "KIAA0391", "KIAA1468", "KIDINS220", "KIF11", "KIF14", "KIF18A", "KIF18B", "KIF1A", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF3A", "KIF4A", "KIF5B", "KIFBP", "KIN", "KLC1", "KLC4", "KLHL11", "KMT2A", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNA6", "KPNB1", "KRR1", "KYAT3", "L2HGDH", "LACTB", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LASP1", "LDAH", "LDHA", "LDHB", "LDLR", "LEMD3", "LETM1", "LGALS3", "LGALS3BP", "LIG1", "LIG3", "LIPA", "LLGL1", "LMAN2", "LMAN2L", "LMNA", "LMNB1", "LMNB2", "LNPEP", "LONP1", "LPCAT1", "LRBA", "LRP1", "LRPAP1", "LRPPRC", "LRRC1", "LRRC40", "LRRC47", "LRRC57", "LRRC59", "LRRC8C", "LRSAM1", "LRWD1", "LSM14B", "LSM2", "LSM4", "LSM6", "LSM7", "LSS", "LTA4H", "LTN1", "LYAR", "LYN", "LYPLA1", "M6PR", "MACF1", "MAGED2", "MAGT1", "MALT1", "MAN2A1", "MAN2B1", "MANF", "MAP1A", "MAPK1", "MAPK14", "MAPRE1", "MAPRE2", "MARC1", "MARCH5", "MARS", "MARS2", "MAT2A", "MAT2B", "MATR3", "MAU2", "MAVS", "MBD3", "MCAM", "MCCC1", "MCCC2", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MDC1", "MDH1", "MDH2", "MDN1", "ME1", "ME2", "MECP2", "MEPCE", "METAP1", "METAP2", "METTL13", "METTL3", "METTL7B", "METTL9", "MFN1", "MFN2", "MFSD10", "MFSD3", "MFSD5", "MGEA5", "MGST2", "MGST3", "MIA2", "MIA3", "MICU1", "MIF", "MINDY3", "MINPP1", "MIPEP", "MKI67", "MKLN1", "MKRN2", "MMAB", "MMS19", "MOCOS", "MOGS", "MON2", "MORC2", "MORF4L1", "MORF4L2", "MOSPD2", "MOV10", "MPG", "MPHOSPH8", "MPI", "MPP1", "MPP2", "MPP6", "MPP7", "MPRIP", "MPST", "MRC2", "MRE11", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL14", "MRPL15", "MRPL17", "MRPL19", "MRPL2", "MRPL20", "MRPL21", "MRPL22", "MRPL24", "MRPL28", "MRPL3", "MRPL38", "MRPL39", "MRPL43", "MRPL44", "MRPL45", "MRPL46", "MRPL47", "MRPL48", "MRPL9", "MRPS11", "MRPS16", "MRPS18A", "MRPS25", "MRPS27", "MRPS5", "MRPS7", "MRPS9", "MRRF", "MRTO4", "MSH2", "MSH3", "MSH6", "MSI1", "MSI2", "MSN", "MSTO1", "MTA1", "MTA2", "MTAP", "MTCH1", "MTCH2", "MTHFD1", "MTHFD1L", "MTHFD2", "MTHFS", "MTMR14", "MTMR2", "MTMR6", "MTO1", "MTOR", "MTPAP", "MTPN", "MTR", "MTX1", "MTX2", "MTX3", "MUL1", "MUT", "MVD", "MYBBP1A", "MYCBP2", "MYEF2", "MYH10", "MYH14", "MYH9", "MYL6", "MYO18A", "MYO1B", "MYO1C", "MYO1D", "MYO6", "NAA10", "NAA15", "NAA25", "NAA40", "NAA50", "NAE1", "NAF1", "NAGLU", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NAPG", "NARS", "NASP", "NAT10", "NAXE", "NBAS", "NBN", "NCAPD2", "NCAPD3", "NCAPG", "NCAPG2", "NCBP1", "NCBP3", "NCDN", "NCEH1", "NCKIPSD", "NCL", "NCOA5", "NCOR1", "NDC80", "NDRG3", "NDUFA10", "NDUFA9", "NDUFAF3", "NDUFAF7", "NDUFS1", "NDUFS3", "NDUFV1", "NDUFV2", "NECAP2", "NEDD1", "NEDD4L", "NEK9", "NELFE", "NENF", "NF1", "NFATC2IP", "NFKBIL1", "NFS1", "NFU1", "NHLRC2", "NHP2", "NIFK", "NIP7", "NIPBL", "NIPSNAP1", "NIPSNAP2", "NISCH", "NIT2", "NKRF", "NKTR", "NLE1", "NLN", "NLRX1", "NME1", "NME2", "NMT1", "NNT", "NOA1", "NOB1", "NOC2L", "NOC3L", "NOC4L", "NOL10", "NOL11", "NOL8", "NOL9", "NOM1", "NONO", "NOP2", "NOP56", "NOP58", "NOP9", "NOSIP", "NOTCH2", "NPC2", "NPEPPS", "NPLOC4", "NPM1", "NRBP1", "NRDC", "NRDE2", "NRP1", "NSD1", "NSD2", "NSD3", "NSDHL", "NSF", "NSMCE2", "NSUN2", "NT5C2", "NT5C3A", "NT5C3B", "NT5DC1", "NT5DC2", "NTHL1", "NTMT1", "NTPCR", "NUB1", "NUBP2", "NUBPL", "NUCB1", "NUCB2", "NUDC", "NUDCD1", "NUDCD2", "NUDCD3", "NUDT1", "NUDT16L1", "NUDT21", "NUDT5", "NUF2", "NUP133", "NUP153", "NUP155", "NUP188", "NUP210", "NUP214", "NUP35", "NUP37", "NUP43", "NUP50", "NUP98", "NUTF2", "NVL", "NXF1", "NXN", "OARD1", "OAT", "OCLN", "OCRL", "OGDH", "OGT", "OLA1", "OPA1", "ORC5", "OSBP", "OSBPL11", "OSBPL1A", "OSBPL6", "OSBPL8", "OSBPL9", "OSGEP", "OSTF1", "OTUB1", "OXSR1", "P3H1", "P3H4", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PAFAH1B1", "PAFAH1B2", "PAFAH1B3", "PAK1IP1", "PAK2", "PALD1", "PALLD", "PANK4", "PAPOLA", "PAPSS1", "PARD3", "PARK7", "PARN", "PARP1", "PARP2", "PBDC1", "PBK", "PBRM1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCMT1", "PCYOX1", "PDCD11", "PDCD5", "PDCD6", "PDCD6IP", "PDCL3", "PDE12", "PDHA1", "PDHB", "PDHX", "PDIA3", "PDIA4", "PDIA6", "PDK1", "PDK3", "PDLIM1", "PDLIM5", "PDP1", "PDS5A", "PDS5B", "PDSS2", "PDXDC1", "PDZD8", "PEBP1", "PECR", "PEF1", "PELO", "PELP1", "PEPD", "PES1", "PEX14", "PEX19", "PFAS", "PFDN2", "PFDN4", "PFDN5", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGM3", "PGP", "PGRMC1", "PGRMC2", "PHB", "PHB2", "PHF10", "PHF2", "PHF3", "PHF6", "PHGDH", "PHIP", "PHKA1", "PHKB", "PI4KA", "PI4KB", "PICALM", "PIGG", "PIK3C2A", "PIK3R2", "PIK3R4", "PIN1", "PIP4K2C", "PIR", "PITHD1", "PITPNA", "PITPNB", "PITRM1", "PKM", "PKMYT1", "PKN1", "PKN2", "PLA2G15", "PLAA", "PLBD2", "PLCG1", "PLEC", "PLEKHA5", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLRG1", "PLS3", "PLXNB2", "PM20D2", "PMPCA", "PMPCB", "PMVK", "PNKP", "PNO1", "PNP", "PNPLA6", "PNPLA8", "PNPT1", "POGZ", "POLA1", "POLA2", "POLD1", "POLDIP2", "POLDIP3", "POLE", "POLG", "POLR1A", "POLR1B", "POLR1C", "POLR2A", "POLR2B", "POLR2C", "POLR2D", "POLR2E", "POLR2G", "POLR2L", "POLR3A", "POLR3B", "POLR3C", "POLRMT", "PON2", "POP4", "POR", "PPA1", "PPA2", "PPAT", "PPCDC", "PPFIA1", "PPIB", "PPIC", "PPID", "PPIE", "PPIF", "PPIG", "PPIH", "PPIL4", "PPM1G", "PPME1", "PPOX", "PPP1CA", "PPP1CB", "PPP1R10", "PPP1R7", "PPP1R8", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP2R5E", "PPP3CA", "PPP4R1", "PPP4R3A", "PPP5C", "PPP6C", "PPP6R3", "PPT1", "PPWD1", "PQBP1", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PREP", "PREPL", "PRKAA1", "PRKAA2", "PRKACA", "PRKAR1A", "PRKAR2A", "PRKCB", "PRKCSH", "PRKDC", "PRMT1", "PRMT3", "PRMT5", "PRMT9", "PRPF19", "PRPF3", "PRPF31", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPS2", "PRPSAP1", "PRPSAP2", "PRRC1", "PSAP", "PSAT1", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD12", "PSMD13", "PSMD2", "PSMD3", "PSMD4", "PSMD6", "PSME1", "PSME2", "PSME3", "PSME4", "PSMG2", "PSPC1", "PTBP1", "PTBP2", "PTCD1", "PTCD3", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK2", "PTK7", "PTPA", "PTPN1", "PTPN11", "PTPN23", "PTPRF", "PTRH2", "PUF60", "PUM3", "PUS1", "PUS7", "PUS7L", "PWP1", "PWP2", "PYCR1", "PYCR2", "QARS", "QDPR", "QKI", "QRSL1", "QSOX2", "QTRT2", "R3HCC1", "RAB10", "RAB12", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB1B", "RAB23", "RAB24", "RAB2A", "RAB34", "RAB35", "RAB3B", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RAB8A", "RAB9A", "RABEPK", "RABGAP1", "RABGGTA", "RABL3", "RABL6", "RAC1", "RACGAP1", "RACK1", "RAD18", "RAD21", "RAD23A", "RAD23B", "RAD50", "RAD54L2", "RAE1", "RAI14", "RALA", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP6", "RANBP9", "RANGAP1", "RAP1GDS1", "RAPGEF2", "RARS", "RARS2", "RAVER1", "RBBP4", "RBBP5", "RBBP6", "RBBP7", "RBM10", "RBM12", "RBM12B", "RBM14", "RBM17", "RBM19", "RBM22", "RBM25", "RBM26", "RBM27", "RBM28", "RBM3", "RBM34", "RBM39", "RBM4", "RBM45", "RBM47", "RBM5", "RBM6", "RBM8A", "RBMX", "RBMXL1", "RBPJ", "RCC1", "RCC2", "RCL1", "RCN1", "RCN2", "RDH11", "RDH13", "RDH14", "RDX", "RECQL", "RETSAT", "REXO2", "REXO4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RHBDD2", "RHEB", "RHOG", "RHOT1", "RHOT2", "RIDA", "RIF1", "RINT1", "RIPK1", "RMDN1", "RMDN3", "RNASEH2A", "RNASET2", "RNF2", "RNF20", "RNF40", "RNMT", "RNPEP", "RNPS1", "ROBO1", "ROCK1", "ROCK2", "RP2", "RPA1", "RPA2", "RPAP3", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL3", "RPL30", "RPL31", "RPL32", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPP30", "RPP38", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS26", "RPS28", "RPS29", "RPS3", "RPS4X", "RPS5", "RPS6KA1", "RPS6KA3", "RPS8", "RPS9", "RPSA", "RPTOR", "RPUSD3", "RRAS2", "RREB1", "RRM1", "RRM2", "RRP12", "RRP8", "RRP9", "RSF1", "RSL1D1", "RSL24D1", "RSPRY1", "RSU1", "RTCA", "RTCB", "RTN4IP1", "RUFY1", "RUVBL1", "RUVBL2", "S100A11", "S100A13", "SAAL1", "SAE1", "SAFB", "SAFB2", "SALL2", "SAMD4B", "SAMHD1", "SAP18", "SAR1A", "SAR1B", "SARM1", "SARNP", "SARS", "SARS2", "SART3", "SBDS", "SBNO1", "SCAF11", "SCAF4", "SCCPDH", "SCFD1", "SCFD2", "SCML2", "SCO1", "SCO2", "SCP2", "SCPEP1", "SCRIB", "SCYL1", "SDAD1", "SDF4", "SDHA", "SDHB", "SDHC", "SDR39U1", "SEC11A", "SEC22B", "SEC23A", "SEC23B", "SEC23IP", "SEC24A", "SEC24B", "SEC24C", "SEC31A", "SEC61A1", "SEC63", "SEH1L", "SEL1L", "SENP3", "SEPT11", "SEPT2", "SEPT7", "SEPT9", "SERPINB6", "SERPINH1", "SET", "SETD1A", "SETD2", "SETD3", "SETDB1", "SEZ6L2", "SF1", "SF3A1", "SF3A2", "SF3B1", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFSWAP", "SGPL1", "SGTA", "SH3GL1", "SH3GLB1", "SHCBP1", "SHMT1", "SHMT2", "SIN3A", "SKA1", "SKIV2L", "SKIV2L2", "SKP1", "SKP2", "SLC16A1", "SLC19A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A16", "SLC25A17", "SLC25A19", "SLC25A20", "SLC25A21", "SLC25A24", "SLC25A25", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A33", "SLC25A4", "SLC25A44", "SLC25A5", "SLC25A6", "SLC27A4", "SLC33A1", "SLC3A2", "SLC4A1AP", "SLC4A2", "SLC5A6", "SLC9A3R1", "SLFN11", "SLIRP", "SLIT2", "SLK", "SLMAP", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCC1", "SMARCC2", "SMARCD1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC5", "SMC6", "SMCHD1", "SMG1", "SMG5", "SMS", "SMU1", "SND1", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPC", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNU13", "SNX1", "SNX17", "SNX19", "SNX2", "SNX27", "SNX3", "SNX5", "SNX6", "SNX9", "SOD2", "SON", "SORD", "SORT1", "SPAG9", "SPART", "SPATA5", "SPATA5L1", "SPATS2L", "SPECC1L", "SPEN", "SPNS1", "SPOUT1", "SPR", "SPRYD4", "SPTAN1", "SPTBN1", "SPTLC1", "SPTLC2", "SQLE", "SRC", "SRCAP", "SREK1", "SRI", "SRM", "SRP14", "SRP54", "SRP68", "SRP72", "SRP9", "SRPK1", "SRPK2", "SRPRA", "SRPRB", "SRRM1", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF3", "SRSF4", "SRSF5", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSRP1", "STAG1", "STAG2", "STAM", "STAM2", "STAT1", "STAT3", "STIP1", "STK26", "STK3", "STK4", "STMN1", "STOM", "STOML2", "STRAP", "STRBP", "STRN", "STUB1", "STX10", "STX12", "STX16", "STX4", "STX7", "STXBP2", "STXBP3", "STXBP4", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGP2", "SUGT1", "SUPT16H", "SUPT3H", "SUPT5H", "SUPT6H", "SUPV3L1", "SV2A", "SYAP1", "SYMPK", "SYNCRIP", "SYNE1", "SYNE2", "SYNJ2BP", "TAB1", "TAF15", "TAF6", "TAGLN2", "TALDO1", "TAP1", "TAP2", "TARBP1", "TARDBP", "TARS", "TARS2", "TARSL2", "TBC1D13", "TBC1D15", "TBC1D4", "TBC1D9B", "TBCA", "TBCB", "TBCD", "TBCE", "TBL1XR1", "TBL2", "TBL3", "TCAF1", "TCEA1", "TCERG1", "TCP1", "TDRKH", "TECR", "TEFM", "TELO2", "TERF2IP", "TEX10", "TEX264", "TFAM", "TFB1M", "TFCP2", "TFRC", "THADA", "THEM6", "THOC1", "THOC3", "THOC6", "THOP1", "THYN1", "TIA1", "TIAL1", "TIGAR", "TIMM10B", "TIMM44", "TIMM50", "TIMM8B", "TJP1", "TJP2", "TK1", "TKT", "TLE3", "TLK2", "TLN1", "TMA16", "TMED2", "TMED7", "TMEM115", "TMEM14C", "TMLHE", "TMOD3", "TMPO", "TMPO", "TMPPE", "TMTC3", "TMX1", "TMX2", "TMX3", "TNPO1", "TNPO2", "TNPO3", "TOE1", "TOMM20", "TOMM34", "TOMM40", "TOMM70", "TOP1", "TOP2A", "TOP2B", "TOPBP1", "TOR1A", "TOR1AIP1", "TOR1AIP2", "TOR1B", "TOX4", "TP53", "TP53BP1", "TP53BP2", "TPBG", "TPD52L2", "TPI1", "TPM4", "TPP1", "TPP2", "TPT1", "TRA2A", "TRA2B", "TRAF2", "TRAP1", "TRAPPC4", "TRAPPC5", "TRIM13", "TRIM21", "TRIM25", "TRIM26", "TRIM27", "TRIM28", "TRIM33", "TRIM4", "TRIO", "TRIP12", "TRIP13", "TRIP4", "TRMT1", "TRMT10C", "TRMT11", "TRMT1L", "TRMT2A", "TRMU", "TROVE2", "TRRAP", "TRUB1", "TSFM", "TSG101", "TSN", "TSNAX", "TSPAN3", "TSPAN6", "TSPO", "TST", "TTC1", "TTC19", "TTC26", "TTC27", "TTC28", "TTC37", "TTC38", "TTC4", "TTF2", "TTK", "TUBB", "TUBB2A", "TUBB2B", "TUBB3", "TUBB4A", "TUBB6", "TUBGCP2", "TUBGCP3", "TUFM", "TWF2", "TWNK", "TXNDC12", "TXNDC15", "TXNDC17", "TXNDC5", "TXNDC9", "TXNL1", "TXNRD1", "TYMS", "U2AF1", "U2AF2", "U2SURP", "UAP1", "UBA1", "UBA2", "UBA3", "UBA6", "UBAC1", "UBAP2L", "UBE2J1", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2O", "UBE2S", "UBE3A", "UBE3C", "UBE4A", "UBFD1", "UBLCP1", "UBQLN4", "UBR2", "UBR4", "UBR5", "UBTF", "UBXN1", "UBXN4", "UBXN7", "UCHL5", "UCK2", "UFC1", "UFD1", "UFM1", "UGCG", "UGDH", "UGGT1", "UGP2", "UHRF1", "UMPS", "UNC45A", "UPF1", "UPF2", "UPF3B", "UQCR10", "UQCRB", "UQCRC1", "UQCRC2", "UQCRFS1", "UQCRQ", "URB1", "URGCP", "UROD", "USO1", "USP10", "USP11", "USP14", "USP19", "USP24", "USP28", "USP36", "USP39", "USP47", "USP48", "USP5", "USP7", "USP9X", "UTP15", "UTP18", "UTP20", "UTP4", "UTP6", "UTRN", "VAMP7", "VAPA", "VAPB", "VARS1", "VARS2", "VAT1", "VBP1", "VCL", "VCP", "VDAC1", "VDAC2", "VDAC3", "VIPAS39", "VIRMA", "VPS16", "VPS26A", "VPS29", "VPS33A", "VPS33B", "VPS35", "VPS37B", "VPS45", "VPS4A", "VPS4B", "VPS51", "VPS53", "VRK1", "VRK3", "VTA1", "WAPL", "WARS", "WDHD1", "WDR1", "WDR11", "WDR12", "WDR18", "WDR26", "WDR3", "WDR33", "WDR36", "WDR4", "WDR41", "WDR43", "WDR46", "WDR5", "WDR6", "WDR61", "WDR7", "WDR73", "WDR74", "WDR75", "WDR77", "WDR82", "WDR91", "WFS1", "WIPI2", "WIZ", "WRAP73", "WRNIP1", "XAB2", "XPNPEP1", "XPNPEP3", "XPO1", "XPO4", "XPO5", "XPO7", "XPOT", "XRCC1", "XRCC5", "XRCC6", "XXYLT1", "YARS", "YARS2", "YEATS2", "YEATS4", "YKT6", "YLPM1", "YME1L1", "YOD1", "YTHDC2", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2", "ZC3H15", "ZC3H18", "ZC3H4", "ZC3H7A", "ZC3HAV1", "ZCCHC11", "ZCCHC3", "ZFR", "ZFYVE16", "ZNF281", "ZNF512B", "ZNF622", "ZNF638", "ZPR1", "ZRANB2", "ZZEF1"], "leading_proteins": ["ABCB10", "ABCB6", "ABCB8", "ABCD3", "ABHD10", "ABHD12", "ACP2", "ADD3", "AGL", "AIFM1", "ANK3", "APMAP", "ARHGAP17", "ATP13A1", "ATP1A1", "ATP2A2", "ATP2B1", "ATP2B4", "ATP2C1", "ATP7A", "ATP7B", "BCKDK", "BSG", "CALU", "CD47", "CETN2", "CIB1", "CLCN7", "CNNM4", "COLEC12", "COX7A2", "CPT2", "CPVL", "CSGALNACT2", "CTSA", "CXADR", "CYB5B", "CYP20A1", "DAGLB", "DERL2", "DHCR24", "DHRS1", "DHRS7", "DLD", "DLG1", "DNAJC16", "ECE1", "EEF1B2", "EFCAB14", "EIF2B5", "EMD", "EPHA7", "ERAL1", "ERAP1", "ERAP2", "ERLIN1", "ERLIN2", "ERO1A", "ETF1", "FAF2", "FDFT1", "FDPS", "FKBP14", "FKBP7", "FLOT1", "FLOT2", "FOXRED1", "FUCA2", "GAA", "GALNS", "GALNT1", "GALNT4", "GBA", "GDAP1", "GGCX", "GGT7", "GINS2", "GLA", "GLB1", "GNAI2", "GNAQ", "GNG5", "GPX8", "HADH", "HADHA", "HEXA", "HLA-A", "HLA-C", "HMOX1", "HSD17B12", "HSD17B4", "HSDL1", "HSDL2", "ILVBL", "KDSR", "KIAA0319L", "KIDINS220", "L2HGDH", "LDAH", "LETM1", "LMNA", "LMNB1", "LNPEP", "LPCAT1", "LRSAM1", "LSS", "LTA4H", "MAN2A1", "MAPRE2", "MAVS", "ME1", "MFSD3", "MIA2", "MIA3", "MICU1", "MIF", "MOGS", "MOSPD2", "MPP2", "MRC2", "MRPL12", "MTCH1", "MTCH2", "MTX1", "MUT", "NAGLU", "NAP1L4", "NBAS", "NCEH1", "NIPSNAP2", "NNT", "NRDC", "NSF", "NT5DC2", "NUB1", "NUCB1", "NUCB2", "OSBP", "OSBPL1A", "OSBPL6", "OSBPL8", "OSBPL9", "PANK4", "PCYOX1", "PDK3", "PFDN2", "PFDN5", "PGRMC2", "PHB", "PHB2", "PHGDH", "PHKA1", "PIGG", "PIR", "PITRM1", "PMPCA", "PNPLA6", "PON2", "PPT1", "PRCP", "PREPL", "PRKAA1", "PRKAR1A", "PSMB2", "PSME3", "PTGES2", "PTPN23", "QSOX2", "RAD23A", "RCN2", "RDH13", "RHBDD2", "RHOT2", "RINT1", "RIPK1", "RTN4IP1", "SCCPDH", "SCFD1", "SCFD2", "SCO1", "SCO2", "SCPEP1", "SDF4", "SDR39U1", "SEC23IP", "SEL1L", "SET", "SH3GLB1", "SLC25A1", "SLC25A10", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A16", "SLC25A19", "SLC25A21", "SLC25A24", "SLC25A25", "SLC25A26", "SLC25A32", "SLC25A33", "SLC25A4", "SLC25A44", "SLC25A6", "SLC33A1", "SNX19", "SNX2", "SNX27", "SNX5", "SNX6", "SPATA5", "SPNS1", "SPOUT1", "SQLE", "SRP9", "STOM", "STX10", "STX7", "STXBP2", "STXBP3", "SV2A", "SYAP1", "TAP1", "TAP2", "TARBP1", "TEX264", "THOC1", "THOP1", "TIMM50", "TIMM8B", "TMED2", "TMPO", "TMX1", "TMX2", "TMX3", "TP53", "TPD52L2", "TRIO", "TSNAX", "TSPAN6", "TUBB", "TUBB2A", "TUBB2B", "TUBB3", "TUBB4A", "TXNDC15", "UBQLN4", "UBXN1", "UGCG", "UQCRC2", "USP24", "USP28", "VDAC1", "VDAC2", "VIPAS39", "VPS33A", "VPS33B", "VPS37B", "YME1L1", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAZ", "ZADH2"]} \ No newline at end of file diff --git a/interpro_ptm/advanced/idx2term.json b/interpro_ptm/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..6b2b1d3e31851c6905a093a9239a9bf9fdb4ccf5 --- /dev/null +++ b/interpro_ptm/advanced/idx2term.json @@ -0,0 +1 @@ +{"0": "P-type ATPase, phosphorylation site [IPR018303]"} \ No newline at end of file diff --git a/interpro_ptm/advanced/plot_0.png b/interpro_ptm/advanced/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..6b41d44a2968d8b7551cf1bd2cf20e7e5d04c687 --- /dev/null +++ b/interpro_ptm/advanced/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:3b08b0892b2a05022169e421092e8f82c53e29ef0a4d2c7cf6bee7cdc0ccb2ea +size 163948 diff --git a/interpro_ptm/basic/idx2term.json b/interpro_ptm/basic/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..6b2b1d3e31851c6905a093a9239a9bf9fdb4ccf5 --- /dev/null +++ b/interpro_ptm/basic/idx2term.json @@ -0,0 +1 @@ +{"0": "P-type ATPase, phosphorylation site [IPR018303]"} \ No newline at end of file diff --git a/interpro_ptm/basic/plot_0.png b/interpro_ptm/basic/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..9703fc96b8c33e0d1ae798f731be021b0104b667 --- /dev/null +++ b/interpro_ptm/basic/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:39c4efe915eeca3ffb6feaffc3dded41c0b5db54ddc069d9144dc51ca562dec4 +size 144585 diff --git a/interpro_ptm/consensus.joblib b/interpro_ptm/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..f21d4077ee225532eb50a7b4c481838cf585c075 --- /dev/null +++ b/interpro_ptm/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:a13b1e88bcf731781295013a5cad50e3ce8c25c27813fd2eb4635b567390f5eb +size 71578 diff --git a/interpro_ptm/df_merge.tsv b/interpro_ptm/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..d29ed1231367de9eb50b4c83d5b0524b6bd72245 --- /dev/null +++ b/interpro_ptm/df_merge.tsv @@ -0,0 +1,2 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +P-type ATPase, phosphorylation site [IPR018303] 7 8 2.548795892583177 0.0108095544235906 2.941747572815534 6.145631067961165 0.9567723497044874 0.2732808833570771 1.8358630293390923 1.459204245106796 1.2102525517005158 0.2943240638910574 0.0001926635075221 1.0 0.191600110602388 0.0152248647419399 0.0004867641084232 diff --git a/interpro_ptm/metrics.json b/interpro_ptm/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..fb73b91127fc74089794926263bedda9dfb0d54d --- /dev/null +++ b/interpro_ptm/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3221, + "annotations_size": 4, + "title": "Average number of proteins per term", + "value": 3.5 +} \ No newline at end of file diff --git a/interpro_ptm/paths.json b/interpro_ptm/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..3282e0e33dc4d89c8544ac5f178d53ed5a2252aa --- /dev/null +++ b/interpro_ptm/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/interpro_ptm/fragment/C201/C201_val_log2fc"} \ No newline at end of file diff --git a/interpro_ptm/result.tsv b/interpro_ptm/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..350fc1eeb6bd38f6502e7c1b5a43cf57e3f7ba55 --- /dev/null +++ b/interpro_ptm/result.tsv @@ -0,0 +1,2 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +P-type ATPase, phosphorylation site [IPR018303] 0.8291316526610572 2.548795892583177 0.0108095544235906 0.0425421774732163 0.0432382176943626 8 P98194,Q9HD20,P20020,P05023,P16615,P35670,Q04656 7 diff --git a/interpro_ptm/selections.json b/interpro_ptm/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..f3248c41980d188290e296fa4536115ba0072732 --- /dev/null +++ b/interpro_ptm/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["EGF-type aspartate/asparagine hydroxylation site [IPR000152]", "P-type ATPase, phosphorylation site [IPR018303]", "Phosphopantetheine attachment site [IPR006162]", "Translation elongation factor, IF5A, hypusine site [IPR019769]"], "available_proteins": ["ATP13A1", "ATP1A1", "ATP2A2", "ATP2B1", "ATP2B4", "ATP2C1", "ATP7A", "ATP7B", "EIF5A", "FASN", "LDLR", "LRP1", "NOTCH2", "SLIT2"], "leading_proteins": ["ATP13A1", "ATP1A1", "ATP2A2", "ATP2B1", "ATP2C1", "ATP7A", "ATP7B"]} \ No newline at end of file diff --git a/interpro_repeat/advanced/idx2term.json b/interpro_repeat/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..6dce773863970e13dd9ed6c0019ab4c4e97de280 --- /dev/null +++ b/interpro_repeat/advanced/idx2term.json @@ -0,0 +1 @@ +{"0": "Mitochondrial substrate/solute carrier [IPR018108]"} \ No newline at end of file diff --git a/interpro_repeat/advanced/plot_0.png b/interpro_repeat/advanced/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..458f04c8c6f0d4774fd2218a2bb0f8907c88ca97 --- /dev/null +++ b/interpro_repeat/advanced/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:00027be31cbd3da917c91c23d3222ba7c6c6afa68ed895558069b1ef68b71f31 +size 183452 diff --git a/interpro_repeat/basic/idx2term.json b/interpro_repeat/basic/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..6dce773863970e13dd9ed6c0019ab4c4e97de280 --- /dev/null +++ b/interpro_repeat/basic/idx2term.json @@ -0,0 +1 @@ +{"0": "Mitochondrial substrate/solute carrier [IPR018108]"} \ No newline at end of file diff --git a/interpro_repeat/basic/plot_0.png b/interpro_repeat/basic/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..7a9dd90a0599f628ded02d68bc324aeb489db44d --- /dev/null +++ b/interpro_repeat/basic/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:1c4e847ad905f1651ad057722326fc2adc852cfb4805008c6e892c32df58d7ac +size 148016 diff --git a/interpro_repeat/consensus.joblib b/interpro_repeat/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..7c5493b4da7a296a5c46eb11f5c77ea0b0d241d6 --- /dev/null +++ b/interpro_repeat/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:eb22397e1b245fd93fc42a5046e26221b7bde3372e590e34cdbbdd34fbe4f794 +size 79508 diff --git a/interpro_repeat/df_merge.tsv b/interpro_repeat/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..63e80fb3224360dd9759dfb139e46fb9e4393a44 --- /dev/null +++ b/interpro_repeat/df_merge.tsv @@ -0,0 +1,2 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Mitochondrial substrate/solute carrier [IPR018108] 18 23 3.713768788843645 0.0002041953667 9.148058252427184 20.71359223300971 2.0411027534642088 0.1411881998864352 5.368907349966936 1.8276489510009888 1.309103123363054 0.2428184236965967 2.3743516116109385e-14 0.0142466262053111 0.005693097574516 2.1183390436798366e-07 2.2571867149562812e-14 diff --git a/interpro_repeat/metrics.json b/interpro_repeat/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..2c71968f188e2ea97800579f74c5efc8480ee426 --- /dev/null +++ b/interpro_repeat/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3221, + "annotations_size": 77, + "title": "Average number of proteins per term", + "value": 5.8441558441558445 +} \ No newline at end of file diff --git a/interpro_repeat/paths.json b/interpro_repeat/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..237b8c010e648f735dafd8ba58f9db744cd8c379 --- /dev/null +++ b/interpro_repeat/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/interpro_repeat/fragment/C201/C201_val_log2fc"} \ No newline at end of file diff --git a/interpro_repeat/result.tsv b/interpro_repeat/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..dc16dbf6e502d2e759479f9320f7e45f2b755a07 --- /dev/null +++ b/interpro_repeat/result.tsv @@ -0,0 +1,7 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Mitochondrial substrate/solute carrier [IPR018108] 0.7950682684119263 3.713768788843645 0.0002041953667 0.0156016619370156 0.0157230432359017 23 Q9BSK2,Q9HC21,Q6NUK1,Q96H78,P12236,Q9UJS0,O75746,Q70HW3,Q9BQT8,Q9UBX3,Q9H2D1,Q9NZJ7,P16260,P53007,P12235,Q9Y6C9,Q6KCM7,Q9Y619 18 +Protein prenyltransferase, alpha subunit [IPR002088] 0.9136377757067392 1.4093893247637457 0.1587200789063019 0.9999983388061128 0.3491841735938642 2 P49354 1 +Spectrin repeat [IPR002017] 0.4092529481493759 0.5137742128574636 0.6074098590037111 1.0 0.754360757406243 10 O75962 1 +Importin repeat 6 [IPR041389] 0.6750543647095336 0.4969296984981149 0.6192386277201303 1.0 0.754360757406243 2 O60518 1 +Importin repeat 4 [IPR041653] 0.6750543647095336 0.4969296984981149 0.6192386277201303 1.0 0.754360757406243 2 O60518 1 +Kinesin light chain repeat [IPR015792] 0.6716371543957645 0.4859520700677612 0.6270011490129812 1.0 0.754360757406243 2 Q9NSK0 1 diff --git a/interpro_repeat/selections.json b/interpro_repeat/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..98525db6bd22ead71fac3fd4c78936d65327db40 --- /dev/null +++ b/interpro_repeat/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["Ankyrin repeat [IPR002110]", "Annexin repeat [IPR018502]", "Armadillo [IPR000225]", "Atypical Arm repeat [IPR032413]", "BIR repeat [IPR001370]", "BspA type Leucine rich repeat region [IPR026906]", "Calponin repeat [IPR000557]", "Cation-independent mannose-6-phosphate receptor repeat [IPR000479]", "Chromosome region maintenance repeat [IPR041123]", "Clathrin, heavy chain, propeller repeat [IPR022365]", "Clathrin, heavy chain/VPS, 7-fold repeat [IPR000547]", "Collagen triple helix repeat [IPR008160]", "Cysteine-rich Golgi apparatus protein 1 repeat [IPR001893]", "Cysteine-rich Golgi apparatus protein 1 repeat, eukaryote [IPR017873]", "Exportin-1, repeat 2 [IPR041235]", "Exportin-1, repeat 3 [IPR040485]", "Filamin/ABP280 repeat [IPR001298]", "Filamin/ABP280 repeat-like [IPR017868]", "Fis1, C-terminal tetratricopeptide repeat [IPR028061]", "Fis1, N-terminal tetratricopeptide repeat [IPR028058]", "G-protein beta WD-40 repeat [IPR020472]", "GTF2I-like repeat [IPR004212]", "HAT (Half-A-TPR) repeat [IPR003107]", "HEAT repeat [IPR000357]", "HEAT repeat associated with sister chromatid cohesion protein [IPR026003]", "HEAT, type 2 [IPR021133]", "HUWE1/Rev1, ubiquitin binding region [IPR025527]", "Hexapeptide repeat [IPR001451]", "Hs1/Cortactin [IPR003134]", "Huntingtin, middle-repeat [IPR024613]", "Importin repeat 4 [IPR041653]", "Importin repeat 6 [IPR041389]", "Importin repeat [IPR040928]", "KI67R [IPR012568]", "Kelch repeat type 1 [IPR006652]", "Kelch repeat type 2 [IPR011498]", "Kinesin light chain repeat [IPR015792]", "LDLR class B repeat [IPR000033]", "Leucine rich repeat 4 [IPR025875]", "Leucine-rich repeat [IPR001611]", "Leucine-rich repeat, cysteine-containing subtype [IPR006553]", "Leucine-rich repeat, typical subtype [IPR003591]", "Low-density lipoprotein (LDL) receptor class A repeat [IPR002172]", "Mbt repeat [IPR004092]", "Microtubule associated protein, tubulin-binding repeat [IPR001084]", "Mitochondrial substrate/solute carrier [IPR018108]", "NHL repeat [IPR001258]", "Nebulin repeat [IPR000900]", "Neuraxin/MAP1B repeat [IPR000102]", "P120R repeat [IPR012586]", "PBS lyase HEAT-like repeat [IPR004155]", "PFTB repeat [IPR001330]", "Paired amphipathic helix [IPR003822]", "Parallel beta-helix repeat [IPR006626]", "Pentatricopeptide repeat [IPR002885]", "Plectin repeat [IPR001101]", "Plexin repeat [IPR002165]", "Proteasome/cyclosome repeat [IPR002015]", "Protein of unknown function DM15 [IPR006607]", "Protein prenyltransferase, alpha subunit [IPR002088]", "Proteinase inhibitor I27, calpastatin [IPR001259]", "Pumilio RNA-binding repeat [IPR001313]", "Putative TPR-like repeat [IPR031545]", "Pyrrolo-quinoline quinone repeat [IPR002372]", "RNA helicase p68 repeat [IPR012587]", "RNA polymerase II, heptapeptide repeat, eukaryotic [IPR000684]", "Regulator of chromosome condensation, RCC1 [IPR000408]", "Sel1-like repeat [IPR006597]", "Spectrin repeat [IPR002017]", "Spectrin/alpha-actinin [IPR018159]", "Tetratricopeptide repeat 1 [IPR001440]", "Tetratricopeptide repeat 2 [IPR013105]", "Tetratricopeptide repeat [IPR019734]", "Vesicle tethering protein p115, armadillo tether-repeat [IPR041209]", "WD40 repeat [IPR001680]", "Wolframin, Sel1-like repeat [IPR045458]", "Zinc finger, C2H2C-type [IPR002515]"], "available_proteins": ["AAAS", "ACTN1", "ACTN4", "AIP", "ANAPC5", "ANAPC7", "ANK3", "ANKFY1", "ANKHD1", "ANKRD17", "ANP32A", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA4", "ANXA6", "ANXA7", "AP1B1", "AP2B1", "ARMC1", "ARMC6", "ARMCX3", "ARPC1A", "ARVCF", "ASB6", "ASPH", "BARD1", "BIRC6", "BOP1", "BUB3", "CAST", "CDC16", "CDC23", "CDC27", "CEP72", "CHAF1B", "CKAP5", "CLASP1", "CLPB", "CLTC", "CNN2", "CNN3", "COA7", "COLEC12", "COPA", "COPB2", "CORO1B", "CORO1C", "CORO7", "CRNKL1", "CSTF1", "CSTF3", "CTNNB1", "CTNND1", "CTR9", "CTTN", "DCAF13", "DCAF7", "DCAF8", "DDX5", "DNAAF5", "DNAJC3", "DNAJC7", "DOHH", "DSP", "DST", "DYNC1I2", "EDC4", "EIF2B5", "EIF3I", "ELP2", "EMC1", "EMC2", "EML4", "EPPK1", "ERBIN", "FIS1", "FKBP4", "FKBP5", "FKBP8", "FLII", "FLNA", "FLNB", "FLNC", "FNTA", "FNTB", "GCN1", "GEMIN5", "GLG1", "GLS", "GRWD1", "GTF2I", "GTF3C2", "GTF3C3", "HCFC1", "HECTD1", "HIRA", "HTT", "HUWE1", "IFIT5", "IGF2R", "ILK", "INTS4", "IPO4", "IPO5", "JUP", "KAT7", "KDELC2", "KDM2A", "KIAA1468", "KIDINS220", "KLC1", "KLC4", "KLHL11", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNA6", "KPNB1", "LARP1", "LASP1", "LDLR", "LLGL1", "LRBA", "LRP1", "LRPPRC", "LRRC1", "LRRC40", "LRRC47", "LRRC57", "LRRC59", "LRRC8C", "LRSAM1", "LRWD1", "MACF1", "MAP1B", "MAP4", "MAU2", "MKI67", "MKLN1", "MPHOSPH8", "MRPS27", "MTCH1", "MTCH2", "MTPN", "MYCBP2", "NAA15", "NASP", "NEDD1", "NEK9", "NFKBIL1", "NHLRC2", "NIPBL", "NISCH", "NLE1", "NLRX1", "NOL10", "NOP2", "NOP9", "NOTCH2", "NUP214", "NUP37", "NUP43", "NXF1", "OGT", "OSBPL1A", "OSTF1", "P4HA1", "P4HA2", "PAFAH1B1", "PAK1IP1", "PDCD11", "PHIP", "PIK3R4", "PLAA", "PLEC", "PLRG1", "PLXNB2", "POLR2A", "PPID", "PPP1R7", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP4R1", "PPP5C", "PPWD1", "PREB", "PRKCSH", "PRMT9", "PRPF19", "PRPF4", "PRPF6", "PSMD1", "PSMD10", "PSMD2", "PTCD1", "PTCD3", "PUM3", "PWP1", "PWP2", "RABEPK", "RABGGTA", "RACK1", "RAE1", "RAI14", "RANBP2", "RANBP6", "RANGAP1", "RAP1GDS1", "RBBP4", "RBBP5", "RBBP7", "RCC1", "RCC2", "RPAP3", "RPTOR", "RRP9", "RSU1", "SART3", "SCML2", "SCRIB", "SEC31A", "SEH1L", "SEL1L", "SGTA", "SHCBP1", "SIN3A", "SKP2", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A16", "SLC25A17", "SLC25A19", "SLC25A20", "SLC25A21", "SLC25A24", "SLC25A25", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A33", "SLC25A4", "SLC25A44", "SLC25A5", "SLC25A6", "SLIT2", "SMU1", "SNRNP40", "SNRPA1", "SPTAN1", "SPTBN1", "SRP72", "STIP1", "STRAP", "STRN", "STUB1", "SUGT1", "SYNE1", "SYNE2", "TAGLN2", "TBL1XR1", "TBL2", "TBL3", "TEX10", "TGFBRAP1", "THOC3", "THOC6", "TLE3", "TMTC3", "TOMM34", "TOMM70", "TP53BP2", "TPBG", "TRIO", "TTC1", 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sha256:a93f0a755a3973b5323991dfec7d2e5b346ec1194a4bf7a0b889dd49ebc6de74 +size 376426 diff --git a/msigdb_gobp/df_merge.tsv b/msigdb_gobp/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..d23419fe7103e7a4c045983c431d8b495911727e --- /dev/null +++ b/msigdb_gobp/df_merge.tsv @@ -0,0 +1,234 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Mitochondrial transport 43 84 4.521848182875553 6.130202176546362e-06 26.76456310679612 83.42233009708738 1.9353944346565397 0.260698067067068 11.29934298946582 6.8259418360610375 1.9296757414965091 0.3685496297416806 1.2698045263993412e-16 0.0012471197288945 3.3947960014797515e-05 6.28992981582401e-10 2.860659714554489e-18 +Mitochondrial membrane organization 29 48 4.252840787888164 2.1107564940336943e-05 16.983009708737864 46.91019417475728 1.283632855732258 0.3380738792929293 7.413069190635445 4.027718639381892 1.6948461264793506 0.367302285357348 5.6579212944522645e-16 0.0108990791164893 0.0003120858048586 1.0445583939359311e-10 4.6525538867877e-15 +Membrane lipid metabolic process 21 40 4.090537082787961 4.303753887313633e-05 15.813106796116504 37.71116504854369 1.423850539998867 0.1808469841706369 6.252884620395072 4.742042041181393 2.289538519382486 0.2724480316274368 2.5773385949062723e-09 0.0197758267942588 0.0001498589333904 1.7678621856310766e-07 5.8196789450259134e-08 +Sphingolipid metabolic process 16 30 4.0025259849532855 6.26697823002953e-05 12.631067961165048 29.174757281553397 1.3566630100256978 0.1614907042591146 4.986857078326301 3.461093559903884 2.232073980338918 0.2503191978902473 3.649713567461242e-08 0.0102936075696032 3.158896646363367e-05 3.631499411723066e-07 4.791423482766161e-07 +Protein localization to mitochondrion 27 58 3.976325239464836 6.998838933580664e-05 18.37621359223301 58.6747572815534 1.743973973786015 0.2835887708870952 7.329731795051445 5.553888141183353 1.6030721833013164 0.3628376459321563 6.734977217171385e-12 0.0149620345130709 0.0005873272870129 2.908238193584641e-07 1.247915348586023e-13 +Oxidative phosphorylation 28 64 3.8918286828425512 9.94914894925092e-05 18.140776699029125 60.61893203883495 0.8137621380364766 0.3661293054253088 7.750013302753429 5.582386553809936 1.7413544544034578 0.3762713520958283 2.186069729108973e-09 1.4145097132979976e-06 1.635920485548201e-08 9.719570353971262e-07 3.6453772811509406e-10 +Anion transport 40 75 3.868086419767898 0.0001096927919002 26.953883495145632 69.53155339805825 1.854216838065017 0.2425457725148559 12.138973160217668 8.434296289414672 2.014686633079497 0.3448588040224388 9.793525253249837e-13 0.015300158159756 0.0006627325516806 6.98846930618967e-08 5.693698913795749e-12 +Mitochondrial transmembrane transport 35 51 3.7960827124696297 0.0001470004706989 19.070388349514563 50.63834951456311 1.9310146760091371 0.188342667216329 9.760351579527285 3.939196260509299 1.9786128158557912 0.3017981993827387 1.3174016645895856e-10 0.0007162824744306 1.6342529313586228e-05 0.000199462708587 1.2634828799203576e-14 +Inner mitochondrial membrane organization 14 22 3.6713658272524863 0.0002412577225416 9.985436893203884 20.800970873786408 1.138268089020681 0.2873707765098114 4.6289277788641146 2.4012939531921327 1.609232985153232 0.3229583948801056 4.794485604900434e-12 0.1635258499471353 0.048990890514732 1.6510644959116593e-07 5.547005144081462e-11 +Membrane lipid biosynthetic process 11 25 3.660242609478052 0.0002519765565107 8.866504854368932 23.050970873786408 1.3229385051208649 0.2431293012321725 4.229937732502716 3.4850337476777224 1.635527795490498 0.2996124846932806 2.5297134484405967e-05 1.0 0.0079219249747297 3.982217433367724e-06 0.000146373457931 +Electron transport chain 30 69 3.610396029231727 0.0003057298379685 19.550970873786408 67.77184466019418 0.3712062453977176 0.4872800905659868 8.486701420407794 5.37626783377928 1.3790913022045077 0.3735693075609537 7.963251683028042e-08 0.0036241696225553 3.777954081035598e-05 1.722582734314545e-05 7.149111845568422e-10 +Sphingolipid biosynthetic process 9 17 3.586716095741484 0.000334868568306 6.543689320388349 16.33252427184466 1.3108583596388097 0.2293036031089034 3.2058099533310203 2.4273143169149307 1.5209865792019848 0.2861850290041513 0.0001222984688709 1.0 0.0024373211620913 1.0496856898956417e-05 0.0004875982127202 +Protein insertion into membrane 13 24 3.527609988745598 0.0004193295062924 9.861650485436892 27.67718446601942 1.4180388387951812 0.2751856944202687 4.426616888970974 3.3195747527036987 1.508549988584809 0.3318307488597651 9.541059095863784e-09 0.2183067054048652 0.0128487417044244 3.0068110579927382e-06 8.28667164925179e-08 +Cellular ion homeostasis 46 89 3.496106241211512 0.0004721006923247 24.48543689320388 87.34708737864078 0.921352068115914 0.4223079442129951 9.212290310790763 8.933596252465952 1.5207794649628892 0.4002972861975121 2.2925103432131005e-07 0.379151373575087 0.2676537229472664 0.000941791183602 1.1037681496444173e-06 +Mitochondrial respiratory chain complex assembly 20 40 3.4807197987859912 0.0005000683331637 14.427184466019416 38.300970873786405 1.6683402305651691 0.229838901803248 5.648441561419256 5.588363345618 1.6629328950455762 0.3088219725228932 1.2821613548401557e-07 4.395927526276222e-06 1.4258415820678248e-08 1.1116401880288308e-05 9.480959994040974e-09 +Metal ion homeostasis 44 81 3.4744464229171808 0.0005119085814209 22.37864077669903 79.5 0.7762327689006491 0.4501210966631583 8.485414676383348 8.298876985671072 1.3957415688189287 0.3857448193070677 9.59168959588e-06 0.3617750709606537 0.2465206288516762 0.0113256212906844 2.9437014461185297e-05 +Ceramide metabolic process 10 20 3.4686071750169294 0.0005231638065135 8.191747572815533 19.060679611650485 1.0632949889077032 0.1865092544415649 3.2982239784478966 2.5917545738626013 1.8901201919357584 0.2494992632187684 1.5814690912742672e-05 0.2406936845278361 0.0002087091356766 6.09484178195159e-05 7.642967523267423e-05 +Lytic vacuole organization 13 25 3.4592131021747337 0.0005417560892091 8.677184466019417 23.79368932038835 1.067589638534915 0.1668002350701783 2.8744208086829883 3.077266940940983 2.0111064761459874 0.2496786569477077 4.396298125535372e-06 0.0335548880884004 0.0025924072114898 1.2092573128436562e-05 2.4886949241689784e-05 +Anion transmembrane transport 29 44 3.421781202583675 0.0006221235534624 18.02912621359223 42.29854368932039 1.9137296804814252 0.1915609440243116 8.771596162415214 5.032004157423188 1.8922368499585025 0.2935375719655638 2.2040955091592512e-08 0.1008495778431075 0.0007120475002836 4.58906761449932e-07 1.5676255324093423e-08 +Glycoprotein metabolic process 22 63 3.3942471690673943 0.0006881755107976 18.59223300970874 59.577669902912625 0.8707431654759812 0.409720724299967 7.543964208858723 9.989377193127202 1.488085349392555 0.3835029669336279 0.080059485814067 0.6674460421157596 0.3705363311771966 0.008659276852789 0.0834776210681562 +Protein targeting to mitochondrion 25 45 3.393688705584096 0.0006895803022188 14.980582524271844 46.067961165048544 1.7767024064550243 0.249920045184344 6.494927942714517 4.708517660750424 1.5433015545903224 0.3384144763122346 1.2291387541384657e-08 0.0085976741283889 0.0101118666995626 8.01264062434499e-06 1.1965326430489856e-10 +Endoplasmic reticulum organization 16 42 3.335246988456136 0.0008522366762844 14.91747572815534 43.67718446601942 1.1418424810127707 0.3725584991544436 6.208589840117394 4.768440325801463 1.6823827875834556 0.3705219831566139 7.50862401113111e-09 0.0057337308923017 0.0060698672163979 1.3126875107213773e-05 9.382205426599828e-08 +Establishment of protein localization to membrane 37 82 3.27360452582711 0.0010618510964781 23.133495145631063 87.3616504854369 1.231448880072231 0.4195243824117992 8.397245527204214 9.510228790351464 1.3947369206386535 0.4065372973031916 8.48161325783133e-07 0.07440901727418 0.013686897100908 8.534509218708185e-06 5.890159799706285e-06 +Protein transmembrane transport 14 23 3.23103928468617 0.0012334098644848 8.992718446601941 25.191747572815533 1.6893060623430327 0.189108476986505 4.473486660459625 2.7693940759543416 1.4682653164365471 0.2783169275392022 0.0012871525254375 0.0266825716175236 0.0919415891551245 0.3670688568616856 3.764908963105785e-05 +Cellular monovalent inorganic cation homeostasis 14 24 3.2073887275031527 0.0013394586681332 8.191747572815533 25.12378640776699 1.1978511848260835 0.2636491484517694 3.558748260132903 2.9783551257949803 1.4212259473978417 0.3021468238591936 5.273634836180541e-06 0.2552681350600493 0.4461675288226883 0.0006279861154086 5.478593541938059e-06 +Monovalent inorganic cation homeostasis 19 27 3.201812446107707 0.0013656588306369 9.014563106796116 27.87378640776699 1.1567920478867002 0.2845186374336156 4.051822262152646 3.607380814764068 1.4117439861533438 0.3149022278800241 6.837255432202012e-06 0.297366720714231 0.5071521873221705 0.0018365459096632 8.850050427314066e-06 +Vacuole organization 22 52 3.2013122971828243 0.0013680317330146 14.220873786407768 51.74514563106796 0.8524122478550634 0.3147425083910056 5.370022076358251 7.439112114793103 1.7567175511320523 0.3563110134355993 0.0005936842481211 0.1706177828799348 0.016676938082001 0.0013112629680253 0.0005087864126035 +Establishment of protein localization to mitochondrial membrane 9 16 3.1741408825612685 0.0015028072840064 5.572815533980583 16.524271844660195 1.1986544459127668 0.291784793504827 2.8501471321161915 2.5441524813639957 1.2232399066733852 0.3232066755573589 5.311894058016222e-08 0.1221118561195742 0.0021303683071518 2.56899960600128e-06 2.6557460223247744e-07 +Cellular transition metal ion homeostasis 11 22 3.164529931323225 0.0015533368423219 5.893203883495145 20.42233009708738 0.9608801516152976 0.3243056832171095 2.800529150274697 2.6932649561537056 1.130076157725316 0.3011842711337114 1.0512506719218531e-05 0.2695684389372801 0.1290920553826253 0.0200399882581909 5.741587504110391e-05 +Organic acid transmembrane transport 19 29 3.157496821260297 0.0015912997163594 12.37621359223301 29.983009708737864 1.9038035525846064 0.1759244630123113 6.520447095353999 3.550222565141749 1.416714921004232 0.2641413901650407 0.0014932354789087 0.3208381238265493 0.1793408912067547 0.0031061282245647 0.0004431313439272 +Liposaccharide metabolic process 9 20 3.142670318405304 0.0016741428379321 7.393203883495145 16.839805825242717 0.7162233803449398 0.1804705798886219 2.8837934205508033 2.921890590438037 1.8930166841377585 0.2403675114219934 0.0001053468440953 0.2443632781182481 0.0181443698350236 0.0026306375243077 0.0004229506315236 +Organic anion transport 32 51 3.1242868109202013 0.0017823662881422 18.575242718446603 46.57281553398058 1.6158560948583975 0.2692356013040078 9.46386426798458 5.9518324529926545 1.7470285445738305 0.3371920110610632 3.643233385707536e-07 0.1520007577137938 0.1608702453512187 0.0001843426293797 3.990985325408788e-07 +Cytochrome complex assembly 8 13 3.097296645048201 0.00195294336534 5.339805825242719 11.616504854368932 1.5489281771301031 0.1834582376033618 2.45860248431673 2.439266047793512 1.3189185418401956 0.2620853228235733 6.191534775953672e-06 0.0005621116792476 1.6515245584177265e-05 0.0001415457384854 2.4597593044142757e-05 +Transition metal ion homeostasis 12 25 3.081237670193903 0.0020614203271127 6.640776699029126 24.57281553398058 0.9239194315613378 0.3015424973151205 2.934079531592402 2.8081087224394015 1.2471169312381896 0.2974369333820005 1.9249421053179456e-05 0.0564048148733258 0.0415809882988902 0.0126135475433129 0.0001129876503173 +Respiratory electron transport chain 25 52 3.0802747583114014 0.0020680971446274 15.4126213592233 50.33495145631068 0.497076868891423 0.4388579749555677 7.129498131980449 4.223655269147207 1.4894225458303931 0.3736358875877055 2.880208708612896e-07 0.0011305823171669 3.611186852814194e-06 3.0881789758633883e-06 4.4091757555991655e-09 +Mitochondrion organization 86 191 3.067604522864546 0.0021578198229368 56.45873786407767 188.26941747572815 1.5905300936136977 0.4100157441778524 20.15716756472138 18.40319032732565 2.034523716094369 0.4327537677377048 1.1351331102709615e-24 6.850602503691581e-07 9.487330678408251e-11 7.936928738011708e-18 5.7125183906157505e-27 +Membrane lipid catabolic process 7 11 3.0290526841191223 0.0024532189776811 5.854368932038835 11.361650485436892 0.500872843713425 0.1363587272813367 1.9603237645724247 0.9867004907377388 2.113024793917032 0.2289617793743788 5.981482419895312e-07 0.0040679264544396 1.0236679094826864e-06 9.045491853019026e-05 2.1902966903943494e-06 +Ceramide biosynthetic process 6 11 3.011398691721892 0.0026004716166931 4.033980582524272 10.24757281553398 1.048715387316577 0.2344614502118888 2.237979905601341 2.0281678881596505 1.4071730245015133 0.2685344998940062 0.0004526864338107 1.0 0.0045096021611559 0.000167417985794 0.0012514150662819 +Glycoprotein biosynthetic process 18 55 2.991215284090563 0.0027786952070223 16.72087378640777 51.87378640776699 1.042113998842759 0.381483262234126 6.756316800759528 8.908847583990125 1.5232206853916193 0.3819786061588057 0.0896433967232995 0.603038217660401 0.5483590128255319 0.0168074693834496 0.0785745353842448 +Regulation of ph 10 19 2.979816827140215 0.0028842079462358 6.890776699029126 20.859223300970875 1.2151699598837196 0.2373503364294603 2.930458126920059 2.7746402510870145 1.4154672965603718 0.2873526492076106 3.977194163498478e-05 0.2220822570468345 0.3955810682553247 0.0014919193154812 3.11780669585079e-05 +Regulation of cellular ph 10 19 2.979816827140215 0.0028842079462358 6.885922330097087 20.844660194174757 1.215766922704761 0.2375185297794358 2.9319293283093293 2.765976649626597 1.4143296516981956 0.2875299337708636 2.305785191695632e-05 0.2107016729382093 0.3777229935777695 0.0010882828125207 1.7163900968398735e-05 +Protein targeting 51 111 2.9616941479764005 0.0030595153582326 30.48543689320388 111.54126213592232 1.595466660966077 0.3336055854889273 10.683999539888966 11.70327920021055 1.673091584234216 0.3988264387816677 2.3959802517177223e-09 0.0068519784881021 0.0028162377069727 2.6895139226227917e-06 3.0572542494108683e-10 +Ion homeostasis 54 107 2.948294522642488 0.0031953248021601 28.021844660194176 105.69174757281552 0.8349951537384392 0.4299135801564597 10.40966729997928 11.411952082971936 1.4722934854811005 0.3963893325418664 2.349542091582559e-07 0.2134389652995229 0.2146477732815008 0.0028194701470885 6.729082469740695e-07 +Ph reduction 7 12 2.881005717677485 0.0039640844934205 4.422330097087379 12.509708737864075 1.1966830084586066 0.1930048880851129 1.91475781321527 1.7851607614701208 1.4167744165903868 0.2497649393583847 1.1055565914631605e-05 0.1263420182810564 0.2372212797486779 4.476197901851534e-05 3.828861199610836e-05 +Proton transmembrane transport 19 43 2.879851039025927 0.0039786310250875 14.28640776699029 43.01699029126213 0.7821394801431882 0.3918912894345224 6.076814900000799 3.1076483585332 1.5710697941383835 0.3739424994204808 2.0983465312209097e-07 0.0748187401998431 0.0020689855180955 8.5039555642666e-05 2.294210575189864e-06 +Endoplasmic reticulum tubular network organization 5 11 2.856355429495636 0.0042853511300282 4.150485436893204 10.555825242718448 0.8961707031484618 0.3171343629503343 2.1669796342432037 1.8339543060404635 1.2935176897309475 0.3199619326088047 3.804209199370071e-05 0.0029386578360865 0.0113213926532688 3.830880641039723e-05 9.937036022358197e-05 +Nadh dehydrogenase complex assembly 12 28 2.840969444134701 0.0044976621590491 9.266990291262136 26.96359223300971 1.1245271541492263 0.3013677937017552 4.122702675359976 4.029157649894909 1.4460543016521823 0.3224564676521605 9.042665829331118e-05 0.0025436512836883 1.650863864145163e-05 0.0004129808075874 1.4366492032750328e-05 +Organophosphate ester transport 16 30 2.8334813652548334 0.0046043992451607 10.29126213592233 27.364077669902912 1.4948680330369015 0.1889391065154625 4.84293313185659 4.31957284765524 1.6451867819665518 0.2532208690981375 3.218625029946423e-06 0.0551599902794207 0.0402942577421927 0.0028924350901622 2.278200239747344e-05 +Intracellular protein transmembrane transport 11 20 2.8311999031968096 0.0046373727780535 7.233009708737864 21.9004854368932 1.450039081018812 0.2247265328975946 3.8281123729210935 2.4627910122818513 1.3220665029303609 0.2876555154826584 0.0356515059560401 0.1952735388158895 0.3530974878629287 0.6676078298658026 0.0012835617051806 +Inorganic ion transmembrane transport 49 114 2.7999219551979246 0.0051114963155649 32.300970873786405 111.99514563106796 0.9881513097876132 0.4268253140664947 13.185263141323642 11.586314982845243 1.7161030277526947 0.4113555760685328 1.3753629660235714e-06 0.4929961271860759 0.0055239588642423 2.6554390800739168e-05 9.267275841682528e-06 +Carbohydrate derivative transport 15 20 2.796584745754768 0.0051645864516993 7.924757281553398 17.024271844660195 1.3665639952580566 0.1869571280171947 4.210097511648942 2.624454303682939 1.5541767319140831 0.2467993156006303 2.1357855373530726e-09 0.1991580424676108 0.3593428278464597 0.0001047370599813 1.9245529128315722e-08 +Atp synthesis coupled electron transport 19 40 2.7920969316241284 0.0052367665983559 11.567961165048544 37.61407766990291 0.6403585631460136 0.4181082416574377 5.189865284224125 3.9859091462453993 1.417482213086961 0.3703097362636519 2.74909068157664e-06 0.0005171916005075 9.239395686414916e-06 1.6588642191944233e-05 7.882177421735883e-07 +Metal ion export 8 11 2.7849903470177666 0.0053529316611118 3.779126213592233 8.553398058252426 0.5059205316086877 0.4155863674545267 2.112664358767855 1.499049247815051 1.150738830143596 0.3315496346975708 0.0094903075706385 1.0 0.0170518298819148 0.0901924811619011 0.017002584405276 +Glycosphingolipid metabolic process 6 11 2.7632179908200856 0.0057234527263365 4.764563106796117 9.184466019417476 0.4485135251287195 0.1553285492394019 1.7516723087054535 1.7320372023153958 1.93068386398988 0.2217231968869004 0.000308637682475 0.1471951297158956 0.0038117145357013 0.0078094686864188 0.0008647189955035 +Regulation of membrane permeability 6 19 2.747507249281253 0.0060050181380142 4.347087378640777 18.645631067961165 0.1981071582870727 0.6054076942188011 3.2408820958737863 1.6665339124556926 0.7786435166038244 0.2968416300691248 0.0204396067821095 0.225839943305071 0.4014202890149608 0.135543868878084 0.0423415641222214 +Cartilage development 7 16 2.7395484785776727 0.0061523640751757 3.932038834951456 14.283980582524272 0.7074320636322524 0.4287139668901396 2.125947582774665 2.5119975572795252 0.8798730191625526 0.3016172221818579 0.0785720931975648 1.0 0.5863803216648996 0.0687674325027371 0.0740259683450741 +Divalent inorganic cation homeostasis 27 55 2.726577910910391 0.0063994842678596 15.361650485436892 54.019417475728154 0.5485088157809707 0.5170537035394376 6.04857242197355 6.215359275440269 1.1779017300469032 0.3778837346959196 0.0080595939591999 1.0 0.528007824876168 0.0754653182683026 0.0076758096099639 +Regulation of hormone levels 28 60 2.6871608189559786 0.0072062248140407 15.682038834951456 62.25485436893204 0.7754141622249116 0.4638741971732045 6.630568201753413 6.49574922456989 1.111399769110166 0.3798141702267368 0.0328103577460734 1.0 0.1559477440516821 0.1544336478587294 0.0185295645038797 +Steroid metabolic process 22 70 2.670387087079192 0.0075763848579812 17.82766990291262 66.9247572815534 0.9974586731388552 0.3270410156332073 6.090491666967852 5.93996409793671 1.7133199907504504 0.3720334828404655 5.374363653317841e-06 0.5310682828592934 0.0038567461314132 2.364847290569613e-05 6.00013087880394e-06 +Regulation of blood pressure 10 15 2.653103752663116 0.0079755351539099 5.762135922330097 17.737864077669904 1.3077123393993415 0.1882731913471478 2.2751770017499977 2.3871059987956724 1.372929386780725 0.2480453688154592 0.0005265614813032 0.2443632781182481 0.107004894081217 0.1641182363781922 0.0017715044959542 +Cation transmembrane transport 52 121 2.646652276477454 0.0081292895646694 33.43446601941748 118.4004854368932 1.1701058025505957 0.4085228823574113 14.425169362008605 12.553856783980793 1.6663185381795875 0.4066910074955585 5.205919080340659e-07 0.5413773680429788 0.0030970494494587 0.0002767008582826 4.893066789595246e-06 +Porphyrin containing compound metabolic process 7 17 2.643791283368618 0.0081983191816854 4.91747572815534 16.531553398058254 1.0269348271542438 0.279733852070357 2.276512713100022 2.089380108414912 1.2578863722796805 0.2914421038569487 6.507365754392104e-05 0.0121686135974036 0.0443091130960601 0.0014099836558107 0.0002147363626889 +Connective tissue development 8 27 2.627943689808085 0.0085902734319758 6.759708737864078 24.91747572815534 0.897701915164713 0.400129048313066 2.7453452066208146 3.8608044632925673 0.8993390896039578 0.3237981500894625 0.0789222176398767 0.462328834210194 0.3491903780040699 0.0352346724005287 0.0928229237074456 +Cristae formation 7 9 2.62431474264045 0.0086823510965861 4.740291262135922 8.861650485436893 0.8982766043222677 0.3392698633906088 2.216011442046921 0.6593503673812457 1.2485531022675598 0.3418736408093433 4.870764737184358e-07 1.0 0.1265462710440741 0.0002735626391213 1.5533184688236115e-06 +Bone morphogenesis 4 10 2.6145256001458224 0.0089351464230491 2.3737864077669903 7.519417475728155 0.7918915806069479 0.3290665752918499 1.3241931901591228 1.4011478132752644 1.0549507058478411 0.2731796281548322 0.0356515059560401 1.0 0.3530974878629287 0.0940672040532474 0.0655768501043339 +Negative regulation of protein secretion 4 10 2.610596269455617 0.0090384528363558 2.366504854368932 8.674757281553399 0.7907680055493084 0.3977556251115637 1.568545308844716 1.6283423250335054 0.8427072898625886 0.2857999704117771 0.0068337419321114 1.0 0.0334071197556988 0.0055331858379351 0.0137665493817408 +Positive regulation of macroautophagy 7 19 2.600087321757918 0.0093200041392031 5.058252427184466 20.34223300970874 0.7197293510270528 0.4154159089925248 2.5734840677494253 3.836065802213299 1.0387053871978371 0.3265560923975395 0.0108376814481001 0.2516504230112798 0.0025924072114898 0.0564393829037643 0.0254457366029634 +Respiratory chain complex iv assembly 5 7 2.5980847635299757 0.0093745349695755 2.7475728155339807 6.451456310679611 1.036831430168084 0.2562354664331627 1.605321530277248 1.669274831081891 1.262804896468415 0.2848709091577191 0.0004120234665719 0.1135912525516411 0.0016986126979642 0.0028063338575205 0.0010205277760807 +Tetrapyrrole metabolic process 7 19 2.5957101943911267 0.0094395646003113 5.652912621359223 19.283980582524272 1.0342508202848784 0.290677507336007 2.6828141040028877 2.549402305664568 1.2308389507353266 0.2976223887279709 0.000354880510298 0.0188245552589776 0.0666692325567911 0.0039562767661884 0.00110124435718 +Regulation of mitochondrion organization 15 45 2.5759667339533445 0.0099960262867311 12.08980582524272 45.08252427184466 0.8217268052205459 0.4563186211764868 4.409741308614158 5.146210353910189 1.120993905462196 0.3778427085178187 1.055035487139566e-05 1.0 0.091109134162985 7.272708756645544e-05 8.491645604992822e-05 +Regulation of mitochondrial membrane permeability 6 15 2.5759280505033733 0.0099971446519837 3.966019417475728 14.96359223300971 0.2402793183028587 0.524743519159013 2.950861430851842 1.4816465220322803 0.9084604001489732 0.298358218544212 0.0095183457400119 0.1952735388158895 0.3530974878629287 0.0940672040532474 0.020723717832043 +Regulation of release of cytochrome c from mitochondria 5 9 2.565837041368826 0.0102927171173083 3.6310679611650487 10.805825242718448 0.7924389389582319 0.4006886058463786 1.815469081442188 1.3603843861930187 0.9712392086725492 0.3199873643457663 0.0013915714203141 1.0 0.0354914601129098 0.0062346640440273 0.0033138804057902 +Endoplasmic reticulum membrane organization 6 9 2.54955717049442 0.0107859824895439 3.5679611650485437 8.12621359223301 0.656874598832497 0.271683145803182 1.813579499342004 1.2879547393790816 1.532817064292788 0.2945772195616556 2.523982848286904e-07 0.0017062060788896 0.0066572828402184 8.624555272386569e-06 8.104989222609044e-07 +Aerobic respiration 31 91 2.540772413155525 0.0110607891315928 23.075242718446603 86.43446601941747 0.4685851027775424 0.4381258038241513 10.546552774557412 6.275478278783705 1.570513830163352 0.3792860784147517 2.6735647733912483e-08 9.73834781515068e-06 3.3741211379120163e-09 1.3676184949449754e-06 2.303851758671074e-09 +Vacuolar acidification 5 8 2.527418502020762 0.0114904488860321 3.4757281553398056 8.922330097087379 1.27407749822917 0.1611429668415415 1.4148632661931722 1.303016071016461 1.4195929612668792 0.2212670077717619 5.5105284909181895e-05 0.083126337411673 0.1596960736798767 5.200397996359343e-05 0.0001429815632908 +Ion transmembrane transport 76 158 2.5239851167089853 0.0116032841032058 47.09466019417476 154.11893203883494 1.555073205784263 0.3634279635891347 19.61122797656 15.97124025754773 1.9676287128633565 0.411597796705808 1.052928375585228e-12 0.067145446295508 6.49370644714716e-06 3.874117728369975e-09 9.838638756268936e-12 +Chloride transport 8 13 2.520366288464528 0.0117232769341109 4.33252427184466 12.12621359223301 1.0302584084066435 0.2341882174183942 2.3624510960969567 2.26059366569241 1.2797232968088257 0.2563105728143979 0.000308637682475 0.1471951297158956 0.0398064357050217 0.0078094686864188 0.0008647189955035 +Amino acid transmembrane transport 8 13 2.510049667903119 0.0120714181537981 6.213592233009709 14.228155339805824 0.7890307267204019 0.3318923540291705 3.493823914060917 1.9561661273054285 1.3497309258640615 0.3227865040448734 0.0419220169184899 1.0 0.3655284832956332 0.0262238710799836 0.0252009464097718 +Copper ion homeostasis 5 7 2.5091296294035 0.0121029060822452 1.6771844660194175 4.669902912621359 0.4484316971142749 0.3058603694529516 1.2128614304476144 1.4202990900289796 1.3716690980071935 0.284002300922153 2.5490694344068226e-05 1.0 0.1432798584585485 0.3236592382947187 6.703246650942136e-05 +Cellular copper ion homeostasis 5 7 2.5091296294035 0.0121029060822452 1.633495145631068 4.138349514563107 0.8027486766067657 0.3358654651123308 1.1881879887367894 1.18353805365164 1.0950331419070014 0.2903029711159642 6.066821636393078e-06 1.0 0.1180585699575878 0.2721697661507766 1.6279070379868977e-05 +Inorganic anion transport 17 28 2.50297223949478 0.0123155203546529 9.900485436893204 25.351941747572816 1.3590123122148194 0.2025490755989976 4.608697956226863 4.352203003870329 1.5972877171217004 0.2769639658120273 5.813204215127672e-07 0.0432831882721129 0.0005115527825537 3.837942278655153e-05 7.951632818730826e-07 +Transmembrane transport 110 216 2.4973266110455565 0.0125133643553896 67.45631067961165 211.1359223300971 1.8122664376950308 0.3598356673827246 27.267027885156203 22.354947126810902 2.251277763144546 0.4188333713481413 1.5564605921468525e-17 0.0112371844547471 2.631697407787137e-06 2.920846711645662e-09 6.157800976962851e-19 +Import across plasma membrane 13 20 2.493200527009666 0.0126597326887658 6.601941747572815 18.643203883495147 0.5666543433877399 0.4743790616320767 3.944616106748078 3.664494750162088 1.0498181035479843 0.3397186310535848 0.3775475210318679 1.0 0.5213291194813008 0.2776494479137136 0.5077964068323771 +Lipoprotein metabolic process 8 19 2.482454780623312 0.0130480627560898 5.504854368932039 19.114077669902912 1.0723975558987071 0.2794846862458811 2.648039342123219 3.7213756556771336 1.2556798055308762 0.2951644225033464 0.0587088131761539 0.3371313972628795 0.0483217377147592 0.0543296939149059 0.1181853417157704 +Antigen processing and presentation 10 24 2.478581609454731 0.0131905931808766 6.201456310679611 22.17718446601942 0.8231471183465873 0.4220086818460768 2.970845032857872 3.056135613532617 0.9682333159777928 0.3245513416930483 0.0826815834420135 1.0 0.4242240140575919 0.7524126639072135 0.005918859062877 +Protein transmembrane import into intracellular organelle 7 11 2.4773098128038984 0.0132376938583926 4.951456310679611 13.45631067961165 1.503963012554726 0.1758225015375162 2.735521961789203 1.4944992929031071 1.2360761671845495 0.245991671368161 0.032595105977084 0.134742527043449 0.2518545844225215 0.5198923492291299 0.0004675519327548 +Glycerolipid biosynthetic process 27 51 2.4747675605481865 0.0133322914410134 13.466019417475728 44.71844660194175 0.9430872689732808 0.3767257192898063 6.88753698417372 8.249645447783736 1.3199493331746477 0.3584243730449019 0.0164593474709815 1.0 1.0 0.1480214415281834 0.006897889497246 +Mitochondrial fusion 12 16 2.4635306026464825 0.013757615047317 5.730582524271845 14.140776699029129 0.9082040747396848 0.3521825448687026 2.97444400458197 2.016819417247653 1.0465735301082626 0.3054031781597867 1.4726801524297762e-05 1.0 1.0 0.0005802452812718 5.837517180193655e-06 +Steroid biosynthetic process 22 47 2.460327442198849 0.0138810305578336 11.728155339805824 44.80825242718446 0.9874364787035632 0.3935759881445143 5.016369659264937 4.35272817633461 1.2862817592315925 0.3680333006848349 0.0001514815652118 0.3746890061856052 0.0665208936004256 0.0005389062786004 6.189616675557875e-05 +Organelle fusion 23 46 2.4583393476193955 0.0139581211356938 14.74514563106796 45.383495145631066 0.6448767361523368 0.5292766623385164 6.293825046556003 6.576179389035289 1.1045479661060835 0.3741954647136961 0.002743437544451 1.0 0.3068592732118059 0.0220782152653952 0.0040311107174636 +Chondrocyte differentiation 4 12 2.4523168163747604 0.014193962919919 2.6650485436893203 9.92233009708738 0.2607944337218785 0.5422880967404352 1.6748979819889611 1.9850867305810889 0.8369685556388278 0.2884880468615965 0.0826815834420135 1.0 1.0 0.0483010618227088 0.1419195504310158 +Protein insertion into mitochondrial inner membrane 3 5 2.448675635314071 0.0143382505748905 2.45873786407767 5.665048543689321 0.6692509200083531 0.3406754428009103 1.501050234026552 1.645659707056692 1.2686438529444872 0.3125184360343283 0.001050672309299 1.0 1.0 0.0025975272437437 0.0019884945269669 +Mitochondrial cytochrome c oxidase assembly 4 6 2.4375901529067945 0.0147855268909378 2.344660194174758 5.764563106796117 0.9954600272926416 0.2681565835601643 1.449018962088891 1.4364892997002987 1.2150903662861117 0.2820677765861404 0.0016518039309861 0.1006582454154426 0.0011613234829685 0.0152248647419399 0.0034992238505004 +Endoplasmic reticulum calcium ion homeostasis 6 9 2.435375720854489 0.0148763338881936 3.412621359223301 8.468446601941748 0.7163576234395546 0.3718536853795897 2.0059706805420334 1.5568434939403433 1.1166052913833018 0.3156746531372333 0.0016518039309861 1.0 1.0 0.0017174581383874 0.0034992238505004 +Ceramide catabolic process 4 6 2.425065932880369 0.0153056067476942 3.8592233009708736 6.531553398058253 0.1286784152295923 0.1423502941444668 1.429436503356119 0.7012295128365029 2.0219843992394857 0.2259194528389771 6.971717076711458e-05 0.0561990347849709 0.0001778916397324 0.0025975272437437 0.0001575214550341 +Lipid localization 20 77 2.422595534547217 0.0154100732908801 20.1504854368932 74.27912621359224 1.3966421040883936 0.3001252105784707 7.306180038477171 9.39465098860316 1.572418240819249 0.3627304234720817 0.0007242094979264 0.0895964033786971 0.0012667041047781 0.0027030048581013 0.0024767712567506 +Nucleotide transport 12 15 2.4092625555298257 0.0159847937516466 6.189320388349515 13.405339805825244 1.3859091987706234 0.2148450774807873 3.399469193898354 2.266957807297256 1.34942986946681 0.2785977875693559 3.470094493761131e-08 0.0068317681715133 0.0255840399150975 0.0003409473829516 1.74740243519954e-07 +Mitochondrial calcium ion homeostasis 10 13 2.4068099423181533 0.0160925422631059 4.62621359223301 10.509708737864075 0.2790428491871666 0.3774917598770124 2.1634860921400008 1.7383182679254283 1.294226020505384 0.3175561312397286 0.0094903075706385 1.0 0.1837383274168749 0.0901924811619011 0.0028145739091465 +Transition metal ion transport 6 13 2.405405813959056 0.0161545155530236 4.70873786407767 14.08980582524272 0.8861898222657586 0.2678437025860737 2.4756329698054333 2.718007722894407 1.3738160036140448 0.271065502827487 0.0099113183803482 0.2480154974279715 0.1100932826860655 0.053649406266927 0.0234193598976723 +Amino acid transport 12 20 2.404959352461632 0.016174264698481 7.771844660194175 19.75 0.8410032854505353 0.3449280742441291 4.117377746800764 3.003739578643708 1.287399790463736 0.3206698223659758 0.0221816270740355 1.0 0.4876012483283494 0.0849374332498421 0.0180976191812076 +Mammary gland development 6 23 2.400738107913019 0.0163620419563426 5.216019417475728 20.41747572815534 0.5512318000747981 0.5167791069166561 2.3942560065426757 2.728043047822029 0.8380822573448591 0.3178008321809467 0.0587088131761539 0.0627750690965546 0.0483217377147592 0.1492356701793886 0.1181853417157704 +Water homeostasis 3 9 2.398744174692152 0.0164514039194434 2.3009708737864076 8.754854368932039 0.3898668649661369 0.5164768351031709 1.4503762582219135 1.363747239113484 0.8444870119792014 0.2871771549776885 0.0259503462691174 1.0 0.0293903981750984 0.0042924995678 0.0446088038944012 +L alpha amino acid transmembrane transport 6 10 2.384639758631028 0.0170958529679783 4.480582524271845 10.533980582524272 0.7590361902351016 0.3223730555033793 2.606398335255894 1.1951807271273862 1.273814103695318 0.3116596719827348 0.0102974369955074 1.0 0.2732850813359189 0.0078094686864188 0.0045924061823516 +Regulation of macroautophagy 18 54 2.379246748324774 0.0173480590366368 12.53883495145631 54.54368932038835 0.6601926076755246 0.5184966676512008 5.17189441564166 7.149617002477752 0.982640144191414 0.3711017134042489 0.0032816960801128 0.4778436071549874 0.0018041561253073 0.0157806738818379 0.0021062495932256 +Sensory perception of light stimulus 7 16 2.376616485659085 0.017472243689584 5.009708737864078 15.96359223300971 0.918103407248628 0.3572194322029593 2.4583724414330383 3.147064390877318 0.9947617981182544 0.3055434177582076 0.0177565971756722 0.2731012734555347 0.1323300889211223 0.2130027955338551 0.0401410360295106 +Protein import into mitochondrial matrix 5 8 2.3726099776866016 0.0176629039420117 3.3276699029126213 9.03883495145631 1.4677455160780188 0.1396272549365287 1.9612536628062327 0.7162785445212654 1.2893924319512868 0.2212161399323651 0.021417379304658 0.0697581245313758 0.1349531130589082 0.3069124011154697 0.0005289198821125 +Mitochondrial genome maintenance 6 9 2.3725603794973584 0.0176652755845254 2.5970873786407767 9.099514563106796 0.4306784309108238 0.5191675610799616 1.8467476691551616 1.335584580667961 0.8583625990868251 0.3062673449054504 0.0001450821031219 0.0963063052639835 0.1837383274168749 0.0901924811619011 0.0003689915939861 +Sphingoid metabolic process 3 5 2.37096644806677 0.0177416415510611 2.337378640776699 5.174757281553398 0.8258730035764346 0.2192038420096116 1.196784089801513 0.5941001920342514 1.4738240163378542 0.2563928956394505 0.0004758293614935 1.0 0.0039135152062846 0.0014684283121974 0.0009118158302113 +Inorganic anion transmembrane transport 9 10 2.370758639972755 0.0177516190163924 3.4101941747572817 8.983009708737864 1.1245392058053427 0.2357455210082705 2.3748669786284156 1.7214248641786654 1.1968417731555627 0.2697184972505711 0.0291602574379564 1.0 0.2445730022705269 0.0048864602536943 0.0498364179528963 +Amyloid precursor protein metabolic process 8 20 2.368196097270039 0.0178750588299274 5.91747572815534 20.04368932038835 1.2306110398413417 0.2828388345239639 2.574706211328507 3.0661056512526157 1.0127867956133585 0.2841981221806073 0.0067752272248323 0.0285808600856777 0.0978881295505725 0.0102355224712358 0.0047453897441578 +Protein localization to vacuole 5 21 2.3642432374244624 0.0180669461820017 5.20873786407767 20.24757281553398 0.5437651170857908 0.3970016112497027 2.9079938968471533 3.678442701839641 1.178287503307516 0.309681546976434 0.0282228859794635 0.2406936845278361 0.0173242512102645 0.0483010618227088 0.0570529296125973 +Regulation of steroid biosynthetic process 6 10 2.3496900513514114 0.0187890494704443 3.186893203883495 10.259708737864075 0.6168896095149775 0.3174156062343823 1.783561142158544 1.373475469974866 1.265753415239616 0.2847701277650337 0.068236615852184 1.0 0.3076603852203092 0.6053596540060717 0.0093317531476842 +Phospholipid biosynthetic process 29 61 2.3330145497419035 0.0196473816922497 15.191747572815531 54.88834951456311 0.3601791313916425 0.5325104042072244 6.85810624136386 9.315774292776531 1.1122724170508866 0.3517335331311575 0.0133571659392074 1.0 1.0 0.1888024401065534 0.0062621105089096 +Aminoglycan metabolic process 8 17 2.330745336834317 0.0197667920419521 6.650485436893204 15.218446601941748 0.5538240398360251 0.1973407167351751 2.4739761552565955 2.4752855115427597 1.8355272359461776 0.2521795038965069 0.0128764277461169 0.2588687133858448 0.4515227909961177 0.0166327696461577 0.0298513421744587 +Cellular respiration 38 106 2.32797142488277 0.019913621049074 27.975728155339805 102.1019417475728 0.3887198796668061 0.4496840882999475 12.70690482749566 7.191843824002275 1.6294784865611704 0.3894421445164553 2.775307471787776e-09 2.9922625081161225e-05 2.919584113369751e-09 1.3829773173202722e-07 1.0435765121420284e-10 +L amino acid transport 7 11 2.3252388610080628 0.020059191456655 5.114077669902913 11.91504854368932 0.7755289387861473 0.3283794523692901 2.998235059113201 1.3256494094845783 1.3058948249973923 0.3189923022900864 0.0116776996200851 1.0 0.2802926639431586 0.0086864012748381 0.0053527619374205 +Adult behavior 5 16 2.323415463138731 0.0201568442126094 4.924757281553398 19.364077669902912 0.6031935344655648 0.4116465050786389 2.137657889318908 2.190772988063693 1.071812274679601 0.3090358289458393 0.0491033002504774 0.2695684389372801 0.0244837275894334 0.0200399882581909 0.0946135485635064 +Proteoglycan metabolic process 3 10 2.3206730956885893 0.0203044938371117 3.0558252427184467 7.347087378640777 0.90943742591388 0.2775323863615319 1.813993622553226 2.3052106999156825 1.19959130355936 0.2714444012698452 0.0976349109079508 0.187449079081247 0.3404254693467198 0.0195417527514502 0.1542690309953486 +Glycosylceramide metabolic process 3 5 2.313245352405996 0.0207091533592036 1.6019417475728157 3.6237864077669903 0.6319353949505291 0.2725232617281626 0.981279191145714 1.1370705133968653 1.4246462713481394 0.2720167900467778 0.0007236872631295 1.0 0.0047533286028597 0.001983278822638 0.0013781701696679 +Er nucleus signaling pathway 7 13 2.3131171845444047 0.0207161971443137 4.563106796116505 13.361650485436892 0.3617919622488442 0.4304556920046536 2.3428051517114805 1.3174649068389608 1.1974910326877934 0.3346175168774911 0.0030984377022794 1.0 1.0 0.0106277501006418 0.0014896299843671 +Regulation of oxidoreductase activity 11 16 2.3114189725447 0.0208097239930935 4.745145631067961 16.524271844660195 0.8435277245089666 0.3527293456818395 2.542951562396442 1.641953963820047 1.0033906386071183 0.2899852749738094 0.0222292440032413 1.0 0.4072036678679048 0.1411134338084059 0.0457670040656382 +Endoplasmic reticulum unfolded protein response 11 21 2.309712667182896 0.0209040670494533 5.922330097087379 20.817961165048544 0.3028076268112233 0.5117002472852509 2.747246884507101 1.9665572199818449 1.041467084382159 0.3322997623752832 0.0222292440032413 1.0 1.0 0.0408612650970917 0.0042301612836837 +Negative regulation of secretion 5 20 2.307350000848105 0.0210353161774219 4.148058252427185 18.021844660194176 0.8973427539161298 0.3984823243406039 2.1406652437798495 2.8560969523306214 0.8942114095598058 0.3123655158346225 0.0491033002504774 0.2695684389372801 0.0244837275894334 0.0200399882581909 0.0946135485635064 +Endoplasmic reticulum to golgi vesicle mediated transport 23 62 2.302768936816612 0.0212918471512488 17.32766990291262 65.39077669902913 0.808881464821498 0.4942452999677598 7.539018980743236 6.620812461410292 1.284359804176963 0.3933269611423161 0.000240727750752 0.002200987019757 0.0008183437155586 0.0018231981497059 0.0013160779369234 +Atp transport 6 7 2.296952196593863 0.0216214968810244 3.4805825242718447 6.233009708737864 0.5838786306840471 0.3211615036091749 1.83337760624298 0.8807971179633459 1.3636108978108328 0.3170401972517012 1.2286404123364386e-05 1.0 1.0 0.1973959389561772 2.8311070051942505e-05 +Dicarboxylic acid transport 9 16 2.2930676213982277 0.021844112143514 5.718446601941747 16.097087378640776 1.1205667041867788 0.2998586575349944 3.584398436287638 2.226340822602054 1.0973546365412417 0.2986830136605488 0.0067920673311003 0.1835089509173778 0.3339976348230559 0.0004698927732866 0.0037452233271246 +Protein localization to endoplasmic reticulum 14 33 2.2912830756145977 0.0219470468116009 9.50242718446602 34.50485436893204 0.9935384348474128 0.428255638055916 4.399083524593319 2.6617527855555916 1.1934894982037212 0.3717243536861919 0.0004612005893323 0.0305319028295214 0.1039407380726692 0.0483010618227088 0.0003655904724143 +Cellular homeostasis 62 145 2.275270050009316 0.0228897349362351 35.03155339805825 140.69660194174756 0.4666088113804902 0.5685618966047314 11.62423291193178 14.777892439656425 1.1736922314243927 0.3887657095146841 2.127585679967339e-07 0.3323602521916406 0.2212619291054315 0.0013671972619777 1.2621099436605317e-06 +Glycolipid catabolic process 3 6 2.27503786133358 0.0229036586887301 3.6310679611650487 6.451456310679611 0.1059933679561382 0.1697430158083476 1.434595381284437 0.7664524352299261 1.9023109688101565 0.2365791262889882 0.001050672309299 0.0561990347849709 0.0056684159955205 0.032628233248221 0.0019884945269669 +Response to endoplasmic reticulum stress 36 85 2.2746752392183915 0.0229254189144505 20.766990291262136 81.87135922330097 0.3895578367391949 0.6272162805638101 7.658618957730667 6.11384352257493 0.925049322897134 0.3624458148773257 0.0005398773551759 1.0 0.5763684861057579 0.00915168935121 1.2533897888423431e-05 +Positive regulation of cysteine type endopeptidase activity 7 25 2.273415860827653 0.0230011312332287 7.196601941747573 28.478155339805824 0.6118231968344265 0.4994143481361404 2.711480107898675 3.3256882629722657 0.9483693928307184 0.340405399390541 0.1565399085588925 1.0 0.5782406044087871 0.0637395822669413 0.1407079899645458 +Regulation of mitochondrial membrane permeability involved in apoptotic process 4 11 2.272442384208756 0.023059804207749 2.2257281553398056 10.398058252427184 0.3562513608354196 0.4987454147108047 2.2641182093491294 1.2175082450249533 0.8596932066665716 0.2788995466788783 0.0362565567617867 0.1389130578490434 0.2590666885683055 0.0379489226270714 0.0612536211646263 +Protein insertion into er membrane 6 9 2.2702216162226736 0.0231941401009392 4.451456310679611 12.691747572815531 0.9645901040516046 0.3077872373135509 2.16101217194965 1.431147904526304 1.1733171268605926 0.305304417896891 0.0016518039309861 1.0 1.0 0.097689242801984 0.0034992238505004 +Iron ion homeostasis 6 17 2.2626700244180324 0.0236560379698 4.468446601941747 17.140776699029125 1.0306963602610326 0.26770320823289 2.1032740346004313 1.762496954108992 1.1437451534606062 0.2692749918411525 0.0044439773047646 0.0248381956323572 0.08610744549237 0.0074685925596388 0.0110551101007063 +Glycolipid biosynthetic process 4 12 2.2575695655814743 0.0239725078712911 3.3009708737864076 8.701456310679612 0.8778541677747596 0.2891249509557468 2.0940737065519093 2.1465026455410077 1.206628042966233 0.2848826766737565 0.0148044043266581 1.0 0.2941077913158182 0.0106277501006418 0.0287420990175065 +Respiratory chain complex iii assembly 1 6 2.2457993761156283 0.0247168612999186 1.8470873786407769 5.160194174757281 1.360931378136811 0.1995688008303064 1.0650749835200868 1.2360161344522411 1.0120439004969468 0.2366879233397748 0.0396732061580873 0.0006219606051344 0.002465796513642 0.0147480216610697 0.0542215392640632 +Glycerophospholipid biosynthetic process 24 46 2.241769369075948 0.0249762818846683 12.407766990291265 39.55339805825243 0.6228968293784067 0.4586227574071144 6.110530292090928 7.803693618041913 1.233194093755117 0.3515784330467275 0.0311054251872543 1.0 1.0 0.1899277813657192 0.0109522124591341 +Regulation of mammary gland epithelial cell proliferation 1 5 2.238914397413549 0.0251614865165121 1.2257281553398058 3.349514563106796 0.5243048458489442 0.4429803151195659 0.924330355290862 0.9775016486374266 1.113389521287488 0.3080578603254053 0.1234662274193449 0.0697581245313758 0.1349531130589082 0.0495157384890535 0.1630814235328921 +Cellular iron ion homeostasis 5 14 2.236258724696938 0.0253348284771384 3.66504854368932 13.521844660194176 0.8677978780626455 0.311898632686956 1.8823249793116483 1.671290558583202 1.0630934740559084 0.2702936919112085 0.0046816994900874 0.1715759324473242 0.3143397790261298 0.0140312853386763 0.0105883475769395 +Regulation of lysosomal lumen ph 3 5 2.2289555045000453 0.0258168654850976 2.3567961165048543 5.58252427184466 1.1719038900849827 0.159040563248536 1.2351555175791742 1.4280428037740598 1.4707016211600112 0.2132438131163355 0.0026277975298375 0.0697581245313758 0.1349531130589082 0.0050923434600555 0.0048822579474643 +Sodium ion homeostasis 5 7 2.2286245453220843 0.025838896499722 2.466019417475728 6.349514563106796 0.2516746506702666 0.4899255287612532 1.608928570587902 0.9026254893696282 0.9888627771743224 0.3151555036236248 0.0404477004850345 1.0 1.0 0.3715199079432311 0.0618109910728358 +Vitamin transmembrane transport 4 7 2.226398130587683 0.0259875255956574 2.9344660194174756 6.094660194174757 1.6910321805591797 0.1136175735100163 1.344920850275403 0.8913122381585616 1.0580472895861666 0.1862049292817703 0.0002387045154679 0.0697581245313758 0.0088504827764808 0.000366006536683 0.0005289198821125 +Vitamin transport 4 7 2.226398130587683 0.0259875255956574 3.587378640776699 7.597087378640777 1.658661901456128 0.1256251915839625 1.8073839707699664 1.6422194495621811 1.0713624000848283 0.1994200282768667 0.0024924187730192 0.1093006244161378 0.0219975904219434 0.0024022577840735 0.0052134507581354 +Regulation of water loss via skin 1 5 2.2234975492363955 0.0261822684609509 1.3980582524271843 4.95873786407767 0.4829857617931532 0.4190090745011622 1.132827083225922 0.8422959602674207 1.0405700816787415 0.2964107522750627 0.1234662274193449 1.0 0.0088504827764808 0.0495157384890535 0.1630814235328921 +Organic acid transport 25 48 2.21028618797214 0.0270853065901937 16.199029126213592 46.1626213592233 1.6912598339530378 0.23494744574913 7.685833584742487 5.405881453891157 1.4084922190667013 0.315570201131532 0.0103136279824632 0.4854356723902606 0.3803883597337516 0.0479558757106163 0.0066360381737036 +Glycerolipid metabolic process 34 72 2.2083046502647345 0.0272230433877609 16.934466019417474 64.79854368932038 -0.000323163470851 0.4552448147740581 9.046432352430308 10.372466251166422 1.3758971299503038 0.353332456533291 0.0058420624280567 1.0 1.0 0.0361607746112721 0.0019477972361079 +Positive regulation of necrotic cell death 3 6 2.206189310678736 0.0273707474056492 1.577669902912621 5.262135922330097 0.5638344924795549 0.4335998879538771 1.168471912149588 0.9650309623137224 1.027471527178098 0.3152978961085739 0.0004758293614935 1.0 1.0 1.0 0.0009118158302113 +Amyloid precursor protein catabolic process 6 16 2.205210559832519 0.0274393225273361 4.62621359223301 16.47087378640777 1.203006467000838 0.2754962460876 2.1329801006381106 2.1803683249886516 0.947433834000198 0.2709877848980267 0.0085357436861326 0.0188245552589776 0.0666692325567911 0.0211003003498726 0.0048940429574069 +Inorganic ion import across plasma membrane 6 8 2.2014220963991624 0.0277061561480898 2.716019417475728 7.315533980582524 0.1447137088312296 0.5057120373742784 1.765207344902221 2.067419820661671 0.9830237687695068 0.3144287982892507 0.4504549508521597 1.0 1.0 0.5955662992954859 0.5423832826720252 +L glutamate transmembrane transport 4 6 2.196513149017876 0.0280552350619114 3.116504854368932 6.616504854368932 0.3175170990129407 0.3936177213286974 1.7421166172873912 0.8323084155048082 1.211420518243718 0.3212678134420738 0.0176594629498872 1.0 1.0 0.0041470760753771 0.003721367796782 +Amine transport 4 8 2.196442845195893 0.028060261828823 2.266990291262136 6.262135922330097 0.2299272116237959 0.4442677623450987 1.5333121930836977 1.471154127534574 1.0378985863521706 0.295475533106051 0.3033169802473151 1.0 1.0 0.4832891613764908 0.1410707299584872 +Peptide catabolic process 8 12 2.191569554144297 0.02841060234591 3.871359223300971 10.351941747572816 1.5413280472635258 0.1625248535751528 1.454973091229298 0.9501768442987896 1.1353491763523988 0.2229381591694359 0.0008071226260475 1.0 1.0 0.0757571260003459 0.000200465132953 +Membrane organization 80 218 2.18702913722406 0.0287403970039534 62.02427184466019 223.60922330097088 0.9560408776070136 0.5603311757674675 21.467957454898308 21.375973545731355 1.611091026762519 0.4273954777865132 5.563651858061717e-19 0.0399875865627003 1.0054448242037093e-05 8.198958690259259e-11 5.371038112107368e-16 +Import into cell 15 28 2.1819912585497354 0.0291101778819358 8.441747572815533 26.468446601941743 0.278986899549401 0.5712036628248293 4.717145431684204 4.63434566286081 0.9247855241772484 0.3264760057770247 0.2252138211472395 1.0 0.6211264656767345 0.435424260519051 0.2119543545949243 +Sterol biosynthetic process 11 28 2.180260815338523 0.0292381338963869 7.281553398058253 24.52912621359223 1.190088798384403 0.3136799329736269 3.292879861326439 2.61838648411319 1.1232845583768152 0.3105481837594456 0.0001002973472817 0.2030241760545403 0.0748026769138462 1.4280312346792963e-05 1.1206321672316697e-05 +Regulation of leukocyte degranulation 1 8 2.1739321337938 0.0297102323562659 1.6699029126213591 6.470873786407767 0.5853711877145334 0.3457823611194687 1.4305158925119918 1.701406104268744 1.0992219708926214 0.2597166324139169 0.2265412972075606 0.1006582454154426 0.191600110602388 0.097689242801984 0.2898287915273368 +Carboxylic acid transport 19 36 2.169058444501552 0.0300782470673846 12.351941747572816 33.69417475728155 1.517249458545343 0.2522623764771551 6.23371050940395 4.11174791553619 1.419876490432768 0.3135855212793009 0.001164773313713 0.0904452781629929 0.0801526286479979 0.0009591833312121 0.0016584439445074 +Lactation 4 12 2.166133907902386 0.0303009557793692 3.2402912621359223 11.305825242718448 0.5550214141434973 0.4814819551144184 1.865118729821621 1.366614784589971 0.8532521714833784 0.3023533937292395 0.0078803131844108 0.1389130578490434 0.0354914601129098 0.1713585638073601 0.0157766780310383 +Amyloid beta formation 5 11 2.165104007281371 0.0303797211678431 3.4466019417475726 11.150485436893204 0.7369482521385301 0.3719348072839057 1.602353580483856 1.6769930201386472 1.043709172018907 0.2948415726419107 0.0116776996200851 0.0115082778780227 0.0420348553288257 0.0479498850625808 0.0053527619374205 +Positive regulation of peptidase activity 12 39 2.164806238535875 0.0304025268673318 10.402912621359222 41.05582524271845 0.5528457293594794 0.5353148532065843 3.6877903061155113 4.060739093918417 0.9383664509883394 0.3555881721715914 0.0596524836274248 1.0 0.6913649792128338 0.0724012208448934 0.0143684953141881 +Regulation of necrotic cell death 5 11 2.153883783652725 0.0312492869896183 2.6771844660194173 11.71359223300971 0.2977530378262362 0.4578180986081704 1.5454800476301118 1.252380145124011 1.0198350476395044 0.2956255904252384 0.0006425116636896 1.0 0.2297987482657219 0.4832891613764908 0.0015706126808535 +Positive regulation of mitochondrion organization 7 23 2.152153255494514 0.0313852858713092 6.235436893203883 22.393203883495147 0.6669540243221574 0.4355223453199826 2.7589935116766484 2.962672702300372 1.01251720769805 0.3295170825531805 0.0012871525254375 1.0 0.0919415891551245 0.0016490180911792 0.00375910232126 +Ceramide transport 1 7 2.150310581569468 0.0315306559550927 1.779126213592233 5.310679611650485 0.994079753441996 0.2057455404068654 1.027416031856974 0.785538294365343 1.3065287972688011 0.2361222749942 0.0966882498554272 0.0607401038440192 0.1180585699575878 0.0379575415698398 0.1289341732663725 +Antigen processing and presentation of endogenous peptide antigen 6 8 2.1493339123774824 0.0316079401092823 2.638349514563106 6.390776699029126 1.097011591019633 0.2766562869747734 1.460743657586565 1.3760123823390067 1.0015631459591094 0.2785574288267012 0.1098597143392657 1.0 1.0 1.0 0.0003671727016274 +Antigen processing and presentation of endogenous antigen 6 8 2.1493339123774824 0.0316079401092823 2.6529126213592233 6.463592233009709 1.0779744166035472 0.2832041157954688 1.4492771087670022 1.3990755299770097 1.00991421519493 0.2818848392729987 0.1234662274193449 1.0 1.0 1.0 0.0005289198821125 +Tail anchored membrane protein insertion into er membrane 5 7 2.146258394349096 0.0318523690275163 3.237864077669903 9.78883495145631 0.7455035093084798 0.3610190702677224 1.8292985819470449 1.3170176672565082 1.0475888307659635 0.3008611564480194 0.0033918567435536 1.0 1.0 0.3236592382947187 0.0062633876942655 +Phosphatidylglycerol metabolic process 5 12 2.1459703293360337 0.0318753459749365 3.7572815533980584 10.78640776699029 0.7074456860764219 0.3298030384317407 2.521619218643941 1.658461595229837 1.2128783939533223 0.2875854965146425 0.0004120234665719 1.0 1.0 0.0215683584236732 0.0010205277760807 +Atp synthesis coupled proton transport 3 11 2.145504597684733 0.0319125242155893 4.067961165048544 11.769417475728156 0.4798560195228825 0.3249136059986872 2.5150503707528173 0.8937412640542226 1.340203957668315 0.2941072770431484 0.0079340930061556 0.0919337377678228 0.0155240337321844 0.0828772873031817 0.0143001062154138 +Regulation of autophagy 22 92 2.14406928685892 0.0320273355430875 20.118932038834952 94.3495145631068 0.711099590941891 0.531831837860264 6.9602150135047 11.998348379757145 0.9791686068293384 0.3767967479294735 0.00808860377467 0.3774217541644473 0.0045852906967846 0.0146601275631059 0.0067670833059855 +Selective autophagy 10 27 2.1437808254708064 0.0320504524113047 7.861650485436893 28.031553398058257 0.6116968756419903 0.5194450063363468 3.450451665126401 4.3159755745103565 0.9002253779314615 0.3454803983634653 0.0191555946547616 1.0 0.4775398588675821 0.4834399233654581 0.0048394274978242 +Mitochondrial electron transport ubiquinol to cytochrome c 1 5 2.141824624717392 0.0322075970961799 1.5048543689320388 4.206310679611651 0.8658650693935839 0.2665349265497743 0.9514810775456936 0.7935779738409815 1.3072925004771625 0.2886561243868636 0.0496528042147836 0.0007972103198291 0.0031504918831051 0.0186627473263165 0.0675218785318175 +Negative regulation of mitochondrion organization 6 15 2.1412800957564397 0.0322514572638119 4.148058252427185 15.354368932038836 0.2912247280514271 0.5498435069117807 2.316031321892106 1.7545102322731794 0.8222100433915656 0.2937386563478433 0.0030984377022794 1.0 0.2941077913158182 0.0552623668853733 0.0071436537580251 +Triglyceride metabolic process 6 12 2.141024962322833 0.0322720250949113 3.4805825242718447 10.771844660194176 0.9779567044833 0.270555786798488 1.9834538010888536 2.3392770219831345 1.099054194056709 0.249087443977639 0.0156631635216302 1.0 1.0 0.1193188519501932 0.0099411678564375 +Sodium ion transmembrane transport 8 21 2.1409277057099 0.0322798684900722 6.230582524271845 19.861650485436893 0.3704792335969762 0.5741696766418313 3.3118992073574036 3.0326356242212613 0.8979196459015502 0.333569210239074 0.3400037182198978 1.0 1.0 0.5217398143434403 0.4653980221544829 +Mitochondrial electron transport cytochrome c to oxygen 4 6 2.140758547186053 0.0322935144061959 2.6189320388349513 6.021844660194175 0.7576771538928655 0.3133819177040797 1.4641113893518565 0.9306060741204804 1.2097595052740109 0.2966582872605096 0.001050672309299 1.0 0.1094892401774078 0.0025975272437437 0.0019884945269669 +Lipoprotein biosynthetic process 4 14 2.126924110962875 0.0334263891651036 3.837378640776699 12.817961165048544 0.5159177916871569 0.4870101230655305 2.4216380804227313 3.0215034704254133 0.9442820469649724 0.3192432047465013 0.1322454036046216 1.0 0.1323300889211223 0.2130027955338551 0.2160232841208998 +Glycosylation 13 48 2.1253354277424923 0.033558634118221 13.33495145631068 45.42718446601942 0.831363055351092 0.4028474919440285 5.5712021107485015 7.578523489860055 1.3433056638769032 0.3649215649501745 0.3439885607198603 1.0 0.4634232241325184 0.0971497694423278 0.2620647957562526 +Proteoglycan biosynthetic process 4 9 2.1156346364893084 0.0343758936469109 2.6432038834951457 6.677184466019417 0.8965384350791714 0.2873226841395866 1.6239641738792057 1.992745053805788 1.1569297556833695 0.2755887487741971 0.1709084776865578 0.1553991536419083 0.2872333566147377 0.051542815486873 0.2403376761227438 +Alcohol biosynthetic process 13 37 2.1137201584919385 0.0345391757188764 9.344660194174756 36.09466019417476 1.0726679306851277 0.3539682718575088 3.792896481514287 3.1078151772256564 1.1587776417647702 0.3419459456532639 0.0008792451793853 0.3467229085425889 0.0101118666995626 0.000259969323856 0.0003020180276992 +Amyloid beta metabolic process 5 13 2.113555979963765 0.0345532089775182 3.6771844660194177 13.24514563106796 0.6724101183977472 0.416551332754989 1.8088680779022668 1.8049556184618043 1.0101286409291856 0.3102485572243311 0.0249426864182524 0.0164667175849867 0.0588586045542952 0.0756846958642696 0.0134528362725409 +Toll like receptor signaling pathway 8 15 2.1126377096334337 0.0346317885250542 3.6529126213592233 14.475728155339803 0.4591583663944621 0.4629288770135975 2.064121680704246 2.5201890058346033 0.9793418922124256 0.3026110620517385 0.3306252404981036 0.290515894493261 0.497470817800254 0.5142322444830374 0.2615198437110484 +Positive regulation of membrane permeability 4 12 2.109159349881541 0.0349308293834114 2.5072815533980584 11.643203883495143 0.2269937636120353 0.5383604388671438 2.540439031767096 1.358674906709048 0.8376135549550077 0.280421182909613 0.0442625920896186 0.1471951297158956 0.2732850813359189 0.0444854600227105 0.07392944267488 +Mitochondrial calcium ion transmembrane transport 8 10 2.105722096225383 0.0352284993019202 3.4684466019417477 9.04126213592233 0.7792467211325117 0.2463779000555085 2.196969341156949 1.2010296388602075 1.3738174116662032 0.263849842646199 0.0255771152801701 1.0 0.0100519320580488 0.0557098434243155 0.0062633876942655 +Midbrain development 4 18 2.1025473194208395 0.0355053591081802 4.706310679611651 19.65776699029126 0.3119231503214399 0.579247250306076 2.8040641414388903 1.6166196495581584 0.8520585015288774 0.3176882217380689 0.4031675123880478 0.0295498589150116 0.1009015630926116 0.3929907866903629 0.5157725074249294 +Glycolipid transport 3 5 2.101480598083308 0.0355987993886595 1.4368932038834952 3.2184466019417477 0.6463265816527453 0.2804806185071016 0.8495561709644135 0.7701024484633391 1.4290734526194493 0.2737963170174182 0.0001693477472854 0.0378187125466048 0.0743799864466655 0.0147480216610697 0.0003286021100258 +Cell recognition 5 25 2.0963275448547347 0.0360531448980121 5.29126213592233 22.859223300970875 0.9056944851933356 0.3618031966115522 2.859598274322472 2.538937048941188 0.9847101891513528 0.3060121099700091 0.037744522701097 0.0345877004093447 0.1163398228410075 0.0593060830293246 0.0744808849197366 +Endochondral bone morphogenesis 2 7 2.0958308364726874 0.0360971998512962 1.6480582524271843 5.594660194174757 0.7038217123315962 0.3729755664973352 1.1864612949328115 1.0785960989759678 0.9833570305213049 0.2787707264141815 0.1135131683065525 1.0 0.2445730022705269 0.154226710893935 0.1645088237572309 +Phosphatidic acid metabolic process 5 8 2.0917435453961257 0.03646146291297 2.2233009708737863 6.235436893203883 0.8816881639607732 0.2856229767394486 1.614148841412113 1.5439850574626743 1.1927985254107716 0.2824496640110863 0.0881871975325996 1.0 1.0 0.1292409073430241 0.0351238878380088 +Mitochondrial outer membrane permeabilization 3 10 2.089006581170469 0.0367071307542463 2.058252427184466 9.398058252427184 0.4166985454185071 0.4778198341641127 2.0471398125210385 1.2175082450249533 0.8688429204730376 0.272643251107441 0.080341967055845 0.1135912525516411 0.2147385524083838 0.0215683584236732 0.1188827437046941 +Leukocyte differentiation 14 66 2.0868999235070333 0.0368971818196619 13.259708737864075 62.82281553398058 0.2230074329146526 0.6311707774623282 5.891661699815195 7.755058720737631 0.8147397072079771 0.3290680435049292 0.132648045595762 0.7283828634776658 0.2549292906102651 0.4660491632984266 0.3168450002101647 +Adult locomotory behavior 4 13 2.0832510380932754 0.037228347123468 3.95873786407767 14.822815533980584 0.7389907423501648 0.3383620981823156 1.833016072372531 1.4878680371825237 1.1254592435779416 0.2897204029443448 0.0226355949376145 0.1755724648168266 0.0065760397653667 0.0153023562212604 0.0428945912137629 +Mitochondrial atp synthesis coupled proton transport 3 10 2.072791712577571 0.0381916680442204 3.9927184466019416 10.769417475728156 0.5022502301293951 0.29867761594221 2.4440229028906213 0.8937412640542226 1.3849431163992842 0.2834040324316194 0.0053451996563463 0.083126337411673 0.0126574737404708 0.0688460117016781 0.0097510399506001 +Hormone metabolic process 11 28 2.0654388817617884 0.0388814928394871 8.95631067961165 28.65776699029126 1.130508313948193 0.2963365150575847 3.9674689274001818 2.5345884681715156 1.346801337886388 0.3240077568826507 0.0061743984510638 1.0 0.0665208936004256 0.2065419644463913 0.002487044867352 +Apoptotic mitochondrial changes 10 31 2.0622866313919626 0.0391804550376275 8.33495145631068 31.9126213592233 0.3104951463965997 0.5709370276570955 3.5539451273925566 2.6332703138780773 0.8593316992754738 0.3196919958634499 0.0001917153940671 0.3007677906227077 0.034172513126223 0.0019875963928334 0.0008219521444205 +Granulocyte differentiation 3 8 2.059962401920454 0.0394021353023885 1.924757281553398 6.616504854368932 0.6538759680726012 0.4421743939057452 1.4703109404055 1.0041271229792812 0.8899903394686414 0.3097902328583951 0.0065553535310396 1.0 0.1677870330809631 0.0101015401572799 0.0118865434534573 +Tetrapyrrole biosynthetic process 6 14 2.057780708916098 0.0396111887000938 3.978155339805826 12.308252427184469 0.3532525135599431 0.4350645652075638 2.0813570291196224 1.845916473083467 1.0884111669512433 0.3019410049691661 0.0006425116636896 1.0 1.0 0.0264830942684438 0.0015706126808535 +Regulation of leukocyte mediated cytotoxicity 3 7 2.056186074841112 0.0397645839957512 2.5825242718446604 7.334951456310679 0.4511695306521209 0.4227043221453989 1.4499700153890709 1.2995300672557608 1.082342679990832 0.3098039206468536 0.2572343334310336 1.0 1.0 0.4439075633632242 0.32624452618512 +Cellular response to chemical stress 22 72 2.0552505343872336 0.0398548123998552 15.75728155339806 79.70145631067962 0.402779466671678 0.6562176319163813 6.265123092751621 7.907578877532739 0.7656094121344978 0.3407433272819883 0.2640705340123362 0.6849978745028327 0.1937160432811581 0.6814641626617373 0.177583313752994 +Oligosaccharide metabolic process 2 5 2.049871631740116 0.040376959152792 3.0606796116504853 6.179611650485437 -0.0148577354153068 0.2267163537664357 1.4017006052191363 1.1242135739548185 1.7186048285621385 0.2671195008920222 0.0656286176794259 0.1049896535105009 0.1993869387044997 0.4301270919610729 0.0981468657129251 +Cerebellar cortex development 4 12 2.038660452356207 0.0414839273344707 3.2014563106796117 12.951456310679612 0.4913835354280507 0.4216383686135529 1.7737836843231067 1.855867843348426 1.0191189701346923 0.2901119129344551 0.0131785756289622 0.1553991536419083 0.0443091130960601 0.0096252938706505 0.0257423149537502 +Maintenance of location 15 65 2.037396978854125 0.0416102763811931 14.529126213592232 67.10194174757281 0.2761251361558006 0.5437230382448518 5.781761264023897 6.826866977938762 1.0069098531292424 0.349986956897805 0.0165189110699372 0.070184605369373 0.012227438591947 0.1087797558540629 0.0327354438925712 +Glycerophospholipid metabolic process 31 65 2.036881934637526 0.0416618748941552 14.597087378640778 57.060679611650485 -0.0519222534779674 0.4286122989812534 8.002292830543196 9.368077769293231 1.3877870839733877 0.3500560744701435 0.0103883178920161 1.0 1.0 0.0618394993168289 0.0053852596723808 +Chloride transmembrane transport 4 6 2.036584820235869 0.0416916652433625 1.9271844660194175 5.497572815533981 1.0121969151812915 0.2503571453769561 1.6864793094247907 1.5080669592016671 1.1003731395705292 0.2453144412674818 0.0301377643441986 1.0 0.1515272625734178 0.0073447144383531 0.0465653262864464 +Autophagy of mitochondrion 12 32 2.035735086064345 0.0417769638931839 8.643203883495145 32.55582524271845 0.5912176019297528 0.507260115546458 3.9310041488944902 4.499114265424183 1.01585008111736 0.3556742421157408 0.0002441054384553 1.0 0.1656331484196294 0.0099323103632579 0.0002721241528285 +Skeletal system morphogenesis 5 21 2.035174237948709 0.0418333442592362 4.259708737864078 18.354368932038835 0.472602243504248 0.5428135061071451 2.346868997179785 3.0862449832926195 0.7734532956175788 0.3019127996783903 0.3526468566006959 1.0 0.3139585525038253 0.3178680488857411 0.5135376891683734 +Cation transport 61 153 2.0302579486962467 0.0423303262310248 40.9247572815534 152.4733009708738 1.0106305648473772 0.4693050539746304 15.98502541638414 15.374508146736815 1.5607432077940149 0.4143686874753333 1.3089161621502766e-05 0.4300237614022896 0.0028040551109991 0.0009208749663371 7.476668874281382e-05 +Atp metabolic process 37 116 2.0255724838729376 0.0428086136454273 25.97087378640777 107.69417475728156 0.2650120939459569 0.5409439866831242 10.270805368899644 8.059768543771504 1.2580915670575048 0.3757529915372982 8.361113956475398e-09 6.04225173957395e-05 5.32248422643978e-06 1.3336237801254048e-05 2.015555445541828e-09 +Chemokine production 2 10 2.0224773966670835 0.04312705641295 1.8810679611650485 8.337378640776699 0.9152793985046536 0.327029475914965 1.2820382835273771 1.4780796128991345 0.9350060766690576 0.2657366976150246 0.1412206545018741 0.1430638950507344 0.266209970857853 0.1800390494619342 0.2015708610705285 +Outer mitochondrial membrane organization 2 5 2.021317511062215 0.0432469075953181 1.4296116504854368 4.956310679611651 1.1531610290328034 0.2630141305877053 0.9963023114429655 0.2044029443827893 0.89744850896642 0.2676384061848394 0.0006386647024925 0.0238038053541035 0.0471521402185075 0.0055254488719224 0.0010568895936515 +Sterol metabolic process 16 43 2.0201944805869285 0.0433632185797081 11.932038834951456 38.44660194174757 1.1656335789111734 0.2523239777622673 4.346099994655023 4.0619669904912925 1.6676089351046874 0.3062687621764124 7.85520910102964e-06 0.3371313972628795 0.0089732445190698 5.692764928188808e-06 2.631621948630412e-06 +Regulation of oxidative phosphorylation 3 10 2.016372253923665 0.043761064609616 2.0266990291262137 8.405339805825243 0.5212596953879275 0.3786062166885635 1.6210885042287937 1.4888813260225289 1.142050430358633 0.295953719868097 0.0033918567435536 0.0026008925831016 0.0100519320580488 0.0061570039439817 0.0062633876942655 +Regulation of cysteine type endopeptidase activity 14 47 2.0151666794011023 0.0438871875408473 11.024271844660197 48.30339805825243 0.4412193551169824 0.5489802671194735 4.186129802361243 4.9529522535570285 0.919025397001871 0.3400648922313719 0.1275902663854617 1.0 0.7486901962419026 0.0561441542312813 0.0844568589299133 +Hormone biosynthetic process 5 8 2.0136049491953134 0.0440510264109679 3.2766990291262137 8.762135922330097 0.5893833627772115 0.3611309387757575 1.7820956292372838 1.0801489024333786 1.1172063688590312 0.2892911953740955 0.0201952000669413 1.0 1.0 1.0 0.0074494564855197 +Regulation of amino acid transport 3 6 2.008943022732306 0.0445431765976824 2.0072815533980584 5.410194174757281 0.2341391908074453 0.4393034616097434 1.3301745955731776 1.103477715720748 1.0376662325790424 0.29199546311681 0.1234662274193449 1.0 1.0 0.3069124011154697 0.1630814235328921 +Peroxisome organization 4 11 2.0073404319933985 0.0447134268085887 4.286407766990291 11.196601941747574 0.606295801393023 0.4614466229190617 2.3307796330420754 2.613015983661412 0.9820420209440194 0.3193147518558685 0.363844542989374 1.0 1.0 0.5315101420828222 0.4482773855235765 +Protein localization to lysosome 3 14 2.0000673772270963 0.0454929888633226 3.5364077669902914 14.37621359223301 0.6191344010889903 0.3619681772746835 2.0811532251007954 2.18038858944462 1.1869570048706093 0.3022181269423334 0.0629956136787357 0.1635258499471353 0.048990890514732 0.0591065206713347 0.1028731839020021 +Regulation of biomineralization 3 8 1.996360760421971 0.0458946687442978 2.0 7.254854368932039 0.7087493386381231 0.4293372114928327 1.648771240027478 1.7124900192906916 0.7924172542279996 0.2810900644904195 0.8479087125406758 1.0 0.3530974878629287 0.6676078298658026 0.6495498386383816 +Macroautophagy 40 105 1.9878697493613733 0.046826097152983 25.570388349514563 102.68203883495146 0.4734815024857951 0.6429834425349866 8.949285204664525 14.162660044372751 0.8554944786686205 0.3590213706304501 0.012473504721467 0.725682415483212 0.0421785295728204 0.0563160626961836 0.0023987970858388 +Calcium import into the mitochondrion 6 7 1.9877601372911395 0.0468382243670388 2.4563106796116503 6.04126213592233 0.8091317576129835 0.2214807715451704 1.7082137325011066 1.2010296388602073 1.3762222767333927 0.2421218388926935 0.0840134225210092 1.0 0.1094892401774078 0.2541534411772372 0.018020673376298 +Oligosaccharide lipid intermediate biosynthetic process 3 5 1.987683063132352 0.0468467532476872 2.2742718446601944 5.390776699029126 0.4920123476052065 0.3335995467983793 1.5024311055989734 1.8021595402153228 1.3008390374829126 0.2934249582958821 0.0350962772824537 1.0 1.0 0.0688460117016781 0.0539281835546241 +Er overload response 3 5 1.9862304584114807 0.0470077402941613 1.837378640776699 4.473300970873787 0.5113243262281758 0.4611923313960993 1.086215896190079 0.6585994087920162 0.9725988758473914 0.3191192692053483 0.0065740916466848 1.0 1.0 0.0229613270793894 0.0105668672564949 +Body fluid secretion 4 14 1.985047240095473 0.0471392159082886 3.611650485436894 13.691747572815531 0.5614164790218804 0.4834047231691153 2.085469888187935 1.6735027663843434 0.894552067234308 0.3061879015966331 0.0356515059560401 0.1952735388158895 0.0693457394610891 0.2961580697833918 0.0655768501043339 +Protein catabolic process in the vacuole 4 8 1.9835973673004064 0.0473007429397618 2.70873786407767 6.618932038834951 0.8383076008345888 0.2101105309103242 1.6017652153393662 1.88837291272598 1.5176899437744062 0.242508547144668 0.0079340930061556 1.0 0.1758008751515455 0.0116756742779249 0.0143001062154138 +Lysosomal protein catabolic process 4 8 1.9835973673004064 0.0473007429397618 2.6941747572815533 6.587378640776699 0.838918419522322 0.2080383809566978 1.5899151374262637 1.8707342212441815 1.5239608036504366 0.2420459791980847 0.0053451996563463 1.0 0.1596960736798767 0.0086586519898169 0.0097510399506001 +T cell activation 18 58 1.9785921337730408 0.0478619460242799 11.87135922330097 56.20145631067961 0.3819132128629459 0.6116920144187052 4.9576316669096165 6.2667792486255545 0.7788461990309965 0.3330306669624288 0.2238820418998069 0.6707070078118527 0.176363523212896 0.4732306103724762 0.3150208054958285 +Regulation of hormone metabolic process 2 5 1.976349634438368 0.0481151916842581 1.9199029126213591 5.327669902912621 0.9387613573830266 0.3058102715557096 1.1578738425382251 0.5676654694542113 0.9983912186719198 0.2773016546183636 0.0461853959222372 1.0 0.1758008751515455 0.3867116248199588 0.0701952648708137 +Glycoside catabolic process 3 5 1.9748694592230007 0.0482829640542499 2.995145631067961 5.604368932038835 0.914408298188202 0.1915126053981477 1.4021397407455505 0.554137429771367 1.5051386650706404 0.245673751384095 0.0032614075814128 1.0 0.0743799864466655 0.0147480216610697 0.0053031795330487 +Positive regulation of response to endoplasmic reticulum stress 3 6 1.974109868174333 0.0483692515069282 2.599514563106796 7.531553398058253 0.8024117711160038 0.3682526496548435 1.5726113825314656 1.2719812977815077 1.0103793589126204 0.3058642465956152 0.0259503462691174 1.0 0.2372212797486779 0.1457934990596532 0.0446088038944012 +Cellular sodium ion homeostasis 3 5 1.9736454478773613 0.048422072152221 1.7645631067961165 4.279126213592233 0.3130666300494188 0.4596282540439977 1.2029117398149052 0.6440551245721169 1.0188577401619887 0.3109798964466274 0.0840134225210092 1.0 1.0 0.2541534411772372 0.1125747569923622 +Mammary gland epithelial cell proliferation 1 6 1.9690877756924516 0.0489430123610523 1.5 5.25 0.3625881460002983 0.5128071511243121 1.207782208876116 1.3467418432027014 0.9074645670527792 0.3044724408899644 0.2572343334310336 0.1093006244161378 0.2070995190727305 0.1131762501747812 0.32624452618512 +Golgi vesicle budding 2 5 1.968832317012893 0.0489723498884728 2.361650485436894 5.885922330097087 0.3884971997185341 0.3730735107085309 1.2258483070977126 1.4275703691993364 1.1967984324527177 0.3049192576690944 0.0065740916466848 1.0 1.0 0.2167775624926856 0.0105668672564949 +Organelle disassembly 14 48 1.9683602086580971 0.0490266068645544 11.983009708737864 49.20388349514563 0.433561938027762 0.6160490735942882 4.954374615918461 6.142102393453674 0.8047024382669711 0.3415228222424311 0.0009821346150491 1.0 0.2605001929873321 0.0382007550618062 0.0004329548950732 +Regulation of mitophagy 3 6 1.9635717468485427 0.049579776541955 2.033980582524272 6.730582524271845 0.7938894190377023 0.2859156513857533 1.5052692819802862 1.0417203147023346 1.2011910390869405 0.2760404746280959 0.0113404336176026 1.0 0.1094892401774078 0.2541534411772372 0.018020673376298 diff --git a/msigdb_gobp/metrics.json b/msigdb_gobp/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..53d49ee887f35dbde41ba8febd6298509163368d --- /dev/null +++ b/msigdb_gobp/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3221, + "annotations_size": 6513, + "title": "Average number of proteins per term", + "value": 19.176569937048978 +} \ No newline at end of file diff --git a/msigdb_gobp/paths.json b/msigdb_gobp/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..cc14a2bb60482de5d962aba69b1e0c0557aa2042 --- /dev/null +++ b/msigdb_gobp/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/msigdb_gobp/fragment/C201/C201_val_log2fc"} \ No newline at end of file diff --git a/msigdb_gobp/result.tsv b/msigdb_gobp/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..01759d3d4972125a8a54e4fc50a9b0eb2ddfe799 --- /dev/null +++ b/msigdb_gobp/result.tsv @@ -0,0 +1,1763 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Mitochondrial transport 0.6848734267967279 4.521848182875553 6.130202176546362e-06 0.0391395838970629 0.0399260067758529 84 Q9P0J0,P06576,P52789,Q8N4H5,P56385,P05141,P30536,Q9NS69,Q99797,O43615,Q10713,O60830,O14925,Q5JRX3,Q6NUK1,Q9Y5J9,P24539,Q9Y512,P45880,P50416,O96008,O14737,Q9Y5J6,O95831,Q8N8Q8,Q8TB36,Q15388,Q9Y371,Q15070,Q969V5,O75964,O75431,P23786,Q8IXI1,Q9UJS0,O95140,O00165,Q9UBX3,P51572,P04637,Q53H12,P16260,P12235 43 +Mitochondrial membrane organization 0.7596380333576632 4.252840787888164 2.1107564940336943e-05 0.128443879973354 0.0687367852282105 48 Q9P0J0,O60313,P52789,Q9NVH1,Q9NS69,Q9Y5J9,Q9Y512,P45880,Q16891,Q13505,Q6UXV4,O14737,Q9Y5J6,O95202,Q9H3K2,Q8N8Q8,Q15070,Q969V5,Q9NX63,O75431,Q8IXI1,Q8IWA4,Q5XKP0,O95140,P04637,Q9BUR5,Q53H12,P12235,O00203 29 +Membrane lipid metabolic process 0.7840904896837178 4.090537082787961 4.303753887313633e-05 0.2444501545232807 0.091166875948823 40 Q96G23,P06865,O15269,Q9NZ01,P16278,P50897,P07602,P17900,Q9P035,P06280,Q13510,O95470,Q16739,Q16880,P04062,Q99735,Q8NBX0,Q9NZJ7,Q53H12,Q5H8A4,Q06136 21 +Sphingolipid metabolic process 0.8181885255176842 4.0025259849532855 6.26697823002953e-05 0.335141526356824 0.091166875948823 30 P16278,P50897,P07602,Q16739,P17900,Q9P035,Q9NZJ7,Q16880,P04062,Q13510,Q96G23,O15269,Q53H12,O95470,Q9NZ01,Q06136 16 +Protein localization to mitochondrion 0.6542614969281889 3.976325239464836 6.998838933580664e-05 0.3660912941816654 0.091166875948823 58 Q9P0J0,P52789,Q8N4H5,P30536,Q99797,Q9NS69,O43615,Q10713,Q9Y6C9,O60830,O14925,Q9Y5J9,Q9Y512,O96008,O14737,Q9Y5J6,O95831,Q8N8Q8,Q8TB36,Q15388,Q9Y371,Q15070,Q9NX47,O00165,P51572,Q53H12,O00203 27 +Oxidative phosphorylation 0.5995883628820468 3.8918286828425512 9.94914894925092e-05 0.4769197096425391 0.1020613076637217 64 O14949,Q9BSK2,P06576,P20674,P56385,Q7KZN9,Q9UDW1,P09622,P22695,P03886,O43676,O95139,O14548,P14406,P24539,P08574,O75323,P00403,Q04656,Q9H3K2,P13073,O95168,O95299,O96000,O75964,Q9Y6M9,O75208,P51970 28 +Anion transport 0.6015710224825648 3.868086419767898 0.0001096927919002 0.5105477353591862 0.1020613076637217 75 Q9HC21,O00400,O43681,Q14728,P05141,Q9C0H2,P30536,Q9H2D1,Q9NW15,P55011,Q4KMQ2,P53007,Q6NUK1,P07602,Q8TB61,P45880,P21796,Q9UHG3,P51798,Q6KCM7,P0CG08,Q9BQT8,Q9Y277,Q15043,P30825,Q15041,P51790,P12236,O60831,Q9UJS0,O75746,Q9UBX3,P04920,Q9NZJ7,Q7L0J3,Q96S66,P12235,Q08722,O75915,Q9Y619 40 +Mitochondrial transmembrane transport 0.6788013494739684 3.7960827124696297 0.0001470004706989 0.6161427125424647 0.1196767582077692 51 Q9BSK2,P06576,Q8NE86,Q96AQ8,P56385,P05141,Q9H2D1,O43615,P53007,O60830,O14925,P24539,P21796,P50416,O96008,Q6P4A7,O95202,O95831,Q15388,Q9BQT8,Q8WWC4,O75964,Q9BPX6,P23786,P12236,Q9UJS0,Q9UJZ1,Q9H9B4,O75746,Q9NUT2,O75027,P12235,Q3ZCQ8,Q9Y619,Q00325 35 +Inner mitochondrial membrane organization 0.8021824829813753 3.6713658272524863 0.0002412577225416 0.7922668847522032 0.1641123312554644 22 Q9P0J0,Q5XKP0,Q9Y5J9,Q9H3K2,Q9Y512,Q13505,Q16891,Q9BUR5,Q6UXV4,Q53H12,Q9NX63,O75431,Q9Y5J6,O95202 14 +Membrane lipid biosynthetic process 0.7800918963808336 3.660242609478052 0.0002519765565107 0.8062778009066498 0.1641123312554644 25 Q16739,Q9P035,Q8NBX0,Q16880,P04062,Q13510,Q96G23,Q53H12,Q5H8A4,O95470,Q06136 11 +Electron transport chain 0.5670056936379073 3.610396029231727 0.0003057298379685 0.8635125874265036 0.1677691527213072 69 O14949,Q9P0J0,P20674,Q7KZN9,Q9UDW1,P09622,O43819,P03886,O43676,O95139,O43175,O14548,P08574,P00403,Q99643,O15460,P16435,P48163,Q9H3K2,P13073,O95168,O95299,O96000,P04062,Q9Y6M9,O75208,P21912,Q9UJS0,O75746,P51970 30 +Sphingolipid biosynthetic process 0.8533066552049783 3.5867160957414836 0.000334868568306 0.8871125800958699 0.1677691527213072 17 Q16739,Q9P035,P04062,Q16880,Q13510,Q53H12,Q96G23,O95470,Q06136 9 +Protein insertion into membrane 0.7613509126491519 3.527609988745598 0.0004193295062924 0.9348892653487068 0.1857082846852191 24 Q9P0J0,P46379,O43681,Q9Y5J9,Q8N8Q8,Q9Y512,Q15070,Q9NS69,Q9NPA0,Q96A33,Q53H12,O14737,Q9Y5J6 13 +Cellular ion homeostasis 0.5786697357377235 3.4961062412115114 0.0004721006923247 0.953834284415756 0.1857082846852191 89 P06576,Q8NE86,Q96HE7,Q9Y3D6,P20020,O75787,P55011,O43819,P05023,Q9UM00,P16615,Q96PU5,P50897,P98194,P09601,P23634,Q16891,P05067,P35670,Q04656,O95202,O76024,P0CG08,P61421,Q15043,Q8WWC4,O75503,Q9BPX6,Q96TC7,P54709,P51790,Q8N511,Q93050,Q9UJZ1,Q05086,P51572,Q15904,Q9HD20,Q9NP58,Q7L0J3,P04920,Q96A33,O75880,Q9Y487,Q96AQ8,O00203 46 +Mitochondrial respiratory chain complex assembly 0.6951013350416677 3.4807197987859912 0.0005000683331637 0.9615255030099564 0.1857082846852191 40 Q9P0J0,Q9BSK2,Q69YU5,Q9H061,O43819,Q9Y2R0,P03886,O43676,O95139,Q96CU9,Q9Y512,Q86Y39,O95831,Q8N8Q8,O95168,O95299,Q15070,O96000,Q9Y6M9,O75880 20 +Metal ion homeostasis 0.567269704949866 3.4744464229171808 0.0005119085814209 0.964382359680228 0.1857082846852191 81 Q8NE86,Q9BXP2,Q96HE7,P04899,Q9Y3D6,P20020,P55011,O43819,P05023,Q9UM00,Q9Y5X3,P16615,Q96PU5,P98194,P09601,P30519,P23634,Q16891,P05067,P35670,Q04656,O95202,O76024,Q8NE01,P61421,Q15043,Q8WWC4,Q6P4Q7,Q9BPX6,Q96TC7,P54709,Q8N511,Q9UJZ1,P51572,Q15904,Q9HD20,Q9NP58,O75027,Q7L0J3,Q96A33,O75880,Q9Y487,Q96AQ8,O00203 44 +Ceramide metabolic process 0.7941009624202369 3.4686071750169294 0.0005231638065135 0.9669011747465138 0.1857082846852191 20 Q16739,P17900,P06280,Q16880,P04062,Q13510,Q96G23,O15269,Q53H12,O95470 10 +Lytic vacuole organization 0.7474329156607767 3.4592131021747337 0.0005417560892091 0.9706778928143238 0.1857082846852191 25 P50897,P11117,Q8N511,Q96ED9,P54802,P10253,P04062,O75787,O75503,Q12768,Q9BZG1,Q14108,O00203 13 +Anion transmembrane transport 0.668155018417798 3.421781202583675 0.0006221235534624 0.9826324475433692 0.2025945351850545 44 Q9HC21,Q14728,P05141,Q9H2D1,P55011,Q4KMQ2,P53007,Q8TDW0,Q8TB61,P45880,P21796,Q9UHG3,P51798,Q9BQT8,Q9Y277,P30825,Q15041,P51790,P12236,O60831,Q9UJS0,Q9H9B4,O75746,Q9UBX3,P04920,O43808,P12235,O75915,Q9Y619 29 +Glycoprotein metabolic process 0.5536341370272365 3.3942471690673943 0.0006881755107976 0.9887076530190706 0.2041471140159817 63 Q8N6G5,Q9BT22,Q9NX62,Q96AA3,Q92542,Q7LGA3,O00754,Q8N4A0,Q96L58,O94923,Q9NQX7,P04843,Q04656,O15118,P62820,O60858,Q16706,Q86YN1,Q8NCH0,Q10472,P46977,Q2TAA5 22 +Protein targeting to mitochondrion 0.6594955601937746 3.3936887055840956 0.0006895803022188 0.988810570653835 0.2041471140159817 45 Q9P0J0,Q8N4H5,P30536,P55786,Q99797,Q9NS69,O43615,Q10713,O60830,O14925,Q5JRX3,Q9Y5J9,Q9Y512,O96008,O14737,Q9Y5J6,O95831,Q8TB36,Q15388,Q9Y371,O95140,O00165,P51572,Q53H12,Q3ZCQ8 25 +Endoplasmic reticulum organization 0.6658898147232927 3.335246988456136 0.0008522366762844 0.9961241257829092 0.2413311944626285 42 O95197,Q8NHH9,Q5JRA6,Q15363,P46379,O43681,Q15041,P57088,Q00765,Q9NQC3,Q96A33,Q9P2W9,Q9NPA0,Q9H6H4,Q12981,Q8N5M9 16 +Establishment of protein localization to membrane 0.5479264502235883 3.27360452582711 0.0010618510964781 0.9990116864841532 0.2766334476544909 82 Q9P0J0,Q4J6C6,P46379,O43681,Q15006,Q9NS69,Q9Y3D6,Q8N2H4,P56589,P40855,O60725,P61026,P98194,Q9Y5J9,Q9UGP8,P43307,Q9Y512,Q9NPA0,P27105,O14737,Q7L5D6,Q9Y5J6,O15118,Q9H9H4,Q8N8Q8,O43765,Q99442,Q15070,Q15041,Q99828,Q15904,Q9HD20,Q96A33,Q9BZG1,Q53H12,P31751,O00203 37 +Protein transmembrane transport 0.7162587071951501 3.23103928468617 0.0012334098644848 0.9996770963698411 0.307241057831887 23 O60830,O14925,O95831,P49755,Q15388,Q99442,Q9NS69,O43615,Q07820,P31751,O96008,O75298,Q3ZCQ8,O75381 14 +Cellular monovalent inorganic cation homeostasis 0.710120231756651 3.2073887275031527 0.0013394586681332 0.9998382958579471 0.307241057831887 24 P06576,Q96PU5,P50897,P0CG08,Q8N511,Q93050,P04920,Q15904,O75787,O75503,P55011,Q9Y487,P05023,P51790 14 +Monovalent inorganic cation homeostasis 0.701429720644099 3.201812446107707 0.0013656588306369 0.9998636949200924 0.307241057831887 27 P06576,P04899,O75787,P55011,P05023,Q9Y5X3,Q96PU5,P50897,P0CG08,P61421,O75503,P54709,P51790,Q8N511,Q93050,Q05086,P04920,Q15904,Q9Y487 19 +Vacuole organization 0.5990634494160594 3.2013122971828243 0.0013680317330146 0.9998657881204636 0.307241057831887 52 Q86Y82,P11117,P54802,O75787,O14773,Q6UWE0,P16615,P50897,Q96ED9,Q12768,P62820,Q9Y371,P04062,O75503,Q7Z3C6,Q14108,Q16706,Q8N511,O95140,P10253,Q9BZG1,O00203 22 +Establishment of protein localization to mitochondrial membrane 0.7888131889307508 3.1741408825612685 0.0015028072840064 0.9999442785727006 0.3238792203952757 16 Q9P0J0,Q8N8Q8,Q9Y5J9,Q9Y512,Q15070,Q9NS69,Q53H12,O14737,Q9Y5J6 9 +Cellular transition metal ion homeostasis 0.7181480107799388 3.164529931323225 0.0015533368423219 0.9999599246234678 0.3238792203952757 22 Q8N511,P09601,Q15904,Q9NP58,Q15043,P05067,O75880,Q9Y487,O43819,P35670,Q04656 11 +Organic acid transmembrane transport 0.6890148878145422 3.157496821260297 0.0015912997163594 0.9999687155701736 0.3238792203952757 29 Q9Y289,Q9H2D1,P53007,Q8TDW0,P28288,P50416,P33121,Q9BQT8,P30825,Q15041,P23786,O60831,Q9UJS0,Q9H9B4,O75746,Q9UBX3,P31751,O75915,Q9Y619 19 +Liposaccharide metabolic process 0.7384979556481424 3.142670318405304 0.0016741428379321 0.9999817770664552 0.3304149182864178 20 P16278,Q16739,P17900,P06280,Q8NBX0,Q16880,P04062,P06865,Q5H8A4 9 +Organic anion transport 0.5951251848351841 3.1242868109202013 0.0017823662881422 0.9999910056080316 0.3414279892550069 51 Q9HC21,O00400,Q9Y289,Q14728,P05141,Q9H2D1,P55011,P53007,Q8TDW0,Q6NUK1,P07602,P28288,Q8TB61,Q6KCM7,Q9NZD2,Q9BQT8,P30825,Q15041,P12236,O60831,Q9UJS0,Q9H9B4,O75746,Q9UBX3,P04920,Q9NZJ7,Q7L0J3,O43808,P12235,Q08722,O75915,Q9Y619 32 +Cytochrome complex assembly 0.8277660612205263 3.097296645048201 0.00195294336534 0.999997044836516 0.3634148610988446 13 Q9BSK2,Q69YU5,Q8N8Q8,Q7KZN9,Q15070,O75880,O43819,Q9Y2R0 8 +Transition metal ion homeostasis 0.6881214463787195 3.081237670193903 0.0020614203271127 0.9999985441024634 0.364040991971847 25 Q8N511,P09601,P30519,Q15904,Q9NP58,Q15043,P05067,O75880,Q9Y487,O43819,P35670,Q04656 12 +Respiratory electron transport chain 0.5846938667726119 3.0802747583114014 0.0020680971446274 0.999998606182358 0.364040991971847 52 O14949,P20674,Q7KZN9,Q9UDW1,P09622,O43819,P03886,O43676,O95139,O14548,P08574,P00403,Q99643,Q9H3K2,P13073,O95168,O95299,O96000,P04062,Q9Y6M9,O75208,P21912,Q9UJS0,O75746,P51970 25 +Mitochondrion organization 0.6260153246689973 3.067604522864546 0.0021578198229368 0.9999992239626804 0.3698389607049371 191 Q9BSK2,Q69YU5,Q8N4H5,Q9NVH1,Q9NVT9,P05141,Q9H061,Q9NS69,Q9Y2R0,P03886,O43676,O60830,P14406,P45880,Q13505,P21796,Q96A26,Q86Y39,O95202,P02545,Q8N8Q8,Q9Y371,Q15070,P04062,Q9Y6M9,Q5XKP0,Q9NX47,O00165,Q9BUR5,P49916,Q8NAN2,O14548,Q8N2A8,Q9Y5J9,Q96CU9,Q6UXV4,O14737,Q9Y5J6,Q99623,Q9H3K2,Q8TB36,Q969V5,Q9BWH2,Q8IXI1,Q9UG56,Q8IWA4,O75153,P51572,Q53H12,Q9P0J0,Q9NVI7,P52789,Q99797,O43819,Q10713,Q96RL7,O14925,Q9Y512,Q16891,P39210,Q04656,O95168,Q7Z3C6,Q9NX63,O75431,P04637,O75880,P12235,O00203,O60313,P30536,O43615,Q9Y6C9,O95139,O75323,Q5T9A4,O96008,O95831,Q15388,O95299,O96000,Q16706,Q9GZT3,O95140,P51970,P35232 86 +Membrane lipid catabolic process 0.855275378962777 3.0290526841191223 0.0024532189776811 0.9999998871770266 0.3996775819964763 11 P50897,P17900,P06280,P04062,Q13510,O95470,Q99735 7 +Ceramide biosynthetic process 0.8516667216827394 3.011398691721892 0.0026004716166931 0.9999999568650308 0.3996775819964763 11 Q16739,P04062,Q16880,Q13510,Q53H12,Q96G23 6 +Glycoprotein biosynthetic process 0.5585307709499036 2.991215284090563 0.0027786952070223 0.999999986530426 0.3996775819964763 55 Q04656,Q16706,Q8N4A0,Q86YN1,Q8N6G5,Q9BT22,Q8NCH0,Q96AA3,Q92542,Q96L58,Q7LGA3,Q10472,O94923,O15118,P04843,P46977,Q9NQX7,Q2TAA5 18 +Regulation of ph 0.722529885759124 2.979816827140215 0.0028842079462358 0.999999993238278 0.3996775819964763 19 P06576,P50897,P0CG08,Q8N511,Q93050,Q15904,O75787,O75503,Q9Y487,P51790 10 +Regulation of cellular ph 0.722529885759124 2.979816827140215 0.0028842079462358 0.999999993238278 0.3996775819964763 19 P06576,P50897,P0CG08,Q8N511,Q93050,Q15904,O75787,O75503,Q9Y487,P51790 10 +Protein targeting 0.5481701565682171 2.9616941479764005 0.0030595153582326 0.9999999978486468 0.4042370074976303 111 Q9P0J0,P46379,Q8N4H5,O43681,P30536,P55786,Q9NS69,Q9Y3D6,Q99797,O43615,P56589,Q10713,P40855,Q7Z3B4,Q15005,Q96RL7,O60725,O60830,O14925,Q5JRX3,Q9Y5J9,Q9UGP8,P43307,Q9Y512,P27105,O96008,O14737,Q7L5D6,P57105,Q9Y5J6,Q9H9H4,O95831,Q8TB36,Q15388,O43765,Q99442,Q9Y371,Q6ZWJ1,Q15041,Q14108,Q99828,O95140,O00165,P51572,Q53H12,P31751,P13473,Q3ZCQ8,Q9Y5M8,O75381,O00203 51 +Ion homeostasis 0.5427661582233427 2.9482945226424877 0.0031953248021601 0.9999999991141476 0.4042370074976303 107 P06576,Q8NE86,Q9BXP2,Q96HE7,P04899,P30536,Q9Y3D6,P20020,O75787,P55011,O43819,P05023,Q9UM00,Q9Y5X3,P16615,Q96PU5,P50897,P98194,P09601,P30519,P23634,Q16891,P05067,P35670,Q04656,O95202,O76024,Q8NE01,P0CG08,P61421,Q15043,Q8WWC4,O75503,Q6P4Q7,Q9BPX6,Q96TC7,P54709,P51790,Q8N511,Q93050,Q9UJZ1,Q05086,P51572,Q15904,Q9HD20,Q9NP58,O75027,Q7L0J3,Q96A33,O75880,P04920,Q9Y487,Q96AQ8,O00203 54 +Ph reduction 0.8056010503971724 2.881005717677485 0.0039640844934205 0.999999999994178 0.4042370074976303 12 P50897,Q8N511,P0CG08,Q93050,O75503,Q9Y487,P51790 7 +Proton transmembrane transport 0.6016440836997432 2.879851039025927 0.0039786310250875 0.9999999999947063 0.4042370074976303 43 P06576,O00400,P20674,P56385,P05141,Q7KZN9,Q9UDW1,P05023,O14548,P24539,P00403,Q96ES6,Q13423,Q04656,Q99623,P13073,O75964,P51790,P12235 19 +Endoplasmic reticulum tubular network organization 0.820314078878069 2.8563554294956357 0.0042853511300282 0.9999999999992878 0.4042370074976303 11 O95197,Q8NHH9,Q9H6H4,Q9NQC3,Q15041 5 +Nadh dehydrogenase complex assembly 0.644932583278496 2.840969444134701 0.0044976621590491 0.9999999999998224 0.4042370074976303 28 Q9P0J0,Q96CU9,Q9H061,O95168,O95299,Q15070,O96000,Q86Y39,Q9Y6M9,P03886,O43676,O95139 12 +Organophosphate ester transport 0.6387602012917106 2.8334813652548334 0.0046043992451607 0.9999999999999116 0.4042370074976303 30 Q9BSK2,Q9HC21,O00400,Q6NUK1,P12236,Q08722,P05141,Q8TB61,Q9H2D1,P61916,Q4KMQ2,Q7Z3C6,P12235,Q14108,Q6KCM7,Q8WTV0 16 +Intracellular protein transmembrane transport 0.6873983646554779 2.8311999031968096 0.0046373727780535 0.9999999999999288 0.4042370074976303 20 O60830,O14925,O95831,Q15388,Q99442,O43615,P31751,O96008,O75298,Q3ZCQ8,O75381 11 +Inorganic ion transmembrane transport 0.5353651357976298 2.7999219551979246 0.0051114963155649 0.9999999999999968 0.4042370074976303 114 P06576,O00400,P20674,Q8NE86,Q9Y289,P56385,P05141,Q7KZN9,P20020,Q9UDW1,P55011,Q4KMQ2,P05023,Q9UM00,P16615,Q12959,Q96PU5,P98194,O14548,P24539,P08574,O75323,P23634,P00403,P21796,Q96ES6,P27105,Q13423,Q9UHG3,P51798,P35670,Q6KCM7,O95202,Q04656,Q99623,P13073,Q15043,Q6P4Q7,O75964,Q9BPX6,P54709,P51790,Q9UBX3,Q9HD20,Q9NUT2,Q9NP58,P12235,P11413,Q96AQ8 49 +Carbohydrate derivative transport 0.6818392364346308 2.796584745754768 0.0051645864516993 0.9999999999999978 0.4042370074976303 20 L0R6Q1,Q9HC21,O00400,Q6NUK1,P07602,P12236,P05141,Q8TB61,Q96AA3,Q9NZJ7,P61916,P12235,Q08722,Q6KCM7,Q8WTV0 15 +Atp synthesis coupled electron transport 0.6017922384729691 2.7920969316241284 0.0052367665983559 0.9999999999999986 0.4042370074976303 40 O14949,P20674,Q7KZN9,Q9UDW1,P09622,P03886,O43676,O95139,O14548,P08574,P00403,Q9H3K2,P13073,O95168,O95299,O96000,Q9Y6M9,O75208,P51970 19 +Metal ion export 0.8060854960076902 2.7849903470177666 0.0053529316611118 0.9999999999999992 0.4042370074976303 11 P23634,P20020,O95202,Q4KMQ2,P05023,P35670,Q04656,Q12959 8 +Glycosphingolipid metabolic process 0.8017697225117604 2.7632179908200856 0.0057234527263365 1.0 0.4042370074976303 11 P16278,Q16739,P17900,P06280,P04062,Q16880 6 +Regulation of membrane permeability 0.6842280246089264 2.747507249281253 0.0060050181380142 1.0 0.4042370074976303 19 Q8IXI1,P52789,P04637,P45880,Q969V5,P12235 6 +Cartilage development 0.7120496914273782 2.7395484785776727 0.0061523640751757 1.0 0.4042370074976303 16 P16435,O75844,Q9NX62,Q15043,Q92896,Q92543,Q04656 7 +Divalent inorganic cation homeostasis 0.5292144790346359 2.726577910910391 0.0063994842678596 1.0 0.4042370074976303 55 Q8NE86,Q96HE7,Q9Y4W6,Q9Y3D6,P20020,Q9UM00,P16615,P98194,P23634,Q16891,P05067,P35670,O95202,O76024,Q8NE01,Q15043,Q8WWC4,Q6P4Q7,Q9BPX6,Q96TC7,Q9UJZ1,P51572,Q9HD20,Q7L0J3,Q96A33,Q96AQ8,O00203 27 +Regulation of hormone levels 0.498943349270459 2.6871608189559786 0.0072062248140407 1.0 0.4042370074976303 60 Q8NE86,Q96HE7,P30536,O75787,P05023,P40939,Q16836,Q9Y394,P42892,Q96TA1,P50416,P14735,O95470,Q9UBM7,P16435,O75844,P62820,P53985,Q8NBQ5,Q53GQ0,Q15043,Q6ZWJ1,Q9BRT2,Q9UNH7,Q92543,Q8N5M9,Q9HB40,Q8NBN7 28 +Steroid metabolic process 0.4749641477601002 2.6703870870791917 0.0075763848579812 1.0 0.4042370074976303 70 P38435,Q15392,P30536,Q15800,P05023,Q8WTV0,P05067,Q13510,Q16850,O95470,Q9UBM7,O15118,P16435,Q53GQ0,Q14534,P61916,P04062,Q15125,Q14739,P37268,O94905,P04035 22 +Regulation of blood pressure 0.7062003464904283 2.6531037526631156 0.0079755351539099 1.0 0.4042370074976303 15 Q9HB40,Q6P179,P09601,Q9UIQ6,Q9NZ08,P42892,P20020,O75787,P05023,Q9Y5X3 10 +Cation transmembrane transport 0.5274580088205372 2.646652276477454 0.0081292895646694 1.0 0.4042370074976303 121 P06576,Q96AQ8,O00400,P20674,Q8NE86,Q9HC21,P56385,P05141,Q7KZN9,P20020,Q9UDW1,P55011,Q4KMQ2,Q9NW15,P05023,Q9UM00,P16615,Q12959,Q96PU5,P98194,O14548,P24539,P08574,O75323,P23634,P00403,P05067,P21796,Q96ES6,P27105,Q13423,P35670,Q6KCM7,O95202,Q04656,Q99623,Q70HW3,P13073,Q15043,P30825,Q6P4Q7,O75964,Q9BPX6,P54709,P51790,Q9H9B4,Q9HD20,Q9NUT2,Q9NP58,P12235,P11413,Q9Y619 52 +Porphyrin containing compound metabolic process 0.686529915935835 2.643791283368618 0.0081983191816854 1.0 0.4042370074976303 17 P22830,P09601,P30519,Q9NP58,Q7KZN9,O00264,Q9P0S9 7 +Connective tissue development 0.6164743015158513 2.6279436898080855 0.0085902734319758 1.0 0.4042370074976303 27 O75844,Q9NX62,Q15043,Q92896,O15173,Q92543,Q6KCM7,Q04656 8 +Cristae formation 0.809922185282672 2.62431474264045 0.0086823510965861 1.0 0.4042370074976303 9 Q5XKP0,Q9Y512,Q16891,Q9BUR5,Q6UXV4,Q9NX63,O95202 7 +Bone morphogenesis 0.7904307088914871 2.6145256001458224 0.0089351464230491 1.0 0.4042370074976303 10 P16435,Q92896,O75844,Q9NX62 4 +Negative regulation of protein secretion 0.7896458131651253 2.610596269455617 0.0090384528363558 1.0 0.4042370074976303 10 Q16850,P04035,Q8N5M9,P40939 4 +Positive regulation of macroautophagy 0.660483440587286 2.600087321757918 0.0093200041392031 1.0 0.4042370074976303 19 P12235,P09601,Q9Y371,P21796,O15269,Q6UWE0,O60858 7 +Respiratory chain complex iv assembly 0.8745947998490327 2.5980847635299753 0.0093745349695755 1.0 0.4042370074976303 7 Q8N8Q8,Q7KZN9,Q15070,Q9Y2R0,O43819 5 +Tetrapyrrole metabolic process 0.6597849609815902 2.5957101943911267 0.0094395646003113 1.0 0.4042370074976303 19 P22830,P09601,P30519,Q7KZN9,Q9NP58,O00264,Q9P0S9 7 +Regulation of mitochondrion organization 0.556071490754016 2.5759667339533445 0.0099960262867311 1.0 0.4042370074976303 45 O60313,Q8IXI1,P02545,Q9UG56,Q8N2A8,Q9H3K2,Q9NX47,O00165,P04637,P30536,P21796,Q96A26,Q969V5,P12235,O14737 15 +Regulation of mitochondrial membrane permeability 0.6928967594608664 2.5759280505033733 0.0099971446519837 1.0 0.4042370074976303 15 Q8IXI1,P52789,P04637,P45880,Q969V5,P12235 6 +Regulation of release of cytochrome c from mitochondria 0.7979489654594153 2.565837041368826 0.0102927171173083 1.0 0.4042370074976303 9 P02545,Q9H3K2,P04637,Q96A26,O14737 5 +Endoplasmic reticulum membrane organization 0.7946310301998888 2.54955717049442 0.0107859824895439 1.0 0.4042370074976303 9 Q8NHH9,Q15363,Q9NQC3,Q9P2W9,Q15041,Q12981 6 +Aerobic respiration 0.4866358735262533 2.540772413155525 0.0110607891315928 1.0 0.4042370074976303 91 O14949,Q9BSK2,P06576,P20674,P56385,Q7KZN9,Q9UDW1,P09622,P22695,P03886,O43676,O95139,P14406,O14548,P24539,P08574,O75323,P00403,Q13423,Q04656,Q9H3K2,P13073,O95168,Q15070,O95299,O96000,O75964,Q9Y6M9,O75208,P21912,P51970 31 +Vacuolar acidification 0.8245813451147527 2.527418502020762 0.0114904488860321 1.0 0.4042370074976303 8 Q8N511,P50897,Q93050,O75503,Q9Y487 5 +Ion transmembrane transport 0.548605310084042 2.5239851167089853 0.0116032841032058 1.0 0.4042370074976303 158 P06576,Q96AQ8,O00400,P20674,Q8NE86,Q9Y289,Q9HC21,P56385,Q14728,Q9C0H2,P05141,Q9H2D1,Q7KZN9,P20020,Q9UDW1,P55011,Q4KMQ2,Q9NW15,P53007,P05023,Q9UM00,Q8TDW0,P16615,Q12959,Q96PU5,P98194,O14548,P24539,P08574,Q8TB61,P23634,P45880,O75323,P00403,P05067,P21796,Q96ES6,P27105,Q6P4A7,Q13423,Q9UHG3,P51798,P35670,Q6KCM7,O95202,O75844,Q04656,P0CG08,Q99623,Q70HW3,P13073,Q9Y277,Q9BQT8,Q15043,P30825,Q6P4Q7,O75964,Q15041,Q9BPX6,P54709,P51790,O60831,P12236,Q9UJS0,Q9H9B4,O75746,Q9UBX3,P04920,Q9HD20,O43808,Q9NP58,Q9NUT2,P12235,P11413,O75915,Q9Y619 76 +Chloride transport 0.7193566227732686 2.520366288464528 0.0117232769341109 1.0 0.4042370074976303 13 Q9C0H2,P30536,P51798,Q9NW15,P55011,Q96S66,Q9UHG3,P51790 8 +Amino acid transmembrane transport 0.7174876654084635 2.510049667903119 0.0120714181537981 1.0 0.4042370074976303 13 O60831,Q9UJS0,O75746,P30825,Q15041,Q8TDW0,O75915,Q9Y619 8 +Copper ion homeostasis 0.854772394233503 2.5091296294034997 0.0121029060822452 1.0 0.4042370074976303 7 Q9NP58,P05067,O43819,P35670,Q04656 5 +Cellular copper ion homeostasis 0.854772394233503 2.5091296294034997 0.0121029060822452 1.0 0.4042370074976303 7 Q9NP58,P05067,O43819,P35670,Q04656 5 +Inorganic anion transport 0.596720231414727 2.50297223949478 0.0123155203546529 1.0 0.4042370074976303 28 P0CG08,O43681,Q9UHG3,Q9UBX3,Q9C0H2,P45880,P30536,Q9Y277,Q15043,P04920,Q9NW15,P21796,P55011,Q4KMQ2,Q96S66,P51798,P51790 17 +Transmembrane transport 0.5867145384940613 2.4973266110455565 0.0125133643553896 1.0 0.4042370074976303 216 Q9BSK2,P20674,Q9C0H2,P05141,Q9H2D1,Q9NS69,P20020,Q9UDW1,P55011,Q4KMQ2,Q9UM00,Q8TDW0,Q12959,O60830,Q9P2B4,Q9NRK6,P24539,P08574,P23634,P45880,P21796,Q6P4A7,Q13423,Q9UHG3,P35670,O95202,O75844,Q70HW3,P13073,Q99442,Q9Y277,P30825,P04062,O75964,P54709,Q9H9B4,Q9UBX3,Q9HD20,O43808,P31751,P16260,P11413,Q3ZCQ8,L0R6Q1,O00400,Q8NE86,Q9Y289,P38435,Q7KZN9,P16615,Q8WTV0,Q96PU5,O14548,Q8TB61,P27105,P51798,Q6KCM7,Q99623,Q9BQT8,Q15043,Q15041,P51790,O60831,Q9UJS0,O75381,Q9Y619,P52789,Q99797,Q9NW15,Q07820,P05023,O14925,P98194,Q6NUK1,Q96H78,P00403,P05067,P39210,Q96ES6,Q9H2V7,Q04656,P0CG08,Q6P4Q7,O75298,P23786,P12236,P49755,Q9NUT2,Q9NP58,Q7L0J3,P12235,Q96AQ8,P06576,Q9HC21,P56385,Q14728,O43615,P53007,Q03519,O75323,P50416,O96008,Q8NE01,O95831,Q15388,Q03518,Q9BPX6,O75746,P04920,O75915 110 +Import across plasma membrane 0.6341119472914157 2.493200527009666 0.0126597326887658 1.0 0.4042370074976303 20 P33121,Q9Y289,P23634,O75915,Q15043,P30825,P55011,P31751,P05023,Q15041,Q8TDW0,P54709,Q12959 13 +Lipoprotein metabolic process 0.641841315948311 2.482454780623312 0.0130480627560898 1.0 0.4042370074976303 19 P50897,Q16739,Q5HYI8,P04062,Q5H8A4,Q8N2K0,Q9NUJ1,Q92643 8 +Antigen processing and presentation 0.6006832832120499 2.478581609454731 0.0131905931808766 1.0 0.4042370074976303 24 P61026,Q03519,Q6P179,Q9UIQ6,Q9NZ08,Q03518,P10321,P04062,Q9BZG1,O00203 10 +Protein transmembrane import into intracellular organelle 0.7461642214462749 2.4773098128038984 0.0132376938583926 1.0 0.4042370074976303 11 O60830,O14925,O95831,Q15388,O43615,O96008,O75381 7 +Glycerolipid biosynthetic process 0.5199843483377403 2.4747675605481865 0.0133322914410134 1.0 0.4042370074976303 51 Q9NX62,P35790,Q96N66,Q10713,O14735,Q92604,Q92643,O95674,Q8WTV0,Q9NUQ2,P48651,Q9BVG9,Q01968,P33121,Q6IAN0,Q96PE3,Q9NTJ5,Q9UG56,Q9BTU6,Q9H490,Q9HCL2,Q9NPH0,Q96S52,Q6UWP7,O15228,Q5H8A4,Q8NF37 27 +Mitochondrial fusion 0.6653925335018344 2.4635306026464825 0.013757615047317 1.0 0.4042370074976303 16 Q99536,O60313,Q8IWA4,Q9UJZ1,Q8N2A8,O95140,Q8TB36,Q8NAN2,Q9Y3D6,Q969V5,Q9NX63,Q9Y6C9 12 +Steroid biosynthetic process 0.534646821948713 2.460327442198849 0.0138810305578336 1.0 0.4042370074976303 47 Q15392,P30536,Q15800,P05023,P28288,O75477,Q9BZF3,Q13510,Q16850,Q9UBM7,P16435,Q8NBQ5,Q53GQ0,Q14534,Q9UKR5,Q15125,Q14739,P37268,O94905,P04035,P11413,P14324 22 +Organelle fusion 0.5382406722491274 2.4583393476193955 0.0139581211356938 1.0 0.4042370074976303 46 Q86Y82,Q99536,O60313,Q9Y3E7,Q9Y4W6,Q9Y3D6,Q8NAN2,Q9Y6C9,Q8N2A8,Q9UNK0,O95249,Q12981,O60499,Q8TB36,O15400,Q969V5,Q9NX63,Q8IWA4,Q9UJZ1,O95140,O75396,Q9BZG1,P31751 23 +Chondrocyte differentiation 0.7241104754008953 2.4523168163747604 0.014193962919919 1.0 0.4042370074976303 12 Q92896,Q9NX62,Q92543,Q15043 4 +Protein insertion into mitochondrial inner membrane 0.9183083671358008 2.448675635314071 0.0143382505748905 1.0 0.4042370074976303 5 Q9Y5J9,Q9Y5J6,Q53H12 3 +Mitochondrial cytochrome c oxidase assembly 0.8721717074157269 2.4375901529067945 0.0147855268909378 1.0 0.4042370074976303 6 Q8N8Q8,Q9Y2R0,O43819,Q15070 4 +Endoplasmic reticulum calcium ion homeostasis 0.7715455198870262 2.435375720854489 0.0148763338881936 1.0 0.4042370074976303 9 P51572,P05067,Q96A33,Q9UM00,P16615,O76024 6 +Ceramide catabolic process 0.8693030085277879 2.425065932880369 0.0153056067476942 1.0 0.4042370074976303 6 P04062,Q13510,P06280,P17900 4 +Lipid localization 0.4600153202415432 2.4225955345472174 0.0154100732908801 1.0 0.4042370074976303 77 P35790,Q96AA3,P30536,Q9H6V9,Q8WTV0,O95674,P07602,P17900,Q9H2V7,O15118,Q16739,Q14534,P04062,P61916,Q7Z3C6,Q99720,Q14108,P23786,Q9NZJ7,Q9BUR5 20 +Nucleotide transport 0.6645927100245457 2.4092625555298257 0.0159847937516466 1.0 0.4042370074976303 15 Q9BSK2,P12236,O00400,Q6NUK1,Q9HC21,Q8TB61,P05141,Q9H2D1,P12235,Q08722,Q8TDW0,Q6KCM7 12 +Mitochondrial calcium ion homeostasis 0.6989140036729431 2.4068099423181533 0.0160925422631059 1.0 0.4042370074976303 13 Q8NEN9,Q8NE86,P51572,Q9Y4W6,Q16891,Q8WWC4,Q9Y3D6,Q9BPX6,Q96AQ8,O95202 10 +Transition metal ion transport 0.698662996019438 2.405405813959056 0.0161545155530236 1.0 0.4042370074976303 13 P98194,Q9HD20,Q15043,O15173,P35670,Q04656 6 +Amino acid transport 0.6205580321465131 2.4049593524616317 0.016174264698481 1.0 0.4042370074976303 20 O60831,Q96H78,Q9UJS0,O75746,Q7L0J3,P30825,P55011,Q6P4A7,Q15041,Q8TDW0,O75915,Q9Y619 12 +Mammary gland development 0.5910675112142825 2.400738107913019 0.0163620419563426 1.0 0.4042370074976303 23 P52789,Q99623,Q13505,P00403,Q9NQC3,P35670 6 +Water homeostasis 0.7642071509727099 2.398744174692152 0.0164514039194434 1.0 0.4042370074976303 9 P04062,Q96PU5,Q16739 3 +L alpha amino acid transmembrane transport 0.7451420414471933 2.384639758631028 0.0170958529679783 1.0 0.4042370074976303 10 O60831,Q9UJS0,O75746,P30825,Q15041,Q9Y619 6 +Regulation of macroautophagy 0.4965024419782621 2.379246748324774 0.0173480590366368 1.0 0.4042370074976303 54 Q15382,P04632,P09601,Q93050,P12235,P04637,P05141,Q9Y371,O60858,P04062,P21796,Q9NRR5,O15269,Q9Y487,Q6UWE0,Q9UNH7,Q9Y5X3,O15118 18 +Sensory perception of light stimulus 0.6510236926469387 2.376616485659085 0.017472243689584 1.0 0.4042370074976303 16 O60313,P50897,Q99797,Q6P4Q7,Q92696,Q9H6K4,O76024 7 +Protein import into mitochondrial matrix 0.7919794419135892 2.3726099776866016 0.0176629039420117 1.0 0.4042370074976303 8 O60830,O14925,Q15388,O43615,O96008 5 +Mitochondrial genome maintenance 0.7589817054814978 2.3725603794973584 0.0176652755845254 1.0 0.4042370074976303 9 P49916,Q9BSK2,O60313,P04637,P39210,P12235 6 +Sphingoid metabolic process 0.8995686876805511 2.37096644806677 0.0177416415510611 1.0 0.4042370074976303 5 P04062,Q13510,Q06136 3 +Inorganic anion transmembrane transport 0.7424478355652099 2.370758639972755 0.0177516190163924 1.0 0.4042370074976303 10 Q9BXP2,Q9Y289,Q9UBX3,P51798,P55011,Q4KMQ2,Q9UHG3,P51790,Q00325 9 +Amyloid precursor protein metabolic process 0.6149536328416858 2.368196097270039 0.0178750588299274 1.0 0.4042370074976303 20 O95197,O75298,Q16799,Q15392,P49755,Q92542,Q9NQC3,Q9NQX7 8 +Protein localization to vacuole 0.6050910621383281 2.3642432374244624 0.0180669461820017 1.0 0.4062192257648044 21 Q9Y371,Q9NQC3,P13473,Q14108,Q96RL7 5 +Regulation of steroid biosynthetic process 0.7383672234597958 2.3496900513514114 0.0187890494704443 1.0 0.4083313833108581 10 P16435,P30536,O94905,Q13510,P05023,Q9UBM7 6 +Phospholipid biosynthetic process 0.4586772267456314 2.3330145497419035 0.0196473816922497 1.0 0.410886910575985 61 Q9NX62,P35790,Q96N66,O15269,Q10713,O14735,Q92604,Q92643,O95674,P53602,Q9NUQ2,P48651,Q9BVG9,Q01968,Q6IAN0,Q96PE3,Q9NTJ5,Q9UG56,Q86YN1,Q9BTU6,Q9H490,Q9HCL2,Q9NPH0,Q96S52,Q6UWP7,O15228,Q5H8A4,P14324,Q8NF37 29 +Aminoglycan metabolic process 0.6353041345538054 2.330745336834317 0.0197667920419521 1.0 0.410886910575985 17 P16278,Q8N6G5,Q8NCH0,Q9NX62,P54802,Q96L58,Q7LGA3,P06865 8 +Cellular respiration 0.482609251372333 2.32797142488277 0.019913621049074 1.0 0.410886910575985 106 O14949,Q9BSK2,P06576,P20674,P56385,Q7KZN9,Q9UDW1,P09622,O43819,P03886,P22695,O43676,O95139,P14406,O14548,P24539,P08574,O75323,P00403,Q99643,Q13423,Q6KCM7,Q04656,Q16134,Q9H3K2,P13073,O95168,Q15070,O95299,P04062,O96000,O75964,Q9Y6M9,O75208,P21912,Q9UJS0,O75746,P51970 38 +L amino acid transport 0.7173734577211711 2.3252388610080628 0.020059191456655 1.0 0.410886910575985 11 O60831,Q9UJS0,O75746,P30825,Q15041,O75915,Q9Y619 7 +Adult behavior 0.6423025421062529 2.323415463138731 0.0201568442126094 1.0 0.410886910575985 16 O75844,P50897,Q92542,P51790,O15118 5 +Proteoglycan metabolic process 0.732764074078901 2.3206730956885893 0.0203044938371117 1.0 0.410886910575985 10 Q8N6G5,Q8NCH0,Q9NX62 3 +Glycosylceramide metabolic process 0.8857581104217436 2.3132453524059957 0.0207091533592036 1.0 0.4164339259287508 5 P04062,Q16739,Q16880 3 +Er nucleus signaling pathway 0.682258233569592 2.3131171845444047 0.0207161971443137 1.0 0.4164339259287508 13 Q15363,P57088,P04637,O94905,Q96A33,P16615,O76024 7 +Regulation of oxidoreductase activity 0.640343669964269 2.3114189725447 0.0208097239930935 1.0 0.4170268688215948 16 P16435,Q9BQ95,Q99623,P04899,P23634,P06280,Q15070,Q9P0J1,Q8TCT9,Q04656,Q8WTV0 11 +Endoplasmic reticulum unfolded protein response 0.5969959129435108 2.3097126671828954 0.0209040670494533 1.0 0.4176324806536494 21 Q96HY6,Q15363,Q96HE7,Q9BUN8,P57088,Q9Y4P3,Q6NTF9,Q7Z2K6,Q92905,Q9GZP9,O76024 11 +Negative regulation of secretion 0.6057320800928638 2.307350000848105 0.0210353161774219 1.0 0.4189694625796608 20 P09601,P04035,Q16850,P40939,Q8N5M9 5 +Endoplasmic reticulum to golgi vesicle mediated transport 0.4507340940169446 2.3027689368166113 0.0212918471512488 1.0 0.4227859771222071 62 Q9Y6Y8,O15498,Q15363,Q96PC5,Q9NR31,Q9Y296,Q9P2W9,Q9Y3B3,O95070,P24390,Q9HCU5,O95249,Q9Y282,Q8NHH9,P62820,Q5JRA6,P61019,Q9BVK6,P49755,P51572,O75396,Q9H0U4,Q969X5 23 +Atp transport 0.8083385189794707 2.296952196593863 0.0216214968810244 1.0 0.4267297248064005 7 P12236,Q6NUK1,P05141,P12235,Q08722,Q6KCM7 6 +Dicarboxylic acid transport 0.6373525710953576 2.2930676213982273 0.021844112143514 1.0 0.4272476917954475 16 O60831,Q9UJS0,O75746,Q9BQT8,Q9UBX3,Q9H2D1,P55011,Q15041,O75915 9 +Protein localization to endoplasmic reticulum 0.557076111067312 2.2912830756145977 0.0219470468116009 1.0 0.4272476917954475 33 P61026,Q5JRA6,Q96HY6,P46379,O43681,P24390,Q9UGP8,Q9Y5M8,P51572,Q99442,O15258,Q9NQC3,Q7L5D6,Q15005 14 +Cellular homeostasis 0.5143835926342594 2.2752700500093157 0.0228897349362351 1.0 0.4272476917954475 145 P06576,Q8NE86,P52789,Q96HE7,Q9NQC3,Q9Y3D6,P20020,Q07820,P55011,Q4KMQ2,O43819,O75787,P05023,Q9UM00,P09622,P16615,Q96PU5,P50897,P98194,P09601,P04920,P23634,Q16891,P54105,P05067,P14735,P35670,Q04656,O95202,O76024,P0CG08,P61421,Q15043,Q8WWC4,Q6ZWJ1,O75503,Q9BWH2,Q9BPX6,Q96TC7,P54709,P51790,Q8N5M9,Q8IXI1,Q8N511,Q93050,Q9NWS0,Q9UJZ1,Q05086,Q9Y263,P51572,Q15904,Q9HD20,Q9NUT2,Q9NP58,Q7L0J3,Q96A33,P10253,O75880,Q9Y487,P13473,Q96AQ8,O00203 62 +Glycolipid catabolic process 0.8352653706627527 2.27503786133358 0.0229036586887301 1.0 0.4272476917954475 6 P04062,P06280,P17900 3 +Response to endoplasmic reticulum stress 0.4554423246172138 2.2746752392183915 0.0229254189144505 1.0 0.4272476917954475 85 O60313,Q15363,P46379,Q96HE7,P57088,Q7Z2K6,Q9UM00,Q92905,Q9UBV2,Q9GZP9,P16615,O75477,Q9BUN8,Q9Y4P3,O14656,Q7L5D6,Q96CS3,O76024,O95831,Q8IXB1,Q4ZIN3,O43765,P27824,Q8TCT9,O60858,Q13144,Q96HY6,Q9UNE7,P04637,P51572,Q9H3N1,O94905,Q96A33,O75955,Q04323,Q6NTF9 36 +Positive regulation of cysteine type endopeptidase activity 0.570095293885992 2.273415860827653 0.0230011312332287 1.0 0.4272476917954475 25 Q9P0J0,O95831,P51572,Q9NZJ7,Q96A26,Q969V5,O14737 7 +Regulation of mitochondrial membrane permeability involved in apoptotic process 0.7075006920869967 2.2724423842087553 0.023059804207749 1.0 0.4272476917954475 11 Q8IXI1,P04637,Q969V5,P45880 4 +Protein insertion into er membrane 0.7387153388468715 2.2702216162226736 0.0231941401009392 1.0 0.4272476917954475 9 P46379,O43681,Q15006,Q96A33,Q9NPA0,Q7L5D6 6 +Iron ion homeostasis 0.6244188594992787 2.2626700244180324 0.0236560379698 1.0 0.4327858856665955 17 Q8N511,P09601,P30519,Q15904,Q15043,Q9Y487 6 +Glycolipid biosynthetic process 0.688482535634559 2.2575695655814743 0.0239725078712911 1.0 0.4373471814165801 12 Q16880,Q16739,Q8NBX0,Q5H8A4 4 +Respiratory chain complex iii assembly 0.828700747249226 2.2457993761156283 0.0247168612999186 1.0 0.4442434493556871 6 Q9BSK2 1 +Glycerophospholipid biosynthetic process 0.5130305346342175 2.241769369075948 0.0249762818846683 1.0 0.4442434493556871 46 Q9NX62,P35790,Q96N66,Q10713,O14735,Q92643,O95674,Q9NUQ2,P48651,Q9BVG9,Q01968,Q6IAN0,Q96PE3,Q9NTJ5,Q9UG56,Q9BTU6,Q9H490,Q9HCL2,Q9NPH0,Q96S52,Q6UWP7,O15228,Q5H8A4,Q8NF37 24 +Regulation of mammary gland epithelial cell proliferation 0.8681071568202763 2.238914397413549 0.0251614865165121 1.0 0.4442434493556871 5 Q9NQC3 1 +Cellular iron ion homeostasis 0.6524595041220235 2.236258724696938 0.0253348284771384 1.0 0.4442434493556871 14 Q8N511,P09601,Q15904,Q15043,Q9Y487 5 +Regulation of lysosomal lumen ph 0.8657535276176926 2.2289555045000453 0.0258168654850976 1.0 0.4442434493556871 5 Q8N511,P50897,O75503 3 +Sodium ion homeostasis 0.7936312330425551 2.2286245453220843 0.025838896499722 1.0 0.4442434493556871 7 Q96PU5,P55011,P05023,Q9Y5X3,P54709 5 +Vitamin transmembrane transport 0.793153963424141 2.226398130587683 0.0259875255956574 1.0 0.4442434493556871 7 Q8WTV0,P04062,P38435,Q9H2D1 4 +Vitamin transport 0.793153963424141 2.226398130587683 0.0259875255956574 1.0 0.4442434493556871 7 Q8WTV0,P04062,P38435,Q9H2D1 4 +Regulation of water loss via skin 0.864464740595478 2.2234975492363955 0.0261822684609509 1.0 0.4448330588689281 5 Q16739 1 +Organic acid transport 0.5022942655205876 2.21028618797214 0.0270853065901937 1.0 0.4525328341709726 48 Q9Y289,Q9H2D1,Q9Y3D6,P55011,P53007,Q8TDW0,Q96H78,P28288,P50416,Q6P4A7,P33121,Q9BQT8,P30825,Q15041,P23786,O60831,Q9UJS0,Q9H9B4,O75746,Q9UBX3,O43808,Q7L0J3,P31751,O75915,Q9Y619 25 +Glycerolipid metabolic process 0.4347609896666918 2.2083046502647345 0.0272230433877609 1.0 0.4525328341709726 72 Q9NX62,P35790,Q96N66,Q10713,P40939,Q9UBV2,Q92604,Q92643,O95674,Q8WTV0,Q9NUQ2,P50416,P48651,Q9BVG9,Q01968,P33121,Q99623,Q6IAN0,Q8NCG7,Q96PE3,Q9NTJ5,Q8N2K0,Q9UG56,Q8IY17,Q9UJZ1,Q9BTU6,Q9H490,Q9HCL2,Q9NPH0,Q96S52,Q53H12,O15228,Q5H8A4,Q8NF37 34 +Positive regulation of necrotic cell death 0.819842481128996 2.2061893106787354 0.0273707474056492 1.0 0.4525328341709726 6 P04637,Q7Z3C6,P00403 3 +Amyloid precursor protein catabolic process 0.6231229262605417 2.205210559832519 0.0274393225273361 1.0 0.4525328341709726 16 O95197,Q15392,P49755,Q92542,Q9NQC3,O75298 6 +Inorganic ion import across plasma membrane 0.7566236064846579 2.2014220963991624 0.0277061561480898 1.0 0.4525328341709726 8 P23634,Q15043,P55011,P05023,P54709,Q12959 6 +L glutamate transmembrane transport 0.8176845972576249 2.196513149017876 0.0280552350619114 1.0 0.4525328341709726 6 O75746,O60831,Q15041,Q9UJS0 4 +Amine transport 0.7556058218182018 2.1964428451958935 0.028060261828823 1.0 0.4525328341709726 8 Q15041,O75915,O14656,Q7L0J3 4 +Peptide catabolic process 0.6765955213312784 2.191569554144297 0.02841060234591 1.0 0.4525328341709726 12 Q6P179,Q9UIQ6,Q9NZ08,P42892,P09960,P55786,Q9UJ14,O14773 8 +Membrane organization 0.5591377719004945 2.1870291372240596 0.0287403970039534 1.0 0.4525328341709726 218 Q86Y82,O15498,Q9NVH1,P05141,Q9NR31,Q86XL3,Q9NQC3,Q9NS69,Q9P2W9,Q4KMQ2,P50897,P45880,Q13505,O95249,O15118,O95202,O75844,P02545,Q16739,O43760,O60499,Q8N8Q8,Q9Y371,Q15070,Q5XKP0,Q9NZJ7,Q9BUR5,Q96A33,Q15363,Q15392,Q9H6H4,P16615,Q9Y5J9,Q6UXV4,Q9NPA0,O14737,Q9Y5J6,Q8NHH9,Q9H3K2,P49354,Q969V5,Q15041,P51790,Q8IXI1,Q96CP7,Q8IWA4,Q53H12,Q9P0J0,P52789,O43681,P57088,Q96AA3,P98194,P50402,Q9Y512,Q16891,Q12981,Q5JRA6,P20700,O15400,P61916,Q7Z3C6,Q9NX63,O75431,Q9BVK6,Q00765,P49755,P04637,O75955,P12235,O15258,O00203,O60313,Q9UH99,P46379,P30536,Q15006,O14656,O95140,Q9BZG1 80 +Import into cell 0.5526921368426112 2.1819912585497354 0.0291101778819358 1.0 0.4525328341709726 28 Q6UWE0,Q9Y289,P23634,O75915,O14656,Q15043,P30825,P55011,P31751,O75955,P05023,Q15041,Q8TDW0,P54709,Q12959 15 +Sterol biosynthetic process 0.5524592204951324 2.180260815338523 0.0292381338963869 1.0 0.4525328341709726 28 P16435,Q15392,P37268,Q14534,O94905,P04035,Q15800,Q16850,Q15125,Q9UBM7,Q14739 11 +Regulation of leukocyte degranulation 0.7510118301341292 2.1739321337937993 0.0297102323562659 1.0 0.4525328341709726 8 P09601 1 +Carboxylic acid transport 0.5341795674601731 2.169058444501552 0.0300782470673846 1.0 0.4525328341709726 36 Q9Y289,Q9H2D1,P55011,P53007,Q8TDW0,P07602,P28288,Q9BQT8,P30825,Q15041,O60831,Q9UJS0,Q9H9B4,O75746,Q9UBX3,Q9NZJ7,Q7L0J3,O75915,Q9Y619 19 +Lactation 0.6720390519190012 2.166133907902386 0.0303009557793692 1.0 0.4525328341709726 12 P35670,Q13505,P52789,P00403 4 +Amyloid beta formation 0.6876187012617552 2.165104007281371 0.0303797211678431 1.0 0.4525328341709726 11 O95197,P49755,Q92542,Q9NQC3,O75298 5 +Positive regulation of peptidase activity 0.5258032200068005 2.164806238535875 0.0304025268673318 1.0 0.4525328341709726 39 Q9P0J0,Q96HY6,O95831,Q9UL46,P61289,P51572,Q92542,Q9NZJ7,P05067,Q96A26,Q969V5,O14737 12 +Regulation of necrotic cell death 0.6855548602725885 2.153883783652725 0.0312492869896183 1.0 0.4525328341709726 11 P04637,P00403,Q13510,Q7Z3C6,P12235 5 +Positive regulation of mitochondrion organization 0.5559687163886194 2.152153255494514 0.0313852858713092 1.0 0.4525328341709726 23 Q8N2A8,Q9NX47,P04637,P21796,Q969V5,Q96A26,O14737 7 +Ceramide transport 0.7769163692643135 2.150310581569468 0.0315306559550927 1.0 0.4525328341709726 7 P07602 1 +Antigen processing and presentation of endogenous peptide antigen 0.7460054324723154 2.1493339123774824 0.0316079401092823 1.0 0.4525328341709726 8 Q03519,Q6P179,Q9NZ08,P04439,Q03518,P10321 6 +Antigen processing and presentation of endogenous antigen 0.7460054324723154 2.1493339123774824 0.0316079401092823 1.0 0.4525328341709726 8 Q03519,Q6P179,Q9NZ08,P04439,Q03518,P10321 6 +Tail anchored membrane protein insertion into er membrane 0.7760555475915996 2.146258394349096 0.0318523690275163 1.0 0.4525328341709726 7 P46379,O43681,Q15006,Q9NPA0,Q7L5D6 5 +Phosphatidylglycerol metabolic process 0.6684366391197798 2.1459703293360337 0.0318753459749365 1.0 0.4525328341709726 12 O95674,Q99623,Q9HCL2,P40939,Q8NF37 5 +Atp synthesis coupled proton transport 0.6840153580238731 2.145504597684733 0.0319125242155893 1.0 0.4525328341709726 11 P06576,O75964,P24539 3 +Regulation of autophagy 0.4511980602549258 2.14406928685892 0.0320273355430875 1.0 0.4525328341709726 92 P30536,Q07820,O15269,P10619,Q6UWE0,Q9Y5X3,P07602,P09601,Q86UE4,P21796,Q9NRR5,O15118,O75844,Q9Y371,P04062,O60858,Q93050,O00165,P04637,Q9NZJ7,Q9Y487,P12235 22 +Selective autophagy 0.5492006971663284 2.1437808254708064 0.0320504524113047 1.0 0.4525328341709726 27 Q96HY6,P12235,Q99623,O95140,Q9Y6I9,P04637,P05141,P21796,O15269,Q6UWE0 10 +Mitochondrial electron transport ubiquinol to cytochrome c 0.8452724824820634 2.141824624717392 0.0322075970961799 1.0 0.4525328341709726 5 O14949 1 +Negative regulation of mitochondrion organization 0.6202593512797928 2.1412800957564393 0.0322514572638119 1.0 0.4525328341709726 15 O60313,P02545,Q9H3K2,P04637,P30536,Q969V5 6 +Triglyceride metabolic process 0.6675543968035861 2.1410249623228332 0.0322720250949113 1.0 0.4525328341709726 12 Q9HCL2,Q96N66,Q8NCG7,Q9UBV2,Q92604,Q8WTV0 6 +Sodium ion transmembrane transport 0.572269256746578 2.1409277057099 0.0322798684900722 1.0 0.4525328341709726 21 Q96PU5,P23634,Q6P4Q7,P55011,Q4KMQ2,P27105,P05023,Q12959 8 +Mitochondrial electron transport cytochrome c to oxygen 0.8052965129082634 2.140758547186053 0.0322935144061959 1.0 0.4525328341709726 6 Q7KZN9,P13073,O14548,P00403 4 +Lipoprotein biosynthetic process 0.6340005145023329 2.126924110962875 0.0334263891651036 1.0 0.46023878116751 14 Q5HYI8,P04062,Q16739,Q5H8A4 4 +Glycosylation 0.4928121743247363 2.1253354277424923 0.033558634118221 1.0 0.46023878116751 48 Q16706,Q8N4A0,Q86YN1,Q9BT22,Q96AA3,Q96L58,P04062,O75503,Q10472,P04843,P46977,O15118,Q2TAA5 13 +Proteoglycan biosynthetic process 0.7085641145371269 2.1156346364893084 0.0343758936469109 1.0 0.4699100805493295 9 Q8N6G5,Q7LGA3,Q8NCH0,Q96L58 4 +Alcohol biosynthetic process 0.5247763791325959 2.1137201584919385 0.0345391757188764 1.0 0.4699100805493295 37 P16435,Q15392,P37268,O94905,P04062,P04035,Q13510,O15269,Q15800,Q16850,Q15125,Q9UBM7,Q14739 13 +Amyloid beta metabolic process 0.6473968708025504 2.1135559799637655 0.0345532089775182 1.0 0.4699100805493295 13 O95197,P49755,Q92542,Q9NQC3,O75298 5 +Toll like receptor signaling pathway 0.6156034869485953 2.1126377096334337 0.0346317885250542 1.0 0.4699100805493295 15 Q9NQC3,Q5KU26,P51812,Q9UBC1,Q9NPR9,O75955,Q14254,O00203 8 +Positive regulation of membrane permeability 0.6618817903597153 2.1091593498815415 0.0349308293834114 1.0 0.4720010202783372 12 Q8IXI1,P04637,Q969V5,P45880 4 +Mitochondrial calcium ion transmembrane transport 0.6918528138321727 2.105722096225383 0.0352284993019202 1.0 0.4750377141892482 10 Q8NE86,Q9UJZ1,Q9Y4W6,Q8WWC4,P21796,Q9BPX6,Q96AQ8,O95202 8 +Midbrain development 0.5913999943182295 2.1025473194208395 0.0355053591081802 1.0 0.4755085602716934 18 O14949,P24539,Q16352,Q5T9L3 4 +Glycolipid transport 0.8358553999517059 2.101480598083308 0.0355987993886595 1.0 0.4755085602716934 5 P07602,Q96AA3,Q9NZJ7 3 +Cell recognition 0.5457095498095044 2.0963275448547347 0.0360531448980121 1.0 0.4759130822499844 25 P45880,Q9NQC3,Q5KU26,P35613,Q8WTV0 5 +Endochondral bone morphogenesis 0.765375832802723 2.0958308364726874 0.0360971998512962 1.0 0.4759130822499844 7 O75844,Q9NX62 2 +Phosphatidic acid metabolic process 0.7343391554472029 2.0917435453961257 0.03646146291297 1.0 0.4772943375130702 8 Q9HCL2,Q9NPH0,Q9NUQ2,O15228,Q8NF37 5 +Mitochondrial outer membrane permeabilization 0.6887141858822007 2.0890065811704694 0.0367071307542463 1.0 0.4781470852048131 10 Q8IXI1,Q969V5,P45880 3 +Leukocyte differentiation 0.416953880237016 2.0868999235070333 0.0368971818196619 1.0 0.478707858947128 66 P0CG08,P24390,O00165,P04637,Q15904,Q5HYI8,P05067,P55327,P04062,O96005,O00625,Q14739,Q04656,Q8N5M9 14 +Adult locomotory behavior 0.6421738151716552 2.0832510380932754 0.037228347123468 1.0 0.4810877476491014 13 O75844,P50897,P51790,O15118 4 +Mitochondrial atp synthesis coupled proton transport 0.6856752996204846 2.072791712577571 0.0381916680442204 1.0 0.4867756046418942 10 P06576,O75964,P24539 3 +Hormone metabolic process 0.5371070612682874 2.0654388817617884 0.0388814928394871 1.0 0.4917965982216548 28 P16435,O75844,Q9HB40,Q9Y394,P42892,Q8NBN7,P30536,Q53GQ0,O75787,P05023,O95470 11 +Apoptotic mitochondrial changes 0.5314457255204769 2.0622866313919626 0.0391804550376275 1.0 0.491907727868005 31 Q8IXI1,P02545,P52789,Q9H3K2,P04637,P45880,Q96A26,Q969V5,P12235,O14737 10 +Granulocyte differentiation 0.7279336135374186 2.059962401920454 0.0394021353023885 1.0 0.4927639952669743 8 O00165,Q14739,Q8N5M9 3 +Tetrapyrrole biosynthetic process 0.6224478243104287 2.057780708916098 0.0396111887000938 1.0 0.4927639952669743 14 P22830,P30536,Q9NP58,Q7KZN9,O00264,Q9P0S9 6 +Regulation of leukocyte mediated cytotoxicity 0.7570218348379143 2.056186074841112 0.0397645839957512 1.0 0.4933080677415766 7 P04439,O15400,P11279 3 +Cellular response to chemical stress 0.421109003642761 2.0552505343872336 0.0398548123998552 1.0 0.4934874394681693 72 Q9BXW9,Q9NX61,P30536,P00374,Q07820,Q8TDW0,P16615,Q6NUK1,P09601,P23246,P39210,Q04656,O95202,O95831,P04062,Q8TED1,Q99720,Q9BPX6,P04637,Q15233,P11413,O75915 22 +Oligosaccharide metabolic process 0.8238683582180314 2.0498716317401153 0.040376959152792 1.0 0.494314163462659 5 P06280,P17900 2 +Cerebellar cortex development 0.6494056287688825 2.038660452356207 0.0414839273344707 1.0 0.4987033906698864 12 O14949,P04062,Q5KU26,P54802 4 +Maintenance of location 0.4114150551975981 2.0373969788541255 0.0416102763811931 1.0 0.4987033906698864 65 O95674,P52789,Q9UH99,P17900,P24390,P30536,Q14534,Q9H6V9,P10253,P04062,O95202,O15258,P35670,Q96RL7,Q8WTV0 15 +Glycerophospholipid metabolic process 0.4113697655909066 2.036881934637526 0.0416618748941552 1.0 0.4987033906698864 65 Q9NX62,P35790,Q96N66,Q10713,P40939,O14735,Q92604,Q92643,O95674,Q8WTV0,Q9NUQ2,P48651,Q9BVG9,Q01968,Q99623,Q6IAN0,Q96PE3,Q9NTJ5,Q8N2K0,Q9UG56,Q8IY17,Q9UJZ1,Q9BTU6,Q9H490,Q9HCL2,Q9NPH0,Q96S52,Q6UWP7,O15228,Q5H8A4,Q8NF37 31 +Chloride transmembrane transport 0.7823545150866957 2.036584820235869 0.0416916652433625 1.0 0.4987033906698864 6 P51790,Q9UHG3,P55011,P51798 4 +Autophagy of mitochondrion 0.526098783075506 2.035735086064345 0.0417769638931839 1.0 0.4987033906698864 32 P52789,Q99623,O95140,O00165,P04637,P30536,P04062,P21796,Q969V5,Q9BWH2,Q7Z3C6,P12235 12 +Skeletal system morphogenesis 0.5570234661150686 2.035174237948709 0.0418333442592362 1.0 0.4987033906698864 21 P16435,O75844,Q9NX62,Q92896,O95470 5 +Cation transport 0.498687288006182 2.0302579486962467 0.0423303262310248 1.0 0.5012680268048451 153 P06576,Q96AQ8,O00400,P20674,Q8NE86,Q9Y289,Q96HE7,Q9HC21,P56385,P05141,P30536,Q7KZN9,P20020,Q9UDW1,P55011,Q4KMQ2,Q9NW15,P05023,Q9UM00,O15173,P16615,Q12959,Q96PU5,P98194,O14548,P24539,P08574,O75323,P23634,O14656,P00403,P05067,P21796,Q96ES6,P27105,Q13423,P35670,Q6KCM7,O95202,O75844,O76024,Q04656,Q99623,Q70HW3,P13073,Q15043,P30825,Q6P4Q7,O75964,Q9UNH7,Q9BPX6,P54709,P51790,Q9H9B4,Q9HD20,O43808,Q9NP58,Q9NUT2,P12235,P11413,Q9Y619 61 +Atp metabolic process 0.4649706485493463 2.0255724838729376 0.0428086136454273 1.0 0.5041817372019316 116 O14949,Q9BSK2,P06576,P20674,P52789,P56385,Q9BRR6,P30536,Q7KZN9,Q9UDW1,P09622,P03886,P22695,O43676,O95139,P14406,O14548,P24539,P08574,O75323,P00403,Q99643,P05067,Q6KCM7,Q04656,Q9H3K2,P13073,O95168,O95299,O96000,O75964,Q9Y6M9,O75208,Q9UJS0,O75746,P04637,P51970 37 +Chemokine production 0.6762812964939048 2.0224773966670835 0.04312705641295 1.0 0.5051915798876679 10 Q969V5,P09601 2 +Outer mitochondrial membrane organization 0.817264332419848 2.021317511062215 0.0432469075953181 1.0 0.5056860128694919 5 Q9NS69,O14737 2 +Sterol metabolic process 0.4971473629671516 2.0201944805869285 0.0433632185797081 1.0 0.5061373523470236 43 P16435,Q15392,P37268,Q14534,O94905,P05067,P61916,P04062,P04035,Q15800,Q16850,Q15125,Q9UBM7,Q14739,O15118,Q8WTV0 16 +Regulation of oxidative phosphorylation 0.6751450538165235 2.016372253923665 0.043761064609616 1.0 0.5079952344709262 10 P14406,Q9BSK2,O14548 3 +Regulation of cysteine type endopeptidase activity 0.4840117140243475 2.0151666794011023 0.0438871875408473 1.0 0.5079952344709262 47 Q9P0J0,P16435,O95831,Q15041,Q9NWS0,Q15392,P51572,Q9NZJ7,P51812,Q96A26,Q969V5,Q15375,O14737,O75915 14 +Hormone biosynthetic process 0.7186308474017288 2.0136049491953134 0.0440510264109679 1.0 0.5079952344709262 8 P16435,P30536,Q53GQ0,P05023,Q9UBM7 5 +Regulation of amino acid transport 0.7763104831410546 2.008943022732306 0.0445431765976824 1.0 0.5089644020714139 6 Q15041,O75915,Q7L0J3 3 +Peroxisome organization 0.6588435885027821 2.0073404319933985 0.0447134268085887 1.0 0.5092597068269605 11 P40855,Q9Y3D6,O75381,P56589 4 +Protein localization to lysosome 0.612874694464217 2.0000673772270963 0.0454929888633226 1.0 0.5170957006401752 14 Q9NQC3,Q14108,P13473 3 +Regulation of biomineralization 0.7151825162394142 1.996360760421971 0.0458946687442978 1.0 0.5180450217185645 8 O75844,P20020,P04920 3 +Macroautophagy 0.4506880356803568 1.9878697493613733 0.046826097152983 1.0 0.5224536025722384 105 Q86Y82,Q9Y3E7,P05141,Q9UPT5,O15269,Q6UWE0,P51809,Q9Y5X3,P16615,Q5T8D3,P09601,P21796,Q9NRR5,O15118,Q15382,P04632,P62820,Q9H9H4,Q99623,P61421,Q9Y6I9,P36543,Q9Y371,P04062,Q7Z3C6,Q9UNH7,O14681,O60858,Q16543,Q96HY6,Q93050,Q9Y263,O95140,P04637,O75396,Q9H0U4,Q9Y5K8,Q9Y487,P13473,P12235 40 +Calcium import into the mitochondrion 0.7426882389545869 1.987760137291139 0.0468382243670388 1.0 0.5224536025722384 7 Q8NE86,Q9Y4W6,Q8WWC4,P21796,Q9BPX6,Q96AQ8 6 +Oligosaccharide lipid intermediate biosynthetic process 0.8095105398558003 1.987683063132352 0.0468467532476872 1.0 0.5224536025722384 5 Q86YN1,Q9BT22,Q96AA3 3 +Er overload response 0.8091762763710566 1.9862304584114807 0.0470077402941613 1.0 0.5229134040410716 5 Q96A33,P04637,O76024 3 +Body fluid secretion 0.6103934796992438 1.985047240095473 0.0471392159082886 1.0 0.5230284722498872 14 P35670,Q13505,P52789,P00403 4 +Protein catabolic process in the vacuole 0.712634403364103 1.9835973673004064 0.0473007429397618 1.0 0.5230386057159063 8 P04062,Q8N511,P13473,Q96RL7 4 +Lysosomal protein catabolic process 0.712634403364103 1.9835973673004064 0.0473007429397618 1.0 0.5230386057159063 8 P04062,Q8N511,P13473,Q96RL7 4 +T cell activation 0.4384001868173021 1.9785921337730412 0.0478619460242799 1.0 0.5240371963872464 58 P10644,P49366,P0CG08,Q9BXW9,P24390,P04439,P04637,O00203,Q9HCL2,Q92542,Q9NUQ9,Q5HYI8,P30825,P04062,O96005,Q08722,Q04656,Q12959 18 +Regulation of hormone metabolic process 0.8069038917537811 1.976349634438368 0.0481151916842581 1.0 0.5240371963872464 5 O75844,P05023 2 +Glycoside catabolic process 0.806563680353716 1.9748694592230007 0.0482829640542499 1.0 0.5247470148542691 5 P04062,Q9NUJ1,P06280 3 +Positive regulation of response to endoplasmic reticulum stress 0.7687192989421103 1.974109868174333 0.0483692515069282 1.0 0.5247470148542691 6 P57088,P51572,Q4ZIN3 3 +Cellular sodium ion homeostasis 0.8062823859472914 1.9736454478773615 0.048422072152221 1.0 0.5247470148542691 5 P05023,Q96PU5,P55011 3 +Mammary gland epithelial cell proliferation 0.7676271329948839 1.9690877756924512 0.0489430123610523 1.0 0.5286594213722563 6 Q9NQC3 1 +Golgi vesicle budding 0.8051766043522104 1.968832317012893 0.0489723498884728 1.0 0.5286594213722563 5 Q9BVK6,Q15363 2 +Organelle disassembly 0.4755170596908622 1.9683602086580976 0.0490266068645544 1.0 0.5286594213722563 48 Q96HY6,P52789,Q99623,O95140,Q9Y6I9,O00165,P04637,P30536,P04062,P21796,Q969V5,Q9BWH2,Q7Z3C6,P12235 14 +Regulation of mitophagy 0.7664282115300857 1.9635717468485427 0.049579776541955 1.0 0.532859875606853 6 P12235,P04637,P21796 3 +Diol biosynthetic process 0.7061673660069211 1.9511245250491356 0.0510422344382952 1.0 0.5343727561297256 8 P04062,Q13510 2 +Diol metabolic process 0.7061673660069211 1.9511245250491356 0.0510422344382952 1.0 0.5343727561297256 8 P04062,Q13510 2 +Release of cytochrome c from mitochondria 0.6036967245482426 1.9443816751037704 0.0518494419908772 1.0 0.5387681209830971 14 P02545,Q9H3K2,P04637,Q96A26,O14737 5 +Membrane protein ectodomain proteolysis 0.6757537630051417 1.9442387370830336 0.0518666684870876 1.0 0.5387681209830971 9 Q9NZ08,O43847,Q8TCT8,Q92542 4 +Cell volume homeostasis 0.7614307931570673 1.9405452732702664 0.0523134576767871 1.0 0.5407513847587003 6 Q9NUT2,P54105,P55011,Q4KMQ2,P51790 5 +Negative regulation of hormone secretion 0.7325871852244276 1.9392350160707683 0.0524727276473973 1.0 0.5407513847587003 7 P40939,Q8N5M9 2 +Negative regulation of peptide secretion 0.7325871852244276 1.9392350160707683 0.0524727276473973 1.0 0.5407513847587003 7 P40939,Q8N5M9 2 +Activation of cysteine type endopeptidase activity involved in apoptotic process 0.6314259016408229 1.9360622790725528 0.052860073729601 1.0 0.541082443938565 12 Q969V5,Q96A26,Q9NZJ7 3 +Atp biosynthetic process 0.5585675858463577 1.9358034071336152 0.0528917834783047 1.0 0.541082443938565 19 P06576,Q9UJS0,P56385,P24539,P00403,O75964 6 +Positive regulation of cell killing 0.758451603274725 1.9267919693308957 0.054005560700385 1.0 0.5470267758034341 6 P04439,O15400,P11279 3 +Positive regulation of mitochondrial calcium ion concentration 0.7580960958798807 1.925149483482696 0.054210659839305 1.0 0.5474015930750292 6 Q9BPX6,Q8NE86,Q96AQ8,P51572 4 +Vacuolar transport 0.4492068988769607 1.9237368018835637 0.0543875825877717 1.0 0.5483379650064357 54 Q96L92,P11279,P07602,Q96ED9,Q9NZJ7,P13473,Q14108,O15118,Q96RL7 9 +Regulation of body fluid levels 0.4602130943171192 1.9225623906666691 0.0545350310677663 1.0 0.5489747408722756 51 Q16739,P52789,P38435,Q13505,P00403,P04062,Q9UIJ7,Q9BWH2,P35670,Q04656,O76024 11 +Regulation of multicellular organism growth 0.6145488245354112 1.9212065147554545 0.0547056771781782 1.0 0.5493272849526628 13 O75844,O95470,Q9HCL2 3 +Antigen processing and presentation of peptide antigen via mhc class i 0.6143973275207705 1.9203097221442609 0.0548187890669928 1.0 0.5493272849526628 13 Q03519,Q6P179,Q9UIQ6,Q9NZ08,P04439,Q03518,P10321 7 +Secondary alcohol metabolic process 0.4762089836502579 1.915923564181928 0.0553748256061708 1.0 0.550617096186181 46 P16435,Q15392,P37268,Q14534,O94905,P05067,P61916,P04062,P04035,Q15800,Q16850,Q15125,Q9UBM7,Q14739,O15118,Q8WTV0 16 +Fatty acid transmembrane transport 0.7558875373028956 1.9149394842818088 0.0555002216257747 1.0 0.550617096186181 6 P31751,P23786,P28288,P50416 4 +Organic hydroxy compound biosynthetic process 0.444173157394778 1.9123049299462076 0.0558370938680692 1.0 0.5521272019338535 55 Q15392,P00374,O15269,Q15800,P28288,O75477,Q13510,Q16850,Q9UBM7,Q04656,P16435,Q14534,P04062,Q15125,Q14739,P37268,O94905,P04035,P11413,P14324 20 +Phagocytosis recognition 0.8985823524301102 1.9120835918945176 0.0558654730653169 1.0 0.5521272019338535 4 Q8WTV0 1 +T cell differentiation 0.5180733343241757 1.9102100213693771 0.0561061773722775 1.0 0.5528283407347103 27 P0CG08,P24390,P04637,Q5HYI8,P04062,O96005,Q04656 7 +Potassium ion import across plasma membrane 0.7532443305431904 1.9027061329869652 0.0570789012375729 1.0 0.558558922983059 6 P05023,P55011,P54709,Q12959 4 +Regulation of cell killing 0.6957936532734011 1.8987976478687991 0.0575910865900475 1.0 0.5599600314921966 8 P04439,O15400,P11279 3 +Negative regulation of response to cytokine stimulus 0.6671575760832005 1.8987909746274336 0.0575919643382014 1.0 0.5599600314921966 9 Q14166 1 +Sphingosine biosynthetic process 0.8947687246565822 1.8967580903682184 0.0578598729410506 1.0 0.5599600314921966 4 P04062,Q13510 2 +Mitochondrial outer membrane permeabilization involved in programmed cell death 0.6382844062517765 1.8928796189252448 0.0583738802175368 1.0 0.5628202716423423 11 Q969V5,P45880 2 +Protein n linked glycosylation 0.5595862441144596 1.892595299117528 0.0584117093989473 1.0 0.5628202716423423 18 Q86YN1,Q9BT22,Q96AA3,P46977,Q2TAA5 5 +Cellular pigmentation 0.6656244696368389 1.8906620674345769 0.058669469120677 1.0 0.5628202716423423 9 Q13561,Q9NP58,O00203 3 +Cerebellar purkinje cell layer development 0.7222257358082365 1.889200229962542 0.0588650039402567 1.0 0.5628202716423423 7 O14949,P04062,P54802 3 +Phospholipid transport 0.5795147299642256 1.8873893348454711 0.0591079785490045 1.0 0.5628202716423423 15 Q9NZD2,P08183,P61916,Q4KMQ2,Q7Z3C6,Q14108,Q8WTV0 7 +Bone development 0.5162829324380961 1.8867481396150163 0.0591942094388153 1.0 0.5628202716423423 26 P16435,O75844,P04637,Q9NX62,O96028,Q92896,Q7Z3C6,Q15125 8 +Cellular response to oxygen levels 0.4988921418482977 1.884156639429114 0.0595437907606417 1.0 0.5653188181108743 36 P02545,Q8N511,O95831,P09601,Q9UNE7,Q96HE7,Q99623,P61421,P04637,Q15904,Q9Y4P3,P55786,Q96A26,Q9Y487,O75306,Q04656 16 +Response to activity 0.5932425185787135 1.8805316833009185 0.0600356525364471 1.0 0.5661145269222663 14 P40939,Q16836,O43819,Q6KCM7 4 +Cellular response to increased oxygen levels 0.7480078311455802 1.8784255965255343 0.0603229666335103 1.0 0.5661145269222663 6 Q8N511,Q9Y487 2 +Antigen processing and presentation of peptide antigen 0.577983114379586 1.8777035456264448 0.0604217314141011 1.0 0.566225520431713 15 Q03519,Q6P179,Q9UIQ6,Q9NZ08,P04439,Q03518,Q99538,P10321,P14735,P50570 10 +Locomotory behavior 0.5107866436136173 1.8763507846091216 0.060607127831874 1.0 0.5666302824008572 29 O75844,P50897,P54802,P05067,O15118,P51790,Q04656,Q96RL7 8 +Sensory perception 0.5035724784756479 1.8729527007775288 0.0610749167907558 1.0 0.5666302824008572 33 O60313,P50897,Q08257,Q9Y5J9,Q99797,Q6P4Q7,Q9Y6M9,Q92696,Q9BPW8,Q14108,Q9H6K4,O76024 12 +Regulation of endoplasmic reticulum tubular network organization 0.7812536266827467 1.864130099687268 0.0623034365295731 1.0 0.5666302824008572 5 Q15041 1 +Lysosomal transport 0.4702966611796542 1.8625375743674513 0.0625273542581401 1.0 0.5666302824008572 46 Q96L92,P11279,P07602,Q96ED9,Q9NZJ7,P13473,Q14108,O15118 8 +Homologous chromosome segregation 0.6590557411982191 1.8557532749221803 0.0634887333615603 1.0 0.5695621492890394 9 Q9BTX1,Q15645,Q92791,P46379 4 +Calcium ion import 0.5729790681038214 1.84598748098534 0.0648940232024111 1.0 0.5765762466506082 15 O75844,Q96AQ8,Q8NE86,P23634,Q9Y4W6,Q8WWC4,P21796,Q9BPX6,P16615 9 +Positive regulation of release of cytochrome c from mitochondria 0.7770520780609338 1.8456301501477328 0.0649459256338174 1.0 0.5765762466506082 5 O14737,Q96A26 2 +Regulation of protein lipidation 0.8818755941407483 1.8448000822797832 0.0650666254698828 1.0 0.5765762466506082 4 P04062 1 +Regulation of lipoprotein metabolic process 0.8818755941407483 1.8448000822797832 0.0650666254698828 1.0 0.5765762466506082 4 P04062 1 +Behavior 0.4059370492015663 1.8433460899471643 0.0652784958069885 1.0 0.5765762466506082 75 Q92542,P30536,P54802,Q9GZP9,Q96RL7,P50897,P17900,P05067,Q04656,O15118,O75844,O76024,P04062,P51790,Q13641,P04637,P10253,P04035,O00264 19 +Erad pathway 0.4820135393369447 1.8418716811612552 0.065493921809995 1.0 0.5772150375487113 41 P46379,Q9UBV2,Q9GZP9,O75477,Q9BUN8,O14656,Q7L5D6,Q96CS3,O76024,Q8IXB1,Q4ZIN3,O43765,P27824,Q8TCT9,O60858,P51572,O94905,Q96A33,Q04323,Q6NTF9 20 +Positive regulation of mitochondrial translation 0.6831804361979454 1.8347844376245024 0.0665376353693303 1.0 0.5835691377400022 8 Q9Y2R0 1 +Cdp diacylglycerol metabolic process 0.6829436183534257 1.83357851632319 0.0667165836921044 1.0 0.5835691377400022 8 O95674,Q96BW9,Q9HCL2,Q9NUQ2,Q6UWP7,O14735 6 +Negative regulation of lipid biosynthetic process 0.682896158779286 1.8333368253518336 0.0667524961793799 1.0 0.5835691377400022 8 P38398,P05023,O94905,Q8NF37 4 +Regulation of membrane lipid distribution 0.773481522744691 1.8298829167692416 0.0672674484660829 1.0 0.5836928188987087 5 Q96CP7,Q96AA3,Q7Z3C6 3 +Positive regulation of protein kinase b signaling 0.5496753852623175 1.8261755566326805 0.0678238219999252 1.0 0.5836928188987087 18 Q86UE4,O00165,Q13641,Q9NQC3 4 +Cardiac cell development 0.6260013899372456 1.823811175711177 0.0681806237468511 1.0 0.5836928188987087 11 O75844 1 +Regulation of tor signaling 0.598180108241525 1.823803540261393 0.0681817784852867 1.0 0.5836928188987087 13 O75844,P04062,Q15382 3 +Skeletal system development 0.4563950327443671 1.821764533948475 0.068490721268879 1.0 0.5836928188987087 49 P16435,O75844,Q96HY6,Q15125,P04637,Q9NX62,Q15904,Q15043,O96028,Q92896,P51812,O43252,Q7Z3C6,O95470,Q92543,Q04656 16 +Embryonic heart tube development 0.7082841434771876 1.8214697674848384 0.0685354782541503 1.0 0.5836928188987087 7 Q15363 1 +Lysosomal lumen acidification 0.875971401927248 1.8209334091832996 0.068616979921084 1.0 0.5836928188987087 4 P50897,Q8N511,O75503 3 +Reactive nitrogen species metabolic process 0.555301879457463 1.817380488174538 0.0691588732779528 1.0 0.5840064578242403 17 P16435,P30536,P06280,Q08722,O43169 5 +Regulation of glycoprotein metabolic process 0.6247028365889264 1.8164797523752896 0.0692968111219942 1.0 0.5840064578242403 11 P62820,P35610,Q92542,Q9H0U4,Q9NQX7 5 +Early endosome to golgi transport 0.8748433189739449 1.8163681911886265 0.0693139112136864 1.0 0.5840064578242403 4 O60749,O60499 2 +Leukocyte degranulation 0.624056344693034 1.8128276702400188 0.0698584048067827 1.0 0.5855698719518352 11 Q9UNH7,Q99584,P11279,P09601 4 +Prostate gland development 0.7334617555312605 1.8106695729434965 0.0701920155212223 1.0 0.5860096480040958 6 P07602 1 +Negative regulation of amyloid precursor protein catabolic process 0.6372498028371536 1.8103801574760656 0.0702368542286224 1.0 0.5860096480040958 10 P49755,Q9NQC3,O95197,O75298 4 +Long chain fatty acyl coa biosynthetic process 0.7049147548224844 1.805031636946252 0.0710697315101338 1.0 0.5860096480040958 7 Q9NZ01,Q9UKU0 2 +Cellular response to unfolded protein 0.4999720644538064 1.8038138064308329 0.0712605007245883 1.0 0.5860096480040958 30 P48723,Q96HY6,Q15363,Q9NRK6,Q96HE7,Q9BUN8,P57088,Q9Y4P3,Q6NTF9,Q92905,Q9GZP9,O76024 12 +Regulation of bone mineralization 0.7667564265818275 1.800159933480599 0.0718353883133875 1.0 0.588227939152878 5 O75844,P20020 2 +Regulation of defense response to virus 0.5451990000866089 1.7960198174466504 0.0724913653190975 1.0 0.5891415424352012 18 O75844,Q969V5,O43657 3 +Cellular response to topologically incorrect protein 0.4878913600586955 1.7935245706095182 0.0728890854405084 1.0 0.5893518199912104 36 P48723,Q96HY6,Q15363,P46379,Q96HE7,Q9NRK6,P57088,Q9BUN8,O14656,Q9Y4P3,Q6NTF9,Q92905,Q9GZP9,O76024 14 +Cellular response to exogenous dsrna 0.6743267610790218 1.7895995020524014 0.0735183186168706 1.0 0.5893518199912104 8 Q5KU26,Q969V5,O75955 3 +Natural killer cell mediated immunity 0.6725162741240591 1.780334407807108 0.0750212492887794 1.0 0.5908263562488758 8 P11279,P01889,P04439,P51809,P33176 5 +Pigment metabolic process 0.4983625701783812 1.779608852099922 0.0751399965105608 1.0 0.5910468566102446 29 P22830,P09601,P30519,Q7KZN9,Q9NP58,O00264,Q9P0S9,Q04656 8 +Amide transport 0.4745151331173248 1.7769829010282192 0.0755710531858999 1.0 0.5915710012442649 41 Q03519,O00400,Q8NE86,Q9Y289,P07602,Q9NZD2,P62820,P53985,Q03518,Q9H2D1,Q9NZJ7,P50416,Q9BRT2,P40939,Q92543,Q16836,Q8N5M9 17 +Negative regulation of leukocyte mediated immunity 0.7261108487503045 1.776258970476984 0.07569024250954 1.0 0.5915710012442649 6 P04439,P09601 2 +Multicellular organism growth 0.5001967650396011 1.7732964022456643 0.0761796049159544 1.0 0.5930364709471547 27 O75844,Q15363,Q9HCL2,P05067,O95470,Q6KCM7 6 +Neuron apoptotic process 0.4574148738360544 1.772548935988307 0.0763034796029042 1.0 0.5930364709471547 47 O14578,P50897,O95831,P09601,Q01105,P07196,P04637,Q92542,Q15233,Q9UNH7,P05067,P04062,Q07820,Q96A26,P31751,Q15375,Q99720,O76024 18 +Antigen processing and presentation of exogenous antigen 0.642817436097055 1.768907566402894 0.0769093012960064 1.0 0.5934955916361259 9 Q9UIQ6,P04439,Q99538,Q03518,P50570,O00203 6 +Excretion 0.7235098316374404 1.7640564196278172 0.0777224807495304 1.0 0.5948701058351529 6 Q96PU5,Q9Y5X3,P09601 3 +Homologous chromosome pairing at meiosis 0.669310325079414 1.763907267724302 0.0777475930541575 1.0 0.5948701058351529 8 Q9BTX1,Q15645,Q92791,P46379 4 +Metal ion transport 0.425725474653722 1.762946918883619 0.0779094426957447 1.0 0.5948701058351529 100 Q8NE86,Q9Y289,Q96HE7,P30536,P20020,P55011,Q4KMQ2,P05023,Q9UM00,O15173,P16615,Q12959,Q96PU5,P98194,O75323,P23634,P21796,P27105,P35670,Q6KCM7,O95202,O75844,O76024,Q04656,Q15043,Q6P4Q7,Q9BPX6,P54709,Q9H9B4,Q9HD20,Q9NP58,Q9NUT2,P11413,Q96AQ8 34 +Pinocytosis 0.6688858659922021 1.7617303707024483 0.0781148639553508 1.0 0.5951565124576675 8 P50897,Q9BZG1,Q9H223,Q9Y5X3,Q9UKG1 5 +Negative regulation of type i interferon mediated signaling pathway 0.6958267804108382 1.760562548458068 0.0783124721597146 1.0 0.5951565124576675 7 Q14166 1 +Regulation of nik nf kappab signaling 0.5580168246696426 1.7505128766408578 0.0800298541922532 1.0 0.6011931261293489 15 Q99623,P05067,O43657,P35232,Q12959 5 +Cellular response to nutrient 0.7552084253000986 1.7489317016515855 0.0803028259480673 1.0 0.6013707653265037 5 Q8TB36,P09601 2 +Positive regulation of autophagy 0.4944072947992908 1.7486025245054688 0.0803597496320169 1.0 0.6013707653265037 29 P12235,P09601,Q9Y371,Q86UE4,P21796,O15269,Q6UWE0,O60858 8 +Intestinal absorption 0.6389737347899004 1.7482379260448486 0.0804228368799915 1.0 0.6013707653265037 9 Q16739 1 +C4 dicarboxylate transport 0.6930953317005614 1.747159897444561 0.0806096058289371 1.0 0.6019689976881021 7 O75746,Q9UBX3,P55011,Q9UJS0 4 +Aminoglycan biosynthetic process 0.6255133572221596 1.74566327776795 0.0808694797039235 1.0 0.6019689976881021 10 Q8N6G5,Q8NCH0,Q96L58,Q7LGA3,P06865,O94923 6 +Purine nucleotide transport 0.5985805746947404 1.7456275537148431 0.0808756911510915 1.0 0.6019689976881021 12 P12236,O00400,Q6NUK1,P05141,Q8TB61,P12235,Q08722,Q8TDW0,Q6KCM7 9 +Necrotic cell death 0.544402921427373 1.7451143347063431 0.080964968827695 1.0 0.6019689976881021 17 P04637,P00403,Q13510,Q7Z3C6,P12235 5 +Negative regulation of macroautophagy 0.5981376250784279 1.7430333126732964 0.0813277960243334 1.0 0.6032593896167074 12 Q9NRR5,P04637,P09601,O15118 4 +Peroxisomal transport 0.7537682143068333 1.7425262716541736 0.0814163985065385 1.0 0.6032593896167074 5 P40855,O75381,P56589 3 +Regulation of cell aging 0.6244462555997863 1.7397580678315578 0.0819015082874665 1.0 0.6040102804805184 10 O75844,P02545,Q9NX47 3 +Lipid storage 0.5500020427593536 1.7392248120753953 0.0819952266918659 1.0 0.6040102804805184 16 P17900,Q14534,Q9H6V9,P04062,Q8WTV0 5 +Lipid droplet organization 0.6644621054197954 1.7390150084682363 0.082032123000501 1.0 0.6040102804805184 8 O95674,Q14534 2 +Mucopolysaccharide metabolic process 0.6108016549155166 1.737646829375784 0.0822730629230432 1.0 0.6040102804805184 11 P16278,Q8N6G5,Q8NCH0,Q9NX62,Q96L58,O94923,O43505 7 +Response to testosterone 0.6639131872262981 1.7361929095585742 0.082529730563138 1.0 0.6040102804805184 8 Q13126,P04062 2 +Energy derivation by oxidation of organic compounds 0.4494627746299561 1.7345316656108292 0.0828237922930232 1.0 0.6040102804805184 127 O14949,Q9BSK2,P06576,P20674,P56385,Q7KZN9,Q9UDW1,P09622,O43819,P03886,P22695,O43676,O95139,P14406,O14548,P24539,P08574,O75323,P00403,Q99643,Q13423,Q6KCM7,Q04656,Q16134,Q9H3K2,P35573,P13073,O95168,Q15070,O95299,P04062,P46020,O96000,O75964,Q9Y6M9,O75208,Q9BRT2,P21912,Q9UJS0,O75746,P04637,P10253,P31751,P51970 44 +Mitochondrial fission 0.555497699321091 1.7343445529432535 0.0828569668029803 1.0 0.6040102804805184 15 O60313,Q8NE86,Q9NX47,Q8TB36,Q9NUQ9,Q969V5,O00203 7 +Potassium ion homeostasis 0.751158077019563 1.730908343045365 0.0834681133616215 1.0 0.6047028056999343 5 P05023,P55011,P54709 3 +Mitophagy 0.5825314478847232 1.7297393473278295 0.0836768553020774 1.0 0.6055415095360339 13 Q99623,O95140,P04637,P21796,P12235 5 +Regulation of toll like receptor signaling pathway 0.6087003494141512 1.7256754631625095 0.0844058147186266 1.0 0.6087874543326858 11 Q9NQC3,Q9UBC1,Q9NPR9,O75955,Q14254 5 +Negative regulation of release of cytochrome c from mitochondria 0.7497937059904385 1.7248307390870894 0.0845579803504645 1.0 0.6092103163966547 5 Q9H3K2,P02545 2 +Embryonic digit morphogenesis 0.6883827619075573 1.7239964393136191 0.0847084859620344 1.0 0.6096202973157238 7 Q9NX62 1 +Phospholipid metabolic process 0.4031240530896634 1.7214130441446855 0.085175898922561 1.0 0.6102867213230365 82 Q9NX62,P35790,Q96N66,O15269,Q10713,P40939,O14735,Q92604,Q8WTV0,O95674,Q92643,P53602,Q8NHP8,Q9NUQ2,P48651,Q9BVG9,Q01968,Q99623,Q6IAN0,Q96PE3,Q9NTJ5,Q8N2K0,Q9UG56,Q8IY17,Q9UJZ1,Q9Y263,Q86YN1,Q9BTU6,P37268,Q9H490,Q9HCL2,Q9NPH0,Q96S52,Q6UWP7,O15228,Q5H8A4,P14324,Q8NF37 38 +Protein exit from endoplasmic reticulum 0.5196505089834449 1.717651962126292 0.0858601163557342 1.0 0.6121386149431003 20 Q9BVK6,Q9BUN8,P51572,Q9NR31,Q8TCT9,Q9UBV2,Q9GZP9,Q96CS3 8 +Regulation of nadp metabolic process 0.7479269642286436 1.7165101476864484 0.0860687122726546 1.0 0.6121386149431003 5 P48163 1 +Mammary gland epithelium development 0.632883635716708 1.7154013654284253 0.0862716652462374 1.0 0.6121386149431003 9 Q9NQC3 1 +Regulation of organic acid transport 0.6063508689796382 1.7122733420977096 0.0868463069713711 1.0 0.612806726819212 11 P33121,Q7L0J3,Q9Y3D6,P55011,P31751,Q15041,O75915 7 +Negative regulation of transmembrane transport 0.5320679307678022 1.707006201384755 0.0878208997595564 1.0 0.6176668293669798 18 Q96PU5,Q9P2B4,P21796,O75915,Q04656 5 +Positive regulation of toll like receptor signaling pathway 0.7450272889206615 1.7035737131004485 0.0884607559120498 1.0 0.618097954762433 5 Q9NQC3 1 +Regulation of peptidase activity 0.3970931190708132 1.702249283843317 0.08870864759704 1.0 0.618097954762433 78 Q9P0J0,Q15392,P61289,Q92542,Q9UL46,P05067,Q96A26,O14737,O43847,P16435,O95831,P51812,Q969V5,Q15375,Q15041,Q96HY6,P49755,P51572,Q9NZJ7,Q04323,O75915 21 +T cell differentiation in thymus 0.6042689146801619 1.700382455832005 0.0890590096640397 1.0 0.618097954762433 11 Q5HYI8,P04062,O96005 3 +Negative regulation of ion transmembrane transport 0.5640812106557717 1.7000944814673815 0.0891131551546022 1.0 0.618097954762433 14 Q96PU5,P21796,Q04656 3 +Leukocyte mediated cytotoxicity 0.5772460914204214 1.6977643190069076 0.0895522527890491 1.0 0.6199935670400676 13 P11279,P53634,P04439,O15400,P33176,P51809,Q9NUQ9 7 +Glutamate receptor signaling pathway 0.7436970085224727 1.6976341241705517 0.08957683810605 1.0 0.6199935670400676 5 P05067,Q8NCG7,Q92542 3 +Regulation of alcohol biosynthetic process 0.7432089376733251 1.695454183317103 0.0899892947152527 1.0 0.6214745971323368 5 P16435,Q9UBM7,O94905 3 +Regulation of cholesterol biosynthetic process 0.7432089376733251 1.695454183317103 0.0899892947152527 1.0 0.6214745971323368 5 P16435,Q9UBM7,O94905 3 +Antigen processing and presentation of exogenous peptide antigen 0.7087299591906105 1.694456736947583 0.0901785260200147 1.0 0.6215161269506414 6 P04439,Q99538,Q03518,Q9UIQ6 4 +Pyramidal neuron differentiation 0.8446972626039093 1.6937873515475417 0.090305698453545 1.0 0.6217346871331281 4 O14949,P04062 2 +Ion transport 0.5093020018834542 1.6929677268540697 0.0904616104151241 1.0 0.6221504420630448 209 P20674,Q9C0H2,P05141,Q9H2D1,P20020,Q9UDW1,P55011,Q4KMQ2,Q9UM00,O15173,Q8TDW0,Q12959,P07602,P24539,P08574,P23634,P45880,P21796,Q6P4A7,Q13423,Q9UHG3,P35670,O95202,O75844,Q70HW3,P13073,Q9Y277,P30825,O75964,Q9UNH7,P54709,Q9H9B4,Q9UBX3,Q9HD20,Q9NZJ7,O43808,P11413,O00400,Q8NE86,Q9Y289,Q96HE7,Q7KZN9,P16615,Q96PU5,O14548,Q8TB61,P27105,P51798,Q6KCM7,O76024,Q99623,Q9BQT8,Q15043,Q15041,P51790,O60831,Q9UJS0,Q96S66,Q08722,Q9Y619,O43681,Q9NW15,P05023,P98194,Q6NUK1,P00403,P05067,Q96ES6,Q04656,P0CG08,Q6P4Q7,P12236,Q9NUT2,Q9NP58,Q7L0J3,P12235,Q96AQ8,P06576,Q9HC21,P56385,Q14728,P30536,P53007,O75323,O14656,O96008,Q8NE01,Q9BPX6,O75746,P04920,O75915 91 +Response to oxygen levels 0.4025892537078827 1.6867419817888198 0.091652975826882 1.0 0.6232187762622076 60 P02545,Q8N511,P09601,P52789,Q99623,P30519,P04637,Q9Y4P3,Q96A26,Q9Y487,Q04656 11 +Cellular hormone metabolic process 0.5290881035459395 1.68669256977274 0.0916624815561573 1.0 0.6232187762622076 18 Q9HB40,P42892,Q8NBN7,P30536,Q53GQ0,O95470 6 +Gpi anchor metabolic process 0.6780942047127854 1.6732531329587388 0.0942774745054788 1.0 0.6330197850043132 7 Q96S52,Q5H8A4,Q92643 3 +Lipoprotein catabolic process 0.7377407407679992 1.6710036653352056 0.0947209538335804 1.0 0.635342504962008 5 P50897 1 +Multicellular organism aging 0.6243923036265695 1.6694427705413708 0.0950296632861973 1.0 0.6364866159473762 9 O75844,Q9UGP8,P04637,P04062 4 +Mitochondrial electron transport nadh to ubiquinone 0.4896654592649537 1.6684674004029434 0.0952229781363376 1.0 0.6367425632463727 24 O95168,O95299,O96000,P09622,Q9Y6M9,O75208,P03886,O43676,O95139 9 +Er associated misfolded protein catabolic process 0.6769100743482559 1.6673980540887814 0.095435280554802 1.0 0.63722710106512 7 P46379,Q9BUN8 2 +Reticulophagy 0.7368660304109261 1.667087902377694 0.0954969273132695 1.0 0.63722710106512 5 Q9Y6I9 1 +Negative regulation of autophagy 0.4882584664684651 1.6646000546714594 0.0959925744548215 1.0 0.6374665062523414 25 P09601,P04637,P30536,Q07820,P10619,O15118 6 +Zinc ion homeostasis 0.8367351796595905 1.6612344767196012 0.0966663638186273 1.0 0.6374665062523414 4 P35670,Q15043 2 +Sarcoplasmic reticulum calcium ion transport 0.7354465121614917 1.6607305710847595 0.0967675706452875 1.0 0.6374665062523414 5 O75844 1 +Cell maturation 0.4855252975126 1.6594388490070169 0.0970273934032119 1.0 0.6383226396314339 27 Q8N2A8,Q9NZJ7,P04062,P05067,O75503,Q12768,Q15645 7 +Natural killer cell activation 0.648878522367394 1.658602797605274 0.0971958576848381 1.0 0.6387856923323422 8 Q5HYI8,P11279,Q96L92 3 +Mitochondrion localization 0.5373228459509111 1.6559876059976386 0.0977243287730604 1.0 0.6403204761558781 16 Q8IXI1,O60313,Q8IWA4,P07196,O95140,O75153,Q969V5 7 +Regulation of insulin secretion 0.5108015216628635 1.6548197685502797 0.0979610627485136 1.0 0.6405287749701487 20 Q8NE86,P53985,P50416,Q9BRT2,P40939,Q16836,Q8N5M9 7 +Regulation of amyloid precursor protein catabolic process 0.5566978090481051 1.6538779708642355 0.0981523094262133 1.0 0.6405287749701487 14 O95197,Q16799,P49755,Q9NQC3,O75298,Q96P70 6 +Signal peptide processing 0.7337820795922655 1.6532722189992215 0.0982754742901526 1.0 0.6405287749701487 5 P67812,O75503,Q15005 3 +Neuron death 0.3839414332411829 1.652851616478233 0.0983610661398868 1.0 0.6405287749701487 70 P07196,Q15392,Q92542,Q07820,P50897,P09601,P05067,Q96A26,O76024,O14578,O95831,Q01105,Q4ZIN3,P04062,Q15375,Q9UNH7,Q99720,P04637,Q15233,P31751,O75915 21 +Muscle adaptation 0.542102915725313 1.6479292219665365 0.0993671960727025 1.0 0.6414051987028997 15 P02545,P09601 2 +Chaperone mediated autophagy 0.6466827290574764 1.6472242316153565 0.0995119649127826 1.0 0.6414051987028997 8 P13473 1 +Membrane fusion 0.4660557610775575 1.6447849640803465 0.1000141639781835 1.0 0.641711297235208 38 Q86Y82,O15498,Q8IWA4,O60499,Q9Y3E7,O15400,Q12981,Q9UQN3,O75396,Q9UNK0,Q9P2W9,Q9BZG1,P31751,O95249,P51809,Q99747 16 +Regulation of atp metabolic process 0.4794794042537442 1.6412357486041482 0.1007484876412434 1.0 0.641950882041558 30 Q9BSK2,P14406,O14548,O75746,P04637,P30536,P00403,P05067,Q9BRT2,Q04656 10 +Regulation of lipid metabolic process 0.4098297102017196 1.6384099530399727 0.101336204287628 1.0 0.6426511183304005 57 P30536,Q96N66,Q96G23,P05023,Q92604,Q8WTV0,P07602,Q13510,P50416,Q9UBM7,P16435,O75844,Q99623,P61916,Q8NCG7,Q9H6K4,O94905,Q9NZJ7,Q8NF37 19 +Vacuolar localization 0.5402867324967388 1.6361554824636428 0.1018070507699668 1.0 0.644382236797662 15 Q99584,P09601,Q9BZG1,Q86YV9,Q9UNH7,Q9H267,P51809,P33176 8 +Collagen biosynthetic process 0.8303816138749193 1.6352089261094984 0.1020052575999936 1.0 0.6449117395435608 4 Q92791 1 +Long chain fatty acyl coa metabolic process 0.617111300616537 1.6298758824617074 0.1031277318335581 1.0 0.6467893006181253 9 Q9NZ01,Q9UKU0 2 +Iron ion transport 0.6170934954144865 1.6297789472423905 0.1031482248232253 1.0 0.6467893006181253 9 O15173,Q04656,Q15043 3 +Dermatan sulfate proteoglycan metabolic process 0.9670705187946544 1.6282621285115606 0.1034693160665352 1.0 0.6467893006181253 2 Q8N6G5 1 +Plasma membrane organization 0.4814116514415389 1.627278096268418 0.1036780477484249 1.0 0.6467893006181253 27 Q96CP7,Q16739,Q9Y371,Q7Z3C6,P16615 5 +Amyloid precursor protein biosynthetic process 0.8277436254026205 1.6243908220054517 0.1042924246268495 1.0 0.6467893006181253 4 Q92542 1 +Positive regulation of biomineralization 0.8275721248287998 1.6236872712256156 0.1044425690008188 1.0 0.6467893006181253 4 P20020,P04920 2 +Glycosphingolipid biosynthetic process 0.8275391958793465 1.623552182625257 0.1044714178182508 1.0 0.6467893006181253 4 Q16739 1 +Negative regulation of leukocyte migration 0.6663717071193203 1.615157454247531 0.1062766014681415 1.0 0.6479839528325856 7 P09601 1 +Endomembrane system organization 0.4713287385679345 1.6150854226341302 0.1062921973222228 1.0 0.6479839528325856 165 Q9Y6Y8,Q15363,P46379,O43681,Q9UH99,P57088,Q9NQC3,Q15006,Q9P2W9,Q9H6H4,P16615,O95197,P50402,Q96ED9,O14656,Q9NPA0,Q12768,Q12981,O75844,P02545,Q8NHH9,Q16739,O43760,Q5JRA6,P20700,Q9Y371,Q7Z3C6,Q15041,Q14108,Q92543,P51790,Q8N5M9,Q96CP7,Q9BVK6,Q00765,P49755,Q96A33,O75955 38 +Response to ph 0.691856833251031 1.614477223516522 0.1064239533101922 1.0 0.6479839528325856 6 P04062 1 +Response to mitochondrial depolarisation 0.6399784387572203 1.6124111095425735 0.1068725089394817 1.0 0.6493103085101163 8 P04062,Q969V5,P52789 3 +Regulation of autophagy of mitochondrion in response to mitochondrial depolarization 0.6399784387572203 1.6124111095425735 0.1068725089394817 1.0 0.6493103085101163 8 P04062,Q969V5,P52789 3 +Response to increased oxygen levels 0.6394428822972626 1.609625547823116 0.1074796274198637 1.0 0.6494355805656467 8 Q8N511,Q9Y487 2 +Vesicle cargo loading 0.5623645479473564 1.607194688616463 0.1080116668166537 1.0 0.6496951220725528 13 Q5JRA6,Q15363,P49755,Q96PC5,Q9NR31 5 +Mitochondrial dna metabolic process 0.6901956863699049 1.6065744107624236 0.1081477596463285 1.0 0.6496951220725528 6 P49916,P04637,P39210 3 +Ether biosynthetic process 0.7223258706467626 1.601817318057885 0.1091960123125526 1.0 0.6518731697448719 5 O00116,P49327,Q6IAN0,O15228 4 +Neuron recognition 0.6630633111131116 1.5987090180130472 0.1098852729054793 1.0 0.6544166943967968 7 Q9NQC3,P35613 2 +Glial cell proliferation 0.6883176940724545 1.597633916308584 0.1101244736770903 1.0 0.6544166943967968 6 P04062,Q96G23 2 +Response to tumor necrosis factor 0.4722042624515634 1.5939057604108149 0.1109571440453394 1.0 0.6574082794374883 31 P04637,P04062,Q8TCT8,Q13510,Q99828,Q9Y5A7 6 +Pigment granule organization 0.7204945700110272 1.5935732692382656 0.111031645536809 1.0 0.6574082794374883 5 Q9NP58 1 +T cell proliferation 0.4787528343401802 1.5912314697527392 0.1115574930484106 1.0 0.6579074659420032 25 P10644,P04439,P04637,Q9HCL2,Q92542,P30825,Q12959 7 +Regulation of er to golgi vesicle mediated transport 0.6869143949654701 1.5909491183523512 0.1116210271558288 1.0 0.6579074659420032 6 Q9HCU5,Q9P2W9,Q9NR31 3 +Positive regulation of membrane potential 0.7196952861351246 1.5899735063817697 0.1118407770491662 1.0 0.6583809449360526 5 Q8IWA4,P31751 2 +Calcium ion transport 0.4086664510229117 1.5875802758552275 0.1123812812575792 1.0 0.6605950224103013 56 O75844,Q96AQ8,Q8NE86,P98194,Q96HE7,O75323,P23634,P30536,P11413,P20020,P21796,O95202,Q4KMQ2,Q9UM00,Q9BPX6,Q6KCM7,P16615,O76024 18 +Phosphatidylserine metabolic process 0.7185432206678863 1.5847832200826666 0.113015596149365 1.0 0.6619339727705168 5 P48651,Q9BVG9 2 +Determination of adult lifespan 0.6854235625812134 1.583843477671997 0.1132293425173336 1.0 0.6625855708230389 6 O75844,P04062 2 +Leukotriene biosynthetic process 0.8177633258352213 1.5834000456817094 0.1133303125897229 1.0 0.6625855708230389 4 Q99735,Q9UJ14 2 +Response to chemokine 0.6851042412181788 1.5823210054558527 0.1135763078439371 1.0 0.6632796267111286 6 Q99828 1 +Autophagosome organization 0.4775281785199158 1.5817405211815856 0.1137088181880563 1.0 0.6632796267111286 25 Q86Y82,P62820,O95140,Q9Y371,P04062,Q7Z3C6,Q6UWE0,P16615 8 +Regulation of regulated secretory pathway 0.493392500243563 1.5799359161461854 0.1141215430362667 1.0 0.6632796267111286 21 P09601,P16615 2 +Regulation of natural killer cell mediated immunity 0.7164032226640884 1.5751368489285982 0.1152248600684098 1.0 0.6658913164379353 5 P11279 1 +Neuron maturation 0.6834890561277454 1.5746172979860404 0.1153448076266059 1.0 0.665947188029347 6 O75503,Q9NZJ7 2 +Polyol biosynthetic process 0.5820468437166024 1.5726173864374458 0.1158074393651023 1.0 0.6668911163438649 11 P04062,Q13510 2 +Nucleotide transmembrane transport 0.5937528965384457 1.5684578559874844 0.1167743179887179 1.0 0.6709735901463214 10 Q9BSK2,P12236,P05141,Q8TB61,Q9H2D1,P12235,Q8TDW0 7 +Response to food 0.6818661514015615 1.5668721450568408 0.1171445797230219 1.0 0.6709735901463214 6 P80303,P53985,Q6KCM7,P11413 4 +Antiviral innate immune response 0.7141227302133242 1.5648497466706237 0.1176181441884089 1.0 0.6709735901463214 5 Q9NVI7,Q99623 2 +Regulation of peptide transport 0.4913188269122537 1.564734312983793 0.1176452193788024 1.0 0.6709735901463214 21 Q8NE86,P53985,P50416,Q9BRT2,P40939,Q16836,Q8N5M9 7 +Organelle membrane fusion 0.4723685532899041 1.5647117814844882 0.1176505047552138 1.0 0.6709735901463214 28 Q86Y82,Q8IWA4,O60499,Q9Y3E7,O15400,Q12981,O75396,Q9UNK0,Q9BZG1,P31751,O95249,P51809 12 +Tetrapyrrole catabolic process 0.9466384310764906 1.564276621547465 0.1177526199197367 1.0 0.6709735901463214 3 P09601 1 +Calcium ion import into sarcoplasmic reticulum 0.9512270891581216 1.5633783451812828 0.1179636304999667 1.0 0.6715883963691287 2 O75844 1 +Calcium ion export 0.8123840727079517 1.561267353318553 0.1184606830551731 1.0 0.6720683177163261 4 P20020,O95202 2 +Acidic amino acid transport 0.5799767165839602 1.5606387701068472 0.1186090056886661 1.0 0.6722244430781564 11 O60831,Q9UJS0,O75746,P55011,Q15041,O75915 6 +Copi coated vesicle budding 0.81140662173031 1.557242865521335 0.1194128346796676 1.0 0.6750567649513675 4 Q9BVK6,Q15363 2 +Very long chain fatty acid metabolic process 0.6036620614774638 1.556415503823139 0.1196093208588788 1.0 0.6750567649513675 9 P33121,P28288,Q9P035,Q9UKU0,Q9NZ01 5 +Mitochondrial respirasome assembly 0.9487418452935664 1.5531962707217488 0.1203762520063844 1.0 0.6765924896272882 2 P14406 1 +Regulation of lipase activity 0.5659987624285989 1.5530367719114715 0.1204143499248648 1.0 0.6765924896272882 12 P16435,P50897,Q9Y263,Q99623,P35232 5 +Ubiquinone metabolic process 0.7115000321859591 1.553009641934077 0.1204208311360242 1.0 0.6765924896272882 5 Q86YH6,O75208,P22570 3 +Negative regulation of atp dependent activity 0.6537508998394741 1.552290976560672 0.1205926160218266 1.0 0.6765924896272882 7 Q15070 1 +Macromolecule depalmitoylation 0.810082564323666 1.551789939587029 0.1207124939270549 1.0 0.6765924896272882 4 P50897 1 +Protein depalmitoylation 0.810082564323666 1.551789939587029 0.1207124939270549 1.0 0.6765924896272882 4 P50897 1 +Response to dexamethasone 0.6783169849086733 1.5499181387600784 0.1211611654218747 1.0 0.6785233623324763 6 P04062 1 +Glucosylceramide metabolic process 0.9424701849578664 1.5482412899195228 0.1215642137402972 1.0 0.6796117803352412 3 Q16739 1 +Regulation of programmed necrotic cell death 0.6522276518708918 1.5446819308189998 0.1224232175915951 1.0 0.6832411449649178 7 P04637,Q13510 2 +Epithelial cell differentiation involved in prostate gland development 0.9412854344794944 1.5436822267488213 0.1226653340550059 1.0 0.6840062677228197 3 P07602 1 +Adp transport 0.8075847062480533 1.541498748812422 0.123195447209653 1.0 0.6848770521075345 4 P12235,P05141,P12236 3 +T cell apoptotic process 0.5753043593184304 1.5335564559020525 0.1251388076913013 1.0 0.6886844081541991 11 P24390,Q9HCL2 2 +Maternal placenta development 0.8054278468884113 1.5326082009256008 0.1253724196432228 1.0 0.6886844081541991 4 Q15363 1 +Purine ribonucleoside metabolic process 0.6246617538162191 1.5324850799417091 0.125402776624798 1.0 0.6886844081541991 8 O60725 1 +Ribonucleoside metabolic process 0.6246617538162191 1.5324850799417091 0.125402776624798 1.0 0.6886844081541991 8 O60725 1 +Negative regulation of nitric oxide metabolic process 0.7064969416707144 1.5303961837638882 0.1259186930307363 1.0 0.6887463029820257 5 P30536,P06280 2 +Neural retina development 0.6492793877602735 1.5299417880032 0.1260311385278452 1.0 0.6887463029820257 7 Q8NBN7,P20020,P23634,P54802 4 +Neutral lipid biosynthetic process 0.6492614370988714 1.529851990830663 0.1260533691316712 1.0 0.6887463029820257 7 Q9HCL2,Q8WTV0 2 +Cellular response to starvation 0.4678591580833767 1.5288636018371573 0.1262982611582681 1.0 0.6895059303636215 28 P04062,P21964,Q9Y371,P13473 4 +Regulation of endoplasmic reticulum unfolded protein response 0.6482867152869384 1.524975079684433 0.1272653134833548 1.0 0.6903259594467508 7 P57088,Q96HY6,O76024 3 +Biomineralization 0.5488629171888353 1.524357416545861 0.1274194514841133 1.0 0.6903259594467508 13 O75844,P20020,Q6P4Q7,P04920 4 +Positive regulation of organic acid transport 0.6726109157488721 1.5226158822858211 0.1278548339127478 1.0 0.6909418827426372 6 P33121,Q15041,P55011 3 +Post embryonic development 0.5358974268425644 1.522578433390389 0.1278642088024808 1.0 0.6909418827426372 14 Q96A33,O95470 2 +Cellular potassium ion homeostasis 0.80166812233687 1.5171014747108582 0.1292410659919691 1.0 0.6934114320993501 4 P05023,P55011 2 +Positive regulation of oxidoreductase activity 0.5961304416231964 1.5150737525554614 0.1297537278054465 1.0 0.6944917104303667 9 P16435,P04899,P00374,Q9P0J1,Q04656,Q8WTV0 6 +Phosphatidylethanolamine metabolic process 0.8005354920141005 1.5124277901937369 0.1304250696382738 1.0 0.6944917104303667 4 P35790 1 +Triglyceride biosynthetic process 0.6704376620280823 1.512203122691946 0.1304821968844933 1.0 0.6944917104303667 6 Q9HCL2,Q8WTV0 2 +Regulation of autophagy of mitochondrion 0.5341309617982457 1.5113558208418452 0.1306978189345742 1.0 0.6944917104303667 14 O00165,P04637,P30536,P21796,P12235 5 +Protein targeting to membrane 0.4558465170104437 1.5100114683419472 0.1310404978733632 1.0 0.6944917104303667 35 Q9H9H4,P46379,O43681,Q9UGP8,P43307,Q99442,Q9Y3D6,P56589,P27105,P31751,P40855,Q15041,Q7L5D6,Q99828,O60725 15 +Antigen processing and presentation of exogenous peptide antigen via mhc class i 0.79896034563422 1.5059264361728653 0.1320860592627408 1.0 0.6960165889791515 4 Q03518,Q9UIQ6 2 +Mannosylation 0.6681381991247081 1.501177299941925 0.1333097096078321 1.0 0.7007636308925027 6 Q9BT22,Q2TAA5 2 +Kidney morphogenesis 0.6433594220383971 1.5002946020883234 0.1335381070893446 1.0 0.701219103257065 7 O75844 1 +Lens development in camera type eye 0.7974892199655887 1.4998526970802022 0.1336525633933405 1.0 0.701219103257065 4 P08670,Q99797 2 +Striated muscle adaptation 0.69914692342557 1.4971125159097032 0.1343639836218049 1.0 0.7040326832894733 5 P02545 1 +Proton transporting two sector atpase complex assembly 0.7967102819760777 1.4966360831191037 0.1344879758626604 1.0 0.7041159057825624 4 Q15070 1 +Pattern recognition receptor signaling pathway 0.4607156208674768 1.4900626435122135 0.1362077654137583 1.0 0.7104634437993749 30 Q99623,Q9NQC3,Q5KU26,P51812,Q86UT6,Q9NPR9,O75955,Q9NUD5,O43657,P35232,O00203 11 +Regulation of amyloid beta clearance 0.6646725841866672 1.4845439053701752 0.137664684377524 1.0 0.7104634437993749 6 Q16850 1 +Cellular response to glucose starvation 0.5666995033495762 1.4835171307004416 0.137937068474248 1.0 0.7104634437993749 11 Q9Y371,Q9Y4P3 2 +Ire1 mediated unfolded protein response 0.6640764260474717 1.4816807145742312 0.1384252709488473 1.0 0.7104634437993749 6 P57088,Q96HY6 2 +Response to salt stress 0.6640258998844006 1.4814380253360353 0.1384898881945617 1.0 0.7104634437993749 6 P04637,O95202 2 +Positive regulation of erad pathway 0.79284875002759 1.4806833286134289 0.1386909785402035 1.0 0.7104634437993749 4 P51572,Q4ZIN3 2 +Regulation of hormone secretion 0.4651890279185195 1.4798842238345118 0.1389041465695126 1.0 0.7104634437993749 24 Q8NE86,P53985,Q6ZWJ1,P50416,Q9BRT2,Q9UNH7,P40939,Q16836,Q8N5M9 9 +Phosphatidylethanolamine biosynthetic process 0.93041317179248 1.4780943779786822 0.13938251868352 1.0 0.7104634437993749 2 P35790 1 +Positive regulation of chemokine production 0.6389225864902534 1.4780326369695764 0.1393990428037379 1.0 0.7104634437993749 7 P09601 1 +Mast cell activation involved in immune response 0.6632885042415879 1.4778956884781125 0.1394357005401678 1.0 0.7104634437993749 6 Q9UNH7,Q99584,P09601 3 +Mast cell activation 0.6632885042415879 1.4778956884781125 0.1394357005401678 1.0 0.7104634437993749 6 Q9UNH7,Q99584,P09601 3 +Endoplasmic reticulum to cytosol transport 0.5287363629819682 1.4770162485643314 0.1396712817889138 1.0 0.7104634437993749 14 Q9BUN8,P51572,Q9UBV2,Q9GZP9,Q96CS3 5 +Phospholipid homeostasis 0.93010251630941 1.4768215740413158 0.1397234718964037 1.0 0.7104634437993749 2 Q9HCL2 1 +Intracellular lipid transport 0.5406621784614399 1.473748723441704 0.1405492589360299 1.0 0.7104634437993749 13 P61916,P23786,O15118 3 +Cd40 signaling pathway 0.7911601611733546 1.473704076090291 0.1405612849109059 1.0 0.7104634437993749 4 P35232,Q99623 2 +Steroid hormone biosynthetic process 0.6619422077230573 1.471426127017224 0.1411759119839593 1.0 0.7104634437993749 6 Q9UBM7,P30536,Q53GQ0 3 +Activated t cell proliferation 0.6929603778531325 1.4690427117073828 0.1418212047021656 1.0 0.7104634437993749 5 Q9HCL2 1 +Muscle hypertrophy in response to stress 0.7900243381474699 1.4690083955502382 0.1418305120753897 1.0 0.7104634437993749 4 P02545,P16615 2 +Protein processing 0.4363727319564595 1.4600963315086724 0.144263600708431 1.0 0.7161500239436062 42 P67812,O75844,Q9UG56,Q15392,P42892,Q92542,Q99797,Q92896,O75503,Q10713 10 +Alcohol metabolic process 0.3858244031328666 1.45590630710223 0.1454185218964485 1.0 0.7196890829115269 87 Q15392,Q9NX62,O15269,Q15800,Q10713,Q8WTV0,Q9Y394,P05067,Q13510,P51648,Q16850,Q9UBM7,O15118,P16435,Q14534,P61916,P04062,Q15125,Q14739,Q8NBN7,P37268,O94905,P04035 23 +Positive regulation of vacuole organization 0.6585936550074191 1.4553229129637832 0.1455798862263213 1.0 0.7199406218618306 6 Q9Y371 1 +Regulation of vacuole organization 0.5495218573764573 1.454351019090825 0.1458490123165639 1.0 0.7202677720582817 12 O75396,Q9Y371,Q9H0U4,Q6UWE0,Q14108 5 +Cartilage development involved in endochondral bone morphogenesis 0.7864643778475437 1.4542853222950485 0.145867218078439 1.0 0.7202677720582817 4 O75844 1 +Cellular response to cadmium ion 0.7862412552647419 1.453362269397113 0.1461231965680363 1.0 0.7204393484084939 4 P09601,Q04656 2 +Iron ion transmembrane transport 0.7857232780785883 1.451219287518325 0.1467188077925927 1.0 0.720829270486579 4 Q04656,Q15043 2 +Amino acid import across plasma membrane 0.6574895989697758 1.450009836672695 0.1470557761731674 1.0 0.720829270486579 6 P30825,Q15041 2 +Protein kinase b signaling 0.457738084560197 1.447973966508451 0.1476243315274337 1.0 0.720829270486579 28 Q13641,O00165,Q9NQC3,Q86UE4,Q969V5,Q99828,P35232,Q12959 8 +Organic cation transport 0.7840750299605048 1.4443990114802354 0.1486267686370093 1.0 0.722475564624452 4 Q70HW3,Q9HC21 2 +Glycoside metabolic process 0.6077727206496846 1.4437624826151934 0.1488057987159117 1.0 0.722475564624452 8 P04062,Q9NUJ1,P06280 3 +Regulation of t cell proliferation 0.4936877413433599 1.4422876019376725 0.1492212562804646 1.0 0.722475564624452 18 P10644,P04439,Q9HCL2,P30825,Q12959 5 +Protein deneddylation 0.6073974198644871 1.441784340230291 0.1493632219288556 1.0 0.722475564624452 8 Q9BT78,Q92905,Q7L5N1,O14656 4 +Regulation of vascular endothelial growth factor receptor signaling pathway 0.6868781094527321 1.4413999749280997 0.149471717362706 1.0 0.722475564624452 5 P18031,O75340,O14964,Q96TA1 4 +Ornithine transport 0.921404162783469 1.441189143676092 0.1495312545852543 1.0 0.722475564624452 2 P30825 1 +Macrophage differentiation 0.6856870520673974 1.4359817341963268 0.1510075389026155 1.0 0.7247694184765918 5 P04062 1 +Sperm motility 0.781784271059989 1.4349173314077288 0.1513106562985455 1.0 0.7248799244714317 4 P23634,Q9GZT3,Q96RL7 3 +Sodium ion transport 0.4583076302271628 1.4316690951774766 0.1522385450288021 1.0 0.7248799244714317 25 Q96PU5,P23634,Q6P4Q7,P55011,Q4KMQ2,P27105,P05023,P54709,Q12959 9 +Response to iron ion 0.629416572440682 1.4302196245200696 0.152653994735231 1.0 0.7248799244714317 7 P09601,Q04656 2 +Integrated stress response signaling 0.7801839348138666 1.4282915383995582 0.1532079623305307 1.0 0.7248799244714317 4 Q15363 1 +Perk mediated unfolded protein response 0.7801839348138666 1.4282915383995582 0.1532079623305307 1.0 0.7248799244714317 4 Q15363 1 +Regulation of morphogenesis of a branching structure 0.9111541206808084 1.427588922687933 0.1534102138602517 1.0 0.7248799244714317 3 Q9NQC3 1 +Cytosolic calcium ion transport 0.4657193111944456 1.4253082052047548 0.1540681293426564 1.0 0.7248799244714317 22 Q96AQ8,Q8NE86,Q96HE7,P23634,Q9Y4W6,Q8WWC4,P20020,P21796,Q9BPX6,P16615,O95202 11 +Amino acid import 0.5797500934070156 1.4246876321569697 0.1542475157988141 1.0 0.7248799244714317 9 P30825,Q15041,O75915 3 +Response to oxidative stress 0.3873754867151391 1.4246668304943593 0.1542535315965036 1.0 0.7248799244714317 91 Q9BXW9,Q96HE7,Q15392,Q9NX61,P00374,Q07820,O43169,P16615,Q6NUK1,P09601,P23246,P30519,O14656,Q9UJ14,P05067,P39210,Q04656,Q15165,O95831,Q16134,O95168,P04062,Q8TED1,Q99720,P04637,Q15233,O75306,P11413,O75915 29 +Retrograde vesicle mediated transport golgi to endoplasmic reticulum 0.4547538914760532 1.4240129973171982 0.1544427096793343 1.0 0.7248799244714317 28 Q9Y282,P24390,P49755,Q8TD16,O75396,O15258,Q9P2W9,Q12981 8 +Manganese ion transport 0.9101926662523284 1.4238814850915262 0.1544807823071314 1.0 0.7248799244714317 3 Q9HD20,Q15043 2 +Manganese ion transmembrane transport 0.9101926662523284 1.4238814850915262 0.1544807823071314 1.0 0.7248799244714317 3 Q9HD20,Q15043 2 +Negative regulation of epithelial cell apoptotic process 0.651199283608729 1.419705252349508 0.1556935083824027 1.0 0.7273964608066016 6 P09601 1 +Glycerol ether metabolic process 0.6267566964247107 1.4168139424439137 0.1565373322539445 1.0 0.7280206211852072 7 Q6IAN0,Q6PIU2,O00116,O15228,P49327 5 +Negative regulation of cell growth 0.4535352975842935 1.4142144091986624 0.1572989584856829 1.0 0.7280206211852072 28 Q9P0J0,P50897,P04637,Q9NQC3,Q969V5,Q15375,O14681,P35232 8 +Chondroitin sulfate proteoglycan metabolic process 0.7765844440742263 1.4133834809091084 0.1575430000227156 1.0 0.7280206211852072 4 Q8N6G5 1 +Lymphocyte migration 0.5662932999319776 1.4130020691181475 0.1576551157202002 1.0 0.7280206211852072 10 P04062,Q5JRA6,P05067 3 +Response to metal ion 0.3702114664571291 1.4127711282549664 0.1577230299819765 1.0 0.7280206211852072 62 Q13144,Q96PU5,Q6NUK1,P09601,Q9UJS0,Q14168,O75746,Q92542,P30536,P09960,Q9NP58,P05067,O15118,P35613,P35670,Q04656 16 +Protein targeting to vacuole 0.5007922261560614 1.4124549227314356 0.1578160545159659 1.0 0.7280206211852072 16 Q14108,P13473,Q96RL7 3 +Anterior posterior axis specification 0.5660070545823724 1.4113716645104888 0.1581350534532306 1.0 0.7280206211852072 10 Q5T9L3,Q15363,Q8N2A8 3 +Regulation of ire1 mediated unfolded protein response 0.6800009647830372 1.4100931288878529 0.1585121858928291 1.0 0.7280206211852072 5 P57088,Q96HY6 2 +Protein geranylgeranylation 0.9136377757067392 1.4093893247637457 0.1587200789063019 1.0 0.7280206211852072 2 P49354 1 +Retina morphogenesis in camera type eye 0.7755672987255056 1.4091694936103591 0.1587850559601493 1.0 0.7280206211852072 4 Q16706,Q8NBN7,P54802 3 +Positive regulation of smoothened signaling pathway 0.6488475252229597 1.4083610890208786 0.1590241750026995 1.0 0.7283575610355709 6 P16435,Q96J42 2 +Protein localization to extracellular region 0.3657956075132865 1.4072229662825095 0.1593612835465647 1.0 0.72852133089321 63 Q8NE86,Q96PC5,P55011,Q5T9L3,P40939,Q9UBV2,Q16836,P61026,Q96KC8,Q9HCU5,P50416,Q16850,Q5JRA6,P53985,P27824,Q9BRT2,Q92543,Q8N5M9,P49755,P04035,Q8TBQ9 21 +Adenylate cyclase inhibiting g protein coupled receptor signaling pathway 0.6247574576616107 1.4067303677952747 0.159507357262969 1.0 0.72852133089321 7 P07602 1 +Synaptonemal complex organization 0.6482211808142075 1.4053385335689903 0.1599206350734585 1.0 0.7289121418482124 6 Q15645,Q92791 2 +Tor signaling 0.4883703886825238 1.4051131633464684 0.1599876304285654 1.0 0.7289121418482124 18 O75844 1 +Fatty acid elongation 0.9123951537744612 1.4043031257262628 0.1602286039070337 1.0 0.7289121418482124 2 Q9P035 1 +Synaptic vesicle membrane organization 0.7743638079009394 1.4041827976331445 0.1602644230195977 1.0 0.7289121418482124 4 O43760 1 +Regulation of dendrite extension 0.6777102344730785 1.3996535746540582 0.161617082404113 1.0 0.729966752911226 5 Q96PU5,Q969V5 2 +Regulation of response to cytokine stimulus 0.4538629091736106 1.3966776804042516 0.162510518936666 1.0 0.730679028938208 25 Q8TCT8,Q14166 2 +Cellular response to dsrna 0.5620830585270424 1.3890021987837189 0.164832081434612 1.0 0.7358268381263229 10 Q5KU26,Q969V5,O75955 3 +Negative regulation of establishment of protein localization 0.4501953873810739 1.3873171370845214 0.1653450797616535 1.0 0.7358268381263229 28 P04035,Q16850,P40939,Q9GZP9,Q8N5M9 5 +Metencephalon development 0.4474628468192744 1.3820330120942967 0.1669615650615223 1.0 0.7361782971032078 30 O14949,P04637,Q92542,P54802,Q5KU26,P04062,Q04656 7 +Cell aging 0.4532140314821274 1.3820096398598958 0.1669687412323395 1.0 0.7361782971032078 23 O75844,P02545,P04637,Q9NX47 4 +Protein targeting to lysosome 0.5491437471266983 1.3808086842424203 0.1673377926332484 1.0 0.7361782971032078 11 Q14108,P13473 2 +Maintenance of protein location in cell 0.4598456508858564 1.3806461768733267 0.1673877778790851 1.0 0.7361782971032078 22 P52789,Q9UH99,P24390,O15258,Q96RL7 5 +Glycosylceramide catabolic process 0.9064926995961428 1.380151922237676 0.1675398733968354 1.0 0.7361782971032078 2 P04062 1 +Mitochondrial protein processing 0.6429856651347317 1.3800533375964612 0.1675702229712259 1.0 0.7361782971032078 6 Q99797,Q96TA2,Q9UJZ1,Q10713 4 +Positive regulation of t cell proliferation 0.5600880768998788 1.377616061843984 0.1683218592277442 1.0 0.7361782971032078 10 P30825,P04439,Q9HCL2 3 +Microglia differentiation 0.9055607331469347 1.376339951188619 0.1687164095428415 1.0 0.7361782971032078 2 P04062 1 +Regulation of reactive oxygen species metabolic process 0.4455965527412754 1.3762713016593917 0.1687376543890264 1.0 0.7361782971032078 31 Q9BSK2,P52789,P04637,P04899,P30536,P00403,P38398,P42785,P39210,P11413,P51790 11 +Regulation of monooxygenase activity 0.5709047244351432 1.375629042148288 0.1689365105332263 1.0 0.7361782971032078 9 P16435,P23634,P06280,Q8TCT9,Q04656,Q8WTV0 6 +Regulation of mitochondrial gene expression 0.5356760157009611 1.370819828644082 0.1704311281270838 1.0 0.7361782971032078 12 Q9Y2R0 1 +Neuromuscular process 0.4497764990383807 1.3701457076281671 0.1706414221790484 1.0 0.7361782971032078 26 O75844,P17900,P10253,P05067,P04062 5 +Glycosylceramide biosynthetic process 0.8960027248763331 1.3691592008803528 0.1709495161773637 1.0 0.7361782971032078 3 Q16739 1 +Gdp metabolic process 0.6703477632532933 1.3660644915217102 0.1719187221852274 1.0 0.738592768860413 5 Q14168,Q12959 2 +Positive regulation of amine transport 0.6702404057981878 1.3655743170393977 0.1720726122908056 1.0 0.7387665944957263 5 Q15041 1 +Negative regulation of amyloid beta clearance 0.8937373721559708 1.3604234672851168 0.1736959564340137 1.0 0.7411729657921746 3 Q16850 1 +Cellular response to copper ion 0.9015222118670394 1.3598263227276466 0.173884890485243 1.0 0.7411729657921746 2 P05067 1 +Cerebellar purkinje cell layer formation 0.901522211867034 1.3598263227276268 0.1738848904852492 1.0 0.7411729657921746 2 P04062 1 +Copper ion transmembrane transport 0.9015222118670334 1.3598263227276226 0.1738848904852505 1.0 0.7411729657921746 2 P35670 1 +Copper ion import 0.9015222118670334 1.3598263227276226 0.1738848904852505 1.0 0.7411729657921746 2 P35670 1 +Cellular response to iron ion 0.9015222118670329 1.35982632272762 0.1738848904852514 1.0 0.7411729657921746 2 P09601 1 +Oocyte maturation 0.6385655002431292 1.3586790781863478 0.1742483046149505 1.0 0.7412099067136942 6 Q12768 1 +Regulation of steroid hormone biosynthetic process 0.9009009009009 1.357286516553853 0.1746901898979764 1.0 0.7412099067136942 2 P05023 1 +Regulation of hormone biosynthetic process 0.9009009009009 1.357286516553853 0.1746901898979764 1.0 0.7412099067136942 2 P05023 1 +Substantia nigra development 0.509803833851257 1.355743731280584 0.1751807200606283 1.0 0.7428073110383284 14 P24539,Q16352 2 +Mononuclear cell differentiation 0.415491980867405 1.354049720254309 0.1757205156678409 1.0 0.7442961289599913 46 P0CG08,Q9BXW9,P24390,P04637,Q5HYI8,P55327,P04062,O96005,O00625,Q04656,O00203 11 +Endosome to lysosome transport 0.4560946426727206 1.352038339009629 0.1763630509093001 1.0 0.7442961289599913 22 Q9Y3E7,Q9UQN3,P20645,Q96ED9,Q9P253,Q9UNK0,P51809,Q9H267,Q96L92 9 +Negative regulation of neuron apoptotic process 0.4479875604962498 1.3502665625331274 0.1769304938867326 1.0 0.7442961289599913 25 P04062,P50897,P09601,O76024 4 +Myeloid leukocyte differentiation 0.4398261320133018 1.3495113786804205 0.1771727679997443 1.0 0.7442961289599913 33 O00165,Q15904,P04062,P05067,O00625,Q14739,Q8N5M9 7 +Regulation of dna templated transcription in response to stress 0.5550623941006015 1.3488939123183472 0.1773710438736928 1.0 0.7442961289599913 10 P04637,P09601 2 +Nik nf kappab signaling 0.4744896994892002 1.3486880961411898 0.1774371706325483 1.0 0.7442961289599913 19 Q9H000,Q99623,P05067,O43657,P35232,Q12959 6 +Icosanoid biosynthetic process 0.5430273926351474 1.3448455787631972 0.1786751077876918 1.0 0.7442961289599913 11 Q8NCG7,Q9H7Z7,Q99735,Q9UJ14 4 +O glycan processing 0.5886703596093231 1.342747589330976 0.1793537193681049 1.0 0.7442961289599913 8 Q8NBI6,Q8N4A0,Q10472 3 +Digestion 0.5307678664867936 1.3410878240237558 0.1798919400490475 1.0 0.7442961289599913 12 Q16739,Q8WTV0 2 +Lipid droplet formation 0.8885041099243713 1.3402449052811063 0.1801657368100453 1.0 0.7442961289599913 3 Q14534 1 +Negative regulation of fat cell differentiation 0.6646352886251418 1.3399679386870271 0.1802557686098151 1.0 0.7442961289599913 5 Q8N4Q0 1 +Peroxisome fission 0.6644746150529328 1.3392335150834265 0.1804946649154735 1.0 0.7442961289599913 5 P40855 1 +Sensory perception of mechanical stimulus 0.4897136838025131 1.337605626901842 0.1810250292109585 1.0 0.7442961289599913 16 Q9Y5J9,Q14108,Q9Y6M9 3 +Regulation of the force of heart contraction 0.6637778058904711 1.336048216713301 0.1815335139496383 1.0 0.7442961289599913 5 P10253,P05023,P16615 3 +Vitamin d metabolic process 0.8871911366958747 1.3351829306211866 0.1818164821106558 1.0 0.7442961289599913 3 P04062 1 +Embryonic axis specification 0.6105347405756337 1.3348217619093743 0.1819346892157849 1.0 0.7442961289599913 7 Q15363 1 +Protein localization to endoplasmic reticulum exit site 0.7573535473427625 1.3336331972645876 0.1823240977024334 1.0 0.7442961289599913 4 P51572 1 +Associative learning 0.5180858364782728 1.333369878286265 0.1824104522628695 1.0 0.7442961289599913 13 P05067,P04035,P50897,O00264 4 +Protein o linked glycosylation via serine 0.7571077897207951 1.332613178334057 0.1826587782306081 1.0 0.7442961289599913 4 Q10472 1 +Calcium ion transmembrane transport 0.4263562376784126 1.3324762401589394 0.1827037439538752 1.0 0.7442961289599913 40 Q96AQ8,Q8NE86,P98194,Q9UJZ1,Q96HE7,O75323,P23634,Q8WWC4,P11413,P20020,P21796,Q4KMQ2,Q9UM00,Q9BPX6,Q6KCM7,P16615,O95202 17 +I kappab kinase nf kappab signaling 0.3939040281668106 1.3311682978352517 0.1831336401866403 1.0 0.7442961289599913 53 P98194,Q96HY6,P09601,Q8TB61,Q9P035,O60858,Q86UE4,Q86UT6,Q969V5,Q9Y3E0,O43657 11 +Establishment of protein localization to vacuole 0.4777561184374046 1.3305791661332118 0.1833275214592202 1.0 0.7442961289599913 18 Q14108,P13473,Q96RL7 3 +Prostate gland growth 0.8857650389335793 1.3296851715624165 0.1836220225131781 1.0 0.744390884533651 3 P07602 1 +Negative regulation of defense response to virus 0.5857443294393433 1.327219277344507 0.184436157327112 1.0 0.7452126260755557 8 Q969V5,O43657 2 +Reactive oxygen species metabolic process 0.4216808228910305 1.3266588741502008 0.1846215509982758 1.0 0.7452126260755557 42 Q9P0J0,Q9BSK2,P52789,P04637,P04899,P30536,P00403,P38398,P42785,P39210,Q13423,P11413,P51790,Q04656 14 +Sulfur compound transport 0.5399136475418296 1.326504389671907 0.184672682095186 1.0 0.7452126260755557 11 O00400,Q9HC21,Q70HW3,Q8TB61,Q9UBX3,Q8TDW0 6 +Regulated exocytosis 0.4356582618603536 1.3259832128471956 0.1848452579235786 1.0 0.7454471609017138 34 P61026,Q4J6C6,Q99584,Q9BRK5,P09601,P11279,O43760,P49755,P04899,Q7L0J3,Q9UNH7,P16615 12 +Smad protein signal transduction 0.5498934644625664 1.3192977951315503 0.1870695746642643 1.0 0.7495051946879028 10 P08670,O00400,Q9UIQ6 3 +Protein targeting to peroxisome 0.753479695886339 1.3175529582495622 0.1876533419131443 1.0 0.7495051946879028 4 P40855,O75381 2 +Negative regulation of posttranscriptional gene silencing 0.6300412792415102 1.3173952829558306 0.1877061612543489 1.0 0.7495051946879028 6 O75844 1 +Positive regulation of pattern recognition receptor signaling pathway 0.5836395669568566 1.316041161223476 0.1881602277349583 1.0 0.7495051946879028 8 Q9NQC3,O75955 2 +Cerebellar cortex formation 0.6591830326558001 1.3150344866609815 0.1884983124364785 1.0 0.7495051946879028 5 P04062 1 +Regulation of production of small rna involved in gene silencing by rna 0.6292343011138368 1.3134829384081157 0.1890202663641158 1.0 0.7502065782020028 6 O75844 1 +Olfactory behavior 0.8890959925442642 1.3090750083653742 0.1905089438880205 1.0 0.7504855706252936 2 O76024 1 +Chemosensory behavior 0.8890959925442642 1.3090750083653742 0.1905089438880205 1.0 0.7504855706252936 2 O76024 1 +Regulation of phospholipase activity 0.5480639966121361 1.308809842107234 0.1905987722294488 1.0 0.7504855706252936 10 P50897,P35232,Q9Y263,Q99623 4 +Attachment of gpi anchor to protein 0.6577271435516453 1.3083727369935283 0.1907469150441156 1.0 0.7504855706252936 5 Q96S52,Q92643 2 +Ubiquitin dependent erad pathway 0.4318651331327047 1.305964113343582 0.1915647617652141 1.0 0.7507403184651013 35 Q8IXB1,O75477,P46379,Q9BUN8,O43765,P51572,O94905,O60858,P27824,Q96A33,Q6NTF9,Q9UBV2,Q9GZP9,Q96CS3,O76024 15 +Muscle cell development 0.4410523876952783 1.300534424496276 0.1934178656460938 1.0 0.7511624189443821 26 O75844,P10644,P02545,Q96TA1,P11413,P16615 6 +Neutrophil differentiation 0.749143740910567 1.299550711387395 0.1937550020589853 1.0 0.7511624189443821 4 Q8N5M9 1 +Regulation of t cell apoptotic process 0.655568203205319 1.2984911991395578 0.1941185986170759 1.0 0.7511624189443821 5 Q9HCL2 1 +Negative regulation of ion transport 0.4889195136625702 1.2980116005785012 0.1942833487084749 1.0 0.7511624189443821 15 Q96PU5,P21796,Q04656 3 +Nuclear envelope organization 0.4369284399132399 1.2954744733008694 0.19515660169625 1.0 0.7511624189443821 30 O75844,Q9ULX6,P02545,Q9BTV4,O94901,Q9UH99,P20700,P50402,Q9Y3E7,O14656,Q86XL3,Q8N1F7,Q9H6H4 13 +Cellular response to lipoprotein particle stimulus 0.7478763156064177 1.294287953405026 0.1955659759784382 1.0 0.7511624189443821 4 O15118 1 +Lipid translocation 0.7477363587737369 1.2937067939868845 0.195766717709205 1.0 0.7511624189443821 4 Q96AA3,Q7Z3C6 2 +Heparan sulfate proteoglycan biosynthetic process 0.6251455242500171 1.2936500143842398 0.1957863383849185 1.0 0.7511624189443821 6 Q7LGA3,Q96L58 2 +Heparan sulfate proteoglycan metabolic process 0.6251455242500171 1.2936500143842398 0.1957863383849185 1.0 0.7511624189443821 6 Q7LGA3,Q96L58 2 +Positive regulation of glycoprotein metabolic process 0.6022805151185753 1.2929633882183555 0.1960237220182321 1.0 0.7513004834642482 7 Q9H0U4,P62820,Q92542 3 +Protein localization to golgi apparatus 0.5558981218444105 1.2920428193695217 0.196342316261123 1.0 0.7513004834642482 9 P49755,Q8N2H4,Q96RL7 3 +Lipid biosynthetic process 0.4319945589041646 1.291658708326891 0.1964753630866302 1.0 0.7513004834642482 151 Q15392,Q9NX62,P35790,P30536,Q96N66,Q96G23,O15269,Q15800,Q9UKU0,Q10713,P05023,Q9NZ01,Q92604,Q8WTV0,O95674,Q92643,P28288,O75477,Q9BZF3,Q9BY49,Q9P035,Q13510,Q9NUQ2,Q9H7Z7,Q16850,O95470,Q9BVG9,P48651,Q9UBM7,Q86YH6,Q01968,P33121,P16435,Q16739,Q8NBQ5,Q6IAN0,Q14534,Q53GQ0,P04062,Q16880,Q96PE3,Q8NCG7,Q9UKR5,Q15125,Q9NTJ5,Q14739,O00767,Q9UG56,Q86YN1,Q9BTU6,P37268,Q9HCL2,Q8NBX0,Q9NPH0,Q96S52,P11413,P04035,O00116,Q53H12,O94905,Q8N5B7,O15228,P38398,Q5H8A4,P14324,Q06136,Q8NF37 67 +3 phosphoadenosine 5 phosphosulfate biosynthetic process 0.8847468157812937 1.291337738079816 0.196586590096913 1.0 0.7513004834642482 2 Q8TB61 1 +Regulation of sodium ion transmembrane transport 0.4826157819263486 1.2894372455312098 0.1972461199092654 1.0 0.7517468018977914 16 Q96PU5,P23634,P27105,Q12959 4 +Aspartate family amino acid metabolic process 0.4542300923722237 1.2893327118759716 0.1972824432639908 1.0 0.7517468018977914 21 O43175,Q9UJS0,O75746,Q9BQT8,Q13126 5 +Response to topologically incorrect protein 0.3925371569079159 1.2867528431702688 0.1981804481588374 1.0 0.7517468018977914 52 P48723,Q96HY6,Q15363,P46379,Q96HE7,Q9NRK6,P57088,Q9BUN8,O95140,O14656,Q9Y4P3,Q6NTF9,Q92905,Q9GZP9,Q96CS3,O76024 16 +Walking behavior 0.8739051614912627 1.2839833237631275 0.199147790431255 1.0 0.7526573541029657 3 O15118 1 +Detection of biotic stimulus 0.6513762286774551 1.2792954011975417 0.2007930514450107 1.0 0.7540704825907883 5 P30536,Q8WTV0 2 +Histone h4 k20 methylation 0.6512728429670879 1.2788218381883123 0.2009598018564173 1.0 0.7540704825907883 5 O96028,Q14166 2 +Chemical homeostasis 0.4555917738597488 1.2777471019289468 0.2013386114377906 1.0 0.7540704825907883 183 P06576,P52789,O00203,P30536,Q9NQC3,O75787,O43819,P05023,Q9Y6C9,P16615,Q8WTV0,Q96PU5,P50897,P98194,P09601,P30519,Q9P035,Q16891,P05067,P35670,O15118,O95202,O76024,Q04656,Q16739,P0CG08,Q15043,P04062,P61916,O75503,Q5BJF2,Q6P4Q7,Q9BWH2,P51790,Q8N5M9,Q96CP7,Q8N511,Q93050,P51572,Q9HCL2,Q9HD20,Q15904,Q9NP58,Q7L0J3,Q96A33,O75880,Q9Y487,O15254,Q96AQ8,Q8NF37 50 +Prenylation 0.8713019621768283 1.2739579073608007 0.202678334198602 1.0 0.7549559581307423 3 P49354 1 +Reactive oxygen species biosynthetic process 0.5419074355900968 1.2734689892079372 0.2028516700028864 1.0 0.7549559581307423 10 Q9BSK2,P51790 2 +Cellular response to biotic stimulus 0.4249537151875805 1.2729300237675532 0.2030428741354173 1.0 0.7549956806920767 37 Q8WTV0,O75844,Q9Y263,P04637,P30536,Q86UE4,Q96A33,P08670,Q9UM00,O76024 10 +Azole transmembrane transport 0.8800869835352522 1.2723510032747414 0.2032484344696505 1.0 0.7549956806920767 2 P30825 1 +Pyrimidine containing compound transmembrane transport 0.8800869835352503 1.2723510032747338 0.2032484344696532 1.0 0.7549956806920767 2 Q9BSK2 1 +Microtubule anchoring at microtubule organizing center 0.6196213877185622 1.2668301676878049 0.2052160226530157 1.0 0.7559284414020725 6 Q15154,Q9Y496,Q8TD16 3 +Microtubule anchoring 0.5183826452763355 1.2658070301116364 0.2055821775708759 1.0 0.7559284414020725 12 Q8TD16,Q15154,Q9Y496,O95684,Q9P287,O75381 6 +Regulation of protein exit from endoplasmic reticulum 0.5969283240078145 1.2657789145778862 0.2055922461032031 1.0 0.7559284414020725 7 P51572,Q9GZP9 2 +Circulatory system process 0.3526710641934416 1.2655540474146894 0.2056727868050887 1.0 0.7559284414020725 71 Q6P179,Q9Y289,P04899,P20020,O75787,P55011,P05023,Q9Y5X3,P16615,Q12959,Q96PU5,P09601,Q9UIQ6,P42892,P23634,O75844,Q9NZ08,P30825,P42785,Q9HB40,P10253 21 +Protein insertion into er membrane by stop transfer membrane anchor sequence 0.8691144494621988 1.2655354552254603 0.2056794469979825 1.0 0.7559284414020725 3 Q9NPA0 1 +Sterol homeostasis 0.5181051388471367 1.2641163726883244 0.2061882608530605 1.0 0.7559284414020725 12 P61916,O15118,Q8WTV0 3 +Regulation of retrograde protein transport er to cytosol 0.7402319536379027 1.2625427594355316 0.2067535501338995 1.0 0.7559284414020725 4 Q9GZP9 1 +Response to antibiotic 0.573317243669083 1.2611281299277624 0.2072626872155123 1.0 0.7559284414020725 8 P04637,Q04656 2 +Phosphatidylcholine acyl chain remodeling 0.8763591177384247 1.257175890094908 0.2086899516092215 1.0 0.7583532579222145 2 Q8NF37 1 +Regulation of systemic arterial blood pressure by hormone 0.8754271512892147 1.253384224927913 0.2100659096721053 1.0 0.7605770702924004 2 P42892 1 +Response to manganese ion 0.6166480363563731 1.2523838313138955 0.2104300350644234 1.0 0.7614060102081056 6 P05067,Q04656 2 +Positive regulation of leukocyte migration 0.4768509268570131 1.2502026253107987 0.2112255380518206 1.0 0.7621672738678714 16 Q5JRA6,Q8NE86,P05067,Q4KMQ2,Q08722 5 +Neurofilament cytoskeleton organization 0.8744951848400127 1.2495934369342143 0.2114481018186378 1.0 0.7625478887844895 2 P07196 1 +Regulation of reactive oxygen species biosynthetic process 0.5708560891872302 1.2480143307882627 0.2120258091370179 1.0 0.7633632365447197 8 Q9BSK2,P51790 2 +Carbohydrate transport 0.4657246772676163 1.2456060589392195 0.2129090568037333 1.0 0.7640279401006691 18 L0R6Q1,P52789,Q96AA3,Q6ZWJ1,P31751,O75298,Q9UKG1 7 +Protein retention in er lumen 0.8637324792400456 1.244822665830228 0.2131969426061741 1.0 0.7640279401006691 3 P24390 1 +Maintenance of protein localization in endoplasmic reticulum 0.8637324792400456 1.244822665830228 0.2131969426061741 1.0 0.7640279401006691 3 P24390 1 +Phosphatidylglycerol acyl chain remodeling 0.8720099409754547 1.2394890805407637 0.2151644301267317 1.0 0.7664509766049026 2 Q8NF37 1 +Positive regulation of monocyte chemotaxis 0.7340169019364807 1.2367324864010332 0.2161864138551927 1.0 0.7685710226194709 4 Q8NHP6,Q4KMQ2 2 +Inflammatory response 0.3480342477268086 1.236023032400518 0.2164500023979825 1.0 0.7686689561712432 69 Q9BXW9,Q4KMQ2,P51809,Q9UKG1,P53634,P09601,P14174,P05067,Q86UT6,Q6IAN0,P04062,P42785,Q8NCG7,P28070,Q9UNH7,Q8N2K0,Q99735,Q9H000,Q9Y263,Q04721,Q8IV08,Q08722,O00203 23 +Regulation of establishment of protein localization to mitochondrion 0.469415160373123 1.2341800056516627 0.217135836189463 1.0 0.770684305777642 17 O00165,Q9Y371 2 +Protein maturation 0.3442648792608913 1.230730325050658 0.2184237422423416 1.0 0.7725827492116076 66 P67812,O75844,Q9UG56,Q15392,P42892,Q92542,Q99797,Q92896,O75503,Q10713,P35670,O76024 12 +Regulation of response to endoplasmic reticulum stress 0.4463224368250181 1.229836627668499 0.2187582891719504 1.0 0.7725827492116076 21 O60313,Q96HY6,Q4ZIN3,P46379,P57088,P51572,Q04323,O76024 8 +Cilium or flagellum dependent cell motility 0.6403840965420273 1.2289130787556155 0.2191043972752675 1.0 0.7725827492116076 5 Q9GZT3,P23634,Q96RL7 3 +Regulation of triglyceride metabolic process 0.6401001450216848 1.2276108426609649 0.2195930896005795 1.0 0.7725827492116076 5 Q8NCG7,Q8WTV0 2 +Myeloid leukocyte mediated immunity 0.4729994938326212 1.2239380616705993 0.2209755938998105 1.0 0.7725827492116076 16 P09601 1 +Positive regulation of amino acid transport 0.7308806289064812 1.223709162540398 0.2210619619621576 1.0 0.7725827492116076 4 Q15041 1 +Ganglioside catabolic process 0.8582404603434455 1.2237016693117029 0.2210647897110393 1.0 0.7725827492116076 3 P17900 1 +Ganglioside metabolic process 0.8582404603434455 1.2237016693117029 0.2210647897110393 1.0 0.7725827492116076 3 P17900 1 +Aminoglycan catabolic process 0.7307420064627604 1.2231335663122405 0.2212792524601812 1.0 0.7725827492116076 4 P54802 1 +Glycosaminoglycan catabolic process 0.7307420064627604 1.2231335663122405 0.2212792524601812 1.0 0.7725827492116076 4 P54802 1 +Bone mineralization 0.565968695496459 1.2219515895838855 0.2217259344941569 1.0 0.7725827492116076 8 O75844,P20020 2 +Positive regulation of mitochondrial membrane potential 0.7304569750159685 1.221950051664626 0.2217265161112962 1.0 0.7725827492116076 4 Q8IWA4,P31751 2 +Protein import 0.3661056439985941 1.2205652421078623 0.2222506732233855 1.0 0.7725827492116076 87 O60830,O14925,P02545,P52292,O95831,Q99623,Q7Z4Q2,Q15388,P04637,Q8TEX9,Q9Y512,Q9NS69,O43615,P13473,O96008,P40855,O14737,O75381 18 +Regulation of t cell mediated cytotoxicity 0.7290136535917129 1.2159572695260783 0.2240012000829496 1.0 0.7725827492116076 4 P04439,O15400 2 +Positive regulation of t cell mediated cytotoxicity 0.7290136535917129 1.2159572695260783 0.2240012000829496 1.0 0.7725827492116076 4 P04439,O15400 2 +Regulation of steroid metabolic process 0.4766310795331412 1.2158432424752827 0.2240446425575208 1.0 0.7725827492116076 15 P16435,P30536,Q13510,P05023,Q9UBM7 5 +Cellular response to osmotic stress 0.521151280206744 1.2155666899789357 0.2241500296355842 1.0 0.7725827492116076 11 Q9BPX6,P30536,O95202 3 +Positive regulation of atp metabolic process 0.5865587629996152 1.2130293715371196 0.2251185911458231 1.0 0.7725827492116076 7 P05067,P00403 2 +Positive regulation of nucleotide metabolic process 0.5865587629996152 1.2130293715371196 0.2251185911458231 1.0 0.7725827492116076 7 P05067,P00403 2 +Intracellular sterol transport 0.5637705075669399 1.210220904939845 0.2261941385044878 1.0 0.7725827492116076 8 O15118 1 +Cardiac muscle cell differentiation 0.4756869270058785 1.2095139050516737 0.2264654722498593 1.0 0.7725827492116076 15 O75844 1 +Response to copper ion 0.5635410296152735 1.2089960038412813 0.2266643806445669 1.0 0.7725827492116076 8 P05067,P35670 2 +Chromosome organization involved in meiotic cell cycle 0.4706531626911669 1.2079180631541344 0.2270787808544809 1.0 0.7725827492116076 16 P46379,Q9BXW9,Q92791,Q9BTX1,Q15645 5 +Head morphogenesis 0.6073405108590232 1.207121525641878 0.2273853461771322 1.0 0.7725827492116076 6 O95470 1 +Regulation of cartilage development 0.6351693399445313 1.2049930095984984 0.2282060005103812 1.0 0.7725827492116076 5 Q92896 1 +Regulation of chondrocyte differentiation 0.6351693399445313 1.2049930095984984 0.2282060005103812 1.0 0.7725827492116076 5 Q92896 1 +Regulation of superoxide metabolic process 0.7263319643728938 1.2048237833732067 0.2282713364954096 1.0 0.7725827492116076 4 P04899 1 +Posttranslational protein targeting to endoplasmic reticulum membrane 0.5396313569845846 1.2010109481737965 0.2297469544921897 1.0 0.775739561226303 9 P46379,O43681,Q9UGP8,Q99442,Q7L5D6 5 +Lipid homeostasis 0.4253856238915731 1.1999948694516556 0.2301413330114361 1.0 0.7762353712602194 30 Q96CP7,Q9HCL2,Q9NQC3,P61916,Q5BJF2,Q9BWH2,O15254,O15118,Q8WTV0 9 +Regulation of sodium ion transport 0.4592016433303514 1.1993422842563657 0.2303948797061621 1.0 0.7766883289473261 18 Q96PU5,P23634,P27105,P05023,Q12959 5 +Positive regulation of i kappab kinase nf kappab signaling 0.4113536465555824 1.197496224536586 0.23111319824645 1.0 0.7769873095400518 40 P09601,Q8TB61,O60858,Q969V5,Q9Y3E0,O43657 6 +Digestive system process 0.5177078094054134 1.1951374843911078 0.232033318763253 1.0 0.7793878314105556 11 Q16739 1 +Phosphatidylglycerol biosynthetic process 0.8499365880406038 1.1918021703605943 0.2333388245825043 1.0 0.7813551488461957 3 Q9HCL2 1 +Negative regulation of smooth muscle cell proliferation 0.6319980734133712 1.19044248445752 0.2338725232991079 1.0 0.7822549996778585 5 P09601 1 +Nerve development 0.5599064655237483 1.1895887143325694 0.2342080837358857 1.0 0.7822549996778585 8 Q9H061 1 +Hormone transport 0.4229243752415997 1.187744984364005 0.2349338951507882 1.0 0.7829340429222311 31 Q8NE86,P62820,P53985,Q96TA1,P50416,Q9BRT2,Q9UNH7,P40939,Q92543,Q16836,Q8N5M9 11 +Protein hexamerization 0.6020187206639047 1.181219321627082 0.2375156075359594 1.0 0.7880484726855344 6 Q8TDW0,O95202 2 +Magnesium ion homeostasis 0.846847782898258 1.179948920407768 0.2380205312167547 1.0 0.7880547177361155 3 Q6P4Q7 1 +Membrane raft organization 0.5356363397720367 1.1785991623770795 0.2385578253418234 1.0 0.7880547177361155 9 P50897,O75955,O15118 3 +Regulation of mitochondrial fusion 0.601455462091453 1.1784770799303683 0.2386064645133763 1.0 0.7880547177361155 6 Q969V5,Q8N2A8 2 +Negative regulation of production of mirnas involved in gene silencing by mirna 0.7196599068125584 1.1771319183282796 0.2391428571331681 1.0 0.7889963556958988 4 O75844 1 +Retina development in camera type eye 0.4660439860490984 1.1764079447277362 0.2394318985094146 1.0 0.7889963556958988 16 Q16706,Q8NBN7,Q99471,P54802,P20020,Q8NF37 6 +Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress 0.4819837908112578 1.175703238802627 0.2397134839346892 1.0 0.7890097765068512 14 O60313,O95831,P46379,Q96HE7,P04637,O76024 6 +Phosphatidylinositol biosynthetic process 0.4247958543598404 1.175021958689871 0.2399859307938081 1.0 0.7890097765068512 27 Q5H8A4,Q9BTU6,Q9NX62,Q96N66,Q96S52,Q01968,Q96PE3,Q10713,Q9H490,Q9NTJ5,O14735,Q92643 12 +Positive regulation of small gtpase mediated signal transduction 0.5564395463772539 1.1710655287288811 0.2415724384754818 1.0 0.7922262295019199 8 Q15555,Q96AG4 2 +Meiotic chromosome segregation 0.4438885532560406 1.1678864183805615 0.2428525832399768 1.0 0.7930046217188492 20 P46379,Q9BXW9,Q92791,Q9BZD4,Q9BTX1,Q15645 6 +Developmental maturation 0.3912342130756241 1.167093412825557 0.2431726477380653 1.0 0.7930046217188492 48 Q8N2A8,P07196,Q9NZJ7,P05067,O75787,P04062,Q12768,O75503,Q15645,Q15125,Q92543,P51790 12 +Regulation of protein targeting 0.4235357266439399 1.164777668553699 0.2441090005110768 1.0 0.7930046217188492 27 O00165,Q9Y371,P55786,P27105,P31751,O14737,Q99828 7 +Establishment of protein localization to endoplasmic reticulum 0.4377053956764479 1.1647426503148168 0.2441231792639786 1.0 0.7930046217188492 21 P61026,P46379,O43681,Q9Y5M8,Q9UGP8,Q99442,Q7L5D6,Q15005 8 +Rhythmic behavior 0.6260917945983242 1.1633380213698994 0.244692385132081 1.0 0.7930716723143614 5 P54802 1 +Female meiotic nuclear division 0.5326776297568074 1.1619895051887854 0.2452397279350719 1.0 0.7930716723143614 9 Q12768 1 +Polyol metabolic process 0.4246390704076641 1.160555517635705 0.2458227039796567 1.0 0.7937596700843451 24 P04062,Q13510,Q9NX62,O15269 4 +Cellular response to inorganic substance 0.4072395402678015 1.1602673621694617 0.2459399684062964 1.0 0.7937596700843451 40 Q6NUK1,P09601,O95831,Q14168,Q92542,P30536,Q9NP58,P05067,Q04656 9 +Regulation of aerobic respiration 0.4794539612971682 1.1592436699219906 0.2463568755227918 1.0 0.7940180989583914 14 P14406,Q9BSK2,O14548 3 +Maintenance of protein location in mitochondrion 0.8412544511483588 1.1585041518228352 0.2466583583453367 1.0 0.7945034064803058 3 P52789 1 +Acylglycerol homeostasis 0.8404369952194708 1.155372295318569 0.2479380020970136 1.0 0.7974420778557284 3 Q8WTV0 1 +T cell mediated cytotoxicity 0.5964211190333607 1.153962166064555 0.2485156803840167 1.0 0.7976759568394093 6 P04439,O15400,Q9NUQ9 3 +Positive regulation of small molecule metabolic process 0.4623487858409556 1.1511102794055734 0.2496868695890153 1.0 0.7987281835133874 16 P16435,O75746,P00403,P05067,P50416,Q92604 6 +Regulation of nitric oxide synthase activity 0.6226162025072436 1.147386748877374 0.2512218153475594 1.0 0.8021905918662778 5 P23634,P06280,Q8WTV0 3 +Mitochondrial adp transmembrane transport 0.8380981976382782 1.146415218387549 0.2516233887668784 1.0 0.8021905918662778 3 P12235,P12236 2 +Nucleobase transport 0.8380981976382734 1.1464152183875305 0.2516233887668859 1.0 0.8021905918662778 3 P12235,Q9Y277 2 +Positive regulation of mitophagy 0.8380981976382663 1.1464152183875032 0.2516233887668972 1.0 0.8021905918662778 3 P12235,P21796 2 +Organic hydroxy compound catabolic process 0.4772572103820056 1.1449416610786112 0.252233324640537 1.0 0.8031815329742924 14 Q9NX62,P21964,Q8WTV0 3 +Ribonucleoside triphosphate metabolic process 0.410299556271732 1.1441562377064207 0.2525588483849763 1.0 0.8031815329742924 37 O60313,P06576,Q8IWA4,Q9UJS0,P56385,P24539,P00403,Q9UIJ7,O75964 9 +Amelogenesis 0.8477788132960513 1.141370794068317 0.2537156531318534 1.0 0.8045034317661933 2 Q6P4Q7 1 +Tooth mineralization 0.8477788132960513 1.141370794068317 0.2537156531318534 1.0 0.8045034317661933 2 Q6P4Q7 1 +Enamel mineralization 0.8477788132960513 1.141370794068317 0.2537156531318534 1.0 0.8045034317661933 2 Q6P4Q7 1 +Regulation of type i interferon mediated signaling pathway 0.4756533733153272 1.134494551503355 0.2565871579187746 1.0 0.8083453006398917 14 Q14166 1 +Neutral lipid metabolic process 0.4597662215141211 1.1334123495081772 0.2570411303972864 1.0 0.8083453006398917 16 Q9HCL2,Q96N66,Q9NUQ2,Q8NCG7,Q9UBV2,Q92604,Q8WTV0 7 +Positive regulation of cell aging 0.7089039699120443 1.1325276975221803 0.2574126465901587 1.0 0.8083453006398917 4 P02545 1 +Neuromuscular process controlling balance 0.4854744564040518 1.128354015094266 0.259170440050223 1.0 0.8083453006398917 13 P10253,P05067,P17900,P07196 4 +Aspartate transmembrane transport 0.8331261653200756 1.12739099839998 0.2595772032549202 1.0 0.8083453006398917 3 O75746,Q9UJS0 2 +Adipose tissue development 0.5063079551157542 1.1273850838350454 0.2595797028398539 1.0 0.8083453006398917 11 O15173,Q6IAN0,Q6KCM7,P43490 4 +Maintenance of protein localization in organelle 0.4539355702335041 1.1262642609760043 0.2600536804717115 1.0 0.8083453006398917 17 P24390,O15258,P52789,Q9UH99 4 +Growth plate cartilage development 0.8318414789080373 1.122479574437079 0.2616585874014134 1.0 0.8084164230103902 3 O75844 1 +Bone growth 0.8318414789080373 1.122479574437079 0.2616585874014134 1.0 0.8084164230103902 3 O75844 1 +Nervous system process 0.3701345841664835 1.1218099292398138 0.2619432635592638 1.0 0.8084164230103902 99 O60313,P07196,Q92542,Q99797,O14773,Q92696,P50897,P17900,Q9Y5J9,Q14168,P05067,O76024,O75844,P04062,Q6P4Q7,Q9Y6M9,Q14108,Q9H6K4,Q13641,O75746,P10253,P04035,O00264,Q08257,Q9BPW8,O75915 26 +Nuclear pore complex assembly 0.5252963366687146 1.1205159388778303 0.2624939642936015 1.0 0.8084164230103902 9 Q9NQC3 1 +Fibroblast migration 0.4735083422926698 1.1205156190878738 0.2624941004896304 1.0 0.8084164230103902 14 O95470 1 +Activation of protein kinase c activity 0.8421870146008001 1.1188510469857862 0.2632036900132801 1.0 0.8084164230103902 2 Q99623 1 +Negative regulation of lymphocyte mediated immunity 0.7055014618171064 1.1184308376591654 0.2633830299072177 1.0 0.8084164230103902 4 P04439,Q96FV9 2 +Membrane repolarization 0.5244127053017538 1.115548062029869 0.2646156346505637 1.0 0.8100251279812875 9 O75844,Q96PU5 2 +Pigment granule localization 0.7047801690683755 1.1154434377644664 0.2646604440878519 1.0 0.8100251279812875 4 P62820,Q13561 2 +Regulation of lipid biosynthetic process 0.417882482908485 1.113984993748156 0.2652856244462804 1.0 0.8115571968147602 26 P16435,Q8NF37,P30536,O94905,Q13510,P05023,Q9UBM7,Q92604,Q8WTV0 9 +Positive regulation of smooth muscle cell proliferation 0.5438929089332493 1.10396121211482 0.2696099637689397 1.0 0.8179414526992116 8 O95140,P35232,P09601 3 +Morphogenesis of a branching structure 0.4547068928061658 1.0987037728697004 0.2718972963703003 1.0 0.8179414526992116 16 Q9NQC3,Q15363 2 +Insulin secretion 0.4164607712019217 1.0985250054800106 0.2719753048333468 1.0 0.8179414526992116 25 Q8NE86,P53985,P50416,Q9BRT2,P40939,Q92543,Q16836,Q8N5M9 8 +Regulation of nitric oxide metabolic process 0.5014473833434027 1.098451395596797 0.2720074303229465 1.0 0.8179414526992116 11 Q08722,P30536,P06280 3 +Respiratory gaseous exchange by respiratory system 0.5109704846732378 1.0950126946524894 0.2735110749696581 1.0 0.8179414526992116 10 P10253,Q7KZN9,O00203 3 +Response to corticosterone 0.8356632494563502 1.0926477510006425 0.274548488484809 1.0 0.8179414526992116 2 P07196 1 +Regulation of vasoconstriction 0.8356632494563443 1.0926477510006194 0.274548488484819 1.0 0.8179414526992116 2 P42892 1 +Cell migration involved in sprouting angiogenesis 0.5198977948253979 1.0901567477114815 0.2756441023553231 1.0 0.8179414526992116 9 Q5JRA6,P09601 2 +Transepithelial chloride transport 0.8350419384902061 1.090156356805255 0.2756442745207321 1.0 0.8179414526992116 2 P51798 1 +Positive regulation of bone mineralization 0.8232770665182608 1.089784512572392 0.2758080777542564 1.0 0.8179414526992116 3 P20020 1 +Plasma membrane phospholipid scrambling 0.8347312830071408 1.0889109402621298 0.2761931613055637 1.0 0.8179414526992116 2 Q7Z3C6 1 +Negative regulation of cell volume 0.8347312830071376 1.0889109402621169 0.2761931613055695 1.0 0.8179414526992116 2 P51790 1 +Cellular hyperosmotic response 0.6098372263004591 1.0887475966362703 0.2762652062516579 1.0 0.8179414526992116 5 O95202 1 +Response to arsenic containing substance 0.4891918285354536 1.0872285436520368 0.2769358191229982 1.0 0.8179414526992116 12 P09601 1 +Cholesterol efflux 0.5407338284969109 1.0870533437333476 0.277013235523138 1.0 0.8179414526992116 8 P61916,O15118,Q8WTV0 3 +Regulation of defense response 0.3601781315017926 1.086879466148221 0.2770900821965831 1.0 0.8179414526992116 92 Q9BXW9,Q6UWE0,O43657,P23246,P04439,Q8WXF1,P05067,Q86UT6,O75844,P11279,Q9NZ08,P04062,Q14166,Q969V5,Q8NCG7,Q9NUD5,Q9UNH7,Q8IZ81,Q8N2K0,Q99735,Q9H000,Q08722 22 +Peptidyl proline hydroxylation 0.5617101641630348 1.086342715235971 0.2773273954362074 1.0 0.8179414526992116 7 Q96HE7,P13674,P07237,O15460,Q32P28 5 +Endocrine process 0.6973377785948245 1.0846416342457494 0.278080407495525 1.0 0.8191486630566958 4 P42892,O75787 2 +Intermembrane lipid transfer 0.5394651398823321 1.0802623589098894 0.2800253664706718 1.0 0.8195960197356582 8 P61916,Q9NZD2,P30536 3 +Hyperosmotic response 0.5603770088981541 1.0795407880241712 0.2803467211932811 1.0 0.8195960197356582 7 Q9BPX6,O95202 2 +Membrane protein proteolysis 0.4982432129447424 1.0793663153111466 0.2804244609673767 1.0 0.8195960197356582 11 Q9NZ08,O43847,Q8TCT8,Q92542 4 +Calcium ion regulated exocytosis 0.5177863733643013 1.0782784943926138 0.2809094913733791 1.0 0.8195960197356582 9 Q68EM7,P04899,Q9BRK5,P16615 4 +Phosphatidylinositol metabolic process 0.4107456436174608 1.0780739537234263 0.2810007541946453 1.0 0.8195960197356582 30 Q5H8A4,Q9BTU6,Q9NX62,Q96N66,Q96S52,Q01968,Q96PE3,Q6UWP7,Q10713,Q9H490,Q9NTJ5,O14735,Q92604,Q92643 14 +Regulation of potassium ion export across plasma membrane 0.8316247281764533 1.076467251759827 0.281718339315572 1.0 0.8202197335549041 2 Q4KMQ2 1 +Potassium ion export across plasma membrane 0.8316247281764533 1.076467251759827 0.281718339315572 1.0 0.8202197335549041 2 Q4KMQ2 1 +Positive regulation of mononuclear cell migration 0.5076064855749156 1.0755474422038749 0.2821297036958536 1.0 0.8206836802907971 10 P05067,Q08722,Q4KMQ2 3 +Regulation of tube size 0.4975301670907381 1.0751181233892984 0.28232184636261 1.0 0.8208759756069995 11 Q9HB40 1 +Response to corticosteroid 0.4136768017682432 1.073034792962234 0.2832555056800387 1.0 0.8221225973681339 24 P16435,P16278,O95831,P07196,P35573,P04062 6 +Cytokine mediated signaling pathway 0.3859465397984065 1.0709035922406898 0.2842127805010717 1.0 0.8225232407398959 46 Q16739,P04637,Q8TCT8,Q14166,Q969V5,Q8N5M9 6 +Negative regulation of vascular endothelial growth factor receptor signaling pathway 0.6938141125272028 1.0700743880161356 0.2845858265202425 1.0 0.8225232407398959 4 P18031,O14964,Q96TA1 3 +Regulation of response to osmotic stress 0.6936919265668431 1.0695694631602184 0.2848131465371248 1.0 0.8225232407398959 4 O95202 1 +Positive regulation of endocytosis 0.4358805682176439 1.0692332721550044 0.284964569722903 1.0 0.8225232407398959 19 Q96PU5,P50897,Q8NBU5,O14656,P50570,Q4KMQ2,O75955,Q9UKG1 8 +Negative regulation of muscle hypertrophy 0.6054559458116249 1.0686537822512665 0.2852257045250823 1.0 0.8225232407398959 5 P02545,P23634 2 +Anatomical structure maturation 0.4030245066670156 1.0677295474800317 0.2856425260184634 1.0 0.8225232407398959 36 Q8N2A8,Q9NZJ7,P04062,P05067,O75787,Q12768,O75503,Q15645,Q15125 9 +Entry of bacterium into host cell 0.6929628809158567 1.0665570319491156 0.2861719121014285 1.0 0.8225232407398959 4 Q9BTY2 1 +Maternal process involved in female pregnancy 0.5576018322720638 1.0653816456472018 0.2867032592012672 1.0 0.82368695508507 7 Q15363 1 +Neural nucleus development 0.4494975116966552 1.0629201324536244 0.2878181722332276 1.0 0.8241464318808085 16 P24539,Q16352 2 +Negative regulation of immune effector process 0.495052205798807 1.060352298536937 0.2889843548161426 1.0 0.8248251809848652 11 P04439,Q08722,P09601 3 +Negative regulation of cardiac muscle adaptation 0.8275862068965402 1.0603199010819333 0.2889990884396534 1.0 0.8248251809848652 2 P02545 1 +Negative regulation of muscle adaptation 0.8275862068965402 1.0603199010819333 0.2889990884396534 1.0 0.8248251809848652 2 P02545 1 +Positive regulation of leukocyte degranulation 0.6912392114353534 1.059436874389594 0.2894008637417198 1.0 0.8253763392054674 4 P11279 1 +Retrograde transport endosome to golgi 0.404544144565171 1.059338480178809 0.2894456561869012 1.0 0.8253763392054674 34 Q9BVK6,O15498,O60499,Q8NBN3,O75503,O95249,Q9UNH7,Q9Y5X3,O60749 9 +Membrane protein intracellular domain proteolysis 0.8151025481665475 1.0586627516750569 0.2897533972949129 1.0 0.8255310046289447 3 Q8TCT8,Q92542 2 +Negative regulation of neuron death 0.3959642575343767 1.0578321768476655 0.2901319604166847 1.0 0.825871093626815 40 P50897,P09601,Q4ZIN3,P04062,O76024 5 +Terpenoid metabolic process 0.434280674527168 1.0575663823692227 0.2902531756965729 1.0 0.825871093626815 19 Q9HB40,Q9Y394,Q8NBN7,P37268,P51648 5 +Response to retinoic acid 0.4637443602893029 1.056803224526908 0.2906014023868146 1.0 0.8265008444302724 14 Q9P0J0,Q8TB36,Q99623 3 +Methionine metabolic process 0.6026602126398056 1.055836504549728 0.2910429172560365 1.0 0.8266993990090984 5 Q13126 1 +Positive regulation of blood circulation 0.8140838756927645 1.0547908880973558 0.2915209728594021 1.0 0.8266993990090984 3 P16615 1 +Pyramidal neuron development 0.8140118060178461 1.054517015389126 0.2916462745806323 1.0 0.8266993990090984 3 O14949 1 +Response to ischemia 0.5039177369111496 1.0541960606847405 0.2917931632279551 1.0 0.8266993990090984 10 P04637,O95831,P52789 3 +Maintenance of location in cell 0.3921025835914861 1.054109398394653 0.2918328337542346 1.0 0.8266993990090984 42 P52789,Q9UH99,P24390,P10253,O15258,P35670,Q96RL7,O95202 8 +Cellular modified amino acid catabolic process 0.513449377950595 1.053874188520301 0.2919405216829305 1.0 0.8266993990090984 9 Q9UHG3 1 +Regulation of cardiac conduction 0.6019189869523531 1.0524390185070227 0.2925981749471007 1.0 0.8267759027354568 5 P20020,P16615 2 +Negative regulation of intracellular estrogen receptor signaling pathway 0.6017908424562537 1.0518516876748985 0.2928676004664525 1.0 0.8267759027354568 5 Q99623 1 +Lung alveolus development 0.6879164779369401 1.0457199409003406 0.2956903533997321 1.0 0.8267759027354568 4 Q04656 1 +Regulation of phospholipase c activity 0.8116842759477932 1.0456762159714603 0.2957105473851023 1.0 0.8267759027354568 3 P35232,Q99623 2 +Activation of phospholipase c activity 0.8116842759477932 1.0456762159714603 0.2957105473851023 1.0 0.8267759027354568 3 P35232,Q99623 2 +Positive regulation of anion transport 0.5537349457980385 1.0456541186634432 0.2957207531895121 1.0 0.8267759027354568 7 Q15041,P55011,P14174 3 +Regulation of neurotransmitter uptake 0.6003769734423434 1.045372104918722 0.2958510240238143 1.0 0.8267759027354568 5 O75955 1 +Process utilizing autophagic mechanism 0.4205612132016207 1.0438406064561856 0.296559141041657 1.0 0.827544852444007 163 Q86Y82,P52789,P05141,P30536,Q9Y296,Q07820,O15269,P10619,Q6UWE0,Q9Y5X3,Q5T8D3,P16615,Q96RL7,P07602,P09601,Q86UE4,P21796,Q9NRR5,O15118,O75844,Q969Q5,Q15382,P04632,P62820,Q99623,Q9Y6I9,Q9Y371,P04062,Q969V5,Q9BWH2,Q7Z3C6,Q9UNH7,O14681,O60858,P20073,Q96HY6,Q93050,Q9Y263,O95140,O00165,P04637,Q9NZJ7,Q9Y487,P13473,P12235 45 +Regulation of amyloid fibril formation 0.5732050580977555 1.0408825669606812 0.2979300535141793 1.0 0.8284845148749741 6 P05067,Q9UHV9,Q99471 3 +Cell death in response to oxidative stress 0.4319214761285017 1.0403538251488396 0.2981755458621784 1.0 0.8284845148749741 19 P23246,P07237,Q15233,P04062,Q969S3,Q07820,Q99720,O75915 8 +Positive regulation of proteolysis 0.3489803317079799 1.0384549008569404 0.2990583212436997 1.0 0.8287219425720249 85 Q9P0J0,Q96HY6,O95831,Q4ZIN3,P46379,Q9UL46,P61289,P51572,Q92542,Q9NZJ7,P04062,P05067,Q96A26,Q969V5,P54725,O14737,Q9Y5A7 17 +Negative regulation of endoplasmic reticulum calcium ion concentration 0.6858462693754964 1.037179800627083 0.2996520700185763 1.0 0.8287219425720249 4 P51572 1 +Positive regulation of monooxygenase activity 0.5984668550148156 1.036620343496515 0.2999128285135797 1.0 0.8287219425720249 5 Q04656,Q8WTV0 2 +Cerebellar cortex morphogenesis 0.5715705884007709 1.0329259927651075 0.301638533675308 1.0 0.8302375679584499 6 P04062 1 +Regulation of fatty acid biosynthetic process 0.5506195982922574 1.029763353760714 0.3031211073744588 1.0 0.8302375679584499 7 P38398,Q92604,O75477,O94905 4 +Establishment of pigment granule localization 0.8198198198198102 1.0293671543064438 0.3033071775887084 1.0 0.8302375679584499 2 Q13561 1 +Calcium mediated signaling 0.4245252178311701 1.0239320496221025 0.3058673709637416 1.0 0.8302375679584499 20 O75844,Q8NE86,P51572,P23634,Q99828,P16615 6 +Myeloid cell activation involved in immune response 0.4986046685433458 1.023434381979196 0.3061025101110683 1.0 0.8302375679584499 10 Q9UNH7,Q99584,P09601 3 +Interleukin 6 production 0.4583251929522084 1.021397359353052 0.3070662159219925 1.0 0.8302375679584499 14 P04062,Q08722,P05067 3 +Positive regulation of lipid catabolic process 0.8051584835301357 1.020932959167622 0.3072862024164435 1.0 0.8302375679584499 3 Q8NCG7,P50416 2 +Leukocyte migration 0.3741085316081354 1.0209131070974673 0.3072956086726255 1.0 0.8302375679584499 49 Q8NE86,P84095,P09601,Q5JRA6,Q8NHP6,P05067,P04062,P55011,Q4KMQ2,Q08722,P35613,Q8N5M9 12 +Glycosyl compound catabolic process 0.4980005183062183 1.0199361179134965 0.307758758700285 1.0 0.8302375679584499 10 Q13126,P04062,Q9NUJ1,P16260 4 +Pirna metabolic process 0.8173345759552554 1.019491749674657 0.3079695680100682 1.0 0.8302375679584499 2 Q8N2A8 1 +Positive regulation of mitochondrial fission 0.4978209511856103 1.0188963481806257 0.3082521775849618 1.0 0.8302375679584499 10 Q8NE86,Q969V5,Q9NX47 3 +Coenzyme a metabolic process 0.4976177884870166 1.0177199471131233 0.3088110649850046 1.0 0.8302375679584499 10 Q8WVC6,P16260 2 +Response to lead ion 0.5938388067455838 1.0154267521070963 0.3099024461428645 1.0 0.8311253592966261 5 P05067 1 +Response to steroid hormone 0.3291831968921779 1.014420648884828 0.3103820754562316 1.0 0.8312164709894888 64 P16435,P16278,Q96HY6,O95831,P07196,Q99623,P35573,P30536,P38398,P04062,P05023,O15173,P35232,O15118 14 +Negative regulation of growth 0.4013355041968361 1.0138156172031398 0.3106707418507137 1.0 0.8312975302216652 32 Q9P0J0,P50897,P04637,Q9NQC3,Q969V5,Q15375,O14681,P35232 8 +Isoprenoid metabolic process 0.4050629456409382 1.0099325226848033 0.3125276196739923 1.0 0.8319492815608923 26 Q9HB40,Q9Y394,Q8NBN7,P37268,P61916,P04035,P51648 7 +Regulation of cellular respiration 0.4371879761890818 1.008951515669064 0.3129978871657624 1.0 0.8319492815608923 17 P14406,Q9BSK2,O14548 3 +Negative regulation of viral induced cytoplasmic pattern recognition receptor signaling pathway 0.59203498303176 1.0071711661971303 0.3138525266913312 1.0 0.8325005060456705 5 O43657 1 +Negative regulation of synapse organization 0.8142280211245615 1.007168722064595 0.3138537010277851 1.0 0.8325005060456705 2 O00264 1 +Odontogenesis of dentin containing tooth 0.5255278341845263 1.005655661102962 0.31458123878945 1.0 0.8336148307974734 8 Q6P4Q7,P35613 2 +Cardiolipin metabolic process 0.5458820322013805 1.0056053619272558 0.3146054435897727 1.0 0.8336148307974734 7 P40939 1 +Lymphocyte activation 0.3584213197276574 1.004650960203319 0.3150649495968338 1.0 0.8341536653350321 97 P46379,Q9BXW9,Q9NQT5,P05141,Q92542,Q5HYI8,Q12959,P10644,P24390,P04439,O96028,Q04656,Q9NUQ9,P11279,P0CG08,Q99623,P30825,P04062,O96005,P55327,Q96L92,P49366,P04637,Q9HCL2,Q08722,P35232,Q96FV9,O00203 28 +Signaling receptor ligand precursor processing 0.799564947172149 0.9997799309982732 0.3174170200932287 1.0 0.8382424615903065 3 P42892,O75787 2 +Peripheral nervous system axon regeneration 0.676550855134127 0.9988986179591234 0.3178438058044097 1.0 0.8382504919175651 4 Q96G23,P07196 2 +Mitochondrial proton transporting atp synthase complex assembly 0.810500155327729 0.9924134143677732 0.3209958979083764 1.0 0.841528196314191 2 Q15070 1 +Sodium ion export across plasma membrane 0.7971772163023694 0.9907669640814412 0.321799384101489 1.0 0.8425274280845673 3 P05023 1 +Regulation of anion transmembrane transport 0.5626111017959412 0.9893402851465308 0.3224966802110895 1.0 0.8425274280845673 6 Q15041 1 +Negative regulation of organic acid transport 0.7964574269732768 0.9880520142935922 0.3231271749314719 1.0 0.8428223028949445 3 O75915,P31751 2 +Endosome organization 0.3982372608456235 0.9874349083110556 0.3234294782423972 1.0 0.8431474940695199 32 Q14108,Q12768,Q96ED9 3 +Cellular hyperosmotic salinity response 0.6731540919454725 0.984939169639002 0.3246539517337692 1.0 0.8444373752564053 4 O95202 1 +Cellular response to salt stress 0.6731540919454725 0.984939169639002 0.3246539517337692 1.0 0.8444373752564053 4 O95202 1 +Hyperosmotic salinity response 0.6731540919454725 0.984939169639002 0.3246539517337692 1.0 0.8444373752564053 4 O95202 1 +Export across plasma membrane 0.4914693811695341 0.9821187178343224 0.3260413651076979 1.0 0.8466480978526729 10 P20020,Q4KMQ2,P05023,P35670,Q12959 5 +Vesicle organization 0.3510608832306474 0.976385160912183 0.328873632255293 1.0 0.8498376073066625 92 Q86Y82,Q15363,Q9NR31,Q96ED9,Q9UNK0,Q9HCU5,Q12768,O95249,Q5JRA6,P62820,O60499,O15400,Q14108,Q92543,P51790,Q9BVK6,P49755,Q9BTU6,O75396,Q9NP58,Q9BZG1,P31751,O00203 23 +Mitochondrial dna repair 0.6709968943970603 0.9760829067012968 0.3290233812649989 1.0 0.8498376073066625 4 P49916,P04637 2 +Copper ion transport 0.7930287542712671 0.975132867247689 0.3294943570989899 1.0 0.8505570455328852 3 P35670 1 +Cellular response to vitamin 0.6698197709924989 0.971253375733202 0.3314221201319252 1.0 0.850774636798986 4 Q8TB36 1 +Post translational protein modification 0.4799773985402663 0.9704774467233688 0.3318085613838888 1.0 0.850774636798986 11 O60725 1 +Positive regulation of fatty acid beta oxidation 0.8049083566324908 0.9703498989316468 0.3318721127459625 1.0 0.850774636798986 2 P50416 1 +Positive regulation of fatty acid oxidation 0.8049083566324908 0.9703498989316468 0.3318721127459625 1.0 0.850774636798986 2 P50416 1 +Response to light intensity 0.8049083566324886 0.970349898931638 0.3318721127459669 1.0 0.850774636798986 2 Q8NBN7 1 +Cellular carbohydrate catabolic process 0.4356836780852938 0.967875201239625 0.3331067007425159 1.0 0.850774636798986 16 P10253,P04637,Q9NUJ1,Q14108 4 +Regulation of potassium ion import 0.7909026746741202 0.9671332541641672 0.3334774234427173 1.0 0.850774636798986 3 Q12959 1 +Regulation of erad pathway 0.5383272748448575 0.9671100484072448 0.3334890227675722 1.0 0.850774636798986 7 P51572,Q4ZIN3,Q04323 3 +Photoreceptor cell development 0.6687810973990692 0.966993741790266 0.3335471621874522 1.0 0.850774636798986 4 Q8NBN7,P54802 2 +Peptidyl proline hydroxylation to 4 hydroxy l proline 0.5825932938318794 0.9640129245392324 0.3350394461204726 1.0 0.850774636798986 5 O15460,P13674,Q96HE7 3 +Negative regulation of steroid metabolic process 0.7899316345556194 0.9634825930696078 0.3353053955033296 1.0 0.850774636798986 3 P05023,O94905 2 +Estrogen metabolic process 0.5572869796968501 0.963470610067178 0.3353114062816713 1.0 0.850774636798986 6 O95470,Q53GQ0 2 +Iron coordination entity transport 0.7895476094668927 0.962039361151676 0.3360298323259711 1.0 0.850774636798986 3 O15173 1 +Heme transport 0.7895476094668927 0.962039361151676 0.3360298323259711 1.0 0.850774636798986 3 O15173 1 +Positive regulation of protein exit from endoplasmic reticulum 0.6668886752517502 0.9592374609369032 0.3374391326806152 1.0 0.850774636798986 4 P51572,Q9NR31 2 +Response to osmotic stress 0.4255128111309229 0.9588378671052116 0.3376404295210591 1.0 0.850774636798986 18 P04637,P30536,P55011,Q9BPX6,O95202 5 +Nuclear pore organization 0.4578992542873568 0.9538016673681496 0.3401840452539755 1.0 0.8547911600073852 13 Q9NQC3,Q8NFH5,Q9BTX1 3 +Positive regulation of carbohydrate metabolic process 0.5155415177465763 0.9522376973871974 0.3409764466746203 1.0 0.8556519579770756 8 O75746,P05067 2 +Regulation of t cell activation 0.3885109029249877 0.9510223162427046 0.3415930474742956 1.0 0.8556519579770756 37 P10644,Q9BXW9,O00203,P04439,Q12959,Q9HCL2,P30825,O96005,Q08722,Q9NUQ9 10 +Regulation of ossification 0.4856873722242609 0.9486479506898606 0.3427996945484515 1.0 0.8556519579770756 10 O75844,P20020 2 +Pigmentation 0.4284730220824972 0.9477734557465116 0.34324479651196 1.0 0.8556519579770756 17 P62820,Q9NP58,O75787,Q13561,Q04656,O00203 6 +Nonribosomal peptide biosynthetic process 0.5787471706134046 0.9464626571890238 0.3439126602380606 1.0 0.8556519579770756 5 Q9UJ14 1 +Cellular response to extracellular stimulus 0.3836943614706137 0.9458181899862113 0.3442413261364099 1.0 0.8556519579770756 40 P09601,Q9Y371,Q9Y4P3,P04062,P13473,P21964 6 +Regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 0.5340362669515575 0.94526672270582 0.3445227229682848 1.0 0.8556519579770756 7 Q969V5 1 +Mitochondrial dna replication 0.4940361106696594 0.9446346924825164 0.3448454090412762 1.0 0.8556519579770756 9 P49916,Q9UJZ1,Q96QE5,Q96EY1,P51530 5 +G protein coupled acetylcholine receptor signaling pathway 0.7977632805219015 0.9422868395491032 0.3460458041727028 1.0 0.8556519579770756 2 P50148 1 +Regulation of adenylate cyclase activating g protein coupled receptor signaling pathway 0.7977632805219003 0.9422868395490984 0.3460458041727052 1.0 0.8556519579770756 2 P23634 1 +Adenylate cyclase activating adrenergic receptor signaling pathway involved in heart process 0.7977632805219003 0.9422868395490984 0.3460458041727052 1.0 0.8556519579770756 2 P23634 1 +Negative regulation of adenylate cyclase activating adrenergic receptor signaling pathway 0.7977632805219003 0.9422868395490984 0.3460458041727052 1.0 0.8556519579770756 2 P23634 1 +Negative regulation of adenylate cyclase activating g protein coupled receptor signaling pathway 0.7977632805219003 0.9422868395490984 0.3460458041727052 1.0 0.8556519579770756 2 P23634 1 +Gamma aminobutyric acid signaling pathway 0.7977632805218994 0.9422868395490944 0.3460458041727072 1.0 0.8556519579770756 2 P55011 1 +Regulation of renal system process 0.7977632805218962 0.942286839549084 0.3460458041727126 1.0 0.8556519579770756 2 Q9Y5X3 1 +Renal sodium excretion 0.7977632805218962 0.942286839549084 0.3460458041727126 1.0 0.8556519579770756 2 Q9Y5X3 1 +Positive regulation of renal sodium excretion 0.7977632805218962 0.942286839549084 0.3460458041727126 1.0 0.8556519579770756 2 Q9Y5X3 1 +Renal tubular secretion 0.7977632805218962 0.942286839549084 0.3460458041727126 1.0 0.8556519579770756 2 Q9Y5X3 1 +Response to estrogen 0.4655046403489972 0.9416990227555684 0.3463467555240607 1.0 0.8556519579770756 12 P09601 1 +Regulation of cell activation 0.3218917551405623 0.9414751532649064 0.3464614163895831 1.0 0.8556519579770756 67 P10644,P49366,P11279,P09601,Q9BXW9,Q9NQT5,P04439,O00203,Q9HCL2,Q9NUQ9,O96028,P30825,O96005,Q9BWH2,Q08722,Q96FV9,Q12959 17 +B cell differentiation 0.455932118849417 0.9413390971416266 0.3465311130519806 1.0 0.8556519579770756 13 Q5HYI8,P04637,P55327 3 +Hormone catabolic process 0.7840273461777443 0.9413271044281608 0.3465372569162142 1.0 0.8556519579770756 3 P42892,Q8NBQ5 2 +Positive regulation of lipase activity 0.5332409518381754 0.9412202814060672 0.3465919853851982 1.0 0.8556519579770756 7 P35232,Q9Y263,Q99623 3 +Positive regulation of phospholipase activity 0.5332409518381754 0.9412202814060672 0.3465919853851982 1.0 0.8556519579770756 7 P35232,Q9Y263,Q99623 3 +Notch signaling pathway 0.397405726677784 0.9410069602237888 0.3467012923539847 1.0 0.8556519579770756 23 Q9UBV2,Q92542,P57105 3 +Toll like receptor 3 signaling pathway 0.6621486759881505 0.9398374468601364 0.3473009474758566 1.0 0.8561586188153876 4 Q5KU26,O75955 2 +Positive regulation of nitric oxide synthase activity 0.7965206585896123 0.9374218989671028 0.3485415807065555 1.0 0.8581600664612342 2 Q8WTV0 1 +Regulation of neurotransmitter levels 0.3938809071642307 0.9367754578534644 0.3488740720376628 1.0 0.8581600664612342 30 P50897,Q7L0J3,Q8NCG7,O75955,P21964,P16615 6 +Negative regulation of fatty acid transport 0.7962100031065558 0.9362064090052616 0.3491669240169308 1.0 0.8581600664612342 2 P31751 1 +Negative regulation of apoptotic signaling pathway 0.3261645360125431 0.9357004023577736 0.3494274634081769 1.0 0.8584764500858001 63 Q9P0J0,O60313,P02545,P09601,Q9NWS0,Q9H3K2,P61289,P05141,Q9NX61,P04899,P45880,Q15233,P38398,Q07820,O76024 15 +Regulation of glial cell proliferation 0.5762470051853052 0.935065171654316 0.3497547140649 1.0 0.858956430129975 5 Q96G23 1 +Negative regulation of autophagy of mitochondrion 0.7821753221046142 0.934392878255748 0.3501012700297066 1.0 0.8592980863510002 3 P04637 1 +Negative regulation of fatty acid biosynthetic process 0.6607537504424515 0.9341360605270288 0.3502337127436215 1.0 0.8592980863510002 4 P38398,O94905 2 +Negative regulation of blood circulation 0.7818757449802032 0.9332719350071452 0.3506795817055606 1.0 0.8599307664338539 3 P16615 1 +Protein import into peroxisome membrane 0.7949673811742656 0.9313474603750732 0.3516738590954844 1.0 0.860632410308672 2 P40855 1 +Regulation of monocyte chemotaxis 0.5506591381251728 0.931309542150914 0.3516934674181864 1.0 0.860632410308672 6 Q8NHP6,Q4KMQ2,Q99538 3 +Carbohydrate derivative catabolic process 0.3924242842029362 0.9308160410382272 0.3519487305234583 1.0 0.860632410308672 31 P16278,P17900,P54802,P04062,P16260,Q13126,Q9NUJ1 7 +Negative regulation of oxidoreductase activity 0.6597741048265858 0.9301342317476192 0.3523015888521523 1.0 0.860632410308672 4 P06280,Q15070 2 +Vesicle targeting to from or within golgi 0.4537889870015673 0.9277629793320614 0.3535305314465913 1.0 0.8618316128527497 13 P49755,Q9BVK6,Q9NR31,Q15363 4 +Mitochondrial protein catabolic process 0.7934141037589209 0.9252806265337602 0.3548199535095615 1.0 0.8618316128527497 2 Q9UG56 1 +Regulation of generation of precursor metabolites and energy 0.3843077782154074 0.9252616787401152 0.3548298070693407 1.0 0.8618316128527497 38 Q9BSK2,P14406,O14548,Q99623,Q9H3K2,P05067,Q04656 7 +Mitotic dna replication 0.4812683282172363 0.9230799515310238 0.3559655416298704 1.0 0.8637867260191303 10 O75844,P33991 2 +Sequestering of calcium ion 0.4325704638682532 0.9189119592518706 0.3581416240705453 1.0 0.8658482717932562 15 P35670 1 +Glial cell migration 0.4523857067008078 0.91887476698066 0.3581610795182306 1.0 0.8658482717932562 13 Q9NQC3,Q96G23,P30536 3 +Regulation of amino acid transmembrane transport 0.7779739343268629 0.9186909322665572 0.3582572540659301 1.0 0.8658482717932562 3 Q15041 1 +L glutamate import across plasma membrane 0.7779739343268629 0.9186909322665572 0.3582572540659301 1.0 0.8658482717932562 3 Q15041 1 +Regulation of l glutamate import across plasma membrane 0.7779739343268629 0.9186909322665572 0.3582572540659301 1.0 0.8658482717932562 3 Q15041 1 +Regulation of membrane repolarization 0.547549452754938 0.9162398739835056 0.3595410960191931 1.0 0.867614360271584 6 O75844 1 +Negative regulation of blood pressure 0.6562153014446457 0.9156124879362326 0.359870179123904 1.0 0.8677654485871852 4 Q9HB40,Q9Y5X3 2 +Protein hydroxylation 0.4279117276343849 0.914355676527852 0.3605299838129219 1.0 0.8688359490410242 16 Q96HE7,Q12797,Q96AY3,P13674,Q92791,P07237,O15460,Q9H267,Q32P28 9 +Xenobiotic metabolic process 0.4704466432582841 0.9136740334852016 0.3608881521852245 1.0 0.8692073557955758 11 P16435,P07099,Q6PIU2,Q08257,O43169 5 +Regulation of pattern recognition receptor signaling pathway 0.404681480413913 0.9134574920880748 0.3610019802590254 1.0 0.8692073557955758 21 Q9NQC3,Q9UBC1,Q86UT6,Q9NPR9,O75955,Q9NUD5,O43657,Q14254 8 +Feeding behavior 0.5274263162346395 0.9116596083099594 0.3619479330315476 1.0 0.8701009640778514 7 P05067,Q9GZP9 2 +Negative regulation of cholesterol metabolic process 0.7896862379620966 0.9107520252210396 0.3624260453789414 1.0 0.8702357948058074 2 O94905 1 +Negative regulation of alcohol biosynthetic process 0.7896862379620966 0.9107520252210396 0.3624260453789414 1.0 0.8702357948058074 2 O94905 1 +Pigment biosynthetic process 0.392846283478467 0.910415965262295 0.362603181172388 1.0 0.8702357948058074 26 P22830,Q9NP58,Q7KZN9,O00264,Q9P0S9,Q04656 6 +Regulation of electron transfer activity 0.7757408690835543 0.9103619610225262 0.3626316516356458 1.0 0.8702357948058074 3 Q99623 1 +Skin development 0.3825683935416691 0.9096334000390596 0.363015878083758 1.0 0.8705163527096893 38 O75844,Q16739,Q15392,Q9NP58,P04062,Q13510,Q04656 7 +Cardiocyte differentiation 0.41854304798964 0.9089004365460852 0.3634026833486246 1.0 0.8705879744638013 18 O75844 1 +Eye photoreceptor cell development 0.7753262896208697 0.9088169591611588 0.3634467530426954 1.0 0.8705879744638013 3 Q8NBN7,P54802 2 +Oocyte differentiation 0.4690762568130335 0.9055116526877358 0.3651943894087606 1.0 0.8718882178223086 11 Q15645,Q12768,Q8N2A8 3 +Camera type eye morphogenesis 0.5063114253991491 0.9029405335451928 0.3665574566047018 1.0 0.8725608922971555 8 Q16706,O95140,Q8NBN7,P54802,Q15555 5 +Viral protein processing 0.5056974906049627 0.8996651866639163 0.3682984553186221 1.0 0.8725608922971555 8 P27824,Q10472 2 +Response to misfolded protein 0.4859366872529931 0.8991191913328358 0.3685891768623761 1.0 0.8725608922971555 9 P46379,Q9BUN8 2 +Negative regulation of interleukin 6 production 0.7721765242941045 0.8970925481210863 0.3696695347587058 1.0 0.8725608922971555 3 P04062 1 +Neutrophil migration 0.4251968801169942 0.895662370837932 0.3704331133427967 1.0 0.8725608922971555 16 P84095,Q8NE86,Q8NHP6,P35613,Q8N5M9 5 +Immune response regulating signaling pathway 0.341375458674869 0.8954054959713708 0.3705703637709161 1.0 0.8725686114388925 57 Q13144,P46379,Q99623,Q9NQC3,Q5KU26,P51812,Q86UT6,O75955,Q9NUD5,Q08722,O43657,P35232,O00203 13 +Golgi vesicle transport 0.3803375432532367 0.8942619179386803 0.3711817703721412 1.0 0.873061347213346 130 Q4J6C6,Q9Y6Y8,O15498,Q15363,Q96PC5,Q9NR31,Q9Y296,Q9P2W9,Q8N2H4,O15127,Q9Y3B3,Q96RL7,P61026,O95070,P98194,P24390,Q8TBA6,Q9HCU5,O95249,Q12981,Q99747,O60749,Q9Y282,Q8NHH9,P62820,P11279,O60499,Q5JRA6,Q8TD16,Q9BVK6,Q567U6,P49755,P51572,O75396,Q9BZG1,Q969X5,O15258,O14828 