diff --git a/interpro_active_site/advanced/idx2term.json b/interpro_active_site/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..9e26dfeeb6e641a33dae4961196235bdb965b21b --- /dev/null +++ b/interpro_active_site/advanced/idx2term.json @@ -0,0 +1 @@ +{} \ No newline at end of file diff --git a/interpro_active_site/basic/idx2term.json b/interpro_active_site/basic/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..9e26dfeeb6e641a33dae4961196235bdb965b21b --- /dev/null +++ b/interpro_active_site/basic/idx2term.json @@ -0,0 +1 @@ +{} \ No newline at end of file diff --git a/interpro_active_site/consensus.joblib b/interpro_active_site/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..bc84ab434310d91a80f06d1f24d3ec3638c276d4 --- /dev/null +++ b/interpro_active_site/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:e86545cee6f840dc3838abcd0458e2df22b4181818e46340b088e839c9666750 +size 74373 diff --git a/interpro_active_site/df_merge.tsv b/interpro_active_site/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..c57981107d970e936c6c67aa07afef8fff633223 --- /dev/null +++ b/interpro_active_site/df_merge.tsv @@ -0,0 +1 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 diff --git a/interpro_active_site/metrics.json b/interpro_active_site/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..b8da1c7907eebc4cc3f7a9e72c38bc8fbc9b358f --- /dev/null +++ b/interpro_active_site/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2974, + "annotations_size": 53, + "title": "Average number of proteins per term", + "value": 2.547169811320755 +} \ No newline at end of file diff --git a/interpro_active_site/paths.json b/interpro_active_site/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..bd172e2dec0ec2d1b5db7038a3dde53001632b38 --- /dev/null +++ b/interpro_active_site/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/interpro_active_site/fragment/C220/C220_val_log2fc"} \ No newline at end of file diff --git a/interpro_active_site/result.tsv b/interpro_active_site/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..04f6646032754b595ba2100ee6396b5e11a52cd0 --- /dev/null +++ b/interpro_active_site/result.tsv @@ -0,0 +1,2 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Serine carboxypeptidase, serine active site [IPR018202] 0.8391114102995505 1.2584681372605744 0.2082225034049662 0.9999957736332564 0.3047285400456432 3 Q9HB40,P10619 2 diff --git a/interpro_active_site/selections.json b/interpro_active_site/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..7c35245e8e8dd04262a8e5940d5ae3b4d1523628 --- /dev/null +++ b/interpro_active_site/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["ATP synthase, F0 complex, subunit A, active site [IPR023011]", "ATP-citrate lyase/succinyl-CoA ligase, active site [IPR017440]", "ATP:guanido phosphotransferase active site [IPR022415]", "ATPase, alpha/beta subunit, nucleotide-binding domain, active site [IPR020003]", "Adenylosuccinate synthase, active site [IPR033128]", "Beta-ketoacyl synthase, active site [IPR018201]", "Citrate synthase active site [IPR019810]", "ClpP, Ser active site [IPR018215]", "ClpP, histidine active site [IPR033135]", "Coenzyme A transferase active site [IPR004164]", "Cysteine peptidase, asparagine active site [IPR025661]", "Cysteine peptidase, cysteine active site [IPR000169]", "Cysteine peptidase, histidine active site [IPR025660]", "DNA methylase, C-5 cytosine-specific, active site [IPR018117]", "DNA topoisomerase I, active site [IPR018521]", "Ferrochelatase, active site [IPR019772]", "Glucose-6-phosphate dehydrogenase, active site [IPR019796]", "Glyceraldehyde 3-phosphate dehydrogenase, active site [IPR020830]", "Glycosyl hydrolases family 31, active site [IPR030458]", "Histidine acid phosphatase active site [IPR033379]", "Hydroxymethylglutaryl-CoA lyase, active site [IPR000138]", "Hydroxymethylglutaryl-coenzyme A synthase, active site [IPR000590]", "L-lactate dehydrogenase, active site [IPR018177]", "Leu/Phe/Val dehydrogenases active site [IPR033524]", "Malate dehydrogenase, active site [IPR001252]", "Nucleoside diphosphate kinase, active site [IPR023005]", "Orotidine 5'-phosphate decarboxylase, active site [IPR018089]", "Peptidase S16, active site [IPR008268]", "Peptidase S26A, signal peptidase I, serine active site [IPR019756]", "Peptidase S8, subtilisin, His-active site [IPR022398]", "Peptidase S8, subtilisin, Ser-active site [IPR023828]", "Peptidase S9, serine active site [IPR002471]", "Phosphoglycerate/bisphosphoglycerate mutase, active site [IPR001345]", "Phosphoribosylglycinamide formyltransferase, active site [IPR001555]", "Protein-tyrosine phosphatase, active site [IPR016130]", "Pyridine nucleotide-disulphide oxidoreductase, class I, active site [IPR012999]", "Pyruvate kinase, active site [IPR018209]", "Ribonuclease T2, His active site 1 [IPR018188]", "Ribonuclease T2, His active site 2 [IPR033130]", "Ribonucleotide reductase small subunit, acitve site [IPR030475]", "Serine carboxypeptidase, serine active site [IPR018202]", "Serine carboxypeptidases, histidine active site [IPR033124]", "Serine/threonine-protein kinase, active site [IPR008271]", "Thermonuclease active site [IPR002071]", "Thiolase, active site [IPR020610]", "Thiolase, acyl-enzyme intermediate active site [IPR020615]", "Thymidylate synthase, active site [IPR020940]", "Transaldolase, active site [IPR018225]", "Triosephosphate isomerase, active site [IPR020861]", "Tyrosine-protein kinase, active site [IPR008266]", "Ubiquitin-activating enzyme E1, Cys active site [IPR033127]", "Ubiquitin-conjugating enzyme, active site [IPR023313]", "Uracil-DNA glycosylase, active site [IPR018085]"], "available_proteins": ["ACAA2", "ACAT1", "ACAT2", "ACLY", "ACP2", "ACP6", "ADSS", "AKT2", "APEH", "ARAF", "ATP5A1", "ATP5B", "ATP6", "ATP6V1A", "ATP6V1B2", "AURKA", "AURKB", "BLMH", "CAMK1", "CAMK2G", "CAPN1", "CAPN2", "CDC34", "CDC7", "CDK1", "CDK2", "CDK4", "CDK5", "CDK6", "CKB", "CKMT1A*", "CLPP", "CPVL", "CS", "CSK", "CSNK1A1", "CSNK2A2", "CTSA", "CTSB", "CTSC", "DLD", "DNMT1", "DUSP3", "EIF2AK2", "EPHA7", "FASN", "FECH", "G6PD", "GAA", "GAK", "GANAB", "GAPDH", "GART", "GLUD1", "GSR", "HADHB", "HMGCL", "HMGCS1", "LDHA", "LDHB", "LONP1", "MAP2K2", "MAPK1", "MASTL", "MDH1", "MDH2", "MTMR14", "MTMR2", "NEK9", "NME1", "OXCT1", "PAK2", "PBK", "PGAM1", "PIK3R4", "PKM", "PKMYT1", "PKN1", "PKN2", "PLK1", "PREP", "PRKAA2", "PRKACA", "PRKCB", "PRPF4B", "PTK7", "PTPMT1", "PTPN1", "PTPN11", "PTPRF", "RNASET2", "ROCK1", "RPS6KA1", "RPS6KA3", "RRM2", "SCP2", "SCPEP1", "SEC11A", "SLK", "SND1", "SRPK1", "SRPK2", "SUCLG1", "TALDO1", "TAOK1", "TIGAR", "TOP1", "TPI1", "TPP2", "TTK", "TXNRD1", "TYMS", "UBA1", "UBA2", "UBA3", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2S", "ULK3", "UMPS", "UNG", "VRK1"], "leading_proteins": ["CTSA", "SCPEP1"]} \ No newline at end of file diff --git a/interpro_binding_site/advanced/idx2term.json b/interpro_binding_site/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..1f2df466d020a9613ebb803cec2bf89e8e4d80ca --- /dev/null +++ b/interpro_binding_site/advanced/idx2term.json @@ -0,0 +1 @@ +{"0": "EF-Hand 1, calcium-binding site [IPR018247]"} \ No newline at end of file diff --git a/interpro_binding_site/advanced/plot_0.png b/interpro_binding_site/advanced/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..e95b99c754cf501440b5e82767fb72ce0188f0d3 --- /dev/null +++ b/interpro_binding_site/advanced/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:b207c4a3c019cc8ddabef47128b209182d6007e7f5466fdee151f3ae846cd74e +size 182105 diff --git a/interpro_binding_site/basic/idx2term.json b/interpro_binding_site/basic/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..1f2df466d020a9613ebb803cec2bf89e8e4d80ca --- /dev/null +++ b/interpro_binding_site/basic/idx2term.json @@ -0,0 +1 @@ +{"0": "EF-Hand 1, calcium-binding site [IPR018247]"} \ No newline at end of file diff --git a/interpro_binding_site/basic/plot_0.png b/interpro_binding_site/basic/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..815aef5631330823c1a681ee0cc0efcbb5cbbd8f --- /dev/null +++ b/interpro_binding_site/basic/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:b1024dc96d685de608f3487534acbfcc5828dc87e19486877ff9d580cbd5ee7b +size 136951 diff --git a/interpro_binding_site/consensus.joblib b/interpro_binding_site/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..1c4afa84a06f25d0f9b9116e701cba5491e7f32f --- /dev/null +++ b/interpro_binding_site/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:c58b2f293eafd34a5b3d5977b9c45f064c44aa1ba038a36a9583500f938e7906 +size 70982 diff --git a/interpro_binding_site/df_merge.tsv b/interpro_binding_site/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..6da612ae5f8be763b8113e8ac38382a89c17ee3c --- /dev/null +++ b/interpro_binding_site/df_merge.tsv @@ -0,0 +1,2 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +EF-Hand 1, calcium-binding site [IPR018247] 10 36 2.3175072589139045 0.0204761156912216 10.019417475728156 36.70631067961165 0.9532938980945532 0.3894555773109194 3.76037227687173 3.057484685571999 1.1082350706804749 0.3408841825650379 0.0009224643069731 0.0551599902794207 0.1731294929006003 0.0026393662320255 0.001172270128245 diff --git a/interpro_binding_site/metrics.json b/interpro_binding_site/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..2b49198f956fb9a89e08461fe19360a401b5c6be --- /dev/null +++ b/interpro_binding_site/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2974, + "annotations_size": 31, + "title": "Average number of proteins per term", + "value": 4.32258064516129 +} \ No newline at end of file diff --git a/interpro_binding_site/paths.json b/interpro_binding_site/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..808fde41b1e793069871103aa13db69ad1cc3df4 --- /dev/null +++ b/interpro_binding_site/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/interpro_binding_site/fragment/C220/C220_val_log2fc"} \ No newline at end of file diff --git a/interpro_binding_site/result.tsv b/interpro_binding_site/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..64f9352d8b2d26b30d2d187001e3ed3d8c2957f7 --- /dev/null +++ b/interpro_binding_site/result.tsv @@ -0,0 +1,5 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +EF-Hand 1, calcium-binding site [IPR018247] 0.4926393451091835 2.3175072589139045 0.0204761156912216 0.473418092137227 0.0577054169479882 36 Q9Y680,Q02818,O95202,Q96AY3,Q9NWM8,O95302,Q9BRK5,Q6NUK1,Q14257,P80303 10 +Peptidase M16, zinc-binding site [IPR001431] 0.6779845601081622 1.4250643011888682 0.1541386147353241 0.9944246109547058 0.2884846628974449 5 P22695 1 +Serine hydroxymethyltransferase, pyridoxal phosphate binding site [IPR019798] 0.6554508748317676 0.5461297157331619 0.5849767747024133 0.9999999999985536 0.6253200005439591 2 P34897 1 +Aminotransferase, class-II, pyridoxal-phosphate binding site [IPR001917] 0.5985868102288091 0.3594622889579756 0.7192492841892115 1.0 0.7192492841892115 2 O75600 1 diff --git a/interpro_binding_site/selections.json b/interpro_binding_site/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..58afdaddef834314f19e196bc6fa362ae2636b1c --- /dev/null +++ b/interpro_binding_site/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["2-oxo acid dehydrogenase, lipoyl-binding site [IPR003016]", "2Fe-2S ferredoxin, iron-sulphur binding site [IPR006058]", "6-phosphogluconate-binding site [IPR006184]", "AP endonuclease 1, binding site [IPR020847]", "APOBEC/CMP deaminase, zinc-binding [IPR016192]", "Aconitase family, 4Fe-4S cluster binding site [IPR018136]", "Adenylosuccinate synthase, GTP-binding site [IPR018220]", "Aminotransferase class-V, pyridoxal-phosphate binding site [IPR020578]", "Aminotransferase, class-II, pyridoxal-phosphate binding site [IPR001917]", "Aminotransferases, class-I, pyridoxal-phosphate-binding site [IPR004838]", "Beta tubulin, autoregulation binding site [IPR013838]", "Biotin-binding site [IPR001882]", "Coenzyme A transferase binding site [IPR004163]", "Copper centre Cu(A) [IPR001505]", "Cytochrome b5, heme-binding site [IPR018506]", "Cytochrome c oxidase, subunit Vb, zinc binding site [IPR020893]", "EF-Hand 1, calcium-binding site [IPR018247]", "Fumarate reductase/succinate dehydrogenase, FAD-binding site [IPR003952]", "Hexokinase, binding site [IPR019807]", "IQ motif, EF-hand binding site [IPR000048]", "Inositol monophosphatase, metal-binding site [IPR020583]", "Manganese/iron superoxide dismutase, binding site [IPR019833]", "PPM-type phosphatase, divalent cation binding [IPR000222]", "Peptidase M16, zinc-binding site [IPR001431]", "Peptidase M24A, methionine aminopeptidase, subfamily 2, binding site [IPR018349]", "Porphobilinogen deaminase, dipyrromethane cofactor binding site [IPR022419]", "Protein kinase, ATP binding site [IPR017441]", "RNA polymerases, subunit N, zinc binding site [IPR020789]", "Serine hydroxymethyltransferase, pyridoxal phosphate binding site [IPR019798]", "Sigma-54 interaction domain, ATP-binding site 1 [IPR025662]", "Transketolase binding site [IPR020826]"], "available_proteins": ["ACACA", "ACO1", "ACO2", "ACTN1", "ACTN4", "ADSS", "AKT2", "APEX1", "ARAF", "AURKA", "AURKB", "BPNT1", "CALM3", "CALU", "CAMK1", "CAMK2G", "CAPN1", "CAPN2", "CDC7", "CDK1", "CDK2", "CDK4", "CDK5", "CDK6", "CETN2", "COX2", "COX5B", "CSK", "CSNK1A1", "CSNK2A2", "CYB5B", "DBT", "DCTD", "DLAT", "DLST", "DST", "EHD1", "EHD4", "EIF2AK2", "EPHA7", "EPS15L1", "FKBP10", "FKBP14", "FKBP7", "FKBP9", "GCAT", "GOT1", "GOT2", "GPD2", "HK1", "HK2", "HMBS", "IDE", "ILKAP", "IMPA1", "IQGAP1", "IQGAP2", "LETM1", "MACF1", "MAP2K2", "MAPK1", "MAPK14", "MCCC1", "METAP2", "MICU1", "MYH10", "MYH9", "MYO1B", "MYO1C", "MYO1D", "NRDC", "NUCB1", "NUCB2", "OXCT1", "OXSR1", "PA2G4", "PAK2", "PC", "PCCA", "PDCD6", "PEF1", "PGD", "PKMYT1", "PKN1", "PKN2", "PLCG1", "PLK1", "PLS3", "PMPCA", "PMPCB", "POLR2L", "PPM1G", "PRKAA2", "PRKACA", "PRKCB", "PRKCSH", "PSAT1", "RAB18", "RCN1", "RCN2", "RHOT1", "RHOT2", "ROCK1", "RPS6KA1", "RPS6KA3", "S100A11", "SDF4", "SDHA", "SDHB", "SHMT1", "SHMT2", "SLC25A12", "SLC25A24", "SLK", "SOD2", "SPTAN1", "SPTLC2", "SRI", "SRPK1", "SRPK2", "STK26", "STK4", "TAOK1", "TKT", "TTK", "TUBB", "TUBB2A", "TUBB2B", "TUBB3", "TUBB4B", "TUBB6", "ULK3", "UQCRC2", "VRK1"], "leading_proteins": ["FKBP10", "FKBP14", "FKBP7", "FKBP9", "GCAT", "LETM1", "NUCB1", "NUCB2", "RCN2", "SDF4", "SHMT2", "SLC25A24", "UQCRC2"]} \ No newline at end of file diff --git a/interpro_conserved_site/advanced/idx2term.json b/interpro_conserved_site/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..145d3e094c2aef400b7d961308f40852f8d581eb --- /dev/null +++ b/interpro_conserved_site/advanced/idx2term.json @@ -0,0 +1 @@ +{"0": "Syntaxin/epimorphin, conserved site [IPR006012]"} \ No newline at end of file diff --git a/interpro_conserved_site/advanced/plot_0.png b/interpro_conserved_site/advanced/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..d04a235b0ca083b04520e0608b29636326ae63f9 --- /dev/null +++ b/interpro_conserved_site/advanced/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:b5647eb41a7fed4c7d906af86c0fbcc7c929118512d5ccbc975d948bdf28a911 +size 176964 diff --git a/interpro_conserved_site/basic/idx2term.json b/interpro_conserved_site/basic/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..45bcdc760da5f913f01618565450e47bc8bd2f01 --- /dev/null +++ b/interpro_conserved_site/basic/idx2term.json @@ -0,0 +1 @@ +{"0": "Syntaxin/epimorphin, conserved site [IPR006012]", "1": "Intermediate filament protein, conserved site [IPR018039]"} \ No newline at end of file diff --git a/interpro_conserved_site/basic/plot_0.png b/interpro_conserved_site/basic/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..463fedfce46c3731fe703b4131be9b3222411a0a --- /dev/null +++ b/interpro_conserved_site/basic/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:869dbf344ad10e2f37d239c0afb814e7111fb9fc97f17455c9db2baf52523e53 +size 140548 diff --git a/interpro_conserved_site/basic/plot_1.png b/interpro_conserved_site/basic/plot_1.png new file mode 100644 index 0000000000000000000000000000000000000000..fe37b29f17fa6d68da3a041ce58351fc6736f1d0 --- /dev/null +++ b/interpro_conserved_site/basic/plot_1.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:bbb140d94e6c145397b06f9077f66d14ad6a0b960f6a3cb55cf701d8070d5416 +size 140170 diff --git a/interpro_conserved_site/consensus.joblib b/interpro_conserved_site/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..c2ba7083c50228a89191239dd10eaf6b24157a0f --- /dev/null +++ b/interpro_conserved_site/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:4235c696420bf09eb1ca8779d56aa3f21cf2888de21435090bca24640df97f67 +size 87135 diff --git a/interpro_conserved_site/df_merge.tsv b/interpro_conserved_site/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..2ac7c3a07db4bcb40c310e71e46ba46c8ebf2f54 --- /dev/null +++ b/interpro_conserved_site/df_merge.tsv @@ -0,0 +1,2 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Syntaxin/epimorphin, conserved site [IPR006012] 5 7 2.3053453046365 0.021147242121142 2.592233009708738 5.847087378640777 0.9961908981999794 0.2839139128702306 1.4759357288864456 1.4239341993278547 1.138258151200134 0.2914162845337057 0.0022674499040627 1.0 0.0065261066260236 0.0368360647660487 0.0025257820396667 diff --git a/interpro_conserved_site/metrics.json b/interpro_conserved_site/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..131cfe3c6872c813fbc103fc6adc3a8e018fe9e1 --- /dev/null +++ b/interpro_conserved_site/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2974, + "annotations_size": 270, + "title": "Average number of proteins per term", + "value": 2.6259259259259258 +} \ No newline at end of file diff --git a/interpro_conserved_site/paths.json b/interpro_conserved_site/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..1dbb9b1b18d6f4be060706cc1dab38f3634c3f7a --- /dev/null +++ b/interpro_conserved_site/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/interpro_conserved_site/fragment/C220/C220_val_log2fc"} \ No newline at end of file diff --git a/interpro_conserved_site/result.tsv b/interpro_conserved_site/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..28ec0230744954701399e7d24ec247d8ea5ec486 --- /dev/null +++ b/interpro_conserved_site/result.tsv @@ -0,0 +1,31 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Syntaxin/epimorphin, conserved site [IPR006012] 0.805452902497199 2.3053453046364996 0.021147242121142 0.9968833389912176 0.1520674687809708 7 Q12846,Q9P2W9,Q86Y82,Q13190,O60499 5 +Haem oxygenase conserved site [IPR018207] 0.9639973082099615 1.8123112424761223 0.0699381183961331 0.9999999968508146 0.2863424780865587 2 P30519 1 +Intermediate filament protein, conserved site [IPR018039] 0.6854349291975668 1.7902216913241875 0.0734182793224751 0.9999999988555242 0.2863424780865587 8 P07197,P07196,Q03252,P20700,P02545,P08670,Q16352 7 +Tetraspanin, conserved site [IPR018503] 0.9596095590710167 1.7379756989008786 0.0822150958146266 0.9999999999128945 0.2929856859860177 3 O60637,O43657 2 +Glycoside hydrolase family 27/36, conserved site [IPR000111] 0.8691117092866761 1.409287592086054 0.1587501462533906 1.0 0.4286253948841548 2 P06280 1 +Sterol reductase, conserved site [IPR018083] 0.8522880215343263 1.337721818554238 0.1809871357890031 1.0 0.4527656861606566 2 Q14739 1 +Quinone oxidoreductase/zeta-crystallin, conserved site [IPR002364] 0.8566038323580034 1.328252476403081 0.1840947137133426 1.0 0.4560144284642431 3 Q8N4Q0 1 +Lysosome-associated membrane glycoprotein, conserved site [IPR018134] 0.8209959623149434 1.2050726959340272 0.2281752392941993 1.0 0.4928585168754706 2 P11279 1 +3-hydroxyacyl-CoA dehydrogenase, conserved site [IPR006180] 0.8172947510094216 1.1894455800593078 0.2342643737015519 1.0 0.5019950865033256 2 P40939 1 +Proteinase inhibitor I2, Kunitz, conserved site [IPR020901] 0.7974427994616407 1.1059530069738566 0.2687468599125022 1.0 0.5296470961779242 2 Q06481 1 +Amyloidogenic glycoprotein, intracellular domain, conserved site [IPR019745] 0.7974427994616407 1.1059530069738566 0.2687468599125022 1.0 0.5296470961779242 2 Q06481 1 +Amyloidogenic glycoprotein, copper-binding domain conserved site [IPR019744] 0.7974427994616407 1.1059530069738566 0.2687468599125022 1.0 0.5296470961779242 2 Q06481 1 +Thioredoxin, conserved site [IPR017937] 0.4721723877634032 1.0834338657540803 0.2786158906599689 1.0 0.5417946803775714 12 Q96JJ7,Q9H1E5,Q9H3N1 3 +Guanylate kinase, conserved site [IPR020590] 0.653684501511699 1.0588480223723318 0.2896689991731915 1.0 0.546792277766913 4 Q9NZW5 1 +Proteasome beta-type subunit, conserved site [IPR016050] 0.5436787471126108 1.0576165664408648 0.2902302866961936 1.0 0.546792277766913 8 P49721,P28070 2 +Glycoside hydrolase, family 29, conserved site [IPR018526] 0.766487213997317 0.9772481114045464 0.3284463347099189 1.0 0.5872881481568086 2 Q9BTY2 1 +AMP-binding, conserved site [IPR020845] 0.5069046817110128 0.6274141130566464 0.5303878189903968 1.0 0.749762885483807 5 Q6P1M0,O95573,Q4G176,P33121 4 +Immunoglobulin/major histocompatibility complex, conserved site [IPR003006] 0.6708382006983836 0.6112633000348304 0.5410252831142306 1.0 0.75297333216929 3 P04439 1 +ABC transporter-like, conserved site [IPR017871] 0.4249277868990854 0.5315284938451899 0.595052601385774 1.0 0.7875696194811714 9 P08183,O75027,Q03518,P33527 4 +Histidine triad, conserved site [IPR019808] 0.6100269179004094 0.394376920298059 0.693302780849689 1.0 0.8547568531023563 2 Q96C86 1 +Chromo domain, conserved site [IPR023779] 0.4368474233748724 0.3344256829351684 0.7380583617735774 1.0 0.8856700341282928 5 P83916,Q13185,P45973,Q9HC52 4 +Mrp, conserved site [IPR000808] 0.5360026917900466 0.1970856947486313 0.8437604778150729 1.0 0.9532102555721944 2 Q8TB37 1 +Thiosulphate sulfurtransferase, conserved site [IPR001307] 0.5302826379542508 0.1848793374447869 0.8533236779332543 1.0 0.9599891376749112 2 P25325 1 +Aldehyde dehydrogenase, cysteine active site [IPR016160] 0.3543956031186484 0.1313831921638666 0.895472184114882 1.0 0.9691553568920293 7 P51648 1 +Profilin conserved site [IPR027310] 0.4929340511440145 0.1166259405537898 0.9071564804095728 1.0 0.9712187563165244 2 P35080 1 +Polyprenyl synthetase, conserved site [IPR033749] 0.4724091520861374 0.0874641662049151 0.9303025674674876 1.0 0.9889043040008728 2 O95749 1 +Malic enzyme, conserved site [IPR015884] 0.4576043068640729 0.0699220455081227 0.9442557062934394 1.0 0.9996905191195348 2 P48163 1 +Clathrin adaptor, mu subunit, conserved site [IPR018240] 0.4564119824974646 0.0573576086406506 0.9542603307819256 1.0 0.9996905191195348 3 Q96CW1,Q9Y2T2 2 +Ribosomal S11, conserved site [IPR018102] 0.4131897711978493 0.0328770720390328 0.9737726167719912 1.0 0.9996905191195348 2 P82912 1 +Cyclic nucleotide-binding, conserved site [IPR018488] 0.3543068640645997 0.0105985171377972 0.9915437651214324 1.0 1.0 2 P10644 1 diff --git a/interpro_conserved_site/selections.json b/interpro_conserved_site/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..da05565051d2dc1a90425aca946a50e009ab7b5b --- /dev/null +++ b/interpro_conserved_site/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["14-3-3 protein, conserved site [IPR023409]", "3-hydroxyacyl-CoA dehydrogenase, conserved site [IPR006180]", "3-hydroxyisobutyrate dehydrogenase-related, conserved site [IPR002204]", "4Fe-4S ferredoxin, iron-sulphur binding, conserved site [IPR017900]", "ABC transporter-like, conserved site [IPR017871]", "AMP-binding, conserved site [IPR020845]", "AP endonuclease 1, conserved site [IPR020848]", "AT hook, DNA-binding motif [IPR017956]", "ATP synthase, F1 complex, gamma subunit conserved site [IPR023632]", "ATP-citrate lyase/succinyl-CoA ligase, conserved site [IPR033847]", "ATP-dependent RNA helicase DEAD-box, conserved site [IPR000629]", "ATPase, AAA-type, conserved site [IPR003960]", "ATPase, OSCP/delta subunit, conserved site [IPR020781]", "Acin1, RNSP1-SAP18 binding (RSB) motif [IPR032552]", "Actin, conserved site [IPR004001]", "Actin/actin-like conserved site [IPR020902]", "Actinin-type actin-binding domain, conserved site [IPR001589]", "Acyl-CoA dehydrogenase, conserved site [IPR006089]", "Acyl-CoA-binding protein, ACBP, conserved site [IPR022408]", "Adenylate kinase, conserved site [IPR033690]", "Alanine dehydrogenase/NAD(P) transhydrogenase, conserved site-1 [IPR008142]", "Alanine dehydrogenase/pyridine nucleotide transhydrogenase, conserved site-2 [IPR008143]", "Alcohol dehydrogenase, zinc-type, conserved site [IPR002328]", "Aldehyde dehydrogenase, cysteine active site [IPR016160]", "Aldehyde dehydrogenase, glutamic acid active site [IPR029510]", "Aldo/keto reductase, conserved site [IPR018170]", "Alpha-D-phosphohexomutase, conserved site [IPR016066]", "Aminoacyl-tRNA synthetase, class I, conserved site [IPR001412]", "Amyloidogenic glycoprotein, copper-binding domain conserved site [IPR019744]", "Amyloidogenic glycoprotein, intracellular domain, conserved site [IPR019745]", "Annexin repeat, conserved site [IPR018252]", "Apoptosis regulator, Bcl-2, BH1 motif, conserved site [IPR020717]", "Apoptosis regulator, Bcl-2, BH2 motif, conserved site [IPR020726]", "Apoptosis regulator, Bcl-2, BH3 motif, conserved site [IPR020728]", "ArgE/DapE/ACY1/CPG2/YscS, conserved site [IPR001261]", "BUD31/G10-related, conserved site [IPR018230]", "Bacterial Fmu (Sun)/eukaryotic nucleolar NOL1/Nop2p, conserved site [IPR018314]", "Band 7/stomatin-like, conserved site [IPR018080]", "Bromodomain, conserved site [IPR018359]", "C-type lectin, conserved site [IPR018378]", "CAP, conserved site, C-terminal [IPR028417]", "CAP, conserved site, N-terminal [IPR018106]", "CBX family C-terminal motif [IPR033773]", "Cadherin conserved site [IPR020894]", "Calreticulin/calnexin, conserved site [IPR018124]", "Chaperonin Cpn60, conserved site [IPR018370]", "Chaperonin GroES, conserved site [IPR018369]", "Chaperonin TCP-1, conserved site [IPR002194]", "Chromo domain, conserved site [IPR023779]", "Clathrin adaptor complex, small chain [IPR000804]", "Clathrin adaptor, mu subunit, conserved site [IPR018240]", "Clusterin, conserved site [IPR033986]", "Coproporphyrinogen III oxidase, conserved site [IPR018375]", "Cullin, conserved site [IPR016157]", "Cyclic nucleotide-binding, conserved site [IPR018488]", "Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site [IPR020892]", "Cytochrome P450, conserved site [IPR017972]", "D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site 1 [IPR029752]", "D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site [IPR029753]", "DNA ligase, ATP-dependent, conserved site [IPR016059]", "DNA methylase, C-5 cytosine-specific, conserved site [IPR031303]", "DNA methylase, N-6 adenine-specific, conserved site [IPR002052]", "DNA mismatch repair, conserved site [IPR014762]", "DNA topoisomerase, type IIA, conserved site [IPR018522]", "DNA-directed DNA polymerase, family B, conserved site [IPR017964]", "DNA-directed RNA polymerase, 14-18kDa subunit, conserved site [IPR020708]", "DNA-directed RNA polymerase, 30-40kDa subunit, conserved site [IPR001514]", "DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site [IPR002464]", "Dihydrofolate reductase conserved site [IPR017925]", "Dihydroorotase, conserved site [IPR002195]", "DnaJ domain, conserved site [IPR018253]", "Dynamin, GTPase region, conserved site [IPR019762]", "Dynein light chain, type 1/2, conserved site [IPR019763]", "EGF-like calcium-binding, conserved site [IPR018097]", "EGF-like, conserved site [IPR013032]", "Electron transfer flavoprotein subunit alpha, conserved site [IPR018206]", "Electron transfer flavoprotein, beta-subunit, conserved site [IPR000049]", "Endonuclease III-like, conserved site-2 [IPR004036]", "Endonuclease III-like, iron-sulphur cluster loop motif [IPR003651]", "Enolase, conserved site [IPR020809]", "Enoyl-CoA hydratase/isomerase, conserved site [IPR018376]", "Ependymin, conserved site [IPR018224]", "Eukaryotic translation initiation factor 4E (eIF-4E), conserved site [IPR019770]", "F-actin capping protein, alpha subunit, conserved site [IPR017865]", "F-actin capping protein, beta subunit, conserved site [IPR019771]", "FERM conserved site [IPR019747]", "FLAP/GST2/LTC4S, conserved site [IPR018295]", "Fatty acid desaturase type 1, conserved site [IPR001522]", "Ferritin, conserved site [IPR014034]", "Fibrillarin, conserved site [IPR020813]", "Formate-tetrahydrofolate ligase, FTHFS, conserved site [IPR020628]", "Fructose-bisphosphate aldolase class-I active site [IPR029768]", "Fumarate lyase, conserved site [IPR020557]", "GHMP kinase, ATP-binding, conserved site [IPR006203]", "GTP1/OBG, conserved site [IPR006074]", "Galactokinase, conserved site [IPR019741]", "Gamma-glutamyl phosphate reductase GPR, conserved site [IPR020593]", "Glucosamine-6-phosphate isomerase, conserved site [IPR018321]", "Glutamate 5-kinase, conserved site [IPR019797]", "Glycoside hydrolase family 27/36, conserved site [IPR000111]", "Glycoside hydrolase, family 29, conserved site [IPR018526]", "Glycoside hydrolase, family 35, conserved site [IPR019801]", "Glycosyl hydrolases family 31, conserved site [IPR030459]", "Glyoxalase I, conserved site [IPR018146]", "Golgin subfamily A member 2, C-terminal binding motif [IPR043937]", "Guanylate kinase, conserved site [IPR020590]", "HIND motif [IPR045347]", "HMG box A DNA-binding domain, conserved site [IPR017967]", "HMG-I/HMG-Y, DNA-binding, conserved site [IPR000637]", "Haem oxygenase conserved site [IPR018207]", "Heat shock protein 70, conserved site [IPR018181]", "Heat shock protein Hsp90, conserved site [IPR019805]", "Heavy-metal-associated, conserved site [IPR017969]", "Helix-hairpin-helix motif [IPR000445]", "Helix-hairpin-helix motif, class 2 [IPR008918]", "Hexapeptide transferase, conserved site [IPR018357]", "Histidine triad, conserved site [IPR019808]", "Histone H2A conserved site [IPR032458]", "Histone H4, conserved site [IPR019809]", "Hydroxymethylglutaryl-CoA reductase, class I/II, conserved site [IPR023076]", "IMP dehydrogenase / GMP reductase, conserved site [IPR015875]", "Immunoglobulin/major histocompatibility complex, conserved site [IPR003006]", "Inositol monophosphatase, conserved site [IPR020550]", "Intermediate filament protein, conserved site [IPR018039]", "Isocitrate/isopropylmalate dehydrogenase, conserved site [IPR019818]", "Kinesin motor domain, conserved site [IPR019821]", "Lipocalin family conserved site [IPR022272]", "Low-density lipoprotein (LDL) receptor class A, conserved site [IPR023415]", "Lysophospholipase patatin, conserved site [IPR001423]", "Lysosome-associated membrane glycoprotein, conserved site [IPR018134]", "Macrophage migration inhibitory factor, conserved site [IPR019829]", "Malic enzyme, conserved site [IPR015884]", "Methylthiotransferase, conserved site [IPR020612]", "Mini-chromosome maintenance, conserved site [IPR018525]", "Mitogen-activated protein (MAP) kinase, conserved site [IPR003527]", "Molybdenum cofactor biosynthesis, conserved site [IPR008284]", "Mrp, conserved site [IPR000808]", "Myristoyl-CoA:protein N-myristoyltransferase, conserved site [IPR022678]", "NADH:ubiquinone oxidoreductase, 30kDa subunit, conserved site [IPR020396]", "NADH:ubiquinone oxidoreductase, 49kDa subunit, conserved site [IPR014029]", "NADH:ubiquinone oxidoreductase, 51kDa subunit, conserved site [IPR001949]", "NADH:ubiquinone oxidoreductase, 75kDa subunit, conserved site [IPR000283]", "NADH:ubiquinone oxidoreductase, subunit 1, conserved site [IPR018086]", "NUDIX hydrolase, conserved site [IPR020084]", "Oxysterol-binding protein, conserved site [IPR018494]", "P-type trefoil, conserved site [IPR017957]", "Peptidase M22, conserved site [IPR017860]", "Peptidase M24B, X-Pro dipeptidase/aminopeptidase P, conserved site [IPR001131]", "Peptidase S26A, signal peptidase I, conserved site [IPR019758]", "Phosphatidylethanolamine-binding, conserved site [IPR001858]", "Phosphatidylinositol 3/4-kinase, conserved site [IPR018936]", "Phosphoenolpyruvate carboxykinase, GTP-utilising, conserved site [IPR018091]", "Phosphofructokinase, conserved site [IPR015912]", "Phosphoglucose isomerase, conserved site [IPR018189]", "Phosphoglycerate kinase, conserved site [IPR015911]", "Phosphomannose isomerase, type I, conserved site [IPR018050]", "Phosphoribosylglycinamide synthetase, conserved site [IPR020559]", "Phosphorylase pyridoxal-phosphate attachment site [IPR035090]", "Polyamine biosynthesis domain, conserved site [IPR030373]", "Polyprenyl synthetase, conserved site [IPR033749]", "Procollagen-lysine 5-dioxygenase, conserved site [IPR001006]", "Profilin conserved site [IPR027310]", "Proliferating cell nuclear antigen, PCNA, conserved site [IPR022659]", "Proteasome beta-type subunit, conserved site [IPR016050]", "Protein phosphatase 2A regulatory subunit PR55, conserved site [IPR018067]", "Proteinase inhibitor I2, Kunitz, conserved site [IPR020901]", "Proteinase inhibitor I25, cystatin, conserved site [IPR018073]", "Pseudouridine synthase TruD, conserved site [IPR020119]", "Purine phosphorylase, family 2, conserved site [IPR018099]", "Quinone oxidoreductase/zeta-crystallin, conserved site [IPR002364]", "RNA 3'-terminal phosphate cyclase-like, conserved site [IPR020719]", "RNA polymerase, beta subunit, conserved site [IPR007121]", "RNA polymerase, subunit H/Rpb5, conserved site [IPR020608]", "Ras GTPase-activating protein, conserved site [IPR023152]", "Retro-transposon transporting motif [IPR018892]", "Ribonuclease II/R, conserved site [IPR022966]", "Ribosomal RNA adenine methylase transferase, conserved site [IPR020596]", "Ribosomal S11, conserved site [IPR018102]", "Ribosomal S24e conserved site [IPR018098]", "Ribosomal protein L1, conserved site [IPR023673]", "Ribosomal protein L10e, conserved site [IPR018255]", "Ribosomal protein L11, conserved site [IPR020785]", "Ribosomal protein L13, conserved site [IPR023563]", "Ribosomal protein L13e, conserved site [IPR018256]", "Ribosomal protein L14P, conserved site [IPR019972]", "Ribosomal protein L15, conserved site [IPR001196]", "Ribosomal protein L15e, conserved site [IPR020925]", "Ribosomal protein L18e, conserved site [IPR021132]", "Ribosomal protein L19/L19e conserved site [IPR023638]", "Ribosomal protein L2, conserved site [IPR022671]", "Ribosomal protein L21e, conserved site [IPR018259]", "Ribosomal protein L22/L17, conserved site [IPR018260]", "Ribosomal protein L23/L25, conserved site [IPR001014]", "Ribosomal protein L24/L26, conserved site [IPR005825]", "Ribosomal protein L24e, conserved site [IPR023442]", "Ribosomal protein L27e, conserved site [IPR018262]", "Ribosomal protein L29, conserved site [IPR018254]", "Ribosomal protein L3, conserved site [IPR019926]", "Ribosomal protein L30, conserved site [IPR018038]", "Ribosomal protein L30e, conserved site [IPR022991]", "Ribosomal protein L31e, conserved site [IPR020052]", "Ribosomal protein L32e, conserved site [IPR018263]", "Ribosomal protein L34e, conserved site [IPR018065]", "Ribosomal protein L35Ae, conserved site [IPR018266]", "Ribosomal protein L37e, conserved site [IPR018267]", "Ribosomal protein L4/L1e, eukaryotic/archaeal, conserved site [IPR013000]", "Ribosomal protein L5, conserved site [IPR020929]", "Ribosomal protein L6, conserved site-2 [IPR002359]", "Ribosomal protein L7Ae conserved site [IPR004037]", "Ribosomal protein S10, conserved site [IPR018268]", "Ribosomal protein S13, conserved site [IPR018269]", "Ribosomal protein S14, conserved site [IPR018271]", "Ribosomal protein S17, conserved site [IPR019979]", "Ribosomal protein S17e, conserved site [IPR018273]", "Ribosomal protein S19e, conserved site [IPR018277]", "Ribosomal protein S2, conserved site [IPR018130]", "Ribosomal protein S21e, conserved site [IPR018279]", "Ribosomal protein S28e conserved site [IPR028626]", "Ribosomal protein S3, conserved site [IPR018280]", "Ribosomal protein S3Ae, conserved site [IPR018281]", "Ribosomal protein S4, conserved site [IPR018079]", "Ribosomal protein S4e, N-terminal, conserved site [IPR018199]", "Ribosomal protein S5, N-terminal, conserved site [IPR018192]", "Ribosomal protein S6e, conserved site [IPR018282]", "Ribosomal protein S7, conserved site [IPR020606]", "Ribosomal protein S8e, conserved site [IPR018283]", "Ribosomal protein S9, conserved site [IPR020574]", "Ribosome maturation protein SBDS, conserved site [IPR018023]", "RidA, conserved site [IPR019897]", "S-adenosyl-L-homocysteine hydrolase, conserved site [IPR020082]", "S-adenosylmethionine synthetase, conserved site [IPR022631]", "S100/Calbindin-D9k, conserved site [IPR001751]", "SAICAR synthetase, conserved site [IPR018236]", "SecY conserved site [IPR030659]", "Serpin, conserved site [IPR023795]", "Short-chain dehydrogenase/reductase, conserved site [IPR020904]", "Sodium:dicarboxylate symporter, conserved site [IPR018107]", "Squalene/phytoene synthase, conserved site [IPR019845]", "Stathmin, conserved site [IPR030514]", "Sterol reductase, conserved site [IPR018083]", "Succinyl-CoA synthetase, beta subunit, conserved site [IPR017866]", "Sugar transporter, conserved site [IPR005829]", "Sulfatase, conserved site [IPR024607]", "Syntaxin/epimorphin, conserved site [IPR006012]", "TPP-binding enzyme, conserved site [IPR000399]", "Terpene synthase, conserved site [IPR002365]", "Tetrahydrofolate dehydrogenase/cyclohydrolase, conserved site [IPR020867]", "Tetraspanin, conserved site [IPR018503]", "Thiolase, conserved site [IPR020613]", "Thioredoxin, conserved site [IPR017937]", "Thiosulphate sulfurtransferase, conserved site [IPR001307]", "Thymidine kinase, conserved site [IPR020633]", "Thymidylate kinase, conserved site [IPR018095]", "Tr-type G domain, conserved site [IPR031157]", "Transcription factor TFIIB, conserved site [IPR023486]", "Translation elongation factor EF1B, beta/delta chains, conserved site [IPR001326]", "Translation elongation factor Ts, conserved site [IPR018101]", "Translationally controlled tumour protein, conserved site [IPR018103]", "Tubulin, conserved site [IPR017975]", "Tyrosine-protein kinase, receptor class V, conserved site [IPR001426]", "UbiE/COQ5 methyltransferase, conserved site [IPR023576]", "Ubiquitin conserved site [IPR019954]", "Ubiquitin interacting motif [IPR003903]", "Ubiquitin specific protease, conserved site [IPR018200]", "Ubiquitin-activating enzyme E1, conserved site [IPR018074]", "Vinculin, conserved site [IPR000633]", "WD40 repeat, conserved site [IPR019775]", "XPG conserved site [IPR019974]", "Zinc finger, PHD-type, conserved site [IPR019786]", "Zinc finger, RING-type, conserved site [IPR017907]"], "available_proteins": ["AAAS", "AAMP", "ABCB1", "ABCB7", "ABCC1", "ABCD3", "ABCE1", "ABCF1", "ABCF2", "ABCF3", "ACAA2", "ACAD9", "ACADM", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACBD5", "ACIN1", "ACLY", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN4", "ACTR1A", "ACTR1B", "ACTR2", "ACTR3", "ADH5", "ADSL", "AFG3L2", "AHCY", "AHCYL1", "AK1", "AK2", "AKR1A1", "AKR1B1", "ALDH18A1", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ANXA1", "ANXA11", "ANXA2", "ANXA3", "ANXA4", "ANXA6", "ANXA7", "AP1M1", "AP1S2", "AP2M1", "AP2S1", "AP3M1", "AP3S1", "APEX1", "APLP2", "APP", "ARIH2", "ATAD1", "ATAD2", "ATP5C1", "ATP5O", "ATP7B", "BAG6", "BAK1", "BAZ1A", "BAZ1B", "BCS1L", "BOP1", "BPNT1", "BRD2", "BUD31", "CAD", "CALR", "CANX", "CAP1", "CAPZA1", "CAPZA2", "CAPZB", "CASK", "CBR1", "CBX1", "CBX3", "CBX5", "CBX8", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD320", "CDC40", "CDH2", "CDKAL1", "CECR2", "CETN2", "CHAF1B", "CHD1", "CHD1L", "CHD4", "CLGN", "CLU", "CMPK1", "CNDP2", "COLEC12", "COPA", "COPZ1", "CORO1B", "CORO1C", "CORO7", "CPOX", "CSTB", "CTBP1", "CTBP2", "CTNNA1", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CWC27", "CYP51A1", "DCAF13", "DCAF7", "DCPS", "DCXR", "DDT", "DDX10", "DDX17", "DDX18", "DDX20", "DDX23", "DDX24", "DDX27", "DDX3X", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX51", "DDX54", "DDX55", "DDX6", "DHCR7", "DHFR", "DHRS4", "DHRS7", "DHRS7B", "DHX15", "DHX16", "DHX29", "DHX30", "DHX36", "DHX38", "DHX40", "DHX57", "DHX8", "DHX9", "DIDO1", "DIMT1", "DIS3", "DLG3", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC2", "DNAJC9", "DNM1L", "DNM2", "DNMT1", "DRG1", "DRG2", "DSC3", "DSG2", "DST", "DTYMK", "DYNLL2", "EARS2", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "EEF1A2", "EEF1B2", "EEF1D", "EEF2", "EIF3I", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4E", "ENO1", "ENO2", "EPB41", "EPB41L2", "EPB41L3", "EPB41L5", "EPDR1", "EPHA7", "EPRS", "ERCC2", "ETFA", "ETFB", "EXO1", "EZR", "FARP1", "FBL", "FCGRT", "FDFT1", "FDPS", "FEN1", "FH", "FLNA", "FLNB", "FLNC", "FTL", "FUCA1", "FUCA2", "GAA", "GALK1", "GANAB", "GART", "GCDH", "GEMIN5", "GFM1", "GGPS1", "GLA", "GLB1", "GLO1", "GMPPB", "GNPDA1", "GNS", "GOLGA2", "GPHN", "GPI", "GRHPR", "GRWD1", "GSPT1", "GTF2B", "GTF3C2", "GUF1", "H2AFX", "H4C1*", "HADH", "HADHA", "HADHB", "HGS", "HIBADH", "HINT2", "HLA-A", "HLA-B", "HLTF", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMGCR", "HMOX1", "HMOX2", "HSD17B10", "HSD17B12", "HSD17B4", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA13", "HSPA14", "HSPA1B", "HSPA2", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPD1", "HSPE1", "HSPH1", "HYOU1", "IARS", "IARS2", "IDH1", "IDH2", "IDH3A", "IDH3B", "ILVBL", "IMPA1", "IMPAD1", "IMPDH1", "IMPDH2", "INA", "IQGAP1", "IQGAP2", "IVD", "KDM2A", "KDSR", "KIF11", "KIF14", "KIF18B", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF4A", "KIF5B", "KIFC1", "LAMP1", "LAMP2", "LARS", "LARS2", "LBR", "LIG1", "LIG3", "LMNA", "LMNB1", "LMNB2", "LRP1", "LRWD1", "LSS", "MACF1", "MAPK1", "MAPK14", "MARS", "MAT2A", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "ME1", "ME2", "MGST2", "MIF", "MKRN2", "MPI", "MPP1", "MPP6", "MPST", "MRC2", "MRPL24", "MRPL3", "MRPS11", "MRPS5", "MRPS9", "MSN", "MTAP", "MTHFD1", "MTHFD1L", "MTHFD2", "MTOR", "MVK", "NAGA", "ND1", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS8", "NDUFV1", "NEFL", "NEFM", "NES", "NKTR", "NLE1", "NMT1", "NNT", "NOP2", "NSD2", "NSF", "NTHL1", "NUBP2", "NUBPL", "NUDT1", "NUDT5", "NUP153", "NUP37", "NUP43", "NVL", "OSBP", "OSBPL3", "OSBPL6", "OSBPL8", "OSBPL9", "OSGEP", "P4HB", "PAFAH1B1", "PAICS", "PAK1IP1", "PBRM1", "PCK2", "PCNA", "PDIA3", "PDIA4", "PDIA5", "PDIA6", "PEBP1", "PEPD", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGK1", "PGM1", "PGM2", "PGM3", "PHGDH", "PHIP", "PI4KB", "PLEC", "PLOD1", "PLOD2", "PLRG1", "PLS3", "PNP", "PNPLA6", "POLA1", "POLD1", "POLR1B", "POLR1C", "POLR2B", "POLR2C", "POLR2E", "POLR2F", "PPIB", "PPIC", "PPID", "PPIF", "PPIH", "PPIL1", "PPIL3", "PPP2R2A", "PRKAR1A", "PRKAR2A", "PRKDC", "PRPF19", "PRPF4", "PSMA4", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD4", "PUS7", "PWP1", "PWP2", "PYGB", "PYGL", "QARS", "RACK1", "RAE1", "RANBP2", "RARS", "RARS2", "RBBP7", "RCL1", "RDH13", "RDX", "RIDA", "RNF14", "RNF20", "RNF40", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL15", "RPL17", "RPL18", "RPL19", "RPL21", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL37", "RPL4", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPS11", "RPS14", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS24", "RPS28", "RPS29", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS8", "RPS9", "RPSA", "RRP8", "RRP9", "RSL24D1", "RTN4IP1", "S100A11", "SART1", "SBDS", "SCD", "SCP2", "SDHB", "SEC11A", "SEC61A1", "SERPINB6", "SERPINH1", "SLC1A5", "SLC25A42", "SLC27A4", "SLIT2", "SMARCA4", "SMS", "SMU1", "SNRNP40", "SORD", "SPATA5", "SPATA5L1", "SPTBN1", "SPTBN2", "SRCAP", "SRM", "STAM", "STMN1", "STOM", "STRN", "STX10", "STX12", "STX18", "STX3", "STX4", "STX5", "STX7", "SUCLA2", "SUCLG1", "SUCLG2", "SV2A", "SYNE2", "TAP1", "TBL3", "TCP1", "TFB1M", "THOC6", "TK1", "TLN1", "TMX1", "TMX3", "TMX4", "TOP2A", "TOP2B", "TPT1", "TRAF2", "TRIM21", "TRIM25", "TRIM28", "TRIM33", "TRIP13", "TRMT11", "TSFM", "TSPAN10", "TSPAN3", "TSPAN6", "TST", "TUBB", "TUBB2A", "TUBB2B", "TUBB3", "TUBB4B", "TUBB6", "TUFM", "TXNDC12", "TXNDC5", "TXNL1", "UBA1", "UBA2", "UHRF1", "USP10", "USP11", "USP14", "USP28", "USP36", "USP47", "USP48", "USP5", "USP7", "USP9X", "UTP15", "UTP18", "UTRN", "VARS1", "VAT1", "VCL", "VCP", "VIM", "VPS4A", "VPS4B", "WARS", "WDHD1", "WDR1", "WDR11", "WDR12", "WDR18", "WDR3", "WDR36", "WDR41", "WDR48", "WDR5", "WDR61", "WDR77", "XPNPEP1", "YARS2", "YME1L1", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2"], "leading_proteins": ["ABCB1", "ABCB7", "ABCC1", "ACSF3", "ACSL1", "ACSL3", "ALDH3A2", "AP2M1", "AP3M1", "APLP2", "CBX1", "CBX3", "CBX5", "CBX8", "DCPS", "FUCA2", "GGPS1", "GLA", "HADHA", "HLA-A", "HMOX2", "INA", "LAMP1", "LBR", "LMNA", "LMNB1", "LMNB2", "ME1", "MPP6", "MPST", "MRPS11", "NEFL", "NEFM", "NUBPL", "PFN2", "PRKAR1A", "PSMB2", "PSMB4", "SLC27A4", "STX10", "STX12", "STX18", "STX4", "STX5", "TAP1", "TMX1", "TMX3", "TMX4", "TSPAN3", "TSPAN6", "VIM", "ZADH2"]} \ No newline at end of file diff --git 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a/interpro_domain/consensus.joblib b/interpro_domain/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..162ec768b240935ba691e33f86a7e781c5dad621 --- /dev/null +++ b/interpro_domain/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:c621c03b8a5fa44051e916b37bf5e1e27542197a8334821368e4931c644010b3 +size 298497 diff --git a/interpro_domain/df_merge.tsv b/interpro_domain/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..70f1ef83fce35979a68b6770771d345199f157a0 --- /dev/null +++ b/interpro_domain/df_merge.tsv @@ -0,0 +1,7 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +EF-hand domain [IPR002048] 14 42 2.903306032804643 0.0036924562104008 12.385922330097088 43.512135922330096 1.0171858714399242 0.3947118087831401 4.608360476919044 4.087317384177653 1.201458704248258 0.3652478399429377 4.805909081633214e-05 0.0832266786690803 0.2461545823107532 0.0005989342875991 6.71908161905798e-05 +FKBP-type peptidyl-prolyl cis-trans isomerase domain [IPR001179] 4 11 2.4880667042620086 0.0128439640366668 3.1262135922330097 10.111650485436892 0.9686720267359892 0.3700536707457866 1.7316562118191232 1.203619216216406 0.9607394322697528 0.3108814801432357 0.0001907872283095 0.0607401038440192 0.1169218221283287 0.0031665778749487 0.0002190726437552 +Cytochrome b5-like heme/steroid binding domain [IPR001199] 4 6 2.1687478005237395 0.0301018361917864 2.813106796116505 6.104368932038835 1.6405397264547834 0.1100883340733615 1.2852875686886795 0.8042848477475721 1.100790504333474 0.1612592696854457 0.000122001793767 0.0561990347849709 0.0055563644779973 0.0024789777341693 0.0001402534450405 +P-type ATPase, haloacid dehalogenase domain [IPR044492] 4 5 2.063733772997012 0.039042965342845 2.941747572815534 6.145631067961165 0.9567723497044874 0.2732808833570771 1.8358630293390923 1.459204245106796 1.2102525517005158 0.2943240638910574 0.0167170186699105 1.0 1.0 0.4108142183097444 0.0184399659986801 +Band 7 domain [IPR001107] 7 8 2.034318154650474 0.0419195279005741 3.825242718446602 7.354368932038835 0.2848798017769268 0.3662852929750465 1.8717479731706237 0.7075565364256523 1.25010454777189 0.3076860385713043 0.0065989327860597 1.0 1.0 1.0 0.0071635939680117 +Tim10-like [IPR004217] 3 5 1.9892556971379796 0.0466729870130147 1.2005141388174807 2.5167095115681235 0.6297728943083764 0.3036466482483842 1.011959204869136 1.1903007636326162 1.51035532787006 0.2968335314780513 0.0017428204603846 1.0 0.0557540441617295 0.1342523552784823 0.001897897013483 diff --git a/interpro_domain/metrics.json b/interpro_domain/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..2cb37a09b2143b3e366c4035c1bd76e54bd2af66 --- /dev/null +++ b/interpro_domain/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2974, + "annotations_size": 2448, + "title": "Average number of proteins per term", + "value": 2.110294117647059 +} \ No newline at end of file diff --git a/interpro_domain/paths.json b/interpro_domain/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..a011e49dd7e69ae5e6e47ca9b70250566d629d98 --- /dev/null +++ b/interpro_domain/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/interpro_domain/fragment/C220/C220_val_log2fc"} \ No newline at end of file diff --git a/interpro_domain/result.tsv b/interpro_domain/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..e3becac7fc3a498964a5cdb54ef5d31e21a6841c --- /dev/null +++ b/interpro_domain/result.tsv @@ -0,0 +1,169 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +EF-hand domain [IPR002048] 0.5433391212156761 2.903306032804643 0.0036924562104008 0.9998832951311823 0.141331215100908 42 Q9Y680,Q02818,Q9UJS0,O75071,Q8IYU8,O95202,Q96AY3,Q8NF37,Q9NWM8,O95302,Q9BRK5,Q6NUK1,Q14257,P80303 14 +FKBP-type peptidyl-prolyl cis-trans isomerase domain [IPR001179] 0.7208920730359976 2.4880667042620086 0.0128439640366668 0.999999999999982 0.141331215100908 11 Q96AY3,Q9Y680,Q9NWM8,O95302 4 +TRAM/LAG1/CLN8 homology domain [IPR006634] 0.9242424242424294 2.224973128168226 0.0260830421438549 1.0 0.1522952529404522 4 Q96CP7,Q15629,Q96G23 3 +Cytochrome b5-like heme/steroid binding domain [IPR001199] 0.7900241226067679 2.1687478005237395 0.0301018361917864 1.0 0.1583709173144682 6 O43169,O15173,O00264,O95864 4 +P-type ATPase, haloacid dehalogenase domain [IPR044492] 0.8174469518356344 2.063733772997012 0.039042965342845 1.0 0.1793192854770817 5 P35670,P05023,Q9HD20,P16615 4 +Band 7 domain [IPR001107] 0.7346594740391011 2.034318154650474 0.0419195279005741 1.0 0.1848647838592249 8 Q14254,Q9UJZ1,P27105,P35232,Q99623,O75477,O75955 7 +Tim10-like [IPR004217] 0.8007719439061067 1.9892556971379791 0.0466729870130147 1.0 0.1982393197971919 5 Q9Y5J9,Q9Y5J6,Q9Y5J7 3 +LEM domain [IPR003887] 0.7426594526830846 1.9475700479836804 0.0514664305740926 1.0 0.2089383450172117 6 P42167,Q86XL3 2 +ABC transporter type 1, transmembrane domain [IPR011527] 0.7878073425395749 1.9309641692697916 0.053487483608904 1.0 0.2150377541826532 5 P08183,O75027,Q03518,P33527 4 +Target SNARE coiled-coil homology domain [IPR000727] 0.6634737811861067 1.8266783862988416 0.0677481398442967 1.0 0.2516653206962646 9 Q12846,Q86Y82,Q13190,O60499,Q9UNK0 5 +Intermediate filament, rod domain [IPR039008] 0.6854349291975668 1.7902216913241875 0.0734182793224751 1.0 0.2635307152220221 8 P07197,P07196,Q03252,P20700,P02545,P08670,Q16352 7 +MENTAL domain [IPR019498] 0.9512113055181723 1.7582645317640118 0.0787025096365168 1.0 0.2750845121966474 2 O95772 1 +Syntaxin, N-terminal domain [IPR006011] 0.8028800104594825 1.7122984557013017 0.0868416811367065 1.0 0.2880602105998071 4 Q86Y82,Q12846 2 +Immunoglobulin-like domain [IPR007110] 0.6084428732481896 1.6859094745423766 0.0918132367723809 1.0 0.2973400216428712 10 P01889,P35613,P10321,P04439,Q08722 5 +GMP phosphodiesterase, delta subunit [IPR008015] 0.9414338606529752 1.666093155292813 0.0956948616304087 1.0 0.3003127665377353 3 Q13432,A6NIH7 2 +Reticulon [IPR003388] 0.9269606193200888 1.6086804985543997 0.1076862221487673 1.0 0.3172532421682301 3 O95197,Q9NQC3 2 +Ricin B, lectin domain [IPR000772] 0.7090108402664044 1.5699351537604165 0.1164301982020972 1.0 0.3267223427158505 5 Q8N4A0 1 +START domain [IPR002913] 0.904104979811578 1.5582722916756089 0.1191687143720701 1.0 0.327331803778814 2 Q14849 1 +Complex 1 LYR protein domain [IPR008011] 0.9007402422611084 1.543951796388621 0.1226000106803886 1.0 0.3323431581644318 2 Q9NU23 1 +GOLD domain [IPR009038] 0.6463293374944397 1.5355341936062463 0.1246526645606216 1.0 0.3349612764483005 7 Q15363,P49755,Q9Y3B3 3 +Intermediate filament head, DNA-binding domain [IPR006821] 0.7616161616161614 1.5330785372969338 0.1252565051971554 1.0 0.3356006832784844 4 P08670,P07197,Q16352 3 +Phospholipase D/Transphosphatidylase [IPR001736] 0.8977119784656848 1.5310612339595906 0.125754259568728 1.0 0.3357179335350301 2 Q8N2A8 1 +Importin-alpha, importin-beta-binding domain [IPR002652] 0.745869765291504 1.4642024687297417 0.1431386359039252 1.0 0.3586523855607053 4 O00505 1 +Phospholipid/glycerol acyltransferase [IPR002123] 0.6236140108223177 1.420988604055591 0.1553200724436201 1.0 0.374235765100376 7 Q9NUQ2,Q8NF37,Q92604,Q99943,O15228 5 +Alpha galactosidase A, C-terminal beta-sandwich domain [IPR035373] 0.8691117092866761 1.409287592086054 0.1587501462533906 1.0 0.3790986835087275 2 P06280 1 +MHC class I-like antigen recognition-like [IPR011161] 0.7321323440019449 1.4039450062793386 0.1603352262448272 1.0 0.3805416025538845 4 P10321,P04439 2 +Immunoglobulin C1-set [IPR003597] 0.7321323440019449 1.4039450062793386 0.1603352262448272 1.0 0.3805416025538845 4 P10321,P04439 2 +Fatty acid desaturase domain [IPR005804] 0.8660834454912552 1.3963986850447416 0.1625944708648612 1.0 0.3834597925599039 2 O15121 1 +Tim44-like domain [IPR007379] 0.8596904441453572 1.3691976957501717 0.1709374861137644 1.0 0.3989084518651052 2 Q9BRJ2 1 +FAD-binding domain, PCMH-type [IPR016166] 0.8519515477792816 1.3362917150068694 0.1814539434437594 1.0 0.4120586767628229 2 Q15392 1 +FAD linked oxidase, N-terminal [IPR006094] 0.8519515477792816 1.3362917150068694 0.1814539434437594 1.0 0.4120586767628229 2 Q15392 1 +CNNM, transmembrane domain [IPR002550] 0.8512786002691802 1.3334316864477052 0.1823901797637956 1.0 0.4130353007046918 2 Q8NE01 1 +Ion transporter-like, CBS domain [IPR044751] 0.8512786002691802 1.3334316864477052 0.1823901797637956 1.0 0.4130353007046918 2 Q8NE01 1 +Glycosyl transferase, family 1 [IPR001296] 0.8502691790040435 1.3291421005136623 0.1838010928201616 1.0 0.4150784826787415 2 Q9BT22 1 +Peptidase M16, N-terminal [IPR011765] 0.6048187738468211 1.325560743805443 0.1849852364676016 1.0 0.4162167820521038 7 P22695,Q5JRX3,Q10713 3 +Peptidase M16, C-terminal [IPR007863] 0.6048187738468211 1.325560743805443 0.1849852364676016 1.0 0.4162167820521038 7 P22695,Q5JRX3,Q10713 3 +Acyl-CoA oxidase, C-terminal [IPR002655] 0.8452220726783359 1.3077030381033248 0.1909740524841048 1.0 0.4235751836831872 2 Q15067 1 +Endoplasmic reticulum vesicle transporter, N-terminal [IPR039542] 0.8371467025572106 1.2734360996603584 0.2028633341858396 1.0 0.4329637681664651 2 Q9Y282 1 +Endoplasmic reticulum vesicle transporter, C-terminal [IPR012936] 0.8371467025572106 1.2734360996603584 0.2028633341858396 1.0 0.4329637681664651 2 Q9Y282 1 +Zinc finger, CHHC-type [IPR012996] 0.8381016492763373 1.2544426813384102 0.2096811472303752 1.0 0.4388781680728934 3 P52597,P55795 2 +FAD dependent oxidoreductase [IPR006076] 0.6927247021640028 1.230550694503809 0.2184909556562928 1.0 0.4484197777864751 4 Q96CU9 1 +Major facilitator superfamily domain [IPR020846] 0.8308260417565543 1.2254515992645607 0.2204051157044049 1.0 0.4507533193353243 3 P53985 1 +Acyltransferase, C-terminal domain [IPR032098] 0.8246971736204664 1.2207158336573636 0.2221936306330301 1.0 0.4532750064913814 2 Q9NUQ2 1 +3-hydroxyacyl-CoA dehydrogenase, C-terminal [IPR006108] 0.8172947510094216 1.1894455800593078 0.2342643737015519 1.0 0.4666226092932459 2 P40939 1 +3-hydroxyacyl-CoA dehydrogenase, NAD binding [IPR006176] 0.8172947510094216 1.1894455800593078 0.2342643737015519 1.0 0.4666226092932459 2 P40939 1 +CBS domain [IPR000644] 0.577755758011253 1.1873758445425355 0.2350794036171448 1.0 0.4674029012499852 7 Q8NE01,P51798,Q6P4Q7 3 +Sec23, C-terminal [IPR037550] 0.8129205921938178 1.1709994794216054 0.241598986401476 1.0 0.4741812670619961 2 Q15437 1 +Cation-transporting P-type ATPase, C-terminal [IPR006068] 0.816896667788616 1.1700319526867626 0.2419881104557864 1.0 0.4741812670619961 3 P05023,P16615 2 +Cation-transporting P-type ATPase, N-terminal [IPR004014] 0.816896667788616 1.1700319526867626 0.2419881104557864 1.0 0.4741812670619961 3 P05023,P16615 2 +MHC class I, alpha chain, C-terminal [IPR010579] 0.8165600807808747 1.168694488037818 0.242526743511501 1.0 0.4741812670619961 3 P10321,P04439 2 +MHC class I alpha chain, alpha1 alpha2 domains [IPR001039] 0.8165600807808747 1.168694488037818 0.242526743511501 1.0 0.4741812670619961 3 P10321,P04439 2 +Prolyl 4-hydroxylase alpha subunit, Fe(2+) 2OG dioxygenase domain [IPR044862] 0.8075370121130623 1.1483326660600215 0.2508312588161132 1.0 0.4794981825334084 2 P13674 1 +Heterogeneous nuclear ribonucleoprotein Q acidic domain [IPR041337] 0.8058546433378206 1.141258025861391 0.2537625637383953 1.0 0.4826812401177869 2 O60506 1 +N-acetylgalactosaminyltransferase [IPR045885] 0.8088224793503009 1.1379745906204537 0.2551310925742593 1.0 0.4835050611297012 3 Q8N4A0 1 +ATPase family AAA domain-containing protein 3, N-terminal [IPR021911] 0.8041722745625886 1.134187761433091 0.2567157965830979 1.0 0.4835050611297012 2 Q9NVI7 1 +Pancreatic trypsin inhibitor Kunitz domain [IPR002223] 0.7974427994616407 1.1059530069738566 0.2687468599125022 1.0 0.4950280760465053 2 Q06481 1 +Amyloidogenic glycoprotein, heparin-binding [IPR015849] 0.7974427994616407 1.1059530069738566 0.2687468599125022 1.0 0.4950280760465053 2 Q06481 1 +Beta-amyloid precursor protein C-terminal [IPR019543] 0.7974427994616407 1.1059530069738566 0.2687468599125022 1.0 0.4950280760465053 2 Q06481 1 +Amyloidogenic glycoprotein, extracellular [IPR008154] 0.7974427994616407 1.1059530069738566 0.2687468599125022 1.0 0.4950280760465053 2 Q06481 1 +Amyloidogenic glycoprotein, copper-binding [IPR011178] 0.7974427994616407 1.1059530069738566 0.2687468599125022 1.0 0.4950280760465053 2 Q06481 1 +Amyloidogenic glycoprotein, E2 domain [IPR024329] 0.7974427994616407 1.1059530069738566 0.2687468599125022 1.0 0.4950280760465053 2 Q06481 1 +Marvel domain [IPR008253] 0.7923956931359464 1.0848292244749849 0.277997299316242 1.0 0.5041017694267855 2 O43760 1 +Aminopeptidase N-like , N-terminal domain [IPR045357] 0.6048575482337888 1.0804491708006578 0.279942209790841 1.0 0.5050099702048481 5 Q9NZ08,Q9UIQ6 2 +Peptidase M1, membrane alanine aminopeptidase [IPR014782] 0.6048575482337888 1.0804491708006578 0.279942209790841 1.0 0.5050099702048481 5 Q9NZ08,Q9UIQ6 2 +CARG-binding factor, N-terminal [IPR012956] 0.7833109017496633 1.046932135272905 0.2951308793802991 1.0 0.5179723731641585 2 Q99729 1 +VPS13, repeated coiled region [IPR031642] 0.7823014804845208 1.0427320914852862 0.2970723904912085 1.0 0.5179723731641585 2 Q5THJ4 1 +Vacuolar protein sorting-associated protein 13, SHR-binding domain [IPR009543] 0.7823014804845208 1.0427320914852862 0.2970723904912085 1.0 0.5179723731641585 2 Q5THJ4 1 +Vacuolar protein sorting-associated protein 13-like, N-terminal domain [IPR026854] 0.7823014804845208 1.0427320914852862 0.2970723904912085 1.0 0.5179723731641585 2 Q5THJ4 1 +Vacuolar protein sorting-associated protein 13, C-terminal [IPR031645] 0.7823014804845208 1.0427320914852862 0.2970723904912085 1.0 0.5179723731641585 2 Q5THJ4 1 +Vacuolar protein sorting-associated protein 13, second N-terminal domain [IPR031646] 0.7823014804845208 1.0427320914852862 0.2970723904912085 1.0 0.5179723731641585 2 Q5THJ4 1 +Ribosomal S6 kinase, N-terminal catalytic domain [IPR041906] 0.7678331090174999 0.982796385323028 0.3257076612438938 1.0 0.5490646323135043 2 P51812 1 +Alpha-L-fucosidase, C-terminal [IPR031919] 0.766487213997317 0.9772481114045464 0.3284463347099189 1.0 0.5514863958045355 2 Q9BTY2 1 +Tudor domain [IPR002999] 0.5804568724451862 0.9655927137075002 0.3342480227337581 1.0 0.5557351723580046 5 Q14739,Q16637 2 +Arginyl-tRNA synthetase, catalytic core domain [IPR035684] 0.7627860026918003 0.9620162463087508 0.3360414431162457 1.0 0.557337027607432 2 P54136 1 +DALR anticodon binding [IPR008909] 0.7627860026918003 0.9620162463087508 0.3360414431162457 1.0 0.557337027607432 2 P54136 1 +ERAP1-like C-terminal domain [IPR024571] 0.7616963985190037 0.952478344603334 0.3408544434135288 1.0 0.5622720198627483 3 Q9NZ08,Q9UIQ6 2 +Far upstream element-binding protein, C-terminal [IPR015096] 0.7594212651413197 0.948203223789606 0.3430260063012171 1.0 0.5650926402593403 2 Q92945 1 +Dynamin, N-terminal [IPR045063] 0.5308046959466577 0.9468553410485296 0.3437124972698524 1.0 0.565462495508467 7 O95140,O60313,Q8IWA4,Q9H223 4 +Dynamin-type guanine nucleotide-binding (G) domain [IPR030381] 0.5308046959466577 0.9468553410485296 0.3437124972698524 1.0 0.565462495508467 7 O95140,O60313,Q8IWA4,Q9H223 4 +NIPSNAP [IPR012577] 0.7520188425302867 0.9179359620688776 0.3586523928776359 1.0 0.57421913522855 2 Q9BPW8 1 +v-SNARE, coiled-coil homology domain [IPR042855] 0.7492426792325779 0.9041233175177557 0.3659300154408085 1.0 0.5809316976647855 3 O15498,O75396 2 +Longin domain [IPR010908] 0.7492426792325779 0.9041233175177557 0.3659300154408085 1.0 0.5809316976647855 3 O15498,O75396 2 +SUN coiled coil domain 2 [IPR040994] 0.7328398384925991 0.8403902743940481 0.4006896003689979 1.0 0.6119077615117323 2 Q9UH99 1 +Pumilio homology domain [IPR033133] 0.7325033647375563 0.8390422667190572 0.4014455916950064 1.0 0.612623184446764 2 Q15397 1 +Fzo/mitofusin HR2 domain [IPR006884] 0.7257738896366117 0.8121810232061119 0.4166877668669684 1.0 0.6238848032356812 2 Q8IWA4 1 +Armadillo repeat-containing domain [IPR006911] 0.7247644683714651 0.8081685493751875 0.4189935601880115 1.0 0.6244631765565615 2 Q8N2F6 1 +Acyl transferase [IPR014043] 0.7217362045760531 0.7961582689716801 0.4259400496618835 1.0 0.6314964141299793 2 P49327 1 +ELMO domain [IPR006816] 0.7176985195154792 0.7802096455576378 0.4352674857770089 1.0 0.6345624818870923 2 Q8IZ81 1 +NOPS [IPR012975] 0.6984180410636138 0.7114514744048855 0.4768045109936851 1.0 0.6702388449903034 3 P23246,Q8WXF1 2 +Diacylglycerol kinase, catalytic domain [IPR001206] 0.6982245886620673 0.7107361920720677 0.4772477276660196 1.0 0.6702388449903034 3 Q53H12 1 +Peptidase M3A/M3B catalytic domain [IPR001567] 0.6980814540558554 0.7102070621628236 0.477575742112627 1.0 0.6702388449903034 3 Q9BYT8,Q99797 2 +Prolyl 4-hydroxylase, alpha subunit [IPR006620] 0.5718657315155099 0.7066075829040979 0.4798103753070337 1.0 0.6708028547981831 4 P13674 1 +Oxoglutarate/iron-dependent dioxygenase [IPR005123] 0.5718657315155099 0.7066075829040979 0.4798103753070337 1.0 0.6708028547981831 4 P13674 1 +Lamin tail domain [IPR001322] 0.6960619320094211 0.7027509758824798 0.4822109536365162 1.0 0.6733898542511076 3 P02545,P20700 2 +Thioredoxin domain [IPR013766] 0.343150419698946 0.6939051392372991 0.4877417004370152 1.0 0.6745363340070787 24 Q9Y320,Q96JJ7,Q9H3N1,Q9H1E5,O43819 5 +TGS [IPR004095] 0.4860293154209202 0.6867909716079672 0.4922144599609155 1.0 0.6769331449350119 6 Q9NTK5 1 +AMP-dependent synthetase/ligase [IPR000873] 0.5069046817110128 0.6274141130566464 0.5303878189903968 1.0 0.7047590250752009 5 Q6P1M0,O95573,Q4G176,P33121 4 +Sterile alpha motif domain [IPR001660] 0.460215778826692 0.6233969590008881 0.5330236958516268 1.0 0.7060833373618952 8 Q13586,Q9Y3Z3,Q15375,Q6SZW1,Q9Y6Y8,Q8IXK0,Q5PRF9 7 +SCP2 sterol-binding domain [IPR003033] 0.6699448818296404 0.6080837771859164 0.5431319112069035 1.0 0.7091130232717332 3 Q6YN16 1 +RNA recognition motif domain, eukaryote [IPR003954] 0.3843921853009149 0.5698201614650558 0.5687996795832224 1.0 0.7302811130190298 13 Q14498,P38159,Q14011,Q9UHX1,Q96I25 5 +SET domain [IPR001214] 0.6587007741501005 0.5684580972672573 0.5697239507890282 1.0 0.7309665783708286 3 Q03164,Q9H7B4 2 +Serine hydroxymethyltransferase-like domain [IPR039429] 0.6554508748317676 0.5461297157331619 0.5849767747024133 1.0 0.7392259315167654 2 P34897 1 +Rhodanese-like domain [IPR001763] 0.5306397306397213 0.538879705295435 0.589969861573322 1.0 0.7426434099061657 4 Q99956,P25325,Q8NCN5 3 +ABC transporter-like, ATP-binding domain [IPR003439] 0.4249277868990854 0.5315284938451899 0.595052601385774 1.0 0.7466369903600075 9 P08183,O75027,Q03518,P33527 4 +Oxidoreductase FAD/NAD(P)-binding [IPR001433] 0.6455738808481818 0.5231892913676068 0.6008425327678621 1.0 0.7485528525803051 3 Q9UHQ9,P16435 2 +Flavoprotein pyridine nucleotide cytochrome reductase [IPR001709] 0.6455738808481818 0.5231892913676068 0.6008425327678621 1.0 0.7485528525803051 3 Q9UHQ9,P16435 2 +FAD-binding domain, ferredoxin reductase-type [IPR017927] 0.6455738808481818 0.5231892913676068 0.6008425327678621 1.0 0.7485528525803051 3 Q9UHQ9,P16435 2 +Histone-binding protein RBBP4, N-terminal [IPR022052] 0.6477119784656826 0.5189387341725535 0.6038034654834106 1.0 0.7495284539745746 2 Q16576 1 +Flavoprotein pyridine nucleotide cytochrome reductase-like, FAD-binding domain [IPR008333] 0.6453566621803539 0.5107636847925139 0.6095165408628616 1.0 0.7522249047779115 2 Q9UHQ9 1 +EH domain-containing protein, N-terminal [IPR031692] 0.6436742934051185 0.5049538746941012 0.6135912330976503 1.0 0.7530793217588518 2 Q9H223 1 +Domain of unknown function DUF5600 [IPR040990] 0.6436742934051185 0.5049538746941012 0.6135912330976503 1.0 0.7530793217588518 2 Q9H223 1 +FCP1 homology domain [IPR004274] 0.6329087782423239 0.4806293772764776 0.6307799324655741 1.0 0.7639402960475203 3 Q05D32 1 +Methyltransferase type 11 [IPR013216] 0.4691781669532393 0.4642732919043372 0.6424519566012892 1.0 0.773204439435282 5 Q9H8H3 1 +AMP-binding enzyme, C-terminal domain [IPR025110] 0.6228220673902762 0.4475908469815222 0.6544485101014554 1.0 0.7788478136744593 3 Q4G176 1 +Synaptotagmin-like mitochondrial-lipid-binding domain [IPR031468] 0.6248317631224818 0.4416539779446988 0.658739617439895 1.0 0.7795055674136925 2 Q9BSJ8 1 +Extended synaptotagmin, C-terminal C2 domain [IPR037752] 0.6248317631224818 0.4416539779446988 0.658739617439895 1.0 0.7795055674136925 2 Q9BSJ8 1 +Extended synaptotagmin, C2A domain [IPR037733] 0.6248317631224818 0.4416539779446988 0.658739617439895 1.0 0.7795055674136925 2 Q9BSJ8 1 +Synaptotagmin, SMP domain [IPR039010] 0.6248317631224818 0.4416539779446988 0.658739617439895 1.0 0.7795055674136925 2 Q9BSJ8 1 +Extended synaptotagmin, C2B domain [IPR037749] 0.6248317631224818 0.4416539779446988 0.658739617439895 1.0 0.7795055674136925 2 Q9BSJ8 1 +Zinc finger C2H2 AKAP95-type [IPR034736] 0.6183103332211268 0.4330749798011465 0.6649602989223153 1.0 0.7803560938455552 3 Q5BKZ1,O43823 2 +Glycosyltransferase 2-like [IPR001173] 0.4871682834485495 0.3753470298794235 0.7074023937956306 1.0 0.7961057930414717 4 Q8N4A0 1 +Guanylate kinase/L-type calcium channel beta subunit [IPR008145] 0.435490044909119 0.3292289997219874 0.7419826050320513 1.0 0.8170820589826637 5 Q9NZW5 1 +Guanylate kinase-like domain [IPR008144] 0.435490044909119 0.3292289997219874 0.7419826050320513 1.0 0.8170820589826637 5 Q9NZW5 1 +Chromo domain subgroup [IPR017984] 0.5693966675804736 0.2876071315805838 0.7736474852342303 1.0 0.8415293822522659 3 P83916 1 +Chromo shadow domain [IPR008251] 0.5693966675804736 0.2876071315805838 0.7736474852342303 1.0 0.8415293822522659 3 P83916 1 +Heterogeneous nuclear ribonucleoprotein U, SPRY domain [IPR035778] 0.5673283765571027 0.281988520198852 0.7779523128149297 1.0 0.8437870012277128 3 Q1KMD3 1 +Dehydrogenase, E1 component [IPR001017] 0.566285329744289 0.2692705574161455 0.7877214874708427 1.0 0.8492503628959072 2 Q02218 1 +FAD/NAD(P)-binding domain [IPR023753] 0.417732390589455 0.2634438816706322 0.7922084720429627 1.0 0.8511202735486042 5 O95831 1 +Sorting nexin Vps5-like, C-terminal [IPR015404] 0.4525252525252374 0.2590014778197521 0.7956341002560068 1.0 0.8531372218251005 4 O60749,Q9UNH7,Q9Y5X3 3 +CTP synthase, N-terminal [IPR017456] 0.5605652759084883 0.2546819258224595 0.7989687771251219 1.0 0.8548407195814242 2 Q9NRF8 1 +CTP synthase GATase domain [IPR033828] 0.5605652759084883 0.2546819258224595 0.7989687771251219 1.0 0.8548407195814242 2 Q9NRF8 1 +Cyclic nucleotide-binding domain [IPR000595] 0.4080184270577206 0.229323615027008 0.8186174003540181 1.0 0.8720519565128966 5 Q8IY17 1 +MoaB/Mog domain [IPR001453] 0.5464333781965091 0.220527840106663 0.8254600927471742 1.0 0.8766501128592725 2 Q9NQX3 1 +Threonyl/alanyl tRNA synthetase, SAD [IPR012947] 0.4353427075623025 0.2070490925378464 0.8359715187911885 1.0 0.8859126744592335 4 Q9BW92 1 +Nucleoporin, Nup133/Nup155-like, C-terminal [IPR007187] 0.5336473755047194 0.1920035369099728 0.8477394349196046 1.0 0.8972183902651069 2 O75694 1 +PABP, RNA recognition motif 2 [IPR045305] 0.5312920592193924 0.1869997633174304 0.8516608185174752 1.0 0.9005899281774425 2 Q13310 1 +Heat shock protein DnaJ, cysteine-rich domain [IPR001305] 0.5260854930999512 0.1802914832522764 0.8569237414977733 1.0 0.9049824500373378 3 O60884,Q96EY1 2 +CS domain [IPR007052] 0.3646801221729071 0.1793236511849759 0.8576835768872342 1.0 0.9053943062612976 8 Q9P035 1 +EF-hand, Ca insensitive [IPR014837] 0.5213732749915748 0.1699931673315601 0.8650155101233463 1.0 0.910386057085964 3 O43707,P12814 2 +SKP1 component, POZ domain [IPR016073] 0.5121130551817075 0.1491925787403026 0.8814016757643057 1.0 0.9236606602187588 2 Q15369 1 +Nucleotidyl transferase domain [IPR005835] 0.5111036339165591 0.1473481544206262 0.8828572255151168 1.0 0.9247901104240503 2 Q9NR50 1 +Brix domain [IPR007109] 0.3809363422027604 0.142101535098117 0.8869998056499557 1.0 0.9287320462921692 5 Q9NQ55,Q96G21,Q9H7B2,Q9H9Y2 4 +Glycosyl hydrolase, family 13, catalytic domain [IPR006047] 0.5047106325706648 0.1360042731446492 0.8918179028750053 1.0 0.9317841341178033 2 P08195 1 +VHS domain [IPR002014] 0.4973082099596343 0.1235949736360821 0.9016359724293026 1.0 0.9368441682966608 2 O14964 1 +RuvB-like, AAA-lid domain [IPR041048] 0.4962987886944955 0.1219628429528349 0.902928445557639 1.0 0.9373913633270144 2 Q9Y230 1 +TIP49, P-loop domain [IPR010339] 0.4962987886944955 0.1219628429528349 0.902928445557639 1.0 0.9373913633270144 2 Q9Y230 1 +Clp ATPase, C-terminal [IPR019489] 0.4858681022880216 0.1059335427659474 0.915635080513528 1.0 0.9437788114093124 2 Q9H078 1 +Ribosomal protein S7 domain [IPR023798] 0.4791386271870929 0.0963914941038583 0.9232096473897082 1.0 0.949986219760406 2 Q9Y2R9 1 +Potassium channel tetramerisation-type BTB domain [IPR003131] 0.4761103633916705 0.0922988404793911 0.9264606096024146 1.0 0.9529309127339122 2 Q9NXV2 1 +EB1, C-terminal [IPR004953] 0.4680349932705308 0.0819850881222955 0.9346585714876544 1.0 0.9603135672058266 2 Q15691 1 +PTBP1, RNA recognition motif 2-like [IPR021790] 0.4735779198922841 0.0817883187982123 0.93481504520077 1.0 0.9603135672058266 3 Q8WVV9,P14866 2 +Zinc finger, C3HC4 RING-type [IPR018957] 0.3800821248663487 0.0707724130317079 0.9435788879658042 1.0 0.9671931656992232 4 Q9H000 1 +Malic enzyme, NAD-binding [IPR012302] 0.4576043068640729 0.0699220455081227 0.9442557062934394 1.0 0.9671931656992232 2 P48163 1 +Malic enzyme, N-terminal domain [IPR012301] 0.4576043068640729 0.0699220455081227 0.9442557062934394 1.0 0.9671931656992232 2 P48163 1 +Pyrroline-5-carboxylate reductase, dimerisation domain [IPR029036] 0.4516997643890905 0.0513039684128228 0.9590833059348356 1.0 0.9794893337206833 3 Q53H96,Q96C36 2 +Pyrroline-5-carboxylate reductase, catalytic, N-terminal [IPR028939] 0.4516997643890905 0.0513039684128228 0.9590833059348356 1.0 0.9794893337206833 3 Q53H96,Q96C36 2 +Zinc finger, ZZ-type [IPR000433] 0.4071332436069987 0.0293958424822943 0.9765488885919072 1.0 0.9931830823734892 2 Q13501 1 +JAB1/MPN/MOV34 metalloenzyme domain [IPR000555] 0.3223196223870553 0.0270549591646554 0.978415898976824 1.0 0.9946686547737814 8 O15372,Q7L5N1,O00303,O95630,Q92905,O00487,P51665 7 +Man1/Src1, C-terminal [IPR018996] 0.3997308209959614 0.0255749385201855 0.9795963756940338 1.0 0.995409805731866 2 Q9Y2U8 1 +Glycerol-3-phosphate acyltransferase-like, C-terminal domain [IPR045520] 0.3977119784656772 0.0246115524323411 0.980364804583141 1.0 0.995409805731866 2 O15228 1 +GPAT/DHAPAT, acyltransferase domain [IPR041728] 0.3977119784656772 0.0246115524323411 0.980364804583141 1.0 0.995409805731866 2 O15228 1 +Sec23/Sec24 beta-sandwich [IPR012990] 0.3180634617448405 0.0189420547208772 0.9848873307349746 1.0 0.996694578602405 6 Q15437 1 +Sec23/Sec24, helical domain [IPR006900] 0.3180634617448405 0.0189420547208772 0.9848873307349746 1.0 0.996694578602405 6 Q15437 1 +Zinc finger, Sec23/Sec24-type [IPR006895] 0.3180634617448405 0.0189420547208772 0.9848873307349746 1.0 0.996694578602405 6 Q15437 1 +Sec23/Sec24, trunk domain [IPR006896] 0.3180634617448405 0.0189420547208772 0.9848873307349746 1.0 0.996694578602405 6 Q15437 1 +Methylglyoxal synthase-like domain [IPR011607] 0.3660834454912477 0.0133057133808552 0.9893838899734456 1.0 1.0 2 P31939 1 +cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain [IPR003117] 0.3543068640645997 0.0105985171377972 0.9915437651214324 1.0 1.0 2 P10644 1 +Class II aldolase/adducin N-terminal [IPR001303] 0.3384925975773863 0.0079177189397194 0.993682640307458 1.0 1.0 2 Q9UEY8 1 diff --git a/interpro_domain/selections.json b/interpro_domain/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..862191b77ea2831f62dd840f7bf72e5788eac598 --- /dev/null +++ b/interpro_domain/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["1-acyl-sn-glycerol-3-phosphate acyltransferase [IPR004552]", "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, SH3 domain [IPR035724]", "116kDa U5 small nuclear ribonucleoprotein component, C-terminal [IPR035655]", "116kDa U5 small nuclear ribonucleoprotein component, N-terminal [IPR031950]", "14-3-3 domain [IPR023410]", "18S rRNA (guanine(1575)-N(7))-methyltransferase Bud23, C-terminal [IPR022238]", "2-oxoacid dehydrogenase acyltransferase, catalytic domain [IPR001078]", "2-oxoglutarate dehydrogenase E1 component, N-terminal domain [IPR032106]", "26S proteasome non-ATPase regulatory subunit RPN1, C-terminal [IPR041433]", "26S proteasome regulatory subunit RPN2, C-terminal [IPR040623]", "26S proteasome regulatory subunit RPN5, C-terminal domain [IPR040896]", "26S proteasome regulatory subunit Rpn6, N-terminal [IPR040773]", "26S proteasome regulatory subunit Rpn7, N-terminal [IPR045135]", "26S proteasome regulatory subunit, C-terminal [IPR013586]", "2Fe-2S ferredoxin-type iron-sulfur binding domain [IPR001041]", "3'-5' exonuclease domain [IPR002562]", "3-beta hydroxysteroid dehydrogenase/isomerase [IPR002225]", "3-hydroxyacyl-CoA dehydrogenase, C-terminal [IPR006108]", "3-hydroxyacyl-CoA dehydrogenase, NAD binding [IPR006176]", "3-hydroxyisobutyrate dehydrogenase, NAD-binding domain [IPR029154]", "3-oxo-5-alpha-steroid 4-dehydrogenase, C-terminal [IPR001104]", "3-oxoacid CoA-transferase, subunit A [IPR012792]", "3-oxoacid CoA-transferase, subunit B [IPR012791]", "4'-phosphopantetheinyl transferase domain [IPR008278]", "40S ribosomal protein S11, N-terminal [IPR032440]", "40S ribosomal protein S4, C-terminal domain [IPR032277]", "40S ribosomal protein SA, C-terminal domain [IPR032281]", "4Fe-4S ferredoxin-type, iron-sulphur binding domain [IPR017896]", "5'-AMP-activated protein kinase catalytic subunit alpha-2, C-terminal [IPR039148]", "6-phosphogluconate dehydrogenase, C-terminal [IPR006114]", "6-phosphogluconate dehydrogenase, NADP-binding [IPR006115]", "6-phosphogluconolactonase, DevB-type [IPR005900]", "60S ribosomal protein L10P, insertion domain [IPR040637]", "60S ribosomal protein L4, C-terminal domain [IPR025755]", "6S proteasome subunit Rpn6, C-terminal helix domain [IPR040780]", "A kinase-anchoring protein AKAP5 and AKAP12, calmodulin (CaM)-binding motif [IPR001573]", "AAA ATPase, AAA+ lid domain [IPR041569]", "AAA+ ATPase domain [IPR003593]", "AAR2, C-terminal [IPR033648]", "AAR2, N-terminal [IPR033647]", "AARP2CN [IPR012948]", "AATF leucine zipper-containing domain [IPR025160]", "ABC transporter type 1, transmembrane domain [IPR011527]", "ABC transporter-like, ATP-binding domain [IPR003439]", "ABC-transporter extension domain [IPR032781]", "ABC1 atypical kinase-like domain [IPR004147]", "ADAR1, first double-stranded RNA binding domain [IPR044456]", "ADAR1, third double-stranded RNA binding domain [IPR044457]", "ADCK3-like domain [IPR034646]", "ADNP, zinc finger domain [IPR045762]", "AGC-kinase, C-terminal [IPR000961]", "AIMP2, lysyl-tRNA synthetase binding domain [IPR031889]", "AIMP2, thioredoxin-like domain [IPR041503]", "ALG11 mannosyltransferase, N-terminal [IPR031814]", "ALIX V-shaped domain [IPR025304]", "AMP-binding enzyme, C-terminal domain [IPR025110]", "AMP-dependent synthetase/ligase [IPR000873]", "AMPK, C-terminal adenylate sensor domain [IPR032270]", "AP complex, mu/sigma subunit [IPR022775]", "AP-2 complex subunit mu, N-terminal [IPR043532]", "AP-3 complex subunit beta 1, serine-rich domain [IPR029394]", "AP-3 complex subunit beta, C-terminal domain [IPR029390]", "AP-3 complex subunit delta domain, metazoa [IPR010474]", "AP180 N-terminal homology (ANTH) domain [IPR011417]", "ARHGEF1-like, PH domain [IPR041020]", "ARHGEF2, PH domain [IPR037806]", "ARID DNA-binding domain [IPR001606]", "ARMET, C-terminal [IPR019345]", "ARMET, N-terminal [IPR045332]", "ATP synthase, F1 complex, alpha subunit nucleotide-binding domain [IPR033732]", "ATP synthase, alpha subunit, C-terminal [IPR000793]", "ATP-citrate lyase/succinyl-CoA ligase [IPR005811]", "ATP-citrate synthase, citrate-binding domain [IPR032263]", "ATP-cone domain [IPR005144]", "ATP-dependent DNA helicase RecQ, zinc-binding domain [IPR032284]", "ATP-dependent RNA helicase Ski2, C-terminal [IPR012961]", "ATP-dependent RNA helicase eIF4A, DEAD-box helicase domain [IPR044728]", "ATP-dependent helicase, C-terminal [IPR006555]", "ATP-grasp fold [IPR011761]", "ATP-grasp fold, succinyl-CoA synthetase-type [IPR013650]", "ATP:guanido phosphotransferase, N-terminal [IPR022413]", "ATP:guanido phosphotransferase, catalytic domain [IPR022414]", "ATPase family AAA domain-containing protein 3, N-terminal [IPR021911]", "ATPase, AAA-type, core [IPR003959]", "ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain [IPR004100]", "ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domain [IPR000194]", "ATPase, V1 complex, subunit H, C-terminal [IPR011987]", "ATPase, dynein-related, AAA domain [IPR011704]", "ATPsynthase alpha/beta subunit, N-terminal extension [IPR031686]", "AWS domain [IPR006560]", "Abl Interactor 1, SH3 domain [IPR035725]", "Abl-interactor, homeo-domain homologous domain [IPR012849]", "Abscisic acid G-protein coupled receptor-like domain [IPR025969]", "Acetyl-CoA carboxylase [IPR034733]", "Acetyl-CoA carboxylase, central domain [IPR013537]", "Acetyl-coA carboxylase zinc finger domain [IPR041010]", "Acetyl-coenzyme A carboxyltransferase, C-terminal [IPR011763]", "Acetyl-coenzyme A carboxyltransferase, N-terminal [IPR011762]", "Acid ceramidase, N-terminal [IPR029130]", "Acinus, RNA recognition motif [IPR034257]", "Aconitase A, swivel domain [IPR044137]", "Aconitase A/isopropylmalate dehydratase small subunit, swivel domain [IPR000573]", "Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain [IPR001030]", "Actin-depolymerising factor homology domain [IPR002108]", "Activating signal cointegrator 1 complex subunit 2, CUE domain [IPR041800]", "Activator of Hsp90 ATPase, N-terminal [IPR015310]", "Acyl transferase [IPR014043]", "Acyl-CoA dehydrogenase family member 10/11, N-terminal [IPR041726]", "Acyl-CoA dehydrogenase/oxidase C-terminal [IPR009075]", "Acyl-CoA dehydrogenase/oxidase, N-terminal [IPR013786]", "Acyl-CoA oxidase, C-terminal [IPR002655]", "Acyl-CoA oxidase/dehydrogenase, central domain [IPR006091]", "Acyl-CoA-binding protein, ACBP [IPR000582]", "Acyl-coenzyme A oxidase, N-terminal [IPR029320]", "Acylamino-acid-releasing enzyme, N-terminal domain [IPR045550]", "Acylglycerol kinase, C-terminal [IPR045579]", "Acyltransferase, C-terminal domain [IPR032098]", "Adenosine deaminase/editase [IPR002466]", "Adenylate cyclase-associated CAP, C-terminal [IPR013912]", "Adenylate cyclase-associated CAP, N-terminal [IPR013992]", "Adenylate kinase, active site lid domain [IPR007862]", "Adenylosuccinate lyase C-terminal [IPR019468]", "Afadin, cargo binding domain [IPR037977]", "Agenet-like domain [IPR008395]", "Alanine dehydrogenase/pyridine nucleotide transhydrogenase, N-terminal [IPR007886]", "Alanine dehydrogenase/pyridine nucleotide transhydrogenase, NAD(H)-binding domain [IPR007698]", "Alanine racemase, N-terminal [IPR001608]", "Alanyl-tRNA synthetase, class IIc, N-terminal [IPR018164]", "Alanyl-tRNA synthetase, class IIc, core domain [IPR018165]", "Alcohol dehydrogenase, N-terminal [IPR013154]", "Alcohol dehydrogenase-like, C-terminal [IPR013149]", "Aldehyde dehydrogenase domain [IPR015590]", "Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant [IPR000866]", "Alpha Spectrin, SH3 domain [IPR035825]", "Alpha crystallin/Hsp20 domain [IPR002068]", "Alpha galactosidase A, C-terminal beta-sandwich domain [IPR035373]", "Alpha-2-macroglobulin RAP, C-terminal [IPR010483]", "Alpha-2-macroglobulin RAP, domain 2 [IPR038001]", "Alpha-2-macroglobulin RAP, domain 3 [IPR037999]", "Alpha-2-macroglobulin receptor-associated protein, domain 1 [IPR009066]", "Alpha-D-phosphohexomutase, C-terminal [IPR005843]", "Alpha-D-phosphohexomutase, alpha/beta/alpha domain I [IPR005844]", "Alpha-D-phosphohexomutase, alpha/beta/alpha domain II [IPR005845]", "Alpha-D-phosphohexomutase, alpha/beta/alpha domain III [IPR005846]", "Alpha-L-fucosidase, C-terminal [IPR031919]", "Alpha-N-acetylglucosaminidase, C-terminal [IPR024732]", "Alpha-N-acetylglucosaminidase, N-terminal [IPR024240]", "Alpha-N-acetylglucosaminidase, tim-barrel domain [IPR024733]", "Alpha-amylase/branching enzyme, C-terminal all beta [IPR006048]", "Alpha-dystroglycan N-terminal domain 2 [IPR041631]", "Alpha-glycerophosphate oxidase, C-terminal [IPR031656]", "Alpha-ketoglutarate-dependent dioxygenase AlkB-like [IPR027450]", "Alpha-ketoglutarate-dependent dioxygenase FTO, C-terminal [IPR024366]", "Alpha-ketoglutarate-dependent dioxygenase FTO, catalytic domain [IPR024367]", "Alpha/beta hydrolase fold-1 [IPR000073]", "Amidase signature domain [IPR023631]", "Amidohydrolase-related [IPR006680]", "Amidophosphoribosyltransferase, N-terminal [IPR035584]", "Amine oxidase [IPR002937]", "Amino acid permease/ SLC12A domain [IPR004841]", "Aminoacyl-tRNA synthetase, class I, anticodon-binding [IPR045462]", "Aminoacyl-tRNA synthetase, class II (D/K/N) [IPR004364]", "Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) [IPR002314]", "Aminoacyl-tRNA synthetase, class II [IPR006195]", "Aminoacyl-tRNA synthetase, class Ia [IPR002300]", "Aminoglycoside phosphotransferase [IPR002575]", "Aminomethyltransferase, folate-binding domain [IPR006222]", "Aminopeptidase N-like , N-terminal domain [IPR045357]", "Aminopeptidase P [IPR033740]", "Aminopeptidase P, N-terminal [IPR007865]", "Aminotransferase class V domain [IPR000192]", "Aminotransferase, class I/classII [IPR004839]", "Amyloidogenic glycoprotein, E2 domain [IPR024329]", "Amyloidogenic glycoprotein, amyloid-beta peptide [IPR013803]", "Amyloidogenic glycoprotein, copper-binding [IPR011178]", "Amyloidogenic glycoprotein, extracellular [IPR008154]", "Amyloidogenic glycoprotein, heparin-binding [IPR015849]", "Anaphase-promoting complex subunit 1, C-terminal [IPR041221]", "Anaphase-promoting complex subunit 2, C-terminal [IPR014786]", "Anaphase-promoting complex subunit 4, WD40 domain [IPR024977]", "Anaphase-promoting complex subunit 5 domain [IPR026000]", "Ancestral coatomer element 1, Sec16/Sec31 [IPR024298]", "Angiomotin, C-terminal [IPR024646]", "Anion-transporting ATPase-like domain [IPR025723]", "Ankyrin repeat and LEM domain-containing protein 2, LEM domain [IPR035006]", "Anoctamin, dimerisation domain [IPR032394]", "Anticodon-binding [IPR004154]", "Anticodon-binding domain [IPR019181]", "Antifreeze-like/N-acetylneuraminic acid synthase C-terminal [IPR006190]", "ApaG domain [IPR007474]", "Apoptosis-antagonizing transcription factor, C-terminal [IPR012617]", "Archaeal primase DnaG/twinkle, TOPRIM domain [IPR034154]", "Arf GTPase activating protein [IPR001164]", "Arfaptin homology (AH) domain [IPR010504]", "Arginyl tRNA synthetase N-terminal domain [IPR005148]", "Arginyl-tRNA synthetase, catalytic core domain [IPR035684]", "Ariadne domain [IPR045840]", "Armadillo repeat-containing domain [IPR006911]", "Aromatic amino acid beta-eliminating lyase/threonine aldolase [IPR001597]", "Asparagine synthase [IPR001962]", "Asparagine synthase, N-terminal domain [IPR033738]", "Aspartate/glutamate/uridylate kinase [IPR001048]", "Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding domain [IPR006131]", "Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding [IPR006132]", "Aspartic peptidase, DDI1-type [IPR019103]", "Aspartyl beta-hydroxylase/Triadin domain [IPR007943]", "Aspartyl/asparaginy/proline hydroxylase [IPR007803]", "Ataxin 2, SM domain [IPR025852]", "Ataxin-10 domain [IPR019156]", "Ataxin-2, C-terminal [IPR009818]", "Aurora kinase A [IPR030611]", "Aurora-A binding [IPR015128]", "Autophagy-related, C-terminal [IPR015412]", "B(0)AT2, solute-binding domain [IPR042934]", "B-block binding subunit of TFIIIC [IPR007309]", "B-box, C-terminal [IPR003649]", "B-box-type zinc finger [IPR000315]", "B3/B4 tRNA-binding domain [IPR005146]", "B30.2/SPRY domain [IPR001870]", "BAG domain [IPR003103]", "BAP29/BAP31, transmembrane domain [IPR040463]", "BAR domain [IPR004148]", "BAT2, N-terminal [IPR009738]", "BCS1, N-terminal [IPR014851]", "BEACH domain [IPR000409]", "BEN domain [IPR018379]", "BING4, C-terminal domain [IPR012952]", "BMP-2-inducible protein kinase, C-terminal [IPR028182]", "BOP1, N-terminal domain [IPR012953]", "BP28, C-terminal domain [IPR012954]", "BRAP2, RNA recognition motif [IPR034932]", "BRCA1-associated 2 [IPR011422]", "BRCT domain [IPR001357]", "BRICHOS domain [IPR007084]", "BRK domain [IPR006576]", "BRO1 domain [IPR004328]", "BSD domain [IPR005607]", "BTB/Kelch-associated [IPR011705]", "BTB/POZ domain [IPR000210]", "BURAN domain [IPR045354]", "BZW1/2, W2 domain [IPR043510]", "Bacterial Ig-like, group 2 [IPR003343]", "Bacterial surface antigen (D15) [IPR000184]", "Band 3 cytoplasmic domain [IPR013769]", "Band 4.1 domain [IPR019749]", "Band 4.1, C-terminal [IPR008379]", "Band 7 domain [IPR001107]", "Band 7, C-terminal extension [IPR032435]", "Bap31/Bap29 cytoplasmic coiled-coil domain [IPR041672]", "Beta-Casp domain [IPR022712]", "Beta-adaptin appendage, C-terminal subdomain [IPR015151]", "Beta-amyloid precursor protein C-terminal [IPR019543]", "Beta-catenin-interacting ICAT domain [IPR009428]", "Beta-catenin-like protein 1, N-terminal [IPR013180]", "Beta-galactosidase jelly roll domain [IPR025300]", "Beta-hexosaminidase, eukaryotic type, N-terminal [IPR029019]", "Beta-ketoacyl synthase, C-terminal [IPR014031]", "Beta-ketoacyl synthase, N-terminal [IPR014030]", "Bicarbonate transporter, C-terminal [IPR011531]", "Bifunctional delta 1-pyrroline-5-carboxylate synthetase, glutamate-5-kinase domain [IPR041744]", "Biliverdin reductase, catalytic [IPR015249]", "Bin3-type S-adenosyl-L-methionine binding domain [IPR024160]", "Biotin carboxylase, C-terminal [IPR005482]", "Biotin carboxylase-like, N-terminal domain [IPR005481]", "Biotin carboxylation domain [IPR011764]", "Biotin/lipoyl attachment [IPR000089]", "Bms1/Tsr1-type G domain [IPR030387]", "Borealin, N-terminal [IPR018851]", "Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase, N-terminal [IPR018955]", "Brdt, bromodomain, repeat I [IPR043508]", "Brdt, bromodomain, repeat II [IPR043509]", "Brix domain [IPR007109]", "Bromo adjacent homology (BAH) domain [IPR001025]", "Bromodomain [IPR001487]", "Bromodomain adjacent to zinc finger domain protein 1A, bromodomain [IPR037325]", "Brr2, N-terminal helicase PWI domain [IPR041094]", "Butyrophylin-like, SPRY domain [IPR003879]", "C-CAP/cofactor C-like domain [IPR017901]", "C-terminal associated domain of TOPRIM [IPR031660]", "C-type lectin-like [IPR001304]", "C2 DOCK-type domain [IPR027007]", "C2 domain [IPR000008]", "C2CD5, C2 domain [IPR037785]", "C4-type zinc-finger of DNA polymerase delta [IPR025687]", "CAAX prenyl protease 1, N-terminal [IPR032456]", "CAP Gly-rich domain [IPR000938]", "CAPN2, penta-EF hand, calcium binding motif [IPR042736]", "CARG-binding factor, N-terminal [IPR012956]", "CARP motif [IPR006599]", "CASK, SH3 domain [IPR035473]", "CBS domain [IPR000644]", "CCAAT-binding factor [IPR005612]", "CCR4-NOT transcription complex subunit 1, CAF1-binding domain [IPR032191]", "CCR4-NOT transcription complex subunit 1, HEAT repeat [IPR032194]", "CCR4-NOT transcription complex subunit 1, TTP binding domain [IPR032193]", "CCR4-NOT transcription complex subunit 1, domain 4 [IPR024557]", "CCR4-Not complex component, Not1, C-terminal [IPR007196]", "CD2-associated protein, first SH3 domain [IPR035775]", "CD2-associated protein, second SH3 domain [IPR035776]", "CD2-associated protein, third SH3 domain [IPR035777]", "CD209-like, C-type lectin-like domain [IPR033989]", "CD47 immunoglobulin-like [IPR013270]", "CD47 transmembrane [IPR013147]", "CDC48, N-terminal subdomain [IPR003338]", "CDC48, domain 2 [IPR004201]", "CDH1/2, SANT-Helical linker 1 [IPR040793]", "CELF1/2, RNA recognition motif 1 [IPR034196]", "CELF1/2, RNA recognition motif 2 [IPR034198]", "CELF1/2, RNA recognition motif 3 [IPR034199]", "CENP-T/Histone H4, histone fold [IPR035425]", "CENP-V/GFA domain [IPR006913]", "CFA20 domain [IPR007714]", "CHCH [IPR010625]", "CHD subfamily II, SANT-like domain [IPR009462]", "CHD, C-terminal 2 [IPR012957]", "CHD, N-terminal [IPR012958]", "CHORD domain [IPR007051]", "CID domain [IPR006569]", "CIDE-N domain [IPR003508]", "CLASP N-terminal domain [IPR024395]", "CLU central domain [IPR033646]", "CLU domain [IPR025697]", "CNNM, transmembrane domain [IPR002550]", "COMM domain [IPR017920]", "COMMD1 N-terminal domain [IPR033776]", "COP9 signalosome complex subunit 4, helix turn helix domain [IPR041406]", "COP9 signalosome complex subunit 7, helix I [IPR041481]", "COQ9 [IPR013718]", "CP2 transcription factor [IPR007604]", "CPL domain [IPR012959]", "CPSF2, metallo-hydrolase domain [IPR035639]", "CPSF7, RNA recognition motif [IPR034773]", "CRA domain [IPR013144]", "CRAL-TRIO lipid binding domain [IPR001251]", "CRIB domain [IPR000095]", "CRK, C-terminal SH3 domain [IPR035458]", "CRK, N-terminal SH3 domain [IPR035457]", "CS domain [IPR007052]", "CSK-like, SH2 domain [IPR035027]", "CSN8/PSMD8/EIF3K [IPR033464]", "CTLH, C-terminal LisH motif [IPR006595]", "CTLH/CRA C-terminal to LisH motif domain [IPR024964]", "CTP synthase GATase domain [IPR033828]", "CTP synthase, N-terminal [IPR017456]", "CUB domain [IPR000859]", "CYRIA/CYRIB, Rac1 binding domain [IPR009828]", "Cadherin prodomain [IPR014868]", "Cadherin, cytoplasmic domain [IPR000233]", "Cadherin-like [IPR002126]", "Calcineurin-like phosphoesterase domain, ApaH type [IPR004843]", "Calcineurin-like phosphoesterase domain, lpxH-type [IPR024654]", "Calcium uniporter protein, C-terminal [IPR006769]", "Calcium/calmodulin-dependent protein kinase II, association-domain [IPR013543]", "Calcyclin-binding Protein, CS domain [IPR037893]", "Calpain subdomain III [IPR033883]", "Calponin homology domain [IPR001715]", "Caprin-1 dimerization domain [IPR041637]", "Carbamoyl-phosphate synthase large subunit, CPSase domain [IPR005483]", "Carbamoyl-phosphate synthase small subunit, GATase1 domain [IPR035686]", "Carbamoyl-phosphate synthase small subunit, N-terminal domain [IPR002474]", "Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain [IPR005479]", "Carbamoyl-phosphate synthetase, large subunit oligomerisation domain [IPR005480]", "Carboxylase, conserved domain [IPR003379]", "Carboxypeptidase D, carboxypeptidase-like domain 2 [IPR034224]", "Carboxypeptidase D, carboxypeptidase-like domain 3 [IPR033848]", "Carnitine O-palmitoyltransferase, N-terminal [IPR032476]", "Casein kinase substrate, phosphoprotein PP28 [IPR019380]", "Caspase recruitment domain [IPR031964]", "Cathepsin C [IPR039412]", "Cathepsin C exclusion [IPR014882]", "Cation-transporting P-type ATPase, C-terminal [IPR006068]", "Cation-transporting P-type ATPase, N-terminal [IPR004014]", "Cdc23 [IPR007192]", "Cdc37, C-terminal [IPR013873]", "Cdc37, Hsp90 binding [IPR013874]", "Cdc37, N-terminal domain [IPR013855]", "Cell division control protein 73, C-terminal [IPR031336]", "Cellular tumor antigen p53, transactivation domain 2 [IPR040926]", "Centrosomal CEP44 domain [IPR029157]", "Centrosomal protein of 290kDa, coiled-coil region [IPR032321]", "Chaperone DnaJ, C-terminal [IPR002939]", "Chitinase II [IPR011583]", "Choline/carnitine acyltransferase domain [IPR039551]", "Choloylglycine hydrolase/NAAA C-terminal [IPR029132]", "Chromatin assembly factor 1 subunit B, C-terminal domain [IPR029129]", "Chromatin assembly factor 1 subunit p150, C-terminal [IPR029105]", "Chromatin assembly factor 1 subunit p150, N-terminal [IPR029091]", "Chromatin target of PRMT1 protein, C-terminal [IPR025715]", "Chromo domain [IPR023780]", "Chromo domain subgroup [IPR017984]", "Chromo shadow domain [IPR008251]", "Chromo/chromo shadow domain [IPR000953]", "Chromosome passenger complex (CPC) protein INCENP N-terminal [IPR022006]", "Chromosome segregation protein Spc25, C-terminal [IPR013255]", "Circularly permuted (CP)-type guanine nucleotide-binding (G) domain [IPR030378]", "Class I myosin tail homology domain [IPR010926]", "Class I myosin, motor domain [IPR036072]", "Class II PurE [IPR033626]", "Class II aldolase/adducin N-terminal [IPR001303]", "Class VI myosin, motor domain [IPR036114]", "Classical protein kinase C beta, catalytic domain [IPR034664]", "Clathrin adaptor, alpha-adaptin, appendage, C-terminal subdomain [IPR003164]", "Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain [IPR008152]", "Clathrin, heavy chain, linker, core motif [IPR015348]", "Clathrin/coatomer adaptor, adaptin-like, N-terminal [IPR002553]", "Cleavage and polyadenylation specificity factor 2, C-terminal [IPR025069]", "Cleavage stimulation factor subunit 2, hinge domain [IPR025742]", "Cleavage/polyadenylation specificity factor, A subunit, C-terminal [IPR004871]", "Cleavage/polyadenylation specificity factor, A subunit, N-terminal [IPR018846]", "Clp ATPase, C-terminal [IPR019489]", "Clustered mitochondria protein, N-terminal [IPR028275]", "Clusterin, C-terminal [IPR016015]", "Clusterin, N-terminal [IPR016014]", "Cns1/TTC4, wheel domain [IPR044059]", "CoA-binding [IPR003781]", "Coatomer beta subunit, C-terminal [IPR011710]", "Coatomer beta subunit, appendage platform domain [IPR029446]", "Coatomer subunit gamma, C-terminal [IPR032154]", "Coatomer, WD associated region [IPR006692]", "Coatomer, alpha subunit, C-terminal [IPR010714]", "Coatomer, gamma subunit, appendage, Ig-like subdomain [IPR013040]", "Cobalamin (vitamin B12)-binding domain [IPR006158]", "Cobalamin (vitamin B12)-binding module, cap domain [IPR003759]", "Cobalamin adenosyltransferase-like [IPR016030]", "Coilin, N-terminal domain [IPR031722]", "Cold shock domain [IPR011129]", "Cold-shock (CSD) domain [IPR019844]", "Cold-shock protein, DNA-binding [IPR002059]", "Complement Clr-like EGF domain [IPR026823]", "Complex 1 LYR protein domain [IPR008011]", "Condensin complex subunit 1, C-terminal [IPR032682]", "Condensin complex subunit 1, N-terminal [IPR024324]", "Conserved oligomeric Golgi complex, subunit 4 [IPR013167]", "Cop9 signalosome subunit 5 C-terminal domain [IPR040961]", "Copine, C-terminal [IPR010734]", "Copine, C2B domain [IPR037768]", "Core histone macro-H2A, macro domain [IPR035796]", "Cortactin, SH3 domain [IPR035716]", "Cortactin-binding protein-2, N-terminal [IPR019131]", "Creatinase, N-terminal [IPR000587]", "Cro/C1-type helix-turn-helix domain [IPR001387]", "Cullin homology domain [IPR016158]", "Cullin protein, neddylation domain [IPR019559]", "Cullin, N-terminal [IPR001373]", "Cwf19-like protein, C-terminal domain-2 [IPR006767]", "Cwf19-like, C-terminal domain-1 [IPR006768]", "Cyclic nucleotide-binding domain [IPR000595]", "Cyclin, C-terminal domain [IPR004367]", "Cyclin, N-terminal [IPR006671]", "Cyclin-like [IPR013763]", "Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain [IPR002130]", "Cystatin domain [IPR000010]", "Cysteine-rich flanking region, C-terminal [IPR000483]", "Cystine knot, C-terminal [IPR006207]", "Cytidine and deoxycytidylate deaminase domain [IPR002125]", "Cytidyltransferase-like domain [IPR004821]", "Cytochrome C oxidase subunit II, transmembrane domain [IPR011759]", "Cytochrome b5-like heme/steroid binding domain [IPR001199]", "Cytochrome c oxidase assembly factor 3, mitochondrial, coiled-coil domain [IPR018628]", "Cytochrome c oxidase subunit 2, C-terminal [IPR034210]", "Cytochrome c oxidase subunit II-like C-terminal [IPR002429]", "Cytochrome c oxidase, subunit II [IPR014222]", "Cytoplasmic activation/proliferation-associated protein-1 C term [IPR022070]", "Cytoskeleton-associated protein 2, C-terminal [IPR029197]", "Cytosolic fatty-acid binding [IPR000463]", "D-3-phosphoglycerate dehydrogenase, ASB domain [IPR045626]", "D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain [IPR006140]", "D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain [IPR006139]", "DALR anticodon binding [IPR008909]", "DAZ-associated protein 1, RNA recognition motif 1 [IPR034134]", "DAZ-associated protein 1, RNA recognition motif 2 [IPR034131]", "DBC1/CARP1 catalytically inactive NUDIX hydrolase domain [IPR025954]", "DBINO domain [IPR020838]", "DBP10, C-terminal [IPR012541]", "DDE superfamily endonuclease domain [IPR004875]", "DDHD domain [IPR004177]", "DDT domain [IPR018501]", "DDX18/Has1, DEAD-box helicase domain [IPR044773]", "DDX41, DEAD-box helicase domain [IPR044113]", "DDX47/Rrp3, DEAD-box helicase domain [IPR044765]", "DDX52/Rok1, DEAD-box helicase domain [IPR044764]", "DEAD box protein 17, ATP-binding domain [IPR046330]", "DEAD/DEAH box helicase domain [IPR011545]", "DEAD2 [IPR010614]", "DEK, C-terminal [IPR014876]", "DEUBAD domain [IPR044867]", "DExH-box ATP-dependent RNA helicase, R3H domain [IPR034083]", "DFDF domain [IPR025762]", "DG-type SEA domain [IPR030398]", "DHHA1 domain [IPR003156]", "DHX15, DEXH-box helicase domain [IPR044756]", "DHX57, UBA domain [IPR042615]", "DHX8/ Prp22, DEXH-box helicase domain [IPR044762]", "DHX9, DEXH-box helicase domain [IPR044447]", "DHX9, first double-stranded RNA binding domain [IPR044445]", "DHX9, second double-stranded RNA binding domain [IPR044446]", "DJ-1/PfpI [IPR002818]", "DMAP1-binding domain [IPR010506]", "DML1/Misato, tubulin domain [IPR029209]", "DNA (cytosine-5)-methyltransferase 1, replication foci domain [IPR022702]", "DNA damage inducible protein 1 ubiquitin-like domain [IPR033882]", "DNA fragmentation factor 45kDa, middle domain [IPR015121]", "DNA helicase, DnaB-like, C-terminal [IPR007694]", "DNA ligase 3, BRCT domain [IPR031916]", "DNA ligase, ATP-dependent, C-terminal [IPR012309]", "DNA ligase, ATP-dependent, N-terminal [IPR012308]", "DNA ligase, ATP-dependent, central [IPR012310]", "DNA mismatch repair protein MutS, C-terminal [IPR000432]", "DNA mismatch repair protein MutS, clamp [IPR007861]", "DNA mismatch repair protein MutS, connector domain [IPR007860]", "DNA mismatch repair protein MutS, core [IPR007696]", "DNA mismatch repair protein MutS-like, N-terminal [IPR007695]", "DNA polymerase alpha catalytic subunit, N-terminal domain [IPR024647]", "DNA polymerase alpha catalytic subunit, catalytic domain [IPR045846]", "DNA polymerase alpha, subunit B, N-terminal [IPR013627]", "DNA polymerase alpha/delta/epsilon, subunit B [IPR007185]", "DNA polymerase delta subunit 2, C-terminal domain [IPR041863]", "DNA polymerase delta subunit, OB-fold domain [IPR040663]", "DNA polymerase epsilon, catalytic subunit A, C-terminal [IPR013697]", "DNA replication complex GINS protein SLD5, C-terminal [IPR031633]", "DNA replication factor RFC1, C-terminal [IPR013725]", "DNA topoisomerase 2, TOPRIM domain [IPR034157]", "DNA topoisomerase I, DNA binding, eukaryotic-type [IPR008336]", "DNA topoisomerase I, catalytic core, eukaryotic-type [IPR013500]", "DNA topoisomerase I, eukaryotic-type [IPR013499]", "DNA topoisomerase, type IIA, domain A [IPR002205]", "DNA topoisomerase, type IIA, subunit B, domain 2 [IPR013506]", "DNA-dependent protein kinase catalytic subunit, CC3 [IPR012582]", "DNA-dependent protein kinase catalytic subunit, CC5 [IPR045581]", "DNA-dependent protein kinase catalytic subunit, catalytic domain [IPR037706]", "DNA-directed DNA polymerase, family B, exonuclease domain [IPR006133]", "DNA-directed DNA polymerase, family B, multifunctional domain [IPR006134]", "DNA-directed RNA polymerase I subunit RPA2, domain 4 [IPR009674]", "DNA-directed RNA polymerase III subunit RPC1, C-terminal [IPR035698]", "DNA-directed RNA polymerase III subunit RPC1, N-terminal [IPR035697]", "DNA-directed RNA polymerase, N-terminal [IPR029262]", "DNA-directed RNA polymerase, RpoA/D/Rpb3-type [IPR011263]", "DNA-directed RNA polymerase, insert domain [IPR011262]", "DNA-directed RNA polymerase, subunit 2, hybrid-binding domain [IPR007120]", "DNA-repair protein Xrcc1, N-terminal [IPR002706]", "DNA/RNA non-specific endonuclease [IPR001604]", "DNA/RNA-binding domain, Est1-type [IPR018834]", "DNA/RNA-binding protein Kin17, WH-like domain [IPR019447]", "DNA2/NAM7 helicase, helicase domain [IPR041677]", "DNA2/NAM7 helicase-like, C-terminal [IPR041679]", "DOCKER domain [IPR027357]", "DSBA-like thioredoxin domain [IPR001853]", "DTHCT [IPR012542]", "DWNN domain [IPR014891]", "DZF domain [IPR006561]", "Damage-control phosphatase ARMT1-like, metal-binding domain [IPR002791]", "Daxx, N-terminal Rassf1C-interacting domain [IPR031333]", "Dbl homology (DH) domain [IPR000219]", "Death domain [IPR000488]", "Dedicator of cytokinesis C, C2 domain [IPR037808]", "Dedicator of cytokinesis C/D, N-terminal [IPR021816]", "Dehydrogenase, E1 component [IPR001017]", "Deoxycytidylate deaminase domain [IPR035105]", "Desmoplakin, SH3 domain [IPR041615]", "Desmoplakin, spectrin-like domain [IPR041573]", "Deubiquitinating enzyme MINDY-3/4, conserved domain [IPR025257]", "Diacylglycerol kinase, accessory domain [IPR000756]", "Diacylglycerol kinase, catalytic domain [IPR001206]", "Diacylglycerol/phorbol-ester binding [IPR020454]", "Diaphanous autoregulatory (DAD) domain [IPR014767]", "Dihydrofolate reductase domain [IPR001796]", "Dilute domain [IPR002710]", "Dipeptidyl peptidase 8 /9 ,N-terminal [IPR045785]", "Dipeptidylpeptidase IV, N-terminal domain [IPR002469]", "Dis3-like cold-shock domain 2 [IPR041505]", "Disks Large homologue 3, SH3 domain [IPR035763]", "Disks large homologue 1, N-terminal PEST domain [IPR019590]", "Disulphide isomerase [IPR005788]", "DnaJ domain [IPR001623]", "DnaJ homologue subfamily C, GRV2/DNAJC13, N-terminal domain [IPR045802]", "DnaJ-like protein C11, C-terminal [IPR024586]", "Dolichyldiphosphatase, PAP2 domain [IPR039667]", "Domain of unknown function DUF1087 [IPR009463]", "Domain of unknown function DUF155 [IPR003734]", "Domain of unknown function DUF1605 [IPR011709]", "Domain of unknown function DUF1731 [IPR013549]", "Domain of unknown function DUF1747 [IPR013719]", "Domain of unknown function DUF1899 [IPR015048]", "Domain of unknown function DUF3350 [IPR021785]", "Domain of unknown function DUF3385, target of rapamycin protein [IPR024585]", "Domain of unknown function DUF3456 [IPR021852]", "Domain of unknown function DUF3480 [IPR022557]", "Domain of unknown function DUF3517 [IPR021905]", "Domain of unknown function DUF382 [IPR007180]", "Domain of unknown function DUF4042 [IPR025283]", "Domain of unknown function DUF4149 [IPR025423]", "Domain of unknown function DUF4195 [IPR025243]", "Domain of unknown function DUF4208 [IPR025260]", "Domain of unknown function DUF4217 [IPR025313]", "Domain of unknown function DUF4749 [IPR031847]", "Domain of unknown function DUF5050 [IPR032485]", "Domain of unknown function DUF5600 [IPR040990]", "Domain of unknown function DUF625 [IPR006887]", "Domain of unknown function DUF775 [IPR008493]", "Double-stranded RNA-binding domain [IPR014720]", "Down-regulated-in-metastasis protein [IPR011430]", "Drebrin-like protein, SH3 domain [IPR035717]", "Dual specificity phosphatase, catalytic domain [IPR000340]", "Dual specificity protein phosphatase domain [IPR020422]", "Dullard phosphatase domain, eukaryotic [IPR011948]", "Dynamin GTPase effector [IPR003130]", "Dynamin stalk domain [IPR000375]", "Dynamin, GTPase domain [IPR001401]", "Dynamin, N-terminal [IPR045063]", "Dynamin-like GTPase OPA1, C-terminal [IPR045817]", "Dynamin-type guanine nucleotide-binding (G) domain [IPR030381]", "Dynein associated protein [IPR022157]", "Dynein heavy chain AAA lid domain [IPR041658]", "Dynein heavy chain region D6 P-loop domain [IPR004273]", "Dynein heavy chain, AAA 5 extension domain [IPR041466]", "Dynein heavy chain, AAA module D4 [IPR024317]", "Dynein heavy chain, ATP-binding dynein motor region [IPR035706]", "Dynein heavy chain, C-terminal domain [IPR041228]", "Dynein heavy chain, coiled coil stalk [IPR024743]", "Dynein heavy chain, hydrolytic ATP-binding dynein motor region [IPR035699]", "Dynein heavy chain, linker [IPR013602]", "Dynein heavy chain, tail [IPR013594]", "Dyskerin-like [IPR012960]", "Dystroglycan, C-terminal [IPR008465]", "Dystroglycan-type cadherin-like [IPR006644]", "E2 binding [IPR014929]", "E3 ligase, CCCH-type zinc finger [IPR041367]", "E3 ubiquitin ligase EDD, ubiquitin-associated domain [IPR024725]", "E3 ubiquitin ligase UBR4, C-terminal [IPR025704]", "E3 ubiquitin ligase, domain of unknown function DUF908 [IPR010309]", "E3 ubiquitin ligase, domain of unknown function DUF913 [IPR010314]", "E3 ubiquitin-protein ligase UBR4, N-terminal [IPR045841]", "EB1, C-terminal [IPR004953]", "EBP50, C-terminal [IPR015098]", "ECSIT, C-terminal domain [IPR029342]", "EF hand associated, type-1 [IPR013566]", "EF hand associated, type-2 [IPR013567]", "EF-hand domain [IPR002048]", "EF-hand domain, type 1 [IPR015153]", "EF-hand domain, type 2 [IPR015154]", "EF-hand, Ca insensitive [IPR014837]", "EFG, domain V [IPR035649]", "EGF-like calcium-binding domain [IPR001881]", "EGF-like domain [IPR000742]", "EGF-like domain, extracellular [IPR013111]", "EH domain [IPR000261]", "EH domain-containing protein, N-terminal [IPR031692]", "EIF2AK2, first double-stranded RNA binding domain [IPR044452]", "EIF2AK2, second double-stranded RNA binding domain [IPR044453]", "ELM2 domain [IPR000949]", "ELMO domain [IPR006816]", "ELMO, armadillo-like helical domain [IPR024574]", "ENTH domain [IPR013809]", "ER membrane protein complex subunit 1, C-terminal [IPR011678]", "ER membrane protein complex subunit 7, beta-sandwich domain [IPR019008]", "ERAP1-like C-terminal domain [IPR024571]", "ERCC3/RAD25/XPB helicase, C-terminal domain [IPR032438]", "ERM family, FERM domain C-lobe [IPR041789]", "ERV/ALR sulfhydryl oxidase domain [IPR017905]", "ERdj5, C-terminal thioredoxin domain [IPR035674]", "ERdj5, first thioredoxin domain [IPR035673]", "ERp29, N-terminal [IPR012883]", "EVE domain [IPR002740]", "EWS, RNA recognition motif [IPR034869]", "EXPERA domain [IPR033118]", "Electron transfer flavoprotein, alpha subunit, C-terminal [IPR014731]", "Electron transfer flavoprotein, alpha subunit, N-terminal [IPR033947]", "Electron transfer flavoprotein, alpha/beta-subunit, N-terminal [IPR014730]", "Electron transfer flavoprotein, beta subunit, N-terminal [IPR033948]", "Elongation Factor G, domain II [IPR041095]", "Elongation factor 1 beta central acidic region, eukaryote [IPR018940]", "Elongation factor 1B gamma, C-terminal [IPR001662]", "Elongation factor 4, domain IV [IPR035654]", "Elongation factor EFG, domain V-like [IPR000640]", "Elongation factor G, domain III [IPR009022]", "Elongation factor Tu (EF-Tu), GTP-binding domain [IPR041709]", "Elongation factor Tu, domain 2 [IPR033720]", "Elp3/MiaB/NifB [IPR006638]", "Emerin, LEM domain [IPR034989]", "Endonuclease/exonuclease/phosphatase [IPR005135]", "Endophilin B2, SH3 domain [IPR035640]", "Endophilin-A, SH3 domain [IPR035824]", "Endophilin-B1, BAR domain [IPR035695]", "Endoplasmic reticulum resident protein 29, C-terminal [IPR011679]", "Endoplasmic reticulum resident protein 44, TRX-like domain b [IPR041870]", "Endoplasmic reticulum resident protein 44, TRX-like domain b' [IPR041862]", "Endoplasmic reticulum vesicle transporter, C-terminal [IPR012936]", "Endoplasmic reticulum vesicle transporter, N-terminal [IPR039542]", "Enhancer of mRNA-decapping protein 4, WD40 repeat region [IPR032401]", "Enolase, C-terminal TIM barrel domain [IPR020810]", "Enolase, N-terminal [IPR020811]", "Enoyl-CoA hydratase/isomerase domain [IPR045004]", "Ephrin receptor ligand binding domain [IPR001090]", "Ephrin receptor, transmembrane domain [IPR027936]", "Ephrin type-A receptor 7, ligand binding domain [IPR034283]", "Era-type guanine nucleotide-binding (G) domain [IPR030388]", "Eukaryotic Ribosomal Protein L27, KOW domain [IPR041991]", "Eukaryotic glycogen debranching enzyme, N-terminal domain [IPR029436]", "Eukaryotic translation initiation factor 2D, SUI1 domain [IPR039759]", "Eukaryotic translation initiation factor 3 subunit E, N-terminal [IPR019010]", "Eukaryotic translation initiation factor 3 subunit G, N-terminal [IPR024675]", "Exocyst complex component EXOC2/Sec5, N-terminal domain [IPR039481]", "Exocyst component Exo84, C-terminal [IPR032403]", "Exonuclease 1-like, PIN-like domain [IPR044752]", "Exonuclease, RNase T/DNA polymerase III [IPR013520]", "Exonuclease-1, H3TH domain [IPR037315]", "Exoribonuclease, phosphorolytic domain 1 [IPR001247]", "Exoribonuclease, phosphorolytic domain 2 [IPR015847]", "Exosome complex component, N-terminal domain [IPR025721]", "Exosome complex exonuclease RRP44, S1 domain [IPR033770]", "Exosome-associated factor Rrp6, N-terminal [IPR012588]", "Exportin-1, C-terminal [IPR014877]", "Exportin-1/Importin-beta-like [IPR013598]", "Exportin-2, C-terminal [IPR005043]", "Exportin-2, central domain [IPR013713]", "Exportin-5, C-terminal domain [IPR045478]", "Exportin-T, C-terminal domain [IPR045546]", "Extended PHD (ePHD) domain [IPR034732]", "Extended synaptotagmin, C-terminal C2 domain [IPR037752]", "Extended synaptotagmin, C2A domain [IPR037733]", "Extended synaptotagmin, C2B domain [IPR037749]", "Extracellular Endonuclease, subunit A [IPR020821]", "F-BAR domain [IPR031160]", "F-box domain [IPR001810]", "FACT complex subunit POB3-like, N-terminal PH domain [IPR035417]", "FACT complex subunit Spt16 domain [IPR013953]", "FACT complex subunit Spt16, N-terminal lobe domain [IPR029148]", "FACT complex subunit Spt16, peptidase M24-like domain [IPR033825]", "FAD dependent oxidoreductase [IPR006076]", "FAD dependent oxidoreductase, central domain [IPR032503]", "FAD linked oxidase, N-terminal [IPR006094]", "FAD-binding domain, PCMH-type [IPR016166]", "FAD-binding domain, ferredoxin reductase-type [IPR017927]", "FAD-dependent oxidoreductase 2, FAD binding domain [IPR003953]", "FAD-linked oxidase, C-terminal [IPR004113]", "FAD/NAD(P)-binding domain [IPR023753]", "FAF1, UBA-like domain [IPR044541]", "FAM192A/Fyv6, N-terminal [IPR019331]", "FAM3C (ILEI) domain [IPR039475]", "FANCI helical domain 1 [IPR029310]", "FANCI helical domain 2 [IPR029312]", "FANCI solenoid 1 cap [IPR029305]", "FANCI solenoid 1 domain [IPR029308]", "FANCI solenoid 2 domain [IPR029315]", "FANCI solenoid 3 domain [IPR029313]", "FANCI solenoid 4 domain [IPR029314]", "FARP1/FARP2/FRMD7, FERM domain C-lobe [IPR041788]", "FAS-associated factor 1-like, UBX domain [IPR033043]", "FAST kinase leucine-rich [IPR010622]", "FAST kinase-like protein, subdomain 2 [IPR013579]", "FATC domain [IPR003152]", "FCH domain [IPR001060]", "FCP1 homology domain [IPR004274]", "FDF domain [IPR019050]", "FERM adjacent (FA) [IPR014847]", "FERM central domain [IPR019748]", "FERM domain [IPR000299]", "FERM, C-terminal PH-like domain [IPR018980]", "FERM, N-terminal [IPR018979]", "FF domain [IPR002713]", "FGFR1 oncogene partner (FOP), N-terminal dimerisation domain [IPR018993]", "FHOD1, N-terminal GTPase-binding domain [IPR041387]", "FIST, C-domain [IPR019494]", "FKBP-type peptidyl-prolyl cis-trans isomerase domain [IPR001179]", "FKBP12-rapamycin binding domain [IPR009076]", "FKBP3, basic tilted helix bundle domain [IPR041200]", "FY-rich, C-terminal [IPR003889]", "FY-rich, N-terminal [IPR003888]", "FYVE zinc finger [IPR000306]", "Far upstream element-binding protein, C-terminal [IPR015096]", "Fascin domain [IPR022768]", "Fatty acid desaturase domain [IPR005804]", "Fatty acid hydroxylase [IPR006694]", "Fatty acyl-CoA reductase, C-terminal [IPR033640]", "Fatty acyl-coenzyme A reductase, NAD-binding domain [IPR013120]", "Fcf2 pre-rRNA processing, C-terminal [IPR014810]", "Ferritin-like diiron domain [IPR009040]", "Ferritin/DPS protein domain [IPR008331]", "Ferrochelatase, C-terminal [IPR033644]", "Ferrochelatase, N-terminal [IPR033659]", "Ferrodoxin-fold anticodon-binding domain [IPR005121]", "Fibronectin type II domain [IPR000562]", "Fibronectin type III [IPR003961]", "First polo-box domain [IPR033701]", "Flavodoxin-like [IPR001094]", "Flavodoxin/nitric oxide synthase [IPR008254]", "Flavoprotein pyridine nucleotide cytochrome reductase [IPR001709]", "Flavoprotein pyridine nucleotide cytochrome reductase-like, FAD-binding domain [IPR008333]", "Follistatin-like, N-terminal [IPR003645]", "Forkhead-associated (FHA) domain [IPR000253]", "Formin, FH2 domain [IPR015425]", "Formin, FH3 domain [IPR010472]", "Formin, GTPase-binding domain [IPR010473]", "Formyl transferase, N-terminal [IPR002376]", "Fragile X-related 1 protein, C-terminal core [IPR022034]", "Fragile X-related 1 protein, C-terminal region 1 [IPR032172]", "Fragile X-related 1 protein, C-terminal region 3 [IPR032177]", "Fragile X-related mental retardation protein, C-terminal region 2 [IPR032196]", "Fumarase C, C-terminal [IPR018951]", "Fumarate lyase, N-terminal [IPR022761]", "Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal [IPR015939]", "Fumarylacetoacetase, N-terminal [IPR015377]", "Fumarylacetoacetase-like, C-terminal [IPR011234]", "Fxr1, tudor domain [IPR041560]", "Fzo/mitofusin HR2 domain [IPR006884]", "G-patch domain [IPR000467]", "G-patch domain and KOW motifs-containing protein, KOW 1 [IPR041993]", "G-patch domain and KOW motifs-containing protein, KOW 2 [IPR041994]", "G-protein gamma-like domain [IPR015898]", "G-protein, beta subunit [IPR001632]", "G3BP1, RNA recognition motif [IPR034374]", "G3BP2, RNA recognition motif [IPR034376]", "GAD domain [IPR029351]", "GAR domain [IPR003108]", "GB1/RHD3-type guanine nucleotide-binding (G) domain [IPR030386]", "GCC2, Rab binding domain [IPR032023]", "GCF, C-terminal [IPR022783]", "GH15-like domain [IPR011613]", "GHMP kinase N-terminal domain [IPR006204]", "GHMP kinase, C-terminal domain [IPR013750]", "GINS complex protein Sld5, alpha-helical domain [IPR038749]", "GINS subunit, domain A [IPR021151]", "GMP phosphodiesterase, delta subunit [IPR008015]", "GMP synthase, C-terminal [IPR001674]", "GMP synthase, glutamine amidotransferase [IPR004739]", "GMP synthetase ATP pyrophosphatase domain [IPR025777]", "GNAT domain [IPR000182]", "GOLD domain [IPR009038]", "GPAT/DHAPAT, acyltransferase domain [IPR041728]", "GPR domain [IPR000965]", "GRAM domain [IPR004182]", "GRASP-type PDZ domain [IPR024958]", "GRB2, C-terminal SH3 domain [IPR035643]", "GRB2, N-terminal SH3 domain [IPR035641]", "GRIP domain [IPR000237]", "GRSF-1, RNA recognition motif 1 [IPR034425]", "GRSF-1, RNA recognition motif 2 [IPR034424]", "GRSF-1, RNA recognition motif 3 [IPR034426]", "GTP binding domain [IPR006073]", "GTP binding protein 1-like, GTP-binding domain [IPR035531]", "GTP binding protein, second domain [IPR031662]", "GTP-binding protein LepA, C-terminal [IPR013842]", "GTP-binding protein TrmE, N-terminal [IPR018948]", "GTP1/OBG domain [IPR006169]", "GTPase effector domain [IPR020850]", "GUCT [IPR012562]", "GYF domain 2 [IPR025640]", "GYF domain [IPR003169]", "Galactokinase, N-terminal domain [IPR019539]", "Galactose mutarotase, N-terminal barrel [IPR031727]", "Galanin [IPR008174]", "Galanin message associated peptide (GMAP) [IPR013068]", "Gamma tubulin complex component protein, N-terminal [IPR041470]", "Gamma tubulin complex component, C-terminal [IPR040457]", "Gamma-adaptin ear (GAE) domain [IPR008153]", "Gamma-glutamyl cyclotransferase-like [IPR013024]", "Gcp-like domain [IPR000905]", "Gelsolin-like domain [IPR007123]", "Gfo/Idh/MocA-like oxidoreductase, N-terminal [IPR000683]", "GlmS/AgaS, SIS domain 1 [IPR035466]", "GlmS/FrlB, SIS domain 2 [IPR035490]", "Glucosamine/galactosamine-6-phosphate isomerase [IPR006148]", "Glucose-6-phosphate dehydrogenase, C-terminal [IPR022675]", "Glucose-6-phosphate dehydrogenase, NAD-binding [IPR022674]", "Glucosidase 2 subunit beta-like [IPR036607]", "Glucosidase II beta subunit, N-terminal [IPR028146]", "Glucosyltransferase 24, catalytic domain [IPR040497]", "Glutamate/phenylalanine/leucine/valine dehydrogenase, C-terminal [IPR006096]", "Glutamate/phenylalanine/leucine/valine dehydrogenase, dimerisation domain [IPR006097]", "Glutaminase, EF-hand domain [IPR041541]", "Glutamine amidotransferase [IPR017926]", "Glutamine amidotransferase type 2 domain [IPR017932]", "Glutamine-Leucine-Glutamine, QLQ [IPR014978]", "Glutaminyl-tRNA synthetase, class Ib, non-specific RNA-binding domain 2 [IPR007638]", "Glutaminyl-tRNA synthetase, class Ib, non-specific RNA-binding domain, N-terminal [IPR007639]", "Glutamyl-tRNA synthetase [IPR033910]", "Glutamyl/glutaminyl-tRNA synthetase, class Ib, anti-codon binding domain [IPR020059]", "Glutamyl/glutaminyl-tRNA synthetase, class Ib, catalytic domain [IPR020058]", "Glutaredoxin [IPR002109]", "Glutaredoxin, PICOT-like [IPR033658]", "Glutathione S-transferase, C-terminal [IPR004046]", "Glutathione S-transferase, C-terminal-like [IPR010987]", "Glutathione S-transferase, N-terminal [IPR004045]", "Glutathione synthase, substrate-binding domain [IPR004887]", "Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain [IPR020828]", "Glyceraldehyde 3-phosphate dehydrogenase, catalytic domain [IPR020829]", "Glycerol-3-phosphate acyltransferase-like, C-terminal domain [IPR045520]", "Glycerophosphodiester phosphodiesterase domain [IPR030395]", "Glycine cleavage T-protein, C-terminal barrel domain [IPR013977]", "Glycogen debranching enzyme, C-terminal [IPR032790]", "Glycogen debranching enzyme, central domain [IPR032788]", "Glycogen debranching enzyme, glucanotransferase domain [IPR032792]", "Glycoside hydrolase 35, catalytic domain [IPR031330]", "Glycoside hydrolase family 18, catalytic domain [IPR001223]", "Glycoside hydrolase family 20, catalytic domain [IPR015883]", "Glycoside hydrolase family 31, N-terminal domain [IPR025887]", "Glycoside hydrolase family 38, N-terminal domain [IPR000602]", "Glycoside hydrolase family 38, central domain [IPR015341]", "Glycoside hydrolase, family 13, N-terminal [IPR004193]", "Glycosyl hydrolase family 30, TIM-barrel domain [IPR033453]", "Glycosyl hydrolase family 30, beta sandwich domain [IPR033452]", "Glycosyl hydrolase family 38, C-terminal [IPR011682]", "Glycosyl hydrolase family 63, C-terminal [IPR031335]", "Glycosyl hydrolase family 63, N-terminal [IPR031631]", "Glycosyl hydrolase, family 13, catalytic domain [IPR006047]", "Glycosyl hydrolases family 38, C-terminal beta sandwich domain [IPR041147]", "Glycosyl transferase CAP10 domain [IPR006598]", "Glycosyl transferase, family 1 [IPR001296]", "Glycosyltransferase 2-like [IPR001173]", "Glycyl-tRNA synthetase-like core domain [IPR033731]", "Glyoxalase domain-containing protein 4, C-terminal [IPR043194]", "Glyoxalase/fosfomycin resistance/dioxygenase domain [IPR004360]", "Golgi pH regulator, conserved domain [IPR022535]", "Golgin subfamily A, conserved domain [IPR043976]", "Growth hormone-inducible transmembrane protein [IPR035871]", "Guanine nucleotide exchange factor, N-terminal [IPR032691]", "Guanine nucleotide-binding protein-like 3, N-terminal domain [IPR014813]", "Guanylate kinase-like domain [IPR008144]", "Guanylate kinase/L-type calcium channel beta subunit [IPR008145]", "Guanylate-binding protein, N-terminal [IPR015894]", "Guanylate-binding protein/Atlastin, C-terminal [IPR003191]", "HAD-superfamily hydrolase, subfamily IIID [IPR011943]", "HAD-superfamily hydrolase,subfamily IIIA [IPR006549]", "HAUS augmin-like complex subunit 3, N-terminal [IPR032733]", "HBS1-like protein, N-terminal [IPR015033]", "HD domain [IPR006674]", "HD/PDEase domain [IPR003607]", "HDGF-related, PWWP domain [IPR035496]", "HECT domain [IPR000569]", "HELLS, N-terminal [IPR044753]", "HELP [IPR005108]", "HHH domain 9 [IPR041692]", "HIRAN domain [IPR014905]", "HIT-like domain [IPR011146]", "HORMA domain [IPR003511]", "HR1 rho-binding domain [IPR011072]", "HRDC domain [IPR002121]", "HSPA4, nucleotide-binding domain [IPR042052]", "HSPA4L, nucleotide-binding domain [IPR042708]", "HSPH1, nucleotide-binding domain [IPR042053]", "HTH CenpB-type DNA-binding domain [IPR006600]", "HTTM [IPR011020]", "HUWE1, UBA domain [IPR041918]", "Heat shock 70kDa protein 14, nucleotide-binding domain [IPR042049]", "Heat shock chaperonin-binding [IPR006636]", "Heat shock protein DnaJ, cysteine-rich domain [IPR001305]", "Heat shock protein Hsp90, N-terminal [IPR020575]", "Heat shock protein beta-1, ACD domain [IPR037876]", "Heavy metal-associated domain, HMA [IPR006121]", "Heavy metal-associated domain, copper ion-binding [IPR006122]", "Helical and beta-bridge domain [IPR010643]", "Helicase XPB/Ssl2, N-terminal domain [IPR032830]", "Helicase domain [IPR007807]", "Helicase superfamily 1/2, ATP-binding domain [IPR014001]", "Helicase superfamily 1/2, ATP-binding domain, DinG/Rad3-type [IPR014013]", "Helicase, C-terminal [IPR001650]", "Helicase-associated domain [IPR007502]", "Helicase-like, DEXD box c2 type [IPR006554]", "Helicase/SANT-associated domain [IPR014012]", "Helicase/UvrB, N-terminal [IPR006935]", "Helix-hairpin-helix DNA-binding motif, class 1 [IPR003583]", "Helix-turn-helix DNA-binding domain of Spt6 [IPR028088]", "Hemimethylated DNA-binding domain [IPR011722]", "Hepatocyte growth factor-regulated tyrosine kinase substrate, helical domain [IPR024641]", "Heterogeneous nuclear ribonucleoprotein Q acidic domain [IPR041337]", "Heterogeneous nuclear ribonucleoprotein Q, RNA recognition motif 1 [IPR034544]", "Heterogeneous nuclear ribonucleoprotein Q, RNA recognition motif 2 [IPR034548]", "Heterogeneous nuclear ribonucleoprotein R, RNA recognition motif 2 [IPR034411]", "Heterogeneous nuclear ribonucleoprotein U, SPRY domain [IPR035778]", "Hexokinase, C-terminal [IPR022673]", "Hexokinase, N-terminal [IPR022672]", "HhH-GPD domain [IPR003265]", "High mobility group box domain 5 [IPR029215]", "High mobility group box domain [IPR009071]", "Histidine kinase domain [IPR005467]", "Histidine kinase/HSP90-like ATPase [IPR003594]", "Histone H2A, C-terminal domain [IPR032454]", "Histone H2A/H2B/H3 [IPR007125]", "Histone acetyl transferase HAT1 N-terminal [IPR019467]", "Histone acetyltransferase domain, MYST-type [IPR002717]", "Histone chaperone domain CHZ [IPR019098]", "Histone deacetylase domain [IPR023801]", "Histone deacetylase interacting domain [IPR013194]", "Histone-arginine methyltransferase CARM1, N-terminal [IPR020989]", "Histone-binding protein RBBP4, N-terminal [IPR022052]", "HnRNP M, nuclear localisation signal [IPR024666]", "Homeobox domain [IPR001356]", "Homocysteine-binding domain [IPR003726]", "Hotdog acyl-CoA thioesterase (ACOT)-type domain [IPR033120]", "HuR, RNA recognition motif 2 [IPR034996]", "Hyaluronan-mediated motility receptor, C-terminal [IPR031794]", "Hyaluronan/mRNA-binding protein [IPR006861]", "Hydroxymethylglutaryl-coenzyme A synthase, C-terminal domain [IPR013746]", "Hydroxymethylglutaryl-coenzyme A synthase, N-terminal [IPR013528]", "I/LWEQ domain [IPR002558]", "IBR domain [IPR002867]", "IF2a, S1-like domain [IPR044126]", "IGF2BP1, RNA recognition motif 1 [IPR034837]", "IGF2BP1, RNA recognition motif 2 [IPR034842]", "IGF2BP2, RNA recognition motif 1 [IPR034843]", "IGF2BP3, RNA recognition motif 2 [IPR034844]", "ILEI/PANDER domain [IPR039477]", "IMD/I-BAR domain [IPR013606]", "IMP dehydrogenase/GMP reductase [IPR001093]", "IPS1, CARD domain [IPR042144]", "IPT domain [IPR002909]", "IRG-type guanine nucleotide-binding (G) domain [IPR030385]", "IRS-type PTB domain [IPR002404]", "IRSp53, SH3 domain [IPR035594]", "ISWI, HAND domain [IPR015194]", "Ima1, N-terminal domain [IPR018617]", "Immunoglobulin C1-set [IPR003597]", "Immunoglobulin I-set [IPR013098]", "Immunoglobulin V-set domain [IPR013106]", "Immunoglobulin subtype 2 [IPR003598]", "Immunoglobulin subtype [IPR003599]", "Immunoglobulin-like domain [IPR007110]", "Importin-alpha, importin-beta-binding domain [IPR002652]", "Importin-beta, N-terminal domain [IPR001494]", "Initiation factor eIF-4 gamma, MA3 [IPR003891]", "Inner centromere protein, ARK-binding domain [IPR005635]", "Inositol polyphosphate 5-phosphatase, clathrin binding domain [IPR031995]", "Inositol polyphosphate-related phosphatase [IPR000300]", "Integrator complex subunit 11, MBL-fold [IPR041897]", "Integrator complex subunit 14, C-terminal [IPR045814]", "Integrator complex subunit 3, N-terminal [IPR019333]", "Integrin beta N-terminal [IPR033760]", "Integrin beta subunit, VWA domain [IPR002369]", "Integrin beta subunit, cytoplasmic domain [IPR014836]", "Integrin beta subunit, tail [IPR012896]", "Integrin beta, epidermal growth factor-like domain 1 [IPR040622]", "Integrin-linked protein kinase, pseudokinase domain [IPR035692]", "Intermediate filament head, DNA-binding domain [IPR006821]", "Intermediate filament, rod domain [IPR039008]", "Intracellular hyaluronan-binding protein 4, N-terminal domain [IPR032381]", "Intron-binding protein aquarius, N-terminal [IPR032174]", "Ion transporter-like, CBS domain [IPR044751]", "Iron sulphur domain-containing, mitoNEET, N-terminal [IPR019610]", "Iron-binding zinc finger, CDGSH type [IPR018967]", "Isochorismatase-like [IPR000868]", "Isoleucyl tRNA synthetase type 1, anticodon-binding domain [IPR033708]", "Isoleucyl tRNA synthetase type 2, anticodon-binding domain [IPR033709]", "Isopenicillin N synthase-like, Fe(2+) 2OG dioxygenase domain [IPR044861]", "Isopropylmalate dehydrogenase-like domain [IPR024084]", "JAB1/MPN/MOV34 metalloenzyme domain [IPR000555]", "JNK-interacting protein, leucine zipper II [IPR032486]", "JNK/Rab-associated protein-1, N-terminal [IPR019143]", "JmjC domain [IPR003347]", "Jumonji, helical domain [IPR041070]", "K Homology domain [IPR004087]", "K Homology domain, type 1 [IPR004088]", "K Homology domain, type 2 [IPR004044]", "KASH domain [IPR012315]", "KHDRBS, Qua1 domain [IPR032571]", "KMT2A, PHD domain 1 [IPR042023]", "KMT2A, PHD domain 2 [IPR042025]", "KMT2A, PHD domain 3 [IPR044133]", "KMT2A, ePHD domain [IPR041958]", "KN17, SH3-like C-terminal domain [IPR041330]", "KOW [IPR005824]", "Kin17, KOW domain [IPR041995]", "Kindlin-2, N-terminal [IPR040790]", "Kindlin/fermitin, PH domain [IPR037837]", "Kinesin motor domain [IPR001752]", "Kinesin-associated [IPR032405]", "Kinesin-associated microtubule-binding domain [IPR025901]", "Kinesin-like [IPR022164]", "Kinesin-like protein Kif23, Arf6-interacting domain [IPR032384]", "Kinetochore protein Nuf2, N-terminal [IPR005549]", "Kri1-like, C-terminal [IPR024626]", "Krr1, KH1 domain [IPR041174]", "Ku, C-terminal [IPR014893]", "Ku70/Ku80 C-terminal arm [IPR005160]", "Ku70/Ku80 beta-barrel domain [IPR006164]", "Ku70/Ku80, N-terminal alpha/beta [IPR005161]", "L1 transposable element, RRM domain [IPR043636]", "L1 transposable element, dsRBD-like domain [IPR035300]", "L1 transposable element, trimerization domain [IPR035301]", "L27 domain [IPR004172]", "L27 domain, C-terminal [IPR014775]", "LAIKA domain [IPR045353]", "LARP4, RNA recognition motif [IPR034903]", "LARP5, RNA recognition motif [IPR034900]", "LARP7, RNA recognition motif 1 [IPR034887]", "LARP7, RNA recognition motif 2 [IPR034910]", "LEM domain [IPR003887]", "LEM-like domain [IPR013146]", "LETM1, ribosome-binding domain [IPR033122]", "LETM1-like [IPR011685]", "LIS1 homology motif [IPR006594]", "LSM domain, eukaryotic/archaea-type [IPR001163]", "LSM-interacting domain [IPR008669]", "LYRM2, LYR domain [IPR045293]", "La protein, xRRM domain [IPR014886]", "La-related protein 7, La domain [IPR034946]", "La-type HTH domain [IPR006630]", "Lactate/malate dehydrogenase, C-terminal [IPR022383]", "Lactate/malate dehydrogenase, N-terminal [IPR001236]", "Lamin tail domain [IPR001322]", "Lamin-B receptor of TUDOR domain [IPR019023]", "Lamina-associated polypeptide 2 alpha, C-terminal [IPR021623]", "Laminin G domain [IPR001791]", "Large proline-rich protein BAG6 [IPR021925]", "Lasp1, SH3 domain [IPR035630]", "Legume-like lectin [IPR005052]", "Lens epithelium-derived growth factor, integrase-binding domain [IPR021567]", "Leucine zipper, homeobox-associated [IPR003106]", "Leucine-rich repeat N-terminal domain [IPR000372]", "Leukocyte surface antigen CD47, IgV [IPR037805]", "Linker histone H1/H5, domain H15 [IPR005818]", "Lipocalin/cytosolic fatty-acid binding domain [IPR000566]", "Lon, substrate-binding domain [IPR003111]", "Longin domain [IPR010908]", "Lsm14-like, N-terminal [IPR025609]", "Lsm16, N-terminal [IPR034107]", "LsmAD domain [IPR009604]", "Lunapark domain [IPR019273]", "LysM domain [IPR018392]", "Lysine-tRNA ligase, class II, N-terminal [IPR044136]", "Lysophosphatidylcholine acyltransferase LPCAT1-like [IPR045252]", "Lysyl-tRNA synthetase, class II, C-terminal [IPR018149]", "M60-like domain, N-terminal [IPR035423]", "MAGE homology domain [IPR002190]", "MAN1, RNA recognition motif [IPR034394]", "MANSC domain [IPR013980]", "MATH/TRAF domain [IPR002083]", "MCM N-terminal domain [IPR027925]", "MCM OB domain [IPR033762]", "MCM domain [IPR001208]", "MCM, AAA-lid domain [IPR041562]", "MD-2-related lipid-recognition domain [IPR003172]", "MDM2-binding protein, N-terminal domain [IPR029421]", "MDM2-binding protein, central domain [IPR029420]", "MDN2-binding protein, C-terminal domain [IPR029418]", "MEF-2, RNA recognition motif 1 [IPR034630]", "MEF-2, RNA recognition motif 3 [IPR034631]", "MENTAL domain [IPR019498]", "MHC class I alpha chain, alpha1 alpha2 domains [IPR001039]", "MHC class I, alpha chain, C-terminal [IPR010579]", "MHC class I-like antigen recognition-like [IPR011161]", "MIA2, SH3 domain [IPR035555]", "MIF4G-like, type 1 [IPR015172]", "MIF4G-like, type 2 [IPR015174]", "MIF4G-like, type 3 [IPR003890]", "MIRO domain [IPR020860]", "MIT domain [IPR007330]", "MKI67 FHA domain-interacting nucleolar phosphoprotein, FHA Ki67 binding [IPR021043]", "MMS19, C-terminal [IPR024687]", "MMS19, N-terminal [IPR029240]", "MOSC, N-terminal beta barrel [IPR005303]", "MPN domain [IPR037518]", "MPP1, SH3 domain [IPR035475]", "MPP6, SH3 domain [IPR035603]", "MRG domain [IPR026541]", "MRH domain [IPR044865]", "MRPL44, double-stranded RNA binding domain [IPR044444]", "MST4, kinase domain [IPR035056]", "MTMR14, PH-GRAM domain [IPR039803]", "MYST, zinc finger domain [IPR040706]", "Macro domain [IPR002589]", "Mad3/Bub1 homology region 1 [IPR013212]", "Major facilitator superfamily domain [IPR020846]", "Major sperm protein (MSP) domain [IPR000535]", "Malectin domain [IPR021720]", "Malic enzyme, N-terminal domain [IPR012301]", "Malic enzyme, NAD-binding [IPR012302]", "Man1/Src1, C-terminal [IPR018996]", "Manganese/iron superoxide dismutase, C-terminal [IPR019832]", "Manganese/iron superoxide dismutase, N-terminal [IPR019831]", "Mannose-1-phosphate guanyltransferase, N-terminal domain [IPR045233]", "MaoC-like dehydratase domain [IPR002539]", "Marvel domain [IPR008253]", "Matrin-3, RNA recognition motif 1 [IPR034928]", "Matrin-3, RNA recognition motif 2 [IPR034930]", "Matrin/U1-C, C2H2-type zinc finger [IPR000690]", "Matrin/U1-C-like, C2H2-type zinc finger [IPR003604]", "Mcm6, C-terminal winged-helix domain [IPR041024]", "Mediator complex, subunit Med25, NR box [IPR021406]", "Mediator complex, subunit Med25, PTOV domain [IPR021394]", "Mediator complex, subunit Med25, synapsin 1 [IPR021397]", "Mediator of RNA polymerase II transcription subunit 25, von Willebrand factor type A domain [IPR021419]", "Membrane insertase YidC/Oxa1, C-terminal [IPR028055]", "Metallo-beta-lactamase [IPR001279]", "Metastasis-associated protein MTA1, R1 domain [IPR035170]", "Metaxin, glutathione S-transferase domain [IPR033468]", "Methionine synthase, B12-binding domain [IPR033706]", "Methionine--tRNA ligase, N-terminal [IPR041598]", "Methioninyl-tRNA synthetase core domain [IPR033911]", "Methionyl-tRNA synthetase, anticodon-binding domain [IPR041872]", "Methionyl/Leucyl tRNA synthetase [IPR015413]", "Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding [IPR013155]", "Methyl-CpG DNA binding [IPR001739]", "Methyl-CpG binding protein 2/3, C-terminal domain [IPR025884]", "Methyl-CpG-binding domain protein 2/3, p55-binding region [IPR032343]", "Methylglyoxal synthase-like domain [IPR011607]", "Methylmalonyl-CoA mutase, C-terminal [IPR006159]", "Methylmalonyl-CoA mutase, alpha chain, catalytic [IPR006098]", "Methylmalonyl-CoA mutase, alpha/beta chain, catalytic [IPR006099]", "Methylthiotransferase, N-terminal [IPR013848]", "Methyltransferase domain 25 [IPR041698]", "Methyltransferase domain [IPR025714]", "Methyltransferase type 11 [IPR013216]", "Methyltransferase type 12 [IPR013217]", "Mib-herc2 [IPR010606]", "Midasin AAA lid domain 5 [IPR041190]", "Midasin, AAA lid domain 7 [IPR040848]", "Minichromosome loss protein Mcl1, middle region [IPR022100]", "Misato Segment II tubulin-like domain [IPR019605]", "Mitochondria fission protein Fis1, cytosolic domain [IPR033745]", "Mitochondrial apoptosis-inducing factor, C-terminal domain [IPR029324]", "Mitochondrial cytochrome c oxidase subunit VIc/VIIs [IPR034884]", "Mitochondrial degradasome RNA helicase subunit, C-terminal domain [IPR022192]", "Mitochondrial outer membrane transport complex Sam37/metaxin, N-terminal domain [IPR019564]", "Mitochondrial ribosomal protein L46 NUDIX [IPR033650]", "MnmE, helical domain [IPR025867]", "MoaB/Mog domain [IPR001453]", "Modifier of rudimentary, Modr [IPR009851]", "MoeA, C-terminal, domain IV [IPR005111]", "MoeA, N-terminal and linker domain [IPR005110]", "Molybdenum cofactor sulfurase, C-terminal [IPR005302]", "Molybdopterin oxidoreductase [IPR006656]", "Molybdopterin oxidoreductase, 4Fe-4S domain [IPR006963]", "Mot1, ATP-binding domain [IPR044078]", "Mot1, central domain [IPR022707]", "Mre11 nuclease, N-terminal metallophosphatase domain [IPR041796]", "Mre11, DNA-binding [IPR007281]", "Mst1 SARAH domain [IPR024205]", "Mu homology domain [IPR028565]", "Mu2, C-terminal domain [IPR043512]", "Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal [IPR031717]", "Multiple myeloma tumor-associated protein 2-like, N-terminal [IPR019315]", "Multiprotein bridging factor 1, N-terminal [IPR013729]", "Myb domain [IPR017930]", "Myosin VI, cargo binding domain [IPR032412]", "Myosin head, motor domain [IPR001609]", "Myosin phosphatase-RhoA interacting protein, PH domain [IPR039597]", "Myosin tail [IPR002928]", "Myosin, N-terminal, SH3-like [IPR004009]", "Myotubularin-like phosphatase domain [IPR010569]", "Myristoyl-CoA:protein N-myristoyltransferase, C-terminal [IPR022677]", "Myristoyl-CoA:protein N-myristoyltransferase, N-terminal [IPR022676]", "N-acetylgalactosaminyltransferase [IPR045885]", "N-acetylneuraminic acid synthase, N-terminal [IPR013132]", "N-end aminoacyl transferase, N-terminal [IPR007471]", "N-end rule aminoacyl transferase, C-terminal [IPR007472]", "NACHT nucleoside triphosphatase [IPR007111]", "NAD(P) binding domain of glutamate dehydrogenase [IPR033922]", "NAD(P) transhydrogenase, alpha subunit, C-terminal [IPR024605]", "NAD-dependent epimerase/dehydratase [IPR001509]", "NAD/GMP synthase [IPR022310]", "NADH-quinone oxidoreductase, chain G, C-terminal [IPR015405]", "NADH-quinone oxidoreductase, subunit D [IPR001135]", "NADH-ubiquinone oxidoreductase 51kDa subunit, FMN-binding domain [IPR011538]", "NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain [IPR019575]", "NADH:ubiquinone oxidoreductase, 30kDa subunit [IPR001268]", "NADH:ubiquinone oxidoreductase, subunit G, iron-sulphur binding [IPR019574]", "NADH:ubiquinone oxidoreductase-like, 20kDa subunit [IPR006137]", "NADP transhydrogenase beta-like domain [IPR034300]", "NADP-dependent oxidoreductase domain [IPR023210]", "NDUFB9, LYR domain [IPR045292]", "NECAP, PHear domain [IPR012466]", "NEDD8 ultimate buster 1, ubiquitin-like domain [IPR041207]", "NEMO, Zinc finger [IPR034735]", "NET domain [IPR027353]", "NF-kappa-B essential modulator NEMO, CC2-LZ domain [IPR032419]", "NF-kappa-B essential modulator NEMO, N-terminal [IPR021063]", "NF-kappaB-repression factor, R3H domain [IPR034071]", "NFACT protein, C-terminal [IPR021846]", "NFACT, RNA-binding domain [IPR008532]", "NGN domain [IPR005100]", "NGN domain, eukaryotic [IPR039385]", "NIF system FeS cluster assembly, NifU, C-terminal [IPR001075]", "NIPSNAP [IPR012577]", "NLE [IPR012972]", "NOG, C-terminal [IPR012973]", "NOG1, N-terminal helical domain [IPR041623]", "NOP5, N-terminal [IPR012974]", "NOPS [IPR012975]", "NOSIC [IPR012976]", "NOT2/NOT3/NOT5, C-terminal [IPR007282]", "NP60, PWWP domain [IPR035501]", "NPL4, zinc-binding putative [IPR007716]", "NSD, Cys-His rich domain [IPR041306]", "NUC153 [IPR012580]", "NUC205 domain [IPR012584]", "NUDIX hydrolase [IPR020476]", "NUDIX hydrolase domain [IPR000086]", "NVL2, nucleolin binding domain [IPR031996]", "Nas2, N-terminal [IPR040815]", "Nascent polypeptide-associated complex NAC domain [IPR002715]", "Negative elongation factor E, RNA recognition motif [IPR034637]", "Neurobeachin-like, DUF1088 [IPR010508]", "Neurobeachin/BDCP, DUF4704 [IPR031570]", "Nicastrin, small lobe [IPR041084]", "Nicotinamide phosphoribosyltransferase, N-terminal domain [IPR041529]", "Nicotinate/nicotinamide phosphoribosyltransferase [IPR041525]", "Niemann-Pick C1, N-terminal [IPR032190]", "Nin one binding (NOB1) Zn-ribbon-like [IPR014881]", "Nitric oxide synthase-interacting protein, zinc-finger [IPR031790]", "Non-canonical purine NTP phosphatase/PRRC1 [IPR026533]", "Nop domain [IPR002687]", "Nop2p [IPR011023]", "Npc2 like, ML domain [IPR033916]", "Nrap protein domain 1 [IPR035082]", "Nrap protein, domain 2 [IPR035367]", "Nrap protein, domain 3 [IPR035368]", "Nrap protein, domain 4 [IPR035369]", "Nrap protein, domain 5 [IPR035370]", "Nrap protein, domain 6 [IPR035371]", "Nuclear RNA export factor Tap, RNA-binding domain [IPR015245]", "Nuclear condensin complex subunit 3, C-terminal domain [IPR025977]", "Nuclear migration protein nudC [IPR032572]", "Nuclear pore complex protein Nup214, phenylalanine-glycine (FG) domain [IPR041553]", "Nuclear pore complex, NUP2/50/61 [IPR015007]", "Nuclear pore localisation protein NPL4, C-terminal [IPR007717]", "Nuclear pore localisation protein Npl4, ubiquitin-like domain [IPR024682]", "Nuclear protein 96 [IPR021967]", "Nuclear transport factor 2 domain [IPR002075]", "Nuclear transport factor 2, eukaryote [IPR018222]", "Nuclear-interacting partner of ALK/Rsm1-like [IPR013909]", "Nucleolar GTP-binding protein 1, Rossman-fold domain [IPR010674]", "Nucleolar GTP-binding protein 2, N-terminal domain [IPR012971]", "Nucleolar complex-associated protein 3, N-terminal [IPR011501]", "Nucleolar pre-ribosomal-associated protein 1, C-terminal domain [IPR032436]", "Nucleolar pre-ribosomal-associated protein 1, N-terminal [IPR021714]", "Nucleolar protein 7, C-terminal [IPR012579]", "Nucleolar protein 8, RNA recognition motif [IPR034138]", "Nucleolin, RNA recognition motif 1 [IPR034230]", "Nucleolin, RNA recognition motif 2 [IPR034233]", "Nucleolin, RNA recognition motif 3 [IPR034234]", "Nucleolin, RNA recognition motif 4 [IPR034235]", "Nucleophosmin, C-terminal [IPR032569]", "Nucleoplasmin core domain [IPR024057]", "Nucleoporin Nup153, N-terminal [IPR013913]", "Nucleoporin Nup188, N-terminal [IPR018864]", "Nucleoporin Nup54, alpha-helical domain [IPR025712]", "Nucleoporin, NSP1-like, C-terminal [IPR007758]", "Nucleoporin, Nup133/Nup155-like, C-terminal [IPR007187]", "Nucleoporin, Nup133/Nup155-like, N-terminal [IPR014908]", "Nucleoprotein TPR/MLP1 [IPR012929]", "Nucleoredoxin, redox inactive TRX-like domain b' [IPR041861]", "Nucleoside diphosphate kinase-like domain [IPR034907]", "Nucleoside phosphorylase domain [IPR000845]", "Nucleotide exchange factor Fes1 [IPR013918]", "Nucleotidyl transferase domain [IPR005835]", "NudC N-terminal domain [IPR025934]", "NudC domain-containing protein 2, p23 domain [IPR037902]", "NuoE domain [IPR042128]", "Nup358/RanBP2 E3 ligase domain [IPR022011]", "Nup54, C-terminal interacting domain [IPR040985]", "NusG, N-terminal [IPR006645]", "O-GlcNAc transferase, C-terminal [IPR029489]", "OB-fold nucleic acid binding domain, AA-tRNA synthetase-type [IPR004365]", "OBG-type guanine nucleotide-binding (G) domain [IPR031167]", "OCRE domain [IPR041591]", "OCRL1, PH domain [IPR037787]", "OCRL1/INPP5B, INPP5c domain [IPR037793]", "OTU domain [IPR003323]", "Occludin homology domain [IPR010844]", "Orotate phosphoribosyl transferase domain [IPR004467]", "Orotidine 5'-phosphate decarboxylase domain [IPR001754]", "Ovarian carcinoma immunoreactive antigen domain [IPR009764]", "Oxidoreductase FAD/NAD(P)-binding [IPR001433]", "Oxidoreductase, N-terminal domain [IPR041694]", "Oxoglutarate/iron-dependent dioxygenase [IPR005123]", "P-type ATPase, haloacid dehalogenase domain [IPR044492]", "P-type trefoil domain [IPR000519]", "PA domain [IPR003137]", "PABP, RNA recognition motif 2 [IPR045305]", "PACSIN1/PACSIN2, SH3 domain [IPR035743]", "PACSIN2, F-BAR domain [IPR037453]", "PADR1 domain [IPR012982]", "PAP/25A-associated [IPR002058]", "PARN, R3H domain [IPR034042]", "PB1 domain [IPR000270]", "PCNA-associated factor, histone-like domain [IPR031444]", "PD-(D/E)XK endonuclease-like domain, AddAB-type [IPR038726]", "PDIP3, RNA recognition motif [IPR034784]", "PDZ domain 6 [IPR041489]", "PDZ domain [IPR001478]", "PDZ-associated domain of NMDA receptors [IPR019583]", "PET domain [IPR010442]", "PET testin [IPR033724]", "PH-BEACH domain [IPR023362]", "PIK-related kinase [IPR014009]", "PIK-related kinase, FAT [IPR003151]", "PIN domain [IPR002716]", "PITH domain [IPR010400]", "PKD domain [IPR000601]", "PKD/Chitinase domain [IPR022409]", "PLAA family ubiquitin binding domain [IPR015155]", "PLC-gamma, C-terminal SH2 domain [IPR035023]", "PLC-gamma, N-terminal SH2 domain [IPR035024]", "PLD-like domain [IPR032803]", "PNK, FHA domain [IPR041388]", "POLO box domain [IPR000959]", "POPLD domain [IPR012590]", "POTRA domain [IPR034746]", "PP2B, metallophosphatase domain [IPR041751]", "PP5, C-terminal metallophosphatase domain [IPR041753]", "PPIL4-like, cyclophilin domain [IPR035538]", "PPM-type phosphatase domain [IPR001932]", "PPP domain [IPR013235]", "PRKAA2, UBA-like autoinhibitory domain [IPR028783]", "PRKRA, first double-stranded RNA binding domain [IPR044465]", "PRKRA, second double-stranded RNA binding domain [IPR044466]", "PRKRA, third double-stranded RNA binding domain [IPR044467]", "PRMT5 arginine-N-methyltransferase [IPR035075]", "PRMT5, TIM barrel domain [IPR035247]", "PRMT5, oligomerisation domain [IPR035248]", "PRO8NT domain [IPR012591]", "PROCN domain [IPR012592]", "PROCT domain [IPR012984]", "PRP1 splicing factor, N-terminal [IPR010491]", "PRP8 domain IV core [IPR021983]", "PSF, NOPS domain [IPR034526]", "PSF, RNA recognition motif 1 [IPR034525]", "PSI domain [IPR016201]", "PSP, proline-rich [IPR006568]", "PSP1, RNA recognition motif 1 [IPR034522]", "PSP1, RNA recognition motif 2 [IPR034523]", "PTB/PI domain [IPR006020]", "PTBP1, RNA recognition motif 1 [IPR035000]", "PTBP1, RNA recognition motif 2-like [IPR021790]", "PTBP1, RNA recognition motif 3 [IPR035001]", "PUA domain [IPR002478]", "PUF60, RNA recognition motif 1 [IPR034209]", "PUF60, RNA recognition motif 2 [IPR034211]", "PUF60, RNA recognition motif 3 [IPR034212]", "PUL domain [IPR013535]", "PWI domain [IPR002483]", "PWWP domain [IPR000313]", "Paf1 complex subunit Cdc73, N-terminal domain [IPR032041]", "Palladin, C-terminal immunoglobulin-like domain [IPR033017]", "Palmitoyltransferase, DHHC domain [IPR001594]", "Pancreatic trypsin inhibitor Kunitz domain [IPR002223]", "Patatin-like phospholipase domain [IPR002641]", "Pentacotripeptide-repeat region of PRORP [IPR033443]", "Pep3/Vps18/deep orange [IPR007810]", "Peptidase C12, C-terminal domain [IPR041507]", "Peptidase C12, ubiquitin carboxyl-terminal hydrolase [IPR001578]", "Peptidase C19, ubiquitin carboxyl-terminal hydrolase [IPR001394]", "Peptidase C19, ubiquitin-specific peptidase, DUSP domain [IPR006615]", "Peptidase C1A, papain C-terminal [IPR000668]", "Peptidase C1A, propeptide [IPR012599]", "Peptidase C2, calpain, catalytic domain [IPR001300]", "Peptidase C2, calpain, domain III [IPR022683]", "Peptidase C2, calpain, large subunit, domain III [IPR022682]", "Peptidase M1, leukotriene A4 hydrolase/aminopeptidase C-terminal [IPR015211]", "Peptidase M1, membrane alanine aminopeptidase [IPR014782]", "Peptidase M13, C-terminal domain [IPR018497]", "Peptidase M13, N-terminal domain [IPR008753]", "Peptidase M14, carboxypeptidase A [IPR000834]", "Peptidase M16, C-terminal [IPR007863]", "Peptidase M16, N-terminal [IPR011765]", "Peptidase M16, middle/third domain [IPR032632]", "Peptidase M16C associated [IPR013578]", "Peptidase M17, leucyl aminopeptidase, C-terminal [IPR000819]", "Peptidase M17, leucyl aminopeptidase, N-terminal [IPR008283]", "Peptidase M20, dimerisation domain [IPR011650]", "Peptidase M24 [IPR000994]", "Peptidase M24, C-terminal domain [IPR032416]", "Peptidase M28 [IPR007484]", "Peptidase M3A/M3B catalytic domain [IPR001567]", "Peptidase M41 [IPR000642]", "Peptidase M41, FtsH extracellular [IPR011546]", "Peptidase M48 [IPR001915]", "Peptidase S16, Lon proteolytic domain [IPR008269]", "Peptidase S24/S26A/S26B/S26C [IPR015927]", "Peptidase S26 [IPR019533]", "Peptidase S53, activation domain [IPR015366]", "Peptidase S54, rhomboid domain [IPR022764]", "Peptidase S59, nucleoporin [IPR007230]", "Peptidase S8/S53 domain [IPR000209]", "Peptidase S8A, tripeptidyl peptidase II [IPR022229]", "Peptidase S9, prolyl oligopeptidase, catalytic domain [IPR001375]", "Peptidase S9A, N-terminal domain [IPR023302]", "Peptidase family M60 domain [IPR031161]", "Peptide chain release factor class I [IPR000352]", "Peptidyl-prolyl cis-trans isomerase, PpiC-type [IPR000297]", "Pericentriolar material 1 protein, C-terminal [IPR031446]", "Peripheral subunit-binding domain [IPR004167]", "Peroxiredoxin, C-terminal [IPR019479]", "Peroxisome membrane anchor protein Pex14p, N-terminal [IPR006785]", "PheRS DNA binding domain 2 [IPR040586]", "PheRS, DNA binding domain 1 [IPR040724]", "PheRS, DNA binding domain 3 [IPR040725]", "Phenylacetic acid degradation-related domain [IPR003736]", "Phenylalanine--tRNA ligase beta subunit, B1 domain [IPR040659]", "Phenylalanyl tRNA synthetase beta chain, core domain [IPR041616]", "Phenylalanyl-tRNA synthetase [IPR002319]", "Phosducin, thioredoxin-like domain [IPR024253]", "Phosphatidic acid phosphatase type 2/haloperoxidase [IPR000326]", "Phosphatidylinositol 3-/4-kinase, catalytic domain [IPR000403]", "Phosphatidylinositol-4-phosphate 5-kinase, core [IPR002498]", "Phosphatidylinositol-specific phospholipase C, X domain [IPR000909]", "Phosphoadenosine phosphosulphate reductase [IPR002500]", "Phosphoenolpyruvate carboxykinase, C-terminal P-loop domain [IPR035077]", "Phosphoenolpyruvate carboxykinase, GTP-utilising, N-terminal [IPR035078]", "Phosphofructokinase domain [IPR000023]", "Phosphoglucose isomerase, SIS domain 1 [IPR035476]", "Phosphoglucose isomerase, SIS domain 2 [IPR035482]", "Phosphoinositide 3-kinase, accessory (PIK) domain [IPR001263]", "Phospholipase C, phosphatidylinositol-specific, Y domain [IPR001711]", "Phospholipase D-like domain [IPR025202]", "Phospholipase D/Transphosphatidylase [IPR001736]", "Phospholipase/carboxylesterase/thioesterase [IPR003140]", "Phospholipid/glycerol acyltransferase [IPR002123]", "Phosphopantetheine binding ACP domain [IPR009081]", "Phosphoribosylformylglycinamidine synthase, N-terminal [IPR040707]", "Phosphoribosylformylglycinamidine synthase, linker domain [IPR041609]", "Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain [IPR020561]", "Phosphoribosylglycinamide synthetase, C-domain [IPR020560]", "Phosphoribosylglycinamide synthetase, N-terminal [IPR020562]", "Phosphoribosyltransferase domain [IPR000836]", "Phosphoribulokinase/uridine kinase [IPR006083]", "Phosphorylase b kinase regulatory subunit alpha/beta, C-terminal domain [IPR045583]", "Phosphorylated adapter RNA export protein, RNA-binding domain [IPR019385]", "Phosphotyrosine protein phosphatase I [IPR023485]", "Phox homology [IPR001683]", "Phox-associated domain [IPR003114]", "Pinin/SDK [IPR006787]", "Pinin/SDK/MemA protein [IPR006786]", "Pirin, C-terminal domain [IPR008778]", "Pirin, N-terminal domain [IPR003829]", "Plasma membrane calcium transporting P-type ATPase, C-terminal [IPR022141]", "Pleckstrin homology domain 8 [IPR041680]", "Pleckstrin homology domain 9 [IPR041681]", "Pleckstrin homology domain [IPR001849]", "Pleckstrin homology domain, spectrin-type [IPR001605]", "Plectin/S10, N-terminal [IPR005326]", "Polo-like kinase 1, catalytic domain [IPR033702]", "Poly(A) polymerase, RNA-binding domain [IPR007010]", "Poly(A) polymerase, central domain [IPR007012]", "Poly(A)-specific ribonuclease, RNA-binding [IPR014789]", "Poly(ADP-ribose) polymerase, catalytic domain [IPR012317]", "Poly(ADP-ribose) polymerase, regulatory domain [IPR004102]", "Polyadenylate-binding protein/Hyperplastic disc protein [IPR002004]", "Polyamine biosynthesis domain [IPR030374]", "Polycomb group protein, RNA binding region [IPR033763]", "Polycomb protein, VEFS-Box [IPR019135]", "Polyketide synthase, C-terminal extension [IPR032821]", "Polyketide synthase, beta-ketoacyl synthase domain [IPR020841]", "Polyketide synthase, dehydratase domain [IPR020807]", "Polyketide synthase, enoylreductase domain [IPR020843]", "Polyketide synthase, ketoreductase domain [IPR013968]", "Polyketide synthase, phosphopantetheine-binding domain [IPR020806]", "Polymerase, nucleotidyl transferase domain [IPR002934]", "Polynucleotide 3'-phosphatase [IPR006551]", "Polypyrimidine tract-binding protein1/2/3, RNA recognition motif 2 [IPR034798]", "Polyribonucleotide 5'-hydroxyl-kinase Clp1, P-loop domain [IPR032319]", "Polyribonucleotide nucleotidyltransferase, RNA-binding domain [IPR015848]", "Polysaccharide biosynthesis domain [IPR021148]", "Pop1, N-terminal [IPR009723]", "Porphobilinogen deaminase, C-terminal [IPR022418]", "Porphobilinogen deaminase, N-terminal [IPR022417]", "Possible tRNA binding domain [IPR027992]", "Post-SET domain [IPR003616]", "Potassium channel tetramerisation-type BTB domain [IPR003131]", "Potentiating neddylation domain [IPR005176]", "Pre-PUA domain [IPR041366]", "Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term [IPR021718]", "Pre-mRNA polyadenylation factor Fip1 domain [IPR007854]", "Pre-mRNA processing factor 4 (PRP4)-like [IPR014906]", "Pre-mRNA splicing factor component Cdc5p/Cef1, C-terminal [IPR021786]", "Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding [IPR019581]", "Pre-mRNA-processing-splicing factor 8, U6-snRNA-binding [IPR019580]", "Pre-mRNA-splicing factor 19 [IPR013915]", "Pre-rRNA-processing protein Ipi1, N-terminal [IPR024679]", "Pre-rRNA-processing protein RIX1, N-terminal [IPR012583]", "Predicted HAD-superfamily phosphatase, subfamily IA/Epoxide hydrolase, N-terminal [IPR011945]", "Prenylcysteine lyase [IPR010795]", "Probable RNA-binding protein 19, RNA recognition motif 1 [IPR034418]", "Probable RNA-binding protein 19, RNA recognition motif 2 [IPR034417]", "Probable RNA-binding protein 19, RNA recognition motif 3 [IPR034419]", "Probable RNA-binding protein 19, RNA recognition motif 4 [IPR034420]", "Probable RNA-binding protein 19, RNA recognition motif 5 [IPR034423]", "Probable RNA-binding protein 19, RNA recognition motif 6 [IPR034421]", "Proliferating cell nuclear antigen, PCNA, C-terminal [IPR022649]", "Proliferating cell nuclear antigen, PCNA, N-terminal [IPR022648]", "Proline-tRNA ligase, class II, C-terminal [IPR016061]", "Prolyl 4-hydroxylase alpha subunit, Fe(2+) 2OG dioxygenase domain [IPR044862]", "Prolyl 4-hydroxylase alpha-subunit, N-terminal [IPR013547]", "Prolyl 4-hydroxylase, alpha subunit [IPR006620]", "Prolyl-tRNA synthetase, catalytic domain [IPR033721]", "Propionyl-coenzyme A carboxylase, BT domain [IPR041265]", "Prostaglandin E synthase 2, C-terminal [IPR034335]", "Proteasomal ATPase OB C-terminal domain [IPR032501]", "Proteasome activator Blm10, mid region [IPR032430]", "Proteasome activator PA28, C-terminal domain [IPR003186]", "Proteasome activator PA28, N-terminal domain [IPR003185]", "Proteasome activator complex subunit 4 C-terminal domain [IPR021843]", "Proteasome alpha-subunit, N-terminal domain [IPR000426]", "Proteasome beta subunit, C-terminal [IPR024689]", "Proteasome component (PCI) domain [IPR000717]", "Protein FAM210A/B-like domain [IPR009688]", "Protein HGH1 C-terminal [IPR007206]", "Protein HGH1 N-terminal [IPR007205]", "Protein Kinase B beta, catalytic domain [IPR034677]", "Protein Kinase B, pleckstrin homology domain [IPR039026]", "Protein O-mannosyl-transferase TMTC, DUF1736 [IPR013618]", "Protein RED, C-terminal [IPR012492]", "Protein SirB1, N-terminal [IPR032698]", "Protein Smaug, SAM domain [IPR037634]", "Protein disulfide-isomerase A3, first redox inactive TRX-like domain b [IPR041868]", "Protein disulfide-isomerase A4, TRX-like domain b [IPR041866]", "Protein disulfide-isomerase A5, N-terminal TRX-like b domain [IPR041865]", "Protein kinase C-like, phorbol ester/diacylglycerol-binding domain [IPR002219]", "Protein kinase domain [IPR000719]", "Protein kinase, C-terminal [IPR017892]", "Protein of unknown function DUF3504 [IPR021893]", "Protein of unknown function DUF3715 [IPR022188]", "Protein phosphatase 1 binding domain [IPR029334]", "Protein polybromo-1, Bromodomain 5 [IPR037968]", "Protein quaking, putative nuclear localisation signal [IPR032367]", "Protein-only RNase P, C-terminal [IPR031595]", "Protein-tyrosine phosphatase, catalytic [IPR003595]", "Prp31 C-terminal [IPR019175]", "Pseudouridine synthase II, N-terminal [IPR002501]", "Pseudouridine synthase, RsuA/RluA-like [IPR006145]", "Pseudouridine synthase, TruD, insertion domain [IPR011760]", "Pterin-binding domain [IPR000489]", "Pumilio homology domain [IPR033133]", "Pumilio, RNA binding domain [IPR033712]", "PurE domain [IPR000031]", "PurM-like, C-terminal domain [IPR010918]", "PurM-like, N-terminal domain [IPR016188]", "Putative 5-3 exonuclease [IPR004859]", "Putative RNA methylase domain [IPR000241]", "Putative RNA-binding protein 27, RNA recognition motif [IPR034451]", "Putative WW-binding domain and destruction box [IPR033461]", "Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain [IPR004099]", "Pyridoxamine kinase/Phosphomethylpyrimidine kinase [IPR013749]", "Pyrroline-5-carboxylate reductase, catalytic, N-terminal [IPR028939]", "Pyrroline-5-carboxylate reductase, dimerisation domain [IPR029036]", "Pyruvate carboxyltransferase [IPR000891]", "Pyruvate kinase, C-terminal [IPR015795]", "Pyruvate kinase, barrel [IPR015793]", "R3H domain [IPR001374]", "RABX5, catalytic core helical domain [IPR041545]", "RAD23A/RAD23B, UBA1 domain [IPR041811]", "RAD50, zinc hook [IPR013134]", "RAP domain [IPR013584]", "RBM10, OCRE domain [IPR035618]", "RBM12, RNA recognition motif 1 [IPR034591]", "RBM12, RNA recognition motif 2 [IPR034594]", "RBM12, RNA recognition motif 3 [IPR034855]", "RBM12, RNA recognition motif 4 [IPR034856]", "RBM12, RNA recognition motif 5 [IPR034854]", "RBM14, RNA recognition motif 1 [IPR034506]", "RBM14, RNA recognition motif 2 [IPR034507]", "RBM1CTR [IPR012604]", "RBM25, RNA recognition motif [IPR034268]", "RBM26, RNA recognition motif 1 [IPR034859]", "RBM26-like, RNA recognition motif 2 [IPR039511]", "RBM3/CIRBP, RNA recognition motif [IPR034278]", "RBM34, RNA recognition motif 1 [IPR034220]", "RBM34, RNA recognition motif 2 [IPR034221]", "RBM4, RNA recognition motif 1 [IPR034897]", "RBM4, RNA recognition motif 2 [IPR034898]", "RBM6, OCRE domain [IPR035617]", "RBM6, RNA recognition motif 1 [IPR034123]", "RBM6, RNA recognition motif 2 [IPR034125]", "RBM8, RNA recognition motif [IPR033744]", "RED-like, N-terminal [IPR012916]", "REKLES domain [IPR023334]", "RH1 domain [IPR034743]", "RH2 domain [IPR034744]", "RII binding domain [IPR018459]", "RING finger and SPRY domain-containing protein 1, SPRY domain [IPR035774]", "RING finger protein 219, RING finger [IPR035691]", "RING-type zinc-finger, LisH dimerisation motif [IPR027370]", "RL domain [IPR041252]", "RLI, domain 1 [IPR034348]", "RNA 3'-terminal phosphate cyclase domain [IPR023797]", "RNA 3'-terminal phosphate cyclase, insert domain [IPR013791]", "RNA binding activity-knot of a chromodomain [IPR025995]", "RNA exonuclease 4, DEDDh 3'-5' exonuclease domain [IPR037431]", "RNA helicase UPF1, 1B domain [IPR040812]", "RNA helicase UPF1, Cys/His rich zinc-binding domain [IPR018999]", "RNA helicase, DEAD-box type, Q motif [IPR014014]", "RNA methyltransferase bin3, C-terminal [IPR010675]", "RNA polymerase II-associated protein 1, C-terminal [IPR013929]", "RNA polymerase II-associated protein 1, N-terminal [IPR013930]", "RNA polymerase III Rpc82, C -terminal [IPR008806]", "RNA polymerase III subunit RPC82-related, helix-turn-helix [IPR013197]", "RNA polymerase Rpb1, domain 1 [IPR007080]", "RNA polymerase Rpb1, domain 3 [IPR007066]", "RNA polymerase Rpb1, domain 4 [IPR007083]", "RNA polymerase Rpb1, domain 5 [IPR007081]", "RNA polymerase Rpb1, domain 6 [IPR007075]", "RNA polymerase Rpb1, domain 7 [IPR007073]", "RNA polymerase Rpb2, domain 2 [IPR007642]", "RNA polymerase Rpb2, domain 3 [IPR007645]", "RNA polymerase Rpb2, domain 4 [IPR007646]", "RNA polymerase Rpb2, domain 5 [IPR007647]", "RNA polymerase Rpb2, domain 7 [IPR007641]", "RNA polymerase Rpb4/RPC9, core [IPR006590]", "RNA polymerase Rpb7-like , N-terminal [IPR005576]", "RNA polymerase, N-terminal [IPR006592]", "RNA polymerase, Rpb5, N-terminal [IPR005571]", "RNA polymerase, alpha subunit [IPR000722]", "RNA polymerase, beta subunit, protrusion [IPR007644]", "RNA polymerase, subunit H/Rpb5 C-terminal [IPR000783]", "RNA recognition motif domain [IPR000504]", "RNA recognition motif domain, eukaryote [IPR003954]", "RNA recognition motif, spliceosomal PrP8 [IPR019582]", "RNA-binding S4 domain [IPR002942]", "RNA-binding domain, S1 [IPR022967]", "RNA-binding protein 10, RNA recognition motif 2 [IPR034992]", "RNA-binding protein 5, RNA recognition motif 1 [IPR034991]", "RNA-binding protein 5, RNA recognition motif 2 [IPR034993]", "RNA-binding protein Musashi homologue, RNA recognition motif 1 [IPR034130]", "RNA-binding protein Musashi homologue, RNA recognition motif 2 [IPR034126]", "RNA-polymerase II-associated protein 3-like, C-terminal domain [IPR025986]", "RNA-recognition motif (RRM) Nup35-type domain [IPR007846]", "RNase L inhibitor RLI-like, possible metal-binding domain [IPR007209]", "ROCK, Rho binding domain [IPR015008]", "ROK, N-terminal [IPR012987]", "RPN1, N-terminal [IPR040892]", "RPN13, DEUBAD domain [IPR032368]", "RQC domain [IPR018982]", "RUN domain [IPR004012]", "RWD domain [IPR006575]", "RZZ complex, subunit KNTC1/ROD, C-terminal [IPR019527]", "Rab-GTPase-TBC domain [IPR000195]", "Rab-binding domain FIP-RBD [IPR019018]", "Rab3-GAP regulatory subunit, N-terminal [IPR032839]", "Rab3GAP catalytic subunit, C-terminal [IPR045698]", "Rab3GAP catalytic subunit, conserved domain [IPR026147]", "Rab3GAP regulatory subunit, C-terminal [IPR029257]", "Rabaptin coiled-coil domain [IPR018514]", "Rabaptin, GTPase-Rab5 binding domain [IPR015390]", "Rad21/Rec8-like protein, C-terminal, eukaryotic [IPR006909]", "Rad21/Rec8-like protein, N-terminal [IPR006910]", "Rad50, ATP-binding cassette domain [IPR045171]", "Rad50/SbcC-type AAA domain [IPR038729]", "Rad60/SUMO-like domain [IPR022617]", "Radical SAM [IPR007197]", "Radical SAM, C-terminal extension [IPR032432]", "Raf-like Ras-binding [IPR003116]", "Raly, RNA recognition motif [IPR034502]", "Ran binding domain [IPR000156]", "Ran binding protein 9/10, SPRY domain [IPR035782]", "Ran-GTPase activating protein 1, C-terminal [IPR009109]", "Ran-specific GTPase-activating protein 1, Ran-binding domain [IPR045256]", "Rap1 Myb domain [IPR015010]", "Raptor, N-terminal CASPase-like domain [IPR029347]", "Ras GTPase-activating domain [IPR001936]", "Ras guanine-nucleotide exchange factors catalytic domain [IPR001895]", "Ras-associating (RA) domain [IPR000159]", "Ras-like guanine nucleotide exchange factor, N-terminal [IPR000651]", "RasGAP protein, C-terminal [IPR000593]", "RecF/RecN/SMC, N-terminal [IPR003395]", "Redoxin [IPR013740]", "Regulator of G protein signalling-like domain [IPR015212]", "Regulator of MON1-CCZ1 complex, C-terminal [IPR009755]", "Replication factor A, C-terminal [IPR013955]", "Replication factor C, C-terminal [IPR013748]", "Replication factor-A protein 1, N-terminal [IPR007199]", "Replication protein A, C-terminal [IPR014892]", "Replication protein A, OB domain [IPR031657]", "Reticulon [IPR003388]", "Rho GTPase-activating protein domain [IPR000198]", "Rho GTPase-binding/formin homology 3 (GBD/FH3) domain [IPR014768]", "Rho-associated protein kinase 1, HR1 [IPR037310]", "Rhodanese-like domain [IPR001763]", "Ribonuclease H1, N-terminal [IPR011320]", "Ribonuclease HII/HIII domain [IPR024567]", "Ribonuclease II/R [IPR001900]", "Ribonuclease, PIN domain [IPR033411]", "Ribonucleoprotein PTB-binding 1, RNA recognition motif 1 [IPR034633]", "Ribonucleotide reductase large subunit, C-terminal [IPR000788]", "Ribonucleotide reductase large subunit, N-terminal [IPR013509]", "Ribonucleotide reductase, class I , alpha subunit [IPR013346]", "Ribose-phosphate pyrophosphokinase, N-terminal domain [IPR029099]", "Ribosomal L28e/Mak16 [IPR029004]", "Ribosomal Protein L6, KOW domain [IPR041997]", "Ribosomal Proteins L2, RNA binding domain [IPR022666]", "Ribosomal RNA adenine methylase transferase, N-terminal [IPR020598]", "Ribosomal RNA methyltransferase FtsJ domain [IPR002877]", "Ribosomal RNA methyltransferase Spb1, domain of unknown function DUF3381 [IPR024576]", "Ribosomal RNA methyltransferase, Spb1, C-terminal [IPR012920]", "Ribosomal RNA small subunit methyltransferase F, N-terminal [IPR031341]", "Ribosomal RNA-processing protein 14/surfeit locus protein 6, C-terminal domain [IPR029190]", "Ribosomal S6 kinase, N-terminal catalytic domain [IPR041906]", "Ribosomal protein 50S-L18Ae/60S-L20/60S-L18A [IPR023573]", "Ribosomal protein L10e/L16 [IPR016180]", "Ribosomal protein L11, C-terminal [IPR020783]", "Ribosomal protein L11, N-terminal [IPR020784]", "Ribosomal protein L14, KOW motif [IPR041985]", "Ribosomal protein L14e domain [IPR002784]", "Ribosomal protein L18e/L15P [IPR021131]", "Ribosomal protein L19, eukaryotic [IPR033935]", "Ribosomal protein L19/L19e [IPR000196]", "Ribosomal protein L2, C-terminal [IPR022669]", "Ribosomal protein L23/L25, N-terminal [IPR005633]", "Ribosomal protein L26/L24, KOW domain [IPR041988]", "Ribosomal protein L30, N-terminal [IPR012988]", "Ribosomal protein L30, ferredoxin-like fold domain [IPR016082]", "Ribosomal protein L46, N-terminal [IPR021757]", "Ribosomal protein L5 eukaryotic, C-terminal [IPR025607]", "Ribosomal protein L5, C-terminal [IPR031309]", "Ribosomal protein L5, N-terminal [IPR031310]", "Ribosomal protein L6, N-terminal [IPR005568]", "Ribosomal protein L6, alpha-beta domain [IPR020040]", "Ribosomal protein L7, eukaryotic/archaeal [IPR035808]", "Ribosomal protein L7/L12, C-terminal [IPR013823]", "Ribosomal protein L7/L12, oligomerisation [IPR008932]", "Ribosomal protein L7Ae/L30e/S12e/Gadd45 [IPR004038]", "Ribosomal protein L9, N-terminal [IPR020070]", "Ribosomal protein S10 domain [IPR027486]", "Ribosomal protein S13/S15, N-terminal [IPR012606]", "Ribosomal protein S23/S25, mitochondrial [IPR023611]", "Ribosomal protein S24/S35, mitochondrial, conserved domain [IPR019349]", "Ribosomal protein S3, C-terminal [IPR001351]", "Ribosomal protein S4, KOW domain [IPR041982]", "Ribosomal protein S4/S9, N-terminal [IPR001912]", "Ribosomal protein S4e, N-terminal [IPR013843]", "Ribosomal protein S4e, central region [IPR013845]", "Ribosomal protein S5, C-terminal [IPR005324]", "Ribosomal protein S5, N-terminal [IPR013810]", "Ribosomal protein S6 kinase alpha-3, C-terminal catalytic domain [IPR041905]", "Ribosomal protein S7 domain [IPR023798]", "Ribosomal protein/NADH dehydrogenase domain [IPR007741]", "Ribosome biogenesis protein BMS1/TSR1, C-terminal [IPR007034]", "Ribosome biogenesis protein Bms1, N-terminal [IPR037875]", "Ribosome maturation protein Sdo1/SBDS, C-terminal [IPR018978]", "Ribosome maturation protein Sdo1/SBDS, N-terminal [IPR019783]", "Ribosome receptor lysine/proline rich [IPR007794]", "Ribosome recycling factor domain [IPR023584]", "Ribosome-associated complex head domain [IPR032003]", "Ricin B, lectin domain [IPR000772]", "RmlD-like substrate binding domain [IPR029903]", "Rpa43, N-terminal ribonucleoprotein (RNP) domain [IPR041901]", "Rpn11/EIF3F, C-terminal [IPR024969]", "Rpn13/ADRM1, Pru domain [IPR044868]", "RrmJ-type ribose 2-O-methyltransferase domain [IPR025816]", "Rrp40, S1 domain [IPR037319]", "Rrp44-like cold shock domain [IPR033771]", "RuvB-like, AAA-lid domain [IPR041048]", "S-adenosyl-L-homocysteine hydrolase, NAD binding domain [IPR015878]", "S-adenosylmethionine synthetase, C-terminal [IPR022630]", "S-adenosylmethionine synthetase, N-terminal [IPR022628]", "S-adenosylmethionine synthetase, central domain [IPR022629]", "S1 domain [IPR003029]", "S1-like RNA binding domain [IPR025223]", "S100/CaBP-9k-type, calcium binding, subdomain [IPR013787]", "SAB domain [IPR007477]", "SAC domain [IPR002013]", "SAF domain [IPR013974]", "SAICAR synthetase/ADE2, N-terminal [IPR028923]", "SAM domain [IPR041418]", "SAM-dependent methyltransferase RsmB/NOP2-type [IPR001678]", "SANT domain [IPR017884]", "SANT/Myb domain [IPR001005]", "SAP domain [IPR003034]", "SARAH domain [IPR011524]", "SART3, RNA recognition motif 1 [IPR034217]", "SART3, RNA recognition motif 2 [IPR034218]", "SCAF4, RNA recognition motif [IPR034369]", "SCP2 sterol-binding domain [IPR003033]", "SDA1 domain [IPR007949]", "SEC23-interacting protein, SAM domain [IPR037603]", "SEPARIN core domain [IPR030397]", "SERRATE/Ars2 , C-terminal [IPR007042]", "SERRATE/Ars2, N-terminal [IPR021933]", "SET domain [IPR001214]", "SF3A2 domain [IPR031781]", "SF3A3 domain [IPR031774]", "SF3B4, RNA recognition motif 1 [IPR034158]", "SF3B4, RNA recognition motif 2 [IPR034159]", "SF3B6, RNA recognition motif [IPR034150]", "SGNH hydrolase-type esterase domain [IPR013830]", "SGS domain [IPR007699]", "SGTA, homodimerisation domain [IPR032374]", "SH2 domain [IPR000980]", "SH3 domain [IPR001452]", "SHARP, RNA recognition motif 1 [IPR034172]", "SHARP, RNA recognition motif 2 [IPR034173]", "SHARP, RNA recognition motif 3 [IPR034174]", "SHARP, RNA recognition motif 4 [IPR034175]", "SIS domain [IPR001347]", "SKI-interacting protein SKIP, SNW domain [IPR004015]", "SKP1 component, POZ domain [IPR016073]", "SKP1 component, dimerisation [IPR016072]", "SLC12A transporter, C-terminal [IPR018491]", "SLED domain [IPR021987]", "SLIDE domain [IPR015195]", "SLIRP, RNA recognition motif [IPR034152]", "SMAP1-like, ArfGAP domain [IPR044732]", "SMARCA1, N-terminal [IPR044755]", "SMARCC, C-terminal [IPR032451]", "SMARCC, N-terminal [IPR032450]", "SMARCC, SWIRM-associated domain [IPR032448]", "SMCs flexible hinge [IPR010935]", "SMYD3, SET domain [IPR044420]", "SNAP-25 domain [IPR000928]", "SNARE-complex protein Syntaxin-18, N-terminal [IPR019529]", "SNF2, N-terminal [IPR000330]", "SNX17, atypical FERM-like domain [IPR037836]", "SNX19, PX domain [IPR037909]", "SNX2, PX domain [IPR037918]", "SNX27, PX domain [IPR037833]", "SNX27, RA domain [IPR037835]", "SNX27, atypical FERM-like domain [IPR037827]", "SNX5, PX domain [IPR042135]", "SNX6, PX domain [IPR042136]", "SNX9, SH3 domain [IPR035558]", "SPF45, RNA recognition motif [IPR034653]", "SPRY domain [IPR003877]", "SPRY-associated [IPR006574]", "SR140, RNA recognition motif [IPR035009]", "SRA-YDG [IPR003105]", "SRCR domain [IPR001190]", "SRCR-like domain [IPR017448]", "SREK1, RNA recognition motif 2 [IPR034192]", "SRP9 domain [IPR039432]", "SRSF1, RNA recognition motif 1 [IPR034520]", "SRSF6, RNA recognition motif 1 [IPR034511]", "SRSF7, RNA recognition motif [IPR034651]", "SRSF9, RNA recognition motif 1 [IPR034503]", "SRSF9, RNA recognition motif 2 [IPR034995]", "SSRP1 domain [IPR024954]", "STAG [IPR013721]", "STAM1, SH3 domain [IPR035657]", "STAMBP/STALP-like, MPN domain [IPR044098]", "STAR protein, homodimerisation region [IPR032377]", "STARD7, START domain [IPR041949]", "START domain [IPR002913]", "STAT transcription factor, DNA-binding [IPR013801]", "STAT transcription factor, all-alpha domain [IPR013800]", "STAT transcription factor, protein interaction [IPR013799]", "STAT1, SH2 domain [IPR035859]", "STAT3, SH2 domain [IPR035855]", "STI1 domain [IPR041243]", "STRBP, first double-stranded RNA binding domain [IPR044472]", "SUI1 domain [IPR001950]", "SUMO-activating enzyme subunit 2, C-terminal domain [IPR032426]", "SUN coiled coil domain 2 [IPR040994]", "SUN domain [IPR012919]", "SUN domain-containing protein 1, N-terminal [IPR032680]", "SUZ-C domain [IPR024642]", "SWAP/Surp [IPR000061]", "SWI/SNF-like complex subunit BAF250, C-terminal [IPR033388]", "SWIB domain [IPR019835]", "SWIB/MDM2 domain [IPR003121]", "SWIRM domain [IPR007526]", "Saccharopine dehydrogenase, NADP binding domain [IPR005097]", "Saccharopine dehydrogenase-like, C-terminal [IPR032095]", "Sam68, tyrosine-rich domain [IPR032335]", "Saposin A-type domain [IPR003119]", "Saposin B type domain [IPR008139]", "Saposin B type, region 2 [IPR008138]", "Saposin-like type B, region 1 [IPR007856]", "Sas10 C-terminal domain [IPR018972]", "Scaffold protein Nfu/NifU, N-terminal [IPR014824]", "Schlafen group 3-like, DNA/RNA helicase domain [IPR018647]", "Schlafen, AlbA_2 domain [IPR007421]", "Sec16, central conserved domain [IPR024340]", "Sec23, C-terminal [IPR037550]", "Sec23/Sec24 beta-sandwich [IPR012990]", "Sec23/Sec24, helical domain [IPR006900]", "Sec23/Sec24, trunk domain [IPR006896]", "Sec24-like, trunk domain [IPR041742]", "Sec63 domain [IPR004179]", "Sec7 domain [IPR000904]", "Second polo-box domain [IPR033695]", "Sedolisin domain [IPR030400]", "Senescence/spartin-associated, C-terminal [IPR009686]", "Sentrin-specific protease 3/5, conserved domain [IPR045577]", "Septin-type guanine nucleotide-binding (G) domain [IPR030379]", "Sequestosome-1, PB1 domain [IPR034866]", "Sequestosome-1, UBA domain [IPR033741]", "Serine aminopeptidase, S33 [IPR022742]", "Serine hydroxymethyltransferase-like domain [IPR039429]", "Serine-tRNA ligase catalytic core domain [IPR033729]", "Serine-tRNA synthetase, type1, N-terminal [IPR015866]", "Serine-threonine protein phosphatase, N-terminal [IPR031675]", "Serine-threonine/tyrosine-protein kinase, catalytic domain [IPR001245]", "Serine/arginine-rich splicing factor SRSF4-like, RNA recognition motif 1 [IPR035585]", "Serine/threonine-protein PRP4, catalytic domain [IPR044092]", "Serine/threonine-protein kinase N, C2 domain [IPR037784]", "Serine/threonine-protein kinase N, first HR1 domain [IPR037313]", "Serine/threonine-protein kinase N1, second HR1 domain [IPR037317]", "Serine/threonine-protein kinase Nek9, catalytic domain [IPR042767]", "Serine/threonine-protein kinase OSR1/WNK, CCT domain [IPR024678]", "Serine/threonine-protein kinase greatwall, catalytic domain [IPR037638]", "Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase [IPR006186]", "Serpin H1, serpin domain [IPR033830]", "Serpin domain [IPR023796]", "Siah interacting protein, N-terminal [IPR015120]", "Signal recognition particle SRP54, helical bundle [IPR013822]", "Signal recognition particle receptor, alpha subunit, N-terminal [IPR007222]", "Signal recognition particle subunit SRP68, RNA-binding domain [IPR034652]", "Signal recognition particle, SRP54 subunit, GTPase domain [IPR000897]", "Signal recognition particle, SRP54 subunit, M-domain [IPR004125]", "Signal recognition particle, SRP72 subunit, RNA-binding [IPR013699]", "Signal transducer and activation of transcription 1, TAZ2 binding domain, C-terminal [IPR022752]", "Sin3, C-terminal [IPR031693]", "Sirtuin family, catalytic core domain [IPR026590]", "Ski2, N-terminal domain [IPR040801]", "Sm-like protein Lsm3 [IPR034105]", "Sm-like protein Lsm4 [IPR034101]", "Small G protein signalling modulator 1/2, Rab-binding domain [IPR021935]", "Small GTP-binding protein domain [IPR005225]", "Small acidic protein-like domain [IPR028124]", "Small nuclear ribonucleoprotein D1 [IPR034102]", "Small-subunit processome, Utp12 [IPR007148]", "Small-subunit processome, Utp13 [IPR013934]", "Small-subunit processome, Utp21 [IPR007319]", "Smc1, ATP-binding cassette domain [IPR028468]", "Smc2, ATP-binding cassette domain [IPR027120]", "Snf2, ATP coupling domain [IPR029295]", "Snu114, GTP-binding domain [IPR044121]", "Sof1-like protein [IPR007287]", "Solute carrier family 3 member 2, N-terminal domain [IPR031984]", "Sorting Nexin 1, PX domain [IPR034901]", "Sorting nexin 4, PX domain [IPR034902]", "Sorting nexin Vps5-like, C-terminal [IPR015404]", "Sorting nexin protein, WASP-binding domain [IPR019497]", "Sorting nexin, C-terminal [IPR013937]", "Sorting nexin, N-terminal [IPR005329]", "Sorting nexin-17/31, FERM domain [IPR040842]", "Sorting nexin-4, BAR domain [IPR037430]", "Sorting nexin-9, BAR domain [IPR037425]", "Sorting nexin-9, PX domain [IPR037426]", "Spen paralogue and orthologue SPOC, C-terminal [IPR012921]", "Spen paralogue/orthologue C-terminal, metazoa [IPR010912]", "Spermidine synthase, tetramerisation domain [IPR035246]", "Spermine synthase, N-terminal [IPR040900]", "Sphingolipid delta4-desaturase, N-terminal [IPR013866]", "Splicing factor 1, helix-hairpin domain [IPR032570]", "Splicing factor 3A subunit 1, conserved domain [IPR022030]", "Splicing factor 3A subunit 1, ubiquitin domain [IPR035563]", "Splicing factor 3B subunit 1 [IPR015016]", "Splicing factor ELAV/Hu, RNA recognition motif 1 [IPR034775]", "Splicing factor RBM39, linker [IPR029123]", "Splicing factor SF3a60 /Prp9 subunit, C-terminal [IPR024598]", "Splicing factor SF3a60 binding domain [IPR021966]", "Spp2/MOS2, G-patch domain [IPR026822]", "Spt5 C-terminal domain [IPR024945]", "Spt5 transcription elongation factor, N-terminal [IPR022581]", "Spt5, KOW domain repeat 1 [IPR041973]", "Spt5, KOW domain repeat 2 [IPR041975]", "Spt5, KOW domain repeat 3 [IPR041976]", "Spt5, KOW domain repeat 4 [IPR041977]", "Spt5, KOW domain repeat 5 [IPR041978]", "Spt5, KOW domain repeat 6 [IPR041980]", "Spt6 acidic, N-terminal domain [IPR028083]", "Spt6, SH2 domain [IPR035420]", "Spt6, SH2 domain, C terminus [IPR035018]", "Spt6, SH2 domain, N terminus [IPR035019]", "Squalene cyclase, C-terminal [IPR032696]", "Squalene cyclase, N-terminal [IPR032697]", "Squalene epoxidase [IPR013698]", "Srp40, C-terminal [IPR007718]", "StAR-related lipid transfer protein 3, C-terminal [IPR029867]", "Staphylococcal nuclease (SNase-like), OB-fold [IPR016071]", "Staufen 1, third double-stranded RNA binding domain [IPR044475]", "Staufen 2, first double-stranded RNA binding domain [IPR044476]", "Staufen 2, fourth double-stranded RNA binding domain [IPR044474]", "Staufen 2, second double-stranded RNA binding domain [IPR044464]", "Staufen 2, third double-stranded RNA binding domain [IPR044473]", "Staufen, C-terminal [IPR032478]", "Steadiness box (SB) domain [IPR017916]", "Sterile alpha motif domain [IPR001660]", "Sterol-sensing domain [IPR000731]", "Striatin, N-terminal [IPR013258]", "Strictosidine synthase, conserved region [IPR018119]", "Stromal interaction molecule 1, SAM domain [IPR037609]", "Stromal interaction molecule, Orai1-activating region [IPR032393]", "Stromalin conservative domain [IPR020839]", "Structural maintenance of chromosomes 3, ABC domain, eukaryotic [IPR041741]", "Structural maintenance of chromosomes 4, ABC domain, eukaryotic [IPR041738]", "Succinate dehydogenase/fumarate reductase N-terminal [IPR025192]", "Sulfatase, N-terminal [IPR000917]", "Sulfhydryl oxidase, Trx-like domain [IPR041269]", "Sulfhydryl oxidase, flavin adenine dinucleotide (FAD) binding domain [IPR040986]", "Suppressor of forked [IPR008847]", "Survival motor neuron [IPR010304]", "Sushi/SCR/CCP domain [IPR000436]", "Suv3, C-terminal domain 1 [IPR041082]", "Suv3, DEXQ-box helicase domain [IPR044774]", "Suv3, N-terminal [IPR041453]", "Symplekin C-terminal [IPR022075]", "Symplekin/Pta1, N-terminal [IPR032460]", "Synaptic functional regulator FMRP, KH0 domain [IPR040472]", "Synaptotagmin, SMP domain [IPR039010]", "Synaptotagmin-like mitochondrial-lipid-binding domain [IPR031468]", "Syntaxin 6, N-terminal [IPR015260]", "Syntaxin, N-terminal domain [IPR006011]", "Syntaxin-5, N-terminal, Sly1p-binding domain [IPR021538]", "Syntaxin-8, SNARE domain [IPR041875]", "TAF6, C-terminal HEAT repeat domain [IPR011442]", "TAP C-terminal (TAP-C) domain [IPR005637]", "TAR DNA-binding protein 43, N-terminal [IPR041105]", "TATA box binding protein associated factor (TAF) [IPR004823]", "TATA element modulatory factor 1, TATA binding [IPR022091]", "TATA-binding protein interacting (TIP20) [IPR013932]", "TBCE, ubiquitin-like (Ubl) domain [IPR044079]", "TCB1D9/TCB1D9B, PH-GRAM domain 1 [IPR036014]", "TCB1D9/TCB1D9B, PH-GRAM domain 2 [IPR036017]", "TFG, PB1 domain [IPR034857]", "TFIIEalpha/SarR/Rpc3 HTH domain [IPR024550]", "TGS [IPR004095]", "THIF-type NAD/FAD binding fold [IPR000594]", "THO complex subunit 2, N-terminal domain [IPR032302]", "THO complex, subunitTHOC2, C-terminal [IPR021418]", "THO complex, subunitTHOC2, N-terminal [IPR021726]", "THUMP domain [IPR004114]", "TIA-1, RNA recognition motif 2 [IPR034830]", "TIA-1, RNA recognition motif 3 [IPR034832]", "TIAR, RNA recognition motif 1 [IPR034492]", "TIAR, RNA recognition motif 2 [IPR034494]", "TIAR, RNA recognition motif 3 [IPR034496]", "TIF1-beta, RING finger, HC subclass [IPR042713]", "TIP49, P-loop domain [IPR010339]", "TNF receptor-associated factor 2, MATH domain [IPR037305]", "TNF receptor-associated factor, BIRC3 binding domain [IPR032070]", "TOG domain [IPR034085]", "TOPK, catalytic domain [IPR041989]", "TOPRIM domain [IPR006171]", "TPX2 central domain [IPR027330]", "TPX2, C-terminal [IPR027329]", "TRAM domain [IPR002792]", "TRAM/LAG1/CLN8 homology domain [IPR006634]", "TRAM1-like protein [IPR013599]", "TRASH domain [IPR011017]", "TRC8 N-terminal domain [IPR025754]", "TRF2-interacting telomeric protein/Rap1, C-terminal [IPR021661]", "TRIAD supradomain [IPR044066]", "TRIM21, PRY/SPRY domain [IPR035831]", "TRIM25, PRY/SPRY domain [IPR042753]", "TRMT2A, RNA recognition motif [IPR034262]", "TROVE domain [IPR008858]", "TSG101 and ALIX binding domain of CEP55 [IPR022008]", "TUTase nucleotidyltransferase domain [IPR045100]", "Talin, N-terminal F0 domain [IPR032425]", "Talin, central [IPR015224]", "Talin-1/2, rod-segment [IPR037438]", "Tankyrase 1-binding protein, C-terminal [IPR032764]", "Target SNARE coiled-coil homology domain [IPR000727]", "TatSF1-like, RNA recognition motif 1 [IPR034392]", "Telomerase activating protein Est1, N-terminal [IPR019458]", "Telomere length regulation protein, conserved domain [IPR019337]", "Telomere-associated protein Rif1, N-terminal [IPR022031]", "Tensin phosphatase, C2 domain [IPR014020]", "Tensin-type phosphatase domain [IPR029023]", "Testin, LIM domain 1 [IPR034958]", "Testin, LIM domain 2 [IPR034959]", "Testin, LIM domain 3 [IPR034960]", "Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain [IPR020631]", "Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain [IPR020630]", "Tetrapyrrole methylase [IPR000878]", "Tetratricopeptide repeat-like domain [IPR018704]", "Tetratricopeptide, SHNi-TPR domain [IPR019544]", "Tfc3, extended winged-helix domain [IPR035625]", "Thiamine pyrophosphate enzyme, C-terminal TPP-binding [IPR011766]", "Thiamine pyrophosphate enzyme, N-terminal TPP-binding domain [IPR012001]", "Thiamine pyrophosphate enzyme, central domain [IPR012000]", "Thioesterase [IPR001031]", "Thioesterase domain [IPR006683]", "Thiolase, C-terminal [IPR020617]", "Thiolase, N-terminal [IPR020616]", "Thioredoxin domain [IPR013766]", "Thioredoxin domain-containing protein 17-like domain [IPR010357]", "Thioredoxin-like fold [IPR012336]", "Thioredoxin-related transmembrane protein 2, thioredoxin domain [IPR037463]", "Threonine-tRNA ligase catalytic core domain [IPR033728]", "Threonyl/alanyl tRNA synthetase, SAD [IPR012947]", "Thymidylate kinase-like domain [IPR039430]", "Thymidylate synthase/dCMP hydroxymethylase domain [IPR023451]", "Tim10-like [IPR004217]", "Tim44-like domain [IPR007379]", "Timeless, C-terminal [IPR007725]", "Timeless, N-terminal [IPR006906]", "Toll/interleukin-1 receptor homology (TIR) domain [IPR000157]", "Topoisomerase I C-terminal domain [IPR025834]", "Trans-isoprenyl diphosphate synthases, head-to-head [IPR033904]", "Transcription elongation factor S-II, central domain [IPR003618]", "Transcription elongation factor Spt6, YqgF domain [IPR028231]", "Transcription elongation factor Spt6, helix-hairpin-helix motif [IPR032706]", "Transcription elongation factor, TFIIS/CRSP70, N-terminal, sub-type [IPR003617]", "Transcription factor CBF/NF-Y/archaeal histone domain [IPR003958]", "Transcription factor CP2, SAM domain [IPR037599]", "Transcription factor IIS, N-terminal [IPR017923]", "Transcription factor TFE/TFIIEalpha HTH domain [IPR017919]", "Transcription factor TFIIB, cyclin-like domain [IPR013150]", "Transcription factor TFIIE alpha subunit, C-terminal [IPR021600]", "Transcription initiation factor IIE subunit alpha, N-terminal [IPR002853]", "Transcription termination and cleavage factor, C-terminal domain [IPR026896]", "Transcriptional coactivator p15 (PC4), C-terminal [IPR003173]", "Transcriptional repressor p66, coiled-coil MBD2-interaction domain [IPR032346]", "Transferrin receptor protein 1/2, PA domain [IPR037324]", "Transferrin receptor-like, dimerisation domain [IPR007365]", "Transforming acidic coiled-coil-containing protein, C-terminal [IPR007707]", "Transketolase, C-terminal domain [IPR033248]", "Transketolase, N-terminal [IPR005474]", "Transketolase-like, pyrimidine-binding domain [IPR005475]", "Translation elongation factor EF1B, beta/delta subunit, guanine nucleotide exchange domain [IPR014038]", "Translation elongation factor EFG/EF2, domain IV [IPR005517]", "Translation elongation factor EFTs/EF1B, dimerisation [IPR014039]", "Translation elongation factor EFTu-like, domain 2 [IPR004161]", "Translation elongation factor EFTu/EF1A, C-terminal [IPR004160]", "Translation elongation factor, IF5A C-terminal [IPR020189]", "Translation initiation factor IF- 2, domain 3 [IPR023115]", "Translation initiation factor IF2/IF5 domain [IPR002735]", "Translation initiation factor eIF-2B subunit epsilon, N-terminal [IPR035543]", "Translation initiation factor eIF-2B subunit epsilon, W2 domain [IPR044123]", "Translation initiation factor, beta propellor-like domain [IPR013979]", "Translational (tr)-type GTP-binding domain [IPR000795]", "Translationally controlled tumour protein (TCTP) domain [IPR034737]", "Translocon Sec61/SecY, plug domain [IPR019561]", "Transmembrane protein 201, C-terminal [IPR018861]", "Treacle protein domain [IPR003993]", "Tripartite DENN domain [IPR037516]", "Tripeptidyl-peptidase II domain [IPR034051]", "TrmE-type guanine nucleotide-binding domain [IPR031168]", "TryX and NRX, thioredoxin domain [IPR045870]", "Tubulin-folding cofactor B, N-terminal ubiquitin-like domain [IPR045172]", "Tubulin-specific chaperone D, C-terminal [IPR022577]", "Tubulin/FtsZ, 2-layer sandwich domain [IPR018316]", "Tubulin/FtsZ, GTPase domain [IPR003008]", "Tudor domain [IPR002999]", "Tuftelin interacting protein, N-terminal domain [IPR022159]", "Tyrosine-protein kinase BAZ1B, bromodomain [IPR037375]", "Tyrosine-protein kinase ephrin type A/B receptor-like [IPR011641]", "Tyrosine-protein kinase, catalytic domain [IPR020635]", "Tyrosine-specific protein phosphatase, PTPase domain [IPR000242]", "Tyrosine-specific protein phosphatases domain [IPR000387]", "U-box domain [IPR003613]", "U1 small nuclear ribonucleoprotein A, RNA recognition motif 1 [IPR034407]", "U1 small nuclear ribonucleoprotein A, RNA recognition motif 2 [IPR034409]", "U1 small nuclear ribonucleoprotein of 70kDa N-terminal [IPR022023]", "U1-C, C2H2-type zinc finger [IPR013085]", "U2 small nuclear ribonucleoprotein B'', RNA recognition motif 2 [IPR034562]", "U2 small nuclear ribonucleoprotein B'', RNA recognition motif 1 [IPR034564]", "U2A'/phosphoprotein 32 family A, C-terminal [IPR003603]", "U3 small nucleolar RNA-associated protein 10, N-terminal [IPR022125]", "U3 small nucleolar RNA-associated protein 15, C-terminal [IPR018983]", "UAS [IPR006577]", "UBAC1, UBA domain 1 [IPR041926]", "UBAC1, UBA domain 2 [IPR041927]", "UBX domain [IPR001012]", "UBXN1, UBA domain [IPR041923]", "UDP-glucose:glycoprotein glucosyltransferase, thioredoxin-like domain 4 [IPR040525]", "UDP-glycosyltransferase family, conserved site [IPR035595]", "UGGT, thioredoxin-like domain 1 [IPR040693]", "UGGT, thioredoxin-like domain 2 [IPR040694]", "UGGT, thioredoxin-like domain 3 [IPR040692]", "UHRF1, tandem tudor domain [IPR021991]", "UNC-45/Cro1/She4, central domain [IPR024660]", "UPF0113, PUA domain [IPR005155]", "UPF0113, pre-PUA domain [IPR040598]", "USP8 dimerisation domain [IPR015063]", "UVR domain [IPR001943]", "Ubiquitin E2 variant, N-terminal [IPR008883]", "Ubiquitin carboxyl-terminal hydrolase 47, C-terminal [IPR045578]", "Ubiquitin carboxyl-terminal hydrolase 5, UBA1 domain [IPR041812]", "Ubiquitin carboxyl-terminal hydrolase 7, ICP0-binding domain [IPR024729]", "Ubiquitin carboxyl-terminal hydrolase, C-terminal [IPR029346]", "Ubiquitin conjugation factor E4, core [IPR019474]", "Ubiquitin specific protease domain [IPR028889]", "Ubiquitin system component CUE [IPR003892]", "Ubiquitin-activating enzyme E1, C-terminal [IPR018965]", "Ubiquitin-activating enzyme E1, FCCH domain [IPR032418]", "Ubiquitin-activating enzyme E1, four-helix bundle [IPR032420]", "Ubiquitin-activating enzyme, SCCH domain [IPR019572]", "Ubiquitin-associated domain [IPR015940]", "Ubiquitin-conjugating enzyme E2 [IPR000608]", "Ubiquitin-like domain [IPR000626]", "Ubiquitin-like domain, USP-type [IPR028135]", "Ubiquitin-like modifier-activating enzyme Atg7, N-terminal [IPR032197]", "Ubiquitin-protein ligase E3A, N-terminal zinc-binding domain [IPR032353]", "Ubiquitin-specific peptidase 48 [IPR033841]", "Ubiquitin-specific-processing protease 48, Ubl domain [IPR044743]", "Ubiquitin/SUMO-activating enzyme ubiquitin-like domain [IPR028077]", "Ubiquitinyl hydrolase, variant UBP zinc finger [IPR041432]", "Ubiquitinyl hydrolase-L5 [IPR033837]", "Ulp1 protease family, C-terminal catalytic domain [IPR003653]", "Uncharacterised domain CHP00451 [IPR004521]", "Uncharacterised domain NUC130/133, N-terminal [IPR012977]", "Uncharacterised domain NUC173 [IPR012978]", "Uncharacterised domain NUC202 [IPR012980]", "Upstream-binding protein 1, SAM domain [IPR037600]", "Uracil-DNA glycosylase-like [IPR005122]", "Uroporphyrinogen decarboxylase (URO-D) [IPR000257]", "Uso1/p115-like vesicle tethering protein, C-terminal [IPR006955]", "VASP tetramerisation [IPR014885]", "VASt domain [IPR031968]", "VHS domain [IPR002014]", "VIP36, lectin domain [IPR035664]", "VPS13, repeated coiled region [IPR031642]", "VPS9 domain [IPR003123]", "Vacuolar protein sorting-associated protein 13, C-terminal [IPR031645]", "Vacuolar protein sorting-associated protein 13, SHR-binding domain [IPR009543]", "Vacuolar protein sorting-associated protein 13, second N-terminal domain [IPR031646]", "Vacuolar protein sorting-associated protein 13-like, N-terminal domain [IPR026854]", "Vacuolar protein sorting-associated protein 13D, UBA domain [IPR041969]", "Vacuolar protein sorting-associated protein 4, MIT domain [IPR045253]", "Valyl tRNA synthetase, anticodon-binding domain [IPR033705]", "Vertebrate SNX3, PX domain [IPR042137]", "Vertebrate ubiquitin-conjugating enzyme E2 K, UBA domain [IPR042599]", "Vesicle tethering protein Uso1/P115-like , head domain [IPR006953]", "Vicinal oxygen chelate (VOC) domain [IPR037523]", "Vinculin-binding site-containing domain [IPR015009]", "Virilizer, N-terminal [IPR031801]", "Vitamin B12-dependent methionine synthase, activation domain [IPR004223]", "Vitamin K epoxide reductase [IPR012932]", "Vps16, C-terminal [IPR006925]", "Vps16, N-terminal [IPR006926]", "Vps4 oligomerisation, C-terminal [IPR015415]", "Vps53-like, N-terminal [IPR007234]", "W2 domain [IPR003307]", "WAPL domain [IPR012502]", "WD repeat-containing protein 18, C-terminal domain [IPR026987]", "WGR domain [IPR008893]", "WH1/EVH1 domain [IPR000697]", "WHEP-TRS domain [IPR000738]", "WHIM1 domain [IPR028942]", "WHIM2 domain [IPR028941]", "WSTF/Acf1/Cbp146 [IPR013136]", "WW domain [IPR001202]", "WWE domain [IPR004170]", "Wings apart-like protein, C-terminal [IPR022771]", "Wolframin, EF-hand domain [IPR045460]", "Wolframin, OB-fold domain [IPR045461]", "Wolframin, cysteine-rich domain [IPR045400]", "XPC-binding domain [IPR015360]", "XPG, N-terminal [IPR006085]", "XPG-I domain [IPR006086]", "XRCC1, first (central) BRCT domain [IPR045080]", "Xrn1, helical domain [IPR041412]", "YKT6, SNARE motif [IPR045848]", "YTH domain [IPR007275]", "YchF, C-terminal domain [IPR013029]", "YchF, N-terminal [IPR041706]", "YegS/DAGK, C-terminal domain [IPR045540]", "Yip1 domain [IPR006977]", "YjeF N-terminal domain [IPR004443]", "YqgF/RNase H-like domain [IPR006641]", "YrdC-like domain [IPR006070]", "Z-binding domain [IPR042371]", "ZAP, helix turn helix N-terminal domain [IPR041360]", "ZAP, zinc finger [IPR040954]", "ZC3H15/TMA46 family, C-terminal [IPR032378]", "ZCRB1, RNA recognition motif [IPR034219]", "ZN622/Rei1/Reh1, zinc finger C2H2-type [IPR041661]", "ZO-1, SH3 domain [IPR035597]", "ZU5 domain [IPR000906]", "Zasp-like motif [IPR006643]", "Zinc finger C2H2 AKAP95-type [IPR034736]", "Zinc finger C2H2-type [IPR013087]", "Zinc finger, A20-type [IPR002653]", "Zinc finger, B-box, chordata [IPR020457]", "Zinc finger, C2H2, LYAR-type [IPR014898]", "Zinc finger, C3HC-like [IPR012935]", "Zinc finger, C3HC4 RING-type [IPR018957]", "Zinc finger, CCCH-type [IPR000571]", "Zinc finger, CCHC-type [IPR001878]", "Zinc finger, CHCC-type [IPR019401]", "Zinc finger, CHHC-type [IPR012996]", "Zinc finger, CW-type [IPR011124]", "Zinc finger, CXXC-type [IPR002857]", "Zinc finger, ClpX C4-type [IPR010603]", "Zinc finger, DNA-directed DNA polymerase, family B, alpha [IPR015088]", "Zinc finger, FCS-type [IPR012313]", "Zinc finger, FPG/IleRS-type [IPR010663]", "Zinc finger, FYVE-related [IPR017455]", "Zinc finger, GATA-type [IPR000679]", "Zinc finger, LIM-type [IPR001781]", "Zinc finger, MIZ-type [IPR004181]", "Zinc finger, MYM-type [IPR010507]", "Zinc finger, MYND-type [IPR002893]", "Zinc finger, PARP-type [IPR001510]", "Zinc finger, PHD-finger [IPR019787]", "Zinc finger, PHD-type [IPR001965]", "Zinc finger, RING-CH-type [IPR011016]", "Zinc finger, RING-type [IPR001841]", "Zinc finger, RanBP2-type [IPR001876]", "Zinc finger, Sec23/Sec24-type [IPR006895]", "Zinc finger, TFIIB-type [IPR013137]", "Zinc finger, TFIIS-type [IPR001222]", "Zinc finger, TRAF-type [IPR001293]", "Zinc finger, UBP-type [IPR001607]", "Zinc finger, UBR-type [IPR003126]", "Zinc finger, ZPR1-type [IPR004457]", "Zinc finger, ZZ-type [IPR000433]", "Zinc finger, double-stranded RNA binding [IPR022755]", "Zinc knuckle CX2CX3GHX4C [IPR025829]", "Zinc-finger CCCH domain [IPR041686]", "Zinc-ribbon domain [IPR026870]", "Zn-dependent metallo-hydrolase, RNA specificity domain [IPR011108]", "cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain [IPR003117]", "cGMP-dependent protein kinase, interacting domain [IPR031775]", "dUTPase, trimeric [IPR033704]", "dUTPase-like [IPR029054]", "eIF3 subunit M, C-terminal helix domain [IPR040750]", "eIF3B, RNA recognition motif [IPR034363]", "eIF3G, RNA recognition motif [IPR034240]", "eIF3h, C-terminal [IPR045810]", "eIF4H, RNA recognition motif [IPR034229]", "eRF1 domain 1/Pelota-like [IPR005140]", "eRF1 domain 2 [IPR005141]", "eRF1 domain 3 [IPR005142]", "hnRNP A0, RNA recognition motif 1 [IPR034801]", "hnRNP A1, RNA recognition motif 1 [IPR034845]", "hnRNP A1, RNA recognition motif 2 [IPR034803]", "hnRNP A2/B1, RNA recognition motif 1 [IPR034486]", "hnRNP A3, RNA recognition motif 1 [IPR034513]", "hnRNP A3, RNA recognition motif 2 [IPR034516]", "hnRNP DL, RNA recognition motif 1 [IPR034847]", "hnRNP-L, RNA recognition motif 1 [IPR035005]", "hnRNP-L, RNA recognition motif 2 [IPR035008]", "hnRNP-L, RNA recognition motif 3 [IPR034816]", "hnRNP-L, RNA recognition motif 4 [IPR034817]", "hnRNPAB, RNA recognition motif 1 [IPR034846]", "hnRNPH3, RNA recognition motif 2 [IPR034970]", "hnRNPH3, RNA recognition motif 3 [IPR034969]", "hnRNPM, RNA recognition motif 3 [IPR034990]", "hnRPLL, RNA recognition motif 1 [IPR034985]", "hnRPLL, RNA recognition motif 2 [IPR034986]", "hnRPLL, RNA recognition motif 3 [IPR034983]", "hnRPLL, RNA recognition motif 4 [IPR034987]", "mRNA decay factor PAT1 domain [IPR019167]", "mRNA splicing factor Cwf21 domain [IPR013170]", "mRNA-decapping enzyme, C-terminal [IPR031953]", "p115RhoGEF, RGS domain [IPR037887]", "p21 activated kinase binding domain [IPR033923]", "p21-activated kinase 2, catalytic domain [IPR035064]", "p53 transactivation domain [IPR013872]", "p53, DNA-binding domain [IPR011615]", "p53, tetramerisation domain [IPR010991]", "p54nrb, RNA recognition motif 1 [IPR034552]", "rRNA-processing arch domain [IPR025696]", "snRNP70, RNA recognition motif [IPR034143]", "tRNA methyltransferase TRM10-type domain [IPR028564]", "tRNA methyltransferase TRMD/TRM10-type domain [IPR016009]", "tRNA pseudouridylate synthase B, C-terminal [IPR032819]", "tRNA synthetase, B5-domain [IPR005147]", "tRNA synthetases class I, catalytic domain [IPR032678]", "tRNA(Met) cytidine acetyltransferase TmcA, N-terminal [IPR013562]", "tRNA-binding domain [IPR002547]", "tRNA-guanine(15) transglycosylase-like [IPR002616]", "tRNase Z endonuclease [IPR027794]", "v-SNARE, coiled-coil homology domain [IPR042855]", "von Willebrand factor, type A [IPR002035]"], "available_proteins": ["AAR2", "AARS", "AARS2", "AASDHPPT", "AASS", "AATF", "ABCB1", "ABCB7", "ABCC1", "ABCD3", "ABCE1", "ABCF1", "ABCF2", "ABCF3", "ABHD10", "ABHD12", "ABHD14B", "ABHD6", "ABI1", "ACAA2", "ACACA", "ACACB", "ACAD11", "ACAD9", "ACADM", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACBD5", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT9", "ACOX1", "ACOX3", "ACP1", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTN1", "ACTN4", "ADAR", "ADD1", "ADD3", "ADH5", "ADNP", "ADRM1", "ADSL", "AFDN", "AFG3L2", "AGK", "AGL", "AGPAT1", "AGPAT5", "AGPS", "AHCY", "AHCYL1", "AHNAK", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK2", "AKAP12", "AKAP13", "AKAP8", "AKAP8L", "AKR1A1", "AKR1B1", "AKR7A2", "AKT2", "ALDH18A1", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALG1", "ALG11", "ALKBH5", "ALYREF", "AMOT", "ANAPC1", "ANAPC2", "ANAPC5", "ANGEL1", "ANKFY1", "ANKHD1", "ANKLE2", "ANKRD17", "ANO6", "ANP32B", "AP1B1", "AP1G1", "AP1M1", "AP1S2", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "AP3S1", "APEH", "APEX1", "APLP2", "APMAP", "APP", "APRT", "AQR", "ARAF", "ARCN1", "ARF4", "ARF6", "ARFGAP1", "ARFGAP2", "ARFIP1", "ARFIP2", "ARHGAP1", "ARHGAP17", "ARHGEF1", "ARHGEF2", "ARID1A", "ARID3B", "ARIH1", "ARIH2", "ARL1", "ARL2", "ARL3", "ARMC10", "ARMCX3", "ARMT1", "ASAH1", "ASCC2", "ASCC3", "ASNA1", "ASNS", "ASPH", "ATAD1", "ATAD2", "ATAD3A", "ATAD3B", "ATE1", "ATG7", "ATIC", "ATL2", "ATP13A1", "ATP1A1", "ATP2A2", "ATP2B1", "ATP5A1", "ATP5B", "ATP6V1A", "ATP6V1B2", "ATP6V1H", "ATP7B", "ATXN10", "ATXN2L", "AUP1", "AURKA", "AURKB", "BAG2", "BAG4", "BAG5", "BAG6", "BAIAP2", "BANP", "BAZ1A", "BAZ1B", "BCAP31", "BCS1L", "BIRC6", "BLVRA", "BMS1", "BOP1", "BPHL", "BRAP", "BRD2", "BRIX1", "BSDC1", "BSG", "BTAF1", "BTF3", "BUB1B", "BUD23", "BZW1", "BZW2", "C11orf58", "C1orf35", "C2CD5", "CACUL1", "CACYBP", "CAD", "CALM3", "CALU", "CAMK1", "CAMK2G", "CAND1", "CAP1", "CAPN1", "CAPN2", "CAPRIN1", "CARM1", "CARS", "CARS2", "CASK", "CBX1", "CBX3", "CBX5", "CBX8", "CCAR1", "CCAR2", "CCNB1", "CD2AP", "CD2BP2", "CD47", "CDC20", "CDC23", "CDC34", "CDC37", "CDC42", "CDC5L", "CDC7", "CDC73", "CDCA2", "CDCA8", "CDH2", "CDK1", "CDK2", "CDK4", "CDK5", "CDK6", "CDKAL1", "CEBPZ", "CECR2", "CELF2", "CENPV", "CEP290", "CEP44", "CEP55", "CERS1", "CERS2", "CETN2", "CFAP20", "CFL1", "CFL2", "CHAC2", "CHAF1A", "CHAF1B", "CHAMP1", "CHD1", "CHD1L", "CHD4", "CHERP", "CHID1", "CHORDC1", "CHRAC1", "CHTF18", "CIAPIN1", "CIRBP", "CISD1", "CISD2", "CKAP2", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLCN3", "CLCN7", "CLIC1", "CLIC4", "CLINT1", "CLPB", "CLPX", "CLTC", "CLU", "CLUH", "CMTR1", "CNDP2", "CNN3", "CNNM3", "CNNM4", "CNOT1", "CNOT2", "CNPY2", "COA3", "COASY", "COG4", "COIL", "COLEC12", "COMMD1", "COPA", "COPB1", "COPB2", "COPG1", "COPG2", "COPS2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS7A", "COPS8", "COPZ1", "COQ8A", "COQ9", "CORO1B", "CORO1C", "CORO7", "COTL1", "COX2", "COX6C", "CPD", "CPNE1", "CPNE3", "CPSF1", "CPSF2", "CPSF3", "CPSF6", "CPSF7", "CPT1A", "CPT2", "CRK", "CRKL", "CROT", "CRYZL1", "CSDE1", "CSE1L", "CSK", "CSNK1A1", "CSNK2A2", "CSRP2", "CSTB", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTCF", "CTDSPL2", "CTNNBL1", "CTPS1", "CTPS2", "CTSB", "CTSC", "CTTN", "CTTNBP2NL", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CWC27", "CWF19L1", "CYB5B", "CYB5D2", "CYB5R1", "CYB5R3", "CYFIP1", "CYFIP2", "DAG1", "DARS", "DARS2", "DAXX", "DAZAP1", "DBN1", "DBNL", "DBT", "DCAF13", "DCP1B", "DCTD", "DCTN1", "DCUN1D1", "DCUN1D5", "DDB1", "DDI2", "DDX1", "DDX10", "DDX17", "DDX18", "DDX20", "DDX21", "DDX23", "DDX24", "DDX27", "DDX28", "DDX39A", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX50", "DDX51", "DDX52", "DDX54", "DDX55", "DDX56", "DDX6", "DEGS1", "DEK", "DENR", "DFFA", "DGKE", "DHCR24", "DHFR", "DHX15", "DHX16", "DHX29", "DHX30", "DHX36", "DHX37", "DHX38", "DHX40", "DHX57", "DHX8", "DHX9", "DIAPH1", "DIAPH2", "DIAPH3", "DIDO1", "DIMT1", "DIS3", "DKC1", "DLAT", "DLD", "DLG3", "DLST", "DNAAF5", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC13", "DNAJC19", "DNAJC2", "DNAJC3", "DNAJC7", "DNAJC8", "DNAJC9", "DNM1L", "DNM2", "DNMT1", "DNTTIP2", "DOCK7", "DOLPP1", "DPH5", "DPM1", "DPP9", "DPYSL2", "DPYSL5", "DRG1", "DRG2", "DSC3", "DSG2", "DSP", "DST", "DSTN", "DTYMK", "DUSP12", "DUSP3", "DUSP9", "DUT", "DYNC1H1", "EARS2", "ECE1", "ECI2", "ECSIT", "EDC3", "EDC4", "EDF1", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EFCAB14", "EFL1", "EFTUD2", "EHD1", "EHD4", "EIF2A", "EIF2AK2", "EIF2B3", "EIF2B5", "EIF2D", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "ELAC2", "ELAVL1", "ELMO2", "ELMOD2", "ELOA", "ELOB", "ELOC", "ELP3", "EMC1", "EMC7", "EMD", "EML4", "ENAH", "ENDOD1", "ENO1", "ENO2", "EPB41", "EPB41L2", "EPB41L3", "EPB41L5", "EPHA7", "EPHX1", "EPHX2", "EPRS", "EPS15L1", "ERAL1", "ERAP1", "ERC1", "ERCC2", "ERCC3", "ERCC6L", "ERGIC2", "ERGIC3", "ERLIN1", "ERLIN2", "ERMP1", "ERP29", "ERP44", "ESF1", "ESPL1", "ESYT1", "ESYT2", "ETF1", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXO1", "EXOC2", "EXOC8", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC9", "EZR", "F11R", "FABP5", "FADS2", "FAF1", "FAF2", "FAH", "FAHD1", "FAM192A", "FAM208A", "FAM210A", "FAM3C", "FAM49B", "FANCI", "FAR1", "FARP1", "FARS2", "FARSA", "FARSB", "FASN", "FASTKD2", "FBXO21", "FBXO22", "FCGRT", "FDFT1", "FDXR", "FECH", "FEN1", "FERMT2", "FGFR1OP", "FH", "FHL1", "FHOD1", "FIP1L1", "FIS1", "FKBP10", "FKBP14", "FKBP1A", "FKBP2", "FKBP3", "FKBP4", "FKBP5", "FKBP7", "FKBP8", "FKBP9", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FMR1", "FOXRED1", "FSCN1", "FTL", "FTO", "FTSJ3", "FUBP1", "FUBP3", "FUCA1", "FUCA2", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GAK", "GAL", "GALK1", "GALNT1", "GALNT2", "GALNT4", "GANAB", "GAPDH", "GAPVD1", "GARS", "GART", "GATAD2A", "GATAD2B", "GBA", "GBE1", "GBF1", "GCAT", "GCC2", "GCDH", "GCN1", "GDAP1", "GDPD1", "GEMIN5", "GFM1", "GFPT1", "GGCT", "GGCX", "GHITM", "GIGYF2", "GINS2", "GINS3", "GINS4", "GLA", "GLB1", "GLDC", "GLO1", "GLOD4", "GLRX3", "GLS", "GLUD1", "GLYR1", "GM2A", "GMFB", "GMPPB", "GMPS", "GNG12", "GNL2", "GNL3", "GNL3L", "GNPAT", "GNPDA1", "GNS", "GOLGA2", "GOLGB1", "GOPC", "GORASP2", "GOT1", "GOT2", "GPAM", "GPAT4", "GPATCH4", "GPATCH8", "GPD2", "GPHN", "GPI", "GPKOW", "GPR89B", "GPS1", "GPT2", "GRAMD1A", "GRB2", "GRHPR", "GRSF1", "GRWD1", "GSPT1", "GSR", "GSS", "GSTK1", "GSTM3", "GSTO1", "GTF2B", "GTF2E1", "GTF3C1", "GTPBP1", "GTPBP10", "GTPBP3", "GTPBP4", "GUF1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACD3", "HACL1", "HADH", "HADHA", "HADHB", "HAT1", "HAUS3", "HBS1L", "HCFC1", "HDAC1", "HDAC2", "HDGF", "HDGFL2", "HDLBP", "HEATR1", "HEATR6", "HECTD1", "HELLS", "HEXA", "HEXB", "HGH1", "HGS", "HIBADH", "HIBCH", "HIKESHI", "HINT2", "HINT3", "HIRIP3", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLTF", "HMBS", "HMGB1", "HMGB2", "HMGB3", "HMGCL", "HMGCR", "HMGCS1", "HMMR", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPLL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HNRNPUL2", "HP1BP3", "HPRT1", "HSD17B4", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA14", "HSPA4", "HSPA4L", "HSPB1", "HSPBP1", "HSPH1", "HTATSF1", "HTRA2", "HUWE1", "IARS", "IARS2", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDI1", "IFT27", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IK", "IKBKG", "ILF2", "ILF3", "ILK", "ILKAP", "ILVBL", "IMP3", "IMP4", "IMPDH1", "IMPDH2", "INA", "INCENP", "INTS11", "INTS14", "INTS3", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IQGAP2", "IRGQ", "IRS4", "ISOC1", "ITCH", "ITGB1", "ITM2C", "IVD", "KARS", "KAT7", "KCTD12", "KCTD5", "KDELC2", "KDM1A", "KDM1B", "KDM2A", "KDM3B", "KHDRBS1", "KHSRP", "KIAA0319L", "KIAA0391", "KIAA1147", "KIAA1468", "KIF11", "KIF14", "KIF15", "KIF18B", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF4A", "KIF5B", "KIFC1", "KIN", "KMT2A", "KNTC1", "KPNA1", "KPNA2", "KPNA3", "KPNA6", "KPNB1", "KRI1", "KRR1", "KTN1", "L1RE1", "L2HGDH", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LASP1", "LBR", "LDHA", "LDHB", "LEMD2", "LEMD3", "LETM1", "LGALS3BP", "LIG1", "LIG3", "LIMA1", "LIPA", "LMAN2", "LMNA", "LMNB1", "LMNB2", "LNPEP", "LNPK", "LONP1", "LPCAT1", "LPGAT1", "LRBA", "LRP1", "LRPAP1", "LRPPRC", "LRRC47", "LSM12", "LSM2", "LSM3", "LSM4", "LSM6", "LSM7", "LSS", "LTA4H", "LYAR", "LYPLA1", "LYRM2", "LYSMD3", "LZIC", "M6PR", "MACF1", "MAD2L1", "MAGED2", "MAK16", "MAN2A1", "MAN2B1", "MANF", "MAP2K2", "MAPK1", "MAPK14", "MAPRE1", "MAPRE2", "MARC1", "MARCH5", "MARS", "MASTL", "MAT2A", "MAT2B", "MATR3", "MAVS", "MBD3", "MCAT", "MCCC1", "MCCC2", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCTS1", "MCU", "MDC1", "MDH1", "MDH2", "MDN1", "ME1", "ME2", "MECP2", "MED25", "MEPCE", "METAP2", "METTL13", "METTL7A", "METTL7B", "MFN1", "MFN2", "MGME1", "MIA2", "MIA3", "MICU1", "MICU2", "MINDY3", "MIPEP", "MKI67", "MKRN2", "MLEC", "MMAB", "MMS19", "MOGS", "MORF4L1", "MOSPD2", "MOV10", "MPP1", "MPP6", "MPRIP", "MPST", "MRC2", "MRE11", "MRPL11", "MRPL12", "MRPL15", "MRPL24", "MRPL39", "MRPL44", "MRPL45", "MRPL46", "MRPL58", "MRPL9", "MRPS23", "MRPS25", "MRPS35", "MRPS5", "MRPS7", "MRRF", "MRTO4", "MSH2", "MSH3", "MSH6", "MSI2", "MSMO1", "MSN", "MSTO1", "MTA1", "MTA2", "MTAP", "MTBP", "MTHFD1", "MTHFD1L", "MTHFD2", "MTMR14", "MTMR2", "MTOR", "MTPAP", "MTR", "MTX1", "MTX2", "MUT", "MVK", "MYEF2", "MYH10", "MYH9", "MYL6", "MYO1B", "MYO1C", "MYO1D", "MYO6", "NAA40", "NAA50", "NAE1", "NAGA", "NAGLU", "NAMPT", "NANS", "NARS", "NASP", "NAT10", "NAXE", "NCAPD2", "NCAPD3", "NCAPG", "NCBP1", "NCL", "NCLN", "NCSTN", "NDUFA8", "NDUFA9", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS6", "NDUFS7", "NDUFS8", "NDUFV1", "NDUFV2", "NECAP2", "NEFL", "NEFM", "NEK9", "NELFE", "NEMF", "NENF", "NES", "NFATC2IP", "NFU1", "NHP2", "NIFK", "NIP7", "NIPSNAP1", "NIPSNAP2", "NKRF", "NKTR", "NLE1", "NLN", "NLRX1", "NME1", "NMT1", "NNT", "NOA1", "NOB1", "NOC3L", "NOC4L", "NOL10", "NOL11", "NOL6", "NOL7", "NOL8", "NOL9", "NOLC1", "NOM1", "NONO", "NOP2", "NOP56", "NOP58", "NOSIP", "NPC1", "NPC2", "NPEPPS", "NPLOC4", "NPM1", "NRDC", "NSD2", "NSDHL", "NSF", "NSMCE2", "NSUN2", "NSUN5", "NTHL1", "NTPCR", "NUB1", "NUCB1", "NUCB2", "NUDC", "NUDCD1", "NUDCD2", "NUDT1", "NUDT21", "NUDT5", "NUDT9", "NUF2", "NUP133", "NUP153", "NUP155", "NUP188", "NUP210", "NUP214", "NUP35", "NUP50", "NUP54", "NUP62", "NUP98", "NUTF2", "NVL", "NXF1", "NXN", "OCIAD1", "OCLN", "OCRL", "OGDH", "OGT", "OLA1", "OPA1", "OSBP", "OSBPL3", "OSBPL6", "OSBPL8", "OSBPL9", "OSGEP", "OTUB1", "OTUD4", "OTUD7B", "OXA1L", "OXCT1", "OXSR1", "P3H1", "P4HA1", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PAFAH1B1", "PAFAH1B2", "PAFAH1B3", "PAICS", "PAIP1", "PAIP2", "PAK2", "PALLD", "PANK4", "PAPOLA", "PARK7", "PARN", "PARP1", "PATL1", "PBDC1", "PBK", "PBRM1", "PC", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCID2", "PCK2", "PCLAF", "PCM1", "PCNA", "PCYOX1", "PDAP1", "PDCD11", "PDCD6", "PDCD6IP", "PDCL3", "PDE12", "PDE6D", "PDHA1", "PDHB", "PDIA3", "PDIA4", "PDIA5", "PDIA6", "PDK3", "PDLIM1", "PDLIM5", "PDLIM7", "PDPR", "PDXK", "PEF1", "PELO", "PELP1", "PEPD", "PES1", "PEX14", "PFAS", "PFKL", "PFKM", "PFKP", "PGD", "PGLS", "PGM1", "PGM2", "PGM3", "PGRMC1", "PGRMC2", "PHAX", "PHB", "PHB2", "PHC2", "PHF6", "PHGDH", "PHIP", "PHKA1", "PI4K2A", "PI4KB", "PICALM", "PIK3R4", "PIN4", "PINX1", "PIP4K2C", "PIR", "PITHD1", "PITRM1", "PKM", "PKMYT1", "PKN1", "PKN2", "PLAA", "PLCG1", "PLD3", "PLD6", "PLEC", "PLK1", "PLOD1", "PLOD2", "PLPBP", "PLS3", "PM20D2", "PMPCA", "PMPCB", "PNKP", "PNN", "PNO1", "PNP", "PNPLA6", "PNPT1", "POGZ", "POLA1", "POLA2", "POLD1", "POLD2", "POLDIP2", "POLDIP3", "POLE", "POLE3", "POLE4", "POLR1A", "POLR1B", "POLR1C", "POLR2A", "POLR2B", "POLR2C", "POLR2D", "POLR2E", "POLR2G", "POLR3A", "POLR3C", "POLRMT", "POP1", "POR", "PPAN", "PPAT", "PPIB", "PPIC", "PPID", "PPIF", "PPIH", "PPIL1", "PPIL3", "PPIL4", "PPM1G", "PPME1", "PPOX", "PPP1CA", "PPP1CB", "PPP1R10", "PPP1R12A", "PPP1R8", "PPP3CA", "PPP4C", "PPP4R1", "PPP4R3A", "PPP5C", "PPP6C", "PPWD1", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREP", "PREPL", "PRKAA2", "PRKACA", "PRKAG1", "PRKAR1A", "PRKAR2A", "PRKCB", "PRKCSH", "PRKDC", "PRKRA", "PRMT1", "PRMT3", "PRMT5", "PRPF19", "PRPF31", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPSAP1", "PRPSAP2", "PRRC1", "PRRC2A", "PRRC2C", "PRTFDC1", "PSAP", "PSAT1", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD11", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD6", "PSMD7", "PSMD8", "PSMD9", "PSME1", "PSME2", "PSME3", "PSME4", "PSPC1", "PTBP1", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK7", "PTPMT1", "PTPN1", "PTPN11", "PTPRF", "PUF60", "PUM1", "PUM3", "PUS7", "PWP2", "PXN", "PYCR1", "PYCR2", "PYCR3", "Q6ZSR9", "QARS", "QKI", "QRSL1", "QSOX2", "QTRT2", "RAB10", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB1B", "RAB21", "RAB24", "RAB31", "RAB39A", "RAB3GAP1", "RAB3GAP2", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RAB8A", "RAB9A", "RABEP1", "RABGAP1", "RAC1", "RACGAP1", "RAD21", "RAD23A", "RAD23B", "RAD50", "RALA", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP9", "RANGAP1", "RAP2B", "RAPGEF2", "RARS", "RARS2", "RAVER1", "RBBP6", "RBBP7", "RBM10", "RBM12", "RBM14", "RBM17", "RBM19", "RBM22", "RBM25", "RBM26", "RBM27", "RBM28", "RBM34", "RBM39", "RBM4", "RBM5", "RBM6", "RBM8A", "RBMX", "RBP1", "RCL1", "RCN1", "RCN2", "RDX", "RECQL", "REXO4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RHBDD2", "RHEB", "RHOG", "RHOT1", "RHOT2", "RIF1", "RMC1", "RMND1", "RNASEH2A", "RNF139", "RNF14", "RNF20", "RNF219", "RNF40", "RNPEP", "ROCK1", "RPA1", "RPA2", "RPAP1", "RPAP3", "RPF1", "RPF2", "RPL10", "RPL11", "RPL12", "RPL14", "RPL18", "RPL18A", "RPL19", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL30", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS2", "RPS20", "RPS3", "RPS4X", "RPS5", "RPS6KA1", "RPS6KA3", "RPS9", "RPSA", "RPTOR", "RPUSD3", "RRBP1", "RRM1", "RRP12", "RSL24D1", "RSPRY1", "RTN2", "RTN3", "RTN4", "RTN4IP1", "RUFY1", "RUVBL1", "RUVBL2", "S100A11", "S100A13", "SACM1L", "SAE1", "SAFB", "SAFB2", "SAMD4B", "SAMHD1", "SAMM50", "SAR1A", "SARM1", "SARNP", "SARS", "SARS2", "SART3", "SBDS", "SCAF4", "SCCPDH", "SCML2", "SCO2", "SCP2", "SCRIB", "SDAD1", "SDCBP", "SDF4", "SDHA", "SDHB", "SDR39U1", "SEC11A", "SEC16A", "SEC22B", "SEC23A", "SEC23B", "SEC23IP", "SEC24A", "SEC24B", "SEC24C", "SEC24D", "SEC31A", "SEC61A1", "SEC63", "SEL1L", "SENP3", "SEPHS1", "SEPT11", "SEPT2", "SEPT6", "SEPT7", "SEPT9", "SERBP1", "SERPINB6", "SERPINH1", "SEZ6L2", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SGTA", "SH3GL1", "SH3GLB1", "SH3GLB2", "SHMT1", "SHMT2", "SIN3A", "SIRT1", "SKIV2L", "SKIV2L2", "SKP1", "SKP2", "SLC12A9", "SLC16A1", "SLC25A12", "SLC25A13", "SLC25A24", "SLC27A4", "SLC3A2", "SLC4A1AP", "SLC4A7", "SLC6A15", "SLC9A3R1", "SLFN11", "SLIRP", "SLIT2", "SLK", "SLTM", "SMAP1", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC6", "SMG5", "SMN1*", "SMNDC1", "SMS", "SMU1", "SMYD3", "SNAP23", "SND1", "SNRNP200", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPC", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNW1", "SNX1", "SNX12", "SNX17", "SNX19", "SNX2", "SNX27", "SNX3", "SNX4", "SNX5", "SNX6", "SNX9", "SOD2", "SON", "SORD", "SPAG9", "SPART", "SPATA5", "SPATA5L1", "SPC25", "SPECC1L", "SPEN", "SPHK2", "SPNS1", "SPTAN1", "SPTBN1", "SPTBN2", "SPTLC1", "SPTLC2", "SQLE", "SQSTM1", "SRCAP", "SREK1", "SRI", "SRM", "SRP54", "SRP68", "SRP72", "SRP9", "SRPK1", "SRPK2", "SRPRA", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF3", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSRP1", "STAG1", "STAG2", "STAM", "STAMBP", "STARD3", "STARD3NL", "STARD7", "STAT1", "STAT3", "STAU1", "STAU2", "STIM1", "STIP1", "STK26", "STK4", "STOM", "STOML2", "STRBP", "STRN", "STX10", "STX12", "STX18", "STX3", "STX4", "STX5", "STX7", "STX8", "STXBP4", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGP2", "SUGT1", "SUN1", "SUN2", "SUPT16H", "SUPT5H", "SUPT6H", "SUPV3L1", "SURF6", "SUZ12", "SV2A", "SYAP1", "SYMPK", "SYNCRIP", "SYNE2", "SYNGR2", "SYNJ2BP", "TAB1", "TACC3", "TAF15", "TAF6L", "TAGLN2", "TAOK1", "TAP1", "TARDBP", "TARS", "TARS2", "TBC1D13", "TBC1D15", "TBC1D2B", "TBC1D4", "TBC1D9B", "TBCB", "TBCD", "TBCE", "TBL3", "TBRG4", "TCAF1", "TCEA1", "TCERG1", "TCOF1", "TDRKH", "TECR", "TELO2", "TERF2IP", "TES", "TEX10", "TFAM", "TFB1M", "TFCP2", "TFG", "TFIP11", "TFRC", "THOC1", "THOC2", "THOC3", "THOP1", "THUMPD1", "THUMPD3", "THYN1", "TIA1", "TIAL1", "TIMELESS", "TIMM10", "TIMM10B", "TIMM13", "TIMM44", "TIMM50", "TIMM8B", "TIMM9", "TJP1", "TKT", "TLCD1", "TLN1", "TMED10", "TMED2", "TMED4", "TMED5", "TMED7", "TMED9", "TMEM201", "TMEM205", "TMEM97", "TMF1", "TMPO", "TMPO", "TMPPE", "TMTC3", "TMX1", "TMX2", "TMX3", "TMX4", "TNKS1BP1", "TNPO1", "TNPO2", "TNPO3", "TOE1", "TOP1", "TOP2A", "TOP2B", "TOX4", "TP53", "TPP1", "TPP2", "TPR", "TPT1", "TPX2", "TRA2A", "TRA2B", "TRAF2", "TRAM1", "TRAP1", "TRIM21", "TRIM25", "TRIM28", "TRIM33", "TRIP12", "TRIP13", "TRMT10C", "TRMT11", "TRMT1L", "TRMT2A", "TROVE2", "TRRAP", "TRUB1", "TSFM", "TSG101", "TSR1", "TST", "TTC4", "TTK", "TUBB", "TUBB2A", "TUBB2B", "TUBB3", "TUBB4B", "TUBB6", "TUBGCP2", "TUBGCP3", "TUBGCP4", "TUFM", "TWF1", "TWF2", "TWISTNB", "TWNK", "TXNDC12", "TXNDC17", "TXNDC5", "TXNDC9", "TXNL1", "TXNRD1", "TYMS", "U2AF1", "U2AF2", "U2SURP", "UBA1", "UBA2", "UBA3", "UBA6", "UBAC1", "UBAP2L", "UBE2J1", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2O", "UBE2S", "UBE3A", "UBE4A", "UBE4B", "UBLCP1", "UBP1", "UBQLN2", "UBQLN4", "UBR4", "UBR5", "UBTF", "UBXN1", "UBXN4", "UBXN7", "UCHL5", "UCK2", "UGGT1", "UGT8", "UHRF1", "ULK3", "UMPS", "UNC119", "UNC119B", "UNC45A", "UNG", "UPF1", "UQCRC1", "UQCRC2", "URB1", "UROD", "USO1", "USP10", "USP11", "USP14", "USP28", "USP36", "USP39", "USP47", "USP48", "USP5", "USP7", "USP9X", "UTP15", "UTP20", "UTP3", "UTRN", "VAMP7", "VAPA", "VAPB", "VARS1", "VAT1", "VCP", "VIM", "VIRMA", "VKORC1L1", "VPS13A", "VPS13D", "VPS16", "VPS18", "VPS29", "VPS37B", "VPS4A", "VPS4B", "VPS51", "VPS53", "VRK1", "VRK3", "WAPL", "WARS", "WBP2", "WDHD1", "WDR12", "WDR18", "WDR26", "WDR3", "WDR36", "WDR43", "WDR46", "WFS1", "WIZ", "XPNPEP1", "XPNPEP3", "XPO1", "XPO5", "XPO7", "XPOT", "XRCC1", "XRCC5", "XRCC6", "XRN2", "YARS", "YBX1", "YBX3", "YIPF4", "YKT6", "YME1L1", "YRDC", "YTHDC1", "YTHDC2", "YTHDF3", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2", "ZC3H11A", "ZC3H14", "ZC3H15", "ZC3H18", "ZC3HAV1", "ZC3HC1", "ZCCHC3", "ZCRB1", "ZDHHC13", "ZFR", "ZFYVE16", "ZMPSTE24", "ZMYM2", "ZNF207", "ZNF280C", "ZNF281", "ZNF318", "ZNF326", "ZNF512", "ZNF512B", "ZNF622", "ZNF638", "ZPR1", "ZRANB2", "ZYX"], "leading_proteins": ["ABCB1", "ABCB7", "ABCC1", "ACOX1", "ACSF3", "ACSL1", "ACSL3", "ACTN1", "ACTN4", "ADD3", "AGK", "AGPAT1", "AGPAT5", "AIFM1", "AKAP8", "ALG1", "ANKLE2", "APLP2", "ARMC10", "ATAD3A", "ATIC", "ATP13A1", "ATP1A1", "ATP2A2", "ATP7B", "BSG", "CBX1", "CD47", "CERS2", "CIRBP", "CLCN7", "CLPB", "CNNM3", "CNNM4", "COPS5", "COPS6", "CTDSPL2", "CTPS2", "CYB5B", "CYB5R1", "DEGS1", "DHCR24", "DNAJA2", "DNAJA3", "DUSP9", "EFCAB14", "EHD4", "EIF2B3", "EIF3F", "EIF3H", "ELMOD2", "ELOC", "EPHA7", "ERAP1", "ERGIC3", "ERLIN1", "ESYT1", "FADS2", "FASN", "FKBP10", "FKBP14", "FKBP7", "FKBP9", "FLOT1", "FLOT2", "FOXRED1", "FUCA2", "GALNT4", "GLA", "GNPAT", "GPHN", "HACD3", "HADHA", "HGS", "HLA-A", "HLA-B", "HLA-C", "HNRNPAB", "HNRNPF", "HNRNPH2", "HNRNPL", "HNRNPLL", "HNRNPUL2", "HSDL2", "IMP4", "INA", "KCTD5", "KHSRP", "KMT2A", "KPNA3", "LBR", "LEMD3", "LETM1", "LMNA", "LMNB1", "LMNB2", "LNPEP", "LPCAT1", "LPGAT1", "LYRM2", "MAPRE1", "ME1", "METTL7A", "MFN1", "MFN2", "MICU2", "MIPEP", "MKRN2", "MPP6", "MPST", "MRPL45", "MRPS7", "NEFL", "NEFM", "NIPSNAP1", "NLN", "NUCB1", "NUCB2", "NUP155", "OGDH", "OLA1", "OPA1", "P4HA1", "PABPC4", "PDPR", "PGRMC1", "PGRMC2", "PHB", "PHB2", "PHC2", "PITRM1", "PLD6", "PMPCA", "PNPLA6", "POR", "PPAN", "PRKAR1A", "PSMD14", "PSMD7", "PSPC1", "PUF60", "PUM3", "PYCR2", "PYCR3", "RARS", "RBBP7", "RBM17", "RBM39", "RBMX", "RCN2", "RPF1", "RPF2", "RPS6KA3", "RTN3", "RTN4", "RUVBL2", "SAMD4B", "SAMHD1", "SARM1", "SCO2", "SDF4", "SEC22B", "SEC23B", "SEC23IP", "SFPQ", "SHMT2", "SLC16A1", "SLC25A13", "SLC25A24", "SLC27A4", "SLC3A2", "SMN1*", "SMYD3", "SNX2", "SNX5", "SNX6", "SQSTM1", "STAMBP", "STARD3", "STARD3NL", "STIM1", "STOM", "STOML2", "STX10", "STX12", "STX4", "STX5", "STX8", "SUN2", "SYNCRIP", "SYNGR2", "TAP1", "TARS2", "TIMM10B", "TIMM8B", "TIMM9", "TLCD1", "TMED10", "TMED2", "TMED7", "TMPO", "TMX1", "TMX2", "TMX3", "TMX4", "TRAM1", "UNC119", "UNC119B", "UQCRC2", "VIM", "VPS13D", "YKT6", "ZNF326"]} \ No newline at end of file diff --git a/interpro_family/advanced/idx2term.json b/interpro_family/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..ebb8ddfe226dabe2c5f86ff9cb9b93374451f493 --- /dev/null +++ b/interpro_family/advanced/idx2term.json @@ -0,0 +1 @@ +{"0": "Mitochondrial carrier protein [IPR002067]", "1": "Syntaxin [IPR045242]"} \ No newline at end of file diff --git a/interpro_family/advanced/plot_0.png b/interpro_family/advanced/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..a84483250bfaae92433951337d1f79c8d6ab4eb4 --- /dev/null +++ b/interpro_family/advanced/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:4f1d9f2af2a3843830e19af311ab042efcae3c16d0fbedecf3cf1a3d8f160249 +size 176426 diff --git a/interpro_family/advanced/plot_1.png b/interpro_family/advanced/plot_1.png new file mode 100644 index 0000000000000000000000000000000000000000..1895f2b37465500fa90db099263d62c794e8c6e7 --- /dev/null +++ b/interpro_family/advanced/plot_1.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:ba8cc3a82ab01eb093735772b24e51704404669ede6b37b78c0603c08a48b272 +size 169557 diff --git a/interpro_family/basic/idx2term.json b/interpro_family/basic/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..7a7cbbee9bb3b537d9e33f830a80a1496d3f981d --- /dev/null +++ b/interpro_family/basic/idx2term.json @@ -0,0 +1 @@ +{"0": "Mitochondrial carrier protein [IPR002067]", "1": "Syntaxin [IPR045242]", "2": "Short-chain dehydrogenase/reductase SDR [IPR002347]"} \ No newline at end of file diff --git a/interpro_family/basic/plot_0.png b/interpro_family/basic/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..a64596f44d383590374fb7a999914e025b31072c --- /dev/null +++ b/interpro_family/basic/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:855229c75bf32e2dcd53a747a901a61fc09c00fcdee4f0ee6193006654a18a29 +size 141675 diff --git a/interpro_family/basic/plot_1.png b/interpro_family/basic/plot_1.png new file mode 100644 index 0000000000000000000000000000000000000000..065e607e63d7d8a6dcf3c8ebe08d1c5e86aca345 --- /dev/null +++ b/interpro_family/basic/plot_1.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:dd7fa9193df693d530e998f75fe8a4abc903ff36b22eedfc939bce65c58b9202 +size 130324 diff --git a/interpro_family/basic/plot_2.png b/interpro_family/basic/plot_2.png new file mode 100644 index 0000000000000000000000000000000000000000..999fe7080b55d3a411b0aa2b1a2b2d590594aa52 --- /dev/null +++ b/interpro_family/basic/plot_2.