38 +Regulation of cardiac muscle adaptation 0.7712341956221731 0.8935897067679356 0.3715414556776943 1.0 0.8732766152395609 3 P02545 1 +Embryonic pattern specification 0.5040818822163278 0.8910484504973797 0.3729031782246328 1.0 0.874016460095225 8 Q15363 1 +Steroid catabolic process 0.6501801525465098 0.8910463679290059 0.3729042954271762 1.0 0.874016460095225 4 Q8WTV0 1 +Insulin metabolic process 0.7837837837837842 0.8878439402506199 0.3746247032838696 1.0 0.8760971965845038 2 Q96HE7 1 +Regulation of leukocyte migration 0.3885422924487666 0.8866720626483596 0.3752554836847608 1.0 0.8763518594309135 29 Q8NE86,P84095,P09601,Q5JRA6,P14174,Q8NHP6,Q00013,P05067,Q4KMQ2,Q08722 10 +Regulation of phospholipase a2 activity 0.6489840375149436 0.8861871303896878 0.3755166974611783 1.0 0.8763518594309135 4 P50897 1 +Ribonucleoside triphosphate biosynthetic process 0.3888871909653409 0.8850169123604865 0.3761475098691376 1.0 0.8763518594309135 28 P06576,Q9UJS0,P56385,P24539,P00403,O75964 6 +Regulation of humoral immune response 0.7686253061629278 0.8839037314607137 0.3767481827393133 1.0 0.8763518594309135 3 Q99623 1 +Complement activation 0.7686253061629278 0.8839037314607137 0.3767481827393133 1.0 0.8763518594309135 3 Q99623 1 +Regulation of complement activation 0.7686253061629278 0.8839037314607137 0.3767481827393133 1.0 0.8763518594309135 3 Q99623 1 +Negative regulation of extrinsic apoptotic signaling pathway 0.3902185286177876 0.8835989812439139 0.3769127291885197 1.0 0.8763518594309135 23 P61289,P02545,P09601 3 +Keratan sulfate metabolic process 0.7678682411435687 0.8810962999044571 0.3782656997663096 1.0 0.8763518594309135 3 P16278,O43505 2 +Nucleoside triphosphate biosynthetic process 0.3838696222417841 0.880247284050002 0.3787253634494296 1.0 0.8763518594309135 34 P06576,Q9UJS0,P56385,P24539,P00403,Q9UIJ7,O75964 7 +Regulation of long chain fatty acid import across plasma membrane 0.7816091954022986 0.8794348762449687 0.3791655290033362 1.0 0.8763518594309135 2 P31751 1 +Long chain fatty acid import across plasma membrane 0.7816091954022986 0.8794348762449687 0.3791655290033362 1.0 0.8763518594309135 2 P31751 1 +Negative regulation of dna replication 0.5018719464577469 0.8792682518525987 0.3792558455958486 1.0 0.8763518594309135 8 P49916,P04637 2 +Protein o linked glycosylation via threonine 0.767291818436608 0.8789597593539326 0.3794230948863029 1.0 0.8763518594309135 3 Q10472 1 +Regulation of tetrapyrrole metabolic process 0.7672467371037854 0.878792700195465 0.379513684985389 1.0 0.8763518594309135 3 Q9NRK6,Q9P0S9 2 +Positive regulation of fatty acid metabolic process 0.6471308833793461 0.8786652074845669 0.3795828285889966 1.0 0.8763518594309135 4 Q92604,P50416 2 +Dna methylation involved in gamete generation 0.76708108819062 0.8781788967740775 0.3798466424377005 1.0 0.8763518594309135 3 Q8N2A8 1 +Regulation of animal organ morphogenesis 0.4821061940293567 0.8776194654506839 0.3801502621379025 1.0 0.8763518594309135 9 Q99623 1 +Negative regulation of dna binding transcription factor activity 0.3890866508623075 0.8773423202640069 0.3803007321480871 1.0 0.8763518594309135 25 Q99623,P09601,O76024 3 +Phosphatidylcholine metabolic process 0.44573346887007 0.8767597815592997 0.3806171282767441 1.0 0.8765768587222186 13 Q8NF37,P35790,Q8WTV0 3 +G protein coupled receptor signaling pathway involved in heart process 0.6459021225405857 0.8736821720193085 0.3822913624457191 1.0 0.8790690371124614 4 P23634 1 +Regulation of anion transport 0.4544118714415836 0.873581404995888 0.3823462564181015 1.0 0.8790690371124614 12 Q15041,O75915,Q7L0J3 3 +Phosphatidylinositol acyl chain remodeling 0.764139216904895 0.8672902424598241 0.3857830016247332 1.0 0.8796269411639122 3 Q92604,Q96N66 2 +Positive regulation of er associated ubiquitin dependent protein catabolic process 0.7781919850885254 0.8662554327610534 0.3863501006198901 1.0 0.8796269411639122 2 P51572 1 +Regulation of protein secretion 0.373404987687725 0.8652504861598787 0.3869013207443661 1.0 0.8796269411639122 41 Q8NE86,Q96KC8,P49755,P53985,Q9BRT2,Q6ZWJ1,P04035,P55011,P50416,Q5T9L3,Q16850,P40939,Q16836,Q8N5M9 14 +Cotranslational protein targeting to membrane 0.4524977881498192 0.8618401947270723 0.3887754628263544 1.0 0.8796269411639122 12 P43307 1 +Antigen processing and presentation via mhc class ib 0.762060461323812 0.8596105235344377 0.3900037720994858 1.0 0.8796269411639122 3 O00203 1 +Hindbrain morphogenesis 0.4788244882007635 0.8592170747880268 0.3902207647350353 1.0 0.8796269411639122 9 P04062 1 +Spontaneous synaptic transmission 0.7613384322757959 0.8569459045871519 0.3914747815796988 1.0 0.8796269411639122 3 P05067 1 +Regulation of spontaneous synaptic transmission 0.7613384322757959 0.8569459045871519 0.3914747815796988 1.0 0.8796269411639122 3 P05067 1 +Regulation of epithelial cell apoptotic process 0.4783737003805275 0.8566906265771673 0.3916158849949491 1.0 0.8796269411639122 9 P09601 1 +Neuron projection guidance 0.3857351031565523 0.8553107461354956 0.3923791399903937 1.0 0.8796269411639122 27 P84095,P42892,P35613,P05067,Q96TA1,O00264,Q15375,O75962 8 +Cellular response to external stimulus 0.3655551532614129 0.8547508260546799 0.3926891063834086 1.0 0.8796269411639122 45 P09601,Q9Y371,Q9Y4P3,P04062,P13473,P21964 6 +Camera type eye photoreceptor cell differentiation 0.7750854302578303 0.8543121268628413 0.3929320697285832 1.0 0.8796269411639122 2 P54802 1 +Retinal rod cell differentiation 0.7750854302578303 0.8543121268628413 0.3929320697285832 1.0 0.8796269411639122 2 P54802 1 +Retinal rod cell development 0.7750854302578303 0.8543121268628413 0.3929320697285832 1.0 0.8796269411639122 2 P54802 1 +Regulation of cellular response to osmotic stress 0.7605236118293202 0.8539406203218672 0.393137891207465 1.0 0.8796269411639122 3 O95202 1 +Regulation of t cell mediated immunity 0.4959922508822709 0.847966455648695 0.3964566523371493 1.0 0.8816677624073073 8 P04439,O15400 2 +Ketone biosynthetic process 0.5325759853979186 0.8439069306566093 0.3987214150194309 1.0 0.8816677624073073 6 Q86YH6,O75208,P22570 3 +Inositol phosphate catabolic process 0.5561502648207651 0.8438481687538137 0.398754254705369 1.0 0.8816677624073073 5 Q9NX62 1 +Regulation of cellular carbohydrate catabolic process 0.5325088375018606 0.8435835621592477 0.3989021529631367 1.0 0.8816677624073073 6 Q14108 1 +Cell adhesion molecule production 0.7576616626872481 0.8434001351805774 0.3990046963555342 1.0 0.8816677624073073 3 Q5KU26 1 +Positive regulation of cell adhesion molecule production 0.7576616626872481 0.8434001351805774 0.3990046963555342 1.0 0.8816677624073073 3 Q5KU26 1 +Body morphogenesis 0.4757204637486812 0.8418278527118744 0.3998843190774122 1.0 0.8816677624073073 9 O95470 1 +Cell motility involved in cerebral cortex radial glia guided migration 0.7716682199440802 0.8412177002558517 0.4002259862914634 1.0 0.8821224530342814 2 Q8WXH0 1 +Localization within membrane 0.4161994027984352 0.8399521813288419 0.4009351983963745 1.0 0.8823416980772004 180 Q9P0J0,Q15363,P46379,O43681,Q9NS69,Q8N2H4,P40855,O60725,P98194,P07602,Q9Y5J9,Q14168,P43307,Q9Y512,Q9NPA0,P27105,Q9BTX1,O14737,P57105,Q9Y5J6,O15118,Q8N8Q8,O15400,Q9Y371,P49354,Q15070,Q9HD45,Q15041,Q96L92,Q567U6,Q13641,Q15904,Q9HD20,Q9NZJ7,Q96A33,Q53H12,O00264,O75955,O15258,P35613,O00203 41 +Positive regulation of interleukin 1 production 0.4944621884909184 0.8398315711751987 0.4010028291583776 1.0 0.8823416980772004 8 P49755,P05067 2 +Hindbrain development 0.3770026089550162 0.8383520691661154 0.4018330003286843 1.0 0.8826262873513161 36 O14949,P04637,Q92542,P54802,Q5KU26,P04062,Q04656 7 +Regulation of glucocorticoid metabolic process 0.7701149425287247 0.8352810536259192 0.4035594823986579 1.0 0.8826262873513161 2 P05023 1 +Intracellular distribution of mitochondria 0.7553154405555444 0.8347770737768924 0.4038432365391469 1.0 0.8826262873513161 3 O75153 1 +Microtubule anchoring at centrosome 0.554072053817114 0.8344640611665529 0.4040195311249235 1.0 0.8826262873513161 5 Q15154,Q9Y496 2 +Cytosolic transport 0.3132030156892426 0.8335174514060102 0.4045529597490194 1.0 0.8826262873513161 67 Q9BVK6,P11279,O60499,Q8NBN3,Q96ED9,Q8N2H4,O75503,O95249,O60749,Q96RL7 10 +Estrogen biosynthetic process 0.7548703178383267 0.8331429850388374 0.4047640933284233 1.0 0.8826262873513161 3 Q53GQ0 1 +Regulation of mitochondrial fission 0.4477588602855594 0.8327944103370898 0.4049606877395335 1.0 0.8826262873513161 12 Q8NE86,Q969V5,Q9NUQ9,Q9NX47 4 +Negative regulation of endoplasmic reticulum unfolded protein response 0.5536542130046251 0.832578595498068 0.4050824348531225 1.0 0.8826262873513161 5 O76024 1 +Cerebellar purkinje cell layer morphogenesis 0.7543956007677322 0.8314009171012819 0.4057471811579656 1.0 0.8832324167385796 3 P04062 1 +Positive regulation of keratinocyte proliferation 0.7679403541472518 0.8269862597314979 0.4082448494543524 1.0 0.8843739217457599 2 Q6ZWJ1 1 +Atrial septum development 0.7679403541472405 0.8269862597314552 0.4082448494543766 1.0 0.8843739217457599 2 O96028 1 +Atrial septum morphogenesis 0.7679403541472405 0.8269862597314552 0.4082448494543766 1.0 0.8843739217457599 2 O96028 1 +Cardiac atrium morphogenesis 0.7679403541472405 0.8269862597314552 0.4082448494543766 1.0 0.8843739217457599 2 O96028 1 +Cardiac atrium development 0.7679403541472405 0.8269862597314552 0.4082448494543766 1.0 0.8843739217457599 2 O96028 1 +Vesicle docking 0.4025389430239997 0.8255510942755588 0.4090587873588409 1.0 0.8851162398897445 19 Q86Y82,P61026,O15498,O60499,O15400 5 +Response to interleukin 12 0.7673190431811003 0.8246199065434033 0.4095874161655861 1.0 0.8856715941190114 2 Q08722 1 +Oligodendrocyte development 0.4906246980198616 0.8194507418143276 0.4125292947853678 1.0 0.8887675575999029 8 Q92542 1 +Programmed necrotic cell death 0.4273849638069817 0.8192273715424548 0.41265670108738 1.0 0.8887675575999029 14 P04637,Q13510 2 +Receptor localization to synapse 0.4543680422882492 0.8180580199823999 0.4133240582300383 1.0 0.8899106086784264 11 Q14168,O15400,P57105 3 +Cardiolipin acyl chain remodeling 0.7639018328673357 0.8116340387278832 0.4170016535847831 1.0 0.8946953168766898 2 P40939 1 +Cellular response to sterol depletion 0.5487792348982655 0.8106140530783141 0.4175873440072837 1.0 0.8955371654657355 5 Q15363,O94905 2 +Establishment of protein localization to organelle 0.4157510569980424 0.8088427100732938 0.4186056257034538 1.0 0.8961669188110396 183 Q9P0J0,P52789,P46379,Q8N4H5,O43681,Q7Z4Q2,P30536,P55786,Q9NS69,Q9Y3D6,Q99797,O43615,P56589,Q10713,P40855,Q7Z3B4,Q6UWE0,Q99567,Q15005,Q96P70,Q96RL7,P61026,O60830,O14925,Q5JRX3,Q9Y5J9,Q9UGP8,Q9Y512,Q96ES7,O96008,O14737,Q7L5D6,Q9Y5J6,P02545,P52292,Q9H9H4,P11279,Q92973,Q99623,Q8N8Q8,Q8TB36,O95831,O43765,Q99442,Q9Y371,Q8TEX9,Q15070,Q15388,Q14108,Q8NFH5,Q9NWS0,O95140,O00165,P04637,P51572,Q53H12,P13473,Q3ZCQ8,Q9Y5M8,O75381,O00203 61 +Protein processing involved in protein targeting to mitochondrion 0.7481609571127501 0.8085869528298398 0.4187527720334696 1.0 0.8961669188110396 3 Q99797 1 +Purine nucleoside metabolic process 0.4527042544578439 0.8081890332604719 0.418981769964627 1.0 0.8961669188110396 11 O60725,P16260 2 +Membrane invagination 0.4608483221083253 0.8052446843273973 0.420678495424351 1.0 0.896646616703141 10 P51790,P84095,Q4KMQ2 3 +Positive regulation of establishment of protein localization to mitochondrion 0.4431948106698813 0.8048586638252785 0.4209012443021849 1.0 0.896646616703141 12 Q9Y371 1 +Myeloid leukocyte activation 0.3853543996238335 0.8035921135724606 0.4216325792304247 1.0 0.896646616703141 22 Q99584,P53634,P09601,Q04721,P05067,Q9UNH7,P51809 7 +Endothelial cell proliferation 0.3992897748368025 0.8018088649360243 0.4226635298827852 1.0 0.896646616703141 19 P57105,P09601 2 +Synaptic vesicle transport 0.4601066501448466 0.8009792420108491 0.4231436631537306 1.0 0.896646616703141 10 Q96A57,O00203 2 +Cerebral cortex cell migration 0.4601013217895655 0.8009486027598938 0.4231614013260003 1.0 0.896646616703141 10 Q9NQC3,Q8WXH0,Q96N66 3 +Positive regulation of autophagy of mitochondrion 0.5463780453922664 0.7998190199923118 0.42381566151627 1.0 0.896646616703141 5 P12235,P21796 2 +Fermentation 0.7457349789392518 0.7997436063456729 0.4238593625528142 1.0 0.896646616703141 3 P04637 1 +Glycolytic fermentation 0.7457349789392518 0.7997436063456729 0.4238593625528142 1.0 0.896646616703141 3 P04637 1 +Positive regulation of skeletal muscle tissue development 0.5462449589430451 0.7992211815517877 0.4241621719733421 1.0 0.896646616703141 5 O75955 1 +Positive regulation of muscle tissue development 0.5462449589430451 0.7992211815517877 0.4241621719733421 1.0 0.896646616703141 5 O75955 1 +Meiosis i cell cycle process 0.4031663252720804 0.7987877077416152 0.4244135193549603 1.0 0.8968868434649112 18 Q9BTX1,Q15645,Q92791,P46379 4 +Neuron cellular homeostasis 0.4864464943956074 0.7972996649035528 0.4252770149145313 1.0 0.8977580800200373 8 P20020,P51790 2 +Natural killer cell activation involved in immune response 0.7442659745716133 0.7943982323056413 0.4269636329450492 1.0 0.8987763869977717 3 P11279 1 +Natural killer cell degranulation 0.7442659745716133 0.7943982323056413 0.4269636329450492 1.0 0.8987763869977717 3 P11279 1 +Muscle hypertrophy 0.4101609472920913 0.7922567017582035 0.4282110126611487 1.0 0.8998864339634414 16 P02545 1 +Catechol containing compound metabolic process 0.5032131149972338 0.789200946862725 0.4299945686686843 1.0 0.8998864339634414 7 P21964 1 +Postsynaptic cytoskeleton organization 0.5432954907942764 0.7859851947269714 0.431876160876202 1.0 0.8999752188519218 5 P07196 1 +G1 to g0 transition 0.5025718744496528 0.7859764936781773 0.4318812584733082 1.0 0.8999752188519218 7 O43175 1 +Rho protein signal transduction 0.3775939446988787 0.7827268771841985 0.433787515566439 1.0 0.8999752188519218 23 P57105,Q9P035 2 +Phosphate ion transport 0.7408328154132702 0.7819345214970667 0.4342530557267805 1.0 0.8999752188519218 3 Q9UBX3,Q00325 2 +Phosphate ion transmembrane transport 0.7408328154132702 0.7819345214970667 0.4342530557267805 1.0 0.8999752188519218 3 Q9UBX3,Q00325 2 +Dopamine metabolic process 0.5196254564155267 0.7817477866477172 0.4343628118172487 1.0 0.8999752188519218 6 P21964 1 +Positive regulation of nik nf kappab signaling 0.4563561194818231 0.7794304573301526 0.4357261881729302 1.0 0.8999752188519218 10 P05067,Q99623 2 +Negative regulation of transport 0.3204527754478741 0.7781649868788706 0.4364717551003558 1.0 0.8999752188519218 78 Q96PU5,Q16836,P09601,Q08722,P05067,P21796,P04035,Q16850,P40939,Q9GZP9,Q8N5M9 11 +Coenzyme a biosynthetic process 0.5009294387522248 0.7777229837101536 0.4367323396233691 1.0 0.8999752188519218 7 P16260 1 +Chondroitin sulfate biosynthetic process 0.7396138281702476 0.7775190182272381 0.4368526184032681 1.0 0.8999752188519218 3 Q8N6G5 1 +Chondroitin sulfate proteoglycan biosynthetic process 0.7396138281702476 0.7775190182272381 0.4368526184032681 1.0 0.8999752188519218 3 Q8N6G5 1 +Negative regulation of response to wounding 0.5005944943207181 0.7760408079938625 0.4377248913853189 1.0 0.8999752188519218 7 Q96G23 1 +Positive regulation of triglyceride metabolic process 0.7384803802978155 0.7734181053921446 0.4392749782649341 1.0 0.9002704607328272 3 Q8WTV0 1 +Regulation of histamine secretion by mast cell 0.7536502019260608 0.7729852683798853 0.4395310991299292 1.0 0.9002704607328272 2 Q9UNH7 1 +Positive regulation of leukocyte cell cell adhesion 0.3762613156675446 0.772447870012255 0.4398492109171019 1.0 0.9002704607328272 24 O00203,P04439,Q9HCL2,P30825,Q08722,Q9NUQ9 6 +Intermediate filament bundle assembly 0.7378947656501289 0.771301109129469 0.4405284751044864 1.0 0.9002704607328272 3 P07197 1 +Positive regulation of secondary metabolite biosynthetic process 0.7524075799937759 0.7683335242096359 0.4422890626940972 1.0 0.9017235909475724 2 Q04656 1 +Regulation of fc gamma receptor signaling pathway involved in phagocytosis 0.752407579993774 0.7683335242096287 0.4422890626941014 1.0 0.9017235909475724 2 Q08722 1 +Sprouting angiogenesis 0.4062947878180944 0.7657307646690518 0.4438365176535639 1.0 0.9036087111421542 16 Q5JRA6,P57105,P09601 3 +Cellular response to calcium ion 0.4275098091813233 0.761720694373654 0.4462267214776751 1.0 0.9036087111421542 13 Q92542 1 +Cellular response to antibiotic 0.6180136946004335 0.7617076177303944 0.4462345277854904 1.0 0.9036087111421542 4 Q04656 1 +Positive regulation of hydrolase activity 0.3323927592196635 0.7611343943888242 0.4465767988755287 1.0 0.9036087111421542 91 Q9P0J0,P61289,Q92542,P07602,Q9UL46,P05067,Q96A26,O14737,P84095,O95831,Q99623,P49354,Q969V5,Q8IZ81,P50148,Q96HY6,Q9Y263,P51572,Q9NZJ7,P31751,O75915,P35232 22 +Camera type eye development 0.3717060266681354 0.760979712665426 0.44666918477242 1.0 0.9036087111421542 32 Q16706,Q8NF37,O95140,Q8NBN7,Q99471,P54802,Q99797,P20020,P08670,Q6KCM7,Q12959 11 +Telencephalon glial cell migration 0.4794922576711109 0.7605355352106303 0.4469345366322583 1.0 0.9036087111421542 8 Q9NQC3,Q8WXH0,Q96N66 3 +Cerebral cortex radially oriented cell migration 0.4794922576711109 0.7605355352106303 0.4469345366322583 1.0 0.9036087111421542 8 Q9NQC3,Q8WXH0,Q96N66 3 +Negative regulation of reactive oxygen species metabolic process 0.4529418107948088 0.7598466125418288 0.4473462767764817 1.0 0.9036087111421542 10 P38398,P11413,P04637,P52789 4 +Positive regulation of t cell mediated immunity 0.4972004773218846 0.7590145956322117 0.4478438257438413 1.0 0.9036087111421542 7 P04439,O15400 2 +Regulation of glucose transmembrane transport 0.4270580245808704 0.7588782878349579 0.4479253682424731 1.0 0.9036087111421542 13 P52789,Q6ZWJ1,P31751,O75298,Q9UKG1 5 +Positive regulation of fatty acid transport 0.7496116806461628 0.7578942953003455 0.4485142656907122 1.0 0.9036087111421542 2 P33121 1 +Macropinocytosis 0.7327532628962109 0.7527686798967576 0.451588930670654 1.0 0.9057567714425334 3 Q9BZG1,Q9UKG1 2 +Cytoplasm organization 0.7324425108763001 0.7516517555070259 0.4522605103215305 1.0 0.9057567714425334 3 Q9Y2W6,Q8N2A8 2 +Axonal transport of mitochondrion 0.6152698443232851 0.7508251519166905 0.4527578902975953 1.0 0.9057567714425334 4 O60313 1 +Photoreceptor cell differentiation 0.535121621412736 0.7494468350202474 0.4535879312185398 1.0 0.9057646593169464 5 P54802 1 +Detection of external biotic stimulus 0.7315266069308446 0.7483619043164766 0.4542418944604229 1.0 0.9058258117290598 3 Q8WTV0 1 +Cilium movement 0.4771820643564919 0.7483548667629192 0.4542461382180709 1.0 0.9058258117290598 8 Q9GZT3,P23634,Q96RL7 3 +Mononuclear cell migration 0.3729764691623967 0.7468715823928967 0.4551410811178524 1.0 0.9058258117290598 25 Q5JRA6,P04062,P05067,P55011,Q4KMQ2,Q08722 6 +Epithelial cell proliferation 0.3523129219073802 0.7441174746332946 0.456805408369757 1.0 0.9070651294854352 46 P09601,Q92542,Q9NQC3,P57105,Q8WTV0 5 +Suckling behavior 0.7299545063114887 0.7427225947961013 0.4576496472511842 1.0 0.9071678011533874 3 Q9GZP9 1 +Male meiotic nuclear division 0.53358409856373 0.7425990478524392 0.4577244651611056 1.0 0.9071678011533874 5 Q15645 1 +Myelin assembly 0.4935507579782899 0.7407472301675855 0.4588467164527026 1.0 0.9071678011533874 7 Q16880,Q9NR77 2 +Adenylate cyclase modulating g protein coupled receptor signaling pathway 0.4321966003385577 0.7377472581440679 0.4606680486255281 1.0 0.9086349711904992 12 P50148,P07602,P04899,P23634,Q9NZJ7 5 +Regulation of muscle adaptation 0.414491951648568 0.7353609390408502 0.4621197041167992 1.0 0.9093007954419076 14 P02545 1 +Positive regulation of neural precursor cell proliferation 0.5093849279795031 0.7329449007419508 0.4635920359314633 1.0 0.9099984719775832 6 P04899,P55209 2 +Cellular response to vitamin d 0.7259835521339641 0.7285216581999354 0.4662943156001378 1.0 0.9131012860804864 3 Q8TB36 1 +Organelle transport along microtubule 0.3698374674885617 0.7273686282247824 0.4670001672396053 1.0 0.9133564959493458 28 O60313,Q8IXI1,P11279,P62820,P07196,Q8TD16,O75381,Q5SNT2,O00203 9 +Negative regulation of transforming growth factor beta receptor signaling pathway 0.4726207241925579 0.7243577950817204 0.4688461034867521 1.0 0.9133564959493458 8 Q9UNH7,Q92896,P04637,Q9UNE7 4 +Myeloid leukocyte migration 0.3691260817452712 0.7214901668975933 0.4706079884082086 1.0 0.9133564959493458 28 Q8NE86,P84095,Q00013,P14174,Q8NHP6,Q9BW27,P78310,Q4KMQ2,Q08722,P35613,Q8N5M9 11 +Intermediate filament based process 0.4209625528695605 0.7205907732321959 0.4711613323600687 1.0 0.9133564959493458 13 P08670,P07197,Q16352,P07196 4 +Tripartite regional subdivision 0.6070936530287507 0.7185652279550527 0.4724088444655967 1.0 0.9133564959493458 4 Q8N2A8 1 +Cell fate determination 0.6063075508286986 0.7154774786287935 0.4743140522883458 1.0 0.9133564959493458 4 Q07820 1 +Lysosomal membrane organization 0.7381174277726009 0.7153917052156346 0.4743670365229009 1.0 0.9133564959493458 2 Q9Y3E7 1 +Response to nutrient 0.369046789497138 0.7150970107679924 0.474549100918892 1.0 0.9133564959493458 25 P16435,P33121,P09601,Q8TB36,P35573,P04899,P30536,P20020,O15228 9 +Ubiquitin recycling 0.6060788874958795 0.7145797809070493 0.4748687420997475 1.0 0.9133564959493458 4 Q9Y263 1 +Response to sterol depletion 0.5052396298490823 0.7132943767241786 0.4756636164279442 1.0 0.9133564959493458 6 Q15363,O94905 2 +Embryonic heart tube morphogenesis 0.7215661901802046 0.7127995525518896 0.475969802546436 1.0 0.9133564959493458 3 Q04721,Q15363 2 +Phosphatidylcholine biosynthetic process 0.5050401965700182 0.7123506349044153 0.4762476761838958 1.0 0.9133564959493458 6 P35790 1 +Cytoplasmic pattern recognition receptor signaling pathway 0.4017744602730009 0.7115178980189573 0.4767633637869488 1.0 0.9133564959493458 15 Q9NUD5,Q86UT6,O43657,Q99623 4 +Regulation of lymphocyte migration 0.5046154889885575 0.7103413904883159 0.4774924585750044 1.0 0.9133564959493458 6 P05067 1 +Positive regulation of g protein coupled receptor signaling pathway 0.7205819101166477 0.7093074579785947 0.4781337012994404 1.0 0.9133564959493458 3 Q15043 1 +Double strand break repair via break induced replication 0.4696725973436339 0.7088880944846839 0.4783939237610239 1.0 0.9133564959493458 8 P33991,Q9BRT9,Q14566,Q9Y248 4 +Negative regulation of response to external stimulus 0.3340329502731123 0.7044796315931617 0.4811341302510135 1.0 0.9133564959493458 53 P04062,Q14166,Q96G23,Q969V5,P80303,O43657 6 +Sulfur compound biosynthetic process 0.3515886655865069 0.7044715422022804 0.4811391662864688 1.0 0.9133564959493458 44 P50897,Q8N6G5,Q8TB61,Q8NCH0,Q53GQ0,Q9UJ14,P09622,O43252,Q9UKU0,Q13126,Q9NZ01,Q99735 12 +Negative regulation of cellular response to growth factor stimulus 0.443206670947391 0.7042134887074781 0.4812998320756825 1.0 0.9133564959493458 10 P18031,O94813,P23634,O14964,Q96TA1,O75340 6 +Vascular associated smooth muscle cell proliferation 0.468406215181161 0.7022533721298376 0.482521166299767 1.0 0.9133564959493458 8 O95140,P09601 2 +Retina homeostasis 0.7178371659415603 0.6995914105880559 0.4841825082350772 1.0 0.9133564959493458 3 Q15555,P51790 2 +Photoreceptor cell maintenance 0.7178371659415603 0.6995914105880559 0.4841825082350772 1.0 0.9133564959493458 3 Q15555,P51790 2 +Leukocyte proliferation 0.3591866890036519 0.6994175594383073 0.4842911172979971 1.0 0.9133564959493458 38 P10644,P04439,P04637,Q9HCL2,Q92542,P30825,P04062,Q12959 8 +Purine containing compound biosynthetic process 0.3119040538523863 0.6984645810992419 0.4848867007354998 1.0 0.9133564959493458 76 Q8WVC6,P06576,P50897,Q9UJS0,P56385,P24539,Q8TB61,Q53GQ0,P00403,P09622,O43252,Q9UIJ7,Q9UKU0,O75964,Q13126,P16260,Q9NZ01 17 +Cytoplasmic pattern recognition receptor signaling pathway in response to virus 0.4254800805648277 0.6969505167947482 0.4858337618185548 1.0 0.9133564959493458 12 Q9NUD5,Q86UT6,O43657,Q99623 4 +Regulation of lymphocyte apoptotic process 0.467097389607131 0.6954030912405755 0.4868027238432835 1.0 0.9133564959493458 8 Q9HCL2 1 +Antigen processing and presentation of peptide or polysaccharide antigen via mhc class ii 0.7325256290773545 0.694969917930594 0.4870741538780032 1.0 0.9133564959493458 2 Q99538 1 +Antigen processing and presentation of exogenous peptide antigen via mhc class ii 0.7325256290773545 0.694969917930594 0.4870741538780032 1.0 0.9133564959493458 2 Q99538 1 +Regulation of calcium ion dependent exocytosis 0.5227757840114612 0.6947125894828666 0.487235436741197 1.0 0.9133564959493458 5 P16615 1 +Negative regulation of response to biotic stimulus 0.3665394752708595 0.6943867051793345 0.4874397289693994 1.0 0.9133564959493458 24 Q969V5,Q14166,O43657 3 +Plus end directed organelle transport along microtubule 0.7322149735942834 0.6938405145824036 0.4877822317522096 1.0 0.9133564959493458 2 Q9Y496 1 +Regulation of glucose import 0.4411923637362078 0.6927461014480496 0.4884689021207531 1.0 0.9133564959493458 10 O75298,P31751,P52789,Q9UKG1 4 +Positive regulation of endoplasmic reticulum unfolded protein response 0.7319043181112006 0.6927116616521702 0.4884905192224869 1.0 0.9133564959493458 2 P57088 1 +Positive regulation of ire1 mediated unfolded protein response 0.7319043181112006 0.6927116616521702 0.4884905192224869 1.0 0.9133564959493458 2 P57088 1 +Regulation of perk mediated unfolded protein response 0.7319043181112006 0.6927116616521702 0.4884905192224869 1.0 0.9133564959493458 2 P57088 1 +Regulation of phospholipid metabolic process 0.4411771850655563 0.6926597526262945 0.4885231023497862 1.0 0.9133564959493458 10 Q99623,Q8WTV0 2 +Neuron remodeling 0.7315936626281324 0.6915833605476076 0.4891990141249447 1.0 0.9133564959493458 2 P05067 1 +Cardiac muscle cell membrane repolarization 0.4830822001620759 0.6886207944182605 0.4910619316962441 1.0 0.9133564959493458 7 O75844 1 +Vesicle targeting rough er to cis golgi 0.4321554899338242 0.6869428651396454 0.492118733439485 1.0 0.9133564959493458 11 P49755,Q9NR31,Q15363 3 +Regulation of erbb signaling pathway 0.4321102259739968 0.6866774358580012 0.4922860191179539 1.0 0.9133564959493458 11 Q9NQC3,Q9Y5X3 2 +Golgi to plasma membrane protein transport 0.3979005372631558 0.6856078163632574 0.4929604512306649 1.0 0.9133564959493458 15 P61026,Q9BZG1,P98194,Q8N2H4 4 +Dna replication independent chromatin organization 0.465220533024509 0.6855922444012863 0.4929702735466095 1.0 0.9133564959493458 8 Q6IPU0 1 +Negative regulation of cytokine production 0.3647368670504256 0.6852500794163604 0.49318612718824 1.0 0.9133564959493458 28 P04062,Q86UT6,Q969V5,P09601 4 +Eye photoreceptor cell differentiation 0.598566751701368 0.6852111780689485 0.4932106711784891 1.0 0.9133564959493458 4 P54802 1 +Lymphocyte apoptotic process 0.3943179484976263 0.6838380291242628 0.4940774497259403 1.0 0.9133564959493458 16 P24390,Q9HCL2 2 +Axoneme assembly 0.7125543816034757 0.6809844263336874 0.4958813448002988 1.0 0.9133564959493458 3 A0AVF1,Q15555 2 +Branched chain amino acid transport 0.7284871077974393 0.6803310107873146 0.4962948931620965 1.0 0.9133564959493458 2 Q96H78 1 +Nucleoside triphosphate metabolic process 0.3455765833920378 0.6785848681730431 0.4974009332716393 1.0 0.9137365686869316 46 O60313,P06576,Q8IWA4,Q9UJS0,P24539,P00403,Q9UIJ7,O75964 8 +Entry into host 0.3619680593692015 0.6779589063650285 0.4977977488448677 1.0 0.9137365686869316 32 Q14108,P11279,O15118,Q8WTV0 4 +Isotype switching to iga isotypes 0.7116356883301017 0.6777614977002063 0.4979229269345115 1.0 0.9137365686869316 3 O96028 1 +Exocytosis 0.3087881314914104 0.672902650877445 0.5010092256230665 1.0 0.9158218036719148 75 Q4J6C6,O15498,Q9Y3E7,Q9UPT5,P04899,Q92905,P51809,P16615,P61026,Q99584,P09601,Q9BRK5,Q5JRA6,P11279,O43760,Q68EM7,Q9UNH7,Q92543,Q8N5M9,P49755,Q7L0J3,Q8TBQ9 22 +Neurotransmitter metabolic process 0.5949762759710923 0.6712622566968075 0.5020534743868241 1.0 0.9162621392470748 4 P21964 1 +Antigen processing and presentation of endogenous peptide antigen via mhc class i via er pathway 0.7097576134244725 0.6711850637814171 0.5021026425207611 1.0 0.9162621392470748 3 P04439,P10321 2 +Negative regulation of histone acetylation 0.4962740030960972 0.6710304588291564 0.5022011260187997 1.0 0.9162621392470748 6 P38398,Q01105 2 +Cytoskeleton dependent intracellular transport 0.3156123703147126 0.6683387489505289 0.5039173840898359 1.0 0.917191365639306 59 O60313,Q8IXI1,P11279,Q9UH99,P62820,P23246,P07196,Q14168,Q8TD16,Q96ED9,A0AVF1,P05067,O75381,Q5SNT2,O00203 15 +Protein localization to microtubule end 0.7247592420006196 0.6669032182584577 0.5048339551430552 1.0 0.9179183556244328 2 Q15555 1 +Nadph regeneration 0.4440719916265742 0.665994524670698 0.505414600128339 1.0 0.9187176362366376 9 Q13423,P04637 2 +Dendrite extension 0.4613746659046792 0.6655369784118483 0.5057071001136286 1.0 0.918956629176026 8 Q96PU5,Q969V5 2 +Negative regulation of peptidyl lysine acetylation 0.4607192814286839 0.6621260422554914 0.5078904471243852 1.0 0.9206566413794284 8 P38398,Q01105 2 +Regulation of neutrophil migration 0.4604874491093068 0.6609199597636685 0.5086636450380086 1.0 0.9206566413794284 8 Q8NHP6,P84095,Q8NE86 3 +Regulation of mitochondrial dna replication 0.7066500932255709 0.6603399976668481 0.5090356679360166 1.0 0.9206566413794284 3 P49916,Q9UJZ1 2 +Regulation of dna dependent dna replication 0.3714130372631602 0.6599149007599567 0.5093084414079656 1.0 0.9206566413794284 21 P49916,O75844 2 +Phosphatidylinositol dephosphorylation 0.4936682687355915 0.6588135098413508 0.5100155308538947 1.0 0.9206604272341532 6 Q9NTJ5,Q10713 2 +Regulation of entry of bacterium into host cell 0.7058190846019327 0.6574476671927699 0.5108931103188925 1.0 0.9206604272341532 3 Q9BTY2 1 +Negative regulation of map kinase activity 0.4597674825693229 0.657176042950663 0.5110677279916027 1.0 0.9206604272341532 8 P04062 1 +Anterograde axonal transport 0.4188845490313849 0.6570659186485528 0.5111385319141482 1.0 0.9206604272341532 12 P07196,Q14168,Q9Y496,P33176,O00203 5 +Regulation of response to biotic stimulus 0.3000485149405066 0.6563900325498977 0.5115732020296813 1.0 0.9206604272341532 68 O75844,P11279,P23246,Q9NZ08,P04439,Q9NUD5,Q8WXF1,Q15233,Q86UT6,Q14166,Q969V5,Q6UWE0,Q8IZ81,O43657 14 +Ceramide 1 phosphate transport 0.7210313762037873 0.653559619113609 0.5133955672647272 1.0 0.9228114883135082 2 Q9NZD2 1 +Regulation of dna damage response signal transduction by p53 class mediator 0.4417052147568546 0.6529952809129311 0.5137593208390574 1.0 0.9228114883135082 9 O75844 1 +Glycosyl compound metabolic process 0.3603502029046415 0.6518100722538954 0.514523703179181 1.0 0.923093523190004 29 Q13126,P04062,P16260,O60725 4 +Cellular response to carbohydrate stimulus 0.36101133299841 0.6502634042354681 0.5155220916033747 1.0 0.9237636675317203 25 Q5KU26,Q8N5M9 2 +Fatty acid alpha oxidation 0.70352358243048 0.6494756621334605 0.5160309725954582 1.0 0.9238734878639212 3 A1L0T0 1 +Negative regulation of natural killer cell mediated immunity 0.7028200591847762 0.6470376119058119 0.517607601247644 1.0 0.92461443908882 3 P04439 1 +Regulation of protein kinase a signaling 0.7191674433053741 0.646920176695171 0.5176836066624271 1.0 0.92461443908882 2 P14174 1 +Protein deglycosylation 0.49105785573223 0.6466070403953574 0.5178863002911125 1.0 0.92461443908882 6 Q16706,O60858 2 +Negative regulation of defense response 0.355985039417478 0.6452494452430583 0.5187655483804496 1.0 0.9248215898382568 35 Q969V5,P04062,Q14166,O43657 4 +Neuromuscular junction development 0.4246805611159752 0.643235320527604 0.5200714179310308 1.0 0.9248215898382568 11 P05067,P49354 2 +Forebrain cell migration 0.4246544513600794 0.6430831222994198 0.520170165378866 1.0 0.9248215898382568 11 Q9NQC3,Q8WXH0,Q96N66 3 +Organ growth 0.3647256713083009 0.6430251534166371 0.5202077786031407 1.0 0.9248215898382568 22 P16435,O75844,P07602,Q9NZJ7 4 +Purine containing compound transmembrane transport 0.4568954638963214 0.6422663539559474 0.5207002564005663 1.0 0.9248215898382568 8 P12236,P05141,Q8TB61,P12235,Q8TDW0 5 +Animal organ morphogenesis 0.3274808749725988 0.6406966296904434 0.5217198043187992 1.0 0.926379794309798 96 Q15363,Q9BXW9,Q9NX62,P54802,Q9NQC3,Q12959,O96028,Q13616,O95470,O75844,P16435,Q99623,P04062,Q6P4Q7,Q7Z3C6,Q16706,O95140,Q8NBN7,P04637,P04920,P10253,Q92896,P53701,P35613,O00203 25 +Sterol transport 0.3597821923278793 0.6402946577742631 0.5219810532035818 1.0 0.926591060102188 24 P61916,P30536,O15118,Q8WTV0 4 +Gland development 0.3059408258183241 0.6377157954093639 0.5236587015205667 1.0 0.9268111995812864 75 O75844,P07602,P09601,P52789,Q99623,Q13505,Q9NZJ7,P00403,Q9NQC3,P35670 10 +Vasoconstriction 0.5857550969511693 0.6357194840866931 0.5249592746176668 1.0 0.9268111995812864 4 P42892 1 +Carnitine metabolic process 0.4886556743380476 0.6354041213634141 0.5251648808243292 1.0 0.9268111995812864 6 P16435,Q9NVH6,P23786 3 +Nephron morphogenesis 0.5087064676616843 0.6331337464470348 0.5266463065585212 1.0 0.9268111995812864 5 P35222,Q12959,O95747,P42224 4 +Heart morphogenesis 0.3582722045956444 0.6319942359644177 0.5273906436866242 1.0 0.9268111995812864 28 O75844,Q15363,P04637,Q9NQC3,O96028 5 +Regulation of systemic arterial blood pressure 0.5083296612294896 0.6314977896642893 0.5277150940138513 1.0 0.9268111995812864 5 P42892,O75787 2 +Long chain fatty acid transport 0.4145991956512244 0.631261859656395 0.527869320712447 1.0 0.9268111995812864 12 P33121,P28288,P31751,P50416,P23786 5 +Collagen metabolic process 0.4218826320696797 0.6269459490903156 0.5306946661696164 1.0 0.9276055698334011 11 Q92791 1 +Regulation of phosphatidylcholine metabolic process 0.5070328058096223 0.6258729934778955 0.5313982496820191 1.0 0.928378970005094 5 Q8WTV0 1 +Signal release 0.3241667564372496 0.6242307634627297 0.5324760462443994 1.0 0.9300124669320924 54 Q4J6C6,Q8NE86,P50897,P62820,P53985,Q9BRT2,Q7L0J3,Q96TA1,P50416,Q5T9L3,Q9UNH7,P40939,Q92543,Q16836,P16615,Q8N5M9 16 +Amyloid beta clearance 0.420816597746845 0.620750632732589 0.534763709451219 1.0 0.9306427014000196 11 Q16850 1 +Axis specification 0.4125374626361437 0.6188817695411348 0.5359942491136924 1.0 0.9308836016704862 12 Q5T9L3,Q9Y2W6,Q15363,Q8N2A8 4 +Regulation of ion transport 0.3085461516685388 0.6185940826552594 0.536183801043236 1.0 0.9308836016704862 79 P30536,P20020,P55011,Q4KMQ2,P05023,Q12959,Q96PU5,O75323,P23634,O14656,P05067,P21796,P27105,Q04656,O76024,O75844,P0CG08,Q99623,Q15041,Q9UNH7,P54709,Q7L0J3,P11413,O75915 24 +Fibroblast proliferation 0.4045526661455316 0.6182583378025289 0.5364050601979633 1.0 0.9308836016704862 13 O75844,P50402,P04637 3 +Sensory system development 0.3500230709712123 0.6172898518339953 0.5370435592571412 1.0 0.9312472581048352 38 Q16706,Q8NF37,O95140,Q8NBN7,Q99471,P54802,Q99797,P20020,O43819,P08670,Q6KCM7,Q12959 12 +Regulation of protein targeting to membrane 0.4120494887927336 0.6159551024857364 0.5379241524478844 1.0 0.9319065248710948 12 Q99828,P31751,P27105 3 +Negative regulation of neuron projection development 0.3696912587554276 0.6153848708787488 0.538300580329365 1.0 0.931938245530344 20 Q9NQC3,Q96G23,Q9NQX7,P08670 4 +Negative regulation of t cell proliferation 0.4842182070020647 0.6147883616700169 0.5386944962726963 1.0 0.9323723768865456 6 P10644 1 +Fatty acid transport 0.3840535200247798 0.6141321186530181 0.5391280254567605 1.0 0.9324484551258718 16 P33121,P28288,O43808,Q9Y3D6,P31751,P50416,P23786 7 +Response to vitamin d 0.5799057926958456 0.6133980163124519 0.5396131973764864 1.0 0.932712777256764 4 Q8TB36 1 +Detection of other organism 0.709537123330219 0.6129738607030192 0.5398936235617995 1.0 0.932712777256764 2 P04439 1 +Protection from natural killer cell mediated cytotoxicity 0.709537123330219 0.6129738607030192 0.5398936235617995 1.0 0.932712777256764 2 P04439 1 +Interferon gamma mediated signaling pathway 0.5797032393061029 0.6126283470987203 0.5401221102761813 1.0 0.9328600647649876 4 P04637 1 +Autophagosome maturation 0.3802849444830054 0.6110123911523566 0.5411913770934018 1.0 0.9334652494928496 17 Q9Y3E7,Q9UQN3,Q9NRR5,P13473,Q9H267,P51809,P16615 7 +Plasma lipoprotein particle clearance 0.4111154373391406 0.6103568525819643 0.5416254436701955 1.0 0.9335339576008204 12 P09601 1 +Retrograde transport vesicle recycling within golgi 0.4671228007726249 0.6100898394561495 0.5418022969032859 1.0 0.9335339576008204 7 Q9UP83,P83436,Q8TBA6,Q14746 4 +Learning 0.3689407635535806 0.6098475046007343 0.5419628296939938 1.0 0.9335635836543194 20 P05067,P04035,P50897,O00264 4 +Response to starvation 0.3496040608347484 0.6047654867825074 0.5453348287807644 1.0 0.9376361509633366 37 P04062,P21964,Q9Y371,P13473 4 +Paranodal junction assembly 0.6902950655746856 0.604059113072596 0.5458043417640075 1.0 0.9376703601189438 3 Q16880 1 +Regulation of phosphatidylinositol 3 kinase signaling 0.4323522175787846 0.6019069001180833 0.547236110939672 1.0 0.9381798255116028 9 O00165 1 +Low density lipoprotein particle clearance 0.4173473499507399 0.6006335994963242 0.5480840539005862 1.0 0.9381798255116028 11 P09601 1 +Regulation of membrane potential 0.3042114312797241 0.6006237668948622 0.548090604357363 1.0 0.9381798255116028 61 O75844,Q9BSK2,Q96PU5,P50148,Q8IWA4,Q14168,P30536,O75915,P05067,P04062,P09622,Q969V5,P31751,P05023,P54709,P16615,Q12959 17 +Cellular response to mineralocorticoid stimulus 0.6889919042615235 0.5996357109866405 0.5487490421529784 1.0 0.93830467617284 3 O95831 1 +Regulation of inflammatory response 0.3488174431760587 0.597802857289897 0.5499714839315493 1.0 0.9393045829106804 37 P53634,Q9H000,Q9BXW9,P04062,P05067,Q86UT6,Q8NCG7,Q9UNH7,Q08722,Q8N2K0,Q99735 11 +Regulation of fat cell differentiation 0.4088479896267646 0.5967882935298878 0.5506487347053715 1.0 0.9393045829106804 12 Q8N4Q0 1 +Positive regulation of protein targeting to membrane 0.4165507027402186 0.5960241412933571 0.5511590993580044 1.0 0.9394659026743478 11 Q99828,P31751,P27105 3 +Peptide transport 0.3522942537510588 0.5915336089230293 0.5541629430217414 1.0 0.940692233922989 31 Q03519,Q8NE86,P62820,P53985,Q03518,P50416,Q9BRT2,P40939,Q92543,Q16836,Q8N5M9 11 +Gtp metabolic process 0.4001761781689791 0.5912021892763544 0.5543849560432159 1.0 0.940692233922989 13 Q8IWA4,Q9UIJ7 2 +Positive regulation of endothelial cell migration 0.3739053253474084 0.5908472364093522 0.5546227818615503 1.0 0.940692233922989 18 P06576,P09601,Q8WTV0 3 +Tumor necrosis factor mediated signaling pathway 0.3919323215823876 0.5901162208400348 0.5551127346591875 1.0 0.9410416979304562 14 Q8TCT8 1 +Potassium ion transport 0.3532805499097249 0.5893427095156398 0.5556313998239744 1.0 0.9410416979304562 23 Q96PU5,Q9BXP2,Q9NUT2,P55011,Q4KMQ2,P05023,P54709,P50570,Q12959 9 +Dna replication checkpoint signaling 0.4981476364607244 0.5875839499305582 0.5568115867021328 1.0 0.9424796514921144 5 Q9Y619 1 +Negative regulation of innate immune response 0.3830820635176896 0.5871710164191394 0.5570888559587293 1.0 0.9424796514921144 15 Q14166,Q969V5 2 +Cellular modified amino acid metabolic process 0.316010879207608 0.5868450913760096 0.5573077497941836 1.0 0.9424796514921144 56 P16435,Q99735,Q9UHG3,Q8TB36,Q9NVH6,Q9H2D1,Q9UJ14,Q9H7Z7,P50416,Q9BVG9,P23786,O60725 12 +Protein folding in endoplasmic reticulum 0.4221237946721744 0.5851474581091648 0.5584485704039577 1.0 0.9431624116020436 10 P27824,Q8IXB1,P07237,Q96HE7 4 +Positive regulation of blood vessel endothelial cell migration 0.4217540283862291 0.583081021489943 0.5598387591013889 1.0 0.9448765255538132 10 P06576,P09601 2 +Copii coated vesicle budding 0.3612193071761229 0.5828966958653619 0.5599628450592615 1.0 0.9448765255538132 21 Q5JRA6,P62820,Q15363,P49755,Q9NR31 5 +Parkin mediated stimulation of mitophagy in response to mitochondrial depolarization 0.7008387698042767 0.5828544179755285 0.5599913079437615 1.0 0.9448765255538132 2 O95140 1 +Epidermis development 0.3370480873897621 0.5805684349680447 0.5615313512600677 1.0 0.9453328286889774 45 O75844,P98194,Q16739,Q13510,P51648,P16615,Q04656 7 +Positive regulation of leukocyte proliferation 0.3787860840013237 0.5785911559502134 0.562865073667802 1.0 0.9453328286889774 16 P30825 1 +Regulation of epidermal growth factor activated receptor activity 0.682096474844671 0.576390207213841 0.5643514620610017 1.0 0.9453328286889774 3 P05067 1 +Negative regulation of g protein coupled receptor signaling pathway 0.4758783711796411 0.5763423279125792 0.5643838178481646 1.0 0.9453328286889774 6 P04899,P23634 2 +Fat soluble vitamin metabolic process 0.4757896472184176 0.5759355542585776 0.5646587426194007 1.0 0.945404213542457 6 P04062 1 +Response to zinc ion 0.4755936501654201 0.5750371384681114 0.5652661801483463 1.0 0.9455276320085708 6 P30536,Q04656 2 +Female sex differentiation 0.4128446570305246 0.574632889739275 0.5655396035047413 1.0 0.9455276320085708 11 O95470 1 +Development of primary female sexual characteristics 0.4128446570305246 0.574632889739275 0.5655396035047413 1.0 0.9455276320085708 11 O95470 1 +Embryonic appendage morphogenesis 0.4128282560788298 0.5745384207619235 0.5656035090289255 1.0 0.9455276320085708 11 Q9NX62 1 +Lipopolysaccharide mediated signaling pathway 0.4270941065847798 0.5734074460144044 0.566368849883236 1.0 0.9460785635520688 9 Q86UE4,Q9UBC1,Q8WTV0 3 +Lipid catabolic process 0.3026248293071834 0.5711684439185079 0.567885466637704 1.0 0.947231711411412 77 Q9H6V9,P06865,P40939,Q16836,Q8WTV0,P50897,P17900,Q8N2A8,Q8NHP8,Q6PIU2,P06280,Q13510,P50416,O95470,Q16134,Q8NBQ5,P04062,Q8NCG7,Q8N2K0,P23786,Q99735,O43808,O15254,A1L0T0 24 +Response to type i interferon 0.3744584472265965 0.5708855301750517 0.5680772401002572 1.0 0.947231711411412 17 Q14166 1 +Cellular response to retinoic acid 0.4193433669345212 0.569630710147473 0.5689281947854308 1.0 0.9476933457594164 10 Q99623 1 +Negative regulation of developmental growth 0.4112614441734118 0.5655219390783757 0.5717188061593161 1.0 0.9477233084946248 11 Q9NQC3,Q13043,P11413,Q15375 4 +Regulation of cell migration involved in sprouting angiogenesis 0.4927434935523019 0.56452254414373 0.5723985619367105 1.0 0.9477233084946248 5 P09601 1 +Positive regulation of cell migration involved in sprouting angiogenesis 0.4927434935523019 0.56452254414373 0.5723985619367105 1.0 0.9477233084946248 5 P09601 1 +Skeletal muscle acetylcholine gated channel clustering 0.4918587816059709 0.5607645769352876 0.5749580378911718 1.0 0.948008412925478 5 P49354 1 +Cellular lipid catabolic process 0.2977463353474625 0.5576401706256848 0.5770901199711052 1.0 0.948008412925478 62 P50897,O95470,Q99735,P17900,Q8NHP8,P06280,P04062,Q13510,P06865,Q8NCG7,O15254,P40939,P23786,Q16836,Q8WTV0 15 +Transepithelial transport 0.490735704878551 0.556001390240578 0.5782099043824962 1.0 0.948008412925478 5 P51798,P55011,P78310 3 +Long term synaptic potentiation 0.4168819508379755 0.5559373083618001 0.5782537125078326 1.0 0.948008412925478 10 Q14168,Q92542 2 +Forebrain neuron differentiation 0.4906559749865868 0.5556635523737623 0.5784408771634961 1.0 0.948008412925478 5 O14949 1 +Forebrain neuron development 0.4906559749865868 0.5556635523737623 0.5784408771634961 1.0 0.948008412925478 5 O14949 1 +Synaptic vesicle localization 0.4093369067894687 0.5544699113919295 0.579257292022461 1.0 0.9487974199039696 11 Q96A57,O00203 2 +Cognition 0.3459833724894264 0.5522814193584931 0.580755558761725 1.0 0.949968992492932 34 P50897,P17900,Q92542,P05067,P04035,O00264 6 +Skin epidermis development 0.393091580970525 0.5476685702027065 0.583919496861246 1.0 0.9514805311626958 13 O75844,Q04656 2 +Positive regulation of protein deacetylation 0.4382871246156167 0.5467853596537584 0.584526202402581 1.0 0.9519927872588172 8 Q9ULX6,Q9UHR5,P49354,P04637 4 +Regulation of plasma lipoprotein particle levels 0.3846888977380476 0.5440996689033422 0.5863728882996959 1.0 0.9532139026000144 14 P09601 1 +Protein transport to vacuole involved in ubiquitin dependent protein catabolic process via the multivesicular body sorting pathway 0.6884125504815141 0.5407874693767093 0.5886540807029772 1.0 0.9550287495553827 2 Q9H3S7 1 +Negative regulation of cysteine type endopeptidase activity 0.3514234492968097 0.5404252370244165 0.5889038073460715 1.0 0.9550287495553827 22 Q15392,Q15041,P51812,P16435 4 +Alcohol catabolic process 0.3991576439083781 0.5391777837029789 0.5897641882264413 1.0 0.955030869696373 12 Q9NX62,Q8WTV0 2 +Positive regulation of reactive oxygen species metabolic process 0.3914330604472389 0.5375294407887591 0.5909019542938505 1.0 0.955922610113226 13 P04637,P51790,P00403 3 +Negative regulation of epithelial cell proliferation 0.3754285671078758 0.5368707814737781 0.5913568749778646 1.0 0.956183546854725 15 P57105 1 +Amyloid fibril formation 0.4358778131055704 0.5345862000152655 0.592936028286557 1.0 0.957808630716904 8 P05067,Q9UHV9,Q99471 3 +Carbohydrate transmembrane transport 0.3747985351458789 0.5327500459526892 0.5942066177216223 1.0 0.957808630716904 15 P52789,Q6ZWJ1,P31751,O75298,Q9UKG1 5 +Negative regulation of amyloid fibril formation 0.4852234836872235 0.5327446825354193 0.5942103309441022 1.0 0.957808630716904 5 Q9UHV9,Q99471 2 +Neurotransmitter transport 0.3462796274030725 0.5321020317640268 0.5946553302722086 1.0 0.957808630716904 26 P50897,O75955,P16615,Q7L0J3 4 +Negative regulation of glial cell proliferation 0.6677676665228458 0.5289985958163874 0.5968064239694493 1.0 0.9583051255195272 3 Q96G23 1 +Negative regulation of toll like receptor signaling pathway 0.5572135486509835 0.5286815460964522 0.597026380808465 1.0 0.9583051255195272 4 Q9NPR9 1 +Polyol catabolic process 0.4344085003062946 0.5271673103754109 0.5980774073178532 1.0 0.9584837977020616 8 Q9NX62,Q10713,Q01968 3 +Protein localization to membrane raft 0.5564963080608318 0.5260574409810478 0.5988482975077021 1.0 0.9587043252946336 4 O75955 1 +Regulation of histone h4 acetylation 0.4495881233098993 0.5254859717122605 0.5992454027751348 1.0 0.9587043252946336 7 O75844,P38398 2 +Granulocyte migration 0.3607869764847763 0.5231397075059355 0.6008770349824111 1.0 0.9594293034666448 19 P84095,Q8NE86,Q8NHP6,P35613,Q8N5M9 5 +Inositol phosphate metabolic process 0.433540695035658 0.5227931345907456 0.6011182177300005 1.0 0.959579154920464 8 Q9NX62,Q96PE3,Q10713 3 +Neurotransmitter secretion 0.3567636462357008 0.520510277140353 0.6027079667650503 1.0 0.9607041085513394 20 P50897,P16615 2 +Negative regulation of cellular response to insulin stimulus 0.4629189691212636 0.5174787816478754 0.6048219770792715 1.0 0.9624018988165088 6 P18031,Q8TBX8,P05771,Q9HCD5 4 +Positive regulation of protein localization to membrane 0.3429819534954301 0.5172253050498814 0.6049988892820801 1.0 0.9624018988165088 32 P98194,P84095,P23634,P27105,P31751,O00264,O14737,O15258,Q99828,Q12959 10 +Muscle cell cellular homeostasis 0.4626186402756694 0.5161286180965311 0.6057645813759671 1.0 0.962748833211731 6 P13473 1 +Leukocyte cell cell adhesion 0.3374478207200484 0.5138492148606165 0.6073574162467881 1.0 0.9645742140978616 39 P10644,Q5JRA6,O00203,P04439,Q12959,Q9HCL2,P30825,Q08722,Q9NUQ9 9 +Appendage morphogenesis 0.3946807308011564 0.5127941587324591 0.6080953162236205 1.0 0.9648385120264537 12 Q9NX62 1 +Execution phase of apoptosis 0.4018329149829883 0.511637951225714 0.6089044194448108 1.0 0.9648385120264537 11 P04637,Q12981 2 +Hemostasis 0.3436509505050479 0.5113898748313108 0.6090780834008127 1.0 0.9648385120264537 27 P38435,Q4KMQ2,Q9BWH2,Q9UIJ7,P53582,O00203 6 +Regulation of systemic arterial blood pressure mediated by a chemical signal 0.6622141428454593 0.5109849128953906 0.6093616211997295 1.0 0.9648385120264537 3 P42892 1 +Cardiac septum morphogenesis 0.4464781032650283 0.5107015139686162 0.6095600804500139 1.0 0.9648385120264537 7 O96028 1 +Positive regulation of atp biosynthetic process 0.5522122614609856 0.5104581847949767 0.6097305024825452 1.0 0.9648385120264537 4 P00403 1 +Positive regulation of nucleotide biosynthetic process 0.5522122614609856 0.5104581847949767 0.6097305024825452 1.0 0.9648385120264537 4 P00403 1 +Interleukin 1 production 0.4086219089820516 0.5103068119715712 0.6098365311306002 1.0 0.9648385120264537 10 P49755,P05067 2 +Axonal transport 0.3623487773524821 0.5099855050480201 0.6100616167604915 1.0 0.9648385120264537 18 O60313,Q14168,O00203 3 +Bradykinin catabolic process 0.5511182852213788 0.5064955612216181 0.6125088049597269 1.0 0.9668408815330408 4 P42892 1 +Polyamine metabolic process 0.6600348101592777 0.5039729075445685 0.6142804154740733 1.0 0.9677601294263352 3 P52788 1 +Peptidyl asparagine modification 0.4138189242182525 0.5023012636751862 0.6154556204642838 1.0 0.9677601294263352 9 P46977 1 +Regulation of carbohydrate catabolic process 0.367083787880639 0.5003528635033111 0.6168266373649411 1.0 0.967988829092062 16 P05067,Q14108,P04637 3 +Positive regulation of neurotransmitter uptake 0.6759863311587423 0.499941140013497 0.6171165231825837 1.0 0.967988829092062 2 P20337 1 +Response to dsrna 0.3666968897193605 0.4977857928065626 0.6186350306914097 1.0 0.96848498136272 16 Q5KU26,Q969V5,O75955 3 +Positive regulation of synaptic vesicle recycling 0.6574769557862753 0.4957849736035033 0.6200461276143394 1.0 0.9695337107967772 3 O14656 1 +Mitotic nuclear membrane organization 0.476223349129001 0.4952345957113016 0.6204345326818652 1.0 0.9695337107967772 5 Q9H6H4 1 +Establishment of mitochondrion localization 0.4123691940139347 0.4946186066085721 0.6208693655465547 1.0 0.9695337107967772 9 Q8IXI1,O60313 2 +Generation of precursor metabolites and energy 0.3920609792469831 0.4945744755070977 0.62090052322023 1.0 0.9695337107967772 187 O14949,Q9BSK2,Q9P0J0,P06576,P52789,P56385,Q9BRR6,Q7KZN9,Q9UDW1,P09622,O43819,P03886,P22695,O43676,O95139,P22830,O43175,P14406,O14548,P24539,O75323,P00403,P05067,Q13423,O15460,Q6KCM7,Q04656,P16435,P48163,Q99623,Q9H3K2,P35573,P13073,O95168,Q15070,O95299,P04062,O96000,O75964,Q9Y6M9,O75208,P21912,Q9UJS0,O75746,P04637,P10253,P51970,P12235 48 +Response to calcium ion 0.341039963897473 0.4931341454552347 0.6219178056955545 1.0 0.9704242138225077 23 Q6NUK1,Q92542,Q9UJS0 3 +Regulation of tolerance induction 0.6562340119031874 0.491822780065579 0.6228446311254019 1.0 0.9713702745637282 3 P01889 1 +Establishment of protein localization to plasma membrane 0.3450471369642897 0.4916859070049655 0.6229414025171691 1.0 0.9713702745637282 22 P61026,P98194,Q15904,Q9BZG1,Q8N2H4 5 +Response to mineralocorticoid 0.4421426769788961 0.4902169565667297 0.6239803831618178 1.0 0.9722450324241434 7 O95831,P07196 2 +Negative regulation of response to endoplasmic reticulum stress 0.3835735884201 0.4897852618302867 0.6242858608700503 1.0 0.972488354902329 13 O60313,O76024,Q04323 3 +Positive regulation of epithelial to mesenchymal transition 0.4748134328358128 0.4894137088545798 0.6245488325297117 1.0 0.9726653625695868 5 P35222,Q12948,Q92769,P42345 4 +Forebrain generation of neurons 0.4563101640456305 0.4879274086445984 0.6256012596831002 1.0 0.9733765007859244 6 O14949 1 +T cell tolerance induction 0.6719478098788407 0.4869458248985995 0.6262967233179404 1.0 0.9735251930715384 2 P01889 1 +Lymphocyte anergy 0.6719478098788407 0.4869458248985995 0.6262967233179404 1.0 0.9735251930715384 2 P01889 1 +Superoxide metabolic process 0.4412153561732954 0.4858551200477812 0.6270698905123244 1.0 0.9740296200588524 7 P04899,Q04656 2 +Urogenital system development 0.3207416756118849 0.4854826539478675 0.6273340142075075 1.0 0.9741083686326666 49 O75844,P07602,Q9NZJ7,P39210,O95470,O76024 6 +Export from cell 0.3547093115226322 0.4851699313422127 0.6275558093984559 1.0 0.9741083686326666 140 Q4J6C6,O15498,Q8NE86,Q96PC5,Q9Y3E7,P04899,Q9UPT5,P20020,Q86YV9,P55011,Q4KMQ2,Q5T9L3,P05023,Q92905,P40939,Q9UBV2,P51809,P16615,Q12959,P61026,Q99584,O15126,P50897,Q16836,P09601,Q96KC8,Q9HCU5,Q96TA1,P50416,Q16850,P35670,Q9BRK5,Q5JRA6,P11279,P62820,O43760,P53985,Q6ZWJ1,P27824,Q68EM7,Q9BRT2,Q9UNH7,P54709,Q92543,Q8N5M9,P49755,Q7L0J3,P04035,Q8TBQ9,Q32P28 50 +Response to cadmium ion 0.3827403262320766 0.4847549882876665 0.6278501553086482 1.0 0.9742859662345928 13 O15118,P09601,Q04656 3 +Maintenance of protein location 0.3392257643057021 0.4797767435068601 0.6313861514285195 1.0 0.9747556293271836 30 P52789,Q9UH99,P24390,O15258,Q96RL7 5 +Pore complex assembly 0.3816134249514193 0.4779623377564664 0.6326770112531004 1.0 0.9755268405046028 13 Q9NQC3,Q9BTX1 2 +Negative regulation of tubulin deacetylation 0.6688412550481487 0.4770466569105189 0.6333288982507417 1.0 0.976069833011614 2 Q13131 1 +Regulation of fatty acid transport 0.4715925010909501 0.4761750690673557 0.6339496593600273 1.0 0.976173172895872 5 P33121,Q9Y3D6,P31751 3 +Glycoprotein catabolic process 0.6679092885989397 0.4740936621375322 0.6354331179528261 1.0 0.9774624225854408 2 O60502 1 +Positive regulation of protein catabolic process 0.2830455394165919 0.4718416680615487 0.637039806659127 1.0 0.978294874251898 66 Q9P0J0,Q96PU5,Q96HY6,P53634,Q9H000,P46379,Q4ZIN3,O43765,P51572,O75396,P04062,P14735,P54725,O43847,Q9Y5A7,Q8NF37 16 +Regulation of intracellular estrogen receptor signaling pathway 0.380430558876849 0.470845321676287 0.6377511969728284 1.0 0.978294874251898 13 Q96HY6,Q99623 2 +Alpha beta t cell proliferation 0.6472964574269654 0.4636609039079311 0.6428907119492588 1.0 0.9835910751528124 3 Q96J02,P04439 2 +Negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway 0.3929137298572804 0.461336162027312 0.6445574443069901 1.0 0.9835976063961092 11 Q9UNH7,Q92896,P04637,Q9UNE7 4 +Monosaccharide catabolic process 0.3633594850358783 0.4585496652861659 0.6465575895688902 1.0 0.9846276918103636 15 O75746,P16278,P52789,P04637 4 +Cell activation 0.3411347327453172 0.4575448342373318 0.6472794845467993 1.0 0.9848272910306765 127 P46379,Q9BXW9,Q9NQT5,P53582,P05141,P78310,Q92542,Q5HYI8,Q12959,Q99584,P10644,P09601,P24390,P04439,O96028,P05067,Q04656,Q9NUQ9,P11279,P0CG08,Q99623,P30825,P04062,O96005,P55327,Q9BWH2,Q9UNH7,Q96L92,P49366,P04637,Q9HCL2,Q08722,P35232,Q96FV9,O00203 35 +Semi lunar valve development 0.4485225505443168 0.4535596044534127 0.6501458338017756 1.0 0.985971810353135 6 O94813,Q9Y6N7,Q04721,Q06330,O75116 5 +Heart valve morphogenesis 0.4485225505443113 0.4535596044533881 0.6501458338017934 1.0 0.985971810353135 6 O94813,Q9Y6N7,Q04721,P42345,O75116 5 +Negative chemotaxis 0.643721829355257 0.4525640002753553 0.650862726290351 1.0 0.9862887241342616 3 Q15375 1 +Oogenesis 0.3532759917275477 0.4473088647261014 0.654652067312937 1.0 0.989644887467006 18 Q12768,Q8N2A8 2 +Fat cell differentiation 0.3350317430129614 0.4423905755466704 0.6582065976615512 1.0 0.9915840701510504 26 Q96HE7,Q8N4Q0,Q9NZ08,O75962,P31751,Q8TDW0,Q9BRK5 7 +Netrin activated signaling pathway 0.6401290988137484 0.4415101905907841 0.6588436856736006 1.0 0.9915840701510504 3 Q13509 1 +Regulation of cellular response to transforming growth factor beta stimulus 0.3893356877099682 0.4413661583323802 0.6589479377842911 1.0 0.9915840701510504 11 Q9UNH7,Q92896,P04637,Q9UNE7 4 +Transport along microtubule 0.31445217458934 0.4402306900548441 0.6597700339703183 1.0 0.9915840701510504 50 O60313,Q8IXI1,P11279,P62820,P23246,P07196,Q14168,Q8TD16,A0AVF1,P05067,O75381,Q5SNT2,O00203 13 +Eosinophil mediated immunity 0.6567256912084446 0.4392791275109138 0.6604592962346834 1.0 0.9915840701510504 2 P51809 1 +Eosinophil activation 0.6567256912084446 0.4392791275109138 0.6604592962346834 1.0 0.9915840701510504 2 P51809 1 +Positive regulation of cell cell adhesion 0.3334167566463851 0.4372676884566804 0.6619172255245371 1.0 0.9919112908957628 32 O00203,P04439,Q9HCL2,P30825,O75955,Q08722,Q9NUQ9 7 +Negative regulation of protein localization 0.3190008629275123 0.4365090758950499 0.6624674157521393 1.0 0.9919112908957628 47 Q96PU5,P04035,Q10713,Q16850,P40939,Q9GZP9,Q8N5M9 7 +Receptor clustering 0.3673942834426455 0.4360025765381619 0.6628348601907308 1.0 0.9919295854959894 14 Q14168,O15258,P57105,P49354 4 +Peptidyl proline modification 0.3334089536617458 0.434324195458947 0.6640530361827053 1.0 0.9923149720140524 31 Q9NWM8,Q96HE7,Q96AY3,P13674,P07237,P26885,Q9BV86,O15460,Q9Y680,Q32P28 10 +Organic hydroxy compound metabolic process 0.3292836020411714 0.4342134874512686 0.6641334197772539 1.0 0.9923149720140524 116 P38435,Q15392,Q9NX62,O15269,Q15800,Q10713,Q8WTV0,P05067,Q13510,P51648,Q16850,O15118,Q04656,P16435,Q14534,P04062,P61916,Q15125,Q14739,Q8NBN7,P37268,P04035,P21964 23 +Glucose import 0.3807998524404891 0.4321157203453685 0.6656573096725951 1.0 0.9927376402380138 12 O75298,P31751,P52789,Q9UKG1 4 +L aspartate transmembrane transport 0.6368290655706241 0.4314465753308972 0.6661436905192142 1.0 0.9927649700701128 3 Q9UJS0 1 +3 phosphoadenosine 5 phosphosulfate metabolic process 0.5283576155392504 0.4261368715819349 0.6700081142059777 1.0 0.9962080485846188 4 Q8TB61 1 +Positive regulation of epithelial cell proliferation 0.3324844844141182 0.4246418635657919 0.6710977702416692 1.0 0.9963418814574416 24 Q9NQC3 1 +Membrane docking 0.3319936415522731 0.4226812513079265 0.6725278364736029 1.0 0.9967520531489308 31 Q86Y82,O15498,O60499,O15400,P16615 5 +Pulmonary valve morphogenesis 0.6326457275115043 0.4188154888011757 0.6753509842271672 1.0 0.9985382429674324 3 Q04721 1 +Negative regulation of tor signaling 0.5259558594964339 0.4179069120800648 0.6760151786448576 1.0 0.9990162344537654 4 P54646,O75340,Q13131 3 +Regulation of t cell differentiation 0.3778883585514461 0.4154396288542394 0.6778201013483356 1.0 0.9994501788546004 12 O96005,O00203 2 +Negative regulation of alpha beta t cell proliferation 0.6470953712332974 0.4102573716718808 0.6816171590882554 1.0 1.0 2 Q96J02 1 +Ornithine metabolic process 0.6470953712332967 0.4102573716718784 0.6816171590882572 1.0 1.0 2 P54886 1 +Carbohydrate catabolic process 0.3113801287676488 0.4095755168374982 0.6821173599133536 1.0 1.0 50 P16278,P52789,P17900,Q9BRR6,P35573,P04637,P10253,P05067,Q14108,Q9NUJ1 10 +Regulation of er associated ubiquitin dependent protein catabolic process 0.6290976762088102 0.4082156345182636 0.6831153708474822 1.0 1.0 3 P51572 1 +Positive regulation of vasculature development 0.3502152919296842 0.4069427322293795 0.6840500497352311 1.0 1.0 17 Q9NZ08,P52789,P09601,Q86UE4 4 +Blood vessel endothelial cell migration 0.329821741940791 0.4061569269601689 0.6846273002018288 1.0 1.0 23 P06576,Q5JRA6,P09601,P23634,Q99828,Q8WTV0 6 +Regulation of long term synaptic potentiation 0.4375464419260548 0.4060459657697527 0.6847088268516806 1.0 1.0 6 Q92542 1 +Actin mediated cell contraction 0.349841698505096 0.4044648087418833 0.6858709509745218 1.0 1.0 17 Q9UM22,Q96PU5,P16615 3 +Aging 0.2991330298119795 0.4037934482120383 0.686364614790163 1.0 1.0 56 O60313,O75844,P02545,Q13144,P53634,Q96HE7,Q9NX47,Q9UGP8,P04637,P30536,P27824,P05067,P20020,P04062,P55011 15 +Regulation of mononuclear cell migration 0.3464785101159903 0.4009311899237061 0.6884707857078585 1.0 1.0 18 P05067,Q08722,Q5JRA6,Q4KMQ2 4 +Embryonic brain development 0.5203605843954073 0.3989342640369035 0.6899416414312816 1.0 1.0 4 Q9BVA1,P27635,P62995 3 +Metanephric nephron development 0.5203605843954036 0.3989342640368908 0.6899416414312909 1.0 1.0 4 P11047,O95747,P42224 3 +Cell differentiation involved in metanephros development 0.5203605843954036 0.3989342640368908 0.6899416414312909 1.0 1.0 4 P11047,O95747,P42224 3 +Positive regulation of histone h3 k9 methylation 0.5200252982212782 0.3978064574354065 0.6907728569379703 1.0 1.0 4 P02545 1 +Positive regulation of fibroblast migration 0.6253118835391601 0.3970225615742704 0.69135082329489 1.0 1.0 3 O95429 1 +Regulation of histone h4 k16 acetylation 0.5194761102212248 0.3959614037656248 0.6921335014141587 1.0 1.0 4 P38398,O75844 2 +Spermatid differentiation 0.3393526744538577 0.3950461624805129 0.6928088201136013 1.0 1.0 20 Q9GZT3,Q8N2A8,P09622,Q15645,Q99828 5 +Regulation of rna polymerase ii regulatory region sequence specific dna binding 0.6242194242617318 0.3938154267052504 0.6937173140640609 1.0 1.0 3 O75844 1 +Regulation of lymphocyte activation 0.3023255405736645 0.3933163444069604 0.6940858479242822 1.0 1.0 54 P10644,P49366,P11279,Q9BXW9,Q9NQT5,P04439,O00203,Q9HCL2,Q9NUQ9,O96028,P30825,O96005,Q08722,Q12959 14 +Progesterone receptor signaling pathway 0.4507576251110035 0.3927173571920473 0.6945282493912108 1.0 1.0 5 P35232 1 +Positive regulation of glucose metabolic process 0.4506448844930937 0.3922769000647595 0.6948536297249539 1.0 1.0 5 O75746 1 +Positive regulation of cellular carbohydrate metabolic process 0.4506448844930937 0.3922769000647595 0.6948536297249539 1.0 1.0 5 O75746 1 +Response to interleukin 1 0.3671284355302293 0.3918212716137417 0.6951902767823679 1.0 1.0 13 Q08722 1 +Positive regulation of tor signaling 0.4200026641895832 0.3882101730693714 0.6978605053825813 1.0 1.0 7 Q15382,Q6IAA8,Q9NWS0 3 +Microtubule based transport 0.3072559572836973 0.3857878360367174 0.6996538046955441 1.0 1.0 51 O60313,Q8IXI1,P11279,P62820,P23246,P07196,Q14168,Q8TD16,A0AVF1,P05067,O75381,Q5SNT2,O00203 13 +Endocytosis 0.3261058840708692 0.3856926468717228 0.6997243092283121 1.0 1.0 117 Q96PU5,P50897,Q5JRA6,Q9NX40,Q96ED9,P27824,Q5VW38,Q5KU26,P05067,O75955,Q6UWE0,Q9Y5X3,Q14108,O60749,P57105,P51790,O15118,Q8WTV0 18 +Cellular response to virus 0.334557143628985 0.3852345132218643 0.7000636750031775 1.0 1.0 21 Q9NUD5,Q86UT6,O43657,Q99623 4 +Golgi organization 0.3033790215139885 0.3838747351423138 0.7010712928341802 1.0 1.0 53 Q9Y6Y8,O14578,Q8NHH9,Q9BVK6,Q15363,P62820,P49755,Q9BTU6,O75396,Q9P2W9,Q8TBA6,Q14789,Q9Y3B3 13 +Negative regulation of helicase activity 0.6204258820167755 0.3827594205275219 0.7018981520302834 1.0 1.0 3 P04637 1 +Liver regeneration 0.3846251219402477 0.3812093540537536 0.7030479087157071 1.0 1.0 10 P09601 1 +Regulation of cell cell adhesion 0.3081077107856486 0.3770648592100967 0.7061254053075339 1.0 1.0 50 P10644,Q5JRA6,O00203,P04439,Q12959,Q9HCL2,P30825,O75955,Q15375,Q08722,Q9NUQ9 11 +Response to hydrogen peroxide 0.3257912065128661 0.3728803834979877 0.7092374725239874 1.0 1.0 24 P09601 1 +Regulation of leukocyte proliferation 0.3257921608132154 0.3710351881922073 0.7106113229897768 1.0 1.0 25 P10644,P04439,Q9HCL2,P30825,Q12959 5 +Intraciliary transport involved in cilium assembly 0.6151514410010498 0.3675996036940736 0.7131718103716933 1.0 1.0 3 A0AVF1 1 +Meiotic cell cycle process 0.3223121577830237 0.3661997654728632 0.7142160171789558 1.0 1.0 37 P46379,Q9BXW9,Q92791,Q9BZD4,Q12768,Q9BTX1,Q15645,O60566 8 +Eye morphogenesis 0.375419230141027 0.3650170556979438 0.7150986747697992 1.0 1.0 11 Q16706,O95140,Q8NBN7,P54802,Q15555 5 +Neuron projection regeneration 0.3813880821701333 0.3642722162023348 0.7156547449585715 1.0 1.0 10 Q96G23,P07196 2 +Regulation of neutrophil chemotaxis 0.4144368388301313 0.363350280657351 0.7163432375913188 1.0 1.0 7 Q8NE86,Q00013,Q8NHP6,O94813,O00429,Q07021 6 +Positive regulation of cold induced thermogenesis 0.3808747241317066 0.3615981193335963 0.7176523702580277 1.0 1.0 10 O95140,P40939,P23786,Q16836,O00767 5 +Positive regulation of defense response 0.3193040394778519 0.3608122667062111 0.7182397921616235 1.0 1.0 40 P11279,P23246,Q9NUD5,Q8WXF1,Q15233,P05067,Q6UWE0,Q08722,Q99735 9 +Appendage development 0.3549157432458231 0.3600145770461203 0.718836232568342 1.0 1.0 14 Q9NX62 1 +Negative regulation of protein tyrosine kinase activity 0.4421196915795067 0.3593527353640818 0.719331228152448 1.0 1.0 5 O95684 1 +Regulation of developmental growth 0.2989863399341644 0.358510275174193 0.719961479760558 1.0 1.0 54 O75844,Q96PU5,Q9HCL2,Q9NQC3,Q969V5,O95470 6 +Adaptive thermogenesis 0.3239147205549218 0.356521120006016 0.7214503383462825 1.0 1.0 25 P33121,Q15382,Q96H78,Q9UIQ6,O95140,P05141,P12235,O43847,P40939,P23786,Q16836,O00767 12 +Cellular lipid metabolic process 0.3996196555902317 0.3560860472687482 0.7217761259829496 1.0 1.0 216 Q8N4Q0,Q15800,Q5T8D3,P50897,P07602,P17900,Q6PIU2,Q13510,P51648,O95470,O75844,Q16739,Q16134,P04062,Q96PE3,Q8N2K0,O00767,Q9HB40,Q86YN1,Q9BTU6,Q9HCL2,Q9NZJ7,O43808,Q96S52,P31751,Q8N5B7,Q5H8A4,Q06136,Q9BT22,Q9NX62,P35790,Q96G23,Q9UKU0,P40939,Q9UBV2,Q8WTV0,Q9P035,Q99623,Q16880,Q9UG56,P37268,Q8NBX0,Q9NPH0,P04035,Q53H12,O15254,Q8NF37,Q96AA3,O15269,Q10713,Q9NZ01,Q16836,O95674,P16278,P06280,Q9H7Z7,Q9BVG9,P16435,Q53GQ0,P61916,Q8NCG7,P23786,Q99735,Q8NBN7,O00116,Q96N66,P06865,Q92604,Q92643,Q9Y394,Q8NHP8,Q9NUQ2,P50416,P48651,Q9NTJ5,Q9Y263,O94905,P38398,A1L0T0,P14324,Q2TAA5 81 +Membrane biogenesis 0.3232631909674713 0.3560139335283431 0.721830130486909 1.0 1.0 23 Q9H6H4,Q96CP7,Q16739 3 +Sulfur amino acid metabolic process 0.3786563554527848 0.3500812452343451 0.7262777255358874 1.0 1.0 10 Q13126 1 +Positive regulation of intracellular protein transport 0.2959645005023023 0.3477721567822817 0.7280113016068626 1.0 1.0 55 Q9Y282,P50402,P51572,Q9NR31,Q9Y371,P55786,Q9C0E2,P27105,P31751,O14737,Q99828 11 +Negative regulation of intrinsic apoptotic signaling pathway 0.322295583495387 0.3456483658112395 0.7296069930756155 1.0 1.0 32 Q9P0J0,O60313,P45880,Q07820,O76024 5 +Positive regulation of ossification 0.4373889703051447 0.3414220106513612 0.7327859074138836 1.0 1.0 5 P20020 1 +Regulation of endothelial cell migration 0.3221546429123589 0.3404880174368027 0.7334890450296871 1.0 1.0 27 P06576,P09601,P23634,Q99828,P57105,Q8WTV0 6 +Negative regulation of immune response 0.3220478865174306 0.3394350621781453 0.7342820089350646 1.0 1.0 29 Q14166,Q969V5,P09601 3 +Cellular carbohydrate metabolic process 0.2763127055408219 0.3359089068462258 0.7369395602488504 1.0 1.0 63 O75844,P16278,P52789,Q8N6G5,P04637,Q9NX62,Q7LGA3,Q10713,Q14108,Q9NUJ1 10 +Regulation of innate immune response 0.3053853942431737 0.3344643028456874 0.7380292235778723 1.0 1.0 49 P11279,P23246,Q9NZ08,P04439,Q8WXF1,Q86UT6,Q14166,Q969V5,Q9NUD5 9 +Negative regulation of erad pathway 0.6027620504052467 0.3329981238901503 0.7391356993374938 1.0 1.0 3 Q04323 1 +Olfactory bulb interneuron differentiation 0.6188257222739904 0.3306276162961296 0.7409257835333247 1.0 1.0 2 O94813 1 +Roundabout signaling pathway 0.6188257222739904 0.3306276162961296 0.7409257835333247 1.0 1.0 2 O94813 1 +Cerebral cortex tangential migration 0.6188257222739904 0.3306276162961296 0.7409257835333247 1.0 1.0 2 O94813 1 +Regulation of chemokine mediated signaling pathway 0.6188257222739904 0.3306276162961296 0.7409257835333247 1.0 1.0 2 O94813 1 +Olfactory bulb interneuron development 0.6188257222739904 0.3306276162961296 0.7409257835333247 1.0 1.0 2 O94813 1 +Negative regulation of chemokine mediated signaling pathway 0.6188257222739904 0.3306276162961296 0.7409257835333247 1.0 1.0 2 O94813 1 +Torc2 signaling 0.6000377227632967 0.3255857873922579 0.7447377667854651 1.0 1.0 3 Q9NWS0 1 +Centriole assembly 0.3793093031368674 0.3251437036502862 0.7450723136111486 1.0 1.0 9 P41208 1 +Carbohydrate derivative biosynthetic process 0.3604132022700626 0.3239785075491944 0.7459543059060789 1.0 1.0 164 P06576,P56385,Q8N6G5,Q9BT22,Q92542,Q96AA3,Q7LGA3,P09622,P06865,Q9UIJ7,Q9UKU0,P53007,Q9NZ01,Q92643,Q8WVC6,P50897,Q8N4A0,P24539,Q8TB61,P00403,Q9NQX7,O15118,Q04656,Q16739,Q53GQ0,Q16880,O75964,Q9UJS0,Q86YN1,Q8NCH0,Q8NBX0,O43252,Q10472,P16260,Q13126,Q5H8A4,P46977 37 +Posttranslational protein targeting to membrane translocation 0.497291024900727 0.3239061689480736 0.7460090734205569 1.0 1.0 4 Q99442 1 +Cellular defense response 0.5987663237781774 0.3221514246997395 0.7473379818154511 1.0 1.0 3 Q08380 1 +Homeostasis of number of cells 0.2848894591220289 0.3215565544068579 0.7477886615775691 1.0 1.0 59 P04062,Q9NX40,Q9HCL2,P09601 4 +Axo dendritic transport 0.3188317287682298 0.317496946422078 0.7508665561170216 1.0 1.0 25 O60313,P23246,P07196,Q14168,O00203,P05067,Q9Y496,Q14254,P33176 9 +Collateral sprouting 0.4945513956249274 0.3153635691267011 0.7524856242082278 1.0 1.0 4 P05067 1 +Positive regulation of neutrophil migration 0.4295570060719874 0.3123034600235958 0.7548099107498061 1.0 1.0 5 Q8NE86 1 +Positive regulation of granulocyte chemotaxis 0.4295570060719874 0.3123034600235958 0.7548099107498061 1.0 1.0 5 Q8NE86 1 +Purinergic nucleotide receptor signaling pathway 0.5944462942386008 0.3106016383223317 0.7561034815538574 1.0 1.0 3 Q4KMQ2 1 +Metanephric glomerulus development 0.6110593351972579 0.3103061829549324 0.7563281297516606 1.0 1.0 2 P11047 1 +Regulation of establishment of planar polarity 0.4143079315707526 0.3096378550706501 0.7568363659018256 1.0 1.0 6 Q9ULK5,Q13308,O95487,Q8TAA9,P60953 5 +Angiogenesis involved in wound healing 0.5937940592387109 0.3088740785821731 0.7574173156091724 1.0 1.0 3 P55011 1 +Regulation of extrinsic apoptotic signaling pathway 0.3161528284834012 0.3086731700189781 0.7575701550502072 1.0 1.0 36 Q9NQX7,P61289,P02545,P09601 4 +Intermediate filament organization 0.4136308307496231 0.306924966255291 0.7589004853258534 1.0 1.0 6 P08670,P07197 2 +Positive regulation of epithelial cell migration 0.317704087160326 0.3052205469316876 0.7601981843977212 1.0 1.0 28 Q9NQC3,P09601 2 +Germ cell migration 0.592315112556044 0.3049727391031556 0.7603869149267 1.0 1.0 3 P78310 1 +Multicellular organismal signaling 0.3164042814266563 0.3013806350478795 0.7631242592518053 1.0 1.0 24 O75844,P04062,P16615 3 +Regulation of metal ion transport 0.2951142215684625 0.2993303070444075 0.7646880323685004 1.0 1.0 53 Q96PU5,O76024,O75323,P23634,P30536,P20020,P21796,Q4KMQ2,P27105,P05023,P11413,P54709,Q04656,Q12959 14 +Ribose phosphate biosynthetic process 0.284194186788723 0.2974984190420427 0.7660860148103419 1.0 1.0 81 Q8WVC6,P06576,P50897,Q9UJS0,P56385,P24539,Q8TB61,Q53GQ0,P00403,P09622,O43252,O75964,Q9UIJ7,P16260,Q9UKU0,Q9NZ01 16 +Nadp metabolic process 0.344275539995377 0.2969209698759864 0.7665268461038388 1.0 1.0 14 Q13423,P48163 2 +Positive regulation of reactive oxygen species biosynthetic process 0.4879399350135998 0.2950920872693647 0.7679235341750652 1.0 1.0 4 P51790 1 +Copii coated vesicle cargo loading 0.3731190226151226 0.2948920919292041 0.7680763131924389 1.0 1.0 9 Q5JRA6,Q9NR31 2 +Odontogenesis 0.3561995018099525 0.2945569229598613 0.7683323732882519 1.0 1.0 12 Q6P4Q7,P35613 2 +Regulation of response to wounding 0.3278245378734138 0.2942360280838958 0.768577552049277 1.0 1.0 19 Q96G23,P55011,Q04656 3 +Regulation of peptidyl tyrosine phosphorylation 0.3157180662328975 0.2938044213007867 0.7689073564136577 1.0 1.0 25 P14174,O00165,P04637,P05067,O95684,Q9H223,Q15375,Q9UNH7 8 +T cell mediated immunity 0.3619793584574379 0.2936316599949951 0.7690393805040618 1.0 1.0 11 P04439,O15400,Q9NUQ9 3 +Regulation of transmembrane transport 0.2756062654004082 0.292008387530636 0.7702802110062463 1.0 1.0 73 P52789,Q4KMQ2,Q12959,Q96PU5,Q9P2B4,O75323,P23634,P05067,P21796,P27105,Q04656,O75844,P0CG08,Q99623,O75298,Q15041,P54709,P31751,O75915 19 +Collagen fibril organization 0.3611296519490831 0.289207282572032 0.7724227591853203 1.0 1.0 11 P13674,Q92791,Q04656 3 +Regulation of muscle hypertrophy 0.3551206775825556 0.2887199688133289 0.772795680272155 1.0 1.0 12 P02545,P23634 2 +Regulation of dna methylation 0.3660980964983014 0.2861555757584291 0.774758967026699 1.0 1.0 10 O75844,P38398 2 +Secretion 0.3476089568329492 0.2857068960249838 0.7751026225082855 1.0 1.0 152 Q4J6C6,O15498,Q8NE86,P52789,Q96PC5,Q9Y3E7,P04899,Q9UPT5,Q86YV9,P55011,Q5T9L3,Q92905,P40939,Q9UBV2,P51809,P16615,O15126,P61026,Q99584,Q16836,P50897,Q9Y5X3,P09601,Q96KC8,Q13505,P00403,Q9HCU5,Q96TA1,Q9H7Z7,P50416,Q16850,P35670,Q04656,Q9BRK5,Q5JRA6,P11279,P62820,O43760,P53985,Q6ZWJ1,P55327,Q68EM7,P27824,Q9BRT2,Q9UNH7,Q92543,Q8N5M9,P49755,Q7L0J3,P04035,Q8TBQ9,Q32P28 52 +Response to carbohydrate 0.311235712114119 0.2833144538865664 0.7769357984053795 1.0 1.0 39 Q5KU26,Q9HCL2,Q8N5M9,Q15043 4 +Regulation of blood circulation 0.3140955310040096 0.2815271908636764 0.7783060757718276 1.0 1.0 25 O75844,P42892,P10253,P20020,P05023,P16615,Q12959 7 +Positive regulation of dna ligation 0.5992544268406246 0.2807806343867425 0.7788786578736435 1.0 1.0 2 P18887 1 +Negative regulation of endoplasmic reticulum stress induced intrinsic apoptotic signaling pathway 0.3952692363879029 0.280624209774693 0.7789986451735791 1.0 1.0 7 O76024 1 +Glycolytic process through fructose 6 phosphate 0.3649461839724124 0.2804081398584786 0.7791643927529535 1.0 1.0 10 Q9BRR6 1 +Negative regulation of cell activation 0.3250730969283495 0.2758405039875426 0.7826705724250942 1.0 1.0 19 P10644,P09601,Q12959 3 +Regulation of viral induced cytoplasmic pattern recognition receptor signaling pathway 0.3814824826697054 0.2739226592985776 0.7841440577464402 1.0 1.0 8 Q86UT6,O43657 2 +Heart process 0.3133077816218927 0.2708875398201968 0.7864775286409906 1.0 1.0 30 O75844,Q96PU5,P04899,P23634,P10253,P20020,P05023,P16615,Q12959 9 +Pulmonary valve development 0.479328566987887 0.2694445953952473 0.7875875724480803 1.0 1.0 4 O94813,Q9Y6N7,Q04721 3 +Mesenchyme morphogenesis 0.4793285669878849 0.2694445953952409 0.7875875724480852 1.0 1.0 4 Q12948,Q9Y6N7,O95747 3 +Positive regulation of jnk cascade 0.3920622565810326 0.2672652768542079 0.7892649196684349 1.0 1.0 7 P05067 1 +Regulation of protein stability 0.3093718673473965 0.2644061348085401 0.7914669847980866 1.0 1.0 110 Q86Y82,Q969V3,P46379,Q9NQC3,Q5HYI8,P10619,P40855,Q9UBV2,Q96PU5,Q9BUN8,O76024,P02545,P11279,Q99623,Q9Y371,Q969V5,Q96HY6,P04637,O75955,P13473,P54725,P35232 22 +Positive regulation of erk1 and erk2 cascade 0.3281587299623899 0.2641267911636356 0.7916822203435354 1.0 1.0 17 Q13641,Q99623,P04899,Q04721,P05067,Q99828,P35232 7 +Polysaccharide metabolic process 0.3175892815952297 0.2641097069749318 0.791695384303913 1.0 1.0 21 Q8N6G5,P35573,P10253,Q7LGA3,P46020,P31751 6 +Cellular senescence 0.3301851605219113 0.2636977082445633 0.7920128616056055 1.0 1.0 16 O75844,P04637 2 +Cellular carbohydrate biosynthetic process 0.3301554505431331 0.2635155627199999 0.792153230002095 1.0 1.0 16 Q8N6G5 1 +Regulation of endoplasmic reticulum stress induced intrinsic apoptotic signaling pathway 0.3788095986450756 0.2620562407977179 0.7932780828674029 1.0 1.0 8 O76024 1 +Regulation of atp biosynthetic process 0.4019440989150306 0.2610611174182915 0.7940453759673503 1.0 1.0 6 P00403 1 +Interferon gamma production 0.3784819860874845 0.2606092937685858 0.7943938219035718 1.0 1.0 8 P04439,Q08722 2 +Regulation of excretion 0.5747182939789532 0.2602953105543285 0.7946359896055113 1.0 1.0 3 Q9Y5X3 1 +Positive regulation of nf kappab transcription factor activity 0.3118036163217197 0.2591003159620204 0.795557841019018 1.0 1.0 30 Q86UE4,P05067,O75955,Q99828,O60858 5 +Non canonical wnt signaling pathway 0.414179104477603 0.2573531546633174 0.7969061623512188 1.0 1.0 5 Q9ULK5,Q13308,P60953,Q8TAA9 4 +Response to thyroxine 0.589313451382407 0.2572316341274202 0.7969999649186434 1.0 1.0 2 P48506 1 +Response to l phenylalanine derivative 0.589313451382407 0.2572316341274202 0.7969999649186434 1.0 1.0 2 P48506 1 +Protein quality control for misfolded or incompletely synthesized proteins 0.3492378142061264 0.2572272163103457 0.7970033751183627 1.0 1.0 12 Q96TA2,O14656,P46379,Q9BUN8 4 +Muscle system process 0.2832369454025654 0.2563828826007748 0.7976552039568685 1.0 1.0 57 Q96PU5,P02545,P09601,P50402,P10253,P20020,O43819,P05023,P67936,P16615,Q12959 11 +Negative regulation of nervous system development 0.3220777733343072 0.2559741891234074 0.7979707675897698 1.0 1.0 19 Q9NQC3,P04637,Q96G23 3 +Osteoclast development 0.4122221722337372 0.2505860662216047 0.8021341556165882 1.0 1.0 5 Q15904 1 +Negative regulation of erk1 and erk2 cascade 0.3278568498729058 0.2494743765504932 0.8029938589825076 1.0 1.0 16 Q99956,P56537,P57105,P35232,Q96P70,Q12959 6 +Monovalent inorganic anion homeostasis 0.569313687629573 0.2472387974371924 0.8047234210917138 1.0 1.0 3 P55011 1 +Regulation of heterotypic cell cell adhesion 0.5687802859870781 0.2459676315873209 0.805707289111476 1.0 1.0 3 O75955 1 +Regulation of toll like receptor 3 signaling pathway 0.5687802859870781 0.2459676315873209 0.805707289111476 1.0 1.0 3 O75955 1 +Peripheral nervous system development 0.341396437462285 0.2456559942855071 0.8059485398827648 1.0 1.0 13 Q16880,P51648 2 +Cell cell adhesion via plasma membrane adhesion molecules 0.335278900612678 0.2450302552609096 0.8064330049839445 1.0 1.0 14 P35613 1 +Extrinsic apoptotic signaling pathway 0.3032963216041085 0.244233728077203 0.8070498066198815 1.0 1.0 43 Q9P0J0,P02545,P09601,P61289,Q9NQX7 5 +T cell activation involved in immune response 0.3622960445195834 0.2433893053341688 0.80770382786848 1.0 1.0 9 Q04656 1 +Polysaccharide biosynthetic process 0.3278635816083377 0.238780661016061 0.8112756667957568 1.0 1.0 15 Q8N6G5 1 +Response to progesterone 0.3959280216521095 0.2381989967702547 0.8117267551910992 1.0 1.0 6 P30536 1 +Regulation of presynaptic cytosolic calcium ion concentration 0.5645412005506202 0.235977904096439 0.813449816012962 1.0 1.0 3 P20020 1 +Calcium mediated signaling using intracellular calcium source 0.564509241803216 0.2359033541287804 0.8135076654813607 1.0 1.0 3 P51572 1 +Pentose metabolic process 0.4665091657489181 0.2329319618890473 0.8158142389838694 1.0 1.0 4 Q9UKK9 1 +Negative regulation of peptidyl tyrosine phosphorylation 0.3941900456577887 0.2316943015332063 0.8167754576832893 1.0 1.0 6 O95684 1 +Negative regulation of intracellular steroid hormone receptor signaling pathway 0.3549819639238132 0.2315923218518196 0.8168546716734266 1.0 1.0 10 P38398,Q99623 2 +Endosome to lysosome transport via multivesicular body sorting pathway 0.4659620764687702 0.2314197957460874 0.8169886877384702 1.0 1.0 4 Q9Y3E7,Q9UQN3,P55072 3 +Threonine catabolic process 0.5756446101273596 0.2268734377649282 0.8205221571135977 1.0 1.0 2 P52758 1 +Negative regulation of cell killing 0.4641649564551566 0.2264797020826869 0.820828344514108 1.0 1.0 4 P04439 1 +Microglial cell activation 0.5593485792289619 0.2240163567537017 0.8227445758014964 1.0 1.0 3 P05067 1 +Response to wounding 0.2809441917324011 0.2234420123701215 0.823191509584905 1.0 1.0 84 P50148,Q5JRA6,P09601,P38435,Q99623,O00203,P07196,P53582,P30536,O14656,P42785,P55011,Q4KMQ2,Q96G23,Q9UIJ7,Q9BWH2,Q04656,Q8WTV0 18 +Positive regulation of homotypic cell cell adhesion 0.5737806772289451 0.2229181651390213 0.8235991983524229 1.0 1.0 2 Q12955 1 +Positive regulation of endothelial cell development 0.5737806772289419 0.2229181651390145 0.8235991983524282 1.0 1.0 2 P35611 1 +External encapsulating structure organization 0.3069451773194159 0.222436690052234 0.8239739526140575 1.0 1.0 28 Q96AY3,P13674,Q92791,Q53GQ0,P05067,P39210,O75955,Q04656 8 +Regulation of nucleotide biosynthetic process 0.3687701771155801 0.2184937894988837 0.8270443966971499 1.0 1.0 8 P00403 1 +Positive regulation of immune effector process 0.3047848996721162 0.2184445009210665 0.8270827958973204 1.0 1.0 37 P11279,P09601,Q99623,Q9NQT5,P04439,O15400,O96028,P35232 8 +Regulation of proton transport 0.36874079225904 0.2183687237095168 0.8271418323757451 1.0 1.0 8 Q99623 1 +Response to potassium ion 0.4606211773647823 0.2168614318330201 0.8283163352560932 1.0 1.0 4 Q14168 1 +Cellular response to potassium ion 0.4606211773647823 0.2168614318330201 0.8283163352560932 1.0 1.0 4 Q14168 1 +Blastoderm segmentation 0.4021948360804169 0.2167656116749643 0.8283910126690488 1.0 1.0 5 Q8N2A8 1 +Wound healing 0.2635828459785838 0.2164037064996538 0.8286730773516982 1.0 1.0 64 P50148,Q5JRA6,P09601,P38435,O00203,O14656,P42785,P55011,Q4KMQ2,Q9UIJ7,Q9BWH2,P53582,Q8WTV0 13 +Glycerophospholipid catabolic process 0.3562253308285567 0.2153471677617651 0.8294966576088503 1.0 1.0 9 Q8N2K0,Q8WTV0 2 +Segmentation 0.3236219520569592 0.2139540977582112 0.8305828529424066 1.0 1.0 15 Q15363,Q8N2A8 2 +Regulation of protein tyrosine kinase activity 0.3512359467059997 0.2136832711567712 0.830794057725444 1.0 1.0 10 P05067,O95684 2 +Positive regulation of ubiquitin protein ligase activity 0.5534493474207691 0.2108001988241205 0.833043183390292 1.0 1.0 3 P63208,P53350 2 +Protein stabilization 0.2697910991698621 0.21051773769019 0.8332636091628536 1.0 1.0 74 Q86Y82,P11279,P46379,Q99623,P04637,Q5HYI8,Q9NQC3,Q969V5,O75955,P13473,P40855,Q9UBV2,P35232,O76024 14 +Mitochondrion distribution 0.3996876122343458 0.2085399963493406 0.8348073564670169 1.0 1.0 5 O75153 1 +Positive regulation of phosphatase activity 0.3992537313432771 0.2071261729077175 0.835911322265046 1.0 1.0 5 Q15257,Q13464,P42345,Q8IV63 4 +Histamine production involved in inflammatory response 0.550573163598888 0.204502300098257 0.8379609947574262 1.0 1.0 3 Q9UNH7 1 +Histamine transport 0.550573163598888 0.204502300098257 0.8379609947574262 1.0 1.0 3 Q9UNH7 1 +Histamine secretion 0.550573163598888 0.204502300098257 0.8379609947574262 1.0 1.0 3 Q9UNH7 1 +Protein maturation by protein folding 0.3979095878061408 0.2027644244128671 0.8393191654977854 1.0 1.0 5 O76024 1 +Nucleoside bisphosphate metabolic process 0.2929483029829168 0.2025000687168868 0.8395258046943019 1.0 1.0 48 Q8WVC6,P50897,Q8TB61,Q9HCL2,Q53GQ0,P04035,P09622,O43252,Q9UKU0,P16260,Q9NZ01 11 +Respiratory system process 0.3759403650415447 0.2024803846935972 0.8395411915682904 1.0 1.0 7 P10253 1 +Negative regulation of inflammatory response 0.3205841955379461 0.1964080484381332 0.844290797205832 1.0 1.0 15 P04062 1 +Sensory organ development 0.2734430432682538 0.1963401862713331 0.844343909367721 1.0 1.0 59 Q16706,Q8NF37,O95140,P42892,Q8NBN7,Q99471,P54802,Q99797,P20020,P39210,O43819,P08670,Q6KCM7,Q12959 14 +Regulation of mitotic cell cycle spindle assembly checkpoint 0.4513521914827545 0.1924934841024243 0.8473556714080221 1.0 1.0 4 O14777,P12270,P14635 3 +Positive regulation of proteolysis involved in cellular protein catabolic process 0.2997870937491093 0.1919355849533162 0.8477926628585544 1.0 1.0 40 Q96HY6,P53634,Q9H000,Q4ZIN3,P46379,O43765,P51572,P04062,P54725,Q9Y5A7 10 +Cell proliferation involved in kidney development 0.5582479030754817 0.1917048510674917 0.8479734058678565 1.0 1.0 2 O95747 1 +Negative regulation of kidney development 0.5582479030754817 0.1917048510674917 0.8479734058678565 1.0 1.0 2 O95747 1 +Metanephric mesenchymal cell differentiation 0.5582479030754817 0.1917048510674917 0.8479734058678565 1.0 1.0 2 O95747 1 +Mesenchymal cell differentiation involved in kidney development 0.5582479030754817 0.1917048510674917 0.8479734058678565 1.0 1.0 2 O95747 1 +Cell proliferation involved in metanephros development 0.5582479030754817 0.1917048510674917 0.8479734058678565 1.0 1.0 2 O95747 1 +Positive regulation of lymphocyte mediated immunity 0.3143868617397231 0.1914950921350798 0.8481377253018216 1.0 1.0 18 P11279,Q9NQT5,P04439,O15400,O96028 5 +Central nervous system neuron development 0.3363939102148081 0.1906309562522005 0.8488147353439368 1.0 1.0 12 O14949 1 +Action potential 0.3007954835593714 0.1897830620915373 0.8494791291683936 1.0 1.0 23 P04062,Q96PU5,P16615 3 +Peroxisome proliferator activated receptor signaling pathway 0.5570052811432034 0.1893433639558562 0.849823710438455 1.0 1.0 2 O43707 1 +Gliogenesis 0.2822365008063014 0.1873542576576137 0.851382884592391 1.0 1.0 54 Q15382,O43175,Q92542,P30536,Q96N66,Q9NQC3,P05067,P04062,Q96G23,P08670 10 +Positive regulation of ubiquitin protein transferase activity 0.3452033075040589 0.1853909065212332 0.8529224403402043 1.0 1.0 10 Q96GG9,Q9UNE7,Q9BTE7 3 +Aortic valve morphogenesis 0.4482437053155146 0.1845824917180046 0.853556519547169 1.0 1.0 4 O94813,Q9Y6N7,O75116 3 +Activation of innate immune response 0.3059353399653126 0.1840558311162483 0.853969656102679 1.0 1.0 21 Q9NUD5,Q8WXF1,P23246 3 +Regulation of potassium ion transmembrane transporter activity 0.3349340191205262 0.1832657779579249 0.8545894848394573 1.0 1.0 12 Q96PU5,Q12959 2 +Endothelial cell migration 0.3008666521283291 0.18280188376441 0.8549534704888355 1.0 1.0 36 P06576,Q5JRA6,P09601,P23634,Q99828,P57105,Q8WTV0 7 +Sulfur compound catabolic process 0.3444666567508272 0.1819842821973348 0.8555950609172882 1.0 1.0 10 Q9UJ14 1 +Positive regulation of organelle assembly 0.3013028838274706 0.1817266149675275 0.8557972780203829 1.0 1.0 27 Q9P2W9 1 +Negative regulation of lipid localization 0.4459239722625776 0.1787658699437521 0.8581215453768887 1.0 1.0 4 P31751 1 +Vesicle targeting 0.3076661587745805 0.1781166194388786 0.8586313903063565 1.0 1.0 20 P49755,Q9BVK6,O15498,Q15363 4 +Smooth muscle cell proliferation 0.3139492037445933 0.1767972097246742 0.8596676808470551 1.0 1.0 17 O95140,P35232,P09601 3 +Stress response to metal ion 0.5373406702910006 0.1767780686393142 0.8596827164182006 1.0 1.0 3 Q04656 1 +Response to reactive oxygen species 0.3007138018654135 0.1735768926593441 0.8621979933125583 1.0 1.0 31 Q99720,P39210,P09601,Q04656 4 +Toll like receptor 4 signaling pathway 0.4435163061766554 0.1728081226619977 0.8628022521426011 1.0 1.0 4 O75955 1 +Regulation of toll like receptor 4 signaling pathway 0.4435163061766554 0.1728081226619977 0.8628022521426011 1.0 1.0 4 O75955 1 +Modulation by host of viral genome replication 0.3577571149292449 0.1726872170121172 0.8628972921806941 1.0 1.0 8 P27105 1 +Golgi to plasma membrane transport 0.2985414226973681 0.1699321287747912 0.8650635134704121 1.0 1.0 24 P61026,P98194,Q567U6,Q9BZG1,Q8N2H4 5 +Renal tubule development 0.3569213048104586 0.1693013222246797 0.8655596360107376 1.0 1.0 8 Q04721,Q12959 2 +Stress granule disassembly 0.5335612181479317 0.1692414659069205 0.8656067151138116 1.0 1.0 3 Q07866,P33176 2 +Positive regulation of protein localization to cell periphery 0.3034710249597526 0.1675257606393903 0.8669563798774296 1.0 1.0 21 P98194,P23634,O00264,O15258,Q99828,Q12959 6 +Glucocorticoid metabolic process 0.4411949553537311 0.1671410912395763 0.8672590346124007 1.0 1.0 4 P05023 1 +Intrinsic apoptotic signaling pathway in response to dna damage 0.3003594817071076 0.1653110049808633 0.8686991972698583 1.0 1.0 22 P09601,P46379,P04637,Q9NX61,P38398,Q07820 6 +Leukocyte apoptotic process 0.3056477776258213 0.1649956162369645 0.8689474325038791 1.0 1.0 20 P24390 1 +Negative regulation of immune system process 0.2799898641631863 0.1649524220801612 0.868981430638557 1.0 1.0 54 P10644,Q5JRA6,Q9H000,P09601,P04439,Q9HCL2,Q86UT6,Q14166,Q969V5,Q08722,Q12959 11 +Spindle assembly involved in female meiosis 0.5433364398881527 0.1646985427728231 0.8691812640169019 1.0 1.0 2 O14777 1 +Cell growth 0.2922458888662502 0.163492681748205 0.8701305347471511 1.0 1.0 101 Q9P0J0,Q9BSK2,Q9NVI7,Q9NQC3,Q9GZP9,Q96PU5,P50897,Q9BTE7,P05067,O95684,Q5BJF2,P51812,Q969V5,Q15375,O14681,Q99828,Q9Y263,P04637,Q7Z4V5,P35232 20 +Male gamete generation 0.266798906746092 0.1634589818603296 0.8701570664667642 1.0 1.0 75 P41208,Q9GZT3,P46379,Q8N2A8,P04920,P23634,Q9Y2W6,P51572,P09622,Q08378,Q9BTX1,Q15645,O95470,Q99828,O00203 15 +Wnt protein secretion 0.5305317037902209 0.1633241469599459 0.8702632226370928 1.0 1.0 3 Q5T9L3 1 +Error free translesion synthesis 0.5417831624728139 0.162052396321004 0.8712645928269631 1.0 1.0 2 Q9Y2S7 1 +Positive regulation of oxidative stress induced cell death 0.4386995374358171 0.1611341980803616 0.8719877059924432 1.0 1.0 4 Q07820 1 +Neutrophil activation involved in immune response 0.4382965495803588 0.1601724486108781 0.8727452319882378 1.0 1.0 4 P51809,Q15833,P11274 3 +Neutrophil degranulation 0.4382965495803588 0.1601724486108781 0.8727452319882378 1.0 1.0 4 P51809,Q15833,P11274 3 +Response to xenobiotic stimulus 0.2611286457259741 0.1597188968526055 0.8731025144661768 1.0 1.0 63 P16435,P33121,Q08257,P09601,P28288,O15228,P04637,P30536,Q6PIU2,P50416,P07099,P05023,P40939,O43169,Q16836,O15118 16 +Regulation of short term neuronal synaptic plasticity 0.5386766076421176 0.156854407479264 0.8753595925352458 1.0 1.0 2 Q96A49 1 +Neurotransmitter uptake 0.3731538249125494 0.1567899766481229 0.8754103726232945 1.0 1.0 6 O75955 1 +Positive regulation of glucose import 0.3731140293703594 0.1566553504592632 0.8755164776706656 1.0 1.0 6 P31751,Q9UKG1 2 +Regulation of secretion 0.2839601384915399 0.1560569823764483 0.8759881059328243 1.0 1.0 93 Q4J6C6,Q8NE86,P55011,Q5T9L3,P40939,Q9Y5X3,Q16836,P16615,P61026,P09601,Q96KC8,P50416,Q16850,P11279,Q9BRT2,Q9UNH7,Q8N5M9,P49755,Q7L0J3,P04035 20 +Centriole centriole cohesion 0.4364314578800187 0.155751553342124 0.8762288592986787 1.0 1.0 4 Q14203,P35222,Q9Y496 3 +Tyrosine catabolic process 0.536191363777568 0.1527863885128234 0.8785667320952086 1.0 1.0 2 O43708 1 +Positive regulation of torc1 signaling 0.4345663661796818 0.1513805691931485 0.8796755163544494 1.0 1.0 4 Q9Y4R8,Q9NWS0,Q96EE3 3 +Regulation of membrane depolarization 0.3370114168369452 0.1481277825113491 0.8822419240295456 1.0 1.0 10 Q96PU5 1 +Prostanoid biosynthetic process 0.3614560348923637 0.1479999096972007 0.882342839508645 1.0 1.0 7 Q9H7Z7 1 +Establishment of lymphocyte polarity 0.4328843816954502 0.1474817156645039 0.8827518106993397 1.0 1.0 4 Q96L92 1 +Nls bearing protein import into nucleus 0.3367818252735577 0.1471035647757629 0.8830502762067609 1.0 1.0 10 Q8NFH5,P52292 2 +Adiponectin activated signaling pathway 0.5212994360137877 0.1459752445869005 0.8839409310259037 1.0 1.0 3 P33121 1 +Regulation of clathrin dependent endocytosis 0.5318421870145864 0.1458600516901668 0.8840318683709001 1.0 1.0 2 P50570 1 +Regulation of protein complex stability 0.4315825776644555 0.144492236166771 0.8851117867608811 1.0 1.0 4 Q969V3 1 +Regulation of homotypic cell cell adhesion 0.4314578800124451 0.144207169532177 0.8853368796560053 1.0 1.0 4 Q12955,Q9Y624,P35241 3 +Tolerance induction 0.4314578800124407 0.1442071695321669 0.8853368796560133 1.0 1.0 4 P01889,Q96J02,P09429 3 +Regulation of epithelial cell differentiation involved in kidney development 0.5201988812927409 0.1439760910289506 0.8855193495034359 1.0 1.0 3 O95747,P42224 2 +Negative regulation of epithelial cell differentiation 0.5201988812927409 0.1439760910289506 0.8855193495034359 1.0 1.0 3 O95747,P42224 2 +Renal vesicle development 0.5201988812927409 0.1439760910289506 0.8855193495034359 1.0 1.0 3 O95747,P42224 2 +Nephron tubule epithelial cell differentiation 0.5201988812927409 0.1439760910289506 0.8855193495034359 1.0 1.0 3 O95747,P42224 2 +Golgi to endosome transport 0.3395217397726288 0.1417309482763648 0.887292528508441 1.0 1.0 9 Q8N2H4 1 +Protein localization to phagophore assembly site 0.3778192860132196 0.140996183231014 0.8878729575624587 1.0 1.0 5 Q7Z3C6 1 +Negative regulation of cell development 0.2938876055328671 0.1409081140559171 0.8879425320178171 1.0 1.0 23 Q9NQC3,P04637,Q96G23 3 +Neutrophil chemotaxis 0.3210574333218446 0.1385829959548236 0.8897796809018814 1.0 1.0 13 Q8NHP6,Q8NE86,P78310,P35613 4 +Ventral spinal cord development 0.4283493938452063 0.1371741535260286 0.8908931402627083 1.0 1.0 4 Q14203,Q8NCM8,Q6Y7W6 3 +Defense response to symbiont 0.2590078173388299 0.1356930107870104 0.8920639731994682 1.0 1.0 63 O75844,Q9NVI7,Q99623,Q9HCL2,O60858,Q969V5,O43657 7 +Response to monosaccharide 0.2956140790294093 0.1350059986536491 0.8926071315164577 1.0 1.0 32 Q9HCL2,Q8N5M9 2 +Central nervous system neuron differentiation 0.3066830867872392 0.1339285811432857 0.893459049395749 1.0 1.0 17 O14949 1 +Protein mannosylation 0.5142945929148685 0.133502620966065 0.8937958915953157 1.0 1.0 3 Q6ZXV5,O43505 2 +Protein o linked mannosylation 0.5142945929148685 0.133502620966065 0.8937958915953157 1.0 1.0 3 Q6ZXV5,O43505 2 +Ether metabolic process 0.337427925780602 0.13290052889556 0.8942720486170321 1.0 1.0 9 O15228,Q6IAN0,Q6PIU2,O00116,P07099,P49327 6 +Negative regulation of nitric oxide synthase activity 0.5139140768272904 0.1328421967522361 0.8943181818939931 1.0 1.0 3 P06280 1 +Negative regulation of monooxygenase activity 0.5139140768272904 0.1328421967522361 0.8943181818939931 1.0 1.0 3 P06280 1 +Positive regulation of protein export from nucleus 0.3333676949122951 0.1320076588161081 0.8949782339072463 1.0 1.0 10 P50402 1 +Positive regulation of synaptic transmission 0.3042318747926202 0.1296281284666583 0.8968606477098757 1.0 1.0 18 Q14168,Q92542,P05067 3 +Organ induction 0.5200372786579581 0.128286210879479 0.8979224770614231 1.0 1.0 2 Q9Y6N7 1 +Developmental induction 0.5200372786579581 0.128286210879479 0.8979224770614231 1.0 1.0 2 Q9Y6N7 1 +Regulation of animal organ formation 0.5200372786579581 0.128286210879479 0.8979224770614231 1.0 1.0 2 Q9Y6N7 1 +Positive regulation of animal organ morphogenesis 0.5200372786579581 0.128286210879479 0.8979224770614231 1.0 1.0 2 Q9Y6N7 1 +Regulation of core promoter binding 0.5200372786579567 0.1282862108794771 0.8979224770614247 1.0 1.0 2 Q12948 1 +Mesenchymal to epithelial transition involved in metanephros morphogenesis 0.5200372786579563 0.1282862108794768 0.8979224770614249 1.0 1.0 2 P42224 1 +Positive regulation of mesenchymal cell proliferation 0.5200372786579563 0.1282862108794768 0.8979224770614249 1.0 1.0 2 P42224 1 +Metanephric nephron morphogenesis 0.5200372786579563 0.1282862108794768 0.8979224770614249 1.0 1.0 2 P42224 1 +Regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis 0.5200372786579563 0.1282862108794768 0.8979224770614249 1.0 1.0 2 P42224 1 +Metanephric renal vesicle morphogenesis 0.5200372786579563 0.1282862108794768 0.8979224770614249 1.0 1.0 2 P42224 1 +Limb joint morphogenesis 0.5200372786579532 0.1282862108794723 0.8979224770614285 1.0 1.0 2 O95747 1 +Embryonic skeletal joint morphogenesis 0.5200372786579532 0.1282862108794723 0.8979224770614285 1.0 1.0 2 O95747 1 +Nephron tubule formation 0.5200372786579532 0.1282862108794723 0.8979224770614285 1.0 1.0 2 O95747 1 +Embryonic skeletal joint development 0.5200372786579532 0.1282862108794723 0.8979224770614285 1.0 1.0 2 O95747 1 +Embryonic hindlimb morphogenesis 0.5200372786579532 0.1282862108794723 0.8979224770614285 1.0 1.0 2 O95747 1 +Hindlimb morphogenesis 0.5200372786579532 0.1282862108794723 0.8979224770614285 1.0 1.0 2 O95747 1 +Lung associated mesenchyme development 0.5200372786579532 0.1282862108794723 0.8979224770614285 1.0 1.0 2 Q13308 1 +Molting cycle 0.313558735257855 0.1265143567643778 0.8993247853037891 1.0 1.0 14 O75844 1 +Regulation of ion transmembrane transport 0.2687920358114323 0.1254961784292141 0.9001307502937357 1.0 1.0 58 O75844,Q96PU5,P0CG08,Q99623,O75323,P23634,O75915,P05067,P21796,Q4KMQ2,P27105,Q15041,P54709,Q04656,Q12959 15 +Regulation of mitochondrial membrane potential 0.2970680206591524 0.12530765243796 0.900279994167962 1.0 1.0 21 Q9BSK2,Q8IWA4,Q969V5,P30536 4 +Regulation of smoothened signaling pathway 0.3230934661876046 0.1252396490357806 0.9003338289432599 1.0 1.0 12 P16435,Q96J42 2 +Plasma membrane to endosome transport 0.4227541187441755 0.1248715537298736 0.9006252389047642 1.0 1.0 4 P61020,Q99523,Q15286 3 +Membrane raft assembly 0.3713547149714402 0.1225544644511369 0.9024599146302128 1.0 1.0 5 Q14254,O75955 2 +Positive regulation of calcium ion transport 0.3073577828568962 0.1225225240927322 0.902485208730288 1.0 1.0 15 P20020,O75323,P30536,O76024 4 +Alpha beta t cell differentiation 0.3270229247192813 0.1223949318428681 0.9025862521384188 1.0 1.0 11 Q04656 1 +Positive regulation of intracellular transport 0.2589495771275134 0.1195038667353047 0.9048761767793896 1.0 1.0 71 Q9Y282,P50402,P51572,Q9NR31,Q9Y371,P55786,Q9Y3D6,Q9P2W9,Q9C0E2,P27105,P31751,O14737,Q99828 13 +Canonical wnt signaling pathway involved in osteoblast differentiation 0.5135135135134982 0.119333062596151 0.9050114904780052 1.0 1.0 2 P35222 1 +Mesenchymal stem cell differentiation 0.5135135135134982 0.119333062596151 0.9050114904780052 1.0 1.0 2 P35222 1 +Response to caffeine 0.5122708915812351 0.1176880655135262 0.9063148234003952 1.0 1.0 2 Q13131 1 +Male mating behavior 0.5122708915812249 0.1176880655135124 0.906314823400406 1.0 1.0 2 P07686 1 +Negative regulation of dendritic spine development 0.5122708915812189 0.1176880655135049 0.906314823400412 1.0 1.0 2 Q05086 1 +Somitogenesis 0.3336652125896098 0.1172698578407052 0.9066462101499746 1.0 1.0 9 Q15363 1 +Negative regulation of signaling receptor activity 0.4190239353434997 0.1169267222608716 0.9069181220952552 1.0 1.0 4 P30533,Q9UNH7,Q86XI2 3 +Negative regulation of protein serine threonine kinase activity 0.3036132319318179 0.1162262626143264 0.9074732232430208 1.0 1.0 17 P04062,P04035 2 +Positive regulation of sodium ion transmembrane transport 0.360020490222078 0.1139206067389537 0.9093007300944485 1.0 1.0 6 P54709,P50570 2 +Second messenger mediated signaling 0.2915755182853634 0.1138909112055696 0.909324270492935 1.0 1.0 26 O75844,Q8NE86,P51572,P23634,Q99828,P16615 6 +Glomerulus development 0.3516991127247443 0.1135047099476371 0.9096304292166276 1.0 1.0 7 P39210 1 +Regulation of sulfur metabolic process 0.5015537600994558 0.1123489556247381 0.9105467265033368 1.0 1.0 3 Q15120,O75027 2 +Negative regulation of transporter activity 0.32019393829263 0.1115226227860613 0.9112019271067896 1.0 1.0 12 Q96PU5 1 +Apoptotic cell clearance 0.3319286624947941 0.1101614967779214 0.9122812974918588 1.0 1.0 9 Q8WTV0 1 +Positive regulation of myotube differentiation 0.5048151599875575 0.1082182282420448 0.9138225858248112 1.0 1.0 2 P42345 1 +Regulation of dna helicase activity 0.4981354878806863 0.1070095394713239 0.9147814118096728 1.0 1.0 3 Q04837,P33993 2 +Positive regulation of inflammatory response 0.3146601491771815 0.1068375669551061 0.914917843901851 1.0 1.0 13 P05067,Q08722 2 +Epithelial cell apoptotic process 0.3145650906004307 0.1063735709059437 0.9152859614466116 1.0 1.0 13 P09601 1 +Negative regulation of organ growth 0.4137427291840276 0.1060325940563408 0.9155564916312716 1.0 1.0 4 P11413 1 +Astrocyte development 0.340597572804826 0.1059431883572955 0.9156274275104156 1.0 1.0 8 P08670,P05067 2 +Regulation of neuron projection development 0.2556836106676662 0.1053964248493012 0.9160612528224568 1.0 1.0 69 Q96PU5,Q8WWV3,Q9NQC3,Q96G23,Q9NQX7,Q14108 6 +Regulation of acyl coa biosynthetic process 0.5013979496737999 0.1041043350495182 0.9170865506818722 1.0 1.0 2 Q15120 1 +Hypoxia inducible factor 1alpha signaling pathway 0.5013979496737999 0.1041043350495182 0.9170865506818722 1.0 1.0 2 Q15120 1 +Synaptic transmission gabaergic 0.3645737235129934 0.1039990700472618 0.9171700865643776 1.0 1.0 5 P51790 1 +Regulation of leukocyte mediated immunity 0.2914118802076006 0.1037003739061595 0.9174071299218832 1.0 1.0 33 P11279,P09601,Q9NQT5,P04439,O15400,O96028,Q9NUQ9 7 +Negative regulation of protein kinase b signaling 0.3486759899540935 0.1031993187019651 0.9178047806230524 1.0 1.0 7 Q99828,Q969V5 2 +Negative regulation of lipid transport 0.4956180547760508 0.1031678015547859 0.9178297941555018 1.0 1.0 3 P31751 1 +Farnesyl diphosphate metabolic process 0.4955304112317095 0.1030354338225849 0.9179348484780688 1.0 1.0 3 P37268 1 +Establishment of planar polarity involved in neural tube closure 0.4995340167753792 0.1019195480383393 0.918820533668372 1.0 1.0 2 Q13308 1 +Cellular response to xenobiotic stimulus 0.293334401866305 0.1012130086691555 0.9193813703242566 1.0 1.0 21 P16435,Q08257,P04637,Q6PIU2,P07099,O43169 6 +Deadenylation dependent decapping of nuclear transcribed mrna 0.4937849596022463 0.1004186085690179 0.92001199693574 1.0 1.0 3 Q8IZD4,Q86TB9 2 +Glutathione metabolic process 0.2954208409097535 0.1001560150631907 0.9202204652590932 1.0 1.0 20 Q8TB36,Q9UJ14,Q9H7Z7,O75915,Q99735 5 +Negative regulation of leukocyte proliferation 0.3389391019422118 0.0998155159720259 0.9204907896058684 1.0 1.0 8 P10644 1 +Regulation of cytosolic calcium ion concentration 0.2950819668177737 0.0980576740071108 0.9218864967432532 1.0 1.0 20 Q96HE7,P51572,P23634,P20020,O95202 5 +Intrinsic apoptotic signaling pathway in response to oxidative stress 0.3172253089353937 0.0976920849511234 0.9221768007870256 1.0 1.0 12 P23246,P07237,Q15233,Q07820,O75915 5 +Tyrosine metabolic process 0.4906774394033652 0.0958506429584281 0.92363919522057 1.0 1.0 3 O43708,P16930 2 +Negative regulation of receptor signaling pathway via jak stat 0.4920782851817339 0.0935914493074472 0.9254337022634944 1.0 1.0 2 O14964 1 +Negative regulation of receptor signaling pathway via stat 0.4920782851817339 0.0935914493074472 0.9254337022634944 1.0 1.0 2 O14964 1 +Torc1 signaling 0.3456751711263217 0.0931548278823296 0.925780560405444 1.0 1.0 7 Q9NWS0,P42345,Q96EE3,Q8N122,Q9Y4R8,Q9P2J5 6 +Visual behavior 0.3527117506237887 0.0914711290341777 0.9271182457369648 1.0 1.0 6 P04035 1 +Response to gamma radiation 0.3013976732455603 0.0906990008655679 0.9277317645544032 1.0 1.0 15 O75844 1 +Keratinization 0.4892823858340924 0.0906352437208221 0.9277824267323884 1.0 1.0 2 Q8NEY8 1 +Muscle cell apoptotic process 0.3194698018256732 0.0887953594634176 0.9292445457359936 1.0 1.0 11 P04637,P09601 2 +Negative regulation of interferon gamma production 0.4855545200372608 0.0868323568831598 0.9308047676768656 1.0 1.0 2 P09429 1 +Positive regulation of phagocytosis 0.3348497051401774 0.0849629668884584 0.9322908323548984 1.0 1.0 8 Q08722,Q4KMQ2,P50570 3 +Endoplasmic reticulum plasma membrane tethering 0.4822871348663873 0.0840951154623927 0.932980808185372 1.0 1.0 3 O95292,A0FGR8 2 +Endoplasmic reticulum localization 0.4822871348663873 0.0840951154623927 0.932980808185372 1.0 1.0 3 O95292,A0FGR8 2 +Regulation of striated muscle cell differentiation 0.3253721067449666 0.0839431752003873 0.9331016118315314 1.0 1.0 9 Q96TA1 1 +Response to catecholamine 0.3051125741327204 0.0834910390850433 0.9334611022902988 1.0 1.0 14 P05067,Q92542 2 +Glucose catabolic process 0.3182087894819043 0.0833216474422884 0.9335957879724924 1.0 1.0 11 P04637,P52789 2 +Negative regulation of intracellular signal transduction 0.2861097171419292 0.0832027655786636 0.933690313752974 1.0 1.0 102 Q9P0J0,O60313,Q9NX61,Q07820,Q10713,O43657,Q96P70,Q12959,P45880,P23634,Q86UT6,P57105,O76024,Q9NUQ9,O14578,P04062,Q969V5,Q99828,Q9H000,O95140,Q15233,P04035,P35232,Q96FV9 24 +Dna strand elongation involved in dna replication 0.3137352299425395 0.0817168552428234 0.9348718746412248 1.0 1.0 12 P49916,P33991 2 +Regulation of lymphocyte mediated immunity 0.2877920985639823 0.0811709935861491 0.9353059671417304 1.0 1.0 22 P11279,Q9NQT5,P04439,O15400,O96028,Q9NUQ9 6 +Hepatic stellate cell activation 0.479652065858944 0.0811290572417457 0.935339317510942 1.0 1.0 2 P48506 1 +Fibroblast activation 0.479652065858944 0.0811290572417457 0.935339317510942 1.0 1.0 2 P48506 1 +Regulation of hepatic stellate cell activation 0.479652065858944 0.0811290572417457 0.935339317510942 1.0 1.0 2 P48506 1 +Notch signaling involved in heart development 0.4790307548928116 0.0805509959998426 0.9357990390224944 1.0 1.0 2 Q04721 1 +Myeloid dendritic cell differentiation 0.4790307548928116 0.0805509959998426 0.9357990390224944 1.0 1.0 2 Q04721 1 +Endocardial cushion morphogenesis 0.4790307548928054 0.0805509959998368 0.9357990390224992 1.0 1.0 2 Q9Y6N7 1 +Heart field specification 0.4790307548928054 0.0805509959998368 0.9357990390224992 1.0 1.0 2 Q9Y6N7 1 +Endocardial cushion development 0.4790307548928054 0.0805509959998368 0.9357990390224992 1.0 1.0 2 Q9Y6N7 1 +Endocardial cushion formation 0.4790307548928054 0.0805509959998368 0.9357990390224992 1.0 1.0 2 Q9Y6N7 1 +Regulation of stress granule assembly 0.4003730183400761 0.0803238518815857 0.9359796884437396 1.0 1.0 4 P54646,Q13131,Q9UN86 3 +Myeloid dendritic cell activation 0.4791796146675113 0.0799535497532762 0.9362741995667236 1.0 1.0 3 P09429,Q04721 2 +Regulation of cardiac muscle cell proliferation 0.4791796146675103 0.0799535497532751 0.9362741995667244 1.0 1.0 3 Q16539,P06493 2 +Positive regulation of cardiac muscle cell proliferation 0.4791796146675103 0.0799535497532751 0.9362741995667244 1.0 1.0 3 Q16539,P06493 2 +Cell surface receptor signaling pathway involved in heart development 0.4791796146675099 0.079953549753274 0.9362741995667254 1.0 1.0 3 P35222,Q04721 2 +Specification of animal organ identity 0.4791796146675095 0.0799535497532737 0.9362741995667256 1.0 1.0 3 P35222,Q9Y6N7 2 +Heart formation 0.4791796146675095 0.0799535497532737 0.9362741995667256 1.0 1.0 3 P35222,Q9Y6N7 2 +Fucose metabolic process 0.4780285059046982 0.0784482968019684 0.9374714565804882 1.0 1.0 3 Q9BTY2 1 +Negative regulation of guanyl nucleotide exchange factor activity 0.4765455110282512 0.0782805326078811 0.937604902665976 1.0 1.0 2 P16949 1 +Positive regulation of phosphoprotein phosphatase activity 0.3991296238731754 0.0780697440415643 0.9377725744739968 1.0 1.0 4 Q15257,P42345,Q8IV63 3 +Regulation of guanyl nucleotide exchange factor activity 0.4766935985083982 0.0767221791196512 0.9388445601567064 1.0 1.0 3 Q9Y2S7,P16949 2 +Negative regulation of vascular permeability 0.4743709226467821 0.0763481863676622 0.9391420905083104 1.0 1.0 2 O94813 1 +Positive regulation of integrin activation 0.4743709226467659 0.076348186367648 0.939142090508322 1.0 1.0 2 P12931 1 +Interleukin 1 mediated signaling pathway 0.4703324013668802 0.0728918169754955 0.9418922057299246 1.0 1.0 2 O14920 1 +Positive regulation of intrinsic apoptotic signaling pathway 0.302744343605939 0.0717765110771787 0.9427797660405616 1.0 1.0 14 Q07820,P04637,P51572,P23246 4 +Regulation of mitotic centrosome separation 0.4653619136377673 0.068868664289285 0.9450941615524756 1.0 1.0 2 P52732 1 +Small gtpase mediated signal transduction 0.2753168136262919 0.0688244475070686 0.9451293579286713 1.0 1.0 92 Q8IXI1,Q7Z569,Q15382,P09601,Q96RU2,Q15392,O95140,P04637,Q9P035,Q02818,Q96AG4,Q5HYI8,O75955,P80303,O75962,P57105,Q9NUQ9 17 +Regulation of immune effector process 0.2792733038028089 0.0687015440189591 0.9452271891604882 1.0 1.0 47 P11279,P09601,Q99623,Q9NQT5,P04439,O15400,O96028,Q08722,P35232,Q9NUQ9 10 +Free ubiquitin chain polymerization 0.4638086362224164 0.0676625227493482 0.9460542834230552 1.0 1.0 2 Q16763 1 +Response to fatty acid 0.3059551162821888 0.0653345164600463 0.947907660880783 1.0 1.0 13 O00767,P50416,O15228 3 +Ensheathment of neurons 0.2850148286398193 0.0651170358584552 0.9480808165657496 1.0 1.0 27 Q13144,Q9NR77,O75746,Q92542,Q16880,P31751,O15228,Q12959 8 +Response to oxygen radical 0.391489228638738 0.0647299988415889 0.9483889772807588 1.0 1.0 4 Q04656 1 +Cellular response to oxygen radical 0.391489228638738 0.0647299988415889 0.9483889772807588 1.0 1.0 4 Q04656 1 +Ear development 0.2851684241070249 0.0642030562047862 0.9488085439183344 1.0 1.0 22 P42892,P54802 2 +Negative regulation of nuclear transcribed mrna catabolic process nonsense mediated decay 0.4664387818520913 0.064152432843348 0.9488488524203188 1.0 1.0 3 Q99729,A2RRP1 2 +Regulation of endodeoxyribonuclease activity 0.4661280298322098 0.0637903982929116 0.9491371237407192 1.0 1.0 3 P09429,P06748 2 +Negative regulation of gliogenesis 0.3429555520901335 0.0631505313502129 0.9496466363665176 1.0 1.0 6 Q96G23 1 +Membrane depolarization during cardiac muscle cell action potential 0.4575955265610238 0.0630744908409225 0.9497071872019832 1.0 1.0 2 Q12955 1 +Regulation of membrane depolarization during action potential 0.4575955265610238 0.0630744908409225 0.9497071872019832 1.0 1.0 2 Q12955 1 +Regulation of membrane depolarization during cardiac muscle cell action potential 0.4575955265610238 0.0630744908409225 0.9497071872019832 1.0 1.0 2 Q12955 1 +Keratinocyte proliferation 0.3482587064676514 0.0627818877867047 0.9499401888652514 1.0 1.0 5 Q6ZWJ1,Q04721,Q9Y3B8,O14936 4 +Regulation of keratinocyte proliferation 0.3482587064676514 0.0627818877867047 0.9499401888652514 1.0 1.0 5 Q6ZWJ1,Q04721,Q9Y3B8,O14936 4 +Postsynaptic signal transduction 0.3478446868061901 0.0618003430367972 0.9507218303076984 1.0 1.0 5 P50148,P52292 2 +Positive regulation of type i interferon mediated signaling pathway 0.4639527656929934 0.0612868397455678 0.9511307714618624 1.0 1.0 3 Q9NZI8,Q7Z434 2 +Positive regulation of cell cycle checkpoint 0.3888716195212951 0.0603616702691873 0.9518675856603728 1.0 1.0 4 O14777,P12270,Q9Y6G9 3 +Skeletal muscle cell differentiation 0.3347219947762793 0.0581037243188676 0.953666007829762 1.0 1.0 7 P50402 1 +Positive regulation of nervous system process 0.3867950817128293 0.0569693510300238 0.9545696098102144 1.0 1.0 4 P04062 1 +Regulation of endocytosis 0.2788892914078997 0.0567792634794068 0.9547210326309704 1.0 1.0 46 Q96PU5,P50897,P05067,O75955,Q6UWE0,P57105 6 +Leukocyte adhesion to vascular endothelial cell 0.4479652065858936 0.0566807287580348 0.9547995255555536 1.0 1.0 2 P05556 1 +Leukocyte tethering or rolling 0.4479652065858936 0.0566807287580348 0.9547995255555536 1.0 1.0 2 P05556 1 +Negative regulation of leukocyte cell cell adhesion 0.3078540960022243 0.055520250261226 0.9557239974552724 1.0 1.0 12 P10644,Q5JRA6 2 +Regulation of lymphocyte differentiation 0.2945084599198416 0.0551783266667271 0.9559963954396729 1.0 1.0 15 O96005,O00203 2 +Unsaturated fatty acid biosynthetic process 0.317792863002984 0.0549070685581602 0.956212500481182 1.0 1.0 9 Q8NCG7,Q9H7Z7,O00767 3 +Membrane depolarization during action potential 0.457737725295225 0.0544268459266365 0.9565950905929016 1.0 1.0 3 Q12955,Q04917 2 +T cell migration 0.3260866667285202 0.0544046823229535 0.9566127484276392 1.0 1.0 8 P05067 1 +Oocyte construction 0.4575789554432267 0.0542572301839686 0.9567302246983408 1.0 1.0 3 Q8N2A8 1 +Muscle cell proliferation 0.2817116158446657 0.0535642863422616 0.957282311013385 1.0 1.0 24 O95140,P10644,P09601,P35232 4 +Regulation of system process 0.2578809844092586 0.0529244648280412 0.9577920915955068 1.0 1.0 60 O75844,P02545,P42892,O75746,P04899,P78310,P23634,P10253,P05067,P20020,P04062,P05023,P11413,Q9Y5X3,P16615,Q12959 16 +Folic acid containing compound catabolic process 0.455251709136124 0.0518028480083919 0.9586857862178852 1.0 1.0 3 Q9NRN7,Q8IYS1 2 +Negative regulation of hematopoietic progenitor cell differentiation 0.4395775085430246 0.0517798376140478 0.9587041212493492 1.0 1.0 2 Q92785 1 +Negative regulation of glucose transmembrane transport 0.4380242311276779 0.0509368679276771 0.9593758272701456 1.0 1.0 2 P05771 1 +Positive regulation of protein k63 linked ubiquitination 0.4374029201615237 0.050605158827981 0.9596401519443264 1.0 1.0 2 P61088 1 +Positive regulation of chemokine c c motif ligand 5 production 0.4374029201615216 0.0506051588279801 0.9596401519443272 1.0 1.0 2 Q7Z434 1 +Mesonephros development 0.3246187363834341 0.0494597125785525 0.9605529425877336 1.0 1.0 8 Q12948,O95747,P35222,O94813,Q13418,P78540,Q12959 7 +Positive regulation of glucose transmembrane transport 0.3313069668620954 0.0477077019918927 0.9619491957923564 1.0 1.0 7 P31751,Q9UKG1 2 +Bleb assembly 0.3809090231361401 0.0477034712935734 0.9619525675622672 1.0 1.0 4 Q9NR77 1 +Positive regulation of mitotic cell cycle spindle assembly checkpoint 0.4512119328775787 0.0476827355410705 0.9619690934931472 1.0 1.0 3 O14777,P12270 2 +Positive regulation of oxidative stress induced intrinsic apoptotic signaling pathway 0.4510490254401493 0.0475202912538002 0.9620985585210204 1.0 1.0 3 Q07820 1 +Regulation of b cell receptor signaling pathway 0.431189810500154 0.0474558839007198 0.9621498902414378 1.0 1.0 2 P05771 1 +Regulation of platelet aggregation 0.4311898105001333 0.0474558839007098 0.9621498902414458 1.0 1.0 2 Q9Y624 1 +Positive regulation of t cell cytokine production 0.4502796768179147 0.0467569817270792 0.9627069151174354 1.0 1.0 3 P04439,Q12933 2 +T cell cytokine production 0.4502796768179147 0.0467569817270792 0.9627069151174354 1.0 1.0 3 P04439,Q12933 2 +Activation of nf kappab inducing kinase activity 0.4502796768179113 0.0467569817270759 0.962706915117438 1.0 1.0 3 Q99627,Q12933 2 +Insulin receptor signaling pathway 0.2829683022753324 0.0459456307846317 0.96335358445055 1.0 1.0 29 P18031,P43490,Q8TBX8,P04899,Q15043,Q6ZWJ1,P05771,O00459,P31751,Q9HCD5,P14735,Q9Y5X3,Q9UKG1 13 +Regulation of smooth muscle cell chemotaxis 0.427461944703322 0.0457079542404629 0.9635430238703068 1.0 1.0 2 O94813 1 +Smooth muscle cell chemotaxis 0.427461944703322 0.0457079542404629 0.9635430238703068 1.0 1.0 2 O94813 1 +Regulation of membrane protein ectodomain proteolysis 0.4481044126786981 0.044633036181061 0.9643998098250725 1.0 1.0 3 O43847,Q9Y5X1 2 +Negative regulation of bicellular tight junction assembly 0.4481044126786969 0.0446330361810596 0.9643998098250736 1.0 1.0 3 O14920,O75116 2 +Regulation of myosin light chain phosphatase activity 0.4481044126786969 0.0446330361810596 0.9643998098250736 1.0 1.0 3 O14920,O75116 2 +Negative regulation of myosin light chain phosphatase activity 0.4481044126786969 0.0446330361810596 0.9643998098250736 1.0 1.0 3 O14920,O75116 2 +Arf protein signal transduction 0.4476928463092507 0.044236842947146 0.964715614361177 1.0 1.0 3 Q15555 1 +Cellular glucose homeostasis 0.2822884403993747 0.0412260474573781 0.9671156884525818 1.0 1.0 29 Q8N5M9,Q15043 2 +Regulation of adherens junction organization 0.4443753884400416 0.041108518640871 0.9672093834524452 1.0 1.0 3 P35611,Q9H3S7 2 +Anterograde neuronal dense core vesicle transport 0.4162783473128324 0.0410580576834584 0.9672496115077632 1.0 1.0 2 P33176 1 +Dense core granule transport 0.4162783473128324 0.0410580576834584 0.9672496115077632 1.0 1.0 2 P33176 1 +Negative regulation of peptidase activity 0.2819806877928377 0.0399591401247119 0.9681257017138574 1.0 1.0 38 P16435,Q15392,P49755,P05067,Q04323,Q15041 6 +Negative regulation of protein acetylation 0.311005098787773 0.0398717966376265 0.96819533623915 1.0 1.0 10 P38398,Q01105 2 +Negative regulation of cyclin dependent protein serine threonine kinase activity 0.3379975124378034 0.0394118693018529 0.9685620169282512 1.0 1.0 5 Q96SZ6,P53350,O95373,O00410 4 +Erbb2 signaling pathway 0.3748834317687311 0.0387498639358438 0.9690898175667017 1.0 1.0 4 Q93034,Q9UNE7,P12931 3 +Regulation of protein monoubiquitination 0.4097545821683748 0.0387265959817686 0.96910836878335 1.0 1.0 2 O75340 1 +Positive regulation of protein monoubiquitination 0.4097545821683748 0.0387265959817686 0.96910836878335 1.0 1.0 2 O75340 1 +Negative regulation of macrophage chemotaxis 0.4041627834731285 0.0369324636806634 0.9705388551230087 1.0 1.0 2 P14174 1 +Negative regulation of macrophage migration 0.4041627834731285 0.0369324636806634 0.9705388551230087 1.0 1.0 2 P14174 1 +Bone remodeling 0.3100886960784765 0.0363640185739641 0.9709921042110152 1.0 1.0 10 Q9UBB6,O14773,Q92791 3 +Interferon beta production 0.2994662269091139 0.0357617727988784 0.9714723144434688 1.0 1.0 13 Q86UT6 1 +Error prone translesion synthesis 0.3998136067101575 0.035658898708808 0.971554343771877 1.0 1.0 2 P56282 1 +Regulation of response to interferon gamma 0.3988816402609458 0.0353992376318525 0.9717613926139944 1.0 1.0 2 Q16543 1 +Chemical synaptic transmission postsynaptic 0.3060679558599603 0.0327315473169202 0.9738886662423394 1.0 1.0 11 Q14168 1 +Regulation of postsynaptic membrane potential 0.3060679558599603 0.0327315473169202 0.9738886662423394 1.0 1.0 11 Q14168 1 +Synaptic vesicle exocytosis 0.2892839530576037 0.0323995269297323 0.9741534397466712 1.0 1.0 16 P16615 1 +Linoleic acid metabolic process 0.3858341099720415 0.0322166561870669 0.974299273357305 1.0 1.0 2 O95864 1 +Negative regulation of cell junction assembly 0.3089380255372185 0.0319911530396634 0.9744791061394772 1.0 1.0 10 O14920,Q9H6U6,P12931,O75122,Q9P258,P63167,Q13464,Q15375,O75116 9 +Cell cell adhesion mediated by integrin 0.3836595215905516 0.031762431212205 0.9746615070588702 1.0 1.0 2 P05556 1 +Motor neuron apoptotic process 0.3827275551413518 0.031573921450372 0.9748118406854748 1.0 1.0 2 P49327 1 +Synaptic transmission dopaminergic 0.3309526658597375 0.0309885665665837 0.9752786578532112 1.0 1.0 6 O75955 1 +Regulation of anion channel activity 0.3718546132339266 0.0296290640454112 0.9763628857283544 1.0 1.0 2 P08183 1 +Regulation of translation in response to stress 0.3052865918911109 0.029611495642327 0.9763768971380526 1.0 1.0 11 Q15363 1 +Medium chain fatty acyl coa metabolic process 0.3675054364709578 0.0289716557335853 0.9768871965494272 1.0 1.0 2 P51659 1 +Columnar cuboidal epithelial cell maturation 0.3662628145386727 0.0287953722399502 0.9770277917686084 1.0 1.0 2 Q86UL3 1 +Meiotic cell cycle phase transition 0.3656415035725353 0.0287090882632425 0.9770966079707084 1.0 1.0 2 O14777 1 +Regulation of epithelial cell migration 0.2784731040360504 0.0274853469498134 0.9780726268733502 1.0 1.0 42 Q9NQC3,P57105,P09601 3 +Cell differentiation in spinal cord 0.4282162834058603 0.027475798442066 0.9780802426040868 1.0 1.0 3 Q6Y7W6,Q8NCM8 2 +Spinal cord motor neuron differentiation 0.4282162834058603 0.027475798442066 0.9780802426040868 1.0 1.0 3 Q6Y7W6,Q8NCM8 2 +Glucose 6 phosphate metabolic process 0.3044905767071411 0.0264504029741598 0.9788980924347774 1.0 1.0 11 P04637,P52789 2 +Intrinsic apoptotic signaling pathway 0.2537602864631414 0.0260508361753534 0.9792167907867912 1.0 1.0 74 Q9P0J0,O60313,P46379,Q96HE7,Q96RU2,Q9NX61,Q9Y3D6,Q07820,P09601,Q8N2F6,P23246,P45880,Q13616,O76024,O95831,P04637,P51572,Q15233,P38398,O75915 20 +Regulation of microvillus length 0.3392357875116443 0.0260142055940835 0.97924600786027 1.0 1.0 2 Q6IBS0 1 +Glial cell development 0.2790630915149431 0.0256100259276589 0.9795683891600766 1.0 1.0 22 P08670,Q92542,O43175 3 +Left right axis specification 0.326809568188882 0.0252581540180997 0.9798490515287126 1.0 1.0 2 Q04721 1 +Left right pattern formation 0.326809568188882 0.0252581540180997 0.9798490515287126 1.0 1.0 2 Q04721 1 +Spinal cord development 0.2969992885039985 0.0248412896564909 0.9801815568263796 1.0 1.0 13 O43175 1 +Regulation of cytoplasmic mrna processing body assembly 0.3156259707983894 0.0247725606014913 0.9802363778076716 1.0 1.0 2 Q9HBH5 1 +Regulation of protein deacetylation 0.2875133772690982 0.0234474211433843 0.981293378787315 1.0 1.0 16 Q9UHR5,Q96ES7,P49354,P04637 4 +Striated muscle cell differentiation 0.2794579953612395 0.0234354548686278 0.9813029238703168 1.0 1.0 39 O75844,P10644,P02545,Q8IV08,Q96TA1,O75955,P11413 7 +Peptidyl cysteine modification 0.3229541938119601 0.0233811487328857 0.9813462420278892 1.0 1.0 7 Q96JJ7 1 +Regulation of centriole replication 0.3299129353233753 0.0224138849868945 0.9821178045167852 1.0 1.0 5 P38398,Q96PK6,P06748,O75351 4 +Activation of cysteine type endopeptidase activity 0.4210689869484327 0.022254476788611 0.9822449621388664 1.0 1.0 3 Q12797,Q99538 2 +Meiotic cell cycle 0.2636126547039492 0.0214599058569366 0.982878786582324 1.0 1.0 55 Q9UH99,P46379,Q9BXW9,Q8N2A8,Q15645,Q9BZD4,Q99640,Q92791,Q12768,Q9BTX1,Q9H2V7,O60566 12 +Extracellular exosome assembly 0.4188937228092064 0.0207587225047049 0.9834381253064746 1.0 1.0 3 Q92783,Q8WUM4 2 +Positive regulation of response to external stimulus 0.2582586903114449 0.0183196446615785 0.9853838559222144 1.0 1.0 58 Q8NE86,P11279,Q13641,P23246,Q8NHP6,Q9NUD5,Q8WXF1,Q15233,P05067,Q4KMQ2,Q6UWE0,Q08722,Q99735 13 +Negative regulation of wound healing 0.3256609642301652 0.0177738465111298 0.9858192689248476 1.0 1.0 6 O75122,P58107,P55011,O14936,P46108 5 +Positive regulation of rho protein signal transduction 0.4139216904910068 0.0174981535191177 0.986039205900006 1.0 1.0 3 Q9Y6N7,Q9Y624 2 +Regulation of lipopolysaccharide mediated signaling pathway 0.4137062715176456 0.017361776195138 0.9861480027334746 1.0 1.0 3 Q9UBC1 1 +Positive regulation of histone deacetylation 0.3197733286572073 0.0145353568553733 0.9884028715477516 1.0 1.0 7 Q9ULX6,Q9UHR5,P04637 3 +Physiological cardiac muscle hypertrophy 0.3559216661485934 0.0140039983900057 0.9888267910963032 1.0 1.0 4 Q9UGN5,O94826,P11413 3 +Regulation of wound healing 0.2860262008733623 0.0134541290362326 0.9892654820128536 1.0 1.0 15 Q92766,O75122,P42345,Q16625,P55011,Q4KMQ2,P05556,P46108,Q05397,P58107,O14936,P04083,Q7Z460,Q96AC1 14 +Regulation of gene silencing by rna 0.2847171637743015 0.0133477283261803 0.989350369873992 1.0 1.0 17 O75844 1 +Rab protein signal transduction 0.3552999689151469 0.0132785433087724 0.989405566639467 1.0 1.0 4 P31150,Q15286,P51151 3 +Negative regulation of dna damage response signal transduction by p53 class mediator 0.4058421379739048 0.0126522674106753 0.9899052205030908 1.0 1.0 3 O60341,P14174 2 +Negative regulation of leukocyte chemotaxis 0.404288377874472 0.0117822144839355 0.9905993704718408 1.0 1.0 3 O94813,P14174 2 +Hippocampus development 0.2832229715501801 0.0108751658470703 0.9913230441109409 1.0 1.0 18 O14949,Q13144,P07196 3 +Phototransduction visible light 0.3989796847279183 0.0089540099123111 0.9928558291969598 1.0 1.0 3 P50148 1 +Detection of visible light 0.3989796847279183 0.0089540099123111 0.9928558291969598 1.0 1.0 3 P50148 1 +Detection of light stimulus 0.3989796847279183 0.0089540099123111 0.9928558291969598 1.0 1.0 3 P50148 1 +Phototransduction 0.3989796847279183 0.0089540099123111 0.9928558291969598 1.0 1.0 3 P50148 1 +Nucleotide binding domain leucine rich repeat containing receptor signaling pathway 0.3983840894965933 0.0086503585153356 0.9930980985720328 1.0 1.0 3 Q96RT1,Q96J02 2 +Neuron death in response to oxidative stress 0.3170790948898467 0.0072258404876717 0.994234663606804 1.0 1.0 7 Q07820,O75915 2 +Regulation of dna duplex unwinding 0.3493938451973932 0.006650006912522 0.9946941012620608 1.0 1.0 4 P49736,Q04837,P33993 3 +Demethylation 0.2839265626658778 0.0056322269244166 0.995506156853016 1.0 1.0 16 Q16850 1 +Positive regulation of receptor catabolic process 0.3884400248601721 0.0039686226806655 0.9968335055474772 1.0 1.0 3 P18031,Q96J02 2 +Anterograde dendritic transport 0.386891896392668 0.0033031678452648 0.9973644581672204 1.0 1.0 3 Q14254 1 +Transmembrane receptor protein serine threonine kinase signaling pathway 0.2732330060569554 0.0022925100299095 0.9981708432438696 1.0 1.0 45 O00400,Q9UIQ6,P49354,Q92896,P08670 5 +Positive regulation of antigen receptor mediated signaling pathway 0.3837787445618532 0.0020142934851989 0.998392827414052 1.0 1.0 3 P23396,P05771 2 +Mature b cell differentiation 0.3837787445618459 0.0020142934851961 0.998392827414054 1.0 1.0 3 Q9UDY8,Q04721 2 +Snorna localization 0.3444202673298179 0.0014311892182174 0.9988580766090308 1.0 1.0 4 P22087,Q8WWY3,Q9NWS0 3 +Regulation of intrinsic apoptotic signaling pathway 0.2704001898473529 0.0013032044033957 0.9989601936212846 1.0 1.0 48 Q9P0J0,O60313,P04637,P51572,P45880,Q07820,O76024 7 +Regulation of lipid kinase activity 0.3026151930261492 0.0011354766949346 0.9990940208706413 1.0 1.0 9 P12931,P07948,Q8TBX8,P60953,Q05639,O00459,Q05397,A4D1P6 8 +Homologous recombination 0.3023867788516184 0.0003727915720771 0.9997025553671316 1.0 1.0 9 Q15645 1 diff --git a/msigdb_gobp/selections.json b/msigdb_gobp/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..e98099e9d354af5376205da457a2e909dce76320 --- /dev/null +++ b/msigdb_gobp/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["10 formyltetrahydrofolate metabolic process", "2 oxoglutarate metabolic process", "2fe 2s cluster assembly", "3 phosphoadenosine 5 phosphosulfate biosynthetic process", "3 phosphoadenosine 5 phosphosulfate metabolic process", "3 utr mediated mrna destabilization", "3 utr mediated mrna stabilization", "5 phosphoribose 1 diphosphate metabolic process", "5s class rrna transcription by rna polymerase iii", "Abscission", "Acetyl coa biosynthetic process", "Acetyl coa biosynthetic process from pyruvate", "Acetyl coa metabolic process", "Acid secretion", "Acidic amino acid transport", "Acrosome assembly", "Actin crosslink formation", "Actin cytoskeleton reorganization", "Actin filament based movement", "Actin filament based process", "Actin filament based transport", "Actin filament bundle organization", "Actin filament depolymerization", "Actin filament network formation", "Actin filament organization", "Actin filament polymerization", "Actin filament reorganization", "Actin filament severing", "Actin mediated cell contraction", "Actin modification", "Actin myosin filament sliding", "Actin nucleation", "Actin polymerization dependent cell motility", "Actin polymerization or depolymerization", "Action potential", "Activated t cell proliferation", "Activation induced cell death of t cells", "Activation of adenylate cyclase activity", "Activation of cysteine type endopeptidase activity", "Activation of cysteine type endopeptidase activity involved in apoptotic process", "Activation of gtpase activity", "Activation of immune response", "Activation of innate immune response", "Activation of nf kappab inducing kinase activity", "Activation of phospholipase c activity", "Activation of phospholipase d activity", "Activation of protein kinase activity", "Activation of protein kinase b activity", "Activation of protein kinase c activity", "Activin receptor signaling pathway", "Actomyosin contractile ring organization", "Actomyosin structure organization", "Acute inflammatory response", "Acute inflammatory response to antigenic stimulus", "Acute phase response", "Acyl carnitine transmembrane transport", "Acylglycerol homeostasis", "Adaptation of signaling pathway", "Adaptive immune response", "Adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains", "Adaptive thermogenesis", "Adenosine metabolic process", "Adenosine to inosine editing", "Adenylate cyclase activating adrenergic receptor signaling pathway", "Adenylate cyclase activating adrenergic receptor signaling pathway involved in heart process", "Adenylate cyclase activating dopamine receptor signaling pathway", "Adenylate cyclase activating g protein coupled receptor signaling pathway", "Adenylate cyclase inhibiting dopamine receptor signaling pathway", "Adenylate cyclase inhibiting g protein coupled receptor signaling pathway", "Adenylate cyclase modulating g protein coupled receptor signaling pathway", "Adherens junction assembly", "Adherens junction maintenance", "Adherens junction organization", "Adhesion of symbiont to host", "Adhesion of symbiont to host cell", "Adiponectin activated signaling pathway", "Adipose tissue development", "Adp biosynthetic process", "Adp metabolic process", "Adp transport", "Adrenal gland development", "Adrenergic receptor signaling pathway", "Adult behavior", "Adult locomotory behavior", "Aerobic respiration", "Aggrephagy", "Aggresome assembly", "Aging", "Alanine catabolic process", "Alanine transport", "Alcohol biosynthetic process", "Alcohol catabolic process", "Alcohol metabolic process", "Aldehyde biosynthetic process", "Aldehyde catabolic process", "Alditol biosynthetic process", "Alditol catabolic process", "Alditol metabolic process", "Alditol phosphate metabolic process", "Alkanesulfonate metabolic process", "Allantoin metabolic process", "Alpha amino acid catabolic process", "Alpha amino acid metabolic process", "Alpha beta t cell activation", "Alpha beta t cell differentiation", "Alpha beta t cell proliferation", "Alpha ketoglutarate transport", "Alpha linolenic acid metabolic process", "Alternative mrna splicing via spliceosome", "Ameboidal type cell migration", "Amelogenesis", "Amide biosynthetic process", "Amide transport", "Amine biosynthetic process", "Amine catabolic process", "Amine metabolic process", "Amine transport", "Amino acid activation", "Amino acid betaine biosynthetic process", "Amino acid betaine metabolic process", "Amino acid betaine transport", "Amino acid homeostasis", "Amino acid import", "Amino acid import across plasma membrane", "Amino acid neurotransmitter reuptake", "Amino acid salvage", "Amino acid transmembrane transport", "Amino acid transport", "Amino sugar biosynthetic process", "Amino sugar catabolic process", "Amino sugar metabolic process", "Aminoacyl trna metabolism involved in translational fidelity", "Aminoglycan biosynthetic process", "Aminoglycan catabolic process", "Aminoglycan metabolic process", "Aminoglycoside antibiotic metabolic process", "Aminophospholipid transport", "Ammonium ion metabolic process", "Ammonium transmembrane transport", "Amp biosynthetic process", "Amp catabolic process", "Amp metabolic process", "Amp salvage", "Ampa glutamate receptor clustering", "Amygdala development", "Amyloid beta clearance", "Amyloid beta clearance by cellular catabolic process", "Amyloid beta clearance by transcytosis", "Amyloid beta formation", "Amyloid beta metabolic process", "Amyloid fibril formation", "Amyloid precursor protein biosynthetic process", "Amyloid precursor protein catabolic process", "Amyloid precursor protein metabolic process", "Anagen", "Anaphase promoting complex dependent catabolic process", "Anatomical structure arrangement", "Anatomical structure formation involved in morphogenesis", "Anatomical structure homeostasis", "Anatomical structure maturation", "Androgen catabolic process", "Androgen metabolic process", "Androgen receptor signaling pathway", "Angiogenesis involved in coronary vascular morphogenesis", "Angiogenesis involved in wound healing", "Angiotensin activated signaling pathway", "Animal organ formation", "Animal organ maturation", "Animal organ morphogenesis", "Animal organ regeneration", "Anion homeostasis", "Anion transmembrane transport", "Anion transport", "Anoikis", "Anterior head development", "Anterior posterior axis specification", "Anterior posterior pattern specification", "Anterograde axonal transport", "Anterograde axonal transport of mitochondrion", "Anterograde dendritic transport", "Anterograde dendritic transport of neurotransmitter receptor complex", "Anterograde neuronal dense core vesicle transport", "Antibacterial humoral response", "Antigen processing and presentation", "Antigen processing and presentation of endogenous antigen", "Antigen processing and presentation of endogenous peptide antigen", "Antigen processing and presentation of endogenous peptide antigen via mhc class i via er pathway", "Antigen processing and presentation of exogenous antigen", "Antigen processing and presentation of exogenous peptide antigen", "Antigen processing and presentation of exogenous peptide antigen via mhc class i", "Antigen processing and presentation of exogenous peptide antigen via mhc class ii", "Antigen processing and presentation of lipid antigen via mhc class ib", "Antigen processing and presentation of peptide antigen", "Antigen processing and presentation of peptide antigen via mhc class i", "Antigen processing and presentation of peptide antigen via mhc class ib", "Antigen processing and presentation of peptide or polysaccharide antigen via mhc class ii", "Antigen processing and presentation via mhc class ib", "Antigen receptor mediated signaling pathway", "Antimicrobial humoral immune response mediated by antimicrobial peptide", "Antimicrobial humoral response", "Antiviral innate immune response", "Aorta development", "Aorta morphogenesis", "Aortic valve morphogenesis", "Apical junction assembly", "Apical protein localization", "Apoptotic cell clearance", "Apoptotic chromosome condensation", "Apoptotic dna fragmentation", "Apoptotic mitochondrial changes", "Apoptotic process involved in development", "Apoptotic process involved in heart morphogenesis", "Apoptotic process involved in morphogenesis", "Apoptotic signaling pathway", "Appendage development", "Appendage morphogenesis", "Arachidonic acid metabolic process", "Arachidonic acid secretion", "Arf protein signal transduction", "Arginine catabolic process", "Arginine metabolic process", "Aromatic amino acid family catabolic process", "Aromatic amino acid family metabolic process", "Aromatic amino acid transport", "Arp2 3 complex mediated actin nucleation", "Arterial endothelial cell differentiation", "Artery development", "Artery morphogenesis", "Asparagine metabolic process", "Aspartate family amino acid biosynthetic process", "Aspartate family amino acid catabolic process", "Aspartate family amino acid metabolic process", "Aspartate metabolic process", "Aspartate transmembrane transport", "Associative learning", "Astral microtubule organization", "Astrocyte activation", "Astrocyte cell migration", "Astrocyte development", "Astrocyte differentiation", "Asymmetric cell division", "Asymmetric neuroblast division", "Atf6 mediated unfolded protein response", "Atp biosynthetic process", "Atp metabolic process", "Atp synthesis coupled electron transport", "Atp synthesis coupled proton transport", "Atp transport", "Atrial cardiac muscle cell membrane repolarization", "Atrial cardiac muscle cell to av node cell signaling", "Atrial septum development", "Atrial septum morphogenesis", "Atrioventricular canal development", "Atrioventricular node development", "Attachment of gpi anchor to protein", "Attachment of mitotic spindle microtubules to kinetochore", "Attachment of spindle microtubules to kinetochore", "Auditory receptor cell development", "Auditory receptor cell morphogenesis", "Autonomic nervous system development", "Autophagic cell death", "Autophagosome maturation", "Autophagosome membrane docking", "Autophagosome organization", "Autophagy of mitochondrion", "Autophagy of nucleus", "Autophagy of peroxisome", "Av node cell to bundle of his cell communication", "Av node cell to bundle of his cell signaling", "Axial mesoderm development", "Axis elongation", "Axis specification", "Axo dendritic protein transport", "Axo dendritic transport", "Axon choice point recognition", "Axon development", "Axon ensheathment in central nervous system", "Axon extension", "Axon midline choice point recognition", "Axonal fasciculation", "Axonal transport", "Axonal transport of mitochondrion", "Axonemal dynein complex assembly", "Axoneme assembly", "Axonogenesis involved in innervation", "Azole transmembrane transport", "B 1 b cell differentiation", "B cell activation", "B cell activation involved in immune response", "B cell apoptotic process", "B cell differentiation", "B cell homeostasis", "B cell lineage commitment", "B cell mediated immunity", "B cell proliferation", "B cell receptor signaling pathway", "Barbed end actin filament capping", "Base conversion or substitution editing", "Base excision repair", "Base excision repair ap site formation", "Base excision repair gap filling", "Basement membrane assembly", "Basement membrane organization", "Basic amino acid transport", "Behavior", "Behavioral response to cocaine", "Behavioral response to ethanol", "Behavioral response to pain", "Benzene containing compound metabolic process", "Bergmann glial cell differentiation", "Bicarbonate transport", "Bile acid and bile salt transport", "Bile acid biosynthetic process", "Bile acid metabolic process", "Bile acid secretion", "Bile acid signaling pathway", "Binding of sperm to zona pellucida", "Biological adhesion", "Biological phase", "Biological process involved in interaction with host", "Biological process involved in interaction with symbiont", "Biological process involved in interspecies interaction between organisms", "Biological process involved in intraspecies interaction between organisms", "Biological process involved in symbiotic interaction", "Biomineralization", "Blastocyst development", "Blastocyst formation", "Blastocyst growth", "Blastoderm segmentation", "Bleb assembly", "Blood vessel endothelial cell differentiation", "Blood vessel endothelial cell migration", "Blood vessel endothelial cell proliferation involved in sprouting angiogenesis", "Blood vessel maturation", "Blood vessel morphogenesis", "Blood vessel remodeling", "Body fluid secretion", "Body morphogenesis", "Bone cell development", "Bone development", "Bone growth", "Bone marrow development", "Bone maturation", "Bone mineralization", "Bone morphogenesis", "Bone remodeling", "Bone resorption", "Box c d snornp assembly", "Bradykinin catabolic process", "Brain derived neurotrophic factor receptor signaling pathway", "Brain morphogenesis", "Brainstem development", "Branched chain amino acid biosynthetic process", "Branched chain amino acid catabolic process", "Branched chain amino acid metabolic process", "Branched chain amino acid transport", "Branching involved in blood vessel morphogenesis", "Branching involved in labyrinthine layer morphogenesis", "Branching involved in mammary gland duct morphogenesis", "Branching involved in salivary gland morphogenesis", "Branching morphogenesis of a nerve", "Branching morphogenesis of an epithelial tube", "Branchiomotor neuron axon guidance", "Brown fat cell differentiation", "Bundle of his cell to purkinje myocyte communication", "C 5 methylation of cytosine", "C terminal protein amino acid modification", "C terminal protein lipidation", "C21 steroid hormone biosynthetic process", "C21 steroid hormone metabolic process", "C4 dicarboxylate transport", "Cadmium ion transmembrane transport", "Calcineurin mediated signaling", "Calcium activated phospholipid scrambling", "Calcium dependent cell cell adhesion via plasma membrane cell adhesion molecules", "Calcium import into the mitochondrion", "Calcium ion export", "Calcium ion export across plasma membrane", "Calcium ion import", "Calcium ion import into cytosol", "Calcium ion import into sarcoplasmic reticulum", "Calcium ion regulated exocytosis", "Calcium ion regulated exocytosis of neurotransmitter", "Calcium ion transmembrane transport", "Calcium ion transmembrane transport via high voltage gated calcium channel", "Calcium ion transport", "Calcium ion transport into cytosol", "Calcium mediated signaling", "Calcium mediated signaling using intracellular calcium source", "Calmodulin dependent kinase signaling pathway", "Camera type eye development", "Camera type eye morphogenesis", "Camera type eye photoreceptor cell differentiation", "Camp mediated signaling", "Cannabinoid signaling pathway", "Canonical wnt signaling pathway", "Canonical wnt signaling pathway involved in cardiac muscle cell fate commitment", "Canonical wnt signaling pathway involved in heart development", "Canonical wnt signaling pathway involved in osteoblast differentiation", "Canonical wnt signaling pathway involved in regulation of cell proliferation", "Cap dependent translational initiation", "Carbohydrate biosynthetic process", "Carbohydrate catabolic process", "Carbohydrate derivative biosynthetic process", "Carbohydrate derivative catabolic process", "Carbohydrate derivative metabolic process", "Carbohydrate derivative transport", "Carbohydrate homeostasis", "Carbohydrate mediated signaling", "Carbohydrate metabolic process", "Carbohydrate phosphorylation", "Carbohydrate transmembrane transport", "Carbohydrate transport", "Carboxylic acid transport", "Cardiac atrium development", "Cardiac atrium morphogenesis", "Cardiac cell development", "Cardiac cell fate commitment", "Cardiac chamber development", "Cardiac chamber morphogenesis", "Cardiac conduction", "Cardiac conduction system development", "Cardiac epithelial to mesenchymal transition", "Cardiac left ventricle morphogenesis", "Cardiac muscle cell action potential", "Cardiac muscle cell action potential involved in contraction", "Cardiac muscle cell cardiac muscle cell adhesion", "Cardiac muscle cell contraction", "Cardiac muscle cell differentiation", "Cardiac muscle cell fate commitment", "Cardiac muscle cell membrane repolarization", "Cardiac muscle cell myoblast differentiation", "Cardiac muscle cell proliferation", "Cardiac muscle contraction", "Cardiac muscle tissue development", "Cardiac muscle tissue morphogenesis", "Cardiac neural crest cell development involved in outflow tract morphogenesis", "Cardiac neural crest cell differentiation involved in heart development", "Cardiac neural crest cell migration involved in outflow tract morphogenesis", "Cardiac septum development", "Cardiac septum morphogenesis", "Cardiac ventricle development", "Cardiac ventricle morphogenesis", "Cardioblast differentiation", "Cardioblast proliferation", "Cardiocyte differentiation", "Cardiolipin acyl chain remodeling", "Cardiolipin biosynthetic process", "Cardiolipin metabolic process", "Carnitine metabolic process", "Carnitine transport", "Cartilage development", "Cartilage development involved in endochondral bone morphogenesis", "Catechol containing compound biosynthetic process", "Catechol containing compound catabolic process", "Catechol containing compound metabolic process", "Catecholamine uptake", "Catecholamine uptake involved in synaptic transmission", "Cation transmembrane transport", "Cation transport", "Caveola assembly", "Caveolin mediated endocytosis", "Cd4 positive alpha beta t cell activation", "Cd4 positive alpha beta t cell differentiation", "Cd4 positive alpha beta t cell proliferation", "Cd4 positive or cd8 positive alpha beta t cell lineage commitment", "Cd40 signaling pathway", "Cd8 positive alpha beta t cell activation", "Cd8 positive alpha beta t cell proliferation", "Cdc42 protein signal transduction", "Cdp choline pathway", "Cdp diacylglycerol metabolic process", "Cell activation", "Cell activation involved in immune response", "Cell adhesion mediated by integrin", "Cell adhesion molecule production", "Cell aggregation", "Cell aging", "Cell cell adhesion", "Cell cell adhesion mediated by cadherin", "Cell cell adhesion mediated by integrin", "Cell cell adhesion via plasma membrane adhesion molecules", "Cell cell junction assembly", "Cell cell junction maintenance", "Cell cell junction organization", "Cell cell recognition", "Cell cell signaling", "Cell cell signaling by wnt", "Cell cell signaling involved in cardiac conduction", "Cell chemotaxis", "Cell communication by electrical coupling", "Cell communication by electrical coupling involved in cardiac conduction", "Cell communication involved in cardiac conduction", "Cell cycle", "Cell cycle checkpoint signaling", "Cell cycle dna replication", "Cell cycle dna replication initiation", "Cell cycle g1 s phase transition", "Cell cycle g2 m phase transition", "Cell cycle phase transition", "Cell cycle process", "Cell death in response to hydrogen peroxide", "Cell death in response to oxidative stress", "Cell differentiation in hindbrain", "Cell differentiation in spinal cord", "Cell differentiation involved in embryonic placenta development", "Cell differentiation involved in kidney development", "Cell differentiation involved in metanephros development", "Cell differentiation involved in phenotypic switching", "Cell division", "Cell fate commitment", "Cell fate commitment involved in formation of primary germ layer", "Cell fate determination", "Cell fate specification", "Cell growth", "Cell junction assembly", "Cell junction disassembly", "Cell junction maintenance", "Cell junction organization", "Cell killing", "Cell matrix adhesion", "Cell maturation", "Cell migration", "Cell migration in hindbrain", "Cell migration involved in gastrulation", "Cell migration involved in heart development", "Cell migration involved in kidney development", "Cell migration involved in sprouting angiogenesis", "Cell morphogenesis", "Cell morphogenesis involved in differentiation", "Cell morphogenesis involved in neuron differentiation", "Cell motility involved in cerebral cortex radial glia guided migration", "Cell part morphogenesis", "Cell projection assembly", "Cell projection organization", "Cell proliferation in forebrain", "Cell proliferation in hindbrain", "Cell proliferation involved in heart morphogenesis", "Cell proliferation involved in kidney development", "Cell proliferation involved in metanephros development", "Cell recognition", "Cell redox homeostasis", "Cell substrate adhesion", "Cell substrate junction organization", "Cell surface receptor signaling pathway involved in cell cell signaling", "Cell surface receptor signaling pathway involved in heart development", "Cell volume homeostasis", "Cellular aldehyde metabolic process", "Cellular amide metabolic process", "Cellular amino acid biosynthetic process", "Cellular amino acid catabolic process", "Cellular amino acid metabolic process", "Cellular anion homeostasis", "Cellular carbohydrate biosynthetic process", "Cellular carbohydrate catabolic process", "Cellular carbohydrate metabolic process", "Cellular component assembly involved in morphogenesis", "Cellular component disassembly", "Cellular component disassembly involved in execution phase of apoptosis", "Cellular component maintenance", "Cellular component morphogenesis", "Cellular copper ion homeostasis", "Cellular defense response", "Cellular detoxification of aldehyde", "Cellular extravasation", "Cellular glucan metabolic process", "Cellular glucose homeostasis", "Cellular homeostasis", "Cellular hormone metabolic process", "Cellular hyperosmotic response", "Cellular hyperosmotic salinity response", "Cellular hypotonic response", "Cellular ion homeostasis", "Cellular iron ion homeostasis", "Cellular ketone metabolic process", "Cellular lipid catabolic process", "Cellular lipid metabolic process", "Cellular macromolecule biosynthetic process", "Cellular macromolecule localization", "Cellular metabolic compound salvage", "Cellular modified amino acid biosynthetic process", "Cellular modified amino acid catabolic process", "Cellular modified amino acid metabolic process", "Cellular monovalent inorganic anion homeostasis", "Cellular monovalent inorganic cation homeostasis", "Cellular nitrogen compound catabolic process", "Cellular oxidant detoxification", "Cellular pigmentation", "Cellular polysaccharide catabolic process", "Cellular potassium ion homeostasis", "Cellular process involved in reproduction in multicellular organism", "Cellular protein catabolic process", "Cellular respiration", "Cellular response to abiotic stimulus", "Cellular response to acid chemical", "Cellular response to acidic ph", "Cellular response to alcohol", "Cellular response to aldehyde", "Cellular response to alkaloid", "Cellular response to amyloid beta", "Cellular response to antibiotic", "Cellular response to arsenic containing substance", "Cellular response to atp", "Cellular response to biotic stimulus", "Cellular response to brain derived neurotrophic factor stimulus", "Cellular response to cadmium ion", "Cellular response to calcium ion", "Cellular response to camp", "Cellular response to carbohydrate stimulus", "Cellular response to chemical stress", "Cellular response to cold", "Cellular response to copper ion", "Cellular response to corticosteroid stimulus", "Cellular response to dexamethasone stimulus", "Cellular response to dna damage stimulus", "Cellular response to dsrna", "Cellular response to electrical stimulus", "Cellular response to endogenous stimulus", "Cellular response to epinephrine stimulus", "Cellular response to estradiol stimulus", "Cellular response to estrogen stimulus", "Cellular response to ethanol", "Cellular response to ether", "Cellular response to exogenous dsrna", "Cellular response to external stimulus", "Cellular response to extracellular stimulus", "Cellular response to fatty acid", "Cellular response to fluid shear stress", "Cellular response to follicle stimulating hormone stimulus", "Cellular response to gamma radiation", "Cellular response to glucose starvation", "Cellular response to gonadotropin stimulus", "Cellular response to growth hormone stimulus", "Cellular response to heat", "Cellular response to heparin", "Cellular response to histamine", "Cellular response to hormone stimulus", "Cellular response to hydrogen peroxide", "Cellular response to hyperoxia", "Cellular response to increased oxygen levels", "Cellular response to indole 3 methanol", "Cellular response to inorganic substance", "Cellular response to insulin like growth factor stimulus", "Cellular response to insulin stimulus", "Cellular response to interferon alpha", "Cellular response to interferon beta", "Cellular response to interferon gamma", "Cellular response to interleukin 1", "Cellular response to ionizing radiation", "Cellular response to iron ion", "Cellular response to ketone", "Cellular response to leptin stimulus", "Cellular response to leucine", "Cellular response to leucine starvation", "Cellular response to light intensity", "Cellular response to light stimulus", "Cellular response to lipid", "Cellular response to lipoprotein particle stimulus", "Cellular response to lithium ion", "Cellular response to low density lipoprotein particle stimulus", "Cellular response to magnesium ion", "Cellular response to manganese ion", "Cellular response to mechanical stimulus", "Cellular response to mineralocorticoid stimulus", "Cellular response to molecule of bacterial origin", "Cellular response to muramyl dipeptide", "Cellular response to nitrogen compound", "Cellular response to nitrogen starvation", "Cellular response to nitrosative stress", "Cellular response to nutrient", "Cellular response to organic cyclic compound", "Cellular response to osmotic stress", "Cellular response to oxidised low density lipoprotein particle stimulus", "Cellular response to oxygen containing compound", "Cellular response to oxygen glucose deprivation", "Cellular response to oxygen levels", "Cellular response to oxygen radical", "Cellular response to parathyroid hormone stimulus", "Cellular response to peptide", "Cellular response to peptide hormone stimulus", "Cellular response to peptidoglycan", "Cellular response to ph", "Cellular response to potassium ion", "Cellular response to progesterone stimulus", "Cellular response to prostaglandin e stimulus", "Cellular response to prostaglandin stimulus", "Cellular response to radiation", "Cellular response to reactive nitrogen species", "Cellular response to reactive oxygen species", "Cellular response to retinoic acid", "Cellular response to salt", "Cellular response to salt stress", "Cellular response to sodium arsenite", "Cellular response to starvation", "Cellular response to steroid hormone stimulus", "Cellular response to sterol depletion", "Cellular response to stress", "Cellular response to testosterone stimulus", "Cellular response to thyroid hormone stimulus", "Cellular response to topologically incorrect protein", "Cellular response to toxic substance", "Cellular response to unfolded protein", "Cellular response to uv", "Cellular response to uv a", "Cellular response to uv c", "Cellular response to vascular endothelial growth factor stimulus", "Cellular response to virus", "Cellular response to vitamin", "Cellular response to vitamin d", "Cellular response to water stimulus", "Cellular response to x ray", "Cellular response to xenobiotic stimulus", "Cellular response to zinc ion", "Cellular senescence", "Cellular sodium ion homeostasis", "Cellular sphingolipid homeostasis", "Cellular transition metal ion homeostasis", "Cellular triglyceride homeostasis", "Cellular trivalent inorganic anion homeostasis", "Cenp a containing chromatin organization", "Central nervous system development", "Central nervous system maturation", "Central nervous system myelin formation", "Central nervous system neuron axonogenesis", "Central nervous system neuron development", "Central nervous system neuron differentiation", "Central nervous system projection neuron axonogenesis", "Centriole assembly", "Centriole centriole cohesion", "Centriole elongation", "Centromere complex assembly", "Centromeric sister chromatid cohesion", "Centrosome duplication", "Centrosome separation", "Ceramide 1 phosphate transport", "Ceramide biosynthetic process", "Ceramide catabolic process", "Ceramide metabolic process", "Ceramide transport", "Cerebellar cortex development", "Cerebellar cortex formation", "Cerebellar cortex morphogenesis", "Cerebellar granular layer development", "Cerebellar granular layer formation", "Cerebellar granular layer morphogenesis", "Cerebellar purkinje cell layer development", "Cerebellar purkinje cell layer formation", "Cerebellar purkinje cell layer morphogenesis", "Cerebral cortex cell migration", "Cerebral cortex development", "Cerebral cortex neuron differentiation", "Cerebral cortex radially oriented cell migration", "Cerebral cortex regionalization", "Cerebral cortex tangential migration", "Cerebrospinal fluid circulation", "Cgmp mediated signaling", "Changes to dna methylation involved in embryo development", "Chaperone cofactor dependent protein refolding", "Chaperone mediated autophagy", "Chaperone mediated protein complex assembly", "Chaperone mediated protein folding", "Chemical homeostasis", "Chemical homeostasis within a tissue", "Chemical synaptic transmission postsynaptic", "Chemokine c c motif ligand 5 production", "Chemokine c x c motif ligand 12 signaling pathway", "Chemokine c x c motif ligand 2 production", "Chemokine production", "Chemosensory behavior", "Chloride transmembrane transport", "Chloride transport", "Cholesterol catabolic process", "Cholesterol efflux", "Cholesterol storage", "Choline metabolic process", "Chondrocyte development", "Chondrocyte development involved in endochondral bone morphogenesis", "Chondrocyte differentiation", "Chondrocyte differentiation involved in endochondral bone morphogenesis", "Chondrocyte proliferation", "Chondroitin sulfate biosynthetic process", "Chondroitin sulfate proteoglycan biosynthetic process", "Chondroitin sulfate proteoglycan metabolic process", "Chorion development", "Chromatin assembly or disassembly", "Chromatin disassembly", "Chromatin organization", "Chromatin remodeling", "Chromatin remodeling at centromere", "Chromosome attachment to the nuclear envelope", "Chromosome condensation", "Chromosome localization", "Chromosome localization to nuclear envelope involved in homologous chromosome segregation", "Chromosome movement towards spindle pole", "Chromosome organization", "Chromosome organization involved in meiotic cell cycle", "Chromosome segregation", "Chromosome separation", "Cilium movement", "Cilium or flagellum dependent cell motility", "Cilium organization", "Circadian regulation of gene expression", "Circadian rhythm", "Circulatory system development", "Circulatory system process", "Citrate metabolic process", "Citrulline biosynthetic process", "Citrulline metabolic process", "Clathrin coat assembly", "Clathrin dependent endocytosis", "Cleavage furrow formation", "Cleavage involved in rrna processing", "Cobalamin metabolic process", "Cochlea development", "Cochlea morphogenesis", "Coenzyme a biosynthetic process", "Coenzyme a metabolic process", "Cognition", "Cohesin loading", "Collagen biosynthetic process", "Collagen catabolic process", "Collagen fibril organization", "Collagen metabolic process", "Collateral sprouting", "Collateral sprouting in absence of injury", "Collecting duct development", "Columnar cuboidal epithelial cell development", "Columnar cuboidal epithelial cell differentiation", "Columnar cuboidal epithelial cell maturation", "Commissural neuron axon guidance", "Common bile duct development", "Common partner smad protein phosphorylation", "Complement activation", "Complement dependent cytotoxicity", "Connective tissue development", "Connective tissue replacement", "Constitutive heterochromatin assembly", "Constitutive secretory pathway", "Convergent extension", "Convergent extension involved in axis elongation", "Cop9 signalosome assembly", "Copi coated vesicle budding", "Copii coated vesicle budding", "Copii coated vesicle cargo loading", "Copper ion homeostasis", "Copper ion import", "Copper ion transmembrane transport", "Copper ion transport", "Copulation", "Coronary artery morphogenesis", "Coronary vasculature development", "Coronary vasculature morphogenesis", "Corpus callosum development", "Corpus callosum morphogenesis", "Cortical actin cytoskeleton organization", "Cortical cytoskeleton organization", "Corticospinal tract morphogenesis", "Corticosteroid hormone secretion", "Corticosteroid receptor signaling pathway", "Cortisol secretion", "Cotranslational protein targeting to membrane", "Cranial ganglion development", "Cranial nerve development", "Cranial nerve morphogenesis", "Cranial nerve structural organization", "Cranial skeletal system development", "Craniofacial suture morphogenesis", "Crd mediated mrna stabilization", "Cristae formation", "Cyclic gmp amp transmembrane import across plasma membrane", "Cyclic nucleotide catabolic process", "Cyclic nucleotide mediated signaling", "Cyclic nucleotide metabolic process", "Cyclooxygenase pathway", "Cysteine metabolic process", "Cytidine to uridine editing", "Cytochrome complex assembly", "Cytokine mediated signaling pathway", "Cytokine production", "Cytokine production involved in immune response", "Cytokine production involved in inflammatory response", "Cytokinesis", "Cytokinetic process", "Cytoplasm organization", "Cytoplasmic microtubule organization", "Cytoplasmic pattern recognition receptor signaling pathway", "Cytoplasmic pattern recognition receptor signaling pathway in response to virus", "Cytoplasmic sequestering of nf kappab", "Cytoplasmic sequestering of protein", "Cytoplasmic sequestering of transcription factor", "Cytoplasmic translation", "Cytoplasmic translational elongation", "Cytoplasmic translational initiation", "Cytoskeleton dependent cytokinesis", "Cytoskeleton dependent intracellular transport", "Cytoskeleton organization", "Cytosolic calcium ion transport", "Cytosolic transport", "D amino acid transport", "Damp metabolic process", "De novo amp biosynthetic process", "De novo protein folding", "De novo pyrimidine nucleobase biosynthetic process", "Deadenylation dependent decapping of nuclear transcribed mrna", "Decidualization", "Dedifferentiation", "Defense response", "Defense response to bacterium", "Defense response to fungus", "Defense response to gram negative bacterium", "Defense response to gram positive bacterium", "Defense response to other organism", "Defense response to symbiont", "Defense response to tumor cell", "Definitive erythrocyte differentiation", "Definitive hemopoiesis", "Delamination", "Demethylation", "Dendrite arborization", "Dendrite development", "Dendrite extension", "Dendrite morphogenesis", "Dendrite self avoidance", "Dendritic cell apoptotic process", "Dendritic cell chemotaxis", "Dendritic cell cytokine production", "Dendritic cell differentiation", "Dendritic cell migration", "Dendritic spine development", "Dendritic spine maintenance", "Dendritic spine morphogenesis", "Dendritic transport", "Dense core granule transport", "Dentate gyrus development", "Deoxyribonucleoside catabolic process", "Deoxyribonucleoside diphosphate metabolic process", "Deoxyribonucleoside metabolic process", "Deoxyribonucleoside monophosphate biosynthetic process", "Deoxyribonucleoside monophosphate catabolic process", "Deoxyribonucleoside monophosphate metabolic process", "Deoxyribonucleoside triphosphate biosynthetic process", "Deoxyribonucleoside triphosphate catabolic process", "Deoxyribonucleoside triphosphate metabolic process", "Deoxyribonucleotide biosynthetic process", "Deoxyribose phosphate catabolic process", "Deoxyribose phosphate metabolic process", "Dephosphorylation", "Dephosphorylation of rna polymerase ii c terminal domain", "Depyrimidination", "Dermatan sulfate biosynthetic process", "Dermatan sulfate metabolic process", "Dermatan sulfate proteoglycan metabolic process", "Desmosome organization", "Detection of abiotic stimulus", "Detection of biotic stimulus", "Detection of cell density", "Detection of external biotic stimulus", "Detection of light stimulus", "Detection of mechanical stimulus", "Detection of molecule of bacterial origin", "Detection of muscle stretch", "Detection of other organism", "Detection of stimulus", "Detection of virus", "Detection of visible light", "Determination of adult lifespan", "Determination of dorsal ventral asymmetry", "Detoxification", "Detoxification of copper ion", "Detoxification of nitrogen compound", "Development of primary female sexual characteristics", "Development of primary sexual characteristics", "Development of secondary female sexual characteristics", "Development of secondary sexual characteristics", "Developmental cell growth", "Developmental growth", "Developmental growth involved in morphogenesis", "Developmental induction", "Developmental maturation", "Developmental pigmentation", "Developmental process involved in reproduction", "Diacylglycerol biosynthetic process", "Diacylglycerol metabolic process", "Diadenosine polyphosphate metabolic process", "Diapedesis", "Diaphragm development", "Dicarboxylic acid biosynthetic process", "Dicarboxylic acid catabolic process", "Dicarboxylic acid metabolic process", "Dicarboxylic acid transport", "Dichotomous subdivision of an epithelial terminal unit", "Dichotomous subdivision of terminal units involved in salivary gland branching", "Diencephalon development", "Digestion", "Digestive system development", "Digestive system process", "Digestive tract morphogenesis", "Diol biosynthetic process", "Diol metabolic process", "Disaccharide metabolic process", "Diterpenoid biosynthetic process", "Divalent inorganic cation homeostasis", "Dna biosynthetic process", "Dna catabolic process", "Dna catabolic process endonucleolytic", "Dna catabolic process exonucleolytic", "Dna conformation change", "Dna damage response signal transduction by p53 class mediator", "Dna damage response signal transduction by p53 class mediator resulting in cell cycle arrest", "Dna damage response signal transduction resulting in transcription", "Dna dealkylation", "Dna dealkylation involved in dna repair", "Dna deamination", "Dna dependent dna replication", "Dna dependent dna replication maintenance of fidelity", "Dna double strand break processing", "Dna endoreduplication", "Dna geometric change", "Dna integration", "Dna integrity checkpoint signaling", "Dna ligation", "Dna ligation involved in dna repair", "Dna metabolic process", "Dna methylation", "Dna methylation dependent heterochromatin assembly", "Dna methylation involved in gamete generation", "Dna methylation on cytosine", "Dna methylation or demethylation", "Dna modification", "Dna packaging", "Dna protection", "Dna recombination", "Dna repair", "Dna replication", "Dna replication checkpoint signaling", "Dna replication dependent chromatin organization", "Dna replication independent chromatin organization", "Dna replication initiation", "Dna replication synthesis of rna primer", "Dna strand elongation", "Dna strand elongation involved in dna replication", "Dna synthesis involved in dna repair", "Dna templated transcription elongation", "Dna templated transcription initiation", "Dna templated transcription termination", "Dna topological change", "Dna unwinding involved in dna replication", "Dolichol metabolic process", "Dolichyl diphosphate biosynthetic process", "Dopamine biosynthetic process", "Dopamine metabolic process", "Dopamine receptor signaling pathway", "Dopamine transport", "Dopaminergic neuron differentiation", "Dorsal aorta development", "Dorsal aorta morphogenesis", "Dorsal root ganglion development", "Dorsal ventral axis specification", "Dorsal ventral neural tube patterning", "Dorsal ventral pattern formation", "Dosage compensation", "Double strand break repair", "Double strand break repair involved in meiotic recombination", "Double strand break repair via break induced replication", "Double strand break repair via classical nonhomologous end joining", "Double strand break repair via nonhomologous end joining", "Dsrna processing", "Dtmp metabolic process", "Dttp metabolic process", "Dump metabolic process", "Ear development", "Ear morphogenesis", "Early endosome to golgi transport", "Eating behavior", "Ectoderm development", "Ectodermal cell differentiation", "Ectodermal placode development", "Ectopic germ cell programmed cell death", "Egg activation", "Elastic fiber assembly", "Elastin metabolic process", "Electron transport chain", "Embryo development", "Embryo development ending in birth or egg hatching", "Embryo implantation", "Embryonic appendage morphogenesis", "Embryonic axis specification", "Embryonic body morphogenesis", "Embryonic brain development", "Embryonic camera type eye development", "Embryonic cleavage", "Embryonic cranial skeleton morphogenesis", "Embryonic digestive tract development", "Embryonic digestive tract morphogenesis", "Embryonic digit morphogenesis", "Embryonic forelimb morphogenesis", "Embryonic heart tube development", "Embryonic heart tube morphogenesis", "Embryonic hemopoiesis", "Embryonic hindlimb morphogenesis", "Embryonic morphogenesis", "Embryonic neurocranium morphogenesis", "Embryonic organ development", "Embryonic organ morphogenesis", "Embryonic pattern specification", "Embryonic placenta development", "Embryonic placenta morphogenesis", "Embryonic process involved in female pregnancy", "Embryonic skeletal joint development", "Embryonic skeletal joint morphogenesis", "Embryonic skeletal system development", "Embryonic skeletal system morphogenesis", "Embryonic viscerocranium morphogenesis", "Enamel mineralization", "Endocannabinoid signaling pathway", "Endocardial cushion development", "Endocardial cushion formation", "Endocardial cushion morphogenesis", "Endocardium development", "Endocardium morphogenesis", "Endochondral bone morphogenesis", "Endocrine hormone secretion", "Endocrine pancreas development", "Endocrine process", "Endocrine system development", "Endocytic recycling", "Endocytosis", "Endoderm development", "Endoderm formation", "Endodermal cell differentiation", "Endodermal cell fate commitment", "Endomembrane system organization", "Endonucleolytic cleavage in 5 ets of tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna", "Endonucleolytic cleavage in its1 to separate ssu rrna from 5 8s rrna and lsu rrna from tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna", "Endonucleolytic cleavage involved in rrna processing", "Endoplasmic reticulum calcium ion homeostasis", "Endoplasmic reticulum localization", "Endoplasmic reticulum mannose trimming", "Endoplasmic reticulum membrane organization", "Endoplasmic reticulum organization", "Endoplasmic reticulum plasma membrane tethering", "Endoplasmic reticulum to cytosol transport", "Endoplasmic reticulum to golgi vesicle mediated transport", "Endoplasmic reticulum tubular network organization", "Endoplasmic reticulum unfolded protein response", "Endosomal lumen acidification", "Endosomal transport", "Endosomal vesicle fusion", "Endosome organization", "Endosome to lysosome transport", "Endosome to lysosome transport via multivesicular body sorting pathway", "Endosome to plasma membrane protein transport", "Endosome transport via multivesicular body sorting pathway", "Endothelial cell activation", "Endothelial cell apoptotic process", "Endothelial cell chemotaxis", "Endothelial cell development", "Endothelial cell fate commitment", "Endothelial cell migration", "Endothelial cell morphogenesis", "Endothelial cell proliferation", "Endothelin receptor signaling pathway", "Endothelium development", "Energy derivation by oxidation of organic compounds", "Energy homeostasis", "Energy reserve metabolic process", "Engulfment of apoptotic cell", "Ensheathment of neurons", "Enteroendocrine cell differentiation", "Entrainment of circadian clock", "Entry into host", "Entry of bacterium into host cell", "Enucleate erythrocyte differentiation", "Enzyme directed rrna pseudouridine synthesis", "Enzyme linked receptor protein signaling pathway", "Eosinophil activation", "Eosinophil chemotaxis", "Eosinophil mediated immunity", "Eosinophil migration", "Ephrin receptor signaling pathway", "Epiboly", "Epidermal cell differentiation", "Epidermis development", "Epidermis morphogenesis", "Epigenetic maintenance of chromatin in transcription competent conformation", "Epithelial cell apoptotic process", "Epithelial cell cell adhesion", "Epithelial cell development", "Epithelial cell differentiation", "Epithelial cell differentiation involved in kidney development", "Epithelial cell differentiation involved in prostate gland development", "Epithelial cell fate commitment", "Epithelial cell maturation", "Epithelial cell morphogenesis", "Epithelial cell proliferation", "Epithelial cell proliferation involved in lung morphogenesis", "Epithelial cell proliferation involved in prostate gland development", "Epithelial fluid transport", "Epithelial structure maintenance", "Epithelial to mesenchymal transition", "Epithelial to mesenchymal transition involved in endocardial cushion formation", "Epithelial tube branching involved in lung morphogenesis", "Epithelial tube formation", "Epithelial tube morphogenesis", "Epithelium development", "Epoxide metabolic process", "Er associated misfolded protein catabolic process", "Er nucleus signaling pathway", "Er overload response", "Erad pathway", "Erbb signaling pathway", "Erbb2 signaling pathway", "Erk1 and erk2 cascade", "Error free translesion synthesis", "Error prone translesion synthesis", "Erythrocyte development", "Erythrocyte homeostasis", "Erythrocyte maturation", "Escrt complex disassembly", "Establishment of cell polarity", "Establishment of centrosome localization", "Establishment of endothelial barrier", "Establishment of endothelial intestinal barrier", "Establishment of epithelial cell apical basal polarity", "Establishment of epithelial cell polarity", "Establishment of golgi localization", "Establishment of lymphocyte polarity", "Establishment of meiotic spindle localization", "Establishment of mitochondrion localization", "Establishment of mitotic spindle localization", "Establishment of organelle localization", "Establishment of pigment granule localization", "Establishment of planar polarity involved in neural tube closure", "Establishment of planar polarity of embryonic epithelium", "Establishment of protein localization", "Establishment of protein localization to chromatin", "Establishment of protein localization to chromosome", "Establishment of protein localization to endoplasmic reticulum", "Establishment of protein localization to membrane", "Establishment of protein localization to mitochondrial membrane", "Establishment of protein localization to organelle", "Establishment of protein localization to plasma membrane", "Establishment of protein localization to telomere", "Establishment of protein localization to vacuole", "Establishment of rna localization", "Establishment of sister chromatid cohesion", "Establishment of spindle orientation", "Establishment of tissue polarity", "Establishment or maintenance of bipolar cell polarity", "Establishment or maintenance of cell polarity", "Establishment or maintenance of cytoskeleton polarity", "Establishment or maintenance of monopolar cell polarity", "Establishment or maintenance of transmembrane electrochemical gradient", "Estrogen biosynthetic process", "Estrogen metabolic process", "Estrous cycle", "Ethanol catabolic process", "Ethanol metabolic process", "Ethanol oxidation", "Ethanolamine containing compound metabolic process", "Ether biosynthetic process", "Ether metabolic process", "Excitatory synapse assembly", "Excretion", "Execution phase of apoptosis", "Exit from mitosis", "Exocrine pancreas development", "Exocrine system development", "Exocyst localization", "Exocytic process", "Exocytosis", "Exonucleolytic catabolism of deadenylated mrna", "Exploration behavior", "Export across plasma membrane", "Export from cell", "External encapsulating structure organization", "Extracellular exosome assembly", "Extracellular matrix assembly", "Extracellular matrix disassembly", "Extracellular regulation of signal transduction", "Extracellular transport", "Extracellular vesicle biogenesis", "Extraembryonic membrane development", "Extrinsic apoptotic signaling pathway", "Extrinsic apoptotic signaling pathway via death domain receptors", "Eye morphogenesis", "Eye photoreceptor cell development", "Eye photoreceptor cell differentiation", "Eye pigmentation", "Eyelid development in camera type eye", "Face development", "Facial nerve morphogenesis", "Facial nerve structural organization", "Facultative heterochromatin assembly", "Farnesyl diphosphate metabolic process", "Fas signaling pathway", "Fat cell differentiation", "Fat cell proliferation", "Fat pad development", "Fat soluble vitamin metabolic process", "Fatty acid alpha oxidation", "Fatty acid beta oxidation", "Fatty acid beta oxidation using acyl coa dehydrogenase", "Fatty acid beta oxidation using acyl coa oxidase", "Fatty acid biosynthetic process", "Fatty acid catabolic process", "Fatty acid derivative biosynthetic process", "Fatty acid derivative catabolic process", "Fatty acid derivative metabolic process", "Fatty acid elongation", "Fatty acid homeostasis", "Fatty acid metabolic process", "Fatty acid omega oxidation", "Fatty acid transmembrane transport", "Fatty acid transport", "Fatty acyl coa biosynthetic process", "Fatty acyl coa catabolic process", "Fatty acyl coa metabolic process", "Fc epsilon receptor signaling pathway", "Fc gamma receptor signaling pathway", "Fc receptor mediated inhibitory signaling pathway", "Fc receptor mediated stimulatory signaling pathway", "Fc receptor signaling pathway", "Fear response", "Feeding behavior", "Female gamete generation", "Female meiosis chromosome segregation", "Female meiosis i", "Female meiotic nuclear division", "Female sex differentiation", "Fermentation", "Fertilization", "Fibroblast activation", "Fibroblast apoptotic process", "Fibroblast growth factor production", "Fibroblast growth factor receptor signaling pathway", "Fibroblast migration", "Fibroblast proliferation", "Filopodium assembly", "Flavin containing compound metabolic process", "Flavonoid metabolic process", "Fluid transport", "Foam cell differentiation", "Focal adhesion assembly", "Folate import across plasma membrane", "Folate transmembrane transport", "Folic acid containing compound biosynthetic process", "Folic acid containing compound catabolic process", "Folic acid containing compound metabolic process", "Folic acid metabolic process", "Folic acid transport", "Forebrain cell migration", "Forebrain development", "Forebrain generation of neurons", "Forebrain morphogenesis", "Forebrain neuron development", "Forebrain neuron differentiation", "Forebrain radial glial cell differentiation", "Forebrain regionalization", "Foregut morphogenesis", "Forelimb morphogenesis", "Formate metabolic process", "Formation of extrachromosomal circular dna", "Formation of primary germ layer", "Formation of translation preinitiation complex", "Free ubiquitin chain polymerization", "Fructose 1 6 bisphosphate metabolic process", "Fructose 2 6 bisphosphate metabolic process", "Fructose 6 phosphate metabolic process", "Fructose metabolic process", "Fucose metabolic process", "Fucosylation", "Fungiform papilla development", "Fungiform papilla morphogenesis", "G protein coupled acetylcholine receptor signaling pathway", "G protein coupled glutamate receptor signaling pathway", "G protein coupled opioid receptor signaling pathway", "G protein coupled purinergic receptor signaling pathway", "G protein coupled receptor internalization", "G protein coupled receptor signaling pathway", "G protein coupled receptor signaling pathway coupled to cyclic nucleotide second messenger", "G protein coupled receptor signaling pathway involved in heart process", "G quadruplex dna unwinding", "G0 to g1 transition", "G1 to g0 transition", "G2 mi transition of meiotic cell cycle", "Galactolipid biosynthetic process", "Galactolipid metabolic process", "Galactose catabolic process", "Galactose metabolic process", "Gamete generation", "Gamma aminobutyric acid metabolic process", "Gamma aminobutyric acid secretion", "Gamma aminobutyric acid signaling pathway", "Gamma aminobutyric acid transport", "Gamma delta t cell activation", "Ganglion development", "Ganglioside catabolic process", "Ganglioside metabolic process", "Gap junction assembly", "Gap junction mediated intercellular transport", "Gas homeostasis", "Gastrulation", "Gastrulation with mouth forming second", "Gdp mannose metabolic process", "Gdp metabolic process", "Gene silencing by rna", "Generation of precursor metabolites and energy", "Genitalia development", "Genitalia morphogenesis", "Genomic imprinting", "Germ cell development", "Germ cell migration", "Germ cell proliferation", "Germinal center b cell differentiation", "Germinal center formation", "Gland development", "Gland morphogenesis", "Glandular epithelial cell development", "Glandular epithelial cell differentiation", "Glial cell apoptotic process", "Glial cell development", "Glial cell differentiation", "Glial cell fate commitment", "Glial cell migration", "Glial cell proliferation", "Gliogenesis", "Glomerular basement membrane development", "Glomerular epithelial cell development", "Glomerular epithelial cell differentiation", "Glomerular epithelium development", "Glomerular visceral epithelial cell migration", "Glomerulus development", "Glomerulus morphogenesis", "Glomerulus vasculature morphogenesis", "Glucan biosynthetic process", "Glucocorticoid biosynthetic process", "Glucocorticoid metabolic process", "Glucocorticoid secretion", "Glucosamine containing compound catabolic process", "Glucosamine containing compound metabolic process", "Glucose 6 phosphate metabolic process", "Glucose catabolic process", "Glucose import", "Glucose import in response to insulin stimulus", "Glucose metabolic process", "Glucosylceramide metabolic process", "Glutamate biosynthetic process", "Glutamate catabolic process", "Glutamate homeostasis", "Glutamate metabolic process", "Glutamate receptor signaling pathway", "Glutamate reuptake", "Glutamate secretion", "Glutamate secretion neurotransmission", "Glutamine family amino acid biosynthetic process", "Glutamine family amino acid catabolic process", "Glutamine family amino acid metabolic process", "Glutamine metabolic process", "Glutamine transport", "Glutathione catabolic process", "Glutathione metabolic process", "Glycerol 3 phosphate metabolic process", "Glycerol ether metabolic process", "Glycerolipid biosynthetic process", "Glycerolipid catabolic process", "Glycerolipid metabolic process", "Glycerophospholipid biosynthetic process", "Glycerophospholipid catabolic process", "Glycerophospholipid metabolic process", "Glycine biosynthetic process", "Glycine metabolic process", "Glycolipid biosynthetic process", "Glycolipid catabolic process", "Glycolipid transport", "Glycolytic fermentation", "Glycolytic process through fructose 6 phosphate", "Glycoprotein biosynthetic process", "Glycoprotein catabolic process", "Glycoprotein metabolic process", "Glycosaminoglycan catabolic process", "Glycoside catabolic process", "Glycoside metabolic process", "Glycosphingolipid biosynthetic process", "Glycosphingolipid metabolic process", "Glycosyl compound biosynthetic process", "Glycosyl compound catabolic process", "Glycosyl compound metabolic process", "Glycosylation", "Glycosylceramide biosynthetic process", "Glycosylceramide catabolic process", "Glycosylceramide metabolic process", "Glyoxylate metabolic process", "Gmp biosynthetic process", "Gmp metabolic process", "Gmp salvage", "Golgi disassembly", "Golgi localization", "Golgi organization", "Golgi ribbon formation", "Golgi to endosome transport", "Golgi to lysosome transport", "Golgi to plasma membrane protein transport", "Golgi to plasma membrane transport", "Golgi to vacuole transport", "Golgi vesicle budding", "Golgi vesicle transport", "Gonadotropin secretion", "Gpi anchor metabolic process", "Granulocyte activation", "Granulocyte chemotaxis", "Granulocyte differentiation", "Granulocyte migration", "Granzyme mediated programmed cell death signaling pathway", "Grooming behavior", "Growth", "Growth hormone receptor signaling pathway via jak stat", "Growth hormone secretion", "Growth plate cartilage chondrocyte differentiation", "Growth plate cartilage development", "Gtp biosynthetic process", "Gtp metabolic process", "Guanine metabolic process", "Guanine nucleotide transmembrane transport", "Guanine nucleotide transport", "Hair cell differentiation", "Hair cycle phase", "Hair follicle maturation", "Hair follicle placode formation", "Hard palate development", "Head development", "Head morphogenesis", "Heart development", "Heart field specification", "Heart formation", "Heart growth", "Heart morphogenesis", "Heart process", "Heart trabecula morphogenesis", "Heart valve development", "Heart valve morphogenesis", "Heat acclimation", "Hematopoietic progenitor cell differentiation", "Hematopoietic stem cell differentiation", "Hematopoietic stem cell homeostasis", "Hematopoietic stem cell proliferation", "Heme transport", "Hemidesmosome assembly", "Hemoglobin biosynthetic process", "Hemoglobin metabolic process", "Hemostasis", "Heparan sulfate proteoglycan biosynthetic process", "Heparan sulfate proteoglycan biosynthetic process enzymatic modification", "Heparan sulfate proteoglycan biosynthetic process polysaccharide chain biosynthetic process", "Heparan sulfate proteoglycan metabolic process", "Heparin biosynthetic process", "Heparin metabolic process", "Hepatic stellate cell activation", "Hepaticobiliary system development", "Hepatocyte apoptotic process", "Hepatocyte differentiation", "Hepatocyte growth factor receptor signaling pathway", "Heterochromatin organization", "Heterophilic cell cell adhesion via plasma membrane cell adhesion molecules", "Heterotypic cell cell adhesion", "High density lipoprotein particle assembly", "High density lipoprotein particle clearance", "High density lipoprotein particle remodeling", "Hindbrain development", "Hindbrain maturation", "Hindbrain morphogenesis", "Hindbrain radial glia guided cell migration", "Hindlimb morphogenesis", "Hippo signaling", "Hippocampus development", "His purkinje system development", "Histamine production involved in inflammatory response", "Histamine secretion", "Histamine transport", "Histidine metabolic process", "Histone arginine methylation", "Histone deacetylation", "Histone dephosphorylation", "Histone deubiquitination", "Histone exchange", "Histone h2a acetylation", "Histone h2a k119 monoubiquitination", "Histone h2a k63 linked ubiquitination", "Histone h2a monoubiquitination", "Histone h2a phosphorylation", "Histone h2a ubiquitination", "Histone h2b ubiquitination", "Histone h3 acetylation", "Histone h3 deacetylation", "Histone h3 k14 acetylation", "Histone h3 k27 methylation", "Histone h3 k27 trimethylation", "Histone h3 k36 demethylation", "Histone h3 k36 methylation", "Histone h3 k36 trimethylation", "Histone h3 k4 demethylation", "Histone h3 k4 demethylation trimethyl h3 k4 specific", "Histone h3 k4 dimethylation", "Histone h3 k4 methylation", "Histone h3 k4 monomethylation", "Histone h3 k4 trimethylation", "Histone h3 k9 acetylation", "Histone h3 k9 demethylation", "Histone h3 k9 dimethylation", "Histone h3 k9 methylation", "Histone h3 k9 modification", "Histone h3 k9 trimethylation", "Histone h4 acetylation", "Histone h4 deacetylation", "Histone h4 k12 acetylation", "Histone h4 k16 acetylation", "Histone h4 k20 methylation", "Histone h4 k20 trimethylation", "Histone h4 k5 acetylation", "Histone h4 r3 methylation", "Histone lysine demethylation", "Histone methylation", "Histone modification", "Histone monoubiquitination", "Histone mrna catabolic process", "Histone mrna metabolic process", "Histone phosphorylation", "Histone serine phosphorylation", "Histone threonine phosphorylation", "Histone ubiquitination", "Homeostasis of number of cells", "Homeostasis of number of cells within a tissue", "Homeostatic process", "Homocysteine metabolic process", "Homologous chromosome pairing at meiosis", "Homologous chromosome segregation", "Homologous recombination", "Homophilic cell adhesion via plasma membrane adhesion molecules", "Homotypic cell cell adhesion", "Hormone biosynthetic process", "Hormone catabolic process", "Hormone mediated signaling pathway", "Hormone metabolic process", "Hormone transport", "Humoral immune response", "Humoral immune response mediated by circulating immunoglobulin", "Hyaluronan biosynthetic process", "Hyaluronan metabolic process", "Hydrogen peroxide biosynthetic process", "Hydrogen peroxide catabolic process", "Hydrogen peroxide metabolic process", "Hydrogen sulfide biosynthetic process", "Hydrogen sulfide metabolic process", "Hyperosmotic response", "Hyperosmotic salinity response", "Hypothalamus cell differentiation", "Hypothalamus cell migration", "Hypothalamus development", "Hypothalamus gonadotrophin releasing hormone neuron differentiation", "Hypotonic response", "Hypoxia inducible factor 1alpha signaling pathway", "I kappab kinase nf kappab signaling", "I kappab phosphorylation", "Icosanoid biosynthetic process", "Icosanoid metabolic process", "Icosanoid transport", "Immune effector process", "Immune response", "Immune response inhibiting cell surface receptor signaling pathway", "Immune response inhibiting signal transduction", "Immune response regulating cell surface receptor signaling pathway", "Immune response regulating signaling pathway", "Immune response to tumor cell", "Immune system development", "Immunoglobulin production", "Immunoglobulin production involved in immunoglobulin mediated immune response", "Immunoglobulin v d j recombination", "Immunological synapse formation", "Imp biosynthetic process", "Imp catabolic process", "Imp metabolic process", "Imp salvage", "Import across plasma membrane", "Import into cell", "Import into nucleus", "In utero embryonic development", "Inclusion body assembly", "Indolalkylamine metabolic process", "Indole containing compound biosynthetic process", "Indole containing compound metabolic process", "Inflammasome complex assembly", "Inflammatory cell apoptotic process", "Inflammatory response", "Inflammatory response to antigenic stimulus", "Inflammatory response to wounding", "Innate immune response", "Innate immune response activating signal transduction", "Innate immune response in mucosa", "Inner cell mass cell differentiation", "Inner cell mass cell proliferation", "Inner dynein arm assembly", "Inner ear auditory receptor cell differentiation", "Inner ear morphogenesis", "Inner ear receptor cell development", "Inner ear receptor cell fate commitment", "Inner ear receptor cell stereocilium organization", "Inner mitochondrial membrane organization", "Innervation", "Inorganic anion transmembrane transport", "Inorganic anion transport", "Inorganic ion import across plasma membrane", "Inorganic ion transmembrane transport", "Inosine metabolic process", "Inositol lipid mediated signaling", "Inositol metabolic process", "Inositol phosphate catabolic process", "Inositol phosphate mediated signaling", "Inositol phosphate metabolic process", "Inositol trisphosphate metabolic process", "Insulin like growth factor receptor signaling pathway", "Insulin metabolic process", "Insulin processing", "Insulin receptor signaling pathway", "Insulin secretion", "Insulin secretion involved in cellular response to glucose stimulus", "Integrated stress response signaling", "Integrin activation", "Integrin mediated signaling pathway", "Intercellular transport", "Interferon alpha production", "Interferon beta production", "Interferon gamma mediated signaling pathway", "Interferon gamma production", "Interleukin 1 alpha production", "Interleukin 1 mediated signaling pathway", "Interleukin 1 production", "Interleukin 10 production", "Interleukin 12 production", "Interleukin 13 production", "Interleukin 17 production", "Interleukin 18 production", "Interleukin 2 production", "Interleukin 23 production", "Interleukin 27 mediated signaling pathway", "Interleukin 6 mediated signaling pathway", "Interleukin 6 production", "Interleukin 8 production", "Intermediate filament based process", "Intermediate filament bundle assembly", "Intermediate filament organization", "Intermembrane lipid transfer", "Interstrand cross link repair", "Intestinal absorption", "Intestinal epithelial cell development", "Intestinal epithelial cell differentiation", "Intestinal hexose absorption", "Intestinal lipid absorption", "Intra golgi vesicle mediated transport", "Intracellular distribution of mitochondria", "Intracellular estrogen receptor signaling pathway", "Intracellular lipid transport", "Intracellular mrna localization", "Intracellular protein transmembrane transport", "Intracellular protein transport", "Intracellular receptor signaling pathway", "Intracellular sterol transport", "Intracellular transport", "Intracellular transport of virus", "Intraciliary retrograde transport", "Intraciliary transport", "Intraciliary transport involved in cilium assembly", "Intrinsic apoptotic signaling pathway", "Intrinsic apoptotic signaling pathway by p53 class mediator", "Intrinsic apoptotic signaling pathway in response to dna damage", "Intrinsic apoptotic signaling pathway in response to dna damage by p53 class mediator", "Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress", "Intrinsic apoptotic signaling pathway in response to hydrogen peroxide", "Intrinsic apoptotic signaling pathway in response to hypoxia", "Intrinsic apoptotic signaling pathway in response to osmotic stress", "Intrinsic apoptotic signaling pathway in response to oxidative stress", "Iodide transport", "Ion homeostasis", "Ion transmembrane transport", "Ion transport", "Ire1 mediated unfolded protein response", "Ires dependent viral translational initiation", "Iron coordination entity transport", "Iron import into cell", "Iron ion homeostasis", "Iron ion transmembrane transport", "Iron ion transport", "Iron sulfur cluster assembly", "Isocitrate metabolic process", "Isoleucine metabolic process", "Isopentenyl diphosphate biosynthetic process", "Isoprenoid biosynthetic process", "Isoprenoid metabolic process", "Isotype switching to iga isotypes", "Isotype switching to igg isotypes", "Jnk cascade", "Keratan sulfate metabolic process", "Keratinization", "Keratinocyte development", "Keratinocyte differentiation", "Keratinocyte migration", "Keratinocyte proliferation", "Ketone biosynthetic process", "Ketone body biosynthetic process", "Ketone body metabolic process", "Ketone catabolic process", "Kidney epithelium development", "Kidney mesenchyme development", "Kidney morphogenesis", "Killing by host of symbiont cells", "Killing of cells of another organism", "Kinetochore assembly", "Kinetochore organization", "Kynurenine metabolic process", "L alanine transport", "L alpha amino acid transmembrane transport", "L amino acid transport", "L arginine import across plasma membrane", "L arginine transmembrane transport", "L ascorbic acid metabolic process", "L aspartate transmembrane transport", "L glutamate import across plasma membrane", "L glutamate transmembrane transport", "L histidine transmembrane transport", "L kynurenine metabolic process", "L lysine transmembrane transport", "L methionine salvage from methylthioadenosine", "L phenylalanine metabolic process", "L proline biosynthetic process", "L serine biosynthetic process", "L serine catabolic process", "L serine metabolic process", "L serine transport", "Labyrinthine layer blood vessel development", "Labyrinthine layer development", "Labyrinthine layer morphogenesis", "Lacrimal gland development", "Lactate metabolic process", "Lactate transmembrane transport", "Lactation", "Lamellipodium assembly", "Lamellipodium morphogenesis", "Lamellipodium organization", "Late endosome to golgi transport", "Late endosome to lysosome transport", "Late endosome to vacuole transport", "Late endosome to vacuole transport via multivesicular body sorting pathway", "Late nucleophagy", "Lateral ventricle development", "Layer formation in cerebral cortex", "Learned vocalization behavior or vocal learning", "Learning", "Left right axis specification", "Left right pattern formation", "Lens development in camera type eye", "Lens fiber cell development", "Lens fiber cell differentiation", "Lens morphogenesis in camera type eye", "Leptin mediated signaling pathway", "Leucine catabolic process", "Leucine import across plasma membrane", "Leucine metabolic process", "Leucine transport", "Leukocyte adhesion to vascular endothelial cell", "Leukocyte aggregation", "Leukocyte apoptotic process", "Leukocyte cell cell adhesion", "Leukocyte chemotaxis", "Leukocyte degranulation", "Leukocyte differentiation", "Leukocyte homeostasis", "Leukocyte mediated cytotoxicity", "Leukocyte mediated immunity", "Leukocyte migration", "Leukocyte proliferation", "Leukocyte tethering or rolling", "Leukotriene b4 metabolic process", "Leukotriene biosynthetic process", "Leukotriene d4 metabolic process", "Leukotriene metabolic process", "Leukotriene transport", "Leydig cell differentiation", "Ligand gated ion channel signaling pathway", "Limb joint morphogenesis", "Limbic system development", "Linoleic acid metabolic process", "Lipid biosynthetic process", "Lipid catabolic process", "Lipid digestion", "Lipid droplet formation", "Lipid droplet organization", "Lipid export from cell", "Lipid glycosylation", "Lipid homeostasis", "Lipid import into cell", "Lipid localization", "Lipid metabolic process", "Lipid modification", "Lipid oxidation", "Lipid phosphorylation", "Lipid storage", "Lipid translocation", "Lipid transport across blood brain barrier", "Lipophagy", "Lipopolysaccharide mediated signaling pathway", "Lipoprotein biosynthetic process", "Lipoprotein catabolic process", "Lipoprotein localization", "Lipoprotein metabolic process", "Liposaccharide metabolic process", "Lipoxin metabolic process", "Liver morphogenesis", "Liver regeneration", "Localization within membrane", "Locomotion", "Locomotion involved in locomotory behavior", "Locomotor rhythm", "Locomotory behavior", "Locomotory exploration behavior", "Long chain fatty acid biosynthetic process", "Long chain fatty acid import across plasma membrane", "Long chain fatty acid metabolic process", "Long chain fatty acid transport", "Long chain fatty acyl coa biosynthetic process", "Long chain fatty acyl coa metabolic process", "Long term memory", "Long term synaptic depression", "Long term synaptic potentiation", "Low density lipoprotein particle clearance", "Low density lipoprotein receptor particle metabolic process", "Lung alveolus development", "Lung associated mesenchyme development", "Lung cell differentiation", "Lung epithelium development", "Lung lobe development", "Lung morphogenesis", "Lung saccule development", "Lung secretory cell differentiation", "Luteinization", "Luteolysis", "Lymph vessel development", "Lymph vessel morphogenesis", "Lymphangiogenesis", "Lymphocyte activation", "Lymphocyte activation involved in immune response", "Lymphocyte aggregation", "Lymphocyte anergy", "Lymphocyte apoptotic process", "Lymphocyte chemotaxis", "Lymphocyte costimulation", "Lymphocyte homeostasis", "Lymphocyte mediated immunity", "Lymphocyte migration", "Lymphoid progenitor cell differentiation", "Lysine catabolic process", "Lysine metabolic process", "Lysosomal lumen acidification", "Lysosomal membrane organization", "Lysosomal protein catabolic process", "Lysosomal transport", "Lytic vacuole organization", "Macroautophagy", "Macromolecule catabolic process", "Macromolecule deacylation", "Macromolecule depalmitoylation", "Macrophage activation", "Macrophage apoptotic process", "Macrophage chemotaxis", "Macrophage differentiation", "Macrophage inflammatory protein 1 alpha production", "Macrophage migration", "Macrophage proliferation", "Macropinocytosis", "Magnesium ion homeostasis", "Magnesium ion transport", "Maintenance of animal organ identity", "Maintenance of apical basal cell polarity", "Maintenance of blood brain barrier", "Maintenance of cell number", "Maintenance of cell polarity", "Maintenance of centrosome location", "Maintenance of dna methylation", "Maintenance of dna repeat elements", "Maintenance of gastrointestinal epithelium", "Maintenance of lens transparency", "Maintenance of location", "Maintenance of location in cell", "Maintenance of organelle location", "Maintenance of postsynaptic specialization structure", "Maintenance of presynaptic active zone structure", "Maintenance of protein localization in endoplasmic reticulum", "Maintenance of protein localization in organelle", "Maintenance of protein location", "Maintenance of protein location in cell", "Maintenance of protein location in mitochondrion", "Maintenance of protein location in nucleus", "Maintenance of sister chromatid cohesion", "Maintenance of synapse structure", "Malate metabolic process", "Male gamete generation", "Male genitalia development", "Male mating behavior", "Male meiosis i", "Male meiotic nuclear division", "Male sex determination", "Male sex differentiation", "Malonyl coa metabolic process", "Mammalian oogenesis stage", "Mammary gland alveolus development", "Mammary gland development", "Mammary gland duct morphogenesis", "Mammary gland epithelial cell differentiation", "Mammary gland epithelial cell proliferation", "Mammary gland epithelium development", "Mammary gland involution", "Mammary gland morphogenesis", "Manganese ion transmembrane transport", "Manganese ion transport", "Mannose metabolic process", "Mannosylation", "Mapk cascade", "Marginal zone b cell differentiation", "Mast cell activation", "Mast cell activation involved in immune response", "Mast cell cytokine production", "Mast cell proliferation", "Maternal placenta development", "Maternal process involved in female pregnancy", "Mating", "Mating behavior", "Maturation of 5 8s rrna", "Maturation of 5 8s rrna from tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna", "Maturation of lsu rrna", "Maturation of lsu rrna from tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna", "Maturation of ssu rrna", "Maturation of ssu rrna from tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna", "Mature b cell differentiation", "Mature ribosome assembly", "Mda 5 signaling pathway", "Mechanoreceptor differentiation", "Mechanosensory behavior", "Medium chain fatty acid biosynthetic process", "Medium chain fatty acid catabolic process", "Medium chain fatty acid metabolic process", "Medium chain fatty acyl coa metabolic process", "Megakaryocyte development", "Megakaryocyte differentiation", "Meiosis i cell cycle process", "Meiosis ii cell cycle process", "Meiotic cell cycle", "Meiotic cell cycle checkpoint signaling", "Meiotic cell cycle phase transition", "Meiotic cell cycle process", "Meiotic chromosome condensation", "Meiotic chromosome segregation", "Meiotic chromosome separation", "Meiotic cytokinesis", "Meiotic dna double strand break formation", "Meiotic sister chromatid cohesion centromeric", "Meiotic spindle assembly", "Meiotic spindle organization", "Melanocyte differentiation", "Melanosome assembly", "Membrane biogenesis", "Membrane depolarization", "Membrane depolarization during action potential", "Membrane depolarization during cardiac muscle cell action potential", "Membrane disassembly", "Membrane docking", "Membrane fission", "Membrane fusion", "Membrane hyperpolarization", "Membrane invagination", "Membrane lipid biosynthetic process", "Membrane lipid catabolic process", "Membrane lipid metabolic process", "Membrane organization", "Membrane protein ectodomain proteolysis", "Membrane protein intracellular domain proteolysis", "Membrane protein proteolysis", "Membrane raft assembly", "Membrane raft localization", "Membrane raft organization", "Membrane repolarization", "Membrane repolarization during action potential", "Membrane repolarization during atrial cardiac muscle cell action potential", "Membrane repolarization during cardiac muscle cell action potential", "Membrane to membrane docking", "Membranous septum morphogenesis", "Memory", "Mesangial cell development", "Mesangial cell differentiation", "Mesenchymal cell development", "Mesenchymal cell differentiation", "Mesenchymal cell differentiation involved in kidney development", "Mesenchymal cell proliferation", "Mesenchymal cell proliferation involved in lung development", "Mesenchymal stem cell differentiation", "Mesenchymal stem cell proliferation", "Mesenchymal to epithelial transition", "Mesenchymal to epithelial transition involved in metanephros morphogenesis", "Mesenchyme development", "Mesenchyme morphogenesis", "Mesoderm development", "Mesoderm morphogenesis", "Mesodermal cell differentiation", "Mesonephric duct development", "Mesonephric tubule formation", "Mesonephric tubule morphogenesis", "Mesonephros development", "Metal ion export", "Metal ion homeostasis", "Metal ion transport", "Metanephric collecting duct development", "Metanephric epithelium development", "Metanephric glomerulus development", "Metanephric glomerulus vasculature development", "Metanephric mesenchymal cell differentiation", "Metanephric mesenchyme development", "Metanephric nephron development", "Metanephric nephron morphogenesis", "Metanephric nephron tubule epithelial cell differentiation", "Metanephric part of ureteric bud development", "Metanephric renal vesicle morphogenesis", "Metanephric tubule development", "Metanephros development", "Metanephros morphogenesis", "Metaphase anaphase transition of cell cycle", "Metaphase plate congression", "Metencephalon development", "Methionine biosynthetic process", "Methionine metabolic process", "Methylation", "Methylglyoxal metabolic process", "Methylguanosine cap decapping", "Mhc class i biosynthetic process", "Mhc class ii biosynthetic process", "Microglia differentiation", "Microglial cell activation", "Microglial cell proliferation", "Microtubule anchoring", "Microtubule anchoring at centrosome", "Microtubule anchoring at microtubule organizing center", "Microtubule based movement", "Microtubule based process", "Microtubule based transport", "Microtubule bundle formation", "Microtubule cytoskeleton organization", "Microtubule cytoskeleton organization involved in mitosis", "Microtubule depolymerization", "Microtubule nucleation", "Microtubule organizing center localization", "Microtubule organizing center organization", "Microtubule polymerization", "Microtubule polymerization or depolymerization", "Microvillus assembly", "Microvillus organization", "Midbody abscission", "Midbrain development", "Midbrain dopaminergic neuron differentiation", "Middle ear morphogenesis", "Midgut development", "Minus end directed organelle transport along microtubule", "Mirna catabolic process", "Mirna loading onto risc involved in gene silencing by mirna", "Mirna metabolic process", "Mismatch repair", "Mitochondrial acetyl coa biosynthetic process from pyruvate", "Mitochondrial adp transmembrane transport", "Mitochondrial atp synthesis coupled proton transport", "Mitochondrial calcium ion homeostasis", "Mitochondrial calcium ion transmembrane transport", "Mitochondrial cytochrome c oxidase assembly", "Mitochondrial depolarization", "Mitochondrial dna metabolic process", "Mitochondrial dna repair", "Mitochondrial dna replication", "Mitochondrial electron transport cytochrome c to oxygen", "Mitochondrial electron transport nadh to ubiquinone", "Mitochondrial electron transport ubiquinol to cytochrome c", "Mitochondrial fission", "Mitochondrial fragmentation involved in apoptotic process", "Mitochondrial fusion", "Mitochondrial gene expression", "Mitochondrial genome maintenance", "Mitochondrial membrane organization", "Mitochondrial outer membrane permeabilization", "Mitochondrial outer membrane permeabilization involved in programmed cell death", "Mitochondrial protein catabolic process", "Mitochondrial protein processing", "Mitochondrial proton transporting atp synthase complex assembly", "Mitochondrial respirasome assembly", "Mitochondrial respiratory chain complex assembly", "Mitochondrial ribosome assembly", "Mitochondrial rna 3 end processing", "Mitochondrial rna catabolic process", "Mitochondrial rna metabolic process", "Mitochondrial rna modification", "Mitochondrial rna processing", "Mitochondrial transcription", "Mitochondrial translation", "Mitochondrial translational elongation", "Mitochondrial transmembrane transport", "Mitochondrial transport", "Mitochondrial trna processing", "Mitochondrion distribution", "Mitochondrion endoplasmic reticulum membrane tethering", "Mitochondrion localization", "Mitochondrion morphogenesis", "Mitochondrion organization", "Mitophagy", "Mitotic cell cycle", "Mitotic cell cycle checkpoint signaling", "Mitotic cell cycle phase transition", "Mitotic cell cycle process", "Mitotic chromosome condensation", "Mitotic cytokinesis", "Mitotic cytokinetic process", "Mitotic dna integrity checkpoint signaling", "Mitotic dna replication", "Mitotic dna replication checkpoint signaling", "Mitotic g1 s transition checkpoint signaling", "Mitotic g2 dna damage checkpoint signaling", "Mitotic g2 m transition checkpoint", "Mitotic intra s dna damage checkpoint signaling", "Mitotic metaphase plate congression", "Mitotic nuclear division", "Mitotic nuclear membrane disassembly", "Mitotic nuclear membrane organization", "Mitotic recombination", "Mitotic sister chromatid cohesion", "Mitotic sister chromatid segregation", "Mitotic spindle assembly", "Mitotic spindle midzone assembly", "Mitotic spindle organization", "Modification dependent macromolecule catabolic process", "Modification of postsynaptic actin cytoskeleton", "Modification of postsynaptic structure", "Modification of synaptic structure", "Modified amino acid transport", "Modulation by host of symbiont catalytic activity", "Modulation by host of symbiont process", "Modulation by host of viral genome replication", "Modulation by host of viral process", "Modulation of age related behavioral decline", "Modulation of excitatory postsynaptic potential", "Molting cycle", "Monoacylglycerol catabolic process", "Monoacylglycerol metabolic process", "Monoamine transport", "Monocarboxylic acid biosynthetic process", "Monocarboxylic acid catabolic process", "Monocarboxylic acid metabolic process", "Monocarboxylic acid transport", "Monocyte chemotactic protein 1 production", "Monocyte chemotaxis", "Monocyte differentiation", "Monocyte extravasation", "Mononuclear cell differentiation", "Mononuclear cell migration", "Monosaccharide biosynthetic process", "Monosaccharide catabolic process", "Monosaccharide metabolic process", "Monoubiquitinated protein deubiquitination", "Monovalent inorganic anion homeostasis", "Monovalent inorganic cation homeostasis", "Morphogenesis of a branching structure", "Morphogenesis of a polarized epithelium", "Morphogenesis of an endothelium", "Morphogenesis of an epithelial bud", "Morphogenesis of an epithelial fold", "Morphogenesis of an epithelial sheet", "Morphogenesis of an epithelium", "Morphogenesis of embryonic epithelium", "Motor behavior", "Motor learning", "Motor neuron apoptotic process", "Motor neuron axon guidance", "Motor neuron migration", "Mrna 3 end processing", "Mrna 3 end processing by stem loop binding and cleavage", "Mrna 3 splice site recognition", "Mrna 5 splice site recognition", "Mrna alternative polyadenylation", "Mrna catabolic process", "Mrna cis splicing via spliceosome", "Mrna cleavage", "Mrna cleavage involved in mrna processing", "Mrna destabilization mediated gene silencing", "Mrna export from nucleus", "Mrna metabolic process", "Mrna methylation", "Mrna modification", "Mrna processing", "Mrna pseudouridine synthesis", "Mrna splice site selection", "Mrna transcription", "Mrna transport", "Mucopolysaccharide metabolic process", "Mucosa associated lymphoid tissue development", "Mucus secretion", "Multi multicellular organism process", "Multi organism reproductive process", "Multicellular organism aging", "Multicellular organism growth", "Multicellular organism reproduction", "Multicellular organismal homeostasis", "Multicellular organismal movement", "Multicellular organismal response to stress", "Multicellular organismal signaling", "Multivesicular body organization", "Multivesicular body sorting pathway", "Muscle adaptation", "Muscle cell apoptotic process", "Muscle cell cellular homeostasis", "Muscle cell development", "Muscle cell differentiation", "Muscle cell fate commitment", "Muscle cell migration", "Muscle cell proliferation", "Muscle contraction", "Muscle hypertrophy", "Muscle hypertrophy in response to stress", "Muscle organ development", "Muscle organ morphogenesis", "Muscle structure development", "Muscle system process", "Muscle tissue development", "Myd88 dependent toll like receptor signaling pathway", "Myd88 independent toll like receptor signaling pathway", "Myelin assembly", "Myelin maintenance", "Myeloid cell activation involved in immune response", "Myeloid cell apoptotic process", "Myeloid cell development", "Myeloid cell differentiation", "Myeloid cell homeostasis", "Myeloid dendritic cell activation", "Myeloid dendritic cell cytokine production", "Myeloid dendritic cell differentiation", "Myeloid leukocyte activation", "Myeloid leukocyte cytokine production", "Myeloid leukocyte differentiation", "Myeloid leukocyte mediated immunity", "Myeloid leukocyte migration", "Myeloid progenitor cell differentiation", "Myoblast differentiation", "Myoblast fusion", "Myoblast migration", "Myofibroblast differentiation", "Myosin filament organization", "Myotube cell development", "Myotube differentiation", "N acetylglucosamine metabolic process", "N acetylneuraminate catabolic process", "N acetylneuraminate metabolic process", "N acylethanolamine metabolic process", "N glycan processing", "N terminal peptidyl methionine acetylation", "N terminal protein amino acid acetylation", "N terminal protein amino acid modification", "N terminal protein lipidation", "Nad biosynthesis via nicotinamide riboside salvage pathway", "Nad metabolic process", "Nadh dehydrogenase complex assembly", "Nadh metabolic process", "Nadh oxidation", "Nadh regeneration", "Nadp metabolic process", "Nadph regeneration", "Natural killer cell activation", "Natural killer cell activation involved in immune response", "Natural killer cell degranulation", "Natural killer cell differentiation", "Natural killer cell mediated immunity", "Ncrna 3 end processing", "Ncrna catabolic process", "Ncrna export from nucleus", "Ncrna metabolic process", "Ncrna processing", "Ncrna transcription", "Necroptotic signaling pathway", "Necrotic cell death", "Negative chemotaxis", "Negative regulation by host of viral genome replication", "Negative regulation by host of viral process", "Negative regulation by host of viral transcription", "Negative regulation of actin filament bundle assembly", "Negative regulation of actin filament depolymerization", "Negative regulation of actin filament polymerization", "Negative regulation of actin nucleation", "Negative regulation of activated t cell proliferation", "Negative regulation of activin receptor signaling pathway", "Negative regulation of adaptive immune response", "Negative regulation of adenylate cyclase activating adrenergic receptor signaling pathway", "Negative regulation of adenylate cyclase activating g protein coupled receptor signaling pathway", "Negative regulation of adenylate cyclase activity", "Negative regulation of alcohol biosynthetic process", "Negative regulation of alpha beta t cell activation", "Negative regulation of alpha beta t cell differentiation", "Negative regulation of alpha beta t cell proliferation", "Negative regulation of amine transport", "Negative regulation of amino acid transport", "Negative regulation of amyloid beta clearance", "Negative regulation of amyloid fibril formation", "Negative regulation of amyloid precursor protein biosynthetic process", "Negative regulation of amyloid precursor protein catabolic process", "Negative regulation of androgen receptor signaling pathway", "Negative regulation of anion transmembrane transport", "Negative regulation of anion transport", "Negative regulation of anoikis", "Negative regulation of antigen receptor mediated signaling pathway", "Negative regulation of apoptotic process involved in development", "Negative regulation of apoptotic signaling pathway", "Negative regulation of arp2 3 complex mediated actin nucleation", "Negative regulation of astrocyte activation", "Negative regulation of astrocyte differentiation", "Negative regulation of atp biosynthetic process", "Negative regulation of atp dependent activity", "Negative regulation of atp metabolic process", "Negative regulation of atpase coupled calcium transmembrane transporter activity", "Negative regulation of autophagosome assembly", "Negative regulation of autophagosome maturation", "Negative regulation of autophagy", "Negative regulation of autophagy of mitochondrion", "Negative regulation of axon extension", "Negative regulation of axon extension involved in axon guidance", "Negative regulation of axonogenesis", "Negative regulation of b cell activation", "Negative regulation of b cell apoptotic process", "Negative regulation of b cell differentiation", "Negative regulation of b cell mediated immunity", "Negative regulation of b cell proliferation", "Negative regulation of bicellular tight junction assembly", "Negative regulation of binding", "Negative regulation of biomineralization", "Negative regulation of biosynthetic process", "Negative regulation of blood circulation", "Negative regulation of blood pressure", "Negative regulation of blood vessel endothelial cell migration", "Negative regulation of bmp signaling pathway", "Negative regulation of bone remodeling", "Negative regulation of calcineurin mediated signaling", "Negative regulation of calcium ion dependent exocytosis", "Negative regulation of calcium ion import", "Negative regulation of calcium ion transmembrane transport", "Negative regulation of calcium ion transport", "Negative regulation of calcium ion transport into cytosol", "Negative regulation of calcium mediated signaling", "Negative regulation of camp dependent protein kinase activity", "Negative regulation of canonical wnt signaling pathway", "Negative regulation of carbohydrate metabolic process", "Negative regulation of cardiac muscle adaptation", "Negative regulation of cardiac muscle contraction", "Negative regulation of cardiac muscle tissue growth", "Negative regulation of cartilage development", "Negative regulation of catabolic process", "Negative regulation of catalytic activity", "Negative regulation of cation channel activity", "Negative regulation of cd4 positive alpha beta t cell activation", "Negative regulation of cd4 positive alpha beta t cell differentiation", "Negative regulation of cd4 positive alpha beta t cell proliferation", "Negative regulation of cell activation", "Negative regulation of cell adhesion", "Negative regulation of cell adhesion mediated by integrin", "Negative regulation of cell aging", "Negative regulation of cell cell adhesion", "Negative regulation of cell cycle", "Negative regulation of cell cycle checkpoint", "Negative regulation of cell cycle g1 s phase transition", "Negative regulation of cell cycle g2 m phase transition", "Negative regulation of cell cycle phase transition", "Negative regulation of cell cycle process", "Negative regulation of cell death", "Negative regulation of cell development", "Negative regulation of cell differentiation", "Negative regulation of cell division", "Negative regulation of cell growth", "Negative regulation of cell growth involved in cardiac muscle cell development", "Negative regulation of cell junction assembly", "Negative regulation of cell killing", "Negative regulation of cell matrix adhesion", "Negative regulation of cell morphogenesis involved in differentiation", "Negative regulation of cell population proliferation", "Negative regulation of cell projection organization", "Negative regulation of cell size", "Negative regulation of cell substrate adhesion", "Negative regulation of cell substrate junction organization", "Negative regulation of cell volume", "Negative regulation of cellular amide metabolic process", "Negative regulation of cellular amine metabolic process", "Negative regulation of cellular catabolic process", "Negative regulation of cellular component organization", "Negative regulation of cellular extravasation", "Negative regulation of cellular macromolecule biosynthetic process", "Negative regulation of cellular protein catabolic process", "Negative regulation of cellular respiration", "Negative regulation of cellular response to growth factor stimulus", "Negative regulation of cellular response to hypoxia", "Negative regulation of cellular response to insulin stimulus", "Negative regulation of cellular response to vascular endothelial growth factor stimulus", "Negative regulation of cellular senescence", "Negative regulation of centriole replication", "Negative regulation of centrosome duplication", "Negative regulation of ceramide biosynthetic process", "Negative regulation of chemokine c c motif ligand 5 production", "Negative regulation of chemokine mediated signaling pathway", "Negative regulation of chemokine production", "Negative regulation of chemotaxis", "Negative regulation of cholesterol metabolic process", "Negative regulation of chondrocyte differentiation", "Negative regulation of chromatin binding", "Negative regulation of chromatin organization", "Negative regulation of chromosome organization", "Negative regulation of cilium assembly", "Negative regulation of circadian rhythm", "Negative regulation of cold induced thermogenesis", "Negative regulation of collateral sprouting", "Negative regulation of cyclic nucleotide phosphodiesterase activity", "Negative regulation of cyclin dependent protein serine threonine kinase activity", "Negative regulation of cysteine type endopeptidase activity", "Negative regulation of cysteine type endopeptidase activity involved in apoptotic signaling pathway", "Negative regulation of cytokine production", "Negative regulation of cytokine production involved in immune response", "Negative regulation of cytokine production involved in inflammatory response", "Negative regulation of cytokinesis", "Negative regulation of cytoplasmic translation", "Negative regulation of cytoskeleton organization", "Negative regulation of cytosolic calcium ion concentration", "Negative regulation of defense response", "Negative regulation of defense response to bacterium", "Negative regulation of defense response to virus", "Negative regulation of delayed rectifier potassium channel activity", "Negative regulation of dendrite development", "Negative regulation of dendrite morphogenesis", "Negative regulation of dendritic spine development", "Negative regulation of dendritic spine morphogenesis", "Negative regulation of dephosphorylation", "Negative regulation of developmental growth", "Negative regulation of developmental process", "Negative regulation of dna binding", "Negative regulation of dna binding transcription factor activity", "Negative regulation of dna biosynthetic process", "Negative regulation of dna damage checkpoint", "Negative regulation of dna damage response signal transduction by p53 class mediator", "Negative regulation of dna dependent dna replication", "Negative regulation of dna metabolic process", "Negative regulation of dna recombination", "Negative regulation of dna repair", "Negative regulation of dna replication", "Negative regulation of dna templated transcription elongation", "Negative regulation of dna templated transcription initiation", "Negative regulation of double strand break repair via homologous recombination", "Negative regulation of double strand break repair via nonhomologous end joining", "Negative regulation of endocytosis", "Negative regulation of endoplasmic reticulum calcium ion concentration", "Negative regulation of endoplasmic reticulum stress induced eif2 alpha phosphorylation", "Negative regulation of endoplasmic reticulum stress induced intrinsic apoptotic signaling pathway", "Negative regulation of endoplasmic reticulum unfolded protein response", "Negative regulation of endothelial cell proliferation", "Negative regulation of epidermal growth factor activated receptor activity", "Negative regulation of epithelial cell apoptotic process", "Negative regulation of epithelial cell differentiation", "Negative regulation of epithelial cell migration", "Negative regulation of epithelial cell proliferation", "Negative regulation of erad pathway", "Negative regulation of erbb signaling pathway", "Negative regulation of erk1 and erk2 cascade", "Negative regulation of erythrocyte differentiation", "Negative regulation of establishment of protein localization", "Negative regulation of establishment of protein localization to mitochondrion", "Negative regulation of excitatory postsynaptic potential", "Negative regulation of execution phase of apoptosis", "Negative regulation of exocytosis", "Negative regulation of extrinsic apoptotic signaling pathway", "Negative regulation of extrinsic apoptotic signaling pathway via death domain receptors", "Negative regulation of fat cell differentiation", "Negative regulation of fatty acid beta oxidation", "Negative regulation of fatty acid biosynthetic process", "Negative regulation of fatty acid metabolic process", "Negative regulation of fatty acid oxidation", "Negative regulation of fatty acid transport", "Negative regulation of fibroblast apoptotic process", "Negative regulation of fibroblast migration", "Negative regulation of fibroblast proliferation", "Negative regulation of filopodium assembly", "Negative regulation of g protein coupled receptor signaling pathway", "Negative regulation of gene expression", "Negative regulation of gene expression epigenetic", "Negative regulation of glial cell apoptotic process", "Negative regulation of glial cell differentiation", "Negative regulation of glial cell proliferation", "Negative regulation of gliogenesis", "Negative regulation of glucocorticoid metabolic process", "Negative regulation of gluconeogenesis", "Negative regulation of glucose import", "Negative regulation of glucose transmembrane transport", "Negative regulation of glycogen metabolic process", "Negative regulation of glycolytic process", "Negative regulation of glycoprotein metabolic process", "Negative regulation of golgi to plasma membrane protein transport", "Negative regulation of granulocyte chemotaxis", "Negative regulation of granulocyte differentiation", "Negative regulation of growth", "Negative regulation of gtpase activity", "Negative regulation of guanyl nucleotide exchange factor activity", "Negative regulation of heart rate", "Negative regulation of helicase activity", "Negative regulation of hematopoietic progenitor cell differentiation", "Negative regulation of hemopoiesis", "Negative regulation of hepatocyte apoptotic process", "Negative regulation of hippo signaling", "Negative regulation of histone acetylation", "Negative regulation of histone deacetylation", "Negative regulation of histone h3 k27 methylation", "Negative regulation of histone h3 k4 methylation", "Negative regulation of histone h3 k9 methylation", "Negative regulation of histone h3 k9 trimethylation", "Negative regulation of histone h4 acetylation", "Negative regulation of histone methylation", "Negative regulation of histone modification", "Negative regulation of histone phosphorylation", "Negative regulation of homotypic cell cell adhesion", "Negative regulation of hormone biosynthetic process", "Negative regulation of hormone metabolic process", "Negative regulation of hormone secretion", "Negative regulation of hydrogen peroxide mediated programmed cell death", "Negative regulation of hydrolase activity", "Negative regulation of hypoxia induced intrinsic apoptotic signaling pathway", "Negative regulation of i kappab kinase nf kappab signaling", "Negative regulation of immune effector process", "Negative regulation of immune response", "Negative regulation of immune system process", "Negative regulation of immunoglobulin production", "Negative regulation of inclusion body assembly", "Negative regulation of inflammatory response", "Negative regulation of inflammatory response to antigenic stimulus", "Negative regulation of innate immune response", "Negative regulation of insulin secretion involved in cellular response to glucose stimulus", "Negative regulation of interferon beta production", "Negative regulation of interferon gamma production", "Negative regulation of interleukin 12 production", "Negative regulation of interleukin 13 production", "Negative regulation of interleukin 17 production", "Negative regulation of interleukin 2 production", "Negative regulation of interleukin 6 production", "Negative regulation of interleukin 8 production", "Negative regulation of intracellular estrogen receptor signaling pathway", "Negative regulation of intracellular protein transport", "Negative regulation of intracellular signal transduction", "Negative regulation of intracellular steroid hormone receptor signaling pathway", "Negative regulation of intracellular transport", "Negative regulation of intrinsic apoptotic signaling pathway", "Negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator", "Negative regulation of intrinsic apoptotic signaling pathway in response to dna damage", "Negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress", "Negative regulation of ion transmembrane transport", "Negative regulation of ion transmembrane transporter activity", "Negative regulation of ion transport", "Negative regulation of ire1 mediated unfolded protein response", "Negative regulation of isotype switching", "Negative regulation of jnk cascade", "Negative regulation of jun kinase activity", "Negative regulation of keratinocyte proliferation", "Negative regulation of kidney development", "Negative regulation of kinase activity", "Negative regulation of lamellipodium assembly", "Negative regulation of lamellipodium organization", "Negative regulation of leukocyte apoptotic process", "Negative regulation of leukocyte cell cell adhesion", "Negative regulation of leukocyte chemotaxis", "Negative regulation of leukocyte degranulation", "Negative regulation of leukocyte mediated immunity", "Negative regulation of leukocyte migration", "Negative regulation of leukocyte proliferation", "Negative regulation of lipase activity", "Negative regulation of lipid biosynthetic process", "Negative regulation of lipid catabolic process", "Negative regulation of lipid kinase activity", "Negative regulation of lipid localization", "Negative regulation of lipid metabolic process", "Negative regulation of lipid storage", "Negative regulation of lipid transport", "Negative regulation of lipopolysaccharide mediated signaling pathway", "Negative regulation of lipoprotein lipase activity", "Negative regulation of lipoprotein particle clearance", "Negative regulation of locomotion", "Negative regulation of long term synaptic potentiation", "Negative regulation of low density lipoprotein particle clearance", "Negative regulation of low density lipoprotein receptor activity", "Negative regulation of lyase activity", "Negative regulation of lymphocyte activation", "Negative regulation of lymphocyte apoptotic process", "Negative regulation of lymphocyte differentiation", "Negative regulation of lymphocyte mediated immunity", "Negative regulation of lymphocyte migration", "Negative regulation of macroautophagy", "Negative regulation of macrophage activation", "Negative regulation of macrophage chemotaxis", "Negative regulation of macrophage migration", "Negative regulation of map kinase activity", "Negative regulation of mapk cascade", "Negative regulation of mast cell activation", "Negative regulation of mast cell activation involved in immune response", "Negative regulation of mast cell degranulation", "Negative regulation of megakaryocyte differentiation", "Negative regulation of meiotic cell cycle", "Negative regulation of meiotic nuclear division", "Negative regulation of membrane depolarization", "Negative regulation of membrane permeability", "Negative regulation of membrane potential", "Negative regulation of membrane protein ectodomain proteolysis", "Negative regulation of mesenchymal cell proliferation", "Negative regulation of metalloendopeptidase activity", "Negative regulation of metallopeptidase activity", "Negative regulation of metaphase anaphase transition of cell cycle", "Negative regulation of mhc class ii biosynthetic process", "Negative regulation of microglial cell activation", "Negative regulation of microtubule polymerization", "Negative regulation of microtubule polymerization or depolymerization", "Negative regulation of mirna transcription", "Negative regulation of mitochondrial fusion", "Negative regulation of mitochondrial membrane permeability", "Negative regulation of mitochondrial membrane permeability involved in apoptotic process", "Negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway", "Negative regulation of mitochondrion organization", "Negative regulation of mitophagy", "Negative regulation of mitotic cell cycle", "Negative regulation of mitotic cell cycle phase transition", "Negative regulation of molecular function", "Negative regulation of monocyte chemotactic protein 1 production", "Negative regulation of monocyte chemotaxis", "Negative regulation of monocyte differentiation", "Negative regulation of mononuclear cell migration", "Negative regulation of monooxygenase activity", "Negative regulation of mrna 3 end processing", "Negative regulation of mrna catabolic process", "Negative regulation of mrna metabolic process", "Negative regulation of mrna processing", "Negative regulation of mrna splicing via spliceosome", "Negative regulation of multicellular organism growth", "Negative regulation of multicellular organismal process", "Negative regulation of muscle adaptation", "Negative regulation of muscle cell apoptotic process", "Negative regulation of muscle cell differentiation", "Negative regulation of muscle contraction", "Negative regulation of muscle hypertrophy", "Negative regulation of muscle organ development", "Negative regulation of muscle tissue development", "Negative regulation of myelination", "Negative regulation of myeloid cell apoptotic process", "Negative regulation of myeloid cell differentiation", "Negative regulation of myeloid leukocyte differentiation", "Negative regulation of myeloid leukocyte mediated immunity", "Negative regulation of myoblast differentiation", "Negative regulation of myosin light chain phosphatase activity", "Negative regulation of myotube differentiation", "Negative regulation of natural killer cell mediated immunity", "Negative regulation of necrotic cell death", "Negative regulation of nervous system development", "Negative regulation of nervous system process", "Negative regulation of neural precursor cell proliferation", "Negative regulation of neuroblast proliferation", "Negative regulation of neuroinflammatory response", "Negative regulation of neuron apoptotic process", "Negative regulation of neuron death", "Negative regulation of neuron differentiation", "Negative regulation of neuron migration", "Negative regulation of neuron projection development", "Negative regulation of neuron projection regeneration", "Negative regulation of neurotransmitter secretion", "Negative regulation of neurotransmitter transport", "Negative regulation of neutrophil activation", "Negative regulation of neutrophil migration", "Negative regulation of nf kappab transcription factor activity", "Negative regulation of nik nf kappab signaling", "Negative regulation of nitric oxide metabolic process", "Negative regulation of nitric oxide synthase activity", "Negative regulation of notch signaling pathway", "Negative regulation of nuclear division", "Negative regulation of nuclear transcribed mrna catabolic process deadenylation dependent decay", "Negative regulation of nuclear transcribed mrna catabolic process nonsense mediated decay", "Negative regulation of nuclease activity", "Negative regulation of nucleobase containing compound metabolic process", "Negative regulation of nucleocytoplasmic transport", "Negative regulation of nucleotide biosynthetic process", "Negative regulation of nucleotide metabolic process", "Negative regulation of oligodendrocyte differentiation", "Negative regulation of organ growth", "Negative regulation of organelle assembly", "Negative regulation of organelle organization", "Negative regulation of organic acid transport", "Negative regulation of ossification", "Negative regulation of osteoblast differentiation", "Negative regulation of osteoblast proliferation", "Negative regulation of osteoclast differentiation", "Negative regulation of oxidative phosphorylation", "Negative regulation of oxidative stress induced cell death", "Negative regulation of oxidative stress induced intrinsic apoptotic signaling pathway", "Negative regulation of oxidative stress induced neuron death", "Negative regulation of oxidative stress induced neuron intrinsic apoptotic signaling pathway", "Negative regulation of oxidoreductase activity", "Negative regulation of p38mapk cascade", "Negative regulation of pathway restricted smad protein phosphorylation", "Negative regulation of peptidase activity", "Negative regulation of peptide secretion", "Negative regulation of peptidyl cysteine s nitrosylation", "Negative regulation of peptidyl lysine acetylation", "Negative regulation of peptidyl serine phosphorylation", "Negative regulation of peptidyl threonine phosphorylation", "Negative regulation of peptidyl tyrosine phosphorylation", "Negative regulation of perk mediated unfolded protein response", "Negative regulation of phagocytosis", "Negative regulation of phosphatase activity", "Negative regulation of phosphatidylinositol 3 kinase signaling", "Negative regulation of phospholipase activity", "Negative regulation of phospholipid metabolic process", "Negative regulation of phosphoprotein phosphatase activity", "Negative regulation of phosphorus metabolic process", "Negative regulation of phosphorylation", "Negative regulation of plasma membrane bounded cell projection assembly", "Negative regulation of platelet derived growth factor receptor signaling pathway", "Negative regulation of posttranscriptional gene silencing", "Negative regulation of potassium ion transmembrane transport", "Negative regulation of potassium ion transport", "Negative regulation of production of mirnas involved in gene silencing by mirna", "Negative regulation of production of molecular mediator of immune response", "Negative regulation of programmed necrotic cell death", "Negative regulation of proteasomal protein catabolic process", "Negative regulation of proteasomal ubiquitin dependent protein catabolic process", "Negative regulation of protein acetylation", "Negative regulation of protein autophosphorylation", "Negative regulation of protein binding", "Negative regulation of protein catabolic process", "Negative regulation of protein containing complex assembly", "Negative regulation of protein containing complex disassembly", "Negative regulation of protein dephosphorylation", "Negative regulation of protein exit from endoplasmic reticulum", "Negative regulation of protein export from nucleus", "Negative regulation of protein import into nucleus", "Negative regulation of protein k63 linked ubiquitination", "Negative regulation of protein kinase activity by regulation of protein phosphorylation", "Negative regulation of protein kinase b signaling", "Negative regulation of protein localization", "Negative regulation of protein localization to cell periphery", "Negative regulation of protein localization to cell surface", "Negative regulation of protein localization to membrane", "Negative regulation of protein localization to microtubule", "Negative regulation of protein localization to nucleus", "Negative regulation of protein maturation", "Negative regulation of protein metabolic process", "Negative regulation of protein modification by small protein conjugation or removal", "Negative regulation of protein modification process", "Negative regulation of protein polymerization", "Negative regulation of protein polyubiquitination", "Negative regulation of protein secretion", "Negative regulation of protein serine threonine kinase activity", "Negative regulation of protein sumoylation", "Negative regulation of protein targeting to membrane", "Negative regulation of protein targeting to mitochondrion", "Negative regulation of protein tyrosine kinase activity", "Negative regulation of proteolysis", "Negative regulation of proteolysis involved in cellular protein catabolic process", "Negative regulation of reactive oxygen species biosynthetic process", "Negative regulation of reactive oxygen species metabolic process", "Negative regulation of receptor binding", "Negative regulation of receptor internalization", "Negative regulation of receptor mediated endocytosis", "Negative regulation of receptor recycling", "Negative regulation of receptor signaling pathway via jak stat", "Negative regulation of receptor signaling pathway via stat", "Negative regulation of regulated secretory pathway", "Negative regulation of release of cytochrome c from mitochondria", "Negative regulation of reproductive process", "Negative regulation of respiratory burst", "Negative regulation of respiratory burst involved in inflammatory response", "Negative regulation of response to biotic stimulus", "Negative regulation of response to cytokine stimulus", "Negative regulation of response to dna damage stimulus", "Negative regulation of response to endoplasmic reticulum stress", "Negative regulation of response to external stimulus", "Negative regulation of response to food", "Negative regulation of response to oxidative stress", "Negative regulation of response to reactive oxygen species", "Negative regulation of response to stimulus", "Negative regulation of response to wounding", "Negative regulation of retinoic acid receptor signaling pathway", "Negative regulation of rho protein signal transduction", "Negative regulation of rig i signaling pathway", "Negative regulation of rna catabolic process", "Negative regulation of rna splicing", "Negative regulation of ruffle assembly", "Negative regulation of ryanodine sensitive calcium release channel activity", "Negative regulation of schwann cell proliferation", "Negative regulation of secondary metabolite biosynthetic process", "Negative regulation of secretion", "Negative regulation of sequestering of triglyceride", "Negative regulation of signal transduction by p53 class mediator", "Negative regulation of signal transduction in absence of ligand", "Negative regulation of signaling", "Negative regulation of signaling receptor activity", "Negative regulation of single stranded viral rna replication via double stranded dna intermediate", "Negative regulation of sister chromatid cohesion", "Negative regulation of smad protein signal transduction", "Negative regulation of small gtpase mediated signal transduction", "Negative regulation of small molecule metabolic process", "Negative regulation of smooth muscle cell apoptotic process", "Negative regulation of smooth muscle cell differentiation", "Negative regulation of smooth muscle cell migration", "Negative regulation of smooth muscle cell proliferation", "Negative regulation of smoothened signaling pathway", "Negative regulation of smoothened signaling pathway involved in dorsal ventral neural tube patterning", "Negative regulation of sodium ion transmembrane transport", "Negative regulation of sodium ion transport", "Negative regulation of sphingolipid biosynthetic process", "Negative regulation of sprouting angiogenesis", "Negative regulation of stem cell differentiation", "Negative regulation of steroid metabolic process", "Negative regulation of stress activated protein kinase signaling cascade", "Negative regulation of striated muscle cell apoptotic process", "Negative regulation of striated muscle cell differentiation", "Negative regulation of striated muscle contraction", "Negative regulation of supramolecular fiber organization", "Negative regulation of synapse assembly", "Negative regulation of synapse organization", "Negative regulation of synaptic transmission", "Negative regulation of synaptic transmission glutamatergic", "Negative regulation of synaptic vesicle exocytosis", "Negative regulation of systemic arterial blood pressure", "Negative regulation of t cell apoptotic process", "Negative regulation of t cell differentiation", "Negative regulation of t cell proliferation", "Negative regulation of t cell receptor signaling pathway", "Negative regulation of t helper cell differentiation", "Negative regulation of telomerase activity", "Negative regulation of telomere capping", "Negative regulation of telomere maintenance", "Negative regulation of telomere maintenance via telomerase", "Negative regulation of telomere maintenance via telomere lengthening", "Negative regulation of thymocyte apoptotic process", "Negative regulation of tissue remodeling", "Negative regulation of toll like receptor 2 signaling pathway", "Negative regulation of toll like receptor 4 signaling pathway", "Negative regulation of toll like receptor signaling pathway", "Negative regulation of tor signaling", "Negative regulation of transcription by competitive promoter binding", "Negative regulation of transcription by rna polymerase i", "Negative regulation of transcription by rna polymerase ii", "Negative regulation of transcription from rna polymerase ii promoter in response to stress", "Negative regulation of transcription initiation from rna polymerase ii promoter", "Negative regulation of transcription regulatory region dna binding", "Negative regulation of transferase activity", "Negative regulation of transforming growth factor beta production", "Negative regulation of transforming growth factor beta receptor signaling pathway", "Negative regulation of transforming growth factor beta1 production", "Negative regulation of translational elongation", "Negative regulation of translational initiation", "Negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway", "Negative regulation of transmembrane transport", "Negative regulation of transport", "Negative regulation of transporter activity", "Negative regulation of trophoblast cell migration", "Negative regulation of tubulin deacetylation", "Negative regulation of tumor necrosis factor superfamily cytokine production", "Negative regulation of type 2 immune response", "Negative regulation of type b pancreatic cell apoptotic process", "Negative regulation of type i interferon mediated signaling pathway", "Negative regulation of type i interferon production", "Negative regulation of tyrosine phosphorylation of stat protein", "Negative regulation of ubiquitin dependent protein catabolic process", "Negative regulation of ubiquitin protein ligase activity", "Negative regulation of ubiquitin protein transferase activity", "Negative regulation of vascular associated smooth muscle cell apoptotic process", "Negative regulation of vascular associated smooth muscle cell differentiation", "Negative regulation of vascular associated smooth muscle cell migration", "Negative regulation of vascular associated smooth muscle cell proliferation", "Negative regulation of vascular endothelial growth factor production", "Negative regulation of vascular endothelial growth factor receptor signaling pathway", "Negative regulation of vascular permeability", "Negative regulation of vascular wound healing", "Negative regulation of vasculature development", "Negative regulation of viral entry into host cell", "Negative regulation of viral genome replication", "Negative regulation of viral induced cytoplasmic pattern recognition receptor signaling pathway", "Negative regulation of viral life cycle", "Negative regulation of viral process", "Negative regulation of viral transcription", "Negative regulation of vitamin metabolic process", "Negative regulation of voltage gated calcium channel activity", "Negative regulation of voltage gated potassium channel activity", "Negative regulation of wnt signaling pathway", "Negative regulation of wound healing", "Nephric duct development", "Nephric duct morphogenesis", "Nephron development", "Nephron epithelium development", "Nephron morphogenesis", "Nephron tubule epithelial cell differentiation", "Nephron tubule formation", "Nerve development", "Nerve growth factor signaling pathway", "Nervous system process", "Nervous system process involved in regulation of systemic arterial blood pressure", "Netrin activated signaling pathway", "Neural crest cell differentiation", "Neural crest cell migration", "Neural crest cell migration involved in autonomic nervous system development", "Neural crest formation", "Neural nucleus development", "Neural plate development", "Neural plate morphogenesis", "Neural precursor cell proliferation", "Neural retina development", "Neural tube development", "Neural tube formation", "Neural tube patterning", "Neuroblast division", "Neuroblast proliferation", "Neuroendocrine cell differentiation", "Neuroepithelial cell differentiation", "Neurofilament cytoskeleton organization", "Neurogenesis", "Neuroinflammatory response", "Neuromuscular junction development", "Neuromuscular process", "Neuromuscular process controlling balance", "Neuromuscular process controlling posture", "Neuromuscular synaptic transmission", "Neuron apoptotic process", "Neuron cellular homeostasis", "Neuron death", "Neuron death in response to hydrogen peroxide", "Neuron death in response to oxidative stress", "Neuron development", "Neuron differentiation", "Neuron fate commitment", "Neuron fate determination", "Neuron intrinsic apoptotic signaling pathway in response to oxidative stress", "Neuron maturation", "Neuron migration", "Neuron projection arborization", "Neuron projection extension", "Neuron projection extension involved in neuron projection guidance", "Neuron projection guidance", "Neuron projection maintenance", "Neuron projection organization", "Neuron projection regeneration", "Neuron recognition", "Neuron remodeling", "Neuronal action potential", "Neuronal ion channel clustering", "Neuronal stem cell population maintenance", "Neuropeptide signaling pathway", "Neurotransmitter biosynthetic process", "Neurotransmitter catabolic process", "Neurotransmitter gated ion channel clustering", "Neurotransmitter metabolic process", "Neurotransmitter receptor internalization", "Neurotransmitter receptor localization to postsynaptic specialization membrane", "Neurotransmitter receptor transport", "Neurotransmitter receptor transport endosome to postsynaptic membrane", "Neurotransmitter receptor transport postsynaptic endosome to lysosome", "Neurotransmitter receptor transport to plasma membrane", "Neurotransmitter reuptake", "Neurotransmitter secretion", "Neurotransmitter transport", "Neurotransmitter uptake", "Neurotrophin production", "Neurotrophin signaling pathway", "Neurotrophin trk receptor signaling pathway", "Neutral amino acid transport", "Neutral lipid biosynthetic process", "Neutral lipid catabolic process", "Neutral lipid metabolic process", "Neutrophil activation involved in immune response", "Neutrophil apoptotic process", "Neutrophil chemotaxis", "Neutrophil clearance", "Neutrophil degranulation", "Neutrophil differentiation", "Neutrophil homeostasis", "Neutrophil mediated immunity", "Neutrophil migration", "Nik nf kappab signaling", "Nitric oxide mediated signal transduction", "Nitric oxide synthase biosynthetic process", "Nitrogen compound transport", "Nk t cell activation", "Nk t cell differentiation", "Nls bearing protein import into nucleus", "Non canonical wnt signaling pathway", "Non lytic viral release", "Non membrane bounded organelle assembly", "Non motile cilium assembly", "Nonribosomal peptide biosynthetic process", "Norepinephrine metabolic process", "Nose development", "Notch receptor processing", "Notch signaling involved in heart development", "Notch signaling pathway", "Nuclear body organization", "Nuclear chromosome segregation", "Nuclear envelope organization", "Nuclear export", "Nuclear membrane organization", "Nuclear membrane reassembly", "Nuclear migration", "Nuclear ncrna surveillance", "Nuclear pore complex assembly", "Nuclear pore organization", "Nuclear transcribed mrna catabolic process", "Nuclear transcribed mrna catabolic process deadenylation dependent decay", "Nuclear transcribed mrna catabolic process deadenylation independent decay", "Nuclear transcribed mrna catabolic process exonucleolytic", "Nuclear transcribed mrna catabolic process exonucleolytic 3 5", "Nuclear transcribed mrna catabolic process nonsense mediated decay", "Nuclear transcribed mrna poly a tail shortening", "Nuclear transport", "Nucleic acid phosphodiester bond hydrolysis", "Nucleobase biosynthetic process", "Nucleobase catabolic process", "Nucleobase containing compound transport", "Nucleobase containing small molecule biosynthetic process", "Nucleobase containing small molecule catabolic process", "Nucleobase containing small molecule interconversion", "Nucleobase containing small molecule metabolic process", "Nucleobase metabolic process", "Nucleobase transport", "Nucleolar chromatin organization", "Nucleolar large rrna transcription by rna polymerase i", "Nucleolus organization", "Nucleoside bisphosphate biosynthetic process", "Nucleoside bisphosphate catabolic process", "Nucleoside bisphosphate metabolic process", "Nucleoside catabolic process", "Nucleoside diphosphate biosynthetic process", "Nucleoside diphosphate catabolic process", "Nucleoside diphosphate metabolic process", "Nucleoside metabolic process", "Nucleoside monophosphate biosynthetic process", "Nucleoside monophosphate catabolic process", "Nucleoside monophosphate metabolic process", "Nucleoside monophosphate phosphorylation", "Nucleoside phosphate biosynthetic process", "Nucleoside phosphate catabolic process", "Nucleoside salvage", "Nucleoside triphosphate biosynthetic process", "Nucleoside triphosphate catabolic process", "Nucleoside triphosphate metabolic process", "Nucleosome assembly", "Nucleosome mobilization", "Nucleosome organization", "Nucleosome positioning", "Nucleotide binding domain leucine rich repeat containing receptor signaling pathway", "Nucleotide binding oligomerization domain containing 2 signaling pathway", "Nucleotide excision repair", "Nucleotide excision repair dna gap filling", "Nucleotide excision repair dna incision", "Nucleotide phosphorylation", "Nucleotide salvage", "Nucleotide sugar biosynthetic process", "Nucleotide sugar metabolic process", "Nucleotide sugar transmembrane transport", "Nucleotide transmembrane transport", "Nucleotide transport", "Nucleus localization", "Nucleus organization", "O glycan processing", "Observational learning", "Odontoblast differentiation", "Odontogenesis", "Odontogenesis of dentin containing tooth", "Olefinic compound metabolic process", "Olfactory behavior", "Olfactory bulb interneuron development", "Olfactory bulb interneuron differentiation", "Olfactory lobe development", "Oligodendrocyte development", "Oligodendrocyte differentiation", "Oligodendrocyte progenitor proliferation", "Oligopeptide transport", "Oligosaccharide catabolic process", "Oligosaccharide lipid intermediate biosynthetic process", "Oligosaccharide metabolic process", "One carbon metabolic process", "Oocyte construction", "Oocyte differentiation", "Oocyte maturation", "Oogenesis", "Opsonization", "Optic nerve development", "Organ growth", "Organ induction", "Organ or tissue specific immune response", "Organelle assembly", "Organelle disassembly", "Organelle fission", "Organelle fusion", "Organelle inheritance", "Organelle localization", "Organelle membrane fusion", "Organelle transport along microtubule", "Organic acid biosynthetic process", "Organic acid catabolic process", "Organic acid metabolic process", "Organic acid transmembrane transport", "Organic acid transport", "Organic anion transport", "Organic cation transport", "Organic cyclic compound catabolic process", "Organic hydroxy compound biosynthetic process", "Organic hydroxy compound catabolic process", "Organic hydroxy compound metabolic process", "Organic hydroxy compound transport", "Organism emergence from protective structure", "Organonitrogen compound biosynthetic process", "Organonitrogen compound catabolic process", "Organophosphate biosynthetic process", "Organophosphate catabolic process", "Organophosphate ester transport", "Organophosphate metabolic process", "Ornithine metabolic process", "Ornithine transport", "Ossification", "Osteoblast differentiation", "Osteoblast proliferation", "Osteoclast development", "Osteoclast differentiation", "Outer dynein arm assembly", "Outer ear morphogenesis", "Outer mitochondrial membrane organization", "Outflow tract morphogenesis", "Outflow tract septum morphogenesis", "Ovarian follicle development", "Oviduct development", "Ovulation cycle", "Ovulation cycle process", "Oxaloacetate metabolic process", "Oxaloacetate transport", "Oxidative demethylation", "Oxidative dna demethylation", "Oxidative phosphorylation", "Oxidative rna demethylation", "Oxygen homeostasis", "P body assembly", "P38mapk cascade", "Pallium development", "Pancreas development", "Pancreatic juice secretion", "Pantothenate metabolic process", "Parallel actin filament bundle assembly", "Paranodal junction assembly", "Parasympathetic nervous system development", "Parathyroid gland development", "Paraxial mesoderm development", "Paraxial mesoderm formation", "Paraxial mesoderm morphogenesis", "Parkin mediated stimulation of mitophagy in response to mitochondrial depolarization", "Pathway restricted smad protein phosphorylation", "Pattern recognition receptor signaling pathway", "Pattern specification involved in kidney development", "Pattern specification process", "Penetration of zona pellucida", "Penile erection", "Pentose catabolic process", "Pentose metabolic process", "Pentose phosphate shunt", "Pentose phosphate shunt non oxidative branch", "Peptide antigen assembly with mhc protein complex", "Peptide biosynthetic process", "Peptide catabolic process", "Peptide cross linking", "Peptide metabolic process", "Peptide modification", "Peptide transport", "Peptidyl amino acid modification", "Peptidyl arginine methylation", "Peptidyl arginine methylation to asymmetrical dimethyl arginine", "Peptidyl arginine modification", "Peptidyl arginine n methylation", "Peptidyl asparagine modification", "Peptidyl cysteine modification", "Peptidyl diphthamide biosynthetic process from peptidyl histidine", "Peptidyl glutamic acid modification", "Peptidyl glutamine methylation", "Peptidyl histidine modification", "Peptidyl lysine acetylation", "Peptidyl lysine dimethylation", "Peptidyl lysine hydroxylation", "Peptidyl lysine methylation", "Peptidyl lysine modification", "Peptidyl lysine monomethylation", "Peptidyl lysine trimethylation", "Peptidyl methionine modification", "Peptidyl proline hydroxylation", "Peptidyl proline hydroxylation to 4 hydroxy l proline", "Peptidyl proline modification", "Peptidyl serine autophosphorylation", "Peptidyl serine dephosphorylation", "Peptidyl serine modification", "Peptidyl threonine dephosphorylation", "Peptidyl threonine modification", "Peptidyl tyrosine autophosphorylation", "Peptidyl tyrosine dephosphorylation", "Peptidyl tyrosine dephosphorylation involved in inactivation of protein kinase activity", "Peptidyl tyrosine modification", "Pericardium development", "Pericyte cell differentiation", "Peripheral nervous system axon regeneration", "Peripheral nervous system development", "Peripheral nervous system myelin maintenance", "Peristalsis", "Perk mediated unfolded protein response", "Peroxisomal transport", "Peroxisome fission", "Peroxisome organization", "Peroxisome proliferator activated receptor signaling pathway", "Ph reduction", "Phagocytosis", "Phagocytosis recognition", "Phagolysosome assembly", "Phagosome acidification", "Phagosome lysosome fusion", "Phagosome maturation", "Pharyngeal system development", "Phasic smooth muscle contraction", "Phenol containing compound biosynthetic process", "Phenol containing compound catabolic process", "Phenol containing compound metabolic process", "Phenotypic switching", "Phosphagen metabolic process", "Phosphate ion transmembrane transport", "Phosphate ion transport", "Phosphatidic acid metabolic process", "Phosphatidylcholine acyl chain remodeling", "Phosphatidylcholine biosynthetic process", "Phosphatidylcholine catabolic process", "Phosphatidylcholine metabolic process", "Phosphatidylethanolamine biosynthetic process", "Phosphatidylethanolamine metabolic process", "Phosphatidylglycerol acyl chain remodeling", "Phosphatidylglycerol biosynthetic process", "Phosphatidylglycerol metabolic process", "Phosphatidylinositol 3 kinase signaling", "Phosphatidylinositol 3 phosphate biosynthetic process", "Phosphatidylinositol acyl chain remodeling", "Phosphatidylinositol biosynthetic process", "Phosphatidylinositol dephosphorylation", "Phosphatidylinositol metabolic process", "Phosphatidylinositol phosphate biosynthetic process", "Phosphatidylserine acyl chain remodeling", "Phosphatidylserine metabolic process", "Phospholipase c activating dopamine receptor signaling pathway", "Phospholipase c activating g protein coupled receptor signaling pathway", "Phospholipid biosynthetic process", "Phospholipid catabolic process", "Phospholipid dephosphorylation", "Phospholipid homeostasis", "Phospholipid metabolic process", "Phospholipid transport", "Phosphorylation", "Phosphorylation of rna polymerase ii c terminal domain", "Photoperiodism", "Photoreceptor cell development", "Photoreceptor cell differentiation", "Photoreceptor cell maintenance", "Photoreceptor cell outer segment organization", "Phototransduction", "Phototransduction visible light", "Physiological cardiac muscle hypertrophy", "Pigment accumulation", "Pigment biosynthetic process", "Pigment cell differentiation", "Pigment granule localization", "Pigment granule maturation", "Pigment granule organization", "Pigment metabolic process", "Pigmentation", "Pinocytosis", "Pirna metabolic process", "Pituitary gland development", "Placenta blood vessel development", "Placenta development", "Planar cell polarity pathway involved in neural tube closure", "Plasma lipoprotein particle clearance", "Plasma membrane fusion", "Plasma membrane organization", "Plasma membrane phospholipid scrambling", "Plasma membrane raft assembly", "Plasma membrane raft organization", "Plasma membrane repair", "Plasma membrane to endosome transport", "Plasma membrane tubulation", "Plasminogen activation", "Platelet activating factor metabolic process", "Platelet activation", "Platelet aggregation", "Platelet degranulation", "Platelet derived growth factor receptor beta signaling pathway", "Platelet derived growth factor receptor signaling pathway", "Platelet morphogenesis", "Plus end directed organelle transport along microtubule", "Pml body organization", "Podosome assembly", "Pointed end actin filament capping", "Polarized epithelial cell differentiation", "Poly a plus mrna export from nucleus", "Poly n acetyllactosamine metabolic process", "Polyadenylation dependent rna catabolic process", "Polyadenylation dependent snorna 3 end processing", "Polyamine biosynthetic process", "Polyamine metabolic process", "Polyketide metabolic process", "Polyol biosynthetic process", "Polyol catabolic process", "Polyol metabolic process", "Polyprenol metabolic process", "Polysaccharide biosynthetic process", "Polysaccharide catabolic process", "Polysaccharide metabolic process", "Pons development", "Pore complex assembly", "Porphyrin containing compound metabolic process", "Positive chemotaxis", "Positive regulation by host of viral genome replication", "Positive regulation by host of viral process", "Positive regulation by host of viral transcription", "Positive regulation by symbiont of entry into host", "Positive regulation of 3 utr mediated mrna stabilization", "Positive regulation of actin cytoskeleton reorganization", "Positive regulation of actin filament bundle assembly", "Positive regulation of actin filament depolymerization", "Positive regulation of actin filament polymerization", "Positive regulation of actin nucleation", "Positive regulation of action potential", "Positive regulation of activated t cell proliferation", "Positive regulation of activin receptor signaling pathway", "Positive regulation of acute inflammatory response", "Positive regulation of acute inflammatory response to antigenic stimulus", "Positive regulation of adaptive immune response", "Positive regulation of adenylate cyclase activity", "Positive regulation of alcohol biosynthetic process", "Positive regulation of alpha beta t cell activation", "Positive regulation of alpha beta t cell differentiation", "Positive regulation of alpha beta t cell proliferation", "Positive regulation of amine transport", "Positive regulation of amino acid transport", "Positive regulation of amyloid beta clearance", "Positive regulation of amyloid beta formation", "Positive regulation of amyloid precursor protein biosynthetic process", "Positive regulation of amyloid precursor protein catabolic process", "Positive regulation of animal organ morphogenesis", "Positive regulation of anion transmembrane transport", "Positive regulation of anion transport", "Positive regulation of anoikis", "Positive regulation of antigen receptor mediated signaling pathway", "Positive regulation of apoptotic signaling pathway", "Positive regulation of arp2 3 complex mediated actin nucleation", "Positive regulation of aspartic type peptidase activity", "Positive regulation of astrocyte differentiation", "Positive regulation of atp biosynthetic process", "Positive regulation of atp dependent activity", "Positive regulation of atp metabolic process", "Positive regulation of atpase coupled calcium transmembrane transporter activity", "Positive regulation of attachment of spindle microtubules to kinetochore", "Positive regulation of autophagy", "Positive regulation of autophagy of mitochondrion", "Positive regulation of axon extension", "Positive regulation of axon extension involved in axon guidance", "Positive regulation of axonogenesis", "Positive regulation of b cell activation", "Positive regulation of b cell mediated immunity", "Positive regulation of b cell proliferation", "Positive regulation of b cell receptor signaling pathway", "Positive regulation of basement membrane assembly involved in embryonic body morphogenesis", "Positive regulation of behavior", "Positive regulation of binding", "Positive regulation of biomineralization", "Positive regulation of blood brain barrier permeability", "Positive regulation of blood circulation", "Positive regulation of blood pressure", "Positive regulation of blood vessel endothelial cell migration", "Positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis", "Positive regulation of bmp signaling pathway", "Positive regulation of bone mineralization", "Positive regulation of bone resorption", "Positive regulation of brown fat cell differentiation", "Positive regulation of calcineurin mediated signaling", "Positive regulation of calcium ion dependent exocytosis", "Positive regulation of calcium ion import", "Positive regulation of calcium ion transmembrane transport", "Positive regulation of calcium ion transmembrane transporter activity", "Positive regulation of calcium ion transport", "Positive regulation of calcium ion transport into cytosol", "Positive regulation of calcium mediated signaling", "Positive regulation of camp dependent protein kinase activity", "Positive regulation of camp mediated signaling", "Positive regulation of canonical wnt signaling pathway", "Positive regulation of carbohydrate metabolic process", "Positive regulation of cardiac muscle adaptation", "Positive regulation of cardiac muscle cell proliferation", "Positive regulation of cardioblast differentiation", "Positive regulation of cardiocyte differentiation", "Positive regulation of cartilage development", "Positive regulation of catabolic process", "Positive regulation of catalytic activity", "Positive regulation of catecholamine metabolic process", "Positive regulation of cation channel activity", "Positive regulation of cd4 positive alpha beta t cell activation", "Positive regulation of cd4 positive alpha beta t cell differentiation", "Positive regulation of cd8 positive alpha beta t cell activation", "Positive regulation of cell activation", "Positive regulation of cell adhesion", "Positive regulation of cell adhesion mediated by integrin", "Positive regulation of cell adhesion molecule production", "Positive regulation of cell aging", "Positive regulation of cell cell adhesion", "Positive regulation of cell cell adhesion mediated by cadherin", "Positive regulation of cell cycle", "Positive regulation of cell cycle checkpoint", "Positive regulation of cell cycle g1 s phase transition", "Positive regulation of cell cycle g2 m phase transition", "Positive regulation of cell cycle phase transition", "Positive regulation of cell cycle process", "Positive regulation of cell death", "Positive regulation of cell development", "Positive regulation of cell differentiation", "Positive regulation of cell division", "Positive regulation of cell growth", "Positive regulation of cell growth involved in cardiac muscle cell development", "Positive regulation of cell junction assembly", "Positive regulation of cell killing", "Positive regulation of cell matrix adhesion", "Positive regulation of cell maturation", "Positive regulation of cell migration by vascular endothelial growth factor signaling pathway", "Positive regulation of cell migration involved in sprouting angiogenesis", "Positive regulation of cell morphogenesis involved in differentiation", "Positive regulation of cell population proliferation", "Positive regulation of cell projection organization", "Positive regulation of cell proliferation involved in heart morphogenesis", "Positive regulation of cell size", "Positive regulation of cell substrate adhesion", "Positive regulation of cell substrate junction organization", "Positive regulation of cellular amide metabolic process", "Positive regulation of cellular amine metabolic process", "Positive regulation of cellular biosynthetic process", "Positive regulation of cellular carbohydrate metabolic process", "Positive regulation of cellular component biogenesis", "Positive regulation of cellular component organization", "Positive regulation of cellular extravasation", "Positive regulation of cellular ph reduction", "Positive regulation of cellular protein catabolic process", "Positive regulation of cellular respiration", "Positive regulation of cellular response to insulin stimulus", "Positive regulation of cellular response to transforming growth factor beta stimulus", "Positive regulation of centriole elongation", "Positive regulation of centriole replication", "Positive regulation of chemokine c c motif ligand 5 production", "Positive regulation of chemokine c x c motif ligand 2 production", "Positive regulation of chemokine production", "Positive regulation of chemotaxis", "Positive regulation of cholesterol biosynthetic process", "Positive regulation of cholesterol efflux", "Positive regulation of cholesterol metabolic process", "Positive regulation of cholesterol storage", "Positive regulation of chondrocyte differentiation", "Positive regulation of chromatin binding", "Positive regulation of chromatin organization", "Positive regulation of chromosome condensation", "Positive regulation of chromosome organization", "Positive regulation of chromosome segregation", "Positive regulation of chromosome separation", "Positive regulation of cilium assembly", "Positive regulation of circadian rhythm", "Positive regulation of clathrin dependent endocytosis", "Positive regulation of coagulation", "Positive regulation of cold induced thermogenesis", "Positive regulation of collagen metabolic process", "Positive regulation of collateral sprouting", "Positive regulation of complement activation", "Positive regulation of connective tissue replacement", "Positive regulation of cyclase activity", "Positive regulation of cyclic nucleotide phosphodiesterase activity", "Positive regulation of cyclin dependent protein kinase activity", "Positive regulation of cysteine type endopeptidase activity", "Positive regulation of cysteine type endopeptidase activity involved in apoptotic signaling pathway", "Positive regulation of cytokine production", "Positive regulation of cytokine production involved in immune response", "Positive regulation of cytokine production involved in inflammatory response", "Positive regulation of cytokinesis", "Positive regulation of cytoplasmic translation", "Positive regulation of cytoplasmic transport", "Positive regulation of cytoskeleton organization", "Positive regulation of deacetylase activity", "Positive regulation of defense response", "Positive regulation of defense response to virus by host", "Positive regulation of dendrite development", "Positive regulation of dendrite morphogenesis", "Positive regulation of dendritic cell cytokine production", "Positive regulation of dendritic cell differentiation", "Positive regulation of dendritic spine development", "Positive regulation of dendritic spine morphogenesis", "Positive regulation of deoxyribonuclease activity", "Positive regulation of dephosphorylation", "Positive regulation of developmental growth", "Positive regulation of developmental process", "Positive regulation of dna binding", "Positive regulation of dna binding transcription factor activity", "Positive regulation of dna biosynthetic process", "Positive regulation of dna damage response signal transduction by p53 class mediator", "Positive regulation of dna demethylation", "Positive regulation of dna dependent dna replication", "Positive regulation of dna ligation", "Positive regulation of dna metabolic process", "Positive regulation of dna methylation dependent heterochromatin assembly", "Positive regulation of dna recombination", "Positive regulation of dna repair", "Positive regulation of dna replication", "Positive regulation of dna templated transcription elongation", "Positive regulation of dna templated transcription initiation", "Positive regulation of dopamine receptor signaling pathway", "Positive regulation of double strand break repair", "Positive regulation of double strand break repair via homologous recombination", "Positive regulation of double strand break repair via nonhomologous end joining", "Positive regulation of early endosome to late endosome transport", "Positive regulation of embryonic development", "Positive regulation of enamel mineralization", "Positive regulation of endocytic recycling", "Positive regulation of endocytosis", "Positive regulation of endoplasmic reticulum unfolded protein response", "Positive regulation of endothelial cell apoptotic process", "Positive regulation of endothelial cell chemotaxis", "Positive regulation of endothelial cell development", "Positive regulation of endothelial cell differentiation", "Positive regulation of endothelial cell migration", "Positive regulation of endothelial cell proliferation", "Positive regulation of epidermal cell differentiation", "Positive regulation of epidermis development", "Positive regulation of epithelial cell apoptotic process", "Positive regulation of epithelial cell differentiation", "Positive regulation of epithelial cell migration", "Positive regulation of epithelial cell proliferation", "Positive regulation of epithelial cell proliferation involved in lung morphogenesis", "Positive regulation of epithelial to mesenchymal transition", "Positive regulation of er associated ubiquitin dependent protein catabolic process", "Positive regulation of erad pathway", "Positive regulation of erbb signaling pathway", "Positive regulation of erk1 and erk2 cascade", "Positive regulation of erythrocyte differentiation", "Positive regulation of establishment of protein localization", "Positive regulation of establishment of protein localization to mitochondrion", "Positive regulation of establishment of protein localization to telomere", "Positive regulation of excitatory postsynaptic potential", "Positive regulation of execution phase of apoptosis", "Positive regulation of exocytosis", "Positive regulation of exosomal secretion", "Positive regulation of extracellular matrix assembly", "Positive regulation of extracellular matrix disassembly", "Positive regulation of extracellular matrix organization", "Positive regulation of extrinsic apoptotic signaling pathway", "Positive regulation of extrinsic apoptotic signaling pathway in absence of ligand", "Positive regulation of extrinsic apoptotic signaling pathway via death domain receptors", "Positive regulation of fat cell differentiation", "Positive regulation of fatty acid beta oxidation", "Positive regulation of fatty acid biosynthetic process", "Positive regulation of fatty acid metabolic process", "Positive regulation of fatty acid oxidation", "Positive regulation of fatty acid transport", "Positive regulation of fc receptor mediated stimulatory signaling pathway", "Positive regulation of feeding behavior", "Positive regulation of fibroblast growth factor receptor signaling pathway", "Positive regulation of fibroblast migration", "Positive regulation of fibroblast proliferation", "Positive regulation of filopodium assembly", "Positive regulation of focal adhesion assembly", "Positive regulation of g protein coupled receptor signaling pathway", "Positive regulation of g0 to g1 transition", "Positive regulation of g1 s transition of mitotic cell cycle", "Positive regulation of gastrulation", "Positive regulation of gene expression", "Positive regulation of glial cell differentiation", "Positive regulation of glial cell migration", "Positive regulation of glial cell proliferation", "Positive regulation of gliogenesis", "Positive regulation of glucokinase activity", "Positive regulation of gluconeogenesis", "Positive regulation of glucose import", "Positive regulation of glucose metabolic process", "Positive regulation of glucose transmembrane transport", "Positive regulation of glutamate secretion", "Positive regulation of glycogen metabolic process", "Positive regulation of glycolytic process", "Positive regulation of glycoprotein metabolic process", "Positive regulation of golgi to plasma membrane protein transport", "Positive regulation of gonad development", "Positive regulation of granulocyte chemotaxis", "Positive regulation of granulocyte differentiation", "Positive regulation of growth", "Positive regulation of gtpase activity", "Positive regulation of hair follicle development", "Positive regulation of heart growth", "Positive regulation of heart rate", "Positive regulation of helicase activity", "Positive regulation of hematopoietic progenitor cell differentiation", "Positive regulation of hematopoietic stem cell proliferation", "Positive regulation of hemopoiesis", "Positive regulation of heterotypic cell cell adhesion", "Positive regulation of hexokinase activity", "Positive regulation of hippo signaling", "Positive regulation of histone acetylation", "Positive regulation of histone deacetylation", "Positive regulation of histone h3 k27 methylation", "Positive regulation of histone h3 k4 methylation", "Positive regulation of histone h3 k9 acetylation", "Positive regulation of histone h3 k9 methylation", "Positive regulation of histone h4 acetylation", "Positive regulation of histone methylation", "Positive regulation of histone modification", "Positive regulation of histone phosphorylation", "Positive regulation of histone ubiquitination", "Positive regulation of homotypic cell cell adhesion", "Positive regulation of hormone biosynthetic process", "Positive regulation of hormone metabolic process", "Positive regulation of hormone secretion", "Positive regulation of humoral immune response", "Positive regulation of hydrogen peroxide metabolic process", "Positive regulation of hydrolase activity", "Positive regulation of i kappab kinase nf kappab signaling", "Positive regulation of i kappab phosphorylation", "Positive regulation of immune effector process", "Positive regulation of immune response", "Positive regulation of immune system process", "Positive regulation of immunoglobulin production", "Positive regulation of inclusion body assembly", "Positive regulation of inflammatory response", "Positive regulation of inflammatory response to antigenic stimulus", "Positive regulation of innate immune response", "Positive regulation of insulin like growth factor receptor signaling pathway", "Positive regulation of insulin secretion", "Positive regulation of insulin secretion involved in cellular response to glucose stimulus", "Positive regulation of integrin activation", "Positive regulation of integrin mediated signaling pathway", "Positive regulation of interferon alpha production", "Positive regulation of interferon beta production", "Positive regulation of interferon gamma production", "Positive regulation of interleukin 1 alpha production", "Positive regulation of interleukin 1 beta production", "Positive regulation of interleukin 1 production", "Positive regulation of interleukin 10 production", "Positive regulation of interleukin 12 production", "Positive regulation of interleukin 17 production", "Positive regulation of interleukin 18 production", "Positive regulation of interleukin 2 production", "Positive regulation of interleukin 6 production", "Positive regulation of interleukin 8 production", "Positive regulation of intracellular lipid transport", "Positive regulation of intracellular protein transport", "Positive regulation of intracellular signal transduction", "Positive regulation of intracellular steroid hormone receptor signaling pathway", "Positive regulation of intracellular transport", "Positive regulation of intrinsic apoptotic signaling pathway", "Positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator", "Positive regulation of intrinsic apoptotic signaling pathway in response to dna damage", "Positive regulation of ion transmembrane transport", "Positive regulation of ion transport", "Positive regulation of ire1 mediated unfolded protein response", "Positive regulation of isotype switching", "Positive regulation of isotype switching to iga isotypes", "Positive regulation of isotype switching to igg isotypes", "Positive regulation of jnk cascade", "Positive regulation of jun kinase activity", "Positive regulation of keratinocyte differentiation", "Positive regulation of keratinocyte proliferation", "Positive regulation of kinase activity", "Positive regulation of lamellipodium assembly", "Positive regulation of lamellipodium morphogenesis", "Positive regulation of lamellipodium organization", "Positive regulation of leukocyte apoptotic process", "Positive regulation of leukocyte cell cell adhesion", "Positive regulation of leukocyte chemotaxis", "Positive regulation of leukocyte degranulation", "Positive regulation of leukocyte mediated immunity", "Positive regulation of leukocyte migration", "Positive regulation of leukocyte proliferation", "Positive regulation of ligase activity", "Positive regulation of lipase activity", "Positive regulation of lipid biosynthetic process", "Positive regulation of lipid catabolic process", "Positive regulation of lipid kinase activity", "Positive regulation of lipid localization", "Positive regulation of lipid metabolic process", "Positive regulation of lipid storage", "Positive regulation of lipid transport", "Positive regulation of lipopolysaccharide mediated signaling pathway", "Positive regulation of lipoprotein particle clearance", "Positive regulation of locomotion", "Positive regulation of long term synaptic depression", "Positive regulation of long term synaptic potentiation", "Positive regulation of low density lipoprotein receptor activity", "Positive regulation of lyase activity", "Positive regulation of lymphocyte anergy", "Positive regulation of lymphocyte apoptotic process", "Positive regulation of lymphocyte chemotaxis", "Positive regulation of lymphocyte differentiation", "Positive regulation of lymphocyte mediated immunity", "Positive regulation of lymphocyte migration", "Positive regulation of macroautophagy", "Positive regulation of macrophage activation", "Positive regulation of macrophage chemotaxis", "Positive regulation of macrophage differentiation", "Positive regulation of macrophage migration", "Positive regulation of maintenance of sister chromatid cohesion", "Positive regulation of mammary gland epithelial cell proliferation", "Positive regulation of map kinase activity", "Positive regulation of mapk cascade", "Positive regulation of mast cell activation", "Positive regulation of mast cell activation involved in immune response", "Positive regulation of megakaryocyte differentiation", "Positive regulation of meiotic cell cycle", "Positive regulation of membrane depolarization", "Positive regulation of membrane permeability", "Positive regulation of membrane potential", "Positive regulation of membrane protein ectodomain proteolysis", "Positive regulation of mesenchymal cell proliferation", "Positive regulation of mesenchymal stem cell proliferation", "Positive regulation of metalloendopeptidase activity", "Positive regulation of metallopeptidase activity", "Positive regulation of metaphase anaphase transition of cell cycle", "Positive regulation of mhc class i biosynthetic process", "Positive regulation of microglial cell activation", "Positive regulation of microtubule binding", "Positive regulation of microtubule nucleation", "Positive regulation of microtubule polymerization or depolymerization", "Positive regulation of mirna catabolic process", "Positive regulation of mirna mediated gene silencing by inhibition of translation", "Positive regulation of mirna metabolic process", "Positive regulation of mirna transcription", "Positive regulation of mitochondrial calcium ion concentration", "Positive regulation of mitochondrial depolarization", "Positive regulation of mitochondrial fission", "Positive regulation of mitochondrial membrane potential", "Positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway", "Positive regulation of mitochondrial translation", "Positive regulation of mitochondrion organization", "Positive regulation of mitophagy", "Positive regulation of mitophagy in response to mitochondrial depolarization", "Positive regulation of mitotic cell cycle", "Positive regulation of mitotic cell cycle phase transition", "Positive regulation of mitotic cell cycle spindle assembly checkpoint", "Positive regulation of mitotic nuclear division", "Positive regulation of molecular function", "Positive regulation of monocyte chemotaxis", "Positive regulation of monocyte differentiation", "Positive regulation of mononuclear cell migration", "Positive regulation of monooxygenase activity", "Positive regulation of morphogenesis of an epithelium", "Positive regulation of mrna 3 end processing", "Positive regulation of mrna metabolic process", "Positive regulation of mrna processing", "Positive regulation of mrna splicing via spliceosome", "Positive regulation of multicellular organism growth", "Positive regulation of multicellular organismal process", "Positive regulation of muscle adaptation", "Positive regulation of muscle cell apoptotic process", "Positive regulation of muscle cell differentiation", "Positive regulation of muscle contraction", "Positive regulation of muscle hypertrophy", "Positive regulation of muscle tissue development", "Positive regulation of myelination", "Positive regulation of myeloid cell apoptotic process", "Positive regulation of myeloid cell differentiation", "Positive regulation of myeloid leukocyte cytokine production involved in immune response", "Positive regulation of myeloid leukocyte differentiation", "Positive regulation of myeloid leukocyte mediated immunity", "Positive regulation of myoblast differentiation", "Positive regulation of myoblast fusion", "Positive regulation of myotube differentiation", "Positive regulation of nad p h oxidase activity", "Positive regulation of natural killer cell activation", "Positive regulation of natural killer cell mediated cytotoxicity", "Positive regulation of natural killer cell mediated immunity", "Positive regulation of necrotic cell death", "Positive regulation of nervous system development", "Positive regulation of nervous system process", "Positive regulation of neural precursor cell proliferation", "Positive regulation of neuroblast proliferation", "Positive regulation of neurogenesis", "Positive regulation of neuroinflammatory response", "Positive regulation of neuron apoptotic process", "Positive regulation of neuron death", "Positive regulation of neuron differentiation", "Positive regulation of neuron migration", "Positive regulation of neuron projection arborization", "Positive regulation of neuron projection development", "Positive regulation of neuron projection regeneration", "Positive regulation of neurotransmitter secretion", "Positive regulation of neurotransmitter transport", "Positive regulation of neurotransmitter uptake", "Positive regulation of neurotrophin trk receptor signaling pathway", "Positive regulation of neutrophil migration", "Positive regulation of nf kappab transcription factor activity", "Positive regulation of nik nf kappab signaling", "Positive regulation of nitric oxide metabolic process", "Positive regulation of nitric oxide synthase activity", "Positive regulation of nitric oxide synthase biosynthetic process", "Positive regulation of nk t cell activation", "Positive regulation of nlrp3 inflammasome complex assembly", "Positive regulation of non motile cilium assembly", "Positive regulation of notch signaling pathway", "Positive regulation of nuclear cell cycle dna replication", "Positive regulation of nuclear division", "Positive regulation of nuclear transcribed mrna catabolic process deadenylation dependent decay", "Positive regulation of nuclease activity", "Positive regulation of nucleobase containing compound metabolic process", "Positive regulation of nucleobase containing compound transport", "Positive regulation of nucleocytoplasmic transport", "Positive regulation of nucleotide binding oligomerization domain containing 2 signaling pathway", "Positive regulation of nucleotide binding oligomerization domain containing signaling pathway", "Positive regulation of nucleotide biosynthetic process", "Positive regulation of nucleotide metabolic process", "Positive regulation of oligodendrocyte differentiation", "Positive regulation of opsonization", "Positive regulation of organ growth", "Positive regulation of organelle assembly", "Positive regulation of organelle organization", "Positive regulation of organic acid transport", "Positive regulation of ossification", "Positive regulation of osteoblast differentiation", "Positive regulation of osteoclast differentiation", "Positive regulation of oxidative stress induced cell death", "Positive regulation of oxidative stress induced intrinsic apoptotic signaling pathway", "Positive regulation of oxidative stress induced neuron death", "Positive regulation of oxidoreductase activity", "Positive regulation of p38mapk cascade", "Positive regulation of pathway restricted smad protein phosphorylation", "Positive regulation of pattern recognition receptor signaling pathway", "Positive regulation of peptidase activity", "Positive regulation of peptide secretion", "Positive regulation of peptidyl lysine acetylation", "Positive regulation of peptidyl serine phosphorylation", "Positive regulation of peptidyl threonine phosphorylation", "Positive regulation of peptidyl tyrosine phosphorylation", "Positive regulation of phagocytosis", "Positive regulation of phosphatase activity", "Positive regulation of phosphatidylinositol 3 kinase signaling", "Positive regulation of phospholipase a2 activity", "Positive regulation of phospholipase activity", "Positive regulation of phospholipid biosynthetic process", "Positive regulation of phospholipid metabolic process", "Positive regulation of phosphoprotein phosphatase activity", "Positive regulation of phosphorus metabolic process", "Positive regulation of pinocytosis", "Positive regulation of plasma membrane bounded cell projection assembly", "Positive regulation of plasminogen activation", "Positive regulation of platelet aggregation", "Positive regulation of platelet derived growth factor receptor signaling pathway", "Positive regulation of podosome assembly", "Positive regulation of posttranscriptional gene silencing", "Positive regulation of potassium ion import across plasma membrane", "Positive regulation of potassium ion transmembrane transporter activity", "Positive regulation of potassium ion transport", "Positive regulation of production of mirnas involved in gene silencing by mirna", "Positive regulation of production of molecular mediator of immune response", "Positive regulation of programmed necrotic cell death", "Positive regulation of prostaglandin biosynthetic process", "Positive regulation of proteasomal ubiquitin dependent protein catabolic process", "Positive regulation of protein acetylation", "Positive regulation of protein autophosphorylation", "Positive regulation of protein binding", "Positive regulation of protein catabolic process", "Positive regulation of protein catabolic process in the vacuole", "Positive regulation of protein containing complex assembly", "Positive regulation of protein containing complex disassembly", "Positive regulation of protein deacetylation", "Positive regulation of protein dephosphorylation", "Positive regulation of protein depolymerization", "Positive regulation of protein deubiquitination", "Positive regulation of protein exit from endoplasmic reticulum", "Positive regulation of protein export from nucleus", "Positive regulation of protein glycosylation", "Positive regulation of protein import", "Positive regulation of protein k63 linked ubiquitination", "Positive regulation of protein kinase a signaling", "Positive regulation of protein kinase activity", "Positive regulation of protein kinase b signaling", "Positive regulation of protein localization", "Positive regulation of protein localization to cell cortex", "Positive regulation of protein localization to cell periphery", "Positive regulation of protein localization to cell surface", "Positive regulation of protein localization to centrosome", "Positive regulation of protein localization to cilium", "Positive regulation of protein localization to early endosome", "Positive regulation of protein localization to membrane", "Positive regulation of protein localization to nucleus", "Positive regulation of protein maturation", "Positive regulation of protein metabolic process", "Positive regulation of protein modification by small protein conjugation or removal", "Positive regulation of protein modification process", "Positive regulation of protein monoubiquitination", "Positive regulation of protein neddylation", "Positive regulation of protein phosphorylation", "Positive regulation of protein polymerization", "Positive regulation of protein polyubiquitination", "Positive regulation of protein secretion", "Positive regulation of protein serine threonine kinase activity", "Positive regulation of protein sumoylation", "Positive regulation of protein targeting to membrane", "Positive regulation of protein tyrosine kinase activity", "Positive regulation of proteolysis", "Positive regulation of proteolysis involved in cellular protein catabolic process", "Positive regulation of pseudopodium assembly", "Positive regulation of reactive oxygen species biosynthetic process", "Positive regulation of reactive oxygen species metabolic process", "Positive regulation of receptor binding", "Positive regulation of receptor catabolic process", "Positive regulation of receptor clustering", "Positive regulation of receptor internalization", "Positive regulation of receptor mediated endocytosis", "Positive regulation of receptor recycling", "Positive regulation of receptor signaling pathway via stat", "Positive regulation of regulated secretory pathway", "Positive regulation of release of cytochrome c from mitochondria", "Positive regulation of release of sequestered calcium ion into cytosol", "Positive regulation of renal sodium excretion", "Positive regulation of reproductive process", "Positive regulation of respiratory burst", "Positive regulation of response to biotic stimulus", "Positive regulation of response to cytokine stimulus", "Positive regulation of response to dna damage stimulus", "Positive regulation of response to endoplasmic reticulum stress", "Positive regulation of response to external stimulus", "Positive regulation of response to oxidative stress", "Positive regulation of response to reactive oxygen species", "Positive regulation of response to tumor cell", "Positive regulation of response to wounding", "Positive regulation of retinoic acid receptor signaling pathway", "Positive regulation of rho protein signal transduction", "Positive regulation of rig i signaling pathway", "Positive regulation of rna binding", "Positive regulation of rna export from nucleus", "Positive regulation of rna metabolic process", "Positive regulation of rna polymerase ii transcription preinitiation complex assembly", "Positive regulation of rna splicing", "Positive regulation of rrna processing", "Positive regulation of ruffle assembly", "Positive regulation of ryanodine sensitive calcium release channel activity", "Positive regulation of secondary metabolite biosynthetic process", "Positive regulation of secretion", "Positive regulation of sequestering of calcium ion", "Positive regulation of sequestering of triglyceride", "Positive regulation of signal transduction by p53 class mediator", "Positive regulation of signaling", "Positive regulation of signaling receptor activity", "Positive regulation of sister chromatid cohesion", "Positive regulation of skeletal muscle fiber development", "Positive regulation of skeletal muscle tissue development", "Positive regulation of smad protein signal transduction", "Positive regulation of small gtpase mediated signal transduction", "Positive regulation of small molecule metabolic process", "Positive regulation of smooth muscle cell apoptotic process", "Positive regulation of smooth muscle cell differentiation", "Positive regulation of smooth muscle cell migration", "Positive regulation of smooth muscle cell proliferation", "Positive regulation of smooth muscle contraction", "Positive regulation of smoothened signaling pathway", "Positive regulation of sodium ion transmembrane transport", "Positive regulation of sodium ion transmembrane transporter activity", "Positive regulation of sodium ion transport", "Positive regulation of spindle assembly", "Positive regulation of sprouting angiogenesis", "Positive regulation of stem cell differentiation", "Positive regulation of stem cell proliferation", "Positive regulation of steroid biosynthetic process", "Positive regulation of steroid hormone biosynthetic process", "Positive regulation of steroid metabolic process", "Positive regulation of sterol transport", "Positive regulation of stress activated protein kinase signaling cascade", "Positive regulation of stress fiber assembly", "Positive regulation of striated muscle cell apoptotic process", "Positive regulation of striated muscle cell differentiation", "Positive regulation of striated muscle contraction", "Positive regulation of substrate adhesion dependent cell spreading", "Positive regulation of supramolecular fiber organization", "Positive regulation of synapse assembly", "Positive regulation of synapse maturation", "Positive regulation of synaptic plasticity", "Positive regulation of synaptic transmission", "Positive regulation of synaptic transmission gabaergic", "Positive regulation of synaptic transmission glutamatergic", "Positive regulation of synaptic vesicle endocytosis", "Positive regulation of synaptic vesicle exocytosis", "Positive regulation of synaptic vesicle recycling", "Positive regulation of syncytium formation by plasma membrane fusion", "Positive regulation of t cell apoptotic process", "Positive regulation of t cell cytokine production", "Positive regulation of t cell differentiation in thymus", "Positive regulation of t cell mediated cytotoxicity", "Positive regulation of t cell mediated immune response to tumor cell", "Positive regulation of t cell mediated immunity", "Positive regulation of t cell migration", "Positive regulation of t cell proliferation", "Positive regulation of t cell receptor signaling pathway", "Positive regulation of t cell tolerance induction", "Positive regulation of t helper 1 cell differentiation", "Positive regulation of t helper 17 cell differentiation", "Positive regulation of t helper 17 type immune response", "Positive regulation of t helper cell differentiation", "Positive regulation of tau protein kinase activity", "Positive regulation of telomerase activity", "Positive regulation of telomerase rna localization to cajal body", "Positive regulation of telomere capping", "Positive regulation of telomere maintenance", "Positive regulation of telomere maintenance via telomere lengthening", "Positive regulation of tissue remodeling", "Positive regulation of tolerance induction", "Positive regulation of toll like receptor 3 signaling pathway", "Positive regulation of toll like receptor 9 signaling pathway", "Positive regulation of toll like receptor signaling pathway", "Positive regulation of tooth mineralization", "Positive regulation of tor signaling", "Positive regulation of torc1 signaling", "Positive regulation of transcription by rna polymerase i", "Positive regulation of transcription by rna polymerase ii", "Positive regulation of transcription by rna polymerase iii", "Positive regulation of transcription elongation from rna polymerase ii promoter", "Positive regulation of transcription from rna polymerase ii promoter in response to endoplasmic reticulum stress", "Positive regulation of transcription from rna polymerase ii promoter in response to hypoxia", "Positive regulation of transcription from rna polymerase ii promoter in response to stress", "Positive regulation of transcription from rna polymerase ii promoter involved in cellular response to chemical stimulus", "Positive regulation of transcription of notch receptor target", "Positive regulation of transcription of nucleolar large rrna by rna polymerase i", "Positive regulation of transcription regulatory region dna binding", "Positive regulation of transferase activity", "Positive regulation of transforming growth factor beta production", "Positive regulation of transforming growth factor beta1 production", "Positive regulation of translation", "Positive regulation of translation in response to endoplasmic reticulum stress", "Positive regulation of translation in response to stress", "Positive regulation of translational initiation", "Positive regulation of transmembrane receptor protein serine threonine kinase signaling pathway", "Positive regulation of transmembrane transport", "Positive regulation of transmission of nerve impulse", "Positive regulation of transport", "Positive regulation of transporter activity", "Positive regulation of triglyceride biosynthetic process", "Positive regulation of triglyceride catabolic process", "Positive regulation of triglyceride metabolic process", "Positive regulation of trophoblast cell migration", "Positive regulation of tumor necrosis factor mediated signaling pathway", "Positive regulation of tumor necrosis factor superfamily cytokine production", "Positive regulation of type i interferon mediated signaling pathway", "Positive regulation of type i interferon production", "Positive regulation of tyrosine phosphorylation of stat protein", "Positive regulation of ubiquitin dependent protein catabolic process", "Positive regulation of ubiquitin protein ligase activity", "Positive regulation of ubiquitin protein transferase activity", "Positive regulation of unsaturated fatty acid biosynthetic process", "Positive regulation of urine volume", "Positive regulation of vacuole organization", "Positive regulation of vascular associated smooth muscle cell apoptotic process", "Positive regulation of vascular associated smooth muscle cell differentiation", "Positive regulation of vascular associated smooth muscle cell migration", "Positive regulation of vascular associated smooth muscle cell proliferation", "Positive regulation of vascular endothelial cell proliferation", "Positive regulation of vascular endothelial growth factor production", "Positive regulation of vascular endothelial growth factor receptor signaling pathway", "Positive regulation of vascular endothelial growth factor signaling pathway", "Positive regulation of vascular permeability", "Positive regulation of vasculature development", "Positive regulation of vasculogenesis", "Positive regulation of vesicle fusion", "Positive regulation of viral genome replication", "Positive regulation of viral life cycle", "Positive regulation of viral process", "Positive regulation of vitamin d receptor signaling pathway", "Positive regulation of voltage gated calcium channel activity", "Positive regulation of wnt signaling pathway", "Positive regulation of wound healing", "Positive regulation of wound healing spreading of epidermal cells", "Positive t cell selection", "Post anal tail morphogenesis", "Post chaperonin tubulin folding pathway", "Post embryonic development", "Post golgi vesicle mediated transport", "Post translational protein modification", "Postreplication repair", "Postsynapse assembly", "Postsynapse organization", "Postsynapse to nucleus signaling pathway", "Postsynaptic actin cytoskeleton organization", "Postsynaptic cytoskeleton organization", "Postsynaptic density protein 95 clustering", "Postsynaptic membrane assembly", "Postsynaptic membrane organization", "Postsynaptic modulation of chemical synaptic transmission", "Postsynaptic neurotransmitter receptor internalization", "Postsynaptic signal transduction", "Postsynaptic specialization organization", "Posttranscriptional regulation of gene expression", "Posttranslational protein targeting to endoplasmic reticulum membrane", "Posttranslational protein targeting to membrane translocation", "Potassium ion export across plasma membrane", "Potassium ion homeostasis", "Potassium ion import across plasma membrane", "Potassium ion transport", "Pre mirna processing", "Preassembly of gpi anchor in er membrane", "Prenylation", "Prepulse inhibition", "Presynapse organization", "Presynaptic active zone organization", "Presynaptic endocytosis", "Presynaptic modulation of chemical synaptic transmission", "Prevention of polyspermy", "Primary alcohol biosynthetic process", "Primary alcohol catabolic process", "Primary alcohol metabolic process", "Primary amino compound biosynthetic process", "Primary amino compound metabolic process", "Primary mirna processing", "Primitive hemopoiesis", "Pro b cell differentiation", "Process utilizing autophagic mechanism", "Production of molecular mediator involved in inflammatory response", "Production of molecular mediator of immune response", "Production of sirna involved in rna interference", "Progesterone receptor signaling pathway", "Programmed cell death", "Programmed cell death in response to reactive oxygen species", "Programmed cell death involved in cell development", "Programmed necrotic cell death", "Prolactin secretion", "Proline metabolic process", "Pronephros development", "Proprioception", "Prostaglandin transport", "Prostanoid biosynthetic process", "Prostanoid metabolic process", "Prostate gland development", "Prostate gland growth", "Prosthetic group metabolic process", "Proteasomal protein catabolic process", "Proteasome assembly", "Proteasome mediated ubiquitin dependent protein catabolic process", "Protection from natural killer cell mediated cytotoxicity", "Protection from non homologous end joining at telomere", "Protein acetylation", "Protein activation cascade", "Protein acylation", "Protein adp ribosylation", "Protein auto adp ribosylation", "Protein autophosphorylation", "Protein autoprocessing", "Protein autoubiquitination", "Protein catabolic process", "Protein catabolic process in the vacuole", "Protein complex oligomerization", "Protein containing complex disassembly", "Protein containing complex localization", "Protein containing complex organization", "Protein containing complex remodeling", "Protein de adp ribosylation", "Protein deglycosylation", "Protein demannosylation", "Protein demethylation", "Protein deneddylation", "Protein depalmitoylation", "Protein dephosphorylation", "Protein depolymerization", "Protein destabilization", "Protein desumoylation", "Protein deubiquitination involved in ubiquitin dependent protein catabolic process", "Protein dna complex assembly", "Protein dna complex disassembly", "Protein dna complex subunit organization", "Protein dna covalent cross linking repair", "Protein exit from endoplasmic reticulum", "Protein export from nucleus", "Protein folding", "Protein folding in endoplasmic reticulum", "Protein geranylgeranylation", "Protein heterooligomerization", "Protein heterotetramerization", "Protein hexamerization", "Protein homooligomerization", "Protein homotetramerization", "Protein hydroxylation", "Protein import", "Protein import into mitochondrial matrix", "Protein import into peroxisome matrix", "Protein import into peroxisome membrane", "Protein insertion into er membrane", "Protein insertion into er membrane by stop transfer membrane anchor sequence", "Protein insertion into membrane", "Protein insertion into mitochondrial inner membrane", "Protein insertion into mitochondrial membrane involved in apoptotic signaling pathway", "Protein k11 linked deubiquitination", "Protein k11 linked ubiquitination", "Protein k27 linked ubiquitination", "Protein k29 linked deubiquitination", "Protein k29 linked ubiquitination", "Protein k48 linked deubiquitination", "Protein k48 linked ubiquitination", "Protein k6 linked ubiquitination", "Protein k63 linked deubiquitination", "Protein k63 linked ubiquitination", "Protein kinase a signaling", "Protein kinase b signaling", "Protein kinase c activating g protein coupled receptor signaling pathway", "Protein kinase c signaling", "Protein lipid complex assembly", "Protein lipid complex subunit organization", "Protein localization to adherens junction", "Protein localization to axon", "Protein localization to basolateral plasma membrane", "Protein localization to cell cell junction", "Protein localization to cell cortex", "Protein localization to cell junction", "Protein localization to cell periphery", "Protein localization to cell surface", "Protein localization to chromatin", "Protein localization to chromosome", "Protein localization to chromosome centromeric region", "Protein localization to chromosome telomeric region", "Protein localization to ciliary membrane", "Protein localization to cilium", "Protein localization to condensed chromosome", "Protein localization to cytoplasmic stress granule", "Protein localization to cytoskeleton", "Protein localization to early endosome", "Protein localization to endoplasmic reticulum", "Protein localization to endoplasmic reticulum exit site", "Protein localization to endosome", "Protein localization to extracellular region", "Protein localization to golgi apparatus", "Protein localization to lysosome", "Protein localization to membrane raft", "Protein localization to microtubule", "Protein localization to microtubule end", "Protein localization to microtubule organizing center", "Protein localization to mitochondrion", "Protein localization to nuclear body", "Protein localization to nuclear envelope", "Protein localization to nucleolus", "Protein localization to nucleoplasm", "Protein localization to nucleus", "Protein localization to organelle", "Protein localization to perinuclear region of cytoplasm", "Protein localization to phagophore assembly site", "Protein localization to plasma membrane", "Protein localization to postsynapse", "Protein localization to presynapse", "Protein localization to synapse", "Protein localization to vacuole", "Protein mannosylation", "Protein maturation", "Protein maturation by 4fe 4s cluster transfer", "Protein maturation by iron sulfur cluster transfer", "Protein maturation by protein folding", "Protein methylation", "Protein modification by small protein conjugation", "Protein modification by small protein conjugation or removal", "Protein modification by small protein removal", "Protein monoubiquitination", "Protein n linked glycosylation", "Protein neddylation", "Protein nitrosylation", "Protein o linked fucosylation", "Protein o linked glycosylation", "Protein o linked glycosylation via serine", "Protein o linked glycosylation via threonine", "Protein o linked mannosylation", "Protein oxidation", "Protein peptidyl prolyl isomerization", "Protein poly adp ribosylation", "Protein polyglutamylation", "Protein polymerization", "Protein polyubiquitination", "Protein polyufmylation", "Protein processing", "Protein processing involved in protein targeting to mitochondrion", "Protein quality control for misfolded or incompletely synthesized proteins", "Protein refolding", "Protein repair", "Protein retention in er lumen", "Protein retention in golgi apparatus", "Protein stabilization", "Protein sumoylation", "Protein targeting", "Protein targeting to lysosome", "Protein targeting to membrane", "Protein targeting to mitochondrion", "Protein targeting to peroxisome", "Protein targeting to vacuole", "Protein tetramerization", "Protein transmembrane import into intracellular organelle", "Protein transmembrane transport", "Protein transport along microtubule", "Protein transport to vacuole involved in ubiquitin dependent protein catabolic process via the multivesicular body sorting pathway", "Protein transport within lipid bilayer", "Protein trimerization", "Protein ufmylation", "Proteoglycan biosynthetic process", "Proteoglycan metabolic process", "Proteolysis", "Proton transmembrane transport", "Proton transporting two sector atpase complex assembly", "Proton transporting v type atpase complex assembly", "Protoporphyrinogen ix biosynthetic process", "Protoporphyrinogen ix metabolic process", "Proximal distal pattern formation", "Proximal distal pattern formation involved in nephron development", "Proximal tubule development", "Pseudopodium organization", "Pseudouridine synthesis", "Pteridine containing compound biosynthetic process", "Pteridine containing compound metabolic process", "Pulmonary artery morphogenesis", "Pulmonary valve development", "Pulmonary valve morphogenesis", "Purine containing compound biosynthetic process", "Purine containing compound catabolic process", "Purine containing compound metabolic process", "Purine containing compound salvage", "Purine containing compound transmembrane transport", "Purine deoxyribonucleoside metabolic process", "Purine deoxyribonucleoside monophosphate catabolic process", "Purine deoxyribonucleoside monophosphate metabolic process", "Purine deoxyribonucleoside triphosphate metabolic process", "Purine deoxyribonucleotide biosynthetic process", "Purine deoxyribonucleotide catabolic process", "Purine deoxyribonucleotide metabolic process", "Purine nucleobase biosynthetic process", "Purine nucleobase metabolic process", "Purine nucleoside biosynthetic process", "Purine nucleoside catabolic process", "Purine nucleoside diphosphate biosynthetic process", "Purine nucleoside metabolic process", "Purine nucleoside monophosphate biosynthetic process", "Purine nucleoside monophosphate catabolic process", "Purine nucleoside monophosphate metabolic process", "Purine nucleoside triphosphate catabolic process", "Purine nucleotide catabolic process", "Purine nucleotide salvage", "Purine nucleotide transport", "Purine ribonucleoside catabolic process", "Purine ribonucleoside metabolic process", "Purine ribonucleoside salvage", "Purine ribonucleotide salvage", "Purinergic nucleotide receptor signaling pathway", "Pyramidal neuron development", "Pyramidal neuron differentiation", "Pyridine containing compound biosynthetic process", "Pyridine containing compound catabolic process", "Pyridine containing compound metabolic process", "Pyridine nucleotide biosynthetic process", "Pyridine nucleotide metabolic process", "Pyrimidine containing compound biosynthetic process", "Pyrimidine containing compound catabolic process", "Pyrimidine containing compound metabolic process", "Pyrimidine containing compound salvage", "Pyrimidine containing compound transmembrane transport", "Pyrimidine deoxyribonucleoside metabolic process", "Pyrimidine deoxyribonucleoside monophosphate biosynthetic process", "Pyrimidine deoxyribonucleoside monophosphate metabolic process", "Pyrimidine deoxyribonucleoside triphosphate metabolic process", "Pyrimidine deoxyribonucleotide biosynthetic process", "Pyrimidine deoxyribonucleotide metabolic process", "Pyrimidine nucleobase biosynthetic process", "Pyrimidine nucleobase catabolic process", "Pyrimidine nucleobase metabolic process", "Pyrimidine nucleoside diphosphate biosynthetic process", "Pyrimidine nucleoside diphosphate metabolic process", "Pyrimidine nucleoside metabolic process", "Pyrimidine nucleoside monophosphate biosynthetic process", "Pyrimidine nucleoside monophosphate metabolic process", "Pyrimidine nucleoside triphosphate biosynthetic process", "Pyrimidine nucleoside triphosphate metabolic process", "Pyrimidine nucleotide catabolic process", "Pyrimidine nucleotide metabolic process", "Pyrimidine ribonucleoside diphosphate metabolic process", "Pyrimidine ribonucleoside monophosphate metabolic process", "Pyrimidine ribonucleoside triphosphate biosynthetic process", "Pyrimidine ribonucleoside triphosphate metabolic process", "Pyrimidine ribonucleotide biosynthetic process", "Pyrimidine ribonucleotide metabolic process", "Pyroptosis", "Pyruvate metabolic process", "Pyruvate transmembrane transport", "Pyruvate transport", "Quaternary ammonium group transport", "Quinone metabolic process", "R loop disassembly", "Rab protein signal transduction", "Rac protein signal transduction", "Radial glial cell differentiation", "Rap protein signal transduction", "Ras protein signal transduction", "Reactive nitrogen species metabolic process", "Reactive oxygen species biosynthetic process", "Reactive oxygen species metabolic process", "Receptor catabolic process", "Receptor clustering", "Receptor diffusion trapping", "Receptor internalization", "Receptor localization to synapse", "Receptor mediated endocytosis", "Receptor mediated endocytosis involved in cholesterol transport", "Receptor metabolic process", "Receptor recycling", "Receptor signaling pathway via stat", "Recognition of apoptotic cell", "Recombinational repair", "Reelin mediated signaling pathway", "Reflex", "Regeneration", "Regionalization", "Regulated exocytosis", "Regulation by virus of viral protein levels in host cell", "Regulation of 3 utr mediated mrna stabilization", "Regulation of actin cytoskeleton reorganization", "Regulation of actin filament based movement", "Regulation of actin filament based process", "Regulation of actin filament bundle assembly", "Regulation of actin filament length", "Regulation of actin filament organization", "Regulation of actin nucleation", "Regulation of action potential", "Regulation of activin receptor signaling pathway", "Regulation of actomyosin structure organization", "Regulation of acute inflammatory response", "Regulation of acute inflammatory response to antigenic stimulus", "Regulation of acyl coa biosynthetic process", "Regulation of adaptive immune response", "Regulation of adenylate cyclase activating g protein coupled receptor signaling pathway", "Regulation of adenylate cyclase activity", "Regulation of adherens junction organization", "Regulation of aerobic respiration", "Regulation of alcohol biosynthetic process", "Regulation of alpha beta t cell activation", "Regulation of alpha beta t cell differentiation", "Regulation of alternative mrna splicing via spliceosome", "Regulation of amino acid transmembrane transport", "Regulation of amino acid transport", "Regulation of amyloid beta clearance", "Regulation of amyloid fibril formation", "Regulation of amyloid precursor protein catabolic process", "Regulation of anaphase promoting complex dependent catabolic process", "Regulation of anatomical structure morphogenesis", "Regulation of anatomical structure size", "Regulation of androgen receptor signaling pathway", "Regulation of angiotensin levels in blood", "Regulation of animal organ formation", "Regulation of animal organ morphogenesis", "Regulation of anion channel activity", "Regulation of anion transmembrane transport", "Regulation of anion transport", "Regulation of anoikis", "Regulation of antigen receptor mediated signaling pathway", "Regulation of apoptotic cell clearance", "Regulation of apoptotic dna fragmentation", "Regulation of apoptotic process involved in development", "Regulation of apoptotic signaling pathway", "Regulation of appetite", "Regulation of arachidonic acid secretion", "Regulation of arp2 3 complex mediated actin nucleation", "Regulation of aspartic type endopeptidase activity involved in amyloid precursor protein catabolic process", "Regulation of aspartic type peptidase activity", "Regulation of astrocyte activation", "Regulation of astrocyte differentiation", "Regulation of atp biosynthetic process", "Regulation of atp dependent activity", "Regulation of atp metabolic process", "Regulation of atpase coupled calcium transmembrane transporter activity", "Regulation of atrial cardiac muscle cell membrane repolarization", "Regulation of attachment of spindle microtubules to kinetochore", "Regulation of autophagosome maturation", "Regulation of autophagy", "Regulation of autophagy of mitochondrion", "Regulation of autophagy of mitochondrion in response to mitochondrial depolarization", "Regulation of axon diameter", "Regulation of axon guidance", "Regulation of axonogenesis", "Regulation of b cell activation", "Regulation of b cell apoptotic process", "Regulation of b cell differentiation", "Regulation of b cell mediated immunity", "Regulation of b cell proliferation", "Regulation of b cell receptor signaling pathway", "Regulation of barbed end actin filament capping", "Regulation of behavior", "Regulation of bicellular tight junction assembly", "Regulation of bile acid secretion", "Regulation of binding", "Regulation of biological process involved in symbiotic interaction", "Regulation of biomineralization", "Regulation of blood brain barrier permeability", "Regulation of blood circulation", "Regulation of blood pressure", "Regulation of blood vessel remodeling", "Regulation of bmp signaling pathway", "Regulation of body fluid levels", "Regulation of bone mineralization", "Regulation of bone remodeling", "Regulation of bone resorption", "Regulation of branching involved in lung morphogenesis", "Regulation of branching morphogenesis of a nerve", "Regulation of brown fat cell differentiation", "Regulation of calcineurin mediated signaling", "Regulation of calcium ion dependent exocytosis", "Regulation of calcium ion export across plasma membrane", "Regulation of calcium ion import", "Regulation of calcium ion transmembrane transport", "Regulation of calcium ion transmembrane transporter activity", "Regulation of calcium ion transport", "Regulation of calcium ion transport into cytosol", "Regulation of calcium mediated signaling", "Regulation of camp dependent protein kinase activity", "Regulation of camp mediated signaling", "Regulation of canonical wnt signaling pathway", "Regulation of carbohydrate biosynthetic process", "Regulation of carbohydrate catabolic process", "Regulation of carbohydrate metabolic process", "Regulation of cardiac conduction", "Regulation of cardiac muscle adaptation", "Regulation of cardiac muscle cell action potential", "Regulation of cardiac muscle cell action potential involved in regulation of contraction", "Regulation of cardiac muscle cell membrane potential", "Regulation of cardiac muscle cell membrane repolarization", "Regulation of cardiac muscle cell proliferation", "Regulation of cardiac muscle contraction", "Regulation of cardiac muscle contraction by calcium ion signaling", "Regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion", "Regulation of cardioblast differentiation", "Regulation of cardiocyte differentiation", "Regulation of cartilage development", "Regulation of catabolic process", "Regulation of catecholamine metabolic process", "Regulation of cation channel activity", "Regulation of cation transmembrane transport", "Regulation of caveolin mediated endocytosis", "Regulation of cd4 positive alpha beta t cell activation", "Regulation of cd4 positive alpha beta t cell differentiation", "Regulation of cd40 signaling pathway", "Regulation of cd8 positive alpha beta t cell activation", "Regulation of cdc42 protein signal transduction", "Regulation of cell activation", "Regulation of cell adhesion", "Regulation of cell adhesion mediated by integrin", "Regulation of cell aging", "Regulation of cell cell adhesion", "Regulation of cell cell adhesion mediated by cadherin", "Regulation of cell cell adhesion mediated by integrin", "Regulation of cell communication by electrical coupling", "Regulation of cell communication by electrical coupling involved in cardiac conduction", "Regulation of cell cycle", "Regulation of cell cycle checkpoint", "Regulation of cell cycle g1 s phase transition", "Regulation of cell cycle g2 m phase transition", "Regulation of cell cycle phase transition", "Regulation of cell cycle process", "Regulation of cell death", "Regulation of cell development", "Regulation of cell differentiation", "Regulation of cell division", "Regulation of cell growth involved in cardiac muscle cell development", "Regulation of cell junction assembly", "Regulation of cell killing", "Regulation of cell matrix adhesion", "Regulation of cell maturation", "Regulation of cell migration involved in sprouting angiogenesis", "Regulation of cell morphogenesis", "Regulation of cell morphogenesis involved in differentiation", "Regulation of cell population proliferation", "Regulation of cell projection assembly", "Regulation of cell projection organization", "Regulation of cell projection size", "Regulation of cell shape", "Regulation of cell size", "Regulation of cell substrate adhesion", "Regulation of cell substrate junction organization", "Regulation of cellular amide metabolic process", "Regulation of cellular amine metabolic process", "Regulation of cellular amino acid metabolic process", "Regulation of cellular carbohydrate catabolic process", "Regulation of cellular carbohydrate metabolic process", "Regulation of cellular component biogenesis", "Regulation of cellular component movement", "Regulation of cellular component size", "Regulation of cellular extravasation", "Regulation of cellular ketone metabolic process", "Regulation of cellular localization", "Regulation of cellular macromolecule biosynthetic process", "Regulation of cellular ph", "Regulation of cellular ph reduction", "Regulation of cellular protein catabolic process", "Regulation of cellular respiration", "Regulation of cellular response to growth factor stimulus", "Regulation of cellular response to heat", "Regulation of cellular response to hypoxia", "Regulation of cellular response to insulin stimulus", "Regulation of cellular response to osmotic stress", "Regulation of cellular response to stress", "Regulation of cellular response to transforming growth factor beta stimulus", "Regulation of cellular response to vascular endothelial growth factor stimulus", "Regulation of centriole replication", "Regulation of centrosome cycle", "Regulation of chaperone mediated autophagy", "Regulation of chemokine mediated signaling pathway", "Regulation of chemotaxis", "Regulation of chloride transport", "Regulation of cholesterol biosynthetic process", "Regulation of cholesterol efflux", "Regulation of cholesterol esterification", "Regulation of cholesterol metabolic process", "Regulation of chondrocyte differentiation", "Regulation of chromatin assembly", "Regulation of chromatin assembly or disassembly", "Regulation of chromatin binding", "Regulation of chromatin organization", "Regulation of chromosome condensation", "Regulation of chromosome organization", "Regulation of chromosome segregation", "Regulation of chromosome separation", "Regulation of cilium assembly", "Regulation of cilium beat frequency", "Regulation of cilium beat frequency involved in ciliary motility", "Regulation of cilium dependent cell motility", "Regulation of cilium movement", "Regulation of circadian rhythm", "Regulation of clathrin dependent endocytosis", "Regulation of coagulation", "Regulation of collagen fibril organization", "Regulation of collagen metabolic process", "Regulation of collateral sprouting", "Regulation of complement activation", "Regulation of complement dependent cytotoxicity", "Regulation of connective tissue replacement", "Regulation of core promoter binding", "Regulation of cyclase activity", "Regulation of cyclic nucleotide phosphodiesterase activity", "Regulation of cyclin dependent protein kinase activity", "Regulation of cysteine type endopeptidase activity", "Regulation of cysteine type endopeptidase activity involved in apoptotic signaling pathway", "Regulation of cysteine type endopeptidase activity involved in execution phase of apoptosis", "Regulation of cytokinesis", "Regulation of cytoplasmic mrna processing body assembly", "Regulation of cytoplasmic translation", "Regulation of cytoplasmic translational elongation", "Regulation of cytoplasmic translational initiation", "Regulation of cytoplasmic transport", "Regulation of cytoskeleton organization", "Regulation of cytosolic calcium ion concentration", "Regulation of deacetylase activity", "Regulation of defense response", "Regulation of defense response to bacterium", "Regulation of defense response to virus", "Regulation of defense response to virus by host", "Regulation of delayed rectifier potassium channel activity", "Regulation of dendrite development", "Regulation of dendrite extension", "Regulation of dendrite morphogenesis", "Regulation of dendritic cell chemotaxis", "Regulation of dendritic cell differentiation", "Regulation of dendritic spine development", "Regulation of dendritic spine maintenance", "Regulation of dendritic spine morphogenesis", "Regulation of deoxyribonuclease activity", "Regulation of dephosphorylation", "Regulation of development heterochronic", "Regulation of developmental growth", "Regulation of digestive system process", "Regulation of dna binding", "Regulation of dna binding transcription factor activity", "Regulation of dna biosynthetic process", "Regulation of dna catabolic process", "Regulation of dna damage checkpoint", "Regulation of dna damage response signal transduction by p53 class mediator", "Regulation of dna damage response signal transduction by p53 class mediator resulting in transcription of p21 class mediator", "Regulation of dna demethylation", "Regulation of dna dependent dna replication", "Regulation of dna dependent dna replication initiation", "Regulation of dna directed dna polymerase activity", "Regulation of dna duplex unwinding", "Regulation of dna helicase activity", "Regulation of dna ligation", "Regulation of dna metabolic process", "Regulation of dna methylation", "Regulation of dna methylation dependent heterochromatin assembly", "Regulation of dna primase activity", "Regulation of dna recombination", "Regulation of dna repair", "Regulation of dna replication", "Regulation of dna strand elongation", "Regulation of dna templated transcription elongation", "Regulation of dna templated transcription in response to stress", "Regulation of dna templated transcription initiation", "Regulation of dna topoisomerase atp hydrolyzing activity", "Regulation of dopamine receptor signaling pathway", "Regulation of dopamine uptake involved in synaptic transmission", "Regulation of dopaminergic neuron differentiation", "Regulation of double strand break repair", "Regulation of double strand break repair via homologous recombination", "Regulation of double strand break repair via nonhomologous end joining", "Regulation of early endosome to late endosome transport", "Regulation of electron transfer activity", "Regulation of embryonic development", "Regulation of enamel mineralization", "Regulation of endocrine process", "Regulation of endocytic recycling", "Regulation of endocytosis", "Regulation of endodeoxyribonuclease activity", "Regulation of endodermal cell differentiation", "Regulation of endoplasmic reticulum stress induced intrinsic apoptotic signaling pathway", "Regulation of endoplasmic reticulum tubular network organization", "Regulation of endoplasmic reticulum unfolded protein response", "Regulation of endothelial cell chemotaxis", "Regulation of endothelial cell development", "Regulation of endothelial cell differentiation", "Regulation of endothelial cell migration", "Regulation of entry of bacterium into host cell", "Regulation of epidermal growth factor activated receptor activity", "Regulation of epidermis development", "Regulation of epithelial cell apoptotic process", "Regulation of epithelial cell differentiation", "Regulation of epithelial cell differentiation involved in kidney development", "Regulation of epithelial cell migration", "Regulation of epithelial cell proliferation involved in lung morphogenesis", "Regulation of epithelial to mesenchymal transition", "Regulation of er associated ubiquitin dependent protein catabolic process", "Regulation of er to golgi vesicle mediated transport", "Regulation of erad pathway", "Regulation of erbb signaling pathway", "Regulation of erythrocyte differentiation", "Regulation of establishment of planar polarity", "Regulation of establishment of protein localization", "Regulation of establishment of protein localization to chromosome", "Regulation of establishment of protein localization to mitochondrion", "Regulation of establishment or maintenance of cell polarity", "Regulation of excretion", "Regulation of execution phase of apoptosis", "Regulation of exit from mitosis", "Regulation of exocytosis", "Regulation of exosomal secretion", "Regulation of extent of cell growth", "Regulation of extracellular matrix assembly", "Regulation of extracellular matrix disassembly", "Regulation of extracellular matrix organization", "Regulation of extrinsic apoptotic signaling pathway", "Regulation of extrinsic apoptotic signaling pathway in absence of ligand", "Regulation of extrinsic apoptotic signaling pathway via death domain receptors", "Regulation of fat cell differentiation", "Regulation of fat cell proliferation", "Regulation of fatty acid beta oxidation", "Regulation of fatty acid biosynthetic process", "Regulation of fatty acid metabolic process", "Regulation of fatty acid oxidation", "Regulation of fatty acid transport", "Regulation of fc gamma receptor signaling pathway involved in phagocytosis", "Regulation of fc receptor mediated stimulatory signaling pathway", "Regulation of feeding behavior", "Regulation of fertilization", "Regulation of fibroblast growth factor receptor signaling pathway", "Regulation of fibroblast migration", "Regulation of filopodium assembly", "Regulation of focal adhesion disassembly", "Regulation of g protein coupled receptor signaling pathway", "Regulation of g0 to g1 transition", "Regulation of gamma aminobutyric acid secretion", "Regulation of gastrulation", "Regulation of gene expression by genomic imprinting", "Regulation of gene expression epigenetic", "Regulation of gene silencing by rna", "Regulation of generation of precursor metabolites and energy", "Regulation of genetic imprinting", "Regulation of germ cell proliferation", "Regulation of germinal center formation", "Regulation of glial cell apoptotic process", "Regulation of glial cell differentiation", "Regulation of glial cell migration", "Regulation of glial cell proliferation", "Regulation of gliogenesis", "Regulation of glucagon secretion", "Regulation of glucan biosynthetic process", "Regulation of glucocorticoid biosynthetic process", "Regulation of glucocorticoid metabolic process", "Regulation of glucocorticoid receptor signaling pathway", "Regulation of glucocorticoid secretion", "Regulation of gluconeogenesis", "Regulation of glucose import", "Regulation of glucose metabolic process", "Regulation of glucose transmembrane transport", "Regulation of glucosylceramidase activity", "Regulation of glutamate receptor clustering", "Regulation of glutamate secretion", "Regulation of glutamine family amino acid metabolic process", "Regulation of glycogen catabolic process", "Regulation of glycogen metabolic process", "Regulation of glycogen starch synthase activity", "Regulation of glycolytic process", "Regulation of glycoprotein metabolic process", "Regulation of golgi organization", "Regulation of golgi to plasma membrane protein transport", "Regulation of gonad development", "Regulation of granulocyte chemotaxis", "Regulation of granulocyte differentiation", "Regulation of growth", "Regulation of gtp binding", "Regulation of gtpase activity", "Regulation of guanyl nucleotide exchange factor activity", "Regulation of hair cycle", "Regulation of hair follicle development", "Regulation of heart contraction", "Regulation of heart growth", "Regulation of heart morphogenesis", "Regulation of heart rate", "Regulation of heart rate by cardiac conduction", "Regulation of heart rate by chemical signal", "Regulation of helicase activity", "Regulation of hematopoietic progenitor cell differentiation", "Regulation of hematopoietic stem cell differentiation", "Regulation of hematopoietic stem cell proliferation", "Regulation of hemoglobin biosynthetic process", "Regulation of hemopoiesis", "Regulation of hepatic stellate cell activation", "Regulation of hepatocyte apoptotic process", "Regulation of heterotypic cell cell adhesion", "Regulation of hexokinase activity", "Regulation of high voltage gated calcium channel activity", "Regulation of hippo signaling", "Regulation of histamine secretion by mast cell", "Regulation of histone deacetylase activity", "Regulation of histone deacetylation", "Regulation of histone h2b ubiquitination", "Regulation of histone h3 k14 acetylation", "Regulation of histone h3 k27 methylation", "Regulation of histone h3 k36 methylation", "Regulation of histone h3 k4 methylation", "Regulation of histone h3 k9 methylation", "Regulation of histone h3 k9 trimethylation", "Regulation of histone h4 acetylation", "Regulation of histone h4 k16 acetylation", "Regulation of histone methylation", "Regulation of histone modification", "Regulation of histone phosphorylation", "Regulation of histone ubiquitination", "Regulation of homophilic cell adhesion", "Regulation of homotypic cell cell adhesion", "Regulation of hormone biosynthetic process", "Regulation of hormone levels", "Regulation of hormone metabolic process", "Regulation of hormone secretion", "Regulation of humoral immune response", "Regulation of hyaluronan biosynthetic process", "Regulation of hydrogen peroxide biosynthetic process", "Regulation of hydrogen peroxide mediated programmed cell death", "Regulation of hydrogen peroxide metabolic process", "Regulation of hydrolase activity", "Regulation of i kappab phosphorylation", "Regulation of icosanoid secretion", "Regulation of immune effector process", "Regulation of immune response", "Regulation of immune system process", "Regulation of immunoglobulin production", "Regulation of inclusion body assembly", "Regulation of inflammatory response", "Regulation of inflammatory response to antigenic stimulus", "Regulation of innate immune response", "Regulation of inositol 1 4 5 trisphosphate sensitive calcium release channel activity", "Regulation of insulin like growth factor receptor signaling pathway", "Regulation of insulin receptor signaling pathway", "Regulation of insulin secretion", "Regulation of insulin secretion involved in cellular response to glucose stimulus", "Regulation of integrin activation", "Regulation of integrin mediated signaling pathway", "Regulation of interleukin 1 mediated signaling pathway", "Regulation of interleukin 6 mediated signaling pathway", "Regulation of intestinal absorption", "Regulation of intracellular estrogen receptor signaling pathway", "Regulation of intracellular lipid transport", "Regulation of intracellular protein transport", "Regulation of intracellular signal transduction", "Regulation of intracellular steroid hormone receptor signaling pathway", "Regulation of intracellular transport", "Regulation of intrinsic apoptotic signaling pathway", "Regulation of intrinsic apoptotic signaling pathway by p53 class mediator", "Regulation of intrinsic apoptotic signaling pathway in response to dna damage", "Regulation of intrinsic apoptotic signaling pathway in response to dna damage by p53 class mediator", "Regulation of intrinsic apoptotic signaling pathway in response to osmotic stress", "Regulation of inward rectifier potassium channel activity", "Regulation of ion transmembrane transport", "Regulation of ion transport", "Regulation of ire1 mediated unfolded protein response", "Regulation of iron ion transmembrane transport", "Regulation of iron ion transport", "Regulation of isomerase activity", "Regulation of isotype switching", "Regulation of jnk cascade", "Regulation of jun kinase activity", "Regulation of keratinocyte differentiation", "Regulation of keratinocyte migration", "Regulation of keratinocyte proliferation", "Regulation of kidney development", "Regulation of l glutamate import across plasma membrane", "Regulation of lamellipodium assembly", "Regulation of lamellipodium morphogenesis", "Regulation of lamellipodium organization", "Regulation of leukocyte apoptotic process", "Regulation of leukocyte chemotaxis", "Regulation of leukocyte degranulation", "Regulation of leukocyte differentiation", "Regulation of leukocyte mediated cytotoxicity", "Regulation of leukocyte mediated immunity", "Regulation of leukocyte migration", "Regulation of leukocyte proliferation", "Regulation of ligase activity", "Regulation of lipase activity", "Regulation of lipid biosynthetic process", "Regulation of lipid catabolic process", "Regulation of lipid kinase activity", "Regulation of lipid localization", "Regulation of lipid metabolic process", "Regulation of lipid storage", "Regulation of lipid transport", "Regulation of lipophagy", "Regulation of lipopolysaccharide mediated signaling pathway", "Regulation of lipoprotein lipase activity", "Regulation of lipoprotein metabolic process", "Regulation of lipoprotein particle clearance", "Regulation of locomotion involved in locomotory behavior", "Regulation of long chain fatty acid import across plasma membrane", "Regulation of long chain fatty acid import into cell", "Regulation of long term neuronal synaptic plasticity", "Regulation of long term synaptic depression", "Regulation of long term synaptic potentiation", "Regulation of low density lipoprotein particle clearance", "Regulation of lyase activity", "Regulation of lymphangiogenesis", "Regulation of lymphocyte activation", "Regulation of lymphocyte apoptotic process", "Regulation of lymphocyte chemotaxis", "Regulation of lymphocyte differentiation", "Regulation of lymphocyte mediated immunity", "Regulation of lymphocyte migration", "Regulation of lymphoid progenitor cell differentiation", "Regulation of lysosomal lumen ph", "Regulation of lysosomal protein catabolic process", "Regulation of lysosome organization", "Regulation of macroautophagy", "Regulation of macrophage activation", "Regulation of macrophage apoptotic process", "Regulation of macrophage chemotaxis", "Regulation of macrophage differentiation", "Regulation of macrophage migration", "Regulation of macrophage proliferation", "Regulation of maintenance of sister chromatid cohesion", "Regulation of male gonad development", "Regulation of mammary gland epithelial cell proliferation", "Regulation of map kinase activity", "Regulation of mast cell activation", "Regulation of mast cell activation involved in immune response", "Regulation of matrix metallopeptidase secretion", "Regulation of mda 5 signaling pathway", "Regulation of megakaryocyte differentiation", "Regulation of meiotic cell cycle", "Regulation of meiotic cell cycle phase transition", "Regulation of meiotic nuclear division", "Regulation of membrane depolarization", "Regulation of membrane depolarization during action potential", "Regulation of membrane depolarization during cardiac muscle cell action potential", "Regulation of membrane invagination", "Regulation of membrane lipid distribution", "Regulation of membrane permeability", "Regulation of membrane potential", "Regulation of membrane protein ectodomain proteolysis", "Regulation of membrane repolarization", "Regulation of membrane repolarization during action potential", "Regulation of membrane repolarization during cardiac muscle cell action potential", "Regulation of membrane tubulation", "Regulation of mesenchymal cell proliferation", "Regulation of mesenchymal stem cell differentiation", "Regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis", "Regulation of mesoderm development", "Regulation of metal ion transport", "Regulation of metalloendopeptidase activity", "Regulation of metallopeptidase activity", "Regulation of metanephros development", "Regulation of metaphase plate congression", "Regulation of microglial cell activation", "Regulation of microtubule based movement", "Regulation of microtubule based process", "Regulation of microtubule binding", "Regulation of microtubule cytoskeleton organization", "Regulation of microtubule depolymerization", "Regulation of microtubule nucleation", "Regulation of microtubule polymerization", "Regulation of microtubule polymerization or depolymerization", "Regulation of microvillus assembly", "Regulation of microvillus length", "Regulation of microvillus organization", "Regulation of mirna catabolic process", "Regulation of mirna metabolic process", "Regulation of mirna transcription", "Regulation of mitochondrial atp synthesis coupled electron transport", "Regulation of mitochondrial dna replication", "Regulation of mitochondrial electron transport nadh to ubiquinone", "Regulation of mitochondrial fission", "Regulation of mitochondrial fusion", "Regulation of mitochondrial gene expression", "Regulation of mitochondrial membrane permeability", "Regulation of mitochondrial membrane permeability involved in apoptotic process", "Regulation of mitochondrial membrane potential", "Regulation of mitochondrial mrna stability", "Regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway", "Regulation of mitochondrial rna catabolic process", "Regulation of mitochondrion organization", "Regulation of mitophagy", "Regulation of mitotic cell cycle", "Regulation of mitotic cell cycle phase transition", "Regulation of mitotic cell cycle spindle assembly checkpoint", "Regulation of mitotic centrosome separation", "Regulation of mitotic cytokinesis", "Regulation of mitotic nuclear division", "Regulation of mitotic recombination", "Regulation of mitotic sister chromatid segregation", "Regulation of mitotic spindle assembly", "Regulation of modification of postsynaptic structure", "Regulation of modification of synaptic structure", "Regulation of monocyte chemotaxis", "Regulation of monocyte differentiation", "Regulation of monocyte extravasation", "Regulation of mononuclear cell migration", "Regulation of monooxygenase activity", "Regulation of morphogenesis of a branching structure", "Regulation of morphogenesis of an epithelium", "Regulation of motor neuron apoptotic process", "Regulation of mrna 3 end processing", "Regulation of mrna binding", "Regulation of mrna catabolic process", "Regulation of mrna export from nucleus", "Regulation of mrna metabolic process", "Regulation of mrna polyadenylation", "Regulation of mrna processing", "Regulation of mrna splicing via spliceosome", "Regulation of mucus secretion", "Regulation of multicellular organism growth", "Regulation of multicellular organismal development", "Regulation of muscle adaptation", "Regulation of muscle cell differentiation", "Regulation of muscle contraction", "Regulation of muscle hypertrophy", "Regulation of muscle organ development", "Regulation of muscle system process", "Regulation of myelination", "Regulation of myeloid cell apoptotic process", "Regulation of myeloid cell differentiation", "Regulation of myeloid leukocyte differentiation", "Regulation of myeloid leukocyte mediated immunity", "Regulation of myoblast differentiation", "Regulation of myoblast fusion", "Regulation of myosin light chain phosphatase activity", "Regulation of myotube differentiation", "Regulation of nad p h oxidase activity", "Regulation of nadp metabolic process", "Regulation of natural killer cell activation", "Regulation of natural killer cell mediated immunity", "Regulation of necrotic cell death", "Regulation of nervous system development", "Regulation of nervous system process", "Regulation of neural precursor cell proliferation", "Regulation of neuroblast proliferation", "Regulation of neurogenesis", "Regulation of neuromuscular junction development", "Regulation of neuron differentiation", "Regulation of neuron migration", "Regulation of neuron projection arborization", "Regulation of neuron projection development", "Regulation of neuron projection regeneration", "Regulation of neuronal action potential", "Regulation of neuronal synaptic plasticity", "Regulation of neurotransmitter levels", "Regulation of neurotransmitter receptor activity", "Regulation of neurotransmitter transport", "Regulation of neurotransmitter uptake", "Regulation of neurotrophin trk receptor signaling pathway", "Regulation of neutrophil activation", "Regulation of neutrophil chemotaxis", "Regulation of neutrophil degranulation", "Regulation of neutrophil migration", "Regulation of nik nf kappab signaling", "Regulation of nitric oxide mediated signal transduction", "Regulation of nitric oxide metabolic process", "Regulation of nitric oxide synthase activity", "Regulation of nk t cell activation", "Regulation of nk t cell differentiation", "Regulation of nmda receptor activity", "Regulation of non membrane spanning protein tyrosine kinase activity", "Regulation of non motile cilium assembly", "Regulation of notch signaling pathway", "Regulation of nuclear cell cycle dna replication", "Regulation of nuclear division", "Regulation of nuclear transcribed mrna catabolic process deadenylation dependent decay", "Regulation of nuclear transcribed mrna catabolic process nonsense mediated decay", "Regulation of nuclear transcribed mrna poly a tail shortening", "Regulation of nuclease activity", "Regulation of nucleobase containing compound transport", "Regulation of nucleocytoplasmic transport", "Regulation of nucleotide binding oligomerization domain containing 2 signaling pathway", "Regulation of nucleotide binding oligomerization domain containing signaling pathway", "Regulation of nucleotide biosynthetic process", "Regulation of nucleotide metabolic process", "Regulation of oligodendrocyte differentiation", "Regulation of oocyte maturation", "Regulation of opsonization", "Regulation of organ growth", "Regulation of organelle assembly", "Regulation of organelle organization", "Regulation of organelle transport along microtubule", "Regulation of organic acid transport", "Regulation of ossification", "Regulation of osteoblast differentiation", "Regulation of osteoblast proliferation", "Regulation of osteoclast development", "Regulation of osteoclast differentiation", "Regulation of ovarian follicle development", "Regulation of oxidative phosphorylation", "Regulation of oxidative stress induced cell death", "Regulation of oxidative stress induced intrinsic apoptotic signaling pathway", "Regulation of oxidoreductase activity", "Regulation of p38mapk cascade", "Regulation of pattern recognition receptor signaling pathway", "Regulation of penile erection", "Regulation of peptidase activity", "Regulation of peptide transport", "Regulation of peptidyl cysteine s nitrosylation", "Regulation of peptidyl lysine acetylation", "Regulation of peptidyl serine phosphorylation", "Regulation of peptidyl serine phosphorylation of stat protein", "Regulation of peptidyl threonine phosphorylation", "Regulation of peptidyl tyrosine phosphorylation", "Regulation of perk mediated unfolded protein response", "Regulation of ph", "Regulation of phagocytosis", "Regulation of phenotypic switching", "Regulation of phosphatase activity", "Regulation of phosphatidylcholine biosynthetic process", "Regulation of phosphatidylcholine metabolic process", "Regulation of phosphatidylinositol 3 kinase activity", "Regulation of phosphatidylinositol 3 kinase signaling", "Regulation of phosphatidylinositol dephosphorylation", "Regulation of phospholipase a2 activity", "Regulation of phospholipase activity", "Regulation of phospholipase c activity", "Regulation of phospholipid biosynthetic process", "Regulation of phospholipid catabolic process", "Regulation of phospholipid metabolic process", "Regulation of phosphoprotein phosphatase activity", "Regulation of phosphorus metabolic process", "Regulation of pigmentation", "Regulation of pinocytosis", "Regulation of plasma lipoprotein particle levels", "Regulation of plasma membrane organization", "Regulation of plasminogen activation", "Regulation of platelet activation", "Regulation of platelet aggregation", "Regulation of platelet derived growth factor receptor beta signaling pathway", "Regulation of platelet derived growth factor receptor signaling pathway", "Regulation of podosome assembly", "Regulation of polysaccharide metabolic process", "Regulation of post translational protein modification", "Regulation of postsynapse organization", "Regulation of postsynaptic cytosolic calcium ion concentration", "Regulation of postsynaptic density organization", "Regulation of postsynaptic membrane neurotransmitter receptor levels", "Regulation of postsynaptic membrane potential", "Regulation of postsynaptic neurotransmitter receptor activity", "Regulation of postsynaptic neurotransmitter receptor internalization", "Regulation of potassium ion export across plasma membrane", "Regulation of potassium ion import", "Regulation of potassium ion transmembrane transporter activity", "Regulation of potassium ion transport", "Regulation of presynapse organization", "Regulation of presynaptic cytosolic calcium ion concentration", "Regulation of pro b cell differentiation", "Regulation of production of molecular mediator of immune response", "Regulation of production of small rna involved in gene silencing by rna", "Regulation of programmed necrotic cell death", "Regulation of prostaglandin secretion", "Regulation of proteasomal protein catabolic process", "Regulation of proteasomal ubiquitin dependent protein catabolic process", "Regulation of protein acetylation", "Regulation of protein adp ribosylation", "Regulation of protein autophosphorylation", "Regulation of protein autoubiquitination", "Regulation of protein binding", "Regulation of protein catabolic process", "Regulation of protein catabolic process in the vacuole", "Regulation of protein complex stability", "Regulation of protein containing complex assembly", "Regulation of protein containing complex disassembly", "Regulation of protein deacetylation", "Regulation of protein dephosphorylation", "Regulation of protein depolymerization", "Regulation of protein deubiquitination", "Regulation of protein exit from endoplasmic reticulum", "Regulation of protein export from nucleus", "Regulation of protein folding", "Regulation of protein glycosylation", "Regulation of protein import", "Regulation of protein k63 linked ubiquitination", "Regulation of protein kinase a signaling", "Regulation of protein kinase activity", "Regulation of protein kinase c signaling", "Regulation of protein lipidation", "Regulation of protein localization", "Regulation of protein localization to cell cortex", "Regulation of protein localization to cell periphery", "Regulation of protein localization to cell surface", "Regulation of protein localization to centrosome", "Regulation of protein localization to chromatin", "Regulation of protein localization to chromosome telomeric region", "Regulation of protein localization to cilium", "Regulation of protein localization to endosome", "Regulation of protein localization to membrane", "Regulation of protein localization to nucleolus", "Regulation of protein localization to nucleus", "Regulation of protein localization to plasma membrane", "Regulation of protein localization to synapse", "Regulation of protein maturation", "Regulation of protein modification by small protein conjugation or removal", "Regulation of protein modification process", "Regulation of protein monoubiquitination", "Regulation of protein neddylation", "Regulation of protein phosphorylation", "Regulation of protein polymerization", "Regulation of protein polyubiquitination", "Regulation of protein secretion", "Regulation of protein serine threonine kinase activity", "Regulation of protein stability", "Regulation of protein sumoylation", "Regulation of protein targeting", "Regulation of protein targeting to membrane", "Regulation of protein tyrosine kinase activity", "Regulation of protein tyrosine phosphatase activity", "Regulation of proteolysis", "Regulation of proton transport", "Regulation of rac protein signal transduction", "Regulation of ras protein signal transduction", "Regulation of reactive oxygen species biosynthetic process", "Regulation of reactive oxygen species metabolic process", "Regulation of receptor binding", "Regulation of receptor catabolic process", "Regulation of receptor clustering", "Regulation of receptor internalization", "Regulation of receptor localization to synapse", "Regulation of receptor mediated endocytosis", "Regulation of receptor mediated endocytosis involved in cholesterol transport", "Regulation of receptor recycling", "Regulation of receptor signaling pathway via stat", "Regulation of regulated secretory pathway", "Regulation of relaxation of muscle", "Regulation of release of cytochrome c from mitochondria", "Regulation of release of sequestered calcium ion into cytosol", "Regulation of removal of superoxide radicals", "Regulation of renal system process", "Regulation of reproductive process", "Regulation of respiratory burst", "Regulation of respiratory gaseous exchange", "Regulation of respiratory gaseous exchange by nervous system process", "Regulation of respiratory system process", "Regulation of response to biotic stimulus", "Regulation of response to cytokine stimulus", "Regulation of response to dna damage stimulus", "Regulation of response to endoplasmic reticulum stress", "Regulation of response to external stimulus", "Regulation of response to extracellular stimulus", "Regulation of response to food", "Regulation of response to interferon gamma", "Regulation of response to osmotic stress", "Regulation of response to oxidative stress", "Regulation of response to reactive oxygen species", "Regulation of response to stress", "Regulation of response to tumor cell", "Regulation of response to wounding", "Regulation of retinal ganglion cell axon guidance", "Regulation of retinoic acid receptor signaling pathway", "Regulation of retrograde protein transport er to cytosol", "Regulation of retrograde transport endosome to golgi", "Regulation of rho dependent protein serine threonine kinase activity", "Regulation of rho protein signal transduction", "Regulation of rhodopsin mediated signaling pathway", "Regulation of ribonuclease activity", "Regulation of ribosome biogenesis", "Regulation of rig i signaling pathway", "Regulation of rna binding", "Regulation of rna export from nucleus", "Regulation of rna polymerase ii regulatory region sequence specific dna binding", "Regulation of rna polymerase ii transcription preinitiation complex assembly", "Regulation of rna splicing", "Regulation of rrna processing", "Regulation of ruffle assembly", "Regulation of ryanodine sensitive calcium release channel activity", "Regulation of secondary heart field cardioblast proliferation", "Regulation of secondary metabolic process", "Regulation of secretion", "Regulation of sequestering of triglyceride", "Regulation of sequestering of zinc ion", "Regulation of short term neuronal synaptic plasticity", "Regulation of signal transduction by p53 class mediator", "Regulation of signaling receptor activity", "Regulation of sister chromatid cohesion", "Regulation of skeletal muscle adaptation", "Regulation of skeletal muscle cell differentiation", "Regulation of skeletal muscle contraction", "Regulation of skeletal muscle contraction by calcium ion signaling", "Regulation of skeletal muscle fiber development", "Regulation of skeletal muscle tissue development", "Regulation of smad protein complex assembly", "Regulation of smad protein signal transduction", "Regulation of small gtpase mediated signal transduction", "Regulation of small molecule metabolic process", "Regulation of smooth muscle cell chemotaxis", "Regulation of smooth muscle cell differentiation", "Regulation of smooth muscle contraction", "Regulation of smoothened signaling pathway", "Regulation of smoothened signaling pathway involved in dorsal ventral neural tube patterning", "Regulation of snrna transcription by rna polymerase ii", "Regulation of sodium ion transmembrane transport", "Regulation of sodium ion transport", "Regulation of sodium proton antiporter activity", "Regulation of sphingolipid biosynthetic process", "Regulation of spindle assembly", "Regulation of spindle organization", "Regulation of spontaneous synaptic transmission", "Regulation of sprouting angiogenesis", "Regulation of srebp signaling pathway", "Regulation of stem cell differentiation", "Regulation of stem cell population maintenance", "Regulation of stem cell proliferation", "Regulation of steroid biosynthetic process", "Regulation of steroid hormone biosynthetic process", "Regulation of steroid hormone secretion", "Regulation of steroid metabolic process", "Regulation of sterol transport", "Regulation of stress activated protein kinase signaling cascade", "Regulation of stress granule assembly", "Regulation of striated muscle cell differentiation", "Regulation of striated muscle contraction", "Regulation of substrate adhesion dependent cell spreading", "Regulation of sulfur metabolic process", "Regulation of superoxide anion generation", "Regulation of superoxide dismutase activity", "Regulation of superoxide metabolic process", "Regulation of supramolecular fiber organization", "Regulation of synapse assembly", "Regulation of synapse maturation", "Regulation of synapse structural plasticity", "Regulation of synapse structure or activity", "Regulation of synaptic plasticity", "Regulation of synaptic transmission dopaminergic", "Regulation of synaptic transmission gabaergic", "Regulation of synaptic transmission glutamatergic", "Regulation of synaptic vesicle clustering", "Regulation of synaptic vesicle cycle", "Regulation of synaptic vesicle endocytosis", "Regulation of synaptic vesicle exocytosis", "Regulation of synaptic vesicle priming", "Regulation of synaptic vesicle recycling", "Regulation of syncytium formation by plasma membrane fusion", "Regulation of system process", "Regulation of systemic arterial blood pressure", "Regulation of systemic arterial blood pressure by circulatory renin angiotensin", "Regulation of systemic arterial blood pressure by endothelin", "Regulation of systemic arterial blood pressure by hormone", "Regulation of systemic arterial blood pressure by renin angiotensin", "Regulation of systemic arterial blood pressure mediated by a chemical signal", "Regulation of t cell activation", "Regulation of t cell activation via t cell receptor contact with antigen bound to mhc molecule on antigen presenting cell", "Regulation of t cell apoptotic process", "Regulation of t cell chemotaxis", "Regulation of t cell differentiation", "Regulation of t cell differentiation in thymus", "Regulation of t cell mediated cytotoxicity", "Regulation of t cell mediated immune response to tumor cell", "Regulation of t cell mediated immunity", "Regulation of t cell migration", "Regulation of t cell proliferation", "Regulation of t cell receptor signaling pathway", "Regulation of t circle formation", "Regulation of t helper 1 cell differentiation", "Regulation of t helper 1 type immune response", "Regulation of t helper 17 cell differentiation", "Regulation of t helper 17 type immune response", "Regulation of t helper 2 cell differentiation", "Regulation of t helper cell differentiation", "Regulation of tau protein kinase activity", "Regulation of telomerase activity", "Regulation of telomere capping", "Regulation of telomere maintenance", "Regulation of telomere maintenance via telomere lengthening", "Regulation of tetrapyrrole metabolic process", "Regulation of the force of heart contraction", "Regulation of thymocyte apoptotic process", "Regulation of tissue remodeling", "Regulation of tolerance induction", "Regulation of toll like receptor 2 signaling pathway", "Regulation of toll like receptor 3 signaling pathway", "Regulation of toll like receptor 4 signaling pathway", "Regulation of toll like receptor 7 signaling pathway", "Regulation of toll like receptor 9 signaling pathway", "Regulation of toll like receptor signaling pathway", "Regulation of tooth mineralization", "Regulation of tor signaling", "Regulation of torc2 signaling", "Regulation of trail activated apoptotic signaling pathway", "Regulation of trans synaptic signaling", "Regulation of transcription by glucose", "Regulation of transcription by rna polymerase i", "Regulation of transcription by rna polymerase iii", "Regulation of transcription elongation from rna polymerase ii promoter", "Regulation of transcription from rna polymerase ii promoter in response to hypoxia", "Regulation of transcription from rna polymerase ii promoter in response to oxidative stress", "Regulation of transcription from rna polymerase ii promoter involved in heart development", "Regulation of transcription involved in g1 s transition of mitotic cell cycle", "Regulation of transcription of nucleolar large rrna by rna polymerase i", "Regulation of transcription regulatory region dna binding", "Regulation of transferase activity", "Regulation of transforming growth factor beta activation", "Regulation of transforming growth factor beta1 production", "Regulation of translation at synapse modulating synaptic transmission", "Regulation of translation in response to endoplasmic reticulum stress", "Regulation of translation in response to stress", "Regulation of translation initiation in response to endoplasmic reticulum stress", "Regulation of translational elongation", "Regulation of translational fidelity", "Regulation of translational initiation", "Regulation of translational initiation by eif2 alpha phosphorylation", "Regulation of translational initiation in response to stress", "Regulation of translational termination", "Regulation of transmembrane receptor protein serine threonine kinase signaling pathway", "Regulation of transmembrane transport", "Regulation of transmission of nerve impulse", "Regulation of transport", "Regulation of transporter activity", "Regulation of transposition", "Regulation of triglyceride biosynthetic process", "Regulation of triglyceride catabolic process", "Regulation of triglyceride metabolic process", "Regulation of tube size", "Regulation of tumor necrosis factor mediated signaling pathway", "Regulation of type b pancreatic cell development", "Regulation of type i interferon mediated signaling pathway", "Regulation of ubiquitin dependent protein catabolic process", "Regulation of ubiquitin protein ligase activity", "Regulation of ubiquitin protein transferase activity", "Regulation of ubiquitin specific protease activity", "Regulation of unsaturated fatty acid biosynthetic process", "Regulation of urine volume", "Regulation of vacuole organization", "Regulation of vascular associated smooth muscle cell differentiation", "Regulation of vascular associated smooth muscle contraction", "Regulation of vascular endothelial growth factor receptor signaling pathway", "Regulation of vascular permeability", "Regulation of vascular wound healing", "Regulation of vasculature development", "Regulation of vasculogenesis", "Regulation of vasoconstriction", "Regulation of ventricular cardiac muscle cell action potential", "Regulation of ventricular cardiac muscle cell membrane depolarization", "Regulation of very low density lipoprotein particle clearance", "Regulation of vesicle fusion", "Regulation of vesicle mediated transport", "Regulation of vesicle size", "Regulation of viral entry into host cell", "Regulation of viral genome replication", "Regulation of viral induced cytoplasmic pattern recognition receptor signaling pathway", "Regulation of viral process", "Regulation of viral transcription", "Regulation of vitamin d receptor signaling pathway", "Regulation of vitamin metabolic process", "Regulation of voltage gated calcium channel activity", "Regulation of voltage gated sodium channel activity", "Regulation of water loss via skin", "Regulation of wnt signaling pathway", "Regulation of wnt signaling pathway involved in heart development", "Regulation of wound healing", "Regulation of wound healing spreading of epidermal cells", "Regulation of xenophagy", "Regulatory t cell differentiation", "Relaxation of cardiac muscle", "Relaxation of muscle", "Release of cytochrome c from mitochondria", "Release of sequestered calcium ion into cytosol by endoplasmic reticulum", "Renal absorption", "Renal filtration", "Renal sodium excretion", "Renal sodium ion absorption", "Renal sodium ion transport", "Renal system process", "Renal system vasculature development", "Renal system vasculature morphogenesis", "Renal tubular secretion", "Renal tubule development", "Renal vesicle development", "Renal vesicle formation", "Renal water homeostasis", "Replacement ossification", "Replication born double strand break repair via sister chromatid exchange", "Replication fork processing", "Replication fork protection", "Replicative senescence", "Reproduction", "Reproductive behavior", "Reproductive system development", "Rescue of stalled ribosome", "Resolution of meiotic recombination intermediates", "Resolution of recombination intermediates", "Respiratory burst", "Respiratory burst involved in defense response", "Respiratory burst involved in inflammatory response", "Respiratory chain complex iii assembly", "Respiratory chain complex iv assembly", "Respiratory electron transport chain", "Respiratory gaseous exchange by respiratory system", "Respiratory system development", "Respiratory system process", "Response to abiotic stimulus", "Response to acetylcholine", "Response to acid chemical", "Response to acidic ph", "Response to actinomycin d", "Response to activity", "Response to alcohol", "Response to aldosterone", "Response to alkaloid", "Response to amine", "Response to amino acid starvation", "Response to ammonium ion", "Response to amphetamine", "Response to amyloid beta", "Response to angiotensin", "Response to antibiotic", "Response to arsenic containing substance", "Response to arsenite ion", "Response to atp", "Response to auditory stimulus", "Response to axon injury", "Response to bacterium", "Response to bmp", "Response to cadmium ion", "Response to caffeine", "Response to calcium ion", "Response to camp", "Response to camptothecin", "Response to carbohydrate", "Response to catecholamine", "Response to cell cycle checkpoint signaling", "Response to cgmp", "Response to chemokine", "Response to cholesterol", "Response to cisplatin", "Response to cobalt ion", "Response to cocaine", "Response to cold", "Response to copper ion", "Response to corticosteroid", "Response to corticosterone", "Response to cortisol", "Response to cytokine", "Response to dexamethasone", "Response to dietary excess", "Response to dopamine", "Response to dsrna", "Response to electrical stimulus", "Response to endogenous stimulus", "Response to endoplasmic reticulum stress", "Response to epidermal growth factor", "Response to epinephrine", "Response to estradiol", "Response to estrogen", "Response to ethanol", "Response to ether", "Response to extracellular stimulus", "Response to fatty acid", "Response to fibroblast growth factor", "Response to fluid shear stress", "Response to folic acid", "Response to follicle stimulating hormone", "Response to food", "Response to forskolin", "Response to fungus", "Response to gamma radiation", "Response to glucagon", "Response to glycoside", "Response to gonadotropin", "Response to granulocyte macrophage colony stimulating factor", "Response to growth factor", "Response to growth hormone", "Response to heat", "Response to heparin", "Response to hepatocyte growth factor", "Response to histamine", "Response to hormone", "Response to human chorionic gonadotropin", "Response to hydrogen peroxide", "Response to hydroperoxide", "Response to hydrostatic pressure", "Response to hydroxyurea", "Response to hyperoxia", "Response to immobilization stress", "Response to increased oxygen levels", "Response to indole 3 methanol", "Response to inorganic substance", "Response to insecticide", "Response to insulin", "Response to interferon alpha", "Response to interferon beta", "Response to interferon gamma", "Response to interleukin 1", "Response to interleukin 12", "Response to interleukin 17", "Response to interleukin 3", "Response to interleukin 4", "Response to interleukin 6", "Response to interleukin 7", "Response to ionizing radiation", "Response to iron ii ion", "Response to iron ion", "Response to ischemia", "Response to isoquinoline alkaloid", "Response to ketone", "Response to l ascorbic acid", "Response to l glutamate", "Response to l phenylalanine derivative", "Response to lead ion", "Response to lectin", "Response to leptin", "Response to leucine", "Response to leukemia inhibitory factor", "Response to light intensity", "Response to light stimulus", "Response to lipid", "Response to lipoteichoic acid", "Response to lithium ion", "Response to magnesium ion", "Response to manganese ion", "Response to mechanical stimulus", "Response to mercury ion", "Response to metal ion", "Response to methylmercury", "Response to mineralocorticoid", "Response to misfolded protein", "Response to mitochondrial depolarisation", "Response to molecule of bacterial origin", "Response to monosaccharide", "Response to muramyl dipeptide", "Response to muscle activity", "Response to muscle stretch", "Response to nerve growth factor", "Response to nicotine", "Response to nitric oxide", "Response to nitrogen compound", "Response to nitrosative stress", "Response to nutrient", "Response to oleic acid", "Response to organic cyclic compound", "Response to osmotic stress", "Response to oxidative stress", "Response to oxygen containing compound", "Response to oxygen glucose deprivation", "Response to oxygen levels", "Response to oxygen radical", "Response to pain", "Response to parathyroid hormone", "Response to peptide", "Response to peptide hormone", "Response to peptidoglycan", "Response to ph", "Response to phorbol 13 acetate 12 myristate", "Response to platelet derived growth factor", "Response to potassium ion", "Response to progesterone", "Response to prostaglandin", "Response to prostaglandin e", "Response to purine containing compound", "Response to radiation", "Response to reactive oxygen species", "Response to redox state", "Response to retinoic acid", "Response to salt", "Response to salt stress", "Response to selenium ion", "Response to sodium arsenite", "Response to sorbitol", "Response to starvation", "Response to steroid hormone", "Response to sterol", "Response to sterol depletion", "Response to temperature stimulus", "Response to testosterone", "Response to thyroglobulin triiodothyronine", "Response to thyroid hormone", "Response to thyroxine", "Response to topologically incorrect protein", "Response to toxic substance", "Response to transforming growth factor beta", "Response to tumor cell", "Response to tumor necrosis factor", "Response to type i interferon", "Response to uv", "Response to uv a", "Response to uv b", "Response to uv c", "Response to virus", "Response to vitamin", "Response to vitamin a", "Response to vitamin d", "Response to vitamin k", "Response to water", "Response to wounding", "Response to x ray", "Response to xenobiotic stimulus", "Response to yeast", "Response to zinc ion", "Reticulophagy", "Retina development in camera type eye", "Retina homeostasis", "Retina layer formation", "Retina morphogenesis in camera type eye", "Retina vasculature development in camera type eye", "Retina vasculature morphogenesis in camera type eye", "Retinal cell apoptotic process", "Retinal cone cell differentiation", "Retinal ganglion cell axon guidance", "Retinal metabolic process", "Retinal rod cell development", "Retinal rod cell differentiation", "Retinoic acid metabolic process", "Retinoic acid receptor signaling pathway", "Retinol metabolic process", "Retrograde axonal transport", "Retrograde trans synaptic signaling", "Retrograde trans synaptic signaling by lipid", "Retrograde transport endosome to golgi", "Retrograde transport vesicle recycling within golgi", "Retrograde vesicle mediated transport golgi to endoplasmic reticulum", "Reverse cholesterol transport", "Reversible differentiation", "Rho protein signal transduction", "Rhodopsin mediated signaling pathway", "Rhythmic behavior", "Rhythmic process", "Riboflavin metabolic process", "Ribonucleoprotein complex biogenesis", "Ribonucleoprotein complex disassembly", "Ribonucleoprotein complex localization", "Ribonucleoprotein complex subunit organization", "Ribonucleoside catabolic process", "Ribonucleoside diphosphate biosynthetic process", "Ribonucleoside diphosphate catabolic process", "Ribonucleoside diphosphate metabolic process", "Ribonucleoside metabolic process", "Ribonucleoside monophosphate biosynthetic process", "Ribonucleoside monophosphate catabolic process", "Ribonucleoside monophosphate metabolic process", "Ribonucleoside triphosphate biosynthetic process", "Ribonucleoside triphosphate metabolic process", "Ribonucleotide catabolic process", "Ribose phosphate biosynthetic process", "Ribose phosphate metabolic process", "Ribosomal large subunit assembly", "Ribosomal large subunit biogenesis", "Ribosomal large subunit export from nucleus", "Ribosomal small subunit assembly", "Ribosomal small subunit biogenesis", "Ribosomal small subunit export from nucleus", "Ribosomal subunit export from nucleus", "Ribosome assembly", "Ribosome associated ubiquitin dependent protein catabolic process", "Ribosome biogenesis", "Ribosome disassembly", "Rig i signaling pathway", "Righting reflex", "Rna 3 end processing", "Rna 3 uridylation", "Rna 5 end processing", "Rna capping", "Rna catabolic process", "Rna decapping", "Rna dependent dna biosynthetic process", "Rna destabilization", "Rna export from nucleus", "Rna guanine n7 methylation", "Rna import into mitochondrion", "Rna interference", "Rna localization", "Rna mediated gene silencing by inhibition of translation", "Rna methylation", "Rna modification", "Rna phosphodiester bond hydrolysis", "Rna phosphodiester bond hydrolysis endonucleolytic", "Rna phosphodiester bond hydrolysis exonucleolytic", "Rna polyadenylation", "Rna polymerase i preinitiation complex assembly", "Rna polymerase ii preinitiation complex assembly", "Rna processing", "Rna secondary structure unwinding", "Rna splicing", "Rna splicing via endonucleolytic cleavage and ligation", "Rna splicing via transesterification reactions", "Rna stabilization", "Rna surveillance", "Roof of mouth development", "Rostrocaudal neural tube patterning", "Roundabout signaling pathway", "Rrna 3 end processing", "Rrna 5 end processing", "Rrna base methylation", "Rrna catabolic process", "Rrna metabolic process", "Rrna methylation", "Rrna modification", "Rrna pseudouridine synthesis", "Rrna transcription", "Rrna transport", "Ruffle assembly", "Ruffle organization", "S adenosylmethionine cycle", "S adenosylmethionine metabolic process", "Salivary gland development", "Sarcomere organization", "Sarcoplasmic reticulum calcium ion transport", "Satellite cell activation involved in skeletal muscle regeneration", "Scarna localization to cajal body", "Scf dependent proteasomal ubiquitin dependent protein catabolic process", "Schwann cell development", "Schwann cell differentiation", "Schwann cell proliferation", "Sebaceous gland development", "Second messenger mediated signaling", "Secondary alcohol metabolic process", "Secondary heart field specification", "Secondary metabolic process", "Secondary metabolite biosynthetic process", "Secondary palate development", "Secretion", "Secretion by tissue", "Secretion of lysosomal enzymes", "Secretory granule localization", "Secretory granule organization", "Segment specification", "Segmentation", "Selective autophagy", "Self proteolysis", "Semaphorin plexin signaling pathway", "Semaphorin plexin signaling pathway involved in neuron projection guidance", "Semi lunar valve development", "Seminiferous tubule development", "Sensory organ development", "Sensory organ morphogenesis", "Sensory perception", "Sensory perception of light stimulus", "Sensory perception of mechanical stimulus", "Sensory perception of pain", "Sensory system development", "Septum primum development", "Sequestering of actin monomers", "Sequestering of calcium ion", "Sequestering of iron ion", "Sequestering of metal ion", "Sequestering of triglyceride", "Sequestering of zinc ion", "Serine family amino acid biosynthetic process", "Serine family amino acid catabolic process", "Serine family amino acid metabolic process", "Serine phosphorylation of stat protein", "Serine transport", "Serotonin metabolic process", "Sertoli cell development", "Sertoli cell differentiation", "Sex determination", "Sex differentiation", "Short chain fatty acid catabolic process", "Short chain fatty acid metabolic process", "Short term memory", "Signal complex assembly", "Signal peptide processing", "Signal release", "Signal transduction by p53 class mediator", "Signal transduction in absence of ligand", "Signal transduction in response to dna damage", "Signal transduction involved in regulation of gene expression", "Signaling receptor ligand precursor processing", "Single fertilization", "Single strand break repair", "Single stranded viral rna replication via double stranded dna intermediate", "Sister chromatid cohesion", "Sister chromatid segregation", "Skeletal muscle acetylcholine gated channel clustering", "Skeletal muscle adaptation", "Skeletal muscle cell differentiation", "Skeletal muscle cell proliferation", "Skeletal muscle contraction", "Skeletal muscle fiber differentiation", "Skeletal muscle organ development", "Skeletal muscle satellite cell activation", "Skeletal muscle tissue regeneration", "Skeletal myofibril assembly", "Skeletal system development", "Skeletal system morphogenesis", "Skin development", "Skin epidermis development", "Skin morphogenesis", "Smad protein complex assembly", "Smad protein signal transduction", "Small gtpase mediated signal transduction", "Small molecule biosynthetic process", "Small molecule catabolic process", "Small molecule metabolic process", "Small nucleolar ribonucleoprotein complex assembly", "Small rna loading onto risc", "Smooth muscle adaptation", "Smooth muscle cell apoptotic process", "Smooth muscle cell chemotaxis", "Smooth muscle cell differentiation", "Smooth muscle cell migration", "Smooth muscle cell proliferation", "Smooth muscle contraction", "Smooth muscle tissue development", "Smoothened signaling pathway", "Smoothened signaling pathway involved in dorsal ventral neural tube patterning", "Snare complex assembly", "Sno s rna metabolic process", "Sno s rna processing", "Snorna localization", "Snrna metabolic process", "Snrna modification", "Snrna processing", "Snrna transcription", "Snrna transcription by rna polymerase ii", "Snrna transcription by rna polymerase iii", "Snrna transport", "Sodium independent organic anion transport", "Sodium ion export across plasma membrane", "Sodium ion homeostasis", "Sodium ion import across plasma membrane", "Sodium ion transmembrane transport", "Sodium ion transport", "Somatic diversification of immune receptors", "Somatic diversification of immune receptors via somatic mutation", "Somatic diversification of immunoglobulins", "Somatic diversification of immunoglobulins involved in immune response", "Somatic diversification of t cell receptor genes", "Somatic stem cell population maintenance", "Somite development", "Somite rostral caudal axis specification", "Somitogenesis", "Specification of animal organ identity", "Specification of symmetry", "Sperm capacitation", "Sperm dna condensation", "Sperm egg recognition", "Sperm motility", "Spermatid differentiation", "Spermatid nucleus differentiation", "Spermatogenesis exchange of chromosomal proteins", "Spermidine metabolic process", "Spermine metabolic process", "Sphingoid metabolic process", "Sphingolipid biosynthetic process", "Sphingolipid mediated signaling pathway", "Sphingolipid metabolic process", "Sphingolipid translocation", "Sphingomyelin biosynthetic process", "Sphingomyelin catabolic process", "Sphingomyelin metabolic process", "Sphingosine biosynthetic process", "Spinal cord development", "Spinal cord motor neuron differentiation", "Spindle assembly", "Spindle assembly involved in female meiosis", "Spindle elongation", "Spindle localization", "Spindle midzone assembly", "Spindle organization", "Spleen development", "Spliceosomal complex assembly", "Spliceosomal conformational changes to generate catalytic conformation", "Spliceosomal snrnp assembly", "Spliceosomal tri snrnp complex assembly", "Spontaneous synaptic transmission", "Sprouting angiogenesis", "Srp dependent cotranslational protein targeting to membrane", "Srp dependent cotranslational protein targeting to membrane signal sequence recognition", "Srp dependent cotranslational protein targeting to membrane translocation", "Startle response", "Stem cell differentiation", "Stem cell division", "Stem cell proliferation", "Steroid biosynthetic process", "Steroid catabolic process", "Steroid esterification", "Steroid hormone biosynthetic process", "Steroid hormone mediated signaling pathway", "Steroid hormone secretion", "Steroid metabolic process", "Sterol biosynthetic process", "Sterol homeostasis", "Sterol import", "Sterol metabolic process", "Sterol transport", "Stress activated protein kinase signaling cascade", "Stress fiber assembly", "Stress granule assembly", "Stress granule disassembly", "Stress induced premature senescence", "Stress response to metal ion", "Striated muscle adaptation", "Striated muscle cell apoptotic process", "Striated muscle cell development", "Striated muscle cell differentiation", "Striated muscle cell proliferation", "Striated muscle contraction", "Striatum development", "Subpallium development", "Substantia nigra development", "Substrate adhesion dependent cell spreading", "Substrate dependent cell migration", "Substrate dependent cell migration cell extension", "Substrate independent telencephalic tangential migration", "Subtelomeric heterochromatin assembly", "Succinate metabolic process", "Succinate transmembrane transport", "Succinyl coa metabolic process", "Suckling behavior", "Sugar mediated signaling pathway", "Sulfate transport", "Sulfur amino acid biosynthetic process", "Sulfur amino acid catabolic process", "Sulfur amino acid metabolic process", "Sulfur compound biosynthetic process", "Sulfur compound catabolic process", "Sulfur compound metabolic process", "Sulfur compound transport", "Superoxide anion generation", "Superoxide metabolic process", "Suppression of viral release by host", "Supramolecular fiber organization", "Sympathetic ganglion development", "Sympathetic nervous system development", "Synapse assembly", "Synapse maturation", "Synapse organization", "Synapse pruning", "Synaptic assembly at neuromuscular junction", "Synaptic membrane adhesion", "Synaptic signaling", "Synaptic transmission dopaminergic", "Synaptic transmission gabaergic", "Synaptic transmission glutamatergic", "Synaptic vesicle budding", "Synaptic vesicle clustering", "Synaptic vesicle cytoskeletal transport", "Synaptic vesicle docking", "Synaptic vesicle endosomal processing", "Synaptic vesicle exocytosis", "Synaptic vesicle localization", "Synaptic vesicle maturation", "Synaptic vesicle membrane organization", "Synaptic vesicle priming", "Synaptic vesicle recycling", "Synaptic vesicle recycling via endosome", "Synaptic vesicle transport", "Synaptic vesicle uncoating", "Synaptonemal complex organization", "Syncytium formation", "T cell activation", "T cell activation involved in immune response", "T cell activation via t cell receptor contact with antigen bound to mhc molecule on antigen presenting cell", "T cell apoptotic process", "T cell chemotaxis", "T cell cytokine production", "T cell differentiation", "T cell differentiation in thymus", "T cell differentiation involved in immune response", "T cell extravasation", "T cell homeostasis", "T cell lineage commitment", "T cell mediated cytotoxicity", "T cell mediated immune response to tumor cell", "T cell mediated immunity", "T cell migration", "T cell proliferation", "T cell proliferation involved in immune response", "T cell receptor signaling pathway", "T cell selection", "T cell tolerance induction", "T helper 1 cell differentiation", "T helper 1 type immune response", "T helper 17 cell differentiation", "T helper 17 cell lineage commitment", "T helper 17 type immune response", "T helper 2 cell differentiation", "T helper cell lineage commitment", "T tubule organization", "Tail anchored membrane protein insertion into er membrane", "Tangential migration from the subventricular zone to the olfactory bulb", "Taurine transport", "Taxis", "Telencephalon development", "Telencephalon glial cell migration", "Telencephalon regionalization", "Telomerase holoenzyme complex assembly", "Telomerase rna localization", "Telomere capping", "Telomere maintenance", "Telomere maintenance in response to dna damage", "Telomere maintenance via recombination", "Telomere maintenance via semi conservative replication", "Telomere maintenance via telomere lengthening", "Telomere organization", "Telomeric d loop disassembly", "Telomeric loop disassembly", "Temperature homeostasis", "Terminal button organization", "Termination of rna polymerase ii transcription", "Terpenoid biosynthetic process", "Terpenoid metabolic process", "Tertiary alcohol metabolic process", "Tetrahydrobiopterin metabolic process", "Tetrahydrofolate biosynthetic process", "Tetrahydrofolate interconversion", "Tetrahydrofolate metabolic process", "Tetrapyrrole biosynthetic process", "Tetrapyrrole catabolic process", "Tetrapyrrole metabolic process", "Thalamus development", "Thiamine containing compound metabolic process", "Thiamine transport", "Thioester biosynthetic process", "Thioester metabolic process", "Thorax and anterior abdomen determination", "Threonine catabolic process", "Threonine metabolic process", "Thrombin activated receptor signaling pathway", "Thrombopoietin mediated signaling pathway", "Thymocyte apoptotic process", "Thymus development", "Thyroid gland development", "Thyroid hormone mediated signaling pathway", "Tight junction organization", "Tissue development", "Tissue migration", "Tissue morphogenesis", "Tissue regeneration", "Tissue remodeling", "Tolerance induction", "Tolerance induction to self antigen", "Toll like receptor 2 signaling pathway", "Toll like receptor 3 signaling pathway", "Toll like receptor 4 signaling pathway", "Toll like receptor 7 signaling pathway", "Toll like receptor 8 signaling pathway", "Toll like receptor 9 signaling pathway", "Toll like receptor signaling pathway", "Tongue development", "Tongue morphogenesis", "Tooth mineralization", "Tor signaling", "Torc1 signaling", "Torc2 signaling", "Toxin metabolic process", "Toxin transport", "Trabecula morphogenesis", "Trachea development", "Trachea formation", "Trachea morphogenesis", "Trail activated apoptotic signaling pathway", "Trans synaptic signaling by lipid", "Trans synaptic signaling by trans synaptic complex", "Transcription by rna polymerase i", "Transcription by rna polymerase iii", "Transcription coupled nucleotide excision repair", "Transcription dependent tethering of rna polymerase ii gene dna at nuclear periphery", "Transcription elongation from rna polymerase i promoter", "Transcription elongation from rna polymerase ii promoter", "Transcription factor catabolic process", "Transcription initiation from rna polymerase i promoter", "Transcription initiation from rna polymerase ii promoter", "Transcription initiation from rna polymerase iii promoter", "Transcription preinitiation complex assembly", "Transcytosis", "Transdifferentiation", "Transepithelial chloride transport", "Transepithelial transport", "Transferrin transport", "Transforming growth factor beta activation", "Transforming growth factor beta production", "Transforming growth factor beta receptor signaling pathway", "Transforming growth factor beta1 production", "Transition between fast and slow fiber", "Transition metal ion homeostasis", "Transition metal ion transport", "Translational elongation", "Translational initiation", "Translational readthrough", "Translational termination", "Translesion synthesis", "Translocation of molecules into host", "Transmembrane receptor protein serine threonine kinase signaling pathway", "Transmembrane receptor protein tyrosine kinase signaling pathway", "Transmembrane receptor protein tyrosine phosphatase signaling pathway", "Transmembrane transport", "Transmission of nerve impulse", "Transport along microtubule", "Transport of virus", "Transposition", "Transposition rna mediated", "Tricarboxylic acid cycle", "Tricarboxylic acid metabolic process", "Trigeminal ganglion development", "Trigeminal nerve development", "Trigeminal nerve morphogenesis", "Triglyceride biosynthetic process", "Triglyceride catabolic process", "Triglyceride metabolic process", "Tripartite regional subdivision", "Tripeptide transmembrane transport", "Tripeptide transport", "Trivalent inorganic anion homeostasis", "Trna 3 end processing", "Trna 5 end processing", "Trna 5 leader removal", "Trna aminoacylation for mitochondrial protein translation", "Trna catabolic process", "Trna metabolic process", "Trna methylation", "Trna modification", "Trna processing", "Trna pseudouridine synthesis", "Trna thio modification", "Trna threonylcarbamoyladenosine metabolic process", "Trna transcription", "Trna transport", "Trna wobble base modification", "Trna wobble uridine modification", "Trophectodermal cell differentiation", "Trophoblast cell migration", "Trophoblast giant cell differentiation", "Tryptophan transport", "Tube development", "Tube formation", "Tube morphogenesis", "Tubulin complex assembly", "Tubulin deacetylation", "Tumor necrosis factor mediated signaling pathway", "Tumor necrosis factor superfamily cytokine production", "Type 2 immune response", "Type b pancreatic cell apoptotic process", "Type b pancreatic cell development", "Type i interferon production", "Type i pneumocyte differentiation", "Tyrosine catabolic process", "Tyrosine metabolic process", "Tyrosine phosphorylation of stat protein", "U4 snrna 3 end processing", "Ubiquinone metabolic process", "Ubiquitin dependent endocytosis", "Ubiquitin dependent erad pathway", "Ubiquitin dependent protein catabolic process via the multivesicular body sorting pathway", "Ubiquitin dependent smad protein catabolic process", "Ubiquitin independent protein catabolic process via the multivesicular body sorting pathway", "Ubiquitin recycling", "Udp glucose metabolic process", "Udp n acetylglucosamine biosynthetic process", "Udp n acetylglucosamine metabolic process", "Ump biosynthetic process", "Unsaturated fatty acid biosynthetic process", "Unsaturated fatty acid metabolic process", "Urate metabolic process", "Urate transport", "Urea cycle", "Urea metabolic process", "Ureter development", "Urinary bladder smooth muscle contraction", "Urinary tract smooth muscle contraction", "Urogenital system development", "Uronic acid metabolic process", "Uterine smooth muscle contraction", "Uterus development", "Uterus morphogenesis", "Utp biosynthetic process", "Utp metabolic process", "Uv damage excision repair", "Uv protection", "V d j recombination", "Vacuolar acidification", "Vacuolar localization", "Vacuolar proton transporting v type atpase complex assembly", "Vacuolar transport", "Vacuole organization", "Valine metabolic process", "Vascular associated smooth muscle cell apoptotic process", "Vascular associated smooth muscle cell differentiation", "Vascular associated smooth muscle cell migration", "Vascular associated smooth muscle cell proliferation", "Vascular associated smooth muscle contraction", "Vascular endothelial cell proliferation", "Vascular endothelial growth factor production", "Vascular endothelial growth factor receptor 2 signaling pathway", "Vascular endothelial growth factor receptor signaling pathway", "Vascular endothelial growth factor signaling pathway", "Vascular process in circulatory system", "Vascular transport", "Vascular wound healing", "Vasculature development", "Vasculogenesis", "Vasoconstriction", "Vasodilation", "Ventral spinal cord development", "Ventricular cardiac muscle cell action potential", "Ventricular cardiac muscle cell development", "Ventricular cardiac muscle cell differentiation", "Ventricular cardiac muscle cell membrane repolarization", "Ventricular cardiac muscle tissue development", "Ventricular cardiac muscle tissue morphogenesis", "Ventricular compact myocardium morphogenesis", "Ventricular septum development", "Ventricular septum morphogenesis", "Ventricular system development", "Ventricular trabecula myocardium morphogenesis", "Very long chain fatty acid catabolic process", "Very long chain fatty acid metabolic process", "Very low density lipoprotein particle assembly", "Very low density lipoprotein particle clearance", "Vesicle budding from membrane", "Vesicle cargo loading", "Vesicle cytoskeletal trafficking", "Vesicle docking", "Vesicle docking involved in exocytosis", "Vesicle fusion to plasma membrane", "Vesicle fusion with golgi apparatus", "Vesicle localization", "Vesicle mediated transport", "Vesicle mediated transport between endosomal compartments", "Vesicle mediated transport in synapse", "Vesicle mediated transport to the plasma membrane", "Vesicle organization", "Vesicle targeting", "Vesicle targeting rough er to cis golgi", "Vesicle targeting to from or within golgi", "Vesicle tethering", "Vesicle tethering to golgi", "Vesicle transport along microtubule", "Vesicle uncoating", "Vestibulocochlear nerve development", "Vestibulocochlear nerve morphogenesis", "Viral budding", "Viral gene expression", "Viral genome replication", "Viral life cycle", "Viral process", "Viral protein processing", "Viral release from host cell", "Viral rna genome replication", "Viral transcription", "Viral translation", "Viral translational termination reinitiation", "Virion assembly", "Virion attachment to host cell", "Visual behavior", "Vitamin a metabolic process", "Vitamin b6 metabolic process", "Vitamin biosynthetic process", "Vitamin catabolic process", "Vitamin d metabolic process", "Vitamin d receptor signaling pathway", "Vitamin k metabolic process", "Vitamin metabolic process", "Vitamin transmembrane transport", "Vitamin transport", "Vocalization behavior", "Voluntary musculoskeletal movement", "Walking behavior", "Water homeostasis", "Water soluble vitamin biosynthetic process", "Water soluble vitamin metabolic process", "Water transport", "White fat cell differentiation", "Wnt protein secretion", "Wnt signaling pathway involved in heart development", "Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation", "Wound healing", "Wound healing involved in inflammatory response", "Wound healing spreading of epidermal cells", "Xenobiotic catabolic process", "Xenobiotic export", "Xenobiotic metabolic process", "Xenobiotic transmembrane transport", "Xenobiotic transport", "Xenobiotic transport across blood brain barrier", "Xenophagy", "Xmp metabolic process", "Zinc ion homeostasis", "Zinc ion import across plasma membrane", "Zinc ion transport", "Zygotic determination of anterior posterior axis embryo", "Zymogen activation", "Zymogen inhibition"], "available_proteins": ["AAAS", "AAR2", "AARS", "AARS2", "AASDHPPT", "AASS", "AATF", "ABCB1", "ABCB10", "ABCB6", "ABCB7", "ABCB8", "ABCC4", "ABCD3", "ABCE1", "ABCF1", "ABCF3", "ABHD10", "ABHD12", "ABHD14B", "ABHD6", "ABRACL", "ABRAXAS2", "ACAA1", "ACAA2", "ACACA", "ACACB", "ACAD11", "ACAD9", "ACADM", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACBD5", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT8", "ACOT9", "ACOX1", "ACOX3", "ACP1", "ACP2", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACSL6", "ACTL6A", "ACTN1", "ACTN4", "ACTR1A", "ACTR2", "ACTR3", "ACTR8", "ADA", "ADAR", "ADD1", "ADD3", "ADH5", "ADI1", "ADK", "ADNP", "ADPGK", "ADRM1", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGK", "AGL", "AGPAT1", "AGPAT5", "AGPS", "AHCTF1", "AHCY", "AHCYL1", "AHNAK", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AK3", "AK4", "AK6", "AKAP1", "AKAP8", "AKAP8L", "AKAP9", "AKR1A1", "AKR1B1", "AKR7A2", "AKT2", "ALDH18A1", "ALDH1A2", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALG1", "ALG11", "ALG5", "ALKBH5", "ALYREF", "AMOT", "ANAPC1", "ANAPC16", "ANAPC2", "ANAPC4", "ANAPC5", "ANAPC7", "ANGEL1", "ANK3", "ANKFY1", "ANKHD1", "ANKLE2", "ANKRD17", "ANLN", "ANO10", "ANO6", "ANP32A", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA4", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP1M1", "AP1S1", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "APEH", "APEX1", "API5", "APOO", "APOOL", "APP", "APPL1", "APRT", "AQR", "ARCN1", "ARF4", "ARF6", "ARFGAP1", "ARFIP1", "ARFIP2", "ARG2", "ARHGAP17", "ARHGDIA", "ARHGEF2", "ARID1A", "ARID2", "ARID3B", "ARIH2", "ARL1", "ARL2", "ARL3", "ARL6IP1", "ARL6IP5", "ARL8A", "ARMC1", "ARMC10", "ARMC6", "ARMCX3", "ARMT1", "ARPC1A", "ARPC2", "ARPC3", "ARPC4", "ARVCF", "ASAH1", "ASB6", "ASCC2", "ASCC3", "ASH2L", "ASNA1", "ASNS", "ASPH", "ASPSCR1", "ATAD1", "ATAD2", "ATAD3A", "ATAD3B", "ATAD5", "ATG3", "ATG9A", "ATIC", "ATL2", "ATP13A1", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP2B4", "ATP2C1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6AP1", "ATP6AP2", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1D", "ATP6V1E1", "ATP6V1H", "ATP7A", "ATP7B", "ATPAF1", "ATPIF1", "ATRIP", "ATXN10", "ATXN2L", "AUP1", "AURKA", "B3GALT6", "B4GAT1", "BABAM1", "BABAM2", "BAG2", "BAG3", "BAG4", "BAG5", "BAG6", "BAIAP2", "BANF1", "BAP18", "BARD1", "BASP1", "BAZ1A", "BAZ1B", "BAZ2A", "BCAP31", "BCAS2", "BCAS3", "BCCIP", "BCKDK", "BCL2L12", "BCLAF1", "BCR", "BCS1L", "BICD2", "BIRC6", "BLM", "BLMH", "BLVRA", "BMS1", "BNIP1", "BOLA2*", "BOP1", "BPNT1", "BPTF", "BRAP", "BRCA1", "BRD1", "BRD2", "BRD4", "BRIX1", "BRMS1L", "BSG", "BTAF1", "BTF3", "BUB1B", "BUB3", "BUD23", "BUD31", "BYSL", "BZW1", "BZW2", "C12orf73", "C17orf75", "C19orf70", "C1QBP", "C2CD5", "C2orf49", "C5orf51", "C9orf64", "CAB39", "CACYBP", "CAD", "CALD1", "CALR", "CAMK2G", "CAMSAP3", "CAND1", "CAND2", "CANT1", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPNS1", "CAPRIN1", "CAPZA1", "CAPZB", "CARHSP1", "CARS", "CASK", "CAST", "CBR1", "CBX1", "CBX2", "CBX3", "CBX5", "CBX8", "CC2D1A", "CCAR1", "CCAR2", "CCDC134", "CCDC22", "CCDC47", "CCDC6", "CCDC93", "CCNB1", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2AP", "CD2BP2", "CD3EAP", "CD47", "CDC123", "CDC16", "CDC23", "CDC27", "CDC37", "CDC42", "CDC5L", "CDC73", "CDCA2", "CDCA5", "CDCA7L", "CDCA8", "CDH2", "CDIPT", "CDK1", "CDK12", "CDK2", "CDK4", "CDK5", "CDK5RAP1", "CDK5RAP3", "CDK6", "CDK9", "CDKAL1", "CDKN2A", "CDKN2AIP", "CDS2", "CEBPZ", "CELF1", "CELF2", "CENPI", "CENPP", "CENPV", "CEP44", "CEP55", "CEP72", "CERS2", "CERS5", "CETN2", "CFAP20", "CFL1", "CFL2", "CHAC2", "CHAF1A", "CHAF1B", "CHAMP1", "CHCHD3", "CHD1", "CHD1L", "CHD4", "CHD8", "CHDH", "CHERP", "CHID1", "CHKA", "CHMP2B", "CHMP3", "CHMP4B", "CHMP5", "CHMP7", "CHORDC1", "CHRAC1", "CHST14", "CHTF18", "CHTOP", "CIAPIN1", "CIB1", "CIRBP", "CISD2", "CIT", "CIZ1", "CKAP2", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLASP2", "CLCC1", "CLCN3", "CLCN7", "CLGN", "CLIC1", "CLINT1", "CLN5", "CLNS1A", "CLPB", "CLPP", "CLPTM1", "CLPTM1L", "CLPX", "CLSPN", "CLTA", "CLTB", "CLTC", "CLUH", "CMAS", "CMPK1", "CMTR1", "CNDP2", "CNN2", "CNN3", "CNNM3", "CNNM4", "CNOT1", "CNOT4", "CNOT9", "CNP", "COA3", "COG2", "COG3", "COG4", "COG5", "COG6", "COG7", "COIL", "COL4A3BP", "COLEC12", "COLGALT1", "COMT", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS8", "COPZ1", "COQ8A", "COQ9", "CORO1B", "CORO1C", "CORO7", "COTL1", "COX15", "COX18", "COX2", "COX4I1", "COX5A", "COX5B", "COX6C", "COX7A2", "COX7A2L", "CPD", "CPNE1", "CPNE2", "CPNE3", "CPNE8", "CPOX", "CPSF1", "CPSF2", "CPSF3", "CPSF6", "CPSF7", "CPT1A", "CPT2", "CPVL", "CRK", "CRKL", "CRNKL1", "CRTAP", "CRYZ", "CS", "CSDE1", "CSE1L", "CSGALNACT2", "CSK", "CSNK1A1", "CSNK2A1", "CSNK2A2", "CSNK2B", "CSRP2", "CSTB", "CSTF1", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTNNA1", "CTNNAL1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTPS2", "CTR9", "CTSA", "CTSC", "CTTN", "CTTNBP2NL", "CTU2", "CUL1", "CUL2", "CUL3", "CUL4A", "CUL4B", "CUL5", "CUTA", "CWC15", "CWC22", "CWF19L1", "CXADR", "CXorf56", "CXorf57", "CYB5B", "CYB5R1", "CYB5R3", "CYC1", "CYFIP1", "CYFIP2", "CYP51A1", "DAGLB", "DAP3", "DARS", "DARS2", "DAZAP1", "DBN1", "DBNL", "DBT", "DCAF1", "DCAF13", "DCAF7", "DCAF8", "DCAKD", "DCD", "DCP1B", "DCPS", "DCTD", "DCTN1", "DCTN2", "DCTN3", "DCTPP1", "DCUN1D1", "DCUN1D5", "DCXR", "DDB1", "DDI2", "DDOST", "DDRGK1", "DDT", "DDX1", "DDX10", "DDX17", "DDX18", "DDX20", "DDX21", "DDX23", "DDX27", "DDX28", "DDX39A", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX51", "DDX52", "DDX54", "DDX56", "DDX6", "DEK", "DENND6A", "DENR", "DERL1", "DERL2", "DFFA", "DHCR24", "DHCR7", "DHFR", "DHPS", "DHRS13", "DHRS7", "DHRS7B", "DHTKD1", "DHX15", "DHX16", "DHX29", "DHX30", "DHX36", "DHX37", "DHX38", "DHX8", "DHX9", "DIAPH1", "DIAPH2", "DIAPH3", "DICER1", "DIDO1", "DIEXF", "DIMT1", "DIS3", "DKC1", "DLAT", "DLD", "DLG1", "DLGAP5", "DLST", "DMAP1", "DNA2", "DNAAF5", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC13", "DNAJC2", "DNAJC21", "DNAJC3", "DNAJC7", "DNAJC9", "DNM1L", "DNM2", "DNMT1", "DNPH1", "DNTTIP2", "DOCK7", "DOHH", "DOLPP1", "DPF2", "DPH2", "DPH5", "DPM1", "DPP3", "DPP9", "DPY30", "DPYSL2", "DPYSL3", "DPYSL5", "DRG1", "DRG2", "DSC3", "DSCR3", "DSG2", "DSP", "DST", "DSTN", "DTX3L", "DTYMK", "DUS2", "DUSP12", "DUSP3", "DUSP9", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNC2H1", "DYNLL1", "DYNLL2", "EARS2", "EBNA1BP2", "EBP", "ECE1", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "ECSIT", "EDC3", "EDC4", "EDF1", "EDRF1", "EEA1", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EFL1", "EFTUD2", "EHBP1", "EHD1", "EHD4", "EI24", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2D", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E", "EIF4E2", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAC2", "ELAVL1", "ELL", "ELMO2", "ELMOD2", "ELOA", "ELOB", "ELP1", "ELP2", "ELP3", "ELP4", "EMC1", "EMC2", "EMC7", "EMD", "EMG1", "EML4", "ENAH", "ENDOD1", "ENO1", "ENO2", "ENY2", "EP400", "EPB41", "EPB41L2", "EPB41L3", "EPB41L5", "EPDR1", "EPHA7", "EPHX1", "EPHX2", "EPN1", "EPPK1", "EPRS", "EPS15L1", "ERAL1", "ERAP1", "ERAP2", "ERBIN", "ERC1", "ERCC2", "ERCC3", "ERCC6L", "ERG28", "ERGIC1", "ERGIC3", "ERH", "ERLIN1", "ERLIN2", "ERMP1", "ERO1A", "ERO1B", "ERP29", "ESD", "ESF1", "ESYT1", "ESYT2", "ETF1", "ETFA", "ETFB", "ETFDH", "EXD2", "EXO1", "EXOC2", "EXOC3", "EXOC5", "EXOC6", "EXOC7", "EXOC8", "EXOSC1", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC8", "EXOSC9", "EYA4", "EZR", "F11R", "FADS2", "FAF1", "FAF2", "FAH", "FAM129B", "FAM162A", "FAM192A", "FAM208A", "FAM213A", "FAM49B", "FAM50A", "FAM98A", "FAM98B", "FANCD2", "FANCI", "FAR1", "FARP1", "FARP2", "FARSA", "FARSB", "FASN", "FASTKD5", "FBL", "FDFT1", "FDPS", "FDXR", "FECH", "FEN1", "FERMT2", "FGFR1OP", "FH", "FHL1", "FHOD1", "FIP1L1", "FIS1", "FKBP10", "FKBP14", "FKBP2", "FKBP3", "FKBP4", "FKBP5", "FKBP7", "FKBP8", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FMR1", "FNDC3A", "FNTA", "FNTB", "FOXC1", "FOXK1", "FOXRED1", "FRYL", "FSCN1", "FSD1", "FTO", "FTSJ3", "FUBP1", "FUBP3", "FUCA1", "FUCA2", "FUNDC2", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GADD45GIP1", "GAK", "GALK1", "GALM", "GALNT1", "GALNT2", "GALNT4", "GALNT7", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GATAD2B", "GATB", "GBA", "GBF1", "GCAT", "GCDH", "GCFC2", "GCLC", "GCN1", "GDAP1", "GDI1", "GDI2", "GDPD1", "GEMIN4", "GEMIN5", "GEMIN8", "GET4", "GFM1", "GFPT1", "GGA1", "GGCT", "GGCX", "GGH", "GGT7", "GHITM", "GID4", "GIGYF2", "GINS2", "GINS3", "GINS4", "GLA", "GLB1", "GLCE", "GLDC", "GLE1", "GLG1", "GLMN", "GLO1", "GLRX3", "GLRX5", "GLS", "GLTP", "GLUD1", "GLYR1", "GM2A", "GMFB", "GMPS", "GNA13", "GNAI1", "GNAI2", "GNAI3", "GNAQ", "GNE", "GNG12", "GNG5", "GNL1", "GNL2", "GNL3", "GNL3L", "GNPAT", "GNPDA1", "GNPNAT1", "GNS", "GOLGA2", "GOLGA3", "GOLGA5", "GOLGB1", "GOLT1B", "GORASP2", "GOSR1", "GOT1", "GOT2", "GPAA1", "GPAM", "GPAT4", "GPATCH4", "GPD1L", "GPD2", "GPHN", "GPI", "GPKOW", "GPR107", "GPR108", "GPR89B", "GPS1", "GPT2", "GPX8", "GRB2", "GRHPR", "GRPEL1", "GRSF1", "GRWD1", "GSK3B", "GSPT1", "GSR", "GSS", "GSTK1", "GSTM3", "GSTO1", "GSTZ1", "GTF2E1", "GTF2E2", "GTF2F1", "GTF2H1", "GTF2H4", "GTF2I", "GTF3C1", "GTF3C2", "GTF3C3", "GTF3C4", "GTF3C5", "GTPBP1", "GTPBP10", "GTPBP3", "GTPBP4", "GUF1", "GXYLT1", "GYG1", "GYS1", "H1F0", "H1FX", "H2AFY", "H2AFY2", "H4C1*", "HACD3", "HACL1", "HADH", "HADHA", "HADHB", "HARS2", "HAT1", "HAUS1", "HAUS3", "HAUS4", "HAUS5", "HAUS6", "HAX1", "HBS1L", "HCCS", "HCFC1", "HDAC1", "HDAC2", "HDGF", "HDGFL2", "HDGFL3", "HDHD2", "HDHD5", "HDLBP", "HEATR1", "HEATR3", "HEBP1", "HECTD1", "HECTD3", "HELLS", "HEXA", "HEXB", "HGS", "HIBADH", "HIBCH", "HINT2", "HIRA", "HIRIP3", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLTF", "HM13", "HMBS", "HMCES", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMGCL", "HMGCR", "HMGCS1", "HMGN2", "HMOX1", "HMOX2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPLL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HOOK2", "HOOK3", "HP1BP3", "HPRT1", "HPS6", "HS2ST1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSD17B7", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA13", "HSPA14", "HSPA1B", "HSPA2", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPBP1", "HSPD1", "HSPE1", "HSPH1", "HTATSF1", "HTT", "HUWE1", "HYOU1", "IARS", "IARS2", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDH3G", "IDI1", "IFIT5", "IFT27", "IFT81", "IGBP1", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IK", "IKBIP", "IKBKB", "ILF2", "ILF3", "ILK", "ILKAP", "ILVBL", "IMMT", "IMP3", "IMP4", "IMPAD1", "IMPDH1", "IMPDH2", "INA", "INF2", "INPP4A", "INPPL1", "INTS1", "INTS11", "INTS14", "INTS2", "INTS3", "INTS4", "INTS7", "INTS8", "INTS9", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQCB1", "IQGAP1", "IQGAP3", "IRF2BPL", "IRS4", "ISG20L2", "IST1", "ISY1", "ISYNA1", "ITCH", "ITGB1", "ITM2C", "ITPA", "ITPK1", "ITSN2", "IVD", "IWS1", "JAGN1", "JMJD6", "JUP", "KARS", "KAT7", "KCTD12", "KDELC2", "KDELR1", "KDM1A", "KDM1B", "KDM2A", "KDM3B", "KDM5A", "KDSR", "KHDRBS1", "KHDRBS3", "KHSRP", "KIAA0368", "KIAA0391", "KIAA1468", "KIDINS220", "KIF11", "KIF14", "KIF18A", "KIF18B", "KIF1A", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF3A", "KIF4A", "KIF5B", "KIFBP", "KIN", "KLC1", "KMT2A", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNA6", "KPNB1", "KRI1", "KRR1", "KTN1", "KYAT3", "L2HGDH", "LACTB", "LAMB1", "LAMC1", "LAMP1", "LAMP2", "LAMTOR1", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LAS1L", "LASP1", "LBR", "LCLAT1", "LDAH", "LDHA", "LDHB", "LDLR", "LEMD3", "LETM1", "LGALS3", "LGALS3BP", "LGMN", "LIG1", "LIG3", "LIMA1", "LIN9", "LIPA", "LLGL1", "LLPH", "LMAN2", "LMAN2L", "LMF2", "LMNA", "LMNB1", "LNPEP", "LNPK", "LONP1", "LPCAT1", "LPGAT1", "LRBA", "LRP1", "LRPAP1", "LRPPRC", "LRRC40", "LRRC47", "LRRC59", "LRRC8C", "LRSAM1", "LRWD1", "LSM14B", "LSM2", "LSM4", "LSM6", "LSM7", "LSS", "LTA4H", "LTN1", "LTV1", "LUC7L", "LUC7L2", "LUC7L3", "LYAR", "LYN", "LYPLA1", "LZTFL1", "M6PR", "MACF1", "MAEA", "MAGED2", "MAGT1", "MAIP1", "MAK16", "MALT1", "MAN2A1", "MAN2B1", "MANF", "MAP1A", "MAP1B", "MAP1S", "MAP4", "MAP7D1", "MAPK1", "MAPK14", "MAPRE1", "MAPRE2", "MARC1", "MARCH5", "MARS", "MARS2", "MAT2A", "MAT2B", "MATR3", "MAU2", "MAVS", "MBD3", "MBOAT7", "MCAM", "MCCC1", "MCCC2", "MCL1", "MCM10", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCMBP", "MCU", "MCUB", "MCUR1", "MDC1", "MDH1", "MDH2", "MDN1", "ME1", "ME2", "MECP2", "MED14", "MED17", "MED23", "MED24", "MED4", "MEPCE", "MESD", "METAP1", "METAP2", "METTL13", "METTL3", "METTL7B", "METTL9", "MFN1", "MFN2", "MFSD10", "MFSD3", "MFSD5", "MGEA5", "MGST2", "MGST3", "MIA2", "MIA3", "MICU1", "MIEF1", "MIF", "MIGA1", "MINDY3", "MINPP1", "MIPEP", "MKI67", "MKLN1", "MKRN2", "MLEC", "MMAB", "MMS19", "MOCOS", "MOGS", "MON2", "MORC2", "MORF4L1", "MORF4L2", "MOSPD2", "MOV10", "MPC2", "MPG", "MPHOSPH10", "MPHOSPH6", "MPHOSPH8", "MPI", "MPP1", "MPP2", "MPP6", "MPP7", "MPRIP", "MPST", "MPV17", "MPV17L2", "MRC2", "MRE11", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL14", "MRPL15", "MRPL19", "MRPL2", "MRPL20", "MRPL22", "MRPL24", "MRPL28", "MRPL3", "MRPL37", "MRPL41", "MRPL43", "MRPL44", "MRPL47", "MRPL58", "MRPL9", "MRPS11", "MRPS16", "MRPS18A", "MRPS27", "MRPS28", "MRPS30", "MRPS33", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRRF", "MRTO4", "MSH2", "MSH3", "MSH6", "MSI1", "MSI2", "MSMO1", "MSN", "MSTO1", "MTA1", "MTA2", "MTAP", "MTBP", "MTCH1", "MTCH2", "MTDH", "MTHFD1", "MTHFD1L", "MTHFD2", "MTHFS", "MTMR14", "MTMR2", "MTMR6", "MTO1", "MTOR", "MTPAP", "MTPN", "MTR", "MTX1", "MTX2", "MTX3", "MUL1", "MUT", "MVD", "MYBBP1A", "MYCBP", "MYCBP2", "MYDGF", "MYEF2", "MYG1", "MYH10", "MYH14", "MYH9", "MYL6", "MYO18A", "MYO1B", "MYO1C", "MYO1D", "MYO6", "NAA10", "NAA15", "NAA25", "NAA35", "NAA40", "NAA50", "NAE1", "NAF1", "NAGLU", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NAPG", "NARS", "NASP", "NAT10", "NAXE", "NBAS", "NBN", "NCAPD2", "NCAPD3", "NCAPG", "NCAPG2", "NCAPH", "NCBP1", "NCBP3", "NCDN", "NCEH1", "NCKAP1", "NCKIPSD", "NCL", "NCLN", "NCOA5", "NCOR1", "NCSTN", "ND1", "NDC1", "NDC80", "NDRG3", "NDUFA10", "NDUFA11", "NDUFA13", "NDUFA4", "NDUFA5", "NDUFA7", "NDUFA8", "NDUFA9", "NDUFAF2", "NDUFAF3", "NDUFAF4", "NDUFAF7", "NDUFB10", "NDUFB3", "NDUFB4", "NDUFB5", "NDUFB6", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS6", "NDUFS7", "NDUFS8", "NDUFV1", "NDUFV2", "NECAP2", "NEDD1", "NEDD4L", "NEFL", "NEFM", "NEK9", "NELFA", "NELFB", "NELFCD", "NELFE", "NEMF", "NENF", "NES", "NF1", "NFATC2IP", "NFKBIL1", "NFS1", "NFU1", "NHP2", "NIFK", "NIP7", "NIPBL", "NIPSNAP1", "NIPSNAP2", "NISCH", "NIT2", "NKRF", "NKTR", "NLE1", "NLN", "NLRX1", "NME1", "NME2", "NMT1", "NNT", "NOA1", "NOB1", "NOC2L", "NOC3L", "NOC4L", "NOL10", "NOL11", "NOL6", "NOL8", "NOL9", "NOLC1", "NOM1", "NONO", "NOP14", "NOP16", "NOP2", "NOP53", "NOP56", "NOP58", "NOP9", "NOSIP", "NOTCH2", "NPC1", "NPC2", "NPEPPS", "NPLOC4", "NPM1", "NRBP1", "NRDC", "NRDE2", "NRP1", "NSA2", "NSD1", "NSD2", "NSD3", "NSDHL", "NSF", "NSMCE2", "NSUN2", "NT5C2", "NT5C3A", "NT5C3B", "NT5DC1", "NT5DC2", "NTHL1", "NTMT1", "NUB1", "NUBP2", "NUBPL", "NUCB1", "NUCB2", "NUCKS1", "NUDC", "NUDCD2", "NUDCD3", "NUDT1", "NUDT16L1", "NUDT21", "NUDT5", "NUF2", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP160", "NUP188", "NUP205", "NUP210", "NUP214", "NUP35", "NUP37", "NUP43", "NUP50", "NUP54", "NUP58", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NUPL2", "NUSAP1", "NUTF2", "NVL", "NXF1", "NXN", "OARD1", "OAT", "OCIAD1", "OCLN", "OCRL", "OGDH", "OGT", "OLA1", "OPA1", "OPA3", "ORC2", "ORC3", "ORC5", "OSBP", "OSBPL11", "OSBPL1A", "OSBPL6", "OSBPL8", "OSBPL9", "OSGEP", "OSTF1", "OTUB1", "OXA1L", "OXSR1", "P3H1", "P3H4", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PAF1", "PAFAH1B1", "PAFAH1B2", "PAFAH1B3", "PAICS", "PAK1IP1", "PAK2", "PALD1", "PALLD", "PANK4", "PAPOLA", "PAPSS1", "PARD3", "PARG", "PARK7", "PARN", "PARP1", "PARP2", "PATL1", "PBK", "PBRM1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCM1", "PCMT1", "PCNA", "PCYOX1", "PDCD11", "PDCD5", "PDCD6", "PDCD6IP", "PDCL3", "PDE12", "PDHA1", "PDHB", "PDHX", "PDIA3", "PDIA4", "PDIA6", "PDK1", "PDK3", "PDLIM1", "PDLIM5", "PDP1", "PDS5A", "PDS5B", "PDSS2", "PDXDC1", "PDZD8", "PEBP1", "PECR", "PEF1", "PELO", "PELP1", "PEPD", "PES1", "PEX11B", "PEX14", "PEX19", "PEX3", "PFAS", "PFDN2", "PFDN4", "PFDN5", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGM3", "PGP", "PGRMC1", "PGRMC2", "PHB", "PHB2", "PHF10", "PHF2", "PHF5A", "PHF6", "PHGDH", "PHIP", "PHKA1", "PHKB", "PI4K2A", "PI4KA", "PI4KB", "PICALM", "PIGG", "PIGK", "PIGS", "PIGT", "PIGU", "PIH1D1", "PIK3C2A", "PIK3R2", "PIK3R4", "PIN1", "PIN4", "PINX1", "PIP4K2C", "PIR", "PISD", "PITHD1", "PITPNA", "PITPNB", "PITRM1", "PKM", "PKMYT1", "PKN1", "PKN2", "PLA2G15", "PLAA", "PLBD2", "PLCG1", "PLD3", "PLD6", "PLEC", "PLEKHA5", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLRG1", "PLS3", "PLXNB2", "PM20D2", "PMPCA", "PMPCB", "PMVK", "PNKP", "PNN", "PNP", "PNPLA6", "PNPLA8", "PNPT1", "POFUT1", "POGZ", "POLA1", "POLA2", "POLD1", "POLD2", "POLDIP2", "POLDIP3", "POLE", "POLE2", "POLG", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2A", "POLR2D", "POLR2G", "POLR2L", "POLR3A", "POLR3B", "POLR3C", "POLRMT", "PON2", "POP1", "POP4", "POR", "PPA2", "PPAN", "PPAT", "PPCDC", "PPFIA1", "PPHLN1", "PPIB", "PPIC", "PPID", "PPIE", "PPIF", "PPIG", "PPIH", "PPIL4", "PPM1G", "PPME1", "PPOX", "PPP1CA", "PPP1CB", "PPP1R10", "PPP1R7", "PPP1R8", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP2R5E", "PPP3CA", "PPP4R1", "PPP4R3A", "PPP5C", "PPP6C", "PPP6R3", "PPT1", "PPWD1", "PQBP1", "PRAF2", "PRC1", "PRCC", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PREP", "PREPL", "PRIM1", "PRIM2", "PRKAA1", "PRKAA2", "PRKACA", "PRKAG1", "PRKAR1A", "PRKAR2A", "PRKCB", "PRKCSH", "PRKDC", "PRMT1", "PRMT3", "PRMT5", "PRMT9", "PRPF19", "PRPF3", "PRPF31", "PRPF38B", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPS2", "PRPSAP1", "PRPSAP2", "PRRC1", "PRRC2C", "PSAP", "PSAT1", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD6", "PSMD7", "PSMD8", "PSME1", "PSME2", "PSME3", "PSME4", "PSMG1", "PSMG2", "PSMG3", "PSPC1", "PTBP1", "PTBP2", "PTCD1", "PTCD3", "PTDSS1", "PTDSS2", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK2", "PTK7", "PTPA", "PTPN1", "PTPN11", "PTPN23", "PTPRF", "PTRH2", "PUF60", "PUM3", "PURA", "PUS1", "PUS7", "PUS7L", "PWP1", "PWP2", "PXMP2", "PXN", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QDPR", "QKI", "QRSL1", "QSOX2", "QTRT2", "RAB10", "RAB12", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB1B", "RAB23", "RAB24", "RAB2A", "RAB34", "RAB35", "RAB3B", "RAB3GAP1", "RAB3GAP2", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RAB8A", "RAB9A", "RABEPK", "RABGAP1", "RABGGTA", "RABL3", "RAC1", "RACGAP1", "RACK1", "RAD18", "RAD21", "RAD23A", "RAD23B", "RAD50", "RAD54L2", "RAE1", "RAI14", "RALA", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP6", "RANBP9", "RANGAP1", "RAP1GDS1", "RAPGEF2", "RARS", "RARS2", "RAVER1", "RBBP4", "RBBP5", "RBBP6", "RBBP7", "RBM10", "RBM12", "RBM12B", "RBM14", "RBM17", "RBM19", "RBM22", "RBM25", "RBM26", "RBM27", "RBM28", "RBM3", "RBM39", "RBM4", "RBM47", "RBM5", "RBM6", "RBM8A", "RBMX", "RBMXL1", "RBPJ", "RCC1", "RCC2", "RCL1", "RCN1", "RDH11", "RDH13", "RDH14", "RDX", "RECQL", "REEP4", "REEP5", "RER1", "RETSAT", "REXO2", "REXO4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RFT1", "RHBDD2", "RHEB", "RHOG", "RHOT1", "RHOT2", "RIDA", "RIF1", "RINT1", "RIPK1", "RMDN1", "RMDN3", "RNASEH2A", "RNASET2", "RNF2", "RNF20", "RNF40", "RNMT", "RNPEP", "RNPS1", "ROBO1", "ROCK1", "ROCK2", "RP2", "RPA1", "RPA2", "RPF1", "RPF2", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPN1", "RPN2", "RPP30", "RPP38", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS26", "RPS28", "RPS29", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RPTOR", "RPUSD3", "RRAS2", "RRBP1", "RREB1", "RRM1", "RRM2", "RRP1", "RRP12", "RRP15", "RRP1B", "RRP36", "RRP8", "RRP9", "RRS1", "RSBN1", "RSF1", "RSL1D1", "RSL24D1", "RSPRY1", "RSU1", "RTCA", "RTCB", "RTFDC1", "RTN1", "RTN2", "RTN3", "RTN4", "RTN4IP1", "RTRAF", "RUFY1", "RUVBL1", "RUVBL2", "S100A11", "S100A13", "SAAL1", "SACM1L", "SAE1", "SAFB", "SAFB2", "SALL2", "SAMD4B", "SAMHD1", "SAMM50", "SAP130", "SAP18", "SAP30BP", "SAR1A", "SAR1B", "SARM1", "SARNP", "SARS", "SARS2", "SART1", "SART3", "SBDS", "SCAF1", "SCAF11", "SCAF4", "SCAMP1", "SCAMP2", "SCAMP3", "SCAMP4", "SCARB1", "SCARB2", "SCCPDH", "SCD", "SCFD1", "SCFD2", "SCML2", "SCO1", "SCO2", "SCP2", "SCPEP1", "SCRIB", "SCRN1", "SCYL1", "SDAD1", "SDF4", "SDHA", "SDHB", "SDHC", "SEC11A", "SEC16A", "SEC22B", "SEC23A", "SEC23B", "SEC23IP", "SEC24A", "SEC24B", "SEC24C", "SEC31A", "SEC61A1", "SEC61B", "SEC62", "SEC63", "SEH1L", "SEL1L", "SENP3", "SEPT11", "SEPT2", "SEPT7", "SEPT9", "SERBP1", "SERPINB6", "SERPINH1", "SET", "SETD1A", "SETD2", "SETD3", "SETDB1", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFSWAP", "SFXN1", "SFXN2", "SFXN4", "SGF29", "SGPL1", "SGTA", "SH3GL1", "SH3GLB1", "SHCBP1", "SHMT1", "SHMT2", "SHTN1", "SIGMAR1", "SIN3A", "SKA1", "SKA3", "SKIV2L", "SKIV2L2", "SKP1", "SKP2", "SLC12A2", "SLC12A9", "SLC16A1", "SLC19A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A16", "SLC25A17", "SLC25A19", "SLC25A20", "SLC25A21", "SLC25A24", "SLC25A25", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A33", "SLC25A4", "SLC25A44", "SLC25A5", "SLC25A6", "SLC27A4", "SLC33A1", "SLC35A4", "SLC35B2", "SLC35F2", "SLC39A14", "SLC3A2", "SLC4A2", "SLC5A6", "SLC7A1", "SLC9A3R1", "SLFN11", "SLIRP", "SLIT2", "SLK", "SLMAP", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC5", "SMC6", "SMCHD1", "SMG1", "SMG5", "SMN1*", "SMNDC1", "SMPD4", "SMS", "SMU1", "SND1", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPC", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNU13", "SNW1", "SNX1", "SNX17", "SNX19", "SNX2", "SNX27", "SNX3", "SNX5", "SNX6", "SNX9", "SOAT1", "SOD2", "SON", "SORD", "SORT1", "SPAG5", "SPAG9", "SPART", "SPATA5", "SPC25", "SPCS2", "SPCS3", "SPDL1", "SPECC1L", "SPEN", "SPNS1", "SPOUT1", "SPPL2A", "SPR", "SPTAN1", "SPTBN1", "SPTLC1", "SPTLC2", "SQLE", "SRC", "SRCAP", "SREK1", "SRI", "SRM", "SRP14", "SRP54", "SRP68", "SRP72", "SRP9", "SRPK1", "SRPK2", "SRPRA", "SRPRB", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF3", "SRSF4", "SRSF5", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSR1", "SSRP1", "STAG1", "STAG2", "STAM", "STAM2", "STAT1", "STAT3", "STAU1", "STAU2", "STIP1", "STK26", "STK3", "STK4", "STMN1", "STOM", "STOML2", "STRAP", "STRBP", "STRIP1", "STRN", "STT3A", "STT3B", "STUB1", "STX10", "STX12", "STX16", "STX18", "STX4", "STX7", "STX8", "STXBP2", "STXBP3", "STXBP4", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGP2", "SUGT1", "SUN1", "SUN2", "SUPT16H", "SUPT3H", "SUPT5H", "SUPT6H", "SUPV3L1", "SURF6", "SUZ12", "SV2A", "SYAP1", "SYMPK", "SYNCRIP", "SYNE1", "SYNE2", "SYNGR2", "SYNJ2BP", "SYS1", "TAB1", "TACC3", "TAF15", "TAF6", "TAGLN2", "TALDO1", "TAMM41", "TAP1", "TAP2", "TARBP1", "TARDBP", "TARS", "TARS2", "TARSL2", "TBC1D13", "TBC1D15", "TBC1D4", "TBC1D9B", "TBCA", "TBCD", "TBCE", "TBL1XR1", "TBL2", "TBL3", "TBRG4", "TCAF1", "TCEA1", "TCERG1", "TCOF1", "TCP1", "TDRKH", "TECR", "TEFM", "TELO2", "TERF2IP", "TES", "TEX264", "TFAM", "TFB1M", "TFCP2", "TFG", "TFIP11", "TFRC", "TGFBRAP1", "THADA", "THAP11", "THOC1", "THOC2", "THOC3", "THOC5", "THOC6", "THOP1", "THRAP3", "THUMPD1", "TIA1", "TIAL1", "TIGAR", "TIMM10B", "TIMM17B", "TIMM23", "TIMM44", "TIMM50", "TIMM8B", "TJP1", "TJP2", "TK1", "TKT", "TLCD1", "TLE3", "TLK2", "TLN1", "TM9SF2", "TM9SF3", "TM9SF4", "TMCO1", "TMED10", "TMED2", "TMED7", "TMED9", "TMEM109", "TMEM11", "TMEM115", "TMEM126A", "TMEM14C", "TMEM161A", "TMEM167A", "TMEM199", "TMEM201", "TMEM214", "TMEM230", "TMEM259", "TMEM33", "TMEM43", "TMEM65", "TMEM87A", "TMEM97", "TMLHE", "TMOD3", "TMTC3", "TMX1", "TMX2", "TMX3", "TNKS1BP1", "TNPO1", "TNPO2", "TNPO3", "TOE1", "TOMM20", "TOMM22", "TOMM34", "TOMM40", "TOMM5", "TOMM70", "TOP1", "TOP2A", "TOP2B", "TOPBP1", "TOR1A", "TOR1AIP1", "TOR1AIP2", "TOR1B", "TP53", "TP53BP1", "TP53BP2", "TPBG", "TPD52", "TPD52L2", "TPI1", "TPM3", "TPM4", "TPP1", "TPP2", "TPR", "TPT1", "TPX2", "TRA2A", "TRA2B", "TRAF2", "TRAP1", "TRAPPC11", "TRAPPC4", "TRAPPC5", "TRIM13", "TRIM21", "TRIM25", "TRIM26", "TRIM27", "TRIM28", "TRIM33", "TRIM4", "TRIO", "TRIP12", "TRIP13", "TRIP4", "TRIR", "TRMT1", "TRMT10C", "TRMT11", "TRMT1L", "TRMT2A", "TRMT6", "TRMU", "TROVE2", "TRRAP", "TRUB1", "TSFM", "TSG101", "TSN", "TSNAX", "TSPAN6", "TSPO", "TSR1", "TST", "TTC1", "TTC19", "TTC26", "TTC28", "TTC37", "TTC4", "TTF2", "TTK", "TTLL12", "TTYH3", "TUBB", "TUBB2A", "TUBB2B", "TUBB3", "TUBB4A", "TUBB6", "TUBGCP2", "TUBGCP3", "TUFM", "TWF2", "TWNK", "TXLNA", "TXLNG", "TXNDC12", "TXNDC15", "TXNDC17", "TXNDC5", "TXNDC9", "TXNRD1", "TYMS", "U2AF1", "U2AF2", "U2SURP", "UAP1", "UBA1", "UBA2", "UBA3", "UBA6", "UBAC1", "UBAP2L", "UBE2J1", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2O", "UBE2S", "UBE3A", "UBE3C", "UBE4A", "UBLCP1", "UBQLN4", "UBR2", "UBR4", "UBR5", "UBTF", "UBXN1", "UBXN4", "UBXN7", "UCHL5", "UCK2", "UFC1", "UFD1", "UFL1", "UFM1", "UGCG", "UGDH", "UGGT1", "UGP2", "UGT8", "UHRF1", "UMPS", "UNC45A", "UPF1", "UPF2", "UPF3B", "UQCC2", "UQCR10", "UQCRB", "UQCRC1", "UQCRC2", "UQCRFS1", "UQCRQ", "URB1", "URGCP", "UROD", "USO1", "USP10", "USP11", "USP14", "USP19", "USP24", "USP28", "USP36", "USP39", "USP47", "USP48", "USP5", "USP7", "USP9X", "UTP11", "UTP14A", "UTP15", "UTP18", "UTP20", "UTP3", "UTP4", "UTP6", "UTRN", "VAMP7", "VANGL1", "VANGL2", "VAPA", "VAPB", "VARS1", "VARS2", "VAT1", "VBP1", "VCL", "VCP", "VDAC1", "VDAC2", "VDAC3", "VIM", "VIPAS39", "VIRMA", "VPS13A", "VPS13C", "VPS16", "VPS18", "VPS26A", "VPS29", "VPS33A", "VPS33B", "VPS35", "VPS37B", "VPS45", "VPS4A", "VPS4B", "VPS50", "VPS51", "VPS52", "VPS53", "VRK1", "VRK3", "VTA1", "WAPL", "WARS", "WASHC4", "WASHC5", "WBP11", "WBP2", "WDHD1", "WDR1", "WDR11", "WDR12", "WDR18", "WDR26", "WDR3", "WDR33", "WDR36", "WDR4", "WDR41", "WDR43", "WDR46", "WDR5", "WDR6", "WDR61", "WDR7", "WDR73", "WDR74", "WDR75", "WDR77", "WDR82", "WDR91", "WFS1", "WIPI2", "WIZ", "WLS", "WRAP73", "WRNIP1", "WTAP", "XAB2", "XPNPEP1", "XPNPEP3", "XPO1", "XPO4", "XPO5", "XPO7", "XPOT", "XRCC1", "XRCC5", "XRCC6", "XRN2", "XXYLT1", "YARS", "YARS2", "YEATS2", "YEATS4", "YIF1A", "YKT6", "YLPM1", "YME1L1", "YOD1", "YTHDC1", "YTHDC2", "YTHDF2", "YTHDF3", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2", "ZC3H11A", "ZC3H14", "ZC3H15", "ZC3H18", "ZC3H4", "ZC3H7A", "ZC3HAV1", "ZCCHC11", "ZCCHC3", "ZCCHC8", "ZFYVE16", "ZMPSTE24", "ZMYM4", "ZNF281", "ZNF318", "ZNF326", "ZNF512B", "ZNF598", "ZNF622", "ZNF638", "ZPR1", "ZRANB2", "ZW10", "ZWILCH", "ZYX", "ZZEF1"], "leading_proteins": ["AASDHPPT", "ABCB1", "ABCB10", "ABCB6", "ABCB7", "ABCB8", "ABCD3", "ABHD10", "ABHD12", "ACBD5", "ACOX3", "ACP2", "ACP6", "ACSL1", "ACSL6", "ACTN4", "ADD1", "ADPGK", "AFG3L2", "AGK", "AGL", "AGPAT5", "AGPS", "AIFM1", "AK3", "AKAP8L", "AKT2", "ALDH18A1", "ALDH3A2", "ALG1", "ALG11", "ANK3", "ANKLE2", "ANO10", "ANO6", "ANXA1", "ANXA7", "AP3B1", "APOO", "APOOL", "APP", "APPL1", "ARG2", "ARHGAP17", "ARL6IP1", "ARL6IP5", "ARMC1", "ARMC10", "ASAH1", "ASNA1", "ASPH", "ATAD1", "ATAD3A", "ATAD3B", "ATG9A", "ATL2", "ATP13A1", "ATP1A1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP2B4", "ATP2C1", "ATP5B", "ATP5F1", "ATP5I", "ATP5L", "ATP6AP1", "ATP6AP2", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1D", "ATP6V1E1", "ATP7A", "ATP7B", "B3GALT6", "B4GAT1", "BAG4", "BAG6", "BCAP31", "BCAS3", "BCCIP", "BCR", "BICD2", "BNIP1", "BRAP", "BRCA1", "BSG", "BUB1B", "C12orf73", "C19orf70", "C1QBP", "CANX", "CAPNS1", "CASK", "CCDC47", "CCDC93", "CCNB1", "CD47", "CDC37", "CDC42", "CDIPT", "CDK1", "CDK5RAP1", "CDS2", "CENPP", "CERS2", "CERS5", "CETN2", "CHCHD3", "CHKA", "CHMP2B", "CHMP3", "CHST14", "CIB1", "CIT", "CLASP1", "CLASP2", "CLCC1", "CLCN3", "CLCN7", "CLN5", "CLNS1A", "CLPTM1", "CLUH", "CNNM3", "CNNM4", "COA3", "COG2", "COG5", "COG7", "COLEC12", "COMT", "COPS4", "COPS5", "COPS6", "COPS8", "COQ9", "COX15", "COX18", "COX2", "COX4I1", "COX5A", "COX7A2", "COX7A2L", "CPT1A", "CPT2", "CRK", "CRYZ", "CSGALNACT2", "CTNNB1", "CTSA", "CTSC", "CTTNBP2NL", "CUL1", "CUL5", "CXADR", "CYB5B", "CYC1", "CYP51A1", "DAGLB", "DCAKD", "DCP1B", "DCTN1", "DCTN2", "DCUN1D1", "DCUN1D5", "DDRGK1", "DERL1", "DERL2", "DHCR24", "DHCR7", "DHFR", "DHPS", "DHRS7", "DHRS7B", "DLD", "DLG1", "DNA2", "DNAJA3", "DNAJC1", "DNAJC10", "DNAJC11", "DNM1L", "DNM2", "DOLPP1", "DPF2", "DUSP9", "DYNC1LI1", "DYNC2H1", "DYNLL1", "EBP", "ECE1", "ECSIT", "EEF1A2", "EHD4", "EI24", "EIF2B5", "EIF6", "ELMOD2", "EMC2", "EMC7", "EMD", "EPDR1", "EPHA7", "EPHX1", "EPPK1", "ERAP1", "ERAP2", "ERBIN", "ERG28", "ERGIC1", "ERGIC3", "ERLIN1", "ERLIN2", "ERMP1", "ERO1A", "ESYT2", "ETFDH", "EXOC7", "EXOSC3", "F11R", "FADS2", "FAF2", "FAH", "FAM129B", "FAM162A", "FAM49B", "FANCD2", "FASN", "FBL", "FDFT1", "FDPS", "FDXR", "FECH", "FERMT2", "FGFR1OP", "FIS1", "FKBP10", "FKBP14", "FKBP2", "FKBP7", "FLOT1", 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sha256:19362be22ca1e3bb49678e701a85519ee0c6280b7bac4e55434846e1c382303b +size 146102 diff --git a/msigdb_gocc/consensus.joblib b/msigdb_gocc/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..6598ae4e7ad3ece68a43ca7cfa711af780e72f04 --- /dev/null +++ b/msigdb_gocc/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:e008cdeca367c54168151db8c5f3fe30fc7974dc0d05052ae2a58d9d13cbbd4a +size 148040 diff --git a/msigdb_gocc/df_merge.tsv b/msigdb_gocc/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..7d7aa97ea30a26235102997725d13567b7e9bb37 --- /dev/null +++ b/msigdb_gocc/df_merge.tsv @@ -0,0 +1,73 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Inner mitochondrial membrane protein complex 43 76 4.607303327989243 4.079247255539542e-06 27.97087378640777 75.4635922330097 1.520604987560478 0.2664687480104057 12.043574857699111 6.447783897817093 2.3558486082891616 0.3692317407906862 1.4882926081766948e-17 1.841177093347847e-07 4.223465404264662e-09 4.347633275019364e-11 8.508257823822515e-20 +Intrinsic component of organelle membrane 101 142 4.578797111592223 4.6765753478617e-06 52.51699029126213 129.34223300970874 2.0732064315361294 0.2796588394070637 24.692225942786415 15.820346456508432 2.8130846896968285 0.39829365000917 1.7043909165486728e-32 0.0030261455975404 9.888873527780206e-07 1.1782464088380508e-22 2.5487426481799787e-37 +Intrinsic component of mitochondrial membrane 40 53 4.536926941674139 5.707986913572327e-06 20.225728155339805 46.883495145631066 1.6360090381123027 0.2606204408334349 9.735582728924424 5.567853242112672 2.0682718238883013 0.3438986948818692 1.0684338097578883e-20 0.0063852408669871 0.0001066840361729 3.8612241234901926e-12 2.354651365736154e-24 +Intrinsic component of endoplasmic reticulum membrane 39 56 4.527068895808534 5.9807445751403066e-06 21.439320388349515 53.03155339805825 1.5445183869163015 0.2945609219212759 9.936629672422429 6.151523176643304 2.1054078800196185 0.3580268322643601 3.449871126955112e-11 0.4570575797650001 0.033005107755267 8.119733842698614e-09 2.8220156140103232e-14 +Outer membrane 51 96 4.180274864167292 2.911569477848097e-05 28.936893203883496 87.79611650485437 1.4859238244628277 0.3236686433663402 11.632349354832256 8.24751710010496 1.9336855473946637 0.38878066573106 1.2541742827269856e-21 0.0002137267005037 1.1938841481928453e-06 3.3439290984775367e-17 7.666830622414e-25 +Intrinsic component of mitochondrial inner membrane 25 35 3.7157575534676095 0.0002025957772848 13.946601941747574 31.446601941747577 1.7062420859184484 0.2149692261988765 6.992163651608136 3.3601842163433866 1.8185871159494191 0.3070405082296492 9.631940592260192e-17 0.0017444833819259 0.0001113664394611 2.099487500858404e-08 3.0701133345835803e-15 +Lysosomal lumen 23 35 3.5846714594222666 0.0003375027853296 18.075242718446603 34.54368932038835 0.7848519845050315 0.1014568164283454 6.206531846566726 3.2976210873168883 3.038689298289951 0.2012423645269794 1.4665101459551097e-12 0.0003058609788467 3.666242717515935e-06 6.053774818756919e-10 3.929979563385349e-13 +Outer mitochondrial membrane protein complex 13 17 3.4398457928831503 0.0005820457190615 7.157766990291262 15.730582524271844 1.3245491566248977 0.2112996285983387 3.5767402396348245 0.8689557679680192 1.477430451036954 0.2853006280851536 5.6644287937329686e-11 0.0001122733832082 0.0008717411361388 2.591400071592553e-07 4.049640390482079e-13 +Golgi cisterna 16 27 3.380052522955828 0.0007247197904254 8.524271844660195 22.490291262135923 0.9086972174309816 0.318868202549777 4.2525712614684625 5.269200019661922 1.391079392561209 0.3149122340418913 0.000726389293685 0.297366720714231 0.1554832015057707 0.0082077294132096 0.0001840815286022 +Intrinsic component of plasma membrane 45 82 3.373709101060882 0.0007416269590907 29.711165048543688 79.49271844660194 0.9914207279546418 0.2992612012372248 13.467745416506318 12.62980929789956 2.1277799030157807 0.3627370007757806 0.0435110016545176 0.6637318598957465 0.292553138399099 0.033611002490351 0.1441471050256135 +Vacuolar lumen 26 60 3.3553544775383077 0.000792633465922 22.262135922330096 63.33980582524272 0.6562244405592584 0.1887666227175413 6.920437110961116 4.902057024259538 2.8947011026985514 0.298290072492813 6.4267748116099485e-09 0.002200987019757 0.0001147648467817 6.375257885270477e-07 5.113996218804716e-09 +Respirasome 23 45 3.3311757573318905 0.0008647998186961 15.08495145631068 43.37378640776699 1.2524823540042158 0.2922262294299136 6.290312072426717 4.489587979561489 1.7783434517583476 0.3462844006183536 4.467750871765904e-08 5.111567422339664e-05 1.0872801784506749e-07 8.225702041634887e-07 2.674658035174025e-09 +Golgi membrane 65 141 3.2972196072609496 0.0009764711877211 41.28398058252427 131.19174757281553 1.6327747521284677 0.3511039607499193 15.277988344159814 17.44963987873233 1.926180921267262 0.4033858283713009 3.448066647587042e-09 0.0522091470058362 0.0007414158430589 1.2458087123830629e-06 5.220555464466581e-11 +Endoplasmic reticulum golgi intermediate compartment membrane 18 24 3.2256304930887487 0.0012569552071541 10.49271844660194 25.839805825242717 1.5441023898993702 0.2324243418613106 5.505729177420246 3.7718384126099376 1.49831312620529 0.2965572765953523 6.5891341327469e-05 0.0285808600856777 0.0157478410048603 0.0003302169514715 9.73767408137118e-06 +Azurophil granule membrane 9 21 3.2249288338620223 0.0012600398696218 7.856796116504855 21.259708737864077 1.0757479237162697 0.2373572682944545 3.393508570011604 2.63895903142419 1.639408148995933 0.2881313440808664 1.2766455771294384e-05 0.0204708743585679 0.0720571885403784 1.2098982240396002e-05 5.575737006440399e-05 +Intrinsic component of mitochondrial outer membrane 10 15 3.1758788504449043 0.0014938332276208 5.004854368932039 12.186893203883496 0.537559322132711 0.4142348023165385 2.5976045215999015 2.144426747635188 1.2224430201503769 0.3320793466689031 2.524624250032533e-05 1.0 0.1993869387044997 1.3272125229579008e-05 2.5169228203865123e-09 +Golgi cisterna membrane 10 19 3.171502159094472 0.001516527407458 6.233009708737864 17.101941747572816 0.7930989258143627 0.3092897028410761 3.2184356191878685 3.952300069740005 1.3504727992091758 0.2953094162507478 0.0002259538298281 0.2220822570468345 0.3955810682553247 0.0081044088621321 0.0001665225081846 +Endoplasmic reticulum protein containing complex 29 60 3.1655084246576397 0.0015481217865478 20.067961165048544 61.213592233009706 0.544324442160867 0.4875881372361492 7.672624563199495 5.300944201362535 1.5348103009085623 0.3893079894443684 7.367920986844244e-06 1.0 0.6495768562618007 0.0045318552746038 9.08641907793181e-07 +Cytochrome complex 7 17 3.0427660688952702 0.0023441448431311 6.021844660194175 16.08495145631068 1.0267019648816196 0.2321293206617183 2.9315837025395948 1.6175814223208935 1.624269406530766 0.2919563386676546 1.4726801524297762e-05 0.000349084453734 0.0001585002786519 5.5308739194744206e-05 5.065093383128868e-05 +Microbody membrane 19 29 3.0241665805961087 0.0024931911800116 9.83980582524272 26.8373786407767 1.0322166739723002 0.3740701224912098 5.101262737371427 4.075770333088885 1.3138416014090577 0.3534887732287703 0.0004612005893323 1.0 0.4242240140575919 0.0118522943314895 0.0015622461376846 +Secretory granule membrane 26 67 3.0067810494503573 0.0026402985899096 19.699029126213592 69.8495145631068 0.9295860214656708 0.3887665887416008 7.284889203542463 7.49087955205396 1.5950364553562375 0.3903287060113383 4.909654227127803e-05 0.0559390979061329 0.2522992371519743 0.0001208483788538 6.363963400527423e-05 +Azurophil granule 23 63 2.9894637260199453 0.0027946762863704 20.46359223300971 67.00485436893204 0.4795255752980384 0.3097891700346699 6.177875864944045 5.290582926033595 2.1760997104513735 0.3628132485163926 1.804417004489893e-07 0.0176779282664691 0.0987427785556486 0.0004506920536562 5.687860207994201e-07 +Late endosome 21 69 2.9864086552140576 0.002822751537322 15.655339805825244 65.18203883495146 0.1482522199608934 0.3683478922291265 6.675389202214119 9.543379127098556 1.7080817701484334 0.368772234437858 0.0007315292867109 0.6312378177493598 0.1347944849764237 0.0004400111129202 0.0003911491692499 +Exocytic vesicle 18 40 2.906754677136994 0.0036519948223523 12.106796116504857 38.40533980582524 0.7408080162244459 0.4227017753873355 4.952517495270036 4.6543925000719675 1.3317240485888555 0.365166844745196 0.0013196380383265 0.4829170776296618 0.1426674419185315 0.0171137548039357 0.0024374463939659 +Transporter complex 30 56 2.8926965386202763 0.0038195013148909 16.033980582524272 55.199029126213595 0.256193630237002 0.358562058071074 7.704418772430675 7.665912382074106 1.666161547187811 0.3440522205931707 2.360348086373092e-06 0.000686752050236 0.0005411829706675 0.0008981179696018 6.589772688418549e-07 +Lipid droplet 9 31 2.881901879495924 0.0039528280367235 7.313106796116505 30.72087378640777 0.9597061621709796 0.3916106255858687 3.663189105886808 2.181620314734523 1.1934081113966928 0.3497541884861006 0.0003181730958658 0.0399341953324298 0.0036673828223822 0.0010122977413289 0.0012083889035143 +Golgi stack 18 36 2.876960331903515 0.0040152606731571 9.67233009708738 31.25242718446602 0.7055900861920908 0.4265468940333196 4.557817503574521 5.847941213698429 1.2226912303929196 0.3463938041520717 0.0021373182211583 0.377722993581858 0.2426635790855314 0.031009617990344 0.0002563222355264 +Mib complex 7 11 2.841160652937982 0.0044949662124242 4.669902912621359 10.016990291262136 0.8674199579421746 0.3102009046029466 2.3929035436504367 0.6011337749949848 1.2568635951567688 0.31203902687269 7.874802017413471e-09 0.0607401038440192 0.1180585699575878 0.0001991597833083 3.028938715404879e-08 +Endoplasmic reticulum golgi intermediate compartment 24 49 2.7635485073331183 0.0057176593120258 14.888349514563108 49.49271844660194 1.4759277407874345 0.3201471070907981 6.47003250199477 5.053350843348441 1.420924643396655 0.3585240832471577 4.153350823386576e-05 0.0115248505448644 0.0024838215389039 0.0005811578342293 4.159534705346476e-06 +Synaptic vesicle membrane 5 15 2.7529817816075126 0.0059055182490848 5.099514563106796 14.07766990291262 0.7734258277348643 0.4227625879426745 2.579286376297321 2.2325453295101236 1.0485572818049853 0.3297289695807819 0.2386444686616772 1.0 0.1163398228410075 0.1820516573570916 0.3438081646501767 +Intrinsic component of golgi membrane 10 12 2.7477696745089157 0.0060002142946329 4.655339805825243 10.08495145631068 1.3178763872097854 0.2129685736028588 2.6046347098798024 1.9780511021437377 1.2704958978874823 0.2699640456705705 0.0002538748383503 0.0172375696548913 0.0075361578498098 0.0004698927732866 0.000798592209508 +Phagocytic vesicle membrane 13 25 2.713598834202291 0.0066556711122052 7.512135922330097 23.83009708737864 0.5348434256443761 0.4468744105904624 3.681144332021715 3.0024693704800938 1.1652764437248655 0.3385441964418395 0.1032884224164973 1.0 1.0 0.0593060830293246 0.008913025090531 +Snare complex 9 14 2.689851015435976 0.0071483924816713 6.20873786407767 15.79368932038835 0.8138466711937282 0.3737991711938105 3.1112263618988054 3.010283181947674 1.1802712183474584 0.3261149602927671 0.0299964490106926 0.187449079081247 0.0080456420559546 0.0846608217542885 0.0558327828623465 +Organelle inner membrane 106 244 2.6639620617508366 0.0077226271689316 79.6747572815534 237.5995145631068 1.5941979045672914 0.3906136455525962 32.81710191865129 21.467005610038825 2.570753705211445 0.4244355950981394 1.4397268791351878e-35 1.3055715209293076e-08 4.8858215753962013e-14 7.155256134256937e-19 1.7665662088529005e-37 +Nuclear inner membrane 8 18 2.587386027257174 0.0096707182434163 7.347087378640777 20.57281553398058 1.3204335588742686 0.2519451141048848 3.6006224195129035 1.9968516080603145 1.2188770932171689 0.2896682474252494 0.0002538748383503 1.0 0.0614247268920475 0.0180565405233996 0.0001478156049624 +Membrane microdomain 22 64 2.5862744834024576 0.0097019635364989 14.75485436893204 63.49029126213592 0.5762129399877682 0.5023556315347317 6.545256989336744 6.436953608643344 1.167657055169838 0.3823949317010994 0.1006463474826871 0.2390350583825033 0.1165444039160723 0.1888024401065534 0.0895267709622813 +Proton transporting two sector atpase complex 9 22 2.566543898343643 0.0102717622626267 7.116504854368932 22.25728155339806 1.0735578367707936 0.2848832687688338 3.2910616544032156 1.9833825153714253 1.32099194967518 0.2987458873835026 6.191534775953672e-06 0.151306852499084 0.0420348553288257 0.0012324742743759 3.03436196363312e-06 +Transport vesicle 32 94 2.5199009819531173 0.0117387851242234 26.046116504854368 92.34708737864078 0.9512017428916244 0.4458616213657612 9.46815354334768 9.09007867686459 1.424803887648301 0.3967491654773343 0.0010390807416524 0.3582794844835456 0.106384805735638 0.0106720494125794 0.0019609522776629 +Endoplasmic reticulum lumen 27 58 2.515792159466387 0.0118765197033383 18.07766990291262 59.737864077669904 0.9896277047863468 0.3946249358858228 7.513340007333169 6.273245958458151 1.4320597420402308 0.3846324865730224 0.009413839255134 0.559981185156499 0.2216305912196411 0.22400409765679 0.0014076689813867 +Vacuolar membrane 38 126 2.5078862112889317 0.0121455772048306 31.91504854368932 121.20631067961163 0.8693310080509177 0.3422944242486927 10.598363436017626 13.850227259030053 1.9844114292962869 0.3837860427998523 3.4180649179223726e-09 0.4851629446799355 0.1054438813849287 5.55316351242778e-07 1.2747323096867673e-07 +Nuclear outer membrane endoplasmic reticulum membrane network 166 317 2.500159690446796 0.0124137335646272 98.3519417475728 305.0218446601942 1.8626549185660248 0.4346737740195964 40.114822105305365 33.029069404441934 2.648813561163414 0.4525721946789457 4.475172481784152e-32 0.0001785297718435 5.101292532412604e-07 1.6752616164913602e-22 1.2874861900939436e-39 +Oxidoreductase complex 20 62 2.4712400670370447 0.0134645396082611 16.138349514563107 58.1747572815534 0.4112275970760134 0.4385210691837483 8.292749505639035 5.03902669070441 1.4297411393453454 0.366860872580609 0.000252590660866 0.0001220973370819 5.353855778852642e-05 0.0031928161135449 7.290650337771797e-06 +Cis golgi network 8 18 2.4668700143617333 0.0136299825954862 5.446601941747573 14.91747572815534 1.304763677188147 0.2415633778835601 2.9087352716231463 3.2280604409731746 1.23405443481851 0.2890539664507128 0.02047141811426 0.1715759324473242 0.0538434207197609 0.0671599559498881 0.0024204837857025 +Endoplasmic reticulum tubular network 5 11 2.4652902000635755 0.0136902322124259 4.456310679611651 11.402912621359222 0.7597390036291544 0.4204688348420043 2.5600618129260964 1.9933849978482647 1.110800197793671 0.3406591463359876 0.0016518039309861 0.1006582454154426 0.191600110602388 0.0152248647419399 0.0034992238505004 +Proton transporting two sector atpase complex proton transporting domain 5 10 2.4565029218077115 0.014029666127413 4.053398058252427 10.283980582524272 1.020958321179617 0.2307004649223604 1.8491832641634656 1.1862626633334956 1.3576055733210162 0.273185751006507 1.649856676648641e-05 0.0697581245313758 0.0088504827764808 0.000366006536683 4.367834065541858e-05 +Specific granule membrane 4 13 2.414657518516144 0.0157500111711346 4.703883495145631 15.434466019417476 0.8701513897757543 0.3699585460258285 2.477017558764293 2.6655071934549124 0.9998631482292508 0.308737972868479 0.0488174926546911 0.0230489069918226 0.0803922289273931 0.0300192966842153 0.0877145718471434 +Copii coated er to golgi transport vesicle 13 30 2.399443883852316 0.0164199963971738 10.810679611650484 32.4247572815534 0.9209697551014924 0.3949407296339237 5.01338814607213 3.9617918728777735 1.2509556054930144 0.3456813773327062 0.0191555946547616 0.2766173679843171 0.1355867800667393 0.2193268794643932 0.0153483993146073 +Respiratory chain complex iv 5 10 2.3847481142742404 0.0170908188170695 3.754854368932039 9.74271844660194 0.8119042784517004 0.2590637228606872 2.032646352020888 1.0643473720992946 1.3870085883810457 0.2875864020654643 0.0006151896190365 0.083126337411673 0.0126574737404708 0.0086586519898169 0.0013369974246366 +Micos complex 4 5 2.3502004771698144 0.0187633020964956 2.4927184466019416 4.725728155339806 0.7557668283408772 0.3464970141803932 1.2077602589329477 0.4877312285913208 1.1862461875397572 0.3249829583805667 5.650461951796286e-06 1.0 1.0 0.0007102815399137 1.3106068439724131e-05 +Intrinsic component of synaptic vesicle membrane 4 11 2.349375560605484 0.0188049286869123 3.648058252427184 9.116504854368932 0.724313202500786 0.4129003553732678 2.1933086936710184 1.7154408466980504 1.018214829869002 0.3297596143558817 0.0963402202365331 1.0 0.2297987482657219 0.1374615323876937 0.1410707299584872 +Dynactin complex 1 5 2.263035884662 0.0236334772950166 1.922330097087379 4.978155339805825 0.7536051706711276 0.4281847634474278 1.1982132360298303 0.5138929048129751 0.8369340042224647 0.3070790527939186 0.0496528042147836 1.0 0.0832836732680532 0.0186627473263165 0.0675218785318175 +Proton transporting atp synthase complex 4 10 2.2511720559261343 0.0243746420496429 4.157766990291262 11.08495145631068 0.5328143574617974 0.3012358599713604 2.3610641964760792 1.138499586439592 1.3748267965121657 0.2836171984539964 0.0042940863146269 0.0786913117950012 0.0113213926532688 0.0621585272883563 0.0010053263520343 +Mitochondrial envelope 134 321 2.2485339445989103 0.0245421631134767 98.51456310679612 309.05582524271847 1.3784407074331837 0.4315621435689855 37.853540978552445 29.592036616547553 2.6690149272426917 0.4358105924461398 8.127569182829033e-43 3.417292568110593e-11 3.012375200041382e-17 1.4878613743710855e-27 3.461322316741105e-47 +Organelle subcompartment 197 397 2.2251255584354936 0.0260728104147487 115.97815533980582 370.4077669902912 1.8466078375892352 0.461199583276842 45.24176702976874 43.040100266333 2.697642340677977 0.4541841641473397 7.943306999860641e-35 3.1589834948273246e-05 4.020982758203566e-09 3.845194566423177e-24 1.1701526181569536e-41 +Autophagosome membrane 5 14 2.2068434603650644 0.0273249975955904 4.174757281553398 13.37135922330097 -0.0098942360451326 0.445924723627937 2.326200220393679 3.0901432865083773 1.1383635180898088 0.3067757682348186 0.0085357436861326 1.0 0.3467918934582977 0.0893115916137597 0.0187017730028202 +Golgi apparatus subcompartment 36 105 2.196149340904624 0.0280812559542515 23.898058252427184 88.56796116504854 0.6438651907142603 0.5157075238910589 9.044082768463602 13.85685287398648 1.2182273227220288 0.3801323692583779 0.0008101910349587 0.1430583240174933 0.0159626383712572 0.0025406668575644 0.0007736371687771 +Hrd1p ubiquitin ligase erad l complex 3 5 2.1956560306939115 0.0281165725359509 1.5922330097087378 3.79126213592233 0.7277489081729471 0.3220832800800837 1.0445131090737272 0.9111612984907131 1.2162191074948896 0.2849748010669527 0.0021018851435908 1.0 1.0 0.0112385866308786 0.0001708540892308 +Er ubiquitin ligase complex 3 5 2.1956560306939115 0.0281165725359509 2.0970873786407767 4.70873786407767 0.8764155338390741 0.2924583478733635 1.3110031963021629 1.3573322490080977 1.246637632205364 0.2924172085124771 0.0065740916466848 1.0 1.0 0.0229613270793894 0.0009118158302113 +Nadh dehydrogenase complex 10 24 2.1501577959027443 0.0315427352302339 7.419902912621359 23.609223300970875 0.690247022635013 0.3818090321561181 3.6908298840900926 3.1049932192976284 1.21822710313397 0.3228613418826432 0.0004164478787279 0.0196403757049561 0.0008840144918394 0.0043649502990921 4.558635539447923e-05 +Organelle membrane contact site 8 17 2.1485683706736 0.0316686312007659 6.817961165048544 16.400485436893202 0.815819301321945 0.3904411977369264 3.451940177462974 2.047328298639296 1.2919706717077657 0.3464717655445403 0.0131785756289622 1.0 1.0 0.2064377407436189 3.170481154810999e-05 +Endoplasmic reticulum 226 488 2.1373205577193146 0.0325719279084979 139.71116504854368 475.50728155339806 1.972579372344309 0.4597126503683645 50.29410175615224 47.94654634280014 2.8130551221954065 0.458598772128197 3.3587123107617765e-39 0.0003871242900498 1.6781114718033577e-07 2.8721250955887563e-24 5.1772716463307286e-46 +Respiratory chain complex iii 2 8 2.1314299141622306 0.0330537406317015 2.5145631067961167 7.186893203883495 0.8648567981956616 0.2640480169416735 1.5224155414895728 0.9433070612984726 1.3007640218760226 0.2795290338624424 0.0143018721877003 0.0017062060788896 0.0066572828402184 0.0379575415698398 0.0225979674873623 +Pore complex 5 8 2.1247379306407663 0.0336084865705232 3.2111650485436893 8.830097087378642 1.029129610796519 0.2182996080526768 1.893158762220583 0.772882004264421 1.343874754683687 0.2717215815078918 0.0042940863146269 0.0786913117950012 0.0005309775927247 0.0073447144383531 0.0010053263520343 +Golgi lumen 3 5 2.120838655050944 0.0339353825024133 1.745679012345679 4.548148148148148 1.1368717941323 0.2457507117503182 1.2159484823715767 1.4039724163790972 1.161880305109492 0.2643265801751675 0.1412206545018741 1.0 1.0 0.1800390494619342 0.0674365169251515 +Phagocytic vesicle 22 43 2.104468090146453 0.035337635296945 11.54126213592233 41.59708737864078 0.3919256884663005 0.5681630099638236 4.854259100699266 4.0100348958770144 0.9938295058309184 0.3509625084864278 0.1148297707640586 1.0 1.0 0.0337698983302116 0.02302497178709 +Mitochondrial protein containing complex 57 157 2.100013931563216 0.0357276156230643 45.62621359223301 153.59708737864077 0.8032126729603613 0.4024101172023991 21.080430630469312 12.423857071229754 2.191669513941161 0.4117346592056412 1.0809484563746556e-15 2.4268746710395653e-08 2.223087163357044e-09 1.5321742049740318e-11 8.158876614045968e-18 +Pigment granule 18 61 2.0988952420649065 0.0358261363776468 17.058252427184467 60.37135922330097 0.3452760243889364 0.5728855837677844 7.454164461546019 2.3255555964379067 1.200064167427868 0.3798846852248331 6.92383982959466e-05 1.0 1.0 0.0662267021572276 0.0001013550764048 +Lumenal side of membrane 6 10 2.098537359788154 0.035857703233542 3.686893203883495 9.509708737864075 0.6270696996832885 0.3351332813726532 1.8490414883089543 0.9791034697552432 1.2332692274886168 0.3003490996154719 0.0112321972683931 1.0 1.0 0.0152248647419399 0.0034992238505004 +Mitochondria associated endoplasmic reticulum membrane 6 10 2.05172549230082 0.0401963478418629 4.191747572815534 9.240291262135925 0.7019541594808174 0.4009163152547425 2.0831338076447135 1.0418560326821893 1.1194321867771957 0.3336055532093068 0.0053451996563463 1.0 1.0 0.3559534457378639 1.2147954097366526e-05 +Integral component of synaptic vesicle membrane 4 6 2.0364398466082485 0.0417062076540517 2.2475728155339807 4.910194174757281 0.8567274645780141 0.3149754325120096 1.3818760752746044 1.4445051429216968 1.1133243513780926 0.2989777184888048 0.0301377643441986 1.0 0.1515272625734178 0.0621585272883563 0.0465653262864464 +Microbody 24 57 2.006584663540471 0.0447939056600721 14.5873786407767 55.157766990291265 0.5308798958236631 0.4622505798174944 6.656600193656261 6.967459933597681 1.141402376279513 0.3502304815174672 0.0007510588787052 0.4243503559946278 0.2997470465879412 0.0062659657814626 0.001208142066949 +Atpase dependent transmembrane transport complex 3 5 1.971786303173552 0.0486340065802992 1.5970873786407769 3.4927184466019416 0.1179078987480682 0.4979466809882105 1.120329035464483 1.0275077720866923 1.0457547306378463 0.3180582408906721 0.0143018721877003 1.0 1.0 1.0 0.0225979674873623 diff --git a/msigdb_gocc/metrics.json b/msigdb_gocc/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..f570bbd73abbe47c704832fb422263e48231d07a --- /dev/null +++ b/msigdb_gocc/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3221, + "annotations_size": 902, + "title": "Average number of proteins per term", + "value": 29.431263858093125 +} \ No newline at end of file diff --git a/msigdb_gocc/paths.json b/msigdb_gocc/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..1d9157b00ccfa6e4def039b60bee8eafe1a1dc82 --- /dev/null +++ b/msigdb_gocc/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/msigdb_gocc/fragment/C201/C201_val_log2fc"} \ No newline at end of file diff --git a/msigdb_gocc/result.tsv b/msigdb_gocc/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..c972822fa1e9412225985fc5a3ba7cfa7335a842 --- /dev/null +++ b/msigdb_gocc/result.tsv @@ -0,0 +1,290 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Inner mitochondrial membrane protein complex 0.6851857145845552 4.607303327989243 4.079247255539542e-06 0.0036727275062667 0.0013486579016943 76 O14949,Q9P0J0,P06576,P20674,P56385,Q9NVH1,Q9UDW1,P22695,P03886,O43676,O95139,O60830,O14925,O14548,P14406,P24539,P08574,Q9Y512,Q96CU9,Q16891,Q13505,P00403,Q6UXV4,Q86Y39,Q9Y5J6,Q99623,P13073,Q96IX5,O95168,O95299,O96000,O75964,Q9Y6M9,Q9NX63,Q9BPX6,O75431,P21912,P12236,Q5XKP0,Q9BUR5,Q53H12,P51970,P35232 43 +Intrinsic component of organelle membrane 0.7502587481382856 4.578797111592223 4.6765753478617e-06 0.004209396377523 0.0013486579016943 142 Q86Y82,Q9NVH1,Q8N6G5,Q86XL3,Q9NQC3,P20020,Q9Y2R0,Q5T9L3,Q9UM00,Q6ZRP7,O60830,O95070,Q9NRK6,P04439,Q13505,Q6P4A7,O95470,P57105,O15118,O75844,Q9Y282,Q16134,O60499,Q8N8Q8,Q8NBI6,Q99442,Q15070,Q8TCT9,O00767,Q5XKP0,Q9H9B4,Q86YN1,O43808,Q9BUR5,Q96S52,Q96A33,Q969X5,P13473,Q5H8A4,L0R6Q1,Q8NE86,Q9Y3D6,Q8N2H4,P56589,Q9GZP9,P42892,Q8TB61,Q9P035,Q9Y4P3,Q6UXV4,Q9NPA0,Q5SNT2,O76024,Q9H3K2,Q8TB36,Q8TCT8,Q969V5,Q9BWH2,Q15041,Q15125,Q14739,Q8IXI1,Q9UG56,Q8IWA4,P51572,Q53H12,Q9H9P8,P57088,O43819,Q9NZ01,O14925,P98194,Q9Y512,Q16891,Q12981,P27824,Q9NX63,O75298,O75431,Q9NP58,Q7L0J3,O75880,P12235,O15258,Q6NTF9,Q96AQ8,Q9HC21,Q9UH99,Q15006,Q92643,Q03519,Q9BUN8,P50416,O96008,Q9UBM7,Q15388,Q03518,P10321,Q9BPX6,Q16799,O95140 101 +Intrinsic component of mitochondrial membrane 0.7634050969712421 4.536926941674139 5.707986913572327e-06 0.0051353874695305 0.0013486579016943 53 Q9HC21,Q9H9P8,Q8NE86,Q9NVH1,O43819,Q9Y2R0,O60830,O14925,Q9NRK6,Q9Y512,Q16891,Q13505,Q6UXV4,P50416,O96008,Q6P4A7,P57105,Q16134,Q8N8Q8,Q8TB36,Q15388,Q9H3K2,Q15070,Q969V5,Q9BWH2,Q9NX63,Q9BPX6,O75431,Q8IXI1,Q9UG56,Q8IWA4,Q5XKP0,Q9H9B4,O95140,Q9NP58,Q9BUR5,O75880,Q53H12,P12235,Q96AQ8 40 +Intrinsic component of endoplasmic reticulum membrane 0.7386313399753296 4.527068895808534 5.9807445751403066e-06 0.005380122757476 0.0013486579016943 56 P57088,Q86XL3,Q9NQC3,Q15006,Q9UM00,Q9NZ01,Q9GZP9,Q92643,Q03519,Q9BUN8,P04439,Q8TB61,Q9P035,Q9Y4P3,Q9NPA0,O95470,Q12981,Q9UBM7,O76024,O75844,Q9Y282,Q8NBI6,Q99442,Q03518,P10321,P27824,Q8TCT8,Q8TCT9,O75298,Q15041,Q15125,O00767,Q16799,Q86YN1,P51572,Q96S52,Q96A33,Q5H8A4,Q6NTF9 39 +Outer membrane 0.6599092222909192 4.180274864167292 2.911569477848097e-05 0.0259208726117092 0.0052524713380381 96 O60313,P52789,Q8N4H5,Q9NVH1,P30536,Q9NS69,Q8NAN2,Q07820,Q9UKU0,Q9Y6C9,O43169,Q96RL7,P09601,Q8N2A8,P50402,Q9Y512,P45880,Q13505,Q16891,O75323,Q6UXV4,P21796,Q86UT6,Q9NUQ2,P50416,O96008,P57105,Q9UBM7,Q99623,Q8TB36,Q15388,Q9Y277,Q9Y371,Q969V5,Q9BWH2,Q9NX63,Q99720,O75431,Q8IXI1,Q8WWV3,Q8IWA4,Q5XKP0,Q9NX47,O95140,O00165,Q9HCL2,Q9NZJ7,Q9BUR5,Q9NP58,Q53H12,O00264 51 +Intrinsic component of mitochondrial inner membrane 0.7516640636136257 3.7157575534676104 0.0002025957772848 0.1670318767284779 0.030456898518493 35 Q9HC21,Q9H9P8,Q9NVH1,Q9Y2R0,O43819,O60830,O14925,Q9Y512,Q16891,Q13505,Q6UXV4,Q6P4A7,Q16134,Q8N8Q8,Q9H3K2,Q15070,Q9NX63,O75431,Q9UG56,Q5XKP0,Q9H9B4,Q9BUR5,O75880,Q53H12,Q96AQ8 25 +Lysosomal lumen 0.7318964445746104 3.5846714594222666 0.0003375027853296 0.2624924079350916 0.0338252791519246 35 P11117,P38435,O43681,P54802,O14773,P06865,P10619,P16278,P50897,P07602,P17900,Q8NHP8,P06280,Q9UM22,Q13510,O00584,P61916,P04062,Q14108,Q9NZJ7,P10253,Q8IV08,P13473 23 +Outer mitochondrial membrane protein complex 0.8260404259991265 3.4398457928831503 0.0005820457190615 0.4085381451184545 0.0525005238593481 17 Q8IWA4,Q5XKP0,Q8N4H5,Q15388,Q9Y512,Q13505,Q16891,Q9BUR5,Q6UXV4,Q9NS69,O96008,O75431,Q9NX63 13 +Golgi cisterna 0.7290319565093732 3.380052522955828 0.0007247197904254 0.4800040412846073 0.0549965681739772 27 Q16706,P98194,P0CG08,Q15363,Q8N6G5,Q8NBN3,P04439,P51572,Q96L58,O00461,Q8TBA6,Q08378,Q9BZG1,Q10472,Q10713,O95249 16 +Intrinsic component of plasma membrane 0.5580930273251785 3.373709101060882 0.0007416269590907 0.4878796866660068 0.0549965681739772 82 O15498,O00400,Q9Y289,Q8NHP6,P05141,P78310,Q92542,Q8NAN2,P20020,Q99797,P55011,P05023,Q8TDW0,O43657,O60637,P16615,Q8WTV0,Q9UIQ6,P04439,P23634,Q9UNK0,P05067,P27105,Q86UP2,P35670,O15118,P11279,P10321,Q15043,P30825,P27824,O96005,Q15375,Q8N2K0,P54709,P51790,Q9UJS0,Q13641,Q9BTU6,P51572,O00264,P12235,Q08722,P35613,P35232 45 +Vacuolar lumen 0.5693579487250882 3.3553544775383073 0.000792633465922 0.5109247348365329 0.0549965681739772 60 P11117,P38435,O43681,P54802,O14773,P06865,P10619,O00754,P50897,P07602,P16278,P17900,Q8NHP8,P06280,Q9UM22,Q13510,Q9H7Z7,O00584,P61916,P04062,Q14108,Q9NZJ7,P10253,Q8IV08,P13473,Q9BTY2 26 +Respirasome 0.6512448594725325 3.3311757573318905 0.0008647998186961 0.5417713228360727 0.0557178168902798 45 O14949,Q9P0J0,P20674,Q7KZN9,Q9UDW1,P22695,P03886,O43676,O95139,O14548,P14406,P08574,Q96CU9,P00403,Q86Y39,Q13423,P13073,O95168,O95299,O96000,Q9Y6M9,P21912,P51970 23 +Golgi membrane 0.6102981725526169 3.2972196072609496 0.0009764711877211 0.5857175610827505 0.0587184674216319 141 Q86Y82,L0R6Q1,O15498,O00400,Q15363,Q15392,Q8N6G5,Q8NBN3,Q99640,Q9Y296,Q9P2W9,Q7LGA3,Q8N2H4,Q10713,Q5T9L3,Q9UM00,Q6ZRP7,P61026,O95070,O95197,P98194,Q8N4A0,P24390,P04439,Q8IZA0,Q8TB61,Q96L58,Q8TBA6,Q9H7Z7,Q14789,O95249,O94923,P35670,Q15382,Q9Y282,Q16739,P0CG08,P52292,O60499,Q9Y371,P10321,Q08378,Q9Y3E0,Q7Z3C6,Q9NTJ5,Q14108,P51790,Q16706,Q9BVK6,Q16799,P49755,Q8NCH0,P51572,Q9NP58,Q9BUR5,O00461,Q92896,Q8IV08,Q8TBQ9,Q10472,Q96S66,O15258,P35613,Q6NTF9,Q8NF37 65 +Endoplasmic reticulum golgi intermediate compartment membrane 0.7129857079020187 3.2256304930887487 0.0012569552071541 0.6784128650770151 0.0668562330822896 24 O95070,Q03519,O15498,P53634,Q15363,Q9Y282,Q9BVK6,P24390,P61019,Q8N511,P49755,P51572,Q03518,O75396,Q15904,Q969X5,Q10472,Q9Y3B3 18 +Azurophil granule membrane 0.7402374588974346 3.2249288338620223 0.0012600398696218 0.6793075187559845 0.0668562330822896 21 P07602,P11279,Q07065,Q92542,Q9NZJ7,P27105,P13473,Q9NQX7,Q8NF37 9 +Intrinsic component of mitochondrial outer membrane 0.7997428011434016 3.1758788504449043 0.0014938332276208 0.7403563067025967 0.0698202925733076 15 Q8IXI1,Q8IWA4,Q8TB36,Q15388,Q9NP58,Q969V5,P50416,O96008,Q9BWH2,P57105 10 +Golgi cisterna membrane 0.754969153555118 3.171502159094472 0.001516527407458 0.7456250720834111 0.0698202925733076 19 P98194,P0CG08,Q15363,Q8N6G5,Q8NBN3,P51572,O00461,Q08378,Q10472,Q10713 10 +Endoplasmic reticulum protein containing complex 0.5488246022713363 3.1655084246576393 0.0015481217865478 0.7527827740354011 0.0698202925733076 60 O43681,Q15006,O15269,Q15005,Q9UBV2,Q9GZP9,Q92643,Q03519,Q9BUN8,Q9UGP8,P04439,P13674,Q9NPA0,P04843,Q96CS3,P67812,Q8IXB1,Q03518,Q53GQ0,Q8TCT9,P51571,Q15041,Q9H490,P07237,Q96S52,Q04323,Q9Y5M8,P46977,Q6NTF9 29 +Cytochrome complex 0.7547375405791731 3.0427660688952702 0.0023441448431311 0.8795957900109701 0.0881007770210131 17 O14949,P14406,O14548,P13073,Q7KZN9,Q9UDW1,P22695 7 +Microbody membrane 0.6691784910486285 3.0241665805961087 0.0024931911800116 0.8947762800997073 0.0899543377748213 29 Q8NBU5,Q9Y3D6,P56589,Q9UKU0,P40855,Q5T8D3,P28288,Q9BY49,P39210,P51648,P33121,Q9NR77,Q8TB36,Q6IAN0,O43808,O00116,P04035,O15228,O75381 19 +Secretory granule membrane 0.5036404943363214 3.0067810494503573 0.0026402985899096 0.907883285841914 0.0909329245237312 67 Q15363,Q07065,Q92542,O75787,Q4KMQ2,P61026,P07602,P30519,Q5T9A4,P27105,Q9NQX7,Q969Q5,Q96JJ7,P84095,P11279,P10321,P42785,Q93050,P49755,Q9NZJ7,P10253,O00264,P13473,Q08722,P35613,Q8NF37 26 +Azurophil granule 0.5120677681044049 2.9894637260199453 0.0027946762863704 0.9198877893506224 0.0909329245237312 63 O43681,Q07065,Q92542,P06865,P10619,O00754,P16278,P07602,P17900,P06280,Q9H7Z7,P27105,Q9NQX7,Q96CS3,P11279,O15400,O00584,P61916,Q9NZJ7,P10253,P13473,Q9BTY2,Q8NF37 23 +Late endosome 0.5040737818125052 2.9864086552140576 0.002822751537322 0.9218966397571358 0.0909329245237312 69 Q8IY95,Q9GZP9,Q96PU5,P10644,P07602,Q9BUN8,P35670,O15118,Q04656,P11279,O15400,Q96A57,Q15043,Q8TCT8,Q7Z3C6,Q14108,P51790,Q9NP58,Q9NZJ7,Q8IV08,P13473 21 +Exocytic vesicle 0.6168179831239097 2.906754677136994 0.0036519948223523 0.9631215913776988 0.1097504583996291 40 Q86Y82,Q9BVK6,P50897,P11279,O43760,O60499,O15400,Q96A57,Q92542,Q9Y296,O14656,Q7L0J3,P05067,P20020,Q9BT78,Q92905,P51790,O76024 18 +Transporter complex 0.5422214042639036 2.8926965386202763 0.0038195013148909 0.9683110247304156 0.1097504583996291 56 O14949,Q9P0J0,Q9C0H2,Q9UDW1,Q4KMQ2,P05023,P22695,P03886,Q8TDW0,O43676,O95139,Q9Y5J9,P08574,Q96CU9,Q86Y39,P51798,Q9Y5J6,O95168,O95299,O96000,Q9Y6M9,Q9BPX6,Q8N2K0,P54709,Q9NUT2,Q9NP58,P51970,Q96S66,O75306,O75381 30 +Lipid droplet 0.642955256490101 2.8819018794959237 0.0039528280367235 0.9719149064304856 0.1097504583996291 31 Q01105,O43760,P51572,Q07065,Q8NBX0,Q9H6V9,Q99720,Q96RL7,Q8NF37 9 +Golgi stack 0.6269648650609202 2.876960331903515 0.0040152606731571 0.9734587675919 0.1097504583996291 36 Q16706,P98194,P0CG08,Q15363,Q8N6G5,Q8NBN3,P04439,P51572,Q9Y296,Q96L58,O00461,Q8TBA6,Q08378,Q9BZG1,Q14789,Q10713,O95249,Q10472 18 +Mib complex 0.8172739603503639 2.841160652937982 0.0044949662124242 0.9828129528525524 0.1181810352765204 11 Q5XKP0,Q9Y512,Q13505,Q16891,Q9BUR5,Q6UXV4,Q9NX63 7 +Endoplasmic reticulum golgi intermediate compartment 0.5618580844947986 2.7635485073331183 0.0057176593120258 0.9943275211298436 0.1387741870194591 49 Q9Y6Y8,O15498,Q15363,P80303,Q9Y3B3,O95070,Q03519,P53634,P24390,Q14789,Q9Y282,P61019,Q03518,Q02818,Q9BVK6,Q8N511,P49755,P51572,Q15904,O75396,P07237,Q969X5,Q10472,O15258 24 +Synaptic vesicle membrane 0.7236065137287964 2.7529817816075126 0.0059055182490848 0.995216430964982 0.1387741870194591 15 Q86Y82,O43760,O60499,Q7L0J3,O76024 5 +Intrinsic component of golgi membrane 0.7798082970566824 2.7477696745089153 0.0060002142946329 0.9956103057366356 0.1387741870194591 12 O95070,L0R6Q1,Q9Y282,P98194,Q8N6G5,Q8TB61,Q969X5,Q8N2H4,O15258,Q6ZRP7 10 +Phagocytic vesicle membrane 0.6329777526079985 2.713598834202291 0.0066556711122052 0.9975787777721108 0.1500853835802277 25 P61026,Q03519,P11279,Q93050,P04439,O75396,Q03518,P10321,Q9BZG1,Q9Y487,P13473,Q04656,Q01968 13 +Snare complex 0.7316859947449166 2.6898510154359756 0.0071483924816713 0.9984523324986656 0.157264634596769 14 Q86Y82,O15498,O60499,O15400,O75396,Q9UNK0,Q9P2W9,O95249,Q12981 9 +Organelle inner membrane 0.617386442885187 2.6639620617508366 0.0077226271689316 0.9990815711935436 0.1619955745668925 244 O14949,Q9BSK2,Q9BQ95,Q69YU5,P20674,Q7Z7H8,Q9NVH1,P05141,Q9H061,Q9H2D1,Q9UDW1,Q9Y2R0,P03886,O43676,O60830,Q9NRK6,P14406,P24539,P08574,Q13505,Q99643,Q6P4A7,Q86Y39,Q13423,O95202,O75844,Q8N8Q8,Q70HW3,P13073,Q15070,O75964,Q9Y6M9,O75208,Q99720,Q5XKP0,Q9UBX3,Q9BUR5,P16260,Q7KZN9,P40939,Q567V2,P22830,O14548,Q9Y5J9,Q96CU9,Q6UXV4,Q9Y5J6,Q6KCM7,Q5SNT2,Q99623,Q9H3K2,Q9BQT8,Q14739,Q9UG56,Q9UJS0,Q53H12,Q9Y619,Q9P0J0,Q9NVI7,Q9H9P8,O43819,Q10713,P22695,O95674,O14925,Q6NUK1,P50402,Q9Y512,Q16891,P00403,P39210,Q9H2V7,P20700,O95168,Q9NX63,O75431,P23786,P12236,Q8NBN7,Q9NUT2,O75880,P53701,P12235,Q96AQ8,O60313,P06576,Q9HC21,Q9UH99,P56385,Q14728,O43615,P53007,Q9Y6C9,O95139,Q03252,Q5T9A4,O96008,O95831,Q96IX5,O95299,O96000,Q9BPX6,P21912,O75746,P51970,P35232 106 +Nuclear inner membrane 0.6679294918053934 2.587386027257174 0.0096707182434163 0.9998439666130812 0.1872990256052975 18 O75844,P20700,Q9UH99,P50402,Q14728,Q99720,Q14739,Q5SNT2 8 +Membrane microdomain 0.466821448871244 2.5862744834024576 0.0097019635364989 0.9998483445629786 0.1872990256052975 64 Q86Y82,P05141,P04899,P20020,O14773,P05023,Q12959,Q8WTV0,P10644,P50897,P09601,P23634,P05067,P21796,P27105,O15118,Q04656,Q9BTU6,O94905,O75955,P13473,P35613 22 +Proton transporting two sector atpase complex 0.6254509206200601 2.566543898343643 0.0102717622626267 0.9999097604311388 0.1890842767528428 22 P06576,Q8N511,Q93050,P56385,P24539,Q15904,O75787,Q9Y487,O75964 9 +Transport vesicle 0.4879213538082984 2.5199009819531173 0.0117387851242234 0.9999763233740772 0.2060119379309846 94 Q86Y82,Q9Y6Y8,O15498,Q15363,Q9NR31,Q92542,Q9Y296,P20020,Q92905,P61026,P50897,P24390,P04439,O14656,P05067,Q8TBA6,O95249,O43493,Q04656,O76024,P11279,O43760,O60499,O15400,Q96A57,P10321,P51790,Q9BVK6,P49755,Q7L0J3,O00461,Q9BT78 32 +Endoplasmic reticulum lumen 0.4918944402073836 2.515792159466387 0.0118765197033383 0.9999791205117764 0.2060119379309846 58 Q6P179,Q96HE7,O43681,Q07065,O43852,P53634,P13674,O14656,P05067,Q86UP2,O15460,O43493,O76024,Q5JRA6,Q8IXB1,Q9NZ08,Q02818,P27824,O00584,Q8TED1,Q14257,Q9NWM8,Q96AY3,P07237,Q9BTY2,Q9Y680,Q32P28 27 +Vacuolar membrane 0.5190256016998082 2.5078862112889313 0.0121455772048306 0.9999836679899736 0.2067039743161748 126 P11117,Q8IY95,O00203,Q07065,Q92542,P10619,Q96RL7,Q8WTV0,P07602,Q9UIQ6,P42892,P27105,Q9NQX7,Q9H2V7,P51798,O15118,P11279,Q9Y6I9,O15400,Q9Y371,Q15043,P04062,Q8TCT8,O75503,Q8NCG7,Q7Z3C6,Q14108,P51790,Q8N511,Q93050,Q9NZJ7,Q9NP58,P10253,Q8IV08,Q9Y487,O75955,P13473,Q8NF37 38 +Nuclear outer membrane endoplasmic reticulum membrane network 0.62772500797947 2.5001596904467953 0.0124137335646272 0.9999872153803752 0.2073553273202555 317 Q969V3,Q96PC5,Q07065,Q86XL3,Q9NQC3,Q9P2W9,Q15800,Q5T9L3,Q9UM00,Q8TDW0,O60725,Q12959,O95070,O95197,P61026,P09601,P24390,P04439,P30519,P43307,Q6PIU2,P51648,Q16850,O95470,P04843,Q96CS3,O75844,Q9Y282,P84095,Q4ZIN3,Q8NBI6,Q99442,Q8WXH0,Q8TCT9,P51571,Q99720,Q14108,Q8N2K0,O60858,Q8N5M9,O00767,P20073,Q8N511,Q70UQ0,Q9NX47,Q86YN1,O75396,Q9HD20,Q9BUR5,Q96S52,Q96A33,Q8IV08,Q969X5,O00264,Q8N5B7,Q5H8A4,Q9Y5M8,P46977,Q06136,O00400,Q15363,P38435,Q96HE7,Q15392,Q9BRR6,Q9BT22,Q8NHP6,Q96G23,Q7Z2K6,Q9UKU0,P07099,Q9H6H4,Q9UBV2,Q9GZP9,P16615,Q9Y3B3,O43852,O75477,Q8N2F6,Q9UGP8,Q9BZF3,Q8TB61,Q9P035,Q9Y4P3,P26885,Q9NPA0,Q9HCU5,O76024,P67812,Q96JJ7,Q8NHH9,Q14534,Q8TCT8,Q15041,Q15125,Q14739,P37268,P51572,Q5VV42,Q9H3N1,P04035,Q10472,Q96S66,P35613,Q8NF37,Q6P179,P57088,Q99640,Q96AA3,O15269,Q9NZ01,Q15005,Q96RL7,O95674,P50402,Q12981,Q9BVG9,P16435,Q5JRA6,Q9NZ08,Q9Y6I9,Q53GQ0,P27824,Q5BJF2,Q7Z3C6,O75298,O14681,Q99735,Q9BVK6,P49755,Q15904,Q9NP58,Q04323,Q6UX53,Q6NTF9,Q96N66,Q15006,O75787,Q92604,Q92643,Q9BU23,Q03519,Q9Y394,Q96KC8,Q9BUN8,Q9Y320,O14656,Q86UE4,Q9NRR5,Q9NUQ2,P48651,Q9UBM7,Q6NUQ4,Q15382,P52292,Q8TD16,Q03518,P10321,Q9NTJ5,Q96HY6,Q16799,Q96AG4,O94905,A1L0T0,O75915,Q2TAA5 166 +Oxidoreductase complex 0.4668228427131574 2.4712400670370447 0.0134645396082611 0.99999510609338 0.2092981263662405 62 O14949,Q9P0J0,Q9UDW1,P09622,P22695,P03886,O43169,O43676,O95139,P31350,P08574,Q96CU9,P13674,Q86Y39,O95168,O95299,O96000,Q9Y6M9,P21912,P51970 20 +Cis golgi network 0.6484873584282878 2.4668700143617333 0.0136299825954862 0.999995793159489 0.2092981263662405 18 Q16706,P98194,P49755,P24390,O00461,Q8TBA6,Q14789,O95249 8 +Endoplasmic reticulum tubular network 0.7438691847473023 2.4652902000635755 0.0136902322124259 0.9999960186773142 0.2092981263662405 11 Q8NHH9,Q00765,P50402,Q9NQC3,Q9H6H4 5 +Proton transporting two sector atpase complex proton transporting domain 0.7591628327337441 2.4565029218077115 0.014029666127413 0.9999970812904916 0.2109126474487766 10 Q93050,P56385,P24539,Q9Y487,O75964 5 +Specific granule membrane 0.7003176562480448 2.414657518516144 0.0157500111711346 0.9999993959296536 0.2197894219440884 13 P30519,Q07065,O00264,P27105 4 +Copii coated er to golgi transport vesicle 0.578227940361561 2.399443883852316 0.0164199963971738 0.9999996731555232 0.2197894219440884 30 Q9Y6Y8,O95070,Q9Y282,Q9BVK6,Q15363,P49755,P04439,Q9NR31,O75396,P10321,P05067,Q969X5,Q9Y3B3 13 +Respiratory chain complex iv 0.7451630901440048 2.3847481142742404 0.0170908188170695 0.9999998233639422 0.2197894219440884 10 P14406,O14548,P13073,P00403,P22695 5 +Micos complex 0.8945895522388049 2.3502004771698144 0.0187633020964956 0.9999999619852944 0.2197894219440884 5 Q6UXV4,Q16891,Q5XKP0,Q9BUR5 4 +Intrinsic component of synaptic vesicle membrane 0.721907813100215 2.349375560605484 0.0188049286869123 0.9999999634124837 0.2197894219440884 11 Q86Y82,O76024,Q7L0J3,O60499 4 +Dynactin complex 0.8738188482766209 2.2630358846619996 0.0236334772950166 0.9999999995726164 0.25377853000125 5 O75935 1 +Proton transporting atp synthase complex 0.7194223538390714 2.2511720559261343 0.0243746420496429 0.9999999997845542 0.2574073387018147 10 P56385,P06576,O75964,P24539 4 +Mitochondrial envelope 0.6063031437429999 2.2485339445989103 0.0245421631134767 0.9999999998154692 0.2574073387018147 321 O14949,Q9BSK2,Q9BQ95,Q69YU5,P20674,Q7Z7H8,Q8N4H5,Q9NVH1,Q9NVT9,Q9H061,Q9H2D1,Q9NS69,Q9UDW1,Q9Y2R0,P03886,O43169,O43676,O60830,P09601,P14406,P24539,P45880,Q13505,P21796,Q96A26,Q86Y39,Q13423,P57105,O95202,Q8N8Q8,Q70HW3,P13073,Q9Y277,Q9Y371,Q15070,O75964,Q9Y6M9,O75208,Q8WWV3,Q5XKP0,Q9NX47,O00165,Q9UBX3,Q9HCL2,Q9NZJ7,Q9BUR5,O00264,P16260,Q7KZN9,Q8NAN2,Q9UKU0,P40939,Q567V2,P22830,O14548,Q8N2A8,Q9Y5J9,Q96CU9,Q6UXV4,Q9Y5J6,Q6KCM7,Q99623,Q9H3K2,Q8TB36,Q9BQT8,Q969V5,Q9BWH2,Q8IXI1,Q9UG56,Q8IWA4,P52888,Q9UJS0,Q53H12,Q9Y619,Q9P0J0,Q9NVI7,Q9H9P8,P52789,Q07820,O43819,Q10713,P22695,Q96RL7,O95674,O14925,Q6NUK1,Q96H78,Q9Y512,Q16891,P00403,P39210,Q86UT6,Q9P0S9,Q9H2V7,Q12981,O95168,Q9NX63,O75431,P23786,P12236,Q8NBN7,Q9NUT2,Q9NP58,O75880,P53701,P12235,Q96AQ8,O60313,P06576,Q9HC21,P56385,P30536,O43615,P53007,Q9Y6C9,O95139,Q9Y320,O75323,Q9NUQ2,Q5T9A4,P50416,O96008,O95831,Q15388,Q96IX5,O95299,O00584,O96000,Q9BPX6,P21912,O95140,O75746,P51970,P35232 134 +Organelle subcompartment 0.611132129175204 2.2251255584354936 0.0260728104147487 0.9999999999552396 0.266959457130818 397 Q969V3,Q8N6G5,Q96PC5,Q07065,Q86XL3,Q9NQC3,Q9P2W9,Q15800,O15127,Q5T9L3,Q9UM00,Q8TDW0,O60725,Q12959,O95070,O95197,P61026,P09601,P24390,P04439,P30519,P43307,Q96ED9,Q6PIU2,Q96L58,Q8TBA6,P51648,O95249,Q16850,O95470,P04843,P35670,Q96CS3,O75844,O14578,Q9Y282,P84095,Q4ZIN3,O60499,Q8NBI6,Q99442,P04062,Q8WXH0,Q8TCT9,P51571,Q99720,Q14108,Q8N2K0,O60858,Q8N5M9,O00767,P20073,Q8N511,Q70UQ0,Q9NX47,Q86YN1,Q9BTU6,O75396,Q9HD20,Q9BUR5,O00461,Q96A33,Q96S52,Q8IV08,Q969X5,O00264,Q9NPR9,Q8N5B7,Q5H8A4,Q9Y5M8,P46977,Q06136,O14828,Q4J6C6,O00400,Q15363,P38435,Q96HE7,Q15392,Q9BRR6,Q9BT22,Q9NX62,Q8NHP6,Q8N2H4,Q96G23,Q7Z2K6,Q9UKU0,P07099,Q9H6H4,Q9UBV2,Q9GZP9,P16615,Q9Y3B3,O43852,O75477,Q8N2F6,Q9UGP8,Q9BZF3,Q8TB61,Q9P035,Q9Y4P3,P26885,Q9UNK0,Q9NPA0,Q9HCU5,O43493,O76024,P67812,Q96JJ7,Q8NHH9,Q96A57,Q14534,Q8TCT8,Q15041,Q15125,Q14739,P37268,P51572,Q5VV42,Q9H3N1,P04035,Q10472,Q96S66,P35613,Q8NF37,Q6P179,P57088,Q99640,Q96AA3,O15269,Q10713,Q9NZ01,Q15005,Q96RL7,O95674,P98194,P50402,P05067,Q12981,Q9BVG9,Q04656,P16435,Q5JRA6,P0CG08,Q9NZ08,Q9Y6I9,Q53GQ0,P27824,Q5BJF2,Q7Z3C6,O75298,O14681,Q99735,Q9BVK6,Q00765,P49755,Q15904,Q9NP58,Q04323,Q6UX53,Q6NTF9,Q8NBN3,Q9Y296,Q96N66,Q15006,O75787,Q92604,Q92643,Q9BU23,Q03519,Q9Y394,Q96KC8,Q9BUN8,Q9Y320,O14656,Q86UE4,Q9NRR5,Q9NUQ2,Q14789,P48651,Q9UBM7,Q6NUQ4,Q15382,P52292,Q03518,P10321,Q08378,Q9NTJ5,Q16706,Q96HY6,Q16799,Q96AG4,O94905,Q9BZG1,A1L0T0,O75915,Q2TAA5 197 +Autophagosome membrane 0.6474699446053914 2.2068434603650644 0.0273249975955904 0.9999999999859748 0.266959457130818 14 P11279,Q9Y6I9,Q9Y371,P13473,Q7Z3C6 5 +Golgi apparatus subcompartment 0.469491022645678 2.1961493409046233 0.0280812559542515 0.9999999999930462 0.266959457130818 105 Q15363,Q8N6G5,Q8NBN3,Q9NX62,Q9Y296,Q8N2H4,Q10713,O15127,Q5T9L3,P61026,P98194,P04439,Q96ED9,Q96L58,P05067,Q8TBA6,Q14789,O95249,O43493,P35670,Q04656,O14578,P0CG08,O60499,Q96A57,P04062,Q08378,Q7Z3C6,Q16706,Q9BTU6,P51572,O00461,Q9BZG1,Q9NPR9,Q10472,O14828 36 +Hrd1p ubiquitin ligase erad l complex 0.8579027475428087 2.1956560306939115 0.0281165725359509 0.9999999999932704 0.266959457130818 5 Q6NTF9,Q9UBV2,Q9GZP9 3 +Er ubiquitin ligase complex 0.8579027475428088 2.1956560306939115 0.0281165725359509 0.9999999999932704 0.266959457130818 5 Q6NTF9,Q9UBV2,Q9GZP9 3 +Nadh dehydrogenase complex 0.5544283176227369 2.1501577959027443 0.0315427352302339 0.9999999999997216 0.2856510534309084 24 Q9P0J0,Q96CU9,O95168,O95299,O96000,Q86Y39,Q9Y6M9,P03886,O43676,O95139 10 +Organelle membrane contact site 0.606369983745958 2.1485683706736 0.0316686312007659 0.9999999999997524 0.2856510534309084 17 O96008,Q5XKP0,Q15388,Q9Y320,P51572,Q96N66,P27824,Q96S66 8 +Endoplasmic reticulum 0.5869731574210741 2.1373205577193146 0.0325719279084979 0.9999999999998932 0.2894848309551894 488 Q969V3,O15498,Q96PC5,Q07065,Q9NR31,Q9H6V9,Q9NQC3,Q86XL3,Q9P2W9,Q9H1A3,Q15800,P80303,Q5T9L3,O15173,Q9UM00,Q8TDW0,O60725,Q12959,O95070,O95197,P61026,P09601,P24390,P04439,P30519,P43307,P13674,Q6PIU2,Q13510,P51648,Q16850,O95470,P04843,O15118,Q96CS3,O75844,Q9Y282,P84095,P62820,Q4ZIN3,Q8NBI6,Q8NBQ5,Q99442,Q02818,P04062,Q8WXH0,Q8TCT9,P51571,Q99720,Q14108,Q8N2K0,O60858,Q8N5M9,Q14257,O00767,P20073,Q8N511,Q70UQ0,Q9NX47,Q86YN1,O00165,Q96AY3,O75396,Q9HD20,Q9BUR5,Q96S52,Q96A33,Q8IV08,Q969X5,O00264,Q8N5B7,Q5H8A4,Q9Y5M8,P46977,Q06136,O00400,Q15363,P38435,Q96HE7,Q15392,Q9BRR6,Q9BT22,Q8NHP6,Q92542,Q9Y3D6,Q96G23,Q7Z2K6,Q9UKU0,P10619,P56589,Q9H6H4,P07099,Q9UBV2,Q9GZP9,P16615,Q9Y3B3,O43852,P53634,O75477,Q8N2F6,Q9UGP8,Q9BZF3,Q8TB61,Q92791,Q9P035,Q9Y4P3,P26885,Q9UNK0,Q9NPA0,Q9HCU5,Q12768,P27105,O43493,O76024,P67812,Q96JJ7,Q8NHH9,Q01105,Q96A57,Q14534,P55327,Q16880,Q8TCT8,O75503,Q9Y3E0,Q96LJ7,Q15041,Q15125,Q14739,P37268,P51572,Q5VV42,Q9H3N1,P04035,Q10472,Q96S66,Q9Y680,P35613,Q8NF37,Q9Y6Y8,Q6P179,P52789,O43681,P57088,Q99640,Q96AA3,Q99797,O15269,P05023,Q9NZ01,Q15005,Q96RL7,O95674,P98194,P50402,P05067,Q12981,Q9BVG9,Q04656,P16435,Q5JRA6,Q9NZ08,Q9Y6I9,O95433,Q53GQ0,P27824,P61916,Q5BJF2,Q7Z3C6,O75298,O14681,Q99735,Q9NWM8,Q9BVK6,Q13641,Q00765,P49755,P04637,Q15904,Q9NP58,Q7L0J3,Q04323,Q6UX53,O15258,Q6NTF9,P48723,Q8IY95,P30536,Q9Y296,Q96N66,Q15006,O75787,Q92604,Q92643,Q9BU23,Q03519,Q9Y394,Q96KC8,Q9BUN8,Q9Y320,O14656,Q86UE4,Q9NRR5,Q9NUQ2,O15460,P48651,Q9UBM7,Q9BRK5,Q6NUQ4,Q15382,P52292,P35573,Q03518,P10321,O00584,Q8TED1,Q9NTJ5,Q99828,Q96HY6,Q16799,Q96AG4,O94905,Q9BTY2,A1L0T0,O75915,Q2TAA5 226 +Respiratory chain complex iii 0.7423703594824895 2.1314299141622306 0.0330537406317015 0.999999999999932 0.2894848309551894 8 O14949,Q9UDW1 2 +Pore complex 0.7410135842191763 2.1247379306407663 0.0336084865705232 0.9999999999999596 0.2914889892943462 8 Q9Y277,P45880,P21796,O96008,P12235 5 +Golgi lumen 0.8403687985560799 2.120838655050944 0.0339353825024133 0.99999999999997 0.2915210954016842 5 O00461,P05067,Q9NX62 3 +Phagocytic vesicle 0.5069534882831934 2.104468090146453 0.035337635296945 0.999999999999992 0.2967307185014217 43 Q86Y82,P51809,Q9UKG1,P61026,Q03519,P04439,Q9UNK0,Q04656,Q01968,P11279,P61421,Q03518,P10321,Q6ZWJ1,P08670,P51790,P50570,Q93050,O75396,Q9BZG1,Q9Y487,P13473 22 +Mitochondrial protein containing complex 0.5083285826820998 2.1000139315632156 0.0357276156230643 0.9999999999999944 0.2967307185014217 157 O14949,Q9P0J0,P06576,P20674,Q7Z7H8,Q8N4H5,P56385,Q9NVH1,P05141,Q9NS69,Q9UDW1,P09622,P03886,P40939,Q567V2,P22695,O43676,O95139,O60830,O14925,P14406,O14548,Q9Y5J9,P24539,P08574,Q96CU9,Q9Y512,Q13505,Q16891,P00403,Q99643,Q6UXV4,P21796,Q86Y39,O96008,Q9Y5J6,Q99623,Q15388,P13073,Q96IX5,O95168,O95299,O96000,O75964,Q9Y6M9,Q9NX63,Q9BPX6,O75431,P21912,P12236,Q8IWA4,Q5XKP0,Q9BUR5,Q53H12,P51970,P12235,P35232 57 +Pigment granule 0.4364009401675717 2.0988952420649065 0.0358261363776468 0.9999999999999948 0.2967307185014217 61 O43852,P11279,P62820,P55209,Q93050,P57088,P49755,Q92542,Q9NP58,P27824,O14773,P27105,O75955,P05023,P04843,P35613,P54709,Q04656 18 +Lumenal side of membrane 0.6905030168890377 2.098537359788154 0.035857703233542 0.999999999999995 0.2967307185014217 10 P04439,P51572,P10321,P27824,Q8TCT8,P10619 6 +Mitochondria associated endoplasmic reticulum membrane 0.6817355845080352 2.05172549230082 0.0401963478418629 1.0 0.3153476785328764 10 Q9Y320,P51572,Q96N66,P27824,O96008,Q96S66 6 +Integral component of synaptic vesicle membrane 0.7823227690116444 2.0364398466082485 0.0417062076540517 1.0 0.3215299085808092 6 Q86Y82,O76024,Q7L0J3,O60499 4 +Microbody 0.4453808422587033 2.006584663540471 0.0447939056600721 1.0 0.3339182058296286 57 Q96CN7,Q8N4Q0,Q9Y3D6,P56589,Q9UKU0,P40855,Q5T8D3,P28288,Q9BY49,P39210,P51648,P14735,P33121,Q9NR77,Q8TB36,Q969V5,P08670,Q6YN16,O43808,O00116,P04035,O15254,O15228,O75381 24 +Atpase dependent transmembrane transport complex 0.805855196617772 1.971786303173552 0.0486340065802992 1.0 0.3509429914834395 5 P05023,Q9NUT2,Q9NP58 3 +Transport vesicle membrane 0.4902688378248178 1.9361161285210944 0.0528534795979609 1.0 0.3611654439193997 42 Q86Y82,Q9Y6Y8,Q15363,O43760,O60499,P62820,P04439,P49755,Q9NR31,O75396,P10321,Q7L0J3,P20020,O76024 14 +Lumenal side of endoplasmic reticulum membrane 0.7008877531631854 1.9245296278075703 0.0542882306885115 1.0 0.3654327170226671 8 P04439,P51572,P10321,P27824,Q8TCT8 5 +Haus complex 0.7918321842609076 1.9105626897777663 0.0560608029341445 1.0 0.3745692166414692 5 Q96CS2,Q9H6D7,O94927 3 +Tim23 mitochondrial import inner membrane translocase complex 0.7910663814966771 1.9072084259033184 0.0564936028201528 1.0 0.3746855128218958 5 O60830,O14925,P12236 3 +Endocytic vesicle membrane 0.4753455694161834 1.8808417859505475 0.0599934440740732 1.0 0.3896476067387882 45 P61026,Q03519,P11279,Q14108,Q93050,Q03518,P10321,Q5KU26,Q9BZG1,Q9Y487,P13473,Q5T9L3,O43493,Q04656,Q8WTV0 15 +Proton transporting atp synthase complex coupling factor f o 0.7370129301820352 1.827252557149702 0.0676618049145922 1.0 0.4174201507479286 6 P24539,O75964 2 +Mitochondrial proton transporting atp synthase complex coupling factor f o 0.7717698185209266 1.822325487990097 0.0684056130468757 1.0 0.4174201507479286 5 P24539,O75964 2 +Proteasome core complex beta subunit complex 0.7027061634480867 1.794242231459758 0.0727745141824287 1.0 0.4347192833943757 7 P49721 1 +Trans golgi network membrane 0.4835250923079702 1.7573150615072364 0.0788641219670358 1.0 0.45521990554474 36 O60499,Q9NX62,P05067,Q8N2H4,O15127,P35670 6 +Neuromuscular junction 0.5243654205794459 1.7509658435492592 0.0799517937377325 1.0 0.45521990554474 20 P10644,O43760,P07196,Q14168,Q7L0J3,P05067,P57105,Q12959 8 +Late endosome membrane 0.4827608604376153 1.7346487720753765 0.0828030351483444 1.0 0.4557169513154929 35 P11279,Q15043,Q8TCT8,Q8IV08,Q7Z3C6,P13473,Q14108,P51790,O15118 9 +Chloride channel complex 0.7513035436889044 1.7315561366889982 0.0833526216989666 1.0 0.4557169513154929 5 Q9C0H2,P51798,Q96S66 3 +Autophagosome 0.4823105034472909 1.6638558041996083 0.0961412489056081 1.0 0.4927239006412418 30 Q969Q5,P11279,Q9Y6I9,Q96A57,Q9Y371,O75787,Q7Z3C6,P13473 8 +Cytoplasmic ubiquitin ligase complex 0.6452496540890883 1.6397917796475532 0.1010484679725407 1.0 0.509193955928669 8 Q6NTF9,Q9UBV2,Q9GZP9 3 +Retromer complex 0.6429244972943633 1.627722186959544 0.1035838063926417 1.0 0.5165400371067148 8 Q9UNH7,Q9Y5X3,O60749 3 +Dendrite membrane 0.8281007149518189 1.6258556230634515 0.1039803723382295 1.0 0.5165400371067148 4 Q14168,P20020,O75787 3 +Triglyceride rich plasma lipoprotein particle 0.9658278968623786 1.623175430206146 0.1045519085377071 1.0 0.5165400371067148 2 Q9UHG3 1 +Golgi medial cisterna 0.8271681691016418 1.622029996713127 0.1047969254883911 1.0 0.5165400371067148 4 Q16706,O95249,P04439 3 +Intrinsic component of vacuolar membrane 0.9636533084808934 1.6142726397170204 0.1064683019974759 1.0 0.5219261326180613 2 O15118 1 +Rough endoplasmic reticulum membrane 0.5225986272895391 1.5989240824219233 0.1098374722654491 1.0 0.5269438285533986 17 P51571,Q96A33,Q9Y5M8,Q15041 4 +Proton transporting v type atpase complex 0.5720037981307454 1.5887949578489255 0.1121066919990665 1.0 0.5269438285533986 12 Q8N511,Q93050,P61421,P36543,Q15904,O75787,Q9Y487 7 +Sec61 translocon complex 0.8182468711915147 1.585388262070757 0.1128781464366412 1.0 0.5269438285533986 4 P51571 1 +Translocon complex 0.8182468711915147 1.585388262070757 0.1128781464366412 1.0 0.5269438285533986 4 P51571 1 +Protein lipid complex 0.7174476553073967 1.5798456392364228 0.1141422208832887 1.0 0.5269438285533986 5 Q9UHG3 1 +Intrinsic component of presynaptic membrane 0.7170433044112283 1.578022827964066 0.1145603655396461 1.0 0.5269438285533986 5 P27824,P20020,Q92542 3 +Presynaptic active zone 0.518713484253141 1.5726559853409092 0.115798496648237 1.0 0.5269438285533986 17 Q99623,Q7L0J3,P27824,P05067,P20020,O75955 6 +Paraspeckles 0.6825141963438579 1.569965429254613 0.1164231542083609 1.0 0.5269438285533986 6 Q8WXF1,P23246 2 +Membrane protein complex 0.5372026144036756 1.5698911073535498 0.1164404467784994 1.0 0.5269438285533986 286 O14949,Q86Y82,O15498,P20674,Q8N4H5,Q9NVH1,P05141,Q9C0H2,Q9NR31,Q9NS69,Q9P2W9,Q9UDW1,Q4KMQ2,P03886,Q8TDW0,O43676,Q12959,O60830,P14406,P04439,P08574,P24539,P45880,Q13505,Q99643,P21796,Q86Y39,O95249,P04843,Q96CS3,O60499,P13073,Q9Y277,Q8WXH0,Q8TCT9,Q9Y6M9,O75964,P51571,Q9UNH7,Q8N2K0,P54709,P50148,Q8N511,Q5XKP0,Q93050,O75396,Q9BUR5,Q96S52,Q9Y487,O75306,Q9Y5M8,P46977,Q92542,Q9UBV2,Q9GZP9,O14548,Q96CU9,Q6UXV4,Q9NPA0,P51798,Q9Y5J6,P67812,Q99623,Q15041,Q8IWA4,Q53H12,Q96S66,Q9P0J0,O15269,P05023,P22695,Q15005,O14925,Q9Y512,Q16891,P00403,Q12981,O60749,O15400,O95168,Q53GQ0,Q9NX63,O75431,P12236,P49755,Q15904,Q9NUT2,Q9NP58,O75955,Q04323,P12235,Q6NTF9,O00203,P06576,Q9UH99,P56385,Q15006,O75787,Q9Y5X3,O95139,Q92643,Q03519,Q9BUN8,O96008,P63218,Q15388,Q96IX5,Q03518,P10321,O95299,O96000,Q9BPX6,P21912,P51970,P35232 115 +Rough endoplasmic reticulum 0.4591564154273638 1.5527994088018415 0.1204710640006321 1.0 0.5406213916844287 36 Q07065,Q5VV42,P27824,P05067,Q96A33,P51571,Q15041,Q9Y5M8 8 +Coated vesicle 0.3951133730369658 1.5405046202485797 0.1234373974644351 1.0 0.5464146191737873 89 O95070,Q9Y6Y8,Q9Y282,Q8N511,Q15363,Q9BVK6,P24390,O00165,P42892,O43493,P51572,P49755,Q5VW38,P05067,Q14108,Q04656 16 +Mitochondrial intermembrane space protein transporter complex 0.9419074246660448 1.5251926007434566 0.1272110656008729 1.0 0.5464146191737873 2 Q9Y5J9 1 +Trans golgi network 0.3790425054249051 1.5159699153071862 0.1295269597948352 1.0 0.5464146191737873 76 P98194,O60499,Q9NX62,Q96A57,Q96ED9,P05067,P04062,Q8N2H4,O15127,O43493,P35670,Q04656 12 +Secondary lysosome 0.9394221808014892 1.515008900411541 0.1297701501602923 1.0 0.5464146191737873 2 P13473 1 +Autolysosome 0.9394221808014892 1.515008900411541 0.1297701501602923 1.0 0.5464146191737873 2 P13473 1 +Postsynaptic density membrane 0.5959473277539603 1.5140668638476225 0.1300088818504585 1.0 0.5464146191737873 9 Q14168,P23634,Q99720,P57105,Q12959 5 +Nuclear lamina 0.7021595150144085 1.510763435858169 0.1308487336380688 1.0 0.5464146191737873 5 P02545 1 +Specific granule 0.4599620673100205 1.4942957410408553 0.1350983378282422 1.0 0.5564324233839016 31 P30519,Q07065,O00264,P27105,P51790 5 +Vacuolar proton transporting v type atpase v0 domain 0.790481513012946 1.4708985384622053 0.1413185579907618 1.0 0.5665303969229654 4 Q9Y487,Q93050 2 +Proton transporting v type atpase v0 domain 0.790481513012946 1.4708985384622053 0.1413185579907618 1.0 0.5665303969229654 4 Q9Y487,Q93050 2 +Endoplasmic reticulum quality control compartment 0.660242276078597 1.463253248424668 0.1433980952387292 1.0 0.5698021229309859 6 P27824,O60858 2 +Tim22 mitochondrial import inner membrane insertion complex 0.9245107176141644 1.4539134332400463 0.1459703080094725 1.0 0.5749572830766123 2 Q9Y5J6 1 +Derlin 1 retrotranslocation complex 0.7855649272224213 1.4505641223485222 0.1469012717516462 1.0 0.5761084657390648 4 Q9UBV2,Q9BUN8 2 +Intrinsic component of nuclear inner membrane 0.6562496634631941 1.444040734952079 0.1487275172310016 1.0 0.580745543473435 6 O94901,Q5SNT2,Q9UH99,Q14739 4 +Gtpase complex 0.6304573238873057 1.4354618258539291 0.1511555389621328 1.0 0.5851600692868835 7 P50148,P63096,P63218,P04899 4 +Zymogen granule 0.7725948755700518 1.3968518694702428 0.1624581206430735 1.0 0.6030338469961001 4 Q15363 1 +Sarcolemma 0.4504089179630605 1.381712577234542 0.1670599710293563 1.0 0.6074886949902965 27 O75298,P11279,Q92542,P35613,O75955,P05023,Q99828,Q12959 8 +Basolateral plasma membrane 0.4169721177815797 1.3680877802045788 0.1712846012141782 1.0 0.6074886949902965 46 Q9Y289,P78310,P20020,P55011,P05023,Q12959,Q14168,P23634,P14735,P57105,P35670,Q04656,P53985,Q15043,P30825,Q6P4Q7,P54709,P04920,O75955,P35613 20 +Envelope 0.5306125980853744 1.3590638200212546 0.1741263662885435 1.0 0.6074886949902965 490 O14949,Q9BSK2,Q9BQ95,Q69YU5,P20674,Q7Z7H8,Q8N4H5,Q9NVH1,Q9NVT9,Q9H061,Q9H2D1,Q9NQC3,Q9NS69,Q9UDW1,Q9Y2R0,P80303,P03886,O15173,O43169,O43676,O60830,P09601,P14406,P24539,P45880,Q13505,P21796,Q96A26,Q86Y39,Q13423,P57105,O15118,O95202,O75844,P02545,Q8N8Q8,Q70HW3,P13073,Q9Y277,Q9Y371,Q15070,O75964,Q9Y6M9,O75208,Q99720,Q8WWV3,Q5XKP0,Q9NX47,O00165,Q9UBX3,Q9HCL2,Q9NZJ7,Q9BUR5,O00264,P16260,P42167,Q7KZN9,Q8NAN2,Q9UKU0,P40939,Q567V2,P41208,P22830,O14548,Q8N2A8,Q9Y5J9,Q96CU9,Q9P035,Q6UXV4,Q9Y5J6,Q6KCM7,Q5SNT2,Q99623,Q9H3K2,Q8TB36,Q9BQT8,Q969V5,Q9BWH2,Q15125,Q14739,Q8IXI1,Q9UG56,Q8IWA4,P52888,Q9UJS0,Q53H12,Q96S66,Q9Y619,Q9P0J0,Q9NVI7,Q9H9P8,P52789,P57088,Q07820,O43819,Q10713,P22695,Q96RL7,O95674,O14925,Q6NUK1,Q96H78,P50402,Q9Y512,Q16891,P00403,P05067,P39210,Q86UT6,Q9P0S9,Q9BTX1,Q9H2V7,Q12981,P20700,O95168,Q5BJF2,Q9NX63,O14681,O75431,P23786,Q99735,P12236,Q8NBN7,Q9NUT2,Q9NP58,O75880,P53701,P12235,Q96AQ8,O60313,P06576,Q9HC21,Q9UH99,P56385,Q14728,P30536,O43615,P53007,Q9Y6C9,O95139,Q96KC8,Q9Y320,O75323,O14656,Q03252,Q86UE4,Q9C0E2,Q9NUQ2,Q5T9A4,P50416,O96008,Q9UBM7,Q7Z569,O95831,Q15388,Q96IX5,Q8TD16,O95299,O00584,O96000,Q8NFH4,Q9BPX6,P21912,Q8NFH5,O95140,O75746,Q96AG4,P51970,P35232 169 +Er to golgi transport vesicle membrane 0.4681867626481761 1.3469023967390403 0.1780116695322653 1.0 0.6074886949902965 20 Q9Y6Y8,Q15363,P49755,P04439,Q9NR31,O75396,P10321 7 +Golgi associated vesicle 0.4375966724403016 1.3424367958592145 0.1794544107653388 1.0 0.6074886949902965 34 Q9BVK6,Q8N511,Q15363,P24390,P05067,Q8TCT8,O43493,Q04656 8 +Vacuole 0.4806704266739299 1.342299645697416 0.1794988582701213 1.0 0.6074886949902965 212 P11117,Q8IY95,P38435,O43681,O00203,Q07065,Q92542,P54802,O75787,P09622,P06865,P10619,Q96RL7,Q8WTV0,P16278,P50897,P07602,P17900,Q9UIQ6,P42892,Q8NHP8,P06280,Q9UM22,Q9NRR5,Q13510,P27105,Q9H7Z7,Q9NQX7,Q9H2V7,Q9UHG3,P51798,O60749,O15118,Q969Q5,Q15165,Q15382,P11279,Q9NX40,Q9Y6I9,O15400,Q96A57,Q9Y371,Q15043,P04062,Q8TCT8,O75503,P61916,Q5BJF2,Q8NCG7,Q7Z3C6,Q14108,P51790,Q8N511,Q93050,Q9NZJ7,Q9NP58,P10253,Q8IV08,Q9Y487,O75955,P13473,Q8NF37 62 +Clathrin coated vesicle 0.4037306213359052 1.3150371020775844 0.1884974334867066 1.0 0.6074886949902965 49 Q9BVK6,Q14108,P49755,P42892,O00165,P51572,Q5VW38,O43493,Q04656 9 +Caveola 0.4913416626903916 1.3141580668035706 0.18879301666867 1.0 0.6074886949902965 15 O75955,P09601,Q8WTV0 3 +Gpi anchor transamidase complex 0.6577271435516453 1.3083727369935283 0.1907469150441156 1.0 0.6074886949902965 5 Q96S52,Q92643 2 +Intrinsic component of peroxisomal membrane 0.6575866203359686 1.307729658926504 0.1909650198741328 1.0 0.6074886949902965 5 Q9Y3D6,P56589,O43808 3 +Gamma secretase complex 0.8884746815781246 1.3065402077546522 0.1913689149381712 1.0 0.6074886949902965 2 Q92542 1 +Organelle envelope lumen 0.4317880742268415 1.305303052677566 0.1917896750098449 1.0 0.6074886949902965 35 O60313,O14925,O95831,P52888,Q9Y5J9,O00165,Q96AY3,Q16891,O00584,P05067,Q53H12,P51970,Q9BRT2,Q9BPX6,Q9Y5J6 15 +Tertiary granule membrane 0.5471046180339828 1.303307332154674 0.1924698588907556 1.0 0.6074886949902965 10 P10253,O75787,Q08722,P27105 4 +Endosome lumen 0.7497563726125342 1.3020944700285364 0.1928840933375644 1.0 0.6074886949902965 4 Q9UIQ6 1 +Atp binding cassette abc transporter complex 0.8866107486797146 1.2989375894021655 0.1939653482895846 1.0 0.6074886949902965 2 Q9NUT2 1 +Chitosome 0.8736312248264393 1.2829282220878322 0.1995172242938725 1.0 0.6082396776995429 3 Q04656 1 +Endoplasmic reticulum tubular network membrane 0.8734594788892587 1.2822667348373074 0.1997490929845611 1.0 0.6082396776995429 3 Q9NQC3 1 +Mitochondrial permeability transition pore complex 0.7427522551192101 1.2730093764851722 0.2030147146174448 1.0 0.6082396776995429 4 P12235,P21796 2 +Microtubule organizing center attachment site 0.7425677009631247 1.2722429448797636 0.2032868134770489 1.0 0.6082396776995429 4 Q8WXH0,Q9UH99 2 +Copi coated vesicle membrane 0.5081632914249627 1.2712333172625097 0.2036456570568314 1.0 0.6082396776995429 13 P24390,Q8N511 2 +Emc complex 0.8691144494621988 1.2655354552254603 0.2056794469979825 1.0 0.6082716760399354 3 Q9NPA0 1 +Smooth endoplasmic reticulum 0.5292054562311119 1.263271882394069 0.2064914874844761 1.0 0.6086775219313643 11 P05067,O00264 2 +Platelet alpha granule 0.4763622285371349 1.2468722379214117 0.2124443476910986 1.0 0.6190337666888628 16 Q96JJ7,Q9Y6I9,Q9NTK5,Q8NBX0,Q6UXV4,P05067,Q9H267,P51809,Q9NUQ9 9 +Basal part of cell 0.3852885026596371 1.2422150137145904 0.2141572416813819 1.0 0.6211248617254229 53 Q9Y289,P78310,P20020,P55011,P05023,Q12959,Q14168,P23634,P14735,P57105,P35670,Q04656,P53985,Q15043,P30825,P42785,Q6P4Q7,P54709,P04920,O75955,P35613 21 +Postsynaptic specialization membrane 0.5029799100018375 1.23868159484165 0.2154634373615225 1.0 0.6229103221156836 13 P52292,Q14168,P23634,Q99720,P57105,Q12959 6 +Oligosaccharyltransferase complex 0.5883104963846272 1.22194705192039 0.2217276505710459 1.0 0.6288793112442025 7 P46977 1 +Dendritic shaft 0.6097035985544321 1.2186184050243074 0.2229890601237905 1.0 0.6288793112442025 6 Q14168 1 +Extrinsic component of endoplasmic reticulum membrane 0.8667287977632805 1.2180398401567674 0.2232088333884152 1.0 0.6288793112442025 2 Q15006 1 +Extrinsic component of organelle membrane 0.4970129440587963 1.201138186286495 0.2296976024659403 1.0 0.6355436730806079 13 Q15006,Q9Y5X3,O14656 3 +Blood microparticle 0.4660487284508601 1.176440391785986 0.2394189389781849 1.0 0.6504695269829 16 P04062,P38435 2 +Ciliary transition zone 0.5990540391051028 1.1667843173375736 0.2432974818489688 1.0 0.6570488881070954 6 P41208,Q15154,Q15555,Q15051 4 +Neuron projection membrane 0.531865073090905 1.1574263831678626 0.2470982000966666 1.0 0.6613726305257961 9 Q14168,P20020,O75787 3 +Presynaptic active zone membrane 0.6235575674840461 1.151707179704458 0.2494414209497024 1.0 0.6637054917304767 5 P27824,P20020 2 +Presynapse 0.3654936519813967 1.1387298872128224 0.2548158330285648 1.0 0.6700987795678294 93 Q86Y82,P07196,Q92542,Q9Y296,P20020,Q92905,P61026,P50897,O14656,P05067,O76024,P11279,O43760,O60499,Q99623,O15400,Q96A57,P27824,P51790,Q9BVK6,Q13641,Q7L0J3,O75955,Q9BT78 24 +Copi coated vesicle 0.4741269042951976 1.1245474682652477 0.2607808449002844 1.0 0.6767208411409689 14 P24390,Q8N511,Q15363 3 +Mitotic spindle microtubule 0.566656485558682 1.1115782817480209 0.2663195147889539 1.0 0.6767859210337396 7 Q96CS2,Q9H6D7,O94927 3 +Cell body membrane 0.8278433809819767 1.1072061173237635 0.2682048233173226 1.0 0.6767859210337396 3 P20020,P55011 2 +Dendritic spine membrane 0.8278433809819765 1.1072061173237635 0.2682048233173226 1.0 0.6767859210337396 3 P20020,O75787 2 +Side of membrane 0.3428484076434152 1.1059315425533631 0.2687561509589917 1.0 0.6767859210337396 74 P20020,O75787,P10619,Q9Y5X3,Q12959,P17900,P04439,P42892,P63218,P11279,P10321,P27824,Q8TCT8,O96005,Q8TCT9,P51790,P50148,P51572,O75955,P11413 20 +Brush border membrane 0.5124404405437519 1.1035160011099638 0.2698031466926529 1.0 0.6767859210337396 10 P40855,Q14728,Q04656 3 +Tubular endosome 0.7015674748444255 1.1021418119505682 0.2704000242523539 1.0 0.6767859210337396 4 Q9Y5X3 1 +Platelet alpha granule lumen 0.5011079567078872 1.0964300556345878 0.2728906169439913 1.0 0.6772240787498411 11 Q6UXV4,P05067,Q8NBX0 3 +Golgi associated vesicle membrane 0.4285750873572118 1.0955124360222277 0.2732922002937274 1.0 0.6772240787498411 21 P24390,Q8N511,Q15363 3 +Lamin filament 0.8193985466326422 1.075007281119453 0.2823714684943628 1.0 0.6911976783363375 3 P02545 1 +Intermediate filament 0.4240052253938023 1.0607761813779106 0.2887916292011567 1.0 0.6911976783363375 21 P02545,P20700,P07196,Q16352,O75298,P08670,P07197 7 +Prefoldin complex 0.688495200521528 1.0481081771228655 0.2945887692741586 1.0 0.6911976783363375 4 Q9UHV9,Q99471 2 +Multivesicular body 0.46187484991803 1.044591697558252 0.2962117184384865 1.0 0.6911976783363375 14 Q96PU5,P11279,Q9NP58 3 +Cell surface 0.3421051808116522 1.0443772171698202 0.2963109000928818 1.0 0.6911976783363375 78 P06576,O75787,Q4KMQ2,O75330,Q8WTV0,P04439,P42892,P05067,O43847,Q96JJ7,P11279,Q99623,P10321,O96005,O75298,P51790,Q13641,Q08722,O75955,O15258,P35232 21 +Apical plasma membrane 0.3735067227757863 1.0389866377884789 0.298810950769754 1.0 0.6911976783363375 50 Q9Y289,Q99797,P20020,O75787,P55011,P05023,Q12959,P23634,Q86UE4,Q04656,P61421,P53985,P36543,Q15043,P30825,Q99828,P54709,P51790,O00165,P04920,O75955 21 +Endoplasmic reticulum exit site 0.4366350104053498 1.0384556722199745 0.2990579622972973 1.0 0.6911976783363375 18 P04439,Q96PC5,Q5JRA6,Q9NR31 4 +Plasma membrane raft 0.4240193810586228 1.0201605572569266 0.307652320469161 1.0 0.6956067987780057 20 P10644,O75955,P09601,Q8WTV0 4 +Integral component of cytoplasmic side of endoplasmic reticulum membrane 0.8148493320907021 1.00963140241674 0.3126719188258458 1.0 0.7031346004557838 2 Q8TCT8 1 +Cation transporting atpase complex 0.7971772163023694 0.9907669640814412 0.321799384101489 1.0 0.7113197378678883 3 P05023 1 +Sodium potassium exchanging atpase complex 0.7971772163023694 0.9907669640814412 0.321799384101489 1.0 0.7113197378678883 3 P05023 1 +9plus2 motile cilium 0.4030122510534855 0.9857432606886374 0.3242591149396778 1.0 0.7133700528672913 23 P10644,P41208,Q9GZT3,Q15388,P23634,P05023,Q96RL7 7 +Photoreceptor connecting cilium 0.5858017446109817 0.9786677878366008 0.3277441531324374 1.0 0.7175369566151907 5 P41208,Q15555,Q15051 3 +Anchored component of synaptic vesicle membrane 0.5848880597014866 0.9744932065828746 0.3298117105824962 1.0 0.7182669971191751 5 P20337,P61020,P20339,Q15286 4 +Cis golgi network membrane 0.805219012115556 0.971573386145641 0.3312628279396639 1.0 0.7182669971191751 2 P98194 1 +Early endosome 0.358736345675839 0.9605435698939088 0.336781713737933 1.0 0.7189550749472742 101 Q86Y82,Q92542,Q5T9L3,Q9Y5X3,Q9GZP9,Q9UIQ6,Q9BUN8,P04439,Q9BZF3,Q5VW38,Q9UNK0,Q13510,Q12768,P05067,O60749,Q04656,Q01968,P62820,O15400,Q96A57,P10321,Q15043,Q96PE3,Q9UNH7,Q92543,P51790,Q96L92,Q567U6,Q9NP58,Q8IV08,P31751,O75955,P35232 33 +Early endosome membrane 0.3664612217475059 0.9442451998264976 0.3450443623665726 1.0 0.7271729319033845 49 Q86Y82,Q96L92,P04439,O15400,P10321,Q15043,Q9NP58,Q92543,Q96PE3,Q8IV08,Q5T9L3,P51790,Q9Y5X3,O60749,Q04656 15 +Er membrane insertion complex 0.7784338098197668 0.9204076556995328 0.3573597694774948 1.0 0.7409277436971717 3 Q7L5D6,P46379 2 +Signal peptidase complex 0.7777385926215177 0.9178125891448032 0.35871699024944 1.0 0.7409277436971717 3 P67812 1 +Zymogen granule membrane 0.7743168170738164 0.9050567292701972 0.3654353342431315 1.0 0.7461994254875176 3 Q15363 1 +Integral component of presynaptic active zone membrane 0.6515299451144896 0.8965338146379895 0.3699677287608811 1.0 0.746556803897796 4 P27824,P20020 2 +Intrinsic component of presynaptic active zone membrane 0.6515299451144896 0.8965338146379895 0.3699677287608811 1.0 0.746556803897796 4 P27824,P20020 2 +Perinuclear endoplasmic reticulum 0.5376044224169334 0.8681503825215885 0.3853120126865696 1.0 0.7655317961305856 6 O60858 1 +Photoreceptor inner segment 0.5591302809618905 0.8573222435809926 0.3912668187101698 1.0 0.76775096925808 5 P35613 1 +Proteasome core complex 0.4323495446317356 0.8516165732224348 0.3944269379987266 1.0 0.76775096925808 14 P49721 1 +T tubule 0.4965576772699349 0.8509738457604739 0.3947838815523863 1.0 0.76775096925808 8 O75298,P05023 2 +Neurofilament 0.6389066678104778 0.8453849668820786 0.39789593517829 1.0 0.76775096925808 4 P07196,P07197 2 +Acrosomal membrane 0.7726001863932784 0.8447843351695133 0.3982312623090189 1.0 0.76775096925808 2 P35613 1 +Trans golgi network transport vesicle 0.4213389766415495 0.8430819482210257 0.3991826138719681 1.0 0.76775096925808 15 O43493,Q9BVK6,Q04656 3 +Immunological synapse 0.4345963574466317 0.8063759838530363 0.4200260902806321 1.0 0.7779538674191584 13 P10644,O15400,P20020,Q96L92 4 +Uniplex complex 0.7417650714729592 0.7853149357605521 0.4322689409248066 1.0 0.7892560057336768 3 Q9BPX6,Q8NE86 2 +Recycling endosome 0.3617045281942715 0.7705928844258249 0.4409482801492279 1.0 0.7936661101085127 42 Q86Y82,P61026,P04439,O15400,Q96A57,P10321,P05067,O14773,Q96PE3,Q7Z3C6,O15127,P51790,O14828 13 +Ficolin 1 rich granule membrane 0.3930268056369582 0.7560947557204735 0.4495923860072437 1.0 0.7961477474176619 19 P11279,Q93050,P10253,O75787,P13473 5 +Mhc class i peptide loading complex 0.5363795805359736 0.7550556616552573 0.4502155852013711 1.0 0.7961477474176619 5 Q03519,Q03518 2 +Apical part of cell 0.3065345843825983 0.7368735261045893 0.4611992648088732 1.0 0.8062049163907047 64 Q9Y289,Q99797,P20020,O75787,P55011,P05023,Q12959,P41208,P23634,Q86UE4,P05067,Q04656,P61421,P53985,P36543,Q15043,P30825,Q99828,P54709,P51790,O00165,P04920,O75955 23 +Azurophil granule lumen 0.3628452097452549 0.7322799693729233 0.4639977026692681 1.0 0.807831931802846 38 O00754,P16278,P53634,P34059,O43681,P17900,P15586,P06280,O00584,P61916,Q9H7Z7,P10619,Q9BTY2,Q96CS3 14 +Synaptonemal structure 0.4709408679941513 0.7155390278814608 0.4742760338855074 1.0 0.8133022482219158 8 Q92791,Q7Z5K2 2 +Tertiary granule 0.3551651966372568 0.709525202776375 0.4779986173265969 1.0 0.8165809712662697 42 P11279,Q93050,O15400,P09960,P10253,O75787,Q13510,P27105,P13473,Q08722 10 +Endocytic vesicle 0.3257970244468093 0.7051018814588811 0.4807468357611215 1.0 0.8178226093930564 89 Q86Y82,Q5T9L3,Q8WTV0,P61026,Q03519,Q5KU26,O43493,Q04656,Q969Q5,P11279,O15400,Q03518,P10321,P08670,Q14108,P51790,Q93050,O00461,Q9BZG1,Q9Y487,P13473 21 +Ubiquitin conjugating enzyme complex 0.6034189799364242 0.7041533203869927 0.4813372974625429 1.0 0.8178226093930564 4 Q9UNE7 1 +Hops complex 0.5248756218905402 0.7039796276134409 0.4814454607402583 1.0 0.8178226093930564 5 Q9H9C1,Q9H267,Q96AX1,Q9P253 4 +Ciliary rootlet 0.732214973594271 0.693840514582359 0.4877822317522375 1.0 0.8230326753872105 2 P05067 1 +Cortical endoplasmic reticulum 0.7291084187635778 0.6825769869019894 0.4948741799889304 1.0 0.8266231673148432 2 P50402 1 +Mhc protein complex 0.7097576134244725 0.6711850637814171 0.5021026425207611 1.0 0.8270948935575972 3 P04439,P10321 2 +Mhc class i protein complex 0.7097576134244725 0.6711850637814171 0.5021026425207611 1.0 0.8270948935575972 3 P04439,P10321 2 +External side of plasma membrane 0.3667757174868883 0.6589217082322704 0.5099460450911557 1.0 0.8272865695543569 22 P11279,P42892,O96005,O75955,P51790 5 +External encapsulating structure 0.3569536215273162 0.6406736971926723 0.5217347067583713 1.0 0.8341525395452276 33 P20073,P07602,Q53GQ0,Q9NZJ7,Q5KU26,Q92896,Q08380,Q12959 8 +Nucleotide activated protein kinase complex 0.5101699180922616 0.6394944645008862 0.5225013135732302 1.0 0.8341525395452276 5 P10644,Q13131 2 +Sarcoplasm 0.3827322619720043 0.6279288107197359 0.530050576382884 1.0 0.8417352462981713 17 O43852,P52789,O00165,O75298,P16615 5 +Phosphorylase kinase complex 0.7076731904318043 0.6064751727640415 0.5441992638136877 1.0 0.858079411272579 2 P46020 1 +Golgi apparatus 0.4704774919603324 0.6051200592304318 0.5450992268948867 1.0 0.858079411272579 324 Q86Y82,O15498,Q8N6G5,Q9NR31,Q9P2W9,O14773,O15127,P80303,Q5T9L3,Q9UM00,Q6ZRP7,Q12959,P61026,O95070,O95197,P50897,P24390,P04439,Q96ED9,Q96L58,Q5VW38,Q8TBA6,O95249,O94923,P35670,O15118,Q9BSL1,O14578,Q9Y282,Q16739,O60499,Q9NX40,Q9Y371,Q02818,P04062,Q14108,Q93050,Q8NCH0,Q9BUR5,O00461,Q8IV08,L0R6Q1,O00400,Q15363,Q15392,Q9NX62,Q92542,Q7LGA3,Q8N2H4,Q96PU5,O43852,Q8N2A8,Q8TB61,Q9NQX7,O43493,Q96A57,O75503,Q9Y3E0,P51790,P51572,Q92896,Q10472,Q96S66,P35613,Q8NF37,Q9Y6Y8,Q99640,Q10713,P05023,Q96RL7,P16278,P98194,Q8IZA0,P06280,P05067,Q9H7Z7,Q04656,P0CG08,Q7Z3C6,O14681,Q9BVK6,P49755,Q9NP58,O15258,Q6NTF9,O00203,Q8IY95,Q8NBN3,Q9Y296,Q8N4A0,Q7Z5K2,Q14789,Q9BRK5,Q6NUQ4,Q15382,P52292,Q8TD16,P10321,Q08378,Q9NTJ5,Q99828,Q16706,Q16799,Q9BZG1,Q8TBQ9 105 +Presynaptic membrane 0.3706262036068312 0.5936337884536929 0.5527570768010386 1.0 0.8634959955883487 19 P27824,P20020,P23634,Q92542 4 +Golgi transport complex 0.4611076540136806 0.5808453445074274 0.5613446911668438 1.0 0.8699878203307442 7 Q96JB2,P83436,Q14746,Q9UP83,Q9Y2V7,P60953 6 +Endosome membrane 0.3538093490172789 0.556093443016215 0.5781469773183887 1.0 0.8823833731661365 132 Q86Y82,Q9UBB6,Q9UH99,Q92542,O75787,O15127,Q5T9L3,Q9Y5X3,Q96RL7,P61026,P04439,P42892,Q9BZF3,Q9UNK0,O60749,O15118,Q01968,Q04656,Q9H9H4,P11279,O15400,P10321,Q15043,Q8TCT8,Q96PE3,Q7Z3C6,Q9UNH7,Q14108,Q92543,P51790,Q96L92,O60831,Q93050,Q15904,Q9NP58,O00461,Q8IV08,Q9Y487,P13473,O14828 40 +Motile cilium 0.3470916230122253 0.5479366613967984 0.5837353944857564 1.0 0.8849232366826089 31 P10644,P41208,Q9GZT3,Q15388,P23634,P09622,P05023,Q96RL7 8 +Nuclear pore nuclear basket 0.453062930898913 0.5420888816687119 0.5877572776457898 1.0 0.8850702244348955 7 P41208 1 +Synaptic membrane 0.3197046222817386 0.5321168105322353 0.5946450951004592 1.0 0.8890046674868074 52 P52292,Q14168,P23634,Q92542,Q9Y296,Q9BPW8,P27824,P20020,O75787,Q8NCG7,Q15375,Q99720,P57105,P51790,Q12959 15 +Mitochondrion 0.4209007180460291 0.5291082930852405 0.5967303288336783 1.0 0.8896706720793021 625 O14949,Q9BSK2,Q3SXM5,Q69YU5,Q9BQ95,Q7Z7H8,O15498,Q8N4H5,P20674,Q9NVH1,Q9NVT9,P05141,Q9H061,Q9H2D1,P51530,Q9NS69,Q9H1A3,Q9UDW1,Q9Y2R0,Q8TAE8,P03886,O43169,O43676,O60830,Q5JRX3,P09601,P14406,Q9NRK6,O43572,P24539,P08574,P13674,P45880,Q13505,Q99643,P21796,Q9UHV9,Q96A26,Q86Y39,Q6P4A7,Q13423,O43847,P82933,P57105,P35670,O95202,Q9NUQ9,Q16134,Q8N8Q8,Q70HW3,P13073,Q9Y277,Q9Y371,Q9Y2W6,Q15070,O75648,Q8WXH0,O75964,Q9Y6M9,O75208,Q96E11,Q9BRT2,Q68CZ6,Q9H6K4,Q8WWV3,Q5TC12,Q5XKP0,Q9NX47,Q9H9B4,O00165,Q9UBX3,Q9BTU6,Q9HCL2,Q9NZJ7,Q9BUR5,O00264,P16260,Q9NUJ1,P49916,Q92542,Q7KZN9,Q8NAN2,Q9UIJ7,Q9UKU0,P40939,Q567V2,P22830,O14548,Q8N2A8,Q9Y5J9,Q96CU9,Q6UXV4,P27105,Q9Y5J6,Q6KCM7,Q99623,Q9H3K2,Q8TB36,Q9BQT8,Q969V5,Q9BWH2,Q8IXI1,Q9UG56,Q8IWA4,P52888,Q9UJS0,P51572,Q8NBX0,Q9NPH0,Q53H12,P35613,Q9Y619,Q9P0J0,Q9NVI7,Q9H9P8,P52789,Q99797,Q07820,O43819,Q10713,P22695,Q16836,Q96RL7,O95674,O14925,Q6NUK1,Q96H78,Q9Y512,Q16891,P00403,P39210,Q86UT6,Q9H7Z7,Q9P0S9,Q9H2V7,Q12981,P16435,P48163,Q15165,Q9NR77,O95168,Q7Z3C6,Q9NX63,O75431,P23786,P12236,Q8NBN7,P04637,Q9NVH6,Q9NUT2,Q9NP58,O75880,O00116,P53701,P12235,Q96AQ8,O00203,O60313,P06576,P48723,Q9HC21,P56385,P30536,O43615,P09622,P53007,Q9Y6C9,O95139,Q9Y320,O75323,Q9NUQ2,Q5T9A4,P50416,O96008,O95831,Q15388,Q96IX5,O95299,O00584,O96000,Q9BPX6,P21912,Q6YN16,Q9GZT3,O95140,O75746,Q96AG4,Q9P0J1,P51970,Q9BPW8,P35232 191 +Recycling endosome membrane 0.3441790879084635 0.5176964062904598 0.604670106008403 1.0 0.8953380024930662 23 Q86Y82,P61026,P04439,P10321,Q96PE3,Q7Z3C6,O15127 7 +Dna replication preinitiation complex 0.4088033777263862 0.5113036059706876 0.6091384804113056 1.0 0.8966811180447194 10 P33991,Q9BRT9,Q14566,Q9Y248 4 +Cop9 signalosome 0.4138940730499735 0.5026999821057009 0.6151752222787232 1.0 0.9000870214961014 9 Q9BT78,Q92905,Q7L5N1 3 +Ion channel complex 0.3595557433797806 0.4694266052754063 0.638764734982638 1.0 0.9081532865572326 17 Q9C0H2,Q9NUT2,P51798,Q4KMQ2,Q96S66,Q8TDW0,Q9BPX6,Q8N2K0 8 +Intermediate filament cytoskeleton 0.3344055744747278 0.449130468482325 0.653337542291546 1.0 0.91792907032239 33 Q3SXM5,P02545,P20700,P07196,Q16352,O75298,P08670,P07197 8 +H3 histone acetyltransferase complex 0.6548617583100305 0.433591224803674 0.6645853081893942 1.0 0.9208232687969794 2 O95696 1 +Phagophore assembly site 0.4422386982475533 0.426218044916103 0.6699489698107641 1.0 0.9239968972007786 6 Q86Y82,Q7Z3C6 2 +Nuclear pore central transport channel 0.525864462799462 0.4175947342899582 0.6762434473883736 1.0 0.9312543351821572 4 Q8NFH5 1 +Postsynaptic specialization intracellular component 0.4317262830482077 0.381334124572799 0.7029553354141804 1.0 0.9480354246744864 6 P12931,P35222,O60716,Q9UQB8,P50570 5 +9plus0 non motile cilium 0.3777918454837926 0.3778726131572897 0.7055252281993358 1.0 0.9484109624974678 11 P50148,P41208,Q15051,Q15555,P35613,Q01968 6 +Ikappab kinase complex 0.6334265299782482 0.370680649462144 0.7108754046666812 1.0 0.952954422951388 2 O14920 1 +Postsynaptic endocytic zone 0.6197576887231984 0.3331128909597213 0.7390490689842366 1.0 0.9652165261606124 2 P09496 1 +Coated vesicle membrane 0.2896248118800164 0.3247316155413663 0.7453842045534509 1.0 0.9654080832675386 57 Q9Y6Y8,Q8N511,Q15363,Q14108,P24390,P49755,Q9NR31,P10321,O43493,O00203 10 +Nucleoid 0.3156075970231149 0.3041005854924616 0.7610512607929074 1.0 0.9792699532599178 36 P06576,Q9NVI7,P05141,P45880,Q96AG4,P51530,P21796,P40939 8 +Calcium channel complex 0.4123392079295545 0.3017662882386534 0.762830231586838 1.0 0.9801607818964784 6 Q9BPX6,Q8NE86,Q15257 3 +Clathrin coated endocytic vesicle membrane 0.3369847940996783 0.2933569562802037 0.7692493227148496 1.0 0.9838354778792192 15 Q14108 1 +Nuclear pore outer ring 0.3821973233738081 0.27711448819073 0.7816921973404407 1.0 0.9972932984456542 8 P57740,Q9BW27,Q96EE3,P52948,Q8NFH3,Q8NFH4,Q8WUM0 7 +Acrosomal vesicle 0.3283779457715666 0.2655063982727685 0.7906193815725264 1.0 1.0 17 Q9Y487,P09622,P45880,P35613 4 +Mitochondrial crista 0.5733702260140261 0.2570086872792243 0.7971720668027764 1.0 1.0 3 O60313 1 +Early phagosome 0.5609073958980807 0.2275751132817085 0.819976569031535 1.0 1.0 3 P20339,Q9UKG1 2 +Postsynaptic membrane 0.3057167668282907 0.2221735544390172 0.8241787801628717 1.0 1.0 36 P52292,Q14168,P23634,Q9Y296,P27824,O75787,Q8NCG7,Q99720,P57105,P51790,Q12959 11 +Gap junction 0.461997655401193 0.2205778367608154 0.8254211597185126 1.0 1.0 4 Q99797 1 +Beta catenin destruction complex 0.4011194029850675 0.2132257826084355 0.831150859036417 1.0 1.0 5 Q9HB71,P35222,P48729,P49841 4 +Sperm midpiece 0.3842790741214663 0.1954976760043781 0.8450033568613557 1.0 1.0 6 Q96RL7 1 +Peptidase complex 0.2663546448564446 0.1921640624776317 0.8476136952339224 1.0 1.0 62 P67812,O00231,P28072,P61289,O75486,P54725,P49721,Q15005,Q92643 9 +Gemini of coiled bodies 0.3813250758625321 0.1850154665725504 0.8532169044320175 1.0 1.0 6 P57678,Q16637,Q9NWZ8 3 +Phagophore assembly site membrane 0.4477655348918794 0.1833773909820317 0.8545019144437926 1.0 1.0 4 Q7Z3C6 1 +Myelin sheath adaxonal region 0.5511028269648925 0.1784017565208785 0.8584074699292923 1.0 1.0 2 Q12846 1 +Exocyst 0.3760497667185014 0.1666614565308664 0.8676364345286729 1.0 1.0 6 O60645,Q8IYI6,Q9UPT5,Q8TAG9,Q96KP1 5 +Chromosome passenger complex 0.5433364398881543 0.1646985427728256 0.8691812640168999 1.0 1.0 2 Q53HL2 1 +Postsynaptic density intracellular component 0.4389182468138073 0.1616571278489282 0.871575867392218 1.0 1.0 4 P35222,Q9UQB8,P50570 3 +Hippocampal mossy fiber to ca3 synapse 0.4389182468138065 0.1616571278489262 0.8715758673922196 1.0 1.0 4 P47756,P63104,Q15375 3 +U6 snrnp 0.384639303482582 0.1612252142050067 0.8719160228302649 1.0 1.0 5 Q9UK45,Q9Y333,Q9Y4Z0,P62312 4 +Axon cytoplasm 0.3072451205828526 0.1603769171299313 0.8725841717120393 1.0 1.0 19 O60313,Q14168,O00203 3 +Non motile cilium 0.3142192340192027 0.1603205386786605 0.8726285806078642 1.0 1.0 15 P50148,P41208,Q15051,Q15154,Q15555,P35613,Q01968 7 +Vesicle membrane 0.4059339885617462 0.1572554030273663 0.8750435661067897 1.0 1.0 257 Q86Y82,O15498,Q07065,Q9NR31,P20020,P55011,Q4KMQ2,O15127,Q5T9L3,P61026,P07602,P24390,P04439,P30519,O15118,P84095,P62820,O43760,O60499,P42785,Q96PE3,Q9UNH7,Q14108,P20073,Q8N511,Q93050,O75396,Q9NZJ7,O00461,Q8IV08,Q9Y487,O00264,P13473,O14828,Q9UBB6,Q15363,Q9Y289,Q92542,Q8WTV0,P42892,Q5KU26,P27105,Q9NQX7,O43493,O76024,Q969Q5,Q96JJ7,P11279,Q15043,Q8TCT8,Q92543,P51790,O60831,Q08722,P35613,Q8NF37,Q9Y6Y8,Q96RL7,Q9UIQ6,O60749,Q04656,O15400,Q7Z3C6,Q96L92,P49755,Q15904,Q9NP58,Q7L0J3,P10253,O00203,Q9UH99,Q14728,O75787,Q9Y5X3,Q03519,O14656,Q5T9A4,Q03518,P10321,Q9BZG1 80 +Cell pole 0.5263714997069092 0.1553787037481541 0.8765227722066584 1.0 1.0 3 Q9BTU6 1 +Scf ubiquitin ligase complex 0.3620024796935999 0.1499860363134684 0.8807756320424922 1.0 1.0 7 Q13616 1 +Brca1 a complex 0.4338462440472263 0.1497063165218999 0.8809963244837138 1.0 1.0 4 P38398 1 +Rna polymerase ii transcription repressor complex 0.5200372786579631 0.1282862108794863 0.8979224770614174 1.0 1.0 2 Q9UHI6 1 +Wnt signalosome 0.5135135135134982 0.119333062596151 0.9050114904780052 1.0 1.0 2 P35222 1 +Photoreceptor outer segment 0.3530851593730444 0.1182911424500851 0.9058369754257036 1.0 1.0 7 P50148,P35613,Q01968 3 +Endosome 0.3831999118466553 0.1167022725895631 0.907095989318066 1.0 1.0 223 Q86Y82,O15498,Q8IY95,O14828,Q9UH99,Q92542,O75787,O14773,O15127,Q5T9L3,Q9Y5X3,Q9GZP9,Q96RL7,P61026,Q96PU5,P10644,P07602,Q9UIQ6,Q9BUN8,P04439,P42892,Q5VW38,P05067,Q13510,Q12768,O43493,P35670,O15118,O60749,Q04656,Q969Q5,Q9BRK5,P11279,P62820,Q9NX40,O15400,Q96A57,P10321,Q15043,Q8TCT8,Q96PE3,Q7Z3C6,Q9UNH7,Q14108,Q92543,P51790,Q96L92,O60831,Q567U6,Q93050,Q9BTU6,Q15904,Q9NZJ7,Q9NP58,O00461,Q8IV08,Q9Y487,P31751,P13473,O75955,P35613,P35232 62 +Caspase complex 0.3520617797957261 0.1147533920117017 0.9086405927062812 1.0 1.0 7 Q96S52,P04632,Q92643 3 +Myelin sheath 0.3243621481841763 0.1104025063573871 0.912090165496116 1.0 1.0 11 Q9NR77 1 +Mcm complex 0.3560457359709734 0.1015832519873267 0.9190874736499977 1.0 1.0 6 P33991 1 +Lsm2 8 complex 0.4109418713086801 0.1004242608635384 0.9200075097398304 1.0 1.0 4 P62312,Q9UK45,Q9Y4Z0 3 +Centriolar subdistal appendage 0.4869484151647142 0.090522187593623 0.9278722631820542 1.0 1.0 3 Q14203,O00139 2 +Pinosome 0.488661074867962 0.0899904767694366 0.9282947825600903 1.0 1.0 2 Q9UKG1 1 +Lamellipodium membrane 0.358519900497507 0.0881326579109077 0.9297712401024874 1.0 1.0 5 Q9UJX6,Q8WXH0,Q96AC1,Q9Y2A7 4 +Sperm annulus 0.4864864864864838 0.0877683427066481 0.9300607994961148 1.0 1.0 2 Q15019 1 +Schaffer collateral ca1 synapse 0.3001570724500719 0.0841997129939634 0.9328976463772168 1.0 1.0 15 Q16352,P07196 2 +Cd40 receptor complex 0.4694004349176724 0.0721182711085517 0.9425077858439416 1.0 1.0 2 O14920 1 +Centriolar satellite 0.2849645573484837 0.0647697778575304 0.9483573046821818 1.0 1.0 27 Q96R06,Q00013,Q9UPT5,Q9Y6A5,Q03518,Q15154,O75955,P54725,P11413,Q53EZ4,P33176 11 +Nuclear envelope lumen 0.3488313449807755 0.0641447992757805 0.948854930607144 1.0 1.0 5 P05067 1 +Extrinsic component of mitochondrial inner membrane 0.39073671122164 0.0634636475589352 0.9493973059115464 1.0 1.0 4 Q96BW9,Q8NC60,Q8NI60 3 +Chromatoid body 0.4392668530599429 0.0516096695021572 0.9588397144612156 1.0 1.0 2 Q08J23 1 +Multivesicular body membrane 0.3325526185003558 0.0514698178792761 0.9589511518054652 1.0 1.0 7 Q9Y3E7,Q9NZZ3,Q9UQN3,Q9NP58 4 +Ap 3 adaptor complex 0.4383348866107499 0.0511038920937747 0.9592427346050412 1.0 1.0 2 Q9P253 1 +Cytoplasmic microtubule 0.2872241626703962 0.0503885210253368 0.9598127836621652 1.0 1.0 20 Q9Y5M8 1 +Protein complex involved in cell adhesion 0.4311898105001531 0.0474558839007196 0.962149890241438 1.0 1.0 2 P05556 1 +Integrin complex 0.4311898105001531 0.0474558839007196 0.962149890241438 1.0 1.0 2 P05556 1 +Cell trailing edge 0.3368584758942388 0.046437392022565 0.9629616341218016 1.0 1.0 6 P15311,P35579,O75955,P26038,Q14254 5 +Mpp7 dlg1 lin7 complex 0.4484881512389532 0.0450040601686321 0.964104072688532 1.0 1.0 3 Q12959 1 +Escrt i complex 0.4187635911773765 0.0420176909004713 0.9664845952715608 1.0 1.0 2 Q9H9H4 1 +Dense core granule membrane 0.4162783473128301 0.0410580576834573 0.967249611507764 1.0 1.0 2 Q709C8 1 +Aryl hydrocarbon receptor complex 0.3988816402609524 0.0353992376318545 0.9717613926139927 1.0 1.0 2 O00170 1 +Chromocenter 0.3686664594342611 0.0300692040076953 0.9760118612617998 1.0 1.0 4 P83916,P45973,Q53HL2 3 +Cytoplasmic side of membrane 0.2756571592030648 0.0221767490845491 0.9823069645718427 1.0 1.0 45 P50148,P17900,P20020,Q8TCT8,Q8TCT9,P11413,P63218,Q9Y5X3,Q12959 9 +Collagen containing extracellular matrix 0.2779023701211452 0.0111859143667944 0.991075117749166 1.0 1.0 29 P07602 1 +Intrinsic component of postsynaptic density membrane 0.3924621915333213 0.0057758711134063 0.9953915472369652 1.0 1.0 3 P23634 1 diff --git a/msigdb_gocc/selections.json b/msigdb_gocc/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..a78828942c13c2d42f17b6e4fbce385e16c90e14 --- /dev/null +++ b/msigdb_gocc/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["90s preribosome", "9plus0 non motile cilium", "9plus2 motile cilium", "A band", "Acrosomal membrane", "Acrosomal vesicle", "Actin based cell projection", "Actin cytoskeleton", "Actin filament", "Actin filament bundle", "Actomyosin", "Adherens junction", "Aggresome", "Alpha dna polymerase primase complex", "Alveolar lamellar body", "Aminoacyl trna synthetase multienzyme complex", "Ampa glutamate receptor complex", "Amphisome", "Amphisome membrane", "Anaphase promoting complex", "Anchored component of membrane", "Anchored component of plasma membrane", "Anchored component of postsynaptic membrane", "Anchored component of synaptic membrane", "Anchored component of synaptic vesicle membrane", "Anchoring junction", "Annulate lamellae", "Ap 1 adaptor complex", "Ap 3 adaptor complex", "Ap type membrane coat adaptor complex", "Apical dendrite", "Apical junction complex", "Apical part of cell", "Apical plasma membrane", "Apicolateral plasma membrane", "Arp2 3 protein complex", "Aryl hydrocarbon receptor complex", "Aster", "Astrocyte end foot", "Astrocyte projection", "Atac complex", "Atp binding cassette abc transporter complex", "Atpase complex", "Atpase dependent transmembrane transport complex", "Autolysosome", "Autophagosome", "Autophagosome membrane", "Axolemma", "Axon", "Axon cytoplasm", "Axon hillock", "Axon initial segment", "Axonal growth cone", "Azurophil granule", "Azurophil granule lumen", "Azurophil granule membrane", "B wich complex", "Barr body", "Basal cortex", "Basal dendrite", "Basal part of cell", "Basement membrane", "Basolateral plasma membrane", "Bcl 2 family protein complex", "Beta catenin destruction complex", "Beta catenin tcf complex", "Bleb", "Bloc complex", "Blood microparticle", "Box c d rnp complex", "Box h aca rnp complex", "Box h aca snornp complex", "Box h aca telomerase rnp complex", "Brca1 a complex", "Brca1 c complex", "Brisc complex", "Brush border", "Brush border membrane", "Cajal body", "Calcineurin complex", "Calcium and calmodulin dependent protein kinase complex", "Calcium channel complex", "Calyx of held", "Camp dependent protein kinase complex", "Carboxy terminal domain protein kinase complex", "Caspase complex", "Catalytic complex", "Catalytic step 1 spliceosome", "Catalytic step 2 spliceosome", "Catenin complex", "Cation channel complex", "Cation transporting atpase complex", "Catsper complex", "Caveola", "Cbm complex", "Ccaat binding factor complex", "Ccr4 not complex", "Ccr4 not core complex", "Cd40 receptor complex", "Cd95 death inducing signaling complex", "Cdc73 paf1 complex", "Cell body", "Cell body membrane", "Cell cell contact zone", "Cell cell junction", "Cell cortex", "Cell cortex region", "Cell division site", "Cell leading edge", "Cell pole", "Cell projection membrane", "Cell substrate junction", "Cell surface", "Cell tip", "Cell trailing edge", "Centriolar satellite", "Centriolar subdistal appendage", "Centriole", "Centrosome", "Cerebellar mossy fiber", "Chaperone complex", "Chaperonin containing t complex", "Chitosome", "Chloride channel complex", "Cholinergic synapse", "Chromaffin granule", "Chromaffin granule membrane", "Chromatin", "Chromatin silencing complex", "Chromatoid body", "Chromocenter", "Chromosomal region", "Chromosome", "Chromosome centromeric core domain", "Chromosome centromeric region", "Chromosome passenger complex", "Chromosome telomeric region", "Chromosome telomeric repeat region", "Cia complex", "Ciliary basal body", "Ciliary base", "Ciliary membrane", "Ciliary plasm", "Ciliary rootlet", "Ciliary tip", "Ciliary transition zone", "Cilium", "Cis golgi network", "Cis golgi network membrane", "Clathrin adaptor complex", "Clathrin coat", "Clathrin coat of coated pit", "Clathrin coat of endocytic vesicle", "Clathrin coated endocytic vesicle", "Clathrin coated endocytic vesicle membrane", "Clathrin coated pit", "Clathrin coated vesicle", "Clathrin coated vesicle membrane", "Clathrin complex", "Clathrin sculpted gamma aminobutyric acid transport vesicle", "Clathrin sculpted vesicle", "Clathrin vesicle coat", "Cleavage furrow", "Cluster of actin based cell projections", "Coated vesicle", "Coated vesicle membrane", "Cohesin complex", "Collagen containing extracellular matrix", "Collagen trimer", "Commitment complex", "Compact myelin", "Condensed chromosome", "Condensed chromosome centromeric region", "Condensed nuclear chromosome", "Condensin complex", "Contractile fiber", "Contractile ring", "Cop9 signalosome", "Copi coated vesicle", "Copi coated vesicle membrane", "Copi vesicle coat", "Copii coated er to golgi transport vesicle", "Copii vesicle coat", "Core mediator complex", "Cornified envelope", "Cortical actin cytoskeleton", "Cortical cytoskeleton", "Cortical endoplasmic reticulum", "Cortical granule", "Costamere", "Crd mediated mrna stability complex", "Ctf18 rfc like complex", "Cul2 ring ubiquitin ligase complex", "Cul3 ring ubiquitin ligase complex", "Cul4 ring e3 ubiquitin ligase complex", "Cul4a ring e3 ubiquitin ligase complex", "Cul4b ring e3 ubiquitin ligase complex", "Cul5 ring ubiquitin ligase complex", "Cullin ring ubiquitin ligase complex", "Cuticular plate", "Cyclin a2 cdk2 complex", "Cyclin cdk positive transcription elongation factor complex", "Cyclin dependent protein kinase holoenzyme complex", "Cytochrome complex", "Cytolytic granule", "Cytoplasmic dynein complex", "Cytoplasmic exosome rnase complex", "Cytoplasmic microtubule", "Cytoplasmic region", "Cytoplasmic