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:8d939150a4019934a942dbd0ae7015bf175ec0ec067b7a8b233a601d7f55f46c +size 141921 diff --git a/interpro_family/consensus.joblib b/interpro_family/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..4e9f6a675c3584f55974c8643430dd263f06a172 --- /dev/null +++ b/interpro_family/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:18f557dedb4e2b5f435f31c8e3d33d63ccc430eb83916fe6498272d6f441066f +size 371236 diff --git a/interpro_family/df_merge.tsv b/interpro_family/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..0ac685bee93d93455af952ee94e6217041fa555a --- /dev/null +++ b/interpro_family/df_merge.tsv @@ -0,0 +1,4 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Mitochondrial carrier protein [IPR002067] 11 13 2.9238394291656404 0.003457430455511 5.686893203883495 11.07766990291262 0.8032246115450145 0.31892620527414 3.2338505495684404 1.5403272908315857 1.3918146051602212 0.3274613788058813 1.4585697686775958e-06 1.0 1.0 0.0111687214620054 1.820886534068759e-06 +Syntaxin [IPR045242] 5 7 2.304635403447291 0.0211870014404662 2.674757281553398 5.815533980582524 0.7134969984167514 0.3462495636510407 1.4434464182805606 1.4295601388514203 1.142372356309129 0.3001529293380739 0.0240983907929731 1.0 0.1253337423142017 0.2857421618237076 0.0260269107064552 +P-type ATPase [IPR001757] 4 5 2.063733772997012 0.039042965342845 2.941747572815534 6.145631067961165 0.9567723497044874 0.2732808833570771 1.8358630293390923 1.459204245106796 1.2102525517005158 0.2943240638910574 0.0167170186699105 1.0 1.0 0.4108142183097444 0.0184399659986801 diff --git a/interpro_family/metrics.json b/interpro_family/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..bb69233dece795704b194a2b8d6a400aa930c432 --- /dev/null +++ b/interpro_family/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2974, + "annotations_size": 2323, + "title": "Average number of proteins per term", + "value": 1.2862677572105037 +} \ No newline at end of file diff --git a/interpro_family/paths.json b/interpro_family/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..97b07ca9180eb69c9431b9f11bf74368466c5b8d --- /dev/null +++ b/interpro_family/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/interpro_family/fragment/C220/C220_val_log2fc"} \ No newline at end of file diff --git a/interpro_family/result.tsv b/interpro_family/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..a4fed519853c418fc12ed880c22f1a1aee21148f --- /dev/null +++ b/interpro_family/result.tsv @@ -0,0 +1,142 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Mitochondrial carrier protein [IPR002067] 0.7682347056998522 2.9238394291656404 0.003457430455511 0.999679467666566 0.0891400107795509 13 Q9BQT8,Q9HC21,Q9UJS0,Q86VD7,P12236,Q6NUK1,Q9H936,O43808,P12235,P53007,P05141 11 +Syntaxin [IPR045242] 0.8052999185335394 2.304635403447291 0.0211870014404662 1.0 0.1003717080721485 7 Q12846,Q86Y82,Q13190,O60499,Q9UNK0 5 +P-type ATPase [IPR001757] 0.8174469518356344 2.063733772997012 0.039042965342845 1.0 0.1353683708827298 5 P35670,P05023,Q9HD20,P16615 4 +Eukaryotic porin/Tom40 [IPR027246] 0.862289562289575 1.966231617392919 0.0492718618059306 1.0 0.1562386105008757 4 P45880,P21796,Q9Y277 3 +Mitochondrial inner membrane translocase complex, subunit Tim17 [IPR005678] 0.9989905787348587 1.9595067597912208 0.050053469017254 1.0 0.1577669043786718 2 Q99595 1 +Major facilitator superfamily [IPR011701] 0.8592572824756937 1.9534028155550136 0.0507718828748677 1.0 0.1581006486840722 4 P53985,Q96ES6 2 +Tetraspanin, animals [IPR000301] 0.992261103633917 1.931290214515322 0.0534471728378314 1.0 0.162510186521312 2 O43657 1 +Mitochondrial carrier UCP-like [IPR002030] 0.985195154777928 1.9016145774124047 0.0572215607642996 1.0 0.1684736193351939 2 Q9UBX3 1 +Membrane insertase YidC/ALB3/OXA1/COX18 [IPR001708] 0.9794751009421266 1.8775565561469325 0.0604418535875139 1.0 0.1746348580644215 2 Q8N8Q8 1 +Palmitoyl protein thioesterase [IPR002472] 0.9747644683714682 1.857721476352143 0.0632085770714661 1.0 0.179449979451614 2 P50897 1 +Transmembrane protein GPR107/GPR108-like [IPR009637] 0.9673620457604312 1.8265125064801693 0.0677730991500789 1.0 0.1878722068324979 2 Q5VW38 1 +Transmembrane protein 126 [IPR009801] 0.9663526244952914 1.822253113245193 0.0684165888914627 1.0 0.1883077440697487 2 Q9H061 1 +Haem oxygenase [IPR002051] 0.9639973082099615 1.8123112424761223 0.0699381183961331 1.0 0.1902415094077486 2 P30519 1 +Haem oxygenase-like [IPR016053] 0.9639973082099615 1.8123112424761223 0.0699381183961331 1.0 0.1902415094077486 2 P30519 1 +AmpG-like permease/Acetyl-coenzyme A transporter 1 [IPR004752] 0.9562584118438772 1.7796137224900923 0.0751391988925413 1.0 0.198427695199569 2 Q96ES6 1 +Nucleobindin [IPR040250] 0.9559219380888312 1.7781910342555816 0.0753724849646606 1.0 0.198740388845524 2 P80303 1 +Short-chain dehydrogenase/reductase SDR [IPR002347] 0.5090713202282002 1.775085593419727 0.0758837553730533 1.0 0.198985507377598 18 Q8NBN7,Q8NBQ5,Q53GQ0,Q06136,Q3SXM5,P35270,Q9BY49,Q96LJ7 8 +Tetraspanin/Peripherin [IPR018499] 0.9596095590710167 1.7379756989008786 0.0822150958146266 1.0 0.2085033357593718 3 O60637,O43657 2 +Porin, eukaryotic type [IPR001925] 0.950521709861996 1.7020667978459243 0.0887428470994806 1.0 0.2169996145390458 3 P45880,P21796 2 +Cation efflux protein [IPR002524] 0.9377523553162888 1.7012464818771558 0.0888967128749222 1.0 0.2171472807659773 2 Q6NXT4 1 +Cytochrome P450 [IPR001128] 0.9286675639300144 1.6626958580221347 0.0963733317476052 1.0 0.2282112636592119 2 Q16850 1 +Cleft lip and palate transmembrane protein 1-like protein [IPR030434] 0.925975773889637 1.651264842020272 0.0986845079508222 1.0 0.23070129768109 2 O96005 1 +Cleft lip and palate transmembrane 1 [IPR008429] 0.925975773889637 1.651264842020272 0.0986845079508222 1.0 0.23070129768109 2 O96005 1 +Derlin [IPR007599] 0.9253028263795428 1.6484065182357908 0.0992692793443024 1.0 0.23152865051889 2 Q9GZP9 1 +CD36 family [IPR002159] 0.9148721399730854 1.6040760451081746 0.1086972914076445 1.0 0.2453875684547698 2 Q14108 1 +Transmembrane emp24 domain-containing protein [IPR015720] 0.6697566167573277 1.597093041784575 0.1102449690005455 1.0 0.2473352309421983 6 Q15363,P49755,Q9Y3B3 3 +Sulfotransferase [IPR005331] 0.9047779273216708 1.5611360546344557 0.1184916527155364 1.0 0.2584564406180198 2 Q8NCH0 1 +Mpv17/PMP22 [IPR007248] 0.9102996953612416 1.5424310551192917 0.1229688798636825 1.0 0.2644147869555508 3 Q567V2 1 +ADP/ATP carrier protein, eukaryotic type [IPR002113] 0.9040727027936676 1.5176341502993098 0.1291066527821853 1.0 0.2724245367970646 3 P12235,P12236 2 +V-type ATPase, V0 complex, 116kDa subunit family [IPR002490] 0.8893001345895072 1.4952465874304022 0.1348500991237262 1.0 0.2796935538075144 2 Q93050 1 +ATPase, V0 complex, subunit 116kDa, eukaryotic [IPR026028] 0.8893001345895072 1.4952465874304022 0.1348500991237262 1.0 0.2796935538075144 2 Q93050 1 +Importin subunit alpha [IPR024931] 0.745869765291504 1.4642024687297417 0.1431386359039252 1.0 0.2919741462306625 4 O00505 1 +Anoctamin [IPR007632] 0.8798788694481854 1.4551287896160154 0.145633610304285 1.0 0.2949493258385824 2 Q9NW15 1 +Proteasome B-type subunit [IPR023333] 0.6302156470542 1.454373753809473 0.1458427125228834 1.0 0.2951155236852422 7 P49721,P28070,P28072,P28074 4 +Protein-tyrosine phosphatase-like, PTPLA [IPR007482] 0.8795423956931414 1.453696043621553 0.1460305955683094 1.0 0.2952385322064254 2 Q9P035 1 +Membrane-associated, eicosanoid/glutathione metabolism (MAPEG) protein [IPR001129] 0.8792059219380897 1.452263305358476 0.14642840637678 1.0 0.2955283996639964 2 Q99735 1 +Graves disease carrier protein [IPR002167] 0.8768506056527583 1.4422344013160775 0.1492362588326072 1.0 0.2993746366737018 2 Q86VD7 1 +Membrane bound O-acyl transferase, MBOAT [IPR004299] 0.8835745567776733 1.4359046522556205 0.1510294745103761 1.0 0.3014101969824775 3 Q96N66 1 +Glycoside hydrolase, family 27 [IPR002241] 0.8691117092866761 1.409287592086054 0.1587501462533906 1.0 0.3117351188771495 2 P06280 1 +Nucleosome assembly protein (NAP) [IPR002164] 0.8714237630427369 1.387410155598069 0.1653167300106317 1.0 0.3206018899025585 3 Q01105,P55209 2 +TB2/DP1/HVA22-related protein [IPR004345] 0.8633916554508769 1.3849440025367985 0.1660695906855758 1.0 0.3207252161171424 2 Q9H6H4 1 +Small GTPase superfamily, ARF/SAR type [IPR006689] 0.6074482389611888 1.338942112127646 0.1805895187953536 1.0 0.3375053819053928 7 P18085,P40616,Q8N8L6 3 +Ergosterol biosynthesis ERG4/ERG24 [IPR001171] 0.8522880215343263 1.337721818554238 0.1809871357890031 1.0 0.3376911392116258 2 Q14739 1 +Ancient conserved domain protein family [IPR045095] 0.8512786002691802 1.3334316864477052 0.1823901797637956 1.0 0.3397693565287068 2 Q8NE01 1 +MICOS complex subunit MIC26/MIC27 [IPR019166] 0.8499327052489969 1.327712363207681 0.1842731477056227 1.0 0.3416768897184122 2 Q9BUR5 1 +MICOS complex subunit MIC26/MIC27, animal [IPR033182] 0.8499327052489969 1.327712363207681 0.1842731477056227 1.0 0.3416768897184122 2 Q9BUR5 1 +Acyl-CoA oxidase [IPR012258] 0.8452220726783359 1.3077030381033248 0.1909740524841048 1.0 0.349133745067324 2 Q15067 1 +Peroxisomal acyl-coenzyme A oxidase [IPR034171] 0.8452220726783359 1.3077030381033248 0.1909740524841048 1.0 0.349133745067324 2 Q15067 1 +Type 1 protein exporter [IPR039421] 0.8498821945472824 1.301428130710922 0.19311194992882 1.0 0.3512913544907197 3 O75027,Q03518 2 +Endoplasmic reticulum vesicle transporter [IPR045888] 0.8371467025572106 1.2734360996603584 0.2028633341858396 1.0 0.3641820133799889 2 Q9Y282 1 +Stomatin/HflK/HflC family [IPR001972] 0.8354643337819677 1.266303470558175 0.2054044549127387 1.0 0.3667598376343521 2 P27105 1 +Synthesis of cytochrome c oxidase, Sco1/Sco2 [IPR017276] 0.8341184387617826 1.2605990906830744 0.2074533264367892 1.0 0.3687177332155022 2 O43819 1 +Copper chaperone SCO1/SenC [IPR003782] 0.8341184387617826 1.2605990906830744 0.2074533264367892 1.0 0.3687177332155022 2 O43819 1 +Peptidase S10, serine carboxypeptidase [IPR001563] 0.8391114102995505 1.2584681372605744 0.2082225034049662 1.0 0.369519385339753 3 Q9HB40,P10619 2 +Lysosome-associated membrane glycoprotein [IPR002000] 0.8209959623149434 1.2050726959340272 0.2281752392941993 1.0 0.3925189466417548 2 P11279 1 +Chloride channel, voltage gated [IPR001807] 0.8176312247644686 1.1908655333989835 0.233706377113138 1.0 0.397728874750051 2 P51798 1 +TAF15/EWS/TLS family [IPR034870] 0.82093571188152 1.1860882756563127 0.2355874401292896 1.0 0.3997586730608765 3 Q92804,P35637 2 +Mitochondrial import inner membrane translocase subunit Tim8/13 [IPR039238] 0.8156123822341877 1.1823479672865476 0.2370676600356673 1.0 0.4013144155384832 2 Q9Y5J9 1 +Protein transport protein Sec23 [IPR037364] 0.8129205921938178 1.1709994794216054 0.241598986401476 1.0 0.4061030719324376 2 Q15437 1 +HnRNP R/Q splicing factor [IPR006535] 0.8058546433378206 1.141258025861391 0.2537625637383953 1.0 0.4189697480911815 2 O60506 1 +ATPase family AAA domain-containing protein 3 [IPR039188] 0.8041722745625886 1.134187761433091 0.2567157965830979 1.0 0.4224486781134184 2 Q9NVI7 1 +Nonaspanin (TM9SF) [IPR004240] 0.806799057556364 1.1299501560364915 0.2584972278774207 1.0 0.4237749190961525 3 Q9HD45,Q99805 2 +Torsin [IPR010448] 0.8028263795423983 1.1285347851218928 0.2590941348627771 1.0 0.4244539317956496 2 O14657 1 +Amyloidogenic glycoprotein [IPR008155] 0.7974427994616407 1.1059530069738566 0.2687468599125022 1.0 0.4337615759281764 2 Q06481 1 +Prenylated rab acceptor PRA1 [IPR004895] 0.7963648603163908 1.0886385872941142 0.2763132934458963 1.0 0.442672952189529 3 Q9UI14,O60831 2 +Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase [IPR001930] 0.6048575482337888 1.0804491708006578 0.279942209790841 1.0 0.4457201873503247 5 Q9NZ08,Q9UIQ6 2 +Prohibitin [IPR000163] 0.7860026917900399 1.058143079999438 0.2899902166182719 1.0 0.4552178547074426 2 P35232 1 +Tricarboxylate/iron carrier [IPR004686] 0.7886233591383351 1.0580721114144989 0.290022567786059 1.0 0.4552178547074426 3 Q6P4A7,Q96NB2 2 +SCAMP [IPR007273] 0.7875004446870881 1.053645076698333 0.292045443361753 1.0 0.4571573887664098 3 O15127 1 +Protein Yip1/4-like [IPR045231] 0.784656796769855 1.052535660838197 0.2925538582859985 1.0 0.4573368861361875 2 Q969M3 1 +Vacuolar protein sorting-associated protein 13 [IPR026847] 0.7823014804845208 1.0427320914852862 0.2970723904912085 1.0 0.4612962320261212 2 Q5THJ4 1 +Peptidase C13, legumain [IPR001096] 0.781965006729475 1.0413325785093934 0.2977212216594576 1.0 0.4615072415821151 2 Q92643 1 +Ribosomal protein S6 kinase II [IPR016239] 0.7678331090174999 0.982796385323028 0.3257076612438938 1.0 0.4892040323576144 2 P51812 1 +Glycoside hydrolase, family 29 [IPR000933] 0.766487213997317 0.9772481114045464 0.3284463347099189 1.0 0.4912948071675091 2 Q9BTY2 1 +Alpha-L-fucosidase, metazoa-type [IPR016286] 0.766487213997317 0.9772481114045464 0.3284463347099189 1.0 0.4912948071675091 2 Q9BTY2 1 +Arginine-tRNA ligase [IPR001278] 0.7627860026918003 0.9620162463087508 0.3360414431162457 1.0 0.4991203787461885 2 P54136 1 +Oligosaccharyl transferase, STT3 subunit [IPR003674] 0.7621130551817045 0.959250994452166 0.3374323164738517 1.0 0.5006935865876827 2 P46977 1 +Aminopeptidase N-type [IPR034016] 0.7616963985190037 0.952478344603334 0.3408544434135288 1.0 0.503372455212732 3 Q9NZ08,Q9UIQ6 2 +Flotillin family [IPR027705] 0.7526917900403827 0.9206803512981058 0.3572173375526417 1.0 0.5170422681971591 2 O75955 1 +Synaptobrevin [IPR001388] 0.7489905787348592 0.9056047211446232 0.3651451090228448 1.0 0.5237846525890832 2 O75396 1 +Tumour protein D52 [IPR007327] 0.7473082099596275 0.8987673954052954 0.3687765703054373 1.0 0.5265322512719919 2 P55327 1 +Bcl-2 family [IPR026298] 0.7451861125756709 0.8884523624942043 0.3742974697145418 1.0 0.5311502884220407 3 Q9BXK5 1 +Bcl2-like [IPR002475] 0.7451861125756709 0.8884523624942043 0.3742974697145418 1.0 0.5311502884220407 3 Q9BXK5 1 +Calcium uptake protein 1/2/3 [IPR039800] 0.7341857335127929 0.8457868771305557 0.397671647463008 1.0 0.5516317088434437 2 Q8IYU8 1 +Erlin1/2 [IPR033294] 0.7331763122476528 0.8417387409104586 0.3999342080937433 1.0 0.5530611655717066 2 O75477 1 +SUN domain-containing protein 1-5 [IPR045119] 0.7328398384925991 0.8403902743940481 0.4006896003689979 1.0 0.5530611655717066 2 Q9UH99 1 +Mitofusin family [IPR027094] 0.7257738896366117 0.8121810232061119 0.4166877668669684 1.0 0.5647407715472389 2 Q8IWA4 1 +Peptidase M3A/M3B [IPR045090] 0.6980814540558554 0.7102070621628236 0.477575742112627 1.0 0.6179099441789042 3 Q9BYT8,Q99797 2 +Sorting nexin-5/6/32 [IPR014637] 0.696837146702564 0.6991082228662299 0.4844844000714383 1.0 0.6212769489763879 2 Q9Y5X3 1 +Peptidase T1A, proteasome beta-subunit [IPR000243] 0.657691013126875 0.5649366825465187 0.5721168319555527 1.0 0.6862343370922538 3 P28072,P28074 2 +Serine hydroxymethyltransferase [IPR001085] 0.6554508748317676 0.5461297157331619 0.5849767747024133 1.0 0.6950241764518463 2 P34897 1 +Prefoldin beta-like [IPR002777] 0.6544414535666241 0.5425549805431206 0.5874362427294213 1.0 0.69623183258186 2 Q9UHV9 1 +NADH:cytochrome b5 reductase-like [IPR001834] 0.6453566621803539 0.5107636847925139 0.6095165408628616 1.0 0.7083076160202239 2 Q9UHQ9 1 +Molecular chaperone regulator BAG [IPR039773] 0.6443472409152127 0.5072748245289914 0.6119620004650217 1.0 0.7105628892472751 2 O95429 1 +NSF attachment protein [IPR000744] 0.633916554508753 0.4717575508928431 0.6370998533177565 1.0 0.7260340865791685 2 P54920 1 +A-kinase anchoring protein 95 (AKAP95) [IPR007071] 0.6183103332211268 0.4330749798011465 0.6649602989223153 1.0 0.7411092474043609 3 Q5BKZ1,O43823 2 +Vesicle-associated membrane-protein-associated protein [IPR016763] 0.6207940780619168 0.4285355981739766 0.6682612219902584 1.0 0.7431167155018527 2 Q9P0L0 1 +Prefoldin alpha-like [IPR004127] 0.609559071019845 0.4054055575075009 0.6851794265423563 1.0 0.7485124355916936 3 P61758,Q9UBK9 2 +Sodium/potassium-transporting ATPase subunit beta [IPR000402] 0.6133916554508807 0.404919952101319 0.6855363518661604 1.0 0.7485124355916936 2 P54709 1 +Heterogeneous nuclear ribonucleoprotein C [IPR017347] 0.5972409152086208 0.3554520361523479 0.7222509714009331 1.0 0.7694285443100009 2 P07910 1 +Adaptor protein complex, sigma subunit [IPR016635] 0.5873443285089063 0.3382736506848253 0.7351569782430454 1.0 0.7800027215050784 3 P56377,Q92572 2 +CTP synthase [IPR004468] 0.5605652759084883 0.2546819258224595 0.7989687771251219 1.0 0.8341593120277115 2 Q9NRF8 1 +Small GTPase superfamily, ARF type [IPR024156] 0.5501059904960529 0.237069952599595 0.8126025223125906 1.0 0.8468710898753468 3 P18085 1 +Exocyst complex component EXOC6/Sec15 [IPR007225] 0.5494616419919343 0.2276169176829696 0.8199440667495606 1.0 0.854139043524318 2 Q9Y2D4 1 +Mrp/NBP35 ATP-binding protein [IPR019591] 0.5360026917900466 0.1970856947486313 0.8437604778150729 1.0 0.875032199508789 2 Q8TB37 1 +Flagellum site-determining protein YlxH/ Fe-S cluster assembling factor NBP35 [IPR033756] 0.5360026917900466 0.1970856947486313 0.8437604778150729 1.0 0.875032199508789 2 Q8TB37 1 +Proteasome, subunit alpha/beta [IPR001353] 0.3159693868686009 0.1909955257920119 0.8485290985335205 1.0 0.8795774635847248 14 P49721,P28070 2 +Polyadenylate binding protein, human types 1, 2, 3, 4 [IPR006515] 0.5312920592193924 0.1869997633174304 0.8516608185174752 1.0 0.8824300095522278 2 Q13310 1 +Sulfurtransferase TST/MPST-like [IPR045078] 0.5302826379542508 0.1848793374447869 0.8533236779332543 1.0 0.8837587623000221 2 P25325 1 +U3 snoRNP protein/Ribosome production factor 1 [IPR044281] 0.5286002691790108 0.1813774152631357 0.856071344869848 1.0 0.8862093289361216 2 Q9H9Y2 1 +Chaperone DnaJ [IPR012724] 0.5260854930999512 0.1802914832522764 0.8569237414977733 1.0 0.8866965930954687 3 O60884,Q96EY1 2 +DnaJ homolog subfamily A member 1/2-like [IPR044713] 0.5259084791386389 0.1758579909853724 0.8604055092651053 1.0 0.8887158728425254 2 O60884 1 +Sec1-like protein [IPR001619] 0.4188552188552196 0.1612639016404865 0.8718855534081753 1.0 0.8989747627905864 4 O00186,Q96AX1,Q8WVM8 3 +S-phase kinase-associated protein 1-like [IPR001232] 0.5121130551817075 0.1491925787403026 0.8814016757643057 1.0 0.9067848379624522 2 Q15369 1 +Eukaryotic translation initiation factor 3 subunit M eIF3m/COP9 signalosome complex subunit 7 COPS7 [IPR045237] 0.5030282637954322 0.1331157494594124 0.8941018397276908 1.0 0.9186194487781626 2 Q9UBW8 1 +RuvB-like [IPR027238] 0.4962987886944955 0.1219628429528349 0.902928445557639 1.0 0.9256411204900244 2 Q9Y230 1 +SOUL haem-binding protein [IPR006917] 0.4939434724091564 0.118210315754385 0.905901016478836 1.0 0.9278695155557036 2 Q9Y5Z4 1 +Profilin1/2/3, vertebrate [IPR005454] 0.4929340511440145 0.1166259405537898 0.9071564804095728 1.0 0.9283367858993118 2 P35080 1 +Profilin [IPR005455] 0.4929340511440145 0.1166259405537898 0.9071564804095728 1.0 0.9283367858993118 2 P35080 1 +Tropomodulin [IPR004934] 0.4841857335127919 0.103489780466641 0.9175742599504038 1.0 0.9365224103096608 2 P28289 1 +Ribosomal protein S5/S7 [IPR000235] 0.4791386271870929 0.0963914941038583 0.9232096473897082 1.0 0.941446888009786 2 Q9Y2R9 1 +E3 ubiquitin ligase Bre1 [IPR013956] 0.4754374158815702 0.0914061603502678 0.9271698669917494 1.0 0.945070469952538 2 O75150 1 +Polyprenyl synthetase [IPR000092] 0.4724091520861374 0.0874641662049151 0.9303025674674876 1.0 0.9474322070262928 2 O95749 1 +Microtubule-associated protein RP/EB [IPR027328] 0.4680349932705308 0.0819850881222955 0.9346585714876544 1.0 0.951193758213486 2 Q15691 1 +HnRNP-L/PTB [IPR006536] 0.4735779198922841 0.0817883187982123 0.93481504520077 1.0 0.951193758213486 3 Q8WVV9,P14866 2 +Kinesin-like protein [IPR027640] 0.3366983203160119 0.0744552988695512 0.940648108728197 1.0 0.956027906097108 8 Q86Y91 1 +Malic oxidoreductase [IPR001891] 0.4576043068640729 0.0699220455081227 0.9442557062934394 1.0 0.9582813480645084 2 P48163 1 +FAM98 [IPR018797] 0.445827725437429 0.0579355524897383 0.953799963879096 1.0 0.9662788120763802 2 Q52LJ0 1 +Clathrin adaptor, mu subunit [IPR001392] 0.4564119824974646 0.0573576086406506 0.9542603307819256 1.0 0.96632377872991 3 Q96CW1,Q9Y2T2 2 +ClpA/B family [IPR001270] 0.4417900403768497 0.0542072439629115 0.9567700493244766 1.0 0.9684430608195028 2 Q9H078 1 +Pyrroline-5-carboxylate reductase [IPR000304] 0.4516997643890905 0.0513039684128228 0.9590833059348356 1.0 0.9699392771818124 3 Q53H96,Q96C36 2 +Ribosomal protein L15 [IPR030878] 0.4199192462987854 0.0371442122030426 0.970370020093466 1.0 0.979222222709436 2 Q9P015 1 +Ribosomal protein S11 [IPR001971] 0.4131897711978493 0.0328770720390328 0.9737726167719912 1.0 0.98137691486392 2 P82912 1 +Phosphatidylethanolamine-binding protein [IPR008914] 0.4047779273216698 0.0281297358176395 0.9775586776998691 1.0 0.983911962000345 2 P30086 1 +Phosphatidylethanolamine-binding protein, eukaryotic [IPR035810] 0.4047779273216698 0.0281297358176395 0.9775586776998691 1.0 0.983911962000345 2 P30086 1 +Glycerol-3-phosphate O-acyltransferase/Dihydroxyacetone phosphate acyltransferase [IPR022284] 0.3977119784656772 0.0246115524323411 0.980364804583141 1.0 0.986308982696681 2 O15228 1 +Alpha-catenin [IPR001033] 0.3943472409152081 0.0230775559727622 0.981588408657322 1.0 0.9871124992688132 2 Q9UBT7 1 +G-protein alpha subunit, group I [IPR001408] 0.3697846567967716 0.0143037066084367 0.9885876824886636 1.0 0.9934807661776102 2 P04899 1 +Kinesin light chain [IPR002151] 0.4160215415684885 0.0140671851957086 0.9887763802852496 1.0 0.9934807661776102 3 Q9H0B6,Q9NSK0 2 +cAMP-dependent protein kinase regulatory subunit [IPR012198] 0.3543068640645997 0.0105985171377972 0.9915437651214324 1.0 0.9954002447610576 2 P10644 1 +Ribonuclease CAF1 [IPR006941] 0.339165545087477 0.0080126524489118 0.9936068967289816 1.0 0.9970405274736176 2 O95453 1 diff --git a/interpro_family/selections.json b/interpro_family/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..062c7413277decdf8338d5ba7469cee705df54dc --- /dev/null +++ b/interpro_family/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["(Uracil-5)-methyltransferase family [IPR010280]", "-alpha-acetyltransferase 35, NatC auxiliary subunit [IPR007244]", "1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase, eukaryotes [IPR027496]", "1,4-alpha-glucan-branching enzyme [IPR037439]", "1-Cys peroxiredoxin [IPR045020]", "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [IPR028380]", "14-3-3 protein [IPR000308]", "14-3-3 theta [IPR042584]", "18S rRNA (guanine(1575)-N(7))-methyltransferase Bud23-like [IPR039769]", "2-amino-3-ketobutyrate coenzyme A ligase [IPR011282]", "2-deoxynucleoside 5-phosphate N-hydrolase 1, DNPH1 [IPR028607]", "2-oxoglutarate dehydrogenase E1 component [IPR011603]", "2-phosphoglycolate phosphatase, eukaryotic [IPR006349]", "26S Proteasome non-ATPase regulatory subunit 1 [IPR035266]", "26S Proteasome non-ATPase regulatory subunit 11 [IPR035295]", "26S Proteasome non-ATPase regulatory subunit 12 [IPR035297]", "26S Proteasome non-ATPase regulatory subunit 12/COP9 signalosome complex subunit 4 [IPR040134]", "26S Proteasome non-ATPase regulatory subunit 13 [IPR035298]", "26S Proteasome non-ATPase regulatory subunit 14 [IPR035299]", "26S Proteasome non-ATPase regulatory subunit 6 [IPR035268]", "26S Proteasome non-ATPase regulatory subunit 7/8 [IPR033858]", "26S Proteasome non-ATPase regulatory subunit 9 [IPR035269]", "26S Proteasome regulatory subunit 4 [IPR035244]", "26S Proteasome regulatory subunit 6A [IPR035254]", "26S Proteasome regulatory subunit 6B [IPR035256]", "26S Proteasome regulatory subunit 7 [IPR035245]", "26S proteasome non-ATPase regulatory subunit 10-like [IPR039334]", "26S proteasome non-ATPase regulatory subunit 3 [IPR035267]", "26S proteasome non-ATPase regulatory subunit Rpn12 [IPR006746]", "26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit [IPR016643]", "26S proteasome regulatory complex, non-ATPase subcomplex, Rpn2/Psmd1 subunit [IPR016642]", "26S proteasome regulatory subunit 10B [IPR035263]", "26S proteasome regulatory subunit P45-like [IPR005937]", "26S proteasome regulatory subunit Rpn7/COP9 signalosome complex subunit 1 [IPR019585]", "28S ribosomal protein S25, mitochondrial [IPR040049]", "28S ribosomal protein S27, mitochondrial [IPR019266]", "28kDa heat- and acid-stable phosphoprotein [IPR039876]", "3'-5' RNA helicase YTHDC2-like [IPR031083]", "3-hydroxyacyl-CoA dehydrogenase [IPR022694]", "3-hydroxyisobutyrate dehydrogenase [IPR011548]", "3-hydroxyisobutyrate dehydrogenase-related [IPR015815]", "3-ketodihydrosphingosine reductase KDSR-like [IPR045022]", "3-oxo-5-alpha-steroid 4-dehydrogenase/very-long-chain enoyl-CoA reductase [IPR039357]", "3-oxoacid CoA-transferase [IPR014388]", "39S ribosomal protein L40, mitochondrial [IPR039145]", "39S ribosomal protein L46, mitochondrial [IPR040008]", "40S Ribosomal protein S10 [IPR037447]", "40S ribosomal protein S1/3, eukaryotes [IPR027500]", "40S ribosomal protein S29/30S ribosomal protein S14 type Z [IPR039744]", "40S ribosomal protein SA [IPR027504]", "4F2 cell-surface antigen heavy chain [IPR042280]", "5'-3' exoribonuclease [IPR027073]", "5'-3' exoribonuclease type 2 [IPR017151]", "5'-AMP-activated protein kinase subunit gamma-1 [IPR039166]", "5-lipoxygenase-activating protein [IPR001446]", "50S ribosomal protein L18Ae/60S ribosomal protein L20 and L18a [IPR028877]", "6-Phosphogluconolactonase [IPR039104]", "6-phosphogluconate dehydrogenase [IPR006183]", "6-phosphogluconate dehydrogenase, decarboxylating [IPR006113]", "60S acidic ribosomal protein P0 [IPR030670]", "60S ribosomal protein L18a/ L20, eukaryotes [IPR021138]", "60S ribosomal protein L19 [IPR039547]", "60S ribosomal protein L35 [IPR045059]", "60S ribosomal protein L6E [IPR000915]", "60kDa SS-A/Ro ribonucleoprotein [IPR040322]", "A-kinase anchor protein 12 [IPR028540]", "A-kinase anchor protein 13 [IPR028852]", "A-kinase anchoring protein 95 (AKAP95) [IPR007071]", "A1 cistron-splicing factor, AAR2 [IPR007946]", "AAA ATPase, CDC48 family [IPR005938]", "ABC transporter Tap-like [IPR013305]", "ABI family [IPR028457]", "ADF/Cofilin [IPR017904]", "ADP-ribose pyrophosphatase, mitochondrial [IPR039989]", "ADP-ribosylation factor 1-5 [IPR045872]", "ADP-ribosylation factor 6 [IPR041838]", "ADP-ribosylation factor-like protein 10 [IPR042951]", "ADP-ribosylation factor-like protein 2 [IPR045873]", "ADP-ribosylation factor-like protein 2/3 [IPR044612]", "ADP-ribosylation factor-like protein 6-interacting protein 1 [IPR033301]", "ADP-ribosylation factor-like protein 6-interacting protein 6 [IPR029383]", "ADP-ribosylation/Crystallin J1 [IPR005502]", "ADP-specific phosphofructokinase/glucokinase [IPR007666]", "ADP/ATP carrier protein, eukaryotic type [IPR002113]", "AH receptor-interacting protein [IPR031208]", "AIP/AIPL1 [IPR039663]", "ALG11 mannosyltransferase [IPR038013]", "AP complex subunit beta [IPR026739]", "AP endonuclease 1 [IPR004808]", "AP-1 complex subunit sigma [IPR044733]", "AP-1/2/4 complex subunit beta [IPR016342]", "AP-2 complex subunit sigma [IPR027156]", "AP-3 complex subunit beta [IPR026740]", "AP-3 complex subunit sigma [IPR027155]", "ARMET-like [IPR045333]", "AT-rich interactive domain-containing protein 3 [IPR045147]", "ATP synthase, F0 complex, subunit A [IPR000568]", "ATP synthase, F0 complex, subunit A, bacterial/mitochondria [IPR045083]", "ATP synthase, F0 complex, subunit B [IPR013837]", "ATP synthase, F0 complex, subunit B/MI25 [IPR008688]", "ATP synthase, F0 complex, subunit D, mitochondrial [IPR008689]", "ATP synthase, F0 complex, subunit E, mitochondrial [IPR008386]", "ATP synthase, F0 complex, subunit G, mitochondrial [IPR006808]", "ATP synthase, F1 complex, alpha subunit [IPR005294]", "ATP synthase, F1 complex, beta subunit [IPR005722]", "ATP synthase, F1 complex, gamma subunit [IPR000131]", "ATP-citrate synthase [IPR014608]", "ATP-dependent 6-phosphofructokinase [IPR022953]", "ATP-dependent 6-phosphofructokinase, eukaryotic-type [IPR009161]", "ATP-dependent 6-phosphofructokinase, vertebrate-type [IPR041914]", "ATP-dependent Clp protease proteolytic subunit [IPR001907]", "ATP-dependent RNA helicase DHX29 [IPR034730]", "ATP-dependent RNA helicase Ski2-like [IPR016438]", "ATP-dependent helicase Rad3/Chl1-like [IPR013020]", "ATP11 [IPR010591]", "ATP:cob(I)alamin adenosyltransferase, PduO-type [IPR029499]", "ATP:guanido phosphotransferase [IPR000749]", "ATPase family AAA domain-containing protein 2 [IPR031252]", "ATPase family AAA domain-containing protein 3 [IPR039188]", "ATPase family AAA domain-containing protein ATAD2-like [IPR045199]", "ATPase, OSCP/delta subunit [IPR000711]", "ATPase, V0 complex, c/d subunit [IPR002843]", "ATPase, V0 complex, subunit 116kDa, eukaryotic [IPR026028]", "ATPase, V0 complex, subunit d [IPR016727]", "ATPase, V1 complex, subunit A [IPR005725]", "ATPase, V1 complex, subunit B [IPR005723]", "ATPase, V1 complex, subunit C [IPR004907]", "ATPase, V1 complex, subunit D [IPR002699]", "ATPase, V1 complex, subunit H [IPR004908]", "ATPase, vacuolar ER assembly factor, Vma12 [IPR021013]", "ATR-interacting protein [IPR033349]", "Abl interactor 1 [IPR028456]", "Acetyl-coenzyme A transporter 1-like [IPR024371]", "Acid ceramidase-like [IPR016699]", "Acidic leucine-rich nuclear phosphoprotein 32 [IPR045081]", "Acireductone dioxygenase ARD family [IPR004313]", "Aconitase, mitochondrial-like [IPR006248]", "Aconitase/Iron-responsive element-binding protein 2 [IPR006249]", "Actin family [IPR004000]", "Actin-related protein 10 [IPR027127]", "Actin-related protein 2/3 complex subunit 1 [IPR017383]", "Actin-related protein 2/3 complex subunit 1A [IPR030140]", "Actin-related protein 2/3 complex subunit 2 [IPR007188]", "Actin-related protein 2/3 complex subunit 3 [IPR007204]", "Actin-related protein 2/3 complex subunit 4 [IPR008384]", "Actin-related protein 2/3 complex subunit 5 [IPR006789]", "Actin-related protein 3 [IPR015623]", "Activator of 90kDa heat shock protein ATPase-like [IPR039981]", "Activator of Hsp90 ATPase homologue 1-like [IPR013538]", "Active zone protein ELKS [IPR019323]", "Activity-dependent neuroprotector homeobox protein [IPR038861]", "Acyl-CoA desaturase [IPR015876]", "Acyl-CoA oxidase [IPR012258]", "Acyl-CoA-binding domain-containing protein 5 [IPR016347]", "Acyl-coenzyme A thioesterase 13 [IPR039298]", "Acylneuraminate cytidylyltransferase [IPR003329]", "Acyltransferase ChoActase/COT/CPT [IPR000542]", "Adaptor protein complex AP-1, gamma subunit [IPR017107]", "Adaptor protein complex AP-2, alpha subunit [IPR017104]", "Adaptor protein complex AP-3, delta subunit [IPR017105]", "Adaptor protein complex, sigma subunit [IPR016635]", "Adenine phosphoribosyl transferase [IPR005764]", "Adenosylhomocysteinase-like [IPR000043]", "Adenylate cyclase-associated CAP [IPR001837]", "Adenylate kinase 2 [IPR028587]", "Adenylate kinase isoenzyme 1 [IPR028582]", "Adenylate kinase subfamily [IPR006259]", "Adenylate kinase, isozyme 1/5 [IPR006267]", "Adenylate kinase/UMP-CMP kinase [IPR000850]", "Adenylosuccinate lyase [IPR004769]", "Adenylosuccinate synthetase [IPR001114]", "Adenylosuccinate synthetase isozyme 2, chordates [IPR027529]", "Adenylyl cyclase-associated protein CAP1 [IPR028415]", "AdoMet-dependent rRNA methyltransferase Spb1-like [IPR028589]", "Aladin [IPR045139]", "Alanine-tRNA ligase, class IIc [IPR002318]", "Alanine-tRNA ligase, eukaryota/bacteria [IPR023033]", "Alcohol dehydrogenase class III [IPR014183]", "Aldehyde dehydrogenase NAD(P)-dependent [IPR012394]", "Aldehyde dehydrogenase family 7 member A1-like [IPR044638]", "Aldo-keto reductase [IPR020471]", "Aldo-keto reductase family 1 member A1 [IPR044481]", "Alkyldihydroxyacetonephosphate synthase [IPR025650]", "Alpha E-catenin/Alpha T-catenin [IPR030047]", "Alpha crystallin/Small heat shock protein, animal type [IPR001436]", "Alpha-2-macroglobulin receptor-associated protein [IPR038003]", "Alpha-D-phosphohexomutase superfamily [IPR005841]", "Alpha-L-fucosidase, metazoa-type [IPR016286]", "Alpha-N-acetylglucosaminidase [IPR007781]", "Alpha-N-methyltransferase NTM1 [IPR008576]", "Alpha-adducin [IPR027766]", "Alpha-catenin [IPR001033]", "Alpha-catulin 1 [IPR030045]", "Alpha-internexin [IPR027703]", "Alpha-ketoglutarate-dependent dioxygenase FTO [IPR032868]", "Amidase [IPR000120]", "Amidophosphoribosyltransferase [IPR005854]", "Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 [IPR042360]", "Aminoacyl-tRNA synthetase, class Ic [IPR002305]", "Aminopeptidase N-type [IPR034016]", "Aminopeptidase, leukotriene A4 hydrolase-like [IPR034015]", "Aminotransferase ALAT1/2-like [IPR045088]", "Aminotransferase class-III [IPR005814]", "AmpG-like permease/Acetyl-coenzyme A transporter 1 [IPR004752]", "Amyloid-beta precursor protein [IPR028866]", "Amyloidogenic glycoprotein [IPR008155]", "Anamorsin [IPR007785]", "Anaphase-promoting complex subunit 1 [IPR024990]", "Anaphase-promoting complex subunit 16 [IPR029641]", "Anaphase-promoting complex subunit 2 [IPR044554]", "Anaphase-promoting complex subunit 5 [IPR037679]", "Ancient conserved domain protein family [IPR045095]", "Angiomotin [IPR009114]", "Ankycorbin [IPR042420]", "Ankyrin repeat and LEM domain-containing protein 2 [IPR035007]", "Annexin A1 [IPR002388]", "Annexin A11 [IPR008157]", "Annexin A2 [IPR002389]", "Annexin A3 [IPR002390]", "Annexin A4 [IPR002391]", "Annexin A6 [IPR002393]", "Annexin [IPR001464]", "Anoctamin [IPR007632]", "Anoctamin-10 [IPR031291]", "Anoctamin-6 [IPR031295]", "Antifreeze, type III [IPR006013]", "Antigen peptide transporter 1 [IPR013306]", "Apolipoprotein L [IPR008405]", "Apoptosis inhibitory 5 [IPR008383]", "Apoptosis regulator BAK [IPR026308]", "Apoptosis regulator, Mcl-1 [IPR013281]", "Archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit [IPR006111]", "Arfaptin family [IPR030798]", "Arfaptin-1 [IPR030793]", "Arginine and glutamate-rich protein 1 [IPR033371]", "Arginine-tRNA ligase [IPR001278]", "Arginine-tRNA-protein transferase 1, eukaryotic [IPR017137]", "Armadillo repeat-containing protein 6 [IPR040104]", "Armadillo-type fold containing protein ARMC8/Vid28 [IPR038739]", "Arsenical pump ATPase, ArsA/GET3 [IPR016300]", "Arsenical pump ATPase, ArsA/GET3, eukaryotic [IPR027542]", "Arylesterase [IPR002640]", "Asparagine synthase, glutamine-hydrolyzing [IPR006426]", "Asparagine-tRNA ligase [IPR004522]", "Asparaginyl endopeptidase [IPR043577]", "Aspartate carbamoyltransferase [IPR002082]", "Aspartate-tRNA ligase, type 1 [IPR004524]", "Aspartate-tRNA synthetase, type 2 [IPR004523]", "Aspartate/ornithine carbamoyltransferase [IPR006130]", "Aspartate/other aminotransferase [IPR000796]", "Aspartyl/Asparaginyl-tRNA synthetase, class IIb [IPR002312]", "Aspartyl/asparaginyl beta-hydroxylase family [IPR039038]", "Associate of Myc 1 [IPR026060]", "Ataxin2-like [IPR045117]", "Atypical dual specificity phosphatase, subfamily A [IPR020405]", "Atypical kinase COQ8A [IPR034640]", "Aurora kinase B [IPR028772]", "Aurora kinase [IPR030616]", "Autophagy protein Atg8 ubiquitin-like [IPR004241]", "Autophagy-related protein 9 [IPR007241]", "B-cell receptor-associated protein 29/31 [IPR008417]", "BAG family molecular chaperone regulator 2 [IPR037689]", "BBP/SF1 family [IPR031150]", "BCP1 family [IPR025602]", "BLOC-2 complex, Hps6 subunit [IPR017218]", "BRCA1-associated ATM activator 1 [IPR038904]", "BRI3-binding protein [IPR033367]", "BRISC and BRCA1-A complex member 1 [IPR026126]", "Bacterial/eukaryotic lysine-tRNA ligase, class II [IPR034762]", "Baculoviral IAP repeat-containing protein 6 [IPR022103]", "Band 4.1 protein, chordates [IPR021187]", "Band 4.1-like protein 2 [IPR030546]", "Band 4.1-like protein 3 [IPR030691]", "Band 4.1-like protein 5 [IPR030694]", "Band-7 stomatin-like [IPR043202]", "Barrier- to-autointegration factor, BAF [IPR004122]", "Basigin [IPR044157]", "Basigin-like [IPR043204]", "Bax inhibitor 1-related [IPR006214]", "Bcl-2 family [IPR026298]", "Bcl-2-associated transcription factor 1 [IPR026668]", "Bcl-2-like protein 13 [IPR042398]", "Bcl2-like [IPR002475]", "Beta tubulin [IPR002453]", "Beta-1,4-glucuronyltransferase 1 [IPR043189]", "Beta-N-acetylglucosaminidase [IPR011496]", "Beta-catenin [IPR013284]", "Beta-catenin-like protein 1 [IPR039678]", "Beta-galactosidase 1-like [IPR026283]", "Beta-hexosaminidase [IPR025705]", "Beta-lactamase HcpB-like [IPR040239]", "Bicarbonate transporter, eukaryotic [IPR003020]", "Bicaudal-D protein [IPR018477]", "Bifunctional polynucleotide phosphatase/kinase PNKP [IPR006550]", "Bifunctional purine biosynthesis protein PurH-like [IPR002695]", "Biliverdin reductase A [IPR017094]", "Biorientation of chromosomes in cell division protein 1-like [IPR026955]", "BolA protein [IPR002634]", "BolA-like protein 2 [IPR045115]", "Brain acid soluble protein 1 [IPR008408]", "Bystin [IPR007955]", "C-5 cytosine methyltransferase [IPR001525]", "C-terminal binding protein [IPR043322]", "C2 domain-containing protein 5 [IPR038983]", "CAAX prenyl protease 1 [IPR027057]", "CCR4-NOT transcription complex subunit 1 [IPR040398]", "CCR4-NOT transcription complex subunit 10 [IPR039740]", "CCR4-NOT transcription complex subunit 11 [IPR019312]", "CCR4-NOT transcription complex subunit 9 [IPR007216]", "CD2 antigen cytoplasmic tail-binding protein 2/Lin1 [IPR039905]", "CD2-associated protein [IPR028445]", "CD34/Podocalyxin [IPR013836]", "CD36 family [IPR002159]", "CD36/scavenger receptor class B member 1 [IPR005428]", "CDC50/LEM3 family [IPR005045]", "CDGSH iron-sulfur domain-containing protein 1/2 [IPR045131]", "CDK2-associated and cullin domain-containing protein 1 [IPR042652]", "CDK5 regulatory subunit-associated protein 3 [IPR008491]", "CDP-alcohol phosphatidyltransferase [IPR000462]", "CDP-diacylglycerol-inositol 3-phosphatidyltransferase, eukaryote [IPR014387]", "CEBPZ/Mak21-like [IPR040155]", "CHORD domain containing protein [IPR039790]", "CLIP-associating protein 1 [IPR028399]", "CLU domain containing protein [IPR027523]", "COMM domain-containing protein 1 [IPR037351]", "COMPASS component Swd2/WDR82 [IPR037867]", "COP9 Signalosome complex subunit 7A [IPR037757]", "COP9 signalosome complex subunit 1 [IPR033008]", "COP9 signalosome complex subunit 2 [IPR037750]", "COP9 signalosome complex subunit 3 [IPR037753]", "COP9 signalosome complex subunit 4 [IPR037754]", "COP9 signalosome complex subunit 5 [IPR037740]", "COP9 signalosome subunit 6 [IPR033859]", "COP9 signalosome, subunit CSN8 [IPR033205]", "COPII coat assembly protein, Sec16 [IPR024880]", "CPSF6/7 family [IPR034772]", "CTP synthase [IPR004468]", "CWF11 family [IPR026300]", "CYFIP-related Rac1 interactor [IPR039789]", "Cadherin [IPR039808]", "Calcium homeostasis endoplasmic reticulum protein [IPR039037]", "Calcium load-activated calcium channel [IPR008559]", "Calcium uptake protein 1/2/3 [IPR039800]", "Calcium-binding mitochondrial carrier protein Aralar2 [IPR029658]", "Calcium-binding protein CAB45 [IPR027240]", "Caldesmon [IPR006017]", "Caldesmon/lymphocyte specific protein [IPR006018]", "Calpain-1 [IPR029643]", "Calpain-2 [IPR029539]", "Calpastatin [IPR026998]", "Calponin/LIMCH1 [IPR001997]", "Calreticulin [IPR009169]", "Calreticulin/calnexin [IPR001580]", "Calumenin [IPR027239]", "Cap-specific mRNA (nucleoside-2-O-)-methyltransferase 1 [IPR030376]", "Caprin [IPR028816]", "Carbamoyl-phosphate synthase, large subunit [IPR006275]", "Carbamoyl-phosphate synthase, small subunit [IPR006274]", "Carbohydrate sulfotransferase 8-10 [IPR018011]", "Cartilage-associated protein [IPR033212]", "Casein Kinase 2, subunit alpha [IPR045216]", "Casein kinase II, regulatory subunit [IPR000704]", "Cat eye syndrome critical region protein 2 [IPR029614]", "Cat eye syndrome critical region protein 5 [IPR029621]", "Catechol O-methyltransferase, eukaryotic [IPR017128]", "Catenin delta-1 [IPR028439]", "Cation efflux protein [IPR002524]", "Cation-dependent mannose-6-phosphate receptor [IPR000296]", "Cdc37 [IPR004918]", "Cdc42 [IPR037874]", "Cdc73/Parafibromin [IPR007852]", "Cell cycle and apoptosis regulator protein 2 [IPR028811]", "Cell cycle and apoptosis regulator protein [IPR025224]", "Cell cycle checkpoint, Hus1 [IPR016580]", "Cell cycle control protein 50A [IPR030351]", "Cell division cycle protein 123 [IPR009772]", "Cell division cycle-associated protein 2 [IPR033064]", "Cell division protein borealin [IPR018867]", "Cell growth-regulating nucleolar protein [IPR039999]", "Cell-cycle alteration and expression-elevated protein in tumour [IPR032337]", "Centrin 2 [IPR037629]", "Centromere protein I [IPR012485]", "Centromere protein P [IPR027801]", "Centrosomal protein of 290kDa [IPR026201]", "Centrosomal protein of 44kDa [IPR033603]", "Centrosomal protein of 55kDa [IPR038926]", "Ceramide glucosyltransferase [IPR025993]", "Ceroid-lipofuscinosis neuronal protein 5 [IPR026138]", "Cgr1-like [IPR005579]", "Chaperone DnaJ [IPR012724]", "Chaperone DnaK [IPR012725]", "Chaperone tailless complex polypeptide 1 (TCP-1) [IPR017998]", "Chaperonin Cpn60/GroEL [IPR001844]", "Chaperonin Cpn60/GroEL/TCP-1 family [IPR002423]", "Charged multivesicular body protein 1a [IPR029888]", "Checkpoint protein Hus1/Mec3 [IPR007150]", "Chitobiosyldiphosphodolichol beta-mannosyltransferase ALG1-like [IPR026051]", "Chloride channel CLIC-like [IPR009231]", "Chloride channel ClC-3 [IPR002245]", "Chloride channel ClC-7 [IPR002249]", "Chloride channel, voltage gated [IPR001807]", "Chloride intracellular channel protein 1 [IPR030259]", "Chloride intracellular channel protein 4/6 [IPR030257]", "Chromatid cohesion factor MAU2 [IPR019440]", "Chromatin assembly factor 1 subunit A [IPR022043]", "Chromatin assembly factor 1 subunit Cac2/CHAF1B/FAS2 [IPR045145]", "Chromatin-remodeling complex component Sfh1/SNF5 [IPR017393]", "Chromobox protein homologue 3 [IPR038033]", "Chromodomain-helicase-DNA-binding protein 1-like [IPR031053]", "Chromosome alignment-maintaining phosphoprotein 1 [IPR039330]", "Cilia- and flagella-associated protein 20/CFAP20DC [IPR040441]", "Cilia- and flagella-associated protein 298 [IPR021298]", "Citrate synthase [IPR002020]", "Citrate synthase, eukaryotic-type [IPR010109]", "Class I-like SAM-dependent O-methyltransferase [IPR002935]", "Clathrin adaptor, mu subunit [IPR001392]", "Clathrin coat assembly protein AP180-like [IPR045192]", "Clathrin interactor 1 [IPR030544]", "Clathrin light chain [IPR000996]", "Clathrin, heavy chain [IPR016341]", "Cleavage and polyadenylation specificity factor subunit 2 [IPR027075]", "Cleavage and polyadenylation specificity factor subunit 6 [IPR034769]", "Cleavage and polyadenylation specificity factor subunit 7 [IPR034770]", "Cleavage stimulation factor subunit 2 [IPR033105]", "Cleavage/polyadenylation specificity factor subunit 5 [IPR016706]", "Cleft lip and palate transmembrane 1 [IPR008429]", "Cleft lip and palate transmembrane protein 1-like protein [IPR030434]", "Clp protease proteolytic subunit /Translocation-enhancing protein TepA [IPR023562]", "Clp protease, ATP-binding subunit ClpX [IPR004487]", "ClpA/B family [IPR001270]", "Clusterin [IPR016016]", "Clusterin-like [IPR000753]", "Co-chaperone protein p23-like [IPR045250]", "Coactosin-like protein [IPR030502]", "Coatomer alpha subunit [IPR016391]", "Coatomer beta subunit (COPB1) [IPR016460]", "Coatomer beta' subunit (COPB2) [IPR016453]", "Coatomer delta subunit [IPR027059]", "Coatomer gamma subunit [IPR017106]", "Coatomer subunit zeta [IPR039652]", "Coatomer, epsilon subunit [IPR006822]", "Cobalamin-dependent methionine synthase [IPR011822]", "Coenzyme A transferase family I [IPR004165]", "Cofilin 1 [IPR027234]", "Cohesin subunit Scc3/SA [IPR039662]", "Coiled-coil domain-containing protein 124/Oxs1 [IPR010422]", "Coiled-coil domain-containing protein 134 [IPR026321]", "Coiled-coil domain-containing protein 138 [IPR038798]", "Coiled-coil domain-containing protein 22 [IPR008530]", "Coiled-coil domain-containing protein 86 [IPR026570]", "Coiled-coil domain-containing protein 90-like [IPR024461]", "Coilin [IPR024822]", "Condensin complex subunit 2/barren [IPR022816]", "Condensin complex subunit 3 [IPR027165]", "Condensin subunit 1 [IPR007673]", "Condensin subunit 1/Condensin-2 complex subunit D3 [IPR026971]", "Condensin-2 complex subunit D3 [IPR012371]", "Condensin-2 complex subunit G2 [IPR024741]", "Conserved oligomeric Golgi complex, subunit 3 [IPR007265]", "Copine [IPR045052]", "Copper chaperone SCO1/SenC [IPR003782]", "Coproporphyrinogen III oxidase, aerobic [IPR001260]", "Core histone macro-H2A [IPR021171]", "Coronin 1B [IPR027340]", "Coronin 1C [IPR027333]", "Coronin 7 [IPR027331]", "Coronin [IPR015505]", "Cortactin [IPR015503]", "Csn12 family [IPR045114]", "Cullin [IPR045093]", "Cullin-4B [IPR033044]", "Cullin-associated NEDD8-dissociated protein 1/2 [IPR039852]", "Cwf19-like protein [IPR040194]", "Cyclic nucleotide phosphodiesterase [IPR008431]", "Cyclin [IPR039361]", "Cyclin-dependent kinase 6 [IPR028788]", "Cyclophilin-RNA interacting protein [IPR035542]", "Cyclophilin-type peptidyl-prolyl cis-trans isomerase [IPR024936]", "Cyclophilin-type peptidyl-prolyl cis-trans isomerase, cyclophilin A-like [IPR044666]", "Cysteine protease ATG4B, metazoa [IPR032916]", "Cysteine-tRNA ligase [IPR015803]", "Cysteinyl-tRNA synthetase/mycothiol ligase [IPR024909]", "Cystinyl aminopeptidase [IPR034017]", "Cytochrome B561-related [IPR019176]", "Cytochrome P450 [IPR001128]", "Cytochrome P450, E-class, group I [IPR002401]", "Cytochrome P450, E-class, group IV [IPR002403]", "Cytochrome b-c1 complex subunit 7 [IPR003197]", "Cytochrome b-c1 complex subunit 8 [IPR004205]", "Cytochrome b-c1 complex subunit 9 [IPR008027]", "Cytochrome c oxidase assembly factor 3, mitochondrial [IPR041752]", "Cytochrome c oxidase subunit 6C [IPR004204]", "Cytochrome c oxidase subunit IV [IPR013288]", "Cytochrome c oxidase subunit IV family [IPR004203]", "Cytochrome c oxidase subunit VII [IPR039297]", "Cytochrome c oxidase subunit VIIa, metazoa [IPR003177]", "Cytochrome c oxidase, subunit Va/VI [IPR003204]", "Cytochrome c oxidase, subunit Vb [IPR002124]", "Cytochrome c/quinol oxidase subunit II [IPR045187]", "Cytochrome c1 [IPR002326]", "Cytoplasmic FMR1-interacting [IPR008081]", "Cytoplasmic dynein 1 intermediate chain 1/2 [IPR025956]", "Cytoskeleton-associated protein 2 family [IPR026165]", "Cytoskeleton-associated protein 4 [IPR028428]", "Cytosolic Fe-S cluster assembly factor NUBP2/Cfd1, eukaryotes [IPR028600]", "Cytosolic acyl coenzyme A thioester hydrolase [IPR040170]", "Cytosolic nonspecific dipeptidase/DUG1 [IPR017153]", "Cytospin-A [IPR040166]", "D-3-phosphoglycerate dehydrogenase [IPR006236]", "DAD/Ost2 [IPR003038]", "DDB1- and CUL4-associated factor 16 [IPR028216]", "DDRGK domain containing protein [IPR019153]", "DDX54/DBP10 family [IPR033517]", "DENR family, eukaryotes [IPR005873]", "DNA (cytosine-5)-methyltransferase 1-like [IPR017198]", "DNA damage-binding protein 1 [IPR031297]", "DNA double-strand break repair protein Mre11 [IPR003701]", "DNA fragmentation factor 45 [IPR017299]", "DNA helicase, ATP-dependent, RecQ type [IPR004589]", "DNA ligase, ATP-dependent [IPR000977]", "DNA mismatch repair Msh2-type [IPR011184]", "DNA mismatch repair MutS family [IPR045076]", "DNA mismatch repair protein Msh2 [IPR032642]", "DNA mismatch repair protein MutS/MSH [IPR017261]", "DNA polymerase V/Myb-binding protein 1A [IPR007015]", "DNA polymerase alpha, subunit B [IPR016722]", "DNA polymerase delta subunit 3 [IPR019038]", "DNA polymerase delta/II small subunit family [IPR024826]", "DNA polymerase epsilon catalytic subunit [IPR029703]", "DNA primase large subunit, eukaryotic/archaeal [IPR007238]", "DNA primase, large subunit, eukaryotic [IPR016558]", "DNA primase, small subunit [IPR002755]", "DNA primase, small subunit, eukaryotic/archaeal [IPR014052]", "DNA repair protein Rad50, eukaryotes [IPR004584]", "DNA repair/transcription protein MET18/MMS19 [IPR039920]", "DNA replication complex GINS protein Psf2 [IPR007257]", "DNA replication licensing factor Mcm2 [IPR008045]", "DNA replication licensing factor Mcm3 [IPR008046]", "DNA replication licensing factor Mcm5 [IPR008048]", "DNA replication licensing factor Mcm6 [IPR008049]", "DNA replication licensing factor Mcm7 [IPR008050]", "DNA topoisomerase I [IPR001631]", "DNA topoisomerase II, eukaryotic-type [IPR001154]", "DNA topoisomerase II-beta [IPR028467]", "DNA topoisomerase, type IIA [IPR001241]", "DNA-directed DNA polymerase, family B [IPR006172]", "DNA-directed RNA pol I, largest subunit [IPR015699]", "DNA-directed RNA polymerase II subunit Rpb4-like [IPR045222]", "DNA-directed RNA polymerase III subunit RPC3 [IPR039748]", "DNA-directed RNA polymerase subunit RPABC5/Rpb10 [IPR000268]", "DNA-directed RNA polymerase subunit Rpo5/Rpb5 [IPR014381]", "DNA-directed RNA polymerase, phage-type [IPR002092]", "DNA-directed RNA polymerase, subunit RPB6 [IPR028363]", "DNA-directed RNA polymerase, subunit 2 [IPR015712]", "DNA-directed RNA polymerase, subunit beta-prime [IPR045867]", "DNA-directed RNA polymerases I and III subunit AC40 [IPR033901]", "DNA2/NAM7-like helicase [IPR045055]", "DPM1-like [IPR039528]", "Daxx protein [IPR005012]", "Death-inducer obliterator 1 [IPR033082]", "Dedicator of cytokinesis [IPR026791]", "Defective-in-cullin neddylation protein [IPR014764]", "Dehydrogenase/reductase SDR member 4-like [IPR029511]", "Delta l-pyrroline-5-carboxylate synthetase [IPR005766]", "Delta(24)-sterol reductase [IPR040165]", "Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase Ech1-like [IPR045002]", "Delta-1-pyrroline-5-carboxylate dehydrogenase [IPR005931]", "Deoxycytidylate deaminase [IPR016473]", "Deoxycytidylate deaminase-related [IPR015517]", "Deoxyhypusine hydroxylase [IPR027517]", "Deoxyhypusine synthase [IPR002773]", "Deoxyuridine triphosphate nucleotidohydrolase [IPR008181]", "Dephospho-CoA kinase [IPR001977]", "Derlin [IPR007599]", "Dermcidin [IPR028130]", "Dermcidin/Lacritin [IPR043557]", "Desmoglein [IPR009123]", "Desmoplakin [IPR028462]", "Desmosomal cadherin [IPR009122]", "Destrin [IPR029924]", "Deubiquitinating enzyme MINDY-3/4 [IPR039785]", "Developmentally regulated GTP-binding protein [IPR045001]", "Diacylglycerol kinase [IPR037607]", "Dihydrofolate reductase [IPR012259]", "Dihydrolipoamide acetyltransferase/Pyruvate dehydrogenase protein X component [IPR045257]", "Dihydrolipoamide dehydrogenase [IPR006258]", "Dihydrolipoamide succinyltransferase [IPR006255]", "Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex [IPR006257]", "Dihydropyrimidinase-related protein 2 [IPR030615]", "Dihydropyrimidinase-related protein 5 [IPR030626]", "Dihydroxyacetone phosphate acyltransferase [IPR028353]", "Dimethylarginine dimethylaminohydrolase [IPR033199]", "Dipeptidyl-peptidase 3 [IPR005317]", "Diphthamide synthesis DHP2 [IPR010014]", "Diphthamide synthesis DPH1/DPH2 [IPR016435]", "Diphthine synthase [IPR004551]", "Disks large 1-like [IPR016313]", "Divalent ion tolerance protein, CutA [IPR004323]", "DnaJ homolog subfamily A member 1/2-like [IPR044713]", "DnaJ homolog subfamily C member 8 [IPR042858]", "DnaJ homologue subfamily C member 10 [IPR021170]", "DnaJ homologue subfamily C, GRV2/DNAJC13 [IPR044978]", "Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase [IPR039485]", "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48kDa subunit [IPR005013]", "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit Swp1 [IPR008814]", "Dolichyldiphosphatase 1 [IPR039666]", "Drebrin [IPR028438]", "Drebrin-like protein [IPR029923]", "Dual specificity protein phosphatase 12 [IPR016278]", "Dymeclin [IPR019142]", "Dynactin subunit 3 [IPR009991]", "Dynactin subunit 4 [IPR008603]", "Dynamin [IPR022812]", "Dynamin-1-like protein [IPR030556]", "Dynamin-2 [IPR027188]", "Dynamin-like 120kDa protein, mitochondrial [IPR033047]", "Dynamitin [IPR028133]", "Dynein 1 light intermediate chain [IPR008467]", "Dynein family light intermediate chain [IPR022780]", "Dynein light chain, type 1/2 [IPR001372]", "Dynein regulator LIS1 [IPR017252]", "Dyslexia-associated protein KIAA0319-like [IPR029865]", "Dystrophin/utrophin [IPR035436]", "E3 SUMO-protein ligase Nse2 (Mms21) [IPR026846]", "E3 UFM1-protein ligase 1 [IPR018611]", "E3 ubiquitin ligase Bre1 [IPR013956]", "E3 ubiquitin ligase RBR family [IPR031127]", "E3 ubiquitin ligase UBR4-like [IPR045189]", "E3 ubiquitin-protein ligase ARIH2 [IPR031126]", "E3 ubiquitin-protein ligase HECTD1/TRIP12-like [IPR045322]", "E3 ubiquitin-protein ligase RBBP6 family [IPR033489]", "E3 ubiquitin-protein ligase RNF123/RSPRY1-like [IPR045129]", "E3 ubiquitin-protein ligase RNF14 [IPR031128]", "E3 ubiquitin-protein ligase, SMURF1 type [IPR024928]", "EB1, Metazoa [IPR027739]", "EB2, vertebrate [IPR027735]", "ECSIT [IPR010418]", "EF-hand calcium-binding domain-containing protein 14 [IPR042352]", "EH domain-containing protein 1/3 [IPR029951]", "EH domain-containing protein 4 [IPR029952]", "ELL/occludin family [IPR031176]", "ELMO domain-containing protein 2 [IPR030724]", "ELP3/YhcC [IPR039661]", "ER lumen protein retaining receptor [IPR000133]", "ER membrane protein complex subunit 1 [IPR026895]", "ER membrane protein complex subunit 2-like [IPR039856]", "ER membrane protein complex subunit 7 [IPR039163]", "ERG2/sigma1 receptor-like [IPR006716]", "ERp19 [IPR037462]", "Ecd family [IPR010770]", "Electron transfer flavoprotein alpha subunit/FixB [IPR001308]", "Electron transfer flavoprotein, beta subunit [IPR012255]", "Electron transfer flavoprotein-ubiquinone oxidoreductase [IPR040156]", "Elongation factor 4 [IPR006297]", "Elongation factor G1-like [IPR045044]", "Elongator complex protein 1 [IPR006849]", "Elongator complex protein 2 [IPR037289]", "Elongator complex protein 3-like [IPR034687]", "Elongin B [IPR039049]", "Elongin-C [IPR039948]", "Emerin [IPR035004]", "Endonuclease III-like protein 1 [IPR030841]", "Endonuclease domain-containing 1 protein [IPR039015]", "Endophilin-A [IPR028501]", "Endophilin-B1 [IPR028503]", "Endoplasmic reticulum aninopeptidase 1 [IPR033520]", "Endoplasmic reticulum oxidoreductin 1 [IPR007266]", "Endoplasmic reticulum protein SC65 [IPR033213]", "Endoplasmic reticulum resident protein 29 [IPR016855]", "Endoplasmic reticulum vesicle transporter [IPR045888]", "Endothelin-converting enzyme 1 [IPR029734]", "Engulfment and cell motility protein 2 [IPR030713]", "Enhancer of mRNA-decapping protein 4-like [IPR045152]", "Enhancer of rudimentary [IPR000781]", "Enolase [IPR000941]", "Enolase-phosphatase E1 [IPR023943]", "Enolase-phosphatase E1, eukaryotes [IPR027511]", "Enoyl-CoA hydratase/isomerase [IPR001753]", "Enoyl-CoA hydratase/isomerase, HIBYL-CoA-H type [IPR032259]", "Ependymin [IPR001299]", "Ephrin receptor type-A /type-B [IPR016257]", "Epimerase family protein SDR39U1 [IPR010099]", "Epoxide hydrolase [IPR016292]", "Epoxide hydrolase-like [IPR000639]", "Ergosterol biosynthesis ERG4/ERG24 [IPR001171]", "Erlin1/2 [IPR033294]", "Est1/Ebs1-like [IPR045153]", "Esterase-like [IPR000801]", "Eukaryotic porin/Tom40 [IPR027246]", "Eukaryotic rRNA processing [IPR008610]", "Eukaryotic translation elongation factor 1 epsilon-1 [IPR042450]", "Eukaryotic translation initiation factor 2D [IPR039757]", "Eukaryotic translation initiation factor 3 subunit A [IPR027512]", "Eukaryotic translation initiation factor 3 subunit B [IPR011400]", "Eukaryotic translation initiation factor 3 subunit D [IPR007783]", "Eukaryotic translation initiation factor 3 subunit E [IPR016650]", "Eukaryotic translation initiation factor 3 subunit F [IPR027531]", "Eukaryotic translation initiation factor 3 subunit G [IPR017334]", "Eukaryotic translation initiation factor 3 subunit H [IPR027524]", "Eukaryotic translation initiation factor 3 subunit I [IPR027525]", "Eukaryotic translation initiation factor 3 subunit J [IPR013906]", "Eukaryotic translation initiation factor 3 subunit K [IPR009374]", "Eukaryotic translation initiation factor 3 subunit M [IPR027528]", "Eukaryotic translation initiation factor 3 subunit M eIF3m/COP9 signalosome complex subunit 7 COPS7 [IPR045237]", "Eukaryotic translation initiation factor 4 gamma 1 [IPR037584]", "Eukaryotic translation initiation factor 4 gamma 3 [IPR037585]", "Eukaryotic translation initiation factor 4B [IPR033107]", "Exocyst complex component EXOC2/Sec5 [IPR029175]", "Exocyst complex component EXOC3/Sec6 [IPR010326]", "Exocyst complex component EXOC5/Sec10 [IPR033960]", "Exocyst complex component EXOC6/Sec15 [IPR007225]", "Exocyst complex component Exo70 [IPR004140]", "Exocyst complex component Exo84 [IPR033961]", "Exocyst complex component Sec10-like [IPR009976]", "Exonuclease 1 [IPR032641]", "Exosome complex RNA-binding protein 1/RRP40/RRP4 [IPR026699]", "Exosome complex component RRP45 [IPR033100]", "Exosome complex exonuclease Rrp6-like [IPR045092]", "Exportin 4/7-like [IPR044189]", "Exportin-1/5 [IPR045065]", "Exportin-5 [IPR040018]", "Exportin-7 [IPR040021]", "Exportin-T [IPR040017]", "Ezrin/radixin/moesin [IPR011174]", "Ezrin/radixin/moesin-like [IPR000798]", "F-actin-capping protein subunit alpha [IPR002189]", "F-actin-capping protein subunit beta [IPR001698]", "FACT complex subunit Spt16 [IPR040258]", "FAD synthetase with the MoaB/Mog domain [IPR012183]", "FAD-dependent glycerol-3-phosphate dehydrogenase [IPR000447]", "FAD-dependent oxidoreductase SdhA/FrdA/AprA [IPR030664]", "FAM177 family [IPR028260]", "FAM3 family [IPR039220]", "FAM98 [IPR018797]", "FH1/FH2 domain-containing protein 1 [IPR027647]", "FUN14 [IPR007014]", "Fanconi anaemia protein FANCD2 [IPR029448]", "Fanconi anemia group I protein [IPR026171]", "Fascin [IPR010431]", "Fascin, metazoans [IPR024703]", "Fascin-1 [IPR030146]", "Fatty acid desaturase [IPR012171]", "Fatty acid oxidation complex, alpha subunit, mitochondrial [IPR012803]", "Fatty acid transport protein 4 [IPR030304]", "Fatty acyl-CoA reductase [IPR026055]", "Fcf2/DNTTIP2 [IPR039883]", "Ferredoxin-NADP+ reductase, adrenodoxin-type [IPR021163]", "Ferritin [IPR001519]", "Ferrochelatase [IPR001015]", "Fibrillarin [IPR000692]", "Filamin family [IPR044801]", "Filamin-B [IPR029874]", "Fimbrin/Plastin [IPR039959]", "Flagellum site-determining protein YlxH/ Fe-S cluster assembling factor NBP35 [IPR033756]", "Flap endonuclease 1 [IPR023426]", "Flotillin family [IPR027705]", "Formate-tetrahydrofolate ligase, FTHFS [IPR000559]", "Formin, protein diaphanous homologue 1 [IPR027653]", "Formin, protein diaphanous homologue 3 [IPR027654]", "Four and a half LIM domains protein 1 [IPR042997]", "Fragile X mental retardation syndrome-related protein [IPR040148]", "Fructosamine/Ketosamine-3-kinase [IPR016477]", "Fructose-bisphosphate aldolase, class-I [IPR000741]", "Fumarate hydratase, class II [IPR005677]", "Fumarate lyase family [IPR000362]", "Fumarylacetoacetase [IPR005959]", "G-protein alpha subunit, group 12/13 [IPR000469]", "G-protein alpha subunit, group I [IPR001408]", "G-protein, gamma subunit [IPR001770]", "G-rich sequence factor 1 [IPR033106]", "G10 protein [IPR001748]", "GDP dissociation inhibitor [IPR018203]", "GDP-fucose protein O-fucosyltransferase 1 [IPR039922]", "GDP-fucose protein O-fucosyltransferase [IPR019378]", "GH3 family [IPR004993]", "GINS complex subunit Sld5 [IPR008591]", "GINS complex, subunit Psf3 [IPR010492]", "GOLM1/CASC4 family [IPR026139]", "GPI mannosyltransferase [IPR005599]", "GPI transamidase component Gaa1 [IPR007246]", "GPI transamidase component PIG-T [IPR007245]", "GPI transamidase subunit PIG-U [IPR009600]", "GPI-anchor transamidase [IPR028361]", "GRASP55/65 [IPR007583]", "GRIM-19 [IPR009346]", "GRIP1-associated protein 1 [IPR026204]", "GTP-binding protein 1 [IPR039263]", "GTP-binding protein Era [IPR005662]", "GTP-binding protein Obg/CgtA [IPR014100]", "GTP-binding protein Rheb [IPR037586]", "Galactokinase [IPR000705]", "Galanin precursor [IPR008175]", "Gamma-adducin [IPR027772]", "Gamma-glutamylcyclotransferase [IPR017939]", "Gamma-tubulin complex component protein [IPR007259]", "Ganglioside GM2 activator [IPR028996]", "Ganglioside-induced differentiation-associated protein 1 [IPR034336]", "Gdt1 family [IPR001727]", "Gem-associated protein 4 [IPR033265]", "Glia maturation factor [IPR011171]", "Glomulin/ALF4 [IPR019516]", "Glucosamine-6-phosphate isomerase [IPR004547]", "Glucosamine-fructose-6-phosphate aminotransferase, isomerising [IPR005855]", "Glucose-6-phosphate dehydrogenase [IPR001282]", "Glucosidase II beta subunit-like [IPR039794]", "Glutamate 5-kinase/delta-1-pyrroline-5-carboxylate synthase [IPR005715]", "Glutamate carboxypeptidase 2-like [IPR039373]", "Glutamate-cysteine ligase catalytic subunit [IPR004308]", "Glutamate-tRNA ligase, bacterial/mitochondrial [IPR004527]", "Glutamate/acetylglutamate kinase [IPR001057]", "Glutamate/phenylalanine/leucine/valine dehydrogenase [IPR006095]", "Glutaminase [IPR015868]", "Glutamine-tRNA synthetase [IPR004514]", "Glutamyl-tRNA synthetase, archaeal/eukaryotic cytosolic [IPR004526]", "Glutamyl-tRNA(Gln) amidotransferase A subunit [IPR004412]", "Glutamyl/glutaminyl-tRNA synthetase [IPR000924]", "Glutathione S-transferase Omega/Tau-like [IPR045073]", "Glutathione S-transferase kappa [IPR044088]", "Glutathione S-transferase, Mu class [IPR003081]", "Glutathione S-transferase, omega-class [IPR005442]", "Glutathione Transferase family [IPR040079]", "Glutathione reductase, eukaryote/bacterial [IPR006322]", "Glutathione synthase [IPR005615]", "Glutathione-specific gamma-glutamylcyclotransferase [IPR006840]", "Glyceraldehyde-3-phosphate dehydrogenase, type I [IPR006424]", "Glyceraldehyde/Erythrose phosphate dehydrogenase family [IPR020831]", "Glycerol-3-phosphate O-acyltransferase/Dihydroxyacetone phosphate acyltransferase [IPR022284]", "Glycerol-3-phosphate acyltransferase, PlsB [IPR028354]", "Glycine cleavage system P protein [IPR020581]", "Glycine dehydrogenase (decarboxylating) [IPR003437]", "Glycogen debranching enzyme [IPR010401]", "Glycogen debranching enzyme, metazoa [IPR006421]", "Glycogen synthase [IPR008631]", "Glycogen/starch/alpha-glucan phosphorylase [IPR011833]", "Glycoside hydrolase family 30 [IPR001139]", "Glycoside hydrolase family 31 [IPR000322]", "Glycoside hydrolase family 47 [IPR001382]", "Glycoside hydrolase family 63 [IPR004888]", "Glycoside hydrolase, family 27 [IPR002241]", "Glycoside hydrolase, family 29 [IPR000933]", "Glycoside hydrolase, family 35 [IPR001944]", "Glycosyl transferase, family 25 [IPR002654]", "Glycosyl transferase, family 31 [IPR002659]", "Glycosyl transferase, family 35 [IPR000811]", "Glycosyl transferase, family 4 [IPR000715]", "Glycosyl transferase, family 8 [IPR002495]", "Glycyl-tRNA synthetase [IPR002315]", "Glycyl-tRNA synthetase/DNA polymerase subunit gamma-2 [IPR027031]", "Glyoxalase I [IPR004361]", "Glyoxalase domain-containing protein 4 [IPR043193]", "Golgi SNAP receptor complex, subunit 1 [IPR023601]", "Golgi apparatus protein 1 [IPR039728]", "Golgi integral membrane protein 4 [IPR042336]", "Golgi membrane protein 1 [IPR026143]", "Golgi phosphoprotein 3-like [IPR008628]", "Golgi to ER traffic protein 4 [IPR007317]", "Golgi-associated PDZ and coiled-coil motif-containing protein [IPR038879]", "Golgin subfamily A [IPR024858]", "Golgin subfamily A member 3 [IPR033288]", "Golgin subfamily A member 5 [IPR019177]", "Golgin subfamily B member 1 [IPR026202]", "Graves disease carrier protein [IPR002167]", "GroES chaperonin family [IPR020818]", "Growth arrest/ DNA-damage-inducible protein-interacting protein 1 [IPR018472]", "GrpE nucleotide exchange factor [IPR000740]", "Guanine nucleotide binding protein (G-protein), alpha subunit [IPR001019]", "Guanine nucleotide-exchange factor Sec12-like [IPR045260]", "H/ACA ribonucleoprotein complex non-core subunit Naf1 [IPR040309]", "H/ACA ribonucleoprotein complex, subunit Gar1/Naf1 [IPR007504]", "H/ACA ribonucleoprotein complex, subunit Nhp2, eukaryote [IPR002415]", "HAD hydrolase, LHPP/HDHD2 [IPR006355]", "HAD hydrolase, subfamily IA [IPR006439]", "HAD-superfamily hydrolase, subfamily IG, 5'-nucleotidase [IPR008380]", "HAD-superfamily hydrolase, subfamily IIA [IPR006357]", "HAD-superfamily hydrolase, subfamily IIA, CECR5 [IPR006353]", "HAUS augmin-like complex subunit 1 [IPR026243]", "HAUS augmin-like complex subunit 3 [IPR026206]", "HAUS augmin-like complex subunit 4 [IPR029327]", "HAUS augmin-like complex subunit 4, metazoa [IPR026214]", "HAUS augmin-like complex subunit 5 [IPR029131]", "HAUS complex subunit 5, metazoa [IPR026215]", "HCCA isomerase/glutathione S-transferase kappa [IPR014440]", "HIRA-interacting protein 3 [IPR037647]", "HMG-CoA lyase [IPR043594]", "Haem oxygenase [IPR002051]", "Haem oxygenase-like [IPR016053]", "Haloacid dehalogenase-like hydrolase [IPR041492]", "Ham1-like protein [IPR002637]", "Heat shock 70kDa protein 13 [IPR042048]", "Heat shock protein 70 family [IPR013126]", "Heat shock protein Hsp90 family [IPR001404]", "Heat shock protein Sti1-like [IPR045248]", "Helicase MOV-10 [IPR026122]", "Helicase XPB/Ssl2 [IPR001161]", "Helicase superfamily 1/2, DinG/Rad3-like [IPR045028]", "Heparan sulphate 2-O-sulfotransferase [IPR007734]", "Heterochromatin protein 1-binding protein 3 [IPR033061]", "Heterogeneous nuclear ribonucleoprotein C [IPR017347]", "Heterogeneous nuclear ribonucleoprotein K [IPR033090]", "Heterogeneous nuclear ribonucleoprotein M [IPR024667]", "Heterogeneous nuclear ribonucleoprotein U [IPR026745]", "Heterogeneous nuclear ribonucleoprotein U-like protein 1 [IPR027025]", "Hexokinase [IPR001312]", "High mobility group protein HMG-I/HMG-Y, chordates [IPR031079]", "High mobility group protein HMGA [IPR000116]", "High mobility group protein HMGB1 [IPR031076]", "High mobility group protein HMGB3 [IPR031077]", "High mobility group protein HMGN [IPR000079]", "Higher eukaryotic phosphomevalonate kinase [IPR005919]", "Histidine phosphatase superfamily, clade-1 [IPR013078]", "Histidine phosphatase superfamily, clade-2 [IPR000560]", "Histidine triad (HIT) protein [IPR001310]", "Histone H2A [IPR002119]", "Histone H4 [IPR001951]", "Histone acetyltransferase type B, catalytic subunit [IPR017380]", "Histone acetyltransferases subunit 3 [IPR019340]", "Histone deacetylase [IPR003084]", "Histone deacetylase complex, SAP18 subunit [IPR017250]", "Histone deacetylase family [IPR000286]", "Histone demethylase JHDM2-like [IPR045109]", "Histone lysine-specific demethylase [IPR017366]", "Histone-lysine N-methyltransferase 2A [IPR037927]", "Histone-lysine N-methyltransferase Smyd3 [IPR025805]", "HnRNP R/Q splicing factor [IPR006535]", "HnRNP-L/PTB [IPR006536]", "Holocytochrome c/c1 synthase [IPR000511]", "Host cell factor 1 [IPR037854]", "Host cell factor [IPR043536]", "Hydantoinase/dihydropyrimidinase [IPR011778]", "Hydroxymethylglutaryl-CoA reductase, class I/II [IPR002202]", "Hydroxymethylglutaryl-CoA reductase, eukaryotic/archaeal type [IPR004554]", "Hydroxymethylglutaryl-CoA reductase, metazoan [IPR004816]", "Hydroxymethylglutaryl-CoA synthase, eukaryotic [IPR010122]", "Hypoxanthine phosphoribosyl transferase [IPR005904]", "I-BAR domain containing protein IRSp53 [IPR030128]", "I-BAR domain containing protein IRSp53/IRTKS/Pinkbar [IPR027681]", "ICln [IPR003521]", "Immunity-related GTPase family Q protein [IPR040070]", "Importin beta family [IPR040122]", "Importin subunit alpha [IPR024931]", "Inhibitor of nuclear factor kappa-B kinase-interacting protein [IPR024152]", "Initiation factor 2B-related [IPR000649]", "Initiation factor 4G [IPR045208]", "Inner centromere protein [IPR039130]", "Inner nuclear membrane protein Man1 [IPR034997]", "Inorganic pyrophosphatase [IPR008162]", "Inosine triphosphate pyrophosphatase [IPR027502]", "Inosine-5'-monophosphate dehydrogenase [IPR005990]", "Inositol monophosphatase [IPR033942]", "Inositol monophosphatase, lithium-sensitive [IPR020552]", "Inositol monophosphatase-like [IPR000760]", "Insulin receptor substrate [IPR039011]", "Insulin-like growth factor 2 mRNA-binding protein 2 [IPR028743]", "Integral membrane protein 2 [IPR040145]", "Integral membrane protein EMC3/TMCO1-like [IPR002809]", "Integral membrane protein SYS1 [IPR016973]", "Integral membrane protein SYS1-related [IPR019185]", "Integrator complex subunit 14 [IPR039841]", "Integrator complex subunit 3 [IPR045334]", "Integrator complex subunit 7 [IPR033060]", "Integrin beta subunit [IPR015812]", "Integrin beta-1 subunit [IPR027071]", "Interferon-inducible double-stranded RNA-dependent protein kinase activator A [IPR033363]", "Interleukin enhancer-binding factor 3 [IPR033099]", "Intracellular chloride channel [IPR002946]", "Intracellular hyaluronic acid binding protein [IPR026203]", "Intracellular lipid binding protein [IPR031259]", "Intraflagellar transport protein 27 homologue, eukaryotes [IPR034112]", "Iron regulatory protein 1 [IPR029784]", "Iron-sulfur protein NUBPL-like [IPR044304]", "Isocitrate dehydrogenase NAD-dependent [IPR004434]", "Isocitrate dehydrogenase NADP-dependent [IPR004790]", "Isoleucine-tRNA ligase [IPR002301]", "Isoleucine-tRNA ligase, type 1 [IPR023585]", "Isoleucine-tRNA ligase, type 2 [IPR023586]", "Isopentenyl-diphosphate delta-isomerase, type 1 [IPR011876]", "Isoprenylcysteine carboxyl methyltransferase [IPR007269]", "Isovaleryl-CoA dehydrogenase [IPR034183]", "J-protein Zuotin/DnaJC2 [IPR044634]", "JNK-interacting protein 3/4 [IPR039911]", "Junction plakoglobin [IPR030461]", "Junctional adhesion molecule A [IPR042456]", "KH domain-containing BBP-like [IPR045071]", "KIF-1 binding protein [IPR022083]", "KIN17-like protein [IPR037321]", "KRR1 interacting protein 1 [IPR018034]", "Kae1/TsaD family [IPR017861]", "Keratin, type I [IPR002957]", "Kindlin/fermitin [IPR037843]", "Kinectin [IPR024854]", "Kinesin light chain [IPR002151]", "Kinesin-like protein KIF15/KIN-12E [IPR044986]", "Kinesin-like protein KIF20A [IPR027326]", "Kinesin-like protein KIF22 (Kid) [IPR026986]", "Kinesin-like protein [IPR027640]", "Kinetochore protein Spc25 [IPR045143]", "Kinetochore-Ndc80 subunit Spc24 [IPR013252]", "Ku70 [IPR006165]", "Ku80 [IPR024193]", "L-lactate dehydrogenase [IPR011304]", "L-lactate/malate dehydrogenase [IPR001557]", "LAMTOR1/MEH1 [IPR028209]", "LEM domain-containing protein 2 [IPR034994]", "LETM1/MDM38-like [IPR044202]", "LIM domain and actin-binding protein 1 [IPR028740]", "LIM domain and actin-binding protein LIMA-like [IPR045268]", "La domain containing protein [IPR045180]", "LanC-like protein, eukaryotic [IPR020464]", "Lanthionine synthetase C-like [IPR007822]", "Las1 [IPR007174]", "Lecithin:cholesterol/phospholipid:diacylglycerol acyltransferase [IPR003386]", "Leucine zipper transcription factor-like protein 1 [IPR026157]", "Leucine-rich PPR motif-containing protein [IPR033490]", "Leucine-tRNA ligase [IPR002302]", "Leucyl-tRNA synthetase, class Ia, archaeal/eukaryotic cytosolic [IPR004493]", "Leukocyte surface antigen CD47 [IPR006704]", "Leukotriene A4 hydrolase/leucine aminopeptidase [IPR012777]", "Leukotriene B4 12-hydroxydehydrogenase/15-oxo-prostaglandin 13-reductase [IPR014190]", "Like-Sm (LSM) domain containing protein, LSm4/SmD1/SmD3 [IPR027141]", "Linker histone H1/H5 [IPR005819]", "Lipase maturation factor [IPR009613]", "Lipase, eukaryotic [IPR025483]", "Lipid droplet-associated hydrolase [IPR019363]", "Lon protease [IPR027065]", "Lon protease homologue, chloroplastic/mitochondrial [IPR027503]", "Lon protease, bacterial/eukaryotic-type [IPR004815]", "Long-chain fatty acid CoA synthetase, eukaryotic [IPR045311]", "Low temperature viability protein Ltv1 [IPR007307]", "Luc7-related [IPR004882]", "Lunapark family [IPR040115]", "Lupus La protein [IPR002344]", "LysM and putative peptidoglycan-binding domain-containing protein 1-4 [IPR045030]", "Lysine-tRNA ligase, class II [IPR002313]", "Lysophosphatidylserine lipase ABHD12 [IPR026605]", "Lysosomal thioesterase PPT2 [IPR030295]", "Lysosome membrane protein II [IPR005429]", "Lysosome-associated membrane glycoprotein [IPR002000]", "MCT-1/Tma20 [IPR016437]", "MCU family [IPR039055]", "MDN2-binding protein [IPR039061]", "MICOS complex subunit MIC19/MIC25 [IPR007964]", "MICOS complex subunit MIC26/MIC27 [IPR019166]", "MICOS complex subunit MIC26/MIC27, animal [IPR033182]", "MICOS complex subunit Mic13 [IPR026769]", "MKRN-like [IPR045072]", "MOB kinase activator family [IPR005301]", "MRG [IPR008676]", "MRPS27/PTCD2 [IPR034913]", "MT-A70-like [IPR007757]", "Macrophage migration inhibitory factor [IPR001398]", "Mad2-like [IPR045091]", "Magnesium transporter protein 1 [IPR006844]", "Major facilitator superfamily [IPR011701]", "Major facilitator, sugar transporter-like [IPR005828]", "Mak16 protein [IPR006958]", "Malate dehydrogenase, NAD-dependent, cytosolic [IPR011274]", "Malate dehydrogenase, type 1 [IPR010097]", "Malate dehydrogenase, type 2 [IPR010945]", "Malectin [IPR039155]", "Malic oxidoreductase [IPR001891]", "Manganese/iron superoxide dismutase [IPR001189]", "Mannose-6-phosphate isomerase [IPR016305]", "Mannose-6-phosphate isomerase, type I [IPR001250]", "Mannose-6-phosphate receptor [IPR028927]", "Mannose-P-dolichol utilization defect 1 protein [IPR016817]", "Med25/PTOV1 [IPR045105]", "Mediator complex, subunit Med21 [IPR021384]", "Mediator complex, subunit Med23 [IPR021629]", "Mediator complex, subunit Med24, [IPR021429]", "Medium-chain dehydrogenase/reductase [IPR045010]", "Medium-chain specific acyl-CoA dehydrogenase [IPR034180]", "Melanoma-associated antigen D2 [IPR028810]", "Melanoma-associated antigen [IPR037445]", "Membralin [IPR019144]", "Membrane insertase YidC/ALB3/OXA1/COX18 [IPR001708]", "Membrane bound O-acyl transferase, MBOAT [IPR004299]", "Membrane-associated, eicosanoid/glutathione metabolism (MAPEG) protein [IPR001129]", "Mesoderm induction early response protein/metastasis-associated protein [IPR040138]", "Metal-dependent protein hydrolase [IPR003226]", "Metastasis-associated protein MTA2 [IPR037964]", "Methionine-tRNA ligase, type 1 [IPR023458]", "Methionyl-tRNA synthetase [IPR014758]", "Methyl-CpG binding protein MeCP2 [IPR017353]", "Methyl-CpG binding protein MeCP2/MBD4 [IPR045138]", "Methyl-CpG-binding domain protein 3 [IPR037965]", "Methylcrotonoyl-CoA carboxylase beta chain MCCB/AccD1-like [IPR045190]", "Methylmalonate-semialdehyde dehydrogenase [IPR010061]", "Methylpurine-DNA glycosylase [IPR003180]", "Methylthioadenosine phosphorylase (MTAP) [IPR010044]", "Methylthiotransferase [IPR005839]", "Methyltransferase, trithorax [IPR016569]", "Mevalonate kinase [IPR006205]", "Mevalonate/galactokinase [IPR006206]", "MiaB-like tRNA modifying enzyme, archaeal-type [IPR006466]", "Microtubule associated protein 1 [IPR026074]", "Microtubule-associated protein 1B [IPR027321]", "Microtubule-associated protein 1S [IPR027322]", "Microtubule-associated protein 4 [IPR027323]", "Microtubule-associated protein Jupiter [IPR033335]", "Microtubule-associated protein RP/EB [IPR027328]", "Microtubule-associated protein, MAP65/Ase1/PRC1 [IPR007145]", "Midasin [IPR012099]", "Mini-chromosome maintenance complex protein 4 [IPR008047]", "Mini-chromosome maintenance complex-binding protein [IPR019140]", "Mini-chromosome maintenance protein [IPR031327]", "Mitochondria fission 1 protein [IPR016543]", "Mitochondrial 18kDa protein [IPR019560]", "Mitochondrial 28S ribosomal protein S31 [IPR026299]", "Mitochondrial 28S ribosomal protein S34 [IPR032053]", "Mitochondrial ATP synthase subunit g, animal [IPR016702]", "Mitochondrial ATPase inhibitor [IPR007648]", "Mitochondrial F1-F0 ATP synthase subunit F, predicted [IPR019344]", "Mitochondrial Rho GTPase 1 [IPR029506]", "Mitochondrial Rho GTPase [IPR021181]", "Mitochondrial antiviral-signalling protein, metazoan [IPR026148]", "Mitochondrial calcium uniporter regulator 1 [IPR012439]", "Mitochondrial carrier UCP-like [IPR002030]", "Mitochondrial carrier protein Mtm1-like [IPR045315]", "Mitochondrial carrier protein [IPR002067]", "Mitochondrial glycoprotein [IPR003428]", "Mitochondrial import inner membrane translocase subunit Tim10 [IPR027100]", "Mitochondrial import inner membrane translocase subunit Tim44 [IPR017303]", "Mitochondrial import inner membrane translocase subunit Tim50 [IPR027111]", "Mitochondrial import inner membrane translocase subunit Tim8/13 [IPR039238]", "Mitochondrial import receptor subunit TOM5, metazoa [IPR029179]", "Mitochondrial import receptor subunit Tom22 [IPR005683]", "Mitochondrial inner membrane protein Mitofilin [IPR019133]", "Mitochondrial inner membrane translocase complex, subunit Tim17 [IPR005678]", "Mitochondrial inner membrane translocase complex, subunit Tim23 [IPR005681]", "Mitochondrial outer membrane translocase complex, subunit Tom5 [IPR019603]", "Mitochondrial phosphate carrier protein Pic2/Mir1-like [IPR044677]", "Mitochondrial processing peptidase subunit beta [IPR037718]", "Mitochondrial pyruvate carrier [IPR005336]", "Mitochondrial ribonuclease P catalytic subunit [IPR033495]", "Mitochondrial-processing peptidase subunit alpha [IPR037715]", "Mitofusin family [IPR027094]", "Mitofusin-1 [IPR027088]", "Mitofusin-2 [IPR027089]", "Mitogen-activated protein (MAP) kinase p38-like [IPR008352]", "Mitogen-activated protein (MAP) kinase phosphatase [IPR008343]", "Mitogen-activated protein (MAP) kinase, ERK1/2 [IPR008349]", "Mitogen-activated protein kinase 14 [IPR038784]", "Mitotic spindle checkpoint protein Bub1/Mad3 [IPR015661]", "Mo25-like [IPR013878]", "Molecular chaperone regulator BAG [IPR039773]", "Molybdate-anion transporter [IPR008509]", "Molybdate-anion transporter, animal type [IPR030163]", "Molybdopterin biosynthesis protein MoeA-like [IPR038987]", "Monocarboxylate transporter 1 [IPR030757]", "Monocarboxylate transporter [IPR004743]", "Monothiol glutaredoxin-related [IPR004480]", "Mortality factor 4-like protein 1 [IPR038011]", "Mpv17/PMP22 [IPR007248]", "Mrp/NBP35 ATP-binding protein [IPR019591]", "Multi drug resistance-associated protein [IPR005292]", "Multidrug resistance protein 1 [IPR030258]", "Multiple myeloma tumor-associated protein 2-like [IPR039207]", "Myelin expression factor 2 [IPR034632]", "Myeloid-derived