side of endoplasmic reticulum membrane", "Cytoplasmic side of endosome membrane", "Cytoplasmic side of lysosomal membrane", "Cytoplasmic side of membrane", "Cytoplasmic stress granule", "Cytoplasmic ubiquitin ligase complex", "Cytoskeleton of presynaptic active zone", "Cytosolic large ribosomal subunit", "Cytosolic region", "Cytosolic ribosome", "Cytosolic small ribosomal subunit", "Death inducing signaling complex", "Dendrite cytoplasm", "Dendrite membrane", "Dendrite terminus", "Dendritic growth cone", "Dendritic shaft", "Dendritic spine membrane", "Dendritic tree", "Dense body", "Dense core granule", "Dense core granule membrane", "Dentate gyrus mossy fiber", "Derlin 1 retrotranslocation complex", "Desmosome", "Dihydrolipoyl dehydrogenase complex", "Distal axon", "Dna packaging complex", "Dna polymerase complex", "Dna repair complex", "Dna replication factor c complex", "Dna replication preinitiation complex", "Dopaminergic synapse", "Dynactin complex", "Dynein axonemal particle", "Dynein complex", "Dystrophin associated glycoprotein complex", "Early endosome", "Early endosome lumen", "Early endosome membrane", "Early phagosome", "Ekc keops complex", "Elongator holoenzyme complex", "Elongin complex", "Emc complex", "Endocytic vesicle", "Endocytic vesicle lumen", "Endocytic vesicle membrane", "Endolysosome", "Endolysosome lumen", "Endolysosome membrane", "Endopeptidase complex", "Endoplasmic reticulum", "Endoplasmic reticulum chaperone complex", "Endoplasmic reticulum exit site", "Endoplasmic reticulum golgi intermediate compartment", "Endoplasmic reticulum golgi intermediate compartment membrane", "Endoplasmic reticulum lumen", "Endoplasmic reticulum palmitoyltransferase complex", "Endoplasmic reticulum plasma membrane contact site", "Endoplasmic reticulum protein containing complex", "Endoplasmic reticulum quality control compartment", "Endoplasmic reticulum tubular network", "Endoplasmic reticulum tubular network membrane", "Endoribonuclease complex", "Endosome", "Endosome lumen", "Endosome membrane", "Envelope", "Enzyme activator complex", "Epsilon dna polymerase complex", "Equatorial microtubule organizing center", "Er membrane insertion complex", "Er to golgi transport vesicle membrane", "Er ubiquitin ligase complex", "Esc e z complex", "Escrt complex", "Escrt i complex", "Escrt iii complex", "Euchromatin", "Eukaryotic translation initiation factor 2 complex", "Eukaryotic translation initiation factor 2b complex", "Eukaryotic translation initiation factor 3 complex", "Eukaryotic translation initiation factor 3 complex eif3m", "Eukaryotic translation initiation factor 4f complex", "Excitatory synapse", "Exocyst", "Exocytic vesicle", "Exon exon junction complex", "Exoribonuclease complex", "External encapsulating structure", "External side of apical plasma membrane", "External side of plasma membrane", "Extrinsic component of cytoplasmic side of plasma membrane", "Extrinsic component of endoplasmic reticulum membrane", "Extrinsic component of endosome membrane", "Extrinsic component of external side of plasma membrane", "Extrinsic component of membrane", "Extrinsic component of mitochondrial inner membrane", "Extrinsic component of organelle membrane", "Extrinsic component of plasma membrane", "Extrinsic component of postsynaptic membrane", "Extrinsic component of postsynaptic specialization membrane", "Extrinsic component of synaptic membrane", "F actin capping protein complex", "Fascia adherens", "Female germ cell nucleus", "Female pronucleus", "Fhf complex", "Fibrillar center", "Ficolin 1 rich granule", "Ficolin 1 rich granule lumen", "Ficolin 1 rich granule membrane", "Filamentous actin", "Filopodium", "Filopodium membrane", "Filopodium tip", "Filtration diaphragm", "Flemming body", "Flotillin complex", "Gaba ergic synapse", "Gamma secretase complex", "Gamma tubulin complex", "Gamma tubulin large complex", "Gap junction", "Gator2 complex", "Gemini of coiled bodies", "Germ cell nucleus", "Gid complex", "Glial cell projection", "Glutamatergic synapse", "Glycinergic synapse", "Glycogen granule", "Glycoprotein complex", "Golgi apparatus", "Golgi apparatus subcompartment", "Golgi associated vesicle", "Golgi associated vesicle membrane", "Golgi cis cisterna", "Golgi cisterna", "Golgi cisterna membrane", "Golgi lumen", "Golgi medial cisterna", "Golgi membrane", "Golgi stack", "Golgi transport complex", "Gpi anchor transamidase complex", "Granular component", "Growth cone membrane", "Gtpase complex", "Guanyl nucleotide exchange factor complex", "H3 histone acetyltransferase complex", "H4 h2a histone acetyltransferase complex", "H4 histone acetyltransferase complex", "Haus complex", "Hemidesmosome", "Hemoglobin complex", "Heterochromatin", "Hfe transferrin receptor complex", "High density lipoprotein particle", "Hippocampal mossy fiber", "Hippocampal mossy fiber to ca3 synapse", "Histone deacetylase complex", "Histone methyltransferase complex", "Histone pre mrna 3 end processing complex", "Hops complex", "Host cellular component", "Hrd1p ubiquitin ligase erad l complex", "Hulc complex", "I band", "Ikappab kinase complex", "Immunological synapse", "Inclusion body", "Inflammasome complex", "Inhibitory synapse", "Inner mitochondrial membrane protein complex", "Ino80 complex", "Ino80 type complex", "Insulin responsive compartment", "Integral component of cytoplasmic side of endoplasmic reticulum membrane", "Integral component of lysosomal membrane", "Integral component of presynaptic active zone membrane", "Integral component of synaptic vesicle membrane", "Integrator complex", "Integrin complex", "Intercalated disc", "Intercellular bridge", "Intercellular canaliculus", "Intermediate filament", "Intermediate filament cytoskeleton", "Intracellular protein containing complex", "Intraciliary transport particle", "Intraciliary transport particle b", "Intrinsic component of endoplasmic reticulum membrane", "Intrinsic component of golgi membrane", "Intrinsic component of mitochondrial inner membrane", "Intrinsic component of mitochondrial membrane", "Intrinsic component of mitochondrial outer membrane", "Intrinsic component of nuclear inner membrane", "Intrinsic component of organelle membrane", "Intrinsic component of peroxisomal membrane", "Intrinsic component of plasma membrane", "Intrinsic component of postsynaptic density membrane", "Intrinsic component of postsynaptic membrane", "Intrinsic component of postsynaptic specialization membrane", "Intrinsic component of presynaptic active zone membrane", "Intrinsic component of presynaptic membrane", "Intrinsic component of synaptic membrane", "Intrinsic component of synaptic vesicle membrane", "Intrinsic component of vacuolar membrane", "Ion channel complex", "Iron sulfur cluster assembly complex", "Iswi type complex", "Juxtaparanode region of axon", "Keratin filament", "Kinesin complex", "Kinetochore microtubule", "Lamellar body", "Lamellipodium", "Lamellipodium membrane", "Lamin filament", "Laminin complex", "Large ribosomal subunit", "Late endosome", "Late endosome membrane", "Lateral element", "Lateral part of cell", "Lateral plasma membrane", "Leading edge membrane", "Lipid droplet", "Lipopolysaccharide receptor complex", "Low density lipoprotein particle", "Lsm1 7 pat1 complex", "Lsm2 8 complex", "Lumenal side of endoplasmic reticulum membrane", "Lumenal side of membrane", "Lysosomal lumen", "M band", "Magnesium dependent protein serine threonine phosphatase complex", "Main axon", "Male germ cell nucleus", "Male pronucleus", "Manchette", "Mcm complex", "Mcrd mediated mrna stability complex", "Mediator complex", "Meiotic cohesin complex", "Meiotic spindle", "Membrane coat", "Membrane microdomain", "Membrane protein complex", "Messenger ribonucleoprotein complex", "Methylosome", "Methyltransferase complex", "Mhc class i peptide loading complex", "Mhc class i protein complex", "Mhc protein complex", "Mib complex", "Micos complex", "Microbody", "Microbody lumen", "Microbody membrane", "Microtubule", "Microtubule associated complex", "Microtubule bundle", "Microtubule cytoskeleton", "Microtubule end", "Microtubule minus end", "Microtubule organizing center", "Microtubule organizing center attachment site", "Microtubule plus end", "Microvillus", "Microvillus membrane", "Midbody", "Mismatch repair complex", "Mitochondria associated endoplasmic reticulum membrane", "Mitochondrial alpha ketoglutarate dehydrogenase complex", "Mitochondrial crista", "Mitochondrial envelope", "Mitochondrial intermembrane space protein transporter complex", "Mitochondrial large ribosomal subunit", "Mitochondrial matrix", "Mitochondrial permeability transition pore complex", "Mitochondrial protein containing complex", "Mitochondrial proton transporting atp synthase complex coupling factor f o", "Mitochondrial pyruvate dehydrogenase complex", "Mitochondrial small ribosomal subunit", "Mitochondrial tricarboxylic acid cycle enzyme complex", "Mitochondrion", "Mitotic cohesin complex", "Mitotic spindle", "Mitotic spindle astral microtubule", "Mitotic spindle microtubule", "Mitotic spindle midzone", "Mitotic spindle pole", "Mll1 2 complex", "Mll3 4 complex", "Mmxd complex", "Motile cilium", "Mpp7 dlg1 lin7 complex", "Mrna cleavage and polyadenylation specificity factor complex", "Mrna cleavage factor complex", "Mrna editing complex", "Multimeric ribonuclease p complex", "Multivesicular body", "Multivesicular body membrane", "Myelin sheath", "Myelin sheath abaxonal region", "Myelin sheath adaxonal region", "Myofilament", "Myosin complex", "Myosin filament", "Myosin ii complex", "N terminal protein acetyltransferase complex", "Nadh dehydrogenase complex", "Nascent polypeptide associated complex", "Nata complex", "Nbaf complex", "Neurofibrillary tangle", "Neurofilament", "Neuromuscular junction", "Neuron projection", "Neuron projection cytoplasm", "Neuron projection membrane", "Neuron projection terminus", "Neuron spine", "Neuron to neuron synapse", "Neuronal dense core vesicle", "Neuronal dense core vesicle membrane", "Neuronal ribonucleoprotein granule", "Neurotransmitter receptor complex", "Nlrp3 inflammasome complex", "Nls dependent protein nuclear import complex", "Node of ranvier", "Non motile cilium", "Nonhomologous end joining complex", "Npbaf complex", "Nsl complex", "Nuclear body", "Nuclear chromosome", "Nuclear cyclin dependent protein kinase holoenzyme complex", "Nuclear envelope", "Nuclear envelope lumen", "Nuclear exosome rnase complex", "Nuclear inclusion body", "Nuclear inner membrane", "Nuclear lamina", "Nuclear membrane", "Nuclear outer membrane", "Nuclear outer membrane endoplasmic reticulum membrane network", "Nuclear periphery", "Nuclear pore", "Nuclear pore central transport channel", "Nuclear pore nuclear basket", "Nuclear pore outer ring", "Nuclear protein containing complex", "Nuclear replication fork", "Nuclear rna export factor complex", "Nuclear speck", "Nuclear stress granule", "Nuclear ubiquitin ligase complex", "Nucleocytoplasmic transport complex", "Nucleoid", "Nucleolar ribonuclease p complex", "Nucleolus", "Nucleotide activated protein kinase complex", "Nucleotide excision repair complex", "Nurd complex", "Nurf complex", "Oligosaccharyltransferase complex", "Organellar ribosome", "Organelle envelope lumen", "Organelle inner membrane", "Organelle membrane contact site", "Organelle subcompartment", "Origin recognition complex", "Outer dense fiber", "Outer kinetochore", "Outer membrane", "Outer mitochondrial membrane protein complex", "Oxidoreductase complex", "Oxoglutarate dehydrogenase complex", "P body", "Palmitoyltransferase complex", "Pam complex tim23 associated import motor", "Parallel fiber to purkinje cell synapse", "Paranode region of axon", "Paraspeckles", "Pcg protein complex", "Peptidase complex", "Peptidase inhibitor complex", "Pericentric heterochromatin", "Pericentriolar material", "Periciliary membrane compartment", "Perikaryon", "Perinuclear endoplasmic reticulum", "Perinuclear region of cytoplasm", "Perinucleolar compartment", "Phagocytic cup", "Phagocytic vesicle", "Phagocytic vesicle lumen", "Phagocytic vesicle membrane", "Phagolysosome", "Phagophore assembly site", "Phagophore assembly site membrane", "Phosphatase complex", "Phosphatidylinositol 3 kinase complex", "Phosphatidylinositol 3 kinase complex class i", "Phosphatidylinositol 3 kinase complex class ia", "Phosphatidylinositol 3 kinase complex class iii", "Phosphorylase kinase complex", "Photoreceptor connecting cilium", "Photoreceptor inner segment", "Photoreceptor outer segment", "Photoreceptor ribbon synapse", "Pi body", "Picln sm protein complex", "Pigment granule", "Pinosome", "Pip body", "Plasma membrane protein complex", "Plasma membrane raft", "Plasma membrane region", "Plasma membrane signaling receptor complex", "Platelet alpha granule", "Platelet alpha granule lumen", "Platelet alpha granule membrane", "Platelet dense granule", "Platelet dense granule lumen", "Platelet dense granule membrane", "Platelet dense tubular network", "Platelet dense tubular network membrane", "Pml body", "Podosome", "Polar microtubule", "Pole plasm", "Polymeric cytoskeletal fiber", "Polysomal ribosome", "Polysome", "Pore complex", "Post mrna release spliceosomal complex", "Postsynapse", "Postsynaptic cytoskeleton", "Postsynaptic cytosol", "Postsynaptic density intracellular component", "Postsynaptic density membrane", "Postsynaptic endocytic zone", "Postsynaptic endosome", "Postsynaptic membrane", "Postsynaptic recycling endosome", "Postsynaptic specialization intracellular component", "Postsynaptic specialization membrane", "Potassium channel complex", "Prc1 complex", "Pre snornp complex", "Precatalytic spliceosome", "Prefoldin complex", "Preribosome", "Preribosome large subunit precursor", "Preribosome small subunit precursor", "Prespliceosome", "Presynapse", "Presynaptic active zone", "Presynaptic active zone cytoplasmic component", "Presynaptic active zone membrane", "Presynaptic cytoskeleton", "Presynaptic cytosol", "Presynaptic endocytic zone", "Presynaptic membrane", "Pronucleus", "Protease inhibitor complex", "Proteasome accessory complex", "Proteasome complex", "Proteasome core complex", "Proteasome core complex alpha subunit complex", "Proteasome core complex beta subunit complex", "Proteasome regulatory particle", "Proteasome regulatory particle base subcomplex", "Proteasome regulatory particle lid subcomplex", "Protein acetyltransferase complex", "Protein complex involved in cell adhesion", "Protein dna complex", "Protein kinase complex", "Protein lipid complex", "Protein phosphatase 4 complex", "Protein phosphatase type 1 complex", "Protein phosphatase type 2a complex", "Proton transporting atp synthase complex", "Proton transporting atp synthase complex catalytic core f 1", "Proton transporting atp synthase complex coupling factor f o", "Proton transporting two sector atpase complex", "Proton transporting two sector atpase complex catalytic domain", "Proton transporting two sector atpase complex proton transporting domain", "Proton transporting v type atpase complex", "Proton transporting v type atpase v0 domain", "Proton transporting v type atpase v1 domain", "Proximal dendrite", "Prp19 complex", "Pseudopodium", "Ptw pp1 phosphatase complex", "Pwp2p containing subcomplex of 90s preribosome", "R2tp complex", "Ragulator complex", "Rdna heterochromatin", "Receptor complex", "Recycling endosome", "Recycling endosome membrane", "Replication fork", "Replisome", "Respirasome", "Respiratory chain complex iii", "Respiratory chain complex iv", "Retromer complex", "Ribbon synapse", "Ribonuclease mrp complex", "Ribonuclease p complex", "Ribonucleoprotein complex", "Ribonucleoprotein granule", "Ribose phosphate diphosphokinase complex", "Ribosomal subunit", "Ribosome", "Ripoptosome", "Risc loading complex", "Rna cap binding complex", "Rna polymerase complex", "Rna polymerase i complex", "Rna polymerase ii core complex", "Rna polymerase ii holoenzyme", "Rna polymerase ii transcription regulator complex", "Rna polymerase ii transcription repressor complex", "Rna polymerase iii complex", "Rna polymerase iii transcription regulator complex", "Rnai effector complex", "Rough endoplasmic reticulum", "Rough endoplasmic reticulum membrane", "Rpap3 r2tp prefoldin like complex", "Ruffle", "Ruffle membrane", "Saga complex", "Saga type complex", "Sarcolemma", "Sarcoplasm", "Sarcoplasmic reticulum lumen", "Sarcoplasmic reticulum membrane", "Scar complex", "Scf ubiquitin ligase complex", "Schaffer collateral ca1 synapse", "Sec61 translocon complex", "Secondary lysosome", "Secretory granule", "Secretory granule membrane", "Secretory vesicle", "Seh1 associated complex", "Semaphorin receptor complex", "Septin cytoskeleton", "Serine protease inhibitor complex", "Set1c compass complex", "Sex chromatin", "Sex chromosome", "Shelterin complex", "Side of membrane", "Signal peptidase complex", "Signal recognition particle", "Sin3 complex", "Sin3 type complex", "Site of dna damage", "Site of double strand break", "Site of polarized growth", "Sm like protein family complex", "Small ribosomal subunit", "Small subunit processome", "Smc5 smc6 complex", "Smn complex", "Smn sm protein complex", "Smooth endoplasmic reticulum", "Smooth endoplasmic reticulum membrane", "Snare complex", "Sno s rna containing ribonucleoprotein complex", "Sodium potassium exchanging atpase complex", "Somatodendritic compartment", "Sorting endosome", "Spanning component of membrane", "Specific granule", "Specific granule lumen", "Specific granule membrane", "Spectrin", "Spectrin associated cytoskeleton", "Sperm annulus", "Sperm connecting piece", "Sperm fibrous sheath", "Sperm head", "Sperm head plasma membrane", "Sperm midpiece", "Sperm plasma membrane", "Sperm principal piece", "Spermatoproteasome complex", "Spindle", "Spindle microtubule", "Spindle midzone", "Spindle pole", "Spindle pole centrosome", "Spliceosomal complex", "Spliceosomal snrnp complex", "Spliceosomal tri snrnp complex", "Stereocilium bundle", "Stereocilium membrane", "Stereocilium tip", "Striated muscle thin filament", "Sumo ligase complex", "Supramolecular complex", "Supramolecular polymer", "Swi snf complex", "Swr1 complex", "Synapse", "Synaptic cleft", "Synaptic membrane", "Synaptic vesicle membrane", "Synaptonemal structure", "T tubule", "Telomerase holoenzyme complex", "Terminal bouton", "Tertiary granule", "Tertiary granule lumen", "Tertiary granule membrane", "Tetraspanin enriched microdomain", "Tho complex", "Tight junction", "Tim22 mitochondrial import inner membrane insertion complex", "Tim23 mitochondrial import inner membrane translocase complex", "Tor complex", "Torc1 complex", "Trans golgi network", "Trans golgi network membrane", "Trans golgi network transport vesicle", "Trans golgi network transport vesicle membrane", "Transcription elongation factor complex", "Transcription export complex", "Transcription export complex 2", "Transcription factor tfiid complex", "Transcription factor tfiih holo complex", "Transcription factor tfiiic complex", "Transcription factor tftc complex", "Transcription preinitiation complex", "Transcription regulator complex", "Transcription repressor complex", "Transferase complex", "Transferase complex transferring phosphorus containing groups", "Translation preinitiation complex", "Translocon complex", "Transport vesicle", "Transport vesicle membrane", "Transporter complex", "Trapp complex", "Tricarboxylic acid cycle enzyme complex", "Triglyceride rich plasma lipoprotein particle", "Trna methyltransferase complex", "Trna splicing ligase complex", "Tubular endosome", "U1 snrnp", "U12 type spliceosomal complex", "U2 snrnp", "U2 type catalytic step 2 spliceosome", "U2 type spliceosomal complex", "U2af complex", "U4 snrnp", "U5 snrnp", "U6 snrnp", "U7 snrnp", "Ubiquinone biosynthesis complex", "Ubiquitin conjugating enzyme complex", "Ubiquitin ligase complex", "Unconventional myosin complex", "Uniplex complex", "Vacuolar lumen", "Vacuolar membrane", "Vacuolar proton transporting v type atpase v0 domain", "Vacuole", "Varicosity", "Vcp npl4 ufd1 aaa atpase complex", "Vesicle coat", "Vesicle lumen", "Vesicle membrane", "Vesicle tethering complex", "Voltage gated calcium channel complex", "Wash complex", "Weibel palade body", "Wnt signalosome", "X chromosome", "Xy body", "Zona pellucida receptor complex", "Zonula adherens", "Zymogen granule", "Zymogen granule membrane"], "available_proteins": ["AAAS", "AAR2", "AARS", "AARS2", "AASS", "AATF", "ABCB1", "ABCB10", "ABCB6", "ABCB7", "ABCB8", "ABCC4", "ABCD3", "ABCE1", "ABCF1", "ABHD10", "ABHD12", "ABHD14B", "ABHD6", "ABRAXAS2", "ACAA1", "ACAA2", "ACACA", "ACACB", "ACAD11", "ACAD9", "ACADM", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACBD5", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT8", "ACOT9", "ACOX1", "ACOX3", "ACP1", "ACP2", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACSL6", "ACTL6A", "ACTN1", "ACTN4", "ACTR1A", "ACTR1B", "ACTR2", "ACTR3", "ACTR8", "ADA", "ADAR", "ADD1", "ADD3", "ADH5", "ADNP", "ADPGK", "ADRM1", "ADSS", "AFDN", "AFG3L2", "AGK", "AGL", "AGPAT1", "AGPAT5", "AGPS", "AHCTF1", "AHCY", "AHCYL1", "AHNAK", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AK3", "AK4", "AK6", "AKAP1", "AKAP10", "AKAP8", "AKAP8L", "AKAP9", "AKR1A1", "AKR7A2", "AKT2", "ALDH18A1", "ALDH1A2", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDOA", "ALDOC", "ALG1", "ALG11", "ALG5", "ALKBH5", "ALYREF", "AMOT", "ANAPC1", "ANAPC16", "ANAPC2", "ANAPC4", "ANAPC5", "ANAPC7", "ANGEL1", "ANK3", "ANKFY1", "ANKLE2", "ANKRD17", "ANLN", "ANO6", "ANP32A", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA4", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP1M1", "AP1S1", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "APEH", "APEX1", "API5", "APMAP", "APOO", "APOOL", "APP", "APPL1", "APRT", "AQR", "ARCN1", "ARF4", "ARF6", "ARFGAP1", "ARFIP1", "ARFIP2", "ARG2", "ARGLU1", "ARHGAP17", "ARHGDIA", "ARHGEF2", "ARID1A", "ARID2", "ARIH2", "ARL1", "ARL2", "ARL3", "ARL6IP1", "ARL6IP5", "ARL8A", "ARMC1", "ARMC10", "ARMCX3", "ARPC1A", "ARPC2", "ARPC3", "ARPC4", "ARVCF", "ASAH1", "ASCC2", "ASCC3", "ASH2L", "ASNA1", "ASPH", "ASPSCR1", "ATAD1", "ATAD3A", "ATAD3B", "ATAD5", "ATG3", "ATG9A", "ATL2", "ATP13A1", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP2B4", "ATP2C1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6AP1", "ATP6AP2", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1D", "ATP6V1E1", "ATP6V1H", "ATP7A", "ATP7B", "ATPAF1", "ATPIF1", "ATRIP", "ATXN10", "ATXN2L", "AUP1", "AURKA", "B3GALT6", "B4GAT1", "BABAM1", "BABAM2", "BAG2", "BAG3", "BAG5", "BAG6", "BAIAP2", "BANF1", "BAP18", "BARD1", "BASP1", "BAZ1A", "BAZ1B", "BAZ2A", "BCAP31", "BCAS2", "BCAS3", "BCCIP", "BCKDK", "BCLAF1", "BCR", "BCS1L", "BICD2", "BIRC6", "BLM", "BMS1", "BNIP1", "BOLA2*", "BOP1", "BPTF", "BRAP", "BRCA1", "BRD1", "BRD2", "BRD4", "BRIX1", "BRMS1L", "BSG", "BTF3", "BUB1B", "BUB3", "BUD23", "BUD31", "BYSL", "C12orf73", "C17orf75", "C19orf70", "C1QBP", "C1orf35", "C2CD5", "C2orf49", "CAB39", "CACYBP", "CAD", "CALD1", "CALR", "CALU", "CAMK2G", "CAMSAP3", "CAND1", "CANT1", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPNS1", "CAPRIN1", "CAPZA1", "CAPZB", "CARHSP1", "CASK", "CAST", "CBX1", "CBX2", "CBX3", "CBX5", "CBX8", "CC2D1A", "CCAR1", "CCAR2", "CCDC134", "CCDC22", "CCDC47", "CCDC86", "CCDC93", "CCNB1", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2AP", "CD2BP2", "CD3EAP", "CD47", "CDC16", "CDC23", "CDC27", "CDC37", "CDC42", "CDC5L", "CDC73", "CDCA2", "CDCA5", "CDCA7L", "CDCA8", "CDH2", "CDIPT", "CDK1", "CDK12", "CDK2", "CDK4", "CDK5", "CDK5RAP1", "CDK5RAP3", "CDK6", "CDK9", "CDKAL1", "CDKN2A", "CDKN2AIP", "CDS2", "CEBPZ", "CELF1", "CELF2", "CENPB", "CENPI", "CENPP", "CENPV", "CEP170", "CEP44", "CEP55", "CEP72", "CERS2", "CERS5", "CETN2", "CFAP20", "CFL1", "CFL2", "CHAF1A", "CHAF1B", "CHAMP1", "CHCHD3", "CHD1", "CHD4", "CHD8", "CHDH", "CHERP", "CHID1", "CHMP2B", "CHMP3", "CHMP4B", "CHMP5", "CHMP7", "CHORDC1", "CHRAC1", "CHST14", "CHTF18", "CHTOP", "CIAPIN1", "CIB1", "CIRBP", "CISD2", "CIT", "CKAP2", "CKAP4", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLASP2", "CLCC1", "CLCN3", "CLCN7", "CLGN", "CLIC1", "CLINT1", "CLN5", "CLNS1A", "CLPB", "CLPP", "CLPTM1", "CLPX", "CLSPN", "CLTA", "CLTB", "CLTC", "CMPK1", "CNN2", "CNN3", "CNNM4", "CNOT1", "CNOT4", "CNOT9", "CNP", "COA3", "COA7", "COG2", "COG3", "COG4", "COG5", "COG6", "COG7", "COIL", "COL4A3BP", "COLEC12", "COLGALT1", "COMT", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS8", "COPZ1", "COQ8A", "COQ9", "CORO1B", "CORO1C", "CORO7", "COTL1", "COX15", "COX18", "COX2", "COX4I1", "COX5A", "COX5B", "COX6C", "COX7A2", "COX7A2L", "CPNE1", "CPNE3", "CPOX", "CPSF1", "CPSF2", "CPSF3", "CPSF6", "CPSF7", "CPT1A", "CPT2", "CRK", "CRKL", "CRNKL1", "CRTAP", "CS", "CSDE1", "CSE1L", "CSGALNACT2", "CSK", "CSNK1A1", "CSNK2A1", "CSNK2A2", "CSNK2B", "CSRP2", "CSTB", "CSTF1", "CSTF2", "CTBP1", "CTBP2", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTR9", "CTSA", "CTSC", "CTTN", "CTTNBP2NL", "CUL1", "CUL2", "CUL3", "CUL4A", "CUL4B", "CUL5", "CWC15", "CWC22", "CWF19L1", "CXADR", "CXorf56", "CXorf57", "CYB5B", "CYB5R1", "CYB5R3", "CYC1", "CYFIP1", "CYFIP2", "CYP51A1", "DAGLB", "DAP3", "DARS", "DARS2", "DAZAP1", "DBN1", "DBNL", "DBT", "DCAF1", "DCAF13", "DCAF7", "DCAF8", "DCP1B", "DCPS", "DCTN1", "DCTN2", "DCTN3", "DCTN4", "DCTPP1", "DCUN1D1", "DCUN1D5", "DCXR", "DDB1", "DDI2", "DDOST", "DDRGK1", "DDX1", "DDX17", "DDX18", "DDX20", "DDX21", "DDX23", "DDX24", "DDX27", "DDX28", "DDX39A", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX5", "DDX50", "DDX51", "DDX52", "DDX54", "DDX56", "DDX6", "DEK", "DENND6A", "DERL1", "DERL2", "DFFA", "DHCR24", "DHCR7", "DHFR", "DHRS1", "DHRS13", "DHRS7", "DHRS7B", "DHTKD1", "DHX15", "DHX16", "DHX29", "DHX30", "DHX36", "DHX37", "DHX38", "DHX8", "DHX9", "DIAPH1", "DIAPH2", "DICER1", "DIDO1", "DIEXF", "DIMT1", "DIS3", "DKC1", "DLAT", "DLD", "DLG1", "DLGAP5", "DLST", "DMAP1", "DNA2", "DNAAF5", "DNAJA1", "DNAJA3", "DNAJB1", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC13", "DNAJC2", "DNAJC21", "DNAJC3", "DNAJC8", "DNAJC9", "DNM1L", "DNM2", "DNMT1", "DNTTIP2", "DOCK7", "DOLPP1", "DPF2", "DPM1", "DPP9", "DPY30", "DPYSL2", "DPYSL3", "DPYSL5", "DRG1", "DSC3", "DSCR3", "DSG2", "DSP", "DST", "DSTN", "DTX3L", "DTYMK", "DUS2", "DUSP3", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNC2H1", "DYNLL1", "DYNLL2", "EARS2", "EBNA1BP2", "EBP", "ECE1", "ECH1", "ECHS1", "ECI1", "ECI2", "ECSIT", "EDC3", "EDC4", "EDF1", "EEA1", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EFL1", "EFTUD2", "EHBP1", "EHD1", "EHD4", "EI24", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2D", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E", "EIF4E2", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5A", "EIF6", "ELAC2", "ELAVL1", "ELL", "ELOA", "ELOB", "ELP1", "ELP2", "ELP3", "ELP4", "EMC1", "EMC2", "EMC7", "EMD", "EMG1", "EML4", "ENAH", "ENO1", "ENO2", "ENY2", "EP400", "EPB41", "EPB41L2", "EPB41L3", "EPB41L5", "EPDR1", "EPHA7", "EPHX1", "EPHX2", "EPN1", "EPPK1", "EPRS", "EPS15L1", "ERAL1", "ERAP1", "ERAP2", "ERBIN", "ERC1", "ERCC2", "ERCC3", "ERCC6L", "ERG28", "ERGIC1", "ERGIC3", "ERH", "ERLIN1", "ERLIN2", "ERMP1", "ERO1A", "ERO1B", "ERP29", "ESD", "ESF1", "ESYT1", "ESYT2", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXD2", "EXO1", "EXOC2", "EXOC3", "EXOC5", "EXOC6", "EXOC7", "EXOC8", "EXOSC1", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC8", "EXOSC9", "EZR", "F11R", "FADS2", "FAF1", "FAF2", "FAHD1", "FAM129B", "FAM162A", "FAM208A", "FAM49B", "FAM98A", "FAM98B", "FANCD2", "FANCI", "FAR1", "FARP1", "FARSA", "FARSB", "FASN", "FASTKD5", "FBL", "FDFT1", "FDXR", "FECH", "FEN1", "FERMT2", "FGFR1OP", "FH", "FHL1", "FHOD1", "FIP1L1", "FIS1", "FKBP10", "FKBP14", "FKBP2", "FKBP4", "FKBP7", "FKBP8", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FMR1", "FNBP4", "FNDC3A", "FNTA", "FNTB", "FOCAD", "FOXC1", "FOXK1", "FOXRED1", "FRYL", "FSCN1", "FSD1", "FTO", "FTSJ3", "FUCA1", "FUCA2", "FUNDC2", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GADD45GIP1", "GAK", "GALNS", "GALNT1", "GALNT2", "GALNT4", "GALNT7", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GATAD2A", "GATAD2B", "GATB", "GBA", "GBF1", "GCAT", "GCDH", "GCFC2", "GCLC", "GCN1", "GDAP1", "GDI1", "GDI2", "GDPD1", "GEMIN4", "GEMIN5", "GEMIN8", "GET4", "GFM1", "GGA1", "GGCX", "GGH", "GHDC", "GHITM", "GID4", "GIGYF2", "GINS2", "GINS3", "GINS4", "GLA", "GLB1", "GLCE", "GLDC", "GLE1", "GLG1", "GLMN", "GLOD4", "GLRX3", "GLRX5", "GLS", "GLUD1", "GLYR1", "GM2A", "GNA13", "GNAI1", "GNAI2", "GNAI3", "GNAQ", "GNG12", "GNG5", "GNL2", "GNL3", "GNL3L", "GNPAT", "GNPNAT1", "GNS", "GOLGA2", "GOLGA3", "GOLGA5", "GOLGB1", "GOLIM4", "GOLT1B", "GORASP2", "GOSR1", "GOT2", "GPAA1", "GPAM", "GPAT4", "GPATCH4", "GPD1L", "GPD2", "GPHN", "GPI", "GPKOW", "GPR107", "GPR108", "GPR89B", "GPS1", "GPT2", "GPX8", "GRB2", "GRHPR", "GRPEL1", "GRSF1", "GRWD1", "GSK3B", "GSR", "GSTK1", "GSTM3", "GSTZ1", "GTF2E1", "GTF2E2", "GTF2F1", "GTF2H1", "GTF2H4", "GTF3C1", "GTF3C2", "GTF3C3", "GTF3C4", "GTF3C5", "GTPBP1", "GTPBP10", "GTPBP3", "GTPBP4", "GUF1", "GYG1", "GYS1", "H1F0", "H1FX", "H2AFY", "H2AFY2", "H4C1*", "HACD3", "HACL1", "HADH", "HADHA", "HADHB", "HARS2", "HAT1", "HAUS1", "HAUS3", "HAUS4", "HAUS5", "HAUS6", "HAX1", "HCCS", "HCFC1", "HDAC1", "HDAC2", "HDGF", "HDHD5", "HDLBP", "HEATR1", "HECTD3", "HELLS", "HEXA", "HEXB", "HGS", "HIBADH", "HIBCH", "HINT2", "HIRA", "HIRIP3", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLTF", "HM13", "HMCES", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMGCL", "HMGCR", "HMGN2", "HMMR", "HMOX1", "HMOX2", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPM", "HNRNPR", "HNRNPU", "HOOK2", "HOOK3", "HP1BP3", "HPS6", "HS2ST1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSD17B7", "HSDL1", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA13", "HSPA14", "HSPA1B", "HSPA2", "HSPA4", "HSPA8", "HSPA9", "HSPD1", "HSPE1", "HSPH1", "HTATSF1", "HTT", "HUWE1", "HYOU1", "IARS", "IARS2", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDH3G", "IDI1", "IFIT5", "IFT27", "IFT81", "IGF2BP1", "IGF2BP3", "IGF2R", "IK", "IKBIP", "IKBKB", "ILF2", "ILF3", "ILK", "ILVBL", "IMMT", "IMP3", "IMP4", "IMPAD1", "IMPDH1", "IMPDH2", "INA", "INF2", "INPP4A", "INPPL1", "INTS1", "INTS11", "INTS14", "INTS2", "INTS3", "INTS4", "INTS7", "INTS8", "INTS9", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQCB1", "IQGAP1", "IQGAP3", "ISG20L2", "ISOC1", "IST1", "ISY1", "ITCH", "ITGB1", "ITM2C", "ITPK1", "ITSN2", "IVD", "JAGN1", "JMJD6", "JUP", "KARS", "KAT7", "KCTD12", "KDELC2", "KDELR1", "KDM1A", "KDM1B", "KDM3B", "KDM5A", "KDSR", "KHDRBS1", "KIAA0319L", "KIAA0368", "KIAA0391", "KIAA1468", "KIDINS220", "KIF11", "KIF14", "KIF18A", "KIF18B", "KIF1A", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF3A", "KIF4A", "KIF5B", "KIFBP", "KIN", "KLC1", "KLC4", "KMT2A", "KNOP1", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNA6", "KPNB1", "KRI1", "KRR1", "KTN1", "KYAT3", "L2HGDH", "LACTB", "LAMB1", "LAMC1", "LAMP1", "LAMP2", "LAMTOR1", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LAS1L", "LASP1", "LBR", "LCLAT1", "LDAH", "LDHA", "LDHB", "LDLR", "LEMD3", "LETM1", "LGALS3", "LGALS3BP", "LGMN", "LIG1", "LIG3", "LIMA1", "LIN9", "LIPA", "LLGL1", "LLPH", "LMAN2", "LMAN2L", "LMF2", "LMNA", "LMNB1", "LMNB2", "LNPEP", "LNPK", "LONP1", "LPCAT1", "LPGAT1", "LRBA", "LRP1", "LRPAP1", "LRPPRC", "LRRC59", "LRRC8C", "LRWD1", "LSM2", "LSM4", "LSM6", "LSM7", "LSS", "LTA4H", "LTV1", "LUC7L", "LUC7L2", "LUC7L3", "LYAR", "LYN", "LYPLA1", "M6PR", "MACF1", "MAEA", "MAGED2", "MAGT1", "MAIP1", "MAK16", "MALT1", "MAN2A1", "MAN2B1", "MANF", "MAP1A", "MAP1B", "MAP1S", "MAP4", "MAP7D1", "MAPK1", "MAPK14", "MAPRE1", "MAPRE2", "MARC1", "MARCH5", "MARS", "MARS2", "MAT2A", "MAT2B", "MATR3", "MAU2", "MAVS", "MBD3", "MBOAT7", "MCAM", "MCCC1", "MCCC2", "MCL1", "MCM10", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCU", "MCUB", "MCUR1", "MDC1", "MDH1", "MDH2", "MDN1", "ME1", "ME2", "MECP2", "MED14", "MED17", "MED22", "MED23", "MED24", "MED4", "MEPCE", "MESD", "METTL13", "METTL3", "METTL7B", "METTL9", "MFN1", "MFN2", "MFSD10", "MGST2", "MGST3", "MIA2", "MIA3", "MICU1", "MIEF1", "MIF", "MIGA1", "MINDY3", "MINPP1", "MIPEP", "MKI67", "MKLN1", "MLEC", "MMAB", "MMS19", "MOGS", "MON2", "MORC2", "MORF4L1", "MORF4L2", "MOSPD2", "MOV10", "MPC2", "MPG", "MPHOSPH10", "MPHOSPH6", "MPHOSPH8", "MPP1", "MPP2", "MPP6", "MPP7", "MPRIP", "MPST", "MPV17", "MPV17L2", "MRC2", "MRE11", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL14", "MRPL15", "MRPL17", "MRPL19", "MRPL2", "MRPL20", "MRPL21", "MRPL22", "MRPL24", "MRPL28", "MRPL3", "MRPL37", "MRPL38", "MRPL39", "MRPL40", "MRPL41", "MRPL43", "MRPL44", "MRPL45", "MRPL46", "MRPL47", "MRPL48", "MRPL49", "MRPL50", "MRPL53", "MRPL58", "MRPL9", "MRPS11", "MRPS16", "MRPS18A", "MRPS22", "MRPS23", "MRPS25", "MRPS27", "MRPS28", "MRPS30", "MRPS31", "MRPS33", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRPS9", "MRRF", "MRTO4", "MSH2", "MSH3", "MSH6", "MSI1", "MSI2", "MSMO1", "MSN", "MSTO1", "MTA1", "MTA2", "MTBP", "MTCH1", "MTCH2", "MTDH", "MTHFD1", "MTHFD1L", "MTHFD2", "MTHFS", "MTMR14", "MTMR2", "MTMR6", "MTO1", "MTOR", "MTPAP", "MTPN", "MTX1", "MTX2", "MTX3", "MUL1", "MUT", "MVD", "MYBBP1A", "MYCBP", "MYCBP2", "MYDGF", "MYEF2", "MYG1", "MYH10", "MYH14", "MYH9", "MYL6", "MYO18A", "MYO1B", "MYO1C", "MYO1D", "MYO6", "NAA10", "NAA15", "NAA25", "NAA35", "NAA40", "NAA50", "NAF1", "NAGLU", "NAMPT", "NAP1L1", "NAP1L4", "NAPA", "NAPG", "NASP", "NAT10", "NAXE", "NBAS", "NBN", "NCAPD2", "NCAPD3", "NCAPG", "NCAPG2", "NCAPH", "NCBP1", "NCBP3", "NCDN", "NCEH1", "NCKAP1", "NCKIPSD", "NCL", "NCLN", "NCOA5", "NCOR1", "NCSTN", "ND1", "NDC1", "NDC80", "NDUFA10", "NDUFA11", "NDUFA13", "NDUFA4", "NDUFA5", "NDUFA7", "NDUFA8", "NDUFA9", "NDUFAF2", "NDUFAF3", "NDUFAF4", "NDUFAF7", "NDUFB10", "NDUFB3", "NDUFB4", "NDUFB5", "NDUFB6", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS6", "NDUFS7", "NDUFS8", "NDUFV1", "NDUFV2", "NECAP2", "NEDD1", "NEDD4L", "NEFL", "NEFM", "NEK9", "NELFA", "NELFB", "NELFCD", "NELFE", "NENF", "NES", "NF1", "NFS1", "NFU1", "NFXL1", "NHLRC2", "NHP2", "NIFK", "NIP7", "NIPBL", "NIPSNAP1", "NIPSNAP2", "NISCH", "NIT2", "NKRF", "NLE1", "NLN", "NLRX1", "NME1", "NME2", "NMT1", "NNT", "NOA1", "NOB1", "NOC2L", "NOC3L", "NOC4L", "NOL10", "NOL11", "NOL6", "NOL7", "NOL8", "NOL9", "NOLC1", "NOM1", "NONO", "NOP14", "NOP16", "NOP2", "NOP53", "NOP56", "NOP58", "NOP9", "NOSIP", "NOTCH2", "NPC1", "NPC2", "NPLOC4", "NPM1", "NRBP1", "NRDC", "NRDE2", "NRP1", "NSA2", "NSD1", "NSD2", "NSD3", "NSDHL", "NSF", "NSMCE2", "NSUN2", "NT5C3A", "NTHL1", "NUB1", "NUBP2", "NUBPL", "NUCB1", "NUCB2", "NUCKS1", "NUDC", "NUDCD2", "NUDCD3", "NUDT1", "NUDT21", "NUF2", "NUFIP2", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP160", "NUP188", "NUP205", "NUP210", "NUP214", "NUP35", "NUP37", "NUP43", "NUP50", "NUP54", "NUP58", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NUPL2", "NUSAP1", "NUTF2", "NVL", "NXF1", "OARD1", "OAT", "OCIAD1", "OCLN", "OCRL", "OGDH", "OGT", "OLA1", "OPA1", "OPA3", "ORC2", "ORC3", "ORC5", "OSBP", "OSBPL11", "OSBPL1A", "OSBPL6", "OSBPL8", "OSBPL9", "OSGEP", "OSTF1", "OXA1L", "OXSR1", "P3H1", "P3H4", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PAF1", "PAFAH1B1", "PAFAH1B2", "PAFAH1B3", "PAK1IP1", "PAK2", "PALLD", "PARD3", "PARG", "PARK7", "PARN", "PARP1", "PARP2", "PATL1", "PBRM1", "PC", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCM1", "PCNA", "PCYOX1", "PDAP1", "PDCD11", "PDCD6", "PDCD6IP", "PDCL3", "PDE12", "PDHA1", "PDHB", "PDHX", "PDIA3", "PDIA4", "PDIA6", "PDK1", "PDK3", "PDLIM1", "PDLIM5", "PDP1", "PDS5A", "PDS5B", "PDSS2", "PDXDC1", "PDZD8", "PECR", "PEF1", "PELP1", "PES1", "PEX11B", "PEX14", "PEX19", "PEX3", "PFDN2", "PFDN4", "PFDN5", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGK1", "PGM1", "PGM2", "PGRMC1", "PGRMC2", "PHB", "PHB2", "PHF10", "PHF2", "PHF5A", "PHF6", "PHIP", "PHKA1", "PHKB", "PI4K2A", "PI4KA", "PI4KB", "PICALM", "PIGG", "PIGK", "PIGS", "PIGT", "PIGU", "PIH1D1", "PIK3C2A", "PIK3R2", "PIK3R4", "PIN1", "PIN4", "PINX1", "PIP4K2C", "PISD", "PITPNB", "PITRM1", "PKM", "PKMYT1", "PKN1", "PKN2", "PLA2G15", "PLAA", "PLBD2", "PLCG1", "PLD3", "PLD6", "PLEC", "PLEKHA5", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLRG1", "PLS3", "PLXNB2", "PMPCA", "PMPCB", "PMVK", "PNKP", "PNN", "PNO1", "PNP", "PNPLA6", "PNPLA8", "PNPT1", "POFUT1", "POGZ", "POLA1", "POLA2", "POLD1", "POLD2", "POLDIP2", "POLDIP3", "POLE", "POLE2", "POLG", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2A", "POLR2B", "POLR2C", "POLR2D", "POLR2E", "POLR2G", "POLR2L", "POLR3A", "POLR3B", "POLR3C", "POLRMT", "PON2", "POP1", "POP4", "POR", "PPA2", "PPAN", "PPCDC", "PPFIA1", "PPHLN1", "PPIB", "PPID", "PPIE", "PPIF", "PPIG", "PPIH", "PPOX", "PPP1CA", "PPP1CB", "PPP1R10", "PPP1R7", "PPP1R8", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP2R5E", "PPP3CA", "PPP4R1", "PPP4R3A", "PPP5C", "PPP6C", "PPT1", "PPWD1", "PQBP1", "PRAF2", "PRC1", "PRCC", "PRCP", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PREPL", "PRIM1", "PRIM2", "PRKAA1", "PRKAA2", "PRKACA", "PRKAG1", "PRKAR1A", "PRKAR2A", "PRKCB", "PRKCSH", "PRKDC", "PRMT1", "PRMT5", "PRPF19", "PRPF3", "PRPF31", "PRPF38B", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPS2", "PRPSAP1", "PRPSAP2", "PRRC1", "PRRC2C", "PSAP", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD6", "PSMD7", "PSMD8", "PSME1", "PSME2", "PSME3", "PSME4", "PSMG1", "PSMG2", "PSPC1", "PTBP1", "PTBP2", "PTCD1", "PTCD3", "PTDSS1", "PTDSS2", "PTGES2", "PTGES3", "PTK2", "PTK7", "PTPA", "PTPN1", "PTPN23", "PTPRF", "PTRH2", "PUM3", "PURA", "PUS1", "PWP1", "PWP2", "PXMP2", "PXN", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QKI", "QRSL1", "QSOX2", "QTRT2", "RAB10", "RAB12", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB1B", "RAB23", "RAB24", "RAB2A", "RAB34", "RAB35", "RAB3B", "RAB3GAP1", "RAB3GAP2", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RAB8A", "RAB9A", "RABEPK", "RABGAP1", "RABGGTA", "RABL6", "RAC1", "RACGAP1", "RACK1", "RAD18", "RAD21", "RAD23A", "RAD23B", "RAD50", "RAE1", "RAI14", "RALA", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP9", "RANGAP1", "RAP1GDS1", "RAPGEF2", "RARS", "RARS2", "RBBP4", "RBBP5", "RBBP6", "RBBP7", "RBM10", "RBM12", "RBM12B", "RBM14", "RBM17", "RBM19", "RBM22", "RBM25", "RBM27", "RBM28", "RBM3", "RBM34", "RBM39", "RBM4", "RBM45", "RBM5", "RBM8A", "RBMX", "RBMXL1", "RBPJ", "RCC1", "RCC2", "RCL1", "RCN1", "RCN2", "RDH11", "RDH13", "RDH14", "RDX", "RECQL", "REEP4", "REEP5", "RER1", "RETSAT", "REXO2", "REXO4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RFT1", "RHBDD2", "RHEB", "RHOG", "RHOT1", "RHOT2", "RIDA", "RIF1", "RINT1", "RIPK1", "RMDN1", "RMDN3", "RNASEH2A", "RNASET2", "RNF2", "RNF20", "RNF40", "RNMT", "RNPS1", "ROBO1", "ROCK1", "ROCK2", "RP2", "RPA1", "RPA2", "RPAP3", "RPF1", "RPF2", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPN1", "RPN2", "RPP30", "RPP38", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS26", "RPS28", "RPS29", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RPTOR", "RPUSD3", "RRAS2", "RRBP1", "RREB1", "RRM1", "RRM2", "RRP1", "RRP12", "RRP15", "RRP1B", "RRP36", "RRP8", "RRP9", "RRS1", "RSF1", "RSL1D1", "RSL24D1", "RSU1", "RTCB", "RTFDC1", "RTN1", "RTN2", "RTN3", "RTN4", "RTN4IP1", "RTRAF", "RUFY1", "RUVBL1", "RUVBL2", "S100A11", "S100A13", "SACM1L", "SAE1", "SAFB", "SAFB2", "SAMD4B", "SAMHD1", "SAMM50", "SAP130", "SAP18", "SAP30BP", "SAR1A", "SAR1B", "SARM1", "SARNP", "SARS2", "SART1", "SART3", "SBDS", "SCAF1", "SCAF11", "SCAMP1", "SCAMP2", "SCAMP3", "SCAMP4", "SCARB1", "SCARB2", "SCCPDH", "SCD", "SCFD1", "SCFD2", "SCML2", "SCO1", "SCO2", "SCP2", "SCRIB", "SCRN1", "SCYL1", "SDAD1", "SDF4", "SDHA", "SDHB", "SDHC", "SEC11A", "SEC16A", "SEC22B", "SEC23A", "SEC23B", "SEC23IP", "SEC24A", "SEC24B", "SEC24C", "SEC31A", "SEC61A1", "SEC61B", "SEC62", "SEC63", "SEH1L", "SEL1L", "SENP3", "SEPT11", "SEPT2", "SEPT7", "SEPT9", "SERBP1", "SERPINB6", "SERPINH1", "SET", "SETD1A", "SETD2", "SETD3", "SETDB1", "SEZ6L2", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFXN1", "SFXN2", "SFXN4", "SGF29", "SGPL1", "SGTA", "SH3GL1", "SH3GLB1", "SHCBP1", "SHMT2", "SHTN1", "SIGMAR1", "SIN3A", "SKA1", "SKA3", "SKIV2L2", "SKP1", "SKP2", "SLC12A2", "SLC16A1", "SLC19A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A16", "SLC25A17", "SLC25A19", "SLC25A20", "SLC25A21", "SLC25A24", "SLC25A25", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A33", "SLC25A4", "SLC25A44", "SLC25A5", "SLC25A6", "SLC27A4", "SLC33A1", "SLC35A4", "SLC35B2", "SLC39A14", "SLC3A2", "SLC4A2", "SLC5A6", "SLC7A1", "SLC9A3R1", "SLFN11", "SLIRP", "SLK", "SLMAP", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC5", "SMC6", "SMCHD1", "SMG1", "SMG5", "SMN1*", "SMNDC1", "SMPD4", "SMU1", "SND1", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPC", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNU13", "SNW1", "SNX1", "SNX17", "SNX19", "SNX2", "SNX27", "SNX3", "SNX5", "SNX6", "SNX9", "SOAT1", "SOD2", "SON", "SORD", "SORT1", "SPAG5", "SPAG9", "SPART", "SPATA5", "SPATA5L1", "SPATS2L", "SPC25", "SPCS2", "SPCS3", "SPDL1", "SPECC1L", "SPEN", "SPNS1", "SPOUT1", "SPPL2A", "SPTAN1", "SPTBN1", "SPTLC1", "SPTLC2", "SQLE", "SRC", "SRCAP", "SREK1", "SRI", "SRP14", "SRP54", "SRP68", "SRP72", "SRP9", "SRPK1", "SRPK2", "SRPRA", "SRPRB", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF3", "SRSF4", "SRSF5", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSR1", "SSR4", "SSRP1", "STAG1", "STAG2", "STAM", "STAM2", "STAT1", "STAT3", "STAU1", "STAU2", "STIP1", "STK26", "STK4", "STMN1", "STOM", "STOML2", "STRAP", "STRBP", "STRN", "STT3A", "STT3B", "STUB1", "STX10", "STX12", "STX16", "STX18", "STX4", "STX7", "STX8", "STXBP2", "STXBP3", "STXBP4", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGP2", "SUGT1", "SUN1", "SUN2", "SUPT16H", "SUPT3H", "SUPT5H", "SUPT6H", "SUPV3L1", "SURF6", "SUZ12", "SV2A", "SYAP1", "SYMPK", "SYNCRIP", "SYNE1", "SYNE2", "SYNGR2", "SYNJ2BP", "SYS1", "TAB1", "TACC3", "TAF15", "TAF6", "TAMM41", "TAP1", "TAP2", "TARDBP", "TARS2", "TBCA", "TBCB", "TBCD", "TBCE", "TBL1XR1", "TBL2", "TBL3", "TBRG4", "TCEA1", "TCERG1", "TCOF1", "TCP1", "TCP11L1", "TDRKH", "TECR", "TEFM", "TELO2", "TERF2IP", "TES", "TEX10", "TEX264", "TFAM", "TFB1M", "TFCP2", "TFG", "TFIP11", "TFRC", "TGFBRAP1", "TGOLN2", "THADA", "THAP11", "THOC1", "THOC2", "THOC3", "THOC5", "THOC6", "THOP1", "THRAP3", "TIA1", "TIAL1", "TIGAR", "TIMM10B", "TIMM17B", "TIMM23", "TIMM44", "TIMM50", "TIMM8B", "TJP1", "TJP2", "TKT", "TLE3", "TLK2", "TLN1", "TM9SF2", "TM9SF4", "TMA16", "TMCO1", "TMED10", "TMED2", "TMED7", "TMED9", "TMEM109", "TMEM11", "TMEM115", "TMEM126A", "TMEM14C", "TMEM167A", "TMEM192", "TMEM199", "TMEM201", "TMEM214", "TMEM230", "TMEM259", "TMEM33", "TMEM43", "TMEM65", "TMEM87A", "TMEM97", "TMLHE", "TMOD3", "TMPO", "TMPO", "TMTC3", "TMX1", "TMX2", "TMX3", "TNKS1BP1", "TNPO1", "TNPO3", "TOE1", "TOMM20", "TOMM22", "TOMM34", "TOMM40", "TOMM5", "TOMM70", "TOP1", "TOP2A", "TOP2B", "TOPBP1", "TOR1A", "TOR1AIP1", "TOR1AIP2", "TOR1B", "TOX4", "TP53", "TP53BP1", "TP53BP2", "TPBG", "TPD52", "TPM3", "TPM4", "TPP1", "TPP2", "TPR", "TPT1", "TPX2", "TRA2A", "TRA2B", "TRAF2", "TRAP1", "TRAPPC11", "TRAPPC4", "TRAPPC5", "TRIM13", "TRIM21", "TRIM25", "TRIM27", "TRIM28", "TRIO", "TRIP12", "TRIP13", "TRIP4", "TRMT10C", "TRMT6", "TRMU", "TROVE2", "TRRAP", "TRUB1", "TSFM", "TSG101", "TSN", "TSNAX", "TSPAN3", "TSPAN6", "TSPO", "TSR1", "TST", "TTC1", "TTC19", "TTC26", "TTC28", "TTC37", "TTF2", "TTK", "TTLL12", "TTYH3", "TUBB", "TUBB2A", "TUBB2B", "TUBB3", "TUBB4A", "TUBB6", "TUBGCP2", "TUBGCP3", "TUFM", "TWF2", "TWNK", "TXLNG", "TXNDC12", "TXNDC15", "TXNDC5", "TXNDC9", "TXNL1", "TXNRD1", "TYMS", "U2AF1", "U2AF2", "UBA1", "UBA2", "UBAC1", "UBAP2L", "UBE2J1", "UBE2K", "UBE2L3", "UBE2N", "UBE2O", "UBE2S", "UBE3A", "UBE3C", "UBE4A", "UBLCP1", "UBQLN4", "UBR2", "UBR4", "UBR5", "UBTF", "UBXN1", "UBXN4", "UBXN7", "UCHL5", "UFD1", "UFL1", "UFM1", "UGCG", "UGGT1", "UGT8", "UHRF1", "UNC45A", "UPF1", "UPF2", "UPF3B", "UQCC2", "UQCR10", "UQCRB", "UQCRC1", "UQCRC2", "UQCRFS1", "UQCRQ", "URB1", "USMG5", "USO1", "USP10", "USP11", "USP14", "USP19", "USP28", "USP36", "USP39", "USP47", "USP48", "USP5", "USP7", "USP9X", "UTP11", "UTP14A", "UTP15", "UTP18", "UTP20", "UTP3", "UTP4", "UTP6", "UTRN", "VAMP7", "VANGL1", "VANGL2", "VAPA", "VAPB", "VARS1", "VARS2", "VAT1", "VBP1", "VCL", "VCP", "VDAC1", "VDAC2", "VDAC3", "VIM", "VIPAS39", "VIRMA", "VPS13A", "VPS13C", "VPS16", "VPS18", "VPS26A", "VPS29", "VPS33A", "VPS33B", "VPS35", "VPS37B", "VPS45", "VPS4A", "VPS4B", "VPS50", "VPS51", "VPS52", "VPS53", "VRK1", "VRK3", "VTA1", "WAPL", "WASHC4", "WASHC5", "WBP11", "WBP2", "WDHD1", "WDR1", "WDR11", "WDR12", "WDR18", "WDR26", "WDR3", "WDR33", "WDR36", "WDR4", "WDR41", "WDR43", "WDR46", "WDR5", "WDR61", "WDR73", "WDR74", "WDR75", "WDR77", "WDR82", "WDR91", "WFS1", "WIPI2", "WIZ", "WLS", "WRAP73", "WRNIP1", "WTAP", "XAB2", "XPNPEP3", "XPO1", "XPO4", "XPO5", "XPO7", "XPOT", "XRCC1", "XRCC5", "XRCC6", "XRN2", "XXYLT1", "YARS", "YARS2", "YEATS2", "YEATS4", "YIF1A", "YKT6", "YLPM1", "YME1L1", "YTHDC1", "YTHDC2", "YTHDF2", 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sha256:373c55f9304b50b74d2c1ed484e159806d76cde50c21b30e2bab84932314f835 +size 147111 diff --git a/msigdb_gomf/basic/plot_6.png b/msigdb_gomf/basic/plot_6.png new file mode 100644 index 0000000000000000000000000000000000000000..81303a55ee9bc6c30e15e46751631b172b326570 --- /dev/null +++ b/msigdb_gomf/basic/plot_6.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:0a2d1e0af79a9b5a1177cf3d9693679e9f1a19b5c93a9f22e679c07385d2e5e6 +size 139743 diff --git a/msigdb_gomf/basic/plot_7.png b/msigdb_gomf/basic/plot_7.png new file mode 100644 index 0000000000000000000000000000000000000000..3675266d1dc305639dbeb6e745d62cb9d27e8ccd --- /dev/null +++ b/msigdb_gomf/basic/plot_7.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:327a9b0ad722018c23aeb39fabb912d163884db6a52ae867b4c14b086b4b0097 +size 137873 diff --git a/msigdb_gomf/basic/plot_8.png b/msigdb_gomf/basic/plot_8.png new file mode 100644 index 0000000000000000000000000000000000000000..eff69ceb0ba6b97a8469d8d893827994a4b4a31b --- /dev/null +++ b/msigdb_gomf/basic/plot_8.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:31cbd1b35eaa639c02b62876ee4e8a5417e37e2e61fc8118c49e9dd9d6afc747 +size 141069 diff --git a/msigdb_gomf/basic/plot_9.png b/msigdb_gomf/basic/plot_9.png new file mode 100644 index 0000000000000000000000000000000000000000..f9f40e8cf9a7673555d2caec4d9a860bdcec8f89 --- /dev/null +++ b/msigdb_gomf/basic/plot_9.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:3f6e50dacc8df81e2faf64a833204ed080cda48db433d1c0546dc634d649decb +size 145661 diff --git a/msigdb_gomf/consensus.joblib b/msigdb_gomf/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..144c592206d1442fb9a12321036679d953a7e754 --- /dev/null +++ b/msigdb_gomf/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:9857658c8fd834fc8b519abaedbb91b50fc7cf3b7b1cba9aac3b0e7dc7048e61 +size 169991 diff --git a/msigdb_gomf/df_merge.tsv b/msigdb_gomf/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..4786e5a06fe63e5629b61441b97a5fddc9dfcae3 --- /dev/null +++ b/msigdb_gomf/df_merge.tsv @@ -0,0 +1,74 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Cation transmembrane transporter activity 41 70 4.551780256281546 5.3193878719604015e-06 25.62135922330097 70.51699029126213 1.766742880952279 0.2698419237572138 12.29126021871486 8.422243011776631 2.00238274385689 0.3706372466673562 1.7488384729258294e-08 0.3052095683601886 0.0003677113139399 1.173309482010712e-05 7.545340166431103e-07 +Inorganic molecular entity transmembrane transporter activity 45 78 4.232257049260952 2.3135777141192196e-05 28.058252427184467 75.9635922330097 1.5031303400189615 0.2894264293069549 11.721339963426631 9.38477049228959 2.153051736566399 0.3821536813265525 1.3646079986925848e-11 0.0288713637898469 2.02385257794216e-05 9.080908045967253e-08 4.4788061268478925e-10 +Ion transmembrane transporter activity 59 104 3.797619806180175 0.0001460921711573 37.34466019417476 101.497572815534 2.0154097423383375 0.2561362875319209 17.172953606300336 11.579295798802024 2.277787478419462 0.3756175790939143 6.933350234457404e-16 0.0160739624847947 1.404548621600609e-06 3.241398461306061e-10 3.1957693051666744e-14 +Active transmembrane transporter activity 44 82 3.731598050545744 0.0001902689247725 26.354368932038835 73.12621359223301 1.313035419122872 0.3239574057550545 11.878456281473593 8.663537710607383 1.88741562841277 0.3851687956916088 1.5372582810037078e-10 0.072705670789428 0.0032633994856491 7.483219883171371e-06 1.6493713629337745e-12 +Anion transmembrane transporter activity 31 48 3.379726141497487 0.0007255808854282 18.594660194174757 45.61893203883495 1.6222323024349488 0.2373683627198559 9.346785472607134 6.017202751823004 1.8117646078257517 0.3183345645365742 5.3794478265406316e-12 0.022467997482696 0.001316320715177 3.380317006252405e-07 7.482093225657308e-12 +Primary active transmembrane transporter activity 31 60 3.369514464086877 0.0007530073902948 17.696601941747574 52.529126213592235 1.0080198242353189 0.3544097082146772 7.649017203625277 6.455721193615876 1.66885648871365 0.3767837436492733 1.4171687813718649e-08 0.0197758267942588 0.0010223036052096 0.0001474197538178 7.783821458438002e-11 +Transporter activity 101 182 3.33913035148452 0.0008404111821063 62.22330097087379 172.27912621359224 2.173366592838491 0.2707201784543502 25.984753572620328 19.29276868436311 2.593156143256053 0.3916539604106395 7.833496537106759e-27 4.366710292485098e-06 7.295223351126636e-11 3.4019829952280746e-14 1.3187083776716295e-27 +Steroid binding 11 22 3.321831168467961 0.0008942878761368 8.424757281553399 21.398058252427184 1.4469817519716153 0.1523451695819165 3.035656818503787 2.066091501771892 1.85140774519605 0.2395996334984524 3.3548694761700144e-06 0.0230489069918226 6.76794881948827e-06 1.964483782727492e-05 2.672510894072328e-06 +Tetrapyrrole binding 10 18 3.318178867493293 0.0009060644254781 7.402912621359223 16.83252427184466 2.0044897428967667 0.1259264696495541 2.9589081005845346 2.0417036568087963 1.3464702305086589 0.2177422235164347 9.16441898032592e-06 5.509963742625166e-06 1.2025466891765146e-05 4.084602018344024e-05 4.524440963497809e-05 +Active ion transmembrane transporter activity 27 46 3.2612557960629607 0.0011091992906679 16.271844660194176 41.71116504854369 1.2957221273899948 0.3267733012969381 7.788084220174416 5.097264791179653 1.6571109350293016 0.3632481416270505 1.038562841149272e-08 0.4354616437047781 0.0267992171546872 2.6388281594667528e-05 4.242537455411596e-08 +Proton transmembrane transporter activity 19 36 3.2550843592518457 0.0011335868890398 12.769417475728156 35.478155339805824 1.2352045534927034 0.2879171268332734 5.319202861157036 2.7149368379617917 1.7021108079122016 0.3308025072902738 4.861110244591393e-09 0.0490886173861251 7.389910731518841e-05 1.735385588410225e-07 6.16515920781819e-08 +Secondary active transmembrane transporter activity 18 23 3.0998441229540714 0.001936225116746 9.080097087378642 21.490291262135923 1.2627683473613005 0.2947710034053126 5.466215032972134 3.0675886156990426 1.4241587428281404 0.3340388164945335 0.0008792451793853 1.0 0.5741114914523541 0.005278714475123 0.0010628219793773 +Protein transporter activity 9 14 3.0054693691474563 0.0026517130285881 6.053398058252427 14.696601941747574 1.6882240898296943 0.1359359142649309 2.957968193176 1.443999336657768 1.4805047019217734 0.2345897542974644 4.286839976697619e-06 0.0063255491406275 0.0237627189197599 0.0002808583984775 1.1237436337996233e-07 +Hydrolase activity hydrolyzing o glycosyl compounds 11 19 3.003923083390827 0.0026652269556686 8.830097087378642 20.84223300970874 0.5983257656540719 0.2104301479001341 3.2223833352824554 2.4557961681485057 1.9540573665272416 0.2728112677124137 0.0006549381687891 0.2068720246529641 0.0775813155228076 0.0280832529132891 8.197910505732385e-05 +Electron transfer activity 23 55 2.987785808658248 0.0028100641514288 14.919902912621358 52.12621359223301 0.5312195787834075 0.4459804256520286 6.65997259318913 4.498499451328372 1.405540355221493 0.3721784721862224 1.2173353437505003e-05 0.0013159065844929 0.0003891202112714 0.0006738151606936 2.618351703486e-07 +Metal ion transmembrane transporter activity 14 24 2.981230668904495 0.0028709245569147 9.563106796116504 24.67233009708738 0.8657396859235934 0.3700615753207195 4.93288923178502 4.839352380624028 1.4450904591933955 0.3424002804304004 0.0621990789143533 1.0 0.3281099840481742 0.172108822769145 0.1383697049953699 +Sphingolipid binding 5 10 2.9768185584618982 0.0029125632402242 3.2305825242718447 6.810679611650485 1.3881601090528384 0.1287371848492678 1.3662849673921555 1.293404675510669 1.5116584105270494 0.2146285912590262 5.5105284909181895e-05 8.090961716756818e-05 2.214575962840231e-05 2.7013551728451183e-06 0.0001429815632908 +Anion channel activity 10 12 2.8779554418887665 0.0040026167050588 4.20873786407767 11.21116504854369 1.03959259790327 0.2192420598609839 2.3076742714116403 2.0905640066649145 1.3937691950814175 0.2662450395835827 1.014685737864641e-06 0.0078974776787256 0.0001376480525375 4.476197901851534e-05 4.205073922679249e-06 +Passive transmembrane transporter activity 18 34 2.8181203026669994 0.0048305706925566 10.728155339805824 34.00242718446602 0.8598494327527568 0.3171523987434088 5.464704354730218 4.259483301090722 1.5882390061019254 0.3339692919660049 5.9336932974035175e-05 0.0172741819727463 0.0007816352528268 0.0062659657814626 0.0001173760982385 +Ceramide binding 4 7 2.772102852058973 0.0055695435642419 2.8228155339805827 5.048543689320389 1.42330045764979 0.1242195400491618 1.17628831869178 0.9309003969609838 1.481980135982154 0.2133994029014766 0.0001094986389743 2.8841975049086312e-05 5.369271916582234e-06 8.624555272386569e-06 0.0002457979454447 +Organic anion transmembrane transporter activity 19 30 2.7202704095108894 0.0065228550869005 12.951456310679612 30.182038834951456 1.56101282472555 0.2452312368187786 6.880574373146614 3.5222410835885483 1.575669523214114 0.314839840161206 1.5157846984276796e-06 0.3371313972628795 0.1967082241040804 0.0009941384248502 2.631621948630412e-06 +Antiporter activity 8 12 2.68709242009383 0.0072077006729078 4.621359223300971 10.405339805825244 1.056576117278179 0.2813324268221227 2.679901841610502 1.304685592846984 1.2558310293487471 0.3063102364368053 0.0008992523581328 1.0 0.3143397790261298 0.0023124348467711 0.0004730993907641 +Macromolecule transmembrane transporter activity 6 11 2.6783627609275125 0.007398304347197 4.820388349514563 12.281553398058252 1.6605285757306012 0.1306403746261988 2.4754663863133306 1.0160601209961664 1.3599823000893485 0.2280235038874096 0.0010403956302503 0.0040679264544396 0.0155240337321844 0.0828772873031817 2.7180346417726147e-05 +Alcohol binding 11 18 2.6393659959768185 0.0083061253819274 5.70873786407767 16.094660194174757 1.0972550148478282 0.1642412137618775 2.3364194162363723 2.1334758164294443 1.72577974721897 0.2306417307890987 0.0156631635216302 0.2145132052152406 0.0013172485850202 0.03203241935523 0.0099411678564375 +Sterol binding 8 17 2.611697298951392 0.0090093985476795 5.495145631067961 16.27912621359223 1.1610523788441311 0.1592175050218891 2.159304933149918 1.9111962434971217 1.7231989277496158 0.231586711794193 0.0030984377022794 0.1594721229818057 0.0003733671894444 0.0106277501006418 0.0014896299843671 +Metallopeptidase activity 21 40 2.610574088014784 0.009039039025424 11.548543689320388 40.60436893203884 1.2053444242445344 0.3510417366391842 4.586289489033314 2.1135899474190585 1.0988837346562612 0.3462572593421246 0.0014932354789087 1.0 0.5396055987962411 0.1274569302589828 0.0015858816854951 +Protein transmembrane transporter activity 6 10 2.6078130506929 0.0091122706004187 4.37621359223301 11.264563106796116 1.6409152716253632 0.1284874270119089 2.3258190399954897 0.995332092405782 1.387057072324357 0.2266762256512647 0.0004596106373318 0.0029386578360865 0.0113213926532688 0.0621585272883563 7.746328029618005e-06 +Cholesterol binding 8 14 2.583689130639549 0.0097749856267461 5.25 13.29126213592233 1.1679703080780182 0.1357521674166823 1.9454015982929531 1.7674569958716484 1.7544522374432017 0.2116991383290636 0.0011616991370565 0.134742527043449 0.0001815434943904 0.0055331858379351 0.0004675519327548 +Hydrolase activity acting on glycosyl bonds 12 28 2.5633044099714266 0.0103681099907322 10.133495145631068 28.40776699029126 0.6089784953463463 0.2409908190925149 3.36301188653944 3.2424277527979313 1.935823411407979 0.3010513017078077 0.0027991925588535 0.297366720714231 0.1554832015057707 0.0312610879309806 0.0007310207327381 +Snap receptor activity 8 12 2.553836371152368 0.01065433126912 5.803398058252427 13.6626213592233 0.8920027438628428 0.3386294703372389 3.103034547770364 2.9171839264116786 1.2201519782198902 0.3219991979242683 0.0116776996200851 0.151306852499084 0.0041517217414646 0.0479498850625808 0.0229507437408614 +Carbohydrate derivative transmembrane transporter activity 8 10 2.5450580108038405 0.0109259585230869 4.672330097087379 10.12135922330097 1.0096229459917263 0.2944050311743799 2.686158589641687 1.471354338494036 1.2935479322863277 0.3146313980204608 6.089326540677955e-05 1.0 1.0 0.0032545859437725 0.0001788650990257 +Metalloendopeptidase activity 11 14 2.540204242483183 0.011078775067282 5.449029126213592 14.364077669902912 1.4597326207035937 0.2246869419023046 2.4848715129851016 0.6671711573432166 0.9390012824303952 0.2775881383017788 0.0019536637913722 1.0 0.2732850813359189 0.0444854600227105 0.0045924061823516 +P type transmembrane transporter activity 6 8 2.532636638764469 0.0113208237885129 2.842233009708738 5.473300970873787 0.6050493013674468 0.3730987003611934 1.6045635356324264 1.3712604140019378 1.17652933932801 0.3174788438558891 6.971717076711458e-05 1.0 0.1094892401774078 0.032628233248221 0.0001575214550341 +Exogenous protein binding 4 15 2.491294721529992 0.0127278492482516 4.509708737864078 15.157766990291265 0.7214109752050332 0.2527966464979699 2.499010078306418 1.9009100692398744 1.5211756979359785 0.2791170769282048 0.0356515059560401 1.0 0.0693457394610891 0.0227330174276438 0.0655768501043339 +Oxidoreduction driven active transmembrane transporter activity 15 32 2.474321286615271 0.0133489588724278 9.733009708737864 29.83252427184466 0.7626445826297276 0.3795490924215395 4.629116134249794 3.4519743101246267 1.4198222355288384 0.35536187545778 3.623618906662231e-05 0.0032330061916283 0.0003105660221664 0.0006936045596716 6.630045640624705e-06 +Monooxygenase activity 5 9 2.473861321085408 0.0133661569284282 4.043689320388349 8.322815533980583 1.6049222537693364 0.1501440468766332 1.612461779657682 1.2307404965531048 1.237349324058907 0.2369071661653372 0.0006425116636896 7.617069837983664e-06 5.053603155069604e-06 3.588913913812074e-05 0.0015706126808535 +Voltage gated anion channel activity 5 7 2.4644665305501805 0.0137217378180536 2.854368932038835 6.25 1.127126362633441 0.1649553590552043 1.5417035527207152 0.9966570336472054 1.4583344406160936 0.2334940994157564 8.247959453968683e-07 0.0470522829573702 9.839858993160587e-05 1.7923085924657402e-06 2.2585304294532336e-06 +Nucleobase containing compound transmembrane transporter activity 9 15 2.446067249895955 0.0144424058971173 6.529126213592233 14.04126213592233 1.4296604886183193 0.212054291115069 3.2696940585469636 1.915888183904924 1.3255809572534116 0.2748813593420038 3.3788559375589185e-07 0.0102371045657047 0.0376249374527164 9.930378297861054e-05 1.6299327440176916e-06 +Inorganic anion transmembrane transporter activity 15 21 2.415133999580298 0.0157294217807677 7.427184466019417 19.274271844660195 1.0921593405593897 0.2441056926448881 3.717191605498929 3.7816647851785734 1.4014196343960104 0.2816216967014333 8.726244201353619e-07 0.0257535715284909 0.0015259573241502 3.079730523933523e-05 7.915219655591412e-07 +Transition metal ion transmembrane transporter activity 4 5 2.3825993243315104 0.01719089377589 2.2597087378640777 4.444174757281553 1.267846808399692 0.205487024774009 1.5353529408674886 1.9618423203326616 1.2931295194130703 0.2516620757205828 0.0024924187730192 1.0 0.2070995190727305 0.0193169154759243 0.0052134507581354 +Hexosyltransferase activity 13 36 2.3779127578367616 0.0174109447036205 9.633495145631068 33.87864077669903 0.7349501031127185 0.3949358882560483 4.261380470236419 4.330948695045228 1.2646745007039175 0.3422146027467064 0.0437057008123035 0.4243503559946278 0.0968104322956701 0.0062659657814626 0.0223997067615021 +Molecular transducer activity 14 35 2.3616834174092545 0.0181921702008234 10.91747572815534 33.40533980582524 1.343848990749489 0.2329582295822712 4.7124072380860955 5.830391636254363 1.6098335072319665 0.2956883791113679 0.6150520623749135 0.7160221244847005 0.2361029888435318 0.5944333056930783 0.7144299253044021 +Protein carrier chaperone 4 8 2.352352902741259 0.01865506662524 3.3980582524271843 10.118932038834952 0.8288787693114796 0.3398938251553178 1.8569721980092944 2.0920401213092656 1.1849901066971258 0.3127406939001886 0.0006151896190365 1.0 0.0126574737404708 0.0007750266814789 0.0013369974246366 +Atpase coupled transmembrane transporter activity 20 28 2.321205746186412 0.0202757422122075 8.072815533980583 22.696601941747577 0.8561067713091313 0.3392846662603397 4.166386392056555 3.892074110340729 1.3163009809214623 0.3229730128136945 0.0001053468440953 1.0 0.4297892617739207 0.0509365284789281 3.0095640750750782e-06 +Oxidoreductase activity acting on a heme group of donors 5 7 2.304581607918097 0.0211900170103511 3.111650485436894 6.483009708737864 0.8850005512180296 0.2757097651603665 1.538237610319269 1.0226572421183926 1.2777814224392188 0.2966482201944345 0.0002387045154679 1.0 0.1349531130589082 0.0050923434600555 0.0005289198821125 +Peptide binding 22 73 2.298490304550371 0.0215338990763416 17.133495145631066 70.30339805825243 1.21997288878307 0.3503559587509399 5.621054768990946 6.443005397350486 1.219878183292811 0.3773673755377006 0.0071736473140743 0.5099697930744801 0.7607041245739496 0.0259252536664186 8.715510352395108e-05 +Proton transporting atp synthase activity rotational mechanism 3 10 2.2755526798361445 0.022872796282213 3.655339805825242 10.75485436893204 0.46898650441807 0.3141755537304957 2.268964442606705 0.8649601417133376 1.3429609354721883 0.2856466957651606 0.0033918567435536 0.0742352733278267 0.0100519320580488 0.0557098434243155 0.0062633876942655 +Proton channel activity 3 10 2.2755526798361445 0.022872796282213 3.655339805825242 10.75485436893204 0.46898650441807 0.3141755537304957 2.268964442606705 0.8649601417133376 1.3429609354721883 0.2856466957651606 0.0042940863146269 0.0786913117950012 0.0113213926532688 0.0621585272883563 0.0078812527225172 +Mhc protein binding 5 9 2.2718319592091656 0.0230966617577985 3.094660194174758 8.968446601941748 0.6294582460885748 0.3884738618046354 1.6140375204875843 0.8821171105149307 1.0893111588562217 0.3109068508502701 0.1098597143392657 1.0 1.0 0.2897526236095206 0.0003671727016274 +Membrane insertase activity 3 5 2.264501709877043 0.0235432747102632 2.737864077669903 7.388349514563107 0.8099367695235317 0.306513025583228 1.5809003521008822 1.7333564146948666 1.2685525479217892 0.3048480656363501 0.0019907060593634 1.0 0.0077184558590264 0.0041470760753771 0.003721367796782 +Atpase coupled cation transmembrane transporter activity 11 17 2.2549633734081964 0.0241356278689608 4.798543689320389 14.434466019417476 0.5910750448608943 0.4613904105338446 2.543924385121825 1.7948352160376215 0.9540113823486516 0.3207668712362007 0.0001299034750473 1.0 0.2445730022705269 0.0319451393300601 0.000373895250662 +O acyltransferase activity 9 14 2.249223718878869 0.0244982661503136 4.711165048543689 12.395631067961164 0.9877600518928406 0.2684789023147002 2.6842893514436073 2.3496085895491885 1.2379749168209273 0.2720543739153138 0.0090332289343176 1.0 1.0 0.5428479192551358 0.0007105677029561 +Mhc class i protein binding 4 8 2.2402378160039103 0.0250754878422618 2.7135922330097086 7.936893203883495 0.4997309801019018 0.4236810840517632 1.5643199175999352 0.8594975153459443 1.0647070901951394 0.3142832966160581 0.0719012577032834 1.0 1.0 0.2356930071839008 9.569573614901708e-05 +Calcium ion binding 24 84 2.226332277379899 0.0259919329993216 21.00485436893204 81.67961165048544 0.6464856503310022 0.4940276647939897 7.408010340962093 8.52860815905726 1.2261945166831902 0.3858741960292539 0.0047806526949649 0.3860509975104039 0.1278733559720672 0.0072539794291604 0.0020599769114261 +Glycolipid binding 3 12 2.21449005223941 0.0267950862689057 3.95873786407767 9.17233009708738 1.1300394975336625 0.1723818604496332 1.779261971800237 1.789101691327159 1.517965150696512 0.2390589148665743 0.0004596106373318 6.765318543664244e-05 0.0005309775927247 0.0006143549700213 0.0010053263520343 +Atp transmembrane transporter activity 5 6 2.1533484807773293 0.0312913012955315 3.058252427184466 5.456310679611651 0.5680189081478334 0.3318090311699867 1.598392655736251 0.6936144116307477 1.3025695117924114 0.3140848719976767 0.0001693477472854 1.0 1.0 0.1775366954381628 0.0003286021100258 +Nucleotide transmembrane transporter activity 8 13 2.144486128882628 0.0319939556892607 5.606796116504855 12.029126213592232 1.4217258291760082 0.2036087501116975 3.0234925518113496 1.8899648667798992 1.291115513359647 0.2666064512499804 5.5766986338018623e-08 0.0044823878286489 0.0170518298819148 0.0001164002838048 2.4286062180741856e-07 +Organophosphate ester transmembrane transporter activity 8 13 2.144486128882628 0.0319939556892607 5.665048543689321 12.143203883495143 1.4298365636921646 0.2056324024803549 3.029697948284232 1.927415248708952 1.2819429632405106 0.2680490563295835 9.098537684765649e-08 0.0049155620827658 0.018640880521655 0.0001476913167928 3.934289731427105e-07 +Gated channel activity 7 13 2.1050845084568786 0.0352839524849852 4.317961165048544 13.019417475728156 0.8697524591818097 0.2583579989367679 2.2914716766946497 2.0107989163575497 1.3733766112751231 0.2762671399351702 0.0028974265815251 0.0335548880884004 0.0025924072114898 0.0031264397563519 0.0080767934135705 +Solute cation symporter activity 6 7 2.0782550236179405 0.0376858765902936 2.854368932038835 7.206310679611651 0.8639239563858236 0.3319920905256767 1.9640347167867271 2.0653542869596597 1.117186698589392 0.3146562336443082 0.1509164607438732 1.0 1.0 0.1887844423268079 0.2143350029099695 +Phosphatidylcholine binding 2 9 2.074363433050185 0.038045570698282 2.2524271844660193 7.929611650485437 1.2697801287388335 0.1567893034984199 1.081337239384838 1.04388968498945 1.4953842980517238 0.2256102823610289 0.0255771152801701 0.0742352733278267 0.000440337804097 0.0061570039439817 0.0397387250697101 +Peptide antigen binding 4 6 2.0360412408167474 0.041746214229609 2.25 5.218446601941747 1.3488418251083294 0.2076946662826 1.4985834735457568 1.269832767279765 0.9581301458127084 0.2397273125927817 0.4657083464778854 1.0 1.0 0.3069124011154697 0.0048822579474643 +Oxidoreductase activity acting on nad p h 13 31 2.0339485859602067 0.0419567795418449 8.531553398058252 29.633495145631063 0.3474448637287304 0.4517187142808695 4.100257452793358 3.3245401780708717 1.1430154641923982 0.3174571972624041 0.0015290283166592 0.0410390344011431 0.0038718963398175 0.0225481074784796 7.825314737739928e-05 +Palmitoyl coa hydrolase activity 0 6 2.031374783758471 0.0422169903985631 1.191747572815534 5.953883495145631 0.3637387732597311 0.3850948781822857 1.494205589618613 0.650100414961731 1.070979172277181 0.2642258095918143 0.3684454852605098 0.0516364610584135 0.1008375048293403 0.2356930071839008 0.4217257773445009 +Endopeptidase activity 27 61 2.029388421717945 0.0424187434755767 19.08495145631068 62.800970873786405 1.5604938505680932 0.2935756148549138 5.629332570724372 6.156865220927466 1.27979578418692 0.359984229645684 0.0012468908513856 1.0 0.4761179790057352 0.0478203719562379 0.0067701334559591 +Hexosaminidase activity 2 5 2.015717498488672 0.0438295247726725 2.5194174757281553 4.973300970873787 0.3568105957806153 0.2227497456156347 1.091499214132507 0.3065083294438748 1.6445593916296413 0.2548912926080147 0.0047446129612751 0.0424464003246627 0.0832836732680532 0.0186627473263165 0.0076703518288617 +Vitamin transmembrane transporter activity 3 6 2.0095546446921984 0.0444783456786022 2.7766990291262137 6.252427184466019 1.4438342367310928 0.182339474606115 1.52603324115363 1.3650879028699858 1.0282691527982806 0.2346378729908682 0.0065553535310396 0.0875404472016038 0.014058804472369 0.0101015401572799 0.0118865434534573 +Cation channel activity 7 19 2.00780758726188 0.044663742276656 6.628640776699029 20.20145631067961 0.2168681550185727 0.4203796109119975 3.66569707500714 2.3934980322982335 1.245793992642405 0.316602380113191 0.185066947101949 0.3007677906227077 0.1588529428511447 0.5365210756997536 0.2898138625392325 +Symporter activity 7 9 1.9906732453960616 0.0465168219293632 3.638349514563106 9.1747572815534 0.9770544165414302 0.3122690599192905 2.3735568316725377 2.065327188945721 1.1044541290009051 0.3081067804681572 0.2679338944519196 1.0 1.0 0.2871762535363917 0.3610395035532395 +Palmitoyltransferase activity 3 5 1.9869237003606048 0.0469308527774887 1.8786407766990292 5.084951456310679 0.875863834441912 0.3421870647647222 1.2306088543936362 0.6827036113457149 1.018188317250868 0.2997914787323893 0.1811525835372729 1.0 1.0 1.0 0.0618109910728358 +Udp glycosyltransferase activity 8 21 1.9802712618829357 0.047673056177768 5.111650485436893 16.645631067961165 0.3599735227181602 0.3819150449260511 2.50187506268716 3.5246228662547776 1.2344018614792536 0.2994506580113357 0.1921548512300711 0.3041527321586795 0.162236447621752 0.1071524979756758 0.1560553988427572 +Acylglycerol o acyltransferase activity 3 8 1.9673973604358408 0.0491374184236756 2.6601941747572817 6.820388349514563 0.8174935736497821 0.2734948556707107 1.708365471336677 1.514259678343348 1.2372108727630755 0.2654117957889352 0.0523012439820394 1.0 1.0 1.0 0.017002584405276 +Lysophospholipid acyltransferase activity 3 7 1.96158295290233 0.0498110585701301 2.4733009708737863 5.805825242718447 0.4588868874829844 0.3808793592027135 1.45207109427004 1.4282738065746603 1.1906123473894044 0.3028968768080747 0.0404477004850345 1.0 1.0 1.0 0.0118865434534573 diff --git a/msigdb_gomf/metrics.json b/msigdb_gomf/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..1e1e15aad7fd20c6e4fd9998a43d1bdbd053dba2 --- /dev/null +++ b/msigdb_gomf/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3221, + "annotations_size": 1377, + "title": "Average number of proteins per term", + "value": 16.697893972403776 +} \ No newline at end of file diff --git a/msigdb_gomf/paths.json b/msigdb_gomf/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..ef8c41b80da774524ce55a2fa627237ed5fe334d --- /dev/null +++ b/msigdb_gomf/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/msigdb_gomf/fragment/C201/C201_val_log2fc"} \ No newline at end of file diff --git a/msigdb_gomf/result.tsv b/msigdb_gomf/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..fc67fec3594d1c57eed6dadf6306cd8f0b98b973 --- /dev/null +++ b/msigdb_gomf/result.tsv @@ -0,0 +1,373 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Cation transmembrane transporter activity 0.671389380653335 4.551780256281546 5.3193878719604015e-06 0.0072980554923894 0.0036623985498454 70 P06576,Q9HC21,P20674,O00400,Q8NE86,P56385,P05141,Q7KZN9,P20020,Q9UDW1,Q9NW15,Q4KMQ2,P55011,P05023,Q9UM00,P16615,P98194,O14548,P24539,P08574,P23634,P00403,Q96ES6,Q13423,P35670,Q04656,O95202,Q70HW3,P13073,Q15043,P30825,Q6P4Q7,O75964,P51790,Q93050,Q9H9B4,Q9HD20,O43808,Q9Y487,P12235,Q9Y619 41 +Inorganic molecular entity transmembrane transporter activity 0.6450064623995343 4.2322570492609515 2.3135777141192193e-05 0.0313562034174896 0.0106193217078076 78 P06576,O00400,P20674,O43681,P56385,Q9C0H2,P05141,Q7KZN9,Q99797,P20020,Q9UDW1,P55011,Q4KMQ2,Q9NW15,P05023,Q9UM00,Q8TDW0,P16615,P98194,O14548,P24539,P08574,P45880,P00403,P21796,Q96ES6,Q13423,P51798,P35670,Q04656,O95202,P0CG08,P13073,Q9Y277,Q15043,Q6P4Q7,O75964,P51790,Q93050,Q9UBX3,P04920,Q9HD20,Q9Y487,Q96S66,P12235 45 +Ion transmembrane transporter activity 0.6268062850341719 3.7976198061801743 0.0001460921711573 0.1822377362368074 0.0502922299209189 104 P06576,O00400,P20674,Q9HC21,O43681,P56385,Q14728,Q9C0H2,P05141,Q9H2D1,Q7KZN9,P20020,Q9UDW1,P55011,Q4KMQ2,Q9NW15,P53007,P05023,Q9UM00,Q8TDW0,P16615,P98194,Q6NUK1,O14548,P24539,P08574,Q8TB61,P23634,P45880,P00403,P21796,Q96ES6,Q13423,P51798,P35670,Q6KCM7,O95202,Q04656,P0CG08,Q70HW3,P13073,Q9Y277,Q9BQT8,Q15043,P30825,Q6P4Q7,O75964,P51790,P12236,Q93050,Q9UJS0,O75746,Q9UBX3,P04920,Q9HD20,Q9Y487,Q96S66,P12235,Q9Y619 59 +Active transmembrane transporter activity 0.5953201888289918 3.731598050545744 0.0001902689247725 0.2305083968377198 0.0524000618823702 82 Q9P0J0,P06576,O00400,P20674,P05141,Q7KZN9,P20020,Q9UDW1,P55011,P53007,P05023,P03886,O43676,P16615,O95139,Q03519,P98194,Q9NRK6,O14548,P08574,P00403,Q96ES6,P51798,P35670,Q04656,O95202,Q15388,P13073,O95168,Q03518,Q15043,O95299,O96000,Q9Y6M9,P51790,P12236,Q9UBX3,P04920,Q9HD20,Q9NUT2,Q9NP58,P51970,P16260,P12235 44 +Anion transmembrane transporter activity 0.6423994350342206 3.379726141497487 0.0007255808854282 0.6319319824609742 0.1134227921712178 48 Q9HC21,O00400,O43681,Q14728,P05141,Q9C0H2,Q9H2D1,Q9NW15,P55011,Q4KMQ2,P53007,Q6NUK1,Q8TB61,P45880,P21796,P51798,Q6KCM7,P0CG08,Q9BQT8,Q9Y277,Q15043,P30825,P51790,P12236,Q9UJS0,O75746,Q9UBX3,P04920,Q96S66,P12235,Q9Y619 31 +Primary active transmembrane transporter activity 0.5709065897350786 3.3695144640868775 0.0007530073902948 0.6455832384804342 0.1134227921712178 60 Q9P0J0,P06576,P20674,Q7KZN9,P20020,Q9UDW1,P05023,P03886,O43676,P16615,O95139,Q03519,P98194,Q9NRK6,O14548,P08574,P00403,P51798,P35670,Q04656,Q15388,P13073,Q03518,O95168,O95299,O96000,Q9Y6M9,Q9HD20,Q9NP58,Q9NUT2,P51970 31 +Transporter activity 0.6471372113105398 3.3391303514845196 0.0008404111821063 0.6858022617746949 0.1134227921712178 182 Q9BSK2,P20674,Q9C0H2,P05141,Q9H2D1,Q9NS69,P20020,Q9UDW1,P55011,Q4KMQ2,Q9UM00,O15173,Q8TDW0,P03886,O43676,O60830,Q9NRK6,P17900,P24539,P08574,P23634,P45880,P21796,Q13423,P35670,O15118,O95202,Q70HW3,P13073,Q9Y277,P30825,P04062,O75964,Q9Y6M9,Q93050,Q9UBX3,Q9HD20,Q9Y487,P16260,L0R6Q1,O00400,P38435,Q7KZN9,P16615,Q8WTV0,O14548,Q9Y5J9,Q8TB61,P51798,Q9Y5J6,Q6KCM7,Q9BQT8,Q15043,P51790,Q9UJS0,Q96S66,Q9Y619,Q9P0J0,O43681,Q96AA3,Q99797,Q9NW15,Q07820,P05023,O14925,P98194,Q6NUK1,Q96H78,P00403,P39210,Q96ES6,Q9H2V7,Q04656,P0CG08,O95168,P61916,Q6P4Q7,Q7Z3C6,P12236,P49755,Q9NUT2,Q9NP58,Q7L0J3,P12235,P06576,Q9HC21,P56385,Q14728,P30536,P53007,O95139,Q03519,O96008,Q8NE01,Q15388,Q03518,O95299,O96000,O75746,P04920,P51970 101 +Steroid binding 0.743678588795842 3.321831168467961 0.0008942878761368 0.7082871533255756 0.1134227921712178 22 Q14108,P38435,P45880,P30536,P61916,P21796,P04062,O00264,P05023,O15173,O15118 11 +Tetrapyrrole binding 0.7921987769115955 3.318178867493293 0.0009060644254781 0.7129837031829533 0.1134227921712178 18 Q6UW02,P09601,P30519,Q7KZN9,Q9NP58,Q9H7Z7,O00264,Q16850,O15173,O43169 10 +Active ion transmembrane transporter activity 0.6372777942126304 3.2612557960629607 0.0011091992906679 0.7830774990234619 0.1200730112467608 46 P06576,O00400,P20674,P05141,Q7KZN9,P20020,Q9UDW1,P55011,P53007,P05023,P16615,P98194,O14548,P08574,P00403,Q96ES6,P51798,P35670,Q04656,O95202,P13073,Q15043,P51790,P12236,P04920,Q9HD20,P12235 27 +Proton transmembrane transporter activity 0.6797545955742851 3.2550843592518457 0.0011335868890398 0.7902490807690083 0.1200730112467608 36 P06576,O00400,P20674,P56385,P05141,Q7KZN9,Q9UDW1,O14548,P24539,P00403,Q96ES6,Q13423,O95202,P13073,O75964,P51790,Q93050,Q9Y487,P12235 19 +Secondary active transmembrane transporter activity 0.6956241895915655 3.0998441229540714 0.001936225116746 0.930662298440988 0.1481212214310745 23 O00400,Q8NE86,Q9Y289,P12236,P53985,Q9UBX3,P05141,P04920,Q15043,Q00325,P55011,Q96ES6,P16260,P53007,P12235,P51798,P51790,O95202 18 +Protein transporter activity 0.7894842256717182 3.0054693691474563 0.0026517130285881 0.974171032872988 0.1671083159078671 14 O60830,O14925,P49755,Q9Y5J9,Q9HD20,Q9NS69,Q07820,O96008,Q9Y5J6 9 +Hydrolase activity hydrolyzing o glycosyl compounds 0.7265674895048005 3.003923083390827 0.0026652269556686 0.9746484888702744 0.1671083159078671 19 Q16706,P16278,P17900,P35573,P06280,P54802,P10253,P04062,P06865,Q9BTY2,Q9NUJ1 11 +Electron transfer activity 0.5581453159265256 2.9877858086582476 0.0028100641514288 0.97924369568661 0.1671083159078671 55 Q9P0J0,P20674,Q7KZN9,Q9UDW1,P03886,O43676,O95139,O43175,O14548,P14406,P08574,P00403,Q99643,O15460,P16435,P48163,P13073,O95168,O95299,O96000,Q9Y6M9,P21912,P51970 23 +Metal ion transmembrane transporter activity 0.6751167892570402 2.981230668904495 0.0028709245569147 0.9809168352553288 0.1671083159078671 24 Q04656,Q8NE86,P98194,P23634,Q9HD20,Q15043,P20020,Q6P4Q7,P55011,P05023,Q9UM00,P35670,P16615,O95202 14 +Sphingolipid binding 0.8644732055856227 2.9768185584618982 0.0029125632402242 0.9819832159756766 0.1671083159078671 10 P07602,P45880,Q9NZJ7,Q9UM22,P21796 5 +Anion channel activity 0.8050057520044442 2.8779554418887665 0.0040026167050588 0.9960048060099136 0.220464128114642 12 P0CG08,Q9C0H2,P45880,Q9Y277,Q9NW15,P21796,Q4KMQ2,Q96S66,P51798,P51790 10 +Passive transmembrane transporter activity 0.625235768945837 2.8181203026669994 0.0048305706925566 0.9987288248776286 0.2361784607416951 34 P06576,P0CG08,P56385,P24539,Q96S66,Q9C0H2,P45880,Q9Y277,Q99797,Q9NW15,P21796,P39210,Q4KMQ2,O75964,O96008,Q9UM00,P51798,P51790 18 +Ceramide binding 0.9140008479981416 2.772102852058973 0.0055695435642419 0.9995429410872098 0.2361784607416951 7 Q9UM22,P21796,P07602,P45880 4 +Organic anion transmembrane transporter activity 0.6226692914552092 2.7202704095108894 0.0065228550869005 0.9998779882879524 0.2361784607416951 30 Q9HC21,O00400,Q14728,P05141,Q9H2D1,P53007,Q6NUK1,Q8TB61,Q6KCM7,Q9BQT8,P30825,P12236,Q9UJS0,Q9H9B4,O75746,Q9UBX3,O43808,P12235,Q9Y619 19 +Antiporter activity 0.7682029774037746 2.68709242009383 0.0072077006729078 0.9999527918901172 0.2361784607416951 12 P12236,Q9UBX3,P04920,P16260,P12235,P51798,P51790,O95202 8 +Macromolecule transmembrane transporter activity 0.7850606274085659 2.6783627609275125 0.007398304347197 0.9999637596339882 0.2361784607416951 11 O60830,O14925,P49755,Q9NS69,Q07820,O96008 6 +Alcohol binding 0.6764038986563173 2.6393659959768185 0.0083061253819274 0.9999897198954796 0.2361784607416951 18 O75477,Q9BZF3,P45880,P30536,O94905,P61916,P21796,Q53GS7,Q14108,O14735,O15118 11 +Sterol binding 0.6811876583277694 2.6116972989513916 0.0090093985476795 0.9999961296467736 0.2361784607416951 17 O75477,P45880,P30536,O94905,P61916,P21796,Q14108,O15118 8 +Metallopeptidase activity 0.578407323838704 2.610574088014784 0.009039039025424 0.9999962858154168 0.2361784607416951 40 Q969V3,Q6P179,P55786,Q99797,Q7Z2K6,Q10713,P22695,Q96TA2,Q92905,Q5JRX3,Q9UIQ6,P42892,P09960,P50579,O43847,O75844,Q9NZ08,Q7L5N1,P52888,O00303,P53582 21 +Protein transmembrane transporter activity 0.789090087419166 2.6078130506929 0.0091122706004187 0.99999664518807 0.2361784607416951 10 O60830,O14925,P49755,Q9NS69,Q07820,O96008 6 +Cholesterol binding 0.7127476076276277 2.5836891306395495 0.0097749856267461 0.9999986647252674 0.2361784607416951 14 O75477,P45880,P30536,O94905,P61916,P21796,Q14108,O15118 8 +Hydrolase activity acting on glycosyl bonds 0.605183846538721 2.5633044099714266 0.0103681099907322 0.9999994148603006 0.2361784607416951 28 Q16706,P16278,P17900,P35573,P06280,P54802,P10253,P04062,O75503,P06865,Q9BTY2,Q9NUJ1 12 +Snap receptor activity 0.7430201911503608 2.553836371152368 0.01065433126912 0.99999960710706 0.2361784607416951 12 Q86Y82,O15498,O60499,O15400,O75396,Q9P2W9,O95249,Q12981 8 +Carbohydrate derivative transmembrane transporter activity 0.7766103271924973 2.5450580108038405 0.0109259585230869 0.9999997308075482 0.2361784607416951 10 L0R6Q1,P12236,O00400,Q6NUK1,P05141,Q8TB61,P12235,Q6KCM7 8 +Metalloendopeptidase activity 0.7050614966434116 2.540204242483183 0.011078775067282 0.999999782400284 0.2361784607416951 14 O75844,Q5JRX3,P52888,P42892,O43847,Q99797,P14735,Q10713,Q96TA2,P22695,Q92905 11 +P type transmembrane transporter activity 0.8256909618713737 2.5326366387644694 0.0113208237885129 0.9999998446654882 0.2361784607416951 8 P98194,P20020,P05023,P16615,P35670,Q04656 6 +Exogenous protein binding 0.6784518697324635 2.4912947215299917 0.0127278492482516 0.9999999781428924 0.2361784607416951 15 Q14108,P11279,O15118,Q8WTV0 4 +Oxidoreduction driven active transmembrane transporter activity 0.5837809762345532 2.474321286615271 0.0133489588724278 0.9999999908114372 0.2361784607416951 32 Q9P0J0,P20674,O14548,P13073,O95168,Q7KZN9,P00403,O95299,O96000,Q9UDW1,P51970,Q9Y6M9,P03886,O43676,O95139 15 +Monooxygenase activity 0.7792906336625051 2.473861321085408 0.0133661569284282 0.9999999910293584 0.2361784607416951 9 Q6UW02,P09601,P30519,Q15800,Q16850 5 +Voltage gated anion channel activity 0.8449000379423046 2.4644665305501805 0.0137217378180536 0.999999994539176 0.2361784607416951 7 Q9Y277,P45880,P21796,P51798,P51790 5 +Nucleobase containing compound transmembrane transporter activity 0.6707936755804079 2.446067249895955 0.0144424058971173 0.9999999980041588 0.2361784607416951 15 Q9BSK2,L0R6Q1,P12236,O00400,Q6NUK1,Q8TB61,Q9H2D1,P12235,Q6KCM7 9 +Inorganic anion transmembrane transporter activity 0.6126938025551365 2.415133999580298 0.0157294217807677 0.9999999996698804 0.2373749589790648 21 P0CG08,O43681,Q9UBX3,Q9C0H2,P45880,Q9Y277,P04920,Q15043,Q9NW15,P21796,P55011,Q4KMQ2,Q96S66,P51798,P51790 15 +Transition metal ion transmembrane transporter activity 0.9023631840796008 2.3825993243315104 0.01719089377589 0.9999999999573372 0.2373749589790648 5 P35670,P98194,Q9HD20,Q15043 4 +Hexosyltransferase activity 0.5607701370568225 2.3779127578367616 0.0174109447036205 0.9999999999686572 0.2373749589790648 36 Q8N4A0,Q16739,Q8N6G5,Q9BT22,P35573,Q96L58,Q16880,P04062,P06865,Q10472,Q13126,P46977,Q2TAA5 13 +Molecular transducer activity 0.5613282955150541 2.3616834174092545 0.0181921702008234 0.9999999999895172 0.2447340681970669 35 Q8WTV0,Q14108,Q9BUN8,Q9Y6I9,Q08722,Q99442,P30536,Q5KU26,O75787,Q15375,Q99720,O15173,O15118,Q9UBG0 14 +Protein carrier chaperone 0.7877581991141648 2.352352902741259 0.01865506662524 0.999999999994524 0.2447863545825107 8 Q8N8Q8,Q9NPA0,P40855,Q15070 4 +Atpase coupled transmembrane transporter activity 0.571584327908822 2.321205746186412 0.0202757422122075 0.9999999999994376 0.2538154275109976 28 P06576,P20020,P05023,P16615,Q03519,P98194,Q9NRK6,P28288,P23634,P51798,P35670,Q04656,P61421,Q15388,P36543,Q03518,Q9HD20,Q9NP58,O75027,Q9NUT2 20 +Oxidoreductase activity acting on a heme group of donors 0.8099880083637722 2.304581607918097 0.0211900170103511 0.9999999999998446 0.2581174377308464 7 P16435,O14548,P13073,Q7KZN9,P00403 5 +Peptide binding 0.4440638064363427 2.298490304550371 0.0215338990763416 0.9999999999999042 0.2581174377308464 73 Q6P179,Q15392,Q99471,O14773,P40855,Q8WTV0,Q03519,Q9UIQ6,P24390,P04439,P42892,Q9H7Z7,Q9NQX7,Q7Z569,P52292,Q9NZ08,Q15388,Q8TEX9,Q03518,P10321,Q99735,O00264 22 +Proton transporting atp synthase activity rotational mechanism 0.724089978777291 2.2755526798361445 0.022872796282213 0.9999999999999856 0.2606893708236772 10 P06576,O75964,P24539 3 +Proton channel activity 0.724089978777291 2.2755526798361445 0.022872796282213 0.9999999999999856 0.2606893708236772 10 P06576,O75964,P24539 3 +Mhc protein binding 0.7390323224330086 2.2718319592091656 0.0230966617577985 0.9999999999999892 0.2606893708236772 9 P06576,Q03519,Q9BUN8,P51572,Q03518 5 +Membrane insertase activity 0.8741664408093647 2.264501709877043 0.0235432747102632 0.9999999999999944 0.2635698315124598 5 Q8N8Q8,Q9NPA0,Q15070 3 +Atpase coupled cation transmembrane transporter activity 0.6231921214385043 2.2549633734081964 0.0241356278689608 0.9999999999999976 0.2676662539441442 17 P06576,P98194,P61421,P36543,P23634,Q9HD20,P20020,P05023,P16615,P35670,Q04656 11 +O acyltransferase activity 0.654664217611681 2.249223718878869 0.0244982661503136 0.9999999999999986 0.2676662539441442 14 Q9HCL2,Q96N66,Q9NUQ2,P50416,O15228,Q6UWP7,P23786,Q92604,Q8NF37 9 +Mhc class i protein binding 0.7645779823762524 2.2402378160039103 0.0250754878422618 0.9999999999999992 0.2676662539441442 8 P06576,Q03519,P51572,Q9BUN8 4 +Calcium ion binding 0.4499439374632049 2.226332277379899 0.0259919329993216 0.9999999999999998 0.2691044491734282 84 O43681,P80303,P16615,P41208,O43852,Q6NUK1,Q9UM22,Q6KCM7,Q9BRK5,O95202,Q02818,P55327,P27824,Q9BPX6,Q99828,Q14257,Q8IXI1,Q9NWM8,Q9UJS0,Q96A33,O75071,Q9Y680,P67936,Q8NF37 24 +Glycolipid binding 0.6807131302702483 2.21449005223941 0.0267950862689057 1.0 0.2738618705078774 12 Q9UM22,P50897,P07602 3 +Atp transmembrane transporter activity 0.8080870917573763 2.1533484807773293 0.0312913012955315 1.0 0.2990493275531579 6 P12236,Q6NUK1,P05141,P12235,Q6KCM7 5 +Nucleotide transmembrane transporter activity 0.6527466211012614 2.1444861288826274 0.0319939556892607 1.0 0.2996984828851162 13 Q9BSK2,P12236,O00400,Q6NUK1,Q8TB61,Q9H2D1,P12235,Q6KCM7 8 +Organophosphate ester transmembrane transporter activity 0.6527466211012614 2.1444861288826274 0.0319939556892607 1.0 0.2996984828851162 13 Q9BSK2,P12236,O00400,Q6NUK1,Q8TB61,Q9H2D1,P12235,Q6KCM7 8 +Gated channel activity 0.6459349716137259 2.1050845084568786 0.0352839524849852 1.0 0.3154935231936671 13 Q9C0H2,Q9Y277,P45880,Q9NW15,P21796,P51798,P51790 7 +Solute cation symporter activity 0.761667703795902 2.0782550236179405 0.0376858765902936 1.0 0.3300762367325487 7 O00400,Q9Y289,Q15043,P55011,Q96ES6,Q00325 6 +Phosphatidylcholine binding 0.7006054869616417 2.0743634330501854 0.038045570698282 1.0 0.3300762367325487 9 P21796,P45880 2 +Glycosphingolipid binding 0.9343510998640352 2.0548289120899894 0.0398955326054906 1.0 0.3385216150832038 4 Q9UM22,P07602 2 +Peptide antigen binding 0.782235485557063 2.0360412408167474 0.041746214229609 1.0 0.3385216150832038 6 Q15392,Q03519,Q03518,P10321 4 +Oxidoreductase activity acting on nad p h 0.527776114869402 2.0339485859602067 0.0419567795418449 1.0 0.3385216150832038 31 Q9P0J0,P16435,O95831,O95168,Q7KZN9,O95299,O96000,P51970,Q9Y6M9,Q13423,P03886,O43676,O95139 13 +Endopeptidase activity 0.4298924145583354 2.029388421717945 0.0424187434755767 1.0 0.3385216150832038 61 Q4J6C6,Q6P179,Q96RU2,Q92542,Q99797,O14773,Q10713,P22695,Q96TA2,Q92905,Q92643,Q5JRX3,P53634,P42892,O43847,P14735,P67812,O75844,P04632,Q9NZ08,Q9UPU5,Q8TCT8,Q8TCT9,P49721,P52888,P28072,Q6NTF9 27 +Hexosaminidase activity 0.8159714732828147 2.0157174984886717 0.0438295247726725 1.0 0.3432316521296567 5 P54802,P17900 2 +Vitamin transmembrane transporter activity 0.7764440244788118 2.0095546446921984 0.0444783456786022 1.0 0.3435864419829909 6 P04062,P38435,Q9H2D1 3 +Cation channel activity 0.5692358774022602 2.0078075872618797 0.044663742276656 1.0 0.3435864419829909 19 P06576,P56385,P24539,Q9NW15,Q4KMQ2,O75964,Q9UM00 7 +Symporter activity 0.6845807155834601 1.9906732453960616 0.0465168219293632 1.0 0.3513488053517435 9 O00400,Q9Y289,P53985,Q15043,P55011,Q96ES6,Q00325 7 +Palmitoyltransferase activity 0.8093357942445641 1.9869237003606048 0.0469308527774887 1.0 0.3513488053517435 5 O15269,P50416,P23786 3 +Udp glycosyltransferase activity 0.5491810693060434 1.9802712618829357 0.047673056177768 1.0 0.3548421532799277 21 Q8N4A0,Q16739,Q8N6G5,Q8NBI6,Q96L58,Q16880,P06865,Q10472 8 +Acylglycerol o acyltransferase activity 0.7094052939401955 1.9673973604358408 0.0491374184236756 1.0 0.3618300811197937 8 Q8NF37,Q92604,Q96N66 3 +Lysophospholipid acyltransferase activity 0.7372326886524756 1.96158295290233 0.0498110585701301 1.0 0.3648395087822829 7 Q8NF37,Q92604,Q96N66 3 +Fad binding 0.6481426968164785 1.9479445796675825 0.0514215948251137 1.0 0.3668784252548273 11 O95831,Q15392,Q14534,O00116,O15254 5 +Prenyltransferase activity 0.7607413560044438 1.9373642502444 0.0527008334286609 1.0 0.3721093274321441 6 P37268,P14324,P49354,Q92696 4 +Threonine type peptidase activity 0.674041235252012 1.9352024880120111 0.0529654525611476 1.0 0.3721093274321441 9 P49721,Q9UJ14 2 +Amino acid transmembrane transporter activity 0.6574073337345956 1.9205247837444448 0.0547916457208317 1.0 0.3810509906948752 10 Q96H78,Q9UJS0,O75746,P30825,Q9Y619 5 +Glycosyltransferase activity 0.4658360653382821 1.910072928929684 0.0561238239851984 1.0 0.3883542996362726 49 Q8N4A0,Q16739,P43490,Q8N6G5,Q9BT22,P35573,Q96L58,Q16880,P04062,P06865,Q10472,Q13126,P04843,P46977,Q2TAA5 15 +Molecular carrier activity 0.5032019245085912 1.8854762219131391 0.059365571782326 1.0 0.3993169358573061 34 Q8N8Q8,Q8TEX9,Q15070,Q15006,Q9C0E2,Q9NPA0,O75880,O43819,P40855,Q04656 10 +Scavenger receptor activity 0.7809012226547865 1.8625796792675464 0.062521425525595 1.0 0.4102521570666285 5 Q14108,Q8WTV0 2 +Organic acid transmembrane transporter activity 0.5218284230400626 1.842770051209588 0.0653625912235729 1.0 0.4205807855834574 22 Q96H78,Q9Y289,Q9UJS0,Q9H9B4,O75746,Q9BQT8,Q9UBX3,Q9H2D1,P30825,P53007,Q9Y619 11 +Acetylgalactosaminyltransferase activity 0.7751822502428012 1.8373865657383055 0.0661528486418803 1.0 0.4236859189761358 5 Q8N6G5,Q10472 2 +Wide pore channel activity 0.8765064247950722 1.8230980103737748 0.0682885478955461 1.0 0.424824499319954 4 P21796,P45880 2 +Porin activity 0.8765064247950722 1.8230980103737748 0.0682885478955461 1.0 0.424824499319954 4 P21796,P45880 2 +Exopeptidase activity 0.4972401046517404 1.8221486389804364 0.0684324352765286 1.0 0.424824499319954 33 O75844,Q969V3,Q6P179,Q9HB40,P53634,Q9UIQ6,Q9NZ08,P09960,P55786,P42785,O14773,Q7Z2K6,Q8IYS1,P10619,Q9H3G5,P53582 16 +Cargo receptor activity 0.6787457179994026 1.8121774621733584 0.0699587803240477 1.0 0.4283228843538178 8 Q5KU26,Q14108,Q8WTV0 3 +Nadh dehydrogenase activity 0.5086484933827277 1.805253892786134 0.0710349610701013 1.0 0.4290137780417961 23 Q9P0J0,O95831,O95168,O95299,O96000,Q9Y6M9,P03886,O43676,O95139 9 +Calcium ion transmembrane transporter activity 0.5944121837786008 1.8012382353937506 0.0716653382405525 1.0 0.4302907544416039 13 P98194,P23634,P20020,Q9UM00,P16615,O95202 6 +Copper ion binding 0.6217755241236221 1.7999320523066071 0.0718713678442766 1.0 0.4302907544416039 11 P04637,P00403,O43819,P35670,Q04656 5 +Serine type carboxypeptidase activity 0.7609161799705999 1.7742815337111777 0.076016593508543 1.0 0.445424890473463 5 Q9HB40,P10619 2 +Misfolded protein binding 0.5756740819227786 1.7722319506069018 0.0763560619455345 1.0 0.4455182088940724 14 P48723,P46379,Q9BUN8,Q9GZP9,Q6NTF9 5 +Tap binding 0.7581450983552289 1.7619815036618256 0.0780724226106197 1.0 0.4479405247284308 5 Q03519,Q03518,P10321 3 +Sodium ion transmembrane transporter activity 0.7216968542763122 1.7555427051848094 0.0791665226506621 1.0 0.4511675502613694 6 P05023,Q6P4Q7,P55011,Q9Y289 4 +Sterol transporter activity 0.6396992555080905 1.7521427032339911 0.0797492729642879 1.0 0.4519125467976314 9 P61916,O15118 2 +Transferase activity transferring alkyl or aryl other than methyl groups 0.5156939250372378 1.7419980803926571 0.0815087801580165 1.0 0.4596639351096176 21 P49366,P37268,P52788,P49354,O00116,Q92696,P14324,Q99735 8 +Oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen 0.4892643058501338 1.7311464507096013 0.0834256473652708 1.0 0.4612048012638295 31 P16435,Q6UW02,P09601,P30519,Q9NVH6,Q14534,Q15800,Q16850 8 +L amino acid transmembrane transporter activity 0.6896664839092302 1.7303112276634718 0.0835746846277232 1.0 0.4612048012638295 7 P30825,O75746,Q9UJS0,Q9Y619 4 +Glucosidase activity 0.7501025456623283 1.7262067486134904 0.0843102243785811 1.0 0.4612048012638295 5 P10253,P04062 2 +Quaternary ammonium group binding 0.5662686686450729 1.7137464434592384 0.0865753032364009 1.0 0.4612048012638295 14 P21796,P45880 2 +Oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen reduced flavin or flavoprotein as one donor and incorporation of one atom of oxygen 0.9872631251941596 1.7108426148126807 0.0871101703964414 1.0 0.4612048012638295 2 P09601 1 +Metalloexopeptidase activity 0.5109088044546778 1.7074483057008258 0.0877387583656088 1.0 0.4612048012638295 21 O75844,Q969V3,Q6P179,Q9UIQ6,Q9NZ08,P09960,P55786,Q7Z2K6,P53582 9 +Phosphotransferase activity for other substituted phosphate groups 0.7454750209653659 1.7055721276163789 0.088087772499918 1.0 0.4612048012638295 5 Q5H8A4,Q9BVG9 2 +G protein beta gamma subunit complex binding 0.7061625273673171 1.6823221851029668 0.0925063814402213 1.0 0.4788770197112212 6 P50148,P41208,P04899 3 +Ganglioside binding 0.9664387818520797 1.6403357568034151 0.1009353748763817 1.0 0.4969410820102318 3 Q9UM22,P07602 2 +P type calcium transporter activity 0.8281007149518073 1.6258556230634034 0.1039803723382397 1.0 0.5095408281485984 4 P20020,P98194,P16615 3 +Phospholipase d activity 0.9645852749301006 1.618088283112591 0.1056435732331693 1.0 0.5142637609659609 2 P09601 1 +Lamin binding 0.6144169154263041 1.6151973772737032 0.106267958354788 1.0 0.5152499248399408 9 O94901,Q9ULX6,Q9UH99,Q5SNT2,Q14739,P42167 6 +Dicarboxylic acid transmembrane transporter activity 0.6631453310132522 1.5991170710084963 0.1097945922319658 1.0 0.5245003473684585 7 Q9BQT8,Q9UJS0,Q9UBX3 3 +Vitamin d binding 0.9586828207517852 1.593918796051386 0.1109542239459282 1.0 0.5255544966832254 2 P04062 1 +Hormone binding 0.6617936033364569 1.592390404381128 0.1112970109491973 1.0 0.5255544966832254 7 P05023,P42892,P30536,O43847 4 +Voltage gated channel activity 0.5970447909199612 1.5869599720513412 0.1125217106493545 1.0 0.5255544966832254 10 Q9Y277,P45880,P21796,P51798,P51790 5 +Oxidoreductase activity acting on a sulfur group of donors oxygen as acceptor 0.7179726368159156 1.5822118904800395 0.1136012068339815 1.0 0.5255544966832254 5 Q9UHG3,Q6ZRP7,P07237,Q96HE7 4 +Phospholipase binding 0.7172764208423776 1.5790737449381935 0.1143191430405328 1.0 0.5255544966832254 5 P20700 1 +Sulfotransferase activity 0.954954954954954 1.578649810028867 0.1144164028970808 1.0 0.5255544966832254 2 Q8NCH0 1 +Antigen binding 0.6332057562573123 1.5771355381283958 0.1147643415407404 1.0 0.5255544966832254 8 Q15392,Q03519,Q03518,P10321 4 +Phosphoric diester hydrolase activity 0.5949866529316324 1.5753957214697978 0.1151651313745858 1.0 0.5255544966832254 10 Q8IV08,P09601 2 +Malate dehydrogenase activity 0.7149074806756632 1.5683905463325971 0.1167900160166812 1.0 0.5255550720750657 5 O43175 1 +Acid phosphatase activity 0.7112307810600327 1.5517935549020492 0.1207116285943117 1.0 0.5302309081678716 5 P11117 1 +Palmitoyl protein hydrolase activity 0.810082564323666 1.551789939587029 0.1207124939270549 1.0 0.5302309081678716 4 P50897 1 +Serine type exopeptidase activity 0.6527238259639874 1.54716095387901 0.1218244387696485 1.0 0.5302309081678716 7 Q9HB40,O14773,Q9H3G5,P10619 4 +Phosphatidylserine binding 0.5895795798470369 1.5449587458119731 0.1223562423447812 1.0 0.5302309081678716 10 Q14108 1 +Lipid transporter activity 0.4884332160237559 1.5435440994661132 0.1226988162380635 1.0 0.5302309081678716 21 P28288,P17900,Q9BZF3,Q96AA3,P30536,P61916,Q4KMQ2,Q7Z3C6,O15118 9 +Adp transmembrane transporter activity 0.8075847062480533 1.541498748812422 0.123195447209653 1.0 0.5302309081678716 4 P12235,P05141,P12236 3 +Pattern recognition receptor activity 0.9453246349798068 1.5391948471620314 0.1237567352172703 1.0 0.5302309081678716 2 Q8WTV0 1 +Solute anion antiporter activity 0.675874773263851 1.5382394073222707 0.123990088910715 1.0 0.5302309081678716 6 P12235,P12236,P04920 3 +Protease binding 0.4658595733791295 1.5317185619063785 0.1255918998736762 1.0 0.53049093903697 30 P07602,P46379,P04637,Q9NZJ7,Q6NTF9,O75955,P54725,Q9GZP9 8 +Oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen nad p h as one donor and incorporation of one atom of oxygen 0.9366065879428158 1.525672208957396 0.1270915190074091 1.0 0.5319301570614053 3 Q16850,Q15800 2 +Glucosyltransferase activity 0.5850281692856338 1.5192769281700027 0.1286928046428341 1.0 0.5337650361240441 10 Q16739 1 +Solute proton antiporter activity 0.9316557937247556 1.4831856995812835 0.1380250795744462 1.0 0.557963551420009 2 O95202 1 +Mannosyltransferase activity 0.6952184354966688 1.479293666723394 0.1390618448024425 1.0 0.557963551420009 5 Q9BT22 1 +Oxidoreductase activity acting on nad p h quinone or similar compound as acceptor 0.463626306649451 1.4734020121819855 0.14064266803874 1.0 0.5596190418049849 25 Q9P0J0,O95168,O95299,O96000,P51970,Q9Y6M9,P03886,O43676,O95139 9 +Beta n acetylhexosaminidase activity 0.7903031313005063 1.470161054404415 0.1415181397960845 1.0 0.5599726393655413 4 P17900 1 +Organic cation transmembrane transporter activity 0.7840750299605048 1.4443990114802354 0.1486267686370093 1.0 0.5690213637787465 4 Q70HW3,Q9HC21 2 +L ornithine transmembrane transporter activity 0.921404162783469 1.441189143676092 0.1495312545852543 1.0 0.5690213637787465 2 P30825 1 +Amyloid beta binding 0.5588182695359509 1.4375074455643864 0.1505738587471472 1.0 0.5690213637787465 11 Q9NQX7,O00264,Q99471,Q8WTV0 4 +Structural constituent of eye lens 0.9131794356022092 1.435398355052128 0.151173614488 1.0 0.5690213637787465 3 P08670 1 +Nadp binding 0.4860558645408477 1.431384565724226 0.15232002937188 1.0 0.5696826364604844 19 P16435,P48163,P04035,Q08257,Q13423,P11413,Q9UBM7,Q14739 8 +Manganese ion transmembrane transporter activity 0.9101926662523284 1.4238814850915262 0.1544807823071314 1.0 0.5696826364604844 3 Q9HD20,Q15043 2 +Serine hydrolase activity 0.4846833744182402 1.4216002568236137 0.1551423301907637 1.0 0.5696826364604844 19 P67812,Q4J6C6,Q9HB40,Q5JRX3,Q6PIU2,P42785,O14773,P10619,Q9H3G5,Q6NTF9 10 +O methyltransferase activity 0.6269521877568741 1.4177996015957184 0.156249280532547 1.0 0.5722214342907375 7 O60725 1 +Growth factor receptor binding 0.5057569851636309 1.4098755730599457 0.1585764265443734 1.0 0.5781945731586712 15 P05067,O60749,Q92542 3 +Protein geranylgeranyltransferase activity 0.9136377757067392 1.4093893247637457 0.1587200789063019 1.0 0.5781945731586712 2 P49354 1 +Purine nucleotide transmembrane transporter activity 0.5644184925663369 1.4023200288895905 0.1608197020554735 1.0 0.5819685017357635 10 P12236,O00400,Q6NUK1,P05141,Q8TB61,P12235,Q6KCM7 7 +Thiolester hydrolase activity 0.5290350487332138 1.4016360217574082 0.1610239645325533 1.0 0.5819685017357635 13 P50897 1 +Dolichyl diphosphooligosaccharide protein glycotransferase activity 0.7730389944288397 1.398692560245458 0.1619051961779205 1.0 0.5836216103062738 4 P46977 1 +Threonine type endopeptidase activity 0.5976649398958274 1.390392949902117 0.1644095861434893 1.0 0.5886735780464112 8 P49721 1 +Galactosidase activity 0.9064926995961478 1.3801519222376983 0.1675398733968285 1.0 0.5886735780464112 2 P16278 1 +Galactoside binding 0.9064926995961478 1.3801519222376983 0.1675398733968285 1.0 0.5886735780464112 2 P16278 1 +Mannose binding 0.6426909167437407 1.3786287918371414 0.1680092346929844 1.0 0.5886735780464112 6 O75503 1 +Guanylate kinase activity 0.6703477632532933 1.3660644915217102 0.1719187221852274 1.0 0.590740330301688 5 Q14168,Q12959 2 +C4 dicarboxylate transmembrane transporter activity 0.6691940551880351 1.3607963131549337 0.1735780673599303 1.0 0.590740330301688 5 Q9UBX3,Q9UJS0 2 +Sulfur compound transmembrane transporter activity 0.5919148519844278 1.3599498242134591 0.1738458025425435 1.0 0.590740330301688 8 Q70HW3,O00400,Q8TB61,Q9UBX3 4 +Copper ion transmembrane transporter activity 0.9015222118670334 1.3598263227276226 0.1738848904852505 1.0 0.590740330301688 2 P35670 1 +Procollagen proline dioxygenase activity 0.7634442026732997 1.35890668169063 0.1741761612944701 1.0 0.590740330301688 4 O15460,P13674,P07237 3 +Peptidyl proline dioxygenase activity 0.7634442026732997 1.35890668169063 0.1741761612944701 1.0 0.590740330301688 4 O15460,P13674,P07237 3 +Potassium ion transmembrane transporter activity 0.7484401007885485 1.296628999104279 0.1947588696163662 1.0 0.6202720058568826 4 P05023,P55011 2 +Intramembrane lipid transporter activity 0.7477363587737369 1.2937067939868845 0.195766717709205 1.0 0.6202720058568826 4 Q96AA3,Q7Z3C6 2 +Iron ion binding 0.4408012149108778 1.2849764476542664 0.1988005144473759 1.0 0.6202720058568826 23 P22830,Q6UW02,P31350,P13674,Q9NVH6,Q15800,O15460,Q16850 8 +2 acylglycerol 3 phosphate o acyltransferase activity 0.8722809198259799 1.2777277570054322 0.2013454346626435 1.0 0.6202720058568826 3 Q96N66,Q8NF37 2 +Protein prenyltransferase activity 0.8713019621768283 1.2739579073608007 0.202678334198602 1.0 0.6202720058568826 3 P49354 1 +Azole transmembrane transporter activity 0.8800869835352522 1.2723510032747414 0.2032484344696505 1.0 0.6202720058568826 2 P30825 1 +Cytoskeleton nuclear membrane anchor activity 0.7425677009631247 1.2722429448797636 0.2032868134770489 1.0 0.6202720058568826 4 Q8WXH0,Q9UH99 2 +Aspartic type peptidase activity 0.7415710637507957 1.2681040033850366 0.2047608120645594 1.0 0.6202720058568826 4 Q8TCT8,Q92542 2 +G protein alpha subunit binding 0.8669277542941994 1.2571182097576183 0.2087108341958377 1.0 0.6202720058568826 3 P80303 1 +Solute cation antiporter activity 0.8623388404870582 1.2394614975752054 0.2151746390027886 1.0 0.6317600808248187 3 O95202 1 +Nadph binding 0.5891920472335693 1.2264338753598902 0.2200354447509531 1.0 0.6405683032178912 7 P04035,Q14739,Q08257 3 +Oxidoreductase activity acting on a sulfur group of donors 0.4301812435314165 1.2085949694568574 0.2268184900163157 1.0 0.6444490183766272 25 Q96JJ7,Q8IXB1,Q96HE7,Q9Y320,Q9H3N1,P09622,O43819,Q9UHG3,Q6ZRP7 9 +Carnitine o acyltransferase activity 0.8642435538987245 1.207957361603152 0.2270636635974381 1.0 0.6444490183766272 2 P23786 1 +O palmitoyltransferase activity 0.8642435538987245 1.207957361603152 0.2270636635974381 1.0 0.6444490183766272 2 P23786 1 +Phospholipid transporter activity 0.5589267646869649 1.1843553708223915 0.2362724187910059 1.0 0.6585974102737149 8 Q9NZD2,P08183,Q4KMQ2,Q7Z3C6 4 +Tap1 binding 0.8570984777881325 1.1790141223922466 0.2383925524055237 1.0 0.6591111616382338 2 Q03519 1 +Quinone binding 0.7182262380045947 1.171183540507869 0.2415250098124528 1.0 0.6616864970768486 4 P21912,Q16134 2 +Thiol oxidase activity 0.7177494560149154 1.169205522743067 0.2423208366170313 1.0 0.6620551429001034 4 Q6ZRP7,P07237,Q96HE7 3 +Sterol transfer activity 0.842268555568709 1.1623902393384131 0.245076986241953 1.0 0.6669387550497419 3 P61916 1 +Ubiquitin specific protease binding 0.5195750548514116 1.1447623214636056 0.2523076273119584 1.0 0.6759291883435151 10 P54725,Q6NTF9,Q9GZP9,P46379 4 +Metal dependent deubiquitinase activity 0.5713351277447424 1.1354437016940593 0.2561894578014732 1.0 0.6768286706934649 7 Q92905,Q7L5N1 2 +Voltage gated chloride channel activity 0.8349906774393904 1.134522181987453 0.2565755745112332 1.0 0.6768286706934649 3 P51798,P51790 2 +Intracellular calcium activated chloride channel activity 0.8349906774393812 1.1345221819874174 0.2565755745112481 1.0 0.6768286706934649 3 Q9NW15,Q9C0H2 2 +Ion gated channel activity 0.8349906774393812 1.1345221819874174 0.2565755745112481 1.0 0.6768286706934649 3 Q9NW15,Q9C0H2 2 +Volume sensitive anion channel activity 0.8331261653200522 1.1273909983998898 0.2595772032549583 1.0 0.6799131087828976 3 Q9C0H2,P51790 2 +Protein lipid complex binding 0.7066322966403276 1.123115153282609 0.2613885912126985 1.0 0.6804009264648126 4 Q8WTV0 1 +Oxidoreductase activity acting on diphenols and related substances as donors 0.7044609602296399 1.1141214751232769 0.2652270768811935 1.0 0.6826498782530905 4 Q9UDW1 1 +Ubiquinol cytochrome c reductase activity 0.7044609602296399 1.1141214751232769 0.2652270768811935 1.0 0.6826498782530905 4 Q9UDW1 1 +Syntaxin binding 0.4306456078054826 1.1112331207401889 0.2664680182596526 1.0 0.6829590008656169 21 Q9BVK6,O60499,P49755,O15400,Q9UNK0,Q99747 6 +Metalloaminopeptidase activity 0.4826301272397471 1.1103804776123989 0.2668351070920129 1.0 0.6829590008656169 13 Q6P179,Q9UIQ6,Q9NZ08,P09960,P55786,P53582 6 +Nucleobase transmembrane transporter activity 0.8378378378378348 1.1013734395300423 0.2707341603065241 1.0 0.6873766261991399 2 P12235 1 +Oxidative phosphorylation uncoupler activity 0.8378378378378348 1.1013734395300423 0.2707341603065241 1.0 0.6873766261991399 2 P12235 1 +Modified amino acid binding 0.4292491527590862 1.1006316293926404 0.27105701381709 1.0 0.6873766261991399 21 Q14108,Q9H7Z7,Q8WTV0 3 +Oligosaccharyl transferase activity 0.6116572068354658 1.097096729898006 0.2725991095860296 1.0 0.6889940907987079 5 P46977 1 +Cullin family protein binding 0.6106398892529263 1.0924296636221416 0.2746442905302153 1.0 0.6902322742609175 5 O60826,Q9BTE7 2 +Lysophosphatidic acid binding 0.8353525939732719 1.0914019606487062 0.275096050073023 1.0 0.6902322742609175 2 P50897 1 +Phospholipid scramblase activity 0.8347312830071408 1.0889109402621298 0.2761931613055637 1.0 0.6902322742609175 2 Q7Z3C6 1 +Calcium activated cation channel activity 0.8347312830071391 1.0889109402621229 0.2761931613055668 1.0 0.6902322742609175 2 Q9NW15 1 +Mhc class ib protein binding 0.8219390926040975 1.0846846344133696 0.2780613556189668 1.0 0.6923878601940638 3 Q03519,Q03518 2 +Lipid transfer activity 0.5394651398823321 1.0802623589098894 0.2800253664706718 1.0 0.6937578076788283 8 P61916,Q9NZD2,P30536 3 +Mannosidase activity 0.8306927617272439 1.0727379328858244 0.2833887156997887 1.0 0.6956172071249289 2 Q16706 1 +Carboxypeptidase activity 0.4850623280568643 1.0618757763431608 0.2882920833367077 1.0 0.7010112584093936 12 Q9HB40,P10619 2 +Aspartic endopeptidase activity intramembrane cleaving 0.8151025481665475 1.0586627516750569 0.2897533972949129 1.0 0.7010112584093936 3 Q8TCT8,Q92542 2 +3 hydroxyacyl coa dehydrogenase activity 0.5740286332342488 1.0448921953228727 0.2960727973455181 1.0 0.7064719758476234 6 P40939,Q16836 2 +Low density lipoprotein particle binding 0.8084045421938837 1.033232400431699 0.3014951536258365 1.0 0.7096732077654307 3 Q8WTV0 1 +Nadplus binding 0.684496303400175 1.0316135096909258 0.3022532090798215 1.0 0.7102434622916626 4 P40939 1 +Ubiquinone binding 0.8195091643367489 1.0281319208206252 0.3038877770560024 1.0 0.7108182510204613 2 P21912 1 +Isopeptidase activity 0.5281677355592402 1.0197850416372527 0.3078304189141465 1.0 0.7108182510204613 8 Q92905,Q7L5N1 2 +Heparin binding 0.4880927996348657 1.018866039311802 0.3082665683915886 1.0 0.7108182510204613 11 P05067,O14737 2 +Polypeptide n acetylgalactosaminyltransferase activity 0.6800142022909317 1.0131485575990289 0.3109892076474065 1.0 0.7108182510204613 4 Q10472 1 +Oxidoreductase activity acting on nad p h heme protein as acceptor 0.6761910674362519 0.997419227424483 0.3185610622996471 1.0 0.7120911539652645 4 Q7KZN9 1 +Nucleoside monophosphate kinase activity 0.4726518545393436 0.9856225991393271 0.3243183440258319 1.0 0.7156832687877733 12 Q14168,Q9UIJ7 2 +Carbohydrate binding 0.3696489650615239 0.976230327667075 0.3289503374122322 1.0 0.7189914517724505 49 P52789,Q6PK18,Q9UBG0,O00754,Q8N4A0,P13674,Q5KU26,Q9NPA0,O15460,Q00796,P35573,P27824,O75503,Q16706,P10253,Q10472,P11413,P35613,Q32P28 19 +Sphingosine n acyltransferase activity 0.8045977011494139 0.969126684083335 0.3324819854540224 1.0 0.7234515722801796 2 Q96G23 1 +O acetyltransferase activity 0.8042870456663472 0.9679037425660753 0.3330924450440333 1.0 0.7234515722801796 2 Q8NF37 1 +Heme transmembrane transporter activity 0.7895476094668927 0.962039361151676 0.3360298323259711 1.0 0.7286820143509642 3 O15173 1 +Steroid dehydrogenase activity 0.5157590383883075 0.953400504743294 0.3403871857878149 1.0 0.7326438171530423 8 Q3SXM5,Q8NBQ5,P51659,Q53GQ0 4 +Arylsulfatase activity 0.8002485243864466 0.9520308185662778 0.3410813523944322 1.0 0.7326438171530423 2 O43681 1 +Solute sodium symporter activity 0.7999378689033845 0.9508118060842768 0.3416999183064484 1.0 0.7326438171530423 2 P55011 1 +Solute proton symporter activity 0.7863404096188007 0.949997995401848 0.3421132711905637 1.0 0.7326438171530423 3 O00400 1 +Phosphatidylinositol 4 5 bisphosphate phosphatase activity 0.7821628340584208 0.934346147086521 0.3501253672581503 1.0 0.7417271241761209 3 Q96PE3,Q10713 2 +Inositol trisphosphate phosphatase activity 0.7821628340584208 0.934346147086521 0.3501253672581503 1.0 0.7417271241761209 3 Q96PE3,Q10713 2 +Phosphatidylinositol phosphate 4 phosphatase activity 0.782162834058419 0.9343461470865132 0.3501253672581543 1.0 0.7417271241761209 3 Q9NTJ5,Q96PE3 2 +Catalytic activity acting on a glycoprotein 0.7924821373097222 0.921644229990482 0.3567141796173156 1.0 0.747633828513004 2 Q96L58 1 +Beta 1 3 galactosyltransferase activity 0.7924821373097222 0.921644229990482 0.3567141796173156 1.0 0.747633828513004 2 Q96L58 1 +Udp galactose beta n acetylglucosamine beta 1 3 galactosyltransferase activity 0.7924821373097222 0.921644229990482 0.3567141796173156 1.0 0.747633828513004 2 Q96L58 1 +Protein phosphatase 2a binding 0.4804338611923862 0.918253576955482 0.3584861251603088 1.0 0.74997188330419 10 Q9P2B4,P04637,Q86XL3,Q15257,Q9UPR3 5 +Abc type transporter activity 0.4802909121933492 0.9174268546071638 0.3589190058805092 1.0 0.74997188330419 10 Q03519,Q9NRK6,P28288,Q03518,Q9HD20,Q9NP58,Q9NUT2 7 +Lipase activity 0.4083992714097258 0.9035427504810124 0.3662379098335968 1.0 0.7549544937737467 20 Q9Y6Y8,P09601,Q8N2A8,Q8NHP8,Q6PIU2,Q9H6V9,Q8IV08,Q8NCG7 8 +Chloride channel inhibitor activity 0.7862690276483297 0.897474816845118 0.369465605437306 1.0 0.7582028892506265 2 O15400 1 +Fk506 binding 0.5426020632700336 0.8922951336164616 0.3722347619530612 1.0 0.7594473337607249 6 Q9Y680,Q96AY3 2 +Macrolide binding 0.5426020632700336 0.8922951336164616 0.3722347619530612 1.0 0.7594473337607249 6 Q9Y680,Q96AY3 2 +Peptide hormone binding 0.7837837837837711 0.8878439402505703 0.3746247032838963 1.0 0.7594473337607249 2 P42892 1 +Sulfuric ester hydrolase activity 0.7678682411435678 0.8810962999044547 0.3782656997663109 1.0 0.7594473337607249 3 P34059,O43681 2 +Inositol polyphosphate 5 phosphatase activity 0.7819198508853584 0.8806351298669569 0.3785153381140393 1.0 0.7594473337607249 2 Q10713 1 +Phosphatidylinositol 4 5 bisphosphate 5 phosphatase activity 0.7819198508853584 0.8806351298669569 0.3785153381140393 1.0 0.7594473337607249 2 Q10713 1 +Procollagen proline 4 dioxygenase activity 0.7675574891236727 0.8799443722027991 0.3788894454231997 1.0 0.7594473337607249 3 O15460,P13674 2 +Peptidyl proline 4 dioxygenase activity 0.7675574891236727 0.8799443722027991 0.3788894454231997 1.0 0.7594473337607249 3 O15460,P13674 2 +Structural constituent of postsynapse 0.5638965962419791 0.87891400345588 0.3794479053212627 1.0 0.7594473337607249 5 Q16352,P07196 2 +Inositol phosphate phosphatase activity 0.6419511743838244 0.8576848745990362 0.3910664942591806 1.0 0.7729864190910506 4 Q96PE3,Q10713 2 +Anion cation symporter activity 0.7607209446861328 0.854668264926117 0.3927348239866473 1.0 0.7729864190910506 3 P55011,Q15043 2 +Apolipoprotein binding 0.6399889830487946 0.8497547621018866 0.3954614453140632 1.0 0.7746094028413444 4 Q8WTV0 1 +Cardiolipin binding 0.7698042870456585 0.8340948965981069 0.4042275107359019 1.0 0.7795246944241104 2 O60313 1 +17 beta hydroxysteroid dehydrogenase nadpplus activity 0.7548703178383267 0.8331429850388374 0.4047640933284233 1.0 0.7795246944241104 3 Q53GQ0 1 +Endopeptidase activator activity 0.5526961186866285 0.8282569484352763 0.4075249984981584 1.0 0.7807051654879286 5 P61289 1 +Peptidase activity 0.3580006560039656 0.8238399228985777 0.410030519992282 1.0 0.7809294965828111 112 Q969V3,Q4J6C6,Q6P179,Q96RU2,Q92542,P55786,Q99797,O14773,Q7Z2K6,Q10713,P10619,P22695,Q96TA2,Q92905,Q15005,Q92643,Q5JRX3,P53634,Q9UIQ6,P42892,P09960,Q9UJ14,Q8IYS1,P50579,O43847,O75844,P67812,P04632,Q9NZ08,Q9UPU5,P42785,Q8TCT8,Q8TCT9,P49721,Q7L5N1,Q9HB40,P52888,P28072,O00303,Q6NTF9,Q9BT78,Q9H3G5,P53582 43 +Arylesterase activity 0.7648337993165479 0.8151707111508771 0.414974600510487 1.0 0.7870799241087337 2 Q15165 1 +Copper chaperone activity 0.6307574534203033 0.8125873526775845 0.4164546851876369 1.0 0.7877171723947474 4 O43819,Q04656 2 +Metallochaperone activity 0.6307574534203033 0.8125873526775845 0.4164546851876369 1.0 0.7877171723947474 4 O43819,Q04656 2 +Glycosaminoglycan binding 0.4089414693687552 0.8106768064950777 0.417551296105185 1.0 0.7887080037542384 17 O14737,Q53GQ0,P05067 3 +Alpha glucosidase activity 0.7470263180170708 0.8044484653684918 0.4211380206579136 1.0 0.7896487488595487 3 P10253 1 +C acyltransferase activity 0.4511401728645328 0.7989171000236838 0.4243384828444556 1.0 0.7896487488595487 11 P40939 1 +Potassium chloride symporter activity 0.7604846225535835 0.7986985477140612 0.4244652290957045 1.0 0.7896487488595487 2 P55011 1 +Cation chloride symporter activity 0.7604846225535835 0.7986985477140612 0.4244652290957045 1.0 0.7896487488595487 2 P55011 1 +Proteasome binding 0.4499756263431077 0.7920173719873125 0.428350546968141 1.0 0.7896487488595487 11 P54725,O76024 2 +Galactosyltransferase activity 0.5445814245345532 0.7917527589246108 0.428504852758611 1.0 0.7896487488595487 5 Q16880,Q96L58 2 +Signal sequence binding 0.377293060897983 0.7890343827783453 0.430091911143545 1.0 0.7896487488595487 28 Q7Z569,P52292,P24390,Q8TEX9,P40855 5 +Dynein light intermediate chain binding 0.5012155294010134 0.7791600676628386 0.4358854297216732 1.0 0.7939341755644761 7 Q96ED9 1 +Cdp alcohol phosphatidyltransferase activity 0.7527182354768451 0.7694957693891233 0.4415990550538793 1.0 0.8022188638643692 2 Q9BVG9 1 +Nadp retinol dehydrogenase activity 0.5157242783465028 0.7631155305891217 0.4453944986693914 1.0 0.805544704145226 6 Q8NBN7 1 +Sphingolipid transporter activity 0.615769667726888 0.7528054813936343 0.4515668124225631 1.0 0.8138841632275777 4 Q9NZD2,P08183 2 +Amide transmembrane transporter activity 0.4944886627465411 0.7454372813008414 0.4560074132478413 1.0 0.8146117072624235 7 Q03519,O00400,Q9H2D1 3 +Structural constituent of synapse 0.4925736860753983 0.7358645847491236 0.4618131118830504 1.0 0.815131066929305 7 Q16352,P07196 2 +Nitric oxide synthase binding 0.7325256290773473 0.6949699179305693 0.4870741538780188 1.0 0.8381020956332121 2 P23634 1 +Atpase binding 0.3646454178563719 0.6911865384802952 0.4894483223684958 1.0 0.8381020956332121 30 Q8IXB1,Q93050,Q9BUN8,Q9NWS0,Q92542,Q9Y487,Q04323,P40855,P54709,O76024 10 +S methyltransferase activity 0.7152665078478724 0.6905214570528136 0.4898663211406568 1.0 0.8381020956332121 3 Q6UX53 1 +Branched chain amino acid transmembrane transporter activity 0.7284871077974393 0.6803310107873146 0.4962948931620965 1.0 0.8381020956332121 2 Q96H78 1 +Collagen binding 0.4463160027150559 0.6783435566995445 0.4975538877457768 1.0 0.8381020956332121 9 Q92791,Q32P28,Q53GQ0,Q9UBG0 4 +Gpi anchor binding 0.7115788461085473 0.6775622134869153 0.4980493113102611 1.0 0.8381020956332121 3 Q92643 1 +Oxidoreductase activity acting on the ch ch group of donors nad or nadp as acceptor 0.4221774140365517 0.6769545169837997 0.4984348126919775 1.0 0.8381020956332121 12 Q15392,Q8N4Q0,Q9H7Z7,Q9NZ01,Q14739 5 +Protein disulfide isomerase activity 0.443404950662599 0.6623281871876898 0.5077609159997514 1.0 0.8459605194161082 9 Q96JJ7,Q6ZRP7,Q92643 3 +Ceramide 1 phosphate transfer activity 0.7210313762037873 0.653559619113609 0.5133955672647272 1.0 0.8486743050702633 2 Q9NZD2 1 +Ceramide 1 phosphate binding 0.7210313762037873 0.653559619113609 0.5133955672647272 1.0 0.8486743050702633 2 Q9NZD2 1 +Glutathione peroxidase activity 0.4908273982325605 0.6455310096363622 0.5185831295070913 1.0 0.852134808271199 6 Q99735 1 +Mdm2 mdm4 family protein binding 0.4900001432068005 0.6416706529636831 0.5210870478700615 1.0 0.8545848692637353 6 P61289 1 +Structural constituent of muscle 0.5067903050966565 0.624822190645859 0.5320877647612656 1.0 0.8622947610862031 5 Q12797,P67936,P60660 3 +Oxidoreductase activity acting on the ch ch group of donors 0.3569813079253183 0.6238774545069864 0.5327080676844917 1.0 0.8622947610862031 29 Q8N4Q0,Q15392,Q7KZN9,Q9H7Z7,O15254,Q9NZ01,Q9UBM7,P21912,Q14739 9 +Dynein light chain binding 0.7104690897794337 0.6162320985960198 0.5377413462713649 1.0 0.8647966622904886 2 Q13409 1 +Phosphatidylinositol phosphate phosphatase activity 0.4517197756824734 0.6155049415798554 0.538221306886673 1.0 0.8647966622904886 8 Q9NTJ5,Q96PE3,Q10713 3 +Phospholipase activity 0.3833922311384136 0.6096606898792652 0.5420865998108018 1.0 0.8679688929528768 16 Q9Y6Y8,Q8IV08,P09601,Q8N2A8 4 +Oligopeptide binding 0.5723883834355257 0.5849877178284931 0.558555975309444 1.0 0.8804100396733812 4 Q9H7Z7 1 +Oxidoreductase activity acting on paired donors with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water 0.7002174588381413 0.5807236346669328 0.5614267300394102 1.0 0.8819010254664492 2 O00767 1 +Protein self association 0.3956953577796789 0.5636276626801744 0.573007556615474 1.0 0.8825854647198073 13 Q9Y282,P53634,P28288,P04637,O43765 5 +Nuclear import signal receptor activity 0.3875612460434957 0.5623025016240719 0.5739099341979523 1.0 0.8827143626270084 14 P52292,Q92973,Q8TEX9,O60518,Q96P70 5 +Ionotropic glutamate receptor binding 0.4916178455800797 0.5597420314262845 0.575655408597715 1.0 0.8827143626270084 5 P27824 1 +Glycolipid mannosyltransferase activity 0.6933830382106143 0.5574734249808803 0.5772040111500121 1.0 0.8831221370595185 2 Q2TAA5 1 +Glutathione transferase activity 0.4673402849683836 0.5374313676903947 0.5909696809036205 1.0 0.893265917238513 6 Q9Y2Q3,P78417,Q99735,O14880 4 +Lipid binding 0.3595588033865102 0.5326335830568302 0.5942872501651861 1.0 0.8942938520126752 141 O60313,P38435,P30536,P05023,O15173,Q9Y5X3,Q8WTV0,P50897,P07602,P45880,Q9UM22,P21796,O60749,O15118,Q99623,Q9Y371,P04062,P61916,Q9BWH2,O75208,Q14108,Q92543,Q96L92,Q9NZJ7,O00264,O15254 26 +Chaperone binding 0.3371055097525388 0.5304185482104559 0.5958217686740503 1.0 0.8942938520126752 41 P53634,Q8IXB1,Q96KC8,Q14108,Q9UNE7,P04637,O95433,O43808,O43615,P55011,P05023,Q7L5D6,Q16543,Q04656 14 +Nedd8 specific protease activity 0.6640051479217202 0.516771731001367 0.6053155159720514 1.0 0.899827030260782 3 Q9BT78 1 +Mitogen activated protein kinase kinase binding 0.6809568188878431 0.5161267167309473 0.6057659092605265 1.0 0.899827030260782 2 Q12959 1 +Signal recognition particle binding 0.4583242619196722 0.4968974709204323 0.6192613550833737 1.0 0.9054558753446408 6 Q9GZP9 1 +Dynactin binding 0.4431085098490258 0.4947674307118724 0.6207642969802851 1.0 0.9054558753446408 7 Q9Y5X3,Q8TD16 2 +Sodium channel regulator activity 0.5476949027774725 0.4941514602215032 0.6211992172041896 1.0 0.9054558753446408 4 Q96PU5 1 +Aminopeptidase activity 0.3644924866684603 0.4831863675053763 0.6289634140429574 1.0 0.9073988529007772 16 Q6P179,Q9UIQ6,Q9NZ08,P09960,P55786,P53582 6 +Peptidase activator activity 0.3952559875569714 0.4744762830221241 0.6351603067021758 1.0 0.9073988529007772 11 Q9UL46,P05067,P61289 3 +Lipase binding 0.6672879776327948 0.4721293350391422 0.6368344749076251 1.0 0.9073988529007772 2 Q96CS3 1 +Glutamate receptor binding 0.4365044816615041 0.4638086696697256 0.6427848313539519 1.0 0.9106751769902436 7 P27824,O75955 2 +Phospholipid binding 0.3088865441354224 0.4628235018242637 0.6434908839589739 1.0 0.9106751769902436 92 O60313,P50897,P07602,P45880,Q9NZJ7,Q9UM22,P21796,Q9BWH2,Q9Y5X3,Q14108,Q92543,O60749,Q96L92,Q8WTV0 14 +Disulfide oxidoreductase activity 0.3404459074099548 0.4567442421486425 0.6478548869493843 1.0 0.9139231098932612 22 Q96JJ7,Q8IXB1,Q96HE7,Q9Y320,Q9H3N1,O43819,Q6ZRP7 7 +Transferase activity transferring sulphur containing groups 0.3915769284461633 0.4538602568814996 0.6499294102950495 1.0 0.9141499468603504 11 Q7LGA3,Q8NCH0 2 +Sulfatide binding 0.6431911573600373 0.4509249535820659 0.652043638041149 1.0 0.914271785115194 3 P50897 1 +Phosphate ion binding 0.4621995522762825 0.4380622929452755 0.6613411275181025 1.0 0.9175886182981984 5 Q8NCH0 1 +G protein beta subunit binding 0.6385819020185027 0.4367811349145614 0.6622700816589009 1.0 0.9175886182981984 3 P63218 1 +L aspartate transmembrane transporter activity 0.6368290655706241 0.4314465753308972 0.6661436905192142 1.0 0.9182652467341416 3 Q9UJS0 1 +Acidic amino acid transmembrane transporter activity 0.6368290655706241 0.4314465753308972 0.6661436905192142 1.0 0.9182652467341416 3 Q9UJS0 1 +Scaffold protein binding 0.341743021481674 0.4120711521333349 0.680287272285192 1.0 0.9259476076306704 20 P07602,Q9NZJ7 2 +Phosphatidylinositol trisphosphate phosphatase activity 0.6251582093025853 0.3965707971891391 0.6916839908759749 1.0 0.9334808624777572 3 Q10713 1 +Phosphatidylinositol phosphate 5 phosphatase activity 0.6251582093025853 0.3965707971891391 0.6916839908759749 1.0 0.9334808624777572 3 Q10713 1 +Phosphatidylinositol 3 4 5 trisphosphate 5 phosphatase activity 0.6251582093025853 0.3965707971891391 0.6916839908759749 1.0 0.9334808624777572 3 Q10713 1 +Phosphatidylinositol bisphosphate phosphatase activity 0.4352129476860299 0.3960960004296027 0.6920342087281866 1.0 0.9334808624777572 6 Q96PE3,Q10713 2 +Amide binding 0.3183588314831669 0.3922752303865695 0.6948548632787874 1.0 0.9334808624777572 108 Q6P179,Q15392,Q99471,O14773,P40855,P40939,Q5T8D3,Q8WTV0,Q03519,P07602,Q9UIQ6,P24390,P04439,P42892,P45880,Q9UM22,P21796,Q9H7Z7,Q9NQX7,Q7Z569,P52292,Q99623,Q9NZ08,Q15388,Q8TEX9,Q03518,P10321,Q99735,Q9NZJ7,O00264,Q9Y680 31 +Flavin adenine dinucleotide binding 0.3280325967859812 0.3902277690028549 0.6963681293979835 1.0 0.9345993315604516 31 P16435,O95831,Q16134,Q15392,Q14534,O00116,P09622,O15254,A1L0T0 9 +Carbon sulfur lyase activity 0.4281893798917455 0.36649270881459 0.7139974522607508 1.0 0.9429510876350038 6 Q99735 1 +Intermediate filament binding 0.6081231394176863 0.3477935119236609 0.7279952625833535 1.0 0.9526649413793716 3 P08670 1 +Snare binding 0.322401201821935 0.346510192150285 0.7289593258822156 1.0 0.9526649413793716 32 Q86Y82,Q9BVK6,O60499,P49755,O15400,Q9P253,Q6ZWJ1,Q9UNK0,P51809,Q99747 10 +Dipeptidyl peptidase activity 0.502633890547981 0.3407992271509162 0.7332547323147236 1.0 0.9526649413793716 4 P42785 1 +Carbon carbon lyase activity 0.3313433615721052 0.3385664810327514 0.7349363370110624 1.0 0.9538240679210488 20 Q9UG56,O95470,P38435 3 +Glucose binding 0.4144327972278709 0.3101387853188003 0.7564554189548871 1.0 0.9670540889492788 6 P52789 1 +Phosphatidylglycerol binding 0.5926353302895089 0.305815568979182 0.7597450737044757 1.0 0.9670540889492788 3 O60313 1 +Beta tubulin binding 0.331575031401943 0.3014328958775803 0.763084412823829 1.0 0.9670540889492788 18 O14737,O75381 2 +Pdz domain binding 0.3319176914363666 0.2879063446167773 0.7734184301564202 1.0 0.9670540889492788 17 O14578,P23634,P78310,P20020,P63218,P51790 6 +Carbonyl reductase nadph activity 0.4815831269646868 0.2760747237093906 0.7824906740695503 1.0 0.9670540889492788 4 Q96LJ7 1 +Polyubiquitin modification dependent protein binding 0.3333159045612198 0.2712188360526938 0.7862227266684645 1.0 0.9682007649487624 15 Q9NRR5,P54725,P46379,Q04323 4 +Sphingolipid transfer activity 0.5790236691630213 0.2709237263298717 0.7864496962606109 1.0 0.9682007649487624 3 Q9NZD2 1 +Protein methyltransferase activity 0.3128180348499844 0.268322992733853 0.7884507092870794 1.0 0.9682007649487624 27 O96028,Q6P2P2,Q14166,Q9BV86,O60725 5 +Growth factor binding 0.345264195981496 0.2669485107338623 0.7895088052794332 1.0 0.9682007649487624 13 O00165,O43847,Q92896,Q15375 4 +Chloride channel regulator activity 0.5770102650154891 0.2659284773946922 0.7902942927154846 1.0 0.9682007649487624 3 O15400 1 +Lysophospholipase activity 0.3863141524105726 0.2028025329651986 0.8392893780584672 1.0 0.9994312681449322 6 Q8IY17,O75608,Q8NCC3,Q8N2K0,Q8N9F7 5 +Hsp70 protein binding 0.3198127925116965 0.2011753956708367 0.8405614295951327 1.0 0.9994312681449322 16 Q9NUL3,P53602,Q9UNE7,P46379,P31689,Q8IXB1,O75937,P25685,Q96EY1,P37198,Q08752,P02786,P06493,P23396,O60884 15 +Lrr domain binding 0.5545200372786512 0.1846808840971932 0.8534793405339434 1.0 1.0 2 Q9Y6N7 1 +Racemase and epimerase activity acting on carbohydrates and derivatives 0.5407013378164022 0.1836229274175332 0.854309275468969 1.0 1.0 3 O94923 1 +Estradiol 17 beta dehydrogenase activity 0.390982227522288 0.1807295578548405 0.8565798570005982 1.0 1.0 5 Q8NBQ5,Q53GQ0 2 +Oxidoreductase activity acting on the ch nh2 group of donors 0.5501708605156767 0.1767157575139283 0.8597316629688183 1.0 1.0 2 P00367 1 +Phosphotransferase activity phosphate group as acceptor 0.3170947571637318 0.1765070568142224 0.8598956051837556 1.0 1.0 15 Q14168,Q9UIJ7 2 +Oxidoreductase activity 0.3955465824012038 0.169507390001651 0.8653975600924602 1.0 1.0 236 Q9P0J0,Q3SXM5,Q6UW02,P20674,Q8IZ83,Q9H9P8,Q8N4Q0,Q15392,Q7KZN9,Q9UDW1,P09622,O43819,Q15800,P03886,P40939,O43169,Q6ZRP7,O43676,Q9NZ01,Q9NRG7,Q16836,O95139,Q9Y394,P09601,P14406,O43175,O14548,P31350,P08574,P30519,P13674,Q96CU9,Q9Y320,P00403,P51648,Q9H7Z7,O00625,Q13423,Q16850,O15460,Q9UHG3,Q9UBM7,P16435,P48163,Q96JJ7,O95831,P13073,O95168,Q14534,Q53GQ0,O95299,O96000,Q9Y6M9,Q96LJ7,Q8TED1,P21912,Q14739,Q99735,Q6YN16,Q8WWV3,Q8NBN7,Q9NVH6,Q9H3N1,Q8NBX0,P04035,O00116,P51970,O15254,Q08257,Q06136 70 +Acyltransferase activity 0.2796028998399019 0.1611098702071887 0.8720068664993659 1.0 1.0 54 Q9HCL2,Q96N66,Q9UJ14,Q9NUQ2,Q96G23,O15269,P40939,P23786,Q92604,Q8NF37 10 +Syntaxin 1 binding 0.4382965495803642 0.1601724486108911 0.8727452319882276 1.0 1.0 4 P46459,O75150,Q15833 3 +Phosphatase activator activity 0.3804789447459162 0.1487919461871183 0.8817178059076027 1.0 1.0 5 Q6IN85,Q15257,P35269 3 +Protein macromolecule adaptor activity 0.279770882013777 0.1413142826622939 0.8876216669082155 1.0 1.0 90 Q86Y82,O15498,Q9UH99,P07196,Q92542,Q9P2W9,P56589,Q9UNK0,Q13616,O95249,Q9BTX1,Q12981,Q99747,P61962,O60499,O15400,Q8TD16,Q8WXH0,Q9UKR5,Q99828,P54709,O94901,O75396 23 +Leucine binding 0.5256290773532043 0.1363884743913433 0.8915141846407983 1.0 1.0 2 P00367 1 +Protein kinase b binding 0.5234544889717153 0.1331903056744151 0.8940428774907347 1.0 1.0 2 Q9UKG1 1 +Acetyl coa hydrolase activity 0.5102548166563219 0.1265812603087 0.8992718297254068 1.0 1.0 3 O14734,P42765 2 +Alcohol dehydrogenase nadpplus activity 0.3445850964409157 0.120916834441972 0.9037569080519056 1.0 1.0 8 Q8NBN7 1 +Dolichyl phosphate mannose protein mannosyltransferase activity 0.5141348244796476 0.120162769003722 0.904354210055696 1.0 1.0 2 Q6ZXV5 1 +Phosphatidylinositol 3 kinase regulator activity 0.5138241689965821 0.1197473143247368 0.9046833185830528 1.0 1.0 2 O00459 1 +Rna strand annealing activity 0.3687810945273579 0.115415794154436 0.9081155606945795 1.0 1.0 5 O00571,Q15056,P23588,P51114 4 +Pyruvate dehydrogenase acetyl transferring kinase activity 0.5015537600994503 0.1123489556247297 0.9105467265033436 1.0 1.0 3 O14874,Q15120 2 +17 beta hydroxysteroid dehydrogenase nadplus activity 0.4148118808750664 0.1082044179204176 0.9138335405409236 1.0 1.0 4 Q8NBQ5,Q53GQ0 2 +Acetylglucosaminyltransferase activity 0.4125202966272533 0.1035703761609909 0.9175102975999154 1.0 1.0 4 P06865 1 +Lyase activity 0.2640475001878511 0.0965484074256027 0.923085029897584 1.0 1.0 59 P48163,Q9UG56,P22830,O95470,P38435,Q9P035,Q9H7Z7,P40939,Q96EM0,Q99735 10 +Pre mrna intronic binding 0.3582089552238714 0.0873357728646831 0.9304046200088336 1.0 1.0 5 Q6P2Q9,Q9BWF3,P22626,Q13148 4 +Dna binding bending 0.3496111975116627 0.0822636244924292 0.9344370797951906 1.0 1.0 6 Q12948,P26583,P09429,O15347,Q00059 5 +Tropomyosin binding 0.4784094439266816 0.07997712700052 0.9362554476951104 1.0 1.0 2 Q9NYL9 1 +Gtp dependent protein binding 0.3221591875553157 0.0714640331050102 0.9430284487660724 1.0 1.0 9 Q9BZG1,O00203 2 +Class i dna apurinic or apyrimidinic site endonuclease activity 0.4659832246039112 0.0693578695950765 0.9447047633155709 1.0 1.0 2 P78549 1 +Phospholipid transfer activity 0.3932235001554365 0.067680867418557 0.9460396799709818 1.0 1.0 4 Q9NZD2,Q9Y5P4,P48739 3 +Insulin like growth factor receptor binding 0.4689247980111987 0.067088364062349 0.946511357158595 1.0 1.0 3 Q04917,P46108 2 +Dynein heavy chain binding 0.4510717614165884 0.0586508993793553 0.9532301685860276 1.0 1.0 2 Q13409 1 +Jun kinase binding 0.4473438956197368 0.0562969663790404 0.9551052354829366 1.0 1.0 2 Q05397 1 +Fibroblast growth factor binding 0.3434567658928462 0.0515965764721641 0.9588501472877552 1.0 1.0 5 Q92896 1 +Glutathione disulfide oxidoreductase activity 0.4324324324324304 0.0480617543491483 0.961667026569335 1.0 1.0 2 P78417 1 +Transmembrane transporter binding 0.283501850146614 0.0464644211375909 0.9629400912621432 1.0 1.0 31 Q96PU5,P30536,P21796,Q99828,P16615 5 +Aldo keto reductase nadp activity 0.3155001853019965 0.0464029278840725 0.9629891029145492 1.0 1.0 9 Q8NBN7 1 +Steroid dehydrogenase activity acting on the ch oh group of donors nad or nadp as acceptor 0.3342962581016862 0.0396448155853376 0.9683762978343732 1.0 1.0 6 Q8NBQ5,Q53GQ0 2 +Ribosome binding 0.2809082002802837 0.0345852330677739 0.972410476760853 1.0 1.0 39 Q15070,O95202 2 +Cytokine activity 0.3355263042864874 0.0340832847022866 0.9728107376162336 1.0 1.0 5 P43490 1 +Long chain fatty acyl coa binding 0.3675054364709452 0.0289716557335837 0.9768871965494286 1.0 1.0 2 P22307 1 +Inositol tetrakisphosphate phosphatase activity 0.3423423423423405 0.0262464767062321 0.9790607455852324 1.0 1.0 2 Q01968 1 +Protein serine threonine kinase inhibitor activity 0.308333122274078 0.020684902562265 0.9834970124545764 1.0 1.0 9 P10644,Q99828 2 +Transforming growth factor beta receptor binding 0.4123679303915621 0.0165234550177011 0.986816790243005 1.0 1.0 3 Q9UNH7,Q96AC1 2 +Ubiquitin ligase substrate adaptor activity 0.4098819142324507 0.0150067705247323 0.9880267788936992 1.0 1.0 3 P63208,O75340 2 +Nad binding 0.2776513718404937 0.0094887991417366 0.9924291472742872 1.0 1.0 29 Q13423,P40939,Q16836,O43175 4 +Hydrolase activity acting on carbon nitrogen but not peptide bonds 0.2752767639844017 0.0071220846495855 0.9943174466577962 1.0 1.0 25 Q13510 1 +Phosphatidylcholine transporter activity 0.3931013051584889 0.0060736675715136 0.9951539442119708 1.0 1.0 3 P08183,P48739 2 +Phosphatidyl phospholipase b activity 0.3859540087010658 0.0029080007815326 0.9976797543437936 1.0 1.0 3 Q8NCC3,Q8IY17 2 +Trna methyltransferase activity 0.309368191721134 0.0011675679472478 0.9990684157728608 1.0 1.0 8 Q7Z2T5,Q08J23,Q13395,O75648,P57081,Q7L0Y3,Q7Z4G4 7 diff --git a/msigdb_gomf/selections.json b/msigdb_gomf/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..d0f6eb5e3b6a9cdbc82322347b0d2c2fe3f659a8 --- /dev/null +++ b/msigdb_gomf/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["1 4 alpha oligoglucan phosphorylase activity", "1 acylglycerophosphocholine o acyltransferase activity", "1 alkyl 2 acetylglycerophosphocholine esterase activity", "1 phosphatidylinositol 3 kinase activity", "1 phosphatidylinositol 3 kinase regulator activity", "1 phosphatidylinositol 4 kinase activity", "1 phosphatidylinositol 4 phosphate 3 kinase activity", "1 phosphatidylinositol 4 phosphate 5 kinase activity", "1 phosphatidylinositol binding", "14 3 3 protein binding", "17 beta hydroxysteroid dehydrogenase nadplus activity", "17 beta hydroxysteroid dehydrogenase nadpplus activity", "2 acylglycerol 3 phosphate o acyltransferase activity", "2 acylglycerol o acyltransferase activity", "2 iron 2 sulfur cluster binding", "2 oxoglutarate dependent dioxygenase activity", "3 5 dna helicase activity", "3 5 exodeoxyribonuclease activity", "3 5 exonuclease activity", "3 beta hydroxy delta5 steroid dehydrogenase activity", "3 hydroxyacyl coa dehydratase activity", "3 hydroxyacyl coa dehydrogenase activity", "4 iron 4 sulfur cluster binding", "5 3 dna helicase activity", "5 3 exodeoxyribonuclease activity", "5 3 exonuclease activity", "5 deoxyribose 5 phosphate lyase activity", "5alpha androstane 3beta 17beta diol dehydrogenase activity", "5s rrna binding", "7s rna binding", "7sk snrna binding", "Abc type glutathione s conjugate transporter activity", "Abc type transporter activity", "Abc type xenobiotic transporter activity", "Acetyl coa c acetyltransferase activity", "Acetyl coa c acyltransferase activity", "Acetyl coa hydrolase activity", "Acetylcholine receptor binding", "Acetylgalactosaminyltransferase activity", "Acetylglucosaminyltransferase activity", "Acetyltransferase activity", "Acid amino acid ligase activity", "Acid phosphatase activity", "Acid thiol ligase activity", "Acidic amino acid transmembrane transporter activity", "Actin binding", "Actin filament binding", "Actin monomer binding", "Actinin binding", "Active ion transmembrane transporter activity", "Active transmembrane transporter activity", "Acyl carnitine transmembrane transporter activity", "Acyl coa binding", "Acyl coa dehydrogenase activity", "Acyl coa oxidase activity", "Acylglycerol lipase activity", "Acylglycerol o acyltransferase activity", "Acyltransferase activity", "Acyltransferase acyl groups converted into alkyl on transfer", "Adenosine deaminase activity", "Adenyl nucleotide binding", "Adenyl nucleotide exchange factor activity", "Adenylate cyclase binding", "Adenylate kinase activity", "Adenylyltransferase activity", "Adp binding", "Adp ribose diphosphatase activity", "Adp transmembrane transporter activity", "Adrenergic receptor binding", "Alanine transmembrane transporter activity", "Alcohol binding", "Alcohol dehydrogenase activity zinc dependent", "Alcohol dehydrogenase nad p plus activity", "Alcohol dehydrogenase nadpplus activity", "Aldehyde dehydrogenase nad p plus activity", "Aldehyde lyase activity", "Alditol nadpplus 1 oxidoreductase activity", "Aldo keto reductase nadp activity", "Alkali metal ion binding", "Alpha actinin binding", "Alpha catenin binding", "Alpha glucosidase activity", "Alpha tubulin binding", "Amide binding", "Amide transmembrane transporter activity", "Amidine lyase activity", "Amino acid binding", "Amino acid transmembrane transporter activity", "Aminoacyl trna editing activity", "Aminoacylase activity", "Aminoacyltransferase activity", "Aminopeptidase activity", "Ammonium transmembrane transporter activity", "Amp activated protein kinase activity", "Amp binding", "Amyloid beta binding", "Anaphase promoting complex binding", "Androgen receptor binding", "Androstan 3 alpha 17 beta diol dehydrogenase activity", "Anion cation symporter activity", "Anion channel activity", "Anion sodium symporter activity", "Anion transmembrane transporter activity", "Ankyrin binding", "Ankyrin repeat binding", "Annealing activity", "Antigen binding", "Antioxidant activity", "Antiporter activity", "Apolipoprotein a i binding", "Apolipoprotein binding", "Apolipoprotein receptor binding", "Arachidonate coa ligase activity", "Arginine binding", "Armadillo repeat domain binding", "Aromatic amino acid transmembrane transporter activity", "Arp2 3 complex binding", "Arrestin family protein binding", "Aryl hydrocarbon receptor binding", "Arylesterase activity", "Arylsulfatase activity", "Aspartic endopeptidase activity intramembrane cleaving", "Aspartic type endopeptidase inhibitor activity", "Aspartic type peptidase activity", "Atp dependent activity", "Atp dependent activity acting on dna", "Atp dependent activity acting on rna", "Atp dependent chromatin remodeler activity", "Atp dependent dna dna annealing activity", "Atp dependent peptidase activity", "Atp dependent protein binding", "Atp hydrolysis activity", "Atp transmembrane transporter activity", "Atpase activator activity", "Atpase binding", "Atpase coupled cation transmembrane transporter activity", "Atpase coupled inorganic anion transmembrane transporter activity", "Atpase coupled intramembrane lipid transporter activity", "Atpase coupled ion transmembrane transporter activity", "Atpase coupled lipid transmembrane transporter activity", "Atpase coupled transmembrane transporter activity", "Atpase inhibitor activity", "Atpase regulator activity", "Axon guidance receptor activity", "Azole transmembrane transporter activity", "Basal transcription machinery binding", "Basic amino acid transmembrane transporter activity", "Benzodiazepine receptor activity", "Beta 1 3 galactosyltransferase activity", "Beta 2 adrenergic receptor binding", "Beta 2 microglobulin binding", "Beta catenin binding", "Beta galactosidase activity", "Beta n acetylhexosaminidase activity", "Beta tubulin binding", "Bh domain binding", "Bh3 domain binding", "Bhlh transcription factor binding", "Bile acid binding", "Bile acid transmembrane transporter activity", "Biotin binding", "Bmp receptor binding", "Box h aca snorna binding", "Branched chain amino acid transmembrane transporter activity", "Bubble dna binding", "C acetyltransferase activity", "C acyltransferase activity", "C methyltransferase activity", "C palmitoyltransferase activity", "C x c chemokine binding", "C x3 c chemokine binding", "C2h2 zinc finger domain binding", "C3hc4 type ring finger domain binding", "C4 dicarboxylate transmembrane transporter activity", "Cadherin binding", "Cadherin binding involved in cell cell adhesion", "Calcium activated cation channel activity", "Calcium cation antiporter activity", "Calcium channel inhibitor activity", "Calcium channel regulator activity", "Calcium dependent cysteine type endopeptidase activity", "Calcium dependent phospholipid binding", "Calcium dependent protein binding", "Calcium dependent protein kinase activity", "Calcium dependent protein serine threonine phosphatase activity", "Calcium independent phospholipase a2 activity", "Calcium ion binding", "Calcium ion transmembrane transporter activity", "Calmodulin binding", "Calmodulin dependent protein kinase activity", "Calmodulin dependent protein phosphatase activity", "Camp binding", "Camp dependent protein kinase activity", "Camp dependent protein kinase inhibitor activity", "Camp dependent protein kinase regulator activity", "Carbohydrate binding", "Carbohydrate derivative transmembrane transporter activity", "Carbohydrate kinase activity", "Carbohydrate phosphatase activity", "Carbon carbon lyase activity", "Carbon nitrogen ligase activity with glutamine as amido n donor", "Carbon nitrogen lyase activity", "Carbon oxygen lyase activity", "Carbon sulfur lyase activity", "Carbonyl reductase nadph activity", "Carboxy lyase activity", "Carboxylic acid binding", "Carboxylic ester hydrolase activity", "Carboxypeptidase activity", "Card domain binding", "Cardiolipin binding", "Cargo adaptor activity", "Cargo receptor activity", "Carnitine o acyltransferase activity", "Catalytic activity acting on a glycoprotein", "Catalytic activity acting on a nucleic acid", "Catalytic activity acting on a rrna", "Catalytic activity acting on a trna", "Catalytic activity acting on dna", "Catalytic activity acting on rna", "Cation cation antiporter activity", "Cation channel activity", "Cation chloride symporter activity", "Cation transmembrane transporter activity", "Ccr chemokine receptor binding", "Ccr3 chemokine receptor binding", "Ccr5 chemokine receptor binding", "Cdp alcohol phosphatidyltransferase activity", "Cell adhesion mediator activity", "Cell adhesion molecule binding", "Cell adhesive protein binding involved in bundle of his cell purkinje myocyte communication", "Cell cell adhesion mediator activity", "Cell matrix adhesion mediator activity", "Centromeric dna binding", "Ceramide 1 phosphate binding", "Ceramide 1 phosphate transfer activity", "Ceramide binding", "Cgmp binding", "Channel inhibitor activity", "Channel regulator activity", "Chaperone binding", "Chemoattractant activity", "Chemokine binding", "Chemokine receptor binding", "Chemorepellent activity", "Chitin binding", "Chloride channel inhibitor activity", "Chloride channel regulator activity", "Chloride ion binding", "Chloride transmembrane transporter activity", "Cholesterol binding", "Chondroitin sulfate binding", "Chromatin binding", "Chromatin dna binding", "Chromo shadow domain binding", "Cis regulatory region sequence specific dna binding", "Cis trans isomerase activity", "Class i dna apurinic or apyrimidinic site endonuclease activity", "Clathrin binding", "Clathrin heavy chain binding", "Clathrin light chain binding", "Co smad binding", "Coa hydrolase activity", "Coa transferase activity", "Cobalamin binding", "Collagen binding", "Collagen binding involved in cell matrix adhesion", "Complement binding", "Complement component c1q complex binding", "Complement component c3b binding", "Connexin binding", "Copper chaperone activity", "Copper ion binding", "Copper ion transmembrane transporter activity", "Core promoter sequence specific dna binding", "Coreceptor activity", "Coreceptor activity involved in wnt signaling pathway", "Coreceptor activity involved in wnt signaling pathway planar cell polarity pathway", "Crossover junction endodeoxyribonuclease activity", "Cullin family protein binding", "Cuprous ion binding", "Cxcr chemokine receptor binding", "Cyclase activity", "Cyclic nucleotide binding", "Cyclic nucleotide dependent protein kinase activity", "Cyclic nucleotide phosphodiesterase activity", "Cyclin binding", "Cyclin dependent protein kinase activity", "Cyclin dependent protein serine threonine kinase activator activity", "Cyclin dependent protein serine threonine kinase inhibitor activity", "Cyclin dependent protein serine threonine kinase regulator activity", "Cyclohydrolase activity", "Cyclosporin a binding", "Cysteine type endopeptidase activity", "Cysteine type endopeptidase inhibitor activity", "Cysteine type endopeptidase inhibitor activity involved in apoptotic process", "Cysteine type endopeptidase regulator activity involved in apoptotic process", "Cysteine type exopeptidase activity", "Cysteine type peptidase activity", "Cytidylyltransferase activity", "Cytochrome b5 reductase activity acting on nad p h", "Cytokine activity", "Cytokine binding", "Cytokine receptor binding", "Cytoskeletal anchor activity", "Cytoskeletal motor activity", "Cytoskeletal protein binding", "Cytoskeleton nuclear membrane anchor activity", "D loop dna binding", "D threo aldose 1 dehydrogenase activity", "D1 dopamine receptor binding", "Damaged dna binding", "Deacetylase activity", "Dead h box rna helicase binding", "Deaminase activity", "Death domain binding", "Death receptor activity", "Death receptor binding", "Demethylase activity", "Deoxynucleoside kinase activity", "Deoxyribonuclease activity", "Deoxyribonuclease i activity", "Diacylglycerol binding", "Diacylglycerol kinase activity", "Dicarboxylic acid transmembrane transporter activity", "Dihydropyrimidinase activity", "Dioxygenase activity", "Dipeptidase activity", "Dipeptidyl peptidase activity", "Diphosphotransferase activity", "Disordered domain specific binding", "Disulfide oxidoreductase activity", "Dna apurinic or apyrimidinic site endonuclease activity", "Dna binding bending", "Dna binding transcription activator activity", "Dna binding transcription factor activity", "Dna binding transcription factor binding", "Dna binding transcription repressor activity", "Dna clamp loader activity", "Dna directed dna polymerase activity", "Dna dna annealing activity", "Dna helicase activity", "Dna insertion or deletion binding", "Dna methyltransferase activity", "Dna n glycosylase activity", "Dna polymerase activity", "Dna polymerase binding", "Dna replication origin binding", "Dna secondary structure binding", "Dna topoisomerase activity", "Dna translocase activity", "Dolichyl diphosphooligosaccharide protein glycotransferase activity", "Dolichyl phosphate mannose protein mannosyltransferase activity", "Dopamine receptor binding", "Double stranded methylated dna binding", "Double stranded rna adenosine deaminase activity", "Double stranded rna binding", "Double stranded telomeric dna binding", "Dttp diphosphatase activity", "Dynactin binding", "Dynein complex binding", "Dynein heavy chain binding", "Dynein intermediate chain binding", "Dynein light chain binding", "Dynein light intermediate chain binding", "Dystroglycan binding", "E box binding", "Efflux transmembrane transporter activity", "Electron transfer activity", "Endodeoxyribonuclease activity", "Endodeoxyribonuclease activity producing 3 phosphomonoesters", "Endodeoxyribonuclease activity producing 5 phosphomonoesters", "Endonuclease activity", "Endonuclease activity active with either ribo or deoxyribonucleic acids and producing 3 phosphomonoesters", "Endonuclease activity active with either ribo or deoxyribonucleic acids and producing 5 phosphomonoesters", "Endopeptidase activator activity", "Endopeptidase activity", "Endopeptidase regulator activity", "Endoribonuclease activity", "Endoribonuclease activity producing 3 phosphomonoesters", "Endoribonuclease activity producing 5 phosphomonoesters", "Enoyl coa hydratase activity", "Enzyme activator activity", "Enzyme inhibitor activity", "Enzyme regulator activity", "Ephrin receptor activity", "Ephrin receptor binding", "Epidermal growth factor receptor binding", "Epoxide hydrolase activity", "Er retention sequence binding", "Erbb 3 class receptor binding", "Estradiol 17 beta dehydrogenase activity", "Estrogen receptor binding", "Ether hydrolase activity", "Eukaryotic initiation factor 4e binding", "Exodeoxyribonuclease activity", "Exogenous protein binding", "Exonuclease activity", "Exonuclease activity active with either ribo or deoxyribonucleic acids and producing 5 phosphomonoesters", "Exopeptidase activity", "Exoribonuclease activity", "Exoribonuclease activity producing 5 phosphomonoesters", "Extracellular matrix binding", "Extracellular matrix constituent conferring elasticity", "Extracellular matrix structural constituent", "Fad binding", "Fatty acid binding", "Fatty acid derivative binding", "Fatty acid ligase activity", "Fatty acid synthase activity", "Fatty acid transmembrane transporter activity", "Ferric iron binding", "Ferrous iron binding", "Fibroblast growth factor binding", "Fibronectin binding", "Filamin binding", "Fk506 binding", "Flap endonuclease activity", "Flavin adenine dinucleotide binding", "Flippase activity", "Floppase activity", "Fmn binding", "Folic acid binding", "Folic acid transmembrane transporter activity", "Four way junction dna binding", "Four way junction helicase activity", "Frizzled binding", "Fructose 2 6 bisphosphate 2 phosphatase activity", "Fructose 6 phosphate binding", "Fructose binding", "Fucosyltransferase activity", "G protein activity", "G protein alpha subunit binding", "G protein beta gamma subunit complex binding", "G protein beta subunit binding", "G protein coupled glutamate receptor binding", "G protein coupled opioid receptor activity", "G protein coupled receptor activity", "G protein coupled receptor binding", "G protein coupled serotonin receptor binding", "G quadruplex dna binding", "G quadruplex rna binding", "G rich strand telomeric dna binding", "Gaba receptor binding", "Galactosidase activity", "Galactoside binding", "Galactosyltransferase activity", "Gamma aminobutyric acid transmembrane transporter activity", "Gamma catenin binding", "Gamma tubulin binding", "Ganglioside binding", "Gated channel activity", "Gdp binding", "Gdp dissociation inhibitor activity", "General transcription initiation factor activity", "General transcription initiation factor binding", "Glucocorticoid receptor binding", "Glucose binding", "Glucosidase activity", "Glucosyltransferase activity", "Glucuronosyl n acetylgalactosaminyl proteoglycan 4 beta n acetylgalactosaminyltransferase activity", "Glucuronosyltransferase activity", "Glutamate binding", "Glutamate receptor binding", "Glutathione disulfide oxidoreductase activity", "Glutathione hydrolase activity", "Glutathione oxidoreductase activity", "Glutathione peroxidase activity", "Glutathione transferase activity", "Glutathione transmembrane transporter activity", "Glyceraldehyde 3 phosphate dehydrogenase nadplus non phosphorylating activity", "Glycerophospholipid flippase activity", "Glycine binding", "Glycolipid binding", "Glycolipid mannosyltransferase activity", "Glycosaminoglycan binding", "Glycosphingolipid binding", "Glycosyltransferase activity", "Gpi anchor binding", "Gpi linked ephrin receptor activity", "Growth factor activity", "Growth factor binding", "Growth factor receptor binding", "Gtp dependent protein binding", "Gtpase activating protein binding", "Gtpase activator activity", "Gtpase activity", "Gtpase binding", "Gtpase inhibitor activity", "Guanosine diphosphatase activity", "Guanyl nucleotide binding", "Guanyl nucleotide exchange factor activity", "Guanylate kinase activity", "H4 histone acetyltransferase activity", "Heat shock protein binding", "Helicase activity", "Heme transmembrane transporter activity", "Heparan sulfate proteoglycan binding", "Heparan sulfate sulfotransferase activity", "Heparin binding", "Hexokinase activity", "Hexosaminidase activity", "Hexosyltransferase activity", "High density lipoprotein particle binding", "Histone acetyltransferase binding", "Histone arginine n methyltransferase activity", "Histone binding", "Histone deacetylase activity h3 k14 specific", "Histone deacetylase binding", "Histone deacetylase regulator activity", "Histone h3 di monomethyl lysine 9 demethylase activity", "Histone h3 methyl lysine 36 demethylase activity", "Histone h3 methyl lysine 4 demethylase activity", "Histone h3 methyl lysine 9 demethylase activity", "Histone h3 tri di monomethyl lysine 4 demethylase activity", "Histone kinase activity", "Histone lysine n methyltransferase activity", "Histone methyltransferase activity", "Histone methyltransferase activity h3 k36 specific", "Histone methyltransferase activity h3 k4 specific", "Histone methyltransferase activity h3 k9 specific", "Histone methyltransferase activity h4 k20 specific", "Histone methyltransferase binding", "Histone serine kinase activity", "Histone threonine kinase activity", "Hormone activity", "Hormone binding", "Hormone receptor binding", "Hsp70 protein binding", "Hsp90 protein binding", "Hyaluronic acid binding", "Hyalurononglucosaminidase activity", "Hydro lyase activity", "Hydrolase activity acting on acid anhydrides", "Hydrolase activity acting on carbon nitrogen but not peptide bonds", "Hydrolase activity acting on carbon nitrogen but not peptide bonds in cyclic amides", "Hydrolase activity acting on carbon nitrogen but not peptide bonds in cyclic amidines", "Hydrolase activity acting on carbon nitrogen but not peptide bonds in linear amides", "Hydrolase activity acting on carbon nitrogen but not peptide bonds in linear amidines", "Hydrolase activity acting on ester bonds", "Hydrolase activity acting on ether bonds", "Hydrolase activity acting on glycosyl bonds", "Hydrolase activity hydrolyzing n glycosyl compounds", "Hydrolase activity hydrolyzing o glycosyl compounds", "Hydroxymethyl formyl and related transferase activity", "Hypoglycin a gamma glutamyl transpeptidase activity", "I smad binding", "Identical protein binding", "Ige binding", "Immunoglobulin binding", "Immunoglobulin receptor binding", "Importin alpha family protein binding", "Inorganic anion exchanger activity", "Inorganic anion transmembrane transporter activity", "Inorganic diphosphatase activity", "Inorganic molecular entity transmembrane transporter activity", "Inorganic phosphate transmembrane transporter activity", "Inositol 1 4 5 trisphosphate 5 phosphatase activity", "Inositol bisphosphate phosphatase activity", "Inositol phosphate phosphatase activity", "Inositol polyphosphate 5 phosphatase activity", "Inositol tetrakisphosphate phosphatase activity", "Inositol trisphosphate kinase activity", "Inositol trisphosphate phosphatase activity", "Insulin binding", "Insulin like growth factor binding", "Insulin like growth factor ii binding", "Insulin like growth factor receptor binding", "Insulin receptor binding", "Insulin receptor substrate binding", "Integrin binding", "Interleukin 1 binding", "Interleukin 1 receptor binding", "Interleukin 2 receptor binding", "Interleukin 6 receptor binding", "Intermediate filament binding", "Intracellular calcium activated chloride channel activity", "Intraciliary transport particle b binding", "Intramembrane lipid transporter activity", "Intramolecular oxidoreductase activity", "Intramolecular oxidoreductase activity interconverting aldoses and ketoses", "Intramolecular oxidoreductase activity transposing c c bonds", "Intramolecular transferase activity", "Intramolecular transferase activity phosphotransferases", "Ion gated channel activity", "Ion transmembrane transporter activity", "Ionotropic glutamate receptor binding", "Iron ion binding", "Iron ion transmembrane transporter activity", "Isocitrate dehydrogenase activity", "Isomerase activity", "Isopeptidase activity", "Isoprenoid binding", "Jun kinase binding", "Jun kinase kinase kinase activity", "K48 linked polyubiquitin modification dependent protein binding", "K63 linked polyubiquitin modification dependent protein binding", "Keratin filament binding", "Kinase activator activity", "Kinase activity", "Kinase binding", "Kinase inhibitor activity", "Kinase regulator activity", "Kinesin binding", "Kinetochore binding", "L alanine transmembrane transporter activity", "L amino acid transmembrane transporter activity", "L arginine transmembrane transporter activity", "L ascorbic acid binding", "L aspartate transmembrane transporter activity", "L glutamine transmembrane transporter activity", "L histidine transmembrane transporter activity", "L lactate dehydrogenase activity", "L leucine transmembrane transporter activity", "L lysine transmembrane transporter activity", "L ornithine transmembrane transporter activity", "L serine transmembrane transporter activity", "Lactate dehydrogenase activity", "Lactate transmembrane transporter activity", "Lamin binding", "Laminin 1 binding", "Laminin binding", "Large ribosomal subunit rrna binding", "Leucine binding", "Leucine zipper domain binding", "Leukotriene c4 synthase activity", "Ligand gated ion channel activity", "Ligase activity", "Ligase activity forming carbon carbon bonds", "Ligase activity forming carbon nitrogen bonds", "Ligase activity forming carbon oxygen bonds", "Ligase activity forming carbon sulfur bonds", "Ligase activity forming phosphoric ester bonds", "Lim domain binding", "Lipase activator activity", "Lipase activity", "Lipase binding", "Lipase inhibitor activity", "Lipid binding", "Lipid kinase activity", "Lipid phosphatase activity", "Lipid transfer activity", "Lipid transporter activity", "Lipopolysaccharide binding", "Lipopolysaccharide immune receptor activity", "Lipoprotein particle receptor activity", "Lipoprotein particle receptor binding", "Long chain acyl coa dehydrogenase activity", "Long chain fatty acid binding", "Long chain fatty acid coa ligase activity", "Long chain fatty acid transporter activity", "Long chain fatty acyl coa binding", "Low density lipoprotein particle binding", "Low density lipoprotein particle receptor activity", "Low density lipoprotein particle receptor binding", "Lrr domain binding", "Lyase activity", "Lys48 specific deubiquitinase activity", "Lys63 specific deubiquitinase activity", "Lysine acetylated histone binding", "Lysine n methyltransferase activity", "Lysophosphatidic acid binding", "Lysophosphatidic acid phosphatase activity", "Lysophospholipase activity", "Lysophospholipid acyltransferase activity", "M7g 5 pppn diphosphatase activity", "Macrolide binding", "Macromolecule transmembrane transporter activity", "Magnesium ion binding", "Magnesium ion transmembrane transporter activity", "Malate dehydrogenase activity", "Manganese ion binding", "Manganese ion transmembrane transporter activity", "Mannose binding", "Mannosidase activity", "Mannosyl oligosaccharide mannosidase activity", "Mannosyltransferase activity", "Map kinase activity", "Map kinase kinase activity", "Map kinase kinase kinase activity", "Map kinase phosphatase activity", "Map kinase scaffold activity", "Map kinase tyrosine serine threonine phosphatase activity", "Mdm2 mdm4 family protein binding", "Medium chain fatty acid coa ligase activity", "Membrane insertase activity", "Metal cluster binding", "Metal dependent deubiquitinase activity", "Metal ion proton antiporter activity", "Metal ion transmembrane transporter activity", "Metalloaminopeptidase activity", "Metallocarboxypeptidase activity", "Metallochaperone activity", "Metallodipeptidase activity", "Metalloendopeptidase activity", "Metalloexopeptidase activity", "Metallopeptidase activity", "Methyl cpg binding", "Methylated histone binding", "Mhc class i protein binding", "Mhc class ib protein binding", "Mhc class ii protein complex binding", "Mhc protein binding", "Mhc protein complex binding", "Microfilament motor activity", "Microtubule binding", "Microtubule minus end binding", "Microtubule motor activity", "Microtubule plus end binding", "Minor groove of adenine thymine rich dna binding", "Minus end directed microtubule motor activity", "Mirna binding", "Misfolded protein binding", "Mismatch repair complex binding", "Mismatched dna binding", "Mitochondrial ribosome binding", "Mitochondrion targeting sequence binding", "Mitogen activated protein kinase binding", "Mitogen activated protein kinase kinase binding", "Mitogen activated protein kinase kinase kinase binding", "Mitogen activated protein kinase p38 binding", "Modification dependent protein binding", "Modified amino acid binding", "Modified amino acid transmembrane transporter activity", "Molecular adaptor activity", "Molecular carrier activity", "Molecular function activator activity", "Molecular function inhibitor activity", "Molecular function regulator", "Molecular transducer activity", "Molybdopterin cofactor binding", "Monocarboxylic acid binding", "Monocarboxylic acid transmembrane transporter activity", "Monooxygenase activity", "Monosaccharide binding", "Mrf binding", "Mrna 3 utr au rich region binding", "Mrna 3 utr binding", "Mrna 5 utr binding", "Mrna binding", "Mrna methyltransferase activity", "Muscle alpha actinin binding", "Mutlalpha complex binding", "Myosin binding", "Myosin ii binding", "Myosin light chain binding", "Myosin v binding", "Myristoyltransferase activity", "N acetylgalactosamine 4 o sulfotransferase activity", "N acetyllactosaminide beta 1 3 n acetylglucosaminyltransferase activity", "N acetyltransferase activity", "N acylsphingosine amidohydrolase activity", "N acyltransferase activity", "N methyltransferase activity", "N6 methyladenosine containing rna binding", "Nad binding", "Nad dependent protein deacetylase activity", "Nad p h oxidase h2o2 forming activity", "Nad p plus nucleosidase activity", "Nad p plus protein arginine adp ribosyltransferase activity", "Nad retinol dehydrogenase activity", "Nadh dehydrogenase activity", "Nadh pyrophosphatase activity", "Nadp binding", "Nadp retinol dehydrogenase activity", "Nadph binding", "Nadplus adp ribosyltransferase activity", "Nadplus binding", "Nadplus kinase activity", "Nadplus nucleosidase activity", "Nedd8 specific protease activity", "Nedd8 transferase activity", "Nerve growth factor binding", "Neurexin family protein binding", "Neuroligin family protein binding", "Neurotransmitter binding", "Neurotransmitter receptor activity", "Neurotransmitter receptor regulator activity", "Neurotrophin binding", "Neurotrophin receptor activity", "Neurotrophin receptor binding", "Neurotrophin trk receptor binding", "Neutral amino acid transmembrane transporter activity", "Nf kappab binding", "Nfat protein binding", "Nitric oxide synthase binding", "Nitric oxide synthase regulator activity", "Nitrite reductase activity", "Non membrane spanning protein tyrosine kinase activity", "Non membrane spanning protein tyrosine phosphatase activity", "Notch binding", "Nuclear export signal receptor activity", "Nuclear import signal receptor activity", "Nuclear localization sequence binding", "Nuclear receptor activity", "Nuclear receptor binding", "Nuclear receptor coactivator activity", "Nuclease activity", "Nucleobase containing compound kinase activity", "Nucleobase containing compound transmembrane transporter activity", "Nucleobase transmembrane transporter activity", "Nucleocytoplasmic carrier activity", "Nucleoside binding", "Nucleoside diphosphatase activity", "Nucleoside diphosphate kinase activity", "Nucleoside kinase activity", "Nucleoside monophosphate kinase activity", "Nucleoside triphosphatase regulator activity", "Nucleoside triphosphate diphosphatase activity", "Nucleosomal dna binding", "Nucleosome binding", "Nucleotidase activity", "Nucleotide diphosphatase activity", "Nucleotide phosphatase activity acting on free nucleotides", "Nucleotide sugar transmembrane transporter activity", "Nucleotide transmembrane transporter activity", "Nucleotidyltransferase activity", "O acetyltransferase activity", "O acyltransferase activity", "O methyltransferase activity", "O palmitoyltransferase activity", "Oleate transmembrane transporter activity", "Oligopeptide binding", "Oligopeptide transmembrane transporter activity", "Oligosaccharide binding", "Oligosaccharyl transferase activity", "Omega peptidase activity", "Opsonin binding", "Organic acid binding", "Organic acid transmembrane transporter activity", "Organic anion transmembrane transporter activity", "Organic cation transmembrane transporter activity", "Organic hydroxy compound transmembrane transporter activity", "Organophosphate ester transmembrane transporter activity", "Oxidative phosphorylation uncoupler activity", "Oxidative rna demethylase activity", "Oxidized dna binding", "Oxidoreductase activity", "Oxidoreductase activity acting on a heme group of donors", "Oxidoreductase activity acting on a sulfur group of donors", "Oxidoreductase activity acting on a sulfur group of donors disulfide as acceptor", "Oxidoreductase activity acting on a sulfur group of donors nad p as acceptor", "Oxidoreductase activity acting on a sulfur group of donors oxygen as acceptor", "Oxidoreductase activity acting on ch oh group of donors", "Oxidoreductase activity acting on ch or ch2 groups", "Oxidoreductase activity acting on diphenols and related substances as donors", "Oxidoreductase activity acting on nad p h", "Oxidoreductase activity acting on nad p h heme protein as acceptor", "Oxidoreductase activity acting on nad p h oxygen as acceptor", "Oxidoreductase activity acting on nad p h quinone or similar compound as acceptor", "Oxidoreductase activity acting on other nitrogenous compounds as donors", "Oxidoreductase activity acting on other nitrogenous compounds as donors cytochrome as acceptor", "Oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen", "Oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen nad p h as one donor and incorporation of one atom of oxygen", "Oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen reduced ascorbate as one donor and incorporation of one atom of oxygen", "Oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen reduced flavin or flavoprotein as one donor and incorporation of one atom of oxygen", "Oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen reduced pteridine as one donor and incorporation of one atom of oxygen", "Oxidoreductase activity acting on paired donors with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water", "Oxidoreductase activity acting on peroxide as acceptor", "Oxidoreductase activity acting on single donors with incorporation of molecular oxygen", "Oxidoreductase activity acting on the aldehyde or oxo group of donors", "Oxidoreductase activity acting on the aldehyde or oxo group of donors disulfide as acceptor", "Oxidoreductase activity acting on the aldehyde or oxo group of donors nad or nadp as acceptor", "Oxidoreductase activity acting on the ch ch group of donors", "Oxidoreductase activity acting on the ch ch group of donors nad or nadp as acceptor", "Oxidoreductase activity acting on the ch ch group of donors oxygen as acceptor", "Oxidoreductase activity acting on the ch nh group of donors", "Oxidoreductase activity acting on the ch nh group of donors nad or nadp as acceptor", "Oxidoreductase activity acting on the ch nh2 group of donors", "Oxidoreduction driven active transmembrane transporter activity", "Oxo acid lyase activity", "Oxygen binding", "Oxygen sensor activity", "Oxysterol binding", "P type calcium transporter activity", "P type potassium transmembrane transporter activity", "P type transmembrane transporter activity", "P53 binding", "Palmitoyl coa hydrolase activity", "Palmitoyl protein hydrolase activity", "Palmitoyltransferase activity", "Passive transmembrane transporter activity", "Patched binding", "Pattern recognition receptor activity", "Pdz domain binding", "Pentosyltransferase activity", "Peptidase activator activity", "Peptidase activator activity involved in apoptotic process", "Peptidase activity", "Peptidase regulator activity", "Peptide alpha n acetyltransferase activity", "Peptide antigen binding", "Peptide binding", "Peptide hormone binding", "Peptide hormone receptor binding", "Peptide lysine n acetyltransferase activity", "Peptide n acetyltransferase activity", "Peptide receptor activity", "Peptide transmembrane transporter activity", "Peptidoglycan binding", "Peptidyl proline 4 dioxygenase activity", "Peptidyl proline dioxygenase activity", "Peroxiredoxin activity", "Peroxisome proliferator activated receptor binding", "Peroxisome targeting sequence binding", "Phosphatase activator activity", "Phosphatase activity", "Phosphatase binding", "Phosphatase inhibitor activity", "Phosphatase regulator activity", "Phosphate ion binding", "Phosphatidic acid binding", "Phosphatidyl phospholipase b activity", "Phosphatidylcholine binding", "Phosphatidylcholine floppase activity", "Phosphatidylcholine transfer activity", "Phosphatidylcholine transporter activity", "Phosphatidylethanolamine binding", "Phosphatidylethanolamine flippase activity", "Phosphatidylglycerol binding", "Phosphatidylinositol 3 4 5 trisphosphate 3 phosphatase activity", "Phosphatidylinositol 3 4 5 trisphosphate 5 phosphatase activity", "Phosphatidylinositol 3 4 5 trisphosphate binding", "Phosphatidylinositol 3 5 bisphosphate 3 phosphatase activity", "Phosphatidylinositol 3 5 bisphosphate 5 phosphatase activity", "Phosphatidylinositol 3 5 bisphosphate binding", "Phosphatidylinositol 3 5 bisphosphate phosphatase activity", "Phosphatidylinositol 3 kinase activity", "Phosphatidylinositol 3 kinase binding", "Phosphatidylinositol 3 kinase regulator activity", "Phosphatidylinositol 3 kinase regulatory subunit binding", "Phosphatidylinositol 3 phosphate binding", "Phosphatidylinositol 4 5 bisphosphate 3 kinase activity", "Phosphatidylinositol 4 5 bisphosphate 5 phosphatase activity", "Phosphatidylinositol 4 5 bisphosphate binding", "Phosphatidylinositol 4 5 bisphosphate phosphatase activity", "Phosphatidylinositol 4 phosphate binding", "Phosphatidylinositol 5 phosphate binding", "Phosphatidylinositol binding", "Phosphatidylinositol bisphosphate binding", "Phosphatidylinositol bisphosphate kinase activity", "Phosphatidylinositol bisphosphate phosphatase activity", "Phosphatidylinositol kinase activity", "Phosphatidylinositol monophosphate phosphatase activity", "Phosphatidylinositol phosphate 4 phosphatase activity", "Phosphatidylinositol phosphate 5 phosphatase activity", "Phosphatidylinositol phosphate binding", "Phosphatidylinositol phosphate kinase activity", "Phosphatidylinositol phosphate phosphatase activity", "Phosphatidylinositol transfer activity", "Phosphatidylinositol trisphosphate phosphatase activity", "Phosphatidylserine 1 acylhydrolase activity", "Phosphatidylserine binding", "Phosphodiesterase i activity", "Phosphofructokinase activity", "Phospholipase a1 activity", "Phospholipase a2 activity", "Phospholipase a2 inhibitor activity", "Phospholipase activity", "Phospholipase binding", "Phospholipase c activity", "Phospholipase d activity", "Phospholipase inhibitor activity", "Phospholipid binding", "Phospholipid scramblase activity", "Phospholipid transfer activity", "Phospholipid transporter activity", "Phosphoprotein binding", "Phosphoprotein phosphatase activity", "Phosphoric diester hydrolase activity", "Phosphoric ester hydrolase activity", "Phosphorus oxygen lyase activity", "Phosphorylation dependent protein binding", "Phosphoserine residue binding", "Phosphotransferase activity for other substituted phosphate groups", "Phosphotransferase activity nitrogenous group as acceptor", "Phosphotransferase activity phosphate group as acceptor", "Phosphotyrosine residue binding", "Platelet derived growth factor receptor binding", "Plus end directed microtubule motor activity", "Poly a binding", "Poly a specific ribonuclease activity", "Poly g binding", "Poly purine tract binding", "Poly pyrimidine tract binding", "Polynucleotide adenylyltransferase activity", "Polypeptide n acetylgalactosaminyltransferase activity", "Polysaccharide binding", "Polysome binding", "Polyubiquitin modification dependent protein binding", "Porin activity", "Potassium channel inhibitor activity", "Potassium channel regulator activity", "Potassium chloride symporter activity", "Potassium ion binding", "Potassium ion transmembrane transporter activity", "Pre mirna binding", "Pre mrna 3 splice site binding", "Pre mrna 5 splice site binding", "Pre mrna binding", "Pre mrna intronic binding", "Prenyltransferase activity", "Primary active transmembrane transporter activity", "Primary mirna binding", "Procollagen proline 4 dioxygenase activity", "Procollagen proline dioxygenase activity", "Profilin binding", "Proline rich region binding", "Promoter specific chromatin binding", "Protease binding", "Proteasome activating activity", "Proteasome binding", "Protein adp ribosylase activity", "Protein antigen binding", "Protein arginine n methyltransferase activity", "Protein arginine omega n asymmetric methyltransferase activity", "Protein arginine omega n monomethyltransferase activity", "Protein binding involved in heterotypic cell cell adhesion", "Protein c terminus binding", "Protein carboxyl o methyltransferase activity", "Protein carrier chaperone", "Protein containing complex binding", "Protein deacetylase activity", "Protein demethylase activity", "Protein dimerization activity", "Protein disaggregase activity", "Protein disulfide isomerase activity", "Protein disulfide reductase nad p activity", "Protein domain specific binding", "Protein folding chaperone", "Protein geranylgeranyltransferase activity", "Protein heterodimerization activity", "Protein homodimerization activity", "Protein kinase a binding", "Protein kinase a catalytic subunit binding", "Protein kinase a regulatory subunit binding", "Protein kinase activity", "Protein kinase b binding", "Protein kinase c activity", "Protein kinase c binding", "Protein lipid complex binding", "Protein macromolecule adaptor activity", "Protein membrane adaptor activity", "Protein methyltransferase activity", "Protein n terminus binding", "Protein phosphatase 1 binding", "Protein phosphatase 2a binding", "Protein phosphatase 2b binding", "Protein phosphatase activator activity", "Protein phosphatase binding", "Protein phosphatase regulator activity", "Protein phosphorylated amino acid binding", "Protein prenyltransferase activity", "Protein self association", "Protein serine kinase activity", "Protein serine threonine kinase activator activity", "Protein serine threonine kinase activity", "Protein serine threonine kinase inhibitor activity", "Protein serine threonine phosphatase activity", "Protein serine threonine phosphatase inhibitor activity", "Protein serine threonine tyrosine kinase activity", "Protein transmembrane transporter activity", "Protein transporter activity", "Protein tyrosine kinase activator activity", "Protein tyrosine kinase activity", "Protein tyrosine kinase binding", "Protein tyrosine kinase inhibitor activity", "Protein tyrosine phosphatase activity", "Protein tyrosine serine threonine phosphatase activity", "Protein tyrosine threonine phosphatase activity", "Proteoglycan binding", "Proton channel activity", "Proton transmembrane transporter activity", "Proton transporting atp synthase activity rotational mechanism", "Pseudouridine synthase activity", "Purine nucleotide transmembrane transporter activity", "Pyrimidine nucleotide binding", "Pyrimidine nucleotide sugar transmembrane transporter activity", "Pyrophosphate hydrolysis driven proton transmembrane transporter activity", "Pyruvate dehydrogenase acetyl transferring kinase activity", "Pyruvate dehydrogenase activity", "Pyruvate transmembrane transporter activity", "Quaternary ammonium group binding", "Quaternary ammonium group transmembrane transporter activity", "Quinone binding", "R smad binding", "Racemase and epimerase activity", "Racemase and epimerase activity acting on carbohydrates and derivatives", "Rage receptor binding", "Rdna binding", "Receptor antagonist activity", "Receptor serine threonine kinase binding", "Receptor tyrosine kinase binding", "Regulatory rna binding", "Retinal binding", "Retinal dehydrogenase activity", "Retinoic acid binding", "Retinoic acid receptor binding", "Retinoid x receptor binding", "Retinol binding", "Retromer complex binding", "Ribonuclease activity", "Ribonuclease p activity", "Ribonuclease p rna binding", "Ribonucleoprotein complex binding", "Ribonucleotide binding", "Ribose phosphate diphosphokinase activity", "Ribosomal large subunit binding", "Ribosomal protein s6 kinase activity", "Ribosomal small subunit binding", "Ribosome binding", "Rna 2 o methyltransferase activity", "Rna 7 methylguanosine cap binding", "Rna adenylyltransferase activity", "Rna binding", "Rna binding involved in posttranscriptional gene silencing", "Rna cap binding", "Rna directed dna polymerase activity", "Rna dna hybrid ribonuclease activity", "Rna methyltransferase activity", "Rna polymerase activity", "Rna polymerase binding", "Rna polymerase core enzyme binding", "Rna polymerase i general transcription initiation factor activity", "Rna polymerase i transcription regulatory region sequence specific dna binding", "Rna polymerase ii activity", "Rna polymerase ii c terminal domain binding", "Rna polymerase ii c terminal domain phosphoserine binding", "Rna polymerase ii core promoter sequence specific dna binding", "Rna polymerase ii ctd heptapeptide repeat kinase activity", "Rna polymerase ii general transcription initiation factor activity", "Rna polymerase ii general transcription initiation factor binding", "Rna polymerase ii specific dna binding transcription factor binding", "Rna polymerase iii transcription regulatory region sequence specific dna binding", "Rna stem loop binding", "Rna strand annealing activity", "Roundabout binding", "Rrna adenine methyltransferase activity", "Rrna binding", "Rrna cytosine methyltransferase activity", "S acyltransferase activity", "S adenosyl l methionine binding", "S adenosylmethionine dependent methyltransferase activity", "S methyltransferase activity", "S100 protein binding", "Salt transmembrane transporter activity", "Scaffold protein binding", "Scavenger receptor activity", "Secondary active transmembrane transporter activity", "Semaphorin receptor activity", "Sequence specific dna binding", "Sequence specific mrna binding", "Sequence specific single stranded dna binding", "Serine hydrolase activity", "Serine transmembrane transporter activity", "Serine type carboxypeptidase activity", "Serine type endopeptidase inhibitor activity", "Serine type exopeptidase activity", "Sh2 domain binding", "Sh3 domain binding", "Signal recognition particle binding", "Signal sequence binding", "Signaling adaptor activity", "Signaling receptor binding", "Signaling receptor complex adaptor activity", "Signaling receptor inhibitor activity", "Signaling receptor regulator activity", "Single stranded dna 3 5 exodeoxyribonuclease activity", "Single stranded dna binding", "Single stranded dna endodeoxyribonuclease activity", "Single stranded dna exodeoxyribonuclease activity", "Single stranded dna helicase activity", "Single stranded rna binding", "Single stranded telomeric dna binding", "Sirna binding", "Smad binding", "Small molecule sensor activity", "Small protein activating enzyme binding", "Small ribosomal subunit rrna binding", "Snap receptor activity", "Snare binding", "Snorna binding", "Snrna binding", "Snrnp binding", "Sodium channel inhibitor activity", "Sodium channel regulator activity", "Sodium chloride symporter activity", "Sodium ion binding", "Sodium ion transmembrane transporter activity", "Solute anion antiporter activity", "Solute cation antiporter activity", "Solute cation symporter activity", "Solute proton antiporter activity", "Solute proton symporter activity", "Solute sodium symporter activity", "Spectrin binding", "Sphingolipid binding", "Sphingolipid transfer activity", "Sphingolipid transporter activity", "Sphingomyelin phosphodiesterase activity", "Sphingosine n acyltransferase activity", "Stat family protein binding", "Steroid binding", "Steroid dehydrogenase activity", "Steroid dehydrogenase activity acting on the ch oh group of donors nad or nadp as acceptor", "Steroid hormone binding", "Steroid hormone receptor activity", "Sterol binding", "Sterol esterase activity", "Sterol transfer activity", "Sterol transporter activity", "Structural constituent of cytoskeleton", "Structural constituent of eye lens", "Structural constituent of muscle", "Structural constituent of nuclear pore", "Structural constituent of postsynapse", "Structural constituent of postsynaptic actin cytoskeleton", "Structural constituent of presynaptic active zone", "Structural constituent of ribosome", "Structural constituent of synapse", "Structural molecule activity", "Structural molecule activity conferring elasticity", "Succinate transmembrane transporter activity", "Sulfate binding", "Sulfate transmembrane transporter activity", "Sulfatide binding", "Sulfotransferase activity", "Sulfur compound binding", "Sulfur compound transmembrane transporter activity", "Sulfuric ester hydrolase activity", "Sulfurtransferase activity", "Sumo binding", "Sumo ligase activity", "Sumo specific protease activity", "Sumo transferase activity", "Supercoiled dna binding", "Superoxide dismutase activity", "Symporter activity", "Syntaxin 1 binding", "Syntaxin binding", "T cell receptor binding", "Tap binding", "Tap1 binding", "Tat protein binding", "Tau protein binding", "Tau protein kinase activity", "Tbp class protein binding", "Telomerase activity", "Telomerase inhibitor activity", "Telomerase rna binding", "Telomeric dna binding", "Testosterone dehydrogenase nad p activity", "Testosterone dehydrogenase nadplus activity", "Tetrapyrrole binding", "Tfiib class transcription factor binding", "Tfiid class transcription factor complex binding", "Thiamine pyrophosphate binding", "Thioesterase binding", "Thiol oxidase activity", "Thiolester hydrolase activity", "Thioredoxin disulfide reductase activity", "Threonine type endopeptidase activity", "Threonine type peptidase activity", "Thyroid hormone receptor binding", "Toxic substance binding", "Tpr domain binding", "Transcription coactivator activity", "Transcription coactivator binding", "Transcription coregulator activity", "Transcription coregulator binding", "Transcription corepressor activity", "Transcription corepressor binding", "Transcription elongation regulator activity", "Transcription factor binding", "Transcription regulator activity", "Transcription regulator inhibitor activity", "Transferase activity transferring alkyl or aryl other than methyl groups", "Transferase activity transferring nitrogenous groups", "Transferase activity transferring one carbon groups", "Transferase activity transferring phosphorus containing groups", "Transferase activity transferring sulphur containing groups", "Transferrin receptor binding", "Transforming growth factor beta receptor binding", "Transition metal ion binding", "Transition metal ion transmembrane transporter activity", "Transketolase or transaldolase activity", "Translation activator activity", "Translation elongation factor activity", "Translation factor activity rna binding", "Translation initiation factor activity", "Translation initiation factor binding", "Translation regulator activity", "Translation regulator activity nucleic acid binding", "Translation repressor activity", "Translation repressor activity mrna regulatory element binding", "Translation termination factor activity", "Transmembrane receptor protein kinase activity", "Transmembrane receptor protein phosphatase activity", "Transmembrane receptor protein tyrosine kinase activity", "Transmembrane transporter binding", "Transporter activity", "Triglyceride lipase activity", "Tripeptide transmembrane transporter activity", "Trna binding", "Trna cytosine methyltransferase activity", "Trna guanine methyltransferase activity", "Trna methyltransferase activity", "Trna specific adenosine deaminase activity", "Trna specific ribonuclease activity", "Tropomyosin binding", "Tubulin binding", "Tumor necrosis factor activated receptor activity", "Tumor necrosis factor binding", "Tumor necrosis factor receptor binding", "Tumor necrosis factor receptor superfamily binding", "Type i transforming growth factor beta receptor binding", "U1 snrna binding", "U2 snrna binding", "U3 snorna binding", "U4 snrna binding", "U6 snrna binding", "Ubiquinol cytochrome c reductase activity", "Ubiquinone binding", "Ubiquitin binding", "Ubiquitin conjugating enzyme binding", "Ubiquitin ligase substrate adaptor activity", "Ubiquitin like modifier activating enzyme activity", "Ubiquitin like protein binding", "Ubiquitin like protein conjugating enzyme activity", "Ubiquitin like protein conjugating enzyme binding", "Ubiquitin like protein ligase activity", "Ubiquitin like protein ligase binding", "Ubiquitin like protein specific isopeptidase activity", "Ubiquitin like protein specific protease activity", "Ubiquitin like protein transferase activity", "Ubiquitin protein transferase activator activity", "Ubiquitin protein transferase inhibitor activity", "Ubiquitin protein transferase regulator activity", "Ubiquitin specific protease binding", "Ubiquitin ubiquitin ligase activity", "Ubiquitination like modification dependent protein binding", "Udp galactose beta n acetylglucosamine beta 1 3 galactosyltransferase activity", "Udp glucosyltransferase activity", "Udp glycosyltransferase activity", "Udp xylosyltransferase activity", "Unfolded protein binding", "Unmethylated cpg binding", "Uridylyltransferase activity", "Vascular endothelial growth factor activated receptor activity", "Vascular endothelial growth factor binding", "Vascular endothelial growth factor receptor 2 binding", "Vascular endothelial growth factor receptor binding", "Very long chain fatty acid coa ligase activity", "Vinculin binding", "Virion binding", "Vitamin b6 binding", "Vitamin binding", "Vitamin d binding", "Vitamin d receptor binding", "Vitamin transmembrane transporter activity", "Voltage gated anion channel activity", "Voltage gated calcium channel activity", "Voltage gated calcium channel activity involved in regulation of cytosolic calcium levels", "Voltage gated cation channel activity", "Voltage gated channel activity", "Voltage gated chloride channel activity", "Volume sensitive anion channel activity", "Water channel activity", "Water transmembrane transporter activity", "Wd40 repeat domain binding", "Wide pore channel activity", "Wnt protein binding", "Ww domain binding", "Xenobiotic transmembrane transporter activity", "Y form dna binding", "Zinc ion binding", "Zinc ion transmembrane transporter activity"], "available_proteins": ["AARS", "AARS2", "AASDHPPT", "AASS", "AATF", "ABCB1", "ABCB10", "ABCB6", "ABCB7", "ABCB8", "ABCC4", "ABCD3", "ABCE1", "ABCF1", "ABCF2", "ABCF3", "ABHD10", "ABHD12", "ABHD6", "ABRAXAS2", "ACAA1", "ACAA2", "ACACA", "ACACB", "ACAD11", "ACAD9", "ACADM", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACBD5", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT8", "ACOT9", "ACOX1", "ACOX3", "ACP1", "ACP2", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACSL6", "ACTL6A", "ACTN1", "ACTN4", "ACTR1A", "ACTR1B", "ACTR2", "ACTR3", "ACTR8", "ADA", "ADAR", "ADD1", "ADD3", "ADH5", "ADI1", "ADK", "ADNP", "ADPGK", "ADRM1", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGK", "AGL", "AGPAT1", "AGPAT5", "AGPS", "AHCY", "AHCYL1", "AHNAK", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AK3", "AK4", "AK6", "AKAP1", "AKAP10", "AKAP8", "AKAP8L", "AKAP9", "AKR1A1", "AKR1B1", "AKR7A2", "AKT2", "ALDH16A1", "ALDH18A1", "ALDH1A2", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALG1", "ALG11", "ALG5", "ALKBH5", "ALYREF", "AMOT", "ANAPC1", "ANAPC2", "ANAPC4", "ANAPC5", "ANAPC7", "ANGEL1", "ANK3", "ANKFY1", "ANKHD1", "ANKLE2", "ANKRD17", "ANLN", "ANO10", "ANO6", "ANP32A", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA4", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP1M1", "AP1S1", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3M1", "APEH", "APEX1", "API5", "APMAP", "APP", "APPL1", "APRT", "AQR", "ARCN1", "ARF4", "ARF6", "ARFGAP1", "ARFIP1", "ARFIP2", "ARG2", "ARGLU1", "ARHGAP17", "ARHGDIA", "ARHGEF2", "ARID1A", "ARIH2", "ARL1", "ARL2", "ARL3", "ARL6IP1", "ARL8A", "ARMT1", "ARPC1A", "ARPC2", "ARPC3", "ARPC4", "ARVCF", "ASAH1", "ASCC2", "ASCC3", "ASH2L", "ASNA1", "ASNS", "ASPH", "ATAD1", "ATAD2", "ATAD3A", "ATAD3B", "ATAD5", "ATG3", "ATG9A", "ATIC", "ATL2", "ATP13A1", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP2B4", "ATP2C1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6AP1", "ATP6AP2", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1D", "ATP6V1E1", "ATP6V1H", "ATP7A", "ATP7B", "ATPIF1", "ATRIP", "ATXN2L", "AUP1", "AURKA", "B3GALT6", "B4GAT1", "BABAM2", "BAG2", "BAG3", "BAG4", "BAG5", "BAG6", "BAIAP2", "BANF1", "BAP18", "BARD1", "BASP1", "BAZ1A", "BAZ1B", "BAZ2A", "BCAP31", "BCAS3", "BCCIP", "BCKDK", "BCLAF1", "BCR", "BCS1L", "BICD2", "BIRC6", "BLM", "BLMH", "BLVRA", "BMS1", "BNIP1", "BOLA2*", "BOP1", "BPNT1", "BPTF", "BRAP", "BRCA1", "BRD1", "BRD2", "BRD4", "BRIX1", "BRMS1L", "BSG", "BTAF1", "BTF3", "BUB1B", "BUB3", "BUD23", "BUD31", "BYSL", "BZW1", "BZW2", "C1QBP", "C1orf123", "C1orf35", "C2CD5", "CAB39", "CACYBP", "CAD", "CALD1", "CALR", "CALU", "CAMK2G", "CAMSAP3", "CAND1", "CAND2", "CANT1", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPNS1", "CAPRIN1", "CAPZA1", "CAPZB", "CARHSP1", "CARS", "CASK", "CAST", "CBR1", "CBX1", "CBX2", "CBX3", "CBX5", "CBX8", "CC2D1A", "CCAR1", "CCAR2", "CCDC22", "CCDC47", "CCDC59", "CCDC6", "CCDC86", "CCNB1", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2AP", "CD2BP2", "CD3EAP", "CD47", "CDC23", "CDC27", "CDC37", "CDC42", "CDC5L", "CDC73", "CDCA5", "CDH2", "CDIPT", "CDK1", "CDK12", "CDK2", "CDK4", "CDK5", "CDK5RAP1", "CDK5RAP3", "CDK6", "CDK9", "CDKAL1", "CDKN2A", "CDKN2AIP", "CDS2", "CEBPZ", "CELF1", "CELF2", "CENPB", "CENPV", "CEP44", "CEP55", "CERS2", "CERS5", "CETN2", "CFAP20", "CFL1", "CFL2", "CHAC2", "CHAF1A", "CHAF1B", "CHAMP1", "CHCHD3", "CHD1", "CHD1L", "CHD4", "CHD8", "CHDH", "CHERP", "CHID1", "CHKA", "CHMP2B", "CHMP3", "CHMP4B", "CHMP5", "CHORDC1", "CHRAC1", "CHST14", "CHTF18", "CHTOP", "CIAPIN1", "CIB1", "CIP2A", "CIRBP", "CISD2", "CIT", "CIZ1", "CKAP4", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLASP2", "CLCC1", "CLCN3", "CLCN7", "CLGN", "CLIC1", "CLINT1", "CLN5", "CLNS1A", "CLPB", "CLPP", "CLPX", "CLSPN", "CLTA", "CLTB", "CLTC", "CLUH", "CMAS", "CMPK1", "CMTR1", "CNDP2", "CNN2", "CNN3", "CNNM3", "CNNM4", "CNOT1", "CNOT4", "CNOT9", "CNP", "COG2", "COIL", "COL4A3BP", "COLEC12", "COLGALT1", "COMT", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS2", "COPS4", "COPS5", "COPS6", "COQ8A", "COQ9", "CORO1B", "CORO1C", "CORO7", "COTL1", "COX15", "COX18", "COX2", "COX4I1", "COX5A", "COX5B", "COX7A2", "COX7A2L", "CPD", "CPNE1", "CPNE2", "CPNE3", "CPNE8", "CPOX", "CPSF1", "CPSF2", "CPSF3", "CPSF6", "CPSF7", "CPT1A", "CPT2", "CPVL", "CRK", "CRKL", "CRNKL1", "CRTAP", "CRYZ", "CS", "CSDE1", "CSE1L", "CSGALNACT2", "CSK", "CSNK1A1", "CSNK2A1", "CSNK2A2", "CSNK2B", "CSRP2", "CSTB", "CSTF1", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTNNA1", "CTNNAL1", "CTNNB1", "CTNND1", "CTPS1", "CTPS2", "CTR9", "CTSA", "CTSC", "CTTN", "CTTNBP2NL", "CTU2", "CUL1", "CUL2", "CUL3", "CUL4A", "CUL4B", "CUL5", "CUTA", "CWC15", "CWC22", "CWF19L1", "CXADR", "CXorf57", "CYB5B", "CYB5R1", "CYB5R3", "CYC1", "CYFIP1", "CYFIP2", "CYP20A1", "CYP51A1", "DAGLB", "DAP3", "DARS", "DARS2", "DAZAP1", "DBN1", "DBNL", "DBT", "DCAF1", "DCAF13", "DCAF7", "DCAKD", "DCD", "DCP1B", "DCPS", "DCTD", "DCTN1", "DCTN2", "DCTN3", "DCTN4", "DCTPP1", "DCUN1D1", "DCUN1D5", "DCXR", "DDB1", "DDI2", "DDOST", "DDRGK1", "DDT", "DDX1", "DDX10", "DDX17", "DDX18", "DDX20", "DDX21", "DDX23", "DDX24", "DDX27", "DDX28", "DDX39A", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX50", "DDX51", "DDX52", "DDX54", "DDX56", "DDX6", "DEK", "DENND6A", "DENR", "DERL1", "DERL2", "DFFA", "DHCR24", "DHCR7", "DHFR", "DHPS", "DHRS1", "DHRS13", "DHRS7", "DHRS7B", "DHTKD1", "DHX15", "DHX16", "DHX29", "DHX30", "DHX36", "DHX37", "DHX38", "DHX40", "DHX57", "DHX8", "DHX9", "DIAPH1", "DIAPH2", "DIAPH3", "DICER1", "DIDO1", "DIEXF", "DIMT1", "DIS3", "DKC1", "DLAT", "DLD", "DLG1", "DLGAP5", "DLST", "DMAP1", "DNA2", "DNAAF5", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJC1", "DNAJC10", "DNAJC2", "DNAJC21", "DNAJC3", "DNAJC7", "DNAJC8", "DNAJC9", "DNM1L", "DNM2", "DNMT1", "DNPH1", "DNTTIP2", "DOCK7", "DOHH", "DOLPP1", "DPF2", "DPH2", "DPH5", "DPM1", "DPP3", "DPP9", "DPY30", "DPYSL2", "DPYSL3", "DPYSL5", "DRG1", "DRG2", "DSC3", "DSG2", "DSP", "DST", "DSTN", "DTX3L", "DTYMK", "DUS2", "DUSP12", "DUSP3", "DUSP9", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNC2H1", "DYNLL1", "DYNLL2", "EARS2", "EBNA1BP2", "EBP", "ECE1", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "EDC3", "EDF1", "EEA1", "EEF1A2", "EEF1B2", "EEF1D", "EEF1G", "EEF2", "EFCAB14", "EFL1", "EFTUD2", "EHD1", "EHD4", "EI24", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2D", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E", "EIF4E2", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAC2", "ELAVL1", "ELL", "ELMO2", "ELMOD2", "ELOB", "ELP1", "ELP2", "ELP3", "ELP4", "EMC1", "EMC2", "EMC7", "EMD", "EMG1", "EML4", "ENAH", "ENDOD1", "ENO1", "ENO2", "ENY2", "EP400", "EPB41", "EPB41L2", "EPB41L3", "EPB41L5", "EPDR1", "EPHA7", "EPHX1", "EPHX2", "EPN1", "EPPK1", "EPRS", "EPS15L1", "ERAL1", "ERAP1", "ERAP2", "ERBIN", "ERC1", "ERCC2", "ERCC3", "ERCC6L", "ERG28", "ERGIC3", "ERH", "ERLIN1", "ERLIN2", "ERMP1", "ERO1A", "ERO1B", "ERP29", "ESD", "ESF1", "ESYT1", "ESYT2", "ETF1", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXD2", "EXO1", "EXOC2", "EXOC3", "EXOC5", "EXOC8", "EXOSC1", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC8", "EXOSC9", "EYA4", "EZR", "F11R", "FADS2", "FAF1", "FAF2", "FAHD1", "FAHD2A", "FAM120A", "FAM129B", "FAM208A", "FAM213A", "FAM49B", "FAM50A", "FAM98A", "FAM98B", "FANCD2", "FANCI", "FAR1", "FARP1", "FARP2", "FARSA", "FARSB", "FASN", "FASTKD5", "FAU", "FBL", "FDFT1", "FDPS", "FDXR", "FECH", "FEN1", "FERMT2", "FGFR1OP", "FH", "FHL1", "FHOD1", "FIP1L1", "FIS1", "FKBP10", "FKBP14", "FKBP2", "FKBP3", "FKBP4", "FKBP5", "FKBP7", "FKBP8", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FMR1", "FNDC3A", "FNTA", "FNTB", "FOXC1", "FOXK1", "FOXRED1", "FSCN1", "FSD1", "FTO", "FTSJ3", "FUBP1", "FUBP3", "FUCA1", "FUCA2", "FUNDC2", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GAK", "GALK1", "GALM", "GALNS", "GALNT1", "GALNT2", "GALNT4", "GALNT7", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GATAD2B", "GATB", "GBA", "GBF1", "GCAT", "GCDH", "GCLC", "GCN1", "GDI1", "GDI2", "GDPD1", "GEMIN4", "GEMIN5", "GET4", "GFM1", "GFPT1", "GGA1", "GGCT", "GGCX", "GGH", "GGT7", "GHDC", "GID4", "GIGYF2", "GLA", "GLB1", "GLCE", "GLDC", "GLE1", "GLG1", "GLMN", "GLO1", "GLOD4", "GLRX3", "GLRX5", "GLS", "GLTP", "GLUD1", "GLYR1", "GM2A", "GMFB", "GMPS", "GNA13", "GNAI1", "GNAI2", "GNAI3", "GNAQ", "GNE", "GNG12", "GNG5", "GNL1", "GNL2", "GNL3", "GNL3L", "GNPAT", "GNPDA1", "GNPNAT1", "GNS", "GOLGA2", "GOLGA3", "GOLGA5", "GOLGB1", "GOSR1", "GOT1", "GOT2", "GPAA1", "GPAM", "GPAT4", "GPATCH4", "GPATCH8", "GPD1L", "GPD2", "GPHN", "GPI", "GPKOW", "GPR107", "GPR89B", "GPRASP2", "GPS1", "GPT2", "GPX8", "GRB2", "GRHPR", "GRPEL1", "GRSF1", "GRWD1", "GSK3B", "GSPT1", "GSR", "GSS", "GSTK1", "GSTM3", "GSTO1", "GSTZ1", "GTF2E1", "GTF2E2", "GTF2F1", "GTF2H1", "GTF2H4", "GTF2I", "GTF3C4", "GTPBP1", "GTPBP10", "GTPBP3", "GTPBP4", "GUF1", "GXYLT1", "GYG1", "GYS1", "H1F0", "H1FX", "H2AFY", "H2AFY2", "H4C1*", "HACD3", "HACL1", "HADH", "HADHA", "HADHB", "HARS2", "HAT1", "HAUS4", "HAUS6", "HAX1", "HBS1L", "HCCS", "HCFC1", "HDAC1", "HDAC2", "HDGF", "HDGFL2", "HDGFL3", "HDHD2", "HDLBP", "HEATR1", "HEATR3", "HEATR6", "HEBP1", "HECTD1", "HECTD3", "HELLS", "HEXA", "HEXB", "HGS", "HIBADH", "HIBCH", "HINT2", "HINT3", "HIRA", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLTF", "HM13", "HMBS", "HMCES", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMGCL", "HMGCR", "HMGCS1", "HMGN2", "HMMR", "HMOX1", "HMOX2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPLL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HNRNPUL2", "HOOK2", "HOOK3", "HP1BP3", "HPRT1", "HPS6", "HS2ST1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSD17B7", "HSDL1", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA13", "HSPA14", "HSPA1B", "HSPA2", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPBP1", "HSPD1", "HSPE1", "HSPH1", "HTATSF1", "HTT", "HUWE1", "HYOU1", "IARS", "IARS2", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDH3G", "IDI1", "IFIT5", "IFT27", "IFT81", "IGBP1", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IK", "IKBKB", "ILF2", "ILF3", "ILK", "ILKAP", "ILVBL", "IMMT", "IMP3", "IMP4", "IMPAD1", "IMPDH1", "IMPDH2", "INA", "INF2", "INPP4A", "INPPL1", "INTS11", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQCB1", "IQGAP1", "IQGAP3", "IRF2BPL", "IRGQ", "IRS4", "ISG20L2", "IST1", "ISY1", "ISYNA1", "ITCH", "ITGB1", "ITM2C", "ITPA", "ITPK1", "ITSN2", "IVD", "JMJD6", "JUP", "KARS", "KAT7", "KCTD12", "KDELC2", "KDELR1", "KDM1A", "KDM1B", "KDM2A", "KDM3B", "KDM5A", "KDSR", "KHDRBS1", "KHDRBS3", "KHSRP", "KIAA0368", "KIAA0391", "KIAA1147", "KIDINS220", "KIF11", "KIF14", "KIF18A", "KIF18B", "KIF1A", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF3A", "KIF4A", "KIF5B", "KIFBP", "KIN", "KLC1", "KMT2A", "KNOP1", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNA6", "KPNB1", "KRI1", "KRR1", "KTN1", "KYAT3", "L2HGDH", "L3HYPDH", "LACTB", "LAMB1", "LAMC1", "LAMP1", "LAMP2", "LAMTOR1", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LAS1L", "LASP1", "LBR", "LCLAT1", "LDAH", "LDHA", "LDHB", "LDLR", "LEMD3", "LETM1", "LGALS3", "LGALS3BP", "LGMN", "LIG1", "LIG3", "LIMA1", "LIPA", "LLGL1", "LLPH", "LMAN2", "LMAN2L", "LMNB1", "LMNB2", "LNPEP", "LNPK", "LONP1", "LPCAT1", "LPGAT1", "LRBA", "LRP1", "LRPAP1", "LRPPRC", "LRRC40", "LRRC47", "LRRC59", "LRRC8C", "LRSAM1", "LRWD1", "LSM14B", "LSM2", "LSM4", "LSM6", "LSM7", "LSS", "LTA4H", "LTN1", "LUC7L", "LUC7L2", "LUC7L3", "LYAR", "LYN", "LYPLA1", "LZTFL1", "M6PR", "MACF1", "MAEA", "MAGT1", "MAIP1", "MAK16", "MALT1", "MAN2A1", "MAN2B1", "MANF", "MAP1A", "MAP1B", "MAP1S", "MAP4", "MAPK1", "MAPK14", "MAPRE1", "MAPRE2", "MARC1", "MARCH5", "MARS", "MARS2", "MAT2A", "MAT2B", "MATR3", "MAU2", "MAVS", "MBD3", "MBOAT7", "MCCC1", "MCCC2", "MCL1", "MCM10", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCMBP", "MCU", "MCUB", "MDC1", "MDH1", "MDH2", "MDN1", "ME1", "ME2", "MECP2", "MED14", "MED17", "MED22", "MED23", "MED24", "MED4", "MEPCE", "MESD", "METAP1", "METAP2", "METTL13", "METTL3", "METTL7B", "METTL9", "MFN1", "MFN2", "MFSD10", "MFSD3", "MFSD5", "MGEA5", "MGST2", "MGST3", "MIA3", "MICU1", "MIEF1", "MIF", "MIGA1", "MINDY3", "MINPP1", "MIPEP", "MKI67", "MKLN1", "MKRN2", "MLEC", "MMAB", "MMS19", "MOCOS", "MOGS", "MORC2", "MORF4L1", "MOV10", "MPC2", "MPG", "MPHOSPH10", "MPHOSPH6", "MPHOSPH8", "MPI", "MPP1", "MPP2", "MPP7", "MPRIP", "MPST", "MPV17", "MRC2", "MRE11", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL14", "MRPL15", "MRPL17", "MRPL19", "MRPL2", "MRPL20", "MRPL21", "MRPL22", "MRPL24", "MRPL28", "MRPL3", "MRPL37", "MRPL39", "MRPL40", "MRPL41", "MRPL43", "MRPL44", "MRPL45", "MRPL46", "MRPL47", "MRPL49", "MRPL58", "MRPL9", "MRPS11", "MRPS16", "MRPS18A", "MRPS22", "MRPS23", "MRPS25", "MRPS27", "MRPS28", "MRPS30", "MRPS31", "MRPS33", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRPS9", "MRRF", "MRTO4", "MSH2", "MSH3", "MSH6", "MSI1", "MSI2", "MSMO1", "MSN", "MTA1", "MTA2", "MTAP", "MTCH1", "MTDH", "MTHFD1", "MTHFD1L", "MTHFD2", "MTHFS", "MTMR14", "MTMR2", "MTMR6", "MTO1", "MTOR", "MTPAP", "MTPN", "MTR", "MUL1", "MUT", "MVD", "MYBBP1A", "MYCBP", "MYCBP2", "MYEF2", "MYG1", "MYH10", "MYH14", "MYH9", "MYL6", "MYO18A", "MYO1B", "MYO1C", "MYO1D", "MYO6", "NAA10", "NAA15", "NAA25", "NAA40", "NAA50", "NAE1", "NAF1", "NAGLU", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NAPG", "NARS", "NASP", "NAT10", "NAXE", "NBAS", "NBN", "NCAPD2", "NCAPD3", "NCAPG", "NCAPG2", "NCAPH", "NCBP1", "NCBP3", "NCEH1", "NCKAP1", "NCKIPSD", "NCL", "NCLN", "NCOA5", "NCOR1", "NCSTN", "ND1", "NDC1", "NDC80", "NDUFA10", "NDUFA13", "NDUFA4", "NDUFA5", "NDUFA7", "NDUFA8", "NDUFA9", "NDUFAF2", "NDUFAF4", "NDUFAF7", "NDUFB10", "NDUFB3", "NDUFB4", "NDUFB5", "NDUFB6", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS6", "NDUFS7", "NDUFS8", "NDUFV1", "NDUFV2", "NEDD4L", "NEFL", "NEFM", "NEK9", "NELFA", "NELFB", "NELFCD", "NELFE", "NEMF", "NENF", "NES", "NF1", "NFS1", "NFU1", "NFXL1", "NHP2", "NIFK", "NIP7", "NIPBL", "NIPSNAP1", "NISCH", "NIT2", "NKRF", "NKTR", "NLN", "NLRX1", "NME1", "NME2", "NMT1", "NNT", "NOA1", "NOB1", "NOC2L", "NOC3L", "NOC4L", "NOL10", "NOL11", "NOL6", "NOL7", "NOL8", "NOL9", "NOLC1", "NOM1", "NONO", "NOP14", "NOP16", "NOP2", "NOP53", "NOP56", "NOP58", "NOP9", "NOSIP", "NOTCH2", "NPC1", "NPC2", "NPEPPS", "NPLOC4", "NPM1", "NRBP1", "NRDC", "NRP1", "NSA2", "NSD1", "NSD2", "NSD3", "NSDHL", "NSF", "NSMCE2", "NSUN2", "NT5C2", "NT5C3A", "NT5C3B", "NT5DC1", "NT5DC2", "NTHL1", "NTMT1", "NTPCR", "NUBP2", "NUBPL", "NUCB1", "NUCB2", "NUCKS1", "NUDC", "NUDCD2", "NUDCD3", "NUDT1", "NUDT16L1", "NUDT21", "NUDT5", "NUF2", "NUFIP2", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP160", "NUP188", "NUP205", "NUP214", "NUP35", "NUP54", "NUP58", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NUPL2", "NUSAP1", "NUTF2", "NVL", "NXF1", "NXN", "OARD1", "OAT", "OCLN", "OCRL", "OGDH", "OGFOD3", "OGT", "OLA1", "OPA1", "ORC2", "ORC3", "ORC5", "OSBP", "OSBPL11", "OSBPL1A", "OSBPL6", "OSBPL8", "OSBPL9", "OSGEP", "OSTF1", "OTUB1", "OXA1L", "OXSR1", "P3H1", "P3H4", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PAF1", "PAFAH1B1", "PAFAH1B2", "PAFAH1B3", "PAICS", "PAK2", "PALD1", "PALLD", "PANK4", "PAPOLA", "PAPSS1", "PARD3", "PARG", "PARK7", "PARN", "PARP1", "PARP2", "PATL1", "PBK", "PBRM1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCM1", "PCMT1", "PCNA", "PCYOX1", "PDAP1", "PDCD11", "PDCD5", "PDCD6", "PDCD6IP", "PDCL3", "PDE12", "PDHA1", "PDHB", "PDHX", "PDIA3", "PDIA4", "PDIA6", "PDK1", "PDK3", "PDLIM1", "PDLIM5", "PDP1", "PDSS2", "PDXDC1", "PDZD8", "PEBP1", "PECR", "PEF1", "PELO", "PELP1", "PEPD", "PES1", "PEX11B", "PEX14", "PEX19", "PEX3", "PFAS", "PFDN2", "PFDN4", "PFDN5", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGM3", "PGP", "PGRMC1", "PGRMC2", "PHB", "PHB2", "PHF10", "PHF2", "PHF5A", "PHF6", "PHGDH", "PHIP", "PHKA1", "PHKB", "PI4K2A", "PI4KA", "PI4KB", "PICALM", "PIGG", "PIGK", "PIGU", "PIH1D1", "PIK3C2A", "PIK3R2", "PIK3R4", "PIN1", "PIN4", "PINX1", "PIP4K2C", "PIR", "PISD", "PITPNA", "PITPNB", "PITRM1", "PKM", "PKMYT1", "PKN1", "PKN2", "PLA2G15", "PLAA", "PLBD2", "PLCG1", "PLD3", "PLD6", "PLEC", "PLEKHA5", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLS3", "PLXNB2", "PM20D2", "PMPCA", "PMPCB", "PMVK", "PNKP", "PNN", "PNO1", "PNP", "PNPLA6", "PNPLA8", "PNPT1", "POFUT1", "POLA1", "POLD1", "POLDIP2", "POLDIP3", "POLE", "POLE2", "POLG", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2A", "POLR2B", "POLR2C", "POLR2D", "POLR2E", "POLR2G", "POLR2L", "POLR3A", "POLR3B", "POLR3C", "POLRMT", "PON2", "POP1", "POP4", "POR", "PPA1", "PPA2", "PPAN", "PPAT", "PPCDC", "PPHLN1", "PPIB", "PPIC", "PPID", "PPIE", "PPIF", "PPIG", "PPIH", "PPIL4", "PPM1G", "PPME1", "PPOX", "PPP1CA", "PPP1CB", "PPP1R10", "PPP1R7", "PPP1R8", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP2R5E", "PPP3CA", "PPP4R1", "PPP4R3A", "PPP5C", "PPP6C", "PPP6R3", "PPT1", "PPWD1", "PQBP1", "PRC1", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PREP", "PREPL", "PRIM1", "PRIM2", "PRKAA1", "PRKAA2", "PRKACA", "PRKAG1", "PRKAR1A", "PRKAR2A", "PRKCB", "PRKCSH", "PRKDC", "PRMT1", "PRMT3", "PRMT5", "PRMT9", "PRPF19", "PRPF3", "PRPF31", "PRPF38B", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPS2", "PRPSAP1", "PRPSAP2", "PRRC1", "PRRC2A", "PRRC2B", "PRRC2C", "PSAP", "PSAT1", "PSIP1", "PSMA1", "PSMA3", "PSMA4", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD6", "PSMD7", "PSME1", "PSME2", "PSME3", "PSME4", "PSMG1", "PSMG2", "PSMG3", "PSPC1", "PTBP1", "PTBP2", "PTCD1", "PTCD3", "PTDSS1", "PTDSS2", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK2", "PTK7", "PTPA", "PTPN1", "PTPN11", "PTPN23", "PTPRF", "PTRH2", "PUF60", "PUM3", "PURA", "PUS1", "PUS7", "PUS7L", "PWP1", "PWP2", "PXN", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QDPR", "QKI", "QRSL1", "QSOX2", "QTRT2", "RAB10", "RAB12", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB1B", "RAB23", "RAB24", "RAB2A", "RAB34", "RAB35", "RAB3B", "RAB3GAP1", "RAB3GAP2", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RAB8A", "RAB9A", "RABGAP1", "RABGGTA", "RABL3", "RABL6", "RAC1", "RACGAP1", "RACK1", "RAD18", "RAD21", "RAD23A", "RAD23B", "RAD50", "RAD54L2", "RAE1", "RAI14", "RALA", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP6", "RANBP9", "RANGAP1", "RAP1GDS1", "RAPGEF2", "RARS", "RARS2", "RAVER1", "RBBP4", "RBBP5", "RBBP6", "RBBP7", "RBM10", "RBM12", "RBM12B", "RBM14", "RBM17", "RBM19", "RBM22", "RBM25", "RBM26", "RBM27", "RBM28", "RBM3", "RBM34", "RBM39", "RBM4", "RBM45", "RBM47", "RBM5", "RBM6", "RBM8A", "RBMX", "RBMXL1", "RBPJ", "RCC1", "RCC2", "RCL1", "RCN1", "RCN2", "RDH11", "RDH13", "RDH14", "RDX", "RECQL", "REEP4", "RER1", "RETSAT", "REXO2", "REXO4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RFT1", "RHBDD2", "RHEB", "RHOG", "RHOT1", "RHOT2", "RIDA", "RIPK1", "RMDN1", "RMDN3", "RNASEH2A", "RNASET2", "RNF2", "RNF20", "RNF40", "RNMT", "RNPEP", "RNPS1", "ROBO1", "ROCK1", "ROCK2", "RP2", "RPA1", "RPA2", "RPAP1", "RPF1", "RPF2", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPN1", "RPN2", "RPP30", "RPP38", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS26", "RPS28", "RPS29", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RPTOR", "RPUSD3", "RRAS2", "RRBP1", "RREB1", "RRM1", "RRM2", "RRP1", "RRP12", "RRP1B", "RRP36", "RRP8", "RRP9", "RRS1", "RSBN1", "RSF1", "RSL1D1", "RSL24D1", "RSPRY1", "RTCA", "RTCB", "RTN4", "RTN4IP1", "RTRAF", "RUFY1", "RUVBL1", "RUVBL2", "S100A11", "S100A13", "SACM1L", "SAE1", "SAFB", "SAFB2", "SALL2", "SAMD4B", "SAMHD1", "SAP18", "SAR1A", "SAR1B", "SARM1", "SARNP", "SARS", "SARS2", "SART1", "SART3", "SBDS", "SBNO1", "SCAF1", "SCAF11", "SCAF4", "SCAMP1", "SCAMP3", "SCARB1", "SCARB2", "SCCPDH", "SCD", "SCFD1", "SCFD2", "SCML2", "SCO1", "SCO2", "SCP2", "SCPEP1", "SCRIB", "SCRN1", "SCYL1", "SDF4", "SDHA", "SDHB", "SDHC", "SDR39U1", "SEC11A", "SEC22B", "SEC23A", "SEC23B", "SEC23IP", "SEC24A", "SEC24B", "SEC24C", "SEC31A", "SEC61A1", "SEC61B", "SEC62", "SEC63", "SEH1L", "SENP3", "SEPT11", "SEPT2", "SEPT7", "SEPT9", "SERBP1", "SERPINB6", "SERPINH1", "SET", "SETD1A", "SETD2", "SETD3", "SETDB1", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFSWAP", "SFXN1", "SFXN2", "SFXN4", "SGF29", "SGPL1", "SGTA", "SH3GL1", "SH3GLB1", "SHCBP1", "SHMT1", "SHMT2", "SHTN1", "SIGMAR1", "SIN3A", "SKA1", "SKIV2L", "SKIV2L2", "SKP1", "SKP2", "SLC12A2", "SLC12A9", "SLC16A1", "SLC19A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A16", "SLC25A17", "SLC25A19", "SLC25A20", "SLC25A21", "SLC25A24", "SLC25A25", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A33", "SLC25A4", "SLC25A44", "SLC25A5", "SLC25A6", "SLC27A4", "SLC33A1", "SLC35A4", "SLC35B2", "SLC35F2", "SLC39A14", "SLC3A2", "SLC4A1AP", "SLC4A2", "SLC5A6", "SLC7A1", "SLC9A3R1", "SLFN11", "SLIRP", "SLIT2", "SLK", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC5", "SMC6", "SMCHD1", "SMG1", "SMG5", "SMN1*", "SMNDC1", "SMPD4", "SMS", "SND1", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPC", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNU13", "SNW1", "SNX1", "SNX17", "SNX19", "SNX2", "SNX27", "SNX3", "SNX5", "SNX6", "SNX9", "SOAT1", "SOD2", "SON", "SORD", "SORT1", "SPAG5", "SPAG9", "SPART", "SPATA5", "SPATA5L1", "SPATS2L", "SPCS2", "SPCS3", "SPDL1", "SPEN", "SPNS1", "SPOUT1", "SPPL2A", "SPR", "SPTAN1", "SPTBN1", "SPTLC1", "SPTLC2", "SQLE", "SRC", "SRCAP", "SREK1", "SRI", "SRM", "SRP14", "SRP54", "SRP68", "SRP72", "SRP9", "SRPK1", "SRPK2", "SRPRA", "SRPRB", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF3", "SRSF4", "SRSF5", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSRP1", "STAG1", "STAG2", "STAM", "STAM2", "STAT1", "STAT3", "STAU1", "STAU2", "STIP1", "STK26", "STK3", "STK4", "STMN1", "STOM", "STOML2", "STRAP", "STRBP", "STRIP1", "STRN", "STT3A", "STT3B", "STUB1", "STX10", "STX12", "STX16", "STX18", "STX4", "STX7", "STX8", "STXBP2", "STXBP3", "STXBP4", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGP2", "SUGT1", "SUN1", "SUN2", "SUPT16H", "SUPT3H", "SUPT5H", "SUPT6H", "SUPV3L1", "SURF6", "SUZ12", "SV2A", "SYNCRIP", "SYNE1", "SYNE2", "TAB1", "TAF15", "TAF6", "TAGLN2", "TALDO1", "TAMM41", "TAP1", "TAP2", "TARBP1", "TARDBP", "TARS", "TARS2", "TARSL2", "TBC1D13", "TBC1D15", "TBC1D4", "TBC1D9B", "TBCA", "TBCD", "TBCE", "TBL1XR1", "TBL2", "TBL3", "TBRG4", "TCAF1", "TCEA1", "TCERG1", "TCOF1", "TCP1", "TDRKH", "TECR", "TEFM", "TELO2", "TERF2IP", "TES", "TEX264", "TFAM", "TFB1M", "TFCP2", "TFG", "TFRC", "TGFBRAP1", "THAP11", "THOC1", "THOC2", "THOC3", "THOC5", "THOC6", "THOP1", "THRAP3", "THUMPD1", "TIA1", "TIAL1", "TIGAR", "TIMM10B", "TIMM17B", "TIMM23", "TIMM44", "TIMM50", "TIMM8B", "TJP1", "TJP2", "TK1", "TKT", "TLE3", "TLK2", "TLN1", "TMCO1", "TMED10", "TMED9", "TMEM109", "TMEM115", "TMEM192", "TMEM201", "TMEM43", "TMLHE", "TMOD3", "TMPO", "TMPO", "TMTC3", "TMX1", "TMX2", "TMX3", "TNKS1BP1", "TNPO1", "TNPO2", "TNPO3", "TOE1", "TOMM20", "TOMM22", "TOMM34", "TOMM40", "TOMM70", "TOP1", "TOP2A", "TOP2B", "TOPBP1", "TOR1A", 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17.730582524271846 1.450228655394427 0.2143723456093393 2.356374883616516 2.3878203593303375 1.2019998086948689 0.268108115907532 0.02047141811426 0.01497108596825 0.0061250241039257 0.0671599559498881 0.0105883475769395 +Elevated pulmonary artery pressure 12 24 2.654620536352269 0.0079397667667313 7.422330097087379 24.033980582524272 0.8771466934674594 0.3206437689207037 3.083196929894625 3.78086786662344 1.283632173810104 0.3146045769490745 0.0103538868690198 0.3498897642406863 0.0016245798886056 0.0204257314217003 0.0108141130310289 +Macular degeneration 4 15 2.631022395891183 0.0085128425934692 3.5072815533980584 13.201456310679612 0.7081764422831481 0.3007939344006393 1.5711122114355351 1.3240485924903622 1.388921785741595 0.3097317018961461 0.0603420585079261 0.2220822570468345 0.0015259573241502 0.0362911702166911 0.106558868417216 +Supranuclear gaze palsy 6 20 2.63077581272161 0.0085190212011538 5.186893203883495 19.1626213592233 0.8242716574954257 0.3183493558985887 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0.0254745028422094 0.0179874551859817 0.0009115346543113 0.0128775568643314 0.0136567371586889 +Neck muscle weakness 3 16 2.624818559000235 0.0086695152022227 4.206310679611651 15.46359223300971 0.939049769317174 0.3360301393876674 2.1919222801274123 2.3742417714011115 0.9901989764800458 0.2887083620559018 0.0563428561316652 0.2183067054048652 0.0128487417044244 0.0341229578056568 0.1000707214680032 +Ascites 8 24 2.6197604963037846 0.0087991540578369 6.538834951456311 25.800970873786408 0.2860997134153194 0.2561597752608451 2.6559964399945706 3.331112387328855 1.6846905274497244 0.2824645045304154 0.0081664596395861 1.0 0.0047672462644418 0.02815445047553 0.0071079189888272 +Aortic valve stenosis 5 9 2.6100057515445965 0.0090540700386245 2.796116504854369 9.395631067961164 0.7980634307089747 0.2889050866980456 1.488527149166336 2.3205038664019155 1.1792618257802154 0.2672367246557839 0.0076280534495534 1.0 0.0080456420559546 0.0035757213036434 0.0168189007239576 +Hypocholesterolemia 5 8 2.6042501696936275 0.0092075521415719 3.2645631067961167 8.048543689320388 1.205673434171466 0.2055905154190861 1.747510449264718 1.0646904903887575 1.232151298114248 0.2464368010987078 0.0001094986389743 0.0017062060788896 0.0066572828402184 0.0001991597833083 1.6279070379868977e-05 +Abnormal circulating cholesterol concentration 14 34 2.602315006592652 0.0092596756635168 9.691747572815531 31.70873786407767 0.976903841313624 0.2790879029908041 4.4525142732793395 3.04459115485426 1.5883623188049951 0.3063455707490317 2.796440582253547e-07 0.0502821167245636 0.0353550186833354 1.1643127343012024e-05 4.485281643237812e-07 +Respiratory distress 19 53 2.597547249946049 0.0093892201484631 12.805825242718448 52.09466019417476 0.6386570898760532 0.4437575130669694 5.288397728288474 5.051988998968333 1.24726945526474 0.3693239953771813 0.0032816960801128 0.0263546681411107 0.0018041561253073 0.0434311691902502 0.0054654584095901 +Abnormality of glycolipid metabolism 5 7 2.578183435804541 0.0099321257651772 3.83495145631068 7.228155339805825 0.3163887308740252 0.1681411938672545 1.311614193945771 0.5964160722258837 1.870431483654663 0.2292796295173983 8.247959453968683e-07 0.0009934566258862 0.0039135152062846 0.0014684283121974 2.2585304294532336e-06 +Abnormal csf protein level 6 12 2.5779322459249885 0.0099393484496335 4.434466019417476 12.20631067961165 1.1239853500963992 0.2260559983233297 2.11400242863219 2.084072511592451 1.241935948510828 0.248039542652958 0.0008992523581328 0.01497108596825 0.0538434207197609 0.0671599559498881 0.0024204837857025 +Mania 6 16 2.576907329762681 0.0099688672868218 4.29126213592233 13.815533980582524 0.5633198814967983 0.4160552944360035 2.179476502394243 2.2801276272213657 1.0919629859527038 0.3085705503430486 0.0013915714203141 0.1389130578490434 0.2590666885683055 0.0062346640440273 0.0005790030159305 +Abnormality of head blood vessel 10 27 2.5748102496423493 0.0100295092227018 7.512135922330097 24.881067961165048 0.5951213621611695 0.2501622891395578 2.541375726543966 2.628804376839775 1.8399520883426277 0.3043503409762604 0.0001414982700665 0.0029449884503582 0.0025924072114898 8.867302701759687e-05 0.0001244263791846 +Schizophrenia 6 20 2.571761346590208 0.0101182614101451 5.444174757281553 19.50242718446602 0.9817145874838714 0.3473822480141803 2.400301366302062 2.641618717487706 1.084663392230114 0.3211478296747099 0.0012251040975773 0.1795501084992132 0.0588586045542952 0.0004109523281683 0.0032541181407787 +Orthostatic hypotension 5 14 2.57154737657515 0.0101245161619833 3.6262135922330097 14.315533980582524 0.2234754096973065 0.4106322335953559 1.878879089774009 1.367959097892007 1.1506876393484995 0.291561214686976 0.0007898960604004 0.1263420182810564 0.0293903981750984 0.0291459656321865 0.001918269568256 +Abnormality of epiphysis morphology 28 60 2.570404885160462 0.0101579716696911 14.885922330097088 57.24757281553398 0.6699051414631522 0.4959188251133739 5.664066249559964 8.729587504130462 1.029966158611096 0.3689041276003297 0.0051418946521229 1.0 0.8446675734226833 0.0912399214638858 0.0003804434389583 +Abnormality of the umbilical cord 4 7 2.569439224962188 0.0101863257569529 2.3276699029126213 7.713592233009709 0.8125665705120105 0.3888135484058521 1.4654305864343329 1.3565768271996297 0.908107514682906 0.2917208108772662 0.0036066021407721 1.0 0.0255840399150975 0.0032545859437725 0.0074494564855197 +Hepatic failure 16 49 2.567916507465634 0.0102311795448641 12.25242718446602 48.050970873786405 0.7424989852941342 0.3814651163177168 5.527018274076851 5.448329576476532 1.3577793424610205 0.3539023729255708 1.555293117351205e-05 0.389715394886943 0.0029560859975957 0.0031928161135449 7.290650337771797e-06 +Distal amyotrophy 17 59 2.565110652364001 0.0103142906328757 12.737864077669904 57.978155339805824 0.3884383891718266 0.669740564513433 5.443819270821707 6.269591313475342 0.6644819520589975 0.3184210542949114 0.0014164754794747 1.0 0.1449031461986719 0.2359296448343685 0.0001074754896382 +Abnormal lower motor neuron morphology 1 8 2.5620696262067995 0.010405045661407 2.1771844660194173 8.701456310679612 0.8468629004048428 0.2893246976958152 1.3759952567341256 1.207057649999096 1.1584035743641086 0.2695692447215745 0.2726162783327749 1.0 0.0237627189197599 0.1211421538065826 0.3442759855295882 +Abnormal auditory evoked potentials 5 9 2.561012116972765 0.010436771604203 2.837378640776699 8.45388349514563 0.8113355275163785 0.2966376606156203 1.5470802196866602 1.3128600166506037 1.1722229382642326 0.2813987538538041 0.0001073036134456 0.0919337377678228 0.1758008751515455 0.0116756742779249 0.0002747300414667 +Abnormal chorioretinal morphology 14 25 2.5607530841104813 0.0104445558642412 8.45631067961165 26.4004854368932 0.7945769566543296 0.4616483000942599 3.6317817687878136 4.493501214243663 0.9878512993647718 0.3399479614013815 0.03973783993735 1.0 1.0 0.1339560302608873 0.0939632758155837 +Abnormality of visual evoked potentials 6 20 2.557520398330915 0.0105421374899865 5.912621359223301 21.344660194174757 0.5310511795384435 0.4083718861321034 3.290488782756552 2.4160960308239137 1.1796429833196167 0.3304773196682204 0.0076280534495534 0.187449079081247 0.3404254693467198 0.0195417527514502 0.0042906431799932 +Areflexia of lower limbs 14 24 2.553094750369872 0.010677044636592 6.601941747572815 21.186893203883496 0.8014885285213843 0.4297204254543569 3.042066893889402 3.372723692373783 0.977277602505203 0.3249512351298445 0.0004864189955202 1.0 0.3593428278464597 0.3051232152156647 0.0003072272517183 +Hypoparathyroidism 4 14 2.551436288856073 0.0107279936446564 3.3907766990291264 12.677184466019416 0.6232545121271337 0.4810116180385506 1.8513213278290024 1.9719301655035288 0.837395541974523 0.306860352889589 0.0058884014663197 0.1305522111527444 0.031373049189738 0.0048864602536943 0.0119362160344991 +Avascular necrosis 7 20 2.5501075532201853 0.010768969109749 5.070388349514563 21.203883495145632 0.6420454351604097 0.3947374085674277 2.2614105153836106 2.2592172512550373 1.1319127818663337 0.3183649666305153 0.0020814795228306 1.0 0.0021465314893355 0.0118522943314895 0.005918859062877 +Shoulder girdle muscle weakness 4 13 2.54922423525687 0.0107962857478338 4.004854368932039 12.42233009708738 0.8387402263996985 0.3756529644451753 2.0785487207705367 2.2836026739757753 0.9187113892871612 0.2934865228782298 0.1509164607438732 0.1471951297158956 0.2732850813359189 0.1887844423268079 0.0203628052401783 +Pathologic fracture 5 14 2.547529227042777 0.0108488764946914 4.257281553398058 15.072815533980584 0.983166532607372 0.3143076297274698 2.133145812327421 2.2800397788540345 1.0713003315034937 0.2893419439464214 0.0046816994900874 1.0 0.0061250241039257 0.0140312853386763 0.0105883475769395 +Arthritis 14 42 2.547262886577851 0.0108571608659771 10.45631067961165 41.12864077669903 0.9299077951686036 0.3844403642845474 3.7326340917241647 4.351147052994631 1.200139433310656 0.3557501916131977 0.0014908864457078 1.0 0.0005873272870129 0.001172923761026 0.0002143420974933 +Duplication involving bones of the feet 8 20 2.5390100850477477 0.0111166618700213 5.509708737864078 20.026699029126213 0.8286726631699953 0.4291828835649511 2.4019415513574103 3.6259268352065384 0.9263895151182656 0.3280751122544665 0.128578918831075 1.0 0.6320537545500708 0.1033455447275472 0.0622968176328348 +Laryngomalacia 4 14 2.5295607010944177 0.0114205417291872 3.6723300970873782 13.71116504854369 0.5978398108837641 0.454570785907933 2.014971007950381 1.945013939586594 0.9121070716381354 0.3097177989827632 0.1032884224164973 0.2552681350600493 0.1163398228410075 0.0593060830293246 0.1733847659071939 +Airway obstruction 6 17 2.5263818498697197 0.0115244144896107 4.116504854368932 15.12378640776699 0.9459797966632624 0.3434111484412289 1.9597947726604712 2.1010208413382245 1.0021021721123982 0.3085532788047633 0.0304358244693317 0.2443632781182481 0.0181443698350236 0.0509365284789281 0.0215069931551279 +Limb girdle muscle weakness 9 25 2.522868678828026 0.0116401861015176 6.385922330097087 25.211165048543688 0.7046294396116228 0.4863231890570912 2.9011373520939956 3.1532956410624498 0.797735822235521 0.3186211542147555 0.0177565971756722 0.2731012734555347 0.1323300889211223 0.0747731306641884 0.0043720646017646 +Proximal muscle weakness 19 64 2.5198810086882264 0.0117394512198449 14.951456310679612 61.769417475728154 0.5489884587613049 0.5295429242587456 5.9089016947638 6.961944869050214 0.9537081726509974 0.3546417916471885 0.0035227925168373 1.0 0.0574136821119774 0.029796887215469 0.0003696368511182 +Hypotension 6 23 2.5165474725535484 0.0118510933580935 5.793689320388349 25.03640776699029 0.6365055246627263 0.462216755489837 2.8014661523044153 2.878803471228818 0.9034755319984747 0.3145597767048137 0.0108376814481001 0.2516504230112798 0.0198486300115185 0.0564393829037643 0.0254457366029634 +Incoordination 21 71 2.5013918558842008 0.0123706217248336 15.859223300970871 69.11650485436893 0.6868183945924522 0.4621230815272417 5.5138472973140855 6.676725217396416 1.1752874861922693 0.3755559385684158 0.0002002499840787 0.5621314715824117 0.0809872682181705 0.0219741093976294 0.0002123544625109 +Polyneuropathy 7 20 2.499165855501244 0.012448603430569 5.689320388349515 18.633495145631063 1.1475655107151586 0.297256939859202 2.871111980426299 2.8359934163787166 1.1251440285742276 0.3008764483611514 0.0049590977522222 0.0257535715284909 0.0135419734012732 0.0081044088621321 0.0033296386804888 +Abnormality of pulmonary circulation 14 29 2.4806154708219506 0.0131155775509255 8.439320388349515 28.538834951456312 0.8940347945025898 0.342085103264471 3.349932259027002 4.295622811850572 1.233599840087162 0.3264185554851845 0.0120490012497343 0.4043878907472013 0.0036338339198907 0.0446619282438801 0.0145673757087225 +Abnormal placenta morphology 4 8 2.4780593264014024 0.0132099178451874 1.944174757281553 8.475728155339805 0.7648192021909558 0.3426805830523109 1.4036326133106245 0.983797478904342 1.0207702392187767 0.275511162241509 0.0016518039309861 1.0 0.018640880521655 0.0152248647419399 0.0034992238505004 +Splenomegaly 23 94 2.4644777816714303 0.0137213070282775 20.660194174757283 86.74029126213593 0.5649049994066069 0.3835571498509289 6.419862077062851 7.868335701486235 1.546158503499524 0.3590721878602594 2.4696365913320825e-05 0.6755398045514229 0.0067573778891409 0.0004727731856333 5.353801158021762e-05 +Emg chronic denervation signs 7 14 2.4604585876328566 0.0138759584897132 4.550970873786408 13.815533980582524 0.6176194543661773 0.3415909714455588 2.199917039284479 1.6085184210885628 1.2249413291120588 0.2985007469873863 3.4397313711884645e-05 0.1093006244161378 0.0219975904219434 0.0193169154759243 1.0761884384293304e-05 +Hypopigmented skin patches 11 29 2.449047848887526 0.0143234418789472 6.461165048543689 25.37135922330097 0.4666867513080546 0.4923758628930654 3.0339417473242687 3.9530564673509807 1.0171256647501936 0.3356931601315818 0.0898059770896913 0.3654998372428625 0.5982992196000851 0.1916349899499036 0.0384343130412522 +Abnormal vascular physiology 21 51 2.4475410647258826 0.0143834733661147 12.74757281553398 50.021844660194176 0.816183607478715 0.4136638745601454 4.907827009322534 5.622165606934028 1.2216480011219424 0.371091913776798 0.001808382941851 0.5664012088569712 0.024893568816617 0.0566742341902793 0.0017185149822488 +Abnormal muscle fiber morphology 18 69 2.446974680673277 0.0144060958789264 17.78640776699029 68.04126213592232 1.263675841483234 0.3649599499596623 6.500784844979595 6.6307423444197315 1.1691802531751734 0.3853191125649093 0.0024478479320976 0.0419630621111095 0.0044993200044086 0.1936106791400199 0.0002917618827242 +Global brain atrophy 4 19 2.440133461625998 0.0146818366832921 4.944174757281553 20.466019417475728 0.5470181350831151 0.5081828354508747 2.583421763532785 2.0184370286085005 0.920761985531802 0.3339660659374047 0.0356515059560401 0.0196403757049561 0.0693457394610891 0.0940672040532474 0.0655768501043339 +Decreased activity of mitochondrial complex iv 2 15 2.4242768788080364 0.0153389057658588 3.878640776699029 15.9247572815534 0.8034271187166634 0.3445303465767608 2.844656052218728 1.5238137800378977 1.1422119451186783 0.2970372577525856 0.1047870051117089 0.1263420182810564 0.0023694947377154 0.0291459656321865 0.1526461610854137 +Psychomotor deterioration 3 9 2.4201506159036987 0.0155140797704327 3.2645631067961167 8.910194174757281 0.9753014938956188 0.1960965459818884 1.3866235282600423 0.7031088807706056 1.4929387846379636 0.2609606457365817 0.0001094986389743 0.0017062060788896 0.0066572828402184 0.0001991597833083 0.0002457979454447 +Abnormality of peripheral nerves 15 45 2.4108004729041443 0.0159175537994731 10.25 46.179611650485434 0.6405954271790926 0.5475676474607668 4.435418457508139 5.762430366840002 0.784998085911033 0.3389861349319225 8.999276943728704e-05 0.3985608327989486 0.0801526286479979 0.1098174049188518 4.265050978373963e-05 +Emg neuropathic changes 12 26 2.4089851713949773 0.0159969479308976 6.915048543689321 24.58252427184466 0.5887299592537784 0.4208819793990807 3.046574831105746 2.544837804909062 1.1306803597402475 0.3318248802653038 1.3549839760795887e-06 0.1952735388158895 0.0693457394610891 0.0227330174276438 9.950941556486035e-07 +Abnormal peripheral myelination 11 31 2.404636940027667 0.0161885397474046 7.635922330097087 32.13592233009709 0.6742900044491671 0.4743014543601314 3.568806451618386 4.873244854452022 0.9969709958674222 0.3457305187498817 0.0001460553946487 0.0614819278885333 0.0469329673676288 0.0521122233315559 0.0001879207605363 +Personality changes 6 17 2.403833863754248 0.0162241446925566 4.235436893203883 16.20873786407767 0.716641708966708 0.4361664780008399 2.2513009299259603 2.2727002372019856 0.9467269936740988 0.3182188186141179 0.0040997845467264 0.1675604235637086 0.005693097574516 0.0630731351339203 0.0020709532532559 +Abnormal epiphyseal ossification 11 16 2.400171594920302 0.0163873878562972 6.451456310679611 16.274271844660195 1.1227269321938518 0.3276999393402902 3.140724178369711 2.4155680760400804 1.043634905787503 0.3148370578580727 0.0018793486184411 1.0 1.0 0.0039562767661884 3.704127201812019e-05 +Abnormal cardiac ventricular function 7 19 2.399881213515378 0.0164003929426894 5.262135922330097 18.648058252427184 0.6561483334031016 0.4063512942618581 2.801563935800768 3.037775296806565 1.0608023601658336 0.302693194134391 0.0353434636779219 0.3075216202298709 0.0365585180593606 0.2776494479137136 0.0304896229948475 +Gait ataxia 20 72 2.3992086208879675 0.0164305506544459 14.351941747572816 68.35194174757281 0.6787136514518399 0.4783255809544575 5.256980668043156 6.678826209042067 1.046898326537344 0.3693668840587258 0.0004130924248184 0.1878650647832112 0.074375194998397 0.1044344220246968 0.0010684007019133 +Transposition of the great arteries 2 5 2.390766776335344 0.0168132293738509 1.203883495145631 5.665048543689321 0.7562120366134815 0.4185380653537092 1.1667665326732786 1.0969692349824032 0.827947918729971 0.2809375696957198 0.1811751146833997 1.0 0.0466281418945222 0.0552623668853733 0.2535314416198171 +Fluctuations in consciousness 4 7 2.387852821895192 0.0169471270646799 2.871359223300971 7.104368932038835 1.0899440920546752 0.2545542015295898 1.680977263462837 1.481694234866534 1.1451509420956862 0.2733842157028129 0.0008071226260475 0.0875404472016038 0.014058804472369 0.0101015401572799 0.0017429018144962 +Urinary urgency 4 9 2.384437525413877 0.0171052521057577 2.6432038834951457 8.830097087378642 0.2710626498471533 0.5191928231359926 1.75885483131918 1.823595879662381 0.8867610986250853 0.2896393000629766 0.0078803131844108 1.0 0.2590666885683055 0.1713585638073601 0.0157766780310383 +Hip pain 1 5 2.382841803832808 0.0171795751781376 1.424757281553398 5.0 0.859024349165147 0.3344821452752615 1.281560293450117 0.0 0.9235596175512634 0.2706747767807553 0.0305702565140493 1.0 0.0018609890552042 0.0112385866308786 0.0419919493306108 +Recurrent aspiration pneumonia 2 6 2.378863155657806 0.017366121549357 2.0606796116504853 6.25 0.3948833569251968 0.2988616259147967 1.2222482563963537 0.6632700690261994 1.354266830500057 0.2888538147928982 0.0255771152801701 1.0 0.0100519320580488 0.0557098434243155 0.0397387250697101 +Morphological abnormality of the pyramidal tract 7 20 2.3752793867006097 0.0175356714917533 5.978155339805825 21.21359223300971 0.941567362517309 0.4190895040605777 2.5839325217273803 2.130000617333851 0.9433759961177594 0.3444076850385922 0.0108376814481001 1.0 1.0 0.1760149897618766 0.0080767934135705 +Nephropathy 5 23 2.3735491831068627 0.0176180464917257 4.953883495145631 20.679611650485437 0.6460031144846833 0.4125859609731191 2.359716427347698 2.5216098734814283 1.0719980152629416 0.3150102108345451 0.0491033002504774 0.2695684389372801 0.1290920553826253 0.2067196289529824 0.0946135485635064 +Abnormality of the phalanges of the toes 5 15 2.373403790386477 0.0176249840635536 4.310679611650485 16.216019417475728 0.657145942013654 0.4547589157091309 2.217665729026992 3.9902107980926513 0.8561226490575587 0.3038881989407645 0.4966302662187861 1.0 0.2107495506364678 0.3637482043753135 0.6334781488560652 +Central scotoma 7 9 2.3700884351131686 0.0177838309916673 3.657766990291262 9.152912621359222 1.2790732929494344 0.2261272578521709 2.0233738200365714 2.077016218281829 1.2675536526802949 0.279373459017325 0.0042802590673059 0.0073558029266518 0.0021303683071518 0.0037492480554313 0.0015706126808535 +Orthostatic hypotension due to autonomic dysfunction 4 9 2.366222620107441 0.0179706348204633 2.8689320388349513 9.026699029126211 0.6690910568198125 0.3153802844238013 1.4405048418053912 0.8105887688186777 1.185865447592776 0.2910194211316744 0.0001646358659008 0.0652597674910206 0.0077184558590264 0.0041470760753771 0.0003671727016274 +Abnormal social behavior 19 67 2.3643446555897527 0.0180620004848486 16.796116504854368 65.80339805825243 0.6678301735588785 0.4940185804874849 5.994105880514205 6.839540104535511 1.1033956384068455 0.3774724921329495 0.0010960963278562 0.007790742895198 0.0049209792286377 0.0006090439147331 0.0003697595096921 +Abnormal tongue morphology 24 69 2.3561808179937995 0.0184639276448714 16.939320388349515 69.1116504854369 0.4277424777250148 0.5766387697572775 5.679438944349523 6.766002978496539 0.9505300446189564 0.3567930620053219 0.057914337066509 1.0 0.6160018336713062 0.4175691232726971 0.0039614891810969 +Frequent falls 12 39 2.3514356046081484 0.0187011263101406 8.643203883495145 38.75485436893204 0.6268988624161936 0.4831027569691007 4.0086529499315136 3.828305504664436 1.0909180744790496 0.3651237988976172 0.0007230291383298 0.3403437958043751 0.0497306095082375 0.0566012047710065 0.0002392045981973 +Central apnea 3 7 2.3490247190758957 0.0188226571717853 2.6140776699029127 7.645631067961165 0.7865100475706397 0.3005269589284746 1.5309416715650457 0.8593604190958345 1.1613991531101726 0.2793709321885783 0.0153022136017921 0.1093006244161378 0.2070995190727305 0.0193169154759243 0.0269295467729808 +Abnormality of lysosomal metabolism 3 5 2.3453690470368245 0.0190082545655567 2.0509708737864076 4.776699029126213 0.6001877831871685 0.2139165882109918 1.054267347463803 0.832379194243084 1.5763659100060583 0.2506311014666729 0.0002949968218243 0.0424464003246627 0.0031504918831051 3.788095303003865e-05 0.0005688349419973 +Myoclonic seizure 15 52 2.3352066174434616 0.0195326296136375 11.686893203883496 52.98543689320388 0.3944988422537482 0.4078474078990697 4.250245345088794 5.776566450302065 1.383306240067707 0.3629970156021384 0.0071736473140743 0.1570363283812061 0.0529971691837449 0.0029371177900416 0.0051204224124838 +Abnormal larynx morphology 7 27 2.334358446568604 0.019576960700401 6.839805825242719 27.718446601941743 0.5738284857128313 0.4761706892213789 2.8749956456134265 3.1319446353032743 0.987106786856402 0.3377886307734372 0.0654980357877151 0.0904452781629929 0.0183313093591291 0.013435076878633 0.0686472570530836 +Hydrocephalus 29 75 2.331590205567333 0.0197222595775532 17.5 74.83009708737865 0.4864280032519437 0.6085787069163106 5.8879092832817435 9.478912056611868 0.8088784016382273 0.3500416531762792 0.116083457947856 1.0 0.7590193117736533 0.2416525582329887 0.0571806106583182 +Neuronal loss in central nervous system 4 12 2.327995116397877 0.0199123629869188 4.087378640776699 12.526699029126211 0.982175765643533 0.2959736314179056 1.731247914675439 1.993135251988059 1.1236470294677874 0.2967990988512021 0.0068337419321114 0.134742527043449 0.0028960612595367 0.0055331858379351 0.0137665493817408 +Abnormal heart valve morphology 22 75 2.326098328088807 0.0200133057300804 17.83252427184466 77.13106796116504 0.4699099631595928 0.6096529829544438 6.02733340682127 8.717091003223958 0.8450929313560487 0.3556463006581863 0.011575283153684 0.7229556725912962 0.1089652119169875 0.0113256212906844 0.0171535813755606 +Peripheral axonal degeneration 20 71 2.325215627510498 0.0200604331336442 16.691747572815533 71.19902912621359 0.6211832637355972 0.5650732986012978 6.425044282599762 8.4263916789636 0.8780908495791551 0.3675751486040735 0.0001267969639828 0.1861284851480595 0.2090916069235549 0.0450832016081914 4.311408572261659e-05 +Cardiovascular calcification 3 9 2.3216758921914065 0.0202503939989486 2.308252427184466 8.859223300970873 0.7108888353244642 0.3297311623074345 1.5295249133480504 1.112413355910707 1.118415370096058 0.2755617850539273 0.0201952000669413 1.0 0.0019068669696529 0.0239571113561098 0.0351238878380088 +Hand polydactyly 13 35 2.317233816719088 0.0204909983367163 9.114077669902912 32.17718446601942 0.810453590544338 0.4452800586149166 3.6615419153480793 5.309376559579211 0.948384387998628 0.3474317696921568 0.076199146808576 0.5075688851536699 0.4109588963272705 0.0250151443810998 0.0515605502055438 +Abnormality of the ribs 31 67 2.315573636095704 0.0205815597048264 15.46359223300971 63.26456310679612 0.6596881680500318 0.4822792711086646 5.162987649103379 7.327989071924885 1.0464354559452582 0.3722680363619953 0.0202272036284153 0.6294205244747506 0.1330886303833328 0.0588745965413039 0.0021562678564484 +Abnormal lung lobation 5 14 2.315124969752142 0.0206060938784649 3.266990291262136 13.402912621359222 0.8057824047211188 0.4237226990881645 1.8647412350490211 1.7258152040640289 0.8098324555644494 0.3032019531807652 0.0442625920896186 0.1471951297158956 0.2732850813359189 0.0444854600227105 0.0203628052401783 +Abnormal elasticity of skin 19 61 2.308887455531988 0.0209498272753489 12.949029126213592 61.342233009708735 0.3908434863184051 0.6206140883004606 4.691432392388869 5.29075607716294 0.8206735368420446 0.3519232728015974 0.0007328735656006 0.5356345621372292 0.0656047650092995 0.0049129960596837 7.695224435001802e-05 +Juvenile onset 15 44 2.3073934313321742 0.0210328970954396 10.220873786407768 41.28155339805825 0.3416766536043948 0.3540580800469471 3.658644665705508 2.990007551791468 1.4952530140825149 0.3282418399186692 0.0007532555551053 1.0 0.0714976342213511 0.0940079969551786 0.0003176274883727 +Abnormal corneal epithelium morphology 5 17 2.305005699981955 0.0211662541861901 4.177184466019417 16.62621359223301 0.8116695621933796 0.4446326391054055 1.7953996864022932 1.7490891479802395 0.7696685494080681 0.3046964378924103 0.0327593534605507 1.0 0.018985818871393 0.053649406266927 0.0654262733188917 +Middle age onset 2 11 2.304943319913097 0.0211697480237424 2.3567961165048543 10.058252427184469 0.2336229973862058 0.5304493567741497 1.7477801252441654 0.9661779642543156 0.8480559321463624 0.276826590957438 0.0656286176794259 0.1049896535105009 0.0202898922491691 0.0172025832638257 0.0981468657129251 +Nasogastric tube feeding in infancy 2 9 2.293764515650395 0.0218040286834269 3.0097087378640777 8.495145631067961 1.0003947416243104 0.2675726652756056 1.510449978803449 1.1668877069106371 1.1016283190777107 0.2724768109071007 0.1135131683065525 0.0084566179175882 0.031373049189738 0.0319451393300601 0.1645088237572309 +Action tremor 19 53 2.280583268186356 0.0225731183189068 13.143203883495143 54.47572815533981 1.1235280535029035 0.3645421720231636 5.4627047451961745 5.814853194507433 1.1817578847970691 0.3688885139588422 0.0026911564690209 0.1306031110532128 0.0084980050977086 0.0971253180165182 0.0044670933536771 +Entropion 1 9 2.2789727776407536 0.0226686835710201 2.0266990291262137 8.905339805825243 0.7183648201929476 0.4594851522435767 1.7971838209030155 0.9364623739029158 0.7157069084045841 0.2801493152786577 0.1961489377181922 1.0 0.0155240337321844 0.0828772873031817 0.2531867173469597 +Degeneration of the lateral corticospinal tracts 2 7 2.2742194911504945 0.0229527929087387 1.91747572815534 6.543689320388349 0.7561294413609913 0.4260862878985212 1.2219614333343374 1.301803819717693 0.8237278722604997 0.3013218286302411 0.0404477004850345 1.0 1.0 0.0757571260003459 0.0618109910728358 +Progressive spasticity 6 15 2.272332568295378 0.0230664311379298 4.310679611650485 15.677184466019416 0.3665295652655519 0.4383580490709103 2.2099911092980777 1.5344471301085942 1.08331515350054 0.3117516214812866 0.0020407072579174 0.0053672672920639 0.0202898922491691 0.0172025832638257 7.568702219565374e-05 +Sensory neuropathy 10 32 2.27184897795822 0.0230956334703862 9.17233009708738 33.75485436893204 0.684837850359792 0.4572087500958895 3.983815730493952 4.346698415431409 1.0448123352909229 0.3439679266340525 0.0112497451158167 0.3041527321586795 0.5166489093314391 0.1071524979756758 0.0009220641745238 +Thoracic scoliosis 2 13 2.2706373546621204 0.023168940202501 2.895631067961165 11.815533980582524 0.7054864621280054 0.4260251550564725 1.907135385454388 1.092761468704903 0.8938736368000172 0.2999782404089314 0.0963402202365331 0.1221118561195742 0.0021303683071518 0.0264830942684438 0.1410707299584872 +Disproportionate short stature 14 27 2.2683336321032965 0.0233088795309173 8.58252427184466 24.70145631067961 1.4449047806081987 0.2464238748623315 3.3320283680556178 3.793287097673045 1.0910515137563812 0.2952991105687103 0.0715644387615555 0.3498897642406863 0.5782406044087871 0.0637395822669413 0.0108141130310289 +Abnormality of the gallbladder 11 42 2.264272105995806 0.0235573840954304 9.223300970873789 38.0752427184466 0.5027702533780772 0.5379447420549962 3.587145439560844 3.3423828325522775 0.8984096284409542 0.3445277538035425 0.0001152950369921 0.3274019772455256 0.0442161560616649 2.5917903680851456e-05 0.000146373457931 +Cerebral dysmyelination 2 8 2.250647664632893 0.0244078619545902 1.6286407766990292 7.055825242718447 0.5887869749232204 0.3891898742700928 1.2754040277752834 0.7202278823189237 0.9907764921844316 0.2830027899418403 0.0255771152801701 0.0742352733278267 0.1432798584585485 0.0061570039439817 0.0397387250697101 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0.6623037513988556 0.3539209052149137 1.4095799340712598 1.43559702755526 1.0696389563271094 0.2888576403054313 0.2112908002181378 0.0963063052639835 0.1837383274168749 0.0901924811619011 0.2715157705871365 +Hyperconvex nail 5 8 2.2307966090913123 0.0256946046706867 2.405339805825242 7.939320388349515 0.7351828941114927 0.3065172604341125 1.3467943353086171 0.7527989998960608 1.0793151443208264 0.2411455315204656 0.001050672309299 1.0 0.1094892401774078 0.032628233248221 9.139729707100432e-06 +Mucosal telangiectasiae 6 11 2.229661440874672 0.0257699275730047 3.2354368932038833 9.689320388349516 0.8501086222195428 0.291727970426265 1.410916714116348 1.5996305775803197 1.2598794700933909 0.2907637890882055 0.0259503462691174 1.0 1.0 0.1457934990596532 0.010278445998416 +Abnormal autonomic nervous system physiology 9 31 2.2279357077835997 0.0258848026001226 8.24757281553398 32.320388349514566 0.4638475540870246 0.4509985093876737 3.0051523606495087 3.6502788621576223 1.089960321271389 0.3249871136051702 0.0010007805331772 0.3075216202298709 0.1656331484196294 0.0363101363561639 0.003548440361811 +Ectrodactyly 7 17 2.2276367454688897 0.0259047482377479 4.12378640776699 15.87864077669903 0.8198140763126681 0.3757221931635416 2.0209382693093176 2.284355849612238 1.0264971379648948 0.291688305539228 0.003138705966493 1.0 0.0775813155228076 0.0280832529132891 0.0019780921583714 +Decreased activity of mitochondrial complex i 6 32 2.227534800744866 0.025911552642811 9.281553398058252 33.63834951456311 0.9162605947168436 0.3572379048008119 4.7041965890170365 4.116953486956332 1.2998989973013628 0.34388058367185 0.0044439773047646 0.0248381956323572 0.0001225386178253 0.0002044748778434 0.0029392451780606 +Prominent superficial blood vessels 4 12 2.226643256361706 0.0259711255699852 2.966019417475728 11.716019417475728 0.6491352145956659 0.4442625592038562 1.799085711599426 1.1210413326572193 0.9002840813907198 0.3052045190809893 0.0201952000669413 1.0 0.0255840399150975 0.0239571113561098 0.0074494564855197 +Abnormal gallbladder morphology 8 34 2.223943719493129 0.026152231082005 7.478155339805825 31.075242718446603 0.4272058322069254 0.5481313499841369 3.2037612142007585 2.976716880674025 0.8468189606834012 0.3256570196959197 0.0018861306961519 0.2835996474450377 0.1421535555390922 0.0002404412649958 0.0058898561186024 +Mixed demyelinating and axonal polyneuropathy 3 5 2.221549873665257 0.0263137406542968 1.4757281553398058 3.861650485436894 1.0618051586825854 0.3019785112671438 0.9638581472614256 1.1670164407518866 1.082154445030509 0.304718894009896 0.0004758293614935 0.0470522829573702 0.0039135152062846 0.0229613270793894 0.0009118158302113 +Abnormality of skull ossification 5 13 2.2170775245766934 0.0266177943583802 4.366504854368932 12.970873786407768 1.1881205011944458 0.2637442069575459 1.99249670608582 1.4511884027191762 0.8848235988748787 0.2626440236811827 0.0022919137726945 1.0 0.0420348553288257 0.0086864012748381 0.0053527619374205 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7.354368932038835 0.6505903571445167 0.3551914870642563 1.248646642239502 1.3902068505046723 1.081635717396615 0.2816956203568134 0.0008071226260475 0.0875404472016038 0.014058804472369 0.0101015401572799 0.0017429018144962 +Premature rupture of membranes 2 5 2.2108054133981847 0.0270493148145389 1.5631067961165048 5.800970873786408 0.9509293139272904 0.2937126614282376 1.1899245542912666 0.3992700002908385 1.068670600999266 0.275907562675117 0.0047446129612751 1.0 0.0031504918831051 0.0010464818333657 0.0076703518288617 +Aplasia hypoplasia of the tongue 3 5 2.210397832403989 0.0270775641117095 1.4757281553398058 4.553398058252427 0.3110758073975282 0.4811965236737809 1.132868686159637 0.9108638313269062 0.9677247561299708 0.2957977310516449 0.6627990523922089 1.0 1.0 0.4704807306772423 0.0351238878380088 +Abnormality of the distal phalanges of the toes 3 5 2.208860085219594 0.027184374236044 2.094660194174758 5.058252427184466 1.0467054837889296 0.2409661092181722 1.19191069217632 0.9786581135773657 1.170071232541671 0.254087308422285 0.0026277975298375 1.0 0.0088504827764808 0.0050923434600555 0.0048822579474643 +Scotoma 7 12 2.208208676558949 0.0272297298449049 4.189320388349515 12.196601941747574 1.1271039056750725 0.2779036999445621 2.1128553643245884 2.0698220238662226 1.1901076059375446 0.2884356618441315 0.0226355949376145 0.0157111699130222 0.0065760397653667 0.0153023562212604 0.0119603409362114 +Decreased number of peripheral myelinated nerve fibers 7 16 2.206844551112234 0.0273249213662349 4.269417475728155 15.449029126213592 0.5470641849851599 0.5309325631616826 2.362271543479177 2.3749959691588103 0.7924715482597077 0.3124068087690249 0.0004526864338107 1.0 0.2872333566147377 0.2064377407436189 0.0002147363626889 +Abnormal visual fixation 2 7 2.2060589038281955 0.0273798756743099 2.1237864077669903 6.516990291262136 0.3282606812074232 0.2644845064785266 1.2333226229346623 1.2136771814929264 1.4687997702265556 0.2650474123539905 0.0350962772824537 1.0 0.0126574737404708 0.0086586519898169 0.0539281835546241 +Abnormality of retinal pigmentation 18 71 2.2038315168551184 0.0275361952027735 17.82281553398058 72.90776699029126 0.3206615768516952 0.5948763422977358 6.463126466599106 8.392162193130181 0.987895502495544 0.3528647433942398 0.0276498831295231 0.6755398045514229 0.3836456925968915 0.1069148524062087 0.0171605499827579 +Pericardial effusion 2 6 2.1973572511338952 0.0279949418152309 1.9466019417475728 5.980582524271845 0.6333430474464145 0.2773316461993735 1.2136213588737947 1.4646685732948297 1.3006352977804805 0.2635985168358294 0.0587858303044749 1.0 0.0011613234829685 0.0152248647419399 0.088385561156941 +Hypertrophic cardiomyopathy 35 106 2.1968708383190125 0.0280296720733541 26.796116504854368 107.3495145631068 0.4274787301303976 0.4988726739093555 10.944572821213892 9.196568310864103 1.312724112644841 0.3809066370755179 5.3605021645772664e-08 0.0971647579418701 0.0064521859740737 0.0004313054915476 4.556325328781316e-09 +Abnormal thoracic spine morphology 4 27 2.196550822079188 0.0280525417340538 6.558252427184466 27.104368932038835 0.8238927765093872 0.4398474942511601 2.7009535990178555 2.5649391710658156 0.8855000478727516 0.3360788168488923 0.1088041646054592 0.2588687133858448 0.0003105660221664 0.0166327696461577 0.0792626216408109 +Muscle spasm 16 59 2.194492266835169 0.0282000392852661 12.46116504854369 57.41990291262136 0.5782385518256496 0.5270109112328661 4.685854213547734 5.0957713280196595 0.8793305042203639 0.3427211662973412 8.918302063299837e-06 1.0 0.3281099840481742 0.0281363706052967 2.2512981760595702e-05 +Brittle hair 3 15 2.1931714865943324 0.0282950260634926 3.9223300970873782 15.133495145631068 0.7155570866703008 0.488149294465297 2.2336322475397568 1.0493384034370854 0.7650144087086427 0.320703410400334 0.0229630158929653 1.0 0.2297987482657219 0.1374615323876937 0.0397044670530444 +Generalized clonic seizure 1 5 2.1931284621193496 0.0282981248927525 1.5825242718446602 5.436893203883495 0.6674704003168754 0.3317689581735804 1.1681391046692513 1.2141552092256307 1.1398423523204038 0.280516760635508 0.1234662274193449 0.0697581245313758 0.1349531130589082 0.0495157384890535 0.1630814235328921 +Impaired vibration sensation in the lower limbs 5 13 2.190676331270972 0.028475223061013 3.5436893203883497 13.5752427184466 0.6952737045250533 0.4242336391370475 2.2993316843683766 2.2069327415111175 1.0005780794846004 0.3215228956981494 0.02047141811426 1.0 1.0 0.2421879711614701 0.0105883475769395 +Loss of speech 8 19 2.1890472858534897 0.0285934033327832 5.453883495145631 19.1626213592233 0.4726173662677797 0.3013153148889984 2.223071754411353 1.8941045281154043 1.521023928928509 0.3006842241053739 0.0014193499494706 0.0010496761988569 0.0006788789579845 0.0032221742646108 0.000798592209508 +Raynaud phenomenon 2 6 2.188600923130956 0.0286258586763163 1.5145631067961165 6.242718446601942 0.9919476180863708 0.3155318164932874 1.0668352405519568 0.7236104114257896 0.8937818768405142 0.2739634297108673 0.021417379304658 1.0 0.0088504827764808 0.0050923434600555 0.0334620993119388 +Macrovesicular hepatic steatosis 4 8 2.18076508427795 0.0292007963262976 2.466019417475728 6.87621359223301 0.939079379807938 0.3067324443022926 1.4701927354039712 1.258646689249585 1.014263353538022 0.2700508944960845 0.0004758293614935 1.0 1.0 0.2167775624926856 0.0009118158302113 +Exercise intolerance 8 33 2.1762156425195496 0.0295391397952868 7.589805825242719 32.94660194174757 0.6935647402019111 0.4794430320014746 3.6422804337959303 3.649320073231373 0.9787082553108852 0.3464451860868903 0.0030746286236722 0.0053226708337122 0.034172513126223 0.0087565646797269 0.0092851689807755 +Limb ataxia 11 25 2.172405957039173 0.0298250560888699 6.597087378640777 24.114077669902912 0.989869123864314 0.3154216467413447 2.5039369509835696 2.8496458430585005 1.1323309577692284 0.292147514752726 0.0001222984688709 1.0 0.1100932826860655 0.053649406266927 0.0004875982127202 +Postaxial foot polydactyly 4 7 2.170406579918369 0.0299760587781079 2.9101941747572817 8.179611650485437 1.1164564935210708 0.2854713626620553 1.5514456024758956 2.174827712105029 0.9565986562813577 0.2724819159224514 0.3017222935373305 1.0 1.0 0.3140672800286707 0.0762091064419948 +Abnormality of the 5th toe 4 7 2.170406579918369 0.0299760587781079 2.9223300970873787 8.259708737864077 1.1073405288994291 0.2882520454965396 1.560677724258624 2.165041741031587 0.9522253135241228 0.2721172964763348 0.4252664838612698 1.0 1.0 0.410005165463368 0.1495389057689769 +Distal muscle weakness 16 66 2.1689304161775604 0.0300879671269937 13.99514563106796 64.27912621359224 0.378143548680081 0.6371085023737708 5.834278994576672 7.014703781301811 0.8046554605614199 0.3362876084172668 0.0099074037605568 1.0 0.434229758340125 0.3098920583685768 0.0011890683804827 +Abnormal circulating copper concentration 3 8 2.1681413040161868 0.0301479370601325 1.8422330097087376 5.575242718446602 0.7192357902216235 0.3771156375814327 1.260629702441343 1.0104640332277932 0.9717173289058264 0.2836036003591781 0.0001693477472854 1.0 0.0743799864466655 0.0147480216610697 0.0003286021100258 +Convex nasal ridge 5 21 2.166277142354427 0.0302900153146561 4.883495145631068 21.233009708737864 0.2011679113331868 0.6568794085922401 2.5771624754240308 2.9582987878766307 0.6917317571216339 0.2902292306691292 0.0261187713697616 1.0 0.0165254238564816 0.1524764865133537 0.0531216479129258 +Abnormality of the tarsal bones 11 30 2.161243216703254 0.0306765566784781 7.135922330097087 26.50242718446602 0.598228998535255 0.5095033527659901 3.3211547403728976 3.593750499473341 0.86584218888204 0.3274398125512684 0.0016429517647272 0.3241278561278478 0.0428883183388871 0.0033316897742691 0.0004978062317691 +Infantile axial hypotonia 3 10 2.1605771428400056 0.0307280186379055 3.0970873786407767 9.91747572815534 0.2141703344813526 0.3664899290512883 1.6385203075306134 1.5973234399272347 1.21609252960959 0.2741067096589152 0.032595105977084 0.0090330503435184 0.0334071197556988 0.0055331858379351 0.0553856285019619 +Diarrhea 19 74 2.157907283336145 0.0309350411201885 15.235436893203884 71.36893203883496 -0.0937123546508902 0.4891141680274506 5.321271341758422 8.34189367719314 1.2527606286184891 0.3588826008598239 0.0056194503630012 0.6401941397824427 0.3283518743015015 0.068051675804051 0.0136567371586889 +3 methylglutaconic aciduria 3 10 2.157738675755184 0.0309481551502597 4.072815533980583 10.594660194174756 0.3579974396117663 0.4371570089867337 2.2174372584356252 1.5620718849823747 1.1566220028171512 0.333066618505644 0.0053451996563463 1.0 0.1596960736798767 0.0086586519898169 0.0097510399506001 +Abnormal exteroceptive sensation 15 52 2.1566554745505617 0.0310325186828317 10.759708737864075 52.02427184466019 0.4941713240335635 0.5557419524937993 3.9194595318694754 5.696566262954939 0.9102536370390476 0.3437672640084617 0.0044972448613632 0.4904368630106878 0.387240354948832 0.2449106044764256 0.0011276322830495 +Oromandibular dystonia 2 5 2.155173902720371 0.0311482283008026 1.730582524271845 4.956310679611651 1.1882502597012077 0.2382412593757527 1.131086190944388 1.1979083634266432 0.9893427275402558 0.2482274576089271 0.0176594629498872 1.0 0.1265462710440741 0.0435926191526008 0.0277461310389573 +Hyperextensibility of the finger joints 4 5 2.1545810351239565 0.0311946344206688 1.395631067961165 3.949029126213592 -0.1445123293545377 0.4650034929802019 0.9859598545391882 0.8921578668295418 1.0975580663497662 0.3095922198730165 0.4657083464778854 1.0 1.0 0.3069124011154697 0.0005289198821125 +Abnormality of hand joint mobility 4 5 2.1545810351239565 0.0311946344206688 1.424757281553398 4.138349514563107 -0.1327716039133116 0.4653843150335018 1.0032320048976022 1.0556299339499715 1.0940189843013757 0.3096557805371643 0.5843047590796981 1.0 1.0 0.4015375820029667 0.0028145739091465 +Inappropriate behavior 5 17 2.147489132776163 0.0317543614289321 4.111650485436893 16.885922330097088 0.1384539200488892 0.5568708768969491 2.346689507546719 2.02390948073287 0.8632293435648196 0.2961880037432384 0.0067920673311003 0.0172375696548913 0.0075361578498098 0.0032221742646108 0.0150707717640174 +Abnormality of the tongue 28 87 2.140754349896495 0.0322938530618475 22.424757281553397 89.52912621359224 0.5421010507218363 0.5607339999720974 6.938472222740965 9.436122816051313 0.9593463898963266 0.3606735981467843 0.0293557042998151 1.0 0.4855137156242374 0.2084272349212674 0.0015232389405862 +Shuffling gait 2 11 2.139944402655882 0.0323592601169924 2.395631067961165 11.230582524271844 0.6109447518071078 0.4679989342941459 1.905862274541426 1.6198815282358896 0.8086665925844128 0.2924773789974313 0.1225040641215365 1.0 0.0028960612595367 0.0348798008289802 0.1766336232289773 +Sclerocornea 6 9 2.1384885309729715 0.0324771139923021 3.1237864077669903 9.691747572815531 0.6327344825269637 0.4627390478210677 1.6813417067808916 1.93451779053892 0.8687114450254205 0.3021244352075571 0.0026724435668977 1.0 0.2872333566147377 0.051542815486873 0.0012514150662819 +Lower limb amyotrophy 7 18 2.1383769611996537 0.0324861607959685 4.599514563106796 17.79854368932039 0.4204622424068837 0.5444570422467591 2.3436134570776987 2.274958191343983 0.848761300245189 0.3106630644747082 0.0095183457400119 1.0 0.3530974878629287 0.2961580697833918 0.0012835617051806 +Prenatal movement abnormality 21 61 2.1375080010009104 0.0325566956560221 12.398058252427184 58.41504854368932 0.2301808818459553 0.6896691980273608 4.94501770604631 6.063584343829225 0.6421785295244297 0.2980837946342114 0.0127833228900773 1.0 0.0114556487875666 0.0070795889124285 0.0034579667372552 +Axonal degeneration regeneration 3 5 2.1371811975851003 0.0325832567233781 1.8131067961165048 4.237864077669903 0.1583088803793944 0.5553111085380648 1.2173993681632571 0.9737941514952148 0.89750689277426 0.3080736036806136 0.0021018851435908 1.0 0.0653907127050202 0.0112385866308786 0.0001708540892308 +Ankle clonus 6 16 2.1289214574497883 0.033260759167895 3.575242718446602 13.298543689320388 0.6380030192173395 0.4332907678689981 2.0352878876827107 2.085711402355677 0.9658483329689804 0.311402478823635 0.0013915714203141 0.1389130578490434 0.2590666885683055 0.0379489226270714 0.0005790030159305 +Ichthyosis 9 36 2.1261279958170216 0.0334926034380731 8.480582524271844 34.25970873786408 0.3409120777846118 0.5778048298426558 3.460191314437705 3.8733628439628025 0.8862490869838126 0.3320426472696649 0.0028166421354473 0.343540942585206 0.0014681571022129 0.0011583241908442 0.0092691592276467 +Abnormal choroid morphology 15 27 2.1175385890927547 0.0342141638455129 8.601941747572816 27.3495145631068 0.7703870977149745 0.4720542672282273 3.667860427157979 4.9083023341259215 0.9853391072008848 0.3404582870775928 0.0759621810042363 1.0 1.0 0.1926043528586322 0.1640104998874151 +Abnormal enchondral ossification 13 29 2.115334927739537 0.0344014115910822 8.825242718446601 28.097087378640776 0.9354465670440578 0.4238671948965085 3.7994051258084856 4.343870948544361 0.9586864854575652 0.3408490652683477 0.0025846109885662 1.0 0.5657328567415809 0.0175312180624397 0.0002392045981973 +Slurred speech 4 9 2.11395351644468 0.0345192376857501 2.45873786407767 8.864077669902912 0.5323927403653204 0.4147809462031548 1.4075891250208603 1.616351781434359 0.9973486618272436 0.2852319096618858 0.0050390336340173 1.0 1.0 0.4957890007184933 0.010278445998416 +Abnormal activity of mitochondrial respiratory chain 18 51 2.108053711137033 0.0350263437401863 14.847087378640778 52.86407766990291 0.7821137838412346 0.382257667326437 7.203923975365814 5.31995427327111 1.5049815702887546 0.3635380021892623 0.0012759992349272 0.0097083087369112 2.746180882061552e-05 7.074199918744216e-05 0.000129249341769 +Coxa valga 10 23 2.107897016858707 0.0350398983299566 5.245145631067961 19.95145631067961 0.3761170106319844 0.4485543113651226 2.6522752145550523 3.395824508532713 1.0354006500412785 0.2987185055269495 0.0460874080481704 1.0 0.1258733376055511 0.2004801313125411 0.0347439304052366 +Echolalia 3 8 2.107815606986126 0.0350469423291976 2.9174757281553396 9.798543689320388 0.5058827478481593 0.4925214398455364 1.939118365602947 1.8645121737734769 0.8858392104742214 0.309610151743164 0.048607244419577 0.151306852499084 0.2802926639431586 0.1975866021584996 0.0807266025333323 +Spastic gait 9 24 2.102441265779512 0.0355146395814103 6.211165048543689 23.233009708737864 0.1904978612336374 0.625701248220307 3.154065276571727 3.5064541974394436 0.792545244400234 0.3078027861065657 0.0005993288235478 1.0 1.0 0.053649406266927 0.0004875982127202 +Abnormal saccadic eye movements 10 26 2.1002760209580345 0.035704567373088 6.293689320388349 24.570388349514563 0.6352395547829492 0.4765898942028741 2.9458970942458165 3.3125821982342476 0.9514629694011908 0.3397171221111555 0.020630000046661 1.0 0.4825947600252522 0.2256891642594976 0.0166822263622692 +Muscle abnormality related to mitochondrial dysfunction 14 36 2.0996967973799525 0.0357555215014415 11.12378640776699 35.58252427184466 0.9791864828781052 0.3365990386989574 4.6259837298613 4.333263242301439 1.4740065920951253 0.3430734831138388 6.609438495348992e-05 0.0038595506966638 0.0004161253072624 0.0001757554739234 6.714026824979541e-05 +Wide cranial sutures 1 7 2.099665665881323 0.0357582618856553 2.0145631067961167 7.703883495145631 0.7152221419680245 0.3932675421341624 1.400340303092121 0.8783725385755785 0.8965275088954128 0.2767752142477642 0.1374503862977756 1.0 0.0100519320580488 0.0557098434243155 0.1807018090276839 +Delayed cranial suture closure 10 29 2.0987685339500013 0.0358373099025943 7.716019417475728 29.325242718446603 0.7058204487281402 0.4787858893421486 2.9402522313721624 1.8749870392614547 0.9549766649562498 0.3518038054905379 0.0005265614813032 1.0 0.107004894081217 0.0127222619547071 9.026170863058632e-05 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5.424757281553398 21.550970873786408 0.2837846270756372 0.4096308965627429 3.0903339262997473 2.8582743162812116 1.1598915940568888 0.2934678757183479 0.0044439773047646 1.0 1.0 0.0074685925596388 0.0110551101007063 +Abnormal talus morphology 11 21 2.0782741765944457 0.0376841134880285 5.240291262135922 19.174757281553397 0.4911811237390521 0.5442530018796214 2.7576949556766475 2.130122310477174 0.7867683210575629 0.3080636984525612 0.0356515059560401 0.1952735388158895 0.0091243340822671 0.0227330174276438 0.0055591316089767 +Bird like facies 1 7 2.0781283102222416 0.0376975427947823 1.2184466019417477 6.344660194174757 0.51600213874464 0.5009499380331454 1.3989765727245551 0.8519797795289369 0.7670036187450932 0.2677008423131485 0.0966882498554272 1.0 0.0066572828402184 0.0379575415698398 0.1289341732663725 +Peripheral axonal neuropathy 16 57 2.0777897565266943 0.0377287277102309 13.890776699029129 56.6626213592233 0.647996206639266 0.5297865267121298 5.546380992609976 6.858150910061315 0.9851361073340408 0.3701043540632976 0.0011425117170359 0.1354750356227081 0.3700525131557232 0.2226406444315481 0.0002546834527184 +Chronic diarrhea 4 20 2.075445921837167 0.0379452259038408 4.514563106796117 18.550970873786408 0.2309588263877121 0.4319883908654413 2.0282666456418785 2.0703229027090826 1.177819281609388 0.3206617066576645 0.0419220169184899 1.0 0.3655284832956332 0.1038817567329197 0.0762091064419948 +Confusion 7 17 2.0741368139687664 0.0380666064282615 4.924757281553398 17.62378640776699 0.5770193034786405 0.489615172337713 2.480343831732211 2.1535063377225914 0.8853427180085949 0.3168581188371634 0.0117208488949189 1.0 1.0 0.3140672800286707 0.0070893533545687 +Retinopathy 7 29 2.0684769574317623 0.0385951951975318 7.716019417475728 27.516990291262136 0.7648928031827923 0.4912060355555205 3.3040774573673595 3.4588008851352714 0.8590527654816497 0.3424638793573584 0.0173772261861542 1.0 0.1827953867238 0.1316996895499912 0.042276670816049 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21.259708737864077 0.4368319789530849 0.4886321385908432 2.9093144657736354 3.168109894482179 1.024724777664989 0.3264729071151926 0.000354880510298 1.0 0.3467918934582977 0.0039562767661884 0.00110124435718 +Hypersplenism 3 7 2.065082839413688 0.0389151628361001 2.7184466019417477 7.970873786407767 0.2142260937784027 0.1548364087136437 1.1589036979530396 1.1444786041391362 1.8316571038254568 0.2005205006822401 0.0033918567435536 0.0742352733278267 0.000440337804097 0.0004788146962384 0.0062633876942655 +Left ventricular systolic dysfunction 2 7 2.0560564794315392 0.0397770725012329 2.0024271844660193 6.274271844660194 0.8306323903703577 0.3188570764916028 1.4472920586220064 1.367095356040773 1.072243004538969 0.2702909744520516 0.0587858303044749 1.0 0.018640880521655 0.097689242801984 0.088385561156941 +Polyhydramnios 15 50 2.055035459723415 0.0398755798637422 9.725728155339803 48.72572815533981 0.4441665430084449 0.6080023046732861 4.645701448168829 5.271283092441876 0.7577673236249489 0.3332605778262915 0.046123666529235 1.0 0.0809872682181705 0.0219741093976294 0.0369861430018694 +Abnormal lung development 17 48 2.05408415439978 0.0399675474171772 10.679611650485436 46.64563106796116 0.3425965834624591 0.6525956467022481 4.313477618995258 5.08859903467878 0.6930330626799799 0.3203786360367541 0.0453786715483253 0.5194592783315142 0.0574136821119774 0.029796887215469 0.0319596055269751 +Thoracic kyphoscoliosis 1 6 2.053085117205116 0.0400643231107016 1.3033980582524272 5.87621359223301 0.6447732028170892 0.4007730485565953 1.3447806717609607 0.3293377187920246 0.9322309909828016 0.2786816030415287 0.0719012577032834 1.0 0.0047533286028597 0.0276231155809849 0.0968157430558884 +Cerebral inclusion bodies 4 14 2.051575321141165 0.040210952633404 3.844660194174758 13.655339805825244 0.5051551663301821 0.4226246963159299 1.8115448621120656 1.6612796655742368 1.090041660052819 0.3107400387490911 0.0442625920896186 1.0 0.0398064357050217 0.1887844423268079 0.0203628052401783 +Limited wrist movement 2 6 2.047978315261592 0.0405621242181282 1.3519417475728157 5.033980582524272 0.5996596677114278 0.4085363950174713 1.0882965742387771 1.0765869657248284 0.9224773457089386 0.2739378776344282 0.0065740916466848 1.0 9.839858993160587e-05 0.0014684283121974 0.0105668672564949 +Abnormal pericardium morphology 4 11 2.0439043107163224 0.0409630012132635 3.487864077669903 10.762135922330096 1.0304485268572945 0.2849705132346721 1.7172308655515107 1.695717994097398 1.0794817436655069 0.2735310781030822 0.048607244419577 1.0 0.0041517217414646 0.0479498850625808 0.0229507437408614 +Varicose veins 1 7 2.043849260750207 0.0409684409667114 1.449029126213592 5.400485436893204 0.5039016792864417 0.4504533293589469 1.1657840518133464 1.015558460972087 0.9378322272027768 0.2968584263412278 0.2265412972075606 1.0 0.191600110602388 0.097689242801984 0.2898287915273368 +Delayed menarche 2 6 2.043266132016676 0.0410261003292911 1.4368932038834952 5.902912621359223 0.7389673790988543 0.4143069251494963 1.3841677806195565 0.2960767122713962 0.8197794755875409 0.2784352424195064 0.0021018851435908 1.0 0.0018609890552042 0.0004519701832281 0.0034377129995212 +Absence of subcutaneous fat 1 7 2.03046697970986 0.0423090943172503 1.2402912621359223 6.266990291262136 0.6349220737938032 0.4738544263011487 1.4641435790320352 0.7830595148449672 0.753994738483436 0.2801939975893033 0.0966882498554272 1.0 0.0066572828402184 0.0379575415698398 0.1289341732663725 +Abnormal protein glycosylation 7 20 2.0291553122171706 0.0424424735878794 4.992718446601942 17.04854368932039 0.4349711267577257 0.4629072595890348 2.62316887373748 2.93994465563356 1.0108477090998502 0.3020677841214376 0.0005424728900273 1.0 0.2941077913158182 0.0106277501006418 0.0014896299843671 +Abnormal arterial physiology 9 27 2.028286613489198 0.0425310044087436 6.218446601941747 26.953883495145632 0.6799967252485163 0.4871419269266132 2.869465887610158 2.4604264895945303 0.8630108658008876 0.3264277839815205 0.0118914979767538 1.0 0.2178091494673695 0.1770898669719441 0.0125470884313581 +Ventricular preexcitation 3 6 2.027994064445941 0.0425608537975179 2.5145631067961167 6.497572815533981 0.9841118497305948 0.2225227126053997 1.468861772329754 1.5757549992030588 1.3097679632537274 0.2453287763295943 0.0065553535310396 0.0875404472016038 0.1677870330809631 0.0757571260003459 0.0118865434534573 +Submucous cleft of soft and hard palate 5 18 2.025537428741707 0.0428122091854945 5.138349514563107 22.941747572815533 0.8980380147163236 0.4007892874523231 2.272201189765468 2.581958475140233 0.7850752745431548 0.2945527466716488 0.0431895834814261 1.0 0.1226746045160812 0.0177220872628324 0.0322356046235818 +Arteriosclerosis 6 14 2.0248319889347086 0.0428846191272642 4.885922330097087 14.944174757281552 0.0721468675738393 0.2032976413320727 1.852339343238996 2.0572604199467093 1.788928597657784 0.2405012300780825 0.003138705966493 1.0 0.0011293669878184 0.0057706709278987 0.0079620077053278 +Coronal craniosynostosis 2 7 2.0198356409510216 0.0434004388619058 1.9975728155339805 5.660194174757281 0.3156922157886654 0.516342594521945 1.3247069403108018 1.1474192067777893 0.8923097804196743 0.2970323626650711 0.0350962772824537 1.0 1.0 0.3559534457378639 0.0539281835546241 +Phenotypic variability 30 101 2.0180152112186844 0.0435896771497008 22.339805825242717 99.4368932038835 0.8464119152872666 0.5170730885331468 8.500203764614474 8.607030207254683 1.0360918895927824 0.3938137781932724 0.0342934754016952 0.0429933331741239 0.0050024453894193 0.070875217151372 0.0040524001964041 +Limb muscle weakness 22 85 2.0178498600607813 0.0436069002966816 17.839805825242717 80.70388349514563 0.4827776345811875 0.6059822076523635 6.801525240221059 8.816890479868707 0.7698087425405967 0.3425134280672268 1.0472260798296496e-05 1.0 0.1347944849764237 0.0108927752408549 1.9268881172514363e-05 +Parkinsonism 8 30 2.0171332699701296 0.0436816075048283 7.453883495145631 30.097087378640776 0.7249761134976155 0.4663275088289313 3.116711838694066 3.708464636913605 0.8967824567735009 0.3291722600978801 0.0240712499264443 0.3403437958043751 0.0497306095082375 0.0566012047710065 0.0232519938279594 +Biliary cirrhosis 1 7 2.0159678042247644 0.0438033425417168 1.9733009708737863 6.650485436893204 1.1218722294682368 0.279893930524248 1.1603338056285764 0.598683634692072 0.8535321112514973 0.2502325498718601 0.0840134225210092 0.0561990347849709 0.1094892401774078 0.032628233248221 0.1125747569923622 +Unexplained fevers 1 5 2.0113013294484734 0.0442936381710463 1.5388349514563109 5.621359223300971 0.7467355824508212 0.3321409792965325 1.0149114466807625 0.7710351742240161 1.1275544850735062 0.2907731941603199 0.0840134225210092 0.0561990347849709 0.1094892401774078 0.032628233248221 0.1125747569923622 +Calcinosis 3 5 2.0083868381840726 0.0446022004385924 1.5072815533980584 5.099514563106796 1.1513451038285936 0.2590169313384529 1.041584579038491 0.4030222683885372 0.953608514142629 0.2639318719258676 0.0065740916466848 1.0 0.0039135152062846 0.0014684283121974 0.0009118158302113 +Prenatal maternal abnormality 7 14 2.0077108138458617 0.0446740308353712 3.2184466019417477 13.143203883495143 0.9929636287681164 0.3563834047543391 1.88526465772658 1.4026249411092802 0.7410557762145566 0.2726392168397587 0.3119171194586682 1.0 0.4876012483283494 0.2320869702147383 0.2430359635228135 +Abnormal circulating non proteinogenic amino acid concentration 3 7 2.00469717705121 0.0449954305039654 2.162621359223301 6.968446601941747 0.7521093084296674 0.2992197670299059 1.410866607722538 1.225329167014724 1.1887948503174883 0.2730524920497975 0.0026277975298375 0.0697581245313758 0.1349531130589082 0.0495157384890535 0.0048822579474643 +Cachexia 4 19 2.0029738238028645 0.045180098186468 4.371359223300971 18.25485436893204 0.1308736058795594 0.3437329688633732 1.963367203014057 1.8448565940413904 1.2969303512721055 0.2680999243445657 0.0419220169184899 0.2030241760545403 0.0010428679183072 0.0052710570752827 0.0762091064419948 +Mitochondrial myopathy 10 29 2.0020570712689976 0.0452785938246584 9.186893203883496 28.17233009708738 0.8747125393417822 0.3473011798108487 3.936575202939786 3.974666305559559 1.3336232032537867 0.3216890657230479 0.0002259538298281 0.0257535715284909 0.0015259573241502 0.0014919193154812 0.0001665225081846 +Abnormal visual electrophysiology 12 47 2.0009863517896447 0.0453938607261936 11.310679611650484 49.08009708737864 0.5738496712827478 0.4298926605512212 5.601714588788375 4.822166856762376 1.2686017151039417 0.3684491475281102 0.033916295791706 0.1520007577137938 0.4042257707765572 0.0596487583268479 0.0472801268480885 +Hemivertebrae 4 12 1.9996687421358923 0.0455360456118665 3.512135922330097 11.783980582524272 0.6301475240174538 0.4485350988347466 1.996926838183888 1.5262860818032955 0.9074280753889176 0.307982460828651 0.0184470952138011 0.1675604235637086 0.3076603852203092 0.0630731351339203 0.0353817250131281 +Stroke like episode 4 6 1.9971507927799077 0.045808804644335 1.9320388349514563 5.347087378640777 0.7802983779647638 0.3377286829697849 1.3402806250303152 1.5433591727314462 1.1185957061594276 0.2970042406174105 0.0042940863146269 0.0786913117950012 0.1515272625734178 0.0621585272883563 0.0078812527225172 +Hammertoe 8 20 1.992341351293187 0.0463336175420892 3.662621359223301 18.046116504854368 0.6966488433366873 0.4834332623162832 2.346296590711119 2.471254047837027 0.8432277041521599 0.3207676556555462 0.005322180347797 1.0 0.3209553841799009 0.2511786735203468 9.884573920484636e-05 +Abnormality of prothrombin 4 13 1.9920015822480857 0.046370884280336 4.5 13.25242718446602 0.3265563085399564 0.5312916537639599 2.2071155890213294 1.527854302271569 0.8954775795358557 0.3100216206843308 0.0050390336340173 1.0 1.0 0.0042924995678 0.010278445998416 +Upper airway obstruction 3 5 1.9911672485508296 0.0464625032122412 1.7378640776699028 4.395631067961165 0.9757524179748694 0.272585161266212 1.0188625396632285 0.5317860908423824 1.0518772900465188 0.2586596530104152 0.0143018721877003 1.0 0.0066572828402184 0.0379575415698398 0.0027630263410089 +Erythema 7 21 1.9899766939607344 0.0465935029020825 5.512135922330097 21.009708737864077 0.7860124479392929 0.4207309091489555 2.592436403423807 3.539637263054128 0.9160883902281578 0.3036972678357262 0.0063072048087653 0.2801168002074996 0.1388614812827933 0.0238750792658836 0.0166822263622692 +Abnormality of the larynx 11 45 1.9858833908539515 0.0470462733728636 10.682038834951456 46.699029126213595 0.7426785971038559 0.4816723930500222 4.067795342682343 4.403407664230521 0.9382180075001202 0.3633154044529258 0.0817567627776552 0.1587221484945262 0.0540831694948363 0.0670546193669445 0.0560972756343272 +Chronic pulmonary obstruction 2 9 1.9784958211058563 0.0478727995541647 1.7912621359223302 6.975728155339806 0.7151400882135658 0.3422892186915894 1.3201652438579738 1.3051032038511063 1.0511250125541778 0.2765518721331778 0.0461853959222372 0.0919337377678228 0.1758008751515455 0.0828772873031817 0.0701952648708137 +Paresthesia 9 25 1.97721581133304 0.0480172411179899 5.66747572815534 23.635922330097088 0.7476018604198311 0.4719429115693522 2.535880467324221 3.039141242047335 0.8424234714329004 0.3217041155902614 0.0112497451158167 1.0 0.5166489093314391 0.5437935802005475 0.0032173368963242 +Preaxial hand polydactyly 4 10 1.9767768958366017 0.0480668543852564 2.674757281553398 9.485436893203884 0.4590337046439506 0.5098265109052856 1.6043156873205788 2.184962187448707 0.8020748248618365 0.2852380317097359 0.0387091267043979 0.1991580424676108 0.0720571885403784 0.0244406528674846 0.0707827064406983 +Microcytic anemia 2 8 1.975860577159716 0.0481705702488743 2.441747572815534 8.526699029126213 0.6645628317552182 0.3838242289014166 1.6704179043327654 1.438636684975842 1.0496853438983738 0.3012783873714112 0.0656286176794259 1.0 1.0 0.0172025832638257 0.0981468657129251 +Tissue ischemia 7 20 1.9732236938365948 0.0484700821352193 4.669902912621359 20.01941747572815 0.4670703905456849 0.5376214087969519 2.554791232762714 1.8952192409705757 0.8387891641382008 0.309595447618788 0.0291943450773249 1.0 0.1554832015057707 0.2579811764447431 0.024623627475093 +Tetraplegia tetraparesis 13 43 1.9727132082987244 0.0485282462588481 10.143203883495143 47.300970873786405 0.4344357558868983 0.567203274478056 4.333363166995388 3.887582800182895 0.8586009205254926 0.3435411784062096 0.0106271491309871 0.0904452781629929 0.0801526286479979 0.0413515024466966 0.0016584439445074 +Arthralgia 10 33 1.9694742488070105 0.0488986568432046 8.067961165048544 33.66019417475728 0.4973169065736986 0.5336317295986659 3.339269543758109 3.852381429809718 0.8994568503620952 0.3283969638661596 0.11042694461881 0.3807425591661329 0.0150746255638078 0.0909960920222553 0.0083663437778731 +Aplasia hypoplasia of the nipples 5 18 1.9683272836463768 0.0490303926474213 4.730582524271845 16.33495145631068 0.1401317124641657 0.6708038962730689 2.566160792714192 2.3595379150165803 0.6450557830977582 0.2725671104794809 0.0035731284747819 1.0 0.3009165941166509 0.0116952906397438 0.0081853110588452 +Stillbirth 5 11 1.9683087103219163 0.0490325283531867 3.145631067961165 11.177184466019416 0.7032160695176418 0.4106957336237037 1.7385283755040757 0.8562527499503464 0.8448273274133665 0.2731066189783109 0.0001450821031219 1.0 0.0010099703116007 0.0001164002838048 0.0003689915939861 +Abnormality of the vasculature of the eye 14 74 1.966280476330538 0.0492662207879122 16.27912621359223 72.06553398058253 0.403343228775578 0.4479390001832676 5.629952078086087 5.671259209870798 1.3806507490937323 0.3789287537753926 0.0248628851826348 0.0962045324719342 0.176363523212896 0.0496104418903072 0.0518775451848926 +Metatarsus adductus 6 13 1.965054514531409 0.049407928338707 3.7694174757281553 13.25 0.9957104022100554 0.3572272245833284 1.816252583500775 2.104808410901558 0.7948300017734555 0.2882447196496276 0.1509164607438732 1.0 0.2732850813359189 0.1887844423268079 0.0203628052401783 +Accessory spleen 3 7 1.9650421396216968 0.0494093604820966 1.966019417475728 6.861650485436893 0.274531928254225 0.5475741379706007 1.4172346516633685 1.1732393105335834 0.8284916786232522 0.288909257936624 0.0153022136017921 1.0 0.2070995190727305 0.1131762501747812 0.0269295467729808 +Foot dorsiflexor weakness 12 33 1.963191751545576 0.0496238974427021 6.871359223300971 31.803398058252423 0.5722811231484813 0.5519136473671545 3.234440738423893 3.8012118796735064 0.7842026565791261 0.3226099174033894 4.104257220970471e-05 1.0 0.1588529428511447 0.0328918504861857 4.897211079555433e-05 +Abnormal speech prosody 1 7 1.963071527417724 0.0496378634100289 1.7184466019417477 7.531553398058253 0.8238611105871386 0.3292070194756458 1.3593793253030109 1.1305443806694235 1.0768574157850217 0.2870822069632543 0.1517587358910909 0.0786913117950012 0.0113213926532688 0.0621585272883563 0.1985866733922443 +Focal t2 hyperintense brainstem lesion 4 18 1.9629778538801752 0.0496487473838205 5.745145631067961 17.558252427184467 0.7787968952644161 0.3563659539921697 2.720936576360794 2.4403574571781053 1.1656572167307155 0.3009968442621839 0.0078803131844108 0.0096266028600564 0.0002069103237917 0.0007982079470274 0.0033138804057902 +Generalized myoclonic seizure 12 39 1.9626841645755304 0.0496828842627639 9.177184466019416 40.04854368932039 0.4529392195590967 0.4207459458757411 3.6022058822892773 4.354728800706526 1.2466313924241157 0.3493918392140687 0.0263290916904006 0.114689393659792 0.0290362076287452 0.0270561912398673 0.0143684953141881 +Respiratory arrest 3 7 1.9625551043467684 0.0496978917604142 2.0558252427184467 7.070388349514563 1.3186130117670736 0.2232983865916446 1.389730031946098 1.4320861436977392 0.8270726521635177 0.2287950263954721 0.0350962772824537 1.0 1.0 0.3559534457378639 0.0539281835546241 diff --git a/msigdb_hp/metrics.json b/msigdb_hp/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..876257ee085f0cd8d51847fba1f180f83b323900 --- /dev/null +++ b/msigdb_hp/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3221, + "annotations_size": 4579, + "title": "Average number of proteins per term", + "value": 23.86896702336755 +} \ No newline at end of file diff --git a/msigdb_hp/paths.json b/msigdb_hp/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..5b888db0c3d661205cf163ae1e3d7b493d40ba25 --- /dev/null +++ b/msigdb_hp/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/msigdb_hp/fragment/C201/C201_val_log2fc"} \ No newline at end of file diff --git a/msigdb_hp/result.tsv b/msigdb_hp/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..7d76003d6f87d2b52108c2d057ba41ce19cbe191 --- /dev/null +++ b/msigdb_hp/result.tsv @@ -0,0 +1,1979 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Biliary tract abnormality 0.7864304146519343 3.718373947782113 0.0002005093027028 0.600772622664179 0.4188955019598143 26 P02545,P07602,P09601,Q5XKP0,O43681,Q9NZJ7,P04062,Q10713,Q14108,Q14739,O95202 11 +Abnormal biliary tract morphology 0.7923846562838698 3.697783186455162 0.00021749052756 0.6306451484158357 0.4188955019598143 23 P02545,P07602,P09601,Q5XKP0,O43681,Q9NZJ7,P04062,Q14108,Q14739 9 +Dementia 0.62707926369775 3.634628039144544 0.0002783819785896 0.7205378850006792 0.4188955019598143 56 O60313,O43681,P06865,P03886,Q96RL7,P07602,P17900,P00403,P05067,Q13510,O96008,P35670,O15118,O76024,P20700,P61916,P04062,Q14108,Q9UBB4,Q9NZJ7,Q9Y487 21 +Mental deterioration 0.5740252546403383 3.4186182146127018 0.0006293997080282 0.9440293938079228 0.4188955019598143 92 O60313,O43681,P54802,P06865,O43819,Q10713,P03886,Q96RL7,P10644,P16278,P50897,P07602,P17900,P00403,P05067,Q13510,O96008,O95470,P35670,O15118,O76024,P20700,P04062,P61916,O75503,Q14108,P21912,Q9UBB4,Q5XKP0,Q9NZJ7,Q9Y487,P21964 32 +Abnormal circulating lipid concentration 0.5547441304629739 3.3981645142811883 0.000678396114192 0.95528427101089 0.4188955019598143 77 Q9NVI7,Q15392,P09622,Q15800,P40855,P40939,Q16836,P22830,P07602,P50402,Q9Y4P3,P06280,Q03252,P50416,O95470,Q9UBM7,O75844,P02545,P61916,Q15125,O75431,P23786,Q14739,Q8N511,Q9UJS0,P37268,Q15904,Q9NZJ7,O75880,O75381 30 +Abnormality of femur morphology 0.5213416356284474 3.1986301770133063 0.0013808217676878 0.9982128841489676 0.4188955019598143 66 Q9BXW9,Q7LGA3,Q9UHX1,P55011,O00754,P16278,P07602,P06280,P51798,Q04656,P16435,O75844,P02545,O95831,P04062,P51812,O75431,Q14739,Q96HY6,P04637,Q9NZJ7,P38398,Q96A33,O00116,Q9Y487,Q9Y619 26 +Clumsiness 0.7033816477833206 3.14941264266253 0.0016359901202676 0.99944543870475 0.4188955019598143 23 P07602,O43681,O00165,Q9NZJ7,Q13510,O75503,O43819,P35670 8 +Left ventricular hypertrophy 0.6904847437401272 3.0812898220553224 0.0020610592719814 0.9999211000139736 0.4188955019598143 24 Q6NUK1,P06280,P00403,P10253,O75880,O75787,O75208,P12235,P03886,P40939,O75431 11 +Abnormal retinal artery morphology 0.6917988529167951 3.075290282361304 0.0021029776590977 0.9999349057453712 0.4188955019598143 23 P16278,P07602,P17900,Q9Y4P3,Q9NZJ7,Q13510,P10619,P03886,P21964 9 +Poor head control 0.512895387670615 3.064176046774739 0.0021827042526392 0.9999548502719756 0.4188955019598143 70 Q9P0J0,P06865,Q10713,P53007,P03886,O43676,P07602,P17900,Q96CU9,Q5KU26,Q86Y39,P02545,P57678,P13073,O95299,O96000,Q9Y6M9,P21912,Q9NWM8,Q5XKP0,Q9NZJ7,P51970 22 +Corneal opacity 0.5649535844782579 3.0481689392659375 0.0023024044969974 0.9999739336577512 0.4188955019598143 55 Q9NVI7,P10619,P40855,P16278,Q6NUK1,Q9Y4P3,P06280,O96028,Q13510,P51648,P35670,O95202,O75844,P02545,Q96J42,P04062,Q15645,O75381,Q5H8A4,Q06136 20 +Toe walking 0.6838647666010128 3.0383371023397956 0.0023788767915251 0.9999816495015228 0.4188955019598143 24 P02545,P07602,O95831,O43681,P50402,Q9NZJ7,P53007,Q6UWE0,Q99720,P40939 10 +Ventricular hypertrophy 0.6335792228418476 2.9767026968435615 0.0029136640579252 0.9999984248217654 0.4188955019598143 38 O75844,P02545,Q6NUK1,P35573,P06280,P00403,P10253,O75880,O75787,O75208,P12235,P03886,P40939,O75431,P23786 15 +Increased bone mineral density 0.666030546712393 2.9512499281757054 0.0031649071070252 0.9999995032064234 0.4188955019598143 26 P02545,Q15392,Q15125,Q9Y4P3,P54802,Q15043,P04062,Q13126,Q14108,P51798 10 +Bulbar signs 0.8181918337100377 2.945249621142328 0.0032269420448103 0.9999996263924622 0.4188955019598143 12 P07602,Q9NZJ7,Q15043,P04062,Q99720,P03886 6 +Abnormal left ventricle morphology 0.6565499866486048 2.9204062292205952 0.0034957538092743 0.9999998913463388 0.4188955019598143 28 P21912,Q6NUK1,Q15645,P06280,P00403,P10253,O75880,O75787,O75208,P12235,P03886,P40939,O75431,O60566 14 +Horizontal nystagmus 0.6791783192823546 2.918445481456456 0.0035178138394527 0.999999901820538 0.4188955019598143 22 O60313,O95831,P07602,P20700,Q9H061,O94905,Q9NZJ7,P04062,Q9NW15,O00203 10 +Young adult onset 0.8303907774214976 2.9065144857558787 0.00365479976305 0.9999999476851188 0.4188955019598143 11 O15118,P02545,P07602,Q9NZJ7 4 +Abnormality of hepatobiliary system physiology 0.5098556290545847 2.9008908848953605 0.0037210342486395 0.9999999614147332 0.4188955019598143 81 Q9BT22,O75787,P09622,O43819,Q10713,P40855,P22695,P03886,P40939,Q16836,P22830,P39210,Q13510,P50416,P35670,O15118,P04062,P23786,Q8N511,Q5XKP0,Q96A33,O75381,Q9Y619 23 +Hyperintensity of cerebral white matter on mri 0.6922911343062307 2.8615445182200117 0.0042158229181188 0.9999999960322216 0.4188955019598143 20 P07602,P20700,P17900,O43681,Q96AA3,Q9NZJ7,Q15043,P10253,O75503,P21912 10 +Abnormalities of placenta or umbilical cord 0.7372719465031171 2.830538980675068 0.004646964826761 0.9999999994538054 0.4188955019598143 15 P16435,O75844,P02545,P16278,O43175,Q12768 6 +Sensorimotor neuropathy 0.6292908401858375 2.825794989568036 0.0047163438822799 0.9999999996030564 0.4188955019598143 33 O60313,P07602,P07196,Q9NR77,Q9NZJ7,P00403,Q5KU26,P39210,Q9Y2R0,P05023,P03886,P40939 12 +Abnormal tissue metabolite concentration 0.730583802151582 2.7926740331498574 0.0052274339520748 0.9999999999622186 0.4188955019598143 15 P07602,P17900,O43681,P06280,Q9NZJ7,P40855,O75381 7 +Osteoarthritis 0.804781399143058 2.7784176199029234 0.0054624362396167 0.9999999999871934 0.4188955019598143 11 O75844,P02545,P04062,Q14108,P35670 5 +Abnormality of extrapyramidal motor function 0.4894991596400174 2.7738110635085023 0.0055403844805854 0.9999999999910552 0.4188955019598143 74 O14949,Q9H9P8,O75787,P06865,Q96RL7,P16278,P07602,P17900,Q9Y4P3,P05067,O96008,Q96IX5,Q15043,P04062,Q99720,Q9BPX6,Q9H6K4,Q9UBB4,Q9NZJ7,P12235 20 +Abnormal peripheral nervous system physiology 0.5536551568232535 2.771679561573624 0.0055767904870318 0.9999999999924358 0.4188955019598143 51 O60313,Q9UBB4,P02545,P07602,O95831,P20700,P07196,O43681,Q9NR77,Q8TB36,Q9NZJ7,P39210,O15269,Q9Y619,Q6UWE0,Q99720,Q15125,Q96RL7 18 +Impaired proprioception 0.5913114921729932 2.768122593434206 0.0056380243277727 0.9999999999942945 0.4188955019598143 42 O00400,O75298,P20700,P07196,Q9NR77,O95140,O00165,O94905,P54802,Q8IV08,Q12768,O43819,Q9Y619,Q6UWE0,Q9H6K4,Q96RL7 16 +Ectopic calcification 0.525989380791977 2.743568069839157 0.006077544642314 0.9999999999992464 0.4188955019598143 56 O60313,P38435,P40855,P03886,P10644,O43175,P00403,P05067,Q9UBM7,P35670,Q04656,O75844,P02545,P04062,Q15125,O75431,P23786,Q14739,O00116,O75381 20 +Cherry red spot of the macula 0.8332152592907619 2.7368793129522992 0.006202504326715 0.9999999999995764 0.4188955019598143 9 P16278,P07602,P17900,Q9NZJ7,Q13510,P10619 6 +Peripheral demyelination 0.7204141617361677 2.734755934515626 0.0062426544106877 0.9999999999996478 0.4188955019598143 15 P07602,P20700,O43681,Q9NR77,Q8TB36,Q9NZJ7,P03886 7 +Periventricular white matter hyperintensities 0.8691895210379396 2.7346057899968916 0.0062455022689724 0.9999999999996524 0.4188955019598143 8 O75503,P07602,Q9NZJ7,P17900 4 +Decreased absent ankle reflexes 0.7094410805668533 2.7243612032691313 0.0064426003533082 0.99999999999986 0.4188955019598143 16 O60313,P07196,O75787,Q9H6K4,P12235,Q15041,Q96RL7 7 +Delusions 0.6954048396198121 2.6968296975043393 0.0070003061296828 0.9999999999999892 0.4188955019598143 17 Q13144,P07602,Q9UJS0,O43681,Q9NZJ7,P04062,P21964,Q96RL7 8 +Cns demyelination 0.7321909682289622 2.6926627486462857 0.0070883930389467 0.9999999999999928 0.4188955019598143 14 P07602,Q9NZJ7,P51648,P40855,Q5H8A4 5 +Optic disc pallor 0.5558462455704597 2.675641082068617 0.0074586473563924 0.9999999999999988 0.4188955019598143 48 O60313,Q9H061,Q10713,P03886,O43676,O00754,P04439,Q96CU9,O14656,Q86Y39,P51798,O95831,O96000,Q6P4Q7,Q9Y6M9,Q9H6K4,Q9UG56,Q8WWV3,O95140,Q96S66 20 +Progressive neurologic deterioration 0.6706205949213372 2.6633508024639405 0.0077366711959487 0.9999999999999996 0.4188955019598143 19 P16278,P07602,Q5XKP0,O43681,Q9NZJ7,P54802,P04062,Q10713 8 +Ragged red muscle fibers 0.6982695315075272 2.658996777637006 0.0078373712588968 0.9999999999999998 0.4188955019598143 16 O95831,Q70HW3,Q9H2D1,P00403,P12235,P03886 6 +Elevated pulmonary artery pressure 0.6262362011309368 2.6546205363522692 0.0079397667667313 1.0 0.4188955019598143 24 O75844,P02545,P20674,Q6NUK1,Q8IZA0,P00403,O96000,P04062,P51970,P03886,Q14108,P51798 12 +Macular degeneration 0.702381028222386 2.631022395891183 0.0085128425934692 1.0 0.4188955019598143 15 P04062,P50897,P51648,Q13510 4 +Supranuclear gaze palsy 0.6555355682107642 2.63077581272161 0.0085190212011538 1.0 0.4188955019598143 20 P07602,Q9NZJ7,P04062,Q99720,O15118,Q96RL7 6 +Impaired vibratory sensation 0.6018624290358326 2.626705352544178 0.0086215953089197 1.0 0.4188955019598143 33 O00400,O75298,P20700,P07196,Q9NR77,O95140,O00165,O94905,Q12768,O43819,Q9Y619,Q6UWE0,Q96RL7 13 +Progressive psychomotor deterioration 0.8457126130376278 2.6262234177398196 0.0086338126942626 1.0 0.4188955019598143 8 P16278,P07602,O43681,Q9NZJ7,Q10713 5 +Variable expressivity 0.4823005149130205 2.6248847938176754 0.0086678289781465 1.0 0.4188955019598143 80 Q15427,P07196,Q9NQT5,Q13509,Q9H061,P09622,P03886,P07602,P17900,P00403,Q13510,Q6P4A7,O95470,O14578,P02545,Q9NR77,Q70HW3,Q8TD16,Q15125,Q9Y263,O95140,Q9NZJ7,Q9UEY8,Q53H12 24 +Neck muscle weakness 0.6924638008967666 2.624818559000235 0.0086695152022227 1.0 0.4188955019598143 16 Q99720,P02545,P07602 3 +Ascites 0.6211327677308736 2.6197604963037846 0.0087991540578369 1.0 0.4188955019598143 24 P04062,P61916,O75787,Q13510,Q15645,Q14108,Q14739,O15118 8 +Aortic valve stenosis 0.806984441603007 2.6100057515445965 0.0090540700386245 1.0 0.4188955019598143 9 O75844,P02545,P04062,Q12768,Q15125 5 +Hypocholesterolemia 0.8409910636018553 2.6042501696936275 0.0092075521415719 1.0 0.4188955019598143 8 Q9NVI7,P07602,P37268,Q9NZJ7,Q15800 5 +Abnormal circulating cholesterol concentration 0.5958171164766616 2.602315006592652 0.0092596756635168 1.0 0.4188955019598143 34 P02545,Q9NVI7,P07602,Q8N511,Q9UJS0,Q15392,P50402,P37268,Q9NZJ7,P61916,Q15800,Q15125,O75431,Q14739 14 +Respiratory distress 0.5246943822626108 2.5975472499460492 0.0093892201484631 1.0 0.4188955019598143 53 Q9UHX1,O43819,P53007,P03886,P07602,Q96L58,Q13510,O95831,Q16134,O75648,P04062,P51571,P23786,Q9NZJ7,P10253,P53701,Q969X5,P51970,Q9Y619 19 +Abnormality of glycolipid metabolism 0.8701414432400462 2.578183435804541 0.0099321257651772 1.0 0.4188955019598143 7 P07602,P17900,O43681,Q9NZJ7,P06280 5 +Abnormal csf protein level 0.7475431913267756 2.5779322459249885 0.0099393484496335 1.0 0.4188955019598143 12 P07602,P20700,O43681,Q9NZJ7,P00403,P03886 6 +Mania 0.6843662566851927 2.5769073297626814 0.0099688672868218 1.0 0.4188955019598143 16 Q9UJS0,P00403,P12235,P03886,P21964,P16615 6 +Abnormality of head blood vessel 0.6089011331228957 2.5748102496423493 0.0100295092227018 1.0 0.4188955019598143 27 P16278,P07602,P17900,Q9Y4P3,Q9NZJ7,Q13510,P06865,P10619,P03886,P21964 10 +Schizophrenia 0.6463016560427003 2.5717613465902076 0.0101182614101451 1.0 0.4188955019598143 20 P07602,Q9NZJ7,P04062,P21964,P16615,O76024 6 +Orthostatic hypotension 0.7105973731252482 2.57154737657515 0.0101245161619833 1.0 0.4188955019598143 14 P07602,O43681,Q9NZJ7,P04062,Q04656 5 +Abnormality of epiphysis morphology 0.4871604183101996 2.570404885160462 0.0101579716696911 1.0 0.4188955019598143 60 P34059,P38435,Q7LGA3,P56589,P40855,P10644,P16278,Q96L58,O96028,P51798,Q9UBM7,Q04656,O95202,P16435,Q01968,Q5JRA6,O95831,Q96DX4,P51812,Q15125,Q14739,Q9UG56,Q96HY6,O00116,Q9Y2Q9,O15228,O75381,Q9Y619 28 +Abnormality of the umbilical cord 0.8681881447016948 2.569439224962188 0.0101863257569529 1.0 0.4188955019598143 7 O75844,P02545,Q12768,O43175 4 +Hepatic failure 0.5390397668028329 2.567916507465634 0.0102311795448641 1.0 0.4188955019598143 49 P22830,Q9Y619,P04062,P39210,P09622,Q13510,P35670,Q10713,P50416,P40855,P03886,P40939,O75381,P23786,Q16836,O15118 16 +Distal amyotrophy 0.4918440363876503 2.565110652364001 0.0103142906328757 1.0 0.4188955019598143 59 Q04656,P02545,Q9NVI7,P07196,Q9NR77,Q8TB36,P35573,Q9BQT8,Q8TD16,P39210,Q13510,O15269,P53007,Q6UWE0,Q99720,P21912,Q96RL7 17 +Abnormal lower motor neuron morphology 0.8319630352174354 2.5620696262067995 0.010405045661407 1.0 0.4188955019598143 8 Q13510 1 +Abnormal auditory evoked potentials 0.7969649231141887 2.5610121169727655 0.010436771604203 1.0 0.4188955019598143 9 O60313,P07602,P20700,Q9NZJ7,Q15125 5 +Abnormal chorioretinal morphology 0.6107650698342822 2.5607530841104813 0.0104445558642412 1.0 0.4188955019598143 25 Q8IY17,Q5XKP0,Q96J42,P04439,P53701,Q12768,P56589,Q10713,P40855,P40939,O75381,O43505,Q9Y619,Q01968 14 +Abnormality of visual evoked potentials 0.6440833341818273 2.557520398330915 0.0105421374899865 1.0 0.4188955019598143 20 O60313,P07602,O43681,Q9NZJ7,O75503,P51798 6 +Areflexia of lower limbs 0.6114328770155179 2.553094750369872 0.010677044636592 1.0 0.4188955019598143 24 O60313,Q16637,Q9Y223,O75477,P07196,Q9NR77,O95140,P50570,O75787,Q9H6K4,Q53GS7,P12235,Q15041,Q96RL7 14 +Hypoparathyroidism 0.7070428695570612 2.5514362888560735 0.0107279936446564 1.0 0.4188955019598143 14 P03886,P40939,P35670,P21964 4 +Avascular necrosis 0.642930152765155 2.5501075532201853 0.010768969109749 1.0 0.4188955019598143 20 O75844,P02545,P04062,Q9Y619,Q14108,P51798,Q04656 7 +Shoulder girdle muscle weakness 0.7245971079231066 2.54922423525687 0.0107962857478338 1.0 0.4188955019598143 13 P12235,Q8TD16,P07602,Q9NZJ7 4 +Pathologic fracture 0.7063533400563003 2.547529227042777 0.0108488764946914 1.0 0.4188955019598143 14 P04062,O15269,Q13126,Q14108,P35670 5 +Arthritis 0.5635575489913107 2.547262886577851 0.0108571608659771 1.0 0.4188955019598143 42 O75844,P02545,P21964,Q9NZ08,P06280,P10321,P04062,Q14739,Q13510,O15460,Q14108,P51798,P35670,Q96RL7 14 +Duplication involving bones of the feet 0.6412057163319052 2.5390100850477473 0.0111166618700213 1.0 0.4188955019598143 20 P21964,Q96J42,O96028,Q10713,Q15125,Q9UBM7,Q14739,O95202 8 +Laryngomalacia 0.703186456458217 2.5295607010944177 0.0114205417291872 1.0 0.4188955019598143 14 P02545,P21964,P07602,Q9NZJ7 4 +Airway obstruction 0.6670881129742943 2.5263818498697193 0.0115244144896107 1.0 0.4188955019598143 17 P16435,O75844,P02545,P09601,P06280,P21964 6 +Limb girdle muscle weakness 0.6053224996647926 2.522868678828026 0.0116401861015176 1.0 0.4188955019598143 25 O60313,P02545,P07602,P12235,O14979,Q8TD16,Q9NZJ7,P53007,Q13126 9 +Proximal muscle weakness 0.4605585297249092 2.5198810086882264 0.0117394512198449 1.0 0.4188955019598143 64 O60313,P07196,P51530,P53007,P50402,Q13510,P35670,P02545,Q8TB36,Q9BQT8,Q8TD16,Q99720,Q9BPX6,Q13126,P21912,O95140,P10253,P13473,P12235 19 +Hypotension 0.6077790163848039 2.5165474725535484 0.0118510933580935 1.0 0.4188955019598143 23 P07602,O43681,Q9NZJ7,P04062,Q13423,Q04656 6 +Incoordination 0.4603467524169319 2.5013918558842008 0.0123706217248336 1.0 0.4188955019598143 71 O43681,O75787,O14773,O43819,Q10713,P53007,P40939,P07602,Q13510,P35670,Q01105,Q9NR77,P04062,O75503,P21912,Q9UBB4,O95140,O00165,Q9NZJ7,P12235,Q9Y619 21 +Polyneuropathy 0.6350334647849084 2.499165855501244 0.012448603430569 1.0 0.4188955019598143 20 O60313,Q9HC21,P07602,Q15041,Q9NZJ7,P03886,P35670 7 +Abnormality of pulmonary circulation 0.5915059001942616 2.4806154708219506 0.0131155775509255 1.0 0.4188955019598143 29 O75844,P02545,P20674,Q6NUK1,Q69YQ0,Q9NZ08,Q8IZA0,P00403,O96000,P04062,P51970,P03886,Q14108,P51798 14 +Abnormal placenta morphology 0.814120118561045 2.4780593264014024 0.0132099178451874 1.0 0.4188955019598143 8 O75844,P02545,P16278,O43175 4 +Splenomegaly 0.4827371494535265 2.4644777816714303 0.0137213070282775 1.0 0.4188955019598143 94 Q15392,Q9BT22,P54802,Q10713,Q96RL7,P16278,P07602,Q13510,P51798,P35670,O15118,P02545,Q9NZ08,P04062,P61916,Q14108,Q14739,P04637,Q15904,Q9NZJ7,P10253,Q96A33,P21964 23 +Emg chronic denervation signs 0.6910721954514544 2.4604585876328566 0.0138759584897132 1.0 0.4188955019598143 14 O60313,P07602,O43681,Q9NZJ7,P39210,Q13510,O43819 7 +Hypopigmented skin patches 0.5871476170428312 2.449047848887526 0.0143234418789472 1.0 0.4188955019598143 29 P07602,Q9BXW9,Q8IZA0,Q9NP58,Q9NZJ7,P38398,P53701,Q15125,Q99828,P21912,P21964 11 +Abnormal vascular physiology 0.5169521822187884 2.4475410647258826 0.0143834733661147 1.0 0.4188955019598143 51 P20674,P03886,Q6NUK1,Q8IZA0,Q9Y4P3,P00403,P06280,P05067,O15460,P51798,O75844,P02545,Q69YQ0,Q9NZ08,O96000,P04062,Q14108,Q14739,Q9NWM8,P04637,P51970 21 +Abnormal muscle fiber morphology 0.4529683612799988 2.446974680673277 0.0144060958789264 1.0 0.4188955019598143 69 O60313,O96008,P02545,Q99720,O95831,P07196,P50402,Q70HW3,Q9H2D1,P00403,P05067,P53007,P12235,P03886,Q9BPX6,P23786,O43676,Q96RL7 18 +Global brain atrophy 0.6351993010930701 2.440133461625998 0.0146818366832921 1.0 0.4188955019598143 19 Q9NZJ7,Q9H9P8,Q9UHX1,P07602 4 +Decreased activity of mitochondrial complex iv 0.6671190215868732 2.4242768788080364 0.0153389057658588 1.0 0.4188955019598143 15 Q70HW3,Q9Y2R0 2 +Psychomotor deterioration 0.7684915211947483 2.4201506159036987 0.0155140797704327 1.0 0.4188955019598143 9 P50897,P07602,Q9NZJ7 3 +Abnormality of peripheral nerves 0.5363238420478389 2.4108004729041443 0.0159175537994731 1.0 0.4188955019598143 45 Q9UBB4,P02545,P07602,O95831,P07196,O43681,Q9NR77,Q8TB36,Q9NZJ7,P39210,O15269,Q9Y619,Q6UWE0,Q99720,Q96RL7 15 +Emg neuropathic changes 0.5873909621468332 2.4089851713949773 0.0159969479308976 1.0 0.4188955019598143 26 O60313,Q04656,P07602,O43681,Q9NR77,Q8TB36,O95140,Q9NZJ7,P39210,Q13510,O43819,Q96RL7 12 +Abnormal peripheral myelination 0.576726041360725 2.404636940027667 0.0161885397474046 1.0 0.4188955019598143 31 P02545,P07602,P20700,O43681,Q9NR77,Q8TB36,Q9NZJ7,P39210,O15269,P03886,Q96RL7 11 +Personality changes 0.6470904220592524 2.4038338637542473 0.0162241446925566 1.0 0.4188955019598143 17 P20700,P00403,P04062,P03886,P35670,Q96RL7 6 +Abnormal epiphyseal ossification 0.6549029438068071 2.400171594920302 0.0163873878562972 1.0 0.4188955019598143 16 Q9UG56,P10644,Q96HY6,P38435,Q96L58,O00116,O75381,P40855,Q15125,Q9UBM7,Q14739 11 +Abnormal cardiac ventricular function 0.6289135010395919 2.399881213515378 0.0164003929426894 1.0 0.4188955019598143 19 O75844,P02545,P00403,P10253,P09622,P12235,P03886 7 +Gait ataxia 0.4520956052283059 2.3992086208879675 0.0164305506544459 1.0 0.4188955019598143 72 Q9NVI7,P07196,O43681,Q9NW15,O14773,Q10713,P03886,P07602,Q03252,O15118,P20700,Q9NR77,Q14108,Q9UBB4,Q9NZJ7,Q9P0J1,Q8IV08,P12235,Q5H8A4,O75962 20 +Transposition of the great arteries 0.9043274590193512 2.3907667763353437 0.0168132293738509 1.0 0.4188955019598143 5 O75844,P02545 2 +Fluctuations in consciousness 0.8280880748738086 2.387852821895192 0.0169471270646799 1.0 0.4188955019598143 7 P04062,O43819,Q9UJS0,P03886 4 +Urinary urgency 0.7613499520377842 2.3844375254138774 0.0171052521057577 1.0 0.4188955019598143 9 O75298,P04062,Q12768,P20700 4 +Hip pain 0.9024214736327986 2.382841803832808 0.0171795751781376 1.0 0.4188955019598143 5 O75844 1 +Recurrent aspiration pneumonia 0.8587568645412581 2.378863155657806 0.017366121549357 1.0 0.4188955019598143 6 P04062,Q13510 2 +Morphological abnormality of the pyramidal tract 0.6160315226964156 2.3752793867006097 0.0175356714917533 1.0 0.4188955019598143 20 Q9UBB4,O00400,Q9H9P8,Q9Y4P3,Q12768,O75298,Q9Y619 7 +Nephropathy 0.5871777663433713 2.3735491831068627 0.0176180464917257 1.0 0.4188955019598143 23 P06280,Q10713,P03886,Q14108,O76024 5 +Abnormality of the phalanges of the toes 0.6585776723000983 2.373403790386477 0.0176249840635536 1.0 0.4188955019598143 15 O75844,P02545,P38398,Q7LGA3,O75431 5 +Central scotoma 0.7584892385381583 2.3700884351131686 0.0177838309916673 1.0 0.4188955019598143 9 O60313,Q8WWV3,O95140,Q9H061,O75306,P03886,Q9H6K4 7 +Orthostatic hypotension due to autonomic dysfunction 0.7577193757188876 2.366222620107441 0.0179706348204633 1.0 0.4188955019598143 9 P04062,P07602,Q9NZJ7,O43681 4 +Abnormal social behavior 0.4430381291883289 2.3643446555897527 0.0180620004848486 1.0 0.4188955019598143 67 Q9P0J0,O43681,Q9UHX1,P53007,P03886,O43676,P07602,Q96CU9,Q9Y4P3,P05067,Q5KU26,Q86Y39,O96008,O96000,Q9Y6M9,Q15125,Q5XKP0,O75746,Q9NZJ7 19 +Abnormal tongue morphology 0.4446530332145504 2.3561808179937995 0.0184639276448714 1.0 0.4188955019598143 69 P07196,Q9NQT5,Q7LGA3,Q10713,Q96RL7,O00754,P16278,Q6NUK1,Q9Y4P3,Q03252,Q99643,O15460,P48651,Q9UBM7,O75844,P02545,P20700,Q96J42,O75648,O75431,P21912,O94905,P10253,Q96A33 24 +Frequent falls 0.548878492942519 2.3514356046081484 0.0187011263101406 1.0 0.4188955019598143 39 P07602,O43681,Q9NR77,Q9NZJ7,P04062,O75787,Q13510,O43819,P53007,P12235,P40939,P21912 12 +Central apnea 0.8196261282814237 2.3490247190758953 0.0188226571717853 1.0 0.4188955019598143 7 P07602,Q9NZJ7,O76024 3 +Abnormality of lysosomal metabolism 0.8934328139734118 2.3453690470368245 0.0190082545655567 1.0 0.4188955019598143 5 Q13510,P07602,Q9NZJ7 3 +Myoclonic seizure 0.5003953186368457 2.3352066174434616 0.0195326296136375 1.0 0.4188955019598143 52 P16278,Q8WWV3,P07602,O43175,Q01105,Q5XKP0,P52788,Q9NZJ7,Q96N66,P04062,Q13510,O75503,P03886,P21912,Q9Y619 15 +Abnormal larynx morphology 0.5752232668185785 2.3343584465686034 0.019576960700401 1.0 0.4188955019598143 27 P02545,P07602,Q9NZJ7,Q13510,Q9UHX1,P21964,Q14739 7 +Hydrocephalus 0.4493787413794882 2.331590205567333 0.0197222595775532 1.0 0.4188955019598143 75 Q15427,Q9BXW9,Q15392,Q13509,Q10713,P40855,O60566,P10644,O00754,Q6NUK1,Q96L58,O96028,Q12768,P48651,P51798,Q9UBM7,O95202,P16435,Q96J42,Q8TAA9,P04062,Q15125,P23786,P50148,O95140,P04637,P38398,P53701,P21964 29 +Neuronal loss in central nervous system 0.7012700539673103 2.327995116397877 0.0199123629869188 1.0 0.4188955019598143 12 O15118,P04062,P07602,Q9NZJ7 4 +Abnormal heart valve morphology 0.4488779387000802 2.326098328088807 0.0200133057300804 1.0 0.4188955019598143 75 Q9UHX1,Q96PU5,P16278,P10644,Q6NUK1,Q9Y4P3,P06280,O96028,Q12768,P51798,O95202,O75844,P02545,P04062,P51812,O75431,P37268,Q8NCH0,P38398,P53701,Q5H8A4,P21964 22 +Peripheral axonal degeneration 0.4441731984227569 2.325215627510498 0.0200604331336442 1.0 0.4188955019598143 71 O60313,Q9NVI7,Q9HC21,P07196,O15269,Q6UWE0,P03886,Q96RL7,P07602,P00403,P39210,O76024,P02545,O95831,Q8TB36,Q9BQT8,Q9BPX6,Q9NZJ7,Q8IV08,P12235 20 +Cardiovascular calcification 0.7488738686814936 2.3216758921914065 0.0202503939989486 1.0 0.4188955019598143 9 O75844,P04062,P02545 3 +Hand polydactyly 0.555575822412396 2.317233816719088 0.0204909983367163 1.0 0.4188955019598143 35 P21964,Q96J42,Q9BXW9,Q9Y263,O96028,Q12768,Q9UHX1,Q10713,Q5H8A4,Q15125,Q9UBM7,Q14739,O95202 13 +Abnormality of the ribs 0.4386057730311438 2.315573636095704 0.0205815597048264 1.0 0.4188955019598143 67 P34059,Q15427,P54802,Q9UHX1,Q9UM00,O00754,P16278,O14656,Q96L58,O96028,Q12768,P48651,P51798,Q9UBM7,Q04656,Q01968,P16435,O95202,P02545,O75844,O95831,Q8TAA9,Q53GS7,O75431,Q14739,Q96HY6,P15586,P07237,Q5H8A4,Q32P28,Q9Y619 31 +Abnormal lung lobation 0.6659236226799734 2.315124969752142 0.0206060938784649 1.0 0.4188955019598143 14 Q9UHX1,Q15645,Q9UBM7,Q14739,P21964 5 +Abnormal elasticity of skin 0.4563558086088385 2.308887455531988 0.0209498272753489 1.0 0.4188955019598143 61 P38435,O75787,Q9UHX1,P10644,Q6NUK1,O43175,Q9Y4P3,P48651,Q04656,O75844,P02545,O96000,P04062,Q9NWM8,P04637,Q8NCH0,Q15904,Q9Y487,Q13126 19 +Juvenile onset 0.5275907285998427 2.3073934313321742 0.0210328970954396 1.0 0.4188955019598143 44 Q13144,P16278,P02545,P07196,P50402,Q9NR77,P06280,P54802,Q03252,P39210,Q13510,Q14566,O15118,P51798,Q04656 15 +Abnormal corneal epithelium morphology 0.6311779385213372 2.305005699981955 0.0211662541861901 1.0 0.4188955019598143 17 O75844,P02545,P39210,P51648,Q14739 5 +Middle age onset 0.7135708736947514 2.304943319913097 0.0211697480237424 1.0 0.4188955019598143 11 P02545,P07602 2 +Nasogastric tube feeding in infancy 0.7433556314765607 2.293764515650395 0.0218040286834269 1.0 0.4188955019598143 9 P07602,Q9UHX1 2 +Action tremor 0.4903198435264579 2.280583268186356 0.0225731183189068 1.0 0.4188955019598143 53 O43681,Q9NW15,O75787,O14773,P03886,Q5T8D3,Q96RL7,P07602,Q5JRX3,P20700,Q9NR77,Q99720,Q14108,Q8N2K0,Q9H6K4,Q9UBB4,O95140,Q9NZJ7,Q15233 19 +Entropion 0.7404386691130749 2.2789727776407536 0.0226686835710201 1.0 0.4188955019598143 9 O75844 1 +Degeneration of the lateral corticospinal tracts 0.8034323953799006 2.2742194911504945 0.0229527929087387 1.0 0.4188955019598143 7 O00400,Q12768 2 +Progressive spasticity 0.6417629093881828 2.272332568295378 0.0230664311379298 1.0 0.4188955019598143 15 O60313,P07602,P17900,O43681,Q9NZJ7,P51812 6 +Sensory neuropathy 0.5567908655967326 2.27184897795822 0.0230956334703862 1.0 0.4188955019598143 32 O60313,O95831,Q15041,O95140,P00403,Q8IV08,O15269,P03886,P40939,Q96RL7 10 +Thoracic scoliosis 0.6747682059749567 2.2706373546621204 0.023168940202501 1.0 0.4188955019598143 13 O75844,Q9UHX1 2 +Disproportionate short stature 0.5661422631358873 2.2683336321032965 0.0233088795309173 1.0 0.4188955019598143 27 P10644,P16278,Q96HY6,P34059,Q32P28,Q15392,Q96DX4,Q7LGA3,O00116,Q9UHX1,O15228,Q15125,Q9UBM7,Q14739 14 +Abnormality of the gallbladder 0.5290014181745779 2.264272105995806 0.0235573840954304 1.0 0.4188955019598143 42 P22830,P07602,O43681,Q9Y4P3,Q9NZJ7,P04062,Q96A33,P40855,Q5H8A4,P21964,O95202 11 +Cerebral dysmyelination 0.766717376032692 2.250647664632893 0.0244078619545902 1.0 0.4188955019598143 8 P07602,Q9NZJ7 2 +Epiphyseal stippling 0.6870831770445034 2.249826702613105 0.0244599482524718 1.0 0.4188955019598143 12 P10644,P38435,O00116,P40855,Q15125,O75381,Q14739 7 +Progressive spastic quadriplegia 0.7964895185011558 2.241946186503521 0.0249648504930444 1.0 0.4188955019598143 7 P07602,P17900,Q9NZJ7,O43681 4 +Underdeveloped supraorbital ridges 0.7015418505053709 2.240414655913095 0.0250640156885086 1.0 0.4188955019598143 11 P40855,Q6NUK1,O75381 3 +Clonic seizure 0.8265091840009458 2.2360163821491317 0.0253506980765179 1.0 0.4188955019598143 6 P07602 1 +Hyperconvex nail 0.7626399124756021 2.2307966090913123 0.0256946046706867 1.0 0.4188955019598143 8 P42892,O96028,P48651,Q9Y619,O95202 5 +Mucosal telangiectasiae 0.6995462611641121 2.2296614408746716 0.0257699275730047 1.0 0.4188955019598143 11 Q8IZA0,P06280,Q99643,P10619,P21912,Q14739 6 +Abnormal autonomic nervous system physiology 0.5531327071008251 2.2279357077835993 0.0258848026001226 1.0 0.4188955019598143 31 Q04656,P07602,O43681,P42892,P06280,Q9NZJ7,P04062,Q96RL7,O76024 9 +Ectrodactyly 0.6188513250736037 2.2276367454688897 0.0259047482377479 1.0 0.4188955019598143 17 Q99720,P07196,Q9NR77,Q8TB36,O96028,Q5H8A4,O95202 7 +Decreased activity of mitochondrial complex i 0.5509675392766151 2.227534800744866 0.025911552642811 1.0 0.4188955019598143 32 Q70HW3,Q9UBX3,Q86Y39,Q9Y6M9,P03886,O43676 6 +Prominent superficial blood vessels 0.6829009482162947 2.226643256361706 0.0259711255699852 1.0 0.4188955019598143 12 O75844,Q9Y487,P02545,Q6NUK1 4 +Abnormal gallbladder morphology 0.5459928105897437 2.223943719493129 0.026152231082005 1.0 0.4188955019598143 34 P22830,P07602,Q9Y4P3,Q9NZJ7,P04062,Q96A33,P40855,P21964 8 +Mixed demyelinating and axonal polyneuropathy 0.8640050267734689 2.2215498736652575 0.0263137406542968 1.0 0.4188955019598143 5 P03886,P35670,P00403 3 +Abnormality of skull ossification 0.6653784488079791 2.2170775245766934 0.0266177943583802 1.0 0.4188955019598143 13 O75844,P02545,Q6NUK1,P54802,Q14739 5 +Ankylosis 0.8629277971724802 2.216984296646314 0.0266241646355378 1.0 0.4188955019598143 5 P16435,P02545,O75844 3 +Abnormal nerve conduction velocity 0.5260646903681194 2.214326140652573 0.0268063516479437 1.0 0.4188955019598143 41 Q9UBB4,P02545,P07602,O95831,P07196,O43681,Q9NR77,Q8TB36,Q9NZJ7,O15269,Q6UWE0,Q99720,Q9Y619 13 +Increased cerebral lipofuscin 0.8621306668751959 2.2136043511106993 0.0268560077497934 1.0 0.4188955019598143 5 P50897,P07602,Q9NZJ7 3 +Chronic fatigue 0.7274587193423329 2.212835563902756 0.0269089844221122 1.0 0.4188955019598143 9 P07602,P04637,Q9NZJ7,Q5HYI8,Q13423 5 +Premature rupture of membranes 0.8614707899904913 2.2108054133981847 0.0270493148145389 1.0 0.4188955019598143 5 O75844,P02545 2 +Aplasia hypoplasia of the tongue 0.8613747159966697 2.210397832403989 0.0270775641117095 1.0 0.4188955019598143 5 P48651,Q96J42,Q03252 3 +Abnormality of the distal phalanges of the toes 0.8610122813498767 2.208860085219594 0.027184374236044 1.0 0.4188955019598143 5 O75844,P02545,Q7LGA3 3 +Scotoma 0.6795835894962182 2.208208676558949 0.0272297298449049 1.0 0.4188955019598143 12 O60313,Q8WWV3,O95140,P04439,Q9H061,P03886,Q9H6K4 7 +Decreased number of peripheral myelinated nerve fibers 0.6233862234503589 2.206844551112234 0.0273249213662349 1.0 0.4188955019598143 16 P02545,P07196,Q9NR77,Q8TB36,P39210,O15269,Q96RL7 7 +Abnormal visual fixation 0.7887995706091988 2.2060589038281955 0.0273798756743099 1.0 0.4188955019598143 7 P04062,Q13510 2 +Abnormality of retinal pigmentation 0.4332028294684121 2.2038315168551184 0.0275361952027735 1.0 0.4188955019598143 71 Q9P0J0,Q9UG56,P02545,Q96CU9,Q7KZN9,P00403,O95299,P51812,Q6P4Q7,P53701,P51648,Q96S66,P40855,P03886,P40939,O75381,Q16836,O76024 18 +Pericardial effusion 0.8178727465382996 2.1973572511338952 0.0279949418152309 1.0 0.4188955019598143 6 P04062,P02545 2 +Hypertrophic cardiomyopathy 0.4705733349195968 2.1968708383190125 0.0280296720733541 1.0 0.4188955019598143 106 Q9P0J0,O60313,Q9NVI7,Q9H061,Q7KZN9,P54802,Q99797,P09622,O43819,P03886,P40939,O43676,Q16836,P16278,P50402,Q96CU9,Q9Y4P3,P06280,P00403,Q86Y39,P50416,Q13423,P02545,Q96IX5,O95299,O96000,Q9Y6M9,P21912,Q5XKP0,P10253,P38398,P53701,Q53H12,P13473,P12235 35 +Abnormal thoracic spine morphology 0.5563485457797268 2.196550822079188 0.0280525417340538 1.0 0.4188955019598143 27 O75844,P02545,Q9UHX1,P51648 4 +Muscle spasm 0.4549230186622736 2.194492266835169 0.0282000392852661 1.0 0.4188955019598143 59 Q15165,O75298,P12235,O43175,P07196,Q9NR77,P06280,Q9NP58,P04062,Q12768,P13473,P05023,Q5H8A4,P40939,P23786,Q9H6K4 16 +Brittle hair 0.6287341530332389 2.1931714865943324 0.0282950260634926 1.0 0.4188955019598143 15 O75844,Q9NVI7,Q9Y487 3 +Generalized clonic seizure 0.8573080300485036 2.1931284621193496 0.0282981248927525 1.0 0.4188955019598143 5 P07602 1 +Impaired vibration sensation in the lower limbs 0.6607718308140615 2.190676331270972 0.028475223061013 1.0 0.4188955019598143 13 O00400,Q9NR77,Q12768,O43819,O75298 5 +Loss of speech 0.5964806341603497 2.1890472858534897 0.0285934033327832 1.0 0.4188955019598143 19 P50897,P07602,P17900,O43681,O94905,Q9NZJ7,P61916,O15118 8 +Raynaud phenomenon 0.8159218457402908 2.1886009231309553 0.0286258586763163 1.0 0.4188955019598143 6 O75844,P02545 2 +Macrovesicular hepatic steatosis 0.7524050372520315 2.18076508427795 0.0292007963262976 1.0 0.4188955019598143 8 P39210,O75431,P23786,Q5XKP0 4 +Exercise intolerance 0.542108114688915 2.1762156425195496 0.0295391397952868 1.0 0.4188955019598143 33 Q9H2D1,P00403,Q53H12,Q9Y2R0,P13473,P03886,P40939,P23786 8 +Limb ataxia 0.5561242459841478 2.172405957039173 0.0298250560888699 1.0 0.4188955019598143 25 Q9UBB4,P07196,Q9NR77,P04062,Q9NW15,O14773,Q12768,Q8IV08,Q10713,O75298,Q14108 11 +Postaxial foot polydactyly 0.7811912899906097 2.170406579918369 0.0299760587781079 1.0 0.4188955019598143 7 Q9UBM7,Q14739,Q96J42,Q10713 4 +Abnormality of the 5th toe 0.7811912899906097 2.170406579918369 0.0299760587781079 1.0 0.4188955019598143 7 Q9UBM7,Q14739,Q96J42,Q10713 4 +Distal muscle weakness 0.4242400488186708 2.1689304161775604 0.0300879671269937 1.0 0.4188955019598143 66 Q04656,P02545,O95831,P07196,Q9NR77,Q8TB36,Q9BQT8,O95140,Q8TD16,P39210,O15269,P53007,Q6UWE0,Q99720,P40939,Q96RL7 16 +Abnormal circulating copper concentration 0.7498319657643918 2.1681413040161868 0.0301479370601325 1.0 0.4188955019598143 8 P35670,Q9Y487,O43819 3 +Convex nasal ridge 0.5759516068338018 2.166277142354427 0.0302900153146561 1.0 0.4188955019598143 21 O75844,P02545,Q6NUK1,O96028,O95202 5 +Abnormality of the tarsal bones 0.5462978110957647 2.161243216703254 0.0306765566784781 1.0 0.4188955019598143 30 P16435,O75844,P02545,O43175,Q15125,O14656,O75787,Q9UHX1,P40939,Q14739,Q04656 11 +Infantile axial hypotonia 0.7021954316628367 2.1605771428400056 0.0307280186379055 1.0 0.4188955019598143 10 P07602,Q9NZJ7,P17900 3 +Diarrhea 0.4325367462788291 2.1579072833361455 0.0309350411201885 1.0 0.4188955019598143 74 Q9BT22,P54802,Q5HYI8,P03886,P40939,Q16836,P42892,P06280,P00403,P39210,Q13510,P50416,Q13423,Q04656,Q9UJS0,P04637,Q15904,P38398,Q96A33 19 +3 methylglutaconic aciduria 0.7016586380418705 2.157738675755184 0.0309481551502597 1.0 0.4188955019598143 10 Q53H12,Q5XKP0,Q9H6K4 3 +Abnormal exteroceptive sensation 0.4812052307910116 2.1566554745505617 0.0310325186828317 1.0 0.4188955019598143 52 P07602,O95831,P07196,Q9NR77,Q9NZ08,P04637,Q8NCH0,P06280,P54802,Q9NZJ7,P05067,P39210,O15269,O15460,Q9H6K4 15 +Oromandibular dystonia 0.8483975959829047 2.155173902720371 0.0311482283008026 1.0 0.4188955019598143 5 Q99720,Q15043 2 +Hyperextensibility of the finger joints 0.8482587064676598 2.1545810351239565 0.0311946344206688 1.0 0.4188955019598143 5 P48651,P51812,Q9Y263,Q5H8A4 4 +Abnormality of hand joint mobility 0.8482587064676598 2.1545810351239565 0.0311946344206688 1.0 0.4188955019598143 5 P48651,P51812,Q9Y263,Q5H8A4 4 +Inappropriate behavior 0.6062004202220563 2.147489132776163 0.0317543614289321 1.0 0.4220750248327939 17 P07602,O43175,P17900,Q9NZJ7,P35670 5 +Abnormality of the tongue 0.4455046709674016 2.140754349896495 0.0322938530618475 1.0 0.4226592989698258 87 P07196,Q9NQT5,Q7LGA3,Q10713,P40855,Q96RL7,O00754,P16278,Q6NUK1,Q9Y4P3,Q03252,Q99643,Q13510,O15460,P48651,Q9UBM7,O75844,P02545,O95831,P20700,Q96J42,Q9BQT8,O75431,P21912,O94905,P10253,Q96A33,O75381 28 +Shuffling gait 0.6829946154138531 2.139944402655882 0.0323592601169924 1.0 0.4226592989698258 11 O75844,P02545 2 +Sclerocornea 0.7129874550105768 2.1384885309729715 0.0324771139923021 1.0 0.4226592989698258 9 Q6NUK1,Q96J42,O96028,P53701,Q5H8A4,O95202 6 +Lower limb amyotrophy 0.5969058473845573 2.1383769611996537 0.0324861607959685 1.0 0.4226592989698258 18 P02545,Q9NVI7,O00400,P07196,Q9NR77,Q8TD16,O75298 7 +Prenatal movement abnormality 0.44003703642363 2.1375080010009104 0.0325566956560221 1.0 0.4226592989698258 61 Q4J6C6,Q9HC21,Q7KZN9,P51530,P56589,P53007,P40855,Q9UM00,O43175,O14656,O96028,Q9UBM7,O95202,O75844,P02545,Q70HW3,Q8TD16,P04062,Q96S52,Q969X5,Q5H8A4 21 +Axonal degeneration regeneration 0.8441865096603454 2.1371811975851003 0.0325832567233781 1.0 0.4226592989698258 5 Q6UWE0,Q8TB36,P02545 3 +Ankle clonus 0.6108859814958041 2.1289214574497883 0.033260759167895 1.0 0.4302168552928049 16 P07602,Q9NZJ7,Q15043,Q9NW15,O75787,O75298 6 +Ichthyosis 0.5287911568628747 2.1261279958170216 0.0334926034380731 1.0 0.4307867926415648 36 P02545,O43175,Q15125,P04062,P51648,Q15800,P40855,O95470,O75381 9 +Abnormal choroid morphology 0.5456622557561372 2.1175385890927547 0.0342141638455129 1.0 0.4327515521464081 27 P50148,Q8IY17,Q5XKP0,Q96J42,P04439,P53701,Q12768,P56589,Q10713,P40855,P40939,O75381,O43505,Q9Y619,Q01968 15 +Abnormal enchondral ossification 0.5420463686403143 2.115334927739537 0.0344014115910822 1.0 0.4327584166911141 29 P10644,Q9UG56,Q96HY6,P38435,O96028,O00116,O75381,Q9Y619,P40855,Q15125,Q9UBM7,Q14739,O95202 13 +Slurred speech 0.7082391958031865 2.11395351644468 0.0345192376857501 1.0 0.43288065490334 9 P16278,Q9NW15,Q9Y487,Q96RL7 4 +Abnormal activity of mitochondrial respiratory chain 0.4798958717410927 2.108053711137033 0.0350263437401863 1.0 0.4334234281729708 51 Q9P0J0,P21912,P20674,Q96CU9,Q70HW3,P13073,Q9UBX3,Q7KZN9,O75648,O95299,O96000,O75306,Q9Y2R0,Q86Y39,Q9Y6M9,P51970,P03886,O43676 18 +Coxa valga 0.5498271351315986 2.107897016858707 0.0350398983299566 1.0 0.4334234281729708 23 O75844,O00754,P16278,P02545,Q96L58,Q96A33,P51812,P55011,Q9Y619,Q04656 10 +Echolalia 0.7375872510438568 2.107815606986126 0.0350469423291976 1.0 0.4334234281729708 8 P53701,Q9UHX1,Q9UJS0 3 +Spastic gait 0.5478555722186415 2.102441265779512 0.0355146395814103 1.0 0.4334234281729708 24 Q9NVI7,O00400,P20700,Q15043,O75787,Q12768,O75298,Q15041,Q9Y619 9 +Abnormal saccadic eye movements 0.5448418444524906 2.1002760209580345 0.035704567373088 1.0 0.4334234281729708 26 O95140,P04062,Q9NW15,O14773,Q8IV08,O43819,Q10713,O75306,P51798,Q96RL7 10 +Muscle abnormality related to mitochondrial dysfunction 0.52548646479674 2.0996967973799525 0.0357555215014415 1.0 0.4334234281729708 36 O60313,Q96CU9,Q9UBX3,P51530,P00403,O75648,O96000,Q53H12,Q9Y2R0,Q86Y39,Q9Y6M9,P12235,P03886,O43676 14 +Wide cranial sutures 0.7661858664329043 2.099665665881323 0.0357582618856553 1.0 0.4334234281729708 7 O75844 1 +Delayed cranial suture closure 0.5398523683635159 2.0987685339500013 0.0358373099025943 1.0 0.4334234281729708 29 P16435,O75844,P02545,Q8NCH0,Q9Y487,P40855,P48651,O75431,O75381,Q04656 10 +Erlenmeyer flask deformity of the femurs 0.9428038545228428 2.08829139400405 0.0367715572969509 1.0 0.4340935660533765 4 P04062,P07602,Q9NZJ7 3 +Supernumerary spleens 0.7032826825961996 2.088268369918281 0.0367736329858332 1.0 0.4340935660533765 9 O96028,Q96J42,O95202 3 +Aplasia involving bones of the extremities 0.8321720155498018 2.0856524690462868 0.0370101148514179 1.0 0.4340935660533765 5 P02545,O75962,Q04656 3 +Hypothermia 0.6873553811104722 2.0817599943173883 0.0373643976068729 1.0 0.4351633354789609 10 P03886,Q5XKP0,Q04656 3 +Abnormality of alkaline phosphatase level 0.5634225770855785 2.07971944263559 0.0375512737048346 1.0 0.4351633354789609 21 Q8N511,Q9UJS0,P04637,Q96AY3,Q96A33,P51798,Q14739,Q92643 8 +Abnormal talus morphology 0.5632144435113879 2.0782741765944457 0.0376841134880285 1.0 0.4351633354789609 21 P16435,O75844,P02545,O43175,Q9Y263,O14656,Q96DX4,Q969X5,Q9UHX1,Q53GS7,Q99567 11 +Bird like facies 0.761640996197946 2.0781283102222416 0.0376975427947823 1.0 0.4351633354789609 7 O75844 1 +Peripheral axonal neuropathy 0.4524108754081936 2.0777897565266943 0.0377287277102309 1.0 0.4351633354789609 57 O60313,Q9NVI7,Q9HC21,P07602,O95831,P07196,Q9NZJ7,P00403,P39210,Q8IV08,O15269,P12235,P03886,Q9BPX6,Q96RL7,O76024 16 +Chronic diarrhea 0.5711890283391481 2.075445921837167 0.0379452259038408 1.0 0.4365607774213249 20 Q96A33,Q9BT22,Q13510,Q04656 4 +Confusion 0.5947254354105478 2.0741368139687664 0.0380666064282615 1.0 0.4368596261529062 17 Q9UJS0,Q9NZ08,P05067,O96008,P40939,Q16836,Q9Y619 7 +Retinopathy 0.5358512871618736 2.0684769574317623 0.0385951951975318 1.0 0.4369359907185103 29 Q5JRA6,O96028,P51648,O43819,Q5H8A4,P40939,O95202 7 +Abnormality of fontanelles 0.4964389080169979 2.067629163285595 0.0386749075745977 1.0 0.4369359907185103 45 P16435,O75844,P02545,P20674,Q6NUK1,Q16134,Q9BT22,Q8NCH0,P51812,Q9Y487,Q9Y619,O15228,P40855,P48651,Q15125,O75381,Q04656 17 +Neurofibrillary tangles 0.8278297889490204 2.0669586257612584 0.0387380527439709 1.0 0.4369359907185103 5 P61916,O15118,P05067 3 +Temperature instability 0.7292118674539623 2.0663135286242285 0.0387988848233866 1.0 0.4369359907185103 8 Q9HC21,P07602,P20700,Q9NZJ7 4 +Abnormal glycosylation 0.5415015471533703 2.065398276572881 0.0388853315156505 1.0 0.4369359907185103 25 Q8N511,Q9BT22,Q15904,Q96AA3,O75787,Q9Y487,P51571,P46977 8 +Hypersplenism 0.7588933844306744 2.065082839413688 0.0389151628361001 1.0 0.4369359907185103 7 P04062,Q14108,P07602 3 +Left ventricular systolic dysfunction 0.7569945863227442 2.0560564794315392 0.0397770725012329 1.0 0.4420200315478211 7 O75844,P02545 2 +Polyhydramnios 0.4779225333816085 2.055035459723415 0.0398755798637422 1.0 0.4420200315478211 50 O75844,P02545,Q9NVI7,P21964,O43175,Q15645,Q70HW3,O14656,P04062,P53007,Q9UM00,Q15125,P51798,Q9UBM7,Q14739 15 +Abnormal lung development 0.4849260229028364 2.05408415439978 0.0399675474171772 1.0 0.4420200315478211 48 O75844,Q5H8A4,P02545,Q6NUK1,O43175,Q16134,Q69YQ0,Q96L58,O96028,O96000,Q9UHX1,Q15645,P21964,Q9UBM7,O60566,Q14739,O95202 17 +Thoracic kyphoscoliosis 0.7859709685274459 2.053085117205116 0.0400643231107016 1.0 0.4420200315478211 6 O75844 1 +Cerebral inclusion bodies 0.621415493860973 2.051575321141165 0.040210952633404 1.0 0.4420200315478211 14 P61916,P04062,O15118,P05067 4 +Limited wrist movement 0.7848509958441131 2.047978315261592 0.0405621242181282 1.0 0.4420200315478211 6 O75844,P02545 2 +Abnormal pericardium morphology 0.6654665009787248 2.0439043107163224 0.0409630012132635 1.0 0.4420200315478211 11 Q9NZ08,P04062,P02545,Q14108 4 +Varicose veins 0.754429656662613 2.043849260750207 0.0409684409667114 1.0 0.4420200315478211 7 P04062 1 +Delayed menarche 0.7838181155481765 2.043266132016676 0.0410261003292911 1.0 0.4420200315478211 6 O75844,P02545 2 +Absence of subcutaneous fat 0.7516217687371316 2.03046697970986 0.0423090943172503 1.0 0.4493562265074212 7 O75844 1 +Abnormal protein glycosylation 0.564404846960661 2.0291553122171706 0.0424424735878794 1.0 0.4493562265074212 20 Q8N511,Q9BT22,Q15904,Q96AA3,O75787,Q9Y487,P51571 7 +Abnormal arterial physiology 0.5337067487910268 2.028286613489198 0.0425310044087436 1.0 0.4493562265074212 27 O75844,Q9NWM8,P02545,Q9NZ08,P04637,P06280,Q9Y4P3,P05067,Q14739 9 +Ventricular preexcitation 0.7804741804733846 2.0279940644459415 0.0425608537975179 1.0 0.4493562265074212 6 P03886,P13473,P00403 3 +Abnormal placental size 0.9271454449666112 2.026220465417652 0.0427421973357333 1.0 0.4493562265074212 4 O75844,P02545 2 +Submucous cleft of soft and hard palate 0.5796428544805305 2.025537428741707 0.0428122091854945 1.0 0.4493562265074212 18 O75844,P02545,O43175,Q15392,Q7LGA3 5 +Arteriosclerosis 0.6169748130435035 2.0248319889347086 0.0428846191272642 1.0 0.4493562265074212 14 O75844,P02545,P16278,P38435,Q13510,O15118 6 +Coronal craniosynostosis 0.749394008926949 2.0198356409510216 0.0434004388619058 1.0 0.4495876641651977 7 Q9NX62,Q6NUK1 2 +Phenotypic variability 0.4493048392701662 2.0180152112186844 0.0435896771497008 1.0 0.4495876641651977 101 O60313,Q15427,P07196,Q9NQT5,Q13509,Q9H061,P09622,Q6UWE0,P03886,P07602,P17900,O14656,P00403,Q13510,Q6P4A7,O95470,O14578,P02545,Q9NR77,Q70HW3,Q8TD16,Q15125,P21912,Q9UBB4,Q9Y263,O95140,O14979,Q9NZJ7,Q9UEY8,Q53H12 30 +Limb muscle weakness 0.4323341424038289 2.0178498600607813 0.0436069002966816 1.0 0.4495876641651977 85 O00400,P07196,O15269,O43819,P53007,P05023,P40939,Q96RL7,P50402,P39210,Q13510,Q12768,P35670,P02545,Q9NR77,Q8TB36,Q9BQT8,O75298,Q99720,Q14739,P12235,Q13126 22 +Parkinsonism 0.5273992901467228 2.0171332699701296 0.0436816075048283 1.0 0.4495876641651977 30 P07602,Q9NZJ7,Q15043,P05067,O75787,P04062,Q99720,Q96RL7 8 +Biliary cirrhosis 0.7485841563223996 2.0159678042247644 0.0438033425417168 1.0 0.4495876641651977 7 P09601 1 +Unexplained fevers 0.8149524570454905 2.0113013294484734 0.0442936381710463 1.0 0.4495876641651977 5 P07602 1 +Dystrophic toenail 0.9233823193134318 2.0112497553625626 0.04429908271136 1.0 0.4495876641651977 4 O75844 1 +Calcinosis 0.8142802044268539 2.0083868381840726 0.0446022004385924 1.0 0.4495876641651977 5 O75844,P02545,Q14739 3 +Prenatal maternal abnormality 0.6141389452775168 2.0077108138458617 0.0446740308353712 1.0 0.4495876641651977 14 P16435,P49366,P02545,Q8TAA9,P50416,P40939,Q14739 7 +Mitral stenosis 0.922075870884716 2.006047565641077 0.0448511733674492 1.0 0.450380532564803 4 O75844,P02545 2 +Abnormal circulating non proteinogenic amino acid concentration 0.7462262342863825 2.00469717705121 0.0449954305039654 1.0 0.4507182344135888 7 P03886,Q9UJS0,Q9Y619 3 +Cachexia 0.5685169832835801 2.0029738238028645 0.045180098186468 1.0 0.4507182344135888 19 Q99720,P04062,P02545,P07602 4 +Mitochondrial myopathy 0.5271257835546799 2.0020570712689976 0.0452785938246584 1.0 0.4507188720067634 29 O60313,Q96CU9,P00403,O96000,Q53H12,Q86Y39,Q9Y6M9,P12235,P03886,O43676 10 +Abnormal visual electrophysiology 0.4824386417285568 2.0009863517896447 0.0453938607261936 1.0 0.4508860916816503 47 O60313,P50897,P07602,O43681,O95140,Q9NZJ7,O75503,Q53H12,Q96S66,P12235,P40939,P51798 12 +Hemivertebrae 0.6425481964790717 1.9996687421358923 0.0455360456118665 1.0 0.4513193784777853 12 Q15125,Q12768,Q9UHX1,Q9Y619 4 +Stroke like episode 0.7737374694561356 1.9971507927799077 0.045808804644335 1.0 0.45304215219527 6 P03886,Q96AA3,O76024,P00403 4 +Hammertoe 0.5590350581435936 1.992341351293187 0.0463336175420892 1.0 0.4530778196169427 20 P07196,Q9NR77,Q8TB36,O14656,P39210,Q6UWE0,Q99720,Q9UBM7 8 +Abnormality of prothrombin 0.6265559148750837 1.992001582248086 0.046370884280336 1.0 0.4530778196169427 13 P40939,P38435,Q5XKP0,Q9UJS0 4 +Upper airway obstruction 0.8103125006400395 1.9911672485508296 0.0464625032122412 1.0 0.4530778196169427 5 P16435,P02545,O75844 3 +Erythema 0.5505638516206784 1.9899766939607344 0.0465935029020825 1.0 0.4530778196169427 21 P22830,P98194,P00403,P51648,P03886,Q15125,Q06136 7 +Abnormality of the larynx 0.4871562646767718 1.9858833908539515 0.0470462733728636 1.0 0.4530778196169427 45 P16435,P02545,Q15165,P07602,P04637,Q9NZJ7,Q13510,Q9UHX1,P21964,Q9UBM7,Q14739 11 +Chronic pulmonary obstruction 0.6822614823229134 1.9784958211058563 0.0478727995541647 1.0 0.4530778196169427 9 P09601,P21964 2 +Paresthesia 0.5295851482955333 1.97721581133304 0.0480172411179899 1.0 0.4530778196169427 25 P07196,Q9NR77,Q9NZ08,P04637,P06280,P54802,P05067,O15460,Q9H6K4 9 +Preaxial hand polydactyly 0.6677946658487838 1.976776895836602 0.0480668543852564 1.0 0.4530778196169427 10 Q5H8A4,Q9UHX1,Q96J42,O95202 4 +Microcytic anemia 0.7110915381725075 1.975860577159716 0.0481705702488743 1.0 0.4530778196169427 8 Q9UBX3,P22830 2 +Tissue ischemia 0.5562553208904812 1.9732236938365948 0.0484700821352193 1.0 0.4530778196169427 20 O75844,P02545,Q9NZ08,P04637,P06280,Q9Y4P3,P05067 7 +Tetraplegia tetraparesis 0.4916614443263308 1.9727132082987244 0.0485282462588481 1.0 0.4530778196169427 43 Q9H9P8,P07602,O95831,P17900,O43681,P20700,Q9UBX3,P51572,Q9Y296,O94905,Q9NZJ7,Q13423,P21912 13 +Arthralgia 0.5156983597359532 1.9694742488070105 0.0488986568432046 1.0 0.4530778196169427 33 P02545,Q96HY6,Q9NZ08,P06280,Q9Y4P3,Q03252,Q13510,Q15800,O15460,P35670 10 +Aplasia hypoplasia of the nipples 0.5709751183224587 1.9683272836463772 0.0490303926474213 1.0 0.4530778196169427 18 Q6NUK1,Q96A33,Q12768,Q5H8A4,O95202 5 +Stillbirth 0.6518035932474959 1.9683087103219163 0.0490325283531867 1.0 0.4530778196169427 11 O75844,P02545,O43175,P04062,Q14739 5 +Abnormality of the vasculature of the eye 0.4155442732484445 1.966280476330538 0.0492662207879122 1.0 0.4530778196169427 74 P16278,P07602,P38435,P17900,Q9Y4P3,P06280,Q9NZJ7,Q9NW15,Q13510,P10619,P03886,P21964,Q96S66,Q14739 14 +Metatarsus adductus 0.6219744595203198 1.9650545145314091 0.049407928338707 1.0 0.4530778196169427 13 Q15392,Q96L58,O96028,Q03252,Q9UBM7,O95202 6 +Accessory spleen 0.7379527394833496 1.9650421396216968 0.0494093604820966 1.0 0.4530778196169427 7 O96028,Q96J42,O95202 3 +Foot dorsiflexor weakness 0.5149052370728622 1.9631917515455757 0.0496238974427021 1.0 0.4530778196169427 33 P02545,Q6UWE0,P07196,Q9NR77,Q8TB36,Q9BQT8,P39210,O15269,O43819,P05023,Q99720,Q14739 12 +Abnormal speech prosody 0.7375425120601931 1.963071527417724 0.0496378634100289 1.0 0.4530778196169427 7 P03886 1 +Focal t2 hyperintense brainstem lesion 0.5701674952959321 1.9629778538801752 0.0496487473838205 1.0 0.4530778196169427 18 Q86Y39,P03886,O43676,Q9Y6M9 4 +Generalized myoclonic seizure 0.5013457359841446 1.9626841645755304 0.0496828842627639 1.0 0.4530778196169427 39 P16278,P07602,O43175,Q01105,P52788,Q9NZJ7,Q96N66,P04062,Q13510,P03886,P21912,Q9Y619 12 +Respiratory arrest 0.7374350211545576 1.9625551043467684 0.0496978917604142 1.0 0.4530778196169427 7 P23786,P13473,P53007 3 +Decerebrate rigidity 0.9107864470003032 1.960991917446566 0.0498799657579822 1.0 0.4530778196169427 4 P07602,Q9NZJ7,O43681 3 +Abnormality of the temporomandibular joint 0.9107308062641056 1.9607694084978056 0.049905928161837 1.0 0.4530778196169427 4 O75844,P02545 2 +Cognitive impairment 0.4987360348579794 1.9587307429062704 0.0501443281083131 1.0 0.4530778196169427 161 O60313,O43681,P07196,P54802,P06865,Q9Y2R0,O43819,Q10713,P40855,P03886,Q96RL7,P10644,P16278,P50897,P07602,P17900,P06280,P00403,P05067,Q13510,O96008,O95470,P35670,O15118,O76024,O95831,P20700,Q9NZ08,P04062,P61916,O75503,Q99720,Q14108,P21912,Q9H6K4,Q9UBB4,Q13144,Q5XKP0,Q9UJS0,Q9Y263,P04637,Q9NZJ7,Q9Y487,P13473,Q9Y619,P12235,O75381,P21964 48 +Optic neuropathy 0.5373284248413466 1.954965013700412 0.050587199896646 1.0 0.4544332917305776 22 Q96CU9,Q86Y39,Q9Y6M9,P03886,O43676 5 +Abnormal macular morphology 0.5237454911061298 1.953230115925754 0.0507923340405329 1.0 0.4544332917305776 27 P04062,Q13510,P50897,P51648 4 +Glomerulopathy 0.6633439502526679 1.952716763599265 0.0508531661919713 1.0 0.4544332917305776 10 Q9NZ08,P02545,Q14108,P06280 4 +Gastrointestinal obstruction 0.5758674674330528 1.9522343559048665 0.0509103870146188 1.0 0.4544332917305776 17 P42892,P04637,Q5HYI8,P38398,P21912,Q04656 6 +Hyperlipidemia 0.5168578119647409 1.9491029084018248 0.0512831364261439 1.0 0.4544332917305776 31 O75844,P02545,P22830,Q9UJS0,P50402,P06280,P50416,O95470,O75431,P23786 10 +Emg abnormality 0.4173962461862474 1.9488898100129264 0.0513085852423473 1.0 0.4544332917305776 77 O60313,O43681,P07196,Q9NW15,O15269,O43819,Q96RL7,P07602,P50402,P39210,Q13510,Q04656,P02545,Q9NR77,Q8TB36,Q9NZJ7,P13473,P12235,P42167 19 +Abnormal middle phalanx morphology of the hand 0.705234532957728 1.9464310912856528 0.051602977882226 1.0 0.4559414529512905 8 P48651,P02545,Q9UHX1,Q15233 4 +Steppage gait 0.5360043611668495 1.9454353505716595 0.0517226035711395 1.0 0.4559414529512905 22 P02545,Q6UWE0,P07196,Q9NR77,Q8TB36,O15269,O43819,P05023 8 +Progeroid facial appearance 0.7337800152212088 1.9449783534469076 0.0517775836502885 1.0 0.4559414529512905 7 O75844,P02545,O75431 3 +Abnormal circulating ceruloplasmin concentration 0.7971600859076705 1.9338683578263416 0.0531293154462451 1.0 0.4653119532413173 5 Q8N511 1 +Abnormal large intestine physiology 0.5342652021674203 1.932902658519404 0.0532481903250601 1.0 0.4653119532413173 22 P07602,P20700,O43681,Q9NZJ7,P06280,P21964 6 +Fasting hyperinsulinemia 0.902593432355886 1.9281810022314751 0.0538326163587297 1.0 0.4686303237768505 4 P02545,P40939 2 +Increased csf lactate 0.4671954462292978 1.9227224968811556 0.0545149099660207 1.0 0.4734958789070025 49 Q9P0J0,Q9HC21,O95831,Q96CU9,P13073,Q7KZN9,P00403,O95299,O96000,P39210,O43819,Q86Y39,Q9Y6M9,P03886,O43676 15 +Episodic vomiting 0.6146928353591071 1.9220589107584705 0.0545983455040177 1.0 0.4734958789070025 13 Q9Y289,P00403,P03886,P22695,Q9Y619,Q2TAA5 6 +Peroneal muscle atrophy 0.8992850481815297 1.9149052796870552 0.0555045843852639 1.0 0.4743507376923019 4 P02545,Q12768,Q96RL7 3 +Impaired temperature sensation 0.7921774638019083 1.9120746718488952 0.0558666170144241 1.0 0.4743507376923019 5 O15269,Q9NR77 2 +Osteolysis involving bones of the feet 0.7919290682729743 1.9109869685328928 0.056006255584575 1.0 0.4743507376923019 5 O75844,P02545 2 +Foot acroosteolysis 0.7919290682729743 1.9109869685328928 0.056006255584575 1.0 0.4743507376923019 5 O75844,P02545 2 +Abnormal mitochondria in muscle tissue 0.5390380941024611 1.9087549188460269 0.0562937148804298 1.0 0.4743507376923019 21 Q96CU9,Q86Y39,Q9Y6M9,P03886,O43676 5 +Joint dislocation 0.4310525017485021 1.9064083758041948 0.0565972428795167 1.0 0.4743507376923019 93 Q9BXW9,Q9NQT5,Q9NX62,Q9UHX1,P55011,P53007,Q96PU5,P10644,Q9Y4P3,O14656,O96028,P51798,Q9UBM7,Q04656,O95202,O75844,P02545,P57678,Q8TD16,P51571,Q15125,Q8NCH0,P38398,Q96A33,Q9Y487,P21964,Q9Y619 27 +Widely patent fontanelles and sutures 0.8970197474438795 1.9058064912980093 0.056675316441898 1.0 0.4743507376923019 4 O75844 1 +Bruising susceptibility 0.5128431007063513 1.9045350334046376 0.0568405385165942 1.0 0.4743507376923019 30 P10644,Q9NWM8,P38435,Q9BXW9,Q8NCH0,P04062,Q13126,Q14108,P51798,P35670,Q04656 11 +Abnormality of the achilles tendon 0.5971477470569164 1.9044354824659568 0.0568534917580112 1.0 0.4743507376923019 14 O60313,P02545,P50402,Q8TD16,Q8WXH0,Q15041 6 +Lower extremity joint dislocation 0.4168011278884448 1.904046861537346 0.0569040813485846 1.0 0.4743507376923019 80 Q9BXW9,Q9NQT5,Q9NX62,Q9UHX1,P55011,P53007,Q96PU5,Q9Y4P3,O14656,O96028,Q9UBM7,Q04656,O95202,O75844,P02545,P57678,Q8TD16,Q15125,P38398,Q96A33,Q9Y487,P21964 22 +Bicornuate uterus 0.7252717897194236 1.9039364411362416 0.056918462399824 1.0 0.4743507376923019 7 Q69YQ0,P38398,Q9UBM7,Q9BXW9 4 +Areflexia 0.4243691509071189 1.9031857329363409 0.057016314125581 1.0 0.4743507376923019 87 O60313,P07196,Q9BT22,O75787,O15269,O43819,P53007,P05023,Q6UWE0,P40939,Q96RL7,P39210,Q13510,P02545,O95831,Q9NR77,Q8TB36,Q9BQT8,Q8TD16,Q15041,Q9H6K4,P10253,P12235 23 +Resting tremor 0.5381903527992494 1.9027517628427064 0.0570729441472774 1.0 0.4743507376923019 21 P07602,Q9NZJ7,P04062,O75787,P12235,Q9H6K4,Q96RL7 7 +Photophobia 0.4962961110225342 1.9001398753602576 0.0574147659995709 1.0 0.4743507376923019 38 Q8WWV3,P07602,Q9NZ08,Q9NZJ7,Q6P4Q7,P51648,Q96S66,P40939 8 +Generalized hyperkeratosis 0.7526087216619197 1.8997621228079864 0.0574643436988369 1.0 0.4743507376923019 6 O75844,P02545,P21912 3 +Fasciculations 0.4985404310654692 1.8995208010450333 0.0574960343262116 1.0 0.4743507376923019 37 P07602,O95831,P07196,Q9BQT8,Q8TD16,P06280,Q9NZJ7,Q9NW15,Q13510,O43819,Q6UWE0 11 +Corneal dystrophy 0.789104950346718 1.8986121701103449 0.0576154870860416 1.0 0.4743507376923019 5 P12235,Q53H12,P06280 3 +Progressive gait ataxia 0.6391148875337626 1.8975311304485205 0.0577578741691275 1.0 0.4743507376923019 11 P07602,Q9NZJ7,O43681 3 +Dysostosis multiplex 0.6955377352751656 1.897503074698079 0.0577615733695267 1.0 0.4743507376923019 8 O00754,P16278,Q9Y223,P15586,P54802,P10619 6 +Retinal degeneration 0.434649152169418 1.8968649759261655 0.0578457610135385 1.0 0.4743507376923019 57 O60313,Q9UG56,O00754,P50897,P02545,P04439,Q9Y296,P04062,Q9NW15,Q7LGA3,O14773,P55011,Q10713,Q13510,P51648,O75503,Q96S66 17 +Spastic tetraparesis 0.5292516562143021 1.8966759204594197 0.057870723646658 1.0 0.4743507376923019 22 Q9H9P8,P20700,P07602,P17900,Q9Y296,Q9NZJ7,P21912 7 +Hypolipoproteinemia 0.6952997442052071 1.896299027524196 0.0579205148061925 1.0 0.4743507376923019 8 P02545,Q9UJS0,Q15800 3 +Poor eye contact 0.4955778886769394 1.8941522816659144 0.0582047998540351 1.0 0.4743507376923019 38 Q9P0J0,Q5XKP0,Q96CU9,Q5KU26,O96000,Q9UHX1,Q86Y39,P53007,Q9Y6M9,P03886,O43676 11 +Transient ischemic attack 0.7227345463133188 1.8916633134016845 0.0585358543164991 1.0 0.4743507376923019 7 O75844,P02545,P06280 3 +Cardiac valve calcification 0.8930680758470494 1.8899174411802833 0.058769002538928 1.0 0.4743507376923019 4 O75844,P04062,P02545 3 +Mitral valve calcification 0.8930680758470494 1.8899174411802833 0.058769002538928 1.0 0.4743507376923019 4 O75844,P04062,P02545 3 +Bone pain 0.5282446945141286 1.889382273776318 0.0588406243741488 1.0 0.4743507376923019 22 P07602,Q9NZJ7,P04062,Q14108,P35670 5 +Parkinsonism with favorable response to dopaminergic medication 0.651072647076832 1.8860497435068448 0.059288251735708 1.0 0.4762822889435214 10 P04062,P07602 2 +Abnormal sharpey fiber morphology 0.7494739046809035 1.8852294570737795 0.0593988654362143 1.0 0.4763352098641424 6 P02545,P35670 2 +High frequency sensorineural hearing impairment 0.8912029841467071 1.8824108331913885 0.059780256163791 1.0 0.478555582122376 4 O75844,P02545,Q13510 3 +Dilated cardiomyopathy 0.4939151733628925 1.8802762122214256 0.0600704435235626 1.0 0.4797145627930521 38 P16278,P02545,P00403,P53701,O43819,P13473,P03886,P40939,P23786,Q16836,Q96RL7,P42167 12 +Joint swelling 0.7202862476664735 1.8798057104634769 0.0601345619225184 1.0 0.4797145627930521 7 P14174,P04637,Q9UBC1,Q13510,P35670,Q01968 6 +Acquired abnormal hair pattern 0.784102803267989 1.876656698811874 0.0605651609747641 1.0 0.4823093427886001 5 O75844 1 +Dystrophic fingernails 0.6912445586182745 1.875759598382378 0.060688298034373 1.0 0.4824508970475592 8 O75844 1 +Posterior embryotoxon 0.5418982392435535 1.873827379460415 0.0609542213679268 1.0 0.482827004342483 20 Q9Y4P3,Q7LGA3,P40855,O75381,P21964 5 +Generalized hyperpigmentation 0.6624121166424295 1.873606499129998 0.0609846816050352 1.0 0.482827004342483 9 P51648 1 +Abnormal aortic valve physiology 0.4906775009013283 1.8731190994039064 0.0610519404923122 1.0 0.482827004342483 39 O75844,Q96PU5,P16278,P02545,Q9NZ08,Q9Y4P3,P04062,Q12768,Q9UHX1,Q15125 10 +Aplasia hypoplasia of toe 0.4928078901820747 1.8710242068100649 0.0613417258582063 1.0 0.484282349490908 38 P10644,P02545,Q5JRA6,Q69YQ0,Q9NX62,P13073,Q9Y296,O96028,Q7LGA3,Q13510,Q9UHX1,P55011,Q5H8A4,Q9UBM7,O95202 15 +Abnormal circulating fatty acid concentration 0.5560942433838758 1.8692475003271136 0.0615883884948194 1.0 0.4853928242991016 18 O75880,O75381,P40855,P40939,O75431,P23786,Q16836 7 +Abnormal circulating acetylcarnitine concentration 0.7456237852501869 1.8673516389963185 0.0618524985578592 1.0 0.4859965623638445 6 P40939,Q16836 2 +Venous insufficiency 0.66038233558397 1.86281371258185 0.062488480092953 1.0 0.4875730164511436 9 P04062,P21964 2 +Abnormal csf metabolite level 0.4429384323418808 1.861694849120971 0.0626461150489443 1.0 0.4878512938930547 54 Q9P0J0,Q9HC21,O95831,Q96CU9,P13073,Q7KZN9,P00403,O95299,O96000,P39210,O43819,Q86Y39,Q9Y6M9,P03886,O43676 15 +Chondrocalcinosis 0.7795373392142715 1.8565770245914897 0.0633713552004036 1.0 0.4909939686339223 5 P02545,P35670 2 +Abnormality of metacarpal epiphyses 0.7792852754309891 1.855467276035495 0.0635295280475083 1.0 0.4913880218404403 5 P16435,O96028,O95202 3 +Capillary hemangioma 0.7150317892323548 1.8543087512215748 0.0636950008382561 1.0 0.4918371143986089 7 P16435,Q7LGA3,Q9UBM7,Q9UHX1 4 +Somatic sensory dysfunction 0.4385580283531345 1.8513060994520216 0.0641255291058784 1.0 0.4938933657138317 105 O00400,P07196,P54802,O15269,O43819,Q6UWE0,Q96RL7,P07602,P06280,P05067,P39210,Q12768,O15460,Q04656,P02545,O95831,P20700,Q9NR77,Q9NZ08,Q8TB36,O75298,Q9H6K4,O95140,O00165,P04637,Q8NCH0,Q9NZJ7,Q8IV08,Q9Y619 29 +Abnormal aortic valve morphology 0.4879822409953328 1.850356711118832 0.0642621538686956 1.0 0.4938933657138317 39 O75844,P02545,Q6NUK1,Q9BXW9,P37268,P06280,Q9Y4P3,P38398,P04062,P51812,Q9UHX1,P21964 12 +Ascending tubular aorta aneurysm 0.7780890210775879 1.850198981404871 0.0642848757295138 1.0 0.4938933657138317 5 O75844 1 +Abnormal metabolic brain imaging by mrs 0.5669122661281177 1.8491402200221816 0.0644375680533697 1.0 0.4942372263255947 16 P07602,Q9NZJ7,P00403,O43819,P03886 5 +Paroxysmal involuntary eye movements 0.5452446657885472 1.845066174523788 0.065027912969277 1.0 0.49592560705319 19 P03886,O43676,Q86Y39,Q9Y6M9 4 +Abnormality of the spleen 0.4591148964298027 1.8436616830773431 0.0652324604749821 1.0 0.49592560705319 127 Q15392,Q9BT22,P54802,Q5HYI8,Q10713,P10619,Q96RL7,P16278,P07602,O96028,Q13510,P51798,P35670,O15118,O95202,P02545,Q96J42,Q9NZ08,P04062,P61916,Q14108,Q14739,Q9UJS0,P04637,Q15904,Q9NZJ7,P10253,Q96A33,P21964 29 +Abnormality of the biliary system 0.4587975655373641 1.8400900963725684 0.0657550110396136 1.0 0.4972707100472356 127 O43681,Q5HYI8,O75787,Q10713,P40855,P40939,P10644,P22830,P07602,P09601,Q9Y4P3,O96028,P39210,Q13510,P35670,O15118,O95202,Q04656,P02545,P04062,P61916,Q14108,Q14739,Q5XKP0,Q9UJS0,P04637,Q15904,Q9NZJ7,Q96A33,Q5H8A4,O75381,P21964 32 +Hypopigmentation of the skin 0.4407202264167903 1.839646460964088 0.0658201585506021 1.0 0.4972707100472356 54 P02545,P21964,P07602,Q9BXW9,Q8IZA0,P52788,Q9NP58,Q9NZJ7,P38398,P53701,Q99828,Q15125,P51798,P21912,Q04656,O00203 16 +Dental crowding 0.5086482871772027 1.838276050899618 0.0660217382582233 1.0 0.4972707100472356 27 O75844,P02545,Q01105,Q92643,Q69YQ0,P52788,Q15233,Q96A33,P51812,O75962,O75431,Q9UBM7,Q01968 13 +Hypoglycemic seizures 0.7117264310171125 1.8382359390215357 0.0660276461473508 1.0 0.4972707100472356 7 Q13423,P40939,Q16836,P31751 4 +Abnormality of the peripheral nervous system 0.4320559402149823 1.835162186940107 0.0664816620060191 1.0 0.4981190492495067 100 O60313,O43681,P07196,O15269,Q10713,Q6UWE0,Q96RL7,P07602,P42892,P06280,P39210,Q9UBM7,Q04656,O76024,P02545,O95831,P20700,Q9NR77,Q8TB36,P04062,Q99720,Q15125,Q9UBB4,O95140,Q9NZJ7,P38398,P21964,Q9Y619 28 +Ulnar claw 0.8793907367112198 1.8347610076246763 0.0665411084097802 1.0 0.4981190492495067 4 Q8TB36,P39210,Q9NR77 3 +Abnormality of the autonomic nervous system 0.4363160365173815 1.8333974150894508 0.066743491749353 1.0 0.4985619065583808 55 Q04656,P07602,P20700,O43681,P42892,P06280,Q9NZJ7,P38398,P04062,O15269,Q10713,P21964,Q9UBM7,Q96RL7,O76024 15 +Hip dislocation 0.411398697236992 1.829141974792928 0.0673783422813307 1.0 0.5005264336254257 61 Q15427,Q9BXW9,Q9NQT5,Q9UHX1,P55011,P53007,O14656,Q96L58,O96028,Q9UBM7,Q04656,O95202,O75844,Q01968,P02545,P57678,Q8TD16,P38398,Q96A33,Q969X5,Q9Y487 21 +Increased connective tissue 0.6810646239325644 1.824005071138334 0.0681513055842459 1.0 0.5016949927086642 8 P02545,O75431,O95831,P07196 4 +Zonular cataract 0.6111663997120972 1.8190527198807984 0.0689033873144444 1.0 0.5045285696322963 12 P08670,Q8WWV3,Q9H6K4,O76024 4 +Weak cry 0.6249479898347721 1.817864278178755 0.069084879275433 1.0 0.5045285696322963 11 O60313,Q13510,O75208,P53007 4 +Disproportionate short limb short stature 0.5262622461905578 1.817863002374507 0.0690850743197075 1.0 0.5045285696322963 21 P10644,Q15392,Q7LGA3,O00116,Q15125,Q14739 6 +Achilles tendon contracture 0.610838076391559 1.8171443853166285 0.0691950080212016 1.0 0.5045285696322963 12 O60313,P02545,P50402,Q8TD16,Q8WXH0 5 +Autoamputation 0.7345100430724363 1.8155675451608269 0.0694367358965635 1.0 0.5052485088241053 6 O15269 1 +Bilateral sensorineural hearing impairment 0.5065758446317513 1.8130077074308215 0.0698306325706246 1.0 0.5052485088241053 26 P03886,P07602,Q9NZJ7,O43681 4 +Abnormality of subcutaneous fat tissue 0.5822607355283946 1.812980604013122 0.0698348129189621 1.0 0.5052485088241053 14 O75844,P02545,Q6NUK1,O43175,Q9Y487 5 +Abnormality of the metacarpal bones 0.4809125420316506 1.8108192205971425 0.0701688400471023 1.0 0.5052485088241053 40 P16435,P10644,P16278,Q6NUK1,Q9BXW9,Q9NX62,Q96L58,O96028,Q15233,P51812,Q96S52,O75962,P48651,P51798,Q9UBM7,Q14739,O95202 17 +Elevated serum acid phosphatase 0.8731352041147985 1.8094525453545431 0.0703807261979649 1.0 0.5052485088241053 4 P07602,Q9NZJ7 2 +Abnormal brainstem mri signal intensity 0.5249997160291895 1.8088320425805335 0.0704771006204167 1.0 0.5052485088241053 21 P03886,O43676,Q86Y39,Q9Y6M9 4 +Postural tremor 0.5536997649241022 1.8067919773339916 0.0707947200738738 1.0 0.5052485088241053 17 P20700,Q9NR77,O95140,O14773,P03886,Q14108,Q9H6K4 7 +Adipose tissue loss 0.6365083769614535 1.8063044393829089 0.070870798793668 1.0 0.5052485088241053 10 O75844,P02545,O75431 3 +Slow pupillary light response 0.8720602568161857 1.8050984951591709 0.0710592705227184 1.0 0.5052485088241053 4 P07602,Q9NZJ7 2 +Abnormal pupillary light reflex 0.8720602568161857 1.8050984951591709 0.0710592705227184 1.0 0.5052485088241053 4 P07602,Q9NZJ7 2 +Abnormal circulating long chain fatty acid concentration 0.7677920539269487 1.8047424526950375 0.0711149933398134 1.0 0.5052485088241053 5 P40855,P23786,O75381 3 +Vascular skin abnormality 0.447104926044468 1.8036077920971296 0.071292813674473 1.0 0.5052485088241053 118 P38435,P10619,P03886,P10644,P16278,P22830,P98194,Q6NUK1,Q8IZA0,P06280,P00403,P51648,P48651,P51798,Q9UBM7,P35670,Q04656,O75844,P02545,P04062,P51812,Q15125,Q14108,Q99828,Q14739,Q9NWM8,Q8NCH0,P53701,Q9Y487,Q13126,Q06136,P21964 32 +Punctate cataract 0.8704485838331799 1.798567698869746 0.0720870907383486 1.0 0.5077578075143351 4 Q8WWV3,Q9H6K4 2 +Decreased ldl cholesterol concentration 0.8702430135613943 1.7977344537087845 0.0722190987975301 1.0 0.5077578075143351 4 Q15800 1 +Slowly progressive 0.4327353996872508 1.797229382607752 0.0722992117273086 1.0 0.5077578075143351 55 Q9P0J0,P02545,O95831,Q6UWE0,P12235,P07196,P50402,Q9NR77,O95140,O14979,P51530,O94905,O00584,O75787,Q8IV08,P05023,Q99720,Q04656 18 +Fetal distress 0.5073826550530232 1.7957879810763988 0.0725282429466149 1.0 0.5085862549043644 23 Q96CU9,Q86Y39,Q9Y6M9,P03886,O43676 5 +Spastic paraparesis 0.5303689386634759 1.793217297815659 0.0729381852391897 1.0 0.5106788229514522 20 Q5XKP0,P04062,O75787,Q9Y619,Q9H6K4 5 +Aplasia hypoplasia of the skin 0.4282386460274666 1.790290516387619 0.0734072200616382 1.0 0.5131781078812848 56 O75844,Q96PU5,P10644,P02545,Q9NWM8,Q15392,P04637,Q8NCH0,O96028,P53701,Q13126,Q5H8A4,Q15125,O75431,Q9Y619,O95202 16 +Weight loss 0.4011317258353201 1.7878548460870023 0.0737994294836967 1.0 0.5139784516936304 75 Q5HYI8,Q96RL7,P10644,P07602,P42892,O15460,Q13423,P35670,Q04656,O75844,P02545,Q9NZ08,P04062,Q15645,Q99720,P21912,P04637,Q9NZJ7,P38398,Q06136 20 +Impaired glucose tolerance 0.7285851782237139 1.787854204825071 0.0737995329695322 1.0 0.5139784516936304 6 P02545 1 +Loss of subcutaneous adipose tissue in limbs 0.8669567920422585 1.784407078381492 0.0743575417207231 1.0 0.514346344075713 4 O75844,P02545,O75431 3 +Abnormality of the amniotic fluid 0.4180501354723748 1.7822165061249524 0.0747139321003731 1.0 0.514346344075713 91 Q9NVI7,Q9BXW9,Q9BT22,Q7LGA3,Q9UHX1,P53007,Q9UM00,P40939,O60566,Q6NUK1,O43175,O14656,P51798,Q9UBM7,O75844,P16435,P02545,Q96J42,Q70HW3,P04062,Q15645,Q15125,P23786,Q14739,P38398,P21964 26 +Ankyloglossia 0.6728389263334293 1.781986190671511 0.0747514836989819 1.0 0.514346344075713 8 O75844 1 +Abnormality of the gastric mucosa 0.5628628767290532 1.781540433837159 0.0748242055572869 1.0 0.514346344075713 15 P04062,Q9Y4P3,O76024 3 +Biliary tract neoplasm 0.8658087113159341 1.7797478165153593 0.0751172411884129 1.0 0.514346344075713 4 P07602,Q9NZJ7 2 +Neoplasm of the gallbladder 0.8658087113159341 1.7797478165153593 0.0751172411884129 1.0 0.514346344075713 4 P07602,Q9NZJ7 2 +Abnormal retinal vascular morphology 0.4451286139154465 1.777958507060678 0.0754106698930399 1.0 0.514346344075713 51 P07602,P38435,P17900,Q9Y4P3,Q9NZJ7,Q13510,P10619,P03886,Q96S66,P21964 10 +Premature loss of teeth 0.5902526043320645 1.7762654591965394 0.0756891735132776 1.0 0.514978789773103 13 O75844,P02545,P51798 3 +Hyperactive patellar reflex 0.6988793922529526 1.7755208404198484 0.0758119275725575 1.0 0.5150486889536213 7 Q15041,P13073,P21912 3 +Talipes calcaneovalgus 0.7250801891656679 1.7714253453514948 0.0764899969611698 1.0 0.5181178936171551 6 Q9UBM7,Q9NR77,P07196 3 +Insidious onset 0.7596887939107899 1.768835197472114 0.0769213810730939 1.0 0.5189163629072931 5 P04062,Q12768,Q9NR77 3 +Abnormal motor nerve conduction velocity 0.5184927946828513 1.7621491501861124 0.0780441008826631 1.0 0.5239949513480091 21 P02545,Q9NR77,P07196,Q8TB36,Q6UWE0,Q99720 6 +Very long chain fatty acid accumulation 0.7231033876276929 1.76214835003357 0.0780442360382926 1.0 0.5239949513480091 6 P40855,O75381,P56589,Q5T8D3 4 +Abnormality of the mitochondrion 0.4138946848827538 1.7588303072604268 0.0786063353998198 1.0 0.525457532548577 89 Q9P0J0,P20674,P51530,Q7KZN9,P09622,Q9Y2R0,P03886,P40939,Q16836,O43676,Q96CU9,P00403,Q86Y39,Q16134,Q70HW3,P13073,O75648,O95299,O96000,Q9Y6M9,P23786,P21912,P12235,Q9UBX3,O75880,Q9P0J1,P51970,O75306,Q3ZCQ8 29 +Microglossia 0.86025483078262 1.7571854951651322 0.0788861967832881 1.0 0.5265596138056506 4 P48651,Q03252 2 +Paralysis 0.4357035779235811 1.7536526791072715 0.0794900385729973 1.0 0.5290478003281317 53 P02545,Q9HC21,Q15165,P20700,P17900,P50402,Q9NR77,Q8TB36,O95140,Q9NP58,Q99643,P04062,P10253,Q8WXH0,P51798,P21912 16 +Exaggerated startle response 0.6396365606117869 1.7518053369834206 0.0798072862072121 1.0 0.529619657308441 9 P16278,P06865,P17900 3 +Abnormal anatomic location of the heart 0.6126924461466735 1.7484066337758375 0.0803936400229496 1.0 0.5312012664719865 11 O75844,P02545,Q96J42 3 +Hypomimic face 0.5852314858216257 1.7460343202053916 0.0808049883551449 1.0 0.5331499159628368 13 P12235,P04062,O75787,Q15043 4 +Insulin resistance 0.5377066302040145 1.745330819169831 0.0809273002406398 1.0 0.5331886443192662 18 O75844,P02545,O95140,Q03252,P31751,O75431,O76024 7 +Generalized onset motor seizure 0.4347780676424296 1.744473704361393 0.0810765227634451 1.0 0.5332428636412965 53 P16278,P07602,O43175,Q01105,Q9Y320,P52788,Q9NZJ7,Q96N66,P04062,Q13510,P03886,P21912,Q9Y619 13 +Psychosis 0.4937735685657171 1.7436253218896849 0.0812244448833694 1.0 0.5332428636412965 29 P10644,Q9UJS0,P00403,P61916,P51812,O15118,P03886,Q96RL7,O76024 9 +Proportionate short stature 0.4873937028978544 1.742612382358386 0.0814013456399358 1.0 0.5332428636412965 33 P21912,P10644,P16278,Q5JRA6,Q96HY6,Q15392,P53701,Q9Y619,P10619,P48651,P40939,Q16836,Q14739 13 +Hyperconvex fingernails 0.7187760770691433 1.7418126765451931 0.0815412278034812 1.0 0.5332981979990887 6 O96028,P48651,O95202 3 +Neoplasm of the small intestine 0.7185193317619587 1.740604936415672 0.0817528517680639 1.0 0.5332981979990887 6 P02545,P21912 2 +Death in infancy 0.4271172785952887 1.7402191019560524 0.081820552708975 1.0 0.5332981979990887 55 P16278,Q9HC21,Q6NUK1,P07602,P02545,Q9BT22,Q15904,Q9NZJ7,P04062,Q12768,O43819,P40855,O75381 13 +Enlarged ovaries 0.7531791314906919 1.739905248464238 0.0818756569542169 1.0 0.5332981979990887 5 P16435,P10644,P21912 3 +Toxemia of pregnancy 0.717922966882214 1.737799097558938 0.0822462197525859 1.0 0.5349509094418907 6 P49366,P02545,Q14739 3 +Hypoketotic hypoglycemia 0.6638958226309941 1.7361036221776127 0.0825455140366879 1.0 0.535376641322938 8 P40939,P23786,Q16836,P50416 4 +Furrowed tongue 0.6906781079143328 1.735284913939296 0.0826903525161069 1.0 0.5354339823817358 7 Q99643,Q15437,P21912,Q96J42 4 +Hepatosplenomegaly 0.4696591970154824 1.7347323696976835 0.0827882200319434 1.0 0.5354339823817358 41 P16278,Q96HY6,Q9UJS0,P04637,Q5HYI8,P04062,P38398,Q13510,P10619,P51798,Q14739,O00203 12 +Endocarditis 0.7518198156194017 1.733854909362179 0.0829438300900313 1.0 0.5356837771258867 5 Q9NZ08,P04062 2 +Adrenal hypoplasia 0.6096139200988966 1.730881930246683 0.083472825106734 1.0 0.5377529513990261 11 O75844,P02545 2 +Infectious encephalitis 0.6624882951216543 1.728863681033889 0.0838334955752677 1.0 0.5377529513990261 8 Q9H9P8,Q14739 2 +Pseudoepiphyses of hand bones 0.7503576040753115 1.7273430166816726 0.0841060779439308 1.0 0.5377529513990261 5 O96028,O95202 2 +Pseudoepiphyses 0.7503576040753115 1.7273430166816726 0.0841060779439308 1.0 0.5377529513990261 5 O96028,O95202 2 +Pulmonary infiltrates 0.6888470469105079 1.7262807432913665 0.0842969180057247 1.0 0.5377529513990261 7 P04062,Q13510 2 +Heterogeneous 0.4678418275234055 1.718873831338132 0.0856373480633401 1.0 0.543711732326988 41 O75844,P02545,P21964,P07196,Q9NR77,Q8TB36,P04637,P38398,P05067,P61916,O75330,P12235,P03886,P40939,P51798,Q16836,Q9Y619 17 +Abnormality of the cerebrospinal fluid 0.4587426102101021 1.71737299774641 0.0859110420806665 1.0 0.5440269852170962 139 Q9P0J0,Q9HC21,Q9BXW9,Q15392,O43681,Q7KZN9,P55011,O43819,Q10713,P40855,P03886,O43676,O60566,P10644,O00754,P07602,Q6NUK1,Q96CU9,P00403,O96028,Q03252,P39210,Q12768,Q86Y39,P48651,P51798,Q9UBM7,O95202,P16435,O95831,P20700,Q96J42,Q9NR77,P13073,O95299,P04062,O96000,Q9Y6M9,Q15125,P23786,O95140,P04637,Q9NZJ7,P38398,P53701,P51970,P21964 47 +Abnormality of the shoulder girdle musculature 0.4857555820832411 1.7157337829605783 0.086210778567477 1.0 0.5440269852170962 32 O60313,P02545,P07602,P07196,P50402,Q8TD16,Q9NZJ7,Q9Y487,P12235 9 +Abnormal sensory nerve conduction velocity 0.7131743002382629 1.715431540686306 0.0862661368146475 1.0 0.5440269852170962 6 O15269,Q9NR77 2 +Fetal ultrasound soft marker 0.539129777455398 1.709955036330873 0.0872741879714789 1.0 0.548182084182928 17 P40855,Q15125,Q12768,O75381 4 +Abnormal rib cage morphology 0.3962549589118422 1.7053541784408135 0.0881283887511823 1.0 0.5493411835368478 77 P34059,Q15427,P54802,Q9UHX1,Q9UM00,O00754,P16278,O14656,Q96L58,O96028,Q12768,P48651,P51798,Q9UBM7,Q04656,Q01968,O75844,O95202,P02545,P16435,O95831,Q8TAA9,Q53GS7,O75431,Q14739,Q96HY6,P15586,P07237,Q5H8A4,Q32P28,Q9Y619 31 +Abnormal cranial nerve physiology 0.3905519564410629 1.7039294967022756 0.0883942595940447 1.0 0.5493411835368478 72 Q9BXW9,P07196,P51530,Q9UHX1,O43819,P53007,P40855,P07602,Q13510,P48651,P51798,P02545,Q9NR77,Q9NZ08,Q15043,P51812,P21912,Q9NZJ7,P38398,P12235,O75381 21 +Secondary microcephaly 0.3892324885449548 1.701684781132566 0.0888144748386394 1.0 0.5493411835368478 71 Q13144,P50897,Q9HC21,Q5XKP0,Q9Y263,Q9NQT5,Q9BT22,Q96CU9,Q15043,Q5KU26,Q9UHX1,Q9Y487,Q86Y39,O75208,O75962 15 +Abnormal pupillary function 0.6837508049453414 1.7011805728501783 0.0889090846828124 1.0 0.5493411835368478 7 P07602,Q9NZJ7 2 +Short nail 0.7100981143888265 1.7009178227106845 0.0889584193985704 1.0 0.5493411835368478 6 O75844,P02545 2 +Proptosis 0.4153620201118719 1.6965831816026 0.0897754916988677 1.0 0.5510482258567233 57 P16435,O75844,O00754,P02545,Q6NUK1,O43175,Q9BXW9,Q9NX62,P52788,Q96L58,O96028,Q5KU26,Q15043,P38398,Q5H8A4,O75431,Q9UBM7,O95202 18 +Aplasia hypoplasia involving bones of the thorax 0.4773669535356468 1.6900196670382883 0.0910241921338825 1.0 0.5579648939505332 35 P16435,O75844,P02545,Q96HY6,O14656,Q96L58,Q8TAA9,Q14739,Q12768,Q9UHX1,Q9Y619,P48651,O75431,O60566,Q04656 15 +Abnormal systemic blood pressure 0.4110319434868103 1.6892267057932513 0.0911759930331583 1.0 0.5581482247310591 92 O43681,Q10713,P03886,P07602,P42892,Q9Y4P3,P06280,P00403,Q13423,Q04656,O75844,P16435,P02545,P20700,P04062,Q15645,P04637,Q9NZJ7,P21964 19 +Retinal coloboma 0.6277913289961103 1.6878639335501633 0.0914373513847752 1.0 0.559000843779554 9 Q9UHX1 1 +Thoracic kyphosis 0.5473895459834657 1.6821241338730302 0.0925447714400853 1.0 0.5611101585701048 15 Q9UHX1,P51648 2 +External ear malformation 0.5473654196892094 1.6819683413146074 0.0925749790611338 1.0 0.5611101585701048 15 Q9BXW9,Q8NCH0,P38398,P56589,P40855,O75381 6 +Prominent umbilicus 0.9798073936004972 1.680370577160642 0.0928852369941339 1.0 0.5611101585701048 2 O75844 1 +Abnormal sweat gland morphology 0.9798073936004972 1.680370577160642 0.0928852369941339 1.0 0.5611101585701048 2 O75844 1 +Epidermal hyperkeratosis 0.9798073936004972 1.680370577160642 0.0928852369941339 1.0 0.5611101585701048 2 O75844 1 +Stiff skin 0.9798073936004972 1.680370577160642 0.0928852369941339 1.0 0.5611101585701048 2 O75844 1 +Severe failure to thrive 0.9798073936004972 1.680370577160642 0.0928852369941339 1.0 0.5611101585701048 2 O75844 1 +Aplasia hypoplasia of the colon 0.9798073936004972 1.680370577160642 0.0928852369941339 1.0 0.5611101585701048 2 O75844 1 +Proximal tubulopathy 0.4905190539058782 1.6749815459725133 0.093937852458759 1.0 0.5652180027802934 24 Q96CU9,Q86Y39,Q9Y6M9,P03886,O43676 5 +Aortic valve calcification 0.9754505904288372 1.6748803633436042 0.0939577071216861 1.0 0.5652180027802934 3 O75844,P02545 2 +Purpura 0.4987555343028452 1.6732033935052837 0.094287262540146 1.0 0.5652180027802934 22 P04062,P21964,Q8NCH0,P38435 4 +Basal ganglia calcification 0.6777058758900129 1.67133332879419 0.0946558568055686 1.0 0.5652180027802934 7 P03886,P00403 2 +Abnormal circulating citrulline concentration 0.8383676011936539 1.6679142772725717 0.0953327450299597 1.0 0.5652180027802934 4 P03886,Q9UJS0 2 +Cirrhosis 0.4619800656619013 1.6675541327317074 0.0954042699142359 1.0 0.5652180027802934 41 P22830,Q9UJS0,P04637,Q15904,P04062,P39210,Q10713,Q14108,P35670,Q14739 10 +Bulbar palsy 0.6111504809515568 1.6658927329255413 0.0957347813082591 1.0 0.5652180027802934 10 P53007,O43681 2 +Abnormality of the fetal cardiovascular system 0.7363639324293616 1.6648396253940334 0.0959447560193464 1.0 0.5652180027802934 5 Q12768 1 +Thin ribs 0.5717537605011008 1.6644296993692198 0.0960265890611673 1.0 0.5652180027802934 13 O75844,P02545,O75431,Q9Y619 4 +Abnormal heart rate variability 0.8373601820682994 1.6637923006830202 0.096153943149992 1.0 0.5652180027802934 4 P07602 1 +Atrioventricular canal defect 0.6233133257796638 1.6635885011630749 0.0961946913855933 1.0 0.5652180027802934 9 O75962,Q12768,Q9UHX1 3 +Depletion of mitochondrial dna in muscle tissue 0.7357372106876227 1.6620327355343094 0.0965062110045067 1.0 0.5653250083978238 5 Q9UBX3 1 +Limb pain 0.6494983159448245 1.6618124401453924 0.0965503871359043 1.0 0.5653250083978238 8 O95140,Q8WVX9,O15269,O75477 4 +Polydactyly 0.4361890491491121 1.6599595505131362 0.0969225901406216 1.0 0.5653250083978238 50 P21964,Q96J42,Q9BXW9,Q9Y263,O96028,Q12768,Q9UHX1,Q10713,Q5H8A4,Q15125,Q9UBM7,Q14739,O95202 13 +Abnormal morphology of the conjunctival vasculature 0.6491000524292156 1.6597501132367556 0.096964733364814 1.0 0.5653250083978238 8 Q9NW15,P06280,P10619 3 +Muscle stiffness 0.5182270981374115 1.6583185292774256 0.0972531909715872 1.0 0.5653250083978238 19 Q15392,Q9NW15,P07602,Q9NZJ7 4 +Osteolytic defects of the distal phalanges of the hand 0.8344780432320954 1.6519936523337535 0.0985358448618733 1.0 0.571096456819746 4 O75844,P02545 2 +Decreased calvarial ossification 0.8341463467117669 1.6506352136359634 0.0988130839879348 1.0 0.571096456819746 4 O75844 1 +Urticaria 0.608409323139952 1.650598751680893 0.0988205339565964 1.0 0.571096456819746 10 Q99643,P21912,P51648,Q15427 4 +Sensory ataxia 0.7330950797081675 1.650192455411336 0.0989035794405019 1.0 0.571096456819746 5 P54802 1 +Premature graying of hair 0.6730944835035046 1.6485107852622751 0.0992478993453669 1.0 0.5723628855194397 7 P02545 1 +Preaxial polydactyly 0.555175284987554 1.6443217568884367 0.1001097575175158 1.0 0.5753042131542742 14 Q5H8A4,Q9UHX1,Q96J42,O95202 4 +Mottled pigmentation 0.9674023588252094 1.6440317503824 0.1001696441557322 1.0 0.5753042131542742 3 O75844 1 +Proximal muscle weakness in upper limbs 0.5413953921097403 1.6433441625372256 0.1003117458883462 1.0 0.5753042131542742 15 P02545,Q9BTV4,P07196,P50402,O95140,P50336,Q8WXH0 7 +Aplasia hypoplasia of the clavicles 0.5942939661598627 1.6432207897197109 0.1003372599773109 1.0 0.5753042131542742 11 O75844,P02545,Q9Y619,O75431,Q04656 5 +Poor motor coordination 0.567458456442054 1.6382848890735044 0.1013622783971737 1.0 0.5757264841823472 13 O75503,P35670,Q10713,Q96RL7 4 +Angina pectoris 0.8310052453816624 1.637765326167255 0.101470657298504 1.0 0.5757264841823472 4 O75844,P02545 2 +Abnormality of hair pigmentation 0.5011121989168938 1.6363316936806995 0.1017701864006943 1.0 0.5757264841823472 21 P10644,P02545,P37268,Q13126,Q9UBM7,Q04656,O00203 7 +Dyschromatopsia 0.6444724871948834 1.6357590438371852 0.1018900268036875 1.0 0.5757264841823472 8 Q9H061,Q9H6K4 2 +Spastic paraparetic gait 0.7296908911825026 1.6349206069056148 0.102065691999496 1.0 0.5757264841823472 5 Q15041,Q15043 2 +Generalized lipodystrophy 0.8293063116145958 1.630800088257287 0.1029325088320871 1.0 0.576488029246945 4 O75844,P02545 2 +Malrotation of small bowel 0.8291332622829716 1.6300904592265464 0.1030823798627069 1.0 0.576488029246945 4 Q8NCH0,O95202 2 +Thoracic hypoplasia 0.4735146808447525 1.62940157659637 0.1032280352611312 1.0 0.576488029246945 33 P02545,P04062,Q96A33,Q9UHX1,P51798,Q14739,Q04656 7 +Abnormal ldl cholesterol concentration 0.5391454061294935 1.628749792244425 0.1033659973104654 1.0 0.576488029246945 15 P02545,Q8N511,Q9UJS0,P37268,Q15800 5 +Diffuse cerebral atrophy 0.5203128354714704 1.6266308594138807 0.1038155211627887 1.0 0.576488029246945 18 P16278,P07602,Q9NZJ7,Q10713 4 +Osteomyelitis 0.5327338793990904 1.625691981533533 0.1040151966815656 1.0 0.576488029246945 16 Q13126,P39210,P51798,O15269 4 +Calvarial skull defect 0.6162883053866578 1.6253944309660813 0.1040785417768261 1.0 0.576488029246945 9 Q5H8A4,Q14739,O95202 3 +Hyperesthesia 0.9661385523454472 1.6244471475956022 0.1042804116305062 1.0 0.576488029246945 2 P07602 1 +Myoclonus 0.3990436822951843 1.6237444333853075 0.1044303636530343 1.0 0.576488029246945 86 P50897,P07602,Q01105,Q9UBX3,P13073,Q96CU9,Q96AA3,Q9NZJ7,P00403,O14656,P04062,P05067,Q13510,O75503,Q03252,Q10713,P03886,Q14108 18 +Delayed puberty 0.4121188252572595 1.623619305081758 0.1044570827053674 1.0 0.576488029246945 56 O75844,P02545,Q9NVI7,Q9UJS0,P06280,P04062,Q15800,Q14108,O76024 9 +Abnormal dermatoglyphics 0.3801994161225276 1.6220782379172634 0.1047865971400456 1.0 0.576488029246945 69 Q9UHX1,P56589,P40855,Q99567,Q6NUK1,Q9Y4P3,O96028,Q9UBM7,Q8WVM7,O95202,Q69YQ0,P51812,Q15056,Q53GS7,O75431,Q8IY17,Q9Y263,Q8NCH0,Q96S52,Q969X5,Q9Y487,O75381 22 +Abnormal venous morphology 0.479545877351683 1.6215185178294234 0.1049064818457365 1.0 0.576488029246945 28 P02545,Q6NUK1,P04062,Q9Y487,P21964,Q04656 6 +Weak voice 0.6930026921082106 1.6199256322186375 0.1052482529738567 1.0 0.576488029246945 6 P04062 1 +Distal sensory impairment of all modalities 0.7261538709200146 1.6190334196291822 0.1054400727311288 1.0 0.576488029246945 5 O15269 1 +Symptomatic seizures 0.6147831095590975 1.6171934791908122 0.1058365234677163 1.0 0.576488029246945 9 Q13423,P40939 2 +Progressive external ophthalmoplegia 0.6023815869123187 1.616890823183022 0.1059018496472035 1.0 0.576488029246945 10 O60313,P03886,P12235,P00403 4 +Distal peripheral sensory neuropathy 0.8258574053320372 1.6166513070688795 0.105953570187981 1.0 0.576488029246945 4 P03886,P40939 2 +Abnormally lax or hyperextensible skin 0.4533583111234672 1.6124846173150595 0.106856524659465 1.0 0.5784252144464873 42 Q9NWM8,Q6NUK1,P38435,Q8NCH0,Q15904,Q9Y4P3,O96000,O75787,P04062,Q9UHX1,Q9Y487,P48651,Q04656 13 +Drowsiness 0.6654375214527624 1.610515232128886 0.1072854228559434 1.0 0.5798304170278347 7 Q5H8A4,Q9UJS0 2 +Diffuse white matter abnormalities 0.6652444360731778 1.6095555127817596 0.1074949268184213 1.0 0.5798304170278347 7 O75306,P16278,O43819 3 +Abnormality of lipoprotein cholesterol concentration 0.5301048870686691 1.6082958997953232 0.1077703882397584 1.0 0.5798304170278347 16 P02545,Q8N511,Q9UJS0,P37268,Q15800 5 +Cranial asymmetry 0.6902579564619525 1.6068707481537077 0.108082724452291 1.0 0.5798304170278347 6 O96028,P40855,O95202 3 +Bifid scrotum 0.6901566547312826 1.6063886593388714 0.1081885410642993 1.0 0.5798304170278347 6 P16435,Q9UBM7,O60566 3 +Abnormal pupil morphology 0.5877778105572061 1.60571251685144 0.1083370898259661 1.0 0.5798304170278347 11 O96028,O95202 2 +Cerebral visual impairment 0.375343716575272 1.6049984019432528 0.1084941563586419 1.0 0.5798304170278347 66 O43175,P20700,Q01105,Q96CU9,P37268,Q96N66,P00403,Q96A33,P12235,P03886,Q9NZ01 11 +Tetraplegia 0.5745293496092269 1.6037993933399988 0.1087582783700029 1.0 0.5798304170278347 12 Q13423,P51572,O95831,O43681 4 +Morphological abnormality of the corticospinal tract 0.5351742195209683 1.602941270500478 0.1089476209077542 1.0 0.5798304170278347 15 O00400,Q12768,Q9Y4P3 3 +Hypointensity of cerebral white matter on mri 0.6637881407718912 1.6023146027767543 0.1090860581329671 1.0 0.5798304170278347 7 P07602 1 +Redundant neck skin 0.6635586801552221 1.6011732930864024 0.1093385423217589 1.0 0.5798304170278347 7 O96000,P36543,Q9Y487 3 +Abnormal liver physiology 0.6889480382954996 1.600635487504325 0.1094576774471032 1.0 0.5798304170278347 6 Q13510 1 +Abnormal circulating free fatty acid concentration 0.8215489528080226 1.5989596614899917 0.1098295659759502 1.0 0.5798304170278347 4 P40939,Q16836 2 +Lower limb spasticity 0.3904214238531658 1.5985831482090005 0.1099132566019132 1.0 0.5798304170278347 80 Q9P0J0,O60313,O00400,Q7KZN9,O75787,P07602,Q96CU9,Q12768,O95831,O95299,P04062,O75298,Q15041,Q99720,P21912,Q9H6K4,Q9UBB4,Q5XKP0,Q9NZJ7,Q9Y619 20 +Segmental peripheral demyelination remyelination 0.8207869899599767 1.5958289554865333 0.1105269866727955 1.0 0.5814504482555042 4 P03886,Q9NR77 2 +Calvarial hyperostosis 0.7207902611216264 1.5949047394490836 0.11073353963693 1.0 0.5814504482555042 5 Q15043 1 +Cerebral white matter atrophy 0.4952983065949005 1.5938874350986152 0.1109612491808342 1.0 0.5814504482555042 21 O60313,Q9H9P8,P20700,O43175,Q9Y263,P51572,O75503,P51970,Q2TAA5 9 +Profound global developmental delay 0.5471261775844781 1.593656060569684 0.1110130907433977 1.0 0.5814504482555042 14 O60313,P37268,P55011,P56589,P40855,O75381 6 +Abnormal sternal ossification 0.8202407384866526 1.593584207583493 0.111029193947342 1.0 0.5814504482555042 4 Q9Y619,O95202 2 +Supernumerary tooth 0.6871794834702759 1.5922121731425252 0.111337038930926 1.0 0.5814504482555042 6 Q9UHX1 1 +Acute coronary syndrome 0.5085723155549466 1.5907170213034187 0.1116732745136381 1.0 0.5814504482555042 19 O75844,P02545,Q9NZ08,P06280,Q9Y4P3 5 +Hypoglycemic coma 0.6096845395704128 1.5893693857009927 0.1119770220849118 1.0 0.5814504482555042 9 Q13423,P40939,Q16836,Q16134 4 +Bilateral tonic clonic seizure with generalized onset 0.6092482206905245 1.5869851003131257 0.1125160192228966 1.0 0.5814504482555042 9 P04062,Q13510 2 +Thin skin 0.4789820614668661 1.58657665236711 0.1126085587952439 1.0 0.5814504482555042 24 O75844,Q96PU5,P02545,P10644,Q13126,O75431,Q9Y619 7 +Abnormal sella turcica morphology 0.6605260511575576 1.586079241509159 0.1127213351668918 1.0 0.5814504482555042 7 O00754,O75431,P16278,Q9UNE7 4 +Subcutaneous hemorrhage 0.4548279117710289 1.5847420547569304 0.1130249526245115 1.0 0.5814504482555042 40 Q9NWM8,P21964,P38435,Q8NCH0,P04062,Q13126,Q14108,P51798,P35670,Q04656 10 +Inappropriate crying 0.6602488765305194 1.5846987502918215 0.1130347959638815 1.0 0.5814504482555042 7 P07602,Q9NZJ7 2 +Onion bulb formation 0.6346310692739712 1.5845681030301026 0.1130644968871803 1.0 0.5814504482555042 8 P07196,Q8TB36,P02545,Q9NR77 4 +Abnormality of the pubic bone 0.6084771112199292 1.5827701161351546 0.1134738703504265 1.0 0.5814504482555042 9 O96028,Q5H8A4,Q8IZA0,O95202 4 +Vertebral segmentation defect 0.4732663900582102 1.5812021665559592 0.1138318201564194 1.0 0.5814504482555042 29 Q9Y4P3,O96028,Q12768,Q9UHX1,Q15125,Q9Y619,O95202 7 +Large placenta 0.9506426368114242 1.5796737468224042 0.114181600844434 1.0 0.5814504482555042 3 O75844 1 +Abnormal brain choline level by mrs 0.9506074189425616 1.5795383577391782 0.114212625546854 1.0 0.5814504482555042 3 P07602 1 +Reduced brain n acetyl aspartate level by mrs 0.9506074189425616 1.5795383577391782 0.114212625546854 1.0 0.5814504482555042 3 P07602 1 +Abnormal brain n acetyl aspartate level by mrs 0.9506074189425616 1.5795383577391782 0.114212625546854 1.0 0.5814504482555042 3 P07602 1 +Developmental cataract 0.4114017578966491 1.5790699757764055 0.1143200074811354 1.0 0.5814504482555042 55 P02545,Q9NVI7,O00400,O43175,Q99797,Q53H12,Q15800,P03886,O76024 9 +Oligosacchariduria 0.7172330508452951 1.5788782338591558 0.1143639894312293 1.0 0.5814504482555042 5 P10253,O00754,P16278 3 +Osteomalacia 0.6842019202566343 1.578017908357178 0.114561495704073 1.0 0.5814504482555042 6 P35670,O43175 2 +Abnormal periventricular white matter morphology 0.4560553997643228 1.576662521903946 0.1148731983209097 1.0 0.5814504482555042 39 P07602,P17900,O43681,Q9NZJ7,O96028,O75503,Q9UHX1,P51571,O95202 9 +Stenosis of the external auditory canal 0.6584427794718188 1.575699538604154 0.1150950638457635 1.0 0.5814504482555042 7 P16435,O96028,O95202 3 +Short umbilical cord 0.9493474207582306 1.5746941302610162 0.1153270633478977 1.0 0.5814504482555042 3 O75844,P02545 2 +Small placenta 0.9493474207582306 1.5746941302610162 0.1153270633478977 1.0 0.5814504482555042 3 O75844,P02545 2 +Redundant skin 0.4765168802784385 1.5738965156021294 0.1155113756111099 1.0 0.5814504482555042 25 Q6NUK1,P38435,Q8NCH0,Q9Y4P3,O96000,Q9Y487,P48651,Q04656 8 +Abnormal blood transition element cation concentration 0.5434761562204209 1.5706015669486604 0.1162752257777504 1.0 0.5831444622974032 14 P35670,Q9Y487,O43819 3 +Atrophy degeneration involving the corticospinal tracts 0.5563005731289372 1.5700664234510484 0.1163996589953759 1.0 0.5831444622974032 13 O00400,Q12768,Q9Y4P3 3 +Generalized joint laxity 0.5686912384740797 1.569083815071608 0.1166284105101862 1.0 0.5836519035258391 12 Q8NCH0,Q9UHX1 2 +Abnormal femoral neck head morphology 0.4354498878364986 1.5676564627932268 0.1169613273665972 1.0 0.5840413500672288 47 O75844,P16278,O00754,P02545,O95831,Q96HY6,Q96AY3,Q96L58,Q96A33,Q7LGA3,P51812,P55011,Q9Y487,Q9Y619,O75431,Q14739,Q04656 17 +Low set posteriorly rotated ears 0.3787526780735232 1.5650710351745314 0.1175662542225493 1.0 0.5855709955168927 72 Q4J6C6,Q15427,Q15392,P56589,Q10713,P40855,Q9UM00,O60566,Q6NUK1,Q9Y4P3,Q96L58,O96028,Q9UBM7,Q01968,P16435,O95202,Q96J42,P04062,Q15555,Q15056,Q53GS7,Q15645,Q8IY17,Q9Y263,P37268,Q8NCH0,Q5H8A4,O75381 28 +Dermatological manifestations of systemic disorders 0.3841219389810197 1.563059157298928 0.1180386810677669 1.0 0.5865556540840475 77 P00374,Q5HYI8,O75787,P56589,P53007,P40855,P10644,P39210,P35670,Q04656,O15118,O75844,P02545,Q16134,O75648,P61916,P51812,Q14739,Q9UJS0,P04637,Q15904,P38398,P11413,O75381 24 +Abnormality of the synovia 0.3873675033212552 1.5626678324444785 0.1181307442909544 1.0 0.5865556540840475 80 Q9BXW9,Q9NQT5,Q9UHX1,P55011,P53007,P16278,O14656,Q96L58,O96028,Q03252,Q9UBM7,Q04656,O95202,O75844,P16435,P02545,P57678,Q8TD16,Q96AY3,P38398,Q96A33,Q969X5,Q9Y487,O00203 24 +Urinary bladder sphincter dysfunction 0.604723745025807 1.56223164438976 0.1182334284165922 1.0 0.5865556540840475 9 Q12768,Q9NR77 2 +Dermal atrophy 0.4730535535518077 1.5616209737268052 0.1183773055324195 1.0 0.5866338550140142 27 O75844,Q9NWM8,P02545,Q15392,P04637,Q8NCH0,P53701 7 +Sporadic 0.4746893728126642 1.5597067135440632 0.1188292049147388 1.0 0.5882366803292854 25 Q69YQ0,Q03252,Q99643,O96028,P04062,P51812,P48651,P21912,O95202 9 +Decreased muscle mass 0.5104955818285607 1.5590205343824788 0.1189915200916618 1.0 0.5884040718139518 18 Q8NCH0,P52788,O96028,Q9Y487,O95202 5 +Occipital meningocele 0.6549871387068492 1.5584629983431368 0.1191235327566118 1.0 0.5884214201645367 7 P21964 1 +Jaundice 0.3785384575799097 1.555443210788137 0.119840549695809 1.0 0.5906887804705162 63 Q5HYI8,P00374,O75787,P56589,P40855,P10644,P39210,P35670,O15118,Q04656,Q16134,O75648,P61916,Q14739,Q9UJS0,P04637,Q15904,P38398,P11413,O75381 20 +Abnormal macrophage morphology 0.6792195105984913 1.554231471789311 0.1201292129940978 1.0 0.5914749099999721 6 P16278,Q13510,O15118 3 +Short lingual frenulum 0.8103362650789226 1.5528348860415748 0.1204625859592218 1.0 0.5924792493096424 4 O75844 1 +Ambiguous genitalia 0.4893009039260181 1.5499203271744808 0.1211606400972646 1.0 0.5935982523664479 21 P16435,O43175,Q96J42,Q15392,P53701,Q15645,Q9UBM7,O60566 8 +Abnormality of exocrine pancreas physiology 0.489289629007569 1.5498374975749922 0.1211805244237083 1.0 0.5935982523664479 21 P09601,P04637,Q15904,Q5HYI8,Q9UHX1 5 +Blindness 0.3862424717678139 1.5494089023871769 0.1212834550759651 1.0 0.5935982523664479 80 P21912,P16278,P50897,P07602,P17900,Q9NZ08,Q96CU9,Q9NZJ7,O96000,P53701,P06865,Q86Y39,Q9Y6M9,P03886,P51798,O43676,Q9H6K4 17 +Coarse hair 0.4890506180060938 1.5480814854080052 0.1216026790994087 1.0 0.5935982523664479 21 Q6NUK1,P36543,Q04721,P54802,Q96A33,P51812,Q9Y487,Q9UM00,Q04656 9 +Elbow flexion contracture 0.4713070951221399 1.5478494011958528 0.1216585593172567 1.0 0.5935982523664479 27 P16435,P02545,P50402,Q96AY3,P37268,O14656,Q96L58,O94905,Q7LGA3,Q8WXH0,P48651,P23786 12 +Pericarditis 0.7101990049751205 1.5471325269352596 0.1218312919617794 1.0 0.5935982523664479 5 Q9NZ08,P49327,O15460,P14174 4 +Slow saccadic eye movements 0.5898316446936365 1.5463794203963803 0.1220129613274729 1.0 0.5935982523664479 10 P04062,Q8IV08 2 +Insulin resistant diabetes mellitus 0.6017980476229292 1.5461970564618144 0.1220569841996939 1.0 0.5935982523664479 9 O75844,P02545 2 +Back pain 0.4717122773782066 1.5434010144421737 0.1227335077105844 1.0 0.5935982523664479 26 Q8WVX9,P02545,Q9BTV4,P50402,Q9UGP8,P04637,P54886,Q8TAA9,Q5HYI8,P38398,P50336,Q8WXH0,P51798,P35670 14 +Congenital malformation of the right heart 0.6516844613684599 1.5419674534451104 0.123081502768487 1.0 0.5935982523664479 7 P40855,Q12768 2 +Abnormal femoral neck morphology 0.4520460665746389 1.541775531651311 0.1231281499619907 1.0 0.5935982523664479 39 O75844,O00754,P16278,P02545,O95831,Q96HY6,Q96AY3,Q96L58,Q96A33,P51812,P55011,Q9Y487,Q9Y619,O75431,Q04656 15 +Retinal vascular tortuosity 0.5389068837608137 1.541672637504139 0.1231531643913792 1.0 0.5935982523664479 14 P03886,P21964 2 +Extrapyramidal muscular rigidity 0.6762135127747773 1.5398598736766225 0.1235945136115037 1.0 0.594802571069276 6 O75787,Q9H6K4 2 +Type ii transferrin isoform profile 0.708527817480086 1.5395797736331198 0.1236628188814044 1.0 0.594802571069276 5 Q15904 1 +Decreased number of large peripheral myelinated nerve fibers 0.6759574144382411 1.5386347650577563 0.1238934863415601 1.0 0.5952867512675802 6 Q8TB36,O15269 2 +Hyperextensible skin 0.5510194480459166 1.537629606640731 0.1241392041681612 1.0 0.5958421550167824 13 P04062,Q8NCH0,Q9UHX1,Q04656 4 +Arthrogryposis multiplex congenita 0.4471417498718541 1.5365083867265132 0.1244137424603288 1.0 0.5960816022606125 41 O75844,P02545,O43175,Q15392,Q53GS7,Q9UPT5,Q8TD16,Q96AA3,O14656,Q96AY3,Q8NCH0,P04062,Q96S52,Q969X5,P53007,Q99567,Q53EZ4 17 +Posterior fossa cyst 0.944392668530596 1.5353761147054004 0.1246914673317294 1.0 0.5960816022606125 2 Q9UHX1 1 +Abnormal palmar dermatoglyphics 0.4035951587219072 1.534426774317667 0.1249246949527218 1.0 0.596486108642871 56 Q8IY17,Q6NUK1,Q9Y263,Q69YQ0,Q8NCH0,O96028,Q96S52,P51812,O75431,Q9UHX1,P56589,Q9Y487,Q53GS7,P40855,Q99567,O75381,Q8WVM7,O95202 18 +Unusual infection by anatomical site 0.5626929860609781 1.5333034329852266 0.1252011091611546 1.0 0.5966216595227627 12 Q9NZ08,Q9H9P8,Q14739,O15460 4 +Positive romberg sign 0.5875037279883517 1.5332524143314192 0.1252136743396756 1.0 0.5966216595227627 10 Q8IV08,Q9H6K4,P07196 3 +Female hypogonadism 0.7068946565491343 1.5321950956914638 0.1254742984171728 1.0 0.5966355533748727 5 O75844 1 +Hyperkeratosis 0.4033816501023449 1.5321833878890776 0.1254771867001534 1.0 0.5966355533748727 56 O75844,P02545,P98194,P06280,P04062,O15269,P51648,O75431,Q06136,P16615,P42167 11 +Proximal muscle weakness in lower limbs 0.4793182965329312 1.5280508193407154 0.1264999208341144 1.0 0.5988417600781512 22 Q00796,P02545,Q16637,P07196,P50402,O95140,Q8WXH0,P12235,P35670 9 +Progressive sensorineural hearing impairment 0.5863637404081914 1.5268187717793924 0.1268060823990628 1.0 0.5988417600781512 10 P03886,O76024,P00403 3 +Saccadic oscillation 0.9422180801491122 1.5264655539447998 0.1268939626821963 1.0 0.5988417600781512 2 P04062 1 +Opsoclonus 0.9422180801491122 1.5264655539447998 0.1268939626821963 1.0 0.5988417600781512 2 P04062 1 +Abducens palsy 0.803662332733105 1.5253278918349658 0.1271773342421895 1.0 0.5988417600781512 4 P07602 1 +Color vision defect 0.5175087503245444 1.5245529123903183 0.1273706497426252 1.0 0.5988417600781512 16 O60313,Q8WWV3,Q9H061,Q6P4Q7,Q9H6K4 5 +Prominent ear helix 0.8034635340023883 1.524507961430703 0.1273818695892492 1.0 0.5988417600781512 4 O75844 1 +Hallucinations 0.4411118088748881 1.523992719788112 0.1275105298266428 1.0 0.5988417600781512 43 O60313,P50897,P07602,Q9UJS0,O43681,Q9NZJ7,P05067,P04062,O75503,P21964,O76024 11 +Aplasia hypoplasia of the lungs 0.4570835816652451 1.5204413048078205 0.1284001000156107 1.0 0.602108605614436 35 O75844,P02545,Q6NUK1,O43175,Q16134,Q69YQ0,Q96L58,O96028,O96000,Q5H8A4,Q9UBM7,Q14739,O95202 13 +Abnormal cry 0.5481824807425109 1.5201665518783476 0.128469121573554 1.0 0.602108605614436 13 O60313,Q13510,O75208,P53007 4 +Congenital ichthyosiform erythroderma 0.6719109187655473 1.519262815935264 0.1286963553980169 1.0 0.6025568623389771 6 P04062 1 +Bladder neoplasm 0.6218210833304689 1.5176041928098825 0.12911420925128 1.0 0.6025879298375093 8 P04637,Q04656 2 +Titubation 0.5965840843234701 1.5175678435215063 0.1291233784473509 1.0 0.6025879298375093 9 Q99720,P20700,Q5T8D3,Q96RL7 4 +Aortic regurgitation 0.469990788878294 1.5171477549560786 0.1292293835117786 1.0 0.6025879298375093 24 O75844,Q96PU5,P02545,Q9NZ08,Q9UHX1,Q15645,O60566 7 +Corneal ulceration 0.7031913349478116 1.515436134323737 0.1296619924236979 1.0 0.6038950242971957 5 O75844 1 +Abnormality of the musculature of the lower limbs 0.4677799671593264 1.512538951577763 0.1303968112955975 1.0 0.6038950242971957 26 P02545,P07196,P50402,Q9NR77,O14979,Q9NW15,Q12768,P53007,Q96RL7 9 +Abnormality of the ureter 0.3730562639884251 1.5106988563060062 0.1308651939505674 1.0 0.6038950242971957 71 P16435,O14578,P02545,O75844,Q96J42,Q9BXW9,Q69YQ0,Q9Y4P3,Q86XL3,P38398,Q7LGA3,Q9UHX1,P23786,P21964,Q9UBM7,P21912,Q04656,O76024 18 +Chordee 0.7020741059136214 1.5103765883704277 0.1309473589854528 1.0 0.6038950242971957 5 P16435,P53701 2 +Abnormality of facial adipose tissue 0.7995276738266472 1.5082682828649467 0.1314858773518428 1.0 0.6057080808793645 4 O75844,P02545 2 +Severe short stature 0.4692796475322401 1.5064429926166494 0.1319534910894653 1.0 0.6072512921594588 23 P16278,Q8IY17,Q96HY6,Q15392,Q96EY7,Q96L58,P53701,P10619,P48651,P21912,Q9Y619 11 +Weakness of muscles of respiration 0.4516120238684589 1.5040934399660677 0.1325573091719272 1.0 0.6092708498632312 37 P02545,O95831,P50402,O95140,Q8TD16,P10253,Q13510,Q8WXH0,P53007,P12235 10 +Progressive pes cavus 0.7004667671137674 1.5030945824342632 0.1328146556606892 1.0 0.6092708498632312 5 O00400,Q12768 2 +Hypoplasia of the iris 0.6435363333374997 1.5011815186406536 0.133308618748722 1.0 0.6092708498632312 7 Q7LGA3,O95202 2 +Abnormality of the nasal dorsum 0.4105319989289593 1.5011230540757912 0.1333237369650486 1.0 0.6092708498632312 53 O75844,P10644,P16278,P02545,Q6NUK1,O43175,Q96J42,P51530,O96028,Q15645,Q15125,O75431,O60566,Q04656,O95202 15 +Hypercholesterolemia 0.5442409434456192 1.495860669180216 0.1346899674557735 1.0 0.6130669592246393 13 O75431,P02545,Q8N511,Q9UJS0 4 +External ophthalmoplegia 0.5071762229230977 1.4942753435466671 0.1351036668946552 1.0 0.6143393155021116 17 O60313,Q13509,P51530,P00403,P12235,P03886,P21912 7 +Primary adrenal insufficiency 0.5438583400358707 1.493498639985595 0.135306709993588 1.0 0.6146522074014283 13 P40855,Q13423,O75381 3 +Polar cataract 0.933209071140104 1.489550060510981 0.136342581271283 1.0 0.6179128662293514 2 Q7LGA3 1 +Prematurely aged appearance 0.4439740266415689 1.4892204355129168 0.1364293312421651 1.0 0.6179128662293514 40 O75844,P02545,Q6NUK1,Q9Y4P3,O14656,Q03252,Q9Y487,Q13126,O75431 9 +Clonus 0.4564089048076742 1.488151643199506 0.1367109066398573 1.0 0.6183944839809895 33 O00400,P07602,P20700,Q9BQT8,Q9NZJ7,Q15043,Q9NW15,Q12768,O75298,Q99720,Q9Y619 11 +Sclerosis of hand bone 0.9325877601739636 1.4870042909983052 0.1370136776394144 1.0 0.6183944839809895 2 P02545 1 +Abnormal form of the vertebral bodies 0.389269043155905 1.484137096811629 0.1377725534280927 1.0 0.6183944839809895 88 P34059,Q15427,P54802,Q9UHX1,Q10713,Q9UM00,P10644,O00754,P16278,Q6NUK1,Q9Y4P3,Q96L58,O96028,Q12768,P51798,Q9UBM7,Q04656,Q01968,O95202,P16435,Q5JRA6,O95831,Q96DX4,Q8TAA9,P51812,Q15056,Q53GS7,Q15125,Q14739,Q96HY6,Q96AY3,Q04721,P15586,P07237,Q9Y2Q9,O15228,Q5H8A4,Q6NUQ1,Q9Y619 39 +Wide anterior fontanel 0.4801435682991976 1.4824376050524963 0.1382238941924167 1.0 0.6183944839809895 21 P16435,P20674,Q6NUK1,Q16134,Q9Y487,P40855,Q15125,O75381 8 +Poor wound healing 0.6958090042473082 1.4819736298764123 0.1383473116981179 1.0 0.6183944839809895 5 P04062 1 +Abnormal leukocyte physiology 0.367994331416555 1.480886808557391 0.1386367387983491 1.0 0.6183944839809895 64 P02545,P09601,Q9UJS0,P04637,Q15904,P04062,Q14108,P21964,O00203 9 +Multicystic kidney dysplasia 0.4929036460650526 1.4800809233839032 0.1388516518872238 1.0 0.6183944839809895 19 Q96J42,O75381,Q10713,P40855,Q15645,Q9UBM7,O60566 7 +Abnormal urine protein level 0.3838486291956491 1.4798933274478303 0.1389017166827515 1.0 0.6183944839809895 60 Q5JRA6,P09601,Q14108,Q9Y4P3,P00403,Q03252,P06280,P04062,Q8NFH4,P03886,O95470,O75431,P35670 13 +Abnormal aortic arch morphology 0.5537593761321702 1.479808401411849 0.1389243859483793 1.0 0.6183944839809895 12 Q9UHX1 1 +Abnormal shoulder physiology 0.9245278487149018 1.4791447953724095 0.1391016201136534 1.0 0.6183944839809895 3 O75844 1 +Hypertriglyceridemia 0.4648130087900741 1.4769608283641582 0.1396861378097633 1.0 0.6197895591384752 24 P02545,P22830,Q9UJS0,P50402,P35573,Q8WXH0,P28070,P31751,O95470,O75431 10 +Foam cells 0.6939109878975205 1.4733589924291706 0.1406542615199231 1.0 0.6232863734886672 5 P16278,Q13510,O15118 3 +Esophageal varix 0.6622731921228626 1.4730169133977211 0.1407464752538287 1.0 0.6232863734886672 6 P35670 1 +Abnormality of female external genitalia 0.4559249852170656 1.4722420930426543 0.1409555142987415 1.0 0.6236089854820652 32 P16435,P10644,P02545,Q6NUK1,Q15392,P53701,P40855,O75381,Q9Y619 9 +Focal segmental glomerulosclerosis 0.4717494099231619 1.4709829981909426 0.1412957148676643 1.0 0.624510693416057 22 Q14108,P00403,P03886,O95470,O75431 5 +Congenital hepatic fibrosis 0.6615579595141727 1.4695791333099109 0.1416757751500421 1.0 0.6252495501837451 6 Q96J42 1 +Abnormal renal tubule morphology 0.4642689720074565 1.4677803203816475 0.1421639047651686 1.0 0.6259312691535645 23 P06280,Q9Y4P3,O43819,O75306,P03886,P23786,Q86YH6,Q01968 8 +Intestinal malrotation 0.4577849863148741 1.4662603394384988 0.1425773758195183 1.0 0.6260126928070794 30 Q15392,Q8NCH0,Q12768,P21964,Q14739,O95202 6 +Short upper lip 0.7893462528445369 1.4662046596830565 0.1425925395496361 1.0 0.6260126928070794 4 O95202 1 +Diastasis recti 0.7885701215724517 1.4629951457459691 0.1434687072264391 1.0 0.628266701569301 4 Q8NCH0 1 +Abnormality of the musculature of the upper arm 0.6111554026289329 1.4615794780579356 0.1438564814275229 1.0 0.628266701569301 8 P50402,Q8WXH0,P02545,O14979 4 +Proximal upper limb amyotrophy 0.6111554026289329 1.4615794780579356 0.1438564814275229 1.0 0.628266701569301 8 P50402,Q8WXH0,P02545,O14979 4 +Hyporeflexia 0.4172710226891152 1.4609224902460052 0.1440367137890277 1.0 0.628266701569301 118 Q9HC21,O43681,P07196,P54802,O75787,O15269,Q10713,P53007,P05023,P03886,P40939,Q6UWE0,Q96RL7,P07602,P39210,Q04656,P02545,O95831,Q9NR77,P57678,Q8TB36,Q8TD16,P04062,Q99720,Q9UBB4,O95140,Q9NZJ7,P12235,Q5H8A4 29 +Vocal cord paresis 0.7878699890927927 1.460099564182442 0.1442627123897932 1.0 0.628266701569301 4 Q8TB36 1 +Skin pit 0.5132481258281612 1.4593423159394323 0.1444709140629878 1.0 0.628266701569301 15 O96028,Q99828,P16615,O95202 4 +Gastric ulcer 0.9189285373912494 1.4575632634868163 0.1449609617455085 1.0 0.628266701569301 3 P04062 1 +Progressive peripheral neuropathy 0.9188937228091928 1.4574290569445811 0.1449979811082433 1.0 0.628266701569301 3 P07602,Q9NZJ7 2 +Vegetative state 0.9188937228091928 1.4574290569445811 0.1449979811082433 1.0 0.628266701569301 3 P07602,Q9NZJ7 2 +Mitochondrial inheritance 0.7870788806668342 1.4568273406729462 0.1451640467919459 1.0 0.628266701569301 4 P03886,P00403 2 +Spastic diplegia 0.4604145447345633 1.4482192734791484 0.1475557360155897 1.0 0.6349620723624202 25 Q99720,P07602,P51648 3 +Leukoencephalopathy 0.3923513097631602 1.4467558327351333 0.1479653209340869 1.0 0.6349889452269769 94 O60313,Q9H9P8,O43681,Q9UHX1,P03886,O43676,P07602,P17900,Q96CU9,O96028,Q86Y39,O95202,O95831,Q01105,P20700,O00584,O96000,O75503,Q9Y6M9,P51571,Q13144,Q9NZJ7 22 +Atrial arrhythmia 0.5721263246504669 1.4461836735598577 0.1481256917158075 1.0 0.6350819685081301 10 P50402,P02545 2 +Mitochondrial respiratory chain defects 0.6875575183782318 1.444489938851767 0.1486012078402887 1.0 0.6365247246966157 5 O75306,P03886,O75648 3 +Hyperglycemia 0.607354490687827 1.4415580508344448 0.1494270897353917 1.0 0.6393124320689836 8 O75844 1 +Breast aplasia 0.9214041627834688 1.4411891436760904 0.1495312545852547 1.0 0.6393124320689836 2 P02545 1 +Pulmonary hypoplasia 0.4564879652146809 1.4379424060534636 0.1504503962587968 1.0 0.6414454045335483 28 O75844,P02545,Q6NUK1,O43175,Q16134,Q69YQ0,Q96L58,Q8TAA9,O96000,Q53GS7,Q99567,Q9UBM7,Q14739 13 +Nemaline bodies 0.7823263473814297 1.437161323648247 0.1506721597921521 1.0 0.641793320640246 4 O43676 1 +Narrow mouth 0.3699473389700428 1.4338822025129183 0.1516058815363041 1.0 0.6422507164906595 74 P16435,O75844,P02545,Q9NVI7,Q6NUK1,Q15392,Q9NX62,Q8NCH0,P04062,Q7LGA3,Q9Y487,Q9Y619,O75431,P21964 14 +Deep palmar crease 0.5581893632507975 1.4338288788041156 0.1516211016655171 1.0 0.6422507164906595 11 Q9Y487,O75431,Q6NUK1 3 +Waddling gait 0.4583933629035758 1.4323430045531125 0.1520456813430026 1.0 0.6434223723818541 25 P02545,P07196,P50402,Q8TD16,Q13510,Q8WXH0,P53007,Q5T8D3 8 +Premature skin wrinkling 0.4861251124188759 1.4318780140824627 0.152178735376621 1.0 0.6434223723818541 19 O75844,Q9Y487,P02545,Q6NUK1 4 +Abnormality of the knee 0.3877025871181385 1.4285359740544885 0.1531376478454178 1.0 0.6459513158446891 91 P34059,Q13509,Q9NX62,Q86XL3,Q7LGA3,Q96PU5,O00754,P16278,O75477,Q9Y4P3,Q96L58,O14656,Q13510,P48651,P51798,Q04656,Q01968,Q5JRA6,O95831,Q9NR77,P36543,Q8TD16,Q96DX4,Q15041,Q15125,O75431,P23786,P21912,Q96HY6,Q96AY3,P37268,O94905,Q969X5,Q9Y619,P21964 35 +Ectopia pupillae 0.7799081058677364 1.42714938856036 0.1535368392027651 1.0 0.6459513158446891 4 O95202 1 +Rieger anomaly 0.7799081058677364 1.42714938856036 0.1535368392027651 1.0 0.6459513158446891 4 O95202 1 +Preaxial foot polydactyly 0.7799081058677364 1.42714938856036 0.1535368392027651 1.0 0.6459513158446891 4 O95202 1 +Abnormal iliac wing morphology 0.5447734466285105 1.4257633313671232 0.1539366687404968 1.0 0.6466752350116834 12 P16278,O95831,Q96L58,Q8TAA9,P51812,Q04656 6 +Postaxial hand polydactyly 0.5446655067655505 1.4251127472849854 0.1541246124331641 1.0 0.646871311027918 12 Q96J42,Q9Y263,Q10713,Q9UBM7,Q14739 5 +Tetraparesis 0.4501545857315558 1.424506303918306 0.1542999615461013 1.0 0.6470073668689031 32 Q9H9P8,P20700,P07602,P17900,Q9UBX3,Q9Y296,Q9NZJ7,P21912 8 +Short chin 0.5681918602135246 1.4238110781919442 0.1545011679484171 1.0 0.6470073668689031 10 O75844,P02545 2 +Leukodystrophy 0.3996648827003722 1.4229258762555448 0.1547576440696267 1.0 0.6471554814564575 54 Q9P0J0,P07602,P20700,O43681,Q96CU9,Q7KZN9,O95299,Q9NZJ7,O96000,O43819,Q86Y39,Q9Y6M9,P03886,O43676 14 +Impaired tactile sensation 0.5791549564325673 1.4213921214711318 0.1552027956053876 1.0 0.6478337293318779 9 P39210,O15269 2 +Overtubulated long bones 0.9078026481391362 1.414665046184493 0.1571667274199657 1.0 0.6536479971444351 3 O75844 1 +Protruding tongue 0.5542855673992674 1.4109722399115017 0.1582527995428926 1.0 0.6559745158514128 11 Q6NUK1,Q10713,Q96RL7 3 +Abnormality of circulating leptin level 0.7753175879881589 1.40813487126536 0.1590911370176808 1.0 0.6559745158514128 4 O75844 1 +Muscle fiber atrophy 0.4565649454809946 1.4080747492730388 0.1591089371300929 1.0 0.6559745158514128 23 P02545,P50402,Q99720,P23786,Q96RL7 5 +Contractures of the joints of the upper limbs 0.3666094956965439 1.407120068035926 0.1593917883271285 1.0 0.6559745158514128 73 P07196,Q15392,Q13509,Q7LGA3,O43175,P50402,P42892,Q8IZA0,O14656,Q96L58,P48651,P16435,O75844,P02545,Q9NR77,Q8WXH0,Q99720,P23786,Q96AY3,P37268,O94905,Q969X5,Q9Y619 23 +Visual loss 0.4101386210322284 1.4055192078212069 0.1598669417216331 1.0 0.6559745158514128 50 O60313,P50148,P50897,P07602,O95140,P04439,O75306,Q9NZJ7,P00403,O14773,O75503,P53701,Q10713,O15460,P03886,P40939,P51798 17 +Enlarged thorax 0.517457701485899 1.404907138975206 0.1600488934459478 1.0 0.6559745158514128 14 O75844,P02545 2 +Hypoplastic vertebral bodies 0.6243580960286438 1.404715348013651 0.1601059399828117 1.0 0.6559745158514128 7 P10644,P16278,Q14739,Q8TAA9 4 +Absent septum pellucidum 0.4463753047497132 1.4044576840670997 0.1601826040576071 1.0 0.6559745158514128 33 Q9UBB6,O43175,Q15392,Q96N66,O96028,P53701,P55011,P51571,P48651,Q9NZ01,O95202 11 +Increased c peptide level 0.9117738428083224 1.4017602370137905 0.160986856041077 1.0 0.6570567784698214 2 P40939 1 +Congenital contracture 0.4179602176627195 1.401717183432442 0.1609997172839352 1.0 0.6570567784698214 47 Q8NBU5,Q15392,Q9UPT5,Q96AA3,P53007,Q99567,O43175,O14656,O75844,P02545,Q8TD16,P04062,Q53GS7,Q96AY3,Q8NCH0,Q96S52,Q96A33,Q969X5,Q53EZ4 19 +Micrographia 0.9114631873252516 1.400488846941235 0.1613669809275546 1.0 0.6579691947170727 2 P04062 1 +Ectopic anus 0.5162747807451901 1.3973205531616235 0.1623171978992554 1.0 0.6600916944767256 14 P16435,Q12768,P53701,Q6NUK1 4 +Abnormality of the intrahepatic bile duct 0.9033026838774164 1.397311254150992 0.1623199930073799 1.0 0.6600916944767256 3 P02545 1 +Slender long bone 0.5037532299957552 1.3966111917590096 0.1625305229314328 1.0 0.6603613704552185 15 P37268,Q53GS7,Q96DX4,Q96L58,Q9Y487,Q9H490,Q9Y619 7 +Respiratory failure 0.3724585649250696 1.3944682219062066 0.1631762592336925 1.0 0.6620784560840838 61 Q15165,P07602,Q5XKP0,Q9BT22,Q70HW3,Q8TD16,Q9NZJ7,P10253,P61916,Q13510,P53701,O43819,P40939,P23786,Q9Y619 15 +Impaired social interactions 0.417034570767641 1.392869477119271 0.1636592639454686 1.0 0.6620784560840838 47 Q9P0J0,Q5XKP0,O75746,Q96CU9,Q5KU26,O96000,Q9UHX1,Q86Y39,P53007,Q9Y6M9,P03886,O43676 12 +Vascular tortuosity 0.901802361715348 1.391525238683399 0.1640662117322926 1.0 0.6620784560840838 3 P05067,P03886 2 +Lagopthalmos 0.9016959406709244 1.3911148238119588 0.1641906103998009 1.0 0.6620784560840838 3 O75844 1 +Dysesthesia 0.6449694621342775 1.389638354656295 0.1646387227635761 1.0 0.6620784560840838 6 Q8NCH0 1 +Scaling skin 0.5974360092224706 1.3891820085484892 0.1647774111870057 1.0 0.6620784560840838 8 O75844 1 +Equinovarus deformity 0.6448246145117167 1.388938671012186 0.1648513999961269 1.0 0.6620784560840838 6 P40939,Q96RL7,Q9NR77 3 +Falls 0.5730853068090344 1.3877383952893938 0.1652167198712852 1.0 0.6620784560840838 9 Q9BQT8,P21912,Q96RL7,O75787 4 +Shallow orbits 0.5969683514099977 1.3867080174016837 0.1655308148660794 1.0 0.6620784560840838 8 O75844,P02545 2 +Abnormal delivery 0.4600116415180456 1.3819106103994947 0.1669991496400524 1.0 0.6628814406914094 22 O60313,O75844,P02545,Q9Y487,Q9UBM7,Q9Y619 6 +Abnormality of the alveolar ridges 0.6737698124469018 1.3816832139866506 0.1670689907010034 1.0 0.6628814406914094 5 Q15392,Q9UBM7 2 +Long toe 0.5605459696739157 1.3802302183051 0.1675157726620362 1.0 0.6635421479407126 10 P10644,Q9UHX1,P23786 3 +Intestinal pseudo obstruction 0.5369588558742662 1.3785807696439696 0.1680240490434716 1.0 0.6646377388433192 12 Q5HYI8,P03886,P04637,P00403 4 +Thickened ribs 0.768106931924133 1.3782460696131538 0.1681273277863137 1.0 0.6646377388433192 4 P16278,O00754,P54802 3 +Inability to walk 0.3771416173032572 1.3779205824235885 0.1682278094167737 1.0 0.6646377388433192 85 O14949,Q9NVI7,P07196,Q96N66,O75787,O15269,Q96RL7,Q96CU9,Q13510,Q9NR77,P57678,Q8TB36,Q15043,O75503,Q15041,Q99720,P21912,O95140,P52788,P12235 20 +Abnormality of chorioretinal pigmentation 0.7674891507359165 1.375684224811633 0.1689194179969191 1.0 0.6662737369038778 4 Q5XKP0 1 +Vitiligo 0.6185755078886785 1.3755112639147635 0.1689729960544914 1.0 0.6662737369038778 7 P03886 1 +Congenital hypothyroidism 0.7673271956399889 1.3750125953768972 0.1691275398606706 1.0 0.6662737369038778 4 Q13423,P10644 2 +Lack of skin elasticity 0.5124575668471348 1.3728096599643107 0.1698115268950839 1.0 0.6662737369038778 14 O75844,P02545,O43175,P04637 4 +Undetectable electroretinogram 0.7664091176619903 1.3712051142959798 0.1703110243634025 1.0 0.6662737369038778 4 P50897,Q96S66 2 +Abnormal intraocular pressure 0.617505384733211 1.37010128725892 0.1706552860685106 1.0 0.6662737369038778 7 P04439,Q8NCH0,Q15043 3 +Sea blue histiocytosis 0.895898073337477 1.368755631071204 0.1710756742835957 1.0 0.6662737369038778 3 P16278,O15118 2 +Sideroblastic anemia 0.5696032839518852 1.368397174031813 0.1711877883480579 1.0 0.6662737369038778 9 P38398,O76024,Q9BXW9 3 +Delayed fine motor development 0.5695892555835775 1.3683192023304147 0.171212182722261 1.0 0.6662737369038778 9 P16435,Q5KU26,Q13509,P51798 4 +Abnormal metatarsal morphology 0.4501655408022887 1.3674915416417557 0.1714712866879175 1.0 0.6662737369038778 25 P16435,P10644,Q15392,Q13509,Q03252,O96028,Q96L58,Q96S52,Q9UBM7,O43505,O95202 11 +Rhizomelia 0.5349803755465923 1.3666095639508196 0.171747717850633 1.0 0.6662737369038778 12 Q15392,Q15125,Q14739,O00116 4 +Hypokinesia 0.5114592622416851 1.3663921078949834 0.1718159245758193 1.0 0.6662737369038778 14 O95831,P04062,P13473,P12235,Q2TAA5 5 +Status epilepticus 0.4213378765980785 1.364078929538839 0.172542725493199 1.0 0.6667739244086287 44 Q9UBB4,P07602,Q01105,Q15392,P42892,Q9NZJ7,Q03252,Q13510,P53701,Q9Y487,P05023 11 +Cutis laxa 0.4440957149478838 1.3638732211255118 0.1726074702666626 1.0 0.6667739244086287 31 Q6NUK1,P38435,Q8NCH0,Q15904,Q9Y4P3,O96000,O75787,Q9Y487,P48651,Q04656 10 +Low frustration tolerance 0.5685482164033038 1.3625318571560014 0.1730300974356886 1.0 0.6667739244086287 9 Q9UHX1 1 +Abnormal urine carbohydrate level 0.5460146113504631 1.3624208351736116 0.1730651120656174 1.0 0.6667739244086287 11 O00754,P16278,Q9UJS0,P04637,P10253 5 +Narrow nasal ridge 0.5923344436714438 1.3621732175954202 0.1731432259320389 1.0 0.6667739244086287 8 O75844,P02545 2 +Poor suck 0.4460875726321482 1.3620490304816284 0.1731824121342811 1.0 0.6667739244086287 29 Q9Y263,O75648,Q15233,O43819,P53007,P22695,P40939,O75962,Q9UBM7,Q04656,Q12959 11 +Inverted nipples 0.5920755719228343 1.3608015052975213 0.1735764260933421 1.0 0.6667739244086287 8 P61978,Q96AA3,P56589,Q2TAA5 4 +Short clavicles 0.5680947733221396 1.360010401964623 0.1738266322201094 1.0 0.6667739244086287 9 O75844,P02545,Q04656 3 +Flat face 0.4501370188853184 1.3580254206965876 0.1744556180327705 1.0 0.6667739244086287 23 O00754,Q9NX62,Q96L58,Q9Y487,P56589,Q15555,P40855,Q9UM00,Q15125,O75381 10 +Distal lower limb amyotrophy 0.5334376012375608 1.357267738125752 0.1746961543477974 1.0 0.6667739244086287 12 P07196,P02545,Q8TD16,Q9NR77 4 +Gastrointestinal hemorrhage 0.4441699893738783 1.3550393749320746 0.1754050123217323 1.0 0.6667739244086287 30 Q9UJS0,Q9NZ08,Q14739,Q9UHX1,P21964,P21912,Q04656,O76024 8 +Difficulty walking 0.3620989725465054 1.3529187236500102 0.17608159705997 1.0 0.6667739244086287 73 Q9HC21,P07602,Q15041,O43681,Q9NR77,O95140,Q8TD16,P51530,Q9NZJ7,Q13510,Q12768,P53007,O75298,Q99720,Q9BPX6,P35670 16 +Head titubation 0.6139531803568982 1.3521314401212512 0.1763332711782004 1.0 0.6667739244086287 7 Q99720,Q96RL7 2 +Pneumothorax 0.6371153799832511 1.3516617420360786 0.1764835491275076 1.0 0.6667739244086287 6 Q8NCH0,Q6NUK1,Q96L58 3 +Pseudoepiphyses of the metacarpals 0.7616169219124193 1.3513255458680986 0.1765911722953745 1.0 0.6667739244086287 4 O96028,O95202 2 +Abnormality of the calf musculature 0.5089061236539492 1.3499659277078326 0.1770269123813415 1.0 0.6667739244086287 14 P02545,Q12768,Q96RL7,Q9NR77 4 +Distal lower limb muscle weakness 0.4860434170553936 1.3493345587076098 0.1772295301415736 1.0 0.6667739244086287 17 Q00796,P02545,Q9NR77,O95140,P07196,P53007 6 +Quadriceps muscle weakness 0.6666251107448036 1.349061402894505 0.1773172443090018 1.0 0.6667739244086287 5 P12235 1 +Nuclear cataract 0.666610374631722 1.3489940715942388 0.1773388703014169 1.0 0.6667739244086287 5 P08670,O76024 2 +Hypertrophic nerve changes 0.8987263125194129 1.3483988875115769 0.1775301216076741 1.0 0.6667739244086287 2 Q8TB36 1 +Aplasia involving bones of the lower limbs 0.8905928649985687 1.3482983564105064 0.1775624405590328 1.0 0.6667739244086287 3 P02545 1 +Abnormal connection of the cardiac segments 0.3984457350626473 1.3468957345893104 0.1780138154822026 1.0 0.6667739244086287 52 O75844,P02545,O43175,Q9Y4P3,Q9UHX1,P40855,P21964 7 +Adult onset 0.3526222969217642 1.346139370880144 0.1782575735636773 1.0 0.6667739244086287 65 P02545,P07602,P20700,P38435,O14979,Q9NZJ7,P04062,Q8IV08,Q12768,P12235,P21912,O15118,O76024 13 +Postaxial polydactyly 0.4484998465656294 1.3452452344221129 0.178546052822097 1.0 0.6667739244086287 23 Q96J42,Q9Y263,Q10713,Q9UM00,Q15125,Q9UBM7,Q14739 7 +Abnormal midbrain morphology 0.6656557539280771 1.34463187799666 0.1787441435230579 1.0 0.6667739244086287 5 P04062 1 +Progressive hearing impairment 0.5080638178000687 1.3445425815145409 0.1787729965045306 1.0 0.6667739244086287 14 P03886,O76024,P00403 3 +Periventricular cysts 0.6123723684208625 1.3441287777410895 0.178906747700511 1.0 0.6667739244086287 7 O95202 1 +Brushfield spots 0.7594644798413032 1.3423939344218938 0.1794683003834953 1.0 0.6667739244086287 4 P40855,O75381 2 +Paraparesis 0.4453797740822298 1.341378262050559 0.1797976716678797 1.0 0.6667739244086287 27 Q5XKP0,P04062,O75787,Q13510,Q9Y619,Q9H6K4 6 +Turricephaly 0.542399421782102 1.3411483274756766 0.1798722992257617 1.0 0.6667739244086287 11 Q6NUK1,P21964 2 +Corneal erosion 0.6646908259557393 1.3402217894842725 0.1801732496395827 1.0 0.6667739244086287 5 P51648 1 +Peptic ulcer 0.5421828767172504 1.3398731871099436 0.1802865765846206 1.0 0.6667739244086287 11 P04062,Q9Y4P3 2 +Severe postnatal growth retardation 0.5304216861498912 1.3389885104258734 0.1805744133185929 1.0 0.6667739244086287 12 O76024,O95202 2 +Visual field defect 0.4208513076256831 1.338742666172568 0.1806544613091172 1.0 0.6667739244086287 43 O60313,P50148,Q8WWV3,O15460,O95140,P04439,O75306,Q9H061,P00403,P56589,Q15555,P40855,P03886,O75381,Q9H6K4 15 +Osteolysis 0.445651804013745 1.3372811575205903 0.181130879148988 1.0 0.6667739244086287 26 O75844,P02545,P04062,Q15645,Q14108,O75431,Q04656 7 +Cholecystitis 0.5876140710655555 1.337143476498279 0.1811758079858401 1.0 0.6667739244086287 8 P07602,Q9NZJ7 2 +Abnormal endocrine physiology 0.6637732404040351 1.3360273453388516 0.1815403355134794 1.0 0.6667739244086287 5 Q13423 1 +Severe muscular hypotonia 0.442788114212796 1.335164426158331 0.1818225370612052 1.0 0.6667739244086287 29 Q9NWM8,P02545,O95831,Q01105,Q8TD16,P53007,P40855,Q5H8A4,O75381 9 +Muscle hypertrophy of the lower extremities 0.6103488451232779 1.3338800084991356 0.1822431843286183 1.0 0.6669915211792083 7 P02545,Q9NR77 2 +Chorioretinal dysplasia 0.7572272303388232 1.3331089196091093 0.1824960626886149 1.0 0.6669915211792083 4 P53701,O43505,Q01968 3 +Kinetic tremor 0.4377115151677634 1.3317188169398255 0.1829526035644288 1.0 0.6680424823439359 33 P07602,P20700,O43681,Q9NZJ7,Q9NW15,Q14108 6 +Osteopenia 0.3614010481044936 1.3312848959275103 0.1830952861632757 1.0 0.6680424823439359 74 O75844,P10644,P02545,Q5JRA6,P07602,O43175,Q9NWM8,Q9Y4P3,Q9NZJ7,P04062,Q9Y487,Q13126,Q14108,O75431,Q04656 15 +Bradycardia 0.5406291493104799 1.330720883719536 0.183280868789605 1.0 0.6681871800856699 11 O75880,P02545,O75208 3 +Chorioretinal coloboma 0.6320617622785649 1.327187906982118 0.1844465316887369 1.0 0.6692387202580965 6 Q12768 1 +Abnormal atrioventricular valve physiology 0.40216593400449 1.326536968712686 0.1846618982494201 1.0 0.6692387202580965 50 O43819,P40939,P10644,O00754,Q6NUK1,Q9Y4P3,P06280,Q96L58,O75844,P02545,Q9NZ08,P36543,Q96DX4,P04062,P51812,Q15056,O75431,Q15904,Q15233,P53701,O75306 21 +Abnormality of abdominal situs 0.6616470457521344 1.3263054783953794 0.184738532956155 1.0 0.6692387202580965 5 Q5H8A4,O95202 2 +Hypoplastic pubic rami 0.6616470457521344 1.3263054783953794 0.184738532956155 1.0 0.6692387202580965 5 Q5H8A4,O95202 2 +Rib segmentation abnormalities 0.6616470457521344 1.3263054783953794 0.184738532956155 1.0 0.6692387202580965 5 Q5H8A4,O95202 2 +Abnormal protein o linked glycosylation 0.754575511303283 1.3221020231218323 0.1861341802067457 1.0 0.6718213036376404 4 Q8N511 1 +Elevated circulating long chain fatty acid concentration 0.8922025473749563 1.321753276092389 0.1862503216876767 1.0 0.6718213036376404 2 P40855 1 +Acne 0.4924452332237438 1.3215088789274916 0.1863317439658884 1.0 0.6718213036376404 15 Q92542,P21964 2 +Aplasia hypoplasia of the pubic bone 0.6305709095016497 1.3199626415585537 0.1868474913098858 1.0 0.6726215901792196 6 Q5H8A4,O95202 2 +Atrophy degeneration involving the spinal cord 0.5607884263766358 1.319327462831501 0.1870596603990459 1.0 0.6728563903905982 9 Q8IY17,P20700,P07196 3 +Primitive reflex 0.6073589435846412 1.318726883337242 0.1872604358912677 1.0 0.6730498712292896 7 P17900 1 +Abnormal conjunctiva morphology 0.4405056524578679 1.3165335255228685 0.1879950335999625 1.0 0.6735753199172365 29 Q9NZ08,P06280,Q99643,Q9NW15,Q13510,P10619,P21912,Q14739 8 +Abnormal clavicle morphology 0.463910285408724 1.3155551386939388 0.1883233991458353 1.0 0.6742242726260984 20 O75844,Q04656,P02545,Q9Y619,O75431,Q14739 6 +Meningitis 0.6291649085745175 1.3131464825122343 0.1891335934224416 1.0 0.6749394392178046 6 Q9NZ08,P49327,O15460,Q8TAA9 4 +Limited hip movement 0.4858855400782841 1.311646447796314 0.1896394534496639 1.0 0.6749394392178046 16 O75844,P02545,Q96AY3,Q8TD16,O94905,Q7LGA3 6 +Abnormal peripheral action potential amplitude 0.5483290386637915 1.3103296765417802 0.1900843322336833 1.0 0.6749394392178046 10 O15269,Q96RL7 2 +Saccadic smooth pursuit 0.6284574341410509 1.3097159522804882 0.190291944972742 1.0 0.6749394392178046 6 Q9NW15,O14773,Q10713 3 +Abnormal brain lactate level by mrs 0.5476489468850794 1.3064295439341695 0.1914065243466163 1.0 0.6778987552458898 10 P03886,O43819,P21912,P00403 4 +Osteolysis involving bones of the upper limbs 0.5818219913358351 1.3063828862141598 0.1914223827326786 1.0 0.6778987552458898 8 O75844,P02545 2 +Abnormal circulating dehydroepiandrosterone concentration 0.8878533706119841 1.3040057014927342 0.1922316384170237 1.0 0.6792000506608218 2 Q13423 1 +Supernumerary bones of the axial skeleton 0.6566784838200095 1.3035734003780015 0.1923790748951899 1.0 0.6792000506608218 5 Q9UHX1 1 +Stroke 0.4343709358312354 1.303561441158544 0.1923831547733316 1.0 0.6792000506608218 33 O75844,P02545,Q96AA3,P06280,Q9Y4P3,P00403,P05067,P03886,O76024 9 +Ovoid vertebral bodies 0.5576609807411397 1.3018832219604586 0.1929563088077974 1.0 0.6804149589120099 9 P16278,P34059,Q96L58,P54802 4 +Aplasia hypoplasia involving the pelvis 0.4791470410649383 1.301683897477316 0.1930244663958726 1.0 0.6804149589120099 17 Q96HY6,O95831,O96028,Q5H8A4,O75431,O95202 6 +Reduced visual acuity 0.4035454753135602 1.3001695730322418 0.1935428565934773 1.0 0.6811934975722773 118 O60313,O43681,Q9H061,Q96AA3,P09622,Q9UHX1,P06865,Q10713,P03886,O43676,P16278,P50897,P07602,P17900,Q96CU9,Q86Y39,P51798,Q9NZ08,Q15043,O96000,Q9Y6M9,P21912,Q9H6K4,Q8WWV3,Q9NZJ7,P53701,Q96S66,O75962,O00203 29 +Fatigue 0.3683209191392053 1.297782681816706 0.1943620222844675 1.0 0.6834658510013429 83 O60313,Q5HYI8,P10644,P07602,P06280,P50416,O15460,Q13423,Q04656,Q15165,Q9NZ08,Q70HW3,P04062,P21912,Q14739,P04637,Q9NZJ7,Q53H12,P12235 19 +Limited elbow movement 0.4258380239447756 1.2953724918547502 0.1951917627324717 1.0 0.6834658510013429 38 P16435,P02545,Q15427,P50402,Q96AY3,P37268,O14656,Q96L58,O94905,Q7LGA3,Q8WXH0,Q969X5,Q9H6K4,P48651,P23786,Q8WVM7,Q04656 17 +Bilateral tonic clonic seizure with focal onset 0.8762879804869783 1.2931621612048323 0.1959549796047666 1.0 0.6834658510013429 3 P07602 1 +Microretrognathia 0.4724453867713883 1.293132169534811 0.1959653506055887 1.0 0.6834658510013429 18 Q15125,Q8NCH0,Q9UHX1 3 +Papule 0.4547187320162784 1.2930011066314968 0.1960106763585274 1.0 0.6834658510013429 21 O75844,P02545,P38435,Q9NZ08,Q99643,Q99828,P21912,P16615 8 +Mandibular aplasia 0.8850574712643651 1.2926041827647698 0.1961479922163227 1.0 0.6834658510013429 2 Q9Y619 1 +Broad ribs 0.654156611433784 1.2920285535415323 0.1963472564203665 1.0 0.6834658510013429 5 P16278,Q04656 2 +Macular purpura 0.4829673955121067 1.2918270872932145 0.1964170325359167 1.0 0.6834658510013429 16 P04062,Q8NCH0,P38435 3 +Decreased plasma carnitine 0.5340087884347273 1.2916647943072874 0.1964732545346685 1.0 0.6834658510013429 11 O75880,P09622,P40939,P23786,Q16836 5 +Short palm 0.4404154158831556 1.2901995184534858 0.1969813933102897 1.0 0.6834658510013429 25 P10644,P02545,Q9UHX1,Q9Y619,O75962,Q04656 6 +Pigmentary retinopathy 0.4111015227882807 1.289883015789176 0.1970912786080676 1.0 0.6834658510013429 45 Q9P0J0,Q9UG56,Q96CU9,Q7KZN9,P00403,O95299,P53701,Q96S66,P03886,P40939,Q16836,O76024 12 +Acute hepatic failure 0.4772981213287778 1.2888818551179029 0.1974391630703778 1.0 0.6834658510013429 17 P40939,P08574,P39210,Q16836,P35670 5 +Malabsorption 0.3925900795241727 1.2872927322192618 0.197992275774451 1.0 0.6841002387217342 52 P09601,P06280,Q9Y4P3,Q96A33,P40855,O75381,Q14739,Q04656,O76024 9 +Severe lactic acidosis 0.7461147332617117 1.2869729509905463 0.1981037162142431 1.0 0.6841002387217342 4 Q70HW3,O75648 2 +Elevated hepatic transaminase 0.390476415019609 1.2819501230222057 0.199860143379166 1.0 0.687284530782524 106 Q5HYI8,O75787,P09622,Q10713,P40855,P22695,P40939,Q16836,Q96RL7,P39210,Q13510,P50416,P35670,P35573,O75431,P23786,Q14739,Q8N511,Q5XKP0,Q9UJS0,P04637,Q15904,P10253,O75880,P38398,P12235,Q9Y619,Q2TAA5 28 +Abnormal diaphysis morphology 0.3516982375057846 1.2805945697191947 0.2003361083569146 1.0 0.687284530782524 69 P34059,Q13509,Q9NX62,Q7LGA3,O00754,P16278,Q9Y4P3,Q96L58,P48651,P51798,Q04656,Q01968,P16435,Q96J42,Q9NR77,Q96DX4,P51812,Q15056,O75431,Q14739,Q96HY6,Q96AY3,Q04721,P07237,Q9Y487,Q13126,Q9Y619 27 +Anorexia 0.4384867802956951 1.2799924588795288 0.2005477880949973 1.0 0.687284530782524 26 P10644,O15460,Q9NZ08,P04637,P06280,Q5HYI8,P04062,Q13423,Q14108 9 +Abnormal ureter morphology 0.4377243960385074 1.279737406811441 0.2006375041051624 1.0 0.687284530782524 27 O75844,P02545,Q96J42,Q9BXW9,P38398,Q7LGA3,P23786,O76024 8 +Pes valgus 0.5319849066516669 1.2797069879301464 0.2006482060737746 1.0 0.687284530782524 11 Q5H8A4,Q9UHX1,Q96AA3 3 +Thickened skin 0.388062859362215 1.2766682914002965 0.201719380584969 1.0 0.6889407961216714 104 O15269,Q15800,P40855,P16615,P16278,P98194,O43175,P50402,P06280,P51648,O95470,Q04656,O75844,P02545,P04062,Q15125,O75431,Q14739,Q06136,O75381,P42167 21 +Patchy alopecia 0.8719113799673474 1.276304658933515 0.2018478439081754 1.0 0.6889407961216714 3 O75844 1 +Lower limb hypertonia 0.5310901764384482 1.274418014101357 0.202515311461831 1.0 0.6894554729990513 11 Q8WVX9,O00400,Q9ULH0,P21912,Q14739 5 +Chorioretinal atrophy 0.7425280001040953 1.2720780716910758 0.2033453815134369 1.0 0.6898390692930103 4 P40939 1 +Abnormality of corneal stroma 0.4850193901073603 1.271977116546394 0.2033812499553535 1.0 0.6898390692930103 15 P04062,Q13510,P10619 3 +Motor seizure 0.3865726976539498 1.2707172690536628 0.2038292497620348 1.0 0.6902685033872379 103 Q96N66,O75787,P55011,P03886,Q9NZ01,P16278,P07602,O43175,Q9Y320,Q13510,Q01105,P13073,P04062,O75503,P21912,Q9UBB4,Q8WWV3,Q5XKP0,Q9UBX3,P52788,Q9NZJ7,Q9Y619 22 +Unilateral renal agenesis 0.4389380635342256 1.2703496853479828 0.2039600972009025 1.0 0.6902685033872379 23 P16435,P10644,O14578,Q86XL3,Q7LGA3,Q9UHX1,Q9UBM7 7 +Hepatic encephalopathy 0.7413146737401157 1.2670392340321397 0.2051412614915091 1.0 0.6934320472971581 4 P09622,Q9UJS0 2 +Motor polyneuropathy 0.5185221587055818 1.2666569293316383 0.2052779868944005 1.0 0.6934320472971581 12 Q15041,O43819,P07196 3 +Chorioretinal degeneration 0.6484163418935265 1.2657349983579538 0.2056079737803728 1.0 0.6934320472971581 5 P40939 1 +Ureteral duplication 0.5510749634855397 1.265093103395362 0.2058379548450939 1.0 0.6934320472971581 9 O75844,P02545,Q96J42 3 +Abnormal conus terminalis morphology 0.5740003966072577 1.2647668410250303 0.205954921232613 1.0 0.6934320472971581 8 Q5H8A4,O95202 2 +Absence of pubertal development 0.6478451930500114 1.2631177657497656 0.2065468602464879 1.0 0.6947865124704506 5 O75844 1 +Focal myoclonic seizure 0.6183208587782103 1.2605122759121747 0.2074846222745883 1.0 0.6958958431475413 6 O75503 1 +Macrogyria 0.6471895214938908 1.260112997433443 0.2076286021873752 1.0 0.6958958431475413 5 Q15392 1 +Abnormality of primary teeth 0.5061085074670979 1.2583364215908854 0.2082701145122918 1.0 0.6971263555203101 13 O75844,P02545 2 +Hypocalcemia 0.4779622751394103 1.257773755280914 0.2084735897071414 1.0 0.6972977116647194 16 P40939,P51798,P21964 3 +Limitation of movement at ankles 0.7388019477242644 1.256604015997368 0.2088970598038702 1.0 0.6982041144831544 4 O75844 1 +Abnormal size of the clitoris 0.4824860950494193 1.255043966447882 0.2094627998100569 1.0 0.6984824452982157 15 P16435,P53701,P56589,P40855,Q9UBM7,O75381,Q9Y619,P22570 8 +Abnormality of the clitoris 0.4670079620655137 1.2546922624278751 0.2095904957064311 1.0 0.6984824452982157 18 P16435,P53701,O75381,P56589,P40855,Q9UBM7,Q9Y619,P22570 8 +Deformed tarsal bones 0.8754271512892146 1.2533842249279106 0.2100659096721062 1.0 0.6995576730098724 2 O43175 1 +Glycosuria 0.5379279775669952 1.250589410584115 0.2110843160349498 1.0 0.7019664269729923 10 P35670 1 +Increased susceptibility to fractures 0.3917679895044428 1.250138046720833 0.2112491234699243 1.0 0.7019664269729923 51 O15269,P10644,Q96L58,P39210,P51798,P35670,Q04656,Q01968,P16435,P04062,Q53GS7,Q14108,Q14739,P04637,Q96AY3,P52788,Q04721,P07237,Q13126 19 +Persistence of primary teeth 0.6159755525015346 1.2491155465966846 0.2116228151661023 1.0 0.70204623586231 6 O75844 1 +Episodic respiratory distress 0.873873873873865 1.247066740228778 0.2123730270186943 1.0 0.703658531634299 2 P03886 1 +Fetal akinesia sequence 0.6151206283019053 1.2449601124582323 0.2131464126150226 1.0 0.7040472932564238 6 Q96S52,P04062,Q99567 3 +Stuttering 0.7359411641369649 1.2447234738896886 0.2132334142623677 1.0 0.7040472932564238 4 P03886 1 +Epispadias 0.8635798632691096 1.2442355204473368 0.2134128943087705 1.0 0.7040472932564238 3 P53701,Q9Y619 2 +Aplastic clavicle 0.8635798632691067 1.244235520447326 0.2134128943087745 1.0 0.7040472932564238 3 Q04656,Q9Y619 2 +Osteopetrosis 0.863579863269101 1.2442355204473037 0.2134128943087827 1.0 0.7040472932564238 3 Q15392,P51798 2 +Dermal translucency 0.5470286740870006 1.2424559173686085 0.2140683954603321 1.0 0.7051936566999 9 O75844,P02545 2 +Abnormal gastrointestinal motility 0.4313023864501971 1.2411488524091407 0.2145507654909861 1.0 0.7062745903545835 29 P04637,P06280,P00403,Q5HYI8,P03886,Q9UBM7,O76024 7 +Abnormal circulating glutamine family amino acid concentration 0.591909674985831 1.240261530221774 0.2148786764575665 1.0 0.7067889227096041 7 O96000,Q9P0J1,Q9UJS0 3 +Abnormality of the spinal cord 0.3581733051318713 1.2398909890270575 0.2150157172602049 1.0 0.7067889227096041 78 O00400,Q9HC21,Q9BXW9,P07196,P51530,Q9UHX1,Q10713,O00754,P16278,O43175,Q9Y4P3,Q96L58,O96028,P05067,Q12768,O95202,P20700,O75298,O95140,P38398,Q5H8A4,P21964 22 +Atelectasis 0.5029576074002015 1.238541406526614 0.2155153787557617 1.0 0.7075581825346884 13 Q13510 1 +Scleroderma 0.6422424167517014 1.2374347545011146 0.2159257228138937 1.0 0.7075581825346884 5 P02545 1 +Hyporeflexia of lower limbs 0.5909817612651302 1.2355409183170525 0.2166292576682613 1.0 0.7075581825346884 7 P02545,P40939,Q9NR77 3 +Abnormal urine hormone level 0.8707673190431804 1.2344393813962335 0.2170392219438293 1.0 0.7075581825346884 2 P04637 1 +Increased urinary cortisol level 0.8707673190431804 1.2344393813962335 0.2170392219438293 1.0 0.7075581825346884 2 P04637 1 +Aplasia hypoplasia of the nasal bone 0.8707673190431784 1.234439381396225 0.2170392219438324 1.0 0.7075581825346884 2 Q6NUK1 1 +Congenital craniofacial dysostosis 0.8707673190431784 1.234439381396225 0.2170392219438324 1.0 0.7075581825346884 2 Q6NUK1 1 +Bacterial endocarditis 0.8707673190431733 1.2344393813962051 0.2170392219438399 1.0 0.7075581825346884 2 P04062 1 +Aspiration pneumonia 0.4341355381719598 1.2325769198221552 0.2177336522892532 1.0 0.7075581825346884 23 P04062,P16278,Q13510,Q6NUK1 4 +Hepatitis 0.4691041391859248 1.232017945525717 0.2179423806429712 1.0 0.7075581825346884 17 P35670,Q04656,Q9Y619 3 +Type 1 muscle fiber atrophy 0.5677508491601143 1.2314583134185977 0.2181514986794899 1.0 0.7075581825346884 8 P50402,Q8WXH0,P02545,Q9BTV4 4 +Abnormality of the parathyroid gland 0.4401765634745058 1.2299393287694371 0.218719825305574 1.0 0.7075581825346884 22 P00403,P03886,P40939,P35670,P21964 5 +Axonal degeneration 0.5897475013934245 1.2292606280803764 0.218974103983478 1.0 0.7075581825346884 7 Q8TB36,Q9BQT8 2 +Delayed closure of the anterior fontanelle 0.5014078813056819 1.228797653038965 0.2191476817088868 1.0 0.7075581825346884 13 P40855,Q9Y487,O75381,Q04656 4 +Corpus callosum atrophy 0.4785166232390949 1.2284768950578808 0.219267997605985 1.0 0.7075581825346884 15 O60313,Q9H9P8,P20700,P51572,O75503,P51970 6 +Lower limb hyperreflexia 0.4631840889081189 1.227602456656616 0.2195962391637638 1.0 0.7075581825346884 18 Q15041,P13073,O00400 3 +Abnormal pulmonary valve morphology 0.4782749930368731 1.2268583994013706 0.2198758166218601 1.0 0.7075581825346884 15 P51798,P21964 2 +Right ventricular hypertrophy 0.6399253731343231 1.226809302014905 0.219894273808296 1.0 0.7075581825346884 5 P11047,Q9H267,Q969Y2,Q15233 4 +Abnormal tricuspid valve morphology 0.5009767173890205 1.2260858569528654 0.2201663674928022 1.0 0.7075581825346884 13 P51812,P53701,Q12768,P21964 4 +Mortality aging 0.379834902073038 1.226021458611574 0.220190599945079 1.0 0.7075581825346884 100 Q9NVI7,Q9HC21,Q9BT22,O43819,P40855,P16278,P07602,O43175,Q6NUK1,Q9Y4P3,O14656,P05067,Q12768,Q04656,O75844,P16435,P02545,Q96IX5,P04062,O96000,O75431,Q14739,Q15904,Q9NZJ7,O75381 25 +Wormian bones 0.4626386709870742 1.2237348406555992 0.2210522719085388 1.0 0.7075581825346884 18 O75844,P02545,O95831,Q96AY3,Q04721,P07237,Q9Y487,Q04656 8 +Upper limb amyotrophy 0.4776412132532071 1.2226125028741877 0.2214760885242144 1.0 0.7075581825346884 15 Q8TB36,Q9BQT8,Q9NR77 3 +Abnormality of the anterior fontanelle 0.4259211728932222 1.222014117549743 0.2217022883157904 1.0 0.7075581825346884 32 P16435,P20674,Q6NUK1,Q16134,P36543,P51812,Q9Y487,P56589,Q9Y619,P40855,Q15125,O75381,Q04656 13 +Hyporeflexia of upper limbs 0.8571762275690695 1.2196108914801678 0.2226124156242608 1.0 0.7075581825346884 3 Q9NR77 1 +Rigidity 0.3829829825980106 1.218315762704648 0.2231040023104227 1.0 0.7075581825346884 53 P16278,P07602,O43681,Q15392,Q96CU9,Q9NZJ7,P04062,O75787,P12235,Q9BPX6,Q9H6K4 11 +Gowers sign 0.4884702943933005 1.217847225991159 0.2232820340507526 1.0 0.7075581825346884 14 Q13510,Q8TD16,P51530,P07196 4 +Ecchymosis 0.4995154373565729 1.2168923299655403 0.2236451842564057 1.0 0.7075581825346884 13 P04062,Q8NCH0 2 +Extra axial cerebrospinal fluid accumulation 0.866418142280209 1.2167791222035107 0.2236882655460581 1.0 0.7075581825346884 2 P20700 1 +Type i diabetes mellitus 0.5102402312743028 1.216136621376904 0.2239328820959483 1.0 0.7075581825346884 12 P03886,P00403 2 +Axial muscle weakness 0.7290092853379272 1.2159391327720144 0.2240081094920751 1.0 0.7075581825346884 4 P02545 1 +Central nervous system cyst 0.3822047170861563 1.2102395043563738 0.2261870035185214 1.0 0.7088904445113087 53 O43175,O43505,Q96J42,Q9NQT5,O96028,Q01968,Q9UHX1,Q12768,Q9Y487,P23786,Q15645,Q15125,Q99567,Q9UBM7,O60566,O95202 16 +Abnormal pulmonary interstitial morphology 0.4274893991191175 1.209799846996381 0.2263557049609188 1.0 0.7088904445113087 29 P09601,Q8IZA0,P04062,Q13510,Q14108 5 +Thin clavicles 0.8546133880399269 1.2097625593768115 0.2263700167659608 1.0 0.7088904445113087 3 O75844 1 +Abnormal tongue physiology 0.4708598635581418 1.2093299203729655 0.2265361202959654 1.0 0.7088904445113087 16 P10253,Q9BQT8,Q13510,O95831 4 +Ventricular escape rhythm 0.6076219386190895 1.2084908923368285 0.2268584969508613 1.0 0.7088904445113087 6 P50402,P02545,Q8WXH0 3 +Abnormal muscle fiber protein expression 0.6076219386190895 1.2084908923368285 0.2268584969508613 1.0 0.7088904445113087 6 P50402,P02545,Q8WXH0 3 +Finger agnosia 0.863932898415654 1.2066975842255945 0.2275486297810753 1.0 0.7088904445113087 2 P05067 1 +Thickened nuchal skin fold 0.5086893541609693 1.2066616669359935 0.2275624673817295 1.0 0.7088904445113087 12 P40855,Q15125 2 +Upper limb postural tremor 0.8537989085646038 1.2066336170325789 0.2275732743871086 1.0 0.7088904445113087 3 P20700 1 +Intestinal hypoplasia 0.7267664272659162 1.206627421665171 0.2275756613740169 1.0 0.7088904445113087 4 O75844 1 +Abnormality of pain sensation 0.429778326528082 1.2053729678035972 0.2280593522560021 1.0 0.708940374042417 25 O95831,Q9NR77,P07196,Q8NCH0,P39210,O15269 6 +Megalocornea 0.5083925389840966 1.204847810229843 0.2282620592355453 1.0 0.708940374042417 12 Q5H8A4,Q9Y4P3,O95202 3 +Femoral hernia 0.863311587449516 1.2041783915274729 0.2285206359656266 1.0 0.708940374042417 2 Q04656 1 +Broad clavicles 0.863311587449516 1.2041783915274729 0.2285206359656266 1.0 0.708940374042417 2 Q04656 1 +Elbow ankylosis 0.8633115874495159 1.204178391527471 0.2285206359656273 1.0 0.708940374042417 2 P16435 1 +Humeroradial synostosis 0.8633115874495159 1.204178391527471 0.2285206359656273 1.0 0.708940374042417 2 P16435 1 +Abnormality of the musculature of the thigh 0.5396783068775892 1.2012742207975688 0.2296448469102778 1.0 0.7114715517143937 9 P50402,P02545,O14979,P07196 4 +Prominent antihelix 0.8524019173446666 1.2012679135470707 0.2296472927350674 1.0 0.7114715517143937 3 O75962 1 +Facial capillary hemangioma 0.862379621000308 1.200400517374675 0.2299838280439383 1.0 0.7114772884873434 2 P16435 1 +Broad palm 0.5836975496862987 1.1984584685558826 0.2307385821047656 1.0 0.7124423246511946 7 P10644,P51812,O95831,Q14739 4 +Infantile muscular hypotonia 0.344214289492939 1.1968502277470618 0.2313649368652377 1.0 0.7134141723272213 64 P07602,P17900,Q9NZJ7,Q15043,Q13510,Q9Y487,O43819,P03886 8 +Abnormal nephron morphology 0.3478708032063075 1.1957130721657183 0.2318085483286482 1.0 0.713655153247078 63 P02545,Q14108,Q9NZ08,Q9Y4P3,P00403,Q03252,P06280,O43819,Q8NFH4,P03886,O95470,O75431,P23786 13 +Aplasia cutis congenita of scalp 0.5829604798757381 1.194703930933641 0.2322027260856012 1.0 0.713655153247078 7 Q5H8A4,O95202 2 +Psychotic mentation 0.6329158481164444 1.194653702143742 0.2322223582306499 1.0 0.713655153247078 5 P03886 1 +Atlantoaxial abnormality 0.7237255078417049 1.1940042936868207 0.2324762884899089 1.0 0.7139563547922826 4 Q9NWM8,Q8NCH0 2 +Abnormal pleura morphology 0.4472627113505866 1.1928681306493114 0.2329210222369464 1.0 0.7146863111273362 20 Q6NUK1,P14174,Q9NZ08,P36543,Q8NCH0,Q96L58,P52732,Q9H078,O15460,Q13043,P49327,Q14739 12 +Abnormal umbilicus morphology 0.3512727670812265 1.1925998289264317 0.2330261328921408 1.0 0.7146863111273362 62 Q9BXW9,O00754,Q6NUK1,O43175,O14656,Q9Y4P3,Q04656,Q01968,O75844,P02545,Q69YQ0,Q15555,Q15056,Q14739,Q9NWM8,Q8NCH0,Q04721,P38398,Q96S52,Q9Y487,P21964 21 +Decreased adipose tissue 0.4730099276354246 1.191556599642026 0.2334351511087546 1.0 0.7153719158892339 15 O75844,P02545,O75431,Q6NUK1 4 +Severe global developmental delay 0.3452745879907749 1.1889007406660133 0.2344787286566954 1.0 0.7153719158892339 70 Q9HC21,Q13509,Q9BT22,Q9Y296,Q7LGA3,P55011,P40855,P03886,O60566,O43175,P57678,O75648,O00584,P51812,Q96S52,Q96A33,P51970,Q5H8A4,O75381 19 +Rimmed vacuoles 0.4725599628067838 1.1885366185127153 0.2346220618577807 1.0 0.7153719158892339 15 P02545,Q9BTV4,P50402,O14979,Q8WXH0 5 +Eeg with focal spikes 0.603392473078931 1.1879069190327718 0.2348700834624275 1.0 0.7153719158892339 6 Q5H8A4 1 +Extrahepatic cholestasis 0.6314083300749658 1.18773634731724 0.2349372989949116 1.0 0.7153719158892339 5 Q5HYI8,P04637 2 +Peritoneal abscess 0.6314083300749658 1.18773634731724 0.2349372989949116 1.0 0.7153719158892339 5 Q5HYI8,P04637 2 +Functional intestinal obstruction 0.6314083300749658 1.18773634731724 0.2349372989949116 1.0 0.7153719158892339 5 Q5HYI8,P04637 2 +Ovarian carcinoma 0.6314083300749658 1.18773634731724 0.2349372989949116 1.0 0.7153719158892339 5 Q5HYI8,P04637 2 +Abnormal c peptide level 0.6310869937864212 1.186261812326726 0.2355189224390037 1.0 0.7156137290239061 5 P40939 1 +Abnormal urinary electrolyte concentration 0.4519197012637916 1.1858722693112058 0.2356727458764032 1.0 0.7156137290239061 19 Q13423,P35670,Q9Y4P3 3 +Urinary glycosaminoglycan excretion 0.5806912899932712 1.1831426709625985 0.2367526089748441 1.0 0.7157979056397253 7 P16278,P34059,P54802 3 +Severe demyelination of the white matter 0.8472968555628815 1.1816717743029048 0.2373359621134509 1.0 0.7157979056397253 3 Q5H8A4 1 +Anencephaly 0.4563331536086133 1.178958889095888 0.2384145464128804 1.0 0.7157979056397253 18 O43175,Q96J42,Q15427,Q8TAA9,O43505,P21964 6 +Sound sensitivity 0.557788743079679 1.1782752691233052 0.238686883805846 1.0 0.7157979056397253 8 P17900 1 +Hyperacusis 0.557788743079679 1.1782752691233052 0.238686883805846 1.0 0.7157979056397253 8 P17900 1 +Fair hair 0.7199253963319632 1.17823353573459 0.2387035164690676 1.0 0.7157979056397253 4 P10644,O00203,Q05086 3 +Abnormality of the wrist 0.4167144187420867 1.175398840328849 0.2398351872373836 1.0 0.717884701854541 35 P16435,O75844,P16278,P02545,P34059,O95831,Q13509,Q04721,Q96DX4,Q96L58,O94905,Q13510,Q969X5,Q9H6K4,Q15125,Q04656,Q01968 17 +Oligomenorrhea 0.6287009796525846 1.1753124087667357 0.239869751875398 1.0 0.717884701854541 5 P31751,Q9UNE7 2 +Lower limb pain 0.7189928504818183 1.1743641631251465 0.2402491931143704 1.0 0.7183496429489896 4 O95140,Q8WVX9,O75477 3 +Skin dimple 0.423161475658044 1.1741402274611306 0.240338862851682 1.0 0.7183496429489896 29 P49366,Q5H8A4,Q9Y4P3,Q8TAA9,O96028,P53701,Q9UM00,Q15125,O95202 9 +Emg impaired neuromuscular transmission 0.6279582188111812 1.1719037145695983 0.2412357155570246 1.0 0.7195698597804783 5 O60313 1 +Distal upper limb amyotrophy 0.4921986174167548 1.1707970071405664 0.2416803811123036 1.0 0.7195698597804783 13 Q8TB36,Q9BQT8,Q9NR77 3 +Irritability 0.3480402790431798 1.1693286346676952 0.2422712505546009 1.0 0.7195698597804783 74 Q9HC21,P07602,O43175,P50897,O95831,Q9NZ08,Q9UJS0,P04637,P37268,Q9NZJ7,Q5KU26,Q13510,Q8NFH4,P53007,Q96RL7 15 +Tongue fasciculations 0.523822652146136 1.1692941286443193 0.2422851479020809 1.0 0.7195698597804783 10 Q9BQT8,Q13510,O95831 3 +Cytochrome c oxidase negative muscle fibers 0.5559906521469543 1.1686664366770831 0.2425380495705118 1.0 0.7195698597804783 8 P12235,Q9Y2R0,O75648 3 +Visual fixation instability 0.84353050268249 1.1672273210486264 0.2431185803254698 1.0 0.7195698597804783 3 Q13510 1 +Cranial hyperostosis 0.4915251845211983 1.166549571708259 0.2433923184354269 1.0 0.7195698597804783 13 P10644,O00754,Q15043,P51812,P48651 5 +Generalized edema 0.7170059932422476 1.1661213174629723 0.2435653988854982 1.0 0.7195698597804783 4 O43175,Q86YH6 2 +Positional foot deformity 0.3765632579284251 1.1631608764381138 0.2447642366852269 1.0 0.7207559098274303 102 Q9NVI7,Q9HC21,P07196,Q15392,Q9UHX1,Q9UM00,O00754,O14656,Q96L58,O96028,Q9UBM7,O95202,P16435,P02545,Q96J42,Q9NR77,Q69YQ0,Q8TB36,Q8TD16,Q8TAA9,Q15125,Q9NWM8,Q96AY3,Q8NCH0,P52788,Q96A33,Q969X5,Q9Y487,Q9Y619,Q5H8A4,P21964 31 +Short palpebral fissure 0.4231898972020624 1.161965132857673 0.2452496282000325 1.0 0.7212575770892413 27 O75844,P02545,Q6NUK1,P38398,Q9UHX1,Q9Y619 6 +Lower limb muscle weakness 0.4013677151827584 1.15808422405272 0.2468296672963728 1.0 0.7249730895125663 43 P02545,O00400,P07196,Q9NR77,O95140,Q13510,Q12768,O43819,P53007,O75298,P40939 11 +Papilloma 0.5106684455163921 1.153320418534073 0.2487788923097675 1.0 0.7262367720194184 11 P04637,Q99828,P21912,P16615 4 +Aganglionic megacolon 0.4418848284222712 1.153034785922049 0.2488961068307975 1.0 0.7262367720194184 20 Q9BXW9,P42892,P38398,Q10713,P21964,Q9UBM7,Q04656 7 +Asymmetry of the ears 0.8397327307916362 1.15267458604679 0.249043976426031 1.0 0.7262367720194184 3 Q9UHX1 1 +Multifocal cerebral white matter abnormalities 0.6236676460936665 1.1522123896896104 0.2492338076666571 1.0 0.7262367720194184 5 Q9Y619 1 +Depression 0.3805462692736782 1.1521629026380529 0.2492541387621569 1.0 0.7262367720194184 107 O43681,P51530,Q96N66,P55011,P03886,Q9NZ01,Q96RL7,P10644,P50897,P07602,Q9Y4P3,P06280,P00403,O14656,O15460,P35670,O76024,Q15165,P20700,P04062,P51812,Q9UBB4,Q9NZJ7,P12235,P21964 25 +Aplasia of the phalanges of the hand 0.8393412057178233 1.1511750324877068 0.2496602346129912 1.0 0.7262367720194184 3 P02545,O75962 2 +Arterial thrombosis 0.5958313034529005 1.151089533608104 0.2496954034068998 1.0 0.7262367720194184 6 Q9NZ08,P04637 2 +Aplasia hypoplasia of the cerebral white matter 0.5743903152067416 1.1510240431084875 0.249722344368662 1.0 0.7262367720194184 7 P03886,P00403 2 +Abnormal bleeding 0.3784081281517817 1.1499210905772843 0.2501763733731212 1.0 0.7262367720194184 105 P11117,P38435,Q9BXW9,Q96AA3,Q9UHX1,Q4KMQ2,Q96PU5,P10644,Q96L58,P05067,O15460,P51798,P35670,Q04656,O76024,O75844,P02545,Q9NZ08,P04062,Q14108,P23786,P21912,Q14739,Q9NWM8,Q9UJS0,P04637,Q8NCH0,Q9Y487,Q13126,P21964,O00203 31 +Abnormal atrioventricular valve morphology 0.4135250375450005 1.1477727303084349 0.2510623975709414 1.0 0.7262367720194184 35 O75844,P02545,Q9Y4P3,P04062,P53701,Q12768,O75431,P21964 8 +Cardiac conduction abnormality 0.4171167574182279 1.147726082383312 0.2510816603126029 1.0 0.7262367720194184 32 P02545,P50402,P36543,P04899,P06280,P00403,Q8WXH0,O43819,Q9H490,O75306,P03886,P23786,P21912 13 +Contractures of the large joints 0.8493320907113983 1.1476354422417796 0.2511190920994659 1.0 0.7262367720194184 2 O75431 1 +Impaired oropharyngeal swallow response 0.8493320907113975 1.1476354422417754 0.2511190920994677 1.0 0.7262367720194184 2 Q9NR77 1 +Upper limb spasticity 0.5520304269679693 1.1474947498895 0.2511772017313123 1.0 0.7262367720194184 8 Q99720,Q12768 2 +Multiple cafe au lait spots 0.4776215384475066 1.1473142183442395 0.2512517797382956 1.0 0.7262367720194184 14 P21912,Q9BXW9,Q9NP58,P38398,Q15645,Q99828,O60566 7 +Increased adipose tissue 0.7122353095942661 1.1463364173631467 0.2516559800833287 1.0 0.7265654052973278 4 P02545,O75431 2 +Babinski sign 0.3587554554152867 1.1444599818428616 0.2524329249813886 1.0 0.7269750713772191 86 O60313,O00400,O43681,P07196,O75787,O14773,P40939,P07602,Q12768,O95831,P20700,Q9NR77,Q15043,P51812,O75298,Q99720,P21912,Q9H6K4,Q9UBB4,Q9Y263,O95140,Q9NZJ7,O94905 23 +Cutaneous photosensitivity 0.4219042352449405 1.1422770888715192 0.25333886149621 1.0 0.727296957235828 25 P22830,P37268,Q9NP58,Q06136,Q14108,Q9UBM7 6 +Abnormality of the leydig cells 0.8474681578129752 1.1401183300546534 0.2542370063062678 1.0 0.7294180776167921 2 Q13423 1 +Abnormal circulating fatty acid anion concentration 0.4975017129773143 1.1381944034167026 0.2550393151132468 1.0 0.7304279810493126 12 O75880,P09622,P40939,P23786,Q16836 5 +Pulmonary embolism 0.7099782405968178 1.136979965624935 0.2555466609476013 1.0 0.7304279810493126 4 Q9NZ08,P49327,P50148 3 +High pitched voice 0.506975416181635 1.131356423535222 0.2579051047795513 1.0 0.7330524362418159 11 O75844,P02545 2 +Abnormal labia minora morphology 0.591138228860195 1.1282298283685883 0.2592228697700278 1.0 0.734518267745642 6 Q9Y619 1 +Pedal edema 0.5264093557158656 1.1267726388888306 0.2598386215951471 1.0 0.7349692260503493 9 P04062,P10644,Q14108 3 +Facial hemangioma 0.5907127550866633 1.12615719984278 0.2600989861943783 1.0 0.7349692260503493 6 P16435,Q9UBM7,Q12768 3 +Hypopigmentation of the fundus 0.8317424258061094 1.1221009619618274 0.2618195149274986 1.0 0.7357899980345022 3 P38435 1 +Abnormality of fundus pigmentation 0.8317424258061094 1.1221009619618274 0.2618195149274986 1.0 0.7357899980345022 3 P38435 1 +Cystic hygroma 0.5686404041734129 1.121698842113952 0.2619905090401948 1.0 0.7357899980345022 7 Q96S52,Q99567,Q14739,Q53EZ4 4 +Impaired pain sensation 0.4478559528798468 1.118595393030407 0.2633127897652927 1.0 0.7369861028944226 18 O95831,P07196,Q9NR77,P39210,O15269 5 +Abnormal duodenum morphology 0.4938264416439195 1.115663127942331 0.2645663592076441 1.0 0.7376067424925135 12 P38398,Q15645,Q8NCH0,Q9BXW9 4 +Rickets 0.5672747492055676 1.114732326385773 0.2649651439484262 1.0 0.7376067424925135 7 O43175 1 +Skin tags 0.4419035931930329 1.113107365225214 0.2656623208310855 1.0 0.7381479169208378 19 Q12768,Q9UHX1,O95202 3 +Aplasia hypoplasia of the proximal phalanges of the hand 0.8291770498529967 1.112298995581065 0.2660096156023637 1.0 0.7383333323694228 3 O75962 1 +Dyspnea 0.3712543416854604 1.1113860830805884 0.2664022000934818 1.0 0.738411425077514 101 P51530,Q9UHX1,O43819,P53007,P03886,P10644,P07602,P06280,Q96L58,Q13510,O75844,P02545,Q15165,O95831,Q16134,O75648,P04062,P51571,P23786,Q9NZJ7,P10253,Q969X5,P53701,P51970,P12235,Q9Y619 26 +Premature birth 0.3960664975050145 1.108566038764726 0.2676174356066501 1.0 0.7407697312068057 43 O75844,P02545,P04062,P40855,P51798,O43676 6 +Aplasia of metacarpal bones 0.839080459770112 1.1063635296083707 0.2685692043456695 1.0 0.7407697312068057 2 O75962 1 +Partial absence of thumb 0.839080459770112 1.1063635296083707 0.2685692043456695 1.0 0.7407697312068057 2 O75962 1 +Aplasia of the proximal phalanges of the hand 0.839080459770112 1.1063635296083707 0.2685692043456695 1.0 0.7407697312068057 2 O75962 1 +Easy fatigability 0.4297677008814751 1.1045689192192505 0.2693464248616408 1.0 0.7407697312068057 21 P10644,Q9NWM8,Q53H12,P53007,P12235 5 +Functional motor deficit 0.4093224543105575 1.1043343084897108 0.2694481454408635 1.0 0.7407697312068057 143 Q9HC21,O43681,P07196,P51530,Q9H2D1,O75787,Q9Y2R0,O43819,P53007,P03886,P40939,Q96RL7,P10644,P07602,P00403,Q13510,Q12768,P35670,P20700,Q9NR77,Q8TD16,P04062,O75298,Q99720,Q15041,Q9BPX6,P23786,P21912,Q9NWM8,O95140,P52788,Q9NZJ7,P53701,Q53H12,P13473,P12235 36 +Hypermetric saccades 0.8270013294901684 1.103991626552581 0.269596770007467 1.0 0.7407697312068057 3 Q9NW15 1 +Myopathy 0.3635686164804451 1.1032794243689772 0.2699058390845272 1.0 0.7407697312068057 94 O60313,P07196,P51530,P53007,P03886,P40939,O43676,Q96RL7,P10644,O00754,P50402,Q9Y4P3,P00403,Q03252,Q86Y39,O76024,P02545,P35573,O75648,Q8WXH0,P23786,P21912,Q9NWM8,P12235,O14979,Q8NCH0,Q969X5,Q53H12,P13473,Q13126,P42167 31 +Hyperpigmentation of the skin 0.3549541157373624 1.0984122062065682 0.2720245347699688 1.0 0.7418814566571185 86 Q9BXW9,Q9Y296,Q7LGA3,P55011,O60566,P16615,P10644,Q99643,P51648,Q13423,O75844,P02545,O75648,P04062,Q15645,Q99828,P21912,Q14739,P33991,P52788,Q9NP58,P38398,P53701,Q06136 24 +Mixed hypo and hyperpigmentation of the skin 0.7006408770378558 1.0983068215813525 0.2720705341809302 1.0 0.7418814566571185 4 P02545 1 +Congenital ptosis 0.836905871388627 1.0976327617129251 0.2723648810068577 1.0 0.7419148067402745 2 O75962 1 +Abnormal upper limb bone morphology 0.3670825054772115 1.0971141045545358 0.272591515262059 1.0 0.7420906946402903 98 P34059,Q9BXW9,Q9NX62,Q9Y296,Q7LGA3,Q9UHX1,P55011,P10644,P16278,Q6NUK1,Q9Y4P3,Q96L58,O96028,P48651,P51798,Q9UBM7,Q04656,O95202,O75844,P16435,P02545,O75648,P51812,O75431,Q14739,Q96AY3,Q15233,Q96S52,P38398,O00116,O15228,O75962 32 +Loss of voice 0.8244754242624058 1.0943541131315415 0.2737997007828181 1.0 0.7438114828916657 3 Q13510 1 +Hyperostosis 0.4585327441555257 1.094186092508133 0.2738733697653086 1.0 0.7438114828916657 15 P10644,O00754,Q96L58,Q15043,P51812,P48651 6 +Abnormality of corneal size 0.3980377946443355 1.0924045587839386 0.2746553201201973 1.0 0.7440567248526045 41 Q96J42,Q8NCH0,Q9Y4P3,O96028,Q5H8A4,Q15125,O95202 7 +Anomalous trichromacy 0.8238667387322269 1.0920328411690574 0.2748186663848109 1.0 0.7440567248526045 3 Q9H6K4 1 +Tritanomaly 0.8238667387322269 1.0920328411690574 0.2748186663848109 1.0 0.7440567248526045 3 Q9H6K4 1 +Intracellular accumulation of autofluorescent lipopigment storage material 0.835352593973276 1.0914019606487233 0.2750960500730155 1.0 0.7440567248526045 2 O75503 1 +Retrognathia 0.350156093785297 1.090967792728747 0.2752870547286792 1.0 0.7440567248526045 82 O75844,P02545,Q5JRA6,Q6NUK1,O43175,Q15392,P37268,Q8NCH0,P04062,Q7LGA3,P53701,Q9UHX1,Q15125,Q9Y619 14 +Bone fracture 0.5834876925950161 1.090960483599223 0.275290271028126 1.0 0.7440567248526045 6 Q13126 1 +Fulminant hepatic failure 0.8233127992517768 1.0899207436860192 0.2757480580999512 1.0 0.7440567248526045 3 P40939 1 +Nyctalopia 0.4120663805484919 1.0891057053821958 0.276107274226087 1.0 0.7440567248526045 30 P38435,Q10713,Q96S66,P40855,P40939,O75381 6 +Chorea 0.3499786086807925 1.0888079741790069 0.2762385744156863 1.0 0.7440567248526045 82 Q9P0J0,P07602,Q5XKP0,Q01105,P17900,O43681,Q9NZJ7,O43819,Q9H6K4,Q99720,Q9NZ01,P03886,Q96RL7 13 +Small earlobe 0.5191886122866773 1.0861673293849892 0.2774049686411457 1.0 0.7452723403586275 9 P21964 1 +Irregular hyperpigmentation 0.3349329377982515 1.0844274475421434 0.2781753194003662 1.0 0.7453275526824323 64 O75844,P10644,P02545,P21912,Q9BXW9,Q9Y296,O75648,Q99643,Q9NP58,Q7LGA3,Q14739,P55011,P38398,Q15645,Q99828,Q06136,O60566,P16615 18 +Abnormality of circulating glucocorticoid level 0.5087417723960299 1.0821173745047905 0.2792003764504112 1.0 0.7467619820418048 10 P16435,P04637,Q13423 3 +Loss of eyelashes 0.8212190786008083 1.0819411363408824 0.2792786845685131 1.0 0.7467619820418048 3 O75844 1 +Aplasia hypoplasia involving bones of the lower limbs 0.3587014479337058 1.0813637370841311 0.2795353456929357 1.0 0.7467866674025394 91 Q15427,Q9NX62,Q9Y296,Q7LGA3,Q9UHX1,P55011,P10644,Q96L58,O96028,Q13510,Q9UBM7,Q04656,O95202,P02545,Q5JRA6,O95831,Q69YQ0,P13073,O75648,O75431,Q96HY6,Q96AY3,Q96S52,Q96A33,O00116,Q5H8A4,Q9Y619 27 +Obstructive sleep apnea 0.4881225215028144 1.0806650126511934 0.2798461517309192 1.0 0.7468092578055378 12 Q96A33,P51530,P53007 3 +Testicular atrophy 0.5813557888943818 1.0805756134412126 0.2798859351556766 1.0 0.7468092578055378 6 P04637,O76024 2 +Reduced subcutaneous adipose tissue 0.5394605177944999 1.0802376173386292 0.2800363810909312 1.0 0.7468092578055378 8 O75844,P02545 2 +Constriction of peripheral visual field 0.4320364822691846 1.079878745305234 0.2801961792771159 1.0 0.7468092578055378 20 P40855,O75381,Q9H061 3 +Aplasia hypoplasia of the femur 0.4559631836730566 1.0768657804664148 0.2815402326194389 1.0 0.7495190262583784 15 Q96HY6,O95831,O00116,Q9UHX1,O75431 5 +Vertebral fusion 0.5077515395816509 1.0763869137538893 0.2817542524763385 1.0 0.749652947175569 10 Q9UHX1,O95202 2 +Adducted thumb 0.4103140230864958 1.0744674888196113 0.2826132085168755 1.0 0.7515016735184512 30 O43175,P42892,Q8NCH0,Q96AA3,O14656,Q86XL3,Q9Y4P3,Q04656 8 +Bilateral coxa valga 0.8306927617272344 1.072737932885787 0.2833887156998056 1.0 0.752591618008926 2 Q96A33 1 +Telangiectasia 0.407189887163969 1.0724539886312772 0.2835161697019868 1.0 0.752591618008926 33 P50148,P02545,Q8IZA0,P06280,Q99643,P10619,P03886,Q99828,P21912,Q14739 10 +Fractures of the long bones 0.8182145741607898 1.0705002351585755 0.2843942031858579 1.0 0.7535318085600059 3 Q13126 1 +Abnormal spermatogenesis 0.476282982845025 1.070236725890272 0.2845127671796628 1.0 0.7535318085600059 13 P16435,P38398,Q13423,P04062 4 +Increased blood pressure 0.3420644105062731 1.0700021809127749 0.284618327040848 1.0 0.7535318085600059 76 P16435,O75844,P02545,Q15645,P42892,P04637,Q9Y4P3,P00403,P06280,P04062,Q9NP58,Q10713,P03886,P21964 14 +Abnormal mitral valve physiology 0.3971998404756084 1.0690836226750369 0.285031990586164 1.0 0.7535318085600059 40 O75844,O00754,P02545,Q9NZ08,P06280,Q9Y4P3,P04062,P51812,P53701,O43819,P40939,O75431 12 +Abnormal endocardium morphology 0.4548037311898257 1.0690473950572388 0.2850483136630557 1.0 0.7535318085600059 15 Q9NZ08,P06280,Q9Y4P3,P04062 4 +Trismus 0.6935637554814711 1.0690398205501328 0.28505172658845 1.0 0.7535318085600059 4 P04062 1 +Nephrolithiasis 0.4304134308676979 1.0677994534291704 0.2856109846840871 1.0 0.7535318085600059 20 Q8NCH0,P35670 2 +Abnormality of the nasal bone 0.817497767156701 1.0677724720313353 0.2856231583230806 1.0 0.7535318085600059 3 Q6NUK1 1 +Pleural effusion 0.5062350549866627 1.0676100097802006 0.2856964664906023 1.0 0.7535318085600059 10 P14174,Q9NZ08,P52732,Q13043,P49327,Q14739 6 +Hypoplasia of teeth 0.4190823267399053 1.0666530858493164 0.2861285192390652 1.0 0.7535318085600059 22 O75844,P51648 2 +Aplasia hypoplasia of the phalanges of the hand 0.3684052324314326 1.066369316415665 0.2862567264296651 1.0 0.7535318085600059 53 P16435,P10644,O75844,P02545,Q6NUK1,Q5JRA6,P38435,P51812,O75962,Q9UHX1,P48651,P51798,Q14739 13 +Chronic hepatic failure 0.6925648917316076 1.064912750767779 0.2869154143789885 1.0 0.7535318085600059 4 P40939 1 +Vitritis 0.8285181733457556 1.0640431768190677 0.2873091404284096 1.0 0.7535318085600059 2 P53701 1 +Abnormal optical coherence tomography 0.8285181733457525 1.0640431768190557 0.2873091404284151 1.0 0.7535318085600059 2 Q96S66 1 +Photoreceptor layer loss on macular oct 0.8285181733457525 1.0640431768190557 0.2873091404284151 1.0 0.7535318085600059 2 Q96S66 1 +Retinal thinning 0.8285181733457477 1.0640431768190368 0.2873091404284236 1.0 0.7535318085600059 2 P51648 1 +Angiokeratoma 0.8164498389043142 1.063785912426666 0.287425694568735 1.0 0.7535318085600059 3 P16278 1 +Memory impairment 0.3997194834589594 1.0634094336531352 0.2875963165221487 1.0 0.7535318085600059 38 P07602,Q9UJS0,O43681,Q9NZ08,Q9NZJ7,P00403,P05067,O96008,P03886 9 +Ophthalmoparesis 0.3372032768104552 1.0632793295186291 0.2876552962137781 1.0 0.7535318085600059 72 Q9P0J0,O60313,P12235,Q96CU9,Q96IX5,Q7KZN9,P00403,O95299,P04062,O43819,Q10713,P53007,O15460,P03886,Q9BPX6,P21912,O76024 17 +Skeletal muscle hypertrophy 0.3891823613066984 1.0622727591203007 0.2881118773314139 1.0 0.7535743735418565 44 O00754,P16278,P02545,Q9NR77,Q9Y4P3,O75648,Q99643,O94905,Q7LGA3,P10253,Q96A33,Q10713,P53007,P21912 14 +Arteriovenous malformation 0.5768900135413677 1.0588251645281532 0.2896794109289593 1.0 0.757101611098005 6 P38398,Q9BXW9 2 +Large iliac wing 0.8266542404473384 1.0565984866542375 0.2906948714764497 1.0 0.7582871934483356 2 Q04656 1 +Atlantoaxial dislocation 0.8266542404473334 1.0565984866542175 0.2906948714764588 1.0 0.7582871934483356 2 Q8NCH0 1 +Microdontia 0.4101069175175875 1.055249427492717 0.2913112638098052 1.0 0.759199929985827 27 Q9Y4P3,Q96A33,Q7LGA3,Q9Y487,Q9Y619 5 +Knee flexion contracture 0.4095880069467321 1.051005335960969 0.2932561391372121 1.0 0.762952728935814 27 O75477,Q96AY3,P37268,Q8TD16,O94905,Q86XL3,Q7LGA3,Q969X5,P48651,P23786,P21912 11 +Abnormality of coagulation 0.3553062620393651 1.049449349590715 0.2939713553319198 1.0 0.762952728935814 57 Q5XKP0,P38435,Q9UJS0,Q96AA3,P09622,Q9Y487,P40855,P40939,P51571,O75381,Q16836,Q9Y619 12 +Brachydactyly 0.3382269277086393 1.0493083201281503 0.294036237933077 1.0 0.762952728935814 74 P16435,P10644,P02545,O95831,Q9NX62,Q06136,P51812,Q12768,Q9UHX1,P48651,O75962,Q9UBM7,Q14739,Q04656,Q92643 15 +Aplasia hypoplasia involving bones of the feet 0.337146580857488 1.0492882421628678 0.2940454758661301 1.0 0.762952728935814 73 Q15427,Q9NX62,Q9Y296,Q7LGA3,Q9UHX1,P55011,P10644,O96028,Q13510,Q9UBM7,O95202,P02545,Q5JRA6,Q69YQ0,P13073,O75648,Q96S52,Q96A33,Q5H8A4 19 +Encephalopathy 0.3610335375785032 1.0483291127574017 0.2944870009501741 1.0 0.7635651060876825 96 Q9NVI7,Q7KZN9,P09622,P53007,P03886,P40939,Q16836,O43676,P07602,Q96CU9,P00403,Q5KU26,Q86Y39,P50416,P04062,O96000,Q9Y6M9,O75208,P23786,Q9UJS0,Q9NZJ7,Q9Y619 22 +Concentric hypertrophic cardiomyopathy 0.8122240764088958 1.0477258628388222 0.2947649282062872 1.0 0.7638532010507012 3 P03886 1 +Abnormality of the elbow 0.3456328049387171 1.0471431289768314 0.2950335702287436 1.0 0.7641169219894893 60 Q9BTV4,P34059,Q15427,Q13509,Q7LGA3,P10644,P50402,O14656,Q96L58,Q13510,P48651,Q8WVM7,Q04656,P16435,P02545,Q96DX4,Q8WXH0,Q53GS7,P23786,Q9H6K4,Q96AY3,P37268,Q04721,O94905,Q969X5,Q9Y619 26 +Abnormality of the coagulation cascade 0.3947414060367376 1.0466909233842925 0.2952421513310492 1.0 0.7642248789965373 40 Q5XKP0,P38435,Q9UJS0,Q96AA3,Q9Y487,P51571,P40939,Q9Y619 8 +Abnormal renal pelvis morphology 0.3635544529451396 1.0442813954094765 0.2963552179016493 1.0 0.7662397192386518 54 P16435,Q5JRA6,P20700,Q8NCH0,Q12768,O75381,P23786,P40855,Q15125,Q9UBM7,Q04656,O76024 12 +Myotonia 0.5322294400197929 1.0415275309225691 0.2976307826348989 1.0 0.7690549255115877 8 P50402,P02545,Q8WXH0 3 +Thick hair 0.5321182309706143 1.0409321917880452 0.2979070198726756 1.0 0.7690549255115877 8 Q9Y487 1 +Abnormal carotid artery morphology 0.4416834091000288 1.0404823640733936 0.2981158534140791 1.0 0.7690549255115877 17 O75844,P02545,Q9Y4P3,P38398,Q04656 5 +Decreased cervical spine flexion due to contractures of posterior cervical muscles 0.5522253282269931 1.0379534809972824 0.2992917130166443 1.0 0.7696887924953029 7 P50402,P02545,Q8WXH0 3 +Abnormality of humoral immunity 0.3542142072325779 1.0374094650204924 0.2995450690748704 1.0 0.7696887924953029 57 P02545,P09601,Q9UJS0,P04637,Q15904,P04062,O75787,Q14108 8 +Limb girdle muscular dystrophy 0.5104351135948477 1.036909980729926 0.2997778120305385 1.0 0.7696887924953029 9 P50402,P02545,O14979 3 +Apnea 0.3409567014887401 1.030321750594886 0.3028589920175335 1.0 0.7721555258620746 78 Q9P0J0,O60313,P51530,Q7KZN9,O43819,Q10713,P53007,P03886,P07602,Q96CU9,Q86Y39,P51798,O76024,O95299,P04062,P51812,Q15645,P23786,Q9Y263,Q9NZJ7,Q96A33,O75880 22 +Ventricular arrhythmia 0.394463551536143 1.0297717122761183 0.3031171827177312 1.0 0.7722980203128241 39 P02545,P50402,P42892,O75306,P00403,Q99643,P10253,Q8WXH0,P13473,P12235,P03886,P23786,P21912 13 +Fever 0.3460998232896268 1.028766259438112 0.3035895253468188 1.0 0.7722980203128241 83 P10644,P07602,Q9NR77,Q9NZ08,Q15645,P04637,P51572,Q9NZJ7,P06280,P00403,P10253,Q13510,Q8NFH4,O15460,P03886,P23786,Q14739 17 +Abnormality of the calf 0.3470827130603184 1.02689997583251 0.3044675656995452 1.0 0.7736720218303095 59 P34059,Q15427,Q13509,Q9NX62,Q7LGA3,O00754,P16278,Q9Y4P3,Q96L58,P51798,Q04656,Q01968,P16435,O95831,Q9NR77,Q96DX4,Q15056,O75431,Q96HY6,P04637,Q04721,Q13126,Q9Y619 23 +Hoarse cry 0.8188878533705995 1.025662141928554 0.305050865052382 1.0 0.7747242989877189 2 Q13510 1 +Abnormal skin morphology of the palm 0.3498231932814085 1.0234985713821532 0.3060721750259596 1.0 0.7755637202462952 87 Q9UHX1,P56589,P40855,Q99567,P16615,P53634,Q6NUK1,Q99643,O96028,Q8WVM7,O95202,P02545,Q69YQ0,P51812,Q53GS7,O75431,Q99828,P21912,Q14739,Q9Y263,Q8NCH0,Q96S52,Q06136,Q9Y487,O75381,P42167 26 +Vertical supranuclear gaze palsy 0.478637214463416 1.0224057493947236 0.3065889004802793 1.0 0.7755754069888534 12 O15118,Q96RL7 2 +Macroglossia 0.4002410915862019 1.0221508461514794 0.3067095109655822 1.0 0.7755754069888534 34 O00754,P16278,Q9Y4P3,O75648,Q99643,O94905,Q7LGA3,P10253,Q96A33,Q96S52,Q10713,Q15056,P21912 13 +Aplasia hypoplasia of the uvula 0.595251740426609 1.0218953108830735 0.3068304520471596 1.0 0.7755754069888534 5 P38398 1 +Micromelia 0.4075272036248026 1.0217264650486957 0.3069103816256393 1.0 0.7755754069888534 23 P10644,O43175,Q15392,Q9UHX1,Q9UBM7,Q14739 6 +Abnormal heart sound 0.5950000456049299 1.02074290406211 0.3073762616554716 1.0 0.7763242703366819 5 P10253 1 +Abnormality of upper limb epiphysis morphology 0.4475288076247286 1.0199556475634066 0.3077494959810032 1.0 0.7768384465804926 15 P16435,P10644,Q5JRA6,O96028,O95202 5 +Centrocecal scotoma 0.8042262274704528 1.0174037709753587 0.3089613888453011 1.0 0.7787957659365352 3 O60313,P03886 2 +Abnormal larynx physiology 0.4577121237305266 1.0173904862283418 0.308967706049426 1.0 0.7787957659365352 14 Q13510 1 +Pelvic kidney 0.5068782934404763 1.0168911370966396 0.3092052200202273 1.0 0.7787957659365352 9 Q9UHX1 1 +Abnormality of chromosome segregation 0.5939665278235015 1.0160114034340355 0.3096239562764098 1.0 0.7789934592250992 5 Q15645,Q14739 2 +Absent toe 0.4057216492780273 1.0152900270846248 0.3099675969108402 1.0 0.7794297782837657 26 P02545,O96028,Q7LGA3,Q9UHX1,Q5H8A4,O95202 6 +Cholestasis 0.3447856508529185 1.012731305228997 0.31118852060445 1.0 0.7816413800591205 83 P00374,Q5HYI8,O75787,P56589,P40855,P40939,P10644,P39210,Q13510,Q9UBM7,P35670,Q04656,O15118,Q16134,O75648,P61916,Q14739,Q9UJS0,P04637,Q15904,P38398,P11413,O75381 23 +Opisthotonus 0.406004825226314 1.0115679194205751 0.3117446911939869 1.0 0.7819260177497055 24 P11117,P07602,Q9NZJ7,P04062,Q99720 5 +Patellar dislocation 0.4059117011439574 1.010820917615449 0.3121021496589593 1.0 0.7819260177497055 24 Q96PU5,P21964,Q9NX62,Q9Y4P3 4 +Noncompaction cardiomyopathy 0.8023260860228825 1.010215017474316 0.3123922858842869 1.0 0.7819260177497055 3 P21912 1 +Hyperactive deep tendon reflexes 0.5261808469890855 1.0091505269879133 0.3129024490182805 1.0 0.7819260177497055 8 O75787,P21912,Q9NR77 3 +Nephrotic syndrome 0.4043251113973385 1.0079196815268752 0.3134930222823078 1.0 0.7827069514889244 27 Q14108,Q9BT22,Q8NCH0,P06280,O95470 5 +Ectopic kidney 0.4368802305541307 1.0067921741450785 0.314034656167093 1.0 0.783631983972272 17 Q9BXW9,Q69YQ0,P52788,Q9Y4P3,P51530,Q9UHX1 6 +Intermittent diarrhea 0.525656642725834 1.0063450204350757 0.3142496309823004 1.0 0.7837413182287329 8 Q5HYI8,P04637 2 +Myalgia 0.384990158060453 1.0046975456541871 0.3150425103447756 1.0 0.7842506404375347 43 O60313,P02545,P21964,P20700,Q9NZ08,P06280,P12235,P40939,P23786,Q14739 10 +Generalized muscle weakness 0.3992680066518418 1.0045518029479363 0.3151127151009394 1.0 0.7842506404375347 33 Q15165,O95831,Q9NP58,P10253,P53007,P12235,P40939 7 +Metaphyseal striations 0.5657281121725235 1.0044973790424985 0.315138933916808 1.0 0.7842506404375347 6 Q13126 1 +Flaring of rib cage 0.8004972032318206 1.0033016873695288 0.3157153222448632 1.0 0.7848319547010209 3 P16278,Q96L58 2 +Prominent sternum 0.8004972032318146 1.003301687369505 0.3157153222448745 1.0 0.7848319547010209 3 P16278,O95831 2 +Skin ulcer 0.4006329111604765 1.00023073247301 0.3171988597374955 1.0 0.7872377120531121 31 Q03519,P02545,Q8IZA0,P04062,P39210,O15269,O15460,Q14739 8 +Urinary retention 0.5901894872522313 0.9987279641927334 0.3179264902414087 1.0 0.787466766339054 5 P20700,Q8TAA9 2 +Abdominal distention 0.4046272609289134 0.9986195089209712 0.3179790458530052 1.0 0.787466766339054 23 Q96HY6,P07602,O43681,Q9NZJ7,P38398,P04062 6 +Abnormal morphology of the choroidal vasculature 0.8114321217769493 0.9960988571099786 0.3192021151287627 1.0 0.7883721463275493 2 P04439 1 +Emphysema 0.4937505111827763 0.9953266995448152 0.3195773962147541 1.0 0.7883721463275493 10 Q03519,P02545,P06280 3 +Generalized osteosclerosis 0.7983321159122738 0.9951250764998836 0.3196754357877345 1.0 0.7883721463275493 3 Q15392 1 +Abnormal iris pigmentation 0.4206554884192189 0.9950692017489916 0.3197026084684693 1.0 0.7883721463275493 20 P50148,P10644,Q8IY17,Q05086,Q9Y4P3,P56589,Q15056,P40855,O75381,O00203 10 +Vocal cord paralysis 0.4153001328440187 0.994480991938206 0.3199887548793172 1.0 0.7883721463275493 21 P02545,Q9NR77,P50402,Q8TB36,O95140,Q99643,P21912 7 +Epistaxis 0.4435382033807282 0.9930067548918688 0.3207066626311703 1.0 0.7883721463275493 15 P04062,P10644,P38435 3 +Diminished movement 0.4038885352353198 0.9927304013385811 0.3208413553027887 1.0 0.7883721463275493 23 O95831,O14656,P04062,P13473,P12235 5 +Abnormal morphology of the abdominal musculature 0.4835575442821215 0.9918240701045012 0.3212833537771145 1.0 0.7883721463275493 11 Q8NCH0,Q6NUK1,Q04656 3 +Abnormal labia morphology 0.4389378300597666 0.9902793032950032 0.3220376198354686 1.0 0.789405921427522 16 P02545,Q6NUK1,Q9Y619 3 +Heterotaxy 0.5619840371952911 0.9862920253855092 0.3239898319057208 1.0 0.7913648174007455 6 Q5H8A4,O95202 2 +Hydroureter 0.4629628868260209 0.9858837862874325 0.3241901440749024 1.0 0.7913648174007455 13 P38398,Q7LGA3,O76024 3 +Atonic seizure 0.4141658250462511 0.9858324309226384 0.3242153485093246 1.0 0.7913648174007455 21 Q01105,Q13510,O43175 3 +Paranoia 0.6732273890902764 0.9852402131265412 0.3245060922293554 1.0 0.7913648174007455 4 Q96RL7 1 +Increased serum lactate 0.3637061153027049 0.9850904713527516 0.3245796334132271 1.0 0.7913648174007455 104 O14949,Q9P0J0,Q9NVI7,P20674,Q7KZN9,Q99797,P09622,O43819,P03886,P22695,Q5JRX3,P08574,Q96CU9,P00403,Q6P4A7,Q86Y39,O95831,Q70HW3,P13073,O75648,O95299,Q9Y6M9,O75208,P21912,P12235,Q5XKP0,Q9UBX3,O75880,Q9P0J1,Q53H12,P51970,O75306 32 +Proximal amyotrophy 0.4526309322804267 0.9841734414079498 0.3250302418397202 1.0 0.7916561049915313 14 P02545,Q16637,P07196,P50402,O14979,Q8WXH0 6 +Skin plaque 0.5609198874459749 0.9811198254344916 0.3265336548811701 1.0 0.7927915460080123 6 Q06136,P16615 2 +Cortical cataract 0.7941298379584452 0.9792792827083538 0.3274420040264165 1.0 0.7941509197229668 3 Q9H6K4 1 +Barrel shaped chest 0.6712188263698365 0.9769937020081474 0.3285722703244276 1.0 0.7945500272244639 4 Q32P28,Q14739 2 +Abnormal uterus morphology 0.3985320927608218 0.9758120701025568 0.3291576022494753 1.0 0.7945500272244639 30 P21912,P10644,O43175,Q9BXW9,Q69YQ0,P04637,Q99643,P38398,P51812,Q9UBM7,O60566 11 +Craniofacial asymmetry 0.7930625283719395 0.9752600175466436 0.3294312978692231 1.0 0.7945500272244639 3 O95202 1 +Widened cerebral subarachnoid space 0.7928307393918861 0.9743874396881984 0.3298642035517343 1.0 0.7945500272244639 3 P03886 1 +Axonal regeneration 0.6704814201605194 0.973967733327111 0.330072560558784 1.0 0.7945500272244639 4 Q8TB36 1 +Flat occiput 0.4365480442017853 0.9738266847828776 0.3301426011449835 1.0 0.7945500272244639 16 O00754,Q05086,Q13509,P56589,P40855,O75381,Q01968 7 +Atrophic scars 0.5193597680373278 0.9726544999879552 0.3307250460815982 1.0 0.7945500272244639 8 Q9NWM8,Q8NCH0,Q96L58 3 +Psoriasiform dermatitis 0.7922985548305328 0.9723844081552748 0.330859345748749 1.0 0.7945500272244639 3 Q15800 1 +Abnormal lumbar spine morphology 0.5192238391968438 0.9719274823433138 0.331086626512193 1.0 0.7945500272244639 8 P04062,P51812,O94905 3 +Postnatal growth retardation 0.335828719764473 0.9714680109111968 0.3313152753025352 1.0 0.7945500272244639 61 P10644,O76024,P02545,P17900,P33991,O96028,Q12768,Q9Y487,Q9UM00,Q15125,O75431,O60566,O95202 13 +Limb girdle muscle atrophy 0.4606531209547417 0.9712495751972732 0.3314240122294662 1.0 0.7945500272244639 13 P02545,Q9BTV4,P50402,O14979,Q8WXH0 5 +Juvenile aseptic necrosis 0.5838747833961573 0.969864745934034 0.3321139146562539 1.0 0.7948881670839466 5 Q9Y619 1 +Spinal muscular atrophy 0.4603884859071431 0.969572883393822 0.3322594347671268 1.0 0.7948881670839466 13 Q99720,Q13510,Q04656 3 +Cardiorespiratory arrest 0.7909752715850903 0.9674062608285084 0.3333409814637615 1.0 0.7969728145327692 3 P13473 1 +Long hallux 0.6688143994711179 0.9671302872074152 0.3334789064522354 1.0 0.7969728145327692 4 P10644,P52788 2 +Duplication of hand bones 0.3385328248476845 0.9654591483851328 0.3343148879670177 1.0 0.7976462525397594 60 P21964,Q96J42,Q9BXW9,Q9Y263,O96028,Q12768,Q9UHX1,Q10713,Q5H8A4,Q15125,Q9UBM7,Q14739,O95202 13 +Cupped ear 0.4693247295841241 0.965174372280756 0.3344574808640179 1.0 0.7976462525397594 12 Q15392,P42892 2 +Talipes equinovarus 0.3387338333114997 0.9643268558151896 0.3348820806473969 1.0 0.7982431271652423 81 Q9HC21,Q8NBU5,Q15427,Q15392,Q9UM00,O00754,O14656,Q96L58,O96028,O95202,P16435,Q9NR77,Q8TB36,P36543,Q8TD16,Q8TAA9,Q53GS7,Q15125,Q9NWM8,Q96AY3,Q8NCH0,P52788,Q96A33,Q969X5,Q9Y487,Q9Y619,Q5H8A4,Q6NUQ1,Q53EZ4,P21964 30 +Infantile spasms 0.3975937968404012 0.9621125659409484 0.3359930626157819 1.0 0.8004746273244876 29 P03886,Q13510 2 +Impacted tooth 0.7893121848753479 0.9611547433095716 0.3364743678337971 1.0 0.8012044359391353 3 O75844 1 +Abnormal epidermal morphology 0.4207742725551314 0.9589148431275404 0.3376016465721021 1.0 0.802928832380187 19 O75844,P02545,Q06136,P16615 4 +Genu valgum 0.3891650521532842 0.9568418241514668 0.3386470984059857 1.0 0.802928832380187 37 O00754,P16278,P34059,Q9NR77,Q13509,Q9NX62,Q9Y4P3,Q96L58,Q96DX4,Q7LGA3,O75431,Q15056,Q9Y619,P51798,Q04656,Q01968 16 +Hyperkinetic movements 0.4678887516140269 0.9563494465997634 0.3388957162228732 1.0 0.802928832380187 12 P07602,Q9NZJ7 2 +Thickened calvaria 0.5162897871173543 0.9562379137560492 0.3389520491353792 1.0 0.802928832380187 8 P51812,O00754,P48651,P16278 4 +Cervical myelopathy 0.8002485243864472 0.9520308185662804 0.3410813523944309 1.0 0.8047579796411986 2 P16278 1 +Abnormal insulin level 0.3981813998709989 0.950981587963807 0.3416137225510904 1.0 0.805483643440496 25 O75844,P40939,P02545,Q16836 4 +Spinal cord lesion 0.4947911342799687 0.9488805811531176 0.3426813520403653 1.0 0.806463174764516 9 O00400,Q12768 2 +Abnormal circulating pyruvate family amino acid concentration 0.3983001990839387 0.9481475716930188 0.3430543331508866 1.0 0.8068031800194708 23 Q9P0J0,Q5XKP0,P22695,Q9UJS0,Q99797,O96000,O75880,Q9P0J1,O75208,P03886 10 +Neurogenic bladder 0.5145253797319748 0.9468062430399716 0.3437375199557184 1.0 0.8075803508862158 8 O76024,P56589,Q8TAA9 3 +Abnormal oral frenulum morphology 0.4565324755408417 0.9451424823248556 0.3445861392743716 1.0 0.8087441987377487 13 O75844 1 +Attenuation of retinal blood vessels 0.5332781610578123 0.9414095804399756 0.3464950058768248 1.0 0.809658304390593 7 P38435,Q96S66 2 +Cholestatic liver disease 0.5331575730267051 0.9407961038265495 0.3468093579183766 1.0 0.809658304390593 7 P40939,Q9UBM7,Q04721 3 +Abnormal lower limb bone morphology 0.4141631402230523 0.9405790224888904 0.3469206362119117 1.0 0.809658304390593 166 P34059,Q15427,Q9BXW9,Q15392,Q13509,Q9NX62,Q9Y296,Q7LGA3,O75787,Q9UHX1,P55011,Q10713,P40939,Q99567,P10644,O00754,P16278,P07602,O43175,P06280,Q96L58,O96028,O14656,Q03252,Q13510,P51798,Q9UBM7,Q04656,O95202,O75844,P16435,P02545,Q5JRA6,O95831,Q96J42,Q69YQ0,P13073,O75648,P04062,P51812,Q15125,O75431,Q14739,Q96HY6,Q9Y263,Q96AY3,P04637,Q9NZJ7,Q96S52,Q96A33,O00116,Q969X5,Q9Y487,P38398,Q9Y619,Q5H8A4,P21964 57 +Aplasia hypoplasia of the breasts 0.5327074054956171 0.9385060790000976 0.347984394398154 1.0 0.8102421746775528 7 P02545 1 +Abdominal pain 0.3397174006083915 0.9380764715398288 0.3482051122718719 1.0 0.8102421746775528 84 P10644,O15460,Q9NZ08,P42892,Q70HW3,P04637,Q9Y4P3,P06280,Q5HYI8,P04062,P38398,Q8NFH4,Q13423,Q15645,Q14108,P23786,P21912,Q04656 18 +Soft skin 0.4837619164575266 0.937505779986476 0.3484984520017207 1.0 0.8102421746775528 10 Q13126,Q9NWM8,O00754,Q04656 4 +Renal tubular dysfunction 0.380911211727235 0.934640246603478 0.3499737304741142 1.0 0.8102421746775528 41 Q96CU9,P35670,O43819,Q86Y39,Q9Y6M9,P40855,P03886,O43676 8 +Disproportionate tall stature 0.3928398187246112 0.9343329888042724 0.350132152600999 1.0 0.8102421746775528 31 P16435,Q9NWM8,O00754,Q8NCH0,P52788,Q9Y296,O96028,Q7LGA3,P55011,Q5H8A4,O95202 11 +Truncus arteriosus 0.4640856476034727 0.9329803845649884 0.350830096211737 1.0 0.8102421746775528 12 Q9UHX1 1 +Muscle fiber inclusion bodies 0.4917233470267307 0.9316315624306468 0.3515269658919457 1.0 0.8102421746775528 9 O43676 1 +Mediastinal lymphadenopathy 0.5754532743907832 0.9314487369518648 0.3516214902115671 1.0 0.8102421746775528 5 Q9H0U3,P01889,O15460 3 +Rib fusion 0.491179101453488 0.9285722861906536 0.3531107898744352 1.0 0.8102421746775528 9 O96028,Q5H8A4,O95202 3 +Cerebral calcification 0.3920572253637154 0.9277091527049548 0.3535584594478704 1.0 0.8102421746775528 31 O60313,O43175,P00403,P05067,P03886,P23786,Q04656 7 +Abnormality of blood circulation 0.3218016155368298 0.9268334651458932 0.3540130067404461 1.0 0.8102421746775528 68 O75844,P02545,P38435,Q9UJS0,Q9NZ08,P05067,P04062,Q9UHX1,Q9Y487,P21964,Q14739,Q04656,O76024 13 +Delayed epiphyseal ossification 0.6584714875713747 0.9248159578118772 0.3550616484127797 1.0 0.8102421746775528 4 Q9UG56,Q96HY6 2 +Distal sensory impairment 0.3708048178516753 0.9240979003100354 0.3554353464145621 1.0 0.8102421746775528 46 P02545,O95831,P20700,P07196,Q9NR77,Q8TB36,P54802,P39210,O15269,Q6UWE0,Q04656 11 +Cogwheel rigidity 0.5488703804213684 0.9226394509064608 0.3561951294225625 1.0 0.8102421746775528 6 P12235 1 +Blurred vision 0.6572367583157024 0.919777956821854 0.3576888047617319 1.0 0.8124438653757222 4 P04439,P03886 2 +Abnormal pelvis bone morphology 0.7775015537600823 0.9169280435544088 0.3591803475896387 1.0 0.8135808807509329 3 P16435,Q04656 2 +Temporal pattern 0.5282445321993285 0.9158166144437966 0.3597630877947173 1.0 0.8135808807509329 7 P04062,Q12768,Q9NR77 3 +Buphthalmos 0.7770709772944084 0.9153216229825548 0.3600228108139529 1.0 0.8135808807509329 3 P50148 1 +Increased intracranial pressure 0.4192714052308967 0.9141194688365556 0.3606540735441943 1.0 0.8143170625043717 18 P10644,P07602,Q9NZ08,Q9NZJ7,P21912 5 +Recurrent abscess formation 0.7903075489282322 0.9131702890175998 0.3611529873874231 1.0 0.8147650037437713 2 O00203 1 +Cyanosis 0.4234899288665201 0.9127788884382104 0.3613588437963551 1.0 0.8147650037437713 17 O75844,P02545,P53007 3 +Abnormality of circulating adrenocorticotropin level 0.5463245599729404 0.9103079031416372 0.3626601517797596 1.0 0.8156992364847175 6 P16435,Q13423 2 +Recurrent fever 0.4413027301430147 0.9101065193075084 0.3627663367709535 1.0 0.8156992364847175 14 Q13510,P51572 2 +Central sleep apnea 0.5706473617593159 0.9095732366911132 0.3630476182476205 1.0 0.8156992364847175 5 Q96A33 1 +Bradykinesia 0.3932375954879071 0.9090049874618364 0.3633474931533449 1.0 0.8159726194944416 24 Q15043,P04062,O75787,P12235,Q96RL7 5 +Abnormal blood ion concentration 0.3266324288341609 0.9065907962171466 0.3646232306512493 1.0 0.8171684656857717 74 Q13423,P04637,Q15904,Q9Y4P3,Q15043,Q9NP58,O75962,Q9Y487,O43819,P05023,P40939,P51798,P35670,P21964 14 +Xerostomia 0.430714753171221 0.9063764901867568 0.36473661205518 1.0 0.8171684656857717 15 Q92804,Q15165,P55011,Q53GS7,Q14739 5 +Abnormal platelet morphology 0.5694210910357834 0.903997748385206 0.3659965953179913 1.0 0.8171684656857717 5 P04637 1 +Abnormality of bladder morphology 0.468386993399244 0.9014068915439308 0.3673720185709561 1.0 0.8171684656857717 11 P16435,Q04656,Q9Y4P3 3 +Retinal detachment 0.4585802311353406 0.8991657066255525 0.3685644036924502 1.0 0.8171684656857717 12 P50148,P04439,Q8NCH0,P52732,O43505 5 +High myopia 0.4858828743044379 0.8988170175974 0.3687501341370494 1.0 0.8171684656857717 9 Q9Y487,P52788,O15460 3 +Abnormality iris morphology 0.3311854265169059 0.8974486243059738 0.3694795761680798 1.0 0.8171684656857717 79 Q9BXW9,Q7LGA3,Q9UHX1,P56589,Q10713,P40855,O43505,P10644,Q9Y4P3,Q99643,O96028,Q12768,Q9UBM7,Q01968,O95202,Q96J42,Q9NR77,Q15056,Q15645,P21912,P50148,Q8IY17,Q05086,P38398,P53701,Q5H8A4,O75381,O00203 28 +Abnormal fallopian tube morphology 0.5244859962308611 0.8967291343536609 0.3698634703611909 1.0 0.8171684656857717 7 P04637,P53701 2 +Pseudobulbar signs 0.467567943376581 0.8965298404906967 0.3699698502838153 1.0 0.8171684656857717 11 P20700,O94905,P17900 3 +Metaphyseal widening 0.3971942921208246 0.8960435494126345 0.3702295045748327 1.0 0.8171684656857717 22 P16278,Q96HY6,O95831,Q96L58,P48651,Q14739,Q04656 7 +Abnormal cutaneous elastic fiber morphology 0.7710729556951738 0.892990567957981 0.3718622237407589 1.0 0.8171684656857717 3 Q9Y487 1 +Abnormal circulating apolipoprotein concentration 0.7710729556951738 0.892990567957981 0.3718622237407589 1.0 0.8171684656857717 3 Q9Y487 1 +Prominent veins on trunk 0.7710729556951738 0.892990567957981 0.3718622237407589 1.0 0.8171684656857717 3 Q9Y487 1 +Scanning speech 0.770975761342442 0.8926294430148791 0.3720556464107942 1.0 0.8171684656857717 3 Q9UBB4,O14773 2 +Abnormal blood potassium concentration 0.4667682960413798 0.8917690148417423 0.3725167529173712 1.0 0.8171684656857717 11 P05023,P04637,Q13423 3 +Abnormality of limb epiphysis morphology 0.3877001396616814 0.8908158190354551 0.3730279871668034 1.0 0.8171684656857717 31 P16435,P10644,Q5JRA6,O95831,Q96DX4,Q96L58,O96028,Q7LGA3,P51812,Q9Y2Q9,O15228,Q04656,O95202 13 +Increased circulating antibody level 0.4478779183620444 0.8903319116746036 0.3732876908304272 1.0 0.8171684656857717 13 P04062 1 +Bifid tongue 0.6496295896661348 0.888809290428607 0.3741055820403933 1.0 0.8171684656857717 4 Q9UBM7 1 +Abnormal sternum morphology 0.3671380026961132 0.8887246836389188 0.3741510619093904 1.0 0.8171684656857717 116 Q9NVI7,Q7LGA3,Q9UHX1,P55011,P53007,O60566,O00754,P16278,P50402,Q9Y4P3,Q96L58,Q99643,O96028,Q13510,Q04656,O95202,P02545,O95831,Q69YQ0,P04062,P51812,Q8WXH0,O75431,P21912,Q14739,Q9Y263,Q96AY3,Q8NCH0,P52788,Q96S52,Q96A33,Q9Y487,O75962,Q9Y619 34 +Abnormal atrioventricular conduction 0.4279910809092204 0.8879812644096998 0.3745508294634661 1.0 0.8171684656857717 15 P50402,P02545,P21912,P06280 4 +Scrotal hypoplasia 0.4199200326897682 0.8877103543845387 0.3746965747246453 1.0 0.8171684656857717 17 P16435,Q6NUK1,Q15555,P46977,Q9UBM7 5 +Short nose 0.347736408851297 0.887177502913313 0.3749833425740401 1.0 0.8171684656857717 96 Q9NVI7,P38435,Q15392,Q9NX62,Q9UHX1,Q9UM00,O60566,P10644,Q6NUK1,P42892,Q9Y4P3,Q96L58,Q5KU26,Q12768,O75844,P16435,P20700,P04062,Q9Y263,Q8NCH0,Q9Y487,O75962 22 +Aplasia hypoplasia involving the skeletal musculature 0.4836892046691681 0.886502141812956 0.3753470005208812 1.0 0.8171684656857717 9 Q9Y487,O43175 2 +Anal atresia 0.3897651650965773 0.8852849392625498 0.3760029707889256 1.0 0.8171684656857717 26 Q9BXW9,Q69YQ0,P38398,P53701,Q12768,P21964 6 +Progressive 0.3512956250138392 0.8823614575304526 0.3775813715002347 1.0 0.8171684656857717 100 O60313,O00400,P54802,Q96RL7,Q03252,P39210,Q13510,Q12768,O95470,P02545,P20700,Q15043,P04062,Q9Y6M9,O75298,Q99720,Q13126,Q5XKP0,P12235 19 +Iris coloboma 0.3850284160687987 0.8821186934235756 0.377712624281217 1.0 0.8171684656857717 33 O96028,P53701,Q12768,Q9UHX1,Q10713,Q5H8A4,O95202 7 +Pain insensitivity 0.6479633390256037 0.8820431358468226 0.3777534809577814 1.0 0.8171684656857717 4 O15269 1 +Abnormal heart valve physiology 0.3350768890841116 0.8812581039643924 0.378178136803188 1.0 0.8171684656857717 84 Q9UHX1,O43819,P40939,O60566,Q96PU5,O00754,P16278,Q6NUK1,P10644,Q9Y4P3,P06280,Q12768,O75844,P02545,Q9NZ08,P04062,P51812,Q15645,Q15125,O75431,Q15904,P53701 22 +Abnormality of the calcaneus 0.5021340587777476 0.8806650569127281 0.378499135072625 1.0 0.8171684656857717 8 P40939,O43175,Q14739 3 +Hyperaldosteronism 0.7819198508853604 0.8806351298669639 0.3785153381140356 1.0 0.8171684656857717 2 P04637 1 +Abnormal vertebral morphology 0.3626664822651164 0.8800714888721507 0.3788205832519096 1.0 0.8171684656857717 112 P34059,Q15427,P54802,Q9UHX1,Q10713,P10619,Q9UM00,P10644,O00754,P16278,Q6NUK1,Q9Y4P3,Q96L58,O96028,Q12768,P51798,Q9UBM7,Q04656,O95202,Q01968,P16435,Q5JRA6,O95831,Q96DX4,Q8TAA9,P04062,P51812,Q15056,Q53GS7,Q14108,Q15125,Q14739,Q96HY6,Q96AY3,Q8NCH0,Q04721,P15586,P07237,Q9Y2Q9,O15228,Q5H8A4,Q6NUQ1,Q9Y619 43 +Spinal rigidity 0.4366904295005999 0.8799651711537816 0.3788781776018057 1.0 0.8171684656857717 14 P50402,P02545,O94905,P53007 4 +Pes cavus 0.353016219890278 0.8794788492917 0.3791416961902432 1.0 0.8171684656857717 102 O60313,O00400,P07196,Q9Y296,Q7LGA3,Q9NW15,O15269,Q10713,P53007,P05023,Q6UWE0,P40939,Q96RL7,P39210,Q12768,Q04656,P02545,O95831,Q9NR77,Q8TB36,P04062,O75298,Q99720,Q14739,Q9H6K4,O95140,P13473 27 +Absent facial hair 0.4736187303478157 0.8788637819265457 0.3794751383249997 1.0 0.8171684656857717 10 O75844,P02545 2 +Hepatic necrosis 0.5016077537320993 0.8778604728110131 0.3800194421298739 1.0 0.8171684656857717 8 P40939,Q16836 2 +Abnormal response to endocrine stimulation test 0.7668895345826048 0.8774691959410592 0.3802318431902765 1.0 0.8171684656857717 3 Q13423 1 +Anteriorly placed anus 0.4731999246520424 0.8764450532684156 0.3807881349268525 1.0 0.8174537598828212 10 P16435,P53701,Q6NUK1 3 +Spinal deformities 0.7662783481154225 0.8752054224526769 0.3814621433403917 1.0 0.8185169420598191 3 Q8TB36 1 +Aplasia hypoplasia involving the vertebral column 0.413558071273773 0.8731833543120661 0.3825631462632708 1.0 0.8185372826586171 18 P10644,P16278,Q96HY6,O95831,P34059,Q04721,Q8TAA9,Q14739 8 +Chromosomal breakage induced by crosslinking agents 0.7653139284728873 0.8716353523996812 0.3834073381925731 1.0 0.8188562658784644 3 P13073 1 +Recurrent pancreatitis 0.7648078011618373 0.869762788947071 0.384430050781841 1.0 0.820272694561999 3 P03886 1 +Abnormal circulating proline concentration 0.6448056597209846 0.8692387334414148 0.3847165656593374 1.0 0.8205017019814188 4 O96000,Q9P0J1 2 +Exercise induced muscle stiffness 0.778813296054674 0.8686484781146863 0.385039430036223 1.0 0.820807984234574 2 P46020 1 +Stomach cancer 0.4803432577325918 0.8677315502357645 0.3855413097658622 1.0 0.8209667070861247 9 Q15645,P10644,P04637 3 +Ocular anterior segment dysgenesis 0.3421165298381866 0.8675298658090786 0.385651755174111 1.0 0.8209667070861247 92 O76024,P02545,O00400,Q9NVI7,O43175,Q96J42,Q9Y4P3,P00403,O96028,Q99797,Q7LGA3,Q53H12,Q15800,P03886,O95202 15 +Impairment of activities of daily living 0.3299809798774639 0.8667325530413804 0.3860885647760514 1.0 0.8214693274726919 60 Q9UBB4,P07602,P20700,O43681,Q9NZJ7,Q12768,O15269,O75298,Q99720,O75962,P21964 11 +Abnormality of bone mineral density 0.3848067661091605 0.8640817160649691 0.3875430023079416 1.0 0.8214693274726919 138 Q9HC21,Q9BXW9,Q15392,P54802,P10644,O00754,P16278,P07602,O43175,Q9Y4P3,P06280,O96028,Q13510,P48651,P51798,P35670,Q04656,O95202,O75844,P02545,Q5JRA6,O95831,P57678,Q15043,P04062,Q14108,Q15125,O75431,Q14739,Q9NWM8,Q96HY6,P12235,P52788,Q9NZJ7,P38398,Q9Y487,Q13126,Q5H8A4 38 +Gingival bleeding 0.4618980294330473 0.8627900386749291 0.3882529170119015 1.0 0.8214693274726919 11 P04062,Q14108 2 +Narrow pelvis bone 0.7772600186393197 0.8626685849888335 0.3883197095066499 1.0 0.8214693274726919 2 P16435 1 +Flattened femoral head 0.777260018639319 0.8626685849888323 0.3883197095066506 1.0 0.8214693274726919 2 P16278 1 +Fragile nails 0.4707320444472387 0.8621974876192892 0.3885788519995306 1.0 0.8214693274726919 10 P02545 1 +Abnormal dentin morphology 0.5601105581188077 0.8617589663761158 0.3888201695418307 1.0 0.8216001644356451 5 Q5JRA6,Q96L58 2 +Alkalosis 0.642700938772746 0.8607176418172863 0.3893935742265573 1.0 0.8220531011449543 4 O00170,Q9Y619 2 +Impaired distal tactile sensation 0.6423755730103642 0.8594013739244964 0.3901191119788005 1.0 0.8232052597930543 4 O15269 1 +Abnormality of globe size 0.3292074267634015 0.8577885740053586 0.3910092201374828 1.0 0.824703463385322 60 P50148,Q6NUK1,O43175,O43505,Q9BXW9,Q96J42,Q9NP58,P38398,P53701,Q9UHX1,Q15645,Q15125,O75431,O60566,P21964,Q01968 16 +Finger swelling 0.7753960857409148 0.855504794623006 0.3922717512344238 1.0 0.8262246315098558 2 Q01968 1 +Intestinal polyp 0.4015831236549357 0.8526159418275457 0.3938723190703017 1.0 0.8275949131953183 20 P21912,P42892,P04637,Q15645,O60566,Q04656 6 +Generalized onset seizure 0.3537075102188298 0.8526034909835728 0.39387922600125 1.0 0.8275949131953183 105 Q9NVI7,Q96N66,Q9NW15,P55011,P05023,P03886,Q9NZ01,P16278,P07602,O43175,Q9Y320,Q13510,Q01105,P04062,P51812,O75503,Q14108,P21912,Q9UBB4,Q9Y263,P52788,Q9NZJ7,Q9Y619 23 +Aplasia hypoplasia of the sternum 0.6404604934131525 0.8516594332467793 0.3944031423066025 1.0 0.8275949131953183 4 Q9Y619 1 +Absent brainstem auditory responses 0.7598335082352001 0.8513968127342885 0.3945489616740292 1.0 0.8275949131953183 3 O60313 1 +Absent hair 0.4598239649064084 0.8504591845841788 0.3950698433204405 1.0 0.8281774189654916 11 O75844,P02545 2 +Aplasia hypoplasia of the 5th finger 0.4415059086594793 0.8500196737669782 0.3953141483170952 1.0 0.8281774189654916 13 Q9UHX1 1 +Short long bone 0.3810626311268158 0.847971980861826 0.3964535751849083 1.0 0.8293106079359046 33 P10644,P16278,Q96HY6,Q9BXW9,Q96L58,P38398,Q96S52,O00116,Q9UHX1,O15228,Q04656 11 +Acetabular dysplasia 0.4957638034243488 0.8467515683745426 0.3971336085248047 1.0 0.8295725317322165 8 P16278,O00203,Q96L58 3 +Abnormality of the brainstem white matter 0.7585469344946849 0.8466580186877924 0.3971857649222472 1.0 0.8295725317322165 3 Q10713 1 +Progressive microcephaly 0.3741597345284129 0.8457973537598845 0.3976658019550589 1.0 0.8295725317322165 39 P50897,Q9HC21,Q9Y263,Q9NQT5,Q9BT22,Q15043,Q5KU26,Q9Y487 8 +Abnormality of the gingiva 0.3663549766150542 0.8452261947600469 0.3979845596358327 1.0 0.8295877772249854 44 P50148,P10644,O00754,P16278,P53634,Q5JRA6,P20700,O00203,Q15392,Q9Y4P3,Q96S52,P04062,Q15056,Q9UM00,Q14108,Q9UBM7,Q14739,Q01968 18 +Abnormality of temperature regulation 0.3519953093405153 0.8435810818457511 0.398903539456837 1.0 0.8306408854810626 104 Q9HC21,P03886,P10644,P07602,P06280,P00403,Q13510,O15460,P51798,Q04656,P20700,Q9NR77,Q9NZ08,Q8NFH4,Q15645,P23786,Q14739,Q13144,Q5XKP0,P04637,P51572,Q9NZJ7,P10253 23 +Aplasia of the uterus 0.4949399337228016 0.8423710874339477 0.3995802714432135 1.0 0.8316718467902157 8 O95202 1 +Focal white matter lesions 0.4946623709501708 0.8408956093748609 0.4004064183396605 1.0 0.8330127167547957 8 O00584,P12235 2 +Reduced tendon reflexes 0.4063488817411074 0.8388338838522489 0.4015625335906749 1.0 0.8346594831192468 167 O60313,Q9HC21,O43681,P07196,Q9BT22,P54802,O75787,O15269,O43819,Q10713,P53007,P40855,P03886,P40939,P05023,Q6UWE0,Q96RL7,P07602,P50402,P39210,Q13510,P50416,Q04656,P02545,O95831,Q9NR77,P57678,Q8TB36,Q9BQT8,Q8TD16,P04062,Q99720,Q15041,Q9H6K4,Q9UBB4,O95140,Q9NZJ7,P10253,P12235,Q5H8A4,O75381 41 +Abnormal head movements 0.4573962029913435 0.8360345676386525 0.4031354566137963 1.0 0.8357231891331603 11 Q99720,Q96RL7 2 +Abnormal motor evoked potentials 0.7701149425287279 0.835281053625931 0.4035594823986512 1.0 0.8357231891331603 2 P07196 1 +Abnormal pyramidal sign 0.3654213422723169 0.8347021022776899 0.4038854577021395 1.0 0.8357231891331603 119 Q9P0J0,O60313,O00400,Q9H9P8,O43681,P07196,O75787,O14773,P40939,P07602,P17900,Q12768,P51648,O95831,P20700,Q9NR77,Q9NZ08,Q15043,P51812,O75298,Q99720,P21912,Q9H6K4,Q9UBB4,Q9Y263,O95140,P51572,Q9NZJ7,O94905,Q9Y619 30 +Abnormality of pancreas physiology 0.3652454154142767 0.8346483663161841 0.4039157214248687 1.0 0.8357231891331603 44 P02545,P09601,Q9UJS0,Q9NZ08,P04637,P00403,Q5HYI8,Q9UHX1,P03886,Q14739 10 +Abnormality of facial musculature 0.3249050837626226 0.833061144981698 0.4048102455889419 1.0 0.8357231891331603 78 O60313,P07196,P51530,O75787,Q9UHX1,O43819,P53007,P40855,Q13510,P48651,P51798,Q9BQT8,Q15043,P04062,P51812,Q9Y263,P10253,P12235,O75381 19 +Hand muscle weakness 0.4386264942591332 0.8318216849487784 0.4055096019161568 1.0 0.8357231891331603 13 P07196,Q8TD16,Q9NR77 3 +Paraplegia paraparesis 0.32472036953812 0.8307845697366582 0.4060953410299681 1.0 0.8361108662662878 78 Q9P0J0,O60313,O00400,Q7KZN9,O75787,O00754,Q96CU9,Q13510,Q12768,O95831,O95299,P04062,O75298,Q15041,P21912,Q9H6K4,Q5XKP0,O94905,Q9Y619 19 +Diplopia 0.4074887585654891 0.8297171456772114 0.406698725140483 1.0 0.836550963756811 18 O15460,P04062,Q9NW15,P53007 4 +Short femur 0.552743021193592 0.8284684558884541 0.4074052520588969 1.0 0.836550963756811 5 Q9UHX1 1 +Shawl scrotum 0.5526286652162331 0.8279527760101861 0.4076972446455278 1.0 0.8367752950389384 5 Q9UM00,Q9Y619 2 +Patchy changes of bone mineral density 0.7528782457032499 0.825837323349748 0.4088963787182433 1.0 0.8370254771762006 3 Q13126 1 +Asymmetric septal hypertrophy 0.7676296986641672 0.8258028822198243 0.4089159188563356 1.0 0.8370254771762006 2 P54802 1 +Megaloblastic anemia 0.4916992051501108 0.8251541207143898 0.409284096825333 1.0 0.8373416178154448 8 O43175 1 +Complete atrioventricular canal defect 0.7523305104870782 0.8238307278088102 0.4100357453640462 1.0 0.8373416178154448 3 Q9UHX1 1 +Abnormal cns myelination 0.3768356523158673 0.8207855388494372 0.4117684371484627 1.0 0.8402351487089175 133 Q9P0J0,O00400,Q9H9P8,O43681,Q7KZN9,Q7LGA3,O75787,O43819,P40855,P03886,O43676,P07602,O43175,Q96CU9,P51648,Q86Y39,O95831,P20700,Q8TB36,O95299,O00584,O96000,Q9Y6M9,Q99720,P21912,Q13144,P51572,Q9NZJ7,P10253,Q5H8A4 30 +Telangiectasia of the skin 0.40584066316025 0.8179208577321305 0.4134023795475059 1.0 0.8416332288042102 18 P02545,Q8IZA0,Q14739,P06280 4 +Abnormality of the antitragus 0.7506150693149862 0.8175524040275045 0.4136128146109914 1.0 0.8416332288042102 3 Q92643 1 +Irregular menstruation 0.526995092290091 0.8170668224213617 0.4138902417960497 1.0 0.8416332288042102 6 P02545 1 +Calcific stippling 0.7504661280298227 0.8170077350096824 0.4139240077019177 1.0 0.8416332288042102 3 Q15125,O15228 2 +Increased circulating lactate dehydrogenase concentration 0.4355280233366443 0.8122555372812812 0.4166450177980318 1.0 0.8426507944789801 13 Q9UJS0,P04637,P10253,P23786,Q96RL7 5 +Abnormality of the upper arm 0.3864399069887357 0.8120656143550105 0.4167539825643342 1.0 0.8426507944789801 22 P16435,P02545,P50402,O14979,O00116,Q8WXH0,P48651,Q04656 8 +Immunodeficiency 0.3222179908631838 0.8119823486928669 0.4168017599975229 1.0 0.8426507944789801 61 P21912,O00754,P09601,Q9BT22,P35573,Q03252,O96028,Q96A33,O60566,P21964,O95202 11 +Eyelid myoclonus 0.4619598716498633 0.8116397390751394 0.4169983817251357 1.0 0.8426507944789801 10 Q13510 1 +Bilateral talipes equinovarus 0.5258154264865647 0.8114033363644108 0.4171340837916992 1.0 0.8426507944789801 6 Q15392,Q15125 2 +Agenesis of corpus callosum 0.3262575728249152 0.8111441599981016 0.4172828885173221 1.0 0.8426507944789801 81 Q9HC21,Q9BXW9,Q15392,Q86XL3,Q7LGA3,P55011,Q9UHX1,Q10713,P03886,O60566,O43175,P00403,O96028,P48651,O95202,O14578,P23786,P53701,Q5H8A4 19 +Lipodystrophy 0.3758949808243796 0.8110014231693787 0.41736485346484 1.0 0.8426507944789801 34 O75844,P02545,Q6NUK1,P50402,Q9Y487,O75431,P42167 7 +Functional abnormality of male internal genitalia 0.3802535625826402 0.8102627581933337 0.4177891747502049 1.0 0.8426507944789801 27 P16435,Q9Y4P3,P38398,P04062,Q13423,O76024 6 +Abnormal foot bone ossification 0.5486650541791964 0.8101003654561656 0.4178824942670998 1.0 0.8426507944789801 5 Q15125 1 +Macule 0.3219706526100058 0.8090786196534439 0.4184699254323631 1.0 0.8429526314130734 61 O75844,P10644,P02545,P21912,P50148,Q9BXW9,Q9Y296,O75648,Q99643,Q9NP58,Q7LGA3,P38398,P55011,Q15645,Q99828,Q06136,O60566,P16615 18 +Abnormality of skin pigmentation 0.3749267249552738 0.8084546466748415 0.4188289044615261 1.0 0.8429526314130734 132 Q9BXW9,Q9Y296,Q7LGA3,P55011,P03886,O60566,P16615,P10644,P07602,Q8IZA0,P00403,Q99643,P51648,Q13423,P51798,Q04656,O75844,P02545,O75648,P04062,Q15645,Q15125,O75431,Q99828,P21912,Q14739,P33991,P50148,P52788,Q9NZJ7,Q9NP58,P38398,P53701,Q06136,P21964,O00203 36 +Abnormal cellular phenotype 0.4147462566702283 0.8054964873383291 0.4205332325779305 1.0 0.8449414971366143 182 Q9P0J0,P20674,Q9BXW9,P51530,Q7KZN9,O75787,O14773,P09622,Q9Y2R0,P03886,P40939,O43676,O60566,Q16836,Q92643,P07602,P09601,Q96CU9,P00403,Q13510,Q86Y39,P51798,O75844,P02545,Q70HW3,P13073,O95299,P04062,O96000,O75503,Q9Y6M9,Q15645,Q14108,P23786,P21912,Q14739,P33991,Q9UJS0,Q9UBX3,P04637,Q15904,Q9NZJ7,P38398,O75880,Q9P0J1,P51970,P12235,P21964,O00203 49 +Ovarian cyst 0.3997059340262693 0.8048489831716563 0.4209068313064323 1.0 0.8453212195404183 19 P16435,P10644,P02545,Q9Y4P3,Q03252,Q99643,P21912 7 +Alopecia totalis 0.5243464482873715 0.804355996012734 0.4211914069747111 1.0 0.8455218994025437 6 O75844 1 +Palmar pits 0.7462082320495942 0.8014672105908573 0.4228612191446008 1.0 0.8469224187957523 3 P16615 1 +Abnormal patella morphology 0.3777402749600991 0.8011279273333735 0.4230575900165152 1.0 0.8469224187957523 30 Q96PU5,Q9NX62,Q9Y4P3,Q15125,P21964 5 +Acanthocytosis 0.5461525502036182 0.7988061017407578 0.4244028519281217 1.0 0.848157906058815 5 Q96RL7 1 +Holoprosencephaly 0.4510691925118435 0.7984964608665129 0.4245824461291527 1.0 0.848157906058815 11 Q15645,Q9UBM7,Q96J42 3 +Joint stiffness 0.3325842033517692 0.797831959288598 0.4249680123048625 1.0 0.848157906058815 57 Q9BTV4,Q15427,P54802,Q9UBC1,O00754,P16278,P50402,Q9Y4P3,P51648,O15460,Q01968,P16435,O75844,P02545,O76024,Q8TAA9,Q8WXH0,Q15056,O75431,O95140,Q96AY3,P15586 22 +Depressed nasal ridge 0.4029160394420034 0.7969976813149554 0.4254523779504242 1.0 0.848157906058815 18 P10644,P16278,O43175,Q96J42,Q15645,O60566 6 +Mask like facies 0.4419047677619013 0.7969705053337809 0.4254681612179729 1.0 0.848157906058815 12 P04062,Q04656 2 +Joint contracture of the hand 0.3536820340810745 0.7950969316387698 0.4265571193829827 1.0 0.8492195868063815 48 P16435,O75844,P02545,O43175,Q9NR77,Q15392,P42892,Q8IZA0,Q9Y619 9 +Abnormal metacarpal morphology 0.3756402149232 0.7945691102272915 0.426864192801774 1.0 0.8493530561923648 32 P16435,P10644,P16278,P34059,Q9BXW9,Q9NX62,Q96DX4,Q96L58,Q15233,Q96S52,P51812,O75962,Q14739 13 +Verrucae 0.7442510876320517 0.7943440994448384 0.4269951376621148 1.0 0.8493530561923648 3 Q99828,P16615 2 +Abnormality of the anus 0.3624932876816873 0.7926554956984998 0.4279785661465531 1.0 0.849603055234401 43 P16435,Q6NUK1,Q9BXW9,Q69YQ0,P38398,P53701,Q12768,P48651,P21964,P16615 10 +Oculomotor apraxia 0.3786272482076525 0.7926124044022561 0.4280036793914314 1.0 0.849603055234401 25 Q9UNE7,Q9NQT5,Q13509,P05067,P04062,O14773,Q10713,O96008 8 +Athetosis 0.4231805393645786 0.7918331201415805 0.4284579877036236 1.0 0.8497856799038478 14 O14949,O43175 2 +Neoplasm of the stomach 0.3885980332432341 0.7906684228927358 0.4291375073828449 1.0 0.8502724400548223 21 P21912,P10644,P04637,Q15645,O60566 5 +Scaphocephaly 0.6251999031953747 0.7903335242775715 0.4293330132902162 1.0 0.8502724400548223 4 P40855,Q969X5 2 +Optic nerve dysplasia 0.7579993786890329 0.7893234925779665 0.4299229593390672 1.0 0.8503746137423709 2 O43505 1 +Craniofacial osteosclerosis 0.7427141692255619 0.788759529030923 0.4302525676477089 1.0 0.8506591136696283 3 P51798 1 +Distal arthrogryposis 0.5436951942037256 0.7877773783502757 0.4308269353535849 1.0 0.8510597657394589 5 Q8NCH0 1 +Periodontitis 0.4572881264917536 0.7847819330090656 0.4325814347492076 1.0 0.8530535700760645 10 Q01968,Q5JRA6,P53634,O00203 4 +Abnormality of complement system 0.7412202059665617 0.7833388525214567 0.433428153511199 1.0 0.8543553658750668 3 P02545 1 +Diaphyseal thickening 0.7408031041681737 0.7818268369070493 0.4343163469357307 1.0 0.8543706260470867 3 Q14739 1 +Abnormal platelet granules 0.7558247903075399 0.7811433883202691 0.4347181654710326 1.0 0.8543706260470867 2 O00203 1 +Long fingers 0.3196310712448968 0.7809535666894636 0.4348298049934362 1.0 0.8543706260470867 77 P16435,Q9Y263,P42892,Q8NCH0,Q03252,O96028,P51812,Q9UHX1,P23786,Q5H8A4,Q15125,O75962,Q06136,P21964,O95202 15 +Hypoplastic female external genitalia 0.4305364689129987 0.7807775277751249 0.4349333532985828 1.0 0.8543706260470867 13 Q6NUK1,Q9Y619 2 +Intellectual disability progressive 0.4480148824740631 0.7804079670203664 0.4351507798888629 1.0 0.8543706260470867 11 P53701,Q9H9P8 2 +Increased muscle lipid content 0.4646816025422398 0.7801514411046936 0.4353017406787187 1.0 0.8543706260470867 9 O00483,P23786,Q9Y4W6,O75648 4 +Deposits immunoreactive to beta amyloid protein 0.7396397742961607 0.7776129472916126 0.4367972259101376 1.0 0.8562048362339555 3 P05067 1 +Kyphoscoliosis 0.3359825797196349 0.7771741702991567 0.4370560191822223 1.0 0.856345533519639 55 Q13509,P51530,P53007,O14656,Q96L58,Q5KU26,O75844,P02545,Q9NR77,Q8TB36,P36543,Q96DX4,P51812,Q9NWM8,Q96AY3,Q8NCH0,P52788,Q04721,Q15233,Q9Y487 20 +Macular atrophy 0.500461778328317 0.7753743675375959 0.4381184768781363 1.0 0.8570680711581554 7 P04062 1 +Abnormality of dental structure 0.3160105029749202 0.7752812644956109 0.4381734777421362 1.0 0.8570680711581554 74 O75844,P16278,P02545,Q5JRA6,Q9Y4P3,O75431,Q6P4Q7,P53701,P51648,Q9Y487,P48651,P51798,P21964,O00203 14 +Motor neuron atrophy 0.3814911092793124 0.773446390164102 0.4392582444169624 1.0 0.8580902308810882 22 Q99720,Q13510 2 +Hemiparesis 0.4072244661764878 0.7721060572674171 0.4400516149471472 1.0 0.859273494602553 16 Q9NZ08,P03886,P00403 3 +Azoospermia 0.4375697309705594 0.7704928468693998 0.4410075965697149 1.0 0.860318894207178 12 P38398,P04062,Q13423 3 +Incomplete penetrance 0.3753831280583384 0.7702516410847826 0.4411506362957968 1.0 0.860318894207178 27 O60313,Q9UBB4,O95140,O14656,Q6UWE0,P03886,P21912 7 +Caesarian section 0.6197473972226423 0.7685975595335361 0.4421322547299326 1.0 0.8610213239925353 4 O60313,P33991 2 +Posteriorly rotated ears 0.3496189300657303 0.768377450422718 0.4422629731448881 1.0 0.8610213239925353 108 Q4J6C6,Q15427,Q15392,Q7LGA3,Q9UHX1,P56589,Q10713,P40855,Q9UM00,Q99567,O43505,O60566,Q6NUK1,P42892,Q9Y4P3,Q96L58,O96028,Q9UBM7,O95202,Q01968,P16435,Q96J42,Q69YQ0,P04062,Q15555,Q15056,Q53GS7,Q15645,P23786,Q8IY17,Q9Y263,P37268,Q8NCH0,Q96S52,Q9Y2Q9,Q5H8A4,O75381,Q9Y619,O00203 39 +Abnormal oral mucosa morphology 0.3325432726518502 0.7678557899100513 0.4425728652190666 1.0 0.861040369465751 56 Q15392,Q9UM00,P10644,O00754,P16278,P53634,Q9Y4P3,Q9UBM7,Q01968,Q5JRA6,P20700,Q9NZ08,P04062,Q15056,Q14108,O75431,Q14739,P50148,Q96S52,O00203 20 +Metaphyseal cupping 0.7369055535503325 0.7677279319257724 0.4426488381136444 1.0 0.861040369465751 3 Q14739 1 +Abnormality of hair texture 0.3399558649927113 0.766972099909011 0.4430981039454387 1.0 0.8611826052487963 53 O75844,Q9NVI7,Q6NUK1,O43175,P54802,Q96A33,Q9Y487,Q15125,P51798 9 +Spastic paraplegia 0.3486682786279805 0.7652954166142832 0.4440956526985893 1.0 0.8617477487647599 49 Q9P0J0,O60313,O00400,O95831,Q96CU9,Q7KZN9,O95299,O94905,P04062,Q12768,O75298,Q15041,Q9Y619 13 +Abnormal shape of the occiput 0.372819011864142 0.7647498117259411 0.4444205385545383 1.0 0.8617477487647599 31 O00754,O43175,Q05086,Q13509,Q04721,O14656,Q96L58,Q12768,P56589,P40855,O75381,Q04656,Q01968 13 +Dyskinesia 0.3055099223442946 0.7646992552841317 0.4444506497550631 1.0 0.8617477487647599 65 Q9P0J0,Q9UBB4,Q01105,Q9UBX3,Q15043,P04062,O43819,P03886,Q9NZ01,Q96RL7 10 +Aplasia hypoplasia of the hallux 0.3803230776599196 0.7643364360531983 0.4446667774905137 1.0 0.8617477487647599 22 Q9Y296,O96028,Q7LGA3,Q9UHX1,P55011,Q5H8A4,O95202 7 +Abnormality of the ankles 0.3540433877764738 0.7609639140059151 0.4466786213624791 1.0 0.864599030793183 46 O75844,O00754,P02545,P07602,O95140,Q96AY3,Q9Y4P3,Q15043,O94905,Q15233,O75787,Q9NW15,Q9NZJ7,O75298 14 +Abnormal labia majora morphology 0.4529812032966623 0.760072366688059 0.4472113292524322 1.0 0.864599030793183 10 Q6NUK1,Q9Y619 2 +Hypoplastic labia majora 0.4529812032966623 0.760072366688059 0.4472113292524322 1.0 0.864599030793183 10 Q6NUK1,Q9Y619 2 +Increased serum pyruvate 0.3691082017532315 0.759929398943721 0.4472967874224614 1.0 0.864599030793183 35 O95831,P22695,Q96CU9,Q70HW3,O96000,Q86Y39,Q9Y6M9,P03886,O43676 9 +Lipid accumulation in hepatocytes 0.3105010189445444 0.7597454647642254 0.4474067467072309 1.0 0.864599030793183 70 P02545,Q8N511,Q5XKP0,Q9UJS0,Q15904,Q7KZN9,Q03252,O75880,O75787,P39210,P35670,P40939,O75431,P23786,Q16836 15 +Hand tremor 0.4181240112830686 0.7589418595336477 0.4478873371221867 1.0 0.864599030793183 14 Q16637,P07196,O95140,O14656,O94905,Q9NP58 6 +Eeg with generalized slow activity 0.4970725091916965 0.7583733494281825 0.4482275076519224 1.0 0.864599030793183 7 O75503 1 +Rheumatoid arthritis 0.7496116806461615 0.7578942953003391 0.4485142656907159 1.0 0.864599030793183 2 Q9UBC1 1 +Abnormality of the hallux 0.3341137097679354 0.7569498057427996 0.449079934735701 1.0 0.864599030793183 55 P10644,O95140,P52788,Q9Y296,Q9Y4P3,Q96L58,O96028,Q7LGA3,O75648,Q9UHX1,P55011,P04062,Q15233,Q5H8A4,Q15125,O95202 16 +Absent eyebrow 0.5368037462532756 0.7569481040773615 0.4490809542539677 1.0 0.864599030793183 5 O75844 1 +Mild short stature 0.6167859435802387 0.7568348352230554 0.449148819939096 1.0 0.864599030793183 4 Q14739 1 +Frontotemporal dementia 0.4524016527879625 0.7567515008334812 0.4491987539325142 1.0 0.864599030793183 10 P05067 1 +Optic atrophy 0.4113216787083231 0.7563335969212885 0.4494492095830482 1.0 0.8647176179331 183 Q9P0J0,O60313,Q9NVI7,Q9H9P8,Q9HC21,O43681,Q9H061,Q7KZN9,O43819,P40855,P03886,Q96PU5,P16278,P50897,P07602,P10644,Q96CU9,P06280,P00403,O96028,Q5KU26,Q12768,Q86Y39,O15460,P51798,Q9UBM7,O76024,O95202,Q96J42,P57678,Q15043,O95299,P51812,Q6P4Q7,Q15125,Q9BPX6,Q9H6K4,Q13144,Q5XKP0,Q9Y263,P51572,Q9NZJ7,Q5H8A4,O75381,P21964 45 +Aplasia hypoplasia affecting the anterior segment of the eye 0.3726861688439792 0.7544305497920767 0.4505907332248415 1.0 0.8653135966910652 29 Q96J42,Q9BXW9,Q9Y4P3,O96028,P38398,Q7LGA3,Q15645,P21912,O95202 9 +Single transverse palmar crease 0.3599474056042706 0.7541780248549005 0.450742331056825 1.0 0.8653135966910652 42 Q8IY17,Q9Y263,O96028,Q96S52,P51812,Q9UHX1,P56589,Q53GS7,P40855,O75381,Q8WVM7,O95202 12 +Periauricular skin pits 0.4347965044821983 0.7535810255946787 0.4511008413408537 1.0 0.8653135966910652 12 O96028,O95202 2 +Vomiting 0.3327332999012014 0.7530490089255009 0.451420464190718 1.0 0.8653135966910652 92 P11117,P22695,P03886,P40939,Q16836,O43676,P07602,O43175,Q96CU9,P06280,P00403,P39210,Q86Y39,Q13423,Q9Y6M9,P51571,P23786,Q9UJS0,Q9NZJ7,Q9Y619 20 +Abnormal nasal mucosa morphology 0.7328164423896055 0.7529958085781779 0.451452432727649 1.0 0.8653135966910652 3 Q03519 1 +Hypodontia 0.3531975519624024 0.7527291498111058 0.4516126895238455 1.0 0.8653135966910652 46 O75844,P10644,P02545,Q9Y4P3,O96028,O75962,Q5H8A4,O75431,O95202 9 +Neoplasm of the male external genitalia 0.4594083654262074 0.7508010688403375 0.4527723860816426 1.0 0.8663777167033311 9 Q13423,P04637 2 +Scapular winging 0.3735095776448903 0.7503324561139294 0.4530544997573218 1.0 0.8663777167033311 24 O60313,P02545,P07196,P50402,Q9Y487 5 +Weakness of facial musculature 0.3198039377200937 0.7489635957334864 0.4538791475402006 1.0 0.86668582843477 60 O60313,P12235,P07196,Q9BQT8,Q15043,Q13510,Q9UHX1,O43819,P53007,P40855,P48651,P51798,O75381 13 +Abnormal pulmonary thoracic imaging finding 0.3780851144511064 0.7468886939349595 0.4551307511735922 1.0 0.8672674613499287 22 P04062,Q13510,P21964 3 +Unilateral ptosis 0.730593969313094 0.745015266352323 0.456262490967295 1.0 0.8677212519400409 3 Q9UHX1 1 +Abnormal levels of alpha fetoprotein 0.5334111610140955 0.7418293483490799 0.4581907365581263 1.0 0.8696347231754173 5 Q9UJS0 1 +Eruption failure 0.5112264481115397 0.7416948512975395 0.4582722400136017 1.0 0.8696347231754173 6 O75844,P02545 2 +Pancreatic islet cell hyperplasia 0.7291489826604005 0.7398368205434617 0.4593990141043647 1.0 0.8706904327747873 3 Q14739 1 +Abnormality of the lymph nodes 0.3646912650719774 0.7388050391793007 0.4600253914485535 1.0 0.8710972354678681 37 P10644,Q9NZ08,P04637,Q5HYI8,Q13510,O15460,Q15645,P51798,P33991 9 +Abnormal cranial nerve morphology 0.3045123124936734 0.7387439863930856 0.4600624705532299 1.0 0.8710972354678681 66 P07196,Q13509,P51530,Q9UHX1,O43819,P56589,P53007,P40855,P10644,Q99643,Q13510,P48651,P51798,Q15043,P51812,P21912,P50148,P12235,O75381 19 +Palmar telangiectasia 0.7440198819509022 0.7371320788799856 0.4610420328887041 1.0 0.871957237993133 2 Q14739 1 +Childhood onset 0.3621432730972559 0.7367274039010443 0.4612881383494158 1.0 0.871957237993133 39 Q8WWV3,P22830,Q5JRX3,Q9NR77,P50402,Q8TB36,O00165,Q15904,Q14566,O75431 10 +Lymphocytosis 0.7433985709847692 0.734834988312961 0.4624399956649871 1.0 0.8721222158772571 2 Q03252 1 +Fibroadenoma of the breast 0.7433985709847689 0.7348349883129596 0.462439995664988 1.0 0.8721222158772571 2 P10644 1 +Lactic acidosis 0.327134699442245 0.7338268013724475 0.4630543037593069 1.0 0.8725084745088973 88 Q9HC21,Q99797,P09622,O43819,Q10713,P03886,P40939,Q16836,O43676,Q96CU9,P00403,P39210,Q86Y39,Q70HW3,O95299,O96000,Q9Y6M9,O75208,Q5XKP0,Q9UJS0,Q9P0J1,Q53H12,P12235 23 +Cold induced muscle cramps 0.7270633782226035 0.732377100995851 0.4639384314941845 1.0 0.8726841933904891 3 Q9NR77 1 +Typical absence seizure 0.42254356348415 0.7305097990115031 0.4650786254897165 1.0 0.87302121815924 13 Q13510 1 +Craniofacial dysostosis 0.5304723118868985 0.7287659850487577 0.4661448218465329 1.0 0.8740692625861075 5 Q6NUK1 1 +Abnormality of the palm 0.3509550495248707 0.727557058922207 0.4668847749152316 1.0 0.8747403372900351 113 Q9UHX1,P56589,P40855,Q99567,P16615,P10644,P53634,Q6NUK1,Q99643,O96028,P48651,Q8WVM7,Q04656,O95202,P16435,P02545,O95831,Q69YQ0,Q96DX4,P51812,Q15555,Q53GS7,O75431,Q99828,P21912,Q14739,Q8IY17,Q9Y263,Q8NCH0,P52788,Q96S52,Q9Y487,Q9Y2Q9,O75381,O75962,Q06136,Q9Y619,P42167 38 +Abnormal circulating carbohydrate concentration 0.3582050171320357 0.7246368245678867 0.4686748614575484 1.0 0.8763775935663415 41 O95831,P22695,Q9UJS0,Q96CU9,Q70HW3,O96000,Q86Y39,Q9Y6M9,P03886,O43676 10 +Hemianopia 0.4725272347244942 0.7238667251536737 0.4691475600380297 1.0 0.8763775935663415 8 P03886 1 +Conjunctival hamartoma 0.7246737103791052 0.7238513148060318 0.4691570218311767 1.0 0.8763775935663415 3 Q99643,P21912 2 +Glucose intolerance 0.344881284233583 0.722606267024537 0.4699218168597492 1.0 0.8763775935663415 107 O60313,Q5HYI8,P03886,O43676,P10644,Q96CU9,Q9Y4P3,P00403,Q03252,Q86Y39,O76024,O75844,P02545,Q5JRA6,O96000,Q9Y6M9,O75431,P04637,P12235,Q06136 20 +Abnormality of the skull base 0.3202398944467792 0.7211438600355019 0.47082100813909 1.0 0.8763775935663415 59 Q9Y289,Q96AA3,Q9UHX1,Q10713,Q99567,O60566,O43505,O00754,O43175,Q96L58,Q12768,P48651,Q9UBM7,Q96J42,P36543,Q15645,Q15125,P23786,Q14739,Q04721,Q9Y487 21 +Disproportionate short trunk short stature 0.5068294309605466 0.7208230323501532 0.4710184026369743 1.0 0.8763775935663415 6 P16278,P34059,Q9UHX1 3 +Prominent nasolabial fold 0.4893742001223385 0.7199001789138799 0.471586457861425 1.0 0.8763775935663415 7 Q8NCH0,Q9Y487 2 +Abnormality of the nasolabial region 0.4893742001223385 0.7199001789138799 0.471586457861425 1.0 0.8763775935663415 7 Q8NCH0,Q9Y487 2 +Bowing of the legs 0.3377234606402118 0.7193226727732602 0.4719421293123265 1.0 0.8765103961444657 52 P34059,Q13509,Q9NX62,Q7LGA3,O00754,P16278,Q9Y4P3,Q96L58,P51798,Q04656,Q01968,P16435,Q9NR77,Q96DX4,Q15056,O75431,Q96HY6,Q04721,Q13126,Q9Y619 20 +Otitis media 0.3080406219872428 0.7166791138057539 0.4735721161959834 1.0 0.8765103961444657 63 Q03519,O00203,Q03518,Q9Y4P3,O96028,Q96A33,Q8N5M9,Q5H8A4,P21964,P51798,Q9UBM7,O95202,Q14739,Q12959 14 +Cataplexy 0.6062837984665647 0.7153842204595137 0.4743716601852792 1.0 0.8769715115002346 4 O15118 1 +Aplasia hypoplasia involving the femoral head and neck 0.4446334447350945 0.7123458008232791 0.4762506688950654 1.0 0.8769715115002346 10 O75431,Q96HY6,O95831,Q96L58 4 +Hyperlipoproteinemia 0.4364502708376378 0.7121657028248941 0.4763621723589779 1.0 0.8769715115002346 11 P02545,Q8N511,Q9UJS0 3 +Increased ldl cholesterol concentration 0.4364502708376378 0.7121657028248941 0.4763621723589779 1.0 0.8769715115002346 11 P02545,Q8N511,Q9UJS0 3 +Chronic otitis media 0.3670446806147309 0.7113034248033371 0.47689622976595 1.0 0.8769715115002346 30 Q03519,Q9Y4P3,O96028,Q5H8A4,P21964,O95202 6 +Hip dysplasia 0.3368561737368609 0.710285153719231 0.4775273243947426 1.0 0.8769715115002346 52 P02545,Q9NVI7,Q8TD16,Q9Y296,Q96L58,O96028,Q96A33,Q7LGA3,Q9UHX1,P55011,Q15125,Q04656,O95202 13 +Progressive spastic paraplegia 0.3680351352248249 0.7099562859055523 0.4777312446097963 1.0 0.8769715115002346 27 Q9P0J0,O00400,Q96CU9,Q7KZN9,Q12768,O75298 6 +Prolonged neonatal jaundice 0.3779482891074416 0.7095384003883652 0.4779904304958071 1.0 0.8769715115002346 21 O15118,P61916,P39210,Q04656 4 +Peripheral hypermyelination 0.7203597599928809 0.7085198690214907 0.4786224779652792 1.0 0.8769715115002346 3 Q9NR77 1 +Neuroinflammation 0.6042566492417623 0.7074336741596619 0.4792970166205061 1.0 0.8769715115002346 4 Q9NZ08,P49327 2 +Abnormality of the lymphatic system 0.3841772949599945 0.7070994360823778 0.4795046863960084 1.0 0.8769715115002346 153 Q15392,Q9BT22,P54802,Q5HYI8,Q10713,P10619,Q96RL7,P10644,P16278,P07602,O96028,Q13510,O15460,P51798,P35670,O15118,O95202,P02545,Q96J42,Q9NZ08,P04062,P61916,Q15645,Q14108,Q14739,P33991,Q96HY6,Q9UJS0,P04637,Q15904,Q9NZJ7,P10253,Q96A33,P21964,O00203 35 +Pseudoarthrosis 0.7199509513438559 0.7070710708679993 0.4795223126133987 1.0 0.8769715115002346 3 O75844 1 +Abnormal arachnoid mater morphology 0.469322050101791 0.7070508987911784 0.4795348478090728 1.0 0.8769715115002346 8 Q9UHX1 1 +Multifactorial inheritance 0.4187369872382085 0.7066432422957709 0.4797882092653547 1.0 0.8769715115002346 13 P42892,P04637,P10321 3 +Vacuolated lymphocytes 0.7196722635866217 0.7060838255739709 0.4801360096098754 1.0 0.8769715115002346 3 P16278 1 +Unsteady gait 0.3446681621937441 0.7054097145468481 0.4805553002000355 1.0 0.8769715115002346 48 Q13144,Q9UBB4,Q5JRX3,O95831,P07196,Q9NR77,P52788,O75787,O75503,Q10713,Q9H6K4,Q04656 12 +Hypoplasia of the musculature 0.5035032600138291 0.7050829593136809 0.4807586105878734 1.0 0.8769715115002346 6 Q9Y487 1 +Spondyloepimetaphyseal dysplasia 0.4859982018057202 0.7030972072038263 0.481995172504543 1.0 0.8772131856140053 7 Q96HY6,O95831,Q96L58 3 +Flared iliac wing 0.5030643959311052 0.7030094537165659 0.4820498579862153 1.0 0.8772131856140053 6 P16278,O95831 2 +Cavernous hemangioma 0.5246052618547342 0.7027854418724886 0.4821894711051433 1.0 0.8772131856140053 5 Q99643,P21912,P50570 3 +Coloboma 0.3496877756661464 0.7019183110836787 0.4827301088057343 1.0 0.8776619449914763 45 Q9NP58,O96028,P53701,Q12768,Q9UHX1,Q10713,Q5H8A4,O95202 8 +Abnormal basal ganglia mri signal intensity 0.3668813823377302 0.7005003590847924 0.4836148809911029 1.0 0.878062069808985 27 Q9P0J0,P16278,Q96CU9,Q7KZN9,O95299,P03886 6 +Limb myoclonus 0.5238663324060815 0.6995231178409529 0.4842251708084246 1.0 0.878648553904224 5 Q13510 1 +Retinal arteriolar tortuosity 0.4257042494717136 0.6983093907936639 0.4849837276682818 1.0 0.878648553904224 12 P21964 1 +Chronic sinusitis 0.6018179244593826 0.6978918077606289 0.4852448580491928 1.0 0.878648553904224 4 Q03519 1 +Abnormal sputum 0.5232177469831317 0.6966615332614152 0.4860146373341865 1.0 0.878648553904224 5 Q9NZ08,P49327,Q86Y56 3 +Abnormal circulating serine concentration 0.7168658946053729 0.6961610798949152 0.4863279584859858 1.0 0.878648553904224 3 O43175 1 +Demyelinating peripheral neuropathy 0.396031426557715 0.6955224612050965 0.4867279399877642 1.0 0.878648553904224 16 P03886,Q9NR77 2 +Pulmonary fibrosis 0.3845871177221719 0.6946489801621373 0.4872753088863177 1.0 0.8787844188225479 19 P04062,Q8IZA0,P09601 3 +Tonic seizure 0.3660519564972164 0.6919787179126167 0.4889506941295947 1.0 0.8792532248629373 26 P07602,Q9NZJ7 2 +Abnormality of the septum pellucidum 0.3532312510984804 0.6914808299370402 0.4892634236625386 1.0 0.8792532248629373 42 Q9UBB6,O43175,Q15392,Q69YQ0,Q96N66,O96028,P53701,P55011,P51571,P48651,Q9NZ01,O95202 12 +Decreased circulating cortisol level 0.4835241959959034 0.6908127786237459 0.4896832040434835 1.0 0.8793174083588671 7 Q13423 1 +Exercise induced muscle cramps 0.5002575467063992 0.6897667044475035 0.4903409101705431 1.0 0.8801532840732722 6 P13473 1 +Aphasia 0.3557018864627658 0.6894499908426914 0.4905401335528374 1.0 0.8801658587533082 40 Q9H9P8,Q9Y296,P00403,P05067,Q7LGA3,P53701,P55011,O96008,P03886,P21964 10 +Talipes valgus 0.5995345150715736 0.6889808976879187 0.4908352886735927 1.0 0.8801789816399829 4 O00754 1 +Abnormal cerebral artery morphology 0.398183261416539 0.6874966815738506 0.4917697911957401 1.0 0.8803025308386607 15 P10253,P05067,P38435 3 +Prolonged partial thromboplastin time 0.5207470985981242 0.6857773192242824 0.4928535408089241 1.0 0.8815532669390873 5 P28288,P38435 2 +Sensory axonal neuropathy 0.397719959453395 0.6844015655903639 0.4937216276793628 1.0 0.8819424482617984 15 Q8IV08,O95831 2 +Heterotropia 0.3406218175370002 0.6843490341617328 0.4937547907027828 1.0 0.8819424482617984 49 Q9NVI7,O43175,P20700,Q5KU26,P04062,Q9UHX1,O43819,P40939 8 +Generalized amyotrophy 0.3646747525516129 0.6824263930025791 0.4949693715386529 1.0 0.8824750924737464 27 P02545,P51530,Q03252,O43819,P13473,Q99567 6 +Joint subluxation 0.4815094471515957 0.6808278916513988 0.4959803992450178 1.0 0.8830070949233811 7 P16278,Q9UHX1,Q96L58 3 +Limited elbow extension 0.4227329114409188 0.680314517081531 0.4963053344501984 1.0 0.8832421789535401 12 P16435,Q15427,Q96L58,Q9H6K4,Q8WVM7,Q04656 6 +Sepsis 0.377815451592209 0.6755094779877542 0.4993521317330061 1.0 0.8863748173478129 20 P42892,Q9BT22 2 +Adrenocortical carcinoma 0.7107719892366229 0.6747350525929571 0.4998441101883113 1.0 0.8867827123410608 3 P04637 1 +Anterior uveitis 0.7097576134244923 0.6711850637814871 0.5021026425207165 1.0 0.8880370799932398 3 Q9UNE7,P14174 2 +Pleuritis 0.7097576134244791 0.67118506378144 0.5021026425207464 1.0 0.8880370799932398 3 Q9NZ08,P49327 2 +Orchitis 0.7097576134244791 0.67118506378144 0.5021026425207464 1.0 0.8880370799932398 3 Q9NZ08,P49327 2 +Dysplasia of the femoral head 0.708145282308972 0.6655523838907789 0.5056972502559431 1.0 0.8894279157215823 3 O75431 1 +Abnormal myocardium morphology 0.3901491638520229 0.664933238875119 0.5060931947990297 1.0 0.8894279157215823 165 Q9P0J0,O60313,Q9NVI7,Q9BT22,Q9H061,Q7KZN9,P54802,Q99797,P09622,O43819,P40855,P03886,P40939,O43676,Q16836,Q96RL7,P16278,P50402,Q96CU9,Q9Y4P3,P06280,P00403,Q86Y39,P50416,Q13423,O76024,P02545,Q9NZ08,P35573,Q96IX5,O95299,P04062,O96000,Q9Y6M9,Q14108,P23786,P21912,Q5XKP0,P10253,P53701,Q53H12,P13473,P12235,O75381,P42167 45 +Abnormal renal cortex morphology 0.3279539711241186 0.6646165702967307 0.5062957680473139 1.0 0.8894279157215823 54 P02545,Q14108,Q9NZ08,P06280,P00403,Q99643,Q03252,Q8NFH4,P03886,O95470,O75431,P21912 12 +Adrenal overactivity 0.5931855892259643 0.6643277985218151 0.5064805328488973 1.0 0.8894279157215823 4 P10644,P04637 2 +Muscle fibrillation 0.4032029541066407 0.6623737237389596 0.5077317393249676 1.0 0.8896684429516708 14 Q9BQT8,Q13510,O95831 3 +Lacticaciduria 0.4941449694602282 0.661046138209764 0.50858272540352 1.0 0.8905535791789351 6 O96000,Q9BQT8,P03886 3 +Reticulocytosis 0.4112471873613695 0.6598532742380725 0.5093479918737303 1.0 0.8905535791789351 13 P49327,Q8NBF2,Q9NP58,P11413,P51798 5 +Breech presentation 0.4427304660936741 0.6586230700326517 0.5101378446612266 1.0 0.891427436055782 9 O60313,Q9UBM7,Q9Y619 3 +Amyotrophic lateral sclerosis 0.3905883551465621 0.6584496372325493 0.51024924872291 1.0 0.891427436055782 16 Q92804,Q99720,Q15165,Q53GS7 4 +Dysmetric saccades 0.4764212242729449 0.6556923506019671 0.5120220916173057 1.0 0.8919021773607583 7 O95140,Q9NW15,O14773 3 +Tremor by anatomical site 0.3603850330219704 0.6555106300920432 0.5121390445812599 1.0 0.8919021773607583 30 P20700,Q9NR77,P07196,O95140,O14656,Q9NP58,Q99720,Q96RL7 8 +Mildly elevated creatine kinase 0.3616182213916509 0.655151851165651 0.5123699909518695 1.0 0.8919021773607583 25 P02545,O75648,Q9BPX6,P39210,P40939,Q16836 6 +Abnormality of the musculature of the upper limbs 0.3052312930254593 0.6548953651434648 0.5125351245531333 1.0 0.8919021773607583 73 O60313,P02545,P07602,P07196,P50402,Q9NR77,Q8TB36,Q9BQT8,Q8TD16,O95140,Q9NZJ7,Q9Y487,P12235 13 +Maternal diabetes 0.7213420316868533 0.6546683088341159 0.5126813335472411 1.0 0.8919021773607583 2 Q8TAA9 1 +Absence of the sacrum 0.7213420316868533 0.6546683088341159 0.5126813335472411 1.0 0.8919021773607583 2 Q8TAA9 1 +Asymmetry of spinal facet joints 0.7213420316868533 0.6546683088341159 0.5126813335472411 1.0 0.8919021773607583 2 Q8TAA9 1 +Vertebral hypoplasia 0.4184142922542423 0.6542297797051634 0.5129637783393242 1.0 0.8919021773607583 12 P10644,P16278,Q96HY6,Q04721,Q8TAA9,Q14739 6 +Focal motor seizure 0.3748345574824992 0.6534129522358127 0.5134900909425251 1.0 0.8921806658067187 20 P21912,O75503,Q9UBB4,Q01105 4 +Paraplegia 0.3313311070905949 0.6527518519439061 0.5139162684232124 1.0 0.8921806658067187 52 Q9P0J0,O60313,O00754,O00400,O95831,Q96CU9,Q7KZN9,O95299,O94905,P04062,Q12768,O75298,Q15041,Q9Y619 14 +Neonatal death 0.4015849667929361 0.6519583021192159 0.5144280722434698 1.0 0.8922599025768364 14 Q9NVI7,Q6NUK1,Q16134,P04062,O96000,Q53GS7,Q14739 7 +Epileptic spasm 0.308553393111957 0.6515308225059347 0.5147038870789777 1.0 0.892400264647724 61 Q01105,O43175,Q9UBX3,P13073,Q13510,P03886 6 +Abnormality of the uterus 0.3193379931153205 0.6507373716883047 0.5152160344320111 1.0 0.8924014653825698 57 P21912,P10644,O43175,Q9BXW9,P04637,Q99643,O96028,P51812,P38398,P53701,Q9UBM7,O60566,P21964,O95202 14 +Abnormal ovarian physiology 0.3609354158444379 0.6504217074696074 0.5154198592370163 1.0 0.8924014653825698 26 O75844 1 +Abnormal posterior segment imaging 0.5893813907404644 0.6496469871534566 0.5159202745544009 1.0 0.8924014653825698 4 Q96S66 1 +Congenital onset 0.3359652569722509 0.6494184096135776 0.5160679678473796 1.0 0.8924014653825698 104 Q4J6C6,Q9HC21,P20674,Q9NQT5,Q13509,Q96N66,Q7LGA3,P55011,Q9UHX1,O43819,Q99567,Q96PU5,P07602,Q6NUK1,Q03252,Q5KU26,O14578,Q8TD16,Q8NFH4,P51571,P08670,Q15125,Q5XKP0,Q9Y263,Q9NZJ7,Q969X5,P12235,Q5H8A4,P46977,O00203 30 +Focal t2 hyperintense basal ganglia lesion 0.3699685339758176 0.6489692891460892 0.516358226801263 1.0 0.8924014653825698 21 P03886,Q96CU9,Q7KZN9 3 +Inappropriate antidiuretic hormone secretion 0.7194780987884435 0.648025231672696 0.5169686309792283 1.0 0.8924014653825698 2 P50336 1 +Elevated circulating growth hormone concentration 0.7191674433053634 0.6469201766951326 0.517683606662452 1.0 0.8924014653825698 2 P10644 1 +Pituitary prolactin cell adenoma 0.7191674433053634 0.6469201766951326 0.517683606662452 1.0 0.8924014653825698 2 P10644 1 +Adrenocorticotropic hormone deficiency 0.719167443305362 0.6469201766951281 0.5176836066624548 1.0 0.8924014653825698 2 P04637 1 +Increased circulating acth level 0.7191674433053608 0.6469201766951236 0.5176836066624577 1.0 0.8924014653825698 2 P16435 1 +Low back pain 0.7185461323392359 0.6447119010242117 0.5191139025288802 1.0 0.8924014653825698 2 Q8WVX9 1 +Genetic anticipation 0.718546132339223 0.6447119010241662 0.5191139025289098 1.0 0.8924014653825698 2 Q9UBB4 1 +Aplasia hypoplasia of the ribs 0.3603097512599137 0.6445111933811851 0.5192440015628115 1.0 0.8924014653825698 24 Q96HY6,O14656,Q8TAA9,Q96L58,Q12768,Q9UHX1,Q9Y619,Q14739 8 +Abnormal uvea morphology 0.3307137979242842 0.64432479974489 0.5193648373062327 1.0 0.8924014653825698 99 Q9BXW9,P52732,Q7LGA3,Q86YV9,Q9UHX1,P56589,Q10713,P40855,P40939,O43505,P10644,P14174,P04439,Q9Y4P3,Q99643,O96028,Q12768,Q13043,P49327,Q9UBM7,Q01968,O95202,Q96J42,Q9NR77,Q15056,Q15645,P21912,P50148,Q8IY17,Q5XKP0,Q9UNE7,Q05086,Q04721,P38398,P53701,Q5H8A4,O75381,Q9Y619,O00203 39 +Type i transferrin isoform profile 0.4400404785412151 0.6438682482190202 0.5196608730021599 1.0 0.8924014653825698 9 P51571 1 +Radioulnar dislocation 0.7015802150991985 0.6427469611877772 0.5203883036892951 1.0 0.8924014653825698 3 P16435 1 +Abnormality of the radioulnar joints 0.7015802150991985 0.6427469611877772 0.5203883036892951 1.0 0.8924014653825698 3 P16435 1 +Self mutilation 0.4311264438581192 0.6357107194560719 0.5249649883141085 1.0 0.8976156390927196 10 O75962,Q9UBM7,Q10713,Q96RL7 4 +Abnormal femoral head morphology 0.3723333839323407 0.6349034073815781 0.5254914146461693 1.0 0.8981803612037362 20 P16278,O95831,Q96DX4,Q96L58,Q7LGA3,O75431,Q04656 7 +Dysphagia 0.3594538491265821 0.6338877829000961 0.5261540591751925 1.0 0.8982080998339514 131 O60313,Q9UHX1,P55011,O43819,P53007,P03886,Q96RL7,Q12959,P07602,Q8IZA0,Q99643,P05067,Q13510,P35670,O15118,O76024,Q04656,Q01105,P20700,Q9NR77,Q69YQ0,P57678,P04062,P61916,Q99720,Q14108,P21912,Q14739,P50148,Q9UBB4,Q9Y263,Q9NZJ7,Q15233,O94905,Q9UEY8,Q9P0J1,P12235 37 +Clubbing of toes 0.6986725854247514 0.6327152115399418 0.5269196344771216 1.0 0.8982080998339514 3 P38398 1 +Duodenal stenosis 0.6986725854247514 0.6327152115399418 0.5269196344771216 1.0 0.8982080998339514 3 P38398 1 +Pyridoxine responsive sideroblastic anemia 0.6986725854247514 0.6327152115399418 0.5269196344771216 1.0 0.8982080998339514 3 P38398 1 +Progressive visual loss 0.3677893014408656 0.6324744349635659 0.5270769085507376 1.0 0.8982080998339514 21 O60313,P50897,O95140,O14773,O75503,P03886 6 +Hyperkalemia 0.5846552962754912 0.6315087549185846 0.5277079266205726 1.0 0.8982584218143942 4 Q13423 1 +Motor axonal neuropathy 0.3978958282220124 0.6282604309956672 0.52983334831942 1.0 0.8982584218143942 14 O60313,O15269 2 +Abnormal blood monovalent inorganic cation concentration 0.3827483549950305 0.6280401606135 0.529977631521696 1.0 0.8982584218143942 17 Q13423,P05023,P04637 3 +Hydrocele testis 0.4540442335785732 0.6275060693183744 0.5303275589856709 1.0 0.8982584218143942 8 Q9UBX3 1 +Oligohydramnios 0.3529406263633268 0.6261185223979714 0.5312372040034825 1.0 0.8982584218143942 36 P16435,P49366,Q6NUK1,Q96J42,Q9BXW9,Q96L58,P38398,Q7LGA3,Q9UHX1,P23786,O60566 11 +Synostosis of metacarpals metatarsals 0.696736962298284 0.6260611434588191 0.5312748373950575 1.0 0.8982584218143942 3 P16435 1 +Crumpled long bones 0.7132649891270562 0.6260418977423033 0.531287460475399 1.0 0.8982584218143942 2 P07237 1 +Aplasia hypoplasia involving the nose 0.3577061280930623 0.6254665207058991 0.5316649149691912 1.0 0.8982584218143942 27 O75844,P02545,Q5KU26,O75962,O75431 5 +Female infertility 0.7123330226778369 0.6227661578380455 0.5334382004306104 1.0 0.8986804708505389 2 Q15645 1 +Coxa vara 0.3966969008195867 0.6205748315256907 0.5348794037530467 1.0 0.898925296404749 14 Q96HY6,O95831,Q96AY3,Q9Y487,Q04656 5 +Elevated gamma glutamyltransferase level 0.5057954544175173 0.6205145950130121 0.5349190481437596 1.0 0.898925296404749 5 Q5XKP0 1 +Limited extraocular movements 0.4682417405871471 0.6155530654832227 0.5381895360216564 1.0 0.9019508380266866 7 O75306,O43819 2 +Optic nerve hypoplasia 0.3736370221962004 0.6153341706578795 0.5383340555420255 1.0 0.9019508380266866 19 P37268,Q9NVI7,Q9UHX1 3 +Gastrointestinal infarctions 0.7095371233302157 0.6129738607030087 0.5398936235618064 1.0 0.9029312158017392 2 O15460 1 +Glossitis 0.7095371233302157 0.6129738607030087 0.5398936235618064 1.0 0.9029312158017392 2 O15460 1 +Recurrent pharyngitis 0.7095371233302157 0.6129738607030087 0.5398936235618064 1.0 0.9029312158017392 2 O15460 1 +Weakness due to upper motor neuron dysfunction 0.3620080894525201 0.6125066084767322 0.5402026270467881 1.0 0.9030988788781464 136 Q9P0J0,O60313,O00400,Q9H9P8,O43681,Q7KZN9,Q9Y296,O75787,P03886,P07602,P17900,Q96CU9,P00403,Q13510,Q12768,P50416,Q13423,O95831,P20700,Q9NZ08,O95299,P04062,O75298,Q15041,P21912,Q9H6K4,Q5XKP0,Q9UBX3,P51572,P04637,Q9NZJ7,O94905,Q9Y619 33 +Abnormal tricuspid valve physiology 0.3729140656556835 0.6101186413641949 0.5417832188870113 1.0 0.9046327443945524 19 Q6NUK1,Q15904,P53701,P40939,O75431 5 +Subcutaneous nodule 0.3762640129650839 0.6074655674992715 0.5435419867154097 1.0 0.9060352228503316 18 Q9NZ08,P01889,P06280,P52732,Q99643,Q13510,Q15437,P49327,P21912,Q01968 10 +Eeg with spike wave complexes 0.4101529051982336 0.6045932352079834 0.5454493025987013 1.0 0.9078063929840752 12 Q14108,O75503 2 +Muscular hypotonia of the trunk 0.3094254544223712 0.6041062837853689 0.5457729820554518 1.0 0.9078063929840752 81 O60313,Q9NVI7,Q9HC21,Q9NQT5,Q96N66,Q96PU5,O00754,P07602,P17900,P20700,Q15043,P49366,Q5XKP0,Q9NZJ7,Q15233,O75880,Q9P0J1,O75306,Q2TAA5 19 +Spotty hypopigmentation 0.6899230631115734 0.6027954410292764 0.5466447799849017 1.0 0.9082316573116344 3 Q15125 1 +Episodic tachypnea 0.4811487587464929 0.6005912690423103 0.5481122546281929 1.0 0.910339504513056 6 Q10713 1 +Progressive cerebellar ataxia 0.349084709358149 0.6001681423729697 0.548394182802088 1.0 0.9104256496453688 37 Q9P0J0,Q9UBB4,Q96CU9,Q7KZN9,O95299,Q9NW15,Q9Y487,Q9Y619,O76024 9 +Developmental stagnation 0.448691716032501 0.5999166657657302 0.5485617749228155 1.0 0.9104256496453688 8 O43175 1 +Abnormality of lower limb metaphyses 0.5008390463299278 0.599134835188909 0.5490829735085092 1.0 0.9105786887568906 5 P04637 1 +Bladder diverticulum 0.4314972463348494 0.5972612821729947 0.5503329499838041 1.0 0.9105786887568906 9 Q04656,Q9Y4P3 2 +Rapidly progressive 0.4166329267792354 0.5964997166835646 0.5508414430785296 1.0 0.9105786887568906 11 Q14108 1 +Congenital hip dislocation 0.3539963254280565 0.5938834413167084 0.5525900748651833 1.0 0.9124810504174808 25 P57678,Q9Y487,Q9UHX1,P53007 4 +Abnormal shape of the palpebral fissure 0.4235465850981866 0.5931067273240079 0.553109728557998 1.0 0.9125707604226267 10 P38398,Q9UHX1 2 +Abnormal upper motor neuron morphology 0.4235112048053197 0.5929086530678715 0.5532422867292448 1.0 0.9125707604226267 10 Q99720,Q8IY17,P54886,O94905 4 +Head tremor 0.3922664746512347 0.5922477604486642 0.5536846916374345 1.0 0.9129716251378512 14 Q99720,P20700,Q96RL7 3 +Multiple joint contractures 0.3624154213445035 0.5919040910687792 0.5539148141391892 1.0 0.91302229443605 21 O75844,P02545,P51530,Q15043,Q96L58,Q96S52 6 +Migraine 0.3532892163839637 0.589411196009235 0.5555854677982008 1.0 0.9147881542783034 23 Q9NZ08,P00403,P05067,P12235,P03886 5 +Flared metaphysis 0.4459764602325524 0.5859846456129225 0.5578858331151775 1.0 0.9165982166610684 8 P48651,Q96HY6,Q14739 3 +Cns hypomyelination 0.3450259304223504 0.581901502165835 0.5606330286265737 1.0 0.9177037854043636 39 Q13144,O00400,O43175,Q8TB36,O75746,P51572,Q99720 7 +Decreased circulating copper concentration 0.571518692926431 0.5817220045740761 0.560753947273466 1.0 0.9177037854043636 4 Q15904 1 +Abnormality of the vertebral endplates 0.4766972607297296 0.5800990033916573 0.5618478557979842 1.0 0.9177037854043636 6 P51798,Q96L58 2 +Vertebral compression fracture 0.3757123292544049 0.5795022226213787 0.5622503473424383 1.0 0.9177037854043636 17 Q96HY6,Q96AY3,Q04721,P07237,P04062,Q14108 6 +Facial asymmetry 0.3491254109878929 0.5792790534707455 0.5624008968369325 1.0 0.9177037854043636 34 Q01105,Q8NCH0,P52788,O96028,P38398,Q9UHX1,O75962,O95202 8 +Abscess 0.4057755526417586 0.5784534185398047 0.5629580377938925 1.0 0.9177037854043636 12 Q5HYI8,P38398,P04637,Q8TAA9 4 +Decreased circulating progesterone 0.475822011509674 0.5760839294780317 0.5645584532834931 1.0 0.918335047099508 6 P16435 1 +Abnormal circulating progesterone level 0.475822011509674 0.5760839294780317 0.5645584532834931 1.0 0.918335047099508 6 P16435 1 +Lambdoidal craniosynostosis 0.6816365098011745 0.574849396677102 0.5653931559249181 1.0 0.9193662148367188 3 P16435 1 +Dilatation of the cerebral artery 0.4199368226130889 0.5729383679138211 0.5666864249848591 1.0 0.9204885207540512 10 P10253,P38435 2 +Renal cyst 0.2931426408779701 0.5725113977111572 0.5669755664231837 1.0 0.9205748839177432 64 Q9UHX1,P56589,Q10713,P40855,O60566,O43505,Q9UKG1,Q9UGP8,Q9Y4P3,Q9UBM7,Q86YH6,Q01968,Q16134,Q96J42,Q15056,Q15645,P23786,Q04721,Q53EZ4,O75381,P21964 21 +Abnormal nipple morphology 0.3017638072581481 0.5719680396674846 0.567343627161569 1.0 0.9205748839177432 61 Q6NUK1,Q2TAA5,P52788,Q96AA3,O96028,Q96A33,Q7LGA3,Q12768,P23786,Q5H8A4,Q9UBM7,O95202 12 +Recurrent paroxysmal headache 0.4122800160254314 0.5713816042955634 0.567740996056606 1.0 0.9205748839177432 11 P10644,P21912,P03886,P00403 4 +Abnormal hdl cholesterol concentration 0.5684209857154346 0.5701269096422567 0.5685916249155805 1.0 0.9205748839177432 4 P02545 1 +Hepatomegaly 0.3911950086786357 0.5697704429636063 0.5688334050226072 1.0 0.9205748839177432 177 Q9NVI7,Q9HC21,Q9BT22,Q96AA3,P54802,O75787,P09622,Q10713,P53007,P40855,P03886,P40939,O43676,Q96RL7,P16278,P07602,P09601,Q96CU9,P39210,Q13510,Q86Y39,P50416,P51798,P35670,O15118,P02545,P35573,P04062,P61916,O96000,Q9Y6M9,Q14108,O75431,P23786,Q14739,P33991,Q96HY6,Q9UJS0,Q15904,Q9NZJ7,P10253,Q96A33,O75880,O75381,Q9Y619,O00203 46 +Limitation of neck motion 0.6801071018251308 0.5697351365320753 0.5688573549351046 1.0 0.9205748839177432 3 P02545 1 +Hyperorality 0.5681185687257834 0.5689980554239532 0.5693574596016515 1.0 0.9205748839177432 4 Q05086 1 +Perseveration 0.4584701225964325 0.5680918815024759 0.5699725801040967 1.0 0.9205748839177432 7 P61916,Q9UQN3,Q15233 3 +Gingival overgrowth 0.3505449410773305 0.5671807886092458 0.5705913589794029 1.0 0.9205857543610264 27 P50148,P10644,O00754,P16278,P20700,Q9Y4P3,Q9UM00,Q9UBM7,Q14739 9 +Emg myopathic abnormalities 0.3482175440849074 0.5660291077449369 0.5713739934863857 1.0 0.9205857543610264 33 P02545,P07196,P50402,P13473,P12235 5 +Symphalangism affecting the phalanges of the hand 0.6789924740580093 0.5660166822515105 0.5713824401199912 1.0 0.9205857543610264 3 P48651 1 +Proximal symphalangism 0.6789924740580093 0.5660166822515105 0.5713824401199912 1.0 0.9205857543610264 3 P48651 1 +Limitation of joint mobility 0.3288842946550023 0.5638140716420469 0.5728806741717092 1.0 0.9219425301273892 104 Q9BTV4,Q9HC21,Q15427,Q9BT22,P54802,Q9UBC1,Q7LGA3,O00754,P16278,P50402,Q9Y4P3,Q96L58,O14656,P51648,O15460,P48651,Q8WVM7,Q04656,O76024,O75844,Q01968,P02545,P16435,Q8TD16,Q96DX4,Q8TAA9,Q8WXH0,Q15056,Q53GS7,O75431,P23786,Q9H6K4,Q05086,O95140,Q96AY3,P37268,O14979,P15586,O94905,Q969X5 40 +Developmental regression 0.3437811730343917 0.5638085071278778 0.5728844615602495 1.0 0.9219425301273892 120 Q9H9P8,O43681,O43819,P40855,P03886,P16278,P07602,P17900,Q9Y4P3,P06280,Q13510,O95470,Q04656,O76024,O95831,Q9NZ08,P13073,Q96IX5,Q15043,O75503,P21912,Q13144,Q9NVH6,Q9NZJ7,O75381 25 +Hypoplastic nipples 0.4108177399952283 0.5629715979168572 0.5734542243106935 1.0 0.9220148716875288 11 Q96A33 1 +Abnormality of the glabella 0.4414102612532811 0.5626594226227766 0.5736668201436492 1.0 0.9220148716875288 8 O95202 1 +Cerebellar malformation 0.3062614762261142 0.561858115964219 0.5742126923454318 1.0 0.9222447977024668 59 Q9NQT5,Q99567,O43505,O60566,O00754,O43175,Q9Y4P3,Q12768,Q9UBM7,P16435,Q96J42,P36543,Q15043,Q8TAA9,Q15056,Q15645,Q15125,P23786,P50148,Q15233,Q9Y487 21 +Aplasia hypoplasia involving the metacarpal bones 0.349848128370596 0.5615259768383507 0.5744390267567439 1.0 0.922284818905726 27 P16435,P10644,Q9BXW9,Q9NX62,Q96DX4,Q96L58,Q96S52,P51812,O75962,Q14739 10 +Aplasia hypoplasia of the earlobes 0.4104720974900396 0.5609858409267285 0.5748071895957076 1.0 0.9223027861188132 11 P21964 1 +Triangular mouth 0.4569825304494165 0.5609185586535189 0.5748530577818505 1.0 0.9223027861188132 7 Q10713 1 +Abnormality of the nasal skeleton 0.565677873187086 0.5599082546419226 0.5755420180415576 1.0 0.9227615198222312 4 Q6NUK1 1 +Increased urine alpha ketoglutarate concentration 0.4912104793611825 0.5580140016519235 0.5768348231153855 1.0 0.9238638177843128 5 P09622 1 +Recurrent acute respiratory tract infection 0.676054308337984 0.5562508872043451 0.5780393563026291 1.0 0.9251458275112684 3 Q03519 1 +Pectus carinatum 0.3456824318869405 0.5557037921486533 0.5784133637841753 1.0 0.9254209618335916 35 O00754,Q9NVI7,P16278,Q9Y263,Q96AY3,P52788,Q96L58,P51812,P55011,Q9Y619,P53007,Q04656 12 +Focal emotional seizure 0.4235908370849935 0.5545187642077847 0.5792238675385828 1.0 0.926070561962001 9 O43175 1 +Male reproductive system neoplasm 0.3860834967430421 0.5529299098002938 0.5803114056320473 1.0 0.9260810716857258 14 Q13423,P10644,P04637 3 +Esodeviation 0.3445324273956514 0.5524411297364092 0.5806461578531816 1.0 0.9260810716857258 36 Q9NVI7,P20700,O43175,Q5KU26,P04062,Q9UHX1 6 +Hydrops fetalis 0.3389992707391558 0.547749548446649 0.5838638849969215 1.0 0.9286254704414394 41 Q9BT22,P04062,Q13510,P10619,P40939,Q14739 6 +Difficulty running 0.400291651755948 0.5458854802000965 0.58514465975866 1.0 0.9295446613159368 12 Q9BPX6,Q8TD16,P07196 3 +Aplasia hypoplasia of the patella 0.5614177479010425 0.5441329498013344 0.5863499877488014 1.0 0.9296457890279136 4 Q9Y619 1 +Increased vertebral height 0.6721566190180146 0.5433781959386638 0.5868694349936439 1.0 0.9296457890279136 3 O00754,Q04721 2 +Diaphragmatic weakness 0.487477941209269 0.5422316334917496 0.5876589458537278 1.0 0.9297766618751672 5 Q9NR77 1 +Skin erosion 0.4369322203273524 0.5399198914498363 0.5892522793666126 1.0 0.93122598383984 8 O75844,P02545 2 +Radioulnar synostosis 0.3554733207944611 0.5397594433070471 0.5893629397614886 1.0 0.93122598383984 21 O96028,Q9Y4P3,O95202 3 +Motor deterioration 0.4863628985757567 0.537535060756532 0.5908980734053726 1.0 0.9326256504562088 5 O75503 1 +Decreased facial expression 0.3460956356565618 0.5364905299238903 0.5916195791522993 1.0 0.9326256504562088 30 Q9Y263,P51530,Q15043,P04062,O75787,Q969X5,Q53GS7,P12235,Q04656 9 +Choanal stenosis 0.5591904112706787 0.5359322271524716 0.5920053905847755 1.0 0.9328261126936294 4 P16435,P48651 2 +Tracheal stenosis 0.5590689008227034 0.5354857940810225 0.5923139782788513 1.0 0.9328533083912828 4 Q15125,Q9UBM7 2 +Skeletal myopathy 0.4858357858522757 0.5353178309468895 0.5924300984498472 1.0 0.9328533083912828 5 P40939 1 +Gaze evoked nystagmus 0.4357477866085653 0.5339290248311397 0.5933906399927982 1.0 0.9335442280362034 8 Q9UBB4,Q9UNE7,Q10713 3 +Bilateral cryptorchidism 0.4197295434772553 0.533799140684204 0.5934805083671955 1.0 0.9335442280362034 9 P36543,P37268,Q15233 3 +Recurrent bronchitis 0.5582235832560164 0.5323828199898468 0.5944608815701815 1.0 0.93433607281561 4 Q03519 1 +Abnormal nervous system electrophysiology 0.3909438415176806 0.5321876283217802 0.5945960507064179 1.0 0.93433607281561 181 O60313,O43681,P07196,Q96N66,O14773,O15269,P53007,P40855,P03886,Q6UWE0,Q9NZ01,Q96RL7,P50897,P07602,O43175,P00403,O96028,P39210,O95202,P02545,O95831,P20700,Q9NR77,Q8TB36,P13073,O75503,Q99720,Q15125,Q14108,Q9UBB4,Q9Y263,O95140,Q9UBX3,P52788,Q9NZJ7,Q96A33,Q9Y619,Q5H8A4,O75381,P21964,Q2TAA5 41 +Megalencephaly 0.6679605067740718 0.5296277794884103 0.5963700299146246 1.0 0.9344122511332332 3 P52788 1 +Adenocarcinoma of the small intestine 0.6843740292016128 0.527373624225741 0.5979341560612157 1.0 0.9353231683905486 2 P78549 1 +Duodenal adenocarcinoma 0.6843740292016128 0.527373624225741 0.5979341560612157 1.0 0.9353231683905486 2 P78549 1 +Synostosis of joints 0.3422144193363701 0.5257129322149257 0.5990876771049811 1.0 0.9353231683905486 35 P16435,Q9Y4P3,Q96L58,O96028,Q8TAA9,Q15233,Q9UHX1,P48651,Q04656,O95202 10 +Unconjugated hyperbilirubinemia 0.6666613620814636 0.5253937539588276 0.5993094946621249 1.0 0.9353231683905486 3 P11413 1 +Chromosome breakage 0.4112947599253602 0.5250152666668932 0.5995725781040959 1.0 0.9354149353112964 10 P38398,P13073,P33991 3 +Hypohidrosis 0.4108619595976656 0.5226297678386637 0.6012319210616033 1.0 0.9354235743798268 10 P06280 1 +Kyphosis 0.3694320795918572 0.522503294313248 0.6013199533585745 1.0 0.9354235743798268 154 Q9BTV4,P34059,Q13509,Q9BT22,P51530,Q9Y296,Q7LGA3,Q9UHX1,P55011,P53007,Q99567,P10644,O00754,P16278,P50402,Q9Y4P3,Q96L58,Q99643,Q5KU26,O96028,O14656,Q12768,P51648,P48651,Q9UBM7,Q04656,O95202,O75844,Q01968,P02545,O95831,Q9NR77,Q8TB36,P36543,Q8TD16,O75648,Q96DX4,P04062,P51812,Q8WXH0,Q15056,Q53GS7,Q14108,Q15125,P21912,Q14739,Q9NWM8,Q9Y263,O95140,Q96AY3,Q8NCH0,Q04721,P52788,P07237,Q15233,O94905,Q9Y487,Q5H8A4,O75962,Q32P28 60 +Abnormal bone structure 0.3877830143042778 0.5207674535759775 0.6025287782155586 1.0 0.935599499991866 178 Q9HC21,P38435,Q9BXW9,Q15392,Q86XL3,P54802,P40855,O60566,P10644,O00754,P16278,P07602,O43175,Q6NUK1,Q9Y4P3,Q96L58,P06280,O96028,Q13510,P48651,P51798,Q9UBM7,P35670,Q04656,O95202,O75844,P02545,Q5JRA6,O95831,P57678,Q15043,P04062,Q15645,Q14108,Q15125,O75431,P21912,Q14739,Q9UG56,Q9NWM8,Q96HY6,P12235,P04637,P52788,Q9NZJ7,P38398,O00116,Q9Y487,Q13126,Q5H8A4,O75381,Q9Y619 52 +Cessation of head growth 0.4483920306061112 0.519791344036558 0.6032090130648284 1.0 0.935717344294956 7 Q13144,Q9Y263,Q05086 3 +Pruritus 0.34458023624744 0.5194646295024559 0.603436772241261 1.0 0.935717344294956 24 P22830,Q96A33,P16615,P35670,Q14739 5 +Slow decrease in visual acuity 0.4483209464396334 0.5194532469372849 0.6034447079499903 1.0 0.935717344294956 7 O95140,P03886 2 +Abnormality of ocular smooth pursuit 0.3485895212771536 0.5187213140396171 0.6039550961785369 1.0 0.9360223354296882 22 Q9UBB4,Q9NW15,O14773,Q10713,P46977 5 +Colon cancer 0.3696448551179625 0.5173795844406687 0.6048912083069635 1.0 0.9364254703044071 16 P10644,P04637,Q5HYI8,P38398,Q15645 5 +Cystic liver disease 0.5531546729223333 0.5138786631422756 0.6073368260282643 1.0 0.93788000737403 4 Q96J42 1 +Adrenal hyperplasia 0.5530089696770275 0.5133494214718984 0.6077069189514626 1.0 0.93788000737403 4 P16435 1 +Abnormality of dental color 0.5524843494950965 0.511445078227686 0.6090394367850709 1.0 0.938306274105412 4 P16278,Q6P4Q7 2 +Abnormal male reproductive system physiology 0.3405576586670264 0.5114188478744154 0.6090577999101667 1.0 0.938306274105412 35 P16435,O75298,P20700,Q9Y4P3,P38398,P04062,Q13423,O76024 8 +Exodeviation 0.3433703251681034 0.5113600676132388 0.6090989511955338 1.0 0.938306274105412 23 Q05086,Q13509,Q15233,Q9UEY8,Q9UHX1,O43819,Q8NB90,P40939 8 +Abnormal peripheral nervous system morphology 0.3684704110227247 0.5111329476634789 0.6092579664982267 1.0 0.938306274105412 154 O60313,Q9NVI7,Q9HC21,O43681,P07196,Q9UHX1,O43819,O15269,P53007,P40855,P03886,Q6UWE0,Q96RL7,P10644,P07602,P00403,P39210,Q13510,P48651,P51798,Q04656,O76024,P02545,O95831,P20700,Q9NR77,Q8TB36,Q9BQT8,Q15043,P51812,Q99720,Q9BPX6,P21912,Q9UBB4,Q9NZJ7,Q8IV08,P12235,O75381,Q9Y619 39 +Limited wrist extension 0.6794035414725039 0.5110463937094532 0.6093185710672608 1.0 0.938306274105412 2 Q9Y223 1 +Abnormality of lens shape 0.679403541472501 0.511046393709443 0.6093185710672679 1.0 0.938306274105412 2 Q01968 1 +Upper limb asymmetry 0.6790928859894324 0.5100327492170164 0.6100285184171428 1.0 0.9385955265014472 2 Q15555 1 +Hepatic fibrosis 0.3414403889436387 0.5084628934117269 0.6111287554829126 1.0 0.9385955265014472 33 Q96J42,Q9UJS0,Q15904,P04062,Q13510,Q10713 6 +Abnormality of skeletal muscle fiber size 0.3585891846276443 0.5074958033122018 0.611806980268156 1.0 0.9385955265014472 19 O60313,P02545,O95831 3 +Ulnar deviation of the wrist 0.4790757689136969 0.5070577454333216 0.612114301888879 1.0 0.9385955265014472 5 P16435,P16278,P34059 3 +Tics 0.4303229170165371 0.5066244071839443 0.612418379601591 1.0 0.9385955265014472 8 Q9UHX1 1 +Emotional lability 0.3130328124329635 0.5059595507359029 0.6128850456954198 1.0 0.9385955265014472 54 Q9P0J0,P10644,Q15165,P07602,O43681,Q96CU9,Q7KZN9,O95299,Q9NZJ7,Q96RL7 10 +Conical tooth 0.4600674808789307 0.5046869285504926 0.6137787433934658 1.0 0.9392177994227672 6 Q9Y487 1 +Abnormal vitreous humor morphology 0.4449735467731008 0.5035757160098059 0.6145595609272467 1.0 0.9392751099752544 7 P04439,P53701 2 +Follicular thyroid carcinoma 0.5495541949564109 0.5008450923015286 0.6164801478296913 1.0 0.9410642567131012 4 Q99643,P21912 2 +Heinz bodies 0.6753650201925983 0.4979326833360075 0.6185314900353327 1.0 0.9416040988584308 2 P11413 1 +Aplasia hypoplasia of the palmar creases 0.6568463151263939 0.4937732835633643 0.6214663031941821 1.0 0.9437281691049254 3 Q8NCH0 1 +Abnormal ilium morphology 0.3492045224519526 0.4929874414448029 0.6220214610188641 1.0 0.9437281691049254 21 O00754,P16278,O95831,Q96L58,Q8TAA9,P51812,Q04656 7 +Abnormality of the posterior pituitary 0.4053578272751386 0.4924241373218398 0.6224195393528882 1.0 0.9437281691049254 10 Q9UHX1 1 +Cerebral hypomyelination 0.3626831715616644 0.4905558714396644 0.6237406040361786 1.0 0.944519083578386 17 Q13144,P51572,O43175 3 +Cerebellar atrophy 0.354281994120994 0.4901497636332051 0.6240279262714223 1.0 0.944519083578386 139 O60313,O00400,Q9NVI7,Q9H9P8,Q9NQT5,Q9BT22,Q9Y296,Q9NW15,O14773,O75787,Q10713,Q92643,O00754,Q96CU9,Q9Y320,P51798,P13073,Q15043,O75503,O75208,Q14108,Q9H6K4,Q9UBB4,Q5XKP0,Q9Y263,P51572,Q8IV08,P51970,P12235,Q5H8A4,P46977 31 +Melanoma 0.3448174147203919 0.4899365409301093 0.6241788047408159 1.0 0.944519083578386 22 P50148,P04637,Q5HYI8,Q99643,P38398,P21912 6 +Cardiomegaly 0.3377924310497106 0.4876143094131807 0.625823058027912 1.0 0.9450873787999562 35 P10644,P20674,Q9Y4P3,P54802,Q15233,P04062,P10253,Q96S52,P50416,P13473,P23786,Q14739,Q86YH6 13 +Smooth muscle antibody positivity 0.6719478098788408 0.4869458248985995 0.6262967233179404 1.0 0.9450873787999562 2 P49327 1 +Bilateral tonic clonic seizure 0.3036568407878071 0.4838899769871698 0.6284639540311576 1.0 0.9450873787999562 85 Q5H8A4,Q9HC21,P07602,O43175,Q01105,Q9Y320,Q9NZJ7,P00403,P04062,O75787,Q13510,P03886,Q14739,Q96RL7 14 +Abnormal electroretinogram 0.3394023283866556 0.4838731693177203 0.6284758830412462 1.0 0.9450873787999562 31 P40939,P50897,Q53H12,Q96S66 4 +Abnormal metabolism 0.3127233859451117 0.4807344456178334 0.6307052465068566 1.0 0.9452347842210518 53 Q8N511,Q9BT22,Q15904,Q96AA3,Q9Y487,P51571,P46977 7 +Osteoporosis 0.2857771402817927 0.4794567776532109 0.6316137098056647 1.0 0.9452347842210518 68 P16278,Q9HC21,P02545,O43175,Q9Y4P3,O96028,Q13510,P12235,Q5H8A4,P35670,Q04656,O95202 12 +Natal tooth 0.4398319399174468 0.4793612364930931 0.6316816650488255 1.0 0.9452347842210518 7 O75844 1 +Abnormal waist to hip ratio 0.4396496369271555 