growth factor [IPR018887]", "Myotubularin family [IPR030564]", "Myotubularin-related protein 14 [IPR039802]", "Myristoyl-CoA:protein N-myristoyltransferase [IPR000903]", "N(G),N(G)-dimethylarginine dimethylaminohydrolase 2 [IPR033202]", "N-acetylglucosamine-6-sulfatase [IPR012251]", "N-acetylglucosamine-6-sulfatase, metazoan [IPR015981]", "N-acetyltransferase B complex, non-catalytic subunit [IPR019183]", "N-alpha-acetyltransferase 40 [IPR039949]", "N-cadherin [IPR030051]", "N-end rule aminoacyl transferase [IPR030700]", "N-terminal acetyltransferase A, auxiliary subunit [IPR021183]", "N6-adenosine-methyltransferase MT-A70-like [IPR025848]", "N6-adenosine-methyltransferase non-catalytic subunit METTL14-like [IPR045123]", "NAD kinase 2, mitochondrial [IPR012355]", "NAD kinase [IPR002504]", "NAD(P) transhydrogenase, alpha subunit [IPR026255]", "NAD(P)H-quinone oxidoreductase subunit D/H [IPR022885]", "NAD/FAD transporter SLC25A32-like [IPR044712]", "NADH dehydrogenase 1, beta subcomplex, subunit 6 [IPR019174]", "NADH dehydrogenase, subunit C [IPR010218]", "NADH ubiquinone oxidoreductase, F subunit [IPR011537]", "NADH-quinone oxidoreductase subunit E-like [IPR002023]", "NADH-quinone oxidoreductase, chain I [IPR010226]", "NADH-ubiquinone oxidoreductase, 20 Kd subunit [IPR006138]", "NADH-ubiquinone oxidoreductase, subunit 10 [IPR019377]", "NADH-ubiquinone reductase complex 1 MLRQ subunit [IPR010530]", "NADH:cytochrome b5 reductase-like [IPR001834]", "NADH:ubiquinone oxidoreductase, NDUFB5/SGDH subunit [IPR019173]", "NADH:ubiquinone oxidoreductase, subunit 1/F420H2 oxidoreductase subunit H [IPR001694]", "NADH:ubiquinone oxidoreductase, subunit G [IPR010228]", "NADH:ubiquinone oxidoreductase, subunit NDUFB4 [IPR009866]", "NADPH-cytochrome P450 reductase [IPR023208]", "NDUFAF3/Mth938 domain-containing protein [IPR007523]", "NEDD8 ultimate buster 1 [IPR039749]", "NEDD8-activating enzyme E1 catalytic subunit [IPR030468]", "NEDD8-activating enzyme E1 regulatory subunit APP-BP1 [IPR030667]", "NOL6/Upt22 [IPR005554]", "NPC1-like [IPR004765]", "NSF attachment protein [IPR000744]", "Na(+)/H(+) exchange regulatory cofactor NHERF-1 [IPR031199]", "Na(+)/H(+) exchange regulatory cofactor NHERF-1/2 [IPR017300]", "Nck-associated protein 1 [IPR019137]", "Negative elongation factor E [IPR033102]", "Nesprin-2 [IPR030266]", "Nestin [IPR031211]", "Neurochondrin [IPR008709]", "Neurofilament light polypeptide [IPR027692]", "Neurofilament medium polypeptide [IPR027697]", "Neutral amino acid SLC6 transporter [IPR002438]", "Nicalin [IPR016574]", "Nicastrin [IPR008710]", "Nicotinamide phosphoribosyl transferase [IPR016471]", "Nitric oxide synthase-interacting protein [IPR016818]", "Nonaspanin (TM9SF) [IPR004240]", "Not2/Not3/Not5 [IPR040168]", "Nuclear MIS12/MIND complex subunit PMF1/Nnf1 [IPR007128]", "Nuclear RNA export factor [IPR030217]", "Nuclear cap-binding protein subunit 1 [IPR027159]", "Nuclear cap-binding protein subunit 3 [IPR019416]", "Nuclear factor hnRNPA1 [IPR021662]", "Nuclear fragile X mental retardation-interacting protein 2 [IPR032747]", "Nuclear mitotic apparatus protein 1 [IPR026650]", "Nuclear polyadenylated RNA-binding protein Nab2/ZC3H14 [IPR040366]", "Nuclear pore complex protein NUP98-NUP96 [IPR037637]", "Nuclear pore complex protein Nup133-like [IPR037624]", "Nuclear pore complex protein [IPR026054]", "Nuclear pore glycoprotein p62, metazoa [IPR033072]", "Nuclear pore membrane glycoprotein 210-like [IPR045197]", "Nuclear pore protein 84/107 [IPR007252]", "Nuclear protein localization protein 4 [IPR016563]", "Nuclear transport factor 2/Mtr2 [IPR045875]", "Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 [IPR026633]", "Nucleobindin [IPR040250]", "Nucleobindin-1 [IPR040253]", "Nucleobindin-2 [IPR028813]", "Nucleolar GTP-binding protein 1 [IPR024926]", "Nucleolar GTP-binding protein 2 [IPR024929]", "Nucleolar complex protein 2 [IPR005343]", "Nucleolar complex protein 4 [IPR027193]", "Nucleolar complex-associated protein 3 [IPR016903]", "Nucleolar pre-ribosomal-associated protein 1 [IPR039844]", "Nucleolar protein 10/Enp2 [IPR040382]", "Nucleolar protein 11 [IPR042859]", "Nucleolar protein 14 [IPR007276]", "Nucleolar protein 7 [IPR039626]", "Nucleolar protein 9 [IPR040000]", "Nucleolar protein Nop56/Nop58 [IPR045056]", "Nucleolar, Nop52 [IPR010301]", "Nucleoplasmin family [IPR004301]", "Nucleoporin NSP1/NUP62 [IPR026010]", "Nucleoporin NUP88/NUP82 [IPR037700]", "Nucleoporin Nup120/160 [IPR021717]", "Nucleoporin Nup186/Nup192/Nup205 [IPR021827]", "Nucleoporin Nup188 [IPR044840]", "Nucleoporin Nup37 [IPR037626]", "Nucleoporin Nup54/Nup57/Nup44 [IPR024864]", "Nucleoporin Nup85-like [IPR011502]", "Nucleoporin Nup88 [IPR019321]", "Nucleoporin Seh1 [IPR037597]", "Nucleoporin interacting component Nup93/Nic96 [IPR007231]", "Nucleoporin p58/p45 [IPR024882]", "Nucleoporin peptidase S59-like [IPR037665]", "Nucleoporin protein Ndc1-Nup [IPR019049]", "Nucleoporin, NUP53 [IPR017389]", "Nucleoporin, Nup155-like [IPR004870]", "Nucleoside 2-deoxyribosyltransferase [IPR007710]", "Nucleoside diphosphate kinase [IPR001564]", "Nucleoside-triphosphatase, THEP1 type [IPR004948]", "Nucleosome assembly protein (NAP) [IPR002164]", "NudC domain-containing protein 1 [IPR037895]", "NudC family [IPR037898]", "OBG-type GTPase [IPR045086]", "OCIA domain-containing protein 1/2 [IPR040187]", "OPI10 family [IPR031318]", "ORC ubiquitin ligase 1 [IPR039209]", "Occludin [IPR002958]", "Oligosaccharyl transferase complex, subunit OST3/OST6 [IPR021149]", "Oligosaccharyl transferase, STT3 subunit [IPR003674]", "Optic atrophy 3-like [IPR010754]", "Ornithine aminotransferase [IPR010164]", "Orotate phosphoribosyltransferase [IPR023031]", "Orotidine 5'-phosphate decarboxylase [IPR014732]", "Oxidized purine nucleoside triphosphate [IPR003563]", "Oxysterol-binding protein [IPR000648]", "P-type ATPase [IPR001757]", "P-type ATPase subfamily IIC, subunit alpha [IPR005775]", "P-type ATPase, subfamily IIA, SERCA-type [IPR005782]", "P-type ATPase, subfamily V [IPR006544]", "P-type ATPase, subfamily IB [IPR027256]", "P-type ATPase, subfamily IIB [IPR006408]", "PA2G4 family [IPR004545]", "PAT complex subunit CCDC47 [IPR012879]", "PCNA-associated factor [IPR040444]", "PDCD5-like [IPR002836]", "PDK/BCKDK protein kinase [IPR039028]", "PDZ and LIM domain protein 1 [IPR028537]", "PEST proteolytic signal-containing nuclear protein [IPR029169]", "PEX5/PEX5L [IPR024111]", "PH-interacting protein [IPR028738]", "PHF5-like [IPR005345]", "PITH domain-containing protein 1-like [IPR045099]", "PP2B [IPR043360]", "PSME3-interacting protein [IPR039845]", "Pachytene checkpoint protein 2-like [IPR044539]", "Palmitoyl protein thioesterase [IPR002472]", "Palmitoyl-protein thioesterase 1 [IPR030294]", "Palmitoyltransferase ZDHHC13 [IPR030290]", "Pantothenate kinase, acetyl-CoA regulated, two-domain type [IPR015844]", "Paraneoplastic encephalomyelitis antigen [IPR002343]", "Paraoxonase2 [IPR008364]", "Pat1-like [IPR039900]", "Paxillin [IPR001904]", "Pentatricopeptide repeat domain-containing protein 3 [IPR037387]", "Peptidase A22B, signal peptide peptidase [IPR007369]", "Peptidase C13, legumain [IPR001096]", "Peptidase C1B, bleomycin hydrolase [IPR004134]", "Peptidase C2, calpain family [IPR022684]", "Peptidase C26 [IPR011697]", "Peptidase C26, gamma-glutamyl hydrolase [IPR015527]", "Peptidase C50, separase [IPR005314]", "Peptidase C54 [IPR005078]", "Peptidase C65, otubain [IPR019400]", "Peptidase C69, dipeptidase A [IPR005322]", "Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase [IPR001930]", "Peptidase M1, aminopeptidase B [IPR015571]", "Peptidase M13 [IPR000718]", "Peptidase M14B, caboxypeptidase D [IPR015567]", "Peptidase M17, leucine aminopeptidase [IPR023042]", "Peptidase M17, leucine aminopeptidase/peptidase B [IPR011356]", "Peptidase M20 [IPR002933]", "Peptidase M24, methionine aminopeptidase [IPR001714]", "Peptidase M24A, methionine aminopeptidase, subfamily 2 [IPR002468]", "Peptidase M28 family [IPR045175]", "Peptidase M3A/M3B [IPR045090]", "Peptidase S10, serine carboxypeptidase [IPR001563]", "Peptidase S1C [IPR001940]", "Peptidase S26B [IPR001733]", "Peptidase S28 [IPR008758]", "Peptidase S8, subtilisin-related [IPR015500]", "Peptidase S9A, prolyl oligopeptidase [IPR002470]", "Peptidase T1A, proteasome beta-subunit [IPR000243]", "Peptidase family M49 [IPR039461]", "Peptidase, FtsH [IPR005936]", "Peptide chain release factor eRF1/aRF1 [IPR004403]", "Peptidyl-prolyl cis-trans isomerase FKBP2/11 [IPR044609]", "Peptidyl-prolyl cis-trans isomerase FKBP3 [IPR043368]", "Peptidyl-prolyl cis-trans isomerase FKBP4 [IPR031212]", "Peptidyl-prolyl cis-trans isomerase FKBP5 [IPR031210]", "Peptidyl-prolyl cis-trans isomerase PIN4 [IPR043323]", "Peptidyl-tRNA hydrolase, PTH2 [IPR002833]", "Pericentriolar material 1 protein [IPR024138]", "Perilipin [IPR004279]", "Periodic tryptophan protein 1 [IPR044285]", "Periodic tryptophan protein 2 [IPR027145]", "Peroxiredoxin, AhpC-type [IPR024706]", "Peroxiredoxin-5-like [IPR037944]", "Peroxiredoxin-like 2A [IPR032802]", "Peroxiredoxin-like 2A/B/C [IPR032801]", "Peroxisomal acyl-coenzyme A oxidase [IPR034171]", "Peroxisomal biogenesis factor 11 [IPR008733]", "Peroxisomal membrane protein 14 [IPR025655]", "Peroxisomal targeting signal 1 receptor PEX5, animals [IPR024113]", "Peroxisome membrane protein, Pex16 [IPR013919]", "Peroxysomal long chain fatty acyl transporter [IPR005283]", "Pescadillo [IPR010613]", "Pex19 protein [IPR006708]", "Phenylalanine-tRNA ligase, class IIc, beta subunit [IPR045060]", "Phenylalanyl-tRNA synthetase, class IIc, alpha subunit [IPR004529]", "Phenylalanyl-tRNA synthetase, class IIc, beta subunit, archael/eukaryotic type [IPR004531]", "Phenylalanyl-tRNA synthetase, class IIc, mitochondrial [IPR004530]", "Phosducin-like [IPR045037]", "Phosphatase Gpp1/Gpp2-like [IPR045228]", "Phosphatidate cytidylyltransferase [IPR000374]", "Phosphatidate cytidylyltransferase, eukaryota [IPR016720]", "Phosphatidyl serine synthase [IPR004277]", "Phosphatidylethanolamine-binding protein [IPR008914]", "Phosphatidylethanolamine-binding protein, eukaryotic [IPR035810]", "Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1 [IPR042165]", "Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1-like [IPR044596]", "Phosphatidylinositol kinase [IPR015433]", "Phosphatidylinositol transfer protein [IPR001666]", "Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma [IPR016279]", "Phosphatidylinositol-4-phosphate 5-kinase [IPR023610]", "Phosphatidylinositol-binding clathrin assembly protein [IPR030412]", "Phosphatidylinositol-glycan biosynthesis class S protein [IPR019540]", "Phosphatidylserine decarboxylase [IPR033177]", "Phosphatidylserine decarboxylase, eukaryotic type 1 [IPR033661]", "Phosphatidylserine decarboxylase-related [IPR003817]", "Phosphoacetylglucosamine mutase [IPR016657]", "Phosphodiesterase MJ0936/Vps29 [IPR000979]", "Phosphoenolpyruvate carboxykinase, GTP-utilising [IPR008209]", "Phosphoglucomutase [IPR045244]", "Phosphoglucose isomerase (PGI) [IPR001672]", "Phosphoglycerate kinase [IPR001576]", "Phosphoglycerate mutase 1 [IPR005952]", "Phosphoinositide phospholipase C family [IPR001192]", "Phospholipase B-like [IPR007000]", "Phosphoribosylformylglycinamidine cyclo-ligase [IPR004733]", "Phosphoribosylformylglycinamidine synthase PurL [IPR010073]", "Phosphoribosylglycinamide formyltransferase [IPR004607]", "Phosphoribosylglycinamide synthetase [IPR000115]", "Phosphorylase kinase alpha/beta subunit [IPR008734]", "Phosphorylated adapter RNA export protein [IPR039047]", "Phosphoserine aminotransferase [IPR022278]", "Phosphotyrosyl phosphatase activator, PTPA [IPR004327]", "Pinin [IPR039853]", "Pirin [IPR012093]", "Plakin [IPR043197]", "Plakophilin/Delta catenin [IPR028435]", "Plasma membrane calcium-transporting ATPase 1 [IPR030320]", "Plasminogen activator inhibitor 1 RNA-binding protein [IPR027205]", "Plastin-2/3 [IPR039956]", "Plectin [IPR030269]", "Podocalyxin [IPR017403]", "Polo kinase kinase [IPR022165]", "Poly(A) polymerase [IPR014492]", "Poly(ADP-ribose) glycohydrolase [IPR007724]", "Poly-U binding splicing factor, PUF60-like [IPR006532]", "Polyadenylate binding protein, human types 1, 2, 3, 4 [IPR006515]", "Polyadenylate-binding protein 2 [IPR034911]", "Polyadenylate-binding protein-interacting protein 2-like [IPR040396]", "Polynucleotide kinase 3 phosphatase [IPR013954]", "Polyprenyl synthetase [IPR000092]", "Polyribonucleotide 5-hydroxyl-kinase Clp1/Grc3 [IPR045116]", "Polyribonucleotide nucleotidyltransferase [IPR012162]", "Porin, eukaryotic type [IPR001925]", "Porphobilinogen deaminase [IPR000860]", "Pre-mRNA-processing factor 17 [IPR032847]", "Pre-mRNA-processing factor 19 [IPR038959]", "Pre-mRNA-processing factor 6/Prp1/STA1 [IPR027108]", "Pre-mRNA-processing factor Prp40 [IPR039726]", "Pre-mRNA-processing-splicing factor 8 [IPR027652]", "Pre-mRNA-splicing factor Cwf15/Cwc15 [IPR006973]", "Pre-mRNA-splicing factor 38 [IPR005037]", "Pre-mRNA-splicing factor Cwc2/Slt11 [IPR039171]", "Pre-mRNA-splicing factor SPF27 [IPR008409]", "Pre-mRNA-splicing factor Spp2-like [IPR045166]", "Pre-mRNA-splicing factor Syf1-like [IPR045075]", "Pre-rRNA-processing protein Esf1 [IPR039754]", "Pre-rRNA-processing protein PNO1-like [IPR039912]", "Prefoldin alpha subunit, archaea-type [IPR011599]", "Prefoldin alpha-like [IPR004127]", "Prefoldin beta-like [IPR002777]", "Prefoldin subunit 2 [IPR027235]", "Prefoldin subunit 3 [IPR016655]", "Prenylated rab acceptor PRA1 [IPR004895]", "Prenylcysteine oxidase [IPR017046]", "Prenyltransferase subunit beta [IPR045089]", "Presenilin/signal peptide peptidase [IPR006639]", "Primosome PriB/single-strand DNA-binding [IPR000424]", "Probable E3 ubiquitin-protein ligase makorin-2 [IPR026293]", "Probable ubiquitin carboxyl-terminal hydrolase FAF-X [IPR031226]", "Profilin [IPR005455]", "Profilin-1 [IPR029892]", "Profilin-2 [IPR029891]", "Profilin1/2/3, vertebrate [IPR005454]", "Progesterone-induced-blocking factor 1 [IPR026205]", "Prohibitin [IPR000163]", "Proliferating cell nuclear antigen, PCNA [IPR000730]", "Proline-rich protein PRCC [IPR018800]", "Proline-tRNA ligase, class IIa, archaeal-type [IPR004499]", "Prolyl 3-hydroxylase 1 [IPR039837]", "Prolyl 3-hydroxylase [IPR039575]", "Prolyl 4-hydroxylase [IPR045054]", "Prostaglandin E synthase 2 [IPR034334]", "Prostaglandin reductase 2 [IPR037399]", "Prostate apoptosis response 4 [IPR026117]", "Proteasomal ubiquitin receptor Rpn13/ADRM1 [IPR006773]", "Proteasome B-type subunit [IPR023333]", "Proteasome activator PA28 [IPR009077]", "Proteasome activator complex subunit 4 [IPR035309]", "Proteasome alpha-type subunit [IPR023332]", "Proteasome assembly chaperone 1 [IPR016565]", "Proteasome beta 3 subunit [IPR033811]", "Proteasome component Ecm29 [IPR024372]", "Proteasome subunit alpha 1 [IPR035144]", "Proteasome subunit alpha 3 [IPR037555]", "Proteasome subunit alpha 7 [IPR035190]", "Proteasome subunit alpha2 [IPR034644]", "Proteasome subunit alpha4 [IPR034647]", "Proteasome subunit alpha5 [IPR033812]", "Proteasome subunit alpha6 [IPR034642]", "Proteasome subunit beta 1 [IPR035202]", "Proteasome subunit beta 2 [IPR035206]", "Proteasome subunit beta 4 [IPR016295]", "Proteasome subunit beta 5 [IPR037558]", "Proteasome subunit beta 6 [IPR035140]", "Proteasome subunit beta 7 [IPR035216]", "Proteasome, subunit alpha/beta [IPR001353]", "Protein AATF/Bfr2 [IPR039223]", "Protein BANP [IPR042343]", "Protein BRAWNIN [IPR027858]", "Protein CIP2A [IPR042510]", "Protein Cms1 [IPR032704]", "Protein DEK [IPR044198]", "Protein FAM210A/B-like [IPR045866]", "Protein FAM3C [IPR039219]", "Protein Hgh1 [IPR039717]", "Protein ICln/Lot5/Saf5 [IPR039924]", "Protein LCHN/Anr2 [IPR018626]", "Protein LYRIC [IPR031402]", "Protein LZIC [IPR040065]", "Protein Lsm12-like [IPR039683]", "Protein Njmu-R1 [IPR028280]", "Protein PBDC1, metazoa/fungi [IPR008476]", "Protein PRRC1 [IPR026534]", "Protein PRRC2 [IPR033184]", "Protein Peter Pan-like [IPR045112]", "Protein RCC2 [IPR028641]", "Protein Red-like [IPR039896]", "Protein S100-A11 [IPR028482]", "Protein S100-A13 [IPR028487]", "Protein SON [IPR032922]", "Protein Sgt1-like [IPR044563]", "Protein TFG [IPR033512]", "Protein Yip1/4-like [IPR045231]", "Protein arginine N-methyltransferase PRMT5 [IPR007857]", "Protein arginine N-methyltransferase [IPR025799]", "Protein arginine methyltransferase NDUFAF7 [IPR003788]", "Protein canopy homolog [IPR042415]", "Protein diaphanous homologue 2 [IPR027644]", "Protein disulfide-isomerase A6-like [IPR044569]", "Protein disulphide isomerase [IPR005792]", "Protein disulphide-isomerase A4 [IPR017068]", "Protein farnesyltransferase subunit beta [IPR026872]", "Protein flightless-1 [IPR029919]", "Protein import receptor MAS20 [IPR002056]", "Protein import receptor MAS20, metazoan [IPR022422]", "Protein jagunal [IPR009787]", "Protein kinase C and casein kinase substrate in neurons protein 2 [IPR028521]", "Protein kinase C, alpha/beta/gamma types [IPR014375]", "Protein kinase Mps1 family [IPR027084]", "Protein kish [IPR009653]", "Protein of unknown function DUF1075 [IPR009432]", "Protein of unknown function DUF2046 [IPR019152]", "Protein of unknown function DUF719 [IPR007998]", "Protein patched/dispatched [IPR003392]", "Protein phosphatase 1 regulatory subunit 12A/B/C [IPR017401]", "Protein phosphatase 2A regulatory subunit PR55 [IPR000009]", "Protein phosphatase 2A, regulatory B subunit, B56 [IPR002554]", "Protein phosphatase 2C family [IPR015655]", "Protein phosphatase methylesterase, eukaryotic [IPR016812]", "Protein regulator of cytokinesis 1 [IPR032921]", "Protein spinster-like [IPR044770]", "Protein translocase SEC61 complex, gamma subunit [IPR008158]", "Protein translocase complex, SecE/Sec61-gamma subunit [IPR001901]", "Protein transport Sec61-beta/Sbh [IPR030671]", "Protein transport protein Got1 [IPR045176]", "Protein transport protein SEC31-like [IPR040251]", "Protein transport protein Sec23 [IPR037364]", "Protein transport protein SecG/Sec61-beta/Sbh [IPR016482]", "Protein unc-119 homologue A-like [IPR032977]", "Protein virilizer [IPR026736]", "Protein wntless [IPR009551]", "Protein-L-histidine N-pros-methyltransferase [IPR007884]", "Protein-L-isoaspartate(D-aspartate) O-methyltransferase [IPR000682]", "Protein-S-isoprenylcysteine O-methyltransferase [IPR025770]", "Protein-glutamate O-methyltransferase [IPR039763]", "Protein-tyrosine phosphatase, low molecular weight [IPR017867]", "Protein-tyrosine phosphatase, low molecular weight, mammalian [IPR002115]", "Protein-tyrosine phosphatase, non-receptor type-1/2 [IPR012265]", "Protein-tyrosine phosphatase, non-receptor type-6, -11 [IPR012152]", "Protein-tyrosine phosphatase-like, PTPLA [IPR007482]", "Protein/nucleic acid deglycase DJ-1 [IPR006287]", "Proteinase inhibitor I25A, stefin [IPR001713]", "Protoporphyrinogen oxidase [IPR004572]", "Pseudouridine synthase, TruD [IPR001656]", "Pterin 4 alpha carbinolamine dehydratase [IPR001533]", "Pumilio homologue 3 [IPR040059]", "Purine 5'-nucleotidase [IPR016695]", "Purine nucleoside phosphorylase I, inosine/guanosine-specific [IPR011270]", "Purine nucleoside phosphorylase [IPR011268]", "Purine-rich element binding protein family [IPR006628]", "Purine-rich element-binding protein alpha [IPR030500]", "Pyridine nucleotide-disulphide oxidoreductase, class I [IPR001100]", "Pyridoxal phosphate homeostasis protein [IPR011078]", "Pyridoxal phosphate-dependent decarboxylase [IPR002129]", "Pyridoxine kinase [IPR004625]", "Pyrimidine 5'-nucleotidase, eukaryotic [IPR006434]", "Pyrroline-5-carboxylate reductase [IPR000304]", "Pyruvate carboxylase [IPR005930]", "Pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit, subgroup y [IPR017597]", "Pyruvate dehydrogenase E1 component subunit beta [IPR027110]", "Pyruvate kinase [IPR001697]", "Queuine tRNA-ribosyltransferase accessory subunit QTRTD1 [IPR028592]", "Quinone oxidoreductase-like protein 1 [IPR042633]", "RAB11-binding protein RELCH [IPR040362]", "RAD3/XPD family [IPR001945]", "RFT1 [IPR007594]", "RINT-1/Tip20 [IPR007528]", "RLI1 [IPR013283]", "RNA (C5-cytosine) methyltransferase [IPR023267]", "RNA (C5-cytosine) methyltransferase, NOP2 [IPR023273]", "RNA 3'-terminal phosphate cyclase [IPR000228]", "RNA 3'-terminal phosphate cyclase type 2 [IPR016443]", "RNA binding protein HABP4/SERBP1 [IPR039764]", "RNA cytidine acetyltransferase NAT10 [IPR033688]", "RNA demethylase ALKBH5 [IPR032860]", "RNA exonuclease 4 [IPR034920]", "RNA methyltransferase Bin3-like [IPR039772]", "RNA polymerase I associated factor, A49-like [IPR009668]", "RNA polymerase II associated factor Paf1 [IPR007133]", "RNA polymerase II transcription factor SIII, subunit A [IPR010684]", "RNA polymerase II transcriptional coactivator Sub1/Tcp4-like [IPR045125]", "RNA polymerase II-associated protein RPAP1/Rba50 [IPR039913]", "RNA polymerase subunit Rpb4/RPC9 [IPR005574]", "RNA polymerase subunit Rpb7-like [IPR045113]", "RNA polymerase, subunit omega/Rpo6/RPB6 [IPR006110]", "RNA polymerase-associated protein Ctr9 [IPR031101]", "RNA transcription, translation and transport factor protein [IPR019265]", "RNA-binding motif protein 8 [IPR008111]", "RNA-binding protein 10 [IPR033095]", "RNA-binding protein 26 [IPR034861]", "RNA-binding protein 26/27 [IPR045137]", "RNA-binding protein 5 [IPR033094]", "RNA-binding protein 6 [IPR028806]", "RNA-binding protein EWS [IPR033109]", "RNA-binding protein FUS [IPR034459]", "RNA-binding protein NOB1 [IPR039907]", "RNA-induced silencing complex, nuclease component Tudor-SN [IPR016685]", "RNA-splicing ligase RtcB homologue, eukaryotic [IPR027513]", "RNA-splicing ligase, RtcB [IPR001233]", "RNase P subunit p30 [IPR002738]", "RPA-related protein RADX [IPR040893]", "RZZ complex, subunit Zw10 [IPR009361]", "Rab GDI protein [IPR000806]", "Rab GTPase-activating protein 1 [IPR033185]", "Rab-like protein 6 [IPR040385]", "Rab21 [IPR041833]", "Rab24 [IPR041828]", "Rab39 [IPR041818]", "Rab3GAP catalytic subunit [IPR045700]", "Rab3GAP regulatory subunit [IPR026059]", "Rab9 [IPR041824]", "Rabaptin [IPR003914]", "Rabaptin-5 [IPR029880]", "Rad21/Rec8-like protein [IPR039781]", "Ran GTPase [IPR002041]", "Ran binding protein RanBP1-like [IPR045255]", "Rap guanine nucleotide exchange factor 2 [IPR030739]", "Ras GTPase-activating protein-binding protein 1 [IPR034375]", "Ras GTPase-activating protein-binding protein 2 [IPR034377]", "Ras GTPase-activating protein-binding protein [IPR039539]", "Ras-like guanine nucleotide exchange factor [IPR008937]", "Ras-related protein Rab14 [IPR030702]", "Ras-related protein Ral [IPR028412]", "Ras-related protein Rap2 [IPR041840]", "Reduced folate carrier [IPR002666]", "Reduced folate transporter SLC19A1 [IPR028339]", "Regulator of MON1-CCZ1 complex [IPR040371]", "Regulatory associated protein of TOR [IPR004083]", "Remodelling complex subunit Rsc/polybromo [IPR037382]", "Renin receptor-like [IPR012493]", "Replication factor A protein 1 [IPR004591]", "Replication factor A protein 2 [IPR014646]", "Replication factor A protein-like [IPR040260]", "Replication factor C subunit 1 [IPR012178]", "Reticulon-4-interacting protein 1 [IPR037397]", "Reticulophagy receptor 1/3 [IPR043384]", "Reticulophagy regulator 3 [IPR033361]", "Retinal rod rhodopsin-sensitive cGMP 3', 5'-cyclic phosphodiesterase, delta subunit [IPR017287]", "Retinoblastoma-binding protein 5/Swd1 [IPR037850]", "Retinol-binding protein 1 [IPR031264]", "Retrieval of early ER protein Rer1 [IPR004932]", "Rho protein GDP-dissociation inhibitor [IPR000406]", "Rho-associated protein kinase 1/2 [IPR020684]", "Rho-related GTP-binding protein RhoG [IPR042734]", "Ribonuclease CAF1 [IPR006941]", "Ribonuclease H2, subunit A [IPR004649]", "Ribonuclease HII/HIII [IPR001352]", "Ribonuclease III [IPR011907]", "Ribonuclease Nob1, eukaryote [IPR017117]", "Ribonuclease T2, eukaryotic [IPR033697]", "Ribonuclease T2-like [IPR001568]", "Ribonucleases P/MRP protein subunit Pop1 [IPR039182]", "Ribonucleoprotein PTB-binding 1 [IPR034635]", "Ribonucleoside-diphosphate reductase large subunit [IPR039718]", "Ribonucleotide reductase small subunit [IPR033909]", "Ribonucleotide reductase small subunit family [IPR000358]", "Ribophorin I [IPR007676]", "Ribose-phosphate pyrophosphokinase [IPR005946]", "Ribosomal RNA adenine dimethylase [IPR011530]", "Ribosomal RNA adenine methyltransferase KsgA/Erm [IPR001737]", "Ribosomal RNA assembly KRR1 [IPR024166]", "Ribosomal RNA large subunit methyltransferase E [IPR015507]", "Ribosomal RNA processing protein 8 [IPR007823]", "Ribosomal RNA-processing protein 15 [IPR012459]", "Ribosomal RNA-processing protein Rrp9-like [IPR039241]", "Ribosomal biogenesis NSA2 family [IPR039411]", "Ribosomal biogenesis regulatory protein [IPR007023]", "Ribosomal biogenesis, methyltransferase, EMG1/NEP1 [IPR005304]", "Ribosomal protein L1 [IPR002143]", "Ribosomal protein L1, mitochondrial [IPR005879]", "Ribosomal protein L1/ribosomal biogenesis protein [IPR028364]", "Ribosomal protein L10P [IPR001790]", "Ribosomal protein L10e [IPR001197]", "Ribosomal protein L11, bacterial-type [IPR006519]", "Ribosomal protein L11/L12 [IPR000911]", "Ribosomal protein L12/P1/P2 family [IPR027534]", "Ribosomal protein L13 [IPR005822]", "Ribosomal protein L13, eukaryotic/archaeal [IPR005755]", "Ribosomal protein L13e [IPR001380]", "Ribosomal protein L14 [IPR039660]", "Ribosomal protein L14P [IPR000218]", "Ribosomal protein L15 [IPR030878]", "Ribosomal protein L15, bacterial-type [IPR005749]", "Ribosomal protein L15e [IPR000439]", "Ribosomal protein L17 [IPR000456]", "Ribosomal protein L18e [IPR000039]", "Ribosomal protein L19 [IPR001857]", "Ribosomal protein L2 [IPR002171]", "Ribosomal protein L2, archaeal-type [IPR023672]", "Ribosomal protein L21 [IPR001787]", "Ribosomal protein L21-like [IPR028909]", "Ribosomal protein L21e [IPR001147]", "Ribosomal protein L22, bacterial/chloroplast-type [IPR005727]", "Ribosomal protein L22/L17 [IPR001063]", "Ribosomal protein L22/L17, eukaryotic/archaeal [IPR005721]", "Ribosomal protein L22e [IPR002671]", "Ribosomal protein L23 [IPR019985]", "Ribosomal protein L24 [IPR003256]", "Ribosomal protein L24e [IPR023438]", "Ribosomal protein L24e-related [IPR000988]", "Ribosomal protein L25/L23 [IPR013025]", "Ribosomal protein L26/L24, eukaryotic/archaeal [IPR005756]", "Ribosomal protein L27e [IPR001141]", "Ribosomal protein L28/L24 [IPR026569]", "Ribosomal protein L28/L40, mitochondrial [IPR019192]", "Ribosomal protein L28e [IPR002672]", "Ribosomal protein L29/L35 [IPR001854]", "Ribosomal protein L29e [IPR002673]", "Ribosomal protein L3 [IPR000597]", "Ribosomal protein L3, archaeal/eukaryotic type [IPR045077]", "Ribosomal protein L3, bacterial/organelle-type [IPR019927]", "Ribosomal protein L30/YlxQ [IPR039109]", "Ribosomal protein L30e [IPR000231]", "Ribosomal protein L31e [IPR000054]", "Ribosomal protein L32e [IPR001515]", "Ribosomal protein L34Ae [IPR008195]", "Ribosomal protein L35A [IPR001780]", "Ribosomal protein L36e [IPR000509]", "Ribosomal protein L37/S30 [IPR010793]", "Ribosomal protein L37ae [IPR002674]", "Ribosomal protein L37e [IPR001569]", "Ribosomal protein L38e [IPR002675]", "Ribosomal protein L4, eukaryotic and archaeal type [IPR045240]", "Ribosomal protein L4/L1e [IPR002136]", "Ribosomal protein L44e [IPR000552]", "Ribosomal protein L5 [IPR002132]", "Ribosomal protein L5 eukaryotic/L18 archaeal [IPR005485]", "Ribosomal protein L50, mitochondria [IPR018305]", "Ribosomal protein L53, mitochondrial [IPR019716]", "Ribosomal protein L55, mitochondrial [IPR018615]", "Ribosomal protein L6 [IPR000702]", "Ribosomal protein L7, eukaryotic [IPR005998]", "Ribosomal protein L7/L12 [IPR000206]", "Ribosomal protein L7/L30 [IPR039699]", "Ribosomal protein L7A/L8 [IPR001921]", "Ribosomal protein L7Ae/L8/Nhp2 family [IPR018492]", "Ribosomal protein L9 [IPR000244]", "Ribosomal protein P2 [IPR044076]", "Ribosomal protein S10 [IPR001848]", "Ribosomal protein S10, eukaryotic/archaeal [IPR005729]", "Ribosomal protein S11 [IPR001971]", "Ribosomal protein S12/S23 [IPR006032]", "Ribosomal protein S12e [IPR000530]", "Ribosomal protein S13 [IPR001892]", "Ribosomal protein S14 [IPR001209]", "Ribosomal protein S15 [IPR000589]", "Ribosomal protein S15, bacterial-type [IPR005290]", "Ribosomal protein S15P [IPR023029]", "Ribosomal protein S16 [IPR000307]", "Ribosomal protein S17, archaeal/eukaryotic [IPR028333]", "Ribosomal protein S17/S11 [IPR000266]", "Ribosomal protein S17e [IPR001210]", "Ribosomal protein S18 [IPR001648]", "Ribosomal protein S19e [IPR001266]", "Ribosomal protein S2 [IPR001865]", "Ribosomal protein S2, eukaryotic [IPR027498]", "Ribosomal protein S2, eukaryotic/archaeal [IPR005707]", "Ribosomal protein S21e [IPR001931]", "Ribosomal protein S22, mitochondrial [IPR019374]", "Ribosomal protein S23, eukaryotic/archaeal [IPR005680]", "Ribosomal protein S23, mitochondrial [IPR019520]", "Ribosomal protein S23/S29, mitochondrial [IPR019368]", "Ribosomal protein S24/S35, mitochondrial [IPR039848]", "Ribosomal protein S24e [IPR001976]", "Ribosomal protein S25 [IPR004977]", "Ribosomal protein S28e [IPR000289]", "Ribosomal protein S29, mitochondrial [IPR008092]", "Ribosomal protein S3, eukaryotic/archaeal [IPR005703]", "Ribosomal protein S30 [IPR006846]", "Ribosomal protein S30, mitochondrial [IPR039982]", "Ribosomal protein S3Ae [IPR001593]", "Ribosomal protein S4/S9 [IPR022801]", "Ribosomal protein S4/S9, eukaryotic/archaeal [IPR005710]", "Ribosomal protein S4e [IPR000876]", "Ribosomal protein S5 [IPR000851]", "Ribosomal protein S5, eukaryotic/archaeal [IPR005711]", "Ribosomal protein S5/S7 [IPR000235]", "Ribosomal protein S5/S7, eukaryotic/archaeal [IPR005716]", "Ribosomal protein S6 kinase II [IPR016239]", "Ribosomal protein S6, eukaryotic [IPR014401]", "Ribosomal protein S6e [IPR001377]", "Ribosomal protein S7e [IPR000554]", "Ribosomal protein S8 [IPR000630]", "Ribosomal protein S8e [IPR001047]", "Ribosomal protein S8e/ribosomal biogenesis NSA2 [IPR022309]", "Ribosomal protein S9 [IPR000754]", "Ribosome assembly factor Mrt4 [IPR033867]", "Ribosome biogenesis factor, NIP7 [IPR016686]", "Ribosome biogenesis protein BRX1 [IPR026532]", "Ribosome biogenesis protein Bms1/Tsr1 [IPR039761]", "Ribosome biogenesis protein Nop16 [IPR019002]", "Ribosome biogenesis protein Nop53/GLTSCR2 [IPR011687]", "Ribosome biogenesis protein Rpf2 [IPR039770]", "Ribosome maturation protein Sdo1/SBDS [IPR002140]", "Ribosome maturation protein Sdo1/SBDS-like [IPR039100]", "Ribosome recycling factor [IPR002661]", "Ribosome-binding ATPase YchF/Obg-like ATPase 1 [IPR004396]", "Ribosome-binding protein 1 [IPR040248]", "RidA family [IPR006056]", "Root UVB sensitive family [IPR006968]", "RuvB-like [IPR027238]", "RuvB-like helicase 1 [IPR037938]", "RuvB-like helicase 2 [IPR037942]", "S-adenosylmethionine synthetase [IPR002133]", "S-formylglutathione hydrolase [IPR014186]", "S-phase kinase-associated protein 1 [IPR016897]", "S-phase kinase-associated protein 1-like [IPR001232]", "SAFB-like transcription modulator [IPR034780]", "SAPAP family [IPR005026]", "SCAMP [IPR007273]", "SERRATE/Ars2 [IPR039727]", "SIT4 phosphatase-associated protein family [IPR007587]", "SKI-interacting protein, SKIP [IPR017862]", "SLC12A transporter family [IPR004842]", "SNF5/SMARCB1/INI1 [IPR006939]", "SNU66/SART1 family [IPR005011]", "SNX17/27/31 [IPR037831]", "SOS response associated peptidase (SRAP) [IPR003738]", "SOUL haem-binding protein [IPR006917]", "SSNA1 family [IPR033362]", "STEEP-like [IPR029704]", "SUMO-activating enzyme subunit Uba2 [IPR030661]", "SUN domain-containing protein 1 [IPR018539]", "SUN domain-containing protein 1-5 [IPR045119]", "SUN domain-containing protein 2 [IPR030272]", "SURP and G-patch domain-containing protein 1/2 [IPR040169]", "SWI/SNF complex subunit BAF57 [IPR030089]", "SWI/SNF complex subunit BRG1 [IPR030100]", "SWI/SNF complex subunit SMARCC1 [IPR030087]", "SWI/SNF complex subunit SMARCC2 [IPR038044]", "SWI/SNF-like complex subunit BAF250a [IPR030094]", "SWI/SNF-like complex subunit BAF250/Osa [IPR021906]", "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 [IPR038041]", "Saposin [IPR008373]", "Saposin, chordata [IPR021165]", "Sas10/Utp3/C1D [IPR007146]", "Scaffold attachment factor B1 [IPR034781]", "Scaffold attachment factor B2 [IPR034782]", "Scavenger mRNA decapping enzyme DcpS/DCS2 [IPR008594]", "Schlafen family [IPR029684]", "Sda1 [IPR027312]", "Sec1-like protein [IPR001619]", "Sec13/Seh1 family [IPR037363]", "Sec20 [IPR005606]", "SecY/SEC61-alpha family [IPR002208]", "Selenophosphate synthetase [IPR004536]", "Sentrin-specific protease 3 [IPR037945]", "Sepiapterin reductase [IPR006393]", "Septin 2 [IPR008113]", "Septin 6 [IPR030644]", "Septin 7 [IPR008115]", "Septin 9 [IPR030645]", "Septin [IPR016491]", "Septin and tuftelin interacting protein [IPR024933]", "Serine hydroxymethyltransferase [IPR001085]", "Serine-tRNA ligase, type1 [IPR002317]", "Serine/arginine-rich splicing factor 10 [IPR034476]", "Serine/arginine-rich splicing factor 11 [IPR034447]", "Serine/arginine-rich splicing factor 6 [IPR029541]", "Serine/threonine protein phosphatase 5 [IPR011236]", "Serine/threonine-protein kinase Atg1-like [IPR045269]", "Serine/threonine-protein kinase OSR1 [IPR028749]", "Serine/threonine-protein kinase PAK2 [IPR035065]", "Serine/threonine-protein kinase TOR [IPR026683]", "Serine/threonine-protein kinase Vps15-like [IPR045162]", "Serine/threonine-protein phosphatase 2A subunit A, metazoa [IPR031090]", "Serine/threonine-protein phosphatase 4 regulatory subunit 1 [IPR031087]", "Serine/threonine-protein phosphatase PP1-alpha catalytic subunit [IPR037979]", "Serpin H1 [IPR033547]", "Serpin family [IPR000215]", "Short transmembrane mitochondrial protein 1 [IPR027854]", "Short-chain dehydrogenase/reductase SDR [IPR002347]", "Sideroflexin-4 [IPR028825]", "Sigma intracellular receptor 2 [IPR016964]", "Signal peptidase complex catalytic subunit SEC11A [IPR037712]", "Signal peptidase complex subunit Spc2/SPCS2 [IPR009582]", "Signal recognition particle SRP9 [IPR039914]", "Signal recognition particle receptor, beta subunit [IPR019009]", "Signal recognition particle subunit SRP68 [IPR026258]", "Signal recognition particle, SRP14 subunit [IPR003210]", "Signal recognition particle, SRP54 subunit [IPR022941]", "Signal recognition particle, SRP54 subunit, eukaryotic [IPR006325]", "Signal recognition particle, SRP72 subunit [IPR026270]", "Signal recognition particle, SRP9 subunit [IPR008832]", "Sin3 associated polypeptide p18 [IPR010516]", "Single-stranded DNA-binding protein [IPR011344]", "Sirtuin family [IPR003000]", "Sister chromatid cohesion protein Pds5 [IPR039776]", "Ski3/TTC37 [IPR039226]", "Sm-like protein Lsm6/SmF [IPR016487]", "Sm-like protein Lsm7 [IPR017132]", "Sm-like protein Lsm7/SmG [IPR044641]", "Smac/DIABLO protein [IPR015142]", "Small (40S) ribosomal subunit Asc1/RACK1 [IPR045223]", "Small GTPase Rho [IPR003578]", "Small GTPase [IPR001806]", "Small GTPase superfamily, ARF type [IPR024156]", "Small GTPase superfamily, ARF/SAR type [IPR006689]", "Small GTPase superfamily, SAR1-type [IPR006687]", "Small GTPase, Ras-type [IPR020849]", "Small acidic protein [IPR026714]", "Small nuclear ribonucleoprotein E [IPR027078]", "Small nuclear ribonucleoprotein Sm D2 [IPR027248]", "Small nuclear ribonucleoprotein Sm D3 [IPR034099]", "Small-subunit processome, Utp11 [IPR007144]", "Small-subunit processome, Utp14 [IPR006709]", "Smooth muscle protein/calponin [IPR003096]", "Snf7 family [IPR005024]", "Sodium/potassium-transporting ATPase subunit beta [IPR000402]", "Sodium/potassium-transporting ATPase subunit beta, chordates [IPR015565]", "Sodium:dicarboxylate symporter [IPR001991]", "Sodium:neurotransmitter symporter [IPR000175]", "Solute carrier family 12 member 9 [IPR030345]", "Solute carrier family 35 member SLC35F1/F2/F6 [IPR009262]", "Sorbitol dehydrogenase-like [IPR045306]", "Sorting nexin 9 family [IPR014536]", "Sorting nexin-1 [IPR028660]", "Sorting nexin-17 [IPR028666]", "Sorting nexin-19 [IPR034908]", "Sorting nexin-2 [IPR028653]", "Sorting nexin-27 [IPR028667]", "Sorting nexin-4 [IPR034783]", "Sorting nexin-5 [IPR028654]", "Sorting nexin-5/6/32 [IPR014637]", "Sorting nexin-6 [IPR028657]", "Sorting nexin-9 [IPR028644]", "Spartin-like [IPR045036]", "Spectrin, beta subunit [IPR016343]", "Spermatid perinuclear RNA-binding protein [IPR030446]", "Spermidine/spermine synthase, eukaryotes [IPR030668]", "Spermidine/spermine synthases [IPR001045]", "Spermine synthase, animal [IPR015576]", "Sphingolipid delta(4)-desaturase DES1 [IPR031196]", "Sphingolipid delta4-desaturase [IPR011388]", "Sphingomyelin phosphodiesterase 4 [IPR024129]", "Sphingosine N-acyltransferase Lag1/Lac1-like [IPR016439]", "Splicing factor 3A subunit 1 [IPR045146]", "Splicing factor 3A subunit 3 [IPR031776]", "Splicing factor 3B subunit 1-like [IPR038737]", "Splicing factor 45 [IPR040052]", "Splicing factor ELAV/Hu [IPR006548]", "Splicing factor, RBM39-like [IPR006509]", "Splicing factor, arginine/serine-rich 19 [IPR042841]", "Squalene cyclase [IPR018333]", "Squalene monooxygenase [IPR040125]", "Squalene synthase-like [IPR006449]", "Squalene/phytoene synthase [IPR002060]", "Stathmin family [IPR000956]", "Sterile alpha and TIR motif-containing protein 1 [IPR039184]", "Steroidogenic acute regulatory protein-like [IPR000799]", "Sterol O-acyltransferase, ACAT/DAG/ARE types [IPR014371]", "Sterol O-acyltransferase, metazoa [IPR030687]", "Sterol transport protein NPC2-like [IPR039670]", "Stomatin [IPR028515]", "Stomatin/HflK/HflC family [IPR001972]", "Stromal interaction molecule 1 [IPR030463]", "Stromal interaction molecule [IPR037608]", "Structural maintenance of chromosomes protein 1A, metazoan [IPR029683]", "Structural maintenance of chromosomes protein [IPR024704]", "Structure-specific recognition protein [IPR000969]", "Succinate dehydrogenase, flavoprotein subunit [IPR011281]", "Succinate dehydrogenase/fumarate reductase iron-sulphur protein [IPR004489]", "Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [IPR014006]", "Succinate semialdehyde dehydrogenase [IPR010102]", "Succinate--CoA synthetase, beta subunit [IPR005809]", "Succinyl-CoA ligase, alpha subunit [IPR005810]", "Sulfhydryl oxidase [IPR039798]", "Sulfotransferase [IPR005331]", "Sulfurtransferase TST/MPST-like [IPR045078]", "Surface antigen D15-like [IPR039910]", "Surfeit locus 1/4 [IPR045214]", "Surfeit locus 4 [IPR002995]", "Surfeit locus 6 [IPR007019]", "Symplekin/Pta1 [IPR021850]", "Synaptic vesicle protein SV2 [IPR022308]", "Synaptobrevin [IPR001388]", "Synaptogyrin [IPR016579]", "Syntaxin [IPR045242]", "Syntaxin-3 [IPR031186]", "Syntenin-1 [IPR030528]", "Synthesis of cytochrome c oxidase, Sco1/Sco2 [IPR017276]", "T-complex protein 1, alpha subunit [IPR012715]", "T-complex protein 1, beta subunit [IPR012716]", "T-complex protein 1, delta subunit [IPR012717]", "T-complex protein 1, epsilon subunit [IPR012718]", "T-complex protein 1, eta subunit [IPR012720]", "T-complex protein 1, gamma subunit [IPR012719]", "T-complex protein 1, theta subunit [IPR012721]", "T-complex protein 1, zeta subunit [IPR012722]", "TACC family [IPR039915]", "TAF15/EWS/TLS family [IPR034870]", "TATA binding associated factor 15 [IPR034875]", "TATA element modulatory factor 1 DNA binding [IPR022092]", "TATA-binding protein-associated factor Mot1 [IPR044972]", "TB2/DP1/HVA22-related protein [IPR004345]", "TE2IP/Rap1 [IPR039595]", "TFP11/STIP/Ntr1 [IPR045211]", "TH1 protein [IPR006942]", "THO complex subunit 2 [IPR040007]", "THO complex subunit 6 [IPR042626]", "THO complex, subunit 5 [IPR019163]", "THO complex, subunit THOC1 [IPR021861]", "THRAP3/BCLAF1 family [IPR029199]", "THUMP domain-containing protein 1-like [IPR040183]", "TIP41-like protein [IPR007303]", "TMEM14 family [IPR005349]", "TMEM192 family [IPR029399]", "TMEM33/Pom33 family [IPR005344]", "TMEM85/ER membrane protein complex subunit 4 [IPR009445]", "TNF receptor-associated factor 2 [IPR027133]", "TNF receptor-associated factor TRAF [IPR043211]", "TNF receptor-associated factor TRAF, metazoa [IPR012227]", "TOX high mobility group box family member 4 [IPR037985]", "TPP-binding domain containing protein HACL1-like [IPR045025]", "TPX2 [IPR009675]", "TRAPP I complex, subunit 5 [IPR016696]", "TREX component Tex1/THOC3 [IPR040132]", "TRIC channel [IPR007866]", "Tankyrase 1-binding protein-like [IPR040006]", "TatSF1-like [IPR034393]", "Taxilin family [IPR026183]", "Telomerase RNA component interacting RNase [IPR038838]", "Telomere-associated protein Rif1 [IPR028566]", "Testin [IPR027683]", "Testis-expressed protein 10/pre-rRNA-processing protein Ipi1 [IPR037947]", "Tetrahydrofolate dehydrogenase/cyclohydrolase [IPR000672]", "Tetraspanin, animals [IPR000301]", "Tetraspanin/Peripherin [IPR018499]", "Tetratricopeptide repeat protein 19 [IPR040395]", "Tetratricopeptide repeat protein 26 [IPR030511]", "Tetratricopeptide repeat protein 38 [IPR033891]", "The Golgi pH regulator/GPCR-type G protein [IPR015672]", "The WD repeat Cdc20/Fizzy family [IPR033010]", "ThiF/MoeB/HesA family [IPR045886]", "Thiamine pyrophosphate enzyme [IPR045229]", "Thiolase [IPR002155]", "Thioredoxin domain-containing protein 17-like [IPR045108]", "Thioredoxin-related transmembrane protein 2 [IPR039101]", "Thioredoxin/glutathione reductase selenoprotein [IPR006338]", "Threonine-tRNA ligase, class IIa [IPR002320]", "Thymidine kinase [IPR001267]", "Thymidylate kinase [IPR018094]", "Thymidylate synthase [IPR000398]", "Thymidylate synthase/dCMP hydroxymethylase [IPR045097]", "Thyroid hormone receptor-associated protein 3 [IPR026667]", "Tight junction protein ZO [IPR005417]", "Tight junction protein ZO-1 [IPR005418]", "Tim23-like [IPR045238]", "Tim44-like [IPR039544]", "Timeless [IPR044998]", "Tissue alpha-L-fucosidase [IPR028755]", "TmcA/NAT10/Kre33 [IPR032672]", "Tom40 [IPR037930]", "Torsin 1/2 [IPR017378]", "Torsin [IPR010448]", "Torsin-1A-interacting protein 1/2 [IPR008662]", "Torsin-1B [IPR030550]", "Torsin-3A [IPR030552]", "TraB/PrgY/GumN family [IPR002816]", "Trans-isoprenyl diphosphate synthases, eukaryotic-type [IPR044844]", "Transaldolase type 1 [IPR004730]", "Transaldolase/Fructose-6-phosphate aldolase [IPR001585]", "Transcription elongation factor SPT5 [IPR039659]", "Transcription elongation factor Spt5, eukaryote [IPR017071]", "Transcription elongation factor Spt6 [IPR017072]", "Transcription elongation factor, IIS-type [IPR035100]", "Transcription elongation factor, TFIIS [IPR006289]", "Transcription elongation regulator 1-like [IPR045148]", "Transcription facto Tfc3-like [IPR044210]", "Transcription factor BTF3 [IPR039370]", "Transcription factor E [IPR039997]", "Transcription factor II-I [IPR016659]", "Transcription factor STAT [IPR001217]", "Transcription factor TFIIB [IPR000812]", "Transcription factor Tfc4/TFIIIC-102/Sfc4 [IPR039340]", "Transcription initiation factor IIF, alpha subunit [IPR008851]", "Transcription initiation factor TFIID subunit 6 [IPR037796]", "Transcription intermediary factor 1-beta [IPR037373]", "Transcription-associated protein 1 [IPR033317]", "Transcriptional regulatory protein Sin3-like [IPR039774]", "Transcriptional regulatory protein Sin3a [IPR037969]", "Transcriptional repressor p66 [IPR040386]", "Transducin beta-like protein 2 [IPR042410]", "Transferrin receptor protein 1 [IPR029513]", "Transforming growth factor-beta-related [IPR015615]", "Transgelin-2 [IPR001061]", "Translation Initiation factor eIF- 4e [IPR001040]", "Translation elongation factor EF1A, eukaryotic/archaeal [IPR004539]", "Translation elongation factor EFG/EF2 [IPR004540]", "Translation elongation factor EFTs/EF1B [IPR001816]", "Translation elongation factor EFTu/EF1A, bacterial/organelle [IPR004541]", "Translation elongation factor IF5A-like [IPR001884]", "Translation initiation factor 2, alpha subunit [IPR011488]", "Translation initiation factor 2A [IPR011387]", "Translation initiation factor 3 complex subunit L [IPR019382]", "Translation initiation factor IF- 2 [IPR015760]", "Translation initiation factor IF2/IF5 [IPR045196]", "Translation initiation factor IF6 [IPR002769]", "Translation machinery-associated protein 16 [IPR021346]", "Translation release factor pelota [IPR004405]", "Translational activator Gcn1 [IPR033173]", "Translationally controlled tumour protein [IPR018105]", "Translin [IPR033956]", "Translin family [IPR002848]", "Translocation associated membrane protein [IPR016447]", "Translocation protein Sec62 [IPR004728]", "Translocation protein Sec63 [IPR027137]", "Translocator protein [IPR030164]", "Translocon-associated [IPR008855]", "Translocon-associated protein (TRAP), alpha subunit [IPR005595]", "Transmembrane emp24 domain-containing protein 5 [IPR015717]", "Transmembrane emp24 domain-containing protein 7 [IPR015718]", "Transmembrane emp24 domain-containing protein [IPR015720]", "Transmembrane protein 109 [IPR039492]", "Transmembrane protein 126 [IPR009801]", "Transmembrane protein 160 [IPR026801]", "Transmembrane protein 201 [IPR040041]", "Transmembrane protein 205 [IPR042623]", "Transmembrane protein 214 [IPR019308]", "Transmembrane protein 230 [IPR044234]", "Transmembrane protein 230/134 [IPR008590]", "Transmembrane protein 43 family [IPR012430]", "Transmembrane protein 65 [IPR019537]", "Transmembrane protein GPR107/GPR108-like [IPR009637]", "Transport protein particle (TRAPP) component [IPR007194]", "Transposase, L1 [IPR004244]", "Treacle protein [IPR017859]", "Tricarboxylate/iron carrier [IPR004686]", "Triosephosphate isomerase [IPR000652]", "Triosephosphate isomerase, bacterial/eukaryotic [IPR022896]", "Tropomodulin [IPR004934]", "Tropomodulin-1 [IPR030135]", "Tropomodulin-3 [IPR030133]", "Tropomyosin [IPR000533]", "Tryptophan-tRNA ligase [IPR002306]", "TspO/MBR-related protein [IPR004307]", "Tubulin [IPR000217]", "Tubulin binding cofactor A [IPR004226]", "Tubulin--tyrosine ligase-like protein 12 [IPR027749]", "Tubulin-folding cofactor D [IPR033162]", "Tubulin-specific chaperone E [IPR044994]", "Tubulin-tyrosine ligase/Tubulin polyglutamylase [IPR004344]", "Tumor protein p53-inducible protein 11 [IPR028266]", "Tumour protein D52 [IPR007327]", "Tweety [IPR006990]", "Twinfilin [IPR028458]", "Twinkle-like protein [IPR027032]", "Type 1 protein exporter [IPR039421]", "Type II pantothenate kinase [IPR004567]", "Type II phosphatidylinositol 4-kinase Lsb6/PI4K2 [IPR039756]", "Tyrosine-tRNA ligase [IPR002307]", "Tyrosine-tRNA ligase, bacterial-type [IPR024088]", "Tyrosine/threonine-protein kinase, Cdc2 inhibitor [IPR016235]", "U1 small nuclear ribonucleoprotein C [IPR017340]", "U2 auxiliary factor small subunit [IPR009145]", "U2 small nuclear ribonucleoprotein A' [IPR044640]", "U2 snRNP auxilliary factor, large subunit, splicing factor [IPR006529]", "U3 small nucleolar RNA-associated protein 10 [IPR040191]", "U3 small nucleolar RNA-associated protein 18 [IPR045161]", "U3 small nucleolar RNA-associated protein 6 [IPR013949]", "U3 small nucleolar ribonucleoprotein complex, subunit Mpp10 [IPR012173]", "U3 snoRNP protein/Ribosome production factor 1 [IPR044281]", "U4/U6 small nuclear ribonucleoprotein Prp31 [IPR027105]", "U6 snRNA-associated Sm-like protein LSm2 [IPR016654]", "U6 snRNA-associated Sm-like protein Lsm3 [IPR040002]", "UAA transporter [IPR013657]", "UBAP2/protein lingerer [IPR022166]", "UBX domain-containing protein 2/7 [IPR017346]", "UDP-GlcNAc-dolichyl-phosphate GlcNAc phosphotransferase [IPR033895]", "UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110kDa subunit [IPR037919]", "UDP-glucose:Glycoprotein Glucosyltransferase [IPR009448]", "UDP-glucuronosyl/UDP-glucosyltransferase [IPR002213]", "UDP-sugar pyrophosphorylase [IPR039741]", "UDPGP family [IPR002618]", "UHRF1/2-like [IPR045134]", "UMP-CMP kinase [IPR006266]", "UPF0600 protein C5orf51 [IPR037657]", "USP39 [IPR033809]", "UTP--glucose-1-phosphate uridylyltransferase [IPR016267]", "UV excision repair protein Rad23 [IPR004806]", "Ubiquilin-1/2 [IPR028430]", "Ubiquinol-cytochrome-c reductase complex assembly factor 2 [IPR037698]", "Ubiquinone biosynthesis protein COQ9 [IPR012762]", "Ubiquitin binding protein, Hrs/VPS27 [IPR017073]", "Ubiquitin carboxyl-terminal hydrolase 10 [IPR028767]", "Ubiquitin carboxyl-terminal hydrolase 14-like [IPR044635]", "Ubiquitin conjugation factor E4 [IPR045132]", "Ubiquitin fusion degradation protein Ufd1-like [IPR004854]", "Ubiquitin thioesterase OTUB1 [IPR030298]", "Ubiquitin thioesterase Otubain [IPR016615]", "Ubiquitin-activating enzyme E1 [IPR018075]", "Ubiquitin-fold modifier 1 [IPR005375]", "Ubiquitin-fold modifier-conjugating enzyme 1 [IPR014806]", "Ubiquitin-like modifier-activating enzyme Atg7 [IPR006285]", "Ubiquitin-like-conjugating enzyme Atg3/Atg10 [IPR007135]", "Ubiquitin-protein ligase E3A [IPR017134]", "Ubiquitin/SUMO-activating enzyme E1 [IPR000011]", "Ubiquitinyl hydrolase [IPR016652]", "Ubiquitinyl hydrolase, UCH37 type [IPR017390]", "Ubiquitously expressed transcript protein UXT [IPR003994]", "Uncharacterised protein family, TMEM59 [IPR022065]", "Uncharacterized protein KIAA2013-like [IPR018795]", "Uracil-DNA glycosylase family 1 [IPR002043]", "Uridine kinase-like [IPR000764]", "Uridine-cytidine kinase 2 [IPR029925]", "Uroporphyrinogen decarboxylase HemE [IPR006361]", "V-type ATPase, V0 complex, 116kDa subunit family [IPR002490]", "V-type ATP synthase catalytic alpha chain [IPR022878]", "V-type ATP synthase regulatory subunit B/beta [IPR022879]", "V-type ATPase subunit E [IPR002842]", "V0 complex accessory subunit Ac45 [IPR008388]", "Vacuolar protein sorting protein 26 related [IPR028934]", "Vacuolar protein sorting-associated protein 13 [IPR026847]", "Vacuolar protein sorting-associated protein 16 [IPR016534]", "Vacuolar protein sorting-associated protein 29 [IPR028661]", "Vacuolar protein sorting-associated protein 33 [IPR027121]", "Vacuolar protein sorting-associated protein 35 [IPR005378]", "Vacuolar protein sorting-associated protein 4 [IPR031255]", "Vacuolar protein sorting-associated protein 51 [IPR014812]", "Vacuolar protein sorting-associated protein 53 [IPR039766]", "Vacuolar protein sorting-associated protein 9-like [IPR045046]", "Vacuolar protein sorting-associated protein Ist1 [IPR005061]", "Vacuolar protein-sorting protein Bro1-like [IPR045251]", "Valine-tRNA ligase [IPR002303]", "Vang-like protein [IPR009539]", "Vesicle transport protein, Got1/SFT2-like [IPR007305]", "Vesicle-associated membrane-protein-associated protein [IPR016763]", "Vesicle-fusing ATPase [IPR039812]", "Vesicle-trafficking protein Sec22 [IPR044565]", "Villin/Gelsolin [IPR007122]", "Vimentin [IPR027699]", "Vinculin [IPR017997]", "Vinculin/alpha-catenin [IPR006077]", "Vitamin K epoxide reductase complex subunit 1 [IPR042406]", "Vitamin K-dependent gamma-carboxylase [IPR007782]", "Voltage-dependent anion-selective channel protein 1 [IPR030270]", "Voltage-dependent anion-selective channel protein 2 [IPR030277]", "Voltage-dependent anion-selective channel protein 3 [IPR030271]", "Vps52 [IPR007258]", "WASH complex, subunit strumpellin [IPR019393]", "WD repeat BOP1/Erb1 [IPR028598]", "WD repeat Prp46/PLRG1-like [IPR045241]", "WD repeat WDR12/Ytm1 [IPR028599]", "WD repeat domain phosphoinositide-interacting protein 2 [IPR032911]", "WD repeat-containing protein 11 [IPR039694]", "WD repeat-containing protein 41 [IPR040102]", "WD repeat-containing protein DCAF7-like [IPR045159]", "WD repeat-containing protein WDR18/Ipi3/RID3 [IPR045227]", "WD repeat-containing protein WDR46/Utp7 [IPR040315]", "WD40 repeat-containing protein SMU1 [IPR045184]", "WDR48/Bun107 [IPR021772]", "WW domain binding protein 11 [IPR019007]", "WW domain-binding protein 2 [IPR033598]", "WW domain-binding protein 2-like [IPR044852]", "Wings apart-like protein [IPR039874]", "Wolframin [IPR026208]", "Wolframin family [IPR026209]", "XAP5 protein [IPR007005]", "XMAP215 family [IPR045110]", "XPG/Rad2 endonuclease [IPR006084]", "Xaa-Arg dipeptidase [IPR017144]", "YAP-binding/ALF4/Glomulin [IPR013877]", "YIP1 family member 3 [IPR026637]", "YLP motif-containing protein 1 [IPR026314]", "YTH domain containing protein [IPR045168]", "Yif1 family [IPR005578]", "YjeF N-terminal domain-containing protein NAXE-like [IPR032976]", "YjgF/YER057c/UK114 family [IPR006175]", "ZPR1 family [IPR040141]", "ZW10 interactor [IPR029092]", "Zinc finger CCHC domain-containing protein 3 [IPR042509]", "Zinc finger CCHC-type and RNA-binding motif-containing protein 1 [IPR044598]", "Zinc finger FYVE domain containing protein, SARA/endofin [IPR035438]", "Zinc finger FYVE domain-containing protein, endofin [IPR017165]", "Zinc finger Ran-binding domain-containing protein 2 [IPR017337]", "Zinc finger protein 622/Rei1/Reh1 [IPR040025]", "Zinc finger protein 638 [IPR033096]", "Zinc transporter Msc2-like [IPR045316]", "Zinc/iron permease [IPR003689]", "cAMP-dependent protein kinase catalytic subunit [IPR044109]", "cAMP-dependent protein kinase regulatory subunit [IPR012198]", "dCTP pyrophosphatase 1 [IPR025984]", "dTDP-4-dehydrorhamnose reductase family [IPR005913]", "hnRNP A2/B1 [IPR034489]", "mRNA 3'-end-processing protein Rna14-like [IPR045243]", "mRNA export factor Gle2/RAE1 [IPR037631]", "mRNA-decapping enzyme subunit 1 [IPR010334]", "p53 tumour suppressor family [IPR002117]", "rRNA biogenesis protein RRP36 [IPR009292]", "rRNA biogenesis protein Rrp5 [IPR045209]", "tRNA (C5-cytosine) methyltransferase, NCL1 [IPR023270]", "tRNA (guanine-N1-)-methyltransferase, eukaryotic [IPR007356]", "tRNA (uracil(54)-C(5))-methyltransferase, eukaryotic type [IPR045850]", "tRNA N6-adenosine threonylcarbamoyltransferase Kae1, archaea and eukaryote [IPR034680]", "tRNA guanosine-2'-O-methyltransferase, TRM11 [IPR016691]", "tRNA methyltransferase 10 homologue C [IPR025812]", "tRNA methyltransferase, Trm1 [IPR002905]", "tRNA modification GTPase MnmE [IPR004520]", "tRNA pseudouridine synthase B family [IPR004802]", "tRNA pseudouridine synthase II, TruB [IPR014780]", "tRNA-specific 2-thiouridylase [IPR004506]"], "available_proteins": ["AAAS", "AAR2", "AARS", "AARS2", "AATF", "ABCB1", "ABCB7", "ABCC1", "ABCD3", "ABCE1", "ABHD12", "ABHD6", "ABI1", "ACAA2", "ACADM", "ACAT1", "ACAT2", "ACBD5", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOX1", "ACOX3", "ACP1", "ACP2", "ACP6", "ACSL1", "ACTL6A", "ACTR10", "ACTR1A", "ACTR1B", "ACTR2", "ACTR3", "ADD1", "ADD3", "ADH5", "ADI1", "ADNP", "ADPGK", "ADPRHL2", "ADRM1", "ADSL", "ADSS", "AFG3L2", "AGL", "AGPS", "AHCY", "AHCYL1", "AHSA1", "AIMP2", "AIP", "AK1", "AK2", "AKAP12", "AKAP13", "AKAP8", "AKAP8L", "AKR1A1", "AKR1B1", "ALDH18A1", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDOA", "ALDOC", "ALG1", "ALG11", "ALG12", "ALKBH5", "AMOT", "ANAPC1", "ANAPC16", "ANAPC2", "ANAPC5", "ANKLE2", "ANO10", "ANO6", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA3", "ANXA4", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP1M1", "AP1S2", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "AP3S1", "APEX1", "API5", "APLP2", "APOL2", "APOO", "APOOL", "APP", "APRT", "AQR", "ARCN1", "ARF4", "ARF6", "ARFIP1", "ARFIP2", "ARGLU1", "ARHGDIA", "ARID1A", "ARID3B", "ARIH1", "ARIH2", "ARL1", "ARL10", "ARL2", "ARL3", "ARL6IP1", "ARL6IP5", "ARL6IP6", "ARMC6", "ARMC8", "ARMT1", "ARPC1A", "ARPC2", "ARPC3", "ARPC4", "ARPC5", "ASAH1", "ASNA1", "ASNS", "ASPH", "ATAD2", "ATAD3A", "ATAD3B", "ATE1", "ATG3", "ATG4B", "ATG7", "ATG9A", "ATIC", "ATP13A1", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6", "ATP6AP1", "ATP6AP2", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1D", "ATP6V1E1", "ATP6V1H", "ATP7B", "ATPAF1", "ATPIF1", "ATRIP", "ATXN2L", "AURKA", "AURKB", "B3GALT6", "B4GAT1", "BABAM1", "BAG2", "BAG4", "BAG5", "BAIAP2", "BAK1", "BANF1", "BANP", "BASP1", "BCAP31", "BCAS2", "BCCIP", "BCL2L13", "BCLAF1", "BICD2", "BIRC6", "BLMH", "BLVRA", "BMS1", "BNIP1", "BOD1", "BOLA2*", "BOP1", "BPNT1", "BRAT1", "BRI3BP", "BRIX1", "BSG", "BTAF1", "BTF3", "BUB1B", "BUD23", "BUD31", "BYSL", "C11orf58", "C12orf73", "C16orf58", "C17orf75", "C19orf70", "C1QBP", "C1orf35", "C21orf59", "C2CD5", "C5orf51", "CAB39", "CACUL1", "CAD", "CALD1", "CALR", "CALU", "CAND1", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPRIN1", "CAPZA1", "CAPZA2", "CAPZB", "CARM1", "CARS", "CARS2", "CAST", "CBR1", "CBX3", "CCAR1", "CCAR2", "CCDC124", "CCDC134", "CCDC138", "CCDC22", "CCDC47", "CCDC6", "CCDC86", "CCNB1", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2AP", "CD2BP2", "CD47", "CDC123", "CDC20", "CDC37", "CDC40", "CDC42", "CDC73", "CDCA2", "CDCA8", "CDH2", "CDIPT", "CDK5RAP3", "CDK6", "CDKAL1", "CDS2", "CEBPZ", "CECR2", "CELF2", "CENPI", "CENPP", "CEP290", "CEP44", "CEP55", "CERS1", "CERS2", "CETN2", "CFAP20", "CFL1", "CFL2", "CHAC2", "CHAF1A", "CHAF1B", "CHAMP1", "CHCHD3", "CHD1L", "CHERP", "CHMP1A", "CHMP2A", "CHMP2B", "CHMP3", "CHMP4B", "CHMP5", "CHMP7", "CHORDC1", "CHST14", "CIAPIN1", "CIP2A", "CISD1", "CISD2", "CKAP2", "CKAP4", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLCC1", "CLCN3", "CLCN7", "CLGN", "CLIC1", "CLIC4", "CLINT1", "CLN5", "CLNS1A", "CLPB", "CLPP", "CLPTM1", "CLPTM1L", "CLPX", "CLTA", "CLTC", "CLU", "CLUH", "CMAS", "CMPK1", "CMSS1", "CMTR1", "CNDP2", "CNN3", "CNNM3", "CNNM4", "CNOT1", "CNOT10", "CNOT11", "CNOT2", "CNOT9", "CNP", "CNPY2", "COA3", "COA7", "COASY", "COG3", "COIL", "COLGALT1", "COMMD1", "COMT", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS7A", "COPS8", "COPZ1", "COQ8A", "COQ9", "CORO1B", "CORO1C", "CORO7", "COTL1", "COX18", "COX2", "COX4I1", "COX5A", "COX5B", "COX6C", "COX7A2", "CPD", "CPNE1", "CPNE3", "CPOX", "CPSF2", "CPSF6", "CPSF7", "CPT1A", "CPT2", "CPVL", "CRNKL1", "CROT", "CRTAP", "CRYZL1", "CS", "CSNK2A2", "CSNK2B", "CSTB", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTNNA1", "CTNNAL1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTPS2", "CTR9", "CTSA", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CUTA", "CWC15", "CWC27", "CWF19L1", "CXorf56", "CXorf57", "CYB5R1", "CYB5R3", "CYC1", "CYFIP1", "CYFIP2", "CYP20A1", "CYP51A1", "DAD1", "DAP3", "DARS", "DARS2", "DAXX", "DBN1", "DBNL", "DCAF16", "DCAF7", "DCAKD", "DCD", "DCP1B", "DCPS", "DCTD", "DCTN2", "DCTN3", "DCTN4", "DCTPP1", "DCUN1D1", "DCUN1D5", "DCXR", "DDAH2", "DDB1", "DDOST", "DDRGK1", "DDT", "DDX54", "DEGS1", "DEK", "DENR", "DERL1", "DERL2", "DFFA", "DGKE", "DHCR24", "DHCR7", "DHFR", "DHPS", "DHRS1", "DHRS4", "DHRS7", "DHRS7B", "DHX29", "DIABLO", "DIAPH1", "DIAPH2", "DIAPH3", "DIDO1", "DIMT1", "DKC1", "DLAT", "DLD", "DLG3", "DLGAP5", "DLST", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJC10", "DNAJC13", "DNAJC2", "DNAJC8", "DNM1L", "DNM2", "DNMT1", "DNPH1", "DNTTIP2", "DOCK7", "DOHH", "DOLPP1", "DPAGT1", "DPH2", "DPH5", "DPM1", "DPP3", "DPYSL2", "DPYSL5", "DRG1", "DRG2", "DSC3", "DSG2", "DSP", "DST", "DSTN", "DTYMK", "DUSP12", "DUSP3", "DUSP9", "DUT", "DYM", "DYNC1I2", "DYNC1LI1", "DYNC1LI2", "DYNLL2", "EARS2", "EBNA1BP2", "ECD", "ECE1", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "ECSIT", "EDC4", "EEF1A2", "EEF1E1", "EEF1G", "EFCAB14", "EHD1", "EHD4", "EIF2A", "EIF2B1", "EIF2B2", "EIF2D", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4B", "EIF4E", "EIF4G1", "EIF4G2", "EIF4G3", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAVL1", "ELMO2", "ELMOD2", "ELOA", "ELOB", "ELOC", "ELP1", "ELP2", "ELP3", "EMC1", "EMC2", "EMC4", "EMC7", "EMD", "EMG1", "ENDOD1", "ENO1", "ENO2", "ENOPH1", "EPB41", "EPB41L2", "EPB41L3", "EPB41L5", "EPDR1", "EPHA7", "EPHX1", "EPHX2", "EPPK1", "EPRS", "ERAL1", "ERAP1", "ERC1", "ERCC2", "ERCC3", "ERGIC2", "ERGIC3", "ERH", "ERLIN1", "ERLIN2", "ERMP1", "ERO1A", "ERP29", "ESD", "ESF1", "ESPL1", "ETF1", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXO1", "EXOC2", "EXOC3", "EXOC5", "EXOC6", "EXOC6B", "EXOC7", "EXOC8", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC9", "EZR", "F11R", "FABP5", "FADS2", "FAH", "FAM114A2", "FAM162A", "FAM177A1", "FAM192A", "FAM210A", "FAM213A", "FAM3C", "FAM49B", "FAM50A", "FAM98A", "FAM98B", "FANCD2", "FANCI", "FAR1", "FARP1", "FARS2", "FARSA", "FARSB", "FAU", "FBL", "FDFT1", "FDPS", "FDXR", "FECH", "FEN1", "FERMT2", "FH", "FHL1", "FHOD1", "FIS1", "FKBP2", "FKBP3", "FKBP4", "FKBP5", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FMR1", "FN3KRP", "FNTB", "FSCN1", "FTL", "FTO", "FTSJ3", "FUCA1", "FUCA2", "FUNDC2", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GADD45GIP1", "GAL", "GALK1", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GATAD2B", "GBA", "GBE1", "GCAT", "GCLC", "GCN1", "GDAP1", "GDI1", "GDI2", "GEMIN4", "GET4", "GFM1", "GFPT1", "GGCT", "GGCX", "GGH", "GGPS1", "GHDC", "GHITM", "GINS2", "GINS3", "GINS4", "GLA", "GLB1", "GLDC", "GLG1", "GLMN", "GLO1", "GLOD4", "GLRX3", "GLS", "GLT8D1", "GLUD1", "GM2A", "GMFB", "GNA13", "GNAI2", "GNAI3", "GNG12", "GNL2", "GNPAT", "GNPDA1", "GNS", "GOLGA2", "GOLGA3", "GOLGA5", "GOLGB1", "GOLIM4", "GOLM1", "GOLPH3", "GOLT1B", "GOPC", "GORASP2", "GOSR1", "GOT1", "GOT2", "GPAA1", "GPAM", "GPD2", "GPHN", "GPI", "GPKOW", "GPR107", "GPR89B", "GPS1", "GPT2", "GRIPAP1", "GRPEL1", "GRSF1", "GSR", "GSS", "GSTK1", "GSTM3", "GSTO1", "GTF2B", "GTF2E1", "GTF2F1", "GTF2I", "GTF3C1", "GTF3C3", "GTPBP1", "GTPBP10", "GTPBP3", "GTPBP4", "GUF1", "GYG1", "GYS1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACD2", "HACD3", "HACL1", "HADH", "HADHA", "HADHB", "HAT1", "HAUS1", "HAUS3", "HAUS4", "HAUS5", "HCCS", "HCFC1", "HDAC1", "HDAC2", "HDHD2", "HDHD5", "HEATR1", "HEBP1", "HEBP2", "HECTD1", "HEXA", "HEXB", "HGH1", "HGS", "HIBADH", "HIBCH", "HIKESHI", "HINT2", "HIRIP3", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HM13", "HMBS", "HMCES", "HMGA1", "HMGB1", "HMGB3", "HMGCL", "HMGCR", "HMGCS1", "HMGN2", "HMMR", "HMOX1", "HMOX2", "HNRNPA1", "HNRNPA2B1", "HNRNPC", "HNRNPK", "HNRNPL", "HNRNPLL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HP1BP3", "HPRT1", "HPS6", "HS2ST1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSDL1", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA13", "HSPA14", "HSPA1B", "HSPA2", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPB1", "HSPD1", "HSPE1", "HSPH1", "HTATSF1", "HTRA2", "HUS1", "HYOU1", "IARS", "IARS2", "ICMT", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDI1", "IFT27", "IGF2BP2", "IK", "IKBIP", "ILF3", "ILKAP", "ILVBL", "IMMT", "IMP3", "IMP4", "IMPA1", "IMPAD1", "IMPDH1", "IMPDH2", "INA", "INCENP", "INTS14", "INTS3", "INTS7", "IPO4", "IPO5", "IRGQ", "IRS4", "IST1", "ITCH", "ITGB1", "ITM2C", "ITPA", "IVD", "JAGN1", "JPT2", "JUP", "KARS", "KDELR1", "KDM1A", "KDM3B", "KDSR", "KHDRBS1", "KIAA0319L", "KIAA0368", "KIAA0391", "KIAA1147", "KIAA1468", "KIAA2013", "KIF14", "KIF15", "KIF18B", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF5B", "KIFBP", "KIN", "KLC1", "KLC2", "KLC4", "KMT2A", "KPNA1", "KPNA2", "KPNA3", "KPNA6", "KPNB1", "KRI1", "KRR1", "KTN1", "L1RE1", "LAMP1", "LAMP2", "LAMTOR1", "LANCL2", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LAS1L", "LBR", "LDAH", "LDHA", "LDHB", "LEMD2", "LEMD3", "LETM1", "LGMN", "LIG1", "LIG3", "LIMA1", "LIPA", "LMF2", "LNPEP", "LNPK", "LONP1", "LPCAT3", "LRPAP1", "LRPPRC", "LRRC47", "LSM12", "LSM2", "LSM3", "LSM4", "LSM6", "LSM7", "LSS", "LTA4H", "LTV1", "LUC7L", "LUC7L2", "LYAR", "LYSMD3", "LZIC", "LZTFL1", "M6PR", "MACF1", "MAD2L1", "MAGED2", "MAGT1", "MAK16", "MAN1A1", "MANF", "MAP1B", "MAP1S", "MAP4", "MAPK1", "MAPK14", "MAPRE1", "MAPRE2", "MARS", "MAT2A", "MAT2B", "MAU2", "MAVS", "MBD3", "MBOAT7", "MCCC2", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCMBP", "MCTS1", "MCU", "MCUR1", "MDH1", "MDH2", "MDN1", "ME1", "ME2", "MECP2", "MED21", "MED23", "MED24", "MED25", "MEPCE", "METAP2", "METTL14", "METTL3", "METTL9", "MFN1", "MFN2", "MFSD3", "MFSD5", "MGEA5", "MGST2", "MGST3", "MICU1", "MICU2", "MIF", "MINDY3", "MIPEP", "MKRN2", "MLEC", "MMAB", "MMS19", "MOB4", "MOGS", "MORF4L1", "MOV10", "MPC2", "MPDU1", "MPG", "MPHOSPH10", "MPI", "MPST", "MPV17", "MPV17L2", "MRE11", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL14", "MRPL15", "MRPL17", "MRPL19", "MRPL21", "MRPL22", "MRPL23", "MRPL24", "MRPL28", "MRPL3", "MRPL37", "MRPL38", "MRPL40", "MRPL44", "MRPL46", "MRPL50", "MRPL53", "MRPL55", "MRPL9", "MRPS11", "MRPS15", "MRPS16", "MRPS18A", "MRPS22", "MRPS23", "MRPS25", "MRPS27", "MRPS30", "MRPS31", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRPS9", "MRRF", "MRTO4", "MSH2", "MSH3", "MSH6", "MSN", "MTA1", "MTA2", "MTAP", "MTBP", "MTDH", "MTFP1", "MTHFD1", "MTHFD1L", "MTHFD2", "MTMR14", "MTMR2", "MTOR", "MTR", "MTX1", "MTX2", "MVK", "MYBBP1A", "MYCBP", "MYDGF", "MYEF2", "MYG1", "NAA15", "NAA25", "NAA35", "NAA40", "NADK2", "NAE1", "NAF1", "NAGA", "NAGLU", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NAPG", "NARS", "NAT10", "NAXE", "NCAPD2", "NCAPD3", "NCAPG", "NCAPG2", "NCAPH", "NCBP1", "NCBP3", "NCDN", "NCKAP1", "NCLN", "NCSTN", "ND1", "NDC1", "NDUFA13", "NDUFA4", "NDUFAF3", "NDUFAF7", "NDUFB10", "NDUFB4", "NDUFB5", "NDUFB6", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS7", "NDUFS8", "NDUFV1", "NDUFV2", "NEFL", "NEFM", "NELFCD", "NELFE", "NES", "NGDN", "NHP2", "NIP7", "NLN", "NME1", "NMT1", "NNT", "NOB1", "NOC2L", "NOC3L", "NOC4L", "NOL10", "NOL11", "NOL6", "NOL7", "NOL9", "NOP14", "NOP16", "NOP2", "NOP53", "NOP56", "NOP58", "NOP9", "NOSIP", "NPC1", "NPC2", "NPEPPS", "NPLOC4", "NPM1", "NSA2", "NSF", "NSMCE2", "NSUN2", "NSUN5", "NT5C2", "NT5C3B", "NT5DC1", "NT5DC2", "NTHL1", "NTMT1", "NTPCR", "NUB1", "NUBP2", "NUBPL", "NUCB1", "NUCB2", "NUCKS1", "NUDC", "NUDCD1", "NUDCD2", "NUDT1", "NUDT21", "NUDT9", "NUFIP2", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP160", "NUP188", "NUP205", "NUP210", "NUP214", "NUP35", "NUP37", "NUP50", "NUP54", "NUP58", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NUTF2", "NXF1", "OAT", "OCIAD1", "OCLN", "OGDH", "OGT", "OLA1", "OPA1", "OPA3", "OSBP", "OSBPL3", "OSBPL6", "OSBPL8", "OSBPL9", "OSGEP", "OTUB1", "OXA1L", "OXCT1", "OXSR1", "P3H1", "P3H4", "P4HA1", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PAF1", "PAFAH1B1", "PAIP2", "PAK2", "PANK4", "PAPOLA", "PARG", "PARK7", "PARN", "PATL1", "PAWR", "PBDC1", "PBRM1", "PC", "PCBD1", "PCID2", "PCK2", "PCLAF", "PCM1", "PCMT1", "PCNA", "PCNP", "PCYOX1", "PDAP1", "PDCD11", "PDCD5", "PDCD6IP", "PDE6D", "PDHA1", "PDHB", "PDIA3", "PDIA4", "PDIA6", "PDK3", "PDLIM1", "PDS5A", "PDS5B", "PDXDC1", "PDXK", "PEBP1", "PECR", "PELO", "PES1", "PEX11A", "PEX14", "PEX16", "PEX19", "PEX5", "PFAS", "PFDN2", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGM3", "PGP", "PHAX", "PHB", "PHB2", "PHF5A", "PHGDH", "PHIP", "PHKA1", "PI4K2A", "PI4KB", "PIBF1", "PICALM", "PIGK", "PIGS", "PIGT", "PIGU", "PIK3R4", "PIN4", "PIP4K2C", "PIR", "PISD", "PITHD1", "PITPNB", "PKM", "PKMYT1", "PLA2G15", "PLBD2", "PLCG1", "PLEC", "PLIN3", "PLPBP", "PLRG1", "PLS3", "PM20D2", "PMF1", "PMPCA", "PMPCB", "PMVK", "PNKP", "PNN", "PNO1", "PNP", "PNPT1", "PODXL", "POFUT1", "POLA1", "POLA2", "POLD1", "POLD2", "POLD3", "POLE", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2A", "POLR2B", "POLR2D", "POLR2E", "POLR2F", "POLR2G", "POLR2L", "POLR3A", "POLR3C", "POLRMT", "PON2", "POP1", "POR", "PPA1", "PPA2", "PPAN", "PPAT", "PPIH", "PPIL1", "PPIL3", "PPIL4", "PPM1G", "PPME1", "PPOX", "PPP1CA", "PPP1R12A", "PPP2R1A", "PPP2R2A", "PPP2R5D", "PPP2R5E", "PPP3CA", "PPP4R1", "PPP5C", "PPP6R3", "PPT1", "PPT2", "PPWD1", "PRAF2", "PRC1", "PRCC", "PRCP", "PRDX2", "PRDX5", "PRDX6", "PREB", "PREP", "PREPL", "PRIM1", "PRIM2", "PRKACA", "PRKAG1", "PRKAR1A", "PRKAR2A", "PRKCB", "PRKCSH", "PRKRA", "PRMT1", "PRMT3", "PRMT5", "PRMT9", "PRPF19", "PRPF31", "PRPF38B", "PRPF40A", "PRPF6", "PRPF8", "PRPSAP1", "PRPSAP2", "PRRC1", "PRRC2A", "PRRC2C", "PRTFDC1", "PSAP", "PSAT1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD6", "PSMD7", "PSMD8", "PSMD9", "PSME1", "PSME2", "PSME3", "PSME4", "PSMG1", "PTBP1", "PTCD3", "PTDSS1", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTPA", "PTPMT1", "PTPN1", "PTPN11", "PTRH2", "PUDP", "PUF60", "PUM3", "PURA", "PUS7", "PWP1", "PWP2", "PXMP2", "PXN", "PYCR1", "PYCR2", "PYCR3", "PYGB", "PYGL", "QARS", "QKI", "QRSL1", "QSOX2", "QTRT2", "RAB10", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB1B", "RAB21", "RAB24", "RAB31", "RAB39A", "RAB3GAP1", "RAB3GAP2", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RAB8A", "RAB9A", "RABAC1", "RABEP1", "RABGAP1", "RABL6", "RAC1", "RACK1", "RAD21", "RAD23A", "RAD23B", "RAD50", "RAE1", "RAI14", "RALA", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP6", "RAP2B", "RAPGEF2", "RARS", "RARS2", "RAVER1", "RBBP5", "RBBP6", "RBM10", "RBM17", "RBM22", "RBM26", "RBM27", "RBM39", "RBM5", "RBM6", "RBM8A", "RBP1", "RCC2", "RCL1", "RDH11", "RDH13", "RDH14", "RDX", "RECQL", "REEP4", "REEP5", "RER1", "RETREG3", "REXO4", "RFC1", "RFT1", "RHEB", "RHOG", "RHOT1", "RHOT2", "RIDA", "RIF1", "RINT1", "RMC1", "RNASEH2A", "RNASET2", "RNF14", "RNF20", "RNF219", "RNF40", "RNPEP", "ROCK1", "RPA1", "RPA2", "RPAP1", "RPF1", "RPF2", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPN1", "RPN2", "RPP30", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS28", "RPS29", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RPTOR", "RRBP1", "RRM1", "RRM2", "RRP1", "RRP15", 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b/interpro_homologous_superfamily/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:a9de4044befd5eb117b41b4dab323885b9ed4bfee57f59e43dccc74f41f1cf31 +size 144738 diff --git a/interpro_homologous_superfamily/df_merge.tsv b/interpro_homologous_superfamily/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..e58b7f736691afd29f24ba119a40ace4f81fd0ba --- /dev/null +++ b/interpro_homologous_superfamily/df_merge.tsv @@ -0,0 +1,11 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Mitochondrial carrier domain superfamily [IPR023395] 22 23 3.857387164934564 0.0001146055556109 9.148058252427184 20.71359223300971 2.0411027534642088 0.1411881998864352 5.368907349966936 1.8276489510009888 1.309103123363054 0.2428184236965967 2.7244366583104737e-12 0.0007818203448131 0.0004434091565531 1.2429151463024507e-08 4.266527055835198e-12 +EF-hand domain pair [IPR011992] 15 47 2.823554656338241 0.0047494327226367 13.3252427184466 49.37378640776699 0.9065364020670126 0.4404331516970506 4.9772339658485505 4.730718887980642 1.169914018421813 0.3730081256676846 0.0002273708099723 0.1241751068215353 0.3411482975481839 0.0032139778119164 0.0003165416418118 +Glycoside hydrolase superfamily [IPR017853] 7 16 2.472154673021536 0.0134301395507772 7.094660194174757 15.565533980582524 0.5992585613623983 0.1928722204186086 2.565315823223627 1.245604487832095 1.9386029676344616 0.2695693578719223 1.4163650158743628e-05 0.1178616319260966 0.2202973788945578 0.4649111194254866 1.7549530446416166e-05 +SNARE [IPR010989] 4 6 2.237097663552904 0.0252799576448548 2.4854368932038833 5.364077669902913 0.7966086592831925 0.3585374753437345 1.5079985943563208 1.7302199405020957 1.098385457365192 0.3157194502762394 0.0346431338005326 1.0 0.1419203898220533 0.3192924621263296 0.0373405153007746 +Cytochrome b5-like heme/steroid binding domain superfamily [IPR036400] 4 6 2.1687478005237395 0.0301018361917864 2.813106796116505 6.104368932038835 1.6405397264547834 0.1100883340733615 1.2852875686886795 0.8042848477475721 1.100790504333474 0.1612592696854457 0.000122001793767 0.0561990347849709 0.0055563644779973 0.0024789777341693 0.0001402534450405 +P-type ATPase, cytoplasmic domain N [IPR023299] 4 5 2.063733772997012 0.039042965342845 2.941747572815534 6.145631067961165 0.9567723497044874 0.2732808833570771 1.8358630293390923 1.459204245106796 1.2102525517005158 0.2943240638910574 0.0167170186699105 1.0 1.0 0.4108142183097444 0.0184399659986801 +P-type ATPase, A domain superfamily [IPR008250] 4 5 2.063733772997012 0.039042965342845 2.941747572815534 6.145631067961165 0.9567723497044874 0.2732808833570771 1.8358630293390923 1.459204245106796 1.2102525517005158 0.2943240638910574 0.0167170186699105 1.0 1.0 0.4108142183097444 0.0184399659986801 +P-type ATPase, transmembrane domain superfamily [IPR023298] 4 5 2.063733772997012 0.039042965342845 2.941747572815534 6.145631067961165 0.9567723497044874 0.2732808833570771 1.8358630293390923 1.459204245106796 1.2102525517005158 0.2943240638910574 0.0195192259352808 1.0 1.0 0.4248286628842983 0.0215080214882775 +Band 7/SPFH domain superfamily [IPR036013] 7 8 2.034318154650474 0.0419195279005741 3.825242718446602 7.354368932038835 0.2848798017769268 0.3662852929750465 1.8717479731706237 0.7075565364256523 1.25010454777189 0.3076860385713043 0.0091083435026884 1.0 1.0 1.0 0.0098775035556596 +Tim10-like domain superfamily [IPR035427] 3 5 1.9892556971379796 0.0466729870130147 1.2005141388174807 2.5167095115681235 0.6297728943083764 0.3036466482483842 1.011959204869136 1.1903007636326162 1.51035532787006 0.2968335314780513 0.0017428204603846 1.0 0.0557540441617295 0.1342523552784823 0.001897897013483 diff --git a/interpro_homologous_superfamily/metrics.json b/interpro_homologous_superfamily/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..9dfe911f0a1907e32e0f9298d4d8de1faae9e1dd --- /dev/null +++ b/interpro_homologous_superfamily/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2974, + "annotations_size": 948, + "title": "Average number of proteins per term", + "value": 4.562236286919831 +} \ No newline at end of file diff --git a/interpro_homologous_superfamily/paths.json b/interpro_homologous_superfamily/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..a8eaab12842413f78880796f4efc40c005f5fbdd --- /dev/null +++ b/interpro_homologous_superfamily/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/interpro_homologous_superfamily/fragment/C220/C220_val_log2fc"} \ No newline at end of file diff --git a/interpro_homologous_superfamily/result.tsv b/interpro_homologous_superfamily/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..3684dc47923380eb9d16e779e1771f873c8fbf9f --- /dev/null +++ b/interpro_homologous_superfamily/result.tsv @@ -0,0 +1,117 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Mitochondrial carrier domain superfamily [IPR023395] 0.7587258556421699 3.857387164934564 0.0001146055556109 0.1029577287696954 0.1086460667191682 23 Q9HC21,Q9UJS0,Q70HW3,Q9UBX3,P05141,O43772,Q9NZJ7,Q9H2D1,Q00325,Q9H936,Q9Y6C9,Q02978,Q9BQT8,P12236,Q9Y619,O75746,Q9BSK2,Q86VD7,Q6NUK1,O43808,P12235,P53007 22 +EF-hand domain pair [IPR011992] 0.5189103987521185 2.823554656338241 0.0047494327226367 0.9890365500111838 0.1708466806625338 47 Q9Y680,O43852,Q02818,Q9UJS0,O75071,Q8IYU8,O95202,Q96AY3,Q8NF37,Q9NWM8,O95302,Q9BRK5,Q6NUK1,Q14257,P80303 15 +Glycoside hydrolase superfamily [IPR017853] 0.640933828469806 2.4721546730215356 0.0134301395507772 0.9999972885860284 0.1708466806625338 16 P17050,P04062,P54802,P06280,P10253,Q9BTY2,P16278 7 +SNARE [IPR010989] 0.804898706686981 2.2370976635529036 0.0252799576448548 0.9999999999712827 0.1903336807880789 6 Q86Y82,Q12846,Q13190,O60499 4 +Cytochrome b5-like heme/steroid binding domain superfamily [IPR036400] 0.7900241226067679 2.1687478005237395 0.0301018361917864 0.9999999999997392 0.2004853742311554 6 O43169,O15173,O00264,O95864 4 +P-type ATPase, cytoplasmic domain N [IPR023299] 0.8174469518356344 2.063733772997012 0.039042965342845 1.0 0.2237426322907464 5 P35670,P05023,Q9HD20,P16615 4 +P-type ATPase, A domain superfamily [IPR008250] 0.8174469518356344 2.063733772997012 0.039042965342845 1.0 0.2237426322907464 5 P35670,P05023,Q9HD20,P16615 4 +P-type ATPase, transmembrane domain superfamily [IPR023298] 0.8174469518356344 2.063733772997012 0.039042965342845 1.0 0.2237426322907464 5 P35670,P05023,Q9HD20,P16615 4 +Band 7/SPFH domain superfamily [IPR036013] 0.7346594740391011 2.034318154650474 0.0419195279005741 1.0 0.2307364393489579 8 Q14254,Q9UJZ1,P27105,P35232,Q99623,O75477,O75955 7 +START-like domain superfamily [IPR023393] 0.8717800318396367 2.0062865165520383 0.0448256877647286 1.0 0.236081955560904 4 Q14849 1 +Tim10-like domain superfamily [IPR035427] 0.8007719439061067 1.9892556971379791 0.0466729870130147 1.0 0.2388948795624465 5 Q9Y5J9,Q9Y5J6,Q9Y5J7 3 +Porin domain superfamily [IPR023614] 0.862289562289575 1.966231617392919 0.0492718618059306 1.0 0.2439200480911543 4 P45880,P21796,Q9Y277 3 +LEM/LEM-like domain superfamily [IPR011015] 0.7426594526830846 1.9475700479836804 0.0514664305740926 1.0 0.2502060317140502 6 P42167,Q86XL3 2 +ABC transporter type 1, transmembrane domain superfamily [IPR036640] 0.7878073425395749 1.9309641692697916 0.053487483608904 1.0 0.2542351843292934 5 P08183,O75027,Q03518,P33527 4 +FAD/NAD(P)-binding domain superfamily [IPR036188] 0.5052781558546456 1.8504972121047016 0.0642419194877454 1.0 0.2886319415847522 19 Q9H9P8,Q6NUM9,Q8NB78,O95831,Q9UHG3,Q14534,Q96CU9 7 +Haem oxygenase-like, multi-helical [IPR016084] 0.9639973082099615 1.8123112424761223 0.0699381183961331 1.0 0.3041345699061204 2 P30519 1 +Glycosyl hydrolase, all-beta [IPR013780] 0.6280756607837854 1.79546680265288 0.0725793573639439 1.0 0.3068373400810871 10 P06280,P10253,Q9BTY2 3 +Tetraspanin, EC2 domain superfamily [IPR008952] 0.9596095590710167 1.7379756989008786 0.0822150958146266 1.0 0.323064473583113 3 O60637,O43657 2 +GOLD domain superfamily [IPR036598] 0.800322960377083 1.701253850337889 0.0888953298246362 1.0 0.3330991454759934 4 Q15363 1 +Cation efflux transmembrane domain superfamily [IPR027469] 0.9377523553162888 1.7012464818771558 0.0888967128749222 1.0 0.3330991454759934 2 Q6NXT4 1 +Immunoglobulin-like domain superfamily [IPR036179] 0.6084428732481896 1.6859094745423766 0.0918132367723809 1.0 0.3380068104437738 10 P01889,P35613,P10321,P04439,Q08722 5 +MFS transporter superfamily [IPR036259] 0.6634438606625217 1.679175113359373 0.093117920656135 1.0 0.3380068104437738 8 P53985,O00400,Q7L0J3,P41440,Q96ES6 5 +GMP phosphodiesterase, delta subunit superfamily [IPR037036] 0.9414338606529752 1.666093155292813 0.0956948616304087 1.0 0.3380068104437738 3 Q13432,A6NIH7 2 +Cytochrome P450 superfamily [IPR036396] 0.9286675639300144 1.6626958580221347 0.0963733317476052 1.0 0.3380068104437738 2 Q16850 1 +Ricin B-like lectins [IPR035992] 0.785295907070943 1.6361759379846317 0.1018027708155777 1.0 0.347653404474058 4 Q8N4A0 1 +Rhomboid-like superfamily [IPR035952] 0.9256142712891248 1.6033328451582325 0.1088611886777908 1.0 0.3542433124302839 3 Q6NTF9,Q9GZP9 2 +DHS-like NAD/FAD-binding domain superfamily [IPR029035] 0.6564645609246089 1.5320057062432308 0.125521026638709 1.0 0.3801723107140451 6 A1L0T0 1 +Importin-alpha, importin-beta-binding domain superfamily [IPR036975] 0.745869765291504 1.4642024687297417 0.1431386359039252 1.0 0.3991041965791799 4 O00505 1 +Membrane associated eicosanoid/glutathione metabolism-like domain superfamily [IPR023352] 0.8792059219380897 1.452263305358476 0.14642840637678 1.0 0.403529445480196 2 Q99735 1 +MHC class I-like antigen recognition-like superfamily [IPR037055] 0.7321323440019449 1.4039450062793386 0.1603352262448272 1.0 0.4210465221055296 4 P10321,P04439 2 +MHC classes I/II-like antigen recognition protein [IPR011162] 0.7321323440019449 1.4039450062793386 0.1603352262448272 1.0 0.4210465221055296 4 P10321,P04439 2 +Alpha/Beta hydrolase fold [IPR029058] 0.4241402983565308 1.3988212251252656 0.1618665997620605 1.0 0.4238937474431861 24 Q9H3G5,P42785,P10619,Q8NCC3,Q9UMR5,P07099,Q9HB40,P49327,P50897,Q9H6V9,Q9NUJ1,Q4J6C6 12 +NAP-like superfamily [IPR037231] 0.8714237630427369 1.387410155598069 0.1653167300106317 1.0 0.4308624111082223 3 Q01105,P55209 2 +FAD-binding, type PCMH, subdomain 2 [IPR016169] 0.8519515477792816 1.3362917150068694 0.1814539434437594 1.0 0.4550749692716506 2 Q15392 1 +FAD-binding, type PCMH-like superfamily [IPR036318] 0.8519515477792816 1.3362917150068694 0.1814539434437594 1.0 0.4550749692716506 2 Q15392 1 +Metalloenzyme, LuxS/M16 peptidase-like [IPR011249] 0.6048187738468211 1.325560743805443 0.1849852364676016 1.0 0.46148948466128 7 P22695,Q5JRX3,Q10713 3 +Metallopeptidase, catalytic domain superfamily [IPR024079] 0.6983164983165163 1.2551788056371191 0.209413857648248 1.0 0.4839207558465149 4 Q9BYT8,Q99797,P42892 3 +Beta-grasp domain superfamily [IPR012675] 0.5791856164822314 1.1946937810056926 0.2322066931349287 1.0 0.5063939556066218 7 Q9NTK5,P21912 2 +Chloride channel, core [IPR014743] 0.8176312247644686 1.1908655333989835 0.233706377113138 1.0 0.5063939556066218 2 P51798 1 +Amyloidogenic glycoprotein, heparin-binding domain superfamily [IPR036454] 0.7974427994616407 1.1059530069738566 0.2687468599125022 1.0 0.542068134461813 2 Q06481 1 +Pancreatic trypsin inhibitor Kunitz domain superfamily [IPR036880] 0.7974427994616407 1.1059530069738566 0.2687468599125022 1.0 0.542068134461813 2 Q06481 1 +Amyloidogenic glycoprotein, copper-binding domain superfamily [IPR036669] 0.7974427994616407 1.1059530069738566 0.2687468599125022 1.0 0.542068134461813 2 Q06481 1 +E2 domain superfamily [IPR036176] 0.7974427994616407 1.1059530069738566 0.2687468599125022 1.0 0.542068134461813 2 Q06481 1 +Prefoldin [IPR009053] 0.6099696867632188 1.1045691234640271 0.269346336318363 1.0 0.5421238361567052 5 Q9UHV9,P61758,O15212,Q9UBK9 4 +Aminopeptidase N-like , N-terminal domain superfamliy [IPR042097] 0.6048575482337888 1.0804491708006578 0.279942209790841 1.0 0.5483165596729697 5 Q9NZ08,Q9UIQ6 2 +Peptidase M4/M1, CTD superfamily [IPR027268] 0.6048575482337888 1.0804491708006578 0.279942209790841 1.0 0.5483165596729697 5 Q9NZ08,Q9UIQ6 2 +Immunoglobulin-like fold [IPR013783] 0.3811496752384033 1.0259222863791428 0.3049282167572769 1.0 0.5851658896475678 24 P35613,Q8IZA0,Q8NHP6,Q08722 4 +Arginyl tRNA synthetase N-terminal domain superfamily [IPR036695] 0.7627860026918003 0.9620162463087508 0.3360414431162457 1.0 0.6222017345199238 2 P54136 1 +Dimeric alpha-beta barrel [IPR011008] 0.7520188425302867 0.9179359620688776 0.3586523928776359 1.0 0.643944069030301 2 Q9BPW8 1 +Bcl-2-like superfamily [IPR036834] 0.7451861125756709 0.8884523624942043 0.3742974697145418 1.0 0.6644831484819955 3 Q9BXK5 1 +Inorganic polyphosphate/ATP-NAD kinase, N-terminal [IPR017438] 0.6096602370073592 0.8672071565044324 0.3858285158159846 1.0 0.6729115465980342 4 Q9NRA0,Q53H12 2 +NAD kinase/diacylglycerol kinase-like domain superfamily [IPR016064] 0.6096602370073592 0.8672071565044324 0.3858285158159846 1.0 0.6729115465980342 4 Q9NRA0,Q53H12 2 +Acyl transferase/acyl hydrolase/lysophospholipase [IPR016035] 0.7343884278103183 0.8469538204626393 0.3970208618164152 1.0 0.683480058685698 3 P49327 1 +Immunoglobulin E-set [IPR014756] 0.4177418638919118 0.8356127965091357 0.4033727674557394 1.0 0.6844620205698492 14 Q13432,A6NIH7 2 +HAD superfamily [IPR023214] 0.3635188486282213 0.8196094104720547 0.4124388072610516 1.0 0.6844620205698492 20 P20020,Q05D32,Q9UHY7,Q9HD20,P16615,P35670,Q969T7,Q3ZCQ8,P05023 9 +HAD-like superfamily [IPR036412] 0.3635188486282213 0.8196094104720547 0.4124388072610516 1.0 0.6844620205698492 20 P20020,Q05D32,Q9UHY7,Q9HD20,P16615,P35670,Q969T7,Q3ZCQ8,P05023 9 +Acyl transferase domain superfamily [IPR001227] 0.7217362045760531 0.7961582689716801 0.4259400496618835 1.0 0.6900311499372217 2 P49327 1 +Malonyl-CoA ACP transacylase, ACP-binding [IPR016036] 0.7217362045760531 0.7961582689716801 0.4259400496618835 1.0 0.6900311499372217 2 P49327 1 +Neurolysin/Thimet oligopeptidase, domain 2 [IPR024077] 0.6980814540558554 0.7102070621628236 0.477575742112627 1.0 0.7373067526639158 3 Q9BYT8,Q99797 2 +Neurolysin/Thimet oligopeptidase, N-terminal [IPR024080] 0.6978465679677002 0.7029784169089041 0.4820692000511577 1.0 0.7373067526639158 2 Q9BYT8 1 +Lamin tail domain superfamily [IPR036415] 0.6960619320094211 0.7027509758824798 0.4822109536365162 1.0 0.7373067526639158 3 P02545,P20700 2 +TGS-like [IPR012676] 0.4860293154209202 0.6867909716079672 0.4922144599609155 1.0 0.7383548937824176 6 Q9NTK5 1 +ANL, N-terminal domain [IPR042099] 0.5069046817110128 0.6274141130566464 0.5303878189903968 1.0 0.7495254280483066 5 Q6P1M0,O95573,Q4G176,P33121 4 +SCP2 sterol-binding domain superfamily [IPR036527] 0.6699448818296404 0.6080837771859164 0.5431319112069035 1.0 0.7495254280483066 3 Q6YN16 1 +Riboflavin synthase-like beta-barrel [IPR017938] 0.6455738808481818 0.5231892913676068 0.6008425327678621 1.0 0.7968566829356825 3 Q9UHQ9,P16435 2 +Ferredoxin-NADP reductase (FNR), nucleotide-binding domain [IPR039261] 0.6455738808481818 0.5231892913676068 0.6008425327678621 1.0 0.7968566829356825 3 Q9UHQ9,P16435 2 +BAG domain superfamily [IPR036533] 0.6443472409152127 0.5072748245289914 0.6119620004650217 1.0 0.8021934116475027 2 O95429 1 +Thiamin diphosphate-binding fold [IPR029061] 0.4417587981959229 0.4781109574911213 0.6325712335178146 1.0 0.8160663739570612 6 A1L0T0 1 +Ribosomal protein L37ae/L37e [IPR011331] 0.625841184387623 0.4449590853778323 0.6563493221270769 1.0 0.8229715019967316 2 P61513 1 +Zinc finger, Sec23/Sec24-type superfamily [IPR036174] 0.5050058328695975 0.4404135361055734 0.6596376228790977 1.0 0.8229715019967316 4 Q15437 1 +Sodium/potassium-transporting ATPase subunit beta superfamily [IPR038702] 0.6133916554508807 0.404919952101319 0.6855363518661604 1.0 0.8361303254736381 2 P54709 1 +Beta-hexosaminidase-like, domain 2 [IPR029018] 0.5653003144311346 0.2765248941793822 0.7821449419754678 1.0 0.8976675605239025 3 P54802 1 +Nucleotide-diphospho-sugar transferases [IPR029044] 0.3139617715828251 0.268790057031056 0.788091245203721 1.0 0.9021288978736378 17 Q8N4A0,Q16739 2 +Ferritin-like superfamily [IPR009078] 0.5518169582772645 0.233217851260226 0.8155922447051458 1.0 0.9242651311279232 2 P31350 1 +Cyclic nucleotide-binding-like [IPR018490] 0.4080184270577206 0.229323615027008 0.8186174003540181 1.0 0.9242651311279232 5 Q8IY17 1 +Threonyl/alanyl tRNA synthetase, class II-like, putative editing domain superfamily [IPR018163] 0.4078656665822101 0.2287983184766728 0.8190256737891661 1.0 0.9242651311279232 5 Q9BW92 1 +RmlC-like jelly roll fold [IPR014710] 0.3630992798650841 0.2280552084326914 0.8196033210308271 1.0 0.9242651311279232 9 Q8IY17,P38435 2 +Exocyst complex component EXOC6/Sec15, C-terminal, domain 1 [IPR042045] 0.5494616419919343 0.2276169176829696 0.8199440667495606 1.0 0.9242651311279232 2 Q9Y2D4 1 +MoaB/Mog-like domain superfamily [IPR036425] 0.5464333781965091 0.220527840106663 0.8254600927471742 1.0 0.9271755544127028 2 Q9NQX3 1 +FAD/NAD-linked reductase, dimerisation domain superfamily [IPR016156] 0.4308985308801939 0.1943025325159256 0.845939002764184 1.0 0.9421345369492112 4 O95831 1 +Rhodanese-like domain superfamily [IPR036873] 0.5304611242005939 0.19010504275016 0.8492268185984748 1.0 0.9427014332919836 3 Q99956,P25325 2 +Heat shock protein DnaJ, cysteine-rich domain superfamily [IPR036410] 0.5260854930999512 0.1802914832522764 0.8569237414977733 1.0 0.946810847249288 3 O60884,Q96EY1 2 +GTP-binding protein TrmE/Aminomethyltransferase GcvT, domain 1 [IPR027266] 0.5218707940780638 0.1677723032499096 0.8667624124225517 1.0 0.9532375486967274 2 Q8NCN5 1 +Sec1-like, domain 2 [IPR027482] 0.4188552188552196 0.1612639016404865 0.8718855534081753 1.0 0.9544428459941688 4 O00186,Q96AX1,Q8WVM8 3 +Sec1-like superfamily [IPR036045] 0.4188552188552196 0.1612639016404865 0.8718855534081753 1.0 0.9544428459941688 4 O00186,Q96AX1,Q8WVM8 3 +Sec1-like, domain 1 [IPR043154] 0.4188552188552196 0.1612639016404865 0.8718855534081753 1.0 0.9544428459941688 4 O00186,Q96AX1,Q8WVM8 3 +Sec1-like, domain 3a [IPR043127] 0.4188552188552196 0.1612639016404865 0.8718855534081753 1.0 0.9544428459941688 4 O00186,Q96AX1,Q8WVM8 3 +ESCRT assembly domain [IPR037202] 0.5107671601615076 0.1467365786564018 0.883339945502734 1.0 0.9658665148057576 2 Q99816 1 +Pyridoxal phosphate-dependent transferase, small domain [IPR015422] 0.3141631047122137 0.1415419447444008 0.8874418264484716 1.0 0.9681945174848032 12 O95470 1 +HSP20-like chaperone [IPR008978] 0.3429421331174511 0.1414535648044543 0.8875116410277362 1.0 0.9681945174848032 9 Q9P035 1 +AMP-binding enzyme, C-terminal domain superfamily [IPR045851] 0.5065634466509511 0.1394784583831307 0.8890720772610783 1.0 0.9687819876362096 3 Q6P1M0,Q4G176 2 +Nucleophile aminohydrolases, N-terminal [IPR029055] 0.2923339392572982 0.1334372461414381 0.8938475906127095 1.0 0.9728674120560832 17 P49721,P28070 2 +RuvBL1/2, DNA/RNA binding domain [IPR042487] 0.4962987886944955 0.1219628429528349 0.902928445557639 1.0 0.976145679260244 2 Q9Y230 1 +Profilin superfamily [IPR036140] 0.4929340511440145 0.1166259405537898 0.9071564804095728 1.0 0.976145679260244 2 P35080 1 +WW domain superfamily [IPR036020] 0.3694846749747374 0.1090524126241669 0.9131609189216436 1.0 0.9770615701328648 5 Q96J02,P46939,Q6ZWJ1,O75400 4 +Thiolase-like [IPR016039] 0.3470909172130682 0.1058104472471688 0.9157327476212728 1.0 0.9775264959186716 7 Q9BWD1 1 +Ribosomal protein S7 domain superfamily [IPR036823] 0.4791386271870929 0.0963914941038583 0.9232096473897082 1.0 0.9811689974500486 2 Q9Y2R9 1 +EB1, C-terminal domain superfamily [IPR036133] 0.4680349932705308 0.0819850881222955 0.9346585714876544 1.0 0.9903791177708556 2 Q15691 1 +Malic enzyme, N-terminal domain superfamily [IPR037062] 0.4576043068640729 0.0699220455081227 0.9442557062934394 1.0 0.9979424855810262 2 P48163 1 +Pyridoxal phosphate-dependent transferase, major domain [IPR015421] 0.29474117664543 0.0631972634349804 0.9496094238881372 1.0 0.999145098608162 13 O95470 1 +Pyridoxal phosphate-dependent transferase [IPR015424] 0.29474117664543 0.0631972634349804 0.9496094238881372 1.0 0.999145098608162 13 O95470 1 +Zinc-binding ribosomal protein [IPR011332] 0.4580949175361758 0.0595869709222253 0.9524845956272548 1.0 1.0 3 P61927,P61513 2 +Six-hairpin glycosidase superfamily [IPR008928] 0.438236284079427 0.0355092602798291 0.9716736623978166 1.0 1.0 3 P46020,Q13724 2 +Ribosomal protein S11 superfamily [IPR036967] 0.4131897711978493 0.0328770720390328 0.9737726167719912 1.0 1.0 2 P82912 1 +AH/BAR domain superfamily [IPR027267] 0.2850937959766819 0.0326696603006361 0.973938018543148 1.0 1.0 14 Q9Y371,O95219,Q9Y5X3 3 +Zinc finger, ZZ-type superfamily [IPR043145] 0.4071332436069987 0.0293958424822943 0.9765488885919072 1.0 1.0 2 Q13501 1 +PEBP-like superfamily [IPR036610] 0.4047779273216698 0.0281297358176395 0.9775586776998691 1.0 1.0 2 P30086 1 +MAN1, winged-helix domain [IPR041885] 0.3997308209959614 0.0255749385201855 0.9795963756940338 1.0 1.0 2 Q9Y2U8 1 +Mss4-like superfamily [IPR011057] 0.3953566621803608 0.0235284987317361 0.9812287060732796 1.0 1.0 2 Q7Z7K6 1 +Sec23/Sec24 helical domain superfamily [IPR036175] 0.3180634617448405 0.0189420547208772 0.9848873307349746 1.0 1.0 6 Q15437 1 +Gelsolin-like domain superfamily [IPR036180] 0.3180634617448405 0.0189420547208772 0.9848873307349746 1.0 1.0 6 Q15437 1 +PUA domain superfamily [IPR036974] 0.3684387617765859 0.0139320832310717 0.9888841654939696 1.0 1.0 2 Q9Y221 1 +Methylglyoxal synthase-like domain superfamily [IPR036914] 0.3660834454912477 0.0133057133808552 0.9893838899734456 1.0 1.0 2 P31939 1 +Class II aldolase/adducin N-terminal domain superfamily [IPR036409] 0.3384925975773863 0.0079177189397194 0.993682640307458 1.0 1.0 2 Q9UEY8 1 +Tetratricopeptide-like helical domain superfamily [IPR011990] 0.2481648497292646 0.0071992069146724 0.9942559135707744 1.0 1.0 84 Q6PGP7,Q9H7B4,Q6ZXV5,Q9NYH9,Q15006,Q9UPR3,O00411,Q13042,Q96DB5,O00231,Q32P28,P50542,P30260,Q96EK5,P49321,Q6DKK2,Q5R3I4,O76024,Q9UJX4,P54920,Q9Y3D6,O75153,Q9UJX3,O15091,Q92791,Q9UBV2,P13674,O75718,A0AVF1,Q9Y262,Q9Y6X3 31 +ATPase, F1/V1 complex, beta/alpha subunit, C-terminal [IPR024034] 0.2964333781964926 0.0043558544733371 0.9965245419568723 1.0 1.0 2 P06576 1 diff --git a/interpro_homologous_superfamily/selections.json b/interpro_homologous_superfamily/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..f270cae50e1c807158b81e284c9877ea963edb4c --- /dev/null +++ b/interpro_homologous_superfamily/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["14-3-3 domain superfamily [IPR036815]", "2Fe-2S ferredoxin-like superfamily [IPR036010]", "30s ribosomal protein S13, C-terminal [IPR027437]", "4'-phosphopantetheinyl transferase domain superfamily [IPR037143]", "5'-3' exonuclease, C-terminal domain superfamily [IPR036279]", "50S ribosomal protein L10, insertion domain superfamily [IPR043164]", "50S ribosomal protein L30e-like [IPR029064]", "6-phosphogluconate dehydrogenase, domain 2 [IPR013328]", "6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily [IPR008927]", "AAR2, C-terminal domain superfamily [IPR038514]", "AAR2, N-terminal domain superfamily [IPR038516]", "ABC transporter type 1, transmembrane domain superfamily [IPR036640]", "ACP-like superfamily [IPR036736]", "ADF-H/Gelsolin-like domain superfamily [IPR029006]", "ADP-ribosylation/Crystallin J1 superfamily [IPR036705]", "AF1104-like superfamily [IPR036075]", "AH/BAR domain superfamily [IPR027267]", "AICAR transformylase, duplicated domain superfamily [IPR024051]", "AICAR transformylase, insert domain superfamily [IPR024050]", "AMP-binding enzyme, C-terminal domain superfamily [IPR045851]", "ANL, N-terminal domain [IPR042099]", "ANTH domain superfamily [IPR014712]", "AP-2 complex subunit mu, C-terminal superfamily [IPR036168]", "ARFGAP/RecO-like zinc finger [IPR037278]", "ARID DNA-binding domain superfamily [IPR036431]", "ATP synthase subunit alpha, N-terminal domain-like superfamily [IPR023366]", "ATP synthase, F0 complex, subunit A superfamily [IPR035908]", "ATP synthase, F0 complex, subunit D superfamily, mitochondrial [IPR036228]", "ATP synthase, F1 complex, gamma subunit superfamily [IPR035968]", "ATP synthase, alpha subunit, C-terminal domain superfamily [IPR038376]", "ATP-NAD kinase, PpnK-type, C-terminal [IPR017437]", "ATP-grasp fold, subdomain 1 [IPR013815]", "ATP:guanido phosphotransferase, N-terminal domain superfamily [IPR036802]", "ATPase, F1/V1 complex, beta/alpha subunit, C-terminal [IPR024034]", "ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain superfamily [IPR036121]", "ATPase, V1 complex, subunit H, C-terminal domain superfamily [IPR038497]", "ATPase, nucleotide binding domain [IPR043129]", "Acetylglutamate kinase-like superfamily [IPR036393]", "Aconitase, domain 2 [IPR015932]", "Aconitase, iron-sulfur domain [IPR036008]", "Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 1/3 [IPR015931]", "Aconitase/3-isopropylmalate dehydratase, swivel [IPR015928]", "Actin-crosslinking [IPR008999]", "Actin-related protein 2/3 complex subunit 3 superfamily [IPR036753]", "Actin-related protein 2/3 complex subunit 5 superfamily [IPR036743]", "Activator of Hsp90 ATPase, Aha1 [IPR036338]", "Acyl transferase domain superfamily [IPR001227]", "Acyl transferase/acyl hydrolase/lysophospholipase [IPR016035]", "Acyl-CoA N-acyltransferase [IPR016181]", "Acyl-CoA binding protein superfamily [IPR035984]", "Acyl-CoA dehydrogenase-like, C-terminal [IPR036250]", "Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain superfamily [IPR009100]", "Acyl-CoA dehydrogenase/oxidase, N-terminal domain superfamily [IPR037069]", "Adenine nucleotide alpha hydrolase-like domains [IPR023382]", "Adenosylhomocysteinase-like superfamily [IPR042172]", "Adenylate cyclase-associated CAP, C-terminal superfamily [IPR036223]", "Adenylate cyclase-associated CAP, N-terminal domain superfamily [IPR036222]", "Adenylosuccinate synthetase, domain 1 [IPR042109]", "Adenylosuccinate synthetase, domain 2 [IPR042110]", "Adenylosuccinate synthetase, domain 3 [IPR042111]", "Alanine-tRNA ligase, class IIc, anti-codon-binding domain superfamily [IPR018162]", "Aldehyde dehydrogenase, C-terminal [IPR016163]", "Aldehyde dehydrogenase, N-terminal [IPR016162]", "Aldehyde/histidinol dehydrogenase [IPR016161]", "Aldolase-type TIM barrel [IPR013785]", "Alkaline-phosphatase-like, core domain superfamily [IPR017850]", "Allosteric substrate binding domain superfamily [IPR029009]", "Alpha-D-phosphohexomutase, C-terminal domain superfamily [IPR036900]", "Alpha-D-phosphohexomutase, alpha/beta/alpha I/II/III [IPR016055]", "Alpha-catenin/vinculin-like superfamily [IPR036723]", "Alpha-dystroglycan domain 2 [IPR027468]", "Alpha-glycerophosphate oxidase, C-terminal domain superfamily [IPR038299]", "Alpha-helical ferredoxin [IPR009051]", "Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain superfamily [IPR036784]", "Alpha-ketoglutarate-dependent dioxygenase AlkB-like superfamily [IPR037151]", "Alpha/Beta hydrolase fold [IPR029058]", "Alpha/beta knot methyltransferases [IPR029028]", "Amidase signature (AS) superfamily [IPR036928]", "Aminoacyl-tRNA synthetase, class I, anticodon-binding domain, subdomain 2 [IPR020751]", "Aminoacyl-tRNA synthetase, class I, anticodon-binding superfamily [IPR008925]", "Aminoacyl-tRNA synthetase, class Ia, anticodon-binding [IPR009080]", "Aminopeptidase N-like , N-terminal domain superfamliy [IPR042097]", "Amyloidogenic glycoprotein, amyloid-beta peptide superfamily [IPR037071]", "Amyloidogenic glycoprotein, copper-binding domain superfamily [IPR036669]", "Amyloidogenic glycoprotein, heparin-binding domain superfamily [IPR036454]", "Ankyrin repeat-containing domain superfamily [IPR036770]", "Annexin superfamily [IPR037104]", "Anticodon-binding domain superfamily [IPR036621]", "Antifreeze-like/N-acetylneuraminic acid synthase C-terminal domain superfamily [IPR036732]", "ApaG domain superfamily [IPR036767]", "ArfGAP domain superfamily [IPR038508]", "Arginyl tRNA synthetase N-terminal domain superfamily [IPR036695]", "Armadillo-like helical [IPR011989]", "Armadillo-type fold [IPR016024]", "Arp2/3 complex subunit 2/4 [IPR034666]", "Arrestin-like, C-terminal [IPR014752]", "Aspartate decarboxylase-like domain superfamily [IPR009010]", "Aspartate/ornithine carbamoyltransferase superfamily [IPR036901]", "Aspartic peptidase domain superfamily [IPR021109]", "At2g17340, three-helix bundle domain [IPR035073]", "B30.2/SPRY domain superfamily [IPR043136]", "BAG domain superfamily [IPR036533]", "BEACH domain superfamily [IPR036372]", "BRCT domain superfamily [IPR036420]", "BRK domain superfamily [IPR037259]", "BRO1 domain superfamily [IPR038499]", "BSD domain superfamily [IPR035925]", "Bacterial exopeptidase dimerisation domain [IPR036264]", "Band 7/SPFH domain superfamily [IPR036013]", "Barrier-to-autointegration factor, BAF superfamily [IPR036617]", "Bcl-2-like superfamily [IPR036834]", "Beta-catenin-interacting ICAT superfamily [IPR036911]", "Beta-grasp domain superfamily [IPR012675]", "Beta-hexosaminidase-like, domain 2 [IPR029018]", "Beta-lactamase/transpeptidase-like [IPR012338]", "BolA-like superfamily [IPR036065]", "Bromo adjacent homology (BAH) domain superfamily [IPR043151]", "Bromodomain-like superfamily [IPR036427]", "C-type lectin fold [IPR016187]", "C-type lectin-like/link domain superfamily [IPR016186]", "C2 domain superfamily [IPR035892]", "CAP Gly-rich domain superfamily [IPR036859]", "CCR4-NOT complex subunit 2/3/5, N-terminal domain superfamily [IPR038635]", "CCR4-NOT subunit 1, TTP binding domain superfamily [IPR038535]", "CDC48 domain 2-like superfamily [IPR029067]", "CDP-alcohol phosphatidyltransferase, transmembrane domain [IPR043130]", "CH domain superfamily [IPR036872]", "CRAL-TRIO lipid binding domain superfamily [IPR036865]", "CRAL/TRIO, N-terminal domain superfamily [IPR036273]", "CRIB domain superfamily [IPR036936]", "Cadherin-like superfamily [IPR015919]", "Calcyclin-binding protein, N-terminal [IPR037201]", "Calpain large subunit, domain III superfamily [IPR036213]", "Calreticulin/calnexin, P domain superfamily [IPR009033]", "Calycin [IPR012674]", "Carbamoyl-phosphate synthase small subunit, N-terminal domain superfamily [IPR036480]", "Carbamoyl-phosphate synthetase, large subunit oligomerisation domain superfamily [IPR036897]", "Carbohydrate-binding-like fold [IPR013784]", "Carboxypeptidase-like, regulatory domain superfamily [IPR008969]", "Carnitine o-acyltransferase, N-terminal [IPR042572]", "Casein kinase II subunit beta-like [IPR035991]", "Casein kinase II, regulatory subunit, N-terminal [IPR016149]", "Catenin binding domain superfamily [IPR027397]", "Cathepsin C, exclusion domain superfamily [IPR036496]", "Cation efflux transmembrane domain superfamily [IPR027469]", "Cdc37, Hsp90-binding domain superfamily [IPR038189]", "Cell division control protein 73, C-terminal domain superfamily [IPR038103]", "Chaperone J-domain superfamily [IPR036869]", "Chitinase insertion domain superfamily [IPR029070]", "Chloramphenicol acetyltransferase-like domain superfamily [IPR023213]", "Chloride channel, core [IPR014743]", "Choline/Carnitine o-acyltransferase, domain 2 [IPR042231]", "Chromo-like domain superfamily [IPR016197]", "Citrate synthase superfamily [IPR036969]", "Citrate synthase-like, large alpha subdomain [IPR016142]", "Citrate synthase-like, small alpha subdomain [IPR016143]", "Class I and II aminoacyl-tRNA synthetase, tRNA-binding arm [IPR010978]", "Class I glutamine amidotransferase-like [IPR029062]", "Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL) [IPR045864]", "Class II aldolase/adducin N-terminal domain superfamily [IPR036409]", "Clathrin adaptor, appendage, Ig-like subdomain superfamily [IPR013041]", "Clathrin adaptor, beta-adaptin, appendage, Ig-like subdomain [IPR013037]", "Clathrin heavy chain, N-terminal [IPR016025]", "ClpP/crotonase-like domain superfamily [IPR029045]", "Coatomer, gamma subunit, appendage domain superfamily [IPR037067]", "Coatomer/calthrin adaptor appendage, C-terminal subdomain [IPR009028]", "Cobalamin (vitamin B12)-dependent enzyme, catalytic [IPR016176]", "Cobalamin adenosyltransferase-like superfamily [IPR036451]", "Cobalamin-binding domain superfamily [IPR036724]", "Concanavalin A-like lectin/glucanase domain superfamily [IPR013320]", "Creatinase/Aminopeptidase P/Spt16, N-terminal [IPR029149]", "Creatinase/aminopeptidase-like [IPR036005]", "Cullin homology domain superfamily [IPR036317]", "Cullin repeat-like-containing domain superfamily [IPR016159]", "Cupredoxin [IPR008972]", "Cyclase-associated protein CAP/septum formation inhibitor MinC, C-terminal [IPR016098]", "Cyclic nucleotide-binding-like [IPR018490]", "Cyclic phosphodiesterase [IPR009097]", "Cyclin-like superfamily [IPR036915]", "Cyclophilin-like domain superfamily [IPR029000]", "Cytidine deaminase-like [IPR016193]", "Cytochrome C oxidase subunit II, transmembrane domain superfamily [IPR036257]", "Cytochrome P450 superfamily [IPR036396]", "Cytochrome b-c1 complex subunit 7 superfamily [IPR036544]", "Cytochrome b-c1 complex subunit 8 superfamily [IPR036642]", "Cytochrome b-c1 complex subunit 9 superfamily [IPR036656]", "Cytochrome b5-like heme/steroid binding domain superfamily [IPR036400]", "Cytochrome c oxidase subunit IV superfamily [IPR036639]", "Cytochrome c oxidase, subunit VIIa superfamily [IPR036539]", "Cytochrome c oxidase, subunit Va/VI superfamily [IPR036545]", "Cytochrome c oxidase, subunit Vb superfamily [IPR036972]", "Cytochrome c-like domain superfamily [IPR036909]", "Cytochrome c1, transmembrane anchor, C-terminal [IPR021157]", "Cytochrome cd1-nitrite reductase-like, haem d1 domain superfamily [IPR011048]", "DCN1-like, PONY binding domain [IPR042460]", "DHBP synthase RibB-like alpha/beta domain superfamily [IPR017945]", "DHS-like NAD/FAD-binding domain superfamily [IPR029035]", "DNA breaking-rejoining enzyme, catalytic core [IPR011010]", "DNA fragmentation factor 45kDa, C-terminal [IPR027296]", "DNA glycosylase [IPR011257]", "DNA ligase, ATP-dependent, N-terminal domain superfamily [IPR036599]", "DNA mismatch repair protein MutS, N-terminal [IPR016151]", "DNA mismatch repair protein MutS, core domain superfamily [IPR036187]", "DNA polymerase III, clamp loader complex, gamma/delta/delta subunit, C-terminal [IPR008921]", "DNA polymerase alpha, subunit B, N-terminal domain superfamily [IPR043034]", "DNA polymerase alpha, zinc finger domain superfamily [IPR038256]", "DNA polymerase delta subunit 3 superfamily [IPR041913]", "DNA polymerase family B, thumb domain [IPR042087]", "DNA polymerase, palm domain superfamily [IPR023211]", "DNA repair protein XRCC4-like, C-terminal [IPR014751]", "DNA topoisomerase I, DNA binding, N-terminal domain 1 [IPR013034]", "DNA topoisomerase I, DNA binding, N-terminal domain 2 [IPR013030]", "DNA topoisomerase I, DNA binding, eukaryotic-type, N-terminal domain superfamily [IPR036202]", "DNA topoisomerase I, catalytic core, alpha-helical subdomain, eukaryotic-type [IPR014711]", "DNA topoisomerase I, catalytic core, alpha/beta subdomain [IPR014727]", "DNA topoisomerase, type IIA, alpha-helical domain superfamily [IPR013757]", "DNA topoisomerase, type IIA, domain A, alpha-beta [IPR013758]", "DNA topoisomerase, type IIA, subunit B, C-terminal [IPR013759]", "DNA topoisomerase, type IIA-like domain superfamily [IPR013760]", "DNA-binding domain superfamily [IPR016177]", "DNA-directed RNA polymerase, N-terminal domain superfamily [IPR037159]", "DNA-directed RNA polymerase, insert domain superfamily [IPR036643]", "DNA-directed RNA polymerase, subunit 2, hybrid-binding domain superfamily [IPR037033]", "DNA/RNA non-specific endonuclease superfamily [IPR044929]", "DNA/RNA polymerase superfamily [IPR043502]", "DNA/RNA-binding protein KIN17, WH-like domain superfamily [IPR038254]", "DUSP-like superfamily [IPR035927]", "Daxx, N-terminal domain superfamily [IPR038298]", "Dbl homology (DH) domain superfamily [IPR035899]", "Death-like domain superfamily [IPR011029]", "Dedicator of cytokinesis, C-terminal, lobe A [IPR043161]", "Dedicator of cytokinesis, C-terminal, lobe C [IPR043162]", "Deoxyhypusine synthase superfamily [IPR036982]", "Diaphanous, GTPase-binding domain superfamily [IPR044933]", "Dihydrofolate reductase-like domain superfamily [IPR024072]", "Dihydropteroate synthase-like [IPR011005]", "Dimeric alpha-beta barrel [IPR011008]", "Diphthamide synthesis DPH1/DPH2, domain 1 [IPR042263]", "Diphthamide synthesis DPH1/DPH2, domain 3 [IPR042265]", "Dynein heavy chain AAA lid domain superfamily [IPR042219]", "Dynein heavy chain, AAA1 domain, small subdomain [IPR043157]", "Dynein heavy chain, C-terminal domain, barrel region [IPR043160]", "Dynein heavy chain, domain 2, N-terminal [IPR042222]", "Dynein heavy chain, linker, subdomain 3 [IPR042228]", "Dynein light chain superfamily [IPR037177]", "E2 domain superfamily [IPR036176]", "E3-binding domain superfamily [IPR036625]", "EB1, C-terminal domain superfamily [IPR036133]", "EF-G domain III/V-like [IPR035647]", "EF-hand domain pair [IPR011992]", "ENTH/VHS [IPR008942]", "ERO1-like superfamily [IPR037192]", "ERV/ALR sulfhydryl oxidase domain superfamily [IPR036774]", "ESCRT assembly domain [IPR037202]", "EXOC6/PINT-1/Sec15/Tip20, C-terminal, domain 2 [IPR042044]", "Elongation factor EF1B gamma, C-terminal domain superfamily [IPR036433]", "Elongation factor Ts, dimerisation domain superfamily [IPR036402]", "Endonuclease/exonuclease/phosphatase superfamily [IPR036691]", "Endoplasmic reticulum resident protein 29, C-terminal domain superfamily [IPR036356]", "Enhancer of mRNA-decapping protein 4, conserved C-terminal domain [IPR044938]", "Enhancer of rudimentary superfamily [IPR035912]", "Enolase-like, C-terminal domain superfamily [IPR036849]", "Enolase-like, N-terminal [IPR029017]", "Enoyl-CoA hydratase, C-terminal [IPR014748]", "Eukaryotic translation initiation factor 3-like domain superfamily [IPR023194]", "Exocyst complex component EXOC3/Sec6, C-terminal domain [IPR042532]", "Exocyst complex component EXOC6/Sec15, C-terminal, domain 1 [IPR042045]", "Exocyst component Exo84, C-terminal, subdomain 1 [IPR042561]", "Exocyst component Exo84, C-terminal, subdomain 2 [IPR042560]", "Exoribonuclease, PH domain 2 superfamily [IPR036345]", "F-actin capping protein, alpha subunit, domain 1 [IPR042489]", "F-actin-capping protein subunit alpha/beta [IPR037282]", "F-actin-capping protein subunit alpha/beta, domain 2 [IPR042276]", "F-actin-capping protein subunit beta, N-terminal domain [IPR043175]", "F-box-like domain superfamily [IPR036047]", "F1F0 ATP synthase OSCP/delta subunit, N-terminal domain superfamily [IPR026015]", "FAD-binding, type PCMH, subdomain 1 [IPR016167]", "FAD-binding, type PCMH, subdomain 2 [IPR016169]", "FAD-binding, type PCMH-like superfamily [IPR036318]", "FAD-linked oxidase-like, C-terminal [IPR016164]", "FAD/NAD(P)-binding domain superfamily [IPR036188]", "FAD/NAD-linked reductase, dimerisation domain superfamily [IPR016156]", "FCS-type zinc finger superfamily [IPR038603]", "FERM superfamily, second domain [IPR035963]", "FERM/acyl-CoA-binding protein superfamily [IPR014352]", "FF domain superfamily [IPR036517]", "FIP-RBD, C-terminal domain superfamily [IPR037245]", "FKBP12-rapamycin binding domain superfamily [IPR036738]", "FTO, C-terminal domain superfamily [IPR038413]", "Fe-S cluster assembly domain superfamily [IPR034904]", "Ferredoxin-NADP reductase (FNR), nucleotide-binding domain [IPR039261]", "Ferritin-like [IPR012347]", "Ferritin-like superfamily [IPR009078]", "Ferrodoxin-fold anticodon-binding domain superfamily [IPR036690]", "Fibronectin type II domain superfamily [IPR036943]", "Fibronectin type III superfamily [IPR036116]", "Flavoprotein-like superfamily [IPR029039]", "Formin, FH2 domain superfamily [IPR042201]", "Formyl transferase, N-terminal domain superfamily [IPR036477]", "Formyl transferase-like, C-terminal domain superfamily [IPR011034]", "Fumarase/histidase, N-terminal [IPR024083]", "Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain superfamily [IPR037099]", "Fumarylacetoacetase, N-terminal domain superfamily [IPR036462]", "Fumarylacetoacetase-like, C-terminal domain superfamily [IPR036663]", "G protein alpha subunit, helical insertion [IPR011025]", "G-protein gamma-like domain superfamily [IPR036284]", "GAD-like domain superfamily [IPR004115]", "GAR domain superfamily [IPR036534]", "GHMP kinase, C-terminal domain superfamily [IPR036554]", "GINS complex, subunit Psf3 superfamily [IPR038437]", "GINS, helical bundle-like domain superfamily [IPR036224]", "GM2-AP, lipid-recognition domain superfamily [IPR036846]", "GMP phosphodiesterase, delta subunit superfamily [IPR037036]", "GOLD domain superfamily [IPR036598]", "GSKIP domain superfamily [IPR023231]", "GTF2I-like repeat superfamily [IPR036647]", "GTP-binding protein TrmE/Aminomethyltransferase GcvT, domain 1 [IPR027266]", "GTP-binding protein, orthogonal bundle domain superfamily [IPR023179]", "GTP1/OBG domain superfamily [IPR036726]", "GYF-like domain superfamily [IPR035445]", "Galactose mutarotase-like domain superfamily [IPR011013]", "Galactose oxidase/kelch, beta-propeller [IPR011043]", "Galactose-binding-like domain superfamily [IPR008979]", "Gamma-glutamyl cyclotransferase-like superfamily [IPR036568]", "Gamma-tubulin complex component, C-terminal domain superfamily [IPR042241]", "Gelsolin-like domain superfamily [IPR036180]", "Glutamine synthetase/guanido kinase, catalytic domain [IPR014746]", "Glutaminyl-tRNA synthetase, class Ib, non-specific RNA-binding domain, N-terminal, subdomain 1 [IPR042558]", "Glutaminyl-tRNA synthetase, class Ib, non-specific RNA-binding domain, N-terminal, subdomain 2 [IPR042559]", "Glutathione S-transferase, C-terminal domain superfamily [IPR036282]", "Glutathione synthase, C-terminal, eukaryotic [IPR014709]", "Glutathione synthase, N-terminal, eukaryotic [IPR014049]", "Glutathione synthase, alpha-helical [IPR014042]", "Glutathione synthase, substrate-binding domain superfamily [IPR037013]", "Glycine cleavage T-protein/YgfZ, C-terminal [IPR029043]", "Glycoside hydrolase 38, N-terminal domain superfamily [IPR027291]", "Glycoside hydrolase families 57/38, central domain superfamily [IPR028995]", "Glycoside hydrolase family 38, central domain superfamily [IPR037094]", "Glycoside hydrolase superfamily [IPR017853]", "Glycoside hydrolase/deacetylase, beta/alpha-barrel [IPR011330]", "Glycosyl hydrolase family 63, N-terminal domain superfamily [IPR038518]", "Glycosyl hydrolase, all-beta [IPR013780]", "Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase [IPR029068]", "Golgi phosphoprotein 3-like domain superfamily [IPR038261]", "GroEL-like apical domain superfamily [IPR027409]", "GroEL-like equatorial domain superfamily [IPR027413]", "GroES chaperonin superfamily [IPR037124]", "GroES-like superfamily [IPR011032]", "Growth arrest and DNA damage-inducible proteins-interacting protein 1 domain superfamily [IPR043035]", "Growth factor receptor cysteine-rich domain superfamily [IPR009030]", "GrpE nucleotide exchange factor, coiled-coil [IPR013805]", "GrpE nucleotide exchange factor, head [IPR009012]", "Guanylate-binding protein, C-terminal domain superfamily [IPR036543]", "H/ACA RNP complex subunit Gar1/Naf1, Cbf5-binding domain [IPR038664]", "HAD superfamily [IPR023214]", "HAD-like superfamily [IPR036412]", "HBS1-like protein, N-terminal domain superfamily [IPR037189]", "HECT, E3 ligase catalytic domain [IPR035983]", "HIT-like superfamily [IPR036265]", "HIV integrase-binding domain superfamily [IPR036218]", "HORMA domain superfamily [IPR036570]", "HR1 repeat superfamily [IPR036274]", "HRDC domain superfamily [IPR044876]", "HRDC-like superfamily [IPR010997]", "HSP20-like chaperone [IPR008978]", "HSP40/DnaJ peptide-binding [IPR008971]", "HSP90, C-terminal domain [IPR037196]", "Haem oxygenase-like, multi-helical [IPR016084]", "Heat shock protein 70kD, C-terminal domain superfamily [IPR029048]", "Heat shock protein 70kD, peptide-binding domain superfamily [IPR029047]", "Heat shock protein DnaJ, cysteine-rich domain superfamily [IPR036410]", "Heavy metal-associated domain superfamily [IPR036163]", "Helix hairpin bin domain superfamily [IPR029012]", "Helix-hairpin-helix, base-excision DNA repair, C-terminal [IPR023170]", "Hemimethylated DNA-binding domain superfamily [IPR036623]", "High mobility group box domain superfamily [IPR036910]", "His-Me finger superfamily [IPR044925]", "Histidine kinase/HSP90-like ATPase superfamily [IPR036890]", "Histidine phosphatase superfamily [IPR029033]", "Histone acetyl transferase 1, N-terminal domain superfamily [IPR037113]", "Histone acetyltransferase HAT1, C-terminal [IPR013523]", "Histone deacetylase domain superfamily [IPR037138]", "Histone-fold [IPR009072]", "Homeobox-like domain superfamily [IPR009057]", "Homocysteine-binding domain superfamily [IPR036589]", "HotDog domain superfamily [IPR029069]", "Hydroxymethylglutaryl-CoA reductase, N-terminal [IPR023282]", "Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain superfamily [IPR009023]", "Hydroxymethylglutaryl-CoA reductase, class I/II, catalytic domain superfamily [IPR023074]", "Hydroxymethylglutaryl-CoA reductase, class I/II, substrate-binding domain superfamily [IPR009029]", "I/LWEQ domain superfamily [IPR035964]", "ISWI, HAND domain superfamily [IPR036306]", "Immunoglobulin E-set [IPR014756]", "Immunoglobulin-like domain superfamily [IPR036179]", "Immunoglobulin-like fold [IPR013783]", "Importin-alpha, importin-beta-binding domain superfamily [IPR036975]", "Initiation factor 2B-like, C-terminal [IPR042529]", "Inorganic polyphosphate/ATP-NAD kinase, N-terminal [IPR017438]", "Inorganic pyrophosphatase superfamily [IPR036649]", "Inosine triphosphate pyrophosphatase-like [IPR029001]", "Integrin beta tail domain superfamily [IPR036349]", "Integrin domain superfamily [IPR032695]", "Invasin/intimin cell-adhesion fragments [IPR008964]", "Isochorismatase-like superfamily [IPR036380]", "Isopenicillin N synthase-like superfamily [IPR027443]", "Isoprenoid synthase domain superfamily [IPR008949]", "K Homology domain, type 1 superfamily [IPR036612]", "K homology domain superfamily, prokaryotic type [IPR009019]", "K homology domain-like, alpha/beta [IPR015946]", "KA1 domain/Ssp2, C-terminal [IPR028375]", "Kelch-type beta propeller [IPR015915]", "Kinesin motor domain superfamily [IPR036961]", "Kinesin-like protein Kif23, Arf6-interacting domain superfamily [IPR038105]", "Kringle-like fold [IPR013806]", "Ku, C-terminal domain superfamily [IPR036494]", "Ku70, bridge and pillars domain superfamily [IPR027388]", "L-Aspartase-like [IPR008948]", "L1 transposable element, C-terminal domain [IPR042566]", "L21-like superfamily [IPR036164]", "L27 domain superfamily [IPR036892]", "L28p-like [IPR034704]", "LAP1C-like, C-terminal domain superfamily [IPR038599]", "LDL receptor-like superfamily [IPR036055]", "LEM/LEM-like domain superfamily [IPR011015]", "LIS1, N-terminal [IPR037190]", "LSM domain superfamily [IPR010920]", "Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal [IPR015955]", "Lambda repressor-like, DNA-binding domain superfamily [IPR010982]", "Lamin tail domain superfamily [IPR036415]", "LepA, C-terminal domain superfamily [IPR038363]", "Leucine-rich repeat domain superfamily [IPR032675]", "LexA/Signal peptidase-like superfamily [IPR036286]", "Longin-like domain superfamily [IPR011012]", "LysM domain superfamily [IPR036779]", "MAGE homology domain, winged helix WH1 motif [IPR041898]", "MAGE homology domain, winged helix WH2 motif [IPR041899]", "MAN1, winged-helix domain [IPR041885]", "MFS transporter superfamily [IPR036259]", "MHC class I-like antigen recognition-like superfamily [IPR037055]", "MHC classes I/II-like antigen recognition protein [IPR011162]", "MIT domain superfamily [IPR036181]", "MOB kinase activator superfamily [IPR036703]", "MRG, C-terminal domain superfamily [IPR038217]", "MTH938-like superfamily [IPR036748]", "Macro domain-like [IPR043472]", "Malic enzyme, N-terminal domain superfamily [IPR037062]", "Malonyl-CoA ACP transacylase, ACP-binding [IPR016036]", "Manganese/iron superoxide dismutase, C-terminal domain superfamily [IPR036314]", "Manganese/iron superoxide dismutase, N-terminal domain superfamily [IPR036324]", "Mannose-6-phosphate receptor binding domain superfamily [IPR009011]", "Mediator complex subunit 25, PTOV domain superfamily [IPR038196]", "Mediator complex, subunit Med7/Med21-like [IPR037212]", "Membrane associated eicosanoid/glutathione metabolism-like domain superfamily [IPR023352]", "Metal-dependent hydrolase [IPR032466]", "Metal-dependent hydrolase, composite domain superfamily [IPR011059]", "Metallo-dependent phosphatase-like [IPR029052]", "Metalloenzyme, LuxS/M16 peptidase-like [IPR011249]", "Metallopeptidase, catalytic domain superfamily [IPR024079]", "Methionine synthase domain [IPR036594]", "Methionyl-tRNA synthetase, Zn-domain [IPR029038]", "Methylglyoxal synthase-like domain superfamily [IPR036914]", "Methylpurine-DNA glycosylase superfamily [IPR036995]", "Methylthiotransferase, N-terminal domain superfamily [IPR038135]", "Mib/herc2 domain superfamily [IPR037252]", "MitoNEET, CDGSH iron-sulfur domain [IPR042216]", "Mitochondrial carrier domain superfamily [IPR023395]", "Mitochondrial cytochrome c oxidase subunit VIc/VIIs superfamily [IPR037169]", "Mitochondrial glycoprotein superfamily [IPR036561]", "Mitochondrial outer membrane translocase complex, Tom20 domain superfamily [IPR023392]", "Mitochondrial ribosomal protein L55 superfamily [IPR044884]", "MoaB/Mog-like domain superfamily [IPR036425]", "MoeA, C-terminal, domain IV superfamily [IPR036688]", "MoeA, N-terminal and linker domain superfamily [IPR036135]", "Moesin tail domain superfamily [IPR008954]", "Mre11, capping domain [IPR038487]", "Mss4-like superfamily [IPR011057]", "Mss4/translationally controlled tumour-associated TCTP [IPR011323]", "Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal domain superfamily [IPR042179]", "MutS, connector domain superfamily [IPR036678]", "Myosin S1 fragment, N-terminal [IPR008989]", "NAC A/B domain superfamily [IPR038187]", "NAD kinase/diacylglycerol kinase-like domain superfamily [IPR016064]", "NAD(P)-binding domain superfamily [IPR036291]", "NADH-quinone oxidoreductase subunit E, N-terminal [IPR041921]", "NADH-ubiquinone oxidoreductase 51kDa subunit, FMN-binding domain superfamily [IPR037225]", "NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain superfamily [IPR037207]", "NADH:ubiquinone oxidoreductase, 30kDa subunit superfamily [IPR037232]", "NADP-dependent oxidoreductase domain superfamily [IPR036812]", "NADPH-cytochrome p450 reductase, FAD-binding, alpha-helical domain superfamily [IPR023173]", "NAP-like superfamily [IPR037231]", "NET domain superfamily [IPR038336]", "NO signalling/Golgi transport ligand-binding domain superfamily [IPR024096]", "NOB1 zinc finger-like superfamily [IPR036283]", "NTF2-like domain superfamily [IPR032710]", "NUDIX hydrolase-like domain superfamily [IPR015797]", "NVL2, N-terminal domain superfamily [IPR038100]", "NagB/RpiA transferase-like [IPR037171]", "Neurolysin/Thimet oligopeptidase, N-terminal [IPR024080]", "Neurolysin/Thimet oligopeptidase, domain 2 [IPR024077]", "Nicotinate phosphoribosyltransferase-like, C-terminal [IPR036068]", "Nitrogen regulatory PII-like, alpha/beta [IPR011322]", "Nitrogen regulatory protein PII/ATP phosphoribosyltransferase, C-terminal [IPR015867]", "Nitrous oxide reductase, N-terminal [IPR011045]", "Nop domain superfamily [IPR036070]", "Nop, C-terminal domain [IPR042239]", "Nucleic acid-binding, OB-fold [IPR012340]", "Nucleophile aminohydrolases, N-terminal [IPR029055]", "Nucleoplasmin core domain superfamily [IPR036824]", "Nucleoporin, Nup155-like, C-terminal, subdomain 1 [IPR042533]", "Nucleoporin, Nup155-like, C-terminal, subdomain 2 [IPR042537]", "Nucleoporin, Nup155-like, C-terminal, subdomain 3 [IPR042538]", "Nucleoside diphosphate kinase-like domain superfamily [IPR036850]", "Nucleoside phosphorylase superfamily [IPR035994]", "Nucleotide-binding alpha-beta plait domain superfamily [IPR012677]", "Nucleotide-diphospho-sugar transferases [IPR029044]", "Nucleotidyltransferase superfamily [IPR043519]", "Nucleotidyltransferase, class I-like, C-terminal [IPR011068]", "Nuf2, N-terminal domain superfamily [IPR038275]", "NusG, N-terminal domain superfamily [IPR036735]", "Oxygen-dependent coproporphyrinogen III oxidase superfamily [IPR036406]", "Oxysterol-binding protein superfamily [IPR037239]", "P-loop containing nucleoside triphosphate hydrolase [IPR027417]", "P-type ATPase, A domain superfamily [IPR008250]", "P-type ATPase, cytoplasmic domain N [IPR023299]", "P-type ATPase, transmembrane domain superfamily [IPR023298]", "P-type trefoil domain superfamily [IPR044913]", "PABC (PABP) domain [IPR036053]", "PADR1 domain superfamily [IPR038650]", "PBDC1-like domain superfamily [IPR023139]", "PD-(D/E)XK endonuclease-like domain superfamily [IPR011604]", "PDCD5-like superfamily [IPR036883]", "PDZ superfamily [IPR036034]", "PEBP-like superfamily [IPR036610]", "PFU domain superfamily [IPR038122]", "PH-like domain superfamily [IPR011993]", "PIN-like domain superfamily [IPR029060]", "PITH domain superfamily [IPR037047]", "PKD domain superfamily [IPR035986]", "PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily [IPR017946]", "PLP-binding barrel [IPR029066]", "PNPase/RNase PH domain superfamily [IPR027408]", "POLO box domain superfamily [IPR036947]", "PPM-type phosphatase domain superfamily [IPR036457]", "PRP4-like superfamily [IPR036285]", "PTPA superfamily [IPR037218]", "PUA domain superfamily [IPR036974]", "PUA-like superfamily [IPR015947]", "PWI domain superfamily [IPR036483]", "PX domain superfamily [IPR036871]", "Paired amphipathic helix superfamily [IPR036600]", "Pancreatic trypsin inhibitor Kunitz domain superfamily [IPR036880]", "PapD-like superfamily [IPR008962]", "Papain-like cysteine peptidase superfamily [IPR038765]", "Pelota/DOM34, N-terminal domain [IPR038069]", "Peptidase C12, ubiquitin carboxyl-terminal hydrolase superfamily [IPR036959]", "Peptidase C65, otubain, subdomain 2 [IPR042467]", "Peptidase C65, otubain, subdomain 1 [IPR042468]", "Peptidase M1, LTA-4 hydrolase/aminopeptidase, C-terminal domain superfamily [IPR038502]", "Peptidase M13, domain 2 [IPR042089]", "Peptidase M4/M1, CTD superfamily [IPR027268]", "Peptidase M41-like [IPR037219]", "Peptidase M60, enhancin-like domain 3 [IPR042279]", "Peptidase S1, PA clan [IPR009003]", "Peptidase S59, nucleoporin superfamily [IPR036903]", "Peptidase S8/S53 domain superfamily [IPR036852]", "Peptidyl-tRNA hydrolase II domain superfamily [IPR023476]", "Pex19, C-terminal domain superfamily [IPR038322]", "Phenylalanyl-tRNA synthetase-like, B3/B4 [IPR020825]", "Phosphatidic acid phosphatase type 2/haloperoxidase superfamily [IPR036938]", "Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily [IPR036940]", "Phosphatidylinositol-4-phosphate 5-kinase, N-terminal [IPR027484]", "Phosphoenolpyruvate carboxykinase, C-terminal [IPR013035]", "Phosphoenolpyruvate carboxykinase, N-terminal [IPR008210]", "Phosphofructokinase superfamily [IPR035966]", "Phosphoglucose isomerase, C-terminal [IPR023096]", "Phosphoglycerate kinase superfamily [IPR036043]", "Phosphoglycerate kinase, N-terminal [IPR015824]", "Phosphoglycolate phosphatase-like, domain 2 [IPR023198]", "Phospholipase B-like, domain 1 [IPR043040]", "Phospholipase B-like, domain 2 [IPR043041]", "Phospholipase B-like, domain 3 [IPR043042]", "Phosphoribosylformylglycinamidine synthase subunit PurS-like superfamily [IPR036604]", "Phosphoribosylglycinamide synthetase, C-domain superfamily [IPR037123]", "Phosphoribosyltransferase-like [IPR029057]", "Phosphorylated adapter RNA export protein, RNA-binding domain superfamily [IPR038092]", "Phosphotransferase/anion transporter [IPR016152]", "Phosphotyrosine protein phosphatase I superfamily [IPR036196]", "Phosphotyrosyl phosphatase activator, C-terminal lid domain [IPR043170]", "Plakin repeat superfamily [IPR035915]", "Poly(ADP-ribose) polymerase, regulatory domain superfamily [IPR036616]", "Polyketide synthase, dehydratase domain superfamily [IPR042104]", "Polymerase/histidinol phosphatase-like [IPR016195]", "Polyribonucleotide nucleotidyltransferase, RNA-binding domain superfamily [IPR036456]", "Porin domain superfamily [IPR023614]", "Porphobilinogen deaminase, C-terminal domain superfamily [IPR036803]", "Pre-ATP-grasp domain superfamily [IPR016185]", "Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding domain superfamily [IPR042516]", "Prefoldin [IPR009053]", "Profilin superfamily [IPR036140]", "Prolyl-tRNA synthetase, class II [IPR017449]", "Proteasomal ubiquitin receptor Rpn13/ADRM1, Pru domain superfamily [IPR038633]", "Proteasome activator PA28, C-terminal domain superfamily [IPR036997]", "Proteasome activator PA28, N-terminal domain superfamily [IPR036996]", "Proteasome activator superfamily [IPR036252]", "Protein arginine methyltransferase NDUFAF7 superfamily [IPR038375]", "Protein kinase-like domain superfamily [IPR011009]", "Protein translocase SecE domain superfamily [IPR023391]", "Protein-tyrosine phosphatase-like [IPR029021]", "Prp8 RNase domain IV, fingers region [IPR043173]", "Prp8 RNase domain IV, palm region [IPR043172]", "Pseudouridine synthase, TruD, catalytic domain [IPR042214]", "Pseudouridine synthase, catalytic domain superfamily [IPR020103]", "Pterin 4 alpha carbinolamine dehydratase superfamily [IPR036428]", "PurM-like, C-terminal domain superfamily [IPR036676]", "PurM-like, N-terminal domain superfamily [IPR036921]", "Putative DNA-binding domain superfamily [IPR009061]", "Pyridoxal phosphate-dependent transferase [IPR015424]", "Pyridoxal phosphate-dependent transferase, major domain [IPR015421]", "Pyridoxal phosphate-dependent transferase, small domain [IPR015422]", "Pyruvate kinase, C-terminal domain superfamily [IPR036918]", "Pyruvate kinase, insert domain superfamily [IPR015806]", "Pyruvate kinase-like domain superfamily [IPR040442]", "Pyruvate kinase-like, insert domain superfamily [IPR011037]", "Pyruvate/Phosphoenolpyruvate kinase-like domain superfamily [IPR015813]", "Queuine tRNA-ribosyltransferase-like [IPR036511]", "Quinoprotein alcohol dehydrogenase-like superfamily [IPR011047]", "Quinoprotein amine dehydrogenase, beta chain-like [IPR011044]", "R3H domain superfamily [IPR036867]", "RAP domain superfamily [IPR036744]", "RGS domain superfamily [IPR036305]", "RGS, subdomain 2 [IPR044926]", "RNA 3'-terminal phosphate cyclase domain superfamily [IPR037136]", "RNA 3'-terminal phosphate cyclase, insert domain superfamily [IPR036553]", "RNA 3'-terminal phosphate cyclase/enolpyruvate transferase, alpha/beta [IPR013792]", "RNA polymerase Rpb1, clamp domain superfamily [IPR044893]", "RNA polymerase Rpb1, domain 3 superfamily [IPR042102]", "RNA polymerase Rpb1, domain 7 superfamily [IPR038593]", "RNA polymerase Rpb1, funnel domain superfamily [IPR038120]", "RNA polymerase Rpb2, OB-fold [IPR014724]", "RNA polymerase Rpb2, domain 2 superfamily [IPR037034]", "RNA polymerase Rpb5, N-terminal domain superfamily [IPR036710]", "RNA polymerase Rpb7-like, N-terminal domain superfamily [IPR036898]", "RNA polymerase subunit RPB10 [IPR023580]", "RNA polymerase, RBP11-like subunit [IPR036603]", "RNA-binding S4 domain superfamily [IPR036986]", "RNA-binding domain superfamily [IPR035979]", "RPB5-like RNA polymerase subunit superfamily [IPR035913]", "RPB6/omega subunit-like superfamily [IPR036161]", "RPN13, DEUBAD domain superfamily [IPR038108]", "RRF superfamily [IPR036191]", "RUN domain superfamily [IPR037213]", "Rab-GTPase-TBC domain superfamily [IPR035969]", "Radical SAM, alpha/beta horseshoe [IPR023404]", "Ran-GTPase activating protein 1, C-terminal domain superfamily [IPR036720]", "Ras guanine nucleotide exchange factor domain superfamily [IPR023578]", "Ras guanine-nucleotide exchange factor, catalytic domain superfamily [IPR036964]", "Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II [IPR009091]", "Regulatory factor, effector binding domain superfamily [IPR011256]", "Restriction endonuclease type II-like [IPR011335]", "Rho GDP-dissociation inhibitor domain superfamily [IPR024792]", "Rho GTPase activation protein [IPR008936]", "Rhodanese-like domain superfamily [IPR036873]", "Rhomboid-like superfamily [IPR035952]", "Riboflavin synthase-like beta-barrel [IPR017938]", "Ribokinase-like [IPR029056]", "Ribonuclease H superfamily [IPR036397]", "Ribonuclease H-like superfamily [IPR012337]", "Ribonuclease H1, N-terminal domain superfamily [IPR037056]", "Ribonuclease HII, helix-loop-helix cap domain superfamily [IPR023160]", "Ribonuclease III, endonuclease domain superfamily [IPR036389]", "Ribonuclease T2-like superfamily [IPR036430]", "Ribonuclease Z/Hydroxyacylglutathione hydrolase-like [IPR036866]", "Ribonucleotide reductase R1 subunit, N-terminal [IPR008926]", "Ribonucleotide reductase-like [IPR012348]", "Ribosomal L15/L27a, N-terminal [IPR027386]", "Ribosomal L18e/L15P superfamily [IPR036227]", "Ribosomal RNA-processing protein 8, N-terminal domain [IPR042036]", "Ribosomal protein L1, 3-layer alpha/beta-sandwich [IPR016095]", "Ribosomal protein L1-like [IPR023674]", "Ribosomal protein L10-like domain superfamily [IPR043141]", "Ribosomal protein L10e/L16 superfamily [IPR036920]", "Ribosomal protein L11, C-terminal domain superfamily [IPR036769]", "Ribosomal protein L11/L12, N-terminal domain superfamily [IPR036796]", "Ribosomal protein L13 superfamily [IPR036899]", "Ribosomal protein L14 superfamily [IPR036853]", "Ribosomal protein L15e core domain superfamily [IPR024794]", "Ribosomal protein L17 superfamily [IPR036373]", "Ribosomal protein L19 superfamily [IPR038657]", "Ribosomal protein L19/L19e superfamily [IPR035970]", "Ribosomal protein L19/L19e, domain 1 [IPR015972]", "Ribosomal protein L2, domain 2 [IPR014722]", "Ribosomal protein L2, domain 3 [IPR014726]", "Ribosomal protein L21 superfamily [IPR036948]", "Ribosomal protein L22/L17 superfamily [IPR036394]", "Ribosomal protein L22e superfamily [IPR038526]", "Ribosomal protein L23/L15e core domain superfamily [IPR012678]", "Ribosomal protein L24e/L24 superfamily [IPR038630]", "Ribosomal protein L25/Gln-tRNA synthetase, N-terminal [IPR020056]", "Ribosomal protein L25/Gln-tRNA synthetase, anti-codon-binding domain superfamily [IPR011035]", "Ribosomal protein L27e superfamily [IPR038655]", "Ribosomal protein L28/L24 superfamily [IPR037147]", "Ribosomal protein L29/L35 superfamily [IPR036049]", "Ribosomal protein L3, domain 3, archaeal type superfamily [IPR044892]", "Ribosomal protein L30, ferredoxin-like fold domain superfamily [IPR036919]", "Ribosomal protein L31e domain superfamily [IPR023621]", "Ribosomal protein L32e superfamily [IPR036351]", "Ribosomal protein L35A superfamily [IPR038661]", "Ribosomal protein L36e domain superfamily [IPR038097]", "Ribosomal protein L37ae/L37e [IPR011331]", "Ribosomal protein L38e superfamily [IPR038464]", "Ribosomal protein L4 domain superfamily [IPR023574]", "Ribosomal protein L5 domain superfamily [IPR022803]", "Ribosomal protein L6, alpha-beta domain superfamily [IPR036789]", "Ribosomal protein L7/L12, C-terminal/adaptor protein ClpS-like [IPR014719]", "Ribosomal protein L7/L12, oligomerisation domain superfamily [IPR036235]", "Ribosomal protein L9, N-terminal domain superfamily [IPR036935]", "Ribosomal protein L9/RNase H1, N-terminal [IPR009027]", "Ribosomal protein P1/P2, N-terminal domain [IPR038716]", "Ribosomal protein S10 domain superfamily [IPR036838]", "Ribosomal protein S11 superfamily [IPR036967]", "Ribosomal protein S13-like, H2TH [IPR010979]", "Ribosomal protein S14/S29 [IPR043140]", "Ribosomal protein S16 domain superfamily [IPR023803]", "Ribosomal protein S17e-like superfamily [IPR036401]", "Ribosomal protein S18 superfamily [IPR036870]", "Ribosomal protein S2, flavodoxin-like domain superfamily [IPR023591]", "Ribosomal protein S21e superfamily [IPR038579]", "Ribosomal protein S3, C-terminal domain superfamily [IPR036419]", "Ribosomal protein S4e, central domain superfamily [IPR038237]", "Ribosomal protein S5 domain 2-type fold [IPR020568]", "Ribosomal protein S5 domain 2-type fold, subgroup [IPR014721]", "Ribosomal protein S7 domain superfamily [IPR036823]", "Ribosomal protein S8 superfamily [IPR035987]", "Ribosomal protein S8e subdomain, eukaryotes [IPR042563]", "Ribosome maturation protein SBDS, N-terminal domain superfamily [IPR036786]", "Ribosome maturation protein Sdo1/SBDS, central domain superfamily [IPR037188]", "Ribosome-associated complex head domain superfamily [IPR042569]", "Ribulose-phosphate binding barrel [IPR011060]", "Ricin B-like lectins [IPR035992]", "RmlC-like cupin domain superfamily [IPR011051]", "RmlC-like jelly roll fold [IPR014710]", "Rossmann-like alpha/beta/alpha sandwich fold [IPR014729]", "Rpb4/RPC9 superfamily [IPR038324]", "Rudiment single hybrid motif [IPR011054]", "RutC-like superfamily [IPR035959]", "RuvA domain 2-like [IPR010994]", "RuvBL1/2, DNA/RNA binding domain [IPR042487]", "S-adenosyl-L-methionine-dependent methyltransferase [IPR029063]", "S-adenosylmethionine synthetase superfamily [IPR022636]", "S15/NS1, RNA-binding [IPR009068]", "SAP domain superfamily [IPR036361]", "SCP2 sterol-binding domain superfamily [IPR036527]", "SGNH hydrolase superfamily [IPR036514]", "SH2 domain superfamily [IPR036860]", "SH3-like domain superfamily [IPR036028]", "SKP1-like, dimerisation domain superfamily [IPR036296]", "SKP1/BTB/POZ domain superfamily [IPR011333]", "SLED domain superfamily [IPR038348]", "SMAD/FHA domain superfamily [IPR008984]", "SMCs flexible hinge superfamily [IPR036277]", "SNARE [IPR010989]", "SNF2-like, N-terminal domain superfamily [IPR038718]", "SNase-like, OB-fold superfamily [IPR035437]", "SOS response associated peptidase-like [IPR036590]", "SPOC-like, C-terminal domain superfamily [IPR016194]", "SRA-YDG superfamily [IPR036987]", "SRCR-like domain superfamily [IPR036772]", "SRP/SRP receptor, N-terminal [IPR036225]", "SRP68, N-terminal domain superfamily [IPR038253]", "SSRP1 domain superfamily [IPR038167]", "START-like domain superfamily [IPR023393]", "STAT transcription factor, DNA-binding, N-terminal [IPR012345]", "STAT transcription factor, N-terminal domain superfamily [IPR036535]", "STAT transcription factor, coiled coil [IPR015988]", "STAT1, C-terminal domain superfamily [IPR038295]", "SUI1 domain superfamily [IPR036877]", "SWAP/Surp superfamily [IPR035967]", "SWIB/MDM2 domain superfamily [IPR036885]", "Saposin-like [IPR011001]", "Scaffold protein Nfu/NifU, N-terminal domain superfamily [IPR036498]", "Scavenger mRNA decapping enzyme, N-terminal [IPR011145]", "Schlafen, AlbA_2 domain superfamily [IPR038461]", "ScpA-like, C-terminal [IPR023093]", "Sec1-like superfamily [IPR036045]", "Sec1-like, domain 1 [IPR043154]", "Sec1-like, domain 2 [IPR027482]", "Sec1-like, domain 3a [IPR043127]", "Sec23/Sec24 helical domain superfamily [IPR036175]", "Sec7 domain superfamily [IPR035999]", "Sec7, C-terminal domain superfamily [IPR023394]", "SecY domain superfamily [IPR023201]", "Serine carboxypeptidase S28, SKS domain [IPR042269]", "Serine-tRNA synthetase, type1, N-terminal domain superfamily [IPR042103]", "Serpin superfamily [IPR036186]", "Serpin superfamily, domain 1 [IPR042178]", "Serpin superfamily, domain 2 [IPR042185]", "Seven-hairpin glycosidases [IPR036026]", "Signal recognition particle SRP54, N-terminal domain superfamily [IPR042101]", "Signal recognition particle, SRP54 subunit, M-domain superfamily [IPR036891]", "Signal recognition particle, SRP9/SRP14 subunit [IPR009018]", "Sin3 associated polypeptide p18 superfamily [IPR042534]", "Single hybrid motif [IPR011053]", "Sirtuin, catalytic core small domain superfamily [IPR026591]", "Six-bladed beta-propeller, TolB-like [IPR011042]", "Six-hairpin glycosidase superfamily [IPR008928]", "Six-hairpin glycosidase-like superfamily [IPR012341]", "Smac/DIABLO-like superfamily [IPR009062]", "Smaug, PHAT domain superfamily [IPR037093]", "Sodium/potassium-transporting ATPase subunit beta superfamily [IPR038702]", "Sodium:dicarboxylate symporter superfamily [IPR036458]", "Sodium:neurotransmitter symporter superfamily [IPR037272]", "Spermadhesin, CUB domain superfamily [IPR035914]", "Spermidine synthase, tetramerisation domain superfamily [IPR037163]", "Spt6, Death-like domain [IPR042066]", "Stathmin superfamily [IPR036002]", "Sterile alpha motif/pointed domain superfamily [IPR013761]", "Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain superfamily [IPR027477]", "Succinyl-CoA synthetase-like [IPR016102]", "Sulfhydryl oxidase, flavin adenine dinucleotide (FAD) binding domain superfamily [IPR042568]", "Sushi/SCR/CCP superfamily [IPR035976]", "TBP domain superfamily [IPR012295]", "TCP-1-like chaperonin intermediate domain superfamily [IPR027410]", "TEL2, C-terminal domain superfamily [IPR038528]", "TFIIS/LEDGF domain superfamily [IPR035441]", "TGS-like [IPR012676]", "TGS-like domain superfamily [IPR023192]", "TMEM14 superfamily [IPR044890]", "TRAF-like [IPR008974]", "TRF2-interacting telomeric protein/Rap1, C-terminal domain superfamily [IPR038104]", "TROVE domain superfamily [IPR037214]", "Talin, central domain superfamily [IPR036476]", "Tautomerase/MIF superfamily [IPR014347]", "Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid [IPR008930]", "Tetrapyrrole methylase superfamily [IPR035996]", "Tetrapyrrole methylase, subdomain 1 [IPR014777]", "Tetrapyrrole methylase, subdomain 2 [IPR014776]", "Tetraspanin, EC2 domain superfamily [IPR008952]", "Tetratricopeptide-like helical domain superfamily [IPR011990]", "Tex-like domain superfamily [IPR023323]", "Tex-like protein, HTH domain superfamily [IPR023319]", "Thiamin diphosphate-binding fold [IPR029061]", "Thiolase-like [IPR016039]", "Thioredoxin-like superfamily [IPR036249]", "Threonyl/alanyl tRNA synthetase, class II-like, putative editing domain superfamily [IPR018163]", "Thymidylate synthase/dCMP hydroxymethylase superfamily [IPR036926]", "Tim10-like domain superfamily [IPR035427]", "Tma16 superfamily [IPR038356]", "Toll/interleukin-1 receptor homology (TIR) domain superfamily [IPR035897]", "Transcription Factor IIF, Rap30/Rap74, interaction [IPR011039]", "Transcription elongation factor S-II, central domain superfamily [IPR036575]", "Transcription termination and cleavage factor, C-terminal domain superfamily [IPR038192]", "Transferrin receptor-like, dimerisation domain superfamily [IPR036757]", "Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II [IPR009014]", "Translation Initiation factor eIF- 4e-like [IPR023398]", "Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal [IPR009001]", "Translation elongation factor EF1B/ribosomal protein S6 [IPR014717]", "Translation elongation factor eEF-1beta-like superfamily [IPR036219]", "Translation initiation factor 2, alpha subunit, C-terminal [IPR024055]", "Translation initiation factor 2, alpha subunit, middle domain superfamily [IPR024054]", "Translation initiation factor 3, subunit 12, N-terminal, eukaryotic [IPR016020]", "Translation initiation factor IF-2, domain 3 superfamily [IPR036925]", "Translation initiation factor IF2/IF5, N-terminal [IPR016189]", "Translation initiation factor IF2/IF5, zinc-binding [IPR016190]", "Translation initiation factor eIF-2B subunit alpha, N-terminal [IPR042528]", "Translation protein SH3-like domain superfamily [IPR008991]", "Translation protein, beta-barrel domain superfamily [IPR009000]", "Translin superfamily [IPR036081]", "Translin, C-terminal [IPR016069]", "Translin, N-terminal [IPR016068]", "Trimeric LpxA-like superfamily [IPR011004]", "Triosephosphate isomerase superfamily [IPR035990]", "TspO/MBR-related superfamily [IPR038330]", "Tubulin binding cofactor A superfamily [IPR036126]", "Tubulin, C-terminal [IPR023123]", "Tubulin/FtsZ, C-terminal [IPR008280]", "Tubulin/FtsZ, GTPase domain superfamily [IPR036525]", "Tubulin/FtsZ-like, C-terminal domain [IPR037103]", "UBA-like superfamily [IPR009060]", "UROD/MetE-like superfamily [IPR038071]", "Ubiquitin activating enzyme, alpha domain superfamily [IPR023318]", "Ubiquitin-activating enzyme E1, C-terminal domain superfamily [IPR038252]", "Ubiquitin-activating enzyme E1, FCCH domain superfamily [IPR042302]", "Ubiquitin-activating enzyme E1, SCCH domain [IPR042063]", "Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 1 [IPR042449]", "Ubiquitin-activating enzyme [IPR035985]", "Ubiquitin-conjugating enzyme/RWD-like [IPR016135]", "Ubiquitin-like domain superfamily [IPR029071]", "Ubiquitin-like modifier-activating enzyme Atg7, N-terminal, subdomain 1 [IPR042522]", "Ubiquitin-like modifier-activating enzyme Atg7, N-terminal, subdomain 2 [IPR042523]", "Ubiquitin-protein ligase E3A, N-terminal zinc-binding domain superfamily [IPR042556]", "Ufd1-like, Nn domain [IPR042299]", "Uracil-DNA glycosylase-like domain superfamily [IPR036895]", "Ureohydrolase domain superfamily [IPR023696]", "V-type ATP synthase c/d subunit, domain 3 superfamily [IPR044911]", "V-type ATP synthase subunit c/d subunit superfamily [IPR036079]", "V-type ATPase subunit C/d [IPR035067]", "V-type ATPase subunit E, C-terminal domain superfamily [IPR038495]", "VASP tetramerisation domain superfamily [IPR038023]", "VKOR domain superfamily [IPR038354]", "VPS9 domain superfamily [IPR037191]", "Vacuolar ATP synthase subunit C superfamily [IPR036132]", "Vacuolar protein sorting-associated protein 33, domain 3b [IPR043155]", "Vacuolar protein sorting-associated protein 35, C-terminal [IPR042491]", "Vacuolar protein sorting-associated protein IST1-like [IPR042277]", "Valyl-tRNA synthetase, tRNA-binding arm superfamily [IPR037118]", "Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain [IPR009008]", "Vanillyl-alcohol oxidase, C-terminal subdomain 2 [IPR016171]", "Vitamin B12-dependent methionine synthase, activation domain superfamily [IPR037010]", "Vps16, C-terminal domain superfamily [IPR038132]", "Vps53, C-terminal domain superfamily [IPR038260]", "WD40-repeat-containing domain superfamily [IPR036322]", "WD40/YVTN repeat-like-containing domain superfamily [IPR015943]", "WGR domain superfamily [IPR036930]", "WW domain superfamily [IPR036020]", "WWE domain superfamily [IPR037197]", "Winged helix DNA-binding domain superfamily [IPR036390]", "Winged helix-like DNA-binding domain superfamily [IPR036388]", "XPC-binding domain superfamily [IPR036353]", "YjeF N-terminal domain superfamily [IPR036652]", "YqgF/RNase H-like domain superfamily [IPR037027]", "ZPR1, A/B domain [IPR042451]", "ZPR1, zinc finger domain [IPR042452]", "Zinc finger C2H2 superfamily [IPR036236]", "Zinc finger, C2H2C-type superfamily [IPR036060]", "Zinc finger, CCCH-type superfamily [IPR036855]", "Zinc finger, CCHC-type superfamily [IPR036875]", "Zinc finger, FYVE/PHD-type [IPR011011]", "Zinc finger, NHR/GATA-type [IPR013088]", "Zinc finger, PARP-type superfamily [IPR036957]", "Zinc finger, RING/FYVE/PHD-type [IPR013083]", "Zinc finger, RanBP2-type superfamily [IPR036443]", "Zinc finger, Sec23/Sec24-type superfamily [IPR036174]", "Zinc finger, ZZ-type superfamily [IPR043145]", "Zinc-binding ribosomal protein [IPR011332]", "dUTPase-like superfamily [IPR036157]", "eRF1, domain 1 [IPR024049]", "eRF1, domain 2 superfamily [IPR042226]", "p53-like tetramerisation domain superfamily [IPR036674]", "p53-like transcription factor, DNA-binding [IPR008967]", "p53/RUNT-type transcription factor, DNA-binding domain superfamily [IPR012346]", "rRNA adenine dimethylase-like, C-terminal [IPR023165]", "ssDNA-binding transcriptional regulator [IPR009044]", "tRNA (guanine-N1-)-methyltransferase, N-terminal [IPR029026]", "tRNA methyltransferase TRM10-type domain superfamily [IPR038459]", "tRNA methyltransferase, Trm1, C-terminal [IPR042296]", "tRNA modification GTPase MnmE domain 2 [IPR027368]", "tRNA-splicing ligase RtcB-like superfamily [IPR036025]", "von Willebrand factor A-like domain superfamily [IPR036465]"], "available_proteins": ["AAAS", "AAMP", "AAR2", "AARS", "AARS2", "AASDHPPT", "AASS", "ABCB1", "ABCB7", "ABCC1", "ABCD3", "ABCE1", "ABCF1", "ABCF2", "ABCF3", "ABHD10", "ABHD12", "ABHD14B", "ABHD6", "ABI1", "ACAA2", "ACACA", "ACACB", "ACAD11", "ACAD9", "ACADM", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACBD5", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT9", "ACOX1", "ACOX3", "ACP1", "ACP2", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN4", "ACTR10", "ACTR1A", "ACTR1B", "ACTR2", "ACTR3", "ADAR", "ADD1", "ADD3", "ADH5", "ADI1", "ADNP", "ADPGK", "ADPRHL2", "ADRM1", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGK", "AGL", "AGPS", "AHCY", "AHCYL1", "AHNAK", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AKAP13", "AKR1A1", "AKR1B1", "AKR7A2", "AKT2", "ALDH18A1", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALKBH5", "ALYREF", "ANAPC1", "ANAPC2", "ANAPC5", "ANAPC7", "ANGEL1", "ANKFY1", "ANKHD1", "ANKLE2", "ANKRD17", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA3", "ANXA4", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP1M1", "AP1S2", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "AP3S1", "APEH", "APEX1", "API5", "APLP2", "APMAP", "APP", "APRT", "AQR", "ARAF", "ARCN1", "ARF4", "ARF6", "ARFGAP1", "ARFGAP2", "ARFIP1", "ARFIP2", "ARHGAP1", "ARHGAP17", "ARHGDIA", "ARHGEF1", "ARHGEF2", "ARID1A", "ARID3B", "ARIH1", "ARIH2", "ARL1", "ARL10", "ARL2", "ARL3", "ARMC10", "ARMC6", "ARMC8", "ARMCX3", "ARMT1", "ARPC1A", "ARPC2", "ARPC3", "ARPC4", "ARPC5", "ASCC2", "ASCC3", "ASNA1", "ASNS", "ASPH", "ATAD1", "ATAD2", "ATAD3A", "ATAD3B", "ATE1", "ATG4B", "ATG7", "ATIC", "ATL2", "ATP13A1", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5H", "ATP5O", "ATP6", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1E1", "ATP6V1H", "ATP7B", "ATXN10", "AURKA", "AURKB", "BABAM1", "BAG4", "BAG5", "BAG6", "BAIAP2", "BAK1", "BANF1", "BAZ1A", "BAZ1B", "BCL2L13", "BCS1L", "BIRC6", "BLMH", "BLVRA", "BMS1", "BOLA2*", "BOP1", "BPHL", "BRAP", "BRAT1", "BRD2", "BSDC1", "BSG", "BTAF1", "BTF3", "BUB1B", "BUB3", "BUD23", "BZW1", "BZW2", "C1QBP", "C2CD5", "CAB39", "CACUL1", "CACYBP", "CAD", "CALM3", "CALR", "CALU", "CAMK1", "CAMK2G", "CAND1", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPZA1", "CAPZA2", "CAPZB", "CARM1", "CARS", "CARS2", "CASK", "CBR1", "CBX1", "CBX3", "CBX5", "CBX8", "CCAR1", "CCAR2", "CCNB1", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2AP", "CD2BP2", "CD320", "CD47", "CDC16", "CDC20", "CDC23", "CDC27", "CDC34", "CDC37", "CDC40", "CDC42", "CDC5L", "CDC7", "CDC73", "CDH2", "CDIPT", "CDK1", "CDK2", "CDK4", "CDK5", "CDK6", "CDKAL1", "CDKN2A", "CEBPZ", "CECR2", "CELF2", "CENPV", "CERS2", "CETN2", "CFL1", "CFL2", "CHAC2", "CHAF1B", "CHAMP1", "CHD1", "CHD1L", "CHD4", "CHERP", "CHID1", "CHKA", "CHORDC1", "CHRAC1", "CHTF18", "CIAPIN1", "CIP2A", "CIRBP", "CISD1", "CISD2", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLCN3", "CLCN7", "CLGN", "CLIC1", "CLIC4", "CLINT1", "CLNS1A", "CLPB", "CLPP", "CLPX", "CLTC", "CLUH", "CMAS", "CMPK1", "CMSS1", "CMTR1", "CNN3", "CNNM4", "CNOT1", "CNOT10", "CNOT2", "CNOT9", "CNP", "COA7", "COASY", "COLEC12", "COLGALT1", "COMT", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS2", "COPS3", "COPS4", "COPZ1", "COQ8A", "CORO1B", "CORO1C", "CORO7", "COTL1", "COX2", "COX4I1", "COX5A", "COX5B", "COX6C", "COX7A2", "CPD", "CPNE1", "CPNE3", "CPOX", "CPSF1", "CPSF2", "CPSF3", "CPSF6", "CPSF7", "CPT1A", "CPT2", "CPVL", "CRK", "CRKL", "CRNKL1", "CROT", "CRTAP", "CRYZL1", "CS", "CSDE1", "CSE1L", "CSK", "CSNK1A1", "CSNK2A2", "CSNK2B", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTCF", "CTDSPL2", "CTNNA1", "CTNNAL1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTPS2", "CTR9", "CTSA", "CTSB", "CTSC", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CUTA", "CWC27", "CWF19L1", "CXorf57", "CYB5B", "CYB5D2", "CYB5R1", "CYB5R3", "CYC1", "CYP20A1", "CYP51A1", "DAG1", "DAP3", "DARS", "DARS2", "DAXX", "DAZAP1", "DBN1", "DBNL", "DBT", "DCAF13", "DCAF7", "DCAKD", "DCP1B", "DCPS", "DCTD", "DCTN1", "DCUN1D1", "DCUN1D5", "DCXR", "DDB1", "DDI2", "DDRGK1", "DDT", "DDX1", "DDX10", "DDX17", "DDX18", "DDX20", "DDX21", "DDX23", "DDX24", "DDX27", "DDX28", "DDX39A", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX50", "DDX51", "DDX52", "DDX54", "DDX55", "DDX56", "DDX6", "DENR", "DERL1", "DERL2", "DFFA", "DGKE", "DHCR24", "DHFR", "DHPS", "DHRS1", "DHRS4", "DHRS7", "DHRS7B", "DHX15", "DHX16", "DHX29", "DHX30", "DHX36", "DHX37", "DHX38", "DHX40", "DHX57", "DHX8", "DHX9", "DIABLO", "DIAPH1", "DIAPH2", "DIAPH3", "DIDO1", "DIMT1", "DIS3", "DKC1", "DLAT", "DLD", "DLG3", "DLST", "DNAAF5", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC13", "DNAJC19", "DNAJC2", "DNAJC3", "DNAJC7", "DNAJC8", "DNAJC9", "DNM1L", "DNM2", "DNMT1", "DOCK7", "DOHH", "DOLPP1", "DPH2", "DPH5", "DPM1", "DPP9", "DPYSL2", "DPYSL5", "DRG1", "DRG2", "DSC3", "DSG2", "DSP", "DST", "DSTN", "DTYMK", "DUSP12", "DUSP3", "DUSP9", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNC1LI2", "DYNLL2", "EARS2", "ECE1", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "EDC3", "EDC4", "EDF1", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EFCAB14", "EFL1", "EFTUD2", "EHD1", "EHD4", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B5", "EIF2D", "EIF2S1", "EIF2S2", "EIF3B", "EIF3E", "EIF3G", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "ELAC2", "ELAVL1", "ELMO2", "ELOA", "ELOB", "ELOC", "ELP1", "ELP2", "ELP3", "EMC1", "EMC2", "EMC7", "EMD", "EMG1", "EML4", "ENAH", "ENDOD1", "ENO1", "ENO2", "ENOPH1", "EPB41", "EPB41L2", "EPB41L3", "EPB41L5", "EPHA7", "EPHX1", "EPHX2", "EPPK1", "EPRS", "EPS15L1", "ERAL1", "ERAP1", "ERC1", "ERCC2", "ERCC3", "ERCC6L", "ERH", "ERLIN1", "ERLIN2", "ERO1A", "ERP29", "ERP44", "ESD", "ESF1", "ESYT1", "ESYT2", "ETF1", "ETFA", "ETFB", "ETFDH", "ETNK1", "EWSR1", "EXO1", "EXOC2", "EXOC3", "EXOC6", "EXOC6B", "EXOC7", "EXOC8", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC9", "EZR", "F11R", "FABP5", "FADS2", "FAF1", "FAF2", "FAH", "FAHD1", "FAR1", "FARP1", "FARS2", "FARSA", "FARSB", "FASN", "FBL", "FBXO21", "FBXO22", "FCGRT", "FDFT1", "FDPS", "FDXR", "FEN1", "FERMT2", "FH", "FHOD1", "FIS1", "FKBP10", "FKBP14", "FKBP4", "FKBP5", "FKBP7", "FKBP8", "FKBP9", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FMR1", "FN3KRP", "FNTB", "FOXRED1", "FSCN1", "FTL", "FTO", "FTSJ3", "FUBP1", "FUBP3", "FUCA1", "FUCA2", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GADD45GIP1", "GAK", "GALK1", "GALNT1", "GALNT2", "GALNT4", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2B", "GBA", "GBE1", "GBF1", "GCAT", "GCDH", "GCLC", "GCN1", "GDAP1", "GDI1", "GDI2", "GDPD1", "GEMIN5", "GET4", "GFM1", "GFPT1", "GGCT", "GGCX", "GGH", "GGPS1", "GIGYF2", "GINS2", "GINS3", "GINS4", "GLA", "GLB1", "GLDC", "GLO1", "GLOD4", "GLRX3", "GLS", "GLT8D1", "GLUD1", "GLYR1", "GM2A", "GMFB", "GMPPB", "GMPS", "GNA13", "GNAI2", "GNAI3", "GNG12", "GNL2", "GNL3", "GNL3L", "GNPDA1", "GNS", "GOLPH3", "GOPC", "GORASP2", "GOT1", "GOT2", "GPATCH8", "GPD2", "GPHN", "GPI", "GPKOW", "GPS1", "GPT2", "GRAMD1A", "GRB2", "GRHPR", "GRPEL1", "GRSF1", "GRWD1", "GSPT1", "GSR", "GSS", "GSTK1", "GSTM3", "GSTO1", "GTF2B", "GTF2E1", "GTF2F1", "GTF2I", "GTF3C2", "GTF3C3", "GTPBP1", "GTPBP10", "GTPBP3", "GTPBP4", "GUF1", "GYG1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACD3", "HACL1", "HADH", "HADHA", "HADHB", "HAT1", "HBS1L", "HCFC1", "HDAC1", "HDAC2", "HDGFL2", "HDHD2", "HDHD5", "HDLBP", "HEATR1", "HEATR3", "HEATR6", "HEBP1", "HEBP2", "HECTD1", "HELLS", "HEXA", "HEXB", "HGH1", "HGS", "HIBADH", "HIBCH", "HINT2", "HINT3", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLTF", "HMBS", "HMCES", "HMGB1", "HMGB2", "HMGB3", "HMGCL", "HMGCR", "HMGCS1", "HMOX1", "HMOX2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPLL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HNRNPUL2", "HP1BP3", "HPRT1", "HS2ST1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSDL1", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA13", "HSPA14", "HSPA1B", "HSPA2", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPB1", "HSPBP1", "HSPD1", "HSPE1", "HSPH1", "HTATSF1", "HTRA2", "HUWE1", "HYOU1", "IARS", "IARS2", "IDE", "IDI1", "IFT27", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "ILF2", "ILF3", "ILK", "ILKAP", "ILVBL", "IMP3", "IMPDH1", "IMPDH2", "INTS11", "INTS14", "INTS7", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IQGAP2", "IRS4", "ISOC1", "IST1", "ITCH", "ITGB1", "ITPA", "IVD", "JUP", "KARS", "KAT7", "KCTD12", "KCTD5", "KDELC2", "KDM1A", "KDM1B", "KDM2A", "KDSR", "KHDRBS1", "KHSRP", "KIAA0319L", "KIAA0368", "KIAA0391", "KIAA1468", "KIF11", "KIF14", "KIF15", "KIF18B", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF4A", "KIF5B", "KIFBP", "KIFC1", "KIN", "KLC1", "KLC2", "KLC4", "KMT2A", "KNTC1", "KPNA1", "KPNA2", "KPNA3", "KPNA6", "KPNB1", "KRR1", "L1RE1", "L2HGDH", "LANCL2", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LASP1", "LDAH", "LDHA", "LDHB", "LEMD2", "LEMD3", "LETM1", "LGALS3BP", "LIG1", "LIG3", "LIPA", "LMAN2", "LMNA", "LMNB1", "LMNB2", "LNPEP", "LONP1", "LPCAT1", "LRBA", "LRP1", "LRPAP1", "LRPPRC", "LRRC1", "LRRC40", "LRRC47", "LRRC59", "LRWD1", "LSM2", "LSM3", "LSM4", "LSM6", "LSM7", "LSS", "LTA4H", "LYAR", "LYPLA1", "LYSMD3", "LZIC", "M6PR", "MACF1", "MAD2L1", "MAGED2", "MAGT1", "MAN1A1", "MAN2A1", "MAN2B1", "MANF", "MAP2K2", "MAPK1", "MAPK14", "MAPRE1", "MAPRE2", "MARC1", "MARCH5", "MARS", "MASTL", "MAT2A", "MAT2B", "MATR3", "MAU2", "MAVS", "MBD3", "MCAT", "MCCC1", "MCCC2", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCTS1", "MDC1", "MDH1", "MDH2", "MDN1", "ME1", "ME2", "MECP2", "MED21", "MED25", "MEPCE", "METAP2", "METTL13", "METTL14", "METTL3", "METTL7A", "METTL7B", "METTL9", "MFN1", "MFN2", "MFSD3", "MFSD5", "MGEA5", "MGME1", "MGST2", "MGST3", "MIA2", "MIA3", "MICU1", "MICU2", "MIF", "MINDY3", "MIPEP", "MKI67", "MKRN2", "MMAB", "MMS19", "MOB4", "MOGS", "MORF4L1", "MOSPD2", "MOV10", "MPG", "MPI", "MPP1", "MPP6", "MPRIP", "MPST", "MRC2", "MRE11", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL14", "MRPL15", "MRPL17", "MRPL19", "MRPL21", "MRPL22", "MRPL23", "MRPL24", "MRPL28", "MRPL3", "MRPL38", "MRPL39", "MRPL44", "MRPL45", "MRPL46", "MRPL55", "MRPL9", "MRPS11", "MRPS15", "MRPS16", "MRPS18A", "MRPS25", "MRPS27", "MRPS5", "MRPS7", "MRPS9", "MRRF", "MRTO4", "MSH2", "MSH3", "MSH6", "MSI2", "MSN", "MSTO1", "MTA1", "MTA2", "MTAP", "MTCH1", "MTCH2", "MTHFD1", "MTHFD1L", "MTHFD2", "MTMR14", "MTMR2", "MTOR", "MTPAP", "MTPN", "MTR", "MTX1", "MTX2", "MUT", "MVK", "MYBBP1A", "MYEF2", "MYH10", "MYH9", "MYL6", "MYO1B", "MYO1C", "MYO1D", "MYO6", "NAA15", "NAA25", "NAA40", "NAA50", "NADK2", "NAE1", "NAF1", "NAGA", "NAGLU", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NAPG", "NARS", "NASP", "NAT10", "NAXE", "NCAPD2", "NCAPD3", "NCAPG", "NCAPG2", "NCBP1", "NCBP3", "NCDN", "NCL", "NDUFA9", "NDUFAF3", "NDUFAF7", "NDUFS1", "NDUFS3", "NDUFV1", "NDUFV2", "NECAP2", "NEK9", "NELFE", "NENF", "NFATC2IP", "NFU1", "NHP2", "NIFK", "NIP7", "NIPSNAP1", "NIPSNAP2", "NKRF", "NKTR", "NLE1", "NLN", "NLRX1", "NME1", "NMT1", "NNT", "NOA1", "NOB1", "NOC2L", "NOC3L", "NOC4L", "NOL10", "NOL11", "NOL8", "NOL9", "NOM1", "NONO", "NOP2", "NOP56", "NOP58", "NOP9", "NOSIP", "NPC2", "NPEPPS", "NPLOC4", "NPM1", "NRDC", "NSD2", "NSDHL", "NSF", "NSMCE2", "NSUN2", "NSUN5", "NT5C2", "NT5C3B", "NT5DC1", "NT5DC2", "NTHL1", "NTMT1", "NTPCR", "NUB1", "NUBP2", "NUBPL", "NUCB1", "NUCB2", "NUDC", "NUDCD1", "NUDCD2", "NUDT1", "NUDT16L1", "NUDT21", "NUDT5", "NUDT9", "NUF2", "NUP133", "NUP153", "NUP155", "NUP188", "NUP210", "NUP214", "NUP35", "NUP37", "NUP43", "NUP50", "NUP98", "NUTF2", "NVL", "NXF1", "NXN", "OAT", "OCLN", "OCRL", "OGDH", "OGT", "OLA1", "OPA1", "OSBP", "OSBPL3", "OSBPL6", "OSBPL8", "OSBPL9", "OSGEP", "OTUB1", "OTUD4", "OXCT1", "OXSR1", "P3H1", "P3H4", "P4HA1", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PAFAH1B1", "PAFAH1B2", "PAFAH1B3", "PAIP1", "PAK1IP1", "PAK2", "PALLD", "PANK4", "PAPOLA", "PARK7", "PARN", "PARP1", "PBDC1", "PBK", "PBRM1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCID2", "PCK2", "PCMT1", "PCYOX1", "PDCD11", "PDCD5", "PDCD6", "PDCD6IP", "PDCL3", "PDE12", "PDE6D", "PDHA1", "PDHB", "PDIA3", "PDIA4", "PDIA5", "PDIA6", "PDK3", "PDLIM1", "PDLIM5", "PDLIM7", "PDPR", "PDS5A", "PDS5B", "PDXDC1", "PDXK", "PEBP1", "PECR", "PEF1", "PELO", "PELP1", "PEPD", "PES1", "PEX14", "PEX19", "PEX5", "PFAS", "PFDN2", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGM3", "PGP", "PGRMC1", "PGRMC2", "PHAX", "PHB", "PHB2", "PHC2", "PHF6", "PHGDH", "PHIP", "PHKA1", "PI4KB", "PICALM", "PIK3R4", "PIP4K2C", "PIR", "PITHD1", "PITPNB", "PITRM1", "PKM", "PKMYT1", "PKN1", "PKN2", "PLA2G15", "PLAA", "PLBD2", "PLCG1", "PLEC", "PLK1", "PLOD1", "PLOD2", "PLPBP", "PLRG1", "PLS3", "PM20D2", "PMPCA", "PMPCB", "PMVK", "PNKP", "PNO1", "PNP", "PNPLA6", "PNPT1", "POGZ", "POLA1", "POLA2", "POLD1", "POLD3", "POLDIP2", "POLDIP3", "POLE", "POLE3", "POLE4", "POLR1A", "POLR1B", "POLR1C", "POLR2A", "POLR2B", "POLR2C", "POLR2D", "POLR2E", "POLR2F", "POLR2G", "POLR2L", "POLR3A", "POLR3C", "POLRMT", "PON2", "POR", "PPA1", "PPA2", "PPAT", "PPIB", "PPIC", "PPID", "PPIF", "PPIH", "PPIL1", "PPIL3", "PPIL4", "PPM1G", "PPME1", "PPOX", "PPP1CA", "PPP1CB", "PPP1R10", "PPP1R12A", "PPP1R8", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP2R5E", "PPP3CA", "PPP4C", "PPP4R1", "PPP4R3A", "PPP5C", "PPP6C", "PPP6R3", "PPT1", "PPT2", "PPWD1", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PREP", "PREPL", "PRKAA2", "PRKACA", "PRKAR1A", "PRKAR2A", "PRKCB", "PRKCSH", "PRKDC", "PRMT1", "PRMT3", "PRMT5", "PRMT9", "PRPF19", "PRPF31", "PRPF39", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPSAP1", "PRPSAP2", "PRRC1", "PRTFDC1", "PSAP", "PSAT1", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD12", "PSMD13", "PSMD2", "PSMD3", "PSMD4", "PSMD6", "PSMD9", "PSME1", "PSME2", "PSME3", "PSME4", "PSPC1", "PTBP1", "PTCD3", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK7", "PTPA", "PTPMT1", "PTPN1", "PTPN11", "PTPRF", "PTRH2", "PUDP", "PUF60", "PUM1", "PUM3", "PUS7", "PWP1", "PWP2", "PYCR1", "PYCR2", "PYCR3", "QARS", "QKI", "QRSL1", "QSOX2", "QTRT2", "RAB10", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB1B", "RAB21", "RAB24", "RAB31", "RAB39A", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RAB8A", "RAB9A", "RABEPK", "RABGAP1", "RABL6", "RAC1", "RACGAP1", "RACK1", "RAD21", "RAD23A", "RAD23B", "RAD50", "RAE1", "RAI14", "RALA", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP6", "RANBP9", "RANGAP1", "RAP2B", "RAPGEF2", "RARS", "RARS2", "RAVER1", "RBBP5", "RBBP6", "RBBP7", "RBM10", "RBM12", "RBM14", "RBM17", "RBM19", "RBM22", "RBM25", "RBM26", "RBM27", "RBM28", "RBM34", "RBM39", "RBM4", "RBM5", "RBM6", "RBM8A", "RBMX", "RBP1", "RCC1", "RCC2", "RCL1", "RCN1", "RCN2", "RDH11", "RDH13", "RDH14", "RDX", "RECQL", "RETSAT", "REXO4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RHBDD2", "RHEB", "RHOG", "RHOT1", "RHOT2", "RIDA", "RIF1", "RINT1", "RMC1", "RMDN1", "RMDN3", "RNASEH2A", "RNASET2", "RNF139", "RNF14", "RNF20", "RNF219", "RNF40", "RNH1", "RNPEP", "ROCK1", "RPA1", "RPA2", "RPAP3", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL3", "RPL30", "RPL31", "RPL32", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPP30", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS28", "RPS29", "RPS3", "RPS4X", "RPS5", "RPS6KA1", "RPS6KA3", "RPS8", "RPS9", "RPSA", "RPTOR", "RPUSD3", "RRM1", "RRM2", "RRP12", "RRP8", "RRP9", "RSL1D1", "RSL24D1", "RSPRY1", "RSU1", "RTCB", "RTN4IP1", "RUFY1", "RUVBL1", "RUVBL2", "S100A11", "S100A13", "SAAL1", "SAE1", "SAFB", "SAFB2", "SAMD4B", "SAMHD1", "SAP18", "SAR1A", "SARM1", "SARNP", "SARS", "SARS2", "SART3", "SBDS", "SCAF4", "SCCPDH", "SCFD1", "SCML2", "SCO1", "SCO2", "SCP2", "SCPEP1", "SCRIB", "SDAD1", "SDCBP", "SDF4", "SDHA", "SDHB", "SDR39U1", "SEC11A", "SEC22B", "SEC23A", "SEC23B", "SEC23IP", "SEC24A", "SEC24B", "SEC24C", "SEC24D", "SEC31A", "SEC61A1", "SEC61G", "SEC63", "SEH1L", "SEL1L", "SENP3", "SEPHS1", "SEPT11", "SEPT2", "SEPT6", "SEPT7", "SEPT9", "SERPINB6", "SERPINH1", "SET", "SEZ6L2", "SF1", "SF3A1", "SF3A2", "SF3B1", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SGPL1", "SGTA", "SH3GL1", "SH3GLB1", "SH3GLB2", "SHMT1", "SHMT2", "SIN3A", "SIRT1", "SKIV2L", "SKIV2L2", "SKP1", "SKP2", "SLC16A1", "SLC19A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A17", "SLC25A19", "SLC25A20", "SLC25A21", "SLC25A22", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A33", "SLC25A4", "SLC25A40", "SLC25A42", "SLC25A5", "SLC25A6", "SLC27A4", "SLC30A5", "SLC30A6", "SLC33A1", "SLC3A2", "SLC4A1AP", "SLC4A7", "SLC6A15", "SLC9A3R1", "SLFN11", "SLIRP", "SLIT2", "SLK", "SLTM", "SMAP1", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC6", "SMG5", "SMS", "SMU1", "SMYD3", "SND1", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPC", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNX1", "SNX12", "SNX17", "SNX19", "SNX2", "SNX27", "SNX3", "SNX4", "SNX5", "SNX6", "SNX9", "SOD2", "SON", "SORD", "SPAG9", "SPART", "SPATA5", "SPATA5L1", "SPECC1L", "SPEN", "SPHK2", "SPNS1", "SPR", "SPTAN1", "SPTBN1", "SPTBN2", "SPTLC1", "SPTLC2", "SQLE", "SQSTM1", "SRCAP", "SREK1", "SRI", "SRM", "SRP14", "SRP54", "SRP68", "SRP72", "SRP9", "SRPK1", "SRPK2", "SRPRA", "SRPRB", "SRRM1", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF3", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSRP1", "STAG1", "STAG2", "STAM", "STARD3", "STARD7", "STAT1", "STAT3", "STIM1", "STIP1", "STK26", "STK4", "STMN1", "STOM", "STOML2", "STRAP", "STRBP", "STRN", "STX10", "STX12", "STX3", "STX4", "STX5", "STX7", "STXBP3", "STXBP4", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGP2", "SUGT1", "SUPT16H", "SUPT5H", "SUPT6H", "SUPV3L1", "SV2A", "SYAP1", "SYMPK", "SYNCRIP", "SYNE2", "SYNJ2BP", "TAB1", "TAF15", "TAF6L", "TAGLN2", "TALDO1", "TAOK1", "TAP1", "TARDBP", "TARS", "TARS2", "TBC1D13", "TBC1D15", "TBC1D2B", "TBC1D4", "TBC1D9B", "TBCA", "TBCB", "TBCD", "TBCE", "TBL2", "TBL3", "TCAF1", "TCEA1", "TCERG1", "TCP1", "TDRKH", "TECR", "TELO2", "TERF2IP", "TEX10", "TEX264", "TFAM", "TFB1M", "TFCP2", "TFRC", "THOC1", "THOC3", "THOC6", "THOP1", "THUMPD3", "THYN1", "TIA1", "TIAL1", "TIGAR", "TIMM10", "TIMM10B", "TIMM13", "TIMM44", "TIMM50", "TIMM8B", "TIMM9", "TJP1", "TK1", "TKT", "TLN1", "TMA16", "TMED2", "TMED5", "TMED7", "TMEM14C", "TMOD1", "TMOD3", "TMPO", "TMPO", "TMPPE", "TMTC3", "TMX1", "TMX2", "TMX3", "TMX4", "TNPO1", "TNPO2", "TNPO3", "TOE1", "TOMM20", "TOMM34", "TOMM40", "TOMM70", "TOP1", "TOP2A", "TOP2B", "TOR1AIP1", "TOR1B", "TOR3A", "TOX4", "TP53", "TPD52L2", "TPI1", "TPM4", "TPP1", "TPP2", "TPT1", "TRA2A", "TRA2B", "TRAF2", "TRAP1", "TRAPPC5", "TRIM21", "TRIM25", "TRIM28", "TRIM33", "TRIP12", "TRIP13", "TRMT10C", "TRMT11", "TRMT1L", "TRMT2A", "TRMU", "TROVE2", "TRRAP", "TRUB1", "TSFM", "TSG101", "TSN", "TSNAX", "TSPAN10", "TSPAN3", "TSPAN6", "TSPO", "TST", "TTC1", "TTC19", "TTC26", "TTC37", "TTC38", "TTC4", "TTK", "TUBB", "TUBB2A", "TUBB2B", "TUBB3", "TUBB4B", "TUBB6", "TUBGCP2", "TUBGCP3", "TUBGCP4", "TUFM", "TWF1", "TWF2", "TWISTNB", "TWNK", "TXNDC12", "TXNDC17", "TXNDC5", "TXNDC9", "TXNL1", "TXNRD1", "TYMS", "U2AF1", "U2AF2", "U2SURP", "UAP1", "UBA1", "UBA2", "UBA3", "UBA6", "UBAC1", "UBAP2L", "UBE2J1", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2O", "UBE2S", "UBE3A", "UBE4A", "UBE4B", "UBLCP1", "UBP1", "UBQLN2", "UBQLN4", "UBR4", "UBR5", "UBTF", "UBXN1", "UBXN4", "UBXN7", "UCHL5", "UCK2", "UFC1", "UFD1", "UFM1", "UGCG", "UGGT1", "UGP2", "UHRF1", "ULK3", "UMPS", "UNC119", "UNC119B", "UNC45A", "UNG", "UPF1", "UQCR10", "UQCRB", "UQCRC1", "UQCRC2", "UQCRQ", "URB1", "UROD", "USO1", "USP10", "USP11", "USP14", "USP28", "USP36", "USP39", "USP47", "USP48", "USP5", "USP7", "USP9X", "UTP15", "UTP18", "UTP20", "UTP4", "UTP6", "UTRN", "UXT", "VAMP7", "VAPA", "VAPB", "VARS1", "VAT1", "VBP1", "VCL", "VCP", "VDAC1", "VDAC2", "VDAC3", "VIRMA", "VKORC1L1", "VPS13D", "VPS16", "VPS26A", "VPS29", "VPS33A", "VPS33B", "VPS35", "VPS37B", "VPS4A", "VPS4B", "VPS51", "VPS53", "VRK1", "VRK3", "WAPL", "WARS", "WDHD1", "WDR1", "WDR11", "WDR12", "WDR18", "WDR26", "WDR3", "WDR34", "WDR36", "WDR41", "WDR43", "WDR46", "WDR48", "WDR5", "WDR6", "WDR61", "WDR70", "WDR75", "WDR77", "WDR82", "WFS1", "WIPI2", "WIZ", "XAB2", "XPNPEP1", "XPNPEP3", "XPO1", "XPO4", "XPO5", "XPO7", "XPOT", "XRCC1", "XRCC5", "XRCC6", "YARS", "YARS2", "YBX1", "YBX3", "YKT6", "YLPM1", "YME1L1", "YRDC", "YTHDC2", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2", "ZC3H15", "ZC3H18", "ZC3HAV1", "ZCCHC3", "ZCRB1", "ZDHHC13", "ZFR", "ZFYVE16", "ZNF280C", "ZNF281", "ZNF512", "ZNF512B", "ZNF622", "ZNF638", "ZPR1", "ZRANB2"], "leading_proteins": ["ABCB1", "ABCB7", "ABCC1", "ABHD10", "ACAT2", "ACSF3", "ACSL1", "ACSL3", "ADD3", "AGK", "AIFM1", "ANAPC5", "ANAPC7", "ANKLE2", "APLP2", "ATIC", "ATP13A1", "ATP1A1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP5B", "ATP7B", "BAG4", "BCL2L13", "BSG", "CALU", "CD47", "CDC16", "CDC27", "CENPV", "CLCN7", "CLUH", "CPVL", "CRTAP", "CTDSPL2", "CTSA", "CYB5B", "CYB5R1", "CYP51A1", "DERL2", "DHCR24", "DNAJA2", "DNAJA3", "DUSP9", "ECE1", "EFCAB14", "EIF3L", "EMC2", "ENOPH1", "EPHX1", "ERAP1", "ERLIN1", "EXOC6B", "FADS2", "FASN", "FIS1", "FKBP10", "FKBP14", "FKBP7", "FKBP9", "FLOT1", "FLOT2", "FOXRED1", "FUCA2", "GAA", "GALNT4", "GBA", "GGCX", "GLA", "GLB1", "GPHN", "HACD3", "HLA-A", "HLA-B", "HLA-C", "HMOX2", "HSDL2", "ILVBL", "ITCH", "KDM1B", "KIAA0319L", "KIAA0391", "KIFBP", "KPNA3", "L2HGDH", "LDAH", "LEMD3", "LETM1", "LMNA", "LMNB1", "LNPEP", "LPCAT1", "MAPRE1", "MAU2", "ME1", "MFSD3", "MGST2", "MICU2", "MIPEP", "MOGS", "MOSPD2", "MPST", "MRPS11", "MRPS7", "MTCH1", "MTCH2", "NAGA", "NAGLU", "NAP1L1", "NAPA", "NASP", "NIP7", "NIPSNAP1", "NLN", "NT5C3B", "NUCB1", "NUCB2", "OLA1", "P3H1", "P3H4", "P4HA1", "PCYOX1", "PDPR", "PEBP1", "PEX5", "PFDN2", "PFDN6", "PFN2", "PGRMC1", "PGRMC2", "PHB", "PHB2", "PHKA1", "PITRM1", "PLA2G15", "PMPCA", "PNPLA6", "POLRMT", "POR", "PPT1", "PPT2", "PRCP", "PREPL", "PRPF40A", "PSMB2", "PSMB4", "PSMD11", "RARS", "RCN2", "RETSAT", "RHBDD2", "RMDN1", "RPL37", "RPL37A", "RRM2", "RUVBL2", "SCFD1", "SCPEP1", "SDF4", "SDHB", "SEC23B", "SEL1L", "SET", "SGPL1", "SH3GLB1", "SLC16A1", "SLC19A1", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A17", "SLC25A19", "SLC25A20", "SLC25A21", "SLC25A22", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A33", "SLC25A4", "SLC25A42", "SLC25A5", "SLC25A6", "SLC27A4", "SLC30A6", "SLC33A1", "SMG5", "SMYD3", "SNX4", "SNX5", "SPHK2", "SQLE", "SQSTM1", "STARD3", "STOM", "STOML2", "STX10", "STX12", "STX4", "STX5", "STXBP3", "STXBP4", "SV2A", "TAP1", "TARS2", "TIMM10B", "TIMM50", "TIMM8B", "TIMM9", "TMED2", "TMPO", "TMTC3", "TSG101", "TSPAN3", "TSPAN6", "TTC19", "TTC26", "TTC37", "TTC38", "UGCG", "UNC119", "UNC119B", "UQCRC2", "UTP6", "UTRN", "UXT", "VBP1", "VDAC1", "VDAC2", "VDAC3", "VPS33A", "WFS1"]} \ No newline at end of file diff --git a/interpro_ptm/advanced/idx2term.json b/interpro_ptm/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..9e26dfeeb6e641a33dae4961196235bdb965b21b --- /dev/null +++ b/interpro_ptm/advanced/idx2term.json @@ -0,0 +1 @@ +{} \ No newline at end of file diff --git a/interpro_ptm/basic/idx2term.json b/interpro_ptm/basic/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..9e26dfeeb6e641a33dae4961196235bdb965b21b --- /dev/null +++ b/interpro_ptm/basic/idx2term.json @@ -0,0 +1 @@ +{} \ No newline at end of file diff --git a/interpro_ptm/consensus.joblib b/interpro_ptm/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..bd15979df8407faba7ab0b3e61ef707248c27eba --- /dev/null +++ b/interpro_ptm/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:6f3f47aaf2df86e53aa725c24b16bcf4f1b3aa8254dfd0b60e5804a2ee68e6db +size 66655 diff --git a/interpro_ptm/df_merge.tsv b/interpro_ptm/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..d6ac3afa5ddb7238c6d0804bdeddfa16423db0c0 --- /dev/null +++ b/interpro_ptm/df_merge.tsv @@ -0,0 +1,2 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +P-type ATPase, phosphorylation site [IPR018303] 4 5 2.063733772997012 0.039042965342845 2.941747572815534 6.145631067961165 0.9567723497044874 0.2732808833570771 1.8358630293390923 1.459204245106796 1.2102525517005158 0.2943240638910574 0.0167170186699105 1.0 1.0 0.4108142183097444 0.0184399659986801 diff --git a/interpro_ptm/metrics.json b/interpro_ptm/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..3d3788f8dc42d17d1668bdd423e17d5436ddb731 --- /dev/null +++ b/interpro_ptm/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2974, + "annotations_size": 4, + "title": "Average number of proteins per term", + "value": 2.25 +} \ No newline at end of file diff --git a/interpro_ptm/paths.json b/interpro_ptm/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..8262031c75c6db2ef496ca14d3ecf71ce7bd96da --- /dev/null +++ b/interpro_ptm/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/interpro_ptm/fragment/C220/C220_val_log2fc"} \ No newline at end of file diff --git a/interpro_ptm/result.tsv b/interpro_ptm/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..3490e23ef0f400c6106567bc8fa9f39f36308c24 --- /dev/null +++ b/interpro_ptm/result.tsv @@ -0,0 +1,2 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +P-type ATPase, phosphorylation site [IPR018303] 0.8174469518356344 2.063733772997012 0.039042965342845 0.1472614799299932 0.07808593068569 5 P35670,P05023,Q9HD20,P16615 4 diff --git a/interpro_ptm/selections.json b/interpro_ptm/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..a87dcf8cb779d3275f1abbd74cde99beec05ad71 --- /dev/null +++ b/interpro_ptm/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["EGF-type aspartate/asparagine hydroxylation site [IPR000152]", "P-type ATPase, phosphorylation site [IPR018303]", "Phosphopantetheine attachment site [IPR006162]", "Translation elongation factor, IF5A, hypusine site [IPR019769]"], "available_proteins": ["ATP13A1", "ATP1A1", "ATP2A2", "ATP2B1", "ATP7B", "EIF5A", "FASN", "LRP1", "SLIT2"], "leading_proteins": ["ATP13A1", "ATP1A1", "ATP2A2", "ATP7B"]} \ No newline at end of file diff --git a/interpro_repeat/advanced/idx2term.json b/interpro_repeat/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..6dce773863970e13dd9ed6c0019ab4c4e97de280 --- /dev/null +++ b/interpro_repeat/advanced/idx2term.json @@ -0,0 +1 @@ +{"0": "Mitochondrial substrate/solute carrier [IPR018108]"} \ No newline at end of file diff --git a/interpro_repeat/advanced/plot_0.png b/interpro_repeat/advanced/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..4b849db991ff3367a0aca1f491585015d8e734ee --- /dev/null +++ b/interpro_repeat/advanced/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:38b0c506add6488a38f38aa6e2c03a36c311df07b051e1ef79357be251b60c3d +size 177423 diff --git a/interpro_repeat/basic/idx2term.json b/interpro_repeat/basic/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..6dce773863970e13dd9ed6c0019ab4c4e97de280 --- /dev/null +++ b/interpro_repeat/basic/idx2term.json @@ -0,0 +1 @@ +{"0": "Mitochondrial substrate/solute carrier [IPR018108]"} \ No newline at end of file diff --git a/interpro_repeat/basic/plot_0.png b/interpro_repeat/basic/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..d1c2b79d39d862c219e321e118115c3ad9631562 --- /dev/null +++ b/interpro_repeat/basic/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:47ff6e7bf41968b78a9489bae394c4df27e21c62136e7a20b93fdbe6020c7a0b +size 145859 diff --git a/interpro_repeat/consensus.joblib b/interpro_repeat/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..28da1dbba88b154c238b7bf7d6937c4796708500 --- /dev/null +++ b/interpro_repeat/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:6ec999519f00861714104fdf808dfd371db26a954c5c60b498a4720fee0fe582 +size 72954 diff --git a/interpro_repeat/df_merge.tsv b/interpro_repeat/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..0605835dc6dd1494909da5502131fcf7b361086b --- /dev/null +++ b/interpro_repeat/df_merge.tsv @@ -0,0 +1,2 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Mitochondrial substrate/solute carrier [IPR018108] 22 23 3.857387164934564 0.0001146055556109 9.148058252427184 20.71359223300971 2.0411027534642088 0.1411881998864352 5.368907349966936 1.8276489510009888 1.309103123363054 0.2428184236965967 2.7244366583104737e-12 0.0007818203448131 0.0004434091565531 1.2429151463024507e-08 4.266527055835198e-12 diff --git a/interpro_repeat/metrics.json b/interpro_repeat/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..d85c4a447fd1628b5cbe103e283ab73a94037507 --- /dev/null +++ b/interpro_repeat/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2974, + "annotations_size": 73, + "title": "Average number of proteins per term", + "value": 5.465753424657534 +} \ No newline at end of file diff --git a/interpro_repeat/paths.json b/interpro_repeat/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..baf538cc6f1482195a42df664424f44c848c1145 --- /dev/null +++ b/interpro_repeat/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/interpro_repeat/fragment/C220/C220_val_log2fc"} \ No newline at end of file diff --git a/interpro_repeat/result.tsv b/interpro_repeat/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..e4d30820023ef5998629943d44b7aaee45399b12 --- /dev/null +++ b/interpro_repeat/result.tsv @@ -0,0 +1,7 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Mitochondrial substrate/solute carrier [IPR018108] 0.7587258556421699 3.857387164934564 0.0001146055556109 0.0083317817035466 0.0083662055595984 23 Q9HC21,Q9UJS0,Q70HW3,Q9UBX3,P05141,O43772,Q9NZJ7,Q9H2D1,Q00325,Q9H936,Q9Y6C9,Q02978,Q9BQT8,P12236,Q9Y619,O75746,Q9BSK2,Q86VD7,Q6NUK1,O43808,P12235,P53007 22 +Atypical Arm repeat [IPR032413] 0.745869765291504 1.4642024687297417 0.1431386359039252 0.9999873389143344 0.2985462977424727 4 O00505 1 +HEAT repeat [IPR000357] 0.559681277040758 1.1417293950359195 0.2535665183312121 0.9999999994650032 0.4304733915855461 8 P30153,Q6PJG6,P30154 3 +Sel1-like repeat [IPR006597] 0.6897711978465793 0.6721843962587156 0.5014663133652115 1.0 0.7177851152090282 2 Q9UBV2 1 +Pentatricopeptide repeat [IPR002885] 0.5207001009760834 0.1685450043599342 0.8661545416779513 1.0 0.9437206200371708 3 Q92552,Q96EY7 2 +Kinesin light chain repeat [IPR015792] 0.4160215415684885 0.0140671851957086 0.9887763802852496 1.0 1.0 3 Q9H0B6,Q9NSK0 2 diff --git a/interpro_repeat/selections.json b/interpro_repeat/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..a6fa5f95a1ea4db28efb15b447180e54453f7bb4 --- /dev/null +++ b/interpro_repeat/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["Ankyrin repeat [IPR002110]", "Annexin repeat [IPR018502]", "Armadillo [IPR000225]", "Atypical Arm repeat [IPR032413]", "BIR repeat [IPR001370]", "Calponin repeat [IPR000557]", "Cation-independent mannose-6-phosphate receptor repeat [IPR000479]", "Chromosome region maintenance repeat [IPR041123]", "Clathrin, heavy chain, propeller repeat [IPR022365]", "Clathrin, heavy chain/VPS, 7-fold repeat [IPR000547]", "Collagen triple helix repeat [IPR008160]", "Cysteine-rich Golgi apparatus protein 1 repeat [IPR001893]", "Cysteine-rich Golgi apparatus protein 1 repeat, eukaryote [IPR017873]", "Exportin-1, repeat 2 [IPR041235]", "Exportin-1, repeat 3 [IPR040485]", "Filamin/ABP280 repeat [IPR001298]", "Filamin/ABP280 repeat-like [IPR017868]", "Fis1, C-terminal tetratricopeptide repeat [IPR028061]", "Fis1, N-terminal tetratricopeptide repeat [IPR028058]", "G-protein beta WD-40 repeat [IPR020472]", "GTF2I-like repeat [IPR004212]", "HAT (Half-A-TPR) repeat [IPR003107]", "HEAT repeat [IPR000357]", "HEAT, type 2 [IPR021133]", "HUWE1/Rev1, ubiquitin binding region [IPR025527]", "Hexapeptide repeat [IPR001451]", "Hs1/Cortactin [IPR003134]", "Importin repeat 4 [IPR041653]", "Importin repeat 6 [IPR041389]", "Importin repeat [IPR040928]", "KI67R [IPR012568]", "Kelch repeat type 1 [IPR006652]", "Kelch repeat type 2 [IPR011498]", "Kinesin light chain repeat [IPR015792]", "LDLR class B repeat [IPR000033]", "Leucine rich repeat 4 [IPR025875]", "Leucine-rich repeat [IPR001611]", "Leucine-rich repeat, cysteine-containing subtype [IPR006553]", "Leucine-rich repeat, typical subtype [IPR003591]", "Low-density lipoprotein (LDL) receptor class A repeat [IPR002172]", "Mbt repeat [IPR004092]", "Microtubule associated protein, tubulin-binding repeat [IPR001084]", "Mitochondrial substrate/solute carrier [IPR018108]", "Nebulin repeat [IPR000900]", "Neuraxin/MAP1B repeat [IPR000102]", "P120R repeat [IPR012586]", "PBS lyase HEAT-like repeat [IPR004155]", "PFTB repeat [IPR001330]", "PQ-loop repeat [IPR006603]", "Paired amphipathic helix [IPR003822]", "Pentatricopeptide repeat [IPR002885]", "Plectin repeat [IPR001101]", "Proteasome/cyclosome repeat [IPR002015]", "Protein of unknown function DM15 [IPR006607]", "Protein prenyltransferase, alpha subunit [IPR002088]", "Proteinase inhibitor I27, calpastatin [IPR001259]", "Pumilio RNA-binding repeat [IPR001313]", "Putative TPR-like repeat [IPR031545]", "Pyrrolo-quinoline quinone repeat [IPR002372]", "RNA helicase p68 repeat [IPR012587]", "RNA polymerase II, heptapeptide repeat, eukaryotic [IPR000684]", "Regulator of chromosome condensation, RCC1 [IPR000408]", "Ribonuclease inhibitor, leucine rich repeat cap [IPR041302]", "Sel1-like repeat [IPR006597]", "Spectrin repeat [IPR002017]", "Spectrin/alpha-actinin [IPR018159]", "Tetratricopeptide repeat 1 [IPR001440]", "Tetratricopeptide repeat 2 [IPR013105]", "Tetratricopeptide repeat [IPR019734]", "Vesicle tethering protein p115, armadillo tether-repeat [IPR041209]", "WD40 repeat [IPR001680]", "Wolframin, Sel1-like repeat [IPR045458]", "Zinc finger, C2H2C-type [IPR002515]"], "available_proteins": ["AAAS", "AAMP", "ACTN1", "ACTN4", "AIP", "ANAPC5", "ANAPC7", "ANKFY1", "ANKHD1", "ANKRD17", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA3", "ANXA4", "ANXA6", "ANXA7", "AP1B1", "AP2B1", "ARMC6", "ARMC8", "ARMCX3", "ARPC1A", "ASPH", "BIRC6", "BOP1", "BRAT1", "BUB3", "CAST", "CD320", "CDC16", "CDC20", "CDC23", "CDC27", "CDC40", "CHAF1B", "CKAP5", "CLASP1", "CLPB", "CLTC", "CNN3", "CNOT10", "COA7", "COLEC12", "COPA", "COPB2", "CORO1B", "CORO1C", "CORO7", "CRNKL1", "CSTF3", "CTNNB1", "CTNND1", "CTR9", "CTTN", "DCAF13", "DCAF7", "DDX5", "DNAAF5", "DNAJC3", "DNAJC7", "DOHH", "DSP", "DST", "DYNC1I2", "EDC4", "EIF2B5", "EIF3I", "ELP2", "EMC1", "EMC2", "EML4", "EPPK1", "FIS1", "FKBP4", "FKBP5", "FKBP8", "FLII", "FLNA", "FLNB", "FLNC", "FNTA", "FNTB", "GCN1", "GEMIN5", "GLG1", "GLS", "GMPPB", "GRWD1", "GTF2I", "GTF3C2", "GTF3C3", "HCFC1", "HECTD1", "HUWE1", "IGF2R", "ILK", "IPO4", "IPO5", "JUP", "KAT7", "KDELC2", "KDM2A", "KIAA1468", "KLC1", "KLC2", "KLC4", "KPNA1", "KPNA2", "KPNA3", "KPNA6", "KPNB1", "LARP1", "LASP1", "LRBA", "LRP1", "LRPPRC", "LRRC1", "LRRC40", "LRRC47", "LRRC59", "LRWD1", "MACF1", "MAP1B", "MAP4", "MAU2", "MKI67", "MPDU1", "MRPS27", "MTCH1", "MTCH2", "MTPN", "NAA15", "NASP", "NEK9", "NLE1", "NLRX1", "NOL10", "NOP2", "NOP9", "NUP214", "NUP37", "NUP43", "NXF1", "OGT", "P4HA1", "PAFAH1B1", "PAK1IP1", "PDCD11", "PEX5", "PHIP", "PIK3R4", "PLAA", "PLEC", "PLRG1", "POLR2A", "PPID", "PPP1R12A", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP4R1", "PPP5C", "PPWD1", "PREB", "PRKCSH", "PRMT9", "PRPF19", "PRPF39", "PRPF4", "PRPF6", "PSMD1", "PSMD10", "PSMD2", "PTCD3", "PUM1", "PUM3", "PWP1", "PWP2", "RABEPK", "RACK1", "RAE1", "RAI14", "RANBP2", "RANBP6", "RANGAP1", "RBBP5", "RBBP7", "RCC1", "RCC2", "RNH1", "RPAP3", "RPTOR", "RRP9", "RSU1", "SART3", "SCML2", "SCRIB", "SEC31A", "SEH1L", "SEL1L", "SGTA", "SIN3A", "SKP2", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A17", "SLC25A19", "SLC25A20", "SLC25A21", "SLC25A22", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A33", "SLC25A4", "SLC25A40", "SLC25A42", "SLC25A5", "SLC25A6", "SLIT2", "SMU1", "SNRNP40", "SNRPA1", "SPTAN1", "SPTBN1", "SPTBN2", "SRP72", "STIP1", "STRAP", "STRN", "SUGT1", "SYNE2", "TAGLN2", "TBL2", "TBL3", "TEX10", "THOC3", "THOC6", "TMTC3", "TOMM34", "TOMM70", "TTC1", "TTC19", "TTC26", "TTC37", "TTC4", "UNC45A", "USO1", "UTP15", "UTP18", "UTP4", "UTP6", "UTRN", "VPS18", "WDHD1", "WDR1", "WDR11", "WDR12", "WDR18", "WDR26", "WDR3", "WDR34", "WDR36", "WDR41", "WDR43", "WDR46", "WDR48", "WDR5", "WDR6", "WDR61", "WDR70", "WDR75", "WDR77", "WDR82", "WFS1", "WIPI2", "XAB2", "XPO1", "YTHDC2", "ZDHHC13"], "leading_proteins": ["BRAT1", "KLC2", "KLC4", "KPNA3", "MRPS27", "MTCH1", "MTCH2", "PPP2R1A", "PPP2R1B", "PTCD3", "SEL1L", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A17", "SLC25A19", "SLC25A20", "SLC25A21", "SLC25A22", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A33", "SLC25A4", "SLC25A42", "SLC25A5", "SLC25A6"]} \ No newline at end of file diff --git a/msigdb_gobp/advanced/idx2term.json b/msigdb_gobp/advanced/idx2term.json new file mode 100644 index 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transport", "5": "Mitochondrial membrane organization", "6": "Sphingolipid metabolic process", "7": "Membrane lipid metabolic process", "8": "Endoplasmic reticulum organization", "9": "Mitochondrial respiratory chain complex assembly", "10": "Protein localization to mitochondrion", "11": "Carboxylic acid transport", "12": "Inner mitochondrial membrane organization", "13": "Organic acid transmembrane transport", "14": "Glycoprotein metabolic process", "15": "Protein insertion into membrane", "16": "Organophosphate ester transport", "17": "Glycoprotein biosynthetic process", "18": "Membrane lipid biosynthetic process", "19": "Protein transmembrane transport", "20": "Sphingolipid biosynthetic process", "21": "Ceramide metabolic process", "22": "Carbohydrate derivative transport", "23": "Ion transmembrane transport", "24": "Transmembrane transport", "25": "Oxidative phosphorylation", "26": "Inorganic anion transport", "27": "Hormone metabolic process", "28": "Proton transmembrane 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0000000000000000000000000000000000000000..9a0d01d7e1cdf45b35f480060faf742985eb7b19 --- /dev/null +++ b/msigdb_gobp/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:66c3a03ef220c4767a675bfa1bbfd7fff85ff0f622561ebfcc55aca32cc21d4a +size 439117 diff --git a/msigdb_gobp/df_merge.tsv b/msigdb_gobp/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..7a13af02048dd5109debe75c56bf5fe88cb51215 --- /dev/null +++ b/msigdb_gobp/df_merge.tsv @@ -0,0 +1,175 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Anion transport 49 68 5.392074423664214 6.964890790114039e-08 26.953883495145632 69.53155339805825 1.854216838065017 0.2425457725148559 12.138973160217668 8.434296289414672 2.014686633079497 0.3448588040224388 1.1616489858605032e-12 0.0003660463043171 0.0006188538425275 5.32051017318469e-08 2.772829658019317e-12 +Mitochondrial transmembrane transport 35 54 4.766444139643943 1.8750568417935651e-06 19.070388349514563 50.63834951456311 1.9310146760091371 0.188342667216329 9.760351579527285 3.939196260509299 1.9786128158557912 0.3017981993827387 3.3063828705597853e-14 2.947739650573756e-06 1.527728758758338e-05 1.1323450018501472e-10 7.039259840771936e-15 +Organic anion transport 33 43 4.495272893642169 6.948078066892904e-06 18.575242718446603 46.57281553398058 1.6158560948583975 0.2692356013040078 9.46386426798458 5.9518324529926545 1.7470285445738305 0.3371920110610632 6.275360175037074e-07 0.0316897967394195 0.048287555812517 3.6721982640872496e-05 1.0298595595859285e-06 +Anion transmembrane transport 32 41 4.464903496363753 8.010484962017728e-06 18.02912621359223 42.29854368932039 1.9137296804814252 0.1915609440243116 8.771596162415214 5.032004157423188 1.8922368499585025 0.2935375719655638 5.854621725942802e-09 0.0019982551464922 0.0006744002481248 2.322804771960576e-06 1.003353099717741e-08 +Mitochondrial transport 40 86 4.354192850903765 1.3355809430626309e-05 26.76456310679612 83.42233009708738 1.9353944346565397 0.260698067067068 11.29934298946582 6.8259418360610375 1.9296757414965091 0.3685496297416806 1.8010049377049818e-13 1.220543312426503e-06 5.434435692649171e-07 9.672998160415676e-08 7.540211585888795e-14 +Mitochondrial membrane organization 27 51 4.2679864320777785 1.972453214893477e-05 16.983009708737864 46.91019417475728 1.283632855732258 0.3380738792929293 7.413069190635445 4.027718639381892 1.6948461264793506 0.367302285357348 2.624506516701529e-10 0.0775893010402436 0.0002951956690697 3.863819099097614e-07 4.596827393429238e-10 +Sphingolipid metabolic process 24 32 4.2475790000524185 2.1609297727209764e-05 12.631067961165048 29.174757281553397 1.3566630100256978 0.1614907042591146 4.986857078326301 3.461093559903884 2.232073980338918 0.2503191978902473 1.1116451037856418e-09 0.0102936075696032 0.0019776270278221 3.007435013185771e-07 1.891168768334001e-09 +Membrane lipid metabolic process 29 41 4.229166340803538 2.3455887416590212e-05 15.813106796116504 37.71116504854369 1.423850539998867 0.1808469841706369 6.252884620395072 4.742042041181393 2.289538519382486 0.2724480316274368 8.012983066827225e-10 0.0197758267942588 0.005659652817264 8.84903201627466e-07 1.4478149981186219e-09 +Endoplasmic reticulum organization 18 43 4.202516755546967 2.6396370311765335e-05 14.91747572815534 43.67718446601942 1.1418424810127707 0.3725584991544436 6.208589840117394 4.768440325801463 1.6823827875834556 0.3705219831566139 9.119396495872203e-10 0.3075216202298709 0.0007612924156222 0.0021134706523073 1.4919475968405364e-09 +Mitochondrial respiratory chain complex assembly 26 40 4.173636039241944 2.997765227763516e-05 14.427184466019416 38.300970873786405 1.6683402305651691 0.229838901803248 5.648441561419256 5.588363345618 1.6629328950455762 0.3088219725228932 5.86649752295151e-10 0.0009257347283437 2.391679760144043e-05 2.602953228173561e-08 1.0021035474386755e-09 +Protein localization to mitochondrion 28 61 4.143732042461309 3.416989831239725e-05 18.37621359223301 58.6747572815534 1.743973973786015 0.2835887708870952 7.329731795051445 5.553888141183353 1.6030721833013164 0.3628376459321563 7.949256472933839e-11 0.001748605497394 7.225121220356148e-05 4.8680044939330585e-05 2.315910567550452e-11 +Carboxylic acid transport 23 31 4.0887952034977575 4.336194661735959e-05 12.351941747572816 33.69417475728155 1.517249458545343 0.2522623764771551 6.23371050940395 4.11174791553619 1.419876490432768 0.3135855212793009 0.0010181192117475 0.0138765381826926 0.0177198518564191 0.0034558464860743 0.0013304375239164 +Inner mitochondrial membrane organization 17 23 4.002196797729795 6.275706412939286e-05 9.985436893203884 20.800970873786408 1.138268089020681 0.2873707765098114 4.6289277788641146 2.4012939531921327 1.609232985153232 0.3229583948801056 3.614163829814518e-10 1.0 0.0480988323617951 2.180557064549601e-05 5.321107736099699e-10 +Organic acid transmembrane transport 24 29 3.9348999338797 8.323136630439265e-05 12.37621359223301 29.983009708737864 1.9038035525846064 0.1759244630123113 6.520447095353999 3.550222565141749 1.416714921004232 0.2641413901650407 0.001026282134835 0.0564048148733258 0.0405305960068218 0.0028353036441765 0.0013025791117905 +Glycoprotein metabolic process 23 62 3.908124389950682 9.301541616779652e-05 18.59223300970874 59.577669902912625 0.8707431654759812 0.409720724299967 7.543964208858723 9.989377193127202 1.488085349392555 0.3835029669336279 0.0001118434791395 0.6674460421157596 0.6376801734805604 0.0028473074171923 0.0001751026591922 +Protein insertion into membrane 18 29 3.881352199195381 0.0001038772756687 9.861650485436892 27.67718446601942 1.4180388387951812 0.2751856944202687 4.426616888970974 3.3195747527036987 1.508549988584809 0.3318307488597651 5.045069247113035e-10 0.2183067054048652 0.0001167245250019 0.0001848356829715 7.764045804423406e-10 +Organophosphate ester transport 18 27 3.88001334762788 0.0001044507327336 10.29126213592233 27.364077669902912 1.4948680330369015 0.1889391065154625 4.84293313185659 4.31957284765524 1.6451867819665518 0.2532208690981375 4.5985765871490324e-07 0.3175327074700926 0.5314369287659462 0.0005474268861588 6.817676048084553e-07 +Glycoprotein biosynthetic process 21 53 3.741006992226312 0.0001832844210245 16.72087378640777 51.87378640776699 1.042113998842759 0.381483262234126 6.756316800759528 8.908847583990125 1.5232206853916193 0.3819786061588057 5.9689719193578095e-05 0.603038217660401 0.5427945879382776 0.001897595178002 9.210568817474228e-05 +Membrane lipid biosynthetic process 18 26 3.710767201843728 0.0002066320627367 8.866504854368932 23.050970873786408 1.3229385051208649 0.2431293012321725 4.229937732502716 3.4850337476777224 1.635527795490498 0.2996124846932806 1.9350829454655408e-05 0.3274019772455256 0.0431051081708364 0.0001335232689129 2.6852320995274902e-05 +Protein transmembrane transport 19 28 3.66687932806498 0.0002455285894951 8.992718446601941 25.191747572815533 1.6893060623430327 0.189108476986505 4.473486660459625 2.7693940759543416 1.4682653164365471 0.2783169275392022 2.2870365785804023e-05 0.0020640692536444 0.0015776300418353 0.0015168102247799 5.03043977835364e-06 +Sphingolipid biosynthetic process 14 19 3.640304979944699 0.0002723152983508 6.543689320388349 16.33252427184466 1.3108583596388097 0.2293036031089034 3.2058099533310203 2.4273143169149307 1.5209865792019848 0.2861850290041513 1.2118964531809568e-05 0.2480154974279715 0.0184792322064663 6.992992578598031e-05 1.6287224658028937e-05 +Ceramide metabolic process 16 22 3.6289970093195207 0.0002845245365963 8.191747572815533 19.060679611650485 1.0632949889077032 0.1865092544415649 3.2982239784478966 2.5917545738626013 1.8901201919357584 0.2494992632187684 1.3367494726033038e-06 0.2406936845278361 0.0168596271371444 5.428289418428127e-05 1.8578674503347007e-06 +Carbohydrate derivative transport 15 17 3.622175026115348 0.000292136344498 7.924757281553398 17.024271844660195 1.3665639952580566 0.1869571280171947 4.210097511648942 2.624454303682939 1.5541767319140831 0.2467993156006303 9.686810287363574e-09 0.1991580424676108 0.356411341728891 9.451607509261606e-05 1.4092509332528557e-08 +Ion transmembrane transport 88 152 3.5704497102660744 0.0003563688712115 47.09466019417476 154.11893203883494 1.555073205784263 0.3634279635891347 19.61122797656 15.97124025754773 1.9676287128633565 0.411597796705808 1.0745316804423468e-10 8.07603052041246e-06 2.4648530187413285e-05 9.315144651660969e-09 3.253798690485971e-10 +Transmembrane transport 127 212 3.5063733890052378 0.0004542574916968 67.45631067961165 211.1359223300971 1.8122664376950308 0.3598356673827246 27.267027885156203 22.354947126810902 2.251277763144546 0.4188333713481413 4.042284587191496e-15 1.928476944432315e-07 2.224289522804872e-06 1.5038453886864883e-10 2.120412483284478e-15 +Oxidative phosphorylation 31 58 3.504031411858018 0.0004582712983416 18.140776699029125 60.61893203883495 0.8137621380364766 0.3661293054253088 7.750013302753429 5.582386553809936 1.7413544544034578 0.3762713520958283 1.859893065907115e-06 0.0002518558292813 0.0001333365777289 2.4429488033516573e-05 2.872058632003573e-06 +Inorganic anion transport 15 26 3.4928483577475995 0.0004778978099131 9.900485436893204 25.351941747572816 1.3590123122148194 0.2025490755989976 4.608697956226863 4.352203003870329 1.5972877171217004 0.2769639658120273 6.244768894458185e-08 0.0003235415753736 0.0004879890681661 0.0002150367163731 9.382070529230001e-08 +Hormone metabolic process 17 32 3.477493839987879 0.0005061246801982 8.95631067961165 28.65776699029126 1.130508313948193 0.2963365150575847 3.9674689274001818 2.5345884681715156 1.346801337886388 0.3240077568826507 1.7276648920930742e-06 0.078986772223975 0.0649154719665051 0.0081760274425246 2.5803976056801717e-06 +Proton transmembrane transport 25 43 3.467386989189724 0.0005255446763399 14.28640776699029 43.01699029126213 0.7821394801431882 0.3918912894345224 6.076814900000799 3.1076483585332 1.5710697941383835 0.3739424994204808 9.25087131256836e-05 0.0102936075696032 0.0122290647268822 7.416465886785485e-05 0.0001263913590946 +Nadh dehydrogenase complex assembly 12 29 3.443230994663166 0.0005748081212237 9.266990291262136 26.96359223300971 1.1245271541492263 0.3013677937017552 4.122702675359976 4.029157649894909 1.4460543016521823 0.3224564676521605 1.3367494726033038e-06 0.0305319028295214 0.002067436699404 6.862705248072223e-06 1.8578674503347007e-06 +Protein targeting to mitochondrion 23 47 3.420464388320178 0.0006251431991175 14.980582524271844 46.067961165048544 1.7767024064550243 0.249920045184344 6.494927942714517 4.708517660750424 1.5433015545903224 0.3384144763122346 1.270849191302886e-08 0.0008162643340865 0.0014759891253618 0.004831216960231 3.354303833235464e-09 +Organic acid transport 29 44 3.415681409695769 0.0006362263546235 16.199029126213592 46.1626213592233 1.6912598339530378 0.23494744574913 7.685833584742487 5.405881453891157 1.4084922190667013 0.315570201131532 0.0103394539266061 0.1403881914917208 0.141777722869203 0.0445840994270362 0.0129865502203986 +Intracellular protein transmembrane transport 16 25 3.415135446915693 0.0006375030209126 7.233009708737864 21.9004854368932 1.450039081018812 0.2247265328975946 3.8281123729210935 2.4627910122818513 1.3220665029303609 0.2876555154826584 2.875022417974631e-05 0.0196403757049561 0.0088720794008613 0.0040714376200731 5.640751162886056e-06 +Establishment of protein localization to membrane 35 90 3.4128336632765723 0.0006429117022894 23.133495145631063 87.3616504854369 1.231448880072231 0.4195243824117992 8.397245527204214 9.510228790351464 1.3947369206386535 0.4065372973031916 1.899856737513593e-07 0.6294205244747506 0.003253953987006 0.0011445721743307 9.910793754416589e-08 +Inorganic ion transmembrane transport 56 110 3.4093518319701186 0.0006511743974513 32.300970873786405 111.99514563106796 0.9881513097876132 0.4268253140664947 13.185263141323642 11.586314982845243 1.7161030277526947 0.4113555760685328 2.731643210383185e-06 0.0011466369379109 0.0051646636336174 0.000182860617923 5.348465587850397e-06 +Cation transmembrane transport 61 116 3.403173606511761 0.0006660794316322 33.43446601941748 118.4004854368932 1.1701058025505957 0.4085228823574113 14.425169362008605 12.553856783980793 1.6663185381795875 0.4066910074955585 8.437769470363434e-06 0.0019190396233932 0.0090934887735964 0.0002209835409643 1.6324176457172175e-05 +Lytic vacuole organization 9 24 3.299102057250115 0.0009699464088623 8.677184466019417 23.79368932038835 1.067589638534915 0.1668002350701783 2.8744208086829883 3.077266940940983 2.0111064761459874 0.2496786569477077 0.0003659277272577 0.0001883783937456 0.0024974565689748 0.0005144645132141 0.0004619557442503 +Glycosylation 16 47 3.2479395680863465 0.0011624395679317 13.33495145631068 45.42718446601942 0.831363055351092 0.4028474919440285 5.5712021107485015 7.578523489860055 1.3433056638769032 0.3649215649501745 0.0012469754035699 0.1826627820387037 0.20003379484876 0.0016416916373979 0.0017110642001382 +Nucleotide transport 12 13 3.2297771816919725 0.0012388672795629 6.189320388349515 13.405339805825244 1.3859091987706234 0.2148450774807873 3.399469193898354 2.266957807297256 1.34942986946681 0.2785977875693559 7.167595170252923e-09 0.1178616319260966 0.2202973788945578 1.741035453580761e-06 9.74666938500055e-09 +Metal ion homeostasis 35 77 3.224935061076493 0.0012600124625792 22.37864077669903 79.5 0.7762327689006491 0.4501210966631583 8.485414676383348 8.298876985671072 1.3957415688189287 0.3857448193070677 0.0004566426624169 0.1320457949075564 0.458986523229727 0.0229663959282448 0.0007021737612565 +Establishment of protein localization to mitochondrial membrane 11 20 3.1563690284747383 0.001597466109525 5.572815533980583 16.524271844660195 1.1986544459127668 0.291784793504827 2.8501471321161915 2.5441524813639957 1.2232399066733852 0.3232066755573589 1.6048298287609685e-07 0.1221118561195742 0.0001142112625336 0.0003804824615668 2.112635157831036e-07 +Electron transport chain 25 66 3.0616641989143054 0.0022011023079968 19.550970873786408 67.77184466019418 0.3712062453977176 0.4872800905659868 8.486701420407794 5.37626783377928 1.3790913022045077 0.3735693075609537 2.3229051424906308e-06 0.0253511637379553 0.0084047560376835 6.845334262314592e-05 3.637637446540144e-06 +Endoplasmic reticulum tubular network organization 6 11 3.046243308759965 0.0023172024087798 4.150485436893204 10.555825242718448 0.8961707031484618 0.3171343629503343 2.1669796342432037 1.8339543060404635 1.2935176897309475 0.3199619326088047 5.421083652472187e-06 0.0786913117950012 0.0111011801010317 0.0070197321203344 6.586690043237225e-06 +Ion transport 96 198 3.0302368672239064 0.0024436201224495 59.95631067961165 203.33495145631068 1.28794420214731 0.4483240343684334 22.7179419701651 20.293344878478432 1.852388371824549 0.4292871393353351 7.098525787309259e-11 3.252372574888117e-05 8.622488239052364e-05 9.415343326554892e-08 2.610490058615702e-10 +Mitochondrion organization 90 189 3.019384942437384 0.002532884801023 56.45873786407767 188.26941747572815 1.5905300936136977 0.4100157441778524 20.15716756472138 18.40319032732565 2.034523716094369 0.4327537677377048 4.0705084443448176e-17 8.367828938374419e-08 2.0350328307153892e-08 4.0794291818600576e-11 4.5749858815735026e-17 +Endoplasmic reticulum to golgi vesicle mediated transport 25 64 3.006571846308637 0.0026421160914551 17.32766990291262 65.39077669902913 0.808881464821498 0.4942452999677598 7.539018980743236 6.620812461410292 1.284359804176963 0.3933269611423161 0.0002414416676261 0.1054077938723316 0.0964752293748221 0.1380817394363983 0.0003310703948715 +Ceramide biosynthetic process 9 12 2.977768974010334 0.0029035475252179 4.033980582524272 10.24757281553398 1.048715387316577 0.2344614502118888 2.237979905601341 2.0281678881596505 1.4071730245015133 0.2685344998940062 0.0009122015439812 0.1553991536419083 0.004381787725469 0.0001530781343508 0.0010842824506653 +Amino acid transport 12 17 2.975763329897704 0.0029226031466162 7.771844660194175 19.75 0.8410032854505353 0.3449280742441291 4.117377746800764 3.003739578643708 1.287399790463736 0.3206698223659758 0.2107036957602921 1.0 0.4840762718710899 0.4902724480503764 0.2279338536197104 +Regulation of hormone levels 29 67 2.921109674838118 0.003487870199704 15.682038834951456 62.25485436893204 0.7754141622249116 0.4638741971732045 6.630568201753413 6.49574922456989 1.111399769110166 0.3798141702267368 0.0004124428848295 0.2801791252263636 0.1519417330064447 0.034119627885826 0.0006141365781015 +Dicarboxylic acid transport 11 14 2.899389196956529 0.0037389046941977 5.718446601941747 16.097087378640776 1.1205667041867788 0.2998586575349944 3.584398436287638 2.226340822602054 1.0973546365412417 0.2986830136605488 0.0422918765132633 0.0172375696548913 0.0603249601752956 0.0171039247471448 0.0470090097614683 +Amino acid transmembrane transport 10 13 2.8924314729048906 0.0038227256384626 6.213592233009709 14.228155339805824 0.7890307267204019 0.3318923540291705 3.493823914060917 1.9561661273054285 1.3497309258640615 0.3227865040448734 0.1689031787049104 1.0 0.36256189343107 0.3072275582187334 0.181678229282176 +Protein transmembrane import into intracellular organelle 10 15 2.8777499139854954 0.0040052251975093 4.951456310679611 13.45631067961165 1.503963012554726 0.1758225015375162 2.735521961789203 1.4944992929031071 1.2360761671845495 0.245991671368161 4.5096672089256e-05 0.0090330503435184 0.032784445092202 0.0334599986224988 6.539043847748048e-06 +Respiratory electron transport chain 22 49 2.877257257707035 0.0040114841134935 15.4126213592233 50.33495145631068 0.497076868891423 0.4388579749555677 7.129498131980449 4.223655269147207 1.4894225458303931 0.3736358875877055 1.4868870317051483e-06 0.0108990791164893 0.0021696295294656 8.877228730914583e-05 2.223725002187074e-06 +Cytochrome complex assembly 6 11 2.8499616699656034 0.0043724498053723 5.339805825242719 11.616504854368932 1.5489281771301031 0.1834582376033618 2.45860248431673 2.439266047793512 1.3189185418401956 0.2620853228235733 0.000759371118072 0.0115082778780227 0.0002868050489301 1.2107128442915264e-05 0.0009037066514027 +Endoplasmic reticulum membrane organization 6 10 2.8499463606434694 0.0043726602677511 3.5679611650485437 8.12621359223301 0.656874598832497 0.271683145803182 1.813579499342004 1.2879547393790816 1.532817064292788 0.2945772195616556 5.620054649569796e-07 1.0 0.0065261066260236 0.0031665778749487 6.862396837091624e-07 +Endoplasmic reticulum unfolded protein response 6 20 2.846143660771685 0.0044252225779413 5.922330097087379 20.817961165048544 0.3028076268112233 0.5117002472852509 2.747246884507101 1.9665572199818449 1.041467084382159 0.3322997623752832 0.0113506300264735 1.0 1.0 0.0388428633787512 0.0131933122365141 +Monovalent inorganic cation homeostasis 15 28 2.833838421733565 0.0045992580351537 9.014563106796116 27.87378640776699 1.1567920478867002 0.2845186374336156 4.051822262152646 3.607380814764068 1.4117439861533438 0.3149022278800241 0.0184703272925716 0.0051240399378157 0.005075346294965 0.0950757237496321 0.0216262489604648 +Purine nucleotide transport 9 10 2.823625704440251 0.0047483801523804 4.970873786407767 10.817961165048544 0.961055494000064 0.2880106547862709 2.8308505383502496 1.988649275322177 1.3314072021441097 0.3042395363852717 1.4585697686775958e-06 1.0 1.0 8.369401706233654e-05 1.820886534068759e-06 +Regulation of mitochondrion organization 13 44 2.8025430579936588 0.0050701447925975 12.08980582524272 45.08252427184466 0.8217268052205459 0.4563186211764868 4.409741308614158 5.146210353910189 1.120993905462196 0.3778427085178187 0.0005464039623734 0.0993430224952972 0.0889933963058261 0.0163896478998186 0.0007304458868176 +Vacuole organization 19 53 2.7872611430082403 0.0053155624373195 14.220873786407768 51.74514563106796 0.8524122478550634 0.3147425083910056 5.370022076358251 7.439112114793103 1.7567175511320523 0.3563110134355993 0.0536476525796727 0.0064011041353566 0.0601718520481821 0.0759941918050065 0.0640928394898164 +Membrane lipid catabolic process 8 12 2.758760236990316 0.0058021087315407 5.854368932038835 11.361650485436892 0.500872843713425 0.1363587272813367 1.9603237645724247 0.9867004907377388 2.113024793917032 0.2289617793743788 9.120885558043578e-08 0.0040679264544396 0.0008461128461095 8.369401706233654e-05 1.1744820075079824e-07 +Cellular monovalent inorganic cation homeostasis 14 25 2.7441070286064595 0.0060675751910117 8.191747572815533 25.12378640776699 1.1978511848260835 0.2636491484517694 3.558748260132903 2.9783551257949803 1.4212259473978417 0.3021468238591936 0.0065142513791002 0.003086924646434 0.0026534702472046 0.056490666234841 0.0077348875089654 +Positive regulation of mitochondrion organization 6 22 2.740154243878843 0.0061410357230016 6.235436893203883 22.393203883495147 0.6669540243221574 0.4355223453199826 2.7589935116766484 2.962672702300372 1.01251720769805 0.3295170825531805 0.0102738826383675 0.0266825716175236 0.0138699265420804 0.0082073559004823 0.0119555617216972 +Steroid metabolic process 21 68 2.733457635498471 0.0062673185264603 17.82766990291262 66.9247572815534 0.9974586731388552 0.3270410156332073 6.090491666967852 5.93996409793671 1.7133199907504504 0.3720334828404655 2.5026134126519726e-06 0.1723298875515411 0.0164256976668591 0.0003339067016849 4.041256682515704e-06 +Protein targeting 51 113 2.7331462694948323 0.0062732466514507 30.48543689320388 111.54126213592232 1.595466660966077 0.3336055854889273 10.683999539888966 11.70327920021055 1.673091584234216 0.3988264387816677 4.349993430365772e-08 0.0068519784881021 0.0026411670929136 0.0026357510406001 7.591676066251816e-09 +Liposaccharide metabolic process 12 18 2.723389827192621 0.0064615763280218 7.393203883495145 16.839805825242717 0.7162233803449398 0.1804705798886219 2.8837934205508033 2.921890590438037 1.8930166841377585 0.2403675114219934 0.0002749804282735 0.2443632781182481 0.105191413992555 0.0484766154729776 0.0003480102587118 +Vesicle docking 9 16 2.7186048963791323 0.0065557865114236 5.046116504854369 16.300970873786408 0.2955335573812314 0.5566344803804099 2.726231700974349 2.3037957343391864 0.8857805503827542 0.3078464388536641 0.0543854529532901 1.0 0.3502020618548794 0.2895837506203981 0.060259514575604 +Cation transport 70 149 2.713006822514943 0.006667573380535 40.9247572815534 152.4733009708738 1.0106305648473772 0.4693050539746304 15.98502541638414 15.374508146736815 1.5607432077940149 0.4143686874753333 9.252345394096988e-05 0.0091015487948617 0.0074110088597377 0.000730427307801 0.0001774410076213 +Aerobic respiration 30 83 2.7124242044366933 0.006679305471247 23.075242718446603 86.43446601941747 0.4685851027775424 0.4381258038241513 10.546552774557412 6.275478278783705 1.570513830163352 0.3792860784147517 3.4509238508328165e-06 0.0009492885248983 0.000130803492928 5.378283042080686e-06 5.55018787647823e-06 +Sensory perception of light stimulus 9 14 2.7063550267050807 0.0068026277085577 5.009708737864078 15.96359223300971 0.918103407248628 0.3572194322029593 2.4583724414330383 3.147064390877318 0.9947617981182544 0.3055434177582076 0.0030596152653684 0.2731012734555347 0.0248074025314705 0.0199702538754952 0.0037202796455188 +Protein n linked glycosylation 11 22 2.694584522854438 0.0070476449244116 6.177184466019417 18.78640776699029 0.2004880128160887 0.4683260162783809 3.1676710128395498 3.0254598797887766 1.208633498192774 0.333447209788965 0.0010712730033863 0.2406936845278361 0.1021730546658088 0.0110971224242302 0.0013169402934459 +Cellular ion homeostasis 35 87 2.689400217691353 0.0071580543254812 24.48543689320388 87.34708737864078 0.921352068115914 0.4223079442129951 9.212290310790763 8.933596252465952 1.5207794649628892 0.4002972861975121 0.0007913109644394 0.1430583240174933 0.2617218510121877 0.0133051703969829 0.0012008442931693 +Lipoprotein metabolic process 6 19 2.6868438632605 0.0072130661284963 5.504854368932039 19.114077669902912 1.0723975558987071 0.2794846862458811 2.648039342123219 3.7213756556771336 1.2556798055308762 0.2951644225033464 0.0412578437028739 0.0627750690965546 0.0086609949738754 0.0039874357255632 0.0476532414252585 +Regulation of cellular ph 13 22 2.682403510853332 0.0073095234454811 6.885922330097087 20.844660194174757 1.215766922704761 0.2375185297794358 2.9319293283093293 2.765976649626597 1.4143296516981956 0.2875299337708636 0.0066987890485908 0.0016453439849387 0.0011750725005838 0.0284946927562346 0.0078315793031748 +Regulation of ph 13 22 2.682403510853332 0.0073095234454811 6.890776699029126 20.859223300970875 1.2151699598837196 0.2373503364294603 2.930458126920059 2.7746402510870145 1.4154672965603718 0.2873526492076106 0.0092734634325317 0.0019537982219709 0.0014691652083679 0.0344783823248686 0.0108038870628888 +L amino acid transport 8 11 2.6749719339314084 0.0074735506430962 5.114077669902913 11.91504854368932 0.7755289387861473 0.3283794523692901 2.998235059113201 1.3256494094845783 1.3058948249973923 0.3189923022900864 0.204439302357496 1.0 0.277861461810767 0.1927267877862009 0.2166592364389877 +Transition metal ion transport 7 15 2.6403744882044125 0.0082814461246807 4.70873786407767 14.08980582524272 0.8861898222657586 0.2678437025860737 2.4756329698054333 2.718007722894407 1.3738160036140448 0.271065502827487 0.0053125653515578 0.0325345581006573 0.0184792322064663 0.0026455902306224 0.0063229831361219 +Nucleotide transmembrane transport 8 9 2.633858694078037 0.0084420613495579 4.029126213592233 9.24271844660194 1.3657020532080593 0.1972377481261837 2.230443861436908 1.484326001257553 1.1744026177454787 0.2553979780962895 3.319891610666072e-06 0.0742352733278267 0.1419203898220533 2.5486927073579494e-05 4.038707593445951e-06 +Cellular hormone metabolic process 9 18 2.6255214286676853 0.0086516362976889 5.441747572815534 17.32766990291262 0.9908884218524354 0.2940959275691314 2.8170777488519256 1.7185203072340225 1.2515909253444888 0.3031653223897966 0.0004625250570057 0.2183067054048652 0.3865877370616545 0.0324089815572542 0.0005728052925544 +Protein insertion into er membrane 6 11 2.6107455220758893 0.0090345094189938 4.451456310679611 12.691747572815531 0.9645901040516046 0.3077872373135509 2.16101217194965 1.431147904526304 1.1733171268605926 0.305304417896891 0.0003644209238643 1.0 0.1898352204968973 0.0950158591305352 0.0004268250114145 +Organelle fusion 19 46 2.6071756299600435 0.0091292521138441 14.74514563106796 45.383495145631066 0.6448767361523368 0.5292766623385164 6.293825046556003 6.576179389035289 1.1045479661060835 0.3741954647136961 0.0861067705481874 1.0 0.3026517532146166 0.5225322311435112 0.0988393064475367 +Cellular respiration 36 99 2.6050580022245327 0.0091858707985059 27.975728155339805 102.1019417475728 0.3887198796668061 0.4496840882999475 12.70690482749566 7.191843824002275 1.6294784865611704 0.3894421445164553 5.002477908327382e-07 0.0002700941600542 1.173840290648286e-05 5.25766731936362e-07 8.768435212967235e-07 +Chloride transport 8 13 2.60008001211174 0.009320202669409 4.33252427184466 12.12621359223301 1.0302584084066435 0.2341882174183942 2.3624510960969567 2.26059366569241 1.2797232968088257 0.2563105728143979 9.47121047108252e-05 0.1471951297158956 0.0390718495583504 0.0427102581002517 0.0001163368707524 +Divalent inorganic cation homeostasis 22 53 2.594060905932605 0.009484968274207 15.361650485436892 54.019417475728154 0.5485088157809707 0.5170537035394376 6.04857242197355 6.215359275440269 1.1779017300469032 0.3778837346959196 0.0045341301407638 0.5891657340012217 0.8288456381676355 0.0700621821699309 0.0060581997950029 +Protein import into mitochondrial matrix 7 10 2.555957624293 0.0105896014067516 3.3276699029126213 9.03883495145631 1.4677455160780188 0.1396272549365287 1.9612536628062327 0.7162785445212654 1.2893924319512868 0.2212161399323651 0.0004123278641389 0.0022827689145391 0.0086772133501052 0.004864195908138 3.802516113035633e-05 +Mitochondrial calcium ion transmembrane transport 5 10 2.552689016961337 0.0106894891086768 3.4684466019417477 9.04126213592233 0.7792467211325117 0.2463779000555085 2.196969341156949 1.2010296388602075 1.3738174116662032 0.263849842646199 0.0005772410354444 0.0742352733278267 0.1419203898220533 0.0058828678879826 0.000660508581979 +Atp synthesis coupled electron transport 16 36 2.544799300337482 0.0109340562814457 11.567961165048544 37.61407766990291 0.6403585631460136 0.4181082416574377 5.189865284224125 3.9859091462453993 1.417482213086961 0.3703097362636519 4.9754070520136414e-05 0.0539251864958397 0.0064162880101964 0.0024540045177978 6.729203894825636e-05 +Regulated exocytosis 13 36 2.504145738535044 0.0122747461215084 9.385922330097088 34.342233009708735 0.5889869251407832 0.528096964379338 3.868480531815476 4.573760415025692 0.9122431884356956 0.3457208176316948 0.1090373727992143 1.0 1.0 0.7901527489342961 0.1243550363527167 +Cristae formation 6 9 2.4905560004561687 0.0127543394415705 4.740291262135922 8.861650485436893 0.8982766043222677 0.3392698633906088 2.216011442046921 0.6593503673812457 1.2485531022675598 0.3418736408093433 2.0094243961943767e-05 1.0 1.0 0.0039601236721776 2.37623382340961e-05 +Calcium ion import 6 13 2.4724812754832395 0.0134178742487192 4.516990291262136 12.686893203883496 1.0417029373125424 0.2391249176108038 2.3196506830054986 1.9148178088324157 1.3383409214307818 0.27915846054651 0.0063311651251972 0.1635258499471353 0.0480988323617951 0.0568103259660642 0.0072862112982979 +L alpha amino acid transmembrane transport 7 10 2.4673391688284827 0.0136121355454819 4.480582524271845 10.533980582524272 0.7590361902351016 0.3223730555033793 2.606398335255894 1.1951807271273862 1.273814103695318 0.3116596719827348 0.1924928117819046 1.0 0.2709026461704186 0.1840986918250508 0.2041790036843356 +Ion homeostasis 42 102 2.463999165918832 0.0137396431165879 28.021844660194176 105.69174757281552 0.8349951537384392 0.4299135801564597 10.40966729997928 11.411952082971936 1.4722934854811005 0.3963893325418664 0.0006703895348211 0.0745157705462292 0.2087971646630951 0.0268759204032917 0.0010651030908424 +Protein localization to endoplasmic reticulum 15 35 2.462606253201233 0.0137931297217388 9.50242718446602 34.50485436893204 0.9935384348474128 0.428255638055916 4.399083524593319 2.6617527855555916 1.1934894982037212 0.3717243536861919 4.687024657257705e-05 0.0305319028295214 0.002067436699404 0.0459551502585406 1.1218711471369454e-05 +Retrograde vesicle mediated transport golgi to endoplasmic reticulum 10 24 2.456185227722778 0.0140420759026103 7.771844660194175 26.825242718446603 1.1714448828781496 0.3436005361805324 3.811248488859092 3.450558374586287 1.1733172803389544 0.345676809182098 0.0053060797549921 0.0213158974187442 0.0100008174701386 0.1001149973848373 0.0062178816105145 +Vitamin transport 7 8 2.442052561828817 0.0146040201768933 3.587378640776699 7.597087378640777 1.658661901456128 0.1256251915839625 1.8073839707699664 1.6422194495621811 1.0713624000848283 0.1994200282768667 0.0006078389490958 0.0058373227860703 0.0215793786244467 0.1101325395908995 0.0007102363863619 +Atp transport 6 7 2.4391213810203136 0.0147230219825198 3.4805825242718447 6.233009708737864 0.5838786306840471 0.3211615036091749 1.83337760624298 0.8807971179633459 1.3636108978108328 0.3170401972517012 6.85039620399253e-07 1.0 1.0 0.0009978388997276 8.150277876805989e-07 +Entry into host 12 28 2.432141058780524 0.0150098604717494 7.968446601941747 31.24514563106796 0.6061616104105989 0.3954837799611526 3.566493820193545 3.4119437173329663 1.31706945612869 0.333413728218646 0.0639223011161252 1.0 1.0 0.3801393668009716 0.031689946206022 +Glycosphingolipid metabolic process 8 10 2.413906201086775 0.0157825247739422 4.764563106796117 9.184466019417476 0.4485135251287195 0.1553285492394019 1.7516723087054535 1.7320372023153958 1.93068386398988 0.2217231968869004 9.47121047108252e-05 0.1471951297158956 0.0390718495583504 0.0427102581002517 0.0001163368707524 +Cellular transition metal ion homeostasis 12 22 2.395665100203232 0.0165902408142801 5.893203883495145 20.42233009708738 0.9608801516152976 0.3243056832171095 2.800529150274697 2.6932649561537056 1.130076157725316 0.3011842711337114 0.002751525950148 0.2695684389372801 0.463832032870012 0.0188096704964068 0.0033497141351698 +Purine containing compound transmembrane transport 6 7 2.389720597426808 0.0168611945903345 3.6432038834951457 8.228155339805825 0.8480777288434221 0.3004167480224937 2.0847056152178514 1.431742605530374 1.2278207398320582 0.2967021731271802 0.0002856166640566 1.0 1.0 0.0039601236721776 0.0003275783690493 +Regulation of lysosomal lumen ph 3 6 2.3848829008878822 0.0170845585112522 2.3567961165048543 5.58252427184466 1.1719038900849827 0.159040563248536 1.2351555175791742 1.4280428037740598 1.4707016211600112 0.2132438131163355 0.00402303968581 4.557535944516599e-05 0.0003495610743441 0.004864195908138 0.0044715029750658 +Sensory perception 15 32 2.36991631415544 0.0177921118820556 8.587378640776699 35.48300970873787 0.2801501425459651 0.4439497622713729 3.631661729137722 5.322347342377745 1.1543967333771397 0.3256888258772134 0.0557563010015049 0.5685207560197068 0.0826562920414128 0.117719273550614 0.0671142439118949 +Regulation of mitochondrial membrane permeability 3 15 2.3445435211761545 0.0190503870640272 3.966019417475728 14.96359223300971 0.2402793183028587 0.524743519159013 2.950861430851842 1.4816465220322803 0.9084604001489732 0.298358218544212 0.1511361490544435 0.1952735388158895 0.3502020618548794 0.0906082167772187 0.1628751544170893 +Sulfur compound transport 5 9 2.3443809011808936 0.0190586963466996 3.504854368932039 9.429611650485436 1.339223354728307 0.2167503093092372 2.046184165461596 2.1092484385198076 1.0728301411615704 0.2604171804663498 0.0035217747563285 0.0108643857486399 0.0390718495583504 0.0073773967902559 0.0040718109564857 +Protein maturation 22 68 2.3225908759399507 0.0202011413388734 16.635922330097088 69.29611650485437 0.7279397561088901 0.5092233260742579 5.6828366082703345 6.923625268615643 1.0037762420957868 0.3621314209884535 0.0009433849754801 0.6239158458722325 0.2991907282092616 0.1058906812292336 0.0013488981570633 +Vitamin transmembrane transport 5 6 2.321595357848815 0.0202547340945262 2.9344660194174756 6.094660194174757 1.6910321805591797 0.1136175735100163 1.344920850275403 0.8913122381585616 1.0580472895861666 0.1862049292817703 0.0004123278641389 0.0022827689145391 0.0086772133501052 0.048077110185513 0.0004723549730038 +Protein insertion into mitochondrial inner membrane 5 8 2.3203816989806354 0.0203202380137292 2.45873786407767 5.665048543689321 0.6692509200083531 0.3406754428009103 1.501050234026552 1.645659707056692 1.2686438529444872 0.3125184360343283 0.0016284767730454 1.0 0.1084298440104649 0.0316561437060345 0.0018160253024119 +Transition metal ion homeostasis 14 26 2.313983270592391 0.020668639824243 6.640776699029126 24.57281553398058 0.9239194315613378 0.3015424973151205 2.934079531592402 2.8081087224394015 1.2471169312381896 0.2974369333820005 0.003522821397689 0.0564048148733258 0.1765294646149295 0.0117040969079316 0.0043390027598481 +Sterol metabolic process 14 40 2.3081784448904057 0.0209892135376379 11.932038834951456 38.44660194174757 1.1656335789111734 0.2523239777622673 4.346099994655023 4.0619669904912925 1.6676089351046874 0.3062687621764124 6.435885065804881e-06 0.0627750690965546 0.0086609949738754 3.093482198747331e-05 9.175860148508649e-06 +Respiratory chain complex iv assembly 3 6 2.3010386794663926 0.0213894448628466 2.7475728155339807 6.451456310679611 1.036831430168084 0.2562354664331627 1.605321530277248 1.669274831081891 1.262804896468415 0.2848709091577191 0.025948359398684 0.1135912525516411 0.0016492758756177 0.0026445688691081 0.0285316537504985 +Mitochondrial cytochrome c oxidase assembly 3 6 2.3010386794663926 0.0213894448628466 2.344660194174758 5.764563106796117 0.9954600272926416 0.2681565835601643 1.449018962088891 1.4364892997002987 1.2150903662861117 0.2820677765861404 0.0167170186699105 0.1006582454154426 0.0011273462404087 0.0016169545741865 0.0184399659986801 +Ph reduction 8 14 2.295276553680857 0.0217172804095922 4.422330097087379 12.509708737864075 1.1966830084586066 0.1930048880851129 1.91475781321527 1.7851607614701208 1.4167744165903868 0.2497649393583847 0.0082367567059641 0.0078974776787256 0.0023011729003655 0.027943905629812 0.0092967787769906 +Regulation of membrane permeability 3 18 2.2923061656117643 0.0218879822991966 4.347087378640777 18.645631067961165 0.1981071582870727 0.6054076942188011 3.2408820958737863 1.6665339124556926 0.7786435166038244 0.2968416300691248 0.2260279052562046 0.225839943305071 0.3982623430868609 0.1308343427210004 0.2417819814559766 +Diol biosynthetic process 5 8 2.2916063852020474 0.0219283666977261 2.5315533980582523 7.747572815533981 0.934609081792458 0.2730932800244148 1.324333323602112 0.9054146354978068 1.183401939154622 0.2688651038177358 0.0001907872283095 0.0607401038440192 0.0002227826640135 0.0031665778749487 0.0002190726437552 +Diol metabolic process 5 8 2.2916063852020474 0.0219283666977261 2.5315533980582523 7.747572815533981 0.934609081792458 0.2730932800244148 1.324333323602112 0.9054146354978068 1.183401939154622 0.2688651038177358 0.0005772410354444 0.0742352733278267 0.0004272672884902 0.0058828678879826 0.000660508581979 +Secondary alcohol metabolic process 14 43 2.2837489425719206 0.022386289885709 12.097087378640778 42.24514563106796 1.5200936296432006 0.2566232504859334 4.463475425703621 3.883072640851752 1.3223501002339118 0.3210874999447533 8.654548155597162e-06 0.0653891722063119 0.0093855493123061 3.79437839603209e-05 1.2306792821268848e-05 +Regulation of neurotransmitter levels 9 27 2.2797743266855752 0.0226210764178804 7.553398058252427 29.356796116504853 0.4081983986281809 0.5631164036271649 3.3846545630909723 3.260736921174588 0.8122711518314254 0.3121999516985374 0.24945960011763 0.4158765777114258 0.6559095677377327 0.744598374754172 0.2729760389119499 +Glycoside catabolic process 4 6 2.2545837151360426 0.0241594705755749 2.995145631067961 5.604368932038835 0.914408298188202 0.1915126053981477 1.4021397407455505 0.554137429771367 1.5051386650706404 