0.4785066893045951 0.6322896143413588 1.0 0.9452347842210518 7 Q9Y6M1,P31751,O76024 3 +Patchy hypopigmentation of hair 0.5429937443073787 0.4773423871215002 0.6331183322960634 1.0 0.9460804113150342 4 P02545 1 +Meningocele 0.395728173816592 0.4771314794623221 0.6332684998210483 1.0 0.9460804113150342 11 P21964,Q10713 2 +Abnormality of central nervous system electrophysiology 0.3596636171821026 0.4745543841222301 0.6351046261802933 1.0 0.9468245094331468 147 O60313,P07196,Q96N66,P40855,P03886,Q9NZ01,P50897,P07602,O43175,P00403,O96028,O95202,P20700,P13073,O75503,Q15125,Q14108,Q9UBB4,Q9UBX3,Q9NZJ7,Q96A33,Q5H8A4,O75381,P21964 24 +Abnormality of the intrinsic pathway 0.4084156147117891 0.4737587576333869 0.6356719477246693 1.0 0.9468245094331468 9 Q9Y487 1 +Diminished motivation 0.3388863321437083 0.4735310930804585 0.6358343233253825 1.0 0.9468245094331468 25 Q9UBB4,P04062,Q96RL7,P17900 4 +Contractures of the joints of the lower limbs 0.3052076239443981 0.4693336007962084 0.6388312014427973 1.0 0.9506688564857226 56 O60313,Q99720,P02545,Q9HC21,P50402,Q8IZA0,Q96AY3,Q8TD16,P37268,O94905,Q86XL3,Q7LGA3,Q8WXH0,P48651,Q8N2K0,P23786,P21912 17 +Red green dyschromatopsia 0.6488636060184669 0.4685563822630653 0.639386760817455 1.0 0.9511864775123868 3 Q9H6K4 1 +Abnormal adipose tissue morphology 0.3003886092659595 0.4676292704378652 0.6400497292406684 1.0 0.9518634979516144 58 O75844,P02545,Q6NUK1,O43175,P50402,O95140,Q2TAA5,Q03252,Q99643,Q8TAA9,Q8WXH0,Q9Y487,O75431,P21912,P42167 15 +Abnormality of upper limb joint 0.3338417165170534 0.4667651657134431 0.6406679007690896 1.0 0.9521643354825255 118 Q9BTV4,P34059,Q15427,P07196,Q15392,Q13509,Q9ULH0,Q7LGA3,Q99567,P10644,P16278,O43175,P50402,P42892,Q8IZA0,Q9Y4P3,Q96L58,O96028,O14656,Q13510,P48651,Q8WVM7,Q04656,O95202,O75844,Q01968,P02545,P16435,O95831,Q9NR77,Q96DX4,Q8WXH0,Q15056,Q53GS7,Q15125,P23786,Q9H6K4,Q96AY3,P37268,Q04721,O94905,Q15233,Q969X5,Q9Y619 44 +Male pseudohermaphroditism 0.5395802044863363 0.4652440050320752 0.6417567289828239 1.0 0.9528731374754716 4 Q96J42 1 +Increased circulating cortisol level 0.647332764964876 0.4637741131173037 0.6428095919767922 1.0 0.9528731374754716 3 P04637 1 +Urinary incontinence 0.3246921213237244 0.4629003088480359 0.6434358261246018 1.0 0.9531728177741318 45 Q9UBB4,P07602,P07196,O43681,Q9NZJ7,Q12768,O75298,Q99720,O75962 9 +Abnormal aortic valve cusp morphology 0.3371269254054921 0.462643470985124 0.6436199437342593 1.0 0.9531728177741318 23 P37268,Q9UHX1,Q9Y4P3 3 +Abnormality of the cheek 0.2948983714215316 0.4616732479141903 0.6443156582912868 1.0 0.9535621846528126 60 P02545,Q96J42,O96028,Q12768,Q9UHX1,Q9Y487,Q04656,O95202 8 +Ectopia lentis 0.4056491261427801 0.4592455633400586 0.64605783440987 1.0 0.954163868846838 9 Q03519,Q03518,Q96L58 3 +Fat malabsorption 0.3991960956843294 0.4589211685899538 0.6462907767636188 1.0 0.954163868846838 10 Q96A33 1 +Aplasia cutis congenita 0.3924577276659802 0.4587840662097607 0.6463892380788145 1.0 0.954163868846838 11 Q5H8A4,O95202 2 +Abnormality of lower limb joint 0.3786038061215945 0.456395623744368 0.6481055121298254 1.0 0.9563890235393072 173 Q9BXW9,Q9NQT5,Q9NX62,Q86XL3,Q7LGA3,Q9NW15,P55011,Q9UHX1,O75787,P53007,Q96PU5,O00754,P16278,P07602,Q9Y4P3,O14656,O96028,Q03252,Q13510,P48651,P51798,Q9UBM7,Q04656,O95202,O75844,P16435,P02545,Q5JRA6,O95831,Q9NR77,P57678,Q8TD16,Q15043,O75298,Q15041,Q15125,O75431,P23786,P21912,Q96HY6,O95140,P37268,Q9NZJ7,O94905,P38398,Q96A33,Q9Y487,Q9Y619,P21964,O00203 50 +Craniofacial hyperostosis 0.4486191785719612 0.4539828429303574 0.6498411756679763 1.0 0.9575727709995177 6 P48651,P51812 2 +Abnormal circulating bilirubin concentration 0.3364800837555067 0.4537887109785083 0.649980909664281 1.0 0.9575727709995177 27 P28288,Q9UJS0,O75648,P40855,P11413,P23786,Q14739 7 +Impaired visuospatial constructive cognition 0.4194337789942265 0.4525455321231679 0.6508760274800776 1.0 0.9576996561154484 8 P03886,Q10713 2 +Ileus 0.5352813179981436 0.4501400937697496 0.6526094285976771 1.0 0.9586637599216916 4 P50336,Q01844,P16930 3 +Elevated urinary delta aminolevulinic acid 0.5352813179981435 0.450140093769749 0.6526094285976776 1.0 0.9586637599216916 4 P50336,P36551,P16930 3 +Glomerular deposits 0.6601429015222077 0.4497931573547442 0.652859592217329 1.0 0.9586637599216916 2 P52565 1 +Petechiae 0.3837201412352429 0.4489335354748034 0.6534796034110764 1.0 0.9586637599216916 12 P04062,P51798 2 +Abnormal left ventricular outflow tract morphology 0.5348774884462247 0.4487290117265767 0.6536271535417293 1.0 0.9586637599216916 4 Q15645 1 +Subvalvular aortic stenosis 0.5348774884462247 0.4487290117265767 0.6536271535417293 1.0 0.9586637599216916 4 Q15645 1 +Brisk reflexes 0.3392485556006872 0.4476869958311417 0.6543791080898615 1.0 0.9586637599216916 22 P20674,Q5JRX3,O00483,Q9NW15,Q10713,Q53GS7,Q99720 7 +Retinal dysplasia 0.4470870288766108 0.4472817114315058 0.6546716700753723 1.0 0.9586637599216916 6 P53701,O43505,Q10713 3 +Gait imbalance 0.3390133530091966 0.4459096471169382 0.6556625133943585 1.0 0.9589271814501772 22 Q9UBB4,Q9NR77,Q9Y4P3,O15269,Q5H8A4 5 +Progressive muscle weakness 0.3689931177200608 0.4458726567561794 0.6556892345753451 1.0 0.9589271814501772 14 P40855 1 +Peripheral neuropathy 0.37307072962156 0.4448591100139863 0.65642157415455 1.0 0.9590792559201292 167 Q9P0J0,O60313,Q9NVI7,Q9HC21,O43681,P07196,Q7KZN9,P54802,O15269,Q9Y2R0,O43819,Q10713,P05023,P03886,P40939,P53007,Q16836,Q96RL7,P10644,P07602,Q96CU9,P00403,Q5KU26,P39210,O15460,O95470,P35670,O76024,O95831,Q9NR77,Q8TB36,O95299,Q15041,Q9BPX6,O95140,Q9NZJ7,Q8IV08,P12235 38 +Abnormality of the basal ganglia 0.2982296526496309 0.4424149704850598 0.6581889478658507 1.0 0.9599345676276392 83 Q9P0J0,O60313,P16278,O95831,Q96CU9,Q96AA3,Q7KZN9,P00403,Q96N66,P04062,O95299,O43819,P03886,Q9NZ01,P23786,Q96RL7 16 +Congestive heart failure 0.2879999606859554 0.4424123745822396 0.6581908259986327 1.0 0.9599345676276392 62 P16278,P02545,Q70HW3,Q9Y4P3,P00403,P06280,P10253,O75880,O43819,P03886,P40939 11 +Hypoplastic fingernail 0.3582195468611008 0.4419084963007738 0.658555422201395 1.0 0.9599345676276392 16 P48651,O75431,Q12768,Q14739 4 +Lipoatrophy 0.3492692454490829 0.4416602308465472 0.6587350919592103 1.0 0.9599345676276392 19 P02545,O75431,Q6NUK1,P42167 4 +Specific learning disability 0.2805602287842907 0.4411739083841453 0.6590871007086005 1.0 0.9599345676276392 66 Q04656,P10644,P00403,P53701,Q9Y619,Q10713,Q9H6K4,P48651,P21964,O75962,P03886 11 +Abnormality of earlobe 0.3343684615612058 0.4399479777465698 0.6599747858976537 1.0 0.9599345676276392 30 P16435,Q15392,Q7LGA3,P53701,P21964 5 +Dilated fourth ventricle 0.328189235303731 0.4398807527263675 0.6600234767816437 1.0 0.9599345676276392 40 O43175,Q96J42,Q12768,Q9Y487,Q10713,Q15645,Q15125,P23786 8 +Patent ductus arteriosus 0.3039186632321108 0.4386115215330314 0.6609430472191611 1.0 0.9599345676276392 89 O75844,Q96PU5,P02545,O43175,Q15392,P42892,Q9UHX1,P51571,P40855,P21964 10 +Neonatal onset 0.3375647563114172 0.4349765830996835 0.6635794248184348 1.0 0.961444805905318 22 Q8TB36,P40939,Q15904 3 +Deformed sella turcica 0.5308114412891002 0.4345971891925393 0.6638548356242959 1.0 0.961444805905318 4 O75431 1 +Reduced natural killer cell count 0.4610547897493589 0.433470120997299 0.6646732682017731 1.0 0.961444805905318 5 O00203 1 +Abnormal natural killer cell morphology 0.4610547897493589 0.433470120997299 0.6646732682017731 1.0 0.961444805905318 5 O00203 1 +Synostosis involving digits 0.5304117789972358 0.4332156937721892 0.664858078604633 1.0 0.961444805905318 4 P48651 1 +Agnosia 0.4152441385068549 0.4320249278854334 0.6657232956665289 1.0 0.961444805905318 8 P05067,O75787 2 +Impaired distal vibration sensation 0.4145905669590438 0.4288392205415371 0.6680402343189562 1.0 0.9622385130375908 8 P20700 1 +Premature loss of primary teeth 0.6341107922851649 0.4232228246833862 0.6721326953462847 1.0 0.9657030473770436 3 P51798 1 +Abnormal urine cytology 0.3278185190954465 0.4204925997767764 0.6741256343121975 1.0 0.9682626347288432 38 P10644,P09601,P06280,Q03252,P04062,O15460,Q15645,Q14108 8 +Abnormality of cranial sutures 0.3042083511125066 0.4182553348850336 0.6757604422080767 1.0 0.969684926705717 91 Q9NX62,P40855,Q9UM00,O00754,Q6NUK1,Q96L58,P48651,P51798,Q04656,O75844,P16435,P02545,O95831,P51812,O75431,Q8NCH0,Q9Y487,P21964,O75381,Q9Y619 20 +Cerebellar cyst 0.3274981936718816 0.4176887422933167 0.6761747042959936 1.0 0.969684926705717 38 O43175,O43505,Q96J42,Q9NQT5,Q12768,Q9Y487,P23786,Q15645,Q15125,Q99567,Q9UBM7,O60566 12 +Renal tubular atrophy 0.525645010879707 0.416845469832623 0.6767914413801668 1.0 0.9702655009642404 4 Q9NQH7,Q96AX1,P57740 3 +Hyperthyroidism 0.377786352266796 0.4148570759744395 0.6782465340321402 1.0 0.9707606819409402 12 P21964 1 +Pectus excavatum 0.2979485653631663 0.4146377434542811 0.6784071136488639 1.0 0.9707606819409402 85 Q7LGA3,Q9UHX1,O00754,P50402,Q9Y4P3,Q96L58,Q99643,Q04656,P02545,Q69YQ0,P04062,P51812,O75431,P21912,Q8NCH0,P52788,Q96A33,Q9Y487,O75962 19 +Retinal atrophy 0.3314184602485161 0.4144572288771828 0.6785392844945402 1.0 0.9707606819409402 29 P04439,Q9Y296,P04062,Q7LGA3,P55011,P51648,Q10713 7 +Short ribs 0.3907266892010522 0.4134715128407389 0.6792611895883738 1.0 0.971069930416848 10 Q96HY6,Q14739,Q9Y619 3 +Micronodular cirrhosis 0.4391272017941329 0.4128175027506918 0.6797403269002518 1.0 0.9714516095119392 6 P04637 1 +Oral pharyngeal dysphagia 0.3703624395106007 0.4108504883464383 0.6811821693227937 1.0 0.9720924472808506 13 Q13510 1 +Postural instability 0.3505999339812409 0.4094957572622386 0.6821758797467115 1.0 0.9720924472808506 17 P04062,O75503 2 +Pace of progression 0.3597345611078009 0.4082331443001019 0.6831025169797325 1.0 0.9720924472808506 154 Q9P0J0,O60313,O00400,P07196,P51530,P54802,O75787,Q10713,P05023,Q6UWE0,Q96RL7,P50402,Q03252,P39210,Q13510,Q12768,O95470,Q04656,P02545,O95831,P20700,Q9NR77,Q8TB36,Q15043,O00584,P04062,Q9Y6M9,O75298,Q99720,Q14108,P12235,Q5XKP0,O95140,O14979,O94905,Q8IV08,Q13126 37 +Ocular pain 0.5229453356116939 0.407663401525395 0.6835208102231867 1.0 0.9720924472808506 4 Q15043 1 +Vascular neoplasm 0.3254994549938587 0.407612353295992 0.6835582935114801 1.0 0.9720924472808506 39 P16435,O96028,Q7LGA3,Q12768,Q9UHX1,P10619,Q5H8A4,Q9UBM7,O95202 9 +Abnormal circulating albumin concentration 0.3294405416054477 0.4075753980720967 0.6835854291863592 1.0 0.9720924472808506 33 Q9BT22,O95470,Q5XKP0 3 +Abnormal retinal morphology 0.4026793352539113 0.4067162131503175 0.6842164311299066 1.0 0.9726876864774424 214 Q9P0J0,O60313,P38435,Q9NQT5,Q7KZN9,Q9Y296,Q7LGA3,O14773,Q9UHX1,P55011,O43819,P10619,P40855,Q9UM00,P03886,P40939,Q10713,Q16836,Q5T8D3,O00754,P50897,P07602,P16278,P17900,P04439,Q96CU9,Q9Y4P3,P00403,O96028,Q13510,Q12768,P51648,O95202,O76024,P02545,Q5JRA6,Q96J42,Q9NZ08,O95299,P04062,P51812,O75503,Q9Y619,Q6P4Q7,P21912,Q9UG56,Q9NW15,Q5XKP0,P04637,Q8NCH0,Q9NZJ7,P06865,P53701,Q9Y487,Q96S66,Q5H8A4,O75381,P21964 58 +Dolichocephaly 0.3292764726979313 0.406207351308117 0.6845902530737193 1.0 0.9727716714843128 33 Q4J6C6,Q9BXW9,Q04721,Q03164,O96028,P38398,Q969X5,P56589,P40855,Q5H8A4,O75381,O95202 12 +Squamous cell carcinoma 0.3500818485441913 0.4060574450632223 0.6847003924861192 1.0 0.9727716714843128 17 P02545,P53634,P53602,Q99828,P14324 5 +Tongue atrophy 0.5207943251615099 0.4003947887558407 0.6888657619238512 1.0 0.9771735823572844 4 P07196 1 +Profound sensorineural hearing impairment 0.520243890071135 0.3985416194534908 0.6902309857819557 1.0 0.9786855823202376 4 Q9NR77 1 +Dysphasia 0.3456446347553096 0.3952806503647384 0.692635777911649 1.0 0.9800924681883316 18 Q9H9P8,P21964 2 +Agammaglobulinemia 0.6418142280211185 0.3947361106615477 0.6930376499330029 1.0 0.9803457382946954 2 Q9NRZ9 1 +Prominent occiput 0.3531803739873234 0.3936801222257842 0.6938172188542204 1.0 0.9805384101283589 15 Q04656,Q12768,O43175,O14656 4 +Skin rash 0.342350755906096 0.393403320385406 0.6940216176514546 1.0 0.9805384101283589 19 Q99643,P28070,Q06136,P21912,Q14739 5 +Aplasia hypoplasia of the optic nerve 0.3315862378882649 0.390117886509023 0.6964493771201625 1.0 0.9827555309193294 22 P37268,Q9NVI7,Q9UHX1 3 +Abnormal odontoid tissue morphology 0.3155069122113726 0.3891477645263869 0.6971668416880075 1.0 0.9830394869938588 46 P16278,Q5JRA6,P34059,Q96AY3,Q9Y4P3,Q96L58,Q6P4Q7,P53701,P51648,Q15056,P48651,Q9UBM7,P21964,Q01968 14 +Akinesia 0.3797774628642362 0.388684776030439 0.6975093455433603 1.0 0.9830394869938588 11 P04062,O14656 2 +Nephrogenic diabetes insipidus 0.6393289841565643 0.3875313733576953 0.6983628633114272 1.0 0.9836368966788755 2 Q9H267 1 +Cerebral cortical atrophy 0.3082855236889963 0.3853632972181858 0.6999682712826081 1.0 0.9850662922517044 98 Q96AA3,Q9Y296,Q7LGA3,P55011,Q9UM00,P03886,Q96RL7,O00754,Q9Y4P3,P00403,Q5KU26,P05067,O96008,O76024,Q69YQ0,Q8TD16,O75648,P04062,P51812,O75503,P50148,Q9Y263,P51572,P51970,Q9Y619 25 +Type ii diabetes mellitus 0.3231246144223439 0.3795407710532203 0.7042863340954209 1.0 0.9866693395914716 38 P03886,P02545,Q9Y4P3,O76024 4 +Hyperreflexia in upper limbs 0.4042952911036109 0.3792461242861565 0.7045051030540042 1.0 0.9866693395914716 8 O75298,P21912 2 +Gastroesophageal reflux 0.3299045108300051 0.3772699693218324 0.7059729871192215 1.0 0.9866693395914716 122 Q9UHX1,O15269,P53007,Q96PU5,P07602,O43175,Q6NUK1,Q8IZA0,Q9Y4P3,O96028,Q12768,Q9UBM7,Q04656,O95202,P16435,Q01105,P51571,Q14739,Q9NZJ7,Q96A33,P12235,P21964,Q9Y619,O00203 24 +Arachnodactyly 0.3242169823938339 0.3768883801405125 0.7062565570829831 1.0 0.9866693395914716 36 Q8NCH0,O96028,Q5H8A4,P21964,O95202 5 +Microcornea 0.3266510328045661 0.376133778037559 0.706817443783367 1.0 0.9866693395914716 29 Q9NWM8,Q96J42,Q8NCH0,Q96L58,Q15555,Q15125,O43505 7 +Elevated hemoglobin a1c 0.5135089333340854 0.3760978265939301 0.7068441700363166 1.0 0.9866693395914716 4 O75431 1 +Aplasia hypoplasia affecting the eye 0.3064779721463411 0.3752910162619757 0.707444046708066 1.0 0.9866693395914716 97 Q9NVI7,Q9BXW9,P07196,Q7LGA3,Q9UHX1,O60566,Q6NUK1,O43175,Q9Y4P3,O96028,Q9UBM7,O95202,Q96J42,Q15645,Q15125,P21912,P37268,Q9NP58,P38398,P53701,P21964 21 +Abnormality of urine calcium concentration 0.3640899265551501 0.3740602603480484 0.7083594836650471 1.0 0.9866693395914716 13 P35670 1 +Narrow palate 0.3164630921256859 0.3736156286848712 0.7086903046678605 1.0 0.9866693395914716 44 P16435,Q6NUK1,P52788,P51812,Q12768,Q9Y619,P48651,Q9NZ01,P23786,Q04656 10 +Recurrent bacterial infections 0.3363241506834077 0.3735831158764555 0.708714497454564 1.0 0.9866693395914716 20 O00165,Q15904,O00203,Q8N5M9 4 +Abnormality of the upper respiratory tract 0.3043619836448007 0.3731491231352193 0.7090374596646378 1.0 0.9866693395914716 95 P34059,Q15427,P54802,Q9UHX1,P10644,O00754,P16278,P07602,Q03519,Q13510,O15460,Q9UBM7,P16435,P02545,Q15165,Q69YQ0,P36543,Q03518,Q96DX4,P28070,Q53GS7,Q14739,Q96HY6,P04637,Q04721,Q9NZJ7,P21964 27 +Difficulty climbing stairs 0.363693348257466 0.3717508911262025 0.7100783304548963 1.0 0.9866693395914716 13 P12235,P40939 2 +Adrenal insufficiency 0.3258365159532561 0.3713787040887545 0.7103554849125739 1.0 0.9866693395914716 25 P40855,Q13423,O95470,O75381 4 +Tube feeding 0.279975366040863 0.3698353598986575 0.711505166920952 1.0 0.9866693395914716 71 Q9UBB6,P07602,Q9Y289,Q01105,P37268,O14656,Q96N66,O75648,Q9NZJ7,Q15233,O75962,P55011,Q9UHX1,Q99720,Q9NZ01,Q86YH6 16 +Aplasia hypoplasia of the abdominal wall musculature 0.4284044133898202 0.3673911020847123 0.7133273077681692 1.0 0.9882982578730548 6 Q6NUK1 1 +Abnormal sacrum morphology 0.322730997929042 0.3642411820457946 0.7156779172121779 1.0 0.9912470645879649 36 Q5H8A4,Q9Y4P3,Q8TAA9,O96028,P53701,Q9UM00,Q15125,Q14739,O95202 9 +Abnormal cerebral vascular morphology 0.2752017896644396 0.3625200373092048 0.7169634527859672 1.0 0.9918355438993788 67 P38435,Q96AA3,P03886,P10644,Q9Y4P3,P00403,P06280,P05067,Q96L58,Q04656,O76024,O75844,P02545,P04062,P23786,P21912,P04637,P10253,P51970 19 +Bone spicule pigmentation of the retina 0.3866921652322316 0.3619061263751065 0.7174221816542121 1.0 0.9921703925686008 9 Q9UG56 1 +Abnormality of adrenal physiology 0.3246872632665592 0.3614002129052779 0.7178002888631556 1.0 0.9922878649363326 30 P16435,P10644,O95470,P04637,P40855,Q13423,O75381 7 +Abnormal cornea morphology 0.3564698980832061 0.3606328347914959 0.7183739402192493 1.0 0.9922878649363326 155 Q9NVI7,Q9BXW9,Q9Y296,Q7LGA3,P55011,P10619,P40855,O60566,O00754,P16278,Q6NUK1,Q9Y4P3,P06280,O96028,P39210,Q13510,P51648,Q9UBM7,P35670,O95202,O75844,P02545,Q96J42,Q9NZ08,P04062,Q15645,Q15125,Q14739,Q9NWM8,Q8NCH0,P38398,P53701,Q53H12,O75381,P12235,Q5H8A4,Q06136,P21964,Q2TAA5 39 +Acanthosis nigricans 0.380395350276314 0.3591040590480457 0.7195172451844918 1.0 0.9935673901386576 10 P02545,O75431,P31751 3 +Aplasia hypoplasia of the distal phalanges of the hand 0.3239724058324582 0.3571825154247621 0.7209551744083558 1.0 0.9937777711269452 31 O75844,P02545,Q6NUK1,P38435,P51798 5 +Albinism 0.6106374329361957 0.3548262270442713 0.7227197788450008 1.0 0.9947620436199792 3 O00203 1 +Hyperinsulinemic hypoglycemia 0.4124244553361449 0.3544489671351829 0.7230024428959816 1.0 0.9947620436199792 7 P40939 1 +Abnormality of cardiovascular system electrophysiology 0.3205775502365848 0.3527338099789728 0.7242880098337681 1.0 0.9947620436199792 114 P04899,O43819,P40855,P03886,P40939,Q16836,P07602,O43572,P42892,P50402,Q9Y4P3,P06280,Q99643,P00403,O14656,P50416,O15460,P02545,Q69YQ0,Q8TB36,P04062,Q8WXH0,O75208,P23786,P21912,P50148,P12235,P04637,Q9NZJ7,P10253,O75880,P53701,P51970,P13473,O75306,O75381 36 +Seborrheic dermatitis 0.3791222859541127 0.3524949015877169 0.7244671413711332 1.0 0.9947620436199792 10 P21964 1 +Abnormal meningeal morphology 0.322737061418613 0.3520178829919154 0.7248248510952928 1.0 0.9947620436199792 23 P21964,Q9UHX1,Q10713 3 +Abnormal systemic arterial morphology 0.3433627153190988 0.3515846717682334 0.7251497623214358 1.0 0.9947620436199792 140 P38435,Q9BXW9,Q9Y296,Q7LGA3,Q9UHX1,P55011,P06865,P10619,P03886,O60566,Q96PU5,P16278,P10644,P07602,Q6NUK1,P17900,Q9Y4P3,Q96L58,P05067,Q13510,O15460,Q9UBM7,O15118,Q04656,O75844,P02545,Q69YQ0,P04062,P61916,Q15645,P21912,Q9NWM8,Q9NZJ7,P10253,P38398,P53701,P21964 37 +Recurrent urinary tract infections 0.3230206975224511 0.3515686755190225 0.7251617605598364 1.0 0.9947620436199792 32 P20700,Q9BXW9,Q9Y4P3,P38398,Q13423,Q04656,O76024 7 +Dry skin 0.3225575026091299 0.3505001288856293 0.7259633934398564 1.0 0.9955634556936516 33 P37268,Q06136,P51648 3 +Myoglobinuria 0.3781823223196291 0.3476285253211454 0.7281191807552672 1.0 0.9968267399736276 10 P40939,Q16836 2 +Abnormality of the auditory canal 0.3325111387673884 0.3467432650927451 0.7287842034988172 1.0 0.9968267399736276 20 O96028,Q9Y619,O95202 3 +Glomerular sclerosis 0.321640482855168 0.3462605070160466 0.7291469457434132 1.0 0.9968267399736276 34 Q14108,P00403,Q8NFH4,P03886,O95470,O75431,P21912 7 +Abnormality of the choanae 0.3189792749272745 0.343637345494079 0.7311190355420649 1.0 0.9968267399736276 38 P16435,O75844,P02545,Q9BXW9,P38398,P48651,Q9UBM7,P21964 8 +Bulbous nose 0.315418033593261 0.3434944060685471 0.731226548441374 1.0 0.9968267399736276 42 P16435,P42892,Q96A33,O75431,P21964 5 +Hypoplasia of the odontoid process 0.4225671053107855 0.3431892894656165 0.7314560617092574 1.0 0.9968267399736276 6 P16278,O95831 2 +Eeg with polyspike wave complexes 0.4225147525578273 0.3429740136535298 0.7316180098538252 1.0 0.9968267399736276 6 Q14108 1 +Arrhinencephaly 0.3650109901429791 0.3428954258863735 0.7316771330057534 1.0 0.9968267399736276 12 P21964,Q8TAA9 2 +Inguinal hernia 0.2858500911802882 0.3415892611117799 0.7326600199897229 1.0 0.9968267399736276 79 P34059,Q9UHX1,Q10713,Q9UM00,O00754,P16278,O43175,Q9Y4P3,O14656,Q12768,P48651,Q04656,Q01968,Q69YQ0,P36543,P51812,Q15555,Q15056,Q9NWM8,Q8NCH0,Q04721,Q96S52,Q9Y487,P51970,Q32P28,P21964 26 +Gliosis 0.3179120395178644 0.3410793080768968 0.7330438780017547 1.0 0.9968267399736276 39 Q13144,O00754,Q9H9P8,P20700,Q16134,Q7KZN9,P04062,O43819,Q10713 9 +Abnormality of pelvic girdle bone morphology 0.3488821017655524 0.3383217546385446 0.7351207314702466 1.0 0.998109215589966 148 Q9NVI7,P34059,Q9BXW9,Q9NQT5,Q9Y296,Q7LGA3,Q9UHX1,P55011,P53007,O00754,P16278,Q8IZA0,Q9Y4P3,Q96L58,O96028,O14656,Q03252,Q12768,P51798,Q9UBM7,Q04656,O95202,O75844,P16435,P02545,O95831,P57678,Q8TD16,O75648,Q8TAA9,P51812,Q15125,O75431,Q14739,Q96HY6,Q96AY3,P38398,Q96A33,Q969X5,Q9Y487,O15228,Q5H8A4,Q9Y619,O00203 44 +Mutism 0.3511058795776008 0.3372261804135097 0.7359464028819351 1.0 0.998109215589966 14 Q13510 1 +Hemoptysis 0.5013597432677972 0.3367430450402778 0.7363106112757705 1.0 0.998109215589966 4 Q9NZ08,P49327 2 +Delayed ability to stand 0.5006860892671869 0.3346054336802121 0.7379227454893775 1.0 0.998109215589966 4 P10253,P21912 2 +Preauricular skin tag 0.3390995804666949 0.3340222779613901 0.7383627478128592 1.0 0.998109215589966 17 Q12768,O95202 2 +Hypoplasia of the frontal lobes 0.3752240628951473 0.3323895744208203 0.7395951098813232 1.0 0.998109215589966 10 O14578,Q9UBM7,Q86XL3 3 +Abnormality of dental morphology 0.2759837436297236 0.3320287805773595 0.7398675268588857 1.0 0.998109215589966 63 Q6NUK1,Q9Y296,Q9Y4P3,Q96L58,P38398,Q7LGA3,P51812,P55011,Q9Y487,Q96A33,Q9UM00,P51798,Q9UBM7,Q9Y619,Q12959 15 +Abnormal morphology of the musculature of the neck 0.3427784403631559 0.3287848919886417 0.7423182832547237 1.0 1.0 15 Q99720,O14656,Q96L58 3 +Primary peritoneal carcinoma 0.4189214642690982 0.3282764586641107 0.7427026420659184 1.0 1.0 6 P04637 1 +Muscular dystrophy 0.3199889013132158 0.3263445107207615 0.7441637152492797 1.0 1.0 25 P02545,O43175,P50402,O14979,Q8WXH0,Q15645,O60566 7 +Vasculitis 0.3929766830370718 0.3261326279224389 0.744324011893869 1.0 1.0 8 Q9NZ08,Q9UBC1,P49327,O15460 4 +Abnormality of facial soft tissue 0.322817644430753 0.3255914986576683 0.7447334451008767 1.0 1.0 119 O60313,P07196,P51530,O75787,Q9UHX1,O43819,P53007,P40855,O00754,Q9Y4P3,Q03252,Q13510,Q12768,P48651,P51798,Q9UBM7,O75844,P16435,P02545,Q9BQT8,Q15043,P04062,P51812,Q8NFH4,P21912,Q9Y263,P10253,P12235,O75381 29 +Central hypoventilation 0.4055160974791993 0.3242628244325213 0.7457390621911864 1.0 1.0 7 O43819 1 +Nail dysplasia 0.3200473111877979 0.3235882934384519 0.7462497519970199 1.0 1.0 29 P42892,P10321,O96028,Q9Y619,P48651,P16615,O95202 7 +Dysmetria 0.2936320333955572 0.3232919426958171 0.7464741554549634 1.0 1.0 55 O60313,Q9Y4W6,Q9NW15,O75787,O14773,Q10713,Q96TA2,Q5T8D3,Q5JRX3,Q9Y4P3,Q12768,Q6P4A7,P20700,O75503,Q15056,Q8N2K0,Q9UBB4,Q9UNE7,O75027,Q8IV08 20 +Narrow vertebral interpedicular distance 0.5984829797216358 0.3213882117871326 0.7479162153098555 1.0 1.0 3 P10644 1 +Vertebral arch anomaly 0.5984829797216358 0.3213882117871326 0.7479162153098555 1.0 1.0 3 P10644 1 +Abnormal shape of the frontal region 0.3076715567258525 0.3213288496360747 0.7479611958443904 1.0 1.0 103 Q9NVI7,P20674,Q9BXW9,Q15392,O60566,O00754,P16278,Q96L58,O96028,Q12768,P48651,P51798,O95202,P16435,P13073,P51812,Q15645,Q15125,O75431,Q14739,P38398,Q9Y487,Q5H8A4,O75962,Q9Y619 25 +Hepatocellular carcinoma 0.3286853228429681 0.3200346493177458 0.7489420644007101 1.0 1.0 20 P35670,Q9UJS0 2 +Hereditary nonpolyposis colorectal carcinoma 0.4042191113653793 0.3186621906319831 0.7499826885354495 1.0 1.0 7 P04637 1 +Pharyngitis 0.5970002464957946 0.3174072903822025 0.7509345760839126 1.0 1.0 3 O15460 1 +Biparietal narrowing 0.4161627586507016 0.3170993230427755 0.7511682385333205 1.0 1.0 6 Q10713 1 +Micropenis 0.2843860402203165 0.3159829423602753 0.7520154553589835 1.0 1.0 59 P16435,Q9NVI7,Q6NUK1,Q9BXW9,P42892,Q03252,P53701,Q10713,O95470,P46977,Q9UBM7,Q9Y619 12 +Contractures involving the joints of the feet 0.3246196479050783 0.3137196917769078 0.7537339434205639 1.0 1.0 21 O60313,P02545,P50402,Q8IZA0,Q8TD16,O94905,Q8WXH0 7 +Keratoconjunctivitis 0.371401019430857 0.3128741144527558 0.7543763046214302 1.0 1.0 10 Q14739 1 +Retinal dystrophy 0.2998283871267498 0.311627093380743 0.7553239413326143 1.0 1.0 51 P38435,Q9NQT5,Q6P4Q7,P53701,P56589,Q10713,Q15555,P40855,P03886,Q8N2K0,O75381,O43505,Q5T8D3,P22570 14 +Abnormal lactate dehydrogenase level 0.337091478612709 0.3064732000243426 0.7592443820300316 1.0 1.0 16 Q5JRX3,Q9UJS0,P04637,P10253,P23786,O43505,Q96RL7 7 +Recurrent respiratory infections 0.3247493400675134 0.3062489499476603 0.7594151049573343 1.0 1.0 123 P54802,P53007,P16278,Q03519,P07602,P09601,Q9Y4P3,O96028,Q13510,Q12768,O15460,P51798,O95202,P20700,Q03518,P04062,Q8N5M9,Q9NZJ7,P10253,Q9Y487,Q5H8A4,O00203 22 +Capillary malformation 0.3390271037060962 0.305782126616523 0.759770537957311 1.0 1.0 15 Q9UHX1 1 +Multifocal epileptiform discharges 0.3176542211979614 0.3055109031111845 0.7599770671915334 1.0 1.0 27 Q9UBX3,Q96N66,O75503,P55011,Q9NZ01 5 +Hallux valgus 0.3365793002194924 0.3032722932735087 0.7616823592654243 1.0 1.0 16 Q15427,Q9Y4P3,Q96L58,Q15233,P04062 5 +Hamartomatous polyposis 0.4898009283666532 0.3007481511938799 0.7636065482138801 1.0 1.0 4 Q99643,P21912 2 +Abnormal caudate nucleus morphology 0.3740844520941946 0.2995738616979101 0.7645022243026824 1.0 1.0 9 O43819 1 +Pain 0.3685789390641251 0.2960855546145736 0.7671647454133819 1.0 1.0 178 O60313,Q5HYI8,O15269,Q15800,P40939,P10644,P07602,P50402,P42892,Q9Y4P3,P06280,Q03252,Q13510,Q13423,O15460,P51798,P35670,Q04656,O75844,P02545,Q15165,P20700,Q9NR77,Q9NZ08,Q70HW3,Q15043,P04062,Q8NFH4,Q15645,Q14108,P23786,P21912,Q14739,Q9H6K4,Q96HY6,O95140,P04637,Q9NZJ7,P38398,P12235,P21964 41 +Moderate global developmental delay 0.3730961903480633 0.2947815350586765 0.7681607728780844 1.0 1.0 9 O95831,O43175 2 +Headache 0.2674454278728594 0.2937153876389148 0.7689753950501697 1.0 1.0 65 O60313,P10644,P12235,Q9NZ08,P04637,P00403,P05067,P04062,Q8NFH4,O15460,P03886,P23786 12 +Spina bifida 0.3147921690319558 0.293165362416791 0.7693957582691189 1.0 1.0 35 Q9HC21,O43175,Q9BXW9,Q9Y4P3,P38398,Q9UHX1,Q10713,P21964 8 +Long neck 0.5873063865271404 0.291925860952734 0.7703433101149384 1.0 1.0 3 Q15125 1 +Large for gestational age 0.3724607768512074 0.2917078816612675 0.7705099825079709 1.0 1.0 9 Q9UM00,P31751,Q9UKG1 3 +Abnormal shoulder morphology 0.3156993576785991 0.2906507675138083 0.7713184285004786 1.0 1.0 31 Q96PU5,P02545,Q9Y4P3,Q7LGA3,Q9Y619,Q04656 6 +Rotary nystagmus 0.4860705215682839 0.2894504958374416 0.7722366577761177 1.0 1.0 4 O94905 1 +Anorectal anomaly 0.2731788882004006 0.2875792268657465 0.7736688479979659 1.0 1.0 71 P16435,Q6NUK1,Q9BXW9,Q69YQ0,P04637,Q9Y4P3,Q99643,P38398,P51812,P53701,Q12768,P48651,P21964,P21912,P16615 15 +Thyroiditis 0.3843759726112613 0.2868889342386748 0.7741973637053283 1.0 1.0 8 Q96J02,P42224,Q15437,P50851,Q13043,P49327,P54098 7 +Highly arched eyebrow 0.2746146784484864 0.2863920518165326 0.7745778616116068 1.0 1.0 62 Q5H8A4,O00754,Q69YQ0,Q9Y296,O75648,O96028,Q5KU26,Q7LGA3,P51812,Q9UHX1,P55011,Q10713,Q9UM00,O75962,O95202 15 +Aspiration 0.3658450041460746 0.2848910110473245 0.7757276428911013 1.0 1.0 10 P06865,P17900 2 +Brain imaging abnormality 0.3118787629789023 0.2828066825129323 0.7773250314650033 1.0 1.0 38 P07602,Q9BT22,Q9NZJ7,O43819,P03886 5 +Orofacial dyskinesia 0.4071303570247244 0.2811852677365227 0.7785683036569824 1.0 1.0 6 Q96RL7 1 +Aplasia hypoplasia of fingers 0.2935005314900138 0.2786981590143124 0.7804764754522973 1.0 1.0 92 O75844,P16435,P02545,Q6NUK1,O95831,P38435,P13073,Q03252,O96028,P38398,P51812,Q13510,Q9UHX1,O75962,Q5H8A4,P51798,Q9UBM7,O95202 18 +Sleep apnea 0.3159772599614366 0.2754259211714001 0.7829890316864843 1.0 1.0 22 Q96A33,P51812,P51530,P53007 4 +Impaired smooth pursuit 0.3339167391679295 0.2748277298727337 0.7834485927612851 1.0 1.0 15 Q9UBB4,P46977,Q10713 3 +Diabetes insipidus 0.3334600130495348 0.2720838169470316 0.7855575725199284 1.0 1.0 15 P06280,O76024 2 +Abnormality of the tonsils 0.3573654704088053 0.2697452321855307 0.7873562596741426 1.0 1.0 11 P31751,P21964 2 +Anophthalmia 0.3922801336780547 0.2681681526872235 0.7885698879134575 1.0 1.0 7 P53701,O43505,Q96J42 3 +Congenital diaphragmatic hernia 0.3114725847330251 0.2675555578311672 0.7890414437147646 1.0 1.0 23 O96028,Q5H8A4,P53701,O95202 4 +Nail dystrophy 0.3123729177192025 0.2664724989621169 0.789875336600045 1.0 1.0 26 O75844,P02545 2 +Focal non motor seizure 0.3614736042428433 0.2632088728705694 0.7923895923001958 1.0 1.0 10 O43175 1 +Abnormality of the fontanelles or cranial sutures 0.3099234432768754 0.2600746497284714 0.7948061918377622 1.0 1.0 111 P20674,Q9BT22,Q9NX62,P40855,Q9UM00,O00754,Q6NUK1,Q96L58,Q12768,P48651,P51798,Q04656,O75844,P16435,P02545,O95831,Q16134,Q69YQ0,P51812,Q15125,O75431,Q96AY3,Q8NCH0,Q9Y487,Q9Y619,O75381,P21964 27 +Nonketotic hypoglycemia 0.4144697036051156 0.2583625589117279 0.7961271095274287 1.0 1.0 5 P23786 1 +Aplasia hypoplasia of the uterus 0.3271700792904132 0.2579161835576027 0.7964715946387746 1.0 1.0 17 O96028,O95202 2 +Abnormality of chromosome stability 0.3430758035821803 0.2548680814767155 0.7988249896029602 1.0 1.0 13 P38398,P13073,P33991 3 +Abnormality of the supraorbital ridges 0.3161430241328472 0.2540188946222989 0.799480960959839 1.0 1.0 21 P40855,P16435,Q6NUK1,O75381 4 +Abnormality of the optic nerve 0.4088893816063448 0.2530930091728699 0.8001963409282111 1.0 1.0 247 Q9P0J0,O60313,Q9NVI7,Q9H9P8,Q9HC21,P38435,O43681,P07196,Q9H061,Q7KZN9,Q9Y296,Q7LGA3,Q9UHX1,O43819,Q10713,P40855,P03886,O43676,Q96PU5,P16278,P50897,P07602,P10644,Q96CU9,P06280,P00403,O96028,Q5KU26,O14656,Q12768,Q86Y39,O15460,P51798,Q9UBM7,O95202,O76024,O95831,Q96J42,Q9NZ08,P57678,Q15043,O95299,P04062,O96000,Q6P4Q7,P51812,Q9Y6M9,Q15125,Q9BPX6,Q9H6K4,Q13144,Q9UG56,Q8WWV3,Q5XKP0,Q9Y263,P37268,P51572,P04637,Q9NZJ7,Q96S66,Q5H8A4,O75381,P21964 63 +Nasal speech 0.3094904769609639 0.2495608083280797 0.802927010103347 1.0 1.0 35 P52788,Q9Y296,O75648,Q15233,Q7LGA3,P55011,Q9Y487,P53007,P21964,Q12959 10 +Overlapping toe 0.3089960682205277 0.2492986626225699 0.8031297657464211 1.0 1.0 23 Q15427,Q96A33,Q9UHX1,Q9UM00,Q15125,Q9UBM7 6 +Increased total bilirubin 0.4720648767389986 0.2485041836039342 0.80374433353678 1.0 1.0 4 P23786 1 +Abnormal coronary artery morphology 0.3982322087625188 0.2468925921825167 0.8049913494793972 1.0 1.0 6 P02545 1 +Brachycephaly 0.2645788638445518 0.2465812969955862 0.8052322805069458 1.0 1.0 66 P16435,P10644,O00754,Q6NUK1,Q69YQ0,Q8NCH0,P52788,P04062,Q96A33,Q12768,Q9UM00,O75431,O60566,Q04656 14 +Temporal cortical atrophy 0.5690213927987275 0.246541830355453 0.8052628275565943 1.0 1.0 3 Q9UQN3 1 +Abnormal neuron morphology 0.3100008033429074 0.2457081648242106 0.8059081513158384 1.0 1.0 28 Q92804,Q15165,Q16637,Q8IY17,O94905,Q13510,Q53GS7,Q99720 8 +Abnormality of the pancreas 0.2726952590859446 0.2449538590468067 0.8064921582162246 1.0 1.0 74 P02545,P09601,Q96J42,Q9UJS0,Q9NZ08,P04637,Q15904,P00403,Q5HYI8,Q9UHX1,P03886,Q14739 12 +Decreased specific anti polysaccharide antibody level 0.567824914624103 0.2436987436032693 0.8074641464984786 1.0 1.0 3 P49327 1 +High forehead 0.2951349872589632 0.2410920435256192 0.8094837792743816 1.0 1.0 97 Q04656,Q9NVI7,Q15645,Q9NX62,Q15904,Q9Y4P3,O96028,Q7LGA3,O75962,Q12768,P23786,P40855,Q5H8A4,O75431,O75381,Q14739,O95202 17 +Sparse or absent eyelashes 0.3082938306745665 0.240850468474409 0.8096710125434856 1.0 1.0 24 O75844,P02545,O43175 3 +Abnormal nasolacrimal system morphology 0.3454830508217406 0.2374389777069719 0.8123162542983364 1.0 1.0 12 P53701,Q6NUK1,O43175 3 +Decreased circulating level of specific antibody 0.3842563783447403 0.2353869258772608 0.8139084326720769 1.0 1.0 7 Q9H0U3,Q9Y2V7,Q13546,P50851,P17812,P49327 6 +Skin nodule 0.3102020494427284 0.2340846204574631 0.8149192853726643 1.0 1.0 22 Q9NZ08,P06280,Q13510,P21912,P16615 5 +Expressive language delay 0.3448354083645286 0.2340515337709892 0.8149449713623564 1.0 1.0 12 Q13509,Q96DX4,Q9UHX1,Q8NB90,P21912 5 +Hamartoma of tongue 0.5787511649580508 0.2335645441749707 0.8153230560825158 1.0 1.0 2 P08754 1 +Tall stature 0.2810391099090495 0.2330932618510258 0.8156889870779092 1.0 1.0 57 P16435,P10644,O00754,Q9NWM8,Q8NCH0,P52788,Q9Y296,P51530,O96028,O75648,Q7LGA3,Q15233,P55011,Q13423,Q5H8A4,O95202 16 +Neoplasm of the breast 0.3083054920192448 0.2318690018611594 0.8166397613733762 1.0 1.0 30 P10644,P02545,P35232,P04637,Q5HYI8,P38398,O75330,P21912 8 +Mesomelia 0.3937068812307006 0.2298941046817335 0.8181740574343224 1.0 1.0 6 Q14739 1 +Lipoma 0.3713358342896667 0.2294698026661485 0.818503788458186 1.0 1.0 8 Q99643,Q15437,P21912,Q8TAA9 4 +Abnormality of the extraocular muscles 0.4650295306185993 0.2288511113641233 0.8189846396350797 1.0 1.0 4 Q9BVA1,Q13509,P43243 3 +Neoplasm of the respiratory system 0.3322295100047605 0.2277819890982772 0.8198157292735053 1.0 1.0 14 Q15645,P02545 2 +Dicarboxylic aciduria 0.3055328520033777 0.2205505112923785 0.8254424383541359 1.0 1.0 24 Q9H9P8,O75880,P40939,P23786,Q16836 5 +Early onset of sexual maturation 0.3014196320511701 0.2195054167474492 0.826256360799499 1.0 1.0 42 P02545,Q5JRA6,Q9Y4P3,Q9Y296,O96028,Q7LGA3,Q13423,O95202 8 +Abnormal lymphocyte morphology 0.3062970575186058 0.2188590202864345 0.8267598696251475 1.0 1.0 33 P16278,O00203,Q03252,O75787,O95470,P33991 6 +Neoplasm of fatty tissue 0.3465631766324984 0.2152295749073127 0.8295883337697925 1.0 1.0 11 Q9ULK5,O95140,Q8TAA9,Q99643,Q15437,P21912 6 +Focal dystonia 0.3039666349778284 0.2126176898073003 0.8316251724453771 1.0 1.0 23 O14656,Q15043,Q96L58,Q99720,Q96RL7 5 +Localized osteoporosis 0.5684995340167638 0.2119546291528307 0.8321424307614562 1.0 1.0 2 P57740 1 +Pituitary growth hormone cell adenoma 0.553900515214619 0.2117968109112627 0.8322655566094854 1.0 1.0 3 P10644 1 +Skin vesicle 0.3458625791200616 0.2117667766410137 0.8322889890627825 1.0 1.0 11 P16615 1 +Aplasia hypoplasia affecting the fundus 0.3047180793657753 0.2116002334505171 0.8324189271872171 1.0 1.0 25 P37268,Q9NVI7,Q9UHX1 3 +Limb joint contracture 0.2982570846785886 0.2110756538024544 0.8328282376904901 1.0 1.0 103 O60313,Q9HC21,P07196,Q15392,Q13509,Q86XL3,Q7LGA3,Q99567,O43175,O75477,P50402,P42892,Q8IZA0,O14656,Q96L58,P48651,Q01968,O75844,P16435,P02545,Q9NR77,Q8TD16,Q8WXH0,Q99720,Q8N2K0,P23786,P21912,Q96AY3,P37268,O94905,Q969X5,Q9Y619 32 +Abnormality of the small intestine 0.2910787556552324 0.2110688669289295 0.832833533539354 1.0 1.0 50 Q9BXW9,Q9BT22,Q8NCH0,O96028,P38398,P51812,Q96A33,Q14566,Q15645,Q14739,O95202 11 +Profound hearing impairment 0.3999903542724278 0.2095281891927679 0.8340359319352915 1.0 1.0 5 Q9NR77 1 +Long palm 0.5527767070100702 0.2093187369125162 0.8341994258035057 1.0 1.0 3 P16435 1 +Abnormality of the foot musculature 0.4573078331273849 0.2080183498748054 0.835214639613892 1.0 1.0 4 O14979,P50570 2 +Abnormality of the dorsal column of the spinal cord 0.5517277588014069 0.2070189417791483 0.8359950655267183 1.0 1.0 3 Q8WVX9 1 +Open mouth 0.3045184557971099 0.2056051649725227 0.8370993426629687 1.0 1.0 27 P10644,Q86XL3,Q15233,P04062,P51812,Q10713 6 +Dysdiadochokinesis 0.3221572715231413 0.2054690392653288 0.8372056851263405 1.0 1.0 15 O75503,P20700 2 +Craniosynostosis 0.2956512033800984 0.2046238068760138 0.8378660537550968 1.0 1.0 46 P16435,O00754,Q6NUK1,Q9NX62,Q8NCH0,Q96L58,Q9Y619,Q9UM00,P51798,P21964 10 +Bone marrow foam cells 0.5501563120381778 0.2035975130110523 0.8386680367685087 1.0 1.0 3 O15118 1 +Agenesis of permanent teeth 0.5635290462876557 0.2019658279925003 0.8399434389592844 1.0 1.0 2 Q14696 1 +Abnormality of the plantar skin of foot 0.3019655338886408 0.1995861408669336 0.8418042676890747 1.0 1.0 38 Q06136,P02545,Q9Y487,P42167 4 +Recurrent sinusitis 0.3967661691542205 0.1990758350583676 0.8422034237163321 1.0 1.0 5 Q9H0U3,Q86Y56,O14920,Q15833 4 +Non midline cleft lip 0.396358516281771 0.1977656513557111 0.8432284215933608 1.0 1.0 5 Q96L58 1 +Absent forearm bone 0.395976482200397 0.1965401413010964 0.8441874170740793 1.0 1.0 5 O75962,Q9BXW9 2 +Nonimmune hydrops fetalis 0.303310320731552 0.1950288189551551 0.8453703865328426 1.0 1.0 28 P04062,Q9BT22,P10619 3 +Generalized hypopigmentation of hair 0.3626217251694612 0.1926518988955119 0.8472315967591733 1.0 1.0 8 P10644,O00203,Q05086 3 +Recurrent mycobacterial infections 0.558247903075477 0.191704851067483 0.8479734058678634 1.0 1.0 2 Q86Y56 1 +Delayed ability to walk 0.2613642748008041 0.1904684730522475 0.8489420458027457 1.0 1.0 64 P49366,Q5H8A4,P20700,Q01105,O75648,Q03252,Q96N66,O94905,Q15233,P55011,Q10713,P53007,Q99720,Q3ZCQ8,O75962,P21912 16 +Abnormality of the nasal tip 0.2888014385845016 0.1897041849015271 0.8495409412853088 1.0 1.0 95 O75844,P16435,P02545,P16278,P10644,O95831,P42892,P35573,Q96A33,Q7LGA3,P51812,Q9UHX1,Q9Y487,O75431,P23786,P21964 16 +Restlessness 0.3005476934115204 0.1878726322281742 0.8509764970166378 1.0 1.0 38 P10644,Q15165,Q9UJS0,P42892,P04062,P05067 6 +Tapered finger 0.3017236414220028 0.1845096496624949 0.8536136577814684 1.0 1.0 34 P42892,Q8NCH0,Q03252,Q06136,O75962,P23786 6 +Hypoventilation 0.3299854745790915 0.1845026164587357 0.8536191747565607 1.0 1.0 13 Q13724,P11047,O43819,O75306,P61978,O75380 6 +Sleep wake cycle disturbance 0.3918052709100917 0.1833079887494474 0.85455636648917 1.0 1.0 5 Q9UBM7 1 +Abnormal platelet aggregation 0.447493974838515 0.1826944068000236 0.8550378046270801 1.0 1.0 4 O00203 1 +High narrow palate 0.3016482452487524 0.1822579560193698 0.8553802922333984 1.0 1.0 33 P16435,Q6NUK1,Q12768,Q9Y619,P48651,P23786,Q04656 7 +Impaired antigen specific response 0.3597883597883595 0.1809704824307462 0.856390745044199 1.0 1.0 8 Q9H0U3,P00813,Q9Y2V7,Q13546,P50851,P17812,P49327 7 +Abnormality of fibula morphology 0.3292923657371002 0.1808740991215789 0.8564663994179775 1.0 1.0 13 P16435,O75431,Q96HY6,Q04656 4 +Bronchitis 0.3798090745233369 0.1796924991363996 0.8573939824155894 1.0 1.0 6 Q03519 1 +Keratitis 0.339236544880533 0.1794883927058374 0.8575542306147068 1.0 1.0 11 Q14739 1 +Acute lymphoblastic leukemia 0.3160561857222599 0.1791000526001676 0.8578591407054825 1.0 1.0 16 Q15645,O00165,P04637 3 +Limb tremor 0.3793611177117466 0.1781270616171781 0.8586231897814731 1.0 1.0 6 P20700 1 +Porphyrinuria 0.5351149782473722 0.1723191003233228 0.8631866690686358 1.0 1.0 3 P50336,P36551 2 +Respiratory paralysis 0.5351149782473722 0.1723191003233228 0.8631866690686358 1.0 1.0 3 P50336,P36551 2 +Elevated urinary dicarboxylic acid level 0.5351149782473722 0.1723191003233228 0.8631866690686358 1.0 1.0 3 P50336,P36551 2 +High anterior hairline 0.3013679435085116 0.1722505384897154 0.8632405676218848 1.0 1.0 22 O96028,Q5H8A4,Q7LGA3,O95202 4 +Scarring 0.3002926710039816 0.171687287903279 0.8636833801978567 1.0 1.0 33 Q9NWM8,P53634,P04439,Q8NCH0,Q92542,Q96L58,Q15125,Q04656,Q01968 9 +Mandibular prognathia 0.2985712932875048 0.171632071460917 0.8637267921979279 1.0 1.0 38 P10644,O00754,Q9NVI7,P34059,P16278,Q6NUK1,Q05086,P52788,P51812,P55011,Q9UHX1,P48651,Q01968 13 +Shoulder girdle muscle atrophy 0.5335612181479317 0.1692414659069205 0.8656067151138116 1.0 1.0 3 Q9Y223,P06753 2 +Abnormality of the bladder 0.3146220609829713 0.1689137646517474 0.8658644721468909 1.0 1.0 125 O43681,Q9UHX1,P07602,Q9Y4P3,Q12768,Q04656,O76024,P16435,P20700,Q9NR77,P04062,O75298,Q99720,Q9UBB4,Q9NWM8,Q9UJS0,Q8NCH0,Q9NZJ7,P12235,O75962,P21964 21 +Abnormal circulating androgen level 0.3314430932142225 0.1658356839837693 0.868286263167177 1.0 1.0 12 P16435,Q13423 2 +Prominent nasal bridge 0.2875547096823462 0.1646503613559836 0.8692191894981129 1.0 1.0 49 P49366,Q5JRA6,P20700,Q69YQ0,P42892,P13073,P52788,Q15233,P38398,Q10713,Q15125,P21964 12 +Hepatocellular adenoma 0.5301799882809786 0.1626443289522749 0.8707984822164412 1.0 1.0 3 P10644 1 +Abnormal facial expression 0.2977410943059103 0.1577500604788793 0.874653751761514 1.0 1.0 36 Q9Y263,Q9NR77,P51530,Q15043,P04062,O75787,Q969X5,Q53GS7,P12235,Q04656 10 +Adenoma sebaceum 0.382888694714429 0.1559582943056367 0.8760658952049591 1.0 1.0 5 Q99643,Q15437,P21912 3 +Angiofibromas 0.382888694714429 0.1559582943056367 0.8760658952049591 1.0 1.0 5 Q99643,Q15437,P21912 3 +Sparse eyelashes 0.3084089928714744 0.1547638382402846 0.8770075005610256 1.0 1.0 18 O75844,P02545 2 +Bilateral single transverse palmar creases 0.3188332137045764 0.1543100572036105 0.8773652677942803 1.0 1.0 14 P40855 1 +Primary gonadal insufficiency 0.3421953124056331 0.1531407892400696 0.8782872500690895 1.0 1.0 9 Q13144,P51809,O76024 3 +Steroid resistant nephrotic syndrome 0.3818407960198916 0.1528299852563605 0.8785323506878557 1.0 1.0 5 Q9BW27,Q8WUM0,Q92621,Q8N1F7 4 +Spastic dysarthria 0.3419749766267497 0.1521948550099356 0.8790332518007402 1.0 1.0 9 Q8WVX9,Q9Y4W6,O94905 3 +Dark urine 0.5349487418452796 0.1507824424288452 0.8801473368154638 1.0 1.0 2 P36551 1 +Late onset 0.3375631854593082 0.1505938510862382 0.880296112195625 1.0 1.0 10 P18031,Q9Y6M1,P31751,O76024 4 +Skeletal muscle atrophy 0.3451327707757046 0.1489412706041199 0.8815999751606101 1.0 1.0 164 O60313,O00400,Q9NVI7,Q9HC21,P07196,Q9NQT5,P51530,O15269,O43819,P53007,Q6UWE0,Q96RL7,P10644,P16278,O43175,P50402,Q03252,P39210,Q13510,Q12768,Q6P4A7,P50416,Q04656,P02545,Q15165,O95831,Q9NR77,Q8TB36,Q9BQT8,P35573,Q8TD16,P46020,Q8WXH0,P51812,O75298,Q99720,P21912,Q9NWM8,P12235,O95140,O14979,O94905,P51970,P13473,Q13126 45 +Exertional dyspnea 0.3006591648243716 0.1488517734404554 0.8816705963684535 1.0 1.0 21 O75844,P10644,P02545,P12235 4 +Reduced vital capacity 0.5333954644299341 0.1483056432969751 0.88210156190456 1.0 1.0 2 P06753 1 +Eeg with continuous slow activity 0.5333954644299329 0.1483056432969731 0.8821015619045616 1.0 1.0 2 Q9UQN3 1 +Lack of insight 0.5333954644299329 0.1483056432969731 0.8821015619045616 1.0 1.0 2 Q9UQN3 1 +Grammar specific speech disorder 0.5333954644299329 0.1483056432969731 0.8821015619045616 1.0 1.0 2 Q9UQN3 1 +Collectionism 0.5333954644299329 0.1483056432969731 0.8821015619045616 1.0 1.0 2 Q9UQN3 1 +Expressive aphasia 0.5333954644299329 0.1483056432969731 0.8821015619045616 1.0 1.0 2 Q9UQN3 1 +Senile plaques 0.5333954644299329 0.1483056432969731 0.8821015619045616 1.0 1.0 2 Q9UQN3 1 +Elevated tissue non specific alkaline phosphatase 0.533395464429933 0.1483056432969731 0.8821015619045616 1.0 1.0 2 Q13043 1 +Alexia 0.5333954644299329 0.1483056432969731 0.8821015619045616 1.0 1.0 2 Q9UQN3 1 +Cerebral hypoplasia 0.3120215382434397 0.1480845270652741 0.8822760604231739 1.0 1.0 15 O14578,O43175,Q86XL3,Q9UBM7,O60566,P22570 6 +Telecanthus 0.2913413845448185 0.1477131073705669 0.882569186932264 1.0 1.0 44 O75844,P02545,Q8NCH0,P21964 4 +Sclerosis of skull base 0.5220773791472523 0.1473972559822182 0.8828184712766831 1.0 1.0 3 Q14739 1 +Abnormality of thyroid physiology 0.2683859228492267 0.1467448657703327 0.8833334041499126 1.0 1.0 78 O60313,P12235,Q15645,Q9Y4P3,P00403,Q13423,P03886,O95470,P21964,O76024 10 +Velopharyngeal insufficiency 0.4324640944709242 0.1465138766681503 0.8835157361299517 1.0 1.0 4 Q12959 1 +Down sloping shoulders 0.2955538567677769 0.1452180298981439 0.8845387310268964 1.0 1.0 25 P02545,Q9Y4P3,Q9Y296,Q7LGA3,P55011,Q04656 6 +Inflammation of the large intestine 0.32231920199502 0.1449617602446935 0.8847410637183004 1.0 1.0 13 Q9Y2V7,P01889,P49748,P08183,P42224,Q6PGP7,Q13546,P09884,Q15833,P50851,Q13043,P49327 12 +Neoplasm of the thyroid gland 0.2948130599728678 0.139947642679048 0.8887013582413568 1.0 1.0 25 P10644,P02545,P42892,P04637,P21912,Q04656 6 +Abnormal stomach morphology 0.2697764272147465 0.1396734262253661 0.8889180233585918 1.0 1.0 80 Q04656,Q96PU5,P10644,P21912,P04637,Q8NCH0,Q9Y4P3,Q99643,P04062,P51812,P40855,Q15645,Q9UBM7,O75381,O60566,Q14739,O76024 17 +Abnormality of the abdominal wall 0.3057377147894335 0.1387452743998787 0.8896514402705269 1.0 1.0 118 P34059,Q15427,Q9BXW9,Q9UHX1,Q10713,Q9UM00,O00754,P16278,Q6NUK1,O43175,Q9Y4P3,O14656,Q12768,P48651,Q9UBM7,Q04656,Q01968,O75844,P02545,Q69YQ0,P36543,P51812,Q15555,Q15056,Q14739,Q9NWM8,Q96HY6,Q8NCH0,Q04721,Q96S52,P38398,Q9Y487,P51970,Q32P28,P21964 35 +Prostate neoplasm 0.358633521699788 0.1378312189943524 0.8903738106381951 1.0 1.0 7 P04637 1 +Focal cortical dysplasia 0.5253184218701313 0.1359278960756452 0.8918782822616653 1.0 1.0 2 P42345 1 +Hypogonadism 0.2743035819287793 0.1347170185485572 0.8928356169993048 1.0 1.0 85 O75844,O60313,P02545,P10644,O43175,Q9BT22,P04637,P48651,Q9Y4P3,P00403,P38398,P03886,O95470,O76024 14 +2 3 toe syndactyly 0.2951810648191744 0.1317395033258008 0.8951903386715174 1.0 1.0 31 Q96PU5,P37268,P51812,Q9UHX1,Q15125,O75962,Q9UBM7 7 +Abnormal renal resorption 0.5118085767557636 0.1292197833171905 0.8971837426239593 1.0 1.0 3 P16930,Q01968 2 +Renal fanconi syndrome 0.5118085767557636 0.1292197833171905 0.8971837426239593 1.0 1.0 3 P16930,Q01968 2 +Sudden loss of visual acuity 0.5200372786579563 0.1282862108794768 0.8979224770614249 1.0 1.0 2 O00170 1 +Retinal fold 0.5200372786579524 0.1282862108794709 0.8979224770614296 1.0 1.0 2 P52732 1 +Myositis 0.3360449529314685 0.1271196073336899 0.8988457329472344 1.0 1.0 9 Q9NZ08,P49327,P28070 3 +Polymicrogyria 0.264506935663041 0.1251515094142125 0.9004036052038933 1.0 1.0 76 Q9UBB6,Q9Y289,Q15427,Q15392,Q13509,Q96N66,P55011,P56589,Q10713,P40855,Q9NZ01,O43175,Q9Y320,Q01105,Q8TD16,P23786,P37268,Q9Y487,O75381 19 +Antineutrophil antibody positivity 0.507768800497218 0.1224208189346545 0.9025657513927168 1.0 1.0 3 Q96J02,P49327 2 +Missing ribs 0.3177669437668402 0.1221281639722365 0.9027975172046764 1.0 1.0 13 Q12768,Q14739,O14656,Q96L58 4 +Plantar hyperkeratosis 0.293607304665266 0.1206557875633631 0.9039636794820156 1.0 1.0 30 P02545,Q06136,P42167 3 +Generalized hirsutism 0.292257245730111 0.1187128155249981 0.905502883029407 1.0 1.0 26 P02545,P53634,Q6NUK1,Q04721,Q03252,Q15555,Q06136 7 +Abnormality of the adrenal glands 0.2718608618123095 0.1186339696734558 0.9055653514813288 1.0 1.0 56 P16435,P10644,O75844,P02545,O95470,P04637,Q12768,P40855,Q13423,O75381,P21912 11 +Horizontal ribs 0.5128922025473635 0.1185081640715171 0.9056650266884811 1.0 1.0 2 Q8NCM8 1 +Chronic constipation 0.2925352763587865 0.1179872427893509 0.9060777660537715 1.0 1.0 27 P20700,Q03252,P04062,Q7LGA3,O75962 5 +Cholangitis 0.5116495806150952 0.1168727588801587 0.906960885450678 1.0 1.0 2 Q96J02 1 +Abnormality of the pulmonary vasculature 0.2907167709758263 0.1165713080177512 0.9071997755600734 1.0 1.0 40 Q15392,Q7LGA3,P02545,Q9Y4P3 4 +Rheumatoid factor positive 0.4185427572149611 0.1159169196683113 0.9077183861351376 1.0 1.0 4 Q9UBC1 1 +Aplasia hypoplasia of the eyelid 0.3208213347999709 0.1144734442842561 0.908862496388616 1.0 1.0 12 O43175 1 +Short fourth metatarsal 0.5022696613213044 0.1134851750904561 0.909645915714107 1.0 1.0 3 Q96S52 1 +Abnormal prostate morphology 0.3423538517710572 0.1124966776874809 0.9104296038440798 1.0 1.0 8 P04637 1 +Abnormal monocyte morphology 0.507611059335181 0.1116894930352479 0.9110696105446424 1.0 1.0 2 Q9UJV9 1 +Monocytosis 0.507611059335181 0.1116894930352479 0.9110696105446424 1.0 1.0 2 Q9UJV9 1 +Limb undergrowth 0.2827023733483476 0.1088399418194801 0.913329442993614 1.0 1.0 48 P10644,Q96HY6,O43175,Q15392,P38398,O00116,Q9UHX1,Q15125,Q9UBM7,Q14739 10 +Abnormality of the humeroradial joint 0.3312945156837018 0.1075825717291636 0.9143268224871132 1.0 1.0 9 P16435,P10644,P48651 3 +Facial shape deformation 0.3659011015616101 0.1075667045975833 0.9143394095844624 1.0 1.0 5 O00754,O75431 2 +Hip contracture 0.3147858938892935 0.1074517018580579 0.9144306397388332 1.0 1.0 13 Q96AY3,Q8TD16,O94905,Q7LGA3 4 +Arnold chiari type i malformation 0.4125015287308777 0.1035327484961489 0.9175401595987832 1.0 1.0 4 Q15043 1 +Facial diplegia 0.3183961213334485 0.1031205919474768 0.9178672621354872 1.0 1.0 12 P12235,Q96TA2,O43819 3 +Absent testis 0.4122315309750834 0.1029920157688351 0.9179693077489736 1.0 1.0 4 P38398 1 +Restless legs 0.4116347324998716 0.1018006682824619 0.918914895195022 1.0 1.0 4 P07196 1 +Abnormal length of corpus callosum 0.4992233612923159 0.1015594495759579 0.9191063675132036 1.0 1.0 2 P48449 1 +Corticospinal tract hypoplasia 0.4992233612923107 0.1015594495759518 0.9191063675132084 1.0 1.0 2 Q13045 1 +Abnormal circulating dicarboxylic acid concentration 0.2880151643162124 0.0995624636194484 0.9206916953959006 1.0 1.0 41 Q9H9P8,P28288,Q16134,Q9UJS0,P37268,O75648,P11413,P40855,P22695,P23786,Q14739 11 +Skeletal dysplasia 0.2871929444701613 0.0984285134881187 0.9215920341161452 1.0 1.0 42 P16278,Q96HY6,O95831,Q15427,Q04721,Q96DX4,Q96L58,P56589,P51648,P10619,P40855,O75381,Q14739 13 +Gangrene 0.3216562595371559 0.0983797647547621 0.921630742111408 1.0 1.0 11 Q9NZ08,P10644 2 +Narrow forehead 0.2825036183877778 0.0969874662722366 0.9227363479876676 1.0 1.0 47 P20700,Q9Y296,Q96A33,Q7LGA3,O75787,Q9UHX1,P55011,Q9UBM7 8 +Conspicuously happy disposition 0.4945635290462793 0.0962950557741789 0.9232862377609492 1.0 1.0 2 P55795 1 +Abnormal morphology of myocardial trabeculae 0.4063986612366427 0.0915776487162085 0.927033610553032 1.0 1.0 4 Q99797 1 +Bilateral ptosis 0.3004024820157651 0.0908695367082236 0.9275962562060468 1.0 1.0 16 O60313,O75306,O43819,Q5T8D3 4 +Recurrent skin infections 0.3065824132104347 0.0908404129585591 0.9276193978859172 1.0 1.0 14 Q8NCH0,O00203 2 +Abnormal number of teeth 0.2624625592216299 0.0901900976535758 0.9281361531854526 1.0 1.0 77 O75844,P10644,P02545,Q6NUK1,P20700,Q9Y4P3,O96028,O75962,Q9UHX1,Q5H8A4,O75431,Q9UBM7,O95202 13 +Abnormality of mouth shape 0.2512093767393064 0.0893632884918112 0.9287931982454016 1.0 1.0 66 P10644,Q86XL3,O96028,P04062,P51812,Q96A33,Q10713,Q5H8A4,Q15125,O95202 10 +Occipital encephalocele 0.4049592981074655 0.0888396845623932 0.9292093186436264 1.0 1.0 4 Q10713 1 +Agitation 0.2893994037167969 0.0886246771984686 0.9293801956819708 1.0 1.0 33 P10644,Q15165,P42892,P04062,P05067 5 +Immune dysregulation 0.4861758310034055 0.0874552612140341 0.9303096454997448 1.0 1.0 2 P42224 1 +Hypokalemia 0.3438978125719133 0.087293701606602 0.9304380603007334 1.0 1.0 7 P05023 1 +Aplasia hypoplasia of the ulna 0.3226219427555847 0.0862158659786512 0.9312948184428418 1.0 1.0 10 P38398,P10644,Q9BXW9 3 +Iris hypopigmentation 0.3573943583985023 0.0852565695872281 0.9320574182159604 1.0 1.0 5 O00203,Q05086 2 +Focal onset seizure 0.2679535414136882 0.0847555290586585 0.932455748936325 1.0 1.0 83 Q9UBB4,Q96PU5,P07602,O43175,Q01105,Q9UBX3,P52788,Q9NZJ7,P00403,Q96N66,O75503,P03886,Q9NZ01,P21912 14 +Esophagitis 0.3339604484457562 0.0817822939177353 0.9348198363095874 1.0 1.0 8 O43175 1 +Abnormal cortical bone morphology 0.2942882531719853 0.0813568592337821 0.9351581566752424 1.0 1.0 19 O00754,Q86XL3,P40855,P48651,P51798 5 +Impaired adp induced platelet aggregation 0.4784329477986036 0.0789753922119495 0.9370521960849878 1.0 1.0 3 O00203 1 +Cortical dysplasia 0.2880252702086625 0.0789629865399151 0.9370620635636988 1.0 1.0 31 Q9UBB6,Q96PU5,Q13509,Q96N66,P55011,Q9NZ01 6 +Abnormal blood phosphate concentration 0.3196910056168336 0.0742024111994831 0.9408493272827996 1.0 1.0 10 P51798 1 +Colorectal polyposis 0.322857318862456 0.0741545297270009 0.940887426207488 1.0 1.0 9 P04637,P21912 2 +Lymphoproliferative disorder 0.396642834939397 0.073631438560852 0.9413036546758085 1.0 1.0 4 Q9H0U3,P17812,P33991 3 +Amniotic constriction ring 0.4706430568499404 0.0731516570302553 0.9416854353658386 1.0 1.0 2 Q53GS7 1 +Abnormal urine alpha ketoglutarate concentration 0.3390640582582637 0.0716909883047096 0.9428478280005615 1.0 1.0 7 P09622 1 +Colitis 0.3219178082191759 0.0705365374234355 0.943766620301134 1.0 1.0 9 P49748,P42224,Q6PGP7,P09884,Q15833,P50851,Q13043,P49327 8 +Partial agenesis of the corpus callosum 0.2974748767224331 0.0703007893514963 0.9439542542518268 1.0 1.0 15 Q15392,Q13509,Q9HC21 3 +Oliguria 0.4669151910531182 0.0700989574194367 0.944114896521626 1.0 1.0 2 O43772 1 +Decreased urine output 0.4669151910531182 0.0700989574194367 0.944114896521626 1.0 1.0 2 O43772 1 +Webbed neck 0.2865189781854853 0.0686424554299991 0.94527422399801 1.0 1.0 35 O75844,O95202 2 +Cavum septum pellucidum 0.3108193342811788 0.0686127897223213 0.9452978381342776 1.0 1.0 12 O95202 1 +Periventricular heterotopia 0.3106898571819702 0.0680361489196109 0.9457568582636946 1.0 1.0 12 Q96PU5,Q6NUK1 2 +Eversion of lateral third of lower eyelids 0.4641192917054968 0.0679018307585815 0.9458637813842276 1.0 1.0 2 P61978 1 +Neuronal loss in basal ganglia 0.3501476165257161 0.0673009661898591 0.9463421077264044 1.0 1.0 5 O43819 1 +Thoracic aortic aneurysm 0.2865209406865506 0.0672934310964802 0.9463481062622612 1.0 1.0 33 O75844,Q7LGA3,P02545 3 +Complex febrile seizure 0.4603914259086672 0.0650928029774541 0.9481001106735129 1.0 1.0 2 Q8WVX9 1 +Corneal scarring 0.4667495338719845 0.0645155664633469 0.948559712687498 1.0 1.0 3 Q86XI2,Q03001 2 +Abnormal serum interleukin level 0.4667495338719793 0.0645155664633407 0.9485597126875028 1.0 1.0 3 P49327,Q15833 2 +Overriding aorta 0.3289622840078091 0.0642379454087753 0.9487807637068256 1.0 1.0 8 Q9Y4P3 1 +Rod cone dystrophy 0.2846097924986752 0.0634092583500541 0.9494406149920092 1.0 1.0 39 P40855,P03886,P38435 3 +Narrow foot 0.4569742155948852 0.0626361019544725 0.9500562806446158 1.0 1.0 2 P55263 1 +Blue irides 0.3198156274214581 0.0625190019169395 0.9501495301974257 1.0 1.0 9 P10644,Q15056,Q9Y4P3 3 +Hashimoto thyroiditis 0.4648850217526579 0.0623532293087943 0.9502815400460743 1.0 1.0 3 Q15437,Q96J02 2 +Decreased specific antibody response to protein vaccine 0.455731593662612 0.0617702458469079 0.9507457985985976 1.0 1.0 2 Q13546 1 +Abnormality of the scrotum 0.2793111457998098 0.0603814193818004 0.9518518568380664 1.0 1.0 46 P16435,Q6NUK1,Q69YQ0,Q9Y296,Q7LGA3,P55011,Q9UM00,P46977,Q9UBM7,O60566,Q9Y619 11 +Cervical spinal canal stenosis 0.4532463497980712 0.0600817542242761 0.9520905217273964 1.0 1.0 2 Q8IWS0 1 +Aplasia hypoplasia of the radius 0.2933835387653117 0.0591600991265951 0.9528245902340712 1.0 1.0 17 P10644,Q9BXW9,Q96AY3,P38398,O75962,Q9UBM7 6 +Respiratory insufficiency 0.3476364050502542 0.058923279283328 0.9530132160761866 1.0 1.0 178 Q9BT22,Q96AA3,O43819,P53007,P40855,P03886,P40939,O43676,P07602,Q6NUK1,P50402,Q96CU9,P06280,O14656,Q13510,Q86Y39,O76024,P02545,Q15165,O95831,Q9NR77,Q70HW3,Q8TD16,O95299,P61916,O96000,Q9Y6M9,O75208,P23786,Q14739,P33991,Q5XKP0,Q9Y263,Q9NZJ7,P10253,P53701,Q53H12,P13473,P12235,O75381,Q9Y619 41 +Sloping forehead 0.2791339958954466 0.0588679198279165 0.9530573099904976 1.0 1.0 46 Q9HC21,O43175,Q96J42,Q9BXW9,Q86XL3,P38398,Q15645,P23786,O60566 9 +Female reproductive system neoplasm 0.2865510177537208 0.0585136413376957 0.953339496896228 1.0 1.0 21 P21912,P10644,P04637,Q15645,O60566 5 +Dysphonia 0.2849697572107048 0.0584133184069915 0.9534194063325712 1.0 1.0 36 P20700,O95140,Q9Y4P3,Q99643,Q13510,P53007,P21912,Q96RL7 8 +Abnormality of periauricular region 0.2814501417258804 0.0563480850043228 0.9550645133622128 1.0 1.0 23 Q69YQ0,O96028,Q96S52,Q12768,O95202 5 +Erythrocyte inclusion bodies 0.3863848305875149 0.0563067803229233 0.955097417489589 1.0 1.0 4 P11413,P08865,O14936 3 +Motor regression 0.4464119291705458 0.0557276620766154 0.9555587625885296 1.0 1.0 2 P51659 1 +Heart block 0.2826286809721501 0.0556104542361793 0.9556521361182712 1.0 1.0 25 P02545,P50402,P36543,P04899,P06280,Q8WXH0,Q9H490,P23786 8 +Abnormality of amino acid metabolism 0.4457906182043905 0.0553523268733206 0.9558577752140036 1.0 1.0 2 P18074 1 +Flat nasal alae 0.4457906182043905 0.0553523268733206 0.9558577752140036 1.0 1.0 2 P18074 1 +Abnormal sperm motility 0.4411307859583733 0.0526425944277464 0.958016678556312 1.0 1.0 2 Q86Y56 1 +Bilateral cleft lip 0.4386455420937967 0.0512716989431342 0.95910901940534 1.0 1.0 2 Q9NXE4 1 +Dysarthria 0.3283959748880956 0.0504194215604646 0.9597881599012172 1.0 1.0 154 Q9P0J0,O43681,P07196,Q7KZN9,Q9NW15,O14773,O43819,Q10713,Q5T8D3,Q96RL7,P07602,Q96CU9,Q9Y4P3,O14656,P51648,P35670,O15118,O76024,P20700,O95299,P04062,P61916,O75503,Q14108,Q9H6K4,Q9UBB4,Q13144,Q5XKP0,P52788,Q9NZJ7,O94905,Q8IV08,P12235 33 +Reduced consciousness confusion 0.3031377315036237 0.0501438011714012 0.9600077953324466 1.0 1.0 124 Q9HC21,O43681,P09622,O43819,P03886,P40939,Q16836,O43676,P07602,Q96CU9,P00403,P05067,Q86Y39,P50416,Q13423,O96008,Q9UBM7,P35670,Q9NZ08,Q96IX5,P04062,O96000,Q9Y6M9,P23786,Q9UJS0,Q9NZJ7,P12235,Q5H8A4,Q9Y619 29 +Episodic ataxia 0.4524549409571262 0.048931624104169 0.9609737866487416 1.0 1.0 3 P08559,O14936 2 +Abnormal blood inorganic cation concentration 0.2806408707422734 0.0448546125674785 0.9642231943291656 1.0 1.0 42 P10644,Q9Y4P3,Q15043,O75962,P05023,P40939,P51798,P21964 8 +Abnormal ossification involving the femoral head and neck 0.4472957158068795 0.0438562471139176 0.9650189914651264 1.0 1.0 3 Q14739 1 +Abnormal erythrocyte sedimentation rate 0.3297594914311683 0.0430821556714621 0.9656360438025902 1.0 1.0 7 O15460,Q9UBC1,P28070,P14174 4 +Hiatus hernia 0.3043195525011153 0.0402297239386289 0.96790998052944 1.0 1.0 12 Q8NCH0 1 +Abnormality of the epiphyses of the distal phalanx of finger 0.413171792482133 0.0399146788351211 0.9681611484111234 1.0 1.0 2 Q9Y2Q9 1 +Pulmonary artery stenosis 0.2907058878880749 0.0396627684518631 0.9683619847768672 1.0 1.0 16 Q9Y4P3 1 +Supernumerary nipple 0.3074840145804356 0.0384289650377062 0.969345667272682 1.0 1.0 11 Q9UM00,Q7LGA3,Q15233 3 +Single fiber emg abnormality 0.4072693383038206 0.0379067601277274 0.9697620231220944 1.0 1.0 2 O75340 1 +Muscle fiber tubular inclusions 0.4072693383038206 0.0379067601277274 0.9697620231220944 1.0 1.0 2 O75340 1 +Decreased size of nerve terminals 0.4072693383038198 0.0379067601277271 0.9697620231220944 1.0 1.0 2 P11047 1 +Abnormality of skin physiology 0.2760735525132671 0.0346361197807987 0.9723698993492836 1.0 1.0 96 P21912,P22830,Q5JRA6,Q9UBM7,Q9NZ08,Q8NCH0,Q92542,P10321,Q96A33,Q14739,Q15800,Q99828,Q15125,P16615,Q06136,P35670,P21964,O00203 18 +Abnormal tracheal morphology 0.2817509448833938 0.0331449230215202 0.9735590190223248 1.0 1.0 35 Q96HY6,Q9BXW9,Q9Y4P3,Q96L58,P38398,P55011,Q15125,Q9UBM7,Q14739 9 +Aplasia hypoplasia of the 4th metacarpal 0.4341717749199582 0.0321976280582946 0.9743144477352408 1.0 1.0 3 Q14739 1 +Abnormality of the 4th metacarpal 0.4341717749199582 0.0321976280582946 0.9743144477352408 1.0 1.0 3 Q14739 1 +Reduced forced expiratory volume in one second 0.3839701770736193 0.0318260812611413 0.9746107473298866 1.0 1.0 2 Q96J02 1 +Anti thyroid peroxidase antibody positivity 0.38365952159055 0.0317624312122045 0.9746615070588708 1.0 1.0 2 Q96J02 1 +Supraventricular arrhythmia 0.2856858188036369 0.0316539448119783 0.9747480231796408 1.0 1.0 19 P50402,P02545 2 +Renal hypoplasia 0.2814930018543174 0.0307276426170346 0.9754867459468266 1.0 1.0 33 Q9UBM7,P21964,Q9UHX1,Q9Y4P3 4 +Nocturnal hypoventilation 0.3774464119291733 0.0305726110445494 0.975610385155976 1.0 1.0 2 P61978 1 +Facial erythema 0.3703013358185796 0.0293868936083168 0.97655602567693 1.0 1.0 2 O00170 1 +Astrocytosis 0.3300155520995227 0.0286049129204735 0.9771796937452746 1.0 1.0 6 Q9UQN3,P42345,P55265,P54098,P55072 5 +Skull asymmetry 0.364709537123328 0.028581947559963 0.9771980099628026 1.0 1.0 2 Q96DX4 1 +Cone shaped epiphysis 0.297727289077088 0.0280450465715969 0.9776262232930656 1.0 1.0 13 P10644,Q5JRA6,O95831,Q96DX4 4 +Increased nuchal translucency 0.288398323309194 0.0279088905530886 0.9777348175707374 1.0 1.0 16 Q15645,Q9UBM7,Q9Y4P3 3 +Persistent ebv viremia 0.3591177384280834 0.0278743604840099 0.9777623578652672 1.0 1.0 2 Q9H0U3 1 +X linked recessive inheritance 0.2686205581279894 0.0272936261212859 0.9782255405947128 1.0 1.0 52 O95831,P50402,P51572,Q9NVH6,P52788,P06280,Q15233,Q15904,O75787,P46020,P51571,Q15125,Q04656 13 +Pustule 0.4276929440144989 0.0270772163503033 0.978398146815598 1.0 1.0 3 Q99828 1 +Weakness of long finger extensor muscles 0.3507300403852165 0.0269755613106482 0.9784792261855964 1.0 1.0 2 Q9Y223 1 +Abnormal oral glucose tolerance 0.3501087294190797 0.0269160709393573 0.978526675405338 1.0 1.0 2 Q9UKG1 1 +Transient neonatal diabetes mellitus 0.3501087294190797 0.0269160709393573 0.978526675405338 1.0 1.0 2 Q9UKG1 1 +Hypoinsulinemia 0.3501087294190797 0.0269160709393573 0.978526675405338 1.0 1.0 2 Q9UKG1 1 +Chronic noninfectious lymphadenopathy 0.3423423423423473 0.0262464767062327 0.979060745585232 1.0 1.0 2 P49327 1 +Aplasia hypoplasia involving forearm bones 0.2847127043571418 0.0261845181346341 0.9791101643884008 1.0 1.0 19 P10644,Q9BXW9,Q96AY3,P38398,O75962,Q9UBM7 6 +Synostosis involving bones of the upper limbs 0.2805448541446959 0.0256132568862512 0.9795658120734658 1.0 1.0 31 P16435,Q9Y4P3,Q96L58,O96028,Q15233,P48651,Q04656,O95202 8 +Platyspondyly 0.2804633419375781 0.0246895967702358 0.9803025531273404 1.0 1.0 36 O00754,P16278,P34059,Q6NUK1,Q5JRA6,O95831,Q96HY6,Q96AY3,Q96DX4,Q96L58,Q9Y2Q9,Q6NUQ1,Q14739,Q04656,Q01968 15 +Long penis 0.305374339857097 0.02445145921056 0.9804925020633332 1.0 1.0 2 O00170 1 +Small basal ganglia 0.3165942010639174 0.023338504277171 0.981380258098469 1.0 1.0 8 Q13509,Q96RL7,P22570 3 +Small epiphyses 0.3625775068980024 0.022107481172493 0.9823622188229192 1.0 1.0 4 O95831 1 +Abnormal circulating sex hormone concentration 0.2822490761339506 0.0212467819404805 0.9830487961008418 1.0 1.0 20 Q13423,P04637,P16435 3 +Recurrent hand flapping 0.4169079669182443 0.0194303449278844 0.9844978032226172 1.0 1.0 3 Q05086 1 +Neoplasm of the liver 0.2788968400480391 0.0191434077683882 0.9847267033738044 1.0 1.0 39 P10644,Q9UJS0,P04637,Q5HYI8,Q10713,Q15645,P35670 7 +Cutaneous abscess 0.3593410009325552 0.0180896826978069 0.9855673086207476 1.0 1.0 4 O14920,P53634,Q13546 3 +Decreased proportion of cd4 positive helper t cells 0.3593410009325536 0.018089682697805 0.985567308620749 1.0 1.0 4 Q9H0U3,O14920,P49327 3 +Abnormality of metacarpophalangeal joint 0.35933143891322 0.0180780302908921 0.9855766043762204 1.0 1.0 4 P16435 1 +Portal fibrosis 0.3590301523158287 0.0177115329080258 0.9858689801614442 1.0 1.0 4 Q9H3U1,P28288,P55263 3 +Cardiac arrest 0.2795100986333897 0.0165640686773754 0.986784389665254 1.0 1.0 33 P02545,P50402,Q9Y4P3,O14656,P04062,P50416 6 +Basal ganglia gliosis 0.3140899638052782 0.0155079215642131 0.987626964759247 1.0 1.0 8 O43819 1 +Neonatal hypoglycemia 0.2984178906760374 0.0154901683901741 0.987641128041461 1.0 1.0 12 P40939 1 +Abnormality of the forearm 0.273990282665308 0.0154717655067882 0.9876558096585826 1.0 1.0 46 P16435,P10644,Q15427,Q9BXW9,Q96AY3,Q04721,Q9Y4P3,Q96L58,O96028,P38398,Q15056,P48651,O75962,Q9UBM7,O95202 15 +Response to drugs acting on neuromuscular transmission 0.4073958980733489 0.0135419235618526 0.9891954384975008 1.0 1.0 3 P11047,O75340 2 +Emg decremental response of compound muscle action potential to repetitive nerve stimulation 0.4073958980733489 0.0135419235618526 0.9891954384975008 1.0 1.0 3 P11047,O75340 2 +Dental malocclusion 0.2748254152438478 0.013391992995053 0.9893150549345822 1.0 1.0 23 P10644,Q9Y4P3,P38398,P51812,P51798 5 +Spina bifida occulta 0.2818759943397702 0.010427256054938 0.9916804041442104 1.0 1.0 19 Q9UHX1 1 +Cutaneous cyst 0.401491609695476 0.0102647179796864 0.9918100838242472 1.0 1.0 3 O60716,Q8TAA9 2 +Delayed social development 0.4008701056557041 0.0099358636475449 0.9920724582339152 1.0 1.0 3 Q9Y2V7,Q13509 2 +Limb dystonia 0.2847159892730082 0.0095158844729063 0.9924075372823772 1.0 1.0 16 Q99720 1 +Duodenal atresia 0.3221292390795154 0.0092875355392002 0.992589725318487 1.0 1.0 6 Q15645 1 +Tip toe gait 0.3991047425393758 0.0090181125396712 0.9928046847652712 1.0 1.0 3 O75477 1 +Gastritis 0.321517412935319 0.0060880759582432 0.9951424481951994 1.0 1.0 5 P50851,Q6PGP7,Q13546,P49327 4 +Abnormality of iron homeostasis 0.3215174129353182 0.0060880759582415 0.9951424481952008 1.0 1.0 5 Q6PGP7,Q9Y276,P28288,Q02241 4 +Severe expressive language delay 0.3925699261171452 0.0058258633410001 0.9953516598815236 1.0 1.0 3 Q96DX4 1 +Abnormality of the chin 0.2578493938877336 0.0050258121164499 0.9959899989880896 1.0 1.0 80 Q9NVI7,P34059,Q7LGA3,Q9UHX1,P55011,P10644,O00754,P16278,Q6NUK1,Q9Y4P3,P48651,Q01968,O75844,P02545,P20700,Q69YQ0,P36543,P51812,Q15056,Q05086,Q04721,P52788,Q96S52,O75962 24 +Respiratory failure requiring assisted ventilation 0.3205972192206568 0.0043807299479495 0.9965046943891034 1.0 1.0 5 P10253 1 +Poikilocytosis 0.2840054603965978 0.0038605699865834 0.9969197184632276 1.0 1.0 15 Q9NP58,O14656,Q96RL7 3 +Large intestinal polyposis 0.3012173601468621 0.0035799884141056 0.9971435886179788 1.0 1.0 10 Q99643,P04637,P78549,P21912 4 +Alopecia 0.2757966422361855 0.002090057216654 0.9983323768297612 1.0 1.0 41 O75844,P02545,Q15125,O75431,Q06136 5 diff --git a/msigdb_hp/selections.json b/msigdb_hp/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..1cd445b0994a2bb18e262a57561d4919d644bfd5 --- /dev/null +++ b/msigdb_hp/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["11 pairs of ribs", "2 3 finger syndactyly", "2 3 toe cutaneous syndactyly", "2 3 toe syndactyly", "3 4 finger syndactyly", "3 methylglutaconic aciduria", "4 5 toe syndactyly", "Abdominal aortic aneurysm", "Abdominal distention", "Abdominal obesity", "Abdominal pain", "Abdominal wall muscle weakness", "Abducens palsy", "Abnormal 2nd finger morphology", "Abnormal 3rd finger morphology", "Abnormal 5th finger morphology", "Abnormal 5th finger phalanx morphology", "Abnormal abdomen morphology", "Abnormal acetabulum morphology", "Abnormal activity of mitochondrial respiratory chain", "Abnormal adipose tissue morphology", "Abnormal aggressive impulsive or violent behavior", "Abnormal aldolase level", "Abnormal anatomic location of the heart", "Abnormal anterior chamber morphology", "Abnormal anterior eye segment morphology", "Abnormal anterior horn cell morphology", "Abnormal aortic arch morphology", "Abnormal aortic morphology", "Abnormal aortic valve cusp morphology", "Abnormal aortic valve morphology", "Abnormal aortic valve physiology", "Abnormal arachnoid mater morphology", "Abnormal arm span", "Abnormal arterial physiology", "Abnormal astrocyte morphology", "Abnormal atrial arrangement", "Abnormal atrioventricular conduction", "Abnormal atrioventricular valve morphology", "Abnormal atrioventricular valve physiology", "Abnormal auditory evoked potentials", "Abnormal autonomic nervous system physiology", "Abnormal b cell morphology", "Abnormal b cell subset distribution", "Abnormal basal ganglia mri signal intensity", "Abnormal basophil morphology", "Abnormal biliary tract morphology", "Abnormal bleeding", "Abnormal blistering of the skin", "Abnormal blood carbon dioxide level", "Abnormal blood chloride concentration", "Abnormal blood gas level", "Abnormal blood glucose concentration", "Abnormal blood inorganic cation concentration", "Abnormal blood ion concentration", "Abnormal blood monovalent inorganic cation concentration", "Abnormal blood phosphate concentration", "Abnormal blood potassium concentration", "Abnormal blood sodium concentration", "Abnormal blood transition element cation concentration", "Abnormal blood zinc concentration", "Abnormal bone structure", "Abnormal brain choline level by mrs", "Abnormal brain lactate level by mrs", "Abnormal brain n acetyl aspartate level by mrs", "Abnormal brain positron emission tomography", "Abnormal brainstem morphology", "Abnormal brainstem mri signal intensity", "Abnormal branching pattern of the aortic arch", "Abnormal breath sound", "Abnormal bronchoalveolar lavage fluid morphology", "Abnormal bronchus morphology", "Abnormal bronchus physiology", "Abnormal c peptide level", "Abnormal c reactive protein level", "Abnormal calcification of the carpal bones", "Abnormal calcium phosphate regulating hormone level", "Abnormal cardiac atrium morphology", "Abnormal cardiac exercise stress test", "Abnormal cardiac septum morphology", "Abnormal cardiac test", "Abnormal cardiac ventricle morphology", "Abnormal cardiac ventricular function", "Abnormal cardiomyocyte morphology", "Abnormal carotid artery morphology", "Abnormal cartilage morphology", "Abnormal caudate nucleus morphology", "Abnormal cd4 cd8 ratio", "Abnormal cell morphology", "Abnormal cell proliferation", "Abnormal cellular composition of bronchoalveolar fluid", "Abnormal cellular phenotype", "Abnormal central sensory function", "Abnormal cerebellar vermis morphology", "Abnormal cerebral artery morphology", "Abnormal cerebral cortex morphology", "Abnormal cerebral vascular morphology", "Abnormal cerebral vein morphology", "Abnormal cerebral ventricle morphology", "Abnormal cerebrospinal fluid metabolite concentration", "Abnormal cervical curvature", "Abnormal cervical spine morphology", "Abnormal chorioretinal morphology", "Abnormal choroid morphology", "Abnormal choroid plexus morphology", "Abnormal chromosome morphology", "Abnormal ciliary body morphology", "Abnormal circulating acetylcarnitine concentration", "Abnormal circulating albumin concentration", "Abnormal circulating amino acid concentration", "Abnormal circulating amylase level", "Abnormal circulating androgen level", "Abnormal circulating apolipoprotein concentration", "Abnormal circulating arginine concentration", "Abnormal circulating aromatic amino acid concentration", "Abnormal circulating aspartate family amino acid concentration", "Abnormal circulating bilirubin concentration", "Abnormal circulating branched chain amino acid concentration", "Abnormal circulating carbohydrate concentration", "Abnormal circulating carboxylic acid concentration", "Abnormal circulating ceruloplasmin concentration", "Abnormal circulating cholesterol concentration", "Abnormal circulating citrulline concentration", "Abnormal circulating copper concentration", "Abnormal circulating creatinine concentration", "Abnormal circulating dehydroepiandrosterone concentration", "Abnormal circulating dicarboxylic acid concentration", "Abnormal circulating estrogen level", "Abnormal circulating fatty acid anion concentration", "Abnormal circulating fatty acid concentration", "Abnormal circulating ferritin concentration", "Abnormal circulating follicle stimulating hormone concentration", "Abnormal circulating free fatty acid concentration", "Abnormal circulating gaba concentration", "Abnormal circulating glutamine concentration", "Abnormal circulating glutamine family amino acid concentration", "Abnormal circulating glycine concentration", "Abnormal circulating gonadotropin concentration", "Abnormal circulating hormone concentration", "Abnormal circulating iga level", "Abnormal circulating ige level", "Abnormal circulating igg level", "Abnormal circulating igm level", "Abnormal circulating inhibin level", "Abnormal circulating lipid concentration", "Abnormal circulating long chain fatty acid concentration", "Abnormal circulating metabolite concentration", "Abnormal circulating methionine concentration", "Abnormal circulating monocarboxylic acid cocentration", "Abnormal circulating nitrogen compound concentration", "Abnormal circulating non proteinogenic amino acid concentration", "Abnormal circulating nucleobase concentration", "Abnormal circulating phenylalanine concentration", "Abnormal circulating porphyrin concentration", "Abnormal circulating progesterone level", "Abnormal circulating proline concentration", "Abnormal circulating protein concentration", "Abnormal circulating proteinogenic amino acid concentration", "Abnormal circulating proteinogenic amino acid derivative concentration", "Abnormal circulating pyruvate family amino acid concentration", "Abnormal circulating renin", "Abnormal circulating serine concentration", "Abnormal circulating serine family amino acid concentration", "Abnormal circulating sex hormone concentration", "Abnormal circulating sulfur amino acid concentration", "Abnormal circulating tyrosine concentration", "Abnormal clavicle morphology", "Abnormal cns myelination", "Abnormal cochlea morphology", "Abnormal conjugate eye movement", "Abnormal conjunctiva morphology", "Abnormal connection of the cardiac segments", "Abnormal consumption behavior", "Abnormal conus terminalis morphology", "Abnormal cornea morphology", "Abnormal corneal endothelium morphology", "Abnormal corneal epithelium morphology", "Abnormal coronary artery morphology", "Abnormal corpus callosum morphology", "Abnormal corpus striatum morphology", "Abnormal cortical bone morphology", "Abnormal cortical gyration", "Abnormal cranial nerve morphology", "Abnormal cranial nerve physiology", "Abnormal cry", "Abnormal csf carboxylic acid concentration", "Abnormal csf metabolite level", "Abnormal csf protein level", "Abnormal csf pyruvate family amino acid concentration", "Abnormal cutaneous elastic fiber morphology", "Abnormal delayed hypersensitivity skin test", "Abnormal delivery", "Abnormal dense granules", "Abnormal dental pulp morphology", "Abnormal dental root morphology", "Abnormal dentate nucleus morphology", "Abnormal dentin morphology", "Abnormal dermatoglyphics", "Abnormal dermoepidermal junction morphology", "Abnormal descemet membrane morphology", "Abnormal diaphysis morphology", "Abnormal distal phalanx morphology of finger", "Abnormal dlco", "Abnormal drinking behavior", "Abnormal duodenum morphology", "Abnormal dura mater morphology", "Abnormal eating behavior", "Abnormal echocardiogram", "Abnormal elasticity of skin", "Abnormal electrophysiology of sinoatrial node origin", "Abnormal electroretinogram", "Abnormal emotion affect behavior", "Abnormal enchondral ossification", "Abnormal endocardium morphology", "Abnormal endocrine physiology", "Abnormal enzyme coenzyme activity", "Abnormal eosinophil morphology", "Abnormal epidermal morphology", "Abnormal epiglottis morphology", "Abnormal epiphyseal ossification", "Abnormal epiphysis morphology of the phalanges of the hand", "Abnormal erythrocyte enzyme level", "Abnormal erythrocyte morphology", "Abnormal erythrocyte physiology", "Abnormal erythrocyte sedimentation rate", "Abnormal esophagus morphology", "Abnormal esophagus physiology", "Abnormal external genitalia", "Abnormal exteroceptive sensation", "Abnormal eyebrow morphology", "Abnormal eyelash morphology", "Abnormal eyelid morphology", "Abnormal eyelid physiology", "Abnormal facial expression", "Abnormal facial shape", "Abnormal factor ix activity", "Abnormal fallopian tube morphology", "Abnormal fear anxiety related behavior", "Abnormal female reproductive system physiology", "Abnormal femoral head morphology", "Abnormal femoral neck head morphology", "Abnormal femoral neck morphology", "Abnormal finger phalanx morphology", "Abnormal fingernail morphology", "Abnormal fingertip morphology", "Abnormal foot bone ossification", "Abnormal foramen magnum morphology", "Abnormal forearm bone morphology", "Abnormal form of the vertebral bodies", "Abnormal foveal morphology", "Abnormal full field electroretinogram", "Abnormal fundus autofluorescence imaging", "Abnormal gallbladder morphology", "Abnormal gastrointestinal motility", "Abnormal glial cell morphology", "Abnormal globus pallidus morphology", "Abnormal glomerular basement membrane morphology", "Abnormal glomerular filtration rate", "Abnormal glomerular mesangial cellularity", "Abnormal glomerular mesangium morphology", "Abnormal glucose homeostasis", "Abnormal glycosylation", "Abnormal granulocyte count", "Abnormal granulocytopoietic cell morphology", "Abnormal greater sciatic notch morphology", "Abnormal growth hormone level", "Abnormal hair laboratory examination", "Abnormal hair morphology", "Abnormal hair pattern", "Abnormal hair quantity", "Abnormal hair whorl", "Abnormal hand bone ossification", "Abnormal hand morphology", "Abnormal hdl cholesterol concentration", "Abnormal head movements", "Abnormal heart rate variability", "Abnormal heart sound", "Abnormal heart valve morphology", "Abnormal heart valve physiology", "Abnormal hemidiaphragm morphology", "Abnormal hemoglobin", "Abnormal hemoglobin concentration", "Abnormal hepatic iron concentration", "Abnormal humerus morphology", "Abnormal hypothalamus morphology", "Abnormal hypothalamus physiology", "Abnormal ileum morphology", "Abnormal iliac wing morphology", "Abnormal ilium morphology", "Abnormal immune system morphology", "Abnormal incisor morphology", "Abnormal inflammatory response", "Abnormal insulin level", "Abnormal internal carotid artery morphology", "Abnormal internal genitalia", "Abnormal intestine morphology", "Abnormal intraocular pressure", "Abnormal involuntary eye movements", "Abnormal iris pigmentation", "Abnormal jaw morphology", "Abnormal joint morphology", "Abnormal labia majora morphology", "Abnormal labia minora morphology", "Abnormal labia morphology", "Abnormal lacrimal duct morphology", "Abnormal lacrimal gland morphology", "Abnormal lactate dehydrogenase level", "Abnormal large intestine morphology", "Abnormal large intestine physiology", "Abnormal larynx morphology", "Abnormal larynx physiology", "Abnormal lateral ventricle morphology", "Abnormal ldl cholesterol concentration", "Abnormal left atrium morphology", "Abnormal left ventricle morphology", "Abnormal left ventricular outflow tract morphology", "Abnormal length of corpus callosum", "Abnormal leukocyte count", "Abnormal leukocyte physiology", "Abnormal levels of alpha fetoprotein", "Abnormal libido", "Abnormal light and dark adapted electroretinogram", "Abnormal lip morphology", "Abnormal liver morphology", "Abnormal liver parenchyma morphology", "Abnormal liver physiology", "Abnormal localization of kidney", "Abnormal location of ears", "Abnormal lower limb bone morphology", "Abnormal lower motor neuron morphology", "Abnormal lumbar spine morphology", "Abnormal lung development", "Abnormal lung lobation", "Abnormal lymphatic vessel morphology", "Abnormal lymphocyte morphology", "Abnormal macrophage morphology", "Abnormal macroscopic urine appearance", "Abnormal macular morphology", "Abnormal magnesium concentration", "Abnormal male reproductive system physiology", "Abnormal mandibular ramus morphology", "Abnormal mean corpuscular hemoglobin concentration", "Abnormal mean corpuscular volume", "Abnormal megakaryocyte morphology", "Abnormal meningeal morphology", "Abnormal metabolic brain imaging by mrs", "Abnormal metabolism", "Abnormal metacarpal morphology", "Abnormal metaphyseal trabeculation", "Abnormal metatarsal morphology", "Abnormal midbrain morphology", "Abnormal middle phalanx morphology of the hand", "Abnormal mitochondria in muscle tissue", "Abnormal mitochondrial morphology", "Abnormal mitochondrial number", "Abnormal mitochondrial shape", "Abnormal mitral valve physiology", "Abnormal monocyte morphology", "Abnormal morphology of myocardial trabeculae", "Abnormal morphology of the abdominal musculature", "Abnormal morphology of the choroidal vasculature", "Abnormal morphology of the conjunctival vasculature", "Abnormal morphology of the great vessels", "Abnormal morphology of the limbic system", "Abnormal morphology of the musculature of the neck", "Abnormal morphology of the olfactory bulb", "Abnormal morphology of the radius", "Abnormal motor evoked potentials", "Abnormal motor nerve conduction velocity", "Abnormal muscle fiber morphology", "Abnormal muscle fiber protein expression", "Abnormal muscle fiber type distribution", "Abnormal muscle glycogen content", "Abnormal myelination", "Abnormal myeloid cell morphology", "Abnormal myeloid leukocyte morphology", "Abnormal myocardium morphology", "Abnormal nasal base", "Abnormal nasal bridge morphology", "Abnormal nasal mucosa morphology", "Abnormal nasolacrimal system morphology", "Abnormal natural killer cell morphology", "Abnormal natural killer cell physiology", "Abnormal nephron morphology", "Abnormal nerve conduction velocity", "Abnormal nervous system electrophysiology", "Abnormal neural tube morphology", "Abnormal neuron morphology", "Abnormal neutrophil count", "Abnormal nipple morphology", "Abnormal number of erythroid precursors", "Abnormal number of granulocyte precursors", "Abnormal number of incisors", "Abnormal number of permanent teeth", "Abnormal number of teeth", "Abnormal odontoid tissue morphology", "Abnormal optical coherence tomography", "Abnormal oral frenulum morphology", "Abnormal oral glucose tolerance", "Abnormal oral mucosa morphology", "Abnormal oral physiology", "Abnormal ossification involving the femoral head and neck", "Abnormal ovarian morphology", "Abnormal ovarian physiology", "Abnormal palate morphology", "Abnormal palmar dermatoglyphics", "Abnormal pancreas morphology", "Abnormal pancreas size", "Abnormal paranasal sinus morphology", "Abnormal parietal bone morphology", "Abnormal parotid gland morphology", "Abnormal patella morphology", "Abnormal pattern of respiration", "Abnormal pelvis bone morphology", "Abnormal pelvis bone ossification", "Abnormal penis morphology", "Abnormal pericardium morphology", "Abnormal perifollicular morphology", "Abnormal peripheral action potential amplitude", "Abnormal peripheral myelination", "Abnormal peripheral nervous system morphology", "Abnormal peripheral nervous system physiology", "Abnormal peristalsis", "Abnormal periventricular white matter morphology", "Abnormal phalangeal joint morphology of the hand", "Abnormal pharynx morphology", "Abnormal pigmentation of the oral mucosa", "Abnormal pineal morphology", "Abnormal placenta morphology", "Abnormal placental membrane morphology", "Abnormal placental size", "Abnormal platelet aggregation", "Abnormal platelet function", "Abnormal platelet granules", "Abnormal platelet morphology", "Abnormal platelet volume", "Abnormal pleura morphology", "Abnormal pons morphology", "Abnormal posterior segment imaging", "Abnormal posturing", "Abnormal pr interval", "Abnormal preputium morphology", "Abnormal prolactin level", "Abnormal proportion of cd4 positive t cells", "Abnormal proportion of cd8 positive t cells", "Abnormal proportion of class switched memory b cells", "Abnormal proportion of double negative alpha beta regulatory t cell", "Abnormal prostate morphology", "Abnormal protein glycosylation", "Abnormal protein o linked glycosylation", "Abnormal proximal phalanx morphology of the hand", "Abnormal pulmonary interstitial morphology", "Abnormal pulmonary thoracic imaging finding", "Abnormal pulmonary valve morphology", "Abnormal pulmonary valve physiology", "Abnormal pupil morphology", "Abnormal pupillary function", "Abnormal pupillary light reflex", "Abnormal pyramidal sign", "Abnormal qrs complex", "Abnormal qt interval", "Abnormal rectum morphology", "Abnormal reflex", "Abnormal renal collecting system morphology", "Abnormal renal cortex morphology", "Abnormal renal corticomedullary differentiation", "Abnormal renal echogenicity", "Abnormal renal insterstitial morphology", "Abnormal renal medulla morphology", "Abnormal renal morphology", "Abnormal renal pelvis morphology", "Abnormal renal physiology", "Abnormal renal resorption", "Abnormal renal tubule morphology", "Abnormal renal vascular morphology", "Abnormal respiratory motile cilium morphology", "Abnormal respiratory motile cilium physiology", "Abnormal respiratory system morphology", "Abnormal response to acth stimulation test", "Abnormal response to endocrine stimulation test", "Abnormal response to insulin tolerance test", "Abnormal reticulocyte morphology", "Abnormal retinal artery morphology", "Abnormal retinal morphology", "Abnormal retinal vascular morphology", "Abnormal rib cage morphology", "Abnormal rib ossification", "Abnormal right atrium morphology", "Abnormal right ventricle morphology", "Abnormal saccadic eye movements", "Abnormal sacroiliac joint morphology", "Abnormal sacrum morphology", "Abnormal salivary gland morphology", "Abnormal sarcomere morphology", "Abnormal scalp morphology", "Abnormal scapula morphology", "Abnormal sclera morphology", "Abnormal scrotal rugation", "Abnormal sella turcica morphology", "Abnormal sensory nerve conduction velocity", "Abnormal serum insulin like growth factor 1 level", "Abnormal serum interferon level", "Abnormal serum interleukin level", "Abnormal serum iron concentration", "Abnormal sex determination", "Abnormal shape of the frontal region", "Abnormal shape of the occiput", "Abnormal shape of the palpebral fissure", "Abnormal sharpey fiber morphology", "Abnormal shoulder morphology", "Abnormal shoulder physiology", "Abnormal size of pituitary gland", "Abnormal size of the clitoris", "Abnormal size of the palpebral fissures", "Abnormal skin morphology of the palm", "Abnormal social behavior", "Abnormal soft palate morphology", "Abnormal speech prosody", "Abnormal sperm motility", "Abnormal spermatogenesis", "Abnormal spinal meningeal morphology", "Abnormal sputum", "Abnormal st segment", "Abnormal sternal ossification", "Abnormal sternum morphology", "Abnormal stomach morphology", "Abnormal stool composition", "Abnormal subarachnoid space morphology", "Abnormal subclavian artery morphology", "Abnormal subcutaneous fat tissue distribution", "Abnormal substantia nigra morphology", "Abnormal superior cerebellar peduncle morphology", "Abnormal sweat gland morphology", "Abnormal sweat homeostasis", "Abnormal synaptic transmission at the neuromuscular junction", "Abnormal systemic arterial morphology", "Abnormal systemic blood pressure", "Abnormal t cell activation", "Abnormal t cell morphology", "Abnormal t cell proliferation", "Abnormal t cell subset distribution", "Abnormal t wave", "Abnormal talus morphology", "Abnormal tarsal ossification", "Abnormal temper tantrums", "Abnormal temporal bone morphology", "Abnormal tendon morphology", "Abnormal testis morphology", "Abnormal thalamic mri signal intensity", "Abnormal thalamic size", "Abnormal thoracic spine morphology", "Abnormal thorax morphology", "Abnormal thrombocyte morphology", "Abnormal thrombosis", "Abnormal thumb morphology", "Abnormal thyroid hormone level", "Abnormal thyroid morphology", "Abnormal thyroid stimulating hormone level", "Abnormal tissue metabolite concentration", "Abnormal toenail morphology", "Abnormal tongue morphology", "Abnormal tongue physiology", "Abnormal trabecular bone morphology", "Abnormal tracheal morphology", "Abnormal tracheobronchial morphology", "Abnormal transferrin saturation", "Abnormal tricuspid valve morphology", "Abnormal tricuspid valve physiology", "Abnormal umbilicus morphology", "Abnormal upper limb bone morphology", "Abnormal upper motor neuron morphology", "Abnormal ureter morphology", "Abnormal ureter physiology", "Abnormal urinary color", "Abnormal urinary electrolyte concentration", "Abnormal urine alpha ketoglutarate concentration", "Abnormal urine carbohydrate level", "Abnormal urine carboxylic acid level", "Abnormal urine cytology", "Abnormal urine hormone level", "Abnormal urine magnesium concentration", "Abnormal urine metabolite level", "Abnormal urine ph", "Abnormal urine phosphate concentration", "Abnormal urine potassium concentration", "Abnormal urine protein level", "Abnormal urine sodium concentration", "Abnormal uterus morphology", "Abnormal uvea morphology", "Abnormal uvula morphology", "Abnormal vagina morphology", "Abnormal vascular morphology", "Abnormal vascular physiology", "Abnormal vena cava morphology", "Abnormal venous morphology", "Abnormal ventricular septum morphology", "Abnormal vertebral morphology", "Abnormal vertebral segmentation and fusion", "Abnormal vestibulo ocular reflex", "Abnormal visual electrophysiology", "Abnormal visual field test", "Abnormal visual fixation", "Abnormal vitamin b12 level", "Abnormal vitreous humor morphology", "Abnormal waist to hip ratio", "Abnormal z disc morphology", "Abnormalities of placenta or umbilical cord", "Abnormality iris morphology", "Abnormality of abdominal situs", "Abnormality of acid base homeostasis", "Abnormality of adrenal morphology", "Abnormality of adrenal physiology", "Abnormality of alkaline phosphatase level", "Abnormality of amino acid metabolism", "Abnormality of bladder morphology", "Abnormality of blood circulation", "Abnormality of blood volume homeostasis", "Abnormality of body mass index", "Abnormality of bone marrow cell morphology", "Abnormality of bone mineral density", "Abnormality of canine", "Abnormality of cardiovascular system electrophysiology", "Abnormality of carpal bone ossification", "Abnormality of cartilage of external ear", "Abnormality of central nervous system electrophysiology", "Abnormality of chorioretinal pigmentation", "Abnormality of chromosome segregation", "Abnormality of chromosome stability", "Abnormality of circulating adrenocorticotropin level", "Abnormality of circulating enzyme level", "Abnormality of circulating fibrinogen", "Abnormality of circulating glucocorticoid level", "Abnormality of circulating leptin level", "Abnormality of coagulation", "Abnormality of complement system", "Abnormality of coordination", "Abnormality of corneal size", "Abnormality of corneal stroma", "Abnormality of corneal thickness", "Abnormality of cranial sutures", "Abnormality of cytokine secretion", "Abnormality of dental color", "Abnormality of dental eruption", "Abnormality of dental morphology", "Abnormality of dental structure", "Abnormality of dermal melanosomes", "Abnormality of digestive system morphology", "Abnormality of dna repair", "Abnormality of earlobe", "Abnormality of endocrine pancreas physiology", "Abnormality of epiphysis morphology", "Abnormality of exocrine pancreas physiology", "Abnormality of extrapyramidal motor function", "Abnormality of facial adipose tissue", "Abnormality of facial musculature", "Abnormality of facial skeleton", "Abnormality of facial soft tissue", "Abnormality of female external genitalia", "Abnormality of femur morphology", "Abnormality of fibula morphology", "Abnormality of finger", "Abnormality of fluid regulation", "Abnormality of folate metabolism", "Abnormality of fontanelles", "Abnormality of foveal pigmentation", "Abnormality of frontal sinus", "Abnormality of frontalis muscle belly", "Abnormality of fundus pigmentation", "Abnormality of globe location", "Abnormality of globe size", "Abnormality of glycolipid metabolism", "Abnormality of hair growth", "Abnormality of hair pigmentation", "Abnormality of hair texture", "Abnormality of hand joint mobility", "Abnormality of head blood vessel", "Abnormality of hepatobiliary system physiology", "Abnormality of hindbrain morphology", "Abnormality of humoral immunity", "Abnormality of immune serum protein physiology", "Abnormality of iron homeostasis", "Abnormality of krebs cycle metabolism", "Abnormality of lens shape", "Abnormality of limb epiphysis morphology", "Abnormality of lipoprotein cholesterol concentration", "Abnormality of long bone morphology", "Abnormality of lower limb epiphysis morphology", "Abnormality of lower limb joint", "Abnormality of lower limb metaphyses", "Abnormality of lower lip", "Abnormality of lysosomal metabolism", "Abnormality of macular pigmentation", "Abnormality of malar bones", "Abnormality of male internal genitalia", "Abnormality of masticatory muscle", "Abnormality of metacarpal epiphyses", "Abnormality of metacarpophalangeal joint", "Abnormality of mouth shape", "Abnormality of mouth size", "Abnormality of muscle size", "Abnormality of nail color", "Abnormality of neuronal migration", "Abnormality of neutrophil morphology", "Abnormality of neutrophil physiology", "Abnormality of neutrophils", "Abnormality of ocular smooth pursuit", "Abnormality of pain sensation", "Abnormality of pancreas physiology", "Abnormality of pelvic girdle bone morphology", "Abnormality of periauricular region", "Abnormality of peripheral nerves", "Abnormality of prenatal development or birth", "Abnormality of primary teeth", "Abnormality of prothrombin", "Abnormality of pulmonary circulation", "Abnormality of refraction", "Abnormality of renal excretion", "Abnormality of renin angiotensin system", "Abnormality of reproductive system physiology", "Abnormality of retinal pigmentation", "Abnormality of salivation", "Abnormality of secondary sexual hair", "Abnormality of skeletal maturation", "Abnormality of skeletal muscle fiber size", "Abnormality of skin adnexa physiology", "Abnormality of skin physiology", "Abnormality of skin pigmentation", "Abnormality of skull ossification", "Abnormality of small intestinal villus morphology", "Abnormality of somatosensory evoked potentials", "Abnormality of subcutaneous fat tissue", "Abnormality of t cell physiology", "Abnormality of taste sensation", "Abnormality of temperature regulation", "Abnormality of thalamus morphology", "Abnormality of the 1st metacarpal", "Abnormality of the 2nd toe", "Abnormality of the 3rd toe", "Abnormality of the 4th metacarpal", "Abnormality of the 5th metacarpal", "Abnormality of the 5th toe", "Abnormality of the abdominal organs", "Abnormality of the abdominal wall", "Abnormality of the achilles tendon", "Abnormality of the adrenal glands", "Abnormality of the alveolar ridges", "Abnormality of the amniotic fluid", "Abnormality of the ankles", "Abnormality of the anterior fontanelle", "Abnormality of the antihelix", "Abnormality of the antitragus", "Abnormality of the anus", "Abnormality of the auditory canal", "Abnormality of the autonomic nervous system", "Abnormality of the axillary hair", "Abnormality of the basal ganglia", "Abnormality of the biliary system", "Abnormality of the bladder", "Abnormality of the brainstem white matter", "Abnormality of the breast", "Abnormality of the calcaneus", "Abnormality of the calf", "Abnormality of the calf musculature", "Abnormality of the calvaria", "Abnormality of the carpal bones", "Abnormality of the cerebral subcortex", "Abnormality of the cerebrospinal fluid", "Abnormality of the cervical spine", "Abnormality of the cheek", "Abnormality of the chin", "Abnormality of the choanae", "Abnormality of the clitoris", "Abnormality of the coagulation cascade", "Abnormality of the columella", "Abnormality of the common coagulation pathway", "Abnormality of the costochondral junction", "Abnormality of the crus of the helix", "Abnormality of the curvature of the cornea", "Abnormality of the curvature of the vertebral column", "Abnormality of the dentition", "Abnormality of the diaphragm", "Abnormality of the diencephalon", "Abnormality of the distal phalanges of the toes", "Abnormality of the distal phalanx of the hallux", "Abnormality of the distal phalanx of the thumb", "Abnormality of the dorsal column of the spinal cord", "Abnormality of the elbow", "Abnormality of the endometrium", "Abnormality of the epididymis", "Abnormality of the epiphyses of the distal phalanx of finger", "Abnormality of the eustachian tube", "Abnormality of the external nose", "Abnormality of the extraocular muscles", "Abnormality of the extrinsic pathway", "Abnormality of the female genitalia", "Abnormality of the fetal cardiovascular system", "Abnormality of the fifth metatarsal bone", "Abnormality of the first metatarsal bone", "Abnormality of the fontanelles or cranial sutures", "Abnormality of the foot musculature", "Abnormality of the forearm", "Abnormality of the forehead", "Abnormality of the frontal hairline", "Abnormality of the gallbladder", "Abnormality of the gastric mucosa", "Abnormality of the gingiva", "Abnormality of the glabella", "Abnormality of the glenoid fossa", "Abnormality of the hairline", "Abnormality of the hallux", "Abnormality of the helix", "Abnormality of the hepatic vasculature", "Abnormality of the humeroradial joint", "Abnormality of the humerus", "Abnormality of the hypothalamus pituitary axis", "Abnormality of the hypothenar eminence", "Abnormality of the incisor", "Abnormality of the inner ear", "Abnormality of the internal auditory canal", "Abnormality of the intervertebral disk", "Abnormality of the intrahepatic bile duct", "Abnormality of the intrinsic pathway", "Abnormality of the ischium", "Abnormality of the kidney", "Abnormality of the knee", "Abnormality of the larynx", "Abnormality of the lens", "Abnormality of the leydig cells", "Abnormality of the liver", "Abnormality of the lower urinary tract", "Abnormality of the lymph nodes", "Abnormality of the lymphatic system", "Abnormality of the mastoid", "Abnormality of the maxilla", "Abnormality of the menstrual cycle", "Abnormality of the metacarpal bones", "Abnormality of the metaphysis", "Abnormality of the metopic suture", "Abnormality of the middle ear", "Abnormality of the middle ear ossicles", "Abnormality of the middle phalanges of the toes", "Abnormality of the middle phalanx of the 5th finger", "Abnormality of the midface", "Abnormality of the mitochondrion", "Abnormality of the musculature of the hand", "Abnormality of the musculature of the limbs", "Abnormality of the musculature of the lower limbs", "Abnormality of the musculature of the thigh", "Abnormality of the musculature of the upper arm", "Abnormality of the musculature of the upper limbs", "Abnormality of the nail", "Abnormality of the nasal alae", "Abnormality of the nasal bone", "Abnormality of the nasal cavity", "Abnormality of the nasal dorsum", "Abnormality of the nasal septum", "Abnormality of the nasal skeleton", "Abnormality of the nasal tip", "Abnormality of the nasolabial region", "Abnormality of the neck", "Abnormality of the odontoid process", "Abnormality of the optic nerve", "Abnormality of the outer ear", "Abnormality of the ovary", "Abnormality of the palm", "Abnormality of the palpebral fissures", "Abnormality of the pancreas", "Abnormality of the parathyroid gland", "Abnormality of the parathyroid morphology", "Abnormality of the periorbital region", "Abnormality of the peripheral nervous system", "Abnormality of the peritoneum", "Abnormality of the periungual region", "Abnormality of the phalanges of the hallux", "Abnormality of the phalanges of the toes", "Abnormality of the pharynx", "Abnormality of the philtrum", "Abnormality of the pineal gland", "Abnormality of the pinna", "Abnormality of the pituitary gland", "Abnormality of the plantar skin of foot", "Abnormality of the posterior pituitary", "Abnormality of the protein c anticoagulant pathway", "Abnormality of the proximal phalanx of the thumb", "Abnormality of the pubic bone", "Abnormality of the pubic hair", "Abnormality of the pulmonary artery", "Abnormality of the pulmonary vasculature", "Abnormality of the pulmonary veins", "Abnormality of the pylorus", "Abnormality of the radial head", "Abnormality of the radioulnar joints", "Abnormality of the ribs", "Abnormality of the scrotum", "Abnormality of the sense of smell", "Abnormality of the septum pellucidum", "Abnormality of the shoulder girdle musculature", "Abnormality of the skull base", "Abnormality of the small intestine", "Abnormality of the spinal cord", "Abnormality of the spinocerebellar tracts", "Abnormality of the spleen", "Abnormality of the stapes", "Abnormality of the subungual region", "Abnormality of the supraorbital ridges", "Abnormality of the synovia", "Abnormality of the tarsal bones", "Abnormality of the temporomandibular joint", "Abnormality of the testis size", "Abnormality of the thenar eminence", "Abnormality of the thoracic cavity", "Abnormality of the thymus", "Abnormality of the thyroid gland", "Abnormality of the tongue", "Abnormality of the tonsils", "Abnormality of the tragus", "Abnormality of the ulna", "Abnormality of the umbilical cord", "Abnormality of the upper arm", "Abnormality of the upper respiratory tract", "Abnormality of the ureter", "Abnormality of the urethra", "Abnormality of the urinary system physiology", "Abnormality of the uterus", "Abnormality of the vasculature of the eye", "Abnormality of the vertebral endplates", "Abnormality of the vestibulocochlear nerve", "Abnormality of the voice", "Abnormality of the wrist", "Abnormality of the zygomatic bone", "Abnormality of thyroid physiology", "Abnormality of tibia morphology", "Abnormality of toe", "Abnormality of tumor necrosis factor secretion", "Abnormality of ulnar metaphysis", "Abnormality of upper limb epiphysis morphology", "Abnormality of upper limb joint", "Abnormality of upper limb metaphysis", "Abnormality of upper lip", "Abnormality of upper lip vermillion", "Abnormality of urinary uric acid concentration", "Abnormality of urine calcium concentration", "Abnormality of urine catecholamine concentration", "Abnormality of urine homeostasis", "Abnormality of visual evoked potentials", "Abnormality of vitamin a metabolism", "Abnormality of vitamin b metabolism", "Abnormality of vitamin b12 metabolism", "Abnormality of vitamin d metabolism", "Abnormality of vitamin e metabolism", "Abnormality of vitamin k metabolism", "Abnormality of vitamin metabolism", "Abnormality on pulmonary function testing", "Abnormally folded helix", "Abnormally large globe", "Abnormally lax or hyperextensible skin", "Abnormally low pitched voice", "Abnormally ossified vertebrae", "Abnormally shaped carpal bones", "Abscess", "Absence of pubertal development", "Absence of secondary sex characteristics", "Absence of subcutaneous fat", "Absence of the sacrum", "Absent axillary hair", "Absent brainstem auditory responses", "Absent distal phalanges", "Absent earlobe", "Absent epiphyses", "Absent eyebrow", "Absent facial hair", "Absent fingernail", "Absent forearm bone", "Absent foveal reflex", "Absent frontal sinuses", "Absent hair", "Absent hand", "Absent hypoplastic paranasal sinuses", "Absent nares", "Absent nipple", "Absent or minimally ossified vertebral bodies", "Absent outer dynein arms", "Absent palmar crease", "Absent septum pellucidum", "Absent shortened dynein arms", "Absent speech", "Absent sternal ossification", "Absent testis", "Absent thumb", "Absent thumbnail", "Absent tibia", "Absent toe", "Absent toenail", "Acanthocytosis", "Acantholysis", "Acanthosis nigricans", "Accelerated atherosclerosis", "Accelerated skeletal maturation", "Accessory oral frenulum", "Accessory spleen", "Acetabular dysplasia", "Acetabular spurs", "Achilles tendon contracture", "Achromatopsia", "Acidemia", "Acne", "Acne inversa", "Acquired abnormal hair pattern", "Acral blistering", "Acral ulceration", "Acromesomelia", "Acroparesthesia", "Action tremor", "Acute coronary syndrome", "Acute encephalopathy", "Acute hepatic failure", "Acute kidney injury", "Acute leukemia", "Acute lymphoblastic leukemia", "Acute myeloid leukemia", "Acute pancreatitis", "Acute phase response", "Addictive behavior", "Adducted thumb", "Adenocarcinoma of the colon", "Adenocarcinoma of the intestines", "Adenocarcinoma of the small intestine", "Adenoma sebaceum", "Adenomatous colonic polyposis", "Adipose tissue loss", "Adrenal hyperplasia", "Adrenal hypoplasia", "Adrenal insufficiency", "Adrenal overactivity", "Adrenocortical abnormality", "Adrenocortical carcinoma", "Adrenocorticotropic hormone deficiency", "Adrenocorticotropic hormone excess", "Adrenocorticotropin deficient adrenal insufficiency", "Adult onset", "Advanced eruption of teeth", "Advanced ossification of carpal bones", "Agammaglobulinemia", "Aganglionic megacolon", "Agenesis of central incisor", "Agenesis of cerebellar vermis", "Agenesis of corpus callosum", "Agenesis of incisor", "Agenesis of lateral incisor", "Agenesis of maxillary incisor", "Agenesis of permanent teeth", "Aggressive behavior", "Agitation", "Agnosia", "Agyria", "Airway obstruction", "Akinesia", "Alacrima", "Albinism", "Albuminuria", "Alexia", "Alkalosis", "Allergic rhinitis", "Allergy", "Alopecia", "Alopecia of scalp", "Alopecia totalis", "Alopecia universalis", "Alternating esotropia", "Alveolar cell carcinoma", "Alveolar rhabdomyosarcoma", "Alveolar ridge overgrowth", "Alzheimer disease", "Amaurosis fugax", "Ambiguous genitalia", "Ambiguous genitalia female", "Ambiguous genitalia male", "Amblyopia", "Amegakaryocytic thrombocytopenia", "Amelogenesis imperfecta", "Amenorrhea", "Aminoaciduria", "Amniotic constriction ring", "Amyloidosis", "Amyotrophic lateral sclerosis", "Anal atresia", "Anal stenosis", "Anarthria", "Anasarca", "Anemia of inadequate production", "Anemic pallor", "Anencephaly", "Angina pectoris", "Angioedema", "Angiofibromas", "Angioid streaks of the fundus", "Angiokeratoma", "Angular cheilitis", "Anhidrosis", "Aniridia", "Anisocoria", "Anisocytosis", "Anisopoikilocytosis", "Anisospondyly", "Ankle clonus", "Ankle flexion contracture", "Ankle weakness", "Ankyloblepharon", "Ankyloglossia", "Ankylosis", "Annular pancreas", "Anodontia", "Anomalous trichromacy", "Anomic aphasia", "Anonychia", "Anophthalmia", "Anorectal anomaly", "Anorexia", "Anosmia", "Anotia", "Antenatal onset", "Anterior chamber synechiae", "Anterior open bite malocclusion", "Anterior pituitary dysgenesis", "Anterior plagiocephaly", "Anterior rib cupping", "Anterior synechiae of the anterior chamber", "Anterior uveitis", "Anteriorly placed anus", "Anteverted ears", "Anti thyroid peroxidase antibody positivity", "Antineutrophil antibody positivity", "Antinuclear antibody positivity", "Antiphospholipid antibody positivity", "Aortic aneurysm", "Aortic arch aneurysm", "Aortic atherosclerotic lesion", "Aortic dissection", "Aortic regurgitation", "Aortic root aneurysm", "Aortic valve calcification", "Aortic valve stenosis", "Aphasia", "Aphthous ulcer", "Aplasia cutis congenita", "Aplasia cutis congenita of scalp", "Aplasia cutis congenita on trunk or limbs", "Aplasia cutis congenita over the scalp vertex", "Aplasia hypoplasia affecting bones of the axial skeleton", "Aplasia hypoplasia affecting the anterior segment of the eye", "Aplasia hypoplasia affecting the eye", "Aplasia hypoplasia affecting the fundus", "Aplasia hypoplasia involving bones of the feet", "Aplasia hypoplasia involving bones of the lower limbs", "Aplasia hypoplasia involving bones of the thorax", "Aplasia hypoplasia involving bones of the upper limbs", "Aplasia hypoplasia involving forearm bones", "Aplasia hypoplasia involving the carpal bones", "Aplasia hypoplasia involving the femoral head and neck", "Aplasia hypoplasia involving the metacarpal bones", "Aplasia hypoplasia involving the musculature of the upper limbs", "Aplasia hypoplasia involving the nose", "Aplasia hypoplasia involving the pelvis", "Aplasia hypoplasia involving the sinuses", "Aplasia hypoplasia involving the skeletal musculature", "Aplasia hypoplasia involving the skeleton", "Aplasia hypoplasia involving the vertebral column", "Aplasia hypoplasia of fingers", "Aplasia hypoplasia of metatarsal bones", "Aplasia hypoplasia of the 4th metacarpal", "Aplasia hypoplasia of the 5th finger", "Aplasia hypoplasia of the 5th metacarpal", "Aplasia hypoplasia of the abdominal wall musculature", "Aplasia hypoplasia of the bladder", "Aplasia hypoplasia of the breasts", "Aplasia hypoplasia of the capital femoral epiphysis", "Aplasia hypoplasia of the cerebellar vermis", "Aplasia hypoplasia of the cerebellum", "Aplasia hypoplasia of the cerebral white matter", "Aplasia hypoplasia of the clavicles", "Aplasia hypoplasia of the colon", "Aplasia hypoplasia of the distal phalanges of the hand", "Aplasia hypoplasia of the distal phalanx of the thumb", "Aplasia hypoplasia of the ear", "Aplasia hypoplasia of the earlobes", "Aplasia hypoplasia of the epiglottis", "Aplasia hypoplasia of the extremities", "Aplasia hypoplasia of the eyebrow", "Aplasia hypoplasia of the eyelid", "Aplasia hypoplasia of the femur", "Aplasia hypoplasia of the fibula", "Aplasia hypoplasia of the gallbladder", "Aplasia hypoplasia of the hallux", "Aplasia hypoplasia of the humerus", "Aplasia hypoplasia of the lungs", "Aplasia hypoplasia of the middle phalanges of the toes", "Aplasia hypoplasia of the nails", "Aplasia hypoplasia of the nasal bone", "Aplasia hypoplasia of the nasal septum", "Aplasia hypoplasia of the nipples", "Aplasia hypoplasia of the optic nerve", "Aplasia hypoplasia of the ovary", "Aplasia hypoplasia of the palmar creases", "Aplasia hypoplasia of the patella", "Aplasia hypoplasia of the phalanges of the hand", "Aplasia hypoplasia of the phalanges of the thumb", "Aplasia hypoplasia of the phalanges of the toes", "Aplasia hypoplasia of the proximal phalanges of the hand", "Aplasia hypoplasia of the pubic bone", "Aplasia hypoplasia of the radius", "Aplasia hypoplasia of the retina", "Aplasia hypoplasia of the ribs", "Aplasia hypoplasia of the sacrum", "Aplasia hypoplasia of the scapulae", "Aplasia hypoplasia of the skin", "Aplasia hypoplasia of the spleen", "Aplasia hypoplasia of the sternum", "Aplasia hypoplasia of the thumb", "Aplasia hypoplasia of the thymus", "Aplasia hypoplasia of the thyroid gland", "Aplasia hypoplasia of the tibia", "Aplasia hypoplasia of the tongue", "Aplasia hypoplasia of the tragus", "Aplasia hypoplasia of the ulna", "Aplasia hypoplasia of the uterus", "Aplasia hypoplasia of the uvula", "Aplasia hypoplasia of the vagina", "Aplasia hypoplasia of toe", "Aplasia involving bones of the extremities", "Aplasia involving bones of the lower limbs", "Aplasia of metacarpal bones", "Aplasia of the fingers", "Aplasia of the middle phalanx of the hand", "Aplasia of the phalanges of the hand", "Aplasia of the phalanges of the toes", "Aplasia of the proximal phalanges of the hand", "Aplasia of the semicircular canal", "Aplasia of the uterus", "Aplastic anemia", "Aplastic clavicle", "Aplastic hypoplastic lacrimal glands", "Aplastic hypoplastic toenail", "Apnea", "Apneic episodes in infancy", "Apneic episodes precipitated by illness fatigue stress", "Appendicular hypotonia", "Apraxia", "Aqueductal stenosis", "Arachnodactyly", "Arachnoid hemangiomatosis", "Areflexia", "Areflexia of lower limbs", "Arm dystonia", "Arnold chiari malformation", "Arnold chiari type i malformation", "Arrhinencephaly", "Arteria lusoria", "Arterial dissection", "Arterial rupture", "Arterial stenosis", "Arterial thrombosis", "Arteriosclerosis", "Arteriovenous malformation", "Arthralgia", "Arthritis", "Arthrogryposis multiplex congenita", "Arthropathy", "Ascending aortic dissection", "Ascending tubular aorta aneurysm", "Ascites", "Aspiration", "Aspiration pneumonia", "Asterixis", "Asthenia", "Asthma", "Astigmatism", "Astrocytoma", "Astrocytosis", "Asymmetric growth", "Asymmetric septal hypertrophy", "Asymmetry of spinal facet joints", "Asymmetry of the ears", "Asymmetry of the thorax", "Atelectasis", "Athetosis", "Atlantoaxial abnormality", "Atlantoaxial dislocation", "Atlantoaxial instability", "Atonic seizure", "Atopic dermatitis", "Atresia of the external auditory canal", "Atrial arrhythmia", "Atrial flutter", "Atrioventricular canal defect", "Atrophic scars", "Atrophy degeneration affecting the brainstem", "Atrophy degeneration affecting the central nervous system", "Atrophy degeneration affecting the cerebrum", "Atrophy degeneration involving the caudate nucleus", "Atrophy degeneration involving the corticospinal tracts", "Atrophy degeneration involving the spinal cord", "Atrophy of alveolar ridges", "Attention deficit hyperactivity disorder", "Attenuation of retinal blood vessels", "Atypical absence seizure", "Auditory hallucinations", "Autism", "Autistic behavior", "Autoamputation", "Autoamputation of digits", "Autoimmune antibody positivity", "Autoimmune hemolytic anemia", "Autoimmune thrombocytopenia", "Autoimmunity", "Autophagic vacuoles", "Autosomal dominant germline de novo mutation", "Avascular necrosis", "Avascular necrosis of the capital femoral epiphysis", "Axial dystonia", "Axial muscle weakness", "Axillary pterygium", "Axonal degeneration", "Axonal degeneration regeneration", "Axonal loss", "Axonal regeneration", "Azoospermia", "B cell lymphoma", "B lymphocytopenia", "Babinski sign", "Back pain", "Bacterial endocarditis", "Barrel shaped chest", "Barrett esophagus", "Basal cell carcinoma", "Basal ganglia calcification", "Basal ganglia cysts", "Basal ganglia gliosis", "Basilar impression", "Basilar invagination", "Beaded ribs", "Beaking of vertebral bodies", "Bell shaped thorax", "Benign neoplasm of the central nervous system", "Bicarbonaturia", "Biconcave vertebral bodies", "Bicornuate uterus", "Bifid epiglottis", "Bifid nasal tip", "Bifid nose", "Bifid ribs", "Bifid scrotum", "Bifid tongue", "Bifid uterus", "Bifid uvula", "Bilateral camptodactyly", "Bilateral cleft lip", "Bilateral cleft lip and palate", "Bilateral cleft palate", "Bilateral coxa valga", "Bilateral cryptorchidism", "Bilateral external ear deformity", "Bilateral microphthalmos", "Bilateral polymicrogyria", "Bilateral ptosis", "Bilateral sensorineural hearing impairment", "Bilateral single transverse palmar creases", "Bilateral talipes equinovarus", "Bilateral tonic clonic seizure", "Bilateral tonic clonic seizure with focal onset", "Bilateral tonic clonic seizure with generalized onset", "Bile duct proliferation", "Biliary atresia", "Biliary cirrhosis", "Biliary tract abnormality", "Biliary tract neoplasm", "Bimanual synkinesia", "Biparietal narrowing", "Bird like facies", "Birth length greater than 97th percentile", "Birth length less than 3rd percentile", "Biventricular hypertrophy", "Bladder diverticulum", "Bladder neoplasm", "Blepharitis", "Blepharophimosis", "Blindness", "Blistering by anatomical location", "Blistering by histological location", "Bloodstream infectious agent", "Bloody diarrhea", "Blue irides", "Blue nevus", "Blue sclerae", "Blurred vision", "Bone cyst", "Bone fracture", "Bone marrow foam cells", "Bone marrow hypercellularity", "Bone marrow hypocellularity", "Bone pain", "Bone spicule pigmentation of the retina", "Bowel diverticulosis", "Bowing of the arm", "Bowing of the legs", "Brachycephaly", "Brachydactyly", "Brachyturricephaly", "Bradycardia", "Bradykinesia", "Brain imaging abnormality", "Brain neoplasm", "Brain stem compression", "Branchial anomaly", "Branchial cyst", "Branchial fistula", "Breast aplasia", "Breast carcinoma", "Breast hypoplasia", "Breathing dysregulation", "Breech presentation", "Brisk reflexes", "Brittle hair", "Broad alveolar ridges", "Broad based gait", "Broad chin", "Broad clavicles", "Broad columella", "Broad distal phalanx of finger", "Broad eyebrow", "Broad face", "Broad femoral neck", "Broad finger", "Broad foot", "Broad forehead", "Broad hallux phalanx", "Broad jaw", "Broad long bones", "Broad metacarpals", "Broad metatarsal", "Broad nail", "Broad nasal tip", "Broad neck", "Broad palm", "Broad phalanx of the toes", "Broad philtrum", "Broad ribs", "Broad thumb", "Broad toe", "Bronchiectasis", "Bronchitis", "Bronchomalacia", "Bronchospasm", "Bruising susceptibility", "Brushfield spots", "Bruxism", "Bulbar palsy", "Bulbar signs", "Bulbous nose", "Bull s eye maculopathy", "Bundle branch block", "Buphthalmos", "Burkitt lymphoma", "Butterfly vertebrae", "Cachexia", "Caesarian section", "Cafe au lait spot", "Calcific stippling", "Calcification of the aorta", "Calcinosis", "Calcium nephrolithiasis", "Calcium oxalate nephrolithiasis", "Calvarial hyperostosis", "Calvarial osteosclerosis", "Calvarial skull defect", "Camptodactyly of toe", "Capillary hemangioma", "Capillary malformation", "Capitate hamate fusion", "Carcinoid tumor", "Carcinoma", "Cardiac arrest", "Cardiac conduction abnormality", "Cardiac diverticulum", "Cardiac shunt", "Cardiac valve calcification", "Cardiomegaly", "Cardiorespiratory arrest", "Cardiovascular calcification", "Carious teeth", "Carpal bone hypoplasia", "Carpal synostosis", "Cataplexy", "Caudate atrophy", "Cavernous hemangioma", "Cavum septum pellucidum", "Celiac disease", "Cellular immunodeficiency", "Cellulitis", "Central adrenal insufficiency", "Central apnea", "Central diabetes insipidus", "Central heterochromia", "Central hypothyroidism", "Central hypoventilation", "Central nervous system cyst", "Central opacification of the cornea", "Central primitive neuroectodermal tumor", "Central scotoma", "Central sleep apnea", "Centrally nucleated skeletal muscle fibers", "Centrocecal scotoma", "Cerebellar atrophy", "Cerebellar cortical atrophy", "Cerebellar cyst", "Cerebellar dysplasia", "Cerebellar hemorrhage", "Cerebellar hypoplasia", "Cerebellar malformation", "Cerebellar vermis atrophy", "Cerebral amyloid angiopathy", "Cerebral calcification", "Cerebral cortical atrophy", "Cerebral dysmyelination", "Cerebral edema", "Cerebral hamartoma", "Cerebral hemorrhage", "Cerebral hypomyelination", "Cerebral hypoplasia", "Cerebral inclusion bodies", "Cerebral palsy", "Cerebral venous thrombosis", "Cerebral visual impairment", "Cerebral white matter atrophy", "Cerebral white matter hypoplasia", "Cervical kyphosis", "Cervical myelopathy", "Cervical ribs", "Cervical spinal canal stenosis", "Cervical spine instability", "Cervical subluxation", "Cessation of head growth", "Cheilitis", "Cherry red spot of the macula", "Chest pain", "Chilblains", "Childhood onset", "Childhood onset sensorineural hearing impairment", "Childhood onset truncal obesity", "Chills", "Choanal stenosis", "Choking episodes", "Cholangiocarcinoma", "Cholangitis", "Cholecystitis", "Cholestasis", "Cholestatic liver disease", "Chondrocalcinosis", "Chondrosarcoma", "Chordee", "Chorea", "Choreoathetosis", "Choriocarcinoma", "Chorioretinal atrophy", "Chorioretinal coloboma", "Chorioretinal degeneration", "Chorioretinal dysplasia", "Chorioretinal dystrophy", "Chorioretinal hypopigmentation", "Choroid plexus carcinoma", "Choroid plexus cyst", "Choroidal melanoma", "Choroidal neovascularization", "Chromosomal breakage induced by crosslinking agents", "Chromosomal breakage induced by ionizing radiation", "Chromosome breakage", "Chronic atrophic gastritis", "Chronic axonal neuropathy", "Chronic bronchitis", "Chronic constipation", "Chronic diarrhea", "Chronic fatigue", "Chronic hemolytic anemia", "Chronic hepatic failure", "Chronic infection", "Chronic kidney disease", "Chronic leukemia", "Chronic lung disease", "Chronic lymphatic leukemia", "Chronic mucocutaneous candidiasis", "Chronic myelogenous leukemia", "Chronic neutropenia", "Chronic noninfectious lymphadenopathy", "Chronic oral candidiasis", "Chronic otitis media", "Chronic pulmonary obstruction", "Chronic rhinitis", "Chronic sinusitis", "Chylothorax", "Cigarette paper scars", "Cirrhosis", "Cleft hard palate", "Cleft lip", "Cleft soft palate", "Cleft upper lip", "Clinodactyly", "Clitoral hypoplasia", "Clonic seizure", "Clonus", "Cloverleaf skull", "Clubbing", "Clubbing of fingers", "Clubbing of toes", "Clumsiness", "Cns demyelination", "Cns hypomyelination", "Coarctation of aorta", "Coarse facial features", "Coarse hair", "Cochlear malformation", "Cognitive impairment", "Cogwheel rigidity", "Cold induced muscle cramps", "Colitis", "Collectionism", "Coloboma", "Colon cancer", "Color vision defect", "Color vision test abnormality", "Colorectal polyposis", "Colpocephaly", "Coma", "Combined immunodeficiency", "Communicating hydrocephalus", "Compensatory head posture", "Complete atrioventricular canal defect", "Complete duplication of phalanx of hand", "Complex febrile seizure", "Concave nail", "Concave nasal ridge", "Concentric hypertrophic cardiomyopathy", "Cone cone rod dystrophy", "Cone shaped epiphyses of the phalanges of the hand", "Cone shaped epiphysis", "Confetti like hypopigmented macules", "Confusion", "Congenital adrenal hyperplasia", "Congenital bilateral hip dislocation", "Congenital blindness", "Congenital contracture", "Congenital craniofacial dysostosis", "Congenital diaphragmatic hernia", "Congenital finger flexion contractures", "Congenital hemolytic anemia", "Congenital hepatic fibrosis", "Congenital hip dislocation", "Congenital hypothyroidism", "Congenital ichthyosiform erythroderma", "Congenital localized absence of skin", "Congenital malformation of the great arteries", "Congenital malformation of the left heart", "Congenital malformation of the right heart", "Congenital muscular dystrophy", "Congenital muscular torticollis", "Congenital nonbullous ichthyosiform erythroderma", "Congenital nystagmus", "Congenital onset", "Congenital posterior urethral valve", "Congenital ptosis", "Congenital sensorineural hearing impairment", "Congenital stationary night blindness", "Congenital thrombocytopenia", "Congestive heart failure", "Conical incisor", "Conical tooth", "Conjugated hyperbilirubinemia", "Conjunctival hamartoma", "Connective tissue nevi", "Conspicuously happy disposition", "Constipation", "Constitutional symptom", "Constriction of peripheral visual field", "Contiguous gene syndrome", "Contractures involving the joints of the feet", "Contractures of the joints of the lower limbs", "Contractures of the joints of the upper limbs", "Contractures of the large joints", "Convex nasal ridge", "Coombs positive hemolytic anemia", "Cor pulmonale", "Corneal dystrophy", "Corneal erosion", "Corneal neovascularization", "Corneal opacity", "Corneal scarring", "Corneal ulceration", "Coronal cleft vertebrae", "Coronal craniosynostosis", "Coronary artery aneurysm", "Coronary artery atherosclerosis", "Corpus callosum atrophy", "Cortical cataract", "Cortical dysplasia", "Cortical myoclonus", "Cortical thickening of long bone diaphyses", "Corticospinal tract hypoplasia", "Cough", "Coxa valga", "Coxa vara", "Crackles", "Cranial asymmetry", "Cranial hyperostosis", "Cranial nerve compression", "Craniofacial asymmetry", "Craniofacial dysostosis", "Craniofacial hyperostosis", "Craniofacial osteosclerosis", "Craniosynostosis", "Crumpled long bones", "Cryptorchidism", "Csf lymphocytic pleiocytosis", "Csf pleocytosis", "Cubitus valgus", "Cupped ear", "Cupped ribs", "Curly eyelashes", "Curly hair", "Cutaneous abscess", "Cutaneous amyloidosis", "Cutaneous cyst", "Cutaneous finger syndactyly", "Cutaneous melanoma", "Cutaneous photosensitivity", "Cutaneous syndactyly", "Cutaneous syndactyly of toes", "Cutis laxa", "Cutis marmorata", "Cyanosis", "Cyanotic episode", "Cyclopia", "Cystic hygroma", "Cystic liver disease", "Cystic renal dysplasia", "Cystinuria", "Cystoid macular edema", "Cytochrome c oxidase negative muscle fibers", "Dark urine", "Death in adolescence", "Death in adulthood", "Death in childhood", "Death in infancy", "Decerebrate rigidity", "Decreased absent ankle reflexes", "Decreased activity of mitochondrial complex i", "Decreased activity of mitochondrial complex ii", "Decreased activity of mitochondrial complex iii", "Decreased activity of mitochondrial complex iv", "Decreased activity of the pyruvate dehydrogenase complex", "Decreased adenosylcobalamin", "Decreased adipose tissue", "Decreased calvarial ossification", "Decreased cd4 cd8 ratio", "Decreased cervical spine flexion due to contractures of posterior cervical muscles", "Decreased circulating acth level", "Decreased circulating aldosterone level", "Decreased circulating androgen concentration", "Decreased circulating antibody level", "Decreased circulating copper concentration", "Decreased circulating cortisol level", "Decreased circulating follicle stimulating hormone concentration", "Decreased circulating gaba concentration", "Decreased circulating gonadotropin concentration", "Decreased circulating iga level", "Decreased circulating igg level", "Decreased circulating igg subclass level", "Decreased circulating level of specific antibody", "Decreased circulating progesterone", "Decreased circulating total iga", "Decreased circulating total igg", "Decreased circulating total igm", "Decreased corneal reflex", "Decreased facial expression", "Decreased fertility", "Decreased fertility in females", "Decreased fertility in males", "Decreased head circumference", "Decreased lacrimation", "Decreased ldl cholesterol concentration", "Decreased libido", "Decreased light and dark adapted electroretinogram amplitude", "Decreased lymphocyte apoptosis", "Decreased lymphocyte proliferation in response to mitogen", "Decreased mean corpuscular volume", "Decreased methylcobalamin", "Decreased methylmalonyl coa mutase activity", "Decreased muscle mass", "Decreased number of large peripheral myelinated nerve fibers", "Decreased number of peripheral myelinated nerve fibers", "Decreased palmar creases", "Decreased patellar reflex", "Decreased plasma carnitine", "Decreased proportion of cd3 positive t cells", "Decreased proportion of cd4 positive helper t cells", "Decreased proportion of cd8 positive t cells", "Decreased pulmonary function", "Decreased serum complement c3", "Decreased serum insulin like growth factor 1", "Decreased serum iron", "Decreased size of nerve terminals", "Decreased specific anti polysaccharide antibody level", "Decreased specific antibody response to protein vaccine", "Decreased specific antibody response to vaccination", "Decreased specific pneumococcal antibody level", "Decreased testicular size", "Decreased urine output", "Deep palmar crease", "Deep philtrum", "Deep plantar creases", "Deep set nails", "Deep venous thrombosis", "Deeply set eye", "Defective dna repair after ultraviolet radiation damage", "Defective t cell proliferation", "Deformed rib cage", "Deformed sella turcica", "Deformed tarsal bones", "Degeneration of the lateral corticospinal tracts", "Degeneration of the striatum", "Dehydration", "Delayed ability to roll over", "Delayed ability to sit", "Delayed ability to stand", "Delayed ability to walk", "Delayed closure of the anterior fontanelle", "Delayed cns myelination", "Delayed cranial suture closure", "Delayed epiphyseal ossification", "Delayed eruption of permanent teeth", "Delayed eruption of primary teeth", "Delayed eruption of teeth", "Delayed fine motor development", "Delayed gross motor development", "Delayed menarche", "Delayed myelination", "Delayed ossification of carpal bones", "Delayed proximal femoral epiphyseal ossification", "Delayed puberty", "Delayed social development", "Delirium", "Delusions", "Dementia", "Demyelinating peripheral neuropathy", "Dental crowding", "Dental malocclusion", "Depletion of mitochondrial dna in muscle tissue", "Deposits immunoreactive to beta amyloid protein", "Depressed nasal bridge", "Depressed nasal ridge", "Depressed nasal tip", "Depression", "Dermal atrophy", "Dermal translucency", "Dermatological manifestations of systemic disorders", "Dermoid cyst", "Descending aortic dissection", "Desquamation of skin soon after birth", "Developmental cataract", "Developmental glaucoma", "Developmental regression", "Developmental stagnation", "Deviated nasal septum", "Deviation of the 2nd finger", "Deviation of the 3rd finger", "Deviation of the hallux", "Deviation of the hand or of fingers of the hand", "Deviation of the thumb", "Deviation of toes", "Diabetes insipidus", "Dialeptic seizure", "Diaphragmatic eventration", "Diaphragmatic paralysis", "Diaphragmatic weakness", "Diaphyseal sclerosis", "Diaphyseal thickening", "Diarrhea", "Diastasis recti", "Diastema", "Dicarboxylic aciduria", "Difficulty climbing stairs", "Difficulty in tongue movements", "Difficulty running", "Difficulty standing", "Difficulty walking", "Diffuse alveolar hemorrhage", "Diffuse cerebellar atrophy", "Diffuse cerebral atrophy", "Diffuse mesangial sclerosis", "Diffuse optic disc pallor", "Diffuse white matter abnormalities", "Digenic inheritance", "Digital flexor tenosynovitis", "Dilatation of the cerebral artery", "Dilatation of the ventricular cavity", "Dilated cardiomyopathy", "Dilated fourth ventricle", "Dilated third ventricle", "Dilation of lateral ventricles", "Dilation of virchow robin spaces", "Diminished ability to concentrate", "Diminished motivation", "Diminished movement", "Dimple chin", "Diplopia", "Disinhibition", "Displacement of the urethral meatus", "Disproportionate short limb short stature", "Disproportionate short stature", "Disproportionate short trunk short stature", "Disproportionate tall stature", "Disseminated intravascular coagulation", "Distal amyotrophy", "Distal arthrogryposis", "Distal joint laxity", "Distal lower limb amyotrophy", "Distal lower limb muscle weakness", "Distal muscle weakness", "Distal peripheral sensory neuropathy", "Distal sensory impairment", "Distal sensory impairment of all modalities", "Distal sensory loss of all modalities", "Distal upper limb amyotrophy", "Distal upper limb muscle weakness", "Disturbance of facial expression", "Dolichocephaly", "Down sloping shoulders", "Downslanted palpebral fissures", "Downturned corners of mouth", "Drowsiness", "Drusen", "Dry hair", "Dry skin", "Dumbbell shaped long bone", "Duodenal adenocarcinoma", "Duodenal atresia", "Duodenal stenosis", "Duplicated collecting system", "Duplication involving bones of the feet", "Duplication of hand bones", "Duplication of phalanx of hallux", "Duplication of the distal phalanx of hand", "Duplication of the distal phalanx of the thumb", "Duplication of thumb phalanx", "Dysarthria", "Dyscalculia", "Dyschromatopsia", "Dysdiadochokinesis", "Dysesthesia", "Dysgammaglobulinemia", "Dysgenesis of the cerebellar vermis", "Dysgenesis of the hippocampus", "Dysgerminoma", "Dysgraphia", "Dyskinesia", "Dyslexia", "Dysmenorrhea", "Dysmetria", "Dysmetric saccades", "Dysostosis multiplex", "Dyspareunia", "Dysphagia", "Dysphasia", "Dysphonia", "Dysplasia of the femoral head", "Dysplastic corpus callosum", "Dyspnea", "Dystonia", "Dystrophic fingernails", "Dystrophic toenail", "Dysuria", "Ear pain", "Early onset absence seizures", "Early onset of sexual maturation", "Easy fatigability", "Ecchymosis", "Echolalia", "Eclabion", "Eclampsia", "Ectodermal dysplasia", "Ectopia lentis", "Ectopia pupillae", "Ectopic anus", "Ectopic calcification", "Ectopic kidney", "Ectrodactyly", "Ectropion", "Ectropion of lower eyelids", "Eczema", "Eczematoid dermatitis", "Edema of the dorsum of feet", "Edema of the dorsum of hands", "Eeg with abnormally slow frequencies", "Eeg with burst suppression", "Eeg with continuous slow activity", "Eeg with focal epileptiform discharges", "Eeg with focal sharp slow waves", "Eeg with focal sharp waves", "Eeg with focal spike waves", "Eeg with focal spikes", "Eeg with frontal epileptiform discharges", "Eeg with generalized sharp slow waves", "Eeg with generalized slow activity", "Eeg with irregular generalized spike and wave complexes", "Eeg with multifocal slow activity", "Eeg with polyspike wave complexes", "Eeg with spike wave complexes", "Elbow ankylosis", "Elbow flexion contracture", "Elevated alkaline phosphatase of bone origin", "Elevated calcitonin", "Elevated circulating alanine aminotransferase concentration", "Elevated circulating aspartate aminotransferase concentration", "Elevated circulating follicle stimulating hormone level", "Elevated circulating glutaric acid concentration", "Elevated circulating growth hormone concentration", "Elevated circulating long chain fatty acid concentration", "Elevated circulating parathyroid hormone level", "Elevated circulating thyroid stimulating hormone concentration", "Elevated creatine kinase after exercise", "Elevated diastolic blood pressure", "Elevated gamma glutamyltransferase level", "Elevated hemoglobin a1c", "Elevated hepatic transaminase", "Elevated lactate pyruvate ratio", "Elevated mean arterial pressure", "Elevated proportion of cd4 negative cd8 negative alpha beta regulatory t cells", "Elevated pulmonary artery pressure", "Elevated serum acid phosphatase", "Elevated systolic blood pressure", "Elevated tissue non specific alkaline phosphatase", "Elevated urinary carboxylic acid", "Elevated urinary delta aminolevulinic acid", "Elevated urinary dicarboxylic acid level", "Elevated urinary monocarboxylic acid level", "Elfin facies", "Elliptocytosis", "Elongated superior cerebellar peduncle", "Embryonal neoplasm", "Embryonal renal neoplasm", "Emg abnormality", "Emg axonal abnormality", "Emg chronic denervation signs", "Emg decremental response of compound muscle action potential to repetitive nerve stimulation", "Emg impaired neuromuscular transmission", "Emg myopathic abnormalities", "Emg myotonic discharges", "Emg neuropathic changes", "Emg slow motor conduction", "Emotional lability", "Emphysema", "Enamel hypoplasia", "Encephalocele", "Encephalopathy", "Enchondroma", "Endocardial fibroelastosis", "Endocardial fibrosis", "Endocarditis", "Enlarged cerebellum", "Enlarged cisterna magna", "Enlarged joints", "Enlarged kidney", "Enlarged metaphyses", "Enlarged ovaries", "Enlarged posterior fossa", "Enlarged thorax", "Enlarged tonsils", "Enlargement of the costochondral junction", "Enlargement of the wrists", "Enterocolitis", "Enthesitis", "Entropion", "Enuresis", "Ependymoma", "Epicanthus", "Epicanthus inversus", "Epidermal acanthosis", "Epidermal hyperkeratosis", "Epidermal nevus", "Epidermoid cyst", "Epigastric pain", "Epileptic aura", "Epileptic encephalopathy", "Epileptic spasm", "Epiphora", "Epiphyseal dysplasia", "Epiphyseal stippling", "Epiretinal membrane", "Episodic ataxia", "Episodic hyperhidrosis", "Episodic hypertension", "Episodic pain", "Episodic respiratory distress", "Episodic tachypnea", "Episodic vomiting", "Epispadias", "Epistaxis", "Equinovarus deformity", "Equinus calcaneus", "Erectile dysfunction", "Erlenmeyer flask deformity of the femurs", "Eruption failure", "Erysipelas", "Erythema", "Erythema nodosum", "Erythematous papule", "Erythematous plaque", "Erythrocyte inclusion bodies", "Erythroderma", "Erythroid hyperplasia", "Erythroid hypoplasia", "Esodeviation", "Esophageal atresia", "Esophageal carcinoma", "Esophageal neoplasm", "Esophageal stenosis", "Esophageal stricture", "Esophageal varix", "Esophagitis", "Ethylmalonic aciduria", "Eunuchoid habitus", "Euryblepharon", "Eversion of lateral third of lower eyelids", "Everted upper lip vermilion", "Exaggerated cupid s bow", "Exaggerated startle response", "Exanthem", "Excessive daytime somnolence", "Excessive salivation", "Excessive wrinkled skin", "Excessive wrinkling of palmar skin", "Exercise induced muscle cramps", "Exercise induced muscle fatigue", "Exercise induced muscle stiffness", "Exercise induced myalgia", "Exercise induced myoglobinuria", "Exercise induced rhabdomyolysis", "Exercise intolerance", "Exertional dyspnea", "Exodeviation", "Exostoses", "Expressive aphasia", "Expressive language delay", "External ear malformation", "External genital hypoplasia", "External ophthalmoplegia", "Extra axial cerebrospinal fluid accumulation", "Extrahepatic cholestasis", "Extramedullary hematopoiesis", "Extrapyramidal dyskinesia", "Extrapyramidal muscular rigidity", "Eyelid coloboma", "Eyelid myoclonus", "Facial asymmetry", "Facial capillary hemangioma", "Facial cleft", "Facial diplegia", "Facial edema", "Facial erythema", "Facial grimacing", "Facial hemangioma", "Facial hyperostosis", "Facial hypertrichosis", "Facial hypotonia", "Facial paralysis", "Facial shape deformation", "Facial telangiectasia", "Failure of eruption of permanent teeth", "Failure to thrive", "Failure to thrive in infancy", "Fair hair", "Falls", "Fasciculations", "Fasting hyperinsulinemia", "Fasting hypoglycemia", "Fat malabsorption", "Fatigable weakness of bulbar muscles", "Fatigable weakness of distal limb muscles", "Fatigable weakness of respiratory muscles", "Fatigable weakness of skeletal muscles", "Fatigable weakness of swallowing muscles", "Fatiguable weakness of proximal limb muscles", "Fatigue", "Fatty replacement of skeletal muscle", "Feeding difficulties", "Feeding difficulties in infancy", "Female external genitalia in individual with 46 xy karyotype", "Female hypogonadism", "Female infertility", "Female pseudohermaphroditism", "Female reproductive system neoplasm", "Female sexual dysfunction", "Femoral bowing", "Femoral hernia", "Fetal akinesia sequence", "Fetal distress", "Fetal onset", "Fetal polyuria", "Fetal ultrasound soft marker", "Fever", "Fibroadenoma of the breast", "Fibrosarcoma", "Fibrous tissue neoplasm", "Fibular aplasia", "Fibular hypoplasia", "Fine hair", "Finger agnosia", "Finger clinodactyly", "Finger swelling", "Finger syndactyly", "Fingernail dysplasia", "Fingerprint intracellular accumulation of autofluorescent lipopigment storage material", "First degree atrioventricular block", "First dorsal interossei muscle weakness", "Flank pain", "Flared iliac wing", "Flared metaphysis", "Flared nostrils", "Flaring of rib cage", "Flat acetabular roof", "Flat cornea", "Flat face", "Flat forehead", "Flat nasal alae", "Flat occiput", "Flattened epiphysis", "Flattened femoral epiphysis", "Flattened femoral head", "Flexion contracture of digit", "Flexion contracture of thumb", "Fluctuations in consciousness", "Flushing", "Foam cells", "Focal aware seizure", "Focal cortical dysplasia", "Focal cortical dysplasia type ii", "Focal dystonia", "Focal emotional seizure", "Focal impaired awareness seizure", "Focal motor seizure", "Focal motor status epilepticus", "Focal myoclonic seizure", "Focal non motor seizure", "Focal onset seizure", "Focal segmental glomerulosclerosis", "Focal sensory seizure", "Focal t2 hyperintense basal ganglia lesion", "Focal t2 hyperintense brainstem lesion", "Focal tonic seizure", "Focal white matter lesions", "Follicular hyperkeratosis", "Follicular hyperplasia", "Follicular thyroid carcinoma", "Food allergy", "Food intolerance", "Foot acroosteolysis", "Foot dorsiflexor weakness", "Foot oligodactyly", "Fractures of the long bones", "Fragile nails", "Fragile skin", "Fragmented epiphyses", "Freckling", "Frequent falls", "Frontal balding", "Frontal cortical atrophy", "Frontal hirsutism", "Frontal lobe dementia", "Frontotemporal cerebral atrophy", "Frontotemporal dementia", "Full cheeks", "Fulminant hepatic failure", "Functional abnormality of male internal genitalia", "Functional abnormality of the gastrointestinal tract", "Functional abnormality of the inner ear", "Functional abnormality of the middle ear", "Functional intestinal obstruction", "Functional motor deficit", "Furrowed tongue", "Fused cervical vertebrae", "Gait ataxia", "Gait disturbance", "Gait imbalance", "Galactorrhea", "Gangrene", "Gastric ulcer", "Gastritis", "Gastroesophageal reflux", "Gastrointestinal atresia", "Gastrointestinal carcinoma", "Gastrointestinal hemorrhage", "Gastrointestinal infarctions", "Gastrointestinal inflammation", "Gastrointestinal obstruction", "Gastrointestinal stroma tumor", "Gastroparesis", "Gastrostomy tube feeding in infancy", "Gaze evoked nystagmus", "Generalized abnormality of skin", "Generalized aminoaciduria", "Generalized amyotrophy", "Generalized clonic seizure", "Generalized dystonia", "Generalized edema", "Generalized hirsutism", "Generalized hyperkeratosis", "Generalized hyperpigmentation", "Generalized hyperreflexia", "Generalized hypertrichosis", "Generalized hypopigmentation", "Generalized hypopigmentation of hair", "Generalized hypotonia", "Generalized joint laxity", "Generalized limb muscle atrophy", "Generalized lipodystrophy", "Generalized lymphadenopathy", "Generalized muscle weakness", "Generalized myoclonic atonic seizure", "Generalized myoclonic seizure", "Generalized neonatal hypotonia", "Generalized onset motor seizure", "Generalized onset seizure", "Generalized osteoporosis", "Generalized osteosclerosis", "Generalized tonic seizure", "Genetic anticipation", "Genital neoplasm", "Genu recurvatum", "Genu valgum", "Genu varum", "Geographic atrophy", "Germ cell neoplasia", "Germinoma", "Giant platelets", "Gingival bleeding", "Gingival fibromatosis", "Gingival overgrowth", "Gingival recession", "Gingivitis", "Glaucoma", "Glioblastoma multiforme", "Glioma", "Gliosis", "Global brain atrophy", "Glomerular deposits", "Glomerular sclerosis", "Glomerulonephritis", "Glomerulopathy", "Glomus jugular tumor", "Glossitis", "Glossoptosis", "Glucose intolerance", "Glutaric aciduria", "Glycosuria", "Goiter", "Gonadal dysgenesis", "Gonadal neoplasm", "Gonadoblastoma", "Gonosomal inheritance", "Gout", "Gowers sign", "Grammar specific speech disorder", "Granulocytopenia", "Granulomatosis", "Gray matter heterotopia", "Gynecomastia", "Hallucinations", "Hallux valgus", "Hamartoma", "Hamartoma of the eye", "Hamartoma of tongue", "Hamartomatous polyposis", "Hammertoe", "Hamstring contractures", "Hand apraxia", "Hand clenching", "Hand muscle weakness", "Hand oligodactyly", "Hand polydactyly", "Hand tremor", "Handgrip myotonia", "Happy demeanor", "Hashimoto thyroiditis", "Head banging", "Head titubation", "Head tremor", "Headache", "Heart block", "Heat intolerance", "Heinz bodies", "Hemangioblastoma", "Hemangiomatosis", "Hematological neoplasm", "Hemianopia", "Hemiatrophy", "Hemifacial spasm", "Hemihypertrophy", "Hemimegalencephaly", "Hemiparesis", "Hemiplegia", "Hemiplegia hemiparesis", "Hemivertebrae", "Hemoglobinuria", "Hemolytic anemia", "Hemophagocytosis", "Hemoptysis", "Hemorrhage of the eye", "Heparan sulfate excretion in urine", "Hepatic cysts", "Hepatic encephalopathy", "Hepatic failure", "Hepatic fibrosis", "Hepatic necrosis", "Hepatitis", "Hepatoblastoma", "Hepatocellular adenoma", "Hepatocellular carcinoma", "Hepatomegaly", "Hepatosplenomegaly", "Hereditary nonpolyposis colorectal carcinoma", "Hernia", "Herpes simplex encephalitis", "Heterochromia iridis", "Heterogeneous", "Heteronymous hemianopia", "Heterophoria", "Heterotaxy", "Heterotropia", "Hiatus hernia", "High anterior hairline", "High forehead", "High frequency hearing impairment", "High frequency sensorineural hearing impairment", "High hypermetropia", "High myopia", "High narrow palate", "High palate", "High pitched voice", "Highly arched eyebrow", "Hip contracture", "Hip dislocation", "Hip dysplasia", "Hip flexor weakness", "Hip osteoarthritis", "Hip pain", "Hip subluxation", "Hirsutism", "Hoarse cry", "Hoarse voice", "Hodgkin lymphoma", "Holoprosencephaly", "Homocystinuria", "Honeycomb lung", "Horizontal eyebrow", "Horizontal nystagmus", "Horizontal pendular nystagmus", "Horizontal ribs", "Horseshoe kidney", "Humeroradial synostosis", "Hydranencephaly", "Hydrocele testis", "Hydrocephalus", "Hydrops fetalis", "Hydroureter", "Hydroxyprolinuria", "Hyperactive deep tendon reflexes", "Hyperactive patellar reflex", "Hyperactivity", "Hyperacusis", "Hyperaldosteronism", "Hyperammonemia", "Hyperautofluorescent retinal lesion", "Hypercalcemia", "Hyperchloremic acidosis", "Hypercholesterolemia", "Hypercoagulability", "Hyperconvex fingernails", "Hyperconvex nail", "Hyperesthesia", "Hyperextensibility at wrists", "Hyperextensibility of the finger joints", "Hyperextensibility of the knee", "Hyperextensible skin", "Hypergalactosemia", "Hyperglycemia", "Hypergonadotropic hypogonadism", "Hypergranulosis", "Hyperhidrosis", "Hyperhomocystinemia", "Hyperinsulinemic hypoglycemia", "Hyperintensity of cerebral white matter on mri", "Hyperkalemia", "Hyperkeratosis", "Hyperkeratotic papule", "Hyperketonemia", "Hyperkinetic movements", "Hyperlipidemia", "Hyperlipoproteinemia", "Hyperlordosis", "Hypermagnesemia", "Hypermethioninemia", "Hypermetric saccades", "Hypermetropia", "Hypernatriuria", "Hyperorality", "Hyperostosis", "Hyperoxaluria", "Hyperparathyroidism", "Hyperphenylalaninemia", "Hyperphosphatemia", "Hyperphosphaturia", "Hyperpigmentation in sun exposed areas", "Hyperpigmentation of the skin", "Hyperpituitarism", "Hyperplasia of the maxilla", "Hyperreflexia", "Hyperreflexia in upper limbs", "Hypersomnia", "Hypersplenism", "Hypertelorism", "Hypertension associated with pheochromocytoma", "Hypertensive crisis", "Hyperthyroidism", "Hypertonia", "Hypertrichosis", "Hypertriglyceridemia", "Hypertrophic cardiomyopathy", "Hypertrophic nerve changes", "Hyperuricemia", "Hyperuricosuria", "Hyperventilation", "Hypoamylasemia", "Hypocalcemia", "Hypocalcemic seizures", "Hypocalcemic tetany", "Hypocalciuria", "Hypochloremia", "Hypocholesterolemia", "Hypochromia", "Hypochromic anemia", "Hypochromic microcytic anemia", "Hypodontia", "Hypoglycemic coma", "Hypoglycemic seizures", "Hypogonadism", "Hypogonadotropic hypogonadism", "Hypohidrosis", "Hypoinsulinemia", "Hypointensity of cerebral white matter on mri", "Hypokalemia", "Hypokalemic alkalosis", "Hypokalemic metabolic alkalosis", "Hypoketotic hypoglycemia", "Hypokinesia", "Hypolipidemia", "Hypolipoproteinemia", "Hypomelanotic macule", "Hypomethioninemia", "Hypometric saccades", "Hypomimic face", "Hypoparathyroidism", "Hypophosphatemia", "Hypophosphatemic rickets", "Hypopigmentation of the fundus", "Hypopigmentation of the skin", "Hypopigmented macule", "Hypopigmented skin patches", "Hypopituitarism", "Hypoplasia of penis", "Hypoplasia of teeth", "Hypoplasia of the brainstem", "Hypoplasia of the corpus callosum", "Hypoplasia of the ear cartilage", "Hypoplasia of the epiglottis", "Hypoplasia of the femoral head", "Hypoplasia of the fovea", "Hypoplasia of the frontal lobes", "Hypoplasia of the iris", "Hypoplasia of the musculature", "Hypoplasia of the odontoid process", "Hypoplasia of the olfactory bulb", "Hypoplasia of the pons", "Hypoplasia of the radius", "Hypoplasia of the uterus", "Hypoplasia of the vagina", "Hypoplasia of the ventral pons", "Hypoplastic anemia", "Hypoplastic aortic arch", "Hypoplastic cervical vertebrae", "Hypoplastic dermoepidermal hemidesmosomes", "Hypoplastic facial bones", "Hypoplastic female external genitalia", "Hypoplastic fifth fingernail", "Hypoplastic fifth toenail", "Hypoplastic fingernail", "Hypoplastic frontal sinuses", "Hypoplastic heart", "Hypoplastic helices", "Hypoplastic hippocampus", "Hypoplastic ilia", "Hypoplastic iris stroma", "Hypoplastic ischia", "Hypoplastic labia majora", "Hypoplastic labia minora", "Hypoplastic nipples", "Hypoplastic pelvis", "Hypoplastic pubic rami", "Hypoplastic spleen", "Hypoplastic toenails", "Hypoplastic vertebral bodies", "Hypoproteinemia", "Hyporeflexia", "Hyporeflexia of lower limbs", "Hyporeflexia of upper limbs", "Hyposmia", "Hypotelorism", "Hypotension", "Hypothalamic gonadotropin releasing hormone deficiency", "Hypothalamic hamartoma", "Hypothalamic hypothyroidism", "Hypothermia", "Hypotriglyceridemia", "Hypouricemia", "Hypoventilation", "Hypovolemic shock", "Hypsarrhythmia", "Ichthyosis", "Ileus", "Immotile sperm", "Immune dysregulation", "Immunodeficiency", "Immunologic hypersensitivity", "Impacted tooth", "Impaired adp induced platelet aggregation", "Impaired antigen specific response", "Impaired collagen induced platelet aggregation", "Impaired distal proprioception", "Impaired distal tactile sensation", "Impaired distal vibration sensation", "Impaired epinephrine induced platelet aggregation", "Impaired glucose tolerance", "Impaired horizontal smooth pursuit", "Impaired lymphocyte transformation with phytohemagglutinin", "Impaired mastication", "Impaired neutrophil bactericidal activity", "Impaired oropharyngeal swallow response", "Impaired pain sensation", "Impaired proprioception", "Impaired smooth pursuit", "Impaired social interactions", "Impaired t cell function", "Impaired tactile sensation", "Impaired tandem gait", "Impaired temperature sensation", "Impaired use of nonverbal behaviors", "Impaired vibration sensation at ankles", "Impaired vibration sensation in the lower limbs", "Impaired vibratory sensation", "Impaired visuospatial constructive cognition", "Impairment in personality functioning", "Impairment of activities of daily living", "Impotence", "Inability to walk", "Inappropriate antidiuretic hormone secretion", "Inappropriate behavior", "Inappropriate crying", "Inappropriate laughter", "Inappropriate sexual behavior", "Incisor macrodontia", "Incomitant strabismus", "Incomplete partition of the cochlea type ii", "Incomplete penetrance", "Incomprehensible speech", "Incoordination", "Increased adipose tissue", "Increased arm span", "Increased aspartate family amino acid level in urine", "Increased b cell count", "Increased blood pressure", "Increased blood urea nitrogen", "Increased body mass index", "Increased body weight", "Increased bone mineral density", "Increased c peptide level", "Increased cerebral lipofuscin", "Increased circulating acth level", "Increased circulating androgen concentration", "Increased circulating antibody level", "Increased circulating cortisol level", "Increased circulating gonadotropin level", "Increased circulating iga level", "Increased circulating igg level", "Increased circulating igm level", "Increased circulating interleukin 6", "Increased circulating lactate dehydrogenase concentration", "Increased circulating prolactin concentration", "Increased circulating renin level", "Increased connective tissue", "Increased csf lactate", "Increased density of long bones", "Increased endomysial connective tissue", "Increased fecal porphyrin", "Increased female libido", "Increased fibular diameter", "Increased head circumference", "Increased hepatic glycogen content", "Increased hepatocellular lipid droplets", "Increased intracranial pressure", "Increased intramyocellular lipid droplets", "Increased laxity of ankles", "Increased ldl cholesterol concentration", "Increased level of hippuric acid in urine", "Increased level of l fucose in urine", "Increased mean corpuscular hemoglobin concentration", "Increased mean corpuscular volume", "Increased megakaryocyte count", "Increased muscle fatiguability", "Increased muscle glycogen content", "Increased muscle lipid content", "Increased nuchal translucency", "Increased overbite", "Increased proteinogenic amino acid level in urine", "Increased sensitivity to ionizing radiation", "Increased serine family amino acid in urine", "Increased serum iron", "Increased serum lactate", "Increased serum pyruvate", "Increased serum serotonin", "Increased serum testosterone level", "Increased skull ossification", "Increased sulfur amino acid level in urine", "Increased susceptibility to fractures", "Increased theta frequency activity in eeg", "Increased total bilirubin", "Increased urinary cortisol level", "Increased urinary non proteinogenic amino acid level", "Increased urine alpha ketoglutarate concentration", "Increased urine proteinogenic amino acid derivative level", "Increased vertebral height", "Ineffective esophageal peristalsis", "Infantile axial hypotonia", "Infantile encephalopathy", "Infantile muscular hypotonia", "Infantile onset", "Infantile spasms", "Infection related seizure", "Infectious encephalitis", "Inferior lens subluxation", "Inferior vermis hypoplasia", "Infertility", "Inflammation of the large intestine", "Inflammatory abnormality of the eye", "Inflexible adherence to routines or rituals", "Inguinal freckling", "Inguinal hernia", "Insidious onset", "Insomnia", "Inspiratory stridor", "Insulin resistance", "Insulin resistant diabetes mellitus", "Intellectual disability borderline", "Intellectual disability mild", "Intellectual disability moderate", "Intellectual disability profound", "Intellectual disability progressive", "Intellectual disability severe", "Intercostal muscle weakness", "Interictal eeg abnormality", "Intermittent diarrhea", "Intermittent episodes of respiratory insufficiency due to muscle weakness", "Interphalangeal joint erosions", "Interrupted aortic arch", "Interstitial cardiac fibrosis", "Interstitial pneumonitis", "Intestinal atresia", "Intestinal fistula", "Intestinal hypoplasia", "Intestinal malrotation", "Intestinal perforation", "Intestinal polyp", "Intestinal pseudo obstruction", "Intraalveolar phospholipid accumulation", "Intracellular accumulation of autofluorescent lipopigment storage material", "Intracranial hemorrhage", "Intracranial meningioma", "Intractable diarrhea", "Intrauterine growth retardation", "Intrinsic hand muscle atrophy", "Intussusception", "Inverted nipples", "Involuntary movements", "Iridocyclitis", "Iris atrophy", "Iris coloboma", "Iris hypopigmentation", "Iron accumulation in brain", "Iron accumulation in globus pallidus", "Iron deficiency anemia", "Irregular epiphyses", "Irregular femoral epiphysis", "Irregular hyperpigmentation", "Irregular menstruation", "Irregular vertebral endplates", "Irritability", "Ischemic stroke", "J shaped sella turcica", "Jaundice", "Jerky head movements", "Joint contracture of the hand", "Joint contractures involving the joints of the feet", "Joint dislocation", "Joint hemorrhage", "Joint hyperflexibility", "Joint hypermobility", "Joint laxity", "Joint stiffness", "Joint subluxation", "Joint swelling", "Juvenile aseptic necrosis", "Juvenile cataract", "Juvenile myelomonocytic leukemia", "Juvenile onset", "Juvenile rheumatoid arthritis", "Keloids", "Keratitis", "Keratoconjunctivitis", "Keratosis pilaris", "Ketoacidosis", "Ketonuria", "Ketosis", "Ketotic hypoglycemia", "Kinetic tremor", "Knee clonus", "Knee dislocation", "Knee flexion contracture", "Kyphoscoliosis", "Kyphosis", "Labial hypertrophy", "Lack of insight", "Lack of peer relationships", "Lack of skin elasticity", "Lack of t cell function", "Lacrimal duct atresia", "Lacrimal duct stenosis", "Lacrimation abnormality", "Lactic acidosis", "Lacticaciduria", "Lactose intolerance", "Lagopthalmos", "Lambdoidal craniosynostosis", "Language impairment", "Large basal ganglia", "Large beaked nose", "Large earlobe", "Large face", "Large fleshy ears", "Large for gestational age", "Large foramen magnum", "Large forehead", "Large hands", "Large iliac wing", "Large intestinal polyposis", "Large placenta", "Large sella turcica", "Laryngeal cleft", "Laryngeal dystonia", "Laryngeal hypoplasia", "Laryngeal stenosis", "Laryngeal stridor", "Laryngomalacia", "Laryngotracheomalacia", "Late onset", "Lateral clavicle hook", "Leber optic atrophy", "Left atrial enlargement", "Left bundle branch block", "Left to right shunt", "Left ventricular hypertrophy", "Left ventricular noncompaction cardiomyopathy", "Left ventricular outflow tract obstruction", "Left ventricular systolic dysfunction", "Leg muscle stiffness", "Leiomyosarcoma", "Lens subluxation", "Lenticonus", "Lethal skeletal dysplasia", "Lethargy", "Leukemia", "Leukocytosis", "Leukodystrophy", "Leukoencephalopathy", "Leukonychia", "Leukopenia", "Lewy bodies", "Leydig cell neoplasia", "Lichenification", "Limb ataxia", "Limb dysmetria", "Limb dystonia", "Limb fasciculations", "Limb girdle muscle atrophy", "Limb girdle muscle weakness", "Limb girdle muscular dystrophy", "Limb hypertonia", "Limb joint contracture", "Limb muscle weakness", "Limb myoclonus", "Limb pain", "Limb tremor", "Limb undergrowth", "Limitation of joint mobility", "Limitation of knee mobility", "Limitation of movement at ankles", "Limitation of neck motion", "Limited elbow extension", "Limited elbow movement", "Limited extraocular movements", "Limited hip extension", "Limited hip movement", "Limited knee extension", "Limited wrist extension", "Limited wrist movement", "Lingual dystonia", "Lipid accumulation in hepatocytes", "Lipoatrophy", "Lipodystrophy", "Lipoma", "Lissencephaly", "Liver abscess", "Lobar holoprosencephaly", "Localized hirsutism", "Localized osteoporosis", "Localized skin lesion", "Long clavicles", "Long ear", "Long eyelashes", "Long fingers", "Long foot", "Long hallux", "Long neck", "Long nose", "Long palm", "Long palpebral fissure", "Long penis", "Long philtrum", "Long thorax", "Long toe", "Long tract signs", "Long upper lip", "Lop ear", "Loss of ability to walk", "Loss of consciousness", "Loss of eyelashes", "Loss of purkinje cells in the cerebellar vermis", "Loss of speech", "Loss of subcutaneous adipose tissue in limbs", "Loss of voice", "Low alkaline phosphatase", "Low anterior hairline", "Low apgar score", "Low back pain", "Low frustration tolerance", "Low grade fever", "Low hanging columella", "Low levels of vitamin d", "Low molecular weight proteinuria", "Low plasma citrulline", "Low posterior hairline", "Low set nipples", "Low set posteriorly rotated ears", "Lower extremity joint dislocation", "Lower eyelid coloboma", "Lower limb amyotrophy", "Lower limb asymmetry", "Lower limb hyperreflexia", "Lower limb hypertonia", "Lower limb metaphyseal irregularity", "Lower limb muscle weakness", "Lower limb pain", "Lower limb spasticity", "Lower limb undergrowth", "Lumbar hyperlordosis", "Lumbar kyphosis", "Lumbar scoliosis", "Lung adenocarcinoma", "Lymphangiectasis", "Lymphangioma", "Lymphedema", "Lymphocytosis", "Lymphoma", "Lymphopenia", "Lymphoproliferative disorder", "Macrocephaly at birth", "Macrocytic anemia", "Macrodactyly", "Macrodontia", "Macrodontia of permanent maxillary central incisor", "Macroglossia", "Macrogyria", "Macroorchidism", "Macroscopic hematuria", "Macrotia", "Macrovesicular hepatic steatosis", "Macular atrophy", "Macular coloboma", "Macular degeneration", "Macular hyperpigmentation", "Macular hypoplasia", "Macular purpura", "Macular thickening", "Macule", "Malabsorption", "Malar prominence", "Malar rash", "Male hypogonadism", "Male infertility", "Male pseudohermaphroditism", "Male reproductive system neoplasm", "Male sexual dysfunction", "Malignant genitourinary tract tumor", "Malignant hyperthermia", "Malignant neoplasm of the central nervous system", "Malnutrition", "Malrotation of small bowel", "Mandibular aplasia", "Mandibular prognathia", "Mania", "Mask like facies", "Mastoiditis", "Maternal diabetes", "Maternal hypertension", "Maturity onset diabetes of the young", "Meconium stained amniotic fluid", "Medial flaring of the eyebrow", "Median cleft lip", "Median cleft palate", "Mediastinal lymphadenopathy", "Medullary nephrocalcinosis", "Medulloblastoma", "Megalencephaly", "Megaloblastic anemia", "Megalocornea", "Melanocytic nevus", "Melanoma", "Melena", "Membranoproliferative glomerulonephritis", "Memory impairment", "Meningioma", "Meningitis", "Meningocele", "Menorrhagia", "Mental deterioration", "Mesoaxial hand polydactyly", "Mesoaxial polydactyly", "Mesomelia", "Metabolic acidosis", "Metabolic alkalosis", "Metacarpophalangeal joint contracture", "Metamorphopsia", "Metaphyseal chondrodysplasia", "Metaphyseal cupping", "Metaphyseal dysplasia", "Metaphyseal irregularity", "Metaphyseal sclerosis", "Metaphyseal spurs", "Metaphyseal striations", "Metaphyseal widening", "Metatarsal synostosis", "Metatarsus adductus", "Metatarsus valgus", "Methemoglobinemia", "Methylmalonic acidemia", "Methylmalonic aciduria", "Metopic synostosis", "Metrorrhagia", "Microcornea", "Microcytic anemia", "Microdontia", "Microglossia", "Micrographia", "Micromelia", "Micronodular cirrhosis", "Micropenis", "Microphallus", "Microretrognathia", "Microscopic hematuria", "Microtia third degree", "Microvesicular hepatic steatosis", "Middle age onset", "Midface retrusion", "Midline defect of the nose", "Migraine", "Mild global developmental delay", "Mild hearing impairment", "Mild microcephaly", "Mild postnatal growth retardation", "Mild short stature", "Mildly elevated creatine kinase", "Milia", "Minicore myopathy", "Minimal change glomerulonephritis", "Misalignment of incisors", "Missing ribs", "Mitochondrial inheritance", "Mitochondrial myopathy", "Mitochondrial respiratory chain defects", "Mitral stenosis", "Mitral valve calcification", "Mitral valve prolapse", "Mitten deformity", "Mixed demyelinating and axonal polyneuropathy", "Mixed hearing impairment", "Mixed hypo and hyperpigmentation of the skin", "Moderate albuminuria", "Moderate global developmental delay", "Moderate sensorineural hearing impairment", "Moderately reduced visual acuity", "Molar tooth sign on mri", "Molluscoid pseudotumors", "Molluscum contagiosum", "Monochromacy", "Monocytosis", "Monotonic speech", "Mood swings", "Morning glory anomaly", "Morning myoclonic jerks", "Morphological abnormality of the corticospinal tract", "Morphological abnormality of the middle ear", "Morphological abnormality of the pyramidal tract", "Morphological abnormality of the vestibule of the inner ear", "Mortality aging", "Motor axonal neuropathy", "Motor delay", "Motor deterioration", "Motor neuron atrophy", "Motor polyneuropathy", "Motor regression", "Motor seizure", "Motor tics", "Mottled pigmentation", "Movement abnormality of the tongue", "Moyamoya phenomenon", "Mucosal telangiectasiae", "Multicystic kidney dysplasia", "Multifactorial inheritance", "Multifocal cerebral white matter abnormalities", "Multifocal epileptiform discharges", "Multifocal seizures", "Multiple cafe au lait spots", "Multiple enchondromatosis", "Multiple exostoses", "Multiple gastric polyps", "Multiple glomerular cysts", "Multiple impacted teeth", "Multiple joint contractures", "Multiple joint dislocation", "Multiple lentigines", "Multiple lipomas", "Multiple mitochondrial dna deletions", "Multiple myeloma", "Multiple prenatal fractures", "Multiple renal cysts", "Multiple rib fractures", "Multiple rows of eyelashes", "Multiple suture craniosynostosis", "Muscle abnormality related to mitochondrial dysfunction", "Muscle fiber atrophy", "Muscle fiber inclusion bodies", "Muscle fiber necrosis", "Muscle fiber splitting", "Muscle fiber tubular inclusions", "Muscle fibrillation", "Muscle flaccidity", "Muscle hypertrophy of the lower extremities", "Muscle spasm", "Muscle stiffness", "Muscle weakness", "Muscular dystrophy", "Muscular hypotonia of the trunk", "Muscular ventricular septal defect", "Mutism", "Myalgia", "Mydriasis", "Myelodysplasia", "Myelofibrosis", "Myeloid leukemia", "Myelomeningocele", "Myelopathy", "Myeloproliferative disorder", "Myocardial fibrosis", "Myoclonic seizure", "Myoclonic spasms", "Myoclonus", "Myofibrillar myopathy", "Myoglobinuria", "Myokymia", "Myopathic facies", "Myopathy", "Myopia", "Myositis", "Myotonia", "Naevus flammeus of the eyelid", "Nail dysplasia", "Nail dystrophy", "Nail pits", "Narrow face", "Narrow foot", "Narrow foramen obturatorium", "Narrow forehead", "Narrow iliac wing", "Narrow internal auditory canal", "Narrow jaw", "Narrow mouth", "Narrow nasal bridge", "Narrow nasal ridge", "Narrow nose", "Narrow palate", "Narrow palm", "Narrow palpebral fissure", "Narrow pelvis bone", "Narrow vertebral interpedicular distance", "Nasal congestion", "Nasal regurgitation", "Nasal speech", "Nasogastric tube feeding", "Nasogastric tube feeding in infancy", "Nasolacrimal duct obstruction", "Natal tooth", "Nausea", "Nausea and vomiting", "Neck flexor weakness", "Neck muscle weakness", "Negativism", "Nemaline bodies", "Neonatal alloimmune thrombocytopenia", "Neonatal asphyxia", "Neonatal breathing dysregulation", "Neonatal death", "Neonatal hyperbilirubinemia", "Neonatal hypoglycemia", "Neonatal hypotonia", "Neonatal insulin dependent diabetes mellitus", "Neonatal onset", "Neonatal respiratory distress", "Neoplasm", "Neoplasm by histology", "Neoplasm of fatty tissue", "Neoplasm of head and neck", "Neoplasm of striated muscle", "Neoplasm of the adrenal cortex", "Neoplasm of the adrenal gland", "Neoplasm of the breast", "Neoplasm of the colon", "Neoplasm of the ear", "Neoplasm of the endocrine system", "Neoplasm of the eye", "Neoplasm of the gallbladder", "Neoplasm of the gastrointestinal tract", "Neoplasm of the genitourinary tract", "Neoplasm of the heart", "Neoplasm of the inner ear", "Neoplasm of the large intestine", "Neoplasm of the larynx", "Neoplasm of the liver", "Neoplasm of the male external genitalia", "Neoplasm of the middle ear", "Neoplasm of the nervous system", "Neoplasm of the oral cavity", "Neoplasm of the pancreas", "Neoplasm of the parathyroid gland", "Neoplasm of the peripheral nervous system", "Neoplasm of the pituitary gland", "Neoplasm of the rectum", "Neoplasm of the respiratory system", "Neoplasm of the skeletal system", "Neoplasm of the skin", "Neoplasm of the small intestine", "Neoplasm of the stomach", "Neoplasm of the thyroid gland", "Neoplasm of the tongue", "Neoplasm of the tracheobronchial system", "Nephritis", "Nephrocalcinosis", "Nephrogenic diabetes insipidus", "Nephrolithiasis", "Nephronophthisis", "Nephropathy", "Nephrotic syndrome", "Neuralgia", "Neurodegeneration", "Neuroendocrine neoplasm", "Neurofibrillary tangles", "Neurofibromas", "Neurogenic bladder", "Neuroinflammation", "Neuroma", "Neuromuscular dysphagia", "Neuronal loss in basal ganglia", "Neuronal loss in central nervous system", "Neuronal loss in the cerebral cortex", "Neuropathic arthropathy", "Neutropenia in presence of anti neutropil antibodies", "Nevus", "Night sweats", "No social interaction", "Nocturia", "Nocturnal hypoventilation", "Nocturnal seizures", "Nodular goiter", "Non hodgkin lymphoma", "Non medullary thyroid carcinoma", "Non midline cleft lip", "Non midline cleft palate", "Non motor seizure", "Non obstructive azoospermia", "Noncompaction cardiomyopathy", "Nonimmune hydrops fetalis", "Nonketotic hypoglycemia", "Nonprogressive", "Nonprogressive cerebellar ataxia", "Nonprogressive encephalopathy", "Nonspherocytic hemolytic anemia", "Normochromic anemia", "Normocytic anemia", "Nuclear cataract", "Numerous nevi", "Numerous pigmented freckles", "Nyctalopia", "Nystagmus induced head nodding", "Obsessive compulsive behavior", "Obsessive compulsive trait", "Obstructive sleep apnea", "Occipital cortical atrophy", "Occipital encephalocele", "Occipital meningocele", "Ocular albinism", "Ocular anterior segment dysgenesis", "Ocular pain", "Oculogyric crisis", "Oculomotor apraxia", "Oculomotor nerve palsy", "Odontogenic neoplasm", "Oligoarthritis", "Oligodactyly", "Oligodontia", "Oligohydramnios", "Oligomenorrhea", "Oligosacchariduria", "Oligospermia", "Oliguria", "Olivopontocerebellar atrophy", "Olivopontocerebellar hypoplasia", "Omphalocele", "Onion bulb formation", "Onset", "Onychogryposis", "Onychogryposis of toenails", "Onycholysis", "Onychomycosis", "Open angle glaucoma", "Open bite", "Open mouth", "Open operculum", "Ophthalmoparesis", "Opisthotonus", "Opportunistic infection", "Opsoclonus", "Optic atrophy", "Optic disc coloboma", "Optic disc hypoplasia", "Optic disc pallor", "Optic nerve compression", "Optic nerve dysplasia", "Optic nerve hypoplasia", "Optic neuropathy", "Oral aversion", "Oral cavity bleeding", "Oral cleft", "Oral leukoplakia", "Oral mucosal blisters", "Oral pharyngeal dysphagia", "Oral ulcer", "Orchitis", "Organic aciduria", "Orofacial dyskinesia", "Oromandibular dystonia", "Oromotor apraxia", "Oroticaciduria", "Orthopnea", "Orthostatic hypotension", "Orthostatic hypotension due to autonomic dysfunction", "Osteoarthritis", "Osteochondroma", "Osteochondrosis", "Osteolysis", "Osteolysis involving bones of the feet", "Osteolysis involving bones of the upper limbs", "Osteolytic defects of the distal phalanges of the hand", "Osteomalacia", "Osteomyelitis", "Osteopenia", "Osteopetrosis", "Osteoporosis", "Osteosarcoma", "Otitis media", "Otosclerosis", "Oval face", "Ovarian carcinoma", "Ovarian cyst", "Ovarian gonadoblastoma", "Ovarian neoplasm", "Ovarian papillary adenocarcinoma", "Overfolding of the superior helices", "Overfriendliness", "Overgrowth", "Overhanging nasal tip", "Overlapping fingers", "Overlapping toe", "Overriding aorta", "Overtubulated long bones", "Overweight", "Ovoid vertebral bodies", "Ovotestis", "Oxycephaly", "Pace of progression", "Pain", "Pain in head and neck region", "Pain insensitivity", "Painless fractures due to injury", "Palate fistula", "Pallor", "Palmar hyperhidrosis", "Palmar pits", "Palmar telangiectasia", "Palmoplantar blistering", "Palmoplantar cutis laxa", "Palmoplantar hyperhidrosis", "Palpebral edema", "Palpitations", "Pancreatic adenocarcinoma", "Pancreatic cysts", "Pancreatic fibrosis", "Pancreatic hypoplasia", "Pancreatic islet cell hyperplasia", "Pancreatitis", "Pancytopenia", "Panhypogammaglobulinemia", "Panhypopituitarism", "Panniculitis", "Papillary renal cell carcinoma", "Papillary thyroid carcinoma", "Papilledema", "Papilloma", "Papule", "Paracentral scotoma", "Paraganglioma", "Parakeratosis", "Paralysis", "Paranoia", "Paraparesis", "Paraplegia", "Paraplegia paraparesis", "Parasomnia", "Parathyroid adenoma", "Parathyroid carcinoma", "Paresthesia", "Parietal bossing", "Parietal cortical atrophy", "Parietal foramina", "Parkinsonism", "Parkinsonism with favorable response to dopaminergic medication", "Paronychia", "Paroxysmal bursts of laughter", "Paroxysmal dystonia", "Paroxysmal involuntary eye movements", "Paroxysmal ventricular tachycardia", "Partial absence of thumb", "Partial agenesis of the corpus callosum", "Partial anomalous pulmonary venous return", "Partial duplication of the distal phalanges of the hand", "Partial duplication of the phalanx of hand", "Patchy alopecia", "Patchy changes of bone mineral density", "Patchy hypopigmentation of hair", "Patchy palmoplantar hyperkeratosis", "Patellar aplasia", "Patellar dislocation", "Patellar hypoplasia", "Patellar subluxation", "Patent ductus arteriosus", "Patent foramen ovale", "Pathologic fracture", "Pectus carinatum", "Pectus excavatum", "Pectus excavatum of inferior sternum", "Pedal edema", "Pediatric onset", "Peg shaped maxillary lateral incisors", "Pelvic girdle muscle weakness", "Pelvic kidney", "Pendular nystagmus", "Penetrating foot ulcers", "Peptic ulcer", "Perianal abscess", "Periauricular skin pits", "Pericardial effusion", "Pericarditis", "Perifoveal ring of hyperautofluorescence", "Perimembranous ventricular septal defect", "Periodic paralysis", "Periodontitis", "Periorbital edema", "Periorbital fullness", "Peripheral arterial stenosis", "Peripheral axonal degeneration", "Peripheral axonal neuropathy", "Peripheral cyanosis", "Peripheral demyelination", "Peripheral edema", "Peripheral hypermyelination", "Peripheral hypomyelination", "Peripheral neuropathy", "Peripheral opacification of the cornea", "Peripheral pulmonary artery stenosis", "Peripheral retinal avascularization", "Peripheral visual field loss", "Periportal fibrosis", "Perisylvian polymicrogyria", "Peritoneal abscess", "Peritonitis", "Periventricular cysts", "Periventricular heterotopia", "Periventricular leukomalacia", "Periventricular nodular heterotopia", "Periventricular white matter hyperintensities", "Peroneal muscle atrophy", "Perseveration", "Persistence of hemoglobin f", "Persistence of primary teeth", "Persistent ebv viremia", "Persistent head lag", "Personality changes", "Personality disorder", "Pes cavus", "Pes planus", "Pes valgus", "Petechiae", "Peters anomaly", "Phalangeal dislocation", "Pharyngitis", "Phenotypic variability", "Pheochromocytoma", "Phimosis", "Phocomelia", "Phonophobia", "Photophobia", "Photopsia", "Photoreceptor layer loss on macular oct", "Phthisis bulbi", "Physical urticaria", "Pierre robin sequence", "Pigmentary retinopathy", "Pili canaliculi", "Pili torti", "Pilomatrixoma", "Pineal cyst", "Pituitary adenoma", "Pituitary growth hormone cell adenoma", "Pituitary hypothyroidism", "Pituitary prolactin cell adenoma", "Plagiocephaly", "Plantar hyperkeratosis", "Platybasia", "Platyspondyly", "Pleural effusion", "Pleuritis", "Pneumonia", "Pneumothorax", "Poikilocytosis", "Poikiloderma", "Pointed chin", "Polar cataract", "Pollakisuria", "Polyarticular arthropathy", "Polyclonal elevation of igm", "Polycystic kidney dysplasia", "Polycystic liver disease", "Polycythemia", "Polydactyly", "Polygenic inheritance", "Polyhydramnios", "Polymicrogyria", "Polyneuropathy", "Polyphagia", "Polysplenia", "Polyuria", "Pontocerebellar atrophy", "Poor appetite", "Poor coordination", "Poor eye contact", "Poor fine motor coordination", "Poor gross motor coordination", "Poor head control", "Poor motor coordination", "Poor speech", "Poor suck", "Poor wound healing", "Porencephalic cyst", "Porokeratosis", "Porphyrinuria", "Portal fibrosis", "Portal vein thrombosis", "Positional foot deformity", "Positive romberg sign", "Post partum hemorrhage", "Postaxial foot polydactyly", "Postaxial hand polydactyly", "Postaxial polydactyly", "Posterior blepharitis", "Posterior embryotoxon", "Posterior fossa cyst", "Posterior pharyngeal cleft", "Posterior pituitary dysgenesis", "Posterior polar cataract", "Posterior rib cupping", "Posterior subcapsular cataract", "Posterior uveitis", "Posteriorly rotated ears", "Postexertional malaise", "Postnatal growth retardation", "Postural instability", "Postural tremor", "Potter facies", "Preauricular skin tag", "Preaxial foot polydactyly", "Preaxial hand polydactyly", "Preaxial polydactyly", "Precocious atherosclerosis", "Predominantly lower limb lymphedema", "Prelingual sensorineural hearing impairment", "Premature adrenarche", "Premature arteriosclerosis", "Premature birth", "Premature coronary artery atherosclerosis", "Premature graying of hair", "Premature loss of primary teeth", "Premature loss of teeth", "Premature osteoarthritis", "Premature ovarian insufficiency", "Premature pubarche", "Premature rupture of membranes", "Premature skin wrinkling", "Premature thelarche", "Premature ventricular contraction", "Prematurely aged appearance", "Prenatal maternal abnormality", "Prenatal movement abnormality", "Primary adrenal insufficiency", "Primary amenorrhea", "Primary congenital glaucoma", "Primary gonadal insufficiency", "Primary hypercortisolism", "Primary hyperparathyroidism", "Primary microcephaly", "Primary peritoneal carcinoma", "Primitive neuroectodermal tumor", "Primitive reflex", "Productive cough", "Profound global developmental delay", "Profound hearing impairment", "Profound sensorineural hearing impairment", "Progeroid facial appearance", "Progressive", "Progressive cerebellar ataxia", "Progressive distal muscle weakness", "Progressive encephalopathy", "Progressive external ophthalmoplegia", "Progressive extrapyramidal movement disorder", "Progressive flexion contractures", "Progressive gait ataxia", "Progressive hearing impairment", "Progressive inability to walk", "Progressive leukoencephalopathy", "Progressive macrocephaly", "Progressive microcephaly", "Progressive muscle weakness", "Progressive neurologic deterioration", "Progressive night blindness", "Progressive peripheral neuropathy", "Progressive pes cavus", "Progressive proximal muscle weakness", "Progressive psychomotor deterioration", "Progressive pulmonary function impairment", "Progressive sensorineural hearing impairment", "Progressive spastic paraparesis", "Progressive spastic paraplegia", "Progressive spastic quadriplegia", "Progressive spasticity", "Progressive visual field defects", "Progressive visual loss", "Prolinuria", "Prolonged bleeding following procedure", "Prolonged bleeding time", "Prolonged neonatal jaundice", "Prolonged partial thromboplastin time", "Prolonged pr interval", "Prolonged qtc interval", "Prominent antihelix", "Prominent antitragus", "Prominent calcaneus", "Prominent crus of helix", "Prominent digit pad", "Prominent ear helix", "Prominent eyelashes", "Prominent forehead", "Prominent metopic ridge", "Prominent nasal bridge", "Prominent nasal tip", "Prominent nasolabial fold", "Prominent nose", "Prominent occiput", "Prominent sternum", "Prominent superficial blood vessels", "Prominent supraorbital ridges", "Prominent umbilicus", "Prominent veins on trunk", "Proportionate short stature", "Proportionate tall stature", "Proptosis", "Prostate neoplasm", "Protein avoidance", "Protein losing enteropathy", "Protruding ear", "Protruding tongue", "Protrusio acetabuli", "Protuberant abdomen", "Proximal amyotrophy", "Proximal femoral epiphysiolysis", "Proximal femoral metaphyseal abnormality", "Proximal femoral metaphyseal irregularity", "Proximal muscle weakness", "Proximal muscle weakness in lower limbs", "Proximal muscle weakness in upper limbs", "Proximal renal tubular acidosis", "Proximal symphalangism", "Proximal tubulopathy", "Proximal upper limb amyotrophy", "Pruritus", "Pseudoarthrosis", "Pseudobulbar paralysis", "Pseudobulbar signs", "Pseudoepiphyses", "Pseudoepiphyses of hand bones", "Pseudoepiphyses of the metacarpals", "Pseudohypoaldosteronism", "Pseudohypoparathyroidism", "Psoriasiform dermatitis", "Psychogenic non epileptic seizure", "Psychomotor deterioration", "Psychomotor retardation", "Psychosis", "Psychotic episodes", "Psychotic mentation", "Pterygium", "Ptosis", "Puberty and gonadal disorders", "Pulmonary artery atresia", "Pulmonary artery dilatation", "Pulmonary artery hypoplasia", "Pulmonary artery stenosis", "Pulmonary carcinoid tumor", "Pulmonary cyst", "Pulmonary edema", "Pulmonary embolism", "Pulmonary fibrosis", "Pulmonary hemorrhage", "Pulmonary hypoplasia", "Pulmonary infiltrates", "Pulmonary insufficiency", "Pulmonary interstitial high resolution computed tomography abnormality", "Pulmonary venous hypertension", "Pulmonic stenosis", "Pulverulent cataract", "Punctate cataract", "Pure red cell aplasia", "Purpura", "Pustule", "Pyelonephritis", "Pyoderma gangrenosum", "Pyridoxine responsive sideroblastic anemia", "Quadriceps muscle weakness", "Radial bowing", "Radial deviation of the 2nd finger", "Radial deviation of the hand", "Radial deviation of the hand or of fingers of the hand", "Radioulnar dislocation", "Radioulnar synostosis", "Ragged red muscle fibers", "Rapidly progressive", "Raynaud phenomenon", "Reactive hypoglycemia", "Receptive language delay", "Rectal abscess", "Rectal fistula", "Rectal prolapse", "Recurrent", "Recurrent abscess formation", "Recurrent acute respiratory tract infection", "Recurrent aspergillus infections", "Recurrent aspiration pneumonia", "Recurrent bacterial infections", "Recurrent bacterial skin infections", "Recurrent bronchitis", "Recurrent bronchopulmonary infections", "Recurrent corneal erosions", "Recurrent cutaneous abscess formation", "Recurrent ear infections", "Recurrent fever", "Recurrent fractures", "Recurrent gastroenteritis", "Recurrent hand flapping", "Recurrent herpes", "Recurrent hypoglycemia", "Recurrent infection of the gastrointestinal tract", "Recurrent joint dislocation", "Recurrent lower respiratory tract infections", "Recurrent mycobacterial infections", "Recurrent opportunistic infections", "Recurrent otitis media", "Recurrent pancreatitis", "Recurrent paroxysmal headache", "Recurrent pharyngitis", "Recurrent pneumonia", "Recurrent respiratory infections", "Recurrent sinopulmonary infections", "Recurrent sinusitis", "Recurrent skin infections", "Recurrent staphylococcal infections", "Recurrent staphylococcus aureus infections", "Recurrent tonsillitis", "Recurrent upper and lower respiratory tract infections", "Recurrent urinary tract infections", "Recurrent viral infections", "Red eye", "Red green dyschromatopsia", "Red hair", "Reduced antigen specific t cell proliferation", "Reduced antithrombin iii activity", "Reduced brain n acetyl aspartate level by mrs", "Reduced c peptide level", "Reduced circulating prolactin concentration", "Reduced consciousness confusion", "Reduced delayed hypersensitivity", "Reduced factor xi activity", "Reduced factor xii activity", "Reduced factor xiii activity", "Reduced forced expiratory volume in one second", "Reduced forced vital capacity", "Reduced natural killer cell count", "Reduced pancreatic beta cells", "Reduced protein c activity", "Reduced protein s activity", "Reduced renal corticomedullary differentiation", "Reduced sperm motility", "Reduced subcutaneous adipose tissue", "Reduced systolic function", "Reduced tendon reflexes", "Reduced visual acuity", "Reduced vital capacity", "Reduction of neutrophil motility", "Redundant neck skin", "Redundant skin", "Refractory anemia", "Regional abnormality of skin", "Relative macrocephaly", "Renal agenesis", "Renal cell carcinoma", "Renal cortical cysts", "Renal cortical microcysts", "Renal corticomedullary cysts", "Renal cyst", "Renal duplication", "Renal dysplasia", "Renal fanconi syndrome", "Renal fibrosis", "Renal hamartoma", "Renal hypoplasia", "Renal hypoplasia aplasia", "Renal insufficiency", "Renal magnesium wasting", "Renal malrotation", "Renal phosphate wasting", "Renal potassium wasting", "Renal salt wasting", "Renal steatosis", "Renal tubular acidosis", "Renal tubular atrophy", "Renal tubular dysfunction", "Renal tubular epithelial necrosis", "Renovascular hypertension", "Repetitive compulsive behavior", "Respiratory alkalosis", "Respiratory arrest", "Respiratory distress", "Respiratory failure", "Respiratory failure requiring assisted ventilation", "Respiratory insufficiency", "Respiratory insufficiency due to defective ciliary clearance", "Respiratory paralysis", "Respiratory tract infection", "Response to drugs acting on neuromuscular transmission", "Resting tremor", "Restless legs", "Restlessness", "Restrictive behavior", "Restrictive cardiomyopathy", "Restrictive ventilatory defect", "Reticular hyperpigmentation", "Reticulated skin pigmentation", "Reticulocytopenia", "Reticulocytosis", "Retinal arterial tortuosity", "Retinal arteriolar tortuosity", "Retinal atrophy", "Retinal coloboma", "Retinal degeneration", "Retinal detachment", "Retinal dysplasia", "Retinal dystrophy", "Retinal fold", "Retinal hamartoma", "Retinal hemorrhage", "Retinal neovascularization", "Retinal perforation", "Retinal pigment epithelial atrophy", "Retinal pigment epithelial mottling", "Retinal telangiectasia", "Retinal thinning", "Retinal vascular tortuosity", "Retinopathy", "Retrocollis", "Retrognathia", "Rhabdomyolysis", "Rhabdomyosarcoma", "Rhegmatogenous retinal detachment", "Rheumatoid arthritis", "Rheumatoid factor positive", "Rhinitis", "Rhizomelia", "Rib fusion", "Rib segmentation abnormalities", "Rickets", "Ridged nail", "Rieger anomaly", "Right bundle branch block", "Right ventricular cardiomyopathy", "Right ventricular dilatation", "Right ventricular hypertrophy", "Rigidity", "Rimmed vacuoles", "Rod cone dystrophy", "Rotary nystagmus", "Round ear", "Round face", "Saccadic oscillation", "Saccadic smooth pursuit", "Sacrococcygeal teratoma", "Sagittal craniosynostosis", "Sandal gap", "Sarcoma", "Scaling skin", "Scanning speech", "Scaphocephaly", "Scapular winging", "Scarring", "Scarring alopecia of scalp", "Schistocytosis", "Schizencephaly", "Schizophrenia", "Schwannoma", "Scleral staphyloma", "Sclerocornea", "Scleroderma", "Sclerosis of hand bone", "Sclerosis of skull base", "Sclerotic vertebral endplates", "Scotoma", "Scrotal hypoplasia", "Sea blue histiocytosis", "Seborrheic dermatitis", "Second degree atrioventricular block", "Secondary amenorrhea", "Secondary growth hormone deficiency", "Secondary microcephaly", "Secretory diarrhea", "Secundum atrial septal defect", "Segmental peripheral demyelination remyelination", "Selective tooth agenesis", "Self injurious behavior", "Self mutilation", "Semilobar holoprosencephaly", "Senile plaques", "Sensorimotor neuropathy", "Sensory ataxia", "Sensory axonal neuropathy", "Sensory neuropathy", "Sepsis", "Septate vagina", "Septic arthritis", "Septo optic dysplasia", "Serositis", "Severe b lymphocytopenia", "Severe combined immunodeficiency", "Severe cytomegalovirus infection", "Severe demyelination of the white matter", "Severe expressive language delay", "Severe failure to thrive", "Severe global developmental delay", "Severe hearing impairment", "Severe infection", "Severe intrauterine growth retardation", "Severe lactic acidosis", "Severe muscular hypotonia", "Severe photosensitivity", "Severe platyspondyly", "Severe postnatal growth retardation", "Severe short limb dwarfism", "Severe short stature", "Severe varicella zoster infection", "Severe viral infection", "Severely reduced visual acuity", "Sex reversal", "Shagreen patch", "Shallow acetabular fossae", "Shallow anterior chamber", "Shallow orbits", "Shawl scrotum", "Shield chest", "Shock", "Short 1st metacarpal", "Short attention span", "Short chin", "Short clavicles", "Short columella", "Short digit", "Short face", "Short femur", "Short foot", "Short fourth metatarsal", "Short lingual frenulum", "Short long bone", "Short lower limbs", "Short middle phalanx of finger", "Short nail", "Short nose", "Short palm", "Short palpebral fissure", "Short phalanx of the thumb", "Short philtrum", "Short proximal phalanx of finger", "Short ribs", "Short stepped shuffling gait", "Short sternum", "Short thorax", "Short thumb", "Short tibia", "Short umbilical cord", "Short upper lip", "Shortened pr interval", "Shortened qt interval", "Shortening of all distal phalanges of the fingers", "Shortening of all middle phalanges of the fingers", "Shoulder dislocation", "Shoulder girdle muscle atrophy", "Shoulder girdle muscle weakness", "Shoulder pain", "Shuffling gait", "Shyness", "Sick sinus syndrome", "Sideroblastic anemia", "Simple ear", "Simple febrile seizure", "Simplified gyral pattern", "Single fiber emg abnormality", "Single naris", "Single transverse palmar crease", "Single ventricle", "Sinus bradycardia", "Sinus tachycardia", "Sirenomelia", "Skeletal dysplasia", "Skeletal muscle atrophy", "Skeletal muscle hypertrophy", "Skeletal myopathy", "Skin appendage neoplasm", "Skin dimple", "Skin erosion", "Skin nodule", "Skin picking", "Skin pit", "Skin plaque", "Skin rash", "Skin tags", "Skin ulcer", "Skin vesicle", "Skull asymmetry", "Slanting of the palpebral fissure", "Sleep apnea", "Sleep disturbance", "Sleep wake cycle disturbance", "Slender build", "Slender finger", "Slender long bone", "Slender toe", "Sloping forehead", "Slow decrease in visual acuity", "Slow pupillary light response", "Slow saccadic eye movements", "Slowly progressive", "Slurred speech", "Small anterior fontanelle", "Small basal ganglia", "Small cerebral cortex", "Small earlobe", "Small epiphyses", "Small face", "Small for gestational age", "Small hand", "Small intestinal dysmotility", "Small nail", "Small pituitary gland", "Small placenta", "Smooth muscle antibody positivity", "Smooth philtrum", "Snoring", "Social and occupational deterioration", "Soft doughy skin", "Soft skin", "Soft tissue sarcoma", "Solitary median maxillary central incisor", "Somatic mosaicism", "Somatic mutation", "Somatic sensory dysfunction", "Sound sensitivity", "Sparse and thin eyebrow", "Sparse body hair", "Sparse eyebrow", "Sparse eyelashes", "Sparse hair", "Sparse lateral eyebrow", "Sparse or absent eyelashes", "Sparse scalp hair", "Spastic ataxia", "Spastic diplegia", "Spastic dysarthria", "Spastic gait", "Spastic hyperactive bladder", "Spastic paraparesis", "Spastic paraparetic gait", "Spastic paraplegia", "Spastic tetraparesis", "Spastic tetraplegia", "Spasticity", "Specific learning disability", "Speech apraxia", "Speech articulation difficulties", "Spider hemangioma", "Spina bifida", "Spina bifida occulta", "Spinal canal stenosis", "Spinal cord compression", "Spinal cord lesion", "Spinal cord tumor", "Spinal deformities", "Spinal muscular atrophy", "Spinal rigidity", "Spinocerebellar tract degeneration", "Splanchnic vein thrombosis", "Splenomegaly", "Split nail", "Spoken word recognition deficit", "Spondyloepimetaphyseal dysplasia", "Spondyloepiphyseal dysplasia", "Spondylolisthesis", "Spondylolysis", "Spontaneous abortion", "Spontaneous hematomas", "Spontaneous hemolytic crises", "Spontaneous pain sensation", "Spontaneous recurrent epistaxis", "Sporadic", "Spotty hyperpigmentation", "Spotty hypopigmentation", "Sprengel anomaly", "Squamous cell carcinoma", "Squamous cell carcinoma of the skin", "Square face", "Squared iliac bones", "St segment elevation", "Stage 5 chronic kidney disease", "Staring gaze", "Status epilepticus", "Status epilepticus with prominent motor symptoms", "Stenosis of the external auditory canal", "Steppage gait", "Stereotypical body rocking", "Stereotypical hand wringing", "Stereotypy", "Steroid resistant nephrotic syndrome", "Stiff skin", "Stillbirth", "Stomach cancer", "Stomatitis", "Stomatocytosis", "Stooped posture", "Streak ovary", "Striae distensae", "Stridor", "Stroke", "Stroke like episode", "Stuttering", "Subacute progressive viral hepatitis", "Subarachnoid hemorrhage", "Subcapsular cataract", "Subcortical band heterotopia", "Subcortical cerebral atrophy", "Subcortical heterotopia", "Subcutaneous hemorrhage", "Subcutaneous nodule", "Subdural hemorrhage", "Subependymal cysts", "Subglottic stenosis", "Submucous cleft of soft and hard palate", "Submucous cleft soft palate", "Subretinal fluid", "Subsarcolemmal accumulations of abnormally shaped mitochondria", "Substantia nigra gliosis", "Subvalvular aortic stenosis", "Sudden death", "Sudden episodic apnea", "Sudden loss of visual acuity", "Suicidal ideation", "Sunken cheeks", "Supernumerary bones of the axial skeleton", "Supernumerary nipple", "Supernumerary spleens", "Supernumerary tooth", "Supranuclear gaze palsy", "Supranuclear ophthalmoplegia", "Supravalvular aortic stenosis", "Supraventricular arrhythmia", "Supraventricular tachycardia", "Swan neck like deformities of the fingers", "Symphalangism affecting the phalanges of the hand", "Symphalangism of middle phalanx of finger", "Symptomatic seizures", "Syncope", "Syndactyly", "Synostosis involving bones of the hand", "Synostosis involving bones of the lower limbs", "Synostosis involving bones of the upper limbs", "Synostosis involving digits", "Synostosis of carpal bones", "Synostosis of carpals tarsals", "Synostosis of joints", "Synostosis of metacarpals metatarsals", "Synovitis", "Syringomyelia", "Systemic lupus erythematosus", "T cell lymphoma", "T lymphocytopenia", "Tachycardia", "Tachypnea", "Talipes calcaneovalgus", "Talipes equinovalgus", "Talipes equinovarus", "Talipes valgus", "Tall chin", "Tall stature", "Tapered distal phalanges of finger", "Tapered finger", "Tarsal synostosis", "Telangiectasia", "Telangiectasia of the skin", "Telecanthus", "Temperature instability", "Temporal cortical atrophy", "Temporal optic disc pallor", "Temporal pattern", "Tendon xanthomatosis", "Tented upper lip vermilion", "Teratoma", "Testicular adrenal rest tumor", "Testicular atrophy", "Testicular dysgenesis", "Tetany", "Tetralogy of fallot", "Tetraparesis", "Tetraplegia", "Tetraplegia tetraparesis", "Thenar muscle atrophy", "Thick cerebral cortex", "Thick corpus callosum", "Thick eyebrow", "Thick hair", "Thick lower lip vermilion", "Thick nasal alae", "Thick upper lip vermilion", "Thick vermilion border", "Thickened calvaria", "Thickened cortex of long bones", "Thickened ears", "Thickened helices", "Thickened nuchal skin fold", "Thickened ribs", "Thickened skin", "Thin bony cortex", "Thin clavicles", "Thin eyebrow", "Thin lower lip vermilion", "Thin nail", "Thin ribs", "Thin skin", "Thin upper lip vermilion", "Thin vermilion border", "Thinning of descemet membrane", "Third degree atrioventricular block", "Thoracic aortic aneurysm", "Thoracic hypoplasia", "Thoracic kyphoscoliosis", "Thoracic kyphosis", "Thoracic scoliosis", "Thoracolumbar kyphoscoliosis", "Thoracolumbar kyphosis", "Thoracolumbar scoliosis", "Thrombocytosis", "Thromboembolism", "Thymus hyperplasia", "Thyroid adenoma", "Thyroid carcinoma", "Thyroiditis", "Tibial bowing", "Tibial torsion", "Tibialis muscle weakness", "Tics", "Tiger tail banding", "Tinnitus", "Tip toe gait", "Tissue ischemia", "Titubation", "Toe clinodactyly", "Toe syndactyly", "Toe walking", "Toenail dysplasia", "Tongue atrophy", "Tongue fasciculations", "Tongue nodules", "Tongue thrusting", "Tonic seizure", "Tooth malposition", "Torsade de pointes", "Torsion dystonia", "Total anomalous pulmonary venous return", "Toxemia of pregnancy", "Tracheal stenosis", "Tracheobronchomalacia", "Tracheoesophageal fistula", "Tracheomalacia", "Tractional retinal detachment", "Transient global amnesia", "Transient ischemic attack", "Transient neonatal diabetes mellitus", "Transient neutropenia", "Transposition of the great arteries", "Tremor", "Tremor by anatomical site", "Triangular face", "Triangular mouth", "Triangular shaped phalanges of the hand", "Triceps weakness", "Trichorrhexis nodosa", "Tricuspid atresia", "Tricuspid stenosis", "Tricuspid valve prolapse", "Trigonocephaly", "Triphalangeal thumb", "Trismus", "Tritanomaly", "Trophic changes related to pain", "True hermaphroditism", "Truncal ataxia", "Truncal obesity", "Truncal titubation", "Truncus arteriosus", "Tube feeding", "Tubulointerstitial nephritis", "Turricephaly", "Type 1 fibers relatively smaller than type 2 fibers", "Type 1 muscle fiber atrophy", "Type 2 muscle fiber atrophy", "Type 2 muscle fiber predominance", "Type i diabetes mellitus", "Type i transferrin isoform profile", "Type ii diabetes mellitus", "Type ii lissencephaly", "Type ii transferrin isoform profile", "Typical absence seizure", "U shaped upper lip vermilion", "Ulcerative colitis", "Ulnar bowing", "Ulnar claw", "Ulnar deviation of finger", "Ulnar deviation of the 2nd finger", "Ulnar deviation of the hand", "Ulnar deviation of the hand or of fingers of the hand", "Ulnar deviation of the wrist", "Uncombable hair", "Unconjugated hyperbilirubinemia", "Underdeveloped nasal alae", "Underdeveloped supraorbital ridges", "Underdeveloped tragus", "Undetectable electroretinogram", "Undetectable light and dark adapted electroretinogram", "Undetectable visual evoked potentials", "Unexplained fevers", "Unilateral cleft palate", "Unilateral ptosis", "Unilateral renal agenesis", "Unsteady gait", "Unusual fungal infection", "Unusual infection", "Unusual infection by anatomical site", "Unusual skin infection", "Upgaze palsy", "Uplifted earlobe", "Upper airway obstruction", "Upper extremity joint dislocation", "Upper eyelid coloboma", "Upper limb amyotrophy", "Upper limb asymmetry", "Upper limb hypertonia", "Upper limb muscle weakness", "Upper limb pain", "Upper limb postural tremor", "Upper limb spasticity", "Upper limb undergrowth", "Upper motor neuron dysfunction", "Upslanted palpebral fissure", "Ureteral duplication", "Ureteral obstruction", "Ureteral stenosis", "Ureterocele", "Ureteropelvic junction obstruction", "Urethral atresia", "Urethral obstruction", "Urethral stenosis", "Urethral stricture", "Urethral valve", "Urethrovaginal fistula", "Uric acid nephrolithiasis", "Urinary bladder sphincter dysfunction", "Urinary glycosaminoglycan excretion", "Urinary incontinence", "Urinary retention", "Urinary tract neoplasm", "Urinary urgency", "Urogenital fistula", "Urogenital sinus anomaly", "Urticaria", "Uterine prolapse", "Uterus didelphys", "Uveal melanoma", "Uveitis", "Vacuolated lymphocytes", "Vaginal atresia", "Vaginal fistula", "Vaginal neoplasm", "Variable expressivity", "Varicose veins", "Vascular calcification", "Vascular dilatation", "Vascular neoplasm", "Vascular skin abnormality", "Vascular tortuosity", "Vasculitis", "Vegetative state", "Vein of galen aneurysmal malformation", "Velopharyngeal insufficiency", "Venous insufficiency", "Venous malformation", "Venous thrombosis", "Ventilator dependence with inability to wean", "Ventricular arrhythmia", "Ventricular escape rhythm", "Ventricular fibrillation", "Ventricular hypertrophy", "Ventricular preexcitation", "Ventricular septal hypertrophy", "Ventricular tachycardia", "Ventriculomegaly", "Verrucae", "Vertebral arch anomaly", "Vertebral clefting", "Vertebral compression fracture", "Vertebral fusion", "Vertebral hypoplasia", "Vertebral segmentation defect", "Vertebral wedging", "Vertical nystagmus", "Vertical supranuclear gaze palsy", "Vertigo", "Very long chain fatty acid accumulation", "Vestibular dysfunction", "Viral encephalitis", "Viral hepatitis", "Viral infection induced rhabdomyolysis", "Visceral angiomatosis", "Visual acuity test abnormality", "Visual agnosia", "Visual field defect", "Visual fixation instability", "Visual hallucinations", "Visual impairment", "Visual loss", "Vitamin b12 deficiency", "Vitiligo", "Vitreoretinopathy", "Vitreous floaters", "Vitreous hemorrhage", "Vitritis", "Vocal cord paralysis", "Vocal cord paresis", "Volvulus", "Vomiting", "Waddling gait", "Weak cry", "Weak voice", "Weakness due to upper motor neuron dysfunction", "Weakness of facial musculature", "Weakness of long finger extensor muscles", "Weakness of muscles of respiration", "Weakness of the intrinsic hand muscles", "Webbed neck", "Weight loss", "Wheezing", "White forelock", "White hair", "Wide anterior fontanel", "Wide cranial sutures", "Wide intermamillary distance", "Wide mouth", "Wide nasal bridge", "Wide nasal ridge", "Wide nose", "Widely patent fontanelles and sutures", "Widely spaced incisors", "Widely spaced teeth", "Widened cerebral subarachnoid space", "Widened subarachnoid space", "Widow s peak", "Woolly hair", "Wormian bones", "Wrist flexion contracture", "Writer s cramp", "X linked dominant inheritance", "X linked recessive inheritance", "Xanthelasma", "Xanthomatosis", "Xerostomia", "Yellow white lesions of the retina", "Young adult onset", "Zonular cataract"], "available_proteins": ["AAAS", "AARS", "AARS2", "AASS", "ABCB1", "ABCB6", "ABCB7", "ABCD3", "ABHD12", "ACACA", "ACAD9", "ACADM", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACBD5", "ACO2", "ACOX1", "ACP2", "ACSF3", "ACSL4", "ACTL6A", "ACTN1", "ACTN4", "ADA", "ADAR", "ADD1", "ADD3", "ADH5", "ADK", "ADNP", "ADSL", "AFG3L2", "AGK", "AGL", "AGPS", "AHCY", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AKAP10", "AKAP9", "AKT2", "ALDH18A1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDOA", "ALG1", "ALG11", "ANAPC1", "ANAPC2", "ANK3", "ANKFY1", "ANKLE2", "ANKRD17", "ANLN", "ANO10", "ANO6", "ANXA11", "AP1B1", "AP1S1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "APP", "APPL1", "APRT", "ARCN1", "ARHGDIA", "ARHGEF2", "ARID1A", "ARID2", "ARL2", "ARL3", "ARL6IP1", "ARVCF", "ASAH1", "ASNA1", "ASNS", "ASPH", "ASPSCR1", "ATAD1", "ATAD3A", "ATIC", "ATP1A1", "ATP2A2", "ATP2B4", "ATP2C1", "ATP5A1", "ATP6AP1", "ATP6AP2", "ATP6V0A2", "ATP6V1A", "ATP6V1B2", "ATP6V1E1", "ATP7A", "ATP7B", "ATRIP", "ATXN10", "AURKA", "B3GALT6", "B4GAT1", "BAG3", "BANF1", "BARD1", "BAZ1B", "BCAP31", "BCKDK", "BCR", "BCS1L", "BICD2", "BLM", "BLVRA", "BMS1", "BPTF", "BRCA1", "BRD4", "BUB1B", "BUB3", "BUD23", "C19orf70", "C1QBP", "CAD", "CALD1", "CALR", "CAMK2G", "CANT1", "CAPN1", "CARS", "CASK", "CAST", "CBX2", "CC2D1A", "CCDC22", "CCDC47", "CCT5", "CD2AP", "CD3EAP", "CDC42", "CDC73", "CDH2", "CDK4", "CDK5", "CDK6", "CDKN2A", "CELF2", "CEP55", "CFL2", "CHAMP1", "CHD1", "CHD4", "CHD8", "CHMP2B", "CHMP4B", "CHORDC1", "CHST14", "CIB1", "CISD2", "CIT", "CIZ1", "CLASP1", "CLCC1", "CLCN7", "CLN5", "CLPB", "CLPP", "CLPX", "CLTC", "CNNM4", "CNOT1", "CNP", "COA3", "COA7", "COG2", "COG4", "COG5", "COG6", "COG7", "COL4A3BP", "COLEC12", "COLGALT1", "COMT", "COPA", "COPB1", "COPB2", "COQ8A", "COQ9", "COX15", "COX2", "COX4I1", "COX5A", "CPNE1", "CPOX", "CPSF1", "CPT1A", "CPT2", "CRKL", "CRTAP", "CSNK2A1", "CSNK2B", "CSTB", "CTBP1", "CTNNA1", "CTNNB1", "CTNND1", "CTPS1", "CTSA", "CTSC", "CTU2", "CUL3", "CUL4B", "CWF19L1", "CXorf56", "CYB5R3", "CYC1", "CYFIP2", "DARS", "DARS2", "DBT", "DCAF8", "DCPS", "DCTN1", "DCTN4", "DCXR", "DDB1", "DDOST", "DDRGK1", "DDX3X", "DDX41", "DDX6", "DHCR24", "DHCR7", "DHFR", "DHPS", "DHTKD1", "DHX16", "DHX30", "DHX37", "DHX38", "DIAPH1", "DIAPH2", "DIAPH3", "DICER1", "DKC1", "DLAT", "DLD", "DLG1", "DLST", "DNA2", "DNAAF5", "DNAJC13", "DNAJC21", "DNAJC3", "DNM1L", "DNM2", "DNMT1", "DOCK7", "DPF2", "DPM1", "DPP9", "DPYSL5", "DSC3", "DSG2", "DSP", "DST", "DYNC1H1", "DYNC1I2", "DYNC2H1", "DYNLL1", "EARS2", "EBP", "ECE1", "ECHS1", "EDC3", "EEF1A2", "EEF2", "EFL1", "EFTUD2", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF3F", "EIF4A3", "EIF4G1", "EIF4H", "EIF5A", "ELAC2", "ELMO2", "ELP1", "ELP2", "ELP4", "EMC1", "EMD", "EMG1", "EPB41", "EPHX2", "EPRS", "EPS15L1", "ERAL1", "ERAP1", "ERCC2", "ERCC3", "ERGIC1", "ERLIN1", "ERLIN2", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXOC2", "EXOC7", "EXOC8", "EXOSC1", "EXOSC2", "EXOSC3", "EXOSC8", "EXOSC9", "EYA4", "EZR", "FAH", "FAM50A", "FANCD2", "FANCI", "FAR1", "FARSA", "FARSB", "FASN", "FDFT1", "FDPS", "FDXR", "FECH", "FH", "FHL1", "FIP1L1", "FKBP10", "FKBP14", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FMR1", "FOXC1", "FOXRED1", "FSCN1", "FTO", "FUCA1", "FUS", "FXR1", "G6PD", "GAA", "GALK1", "GALM", "GALNS", "GALNT2", "GANAB", "GAPVD1", "GARS", "GATAD2B", "GATB", "GBA", "GCDH", "GCLC", "GDAP1", "GDI1", "GEMIN4", "GEMIN5", "GFM1", "GFPT1", "GGCX", "GIGYF2", "GLA", "GLB1", "GLDC", "GLE1", "GLMN", "GLRX5", "GLS", "GLUD1", "GM2A", "GNAI2", "GNAI3", "GNAQ", "GNE", "GNPAT", "GNS", "GOT2", "GPAA1", "GPD1L", "GPD2", "GPHN", "GPI", "GPKOW", "GPRASP2", "GPT2", "GRHPR", "GSR", "GSS", "GSTM3", "GTF2E2", "GTF2I", "GTPBP3", "GUF1", "GYG1", "GYS1", "H2AFY", "HADH", "HADHA", "HADHB", "HARS2", "HAX1", "HCCS", "HCFC1", "HELLS", "HEXA", "HEXB", "HIBCH", "HIRA", "HIST1H1E", "HK1", "HLA-A", "HLA-B", "HLA-C", "HMBS", "HMGA1", "HMGB3", "HMGCL", "HMMR", "HMOX1", "HNRNPA1", "HNRNPA2B1", "HNRNPDL", "HNRNPH2", "HNRNPK", "HNRNPU", "HPRT1", "HPS6", "HS2ST1", "HSD17B10", "HSD17B4", "HSPA9", "HSPD1", "HTT", "HUWE1", "HYOU1", "IARS", "IARS2", "IDH1", "IDH2", "IDH3A", "IDH3B", "IFT27", "IFT81", "IGBP1", "IGF2BP2", "IGF2R", "IKBKB", "IMPAD1", "IMPDH1", "INF2", "INPPL1", "INTS1", "INTS8", "IQCB1", "IRF2BPL", "IRS4", "ITCH", "ITPA", "IVD", "JAGN1", "JUP", "KARS", "KDM1A", "KDM3B", "KDSR", "KIAA0319L", "KIDINS220", "KIF11", "KIF14", "KIF1A", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF4A", "KIFBP", "KMT2A", "L2HGDH", "LAMB1", "LAMC1", "LAMP2", "LARP7", "LARS", "LARS2", "LAS1L", "LBR", "LDHA", "LDLR", "LEMD3", "LETM1", "LIPA", "LLGL1", "LMAN2L", "LMNA", "LMNB1", "LMNB2", "LNPK", "LONP1", "LRBA", "LRP1", "LRPAP1", "LRPPRC", "LRSAM1", "LSS", "LZTFL1", "MACF1", "MAGED2", "MAGT1", "MALT1", "MAN2B1", "MAP1B", "MAPK1", "MAPRE2", "MARS", "MARS2", "MAT2A", "MATR3", "MBOAT7", "MCCC1", "MCCC2", "MCM10", "MCM2", "MCM4", "MCM5", "MCM6", "MCM7", "MDH1", "MDH2", "MECP2", "MED17", "MED23", "MESD", "MFN2", "MIA3", "MICU1", "MIF", "MINPP1", "MIPEP", "MMAB", "MOCOS", "MOGS", "MORC2", "MPG", "MPI", "MPV17", "MRE11", "MRPL12", "MRPL3", "MRPL44", "MRPS16", "MRPS22", "MRPS23", "MRPS25", "MRPS28", "MRPS34", "MRPS35", "MRPS7", "MSH2", "MSH3", "MSH6", "MSMO1", "MSN", "MSTO1", "MTAP", "MTCH1", "MTHFD1", "MTHFS", "MTMR14", "MTMR2", "MTO1", "MTOR", "MTPAP", "MTR", "MTX2", "MUT", "MVD", "MYH14", "MYH9", "MYO6", "NAA10", "NAA15", "NAGLU", "NANS", "NARS", "NAXE", "NBAS", "NBN", "NCAPD2", "NCAPD3", "NCAPG2", "NCAPH", "NCDN", "NCSTN", "ND1", "NDUFA10", "NDUFA11", "NDUFA13", "NDUFA4", "NDUFA8", "NDUFA9", "NDUFAF2", "NDUFAF3", "NDUFAF4", "NDUFB10", "NDUFB3", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS6", "NDUFS7", "NDUFS8", "NDUFV1", "NDUFV2", "NEDD4L", "NEFL", "NEK9", "NELFA", "NEMF", "NF1", "NFKBIL1", "NFS1", "NFU1", "NHLRC2", "NHP2", "NIPBL", "NNT", "NONO", "NOP56", "NOTCH2", "NPC1", "NPC2", "NPM1", "NSD1", "NSD2", "NSDHL", "NSF", "NSMCE2", "NSUN2", "NT5C2", "NT5C3A", "NTHL1", "NUBPL", "NUMA1", "NUP107", "NUP133", "NUP155", "NUP160", "NUP188", "NUP205", "NUP214", "NUP37", "NUP62", "NUP85", "NUP88", "NUP93", "NXN", "OAT", "OCLN", "OCRL", "OGDH", "OGT", "OPA1", "OPA3", "OSGEP", "P3H1", "P4HA2", "P4HB", "PABPN1", "PAFAH1B1", "PALLD", "PARK7", "PARN", "PBRM1", "PC", "PCBD1", "PCCA", "PCCB", "PCNA", "PDCD6", "PDHA1", "PDHB", "PDHX", "PDK3", "PDP1", "PDSS2", "PEPD", "PEX11B", "PEX14", "PEX19", "PEX3", "PFKM", "PFN1", "PGK1", "PGM1", "PGM3", "PHB", "PHF6", "PHGDH", "PHIP", "PHKA1", "PHKB", "PI4KA", "PICALM", "PIGG", "PIGK", "PIGS", "PIGT", "PIGU", "PIK3C2A", "PIK3R2", "PISD", "PITRM1", "PKN1", "PLAA", "PLD3", "PLEC", "PLOD1", "PLOD2", "PLOD3", "PLS3", "PMPCA", "PMPCB", "PMVK", "PNKP", "PNP", "PNPLA6", "PNPLA8", "PNPT1", "POFUT1", "POGZ", "POLA1", "POLD1", "POLE", "POLG", "POLR1A", "POLR1B", "POLR1C", "POLR2A", "POLR3A", "POLR3B", "PON2", "POP1", "POR", "PPA2", "PPIB", "PPOX", "PPP1CB", "PPP2R1A", "PPP2R1B", "PPP2R5D", "PPP3CA", "PPT1", "PQBP1", "PRCC", "PREPL", "PRKACA", "PRKAR1A", "PRKCSH", "PRKDC", "PRPF3", "PRPF31", "PRPF4", "PRPF6", "PRPF8", "PSAP", "PSAT1", "PSMB4", "PSMC3", "PSMD12", "PSMG2", "PTCD3", "PTDSS1", "PTPN1", "PTPN11", "PTPN23", "PTPRF", "PTRH2", "PUF60", "PURA", "PUS1", "PUS7", "PXMP2", "PYCR1", "PYCR2", "PYGL", "QARS", "QDPR", "QRSL1", "RAB18", "RAB23", "RAB3GAP1", "RAB3GAP2", "RAB7A", "RABL3", "RAC1", "RAD21", "RAD50", "RALA", "RANBP2", "RAPGEF2", "RARS", "RARS2", "RBM10", "RBM12", "RBM28", "RBM8A", "RBMX", "RBPJ", "RDH11", "RDX", "RFC1", "RFC2", "RFT1", "RINT1", "RIPK1", "RNASEH2A", "RNASET2", "RNF2", "ROBO1", "RP2", "RPL10", "RPL11", "RPL13", "RPL15", "RPL18", "RPL21", "RPL26", "RPL27", "RPL31", "RPL35", "RPL35A", "RPL5", "RPS10", "RPS14", "RPS15A", "RPS17", "RPS19", "RPS20", "RPS23", "RPS24", "RPS26", "RPS28", "RPS29", "RPS6KA3", "RPS7", "RPSA", "RRAS2", "RREB1", "RSPRY1", "RTN2", "RTN4IP1", "SALL2", "SAMHD1", "SAR1B", "SARS", "SARS2", "SBDS", "SCAF1", "SCARB2", "SCO1", "SCO2", "SCP2", "SCYL1", "SDHA", "SDHB", "SDHC", "SEC23A", "SEC23B", "SEC24C", "SEC31A", "SEC61A1", "SEC63", "SEPT9", "SERPINB6", "SERPINH1", "SET", "SETD1A", "SETD2", "SF3B1", "SF3B4", "SFXN4", "SGPL1", "SH3GL1", "SHMT2", "SIGMAR1", "SIN3A", "SKIV2L", "SLC12A2", "SLC16A1", "SLC19A1", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A19", "SLC25A20", "SLC25A21", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A4", "SLC27A4", "SLC33A1", "SLC39A14", "SLC5A6", "SLC9A3R1", "SLMAP", "SMARCA4", "SMARCAD1", "SMARCB1", "SMARCC2", "SMARCD1", "SMC1A", "SMC3", "SMCHD1", "SMN1*", "SMPD4", "SMS", "SNRNP200", "SNRPE", "SOAT1", "SON", "SORD", "SPART", "SPATA5", "SPECC1L", "SPEN", "SPR", "SPTAN1", "SPTBN1", "SPTLC1", "SPTLC2", "SRC", "SRCAP", "SRP54", "SRP72", "SSBP1", "SSR4", "STAG1", "STAG2", "STAT1", "STAT3", "STK4", "STT3A", "STT3B", "STUB1", "STX16", "STXBP2", "SUCLA2", "SUCLG1", "SUZ12", "SYNE1", "SYNE2", "TAF15", "TAF6", "TALDO1", "TAP1", "TAP2", "TARDBP", "TARS", "TARS2", "TBCD", "TBCE", "TBL1XR1", "TBL2", "TCOF1", "TECR", "TELO2", "TERF2IP", "TFAM", "TFG", "TFRC", "THOC2", "THOC6", "TIA1", "TIMM50", "TJP2", "TKT", "TLK2", "TMCO1", "TMEM126A", "TMEM199", "TMEM43", "TMLHE", "TMPO", "TMPO", "TMTC3", "TMX2", "TNPO3", "TOE1", "TOMM40", "TOP2A", "TOR1A", "TOR1AIP1", "TP53", "TPI1", "TPM3", "TPP1", "TPP2", "TRAPPC11", "TRAPPC4", "TRIM28", "TRIO", "TRIP12", "TRIP13", "TRIP4", "TRMT1", "TRMT10C", "TRMU", "TRRAP", "TSFM", "TTC19", "TTC37", "TUBB", "TUBB2A", "TUBB2B", "TUBB3", "TUBB4A", "TUBB6", "TUBGCP2", "TUFM", "TWNK", "TXNDC15", "UBA1", "UBE3A", "UBE4A", "UBTF", "UFC1", "UFD1", "UFM1", "UGDH", "UGP2", "UMPS", "UNC45A", "UPF3B", "UQCC2", "UQCRB", "UQCRC1", "UQCRC2", "UQCRFS1", "UQCRQ", "UROD", "USMG5", "USP7", "USP9X", "VAMP7", "VANGL1", "VANGL2", "VAPB", "VARS1", "VARS2", "VCL", "VCP", "VIM", "VIPAS39", "VPS13A", "VPS13C", "VPS16", "VPS33A", "VPS33B", "VPS35", "VPS45", "VPS4A", "VPS51", "VPS53", "VRK1", "WARS", "WASHC4", "WASHC5", "WBP11", "WDR1", "WDR11", "WDR26", "WDR36", "WDR4", "WDR73", "WFS1", "WIPI2", "XPNPEP3", "XRCC1", "YARS", "YARS2", "YEATS2", "YME1L1", "YWHAE", "YWHAG", "ZC3H14", "ZCCHC8", "ZFR", "ZMPSTE24", "ZPR1"], "leading_proteins": ["ABCB1", "ABCB6", "ABCB7", "ABCD3", "ABHD12", "ACADVL", "ACBD5", "ACP2", "ADA", "ADAR", "ADD3", "ADK", "AFG3L2", "AGK", "AGL", "AGPS", "AIFM1", "AIP", "AKAP10", "AKT2", "ALDH18A1", "ALDH3A2", "ALG1", "ALG11", "ANKLE2", "ANO10", "ANO6", "AP3B1", "APP", "APPL1", "ARHGDIA", "ARL6IP1", "ASAH1", "ASNA1", "ATAD1", "ATAD3A", "ATP1A1", "ATP2A2", "ATP2C1", "ATP6AP1", "ATP6AP2", "ATP6V0A2", "ATP6V1E1", "ATP7A", "ATP7B", "ATXN10", "B3GALT6", "B4GAT1", "BCAP31", "BCS1L", "BICD2", "BRCA1", "BUB1B", "C19orf70", "CASK", "CCDC47", "CEP55", "CHMP2B", "CHST14", "CIB1", "CIT", "CLCC1", "CLCN7", "CLN5", "CLPB", "CNNM4", "COA3", "COG6", "COLEC12", "COMT", "COQ9", "COX15", "COX2", "COX4I1", "COX5A", "CPOX", "CPT1A", "CPT2", "CTNND1", "CTPS1", "CTSA", "CTSC", "CYC1", "DDRGK1", "DDX41", "DHCR24", "DHCR7", "DHFR", "DHPS", "DLD", "DLG1", "DNA2", "DNAAF5", "DNM2", "DST", "DYNC2H1", "EBP", "ECE1", "EIF2B5", "EIF4H", "EMD", "ERAP1", "ERCC2", "ERGIC1", "ERLIN1", "ERLIN2", "ETFDH", "EWSR1", "EXOC7", "EXOSC3", "FAH", "FANCD2", "FAR1", "FASN", "FDFT1", "FDPS", "FDXR", "FECH", "FKBP10", "FKBP14", "FLII", "FOXRED1", "G6PD", "GAA", "GALNS", "GBA", "GDAP1", "GEMIN4", "GGCX", "GLA", "GLB1", "GLE1", "GM2A", "GNAI2", "GNAI3", "GNAQ", "GNE", "GNPAT", "GNS", "GTPBP3", "HADH", "HADHA", "HAX1", "HCCS", "HELLS", "HEXA", "HLA-A", "HLA-B", "HLA-C", "HMMR", "HMOX1", "HNRNPDL", "HNRNPH2", "HNRNPK", 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sha256:a1140558b218ce32ffe63c63c365fe08cc9acd8b3e52763ef0a0e5d2f0326281 +size 141921 diff --git a/msigdb_kegg/consensus.joblib b/msigdb_kegg/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..5b61ebdb0da67a7c7be35e9493c04cf4cdbdc913 --- /dev/null +++ b/msigdb_kegg/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:c2a636e35b21070e02935b44a5942b6b2b7430274bb8acdf8af9c0272de1fbba +size 85907 diff --git a/msigdb_kegg/df_merge.tsv b/msigdb_kegg/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..08c8895913f185b1ba562e365eb09982e9d598e0 --- /dev/null +++ b/msigdb_kegg/df_merge.tsv @@ -0,0 +1,18 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Lysosome 23 49 3.769416536095302 0.0001636296145981 21.740291262135923 48.609223300970875 0.8281821627988494 0.1302152537326229 7.142313942893836 4.247239237941681 3.086075071395461 0.2389623217115766 8.913206912115784e-13 0.0118453859760169 4.418300680293524e-05 1.5377343574541902e-09 3.4263777933285676e-11 +Oxidative phosphorylation 27 61 3.5067259387851824 0.0004536561216015 18.79854368932039 59.0752427184466 1.0149760730411637 0.3252836463038503 7.263801581344288 4.652138947381941 1.8018345229041028 0.3643612228552857 7.83913637364868e-10 9.028179583440972e-06 4.76055551175879e-08 1.5943182612816704e-07 8.404825480003919e-11 +Parkinsons disease 26 55 3.500765271227443 0.0004639242674635 16.90776699029126 54.04126213592233 1.0315348591123816 0.3152611195514452 7.595108151251147 4.223805209268991 1.8494970521239744 0.3626807692210581 2.8765007830027082e-08 5.301792220889015e-07 3.511094645653378e-09 6.51109102422212e-06 3.033174836702166e-09 +Sphingolipid metabolism 9 12 3.3457830247678904 0.0008205057413404 5.672330097087379 11.759708737864075 0.9805985471070467 0.1821702203806468 2.452838935293596 1.3449033287601222 1.7625559835482287 0.2542774311591588 2.2156380031538172e-08 1.0 8.694316847855437e-05 2.2359581100408143e-05 1.1237436337996233e-07 +Cardiac muscle contraction 12 20 3.283777426165891 0.0010242577881711 7.728155339805825 19.856796116504853 1.0644813600437804 0.240240383706381 3.4195161605095614 1.765741250102918 1.6465694074711887 0.3002212677564749 1.036422750342335e-05 0.0012844156650938 0.0008840144918394 0.000686888501954 4.558635539447923e-05 +Huntingtons disease 27 78 2.903986364915579 0.003684442056276 19.631067961165048 76.91504854368932 0.635715043905642 0.4301008974270168 9.08454389027927 5.4148363920790175 1.5734816663041495 0.3870978376334237 2.625237654925622e-06 7.334818516053075e-05 1.5314617239704726e-06 0.0002537727744554 7.446632692217738e-07 +Alzheimers disease 22 60 2.684092058244066 0.0072727077613554 16.135922330097088 58.91990291262136 0.6161331149111849 0.4362889390372475 6.737157569069632 4.882193919366804 1.448905264905826 0.3805753751040122 9.275897319144127e-05 0.000407082511055 0.0002703653485467 0.0013209176340267 1.918301656149602e-05 +Glycerophospholipid metabolism 8 18 2.600245827304878 0.0093157000517787 5.553398058252427 16.104368932038835 0.8448777148315795 0.3373638196000335 3.045697762577092 2.514285464673758 1.2272389207362138 0.3056726473181033 0.0014581665248008 1.0 1.0 0.1411134338084059 0.001050513287845 +Hypertrophic cardiomyopathy hcm 3 9 2.58908573812279 0.0096231131253585 3.429611650485437 9.101941747572816 0.6486134300733651 0.4298239576137608 1.8675556020784376 1.719193792909202 1.0005513529453438 0.3180395638112931 0.0913429609652801 1.0 0.3339976348230559 0.2691814013824262 0.1451121707049519 +Snare interactions in vesicular transport 8 12 2.553836371152368 0.01065433126912 5.803398058252427 13.6626213592233 0.8920027438628428 0.3386294703372389 3.103034547770364 2.9171839264116786 1.2201519782198902 0.3219991979242683 0.0131785756289622 0.1553991536419083 0.0045096021611559 0.051542815486873 0.0257423149537502 +Calcium signaling pathway 10 19 2.391806246662576 0.0167656904021555 5.735436893203883 16.946601941747574 1.0005800740695592 0.3113014190776675 2.984654368989517 2.3866666657890168 1.2450167285670062 0.3187454651207294 0.0491033002504774 0.2695684389372801 0.0244837275894334 0.0715305134437747 0.0946135485635064 +N glycan biosynthesis 6 15 2.375486775209432 0.0175258204210175 5.849514563106796 16.08252427184466 0.2628189875288922 0.4633396270200485 3.100528416799328 2.9026244296339763 1.1828065880862877 0.3297121354639235 0.0852527239925787 1.0 1.0 0.0756846958642696 0.0469837238449897 +Other glycan degradation 4 7 2.1785813313858187 0.029362784273428 3.966019417475728 7.12378640776699 0.0449593300314452 0.158186848086018 1.7909726921672984 0.8075596903062239 1.9584092358200416 0.2320333335657103 0.0176594629498872 1.0 0.1265462710440741 0.2897526236095206 0.0277461310389573 +Steroid biosynthesis 5 12 2.177060380299186 0.0294760626502685 4.451456310679611 10.919902912621358 0.8535439655720318 0.1867209176898754 2.1463612955879627 1.3314318120676296 1.5430058140543457 0.1933818217769055 1.0251630508283642e-05 0.0652597674910206 0.0077184558590264 4.739959742822594e-07 1.5533184688236115e-06 +Porphyrin and chlorophyll metabolism 4 13 2.153556076398565 0.0312750019923946 3.728155339805826 13.315533980582524 1.2215621624941897 0.2689555702886888 1.770547470360957 1.4201912411596824 1.0389071586082248 0.2908939383930566 0.0010403956302503 0.0040679264544396 0.0155240337321844 0.0011814468070448 0.00223229240551 +Dilated cardiomyopathy 3 7 2.126622072402722 0.0334514970380672 3.0097087378640777 8.393203883495145 0.4535126033788805 0.4859001261794073 1.6428435307790814 1.6853890758730747 0.9621453761461582 0.3132641846990659 0.1041236198515872 1.0 0.3467918934582977 0.2871762535363917 0.1636366172223574 +Amyotrophic lateral sclerosis als 4 10 2.100680444092154 0.0356690271194464 2.895631067961165 10.6626213592233 0.370852905277699 0.5967997021777554 1.8185346549003725 1.5169786407319608 0.6928917746074938 0.2858383041361014 0.2021769550170364 1.0 1.0 1.0 0.0353817250131281 diff --git a/msigdb_kegg/metrics.json b/msigdb_kegg/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..7ade6676551e74e69dd4d0886d03936204a6babb --- /dev/null +++ b/msigdb_kegg/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3221, + "annotations_size": 181, + "title": "Average number of proteins per term", + "value": 16.193370165745858 +} \ No newline at end of file diff --git a/msigdb_kegg/paths.json b/msigdb_kegg/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..eadf5c1dd04ddba09a29341e096cb112457450d2 --- /dev/null +++ b/msigdb_kegg/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/msigdb_kegg/fragment/C201/C201_val_log2fc"} \ No newline at end of file diff --git a/msigdb_kegg/result.tsv b/msigdb_kegg/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..ca469ea5be17b33aeebaadd57b6ef7b94325310a --- /dev/null +++ b/msigdb_kegg/result.tsv @@ -0,0 +1,62 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Lysosome 0.6874502446053697 3.769416536095302 0.0001636296145981 0.0291850286756911 0.0148084801211325 49 P11117,O43681,P54802,P10619,P16278,P50897,P07602,P17900,P06280,Q13510,O15118,P11279,P61916,P04062,O75503,Q14108,Q93050,Q15904,Q9NZJ7,P10253,Q9Y487,P13473,O00203 23 +Oxidative phosphorylation 0.5792989625603311 3.5067259387851824 0.0004536561216015 0.0788481571058446 0.0209925731027259 61 O14949,P06576,P20674,P56385,Q7KZN9,Q9UDW1,P22695,P03886,O43676,O95139,O14548,P14406,P24539,P08574,P00403,Q86Y39,P13073,O95168,O95299,O96000,O75964,Q9Y6M9,P21912,Q93050,Q15904,Q9Y487,P51970 27 +Parkinsons disease 0.6174608642622265 3.500765271227443 0.0004639242674635 0.0805593439276107 0.0209925731027259 55 O14949,P06576,P20674,P05141,Q9UDW1,P22695,P03886,O43676,O95139,P14406,O14548,P24539,P08574,P45880,P00403,P21796,P13073,Q9Y277,O95168,O95299,O96000,Q9Y6M9,P21912,P12236,P51970,P12235 26 +Sphingolipid metabolism 0.8990087881117111 3.3457830247678904 0.0008205057413404 0.1380624854059249 0.0297023078365226 12 P16278,Q16739,O43681,P04062,Q16880,Q13510,O15269,O95470,Q06136 9 +Cardiac muscle contraction 0.7622985707478889 3.283777426165891 0.0010242577881711 0.1692992592782536 0.0308984432764969 20 O14949,P20674,O14548,P14406,P08574,P13073,P00403,Q9UDW1,P05023,P22695,P67936,P16615 12 +Huntingtons disease 0.506697888206987 2.903986364915579 0.003684442056276 0.4873262422792646 0.0849462109072614 78 O14949,P06576,P20674,P05141,Q9UDW1,P22695,O43676,O95139,P14406,O14548,P24539,P08574,P45880,P00403,P21796,Q13561,P13073,Q9Y277,O95168,O95299,O96000,Q9Y6M9,P21912,P12236,P04637,P51970,P12235 27 +Alzheimers disease 0.4986317218098055 2.684092058244066 0.0072727077613554 0.7331771147289268 0.1244131054064215 60 O14949,P06576,P20674,Q92542,Q9UDW1,P22695,O43676,P16615,O95139,O14548,P14406,P24539,P08574,P00403,P05067,P13073,O95168,O95299,O96000,Q9Y6M9,P21912,P51970 22 +Glycerophospholipid metabolism 0.6700210320170156 2.600245827304878 0.0093157000517787 0.8162252807956517 0.1244131054064215 18 O95674,Q9UG56,P35790,Q9HCL2,Q96N66,Q9BVG9,Q92604,Q8NF37 8 +Hypertrophic cardiomyopathy hcm 0.802698747843902 2.58908573812279 0.0096231131253585 0.8262639910848313 0.1244131054064215 9 P50402,P02545,P16615 3 +Snare interactions in vesicular transport 0.7430201911503608 2.553836371152368 0.01065433126912 0.8561207112466986 0.1285622639807156 12 Q86Y82,O15498,O60499,O15400,O75396,Q9P2W9,O95249,Q12981 8 +Calcium signaling pathway 0.6276561867706014 2.3918062466625756 0.0167656904021555 0.9531271383508172 0.1762318609002323 19 P12236,P05141,P23634,P45880,Q9Y277,P20020,P21796,P46020,P12235,P16615 10 +N glycan biosynthesis 0.6589263640728291 2.375486775209432 0.0175258204210175 0.9592500261027193 0.1762318609002323 15 Q16706,Q86YN1,Q9BT22,Q96AA3,P46977,Q2TAA5 6 +Other glycan degradation 0.7829330613740815 2.1785813313858187 0.029362784273428 0.9954573850475876 0.242507606349937 7 Q9BTY2,P04062,P16278,P06865 4 +Steroid biosynthesis 0.6739947226487202 2.177060380299186 0.0294760626502685 0.9955523406933404 0.242507606349937 12 Q15392,Q14534,Q15800,Q16850,Q15125 5 +Porphyrin and chlorophyll metabolism 0.6543190367545545 2.153556076398565 0.0312750019923946 0.9968209910929544 0.2461206678531925 13 P30519,P22830,P09601,Q7KZN9 4 +Dilated cardiomyopathy 0.7718897052121247 2.126622072402722 0.0334514970380672 0.9978841683755896 0.2522800401620906 7 P50402,P02545,P16615 3 +Amyotrophic lateral sclerosis als 0.6909055216701306 2.100680444092154 0.0356690271194464 0.9986038664156248 0.258243756344792 10 P07196,P04637,P07197,Q9BUN8 4 +Glycosaminoglycan degradation 0.7555896340737542 1.913561483791575 0.0556762103995565 0.9999686029785604 0.330554142175762 6 P06865,P16278,P34059,P54802 4 +Glycosphingolipid biosynthesis ganglio series 0.8594793987748826 1.754032347672115 0.0794249645424507 0.9999996875978644 0.3925043260078504 4 P16278,O00400 2 +Renin angiotensin system 0.8571502710395749 1.7445570251880167 0.0810620069265017 0.9999997736379718 0.3925043260078504 4 P52888,P10619 2 +Glycosylphosphatidylinositol gpi anchor biosynthesis 0.7080078233119288 1.691044981629554 0.0908282119166365 0.9999999672721768 0.4109976589227806 6 Q96S52,Q5H8A4,Q92643 3 +Protein export 0.5305551465650599 1.572843309380376 0.1157551045276434 0.999999999786384 0.4457802961596483 15 P67812,Q9Y5M8,Q15070 3 +Proximal tubule bicarbonate reclamation 0.6529131226170033 1.5481066062509272 0.1215966318171548 0.9999999999356404 0.4491630685490823 7 P05023,Q9UBX3 2 +Biosynthesis of unsaturated fatty acids 0.5734806466818382 1.5229685871900556 0.1277665646187242 0.999999999982031 0.4534460430586096 11 Q53GQ0,O15254,P40939,Q9NZ01,O00767 5 +Riboflavin metabolism 0.6399611095159221 1.3654302825616442 0.1721178514507624 0.9999999999999986 0.5541356467687608 6 P11117 1 +Aldosterone regulated sodium reabsorption 0.56608426079482 1.3488257019697123 0.177392957169141 0.9999999999999996 0.5541356467687608 9 P05023,Q96PU5 2 +Glycerolipid metabolism 0.5159868160961224 1.320246002298337 0.1867528975298034 1.0 0.5541356467687608 13 P51648,Q9HCL2,Q53H12 3 +Antigen processing and presentation 0.4666581717205964 1.252216115163057 0.2104911254200896 1.0 0.595295214078691 18 Q03519,Q9UL46,P61289,Q03518,P10321,P27824 6 +O glycan biosynthesis 0.6424895597356002 1.23856796533033 0.2155055377189247 1.0 0.6001000358019289 5 Q8N4A0,Q10472,O43505 3 +Steroid hormone biosynthesis 0.8582975486920792 1.2239211291423642 0.2209819820410468 1.0 0.6060263446883253 3 P21964 1 +Ppar signaling pathway 0.4693701143224595 1.1991518714438372 0.2304688975564288 1.0 0.6226100068315467 16 P48163,Q9UKU0,P50416,O15254,P23786,O00767 6 +Glycosphingolipid biosynthesis globo series 0.8464210937950323 1.1783120881564335 0.2386722104170557 1.0 0.6352892659630456 3 P06280 1 +Glycosaminoglycan biosynthesis chondroitin sulfate 0.8421757215571548 1.162034458189777 0.2452214683482729 1.0 0.6408728471322478 3 Q8N6G5 1 +Autoimmune thyroid disease 0.7099782405968182 1.1369799656249366 0.2555466609476007 1.0 0.6408728471322478 4 P04439,P49327,P10321 3 +Graft versus host disease 0.7099782405968182 1.1369799656249366 0.2555466609476007 1.0 0.6408728471322478 4 P04439,P49327,P10321 3 +Allograft rejection 0.7099782405968182 1.1369799656249366 0.2555466609476007 1.0 0.6408728471322478 4 P04439,P49327,P10321 3 +Ecm receptor interaction 0.589786057482929 1.1216428772463076 0.2620143131921897 1.0 0.6408728471322478 6 Q08722,Q7L0J3 2 +Glycosaminoglycan biosynthesis heparan sulfate 0.8241143567433201 1.092977097949286 0.2744038552821064 1.0 0.6450272442345618 3 Q7LGA3,Q96L58 2 +Cell adhesion molecules cams 0.5014846464278762 0.9865363395374196 0.3238699919581109 1.0 0.732755856805226 9 P01889,P04439,P10321,Q92896,Q16625 5 +Ether lipid metabolism 0.5843731562698031 0.972141068749004 0.3309803733263117 1.0 0.7395981181736101 5 Q8NF37 1 +Vibrio cholerae infection 0.4070699269023381 0.93169175514261 0.3514958486146384 1.0 0.7758627877957264 21 Q93050,P61421,P24390,Q96HE7,P36543,Q15904,P55011,Q9Y487 8 +Butanoate metabolism 0.4156181215919021 0.8575102832679793 0.3911629341417051 1.0 0.8137987480419382 17 P40939,Q9H9P8,P51648 3 +P53 signaling pathway 0.4451434778178815 0.7634251877122722 0.4452098631980408 1.0 0.8646658041860474 11 P04637,O14681 2 +Limonene and pinene degradation 0.4729467829248218 0.7260707276655075 0.4677954129628021 1.0 0.8661099489026669 8 P51648 1 +Tryptophan metabolism 0.405648441334277 0.6781395832469649 0.4976831951675491 1.0 0.882458049745459 14 P40939,P51648 2 +Type i diabetes mellitus 0.5186736163587214 0.6766633387111013 0.4986195822069974 1.0 0.882458049745459 5 P04439,P49327,P10321 3 +Primary immunodeficiency 0.7040628760750054 0.6513462376425951 0.5148230071386044 1.0 0.882458049745459 3 Q03519 1 +Fatty acid metabolism 0.3555066456481536 0.6116675018044927 0.5407577675207622 1.0 0.9079830728740496 29 P51648,Q9UKU0,O15254,P40939,P23786,Q16836 6 +Galactose metabolism 0.3978159491549056 0.5766607487112269 0.5641686527984047 1.0 0.9079830728740496 13 P16278,P52789,P06280 3 +Metabolism of xenobiotics by cytochrome p450 0.4400036753968085 0.5555018501273009 0.5785514449999214 1.0 0.9079830728740496 8 P78417,O14880,P07099,Q9Y2Q3,Q99735 5 +Peroxisome 0.3464340821188093 0.5508468844932553 0.5817386412395054 1.0 0.9079830728740496 33 P28288,Q9NR77,O15228,Q9BY49,O43808,P39210,O00116,P56589,Q9UKU0,O15254,P40855,O75381 12 +Abc transporters 0.4140323880298475 0.5034339640003401 0.6146591974910227 1.0 0.9079830728740496 9 Q03519,Q9NRK6,P28288,Q03518,Q9NP58,Q9NUT2 6 +Arrhythmogenic right ventricular cardiomyopathy arvc 0.3924488154618438 0.4997021277688601 0.6172848340374304 1.0 0.9079830728740496 12 P02545,P16615 2 +Primary bile acid biosynthesis 0.6707051879465635 0.4829759038452097 0.6291128455224406 1.0 0.9079830728740496 2 P51659 1 +Lysine degradation 0.3141635853439654 0.2800682974573923 0.779425106720673 1.0 0.948232823497652 26 O96028,P40939,P51648,Q16836 4 +Drug metabolism cytochrome p450 0.38794803204321 0.2503479724319614 0.802318260654221 1.0 0.949972529828682 7 Q9Y2Q3,P78417,Q99735,O14880 4 +Beta alanine metabolism 0.3495798451778162 0.2302445033335757 0.8179017819913856 1.0 0.9550982099383276 11 P51648 1 +Thyroid cancer 0.3628836500268944 0.1532005715232819 0.8782401069826975 1.0 0.9997576060620644 7 P04637 1 +Proteasome 0.2926305333083305 0.1152892102971369 0.9082158902717868 1.0 1.0 35 P28072,P61289,P49721,O00231 4 +Folate biosynthesis 0.3915311426537018 0.064800782641185 0.9483326183043908 1.0 1.0 4 P00374,Q92820 2 +Epithelial cell signaling in helicobacter pylori infection 0.2751319135129267 0.0014615876927266 0.9988338221609196 1.0 1.0 22 Q9Y487,Q93050 2 diff --git a/msigdb_kegg/selections.json b/msigdb_kegg/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..ab73e8aabb2e549c6710e00df57311bedc0efd89 --- /dev/null +++ b/msigdb_kegg/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["Abc transporters", "Acute myeloid leukemia", "Adherens junction", "Adipocytokine signaling pathway", "Alanine aspartate and glutamate metabolism", "Aldosterone regulated sodium reabsorption", "Allograft rejection", "Alpha linolenic acid metabolism", "Alzheimers disease", "Amino sugar and nucleotide sugar metabolism", "Aminoacyl trna biosynthesis", "Amyotrophic lateral sclerosis als", "Antigen processing and presentation", "Apoptosis", "Arachidonic acid metabolism", "Arginine and proline metabolism", "Arrhythmogenic right ventricular cardiomyopathy arvc", "Ascorbate and aldarate metabolism", "Autoimmune thyroid disease", "Axon guidance", "B cell receptor signaling pathway", "Basal cell carcinoma", "Basal transcription factors", "Base excision repair", "Beta alanine metabolism", "Biosynthesis of unsaturated fatty acids", "Bladder cancer", "Butanoate metabolism", "Calcium signaling pathway", "Cardiac muscle contraction", "Cell adhesion molecules cams", "Cell cycle", "Chemokine signaling pathway", "Chronic myeloid leukemia", "Citrate cycle tca cycle", "Colorectal cancer", "Cysteine and methionine metabolism", "Cytokine cytokine receptor interaction", "Cytosolic dna sensing pathway", "Dilated cardiomyopathy", "Dna replication", "Dorso ventral axis formation", "Drug metabolism cytochrome p450", "Drug metabolism other enzymes", "Ecm receptor interaction", "Endocytosis", "Endometrial cancer", "Epithelial cell signaling in helicobacter pylori infection", "Erbb signaling pathway", "Ether lipid metabolism", "Fatty acid metabolism", "Fc epsilon ri signaling pathway", "Fc gamma r mediated phagocytosis", "Focal adhesion", "Folate biosynthesis", "Fructose and mannose metabolism", "Galactose metabolism", "Gap junction", "Glioma", "Glutathione metabolism", "Glycerolipid metabolism", "Glycerophospholipid metabolism", "Glycine serine and threonine metabolism", "Glycolysis gluconeogenesis", "Glycosaminoglycan biosynthesis chondroitin sulfate", "Glycosaminoglycan biosynthesis heparan sulfate", "Glycosaminoglycan biosynthesis keratan sulfate", "Glycosaminoglycan degradation", "Glycosphingolipid biosynthesis ganglio series", "Glycosphingolipid biosynthesis globo series", "Glycosphingolipid biosynthesis lacto and neolacto series", "Glycosylphosphatidylinositol gpi anchor biosynthesis", "Glyoxylate and dicarboxylate metabolism", "Gnrh signaling pathway", "Graft versus host disease", "Hedgehog signaling pathway", "Hematopoietic cell lineage", "Histidine metabolism", "Homologous recombination", "Huntingtons disease", "Hypertrophic cardiomyopathy hcm", "Inositol phosphate metabolism", "Insulin signaling pathway", "Jak stat signaling pathway", "Leishmania infection", "Leukocyte transendothelial migration", "Limonene and pinene degradation", "Long term depression", "Long term potentiation", "Lysine degradation", "Lysosome", "Mapk signaling pathway", "Maturity onset diabetes of the young", "Melanogenesis", "Melanoma", "Metabolism of xenobiotics by cytochrome p450", "Mismatch repair", "Mtor signaling pathway", "N glycan biosynthesis", "Natural killer cell mediated cytotoxicity", "Neuroactive ligand receptor interaction", "Neurotrophin signaling pathway", "Nicotinate and nicotinamide metabolism", "Nitrogen metabolism", "Nod like receptor signaling pathway", "Non homologous end joining", "Non small cell lung cancer", "Notch signaling pathway", "Nucleotide excision repair", "O glycan biosynthesis", "Olfactory transduction", "One carbon pool by folate", "Oocyte meiosis", "Other glycan degradation", "Oxidative phosphorylation", "P53 signaling pathway", "Pancreatic cancer", "Pantothenate and coa biosynthesis", "Parkinsons disease", "Pathogenic escherichia coli infection", "Pathways in cancer", "Pentose and glucuronate interconversions", "Pentose phosphate pathway", "Peroxisome", "Phenylalanine metabolism", "Phosphatidylinositol signaling system", "Porphyrin and chlorophyll metabolism", "Ppar signaling pathway", "Primary bile acid biosynthesis", "Primary immunodeficiency", "Prion diseases", "Progesterone mediated oocyte maturation", "Propanoate metabolism", "Prostate cancer", "Proteasome", "Protein export", "Proximal tubule bicarbonate reclamation", "Purine metabolism", "Pyrimidine metabolism", "Pyruvate metabolism", "Regulation of actin cytoskeleton", "Regulation of autophagy", "Renal cell carcinoma", "Renin angiotensin system", "Retinol metabolism", "Riboflavin metabolism", "Ribosome", "Rig i like receptor signaling pathway", "Rna degradation", "Rna polymerase", "Selenoamino acid metabolism", "Small cell lung cancer", "Snare interactions in vesicular transport", "Sphingolipid metabolism", "Spliceosome", "Starch and sucrose metabolism", "Steroid biosynthesis", "Steroid hormone biosynthesis", "Sulfur metabolism", "Systemic lupus erythematosus", "T cell receptor signaling pathway", "Taste transduction", "Taurine and hypotaurine metabolism", "Terpenoid backbone biosynthesis", "Tgf beta signaling pathway", "Thyroid cancer", "Tight junction", "Toll like receptor signaling pathway", "Tryptophan metabolism", "Type i diabetes mellitus", "Type ii diabetes mellitus", "Tyrosine metabolism", "Ubiquitin mediated proteolysis", "Valine leucine and isoleucine biosynthesis", "Valine leucine and isoleucine degradation", "Vascular smooth muscle contraction", "Vasopressin regulated water reabsorption", "Vegf signaling pathway", "Vibrio cholerae infection", "Viral myocarditis", "Wnt signaling pathway"], "available_proteins": ["AARS", "AARS2", "AASDHPPT", "AASS", "ABCB1", "ABCB10", "ABCB6", "ABCB7", "ABCB8", "ABCC4", "ABCD3", "ACAA1", "ACAA2", "ACACA", "ACACB", "ACADM", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT7", "ACOT8", "ACOX1", "ACOX3", "ACP1", "ACP2", "ACP6", "ACSL1", "ACSL3", "ACSL4", "ACSL6", "ACTN1", "ACTN4", "ADA", "ADAR", "ADH5", "ADI1", "ADK", "ADSL", "ADSS", "AFDN", "AGK", "AGL", "AGPAT1", "AGPS", "AHCY", "AHCYL1", "AIFM1", "AK1", "AK2", "AK3", "AK4", "AKR1A1", "AKR1B1", "AKT2", "ALDH18A1", "ALDH1A2", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALG1", "ALG11", "ALG5", "ALYREF", "ANAPC1", "ANAPC2", "ANAPC4", "ANAPC5", "ANAPC7", "AP1B1", "AP1G1", "AP1M1", "AP1S1", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "APEX1", "APP", "APPL1", "APRT", "AQR", "ARF6", "ARFGAP1", "ARG2", "ARHGDIA", "ARHGEF2", "ARPC1A", "ARPC2", "ARPC3", "ARPC4", "ASAH1", "ASNA1", "ASNS", "ATG3", "ATIC", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP2B4", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1D", "ATP6V1E1", "ATP6V1H", "AURKA", "B3GALT6", "B4GAT1", "BAIAP2", "BCAS2", "BCR", "BIRC6", "BLM", "BLVRA", "BNIP1", "BPNT1", "BRCA1", "BUB1B", "BUB3", "BUD23", "BUD31", "CAB39", "CACYBP", "CAD", "CALD1", "CALR", "CAMK2G", "CANT1", "CANX", "CAPN1", "CAPN2", "CARS", "CASK", "CBR1", "CCDC6", "CCNB1", "CD47", "CDC16", "CDC23", "CDC27", "CDC42", "CDC5L", "CDH2", "CDIPT", "CDK1", "CDK2", "CDK4", "CDK5", "CDK6", "CDKN2A", "CDS2", "CETN2", "CFL1", "CFL2", "CHD8", "CHDH", "CHERP", "CHKA", "CHMP2B", "CHMP3", "CHMP4B", "CHMP5", "CHORDC1", "CHST14", "CKB", "CKMT1A*", "CLN5", "CLTA", "CLTB", "CLTC", "CMAS", "CMPK1", "CNOT1", "CNOT4", "CNOT9", "COMT", "COX15", "COX2", "COX4I1", "COX5A", "COX5B", "COX6C", "COX7A2", "COX7A2L", "CPOX", "CPT1A", "CPT2", "CRK", "CRKL", "CRNKL1", "CS", "CSGALNACT2", "CSK", "CSNK1A1", "CSNK2A1", "CSNK2A2", "CSNK2B", "CTBP1", "CTBP2", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTPS2", "CTSA", "CTSC", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4A", "CUL4B", "CUL5", "CWC15", "CXADR", "CYB5R1", "CYB5R3", "CYC1", "CYFIP1", "CYFIP2", "CYP51A1", "DARS", "DARS2", "DBT", "DCP1B", "DCPS", "DCTD", "DCTN1", "DCTN2", "DCTN4", "DCXR", "DDB1", "DDOST", "DDX23", "DDX39B", "DDX3X", "DDX42", "DDX46", "DDX5", "DDX6", "DERL1", "DFFA", "DHCR24", "DHCR7", "DHFR", "DHX15", "DHX16", "DHX38", "DHX8", "DIAPH1", "DIAPH2", "DIAPH3", "DIS3", "DLAT", "DLD", "DLG1", "DLST", "DNA2", "DNM1L", "DNM2", "DNMT1", "DOLPP1", "DPM1", "DPYSL2", "DPYSL5", "DSG2", "DSP", "DTX3L", "DTYMK", "DUSP3", "DUSP9", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNC2H1", "DYNLL1", "DYNLL2", "EARS2", "EBP", "ECH1", "ECHS1", "ECI1", "ECI2", "ECSIT", "EDC3", "EDC4", "EEA1", "EFTUD2", "EHD1", "EHD4", "EI24", "EIF4A3", "EIF4B", "EIF4E", "EIF4E2", "EIF4G1", "EIF4G2", "EIF4G3", "ELOB", "EMD", "ENAH", "ENDOD1", "ENO1", "ENO2", "EPB41", "EPB41L2", "EPB41L3", "EPHA7", "EPHX1", "EPHX2", "EPN1", "EPRS", "ERBIN", "ERCC2", "ERCC3", "ERO1A", "EXO1", "EXOC3", "EXOC7", "EXOSC1", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC8", "EXOSC9", "EZR", "F11R", "FADS2", "FAH", "FAR1", "FARP2", "FARSA", "FARSB", "FASN", "FAU", "FDFT1", "FDPS", "FECH", "FEN1", "FH", "FLAD1", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FUCA1", "FUCA2", "G6PD", "GAA", "GABARAPL2", "GALK1", "GALM", "GALNS", "GALNT1", "GALNT2", "GALNT4", "GALNT7", "GANAB", "GAPDH", "GARS", "GART", "GBA", "GCAT", "GCDH", "GCLC", "GFPT1", "GGA1", "GGCT", "GGH", "GGT7", "GLA", "GLB1", "GLCE", "GLDC", "GLG1", "GLO1", "GLS", "GLUD1", "GM2A", "GMPS", "GNA13", "GNAI1", "GNAI2", "GNAI3", "GNAQ", "GNE", "GNG12", "GNG5", "GNPAT", "GNPDA1", "GNPNAT1", "GNS", "GOSR1", "GOT1", "GOT2", "GPAA1", "GPAM", "GPAT4", "GPD1L", "GPD2", "GPI", "GPT2", "GRB2", "GRHPR", "GSK3B", "GSR", "GSS", "GSTK1", "GSTM3", "GSTO1", "GSTZ1", "GTF2E1", "GTF2E2", "GTF2F1", "GTF2H1", "GTF2H4", "GTF2I", "GYS1", "H2AFY", "H2AFY2", "H4C1*", "HACL1", "HADH", "HADHA", "HADHB", "HARS2", "HCCS", "HDAC1", "HDAC2", "HEXA", "HEXB", "HGS", "HIBADH", "HIBCH", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HMBS", "HMGB1", "HMGCL", "HMGCR", "HMGCS1", "HMMR", "HMOX1", "HMOX2", "HNRNPA1", "HNRNPA3", "HNRNPC", "HNRNPK", "HNRNPM", "HNRNPU", "HPRT1", "HS2ST1", "HSD17B10", "HSD17B12", "HSD17B4", "HSD17B7", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA1B", "HSPA2", "HSPA4", "HSPA8", "HSPA9", "HSPD1", "HTT", "HUWE1", "IARS", "IARS2", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDH3G", "IDI1", "IGF2BP1", "IGF2R", "IKBKB", "ILK", "IMPDH1", "IMPDH2", "INPP4A", "INPPL1", "IQGAP1", "IQGAP3", "IRS4", "ISY1", "ISYNA1", "ITCH", "ITGB1", "ITPA", "ITPK1", "IVD", "JUP", "KARS", "KDELR1", "KDSR", "KIDINS220", "L2HGDH", "LAMB1", "LAMC1", "LAMP1", "LAMP2", "LAP3", "LARS", "LARS2", "LCLAT1", "LDHA", "LDHB", "LDLR", "LGMN", "LIG1", "LIG3", "LIPA", "LLGL1", "LMNA", "LNPEP", "LPCAT1", "LPGAT1", "LRP1", "LSM2", "LSM4", "LSM6", "LSM7", "LSS", "LTA4H", "LYN", "LYPLA1", "M6PR", "MALT1", "MAN2A1", "MAN2B1", "MAPK1", "MAPK14", "MARS", "MARS2", "MAT2A", "MAT2B", "MAVS", "MBOAT7", "MCCC1", "MCCC2", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MDH1", "MDH2", "ME1", "ME2", "MGST2", "MGST3", "MIF", "MINPP1", "MMAB", "MOGS", "MPG", "MPHOSPH6", "MPI", "MPST", "MPV17", "MRE11", "MSH2", "MSH3", "MSH6", "MSMO1", "MSN", "MTAP", "MTCH1", "MTHFD1", "MTHFD1L", "MTHFD2", "MTHFS", "MTMR2", "MTMR6", "MTOR", "MTR", "MUT", "MVD", "MYH10", "MYH14", "MYH9", "MYL6", "NAE1", "NAGLU", "NAMPT", "NANS", "NARS", "NBN", "NCBP1", "NCKAP1", "NCL", "NCSTN", "ND1", "NDUFA10", "NDUFA11", "NDUFA4", "NDUFA5", "NDUFA7", "NDUFA8", "NDUFA9", "NDUFB10", "NDUFB3", "NDUFB4", "NDUFB5", "NDUFB6", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS6", "NDUFS7", "NDUFS8", "NDUFV1", "NDUFV2", "NEDD4L", "NEFL", "NEFM", "NF1", "NIT2", "NLN", "NLRX1", "NME1", "NME2", "NNT", "NOTCH2", "NPC1", "NPC2", "NRP1", "NSD1", "NSD2", "NSD3", "NSDHL", "NSF", "NT5C2", "NT5C3A", "NTHL1", "NUDT5", "OAT", "OCLN", "OCRL", "OGDH", "ORC2", "ORC3", "ORC5", "OXA1L", "P4HA1", "P4HA2", "PAFAH1B1", "PAFAH1B2", "PAFAH1B3", "PAICS", "PAK2", "PANK4", "PAPOLA", "PAPSS1", "PARD3", "PARK7", "PARN", "PARP1", "PARP2", "PATL1", "PC", "PCBP1", "PCCA", "PCCB", "PCNA", "PDCD6", "PDCD6IP", "PDHA1", "PDHB", "PDHX", "PDIA3", "PDIA4", "PDSS2", "PECR", "PEX11B", "PEX14", "PEX19", "PEX3", "PFAS", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGM3", "PGP", "PHF5A", "PHGDH", "PHKA1", "PHKB", "PI4KA", "PI4KB", "PIGG", "PIGK", "PIGS", "PIGT", "PIGU", "PIK3C2A", "PIK3R2", "PIK3R4", "PIN1", "PIP4K2C", "PISD", "PKM", "PKMYT1", "PKN1", "PLA2G15", "PLCG1", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLRG1", "PLXNB2", "PMPCA", "PMVK", "PNP", "PNPT1", "POLA1", "POLA2", "POLD1", "POLD2", "POLDIP2", "POLE", "POLE2", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2A", "POLR2B", "POLR2C", "POLR2D", "POLR2E", "POLR2G", "POLR2L", "POLR3A", "POLR3B", "POLR3C", "PPA1", "PPA2", "PPAT", "PPCDC", "PPID", "PPIE", "PPIH", "PPOX", "PPP1CA", "PPP1CB", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP2R5E", "PPP3CA", "PPP5C", "PPT1", "PQBP1", "PRDX5", "PRDX6", "PRIM1", "PRIM2", "PRKAA1", "PRKAA2", "PRKACA", "PRKAG1", "PRKAR1A", "PRKAR2A", "PRKCB", "PRKDC", "PRPF19", "PRPF3", "PRPF31", "PRPF38B", "PRPF4", "PRPF40A", "PRPF6", "PRPF8", "PRPS2", "PSAP", "PSAT1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD11", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD6", "PSMD7", "PSMD8", "PSME1", "PSME2", "PSME3", "PSME4", "PTDSS1", "PTDSS2", "PTGES2", "PTK2", "PTPN1", "PTPN11", "PTPRF", "PUF60", "PXMP2", "PXN", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QDPR", "RAB13", "RAB23", "RAB3B", "RAB5A", "RAB5B", "RAB5C", "RAC1", "RAD21", "RAD23A", "RAD23B", "RAD50", "RALA", "RAPGEF2", "RARS", "RARS2", "RBM17", "RBM22", "RBM25", "RBM8A", "RBMX", "RBPJ", "RDH11", "RDX", "RETSAT", "REXO2", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RFT1", "RHEB", "RIPK1", "RNASEH2A", "ROBO1", "ROCK1", "ROCK2", "RPA1", "RPA2", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPN1", "RPN2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS26", "RPS28", "RPS29", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RPTOR", "RRAS2", "RRM1", "RRM2", "RSL24D1", "RUFY1", "RUVBL1", "SAE1", "SARS", "SARS2", "SART1", "SCARB2", "SCD", "SCP2", "SDHA", "SDHB", "SDHC", "SEC11A", "SEC22B", "SEC61A1", "SEC61B", "SEC62", "SEC63", "SETD1A", "SETD2", "SETDB1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", 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0.0004274197333293 7.514563106796117 15.521844660194176 0.6340330218232789 0.1371235236408302 2.3948329397108954 1.2175929202976112 2.2116324239586063 0.2290247571497847 3.0431154055049713e-09 0.0108643857486399 1.4194050004739812e-05 8.44295788022346e-07 2.0945394143108066e-08 +Mitochondrial protein import 21 33 3.435396008607837 0.0005916885018668 13.468446601941748 34.5873786407767 1.6025718162972953 0.1874419874946837 6.078090089851624 2.2108812815475147 1.8878681708577505 0.2901223460226844 1.0355378100629647e-10 0.0001764406413441 0.0002457945313068 7.846229983304866e-05 1.733958957496337e-12 +Cristae formation 11 20 3.336604913900564 0.0008480841293909 8.475728155339805 19.805825242718445 0.8613288847471563 0.2756396593916832 3.7825471979528897 1.2052333490949263 1.5890526548766304 0.3070386069824295 1.864926703735148e-10 0.0073558029266518 0.0021303683071518 3.588913913812074e-05 1.341131808798661e-09 +Respiratory electron transport 24 54 3.2442085807930066 0.0011777746614829 17.473300970873787 52.5752427184466 0.7619430018929745 0.3962973483509951 7.757662405441163 5.39117119769307 1.7039672197087123 0.3858226471737118 3.010663914053486e-06 0.0013653653935254 5.291381360115776e-06 0.000724477579467 3.082292121275278e-07 +Glycerophospholipid biosynthesis 15 33 3.22784561141403 0.0012472627066391 9.439320388349516 29.58009708737864 1.1800609247564997 0.3081196451067344 4.809346434845489 4.094857299253986 1.3402414818469337 0.3224557628717913 9.038743878269184e-06 1.0 1.0 0.0002181683579302 3.0909448345257607e-06 +Ion channel transport 18 31 3.034380474874664 0.0024103024262827 9.031553398058252 27.74271844660194 0.8980727715308076 0.3472480807052641 4.2752930421976005 3.4432740668393595 1.4212023690700646 0.3452897078102002 9.401056443443824e-07 0.3274019772455256 0.1862598674919939 2.5917903680851456e-05 7.80218620903672e-06 +Glycosaminoglycan metabolism 12 16 2.9211174966304543 0.0034877826308521 6.563106796116505 14.388349514563108 0.750167459040055 0.1742505874253542 2.387954817808654 2.3973407990867264 1.8682770414846892 0.2409021330213527 0.002088101944128 0.2870659866655126 0.4925597827158772 0.0266777247012389 0.006476918487605 +Sphingolipid de novo biosynthesis 4 11 2.8360364487787257 0.0045677232769563 4.08252427184466 10.614077669902912 1.3205451179619188 0.2079933246203462 1.939118365602947 1.3614298144224892 1.289169434780902 0.261809046515659 0.0058884014663197 1.0 0.031373049189738 0.0048864602536943 0.0119362160344991 +Slc mediated transmembrane transport 11 19 2.788327982018972 0.0052980875460379 8.672330097087379 21.910194174757283 1.4735742044813558 0.239038892478899 4.348519601656105 3.146764860695784 1.3934177975338422 0.3068823132077037 0.0222387830330423 1.0 0.2533609509960167 0.0352078323408286 0.024491814988438 +Mitophagy 6 13 2.691488910385353 0.0071133863215644 3.662621359223301 11.783980582524272 1.3564301304992197 0.1917930287367771 1.8155907654273165 1.3363606860118669 1.2723890100166135 0.2636913304405313 0.0153022136017921 0.0058373227860703 0.0015052123544451 0.0024022577840735 0.0001024209024739 +Mitochondrial calcium ion transport 13 16 2.6831268815635 0.0072937312468108 6.502427184466019 16.12135922330097 1.0650233237312683 0.2089377868120644 3.410790121717641 1.246287729205551 1.626144580445205 0.28031724173526 0.0001450821031219 0.0963063052639835 4.236608354872846e-05 0.0001164002838048 3.907616018373289e-05 +The citric acid tca cycle and respiratory electron transport 35 97 2.670621347577161 0.0075710999986131 27.99757281553398 94.17961165048544 0.4883573568636233 0.4259472248586306 12.60942373482268 7.020896123249261 1.7895370613076145 0.38969273744301 1.381679678895206e-09 0.0009764000932441 3.7384059203535626e-08 0.0001289352960615 5.857555286089111e-10 +Pink1 prkn mediated mitophagy 6 8 2.639411523603305 0.0083050098387371 3.2815533980582523 8.473300970873787 1.395617281862234 0.1554977461962819 1.6230588150315317 0.9738153254376878 1.3577427922485954 0.2414588001366878 0.0042940863146269 0.0029386578360865 0.0005309775927247 0.0006143549700213 7.746328029618005e-06 +Stimuli sensing channels 5 10 2.600365429748465 0.0093124535201265 3.075242718446602 8.648058252427184 0.6737384899082146 0.3285895756392196 1.7754169999219978 1.9694070657894505 1.2463928142905627 0.307032431313504 0.0040997845467264 0.1675604235637086 0.3076603852203092 0.002055769463525 0.0093317531476842 +Class i peroxisomal membrane protein import 10 12 2.596084431886052 0.0094292891471807 4.300970873786408 9.604368932038836 1.1426576411245968 0.2560233101944223 2.515331441636984 1.9424437465598188 1.2133199793435778 0.2911424942178205 0.0008071226260475 1.0 0.1677870330809631 0.0101015401572799 0.0017429018144962 +Insertion of tail anchored proteins into the endoplasmic reticulum membrane 5 10 2.576915173550557 0.0099686410799388 4.016990291262136 10.99757281553398 1.1239772251284714 0.2752182956921286 1.9514004604865949 1.181365809872934 1.0815649178051203 0.2865915409883788 7.777719939590686e-05 0.0875404472016038 0.014058804472369 0.0757571260003459 0.000200465132953 +Metabolism of porphyrins 3 9 2.5711484220138394 0.0101361875596388 2.766990291262136 9.186893203883496 1.2638611374915407 0.2204767139400954 1.3861582272503026 1.170645435718008 1.0950295956895657 0.2541910601955712 0.0042940863146269 0.0029386578360865 0.0113213926532688 0.0006143549700213 0.0078812527225172 +Phospholipid metabolism 17 54 2.515313415143393 0.0118926608623124 12.859223300970871 45.932038834951456 1.017004520648936 0.3949296504793965 6.241466981115118 7.362344677079641 1.3242274243570669 0.3709328103546776 0.0017949525069594 1.0 1.0 0.0132467171015694 0.0005499292692006 +Ion transport by p type atpases 8 12 2.515137612949188 0.011898593022497 3.7305825242718447 10.33980582524272 0.407323607098393 0.3519804201795568 2.374569281431047 1.6883576098110384 1.2891970822622851 0.3108388098264688 0.0013915714203141 1.0 0.2590666885683055 0.0379489226270714 0.0033138804057902 +Transport of small molecules 79 157 2.450421877323298 0.0142688922582365 41.730582524271846 151.96601941747574 1.4265613612661356 0.380396759556163 14.87709311863932 12.598305121005488 1.746958952072276 0.4128488770716938 1.9340185729348428e-11 0.1064647583825767 0.0002522594661127 1.867204960584538e-09 1.546940394944186e-12 +Cholesterol biosynthesis 7 18 2.4279955757739224 0.0151825284819588 5.878640776699029 16.75 1.3996798653689082 0.2350718901934974 2.503362805703168 1.8986773628384943 1.0886216368414 0.270950573691616 3.022212417676795e-06 0.1093006244161378 0.0219975904219434 5.3982024224599555e-08 9.47697315695096e-07 +Ire1alpha activates chaperones 5 22 2.3954256640511566 0.0166010800947085 6.050970873786408 24.223300970873787 0.9379365742980283 0.4047880585679882 2.6930013625985207 2.1985522104416564 1.0262193137091864 0.3353529084578252 0.0085357436861326 0.0188245552589776 0.0085749794431607 0.0039562767661884 0.0187017730028202 +Mitochondrial biogenesis 11 34 2.324682499151915 0.0200889437591915 10.572815533980584 33.521844660194176 0.7125383902440768 0.3998427377933914 4.798567629623383 2.9315837025395943 1.2191838320541302 0.3355715376706868 0.000163904094561 0.0627750690965546 0.0483217377147592 0.0166326939811153 0.0007767330813302 +Gpcr ligand binding 4 10 2.2870175270481403 0.0221948000843628 3.4611650485436893 9.330097087378642 1.051447004644797 0.2131328881138611 1.5951828582954857 1.3192992367203638 1.3003237502897853 0.2397874119507845 0.1176699879287588 0.1991580424676108 0.3593428278464597 0.0989248704147511 0.0707827064406983 +Depolymerisation of the nuclear lamina 3 9 2.273982323859455 0.0229670493232969 3.5509708737864076 9.264563106796116 0.3528590781344482 0.4868013249239434 1.8459675362212444 0.9401541669683848 0.9887999500170416 0.3159648114925705 0.0033918567435536 1.0 0.1432798584585485 0.0557098434243155 0.0062633876942655 +Formation of atp by chemiosmotic coupling 3 9 2.2049374196520213 0.0274584862328892 3.5898058252427183 9.805825242718448 0.4783111855246443 0.2899716869602585 2.2195497140568734 0.9063771094889388 1.382334358445268 0.2713732710506487 0.0019907060593634 0.0652597674910206 0.0077184558590264 0.0435926191526008 0.003721367796782 +Synthesis of pa 5 12 2.195084841811769 0.0281575123472039 2.9635922330097086 8.558252427184467 0.9129149199765416 0.2964837496518883 1.9473992387004595 1.904008254033093 1.1909456358572703 0.2923824193190221 0.0030125175996134 1.0 1.0 0.0028063338575205 0.0010205277760807 +Synthesis of very long chain fatty acyl coas 3 8 2.172541686880218 0.0298148288581254 3.0800970873786406 7.662621359223301 0.2970725454313344 0.3790733377388842 1.7392923430670622 0.9085681268331954 1.2502564772465108 0.3141166423632316 0.0042940863146269 1.0 1.0 0.0621585272883563 0.0078812527225172 +Regulation of insulin like growth factor igf transport and uptake by insulin like growth factor binding proteins igfbps 6 18 2.171994610500565 0.0298560694357403 6.014563106796117 17.274271844660195 0.870961683103299 0.329566970411291 2.8591161566949044 2.4465188670593117 1.2657234914365352 0.3108311955329007 0.0074782494064358 0.2370066357192962 0.1009015630926116 0.0110236812642753 0.0180126260897142 +Peptide ligand binding receptors 3 7 2.1619766066694224 0.03061997939239 2.8640776699029127 6.796116504854369 1.193322814833652 0.1851946070449122 1.2850789986620814 0.7987760455175396 1.3206182868906609 0.2426624676455473 0.0042940863146269 0.0786913117950012 0.1515272625734178 0.0073447144383531 0.0078812527225172 +Class a 1 rhodopsin like receptors 3 7 2.1619766066694224 0.03061997939239 2.8640776699029127 6.796116504854369 1.193322814833652 0.1851946070449122 1.2850789986620814 0.7987760455175396 1.3206182868906609 0.2426624676455473 0.0094903075706385 0.0963063052639835 0.1837383274168749 0.0133829456596615 0.017002584405276 +Initiation of nuclear envelope ne reformation 5 15 2.123926479041827 0.0336762918341604 5.029126213592233 17.313106796116504 0.6703973563590633 0.4764668209175622 2.443363552582699 1.0411546326925285 0.8298821064609638 0.3128165384367375 0.0010403956302503 1.0 0.1758008751515455 0.0116756742779249 0.00223229240551 +Intra golgi traffic 6 16 2.1197339764124457 0.0340284859804371 4.424757281553398 13.87135922330097 0.7636302424906817 0.4243971711811651 2.688824171738392 3.845367291797066 0.9598354803720488 0.3140361333882177 0.5173032113733875 1.0 0.3339976348230559 0.2691814013824262 0.3340933889960909 +Processing of smdt1 9 11 2.1042442986323557 0.0353571421537715 4.975728155339806 11.155339805825244 0.3833102568885913 0.3649000478471426 2.609615007852169 1.2287595888742628 1.3301610577177632 0.3259664414506655 0.1374503862977756 1.0 1.0 0.3236592382947187 0.0397387250697101 +Cytoprotection by hmox1 12 62 2.0924563074694107 0.0363977163457911 15.264563106796116 64.83495145631068 0.939000341067099 0.4699320360831873 6.884300879212943 3.5957015529431366 1.0482386655891682 0.3835416044430508 0.0017475558589878 0.0978430492695897 0.004090384648508 0.0050626873693417 0.002527852573753 +N glycan trimming in the er and calnexin calreticulin cycle 5 16 2.0802459194730187 0.0375029823746073 4.878640776699029 14.699029126213592 0.108355189317792 0.5779465857553798 2.939491749392236 1.3189062212723417 0.9052506944453566 0.3169163043543442 0.0090332289343176 1.0 0.266209970857853 0.0411512789917762 0.003914644875648 +Rhoa gtpase cycle 18 47 2.0631091414309246 0.0391022598472303 11.383495145631068 46.157766990291265 0.7285935948010234 0.4866370775942555 5.135874153241841 5.803151375541917 0.959659542192298 0.3649179877597411 0.0478794962409839 0.1354750356227081 0.3700525131557232 0.1053216544744746 0.0610477161186252 +Heparan sulfate heparin hs gag metabolism 4 5 2.05314572917958 0.0400584460329971 2.4320388349514563 4.83252427184466 0.8003221575390526 0.2230961855611341 1.2648123228701085 1.2708877857521428 1.4628061886044337 0.2633127679646707 0.1412206545018741 1.0 1.0 0.1800390494619342 0.2015708610705285 +Chondroitin sulfate dermatan sulfate metabolism 3 5 2.02160015106976 0.0432176764493217 1.7936893203883495 4.021844660194175 0.1833102203803382 0.2980238462552717 1.0674618205957698 1.1286251173357766 1.5088456365203304 0.2864106402914596 0.1412206545018741 0.1430638950507344 0.266209970857853 0.1800390494619342 0.2015708610705285 +Selective autophagy 7 32 2.0104695205363208 0.0443815189736502 7.315533980582524 31.50728155339806 0.9304065525388932 0.4028226131520862 3.350474746292583 3.101431769008479 1.074438805028982 0.3502038092942861 0.1384351962571886 0.0410390344011431 0.0264876267470493 0.0225481074784796 0.0153483993146073 +Complex i biogenesis 10 29 1.9873567316592349 0.0468828789519955 9.1747572815534 28.546116504854368 0.5440760559261008 0.4236381582634617 4.289696810672699 3.852285850983641 1.2631239118061712 0.3404380044043241 0.0074782494064358 0.0295498589150116 0.002010543955723 0.0457432535763689 0.0013733005063119 +Transport of vitamins nucleosides and related molecules 5 8 1.9872975245077027 0.046889435842147 3.2985436893203883 7.703883495145631 0.5884630304197642 0.3368828823659784 1.766928610360549 0.9135891377639136 1.2550983698791685 0.3076045725047946 0.0094903075706385 1.0 1.0 0.0901924811619011 0.017002584405276 diff --git a/msigdb_reactome/metrics.json b/msigdb_reactome/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..c3dc3ad74dc9ff658551f040e97493086039568c --- /dev/null +++ b/msigdb_reactome/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3221, + "annotations_size": 1391, + "title": "Average number of proteins per term", + "value": 19.46728971962617 +} \ No newline at end of file diff --git a/msigdb_reactome/paths.json b/msigdb_reactome/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..83d32d6f0fcb2f7ecbcc07ed600f15c309f65226 --- /dev/null +++ b/msigdb_reactome/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/msigdb_reactome/fragment/C201/C201_val_log2fc"} \ No newline at end of file diff --git a/msigdb_reactome/result.tsv b/msigdb_reactome/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..8ac278d111b9bdfcf23785973791daf18bb1f8df --- /dev/null +++ b/msigdb_reactome/result.tsv @@ -0,0 +1,362 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Protein localization 0.6280618025837502 4.134001497483836 3.5650114864616e-05 0.0483806758306958 0.043497642270219 73 P06576,P46379,Q8N4H5,O43681,Q9Y3D6,Q9NS69,O43615,P56589,Q10713,P40855,Q5T8D3,O60830,O14925,Q5JRX3,P09601,P28288,P50402,Q9Y5J9,P08574,Q9BY49,Q9Y512,Q13505,P05067,P21796,P39210,P51648,O96008,P14735,Q7L5D6,Q9Y5J6,Q9NR77,Q8TB36,Q15388,Q9NX63,O75431,P12236,Q9UJS0,O75746,O43808,O00116,O15254,O15228,P12235,Q3ZCQ8,O75381 45 +Sphingolipid metabolism 0.826352388193725 4.003010438037494 6.254154172569137e-05 0.0833210756524068 0.043497642270219 28 P16278,P07602,Q16739,O43681,P17900,Q9NZJ7,Q16880,P04062,Q13510,Q96G23,O15269,P51648,P10619,O95470,Q06136 15 +Respiratory electron transport atp synthesis by chemiosmotic coupling and heat production by uncoupling proteins 0.6052040129634736 3.8730409396761 0.0001074857637113 0.1388794159003227 0.0498375657741559 63 O14949,Q9P0J0,Q9BQ95,P06576,P20674,P56385,Q9UDW1,O43819,P22695,P03886,O43676,O95139,O14548,P24539,P08574,P00403,Q99643,Q86Y39,Q8N8Q8,P13073,O95168,O95299,O96000,O75964,Q9Y6M9,P21912,O75880,P51970 28 +Glycosphingolipid metabolism 0.8413337838220211 3.5225479388484775 0.0004274197333293 0.4482542543502703 0.0823038706096804 17 P16278,P07602,Q16739,P17900,O43681,Q9NZJ7,P06280,P04062,Q16880,Q13510,P10619 11 +Mitochondrial protein import 0.717397465551409 3.435396008607837 0.0005916885018668 0.5610116015408413 0.0823038706096804 33 P06576,Q8N4H5,O43615,Q9NS69,Q10713,O60830,O14925,Q5JRX3,Q9Y5J9,Q9Y512,Q13505,P21796,O96008,Q9Y5J6,Q15388,Q9NX63,O75431,P12236,Q9UJS0,O75746,P12235 21 +Cristae formation 0.7713152229893352 3.336604913900564 0.0008480841293909 0.6927782695487266 0.0907450018448338 20 P06576,Q5XKP0,P24539,Q9Y512,Q13505,Q16891,Q9BUR5,Q6UXV4,O75964,Q9NX63,O75431 11 +Respiratory electron transport 0.5930864343071054 3.2442085807930066 0.0011777746614829 0.8058744331181675 0.1084339015584374 54 O14949,Q9P0J0,Q9BQ95,P20674,Q9UDW1,O43819,P22695,P03886,O43676,O95139,O14548,P08574,P00403,Q99643,Q86Y39,Q8N8Q8,P13073,O95168,O95299,O96000,Q9Y6M9,P21912,O75880,P51970 24 +Glycerophospholipid biosynthesis 0.6866868007797177 3.22784561141403 0.0012472627066391 0.8237805683771169 0.1084339015584374 33 O95674,Q9UG56,Q8N2A8,P35790,Q9HCL2,Q96N66,Q9NPH0,Q8NAN2,Q9NUQ2,Q8IV08,Q53H12,P40939,Q9BVG9,Q92604,Q8NF37 15 +Ion channel transport 0.6649176467985758 3.034380474874664 0.0024103024262827 0.9651526340380856 0.1862628152755136 31 Q04656,Q96PU5,P98194,Q93050,Q9C0H2,P23634,Q15904,Q9HD20,Q9NW15,P20020,Q9Y487,Q4KMQ2,P27105,P05023,P51790,P51798,P35670,P16615 18 +Glycosaminoglycan metabolism 0.7436190015811448 2.9211174966304543 0.0034877826308521 0.9922494065311545 0.2205229836143332 16 P16278,P34059,Q8N6G5,Q8NCH0,Q8TB61,P54802,Q96L58,Q7LGA3,O43252,P06865,O75330,O94923 12 +Sphingolipid de novo biosynthesis 0.8162500265502037 2.8360364487787257 0.0045677232769563 0.9982848562746272 0.2762479599237493 11 Q06136,O95470,Q96G23,P51648 4 +Slc mediated transmembrane transport 0.6908792526261515 2.7883279820189717 0.0052980875460379 0.9993821293982206 0.2947855910615544 19 O00400,P12236,Q70HW3,P05141,Q8TB61,Q9UBX3,P04920,Q15043,P30825,P12235,P35613 11 +Mitophagy 0.7507059252490635 2.691488910385353 0.0071133863215644 0.9999513121304868 0.2974492551888003 13 Q8IWA4,Q8N4H5,Q15388,Q9NS69,P21796,O96008 6 +Mitochondrial calcium ion transport 0.7023831676954682 2.6831268815634997 0.0072937312468108 0.999962183333194 0.2974492551888003 16 Q8NE86,Q9UJZ1,Q99623,Q9Y277,P45880,Q9Y4W6,Q8WWC4,Q9BPX6,P21796,Q10713,Q96TA2,P35232,O95202 13 +The citric acid tca cycle and respiratory electron transport 0.5053880940285803 2.670621347577161 0.0075710999986131 0.9999743628891778 0.2974492551888003 97 O14949,Q9P0J0,Q9BQ95,P06576,P20674,Q9H9P8,P56385,Q9UDW1,P09622,O43819,P03886,P22695,O43676,O95139,O14548,P24539,P08574,P00403,Q99643,P21796,Q86Y39,Q13423,P48163,Q8N8Q8,P13073,O95168,O95299,O96000,O75964,Q9Y6M9,P21912,O75880,Q9P0J1,P51970,P35613 35 +Pink1 prkn mediated mitophagy 0.8485525693346558 2.639411523603305 0.0083050098387371 0.9999908385564836 0.2974492551888003 8 Q8IWA4,Q8N4H5,Q15388,Q9NS69,P21796,O96008 6 +Stimuli sensing channels 0.7876039595556955 2.600365429748465 0.0093124535201265 0.9999977717965848 0.2974492551888003 10 Q96PU5,Q9C0H2,P27105,P51798,P51790 5 +Class i peroxisomal membrane protein import 0.7509593964213943 2.5960844318860516 0.0094292891471807 0.9999981089354676 0.2974492551888003 12 P28288,Q9NR77,Q8TB36,O43808,Q9Y3D6,P51648,P56589,P40855,O75381,Q5T8D3 10 +Insertion of tail anchored proteins into the endoplasmic reticulum membrane 0.7829335201152491 2.5769151735505575 0.0099686410799388 0.9999991134754368 0.2974492551888003 10 P09601,O43681,P50402,P05067,P51648 5 +Metabolism of porphyrins 0.7990328973137114 2.5711484220138394 0.0101361875596388 0.999999299436436 0.2974492551888003 9 P30519,P09601,Q7KZN9 3 +Phospholipid metabolism 0.5110883962287827 2.515313415143393 0.0118926608623124 0.9999999407705232 0.2974492551888003 54 O95674,Q9UG56,Q8N2A8,P35790,Q9HCL2,Q96N66,Q9NPH0,Q8NAN2,Q9NUQ2,Q8IV08,Q53H12,Q10713,P48651,P40939,Q9BVG9,Q92604,Q8NF37 17 +Ion transport by p type atpases 0.7357841151339829 2.515137612949188 0.011898593022497 0.9999999412630874 0.2974492551888003 12 P98194,P23634,Q9HD20,P20020,P05023,P16615,P35670,Q04656 8 +Transport of small molecules 0.5408338117026533 2.450421877323298 0.0142688922582365 0.9999999979202028 0.2974492551888003 157 Q9C0H2,P05141,P20020,P55011,Q4KMQ2,Q8TDW0,P09601,Q9NRK6,P30519,P23634,P45880,Q6PIU2,P21796,Q13616,P35670,O15118,O95202,Q70HW3,Q9Y277,P30825,P49721,P54709,Q93050,Q9UBX3,Q9HD20,Q9UEY8,Q9Y487,O00400,Q8NE86,Q9Y289,P56589,P40855,Q96TA2,Q9UBV2,Q9GZP9,P16615,Q8WTV0,Q96PU5,P28288,O75477,Q8TB61,P27105,P51798,Q99623,P61421,P53985,P36543,Q15043,Q8WWC4,P28070,P51790,O00231,Q9UJZ1,P28072,P07237,O75027,P35613,P61289,Q99797,Q9NW15,Q10713,P05023,P98194,Q04656,P61916,P12236,Q15904,Q9NUT2,Q9NP58,P12235,Q9BU23,P10644,Q9BUN8,Q9UL46,P63218,Q9BPX6,P04920,O94905,P35232 79 +Cholesterol biosynthesis 0.6422765360942702 2.4279955757739224 0.0151825284819588 0.9999999994274136 0.2974492551888003 18 Q15392,P37268,Q14534,Q15800,Q16850,Q15125,Q14739 7 +Ire1alpha activates chaperones 0.6001452238948847 2.3954256640511566 0.0166010800947085 0.9999999999229008 0.3086528593587077 22 O95070,P02545,P43307,Q9Y5M8,O76024 5 +Mitochondrial biogenesis 0.5590461229276255 2.324682499151915 0.0200889437591915 0.9999999999994496 0.3211921927475342 34 P06576,Q5XKP0,P24539,Q9Y512,Q13505,Q16891,Q9BUR5,Q6UXV4,O75964,Q9NX63,O75431 11 +Gpcr ligand binding 0.7262895890203749 2.2870175270481403 0.0221948000843628 0.9999999999999724 0.3480522973668806 10 P42892,P07602,Q9NZJ7,P05067 4 +Depolymerisation of the nuclear lamina 0.739455699757651 2.273982323859455 0.0229670493232969 0.9999999999999908 0.351067753941825 9 P50402,P02545,P42167 3 +Formation of atp by chemiosmotic coupling 0.725915407933181 2.2049374196520213 0.0274584862328892 1.0 0.3708228577664948 9 P06576,O75964,P24539 3 +Synthesis of pa 0.677226311792641 2.195084841811769 0.0281575123472039 1.0 0.3733859149473224 12 Q8N2A8,Q9HCL2,Q9NPH0,Q8NAN2,Q8NF37 5 +Synthesis of very long chain fatty acyl coas 0.750728458866058 2.172541686880218 0.0298148288581254 1.0 0.3736174678492502 8 Q9NZ01,Q9P035,Q9UKU0 3 +Regulation of insulin like growth factor igf transport and uptake by insulin like growth factor binding proteins igfbps 0.6020927343466024 2.171994610500565 0.0298560694357403 1.0 0.3736174678492502 18 O43852,Q07065,Q02818,P05067,O43493,O76024 6 +Peptide ligand binding receptors 0.7793968361301957 2.1619766066694224 0.03061997939239 1.0 0.3736174678492502 7 P42892,P07602,Q9NZJ7 3 +Class a 1 rhodopsin like receptors 0.7793968361301957 2.1619766066694224 0.03061997939239 1.0 0.3736174678492502 7 P42892,P07602,Q9NZJ7 3 +Initiation of nuclear envelope ne reformation 0.617436642831936 2.123926479041827 0.0336762918341604 1.0 0.3944180545228778 15 P02545,P20700,P50402,Q14739,P42167 5 +Intra golgi traffic 0.6094196339905447 2.1197339764124457 0.0340284859804371 1.0 0.3944180545228778 16 Q16706,O15498,O00461,Q8TBA6,O95249,Q99747 6 +Processing of smdt1 0.6764564310744827 2.1042442986323553 0.0353571421537715 1.0 0.3944180545228778 11 Q8NE86,Q9UJZ1,Q99623,Q9Y4W6,Q8WWC4,Q9BPX6,Q10713,Q96TA2,P35232 9 +Cytoprotection by hmox1 0.4310509286086924 2.0924563074694107 0.0363977163457911 1.0 0.3944180545228778 62 P09601,O14548,Q8N8Q8,P28072,P61289,P30519,P13073,P00403,O75880,O43819,P49721,O00231 12 +N glycan trimming in the er and calnexin calreticulin cycle 0.6031349755871095 2.0802459194730187 0.0375029823746073 1.0 0.3982186907105255 16 O60858,P27824,Q04323,Q9UBV2,Q9GZP9 5 +Rhoa gtpase cycle 0.4893477481267835 2.0631091414309246 0.0391022598472303 1.0 0.4073955992128911 47 O14578,O15498,Q96HY6,P28288,Q96CS3,Q8NBN3,P30519,P51572,Q15904,Q8TAA9,P27105,Q86UP2,O75955,O15173,O75962,Q14739,Q5T8D3,P42167 18 +Heparan sulfate heparin hs gag metabolism 0.8246268656716397 2.05314572917958 0.0400584460329971 1.0 0.4097154296463162 5 P54802,P16278,Q7LGA3,Q96L58 4 +Chondroitin sulfate dermatan sulfate metabolism 0.8173296047674556 2.02160015106976 0.0432176764493217 1.0 0.4233506193028629 5 Q8N6G5,Q8NCH0,P06865 3 +Selective autophagy 0.5228625480388506 2.0104695205363208 0.0443815189736502 1.0 0.4257565027058451 32 Q8IWA4,Q8N4H5,Q15388,Q9NS69,P21796,O96008,P08670 7 +Complex i biogenesis 0.5252033532558306 1.9873567316592349 0.0468828789519955 1.0 0.4259744564252718 29 Q9P0J0,O95168,O95299,O96000,P51970,Q86Y39,Q9Y6M9,P03886,O43676,O95139 10 +Transport of vitamins nucleosides and related molecules 0.7133727457370787 1.9872975245077027 0.046889435842147 1.0 0.4259744564252718 8 P12236,O00400,P05141,Q8TB61,P12235 5 +Ras processing 0.8020005809442222 1.954994916714628 0.0505836702611719 1.0 0.4453283881853808 5 O60725 1 +Cargo concentration in the er 0.6031828599397369 1.9412536566991103 0.0522275177220312 1.0 0.4512327773375497 14 Q5JRA6,P53634,Q15363,P49755,Q96PC5,O75396 6 +P75 ntr receptor mediated signalling 0.6287787006773962 1.9208572035276117 0.0547497124195783 1.0 0.4701040121952686 12 Q9NQC3,Q92542 2 +Transport of inorganic cations anions and amino acids oligopeptides 0.6979754120448304 1.9098270107456263 0.0561554902877934 1.0 0.4762944328678089 8 P30825,Q70HW3,P04920,Q9UBX3 4 +Keratan sulfate keratin metabolism 0.7513570314428493 1.893961982261514 0.05823005629185 1.0 0.4879398090479726 6 P06865,P16278,P34059,O43505 4 +Calnexin calreticulin cycle 0.660967331033293 1.8659255232442895 0.0620517861228462 1.0 0.5065614476086362 9 Q9UBV2,O60858,Q9GZP9 3 +Rhog gtpase cycle 0.5007019474081114 1.865309683209572 0.0621380086441636 1.0 0.5065614476086362 34 O15498,P84095,P50402,Q86XL3,O15173,O75962,P42167,Q14739,O95202 9 +Er quality control compartment erqc 0.8834466780644119 1.851143239232939 0.06414894896969 1.0 0.5069953864593116 4 Q9UBV2,O60858 2 +Pre notch processing in golgi 0.8773244953891745 1.8264070543343345 0.0677889700658869 1.0 0.5177712064625385 4 Q9UBV2,Q15363 2 +Post translational modification synthesis of gpi anchored proteins 0.6766680741028989 1.8015684265083929 0.071613332542044 1.0 0.5298624764148047 8 Q96S52,Q5H8A4,Q92643 3 +Rac2 gtpase cycle 0.4890747033224204 1.78663487935815 0.0739965204834347 1.0 0.5398486731639432 35 P50402,Q9Y512,Q13505,Q86XL3,O15173,O75962,Q14739,P42167 8 +Miro gtpase cycle 0.7623297002688064 1.7805504976932365 0.0749859128232559 1.0 0.5403773169049629 5 Q8IXI1,Q8IWA4 2 +Antigen presentation folding assembly and peptide loading of class i mhc 0.5495976872051365 1.7796268195261995 0.0751370540407692 1.0 0.5403773169049629 17 Q03519,Q6P179,Q9NZ08,P51572,Q03518,P10321,P27824 7 +Death receptor signalling 0.5320266142330451 1.7541555050338782 0.0794038650539388 1.0 0.5606638390356797 19 Q9NQC3,Q8TCT8,Q92542 3 +Cellular response to chemical stress 0.3943720582372 1.7353917166751462 0.0826714462641866 1.0 0.5664826687363727 73 P20674,P09601,O14548,Q9UL46,Q8N8Q8,P61289,P30519,P13073,P28072,P00403,O75880,O43819,Q8TED1,Q13616,P49721,Q04656,O00231 17 +Integrin cell surface interactions 0.8512845735861279 1.7206656479930105 0.0853115133606947 1.0 0.578689333052765 4 Q08722 1 +Keratan sulfate degradation 0.748378831102545 1.7185247915448678 0.0857009364549745 1.0 0.578689333052765 5 P06865,P16278,P34059 3 +Interleukin 4 and interleukin 13 signaling 0.5889348346939228 1.6889820347701576 0.0912228728111916 1.0 0.5880046195866433 12 P08670,Q07820,P09601 3 +Tp53 regulates metabolic genes 0.4747924845824806 1.684495131957189 0.0920860194695825 1.0 0.5880046195866433 36 Q15382,P20674,O14548,Q8N8Q8,P04637,P13073,P00403,O75880,O43819,P31751 10 +G alpha s signalling events 0.678792279417878 1.6767034206011873 0.0936004914049732 1.0 0.5880046195866433 7 P63096,P63218,P04899 3 +Transport to the golgi and subsequent modification 0.3914922104714825 1.6626608645055925 0.0963803402341874 1.0 0.5880046195866433 76 Q9Y6Y8,O15498,Q15363,Q96PC5,Q13509,Q9Y296,Q9Y3B3,P53634,P24390,Q9HCU5,Q14789,Q13561,O95249,O75935,Q5JRA6,P62820,Q16706,Q9BVK6,P49755,O75396 20 +Diseases associated with n glycosylation of proteins 0.7324349099592614 1.647232253919321 0.0995103165972726 1.0 0.6017020369231328 5 Q9BT22,Q96AA3 2 +Immunoregulatory interactions between a lymphoid and a non lymphoid cell 0.6980838143461245 1.6440563343205818 0.1001645664397481 1.0 0.6017020369231328 6 P04439,Q5KU26,P10321 3 +Er to golgi anterograde transport 0.3871457170113986 1.6377484520582488 0.1014741787218558 1.0 0.6057964918545127 74 Q9Y6Y8,O15498,Q15363,Q96PC5,Q13509,Q9Y296,Q9Y3B3,P53634,P24390,Q9HCU5,Q14789,Q13561,O95249,O75935,Q5JRA6,P62820,Q9BVK6,P49755,O75396 19 +Rhod gtpase cycle 0.4761378875696725 1.5858983980382253 0.1127623592889603 1.0 0.6126214576153465 27 P20700,Q8NHP6,P50402,Q8TAA9,Q9UEY8,O15173,Q14739,P42167 8 +G alpha z signalling events 0.6839972961684582 1.5770418718895156 0.1147858908135082 1.0 0.6126214576153465 6 P63096,P63218,P04899,Q9UBI6 4 +Egr2 and sox10 mediated initiation of schwann cell myelination 0.6311923549579113 1.566628377618674 0.1172015807969655 1.0 0.6126214576153465 8 Q16850,P04035 2 +Striated muscle contraction 0.8135091367916294 1.5658985571324884 0.1173723677087557 1.0 0.6126214576153465 4 P08670 1 +Heme degradation 0.9466384310764906 1.564276621547465 0.1177526199197367 1.0 0.6126214576153465 3 P09601 1 +Biological oxidations 0.4500297873282795 1.5621399155614362 0.1182550314372163 1.0 0.6126214576153465 41 P16435,Q9NX62,Q8TB61,Q9UJ14,Q16850,O43169,Q9NUJ1,P21964,Q99735 9 +Iron uptake and transport 0.5101809180444413 1.5568463461799618 0.1195069705835893 1.0 0.6126214576153465 18 P30519,P09601,Q93050 3 +Unfolded protein response upr 0.4557047774508003 1.5558801697111897 0.1197365896963589 1.0 0.6126214576153465 38 O95070,P02545,Q9NWM8,Q9NQT5,P43307,Q9Y5M8,O76024 7 +Autophagy 0.4221092216545857 1.5532620392946184 0.1203605452595943 1.0 0.6126214576153465 51 Q15382,Q8IWA4,Q8N4H5,Q15388,Q9NS69,P21796,Q7Z3C6,O96008,P08670,P13473 10 +Diseases associated with glycosaminoglycan metabolism 0.8096012471293887 1.54980732893861 0.1211877674328361 1.0 0.6126214576153465 4 Q8NCH0,P06865 2 +Asparagine n linked glycosylation 0.4209962212474751 1.5373898110338255 0.1241978799766554 1.0 0.6126214576153465 115 Q9Y6Y8,O15498,Q15363,Q96PC5,Q13509,Q9BT22,Q96AA3,Q9Y296,P10619,Q9Y3B3,Q9UBV2,Q9GZP9,P16278,P53634,Q9BUN8,P24390,Q9HCU5,Q14789,Q13561,O95249,P04843,O75935,Q5JRA6,P62820,P27824,O60858,Q16706,Q9BVK6,Q86YN1,P49755,O75396,Q04323,P46977,Q2TAA5 34 +Peroxisomal lipid metabolism 0.5616712686924046 1.5271975937309272 0.1267118844913661 1.0 0.6184429169385626 12 Q9BY49,O43808,P51648,O15254,Q5T8D3 5 +Maturation of sars cov 2 spike protein 0.58361371294434 1.5112844809829111 0.1307159861669216 1.0 0.6335398493316653 10 P27824,Q16706,P46977 3 +Synthesis of pc 0.7007617958713546 1.504431459042193 0.1324703091625008 1.0 0.6351307929894153 5 P35790 1 +Gaba b receptor activation 0.7000287370247347 1.5011095060286712 0.1333272405125156 1.0 0.6351307929894153 5 P63096,P63218,P04899 3 +Gaba receptor activation 0.7000287370247347 1.5011095060286712 0.1333272405125156 1.0 0.6351307929894153 5 P63096,P63218,P04899 3 +Adp signalling through p2y purinoceptor 12 0.7000287370247347 1.5011095060286712 0.1333272405125156 1.0 0.6351307929894153 5 P63096,P63218,P04899 3 +Intra golgi and retrograde golgi to er traffic 0.3977945621611145 1.4986687243850805 0.133959594213666 1.0 0.6359651725297248 95 O15498,Q15363,Q13509,P52732,Q9P2W9,Q8N2H4,Q9Y3B3,P24390,Q9NSK0,Q8TBA6,Q13561,O95249,Q8N6T3,O43493,Q12981,Q99747,P40616,O75935,P62820,O60499,Q8TD16,P33176,Q16706,Q9BVK6,Q13409,P49755,O75396,O00461,Q9H0U4,Q9Y496,Q10472,Q6NUQ1,Q14746 33 +Basigin interactions 0.6664098408467523 1.4928843262677842 0.1354674686163934 1.0 0.6366055704236598 6 P53985,P08195,P54709,P35613 4 +Heme biosynthesis 0.6640243845367276 1.481430746697851 0.1384918265279187 1.0 0.642140435667783 6 Q7KZN9 1 +Synthesis of pe 0.93041317179248 1.4780943779786822 0.13938251868352 1.0 0.6436784637828024 2 P35790 1 +Diseases of glycosylation 0.4914846182738034 1.4700065710551409 0.141559974312867 1.0 0.6439726422557575 19 P16278,Q9BT22,Q8NCH0,Q96AA3,Q96L58,P06865,P10619,O43505,Q2TAA5 9 +Nucleotide binding domain leucine rich repeat containing receptor nlr signaling pathways 0.5830634545906315 1.4430206704324868 0.1490146484752648 1.0 0.6559473924971307 9 P09601 1 +Cell death signalling via nrage nrif and nade 0.6291325515294321 1.4287887186251378 0.1530649690276768 1.0 0.6649181163295281 7 Q92542 1 +Synthesis of pg 0.9111249223119906 1.427476333048454 0.1534426422298911 1.0 0.6649181163295281 3 Q8IV08,Q8N2A8 2 +Diseases of carbohydrate metabolism 0.5789856220770406 1.4204543076077711 0.155475461927228 1.0 0.6688772622797453 9 P10253,P16278,P34059,P54802 4 +Signal amplification 0.5777312650174853 1.4135054318595308 0.1575071653853259 1.0 0.6720627823649951 9 P50148,P63096,P63218,P04899 4 +Hs gag degradation 0.9102205653929758 1.395403659159156 0.1628941485151203 1.0 0.6929228152432181 2 P54802 1 +Mucopolysaccharidoses 0.7681069319241329 1.3782460696131522 0.1681273277863142 1.0 0.7016697598397182 4 P16278,P34059,P54802 3 +Organelle biogenesis and maintenance 0.3895767164722723 1.3777261104003344 0.1682878666728546 1.0 0.7016697598397182 97 O75935,P41208,P06576,Q5XKP0,O94927,P56385,P24539,Q9Y512,Q13505,Q16891,Q9BUR5,Q6UXV4,O75964,Q13561,Q10713,O75431,Q9H6D7,Q9NX63 18 +Golgi to er retrograde transport 0.3571595667603071 1.3602552189208117 0.1737491739894239 1.0 0.7098355366965897 68 Q15363,Q13509,Q9P2W9,Q9Y3B3,P24390,Q9NSK0,Q13561,Q12981,Q99747,O75935,P62820,Q8TD16,Q9BVK6,P49755,O75396,Q9H0U4,Q9Y496,Q10472,Q6NUQ1 19 +Phase i functionalization of compounds 0.5190697510487476 1.3395177350919787 0.1804021847925843 1.0 0.7223441592213085 13 Q16850,O43169 2 +Vitamin d calciferol metabolism 0.8871911366958747 1.3351829306211866 0.1818164821106558 1.0 0.7225906474740635 3 P04062 1 +Attachment of gpi anchor to upar 0.6577271435516453 1.3083727369935283 0.1907469150441156 1.0 0.7495168328428387 5 Q96S52,Q92643 2 +Retrograde transport at the trans golgi network 0.4421028277683926 1.2990306313253792 0.1939334172371478 1.0 0.7552443642220371 24 Q8N2H4,O60499 2 +Alpha oxidation of phytanate 0.748707913647474 1.2977410421585078 0.1943763352922281 1.0 0.7552443642220371 4 P51648,O43808 2 +Transport and synthesis of paps 0.8847468157812937 1.291337738079816 0.196586590096913 1.0 0.7559938013854083 2 Q8TB61 1 +Synthesis secretion and inactivation of glucagon like peptide 1 glp 1 0.7460271337374018 1.2866091832322788 0.1982305412750675 1.0 0.7559938013854083 4 P67812 1 +Incretin synthesis secretion and inactivation 0.7460271337374018 1.2866091832322788 0.1982305412750675 1.0 0.7559938013854083 4 P67812 1 +Miscellaneous transport and binding events 0.652674129353229 1.2852399319581091 0.1987084534918484 1.0 0.7559938013854083 5 Q9H0U3,Q9UEY8,Q8TDW0,P35611 4 +Endosomal vacuolar pathway 0.744971146460047 1.2822240077203182 0.1997640767277846 1.0 0.7559938013854083 4 P10321,Q9UIQ6 2 +Aquaporin mediated transport 0.6204878281223342 1.271038512858376 0.2037149478048108 1.0 0.7591713379776597 6 P10644,Q99797 2 +Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane 0.7372960836192328 1.2503502741375607 0.2111716208424869 1.0 0.7646170721026398 4 P12235,P12236 2 +Response to elevated platelet cytosolic ca2 0.4265606871272784 1.2484911886646883 0.2118512332255011 1.0 0.7646170721026398 34 Q96JJ7,O43852,P07602,Q8NBX0,Q9NZJ7,Q6UXV4,P05067,P13473,O94919 9 +Phase ii conjugation of compounds 0.4336248039890011 1.246612585558515 0.212539584736537 1.0 0.7646170721026398 27 Q9NX62,Q8TB61,Q9UJ14,Q9NUJ1,P21964,Q99735 6 +Acyl chain remodelling of pg 0.8720099409754547 1.2394890805407637 0.2151644301267317 1.0 0.7646170721026398 2 Q8NF37 1 +O linked glycosylation of mucins 0.6424895597356002 1.23856796533033 0.2155055377189247 1.0 0.7646170721026398 5 Q8N4A0,Q10472,O43505 3 +O linked glycosylation 0.6424895597356002 1.23856796533033 0.2155055377189247 1.0 0.7646170721026398 5 Q8N4A0,Q10472,O43505 3 +Bile acid and bile salt metabolism 0.5913000029926477 1.2371600098125854 0.2160276846415079 1.0 0.7646170721026398 7 Q9BZF3,P22307,Q9BXW6,P51659 4 +Synthesis of bile acids and bile salts 0.5913000029926477 1.2371600098125854 0.2160276846415079 1.0 0.7646170721026398 7 Q9BZF3,P22307,Q9BXW6,P51659 4 +Cytosolic sulfonation of small molecules 0.637063030449374 1.2136804086006006 0.2248697884528119 1.0 0.7819846893446535 5 Q9NX62,Q8TB61 2 +Peptide hormone metabolism 0.486879859331753 1.2075220827425586 0.2272311459381719 1.0 0.7850819174580401 14 P67812,Q96HE7,Q9UPT5,O75787,Q15005,P33176 6 +Signaling by braf and raf1 fusions 0.448727218955535 1.203699890388602 0.2287055946578844 1.0 0.7874492132898941 20 P02545,O43252,Q53H12,Q9NRY5 4 +Tp53 regulates transcription of cell death genes 0.7232578999037711 1.192063436233611 0.2332363724894834 1.0 0.79517596601194 4 Q92696 1 +Wax and plasmalogen biosynthesis 0.7221013366490456 1.1872632807928745 0.2351237869716418 1.0 0.7996508256174908 4 O00116,Q6IAN0,O15228 3 +Abc transporter disorders 0.4040259633079336 1.1828608293363638 0.2368643079333865 1.0 0.7996964769634398 43 Q9BUN8,Q9UL46,P28072,P61289,Q9NP58,P49721,Q9UBV2,Q9GZP9,O00231 9 +Biosynthesis of the n glycan precursor dolichol lipid linked oligosaccharide llo and transfer to a nascent protein 0.4567982764191332 1.1822655745764123 0.2371003406138128 1.0 0.7996964769634398 18 Q86YN1,Q9BT22,Q96AA3,P10619 4 +Translation of sars cov 1 structural proteins 0.6018655420044027 1.1804735793817982 0.2378119125899545 1.0 0.7996964769634398 6 Q10472 1 +Metabolism of steroid hormones 0.624705836570803 1.1569771938169713 0.2472816781713447 1.0 0.8186266483049941 5 Q8NBQ5,P30536,Q53GQ0 3 +Tp53 regulates transcription of several additional cell death genes whose specific roles in p53 dependent apoptosis remain uncertain 0.839417653463326 1.1514678186747758 0.2495398272432254 1.0 0.8190604240732103 3 Q92696 1 +Sulfur amino acid metabolism 0.5307507614047078 1.151167633184226 0.2496632780783905 1.0 0.8190604240732103 9 Q9UBX3 1 +Sialic acid metabolism 0.6195216971011357 1.133184612105828 0.2571367348261275 1.0 0.8288299427474505 5 P10619 1 +Activation of ampk downstream of nmdars 0.5483971366324355 1.1280618615806046 0.2592937944446603 1.0 0.8288299427474505 8 Q13131,P54619,Q13509,P54646,P04350,Q9BVA1,Q13885 7 +Copi mediated anterograde transport 0.372971537354456 1.1141090031215108 0.2652324267312713 1.0 0.8288299427474505 53 O75935,Q99747,O15498,Q9BVK6,Q15363,P62820,P24390,P49755,Q13509,Q9H0U4,Q14789,Q13561,O95249,Q9Y3B3 14 +Adrenaline noradrenaline inhibits insulin secretion 0.7031395710289013 1.1086498755754413 0.2675812531265773 1.0 0.8288299427474505 4 P63096,P63218,P04899 3 +Platelet calcium homeostasis 0.7022798088131808 1.1050904578247325 0.2691203948853329 1.0 0.8288299427474505 4 P20020,P16615 2 +Reduction of cytosolic ca levels 0.702279808813181 1.1050904578247325 0.2691203948853329 1.0 0.8288299427474505 4 P20020,P16615 2 +Pre notch expression and processing 0.5121767456519162 1.101990711963649 0.270465709568856 1.0 0.8288299427474505 10 Q9UBV2,Q15363,P16615 3 +Purinergic signaling in leishmaniasis infection 0.700511509045903 1.097771448442293 0.2723043018228503 1.0 0.8288299427474505 4 P09601 1 +The nlrp3 inflammasome 0.7005115090459031 1.097771448442293 0.2723043018228503 1.0 0.8288299427474505 4 P09601 1 +Inflammasomes 0.700511509045903 1.097771448442293 0.2723043018228503 1.0 0.8288299427474505 4 P09601 1 +Adp signalling through p2y purinoceptor 1 0.6107826102265229 1.0930843927723843 0.2743567478424149 1.0 0.8332537909362427 5 P50148,P63218 2 +Cell surface interactions at the vascular wall 0.4481328062811928 1.0856696453494736 0.2776251748845961 1.0 0.8363353524953263 17 P14174,P53985,P78310,Q92896,Q08722,P35613,P54709 7 +Apoptotic cleavage of cellular proteins 0.4313509009788107 1.074777132333714 0.2824745209373587 1.0 0.840177635833447 20 P08670,P02545,P51572,P49354 4 +Rab geranylgeranylation 0.4311633757250643 1.073381518546463 0.2830999732257866 1.0 0.840177635833447 20 P61026,Q969Q5,P62820,P61019,Q9BZG1,Q92696 6 +Aflatoxin activation and detoxification 0.6942556453481621 1.071899109594112 0.2837653501966364 1.0 0.840177635833447 4 Q9UJ14 1 +Chaperone mediated autophagy 0.5588462333549291 1.071730606536112 0.2838410495032351 1.0 0.840177635833447 7 P13473 1 +Copii mediated vesicle transport 0.4107697581079987 1.0716336626020853 0.2838846073628469 1.0 0.840177635833447 29 Q9Y6Y8,O15498,P53634,Q15363,P62820,P49755,O75396,Q9Y296,Q9HCU5,Q99747 10 +G alpha i signalling events 0.4106623541191284 1.0518151165597824 0.2928843821935014 1.0 0.8559093117374225 25 P50148,P10644,P52292,P07602,P04899,Q9NZJ7,P63096,P05067,P63218 9 +Insulin receptor recycling 0.5028635389901677 1.0480930643752926 0.2945957314342877 1.0 0.8559093117374225 10 Q93050,P61421,P36543,Q15904,Q9Y487 5 +Hs gag biosynthesis 0.8238583410997105 1.0454456376376629 0.2958170532943363 1.0 0.8559093117374225 2 Q7LGA3 1 +Pyruvate metabolism 0.4390883053960437 1.022283249796086 0.3066468586919835 1.0 0.8722817595921248 17 P48163,P21796,P09622,P35613 4 +Rac3 gtpase cycle 0.40035276106291 1.0138607279481775 0.3106492129727591 1.0 0.8745256853218308 33 O15498,P50402,Q8TAA9,O15173,O75962,P42167,Q14739,Q01968 8 +Metabolism of lipids 0.4377212236567168 1.0016935049857758 0.3164916445679628 1.0 0.8782822160760144 191 P38435,O43681,Q15392,P35790,P30536,Q96N66,Q8NAN2,Q96G23,O15269,Q15800,Q9UKU0,P10619,Q10713,P40939,Q9NZ01,P06865,Q16836,P53007,Q92604,O95674,P16278,P50897,P07602,P17900,Q8N2A8,Q9P035,P06280,P09960,Q13510,Q9NUQ2,P51648,Q9H7Z7,P50416,Q16850,O95470,Q9BVG9,P48651,P48163,Q15165,Q16739,Q14534,Q53GQ0,P04062,Q16880,Q15125,P23786,Q14739,Q9UG56,P37268,Q9HCL2,Q9NZJ7,Q9NPH0,P04035,Q8IV08,Q53H12,O00116,O15254,Q06136,Q8NF37 59 +Rnd2 gtpase cycle 0.426237906224909 0.9988502560114167 0.317867236498522 1.0 0.8782822160760144 19 Q07065 1 +Disorders of transmembrane transporters 0.3361373766644505 0.9973395569705418 0.3185997191740632 1.0 0.8782822160760144 76 Q8NFH5,O00400,Q9BUN8,Q9UL46,P28072,P61289,Q9NP58,P35613,Q8NFH4,Q9BTX1,P49721,Q9UBV2,Q9GZP9,O00231 14 +Cytochrome p450 arranged by substrate type 0.7975202719684471 0.9920612599236458 0.3211676429432684 1.0 0.8782822160760144 3 Q16850 1 +Hyaluronan uptake and degradation 0.6747795436782666 0.9916170633840482 0.3213843623168162 1.0 0.8782822160760144 4 P06865 1 +Hyaluronan metabolism 0.6747795436782664 0.9916170633840482 0.3213843623168162 1.0 0.8782822160760144 4 P06865 1 +Synaptic adhesion like molecules 0.5420461887575688 0.986054599694102 0.3241063206254946 1.0 0.8805310390430917 7 O95197,O75955,Q12959 3 +Defective cftr causes cystic fibrosis 0.3831582344804942 0.9708997045091462 0.3315982253347262 1.0 0.8921724012390798 42 Q9BUN8,Q9UL46,P28072,P61289,P49721,Q9UBV2,Q9GZP9,O00231 8 +Transferrin endocytosis and recycling 0.4791697340552059 0.9656621011821802 0.3342132895034855 1.0 0.8937220201889826 11 Q93050,P61421,P36543,Q15904,Q9Y487 5 +Adora2b mediated anti inflammatory cytokines production 0.4977029010536554 0.9652584671196972 0.3344153688749594 1.0 0.8937220201889826 9 P10644,P63218,P04899 3 +Abc transporters in lipid homeostasis 0.7902423865755053 0.9646506705233798 0.3347198107757103 1.0 0.8937220201889826 3 P40855,P56589 2 +Beta oxidation of pristanoyl coa 0.6650958354107798 0.9518949729010596 0.3411502493090637 1.0 0.895724109764904 4 O15254 1 +Abc family proteins mediated transport 0.3542449769436021 0.945306805862442 0.3445022648184979 1.0 0.8976470503309449 54 Q9NRK6,O75477,Q9BUN8,Q9UL46,P28288,P61289,P28072,Q9NUT2,Q9NP58,O94905,P28070,P56589,P40855,P49721,Q9UBV2,Q9GZP9,O00231 17 +Transport of bile salts and organic acids metal ions and amine compounds 0.7820038591892049 0.933751282058228 0.3504322051846535 1.0 0.9016554275033466 3 Q15043 1 +Dna damage recognition in gg ner 0.4214194231434709 0.9295108426459572 0.3526244087432211 1.0 0.9016554275033466 18 P41208,P54725,Q9BT78,Q92905,Q7L5N1 5 +Synthesis secretion and deacylation of ghrelin 0.7777385926215177 0.9178125891448032 0.35871699024944 1.0 0.9032209657921634 3 P67812 1 +Synthesis secretion and inactivation of glucose dependent insulinotropic polypeptide gip 0.7777385926215177 0.9178125891448032 0.35871699024944 1.0 0.9032209657921634 3 P67812 1 +Copi dependent golgi to er retrograde traffic 0.3673620003979943 0.9102706987461848 0.3626797673225848 1.0 0.9077778262702324 47 Q99747,Q9BVK6,Q6NUQ1,Q15363,P62820,P24390,P49755,Q13509,O75396,P52732,Q9NSK0,Q9P2W9,Q9H0U4,Q9Y496,Q12981,Q9Y3B3 16 +Ros and rns production in phagocytes 0.4878646911119268 0.9099477093464198 0.3628500872798341 1.0 0.9077778262702324 9 Q93050 1 +Notch3 activation and transmission of signal to the nucleus 0.7878223050636716 0.9035049929329392 0.3662579395373346 1.0 0.9097585605293438 2 Q92542 1 +The phototransduction cascade 0.5674251969129507 0.8949287956381976 0.3708251524767585 1.0 0.9150965820598423 5 P49354,P53582 2 +Binding and uptake of ligands by scavenger receptors 0.5045709800849809 0.8936566215023632 0.3715056413991462 1.0 0.9150965820598423 8 Q8WTV0 1 +Downregulation of erbb2 signaling 0.537961490045009 0.8698738880070702 0.3843693267876134 1.0 0.9303329683434534 6 Q16543,P31751 2 +Syndecan interactions 0.6448432698674111 0.8693911006150186 0.3846332490718886 1.0 0.9303329683434534 4 P05556,Q9Y296 2 +Proton coupled monocarboxylate transport 0.7788132960546643 0.8686484781146506 0.3850394300362425 1.0 0.9303329683434534 2 P35613 1 +Hedgehog ligand biogenesis 0.3750678140246453 0.8668419457607953 0.3860286158530117 1.0 0.9306166458432223 40 P28072,P49721,Q9UBV2,Q9GZP9,O00231 5 +Activation of nmda receptors and postsynaptic events 0.3871470513409708 0.8590548324569228 0.390310265076651 1.0 0.93602321893881 23 P10644,P52292,P07196,Q14168,P51812,Q12959 6 +Gamma carboxylation hypusine formation and arylsulfatase activation 0.4780162215808396 0.8546873800939225 0.3927242388194192 1.0 0.93602321893881 9 P38435,O60725 2 +Adenylate cyclase inhibitory pathway 0.7601820020576755 0.8526812331730992 0.3938361008130999 1.0 0.93602321893881 3 P04899 1 +Metabolism of steroids 0.3631544750947517 0.8496749714248106 0.3955058172696475 1.0 0.93602321893881 46 P38435,Q15392,P37268,Q9HCL2,P30536,Q53GQ0,Q14534,P04062,P04035,Q15800,Q16850,Q15125,Q14739 13 +Translation of sars cov 2 structural proteins 0.4184713043296327 0.8493737293718223 0.3956733664529261 1.0 0.93602321893881 16 P27824,Q16706,P46977,Q10472 4 +Copi independent golgi to er retrograde traffic 0.3849688110827064 0.8461529670133741 0.3974674157952109 1.0 0.9370189618319243 26 O75935,Q10472,Q13561 3 +Ub specific processing proteases 0.3194108268146374 0.8437245092530655 0.3988233683919988 1.0 0.9370189618319243 72 Q9UL46,P28072,P61289,P04637,P45880,Q9Y277,Q9UPU5,P21796,Q969V5,P49721,O00231 11 +Diseases associated with o glycosylation of proteins 0.7679403541472507 0.8269862597314932 0.4082448494543551 1.0 0.9370189618319243 2 O43505 1 +Plasma lipoprotein remodeling 0.7673190431811049 0.824619906543421 0.4095874161655761 1.0 0.9370189618319243 2 Q9BU23 1 +Aurka activation by tpx2 0.376280557184985 0.8143496589635204 0.4154446689176962 1.0 0.9370189618319243 34 O75935,P41208,O94927,O75330,Q13561,Q9H6D7 6 +Rho gtpases activate ktn1 0.5078434471939753 0.8125177906535735 0.4164945824054644 1.0 0.9370189618319243 7 Q9NSK0,P84095,Q86UP2 3 +Transport of connexons to the plasma membrane 0.5478855721392968 0.8065945187346091 0.4199001327162959 1.0 0.9370189618319243 5 Q9BVA1,Q13885,Q13509,P04350 4 +Gap junction assembly 0.5478855721392968 0.8065945187346091 0.4199001327162959 1.0 0.9370189618319243 5 Q9BVA1,Q13885,Q13509,P04350 4 +Platelet homeostasis 0.4431111999188381 0.8043472999637424 0.4211964277614592 1.0 0.9370189618319243 12 P63218,P20020,P16615 3 +Beta oxidation of lauroyl coa to decanoyl coa coa 0.6239534261973905 0.7853558010519992 0.4322449874377698 1.0 0.9462628181498212 4 P40939 1 +Beta oxidation of hexanoyl coa to butanoyl coa 0.6239534261973905 0.7853558010519992 0.4322449874377698 1.0 0.9462628181498212 4 P40939 1 +Metabolism of cofactors 0.5195210345805238 0.7812484535043515 0.4346563807518127 1.0 0.9462628181498212 6 P00374,O75208 2 +Ion homeostasis 0.4469584774011275 0.7741572568626484 0.4388378014092593 1.0 0.9462628181498212 11 P05023,P20020,P23634,P16615 4 +Wnt ligand biogenesis and trafficking 0.5404205601964169 0.7731091504562894 0.4394577861429076 1.0 0.9462628181498212 5 Q5T9L3 1 +Regulation of tp53 activity through association with co factors 0.7377814230617963 0.7708915189729559 0.4407712345272689 1.0 0.9476240915416246 3 P04637 1 +Ptk6 regulates proteins involved in rna processing 0.7333961480564211 0.755080543286728 0.4502006566651051 1.0 0.9575368706745584 3 P23246 1 +Signaling by notch 0.3242501003395248 0.7352217006465007 0.4622044849518767 1.0 0.9711227314590488 58 Q15363,P28072,P61289,P04637,Q92542,P49721,Q9UBV2,P16615,O00231 9 +Nr1h2 nr1h3 regulate gene expression linked to lipogenesis 0.7433985709847742 0.7348349883129786 0.4624399956649765 1.0 0.9711227314590488 2 O00767 1 +G alpha 12 13 signalling events 0.4917621054065191 0.7318115154348818 0.4642836194916029 1.0 0.9711227314590488 7 O75962 1 +Beta oxidation of butanoyl coa to acetyl coa 0.722456425900904 0.7159615174514113 0.4740151111900923 1.0 0.9711227314590488 3 P40939 1 +Thromboxane signalling through tp receptor 0.5965302803604522 0.6772922903159814 0.4982205215325082 1.0 0.9957252089823548 4 P50148,P63218 2 +Unwinding of dna 0.4446340683342561 0.6690855409636284 0.5034409128401272 1.0 0.9980437595135284 9 P33991,Q9BRT9,Q14566,Q9Y248 4 +Long term potentiation 0.4938373784969386 0.6596054122022048 0.5095070801949138 1.0 0.9980437595135284 6 Q14168,P07196 2 +Creb1 phosphorylation through nmda receptor mediated activation of ras signaling 0.4598397186870356 0.6575515678703664 0.5108263244714624 1.0 0.9980437595135284 8 Q14168,P51812,P07196 3 +Signaling by insulin receptor 0.3899827187760195 0.6543330209353864 0.5128972761504431 1.0 0.9980437595135284 16 Q93050,P61421,P36543,Q15904,Q9Y487,P31751 6 +G beta gamma signalling through pi3kgamma 0.7029210689869371 0.6473875087154953 0.5173811782599749 1.0 1.0 3 P63218,P31751 2 +G protein activation 0.7029210689869357 0.6473875087154912 0.5173811782599775 1.0 1.0 3 P50148,P63218 2 +Vasopressin regulates renal water homeostasis via aquaporins 0.5101222161595163 0.6392869607697871 0.522636269428276 1.0 1.0 5 P10644 1 +Glucagon signaling in metabolic regulation 0.5101222161595163 0.6392869607697871 0.522636269428276 1.0 1.0 5 P10644 1 +Recruitment of mitotic centrosome proteins and complexes 0.3559550870951738 0.632121809969938 0.5273072846845701 1.0 1.0 33 O75935,P41208,Q9H6D7,Q13561 4 +Prevention of phagosomal lysosomal fusion 0.5847062480571836 0.6317036916634056 0.5275805153052913 1.0 1.0 4 P20339,O14964,Q9H267 3 +Cdc42 gtpase cycle 0.3570687896665338 0.6316832146397859 0.527593898419739 1.0 1.0 31 O15498,Q8TAA9,P42166,Q68EM7,Q86YQ8,P27105,Q86UP2,O75962,Q14739,P42167 10 +Oncogenic mapk signaling 0.3568513864366203 0.616799744392216 0.5373668206092574 1.0 1.0 25 Q7Z569,P02545,Q9NRY5,O43252,Q53H12,O00203 6 +Anchoring of the basal body to the plasma membrane 0.3529697248235028 0.6123934214717152 0.5402774932452008 1.0 1.0 34 O75935,P41208,Q9H6D7,Q13561 4 +Regulation of plk1 activity at g2 m transition 0.3503028310907444 0.6109533452861202 0.5412304673463368 1.0 1.0 37 O75935,P41208,O94927,O95684,Q13561,Q13616,Q96CS2,Q9H6D7 8 +Assembly and cell surface presentation of nmda receptors 0.4184893557986229 0.6072479781469553 0.5436863563767376 1.0 1.0 11 Q14168,Q12959,P07196 3 +N glycan antennae elongation in the medial trans golgi 0.7061199130164548 0.6010779118300005 0.5477880944090938 1.0 1.0 2 Q16706 1 +Reactions specific to the complex n glycan synthesis pathway 0.7061199130164548 0.6010779118300005 0.5477880944090938 1.0 1.0 2 Q16706 1 +Signaling by gpcr 0.3401008598727416 0.5952914057275178 0.5516486996962855 1.0 1.0 44 P50148,P10644,P52292,P07602,P42892,Q9NZJ7,P05067,P51812,O75962,Q8NCG7,P31751,P63218,Q8N2K0 13 +Glycerophospholipid catabolism 0.7030133581857689 0.5903341346254057 0.5549666589168285 1.0 1.0 2 Q8IY17 1 +Potassium channels 0.7027027027026913 0.5892635231708985 0.5556845102594972 1.0 1.0 2 P63218 1 +Glucagon type ligand receptors 0.7027027027026913 0.5892635231708985 0.5556845102594972 1.0 1.0 2 P63218 1 +Prostacyclin signalling through prostacyclin receptor 0.7027027027026913 0.5892635231708985 0.5556845102594972 1.0 1.0 2 P63218 1 +Presynaptic function of kainate receptors 0.7027027027026913 0.5892635231708985 0.5556845102594972 1.0 1.0 2 P63218 1 +Inwardly rectifying k channels 0.7027027027026913 0.5892635231708985 0.5556845102594972 1.0 1.0 2 P63218 1 +Linoleic acid la metabolism 0.7002174588381441 0.580723634666943 0.5614267300394034 1.0 1.0 2 P33121 1 +Negative regulation of nmda receptor mediated neuronal transmission 0.4963780470184922 0.5800127265155485 0.5619060355772079 1.0 1.0 5 Q14168,P07196 2 +Unblocking of nmda receptors glutamate binding and activation 0.4963780470184922 0.5800127265155485 0.5619060355772079 1.0 1.0 5 Q14168,P07196 2 +Ras activation upon ca2 influx through nmda receptor 0.4963780470184922 0.5800127265155485 0.5619060355772079 1.0 1.0 5 Q14168,P07196 2 +Aspartate and asparagine metabolism 0.4957782733762805 0.5774508922529542 0.5636349033413188 1.0 1.0 5 Q9UJS0 1 +Nuclear envelope ne reassembly 0.3315690664345473 0.5754508880694349 0.5649863964585118 1.0 1.0 48 Q9BTX1,P02545,Q8NFH5,P20700,Q92973,P50402,Q9BW27,Q9Y3E7,Q13509,Q8N1F7,Q86XL3,P42166,Q8NFH4,Q7Z3B4,Q14739,P42167 16 +Josephin domain dubs 0.6812715821760487 0.5736278359108863 0.5662196710755201 1.0 1.0 3 P54725 1 +Pi5p regulates tp53 acetylation 0.6811684275947641 0.5732826786854301 0.5664533114839161 1.0 1.0 3 Q8TBX8,P04637 2 +Rhoj gtpase cycle 0.3546841291973974 0.5654723249989937 0.5717525429784236 1.0 1.0 22 Q6IAA8,O75323,Q8TAA9,P42166,P27105,O75962,P42167,Q86YQ8,Q01968 9 +Class b 2 secretin family receptors 0.6777665928632196 0.5619357353126369 0.5741598051476826 1.0 1.0 3 P63218 1 +Platelet activation signaling and aggregation 0.3047891117454056 0.5451374430044611 0.5856589922656852 1.0 1.0 59 Q96JJ7,P84095,O43852,P07602,O94919,Q9Y6I9,Q8NBX0,Q9NZJ7,Q6UXV4,P05067,Q8NCG7,P13473,P63218,Q8N2K0,Q08380,Q9NUQ9 16 +Tp53 regulates transcription of death receptors and ligands 0.6658650032600608 0.5228038558883141 0.6011107560416862 1.0 1.0 3 P04637 1 +Cd28 dependent pi3k akt signaling 0.6628561767228619 0.5130568534071231 0.6079115517720901 1.0 1.0 3 P31751 1 +Meiotic synapsis 0.3677831255184866 0.5049964452075528 0.6135613327372953 1.0 1.0 16 P02545,P20700,Q9UH99,P38398,Q8WXH0,Q8WVM7 6 +Vitamin c ascorbate metabolism 0.6713264989127019 0.4849591638869136 0.6277053129660999 1.0 1.0 2 P00387 1 +Synthesis of substrates in n glycan biosythesis 0.3743415230344053 0.4790851422642121 0.6318780591633573 1.0 1.0 14 Q86YN1,P10619 2 +Ikk complex recruitment mediated by rip1 0.5396331986322722 0.4654311263440769 0.6416227482164674 1.0 1.0 4 P61088,Q13546,O14920 3 +Ddx58 ifih1 mediated induction of interferon alpha beta 0.3615446825403012 0.4637378304197918 0.6428355898522549 1.0 1.0 16 P05067 1 +Tetrahydrobiopterin bh4 synthesis recycling salvage and regulation 0.6452620656764926 0.4573334847086097 0.6474313654452291 1.0 1.0 3 P00374 1 +Cardiac conduction 0.3826707201668622 0.4428797255254713 0.6578527328865413 1.0 1.0 12 P05023,P20020,P23634,P16615 4 +Synthesis of bile acids and bile salts via 7alpha hydroxycholesterol 0.6366580682425969 0.4309274839474339 0.6665210987548211 1.0 1.0 3 P51659 1 +Chk1 chk2 cds1 mediated inactivation of cyclin b cdk1 complex 0.4000622665006204 0.4301596700629662 0.6670794968316349 1.0 1.0 9 P62258,Q04917,P14635,Q9Y3B8,P61981,P06493,P31946,P63104 8 +Antigen processing cross presentation 0.3114874266138621 0.4284288022029613 0.6683389589137465 1.0 1.0 51 Q03519,O00231,Q9UIQ6,Q9UL46,P04439,P61289,P28072,O75396,Q03518,P10321,P49721,Q9UBG0 12 +Signaling by hedgehog 0.2985311840429505 0.4213571740042395 0.6734942865087827 1.0 1.0 57 P10644,P28072,P61289,P49721,Q9UBV2,Q9GZP9,O00231 7 +Defective intrinsic pathway for apoptosis 0.3522008393350626 0.4027160983592169 0.6871570897155079 1.0 1.0 16 P05067,P02545,P20700 3 +Tryptophan catabolism 0.6439888164026036 0.4010926967531654 0.6883518776244242 1.0 1.0 2 P08195 1 +Rhof gtpase cycle 0.3487617058360082 0.3973114893897163 0.6911377758888038 1.0 1.0 17 P42167,P20700,Q8TAA9 3 +Lysine catabolism 0.4210801922730838 0.393062498219036 0.6942733215567738 1.0 1.0 7 Q9BQT8 1 +Trans golgi network vesicle budding 0.3259080030931698 0.3913192543429939 0.6955612684213881 1.0 1.0 36 P55327,P05067,O43493,Q9Y5X3,O60749,O00203 6 +Regulated necrosis 0.3475192290855849 0.3891005353092446 0.6972017775041539 1.0 1.0 17 Q9UNE7,Q9Y3E7,P04637,O75955,P49327,Q16543,Q14254 7 +Golgi associated vesicle biogenesis 0.3258628753245238 0.3698279093217262 0.7115107186665375 1.0 1.0 29 P55327,O43493,Q9Y5X3,O60749,O00203 5 +Mitotic g2 g2 m phases 0.3001746517387762 0.369789270142738 0.7115395106274209 1.0 1.0 91 O75935,P41208,O94927,P28072,P61289,P04637,Q99640,Q96CS2,Q13561,O75330,P49721,Q9H6D7,O00231 13 +Activation of bad and translocation to mitochondria 0.399937752878932 0.3586124411377771 0.7198850383854829 1.0 1.0 8 P62258,Q04917,Q9Y3B8,P61981,P31751,P31946,P63104 7 +Regulation of commissural axon pathfinding by slit and robo 0.6115599751398477 0.3574214720730773 0.7207763045602911 1.0 1.0 3 O94813,Q9Y6N7 2 +Nef mediated downregulation of mhc class i complex cell surface expression 0.4412313432835736 0.3559666566772407 0.7218655359053596 1.0 1.0 5 P04439,Q9BXS5,Q10567,O43747 4 +Recruitment of numa to mitotic centrosomes 0.3200031038921967 0.3524801687318665 0.7244781884386282 1.0 1.0 38 O75935,P41208,Q68CZ6,O94927,O95684,Q13561,Q96CS2,Q9H6D7 8 +Ripk1 mediated regulated necrosis 0.3721975780136178 0.3476768842355704 0.7280828585952643 1.0 1.0 11 Q14254,O75955,Q16543,Q9UNE7 4 +Irak1 recruits ikk complex 0.6247281764523072 0.3465338220344072 0.7289415706173519 1.0 1.0 2 O14920 1 +Beta oxidation of octanoyl coa to hexanoyl coa 0.4349034588193406 0.3321029517697537 0.739811521319159 1.0 1.0 5 P40939 1 +Beta oxidation of decanoyl coa to octanoyl coa coa 0.4349034588193406 0.3321029517697537 0.739811521319159 1.0 1.0 5 P40939 1 +Downregulation of erbb4 signaling 0.6113699906803272 0.3111055611248981 0.7557203736264064 1.0 1.0 2 Q96J02 1 +Insulin processing 0.3764009962640076 0.3108630297509467 0.755904750909199 1.0 1.0 9 O60645,Q8IYI6,Q96HE7,Q9UPT5,Q8TAG9,Q86YB8,Q96KP1,P33176 8 +Mastl facilitates mitotic progression 0.4923842088902804 0.3086645899608891 0.7575766824658123 1.0 1.0 4 P14635,P30154,P06493 3 +Protein protein interactions at synapses 0.3371456608373634 0.3068120747119733 0.7589864169632896 1.0 1.0 16 Q14168,O95197,O75955 3 +G protein beta gamma signalling 0.426029722604096 0.2994309310306499 0.7646112645954366 1.0 1.0 5 P63218 1 +Glucagon like peptide 1 glp1 regulates insulin secretion 0.4115265997256707 0.2985318744253387 0.7652972522795234 1.0 1.0 6 P10644 1 +Regulation of hmox1 expression and activity 0.3063001009077388 0.2911107121232406 0.7709666474716477 1.0 1.0 45 P28072,P49721,P09601,O00231 4 +Activation of bh3 only proteins 0.3552508569647936 0.2894233154777811 0.7722574549358765 1.0 1.0 12 P62258,Q13625,Q04917,P04637,Q9Y3B8,P63167,P27348,P61981,P31751,P31946,P63104 11 +Thrombin signalling through proteinase activated receptors pars 0.408799389806165 0.2877404242385549 0.7735454439282288 1.0 1.0 6 P63218 1 +Mitochondrial fatty acid beta oxidation of saturated fatty acids 0.4076094038081074 0.2830628702596949 0.7771286432944966 1.0 1.0 6 P40939 1 +Diseases of immune system 0.5992544268406245 0.2807806343867422 0.7788786578736437 1.0 1.0 2 O14920 1 +Stabilization of p53 0.3107614033993608 0.2733201066338757 0.7846071606922767 1.0 1.0 38 P28072,P61289,P04637,P49721,O00231 5 +Synthesis of pips at the golgi membrane 0.3808289461260281 0.2710112514230322 0.7863823786087623 1.0 1.0 8 Q9BTU6,Q9NTJ5,Q10713 3 +Vitamin b5 pantothenate metabolism 0.4042414802572155 0.2699292643994126 0.7872146728122806 1.0 1.0 6 P49327,Q9Y289,P16260 3 +Signaling by notch4 0.3055351209145852 0.2641489696601966 0.791665131130745 1.0 1.0 43 P28072,P49721,Q92542,O00231 4 +Hsp90 chaperone cycle for steroid hormone receptors shr in the presence of ligand 0.3118796383732117 0.2596228114913297 0.7951547385263571 1.0 1.0 29 O75935 1 +Regulation of localization of foxo transcription factors 0.3996889580093257 0.2524292623061303 0.8007092842659416 1.0 1.0 6 Q9Y3B8,P61981,P31751,P31946,P63104 5 +Ticam1 rip1 mediated ikk complex recruitment 0.5674331883157357 0.2427713743105142 0.8081825122387982 1.0 1.0 3 P61088,O14920 2 +Caspase activation via extrinsic apoptotic signalling pathway 0.4696922598694536 0.2418060671436557 0.8089304375016644 1.0 1.0 4 Q13546,P49327,Q9UKG1 3 +G alpha q signalling events 0.3346818715046468 0.2416390843116831 0.8090598344435851 1.0 1.0 14 Q8N2K0,P05067,P51812,Q8NCG7,P63218,O75962 6 +Nuclear envelope breakdown 0.3053324699144525 0.2390964304693026 0.8110308095921799 1.0 1.0 40 P02545,P20700,P50402,Q8NFH4,Q9BTX1,P42167 6 +Rhoc gtpase cycle 0.3081322613652609 0.2318771412722363 0.8166334393208969 1.0 1.0 32 O14578,P28288,Q8TAA9,P27105,O75955,Q14739,Q5T8D3,P42167 8 +Pyruvate metabolism and citric acid tca cycle 0.3054323479706559 0.2237904220041389 0.8229203831035068 1.0 1.0 37 P48163,Q9H9P8,P21796,P09622,Q9P0J1,Q13423,P35613,P21912 8 +Transcriptional regulation by runx3 0.3015973580886431 0.221053029144411 0.8250511428294087 1.0 1.0 42 P28072,P61289,P04637,P49721,O00231 5 +Cdt1 association with the cdc6 orc origin complex 0.3031385560724855 0.2203491034519708 0.825599280756723 1.0 1.0 40 P28072,P49721,Q9Y619,O00231 4 +Signaling by flt3 fusion proteins 0.4020522388059616 0.2162952515581422 0.8287576101749228 1.0 1.0 5 Q01082,Q92614,P62993,Q14789 4 +Regulation of lipid metabolism by pparalpha 0.3130573144437574 0.2136390021357735 0.8308285821916734 1.0 1.0 20 P48163,P37268,P04035,P23786 4 +Toll like receptor tlr1 tlr2 cascade 0.3195785057495799 0.2108765022032042 0.8329836403470872 1.0 1.0 17 P05067,Q9BQ95,P51812 3 +G1 s dna damage checkpoints 0.300734634517214 0.1943070112419783 0.8459354960827918 1.0 1.0 39 P28072,P61289,P04637,P49721,O00231 5 +Formyl peptide receptors bind formyl peptides and many other ligands 0.5448341078817285 0.1922242525890334 0.847566549316114 1.0 1.0 3 P05067 1 +Neuronal system 0.2818705099251976 0.1836943007173867 0.8542532801973572 1.0 1.0 54 P10644,O95197,P52292,P07196,Q14168,Q13509,P51812,O75955,P63218,O75915,P21964,Q12959 12 +Hemostasis 0.3169481230404106 0.175406366192687 0.8607603386395148 1.0 1.0 127 Q13509,P04899,P20020,Q9UIJ7,P16615,P10644,P07602,O43852,O43572,P23634,Q6UXV4,Q9NSK0,P05067,P63218,Q9NUQ9,O94919,Q96JJ7,P84095,Q9Y6I9,P42785,Q8NCG7,Q8N2K0,P54709,Q08380,P50148,Q8IWA4,O95140,P04637,Q9NZJ7,Q8NBX0,Q92896,P13473,Q08722,P35613 34 +Muscle contraction 0.299712751449276 0.1723047615222595 0.8631979411858179 1.0 1.0 26 P23634,P20020,P05023,P67936,P16615,P08670 6 +Synthesis of ip2 ip and ins in the cytosol 0.5332711193953806 0.1686700588511334 0.8660561708822088 1.0 1.0 3 Q96PE3 1 +Sensory processing of sound 0.313884555382213 0.1664880735572538 0.8677728681134893 1.0 1.0 16 P56545,Q00013,P23634,Q13813,P15311,P47756,P35579,P20020,O14936,Q6IBS0,Q9Y2J2,P26038,Q01082,O00159,P35241 15 +Interleukin 1 signaling 0.2940965205291159 0.1636755927674606 0.8699865325493406 1.0 1.0 43 P28072,P61289,P05067,P49721,O00231 5 +Plasma lipoprotein clearance 0.3147863548160025 0.1634972471671818 0.8701269404314138 1.0 1.0 15 O15118,Q8WTV0 2 +Tyrosine catabolism 0.536191363777568 0.1527863885128234 0.8785667320952086 1.0 1.0 2 O43708 1 +Tysnd1 cleaves peroxisomal proteins 0.3815610571284458 0.1519979848772592 0.8791885250202451 1.0 1.0 5 O00116 1 +Regulation of pyruvate dehydrogenase pdh complex 0.3408880986859784 0.1475434397289554 0.8827030949415997 1.0 1.0 9 P09622 1 +Constitutive signaling by overexpressed erbb2 0.4299036369288257 0.1406730503627695 0.8881282360465874 1.0 1.0 4 Q96RT1,P07900,Q16543 3 +Trafficking and processing of endosomal tlr 0.5222118670394384 0.1313898407208653 0.8954669249235412 1.0 1.0 2 Q99538 1 +Diseases associated with glycosylation precursor biosynthesis 0.3463554930335419 0.1276719687432733 0.8984085742192902 1.0 1.0 8 P10619 1 +Activation of ppargc1a pgc 1alpha by phosphorylation 0.5049720323182184 0.1178303116479129 0.9062021116214936 1.0 1.0 3 P54646,P54619 2 +Phosphorylation of emi1 0.5009322560596736 0.1113676045709763 0.9113248480322718 1.0 1.0 3 P53350,P06493 2 +Activation of smo 0.507300403852111 0.1112990845827393 0.9113791812938852 1.0 1.0 2 Q9Y496 1 +Inactivation of cdc42 and rac1 0.4140503574759165 0.1066557425048049 0.9150620946201116 1.0 1.0 4 O94813,Q9Y6N7,P60953 3 +Suppression of phagosomal maturation 0.3487865588052249 0.1035729582890666 0.9175082483803996 1.0 1.0 7 Q9UI12,Q14974,P20339,O14964,Q9H267,P51149 6 +Regulation of insulin secretion 0.3175608189458842 0.0992441706585783 0.9209444048314728 1.0 1.0 12 P50148,P10644,P63218,P04899 4 +Rhot1 gtpase cycle 0.4970487729108406 0.0990708484811017 0.9210820177355026 1.0 1.0 2 P52306 1 +Signaling by notch1 pest domain mutants in cancer 0.3291709924341444 0.0990132486046052 0.9211277509307418 1.0 1.0 9 Q92542 1 +Pregnenolone biosynthesis 0.4921668132159833 0.0980254718542353 0.9219120671547494 1.0 1.0 3 P30536 1 +Activation of kainate receptors upon glutamate binding 0.4083811113472975 0.0953997376148898 0.923997324481985 1.0 1.0 4 P63218 1 +Visual phototransduction 0.3247587954818693 0.0951062553249911 0.9242304295700252 1.0 1.0 10 P49354,P53582 2 +Sensory processing of sound by outer hair cells of the cochlea 0.3162979121221593 0.0934166976845905 0.9255725256893514 1.0 1.0 12 Q00013,P23634,Q13813,P15311,P35579,O14936,Q6IBS0,Q9Y2J2,P26038,Q01082,P35241 11 +Extracellular matrix organization 0.2895662497197589 0.0925756129191095 0.9262407186010916 1.0 1.0 29 P13674,Q92542,Q9Y296,P05067,O15460,Q08722,P35613 7 +Chylomicron assembly 0.4895930413171656 0.0909592802736752 0.9275249465131916 1.0 1.0 2 P07237 1 +Plasma lipoprotein assembly remodeling and clearance 0.2958788420444448 0.0908007897385154 0.9276508825246506 1.0 1.0 19 Q9BU23,P61916,O15118,Q8WTV0 4 +Glycogen breakdown glycogenolysis 0.336441594384579 0.0907008151700771 0.927730322890962 1.0 1.0 8 P10253,P35573 2 +Other interleukin signaling 0.4863269111249306 0.0896502908767777 0.9285651189313832 1.0 1.0 3 Q12846,P40222 2 +Regulation of runx3 expression and activity 0.2886362267831881 0.0887285511680572 0.9292976414685944 1.0 1.0 37 P28072,P61289,P49721,O00231 4 +Arms mediated activation 0.4853946550652738 0.088351088669459 0.9295976347904428 1.0 1.0 3 Q9ULH0,P46108 2 +Ca dependent events 0.3504839754314284 0.0848361376177938 0.9323916634242936 1.0 1.0 6 P10644 1 +Notch2 intracellular domain regulates transcription 0.4790307548928116 0.0805509959998426 0.9357990390224944 1.0 1.0 2 Q04721 1 +Interaction between l1 and ankyrins 0.4748290863890775 0.074346148907622 0.9407349570914824 1.0 1.0 3 Q12955,Q13813 2 +Tnfr1 induced proapoptotic signaling 0.4694004349176621 0.072118271108543 0.9425077858439486 1.0 1.0 2 Q13546 1 +Defective ripk1 mediated regulated necrosis 0.4694004349176621 0.072118271108543 0.9425077858439486 1.0 1.0 2 Q13546 1 +Regulation by c flip 0.4695463020509798 0.0678334000665043 0.9459182555779102 1.0 1.0 3 Q13546,P49327 2 +Caspase activation via death receptors in the presence of ligand 0.4695463020509798 0.0678334000665043 0.9459182555779102 1.0 1.0 3 Q13546,P49327 2 +Degradation of axin 0.2855145402250981 0.0625407512014657 0.95013221067176 1.0 1.0 36 P28072,P61289,P49721,O00231 4 +Metabolism of polyamines 0.2841789166289184 0.0568713784939982 0.95464765405274 1.0 1.0 38 Q9UL46,P28072,P61289,P49721,O00231 5 +Response of eif2ak1 hri to heme deficiency 0.4580484773151137 0.0547596319581784 0.9563299611508178 1.0 1.0 3 P05198,P08243 2 +Platelet adhesion to exposed collagen 0.4311898105001531 0.0474558839007196 0.962149890241438 1.0 1.0 2 P05556 1 +G protein mediated events 0.3093601418177187 0.0460619255678571 0.9632608927743816 1.0 1.0 11 P50148,P10644,P52292,P04899 4 +The role of gtse1 in g2 m progression after g2 checkpoint 0.2754544554593248 0.0447444529428937 0.964311000834829 1.0 1.0 48 P28072,P61289,P04637,P49721,O00231 5 +Enos activation 0.4471721566190282 0.0437381725746031 0.96511311100387 1.0 1.0 3 P07900,P35270 2 +Sars cov 2 infection 0.2795121106570867 0.04362018578555 0.9652071610806808 1.0 1.0 23 P27824,Q16706,P46977,Q10472 4 +Assembly of the hiv virion 0.4187635911773765 0.0420176909004713 0.9664845952715608 1.0 1.0 2 Q9H9H4 1 +Lipophagy 0.3745725831520133 0.0383024520025299 0.9694465358072086 1.0 1.0 4 O60664,P54646,P54619 3 +Pre notch processing in the endoplasmic reticulum 0.4013668841255016 0.0361019303614356 0.9712010831269982 1.0 1.0 2 Q04721 1 +Inla mediated entry of listeria monocytogenes into host cells 0.4387818520820556 0.0360927546092042 0.9712083995497685 1.0 1.0 3 P35222,P12931 2 +Disinhibition of snare formation 0.4381603480422725 0.0355551915099083 0.9716370377058324 1.0 1.0 3 Q12846,P05771 2 +Role of lat2 ntal lab on calcium mobilization 0.4297700435052977 0.0286745859751384 0.9771241254848616 1.0 1.0 3 P07948,O00459 2 +Notch4 intracellular domain regulates transcription 0.417961466749544 0.0201307130828886 0.983939099608764 1.0 1.0 3 Q04721,Q06330 2 +Potential therapeutics for sars 0.2792838512627879 0.0194624489294948 0.9844721927783042 1.0 1.0 38 Q99720,P49354,P21964 3 +Aryl hydrocarbon receptor signalling 0.3990055935363644 0.0089672805114698 0.9928452412158584 1.0 1.0 3 O00170,Q15185 2 +Slc transporter disorders 0.2782723534907246 0.0078002325041688 0.993776378025604 1.0 1.0 33 Q9BTX1,O00400,Q8NFH5,Q9BW27,P53985,Q8N1F7,P35613,Q8NFH4,Q7Z3B4,Q99567 10 +Regulation of beta cell development 0.3503263910475619 0.007665204806867 0.9938841113194792 1.0 1.0 4 Q13573,P31751,Q06330 3 +Peroxisomal protein import 0.2798037903290018 0.0072389729895287 0.99422418566037 1.0 1.0 20 Q9BY49,P39210,O00116,O15254,O15228,O75381 6 +Sars cov infections 0.2514760404251303 0.0070157458070542 0.9944022906585904 1.0 1.0 61 P49354,Q10472,P05023,Q99720,P46977,P21964 6 +Signaling by retinoic acid 0.2960924447860999 0.0060219332595871 0.9951952214658332 1.0 1.0 12 Q8NBN7,P09622 2 +Interleukin receptor shc signaling 0.3847110006215199 0.0023934361897134 0.9980903160402436 1.0 1.0 3 O00459,P62993 2 +Pyroptosis 0.3190116084782071 0.0020192694318377 0.9983888571911276 1.0 1.0 6 Q9Y3E7,P04637 2 diff --git a/msigdb_reactome/selections.json b/msigdb_reactome/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..6a1f74799cdcefb888a3dd1103a4a7e4acda7761 --- /dev/null +++ b/msigdb_reactome/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["2 ltr circle formation", "A tetrasaccharide linker sequence is required for gag synthesis", "Abacavir metabolism", "Abacavir transmembrane transport", "Abacavir transport and metabolism", "Abc family proteins mediated transport", "Abc transporter disorders", "Abc transporters in lipid homeostasis", "Aberrant regulation of mitotic exit in cancer due to rb1 defects", "Aberrant regulation of mitotic g1 s transition in cancer due to rb1 defects", "Abortive elongation of hiv 1 transcript in the absence of tat", "Acetylcholine neurotransmitter release cycle", "Acetylcholine regulates insulin secretion", "Activated notch1 transmits signal to the nucleus", "Activated ntrk2 signals through cdk5", "Activated ntrk2 signals through frs2 and frs3", "Activated ntrk2 signals through fyn", "Activated ntrk2 signals through pi3k", "Activated ntrk2 signals through ras", "Activated ntrk3 signals through pi3k", "Activated ntrk3 signals through ras", "Activated pkn1 stimulates transcription of ar androgen receptor regulated genes klk2 and klk3", "Activated tak1 mediates p38 mapk activation", "Activation of ampk downstream of nmdars", "Activation of anterior hox genes in hindbrain development during early embryogenesis", "Activation of atr in response to replication stress", "Activation of bad and translocation to mitochondria", "Activation of bh3 only proteins", "Activation of gene expression by srebf srebp", "Activation of irf3 irf7 mediated by tbk1 ikk epsilon", "Activation of kainate receptors upon glutamate binding", "Activation of nima kinases nek9 nek6 nek7", "Activation of nmda receptors and postsynaptic events", "Activation of noxa and translocation to mitochondria", "Activation of ppargc1a pgc 1alpha by phosphorylation", "Activation of puma and translocation to mitochondria", "Activation of rac1", "Activation of rac1 downstream of nmdars", "Activation of smo", "Activation of the ap 1 family of transcription factors", "Activation of the mrna upon binding of the cap binding complex and eifs and subsequent binding to 43s", "Activation of the pre replicative complex", "Activation of the tfap2 ap 2 family of transcription factors", "Acyl chain remodeling of cl", "Acyl chain remodelling of pc", "Acyl chain remodelling of pe", "Acyl chain remodelling of pg", "Acyl chain remodelling of pi", "Acyl chain remodelling of ps", "Adaptive immune system", "Adenylate cyclase inhibitory pathway", "Adherens junctions interactions", "Adora2b mediated anti inflammatory cytokines production", "Adp signalling through p2y purinoceptor 1", "Adp signalling through p2y purinoceptor 12", "Adrenaline noradrenaline inhibits insulin secretion", "Advanced glycosylation endproduct receptor signaling", "Aflatoxin activation and detoxification", "Aggrephagy", "Akt phosphorylates targets in the cytosol", "Akt phosphorylates targets in the nucleus", "Alk mutants bind tkis", "Alpha linolenic omega3 and linoleic omega6 acid metabolism", "Alpha oxidation of phytanate", "Alpha protein kinase 1 signaling pathway", "Amino acid transport across the plasma membrane", "Amino acids regulate mtorc1", "Ampk inhibits chrebp transcriptional activation activity", "Amyloid fiber formation", "Anchoring of the basal body to the plasma membrane", "Androgen biosynthesis", "Anti inflammatory response favouring leishmania parasite infection", "Antigen activates b cell receptor bcr leading to generation of second messengers", "Antigen presentation folding assembly and peptide loading of class i mhc", "Antigen processing cross presentation", "Antigen processing ubiquitination proteasome degradation", "Antimicrobial peptides", "Antiviral mechanism by ifn stimulated genes", "Apc c cdc20 mediated degradation of cyclin b", "Apc c cdh1 mediated degradation of cdc20 and other apc c cdh1 targeted proteins in late mitosis early g1", "Apc c mediated degradation of cell cycle proteins", "Apc cdc20 mediated degradation of nek2a", "Apex1 independent resolution of ap sites via the single nucleotide replacement pathway", "Apobec3g mediated resistance to hiv 1 infection", "Apoptosis", "Apoptosis induced dna fragmentation", "Apoptotic cleavage of cell adhesion proteins", "Apoptotic cleavage of cellular proteins", "Apoptotic execution phase", "Apoptotic factor mediated response", "Aquaporin mediated transport", "Arachidonate production from dag", "Arachidonic acid metabolism", "Arms mediated activation", "Aryl hydrocarbon receptor signalling", "Asparagine n linked glycosylation", "Aspartate and asparagine metabolism", "Assembly and cell surface presentation of nmda receptors", "Assembly of active lpl and lipc lipase complexes", "Assembly of collagen fibrils and other multimeric structures", "Assembly of the hiv virion", "Assembly of the orc complex at the origin of replication", "Association of tric cct with target proteins during biosynthesis", "Asymmetric localization of pcp proteins", "Atf4 activates genes in response to endoplasmic reticulum stress", "Atf6 atf6 alpha activates chaperone genes", "Atf6 atf6 alpha activates chaperones", "Attachment and entry", "Attachment of gpi anchor to upar", "Attenuation phase", "Auf1 hnrnp d0 binds and destabilizes mrna", "Aurka activation by tpx2", "Autophagy", "B wich complex positively regulates rrna expression", "Base excision repair", "Base excision repair ap site formation", "Basigin interactions", "Bbsome mediated cargo targeting to cilium", "Beta catenin independent wnt signaling", "Beta catenin phosphorylation cascade", "Beta oxidation of butanoyl coa to acetyl coa", "Beta oxidation of decanoyl coa to octanoyl coa coa", "Beta oxidation of hexanoyl coa to butanoyl coa", "Beta oxidation of lauroyl coa to decanoyl coa coa", "Beta oxidation of octanoyl coa to hexanoyl coa", "Beta oxidation of pristanoyl coa", "Beta oxidation of very long chain fatty acids", "Bh3 only proteins associate with and inactivate anti apoptotic bcl 2 members", "Bicarbonate transporters", "Bile acid and bile salt metabolism", "Binding and uptake of ligands by scavenger receptors", "Binding of tcf lef ctnnb1 to target gene promoters", "Biological oxidations", "Biosynthesis of epa derived spms", "Biosynthesis of maresins", "Biosynthesis of specialized proresolving mediators spms", "Biosynthesis of the n glycan precursor dolichol lipid linked oligosaccharide llo and transfer to a nascent protein", "Biotin transport and metabolism", "Bmal1 clock npas2 activates circadian gene expression", "Branched chain amino acid catabolism", "Budding and maturation of hiv virion", "Butyrate response factor 1 brf1 binds and destabilizes mrna", "C type lectin receptors clrs", "Ca dependent events", "Ca2 pathway", "Calcineurin activates nfat", "Calnexin calreticulin cycle", "Camk iv mediated phosphorylation of creb", "Carboxyterminal post translational modifications of tubulin", "Cardiac conduction", "Cargo concentration in the er", "Cargo recognition for clathrin mediated endocytosis", "Cargo trafficking to the periciliary membrane", "Carnitine metabolism", "Caspase activation via death receptors in the presence of ligand", "Caspase activation via dependence receptors in the absence of ligand", "Caspase activation via extrinsic apoptotic signalling pathway", "Caspase mediated cleavage of cytoskeletal proteins", "Cation coupled chloride cotransporters", "Cd163 mediating an anti inflammatory response", "Cd209 dc sign signaling", "Cd22 mediated bcr regulation", "Cd28 co stimulation", "Cd28 dependent pi3k akt signaling", "Cd28 dependent vav1 pathway", "Cdc42 gtpase cycle", "Cdc6 association with the orc origin complex", "Cdt1 association with the cdc6 orc origin complex", "Cell cell communication", "Cell cell junction organization", "Cell cycle", "Cell cycle checkpoints", "Cell cycle mitotic", "Cell death signalling via nrage nrif and nade", "Cell extracellular matrix interactions", "Cell junction organization", "Cell surface interactions at the vascular wall", "Cellular response to chemical stress", "Cellular response to heat stress", "Cellular response to hypoxia", "Cellular response to starvation", "Cellular responses to stimuli", "Cellular senescence", "Chaperone mediated autophagy", "Chk1 chk2 cds1 mediated inactivation of cyclin b cdk1 complex", "Chl1 interactions", "Cholesterol biosynthesis", "Choline catabolism", "Chondroitin sulfate biosynthesis", "Chondroitin sulfate dermatan sulfate metabolism", "Chrebp activates metabolic gene expression", "Chromatin modifying enzymes", "Chromosome maintenance", "Chylomicron assembly", "Chylomicron clearance", "Cilium assembly", "Circadian clock", "Citric acid cycle tca cycle", "Class a 1 rhodopsin like receptors", "Class b 2 secretin family receptors", "Class i mhc mediated antigen processing presentation", "Class i peroxisomal membrane protein import", "Clathrin mediated endocytosis", "Clec7a dectin 1 induces nfat activation", "Clec7a dectin 1 signaling", "Clec7a inflammasome pathway", "Cobalamin cbl vitamin b12 transport and metabolism", "Coenzyme a biosynthesis", "Cohesin loading onto chromatin", "Collagen biosynthesis and modifying enzymes", "Collagen formation", "Competing endogenous rnas cernas regulate pten translation", "Complement cascade", "Complex i biogenesis", "Condensation of prometaphase chromosomes", "Condensation of prophase chromosomes", "Constitutive signaling by aberrant pi3k in cancer", "Constitutive signaling by akt1 e17k in cancer", "Constitutive signaling by egfrviii", "Constitutive signaling by ligand responsive egfr cancer variants", "Constitutive signaling by overexpressed erbb2", "Conversion from apc c cdc20 to apc c cdh1 in late anaphase", "Cooperation of pdcl phlp1 and tric cct in g protein beta folding", "Cooperation of prefoldin and tric cct in actin and tubulin folding", "Copi dependent golgi to er retrograde traffic", "Copi independent golgi to er retrograde traffic", "Copi mediated anterograde transport", "Copii mediated vesicle transport", "Costimulation by the cd28 family", "Creatine metabolism", "Creb phosphorylation", "Creb1 phosphorylation through nmda receptor mediated activation of ras signaling", "Creb1 phosphorylation through the activation of adenylate cyclase", "Creb1 phosphorylation through the activation of camkii camkk camkiv cascasde", "Cristae formation", "Crmps in sema3a signaling", "Cross presentation of soluble exogenous antigens endosomes", "Cs ds degradation", "Ctla4 inhibitory signaling", "Cyclin a b1 b2 associated events during g2 m transition", "Cyclin a cdk2 associated events at s phase entry", "Cyclin d associated events in g1", "Cytochrome c mediated apoptotic response", "Cytochrome p450 arranged by substrate type", "Cytokine signaling in immune system", "Cytoprotection by hmox1", "Cytosolic iron sulfur cluster assembly", "Cytosolic sensors of pathogen associated dna", "Cytosolic sulfonation of small molecules", "Cytosolic trna aminoacylation", "Dag and ip3 signaling", "Dap12 interactions", "Dap12 signaling", "Darpp 32 events", "Dcc mediated attractive signaling", "Ddx58 ifih1 mediated induction of interferon alpha beta", "Deactivation of the beta catenin transactivating complex", "Deadenylation dependent mrna decay", "Deadenylation of mrna", "Death receptor signalling", "Dectin 1 mediated noncanonical nf kb signaling", "Dectin 2 family", "Defective cftr causes cystic fibrosis", "Defective chst14 causes eds musculocontractural type", "Defective factor ix causes hemophilia b", "Defective intrinsic pathway for apoptosis", "Defective lfng causes scdo3", "Defective ripk1 mediated regulated necrosis", "Defects in biotin btn metabolism", "Defects in cobalamin b12 metabolism", "Defects in vitamin and cofactor metabolism", "Defects of contact activation system cas and kallikrein kinin system kks", "Degradation of axin", "Degradation of beta catenin by the destruction complex", "Degradation of cysteine and homocysteine", "Degradation of dvl", "Degradation of gli1 by the proteasome", "Degradation of the extracellular matrix", "Depolymerisation of the nuclear lamina", "Deposition of new cenpa containing nucleosomes at the centromere", "Dermatan sulfate biosynthesis", "Detoxification of reactive oxygen species", "Deubiquitination", "Developmental biology", "Dex h box helicases activate type i ifn and inflammatory cytokines production", "Digestion", "Digestion and absorption", "Disassembly of the destruction complex and recruitment of axin to the membrane", "Diseases associated with glycosaminoglycan metabolism", "Diseases associated with glycosylation precursor biosynthesis", "Diseases associated with n glycosylation of proteins", "Diseases associated with o glycosylation of proteins", "Diseases of base excision repair", "Diseases of carbohydrate metabolism", "Diseases of dna repair", "Diseases of glycosylation", "Diseases of immune system", "Diseases of metabolism", "Diseases of mismatch repair mmr", "Diseases of mitotic cell cycle", "Diseases of programmed cell death", "Diseases of signal transduction by growth factor receptors and second messengers", "Disinhibition of snare formation", "Disorders of transmembrane transporters", "Displacement of dna glycosylase by apex1", "Dissolution of fibrin clot", "Dna damage bypass", "Dna damage recognition in gg ner", "Dna damage reversal", "Dna damage telomere stress induced senescence", "Dna double strand break repair", "Dna double strand break response", "Dna methylation", "Dna repair", "Dna replication", "Dna replication initiation", "Dna replication pre initiation", "Dna strand elongation", "Dopamine clearance from the synaptic cleft", "Dopamine neurotransmitter release cycle", "Downregulation of erbb2 erbb3 signaling", "Downregulation of erbb2 signaling", "Downregulation of erbb4 signaling", "Downregulation of smad2 3 smad4 transcriptional activity", "Downregulation of tgf beta receptor signaling", "Downstream signal transduction", "Downstream signaling events of b cell receptor bcr", "Downstream signaling of activated fgfr1", "Downstream signaling of activated fgfr2", "Downstream signaling of activated fgfr3", "Downstream signaling of activated fgfr4", "Dscam interactions", "Dual incision in gg ner", "Dual incision in tc ner", "E2f enabled inhibition of pre replication complex formation", "E2f mediated regulation of dna replication", "E3 ubiquitin ligases ubiquitinate target proteins", "Early phase of hiv life cycle", "Ecm proteoglycans", "Effects of pip2 hydrolysis", "Egfr downregulation", "Egfr interacts with phospholipase c gamma", "Egfr transactivation by gastrin", "Egr2 and sox10 mediated initiation of schwann cell myelination", "Elastic fibre formation", "Endogenous sterols", "Endosomal sorting complex required for transport escrt", "Endosomal vacuolar pathway", "Energy dependent regulation of mtor by lkb1 ampk", "Enos activation", "Eph ephrin mediated repulsion of cells", "Eph ephrin signaling", "Epha mediated growth cone collapse", "Ephb mediated forward signaling", "Ephrin signaling", "Epigenetic regulation of gene expression", "Er quality control compartment erqc", "Er to golgi anterograde transport", "Erbb2 regulates cell motility", "Ercc6 csb and ehmt2 g9a positively regulate rrna expression", "Erk mapk targets", "Erks are inactivated", "Erythrocytes take up carbon dioxide and release oxygen", "Erythropoietin activates phosphoinositide 3 kinase pi3k", "Erythropoietin activates phospholipase c gamma plcg", "Erythropoietin activates ras", "Erythropoietin activates stat5", "Esr mediated signaling", "Establishment of sister chromatid cohesion", "Estrogen biosynthesis", "Estrogen dependent gene expression", "Estrogen dependent nuclear events downstream of esr membrane signaling", "Estrogen stimulated signaling through prkcz", "Ethanol oxidation", "Eukaryotic translation elongation", "Eukaryotic translation initiation", "Export of viral ribonucleoproteins from nucleus", "Extension of telomeres", "Extra nuclear estrogen signaling", "Extracellular matrix organization", "Factors involved in megakaryocyte development and platelet production", "Fanconi anemia pathway", "Fasl cd95l signaling", "Fatty acid metabolism", "Fatty acids bound to gpr40 ffar1 regulate insulin secretion", "Fatty acyl coa biosynthesis", "Fbxw7 mutants and notch1 in cancer", "Fc epsilon receptor fceri signaling", "Fceri mediated ca 2 mobilization", "Fceri mediated mapk activation", "Fceri mediated nf kb activation", "Fcgamma receptor fcgr dependent phagocytosis", "Fcgr activation", "Fcgr3a mediated il10 synthesis", "Fgfr1 mutant receptor activation", "Fgfr2 alternative splicing", "Fgfr2 mutant receptor activation", "Fibronectin matrix formation", "Flt3 signaling", "Flt3 signaling in disease", "Folding of actin by cct tric", "Formation of apoptosome", "Formation of atp by chemiosmotic coupling", "Formation of fibrin clot clotting cascade", "Formation of incision complex in gg ner", "Formation of rna pol ii elongation complex", "Formation of senescence associated heterochromatin foci sahf", "Formation of tc ner pre incision complex", "Formation of the beta catenin tcf transactivating complex", "Formation of the cornified envelope", "Formation of the early elongation complex", "Formation of tubulin folding intermediates by cct tric", "Formation of xylulose 5 phosphate", "Formyl peptide receptors bind formyl peptides and many other ligands", "Foxo mediated transcription", "Foxo mediated transcription of oxidative stress metabolic and neuronal genes", "Free fatty acids regulate insulin secretion", "Frs mediated fgfr1 signaling", "Frs mediated fgfr2 signaling", "Frs mediated fgfr3 signaling", "Frs mediated fgfr4 signaling", "Fructose metabolism", "G alpha 12 13 signalling events", "G alpha i signalling events", "G alpha q signalling events", "G alpha s signalling events", "G alpha z signalling events", "G beta gamma signalling through cdc42", "G beta gamma signalling through pi3kgamma", "G protein activation", "G protein beta gamma signalling", "G protein mediated events", "G0 and early g1", "G1 s dna damage checkpoints", "G1 s specific transcription", "G2 m checkpoints", "G2 m dna damage checkpoint", "G2 m dna replication checkpoint", "G2 phase", "Gab1 signalosome", "Gaba b receptor activation", "Gaba receptor activation", "Gaba synthesis release reuptake and degradation", "Galactose catabolism", "Gamma carboxylation hypusine formation and arylsulfatase activation", "Gamma carboxylation transport and amino terminal cleavage of proteins", "Gap filling dna repair synthesis and ligation in gg ner", "Gap junction assembly", "Gap junction degradation", "Gap junction trafficking and regulation", "Gastrin creb signalling pathway via pkc and mapk", "Gene and protein expression by jak stat signaling after interleukin 12 stimulation", "Gene silencing by rna", "Generation of second messenger molecules", "Global genome nucleotide excision repair gg ner", "Glucagon like peptide 1 glp1 regulates insulin secretion", "Glucagon signaling in metabolic regulation", "Glucagon type ligand receptors", "Gluconeogenesis", "Glucose metabolism", "Glucuronidation", "Glutamate and glutamine metabolism", "Glutamate neurotransmitter release cycle", "Glutathione conjugation", "Glutathione synthesis and recycling", "Glycerophospholipid biosynthesis", "Glycerophospholipid catabolism", "Glycogen breakdown glycogenolysis", "Glycogen metabolism", "Glycogen storage diseases", "Glycogen synthesis", "Glycolysis", "Glycosaminoglycan metabolism", "Glycosphingolipid metabolism", "Glyoxylate metabolism and glycine degradation", "Golgi associated vesicle biogenesis", "Golgi cisternae pericentriolar stack reorganization", "Golgi to er retrograde transport", "Gp1b ix v activation signalling", "Gpcr ligand binding", "Gpvi mediated activation cascade", "Grb2 events in erbb2 signaling", "Grb2 sos provides linkage to mapk signaling for integrins", "Growth hormone receptor signaling", "Hats acetylate histones", "Hcmv early events", "Hcmv infection", "Hcmv late events", "Hdacs deacetylate histones", "Hdl assembly", "Hdl clearance", "Hdms demethylate histones", "Hdr through homologous recombination hrr", "Hdr through mmej alt nhej", "Hdr through single strand annealing ssa", "Hedgehog ligand biogenesis", "Hedgehog off state", "Hedgehog on state", "Heme biosynthesis", "Heme degradation", "Heme signaling", "Hemostasis", "Heparan sulfate heparin hs gag metabolism", "Hiv elongation arrest and recovery", "Hiv infection", "Hiv life cycle", "Hiv transcription elongation", "Hiv transcription initiation", "Homologous dna pairing and strand exchange", "Homology directed repair", "Host interactions of hiv factors", "Hs gag biosynthesis", "Hs gag degradation", "Hsf1 activation", "Hsf1 dependent transactivation", "Hsp90 chaperone cycle for steroid hormone receptors shr in the presence of ligand", "Hur elavl1 binds and stabilizes mrna", "Hyaluronan metabolism", "Hyaluronan uptake and degradation", "Hydrolysis of lpc", "Ikba variant leads to eda id", "Ikk complex recruitment mediated by rip1", "Immunoregulatory interactions between a lymphoid and a non lymphoid cell", "Inactivation of cdc42 and rac1", "Inactivation of csf3 g csf signaling", "Incretin synthesis secretion and inactivation", "Infection with mycobacterium tuberculosis", "Infectious disease", "Inflammasomes", "Influenza infection", "Inhibition of dna recombination at telomere", "Inhibition of replication initiation of damaged dna by rb1 e2f1", "Inhibition of the proteolytic activity of apc c required for the onset of anaphase by mitotic spindle checkpoint components", "Initiation of nuclear envelope ne reformation", "Inla mediated entry of listeria monocytogenes into host cells", "Inlb mediated entry of listeria monocytogenes into host cell", "Innate immune system", "Inositol phosphate metabolism", "Insertion of tail anchored proteins into the endoplasmic reticulum membrane", "Insulin processing", "Insulin receptor recycling", "Insulin receptor signalling cascade", "Integration of energy metabolism", "Integration of provirus", "Integrin cell surface interactions", "Integrin signaling", "Interaction between l1 and ankyrins", "Interactions of rev with host cellular proteins", "Interactions of vpr with host cellular proteins", "Interconversion of nucleotide di and triphosphates", "Interferon alpha beta signaling", "Interferon gamma signaling", "Interferon signaling", "Interleukin 1 family signaling", "Interleukin 1 signaling", "Interleukin 10 signaling", "Interleukin 12 family signaling", "Interleukin 12 signaling", "Interleukin 15 signaling", "Interleukin 17 signaling", "Interleukin 2 family signaling", "Interleukin 20 family signaling", "Interleukin 21 signaling", "Interleukin 23 signaling", "Interleukin 27 signaling", "Interleukin 3 interleukin 5 and gm csf signaling", "Interleukin 35 signalling", "Interleukin 37 signaling", "Interleukin 4 and interleukin 13 signaling", "Interleukin 6 family signaling", "Interleukin 6 signaling", "Interleukin 7 signaling", "Interleukin 9 signaling", "Interleukin receptor shc signaling", "Intra golgi and retrograde golgi to er traffic", "Intra golgi traffic", "Intracellular signaling by second messengers", "Intraflagellar transport", "Intrinsic pathway for apoptosis", "Intrinsic pathway of fibrin clot formation", "Inwardly rectifying k channels", "Ion channel transport", "Ion homeostasis", "Ion transport by p type atpases", "Ionotropic activity of kainate receptors", "Irak1 recruits ikk complex", "Irak2 mediated activation of tak1 complex", "Irak4 deficiency tlr2 4", "Ire1alpha activates chaperones", "Irf3 mediated activation of type 1 ifn", "Irf3 mediated induction of type i ifn", "Iron uptake and transport", "Irs mediated signalling", "Jnk c jun kinases phosphorylation and activation mediated by activated human tak1", "Josephin domain dubs", "Keratan sulfate biosynthesis", "Keratan sulfate degradation", "Keratan sulfate keratin metabolism", "Keratinization", "Ketone body metabolism", "Killing mechanisms", "Kinesins", "Ksrp khsrp binds and destabilizes mrna", "L1cam interactions", "Lagging strand synthesis", "Laminin interactions", "Late endosomal microautophagy", "Ldl clearance", "Ldl remodeling", "Leishmania infection", "Lgi adam interactions", "Linoleic acid la metabolism", "Lipophagy", "Listeria monocytogenes entry into host cells", "Long term potentiation", "Loss of function of mecp2 in rett syndrome", "Loss of mecp2 binding ability to the ncor smrt complex", "Lrr flii interacting protein 1 lrrfip1 activates type i ifn production", "Lysine catabolism", "Lysosome vesicle biogenesis", "M phase", "Map2k and mapk activation", "Map3k8 tpl2 dependent mapk1 3 activation", "Mapk family signaling cascades", "Mapk targets nuclear events mediated by map kinases", "Mapk1 erk2 activation", "Mapk3 erk1 activation", "Mapk6 mapk4 signaling", "Mastl facilitates mitotic progression", "Maturation of protein 3a", "Maturation of sars cov 1 nucleoprotein", "Maturation of sars cov 1 spike protein", "Maturation of sars cov 2 nucleoprotein", "Maturation of sars cov 2 spike protein", "Mecp2 regulates neuronal receptors and channels", "Mecp2 regulates transcription factors", "Mecp2 regulates transcription of neuronal ligands", "Meiosis", "Meiotic recombination", "Meiotic synapsis", "Membrane trafficking", "Met activates pi3k akt signaling", "Met activates ptk2 signaling", "Met activates ptpn11", "Met activates rap1 and rac1", "Met activates ras signaling", "Met interacts with tns proteins", "Met promotes cell motility", "Met receptor recycling", "Metabolic disorders of biological oxidation enzymes", "Metabolism of amino acids and derivatives", "Metabolism of angiotensinogen to angiotensins", "Metabolism of carbohydrates", "Metabolism of cofactors", "Metabolism of fat soluble vitamins", "Metabolism of folate and pterines", "Metabolism of ingested semet sec mesec into h2se", "Metabolism of lipids", "Metabolism of nitric oxide nos3 activation and regulation", "Metabolism of nucleotides", "Metabolism of polyamines", "Metabolism of porphyrins", "Metabolism of rna", "Metabolism of steroid hormones", "Metabolism of steroids", "Metabolism of vitamins and cofactors", "Metabolism of water soluble vitamins and cofactors", "Metal ion slc transporters", "Metalloprotease dubs", "Methionine salvage pathway", "Methylation", "Mhc class ii antigen presentation", "Microrna mirna biogenesis", "Miro gtpase cycle", "Miscellaneous transport and binding events", "Mismatch repair", "Mitochondrial biogenesis", "Mitochondrial calcium ion transport", "Mitochondrial fatty acid beta oxidation", "Mitochondrial fatty acid beta oxidation of saturated fatty acids", "Mitochondrial fatty acid beta oxidation of unsaturated fatty acids", "Mitochondrial iron sulfur cluster biogenesis", "Mitochondrial protein import", "Mitochondrial translation", "Mitochondrial trna aminoacylation", "Mitophagy", "Mitotic g1 phase and g1 s transition", "Mitotic g2 g2 m phases", "Mitotic metaphase and anaphase", "Mitotic prometaphase", "Mitotic prophase", "Mitotic spindle checkpoint", "Mitotic telophase cytokinesis", "Molecules associated with elastic fibres", "Molybdenum cofactor biosynthesis", "Mrna capping", "Mrna decay by 3 to 5 exoribonuclease", "Mrna decay by 5 to 3 exoribonuclease", "Mrna editing", "Mrna splicing", "Mrna splicing minor pathway", "Mtor signalling", "Mtorc1 mediated signalling", "Mucopolysaccharidoses", "Muscle contraction", "Myd88 independent tlr4 cascade", "Myoclonic epilepsy of lafora", "Myogenesis", "N glycan antennae elongation in the medial trans golgi", "N glycan trimming in the er and calnexin calreticulin cycle", "Nade modulates death signalling", "Ncam signaling for neurite out growth", "Neddylation", "Nef and signal transduction", "Nef mediated cd4 down regulation", "Nef mediated cd8 down regulation", "Nef mediated downregulation of mhc class i complex cell surface expression", "Nef mediates down modulation of cell surface receptors by recruiting them to clathrin adapters", "Negative epigenetic regulation of rrna expression", "Negative feedback regulation of mapk pathway", "Negative regulation of fgfr1 signaling", "Negative regulation of fgfr2 signaling", "Negative regulation of fgfr3 signaling", "Negative regulation of fgfr4 signaling", "Negative regulation of flt3", "Negative regulation of mapk pathway", "Negative regulation of met activity", "Negative regulation of nmda receptor mediated neuronal transmission", "Negative regulation of notch4 signaling", "Negative regulation of the pi3k akt network", "Negative regulators of ddx58 ifih1 signaling", "Nephrin family interactions", "Nervous system development", "Netrin 1 signaling", "Netrin mediated repulsion signals", "Neurexins and neuroligins", "Neuronal system", "Neurotoxicity of clostridium toxins", "Neurotransmitter clearance", "Neurotransmitter receptors and postsynaptic signal transmission", "Neurotransmitter release cycle", "Neutrophil degranulation", "Nf kb activation through fadd rip 1 pathway mediated by caspase 8 and 10", "Nf kb is activated and signals survival", "Ngf stimulated transcription", "Nicotinamide salvaging", "Nicotinate metabolism", "Nod1 2 signaling pathway", "Non integrin membrane ecm interactions", "Noncanonical activation of notch3", "Nonhomologous end joining nhej", "Nonsense mediated decay nmd", "Norepinephrine neurotransmitter release cycle", "Nostrin mediated enos trafficking", "Notch hlh transcription pathway", "Notch1 intracellular domain regulates transcription", "Notch2 activation and transmission of signal to the nucleus", "Notch2 intracellular domain regulates transcription", "Notch3 activation and transmission of signal to the nucleus", "Notch3 intracellular domain regulates transcription", "Notch4 activation and transmission of signal to the nucleus", "Notch4 intracellular domain regulates transcription", "Nr1h2 and nr1h3 mediated signaling", "Nr1h2 nr1h3 regulate gene expression linked to lipogenesis", "Nr1h2 nr1h3 regulate gene expression to control bile acid homeostasis", "Nr1h3 nr1h2 regulate gene expression linked to cholesterol transport and efflux", "Nrage signals death through jnk", "Nrcam interactions", "Nrif signals cell death from the nucleus", "Ns1 mediated effects on host pathways", "Ntrk2 activates rac1", "Nuclear envelope breakdown", "Nuclear envelope ne reassembly", "Nuclear events kinase and transcription factor activation", "Nuclear events stimulated by alk signaling in cancer", "Nuclear import of rev protein", "Nuclear pore complex npc disassembly", "Nuclear receptor transcription pathway", "Nuclear signaling by erbb4", "Nucleotide binding domain leucine rich repeat containing receptor nlr signaling pathways", "Nucleotide biosynthesis", "Nucleotide catabolism", "Nucleotide excision repair", "Nucleotide salvage", "O linked glycosylation", "O linked glycosylation of mucins", "Oas antiviral response", "Oncogene induced senescence", "Oncogenic mapk signaling", "Opioid signalling", "Orc1 removal from chromatin", "Organelle biogenesis and maintenance", "Organic anion transporters", "Other interleukin signaling", "Other semaphorin interactions", "Ovarian tumor domain proteases", "Oxidative stress induced senescence", "P130cas linkage to mapk signaling for integrins", "P38mapk events", "P75 ntr receptor mediated signalling", "P75ntr negatively regulates cell cycle via sc1", "P75ntr recruits signalling complexes", "P75ntr regulates axonogenesis", "P75ntr signals via nf kb", "Parasite infection", "Passive transport by aquaporins", "Pcna dependent long patch base excision repair", "Pcp ce pathway", "Pd 1 signaling", "Pecam1 interactions", "Pentose phosphate pathway", "Peptide hormone metabolism", "Peptide ligand binding receptors", "Perk regulates gene expression", "Peroxisomal lipid metabolism", "Peroxisomal protein import", "Phase 0 rapid depolarisation", "Phase 2 plateau phase", "Phase 3 rapid repolarisation", "Phase i functionalization of compounds", "Phase ii conjugation of compounds", "Phenylalanine and tyrosine metabolism", "Phenylalanine metabolism", "Phosphate bond hydrolysis by nudt proteins", "Phospholipase c mediated cascade fgfr2", "Phospholipase c mediated cascade fgfr4", "Phospholipid metabolism", "Phosphorylation of emi1", "Phosphorylation of the apc c", "Pi 3k cascade fgfr1", "Pi 3k cascade fgfr2", "Pi 3k cascade fgfr3", "Pi 3k cascade fgfr4", "Pi metabolism", "Pi3k akt activation", "Pi3k akt signaling in cancer", "Pi3k events in erbb2 signaling", "Pi5p regulates tp53 acetylation", "Pink1 prkn mediated mitophagy", "Piwi interacting rna pirna biogenesis", "Pka activation in glucagon signalling", "Pka mediated phosphorylation of creb", "Pka mediated phosphorylation of key metabolic factors", "Pkmts methylate histone lysines", "Plasma lipoprotein assembly", "Plasma lipoprotein assembly remodeling and clearance", "Plasma lipoprotein clearance", "Plasma lipoprotein remodeling", "Platelet activation signaling and aggregation", "Platelet adhesion to exposed collagen", "Platelet aggregation plug formation", "Platelet calcium homeostasis", "Platelet homeostasis", "Platelet sensitization by ldl", "Polb dependent long patch base excision repair", "Polo like kinase mediated events", "Polymerase switching", "Polymerase switching on the c strand of the telomere", "Positive epigenetic regulation of rrna expression", "Post chaperonin tubulin folding pathway", "Post translational modification synthesis of gpi anchored proteins", "Post translational protein modification", "Postmitotic nuclear pore complex npc reformation", "Potassium channels", "Potential therapeutics for sars", "Pou5f1 oct4 sox2 nanog activate genes related to proliferation", "Pp2a mediated dephosphorylation of key metabolic factors", "Prc2 methylates histones and dna", "Pre notch expression and processing", "Pre notch processing in golgi", "Pre notch processing in the endoplasmic reticulum", "Pregnenolone biosynthesis", "Presynaptic function of kainate receptors", "Prevention of phagosomal lysosomal fusion", "Processing and activation of sumo", "Processing of capped intron containing pre mrna", "Processing of capped intronless pre mrna", "Processing of dna double strand break ends", "Processing of intronless pre mrnas", "Processing of smdt1", "Processive synthesis on the c strand of the telomere", "Processive synthesis on the lagging strand", "Programmed cell death", "Prolactin receptor signaling", "Prolonged erk activation events", "Propionyl coa catabolism", "Prostacyclin signalling through prostacyclin receptor", "Protein folding", "Protein localization", "Protein methylation", "Protein protein interactions at synapses", "Protein repair", "Protein ubiquitination", "Proton coupled monocarboxylate transport", "Pten regulation", "Ptk6 expression", "Ptk6 regulates cell cycle", "Ptk6 regulates proteins involved in rna processing", "Ptk6 regulates rho gtpases ras gtpase and map kinases", "Purine catabolism", "Purine ribonucleoside monophosphate biosynthesis", "Purine salvage", "Purinergic signaling in leishmaniasis infection", "Pyrimidine catabolism", "Pyrimidine salvage", "Pyroptosis", "Pyruvate metabolism", "Pyruvate metabolism and citric acid tca cycle", "Ra biosynthesis pathway", "Rab gefs exchange gtp for gdp on rabs", "Rab geranylgeranylation", "Rab regulation of trafficking", "Rac1 gtpase cycle", "Rac2 gtpase cycle", "Rac3 gtpase cycle", "Raf activation", "Raf independent mapk1 3 activation", "Rap1 signalling", "Ras activation upon ca2 influx through nmda receptor", "Ras processing", "Ras signaling downstream of nf1 loss of function variants", "Reactions specific to the complex n glycan synthesis pathway", "Receptor mediated mitophagy", "Receptor type tyrosine protein phosphatases", "Recognition and association of dna glycosylase with site containing an affected purine", "Recognition of dna damage by pcna containing replication complex", "Recruitment of mitotic centrosome proteins and complexes", "Recruitment of numa to mitotic centrosomes", "Recycling of eif2 gdp", "Recycling pathway of l1", "Reduction of cytosolic ca levels", "Regulated necrosis", "Regulated proteolysis of p75ntr", "Regulation by c flip", "Regulation of bach1 activity", "Regulation of beta cell development", "Regulation of cholesterol biosynthesis by srebp srebf", "Regulation of commissural axon pathfinding by slit and robo", "Regulation of cytoskeletal remodeling and cell spreading by ipp complex components", "Regulation of expression of slits and robos", "Regulation of gene expression in beta cells", "Regulation of gene expression in early pancreatic precursor cells", "Regulation of gene expression in late stage branching morphogenesis pancreatic bud precursor cells", "Regulation of glucokinase by glucokinase regulatory protein", "Regulation of glycolysis by fructose 2 6 bisphosphate metabolism", "Regulation of hmox1 expression and activity", "Regulation of hsf1 mediated heat shock response", "Regulation of ifna signaling", "Regulation of ifng signaling", "Regulation of innate immune responses to cytosolic dna", "Regulation of insulin like growth factor igf transport and uptake by insulin like growth factor binding proteins igfbps", "Regulation of insulin secretion", "Regulation of kit signaling", "Regulation of lipid metabolism by pparalpha", "Regulation of localization of foxo transcription factors", "Regulation of mecp2 expression and activity", "Regulation of mrna stability by proteins that bind au rich elements", "Regulation of plk1 activity at g2 m transition", "Regulation of pten gene transcription", "Regulation of pten localization", "Regulation of pten mrna translation", "Regulation of pten stability and activity", "Regulation of pyruvate dehydrogenase pdh complex", "Regulation of ras by gaps", "Regulation of runx1 expression and activity", "Regulation of runx2 expression and activity", "Regulation of runx3 expression and activity", "Regulation of signaling by cbl", "Regulation of tlr by endogenous ligand", "Regulation of tnfr1 signaling", "Regulation of tp53 activity", "Regulation of tp53 activity through acetylation", "Regulation of tp53 activity through association with co factors", "Regulation of tp53 activity through methylation", "Regulation of tp53 activity through phosphorylation", "Regulation of tp53 expression and degradation", "Repression of wnt target genes", "Reproduction", "Resolution of abasic sites ap sites", "Resolution of ap sites via the multiple nucleotide patch replacement pathway", "Resolution of d loop structures", "Resolution of d loop structures through synthesis dependent strand annealing sdsa", "Resolution of sister chromatid cohesion", "Respiratory electron transport", "Respiratory electron transport atp synthesis by chemiosmotic coupling and heat production by uncoupling proteins", "Response of eif2ak1 hri to heme deficiency", "Response of eif2ak4 gcn2 to amino acid deficiency", "Response of mtb to phagocytosis", "Response to elevated platelet cytosolic ca2", "Ret signaling", "Retrograde neurotrophin signalling", "Retrograde transport at the trans golgi network", "Rho gtpase cycle", "Rho gtpase effectors", "Rho gtpases activate cit", "Rho gtpases activate formins", "Rho gtpases activate iqgaps", "Rho gtpases activate ktn1", "Rho gtpases activate nadph oxidases", "Rho gtpases activate paks", "Rho gtpases activate pkns", "Rho gtpases activate rocks", "Rho gtpases activate wasps and waves", "Rhoa gtpase cycle", "Rhob gtpase cycle", "Rhobtb gtpase cycle", "Rhobtb1 gtpase cycle", "Rhobtb2 gtpase cycle", "Rhobtb3 atpase cycle", "Rhoc gtpase cycle", "Rhod gtpase cycle", "Rhof gtpase cycle", "Rhog gtpase cycle", "Rhoh gtpase cycle", "Rhoj gtpase cycle", "Rhoq gtpase cycle", "Rhot1 gtpase cycle", "Rhou gtpase cycle", "Rhov gtpase cycle", "Rip mediated nfkb activation via zbp1", "Ripk1 mediated regulated necrosis", "Rmts methylate histone arginines", "Rna polymerase i promoter escape", "Rna polymerase i transcription", "Rna polymerase i transcription initiation", "Rna polymerase i transcription termination", "Rna polymerase ii transcribes snrna genes", "Rna polymerase ii transcription", "Rna polymerase ii transcription termination", "Rna polymerase iii chain elongation", "Rna polymerase iii transcription", "Rna polymerase iii transcription initiation from type 1 promoter", "Rna polymerase iii transcription initiation from type 3 promoter", "Rna polymerase iii transcription termination", "Rnd1 gtpase cycle", "Rnd2 gtpase cycle", "Rnd3 gtpase cycle", "Robo receptors bind akap5", "Role of abl in robo slit signaling", "Role of lat2 ntal lab on calcium mobilization", "Role of phospholipids in phagocytosis", "Role of second messengers in netrin 1 signaling", "Rora activates gene expression", "Ros and rns production in phagocytes", "Rrna modification in the mitochondrion", "Rrna modification in the nucleus and cytosol", "Rrna processing", "Rrna processing in the mitochondrion", "Rsk activation", "Runx1 interacts with co factors whose precise effect on runx1 targets is not known", "Runx1 regulates estrogen receptor mediated transcription", "Runx1 regulates expression of components of tight junctions", "Runx1 regulates genes involved in megakaryocyte differentiation and platelet function", "Runx1 regulates transcription of genes involved in differentiation of hscs", "Runx1 regulates transcription of genes involved in differentiation of myeloid cells", "Runx2 regulates bone development", "Runx2 regulates genes involved in cell migration", "Runx2 regulates osteoblast differentiation", "Runx3 regulates cdkn1a transcription", "Runx3 regulates notch signaling", "Runx3 regulates p14 arf", "Runx3 regulates wnt signaling", "S phase", "Sars cov 1 infection", "Sars cov 2 infection", "Sars cov infections", "Scavenging by class a receptors", "Scavenging by class b receptors", "Scavenging by class f receptors", "Scavenging of heme from plasma", "Scf skp2 mediated degradation of p27 p21", "Sealing of the nuclear envelope ne by escrt iii", "Selective autophagy", "Selenoamino acid metabolism", "Sema3a pak dependent axon repulsion", "Sema3a plexin repulsion signaling by inhibiting integrin adhesion", "Sema4d in semaphorin signaling", "Sema4d induced cell migration and growth cone collapse", "Sema4d mediated inhibition of cell attachment and migration", "Semaphorin interactions", "Senescence associated secretory phenotype sasp", "Sensing of dna double strand breaks", "Sensory perception", "Sensory processing of sound", "Sensory processing of sound by outer hair cells of the cochlea", "Separation of sister chromatids", "Serine biosynthesis", "Serotonin neurotransmitter release cycle", "Shc mediated cascade fgfr1", "Shc mediated cascade fgfr3", "Shc mediated cascade fgfr4", "Shc related events triggered by igf1r", "Shc1 events in egfr signaling", "Shc1 events in erbb2 signaling", "Shc1 events in erbb4 signaling", "Sialic acid metabolism", "Signal amplification", "Signal attenuation", "Signal regulatory protein family interactions", "Signal transduction by l1", "Signaling by activin", "Signaling by alk", "Signaling by alk in cancer", "Signaling by bmp", "Signaling by braf and raf1 fusions", "Signaling by csf3 g csf", "Signaling by ctnnb1 phospho site mutants", "Signaling by cytosolic fgfr1 fusion mutants", "Signaling by egfr", "Signaling by egfr in cancer", "Signaling by erbb2", "Signaling by erbb2 ecd mutants", "Signaling by erbb2 in cancer", "Signaling by erbb4", "Signaling by erythropoietin", "Signaling by fgfr", "Signaling by fgfr in disease", "Signaling by fgfr1", "Signaling by fgfr1 in disease", "Signaling by fgfr2", "Signaling by fgfr2 iiia tm", "Signaling by fgfr2 in disease", "Signaling by fgfr3", "Signaling by fgfr3 fusions in cancer", "Signaling by fgfr4", "Signaling by fgfr4 in disease", "Signaling by flt3 fusion proteins", "Signaling by flt3 itd and tkd mutants", "Signaling by gpcr", "Signaling by hedgehog", "Signaling by hippo", "Signaling by insulin receptor", "Signaling by interleukins", "Signaling by kit in disease", "Signaling by leptin", "Signaling by mapk mutants", "Signaling by met", "Signaling by moderate kinase activity braf mutants", "Signaling by mras complex mutants", "Signaling by mst1", "Signaling by nodal", "Signaling by notch", "Signaling by notch1", "Signaling by notch1 pest domain mutants in cancer", "Signaling by notch2", "Signaling by notch3", "Signaling by notch4", "Signaling by ntrk2 trkb", "Signaling by ntrk3 trkc", "Signaling by ntrks", "Signaling by nuclear receptors", "Signaling by pdgf", "Signaling by pdgfr in disease", "Signaling by pdgfra transmembrane juxtamembrane and kinase domain mutants", "Signaling by ptk6", "Signaling by receptor tyrosine kinases", "Signaling by retinoic acid", "Signaling by rho gtpases miro gtpases and rhobtb3", "Signaling by robo receptors", "Signaling by scf kit", "Signaling by tgf beta receptor complex", "Signaling by tgfb family members", "Signaling by the b cell receptor bcr", "Signaling by type 1 insulin like growth factor 1 receptor igf1r", "Signaling by vegf", "Signaling by wnt", "Signaling by wnt in cancer", "Signalling to erks", "Signalling to ras", "Sirt1 negatively regulates rrna expression", "Slbp dependent processing of replication dependent histone pre mrnas", "Slc mediated transmembrane transport", "Slc transporter disorders", "Smad2 smad3 smad4 heterotrimer regulates transcription", "Small interfering rna sirna biogenesis", "Smooth muscle contraction", "Snrnp assembly", "Sodium calcium exchangers", "Sos mediated signalling", "Sphingolipid de novo biosynthesis", "Sphingolipid metabolism", "Spry regulation of fgf signaling", "Srp dependent cotranslational protein targeting to membrane", "Stabilization of p53", "Stat3 nuclear events downstream of alk signaling", "Stat5 activation", "Stat5 activation downstream of flt3 itd mutants", "Stimuli sensing channels", "Sting mediated induction of host immune responses", "Striated muscle contraction", "Sulfide oxidation to sulfate", "Sulfur amino acid metabolism", "Sumo is conjugated to e1 uba2 sae1", "Sumo is transferred from e1 to e2 ube2i ubc9", "Sumoylation", "Sumoylation of chromatin organization proteins", "Sumoylation of dna damage response and repair proteins", "Sumoylation of dna methylation proteins", "Sumoylation of dna replication proteins", "Sumoylation of rna binding proteins", "Sumoylation of sumoylation proteins", "Sumoylation of transcription cofactors", "Sumoylation of transcription factors", "Sumoylation of ubiquitinylation proteins", "Suppression of apoptosis", "Suppression of phagosomal maturation", "Surfactant metabolism", "Switching of origins to a post replicative state", "Synaptic adhesion like molecules", "Syndecan interactions", "Synthesis of 5 eicosatetraenoic acids", "Synthesis of active ubiquitin roles of e1 and e2 enzymes", "Synthesis of bile acids and bile salts", "Synthesis of bile acids and bile salts via 7alpha hydroxycholesterol", "Synthesis of diphthamide eef2", "Synthesis of dna", "Synthesis of dolichyl phosphate", "Synthesis of epoxy eet and dihydroxyeicosatrienoic acids dhet", "Synthesis of gdp mannose", "Synthesis of glycosylphosphatidylinositol gpi", "Synthesis of ip2 ip and ins in the cytosol", "Synthesis of ip3 and ip4 in the cytosol", "Synthesis of ketone bodies", "Synthesis of leukotrienes lt and eoxins ex", "Synthesis of lipoxins lx", "Synthesis of pa", "Synthesis of pc", "Synthesis of pe", "Synthesis of pg", "Synthesis of pi", "Synthesis of pips at the early endosome membrane", "Synthesis of pips at the er membrane", "Synthesis of pips at the golgi membrane", "Synthesis of pips at the late endosome membrane", "Synthesis of pips at the plasma membrane", "Synthesis of prostaglandins pg and thromboxanes tx", "Synthesis of pyrophosphates in the cytosol", "Synthesis of substrates in n glycan biosythesis", "Synthesis of udp n acetyl glucosamine", "Synthesis of very long chain fatty acyl coas", "Synthesis secretion and deacylation of ghrelin", "Synthesis secretion and inactivation of glucagon like peptide 1 glp 1", "Synthesis secretion and inactivation of glucose dependent insulinotropic polypeptide gip", "Tak1 activates nfkb by phosphorylation and activation of ikks complex", "Tbc rabgaps", "Tcf dependent signaling in response to wnt", "Tcr signaling", "Telomere c strand lagging strand synthesis", "Telomere c strand synthesis initiation", "Telomere extension by telomerase", "Telomere maintenance", "Termination of translesion dna synthesis", "Tetrahydrobiopterin bh4 synthesis recycling salvage and regulation", "Tfap2 ap 2 family regulates transcription of growth factors and their receptors", "Tfap2a acts as a transcriptional repressor during retinoic acid induced cell differentiation", "Tgf beta receptor signaling activates smads", "Tgf beta receptor signaling in emt epithelial to mesenchymal transition", "The activation of arylsulfatases", "The canonical retinoid cycle in rods twilight vision", "The citric acid tca cycle and respiratory electron transport", "The nlrp3 inflammasome", "The phototransduction cascade", "The role of gtse1 in g2 m progression after g2 checkpoint", "The role of nef in hiv 1 replication and disease pathogenesis", "Thrombin signalling through proteinase activated receptors pars", "Thromboxane signalling through tp receptor", "Ticam1 rip1 mediated ikk complex recruitment", "Ticam1 traf6 dependent induction of tak1 complex", "Tie2 signaling", "Tight junction interactions", "Tlr3 mediated ticam1 dependent programmed cell death", "Tnf receptor superfamily tnfsf members mediating non canonical nf kb pathway", "Tnf signaling", "Tnfr1 induced nfkappab signaling pathway", "Tnfr1 induced proapoptotic signaling", "Tnfr1 mediated ceramide production", "Tnfr2 non canonical nf kb pathway", "Toll like receptor 9 tlr9 cascade", "Toll like receptor cascades", "Toll like receptor tlr1 tlr2 cascade", "Toxicity of botulinum toxin type d botd", "Tp53 regulates metabolic genes", "Tp53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "Tp53 regulates transcription of caspase activators and caspases", "Tp53 regulates transcription of cell cycle genes", "Tp53 regulates transcription of cell death genes", "Tp53 regulates transcription of death receptors and ligands", "Tp53 regulates transcription of dna repair genes", "Tp53 regulates transcription of genes involved in cytochrome c release", "Tp53 regulates transcription of genes involved in g1 cell cycle arrest", "Tp53 regulates transcription of genes involved in g2 cell cycle arrest", "Tp53 regulates transcription of several additional cell death genes whose specific roles in p53 dependent apoptosis remain uncertain", "Traf3 dependent irf activation pathway", "Traf6 mediated induction of tak1 complex within tlr4 complex", "Traf6 mediated irf7 activation", "Traf6 mediated irf7 activation in tlr7 8 or 9 signaling", "Traf6 mediated nf kb activation", "Trafficking and processing of endosomal tlr", "Trafficking of ampa receptors", "Trafficking of glur2 containing ampa receptors", "Trafficking of myristoylated proteins to the cilium", "Trans golgi network vesicle budding", "Transcription coupled nucleotide excision repair tc ner", "Transcription of e2f targets under negative control by dream complex", "Transcription of e2f targets under negative control by p107 rbl1 and p130 rbl2 in complex with hdac1", "Transcription of the hiv genome", "Transcriptional activation of mitochondrial biogenesis", "Transcriptional activity of smad2 smad3 smad4 heterotrimer", "Transcriptional regulation by e2f6", "Transcriptional regulation by mecp2", "Transcriptional regulation by runx1", "Transcriptional regulation by runx2", "Transcriptional regulation by runx3", "Transcriptional regulation by small rnas", "Transcriptional regulation by the ap 2 tfap2 family of transcription factors", "Transcriptional regulation by tp53", "Transcriptional regulation by ventx", "Transcriptional regulation of granulopoiesis", "Transcriptional regulation of pluripotent stem cells", "Transcriptional regulation of white adipocyte differentiation", "Transferrin endocytosis and recycling", "Translation", "Translation of replicase and assembly of the replication transcription complex", "Translation of sars cov 1 structural proteins", "Translation of sars cov 2 structural proteins", "Translesion synthesis by polh", "Translesion synthesis by polk", "Translesion synthesis by y family dna polymerases bypasses lesions on dna template", "Translocation of slc2a4 glut4 to the plasma membrane", "Transmission across chemical synapses", "Transport and synthesis of paps", "Transport of bile salts and organic acids metal ions and amine compounds", "Transport of connexons to the plasma membrane", "Transport of fatty acids", "Transport of inorganic cations anions and amino acids oligopeptides", "Transport of mature mrnas derived from intronless transcripts", "Transport of mature transcript to cytoplasm", "Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane", "Transport of nucleotide sugars", "Transport of small molecules", "Transport of the slbp dependant mature mrna", "Transport of vitamins nucleosides and related molecules", "Transport to the golgi and subsequent modification", "Trif mediated programmed cell death", "Triglyceride biosynthesis", "Triglyceride catabolism", "Triglyceride metabolism", "Tristetraprolin ttp zfp36 binds and destabilizes mrna", "Trna aminoacylation", "Trna modification in the mitochondrion", "Trna modification in the nucleus and cytosol", "Trna processing", "Trna processing in the mitochondrion", "Trna processing in the nucleus", "Trp channels", "Tryptophan catabolism", "Type i hemidesmosome assembly", "Tyrosine catabolism", "Tysnd1 cleaves peroxisomal proteins", "Ub specific processing proteases", "Ubiquinol biosynthesis", "Uch proteinases", "Unblocking of nmda receptors glutamate binding and activation", "Unfolded protein response upr", "Unwinding of dna", "Uptake and actions of bacterial toxins", "Uptake and function of anthrax toxins", "Uptake and function of diphtheria toxin", "Urea cycle", "Vasopressin regulates renal water homeostasis via aquaporins", "Vegfr2 mediated cell proliferation", "Vegfr2 mediated vascular permeability", "Vesicle mediated transport", "Viral messenger rna synthesis", "Visual phototransduction", "Vitamin b1 thiamin metabolism", "Vitamin b2 riboflavin metabolism", "Vitamin b5 pantothenate metabolism", "Vitamin c ascorbate metabolism", "Vitamin d calciferol metabolism", "Vldl assembly", "Vldlr internalisation and degradation", "Vxpx cargo targeting to cilium", "Wax and plasmalogen biosynthesis", "Wnt ligand biogenesis and trafficking", "Wnt mediated activation of dvl", "Wnt5a dependent internalization of fzd2 fzd5 and ror2", "Wnt5a dependent internalization of fzd4", "Zbp1 dai mediated induction of type i ifns", "Zinc influx into cells by the slc39 gene family", "Zinc transporters"], "available_proteins": ["AAAS", "AARS", "AARS2", "AASDHPPT", "AASS", "AATF", "ABCB1", "ABCB10", "ABCB6", "ABCB7", "ABCB8", "ABCC4", "ABCD3", "ABCE1", "ABCF1", "ABHD10", "ABHD12", "ABHD14B", "ABHD6", "ABRAXAS2", "ACAA1", "ACAA2", "ACACA", "ACACB", "ACAD11", "ACAD9", "ACADM", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACBD5", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT8", "ACOT9", "ACOX1", "ACOX3", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACSL6", "ACTL6A", "ACTN1", "ACTN4", "ACTR1A", "ACTR1B", "ACTR2", "ACTR3", "ACTR8", "ADA", "ADAR", "ADD1", "ADD3", "ADH5", "ADI1", "ADK", "ADPGK", "ADRM1", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGK", "AGL", "AGPAT1", "AGPAT5", "AGPS", "AHCTF1", "AHCY", "AHCYL1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AK3", "AK4", "AK6", "AKAP1", "AKAP10", "AKAP9", "AKR1A1", "AKR1B1", "AKR7A2", "AKT2", "ALDH18A1", "ALDH1A2", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALG1", "ALG11", "ALG5", "ALKBH5", "ALYREF", "AMOT", "ANAPC1", "ANAPC16", "ANAPC2", "ANAPC4", "ANAPC5", "ANAPC7", "ANK3", "ANKFY1", "ANKLE2", "ANLN", "ANO10", "ANO6", "ANP32A", "ANXA1", "ANXA2", "ANXA6", "AP1B1", "AP1G1", "AP1M1", "AP1S1", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3M1", "APEH", "APEX1", "APOO", "APOOL", "APP", "APPL1", "APRT", "AQR", "ARCN1", "ARF4", "ARF6", "ARFGAP1", "ARFIP2", "ARG2", "ARHGAP17", "ARHGDIA", "ARHGEF2", "ARID1A", "ARID2", "ARIH2", "ARL1", "ARL2", "ARL3", "ARL6IP5", "ARL8A", "ARMCX3", "ARPC1A", "ARPC2", "ARPC3", "ARPC4", "ASAH1", "ASB6", "ASCC2", "ASCC3", "ASH2L", "ASNA1", "ASNS", "ASPH", "ASPSCR1", "ATAD1", "ATAD2", "ATAD3B", "ATG3", "ATG9A", "ATIC", "ATP13A1", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP2B4", "ATP2C1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6AP1", "ATP6AP2", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1D", "ATP6V1E1", "ATP6V1H", "ATP7A", "ATP7B", "ATRIP", "AURKA", "B3GALT6", "B4GAT1", "BABAM1", "BABAM2", "BAG2", "BAG3", "BAG4", "BAG5", "BAG6", "BAIAP2", "BANF1", "BARD1", "BASP1", "BAZ1B", "BAZ2A", "BCAP31", "BCAS2", "BCKDK", "BCR", "BCS1L", "BICD2", "BIRC6", "BLM", "BLMH", "BLVRA", "BMS1", "BNIP1", "BOLA2*", "BOP1", "BPNT1", "BRAP", "BRCA1", "BRD1", "BRD2", "BRD4", "BSG", "BUB1B", "BUB3", "BUD23", "BUD31", "BYSL", "C19orf70", "C1QBP", "C1orf35", "C2CD5", "C2orf49", "CAB39", "CAD", "CALD1", "CALR", "CALU", "CAMK2G", "CAND1", "CANT1", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPNS1", "CAPZA1", "CAPZB", "CARS", "CASK", "CAST", "CBR1", "CBX1", "CBX2", "CBX3", "CBX5", "CBX8", "CCAR1", "CCAR2", "CCDC22", "CCDC59", "CCNB1", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2AP", "CD2BP2", "CD3EAP", "CD47", "CDC16", "CDC23", "CDC27", "CDC37", "CDC42", "CDC5L", "CDC73", "CDCA5", "CDCA8", "CDH2", "CDIPT", "CDK1", "CDK12", "CDK2", "CDK4", "CDK5", "CDK6", "CDK9", "CDKAL1", "CDKN2A", "CDS2", "CENPI", "CENPP", "CEP72", "CERS2", "CERS5", "CETN2", "CFL1", "CHAC2", "CHAF1B", "CHAMP1", "CHCHD3", "CHD1", "CHD1L", "CHD4", "CHD8", "CHDH", "CHERP", "CHID1", "CHKA", "CHMP2B", "CHMP3", "CHMP4B", "CHMP5", "CHMP7", "CHORDC1", "CHST14", "CHTF18", "CHTOP", "CIAPIN1", "CIT", "CKAP4", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLASP2", "CLCN3", "CLCN7", "CLINT1", "CLNS1A", "CLSPN", "CLTA", "CLTB", "CLTC", "CMAS", "CMPK1", "CNDP2", "CNN2", "CNOT1", "CNOT4", "CNOT9", "COG2", "COG3", "COG4", "COG5", "COG6", "COG7", "COL4A3BP", "COLEC12", "COLGALT1", "COMMD8", "COMT", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS8", "COPZ1", "COQ9", "COTL1", "COX15", "COX18", "COX2", "COX4I1", "COX5A", "COX5B", "COX6C", "COX7A2L", "CPD", "CPNE1", "CPNE3", "CPNE8", "CPOX", "CPSF1", "CPSF2", "CPSF3", "CPSF6", "CPSF7", "CPT1A", "CPT2", "CRK", "CRKL", "CRNKL1", "CRTAP", "CS", "CSGALNACT2", "CSK", "CSNK1A1", "CSNK2A1", "CSNK2A2", "CSNK2B", "CSTB", "CSTF1", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTPS2", "CTR9", "CTSA", "CTSC", "CTTN", "CTU2", "CUL1", "CUL2", "CUL3", "CUL4A", "CUL4B", "CUL5", "CWC15", "CWC22", "CXADR", "CYB5B", "CYB5R1", "CYB5R3", "CYC1", "CYFIP1", "CYFIP2", "CYP51A1", "DAGLB", "DAP3", "DARS", "DARS2", "DBN1", "DBNL", "DBT", "DCAF1", "DCAF13", "DCAF7", "DCAF8", "DCD", "DCP1B", "DCPS", "DCTD", "DCTN1", "DCTN2", "DCTN3", "DCTN4", "DCTPP1", "DCUN1D1", "DCUN1D5", "DCXR", "DDB1", "DDOST", "DDRGK1", "DDX1", "DDX17", "DDX20", "DDX21", "DDX23", "DDX39A", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX52", "DDX56", "DDX6", "DEK", "DENND6A", "DERL1", "DERL2", "DFFA", "DHCR24", "DHCR7", "DHFR", "DHPS", "DHRS7B", "DHTKD1", "DHX15", "DHX16", "DHX36", "DHX37", "DHX38", "DHX9", "DIAPH1", "DIAPH2", "DIAPH3", "DICER1", "DIDO1", "DIEXF", "DIMT1", "DIS3", "DKC1", "DLAT", "DLD", "DLG1", "DLGAP5", "DLST", "DMAP1", "DNA2", "DNAJA1", "DNAJA2", "DNAJB1", "DNAJC11", "DNAJC13", "DNAJC2", "DNAJC3", "DNAJC7", "DNAJC8", "DNM1L", "DNM2", "DNMT1", "DNPH1", "DOCK7", "DOHH", "DOLPP1", "DPH2", "DPH5", "DPM1", "DPY30", "DPYSL2", "DPYSL3", "DPYSL5", "DSC3", "DSG2", "DSP", "DST", "DTX3L", "DTYMK", "DUS2", "DUSP3", "DUSP9", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNC2H1", "DYNLL1", "DYNLL2", "EARS2", "EBNA1BP2", "EBP", "ECE1", "ECH1", "ECHS1", "ECI1", "ECI2", "ECSIT", "EDC3", "EDC4", "EEA1", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EFTUD2", "EHD1", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E", "EIF4E2", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAC2", "ELAVL1", "ELL", "ELMO2", "ELOA", "ELOB", "ELP1", "ELP2", "ELP3", "ELP4", "EMD", "EMG1", "EML4", "ENAH", "ENDOD1", "ENO1", "ENO2", "ENY2", "EP400", "EPB41", "EPB41L2", "EPB41L3", "EPB41L5", "EPHA7", "EPHX1", "EPHX2", "EPN1", "EPRS", "EPS15L1", "ERAL1", "ERAP1", "ERAP2", "ERBIN", "ERCC2", "ERCC3", "ERCC6L", "ERLIN1", "ERLIN2", "ERO1A", "ERO1B", "ESD", "ESYT1", "ESYT2", "ETF1", "ETFA", "ETFB", "ETFDH", "EXO1", "EXOC2", "EXOC3", "EXOC5", "EXOC6", "EXOC7", "EXOC8", "EXOSC1", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC8", "EXOSC9", "EYA4", "EZR", "F11R", "FADS2", "FAF2", "FAH", "FAHD1", "FAM114A2", "FAM49B", "FAM98B", "FANCD2", "FANCI", "FAR1", "FARP1", "FARP2", "FARSA", "FARSB", "FASN", "FAU", "FBL", "FDFT1", "FDPS", "FDXR", "FECH", "FEN1", "FERMT2", "FGFR1OP", "FH", "FIP1L1", "FIS1", "FKBP14", "FKBP4", "FKBP5", "FKBP8", "FLAD1", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FNTA", "FNTB", "FOXK1", "FSCN1", "FTO", "FTSJ3", "FUCA1", "FUCA2", "FUS", "FXR1", "G6PD", "GAA", "GABARAPL2", "GADD45GIP1", "GAK", "GALK1", "GALNS", "GALNT1", "GALNT2", "GALNT4", "GALNT7", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GATAD2B", "GBA", "GBF1", "GCAT", "GCDH", "GCFC2", "GCLC", "GCN1", "GDAP1", "GDI1", "GDI2", "GDPD1", "GEMIN4", "GEMIN5", "GEMIN8", "GET4", "GFM1", "GFPT1", "GGA1", "GGCT", "GGCX", "GGH", "GGT7", "GHDC", "GINS2", "GINS3", "GINS4", "GLA", "GLB1", "GLCE", "GLDC", "GLE1", "GLG1", "GLMN", "GLO1", "GLRX3", "GLRX5", "GLS", "GLTP", "GLUD1", "GM2A", "GMPS", "GNA13", "GNAI1", "GNAI2", "GNAI3", "GNAQ", "GNE", "GNG12", "GNG5", "GNL3", "GNPAT", "GNPDA1", "GNPNAT1", "GNS", "GOLGA2", "GOLGA3", "GOLGA5", "GOLGB1", "GOLIM4", "GORASP2", "GOSR1", "GOT1", "GOT2", "GPAA1", "GPAM", "GPAT4", "GPD1L", "GPD2", "GPHN", "GPI", "GPKOW", "GPS1", "GPT2", "GPX8", "GRB2", "GRHPR", "GRPEL1", "GRSF1", "GSK3B", "GSPT1", "GSR", "GSS", "GSTK1", "GSTM3", "GSTO1", "GSTZ1", "GTF2E1", "GTF2E2", "GTF2F1", "GTF2H1", "GTF2H4", "GTF3C1", "GTF3C2", "GTF3C3", "GTF3C4", "GTF3C5", "GTPBP3", "GYG1", "GYS1", "H1F0", "H4C1*", "HACD3", "HACL1", "HADH", "HADHA", "HADHB", "HARS2", "HAT1", "HAUS1", "HAUS3", "HAUS4", "HAUS5", "HAUS6", "HBS1L", "HCFC1", "HDAC1", "HDAC2", "HDGF", "HDLBP", "HEATR1", "HEBP1", "HECTD1", "HECTD3", "HEXA", "HEXB", "HGS", "HIBADH", "HIBCH", "HINT2", "HIRA", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLTF", "HM13", "HMBS", "HMGA1", "HMGB1", "HMGB2", "HMGCL", "HMGCR", "HMGCS1", "HMMR", "HMOX1", "HMOX2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPK", "HNRNPL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HPRT1", "HS2ST1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSD17B7", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA13", "HSPA14", "HSPA1B", "HSPA2", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPD1", "HSPE1", "HSPH1", "HTT", "HUWE1", "HYOU1", "IARS", "IARS2", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDH3G", "IDI1", "IFIT5", "IFT27", "IFT81", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IKBKB", "ILF2", "ILK", "IMMT", "IMP3", "IMP4", "IMPAD1", "IMPDH1", "IMPDH2", "INPP4A", "INPPL1", "INTS1", "INTS11", "INTS14", "INTS2", "INTS3", "INTS4", "INTS7", "INTS8", "INTS9", "IPO5", "IPO8", "IPO9", "IQCB1", "IQGAP1", "IQGAP3", "IRS4", "ISG20L2", "IST1", "ISY1", "ISYNA1", "ITCH", "ITGB1", "ITM2C", "ITPA", "ITPK1", "ITSN2", "IVD", "IWS1", "JMJD6", "JUP", "KARS", "KAT7", "KDELR1", "KDM1A", "KDM1B", "KDM2A", "KDM3B", "KDM5A", "KDSR", "KHDRBS1", "KHDRBS3", "KHSRP", "KIAA0391", "KIDINS220", "KIF11", "KIF14", "KIF18A", "KIF18B", "KIF1A", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF3A", "KIF4A", "KIF5B", "KIN", "KLC1", "KLC4", "KLHL11", "KMT2A", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNA6", "KPNB1", "KRR1", "KTN1", "KYAT3", "L2HGDH", "LAMB1", "LAMC1", "LAMP1", "LAMP2", "LAMTOR1", "LARS", "LARS2", "LAS1L", "LBR", "LCLAT1", "LDHA", "LDHB", "LDLR", "LEMD3", "LETM1", "LGALS3", "LGALS3BP", "LGMN", "LIG1", "LIG3", "LIN9", "LIPA", "LLGL1", "LMAN2", "LMAN2L", "LMF2", "LMNA", "LMNB1", "LNPEP", "LPCAT1", "LPGAT1", "LRP1", "LRPPRC", "LRRC1", "LRRC8C", "LRSAM1", "LSM2", "LSM4", "LSM6", "LSM7", "LSS", "LTA4H", "LTN1", "LTV1", "LYN", "LYPLA1", "LZTFL1", "M6PR", "MAGED2", "MAGT1", "MAIP1", "MALT1", "MAN2A1", "MAN2B1", "MANF", "MAPK1", "MAPK14", "MAPRE1", "MARC1", "MARS", "MARS2", "MAT2A", "MAT2B", "MAU2", "MAVS", "MBD3", "MBOAT7", "MCAM", "MCCC1", "MCCC2", "MCL1", "MCM10", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCU", "MCUB", "MDC1", "MDH1", "MDH2", "ME1", "ME2", "MECP2", "MED14", "MED17", "MED22", "MED23", "MED24", "MED4", "METAP1", "METAP2", "METTL3", "MFN1", "MFN2", "MGST2", "MGST3", "MIA2", "MIA3", "MICU1", "MIF", "MIGA1", "MINPP1", "MIPEP", "MLEC", "MMAB", "MMS19", "MOCOS", "MOGS", "MORC2", "MORF4L1", "MORF4L2", "MOSPD2", "MOV10", "MPC2", "MPG", "MPHOSPH10", "MPHOSPH6", "MPI", "MPP1", "MPP2", "MPP7", "MPRIP", "MPST", "MPV17", "MRC2", "MRE11", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL14", "MRPL15", "MRPL17", "MRPL19", "MRPL2", "MRPL20", "MRPL21", "MRPL22", "MRPL24", "MRPL28", "MRPL3", "MRPL37", "MRPL38", "MRPL39", "MRPL40", "MRPL41", "MRPL43", "MRPL44", "MRPL45", "MRPL46", "MRPL47", "MRPL48", "MRPL49", "MRPL50", "MRPL53", "MRPL58", "MRPL9", "MRPS11", "MRPS16", "MRPS18A", "MRPS22", "MRPS23", "MRPS25", "MRPS27", "MRPS28", "MRPS30", "MRPS31", "MRPS33", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRPS9", "MRRF", "MSH2", "MSH3", "MSH6", "MSI1", "MSI2", "MSMO1", "MSN", "MTA1", "MTA2", "MTAP", "MTCH1", "MTHFD1", "MTHFD1L", "MTHFD2", "MTHFS", "MTMR14", "MTMR2", "MTMR6", "MTO1", "MTOR", "MTR", "MTX1", "MTX2", "MUL1", "MUT", "MVD", "MYBBP1A", "MYDGF", "MYH10", "MYH14", "MYH9", "MYL6", "MYO18A", "MYO1C", "MYO6", "NAA35", "NAE1", "NAGLU", "NAMPT", "NANS", "NAPA", "NAPG", "NARS", "NAT10", "NAXE", "NBAS", "NBN", "NCAPD2", "NCAPD3", "NCAPG", "NCAPG2", "NCAPH", "NCBP1", "NCEH1", "NCKAP1", "NCKIPSD", "NCL", "NCOR1", "NCSTN", "ND1", "NDC1", "NDC80", "NDUFA10", "NDUFA11", "NDUFA13", "NDUFA4", "NDUFA5", "NDUFA7", "NDUFA8", "NDUFA9", "NDUFAF2", "NDUFAF3", "NDUFAF4", "NDUFAF7", "NDUFB10", "NDUFB3", "NDUFB4", "NDUFB5", "NDUFB6", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS6", "NDUFS7", "NDUFS8", "NDUFV1", "NDUFV2", "NECAP2", "NEDD1", "NEDD4L", "NEFL", "NEK9", "NELFA", "NELFB", "NELFCD", "NELFE", "NF1", "NFS1", "NHLRC2", "NHP2", "NIP7", "NIPBL", "NIPSNAP2", "NISCH", "NIT2", "NLN", "NLRX1", "NME1", "NME2", "NMT1", "NNT", "NOB1", "NOC2L", "NOC4L", "NOL11", "NOL6", "NOL9", "NOP14", "NOP2", "NOP56", "NOP58", "NOSIP", "NOTCH2", "NPC1", "NPC2", "NPEPPS", "NPLOC4", "NPM1", "NRBP1", "NRP1", "NSD1", "NSD2", "NSD3", "NSDHL", "NSF", "NSMCE2", "NSUN2", "NT5C2", "NT5C3A", "NT5C3B", "NTHL1", "NUB1", "NUBP2", "NUBPL", "NUCB1", "NUDC", "NUDT1", "NUDT21", "NUDT5", "NUF2", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP160", "NUP188", "NUP205", "NUP210", "NUP214", "NUP35", "NUP37", "NUP43", "NUP50", "NUP54", "NUP58", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NUPL2", "NXF1", "OAT", "OCLN", "OCRL", "OGDH", "OGT", "OLA1", "OPA1", "ORC2", "ORC3", "ORC5", "OSBP", "OSBPL11", "OSBPL1A", "OSBPL6", "OSBPL8", "OSBPL9", "OSGEP", "OSTF1", "OTUB1", "OXA1L", "P3H1", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPC1", "PABPN1", "PACSIN2", "PAF1", "PAFAH1B1", "PAFAH1B2", "PAFAH1B3", "PAICS", "PAK2", "PANK4", "PAPOLA", "PAPSS1", "PARD3", "PARG", "PARK7", "PARN", "PARP1", "PARP2", "PATL1", "PBRM1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCM1", "PCMT1", "PCNA", "PDAP1", "PDCD11", "PDCD6", "PDCD6IP", "PDE12", "PDHA1", "PDHB", "PDHX", "PDIA3", "PDIA6", "PDK1", "PDK3", "PDLIM5", "PDP1", "PDS5A", "PDS5B", "PDSS2", "PEBP1", "PECR", "PELP1", "PES1", "PEX11B", "PEX14", "PEX19", "PEX3", "PFAS", "PFDN2", "PFDN4", "PFDN5", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGM3", "PGP", "PGRMC1", "PGRMC2", "PHB", "PHB2", "PHF2", "PHF5A", "PHGDH", "PHIP", "PHKA1", "PHKB", "PI4K2A", "PI4KA", "PI4KB", "PICALM", "PIGG", "PIGK", "PIGS", "PIGT", "PIGU", "PIK3C2A", "PIK3R2", "PIK3R4", "PIN1", "PIP4K2C", "PIR", "PISD", "PITPNA", "PITPNB", "PITRM1", "PKM", "PKMYT1", "PKN1", "PKN2", "PLA2G15", "PLCG1", "PLD3", "PLD6", "PLEC", "PLEKHA5", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLRG1", "PMPCA", "PMPCB", "PMVK", "PNKP", "PNO1", "PNP", "PNPLA6", "PNPLA8", "POFUT1", "POLA1", "POLA2", "POLD1", "POLD2", "POLDIP2", "POLDIP3", "POLE", "POLE2", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2A", "POLR2B", "POLR2C", "POLR2D", "POLR2E", "POLR2G", "POLR2L", "POLR3A", "POLR3B", "POLR3C", "POLRMT", "PON2", "POP1", "POP4", "POR", "PPA1", "PPA2", "PPAT", "PPCDC", "PPFIA1", "PPIB", "PPID", "PPIE", "PPIH", "PPIL4", "PPME1", "PPOX", "PPP1CA", "PPP1CB", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP2R5E", "PPP3CA", "PPP5C", "PPP6C", "PPP6R3", "PPT1", "PPWD1", "PQBP1", "PRC1", "PRCC", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PRIM1", "PRIM2", "PRKAA1", "PRKAA2", "PRKACA", "PRKAG1", "PRKAR1A", "PRKAR2A", "PRKCB", "PRKCSH", "PRKDC", "PRMT1", "PRMT3", "PRMT5", "PRPF19", "PRPF3", "PRPF31", "PRPF4", "PRPF40A", "PRPF6", "PRPF8", "PRPS2", "PSAP", "PSAT1", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD6", "PSMD7", "PSMD8", "PSME1", "PSME2", "PSME3", "PSME4", "PTBP1", "PTCD3", "PTDSS1", "PTDSS2", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK2", "PTPN1", "PTPN11", "PTPN23", "PTPRF", "PTRH2", "PUF60", "PUS1", "PUS7", "PWP2", "PXMP2", "PXN", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QDPR", "QKI", "QTRT2", "RAB10", "RAB12", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB1B", "RAB23", "RAB24", "RAB2A", "RAB34", "RAB35", "RAB3B", "RAB3GAP1", "RAB3GAP2", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RAB8A", "RAB9A", "RABEPK", "RABGAP1", "RABGGTA", "RAC1", "RACGAP1", "RACK1", "RAD18", "RAD21", "RAD23A", "RAD23B", "RAD50", "RAE1", "RALA", "RAN", "RANBP1", "RANBP2", "RANBP9", "RANGAP1", "RAP1GDS1", "RAPGEF2", "RARS", "RARS2", "RBBP4", "RBBP5", "RBBP6", "RBBP7", "RBM14", "RBM17", "RBM22", "RBM28", "RBM4", "RBM5", "RBM8A", "RBMX", "RBPJ", "RCC1", "RCC2", "RCL1", "RCN1", "RDH11", "RDH13", "RDH14", "RDX", "RETSAT", "REXO2", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RFT1", "RHEB", "RHOG", "RHOT1", "RHOT2", "RIDA", "RIF1", "RINT1", "RIPK1", "RNASET2", "RNF2", "RNF20", "RNF40", "RNMT", "RNPS1", "ROBO1", "ROCK1", "ROCK2", "RP2", "RPA1", "RPA2", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPN1", "RPN2", "RPP30", "RPP38", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS26", "RPS28", "RPS29", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RPTOR", "RRAS2", "RRBP1", "RRM1", "RRM2", "RRP1", "RRP36", "RRP8", "RRP9", "RSF1", "RSU1", "RTCB", "RTN3", "RTN4", "RTRAF", "RUFY1", "RUVBL1", "RUVBL2", "S100A11", "SACM1L", "SAE1", "SAFB", "SAMHD1", "SAMM50", "SAP130", "SAP18", "SAP30BP", "SAR1B", "SARM1", "SARNP", "SARS", "SARS2", "SART1", "SCAMP1", "SCARB1", "SCARB2", "SCCPDH", "SCD", "SCFD1", "SCO1", "SCO2", "SCP2", "SCRIB", "SDHA", "SDHB", "SDHC", "SEC11A", "SEC16A", "SEC22B", "SEC23A", "SEC23IP", "SEC24A", "SEC24B", "SEC24C", "SEC31A", "SEC61A1", "SEC61B", "SEH1L", "SEL1L", "SENP3", "SEPT2", "SEPT7", "SERPINB6", "SERPINH1", "SET", "SETD1A", "SETD2", "SETD3", "SETDB1", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SGF29", "SGPL1", "SGTA", "SH3GL1", "SHMT1", "SHMT2", "SHTN1", "SIGMAR1", "SIN3A", "SKA1", "SKIV2L", "SKIV2L2", "SKP1", "SKP2", "SLC12A2", "SLC16A1", "SLC19A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A16", "SLC25A17", "SLC25A19", "SLC25A20", "SLC25A21", "SLC25A26", "SLC25A32", "SLC25A4", "SLC25A44", "SLC25A5", "SLC25A6", "SLC27A4", "SLC33A1", "SLC35B2", "SLC39A14", "SLC3A2", "SLC4A2", "SLC5A6", "SLC7A1", "SLIT2", "SLK", "SMARCA4", "SMARCA5", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC5", "SMC6", "SMG1", "SMG5", "SMN1*", "SMNDC1", "SMPD4", "SMS", "SND1", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPC", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNU13", "SNW1", "SNX2", "SNX3", "SNX5", "SNX9", "SOAT1", "SOD2", "SORD", "SORT1", "SPAG9", "SPC25", "SPCS2", "SPCS3", "SPDL1", "SPEN", "SPPL2A", "SPR", "SPTAN1", "SPTBN1", "SPTLC1", "SPTLC2", "SQLE", "SRC", "SRI", "SRM", "SRP14", "SRP54", "SRP68", "SRP72", "SRP9", "SRPK1", "SRPK2", "SRPRA", "SRPRB", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF3", "SRSF4", "SRSF5", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSR1", "SSR4", "SSRP1", "STAG1", "STAG2", "STAM", "STAM2", "STAT1", "STAT3", "STIP1", "STK26", "STK3", "STK4", "STMN1", "STOM", "STOML2", "STRAP", "STRN", "STT3A", "STUB1", "STX10", "STX16", "STX18", "STX4", "STXBP2", "STXBP3", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGT1", "SUN1", "SUN2", "SUPT16H", "SUPT3H", "SUPT5H", "SUPT6H", "SUZ12", "SV2A", "SYMPK", "SYNE1", "SYNE2", "SYS1", "TAB1", "TACC3", "TAF15", "TAF6", "TAGLN2", "TALDO1", "TAP1", "TAP2", "TARS", "TARS2", "TBC1D13", "TBC1D15", "TBC1D4", "TBCA", "TBCB", "TBCD", "TBCE", "TBL1XR1", "TBL3", "TCEA1", "TCP1", "TDRKH", "TECR", "TERF2IP", "TEX10", "TEX264", "TFAM", "TFB1M", "TFG", "TFIP11", "TFRC", "TGOLN2", "THADA", "THOC1", "THOC2", "THOC3", "THOC5", "THOC6", "THOP1", "THRAP3", "THUMPD1", "TIA1", "TIAL1", "TIGAR", "TIMM10B", "TIMM17B", "TIMM23", "TIMM44", "TIMM50", "TIMM8B", "TJP1", "TJP2", "TK1", "TKT", "TLE3", "TLN1", "TMED10", "TMED2", "TMED7", "TMED9", "TMEM11", "TMEM115", "TMEM87A", "TMLHE", "TMOD3", "TMPO", "TMPO", "TMX3", 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6.432038834951456 0.0687547082162972 0.1728701573933007 1.3368036576958324 0.5554170290527195 1.9109030412897592 0.2451148181788838 1.2286404123364386e-05 0.0424464003246627 0.0832836732680532 0.1973959389561772 2.8311070051942505e-05 +Familial partial lipodystrophy fpld 5 8 2.362821097494096 0.0181364224266118 2.7354368932038833 7.351941747572815 1.0487704575374006 0.2220749325398317 1.64741826657551 0.7567951823729889 1.2080189526980365 0.2461617416466816 0.0013201811074834 0.0963063052639835 0.0010099703116007 0.0014320459890063 0.0003689915939861 +Amyotrophic lateral sclerosis als 4 9 2.3297548409997746 0.0198191122011921 2.7305825242718447 9.96116504854369 0.4205357655297272 0.5708808425163486 1.655451908056762 1.5928988662189754 0.7372675469681915 0.2961491189852112 0.1317448684815962 1.0 1.0 1.0 0.0157766780310383 +Cholesterol metabolism with bloch and kandutschrussell pathways 15 25 2.285848878449151 0.0222631010434835 7.092233009708738 23.070388349514563 1.3045876527781233 0.2885598195159411 3.1892169450204397 2.132138915277104 1.1515799969949023 0.3088028425519339 9.934794437377244e-05 0.1635258499471353 0.048990890514732 2.159661966497117e-06 5.121649611699266e-05 +Oxidative phosphorylation 13 31 2.26626932525431 0.0234348983391681 10.094660194174756 30.308252427184467 0.4493106572238387 0.4094278581483465 4.631390429635194 3.3340884045985604 1.35936739882113 0.3321380007425058 6.225931093250928e-06 0.0257535715284909 0.0001345504873834 0.0081044088621321 7.915219655591412e-07 +Acquired partial lipodystrophy barraquersimons syndrome 4 5 2.2351888279952 0.0254049546310213 1.7402912621359223 4.497572815533981 0.9065154927122356 0.2548673055649036 1.4953091418597944 0.5048251951988992 1.235575791841686 0.2574096858611674 8.749910462019326e-05 0.0331691185540615 0.0018609890552042 0.0004519701832281 5.11944457815466e-06 +Cholesterol biosynthesis with skeletal dysplasias 4 6 2.231041944077412 0.025678350771745 2.703883495145631 6.024271844660194 1.6250539245333766 0.1427602110791373 1.3052115351448448 0.7101163612316155 0.9675759117714408 0.205892393525391 8.749910462019326e-05 1.0 0.0653907127050202 1.093284607508717e-05 5.11944457815466e-06 +Kennedy pathway from sphingolipids 4 5 2.2220239528951624 0.0262816868908846 1.8349514563106797 4.538834951456311 1.005685357170638 0.2842758763214292 1.1414272055653287 1.0616650240280194 1.1079123437614409 0.2814205551839854 0.0019907060593634 1.0 0.1265462710440741 0.0041470760753771 0.0003671727016274 +Influence of laminopathies on wnt signaling 4 11 2.2218453802351115 0.0262937567021563 2.929611650485437 10.199029126213592 1.172665957836072 0.274405530989148 1.5096443497648335 1.3031697834850824 0.8784257604250459 0.2713478851839423 0.0068337419321114 0.134742527043449 0.0028960612595367 0.0055331858379351 0.0137665493817408 +Mitochondrial complex iii assembly 4 10 2.2127892824503785 0.0269121765269464 3.3106796116504853 9.259708737864075 1.0287385637679851 0.2644162586394033 1.7668969355473032 1.3138647920792297 1.192785152283574 0.2813694304742245 0.021417379304658 0.0022827689145391 0.0088504827764808 0.0495157384890535 0.0334620993119388 +Oxidation by cytochrome p450 3 6 2.200574619545824 0.0277661519987213 2.3179611650485437 5.422330097087379 1.262256455948566 0.1900711291682963 1.161003800051733 0.6764315332620536 1.214909583878196 0.2447393771863318 0.001468971718364 0.0017062060788896 0.0002296483500821 0.0033170374819039 0.0027630263410089 +Mitochondrial complex i assembly model oxphos system 10 26 2.134824568704522 0.032775342639113 8.808252427184467 26.563106796116504 0.7827212026364002 0.3851038550171766 4.050605834390814 3.9632288075289823 1.2210776523685654 0.3331428769936953 0.0061225090155254 0.0276250495673642 0.0149914480702132 0.0408612650970917 0.001050513287845 +Intracellular trafficking proteins involved in cmt neuropathy 4 9 2.0955465872410186 0.0361224316360597 2.5825242718446604 9.4126213592233 0.5651067696606721 0.3956590939588119 1.7010805922853014 1.920668351091252 1.0307289556591432 0.2847016918534578 0.0112321972683931 1.0 1.0 0.4160065505344545 0.0034992238505004 +Glycerophospholipid biosynthetic pathway 6 8 2.06215232873788 0.0391932356571473 3.058252427184466 7.264563106796117 0.3097224827204536 0.3481868464538606 1.7226376406937374 1.7873358580072474 1.274716840477959 0.2785476931941232 0.0881871975325996 1.0 1.0 0.4704807306772423 0.0351238878380088 +Glycerolipids and glycerophospholipids 3 6 1.9893842597522624 0.0466588056630667 1.902439024390244 5.282926829268293 0.2570184705733445 0.3919307408190254 1.3234264111744822 1.6756363827898255 1.2288051208295987 0.2955621473168567 0.0461853959222372 1.0 1.0 0.0828772873031817 0.0143001062154138 +Statin inhibition of cholesterol production 3 7 1.980364351082204 0.0476626026709114 2.0315533980582523 5.029126213592233 1.044092701346018 0.2144191485801186 1.2890406286437517 1.2084356467042294 1.2621579412510306 0.2395890160394713 0.0019907060593634 1.0 1.0 0.0002735626391213 0.003721367796782 diff --git a/msigdb_wp/metrics.json b/msigdb_wp/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..4e2236b73085703b139687b275c259e0388e2aa7 --- /dev/null +++ b/msigdb_wp/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3221, + "annotations_size": 598, + "title": "Average number of proteins per term", + "value": 10.52675585284281 +} \ No newline at end of file diff --git a/msigdb_wp/paths.json b/msigdb_wp/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..ddca85f7698cafa48db0f84be3b83e372b008b29 --- /dev/null +++ b/msigdb_wp/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/msigdb_wp/fragment/C201/C201_val_log2fc"} \ No newline at end of file diff --git a/msigdb_wp/result.tsv b/msigdb_wp/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..bcd49b554b97a69f5db589b017c481f044422f38 --- /dev/null +++ b/msigdb_wp/result.tsv @@ -0,0 +1,127 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Electron transport chain oxphos system in mitochondria 0.6430137901730284 3.561697517944699 0.0003684647528245 0.1977881278601791 0.1232298326774106 52 O14949,P06576,P20674,P56385,P05141,Q7KZN9,Q9UDW1,P22695,P03886,O43676,O95139,O14548,P14406,P24539,P00403,P13073,O95168,O95299,O96000,O75964,Q9Y6M9,P21912,P12236,O75880,P51970,P12235 26 +Sphingolipid pathway 0.8279652746816186 2.994765260828866 0.0027465612355963 0.806930160604149 0.2190689419025454 12 Q16739,P04062,Q16880,Q13510,Q96G23,O95470,Q06136 7 +Sphingolipid metabolism in senescence 0.8067041159017163 2.988403635799017 0.0028043891974731 0.8135105594926394 0.2190689419025454 13 Q16739,P04062,Q13510,O15269,Q96G23,Q06136 6 +Nonalcoholic fatty liver disease 0.5724473477689923 2.975810674931169 0.0029221520093245 0.8262269322011763 0.2190689419025454 52 O14949,Q9P0J0,P20674,Q9UDW1,P22695,O43676,O95139,O14548,P14406,P08574,P00403,Q99643,Q86Y39,P13073,O95168,O95299,O96000,Q9Y6M9,P21912,P31751,P51970 21 +Sphingolipid metabolism overview 0.9069665261236348 2.906005824028175 0.0036607463527595 0.8884344583003718 0.2190689419025454 8 Q16739,Q16880,Q13510,Q96G23,O95470,Q06136 6 +Sphingolipid metabolism integrated pathway 0.8687852029799307 2.9057824746323355 0.003663360232484 0.88860935014779 0.2190689419025454 9 Q16739,Q16880,Q13510,Q96G23,O95470,Q06136 6 +Ferroptosis 0.6735971450306167 2.8118426835090573 0.004925858864234 0.9478140759863816 0.2530197397693753 21 P16435,P09601,P37268,P45880,Q9Y277,Q15043,P04035,Q9UKU0 8 +Mitochondrial complex iv assembly 0.809482639702187 2.8020869201327216 0.0050773191926964 0.9523546880790392 0.2530197397693753 11 P14406,Q8N8Q8,P13073,Q7KZN9,Q9Y2R0,O43819 6 +Copper homeostasis 0.8710052331030396 2.5820473453052077 0.0098216109897777 0.9972670027481452 0.2943733928608169 7 P04637,P05067,O43819,P35670,Q04656 5 +Overlap between signal transduction pathways contributing to lmna laminopathies 0.69166650964238 2.5687540723346327 0.0102064861832615 0.9978339279068148 0.2943733928608169 15 O75844,P02545,P50402,P49354,O60725,P42167 6 +Mitochondrial immune response to sarscov2 0.7935273840085962 2.5441347500155564 0.0109548814676891 0.9986220607185584 0.2943733928608169 9 Q86UT6,P35232,Q9Y6M9,Q99623 4 +Progeriaassociated lipodystrophy 0.7681479769692855 2.5022272116897786 0.0123414692130345 0.999404505280372 0.2943733928608169 10 O75844,P02545,P20700,P49354,O60725 5 +Metabolism of spingolipids in er and golgi apparatus 0.9250621890547254 2.4765096757423453 0.0132674028837471 0.9996601507073264 0.2943733928608169 5 Q06136,Q16880,O95470,Q16739 4 +Degradation pathway of sphingolipids including diseases 0.8672083702020004 2.4159093589461578 0.0156959680639265 0.9999221425958812 0.2943733928608169 6 P16278,O43681,P06280,P17900 4 +Familial partial lipodystrophy fpld 0.7899383232721117 2.362821097494096 0.0181364224266118 0.9999823563777448 0.3145869355515865 8 O75844,P02545,P20700,P49354,O60725 5 +Amyotrophic lateral sclerosis als 0.7504745673484324 2.3297548409997746 0.0198191122011921 0.999993674052222 0.3145869355515865 9 P07196,P04637,P07197,Q9BUN8 4 +Cholesterol metabolism with bloch and kandutschrussell pathways 0.5718264351794204 2.285848878449151 0.0222631010434835 0.999998578459532 0.3145869355515865 25 P33121,P53602,P35610,Q15392,P37268,Q14534,P04035,Q15800,P14324,Q16850,Q15125,P49327,Q9UBM7,Q14739,O00767 15 +Oxidative phosphorylation 0.558210120234587 2.26626932525431 0.0234348983391681 0.9999993060665588 0.3145869355515865 31 P06576,P56385,P24539,Q15904,O95168,O95299,O96000,O75787,O75964,Q86Y39,Q9Y6M9,P03886,O95139 13 +Acquired partial lipodystrophy barraquersimons syndrome 0.8672263681592016 2.2351888279952 0.0254049546310213 0.9999997925702152 0.3145869355515865 5 P49354,P02545,P20700,O60725 4 +Cholesterol biosynthesis with skeletal dysplasias 0.8253957623198673 2.2310419440774116 0.025678350771745 0.9999998246091836 0.3145869355515865 6 Q15392,Q16850,Q15125,Q14739 4 +Kennedy pathway from sphingolipids 0.8641169154228836 2.2220239528951624 0.0262816868908846 0.9999998789022306 0.3145869355515865 5 Q9UG56,O95470,Q9BVG9,P35790 4 +Influence of laminopathies on wnt signaling 0.6980973439870131 2.2218453802351115 0.0262937567021563 0.999999879796562 0.3145869355515865 11 O75844,P02545,P49354,O60725 4 +Mitochondrial complex iii assembly 0.7121013179052019 2.2127892824503785 0.0269121765269464 0.9999999177911056 0.3145869355515865 10 O14949,P22695,P08574,Q9UDW1 4 +Oxidation by cytochrome p450 0.8185900588327784 2.2005746195458236 0.0277661519987213 0.9999999513704088 0.3145869355515865 6 Q16850,O43169,Q6UW02 3 +Mitochondrial complex i assembly model oxphos system 0.5495279206073727 2.134824568704522 0.032775342639113 0.9999999977850652 0.3321975406472817 26 Q9P0J0,Q96CU9,O95168,O95299,O96000,P51970,Q9Y6M9,P03886,O43676,O95139 10 +Intracellular trafficking proteins involved in cmt neuropathy 0.7046856939761269 2.0955465872410186 0.0361224316360597 0.9999999997213364 0.3428764145772022 9 Q6UWE0,Q8TB36,Q9NR77,P07196 4 +Glycerophospholipid biosynthetic pathway 0.7283742646117738 2.0621523287378793 0.0391932356571473 0.9999999999586612 0.3549541391834906 8 O95674,Q9BTU6,Q9HCL2,O00116,O15228,P48651 6 +Glycerolipids and glycerophospholipids 0.7720446027117557 1.9893842597522624 0.0466588056630667 0.9999999999996104 0.3549541391834906 6 Q9UG56,Q9BVG9,Q9HCL2 3 +Statin inhibition of cholesterol production 0.741145345660619 1.980364351082204 0.0476626026709114 0.9999999999997924 0.3549541391834906 7 P37268,Q14534,Q8WTV0 3 +Triacylglyceride synthesis 0.7982742919533052 1.9387353425823608 0.0525335727768985 0.9999999999999905 0.3765113244348996 5 O00116,Q9NUQ2,Q9HCL2 3 +Proteoglycan biosynthesis 0.7976103110020043 1.9358352808134955 0.052887878348715 0.9999999999999922 0.3765113244348996 5 Q8NCH0,Q9NX62 2 +Glycosaminoglycan degradation 0.7555896340737542 1.913561483791575 0.0556762103995565 0.9999999999999988 0.3826939519417792 6 P06865,P16278,P34059,P54802 4 +Cholesterol biosynthesis pathway 0.5865567491904415 1.754022553325891 0.0794266427189755 1.0 0.469775608263866 13 P37268,Q14534,P04035,Q15800,Q16850,Q9UBM7 6 +Nephrotic syndrome 0.571771179177112 1.748004944580806 0.0804631712223045 1.0 0.469775608263866 14 O75844,P02545,Q14108 3 +Glucocorticoid receptor pathway 0.7401421920345665 1.681747629705765 0.0926177878068696 1.0 0.5176209075561502 5 P27105,Q13616 2 +Metapathway biotransformation phase i and ii 0.5049071811855628 1.6639412063503118 0.0961241792764069 1.0 0.5225659927935578 21 Q16850,Q8NCH0,Q6UW02,P21964 4 +Striated muscle contraction pathway 0.8018304658694883 1.5177712855254009 0.1290720662152031 1.0 0.6146216221157196 4 P08670 1 +Spinal cord injury 0.5103758255663523 1.5160677789859334 0.1295022146932787 1.0 0.6146216221157196 17 Q9NQC3,Q08722,P08670 3 +Ccl18 signaling pathway 0.5921017091209927 1.4929020541049831 0.1354628273849145 1.0 0.6292263123041291 9 P08670,P00403,P07196 3 +Camkk2 pathway 0.5856532274528717 1.4573328082671182 0.1450245346805516 1.0 0.6602440967626314 9 P09601 1 +S1p receptor signal transduction 0.6342275683530268 1.454437147077534 0.145825147339706 1.0 0.6602440967626314 7 Q13510,P04899,P31751 3 +Urea cycle and related diseases 0.9214041627834726 1.441189143676106 0.1495312545852503 1.0 0.6673111212088035 2 Q9UJS0 1 +Allograft rejection 0.5784260499622077 1.4173548184894276 0.1563792153400875 1.0 0.6890360061004238 9 P04439,Q9BY49,P08183,P10321,P08670,P49327 6 +Endothelin pathways 0.6187483748736844 1.3763850307578285 0.1687024599415425 1.0 0.6986380217717415 7 P42892,P16615 2 +Inclusion body myositis 0.905560733146936 1.3763399511886238 0.1687164095428399 1.0 0.6986380217717415 2 Q92542 1 +Adipogenesis 0.5207974428435036 1.35030677478646 0.176917600128168 1.0 0.7006405620969833 13 O75844 1 +Nucleotidebinding oligomerization domain nod pathway 0.6114736089630064 1.3395774044756965 0.1803827739102295 1.0 0.7013427162659119 7 Q7L5N1 1 +Mirna regulation of p53 pathway in prostate cancer 0.8878533706119911 1.3040057014927628 0.1922316384170139 1.0 0.7198512189643101 2 O14681 1 +Microrna network associated with chronic lymphocytic leukemia 0.8878533706119893 1.3040057014927555 0.1922316384170164 1.0 0.7198512189643101 2 Q07820 1 +7oxoc and 7betahc pathways 0.5384528031976961 1.253608394530887 0.2099843785290374 1.0 0.7305385833653292 10 P61916,Q15125,O15118 3 +Vitamin d metabolism 0.8626476072094345 1.240649199756732 0.2147353683146977 1.0 0.7305385833653292 3 P04062,P38435 2 +Ppar signaling pathway 0.4693701143224595 1.1991518714438372 0.2304688975564288 1.0 0.7535386353557667 16 P48163,Q9UKU0,P50416,O15254,P23786,O00767 6 +Alzheimers disease 0.3580394254779152 1.1738517657111724 0.2404544052841717 1.0 0.7583316060572998 83 O95197,P12236,P28072,P45880,Q9Y277,Q92542,Q9NQC3,P05067,P21796,P49721,P16615 11 +Calcium regulation in cardiac cells 0.4186335584605269 1.1160010213766498 0.2644216974080089 1.0 0.7858195156210491 25 P50148,P10644,P04899,P23634,P20020,P63218,P54709,P16615 8 +Alzheimers disease and mirna effects 0.3541200478596745 1.1136157878443569 0.2654440504271771 1.0 0.7858195156210491 84 P50148,O95197,Q8NE86,P12236,P28072,P05141,P45880,Q9Y277,Q92542,Q96IX5,Q9NQC3,Q9NSK0,P21796,P05067,P31751,P12235,P49721,P16615 18 +Mitochondrial complex ii assembly 0.8221776233812264 1.0855936633390038 0.2776588045040786 1.0 0.7945599346789541 3 P21912 1 +Caloric restriction and aging 0.8194768374728654 1.0753053778569073 0.2822380292684381 1.0 0.7945599346789541 3 P04637 1 +Photodynamic therapyinduced ap1 survival signaling 0.5592081934502037 1.0735773567916045 0.2830121506465171 1.0 0.7945599346789541 7 Q07820 1 +Envelope proteins and their potential roles in edmd physiopathology 0.4525546367778363 1.0538764980078086 0.2919394641828907 1.0 0.8082317930021486 15 O94901,Q9BTV4,P50402,P42166,Q8WXH0,Q14739,P42167 7 +Cellular proteostasis 0.688495200521528 1.0481081771228655 0.2945887692741586 1.0 0.8082317930021486 4 Q9UHV9,Q99471 2 +Vitamin d receptor pathway 0.4908761122181965 1.0354600639739442 0.3004541077110607 1.0 0.8111132212439539 11 Q96KA5,P20020,Q5VV42,Q92604 4 +Riboflavin and coq disorders 0.5709733042176868 1.0300187604091715 0.303001199009276 1.0 0.8111132212439539 6 Q86YH6,Q16134,O75208 3 +Vitamin dsensitive calcium signaling in depression 0.5496993359091775 1.0250699227555966 0.3053301961167305 1.0 0.8111132212439539 7 P20020,P23634 2 +Apoptosis modulation and signaling 0.4853083291631657 1.0022635014667105 0.316216345404376 1.0 0.8111132212439539 11 P04637,Q07820,O95831 3 +Omega3 omega6 fatty acid synthesis 0.5564627368048309 0.9594682156143388 0.3373229243124775 1.0 0.8335500361109983 6 P33121,O15254 2 +Omega9 fatty acid synthesis 0.5447697405769392 0.902781528220614 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0.4474952111393249 1.0 0.8802701850701193 13 Q9BY49,P50416,P40939,P23786,Q16836 5 +Tryptophan metabolism 0.4069194816926507 0.7460155855432736 0.4556580001842665 1.0 0.8875683521504605 15 Q15392,P40939,P51648 3 +Liver x receptor pathway 0.7433985709847742 0.7348349883129786 0.4624399956649765 1.0 0.8912446699697301 2 O00767 1 +Nanomaterial induced apoptosis 0.7433985709847698 0.7348349883129629 0.462439995664986 1.0 0.8912446699697301 2 O95831 1 +Fas ligand pathway and stress induction of heat shock proteins 0.4377591030182728 0.719866603487925 0.4716071320713855 1.0 0.8980149527473169 11 P02545,P20700 2 +Nuclear receptors in lipid metabolism and toxicity 0.7281764523143804 0.6792088731467875 0.4970055259224855 1.0 0.8980149527473169 2 P28288 1 +Lncrnamediated mechanisms of therapeutic resistance 0.7281764523143716 0.6792088731467549 0.4970055259225061 1.0 0.8980149527473169 2 P04637 1 +Fatty acid betaoxidation 0.3750205741734358 0.6547907104632648 0.5126025124287885 1.0 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osteogenesis imperfecta 0.3606671983023232 0.3189221081068131 0.7497855791947479 1.0 0.991625422167922 12 Q5JRA6,Q96AY3,P13674,P07237,O15460 5 +Fibrin complement receptor 3 signaling pathway 0.6113699906803272 0.3111055611248981 0.7557203736264064 1.0 0.9954202278162798 2 O14920 1 +Supression of hmgb1 mediated inflammation by thbd 0.5992544268406245 0.2807806343867422 0.7788786578736437 1.0 1.0 2 O14920 1 +Vitamin d in inflammatory diseases 0.4802611128380576 0.272179604033444 0.7854839236579085 1.0 1.0 4 O60244,O14920,Q16539 3 +Apoptosis 0.3606201349359988 0.2590116276664025 0.795626268983237 1.0 1.0 10 Q07820 1 +Factors and pathways affecting insulinlike growth factor igf1akt signaling 0.3775287892934966 0.2564088194073064 0.7976351785403508 1.0 1.0 8 P49770,Q15118,P42345,P06730,Q13418,P05556,P49841 7 +Sarscov2 b117 variant antagonises innate immune activation 0.5660142901522116 0.2069201418266573 0.8360722260195566 1.0 1.0 2 O94826 1 +Sars coronavirus and innate immunity 0.5582479030754776 0.1917048510674838 0.8479734058678627 1.0 1.0 2 Q7Z434 1 +Nodlike receptor nlr signaling pathway 0.557626592109346 0.1905215878569683 0.8489004283271031 1.0 1.0 2 O14920 1 +Pi3kaktmtor signaling pathway and therapeutic opportunities 0.3772939346811821 0.1709473224874003 0.8642651863180912 1.0 1.0 6 Q15382,Q15118,P42345,O00459,P49841 5 +Mammary gland development pathway pregnancy and lactation stage 3 of 4 0.4395399440472581 0.1631473147250481 0.870402447055463 1.0 1.0 4 P18031,P61201,P06753 3 +Gastric cancer network 2 0.3143157484302758 0.1608606111159039 0.8722031859934019 1.0 1.0 15 P04637,Q14739,Q03252 3 +Proteasome degradation 0.2954906413776953 0.1559412357501171 0.8760793414562211 1.0 1.0 40 Q9UL46,P04439,P61289,P28072,P10321,P49721,O00231 7 +Tca cycle in senescence 0.3507274953735491 0.1446289467705484 0.8850038413035648 1.0 1.0 8 P48163 1 +Target of rapamycin tor signaling 0.3336246207265504 0.13313480538839 0.8940867694300474 1.0 1.0 10 P04035 1 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0.935108211164164 1.0 1.0 2 P05771 1 +Genes controlling nephrogenesis 0.3336445689386794 0.0806567303327427 0.9357149488411648 1.0 1.0 8 Q12948,P11047,P35222,O94813,Q04721,Q13418,P05556 7 +Canonical and noncanonical notch signaling 0.4790307548928116 0.0805509959998426 0.9357990390224944 1.0 1.0 2 Q04721 1 +Hepatitis b infection 0.2877441539981357 0.0659186500958784 0.9474425922470536 1.0 1.0 21 Q9Y277 1 +Folatealcohol and cancer pathway hypotheses 0.4464119291705379 0.0557276620766104 0.9555587625885336 1.0 1.0 2 Q99707 1 +Photodynamic therapyinduced hif1 survival signaling 0.3166145548610795 0.0505199121070463 0.9597080820971806 1.0 1.0 9 Q07820 1 +Serotonin htr1 group and fos pathway 0.336367805359442 0.0358846713085651 0.9713743185195268 1.0 1.0 5 P04899 1 +Apoptosisrelated network due to altered notch3 in ovarian cancer 0.2933391597877167 0.0268702294198895 0.978563238421625 1.0 1.0 14 P08670,P05067 2 +Robo4 and vegf signaling pathways crosstalk 0.4139216904909981 0.0174981535191122 0.9860392059000104 1.0 1.0 3 O94813,P12931 2 +Angiopoietinlike protein 8 regulatory pathway 0.2776054210548634 0.014893043321779 0.9881175099332826 1.0 1.0 27 Q15382,Q9UPT5,P51812,P31751,O75955,P49327,Q14254,O00767 8 diff --git a/msigdb_wp/selections.json b/msigdb_wp/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..5c0acd7823209e975fc025b165bdd22cb30e74a7 --- /dev/null +++ b/msigdb_wp/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["15q112 copy number variation syndrome", "15q133 copy number variation syndrome", "16p112 distal deletion syndrome", "16p112 proximal deletion syndrome", "1q211 copy number variation syndrome", "22q112 copy number variation syndrome", "3q29 copy number variation syndrome", "4hydroxytamoxifen dexamethasone and retinoic acids regulation of p27 expression", "7oxoc and 7betahc pathways", "7q1123 copy number variation syndrome", "Ace inhibitor pathway", "Acetylcholine synthesis", "Acquired partial lipodystrophy barraquersimons syndrome", "Acute viral myocarditis", "Adipogenesis", "Aerobic glycolysis", "Aflatoxin b1 metabolism", "Agerage pathway", "Airway smooth muscle cell contraction", "Alanine and aspartate metabolism", "Allograft rejection", "Alpha 6 beta 4 signaling pathway", "Altered glycosylation of muc1 in tumor microenvironment", "Alternative pathway of fetal androgen synthesis", "Alzheimers disease", "Alzheimers disease and mirna effects", "Amino acid metabolism", "Amino acid metabolism pathway excerpt histidine catabolism extension", "Ampactivated protein kinase ampk signaling", "Amplification and expansion of oncogenic pathways as metastatic traits", "Amyotrophic lateral sclerosis als", "Androgen receptor signaling pathway", "Angiogenesis", "Angiopoietinlike protein 8 regulatory pathway", "Angiotensin ii receptor type 1 pathway", "Antiviral and antiinflammatory effects of nrf2 on sarscov2 pathway", "Apoptosis", "Apoptosis modulation and signaling", "Apoptosis modulation by hsp70", "Apoptosisrelated network due to altered notch3 in ovarian cancer", "Arachidonate epoxygenase epoxide hydrolase", "Arrhythmogenic right ventricular cardiomyopathy", "Aryl hydrocarbon receptor pathway wp2586", "Aryl hydrocarbon receptor pathway wp2873", "Aspirin and mirnas", "Atm signaling in development and disease", "Atm signaling pathway", "Atr signaling", "Autophagy", "Autosomal recessive osteopetrosis pathways", "B cell receptor signaling pathway", "Base excision repair", "Bdnftrkb signaling", "Benzene metabolism", "Benzoapyrene metabolism", "Bile acids synthesis and enterohepatic circulation", "Biogenic amine synthesis", "Biomarkers for pyrimidine metabolism disorders", "Biomarkers for urea cycle disorders", "Biotin metabolism including iems", "Bladder cancer", "Bmp signaling in eyelid development", "Bmp2wnt4foxo1 pathway in primary endometrial stromal cell differentiation", "Brainderived neurotrophic factor bdnf signaling pathway", "Breast cancer pathway", "Burn wound healing", "Calcium regulation in cardiac cells", "Caloric restriction and aging", "Camkk2 pathway", "Cancer immunotherapy by ctla4 blockade", "Cancer immunotherapy by pd1 blockade", "Cannabinoid receptor signaling", "Canonical and noncanonical notch signaling", "Canonical and noncanonical tgfb signaling", "Canonical nfkb pathway", "Cardiac hypertrophic response", "Cardiac progenitor differentiation", "Ccl18 signaling pathway", "Cell cycle", "Cell differentiation expanded index", "Cell differentiation index", "Cell migration and invasion through p75ntr", "Cells and molecules involved in local acute inflammatory response", "Celltype dependent selectivity of cck2r signaling", "Cellular proteostasis", "Cerebral organic acidurias including diseases", "Chemokine signaling pathway", "Cholesterol biosynthesis pathway", "Cholesterol biosynthesis with skeletal dysplasias", "Cholesterol metabolism with bloch and kandutschrussell pathways", "Chromosomal and microsatellite instability in colorectal cancer", "Ciliary landscape", "Ciliopathies", "Circadian rhythm genes", "Classical pathway of steroidogenesis with glucocorticoid and mineralocorticoid metabolism", "Clear cell renal cell carcinoma pathways", "Codeine and morphine metabolism", "Cohesin complex cornelia de lange syndrome", "Common pathways underlying drug addiction", "Complement and coagulation cascades", "Complement system", "Complement system in neuronal development and plasticity", "Congenital generalized lipodystrophy cgl", "Constitutive androstane receptor pathway", "Control of immune tolerance by vasoactive intestinal peptide", "Copper homeostasis", "Cori cycle", "Corticotropinreleasing hormone signaling pathway", "Cysteine and methionine catabolism", "Cytoplasmic ribosomal proteins", "Cytosine methylation", "Cytosolic dnasensing pathway", "Ddx1 as a regulatory component of the drosha microprocessor", "Degradation pathway of sphingolipids including diseases", "Development of pulmonary dendritic cells and macrophage subsets", "Development of ureteric collection system", "Disorders of folate metabolism and transport", "Disruption of postsynaptic signaling by cnv", "Dna damage response", "Dna damage response only atm dependent", "Dna irdamage and cellular response via atr", "Dna irdouble strand breaks and cellular response via atm", "Dna mismatch repair", "Dna repair pathways full network", "Dna replication", "Dopamine metabolism", "Dopaminergic neurogenesis", "Drug induction of bile acid pathway", "Dual hijack model of vif in hiv infection", "Ebola virus infection in host", "Ebsteinbarr virus lmp1 signaling", "Ectoderm differentiation", "Effect of progerin on genes involved in hutchinsongilford progeria syndrome", "Egfegfr signaling pathway", "Egfr tyrosine kinase inhibitor resistance", "Eicosanoid metabolism via cyclooxygenases cox", "Eicosanoid metabolism via cytochrome p450 monooxygenases pathway", "Eicosanoid metabolism via lipooxygenases lox", "Eicosanoid synthesis", "Electron transport chain oxphos system in mitochondria", "Embryonic stem cell pluripotency pathways", "Endochondral ossification", "Endochondral ossification with skeletal dysplasias", "Endoderm differentiation", "Endometrial cancer", "Endoplasmic reticulum stress response in coronavirus infection", "Endothelin pathways", "Energy metabolism", "Envelope proteins and their potential roles in edmd physiopathology", "Epithelial to mesenchymal transition in colorectal cancer", "Epo receptor signaling", "Erbb signaling pathway", "Erk pathway in huntingtons disease", "Estrogen metabolism", "Estrogen receptor pathway", "Estrogen signaling pathway", "Ethanol effects on histone modifications", "Eukaryotic transcription initiation", "Exerciseinduced circadian regulation", "Exrna mechanism of action and biogenesis", "Extracellular vesiclemediated signaling in recipient cells", "Extracellular vesicles in the crosstalk of cardiac cells", "Factors and pathways affecting insulinlike growth factor igf1akt signaling", "Familial hyperlipidemia type 1", "Familial hyperlipidemia type 2", "Familial hyperlipidemia type 3", "Familial hyperlipidemia type 4", "Familial hyperlipidemia type 5", "Familial partial lipodystrophy fpld", "Farnesoid x receptor pathway", "Fas ligand pathway and stress induction of heat shock proteins", "Fatty acid betaoxidation", "Fatty acid biosynthesis", "Fatty acid omegaoxidation", "Fatty acid transporters", "Fbxl10 enhancement of maperk signaling in diffuse large bcell lymphoma", "Ferroptosis", "Fgfr3 signaling in chondrocyte proliferation and terminal differentiation", "Fibrin complement receptor 3 signaling pathway", "Fluoroacetic acid toxicity", "Fluoropyrimidine activity", "Focal adhesion", "Focal adhesion pi3kaktmtorsignaling pathway", "Folate metabolism", "Folatealcohol and cancer pathway hypotheses", "Follicle stimulating hormone fsh signaling pathway", "Foxa2 pathway", "Foxp3 in covid19", "Fragile x syndrome", "Fto obesity variant mechanism", "G protein signaling pathways", "G1 to s cell cycle control", "G13 signaling pathway", "Gaba metabolism aka ghb", "Gaba receptor signaling", "Gammaglutamyl cycle for the biosynthesis and degradation of glutathione including diseases", "Ganglio sphingolipid metabolism", "Gastric cancer network 1", "Gastric cancer network 2", "Gastrin signaling pathway", "Gdnfret signaling axis", "Genes controlling nephrogenesis", "Genes related to primary cilium development based on crispr", "Genes targeted by mirnas in adipocytes", "Glial cell differentiation", "Glioblastoma signaling pathways", "Glucocorticoid receptor pathway", "Glucuronidation", "Glutathione metabolism", "Glycerolipids and glycerophospholipids", "Glycerophospholipid biosynthetic pathway", "Glycogen synthesis and degradation", "Glycolysis and gluconeogenesis", "Glycolysis in senescence", "Glycosaminoglycan degradation", "Glycosylation and related congenital defects", "Gpcrs class a rhodopsinlike", "Gpr143 in melanocytes and retinal pigment epithelium cells", "Gpr40 pathway", "H19 action rbe2f1 signaling and cdkbetacatenin activity", "Hair follicle development cytodifferentiation part 3 of 3", "Hair follicle development organogenesis part 2 of 3", "Head and neck squamous cell carcinoma", "Heart development", "Hedgehog signaling pathway wp4249", "Hedgehog signaling pathway wp47", "Hematopoietic stem cell gene regulation by gabp alphabeta complex", "Heme biosynthesis", "Hepatitis b infection", "Hepatitis c and hepatocellular carcinoma", "Hepatocyte growth factor receptor signaling", "Hereditary leiomyomatosis and renal cell carcinoma pathway", "Hif1a and pparg regulation of glycolysis", "Hijack of ubiquitination by sarscov2", "Hippo signaling regulation pathways", "Hippomerlin signaling dysregulation", "Hippoyap signaling pathway", "Histone modifications", "Homologous recombination", "Hostpathogen interaction of human coronaviruses apoptosis", "Hostpathogen interaction of human coronaviruses autophagy", "Hostpathogen interaction of human coronaviruses interferon induction", "Hostpathogen interaction of human coronaviruses mapk signaling", "Hypertrophy model", "Hypothesized pathways in pathogenesis of cardiovascular disease", "Id signaling pathway", "Il1 signaling pathway", "Il10 antiinflammatory signaling pathway", "Il17 signaling pathway", "Il18 signaling pathway", "Il2 signaling pathway", "Il3 signaling pathway", "Il4 signaling pathway", "Il5 signaling pathway", "Il6 signaling pathway", "Il7 signaling pathway", "Il9 signaling pathway", "Imatinib and chronic myeloid leukemia", "Immune response to tuberculosis", "Inclusion body myositis", "Inflammatory response pathway", "Influence of laminopathies on wnt signaling", "Inhibition of exosome biogenesis and secretion by manumycin a in crpc cells", "Initiation of transcription and translation elongation at the hiv1 ltr", "Insulin signaling", "Insulin signaling in adipocytes diabetic condition", "Insulin signaling in adipocytes normal condition", "Integrated cancer pathway", "Integrinmediated cell adhesion", "Interactions between immune cells and micrornas in tumor microenvironment", "Interactions between loxl4 and oxidative stress pathway", "Interactome of polycomb repressive complex 2 prc2", "Interferon type i signaling pathways", "Interleukin1 il1 structural pathway", "Interleukin1 induced activation of nfkb", "Interleukin11 signaling pathway", "Intracellular trafficking proteins involved in cmt neuropathy", "Intraflagellar transport proteins binding to dynein", "Irinotecan pathway", "Iron metabolism in placenta", "Joubert syndrome", "Kallmann syndrome", "Kennedy pathway from sphingolipids", "Ketogenesis and ketolysis", "Ketone bodies synthesis and degradation", "Kininkallikrein pathway", "Kisspeptinkisspeptin receptor system in the ovary", "Kit receptor signaling pathway", "Krebs cycle disorders", "Kynurenine pathway and links to cell senescence", "Leptin and adiponectin", "Leptin signaling pathway", "Leptininsulin signaling overlap", "Leukocyteintrinsic hippo pathway functions", "Linoleic acid metabolism affected by coronavirus infection", "Lipid metabolism pathway", "Lipid particles composition", "Liver x receptor pathway", "Lncrna in canonical wnt signaling and colorectal cancer", "Lncrnamediated mechanisms of therapeutic resistance", "Ltf danger signal response pathway", "Lung fibrosis", "Male infertility", "Malignant pleural mesothelioma", "Mammalian disorder of sexual development", "Mammary gland development pathway embryonic development stage 1 of 4", "Mammary gland development pathway involution stage 4 of 4", "Mammary gland development pathway pregnancy and lactation stage 3 of 4", "Mammary gland development pathway puberty stage 2 of 4", "Map3k1 role in promoting and blocking gonadal determination", "Mapk and nfkb signaling pathways inhibited by yersinia yopj", "Mapk cascade", "Mapk signaling pathway", "Matrix metalloproteinases", "Mbdnf and probdnf regulation of gaba neurotransmission", "Measles virus infection", "Mechanoregulation and pathology of yaptaz via hippo and nonhippo mechanisms", "Mecp2 and associated rett syndrome", "Melanoma", "Melatonin metabolism and effects", "Mesodermal commitment pathway", "Met in type 1 papillary renal cell carcinoma", "Metabolic pathway of ldl hdl and tg including diseases", "Metabolic reprogramming in colon cancer", "Metabolism of alphalinolenic acid", "Metabolism of spingolipids in er and golgi apparatus", "Metapathway biotransformation phase i and ii", "Metastatic brain tumor", "Methionine de novo and salvage pathway", "Methionine metabolism leading to sulfur amino acids and related disorders", "Methylation pathways", "Mevalonate arm of cholesterol biosynthesis pathway", "Mevalonate pathway", "Mfap5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement", "Mfap5mediated ovarian cancer cell motility and invasiveness", "Microglia pathogen phagocytosis pathway", "Microrna network associated with chronic lymphocytic leukemia", "Micrornas in cardiomyocyte hypertrophy", "Microtubule cytoskeleton regulation", "Mir124 predicted interactions with cell cycle and differentiation", "Mir517 relationship with arcn1 and usp1", "Mirna biogenesis", "Mirna regulation of dna damage response", "Mirna regulation of p53 pathway in prostate cancer", "Mirna regulation of prostate cancer signaling pathways", "Mirna targets in ecm and membrane receptors", "Mirnas involved in dna damage response", "Mirnas involvement in the immune response in sepsis", "Mitochondrial complex i assembly model oxphos system", "Mitochondrial complex ii assembly", "Mitochondrial complex iii assembly", "Mitochondrial complex iv assembly", "Mitochondrial fatty acid synthesis pathway", "Mitochondrial gene expression", "Mitochondrial immune response to sarscov2", "Mitochondrial long chain fatty acid betaoxidation", "Modulators of tcr signaling and t cell activation", "Molybdenum cofactor moco biosynthesis", "Monoamine transport", "Mrna processing", "Mrna protein and metabolite inducation pathway by cyclosporin a", "Mthfr deficiency", "Myd88 distinct inputoutput pathway", "Myometrial relaxation and contraction pathways", "Nad biosynthetic pathways", "Nad metabolism", "Nad metabolism in oncogeneinduced senescence and mitochondrial dysfunctionassociated senescence", "Nad metabolism sirtuins and aging", "Nanomaterial induced apoptosis", "Nanoparticle triggered autophagic cell death", "Nanoparticle triggered regulated necrosis", "Nanoparticlemediated activation of receptor signaling", "Ncrnas involved in stat3 signaling in hepatocellular carcinoma", "Ncrnas involved in wnt signaling in hepatocellular carcinoma", "Neovascularisation processes", "Nephrogenesis", "Nephrotic syndrome", "Netrinunc5b signaling pathway", "Network map of sarscov2 signaling pathway", "Neural crest cell migration during development", "Neural crest cell migration in cancer", "Neural crest differentiation", "Neurodegeneration with brain iron accumulation nbia subtypes pathway", "Neuroinflammation", "Neuroinflammation and glutamatergic signaling", "Nicotine effect on dopaminergic neurons", "Nipbl role in dna damage cornelia de lange syndrome", "Nitric oxide metabolism in cystic fibrosis", "Nocgmppkg mediated neuroprotection", "Nodlike receptor nlr signaling pathway", "Nonalcoholic fatty liver disease", "Nongenomic actions of 125 dihydroxyvitamin d3", "Nonhomologous end joining", "Nonsmall cell lung cancer", "Notch signaling", "Notch signaling pathway", "Notch1 regulation of endothelial cell calcification", "Novel intracellular components of rigilike receptor rlr pathway", "Nrf2 pathway", "Nrf2are regulation", "Nrp1triggered signaling pathways in pancreatic cancer", "Nsp1 from sarscov2 inhibits translation initiation in the host cell", "Nuclear receptors in lipid metabolism and toxicity", "Nuclear receptors metapathway", "Nucleotide excision repair", "Nucleotide excision repair in xeroderma pigmentosum", "Nucleotide metabolism", "Nucleotidebinding oligomerization domain nod pathway", "Oligodendrocyte specification and differentiation leading to myelin components for cns", "Omega3 omega6 fatty acid synthesis", "Omega9 fatty acid synthesis", "Oncostatin m signaling pathway", "Onecarbon metabolism", "Onecarbon metabolism and related pathways", "Orexin receptor pathway", "Osteoblast differentiation and related diseases", "Osteoclast signaling", "Osteopontin signaling", "Osx and mirnas in tooth development", "Ovarian infertility", "Overlap between signal transduction pathways contributing to lmna laminopathies", "Overview of interferonsmediated signaling pathway", "Overview of nanoparticle effects", "Oxidation by cytochrome p450", "Oxidative damage response", "Oxidative phosphorylation", "Oxidative stress response", "Oxysterols derived from cholesterol", "P38 mapk signaling pathway", "P53 transcriptional gene network", "Pancreatic adenocarcinoma pathway", "Parkinsons disease pathway", "Parkinubiquitin proteasomal system pathway", "Pathogenesis of sarscov2 mediated by nsp9nsp10 complex", "Pathogenic escherichia coli infection", "Pathways affected in adenoid cystic carcinoma", "Pathways of nucleic acid metabolism and innate immune sensing", "Pdgf pathway", "Pdgfrbeta pathway", "Pentose phosphate metabolism", "Pentose phosphate pathway in senescent cells", "Peroxiredoxin 2 induced ovarian failure", "Phase i biotransformations non p450", "Phosphodiesterases in neuronal function", "Phosphoinositides metabolism", "Photodynamic therapyinduced ap1 survival signaling", "Photodynamic therapyinduced hif1 survival signaling", "Photodynamic therapyinduced nfe2l2 nrf2 survival signaling", "Photodynamic therapyinduced nfkb survival signaling", "Photodynamic therapyinduced unfolded protein response", "Physicochemical features and toxicityassociated pathways", "Physiological and pathological hypertrophy of the heart", "Pi3kakt signaling pathway", "Pi3kaktmtor signaling pathway and therapeutic opportunities", "Pi3kaktmtor vitd3 signaling", "Pilocytic astrocytoma", "Pkcgamma calcium signaling pathway in ataxia", "Ppar signaling pathway", "Pparalpha pathway", "Praderwilli and angelman syndrome", "Pregnane x receptor pathway", "Preimplantation embryo", "Primary focal segmental glomerulosclerosis fsgs", "Prion disease pathway", "Progeriaassociated lipodystrophy", "Prolactin signaling pathway", "Prostaglandin and leukotriene metabolism in senescence", "Prostaglandin synthesis and regulation", "Proteasome degradation", "Proteoglycan biosynthesis", "Proximal tubule transport", "Ptf1a related regulatory pathway", "Purine metabolism", "Purine metabolism and related disorders", "Purinergic signaling", "Pyrimidine metabolism", "Pyrimidine metabolism and related diseases", "Quercetin and nfkb ap1 induced apoptosis", "Rac1pak1p38mmp2 pathway", "Rala downstream regulated genes", "Ranklrank signaling pathway", "Ras and bradykinin pathways in covid19", "Ras signaling", "Regucalcin in proximal tubule epithelial kidney cells", "Regulation of actin cytoskeleton", "Regulation of apoptosis by parathyroid hormonerelated protein", "Regulation of sister chromatid separation at the metaphaseanaphase transition", "Regulation of wnt bcatenin signaling by small molecule compounds", "Regulatory circuits of the stat3 signaling pathway", "Relationship between inflammation cox2 and egfr", "Reninangiotensinaldosterone system raas", "Resistin as a regulator of inflammation", "Retinoblastoma gene in cancer", "Rett syndrome causing genes", "Riboflavin and coq disorders", "Robo4 and vegf signaling pathways crosstalk", "S1p receptor signal transduction", "Sars coronavirus and innate immunity", "Sarscov2 altering angiogenesis via nrp1", "Sarscov2 and covid19 pathway", "Sarscov2 b117 variant antagonises innate immune activation", "Sarscov2 innate immunity evasion and cellspecific immune response", "Sarscov2 replication organelle formation", "Selenium micronutrient network", "Serine metabolism", "Serotonin and anxiety", "Serotonin and anxietyrelated events", "Serotonin htr1 group and fos pathway", "Serotonin receptor 2 and elksrfgata4 signaling", "Serotonin receptor 467 and nr3c signaling", "Serotonin transporter activity", "Signal transduction through il1r", "Sleep regulation", "Small cell lung cancer", "Smc1smc3 role in dna damage cornelia de lange syndrome", "Somatroph axis gh and its relationship to dietary restriction and aging", "Sphingolipid metabolism in senescence", "Sphingolipid metabolism integrated pathway", "Sphingolipid metabolism overview", "Sphingolipid pathway", "Spinal cord injury", "Splicing factor nova regulated synaptic proteins", "Srebf and mir33 in cholesterol and lipid homeostasis", "Statin inhibition of cholesterol production", "Steroid biosynthesis", "Sterol regulatory elementbinding proteins srebp signaling", "Sting pathway in kawasakilike disease and covid19", "Striated muscle contraction pathway", "Sudden infant death syndrome sids susceptibility pathways", "Sulfation biotransformation reaction", "Supression of hmgb1 mediated inflammation by thbd", "Synaptic signaling pathways associated with autism spectrum disorder", "Synaptic vesicle pathway", "T cell receptor and costimulatory signaling", "Target of rapamycin tor signaling", "Tca cycle aka krebs or citric acid cycle", "Tca cycle and deficiency of pyruvate dehydrogenase complex pdhc", "Tca cycle in senescence", "Tca cycle nutrient use and invasiveness of ovarian cancer", "Tcell activation sarscov2", "Tcell antigen receptor tcr pathway during staphylococcus aureus infection", "Tcell receptor tcr signaling pathway", "Tgfbeta receptor signaling", "Tgfbeta receptor signaling in skeletal dysplasias", "Tgfbeta signaling in thyroid cells for epithelialmesenchymal transition", "Tgfbeta signaling pathway", "Thermogenesis", "Thiamine metabolic pathways", "Thymic stromal lymphopoietin tslp signaling pathway", "Thyroid hormones production and peripheral downstream signaling effects", "Thyroid stimulating hormone tsh signaling pathway", "Tlr4 signaling and tolerance", "Tnfalpha signaling pathway", "Tnfrelated weak inducer of apoptosis tweak signaling pathway", "Tolllike receptor signaling pathway", "Tolllike receptor signaling related to myd88", "Tp53 network", "Transcription cofactors ski and skil protein partners", "Transcription factors regulate mirnas related to cardiac hypertrophy", "Transcriptional activation by nrf2 in response to phytochemicals", "Translation factors", "Translation inhibitors in chronically activated pdgfra cells", "Transsulfuration and onecarbon metabolism", "Transsulfuration pathway", "Triacylglyceride synthesis", "Tryptophan catabolism leading to nad production", "Tryptophan metabolism", "Tumor suppressor activity of smarcb1", "Type 2 papillary renal cell carcinoma", "Type i collagen synthesis in the context of osteogenesis imperfecta", "Type i interferon induction and signaling during sarscov2 infection", "Type ii diabetes mellitus", "Type ii interferon signaling ifng", "Type iii interferon signaling", "Tyrobp causal network in microglia", "Ultraconserved region 339 modulation of tumor suppressor micrornas in cancer", "Unfolded protein response", "Urea cycle and associated pathways", "Urea cycle and metabolism of amino groups", "Urea cycle and related diseases", "Valproic acid pathway", "Vasopressinregulated water reabsorption", "Vegfavegfr2 signaling pathway", "Vitamin a and carotenoid metabolism", "Vitamin b12 disorders", "Vitamin b12 metabolism", "Vitamin b6dependent and responsive disorders", "Vitamin d in inflammatory diseases", "Vitamin d metabolism", "Vitamin d receptor pathway", "Vitamin dsensitive calcium signaling in depression", "White fat cell differentiation", "Wnt signaling", "Wnt signaling in kidney disease", "Wnt signaling pathway", "Wnt signaling pathway and pluripotency", "Wntbetacatenin signaling pathway in leukemia", "Zinc homeostasis"], "available_proteins": ["AAR2", "AARS", "AASS", "ABCB1", "ABCC4", "ABCD3", "ABCF1", "ABCF2", "ACAA1", "ACAA2", "ACACA", "ACACB", "ACAD11", "ACAD9", "ACADM", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT8", "ACOT9", "ACOX1", "ACOX3", "ACP1", "ACP6", "ACSL1", "ACSL3", "ACSL4", "ACSL6", "ACTL6A", "ACTN1", "ACTN4", "ACTR2", "ACTR3", "ADA", "ADAR", "ADH5", "ADI1", "ADK", "ADRM1", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGL", "AGPAT1", "AGPAT5", "AGPS", "AHCTF1", "AHCY", "AHCYL1", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK4", "AKAP1", "AKAP10", "AKAP8", "AKAP9", "AKR1A1", "AKR1B1", "AKR7A2", "AKT2", "ALDH18A1", "ALDH1A2", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALG1", "ALG11", "AMOT", "ANAPC1", "ANAPC2", "ANAPC4", "ANAPC5", "ANAPC7", "ANK3", "ANLN", "ANP32A", "ANXA1", "ANXA2", "ANXA4", "ANXA6", "AP1G1", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "APEX1", "APMAP", "APP", "APPL1", "APRT", "ARCN1", "ARF4", "ARF6", "ARFGAP1", "ARFIP2", "ARG2", "ARHGDIA", "ARHGEF2", "ARID1A", "ARIH2", "ARL2", "ARL3", "ARPC1A", "ARPC2", "ARPC3", "ARPC4", "ARVCF", "ASAH1", "ASCC3", "ASNA1", "ASNS", "ATAD2", "ATG3", "ATG9A", "ATIC", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP2B4", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6AP1", "ATP6AP2", "ATP6V0D1", "ATP6V1A", "ATP6V1C1", "ATP6V1D", "ATP6V1E1", "ATP6V1H", "ATP7A", "ATP7B", "ATPAF1", "ATPIF1", "ATRIP", "ATXN10", "ATXN2L", "AURKA", "B3GALT6", "BAG2", "BAG3", "BAG4", "BAIAP2", "BANF1", "BARD1", "BAZ1A", "BAZ1B", "BCAS3", "BCKDK", "BCL2L12", "BCLAF1", "BCR", "BCS1L", "BLM", "BLVRA", "BPTF", "BRAP", "BRCA1", "BRD1", "BRD4", "BRIX1", "BSG", "BTAF1", "BTF3", "BUB1B", "BUB3", "BUD23", "C1QBP", "CAB39", "CACYBP", "CAD", "CALD1", "CALR", "CALU", "CAMK2G", "CAND1", "CANT1", "CAP1", "CAPN1", "CAPN2", "CAPNS1", "CAPZB", "CASK", "CBR1", "CBX1", "CBX2", "CBX3", "CBX5", "CC2D1A", "CCAR2", "CCDC6", "CCNB1", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2AP", "CD2BP2", "CD47", "CDC16", "CDC23", "CDC27", "CDC37", "CDC42", "CDC73", "CDCA5", "CDCA7L", "CDH2", "CDIPT", "CDK1", "CDK2", "CDK4", "CDK5", "CDK6", "CDK9", "CDKAL1", "CDKN2A", "CDS2", "CEBPZ", "CELF1", "CELF2", "CENPB", "CEP170", "CEP44", "CERS2", "CERS5", "CETN2", "CFL1", "CFL2", "CHAF1A", "CHAMP1", "CHD1", "CHD1L", "CHD4", "CHD8", "CHDH", "CHKA", "CHMP5", "CHORDC1", "CHRAC1", "CHST14", "CHTF18", "CIP2A", "CIT", "CKB", "CLASP1", "CLASP2", "CLCN7", "CLIC1", "CLPTM1L", "CLSPN", "CLTA", "CLTB", "CLTC", "CLUH", "CMPK1", "CNN2", "CNOT1", "CNOT9", "CNP", "COA3", "COL4A3BP", "COLEC12", "COLGALT1", "COMT", "COPG1", "COPS2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS8", "COQ8A", "COQ9", "COX15", "COX18", "COX2", "COX4I1", "COX5A", "COX5B", "COX6C", "COX7A2", "COX7A2L", "CPNE1", "CPOX", "CPSF1", "CPSF2", "CPSF3", "CPT1A", "CPT2", "CRK", "CRKL", "CRTAP", "CS", "CSK", "CSNK1A1", "CSNK2A1", "CSNK2A2", "CSNK2B", "CSRP2", "CSTB", "CSTF1", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTNNA1", "CTNNB1", "CTNND1", "CTPS1", "CTPS2", "CTR9", "CTSA", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4A", "CUL4B", "CUL5", "CXADR", "CYB5B", "CYB5R1", "CYB5R3", "CYC1", "CYFIP1", "CYFIP2", "CYP20A1", "CYP51A1", "DAGLB", "DARS", "DBNL", "DCAF1", "DCAF7", "DCTD", "DCTN1", "DCTN2", "DCTN4", "DCTPP1", "DDB1", "DDOST", "DDX1", "DDX17", "DDX20", "DDX21", "DDX3X", "DDX5", "DDX52", "DDX56", "DEK", "DERL1", "DFFA", "DHCR24", "DHCR7", "DHFR", "DHTKD1", "DHX15", "DHX16", "DHX29", "DHX36", "DHX38", "DHX8", "DHX9", "DIAPH1", "DIAPH3", "DICER1", "DLAT", "DLD", "DLG1", "DLGAP5", "DLST", "DNAAF5", "DNAJA1", "DNAJB1", "DNAJC3", "DNAJC7", "DNAJC8", "DNM1L", "DNM2", "DNMT1", "DPF2", "DPM1", "DPP9", "DPYSL2", "DSC3", "DSG2", "DSP", "DSTN", "DTX3L", "DTYMK", "DUSP3", "DUSP9", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNC2H1", "DYNLL1", "DYNLL2", "EBP", "ECE1", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECSIT", "EEA1", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EFTUD2", "EHBP1", "EHD1", "EI24", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF4A1", "EIF4A2", "EIF4B", "EIF4E", "EIF4E2", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAVL1", "ELL", "ELMOD2", "ELOA", "ELOB", "ELP3", "ELP4", "EMD", "EML4", "ENAH", "ENO1", "ENO2", "EPB41", "EPB41L2", "EPB41L3", "EPB41L5", "EPHX1", "EPHX2", "EPN1", "EPRS", "EPS15L1", "ERBIN", "ERCC2", "ERCC3", "ESD", "ETF1", "ETFA", "ETFDH", "EWSR1", "EXO1", "EXOC2", "EXOC3", "EXOC5", "EXOC6", "EXOC7", "EXOC8", "EXOSC2", "EXOSC7", "EXOSC9", "EZR", "F11R", "FADS2", "FAF1", "FAH", "FAM120A", "FANCD2", "FANCI", "FARSB", "FASN", "FAU", "FDFT1", "FDPS", "FECH", "FEN1", "FGFR1OP", "FH", "FHL1", "FHOD1", "FIS1", "FKBP10", "FKBP2", "FKBP4", "FKBP5", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FMR1", "FNTA", "FOXC1", "FOXRED1", "FSCN1", "FTO", "FUCA1", "FUS", "FXR1", "FXR2", "G3BP1", "G6PD", "GABARAPL2", "GALNS", "GALNT1", "GAPDH", "GART", "GBA", "GCDH", "GCLC", "GDAP1", "GDI1", "GFPT1", "GGCT", "GGCX", "GGH", "GID4", "GIGYF2", "GLA", "GLB1", "GLS", "GLUD1", "GM2A", "GNA13", "GNAI1", "GNAI2", "GNAI3", "GNAQ", "GNG12", "GNG5", "GNPAT", "GNS", "GOT1", "GOT2", "GPAM", "GPAT4", "GPD1L", "GPD2", "GPHN", "GPI", "GPS1", "GPT2", "GRB2", "GRSF1", "GSK3B", "GSR", "GSS", "GSTK1", "GSTM3", "GSTO1", "GSTZ1", "GTF2E1", "GTF2E2", "GTF2H1", "GTF2H4", "GTF2I", "GTPBP4", "GYG1", "GYS1", "H2AFY", "H2AFY2", "H4C1*", "HADH", "HADHA", "HADHB", "HAT1", "HCFC1", "HDAC1", "HDAC2", "HDGF", "HEBP1", "HELLS", "HEXA", "HEXB", "HGS", "HIBADH", "HIBCH", "HIRA", "HIRIP3", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLTF", "HMBS", "HMGA1", "HMGB1", "HMGB2", "HMGCL", "HMGCR", "HMGCS1", "HMOX1", "HNRNPA1", "HNRNPA2B1", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPK", "HNRNPL", "HNRNPM", "HNRNPR", "HNRNPU", "HPRT1", "HS2ST1", "HSD17B10", "HSD17B12", "HSD17B4", "HSD17B7", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA14", "HSPA1B", "HSPA2", "HSPA4", "HSPA8", "HSPA9", "HSPD1", "HTT", "HYOU1", "IARS", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDH3G", "IDI1", "IFT27", "IFT81", "IGBP1", "IGF2BP1", "IGF2BP3", "IKBKB", "ILF2", "ILK", "IMP3", "IMPAD1", "IMPDH1", "IMPDH2", "INF2", "INPP4A", "INPPL1", "IPO9", "IQCB1", "IQGAP1", "IQGAP3", "IRF2BPL", "IRS4", "ITCH", "ITGB1", "ITM2C", "ITPA", "IVD", "JUP", "KAT7", "KDM1A", "KDM1B", "KDM3B", "KDM5A", "KDSR", "KHDRBS1", "KHSRP", "KIDINS220", "KIF22", "KIF23", "KIF2C", "KIF3A", "KIF4A", "KIF5B", "KLC1", "KLC4", "KMT2A", "KPNA1", "KPNA4", "KPNB1", "KTN1", "L2HGDH", "LAMB1", "LAMC1", "LARP1", "LARP7", "LARS2", "LBR", "LDHA", "LDHB", "LDLR", "LEMD3", "LGALS3", "LGALS3BP", "LIG1", "LIG3", "LIN9", "LIPA", "LLGL1", "LMNA", "LMNB1", "LMNB2", "LPGAT1", "LRP1", "LRPPRC", "LRRC59", "LRRC8C", "LRSAM1", "LRWD1", "LSM2", "LSM4", "LSM7", "LSS", "LTA4H", "LUC7L", "LYN", "LZTFL1", "MACF1", "MAEA", "MAGT1", "MALT1", "MANF", "MAP1B", "MAP4", "MAPK1", "MAPK14", "MAPRE1", "MAPRE2", "MARS", "MARS2", "MAT2A", "MAT2B", "MAU2", "MAVS", "MBD3", "MCCC1", "MCCC2", "MCL1", "MCM10", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCU", "MDC1", "MDH1", "MDH2", "ME1", "ME2", "MECP2", "MED14", "MEPCE", "METTL3", "MFN2", "MGST2", "MGST3", "MIA3", "MIF", "MKI67", "MKLN1", "MMAB", "MOGS", "MORF4L1", "MOV10", "MPC2", "MPG", "MPI", "MPP1", "MPP2", "MPST", "MRE11", "MRPL19", "MRPL40", "MSH2", "MSH3", "MSH6", "MSMO1", "MSN", "MTA1", "MTA2", "MTAP", "MTCH1", "MTDH", "MTHFD1", "MTHFD1L", "MTHFD2", "MTHFS", "MTMR2", "MTMR6", "MTOR", "MTR", "MUT", "MVD", "MYBBP1A", "MYCBP", "MYCBP2", "MYEF2", "MYH10", "MYH9", "MYL6", "MYO1C", "MYO6", "NAA15", "NAA40", "NAA50", "NAE1", "NAGLU", "NAMPT", "NAP1L1", "NAPA", "NARS", "NAT10", "NBN", "NCAPG", "NCAPG2", "NCBP1", "NCDN", "NCKAP1", "NCL", "NCOR1", "NCSTN", "ND1", "NDUFA10", "NDUFA11", "NDUFA13", "NDUFA4", "NDUFA5", "NDUFA7", "NDUFA8", "NDUFA9", "NDUFAF2", "NDUFAF3", "NDUFAF4", "NDUFAF7", "NDUFB10", "NDUFB3", "NDUFB4", "NDUFB5", "NDUFB6", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS6", "NDUFS7", "NDUFS8", "NDUFV1", "NDUFV2", "NEDD4L", "NEFL", "NEFM", "NEK9", "NELFA", "NELFB", "NELFCD", "NELFE", "NF1", "NFATC2IP", "NIPBL", "NKRF", "NLRX1", "NME1", "NME2", "NONO", "NOP2", "NOTCH2", "NPC1", "NPC2", "NRP1", "NSD1", "NSDHL", "NSF", "NT5C3A", "NTHL1", "NUBPL", "NUDC", "NUDT21", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP214", "NUP62", "NUP88", "NUP98", "NXF1", "OAT", "OCLN", "OCRL", "OGDH", "OGT", "OPA1", "ORC2", "ORC3", "ORC5", "OXSR1", "P3H1", "P4HA1", "P4HA2", "P4HB", "PABPC1", "PABPN1", "PAF1", "PAFAH1B1", "PAICS", "PAK2", "PAPOLA", "PAPSS1", "PARD3", "PARK7", "PARN", "PARP1", "PARP2", "PBK", "PBRM1", "PC", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCM1", "PCNA", "PDCD6", "PDCD6IP", "PDE12", "PDHA1", "PDHB", "PDHX", "PDIA3", "PDIA6", "PDK1", "PDLIM5", "PDP1", "PDS5A", "PDS5B", "PDSS2", "PEBP1", "PECR", "PELO", "PFAS", "PFDN2", "PFDN4", "PFDN5", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGM3", "PGRMC2", "PHB", "PHB2", "PHF5A", "PHF6", "PHGDH", "PHKA1", "PHKB", "PI4K2A", "PI4KA", "PIGT", "PIK3C2A", "PIK3R2", "PIK3R4", "PIN1", "PIP4K2C", "PISD", "PKM", "PKMYT1", "PKN1", "PKN2", "PLCG1", "PLEC", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PMPCA", "PMVK", "PNKP", "PNP", "PNPLA8", "PNPT1", "POLA1", "POLA2", "POLD1", "POLD2", "POLDIP2", "POLE", "POLE2", "POLG", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2A", "POLR2B", "POLR2C", "POLR2D", "POLR2E", "POLR2G", "POLR2L", "POLR3A", "POLR3B", "POLR3C", "POLRMT", "PON2", "POR", "PPAT", "PPIB", "PPID", "PPIF", "PPM1G", "PPOX", "PPP1CA", "PPP1CB", "PPP1R10", "PPP1R7", "PPP1R8", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP2R5E", "PPP3CA", "PPP4R1", "PPP4R3A", "PPP5C", "PRCC", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PRIM1", "PRIM2", "PRKAA1", "PRKAA2", "PRKACA", "PRKAG1", "PRKAR1A", "PRKAR2A", "PRKCB", "PRKDC", "PRMT1", "PRMT3", "PRMT5", "PRPF3", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPS2", "PRRC2C", "PSAT1", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD6", "PSMD7", "PSMD8", "PSME1", "PSME2", "PSME3", "PSPC1", "PTBP1", "PTBP2", "PTDSS1", "PTDSS2", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK2", "PTPA", "PTPN1", "PTPN11", "PTPRF", "PTRH2", "PURA", "PUS1", "PXMP2", "PXN", "PYCR1", "PYCR2", "PYGB", "PYGL", "QKI", "RAB10", "RAB13", "RAB14", "RAB23", "RAB2A", "RAB3B", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RAB8A", "RAB9A", "RABGAP1", "RAC1", "RACGAP1", "RACK1", "RAD18", "RAD21", "RAD23A", "RAD23B", "RAD50", "RAE1", "RALA", "RAN", "RANBP1", "RANBP9", "RANGAP1", "RAPGEF2", "RARS", "RBBP4", "RBBP7", "RBM14", "RBM17", "RBM39", "RBM4", "RBM47", "RBM5", "RBMX", "RBPJ", "RCC1", "RCN1", "RDH14", "RDX", "RECQL", "RETSAT", "REXO2", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RHBDD2", "RHEB", "RHOG", "RIF1", "RIPK1", "RNASEH2A", "RNASET2", "RNF2", "RNF20", "RNF40", "RNMT", "RNPS1", "ROBO1", "ROCK1", "ROCK2", "RP2", "RPA1", "RPA2", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPN1", "RPN2", "RPP38", "RPRD1B", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS26", "RPS28", "RPS29", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RPTOR", "RRAS2", "RRBP1", "RRM1", "RRM2", "RTCB", "RTN3", "RTN4", "RUVBL1", "S100A11", "SACM1L", "SAFB", "SAMHD1", "SAP18", "SAR1A", "SAR1B", "SARS", "SCAF11", "SCAMP2", "SCARB1", "SCARB2", "SCD", "SCO1", "SCO2", "SCP2", "SCRIB", "SDHA", "SDHB", "SDHC", "SEC23A", "SEC23B", "SEC24A", "SEC24B", "SEC24C", "SEC31A", "SEL1L", "SEPT11", "SERBP1", "SERPINB6", "SERPINH1", "SET", "SETD1A", "SETD2", "SETD3", "SETDB1", "SEZ6L2", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SFPQ", "SFSWAP", "SGPL1", "SH3GL1", "SH3GLB1", "SHMT1", "SHMT2", "SIN3A", "SKP1", "SKP2", "SLC16A1", "SLC19A1", "SLC1A5", "SLC25A1", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A19", "SLC25A20", "SLC25A25", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A4", "SLC33A1", "SLC35B2", "SLC39A14", "SLC3A2", "SLC4A2", "SLC5A6", "SLC7A1", "SLIT2", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMS", "SND1", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNU13", "SNW1", "SOAT1", "SOD2", "SORT1", "SPEN", "SPNS1", "SPPL2A", "SPTAN1", "SPTBN1", "SPTLC1", "SPTLC2", "SQLE", "SRC", "SRCAP", "SREK1", "SRM", "SRP54", "SRPK1", "SRPK2", "SRRM1", "SRSF1", "SRSF10", "SRSF3", "SRSF4", "SRSF5", "SRSF7", "SRSF9", "SSR4", "STAG1", "STAG2", "STAM", "STAM2", "STAT1", "STAT3", "STIP1", "STK3", "STK4", "STMN1", "STOM", "STRAP", "STRN", "STUB1", "STX16", "STX4", "STXBP2", "STXBP3", "STXBP4", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGP2", "SUGT1", "SUN1", "SUPT5H", "SUZ12", "SYNE1", "SYNE2", "TAB1", "TAF6", "TALDO1", "TAP1", "TARDBP", "TBC1D4", "TBCA", "TBL1XR1", "TBL2", "TCP1", "TECR", "TELO2", "TERF2IP", "TFAM", "TFB1M", "TFCP2", "TFRC", "THRAP3", "TIGAR", "TJP1", "TJP2", "TK1", "TKT", "TLE3", "TLK2", "TLN1", "TMED10", "TMEM43", "TMOD3", "TMPO", "TMPO", "TNKS1BP1", "TNPO1", "TOMM40", "TOMM70", "TOP1", "TOP2A", "TOPBP1", "TOR1AIP1", "TP53", "TP53BP1", "TPI1", "TPM3", "TPM4", "TPP1", "TPX2", "TRA2A", "TRA2B", "TRAF2", "TRAP1", 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"ZMPSTE24", "ZNF281", "ZNF318", "ZYX"], "leading_proteins": ["ABCB1", "ABCD3", "ACOX3", "ACSL1", "ACSL6", "AGPAT5", "AGPS", "AIFM1", "AIP", "AKAP10", "AKAP8", "AKT2", "ALDH3A2", "ALG1", "APP", "ASAH1", "ASNA1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP2B4", "ATP5B", "ATP5F1", "ATP5I", "ATP5L", "ATP6AP1", "ATP6AP2", "ATP7A", "ATP7B", "BSG", "CD47", "CDC37", "CDKAL1", "CDS2", "CERS2", "CHKA", "CHST14", "CLPTM1L", "COA3", "COMT", "COPS2", "COPS6", "COQ9", "COX15", "COX18", "COX2", "COX4I1", "COX5A", "COX7A2", "COX7A2L", "CPT1A", "CPT2", "CTNNB1", "CUL1", "CYB5B", "CYC1", "CYP20A1", "CYP51A1", "DAGLB", "DERL1", "DHCR24", "DHCR7", "DLD", "EBP", "ECE1", "ECSIT", "EI24", "EIF2B2", "EIF4E", "EMD", "ETFDH", "EXOC7", "FASN", "FDFT1", "FDPS", "FGFR1OP", "FKBP10", "FLOT1", "FLOT2", "FNTA", "FOXC1", "FOXRED1", "GALNS", "GBA", "GDAP1", "GGCX", "GLA", "GLB1", "GM2A", "GNAI1", "GNAI2", "GNAQ", "GNG12", "GNG5", "GNPAT", "GPAM", "GSK3B", "HADH", "HADHA", "HEXA", "HLA-A", "HLA-C", "HMGCR", "HMOX1", "HSD17B4", 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sha256:1c02688d625defe8d09d55192783498df0fa4496a9771252bd6f5f4c93db4471 +size 136986 diff --git a/opencell_localization/basic/plot_3.png b/opencell_localization/basic/plot_3.png new file mode 100644 index 0000000000000000000000000000000000000000..61063ce3e79d025c04fd752814e30d51314d31dd --- /dev/null +++ b/opencell_localization/basic/plot_3.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:16f239dc6dc3dd3547a9b54457dbc190181683328e8f7d90f39a8d8bf87c2c0b +size 137782 diff --git a/opencell_localization/basic/plot_4.png b/opencell_localization/basic/plot_4.png new file mode 100644 index 0000000000000000000000000000000000000000..df844335fb07c5a20bc252cc18a2eb09088edf79 --- /dev/null +++ b/opencell_localization/basic/plot_4.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:5e4257bb5a36e5714014c9ad7d8583d81a44529cd57f838bc38e855dcd2dec33 +size 144761 diff --git a/opencell_localization/consensus.joblib b/opencell_localization/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..3d19600b5ffff86518347e85afadb63302a19ab6 --- /dev/null +++ b/opencell_localization/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:2de791c63ec8fb59b3a9abcba0559f87c68ef72246fee97fd3eaec667a23092e +size 73057 diff --git a/opencell_localization/df_merge.tsv b/opencell_localization/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..b9ba7fdac4f885ab969c8deb64603ea2717895ed --- /dev/null +++ b/opencell_localization/df_merge.tsv @@ -0,0 +1,3 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +er 49 85 4.652391858221632 3.2810681704908973e-06 29.17233009708738 87.61893203883496 1.3358083950399515 0.3757472714196316 13.465054065187209 8.223393744963309 2.0429537263872786 0.4010648005920765 3.4697598235498594e-21 0.0047018670886403 6.361576956114066e-05 3.928775717533492e-16 2.1203278036395472e-20 +mitochondria 8 11 2.910612784823629 0.0036072075116266 4.441747572815534 10.567961165048544 1.1937677940164793 0.2159787381789819 2.254231157409949 0.7391563798220593 1.4011905974754153 0.2980089661914649 0.0001094986389743 0.0607401038440192 0.0002296483500821 8.624555272386569e-06 8.104989222609044e-07 diff --git a/opencell_localization/metrics.json b/opencell_localization/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..92943170ae31ad29a61c5c93055459b037452ad2 --- /dev/null +++ b/opencell_localization/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3221, + "annotations_size": 17, + "title": "Average number of proteins per term", + "value": 95.47058823529412 +} \ No newline at end of file diff --git a/opencell_localization/paths.json b/opencell_localization/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..d1bc4f47aeedfacd0c068f2ebb85c69365a0dc80 --- /dev/null +++ b/opencell_localization/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/opencell_localization/fragment/C201/C201_val_log2fc"} \ No newline at end of file diff --git a/opencell_localization/result.tsv b/opencell_localization/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..2f15e219f97ed56d76dccbf447d6807fb084074e --- /dev/null +++ b/opencell_localization/result.tsv @@ -0,0 +1,6 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +er 0.7011270746179685 4.652391858221632 3.2810681704908973e-06 5.5776694826846805e-05 5.5778158898362255e-05 85 Q969V3,O00400,Q15363,Q15392,Q07065,Q9NR31,Q99640,Q96N66,Q9NQC3,Q5HYI8,Q9P2W9,Q15006,O15269,Q9UM00,O15173,Q9H6H4,P61026,O95674,Q9NPA0,Q16850,O95470,P04843,Q12981,Q9BVG9,P48651,Q969Q5,P84095,Q8NHH9,O60499,P27824,O96005,Q9Y3E0,Q15041,Q15125,Q9NTJ5,Q14739,O00767,Q00765,P49755,P51572,O75396,O75915,Q96A33,Q9Y487,O00264,Q9Y5M8,P46977,Q06136,Q8NF37 49 +mitochondria 0.8312168983818334 2.910612784823629 0.0036072075116266 0.0595844208467295 0.0204408425658845 11 Q969Q5,Q8IWA4,O95140,Q15388,Q9NVH1,Q9Y277,P45880,P21796 8 +golgi 0.3991323108346533 1.883298980226228 0.0596598615567074 0.6485653617526704 0.2535544116160066 66 Q8NBN3,Q9NR31,O75787,O15127,Q9UM00,O15126,O14735,P61026,Q9P289,Q8IZA0,Q5VW38,Q8N6T3,Q01968,P62820,P61019,P36543,Q9Y371,Q9Y3E0,Q7Z3C6,Q9NTJ5,P49755,Q15904,Q9H0U4,Q9Y487,Q8IXU6,O15258 26 +vesicles 0.4538018891336318 1.3079865383096565 0.1908778752665678 0.9726951808422756 0.4056154849414567 177 Q86Y82,Q969V3,O00400,Q8IY95,Q8IZ83,Q15363,Q9Y289,Q15392,Q9Y3E7,Q8NBN3,Q5HYI8,P20020,O75787,O15269,P56589,Q10713,O15127,P05023,Q9UM00,O15173,Q9H6H4,O15126,O14735,Q9Y5X3,P61026,O95674,P04439,Q8IZA0,Q5VW38,Q9UNK0,O95249,Q9H2V7,O95470,P51798,Q99747,O60749,Q01968,Q9H9H4,P62820,P11279,O60499,P61421,P61019,P53985,O15400,Q9Y371,P30825,O96005,Q96PE3,Q9Y3E0,Q7Z3C6,Q9UKR5,Q15125,Q96L92,O00767,Q567U6,Q93050,P49755,Q9BTU6,Q15904,O75396,O43808,Q9H0U4,Q9Y5K8,P31751,P13473,O00264,Q8IXU6,P11413,O15258,Q06136,Q8NF37 72 +nuclear_membrane 0.3714751100632242 0.7533717592185333 0.4512265482748416 0.999962873621897 0.5900654862055622 31 P02545,P52292,P20700,Q9C0E2,Q14739,P42167 6 diff --git a/opencell_localization/selections.json b/opencell_localization/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..cee3496a1cae6d32a0d105487daf1c4d78ba55db --- /dev/null +++ b/opencell_localization/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["big_aggregates", "cell_contact", "centrosome", "chromatin", "cytoplasmic", "cytoskeleton", "er", "focal_adhesions", "golgi", "membrane", "mitochondria", "nuclear_membrane", "nuclear_punctae", "nucleolus_fc_dfc", "nucleolus_gc", "nucleoplasm", "vesicles"], "available_proteins": ["AATF", "ABCE1", "ACLY", "ACTN1", "ACTN4", "ACTR2", "AHCY", "AHSA1", "AKAP8L", "AKR1A1", "AKT2", "ALDH16A1", "ALDH9A1", "ANAPC16", "ANAPC2", "ANAPC4", "ANKRD17", "ANXA11", "AP2B1", "AP2S1", "APPL1", "ARF4", "ARF6", "ARFGAP1", "ARFIP1", "ARFIP2", "ARHGAP17", "ARID1A", "ARL1", "ARL2", "ARL3", "ARL6IP1", "ARL6IP5", "ARL8A", "ARPC2", "ARPC3", "ATG3", "ATG9A", "ATL2", "ATP1A1", "ATP2B1", "ATP6AP1", "ATP6AP2", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1D", "ATP6V1E1", "ATP6V1H", "ATXN10", "ATXN2L", "BAG4", "BAG6", "BAIAP2", "BANF1", "BAZ1A", "BAZ1B", "BCAP31", "BLM", "BLVRA", "BMS1", "BNIP1", "BOP1", "BPNT1", "BRD2", "BRD4", "BTF3", "BUB1B", "BUD23", "BYSL", "C1orf123", "C8orf33", "CAD", "CALD1", "CAMK2G", "CANX", "CAPRIN1", "CAPZB", "CBX1", "CCAR1", "CCDC22", "CCDC47", "CCDC86", "CCDC93", "CCNB1", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2BP2", "CDC16", "CDC23", "CDC27", "CDC37", "CDC42", "CDH2", "CDIPT", "CDK1", "CDK12", "CDK2", "CDK4", "CDK5", "CDK9", "CDKN2A", "CDS2", "CEP170", "CEP72", "CERS5", "CETN2", "CHMP2B", "CHMP3", "CHMP4B", "CHMP7", "CKAP2", "CKAP4", "CKAP5", "CKB", "CLASP1", "CLASP2", "CLCN7", "CLINT1", "CLNS1A", "CLPTM1", "CLTA", "CLTB", "CLTC", "CNN2", "COIL", "COL4A3BP", "COPA", "COPB2", "COPE", "COPG1", "COPG2", "COPZ1", "CORO1B", "CORO1C", "CPSF6", "CSE1L", "CSK", "CSNK1A1", "CSNK2A1", "CSNK2A2", "CSNK2B", "CTBP1", "CTBP2", "CTNNB1", "CTNNBL1", "CTPS1", "CTTN", "CYB5R3", "CYP51A1", "DBNL", "DCP1B", "DCTN2", "DDB1", "DDOST", "DDX21", "DDX39B", "DDX47", "DDX5", "DDX56", "DDX6", "DHCR24", "DHX37", "DHX9", "DIAPH1", "DKC1", "DNAJA1", "DNAJA2", "DNAJB1", "DNAJC11", "DNAJC13", "DNAJC2", "DNAJC7", "DNAJC8", "DNAJC9", "DNM1L", "DNM2", "DOCK7", "DPH2", "DRG1", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNLL1", "DYNLL2", "EBNA1BP2", "EBP", "EDC3", "EDC4", "EDF1", "EEA1", "EEF1G", "EFTUD2", "EIF2AK2", "EIF3B", "EIF3E", "EIF3G", "EIF3I", "EIF3K", "EIF3M", "EIF4A1", "EIF4A3", "EIF5", "EMC1", "EMC2", "EMC7", "EMG1", "ENO1", "ENY2", "EPN1", "ERG28", "ESD", "ESYT1", "EWSR1", "EZR", "FAM120A", "FAM50A", "FARP1", "FASN", "FAU", "FBL", "FDPS", "FKBP5", "FKBP8", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAK", "GAPDH", "GAR1", "GBF1", "GDI1", "GDI2", "GET4", "GNL2", "GNL3", "GOLGA2", "GOLT1B", "GORASP2", "GOSR1", "GPAT4", "GPR107", "GRB2", "GSK3B", "GSPT1", "GTF2F1", "GTPBP4", "GYG1", "GYS1", "H1F0", "HDAC1", "HDAC2", "HEATR3", "HGS", "HLA-A", "HMGA1", "HMGB2", "HMGCS1", "HMGN2", "HNRNPA0", "HNRNPC", "HNRNPD", "HNRNPH1", "HNRNPL", "HNRNPU", "HSP90AA1", "HSP90AB1", "HSPA14", "HSPA1B", "HSPA4", "HSPA4L", "HSPA8", "HSPBP1", "HSPH1", "IDI1", "IGF2BP1", "IGF2BP3", "IKBKB", "ILF3", "ILK", "IMP3", "INPP4A", "INPPL1", "INTS14", "INTS9", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IST1", "ITSN2", "KDSR", "KIAA0319L", "KIAA0368", "KIF11", "KIF20A", "KIF22", "KIF2A", "KIF2C", "KIF3A", "KIF4A", "KIF5B", "KIFBP", "KLC1", "KLC4", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNA6", "KPNB1", "LAMP1", "LAMP2", "LARP7", "LBR", "LDHA", "LDHB", "LEMD3", "LIG1", "LMNA", "LMNB1", "LNPK", "LPCAT1", "LSM14B", "LSS", "LTV1", "MAP4", "MAPK1", "MAPK14", "MAPRE1", "MBOAT7", "MCM10", "MDH1", "MECP2", "MED14", "MED17", "MED22", "MED24", "MED4", "METAP2", "MFN1", "MFN2", "MIF", "MKI67", "MPHOSPH10", "MRTO4", "MSH6", "MSN", "MTMR2", "MTOR", "MVD", "MYBBP1A", "MYH10", "MYH9", "MYL6", "MYO1B", "MYO1C", "MYO6", "NAF1", "NANS", "NAPA", "NAPG", "NCAPH", "NCKAP1", "NCL", "NCLN", "NECAP2", "NEDD1", "NEK9", "NEMF", "NHP2", "NIFK", "NOL10", "NOL11", "NOM1", "NONO", "NOP2", "NOP53", "NOP58", "NPM1", "NRBP1", "NSA2", "NSDHL", "NUCKS1", "NUF2", "NUFIP2", "NUMA1", "NUP107", "NUP153", "NUP155", "NUP214", "NUP35", "NUP98", "NUTF2", "NVL", "NXF1", "OCRL", "OSBP", "OSBPL11", "OSBPL8", "OXSR1", "PABPC4", "PACSIN2", "PAK2", "PARP1", "PBK", "PCNA", "PDAP1", "PDCD11", "PDCD6", "PDCD6IP", "PDCL3", "PES1", "PEX3", "PFN1", "PGK1", "PGRMC1", "PGRMC2", "PHF10", "PHGDH", "PI4K2A", "PI4KA", "PI4KB", "PICALM", "PIK3C2A", "PIK3R2", "PIN4", "PIP4K2C", "PKM", "PKMYT1", "PKN1", "PKN2", "PLK1", "PMPCA", "PMVK", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2A", "POLR2B", "POLR2C", "POLR2D", "POLR2E", "POLR2G", "POLR3A", "POLR3B", "POLR3C", "PPM1G", "PRKAA1", "PRKACA", "PRKDC", "PRMT9", "PRPF19", "PRPF4B", "PRPF8", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD12", "PSMD13", "PSMD2", "PSMD3", "PSMD4", "PSMD6", "PSMD7", "PSME1", "PSME2", "PSME3", "PSME4", "PSMG1", "PSMG2", "PSMG3", "PSPC1", "PTDSS1", "PTDSS2", "PTGES3", "PTK2", "PTK7", "PXN", "RAB10", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB1B", "RAB23", "RAB24", "RAB2A", "RAB35", "RAB3GAP2", 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0.3201954718639376 2.5506648592929815 2.745113440103806 1.1546709449924732 0.3042666981599379 0.0291602574379564 0.1305522111527444 0.0026246094830452 0.0319451393300601 0.0498364179528963 +transporter 16 60 2.258428181969959 0.0239189773726611 16.281553398058254 57.34708737864078 1.7781248355514696 0.2510912048406951 6.627271511266295 3.5084386843827997 1.4364723564792363 0.3433005081320681 0.0002887164153491 0.1084777994315797 0.0053131066018268 0.0230184986659368 4.627877303276576e-05 +ATP synthase 7 20 2.230352362869199 0.0257240594556469 6.381067961165049 20.483009708737864 0.8573640874951715 0.3249378356888472 2.8850015270213047 1.3977105655851854 1.2517106680730556 0.3017789026221172 0.0002038979568293 0.1389130578490434 0.0354914601129098 0.0062346640440273 8.543393326442053e-05 +calmodulin-related 6 11 2.16465527931087 0.030414094244104 5.053398058252427 12.385922330097088 1.3935892727836532 0.1814075830019033 2.0222219603900085 1.786979844553702 1.206053991839631 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0.3835116962454471 0.6593661810718379 diff --git a/panther_protein_class/metrics.json b/panther_protein_class/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..abcb3725d542809fc3006c4a9059010b6c423ab8 --- /dev/null +++ b/panther_protein_class/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3221, + "annotations_size": 159, + "title": "Average number of proteins per term", + "value": 13.90566037735849 +} \ No newline at end of file diff --git a/panther_protein_class/paths.json b/panther_protein_class/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..376f29f8c1d8278485decda1f0ef3e87fcdab505 --- /dev/null +++ b/panther_protein_class/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/panther_protein_class/fragment/C201/C201_val_log2fc"} \ No newline at end of file diff --git a/panther_protein_class/result.tsv b/panther_protein_class/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..ba6ecb384ba062dfb38f8e91aee469cae70997e9 --- /dev/null +++ b/panther_protein_class/result.tsv @@ -0,0 +1,48 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +primary active transporter 0.7663102078317557 3.594974426426719 0.0003244234434183 0.0502834399374945 0.051583327503513 26 Q04656,P98194,Q8N4H5,Q9BUN8,Q15388,P23634,Q9NS69,P20020,P35670,O75381,Q6NTF9,Q6P4A7,O96008,P05023,Q9Y5J6,Q9GZP9,P16615,P54709 18 +membrane traffic protein 0.516713423383502 3.1273985060726974 0.0017636070009845 0.2447157223278291 0.0701033782891357 68 O60313,Q5JRA6,Q00765,Q9NX40,Q96PC5,P43307,P51572,Q96ED9,Q8N2H4,Q12768,P40855,Q9H6H4,O43493,Q96RL7,O00203 15 +secondary carrier transporter 0.7517150886073647 2.9670312105022543 0.003006904341859 0.3804847934199616 0.0956195580711168 16 O00400,Q96H78,Q9UJS0,O75746,Q9BQT8,P04920,Q8TB61,Q9UBX3,Q15043,Q96ES6,O95202 11 +mitochondrial carrier protein 0.8464120211860184 2.7999603429777093 0.0051108885021924 0.5572345062701535 0.1145705493266248 9 Q9BSK2,Q9HC21,Q6NUK1,Q70HW3,Q9NZJ7,P16260,Q6KCM7 7 +membrane trafficking regulatory protein 0.6775282686564863 2.7696398807353875 0.0056118301547203 0.5913082463575055 0.1145705493266248 20 O43760,P24390,P13473,Q14108,Q8WTV0 5 +oxidase 0.7636088467194253 2.760881662689558 0.0057645559409622 0.601168550863215 0.1145705493266248 13 P20674,P14406,O14548,P13073,O75880,O43819,Q15800 7 +oxygenase 0.8953550798923713 2.690225819453314 0.0071403683086843 0.6799862310117195 0.1261465067867571 7 Q16850,P30519,Q6UW02,P09601 4 +metalloprotease 0.6112770949698142 2.5915164832796145 0.0095553963953485 0.7827297690915659 0.1519308026860416 27 O75844,Q6P179,Q5JRX3,P52888,Q9UIQ6,Q9NZ08,P42892,P55786,O43847,Q99797,Q7Z2K6,Q8IYS1,Q10713,P22695,Q96TA2,P53582 16 +acyltransferase 0.6256336550147237 2.438113993374814 0.0147641173957018 0.9060503697697256 0.181939170170733 20 O15228,Q9HCL2,P49354,Q9NUQ2,P50416,Q92696,Q6UWP7,P14324,P23786,Q92604,Q8NF37 11 +transfer/carrier protein 0.6860510187276846 2.431645062657725 0.0150304282333293 0.910003117959686 0.181939170170733 14 Q9NZD2,P12236,P17900,P05141,O15127,P12235,Q9Y5M8,O14828,Q5T8D3 9 +glycosyltransferase 0.5903125007721424 2.3954675984213916 0.0165991812756423 0.930151044170642 0.181939170170733 23 Q8N4A0,Q16739,Q8N6G5,Q9BT22,Q8NBN7,Q96L58,Q10472,P46977 8 +SNARE protein 0.7417624836189386 2.285688992118348 0.022272459702094 0.9721620084754858 0.1880396465426558 9 O15400,Q9P2W9,O95249,O60499 4 +transporter 0.4564001123283726 2.258428181969959 0.0239189773726611 0.9787061990403476 0.1880396465426558 60 O60830,P52292,O43681,Q9NR77,Q8N8Q8,Q8TEX9,Q9H2D1,Q15070,O43615,Q9C0E2,P39210,Q9HD45,P53007,Q9H2V7,Q567V2,Q9Y619 16 +ATP synthase 0.5941582117234595 2.230352362869199 0.0257240594556469 0.9841352041660087 0.1880396465426558 20 P06576,Q93050,P56385,P24539,Q15904,Q9Y487,O75964 7 +calmodulin-related 0.6875361106066862 2.16465527931087 0.030414094244104 0.9926341865461448 0.1933289936076571 11 Q14257,P41208,O43852,Q02818,P80303,Q9BRK5 6 +ion channel 0.8479393644962765 2.153217736825912 0.0313015703547798 0.9936322395551996 0.1933289936076571 5 P51790,Q9C0H2,P51798 3 +oxidoreductase 0.5118792894321121 2.1206558751433295 0.0339507723325327 0.9958801446860568 0.1933289936076571 42 O14949,P16435,P48163,O95831,Q8N4Q0,Q9Y320,O95168,P00403,O96000,P09622,P51970,Q86Y39,Q9Y6M9,O15254,O43169,O43676 16 +transmembrane signal receptor 0.776327805605461 2.009022362210618 0.044534762246194 0.999285227787977 0.2284202321659628 6 Q99720,O75787,O15173,O00264 4 +heterotrimeric G-protein 0.6697545430198805 1.766185004042399 0.0773648160597557 0.9999972472173868 0.3075251438375291 8 P50148,P63218,Q8NHH9,P04899 4 +amino acid transporter 0.8430214485545424 1.686941635794024 0.0916145750803281 0.9999997682845374 0.3337654790722451 4 P30825,O14925,O60831 3 +voltage-gated ion channel 0.9770043505282772 1.6808311781151382 0.0927957108166654 0.9999998115873392 0.3337654790722451 3 P21796,P45880 2 +protein modifying enzyme 0.4878891016177708 1.6617591196610588 0.0965610819957438 0.9999999027457912 0.3337654790722451 25 P50897,Q86YN1,Q92791,Q6P2P2,P51812,O15460,O60725 7 +phospholipase 0.6280135355385287 1.550020723067768 0.1211365421746919 0.9999999987879968 0.3786307643181585 8 Q9Y6Y8,Q8IV08,Q8N2A8 3 +G-protein coupled receptor 0.8057196145477035 1.5338110917631878 0.1250761334699106 0.9999999994067034 0.3786307643181585 4 Q5VW38,Q8NBN3,P0CG08 3 +transferase 0.4679037432041163 1.5292186253725162 0.1262102547727195 0.9999999995172704 0.3786307643181585 28 O95674,P43490,Q8NBI6,Q8NCH0,P37268,Q2TAA5,Q7LGA3,P48651,Q9BVG9,Q99735 10 +galactosidase 0.9064926995961478 1.3801519222376983 0.1675398733968285 0.9999999999997824 0.4489940465128191 2 P16278 1 +kinase 0.4867936217697757 1.3545082644569166 0.1755742785273264 0.9999999999999536 0.4489940465128191 17 Q8WVC6,Q9BRR6,P35790,Q53H12 4 +chaperone 0.3411497767583404 1.151909162520878 0.2493584027179831 1.0 0.5506664726688795 69 Q9NWM8,Q96JJ7,P46379,Q96KC8,Q9NVH1,O95433,Q99471,Q7KZN9,O14656,Q15006,P27824,Q9UHV9,Q9Y2R0,Q9Y2G8,Q9BRT2,Q9Y680 16 +dehydrogenase 0.3333136141889162 1.028790667472282 0.3035780531271574 1.0 0.5886452493563176 71 Q9P0J0,Q3SXM5,Q8WWV3,Q9H9P8,Q9Y394,O43175,Q6YN16,Q96CU9,P51648,Q96LJ7,Q13423,P03886,Q9NZ01,P21912,O95139 15 +tubulin 0.5480559875583171 0.918693609223736 0.358255853478598 1.0 0.6311312705926784 6 Q13509,P07437,P04350,Q9BVA1,Q13885 5 +serine protease 0.4280309345860098 0.915176545463328 0.3600989555856513 1.0 0.6311312705926784 16 P67812,Q9HB40,P42785,O14773,P10619,Q8N2K0,Q9H3G5 7 +protein-binding activity modulator 0.5692046021214039 0.90301371465097 0.3665186161607419 1.0 0.6311312705926784 5 O14737 1 +aspartic protease 0.7333747669359696 0.755003629988133 0.4502468041825409 1.0 0.6913971259634293 3 Q8TCT8,Q8TCT9 2 +major histocompatibility complex protein 0.7097576134244725 0.6711850637814171 0.5021026425207611 1.0 0.739206668155565 3 P04439,P10321 2 +glycosidase 0.5134510396200016 0.6537947103131164 0.513244074896329 1.0 0.745497642332099 5 P06865 1 +small GTPase 0.4336396664420747 0.6499057776727828 0.5157530858901314 1.0 0.745497642332099 10 Q8IXI1,Q15382 2 +esterase 0.439767891427697 0.5543033529887663 0.5793712559980948 1.0 0.7741178966697234 8 Q969T7,Q9NUJ1 2 +damaged DNA-binding protein 0.5552343454315312 0.521449004096963 0.6020540216777728 1.0 0.7942942949702336 4 Q9NQE9,P54725 2 +microtubule binding motor protein 0.352523798891015 0.4896738937038393 0.6243646781519117 1.0 0.8137211789029012 20 O75935 1 +ATP-binding cassette (ABC) transporter 0.398130576156795 0.4531634900546988 0.6504310203014496 1.0 0.8207820018089721 10 Q03519,Q9NRK6,P28288,Q03518,Q9NP58,Q9NUT2 6 +nucleic acid metabolism protein 0.4508706467661608 0.3931590410849549 0.6942020193181235 1.0 0.8556443493921057 5 P49750,Q96FV9,Q9Y2W1,Q8IWR0 4 +nucleotide kinase 0.3424923571648404 0.2865228864729104 0.7744776670344664 1.0 0.8871646377722979 14 Q13126 1 +glucosidase 0.5679568185173236 0.2440113957604901 0.8072219941057936 1.0 0.8871646377722979 3 P10253 1 +kinase activator 0.5539155530422463 0.2118300694213075 0.8322396088087447 1.0 0.8891250780916331 3 P46020 1 +protease 0.302756138403412 0.2112419804766849 0.8326984540973994 1.0 0.8891250780916331 39 Q9BT78,P28072,P49721,Q9UJ14 4 +reductase 0.2991936462344369 0.1622903061829388 0.8710772480320725 1.0 0.9233418829139968 32 P31350,Q15392,P04035,Q9UDW1,Q9H7Z7,Q06136,Q14739 7 +methyltransferase 0.2841743693112339 0.0046572033762757 0.9962841027622412 1.0 1.0 15 P21964,Q9BV86 2 diff --git a/panther_protein_class/selections.json b/panther_protein_class/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..49fcd12aae2b7c4f81ea74976df1a57985fc9443 --- /dev/null +++ b/panther_protein_class/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["ATP synthase", "ATP-binding cassette (ABC) transporter", "C2H2 zinc finger transcription factor", "DNA glycosylase", "DNA helicase", "DNA ligase", "DNA metabolism protein", "DNA methyltransferase", "DNA polymerase processivity factor", "DNA topoisomerase", "DNA-binding transcription factor", "DNA-directed DNA polymerase", "DNA-directed RNA polymerase", "G-protein", "G-protein coupled receptor", "G-protein modulator", "GTPase-activating protein", "Hsp90 family chaperone", "P53-like transcription factor", "RNA helicase", "RNA metabolism protein", "RNA methyltransferase", "RNA processing factor", "RNA splicing factor", "SNARE protein", "acetyltransferase", "actin and actin related protein", "actin binding motor protein", "actin or actin-binding cytoskeletal protein", "acyltransferase", "aldolase", "amino acid kinase", "amino acid transporter", "aminoacyl-tRNA synthetase", "apolipoprotein", "aspartic protease", "basic helix-loop-helix transcription factor", "basic leucine zipper transcription factor", "cadherin", "calcium-binding protein", "calmodulin-related", "carbohydrate kinase", "cell adhesion molecule", "centromere DNA-binding protein", "chaperone", "chaperonin", "chromatin/chromatin-binding, or -regulatory protein", "cyclase", "cysteine protease", "cytokine", "cytoskeletal protein", "damaged DNA-binding protein", "deacetylase", "deaminase", "decarboxylase", "defense/immunity protein", "dehydratase", "dehydrogenase", "endodeoxyribonuclease", "endoribonuclease", "epimerase/racemase", "esterase", "exodeoxyribonuclease", "exoribonuclease", "extracellular matrix glycoprotein", "extracellular matrix protein", "extracellular matrix structural protein", "galactosidase", "general transcription factor", "glucosidase", "glycosidase", "glycosyltransferase", "growth factor", "guanyl-nucleotide exchange factor", "heterotrimeric G-protein", "histone", "histone modifying enzyme", "homeodomain transcription factor", "hydratase", "hydrolase", "hydroxylase", "immunoglobulin superfamily cell adhesion molecule", "integrin", "intercellular signal molecule", "intermediate filament binding protein", "ion channel", "isomerase", "kinase", "kinase activator", "kinase inhibitor", "kinase modulator", "ligase", "lipase", "lyase", "mRNA capping factor", "mRNA polyadenylation factor", "major histocompatibility complex protein", "membrane traffic protein", "membrane trafficking regulatory protein", "metalloprotease", "methyltransferase", "microtubule binding motor protein", "microtubule or microtubule-binding cytoskeletal protein", "mitochondrial carrier protein", "mutase", "non-motor actin binding protein", "non-motor microtubule binding protein", "non-receptor serine/threonine protein kinase", "nucleic acid metabolism protein", "nucleotide kinase", "nucleotide phosphatase", "nucleotidyltransferase", "oxidase", "oxidoreductase", "oxygenase", "peptide hormone", "peroxidase", "phosphatase", "phosphatase activator", "phosphatase modulator", "phosphodiesterase", "phospholipase", "primary active transporter", "primase", "protease", "protease inhibitor", "protein modifying enzyme", "protein phosphatase", "protein-binding activity modulator", "pyrophosphatase", "reductase", "replication origin binding protein", "ribosomal protein", "scaffold/adaptor protein", "secondary carrier transporter", "serine protease", "small GTPase", "structural protein", "tight junction", "transaminase", "transcription cofactor", "transfer/carrier protein", "transferase", "transketolase", "translation elongation factor", "translation factor", "translation initiation factor", "translation release factor", "translational protein", "transmembrane signal receptor", "transporter", "tubulin", "tyrosine protein kinase receptor", "ubiquitin-protein ligase", "vesicle coat protein", "viral or transposable element protein", "voltage-gated ion channel", "winged helix/forkhead transcription factor", "zinc finger transcription factor"], "available_proteins": ["AAR2", "AARS", "AARS2", "AASDHPPT", "AASS", "AATF", "ABCB1", "ABCB10", "ABCB6", "ABCB7", "ABCB8", "ABCC4", "ABCD3", "ABCF1", "ABCF2", "ABCF3", "ABHD10", "ABHD12", "ABHD6", "ACAA1", "ACAA2", "ACAD11", "ACAD9", "ACADM", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACBD5", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT8", "ACOT9", "ACOX1", "ACOX3", "ACP1", "ACP2", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACSL6", "ACTL6A", "ACTR1A", "ACTR1B", "ACTR2", "ACTR3", "ACTR8", "ADA", "ADAR", "ADD1", "ADD3", "ADH5", "ADI1", "ADPGK", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGK", "AGPAT1", "AGPAT5", "AHCTF1", "AHCY", "AHCYL1", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AK3", "AK4", "AK6", "AKAP1", "AKAP10", "AKAP8", "AKAP8L", "AKR1A1", "AKR1B1", "AKR7A2", "AKT2", "ALDH16A1", "ALDH18A1", "ALDH1A2", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALG1", "ALG11", "ALG5", "ALKBH5", "ALYREF", "ANAPC1", "ANAPC7", "ANGEL1", "ANKFY1", "ANKHD1", "ANKRD17", "ANLN", "ANP32A", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA4", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP1M1", "AP1S1", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "APEH", "APP", "APPL1", "APRT", "ARCN1", "ARF4", "ARF6", "ARFGAP1", "ARFIP1", "ARFIP2", "ARG2", "ARHGDIA", "ARID3B", "ARIH2", "ARL1", "ARL6IP5", "ARPC1A", "ARPC3", "ARPC4", "ARVCF", "ASAH1", "ASB6", "ASCC3", "ASH2L", "ASNA1", "ASNS", "ASPH", "ATAD2", "ATAD5", "ATG3", "ATL2", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP2B4", "ATP2C1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6AP1", "ATP6AP2", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1D", "ATP6V1H", "ATP7A", "ATP7B", "ATPAF1", "ATPIF1", "ATXN2L", "AUP1", "AURKA", "B3GALT6", "B4GAT1", "BAG2", "BAG6", "BAIAP2", "BAP18", "BAZ2A", "BCAP31", "BCAS2", "BCKDK", "BCLAF1", "BCR", "BLM", "BLMH", "BLVRA", "BOP1", "BPNT1", "BRCA1", "BRD1", "BRIX1", "BSG", "BTF3", "BUB1B", "BUB3", "BUD23", "BUD31", "BZW1", "BZW2", "CACYBP", "CAD", "CALD1", "CALR", "CALU", "CAMK2G", "CAND1", "CAND2", "CANT1", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPRIN1", "CAPZA1", "CAPZB", "CARHSP1", "CARS", "CASK", "CAST", "CBR1", "CBX8", "CCAR1", "CCAR2", "CCNB1", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2BP2", "CD3EAP", "CD47", "CDC16", "CDC23", "CDC27", "CDC37", "CDC42", "CDH2", "CDIPT", "CDK1", "CDK12", "CDK2", "CDK4", "CDK5", "CDK6", "CDK9", "CDKN2AIP", "CDS2", "CEBPZ", "CENPB", "CEP170", "CETN2", "CFL1", "CFL2", "CHAF1A", "CHAF1B", "CHDH", "CHERP", "CHKA", "CHMP2B", "CHMP3", "CHMP4B", "CHMP5", "CHMP7", "CHORDC1", "CHRAC1", "CHST14", "CHTF18", "CHTOP", "CIT", "CKAP2", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLASP2", "CLCC1", "CLCN3", "CLCN7", "CLGN", "CLIC1", "CLNS1A", "CLPB", "CLPP", "CLPX", "CLTA", "CLTB", "CLTC", "CLUH", "CMAS", "CMPK1", "CNDP2", "CNN2", "CNN3", "CNOT1", "CNOT4", "CNP", "COA3", "COG4", "COIL", "COL4A3BP", "COLEC12", "COLGALT1", "COMT", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS8", "COPZ1", "CORO1B", "CORO1C", "CORO7", "COTL1", "COX15", "COX18", "COX2", "COX4I1", "COX5A", "COX5B", "COX7A2", "COX7A2L", "CPD", "CPOX", "CPSF1", "CPSF3", "CPSF6", "CPSF7", "CPT1A", "CPT2", "CPVL", "CRK", "CRKL", "CRNKL1", "CRTAP", "CRYZ", "CS", "CSE1L", "CSGALNACT2", "CSNK1A1", "CSNK2B", "CSRP2", "CSTB", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTNNA1", "CTNND1", "CTPS1", "CTPS2", "CTR9", "CTSA", "CTSC", "CTTN", "CTU2", "CUL1", "CUL2", "CUL3", "CUL4A", "CUL4B", "CUL5", "CUTA", "CWC22", "CYB5B", "CYB5R1", "CYB5R3", "CYFIP1", "CYFIP2", "CYP20A1", "CYP51A1", "DAGLB", "DAP3", "DARS", "DARS2", "DBN1", "DBNL", "DBT", "DCAF13", "DCAF8", "DCAKD", "DCP1B", "DCPS", "DCTD", "DCTN1", "DCTN2", "DCTN3", "DCTN4", "DCTPP1", "DCXR", "DDB1", "DDI2", "DDOST", "DDT", "DEK", "DENR", "DERL1", "DERL2", "DHCR24", "DHCR7", "DHFR", "DHRS1", "DHRS13", "DHRS7", "DHRS7B", "DHTKD1", "DHX15", "DHX16", "DHX29", "DHX30", "DHX36", "DHX37", "DHX38", "DHX40", "DHX57", "DHX8", "DHX9", "DIDO1", "DIEXF", "DIMT1", "DIS3", "DKC1", "DLAT", "DLD", "DLG1", "DLGAP5", "DLST", "DMAP1", "DNAAF5", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC13", "DNAJC16", "DNAJC2", "DNAJC21", "DNAJC7", "DNAJC8", "DNAJC9", "DNM1L", "DNM2", "DNMT1", "DNPH1", "DOCK7", "DOHH", "DOLPP1", "DPF2", "DPH5", "DPM1", "DPP3", "DPP9", "DPYSL2", "DPYSL3", "DPYSL5", "DSC3", "DSCR3", "DSG2", "DSP", "DST", "DSTN", "DTX3L", "DTYMK", "DUS2", "DUSP12", "DUSP9", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNC2H1", "DYNLL1", "DYNLL2", "EARS2", "EBP", "ECE1", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "ECSIT", "EDC4", "EEA1", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF2", "EFL1", "EFTUD2", "EHD1", "EHD4", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2D", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF4B", "EIF4E", "EIF4E2", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAC2", "ELAVL1", "ELL", "ELMO2", "ELMOD2", "ELOB", "ELP1", "ELP3", "EMC2", "EMG1", "ENAH", "ENO1", "ENO2", "ENY2", "EPHA7", "EPHX1", "EPHX2", "EPPK1", "EPRS", "EPS15L1", "ERAL1", "ERAP1", "ERAP2", "ERBIN", "ERC1", "ERCC2", "ERCC3", "ERH", "ERMP1", "ERO1A", "ERO1B", "ERP29", "ESD", "ETF1", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXO1", "EXOC3", "EXOC5", "EXOC6", "EXOC7", "EXOSC1", "EXOSC2", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC8", "EXOSC9", "EZR", "FAHD1", "FAHD2A", "FAM98A", "FAM98B", "FARSA", "FARSB", "FBL", "FDFT1", "FDPS", "FDXR", "FECH", "FEN1", "FH", "FKBP14", "FKBP3", "FKBP4", "FKBP5", "FKBP7", "FKBP8", "FLAD1", "FLII", "FMR1", "FNDC3A", "FNTA", "FNTB", "FOXC1", "FOXRED1", "FRYL", "FSCN1", "FSD1", "FTO", "FTSJ3", "FUBP1", "FUBP3", "FUCA1", "FUCA2", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GAK", "GALK1", "GALM", "GALNS", "GALNT1", "GALNT2", "GALNT4", "GALNT7", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GATAD2A", "GATAD2B", "GATB", "GBF1", "GCAT", "GCDH", "GCFC2", "GCLC", "GCN1", "GDI1", "GDI2", "GDPD1", "GFPT1", "GGH", "GGT7", "GINS2", "GLA", "GLB1", "GLCE", "GLDC", "GLE1", "GLMN", "GLO1", "GLRX3", "GLRX5", "GLS", "GLTP", "GLUD1", "GLYR1", "GM2A", "GMFB", "GMPS", "GNA13", "GNAI1", "GNAI2", "GNAI3", "GNAQ", "GNE", "GNG12", "GNG5", "GNPAT", "GNPDA1", "GNPNAT1", "GNS", "GOLGA2", "GOLGA3", "GOLT1B", "GOSR1", "GOT1", "GOT2", "GPAM", "GPAT4", "GPATCH4", "GPD1L", "GPD2", "GPI", "GPKOW", "GPR107", "GPR108", "GPR89B", "GPRASP2", "GPT2", "GPX8", "GRHPR", "GRPEL1", "GRSF1", "GSK3B", "GSPT1", "GSR", "GSS", "GSTK1", "GSTM3", "GSTZ1", "GTF2E1", "GTF2E2", "GTF2F1", "GTF2H1", "GTF2H4", "GTF2I", "GTF3C1", "GTF3C3", "GTF3C4", "GTF3C5", "GTPBP1", "GTPBP3", "GUF1", "GYG1", "H1F0", "H1FX", "H2AFY", "H2AFY2", "H4C1*", "HACL1", "HADHB", "HARS2", "HAT1", "HBS1L", "HCCS", "HDGF", "HDGFL2", "HDGFL3", "HDHD2", "HDHD5", "HDLBP", "HEATR1", "HECTD1", "HECTD3", "HEXA", "HEXB", "HIBADH", "HIBCH", "HINT2", "HINT3", "HIRA", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HM13", "HMBS", "HMGA1", "HMGCL", "HMGCR", "HMGN2", "HMOX1", "HMOX2", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPM", "HNRNPR", "HOOK2", "HOOK3", "HP1BP3", "HPRT1", "HS2ST1", "HSD17B10", "HSD17B7", "HSDL1", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPE1", "HTATSF1", "HUWE1", "IARS", "IARS2", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDH3G", "IDI1", "IGBP1", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IK", "IKBKB", "ILF2", "ILF3", "ILK", "ILKAP", "ILVBL", "IMP3", "IMP4", "IMPAD1", "IMPDH1", "IMPDH2", "INTS11", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IQGAP3", "IRF2BPL", "ISG20L2", "ISOC1", "ISY1", "ISYNA1", "ITCH", "ITGB1", "ITPA", "ITPK1", "ITSN2", "IVD", "JMJD6", "KARS", "KAT7", "KCTD12", "KDELR1", "KDM1A", "KDM1B", "KDM3B", "KDM5A", "KDSR", "KHDRBS1", "KHDRBS3", "KHSRP", "KIAA0368", "KIF11", "KIF14", "KIF18A", "KIF18B", "KIF1A", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF3A", "KIF4A", "KIF5B", "KLC1", "KLC4", "KLHL11", "KMT2A", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNA6", "KPNB1", "KRR1", "KYAT3", "L2HGDH", "L3HYPDH", "LAMB1", "LAMC1", "LAMP1", "LAMP2", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LBR", "LCLAT1", "LDAH", "LDHA", "LDHB", "LDLR", "LETM1", "LGALS3", "LGMN", "LIG1", "LIG3", "LIMA1", "LIN9", "LIPA", "LLGL1", "LMAN2", "LMAN2L", "LNPEP", "LONP1", "LPCAT1", "LPGAT1", "LRP1", "LRPAP1", "LRRC40", "LRRC47", "LRRC59", "LRRC8C", "LRWD1", "LSM14B", "LSM2", "LSM4", "LSM6", "LSM7", "LSS", "LTN1", "LYAR", "LYPLA1", "LZTFL1", "M6PR", "MACF1", "MAGED2", "MAGT1", "MALT1", "MAP1A", "MAP1B", "MAP1S", "MAP7D1", "MAPK1", "MAPK14", "MAPRE1", "MAPRE2", "MARCH5", "MARS", "MARS2", "MAT2A", "MAT2B", "MBOAT7", "MCAM", "MCCC1", "MCCC2", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MDH1", "MDH2", "ME1", "ME2", "MECP2", "MED14", "MED17", "MED22", "MED23", "MED24", "MED4", "METAP1", "METAP2", "METTL13", "METTL3", "METTL7B", "MFSD3", "MFSD5", "MGEA5", "MGST2", "MGST3", "MIA2", "MIA3", "MICU1", "MIF", "MINPP1", "MIPEP", "MKRN2", "MMAB", "MMS19", "MOGS", "MON2", "MORF4L1", "MORF4L2", "MPG", "MPHOSPH10", "MPI", "MPP1", "MPP2", "MPP6", "MPP7", "MPRIP", "MPST", "MPV17", "MPV17L2", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL14", "MRPL15", "MRPL17", "MRPL19", "MRPL2", "MRPL20", "MRPL21", "MRPL22", "MRPL24", "MRPL28", "MRPL3", "MRPL37", "MRPL38", "MRPL39", "MRPL40", "MRPL41", "MRPL43", "MRPL44", "MRPL45", "MRPL46", "MRPL47", "MRPL48", "MRPL49", "MRPL50", "MRPL53", "MRPL58", "MRPL9", "MRPS11", "MRPS16", "MRPS18A", "MRPS22", "MRPS23", "MRPS25", "MRPS27", "MRPS28", "MRPS30", "MRPS31", "MRPS33", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRPS9", "MRRF", "MSH2", "MSH3", "MSH6", "MSMO1", "MSN", "MTA1", "MTA2", "MTAP", "MTCH1", "MTCH2", "MTHFS", "MTMR14", "MTMR2", "MTMR6", "MTOR", "MTPAP", "MUT", "MVD", "MYBBP1A", "MYCBP", "MYCBP2", "MYDGF", "MYEF2", "MYG1", "MYL6", "MYO1B", "MYO1C", "MYO1D", "MYO6", "NAA10", "NAA15", "NAA25", "NAA35", "NAA50", "NAE1", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NAPG", "NARS", "NASP", "NAT10", "NAXE", "NBN", "NCAPD2", "NCAPD3", "NCBP1", "NCDN", "NCEH1", "NCKIPSD", "NCOA5", "NCOR1", "ND1", "NDC80", "NDRG3", "NDUFA10", "NDUFA11", "NDUFA13", "NDUFA4", "NDUFA5", "NDUFA7", "NDUFA8", "NDUFA9", "NDUFAF2", "NDUFB10", "NDUFB3", "NDUFB4", "NDUFB5", "NDUFB6", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS6", "NDUFS7", "NDUFS8", "NDUFV1", "NDUFV2", "NECAP2", "NEDD4L", "NENF", "NF1", "NFKBIL1", "NFS1", "NFXL1", "NHP2", "NIP7", "NIPBL", "NISCH", "NIT2", "NKRF", "NKTR", "NLN", "NLRX1", "NME1", "NME2", "NMT1", "NNT", "NOC4L", "NOL6", "NOL9", "NOM1", "NONO", "NOP14", "NOP56", "NOP58", "NOP9", "NPEPPS", "NPM1", "NRBP1", "NRDC", "NSDHL", "NSF", "NSUN2", "NT5C2", "NT5C3A", "NT5C3B", "NT5DC1", "NT5DC2", "NTHL1", "NTMT1", "NTPCR", "NUCB1", "NUCB2", "NUDC", "NUDCD2", "NUDCD3", "NUDT1", "NUDT21", "NUDT5", "NUF2", "NUMA1", "NUP107", "NUP153", "NUP155", "NUP160", "NUP210", "NUP214", "NUP37", "NUP50", "NUP54", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NXF1", "NXN", "OAT", "OCIAD1", "OCLN", "OCRL", "OGDH", "OGFOD3", "OGT", "OLA1", "OPA1", "ORC2", "ORC3", "ORC5", "OSGEP", "OTUB1", "OXA1L", "P3H1", "P3H4", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPN1", "PACSIN2", "PAFAH1B2", "PAFAH1B3", "PAK1IP1", "PAK2", "PALD1", "PALLD", "PANK4", "PAPOLA", "PARG", "PARN", "PARP1", "PARP2", "PATL1", "PBK", "PBRM1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCMT1", "PCNA", "PCYOX1", "PDCD11", "PDCD5", "PDCD6", "PDCD6IP", "PDCL3", "PDE12", "PDHA1", "PDHB", "PDHX", "PDIA3", "PDIA4", "PDIA6", "PDK1", "PDK3", "PDLIM1", "PDLIM5", "PDP1", "PDS5A", "PDS5B", "PDZD8", "PEBP1", "PECR", "PELO", "PEPD", "PES1", "PEX14", "PEX19", "PFDN2", "PFDN5", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGM3", "PGP", "PGRMC1", "PGRMC2", "PHF10", "PHF3", "PHF6", "PHGDH", "PHKA1", "PHKB", "PI4K2A", "PI4KA", "PI4KB", "PICALM", "PIK3C2A", "PIK3R2", "PIK3R4", "PIN1", "PINX1", "PIP4K2C", "PIR", "PISD", "PITHD1", "PITPNA", "PITPNB", "PITRM1", "PKM", "PKMYT1", "PKN1", "PKN2", "PLA2G15", "PLAA", "PLBD2", "PLCG1", "PLD3", "PLD6", "PLEC", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLS3", "PM20D2", "PMPCA", "PMPCB", "PMVK", "PNP", "PNPLA6", "PNPLA8", "PNPT1", "POFUT1", "POGZ", "POLA1", "POLA2", "POLD1", "POLD2", "POLDIP3", "POLE", "POLE2", "POLG", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2A", "POLR2B", "POLR2C", "POLR2D", "POLR2E", "POLR2G", "POLR2L", "POLR3A", "POLR3B", "POLR3C", "POLRMT", "POR", "PPA1", "PPA2", "PPAN", "PPAT", "PPCDC", "PPIB", "PPIC", "PPID", "PPIE", "PPIF", "PPIG", "PPIH", "PPIL4", "PPM1G", "PPME1", "PPOX", "PPP1CA", "PPP1CB", "PPP1R10", "PPP1R7", "PPP1R8", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP2R5E", "PPP3CA", "PPP4R1", "PPP4R3A", "PPP5C", "PPP6C", "PPP6R3", "PPT1", "PPWD1", "PQBP1", "PRAF2", "PRC1", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PREP", "PREPL", "PRIM1", "PRIM2", "PRKAA1", "PRKAA2", "PRKACA", "PRKAG1", "PRKAR1A", "PRKAR2A", "PRKCB", "PRKCSH", "PRKDC", "PRMT1", "PRMT3", "PRMT5", "PRMT9", "PRPF19", "PRPF3", "PRPF31", "PRPF4", "PRPF4B", "PRPF6", "PRPF8", "PRPS2", "PRPSAP1", "PRPSAP2", "PRRC2A", "PRRC2B", "PRRC2C", "PSAP", "PSAT1", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD7", "PSMD8", "PSMG1", "PSMG2", "PSMG3", "PSPC1", "PTCD1", "PTDSS1", "PTDSS2", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK7", "PTPA", "PTPN1", "PTPN11", "PTPN23", "PTPRF", "PUF60", "PURA", "PUS1", "PWP1", "PXMP2", "PXN", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QDPR", "QKI", "QRSL1", "QSOX2", "QTRT2", "RAB3GAP1", "RAB3GAP2", "RABGAP1", "RABGGTA", "RABL6", "RAC1", "RACGAP1", "RAD18", "RAD23A", "RAD23B", "RAE1", "RALA", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP6", "RANBP9", "RANGAP1", "RAPGEF2", "RARS", "RARS2", "RAVER1", "RBBP6", "RBM12", "RBM12B", "RBM14", "RBM17", "RBM19", "RBM22", "RBM26", "RBM27", "RBM34", "RBM4", "RBM47", "RBPJ", "RCL1", "RCN1", "RCN2", "RDH11", "RDH13", "RDH14", "RDX", "RECQL", "REEP4", "REEP5", "REXO4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RHBDD2", "RHEB", "RHOG", "RHOT1", "RHOT2", "RIDA", "RIF1", "RIPK1", "RNASEH2A", "RNF2", "RNMT", "RNPS1", "ROCK1", "ROCK2", "RP2", "RPA1", "RPF1", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPN1", "RPN2", "RPP30", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS26", "RPS28", "RPS29", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RPUSD3", "RRAS2", "RRBP1", "RRM1", "RRM2", "RRS1", "RSF1", "RSL1D1", "RSL24D1", "RSU1", "RTCA", "RTN4IP1", "S100A11", "S100A13", "SAAL1", "SACM1L", "SAE1", "SALL2", "SAMHD1", "SAP130", "SAP18", "SAP30BP", "SARM1", "SARS", "SARS2", "SART1", "SART3", "SBDS", "SCAF1", "SCAF4", "SCAMP1", "SCAMP2", "SCAMP3", "SCAMP4", "SCARB1", "SCARB2", "SCFD1", "SCFD2", "SCML2", "SCO1", "SCO2", "SCP2", "SCPEP1", "SCRIB", "SCYL1", "SDF4", "SDHA", "SDHB", "SDHC", "SDR39U1", "SEC11A", "SEC23A", "SEC23B", "SEC23IP", "SEC24A", "SEC24B", "SEC24C", "SEC31A", "SEC61A1", "SEC61B", "SEC63", "SEH1L", "SENP3", "SEPT11", "SEPT2", "SEPT7", "SEPT9", "SERBP1", "SERPINB6", "SERPINH1", "SET", "SETD1A", "SETD2", "SETD3", "SETDB1", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFSWAP", "SFXN1", "SFXN2", "SFXN4", "SHMT1", "SHMT2", "SIGMAR1", "SIN3A", "SKIV2L", "SKIV2L2", "SKP1", "SLC12A2", "SLC12A9", "SLC16A1", "SLC19A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A16", "SLC25A19", "SLC25A20", "SLC25A21", "SLC25A24", "SLC25A25", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A33", "SLC25A4", "SLC25A44", "SLC25A5", "SLC25A6", "SLC27A4", "SLC33A1", "SLC35B2", "SLC39A14", "SLC4A1AP", "SLC4A2", "SLC5A6", "SLC7A1", "SLMAP", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMC6", "SMG1", "SMG5", "SMN1*", "SMNDC1", "SMPD4", "SNRNP200", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNU13", "SNW1", "SNX1", "SNX17", "SNX19", "SNX2", "SNX27", "SNX5", "SNX6", "SNX9", "SOAT1", "SOD2", "SON", "SORD", "SORT1", "SPAG9", "SPCS2", "SPCS3", "SPDL1", "SPEN", "SPNS1", "SPOUT1", "SPPL2A", "SPR", "SPTLC1", "SPTLC2", "SQLE", "SREK1", "SRI", "SRM", "SRP14", "SRP54", "SRP68", "SRP9", "SRPK1", "SRPK2", "SRPRA", "SRPRB", "SRRM1", "SRSF1", "SRSF10", "SRSF11", "SRSF3", "SRSF4", "SRSF5", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSR1", "STAG1", "STAG2", "STAM", "STAM2", "STAT1", "STAT3", "STK3", "STK4", "STOM", "STOML2", "STRAP", "STRBP", "STT3A", "STT3B", "STUB1", "STX10", "STX12", "STX16", "STX18", "STX4", "STX7", "STX8", "STXBP2", "STXBP3", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGP2", "SUN1", "SUN2", "SUPT16H", "SUPT3H", "SUPT6H", "SUPV3L1", "SURF6", "SUZ12", "SYNCRIP", "SYNGR2", "SYNJ2BP", "SYS1", "TAB1", "TAF15", "TAF6", "TAGLN2", "TALDO1", "TAP1", "TAP2", "TARBP1", "TARS", "TARS2", "TARSL2", "TBC1D13", "TBC1D15", "TBC1D4", "TBC1D9B", "TBCA", "TBCB", "TBCD", "TBCE", "TBL3", "TCEA1", "TCERG1", "TCOF1", "TCP1", "TCP11L1", "TDRKH", "TECR", "TERF2IP", "TES", "TFB1M", "TFCP2", "TFG", "TFIP11", "TFRC", "TGOLN2", "THADA", "THOC1", "THOC2", "THOC3", "THOP1", "THRAP3", "TIA1", "TIAL1", "TIGAR", "TIMM10B", "TIMM17B", "TIMM23", "TIMM44", "TJP1", "TJP2", "TK1", "TKT", "TLE3", "TLK2", "TM9SF2", "TM9SF3", "TM9SF4", "TMED10", "TMED2", "TMED7", "TMED9", "TMEM115", "TMEM259", 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0.0007105677029561 +Calmodulin 6 14 2.004946888977281 0.0449687252340533 5.330097087378641 14.50728155339806 1.3338669185027796 0.2094989649985028 2.1356354617596836 1.8597539737980884 1.176586593960994 0.2465515447823433 0.0090332289343176 0.1430638950507344 0.0034893000144238 0.0009276346440678 0.0007105677029561 diff --git a/pharos_dto/metrics.json b/pharos_dto/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..d04e8d438e73f8249d71a4ad7e8cc56c11d7411b --- /dev/null +++ b/pharos_dto/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3221, + "annotations_size": 2037, + "title": "Average number of proteins per term", + "value": 3.141384388807069 +} \ No newline at end of file diff --git a/pharos_dto/paths.json b/pharos_dto/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..f94e513faf265995a7334fc96c48a86967d6a07e --- /dev/null +++ b/pharos_dto/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/pharos_dto/fragment/C201/C201_val_log2fc"} \ No newline at end of file diff --git a/pharos_dto/result.tsv b/pharos_dto/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..c6a0e9afe224e7669ae2cd2844a9a1e63e8aa91c --- /dev/null +++ b/pharos_dto/result.tsv @@ -0,0 +1,66 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +SLC25 family of mitochondrial transporters 0.7950682684119263 3.713768788843645 0.0002041953667 0.3403121001827522 0.1567155742259351 23 Q9BSK2,Q9HC21,Q6NUK1,Q96H78,P12236,Q9UJS0,O75746,Q70HW3,Q9BQT8,Q9UBX3,Q9H2D1,Q9NZJ7,P16260,P53007,P12235,Q9Y6C9,Q6KCM7,Q9Y619 18 +SLC superfamily of solute carriers 0.6647880885993948 3.4335569570541833 0.0005957170299561 0.7029447639982694 0.1567155742259351 45 Q9BSK2,Q9HC21,O00400,P05141,Q9H2D1,P53007,Q9Y6C9,Q6NUK1,Q96H78,Q8TB61,Q9H2V7,Q6KCM7,O95202,Q70HW3,Q9BQT8,Q15043,P30825,P12236,Q9UJS0,O75746,Q9UBX3,P04920,Q9NZJ7,Q7L0J3,P16260,P12235,Q9Y619 27 +Glycosyltransferase 0.7176176749278399 2.828078197510487 0.0046828366387774 0.9999296017990668 0.1567155742259351 17 Q8N4A0,Q16739,Q8N6G5,Q9BT22,P35573,Q8N128,Q10472,P46977 8 +Mitochondrial nucleotide transporter subfamily 0.809345794392538 2.801398931912038 0.0050881576295875 0.9999692934686748 0.1567155742259351 11 Q9BSK2,P12236,Q6NUK1,Q9HC21,Q70HW3,P05141,Q9H2D1,P16260,P12235,Q6KCM7 10 +P-type ATPases 0.8111971922428791 2.630517096406536 0.0085255081379578 0.9999999733616116 0.1567155742259351 9 P98194,P23634,P20020,P05023,P16615,P35670,Q04656 7 +Receptor 0.5999071397005995 2.593047546937997 0.0095129617915159 0.9999999965005588 0.1567155742259351 32 Q13641,Q9NR77,P57105,O75787,P39210,O75381,Q6NTF9,Q14108,Q567V2,Q9NUJ3,Q9GZP9,Q8WTV0 12 +Oxidase 0.6492972949928397 2.4719260383763295 0.0134387316423196 0.9999999999989267 0.1567155742259351 18 P20674,P14406,O14548,O75880,O43819,Q15800,O15254,O43169 8 +Membrane trafficking regulatory protein 0.6098622602643667 2.3346567909585874 0.0195613572160813 1.0 0.1569760437197719 20 P24390,P11279,O43760,P13473 4 +SNARE protein 0.7417624836189386 2.285688992118348 0.022272459702094 1.0 0.1569760437197719 9 O15400,Q9P2W9,O95249,O60499 4 +Calcium-binding protein 0.6218024227505294 2.246224433637488 0.0246896359520931 1.0 0.1586543554616661 17 Q14257,P41208,P43307,Q02818,P80303 5 +Transporter 0.5483840317623826 2.206326525663264 0.0273611454136617 1.0 0.1590508928136099 198 Q86Y82,Q9BSK2,P06576,O00400,Q9HC21,Q15363,P56385,P05141,Q9H2D1,Q9Y296,Q9P2W9,P20020,P55011,Q8N2H4,P53007,P05023,Q9H6H4,Q9Y6C9,P16615,Q03519,P98194,Q6NUK1,Q9NRK6,Q96H78,P17900,P24390,P24539,Q8TB61,Q9C0E2,Q12768,Q96ES6,O95249,O96008,Q9H2V7,O43493,Q9Y5J6,P35670,Q6KCM7,O95202,O60749,Q04656,P52292,P11279,O43760,O60499,Q15388,Q70HW3,Q9BQT8,Q8TEX9,O15400,Q03518,Q15070,P30825,Q15043,Q9HD45,Q8NFH4,Q9BVK6,P12236,Q93050,Q9UJS0,Q00765,P49755,Q9UBX3,P51572,O75746,Q9NUT2,Q9NZJ7,Q9NP58,Q7L0J3,P04920,Q9Y487,P13473,P16260,P12235,Q9Y619,O00203 76 +Metalloprotease 0.5251649655127877 2.159588247125305 0.0308045590644654 1.0 0.1627723122429793 39 Q6P179,P55786,Q99797,Q7Z2K6,Q10713,P22695,Q96TA2,Q92905,Q5JRX3,Q9UIQ6,P42892,Q8IYS1,O43847,O75844,Q9NZ08,Q7L5N1,P52888,O00303,P53582 19 +Ion channel 0.7436872982589409 2.1379205302160136 0.0325231936754133 1.0 0.1648003619821318 8 P0CG08,Q9C0H2,Q4KMQ2,Q96S66,P51798,P51790 6 +Acyltransferase 0.6772960347199904 2.108836997250096 0.0349586539157358 1.0 0.1697681136525921 11 Q8NF37,Q92696,P49354,Q9UJ14 4 +Signaling 0.5907152715495598 2.0980810195951904 0.035897988931544 1.0 0.1697681136525921 18 Q5JRA6,P43490,Q96PC5,Q7Z4V5,Q07820,O00264,Q8IZ81,O15173 8 +Mitochondrial amino acid transporter subfamily 0.8290681884376978 2.072293900274421 0.0382380409306304 1.0 0.1723360508701577 5 Q96H78,Q9UJS0,Q9Y619 3 +F-type ATPase 0.7479087696145037 2.0127409309618254 0.04414189096415 1.0 0.1801129938646931 7 P06576,P24539 2 +Intracellular calcium-sensing protein 0.6136816567252825 2.0049468889772815 0.0449687252340533 1.0 0.181030223916535 14 Q14257,P41208,O43852,Q02818,P80303,Q9BRK5 6 +Calmodulin 0.6136816567252825 2.0049468889772815 0.0449687252340533 1.0 0.181030223916535 14 Q14257,P41208,O43852,Q02818,P80303,Q9BRK5 6 +ABCB subfamily 0.7293092719352926 1.9234343706735055 0.0544255212897191 1.0 0.1978095376527155 7 Q03519,Q9NRK6,Q03518,Q9NP58,O75027,Q9NUT2 6 +Phosphatase inhibitor 0.7492169943509261 1.8840375048002809 0.0595599025610584 1.0 0.2070367261380138 6 Q01105,Q99733 2 +F-type and V-type ATPases 0.5735607575363451 1.8496798473257203 0.0643597067826176 1.0 0.2145674676206089 15 P06576,Q9Y487,Q93050,P24539 4 +Heterotrimeric G-protein 0.6697545430198805 1.766185004042399 0.0773648160597557 1.0 0.2341636408822028 8 P50148,P63218,Q8NHH9,P04899 4 +Reductase 0.5511321262938937 1.746609749179568 0.0807050549359789 1.0 0.2382553578327377 16 P31350,Q15392,O95168,Q9UDW1,Q9H7Z7,Q14739 6 +Ca2+-ATPases 0.8281007149518073 1.6258556230634034 0.1039803723382397 1.0 0.2720177430651915 4 P20020,P98194,P16615 3 +Mitochondrial di- and tri-carboxylic acid transporter subfamily 0.8054052298673152 1.5325149532011724 0.1253954104816981 1.0 0.3015707805799516 4 Q9BQT8,Q9UBX3 2 +Chloride channel family 0.9316557937247584 1.4831856995812944 0.1380250795744433 1.0 0.3206981703816301 2 P51798 1 +Cu+-ATPases 0.9015222118670334 1.3598263227276226 0.1738848904852505 1.0 0.3708999275002923 2 P35670 1 +Phosphatase modulator 0.5916723766702885 1.358664826238012 0.174252822787158 1.0 0.3708999275002923 8 Q01105,Q99733 2 +Miscellaneous SLC25 mitochondrial transporters 0.8732525629077283 1.244540445367799 0.2133007234192918 1.0 0.416580607483315 2 Q9NZJ7 1 +Aspartic protease 0.7336027354678039 1.235012598775903 0.2168258152864361 1.0 0.4190457170194216 4 Q8TCT8,Q8TCT9,Q5BJF2 3 +Oxygenase 0.641307827849825 1.2331492002752165 0.217520104175207 1.0 0.4195913373152431 5 Q16850 1 +Extracellular structure 0.5585696734912529 1.182447660599491 0.2370281215327221 1.0 0.441173907869632 8 Q92791 1 +Decarboxylase 0.7131597680280377 1.1501694534551143 0.2500740848500111 1.0 0.4573960641528782 4 P48163 1 +Oxidoreductase 0.3775856462594947 1.0252998384890906 0.3052217319895316 1.0 0.510876473346488 115 Q9P0J0,P20674,Q8IZ83,Q9H9P8,Q8N4Q0,Q15392,Q9UDW1,P09622,O43819,Q15800,P03886,O43169,Q9NZ01,O43175,P14406,O14548,P31350,Q96CU9,P00403,Q9H7Z7,Q13423,Q16850,Q9UBM7,O95831,O95168,Q14534,Q9Y6M9,Q8TED1,P21912,Q14739,O75880,P51970,O15254 33 +Na+/K+-ATPases 0.7971772163023694 0.9907669640814412 0.321799384101489 1.0 0.5269335574073417 3 P05023 1 +V-type ATPase 0.521804188589855 0.9857305203246972 0.3242653684643677 1.0 0.5275787184999337 8 Q93050 1 +Growth factor 0.5600804912169454 0.9770407557100568 0.328548975834289 1.0 0.5319986198525013 6 Q96PC5,Q5JRA6 2 +Tubulin 0.5480559875583171 0.918693609223736 0.358255853478598 1.0 0.5644324706987376 6 Q13509,P07437,P04350,Q9BVA1,Q13885 5 +SLC35 family of nucleotide sugar transporters 0.7642124883504053 0.8128125148404888 0.4163255591553225 1.0 0.6149783640314662 2 Q8TB61 1 +SLC12 family of cation-coupled chloride transporters 0.7604846225535835 0.7986985477140612 0.4244652290957045 1.0 0.6215862558448034 2 P55011 1 +Phospholipase 0.6271044292260932 0.7979488177619288 0.4249001922677409 1.0 0.6215862558448034 4 Q8N2A8 1 +G-protein 0.3743849051309204 0.7838497565353402 0.4331282741216704 1.0 0.6297518161212295 32 O60313,Q8IXI1,Q15382,P84095,Q8NHH9,P50148,Q9NTK5,P04899,P63096,P50570,Q15019,P63218,Q96P70 13 +ATP-binding cassette transporter family 0.4140323880298475 0.5034339640003401 0.6146591974910227 1.0 0.7606687638452085 9 Q03519,Q9NRK6,P28288,Q03518,Q9NP58,Q9NUT2 6 +AMPK subfamily 0.6688412550481487 0.4770466569105189 0.6333288982507417 1.0 0.7683686514215371 2 Q13131 1 +Nucleotide phosphatase 0.4181753793326337 0.4463642638056629 0.655334142360293 1.0 0.7779228717878303 8 O95140,Q8IWA4,O43681 3 +Phosphatase 0.3318848590655402 0.4217873483261712 0.6731802411024215 1.0 0.7867287155052396 31 P11117,Q8IWA4,Q86YN1,Q9NX62,Q9NPH0 5 +CAMKL family 0.6208825357364841 0.3840836157611622 0.7009164746335617 1.0 0.8030750906931232 3 P54646,Q13131 2 +Unclassified protein 0.339122589353124 0.3063647761417985 0.7593269243170708 1.0 0.8236149865995065 15 Q9BRR6 1 +Damaged DNA-binding protein 0.426990028003248 0.3029201906370972 0.7619506839322088 1.0 0.8248358080633632 5 P54725 1 +Methyltransferase 0.3359906737471533 0.2163624181463484 0.8287052584184442 1.0 0.8625818147155702 13 P21964,Q9BV86 2 +CAMK group 0.3876445387556022 0.207614147494084 0.835530256956643 1.0 0.8658190218047972 6 O75962,Q13131,O14936 3 +Small GTPase 0.3006267926462279 0.167147933204213 0.8672536512405207 1.0 0.8841820258142846 22 O60313,Q8IXI1,Q15382,P84095 4 +Ubiquitin-protein ligase 0.3086726645714216 0.156365544561563 0.8757448945241655 1.0 0.8906102596833376 18 Q96PU5,Q9H000,Q9NX47,P38398,Q13616 5 +Protease inhibitor 0.3368800879460567 0.1475417805903581 0.8827044044120078 1.0 0.8972399559816667 10 P27105 1 +TKL group 0.5082323703013247 0.1124738568023225 0.9104476974445768 1.0 0.9236970527327244 2 Q13546 1 +PDHK family 0.5015537600994503 0.1123489556247297 0.9105467265033436 1.0 0.9236970527327244 3 O14874,Q15120 2 +AGC group 0.3276874931373316 0.1074677634213682 0.9144178982450344 1.0 0.9262403076703803 10 O14578,P51812 2 +Protease 0.2948345067772484 0.0874908913162165 0.9302813253452182 1.0 0.9413726079126724 111 Q6P179,Q96RU2,P55786,Q99797,O14773,Q7Z2K6,Q10713,P10619,P22695,Q96TA2,Q92905,Q92643,Q5JRX3,P53634,Q9UIQ6,P42892,Q8NHP8,Q13510,Q86UT6,Q8IYS1,O43847,P14735,O75844,P67812,Q9NZ08,P42785,Q8TCT8,Q5BJF2,Q8TCT9,Q8N2K0,Q7L5N1,Q9HB40,P52888,O00303,Q9Y6M1,Q9H3G5,P53582 37 +Epimerase/racemase 0.3203246303847999 0.0767816212580978 0.9387972716822676 1.0 0.94810611919523 10 P40939 1 +Lyase 0.2905942066452084 0.0705957238901872 0.9437195137645956 1.0 0.9521330606926602 20 Q96KA5,P48163,O96005,P22830 4 +Transferase 0.3156288956757458 0.0640754062434113 0.9489101845697308 1.0 0.956422585833024 137 Q8N6G5,Q9BT22,Q96N66,O15269,O15127,Q92696,Q8N4A0,Q14168,Q9UJ14,P50416,Q9BV86,P48651,Q9BVG9,Q16739,P35573,P49354,P23786,Q99735,Q8NCH0,Q8N128,O43252,Q10472,Q13126,Q6UX53,P46977,P21964,Q8NF37 27 +Lysine-specific demethylase 0.4066480273376767 0.0377074691939469 0.9699209206780834 1.0 0.9761374342069216 2 Q8NB78 1 +Carbohydrate kinase 0.4047840944392536 0.0371229254386091 0.9703869927682948 1.0 0.9761374342069216 2 P19367 1 +MST subfamily 0.3072382727555196 0.0245023805033133 0.98045188491912 1.0 0.9857751676111784 2 Q13043 1 diff --git a/pharos_dto/selections.json b/pharos_dto/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..81b4008dd2265aa3c8cac727d386b8a974ff518d --- /dev/null +++ b/pharos_dto/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase", "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1", "10 kDa heat shock protein, mitochondrial", "116 kDa U5 small nuclear ribonucleoprotein component", "14-3-3 protein beta/alpha", "14-3-3 protein epsilon", "14-3-3 protein eta", "14-3-3 protein gamma", "14-3-3 protein theta", "14-3-3 protein zeta/delta", "2',3'-cyclic-nucleotide 3'-phosphodiesterase", "2',5'-phosphodiesterase 12", "2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial", "2-hydroxyacyl-CoA lyase 1", "26S proteasome non-ATPase regulatory subunit 1", "26S proteasome non-ATPase regulatory subunit 12", "26S proteasome non-ATPase regulatory subunit 13", "26S proteasome non-ATPase regulatory subunit 14", "26S proteasome non-ATPase regulatory subunit 2", "26S proteasome non-ATPase regulatory subunit 3", "26S proteasome non-ATPase regulatory subunit 4", "26S proteasome non-ATPase regulatory subunit 7", "26S proteasome non-ATPase regulatory subunit 8", "26S proteasome regulatory subunit 10B", "26S proteasome regulatory subunit 4", "26S proteasome regulatory subunit 6A", "26S proteasome regulatory subunit 6B", "26S proteasome regulatory subunit 7", "26S proteasome regulatory subunit 8", "28S ribosomal protein S11, mitochondrial", "28S ribosomal protein S16, mitochondrial", "28S ribosomal protein S27, mitochondrial", "28S ribosomal protein S29, mitochondrial", "28S ribosomal protein S35, mitochondrial", "28S ribosomal protein S5, mitochondrial", "28S ribosomal protein S7, mitochondrial", "3'(2'),5'-bisphosphate nucleotidase 1", "3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase", "3-hydroxyacyl-CoA dehydrogenase type-2", "3-hydroxyisobutyrate dehydrogenase, mitochondrial", "3-hydroxyisobutyryl-CoA hydrolase, mitochondrial", "3-ketoacyl-CoA thiolase, mitochondrial", "3-ketoacyl-CoA thiolase, peroxisomal", "3-mercaptopyruvate sulfurtransferase", "39S ribosomal protein L1, mitochondrial", "39S ribosomal protein L11, mitochondrial", "39S ribosomal protein L12, mitochondrial", "39S ribosomal protein L14, mitochondrial", "39S ribosomal protein L17, mitochondrial", "39S ribosomal protein L19, mitochondrial", "39S ribosomal protein L2, mitochondrial", "39S ribosomal protein L20, mitochondrial", "39S ribosomal protein L21, mitochondrial", "39S ribosomal protein L22, mitochondrial", "39S ribosomal protein L24, mitochondrial", "39S ribosomal protein L38, mitochondrial", "39S ribosomal protein L39, mitochondrial", "39S ribosomal protein L41, mitochondrial", "39S ribosomal protein L43, mitochondrial", "39S ribosomal protein L44, mitochondrial", "39S ribosomal protein L47, mitochondrial", "39S ribosomal protein L48, mitochondrial", "39S ribosomal protein L49, mitochondrial", "39S ribosomal protein L9, mitochondrial", "39S ribosomal protein S18a, mitochondrial", "4-trimethylaminobutyraldehyde dehydrogenase", "40S ribosomal protein S10", "40S ribosomal protein S11", "40S ribosomal protein S12", "40S ribosomal protein S13", "40S ribosomal protein S14", "40S ribosomal protein S15", "40S ribosomal protein S15a", "40S ribosomal protein S17", "40S ribosomal protein S18", "40S ribosomal protein S19", "40S ribosomal protein S2", "40S ribosomal protein S20", "40S ribosomal protein S21", "40S ribosomal protein S23", "40S ribosomal protein S24", "40S ribosomal protein S26", "40S ribosomal protein S28", "40S ribosomal protein S3", "40S ribosomal protein S3a", "40S ribosomal protein S4, X isoform", "40S ribosomal protein S5", "40S ribosomal protein S6", "40S ribosomal protein S7", "40S ribosomal protein S8", "40S ribosomal protein S9", "40S ribosomal protein SA", "45 kDa calcium-binding protein", "4F2 cell-surface antigen heavy chain", "5'-AMP-activated protein kinase catalytic subunit alpha-1", "5'-AMP-activated protein kinase catalytic subunit alpha-2", "5'-AMP-activated protein kinase subunit gamma-1", "5'-nucleotidase domain-containing protein 1", "5'-nucleotidase domain-containing protein 2", "5-formyltetrahydrofolate cyclo-ligase", "55 kDa erythrocyte membrane protein", "6-phosphogluconate dehydrogenase, decarboxylating", "6-phosphogluconolactonase", "60 kDa SS-A/Ro ribonucleoprotein", "60S ribosomal protein L10", "60S ribosomal protein L10a", "60S ribosomal protein L11", "60S ribosomal protein L12", "60S ribosomal protein L13", "60S ribosomal protein L13a", "60S ribosomal protein L14", "60S ribosomal protein L15", "60S ribosomal protein L18", "60S ribosomal protein L19", "60S ribosomal protein L21", "60S ribosomal protein L22", "60S ribosomal protein L23", "60S ribosomal protein L23a", "60S ribosomal protein L24", "60S ribosomal protein L26", "60S ribosomal protein L27", "60S ribosomal protein L27a", "60S ribosomal protein L28", "60S ribosomal protein L29", "60S ribosomal protein L3", "60S ribosomal protein L30", "60S ribosomal protein L31", "60S ribosomal protein L32", "60S ribosomal protein L35", "60S ribosomal protein L35a", "60S ribosomal protein L36", "60S ribosomal protein L36a", "60S ribosomal protein L37", "60S ribosomal protein L38", "60S ribosomal protein L5", "60S ribosomal protein L6", "60S ribosomal protein L7", "60S ribosomal protein L7-like 1", "60S ribosomal protein L7a", "60S ribosomal protein L8", "60S ribosomal protein L9", "7,8-dihydro-8-oxoguanine triphosphatase", "7-dehydrocholesterol reductase", "7-methylguanosine phosphate-specific 5'-nucleotidase", "A-kinase anchor protein 1, mitochondrial", "ABCB subfamily", "ABCC subfamily", "ABCD subfamily of peroxisomal ABC transporters", "ADP-dependent glucokinase", "ADP-sugar pyrophosphatase", "ADP/ATP translocase 1", "ADP/ATP translocase 2", "ADP/ATP translocase 3", "AFG3-like protein 2", "AGC group", "AH receptor-interacting protein", "AK1 subfamily", "AK2 subfamily", "AK3 subfamily", "AKT family", "AMPK subfamily", "AP-1 complex subunit beta-1", "AP-1 complex subunit gamma-1", "AP-1 complex subunit mu-1", "AP-1 complex subunit sigma-1A", "AP-2 complex subunit alpha-1", "AP-2 complex subunit alpha-2", "AP-2 complex subunit beta", "AP-2 complex subunit mu", "AP-2 complex subunit sigma", "AP-3 complex subunit beta-1", "AP-3 complex subunit delta-1", "AP-3 complex subunit mu-1", "AT-rich interactive domain-containing protein 3B", "ATP synthase F(0) complex subunit B1, mitochondrial", "ATP synthase mitochondrial F1 complex assembly factor 1", "ATP synthase subunit alpha, mitochondrial", "ATP synthase subunit beta, mitochondrial", "ATP synthase subunit d, mitochondrial", "ATP synthase subunit e, mitochondrial", "ATP synthase subunit f, mitochondrial", "ATP synthase subunit gamma, mitochondrial", "ATP-binding cassette sub-family B member 10, mitochondrial", "ATP-binding cassette sub-family B member 6, mitochondrial", "ATP-binding cassette sub-family B member 7, mitochondrial", "ATP-binding cassette sub-family B member 8, mitochondrial", "ATP-binding cassette sub-family D member 3", "ATP-binding cassette sub-family F member 1", "ATP-binding cassette sub-family F member 2", "ATP-binding cassette sub-family F member 3", "ATP-binding cassette transporter family", "ATP-citrate synthase", "ATP-dependent 6-phosphofructokinase, muscle type", "ATP-dependent 6-phosphofructokinase, platelet type", "ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial", "ATP-dependent DNA helicase Q1", "ATP-dependent PFK group I subfamily", "ATP-dependent RNA helicase A", "ATP-dependent RNA helicase DHX29", "ATP-dependent RNA helicase DHX8", "ATP-dependent zinc metalloprotease YME1L1", "ATPase ASNA1", "ATPase WRNIP1", "ATPase family AAA domain-containing protein 2", "ATPase family AAA domain-containing protein 3A", "ATPase family AAA domain-containing protein 3B", "ATPase inhibitor, mitochondrial", "AUR family", "Acetolactate synthase-like protein", "Acetyl-CoA acetyltransferase, cytosolic", "Acetyl-CoA acetyltransferase, mitochondrial", "Acetyl-coenzyme A transporter 1", "Acetyltransferase", "Acid ceramidase", "Acidic leucine-rich nuclear phosphoprotein 32 family member A", "Acidic leucine-rich nuclear phosphoprotein 32 family member B", "Acidic leucine-rich nuclear phosphoprotein 32 family member E", "Aconitate hydratase, mitochondrial", "Actin and actin related protein", "Actin binding motor protein", "Actin family cytoskeletal protein", "Actin-like protein 6A", "Actin-related protein 2", "Actin-related protein 2/3 complex subunit 1A", "Actin-related protein 2/3 complex subunit 3", "Actin-related protein 2/3 complex subunit 4", "Actin-related protein 3", "Actin-related protein 8", "Activating signal cointegrator 1", "Acyl-CoA dehydrogenase family member 11", "Acyl-CoA dehydrogenase family member 9, mitochondrial", "Acyl-CoA synthetase family member 3, mitochondrial", "Acyl-CoA-binding domain-containing protein 5", "Acyl-coenzyme A thioesterase 8", "Acyl-coenzyme A thioesterase 9, mitochondrial", "Acylamino-acid-releasing enzyme", "Acylpyruvase FAHD1, mitochondrial", "Acyltransferase", "Adenosine 3'-phospho 5'-phosphosulfate transporter 1", "Adenosine deaminase", "Adenosine kinase", "Adenosylhomocysteinase", "Adenylate kinase 2, mitochondrial", "Adenylate kinase 4, mitochondrial", "Adenylate kinase family", "Adenylate kinase isoenzyme 1", "Adenylate kinase isoenzyme 6", "Adenylosuccinate lyase", "Adenylosuccinate synthetase isozyme 2", "Adenylyl cyclase-associated protein 1", "Afadin", "Aflatoxin B1 aldehyde reductase member 2", "Alanine aminotransferase 2", "Alanine--tRNA ligase, cytoplasmic", "Alanine--tRNA ligase, mitochondrial", "Alanine/serine/cysteine transporter subfamily", "Alcohol dehydrogenase [NADP(+)]", "Alcohol dehydrogenase class-3", "Aldehyde dehydrogenase X, mitochondrial", "Aldehyde dehydrogenase family 16 member A1", "Aldehyde dehydrogenase, mitochondrial", "Aldose 1-epimerase", "Aldose reductase", "Alpha-adducin", "Alpha-aminoadipic semialdehyde dehydrogenase", "Alpha-centractin", "Alpha-enolase", "Alpha-globin transcription factor CP2", "Alpha-soluble NSF attachment protein", "Alpha-taxilin", "Amidophosphoribosyltransferase", "Aminoacyl tRNA synthase complex-interacting multifunctional protein 1", "Aminoacyl-tRNA synthetase", "Amyloid-beta A4 protein", "Anaphase-promoting complex subunit 1", "Ancient ubiquitous protein 1", "Anion channel tweety (tweety) family", "Anion exchange protein 2", "Anion exchangers", "Ankyrin repeat and SOCS box protein 6", "Annexin", "Anoctamin-6", "Antibacterial response protein", "Antigen peptide transporter 1", "Antigen peptide transporter 2", "Apoptosis-inducing factor 1, mitochondrial", "Apoptosis-stimulating of p53 protein 2", "Arfaptin-1", "Arfaptin-2", "Arginase-2, mitochondrial", "Armadillo repeat protein deleted in velo-cardio-facial syndrome", "Asparagine synthetase [glutamine-hydrolyzing]", "Asparagine--tRNA ligase, cytoplasmic", "Aspartate--tRNA ligase, cytoplasmic", "Aspartate--tRNA ligase, mitochondrial", "Aspartic protease", "Ataxin-2-like protein", "Atlastin-2", "Atp-dependent 6-phosphofructokinase, liver type", "Atypical SLC22B subfamily", "Atypical group", "Aurora kinase a", "B-cell receptor-associated protein 31", "BTB/POZ domain-containing protein KCTD12", "BUB family", "Basic leucine zipper and W2 domain-containing protein 1", "Basic leucine zipper and W2 domain-containing protein 2", "Bcl-2-associated transcription factor 1", "Beta-centractin", "Beta-galactosidase", "Beta-hexosaminidase subunit alpha", "Beta-hexosaminidase subunit beta", "Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1", "Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase", "Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6", "Bifunctional epoxide hydrolase 2", "Bifunctional glutamate/proline--tRNA ligase", "Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial", "Bifunctional purine biosynthesis protein PURH", "Biliverdin reductase A", "Bleomycin hydrolase", "Brain-specific angiogenesis inhibitor 1-associated protein 2", "Breakpoint cluster region protein", "Breast cancer type 1 susceptibility protein", "Bromodomain", "Bromodomain-containing protein 2", "Bromodomain-containing protein 4", "C-1-tetrahydrofolate synthase, cytoplasmic", "C-Jun-amino-terminal kinase-interacting protein 4", "C-terminal-binding protein 1", "C-terminal-binding protein 2", "C2H2 zinc finger transcription factor", "CAAX prenyl protease 1 homolog", "CAD protein", "CAMK group", "CAMK2 family", "CAMKL family", "CASK family", "CCAAT/enhancer-binding protein zeta", "CCK4 family", "CCR4-NOT transcription complex subunit 1", "CCR4-NOT transcription complex subunit 4", "CD2 antigen cytoplasmic tail-binding protein 2", "CDK family", "CDK1 subfamily", "CDK4 subfamily", "CDK5 subfamily", "CDK9 subfamily", "CDKN2A-interacting protein", "CK1 family", "CK1 group", "CK2 family", "CLIP-associating protein 1", "CLIP-associating protein 2", "CMGC group", "COP9 signalosome complex subunit 3", "COP9 signalosome complex subunit 5", "COP9 signalosome complex subunit 6", "COP9 signalosome complex subunit 8", "CSK family", "CTP synthase 1", "CTP synthase 2", "Ca2+-ATPases", "Cadherin", "Calcium homeostasis endoplasmic reticulum protein", "Calcium uniporter protein, mitochondrial", "Calcium uptake protein 1, mitochondrial", "Calcium-binding mitochondrial carrier protein Aralar1", "Calcium-binding mitochondrial carrier protein Aralar2", "Calcium-binding mitochondrial carrier protein SCaMC-1", "Calcium-binding mitochondrial carrier protein SCaMC-2", "Calcium-binding protein", "Calcium-binding protein 39", "Calcium-dependent chloride channel (ca-clc) family", "Calcium-regulated heat-stable protein 1", "Calcium-transporting ATPase type 2C member 1", "Calcium/calmodulin-dependent protein kinase type ii subunit gamma", "Calcyclin-binding protein", "Calmegin", "Calmodulin", "Calnexin", "Calpain-1 catalytic subunit", "Calpain-2 catalytic subunit", "Calponin-2", "Calponin-3", "Calreticulin", "Calumenin", "Camp-dependent protein kinase catalytic subunit alpha", "Cancer-related nucleoside-triphosphatase", "Caprin-1", "Carbohydrate kinase", "Carbohydrate sulfotransferase 14", "Carnitine O-palmitoyltransferase 1, liver isoform", "Carnitine O-palmitoyltransferase 2, mitochondrial", "Cartilage-associated protein", "Casein kinase II subunit alpha", "Casein kinase II subunit alpha'", "Casein kinase i isoform alpha", "Casein kinase ii subunit beta", "Catechol O-methyltransferase", "Catenin alpha-1", "Catenin delta-1", "Cation-dependent mannose-6-phosphate receptor", "Cation-independent mannose-6-phosphate receptor", "Cell adhesion", "Cell cycle and apoptosis regulator protein 2", "Cell division control protein 42 homolog", "Cell division cycle and apoptosis regulator protein 1", "Cell surface glycoprotein MUC18", "Cell-cell junction", "Cellular structure", "Cellular tumor antigen p53", "Centrin-2", "Centromere/kinetochore protein zw10 homolog", "Centrosomal protein of 170 kDa", "Ceramide glucosyltransferase", "Chaperone", "Chaperonin", "Charged multivesicular body protein 3", "Charged multivesicular body protein 4b", "Charged multivesicular body protein 5", "Charged multivesicular body protein 7", "Chitobiosyldiphosphodolichol beta-mannosyltransferase", "Chloride channel CLIC-like protein 1", "Chloride channel family", "Chloride intracellular channel protein 1", "Choline dehydrogenase, mitochondrial", "Choline kinase alpha", "Choline/ethanolamine kinase family", "Chondroitin sulfate N-acetylgalactosaminyltransferase 2", "Chromatin accessibility complex protein 1", "Chromatin assembly factor 1 subunit A", "Chromatin assembly factor 1 subunit B", "Chromatin target of PRMT1 protein", "Chromatin/chromatin-binding protein", "Chromobox protein homolog 1", "Chromobox protein homolog 2", "Chromobox protein homolog 3", "Chromobox protein homolog 5", "Chromodomain", "Chromosome-associated kinesin KIF4A", "Cilia- and flagella-associated protein 20", "Citrate synthase, mitochondrial", "Citron rho-interacting kinase", "ClC-3/CLCN3 subfamily", "ClC-7/CLCN7 subfamily", "Clathrin heavy chain 1", "Clathrin light chain A", "Clathrin light chain B", "Cleavage and polyadenylation specificity factor subunit 1", "Cleavage and polyadenylation specificity factor subunit 3", "Cleavage and polyadenylation specificity factor subunit 5", "Cleavage and polyadenylation specificity factor subunit 6", "Cleavage and polyadenylation specificity factor subunit 7", "Cleavage stimulation factor subunit 2", "Cleavage stimulation factor subunit 3", "Cleft lip and palate transmembrane protein 1", "Cleft lip and palate transmembrane protein 1-like protein", "Clustered mitochondria protein homolog", "Coactosin-like protein", "Coatomer subunit alpha", "Coatomer subunit beta", "Coatomer subunit beta'", "Coatomer subunit delta", "Coatomer subunit epsilon", "Coatomer subunit gamma-1", "Coatomer subunit gamma-2", "Coatomer subunit zeta-1", "Cohesin subunit SA-1", "Cohesin subunit SA-2", "Coilin", "Cold-inducible RNA-binding protein", "Collagen type IV alpha-3-binding protein", "Collectin-12", "Condensin complex subunit 1", "Condensin-2 complex subunit D3", "Copper-transporting ATPase 1", "Copper-transporting ATPase 2", "Core histone macro-H2A.1", "Core histone macro-H2A.2", "Coronin-1B", "Coronin-1C", "Coronin-7", "Creatine kinase B-type", "Creatine kinase U-type, mitochondrial", "Crooked neck-like protein 1", "Cu+-ATPases", "Cullin-1", "Cullin-2", "Cullin-4A", "Cullin-4B", "Cullin-5", "Cullin-associated NEDD8-dissociated protein 1", "Cullin-associated NEDD8-dissociated protein 2", "Cyclase", "Cyclin-dependent kinase 1", "Cyclin-dependent kinase 12", "Cyclin-dependent kinase 2", "Cyclin-dependent kinase 4", "Cyclin-dependent kinase 6", "Cyclin-dependent kinase 9", "Cyclin-dependent-like kinase 5", "Cyclin-g-associated kinase", "Cystatin-B", "Cysteine and glycine-rich protein 2", "Cysteine and histidine-rich domain-containing protein 1", "Cysteine desulfurase, mitochondrial", "Cysteine protease", "Cysteine protease inhibitor", "Cysteine--tRNA ligase, cytoplasmic", "Cytochrome b-c1 complex subunit 1, mitochondrial", "Cytochrome b-c1 complex subunit 2, mitochondrial", "Cytochrome b-c1 complex subunit 7", "Cytochrome b-c1 complex subunit 9", "Cytochrome b5 type B", "Cytochrome c oxidase subunit 2", "Cytochrome c oxidase subunit 5A, mitochondrial", "Cytochrome c oxidase subunit 5B, mitochondrial", "Cytochrome c oxidase subunit 7A-related protein, mitochondrial", "Cytochrome c oxidase subunit 7A2, mitochondrial", "Cytochrome c oxidase subunit NDUFA4", "Cytochrome c-type heme lyase", "Cytokine", "Cytoplasmic FMR1-interacting protein 1", "Cytoplasmic FMR1-interacting protein 2", "Cytoplasmic aconitate hydratase", "Cytoplasmic dynein 1 heavy chain 1", "Cytoplasmic dynein 1 intermediate chain 2", "Cytoplasmic dynein 1 light intermediate chain 1", "Cytoplasmic dynein 2 heavy chain 1", "Cytoskeleton-associated protein 5", "Cytosol aminopeptidase", "Cytosolic 5'-nucleotidase 3A", "Cytosolic acyl coenzyme A thioester hydrolase", "Cytosolic non-specific dipeptidase", "Cytosolic purine 5'-nucleotidase", "D-3-phosphoglycerate dehydrogenase", "D-dopachrome decarboxylase", "DDB1- and CUL4-associated factor 13", "DDB1- and CUL4-associated factor 8", "DMPK family", "DNA (cytosine-5)-methyltransferase 1", "DNA binding protein", "DNA damage-binding protein 1", "DNA glycosylase", "DNA helicase", "DNA ligase", "DNA ligase 1", "DNA ligase 3", "DNA methyltransferase", "DNA mismatch repair protein Msh2", "DNA mismatch repair protein Msh3", "DNA mismatch repair protein Msh6", "DNA polymerase alpha subunit B", "DNA polymerase delta subunit 2", "DNA polymerase epsilon subunit 2", "DNA polymerase processivity factor", "DNA polymerase subunit gamma-1", "DNA primase small subunit", "DNA replication complex GINS protein PSF2", "DNA replication licensing factor MCM2", "DNA replication licensing factor MCM3", "DNA replication licensing factor MCM4", "DNA replication licensing factor MCM5", "DNA replication licensing factor MCM6", "DNA replication licensing factor MCM7", "DNA topoisomerase", "DNA topoisomerase 1", "DNA-3-methyladenine glycosylase", "DNA-directed DNA polymerase", "DNA-directed RNA polymerase", "DNA-directed RNA polymerase I subunit RPA1", "DNA-directed RNA polymerase I subunit RPA2", "DNA-directed RNA polymerase II subunit RPB1", "DNA-directed RNA polymerase II subunit RPB2", "DNA-directed RNA polymerase II subunit RPB3", "DNA-directed RNA polymerase II subunit RPB4", "DNA-directed RNA polymerase II subunit RPB7", "DNA-directed RNA polymerase III subunit RPC1", "DNA-directed RNA polymerase III subunit RPC2", "DNA-directed RNA polymerase III subunit RPC3", "DNA-directed RNA polymerase, mitochondrial", "DNA-directed RNA polymerases I and III subunit RPAC1", "DNA-directed RNA polymerases I, II, and III subunit RPABC1", "DNA-directed RNA polymerases I, II, and III subunit RPABC5", "DNAPK subfamily", "DYRK family", "Damaged DNA-binding protein", "Deacetylase", "Deaminase", "Death-inducer obliterator 1", "Decarboxylase", "Dedicator of cytokinesis protein 7", "Dehydratase", "Dehydrogenase", "Delta(24)-sterol reductase", "Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial", "Delta-1-pyrroline-5-carboxylate synthase", "Density-regulated protein", "Deoxycytidylate deaminase", "Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial", "Derlin-1", "Derlin-2", "Desmocollin-3", "Desmoglein-2", "Desmoplakin", "Digestive organ expansion factor homolog", "Dihydrofolate reductase", "Dihydrolipoyl dehydrogenase, mitochondrial", "Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial", "Dihydropteridine reductase", "Dihydropyrimidinase-related protein 2", "Dihydropyrimidinase-related protein 3", "Dihydropyrimidinase-related protein 5", "Dipeptidyl peptidase 1", "Dipeptidyl peptidase 3", "Dipeptidyl peptidase 9", "Diphthine methyl ester synthase", "Disks large homolog 1", "Disks large-associated protein 5", "Dna-dependent protein kinase catalytic subunit", "Dolichol-phosphate mannosyltransferase subunit 1", "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit", "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1", "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2", "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A", "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B", "Dolichyldiphosphatase 1", "Double-stranded RNA-specific adenosine deaminase", "Down syndrome critical region protein 3", "Drebrin", "Drebrin-like protein", "Dual specificity protein kinase ttk", "Dynactin subunit 1", "Dynactin subunit 2", "Dynamin-1-like protein", "Dynamin-2", "Dynamin-like 120 kDa protein, mitochondrial", "Dynein light chain 1, cytoplasmic", "Dynein light chain 2, cytoplasmic", "Dystonin", "E3 SUMO-protein ligase RanBP2", "E3 ubiquitin-protein ligase ARIH2", "E3 ubiquitin-protein ligase DTX3L", "E3 ubiquitin-protein ligase HUWE1", "E3 ubiquitin-protein ligase Itchy homolog", "E3 ubiquitin-protein ligase MARCH5", "E3 ubiquitin-protein ligase NEDD4-like", "E3 ubiquitin-protein ligase RBBP6", "E3 ubiquitin-protein ligase ZNF598", "E3 ubiquitin-protein ligase listerin", "EH domain-containing protein 1", "EH domain-containing protein 4", "ELKS/Rab6-interacting/CAST family member 1", "ELMO domain-containing protein 2", "ER lumen protein-retaining receptor 1", "ER membrane protein complex subunit 2", "ERK subfamily", "ERO1-like protein alpha", "ERO1-like protein beta", "Early endosome antigen 1", "Electron transfer flavoprotein subunit alpha, mitochondrial", "Electron transfer flavoprotein subunit beta", "Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial", "Elongation factor 1-alpha 2", "Elongation factor 1-beta", "Elongation factor 1-delta", "Elongation factor 2", "Elongation factor Ts, mitochondrial", "Elongation factor Tu, mitochondrial", "Elongation factor-like GTPase 1", "Elongator complex protein 1", "Elongator complex protein 3", "Elongin-B", "Endodeoxyribonuclease", "Endonuclease III-like protein 1", "Endoplasmic reticulum aminopeptidase 1", "Endoplasmic reticulum aminopeptidase 2", "Endoplasmic reticulum metallopeptidase 1", "Endoplasmic reticulum protein SC65", "Endoplasmic reticulum resident protein 29", "Endoplasmin", "Endoribonuclease", "Endoribonuclease Dicer", "Endothelin-converting enzyme 1", "Engulfment and cell motility protein 2", "Enhancer of mRNA-decapping protein 4", "Enhancer of rudimentary homolog", "Enoyl-CoA delta isomerase 1, mitochondrial", "Enoyl-CoA delta isomerase 2, mitochondrial", "Enoyl-CoA hydratase, mitochondrial", "Enzyme", "Enzyme modulator", "Eph family", "Ephrin type-a receptor 7", "Epidermal growth factor receptor substrate 15-like 1", "Epigenetic regulator", "Epimerase family protein SDR39U1", "Epimerase/racemase", "Epiplakin", "Eraser", "Erythrocyte band 7 integral membrane protein", "Esterase", "Ethylmalonyl-CoA decarboxylase", "Eukaryotic peptide chain release factor GTP-binding subunit ERF3A", "Eukaryotic peptide chain release factor subunit 1", "Eukaryotic translation initiation factor 2 subunit 1", "Eukaryotic translation initiation factor 2 subunit 2", "Eukaryotic translation initiation factor 2A", "Eukaryotic translation initiation factor 2D", "Eukaryotic translation initiation factor 3 subunit A", "Eukaryotic translation initiation factor 3 subunit B", "Eukaryotic translation initiation factor 3 subunit D", "Eukaryotic translation initiation factor 3 subunit E", "Eukaryotic translation initiation factor 3 subunit F", "Eukaryotic translation initiation factor 3 subunit H", "Eukaryotic translation initiation factor 3 subunit I", "Eukaryotic translation initiation factor 3 subunit J", "Eukaryotic translation initiation factor 3 subunit L", "Eukaryotic translation initiation factor 4 gamma 1", "Eukaryotic translation initiation factor 4 gamma 2", "Eukaryotic translation initiation factor 4 gamma 3", "Eukaryotic translation initiation factor 4B", "Eukaryotic translation initiation factor 4E", "Eukaryotic translation initiation factor 4E type 2", "Eukaryotic translation initiation factor 4H", "Eukaryotic translation initiation factor 5", "Eukaryotic translation initiation factor 5A-1", "Eukaryotic translation initiation factor 5B", "Eukaryotic translation initiation factor 6", "Exocyst complex component 3", "Exocyst complex component 5", "Exocyst complex component 6", "Exocyst complex component 7", "Exodeoxyribonuclease", "Exonuclease 1", "Exoribonuclease", "Exosome complex component CSL4", "Exosome complex component MTR3", "Exosome complex component RRP4", "Exosome complex component RRP40", "Exosome complex component RRP42", "Exosome complex component RRP43", "Exosome complex component RRP45", "Exosome complex component RRP46", "Exosome complex exonuclease RRP44", "Exportin-1", "Exportin-2", "Exportin-4", "Exportin-5", "Exportin-7", "Exportin-T", "Extracellular matrix glycoprotein", "Extracellular matrix structural protein", "Extracellular structure", "Ezrin", "F-actin-capping protein subunit alpha-1", "F-actin-capping protein subunit beta", "F-type ATPase", "F-type and V-type ATPases", "FACT complex subunit SPT16", "FAD-dependent oxidoreductase domain-containing protein 1", "FAK family", "FRAP subfamily", "FRAY subfamily", "Far upstream element-binding protein 1", "Far upstream element-binding protein 2", "Far upstream element-binding protein 3", "Farnesyl pyrophosphate synthase", "Fascin", "Fatty acid synthase", "Ferrochelatase, mitochondrial", "Flap endonuclease 1", "Focal adhesion kinase 1", "Folate transporter 1", "Forkhead box protein C1", "Fragile X mental retardation syndrome-related protein 1", "Fragile X mental retardation syndrome-related protein 2", "Fumarate hydratase, mitochondrial", "G patch domain-containing protein 4", "G-patch domain and KOW motifs-containing protein", "G-protein", "G-protein coupled receptor", "G-protein modulator", "G-rich sequence factor 1", "G2/mitotic-specific cyclin-B1", "GC-rich sequence DNA-binding factor 2", "GMP synthase [glutamine-hydrolyzing]", "GPI-anchor transamidase", "GSK family", "GSK subfamily", "GTP-binding nuclear protein Ran", "GTP-binding protein 1", "GTP-binding protein Rheb", "GTPase Era, mitochondrial", "GTPase-activating protein and VPS9 domain-containing protein 1", "Galactokinase", "Galactosidase", "Galectin-3", "Gamma-adducin", "Gamma-aminobutyric acid receptor-associated protein-like 2", "Gamma-enolase", "Gamma-glutamyl hydrolase", "Gamma-taxilin", "Gamma-tubulin complex component 2", "Gamma-tubulin complex component 3", "Ganglioside GM2 activator", "General transcription factor 3C polypeptide 3", "General transcription factor 3C polypeptide 5", "General transcription factor IIF subunit 1", "General transcription factor IIH subunit 1", "General transcription factor IIH subunit 4", "General vesicular transport factor p115", "Geranylgeranyl transferase type-2 subunit alpha", "Glia maturation factor beta", "Glucosamine-6-phosphate isomerase 1", "Glucose-6-phosphate 1-dehydrogenase", "Glucose-6-phosphate isomerase", "Glucosidase", "Glucosidase 2 subunit beta", "Glutamate dehydrogenase 1, mitochondrial", "Glutamate--cysteine ligase catalytic subunit", "Glutaminase kidney isoform, mitochondrial", "Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1", "Glutamine--tRNA ligase", "Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial", "Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial", "Glutaredoxin-3", "Glutaredoxin-related protein 5, mitochondrial", "Glutathione hydrolase 7", "Glutathione reductase, mitochondrial", "Glutathione synthetase", "Glyceraldehyde-3-phosphate dehydrogenase", "Glycerol-3-phosphate acyltransferase 4", "Glycerol-3-phosphate dehydrogenase 1-like protein", "Glycerol-3-phosphate dehydrogenase, mitochondrial", "Glycerol-3-phosphate phosphatase", "Glycine dehydrogenase (decarboxylating), mitochondrial", "Glycine--tRNA ligase", "Glycogen debranching enzyme", "Glycogen phosphorylase, brain form", "Glycogen phosphorylase, liver form", "Glycogen synthase kinase-3 beta", "Glycogenin-1", "Glycolipid transfer protein", "Glycosidase", "Glycosylase", "Glycosyltransferase", "Glycylpeptide N-tetradecanoyltransferase 1", "Glyoxylate reductase/hydroxypyruvate reductase", "Golgi SNAP receptor complex member 1", "Golgi pH regulator family", "Golgi ph regulator b", "Golgin subfamily A member 2", "Graves disease carrier protein", "Group XV phospholipase A2", "Growth factor", "GrpE protein homolog 1, mitochondrial", "Gtp:amp phosphotransferase ak3, mitochondrial", "Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12", "Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5", "Guanine nucleotide-binding protein G(i) subunit alpha-1", "Guanine nucleotide-binding protein G(i) subunit alpha-2", "Guanine nucleotide-binding protein G(k) subunit alpha", "Guanine nucleotide-binding protein G(q) subunit alpha", "Guanine nucleotide-binding protein subunit alpha-13", "Guanyl-nucleotide exchange factor", "H(+)/Cl(-) exchange transporter 3", "H(+)/Cl(-) exchange transporter 7", "H/ACA ribonucleoprotein complex subunit 1", "H/ACA ribonucleoprotein complex subunit 2", "HBS1-like protein", "HDAC class I", "HEAT repeat-containing protein 1", "HEAT repeat-containing protein 6", "HIV Tat-specific factor 1", "Haloacid dehalogenase-like hydrolase domain-containing 5", "Haloacid dehalogenase-like hydrolase domain-containing protein 2", "Heat shock protein 75 kDa, mitochondrial", "Heat shock protein HSP 90-alpha", "Heat shock protein HSP 90-beta", "Helicase", "Helix-turn-helix transcription factor", "Hepatoma-derived growth factor", "Hepatoma-derived growth factor-related protein 2", "Hepatoma-derived growth factor-related protein 3", "Heterogeneous nuclear ribonucleoprotein F", "Heterogeneous nuclear ribonucleoprotein H", "Heterogeneous nuclear ribonucleoprotein H2", "Heterogeneous nuclear ribonucleoprotein H3", "Heterogeneous nuclear ribonucleoprotein K", "Heterogeneous nuclear ribonucleoprotein M", "Heterogeneous nuclear ribonucleoprotein Q", "Heterogeneous nuclear ribonucleoprotein R", "Heterotrimeric G-protein", "Hexokinase family", "Hexokinase-1", "Hexokinase-2", "High affinity cationic amino acid transporter 1", "High mobility group protein B1", "High mobility group protein B2", "High mobility group protein B3", "High mobility group protein HMG-I/HMG-Y", "Histidine triad nucleotide-binding protein 2, mitochondrial", "Histidine triad nucleotide-binding protein 3", "Histone", "Histone H1.0", "Histone H1.2", "Histone H1.3", "Histone H1.4", "Histone H1x", "Histone H4", "Histone acetyltransferase KAT7", "Histone acetyltransferase type B catalytic subunit", "Histone deacetylase", "Histone deacetylase 1", "Histone deacetylase 2", "Histone deacetylase complex subunit SAP18", "Histone-lysine N-methyltransferase NSD2", "Histone-lysine N-methyltransferase NSD3", "Histone-lysine N-methyltransferase SETD2", "Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific", "Hormone", "Hsp90 co-chaperone Cdc37", "Hsp90 family chaperone", "Hydrolase", "Hydroxylase", "Hydroxymethylglutaryl-CoA lyase, mitochondrial", "Hypoxanthine-guanine phosphoribosyltransferase", "IKK family", "ILK subfamily", "ITPK1 family", "Immune response", "Immunoglobulin fold transcription factor", "Immunoglobulin superfamily cell adhesion molecule", "Immunoglobulin-binding protein 1", "Importin subunit alpha-1", "Importin subunit alpha-3", "Importin subunit alpha-4", "Importin subunit alpha-5", "Importin subunit alpha-7", "Importin subunit beta-1", "Importin-11", "Importin-4", "Importin-5", "Importin-7", "Importin-8", "Importin-9", "Inactive serine/threonine-protein kinase vrk3", "Inactive tyrosine-protein kinase 7", "Induced myeloid leukemia cell differentiation protein Mcl-1", "Inhibitor of nuclear factor kappa-b kinase subunit beta", "Inorganic pyrophosphatase", "Inorganic pyrophosphatase 2, mitochondrial", "Inosine triphosphate pyrophosphatase", "Inosine-5'-monophosphate dehydrogenase 1", "Inosine-5'-monophosphate dehydrogenase 2", "Inositol monophosphatase 3", "Inositol polyphosphate 5-phosphatase OCRL-1", "Inositol-tetrakisphosphate 1-kinase", "Insulin-degrading enzyme", "Insulin-like growth factor 2 mRNA-binding protein 1", "Insulin-like growth factor 2 mRNA-binding protein 2", "Insulin-like growth factor 2 mRNA-binding protein 3", "Integrator complex subunit 11", "Integrin beta-1", "Integrin-linked kinase-associated serine/threonine phosphatase 2C", "Integrin-linked protein kinase", "Interferon-induced, double-stranded rna-activated protein kinase", "Interleukin enhancer-binding factor 3", "Intermediate filament", "Intermediate filament binding protein", "Intersectin-2", "Intracellular calcium-sensing protein", "Intracellular chloride channel (clic) family", "Intracellular chloride channel (icc) family", "Ion channel", "Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial", "Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial", "Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial", "Isoleucine--tRNA ligase, cytoplasmic", "Isoleucine--tRNA ligase, mitochondrial", "Isomerase", "Isopentenyl-diphosphate Delta-isomerase 1", "Isovaleryl-CoA dehydrogenase, mitochondrial", "Jumonji domain-containing", "KH domain-containing, RNA-binding, signal transduction-associated protein 1", "KH domain-containing, RNA-binding, signal transduction-associated protein 3", "KRAB box transcription factor", "KRR1 small subunit processome component homolog", "Kinase", "Kinase activator", "Kinase inhibitor", "Kinase modulator", "Kinesin-1 heavy chain", "Kinesin-like protein KIF11", "Kinesin-like protein KIF14", "Kinesin-like protein KIF18A", "Kinesin-like protein KIF18B", "Kinesin-like protein KIF1A", "Kinesin-like protein KIF20A", "Kinesin-like protein KIF22", "Kinesin-like protein KIF23", "Kinesin-like protein KIF2A", "Kinesin-like protein KIF2C", "Kinesin-like protein KIF3A", "Kinetochore protein NDC80 homolog", "Kinetochore protein Nuf2", "Kynurenine--oxoglutarate transaminase 3", "L-2-hydroxyglutarate dehydrogenase, mitochondrial", "L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase", "L-lactate dehydrogenase A chain", "L-lactate dehydrogenase B chain", "LIM domain and actin-binding protein 1", "LU7TM family", "La-related protein 1", "La-related protein 4", "La-related protein 4B", "La-related protein 7", "Lamin-B receptor", "Lamina-associated polypeptide 2, isoform alpha", "Laminin subunit beta-1", "Laminin subunit gamma-1", "Lanosterol 14-alpha demethylase", "Large proline-rich protein BAG6", "Legumain", "Lethal(2) giant larvae protein homolog 1", "Leucine-rich repeat and WD repeat-containing protein 1", "Leucine-rich repeat-containing protein 47", "Leucyl-cystinyl aminopeptidase", "Ligase", "Lipase", "Lipid kinase", "Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial", "Lon protease homolog, mitochondrial", "Long-chain fatty acid transport protein 4", "Long-chain-fatty-acid--CoA ligase 1", "Long-chain-fatty-acid--CoA ligase 3", "Long-chain-fatty-acid--CoA ligase 4", "Long-chain-fatty-acid--CoA ligase 6", "Lupus La protein", "Lyase", "Lymphokine-activated killer t-cell-originated protein kinase", "Lysine demethylase", "Lysine--tRNA ligase", "Lysine-specific demethylase", "Lysine-specific demethylase 3B", "Lysine-specific histone demethylase 1A", "Lysine-specific histone demethylase 1B", "Lysophosphatidic acid phosphatase type 6", "Lysophosphatidylcholine acyltransferase 1", "Lysophospholipid acyltransferase 7", "Lysosomal Pro-X carboxypeptidase", "Lysosomal acid lipase/cholesteryl ester hydrolase", "Lysosomal acid phosphatase", "Lysosomal alpha-glucosidase", "Lysosomal protective protein", "Lysosome membrane protein 2", "Lysosome-associated membrane glycoprotein 1", "Lysosome-associated membrane glycoprotein 2", "M-phase phosphoprotein 8", "MAGUK p55 subfamily member 2", "MAGUK p55 subfamily member 6", "MAGUK p55 subfamily member 7", "MAP7 domain-containing protein 1", "MAPK family", "MCU family", "MLK family", "MMS19 nucleotide excision repair protein homolog", "MST subfamily", "Magnesium transporter protein 1", "Major facilitator superfamily domain-containing protein 3", "Major histocompatibility complex antigen", "Malate dehydrogenase, cytoplasmic", "Malate dehydrogenase, mitochondrial", "Mannose-6-phosphate isomerase", "Mediator of RNA polymerase II transcription subunit 14", "Medium-chain specific acyl-CoA dehydrogenase, mitochondrial", "Melanoma inhibitory activity protein 2", "Melanoma-associated antigen D2", "Membralin", "Membrane trafficking regulatory protein", "Membrane-associated progesterone receptor component 1", "Membrane-associated progesterone receptor component 2", "Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase", "Metalloprotease", "Metastasis-associated protein MTA1", "Metastasis-associated protein MTA2", "Methionine aminopeptidase 1", "Methionine--tRNA ligase, mitochondrial", "Methyl-CpG-binding domain", "Methyl-CpG-binding protein 2", "Methyl-lysine/arginine binding protein", "Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial", "Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial", "Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial", "Methylmalonyl-CoA mutase, mitochondrial", "Methylosome subunit pICln", "Methylsterol monooxygenase 1", "Methyltransferase", "Methyltransferase-like protein 7B", "Microsomal glutathione S-transferase 2", "Microsomal glutathione S-transferase 3", "Microtubule binding motor protein", "Microtubule family cytoskeletal protein", "Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5", "Microtubule-associated protein 1A", "Microtubule-associated protein 1B", "Microtubule-associated protein 1S", "Microtubule-associated protein RP/EB family member 1", "Microtubule-associated protein RP/EB family member 2", "Minor histocompatibility antigen H13", "Miscellaneous SLC25 mitochondrial transporters", "Mitochondrial 2-oxodicarboxylate carrier", "Mitochondrial 2-oxoglutarate/malate carrier protein", "Mitochondrial Rho GTPase 1", "Mitochondrial Rho GTPase 2", "Mitochondrial amino acid transporter subfamily", "Mitochondrial cardiolipin hydrolase", "Mitochondrial carnitine/acylcarnitine carrier protein", "Mitochondrial carrier homolog 1", "Mitochondrial carrier homolog 2", "Mitochondrial di- and tri-carboxylic acid transporter subfamily", "Mitochondrial dicarboxylate carrier", "Mitochondrial folate transporter/carrier", "Mitochondrial import inner membrane translocase subunit Tim10 B", "Mitochondrial import receptor subunit TOM20 homolog", "Mitochondrial import receptor subunit TOM40 homolog", "Mitochondrial inner membrane protein OXA1L", "Mitochondrial intermediate peptidase", "Mitochondrial nucleotide transporter subfamily", "Mitochondrial ornithine transporter 1", "Mitochondrial phosphate transporters", "Mitochondrial proton/calcium exchanger protein", "Mitochondrial pyruvate carrier 2", "Mitochondrial thiamine pyrophosphate carrier", "Mitochondrial-processing peptidase subunit alpha", "Mitochondrial-processing peptidase subunit beta", "Mitofusin-1", "Mitofusin-2", "Mitogen-activated protein kinase 1", "Mitogen-activated protein kinase 14", "Mitotic checkpoint protein BUB3", "Mitotic checkpoint serine/threonine-protein kinase bub1 beta", "Moesin", "Molybdate-anion transporter", "Monoacylglycerol lipase ABHD12", "Monoacylglycerol lipase ABHD6", "Monocarboxylate transporter 1", "Monofunctional C1-tetrahydrofolate synthase, mitochondrial", "Mortality factor 4-like protein 1", "Mortality factor 4-like protein 2", "Mpv17-like protein 2", "Mucosa-associated lymphoid tissue lymphoma translocation protein 1", "Multidrug resistance protein 1", "Multidrug resistance-associated protein 4", "Multifunctional protein ADE2", "Mutase", "Myb-binding protein 1A", "Myelin expression factor 2", "Myosin light polypeptide 6", "Myosin phosphatase Rho-interacting protein", "Myotubularin-related protein 2", "Myotubularin-related protein 6", "N-acetylgalactosamine-6-sulfatase", "N-acetylgalactosaminyltransferase 7", "N-acetylglucosamine-6-sulfatase", "N-acylneuraminate cytidylyltransferase", "N-alpha-acetyltransferase 10", "N-alpha-acetyltransferase 15, NatA auxiliary subunit", "N-alpha-acetyltransferase 25, NatB auxiliary subunit", "N-alpha-acetyltransferase 35, NatC auxiliary subunit", "N-alpha-acetyltransferase 50", "N-terminal Xaa-Pro-Lys N-methyltransferase 1", "N-terminal kinase-like protein", "NAD(P) transhydrogenase, mitochondrial", "NAD-dependent malic enzyme, mitochondrial", "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial", "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13", "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5", "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8", "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial", "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4", "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial", "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9", "NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial", "NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial", "NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial", "NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial", "NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial", "NADH-ubiquinone oxidoreductase chain 1", "NADP-dependent malic enzyme", "NADPH:adrenodoxin oxidoreductase, mitochondrial", "NAK family", "NEDD8-activating enzyme E1 catalytic subunit", "NEDD8-activating enzyme E1 regulatory subunit", "NEK family", "NF-X1-type zinc finger protein NFXL1", "NF-kappa-B-repressing factor", "NHP2-like protein 1", "NLR family member X1", "NRBP family", "Na+/K+-ATPases", "Nardilysin", "Neurofibromin", "Neurolysin, mitochondrial", "Neuropathy target esterase", "Neutral alpha-glucosidase AB", "Neutral amino acid transporter B(0)", "Neutral cholesterol ester hydrolase 1", "Nibrin", "Nicotinamide phosphoribosyltransferase", "Nipped-B-like protein", "Nischarin", "Non-POU domain-containing octamer-binding protein", "Non-histone chromosomal protein HMG-17", "Non-motor actin binding protein", "Non-motor microtubule binding protein", "Non-protein kinase", "Nuclear RNA export factor 1", "Nuclear cap-binding protein subunit 1", "Nuclear migration protein nudC", "Nuclear pore complex protein Nup107", "Nuclear pore complex protein Nup153", "Nuclear pore complex protein Nup160", "Nuclear pore complex protein Nup214", "Nuclear pore complex protein Nup85", "Nuclear pore complex protein Nup88", "Nuclear pore complex protein Nup93", "Nuclear pore complex protein Nup98-Nup96", "Nuclear pore glycoprotein p62", "Nuclear pore membrane glycoprotein 210", "Nuclear receptor coactivator 5", "Nuclear receptor corepressor 1", "Nuclear receptor-binding protein", "Nuclease", "Nucleic acid binding", "Nucleobindin-1", "Nucleobindin-2", "Nucleolar MIF4G domain-containing protein 1", "Nucleolar complex protein 4 homolog", "Nucleolar protein 14", "Nucleolar protein 56", "Nucleolar protein 58", "Nucleolar protein 6", "Nucleolar protein 9", "Nucleolin", "Nucleophosmin", "Nucleoporin GLE1", "Nucleoporin Nup37", "Nucleoporin SEH1", "Nucleoporin p54", "Nucleoside diphosphate kinase A", "Nucleoside diphosphate kinase B", "Nucleoside kinase", "Nucleosome assembly protein 1-like 1", "Nucleosome assembly protein 1-like 4", "Nucleotide kinase", "Nucleotide phosphatase", "Nucleotidyltransferase", "NudC domain-containing protein 2", "NudC domain-containing protein 3", "OCIA domain-containing protein 1", "Obg-like ATPase 1", "Occludin", "Origin recognition complex subunit 2", "Origin recognition complex subunit 3", "Origin recognition complex subunit 5", "Ornithine aminotransferase, mitochondrial", "Other 7TM proteins", "Other group", "Other small molecule kinase", "Oxidase", "Oxidoreductase", "Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial", "Oxygenase", "P-type ATPases", "P38 subfamily", "P53-like transcription factor", "PAKA subfamily", "PC4 and SFRS1-interacting protein", "PDHK family", "PDZ and LIM domain protein 1", "PDZ and LIM domain protein 5", "PEK family", "PH-interacting protein", "PHD finger protein 10", "PHD finger protein 3", "PHD finger protein 6", "PI3/PI4 kinase family", "PIKK family", "PIN2/TERF1-interacting telomerase inhibitor 1", "PKA family", "PKC alpha subfamily", "PKC family", "PKN family", "PLK family", "Paired amphipathic helix protein Sin3a", "Palmitoyl-protein thioesterase 1", "Pantothenate kinase 4", "Paraspeckle component 1", "Paxillin", "Pentatricopeptide repeat-containing protein 1, mitochondrial", "Peptidase M20 domain-containing protein 2", "Peptidyl-prolyl cis-trans isomerase FKBP4", "Peptidyl-prolyl cis-trans isomerase FKBP5", "Peptidylprolyl isomerase domain and WD repeat-containing protein 1", "Perilipin-3", "Periodic tryptophan protein 1 homolog", "Peripheral plasma membrane protein cask", "Peroxidase", "Peroxiredoxin-2", "Peroxiredoxin-4", "Peroxiredoxin-6", "Peroxisomal acyl-coenzyme A oxidase 1", "Peroxisomal acyl-coenzyme A oxidase 3", "Peroxisomal biogenesis factor 19", "Peroxisomal membrane protein 2", "Peroxisomal membrane protein PEX14", "Peroxisomal membrane protein PMP34", "Peroxisomal trans-2-enoyl-CoA reductase", "Pescadillo homolog", "Phenylalanine--tRNA ligase beta subunit", "Phosphatase", "Phosphatase activator", "Phosphatase inhibitor", "Phosphatase modulator", "Phosphate carrier protein, mitochondrial", "Phosphatidylethanolamine-binding protein 1", "Phosphatidylinositol 3-kinase regulatory subunit beta", "Phosphatidylinositol 4-kinase alpha", "Phosphatidylinositol 4-kinase beta", "Phosphatidylinositol 4-kinase type 2-alpha", "Phosphatidylinositol 4-phosphate 3-kinase c2 domain-containing subunit alpha", "Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma", "Phosphatidylinositol transfer protein alpha isoform", "Phosphatidylinositol transfer protein beta isoform", "Phosphatidylinositol-binding clathrin assembly protein", "Phosphatidylserine synthase 1", "Phosphatidylserine synthase 2", "Phosphodiesterase", "Phosphofructokinase type A (PFKA) family", "Phosphoglycerate kinase 1", "Phosphoglycerate kinase family", "Phosphoinositide 3-kinase (PI3K) family", "Phosphoinositide 3-kinase regulatory subunit 4", "Phospholipase", "Phospholipase A-2-activating protein", "Phosphoribosyl pyrophosphate synthase-associated protein 1", "Phosphoribosyl pyrophosphate synthase-associated protein 2", "Phosphorylase", "Phosphorylase b kinase regulatory chain family", "Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform", "Phosphorylase b kinase regulatory subunit beta", "Pirin", "Plasma membrane calcium-transporting ATPase 1", "Plasma membrane calcium-transporting ATPase 4", "Plasminogen activator inhibitor 1 RNA-binding protein", "Plastin-3", "Plectin", "Pogo transposable element with ZNF domain", "Poly(A) RNA polymerase, mitochondrial", "Poly(A) polymerase alpha", "Poly(A)-specific ribonuclease PARN", "Poly(ADP-ribose) glycohydrolase", "Poly(rC)-binding protein 1", "Poly(rC)-binding protein 2", "Polycomb protein SUZ12", "Polyglutamine-binding protein 1", "Polymerase", "Polymerase delta-interacting protein 3", "Polypeptide N-acetylgalactosaminyltransferase 1", "Polypeptide N-acetylgalactosaminyltransferase 2", "Polypeptide N-acetylgalactosaminyltransferase 4", "Polyribonucleotide nucleotidyltransferase 1, mitochondrial", "Porphobilinogen deaminase", "Pre-mRNA-processing factor 6", "Pre-mRNA-processing-splicing factor 8", "Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15", "Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16", "Pre-mRNA-splicing factor CWC22 homolog", "Pre-mRNA-splicing factor RBM22", "Pre-mRNA-splicing factor SPF27", "Pre-mRNA-splicing factor SYF1", "Prefoldin subunit 2", "Prefoldin subunit 3", "Prefoldin subunit 5", "Presequence protease, mitochondrial", "Primase", "Probable 18S rRNA (guanine-N(7))-methyltransferase", "Probable ATP-dependent RNA helicase DHX37", "Probable ATP-dependent RNA helicase DHX40", "Probable E3 ubiquitin-protein ligase makorin-2", "Probable RNA-binding protein 19", "Probable U3 small nucleolar RNA-associated protein 11", "Probable global transcription activator SNF2L1", "Probable glutamate--tRNA ligase, mitochondrial", "Probable glutathione peroxidase 8", "Probable histidine--tRNA ligase, mitochondrial", "Probable leucine--tRNA ligase, mitochondrial", "Probable ribosome biogenesis protein RLP24", "Probable serine carboxypeptidase CPVL", "Probable tRNA N6-adenosine threonylcarbamoyltransferase", "Probable tRNA pseudouridine synthase 1", "Procollagen galactosyltransferase 1", "Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1", "Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2", "Programmed cell death 6-interacting protein", "Programmed cell death protein 5", "Prolactin regulatory element-binding protein", "Proliferating cell nuclear antigen", "Prolyl 3-hydroxylase 1", "Prolyl endopeptidase", "Propionyl-CoA carboxylase alpha chain, mitochondrial", "Propionyl-CoA carboxylase beta chain, mitochondrial", "Prostaglandin E synthase 2", "Prostaglandin E synthase 3", "Prostaglandin reductase 1", "Prostaglandin reductase 2", "Prostaglandin reductase 3", "Protease", "Protease inhibitor", "Protein AATF", "Protein BUD31 homolog", "Protein DDI1 homolog 2", "Protein FAM177A1", "Protein HIRA", "Protein Hook homolog 2", "Protein Hook homolog 3", "Protein LSM14 homolog B", "Protein Mpv17", "Protein NDRG3", "Protein PAT1 homolog 1", "Protein PRRC2A", "Protein PRRC2B", "Protein PRRC2C", "Protein RRP5 homolog", "Protein Red", "Protein S100-A11", "Protein S100-A13", "Protein SCO1 homolog, mitochondrial", "Protein SCO2 homolog, mitochondrial", "Protein SET", "Protein SYS1 homolog", "Protein Wiz", "Protein XRP2", "Protein angel homolog 1", "Protein arginine N-methyltransferase 1", "Protein arginine N-methyltransferase 3", "Protein arginine N-methyltransferase 5", "Protein arginine methyltransferase", "Protein farnesyltransferase subunit beta", "Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha", "Protein gpr107", "Protein kinase", "Protein kinase C and casein kinase substrate in neurons protein 2", "Protein kinase c beta type", "Protein lin-9 homolog", "Protein methyltransferase", "Protein pelota homolog", "Protein phosphatase", "Protein phosphatase 1G", "Protein phosphatase methylesterase 1", "Protein polybromo-1", "Protein quaking", "Protein regulator of cytokinesis 1", "Protein spinster homolog 1", "Protein strawberry notch homolog 1", "Protein transport protein Sec23A", "Protein transport protein Sec23B", "Protein transport protein Sec24A", "Protein transport protein Sec24B", "Protein transport protein Sec24C", "Protein transport protein Sec31A", "Protein transport protein Sec61 subunit alpha isoform 1", "Protein tweety homolog 3", "Protein-L-isoaspartate(D-aspartate) O-methyltransferase", "Protein/nucleic acid deglycase DJ-1", "Proto-oncogene tyrosine-protein kinase src", "Pterin-4-alpha-carbinolamine dehydratase", "Purine nucleoside phosphorylase", "Puromycin-sensitive aminopeptidase", "Putative ATP-dependent RNA helicase DHX57", "Putative oxidoreductase GLYR1", "Putative phospholipase B-like 2", "Pyrophosphatase", "Pyruvate carboxylase, mitochondrial", "Pyruvate dehydrogenase protein X component, mitochondrial", "Pyruvate kinase pkm", "RIPK family", "RNA 3'-terminal phosphate cyclase", "RNA 3'-terminal phosphate cyclase-like protein", "RNA binding motif protein, X-linked-like-1", "RNA binding protein", "RNA helicase", "RNA polymerase II elongation factor ELL", "RNA-binding motif protein, X chromosome", "RNA-binding protein 12", "RNA-binding protein 12B", "RNA-binding protein 14", "RNA-binding protein 26", "RNA-binding protein 27", "RNA-binding protein 3", "RNA-binding protein 4", "RNA-binding protein EWS", "RNA-binding protein FUS", "RNA-binding protein with serine-rich domain 1", "ROCK subfamily", "RSK family", "RSK subfamily", "Rab GDP dissociation inhibitor alpha", "Rab GDP dissociation inhibitor beta", "Rab GTPase-activating protein 1", "Rab3 GTPase-activating protein non-catalytic subunit", "Rac GTPase-activating protein 1", "Rac-beta serine/threonine-protein kinase", "Radixin", "Ran GTPase-activating protein 1", "Ran-binding protein 3", "Ran-binding protein 6", "Ran-binding protein 9", "Ran-specific GTPase-activating protein", "Rap guanine nucleotide exchange factor 2", "Ras GTPase-activating protein-binding protein 1", "Ras GTPase-activating protein-binding protein 2", "Ras GTPase-activating-like protein IQGAP1", "Ras GTPase-activating-like protein IQGAP3", "Ras-related C3 botulinum toxin substrate 1", "Ras-related protein R-Ras2", "Ras-related protein Ral-A", "Reader", "Receptor", "Receptor expression-enhancing protein 4", "Receptor expression-enhancing protein 5", "Receptor-interacting serine/threonine-protein kinase 1", "Receptor-type tyrosine-protein phosphatase F", "Recombining binding protein suppressor of hairless", "Reductase", "Regulation of nuclear pre-mRNA domain-containing protein 1A", "Regulation of nuclear pre-mRNA domain-containing protein 1B", "Regulation of nuclear pre-mRNA domain-containing protein 2", "Regulator of nonsense transcripts 1", "Regulator of nonsense transcripts 2", "Remodeling and spacing factor 1", "Renin receptor", "Replication factor C subunit 2", "Replication factor C subunit 3", "Replication factor C subunit 4", "Replication factor C subunit 5", "Replication origin binding protein", "Replication protein A 70 kDa DNA-binding subunit", "Reticulocalbin-1", "Reticulocalbin-2", "Retinal dehydrogenase 2", "Retinoid-inducible serine carboxypeptidase", "Retinol dehydrogenase 11", "Retinol dehydrogenase 14", "Rho GDP-dissociation inhibitor 1", "Rho-associated protein kinase 1", "Rho-associated protein kinase 2", "Rho-related GTP-binding protein RhoG", "Rhomboid domain-containing protein 2", "Ribonuclease H2 subunit A", "Ribonuclease P protein subunit p30", "Ribonucleoprotein", "Ribonucleoprotein PTB-binding 1", "Ribonucleoside-diphosphate reductase large subunit", "Ribonucleoside-diphosphate reductase subunit M2", "Ribose-phosphate pyrophosphokinase 2", "Ribosomal L1 domain-containing protein 1", "Ribosomal RNA small subunit methyltransferase NEP1", "Ribosomal protein", "Ribosomal protein s6 kinase alpha-1", "Ribosomal protein s6 kinase alpha-3", "Ribosome biogenesis protein BOP1", "Ribosome biogenesis protein BRX1 homolog", "Ribosome biogenesis regulatory protein homolog", "Ribosome maturation protein SBDS", "Ribosome production factor 1", "Ribosome production factor 2 homolog", "Ribosome-recycling factor, mitochondrial", "S-adenosylhomocysteine hydrolase-like protein 1", "S-adenosylmethionine mitochondrial carrier protein", "S-adenosylmethionine synthase isoform type-2", "S-formylglutathione hydrolase", "S-methyl-5'-thioadenosine phosphorylase", "S-phase kinase-associated protein 1", "SAP30-binding protein", "SCY1 family", "SEC23-interacting protein", "SET domain", "SLC superfamily of solute carriers", "SLC1 family of amino acid transporters", "SLC12 family of cation-coupled chloride transporters", "SLC16 family of monocarboxylate transporters", "SLC19 family of vitamin transporters", "SLC22 family of organic cation and anion transporters", "SLC25 family of mitochondrial transporters", "SLC27 family of fatty acid transporters", "SLC3 and SLC7 families of heteromeric amino acid transporters (HATs)", "SLC3 family", "SLC33 acetylCoA transporter", "SLC35 family of nucleotide sugar transporters", "SLC39 family of metal ion transporters", "SLC4 family of bicarbonate transporters", "SLC5 family of sodium-dependent glucose transporters", "SLC54 Mitochondrial pyruvate carriers", "SLC55 Mitochondrial cation/proton exchangers", "SLC56 Sideroflexins", "SLC58 MagT-like magnesium transporter family", "SLC61 Molybdate transporter family", "SLC63 Sphingosine-phosphate transporters", "SLC7 family", "SLK subfamily", "SNARE protein", "SNW domain-containing protein 1", "SRC family", "SRPK family", "STE group", "STE20 family", "SUMO-activating enzyme subunit 1", "SUMO-activating enzyme subunit 2", "SUN domain-containing protein 1", "SUN domain-containing protein 2", "SURP and G-patch domain-containing protein 1", "SURP and G-patch domain-containing protein 2", "SWI/SNF complex subunit SMARCC1", "SWI/SNF complex subunit SMARCC2", "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1", "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5", "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1", "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1", "Sal-like protein 2", "Sarcolemmal membrane-associated protein", "Sarcoplasmic/endoplasmic reticulum calcium ATPase 2", "Scavenger receptor class B member 1", "Sec1 family domain-containing protein 1", "Sec1 family domain-containing protein 2", "Secretory carrier-associated membrane protein 1", "Secretory carrier-associated membrane protein 2", "Secretory carrier-associated membrane protein 3", "Secretory carrier-associated membrane protein 4", "Sentrin-specific protease 3", "Septin-11", "Septin-2", "Septin-7", "Septin-9", "Serine hydroxymethyltransferase, cytosolic", "Serine hydroxymethyltransferase, mitochondrial", "Serine palmitoyltransferase 1", "Serine palmitoyltransferase 2", "Serine protease", "Serine protease inhibitor", "Serine--tRNA ligase, cytoplasmic", "Serine--tRNA ligase, mitochondrial", "Serine/arginine repetitive matrix protein 1", "Serine/arginine-rich splicing factor 1", "Serine/arginine-rich splicing factor 10", "Serine/arginine-rich splicing factor 11", "Serine/arginine-rich splicing factor 3", "Serine/arginine-rich splicing factor 4", "Serine/arginine-rich splicing factor 5", "Serine/arginine-rich splicing factor 7", "Serine/arginine-rich splicing factor 9", "Serine/threonine-protein kinase 26", "Serine/threonine-protein kinase 3", "Serine/threonine-protein kinase 4", "Serine/threonine-protein kinase mtor", "Serine/threonine-protein kinase n1", "Serine/threonine-protein kinase n2", "Serine/threonine-protein kinase nek9", "Serine/threonine-protein kinase osr1", "Serine/threonine-protein kinase pak 2", "Serine/threonine-protein kinase plk1", "Serine/threonine-protein kinase prp4 homolog", "Serine/threonine-protein kinase smg1", "Serine/threonine-protein kinase tousled-like 2", "Serine/threonine-protein kinase vrk1", "Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform", "Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform", "Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform", "Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform", "Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform", "Serine/threonine-protein phosphatase 2A activator", "Serine/threonine-protein phosphatase 4 regulatory subunit 1", "Serine/threonine-protein phosphatase 6 regulatory subunit 3", "Serine/threonine-protein phosphatase PP1-alpha catalytic subunit", "Serine/threonine-protein phosphatase PP1-beta catalytic subunit", "Serpin B6", "Serpin H1", "Set1/Ash2 histone methyltransferase complex subunit ASH2", "Sex comb on midleg-like protein 2", "Sialic acid synthase", "Sideroflexin-1", "Sideroflexin-2", "Sigma intracellular receptor 2", "Signal peptidase complex catalytic subunit SEC11A", "Signal peptidase complex subunit 2", "Signal peptidase complex subunit 3", "Signal peptide peptidase-like 2A", "Signal recognition particle 14 kDa protein", "Signal recognition particle 54 kDa protein", "Signal recognition particle 9 kDa protein", "Signal recognition particle receptor subunit alpha", "Signal recognition particle subunit SRP68", "Signal transducer and activator of transcription 1-alpha/beta", "Signal transducer and activator of transcription 3", "Signaling", "Single-stranded DNA-binding protein, mitochondrial", "Sister chromatid cohesion protein PDS5 homolog A", "Sister chromatid cohesion protein PDS5 homolog B", "Small GTPase", "Small nuclear ribonucleoprotein E", "Small nuclear ribonucleoprotein Sm D1", "Small nuclear ribonucleoprotein Sm D2", "Small nuclear ribonucleoprotein Sm D3", "Sodium iodide symporter, sodium-dependent multivitamin transporter and sodium-coupled monocarboxylate transporters", "Sodium-dependent multivitamin transporter", "Sodium/potassium-transporting ATPase subunit alpha-1", "Sodium/potassium-transporting ATPase subunit beta-1", "Sodium/potassium-transporting ATPase subunit beta-3", "Solute carrier family 12 member 2", "Solute carrier family 12 member 9", "Solute carrier family 25 member 33", "Solute carrier family 25 member 44", "Solute carrier family 35 member F2", "Something about silencing protein 10", "Sorbitol dehydrogenase", "Sortilin", "Sorting nexin-1", "Sorting nexin-19", "Sorting nexin-2", "Spermatid perinuclear RNA-binding protein", "Spermidine synthase", "Splicing factor 1", "Splicing factor 3A subunit 1", "Splicing factor 3A subunit 2", "Splicing factor 3A subunit 3", "Splicing factor 3B subunit 1", "Splicing factor 3B subunit 3", "Splicing factor 45", "Splicing factor U2AF 35 kDa subunit", "Splicing factor, arginine/serine-rich 15", "Splicing factor, proline- and glutamine-rich", "Splicing factor, suppressor of white-apricot homolog", "Splicing regulatory glutamine/lysine-rich protein 1", "Squalene monooxygenase", "Squamous cell carcinoma antigen recognized by T-cells 3", "Src substrate cortactin", "Srsf protein kinase 1", "Srsf protein kinase 2", "Staphylococcal nuclease domain-containing protein 1", "Ste20-like serine/threonine-protein kinase", "Sterol O-acyltransferase 1", "Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating", "Stomatin-like protein 2, mitochondrial", "Storage", "Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial", "Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial", "Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial", "Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial", "Succinate-semialdehyde dehydrogenase, mitochondrial", "Sulfhydryl oxidase 2", "Superoxide dismutase [Mn], mitochondrial", "Surfeit locus protein 6", "Survival motor neuron protein", "Synaptic functional regulator FMR1", "Synaptic vesicle glycoprotein 2A", "Synaptogyrin-2", "Synaptojanin-2-binding protein", "Syntaxin-10", "Syntaxin-12", "Syntaxin-16", "Syntaxin-18", "Syntaxin-4", "Syntaxin-7", "Syntaxin-8", "Syntaxin-binding protein 2", "Syntaxin-binding protein 3", "T-complex protein 1 subunit alpha", "T-complex protein 1 subunit beta", "T-complex protein 1 subunit delta", "T-complex protein 1 subunit epsilon", "T-complex protein 1 subunit eta", "T-complex protein 1 subunit gamma", "T-complex protein 1 subunit theta", "T-complex protein 1 subunit zeta", "T-complex protein 11-like protein 1", "TATA-binding protein-associated factor 2N", "TBC1 domain family member 13", "TBC1 domain family member 15", "TBC1 domain family member 4", "TBC1 domain family member 9B", "THO complex subunit 1", "THO complex subunit 2", "THO complex subunit 3", "THO complex subunit 4", "TK group", "TKL group", "TLK family", "TNF receptor-associated factor 2", "TOPK family", "TP53-binding protein 1", "TRIO family", "TTK family", "Target of EGR1 protein 1", "Targeting protein for Xklp2", "Terminal uridylyltransferase 4", "Testin", "Tetratricopeptide repeat protein 28", "Tgf-beta-activated kinase 1 and map3k7-binding protein 1", "Thimet oligopeptidase", "Thioredoxin domain-containing protein 12", "Thioredoxin domain-containing protein 17", "Thioredoxin domain-containing protein 9", "Thioredoxin reductase 1, cytoplasmic", "Thioredoxin-dependent peroxide reductase, mitochondrial", "Thiosulfate sulfurtransferase", "Threonine--tRNA ligase, cytoplasmic", "Threonine--tRNA ligase, mitochondrial", "Thymidine kinase family", "Thymidine kinase, cytosolic", "Thymidylate kinase", "Thymidylate kinase family", "Thymidylate synthase", "Thyroid adenoma-associated protein", "Thyroid hormone receptor-associated protein 3", "Tight junction", "Tight junction protein ZO-1", "Tight junction protein ZO-2", "Torsin-1A", "Torsin-1B", "Trafficking protein particle complex subunit 4", "Trans-Golgi network integral membrane protein 2", "Transaminase", "Transcription activator BRG1", "Transcription cofactor", "Transcription elongation factor A protein 1", "Transcription elongation factor SPT6", "Transcription elongation regulator 1", "Transcription factor", "Transcription initiation factor IIE subunit beta", "Transcription initiation factor TFIID subunit 6", "Transcription initiation protein SPT3 homolog", "Transcriptional activator protein Pur-alpha", "Transcriptional repressor p66-alpha", "Transcriptional repressor p66-beta", "Transducin-like enhancer protein 3", "Transferase", "Transferrin receptor protein 1", "Transformer-2 protein homolog alpha", "Transformer-2 protein homolog beta", "Transgelin-2", "Transketolase", "Translation elongation factor", "Translation factor", "Translation factor GUF1, mitochondrial", "Translation initiation factor", "Translation release factor", "Translationally-controlled tumor protein", "Translocation protein SEC63 homolog", "Translocon-associated protein subunit alpha", "Transmembrane 9 superfamily member 2", "Transmembrane 9 superfamily member 3", "Transmembrane 9 superfamily member 4", "Transmembrane emp24 domain-containing protein 10", "Transmembrane emp24 domain-containing protein 2", "Transmembrane emp24 domain-containing protein 7", "Transmembrane emp24 domain-containing protein 9", "Transmembrane protein 115", "Transport and Golgi organization protein 1 homolog", "Transporter", "Transportin-1", "Transportin-2", "Transportin-3", "Tricarboxylate transport protein, mitochondrial", "Trifunctional enzyme subunit alpha, mitochondrial", "Trifunctional enzyme subunit beta, mitochondrial", "Trifunctional purine biosynthetic protein adenosine-3", "Triosephosphate isomerase", "Tripeptidyl-peptidase 1", "Tripeptidyl-peptidase 2", "Triple functional domain protein", "Trophoblast glycoprotein", "Tropomodulin-3", "Tropomyosin alpha-3 chain", "Tropomyosin alpha-4 chain", "Tryptophan--tRNA ligase, cytoplasmic", "Tubulin", "Tubulin beta chain", "Tubulin beta-2A chain", "Tubulin beta-2B chain", "Tubulin beta-3 chain", "Tubulin beta-4A chain", "Tubulin beta-6 chain", "Tubulin-folding cofactor B", "Tubulin-specific chaperone A", "Tubulin-specific chaperone D", "Tubulin-specific chaperone E", "Tudor and KH domain-containing protein", "Tudor domain", "Tuftelin-interacting protein 11", "Tumor susceptibility gene 101 protein", "Twinfilin-2", "Twinkle protein, mitochondrial", "Type II PI4K subfamily", "Type III PI4K subfamily", "Tyrosine--tRNA ligase, cytoplasmic", "Tyrosine--tRNA ligase, mitochondrial", "Tyrosine-protein kinase csk", "Tyrosine-protein kinase lyn", "U1 small nuclear ribonucleoprotein 70 kDa", "U1 small nuclear ribonucleoprotein A", "U2 small nuclear ribonucleoprotein A'", "U2 small nuclear ribonucleoprotein B''", "U2 snRNP-associated SURP motif-containing protein", "U3 small nucleolar RNA-associated protein 14 homolog A", "U3 small nucleolar RNA-associated protein 6 homolog", "U3 small nucleolar ribonucleoprotein protein IMP3", "U3 small nucleolar ribonucleoprotein protein IMP4", "U3 small nucleolar ribonucleoprotein protein MPP10", "U4/U6 small nuclear ribonucleoprotein Prp3", "U4/U6 small nuclear ribonucleoprotein Prp31", "U4/U6 small nuclear ribonucleoprotein Prp4", "U4/U6.U5 tri-snRNP-associated protein 1", "U4/U6.U5 tri-snRNP-associated protein 2", "U6 snRNA-associated Sm-like protein LSm2", "U6 snRNA-associated Sm-like protein LSm4", "U6 snRNA-associated Sm-like protein LSm6", "U6 snRNA-associated Sm-like protein LSm7", "UDP-glucose:glycoprotein glucosyltransferase 1", "UMP-CMP kinase", "UV excision repair protein RAD23 homolog A", "UV excision repair protein RAD23 homolog B", "Ubiquitin carboxyl-terminal hydrolase 10", "Ubiquitin carboxyl-terminal hydrolase 11", "Ubiquitin carboxyl-terminal hydrolase 14", "Ubiquitin carboxyl-terminal hydrolase 19", "Ubiquitin carboxyl-terminal hydrolase 28", "Ubiquitin carboxyl-terminal hydrolase 36", "Ubiquitin carboxyl-terminal hydrolase 47", "Ubiquitin carboxyl-terminal hydrolase 5", "Ubiquitin carboxyl-terminal hydrolase 7", "Ubiquitin carboxyl-terminal hydrolase isozyme L5", "Ubiquitin conjugation factor E4 A", "Ubiquitin thioesterase OTU1", "Ubiquitin thioesterase OTUB1", "Ubiquitin-conjugating enzyme E2 L3", "Ubiquitin-like modifier-activating enzyme 1", "Ubiquitin-like modifier-activating enzyme 6", "Ubiquitin-like-conjugating enzyme ATG3", "Ubiquitin-protein ligase", "Unclassified protein", "Unconventional myosin-Ib", "Unconventional myosin-Ic", "Unconventional myosin-Id", "Unconventional myosin-VI", "Uridine kinase family", "Uridine-cytidine kinase 2", "V-type ATPase", "V-type proton ATPase 116 kDa subunit a isoform 1", "V-type proton ATPase 116 kDa subunit a isoform 2", "V-type proton ATPase catalytic subunit A", "V-type proton ATPase subunit B, brain isoform", "V-type proton ATPase subunit C 1", "V-type proton ATPase subunit D", "V-type proton ATPase subunit H", "V-type proton ATPase subunit d 1", "VIP36-like protein", "VPS15 family", "VRK family", "Vacuolar protein sorting-associated protein 18 homolog", "Vacuolar protein sorting-associated protein 26A", "Vacuolar protein sorting-associated protein 29", "Vacuolar protein sorting-associated protein 33A", "Vacuolar protein sorting-associated protein 33B", "Vacuolar protein sorting-associated protein 35", "Vacuolar protein sorting-associated protein 45", "Vacuolar protein sorting-associated protein 4A", "Vacuolar protein sorting-associated protein 4B", "Vacuolar protein sorting-associated protein 52 homolog", "Very long-chain specific acyl-CoA dehydrogenase, mitochondrial", "Very-long-chain enoyl-CoA reductase", "Vesicle coat protein", "Vesicle-associated membrane protein 7", "Vesicle-associated membrane protein-associated protein A", "Vesicle-associated membrane protein-associated protein B/C", "Vesicle-fusing ATPase", "Vesicular integral-membrane protein VIP36", "WASH complex subunit 5", "WD repeat and HMG-box DNA-binding protein 1", "WD repeat-containing protein 1", "WD repeat-containing protein 74", "WD repeat-containing protein 82", "WEE family", "Winged helix/forkhead transcription factor", "Writer", "X-ray repair cross-complementing protein 5", "X-ray repair cross-complementing protein 6", "Xaa-Pro dipeptidase", "YEATS domain-containing protein 2", "YEATS domain-containing protein 4", "YLP motif-containing protein 1", "YSK subfamily", "Zinc finger CCCH domain-containing protein 11A", "Zinc finger CCCH domain-containing protein 15", "Zinc finger CCCH domain-containing protein 7A", "Zinc finger CCHC domain-containing protein 8", "Zinc finger MYM-type protein 2", "Zinc finger MYM-type protein 4", "Zinc finger RNA-binding protein", "Zinc finger ZZ-type and EF-hand domain-containing protein 1", "Zinc finger protein 281", "Zinc finger protein 622", "Zinc finger protein ubi-d4", "Zinc finger transcription factor", "Zinc transporter ZIP14", "Zyxin", "[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial", "[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial", "[pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial", "[pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial", "c-Myc-binding protein", "eIF-2-alpha kinase activator GCN1", "eukaryotic two domain clade \"e\" sub-subfamily", "m7GpppX diphosphatase", "mRNA export factor", "mRNA polyadenylation factor", "mRNA processing factor", "mRNA splicing factor", "mRNA-decapping enzyme 1B", "pre-mRNA 3' end processing protein WDR33", "rRNA 2'-O-methyltransferase fibrillarin", "tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6", "tRNA (cytosine(34)-C(5))-methyltransferase", "tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4", "tRNA pseudouridine synthase A"], "available_proteins": ["AARS", "AARS2", "AASDHPPT", "AATF", "ABCB1", "ABCB10", "ABCB6", "ABCB7", "ABCB8", "ABCC4", "ABCD3", "ABCF1", "ABCF2", "ABCF3", "ABHD12", "ABHD6", "ACAA1", "ACAA2", "ACAD11", "ACAD9", "ACADM", "ACADVL", "ACAT1", "ACAT2", "ACBD5", "ACLY", "ACO1", "ACO2", "ACOT7", "ACOT8", "ACOT9", "ACOX1", "ACOX3", "ACP2", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACSL6", "ACTL6A", "ACTR1A", "ACTR1B", "ACTR2", "ACTR3", "ACTR8", "ADA", "ADAR", "ADD1", "ADD3", "ADH5", "ADI1", "ADK", "ADPGK", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGL", "AHCY", "AHCYL1", "AIFM1", "AIMP1", "AIP", "AK1", "AK2", "AK3", "AK4", "AK6", "AKAP1", "AKR1A1", "AKR1B1", "AKR7A2", "AKT2", "ALDH16A1", "ALDH18A1", "ALDH1A2", "ALDH1B1", "ALDH2", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALG1", "ALYREF", "ANAPC1", "ANGEL1", "ANO6", "ANP32A", "ANP32B", "ANP32E", "AP1B1", "AP1G1", "AP1M1", "AP1S1", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "APEH", "APP", "ARCN1", "ARFIP1", "ARFIP2", "ARG2", "ARHGDIA", "ARID3B", "ARIH2", "ARPC1A", "ARPC3", "ARPC4", "ARVCF", "ASAH1", "ASB6", "ASH2L", "ASNA1", "ASNS", "ATAD2", "ATAD3A", "ATAD3B", "ATG3", "ATIC", "ATL2", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP2B4", "ATP2C1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP6AP2", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1D", "ATP6V1H", "ATP7A", "ATP7B", "ATPAF1", "ATPIF1", "ATXN2L", "AUP1", "AURKA", "BAG6", "BAIAP2", "BCAP31", "BCAS2", "BCKDK", "BCLAF1", "BCR", "BLMH", "BLVRA", "BOP1", "BPNT1", "BRCA1", "BRD2", "BRD4", "BRIX1", "BUB1B", "BUB3", "BUD23", "BUD31", "BZW1", "BZW2", "CAB39", "CACYBP", "CAD", "CALR", "CALU", "CAMK2G", "CAND1", "CAND2", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPRIN1", "CAPZA1", "CAPZB", "CARHSP1", "CARS", "CASK", "CBX1", "CBX2", "CBX3", "CBX5", "CCAR1", "CCAR2", "CCNB1", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2BP2", "CDC37", "CDC42", "CDK1", "CDK12", "CDK2", "CDK4", "CDK5", "CDK6", "CDK9", "CDKN2AIP", "CEBPZ", "CEP170", "CETN2", "CFAP20", "CHAF1A", "CHAF1B", "CHDH", "CHERP", "CHKA", "CHMP3", "CHMP4B", "CHMP5", "CHMP7", "CHORDC1", "CHRAC1", "CHST14", "CHTOP", "CIRBP", "CIT", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLASP2", "CLCC1", "CLCN3", "CLCN7", "CLGN", "CLIC1", "CLNS1A", "CLPTM1", "CLPTM1L", "CLPX", "CLTA", "CLTB", "CLTC", "CLUH", "CMAS", "CMPK1", "CNDP2", "CNN2", "CNN3", "CNOT1", "CNOT4", "CNP", "COIL", "COL4A3BP", "COLEC12", "COLGALT1", "COMT", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS3", "COPS5", "COPS6", "COPS8", "COPZ1", "CORO1B", "CORO1C", "CORO7", "COTL1", "COX2", "COX5A", "COX5B", "COX7A2", "COX7A2L", "CPOX", "CPSF1", "CPSF3", "CPSF6", "CPSF7", "CPT1A", "CPT2", "CPVL", "CRNKL1", "CRTAP", "CS", "CSE1L", "CSGALNACT2", "CSK", "CSNK1A1", "CSNK2A1", "CSNK2A2", "CSNK2B", "CSRP2", "CSTB", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTNNA1", "CTNND1", "CTPS1", "CTPS2", "CTSA", "CTSC", "CTTN", "CUL1", "CUL2", "CUL4A", "CUL4B", "CUL5", "CWC22", "CYB5B", "CYFIP1", "CYFIP2", "CYP51A1", "DAP3", "DARS", "DARS2", "DBN1", "DBNL", "DBT", "DCAF13", "DCAF8", "DCP1B", "DCPS", "DCTD", "DCTN1", "DCTN2", "DDB1", "DDI2", "DDOST", "DDT", "DENR", "DERL1", "DERL2", "DHCR24", "DHCR7", "DHFR", "DHX15", "DHX29", "DHX37", "DHX38", "DHX40", "DHX57", "DHX8", "DHX9", "DICER1", "DIDO1", "DIEXF", "DIS3", "DLD", "DLG1", "DLGAP5", "DLST", "DNM1L", "DNM2", "DNMT1", "DOCK7", "DOLPP1", "DPF2", "DPH5", "DPM1", "DPP3", "DPP9", "DPYSL2", "DPYSL3", "DPYSL5", "DSC3", "DSCR3", "DSG2", "DSP", "DST", "DTX3L", "DTYMK", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNC2H1", "DYNLL1", "DYNLL2", "EARS2", "EBP", "ECE1", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "EDC4", "EEA1", "EEF1A2", "EEF1B2", "EEF1D", "EEF2", "EFL1", "EFTUD2", "EHD1", "EHD4", "EIF2A", "EIF2AK2", "EIF2D", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3H", "EIF3I", "EIF3J", "EIF3L", "EIF4B", "EIF4E", "EIF4E2", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELL", "ELMO2", "ELMOD2", "ELOB", "ELP1", "ELP3", "EMC2", "EMG1", "ENO1", "ENO2", "EPHA7", "EPHX2", "EPPK1", "EPRS", "EPS15L1", "ERAL1", "ERAP1", "ERAP2", "ERC1", "ERH", "ERMP1", "ERO1A", "ERO1B", "ERP29", "ESD", "ETF1", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXO1", "EXOC3", "EXOC5", "EXOC6", "EXOC7", "EXOSC1", "EXOSC2", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC8", "EXOSC9", "EZR", "FAHD1", "FAM177A1", "FARSB", "FASN", "FBL", "FDPS", "FDXR", "FECH", "FEN1", "FH", "FKBP4", "FKBP5", "FMR1", "FNTA", "FNTB", "FOXC1", "FOXRED1", "FSCN1", "FUBP1", "FUBP3", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GAK", "GALK1", "GALM", "GALNS", "GALNT1", "GALNT2", "GALNT4", "GALNT7", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GATAD2B", "GATB", "GCAT", "GCFC2", "GCLC", "GCN1", "GDI1", "GDI2", "GFPT1", "GGH", "GGT7", "GINS2", "GLB1", "GLDC", "GLE1", "GLRX3", "GLRX5", "GLS", "GLTP", "GLUD1", "GLYR1", "GM2A", "GMFB", "GMPS", "GNA13", "GNAI1", "GNAI2", "GNAI3", "GNAQ", "GNE", "GNG12", "GNG5", "GNPDA1", "GNS", "GOLGA2", "GOSR1", "GPAT4", "GPATCH4", "GPD1L", "GPD2", "GPI", "GPKOW", "GPR107", "GPR89B", "GPT2", "GPX8", "GRHPR", "GRPEL1", "GRSF1", "GSK3B", "GSPT1", "GSR", "GSS", "GTF2E2", "GTF2F1", "GTF2H1", "GTF2H4", "GTF3C3", "GTF3C5", "GTPBP1", "GUF1", "GYG1", "H1F0", "H1FX", "H2AFY", "H2AFY2", "H4C1*", "HACL1", "HADHA", "HADHB", "HARS2", "HAT1", "HBS1L", "HCCS", "HDAC1", "HDAC2", "HDGF", "HDGFL2", "HDGFL3", "HDHD2", "HDHD5", "HEATR1", "HEATR6", "HEXA", "HEXB", "HIBADH", "HIBCH", "HINT2", "HINT3", "HIRA", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HM13", "HMBS", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMGCL", "HMGN2", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPM", "HNRNPR", "HOOK2", "HOOK3", "HPRT1", "HSD17B10", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPE1", "HTATSF1", "HUWE1", "IARS", "IARS2", "IDE", "IDH3A", "IDH3B", "IDH3G", "IDI1", "IGBP1", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IK", "IKBKB", "ILF3", "ILK", "ILKAP", "ILVBL", "IMP3", "IMP4", "IMPAD1", "IMPDH1", "IMPDH2", "INTS11", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IQGAP3", "ITCH", "ITGB1", "ITPA", "ITPK1", "ITSN2", "IVD", "JMJD6", "KARS", "KAT7", "KCTD12", "KDELR1", "KDM1A", "KDM1B", "KDM3B", "KHDRBS1", "KHDRBS3", "KHSRP", "KIF11", "KIF14", "KIF18A", "KIF18B", "KIF1A", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF3A", "KIF4A", "KIF5B", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNA6", "KPNB1", "KRR1", "KYAT3", "L2HGDH", "LAMB1", "LAMC1", "LAMP1", "LAMP2", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS2", "LBR", "LDHA", "LDHB", "LETM1", "LGALS3", "LGMN", "LIG1", "LIG3", "LIMA1", "LIN9", "LIPA", "LLGL1", "LMAN2", "LMAN2L", "LNPEP", "LONP1", "LPCAT1", "LRRC47", "LRWD1", "LSM14B", "LSM2", "LSM4", "LSM6", "LSM7", "LTN1", "LYN", "M6PR", "MACF1", "MAGED2", "MAGT1", "MALT1", "MAP1A", "MAP1B", "MAP1S", "MAP7D1", "MAPK1", "MAPK14", "MAPRE1", "MAPRE2", "MARCH5", "MARS2", "MAT2A", "MBOAT7", "MCAM", "MCCC1", "MCCC2", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCU", "MDH1", "MDH2", "ME1", "ME2", "MECP2", "MED14", "METAP1", "METTL7B", "MFN1", "MFN2", "MFSD3", "MFSD5", "MGST2", "MGST3", "MIA2", "MIA3", "MICU1", "MIPEP", "MKRN2", "MMS19", "MORF4L1", "MORF4L2", "MPC2", "MPG", "MPHOSPH10", "MPHOSPH8", "MPI", "MPP1", "MPP2", "MPP6", "MPP7", "MPRIP", "MPST", "MPV17", "MPV17L2", "MRPL1", "MRPL11", "MRPL12", "MRPL14", "MRPL17", "MRPL19", "MRPL2", "MRPL20", "MRPL21", "MRPL22", "MRPL24", "MRPL38", "MRPL39", "MRPL41", "MRPL43", "MRPL44", "MRPL47", "MRPL48", "MRPL49", "MRPL9", "MRPS11", "MRPS16", "MRPS18A", "MRPS27", "MRPS35", "MRPS5", "MRPS7", "MRRF", "MSH2", "MSH3", "MSH6", "MSMO1", "MSN", "MTA1", "MTA2", "MTAP", "MTCH1", "MTCH2", "MTHFD1", "MTHFD1L", "MTHFD2", "MTHFS", "MTMR2", "MTMR6", "MTOR", "MTPAP", "MUT", "MYBBP1A", "MYCBP", "MYEF2", "MYL6", "MYO1B", "MYO1C", "MYO1D", "MYO6", "NAA10", "NAA15", "NAA25", "NAA35", "NAA50", "NAE1", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NARS", "NBN", "NCAPD2", "NCAPD3", "NCBP1", "NCEH1", "NCL", "NCOA5", "NCOR1", "ND1", "NDC80", "NDRG3", "NDUFA10", "NDUFA13", "NDUFA4", "NDUFA5", "NDUFA8", "NDUFA9", "NDUFB4", "NDUFB5", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS6", "NDUFS7", "NDUFS8", "NEDD4L", "NEK9", "NF1", "NFS1", "NFXL1", "NHP2", "NIPBL", "NISCH", "NKRF", "NLN", "NLRX1", "NME1", "NME2", "NMT1", "NNT", "NOC4L", "NOL6", "NOM1", "NONO", "NOP14", "NOP56", "NOP58", "NOP9", "NPEPPS", "NPM1", "NRBP1", "NRDC", "NSD1", "NSD2", "NSD3", "NSDHL", "NSF", "NSUN2", "NT5C2", "NT5C3A", "NT5C3B", "NT5DC1", "NT5DC2", "NTHL1", "NTMT1", "NTPCR", "NUCB1", "NUCB2", "NUDC", "NUDCD2", "NUDCD3", "NUDT1", "NUDT21", "NUDT5", "NUF2", "NUP107", "NUP153", "NUP160", "NUP210", "NUP214", "NUP37", "NUP54", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NXF1", "OAT", "OCIAD1", "OCLN", "OCRL", "OLA1", "OPA1", "ORC2", "ORC3", "ORC5", "OSGEP", "OTUB1", "OXA1L", "OXSR1", "P3H1", "P3H4", "PACSIN2", "PAICS", "PAK2", "PANK4", "PAPOLA", "PAPSS1", "PARG", "PARK7", "PARN", "PATL1", "PBK", "PBRM1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCMT1", "PCNA", "PDCD11", "PDCD5", "PDCD6IP", "PDE12", "PDHX", "PDK1", "PDK3", "PDLIM1", "PDLIM5", "PDP1", "PDS5A", "PDS5B", "PEBP1", "PECR", "PELO", "PEPD", "PES1", "PEX14", "PEX19", "PFDN2", "PFDN5", "PFKL", "PFKM", "PFKP", "PGD", "PGK1", "PGLS", "PGP", "PGRMC1", "PGRMC2", "PHF10", "PHF3", "PHF6", "PHGDH", "PHIP", "PHKA1", "PHKB", "PI4K2A", "PI4KA", "PI4KB", "PICALM", "PIGK", "PIK3C2A", "PIK3R2", "PIK3R4", "PINX1", "PIP4K2C", "PIR", "PITPNA", "PITPNB", "PITRM1", "PKM", "PKMYT1", "PKN1", "PKN2", "PLA2G15", "PLAA", "PLBD2", "PLCG1", "PLD6", "PLEC", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLS3", "PM20D2", "PMPCA", "PMPCB", "PNP", "PNPLA6", "PNPT1", "POGZ", "POLA2", "POLD2", "POLDIP3", "POLE2", "POLG", "POLR1A", "POLR1B", "POLR1C", "POLR2A", "POLR2B", "POLR2C", "POLR2D", "POLR2E", "POLR2G", "POLR2L", "POLR3A", "POLR3B", "POLR3C", "POLRMT", "PPA1", "PPA2", "PPAT", "PPM1G", "PPME1", "PPP1CA", "PPP1CB", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP2R5E", "PPP4R1", "PPP6R3", "PPT1", "PPWD1", "PQBP1", "PRC1", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX6", "PREB", "PREP", "PRIM1", "PRKAA1", "PRKAA2", "PRKACA", "PRKAG1", "PRKCB", "PRKCSH", "PRKDC", "PRMT1", "PRMT3", "PRMT5", "PRPF3", "PRPF31", "PRPF4", "PRPF4B", "PRPF6", "PRPF8", "PRPS2", "PRPSAP1", "PRPSAP2", "PRRC2A", "PRRC2B", "PRRC2C", "PSIP1", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD7", "PSMD8", "PSPC1", "PTCD1", "PTDSS1", "PTDSS2", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK2", "PTK7", "PTPA", "PTPRF", "PURA", "PUS1", "PWP1", "PXMP2", "PXN", "PYGB", "PYGL", "QARS", "QDPR", "QKI", "QRSL1", "QSOX2", "RAB3GAP2", "RABGAP1", "RABGGTA", "RAC1", "RACGAP1", "RAD23A", "RAD23B", "RAE1", "RALA", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP6", "RANBP9", "RANGAP1", "RAPGEF2", "RAVER1", "RBBP6", "RBM12", "RBM12B", "RBM14", "RBM17", "RBM19", "RBM22", "RBM26", "RBM27", "RBM3", "RBM4", "RBMX", "RBMXL1", "RBPJ", "RCL1", "RCN1", "RCN2", "RDH11", "RDH14", "RDX", "RECQL", "REEP4", "REEP5", "RFC2", "RFC3", "RFC4", "RFC5", "RHBDD2", "RHEB", "RHOG", "RHOT1", "RHOT2", "RIPK1", "RNASEH2A", "RNPS1", "ROCK1", "ROCK2", "RP2", "RPA1", "RPF1", "RPF2", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL18", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL38", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPN1", "RPN2", "RPP30", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS26", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RRAS2", "RRM1", "RRM2", "RRS1", "RSF1", "RSL1D1", "RSL24D1", "RTCA", "S100A11", "S100A13", "SAE1", "SALL2", "SAP18", "SAP30BP", "SARS", "SARS2", "SART1", "SART3", "SBDS", "SBNO1", "SCAF4", "SCAMP1", "SCAMP2", "SCAMP3", "SCAMP4", "SCARB1", "SCARB2", "SCFD1", "SCFD2", "SCML2", "SCO1", "SCO2", "SCPEP1", "SCYL1", "SDF4", "SDHA", "SDHB", "SDR39U1", "SEC11A", "SEC23A", "SEC23B", "SEC23IP", "SEC24A", "SEC24B", "SEC24C", "SEC31A", "SEC61A1", "SEC63", "SEH1L", "SENP3", "SEPT11", "SEPT2", "SEPT7", "SEPT9", "SERBP1", "SERPINB6", "SERPINH1", "SET", "SETD2", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B3", "SFPQ", "SFSWAP", "SFXN1", "SFXN2", "SHMT1", "SHMT2", "SIN3A", "SKP1", "SLC12A2", "SLC12A9", "SLC16A1", "SLC19A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A16", "SLC25A17", "SLC25A19", "SLC25A20", "SLC25A21", "SLC25A24", "SLC25A25", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A33", "SLC25A4", "SLC25A44", "SLC25A5", "SLC25A6", "SLC27A4", "SLC33A1", "SLC35B2", "SLC35F2", "SLC39A14", "SLC3A2", "SLC4A2", "SLC5A6", "SLC7A1", "SLK", "SLMAP", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMG1", "SMN1*", "SND1", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNU13", "SNW1", "SNX1", "SNX19", "SNX2", "SOAT1", "SOD2", "SORD", "SORT1", "SPAG9", "SPCS2", "SPCS3", "SPNS1", "SPPL2A", "SPTLC1", "SPTLC2", "SQLE", "SRC", "SREK1", "SRM", "SRP14", "SRP54", "SRP68", "SRP9", "SRPK1", "SRPK2", "SRPRA", "SRRM1", "SRSF1", "SRSF10", "SRSF11", "SRSF3", "SRSF4", "SRSF5", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSR1", "STAG1", "STAG2", "STAT1", "STAT3", "STK26", "STK3", "STK4", "STOM", "STOML2", "STRBP", "STT3A", "STT3B", "STX10", "STX12", "STX16", "STX18", "STX4", "STX7", "STX8", "STXBP2", "STXBP3", "SUCLA2", "SUCLG2", "SUGP1", "SUGP2", "SUN1", "SUN2", "SUPT16H", "SUPT3H", "SUPT6H", "SURF6", "SUZ12", "SV2A", "SYNCRIP", "SYNGR2", "SYNJ2BP", "SYS1", "TAB1", "TAF15", "TAF6", "TAGLN2", "TAP1", "TAP2", "TARS", "TARS2", "TBC1D13", "TBC1D15", "TBC1D4", "TBC1D9B", "TBCA", "TBCB", "TBCD", "TBCE", "TCEA1", "TCERG1", "TCP1", "TCP11L1", "TDRKH", "TECR", "TES", "TFCP2", "TFIP11", "TFRC", "TGOLN2", "THADA", "THOC1", "THOC2", "THOC3", "THOP1", "THRAP3", "TIMM10B", "TJP1", "TJP2", "TK1", "TKT", "TLE3", "TLK2", "TM9SF2", "TM9SF3", "TM9SF4", "TMED10", "TMED2", "TMED7", "TMED9", "TMEM115", "TMEM259", "TMEM97", "TMOD3", "TMPO", "TNPO1", "TNPO2", "TNPO3", "TOE1", "TOMM20", "TOMM40", "TOP1", "TOR1A", "TOR1B", "TP53", "TP53BP1", "TP53BP2", "TPBG", "TPI1", "TPM3", "TPM4", "TPP1", "TPP2", "TPT1", "TPX2", "TRA2A", "TRA2B", "TRAF2", "TRAP1", "TRAPPC4", "TRIO", "TRIP4", "TRMT6", "TROVE2", "TRUB1", "TSFM", "TSG101", "TST", "TTC28", "TTK", "TTYH3", "TUBB", "TUBB2A", "TUBB2B", "TUBB3", "TUBB4A", "TUBB6", "TUBGCP2", "TUBGCP3", "TUFM", "TWF2", "TWNK", "TXLNA", "TXLNG", "TXNDC12", "TXNDC17", "TXNDC9", "TXNRD1", "TYMS", "U2AF1", "U2SURP", "UBA1", "UBA2", "UBA3", "UBA6", "UBE2L3", "UBE4A", "UCHL5", "UCK2", "UGCG", "UGGT1", "UPF1", "UPF2", "UQCR10", "UQCRB", "UQCRC1", "UQCRC2", "USO1", "USP10", "USP11", "USP14", "USP19", "USP28", "USP36", "USP39", "USP47", "USP5", "USP7", "UTP11", "UTP14A", "UTP3", "UTP6", "VAMP7", "VAPA", "VAPB", "VBP1", "VPS18", "VPS26A", "VPS29", "VPS33A", "VPS33B", "VPS35", "VPS45", "VPS4A", "VPS4B", "VPS52", "VRK1", "VRK3", "WARS", "WASHC5", "WDHD1", "WDR1", "WDR33", "WDR4", "WDR74", "WDR82", "WIZ", "WRNIP1", "XAB2", "XPO1", "XPO4", "XPO5", "XPO7", "XPOT", "XRCC5", "XRCC6", "YARS", "YARS2", "YEATS2", "YEATS4", "YLPM1", "YME1L1", "YOD1", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2", "ZC3H11A", "ZC3H15", "ZC3H7A", "ZCCHC11", "ZCCHC8", "ZFR", "ZMPSTE24", "ZMYM2", "ZMYM4", "ZNF281", "ZNF598", "ZNF622", "ZW10", "ZYX", "ZZEF1"], "leading_proteins": ["ABCB10", "ABCB6", "ABCB7", "ABCB8", "ABCD3", "ABHD12", "ACOX3", "ACP2", "ACP6", "ADPGK", "AGL", "AIFM1", "ALDH16A1", "ALG1", "ANO6", "AP3B1", "ASAH1", "ASNA1", "ATL2", "ATP1A1", "ATP2A2", "ATP2B1", "ATP2B4", "ATP2C1", "ATP5B", "ATP5F1", "ATP5I", "ATP6AP2", "ATP6V0A1", "ATP6V0A2", "ATP7A", "ATP7B", "BCAP31", "BCKDK", "BRCA1", "CALU", "CASK", "CETN2", "CHST14", "CIT", "CLCC1", "CLCN3", "CLCN7", "CLPTM1", "CLPTM1L", "COMT", "COPS5", "COPS6", "COX2", "COX5A", "COX7A2", "COX7A2L", "CPT1A", "CPT2", "CPVL", "CSGALNACT2", "CTSA", "CTSC", "CUL1", "CYB5B", "CYP51A1", "DERL2", "DHCR24", "DHCR7", "DLD", "DNM2", "DOLPP1", "ECE1", "EIF3F", "ELMOD2", "ERAP1", "ERAP2", "ERMP1", "FAM177A1", "FECH", "FNTA", "FOXRED1", "GALNT1", "GALNT4", "GGT7", "GM2A", "GNAI1", "GNAI2", "GNAQ", "GNG5", "GOSR1", "GPR89B", "GPX8", "HADHA", "HDGFL2", "HK1", "HM13", "IDE", "IGF2BP2", "IMPAD1", "IPO4", "IPO9", "KDELR1", "KDM1B", "KPNA2", "L2HGDH", "LAMP1", "LAMP2", "LBR", "LETM1", "LNPEP", "LPCAT1", "MARCH5", "MBOAT7", "MCL1", "ME1", "METAP1", "METTL7B", "MFN1", "MFN2", "MFSD3", "MGST2", "MIA2", "MIA3", "MIPEP", "MKRN2", "MPP2", "MPV17", "MPV17L2", "MSMO1", "MTAP", "MTCH1", "MTCH2", "NAMPT", "NAP1L4", "ND1", "NDUFA13", "NDUFA8", "NDUFB4", "NDUFB9", "NEDD4L", "NLRX1", "NNT", "NPEPPS", "NRDC", "NTMT1", "NUCB1", "NUCB2", "NUP37", "OLA1", "OPA1", "OXA1L", "P3H4", "PAPSS1", "PDK3", "PEX14", "PGRMC1", "PGRMC2", "PHGDH", "PIGK", "PITRM1", "PLBD2", "PLD6", "PM20D2", "PMPCA", "PRCP", "PRKAA1", "PRKAA2", "PTDSS1", "PTDSS2", "PTGES2", "PXMP2", "RABGGTA", "RAD23A", "RCN2", "REEP4", "REEP5", "RHBDD2", "RHEB", "RHOG", "RHOT2", "RIPK1", "RPS6KA3", "RRM2", "SCAMP2", "SCARB1", "SCARB2", "SCO1", "SCO2", "SCPEP1", "SDF4", "SDHB", "SEC11A", "SEPT2", "SET", "SLC12A2", "SLC25A1", "SLC25A10", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A16", "SLC25A19", "SLC25A21", "SLC25A24", "SLC25A25", "SLC25A26", "SLC25A32", "SLC25A33", "SLC25A4", "SLC25A44", "SLC25A5", "SLC25A6", "SLC33A1", "SLC35B2", "SLC39A14", "SLC4A2", "SLC7A1", "SNX2", "SPNS1", "SPPL2A", "SPTLC1", "SQLE", "SSR1", "STK4", "STOM", "STT3A", "STX10", "STX12", "STX18", "STX7", "SV2A", "SYNGR2", "SYNJ2BP", "SYS1", "TAP1", "TAP2", "TCP11L1", "TECR", "TGOLN2", "THOP1", "TIMM10B", "TM9SF3", "TMED10", "TMED2", "TMED9", "TMEM97", "TOMM20", "TOMM40", "TPBG", "TPP1", "TRAPPC4", "TRIO", "TTYH3", "TUBB", "TUBB2A", "TUBB2B", "TUBB3", "TUBB4A", "UGCG", "UQCR10", "UQCRC2", "USP28", "WASHC5", "XPO4", "YME1L1", "ZADH2", "ZMPSTE24"]} \ No newline at end of file diff --git a/pharos_protein_category/advanced/idx2term.json b/pharos_protein_category/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..6e0847ffc649d08286e63465c7dfff7898d31ecd --- /dev/null +++ b/pharos_protein_category/advanced/idx2term.json @@ -0,0 +1 @@ +{"0": "Tbio"} \ No newline at end of file diff --git a/pharos_protein_category/advanced/plot_0.png b/pharos_protein_category/advanced/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..a3a01ad13639d5a203aa63c73f64069993e718af --- /dev/null +++ b/pharos_protein_category/advanced/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:5e5eccfbae0f4ce7ce7d155b096aba9a44aec1a5c5705f13d892172debd6ea77 +size 212866 diff --git a/pharos_protein_category/basic/idx2term.json b/pharos_protein_category/basic/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..ddd662d46a4f8971ba47d18342352a728e89ddee --- /dev/null +++ b/pharos_protein_category/basic/idx2term.json @@ -0,0 +1 @@ +{"0": "Tbio", "1": "Tclin"} \ No newline at end of file diff --git a/pharos_protein_category/basic/plot_0.png b/pharos_protein_category/basic/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..d558c909e70425f1897e314b827edc5a9f07629e --- /dev/null +++ b/pharos_protein_category/basic/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:a6843b4e1034cceea83b5332f087580ef3a6ff543e3364ed0f73a70d92b6d473 +size 131696 diff --git a/pharos_protein_category/basic/plot_1.png b/pharos_protein_category/basic/plot_1.png new file mode 100644 index 0000000000000000000000000000000000000000..2b4512f819c72867f19e5299c2fe415b1f868b2c --- /dev/null +++ b/pharos_protein_category/basic/plot_1.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:42f6d5c1e93891be06318bca008adac0ad49654c8649020dbd5d1c1ec784b46a +size 133413 diff --git a/pharos_protein_category/consensus.joblib b/pharos_protein_category/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..dee0e4d013fc98e3010ddadee4ea4ed6d32e72ba --- /dev/null +++ b/pharos_protein_category/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:6bef5c02399605dc418c6f138460f57f109804f36a2981339af8695161730638 +size 79744 diff --git a/pharos_protein_category/df_merge.tsv b/pharos_protein_category/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..b4688293e5394cf2a4afe9a310df600aa6ec732e --- /dev/null +++ b/pharos_protein_category/df_merge.tsv @@ -0,0 +1,2 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Tbio 401 2474 2.9225855700729446 0.0034713822038763 467.6796116504854 2434.25 -0.5416405556668178 0.3215141878443288 119.73666199244032 234.70955636597876 4.704421961664106 0.4116627836259234 0.0442657002638342 0.3956299675377899 0.3085536621392603 0.0123336547951478 0.0128438974886548 diff --git a/pharos_protein_category/metrics.json b/pharos_protein_category/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..9e98985db0aaa07246ba8f0f434bb8b655c5e2ce --- /dev/null +++ b/pharos_protein_category/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3221, + "annotations_size": 4, + "title": "Average number of proteins per term", + "value": 805.0 +} \ No newline at end of file diff --git a/pharos_protein_category/paths.json b/pharos_protein_category/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..e5325b7043d303397f919fee3e588e8d863343ef --- /dev/null +++ b/pharos_protein_category/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/pharos_protein_category/fragment/C201/C201_val_log2fc"} \ No newline at end of file diff --git a/pharos_protein_category/result.tsv b/pharos_protein_category/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..2a63e414200f4458c44c668fbf3adce467aa3836 --- /dev/null +++ b/pharos_protein_category/result.tsv @@ -0,0 +1,3 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Tbio 0.1958601508434253 2.9225855700729446 0.0034713822038763 0.0138133930313458 0.0138855288155053 2474 O14949,Q9BSK2,Q7Z7H8,Q8IXH7,Q8N4Q0,Q8N6G5,Q96PC5,Q9C0H2,Q07065,Q9H061,Q9H2D1,Q9H6V9,Q9NQC3,Q9NS69,Q9P2W9,Q9UDW1,Q9UHX1,Q9Y2R0,Q15800,O15127,P80303,O15173,O43169,O43657,O60637,O95197,P50897,P07602,P17900,P24390,P24539,P43307,Q13505,Q96ED9,Q9UM22,P21796,Q96A26,P51648,O95249,Q13423,Q9UHG3,P57105,P35670,O15118,O95202,O75844,P02545,Q9Y282,O43760,Q4ZIN3,O60499,Q8N8Q8,Q9NX40,Q70HW3,P13073,Q9Y277,Q9Y371,Q15070,P30825,O96005,Q14166,O75208,P51571,Q14108,O60858,Q9H6D7,Q9H6K4,Q8N5M9,Q14257,Q9HB40,Q8WWV3,Q8N511,Q5XKP0,Q93050,Q9NX47,O00165,Q9UBX3,Q8NCH0,Q9HCL2,Q9NZJ7,Q9BUR5,O00461,Q96A33,Q8IV08,Q9Y487,O00264,P13473,P16260,Q5H8A4,P46977,Q06136,Q9NUJ1,P42167,P49916,Q6IPU0,P11117,Q15363,Q15392,Q9BRR6,Q9BT22,Q92542,Q7KZN9,P54802,P55010,Q8NAN2,Q7LGA3,Q96G23,Q9UIJ7,Q9UKU0,P40855,Q9H6H4,P40939,Q567V2,Q9UBV2,Q9GZP9,P16615,Q96PU5,P41208,P22830,O43852,O43175,O14548,Q8N2A8,Q9Y5J9,Q96CU9,Q8TB61,Q92791,Q9P035,Q9Y4P3,Q9UJ14,Q6UXV4,Q5KU26,Q9P1F3,Q12768,P27105,Q13561,Q9BV86,Q9NQX7,O14737,O43493,Q6KCM7,O76024,P67812,Q969Q5,Q96JJ7,Q8NHH9,P11279,Q01105,Q99623,Q9H3K2,Q8TB36,Q9BQT8,Q8TEX9,Q96A57,P49354,Q15043,P55327,Q16880,Q8TCT8,O75503,Q969V5,P08670,Q15041,Q7L5N1,Q92543,Q14739,O00231,Q8IXI1,Q9UG56,O60831,Q8IWA4,P52888,Q9UJS0,Q9Y248,O75153,P28072,P51572,Q5VV42,Q9H3N1,Q8NBX0,Q9NPH0,Q96KA5,Q92896,Q53H12,Q10472,O15254,Q96S66,Q9BT78,Q9Y680,Q08722,P35613,O75381,Q9H3G5,Q9Y619,Q8NF37,Q9Y6Y8,Q9NVI7,Q9H9P8,O94927,O43681,P57088,P61289,Q96AA3,O75486,Q99797,Q9NW15,O43819,Q10713,P22695,Q9NZ01,Q16836,Q96RL7,P07197,O95674,O14925,P98194,Q6NUK1,P50402,Q14168,Q8IZA0,Q9Y512,Q8WXF1,Q16891,O96028,P39210,Q86UT6,O00625,Q9BTX1,Q9H2V7,Q12981,Q9BVG9,O60749,Q04656,P16435,Q15165,Q5JRA6,P20700,Q99733,O15400,O95433,Q53GQ0,Q9UPU5,P27824,P61916,Q6P4Q7,Q7Z3C6,Q9NX63,O75298,Q15645,O14681,O75431,Q96L92,Q99735,Q9UBB4,Q9NWM8,P12236,P26368,Q13641,Q00765,P49755,Q9NVH6,Q9NUT2,Q9NP58,O75880,O00116,P53701,O43252,O75955,P54725,Q04323,P12235,Q6UX53,O15258,O75962,P67936,Q6NTF9,Q96AQ8,O00203,O60313,P06576,P48723,Q9HC21,Q8IY95,Q9UH99,P46379,P07196,P56385,Q14728,Q9BZD4,Q9Y296,Q96N66,O75787,P09622,Q16352,O75330,P53007,Q6UWE0,Q9Y6C9,Q96CS2,Q9Y5X3,Q92604,Q92643,P10644,Q03519,Q8N4A0,Q9Y394,Q96KC8,Q9BUN8,Q9UL46,Q8NHP8,O75323,Q7Z5K2,O14656,Q03252,Q86UE4,Q9C0E2,Q9NRR5,Q9NUQ2,Q5T9A4,Q14789,O96008,O15460,P48651,P63218,Q9Y5A7,Q9BRK5,Q7Z569,Q8NE01,Q15382,P52292,O95831,O43399,P61962,P55209,P57678,Q15388,P35573,Q8TD16,Q03518,P10321,O00584,Q08378,Q14527,Q8TED1,Q9NTJ5,Q9BPX6,Q99828,P21912,P33991,Q13144,Q16706,Q8NFH5,Q96HY6,Q9GZT3,Q16799,Q8IY67,O95140,O75746,O14979,P04920,Q96AG4,O94905,P35269,Q6P2P2,Q9BZG1,Q9P0J1,Q14566,Q08257,Q9BPW8,A1L0T0,O75915,P35232,Q2TAA5,Q86Y82,Q969V3,Q9BQ95,O15498,P20674,Q96RU2,Q9BXW9,Q9NQT5,Q9NVH1,Q9NVT9,P05141,Q9NR31,Q99471,P51530,Q86XL3,P20020,O14773,Q4KMQ2,Q8TAE8,Q9P287,Q5T9L3,Q9UM00,Q92905,Q6ZRP7,O60566,Q5T8D3,Q12959,P61026 401 +Tclin 0.4124246390066508 1.7664909387707568 0.0773135204322783 0.275202599301998 0.1546270408645567 87 Q9P0J0,P38435,P05023,P03886,O43676,O95139,P31350,P06280,Q86Y39,Q16739,O95168,O95299,O96000,Q9Y6M9,Q99720,P49721,Q7L0J3,P10253,P04035,P51970,P14324,P21964 22 diff --git a/pharos_protein_category/selections.json b/pharos_protein_category/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..a6b7838c9fa08fa1fdc1b3b8f0fdc4b4469a014a --- /dev/null +++ b/pharos_protein_category/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["Tbio", "Tchem", "Tclin", "Tdark"], "available_proteins": ["AAAS", "AAR2", "AARS", "AARS2", "AASDHPPT", "AASS", "AATF", "ABCB1", "ABCB10", "ABCB6", "ABCB7", "ABCB8", "ABCC4", "ABCD3", "ABCE1", "ABCF1", "ABCF2", "ABCF3", "ABHD10", "ABHD12", "ABHD14B", "ABHD6", "ABRACL", "ABRAXAS2", "ACAA1", "ACAA2", "ACACA", "ACACB", "ACAD11", "ACAD9", "ACADM", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACBD5", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT8", "ACOT9", "ACOX1", "ACOX3", "ACP1", "ACP2", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACSL6", "ACTL6A", "ACTN1", "ACTN4", "ACTR1A", "ACTR1B", "ACTR2", "ACTR3", "ACTR8", "ADA", "ADAR", "ADD1", "ADD3", "ADH5", "ADI1", "ADK", "ADNP", "ADPGK", "ADRM1", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGK", "AGL", "AGPAT1", "AGPAT5", "AGPS", "AHCTF1", "AHCY", "AHCYL1", "AHNAK", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AK3", "AK4", "AK6", "AKAP1", "AKAP10", "AKAP8", "AKAP8L", "AKAP9", "AKR1A1", "AKR1B1", "AKR7A2", "AKT2", "ALDH16A1", "ALDH18A1", "ALDH1A2", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALG1", "ALG11", "ALG5", "ALKBH5", "ALYREF", "AMOT", "ANAPC1", "ANAPC16", "ANAPC2", "ANAPC4", "ANAPC5", "ANAPC7", "ANGEL1", "ANK3", "ANKFY1", "ANKHD1", "ANKLE2", "ANKRD17", "ANLN", "ANO10", "ANO6", "ANP32A", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA4", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP1M1", "AP1S1", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "APEH", "APEX1", "API5", "APMAP", "APOO", "APOOL", "APP", "APPL1", "APRT", "AQR", "ARCN1", "ARF4", "ARF6", "ARFGAP1", "ARFIP1", "ARFIP2", "ARG2", "ARGLU1", "ARHGAP17", "ARHGDIA", "ARHGEF2", "ARID1A", "ARID2", "ARID3B", "ARIH2", "ARL1", "ARL2", "ARL3", "ARL6IP1", "ARL6IP5", "ARL8A", "ARMC1", "ARMC10", "ARMC6", "ARMCX3", "ARMT1", "ARPC1A", "ARPC2", "ARPC3", "ARPC4", "ARVCF", "ASAH1", "ASB6", "ASCC2", "ASCC3", "ASH2L", "ASNA1", "ASNS", "ASPH", "ASPSCR1", "ATAD1", "ATAD2", "ATAD3A", "ATAD3B", "ATAD5", "ATG3", "ATG9A", "ATIC", "ATL2", "ATP13A1", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP2B4", "ATP2C1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6AP1", "ATP6AP2", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1D", "ATP6V1E1", "ATP6V1H", "ATP7A", "ATP7B", "ATPAF1", "ATPIF1", "ATRIP", "ATXN10", "ATXN2L", "AUP1", "AURKA", "B3GALT6", "B4GAT1", "BABAM1", "BABAM2", "BAG2", "BAG3", "BAG4", "BAG5", "BAG6", "BAIAP2", "BANF1", "BAP18", "BARD1", "BASP1", "BAZ1A", "BAZ1B", "BAZ2A", "BCAP31", "BCAS2", "BCAS3", "BCCIP", "BCKDK", "BCL2L12", "BCLAF1", "BCR", "BCS1L", "BICD2", "BIRC6", "BLM", "BLMH", "BLVRA", "BMS1", "BNIP1", "BOLA2*", "BOP1", "BPNT1", "BPTF", "BRAP", "BRCA1", "BRD1", "BRD2", "BRD4", "BRIX1", "BRMS1L", "BSG", "BTAF1", "BTF3", "BUB1B", "BUB3", "BUD23", "BUD31", "BYSL", "BZW1", "BZW2", "C12orf73", "C17orf75", "C19orf25", "C19orf70", "C1QBP", "C1orf123", "C1orf35", "C2CD5", "C2orf49", "C4orf46", "C5orf51", "C8orf33", "C9orf64", "CAB39", "CACYBP", "CAD", "CALD1", "CALR", "CALU", "CAMK2G", "CAMSAP3", "CAND1", "CAND2", "CANT1", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPNS1", "CAPRIN1", "CAPZA1", "CAPZB", "CARHSP1", "CARS", "CASK", "CAST", "CBR1", "CBX1", "CBX2", "CBX3", "CBX5", "CBX8", "CC2D1A", "CCAR1", "CCAR2", "CCDC134", "CCDC138", "CCDC22", "CCDC47", "CCDC59", "CCDC6", "CCDC86", "CCDC93", "CCDC97", "CCNB1", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2AP", "CD2BP2", "CD3EAP", "CD47", "CDC123", "CDC16", "CDC23", "CDC27", "CDC37", "CDC42", "CDC5L", "CDC73", "CDCA2", "CDCA5", "CDCA7L", "CDCA8", "CDH2", "CDIPT", "CDK1", "CDK12", "CDK2", "CDK4", "CDK5", "CDK5RAP1", "CDK5RAP3", "CDK6", "CDK9", "CDKAL1", "CDKN2A", "CDKN2AIP", "CDS2", "CEBPZ", "CELF1", "CELF2", "CENPB", "CENPI", "CENPP", "CENPV", "CEP170", "CEP44", "CEP55", "CEP72", "CERS2", "CERS5", "CETN2", "CFAP20", "CFL1", "CFL2", "CHAC2", "CHAF1A", "CHAF1B", "CHAMP1", "CHCHD3", "CHD1", "CHD1L", "CHD4", "CHD8", "CHDH", "CHERP", "CHID1", "CHKA", "CHMP2B", "CHMP3", "CHMP4B", "CHMP5", "CHMP7", "CHORDC1", "CHRAC1", "CHST14", "CHTF18", "CHTOP", "CIAPIN1", "CIB1", "CIP2A", "CIRBP", "CISD2", "CIT", "CIZ1", "CKAP2", "CKAP4", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLASP2", "CLCC1", "CLCN3", "CLCN7", "CLGN", "CLIC1", "CLINT1", "CLN5", "CLNS1A", "CLPB", "CLPP", "CLPTM1", "CLPTM1L", "CLPX", "CLSPN", "CLTA", "CLTB", "CLTC", "CLUH", "CMAS", "CMPK1", "CMTR1", "CNDP2", "CNN2", "CNN3", "CNNM3", "CNNM4", "CNOT1", "CNOT4", "CNOT9", "CNP", "COA3", "COA7", "COG2", "COG3", "COG4", "COG5", "COG6", "COG7", "COIL", "COL4A3BP", "COLEC12", "COLGALT1", "COMMD8", "COMT", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS8", "COPZ1", "COQ8A", "COQ9", "CORO1B", "CORO1C", "CORO7", "COTL1", "COX15", "COX18", "COX4I1", "COX5A", "COX5B", "COX6C", "COX7A2", "COX7A2L", "CPD", "CPNE1", "CPNE2", "CPNE3", "CPNE8", "CPOX", "CPSF1", "CPSF2", "CPSF3", "CPSF6", "CPSF7", "CPT1A", "CPT2", "CPVL", "CRK", "CRKL", "CRNKL1", "CRTAP", "CRYZ", "CS", "CSDE1", "CSE1L", "CSGALNACT2", "CSK", "CSNK1A1", "CSNK2A1", "CSNK2A2", "CSNK2B", "CSRP2", "CSTB", "CSTF1", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTNNA1", "CTNNAL1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTPS2", "CTR9", "CTSA", "CTSC", "CTTN", "CTTNBP2NL", "CTU2", "CUL1", "CUL2", "CUL3", "CUL4A", "CUL4B", "CUL5", "CUTA", "CWC15", "CWC22", "CWF19L1", "CXADR", "CXorf56", "CXorf57", "CYB5B", "CYB5R1", "CYB5R3", "CYC1", "CYFIP1", "CYFIP2", "CYP20A1", "CYP51A1", "DAGLB", "DAP3", "DARS", "DARS2", "DAZAP1", "DBN1", "DBNL", "DBT", "DCAF1", "DCAF13", "DCAF7", "DCAF8", "DCAKD", "DCD", "DCP1B", "DCPS", "DCTD", "DCTN1", "DCTN2", "DCTN3", "DCTN4", "DCTPP1", "DCUN1D1", "DCUN1D5", "DCXR", "DDB1", "DDI2", "DDOST", "DDRGK1", "DDT", "DDX1", "DDX10", "DDX17", "DDX18", "DDX20", "DDX21", "DDX23", "DDX24", "DDX27", "DDX28", "DDX39A", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX50", "DDX51", "DDX52", "DDX54", "DDX56", "DDX6", "DEK", "DENND6A", "DENR", "DERL1", "DERL2", "DFFA", "DHCR24", "DHCR7", "DHFR", "DHPS", "DHRS1", "DHRS13", "DHRS7", "DHRS7B", "DHTKD1", "DHX15", "DHX16", "DHX29", "DHX30", "DHX36", "DHX37", "DHX38", "DHX40", "DHX57", "DHX8", "DHX9", "DIAPH1", "DIAPH2", "DIAPH3", "DICER1", "DIDO1", "DIEXF", "DIMT1", "DIS3", "DKC1", "DLAT", "DLD", "DLG1", "DLGAP5", "DLST", "DMAP1", "DNA2", "DNAAF5", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC13", "DNAJC16", "DNAJC2", "DNAJC21", "DNAJC3", "DNAJC7", "DNAJC8", "DNAJC9", "DNM1L", "DNM2", "DNMT1", "DNPH1", "DNTTIP2", "DOCK7", "DOHH", "DOLPP1", "DPF2", "DPH2", "DPH5", "DPM1", "DPP3", "DPP9", "DPY30", "DPYSL2", "DPYSL3", "DPYSL5", "DRG1", "DRG2", "DSC3", "DSCR3", "DSG2", "DSP", "DST", "DSTN", "DTX3L", "DTYMK", "DUS2", "DUSP12", "DUSP3", "DUSP9", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNC2H1", "DYNLL1", "DYNLL2", "EARS2", "EBNA1BP2", "EBP", "ECE1", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "ECSIT", "EDC3", "EDC4", "EDF1", "EDRF1", "EEA1", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EFCAB14", "EFL1", "EFTUD2", "EHBP1", "EHD1", "EHD4", "EI24", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2D", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E", "EIF4E2", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAC2", "ELAVL1", "ELL", "ELMO2", "ELMOD2", "ELOA", "ELOB", "ELP1", "ELP2", "ELP3", "ELP4", "EMC1", "EMC2", "EMC7", "EMD", "EMG1", "EML4", "ENAH", "ENDOD1", "ENO1", "ENO2", "ENY2", "EP400", "EPB41", "EPB41L2", "EPB41L3", "EPB41L5", "EPDR1", "EPHA7", "EPHX1", "EPHX2", "EPN1", "EPPK1", "EPRS", "EPS15L1", "ERAL1", "ERAP1", "ERAP2", "ERBIN", "ERC1", "ERCC2", "ERCC3", "ERCC6L", "ERG28", "ERGIC1", "ERGIC3", "ERH", "ERLIN1", "ERLIN2", "ERMP1", "ERO1A", "ERO1B", "ERP29", "ESD", "ESF1", "ESYT1", "ESYT2", "ETF1", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXD2", "EXO1", "EXOC2", "EXOC3", "EXOC5", "EXOC6", "EXOC7", "EXOC8", "EXOSC1", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC8", "EXOSC9", "EYA4", "EZR", "F11R", "FADS2", "FAF1", "FAF2", "FAH", "FAHD1", "FAHD2A", "FAM114A2", "FAM120A", "FAM129B", "FAM136A", "FAM162A", "FAM177A1", "FAM192A", "FAM208A", "FAM213A", "FAM49B", "FAM50A", "FAM98A", "FAM98B", "FANCD2", "FANCI", "FAR1", "FARP1", "FARP2", "FARSA", "FARSB", "FASN", "FASTKD5", "FAU", "FBL", "FDFT1", "FDPS", "FDXR", "FECH", "FEN1", "FERMT2", "FGFR1OP", "FH", "FHL1", "FHOD1", "FIP1L1", "FIS1", "FKBP10", "FKBP14", "FKBP2", "FKBP3", "FKBP4", "FKBP5", "FKBP7", "FKBP8", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FMR1", "FNBP4", "FNDC3A", "FNTA", "FNTB", "FOCAD", "FOXC1", "FOXK1", "FOXRED1", "FRYL", "FSCN1", "FSD1", "FTO", "FTSJ3", "FUBP1", "FUBP3", "FUCA1", "FUCA2", "FUNDC2", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GADD45GIP1", "GAK", "GALK1", "GALM", "GALNS", "GALNT1", "GALNT2", "GALNT4", "GALNT7", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GATAD2B", "GATB", "GBA", "GBF1", "GCAT", "GCDH", "GCFC2", "GCLC", "GCN1", "GDAP1", "GDI1", "GDI2", "GDPD1", "GEMIN4", "GEMIN5", "GEMIN8", "GET4", "GFM1", "GFPT1", "GGA1", "GGCT", "GGCX", "GGH", "GGT7", "GHDC", "GHITM", "GID4", "GIGYF2", "GINS2", "GINS3", "GINS4", "GLA", "GLB1", "GLCE", "GLDC", "GLE1", "GLG1", "GLMN", "GLO1", "GLOD4", "GLRX3", "GLRX5", "GLS", "GLTP", "GLUD1", "GLYR1", "GM2A", "GMFB", "GMPS", "GNA13", "GNAI1", "GNAI2", "GNAI3", "GNAQ", "GNE", "GNG12", "GNG5", "GNL1", "GNL2", "GNL3", "GNL3L", "GNPAT", "GNPDA1", "GNPNAT1", "GNS", "GOLGA2", "GOLGA3", "GOLGA5", "GOLGB1", "GOLIM4", "GOLT1B", "GORASP2", "GOSR1", "GOT1", "GOT2", "GPAA1", "GPAM", "GPAT4", "GPATCH4", "GPATCH8", "GPD1L", "GPD2", "GPHN", "GPI", "GPKOW", "GPR107", "GPR108", "GPR89B", "GPRASP2", "GPS1", "GPT2", "GPX8", "GRB2", "GRHPR", "GRPEL1", "GRSF1", "GRWD1", "GSK3B", "GSPT1", "GSR", "GSS", "GSTK1", "GSTM3", "GSTO1", "GSTZ1", "GTF2E1", "GTF2E2", "GTF2F1", "GTF2H1", "GTF2H4", "GTF2I", "GTF3C1", "GTF3C2", "GTF3C3", "GTF3C4", "GTF3C5", "GTPBP1", "GTPBP10", "GTPBP3", "GTPBP4", "GUF1", "GXYLT1", "GYG1", "GYS1", "H1F0", "H1FX", "H2AFY", "H2AFY2", "H4C1*", "HACD3", "HACL1", "HADH", "HADHA", "HADHB", "HARS2", "HAT1", "HAUS1", "HAUS3", "HAUS4", "HAUS5", "HAUS6", "HAX1", "HBS1L", "HCCS", "HCFC1", "HDAC1", "HDAC2", "HDGF", "HDGFL2", "HDGFL3", "HDHD2", "HDHD5", "HDLBP", "HEATR1", "HEATR3", "HEATR6", "HEBP1", "HECTD1", "HECTD3", "HELLS", "HEXA", "HEXB", "HGH1", "HGS", "HIBADH", "HIBCH", "HINT2", "HINT3", "HIRA", "HIRIP3", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLTF", "HM13", "HMBS", "HMCES", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMGCL", "HMGCR", "HMGCS1", "HMGN2", "HMMR", "HMOX1", "HMOX2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPLL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HNRNPUL2", "HOOK2", "HOOK3", "HP1BP3", "HPRT1", "HPS6", "HS2ST1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSD17B7", "HSDL1", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA13", "HSPA14", "HSPA1B", "HSPA2", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPBP1", "HSPD1", "HSPE1", "HSPH1", "HTATSF1", "HTT", "HUWE1", "HYOU1", "IARS", "IARS2", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDH3G", "IDI1", "IFIT5", "IFT27", "IFT81", "IGBP1", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IK", "IKBIP", "IKBKB", "ILF2", "ILF3", "ILK", "ILKAP", "ILVBL", "IMMT", "IMP3", "IMP4", "IMPAD1", "IMPDH1", "IMPDH2", "INA", "INF2", "INPP4A", "INPPL1", "INTS1", "INTS11", "INTS14", "INTS2", "INTS3", "INTS4", "INTS7", "INTS8", "INTS9", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQCB1", "IQGAP1", "IQGAP3", "IRF2BPL", "IRGQ", "IRS4", "ISG20L2", "ISOC1", "IST1", "ISY1", "ISYNA1", "ITCH", "ITGB1", "ITM2C", "ITPA", "ITPK1", "ITSN2", "IVD", "IWS1", "JAGN1", "JMJD6", "JPT2", "JUP", "KARS", "KAT7", "KCTD12", "KDELC2", "KDELR1", "KDM1A", "KDM1B", "KDM2A", "KDM3B", "KDM5A", "KDSR", "KHDRBS1", "KHDRBS3", "KHSRP", "KIAA0319L", "KIAA0368", "KIAA0391", "KIAA1147", "KIAA1468", "KIAA2013", "KIDINS220", "KIF11", "KIF14", "KIF18A", "KIF18B", "KIF1A", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF3A", "KIF4A", "KIF5B", "KIFBP", "KIN", "KLC1", "KLC4", "KLHL11", "KMT2A", "KNOP1", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNA6", "KPNB1", "KRI1", "KRR1", "KTN1", "KYAT3", "L2HGDH", "L3HYPDH", "LACTB", "LAMB1", "LAMC1", "LAMP1", "LAMP2", "LAMTOR1", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LAS1L", "LASP1", "LBR", "LCLAT1", "LDAH", "LDHA", "LDHB", "LDLR", "LEMD3", "LETM1", "LGALS3", "LGALS3BP", "LGMN", "LIG1", "LIG3", "LIMA1", "LIN9", "LIPA", "LLGL1", "LLPH", "LMAN2", "LMAN2L", "LMF2", "LMNA", "LMNB1", "LMNB2", "LNPEP", "LNPK", "LONP1", "LPCAT1", "LPGAT1", "LRBA", "LRP1", "LRPAP1", "LRPPRC", "LRRC1", "LRRC40", "LRRC47", "LRRC57", "LRRC59", "LRRC8C", "LRSAM1", "LRWD1", "LSM12", "LSM14B", "LSM2", "LSM4", "LSM6", "LSM7", "LSS", "LTA4H", "LTN1", "LTV1", "LUC7L", "LUC7L2", "LUC7L3", "LYAR", "LYN", "LYPLA1", "LZTFL1", "M6PR", "MACF1", "MAEA", "MAGED2", "MAGT1", "MAIP1", "MAK16", "MALT1", "MAN2A1", "MAN2B1", "MANF", "MAP1A", "MAP1B", "MAP1S", "MAP4", "MAP7D1", "MAPK1", "MAPK14", "MAPRE1", "MAPRE2", "MARC1", "MARCH5", "MARS", "MARS2", "MAT2A", "MAT2B", "MATR3", "MAU2", "MAVS", "MBD3", "MBOAT7", "MCAM", "MCCC1", "MCCC2", "MCL1", "MCM10", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCMBP", "MCU", "MCUB", "MCUR1", "MDC1", "MDH1", "MDH2", "MDN1", "ME1", "ME2", "MECP2", "MED14", "MED17", "MED22", "MED23", "MED24", "MED4", "MEPCE", "MESD", "METAP1", "METAP2", "METTL13", "METTL3", "METTL7B", "METTL9", "MFN1", "MFN2", "MFSD10", "MFSD3", "MFSD5", "MGEA5", "MGST2", "MGST3", "MIA2", "MIA3", "MICU1", "MIEF1", "MIF", "MIGA1", "MINDY3", "MINPP1", "MIPEP", "MKI67", "MKLN1", "MKRN2", "MLEC", "MMAB", "MMS19", "MOCOS", "MOGS", "MON2", "MORC2", "MORF4L1", "MORF4L2", "MOSPD2", "MOV10", "MPC2", "MPG", "MPHOSPH10", "MPHOSPH6", "MPHOSPH8", "MPI", "MPP1", "MPP2", "MPP6", "MPP7", "MPRIP", "MPST", "MPV17", "MPV17L2", "MRC2", "MRE11", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL14", "MRPL15", "MRPL17", "MRPL19", "MRPL2", "MRPL20", "MRPL21", "MRPL22", "MRPL24", "MRPL28", "MRPL3", "MRPL37", "MRPL38", "MRPL39", "MRPL40", "MRPL41", "MRPL43", "MRPL44", "MRPL45", "MRPL46", "MRPL47", "MRPL48", "MRPL49", "MRPL50", "MRPL53", "MRPL58", "MRPL9", "MRPS11", "MRPS16", "MRPS18A", "MRPS22", "MRPS23", "MRPS25", "MRPS27", "MRPS28", "MRPS30", "MRPS31", "MRPS33", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRPS9", "MRRF", "MRTO4", "MSH2", "MSH3", "MSH6", "MSI1", "MSI2", "MSMO1", "MSN", "MSTO1", "MTA1", "MTA2", "MTAP", "MTBP", "MTCH1", "MTCH2", "MTDH", "MTHFD1", "MTHFD1L", "MTHFD2", "MTHFS", "MTMR14", "MTMR2", "MTMR6", "MTO1", "MTOR", "MTPAP", "MTPN", "MTR", "MTX1", "MTX2", "MTX3", "MUL1", "MUT", "MVD", "MYBBP1A", "MYCBP", "MYCBP2", "MYDGF", "MYEF2", "MYG1", "MYH10", "MYH14", "MYH9", "MYL6", "MYO18A", "MYO1B", "MYO1C", "MYO1D", "MYO6", "NAA10", "NAA15", "NAA25", "NAA35", "NAA40", "NAA50", "NAE1", "NAF1", "NAGLU", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NAPG", "NARS", "NASP", "NAT10", "NAXE", "NBAS", "NBN", "NCAPD2", "NCAPD3", "NCAPG", "NCAPG2", "NCAPH", "NCBP1", "NCBP3", "NCDN", "NCEH1", "NCKAP1", "NCKIPSD", "NCL", "NCLN", "NCOA5", "NCOR1", "NCSTN", "ND1", "NDC1", "NDC80", "NDRG3", "NDUFA10", "NDUFA11", "NDUFA13", "NDUFA4", "NDUFA5", "NDUFA7", "NDUFA8", "NDUFA9", "NDUFAF2", "NDUFAF3", "NDUFAF4", "NDUFAF7", "NDUFB10", "NDUFB3", "NDUFB4", "NDUFB5", "NDUFB6", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS6", "NDUFS7", "NDUFS8", "NDUFV1", "NDUFV2", "NECAP2", "NEDD1", "NEDD4L", "NEFL", "NEFM", "NEK9", "NELFA", "NELFB", "NELFCD", "NELFE", "NEMF", "NENF", "NES", "NF1", "NFATC2IP", "NFKBIL1", "NFS1", "NFU1", "NFXL1", "NHLRC2", "NHP2", "NIFK", "NIP7", "NIPBL", "NIPSNAP1", "NIPSNAP2", "NISCH", "NIT2", "NKRF", "NKTR", "NLE1", "NLN", "NLRX1", "NME1", "NME2", "NMT1", "NNT", "NOA1", "NOB1", "NOC2L", "NOC3L", "NOC4L", "NOL10", "NOL11", "NOL6", "NOL7", "NOL8", "NOL9", "NOLC1", "NOM1", "NONO", "NOP14", "NOP16", "NOP2", "NOP53", "NOP56", "NOP58", "NOP9", "NOSIP", "NOTCH2", "NPC1", "NPC2", "NPEPPS", "NPLOC4", "NPM1", "NRBP1", "NRDC", "NRDE2", "NRP1", "NSA2", "NSD1", "NSD2", "NSD3", "NSDHL", "NSF", "NSMCE2", "NSUN2", "NT5C2", "NT5C3A", "NT5C3B", "NT5DC1", "NT5DC2", "NTHL1", "NTMT1", "NTPCR", "NUB1", "NUBP2", "NUBPL", "NUCB1", "NUCB2", "NUCKS1", "NUDC", "NUDCD1", "NUDCD2", "NUDCD3", "NUDT1", "NUDT16L1", "NUDT21", "NUDT5", "NUF2", "NUFIP2", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP160", "NUP188", "NUP205", "NUP210", "NUP214", "NUP35", "NUP37", "NUP43", "NUP50", "NUP54", "NUP58", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NUPL2", "NUSAP1", "NUTF2", "NVL", "NXF1", "NXN", "OARD1", "OAT", "OCIAD1", "OCLN", "OCRL", "ODR4", "OGDH", "OGFOD3", "OGT", "OLA1", "OPA1", "OPA3", "ORC2", "ORC3", "ORC5", "OSBP", "OSBPL11", "OSBPL1A", "OSBPL6", "OSBPL8", "OSBPL9", "OSGEP", "OSTF1", "OTUB1", "OXA1L", "OXSR1", "P3H1", "P3H4", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PAF1", "PAFAH1B1", "PAFAH1B2", "PAFAH1B3", "PAICS", "PAK1IP1", "PAK2", "PALD1", "PALLD", "PANK4", "PAPOLA", "PAPSS1", "PARD3", "PARG", "PARK7", "PARN", "PARP1", "PARP2", "PATL1", "PBDC1", "PBK", "PBRM1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCM1", "PCMT1", "PCNA", "PCYOX1", "PDAP1", "PDCD11", "PDCD5", "PDCD6", "PDCD6IP", "PDCL3", "PDE12", "PDHA1", "PDHB", "PDHX", "PDIA3", "PDIA4", "PDIA6", "PDK1", "PDK3", "PDLIM1", "PDLIM5", "PDP1", "PDS5A", "PDS5B", "PDSS2", "PDXDC1", "PDZD8", "PEBP1", "PECR", "PEF1", "PELO", "PELP1", "PEPD", "PES1", "PEX11B", "PEX14", "PEX19", "PEX3", "PFAS", "PFDN2", "PFDN4", "PFDN5", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGM3", "PGP", "PGRMC1", "PGRMC2", "PHB", "PHB2", "PHF10", "PHF2", "PHF3", "PHF5A", "PHF6", "PHGDH", "PHIP", "PHKA1", "PHKB", "PI4K2A", "PI4KA", "PI4KB", "PICALM", "PIGG", "PIGK", "PIGS", "PIGT", "PIGU", "PIH1D1", "PIK3C2A", "PIK3R2", "PIK3R4", "PIN1", "PIN4", "PINX1", "PIP4K2C", "PIR", "PISD", "PITHD1", "PITPNA", "PITPNB", "PITRM1", "PKM", "PKMYT1", "PKN1", "PKN2", "PLA2G15", "PLAA", "PLBD2", "PLCG1", "PLD3", "PLD6", "PLEC", "PLEKHA5", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLRG1", "PLS3", "PLXNB2", "PM20D2", "PMPCA", "PMPCB", "PMVK", "PNKP", "PNN", "PNO1", "PNP", "PNPLA6", "PNPLA8", "PNPT1", "POFUT1", "POGZ", "POLA1", "POLA2", "POLD1", "POLD2", "POLDIP2", "POLDIP3", "POLE", "POLE2", "POLG", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2A", "POLR2B", "POLR2C", "POLR2D", "POLR2E", "POLR2G", "POLR2L", "POLR3A", "POLR3B", "POLR3C", "POLRMT", "PON2", "POP1", "POP4", "POR", "PPA1", "PPA2", "PPAN", "PPAT", "PPCDC", "PPFIA1", "PPHLN1", "PPIB", "PPIC", "PPID", "PPIE", "PPIF", "PPIG", "PPIH", "PPIL4", "PPM1G", "PPME1", "PPOX", "PPP1CA", "PPP1CB", "PPP1R10", "PPP1R7", "PPP1R8", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP2R5E", "PPP3CA", "PPP4R1", "PPP4R3A", "PPP5C", "PPP6C", "PPP6R3", "PPT1", "PPWD1", "PQBP1", "PRAF2", "PRC1", "PRCC", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PREP", "PREPL", "PRIM1", "PRIM2", "PRKAA1", "PRKAA2", "PRKACA", "PRKAG1", "PRKAR1A", "PRKAR2A", "PRKCB", "PRKCSH", "PRKDC", "PRMT1", "PRMT3", "PRMT5", "PRMT9", "PRPF19", "PRPF3", "PRPF31", "PRPF38B", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPS2", "PRPSAP1", "PRPSAP2", "PRRC1", "PRRC2A", "PRRC2B", "PRRC2C", "PSAP", "PSAT1", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD6", "PSMD7", "PSMD8", "PSME1", "PSME2", "PSME3", "PSME4", "PSMG1", "PSMG2", "PSMG3", "PSPC1", "PTBP1", "PTBP2", "PTCD1", "PTCD3", "PTDSS1", "PTDSS2", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK2", "PTK7", "PTPA", "PTPN1", "PTPN11", "PTPN23", "PTPRF", "PTRH2", "PUF60", "PUM3", "PURA", "PUS1", "PUS7", "PUS7L", "PWP1", "PWP2", "PXMP2", "PXN", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QDPR", "QKI", "QRSL1", "QSOX2", "QTRT2", "R3HCC1", "RAB10", "RAB12", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB1B", "RAB23", "RAB24", "RAB2A", "RAB34", "RAB35", "RAB3B", "RAB3GAP1", "RAB3GAP2", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RAB8A", "RAB9A", "RABEPK", "RABGAP1", "RABGGTA", "RABL3", "RABL6", "RAC1", "RACGAP1", "RACK1", "RAD18", "RAD21", "RAD23A", "RAD23B", "RAD50", "RAD54L2", "RAE1", "RAI14", "RALA", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP6", "RANBP9", "RANGAP1", "RAP1GDS1", "RAPGEF2", "RARS", "RARS2", "RAVER1", "RBBP4", "RBBP5", "RBBP6", "RBBP7", "RBM10", "RBM12", "RBM12B", "RBM14", "RBM17", "RBM19", "RBM22", "RBM25", "RBM26", "RBM27", "RBM28", "RBM3", "RBM34", "RBM39", "RBM4", "RBM45", "RBM47", "RBM5", "RBM6", "RBM8A", "RBMX", "RBMXL1", "RBPJ", "RCC1", "RCC2", "RCL1", "RCN1", "RCN2", "RDH11", "RDH13", "RDH14", "RDX", "RECQL", "REEP4", "REEP5", "RER1", "RETSAT", "REXO2", "REXO4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RFT1", "RHBDD2", "RHEB", "RHOG", "RHOT1", "RHOT2", "RIDA", "RIF1", "RINT1", "RIPK1", "RMDN1", "RMDN3", "RNASEH2A", "RNASET2", "RNF2", "RNF20", "RNF40", "RNMT", "RNPEP", "RNPS1", "ROBO1", "ROCK1", "ROCK2", "RP2", "RPA1", "RPA2", "RPAP1", "RPAP3", "RPF1", "RPF2", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPN1", "RPN2", "RPP30", "RPP38", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS26", "RPS28", "RPS29", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RPTOR", "RPUSD3", "RRAS2", "RRBP1", "RREB1", "RRM1", "RRM2", "RRP1", "RRP12", "RRP15", "RRP1B", "RRP36", "RRP8", "RRP9", "RRS1", "RSBN1", "RSF1", "RSL1D1", "RSL24D1", "RSPRY1", "RSU1", "RTCA", "RTCB", "RTFDC1", "RTN1", "RTN2", "RTN3", "RTN4", "RTN4IP1", "RTRAF", "RUFY1", "RUVBL1", "RUVBL2", "S100A11", "S100A13", "SAAL1", "SACM1L", "SAE1", "SAFB", "SAFB2", "SALL2", "SAMD4B", "SAMHD1", "SAMM50", "SAP130", "SAP18", "SAP30BP", "SAR1A", "SAR1B", "SARM1", "SARNP", "SARS", "SARS2", "SART1", "SART3", "SBDS", "SBNO1", "SCAF1", "SCAF11", "SCAF4", "SCAMP1", "SCAMP2", "SCAMP3", "SCAMP4", "SCARB1", "SCARB2", "SCCPDH", "SCD", "SCFD1", "SCFD2", "SCML2", "SCO1", "SCO2", "SCP2", "SCPEP1", "SCRIB", "SCRN1", "SCYL1", "SDAD1", "SDF4", "SDHA", "SDHB", "SDHC", "SDR39U1", "SEC11A", "SEC16A", "SEC22B", "SEC23A", "SEC23B", "SEC23IP", "SEC24A", "SEC24B", "SEC24C", "SEC31A", "SEC61A1", "SEC61B", "SEC62", "SEC63", "SEH1L", "SEL1L", "SENP3", "SEPT11", "SEPT2", "SEPT7", "SEPT9", "SERBP1", "SERPINB6", "SERPINH1", "SET", "SETD1A", "SETD2", "SETD3", "SETDB1", "SEZ6L2", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFSWAP", "SFXN1", "SFXN2", "SFXN4", "SGF29", "SGPL1", "SGTA", "SH3GL1", "SH3GLB1", "SHCBP1", "SHMT1", "SHMT2", "SHTN1", "SIGMAR1", "SIN3A", "SKA1", "SKA3", "SKIV2L", "SKIV2L2", "SKP1", "SKP2", "SLC12A2", "SLC12A9", "SLC16A1", "SLC19A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A16", "SLC25A17", "SLC25A19", "SLC25A20", "SLC25A21", "SLC25A24", "SLC25A25", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A33", "SLC25A4", "SLC25A44", "SLC25A5", "SLC25A6", "SLC27A4", "SLC33A1", "SLC35A4", "SLC35B2", "SLC35F2", "SLC39A14", "SLC3A2", "SLC4A1AP", "SLC4A2", "SLC5A6", "SLC7A1", "SLC9A3R1", "SLFN11", "SLIRP", "SLIT2", "SLK", "SLMAP", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC5", "SMC6", "SMCHD1", "SMG1", "SMG5", "SMN1*", "SMNDC1", "SMPD4", "SMS", "SMU1", "SND1", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPC", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNU13", "SNW1", "SNX1", "SNX17", "SNX19", "SNX2", "SNX27", "SNX3", "SNX5", "SNX6", "SNX9", "SOAT1", "SOD2", "SON", "SORD", "SORT1", "SPAG5", "SPAG9", "SPART", "SPATA5", "SPATA5L1", "SPATS2L", "SPC25", "SPCS2", "SPCS3", "SPDL1", "SPECC1L", "SPEN", "SPNS1", "SPOUT1", "SPPL2A", "SPR", "SPRYD4", "SPTAN1", "SPTBN1", "SPTLC1", "SPTLC2", "SQLE", "SRC", "SRCAP", "SREK1", "SRI", "SRM", "SRP14", "SRP54", "SRP68", "SRP72", "SRP9", "SRPK1", "SRPK2", "SRPRA", "SRPRB", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF3", "SRSF4", "SRSF5", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSR1", "SSR4", "SSRP1", "STAG1", "STAG2", "STAM", "STAM2", "STAT1", "STAT3", "STAU1", "STAU2", "STIP1", "STK26", "STK3", "STK4", "STMN1", "STOM", "STOML2", "STRAP", "STRBP", "STRIP1", "STRN", "STT3A", "STT3B", "STUB1", "STX10", "STX12", "STX16", "STX18", "STX4", "STX7", "STX8", "STXBP2", "STXBP3", "STXBP4", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGP2", "SUGT1", "SUN1", "SUN2", "SUPT16H", "SUPT3H", "SUPT5H", "SUPT6H", "SUPV3L1", "SURF6", "SUZ12", "SV2A", "SYAP1", "SYMPK", "SYNCRIP", "SYNE1", "SYNE2", "SYNGR2", "SYNJ2BP", "SYS1", "TAB1", "TACC3", "TAF15", "TAF6", "TAGLN2", "TALDO1", "TAMM41", "TAP1", "TAP2", "TARBP1", "TARDBP", "TARS", "TARS2", "TARSL2", "TBC1D13", "TBC1D15", "TBC1D4", "TBC1D9B", "TBCA", "TBCB", "TBCD", "TBCE", "TBL1XR1", "TBL2", "TBL3", "TBRG4", "TCAF1", "TCEA1", "TCERG1", "TCOF1", "TCP1", "TCP11L1", "TDRKH", "TECR", "TEFM", "TELO2", "TERF2IP", "TES", "TEX10", "TEX264", "TFAM", "TFB1M", "TFCP2", "TFG", "TFIP11", "TFRC", "TGFBRAP1", "TGOLN2", "THADA", "THAP11", "THEM6", "THOC1", "THOC2", "THOC3", "THOC5", "THOC6", "THOP1", "THRAP3", "THUMPD1", "THYN1", "TIA1", "TIAL1", "TIGAR", "TIMM10B", "TIMM17B", "TIMM23", "TIMM44", "TIMM50", "TIMM8B", "TJP1", "TJP2", "TK1", "TKT", "TLCD1", "TLE3", "TLK2", "TLN1", "TM9SF2", "TM9SF3", "TM9SF4", "TMA16", "TMCO1", "TMED10", "TMED2", "TMED7", "TMED9", "TMEM109", "TMEM11", "TMEM115", "TMEM126A", "TMEM14C", "TMEM161A", "TMEM167A", "TMEM19", "TMEM192", "TMEM199", "TMEM201", "TMEM205", "TMEM214", "TMEM230", "TMEM259", "TMEM33", "TMEM43", "TMEM65", "TMEM87A", "TMEM97", "TMLHE", "TMOD3", "TMPO", "TMPO", "TMPPE", "TMTC3", "TMX1", "TMX2", "TMX3", "TNKS1BP1", "TNPO1", "TNPO2", "TNPO3", "TOE1", "TOMM20", "TOMM22", "TOMM34", "TOMM40", "TOMM5", "TOMM70", "TOP1", "TOP2A", "TOP2B", "TOPBP1", "TOR1A", "TOR1AIP1", "TOR1AIP2", "TOR1B", "TOX4", "TP53", "TP53BP1", "TP53BP2", "TPBG", "TPD52", "TPD52L2", "TPI1", "TPM3", "TPM4", "TPP1", "TPP2", "TPR", "TPT1", "TPX2", "TRA2A", "TRA2B", "TRABD", "TRAF2", "TRAP1", "TRAPPC11", "TRAPPC4", "TRAPPC5", "TRIM13", "TRIM21", "TRIM25", "TRIM26", "TRIM27", "TRIM28", "TRIM33", "TRIM4", "TRIO", "TRIP12", "TRIP13", "TRIP4", "TRIR", "TRMT1", "TRMT10C", "TRMT11", "TRMT1L", "TRMT2A", "TRMT6", "TRMU", "TROVE2", "TRRAP", "TRUB1", "TSFM", "TSG101", "TSN", "TSNAX", "TSPAN3", "TSPAN6", "TSPO", "TSR1", "TST", "TTC1", "TTC19", "TTC26", "TTC27", "TTC28", "TTC37", "TTC38", "TTC4", "TTF2", "TTK", "TTLL12", "TTYH3", "TUBB", "TUBB2A", "TUBB2B", "TUBB3", "TUBB4A", "TUBB6", "TUBGCP2", "TUBGCP3", "TUFM", "TWF2", "TWNK", "TXLNA", "TXLNG", "TXNDC12", "TXNDC15", "TXNDC17", "TXNDC5", "TXNDC9", "TXNL1", "TXNRD1", "TYMS", "U2AF1", "U2AF2", "U2SURP", "UAP1", "UBA1", "UBA2", "UBA3", "UBA6", "UBAC1", "UBAP2L", "UBE2J1", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2O", "UBE2S", "UBE3A", "UBE3C", "UBE4A", "UBFD1", "UBLCP1", "UBQLN4", "UBR2", "UBR4", "UBR5", "UBTF", "UBXN1", "UBXN4", "UBXN7", "UCHL5", "UCK2", "UFC1", "UFD1", "UFL1", "UFM1", "UGCG", "UGDH", "UGGT1", "UGP2", "UGT8", "UHRF1", "UMPS", "UNC45A", "UPF1", "UPF2", "UPF3B", "UQCC2", "UQCR10", "UQCRB", "UQCRC1", "UQCRC2", "UQCRFS1", "UQCRQ", "URB1", "URGCP", "UROD", "USMG5", "USO1", "USP10", "USP11", "USP14", "USP19", "USP24", "USP28", "USP36", "USP39", "USP47", "USP48", "USP5", "USP7", "USP9X", "UTP11", "UTP14A", "UTP15", "UTP18", "UTP20", "UTP3", "UTP4", "UTP6", "UTRN", "VAMP7", "VANGL1", "VANGL2", "VAPA", "VAPB", "VARS1", "VARS2", "VAT1", "VBP1", "VCL", "VCP", "VDAC1", "VDAC2", "VDAC3", "VIM", "VIPAS39", "VIRMA", "VPS13A", "VPS13C", "VPS16", "VPS18", "VPS26A", "VPS29", "VPS33A", "VPS33B", "VPS35", "VPS37B", "VPS45", "VPS4A", "VPS4B", "VPS50", "VPS51", "VPS52", "VPS53", "VRK1", "VRK3", "VTA1", "WAPL", "WARS", "WASHC4", "WASHC5", "WBP11", "WBP2", "WDHD1", "WDR1", "WDR11", "WDR12", "WDR18", "WDR26", "WDR3", "WDR33", "WDR36", "WDR4", "WDR41", "WDR43", "WDR46", "WDR5", "WDR6", "WDR61", "WDR7", "WDR73", "WDR74", "WDR75", "WDR77", "WDR82", "WDR91", "WFS1", "WIPI2", "WIZ", "WLS", "WRAP73", "WRNIP1", "WTAP", "XAB2", "XPNPEP1", "XPNPEP3", "XPO1", "XPO4", "XPO5", "XPO7", "XPOT", "XRCC1", "XRCC5", "XRCC6", "XRN2", "XXYLT1", "YARS", "YARS2", "YEATS2", "YEATS4", "YIF1A", "YKT6", "YLPM1", "YME1L1", "YOD1", "YTHDC1", "YTHDC2", "YTHDF2", "YTHDF3", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2", "ZC3H11A", "ZC3H14", "ZC3H15", "ZC3H18", "ZC3H4", "ZC3H7A", "ZC3HAV1", "ZCCHC11", "ZCCHC3", "ZCCHC8", "ZFR", "ZFYVE16", "ZMPSTE24", "ZMYM2", "ZMYM4", "ZNF281", "ZNF318", "ZNF326", 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5.273634836180541e-06 0.0002008886603826 2.4490692503129386e-05 0.0006279861154086 9.21792674980943e-07 +Cholesterol metabolism 12 27 2.576307840061786 0.0099861694962042 7.111650485436893 23.79854368932039 1.169709264926864 0.2871268807807383 2.8890755390042298 2.7173834172675666 1.205315163774447 0.3061468445376054 1.036422750342335e-05 0.1952735388158895 0.0008840144918394 9.936897298788151e-07 9.950941556486035e-07 +Calcium transport 8 10 2.513142787037641 0.0119660892103554 3.7305825242718447 8.240291262135923 0.5020754788348019 0.3462849026834517 2.2148520410126937 1.861210565609195 1.3394131933179945 0.3209721672484884 0.0629956136787357 1.0 0.3009165941166509 0.224257489169728 0.0319540971359957 +Sterol metabolism 12 29 2.4106859447866005 0.0159225525480746 7.606796116504855 25.203883495145632 1.1785484151208083 0.2872927387372206 3.1377365577760563 3.096691699470945 1.2399567569518877 0.3064799172119154 1.9036835092664743e-05 0.2068720246529641 0.0011293669878184 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O14949,Q9P0J0,Q9UDW1,P22695,P03886,O43169,O43676,O95139,P08574,Q96CU9,P00403,Q99643,Q86Y39,Q16134,O95168,O95299,O96000,Q9Y6M9,P21912,Q9H3N1,P51970,O75306 22 +Respiratory chain 0.5962742820924081 2.5855646649635835 0.0097219634502703 0.8136929590983953 0.1638388823013448 33 O14949,Q9P0J0,P22695,Q96CU9,O95168,P00403,O95299,O96000,Q9UDW1,P51970,Q86Y39,Q9Y6M9,P03886,O43676,O95139 15 +Cholesterol metabolism 0.6091139266100357 2.576307840061786 0.0099861694962042 0.8220503988128268 0.1638388823013448 27 Q15392,P37268,O94905,P61916,P04062,P04035,Q15800,Q16850,Q15125,Q9UBM7,Q14739,O15118 12 +Calcium transport 0.7703004123442938 2.513142787037641 0.0119660892103554 0.8738874574450779 0.1638388823013448 10 Q96AQ8,P98194,P23634,P20020,Q9UM00,Q9BPX6,P16615,O95202 8 +Sterol metabolism 0.5818731236853217 2.4106859447866005 0.0159225525480746 0.9367535741913886 0.1726426042661013 29 Q15392,P37268,O94905,P61916,P04062,P04035,Q15800,Q16850,Q15125,Q9UBM7,Q14739,O15118 12 +Antiport 0.7992853710401155 2.4075542233020686 0.0160597771410326 0.9382525660119828 0.1726426042661013 8 P12236,P04920,P12235,P51798,P51790,O95202 6 +Cholesterol biosynthesis 0.6224228972857664 2.250127327660975 0.0244408637965349 0.985821859252194 0.2001823130001913 17 Q15392,P37268,P04035,Q15800,Q16850,Q15125,Q9UBM7,Q14739 8 +Steroid metabolism 0.5554386515570965 2.230107823223636 0.0257402855866664 0.9887265688390932 0.2012422327684828 30 Q15392,P37268,O94905,P61916,P04062,P04035,Q15800,Q16850,Q15125,Q9UBM7,Q14739,O15118 12 +Hydrogen ion transport 0.5921231690350013 2.1603152051939714 0.0307482766688671 0.9953538622764172 0.2299436342193543 19 P06576,Q93050,P24539,Q15904,Q9Y487,O75964 6 +Steroid biosynthesis 0.5510903154367763 2.135717146120863 0.0327024759788536 0.9967165297016346 0.234367744515118 25 Q15392,P37268,Q53GQ0,P04035,Q15800,Q16850,Q15125,P14324,Q9UBM7,Q14739 10 +Sterol biosynthesis 0.5817141819720212 2.0912883043632995 0.0365022276029749 0.9983315124753994 0.2414762749119881 19 Q15392,P37268,P04035,Q15800,Q16850,Q15125,Q9UBM7,Q14739 8 +ER-Golgi transport 0.4767179340636683 1.9793445372433132 0.0477772284058894 0.9997796906933916 0.2904868654127029 48 O15498,Q15363,Q9NR31,Q9Y296,Q9P2W9,O95070,O95197,P24390,Q9HCU5,O95249,Q12981,Q99747,Q9Y282,Q5JRA6,P62820,P49755,P51572,O75396,Q969X5 19 +Potassium transport 0.8051664338828948 1.968788037075825 0.0489774366102813 0.9998226540849172 0.2904868654127029 5 P05023,P55011,Q9NUT2 3 +Translocation 0.4759129586442468 1.941933434625512 0.0521451591850401 0.999900093170591 0.2932000703105952 47 O60830,O14925,P41208,Q9BTX1,Q8NFH5,Q9Y5J9,Q99442,Q8TD16,Q9NS69,O43615,O75381,Q8NFH4,Q53GS7,Q7Z3B4,Q3ZCQ8,Q99567,Q9Y5J6 17 +Vision 0.7945487555719511 1.922452457861973 0.0545488502903432 0.9999354458421216 0.2932000703105952 5 Q6P4Q7,P50897,Q9H6K4 3 +Sensory transduction 0.794548755571951 1.922452457861973 0.0545488502903432 0.9999354458421216 0.2932000703105952 5 Q6P4Q7,P50897,Q9H6K4 3 +Sodium transport 0.7911135438701679 1.9074150321679268 0.0564668643190711 0.9999544769929812 0.2943121412994009 5 P05023,P55011,P54709 3 +Lipid biosynthesis 0.4124451775896613 1.7939466087910971 0.0728216911186765 0.9999977505247902 0.3358071136334331 60 Q15392,P35790,Q96N66,Q96G23,Q15800,Q9NZ01,Q92604,O95674,Q9P035,Q9NUQ2,Q9H7Z7,P48651,Q16850,Q9BVG9,Q9UBM7,Q16739,Q53GQ0,Q15125,Q14739,Q9UG56,P37268,Q9HCL2,P38398,O00116,P04035,Q8NF37 26 +GPI-anchor biosynthesis 0.7080078233119288 1.691044981629554 0.0908282119166365 0.9999999228912676 0.3810354256014998 6 Q96S52,Q5H8A4,Q92643 3 +ATP synthesis 0.6730195949883295 1.6481397724513431 0.0993239924108955 0.99999998466096 0.4067553974922387 7 P06576,O75964 2 +Apoptosis 0.4204449040298985 1.5309985054474342 0.1257697620253053 0.999999999908874 0.4807199792967225 115 Q9P0J0,O60313,P46379,Q14728,P61289,Q07820,Q9UHX1,O95197,P09601,P05067,P21796,Q96A26,O14737,Q12981,O95470,Q6NUQ4,O95831,Q9H3K2,Q9Y371,Q969V5,Q15041,O14681,Q99828,P12236,P04637,P51572,Q9NZJ7,Q96KA5 28 +Amino-acid transport 0.6448045224601027 1.5075376946452166 0.1316728893832879 0.9999999999715856 0.4840318300200359 7 P30825,Q96H78,Q6P4A7 3 +Autophagy 0.4501556006470724 1.4245147170216246 0.1542975279161267 0.999999999999697 0.5160906229561039 32 Q969Q5,O95140,Q9Y6I9,Q9Y371,Q9NRR5,Q7Z3C6,P13473,Q6UWE0,O14681,Q5T8D3 10 +Notch signaling pathway 0.6029950088463059 1.4185597836043795 0.1560273976378918 0.999999999999787 0.5160906229561039 8 Q9UBV2,Q92542 2 +Adaptive immunity 0.4940723192653952 1.367103754002119 0.1715927867888134 0.9999999999999912 0.5340750207761268 16 Q03519,Q6P179,Q9NZ08,Q03518,P10321 5 +Copper transport 0.9015222118670334 1.3598263227276226 0.1738848904852505 0.9999999999999948 0.5340750207761268 2 P35670 1 +Lipid transport 0.4385819065097816 1.2756140205917756 0.2020919953862252 1.0 0.560642309781141 25 Q99720,Q9H2V7,O15118,Q9BUR5 4 +Peroxisome biogenesis 0.7322805959865476 1.229522347434359 0.2188760243539071 1.0 0.5683736582562638 4 P40855 1 +Leukotriene biosynthesis 0.8670394532463483 1.2193006728059987 0.2227300933671872 1.0 0.5683736582562638 2 Q99735 1 +Peptide transport 0.8570984777881325 1.1790141223922466 0.2383925524055237 1.0 0.5827005419413774 2 Q03519 1 +Lipid metabolism 0.4055370708779104 1.1206681588909573 0.2624291405268697 1.0 0.5939185811923894 137 Q15392,P35790,Q9H6V9,Q96N66,Q96G23,O15269,Q15800,Q9UKU0,P40939,Q9NZ01,Q16836,Q92604,O95674,P07602,P17900,Q8N2A8,Q8NHP8,Q9P035,P09960,Q13510,Q9NUQ2,P51648,Q9H7Z7,P50416,Q16850,O95470,Q9BVG9,P48651,Q9UBM7,O15118,Q16739,Q53GQ0,P04062,Q16880,P61916,Q8NCG7,Q15125,P23786,Q14739,Q99735,Q9UG56,P37268,Q9HCL2,O94905,Q9NPH0,P38398,P04035,O00116,O15254,A1L0T0,Q06136,Q8NF37 52 +Unfolded protein response 0.5228775536867631 1.106915976761303 0.2683302576117259 1.0 0.5985279985673958 9 O95140,Q9GZP9,Q9BUN8 3 +Heme biosynthesis 0.5786608279090539 1.067449242228856 0.2857690224731941 1.0 0.5985279985673958 6 P22830 1 +Sodium/potassium transport 0.7971772163023694 0.9907669640814412 0.321799384101489 1.0 0.5985279985673958 3 P05023 1 +Sugar transport 0.8049083566324862 0.9703498989316296 0.3318721127459711 1.0 0.5985279985673958 2 Q96AA3 1 +Chemotaxis 0.5503731343283517 0.8177885605461191 0.4134779311791696 1.0 0.6370961122259539 5 Q8NHP6,P09429,O94813,Q9Y6N7 4 +Symport 0.5456717372451638 0.7966467943585561 0.4256561923790356 1.0 0.6385812791029988 5 P53985,P55011,Q9Y289 3 +Ubiquinone biosynthesis 0.7423865755127091 0.7875702290610997 0.4309481342990999 1.0 0.6389920612021137 3 Q86YH6,O75208 2 +Transport 0.4837193673966647 0.7513776990030832 0.4524253800697209 1.0 0.6539257594285042 511 O14949,Q9BSK2,Q86Y82,O15498,Q8N4H5,Q9C0H2,P05141,Q9NR31,Q9H2D1,Q9NS69,Q9P2W9,Q9UDW1,P20020,P55011,Q4KMQ2,O15127,P03886,Q9UM00,O43169,Q8TDW0,O43676,Q5T8D3,O60830,O95070,O95197,P61026,Q9NRK6,P24390,P24539,P08574,P45880,Q13505,Q96ED9,P23634,Q99643,P21796,Q86Y39,O95249,Q6P4A7,P35670,O15118,O95202,Q9Y282,P62820,Q16134,O60499,Q70HW3,Q9Y277,Q99442,P30825,A0AVF1,O75964,Q9Y6M9,Q99720,Q9UNH7,P54709,Q8N5M9,Q93050,Q9H9B4,Q9UBX3,O75396,Q9HD20,Q9NZJ7,Q9BUR5,O00461,O43808,Q969X5,Q9Y487,P31751,P16260,O75306,Q3ZCQ8,Q9Y6M1,O14828,Q96FV9,O00400,Q8NE86,Q15363,Q9Y289,Q96HE7,Q8N2H4,Q7Z3B4,Q99567,Q9Y3B3,P16615,Q96P70,Q99584,P41208,P28288,Q9Y5J9,Q9UGP8,Q96CU9,Q8TB61,Q9BZF3,Q9UNK0,Q9HCU5,Q12768,Q7L5D6,P51798,Q9Y5J6,Q6KCM7,Q99747,Q969Q5,Q9NZD2,Q9H9H4,Q92973,P61421,P61019,P53985,Q9BQT8,Q8TEX9,Q15043,Q9Y3E0,Q92543,P51790,O60831,Q9UJS0,P51572,Q9H3N1,Q96S66,O75381,Q9Y619,Q9P0J0,O43681,Q96AA3,P05023,P22695,Q96RL7,O14925,P98194,Q6NUK1,Q96H78,P00403,Q96ES6,Q9BTX1,Q9H2V7,Q12981,O60749,Q04656,Q5JRA6,P0CG08,O95168,P61916,Q6P4Q7,Q7Z3C6,O75431,P23786,Q96L92,Q9BVK6,P12236,Q567U6,P49755,Q15904,Q9NUT2,Q9NP58,Q7L0J3,P12235,Q96AQ8,O00203,P06576,Q9HC21,P46379,P56385,Q14728,Q9Y296,O43615,P53007,Q6UWE0,Q9Y6C9,Q9Y5X3,O95139,Q03519,Q9BUN8,Q9C0E2,P50416,O96008,Q8NE01,P52292,Q15388,Q8TD16,Q03518,O95299,O96000,Q8NFH4,Q9BPX6,P21912,Q8NFH5,O75746,P04920,P51970 190 +Glycogen biosynthesis 0.5541087818423778 0.5173480042490196 0.6049132493449108 1.0 0.7594531305644135 4 P35573 1 +Phagocytosis 0.5643256681168554 0.2354753551917009 0.8138398048335347 1.0 0.9458138272389728 3 P20339,P50570 2 +Spermatogenesis 0.3009014374669453 0.1809865765117427 0.8563781124085312 1.0 0.95103796085423 26 O94901,P46379,Q8N2A8,Q9Y2W6,Q99598,Q15645,Q99828 7 +Tyrosine catabolism 0.536191363777568 0.1527863885128234 0.8785667320952086 1.0 0.9564144172175688 2 O43708 1 +Phenylalanine catabolism 0.536191363777568 0.1527863885128234 0.8785667320952086 1.0 0.9564144172175688 2 O43708 1 +Immunity 0.2704157424927103 0.0903383802132947 0.9280183218229554 1.0 0.9914233003325984 85 Q9BQ95,Q6P179,Q03519,P46379,P23246,Q9NZ08,Q8WXF1,Q03518,P10321,O00584,Q14166,Q8IV08,Q86UT6,Q9NUD5,O60858,Q8N5M9 16 +Methionine biosynthesis 0.4815159987573714 0.0828885334747628 0.9339401716265636 1.0 0.9915907995047466 2 Q99707 1 +Angiogenesis 0.3067057655380965 0.05051445842168 0.9597124279597042 1.0 1.0 12 P35613 1 +Proline biosynthesis 0.4151646985705504 0.0182929378804723 0.985405161280299 1.0 1.0 3 Q96C36,P54886 2 +Protein transport 0.3941221990109815 0.0048051649840735 0.99616604780118 1.0 1.0 260 Q86Y82,O15498,Q15363,Q8N4H5,Q9NR31,Q9NS69,Q9P2W9,Q8N2H4,O43615,O15127,Q7Z3B4,Q6UWE0,Q99567,Q9Y3B3,Q9Y5X3,Q96P70,Q96RL7,P61026,O95070,O60830,Q99584,P41208,O14925,Q03519,Q9BUN8,P24390,Q9Y5J9,Q9UGP8,Q13505,Q96ED9,Q9C0E2,Q9HCU5,Q12768,O95249,Q9BTX1,O96008,Q99747,Q9Y5J6,O60749,Q969Q5,Q5JRA6,Q9H9H4,P62820,Q92973,O60499,P0CG08,P52292,Q15388,Q8TEX9,Q99442,Q8TD16,Q03518,A0AVF1,Q9Y3E0,Q7Z3C6,Q8NFH4,Q9UNH7,O75431,Q92543,Q96L92,Q8N5M9,Q9BVK6,O60831,Q567U6,Q8NFH5,P49755,P51572,O75396,Q9HD20,Q3ZCQ8,O75381,O14828,O00203 73 diff --git a/protein_atlas_biological_process/selections.json b/protein_atlas_biological_process/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..cf5b933912c02c9d059acec7d7d8c5a0d65a8518 --- /dev/null +++ b/protein_atlas_biological_process/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["ATP synthesis", "Adaptive immunity", "Amino-acid biosynthesis", "Amino-acid transport", "Angiogenesis", "Anion exchange", "Antiport", "Antiviral defense", "Apoptosis", "Arginine metabolism", "Aromatic hydrocarbons catabolism", "Asparagine biosynthesis", "Autophagy", "B-cell activation", "Behavior", "Biological rhythms", "Biomineralization", "Branched-chain amino acid catabolism", "Calcium transport", "Carbohydrate metabolism", "Carnitine biosynthesis", "Catecholamine metabolism", "Cell adhesion", "Cell cycle", "Cell division", "Cell shape", "Chemotaxis", "Cholesterol biosynthesis", "Cholesterol metabolism", "Chromosome partition", "Cilium biogenesis/degradation", "Coenzyme A biosynthesis", "Collagen degradation", "Complement pathway", "Copper transport", "DNA condensation", "DNA damage", "DNA excision", "DNA recombination", "DNA repair", "DNA replication", "DNA synthesis", "Detoxification", "Differentiation", "ER-Golgi transport", "Electron transport", "Endocytosis", "Erythrocyte maturation", "Exocytosis", "Fatty acid biosynthesis", "Fatty acid metabolism", "Fertilization", "Fucose metabolism", "GMP biosynthesis", "GPI-anchor biosynthesis", "Galactose metabolism", "Gastrulation", "Gluconate utilization", "Gluconeogenesis", "Glucose metabolism", "Glutathione biosynthesis", "Glycogen biosynthesis", "Glycogen metabolism", "Glycolysis", "Glyoxylate bypass", "Growth arrest", "Growth regulation", "Hearing", "Heme biosynthesis", "Host-virus interaction", "Hydrogen ion transport", "Hypusine biosynthesis", "Immunity", "Inflammatory response", "Inhibition of host STAT1 by virus", "Inhibition of host STAT2 by virus", "Inhibition of host innate immune response by virus", "Inhibition of host interferon signaling pathway by virus", "Innate immunity", "Inositol biosynthesis", "Ion transport", "Isoprene biosynthesis", "Keratinization", "Leukotriene biosynthesis", "Lipid biosynthesis", "Lipid degradation", "Lipid metabolism", "Lipid transport", "Meiosis", "Melanin biosynthesis", "Methionine biosynthesis", "Methotrexate resistance", "Mitosis", "Molybdenum cofactor biosynthesis", "Myogenesis", "Necrosis", "Neurogenesis", "Neurotransmitter degradation", "Neurotransmitter transport", "Nonsense-mediated mRNA decay", "Notch signaling pathway", "Nucleotide biosynthesis", "Nucleotide metabolism", "One-carbon metabolism", "Oogenesis", "Osteogenesis", "Pentose shunt", "Peptide transport", "Peroxisome biogenesis", "Phagocytosis", "Phenylalanine catabolism", "Phospholipid biosynthesis", "Phospholipid metabolism", "Plasminogen activation", "Polyamine biosynthesis", "Porphyrin biosynthesis", "Potassium transport", "Proline biosynthesis", "Proline metabolism", "Prostaglandin biosynthesis", "Prostaglandin metabolism", "Protein biosynthesis", "Protein transport", "Purine biosynthesis", "Purine salvage", "Pyridine nucleotide biosynthesis", "Pyrimidine biosynthesis", "RNA-mediated gene silencing", "Respiratory chain", "Ribosome biogenesis", "Sensory transduction", "Serine biosynthesis", "Sexual differentiation", "Sodium transport", "Sodium/potassium transport", "Spermatogenesis", "Spermidine biosynthesis", "Sphingolipid metabolism", "Steroid biosynthesis", "Steroid metabolism", "Sterol biosynthesis", "Sterol metabolism", "Stress response", "Sugar transport", "Symport", "Tetrahydrobiopterin biosynthesis", "Transcription", "Transcription regulation", "Transcription termination", "Translation regulation", "Translocation", "Transport", "Tricarboxylic acid cycle", "Tyrosine catabolism", "Ubiquinone biosynthesis", "Ubl conjugation pathway", "Unfolded protein response", "Urea cycle", "Viral RNA replication", "Viral immunoevasion", "Viral penetration into host nucleus", "Virus entry into host cell", "Vision", "Wnt signaling pathway", "Xylose metabolism", "Zinc transport", "mRNA capping", "mRNA processing", "mRNA splicing", "mRNA transport", "rRNA processing", "tRNA processing"], "available_proteins": ["AAAS", "AAR2", "AARS", "AARS2", "ABCB1", "ABCB10", "ABCB6", "ABCB7", "ABCB8", "ABCC4", "ABCD3", "ABCE1", "ABCF3", "ABHD12", "ABHD6", "ABRAXAS2", "ACAA1", "ACAA2", "ACACA", "ACACB", "ACAD11", "ACADM", "ACADSB", "ACADVL", "ACAT1", "ACBD3", "ACBD5", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT7", "ACOT8", "ACOX1", "ACOX3", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACSL6", "ACTL6A", "ACTN4", "ACTR3", "ACTR8", "ADA", "ADAR", "ADI1", "ADK", "ADNP", "ADPGK", "ADSL", "ADSS", "AFDN", "AGL", "AGPAT1", "AGPAT5", "AGPS", "AHCTF1", "AHCY", "AHCYL1", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AKAP8", "AKAP8L", "AKT2", "ALDH18A1", "ALDH3A2", "ALDH4A1", "ALDOA", "ALDOC", "ALKBH5", "ANAPC1", "ANAPC16", "ANAPC2", "ANAPC4", "ANAPC5", "ANAPC7", "ANKFY1", "ANKLE2", "ANKRD17", "ANLN", "ANO6", "ANP32A", "ANP32B", "ANXA1", "ANXA11", "ANXA2", "AP1B1", "AP1G1", "AP1M1", "AP1S1", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "APEX1", "API5", "APOO", "APP", "APPL1", "APRT", "AQR", "ARCN1", "ARF4", "ARF6", "ARFGAP1", "ARFIP2", "ARG2", "ARGLU1", "ARHGEF2", "ARID1A", "ARID2", "ARID3B", "ARIH2", "ARL2", "ARL3", "ARL6IP1", "ARL8A", "ARMC10", "ARMT1", "ARVCF", "ASAH1", "ASB6", "ASCC2", "ASCC3", "ASH2L", "ASNA1", "ASNS", "ATAD2", "ATAD5", "ATG3", "ATG9A", "ATIC", "ATP13A1", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP2B4", "ATP2C1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1D", "ATP6V1E1", "ATP6V1H", "ATP7A", "ATP7B", "ATRIP", "AUP1", "AURKA", "BABAM1", "BABAM2", "BAG3", "BAG6", "BANF1", "BARD1", "BAZ1A", "BAZ1B", "BAZ2A", "BCAP31", "BCAS2", "BCAS3", "BCCIP", "BCL2L12", "BCLAF1", "BICD2", "BIRC6", "BLM", "BMS1", "BNIP1", "BOP1", "BPTF", "BRAP", "BRCA1", "BRD1", "BRD2", "BRD4", "BRIX1", "BRMS1L", "BSG", "BTF3", "BUB1B", "BUB3", "BUD23", "BUD31", "BYSL", "BZW1", "BZW2", "C1QBP", "C2CD5", "CACYBP", "CAD", "CAMK2G", "CAMSAP3", "CAND1", "CAND2", "CANX", "CAPRIN1", "CARS", "CBX2", "CBX3", "CBX5", "CBX8", "CC2D1A", "CCAR1", "CCAR2", "CCDC22", "CCDC59", "CCDC86", "CCDC93", "CCNB1", "CD2AP", "CD2BP2", "CD3EAP", "CD47", "CDC123", "CDC16", "CDC23", "CDC27", "CDC42", "CDC5L", "CDC73", "CDCA2", "CDCA5", "CDCA7L", "CDCA8", "CDH2", "CDIPT", "CDK1", "CDK12", "CDK2", "CDK4", "CDK5", "CDK5RAP1", "CDK5RAP3", "CDK6", "CDK9", "CDKAL1", "CDS2", "CEBPZ", "CELF1", "CELF2", "CENPV", "CEP55", "CERS2", "CERS5", "CETN2", "CFL1", "CHAF1A", "CHAF1B", "CHCHD3", "CHD1", "CHD1L", "CHD4", "CHD8", "CHID1", "CHKA", "CHMP2B", "CHMP3", "CHMP4B", "CHMP5", "CHMP7", "CHORDC1", "CHST14", "CHTF18", "CHTOP", "CIAPIN1", "CIB1", "CIRBP", "CISD2", "CIT", "CKAP2", "CKAP5", "CLASP1", "CLASP2", "CLCC1", "CLCN3", "CLCN7", "CLIC1", "CLINT1", "CLPTM1", "CLPTM1L", "CLSPN", "CLTA", "CLTC", "CMPK1", "CMTR1", "CNNM3", "CNNM4", "CNOT1", "CNOT4", "CNOT9", "COG2", "COG3", "COG5", "COG6", "COG7", "COL4A3BP", "COMMD8", "COMT", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS6", "COPZ1", "COQ8A", "COQ9", "CORO7", "COX2", "CPNE1", "CPOX", "CPSF1", "CPSF2", "CPSF3", "CPSF6", "CPSF7", "CPT1A", "CPT2", "CRNKL1", "CS", "CSE1L", "CSK", "CSNK1A1", "CSNK2A1", "CSNK2A2", "CSNK2B", "CSRP2", "CSTF1", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTPS2", "CTR9", "CTTN", "CTU2", "CUL1", "CUL2", "CUL3", "CUL4A", "CUL4B", "CUL5", "CWC15", "CWC22", "CXADR", "CYB5B", "CYB5R1", "CYB5R3", "CYC1", "CYFIP1", "CYFIP2", "CYP51A1", "DAGLB", "DAP3", "DARS", "DARS2", "DAZAP1", "DBN1", "DBNL", "DCAF1", "DCAF13", "DCAF7", "DCAF8", "DCP1B", "DCPS", "DCTD", "DCTN1", "DCTN3", "DCUN1D1", "DCXR", "DDB1", "DDRGK1", "DDT", "DDX1", "DDX17", "DDX20", "DDX21", "DDX23", "DDX28", "DDX39A", "DDX39B", "DDX3X", "DDX41", "DDX46", "DDX47", "DDX5", "DDX51", "DDX54", "DDX56", "DENR", "DERL1", "DERL2", "DFFA", "DHCR24", "DHCR7", "DHFR", "DHPS", "DHTKD1", "DHX15", "DHX16", "DHX29", "DHX30", "DHX36", "DHX38", "DHX8", "DHX9", "DIAPH1", "DIAPH2", "DICER1", "DIDO1", "DIMT1", "DIS3", "DKC1", "DLAT", "DLG1", "DLGAP5", "DLST", "DMAP1", "DNA2", "DNAAF5", "DNAJA3", "DNAJB1", "DNAJC13", "DNAJC2", "DNAJC3", "DNM1L", "DNM2", "DNMT1", "DNPH1", "DNTTIP2", "DOCK7", "DOHH", "DPF2", "DPY30", "DPYSL2", "DSC3", "DSG2", "DST", "DTX3L", "DTYMK", "DUS2", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNC2H1", "DYNLL1", "DYNLL2", "EARS2", "EBNA1BP2", "EBP", "ECH1", "ECHS1", "ECI1", "ECSIT", "EDF1", "EDRF1", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EFL1", "EFTUD2", "EHBP1", "EHD1", "EI24", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2D", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E", "EIF4E2", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAC2", "ELL", "ELMO2", "ELMOD2", "ELOA", "ELOB", "ELP1", "ELP2", "ELP3", "ELP4", "EMG1", "EML4", "ENO1", "ENO2", "ENY2", "EPB41", "EPB41L2", "EPB41L3", "EPHA7", "EPHX1", "EPHX2", "EPN1", "EPRS", "EPS15L1", "ERAL1", "ERAP1", "ERAP2", "ERC1", "ERCC2", "ERCC3", "ERCC6L", "ERG28", "ERGIC1", "ERGIC3", "ERH", "ERLIN1", "ERLIN2", "ERO1A", "ERO1B", "ESF1", "ESYT1", "ESYT2", "ETF1", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXD2", "EXO1", "EXOC2", "EXOC3", "EXOC5", "EXOC6", "EXOC7", "EXOC8", "EXOSC1", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC8", "EXOSC9", "EYA4", "EZR", "F11R", "FADS2", "FAF1", "FAF2", "FAH", "FAM162A", "FAM208A", "FAM50A", "FANCD2", "FANCI", "FAR1", "FARSA", "FARSB", "FASN", "FASTKD5", "FBL", "FDFT1", "FDPS", "FDXR", "FECH", "FEN1", "FERMT2", "FGFR1OP", "FH", "FHL1", "FIP1L1", "FIS1", "FKBP8", "FLII", "FLNA", "FLNB", "FLOT2", "FMR1", "FOXC1", "FOXK1", "FOXRED1", "FRYL", "FSD1", "FTSJ3", "FUBP1", "FUBP3", "FXR1", "G3BP1", "G3BP2", "G6PD", "GABARAPL2", "GADD45GIP1", "GAK", "GALK1", "GALM", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GATAD2B", "GATB", "GBA", "GBF1", "GCFC2", "GCLC", "GCN1", "GEMIN4", "GEMIN5", "GEMIN8", "GET4", "GFM1", "GFPT1", "GGA1", "GGT7", "GHITM", "GINS2", "GINS3", "GINS4", "GLE1", "GLTP", "GM2A", "GMPS", "GNAI1", "GNAI2", "GNAI3", "GNL2", "GNL3L", "GNPDA1", "GOLGA2", "GOLIM4", "GOLT1B", "GORASP2", "GOSR1", "GOT1", "GOT2", "GPAA1", "GPAM", "GPAT4", "GPHN", "GPI", "GPKOW", "GPR89B", "GRB2", "GRSF1", "GRWD1", "GSK3B", "GSPT1", "GSS", "GSTZ1", "GTF2E1", "GTF2E2", "GTF2F1", "GTF2H1", "GTF2H4", "GTF2I", "GTF3C1", "GTF3C2", "GTF3C3", "GTF3C4", "GTF3C5", "GTPBP10", "GTPBP3", "GTPBP4", "GUF1", "GYG1", "GYS1", "HACD3", "HACL1", "HADH", "HADHA", "HADHB", "HARS2", "HAUS1", "HAUS3", "HAUS4", "HAUS5", "HAUS6", "HBS1L", "HCFC1", "HDAC1", "HDAC2", "HDGF", "HDLBP", "HEATR1", "HECTD1", "HECTD3", "HELLS", "HGS", "HIBADH", "HIBCH", "HINT2", "HIRA", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLTF", "HMBS", "HMCES", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMGCR", "HMGCS1", "HMOX1", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH3", "HNRNPK", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HOOK2", "HOOK3", "HPRT1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSD17B7", "HSP90AA1", "HSP90AB1", "HSPA1B", "HSPA2", "HSPA4", "HSPA4L", "HSPA8", "HSPD1", "HSPE1", "HSPH1", "HTATSF1", "HTT", "HUWE1", "HYOU1", "IARS", "IARS2", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDH3G", "IDI1", "IFIT5", "IFT27", "IFT81", "IGBP1", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IK", "IKBKB", "ILF2", "ILF3", "ILVBL", "IMP3", "IMP4", "IMPDH1", "IMPDH2", "INA", "INPPL1", "INTS3", "INTS7", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQCB1", "IQGAP1", "ISG20L2", "IST1", "ISY1", "ISYNA1", "ITCH", "ITGB1", "ITPA", "ITSN2", "IVD", "IWS1", "JAGN1", "JMJD6", "JUP", "KARS", "KAT7", "KDELR1", "KDM1A", "KDM1B", "KDM2A", "KDM3B", "KDM5A", "KDSR", "KHDRBS1", "KHDRBS3", "KHSRP", "KIAA0319L", "KIAA0391", "KIAA1468", "KIDINS220", "KIF11", "KIF18A", "KIF18B", "KIF20A", "KIF23", "KIF2A", "KIF2C", "KIF3A", "KIFBP", "KIN", "KLC1", "KLHL11", "KMT2A", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNA6", "KPNB1", "KRR1", "LACTB", "LAMB1", "LAMC1", "LAMP1", "LAMP2", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LAS1L", "LASP1", "LBR", "LCLAT1", "LDAH", "LDLR", "LETM1", "LGALS3", "LGALS3BP", "LIG1", "LIG3", "LIMA1", "LIN9", "LIPA", "LLGL1", "LMAN2", "LPCAT1", "LPGAT1", "LRP1", "LRPPRC", "LRRC8C", "LRSAM1", "LRWD1", "LSM14B", "LSM2", "LSM4", "LSM6", "LSM7", "LSS", "LTA4H", "LTN1", "LUC7L3", "LYAR", "LYN", "LYPLA1", "M6PR", "MACF1", "MAEA", "MAGT1", "MALT1", "MANF", "MAP1S", "MAPK1", "MAPK14", "MAPRE1", "MAPRE2", "MARCH5", "MARS", "MARS2", "MAT2A", "MAT2B", "MATR3", "MAU2", "MAVS", "MBD3", "MBOAT7", "MCAM", "MCL1", "MCM10", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCMBP", "MCU", "MCUB", "MCUR1", "MDC1", "MDH1", "MDH2", "MECP2", "MED14", "MED17", "MED22", "MED23", "MED24", "MED4", "MESD", "METTL3", "MFN2", "MFSD10", "MFSD3", "MFSD5", "MGEA5", "MGST2", "MIA3", "MICU1", "MIF", "MINDY3", "MKI67", "MKRN2", "MLEC", "MMS19", "MOCOS", "MON2", "MORC2", "MORF4L1", "MORF4L2", "MOSPD2", "MOV10", "MPC2", "MPG", "MPHOSPH10", "MPHOSPH6", "MPHOSPH8", "MRC2", "MRE11", "MRPL41", "MRPL58", "MRPS27", "MRRF", "MRTO4", "MSH2", "MSH3", "MSH6", "MSMO1", "MSN", "MTA1", "MTAP", "MTBP", "MTCH1", "MTCH2", "MTHFD1L", "MTHFD2", "MTMR2", "MTMR6", "MTO1", "MTOR", "MTPAP", "MTR", "MTX1", "MTX2", "MTX3", "MUL1", "MVD", "MYBBP1A", "MYCBP", "MYCBP2", "MYDGF", "MYH10", "MYH14", "MYH9", "MYO1C", "MYO1D", "MYO6", "NAA15", "NAE1", "NAF1", "NAMPT", "NAP1L1", "NAPA", "NAPG", "NARS", "NASP", "NAT10", "NAXE", "NBAS", "NBN", "NCAPD2", "NCAPD3", "NCAPG", "NCAPG2", "NCAPH", "NCBP1", "NCBP3", "NCEH1", "NCKAP1", "NCOA5", "NCOR1", "NCSTN", "ND1", "NDC1", "NDC80", "NDUFA10", "NDUFA11", "NDUFA13", "NDUFA4", "NDUFA5", "NDUFA7", "NDUFA8", "NDUFA9", "NDUFAF4", "NDUFB10", "NDUFB3", "NDUFB4", "NDUFB5", "NDUFB6", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS6", "NDUFS7", "NDUFS8", "NDUFV1", "NDUFV2", "NECAP2", "NEDD1", "NEDD4L", "NEK9", "NELFA", "NELFCD", "NELFE", "NES", "NFS1", "NHP2", "NIP7", "NIPBL", "NISCH", "NKRF", "NLE1", "NLRX1", "NME1", "NME2", "NOA1", "NOC2L", "NOL11", "NOL8", "NOL9", "NONO", "NOP14", "NOP2", "NOP53", "NOP56", "NOP58", "NOSIP", "NOTCH2", "NPC1", "NPC2", "NPLOC4", "NPM1", "NRDE2", "NRP1", "NSA2", "NSD1", "NSD2", "NSD3", "NSDHL", "NSF", "NSMCE2", "NSUN2", "NT5C2", "NT5C3A", "NT5C3B", "NTHL1", "NUBP2", "NUCKS1", "NUDC", "NUDCD1", "NUDT21", "NUF2", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP160", "NUP188", "NUP205", "NUP210", "NUP214", "NUP35", "NUP37", "NUP43", "NUP50", "NUP54", "NUP58", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NUPL2", "NUSAP1", "NUTF2", "NVL", "NXF1", "NXN", "OCRL", "OGDH", "OGT", "OPA1", "OPA3", "ORC2", "ORC3", "ORC5", "OSBP", "OSBPL11", "OSBPL1A", "OSBPL6", "OSBPL8", "OSBPL9", "OSGEP", "OTUB1", "PA2G4", "PABPC1", "PABPN1", "PACSIN2", "PAF1", "PAFAH1B1", "PAFAH1B2", "PAFAH1B3", "PAICS", "PAK1IP1", "PAK2", "PANK4", "PAPOLA", "PARD3", "PARG", "PARK7", "PARN", "PARP1", "PARP2", "PBRM1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCM1", "PCNA", "PDCD11", "PDCD5", "PDCD6", "PDCD6IP", "PDCL3", "PDE12", "PDHA1", "PDHB", "PDK1", "PDK3", "PDS5A", "PDS5B", "PDSS2", "PDZD8", "PECR", "PELO", "PELP1", "PEPD", "PES1", "PEX11B", "PEX14", "PEX19", "PEX3", "PFAS", "PFKL", "PFKM", "PFKP", "PGAM1", "PGAM5", "PGD", "PGK1", "PGM1", "PGM2", "PGM3", "PGP", "PHB", "PHB2", "PHF10", "PHF2", "PHF5A", "PHF6", "PHGDH", "PHKA1", "PHKB", "PI4KB", "PICALM", "PIGG", "PIGK", "PIGS", "PIGT", "PIGU", "PIH1D1", "PIK3C2A", "PIK3R2", "PIN1", "PIR", "PISD", "PITHD1", "PITPNA", "PITPNB", "PKM", "PKMYT1", "PKN1", "PKN2", "PLA2G15", "PLAA", "PLBD2", "PLCG1", "PLD3", "PLD6", "PLIN3", "PLK1", "PLRG1", "PMVK", "PNKP", "PNN", "PNP", "PNPLA6", "PNPLA8", "PNPT1", "POFUT1", "POGZ", "POLA1", "POLA2", "POLD1", "POLD2", "POLDIP2", "POLDIP3", "POLE", "POLE2", "POLG", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2B", "POLR2C", "POLR2D", "POLR2E", "POLR2G", "POLR2L", "POLR3A", "POLR3B", "POLR3C", "POLRMT", "POP1", "POP4", "PPAT", "PPCDC", "PPHLN1", "PPID", "PPIE", "PPIF", "PPIH", "PPOX", "PPP1CA", "PPP1CB", "PPP1R8", "PPP2R1A", "PPP5C", "PPP6C", "PPT1", "PPWD1", "PQBP1", "PRAF2", "PRC1", "PRCC", "PRDX6", "PREB", "PRIM1", "PRIM2", "PRKAA1", "PRKAA2", "PRKAG1", "PRKCB", "PRKDC", "PRMT5", "PRPF19", "PRPF3", "PRPF31", "PRPF38B", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPS2", "PRPSAP1", "PRPSAP2", "PSAP", "PSAT1", "PSIP1", "PSMA1", "PSMA3", "PSMA4", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC3", "PSMD10", "PSMD14", "PSME3", "PSME4", "PSPC1", "PTBP1", "PTBP2", "PTCD1", "PTCD3", "PTDSS1", "PTDSS2", "PTGES2", "PTGES3", "PTGR1", "PTK2", "PTK7", "PTPN23", "PTPRF", "PTRH2", "PUF60", "PURA", "PUS1", "PUS7", "PWP1", "PXN", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QDPR", "QKI", "QRSL1", "QTRT2", "RAB10", "RAB12", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB1B", "RAB23", "RAB24", "RAB2A", "RAB35", "RAB3B", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RAB8A", "RAB9A", "RABGAP1", "RACGAP1", "RACK1", "RAD18", "RAD21", "RAD23A", "RAD23B", "RAD50", "RAE1", "RAI14", "RALA", "RALY", "RAN", "RANBP2", "RANBP3", "RANBP6", "RAPGEF2", "RARS", "RARS2", "RBBP4", "RBBP5", "RBBP6", "RBBP7", "RBM10", "RBM14", "RBM17", "RBM22", "RBM25", "RBM28", "RBM3", "RBM39", "RBM4", "RBM45", "RBM5", "RBM8A", "RBMX", "RBMXL1", "RBPJ", "RCC1", "RCC2", "RCL1", "REEP4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RFT1", "RIF1", "RINT1", "RIPK1", "RMDN3", "RNASET2", "RNF2", "RNF20", "RNF40", "RNMT", "RNPS1", "ROBO1", "ROCK1", "ROCK2", "RP2", "RPA1", "RPA2", "RPAP1", "RPF1", "RPF2", "RPL10", "RPL13A", "RPP30", "RPP38", "RPRD1B", "RPS3", "RPS3A", "RPS6KA1", "RPS6KA3", "RPSA", "RPTOR", "RPUSD3", "RRBP1", "RREB1", "RRM1", "RRM2", "RRP1", "RRP1B", "RRP36", "RRP8", "RRP9", "RRS1", "RSF1", "RSL24D1", "RTCB", "RTN3", "RTN4", "RTN4IP1", "RTRAF", "RUFY1", "RUVBL1", "RUVBL2", "S100A13", "SAE1", "SAFB", "SAFB2", "SALL2", "SAMD4B", "SAMHD1", 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0000000000000000000000000000000000000000..7d6b432405012b0ebdd934a5bfd950d17a0abe51 --- /dev/null +++ b/protein_atlas_disease_involvement/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:cd667590947f23902428d18e4bd2b205f6827e11b72aac21a99c3f2333fbe1d9 +size 79978 diff --git a/protein_atlas_disease_involvement/df_merge.tsv b/protein_atlas_disease_involvement/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..5f790383cf2fd2c2cbd7c012f9aac3c303a33c82 --- /dev/null +++ b/protein_atlas_disease_involvement/df_merge.tsv @@ -0,0 +1,5 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Primary mitochondrial disease 30 91 3.145573631213818 0.0016576146384175 27.53640776699029 92.44660194174756 0.9978626953080288 0.3665723479658412 11.863754653333944 10.66022291187525 1.7959996823414457 0.3879563837717744 7.032997673420174e-08 0.0082948362693521 3.090226013595508e-05 1.194345839656391e-05 2.9804095218049224e-08 +Ichthyosis 2 9 2.421733374136775 0.0154466792051894 2.424757281553398 8.70873786407767 0.6701903086786922 0.3798909770564678 1.5631275250389387 1.4270688811262522 1.102920967881483 0.3152318826682235 0.0881871975325996 1.0 0.0255840399150975 0.0239571113561098 0.1298078118605267 +Cataract 8 26 2.3723959136195547 0.0176731418662869 7.509708737864078 26.679611650485437 0.6066406061606927 0.4718259290301406 3.570701015264242 3.2395121058789256 1.0572468917106954 0.3422408621391183 0.0004612005893323 0.2406936845278361 0.1039407380726692 6.09484178195159e-05 0.0015622461376846 +Gangliosidosis 3 5 2.2352967265663533 0.0253978748346763 2.8567961165048543 4.902912621359223 0.2158556094961241 0.1574800557957235 1.2213224676890235 0.2960767122713962 1.9039254823866087 0.2239345049259472 1.3349717803917027e-05 0.0002241871259369 0.0008973897437505 0.0055254488719224 2.639864710894744e-05 diff --git a/protein_atlas_disease_involvement/metrics.json b/protein_atlas_disease_involvement/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..9db1f3db098e565821eca7fe04d9f8abd808fe09 --- /dev/null +++ b/protein_atlas_disease_involvement/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3221, + "annotations_size": 118, + "title": "Average number of proteins per term", + "value": 21.35593220338983 +} \ No newline at end of file diff --git a/protein_atlas_disease_involvement/paths.json b/protein_atlas_disease_involvement/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..7cf58ea562afe7c1739e5ba12f84dd0ccc35f564 --- /dev/null +++ b/protein_atlas_disease_involvement/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/protein_atlas_disease_involvement/fragment/C201/C201_val_log2fc"} \ No newline at end of file diff --git a/protein_atlas_disease_involvement/result.tsv b/protein_atlas_disease_involvement/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..16ffda5ef082dd431faddbc5d5d75e375b2eb494 --- /dev/null +++ b/protein_atlas_disease_involvement/result.tsv @@ -0,0 +1,47 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Primary mitochondrial disease 0.5452340708397383 3.145573631213818 0.0016576146384175 0.1777911330816529 0.1955985273332669 91 O14949,Q9P0J0,O60313,P20674,P51530,Q7KZN9,Q99797,Q9Y2R0,O43819,P03886,P22695,O43676,P08574,Q96CU9,P00403,P39210,Q86Y39,O95831,Q70HW3,P13073,Q9BQT8,Q96IX5,O95299,Q9Y6M9,O75208,Q5XKP0,Q9UBX3,O75880,Q53H12,P12235 30 +Ichthyosis 0.7688087429382336 2.421733374136775 0.0154466792051894 0.8406946067443064 0.2088975423280095 9 P04062,P51648 2 +Cataract 0.582266795528738 2.3723959136195547 0.0176731418662869 0.8780420343167272 0.2088975423280095 26 Q9UG56,O00400,Q53H12,Q15800,P08670,Q15125,Q9H6K4,O76024 8 +Gangliosidosis 0.8672518720491195 2.2352967265663533 0.0253978748346763 0.9519572590013288 0.2148091286057948 5 P16278,P07602,P17900 3 +Congenital disorder of glycosylation 0.544577517577971 1.892459624994032 0.0584297682226229 0.9991784747540304 0.3265906368598983 20 Q8N511,Q9BT22,Q15904,Q96AA3,O75787,P51571,P46977 7 +Charcot-Marie-Tooth disease 0.4978377757397872 1.730656167223444 0.0835131074717676 0.9999660454125332 0.4001941220407292 24 P02545,O95831,Q6UWE0,P07196,Q8TB36,P54802,P39210,P05023 8 +Diabetes mellitus 0.5948395559578668 1.7236960284898692 0.0847627323650339 0.9999710947909408 0.4001941220407292 12 P03886,O76024 2 +Mucopolysaccharidosis 0.74950904139894 1.7235622946635796 0.0847868902628663 0.9999711846813027 0.4001941220407292 5 P16278,P34059,P54802 3 +Gaucher disease 0.9751475613544568 1.6613134450384102 0.0966505111190594 0.9999938200526678 0.4386446273865004 2 P07602 1 +Alzheimer disease 0.7271078002217719 1.6233201027642712 0.1045209943582099 0.9999977994148176 0.4567954568247693 5 P03886 1 +Neurodegeneration 0.4379737094422701 1.5407682876136386 0.1233731901820143 0.9999998212935098 0.5115814623990467 133 O60313,O00400,P07196,Q9NQT5,P54802,Q9NW15,O14773,O15269,O75787,Q10713,P06865,P05023,P03886,Q6UWE0,Q96RL7,P50897,Q9Y320,Q03252,P05067,P39210,Q13510,Q12768,Q9NRR5,Q04656,P02545,O95831,Q8TB36,Q96A57,Q8TD16,Q15043,P04062,O75503,O75298,Q99720,Q15041,Q14108,Q9UBB4,O95140,O94905,Q8IV08 40 +Parkinsonism 0.5487868131537704 1.378712399222359 0.1679834450184947 0.9999999996236671 0.6006680761267388 11 P04062,Q96A57,Q15043 3 +Peroxisome biogenesis disorder 0.7594644798413029 1.3423939344218931 0.1794683003834956 0.9999999999270116 0.6124032246763598 4 P40855,O75381 2 +Niemann-Pick disease 0.8956197576887167 1.3357071107926592 0.1816450242684117 0.9999999999466512 0.6124032246763598 2 O15118 1 +Dystonia 0.6293189305964616 1.3138932653605009 0.1888821253887032 0.9999999999812972 0.613441193811384 6 P51572,Q15043 2 +Amyloidosis 0.7501329435782655 1.303658031600117 0.1923502048391627 0.9999999999887196 0.613441193811384 4 P03886 1 +Emery-Dreifuss muscular dystrophy 0.6076219386190895 1.2084908923368285 0.2268584969508613 0.9999999999999348 0.6268412199697271 6 P50402,P02545,Q8WXH0 3 +Neuronal ceroid lipofuscinosis 0.8356121814791588 1.136900028433102 0.2555800802481307 0.9999999999999992 0.6556184667234658 3 P50897,O75503 2 +Hereditary spastic paraplegia 0.4534536382347064 1.0599413041861447 0.2891713031889287 1.0 0.6881210232172585 15 O00400,Q8IY17,O75477,O94905,Q12768,O75298,Q15041 7 +Ehlers-Danlos syndrome 0.6883098265587093 1.047343147437286 0.2949413426488667 1.0 0.6881210232172585 4 Q9NWM8,Q8NCH0 2 +Progressive external ophthalmoplegia 0.687016673167855 1.0420074199887004 0.2974082388481371 1.0 0.6881210232172585 4 P12235 1 +Zellweger syndrome 0.7952144188937065 0.9833658206164904 0.325427425952719 1.0 0.7018733663427695 3 P40855,O75381 2 +Rhizomelic chondrodysplasia punctata 0.8042870456663505 0.9679037425660896 0.3330924450440262 1.0 0.7018733663427695 2 O00116 1 +Parkinson disease 0.4968196102645422 0.8523672267420636 0.394010304169476 1.0 0.7748869315333029 8 P04062 1 +Craniosynostosis 0.6272409523133351 0.7984951523367532 0.4245832051811904 1.0 0.8080777130867817 4 P16435 1 +Leigh syndrome 0.4608105690237106 0.7585974317048488 0.4480934095154585 1.0 0.8082777260326567 9 Q7KZN9 1 +Spinocerebellar ataxia 0.4766179950166072 0.7453834216716331 0.4560399630585829 1.0 0.8082777260326567 8 Q9UBB4,O14773,Q8IV08,Q9UNE7 4 +FDA approved drug targets 0.3512332082049912 0.675146722928016 0.4995825514408509 1.0 0.858162247713573 118 P38435,P05141,P20020,P55011,O75330,P05023,P03886,Q16836,P16615,P98194,P31350,P23634,P05067,P50416,Q13423,Q16850,Q16739,P49354,Q14534,Q99720,P49721,P23786,P12236,Q7L0J3,P10253,P04035,P12235,P14324,P21964 29 +Fanconi anemia 0.6986725854247514 0.6327152115399418 0.5269196344771216 1.0 0.858162247713573 3 P38398 1 +Neuropathy 0.3332074082440349 0.629402929940294 0.5290853003005069 1.0 0.858162247713573 50 P02545,Q9HC21,O95831,Q6UWE0,P07196,Q8TB36,P54802,P39210,O15269,P05023 10 +Disease variant 0.2604901699381521 0.6266373435457245 0.530896983755007 1.0 0.858162247713573 812 O14949,P20674,Q9BXW9,Q9NQT5,Q9H2D1,P51530,Q86XL3,Q9UHX1,Q15800,P03886,O43676,P50897,P07602,P17900,Q13510,P51648,Q13423,O95470,P35670,O15118,O75844,P02545,Q70HW3,P13073,P04062,Q9Y6M9,Q99720,Q14108,Q9H6K4,Q8N5M9,Q8WWV3,Q8N511,O00165,Q9UBX3,Q8NCH0,Q96A33,Q8IV08,P13473,Q5H8A4,P46977,Q06136,O00400,P38435,Q15392,Q9BT22,Q9NX62,Q92542,Q7KZN9,P54802,P10619,P40939,P16615,P22830,O43175,P42892,Q96CU9,Q12768,P51798,O76024,Q01105,Q96J42,Q8TB36,Q9BQT8,Q96A57,Q15043,O75503,P08670,Q15041,Q15125,Q14739,Q9UG56,Q9UJS0,Q53H12,Q9Y619,Q9P0J0,Q9NVI7,Q9H9P8,Q96AA3,Q5HYI8,Q99797,Q9NW15,O15269,O43819,Q10713,P22695,Q9NZ01,Q16836,Q96RL7,P16278,P98194,Q6NUK1,P50402,P06280,P00403,P05067,P39210,Q04656,P16435,P61916,Q6P4Q7,O75298,Q15645,O14681,P23786,P04637,Q15904,Q9NVH6,Q9NP58,P10253,O75880,O00116,P53701,P12235,O75962,O00203,O60313,Q9HC21,P07196,Q96N66,O75787,P09622,P06865,P53007,Q6UWE0,Q92643,P10644,Q9Y320,O14656,Q03252,Q9NRR5,P50416,O15460,P48651,Q9UBM7,O95831,P57678,P35573,Q8TD16,O95299,O00584,P51812,Q8NFH4,P21912,Q13144,Q9Y263,O95140,O75746,O14979,P38398,Q9P0J1,P14324,Q2TAA5 152 +Limb-girdle muscular dystrophy 0.4546372837785876 0.4805018519586668 0.6308705866329054 1.0 0.9258359968600938 6 P02545 1 +Amyotrophic lateral sclerosis 0.3807742149971436 0.4729116293886956 0.6362762276935234 1.0 0.9258359968600938 13 Q99720 1 +Congenital myasthenic syndrome 0.6426344586771451 0.4492078622068591 0.6532817163939386 1.0 0.9258359968600938 3 P53007 1 +Cardiomyopathy 0.3391326653879908 0.4468111760876994 0.6550114011862667 1.0 0.9258359968600938 22 P02545,P50402,Q53H12,O43819,P12235 5 +Leukodystrophy 0.3452273367891825 0.4133971138043994 0.6793156888781948 1.0 0.9320843172979884 19 Q13144,P07602,P20700 3 +Epilepsy 0.2751063685095146 0.3741917720691324 0.7082616450349228 1.0 0.9503722135382976 66 Q92643,O75787,Q13510,O75503,P05023,P03886,Q14108,P16615,Q96RL7 9 +Hermansky-Pudlak syndrome 0.6106374329361957 0.3548262270442713 0.7227197788450008 1.0 0.9503722135382976 3 O00203 1 +Albinism 0.6106374329361957 0.3548262270442713 0.7227197788450008 1.0 0.9503722135382976 3 O00203 1 +Glycogen storage disease 0.3545449616310046 0.2553145853774892 0.798480135657119 1.0 0.9792228690356906 11 P10253,P35573,P13473 3 +Nephronophthisis 0.5750232991612191 0.2255500549818121 0.8215513901231641 1.0 0.9792228690356906 2 Q15051 1 +Microphthalmia 0.3498944460619618 0.1073305555715569 0.9145267447071612 1.0 1.0 7 Q9NP58 1 +Ciliopathy 0.3123741535060862 0.0755722315084664 0.9397594293152882 1.0 1.0 12 Q96J42 1 +Xeroderma pigmentosum 0.4457906182043905 0.0553523268733206 0.9558577752140036 1.0 1.0 2 P18074 1 +Cockayne syndrome 0.4457906182043905 0.0553523268733206 0.9558577752140036 1.0 1.0 2 P18074 1 +Cushing syndrome 0.3957103402210278 0.0073202923313435 0.9941593039322224 1.0 1.0 3 P10644 1 diff --git a/protein_atlas_disease_involvement/selections.json b/protein_atlas_disease_involvement/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..d1967bda0a8d09ed4bff73988ae33634ae26c972 --- /dev/null +++ b/protein_atlas_disease_involvement/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["Aicardi-Goutieres syndrome", "Albinism", "Allergen", "Alport syndrome", "Alzheimer disease", "Amelogenesis imperfecta", "Amyloidosis", "Amyotrophic lateral sclerosis", "Atrial fibrillation", "Autism", "Autism spectrum disorder", "Bardet-Biedl syndrome", "Bartter syndrome", "Brugada syndrome", "Cancer-related genes", "Cardiomyopathy", "Cataract", "Charcot-Marie-Tooth disease", "Ciliopathy", "Cockayne syndrome", "Cone-rod dystrophy", "Congenital adrenal hyperplasia", "Congenital disorder of glycosylation", "Congenital dyserythropoietic anemia", "Congenital hypothyroidism", "Congenital muscular dystrophy", "Congenital myasthenic syndrome", "Craniosynostosis", "Cushing syndrome", "Deafness", "Diabetes insipidus", "Diabetes mellitus", "Diamond-Blackfan anemia", "Disease variant", "Dwarfism", "Dyskeratosis congenita", "Dystonia", "Dystroglycanopathy", "Ectodermal dysplasia", "Ehlers-Danlos syndrome", "Elliptocytosis", "Emery-Dreifuss muscular dystrophy", "Epidermolysis bullosa", "Epilepsy", "FDA approved drug targets", "Fanconi anemia", "Gangliosidosis", "Gaucher disease", "Glaucoma", "Glutaricaciduria", "Glycogen storage disease", "Gout", "Hereditary hemolytic anemia", "Hereditary nonpolyposis colorectal cancer", "Hereditary spastic paraplegia", "Hermansky-Pudlak syndrome", "Hirschsprung disease", "Holoprosencephaly", "Hypogonadotropic hypogonadism", "Hypotrichosis", "Ichthyosis", "Intrahepatic cholestasis", "Joubert syndrome", "Kallmann syndrome", "Kartagener syndrome", "Leber congenital amaurosis", "Leber hereditary optic neuropathy", "Leigh syndrome", "Leukodystrophy", "Li-Fraumeni syndrome", "Limb-girdle muscular dystrophy", "Lissencephaly", "Long QT syndrome", "MELAS syndrome", "Maple syrup urine disease", "Meckel syndrome", "Mental retardation", "Metachromatic leukodystrophy", "Microphthalmia", "Mucopolysaccharidosis", "Myofibrillar myopathy", "Nemaline myopathy", "Nephronophthisis", "Neurodegeneration", "Neuronal ceroid lipofuscinosis", "Neuropathy", "Niemann-Pick disease", "Non-syndromic deafness", "Obesity", "Oncogene", "Osteogenesis imperfecta", "Osteopetrosis", "Palmoplantar keratoderma", "Parkinson disease", "Parkinsonism", "Peroxisome biogenesis disorder", "Peters anomaly", "Phenylketonuria", "Pontocerebellar hypoplasia", "Premature ovarian failure", "Primary ciliary dyskinesia", "Primary hypomagnesemia", "Primary microcephaly", "Primary mitochondrial disease", "Progressive external ophthalmoplegia", "Proto-oncogene", "Pyropoikilocytosis", "Retinitis pigmentosa", "Rhizomelic chondrodysplasia punctata", "SCID", "Schizophrenia", "Senior-Loken syndrome", "Spinocerebellar ataxia", "Systemic lupus erythematosus", "Tumor suppressor", "Williams-Beuren syndrome", "Xeroderma pigmentosum", "Zellweger syndrome"], "available_proteins": ["AAAS", "AARS", "AARS2", "ABCB1", "ABCB6", "ABCB7", "ABHD12", "ACAA1", "ACAD9", "ACADM", "ACADSB", "ACADVL", "ACAT1", "ACBD5", "ACLY", "ACO1", "ACO2", "ACOX1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN4", "ADA", "ADAR", "ADD3", "ADK", "ADNP", "ADSL", "AFDN", "AFG3L2", "AGK", "AGL", "AGPS", "AHCY", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AKAP9", "AKR1B1", "AKT2", "ALDH18A1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDOA", "ALDOC", "ALG1", "ALG11", "ANAPC1", "ANK3", "ANKLE2", "ANLN", "ANO10", "ANXA1", "ANXA11", "ANXA2", "ANXA4", "ANXA7", "AP1B1", "AP1S1", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "APEX1", "APP", "APPL1", "APRT", "ARCN1", "ARG2", "ARHGDIA", "ARHGEF2", "ARID1A", "ARID2", "ARID3B", "ARL2", "ARL3", "ARL6IP1", "ASAH1", "ASNS", "ASPH", "ASPSCR1", "ATAD1", "ATAD3A", "ATIC", "ATP1A1", "ATP2A2", "ATP2B1", "ATP2B4", "ATP2C1", "ATP5A1", "ATP6AP1", "ATP6AP2", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1E1", "ATP7A", "ATP7B", "ATXN10", "AURKA", "B3GALT6", "B4GAT1", "BAG3", "BANF1", "BARD1", "BAZ1B", "BCAP31", "BCAS3", "BCKDK", "BCLAF1", "BCR", "BCS1L", "BICD2", "BIRC6", "BLM", "BLMH", "BMS1", "BPTF", "BRCA1", "BRD4", "BUB1B", "BUD23", "C19orf70", "C1QBP", "CAD", "CALR", "CAMK2G", "CANT1", "CANX", "CAPN1", "CARS", "CASK", "CAST", "CBX2", "CC2D1A", "CCAR1", "CCAR2", "CCDC22", "CCDC47", "CCDC6", "CCNB1", "CCT5", "CDC16", "CDC27", "CDC37", "CDC42", "CDC73", "CDH2", "CDK1", "CDK12", "CDK2", "CDK4", "CDK5", "CDK6", "CDKAL1", "CEP55", "CFL2", "CHAMP1", "CHD1", "CHD4", "CHD8", "CHMP2B", "CHMP4B", "CHST14", "CISD2", "CIT", "CIZ1", "CKB", "CKMT1A*", "CLCC1", "CLCN7", "CLIC1", "CLN5", "CLPB", "CLPP", "CLPX", "CLTC", "CNNM4", "CNOT1", "COA3", "COA7", "COG2", "COG5", "COG6", "COG7", "COL4A3BP", "COLGALT1", "COMT", "COPA", "COPB2", "COQ8A", "COQ9", "COX15", "COX2", "COX4I1", "COX5A", "CPOX", "CPSF1", "CPT1A", "CPT2", "CRK", "CRTAP", "CSDE1", "CSE1L", "CSNK2A1", "CSNK2A2", "CSNK2B", "CSTB", "CTBP1", "CTNNB1", "CTNNBL1", "CTNND1", "CTSA", "CTSC", "CTTN", "CTU2", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CWF19L1", "CXorf56", "CYB5R3", "CYC1", "CYFIP2", "CYP51A1", "DARS", "DARS2", "DBN1", "DBT", "DCAF8", "DCPS", "DCTN1", "DCUN1D1", "DDOST", "DDRGK1", "DDX10", "DDX3X", "DDX41", "DDX5", "DDX6", "DEK", "DHCR24", "DHCR7", "DHFR", "DHPS", "DHTKD1", "DHX16", "DHX30", "DHX37", "DHX38", "DHX9", "DIAPH1", "DIAPH2", "DIAPH3", "DICER1", "DIS3", "DKC1", "DLD", "DLST", "DNA2", "DNAAF5", "DNAJB1", "DNAJC13", "DNAJC2", "DNAJC3", "DNM1L", "DNM2", "DNMT1", "DOCK7", "DPF2", "DPM1", "DSC3", "DSG2", "DSP", "DST", "DYNC1H1", "DYNC1I2", "DYNC2H1", "DYNLL1", "EARS2", "EBP", "ECE1", "ECHS1", "EDC3", "EEF1A2", "EEF2", "EFL1", "EFTUD2", "EI24", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2S2", "EIF3E", "EIF3F", "EIF3H", "EIF4A2", "EIF4A3", "EIF4E", "EIF4G1", "EIF4H", "EIF5A", "ELAC2", "ELL", "ELP1", "ELP2", "ELP3", "EMC1", "EMD", "EMG1", "EML4", "ENO1", "ENO2", "EPB41", "EPB41L3", "EPHA7", "EPHX1", "EPPK1", "EPRS", "ERAL1", "ERC1", "ERCC2", "ERCC3", "ERGIC1", "ERLIN1", "ERLIN2", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXOC8", "EXOSC2", "EXOSC3", "EXOSC8", "EXOSC9", "EYA4", "EZR", "FADS2", "FAF1", "FAH", "FAM120A", "FAM50A", "FANCD2", "FANCI", "FAR1", "FARSB", "FASN", "FDPS", "FDXR", "FECH", "FEN1", "FGFR1OP", "FH", "FHL1", "FIP1L1", "FKBP10", "FKBP14", "FKBP5", "FKBP8", "FLAD1", "FLNA", "FLNB", "FLNC", "FMR1", "FNTA", "FNTB", "FOXC1", "FOXRED1", "FSCN1", "FTO", "FUBP1", "FUCA1", "FUS", "G6PD", "GAA", "GALK1", "GALM", "GALNS", "GALNT2", "GANAB", "GAPDH", "GARS", "GART", "GATAD2B", "GATB", "GBA", "GCDH", "GCLC", "GDAP1", "GDI1", "GEMIN4", "GFM1", "GFPT1", "GGCX", "GIGYF2", "GLA", "GLB1", "GLDC", "GLE1", "GLMN", "GLO1", "GLRX5", "GLS", "GLUD1", "GM2A", "GMPS", "GNA13", "GNAI1", "GNAI3", "GNAQ", "GNE", "GNPAT", "GNS", "GOLGA5", "GOT1", "GOT2", "GPAA1", "GPD1L", "GPHN", "GPI", "GPRASP2", "GPT2", "GRB2", "GSK3B", "GSR", "GSS", "GSTM3", "GSTZ1", "GTF2E2", "GTF2H1", "GTF2I", "GTPBP3", "GUF1", "GYG1", "GYS1", "H4C1*", "HADH", "HADHA", "HADHB", "HARS2", "HAX1", "HCCS", "HCFC1", "HDAC1", "HDAC2", "HELLS", "HEXA", "HEXB", "HIBCH", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HMBS", "HMGA1", "HMGB3", "HMGCL", "HMGCR", "HMMR", "HMOX1", "HNRNPA1", "HNRNPA2B1", "HNRNPDL", "HNRNPH2", "HNRNPK", "HNRNPU", "HOOK3", "HPRT1", "HPS6", "HSD17B10", "HSD17B4", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA2", "HSPA4", "HSPA8", "HSPA9", "HSPD1", "HSPE1", "HSPH1", "HTT", "HUWE1", "HYOU1", "IARS", "IARS2", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IFT27", "IFT81", "IGBP1", "IGF2R", "IKBKB", "ILF3", "ILK", "IMPAD1", "IMPDH1", "IMPDH2", "INF2", "INPPL1", "INTS1", "INTS8", "IPO7", "IQCB1", "IRF2BPL", "IRS4", "ITGB1", "ITPA", "IVD", "JAGN1", "JUP", "KARS", "KDM1A", "KDM3B", "KDM5A", "KDSR", "KIDINS220", "KIF11", "KIF14", "KIF1A", "KIF22", "KIF2A", "KIF2C", "KIF4A", "KIF5B", "KIFBP", "KMT2A", "KTN1", "L2HGDH", "LACTB", "LAMB1", "LAMC1", "LAMP2", "LARP7", "LARS", "LARS2", "LAS1L", "LASP1", "LBR", "LDHA", "LDHB", "LDLR", "LEMD3", "LGALS3", "LGALS3BP", "LGMN", "LIN9", "LIPA", "LMAN2L", "LMNA", "LMNB1", "LMNB2", "LNPK", "LONP1", "LRBA", "LRP1", "LRPPRC", "LRSAM1", "LSS", "LTA4H", "LYN", "LZTFL1", "M6PR", "MACF1", "MAGED2", "MAGT1", "MALT1", "MAN2B1", "MAP1A", "MAP1B", "MAP4", "MAPK1", "MAPK14", "MARS", "MARS2", "MATR3", "MBOAT7", "MCCC1", "MCCC2", "MCL1", "MCM2", "MCM3", "MCM5", "MCM7", "MDC1", "MDH1", "MDH2", "MECP2", "MED17", "MED23", "MESD", "MFN2", "MICU1", "MIF", "MINPP1", "MIPEP", "MKI67", "MMAB", "MOCOS", "MOGS", "MORC2", "MPI", "MPV17", "MRE11", "MRPL12", "MRPL3", "MRPL44", "MRPS16", "MRPS22", "MRPS23", "MRPS28", "MRPS34", "MRPS7", "MSH2", "MSH6", "MSI2", "MSMO1", "MSN", "MSTO1", "MTA1", "MTHFS", "MTMR14", "MTMR2", "MTO1", "MTOR", "MTPAP", "MTR", "MUT", "MVD", "MYH10", "MYH14", "MYH9", "MYO6", "NAA10", "NAA15", "NAGLU", "NAMPT", "NANS", "NAXE", "NBAS", "NBN", "NCAPD2", "NCAPD3", "NCAPG2", "NCAPH", "NCKIPSD", "NCOR1", "NCSTN", "ND1", "NDUFA10", "NDUFA11", "NDUFA13", "NDUFA4", "NDUFA9", "NDUFAF2", "NDUFAF3", "NDUFAF4", "NDUFB3", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS6", "NDUFS7", "NDUFS8", "NDUFV1", "NDUFV2", "NEDD4L", "NEFL", "NEK9", "NF1", "NFU1", "NHLRC2", "NHP2", "NIPBL", "NISCH", "NME1", "NME2", "NNT", "NONO", "NOP56", "NOTCH2", "NPC1", "NPC2", "NPM1", "NRP1", "NSD1", "NSD2", "NSD3", "NSDHL", "NSMCE2", "NSUN2", "NT5C2", "NT5C3A", "NTHL1", "NUBPL", "NUCB2", "NUDT1", "NUMA1", "NUP107", "NUP133", "NUP155", "NUP160", "NUP188", "NUP205", "NUP214", "NUP37", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NXN", "OARD1", "OAT", "OCLN", "OCRL", "OGDH", "OGT", "OPA1", "OPA3", "OSGEP", "P3H1", "P4HA2", "P4HB", "PABPC1", "PABPN1", "PAF1", "PAFAH1B1", "PAFAH1B2", "PARD3", "PARK7", "PARN", "PARP1", "PARP2", "PBRM1", "PC", "PCBD1", "PCBP1", "PCCA", "PCCB", "PCM1", "PCNA", "PDAP1", "PDHA1", "PDHB", "PDK1", "PDK3", "PDP1", "PDSS2", "PEPD", "PEX11B", "PEX14", "PEX19", "PEX3", "PFKM", "PFN1", "PGK1", "PGM1", "PGM3", "PHB", "PHF6", "PHGDH", "PHIP", "PHKA1", "PHKB", "PI4KA", "PICALM", "PIGG", "PIGK", "PIGS", "PIGT", "PIGU", "PIK3C2A", "PIK3R2", "PIN1", "PINX1", "PISD", "PKM", "PLAA", "PLCG1", "PLD3", "PLEC", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLS3", "PMPCA", "PMPCB", "PMVK", "PNKP", "PNN", "PNP", "PNPLA6", "PNPT1", "POGZ", "POLA1", "POLD1", "POLE", "POLE2", "POLG", "POLR1A", "POLR1B", "POLR1C", "POLR3A", "POLR3B", "POP1", "POR", "PPA2", "PPIB", "PPIF", "PPOX", "PPP1CB", "PPP2R1A", "PPP2R5D", "PPP3CA", "PPP5C", "PPP6C", "PPT1", "PQBP1", "PRC1", "PRCC", "PRDX2", "PRDX4", "PRDX5", "PREPL", "PRKAA1", "PRKAA2", "PRKACA", "PRKAG1", "PRKAR1A", "PRKCB", "PRKCSH", "PRKDC", "PRPF3", "PRPF31", "PRPF4", "PRPF6", "PRPF8", "PSAP", "PSAT1", "PSIP1", "PSMB1", "PSMB2", "PSMB4", "PSMB5", "PSMD12", "PSMD4", "PTDSS1", "PTK2", "PTPN11", "PTPN23", "PTRH2", "PUF60", "PURA", "PUS1", "PUS7", "PYCR1", "PYCR2", "PYGL", "QARS", "QDPR", "QKI", "QRSL1", "RAB10", "RAB18", "RAB23", "RAB3GAP2", "RAB7A", "RAB8A", "RABL3", "RAC1", "RAD21", "RAD23A", "RAD23B", "RANBP2", "RANBP3", "RAP1GDS1", "RAPGEF2", "RARS", "RARS2", "RBBP4", "RBM10", "RBM12", "RBM28", "RBM6", "RBMX", "RBPJ", "RDH11", "RDX", "RFC1", "RFC2", "RFT1", "RHEB", "RINT1", "RIPK1", "RNASEH2A", "RNASET2", "ROCK1", "ROCK2", "RP2", "RPA2", "RPL10", "RPL11", "RPL13", "RPL15", "RPL18", "RPL21", "RPL22", "RPL26", "RPL27", "RPL3", "RPL35", "RPL35A", "RPL5", "RPN1", "RPS10", "RPS15", "RPS15A", "RPS17", "RPS19", "RPS2", "RPS23", "RPS24", "RPS26", "RPS28", "RPS29", "RPS3", "RPS6KA1", "RPS6KA3", "RPS7", "RPSA", "RRAS2", "RRM1", "RRM2", "RSPRY1", "RTN2", "RTN4IP1", "SAMHD1", "SAR1B", "SARS", "SART1", "SBDS", "SCARB2", "SCO1", "SCO2", "SCRIB", "SCYL1", "SDHA", "SDHB", "SDHC", "SEC23A", "SEC23B", "SEC31A", "SEC61A1", "SEC63", "SEPT2", "SEPT9", "SERPINB6", "SERPINH1", "SET", "SETD1A", "SETD2", "SETDB1", "SF3B1", "SFPQ", "SFXN4", "SGPL1", "SH3GL1", "SIGMAR1", "SIN3A", "SKIV2L", "SKP2", "SLC12A2", "SLC16A1", "SLC19A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A19", "SLC25A20", "SLC25A21", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A4", "SLC33A1", "SLC39A14", "SLC3A2", "SLC5A6", "SLC9A3R1", "SMARCA4", "SMARCAD1", "SMARCB1", "SMARCC2", "SMARCD1", "SMC1A", "SMC3", "SMCHD1", "SMN1*", "SMPD4", "SMS", "SND1", "SNRNP200", "SNRPE", "SNX3", "SOAT1", "SOD2", "SON", "SORD", "SPART", "SPATA5", "SPECC1L", "SPEN", "SPR", "SPTAN1", "SPTLC1", "SPTLC2", "SQLE", "SRC", "SRP54", "SRP72", "SRSF3", "SSB", "SSR4", "STAG1", "STAG2", "STAT1", "STAT3", "STMN1", "STRAP", "STRN", "STT3A", "STT3B", "STUB1", "STXBP2", "SUCLA2", "SUCLG1", "SUZ12", "SV2A", "SYNE1", "SYNE2", "TAF15", "TAF6", "TALDO1", "TAP1", "TARDBP", "TARS", "TARS2", "TBC1D4", "TBCD", "TBCE", "TBL1XR1", "TBL2", "TCEA1", "TCOF1", "TECR", "TELO2", "TFAM", "TFG", "TFRC", "THOC2", "THOC6", "TIA1", "TIMM50", "TJP2", "TK1", "TKT", "TLK2", "TMCO1", "TMEM199", "TMEM230", "TMEM43", "TMLHE", "TMTC3", "TMX2", "TNPO3", "TOE1", "TOP1", "TOP2A", "TOP2B", "TOR1A", "TOR1AIP1", "TP53", "TP53BP1", "TP53BP2", "TPD52", "TPI1", "TPM3", "TPM4", "TPP1", "TPR", "TPX2", "TRAF2", "TRAPPC11", "TRIM25", "TRIM27", "TRIM33", "TRIO", "TRIP12", "TRIP13", "TRIP4", "TRMT1", "TRMT10C", "TRMU", "TRRAP", "TSFM", "TSG101", "TTC19", "TUBB", "TUBB2A", "TUBB2B", "TUBB3", "TUBB4A", "TUBB6", "TUBGCP2", "TUFM", "TWNK", "TXLNA", "TXNDC15", "TXNRD1", "TYMS", "U2AF1", "UBA1", "UBE2N", "UBE3A", "UBQLN4", "UBR5", "UBTF", "UFC1", "UFM1", "UGCG", "UGDH", "UGP2", "UMPS", "UPF3B", "UQCC2", "UQCRB", "UQCRC2", "UQCRFS1", "UQCRQ", "UROD", "USMG5", "USP9X", "UTP4", "VANGL1", "VANGL2", "VAPB", "VARS1", "VARS2", "VCL", "VCP", "VIM", "VPS13A", "VPS13C", "VPS16", "VPS33A", "VPS33B", "VPS35", "VPS45", "VPS4A", "VPS51", "VPS53", "VRK1", "WARS", "WASHC4", "WASHC5", "WBP2", "WDR1", "WDR11", "WDR26", "WDR36", "WDR4", "WDR5", "WDR73", "WFS1", "WIPI2", "XPNPEP3", "XPO1", "XRCC1", "XRCC5", "XRCC6", "YARS", "YARS2", "YEATS2", "YME1L1", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAZ", "ZC3H14", "ZCCHC8", "ZMPSTE24", "ZMYM2"], "leading_proteins": ["ABCB6", "AGK", "AGL", "AGPS", "AIFM1", "ALDH3A2", "ALG1", "ALG11", "ANKLE2", "ANO10", "AP3B1", "APP", "ARL6IP1", "ASAH1", "ATAD3A", "ATP1A1", "ATP2A2", "ATP2B1", "ATP2B4", "ATP2C1", "ATP6AP1", "ATP6AP2", "ATP7A", "ATP7B", "ATXN10", "BCAP31", "BICD2", "BRCA1", "C19orf70", "CCDC47", "CHST14", "CLCN7", "CLN5", "CNNM4", "COA3", "COMT", "COQ9", "COX15", "COX2", "COX4I1", "COX5A", "CPT1A", "CPT2", "CTSA", "CYC1", "CYP51A1", "DHCR24", "DHCR7", "DLD", "DNA2", "EBP", "ECE1", "EI24", "EIF2B5", "EMD", "ERCC2", "ERLIN1", "ERLIN2", "EXOSC3", "FANCD2", "FDPS", "FECH", "FKBP14", "FNTA", "FOXRED1", "GAA", "GALNS", "GBA", "GDAP1", "GEMIN4", "GGCX", "GLA", "GLB1", "GM2A", "HADH", "HADHA", "HAX1", "HCCS", "HEXA", "HMGCR", "HMMR", "HNRNPDL", "IMPAD1", "IQCB1", "JAGN1", "KDSR", "L2HGDH", "LAMP2", "LBR", "LMNA", "LMNB1", "LMNB2", "LRSAM1", "MBOAT7", "MFN2", "MIPEP", "MPV17", "MSMO1", "NAGLU", "NCSTN", "ND1", "NDUFA10", "NDUFA11", "NDUFA13", "NDUFB3", "NDUFB9", "NEFL", "NNT", "NPC1", "NPC2", "NUP37", "OPA1", "OPA3", "P4HA2", "PDP1", "PEX14", "PEX19", "PHGDH", "PIGG", "PIGK", "PISD", 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https://git-lfs.github.com/spec/v1 +oid sha256:bd5477347ea0831f3093cc1a47739d42abd27aa3c0e94993b4bdc52e76636d59 +size 141542 diff --git a/protein_atlas_molecular_function/consensus.joblib b/protein_atlas_molecular_function/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..f10b1698b508dc5e465512b3c649aaa58f292dde --- /dev/null +++ b/protein_atlas_molecular_function/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:8c2b0114632b40f0bfb7bf2c17a30e59254bcdf51e50bd22e4c749c60575e981 +size 79935 diff --git a/protein_atlas_molecular_function/df_merge.tsv b/protein_atlas_molecular_function/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..8e8b7950bad067c151ae803f09cb913e2a65d3b4 --- /dev/null +++ b/protein_atlas_molecular_function/df_merge.tsv @@ -0,0 +1,6 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Receptor 14 42 3.3454829551600462 0.000821394075863 13.475728155339803 38.71116504854369 1.6655960679271569 0.1791616261110447 5.431559450288914 6.105192092581698 1.9169648296245776 0.2753083483896962 0.0509452091690629 0.1182182962859897 0.0102187791156541 0.0029507196833789 0.1575835672195456 +Host cell receptor for virus entry 4 15 2.491294721529992 0.0127278492482516 4.509708737864078 15.157766990291265 0.7214109752050332 0.2527966464979699 2.499010078306418 1.9009100692398744 1.5211756979359785 0.2791170769282048 0.0273954727824571 1.0 0.0614247268920475 0.0180565405233996 0.051296284939533 +Glycosidase 9 17 2.485994564917385 0.0129189938644864 7.798543689320389 18.135922330097088 0.5112745472223946 0.1951515073440806 2.9064203812520417 1.9684331341643595 1.9501681029822375 0.2619382904734375 0.0076280534495534 1.0 0.3404254693467198 0.2781824052676386 0.0009402069411773 +Metalloprotease 16 26 2.3613821148159926 0.0182069595195857 8.160194174757281 26.429611650485437 1.390302281711237 0.2661274848815638 3.192614043118206 1.543038499308978 1.1108461579919544 0.309446154241223 0.0090440857287332 1.0 0.4297892617739207 0.1641182363781922 0.0065824357934952 +Translocase 15 28 2.0729775280221028 0.0381743709715916 8.031553398058252 23.23543689320388 0.8266305625937611 0.3429767730570308 3.903132239147793 3.2553774114037415 1.2917497354360188 0.3272657999875639 2.6299462899943383e-05 0.2516504230112798 0.0198486300115185 0.0145897333531984 4.5074720456821366e-06 diff --git a/protein_atlas_molecular_function/metrics.json b/protein_atlas_molecular_function/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..7289b645cc8f4746840923a59e8612bfd96ed6d4 --- /dev/null +++ b/protein_atlas_molecular_function/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3221, + "annotations_size": 94, + "title": "Average number of proteins per term", + "value": 40.07446808510638 +} \ No newline at end of file diff --git a/protein_atlas_molecular_function/paths.json b/protein_atlas_molecular_function/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..d79c3d55e357c49aaede80929ea6614e2b3ab468 --- /dev/null +++ b/protein_atlas_molecular_function/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/protein_atlas_molecular_function/fragment/C201/C201_val_log2fc"} \ No newline at end of file diff --git a/protein_atlas_molecular_function/result.tsv b/protein_atlas_molecular_function/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..6a4e09a777105c82defedfb1085f4b74bc0b3626 --- /dev/null +++ b/protein_atlas_molecular_function/result.tsv @@ -0,0 +1,21 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Receptor 0.667280953992473 3.3454829551600462 0.000821394075863 0.0743348981803513 0.0386055215655616 42 P11279,Q14108,Q9Y5M8,Q99623,P24390,P30825,Q9NS69,Q5KU26,O00264,Q99720,O15173,Q14739,O15118,Q8WTV0 14 +Host cell receptor for virus entry 0.6784518697324635 2.4912947215299917 0.0127278492482516 0.7000372477229887 0.1026901486455982 15 Q14108,P11279,O15118,Q8WTV0 4 +Glycosidase 0.660464658794299 2.485994564917385 0.0129189938644864 0.7054474824952928 0.1026901486455982 17 Q16706,P16278,P35573,P06280,P54802,P10253,P04062,P06865,Q9BTY2 9 +Metalloprotease 0.580728713632827 2.3613821148159926 0.0182069595195857 0.8222231409469887 0.1222467282029327 26 O75844,Q6P179,Q5JRX3,P52888,Q9UIQ6,Q9NZ08,P42892,Q9Y4W6,P55786,P09960,O43847,Q99797,Q7Z2K6,Q96TA2,P14735,Q92905 16 +Translocase 0.5381088594349301 2.0729775280221028 0.0381743709715916 0.9742334395390156 0.1888626774384005 28 Q04656,P06576,Q03519,P98194,P08574,Q03518,Q9HD20,P00403,Q9NP58,P20020,P05023,P03886,Q13423,P35670,P16615 15 +Glycosyltransferase 0.4944115580007846 1.8473461019370496 0.0646969953362039 0.9981399741716384 0.2764326164365079 36 Q8N4A0,Q16739,P43490,Q9BT22,P35573,Q96L58,Q16880,P04062,Q10472,Q13126,P46977,Q2TAA5 12 +Porin 0.8765064247950722 1.8230980103737748 0.0682885478955461 0.998704448259376 0.2790923261817974 4 P21796,P45880 2 +Carboxypeptidase 0.7062701113464149 1.6828309217082102 0.0924078271914305 0.99988991459846 0.347453430239779 6 Q9HB40,P10619 2 +Prenyltransferase 0.8713019621768283 1.2739579073608007 0.202678334198602 0.9999999994330364 0.5150186833706266 3 P49354 1 +Chloride channel 0.7272953446303827 1.2088232392533436 0.2267307614085756 0.9999999999681516 0.5464792710873361 4 Q9C0H2,Q96S66 2 +Muscle protein 0.5717642642526181 1.0338687344601942 0.3011975332141454 0.9999999999999976 0.6154906113506451 6 P46020,P67936 2 +Calcium channel 0.8005591798695234 0.9532501180896504 0.3404633585343031 1.0 0.6531337898413161 2 Q9UM00 1 +Guanine-nucleotide releasing factor 0.4310592567684452 0.9360306604390896 0.3492574017759664 1.0 0.6541154091276211 16 P80303 1 +Protease 0.3240657173811978 0.8098132132183177 0.4180475372869798 1.0 0.7152733655656679 79 Q4J6C6,Q6P179,Q96RU2,P55786,Q99797,O14773,Q7Z2K6,P10619,Q96TA2,Q92905,Q15005,Q92643,Q5JRX3,P53634,Q9UIQ6,P42892,P09960,P50579,O43847,O75844,P67812,Q9NZ08,Q9UPU5,P42785,Q8TCT8,Q8TCT9,Q9HB40,P52888,P28072,O00303,Q9H3G5,P53582 32 +Ion channel 0.4651613195247641 0.7828254948286848 0.4337295940132242 1.0 0.7152733655656679 9 P0CG08,Q9C0H2,Q4KMQ2,Q96S66,Q9UM00,Q8TDW0 6 +Aminopeptidase 0.4216254376467654 0.7247485463210572 0.4686063068693142 1.0 0.7313959514270112 13 Q6P179,Q9UIQ6,Q9NZ08,P55786,P53582 5 +Monooxygenase 0.6970881421923818 0.627266941104228 0.5304842697124725 1.0 0.7671618669688064 3 Q6UW02 1 +Acyltransferase 0.345943614792344 0.572396085702112 0.5670536670888768 1.0 0.7786984998108896 37 Q9HCL2,Q9UJ14,Q96N66,Q9NUQ2,O15269,P23786,Q92604,Q8NF37 8 +Transducer 0.3428668641812876 0.1746232734935504 0.8613756599624554 1.0 0.9874306345911074 10 P50148,P63218,P04899 3 +Lyase 0.2907043898001545 0.1345592518279553 0.8929603608477961 1.0 0.999265165710629 43 Q9UG56,P22830,O95470,P38435,Q9P035,O00584,P53701,P40939,Q96EM0,Q99735 10 diff --git a/protein_atlas_molecular_function/selections.json b/protein_atlas_molecular_function/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..a838a740e06560b6d36f24a2fc723106d8f3f68c --- /dev/null +++ b/protein_atlas_molecular_function/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["Actin capping", "Actin-binding", "Activator", "Acyltransferase", "Allosteric enzyme", "Aminoacyl-tRNA synthetase", "Aminopeptidase", "Aminotransferase", "Antibiotic", "Antimicrobial", "Antioxidant", "Aspartyl protease", "Blood group antigen", "Calcium channel", "Calmodulin-binding", "Carboxypeptidase", "Chaperone", "Chloride channel", "Chromatin regulator", "Cyclin", "Cytokine", "DNA-binding", "DNA-directed DNA polymerase", "Decarboxylase", "Developmental protein", "Dioxygenase", "Dipeptidase", "Elongation factor", "Endonuclease", "Excision nuclease", "Exonuclease", "Fungicide", "GTPase activation", "Glycosidase", "Glycosyltransferase", "Growth factor", "Guanine-nucleotide releasing factor", "Helicase", "Heparin-binding", "Hormone", "Host cell receptor for virus entry", "Hydrolase", "IgE-binding protein", "Initiation factor", "Integrin", "Ion channel", "Isomerase", "Kinase", "Ligase", "Lyase", "Metalloenzyme inhibitor", "Metalloprotease", "Methyltransferase", "Monooxygenase", "Motor protein", "Multifunctional enzyme", "Muscle protein", "Myosin", "Nuclease", "Nucleotidyltransferase", "Oxidoreductase", "Peroxidase", "Phospholipase A2 inhibitor", "Porin", "Prenyltransferase", "Protease", "Protease inhibitor", "Protein phosphatase", "Protein phosphatase inhibitor", "Protein synthesis inhibitor", "RNA-binding", "Receptor", "Repressor", "Ribonucleoprotein", "Ribosomal protein", "Rotamase", "Serine esterase", "Serine protease", "Serine protease inhibitor", "Serine/threonine-protein kinase", "Signal transduction inhibitor", "Thiol protease", "Thiol protease inhibitor", "Threonine protease", "Topoisomerase", "Transducer", "Transferase", "Translational shunt", "Translocase", "Tumor antigen", "Tyrosine-protein kinase", "Voltage-gated channel", "rRNA-binding", "tRNA-binding"], "available_proteins": ["AARS", "AARS2", "AASDHPPT", "AASS", "ABCB1", "ABCB6", "ABCC4", "ABCE1", "ABCF1", "ABHD10", "ABHD12", "ABHD14B", "ABHD6", "ACAA1", "ACAA2", "ACACA", "ACACB", "ACAD11", "ACAD9", "ACADM", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT8", "ACOT9", "ACOX1", "ACOX3", "ACP1", "ACP2", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACSL6", "ACTL6A", "ACTN1", "ACTN4", "ACTR2", "ACTR3", "ADA", "ADAR", "ADD1", "ADD3", "ADH5", "ADI1", "ADK", "ADNP", "ADPGK", "ADSL", "ADSS", "AFG3L2", "AGK", "AGL", "AGPAT1", "AGPAT5", "AGPS", "AHCTF1", "AHCY", "AHCYL1", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AK1", "AK2", "AK3", "AK4", "AK6", "AKAP1", "AKAP8", "AKR1A1", "AKR1B1", "AKR7A2", "AKT2", "ALDH18A1", "ALDH1A2", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALG1", "ALG11", "ALG5", "ALKBH5", "ANKHD1", "ANKRD17", "ANLN", "ANO6", "ANP32A", "ANP32B", "ANP32E", "ANXA1", "ANXA2", "APEH", "APEX1", "APP", "APRT", "AQR", "ARFGAP1", "ARG2", "ARHGAP17", "ARHGDIA", "ARHGEF2", "ARID1A", "ARID2", "ARID3B", "ARIH2", "ARMT1", "ARPC1A", "ARPC2", "ARPC3", "ARPC4", "ASAH1", "ASCC3", "ASH2L", "ASNA1", "ASNS", "ASPH", "ATAD1", "ATAD2", "ATG3", "ATIC", "ATL2", "ATP13A1", "ATP1A1", "ATP2A2", "ATP2B1", "ATP2B4", "ATP2C1", "ATP5B", "ATP6AP2", "ATP6V1A", "ATP6V1B2", "ATP6V1E1", "ATP7A", "ATP7B", "AURKA", "B3GALT6", "B4GAT1", "BABAM1", "BABAM2", "BAG2", "BAG3", "BAG4", "BAG5", "BAG6", "BANF1", "BAP18", "BARD1", "BAZ1B", "BAZ2A", "BCKDK", "BCLAF1", "BCR", "BCS1L", "BIRC6", "BLM", "BLMH", "BLVRA", "BPNT1", "BPTF", "BRAP", "BRCA1", "BRD1", "BRD2", "BRD4", "BRMS1L", "BSG", "BTAF1", "BTF3", "BUB1B", "BUD23", "BZW1", "BZW2", "CAD", "CALD1", "CALR", "CAMK2G", "CANT1", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPRIN1", "CAPZA1", "CAPZB", "CARHSP1", "CARS", "CASK", "CAST", "CBR1", "CBX2", "CBX3", "CBX8", "CC2D1A", "CCAR1", "CCAR2", "CCDC47", "CCNB1", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CDC37", "CDC42", "CDC5L", "CDCA7L", "CDIPT", "CDK1", "CDK12", "CDK2", "CDK4", "CDK5", "CDK5RAP1", "CDK6", "CDK9", "CDKAL1", "CDKN2AIP", "CDS2", "CEBPZ", "CELF1", "CELF2", "CENPB", "CEP55", "CERS2", "CERS5", "CFL1", "CFL2", "CHAC2", "CHAF1A", "CHCHD3", "CHD1", "CHD1L", "CHD4", "CHD8", "CHDH", "CHKA", "CHORDC1", "CHRAC1", "CHST14", "CHTF18", "CHTOP", "CIRBP", "CIT", "CKB", "CKMT1A*", "CLCC1", "CLGN", "CLIC1", "CLPB", "CLPP", "CLPTM1", "CLPX", "CLSPN", "CLUH", "CMAS", "CMPK1", "CMTR1", "CNDP2", "CNN2", "CNN3", "CNOT1", "CNOT4", "CNOT9", "CNP", "COLEC12", "COLGALT1", "COMT", "COPA", "COPS5", "COQ8A", "CORO1B", "CORO1C", "CORO7", "COTL1", "COX2", "COX4I1", "CPD", "CPNE1", "CPOX", "CPSF1", "CPSF2", "CPSF3", "CPSF6", "CPSF7", "CPT1A", "CPT2", "CPVL", "CRYZ", "CS", "CSDE1", "CSGALNACT2", "CSK", "CSNK1A1", "CSNK2A1", "CSNK2A2", "CSRP2", "CSTB", "CSTF2", "CTBP1", "CTBP2", "CTNNB1", "CTPS1", "CTPS2", "CTSA", "CTSC", "CUL5", "CXADR", "CXorf57", "CYB5R1", "CYB5R3", "CYC1", "CYFIP1", "CYP20A1", "CYP51A1", "DAGLB", "DAP3", "DARS", "DARS2", "DAZAP1", "DBN1", "DBNL", "DBT", "DCAF1", "DCAF13", "DCAF7", "DCD", "DCP1B", "DCPS", "DCTD", "DCTPP1", "DCXR", "DDB1", "DDI2", "DDT", "DDX1", "DDX10", "DDX17", "DDX18", "DDX20", "DDX21", "DDX23", "DDX24", "DDX28", "DDX39A", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX50", "DDX51", "DDX52", "DDX54", "DDX56", "DDX6", "DEK", "DENND6A", "DENR", "DHCR24", "DHCR7", "DHFR", "DHPS", "DHRS1", "DHRS13", "DHRS7", "DHRS7B", "DHTKD1", "DHX15", "DHX16", "DHX29", "DHX30", "DHX36", "DHX37", "DHX38", "DHX40", "DHX57", "DHX8", "DHX9", "DIAPH1", "DIAPH2", "DICER1", "DIEXF", "DIMT1", "DIS3", "DKC1", "DLAT", "DLD", "DLST", "DMAP1", "DNA2", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC13", "DNAJC2", "DNAJC21", "DNAJC3", "DNAJC7", "DNAJC8", "DNAJC9", "DNM1L", "DNM2", "DNMT1", "DNPH1", "DOCK7", "DOHH", "DOLPP1", "DPF2", "DPH2", "DPH5", "DPM1", "DPP3", "DPP9", "DPY30", "DPYSL2", "DRG1", "DRG2", "DST", "DSTN", "DTX3L", "DTYMK", "DUS2", "DUSP12", "DUSP3", "DUSP9", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNC2H1", "DYNLL1", "DYNLL2", "EARS2", "EBP", "ECE1", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "EDC3", "EDF1", "EDRF1", "EEF1A2", "EEF1B2", "EEF1D", "EEF1G", "EEF2", "EFL1", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2D", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E", "EIF4E2", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAC2", "ELAVL1", "ELMOD2", "ELP3", "EMD", "EMG1", "ENAH", "ENDOD1", "ENO1", "ENO2", "ENY2", "EP400", "EPB41", "EPB41L2", "EPB41L3", "EPHA7", "EPHX1", "EPHX2", "EPRS", "ERAL1", "ERAP1", "ERAP2", "ERCC2", "ERCC3", "ERCC6L", "ERMP1", "ERO1A", "ERO1B", "ESD", "ETFDH", "EWSR1", "EXD2", "EXO1", "EXOSC1", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC8", "EXOSC9", "EYA4", "F11R", "FADS2", "FAH", "FAHD1", "FAHD2A", "FAM120A", "FAM208A", "FAM213A", "FANCI", "FAR1", "FARP1", "FARP2", "FARSA", "FARSB", "FASN", "FASTKD5", "FBL", "FDFT1", "FDPS", "FDXR", "FECH", "FEN1", "FH", "FHL1", "FHOD1", "FIP1L1", "FKBP10", "FKBP14", "FKBP2", "FKBP3", "FKBP4", "FKBP5", "FKBP7", "FKBP8", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FMR1", "FNTA", "FNTB", "FOXC1", "FOXK1", "FOXRED1", "FSCN1", "FTO", "FTSJ3", "FUBP1", "FUBP3", "FUCA1", "FUCA2", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GADD45GIP1", "GAK", "GALK1", "GALM", "GALNS", "GALNT1", "GALNT2", "GALNT4", "GALNT7", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GATAD2B", "GATB", "GBA", "GBF1", "GCAT", "GCDH", "GCLC", "GCN1", "GDI1", "GDI2", "GDPD1", "GEMIN5", "GFM1", "GFPT1", "GGCT", "GGCX", "GGH", "GGT7", "GLA", "GLB1", "GLCE", "GLDC", "GLO1", "GLS", "GLUD1", "GLYR1", "GM2A", "GMFB", "GMPS", "GNA13", "GNAI1", "GNAI2", "GNAI3", "GNAQ", "GNE", "GNG12", "GNG5", "GNPAT", "GNPDA1", "GNPNAT1", "GNS", "GOT1", "GOT2", "GPAM", "GPAT4", "GPD1L", "GPD2", "GPHN", "GPI", "GPKOW", "GPR89B", "GPT2", "GPX8", "GRHPR", "GRPEL1", "GRSF1", "GSK3B", "GSR", "GSS", "GSTK1", "GSTM3", "GSTO1", "GSTZ1", "GTF2E2", "GTF2F1", "GTF2I", "GTF3C1", "GTF3C3", "GTF3C4", "GTF3C5", "GUF1", "GXYLT1", "GYG1", "GYS1", "H1F0", "H1FX", "H2AFY", "H2AFY2", "H4C1*", "HACD3", "HACL1", "HADH", "HADHA", "HADHB", "HARS2", "HAT1", "HBS1L", "HCCS", "HCFC1", "HDAC1", "HDAC2", "HDGF", "HDGFL3", "HDLBP", "HEATR1", "HECTD1", "HECTD3", "HELLS", "HEXA", "HEXB", "HIBADH", "HIBCH", "HINT2", "HINT3", "HIRA", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLTF", "HM13", "HMBS", "HMCES", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMGCL", "HMGCR", "HMGCS1", "HMGN2", "HMOX1", "HMOX2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPLL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HP1BP3", "HPRT1", "HS2ST1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSD17B7", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA14", "HSPA1B", "HSPA2", "HSPA4L", "HSPA8", "HSPA9", "HSPD1", "HSPE1", "HTATSF1", "HUWE1", "HYOU1", "IARS", "IARS2", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDI1", "IFIT5", "IGBP1", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IKBKB", "ILF2", "ILF3", "ILK", "ILKAP", "ILVBL", "IMP3", "IMP4", "IMPAD1", "IMPDH1", "IMPDH2", "INA", "INF2", "INPP4A", "INPPL1", "INTS11", "IQCB1", "IQGAP1", "IQGAP3", "IRF2BPL", "IRS4", "ISG20L2", "ISYNA1", "ITCH", "ITGB1", "ITPA", "ITPK1", "IVD", "JMJD6", "KARS", "KAT7", "KDELC2", "KDELR1", "KDM1A", "KDM1B", "KDM2A", "KDM3B", "KDM5A", "KDSR", "KHDRBS1", "KHDRBS3", "KHSRP", "KIAA0391", "KIAA1147", "KIF11", "KIF14", "KIF18A", "KIF18B", "KIF1A", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF3A", "KIF4A", "KIF5B", "KIFBP", "KIN", "KLC1", "KLC4", "KMT2A", "KRR1", "KYAT3", "L2HGDH", "L3HYPDH", "LACTB", "LAMP1", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LASP1", "LBR", "LCLAT1", "LDAH", "LDHA", "LDHB", "LDLR", "LEMD3", "LGALS3", "LGMN", "LIG1", "LIG3", "LIMA1", "LIPA", "LNPEP", "LNPK", "LONP1", "LPCAT1", "LPGAT1", "LRP1", "LRPAP1", "LRPPRC", "LRRC8C", "LRSAM1", "LRWD1", "LSM14B", "LSM2", "LSM4", "LSM6", "LSM7", "LSS", "LTA4H", "LTN1", "LUC7L3", "LYAR", "LYN", "LYPLA1", "M6PR", "MACF1", "MAEA", "MAGED2", "MALT1", "MAN2A1", "MAN2B1", "MANF", "MAP1S", "MAPK1", "MAPK14", "MARC1", "MARCH5", "MARS", "MARS2", "MAT2A", "MATR3", "MBD3", "MBOAT7", "MCCC1", "MCCC2", "MCL1", "MCM10", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCU", "MDH1", "MDH2", "MDN1", "ME1", "ME2", "MECP2", "MED14", "MED17", "MED22", "MED23", "MED24", "MED4", "MEPCE", "MESD", "METAP1", "METAP2", "METTL13", "METTL3", "METTL7B", "METTL9", "MFN1", "MFN2", "MGEA5", "MGST2", "MGST3", "MIF", "MINDY3", "MINPP1", "MIPEP", "MKI67", "MKRN2", "MMAB", "MMS19", "MOCOS", "MOGS", "MORC2", "MORF4L1", "MORF4L2", "MOV10", "MPG", "MPHOSPH10", "MPHOSPH6", "MPHOSPH8", "MPI", "MPRIP", "MPST", "MRC2", "MRE11", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL14", "MRPL15", "MRPL17", "MRPL19", "MRPL2", "MRPL20", "MRPL21", "MRPL22", "MRPL24", "MRPL28", "MRPL3", "MRPL37", "MRPL38", "MRPL39", "MRPL40", "MRPL41", "MRPL43", "MRPL44", "MRPL46", "MRPL47", "MRPL48", "MRPL49", "MRPL50", "MRPL53", "MRPL58", "MRPL9", "MRPS11", "MRPS16", "MRPS18A", "MRPS22", "MRPS23", "MRPS25", "MRPS27", "MRPS28", "MRPS30", "MRPS31", "MRPS33", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRPS9", "MSH2", "MSH3", "MSH6", "MSI1", "MSI2", "MSMO1", "MTA1", "MTA2", "MTAP", "MTHFD1L", "MTHFD2", "MTHFS", "MTMR14", "MTMR2", "MTMR6", "MTOR", "MTPAP", "MTR", "MUL1", "MUT", "MVD", "MYBBP1A", "MYCBP2", "MYG1", "MYH10", "MYH14", "MYH9", "MYL6", "MYO18A", "MYO1B", "MYO1C", "MYO1D", "MYO6", "NAA10", "NAA15", "NAA40", "NAA50", "NAF1", "NAGLU", "NAMPT", "NANS", "NAP1L4", "NARS", "NAT10", "NAXE", "NCBP3", "NCEH1", "NCL", "NCOA5", "NCOR1", "ND1", "NDUFAF2", "NDUFAF4", "NDUFAF7", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS7", "NDUFS8", "NDUFV1", "NDUFV2", "NEDD4L", "NEK9", "NELFA", "NELFCD", "NELFE", "NES", "NF1", "NFS1", "NHP2", "NIFK", "NIP7", "NIPBL", "NISCH", "NIT2", "NKRF", "NKTR", "NLN", "NME1", "NME2", "NMT1", "NNT", "NOB1", "NOC2L", "NOL11", "NOL6", "NOL8", "NOL9", "NONO", "NOP2", "NOP56", "NOP58", "NOP9", "NOSIP", "NOTCH2", "NPC1", "NPEPPS", "NPLOC4", "NPM1", "NRDC", "NRP1", "NSA2", "NSD1", "NSD2", "NSD3", "NSDHL", "NSF", "NSMCE2", "NSUN2", "NT5C2", "NT5C3A", "NT5C3B", "NT5DC1", "NT5DC2", "NTHL1", "NTMT1", "NTPCR", "NUCB1", "NUCB2", "NUDCD1", "NUDT1", "NUDT16L1", "NUDT21", "NUDT5", "NUFIP2", "NUP153", "NUP98", "NUSAP1", "NXF1", "NXN", "OARD1", "OAT", "OCRL", "OGDH", "OGFOD3", "OGT", "OLA1", "OPA1", "ORC3", "OSGEP", "OTUB1", "OXSR1", "P3H1", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PAFAH1B1", "PAFAH1B2", "PAFAH1B3", "PAICS", "PAK1IP1", "PAK2", "PALLD", "PANK4", "PAPOLA", "PAPSS1", "PARG", "PARK7", "PARN", "PARP1", "PARP2", "PATL1", "PBK", "PBRM1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCMT1", "PCNA", "PCYOX1", "PDCL3", "PDE12", "PDHA1", "PDHB", "PDIA3", "PDIA4", "PDIA6", "PDK1", "PDK3", "PDP1", "PDSS2", "PDXDC1", "PEBP1", "PECR", "PELO", "PELP1", "PEPD", "PFAS", "PFDN2", "PFDN4", "PFDN5", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGM3", "PGP", "PGRMC1", "PGRMC2", "PHB2", "PHF2", "PHF5A", "PHF6", "PHGDH", "PHKA1", "PHKB", "PI4K2A", "PI4KA", "PI4KB", "PIGG", "PIGK", "PIK3C2A", "PIK3R4", "PIN1", "PIN4", "PIP4K2C", "PIR", "PISD", "PITHD1", "PITRM1", "PKM", "PKMYT1", "PKN1", "PKN2", "PLA2G15", "PLAA", "PLBD2", "PLCG1", "PLD3", "PLD6", "PLEC", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLS3", "PLXNB2", "PMPCB", "PMVK", "PNKP", "PNN", "PNO1", "PNP", "PNPLA6", "PNPLA8", "PNPT1", "POFUT1", "POGZ", "POLA1", "POLD1", "POLDIP3", "POLE", "POLE2", "POLG", "POLR1A", "POLR1B", "POLR2B", "POLR2G", "POLR3A", "POLR3B", "POLR3C", "POLRMT", "PON2", "POP1", "POP4", "POR", "PPA1", "PPA2", "PPAT", "PPCDC", "PPHLN1", "PPIB", "PPIC", "PPID", "PPIE", "PPIF", "PPIG", "PPIH", "PPIL4", "PPM1G", "PPME1", "PPOX", "PPP1CA", "PPP1CB", "PPP1R10", "PPP1R8", "PPP3CA", "PPP5C", "PPP6C", "PPT1", "PPWD1", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PREP", "PREPL", "PRIM1", "PRIM2", "PRKAA1", "PRKAA2", "PRKACA", "PRKCB", "PRKDC", "PRMT1", "PRMT3", "PRMT5", "PRMT9", "PRPF19", "PRPF31", "PRPF4B", "PRPF8", "PRPS2", "PSAT1", "PSIP1", "PSMB5", "PSMB6", "PSMB7", "PSMD10", "PSMD14", "PSME4", "PSMG1", "PSMG2", "PSMG3", "PSPC1", "PTBP1", "PTBP2", "PTCD3", "PTDSS1", "PTDSS2", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK2", "PTK7", "PTPA", "PTPN1", "PTPN11", "PTPN23", "PTPRF", "PTRH2", "PUF60", "PUM3", "PURA", "PUS1", "PUS7", "PUS7L", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QDPR", "QKI", "QRSL1", "QSOX2", "RAB10", "RAB18", "RAB1A", "RAB1B", "RAB23", "RAB3GAP1", "RAB3GAP2", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RABGAP1", "RABGGTA", "RAC1", "RACGAP1", "RACK1", "RAD18", "RAD21", "RAD50", "RAD54L2", "RALA", "RALY", "RANBP1", "RANBP2", "RANGAP1", "RAP1GDS1", "RAPGEF2", "RARS", "RARS2", "RAVER1", "RBBP4", "RBBP5", "RBBP6", "RBBP7", "RBM10", "RBM12", "RBM12B", "RBM14", "RBM17", "RBM19", "RBM22", "RBM25", "RBM26", "RBM27", "RBM28", "RBM3", "RBM34", "RBM39", "RBM4", "RBM45", "RBM47", "RBM5", "RBM6", "RBM8A", "RBMX", "RBMXL1", "RBPJ", "RCC1", "RCC2", "RDH11", "RDH13", "RDH14", "RDX", "RECQL", "RETSAT", "REXO2", "REXO4", "RFC1", "RFC3", "RHOT1", "RHOT2", "RIDA", "RIPK1", "RNASEH2A", "RNASET2", "RNF2", "RNF20", "RNF40", "RNMT", "RNPEP", "RNPS1", "ROBO1", "ROCK1", "ROCK2", "RP2", "RPA1", "RPA2", "RPAP1", "RPF1", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPP30", "RPP38", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS26", "RPS28", "RPS29", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RPUSD3", "RRAS2", "RREB1", "RRM1", "RRM2", "RRP1B", "RRP8", "RRP9", "RSBN1", "RSF1", "RTCA", "RTCB", "RTRAF", "RUVBL1", "RUVBL2", "SACM1L", "SAE1", "SAFB", "SAFB2", "SALL2", "SAMD4B", "SAMHD1", "SAP130", "SAP18", "SAP30BP", "SARM1", "SARNP", "SARS", "SARS2", "SART3", "SCAF1", "SCAF4", "SCARB1", "SCARB2", "SCCPDH", "SCD", "SCML2", "SCO1", "SCO2", "SCP2", "SCPEP1", "SCRIB", "SCYL1", "SDHA", "SDHB", "SDR39U1", "SEC11A", "SEC61A1", "SEC63", "SENP3", "SERBP1", "SERPINB6", "SERPINH1", "SET", "SETD1A", "SETD2", "SETD3", "SETDB1", "SF1", "SF3B1", "SF3B4", "SF3B6", "SFPQ", "SFSWAP", "SGF29", "SGPL1", "SGTA", "SHMT1", "SHMT2", "SHTN1", "SIGMAR1", "SIN3A", "SKIV2L", "SKIV2L2", "SLC1A5", "SLC27A4", "SLC7A1", "SLFN11", "SLIRP", "SLIT2", "SLK", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMCHD1", "SMG1", "SMN1*", "SMPD4", "SMS", "SND1", "SNRNP200", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPC", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNU13", "SOAT1", "SOD2", "SON", "SORD", "SORT1", "SPATA5", "SPCS2", "SPCS3", "SPEN", "SPOUT1", "SPPL2A", "SPR", "SPTAN1", "SPTBN1", "SPTLC1", "SPTLC2", "SQLE", "SRC", "SRCAP", "SRM", "SRP14", "SRP54", "SRP68", "SRP72", "SRP9", "SRPK1", "SRPK2", "SRPRA", "SRPRB", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF3", "SRSF4", "SRSF5", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSRP1", "STAT1", "STAT3", "STAU1", "STAU2", "STK26", "STK3", "STK4", "STMN1", "STRBP", "STRN", "STT3A", "STT3B", "STUB1", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUPT3H", "SUPT5H", "SUPT6H", "SUPV3L1", "SURF6", "SUZ12", "SYNCRIP", "SYNE1", "SYNE2", "TAF15", "TALDO1", "TAMM41", "TAP1", "TAP2", "TARBP1", "TARDBP", "TARS", "TARS2", "TARSL2", "TBC1D13", "TBC1D15", "TBC1D4", "TBC1D9B", "TBCA", "TBCB", "TBCD", "TBCE", "TBL1XR1", "TCEA1", "TCERG1", "TCP1", "TDRKH", "TECR", "TERF2IP", "TFAM", "TFB1M", "TFCP2", "TFRC", "THAP11", "THOC1", "THOC2", "THOC3", "THOC5", "THOC6", "THOP1", "THRAP3", "TIA1", "TIAL1", "TIGAR", "TIMM50", "TIMM8B", "TJP1", "TK1", "TKT", "TLE3", "TLK2", "TMCO1", "TMEM109", "TMLHE", "TMOD3", "TMPPE", "TMTC3", "TMX3", "TOMM22", "TOMM34", "TOMM40", "TOP1", "TOP2A", "TOP2B", "TOPBP1", "TOR1A", "TOR1B", "TOX4", "TP53", "TP53BP1", "TPI1", "TPM3", "TPM4", "TPP1", "TPP2", "TRA2A", "TRA2B", "TRAF2", "TRAP1", "TRIM13", "TRIM21", "TRIM25", "TRIM26", "TRIM27", "TRIM28", "TRIM33", "TRIM4", "TRIO", "TRIP12", "TRIR", "TRMT1", "TRMT10C", "TRMT11", "TRMT1L", "TRMT2A", "TRMU", "TROVE2", "TRRAP", "TRUB1", "TSFM", "TSN", "TSNAX", "TST", "TTF2", "TTK", "TTYH3", "TUFM", "TWF2", "TWNK", "TXNDC12", "TXNRD1", "TYMS", "U2AF1", "U2AF2", "U2SURP", "UAP1", "UBA1", "UBA2", "UBA3", "UBA6", "UBE2J1", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2O", "UBE2S", "UBE3A", "UBE3C", "UBE4A", "UBLCP1", "UBR2", "UBR4", "UBR5", "UBTF", "UCHL5", "UCK2", "UFL1", "UGCG", "UGDH", "UGGT1", "UGP2", "UGT8", "UHRF1", "UMPS", "UNC45A", "UPF1", "UPF2", "UPF3B", "UQCRFS1", "UROD", "USP10", "USP11", "USP14", "USP19", "USP24", "USP28", "USP36", "USP47", "USP48", "USP5", "USP7", "USP9X", "UTP3", "UTRN", "VANGL2", "VARS1", "VARS2", "VAT1", "VBP1", "VCL", "VCP", "VDAC1", "VDAC2", "VDAC3", "VIRMA", "VPS4A", "VPS4B", "VRK1", "WARS", "WDHD1", "WDR1", "WDR18", "WDR43", "WDR5", "WLS", "WRNIP1", "WTAP", "XPNPEP1", "XPNPEP3", "XPO1", "XPO5", "XPOT", "XRCC5", "XRCC6", "XRN2", "XXYLT1", "YARS", "YARS2", "YEATS4", "YKT6", "YLPM1", "YME1L1", "YOD1", 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sha256:f7fdffb3f722026b4b9e161236611f33038893f10eaf73a50b85b0f652be85f2 +size 98172 diff --git a/protein_atlas_protein_class/df_merge.tsv b/protein_atlas_protein_class/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..3ce7ae2525f94e677a73b668857325ed0a3936d8 --- /dev/null +++ b/protein_atlas_protein_class/df_merge.tsv @@ -0,0 +1,3 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Predicted membrane proteins 330 586 4.389930783433686 1.1338674633876169e-05 204.61650485436897 563.8058252427185 3.080866334016093 0.3028099075873978 81.17076282318972 73.52280648113661 4.068861305085399 0.4187410497068249 5.8500750064331325e-62 6.444806641834489e-11 3.0953347408935643e-22 1.870627976099217e-49 1.1516718998462222e-61 +Metabolic proteins 222 904 2.1682441673593367 0.0301401139661894 167.96116504854368 885.0898058252427 0.3517504365488901 0.4992811695371688 49.08590099318301 81.73901275864796 1.4937513760737942 0.4046478208580187 2.172324415629645e-09 0.1431198280295806 0.011319117392715 1.0944471897946334e-06 4.0102216355679426e-10 diff --git a/protein_atlas_protein_class/metrics.json b/protein_atlas_protein_class/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..57b2d38b18f50767c7ea0b751653dfac627b2893 --- /dev/null +++ b/protein_atlas_protein_class/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3221, + "annotations_size": 20, + "title": "Average number of proteins per term", + "value": 515.95 +} \ No newline at end of file diff --git a/protein_atlas_protein_class/paths.json b/protein_atlas_protein_class/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..86ee441cfbf2aeec6e331b1d151e1c90a72dd8cd --- /dev/null +++ b/protein_atlas_protein_class/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/protein_atlas_protein_class/fragment/C201/C201_val_log2fc"} \ No newline at end of file diff --git a/protein_atlas_protein_class/result.tsv b/protein_atlas_protein_class/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..9cab4141f79e265ea8e972bbf30cfde795de4cdd --- /dev/null +++ b/protein_atlas_protein_class/result.tsv @@ -0,0 +1,9 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Predicted membrane proteins 0.6905899884192636 4.389930783433686 1.1338674633876169e-05 0.0002267490668862 7.559116422584778e-05 586 Q9BSK2,Q3SXM5,Q6UW02,Q96PC5,Q9C0H2,Q07065,Q9H061,Q9H6V9,Q9NQC3,Q9NS69,Q9P2W9,Q9UDW1,Q9Y2R0,Q15800,O15127,P03886,O15173,O43169,O43657,O43676,O60637,O60725,O60830,O95070,O95197,P09601,P24390,P24539,P30519,P43307,Q13505,Q5VW38,Q96A26,P51648,Q86Y39,O95249,Q13423,Q16850,O95470,P57105,P35670,O15118,O95202,O75844,Q9Y282,Q16739,O43760,Q4ZIN3,O60499,Q8N8Q8,Q9NX40,Q70HW3,P13073,Q15070,P30825,O96005,Q9HD45,O75964,P51571,Q99720,Q14108,O60858,Q9H6K4,Q8N5M9,Q8N511,Q70UQ0,Q93050,Q9NX47,Q86YN1,Q9UBX3,Q8NCH0,Q9HCL2,Q9HD20,Q9NZJ7,Q9BUR5,O00461,Q96A33,O75071,Q8IV08,Q9Y487,O00264,P13473,P16260,Q5H8A4,Q9Y5M8,P46977,Q06136,O00400,P11117,Q15363,P38435,Q9H4I3,Q15392,Q9BT22,Q9NX62,Q92542,Q7KZN9,Q8NAN2,Q8N2H4,Q96G23,Q9UKU0,Q9H6H4,Q567V2,Q9UBV2,Q9GZP9,P16615,Q8WTV0,Q8WVC6,O14548,Q8N2A8,P42892,Q8TB61,Q9P035,Q9UJ14,Q5KU26,Q9NPA0,P27105,Q9NQX7,O43493,P51798,Q5SNT2,O76024,P67812,Q96JJ7,Q8NHH9,P11279,Q96J42,Q9H3K2,Q8TB36,Q96A57,Q14534,Q15043,Q16880,Q8TCT8,Q969V5,Q9Y3E0,Q15041,Q15125,Q92543,P51790,Q14739,Q8IXI1,Q9UG56,Q96CP7,O60831,Q8IWA4,P37268,P51572,Q5VV42,Q9H3N1,Q8NBX0,Q96KA5,Q92896,P04035,Q10472,Q96S66,Q08722,P35613,O75381,Q9Y619,Q8NF37,Q9P0J0,P57088,Q6ZT21,Q99640,Q96AA3,Q9NW15,Q07820,O15269,O43819,P05023,Q9NZ01,Q15005,O95674,O14925,P98194,Q96H78,Q9UIQ6,P50402,Q8IZA0,P00403,P05067,P39210,Q96ES6,Q9P0S9,Q9BTX1,Q9H2V7,Q12981,Q9BVG9,Q04656,O94919,P16435,Q5JRA6,P0CG08,Q9NR77,O15400,Q6UW68,O95168,Q53GQ0,P27824,Q5BJF2,Q6P4Q7,Q8NCG7,Q9Y2G8,Q7Z3C6,O75298,O14681,Q99735,Q9BVK6,P12236,Q13641,Q00765,P49755,Q15904,Q9NUT2,Q9NP58,Q7L0J3,O75880,P12235,O15258,Q6NTF9,Q96AQ8,Q9HC21,Q8IY95,Q9UH99,Q14728,Q8NBN3,Q9NX61,Q96N66,O75787,Q9Y6C9,Q92604,O95139,Q92643,Q9BU23,Q03519,P31350,Q96KC8,Q9BUN8,Q9Y320,Q86UE4,Q9NUQ2,Q14789,P50416,P48651,Q9UBM7,Q6NUQ4,Q8NE01,O95831,Q15388,P35573,Q96IX5,Q03518,P10321,P51812,Q9NTJ5,Q96HH6,Q16706,Q16799,O95140,P04920,Q96AG4,Q8TBQ9,A1L0T0,O75915,Q2TAA5,Q86Y82,Q969V3,Q8IZ83,Q9NVH1,P05141,Q86XL3,P20020,P55011,Q4KMQ2,Q5T9L3,Q9UM00,Q8TDW0,Q6ZRP7,Q5T8D3,P60228,Q9NRK6,P04439,P08574,P23634,Q6PIU2,Q99643,Q8TBA6,Q6P4A7,P04843,Q96CS3,Q5SWX8,Q16134,Q8IYS2,Q99442,Q9Y2W6,Q8TAA9,Q8WXH0,Q96PE3,Q8TCT9,Q15375,Q8N2K0,P54709,O00767,Q9H9B4,O75396,O43808,Q96S52,Q969X5,Q9NPR9,Q8N5B7,O75306,Q3ZCQ8,O14828,Q96FV9,Q9UPR3,Q8NE86,Q9Y289,Q8NHP6,P78310,Q9Y3D6,Q7Z2K6,P56589,Q96TA2,Q99567,Q9Y3B3,Q9UBG0,P53634,P28288,Q8N2F6 330 +Metabolic proteins 0.2920527106893398 2.1682441673593367 0.0301401139661894 0.4577744965914401 0.1004670465539647 904 O14949,O15498,P20674,Q96RU2,Q8N4Q0,Q8N6G5,P05141,Q9H2D1,P20020,Q9UDW1,O14773,P55011,Q15800,P03886,O43676,O60566,O60725,O00754,P50897,P07602,P09601,P43490,P17900,P24539,P30519,P08574,P13674,P23634,Q96L58,Q99643,Q13510,P51648,Q86Y39,Q13423,Q16850,O95470,Q9UHG3,O94923,P04843,O15118,Q9UKK9,O75844,O14578,Q16739,Q16134,Q70HW3,P13073,Q8NBQ5,Q9Y371,O75648,P30825,P04062,P46020,Q96PE3,O75964,Q9Y6M9,Q15375,P51571,Q8N2K0,P54709,O00767,P49366,Q9H000,Q93050,Q9NX47,Q86YN1,Q9H9B4,Q9UBX3,Q8NCH0,Q9HCL2,Q9BTU6,Q96AY3,O43808,Q96S52,Q8IV08,Q9Y487,P31751,Q8N5B7,P16260,Q13126,Q5H8A4,O15228,P46977,Q06136,O75306,P21964,P11413,O00400,P11117,Q15392,Q9BRR6,Q9BT22,Q9NX62,P35790,P54802,Q7LGA3,Q96G23,Q9UIJ7,Q9UKU0,P10619,P40939,P16615,Q8WTV0,Q96PU5,P22830,O43175,Q8N2A8,Q8TB61,Q9P035,Q9UJ14,P67812,Q96JJ7,Q9BQT8,P49354,Q14534,Q15043,Q16880,Q969V5,Q15125,Q14739,Q9UG56,P52888,Q9UJS0,P37268,P51572,Q8NBX0,Q9NPH0,P04035,Q53H12,Q10472,O15254,Q9Y680,Q9Y619,Q8NF37,Q9P0J0,Q9H9P8,P52789,Q6ZT21,Q99640,O15269,Q10713,P05023,P22695,Q9NZ01,Q15005,Q16836,O95674,P16278,P98194,P06280,P00403,O96028,Q9H7Z7,Q9BTX1,Q9BVG9,P16435,P48163,Q15165,Q5JRA6,O95168,Q53GQ0,Q9UPU5,Q8NCG7,P23786,Q99735,Q9NWM8,P12236,Q8NBN7,Q15904,Q9NVH6,Q9NP58,P10253,O00116,P53701,O43252,P12235,Q6UX53,O75962,P06576,Q9HC21,P56385,Q96N66,P09622,P06865,P53007,Q6UWE0,Q92604,O95139,Q92643,P10644,Q8N4A0,P31350,P09960,Q9NUQ2,P50416,O15460,P48651,Q9UBM7,Q7Z569,P35573,Q96IX5,O95299,O96000,P51812,Q14527,Q8NFH4,Q8TED1,Q9NTJ5,P21912,Q16706,Q8NFH5,O75746,P04920,P52788,P35269,Q6P2P2,Q9P0J1,P51970,Q08257,Q9BTY2,P14324,Q2TAA5 222 +Human disease related genes 0.279243293326291 1.8432127144230184 0.0652979592465476 0.7409021448247263 0.1620133692882655 924 O14949,Q9BXW9,Q9NQT5,Q9H061,P51530,Q86XL3,O14773,Q9UHX1,Q4KMQ2,Q15800,P03886,Q9UM00,Q8TDW0,O43676,O60566,O00754,P50897,P07602,P09601,P17900,P04439,P08574,Q16204,Q96L58,Q99643,Q13510,P51648,Q86Y39,Q6P4A7,Q13423,O95470,P35670,O15118,O95202,O75844,O14578,P02545,Q16134,Q69YQ0,Q70HW3,O75648,Q8TAA9,P04062,P46020,Q8WXH0,Q9Y6M9,O75208,P51571,Q99720,Q14108,Q9BRT2,Q8N2K0,Q9H6K4,P50148,P49366,Q8WWV3,Q8N511,Q5XKP0,O00165,Q9UBX3,Q8NCH0,Q96AY3,O00303,Q15233,Q96S52,Q9UEY8,Q8IV08,Q9Y487,Q969X5,P13473,P31751,O15228,Q5H8A4,O75306,P46977,Q06136,P11413,P21964,Q3ZCQ8,Q9Y6M1,Q4J6C6,O00400,P11117,P34059,P38435,Q15427,Q15392,Q9BT22,Q9NX62,Q13509,Q92542,Q7KZN9,P54802,P04899,P00374,P56589,P10619,P40855,P07099,P40939,Q96TA2,Q99567,P16615,Q96PU5,P22830,O43175,P42892,Q96CU9,Q9Y4P3,Q12768,P51798,O76024,Q01105,Q8TB36,Q9BQT8,Q15043,O75503,P08670,Q15041,Q15125,Q14739,Q9UJS0,P51572,Q5VV42,Q53H12,O75381,Q9Y619,Q9P0J0,Q9NVI7,Q9H9P8,Q96AA3,Q99797,Q9NW15,O15269,O43819,Q10713,P05023,P22695,Q9NZ01,Q16836,Q96RL7,P16278,P98194,Q6NUK1,P50402,P06280,P00403,O96028,P05067,P39210,Q9H7Z7,Q04656,P16435,P20700,Q9NR77,P61916,Q6P4Q7,Q9Y2G8,O75298,Q15645,P23786,Q9UBB4,Q9NWM8,P04637,Q9NVH6,Q9NP58,P10253,O75880,O00116,P53701,P12235,O75962,O00203,O60313,Q9HC21,P07196,Q9Y296,Q96N66,O75787,P09622,P06865,P53007,Q6UWE0,Q92643,P10644,Q03519,Q9Y320,O14656,Q03252,P50416,O15460,P48651,Q9UBM7,O95831,P57678,P35573,Q96IX5,Q8TD16,Q03518,P10321,O95299,O00584,O96000,P51812,Q8NFH4,Q9BPX6,Q99828,P21912,P33991,Q13144,Q96HY6,Q9Y263,O95140,O75746,O14979,P52788,O94905,P38398,Q9P0J1,P14324,Q2TAA5 221 +Transporters 0.5583178038111286 1.5830441478031607 0.1134114023249024 0.9099584771200786 0.2268228046498048 373 Q9BSK2,Q969V3,P20674,Q96PC5,Q9C0H2,Q07065,Q9H061,Q9H2D1,P05141,P20020,P55011,Q4KMQ2,O15127,Q5T9L3,Q9UM00,Q8TDW0,O60637,Q5T8D3,Q12959,P07602,Q9NRK6,P24390,P04439,P45880,P23634,Q99643,Q5VW38,Q8TBA6,Q6P4A7,P57105,P35670,O15118,O95202,O75844,Q16739,Q8N8Q8,Q70HW3,P13073,Q9Y371,Q15070,P30825,O96005,Q99720,Q14108,Q8N511,Q93050,Q9UBX3,Q9HD20,Q9NZJ7,Q9BUR5,Q96A33,P13473,P16260,P46977,O00400,Q15363,P40855,Q9UBV2,Q9GZP9,P16615,Q8WTV0,Q8TB61,Q9NPA0,P27105,P51798,Q6KCM7,O76024,Q96JJ7,Q8NHH9,P11279,Q9BQT8,Q8TEX9,Q96A57,Q15043,Q8TCT8,O60831,Q8IWA4,Q9UJS0,P51572,Q9H3N1,P04035,Q96S66,Q08722,P35613,O75381,Q9Y619,O43681,P57088,Q96AA3,Q9NW15,P05023,Q96RL7,P98194,Q6NUK1,Q96H78,Q9Y512,Q16891,P00403,P05067,P39210,Q9BTX1,Q9H2V7,Q04656,Q5JRA6,Q9NR77,Q6UW68,O95433,P61916,Q5BJF2,Q6P4Q7,Q7Z3C6,O14681,Q96L92,P12236,Q567U6,P49755,P04637,Q15904,Q9NUT2,Q9NP58,O75955,P12235,O15258,Q6NTF9,O60313,Q9HC21,Q8IY95,Q9UH99,Q96N66,Q15006,O75787,P53007,Q9Y6C9,Q03519,Q9BUN8,Q9Y320,Q9C0E2,Q9NRR5,P50416,O96008,Q9BRK5,Q8NE01,P52292,Q03518,Q8NFH4,Q9BPX6,Q99828,P21912,Q8NFH5,Q16799,O95140,O75746,P04920,Q96AG4,O94905,O75915 156 +Predicted secreted proteins 0.3968228171986487 1.330403352850444 0.1833854104770085 0.9826082736246536 0.3111103429062449 52 Q9HB40,Q6P179,Q15165,Q9NZ08,Q9Y4P3,Q02818,Q9UM22,P05067,Q9BUR5,Q8N128,P80303,O94919 12 +CD markers 0.4592264867336005 1.1632165609475609 0.2447416489594589 0.9963532102871944 0.3615861585126 17 P11279,O75330,P13473,Q08722,P35613,P54709 6 +Disease related genes 0.2573348467750267 1.0890928740177963 0.2761129320114293 0.998438951618611 0.368150576015239 1037 O14949,P20674,Q9BXW9,Q9NQT5,Q96PC5,Q9H061,Q9H2D1,P51530,Q86XL3,O14773,Q9UHX1,Q9Y2R0,Q15800,Q4KMQ2,P03886,Q9UM00,O43676,O60566,Q5T8D3,O00754,P50897,P07602,P09601,P17900,P23246,O43572,P04439,P08574,Q16204,Q96L58,Q99643,Q8TBA6,Q13510,P51648,Q86Y39,O95684,Q13423,O95470,P35670,O15118,O75844,P02545,Q70HW3,P13073,P04062,Q9Y6M9,O75208,P51571,Q99720,Q14108,Q9H6K4,Q8N5M9,Q8WWV3,Q8N511,Q5XKP0,O00165,Q8NCH0,Q96A33,Q8IV08,Q9Y487,P13473,Q13126,Q5H8A4,P46977,Q06136,P21964,O00400,P11117,P38435,Q15392,Q9BT22,Q9NX62,Q92542,Q7KZN9,P54802,Q9UKU0,P10619,P40855,P40939,P16615,Q96PU5,P22830,O43175,P42892,Q96CU9,Q9Y4P3,Q12768,P51798,O76024,Q01105,Q96J42,Q8TB36,Q9BQT8,Q15043,O75503,P08670,Q15041,Q15125,Q14739,Q9UJS0,P37268,P51572,Q5VV42,Q53H12,Q96S66,O75381,Q9Y619,Q9P0J0,Q9NVI7,Q9H9P8,Q96AA3,Q5HYI8,Q99797,Q9NW15,O15269,O43819,Q10713,P05023,P22695,Q9NZ01,Q16836,Q96RL7,P16278,P98194,Q6NUK1,P50402,P06280,P00403,O96028,P05067,P39210,Q04656,P16435,P20700,P61916,Q6P4Q7,O75298,Q15645,O14681,P23786,Q9UBB4,Q9NWM8,P04637,Q15904,Q9NVH6,Q9NP58,P10253,O75880,O00116,P53701,P12235,O75962,O00203,O60313,Q9HC21,P07196,Q9Y296,Q96N66,O75787,P09622,P06865,P53007,Q6UWE0,Q92643,P10644,Q03519,Q9Y320,O14656,Q03252,Q9NRR5,P50416,O15460,P48651,Q9UBM7,O95831,P57678,P35573,Q96IX5,Q8TD16,Q03518,P10321,O95299,O00584,P51812,Q8NFH4,Q9BPX6,Q99828,P21912,P33991,Q13144,Q96HY6,Q9Y263,O95140,O75746,O14979,P52788,O94905,P38398,Q9P0J1,P14324,Q2TAA5 201 +FDA approved drug targets 0.3512332082049912 0.675146722928016 0.4995825514408509 0.9999990302743452 0.587744178165707 118 P38435,P05141,P20020,P55011,O75330,P05023,P03886,Q16836,P16615,P98194,P31350,P23634,P05067,P50416,Q13423,Q16850,Q16739,P49354,Q14534,Q99720,P49721,P23786,P12236,Q7L0J3,P10253,P04035,P12235,P14324,P21964 29 diff --git a/protein_atlas_protein_class/selections.json b/protein_atlas_protein_class/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..6a2f2e4c8d9a0b967f9f440af071a4d1d6b6e00b --- /dev/null +++ b/protein_atlas_protein_class/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["Blood group antigen proteins", "CD markers", "Cancer-related genes", "Candidate cardiovascular disease genes", "Citric acid cycle related proteins", "Disease related genes", "Enzymes", "FDA approved drug targets", "Human disease related genes", "Metabolic proteins", "Plasma proteins", "Potential drug targets", "Predicted intracellular proteins", "Predicted membrane proteins", "Predicted secreted proteins", "RAS pathway related proteins", "RNA polymerase related proteins", "Ribosomal proteins", "Transcription factors", "Transporters"], "available_proteins": ["AAAS", "AAR2", "AARS", "AARS2", "AASDHPPT", "AASS", "AATF", "ABCB1", "ABCB10", "ABCB6", "ABCB7", "ABCB8", "ABCC4", "ABCD3", "ABCE1", "ABCF1", "ABCF2", "ABCF3", "ABHD10", "ABHD12", "ABHD14B", "ABHD6", "ABRACL", "ABRAXAS2", "ACAA1", "ACAA2", "ACACA", "ACACB", "ACAD11", "ACAD9", "ACADM", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACBD5", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT8", "ACOT9", "ACOX1", "ACOX3", "ACP1", "ACP2", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACSL6", "ACTL6A", "ACTN1", "ACTN4", "ACTR1A", "ACTR1B", "ACTR2", "ACTR3", "ACTR8", "ADA", "ADAR", "ADD1", "ADD3", "ADH5", "ADI1", "ADK", "ADNP", "ADPGK", "ADRM1", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGK", "AGL", "AGPAT1", "AGPAT5", "AGPS", "AHCTF1", "AHCY", "AHCYL1", "AHNAK", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AK3", "AK4", "AK6", "AKAP1", "AKAP10", "AKAP8", "AKAP8L", "AKAP9", "AKR1A1", "AKR1B1", "AKR7A2", "AKT2", "ALDH16A1", "ALDH18A1", "ALDH1A2", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALG1", "ALG11", "ALG5", "ALKBH5", "AMOT", "ANAPC1", "ANAPC16", "ANAPC2", "ANAPC4", "ANAPC5", "ANAPC7", "ANGEL1", "ANK3", "ANKFY1", "ANKHD1", "ANKLE2", "ANKRD17", "ANLN", "ANO10", "ANO6", "ANP32A", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA4", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP1M1", "AP1S1", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "APEH", "APEX1", "API5", "APMAP", "APOO", "APOOL", "APP", "APPL1", "APRT", "AQR", "ARCN1", "ARF4", "ARF6", "ARFGAP1", "ARFIP1", "ARFIP2", "ARG2", "ARGLU1", "ARHGAP17", "ARHGDIA", "ARHGEF2", "ARID1A", "ARID2", "ARID3B", "ARIH2", "ARL1", "ARL2", "ARL3", "ARL6IP1", "ARL6IP5", "ARL8A", "ARMC1", "ARMC10", "ARMC6", "ARMCX3", "ARMT1", "ARPC1A", "ARPC2", "ARPC3", "ARPC4", "ARVCF", "ASAH1", "ASB6", "ASCC2", "ASCC3", "ASH2L", "ASNA1", "ASNS", "ASPH", "ASPSCR1", "ATAD1", "ATAD2", "ATAD3A", "ATAD3B", "ATAD5", "ATG3", "ATG9A", "ATIC", "ATL2", "ATP13A1", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP2B4", "ATP2C1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6AP1", "ATP6AP2", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1D", "ATP6V1E1", "ATP6V1H", "ATP7A", "ATP7B", "ATPAF1", "ATPIF1", "ATRIP", "ATXN10", "ATXN2L", "AUP1", "AURKA", "B3GALT6", "B4GAT1", "BABAM1", "BABAM2", "BAG2", "BAG3", "BAG4", "BAG5", "BAG6", "BAIAP2", "BANF1", "BAP18", "BARD1", "BASP1", "BAZ1A", "BAZ1B", "BAZ2A", "BCAP31", "BCAS2", "BCAS3", "BCCIP", "BCKDK", "BCL2L12", "BCLAF1", "BCR", "BCS1L", "BICD2", "BIRC6", "BLM", "BLMH", "BLVRA", "BMS1", "BNIP1", "BOLA2*", "BOP1", "BPNT1", "BPTF", "BRAP", "BRCA1", "BRD1", "BRD2", "BRD4", "BRIX1", "BRMS1L", "BSG", "BTAF1", "BTF3", "BUB1B", "BUB3", "BUD23", "BUD31", "BYSL", "BZW1", "BZW2", "C12orf73", "C17orf75", "C19orf25", "C19orf70", "C1QBP", "C1orf123", "C1orf35", "C2CD5", "C2orf49", "C4orf46", "C5orf51", "C8orf33", "C9orf64", "CAB39", "CACYBP", "CAD", "CALD1", "CALR", "CALU", "CAMK2G", "CAMSAP3", "CAND1", "CAND2", "CANT1", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPNS1", "CAPRIN1", "CAPZA1", "CAPZB", "CARHSP1", "CARS", "CASK", "CAST", "CBR1", "CBX1", "CBX2", "CBX3", "CBX5", "CBX8", "CC2D1A", "CCAR1", "CCAR2", "CCDC134", "CCDC138", "CCDC22", "CCDC47", "CCDC59", "CCDC6", "CCDC86", "CCDC93", "CCDC97", "CCNB1", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2AP", "CD2BP2", "CD3EAP", "CD47", "CDC123", "CDC16", "CDC23", "CDC27", "CDC37", "CDC42", "CDC5L", "CDC73", "CDCA2", "CDCA5", "CDCA7L", "CDCA8", "CDH2", "CDIPT", "CDK1", "CDK12", "CDK2", "CDK4", "CDK5", "CDK5RAP1", "CDK5RAP3", "CDK6", "CDK9", "CDKAL1", "CDKN2AIP", "CDS2", "CEBPZ", "CELF1", "CELF2", "CENPB", "CENPI", "CENPP", "CENPV", "CEP170", "CEP44", "CEP55", "CEP72", "CERS2", "CERS5", "CETN2", "CFAP20", "CFL1", "CFL2", "CHAC2", "CHAF1A", "CHAF1B", "CHAMP1", "CHCHD3", "CHD1", "CHD1L", "CHD4", "CHD8", "CHDH", "CHERP", "CHID1", "CHKA", "CHMP2B", "CHMP3", "CHMP4B", "CHMP5", "CHMP7", "CHORDC1", "CHRAC1", "CHST14", "CHTF18", "CHTOP", "CIAPIN1", "CIB1", "CIP2A", "CIRBP", "CISD2", "CIT", "CIZ1", "CKAP2", "CKAP4", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLASP2", "CLCC1", "CLCN3", "CLCN7", "CLGN", "CLIC1", "CLINT1", "CLN5", "CLNS1A", "CLPB", "CLPP", "CLPTM1", "CLPTM1L", "CLPX", "CLSPN", "CLTA", "CLTB", "CLTC", "CLUH", "CMAS", "CMPK1", "CMTR1", "CNDP2", "CNN2", "CNN3", "CNNM3", "CNNM4", "CNOT1", "CNOT4", "CNOT9", "CNP", "COA3", "COA7", "COG2", "COG3", "COG5", "COG6", "COG7", "COIL", "COL4A3BP", "COLEC12", "COLGALT1", "COMMD8", "COMT", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS8", "COPZ1", "COQ8A", "COQ9", "CORO1B", "CORO1C", "CORO7", "COTL1", "COX15", "COX18", "COX2", "COX4I1", "COX5A", "COX5B", "COX6C", "COX7A2L", "CPD", "CPNE1", "CPNE2", "CPNE3", "CPNE8", "CPOX", "CPSF1", "CPSF2", "CPSF3", "CPSF6", "CPSF7", "CPT1A", "CPT2", "CPVL", "CRK", "CRKL", "CRNKL1", "CRTAP", "CRYZ", "CS", "CSDE1", "CSE1L", "CSGALNACT2", "CSK", "CSNK1A1", "CSNK2A1", "CSNK2A2", "CSNK2B", "CSRP2", "CSTB", "CSTF1", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTNNA1", "CTNNAL1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTPS2", "CTR9", "CTSA", "CTSC", "CTTN", "CTTNBP2NL", "CTU2", "CUL1", "CUL2", "CUL3", "CUL4A", "CUL4B", "CUL5", "CUTA", "CWC15", "CWC22", "CWF19L1", "CXADR", "CXorf56", "CXorf57", "CYB5B", "CYB5R1", "CYB5R3", "CYC1", "CYFIP1", "CYFIP2", "CYP20A1", "CYP51A1", "DAGLB", "DAP3", "DARS", "DARS2", "DAZAP1", "DBN1", "DBNL", "DBT", "DCAF1", "DCAF13", "DCAF7", "DCAF8", "DCAKD", "DCD", "DCP1B", "DCPS", "DCTD", "DCTN1", "DCTN2", "DCTN3", "DCTN4", "DCTPP1", "DCUN1D1", "DCUN1D5", "DCXR", "DDB1", "DDI2", "DDOST", "DDRGK1", "DDT", "DDX1", "DDX10", "DDX17", "DDX18", "DDX20", "DDX21", "DDX23", "DDX24", "DDX28", "DDX39A", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX50", "DDX51", "DDX52", "DDX54", "DDX56", "DDX6", "DEK", "DENND6A", "DENR", "DERL1", "DERL2", "DFFA", "DHCR24", "DHCR7", "DHFR", "DHPS", "DHRS1", "DHRS13", "DHRS7", "DHRS7B", "DHTKD1", "DHX15", "DHX16", "DHX29", "DHX30", "DHX36", "DHX37", "DHX38", "DHX40", "DHX57", "DHX8", "DHX9", "DIAPH1", "DIAPH2", "DIAPH3", "DICER1", "DIDO1", "DIEXF", "DIMT1", "DIS3", "DKC1", "DLAT", "DLD", "DLG1", "DLGAP5", "DLST", "DMAP1", "DNA2", "DNAAF5", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC13", "DNAJC16", "DNAJC2", "DNAJC21", "DNAJC3", "DNAJC7", "DNAJC8", "DNAJC9", "DNM1L", "DNM2", "DNMT1", "DNPH1", "DNTTIP2", "DOCK7", "DOHH", "DOLPP1", "DPF2", "DPH2", "DPH5", "DPM1", "DPP3", "DPP9", "DPY30", "DPYSL2", "DPYSL3", "DPYSL5", "DRG1", "DRG2", "DSC3", "DSCR3", "DSG2", "DSP", "DST", "DSTN", "DTX3L", "DTYMK", "DUS2", "DUSP12", "DUSP3", "DUSP9", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNC2H1", "DYNLL1", "DYNLL2", "EARS2", "EBNA1BP2", "EBP", "ECE1", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "ECSIT", "EDC3", "EDC4", "EDF1", "EDRF1", "EEA1", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EFCAB14", "EFL1", "EFTUD2", "EHBP1", "EHD1", "EHD4", "EI24", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2D", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E", "EIF4E2", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAC2", "ELAVL1", "ELL", "ELMO2", "ELMOD2", "ELOA", "ELOB", "ELP1", "ELP2", "ELP3", "ELP4", "EMC1", "EMC2", "EMC7", "EMD", "EMG1", "EML4", "ENAH", "ENDOD1", "ENO1", "ENO2", "ENY2", "EP400", "EPB41", "EPB41L2", "EPB41L3", "EPB41L5", "EPDR1", "EPHA7", "EPHX1", "EPHX2", "EPN1", "EPPK1", "EPRS", "EPS15L1", "ERAL1", "ERAP1", "ERAP2", "ERBIN", "ERC1", "ERCC2", "ERCC3", "ERCC6L", "ERG28", "ERGIC1", "ERGIC3", "ERH", "ERLIN1", "ERLIN2", "ERMP1", "ERO1A", "ERO1B", "ERP29", "ESD", "ESF1", "ESYT1", "ESYT2", "ETF1", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXD2", "EXO1", "EXOC2", "EXOC3", "EXOC5", "EXOC6", "EXOC7", "EXOC8", "EXOSC1", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC8", "EXOSC9", "EYA4", "EZR", "F11R", "FADS2", "FAF1", "FAF2", "FAH", "FAHD1", "FAHD2A", "FAM114A2", "FAM120A", "FAM129B", "FAM136A", "FAM162A", "FAM177A1", "FAM192A", "FAM208A", "FAM213A", "FAM49B", "FAM50A", "FAM98A", "FAM98B", "FANCD2", "FANCI", "FAR1", "FARP1", "FARP2", "FARSA", "FARSB", "FASN", "FASTKD5", "FBL", "FDFT1", "FDPS", "FDXR", "FECH", "FEN1", "FERMT2", "FGFR1OP", "FH", "FHL1", "FHOD1", "FIP1L1", "FIS1", "FKBP10", "FKBP14", "FKBP2", "FKBP3", "FKBP4", "FKBP5", "FKBP7", "FKBP8", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FMR1", "FNBP4", "FNDC3A", "FNTA", "FNTB", "FOCAD", "FOXC1", "FOXK1", "FOXRED1", "FRYL", "FSCN1", "FSD1", "FTO", "FTSJ3", "FUBP1", "FUBP3", "FUCA1", "FUCA2", "FUNDC2", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GADD45GIP1", "GAK", "GALK1", "GALM", "GALNS", "GALNT1", "GALNT2", "GALNT4", "GALNT7", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GATAD2B", "GATB", "GBA", "GBF1", "GCAT", "GCDH", "GCFC2", "GCLC", "GCN1", "GDAP1", "GDI1", "GDI2", "GDPD1", "GEMIN4", "GEMIN5", "GEMIN8", "GET4", "GFM1", "GFPT1", "GGA1", "GGCT", "GGCX", "GGH", "GGT7", "GHDC", "GHITM", "GID4", "GIGYF2", "GINS2", "GINS3", "GINS4", "GLA", "GLB1", "GLCE", "GLDC", "GLE1", "GLG1", "GLMN", "GLO1", "GLOD4", "GLRX3", "GLRX5", "GLS", "GLTP", "GLUD1", "GLYR1", "GM2A", "GMFB", "GMPS", "GNA13", "GNAI1", "GNAI2", "GNAI3", "GNAQ", "GNE", "GNG12", "GNG5", "GNL1", "GNL2", "GNL3", "GNL3L", "GNPAT", "GNPDA1", "GNPNAT1", "GNS", "GOLGA2", "GOLGA3", "GOLGA5", "GOLGB1", "GOLIM4", "GOLT1B", "GORASP2", "GOSR1", "GOT1", "GOT2", "GPAA1", "GPAM", "GPAT4", "GPATCH8", "GPD1L", "GPD2", "GPHN", "GPI", "GPKOW", "GPR107", "GPR108", "GPR89B", "GPRASP2", "GPS1", "GPT2", "GPX8", "GRB2", "GRHPR", "GRPEL1", "GRSF1", "GRWD1", "GSK3B", "GSPT1", "GSR", "GSS", "GSTK1", "GSTM3", "GSTO1", "GSTZ1", "GTF2E1", "GTF2E2", "GTF2F1", "GTF2H1", "GTF2H4", "GTF2I", "GTF3C1", "GTF3C2", "GTF3C3", "GTF3C4", "GTF3C5", "GTPBP1", "GTPBP10", "GTPBP3", "GTPBP4", "GUF1", "GXYLT1", "GYG1", "GYS1", "H1F0", "H1FX", "H2AFY", "H2AFY2", "H4C1*", "HACD3", "HACL1", "HADH", "HADHA", "HADHB", "HARS2", "HAT1", "HAUS1", "HAUS3", "HAUS4", "HAUS5", "HAUS6", "HAX1", "HBS1L", "HCCS", "HCFC1", "HDAC1", "HDAC2", "HDGF", "HDGFL2", "HDGFL3", "HDHD2", "HDHD5", "HDLBP", "HEATR1", "HEATR3", "HEATR6", "HEBP1", "HECTD1", "HECTD3", "HELLS", "HEXA", "HEXB", "HGH1", "HGS", "HIBADH", "HIBCH", "HINT2", "HINT3", "HIRA", "HIRIP3", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLTF", "HM13", "HMBS", "HMCES", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMGCL", "HMGCR", "HMGCS1", "HMGN2", "HMMR", "HMOX1", "HMOX2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPLL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HNRNPUL2", "HOOK2", "HOOK3", "HP1BP3", "HPRT1", "HPS6", "HS2ST1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSD17B7", "HSDL1", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA13", "HSPA14", "HSPA1B", "HSPA2", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPBP1", "HSPD1", "HSPE1", "HSPH1", "HTATSF1", "HTT", "HUWE1", "HYOU1", "IARS", "IARS2", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDH3G", "IDI1", "IFIT5", "IFT27", "IFT81", "IGBP1", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IK", "IKBIP", "IKBKB", "ILF2", "ILF3", "ILK", "ILKAP", "ILVBL", "IMMT", "IMP3", "IMP4", "IMPAD1", "IMPDH1", "IMPDH2", "INA", "INF2", "INPP4A", "INPPL1", "INTS1", "INTS11", "INTS14", "INTS2", "INTS3", "INTS4", "INTS7", "INTS8", "INTS9", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQCB1", "IQGAP1", "IQGAP3", "IRF2BPL", "IRGQ", "IRS4", "ISG20L2", "ISOC1", "IST1", "ISY1", "ISYNA1", "ITCH", "ITGB1", "ITM2C", "ITPA", "ITPK1", "ITSN2", "IVD", "IWS1", "JAGN1", "JMJD6", "JPT2", "JUP", "KARS", "KAT7", "KCTD12", "KDELC2", "KDELR1", "KDM1A", "KDM1B", "KDM2A", "KDM3B", "KDM5A", "KDSR", "KHDRBS1", "KHDRBS3", "KHSRP", "KIAA0319L", "KIAA0368", "KIAA0391", "KIAA1147", "KIAA1468", "KIAA2013", "KIDINS220", "KIF11", "KIF14", "KIF18A", "KIF18B", "KIF1A", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF3A", "KIF4A", "KIF5B", "KIFBP", "KIN", "KLC1", "KLC4", "KLHL11", "KMT2A", "KNOP1", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNA6", "KPNB1", "KRI1", "KRR1", "KTN1", "KYAT3", "L2HGDH", "L3HYPDH", "LACTB", "LAMB1", "LAMC1", "LAMP1", "LAMP2", "LAMTOR1", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LAS1L", "LASP1", "LBR", "LCLAT1", "LDAH", "LDHA", "LDHB", "LDLR", "LEMD3", "LETM1", "LGALS3", "LGALS3BP", "LGMN", "LIG1", "LIG3", "LIMA1", "LIN9", "LIPA", "LLGL1", "LLPH", "LMAN2", "LMAN2L", "LMF2", "LMNA", "LMNB1", "LMNB2", "LNPEP", "LNPK", "LONP1", "LPCAT1", "LPGAT1", "LRBA", "LRP1", "LRPAP1", "LRPPRC", "LRRC1", "LRRC40", "LRRC47", "LRRC57", "LRRC59", "LRRC8C", "LRSAM1", "LRWD1", "LSM12", "LSM14B", "LSM2", "LSM4", "LSM6", "LSM7", "LSS", "LTA4H", "LTN1", "LTV1", "LUC7L", "LUC7L2", "LUC7L3", "LYAR", "LYN", "LYPLA1", "LZTFL1", "M6PR", "MACF1", "MAEA", "MAGED2", "MAGT1", "MAIP1", "MAK16", "MALT1", "MAN2A1", "MAN2B1", "MANF", "MAP1A", "MAP1B", "MAP1S", "MAP4", "MAP7D1", "MAPK1", "MAPK14", "MAPRE1", "MAPRE2", "MARC1", "MARCH5", "MARS", "MARS2", "MAT2A", "MAT2B", "MATR3", "MAU2", "MAVS", "MBD3", "MBOAT7", "MCAM", "MCCC1", "MCCC2", "MCL1", "MCM10", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCMBP", "MCU", "MCUB", "MCUR1", "MDC1", "MDH1", "MDH2", "MDN1", "ME1", "ME2", "MECP2", "MED14", "MED17", "MED22", "MED23", "MED24", "MED4", "MEPCE", "MESD", "METAP1", "METAP2", "METTL13", "METTL3", "METTL7B", "METTL9", "MFN1", "MFN2", "MFSD10", "MFSD3", "MFSD5", "MGEA5", "MGST2", "MGST3", "MIA2", "MIA3", "MICU1", "MIEF1", "MIF", "MIGA1", "MINDY3", "MINPP1", "MIPEP", "MKI67", "MKLN1", "MKRN2", "MLEC", "MMAB", "MMS19", "MOCOS", "MOGS", "MON2", "MORC2", "MORF4L1", "MORF4L2", "MOSPD2", "MOV10", "MPC2", "MPG", "MPHOSPH10", "MPHOSPH6", "MPHOSPH8", "MPI", "MPP1", "MPP2", "MPP6", "MPP7", "MPRIP", "MPST", "MPV17", "MPV17L2", "MRC2", "MRE11", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL14", "MRPL15", "MRPL17", "MRPL19", "MRPL2", "MRPL20", "MRPL21", "MRPL22", "MRPL24", "MRPL28", "MRPL3", "MRPL37", "MRPL38", "MRPL39", "MRPL40", "MRPL41", "MRPL43", "MRPL44", "MRPL46", "MRPL47", "MRPL48", "MRPL49", "MRPL50", "MRPL53", "MRPL58", "MRPL9", "MRPS11", "MRPS16", "MRPS18A", "MRPS22", "MRPS23", "MRPS25", "MRPS27", "MRPS28", "MRPS30", "MRPS31", "MRPS33", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRPS9", "MRRF", "MRTO4", "MSH2", "MSH3", "MSH6", "MSI1", "MSI2", "MSMO1", "MSN", "MSTO1", "MTA1", "MTA2", "MTAP", "MTBP", "MTCH1", "MTCH2", "MTDH", "MTHFD1L", "MTHFD2", "MTHFS", "MTMR14", "MTMR2", "MTMR6", "MTO1", "MTOR", "MTPAP", "MTPN", "MTR", "MTX1", "MTX2", "MTX3", "MUL1", "MUT", "MVD", "MYBBP1A", "MYCBP", "MYCBP2", "MYDGF", "MYG1", "MYH10", "MYH14", "MYH9", "MYL6", "MYO18A", "MYO1B", "MYO1C", "MYO1D", "MYO6", "NAA10", "NAA15", "NAA25", "NAA35", "NAA40", "NAA50", "NAE1", "NAF1", "NAGLU", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NAPG", "NARS", "NASP", "NAT10", "NAXE", "NBAS", "NBN", "NCAPD2", "NCAPD3", "NCAPG", "NCAPG2", "NCAPH", "NCBP1", "NCBP3", "NCDN", "NCEH1", "NCKAP1", "NCKIPSD", "NCL", "NCLN", "NCOA5", "NCOR1", "NCSTN", "ND1", "NDC1", "NDC80", "NDRG3", "NDUFA10", "NDUFA11", "NDUFA13", "NDUFA4", "NDUFA5", "NDUFA7", "NDUFA8", "NDUFA9", "NDUFAF2", "NDUFAF3", "NDUFAF4", "NDUFAF7", "NDUFB10", "NDUFB3", "NDUFB4", "NDUFB5", "NDUFB6", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS6", "NDUFS7", "NDUFS8", "NDUFV1", "NDUFV2", "NECAP2", "NEDD1", "NEDD4L", "NEFL", "NEFM", "NEK9", "NELFA", "NELFCD", "NELFE", "NEMF", "NENF", "NES", "NF1", "NFATC2IP", "NFKBIL1", "NFS1", "NFU1", "NFXL1", "NHLRC2", "NHP2", "NIFK", "NIP7", "NIPBL", "NIPSNAP1", "NIPSNAP2", "NISCH", "NIT2", "NKRF", "NKTR", "NLE1", "NLN", "NLRX1", "NME1", "NME2", "NMT1", "NNT", "NOA1", "NOB1", "NOC2L", "NOC3L", "NOC4L", "NOL10", "NOL11", "NOL6", "NOL7", "NOL8", "NOL9", "NOLC1", "NOM1", "NONO", "NOP14", "NOP16", "NOP2", "NOP53", "NOP56", "NOP58", "NOP9", "NOSIP", "NOTCH2", "NPC1", "NPC2", "NPEPPS", "NPLOC4", "NPM1", "NRBP1", "NRDC", "NRDE2", "NRP1", "NSA2", "NSD1", "NSD2", "NSD3", "NSDHL", "NSF", "NSMCE2", "NSUN2", "NT5C2", "NT5C3A", "NT5C3B", "NT5DC1", "NT5DC2", "NTHL1", "NTMT1", "NTPCR", "NUB1", "NUBP2", "NUBPL", "NUCB1", "NUCB2", "NUCKS1", "NUDC", "NUDCD1", "NUDCD2", "NUDCD3", "NUDT1", "NUDT16L1", "NUDT21", "NUDT5", "NUF2", "NUFIP2", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP160", "NUP188", "NUP205", "NUP210", "NUP214", "NUP35", "NUP37", "NUP43", "NUP50", "NUP54", "NUP58", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NUPL2", "NUSAP1", "NUTF2", "NVL", "NXF1", "NXN", "OARD1", "OAT", "OCIAD1", "OCLN", "OCRL", "ODR4", "OGDH", "OGFOD3", "OGT", "OLA1", "OPA1", "OPA3", "ORC2", "ORC3", "ORC5", "OSBP", "OSBPL11", "OSBPL1A", "OSBPL6", "OSBPL8", "OSBPL9", "OSGEP", "OSTF1", "OTUB1", "OXA1L", "OXSR1", "P3H1", "P3H4", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PAF1", "PAFAH1B1", "PAFAH1B2", "PAFAH1B3", "PAICS", "PAK1IP1", "PAK2", "PALD1", "PALLD", "PANK4", "PAPOLA", "PAPSS1", "PARD3", "PARG", "PARK7", "PARN", "PARP1", "PARP2", "PATL1", "PBDC1", "PBK", "PBRM1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCM1", "PCMT1", "PCNA", "PCYOX1", "PDAP1", "PDCD11", "PDCD5", "PDCD6", "PDCD6IP", "PDCL3", "PDE12", "PDHA1", "PDHB", "PDHX", "PDIA3", "PDIA4", "PDIA6", "PDK1", "PDK3", "PDLIM1", "PDLIM5", "PDP1", "PDS5A", "PDS5B", "PDSS2", "PDXDC1", "PDZD8", "PEBP1", "PECR", "PEF1", "PELO", "PELP1", "PEPD", "PES1", "PEX11B", "PEX14", "PEX19", "PEX3", "PFAS", "PFDN2", "PFDN4", "PFDN5", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGM3", "PGP", "PGRMC1", "PGRMC2", "PHB", "PHB2", "PHF10", "PHF2", "PHF3", "PHF5A", "PHF6", "PHGDH", "PHIP", "PHKA1", "PHKB", "PI4K2A", "PI4KA", "PI4KB", "PICALM", "PIGG", "PIGK", "PIGS", "PIGT", "PIGU", "PIH1D1", "PIK3C2A", "PIK3R2", "PIK3R4", "PIN1", "PIN4", "PINX1", "PIP4K2C", "PIR", "PISD", "PITHD1", "PITPNA", "PITPNB", "PITRM1", "PKM", "PKMYT1", "PKN1", "PKN2", "PLA2G15", "PLAA", "PLBD2", "PLCG1", "PLD3", "PLD6", "PLEC", "PLEKHA5", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLRG1", "PLS3", "PLXNB2", "PM20D2", "PMPCA", "PMPCB", "PMVK", "PNKP", "PNN", "PNO1", "PNP", "PNPLA6", "PNPLA8", "PNPT1", "POFUT1", "POGZ", "POLA1", "POLA2", "POLD1", "POLD2", "POLDIP2", "POLDIP3", "POLE", "POLE2", "POLG", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2B", "POLR2C", "POLR2D", "POLR2E", "POLR2G", "POLR2L", "POLR3A", "POLR3B", "POLR3C", "POLRMT", "PON2", "POP1", "POP4", "POR", "PPA1", "PPA2", "PPAN", "PPAT", "PPCDC", "PPFIA1", "PPHLN1", "PPIB", "PPIC", "PPID", "PPIE", "PPIF", "PPIG", "PPIH", "PPIL4", "PPM1G", "PPME1", "PPOX", "PPP1CA", "PPP1CB", "PPP1R10", "PPP1R7", "PPP1R8", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP2R5E", "PPP3CA", "PPP4R1", "PPP4R3A", "PPP5C", "PPP6C", "PPP6R3", "PPT1", "PPWD1", "PQBP1", "PRAF2", "PRC1", "PRCC", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PREP", "PREPL", "PRIM1", "PRIM2", "PRKAA1", "PRKAA2", "PRKACA", "PRKAG1", "PRKAR1A", "PRKAR2A", "PRKCB", "PRKCSH", "PRKDC", "PRMT1", "PRMT3", "PRMT5", "PRMT9", "PRPF19", "PRPF3", "PRPF31", "PRPF38B", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPS2", "PRPSAP1", "PRPSAP2", "PRRC1", "PRRC2A", "PRRC2C", "PSAP", "PSAT1", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD6", "PSMD7", "PSMD8", "PSME1", "PSME2", "PSME3", "PSME4", "PSMG1", "PSMG2", "PSMG3", "PSPC1", "PTBP1", "PTBP2", "PTCD1", "PTCD3", "PTDSS1", "PTDSS2", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK2", "PTK7", "PTPA", "PTPN1", "PTPN11", "PTPN23", "PTPRF", "PTRH2", "PUF60", "PUM3", "PURA", "PUS1", "PUS7", "PUS7L", "PWP1", "PWP2", "PXMP2", "PXN", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QDPR", "QKI", "QRSL1", "QSOX2", "QTRT2", "R3HCC1", "RAB10", "RAB12", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB1B", "RAB23", "RAB24", "RAB2A", "RAB35", "RAB3B", "RAB3GAP1", "RAB3GAP2", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RAB8A", "RAB9A", "RABEPK", "RABGAP1", "RABGGTA", "RABL3", "RABL6", "RAC1", "RACGAP1", "RACK1", "RAD18", "RAD21", "RAD23A", "RAD23B", "RAD50", "RAD54L2", "RAE1", "RAI14", "RALA", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP6", "RANBP9", "RANGAP1", "RAP1GDS1", "RAPGEF2", "RARS", "RARS2", "RAVER1", "RBBP4", "RBBP5", "RBBP6", "RBBP7", "RBM10", "RBM12", "RBM12B", "RBM14", "RBM17", "RBM19", "RBM22", "RBM25", "RBM26", "RBM27", "RBM28", "RBM3", "RBM34", "RBM39", "RBM4", "RBM45", "RBM47", "RBM5", "RBM6", "RBM8A", "RBMX", "RBMXL1", "RBPJ", "RCC1", "RCC2", "RCL1", "RCN1", "RCN2", "RDH11", "RDH13", "RDH14", "RDX", "RECQL", "REEP4", "REEP5", "RER1", "RETSAT", "REXO2", "REXO4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RFT1", "RHBDD2", "RHEB", "RHOG", "RHOT1", "RHOT2", "RIDA", "RIF1", "RINT1", "RIPK1", "RMDN1", "RMDN3", "RNASEH2A", "RNASET2", "RNF2", "RNF20", "RNF40", "RNMT", "RNPEP", "RNPS1", "ROBO1", "ROCK1", "ROCK2", "RP2", "RPA1", "RPA2", "RPAP1", "RPAP3", "RPF1", "RPF2", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPN1", "RPN2", "RPP30", "RPP38", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS26", "RPS28", "RPS29", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RPTOR", "RPUSD3", "RRAS2", "RRBP1", "RREB1", "RRM1", "RRM2", "RRP1", "RRP12", "RRP15", "RRP1B", "RRP36", "RRP8", "RRP9", "RRS1", "RSBN1", "RSF1", "RSL1D1", "RSL24D1", "RSPRY1", "RSU1", "RTCA", "RTCB", "RTFDC1", "RTN1", "RTN2", "RTN3", "RTN4", "RTN4IP1", "RTRAF", "RUFY1", "RUVBL1", "RUVBL2", "S100A11", "S100A13", "SAAL1", "SACM1L", "SAE1", "SAFB", "SAFB2", "SALL2", "SAMD4B", "SAMHD1", "SAMM50", "SAP130", "SAP18", "SAP30BP", "SAR1A", "SAR1B", "SARM1", "SARNP", "SARS", "SARS2", "SART1", "SART3", "SBDS", "SBNO1", "SCAF1", "SCAF11", "SCAF4", "SCAMP1", "SCAMP2", "SCAMP3", "SCAMP4", "SCARB1", "SCARB2", "SCCPDH", "SCD", "SCFD1", "SCFD2", "SCML2", "SCO1", "SCO2", "SCP2", "SCPEP1", "SCRIB", "SCRN1", "SCYL1", "SDAD1", "SDF4", "SDHA", "SDHB", "SDHC", "SDR39U1", "SEC11A", "SEC16A", "SEC22B", "SEC23A", "SEC23B", "SEC23IP", "SEC24A", "SEC24B", "SEC24C", "SEC31A", "SEC61A1", "SEC61B", "SEC62", "SEC63", "SEH1L", "SEL1L", "SENP3", "SEPT11", "SEPT2", "SEPT7", "SEPT9", "SERBP1", "SERPINB6", "SERPINH1", "SET", "SETD1A", "SETD2", "SETD3", "SETDB1", "SEZ6L2", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFSWAP", "SFXN1", "SFXN2", "SFXN4", "SGF29", "SGPL1", "SGTA", "SH3GL1", "SH3GLB1", "SHCBP1", "SHMT1", "SHMT2", "SHTN1", "SIGMAR1", "SIN3A", "SKA1", "SKA3", "SKIV2L", "SKIV2L2", "SKP1", "SKP2", "SLC12A2", "SLC12A9", "SLC16A1", "SLC19A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A16", "SLC25A17", "SLC25A19", "SLC25A20", "SLC25A21", "SLC25A24", "SLC25A25", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A33", "SLC25A4", "SLC25A44", "SLC25A5", "SLC25A6", "SLC27A4", "SLC33A1", "SLC35B2", "SLC35F2", "SLC39A14", "SLC3A2", "SLC4A1AP", "SLC4A2", "SLC5A6", "SLC7A1", "SLC9A3R1", "SLFN11", "SLIRP", "SLIT2", "SLK", "SLMAP", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC5", "SMC6", "SMCHD1", "SMG1", "SMG5", "SMN1*", "SMNDC1", "SMPD4", "SMS", "SMU1", "SND1", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPC", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNU13", "SNW1", "SNX1", "SNX17", "SNX19", "SNX2", "SNX27", "SNX3", "SNX5", "SNX6", "SNX9", "SOAT1", "SOD2", "SON", "SORD", "SORT1", "SPAG5", "SPAG9", "SPART", "SPATA5", "SPATA5L1", "SPATS2L", "SPC25", "SPCS2", "SPCS3", "SPDL1", "SPECC1L", "SPEN", "SPNS1", "SPOUT1", "SPPL2A", "SPR", "SPRYD4", "SPTAN1", "SPTBN1", "SPTLC1", "SPTLC2", "SQLE", "SRC", "SRCAP", "SREK1", "SRI", "SRM", "SRP14", "SRP54", "SRP68", "SRP72", "SRP9", "SRPK1", "SRPK2", "SRPRA", "SRPRB", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF3", "SRSF4", "SRSF5", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSR1", "SSR4", "SSRP1", "STAG1", "STAG2", "STAM", "STAM2", "STAT1", "STAT3", "STAU1", "STAU2", "STIP1", "STK26", "STK3", "STK4", "STMN1", "STOM", "STOML2", "STRAP", "STRBP", "STRIP1", "STRN", "STT3A", "STT3B", "STUB1", "STX10", "STX12", "STX16", "STX18", "STX4", "STX7", "STX8", "STXBP2", "STXBP3", "STXBP4", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGP2", "SUGT1", "SUN1", "SUN2", "SUPT16H", "SUPT3H", "SUPT5H", "SUPT6H", "SUPV3L1", "SURF6", "SUZ12", "SV2A", "SYAP1", "SYMPK", "SYNCRIP", "SYNE1", "SYNE2", "SYNGR2", "SYNJ2BP", "SYS1", "TAB1", "TACC3", "TAF15", "TAF6", "TAGLN2", "TALDO1", "TAMM41", "TAP1", "TAP2", "TARBP1", "TARDBP", "TARS", "TARS2", "TARSL2", "TBC1D13", "TBC1D15", "TBC1D4", "TBC1D9B", "TBCA", "TBCB", "TBCD", "TBCE", "TBL1XR1", "TBL2", "TBL3", "TBRG4", "TCAF1", "TCEA1", "TCERG1", "TCOF1", "TCP1", "TCP11L1", "TDRKH", "TECR", "TEFM", "TELO2", "TERF2IP", "TES", "TEX10", "TEX264", "TFAM", "TFB1M", "TFCP2", "TFG", "TFIP11", "TFRC", "TGFBRAP1", "TGOLN2", "THADA", "THAP11", "THEM6", "THOC1", "THOC2", "THOC3", "THOC5", "THOC6", "THOP1", "THRAP3", "THUMPD1", "THYN1", "TIA1", "TIAL1", "TIGAR", "TIMM10B", "TIMM17B", "TIMM23", "TIMM44", "TIMM50", "TIMM8B", "TJP1", "TJP2", "TK1", "TKT", "TLCD1", "TLE3", "TLK2", "TLN1", "TM9SF2", "TM9SF3", "TM9SF4", "TMA16", "TMCO1", "TMED10", "TMED2", "TMED7", "TMED9", "TMEM109", "TMEM11", "TMEM115", "TMEM126A", "TMEM14C", "TMEM161A", "TMEM167A", "TMEM19", "TMEM192", "TMEM199", "TMEM201", "TMEM205", "TMEM214", "TMEM230", "TMEM259", "TMEM33", "TMEM43", "TMEM65", "TMEM87A", "TMEM97", "TMLHE", "TMOD3", "TMPPE", "TMTC3", "TMX1", "TMX2", "TMX3", "TNKS1BP1", "TNPO1", "TNPO2", "TNPO3", "TOE1", "TOMM20", "TOMM22", "TOMM34", "TOMM40", "TOMM5", "TOMM70", "TOP1", "TOP2A", "TOP2B", "TOPBP1", "TOR1A", "TOR1AIP1", "TOR1B", "TOX4", "TP53", "TP53BP1", "TP53BP2", "TPBG", "TPD52", "TPD52L2", "TPI1", "TPM3", "TPM4", "TPP1", "TPP2", "TPR", "TPT1", "TPX2", "TRA2A", "TRA2B", "TRABD", "TRAF2", "TRAP1", "TRAPPC11", "TRAPPC4", "TRAPPC5", "TRIM13", "TRIM21", "TRIM25", "TRIM26", "TRIM27", "TRIM28", "TRIM33", "TRIM4", "TRIO", "TRIP12", "TRIP13", "TRIP4", "TRIR", "TRMT1", "TRMT10C", "TRMT11", "TRMT1L", "TRMT2A", "TRMT6", "TRMU", "TROVE2", "TRRAP", "TRUB1", "TSFM", "TSG101", "TSN", "TSNAX", "TSPAN3", "TSPAN6", "TSR1", "TST", "TTC1", "TTC19", "TTC26", "TTC27", "TTC28", "TTC37", "TTC38", "TTC4", "TTF2", "TTK", "TTLL12", "TTYH3", "TUBB", "TUBB2A", "TUBB2B", "TUBB3", "TUBB4A", "TUBB6", "TUBGCP2", "TUBGCP3", "TUFM", "TWF2", "TWNK", "TXLNA", "TXLNG", "TXNDC12", "TXNDC15", "TXNDC17", "TXNDC5", "TXNDC9", "TXNL1", "TXNRD1", "TYMS", "U2AF1", "U2AF2", "U2SURP", "UAP1", "UBA1", "UBA2", "UBA3", "UBA6", "UBAC1", "UBAP2L", "UBE2J1", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2O", "UBE2S", "UBE3A", "UBE3C", "UBE4A", "UBFD1", "UBLCP1", "UBQLN4", "UBR2", "UBR4", "UBR5", "UBTF", "UBXN1", "UBXN4", "UBXN7", "UCHL5", "UCK2", "UFC1", "UFD1", "UFL1", "UFM1", "UGCG", "UGDH", "UGGT1", "UGP2", "UGT8", "UHRF1", "UMPS", "UNC45A", "UPF1", "UPF2", "UPF3B", "UQCC2", "UQCR10", "UQCRB", "UQCRC1", "UQCRC2", "UQCRFS1", "UQCRQ", "URB1", "URGCP", "UROD", "USMG5", "USO1", "USP10", "USP11", "USP14", "USP19", "USP24", "USP28", "USP36", "USP39", "USP47", "USP48", "USP5", "USP7", "USP9X", "UTP11", "UTP14A", "UTP15", "UTP18", "UTP20", "UTP3", "UTP4", "UTP6", "UTRN", "VAMP7", "VANGL1", "VANGL2", "VAPA", "VAPB", "VARS1", "VARS2", "VAT1", "VBP1", "VCL", "VCP", "VDAC1", "VDAC2", "VDAC3", "VIM", "VIPAS39", "VIRMA", "VPS13A", "VPS13C", "VPS16", "VPS18", "VPS26A", "VPS29", "VPS33A", "VPS33B", "VPS35", "VPS37B", "VPS45", "VPS4A", "VPS4B", "VPS50", "VPS51", "VPS52", "VPS53", "VRK1", "VRK3", "VTA1", "WAPL", "WARS", "WASHC4", "WASHC5", "WBP11", "WBP2", "WDHD1", "WDR1", "WDR11", "WDR12", "WDR18", "WDR26", "WDR3", "WDR33", "WDR36", "WDR4", "WDR41", "WDR43", "WDR46", "WDR5", "WDR6", "WDR61", "WDR7", "WDR73", "WDR74", "WDR75", "WDR77", "WDR82", "WDR91", "WFS1", "WIPI2", "WIZ", "WLS", "WRAP73", "WRNIP1", "WTAP", "XAB2", "XPNPEP1", "XPNPEP3", "XPO1", "XPO4", "XPO5", "XPO7", "XPOT", "XRCC1", "XRCC5", "XRCC6", "XRN2", "XXYLT1", "YARS", "YARS2", "YEATS2", "YEATS4", "YIF1A", "YKT6", "YLPM1", "YME1L1", "YOD1", "YTHDC1", "YTHDC2", "YTHDF2", "YTHDF3", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2", "ZC3H11A", "ZC3H14", "ZC3H15", "ZC3H18", "ZC3H4", "ZC3H7A", "ZC3HAV1", "ZCCHC11", "ZCCHC3", "ZCCHC8", "ZFR", "ZFYVE16", "ZMPSTE24", "ZMYM2", "ZMYM4", "ZNF281", "ZNF318", "ZNF326", "ZNF512B", "ZNF622", "ZNF638", "ZPR1", "ZRANB2", "ZW10", "ZWILCH", "ZYX", "ZZEF1"], "leading_proteins": ["ABCB10", "ABCB6", "ABCB8", "ABCD3", "ABHD12", "ACBD5", "ACOX3", "ACP2", "ACP6", "ACSL6", "ADD3", "ADPGK", "AGK", "AGL", "AGPAT5", "AGPS", "AHSA1", "AIFM1", "AK3", "AKAP10", "AKT2", "ALDH16A1", "ALDH3A2", "ALG1", "ALG11", "ANKLE2", "ANO10", "ANO6", "AP3B1", "APOO", "APP", "ARL6IP1", "ARL6IP5", "ARMC10", "ASAH1", "ASNA1", "ATAD3A", "ATG9A", "ATL2", "ATP13A1", "ATP1A1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP2B4", "ATP2C1", "ATP5B", "ATP5F1", "ATP5I", "ATP5L", "ATP6AP1", "ATP6AP2", "ATP6V0A1", "ATP6V0A2", "ATP7A", "ATP7B", "ATXN10", "B3GALT6", "BCAP31", "BICD2", "BNIP1", "BRAP", "BRCA1", "BSG", "BUB1B", "C19orf70", "CANX", "CCDC47", "CCDC6", "CCDC93", "CD47", "CDKAL1", "CDS2", "CERS2", "CERS5", "CHKA", "CHST14", "CIB1", "CIT", "CKAP4", "CLCC1", "CLCN3", "CLCN7", "CLN5", "CLPTM1", "CLPTM1L", "CNNM3", "CNNM4", "COA3", "COLEC12", "COMT", "COQ9", "COX15", "COX18", "COX2", "COX4I1", "COX5A", "COX7A2L", "CPT1A", "CPT2", "CRYZ", "CSGALNACT2", "CTSA", "CTSC", "CXADR", "CYB5B", "CYC1", "CYP20A1", "CYP51A1", "DAGLB", "DCAKD", "DDRGK1", "DERL1", "DERL2", "DHCR24", "DHCR7", "DHFR", "DHPS", "DLD", "DLG1", "DNA2", "DNAJC1", "DNAJC11", "DNAJC16", "DOLPP1", "EBP", "ECE1", "EFCAB14", "EI24", "EIF2B5", "EIF3E", "EIF3F", "EMC2", "EMC7", "EMD", "ENDOD1", "EPDR1", "EPHA7", "EPHX1", "ERAP1", "ERAP2", "ERGIC1", "ERGIC3", "ERLIN2", "ERMP1", "ETFDH", "EXOSC3", "FAF2", "FAM162A", "FAM177A1", "FANCD2", "FDFT1", "FDPS", "FECH", "FGFR1OP", "FIS1", "FKBP10", "FKBP14", "FKBP7", 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--- /dev/null +++ b/protein_atlas_subcellular_location_all/df_merge.tsv @@ -0,0 +1,4 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Lipid droplets 4 10 2.1774214923236968 0.029449133540536 3.0072815533980584 9.62621359223301 0.341030817631545 0.5500740955075814 1.9327141206562328 1.0125869172856077 0.8582489651663355 0.3093604356540435 0.2572343334310336 1.0 1.0 0.4439075633632242 0.32624452618512 +Endoplasmic reticulum 80 200 2.018136224530587 0.0435770759200193 55.37621359223301 196.57766990291265 1.2201083743235763 0.4903523338807414 18.868778270733547 13.264167600850914 1.8573715045605257 0.4308007257692164 1.8766989454295877e-18 0.0002296910879912 1.0611285982048457e-06 3.1598394320288786e-15 7.886146263946916e-24 +Peroxisomes 8 16 2.007062905079824 0.0447429653914477 5.322815533980583 14.701456310679612 0.4359129333192138 0.4564689114892047 2.679509416580786 1.5010345350043446 1.0794334084892987 0.3191667601086948 0.0094903075706385 1.0 1.0 0.4015375820029667 0.017002584405276 diff --git a/protein_atlas_subcellular_location_all/metrics.json b/protein_atlas_subcellular_location_all/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..e2a6247aeab8291b19803aef59d7b4eb473c5b25 --- /dev/null +++ b/protein_atlas_subcellular_location_all/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3221, + "annotations_size": 33, + "title": "Average number of proteins per term", + "value": 150.5151515151515 +} \ No newline at end of file diff --git a/protein_atlas_subcellular_location_all/paths.json b/protein_atlas_subcellular_location_all/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..465513a3ff5d17afa1f84a705510af3749072490 --- /dev/null +++ b/protein_atlas_subcellular_location_all/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/protein_atlas_subcellular_location_all/fragment/C201/C201_val_log2fc"} \ No newline at end of file diff --git a/protein_atlas_subcellular_location_all/result.tsv b/protein_atlas_subcellular_location_all/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..ca90694592ca29182b73f82889dd052506d33521 --- /dev/null +++ b/protein_atlas_subcellular_location_all/result.tsv @@ -0,0 +1,10 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Lipid droplets 0.7053845914731062 2.1774214923236968 0.029449133540536 0.627090064685358 0.1845647322397219 10 Q969V3,Q01105,Q96CS3,Q8NF37 4 +Endoplasmic reticulum 0.5325363841910256 2.018136224530587 0.0435770759200193 0.7701474954149681 0.1845647322397219 200 Q8N6G5,Q96PC5,Q9NR31,Q86XL3,Q9NQC3,Q9P2W9,Q15800,Q5T9L3,Q9UM00,O43169,O95197,P43307,P13674,Q6PIU2,P51648,Q16850,O95470,P04843,Q96CS3,P62820,Q4ZIN3,Q99442,O96005,Q8TCT9,P51571,Q14257,Q70UQ0,Q96A33,Q8IV08,O00264,P21964,Q9BT22,P35790,Q96G23,Q9H6H4,Q9GZP9,O43852,Q92791,Q9P035,Q8NHH9,Q96A57,Q15043,Q15041,Q15125,O60831,P37268,P51572,Q9H3N1,Q96KA5,Q96S66,Q9Y680,Q9H3G5,Q8NF37,Q5HYI8,O15269,Q9NZ01,O95674,P50402,Q12981,P0CG08,Q6UW68,P27824,Q5BJF2,O14681,Q99735,Q00765,Q03519,Q96KC8,Q9BUN8,Q86UE4,O15460,P48651,Q9UBM7,Q6NUQ4,Q03518,Q96HY6,Q16799,Q96AG4,O94905,O75915 80 +Peroxisomes 0.5915627460232883 2.007062905079824 0.0447429653914477 0.7792157594432817 0.1845647322397219 16 P28288,O43808,O00116,P56589,O15254,P40855,O75381,Q5T8D3 8 +Golgi apparatus 0.4837117475039549 1.6517932130151027 0.098576712734524 0.9674426144917389 0.3218994322341828 177 Q86Y82,Q6P179,Q8N4Q0,Q8NBN3,Q9NX62,Q99640,O15127,P80303,Q8TDW0,Q6ZRP7,O60637,O95070,P16278,P50897,P98194,P09601,Q8N4A0,P24390,P04439,Q8IZA0,Q5VW38,Q8TBA6,Q5KU26,P05067,Q14789,Q9H2V7,O43493,Q9NUJ3,P35670,Q04656,Q6NUQ4,Q9BSL1,P67812,Q9BRK5,O43760,Q96J42,O60499,Q8TD16,Q02818,Q15043,P55327,Q08378,Q9HD45,Q9NTJ5,O14681,O00231,Q9HB40,Q9UG56,Q9NWM8,Q16706,Q93050,P49755,Q8NCH0,Q9NP58,O00461,Q92896,O75071,A1L0T0,O75955,O15258,Q6NTF9,O00203 62 +Lysosomes 0.5497898086719295 1.6104492750181845 0.1072998107447276 0.9763796849537892 0.3218994322341828 14 O15400,Q8IY95,O60749,Q8WTV0 4 +Nuclear membrane 0.3226729542216035 0.7821788726319538 0.4341094590411332 0.9999999930789762 0.6228527021024954 60 Q7Z569,P67812,Q9UH99,P20700,P50402,Q14728,Q6UW68,O95168,O14656,Q03252,Q96G23,Q9BTX1,Q14739,Q5SNT2,O94919 15 +Endosomes 0.3852702409022286 0.4578960847132823 0.6470270999228469 0.9999999999999988 0.854075771898158 12 Q8IY95,O60749 2 +Intermediate filaments 0.3030922286431886 0.2007962695951825 0.8408578799574546 1.0 1.0 36 Q3SXM5,P07196,Q86YN1,Q99442,Q99471,Q16352,P08670,P07197 8 +Centriolar satellite 0.2943705216607685 0.1311525603185065 0.8956546230862517 1.0 1.0 27 P41208,Q00013,Q9Y6A5,Q03518,Q15154,P33176,Q15691,P11413,O43169,Q53EZ4,Q01968 11 diff --git a/protein_atlas_subcellular_location_all/selections.json b/protein_atlas_subcellular_location_all/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..789da02995e48bf03c1b1616f0648102aa4b2e41 --- /dev/null +++ b/protein_atlas_subcellular_location_all/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["Actin filaments", "Cell Junctions", "Centriolar satellite", "Centrosome", "Cytokinetic bridge", "Cytoplasmic bodies", "Cytosol", "Endoplasmic reticulum", "Endosomes", "Focal adhesion sites", "Golgi apparatus", "Intermediate filaments", "Kinetochore", "Lipid droplets", "Lysosomes", "Microtubule ends", "Microtubules", "Midbody", "Midbody ring", "Mitochondria", "Mitotic chromosome", "Mitotic spindle", "Nuclear bodies", "Nuclear membrane", "Nuclear speckles", "Nucleoli", "Nucleoli fibrillar center", "Nucleoli rim", "Nucleoplasm", "Peroxisomes", "Plasma membrane", "Rods & Rings", "Vesicles"], "available_proteins": ["AAAS", "AAR2", "AARS", "AARS2", "AASS", "AATF", "ABCB1", "ABCB6", "ABCB7", "ABCB8", "ABCC4", "ABCD3", "ABCE1", "ABCF1", "ABCF2", "ABCF3", "ABHD10", "ABHD14B", "ABHD6", "ABRACL", "ABRAXAS2", "ACAA1", "ACAA2", "ACACA", "ACAD9", "ACADM", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACBD5", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT8", "ACOT9", "ACOX1", "ACOX3", "ACP1", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN4", "ACTR1A", "ACTR1B", "ACTR2", "ACTR8", "ADA", "ADAR", "ADD1", "ADD3", "ADI1", "ADK", "ADNP", "ADPGK", "ADRM1", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGK", "AGL", "AGPAT1", "AGPAT5", "AGPS", "AHCTF1", "AHCY", "AHCYL1", "AHNAK", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AK3", "AK4", "AK6", "AKAP1", "AKAP10", "AKAP8", "AKAP8L", "AKAP9", "AKR1A1", "AKR1B1", "AKR7A2", "AKT2", "ALDH18A1", "ALDH1B1", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALG1", "ALG5", "ALKBH5", "AMOT", "ANAPC1", "ANAPC16", "ANAPC2", "ANAPC4", "ANAPC5", "ANAPC7", "ANGEL1", "ANK3", "ANKFY1", "ANKLE2", "ANKRD17", "ANLN", "ANO10", "ANO6", "ANP32A", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA4", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP1S1", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP3B1", "AP3D1", "APEH", "APEX1", "API5", "APMAP", "APOO", "APOOL", "APP", "APPL1", "APRT", "AQR", "ARCN1", "ARF6", "ARFGAP1", "ARFIP1", "ARFIP2", "ARG2", "ARGLU1", "ARHGAP17", "ARHGDIA", "ARID1A", "ARID2", "ARID3B", "ARIH2", "ARL1", "ARL2", "ARL3", "ARL6IP1", "ARL6IP5", "ARMC1", "ARMC10", "ARMC6", "ARMCX3", "ARMT1", "ARPC1A", "ARPC2", "ARPC3", "ARVCF", "ASCC2", "ASCC3", "ASH2L", "ASNA1", "ASNS", "ASPH", "ASPSCR1", "ATAD1", "ATAD2", "ATAD3A", "ATAD3B", "ATAD5", "ATG3", "ATG9A", "ATIC", "ATL2", "ATP13A1", "ATP1B3", "ATP2B1", "ATP2B4", "ATP2C1", "ATP5A1", "ATP5B", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6V0A1", "ATP6V0A2", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1D", "ATP6V1E1", "ATP6V1H", "ATP7A", "ATP7B", "ATPAF1", "ATPIF1", "ATRIP", "ATXN10", "ATXN2L", "AUP1", "AURKA", "BABAM1", "BABAM2", "BAG2", "BAG3", "BAG5", "BAG6", "BAIAP2", "BANF1", "BAP18", "BARD1", "BASP1", "BAZ1B", "BAZ2A", "BCAP31", "BCAS2", "BCAS3", "BCCIP", "BCKDK", "BCL2L12", "BCLAF1", "BCR", "BICD2", "BIRC6", "BLM", "BLMH", "BLVRA", "BMS1", "BNIP1", "BOLA2*", "BOP1", "BPNT1", "BPTF", "BRAP", "BRCA1", "BRD1", "BRD2", "BRD4", "BRIX1", "BRMS1L", "BSG", "BTAF1", "BTF3", "BUB1B", "BUB3", "BUD23", "BUD31", "BYSL", "BZW1", "BZW2", "C12orf73", "C17orf75", "C19orf25", "C19orf70", "C1QBP", "C1orf123", "C1orf35", "C2CD5", "C2orf49", "C4orf46", "C5orf51", "C8orf33", "C9orf64", "CAB39", "CACYBP", "CAD", "CALD1", "CALR", "CALU", "CAMK2G", "CAMSAP3", "CAND1", "CAND2", "CANT1", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPNS1", "CAPRIN1", "CAPZB", "CARS", "CASK", "CAST", "CBR1", "CBX1", "CBX2", "CBX3", "CBX5", "CBX8", "CC2D1A", "CCAR1", "CCAR2", "CCDC138", "CCDC22", "CCDC47", "CCDC59", "CCDC6", "CCDC86", "CCDC93", "CCDC97", "CCNB1", "CCT2", "CCT3", "CCT4", "CCT6A", "CCT7", "CCT8", "CD2AP", "CD2BP2", "CD3EAP", "CD47", "CDC123", "CDC27", "CDC37", "CDC42", "CDC5L", "CDC73", "CDCA2", "CDCA5", "CDCA7L", "CDCA8", "CDH2", "CDIPT", "CDK1", "CDK12", "CDK2", "CDK4", "CDK5", "CDK5RAP1", "CDK5RAP3", "CDK6", "CDK9", "CDKN2AIP", "CDS2", "CEBPZ", "CELF1", "CELF2", "CENPB", "CENPI", "CENPP", "CENPV", "CEP170", "CEP55", "CEP72", "CERS2", "CERS5", "CETN2", "CFAP20", "CFL1", "CFL2", "CHAC2", "CHAF1A", "CHAF1B", "CHAMP1", "CHCHD3", "CHD1", "CHD1L", "CHD4", "CHD8", "CHID1", "CHKA", "CHMP2B", "CHMP5", "CHMP7", "CHORDC1", "CHRAC1", "CHST14", "CHTF18", "CHTOP", "CIAPIN1", "CIB1", "CIP2A", "CIRBP", "CISD2", "CIT", "CIZ1", "CKAP2", "CKAP5", "CKB", "CLASP2", "CLCC1", "CLCN3", "CLGN", "CLIC1", "CLINT1", "CLNS1A", "CLPP", "CLPTM1", "CLPTM1L", "CLPX", "CLSPN", "CLTA", "CLTB", "CLTC", "CLUH", "CMAS", "CMPK1", "CMTR1", "CNDP2", "CNN2", "CNN3", "CNNM3", "CNNM4", "CNOT1", "CNOT9", "CNP", "COA3", "COA7", "COG2", "COG3", "COG5", "COG6", "COG7", "COIL", "COL4A3BP", "COLEC12", "COLGALT1", "COMMD8", "COMT", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPS2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS8", "COQ8A", "COQ9", "CORO1B", "COTL1", "COX15", "COX4I1", "COX5B", "COX6C", "COX7A2L", "CPD", "CPNE1", "CPNE2", "CPNE3", "CPOX", "CPSF1", "CPSF2", "CPSF6", "CPSF7", "CPT1A", "CPT2", "CPVL", "CRK", "CRKL", "CRTAP", "CRYZ", "CS", "CSDE1", "CSE1L", "CSGALNACT2", "CSK", "CSNK1A1", "CSNK2A1", "CSTB", "CSTF1", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTPS2", "CTR9", "CTSA", "CTSC", "CTTN", "CTTNBP2NL", "CTU2", "CUL1", "CUL2", "CUL4A", "CUL4B", "CUL5", "CUTA", "CWC15", "CWC22", "CWF19L1", "CXADR", "CXorf56", "CXorf57", "CYB5B", "CYB5R1", "CYB5R3", "CYC1", "CYFIP2", "CYP20A1", "CYP51A1", "DAGLB", "DAP3", "DARS", "DARS2", "DAZAP1", "DBN1", "DBNL", "DBT", "DCAF1", "DCAF13", "DCAF7", "DCAF8", "DCAKD", "DCP1B", "DCPS", "DCTD", "DCTN1", "DCTN2", "DCTN3", "DCTN4", "DCTPP1", "DCUN1D1", "DCUN1D5", "DCXR", "DDB1", "DDI2", "DDOST", "DDRGK1", "DDT", "DDX1", "DDX10", "DDX17", "DDX18", "DDX20", "DDX21", "DDX23", "DDX24", "DDX28", "DDX39A", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX50", "DDX51", "DDX52", "DDX54", "DDX56", "DDX6", "DEK", "DENND6A", "DENR", "DERL1", "DERL2", "DFFA", "DHCR7", "DHFR", "DHPS", "DHRS1", "DHRS13", "DHRS7", "DHRS7B", "DHTKD1", "DHX15", "DHX16", "DHX29", "DHX30", "DHX36", "DHX37", "DHX38", "DHX40", "DHX57", "DHX8", "DHX9", "DIAPH1", "DIAPH2", "DIAPH3", "DICER1", "DIDO1", "DIMT1", "DIS3", "DKC1", "DLAT", "DLD", "DLG1", "DLGAP5", "DLST", "DMAP1", "DNA2", "DNAAF5", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJC1", "DNAJC11", "DNAJC13", "DNAJC16", "DNAJC2", "DNAJC21", "DNAJC3", "DNAJC7", "DNAJC8", "DNAJC9", "DNM1L", "DNM2", "DNMT1", "DNPH1", "DNTTIP2", "DOHH", "DOLPP1", "DPF2", "DPH2", "DPH5", "DPP3", "DPP9", "DPY30", "DPYSL2", "DPYSL3", "DPYSL5", "DRG1", "DRG2", "DSC3", "DSCR3", "DSG2", "DSP", "DST", "DTX3L", "DTYMK", "DUS2", "DUSP12", "DUSP3", "DUSP9", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNC2H1", "DYNLL1", "DYNLL2", "EARS2", "EBNA1BP2", "EBP", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "ECSIT", "EDC3", "EDC4", "EDF1", "EDRF1", "EEA1", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EFCAB14", "EFL1", "EFTUD2", "EHBP1", "EHD1", "EHD4", "EI24", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2D", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E", "EIF4E2", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAC2", "ELAVL1", "ELL", "ELMO2", "ELMOD2", "ELOA", "ELP1", "ELP2", "ELP3", "ELP4", "EMD", "EMG1", "EML4", "ENAH", "ENDOD1", "ENO1", "ENO2", "ENY2", "EP400", "EPB41", "EPB41L2", "EPB41L3", "EPB41L5", "EPHX2", "EPN1", "EPPK1", "EPRS", "EPS15L1", "ERAL1", "ERAP1", "ERAP2", "ERBIN", "ERC1", "ERCC2", "ERCC3", "ERCC6L", "ERGIC1", "ERH", "ERLIN1", "ERLIN2", "ERP29", "ESD", "ESF1", "ESYT1", "ESYT2", "ETFA", "ETFB", "EWSR1", "EXD2", "EXO1", "EXOC2", "EXOC3", "EXOC6", "EXOC7", "EXOC8", "EXOSC1", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC5", "EXOSC7", "EXOSC8", "EXOSC9", "EYA4", "EZR", "F11R", "FAF1", "FAF2", "FAH", "FAHD1", "FAM114A2", "FAM120A", "FAM129B", "FAM136A", "FAM162A", "FAM177A1", "FAM192A", "FAM208A", "FAM49B", "FAM50A", "FAM98A", "FAM98B", "FANCD2", "FANCI", "FAR1", "FARP1", "FARP2", "FARSA", "FARSB", "FASN", "FBL", "FDFT1", "FDPS", "FDXR", "FEN1", "FERMT2", "FGFR1OP", "FH", "FHL1", "FHOD1", "FIP1L1", "FIS1", "FKBP10", "FKBP14", "FKBP2", "FKBP3", "FKBP4", "FKBP5", "FKBP7", "FKBP8", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FMR1", "FNBP4", "FNDC3A", "FNTA", "FNTB", "FOCAD", "FOXC1", "FOXK1", "FOXRED1", "FRYL", "FSCN1", "FTO", "FTSJ3", "FUBP1", "FUBP3", "FUCA1", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GADD45GIP1", "GAK", "GALK1", "GALM", "GALNS", "GALNT2", "GALNT4", "GALNT7", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GATAD2B", "GATB", "GBF1", "GCAT", "GCDH", "GCFC2", "GCLC", "GCN1", "GDAP1", "GDI1", "GDI2", "GEMIN4", "GEMIN5", "GEMIN8", "GET4", "GFM1", "GFPT1", "GGA1", "GGT7", "GHITM", "GID4", "GIGYF2", "GINS2", "GINS3", "GINS4", "GLB1", "GLCE", "GLDC", "GLE1", "GLG1", "GLMN", "GLO1", "GLOD4", "GLRX5", "GLS", "GLTP", "GLUD1", "GLYR1", "GM2A", "GMFB", "GMPS", "GNA13", "GNAI1", "GNAI2", "GNAI3", "GNAQ", "GNE", "GNG12", "GNL1", "GNL2", "GNL3", "GNL3L", "GNPDA1", "GOLGA2", "GOLGA3", "GOLGA5", "GOLGB1", "GOLIM4", "GOLT1B", "GORASP2", "GOT1", "GPAA1", "GPAM", "GPATCH8", "GPD2", "GPHN", "GPI", "GPKOW", "GPR107", "GPR108", "GPR89B", "GPRASP2", "GPS1", "GPT2", "GPX8", "GRB2", "GRHPR", "GRPEL1", "GRSF1", "GRWD1", "GSK3B", "GSPT1", "GSR", "GSS", "GSTK1", "GSTM3", "GSTZ1", "GTF2E1", "GTF2E2", "GTF2F1", "GTF2H1", "GTF2H4", "GTF2I", "GTF3C1", "GTF3C2", "GTF3C3", "GTF3C4", "GTF3C5", "GTPBP1", "GTPBP3", "GTPBP4", "GUF1", "GYG1", "GYS1", "H1F0", "H1FX", "H2AFY", "H2AFY2", "H4C1*", "HACD3", "HACL1", "HADH", "HADHA", "HADHB", "HARS2", "HAT1", "HAUS1", "HAUS3", "HAUS6", "HAX1", "HBS1L", "HCCS", "HCFC1", "HDAC1", "HDAC2", "HDGF", "HDGFL2", "HDGFL3", "HDHD2", "HDHD5", "HDLBP", "HEATR1", "HEATR3", "HEATR6", "HEBP1", "HECTD1", "HELLS", "HEXA", "HGH1", "HGS", "HIBCH", "HINT2", "HINT3", "HIRA", "HIRIP3", "HIST1H1C", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLTF", "HM13", "HMBS", "HMCES", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMGCS1", "HMGN2", "HMMR", "HMOX1", "HMOX2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPLL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HNRNPUL2", "HOOK2", "HOOK3", "HP1BP3", "HPRT1", "HS2ST1", "HSD17B11", "HSD17B4", "HSDL1", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA1B", "HSPA2", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPBP1", "HSPD1", "HSPH1", "HTATSF1", "HTT", "HUWE1", "IARS", "IARS2", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDH3G", "IFIT5", "IFT81", "IGBP1", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IK", "IKBIP", "IKBKB", "ILF2", "ILF3", "ILK", "ILKAP", "ILVBL", "IMMT", "IMP3", "IMP4", "IMPAD1", "IMPDH1", "IMPDH2", "INA", "INF2", "INPP4A", "INPPL1", "INTS1", "INTS11", "INTS14", "INTS3", "INTS4", "INTS7", "INTS8", "INTS9", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQCB1", "IQGAP1", "IQGAP3", "IRF2BPL", "IRGQ", "ISG20L2", "ISOC1", "IST1", "ISY1", "ISYNA1", "ITCH", "ITGB1", "ITPA", "ITPK1", "ITSN2", "IVD", "IWS1", "JAGN1", "JMJD6", "JPT2", "JUP", "KARS", "KAT7", "KCTD12", "KDELC2", "KDELR1", "KDM1A", "KDM1B", "KDM2A", "KDM3B", "KDM5A", "KHDRBS1", "KHDRBS3", "KHSRP", "KIAA0319L", "KIAA0368", "KIAA0391", "KIAA1147", "KIAA1468", "KIAA2013", "KIDINS220", "KIF11", "KIF14", "KIF18A", "KIF18B", "KIF1A", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF3A", "KIF4A", "KIF5B", "KIN", "KLC1", "KLC4", "KLHL11", "KMT2A", "KNOP1", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNA6", "KPNB1", "KRI1", "KRR1", "KTN1", "KYAT3", "L2HGDH", "L3HYPDH", "LACTB", "LAMC1", "LAMP2", "LAMTOR1", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LAS1L", "LASP1", "LBR", "LCLAT1", "LDHA", "LDHB", "LEMD3", "LETM1", "LGALS3", "LGMN", "LIG1", "LIG3", "LIMA1", "LIN9", "LIPA", "LLPH", "LMF2", "LMNA", "LMNB1", "LMNB2", "LNPK", "LONP1", "LPCAT1", "LRBA", "LRP1", "LRPAP1", "LRPPRC", "LRRC1", "LRRC40", "LRRC47", "LRRC57", "LRRC59", "LRRC8C", "LRSAM1", "LRWD1", "LSM12", "LSM14B", "LSM2", "LSM4", "LSM6", "LSM7", "LTA4H", "LTN1", "LTV1", "LUC7L", "LUC7L2", "LUC7L3", "LYAR", "LYN", "LYPLA1", "LZTFL1", "MACF1", "MAEA", "MAGED2", "MAIP1", "MAK16", "MALT1", "MAN2A1", "MAN2B1", "MANF", "MAP1A", "MAP1B", "MAP1S", "MAP4", "MAPK1", "MAPK14", "MAPRE1", "MAPRE2", "MARC1", "MARCH5", "MARS", "MAT2A", "MAT2B", "MATR3", "MAU2", "MAVS", "MBD3", "MBOAT7", "MCAM", "MCCC1", "MCCC2", "MCL1", "MCM10", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCMBP", "MCU", "MCUB", "MDC1", "MDH1", "MDH2", "MDN1", "ME1", "ME2", "MECP2", "MED14", "MED17", "MED22", "MED23", "MED4", "MEPCE", "MESD", "METAP1", "METAP2", "METTL13", "METTL7B", "METTL9", "MFN1", "MFN2", "MFSD10", "MFSD3", "MGEA5", "MGST2", "MGST3", "MIA2", "MIA3", "MICU1", "MIEF1", "MIF", "MIGA1", "MINDY3", "MIPEP", "MKI67", "MKLN1", "MKRN2", "MMAB", "MMS19", "MOCOS", "MOGS", "MON2", "MORC2", "MORF4L1", "MORF4L2", "MOSPD2", "MOV10", "MPG", "MPHOSPH10", "MPHOSPH6", "MPHOSPH8", "MPI", "MPP1", "MPP2", "MPP7", "MPRIP", "MPST", "MRE11", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL14", "MRPL15", "MRPL19", "MRPL2", "MRPL20", "MRPL21", "MRPL22", "MRPL28", "MRPL37", "MRPL38", "MRPL39", "MRPL40", "MRPL41", "MRPL43", "MRPL44", "MRPL46", "MRPL47", "MRPL48", "MRPL50", "MRPL53", "MRPL58", "MRPL9", "MRPS11", "MRPS16", "MRPS22", "MRPS23", "MRPS25", "MRPS27", "MRPS28", "MRPS31", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRPS9", "MRRF", "MRTO4", "MSH2", "MSH3", "MSH6", "MSI1", "MSI2", "MSMO1", "MSN", "MSTO1", "MTA1", "MTA2", "MTAP", "MTBP", "MTCH2", "MTDH", "MTHFD1L", "MTHFD2", "MTHFS", "MTMR2", "MTO1", "MTOR", "MTPAP", "MTPN", "MTR", "MTX1", "MTX2", "MTX3", "MUL1", "MUT", "MVD", "MYBBP1A", "MYCBP", "MYCBP2", "MYG1", "MYH10", "MYH14", "MYH9", "MYO1B", "MYO1C", "MYO1D", "MYO6", "NAA10", "NAA15", "NAA25", "NAA35", "NAA40", "NAA50", "NAE1", "NAF1", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NAPG", "NARS", "NASP", "NAT10", "NAXE", "NBAS", "NBN", "NCAPD2", "NCAPD3", "NCAPG2", "NCAPH", "NCBP1", "NCBP3", "NCDN", "NCEH1", "NCKAP1", "NCKIPSD", "NCL", "NCLN", "NCOA5", "NCOR1", "NCSTN", "NDC1", "NDC80", "NDUFA10", "NDUFA11", "NDUFA13", "NDUFA4", "NDUFA7", "NDUFA8", "NDUFA9", "NDUFAF2", "NDUFAF4", "NDUFB4", "NDUFB5", "NDUFB6", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS8", "NDUFV1", "NDUFV2", "NECAP2", "NEDD1", "NEFL", "NEFM", "NELFA", "NELFCD", "NELFE", "NEMF", "NES", "NF1", "NFATC2IP", "NFKBIL1", "NFS1", "NFU1", "NFXL1", "NHLRC2", "NIFK", "NIP7", "NIPBL", "NIPSNAP2", "NISCH", "NIT2", "NKRF", "NKTR", "NLE1", "NLN", "NLRX1", "NME1", "NME2", "NMT1", "NNT", "NOA1", "NOB1", "NOC2L", "NOC3L", "NOC4L", "NOL10", "NOL11", "NOL6", "NOL7", "NOL8", "NOL9", "NOLC1", "NOM1", "NONO", "NOP14", "NOP16", "NOP2", "NOP53", "NOP56", "NOP58", "NOP9", "NOSIP", "NOTCH2", "NPC1", "NPEPPS", "NPLOC4", "NPM1", "NRBP1", "NRDC", "NRDE2", "NSA2", "NSD1", "NSD2", "NSD3", "NSDHL", "NSF", "NSMCE2", "NSUN2", "NT5C3A", "NT5DC1", "NTMT1", "NTPCR", "NUB1", "NUBP2", "NUBPL", "NUCB1", "NUCB2", "NUCKS1", "NUDC", "NUDCD1", "NUDCD2", "NUDCD3", "NUDT1", "NUDT16L1", "NUDT21", "NUDT5", "NUF2", "NUFIP2", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP188", "NUP35", "NUP37", "NUP43", "NUP50", "NUP54", "NUP62", "NUP85", "NUP88", "NUPL2", "NUSAP1", "NVL", "NXF1", "NXN", "OARD1", "OAT", "OCIAD1", "OCLN", "OCRL", "ODR4", "OGDH", "OGFOD3", "OGT", "OLA1", "OPA1", "OPA3", "ORC2", "ORC3", "ORC5", "OSBP", "OSBPL11", "OSBPL1A", "OSBPL6", "OSBPL8", "OSBPL9", "OSGEP", "OSTF1", "OTUB1", "OXA1L", "OXSR1", "P3H1", "P3H4", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PAF1", "PAFAH1B1", "PAFAH1B2", "PAFAH1B3", "PAICS", "PAK1IP1", "PAK2", "PALLD", "PANK4", "PAPOLA", "PAPSS1", "PARD3", "PARG", "PARK7", "PARN", "PARP1", "PARP2", "PATL1", "PBDC1", "PBK", "PBRM1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCM1", "PCMT1", "PCNA", "PDAP1", "PDCD11", "PDCD5", "PDCD6", "PDCD6IP", "PDCL3", "PDHA1", "PDHB", "PDHX", "PDIA3", "PDIA4", "PDIA6", "PDK3", "PDLIM1", "PDLIM5", "PDP1", "PDS5A", "PDS5B", "PDSS2", "PDXDC1", "PDZD8", "PEBP1", "PECR", "PEF1", "PELO", "PELP1", "PEPD", "PES1", "PEX11B", "PEX14", "PEX19", "PEX3", "PFAS", "PFDN2", "PFDN5", "PFKL", "PFKM", "PFKP", "PFN1", "PGAM1", "PGAM5", "PGD", "PGLS", "PGM1", "PGM2", "PGM3", "PGP", "PGRMC1", "PGRMC2", "PHB", "PHB2", "PHF10", "PHF2", "PHF3", "PHF5A", "PHF6", "PHGDH", "PHIP", "PHKA1", "PHKB", "PI4K2A", "PI4KA", "PI4KB", "PICALM", "PIGU", "PIH1D1", "PIK3C2A", "PIK3R4", "PIN1", "PIN4", "PINX1", "PIP4K2C", "PIR", "PISD", "PITPNA", "PITPNB", "PITRM1", "PKM", "PKMYT1", "PKN1", "PKN2", "PLA2G15", "PLAA", "PLCG1", "PLD3", "PLEC", "PLEKHA5", "PLIN3", "PLOD1", "PLOD2", "PLRG1", "PLS3", "PM20D2", "PMPCA", "PMPCB", "PNKP", "PNN", "PNO1", "PNP", "PNPLA6", "PNPLA8", "PNPT1", "POFUT1", "POGZ", "POLA1", "POLA2", "POLD1", "POLD2", "POLDIP2", "POLDIP3", "POLE", "POLE2", "POLG", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2B", "POLR2C", "POLR2D", "POLR2E", "POLR2G", "POLR2L", "POLR3A", "POLR3B", "POLR3C", "POLRMT", "POP1", "POP4", "POR", "PPA1", "PPA2", "PPAT", "PPCDC", "PPFIA1", "PPHLN1", "PPIB", "PPID", "PPIE", "PPIF", "PPIG", "PPIL4", "PPM1G", "PPME1", "PPOX", "PPP1CA", "PPP1CB", "PPP1R10", "PPP1R7", "PPP1R8", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP2R5E", "PPP3CA", "PPP4R1", "PPP4R3A", "PPP5C", "PPP6R3", "PPT1", "PPWD1", "PQBP1", "PRAF2", "PRC1", "PRCC", "PRCP", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PREP", "PRIM2", "PRKAA1", "PRKAA2", "PRKACA", "PRKAG1", "PRKAR1A", "PRKCB", "PRKCSH", "PRKDC", "PRMT1", "PRMT5", "PRMT9", "PRPF19", "PRPF3", "PRPF31", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPS2", "PRPSAP1", "PRPSAP2", "PRRC1", "PRRC2A", "PRRC2C", "PSAP", "PSAT1", "PSIP1", "PSMA1", "PSMA4", "PSMA5", "PSMA6", "PSMB1", "PSMB2", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD12", "PSMD13", "PSMD14", "PSMD3", "PSMD4", "PSMD7", "PSMD8", "PSME1", "PSME2", "PSME3", "PSME4", "PSMG1", "PSMG2", "PSPC1", "PTBP1", "PTBP2", "PTCD1", "PTCD3", "PTDSS1", "PTGES2", "PTGES3", "PTGR2", "PTK2", "PTPA", "PTPN1", "PTPN11", "PTPN23", "PTPRF", "PTRH2", "PUF60", "PUM3", "PUS1", "PUS7", "PUS7L", "PWP1", "PWP2", "PXN", "PYCR2", "PYGB", "PYGL", "QARS", "QDPR", "QKI", "QRSL1", "QSOX2", "QTRT2", "R3HCC1", "RAB12", "RAB13", "RAB14", "RAB1A", "RAB1B", "RAB23", "RAB24", "RAB3B", "RAB3GAP1", "RAB3GAP2", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RAB8A", "RAB9A", "RABEPK", "RABGAP1", "RABL3", "RABL6", "RAC1", "RACGAP1", "RACK1", "RAD18", "RAD21", "RAD23A", "RAD23B", "RAD50", "RAD54L2", "RAE1", "RAI14", "RALA", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP6", "RANBP9", "RANGAP1", "RAP1GDS1", "RAPGEF2", "RARS", "RARS2", "RAVER1", "RBBP4", "RBBP5", "RBBP6", "RBBP7", "RBM10", "RBM12", "RBM12B", "RBM14", "RBM17", "RBM19", "RBM22", "RBM25", "RBM26", "RBM27", "RBM28", "RBM3", "RBM34", "RBM39", "RBM4", "RBM45", "RBM47", "RBM5", "RBM6", "RBM8A", "RBMX", "RBMXL1", "RBPJ", "RCC1", "RCL1", "RCN1", "RCN2", "RDH13", "RDH14", "RDX", "RECQL", "REEP4", "REEP5", "RER1", "RETSAT", "REXO2", "REXO4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RFT1", "RHBDD2", "RHOT2", "RIF1", "RINT1", "RIPK1", "RMDN1", "RMDN3", "RNASEH2A", "RNF2", "RNF20", "RNF40", "RNMT", "RNPEP", "RNPS1", "ROBO1", "ROCK2", "RP2", "RPA1", "RPA2", "RPAP1", "RPAP3", "RPF1", "RPF2", "RPL10", "RPL10A", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL32", "RPL34", "RPL35", "RPL36", "RPL36A", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPN1", "RPN2", "RPP30", "RPP38", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS26", "RPS28", "RPS29", "RPS3", "RPS3A", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPSA", "RPTOR", "RPUSD3", "RRAS2", "RRBP1", "RREB1", "RRM1", "RRM2", "RRP1", "RRP12", "RRP15", "RRP1B", "RRP36", "RRP8", "RRP9", "RRS1", "RSBN1", "RSF1", "RSL1D1", "RSL24D1", "RSU1", "RTCA", "RTCB", "RTFDC1", "RTN1", "RTN2", "RTN3", "RTN4", "RTRAF", "RUFY1", "RUVBL1", "RUVBL2", "S100A11", "S100A13", "SAAL1", "SACM1L", "SAE1", "SAFB", "SAFB2", "SALL2", "SAMD4B", "SAMHD1", "SAMM50", "SAP130", "SAP18", "SAP30BP", "SAR1A", "SAR1B", "SARM1", "SARNP", "SARS", "SARS2", "SART1", "SART3", "SBDS", "SBNO1", "SCAF1", "SCAF11", "SCAF4", "SCAMP1", "SCAMP2", "SCAMP3", "SCAMP4", "SCARB1", "SCARB2", "SCCPDH", "SCD", "SCFD2", "SCML2", "SCO2", "SCP2", "SCPEP1", "SCRIB", "SCRN1", "SCYL1", "SDAD1", "SDF4", "SDHA", "SDHB", "SDR39U1", "SEC11A", "SEC16A", "SEC23A", "SEC23B", "SEC23IP", "SEC24A", "SEC24B", "SEC24C", "SEC31A", "SEC61A1", "SEC61B", "SEC62", "SEC63", "SENP3", "SEPT11", "SEPT2", "SEPT7", "SEPT9", "SERBP1", "SERPINB6", "SERPINH1", "SET", "SETD1A", "SETD2", "SETD3", "SETDB1", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFSWAP", "SFXN1", "SFXN2", "SFXN4", "SGF29", "SGPL1", "SGTA", "SH3GL1", "SH3GLB1", "SHCBP1", "SHMT1", "SHMT2", "SHTN1", "SIN3A", "SKA1", "SKA3", "SKIV2L", "SKIV2L2", "SKP1", "SKP2", "SLC12A2", "SLC16A1", "SLC19A1", "SLC1A5", "SLC25A10", "SLC25A12", "SLC25A13", "SLC25A16", "SLC25A17", "SLC25A19", "SLC25A20", "SLC25A24", "SLC25A25", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A4", "SLC25A44", "SLC25A5", "SLC25A6", "SLC27A4", "SLC33A1", "SLC35B2", "SLC35F2", "SLC39A14", "SLC3A2", "SLC4A1AP", "SLC4A2", "SLC5A6", "SLC9A3R1", "SLFN11", "SLIRP", "SLK", "SLMAP", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC5", "SMC6", "SMCHD1", "SMG1", "SMG5", "SMN1*", "SMNDC1", "SMPD4", "SMS", "SMU1", "SND1", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPC", "SNRPD2", "SNRPD3", "SNW1", "SNX1", "SNX17", "SNX19", "SNX2", "SNX27", "SNX5", "SNX6", "SNX9", "SOAT1", "SOD2", "SON", "SORD", "SORT1", "SPAG5", "SPAG9", "SPART", "SPATA5", "SPATA5L1", "SPATS2L", "SPC25", "SPCS2", "SPDL1", "SPECC1L", "SPEN", "SPNS1", "SPPL2A", "SPR", "SPRYD4", "SPTAN1", "SPTBN1", "SPTLC1", "SQLE", "SRC", "SRCAP", "SREK1", "SRI", "SRM", "SRP14", "SRP54", "SRP68", "SRPK1", "SRPK2", "SRPRB", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF3", "SRSF4", "SRSF5", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSR1", "SSR4", "SSRP1", "STAG1", "STAG2", "STAM", "STAM2", "STAT1", "STAT3", "STAU1", "STAU2", "STIP1", "STK26", "STK3", "STK4", "STMN1", "STOM", "STOML2", "STRAP", "STRIP1", "STRN", "STT3B", "STUB1", "STX10", "STX12", "STX16", "STX18", "STX4", "STX7", "STX8", "STXBP2", "STXBP3", "STXBP4", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGP2", "SUGT1", "SUN1", "SUN2", "SUPT16H", "SUPT3H", "SUPT5H", "SUPT6H", "SUPV3L1", "SURF6", "SUZ12", "SV2A", "SYAP1", "SYMPK", "SYNCRIP", "SYNE1", "SYNE2", "SYNGR2", "SYNJ2BP", "TAB1", "TACC3", "TAF15", "TAF6", "TAGLN2", "TALDO1", "TAMM41", "TAP1", "TAP2", "TARBP1", "TARDBP", "TARS", "TARS2", "TARSL2", "TBC1D13", "TBC1D15", "TBC1D4", "TBC1D9B", "TBCA", "TBCB", "TBL1XR1", "TBL2", "TBL3", "TBRG4", "TCAF1", "TCEA1", "TCERG1", "TCOF1", "TCP11L1", "TDRKH", "TECR", "TEFM", "TELO2", "TERF2IP", "TES", "TEX10", "TEX264", "TFAM", "TFCP2", "TFG", "TFIP11", "TFRC", "TGFBRAP1", "TGOLN2", "THADA", "THAP11", "THEM6", "THOC1", "THOC2", "THOC3", "THOC5", "THOC6", "THOP1", "THRAP3", "THUMPD1", "THYN1", "TIA1", "TIAL1", "TIGAR", "TIMM17B", "TIMM23", "TIMM44", "TIMM50", "TJP1", "TJP2", "TKT", "TLE3", "TLN1", "TM9SF3", "TMA16", "TMCO1", "TMED10", "TMED2", "TMEM109", "TMEM11", "TMEM115", "TMEM126A", "TMEM161A", "TMEM167A", "TMEM192", "TMEM201", "TMEM205", "TMEM214", "TMEM230", "TMEM259", "TMEM87A", "TMEM97", "TMLHE", "TMOD3", "TMPPE", "TMX1", "TMX2", "TNKS1BP1", "TNPO1", "TNPO2", "TNPO3", "TOE1", "TOMM20", "TOMM22", "TOMM34", "TOMM40", "TOMM5", "TOMM70", "TOP1", "TOP2A", "TOP2B", "TOPBP1", "TOR1A", "TOR1AIP1", "TOR1B", "TOX4", "TP53", "TP53BP1", "TP53BP2", "TPBG", "TPD52", "TPD52L2", "TPI1", "TPM3", "TPM4", "TPP2", "TPR", "TPT1", "TPX2", "TRA2A", "TRA2B", "TRABD", "TRAF2", "TRAP1", "TRAPPC11", "TRAPPC4", "TRAPPC5", "TRIM21", "TRIM25", "TRIM26", "TRIM27", "TRIM28", "TRIM33", "TRIM4", "TRIO", "TRIP12", "TRIP13", "TRIP4", "TRIR", "TRMT1", "TRMT10C", "TRMT11", "TRMT1L", "TRMT2A", "TRMT6", "TRMU", "TROVE2", "TRRAP", "TRUB1", "TSFM", "TSG101", "TSN", "TSNAX", "TSPAN3", "TSPAN6", "TSR1", "TST", "TTC1", "TTC19", "TTC27", "TTC28", "TTC37", "TTC38", "TTC4", "TTF2", "TTK", "TTLL12", "TUBB", "TUBB2A", "TUBB2B", "TUBB3", "TUBB4A", "TUBB6", "TUBGCP2", "TUFM", "TWF2", "TXLNA", "TXLNG", "TXNDC15", "TXNDC5", "TXNDC9", "TXNL1", "TXNRD1", "U2AF1", "U2AF2", "U2SURP", "UAP1", "UBA1", "UBA2", "UBA3", "UBA6", "UBAC1", "UBAP2L", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2O", "UBE2S", "UBE3A", "UBE3C", "UBE4A", "UBFD1", "UBLCP1", "UBQLN4", "UBR2", "UBR4", "UBR5", "UBTF", "UBXN1", "UBXN4", "UBXN7", "UCHL5", "UCK2", "UFC1", "UFD1", "UFL1", "UGDH", "UGGT1", "UGP2", "UGT8", "UHRF1", "UMPS", "UNC45A", "UPF1", "UPF2", "UPF3B", "UQCC2", "UQCRC1", "UQCRC2", "UQCRFS1", "UQCRQ", "URB1", "URGCP", "UROD", "USMG5", "USO1", "USP10", "USP11", "USP14", "USP24", "USP28", "USP36", "USP39", "USP47", "USP48", "USP5", "USP7", "USP9X", "UTP11", "UTP14A", "UTP15", "UTP18", "UTP20", "UTP3", "UTP4", "UTP6", "UTRN", "VAMP7", "VANGL1", "VAPA", "VAPB", "VARS1", "VARS2", "VBP1", "VCL", "VCP", "VDAC2", "VDAC3", "VIM", "VIRMA", "VPS13C", "VPS26A", "VPS29", "VPS33A", "VPS35", "VPS45", "VPS4A", "VPS4B", "VPS50", "VPS51", "VPS53", "VRK1", "VRK3", "VTA1", "WAPL", "WARS", "WASHC4", "WASHC5", "WBP11", "WBP2", "WDHD1", "WDR1", "WDR11", "WDR12", "WDR18", "WDR26", "WDR3", "WDR33", "WDR36", "WDR4", "WDR41", "WDR46", "WDR5", "WDR6", "WDR61", "WDR7", "WDR74", "WDR77", "WDR82", "WIPI2", "WIZ", "WLS", "WRNIP1", "WTAP", "XAB2", "XPNPEP1", "XPNPEP3", "XPO1", "XPO4", "XPO5", "XPOT", "XRCC1", "XRCC5", "XRCC6", "XRN2", "YARS", "YARS2", "YEATS2", "YEATS4", "YIF1A", "YKT6", "YLPM1", "YME1L1", "YOD1", "YTHDC1", "YTHDC2", "YTHDF2", "YWHAB", "YWHAE", "YWHAG", "YWHAQ", "ZADH2", "ZC3H11A", "ZC3H14", "ZC3H15", "ZC3H18", "ZC3H4", "ZC3H7A", "ZC3HAV1", "ZCCHC11", "ZCCHC3", "ZCCHC8", "ZFR", "ZFYVE16", "ZMYM2", "ZMYM4", "ZNF281", "ZNF318", "ZNF326", "ZNF512B", "ZNF622", "ZNF638", "ZPR1", "ZRANB2", "ZW10", "ZYX", "ZZEF1"], "leading_proteins": ["ABCB6", "ABCD3", "ACBD5", "ACOX3", "AGPS", "ALDH3A2", "ALG1", "ANKLE2", "AP3B1", "APP", "ARL6IP1", "ARL6IP5", "ATL2", "ATP2C1", "ATP6V0A1", "ATP7A", "ATP7B", "BCAP31", "BICD2", "BNIP1", "BRAP", "CALU", "CANX", "CCDC47", "CDS2", "CEP55", "CERS2", "CETN2", "CHKA", "CHST14", "CLCC1", "CLPTM1", "CLPTM1L", "COLEC12", "COMT", "CPVL", "CSGALNACT2", "CYB5B", "CYP51A1", "DDRGK1", "DERL1", "DERL2", "DHCR7", "DNAJC1", "DOLPP1", "EBP", "EFCAB14", "EI24", "EMD", "ENDOD1", "ERAP2", "ERLIN2", "FAF2", "FDFT1", "FKBP14", "FKBP7", "FLOT1", "G6PD", "GALNT4", "GLB1", "GLG1", "GOLGA3", "GOLGA5", "GOLGB1", "GOLIM4", "GPR107", "GPR89B", "HACD3", "HLA-A", "HM13", "HMOX1", "HSDL1", "IKBIP", "ILVBL", "IMPAD1", "INA", "KDELR1", "KIAA0319L", "KIF5B", "LBR", "LMNB1", "LMNB2", "LPCAT1", "LRRC59", "LRRC8C", "MAN2A1", "MAPRE1", "MFSD10", "MGST2", "MIA2", "MPP1", "MSMO1", "MTDH", "NCEH1", "NCLN", "NDC1", "NDUFB4", "NEFL", "NEFM", "NUCB1", "NUCB2", "OCRL", "P3H4", "P4HA1", "P4HA2", "PCM1", "PEX14", "PEX19", "PEX3", "PFDN5", "PGRMC1", "PISD", "PKMYT1", "PLD3", "PPT1", "PRAF2", "PSMD11", "PTDSS1", "QSOX2", "RAB1A", "RABL3", "RCN2", "REEP4", "REEP5", "RER1", "RHBDD2", "RPN1", "RTN1", "RTN3", "RTN4", "SACM1L", "SAR1A", "SCAMP2", "SCARB1", "SCPEP1", "SDF4", "SEC11A", "SEC62", "SET", "SGPL1", "SLC25A17", "SLC39A14", "SNX2", "SPNS1", "SPTLC1", "SSR1", "SSR4", "STX10", "STX12", "STX18", "STX7", "SUN2", "SYNGR2", "TACC3", "TAP1", "TAP2", "TCP11L1", "TECR", "TGOLN2", "TM9SF3", "TMCO1", "TMED10", "TMEM192", "TMEM201", "TMEM205", "TMEM214", "TMEM230", "TMEM259", "TMEM87A", "TMEM97", "TMX1", "TOR1A", "TPD52", "TSPAN3", "TXNDC15", "UBAC1", "VIM", "WLS", "YIF1A", "ZADH2"]} \ No newline at end of file