0.245673751384095 1.0062291998605608e-05 0.0378187125466048 0.073646168181401 0.0142938954224823 1.1622264404762372e-05 +Sphingoid metabolic process 4 6 2.23867565428481 0.0251770277275427 2.337378640776699 5.174757281553398 0.8258730035764346 0.2192038420096116 1.196784089801513 0.5941001920342514 1.4738240163378542 0.2563928956394505 0.0007436411136795 0.0470522829573702 0.0038356556834428 0.0222658144313338 0.0008311382626552 +Oligosaccharide lipid intermediate biosynthetic process 5 8 2.23176962028569 0.0256301931685036 2.2742718446601944 5.390776699029126 0.4920123476052065 0.3335995467983793 1.5024311055989734 1.8021595402153228 1.3008390374829126 0.2934249582958821 0.0001060978552471 1.0 0.1581956798045988 0.0007287631970396 0.0001248620251216 +Calcium import into the mitochondrion 3 7 2.2183155038586877 0.0265333277996788 2.4563106796116503 6.04126213592233 0.8091317576129835 0.2214807715451704 1.7082137325011066 1.2010296388602073 1.3762222767333927 0.2421218388926935 0.0016284767730454 0.0561990347849709 0.1084298440104649 0.0316561437060345 0.0018160253024119 +Phosphatidylglycerol metabolic process 8 11 2.214813775957233 0.0267728492694583 3.7572815533980584 10.78640776699029 0.7074456860764219 0.3298030384317407 2.521619218643941 1.658461595229837 1.2128783939533223 0.2875854965146425 0.025948359398684 1.0 1.0 0.4518693721129156 0.0285316537504985 +Export across plasma membrane 5 10 2.2107625186152697 0.0270522866387705 3.342233009708738 8.672330097087379 0.659462409318522 0.3364871063656119 2.046038764373277 1.5847916183398325 1.1961171404298503 0.3001696886640556 0.0110778202243423 1.0 1.0 1.0 0.0124755750562623 +Very long chain fatty acid metabolic process 5 9 2.2082515805605376 0.0272267405617951 3.7135922330097086 10.067961165048544 0.1992178042517653 0.4700770172389826 2.204476845835122 1.726504611418437 1.0263308919544554 0.3000888854469281 0.025948359398684 1.0 1.0 0.0206613256108628 0.0285316537504985 +Mitochondrial calcium ion homeostasis 5 11 2.1970627099143867 0.0280159678573346 4.62621359223301 10.509708737864075 0.2790428491871666 0.3774917598770124 2.1634860921400008 1.7383182679254283 1.294226020505384 0.3175561312397286 0.0022225400809937 1.0 1.0 0.0877027952007016 0.0025285330610476 +Er nucleus signaling pathway 8 13 2.1888169237101245 0.0286101491646424 4.563106796116505 13.361650485436892 0.3617919622488442 0.4304556920046536 2.3428051517114805 1.3174649068389608 1.1974910326877934 0.3346175168774911 0.0055136683337418 1.0 1.0 0.2101302413048315 0.0063527072748022 +Metal ion transport 33 98 2.188610315141136 0.0286251754501132 24.868932038834952 99.21116504854368 0.6600358663497399 0.5322554902435589 9.162889792248723 11.473971032908404 1.1670714049066973 0.3920241658733104 0.0179951765394012 0.2337436819955417 0.2364961234198578 0.1251649699141089 0.024795626592105 +Regulation of regulated secretory pathway 7 20 2.178896675644887 0.0293393447937095 5.135922330097087 19.024271844660195 0.5532028818011353 0.482650154445206 2.517120190261048 2.8085156919839167 0.8466655843360735 0.3050640843792452 0.4031672521229384 1.0 1.0 0.8149733650930956 0.4250759542262765 +Neurotransmitter secretion 5 20 2.161213693540165 0.030678836117967 4.878640776699029 19.800970873786408 0.4739837619437216 0.5379742436571602 2.5178643472114657 2.5013004441236206 0.8040908235944773 0.3018218439933647 0.5251057211820888 0.3274019772455256 0.544786927477571 0.8616106546235218 0.5486526862241188 +Maternal process involved in female pregnancy 3 8 2.1566163921018013 0.0310355662476715 2.2111650485436893 8.730582524271844 0.6204980569795152 0.3298515659360952 1.5189967313481476 1.5911578035540987 1.1421028926638763 0.2669654695603632 0.0520943166156094 1.0 0.2567853086841904 0.167027726091139 0.0569238852886385 +Regulation of release of cytochrome c from mitochondria 3 10 2.155569067839908 0.0311173300599176 3.6310679611650487 10.805825242718448 0.7924389389582319 0.4006886058463786 1.815469081442188 1.3603843861930187 0.9712392086725492 0.3199873643457663 0.0520943166156094 0.1389130578490434 0.2567853086841904 0.167027726091139 0.0569238852886385 +Lipid localization 27 81 2.1452156393777093 0.0319356097464624 20.1504854368932 74.27912621359224 1.3966421040883936 0.3001252105784707 7.306180038477171 9.39465098860316 1.572418240819249 0.3627304234720817 7.861134462469076e-05 0.2873388595440179 0.0594071789271723 0.0007896150096177 0.0001238968566433 +Membrane docking 11 30 2.140917221654856 0.032280714088829 7.973300970873787 28.83252427184466 0.3013065671948621 0.638505559524285 3.967313754164099 3.197937811998676 0.8147042438070861 0.3288047187933706 0.0360416703245526 1.0 0.4790872775808428 0.4825812398461412 0.0412332855801814 +Adp transport 4 5 2.13688846590094 0.0326070643543841 2.3689320388349513 4.201456310679611 0.5019942413211786 0.3489879061320977 1.2147179245232118 0.4188493432764195 1.248361495348926 0.3086395860172816 2.130491764661308e-05 1.0 1.0 0.0053511077329156 2.3946565882449505e-05 +Positive regulation of macroautophagy 7 20 2.1345505148308623 0.032797743242922 5.058252427184466 20.34223300970874 0.7197293510270528 0.4154159089925248 2.5734840677494253 3.836065802213299 1.0387053871978371 0.3265560923975395 0.0195828489175404 0.2516504230112798 0.4374181157102795 0.0537446424289807 0.0226061192548448 +Steroid biosynthetic process 14 45 2.1336766079557754 0.0328692621774873 11.728155339805824 44.80825242718446 0.9874364787035632 0.3935759881445143 5.016369659264937 4.35272817633461 1.2862817592315925 0.3680333006848349 3.3324350900765226e-05 0.3746890061856052 0.0649154719665051 0.0021054046256818 4.677254462114467e-05 +Neurotransmitter transport 8 25 2.127296868296278 0.0333954248078356 6.665048543689321 26.191747572815533 0.4855466408473005 0.5442577786721134 3.0345009262529348 3.012857536994118 0.8354081034116676 0.3113132472759617 0.3449948977248364 0.3956263989404739 0.6318350210146663 0.9188165519023396 0.370705165438317 +Inorganic anion transmembrane transport 5 8 2.1218062850066453 0.0338540086490222 3.4101941747572817 8.983009708737864 1.1245392058053427 0.2357455210082705 2.3748669786284156 1.7214248641786654 1.1968417731555627 0.2697184972505711 0.0095851109951209 0.1305522111527444 0.0307863463383066 0.1502583189770621 0.0108065638571881 +Aminoglycan metabolic process 9 13 2.108323040332329 0.0350030563050702 6.650485436893204 15.218446601941748 0.5538240398360251 0.1973407167351751 2.4739761552565955 2.4752855115427597 1.8355272359461776 0.2521795038965069 0.0230701640077096 1.0 1.0 0.4349889140298846 0.0265715083406391 +Organelle membrane fusion 12 30 2.1042253044349395 0.0353587982118563 9.026699029126211 29.49271844660194 0.2503440438263548 0.5991935201964022 4.297974887399588 5.110663265938685 0.9179616425810708 0.3357137012753883 0.3529888800451494 1.0 0.5577603769600794 0.8713096183585349 0.3764265129543394 +Ceramide catabolic process 5 7 2.0917621315388364 0.0364597994360096 3.8592233009708736 6.531553398058253 0.1286784152295923 0.1423502941444668 1.429436503356119 0.7012295128365029 2.0219843992394857 0.2259194528389771 6.691363253360277e-06 0.0561990347849709 0.0055563644779973 0.0024789777341693 7.93204060115495e-06 +Amyloid precursor protein metabolic process 9 18 2.08369867752364 0.037187584604799 5.91747572815534 20.04368932038835 1.2306110398413417 0.2828388345239639 2.574706211328507 3.0661056512526157 1.0127867956133585 0.2841981221806073 0.0034226728092251 0.2333020504203794 0.0153233347656195 0.0095773823981548 0.0040930895465855 +Positive regulation of mitophagy 3 5 2.082305049332989 0.0373146149975185 1.550970873786408 3.8689320388349513 0.8801808224672079 0.2696501569411311 1.2345448550586016 0.6553038465502932 1.2765039068030126 0.275295393283453 6.158540785213102e-05 0.028497516818446 0.0557540441617295 0.0002505083306921 6.914283836040209e-05 +Regulation of mitophagy 3 7 2.0822192537315503 0.037322447394213 2.033980582524272 6.730582524271845 0.7938894190377023 0.2859156513857533 1.5052692819802862 1.0417203147023346 1.2011910390869405 0.2760404746280959 0.0016284767730454 0.0561990347849709 0.1084298440104649 0.0024789777341693 0.0018160253024119 +Maternal placenta development 2 5 2.0780216835113103 0.037707362045861 1.4733009708737863 4.604368932038835 0.272983125836839 0.389685533839971 0.9663090505946808 0.948314979731078 1.207690762449098 0.3027145891958461 0.0695538775916506 1.0 1.0 0.396459747437317 0.0746022325302512 +Regulation of glycoprotein metabolic process 6 12 2.077896078794346 0.0377189317723636 3.592233009708738 10.70631067961165 0.6804974065630551 0.4353046559123504 2.03935499608955 1.985055569049905 0.9883671343018048 0.3255557758909779 0.0082367567059641 1.0 1.0 0.1420085194155307 0.0092967787769906 +Endoplasmic reticulum calcium ion homeostasis 5 8 2.072019559889444 0.0382636171123549 3.412621359223301 8.468446601941748 0.7163576234395546 0.3718536853795897 2.0059706805420334 1.5568434939403433 1.1166052913833018 0.3156746531372333 0.0167170186699105 1.0 1.0 0.0950158591305352 0.0184399659986801 +Peroxisome organization 7 11 2.06324654494497 0.0390892099638369 4.286407766990291 11.196601941747574 0.606295801393023 0.4614466229190617 2.3307796330420754 2.613015983661412 0.9820420209440194 0.3193147518558685 0.1691745416852986 1.0 1.0 1.0 0.1797662267162446 +Tail anchored membrane protein insertion into er membrane 4 8 2.063228565896841 0.0390909173115636 3.237864077669903 9.78883495145631 0.7455035093084798 0.3610190702677224 1.8292985819470449 1.3170176672565082 1.0475888307659635 0.3008611564480194 0.0051716392360647 1.0 1.0 1.0 0.0057418344394404 +Positive regulation of cysteine type endopeptidase activity 11 26 2.0630905485132525 0.0391040259916914 7.196601941747573 28.478155339805824 0.6118231968344265 0.4994143481361404 2.711480107898675 3.3256882629722657 0.9483693928307184 0.340405399390541 0.051793197639452 0.3498897642406863 0.5744906956895812 0.3541740186345088 0.0595558696000059 +Membrane organization 90 230 2.0571956802374447 0.0396674069101867 62.02427184466019 223.60922330097088 0.9560408776070136 0.5603311757674675 21.467957454898308 21.375973545731355 1.611091026762519 0.4273954777865132 1.547657407675082e-14 0.2485042018361758 0.0001304664391471 2.729819554671311e-06 6.630118564969641e-14 +Xenobiotic transport 4 5 2.056237594234025 0.0397596202363785 1.693827160493827 4.08641975308642 0.9732407293076591 0.2870054952103567 1.1547374966527622 1.4159369001791104 1.1259148135419206 0.2680466782257013 0.0616434698760561 1.0 1.0 1.0 0.0661818234522848 +Amide transport 21 40 2.056040434194334 0.0397786189374629 9.512135922330096 37.99757281553398 0.8625203235532012 0.4243895840783888 3.9342099663331425 4.541875701235624 0.963016155404646 0.3369249994514658 0.0508556402938521 0.1403881914917208 0.141777722869203 0.0445840994270362 0.0602951231200232 +L glutamate transmembrane transport 5 7 2.052682901001752 0.0401033414609619 3.116504854368932 6.616504854368932 0.3175170990129407 0.3936177213286974 1.7421166172873912 0.8323084155048082 1.211420518243718 0.3212678134420738 0.1335241000958952 1.0 1.0 0.2857421618237076 0.140100279479938 +C4 dicarboxylate transport 5 6 2.051740575811086 0.0401948811542443 3.441747572815534 7.932038834951456 0.5521079717004741 0.3962643111056436 2.364585978327258 1.2048618010613894 1.0992451565958017 0.3113965023368303 0.199660478430383 0.083126337411673 0.1581956798045988 0.3512730357569927 0.2087954316884295 +Signaling receptor ligand precursor processing 3 6 2.048764931158515 0.0404851064888418 1.0315533980582523 3.3810679611650487 0.922891468458952 0.2951895012340927 0.9835908626114442 1.1503190039790097 1.1501375050950742 0.2673230982951034 0.0141810235873655 0.0963063052639835 0.1820374447866984 0.0877027952007016 0.0156593689964702 +Alcohol biosynthetic process 12 36 2.0438279386212352 0.0409705480738638 9.344660194174756 36.09466019417476 1.0726679306851277 0.3539682718575088 3.792896481514287 3.1078151772256564 1.1587776417647702 0.3419459456532639 0.0001781328801292 0.0667099047189351 0.0014759891253618 0.0011235655849171 0.000237852179763 +Protein processing 16 46 2.0402807470348585 0.0413223712844277 12.08252427184466 45.980582524271846 0.9011703887478908 0.3916089016010577 4.43430858840224 4.931040148104543 1.176660792763282 0.3507158233798557 0.0017936306708002 0.4904368630106878 0.1462054908111973 0.0475676994958329 0.0023853376413599 +Apoptotic mitochondrial changes 7 30 2.0363250763494096 0.0417177233879499 8.33495145631068 31.9126213592233 0.3104951463965997 0.5709370276570955 3.5539451273925566 2.6332703138780773 0.8593316992754738 0.3196919958634499 0.0199073701493497 0.0490886173861251 0.1563084442837106 0.0309574270408548 0.0232820192915909 +Antigen processing and presentation of endogenous antigen 4 6 2.034766825383832 0.0418743405864132 2.6529126213592233 6.463592233009709 1.0779744166035472 0.2832041157954688 1.4492771087670022 1.3990755299770097 1.00991421519493 0.2818848392729987 0.0291172285701084 1.0 1.0 0.048077110185513 0.0314157626389551 +Antigen processing and presentation of endogenous peptide antigen 4 6 2.034766825383832 0.0418743405864132 2.638349514563106 6.390776699029126 1.097011591019633 0.2766562869747734 1.460743657586565 1.3760123823390067 1.0015631459591094 0.2785574288267012 0.0240983907929731 1.0 1.0 0.0423153882822146 0.0260269107064552 +Hormone biosynthetic process 6 8 2.028487642956581 0.0425105032177268 3.2766990291262137 8.762135922330097 0.5893833627772115 0.3611309387757575 1.7820956292372838 1.0801489024333786 1.1172063688590312 0.2892911953740955 0.000127770960294 1.0 1.0 0.4649111194254866 0.0001535370640987 +Glycosylceramide metabolic process 4 5 2.0201755851421903 0.0433651778179347 1.6019417475728157 3.6237864077669903 0.6319353949505291 0.2725232617281626 0.981279191145714 1.1370705133968653 1.4246462713481394 0.2720167900467778 0.0011263184466294 0.0516364610584135 0.0046590638338273 0.026793282710744 0.001257434683291 +Connective tissue development 7 26 2.0181461019401605 0.043576047511934 6.759708737864078 24.91747572815534 0.897701915164713 0.400129048313066 2.7453452066208146 3.8608044632925673 0.8993390896039578 0.3237981500894625 0.3750557574687778 0.462328834210194 0.1224529546175841 0.3614032373697987 0.260705160013166 +Vacuolar acidification 4 9 2.017418291379276 0.043651880016005 3.4757281553398056 8.922330097087379 1.27407749822917 0.1611429668415415 1.4148632661931722 1.303016071016461 1.4195929612668792 0.2212670077717619 0.0010490281052016 0.0032958763634803 0.0006140521777265 0.0082779259052177 0.001197576749496 +Protein targeting to membrane 14 35 2.012111987380286 0.0442081333235251 9.03640776699029 34.86407766990291 0.8678999397376299 0.4369909067843477 3.776027437978551 4.807050937156168 0.9685770296783628 0.3476738150633759 0.0237417804048068 1.0 0.2145288095929067 0.1700821152261711 0.0106872530945536 +Mitochondrial atp synthesis coupled proton transport 4 11 2.00816966488943 0.044625265373922 3.9927184466019416 10.769417475728156 0.5022502301293951 0.29867761594221 2.4440229028906213 0.8937412640542226 1.3849431163992842 0.2834040324316194 0.0471864225344609 0.0032958763634803 0.0124120710913681 0.0082779259052177 0.0507597110616669 +Mitochondrial translation 12 39 2.008025682642477 0.0446405625849068 11.949029126213592 42.29126213592233 -0.1659271391700248 0.6275290115007198 8.747528029690423 4.919016138033724 0.9455427757975456 0.3325795728137262 0.2534165675015885 0.3007677906227077 0.1563084442837106 0.5276333559586852 0.2728739996045939 +Sphingosine biosynthetic process 3 5 2.003469894179915 0.0451268758814384 1.91747572815534 4.20873786407767 0.5236437336099039 0.253544361366954 0.9618880285708752 0.5531212048069467 1.4879043514061585 0.274550754534842 0.0017428204603846 0.028497516818446 0.0013106969968569 0.0079014074338353 0.001897897013483 +Nervous system process 28 84 1.991813177118849 0.0463915599107933 23.060679611650485 100.46844660194176 0.466210961761844 0.5050785047376438 7.1617042179301365 12.55034423055404 1.1784062094355452 0.368401069133876 0.2560795321203629 0.5920163684738493 0.1951976481796501 0.2684185667317733 0.3022926989978192 +Nuclear pore organization 2 12 1.9864759103377143 0.0469805050935581 3.995145631067961 12.49271844660194 0.4246677694998982 0.4445771703419001 2.613440935334279 0.6093489987528347 1.0548914640880422 0.3148672191077474 0.0195902034518293 1.0 0.1169218221283287 0.0031665778749487 0.0211793720212413 +O glycan processing 2 5 1.9855847340361783 0.0470794529295057 1.8762135922330097 5.029126213592233 0.779006640385936 0.3319918611732407 1.1540209287066336 1.1758600296433448 1.0243123329907684 0.2736840802111854 0.0958043754265018 1.0 1.0 0.1101325395908995 0.1024634056988124 +Regulation of mitochondrial gene expression 5 12 1.983776658667592 0.0472807433092159 2.594660194174758 11.4247572815534 0.8803116051858394 0.3443222138925089 2.2226265034531534 1.9350293365530056 0.991093358800792 0.2980671372776958 0.1254226055028103 0.1221118561195742 0.0269433955752302 0.133861047002827 0.1337634592725384 +Metal ion export 4 9 1.9823834774594289 0.0474363374034911 3.779126213592233 8.553398058252426 0.5059205316086877 0.4155863674545267 2.112664358767855 1.499049247815051 1.150738830143596 0.3315496346975708 0.0141810235873655 1.0 1.0 0.396459747437317 0.0156593689964702 diff --git a/msigdb_gobp/metrics.json b/msigdb_gobp/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..a95cbe3a42e777052eaa69e6c2124ed080cd6786 --- /dev/null +++ b/msigdb_gobp/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2974, + "annotations_size": 6335, + "title": "Average number of proteins per term", + "value": 18.147750591949485 +} \ No newline at end of file diff --git a/msigdb_gobp/paths.json b/msigdb_gobp/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..e70c3dff5ec9a0b48dd5ee36c750a2aebcef6825 --- /dev/null +++ b/msigdb_gobp/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/msigdb_gobp/fragment/C220/C220_val_log2fc"} \ No newline at end of file diff --git a/msigdb_gobp/result.tsv b/msigdb_gobp/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..98197b25954a0dc450e9521e6c4f1624f085cf92 --- /dev/null +++ b/msigdb_gobp/result.tsv @@ -0,0 +1,1542 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Anion transport 0.6973638163334211 5.392074423664214 6.964890790114039e-08 0.0004411285211162 0.00044122583156 68 Q9HC21,O00400,Q9UJS0,Q9C0H2,P41440,Q9Y277,Q9UBX3,P45880,P51790,Q9H2J7,P05141,O43681,P21796,Q9NZJ7,Q7L0J3,Q96NB2,P30536,Q9H2D1,P07602,Q00325,Q9H936,O60831,P33527,P08183,Q9BQT8,P53985,P14174,Q9UHG3,P12236,P51798,Q9Y619,O75746,O75915,Q15041,Q4KMQ2,Q15043,Q86VD7,Q9NW15,Q6NUK1,Q8TB61,O43808,P04083,Q15758,P12235,Q9H9B4,Q96S66,P28288,P53007,Q08722 49 +Mitochondrial transmembrane transport 0.7006616115609032 4.766444139643943 1.8750568417935656e-06 0.0118082254053068 0.0059392425463842 54 Q99595,O60830,Q9UJS0,O14925,O96008,O75964,P05141,O43615,P21796,Q96DA6,Q8IYU8,P00846,Q96NB2,O95831,Q9H2D1,Q00325,Q9H936,Q8WWC4,Q9BQT8,P24539,P23786,P12236,Q96AQ8,Q3ZCQ8,O75027,Q9Y619,O75746,Q9BSK2,Q15388,O95202,Q9UJZ1,P56385,P12235,Q6P4A7,P53007 35 +Organic anion transport 0.731328145148123 4.495272893642169 6.948078066892904e-06 0.0430615713407191 0.0126866055585971 43 Q9HC21,O00400,Q9UJS0,P41440,Q9UBX3,P05141,Q9H2J7,Q9NZJ7,Q7L0J3,Q96NB2,Q9H2D1,P07602,Q9H936,O60831,P33527,Q9BQT8,P53985,P14174,P12236,Q9Y619,O75746,O75915,Q15041,Q86VD7,Q6NUK1,Q8TB61,O43808,P04083,Q15758,P12235,Q9H9B4,P53007,Q08722 33 +Anion transmembrane transport 0.7370319323795432 4.464903496363753 8.010484962017728e-06 0.0494805225665255 0.0126866055585971 41 Q9HC21,Q9UJS0,P41440,Q9Y277,Q9UBX3,P45880,P51790,P05141,P21796,Q96NB2,Q9H2D1,Q00325,Q9H936,O60831,P33527,P08183,Q9BQT8,P53985,Q9UHG3,P12236,P51798,Q9Y619,O75746,O75915,Q15041,Q4KMQ2,Q86VD7,Q8TB61,O43808,Q15758,P12235,P53007 32 +Mitochondrial transport 0.6064192601470768 4.354192850903765 1.3355809430626309e-05 0.0811290747158379 0.0169218105486048 86 Q99595,Q53H12,Q5JRX3,O60830,Q9UJS0,Q9Y512,O14925,Q14849,Q9Y371,Q10713,Q9Y5J9,Q9UBX3,P45880,O96008,O75964,P05141,Q8N4H5,Q9NS69,O43615,Q9Y5L4,P00846,O95831,P30536,Q8WWC4,O14737,Q8N8Q8,P51572,Q15070,P24539,Q9Y5J7,P23786,Q9P0J0,P52789,Q15388,Q9UJZ1,P56385,Q6NUK1,Q99797,P12235,Q9Y5J6 40 +Mitochondrial membrane organization 0.6607027089658217 4.2679864320777785 1.972453214893477e-05 0.1174643933574354 0.0185741308480131 51 Q9NX63,Q53H12,Q9Y512,Q9H3K2,Q9Y5J9,P45880,P05141,Q9NS69,Q9Y5L4,Q9BUR5,Q8WWC4,O14737,Q8N8Q8,Q15070,Q6UXV4,Q8IWA4,Q13505,Q9Y5J7,Q9P0J0,P52789,O95202,O60313,Q5XKP0,P12235,Q9Y5J6,P38646,Q16891 27 +Sphingolipid metabolic process 0.7433750238370335 4.2475790000524185 2.1609297727209764e-05 0.12793941582748 0.0185741308480131 32 O15269,Q53H12,P17050,Q96G23,O95470,Q8NCC3,Q9NZ01,P50897,P16278,P04062,Q9NZJ7,P07602,P17900,Q9NRA0,Q99805,P06865,P06280,Q13510,Q16739,P27544,Q6Y1H2,O15121,Q06136,Q9P035 24 +Membrane lipid metabolic process 0.7061279909230761 4.229166340803538 2.3455887416590215e-05 0.1380816975086819 0.0185741308480131 41 Q8NBX0,O15269,Q53H12,P17050,O43292,Q96G23,O95470,Q8NCC3,Q9NZ01,P50897,P16278,Q99735,Q9H490,Q9NZJ7,P04062,P07602,P17900,Q9NRA0,Q92643,Q99805,P06865,P06280,Q13510,Q16739,P27544,Q6Y1H2,O15121,Q06136,Q9P035 29 +Endoplasmic reticulum organization 0.6937164041997336 4.202516755546967 2.6396370311765335e-05 0.1539892503187968 0.0185801117694488 43 Q15363,O14657,Q9H6H4,Q9NPA0,Q9P2W9,Q15041,P57088,Q8NHH9,O95197,P46379,Q12981,Q96A33,Q8N5M9,Q5J8M3,Q00765,Q15629,P61026,Q9NQC3 18 +Mitochondrial respiratory chain complex assembly 0.7032259155965452 4.173636039241944 2.997765227763516e-05 0.1729674898104503 0.0189908427178825 40 Q9Y2R0,Q9Y512,Q86Y39,Q9H061,Q9BRT2,Q69YU5,O96000,O95139,Q9Y6M9,O43676,O95831,P51970,O75438,Q8N8Q8,Q00059,Q15070,Q96CU9,Q9P0J0,Q6DKK2,O43674,O43819,P03886,Q9BSK2,Q8IUX1,O75880,O95168 26 +Protein localization to mitochondrion 0.5858778430137664 4.143732042461309 3.416989831239725e-05 0.1946433081287214 0.0196787550735493 61 Q99595,Q53H12,Q5JRX3,O60830,Q9Y512,O14925,Q9Y371,Q10713,Q9Y5J9,O96008,Q8N4H5,Q9NS69,O43615,Q9Y5L4,O95831,P30536,Q8WWC4,O14737,Q8N8Q8,P51572,Q15070,Q9Y6C9,Q9Y5J7,Q9P0J0,P52789,Q15388,Q99797,Q9Y5J6 28 +Carboxylic acid transport 0.7242589885612044 4.0887952034977575 4.336194661735959e-05 0.2402029248316059 0.0228914943184149 31 Q9UJS0,P41440,Q9UBX3,Q9H2J7,Q9NZJ7,Q7L0J3,Q96NB2,Q9H2D1,P07602,Q9H936,O60831,P33527,Q9BQT8,P53985,P14174,Q9Y619,O75746,O75915,Q15041,P04083,Q15758,Q9H9B4,P53007 23 +Inner mitochondrial membrane organization 0.7813631875300735 4.002196797729795 6.275706412939286e-05 0.3280547915442154 0.0305820000969007 23 Q9NX63,Q53H12,Q13505,Q9Y5J7,O95202,Q9Y512,O60313,Q9P0J0,Q9H3K2,Q9BUR5,Q5XKP0,Q8WWC4,Q9Y5J9,Q9Y5J6,P38646,Q16891,Q6UXV4 17 +Organic acid transmembrane transport 0.7213129547520425 3.9348999338797 8.323136630439265e-05 0.4097993112440347 0.0376621932527381 29 Q9UJS0,P41440,Q9UBX3,Q9H2J7,O43772,Q96NB2,Q9H2D1,Q9H936,O60831,Q02978,P08183,Q9BQT8,P33527,P53985,P23786,Q9Y619,O75746,O75915,Q15041,Q15758,Q9H9B4,O95563,P28288,P53007 24 +Glycoprotein metabolic process 0.5560709641725565 3.908124389950682 9.301541616779652e-05 0.4452734935776486 0.0389232583451707 62 P35610,Q9H4A6,Q6ZXV5,Q9H3H5,Q96AA3,Q9H0U3,Q10472,Q7LGA3,P46977,Q8N4A0,Q9HC07,Q9NX62,Q9BT22,Q9BXS4,Q99805,Q8NCH0,Q9NQX7,Q9BV10,O43505,Q86YN1,O15118,Q8WU17,Q92542 23 +Protein insertion into membrane 0.7137210554855603 3.881352199195381 0.0001038772756687 0.482164017312425 0.0389232583451707 29 Q9NS69,Q9NPA0,Q53H12,O43681,Q8N8Q8,Q9Y5J7,Q9Y512,Q9Y5J6,Q9P0J0,P46379,Q8WWC4,Q96A33,Q5J8M3,Q15006,Q9Y5J9,Q15629,O14737,Q15070 18 +Organophosphate ester transport 0.7307032987584752 3.88001334762788 0.0001044507327336 0.4840420203269479 0.0389232583451707 27 P08183,Q9BSK2,Q9HC21,O00400,P33527,Q4KMQ2,Q14108,Q9H2D1,P12236,Q86VD7,Q6NUK1,P41440,Q8TB61,O43808,P12235,Q08722,Q8WTV0,P05141 18 +Glycoprotein biosynthetic process 0.5908677936824447 3.7410069922263114 0.0001832844210245 0.6868939182673651 0.0645059337328087 53 P35610,Q9H4A6,Q6ZXV5,Q9H3H5,Q96AA3,Q9H0U3,Q10472,Q7LGA3,P46977,Q8N4A0,Q9HC07,Q9BT22,Q9BXS4,Q99805,Q8NCH0,Q9NQX7,Q9BV10,O43505,Q86YN1,O15118,Q92542 21 +Membrane lipid biosynthetic process 0.7140518163440736 3.710767201843728 0.0002066320627367 0.7299503311542251 0.0688954798651201 26 Q8NBX0,O15269,Q9P035,Q53H12,Q99805,P27544,Q96G23,O43292,O95470,Q9H490,P04062,Q6Y1H2,O15121,Q06136,Q9NRA0,Q92643,Q13510,Q16739 18 +Protein transmembrane transport 0.6919671773750058 3.66687932806498 0.0002455285894951 0.788940373672334 0.0777711807225777 28 Q99595,O60830,O14925,O96008,Q9NS69,O43615,Q96DA6,O95831,Q9UGP8,Q99442,Q15629,O75381,P49755,P60059,Q9Y5Y5,Q3ZCQ8,O75298,Q15388,Q07820 19 +Sphingolipid biosynthetic process 0.7695429499116683 3.640304979944699 0.0002723152983508 0.8218897156656519 0.0804645105389321 19 O15269,Q9P035,Q53H12,Q99805,P27544,P04062,O95470,Q96G23,Q6Y1H2,O15121,Q06136,Q9NRA0,Q13510,Q16739 14 +Ceramide metabolic process 0.7305146952704313 3.6289970093195207 0.0002845245365963 0.8351500166480377 0.0804645105389321 22 O15269,Q53H12,Q99805,P27544,P17050,Q96G23,O95470,P04062,O15121,Q8NCC3,P06865,P17900,P06280,Q9NRA0,Q13510,Q16739 16 +Carbohydrate derivative transport 0.8134028209993537 3.622175026115347 0.000292136344498 0.8429127854286388 0.0804645105389321 17 Q9HC21,O00400,Q9NZJ7,Q86VD7,L0R6Q1,Q6NUK1,Q8TB61,P07602,P12236,O43808,Q96AA3,P12235,Q08722,Q8WTV0,P05141 15 +Ion transmembrane transport 0.5826196595700338 3.5704497102660744 0.0003563688712115 0.8954405179541403 0.0940665332968951 152 Q9BVC6,Q9C0H2,P41440,Q70HW3,Q9UBX3,P45880,Q9UDW1,O75964,P51790,Q13586,P20020,P21796,P00846,Q6NXT4,Q96NB2,Q9HC07,Q9H2D1,Q9H936,Q9NRA0,O60831,P61421,Q9UHG3,O75844,Q96ES6,P05067,Q9Y619,P22466,O75746,O75915,Q9UM00,Q15758,P12235,Q9H9B4,Q99623,Q8IUH4,O00400,P13073,Q8N668,P0CG08,Q9Y277,Q13423,O43772,P31930,Q9HD20,O00483,Q8TAD4,Q02978,Q9BQT8,P24539,P53985,P12236,Q9Y6M7,Q96AQ8,P20674,P06576,O75323,Q15041,O95202,Q15043,Q9NW15,Q8TB61,Q9HC21,Q9UJS0,P00403,P05023,P05141,Q9H2J7,Q00325,P33527,P27105,P16615,O75027,Q4KMQ2,Q86VD7,P62942,P35670,Q9H0U3,Q8IYU8,Q8WWC4,Q6P4Q7,P08183,P51798,Q9UJZ1,P56385,P08574,O43808,Q6P4A7,P53007 88 +Transmembrane transport 0.6109217029150953 3.5063733890052378 0.0004542574916968 0.943773945207893 0.1116595644228573 212 Q9BVC6,Q99595,O60830,Q9C0H2,P41440,Q70HW3,Q8IXU6,Q9UBX3,P45880,Q9UDW1,O75964,P51790,Q9NS69,P20020,Q13586,P21796,Q96DA6,P04062,Q9NV96,P00846,Q6NXT4,Q96NB2,Q9HC07,Q9H2D1,Q99442,Q9H936,Q9NRA0,Q15629,O60831,P49755,P61421,Q06481,P60059,Q9UHG3,O75844,Q96ES6,Q3ZCQ8,P05067,Q9Y619,P22466,O75746,O75915,Q9BSK2,Q9UM00,Q16625,Q07820,Q15758,P12235,Q9H9B4,P28288,Q99623,Q8IUH4,O00400,P13073,Q8N668,O14925,P0CG08,Q9Y277,Q13423,Q03518,O43772,P31930,Q9HD20,Q9UGP8,O00483,Q8TAD4,P50542,Q02978,Q9BQT8,P24539,P53985,P23786,P12236,Q9Y6M7,Q96AQ8,P20674,O75298,P52789,Q8TBP6,P06576,O75323,Q15041,O95202,Q15043,Q9NW15,Q8TB61,Q99797,Q8WTV0,Q9HC21,Q9UJS0,P00403,P05023,P05141,Q9H2J7,Q16539,Q7L0J3,L0R6Q1,Q00325,P38435,O75381,P33527,P27105,P16615,Q9Y5Y5,O75027,Q8NE01,Q4KMQ2,Q86VD7,Q6NUK1,P62942,P35670,Q9H0U3,O96008,O43615,Q8IYU8,O95831,Q8WWC4,Q6P4Q7,P08183,P51798,Q15388,Q9UJZ1,P56385,P08574,O43808,Q6P4A7,P53007 127 +Oxidative phosphorylation 0.5400848283613758 3.504031411858018 0.0004582712983416 0.9451862439189828 0.1116595644228573 58 P13073,P14406,P09622,Q9H3K2,Q9BRT2,P00403,O96000,Q9UDW1,O75964,O95139,P00846,P31930,O43676,Q9Y6M9,P51970,O75438,O00483,O14949,P34897,P24539,O43674,P20674,P03886,Q9BSK2,P06576,Q9UJZ1,P56385,P08574,O95168,O75208,P22695 31 +Inorganic anion transport 0.6827110075886151 3.4928483577475995 0.0004778978099131 0.9515976188917952 0.1121289861407317 26 P08183,O43681,P21796,Q4KMQ2,Q9C0H2,P30536,Q9UHG3,Q15043,Q00325,Q9NW15,Q9Y277,Q96S66,Q9UBX3,P45880,P33527 15 +Hormone metabolic process 0.6393351061125563 3.477493839987879 0.0005061246801982 0.9595266488071 0.1145107088948618 32 P42892,Q8NBN7,Q6NUM9,Q8NBQ5,O95470,Q53GQ0,Q6NXT4,P16435,P30536,O75844,Q9HB40,Q14849,P07858,Q969M3,Q9UBM7,P05023,Q8TAD4 17 +Proton transmembrane transport 0.6042794484093121 3.467386989189724 0.0005255446763399 0.9642140773832484 0.1148043284349442 43 O00400,P13073,P00403,P05023,Q13423,Q9UDW1,O75964,P51790,P05141,P00846,P31930,Q00325,Q9H936,O00483,Q9NRA0,Q8TAD4,P61421,P24539,Q96ES6,P20674,Q9UJZ1,P56385,P08574,P12235,Q99623 25 +Nadh dehydrogenase complex assembly 0.653305261925415 3.443230994663166 0.0005748081212237 0.9738120632866292 0.1172114777608359 29 O95139,Q8IUX1,Q9Y6M9,O43676,Q9P0J0,Q86Y39,Q9H061,O75438,P03886,O96000,Q15070,Q96CU9 12 +Protein targeting to mitochondrion 0.5833803818754887 3.420464388320178 0.0006251431991175 0.98096585018183 0.1172114777608359 47 Q99595,Q53H12,Q5JRX3,O60830,Q9Y512,O14925,Q9Y371,Q10713,Q9Y5J9,O96008,Q8N4H5,Q9NS69,O43615,Q9Y5L4,O95831,P30536,O14737,P51572,Q9Y5J7,Q9P0J0,Q15388,Q99797,Q9Y5J6 23 +Organic acid transport 0.5945676601979619 3.415681409695769 0.0006362263546235 0.9822572208426302 0.1172114777608359 44 Q9UJS0,P41440,Q9UBX3,Q9H2J7,O43772,Q7L0J3,Q96NB2,Q9H2D1,Q9H936,O60831,Q02978,P08183,Q9BQT8,P33527,P53985,P14174,P23786,Q9Y619,O75746,O75915,Q15041,O43808,P04083,Q15758,Q9H9B4,O95563,Q6P4A7,P28288,P53007 29 +Intracellular protein transmembrane transport 0.6786723722495069 3.415135446915693 0.0006375030209126 0.982400230768094 0.1172114777608359 25 Q99595,O43615,Q9Y5Y5,O60830,P60059,Q96DA6,Q15388,O95831,O14925,Q3ZCQ8,Q9UGP8,Q99442,Q15629,O75381,O75298,O96008 16 +Establishment of protein localization to membrane 0.5211466884659814 3.4128336632765723 0.0006429117022894 0.9829934282395936 0.1172114777608359 90 Q53H12,Q9Y512,P46379,O60725,Q9H4A6,Q96A33,Q5J8M3,Q15006,Q9Y5J9,Q9NS69,O43681,Q9Y5L4,Q8NBU5,Q9HD20,Q99442,Q8WWC4,Q15629,O14737,Q8N8Q8,P43307,Q15070,Q9NPA0,Q9Y5J7,Q9P0J0,P27105,Q8N2H4,P61026,Q9Y5Y5,Q9UHB9,Q15041,O15118,Q15904,Q9Y5J6,P40855,Q4J6C6 35 +Inorganic ion transmembrane transport 0.5373959966096477 3.4093518319701186 0.0006511743974513 0.9838612731384794 0.1172114777608359 110 Q8IUH4,O00400,P13073,Q8N668,P35670,Q9H0U3,P00403,P05023,Q9UBX3,Q13423,Q9UDW1,O75964,P51790,P05141,Q13586,P20020,Q9H2J7,P21796,P00846,Q8IYU8,P31930,Q6NXT4,Q9HD20,Q9HC07,Q00325,Q9H936,O00483,Q9NRA0,Q8WWC4,Q8TAD4,P61421,Q6P4Q7,Q02978,P24539,Q9UHG3,P27105,P16615,Q9Y6M7,P51798,Q96AQ8,Q96ES6,P20674,O75027,P22466,P06576,Q9UM00,O75323,O95202,Q4KMQ2,Q9UJZ1,Q15043,P56385,P08574,P12235,P62942,Q99623 56 +Cation transmembrane transport 0.5415515902862906 3.403173606511761 0.0006660794316322 0.9853163275840852 0.1172114777608359 116 Q8IUH4,O00400,Q9HC21,P13073,Q8N668,P35670,Q9H0U3,P00403,Q70HW3,P05023,Q13423,Q9UDW1,O75964,P51790,P05141,Q13586,P20020,Q9H2J7,P21796,O43772,P00846,Q8IYU8,P31930,Q6NXT4,Q96NB2,Q9HC07,Q9HD20,Q00325,Q9H936,O00483,Q9NRA0,Q8WWC4,Q8TAD4,P61421,Q6P4Q7,P24539,P27105,P16615,Q9Y6M7,Q96AQ8,Q96ES6,P20674,O75027,P05067,Q9Y619,P22466,P06576,Q9UM00,O75323,O95202,Q4KMQ2,Q9UJZ1,Q15043,P56385,Q9NW15,P08574,Q15758,P12235,Q9H9B4,P62942,Q99623 61 +Lytic vacuole organization 0.6686718366306798 3.299102057250115 0.0009699464088623 0.9978613754707384 0.1617002763195587 24 O75503,O14773,P04062,Q14108,P54802,Q9HC07,P11117,Q8N511,P50897 9 +Glycosylation 0.5643163908488867 3.2479395680863465 0.0011624395679317 0.9993690841833572 0.1888219144319854 47 O75503,P46977,O15118,P04062,Q8N4A0,Q9HC07,Q6ZXV5,Q9H3H5,Q9H0U3,Q96AA3,Q10472,Q9BV10,O43505,Q9BT22,Q9BXS4,Q86YN1 16 +Nucleotide transport 0.8253968253968318 3.2297771816919725 0.0012388672795629 0.9996114503857052 0.1946872914741323 13 Q9BSK2,Q9HC21,O00400,P05141,Q86VD7,P12236,Q8TB61,Q6NUK1,Q9H2D1,O43808,P12235,Q08722 12 +Metal ion homeostasis 0.4929473972994722 3.2249350610764935 0.0012600124625792 0.9996602199295146 0.1946872914741323 77 Q9Y5X3,Q8N511,P35670,P30519,Q96A33,P05023,Q13586,P20020,Q8IYU8,Q7L0J3,Q9HD20,Q9HC07,Q8WWC4,Q8TAD4,P61421,P51572,Q6P4Q7,Q9Y487,P16615,O76024,Q96AQ8,O43819,P05067,O75027,Q8NE01,Q9UM00,O95202,Q9UJZ1,Q15043,P09601,Q15904,O75880,P02786,P62942,Q16891 35 +Establishment of protein localization to mitochondrial membrane 0.6708832788493525 3.1563690284747383 0.001597466109525 0.9999600562985635 0.2218168887628004 20 Q9NS69,Q53H12,Q9Y5J7,Q9Y512,Q9P0J0,Q8WWC4,O14737,Q9Y5J9,Q9Y5J6,Q8N8Q8,Q15070 11 +Electron transport chain 0.4686048416016875 3.0616641989143054 0.0022011023079968 0.999999133974726 0.2218168887628004 66 Q9UJS0,P13073,P09622,Q9H3K2,P00403,O96000,Q9UDW1,O95139,P04062,Q9Y6M9,O43676,P16435,P51970,O75438,Q9H936,O14949,Q9P0J0,O43674,P21912,O43819,P03886,O15121,P08574,O95168,O75208 25 +Endoplasmic reticulum tubular network organization 0.8275780175155836 3.046243308759965 0.0023172024087798 0.999999585631946 0.2218168887628004 11 Q9H6H4,Q15041,Q8NHH9,P57088,O95197,Q9NQC3 6 +Ion transport 0.5617850536738349 3.0302368672239064 0.0024436201224495 0.9999998143269252 0.2218168887628004 198 Q9BVC6,Q9C0H2,P41440,Q70HW3,Q9UBX3,P45880,Q9UDW1,O75964,P51790,Q13586,P20020,P21796,P00846,Q6NXT4,Q96NB2,Q9HC07,Q9H2D1,P07602,Q9H936,Q9NRA0,O60831,P61421,O15173,Q9UHG3,O75844,Q96ES6,P05067,Q9Y619,P22466,O75746,O75915,Q9UM00,P02786,Q15758,P12235,Q9H9B4,P28288,Q99623,Q08722,Q8IUH4,O00400,P13073,Q8N668,Q9Y277,Q13423,Q9NZJ7,Q9HD20,Q8TAD4,Q9BQT8,P24539,P53985,P12236,O76024,Q96AQ8,Q15041,O95202,Q15043,Q9NW15,Q8TB61,Q9HC21,Q9UJS0,P00403,P05023,P05141,Q9H2J7,Q7L0J3,Q00325,P33527,P27105,P16615,O75027,Q8NE01,Q4KMQ2,Q86VD7,Q6NUK1,P62942,Q96S66,P35670,Q9H0U3,O96008,O43681,Q8IYU8,P30536,Q8WWC4,Q6P4Q7,P08183,P14174,P51798,Q9UJZ1,P56385,O95219,P08574,O43808,P04083,Q6P4A7,P53007 96 +Mitochondrion organization 0.555959200684351 3.0193849424373833 0.002532884801023 0.999999894671385 0.2218168887628004 189 Q99595,Q9Y2R0,Q53H12,Q5JRX3,Q96A26,P14406,O60830,Q9H061,Q9BRT2,Q69YU5,P45880,Q8N4H5,Q9NS69,P21796,Q9Y5L4,Q96DA6,P04062,O43676,P51970,Q8N8Q8,P35232,Q15070,Q8IWA4,Q13505,Q9Y5J7,Q5T9A4,Q8N2A8,Q6DKK2,O43674,Q3ZCQ8,P03886,Q8N183,Q9BSK2,Q5THJ4,Q8IUX1,Q5XKP0,P02786,P53365,P12235,Q9UDX5,Q99623,Q96RL7,O14925,Q86Y39,Q9H3K2,P10909,O43464,P36776,Q9BUR5,O75438,Q9Y6C9,Q96CU9,Q9P0J0,O43819,P52789,P27544,O95202,Q99797,Q9Y5J6,Q9Y512,Q9H4A6,Q9NUQ9,Q10713,O96000,P05141,O95139,Q9Y6M9,O14737,Q00059,Q9UG56,Q9NVI7,O75153,O60313,O95168,Q9BWH2,Q9NX63,Q9Y371,Q9Y5J9,O96008,O43615,O95831,P30536,Q8WWC4,P51572,Q6UXV4,Q15388,Q9UJZ1,O75880,P38646,Q16891 90 +Endoplasmic reticulum to golgi vesicle mediated transport 0.4619877400835687 3.006571846308637 0.0026421160914551 0.9999999473687652 0.2218168887628004 64 Q9BSR8,Q9NR31,Q15363,O95070,Q9Y282,Q15437,P24390,P18085,Q15436,Q969M3,Q96PC5,P51572,P49755,Q9P2W9,Q8NHH9,Q13190,O15498,O95249,Q9Y3B3,Q9HCU5,Q96RQ1,O75396,P62820,Q9H0U4,Q8WU17 25 +Ceramide biosynthetic process 0.7965017650189611 2.977768974010334 0.0029035475252179 0.9999999900004852 0.2218168887628004 12 O15269,Q53H12,P27544,P04062,Q96G23,O15121,Q9NRA0,Q13510,Q16739 9 +Amino acid transport 0.7041929992450249 2.975763329897704 0.0029226031466162 0.9999999911407108 0.2218168887628004 17 Q9H2J7,Q15041,Q9UJS0,Q7L0J3,Q96NB2,Q9H936,Q15758,O60831,Q6P4A7,Q9Y619,O75746,O75915 12 +Regulation of hormone levels 0.4574780542663775 2.921109674838118 0.003487870199704 0.9999999997561044 0.2218168887628004 67 O95470,Q53GQ0,Q9BRT2,Q14849,P07858,P05023,Q16836,Q6NXT4,P16435,P30536,Q9HB40,Q8N5M9,Q969M3,Q9UBM7,Q8TAD4,Q12846,P42892,P53985,Q6NUM9,Q8NBQ5,O75844,P40939,P22466,Q8N183,Q8NBN7,Q15043,O95219,P04083,Q9Y394 29 +Dicarboxylic acid transport 0.7451166991324426 2.8993891969565295 0.0037389046941977 0.9999999999505644 0.2218168887628004 14 Q9BQT8,Q15041,Q9UJS0,Q9H2D1,Q9H936,P41440,Q15758,O60831,Q9UBX3,O75746,O75915 11 +Amino acid transmembrane transport 0.7624874155660049 2.8924314729048906 0.0038227256384626 0.9999999999709898 0.2218168887628004 13 Q9H2J7,Q15041,Q9UJS0,Q96NB2,Q9H936,Q15758,O60831,Q9Y619,O75746,O75915 10 +Protein transmembrane import into intracellular organelle 0.7242495424326276 2.8777499139854954 0.0040052251975093 0.9999999999909118 0.2218168887628004 15 Q99595,O43615,Q15388,O60830,O75381,Q96DA6,O95831,O14925,Q9Y5Y5,O96008 10 +Respiratory electron transport chain 0.517440577884203 2.877257257707035 0.0040114841134935 0.9999999999912664 0.2218168887628004 49 Q9UJS0,P13073,P09622,Q9H3K2,P00403,O96000,Q9UDW1,O95139,P04062,Q9Y6M9,O43676,P51970,O75438,Q9H936,O14949,O43674,P21912,O43819,P03886,P08574,O95168,O75208 22 +Cytochrome complex assembly 0.789217360259669 2.8499616699656034 0.0043724498053723 0.9999999999991211 0.2218168887628004 11 Q9BSK2,Q9Y2R0,Q69YU5,P53701,Q8N8Q8,Q15070 6 +Endoplasmic reticulum membrane organization 0.8299186222904944 2.8499463606434694 0.0043726602677511 0.9999999999991224 0.2218168887628004 10 Q15363,Q15041,Q9P2W9,Q8NHH9,Q12981,Q9NQC3 6 +Endoplasmic reticulum unfolded protein response 0.6255275054455454 2.8461436607716855 0.0044252225779413 0.9999999999993718 0.2218168887628004 20 Q15363,P57088,Q6NTF9,Q9GZP9,O76024,Q9BUN8 6 +Monovalent inorganic cation homeostasis 0.5805270988218123 2.833838421733565 0.0045992580351537 0.9999999999997924 0.2218168887628004 28 Q92544,Q93050,O75503,O75787,Q9Y5X3,Q9Y487,Q15904,Q9HC07,P0CG08,Q8N511,Q9Y6M7,P50897,P05023,P61421,P51790 15 +Purine nucleotide transport 0.8245614035087812 2.823625704440251 0.0047483801523804 0.9999999999999196 0.2218168887628004 10 O00400,P05141,Q86VD7,P12236,Q6NUK1,Q8TB61,O43808,P12235,Q08722 9 +Regulation of mitochondrion organization 0.526333145307523 2.8025430579936588 0.0050701447925975 0.9999999999999896 0.2218168887628004 44 P21796,Q96A26,P27544,Q8N2A8,O60313,Q9H3K2,Q9H4A6,Q9NUQ9,P12235,O14737,Q9UG56,Q9Y6C9,P05141 13 +Vacuole organization 0.4931858912970347 2.7872611430082403 0.0053155624373195 0.9999999999999978 0.2218168887628004 53 O75503,P54802,Q8N511,Q9Y371,P50897,Q9P253,P04062,Q9HC07,Q9UHD9,O14773,P16615,P11117,P10253,O75396,P62820,Q9H0U4,Q14108,O95219,Q86Y82 19 +Membrane lipid catabolic process 0.7553627778594858 2.758760236990316 0.0058021087315407 1.0 0.2218168887628004 12 P17050,Q99735,O95470,P04062,P06280,P17900,P50897,Q13510 8 +Cellular monovalent inorganic cation homeostasis 0.5864215617719026 2.7441070286064595 0.0060675751910117 1.0 0.2218168887628004 25 Q92544,Q93050,O75503,O75787,Q9Y487,Q15904,Q9HC07,P0CG08,Q8N511,Q9Y6M7,P50897,P05023,P61421,P51790 14 +Positive regulation of mitochondrion organization 0.6012448022541197 2.740154243878843 0.0061410357230016 1.0 0.2218168887628004 22 P27544,P21796,Q96A26,Q8N2A8,P12235,P05141 6 +Steroid metabolic process 0.4425658332994979 2.733457635498471 0.0062673185264603 1.0 0.2218168887628004 68 P35610,O95470,Q15800,Q53GQ0,Q14849,P05023,P04062,P16435,P30536,Q14534,P38435,Q16850,Q14739,Q15392,Q8NBQ5,P37268,Q9BQE5,Q13510,O15118,Q8WTV0,O75477 21 +Protein targeting 0.4806739133511787 2.7331462694948323 0.0062732466514507 1.0 0.2218168887628004 113 Q99595,Q53H12,Q5JRX3,O60830,Q9Y512,Q96RL7,O14925,P10909,O60725,P46379,O43464,Q9Y371,P13473,Q10713,Q9Y5J9,O00560,O96008,Q8N4H5,Q9NS69,Q9Y5M8,O43615,O43681,Q9Y5L4,Q96DA6,O95831,P30536,Q9UGP8,Q99442,P57105,Q15629,O14737,O75381,Q16543,P43307,P51572,P50542,P60059,Q9Y5J7,Q9P0J0,Q15005,P27105,Q3ZCQ8,Q9Y5Y5,Q9UHB9,Q15041,Q15388,Q5THJ4,Q14108,Q99797,Q9Y5J6,P40855 51 +Liposaccharide metabolic process 0.6458063631483255 2.723389827192621 0.0064615763280218 1.0 0.2218168887628004 18 Q8NBX0,Q99805,P17050,Q9H490,P04062,O43292,P06865,P06280,P17900,Q16739,Q92643,P16278 12 +Vesicle docking 0.680455234782976 2.7186048963791323 0.0065557865114236 1.0 0.2218168887628004 16 Q7Z6M1,Q12846,O15400,Q86Y82,Q13190,P61026,O60499,Q9P253,Q9UNK0 9 +Cation transport 0.5050896070066047 2.713006822514943 0.006667573380535 1.0 0.2218168887628004 149 Q8IUH4,O00400,Q9HC21,P13073,Q8N668,P35670,Q9H0U3,P00403,Q70HW3,P05023,Q13423,Q9UDW1,O75964,P51790,P05141,Q13586,P20020,Q9H2J7,P21796,O43772,P00846,Q8IYU8,P31930,Q6NXT4,Q96NB2,Q9HC07,Q9HD20,P30536,Q00325,Q9H936,O00483,Q9NRA0,Q8WWC4,Q8TAD4,P61421,Q6P4Q7,P24539,O15173,P27105,O75844,P16615,Q9Y6M7,O76024,Q96AQ8,Q96ES6,P20674,O75027,P05067,Q9Y619,P22466,P06576,Q9UM00,O75323,O95202,Q96GC9,Q4KMQ2,Q9UJZ1,Q15043,P56385,Q9NW15,Q86VD7,O95219,P08574,P02786,O43808,Q15758,P12235,Q9H9B4,P62942,Q99623 70 +Aerobic respiration 0.4542069502992947 2.7124242044366933 0.006679305471247 1.0 0.2218168887628004 83 P13073,P14406,P09622,Q9H3K2,Q9BRT2,P00403,O96000,Q13423,Q9UDW1,O75964,O95139,P00846,Q9Y6M9,O43676,P51970,O75438,P11177,O14949,Q15070,P24539,Q96I99,P21912,P03886,Q9BSK2,Q9UJZ1,P56385,P08574,O95168,O75208,P22695 30 +Sensory perception of light stimulus 0.7113601445552884 2.7063550267050807 0.0068026277085577 1.0 0.2218168887628004 14 O60313,O43924,O76024,Q99797,Q13432,P50897,Q9H6K4,Q6P4Q7,O75569 9 +Protein n linked glycosylation 0.5949759551479501 2.694584522854438 0.0070476449244116 1.0 0.2218168887628004 22 P46977,Q9HC07,Q96AA3,Q9H3H5,Q9H0U3,Q9Y385,O75352,Q9BV10,Q9BT22,Q2TAA5,Q86YN1 11 +Cellular ion homeostasis 0.4557307651259953 2.689400217691353 0.0071580543254812 1.0 0.2218168887628004 87 O75503,Q8N511,P35670,Q96A33,P50897,P05023,P51790,Q13586,P20020,Q8IYU8,Q7L0J3,Q9HD20,Q9HC07,Q8WWC4,Q8TAD4,P61421,P51572,Q92544,Q9Y487,P16615,O76024,Q96AQ8,O43819,P05067,O75027,Q93050,Q9UM00,O95202,Q9UJZ1,Q15043,P09601,Q15904,O75880,P62942,Q16891 35 +Lipoprotein metabolic process 0.6218577727352499 2.6868438632604996 0.0072130661284963 1.0 0.2218168887628004 19 Q8IUH4,P04062,Q9BQE5,P50897,Q9NUJ1,Q16739 6 +Regulation of cellular ph 0.5933059437969956 2.682403510853332 0.0073095234454811 1.0 0.2218168887628004 22 Q92544,Q93050,O75503,O75787,Q9Y487,Q15904,Q9HC07,P0CG08,Q8N511,Q9Y6M7,P50897,P61421,P51790 13 +Regulation of ph 0.5933059437969956 2.682403510853332 0.0073095234454811 1.0 0.2218168887628004 22 Q92544,Q93050,O75503,O75787,Q9Y487,Q15904,Q9HC07,P0CG08,Q8N511,Q9Y6M7,P50897,P61421,P51790 13 +L amino acid transport 0.755798406999266 2.6749719339314084 0.0074735506430962 1.0 0.2218168887628004 11 Q15041,Q9UJS0,Q9H936,Q15758,O60831,Q9Y619,O75746,O75915 8 +Transition metal ion transport 0.6841857993027012 2.6403744882044125 0.0082814461246807 1.0 0.2218168887628004 15 O15173,Q9HD20,Q6NXT4,Q9HC07,Q15043,O75027,Q8TAD4 7 +Nucleotide transmembrane transport 0.8242833052276449 2.633858694078037 0.0084420613495579 1.0 0.2218168887628004 9 Q9BSK2,Q86VD7,Q9H2D1,P12236,Q8TB61,O43808,P12235,P05141 8 +Cellular hormone metabolic process 0.6309918137284521 2.6255214286676853 0.0086516362976889 1.0 0.2227972192921117 18 P42892,Q8NBN7,Q6NUM9,Q8NBQ5,O95470,Q53GQ0,P30536,Q9HB40,Q14849 9 +Protein insertion into er membrane 0.7437130302779643 2.6107455220758893 0.0090345094189938 1.0 0.2255522926687415 11 Q9NPA0,O43681,P46379,Q96A33,Q5J8M3,Q15629 6 +Organelle fusion 0.4996477299426544 2.6071756299600435 0.0091292521138441 1.0 0.2255522926687415 46 Q9NX63,Q9P253,Q12981,Q969M3,O60499,Q9Y6C9,Q8IWA4,Q12846,O15400,Q8N2A8,Q13190,O95249,Q9UNK0,O75396,O60313,Q9UJZ1,Q86Y82,P02786,P04083 19 +Cellular respiration 0.4587361424276038 2.6050580022245327 0.0091858707985059 1.0 0.2255522926687415 99 P13073,Q9UJS0,P14406,P09622,Q9H3K2,Q9BRT2,P00403,O96000,Q13423,Q9UDW1,O75964,O95139,P00846,P04062,Q9Y6M9,O43676,P51970,O75438,Q9H936,P11177,O14949,Q15070,Q9NZ45,P24539,Q96I99,O43674,P21912,O43819,P03886,Q9BSK2,Q9UJZ1,P56385,P08574,O95168,O75208,P22695 36 +Chloride transport 0.7100404449213623 2.60008001211174 0.009320202669409 1.0 0.2270250720348946 13 P08183,Q4KMQ2,Q9UHG3,Q9C0H2,Q9NW15,P30536,P51798,Q96S66 8 +Divalent inorganic cation homeostasis 0.4745750409289102 2.594060905932605 0.009484968274207 1.0 0.2270250720348946 53 P35670,Q96A33,Q13586,P20020,Q8IYU8,Q7L0J3,Q9HD20,Q9HC07,Q8WWC4,P51572,Q8TAD4,Q6P4Q7,P16615,O76024,Q96AQ8,P05067,Q8NE01,O95202,Q9UJZ1,Q15043,P62942,Q16891 22 +Protein import into mitochondrial matrix 0.7710623423474483 2.555957624293 0.0105896014067516 1.0 0.2298535035041048 10 Q99595,O43615,Q15388,O60830,Q96DA6,O14925,O96008 7 +Mitochondrial calcium ion transmembrane transport 0.7704198926540066 2.552689016961337 0.0106894891086768 1.0 0.2298535035041048 10 P21796,O95202,Q8IYU8,Q8WWC4,Q96AQ8 5 +Atp synthesis coupled electron transport 0.5179097222276781 2.544799300337482 0.0109340562814457 1.0 0.2316630319162498 36 O95139,O14949,P13073,Q9Y6M9,P09622,O43676,P51970,Q9H3K2,O75438,P08574,O95168,P00403,O75208,O96000,Q9UDW1,P03886 16 +Regulated exocytosis 0.513343086845127 2.5041457385350436 0.0122747461215084 1.0 0.2441440350893139 36 P11279,Q12846,Q99584,Q7L0J3,P09601,P16615,O95219,Q9BRK5,O43760,Q9NRA0,P61026,Q9P253,Q4J6C6 13 +Cristae formation 0.794600936880734 2.4905560004561687 0.0127543394415705 1.0 0.2492238487418802 9 Q9NX63,O95202,Q9Y512,Q9BUR5,Q5XKP0,Q6UXV4 6 +Calcium ion import 0.6877291492566964 2.4724812754832395 0.0134178742487192 1.0 0.251457884384157 13 P21796,Q8IYU8,O75844,P16615,Q8WWC4,Q96AQ8 6 +L alpha amino acid transmembrane transport 0.7537347686984761 2.4673391688284827 0.0136121355454819 1.0 0.251457884384157 10 Q15041,Q9UJS0,Q9H936,O60831,Q9Y619,O75746,O75915 7 +Ion homeostasis 0.449495927635213 2.463999165918832 0.0137396431165879 1.0 0.251457884384157 102 O75503,Q9Y5X3,Q8N668,Q8N511,P35670,P30519,Q96A33,P50897,P05023,P51790,Q13586,P20020,Q8IYU8,Q7L0J3,Q9HD20,Q9HC07,P30536,Q8WWC4,Q8TAD4,P61421,P51572,Q6P4Q7,Q92544,Q9Y487,P16615,O76024,Q96AQ8,O43819,P05067,O75027,Q93050,Q8NE01,Q9UM00,O95202,Q9UJZ1,Q15043,P09601,Q15904,O75880,P02786,P62942,Q16891 42 +Protein localization to endoplasmic reticulum 0.5105214483055179 2.462606253201233 0.0137931297217388 1.0 0.251457884384157 35 Q9Y5M8,P24390,O43681,P60059,O43292,Q15005,Q96HY6,P46379,Q99442,P61026,Q9NQC3,Q15629,P51572,O15258,Q9UHB9 15 +Retrograde vesicle mediated transport golgi to endoplasmic reticulum 0.5537797361324901 2.456185227722778 0.0140420759026103 1.0 0.251457884384157 24 P24390,Q9P2W9,Q96RQ1,O75396,P18085,Q9H4A6,Q12981,O15258,P49755,Q9Y282 10 +Vitamin transport 0.819959541469981 2.442052561828817 0.0146040201768933 1.0 0.2549911567806168 8 Q9HC21,P04062,Q9H2D1,P41440,P38435,Q8WTV0,P33527 7 +Atp transport 0.8345129760700953 2.4391213810203136 0.0147230219825198 1.0 0.2562372095034704 7 Q86VD7,P12236,Q6NUK1,P12235,Q08722,P05141 6 +Entry into host 0.5305054740891552 2.432141058780524 0.0150098604717494 1.0 0.2598018199140241 28 P11279,O00505,O15118,Q14108,P35613,P02786,P07858,Q9BTY2,P35232,Q96J02,Q9P253,Q8WTV0 12 +Glycosphingolipid metabolic process 0.7433769293779793 2.413906201086775 0.0157825247739422 1.0 0.2602055212450904 10 Q99805,P17050,P04062,P06865,P06280,P17900,Q16739,P16278 8 +Cellular transition metal ion homeostasis 0.5546729485131037 2.395665100203232 0.0165902408142801 1.0 0.2602055212450904 22 P05067,O43819,Q9Y487,Q15043,P09601,O75027,Q15904,O75880,P35670,Q8N511,Q8TAD4,P61421 12 +Purine containing compound transmembrane transport 0.8237276710481891 2.389720597426808 0.0168611945903345 1.0 0.2602055212450904 7 Q86VD7,P12236,Q8TB61,O43808,P12235,P05141 6 +Regulation of lysosomal lumen ph 0.8374654968128918 2.3848829008878822 0.0170845585112522 1.0 0.2614267588617944 6 Q8N511,Q9HC07,P50897 3 +Sensory perception 0.5047468254325179 2.3699163141554394 0.0177921118820556 1.0 0.2677269091991034 32 Q9Y5L4,Q9Y5J7,Q9BPW8,Q9Y6M9,Q14108,O60313,O43924,Q13432,O76024,Q99797,Q9H6K4,P50897,Q9Y5J9,Q6P4Q7,O75569 15 +Regulation of mitochondrial membrane permeability 0.6358323375223043 2.3445435211761545 0.0190503870640272 1.0 0.2775089804699112 15 P45880,P52789,P12235 3 +Sulfur compound transport 0.7648524020958113 2.3443809011808936 0.0190586963466996 1.0 0.2775089804699112 9 Q9HC21,O00400,Q8TB61,Q70HW3,Q9UBX3 5 +Protein maturation 0.4089277369952003 2.3225908759399507 0.0202011413388734 1.0 0.2790653254234693 68 O75503,Q5JRX3,Q9BU23,P35670,Q10713,Q6NXT4,Q969M3,Q8TAD4,Q9UG56,Q9BXS4,Q15392,P42892,Q15005,O75844,O76024,Q9BU89,Q9UJZ1,Q8WU17,Q92542,P67812,Q99797,P62942 22 +Vitamin transmembrane transport 0.8234501347708801 2.321595357848815 0.0202547340945262 1.0 0.2790653254234693 6 Q9HC21,P04062,Q9H2D1,P38435,Q8WTV0 5 +Protein insertion into mitochondrial inner membrane 0.7940754728974333 2.3203816989806354 0.0203202380137292 1.0 0.2790653254234693 8 Q53H12,Q9Y5J7,Q9P0J0,Q9Y5J9,Q9Y5J6 5 +Transition metal ion homeostasis 0.526256694159339 2.313983270592391 0.020668639824243 1.0 0.2797774215525208 26 P05067,O43819,Q9Y487,Q15043,P09601,O75027,Q15904,O75880,P35670,Q8N511,P30519,P02786,Q8TAD4,P61421 14 +Sterol metabolic process 0.4838828176844361 2.3081784448904057 0.0209892135376379 1.0 0.2822036776240932 40 P35610,O15118,P37268,P04062,Q15800,P16435,Q9BQE5,Q14849,Q8WTV0,Q14534,Q14739,Q16850,Q15392,O75477 14 +Respiratory chain complex iv assembly 0.8189201227610883 2.3010386794663926 0.0213894448628466 1.0 0.2846683470717092 6 Q8N8Q8,Q9Y2R0,Q15070 3 +Mitochondrial cytochrome c oxidase assembly 0.8189201227610883 2.3010386794663926 0.0213894448628466 1.0 0.2846683470717092 6 Q8N8Q8,Q9Y2R0,Q15070 3 +Ph reduction 0.642048190921943 2.2952765536808575 0.0217172804095922 1.0 0.2884255165508733 14 Q93050,O75503,Q9Y487,P0CG08,Q8N511,P50897,P61421,P51790 8 +Regulation of membrane permeability 0.5818181777585477 2.2923061656117643 0.0218879822991966 1.0 0.2888070749066425 18 P45880,P52789,P12235 3 +Diol biosynthetic process 0.7880087371649874 2.2916063852020474 0.0219283666977261 1.0 0.2888070749066425 8 O15269,P04062,P35270,Q13510,P00374 5 +Diol metabolic process 0.7880087371649874 2.2916063852020474 0.0219283666977261 1.0 0.2888070749066425 8 O15269,P04062,P35270,Q13510,P00374 5 +Secondary alcohol metabolic process 0.4745160711995069 2.2837489425719206 0.022386289885709 1.0 0.2891290131440452 43 P35610,O15118,P37268,P04062,Q15800,P16435,Q9BQE5,Q14849,Q8WTV0,Q14534,Q14739,Q16850,Q15392,O75477 14 +Regulation of neurotransmitter levels 0.5171752885967822 2.2797743266855752 0.0226210764178804 1.0 0.2895040790045914 27 Q12846,Q7L0J3,Q4J6C6,P16615,P41440,P51649,P50897,P21964,O75955 9 +Glycoside catabolic process 0.8087228565297212 2.2545837151360426 0.0241594705755749 1.0 0.2960313626848336 6 P06280,Q9NUJ1,Q9BTY2,P04062 4 +Sphingoid metabolic process 0.8052434924131818 2.23867565428481 0.0251770277275427 1.0 0.2968220771666973 6 O15269,Q13510,Q06136,P04062 4 +Oligosaccharide lipid intermediate biosynthetic process 0.7754591612226934 2.23176962028569 0.0256301931685036 1.0 0.2968220771666973 8 Q96AA3,Q9H3H5,Q9BV10,Q9BT22,Q86YN1 5 +Calcium import into the mitochondrion 0.7867924304763112 2.2183155038586873 0.0265333277996788 1.0 0.3012341068296875 7 Q96AQ8,P21796,Q8IYU8 3 +Phosphatidylglycerol metabolic process 0.671262539201098 2.2148137759572335 0.0267728492694583 1.0 0.3031888024106273 11 Q8NF37,Q96DA6,Q9UJZ1,Q8NCC3,Q92604,P40939,O95674,Q8WUK0 8 +Export across plasma membrane 0.7045983100913277 2.2107625186152697 0.0270522866387705 1.0 0.3038585742138503 10 P08183,Q4KMQ2,P35670,P05023,P33527 5 +Very long chain fatty acid metabolic process 0.7376119688663175 2.2082515805605376 0.0272267405617951 1.0 0.3052768167415443 9 Q6Y1H2,Q15067,Q9NZ01,Q9P035,P28288 5 +Mitochondrial calcium ion homeostasis 0.6680938959447701 2.1970627099143867 0.0280159678573346 1.0 0.3092314073916313 11 O95202,Q8IYU8,Q8WWC4,Q96AQ8,P51572 5 +Er nucleus signaling pathway 0.6393309330000572 2.1888169237101245 0.0286101491646424 1.0 0.3115815918839644 13 Q15363,Q9UM00,P18031,P57088,P16615,O76024,Q96A33,O75477 8 +Metal ion transport 0.4239077735889476 2.1886103151411356 0.0286251754501132 1.0 0.3115815918839644 98 Q8IUH4,P35670,Q9H0U3,P05023,Q9H2J7,Q13586,P20020,P21796,Q8IYU8,Q6NXT4,Q9HD20,Q9HC07,P30536,Q8WWC4,Q9NRA0,Q8TAD4,Q6P4Q7,O15173,P27105,O75844,P16615,O76024,Q96AQ8,O75027,P22466,Q9UM00,O95202,Q4KMQ2,Q9UJZ1,Q15043,P02786,P62942,Q9H9B4 33 +Regulation of regulated secretory pathway 0.5334280330192969 2.178896675644887 0.0293393447937095 1.0 0.3160965123607997 20 Q12846,P11279,P09601,P16615,O95219,Q9P253,Q4J6C6 7 +Neurotransmitter secretion 0.5310823301460711 2.161213693540165 0.030678836117967 1.0 0.3250595962030099 20 Q12846,Q7L0J3,P16615,P50897,Q4J6C6 5 +Maternal process involved in female pregnancy 0.759821178007839 2.1566163921018013 0.0310355662476715 1.0 0.3250595962030099 8 Q15363,Q9BQE5,P35613 3 +Regulation of release of cytochrome c from mitochondria 0.6942217850107124 2.155569067839908 0.0311173300599176 1.0 0.3250595962030099 10 O14737,Q96A26,Q9H3K2 3 +Lipid localization 0.406242431200771 2.1452156393777093 0.0319356097464624 1.0 0.3284287138698698 81 P35610,Q96AA3,Q14849,O15260,P04062,Q9NZJ7,P30536,P07602,Q9BUR5,P17900,Q14534,Q99720,P33527,P08183,P14174,P23786,Q9BQE5,Q9H6V9,Q16739,O15118,Q4KMQ2,Q14108,Q9UJZ1,Q86Y82,O43808,O95674,Q8WTV0 27 +Membrane docking 0.4854718438327172 2.140917221654856 0.032280714088829 1.0 0.3303688590512633 30 Q7Z6M1,Q12846,O15400,P16615,Q13190,Q86Y82,P61026,O60499,Q9Y5Y5,Q9P253,Q9UNK0 11 +Adp transport 0.8339508251936676 2.13688846590094 0.0326070643543841 1.0 0.3326340622947234 5 P12235,Q86VD7,P12236,P05141 4 +Positive regulation of macroautophagy 0.5275541085761022 2.1345505148308623 0.032797743242922 1.0 0.3340413238648091 20 O15269,P27544,P21796,P09601,Q9Y371,P12235,P05141 7 +Steroid biosynthetic process 0.4544977553898227 2.1336766079557754 0.0328692621774873 1.0 0.3342323850632137 45 Q13510,Q16850,Q8NBQ5,P37268,Q15800,Q53GQ0,P16435,P30536,Q14849,Q14534,Q14739,P05023,Q15392,O75477 14 +Neurotransmitter transport 0.5077354041504266 2.127296868296278 0.0333954248078356 1.0 0.3368790066204439 25 Q9H2J7,Q12846,Q7L0J3,Q4J6C6,P16615,P41440,P50897,O75955 8 +Inorganic anion transmembrane transport 0.7526237152668865 2.1218062850066453 0.0338540086490222 1.0 0.3404208647485012 8 Q4KMQ2,Q9UHG3,Q00325,P51798,Q9UBX3 5 +Aminoglycan metabolic process 0.6258865525881091 2.108323040332329 0.0350030563050702 1.0 0.3449157887040911 13 Q96L58,Q8NCH0,P54802,Q9NX62,P06865,P04066,O43505,Q7LGA3,P16278 9 +Organelle membrane fusion 0.4812980498020201 2.1042253044349395 0.0353587982118563 1.0 0.3462101803278365 30 Q12846,O15400,O75396,Q13190,Q86Y82,P04083,Q12981,Q969M3,O60499,O95249,Q8IWA4,Q9UNK0 12 +Ceramide catabolic process 0.759989476977245 2.0917621315388364 0.0364597994360096 1.0 0.3510979840321793 7 P17050,P04062,P06280,P17900,Q13510 5 +Amyloid precursor protein metabolic process 0.5519825478100139 2.08369867752364 0.037187584604799 1.0 0.351396224673417 18 P35610,Q96P70,O95197,Q92542,Q9NQX7,Q9NQC3,P62942,O75298,Q15392 9 +Positive regulation of mitophagy 0.821624742010681 2.082305049332989 0.0373146149975185 1.0 0.351396224673417 5 P27544,P12235,P21796 3 +Regulation of mitophagy 0.7579838959338195 2.0822192537315503 0.037322447394213 1.0 0.351396224673417 7 P27544,P12235,P21796 3 +Maternal placenta development 0.8206604434117615 2.0780216835113103 0.037707362045861 1.0 0.351396224673417 5 Q15363,P35613 2 +Regulation of glycoprotein metabolic process 0.6342570602920807 2.077896078794346 0.0377189317723636 1.0 0.351396224673417 12 Q99805,P35610,P62820,Q92542,Q9NQX7,Q9BXS4 6 +Endoplasmic reticulum calcium ion homeostasis 0.7423791288843321 2.072019559889444 0.0382636171123549 1.0 0.3543977176786346 8 P16615,O76024,Q96A33,P51572,P05067 5 +Peroxisome organization 0.6444154196318481 2.06324654494497 0.0390892099638369 1.0 0.3543977176786346 11 O75381,P22307,Q9Y5Y5,O75192,P28288,P40855,P50542 7 +Tail anchored membrane protein insertion into er membrane 0.7405761893373043 2.0632285658968414 0.0390909173115636 1.0 0.3543977176786346 8 Q9NPA0,O43681,P46379,Q5J8M3 4 +Positive regulation of cysteine type endopeptidase activity 0.4956029800382679 2.0630905485132525 0.0391040259916914 1.0 0.3543977176786346 26 Q9BXK5,Q96A26,Q9NZJ7,Q99538,O95831,Q9P0J0,P49327,O14737,Q9NR28,P51572,O75915 11 +Membrane organization 0.4968940513516398 2.0571956802374447 0.0396674069101867 1.0 0.3564321795881579 230 Q53H12,P41440,P50897,Q15006,Q96CP7,P45880,P51790,Q9NS69,Q9Y5L4,Q9NV96,Q15436,Q15629,O60499,Q8N8Q8,P49755,Q15392,Q8IWA4,Q15070,Q06481,Q13505,Q9P2W9,O15400,Q9Y5J7,O75844,Q9BTV4,Q9NQC3,Q3ZCQ8,O15498,O95249,Q16739,Q9HCU5,O75396,P62820,Q5XKP0,P12235,O43760,P49354,Q9H3K2,Q14849,Q96A33,Q15437,Q9NZJ7,Q9BUR5,Q9P0J0,P52789,Q15041,O15118,O95202,O15121,Q9Y5J6,O15258,Q15363,Q9Y512,Q9H4A6,Q96AA3,Q5J8M3,P05141,Q9H6H4,P57088,Q86XL3,Q12981,O14737,P33527,Q9NPA0,Q8NHH9,P16615,Q13190,P50402,Q4KMQ2,O60313,Q9NR31,Q9NX63,P46379,Q9Y371,Q00765,Q9Y5J9,O75955,O14657,O43681,P30536,Q8WWC4,Q969M3,Q6UXV4,P08183,Q12846,Q9UNK0,Q86Y82,P04083,P38646,Q16891 90 +Xenobiotic transport 0.8157628831256309 2.056237594234025 0.0397596202363785 1.0 0.3564321795881579 5 P08183,P41440,P35670,P33527 4 +Amide transport 0.4575283627146889 2.056040434194334 0.0397786189374629 1.0 0.3564321795881579 40 O00400,Q9BRT2,P41440,Q03518,Q16836,P00367,Q9NZJ7,Q9H2D1,P07602,Q8N5M9,P33527,P08183,Q12846,P53985,P40939,Q16822,P22466,Q8N183,P62820,P04083,O95563 21 +L glutamate transmembrane transport 0.751789871713543 2.052682901001752 0.0401033414609619 1.0 0.3588342770553587 7 Q15041,Q9UJS0,Q9H936,O60831,O75746 5 +C4 dicarboxylate transport 0.7648247978436523 2.051740575811086 0.0401948811542443 1.0 0.3591460819635227 6 Q9UJS0,Q9H936,Q15758,Q9UBX3,O75746 5 +Signaling receptor ligand precursor processing 0.7641881861307214 2.048764931158515 0.0404851064888418 1.0 0.3607432278420441 6 Q8TAD4,Q6NXT4,P42892 3 +Alcohol biosynthetic process 0.463029273030531 2.0438279386212352 0.0409705480738638 1.0 0.3645343006291112 36 O15269,Q13510,P37268,P04062,Q15800,P16435,P35270,Q14739,Q16850,P00374,Q15392,O75477 12 +Protein processing 0.4428648332264169 2.0402807470348585 0.0413223712844277 1.0 0.3652852092969258 46 O75503,P42892,Q6NXT4,Q15005,Q9UJZ1,O75844,Q8WU17,Q92542,P67812,Q99797,Q10713,Q969M3,Q9UG56,Q8TAD4,Q9BXS4,Q15392 16 +Apoptotic mitochondrial changes 0.4736176326525715 2.0363250763494096 0.0417177233879499 1.0 0.3652852092969258 30 Q96A26,Q9H3K2,P12235,O14737,P45880,P52789,P05141 7 +Antigen processing and presentation of endogenous antigen 0.761196186252525 2.034766825383832 0.0418743405864132 1.0 0.3652852092969258 6 Q9NZ08,P10321,P04439,Q03518 4 +Antigen processing and presentation of endogenous peptide antigen 0.761196186252525 2.034766825383832 0.0418743405864132 1.0 0.3652852092969258 6 Q9NZ08,P10321,P04439,Q03518 4 +Hormone biosynthetic process 0.7334685287986629 2.028487642956581 0.0425105032177268 1.0 0.3652852092969258 8 Q8NBQ5,Q53GQ0,P16435,P30536,Q14849,P05023 6 +Glycosylceramide metabolic process 0.807679353317615 2.0201755851421903 0.0433651778179347 1.0 0.3675487140703296 5 P06280,Q16739,P17050,P04062 4 +Connective tissue development 0.4901999527816139 2.0181461019401605 0.043576047511934 1.0 0.3680723479841358 26 P35610,Q16539,O15173,Q15043,Q9NX62,O75844,P43490 7 +Vacuolar acidification 0.7001424339640165 2.017418291379276 0.043651880016005 1.0 0.3682219173121066 9 Q93050,Q8N511,O75503,P50897 4 +Protein targeting to membrane 0.4610706237566376 2.012111987380286 0.0442081333235251 1.0 0.3709973631101196 35 Q15041,O43681,P60059,P27105,Q9UGP8,P46379,O60725,Q99442,P40855,Q15629,Q9Y5Y5,O00560,P43307,Q9UHB9 14 +Mitochondrial atp synthesis coupled proton transport 0.6347739141229981 2.00816966488943 0.044625265373922 1.0 0.3712899790996816 11 P24539,Q9UJZ1,P00846,O75964 4 +Mitochondrial translation 0.4543915863948444 2.008025682642477 0.0446405625849068 1.0 0.3712899790996816 39 P34897,Q6PI48,Q5T160,Q9Y2R0,Q9NWS8,Q567V2,P49411,Q9BRT2,Q9NVS2,Q5JTZ9,Q9BW92,Q07021 12 +Sphingosine biosynthetic process 0.8039446867567838 2.003469894179915 0.0451268758814384 1.0 0.3732098677662047 5 O15269,Q13510,P04062 3 +Nervous system process 0.3967216875714642 1.991813177118849 0.0463915599107933 1.0 0.3803633640693526 84 Q9H0U3,P50897,Q9Y5J9,Q9Y5L4,Q96DA6,P04062,Q9Y6M9,Q8NBU5,P18085,O43924,P17900,Q13432,Q6P4Q7,O75569,O14773,Q9Y5J7,O75844,O76024,P10253,Q9H6K4,P05067,O75746,Q9BPW8,Q14108,O60313,Q92542,Q99797,O00264 28 +Nuclear pore organization 0.618719477874391 1.9864759103377143 0.0469805050935581 1.0 0.3833526147923124 12 Q9NQC3,Q9BTX1 2 +O glycan processing 0.799953282474555 1.9855847340361783 0.0470794529295057 1.0 0.3833526147923124 5 O43505,Q8N4A0 2 +Regulation of mitochondrial gene expression 0.6182631087411061 1.983776658667592 0.0472807433092159 1.0 0.3844974439844454 12 Q9Y2R0,Q9NWS8,Q567V2,Q9BRT2,Q07021 5 +Metal ion export 0.6933505173228638 1.9823834774594289 0.0474363374034911 1.0 0.3846159891406895 9 P35670,P05023,Q4KMQ2,O95202 4 +Collagen fibril organization 0.7451263694025474 1.9592210896787925 0.0500869003261923 1.0 0.3985530078450985 6 Q96AY3,Q92791,P13674 3 +Peroxisomal transport 0.7442617374003705 1.9551391265123743 0.050566651194434 1.0 0.4009258264289607 6 Q9Y5Y5,O75381,P40855,P28288 4 +Chloride transmembrane transport 0.7928844586486449 1.9538316991359337 0.0507211241265457 1.0 0.4016479016770839 5 Q9UHG3,Q4KMQ2,P51798 3 +Glycolipid transport 0.8571271308939699 1.9443818080764863 0.051849425967601 1.0 0.4071505901781715 4 Q9NZJ7,P07602 2 +Macromolecule depalmitoylation 0.7897921273196744 1.9399097784649484 0.0523906554941584 1.0 0.4071505901781715 5 Q9UMR5,P50897 2 +Positive regulation of autophagy 0.4758868243877044 1.9335313653470785 0.0531707730660673 1.0 0.4107070278176755 27 O15269,P21796,P27544,P09601,Q86UE4,Q9Y371,P12235,Q9BXS4,P05141 9 +Early endosome to golgi transport 0.7391688953139727 1.931060144197596 0.0534756150634394 1.0 0.4107070278176755 6 O15260,O60499 2 +Regulation of membrane lipid distribution 0.7136551572414058 1.930935507616638 0.0534910284208485 1.0 0.4107070278176755 8 P08183,Q4KMQ2,Q96AA3,Q96CP7,P33527 5 +Regulation of er to golgi vesicle mediated transport 0.7256488035052054 1.926967571734475 0.0539836713946553 1.0 0.4115361712215901 7 Q9HCU5,Q9NR31,Q9P2W9,Q8WU17,Q6NUQ1,Q969M3 6 +Proteoglycan metabolic process 0.7366547668896456 1.9191510523349096 0.0549652200669958 1.0 0.4159272910797724 6 Q8NCH0,Q7LGA3,Q9NX62 3 +Iron ion homeostasis 0.5427400683501286 1.9182057725100832 0.0550849245802571 1.0 0.4159272910797724 17 Q9Y487,Q15043,P09601,Q8N511,P30519,O75027 6 +Positive regulation of mitochondrial translation 0.6797914115738007 1.9120383922263755 0.0558712698869539 1.0 0.4200010549207454 9 Q9Y2R0,Q9BRT2,Q9NWS8,Q567V2 4 +Negative regulation of leukocyte mediated immunity 0.7785553321602656 1.8891626656953824 0.0588700356439497 1.0 0.4247246398884464 5 Q96FV9,P09601,P04439 3 +Regulation of steroid biosynthetic process 0.6140660353529381 1.8887327924243296 0.0589276422559241 1.0 0.4247246398884464 11 P05023,P16435,P30536,Q13510,O75477 5 +Positive regulation of erad pathway 0.7768997958610632 1.8816652381151269 0.0598814823805349 1.0 0.4247246398884464 5 P51572,Q4ZIN3,P46379 3 +Protein localization to golgi apparatus 0.6433066391535062 1.8796360334523 0.0601576988531089 1.0 0.4247246398884464 10 Q5THJ4,Q9H4A6,Q8N2H4,P40616,P49755 5 +Lysosomal lumen acidification 0.8416861738758419 1.87877476886902 0.0602752535828998 1.0 0.4247246398884464 4 Q8N511,P50897 2 +Selective autophagy 0.4606909390504553 1.878735831406169 0.0602805726862774 1.0 0.4247246398884464 29 O15269,Q5THJ4,P21796,P27544,Q96HY6,O43464,P53365,P12235,Q9Y3C8,Q86VR2,Q99623,Q9Y6I9,P05141 13 +Mitochondrial fusion 0.574916759474088 1.8774547399716237 0.0604557950024731 1.0 0.4247246398884464 14 Q9NX63,Q8N2A8,O60313,Q9UJZ1,Q99536,Q8IWA4,O95140,P02786,Q9Y6C9 9 +Determination of adult lifespan 0.7278234274608517 1.8772022852324608 0.0604903744486269 1.0 0.4247246398884464 6 P04062 1 +Long chain fatty acyl coa biosynthetic process 0.71452669849081 1.8729662716611823 0.0610730426568819 1.0 0.4247246398884464 7 Q53GQ0,Q9NZ01 2 +Lipoprotein localization 0.7140393608228611 1.8705931796427464 0.0614014906788751 1.0 0.4251130529515562 7 Q13432,A6NIH7 2 +Insulin metabolic process 0.7738020674490607 1.8676223754148609 0.0618147253329395 1.0 0.4255627264359535 5 Q8TAD4,Q6NXT4 2 +Neutral amino acid transport 0.7737587602598722 1.8674259213478552 0.0618421327610958 1.0 0.4255627264359535 5 Q9H2J7,Q96NB2,Q15758 3 +Insulin processing 0.8389780771547727 1.8672298401920608 0.0618694981921883 1.0 0.4255627264359535 4 Q8TAD4,Q6NXT4 2 +Atp synthesis coupled proton transport 0.5985186124892917 1.866233387589208 0.062008719786289 1.0 0.4256221560970011 12 P24539,Q9UJZ1,P00846,O75964 4 +Organic cation transport 0.773324351633546 1.865455118190343 0.0621176376503265 1.0 0.4256221560970011 5 O43808,Q9HC21,Q70HW3,Q86VD7 4 +Regulation of protein exit from endoplasmic reticulum 0.7123751863140101 1.862485128821143 0.0625347396929993 1.0 0.4276155841145692 7 Q9NR31,Q9NV96,Q9GZP9,Q9Y385,P51572 5 +Sterol biosynthetic process 0.4746582494346769 1.854833375541057 0.0636200243791811 1.0 0.4320125957814665 25 P37268,Q15800,P16435,Q14534,Q14739,Q16850,Q15392,O75477 8 +Regulation of endoplasmic reticulum tubular network organization 0.7686198550319525 1.8440889392223352 0.0651701796066892 1.0 0.4374384566099559 5 Q15041 1 +Cellular iron ion homeostasis 0.5691656507738718 1.8407570578732513 0.0656571682948949 1.0 0.4374384566099559 14 Q9Y487,Q15904,Q15043,P09601,Q8N511,O75027,P61421 7 +Mitophagy 0.5311007915883378 1.836839198185797 0.0662336373597674 1.0 0.4374384566099559 17 Q5THJ4,P27544,P21796,O43464,P53365,P12235,Q99623,P05141 8 +Membrane fusion 0.4333504914534751 1.8361093221894815 0.0663414898537919 1.0 0.4374384566099559 41 Q12846,Q9P2W9,O15400,O75396,Q13190,Q86Y82,P04083,Q12981,Q969M3,O60499,O15498,O95249,Q8IWA4,Q9UNK0 14 +Glucosylceramide metabolic process 0.9690444145356674 1.8336095910060903 0.0667119675075786 1.0 0.4374384566099559 2 P04062 1 +Establishment of protein localization to endoplasmic reticulum 0.4784917531118578 1.8276573927172173 0.0676009864279632 1.0 0.4374384566099559 23 Q9Y5M8,O43681,Q15005,Q99442,P46379,P61026,Q15629,Q9UHB9 8 +Phospholipid transport 0.5659436130339226 1.820136362496107 0.068738241294777 1.0 0.437937653615996 14 P08183,Q4KMQ2,Q9NV96,Q96GC9,Q14108,Q8WTV0,P33527 7 +Eye photoreceptor cell development 0.8277493828943265 1.8192411545504477 0.0688746466721776 1.0 0.437937653615996 4 Q8NBN7 1 +Positive regulation of release of cytochrome c from mitochondria 0.7631006539419474 1.8189692875074983 0.0689161158266844 1.0 0.437937653615996 5 Q96A26 1 +Regulation of leukocyte mediated immunity 0.4532689013156259 1.812673825311957 0.0698821438514591 1.0 0.4405008769144218 29 Q96FV9,Q9NQT5,P01889,P11279,Q12846,O15400,P09601,O95219,Q9NUQ9,Q9NRA0,P04439 11 +Positive regulation of mitochondrial calcium ion concentration 0.711351197494132 1.7984842854173873 0.0721002967264585 1.0 0.4474153173946678 6 P51572,Q96AQ8,Q9BPX6,Q8IYU8 4 +Copper ion homeostasis 0.7112125024828131 1.7978188998167772 0.0722057112938063 1.0 0.4475764980883203 6 P35670,O43819,P05067,O75880 4 +Neutrophil differentiation 0.8225566042386305 1.7969846346004257 0.0723380591211682 1.0 0.4479585577053769 4 Q14739,Q8N5M9 2 +Photoreceptor cell development 0.7559734879601885 1.786447254428987 0.074026870257438 1.0 0.4544099205736218 5 Q8NBN7 1 +Protein hydroxylation 0.5847313755138872 1.783283002462343 0.0745402468924185 1.0 0.4562439266313735 12 Q96AY3,Q92791,P13674,O75718 4 +Respiratory chain complex iii assembly 0.7550615668729727 1.7822793094349108 0.0747036950592632 1.0 0.4568030001934676 5 Q9BRT2,Q9BSK2,Q69YU5 3 +Retina morphogenesis in camera type eye 0.8183144497409529 1.778773243447365 0.0752769455254749 1.0 0.4589445916456219 4 Q8NBN7 1 +Folic acid metabolic process 0.6922718501726463 1.7640145250388668 0.0777295337614645 1.0 0.4657639105514204 7 P41440,P00374,Q9H2D1 3 +Pyramidal neuron differentiation 0.9660137552492736 1.763239293750241 0.0778601391119107 1.0 0.4657639105514204 3 P04062 1 +Tetrapyrrole metabolic process 0.5070877469907076 1.7605797441109488 0.0783095595197356 1.0 0.468010433544835 18 P30536,P09601,P30519,P22830,O75027,O00264,P33527 7 +Mitochondrial electron transport nadh to ubiquinone 0.4664507649871285 1.7564204953323397 0.0790166358154929 1.0 0.4695782250385999 24 O95139,Q9Y6M9,P09622,O43676,P51970,O75438,O95168,O75208,O96000,P03886 10 +Glial cell proliferation 0.7491855188343914 1.7553865461247722 0.0791932117635949 1.0 0.4701865009581762 5 P30536,P04062,Q96G23 3 +Regulation of macroautophagy 0.3978908351071264 1.7546981703991904 0.0793109491553074 1.0 0.4702206737950266 53 O15269,Q93050,Q5THJ4,P21796,P27544,Q9Y5X3,P04062,O15118,Q9Y487,P09601,O95219,Q9Y371,Q9UHD9,P12235,P61421,P05141 16 +Mitochondrial protein processing 0.7018798094339194 1.7529481948486356 0.0796108998559601 1.0 0.4704618009211824 6 Q9UJZ1,Q99797,Q10713 3 +Glycolipid biosynthetic process 0.6201307249439545 1.751273372466199 0.0798988320999325 1.0 0.470864415654661 10 Q8NBX0,Q99805,O43292,Q9H490,Q92643,Q16739 6 +Cerebellar purkinje cell layer development 0.6885487998965367 1.7456735671202492 0.080867690735543 1.0 0.470864415654661 7 O14949,P54802,P04062 3 +T cell mediated cytotoxicity 0.6993778292929276 1.740886618657271 0.0817034547353514 1.0 0.4731182685086394 6 Q9NUQ9,P01889,P04439 3 +Amyloid precursor protein catabolic process 0.5535338047955958 1.7403110712305008 0.0818044110747608 1.0 0.4732702686380001 14 Q96P70,O95197,Q92542,Q9NQC3,P62942,P49755,O75298,Q15392 8 +Cellular response to unfolded protein 0.4490948308622416 1.737275616733904 0.0823385333121198 1.0 0.4750588420148261 28 Q15363,P57088,Q6NTF9,Q9Y4P3,Q9GZP9,O76024,Q9BUN8 7 +Porphyrin containing compound metabolic process 0.5409543993440967 1.7331903418187549 0.0830618430980703 1.0 0.4750688065268755 15 P09601,P30519,P22830,O75027,O00264,P33527 6 +Positive regulation of protein exit from endoplasmic reticulum 0.8070707070707049 1.7303801300288015 0.0835623815300881 1.0 0.4760500782312123 4 Q9NR31,P51572,Q9NV96 3 +Glycolipid catabolic process 0.6851880021325985 1.729089675042637 0.0837930467757881 1.0 0.4765071376343069 7 P06280,P17900,P17050,P04062 4 +Antigen processing and presentation of exogenous peptide antigen 0.7430737837711844 1.7273494988398566 0.0841049144824368 1.0 0.4769960906412152 5 P04439,Q03518,Q9UIQ6 3 +Cellular response to increased oxygen levels 0.6844199157157066 1.725295905059913 0.0844741595489071 1.0 0.4776922690887156 7 Q8N511,Q9Y487,Q15904,P49327 4 +Regulation of t cell mediated cytotoxicity 0.8057239057239043 1.724571671457077 0.0846046923311032 1.0 0.4776922690887156 4 Q9NUQ9,P01889,P04439 3 +Positive regulation of t cell mediated cytotoxicity 0.8057239057239043 1.724571671457077 0.0846046923311032 1.0 0.4776922690887156 4 Q9NUQ9,P01889,P04439 3 +Steroid hormone biosynthetic process 0.6958460396277302 1.7238376000936613 0.0847371647054096 1.0 0.4780141927059392 6 Q53GQ0,P30536,Q8NBQ5,Q14849 4 +Nerve development 0.6837553142747075 1.7220121851404242 0.0850673111870277 1.0 0.4791054252073308 7 Q9H061 1 +Skeletal muscle acetylcholine gated channel clustering 0.8049359332289812 1.7211721693278752 0.0852195864172888 1.0 0.4791054252073308 4 P49354 1 +Calcium ion transport 0.3861215080051562 1.7210975718561596 0.0852331198435141 1.0 0.4791054252073308 56 Q13586,P20020,P21796,O95202,Q8IYU8,Q4KMQ2,Q9UJZ1,Q9HC07,P30536,P16615,O75844,Q8WWC4,Q9NRA0,O76024,Q96AQ8,P62942 16 +Protein targeting to peroxisome 0.7408351065638132 1.7170632926741236 0.0859676081905707 1.0 0.4828056718858735 5 Q9Y5Y5,O75381,P40855 3 +Myeloid leukocyte activation 0.4872115928056935 1.713789757954471 0.0865673450953372 1.0 0.4857432517085576 19 Q12846,P14174,Q99584,P09601,O95219,P10909,P04083,Q9NRA0,P05067 9 +Phosphatidic acid metabolic process 0.6699342669236856 1.712072331710497 0.0868833395238763 1.0 0.4865196393855738 8 Q8NF37 1 +Cytosolic calcium ion transport 0.4639392261498943 1.7084803528705028 0.0875472488859692 1.0 0.4865196393855738 23 P21796,O95202,Q8IYU8,P16615,Q8WWC4,Q96AQ8,P62942 7 +Response to increased oxygen levels 0.6120154767000974 1.705932847902308 0.088020583085624 1.0 0.4865196393855738 10 Q8N511,Q9Y487,P49327,P00846 4 +Regulation of hormone metabolic process 0.7378698928537138 1.70342541189298 0.0884884854628533 1.0 0.4865196393855738 5 P05023,P16435,O75844 3 +Import across plasma membrane 0.547665982278227 1.7023468278236358 0.0886903713421711 1.0 0.4865196393855738 14 Q15041,P31751,Q15043,P54709,P41440,Q15758,P05023,O75915 8 +Inflammatory response 0.3602042742450433 1.693780452496385 0.0903070099129708 1.0 0.4910685903851244 63 P42785,Q13151,Q8N2K0,Q16539,Q99735,P04062,Q8IV08,P33527,Q06481,P14174,Q86UT6,Q9BQE5,P49327,P28070,P05067,Q96J02,P22466,Q4KMQ2,P09601,O95219,P02786,P04083,Q08722 23 +Negative regulation of production of molecular mediator of immune response 0.9353970390309574 1.69125641402412 0.0907878406379159 1.0 0.4928371640455846 2 P09601 1 +Regulation of blood pressure 0.5344890642028229 1.690060677059367 0.0910163468920715 1.0 0.4936545869531447 15 Q9NZ08,P42892,P42785,Q9UIQ6,Q9Y5X3,P09601,Q9HB40,P05023 8 +Inorganic ion import across plasma membrane 0.7347898502648469 1.689243397796389 0.0911727954960239 1.0 0.49365782860454 5 Q15043 1 +Lipid translocation 0.6770122141770364 1.6886386637520012 0.09128869651454 1.0 0.4938632727750737 7 P08183,Q4KMQ2,Q9NV96,Q96AA3,P33527 5 +Exocytic process 0.5095620996636824 1.6844858329970471 0.0920878151017381 1.0 0.4969133804680674 17 Q7Z6M1,Q12846,Q7L0J3,O95219,P61026,Q9P253 6 +Glucose import 0.607303487730796 1.679515560888015 0.0930516087614379 1.0 0.4995609673760248 10 Q06481,O75298,P52789,Q16539 4 +Protein exit from endoplasmic reticulum 0.4660568739421012 1.678039037087844 0.0933394784832859 1.0 0.5006821305602172 21 Q92544,Q9NR31,O15260,Q9NV96,Q9GZP9,Q9Y385,Q9UBV2,P51572,Q9BUN8 9 +Antigen processing and presentation of peptide antigen 0.5777124496795418 1.6753743498375493 0.0938608060080037 1.0 0.5029764256204379 11 Q9NZ08,P01889,Q9UIQ6,P10321,P04439,Q03518 6 +Multicellular organismal signaling 0.4674935408841876 1.6686501083893284 0.095186742115787 1.0 0.5069396511041435 20 P05023,O75844,Q6PI78,P04062 4 +Cellular response to biotic stimulus 0.4315273608587181 1.655506658768114 0.097821766837058 1.0 0.515987421242933 30 P14174,Q16539,P30536,O75844,Q9NUQ9,Q86UE4,O76024,Q96A33,Q8WTV0 9 +Alcohol metabolic process 0.3699305014761876 1.6550078988296302 0.0979228956652469 1.0 0.5160108047257191 83 O15269,O75477,P35610,Q15800,Q9H3H5,Q14849,Q10713,P04062,P16435,Q9NX62,Q9BW91,Q14534,Q14739,Q16850,Q9UBM7,Q15392,Q6NUM9,P37268,Q9BQE5,P35270,Q13510,P51648,Q8NBN7,O15118,P00374,Q8WTV0 26 +L aspartate transmembrane transport 0.7895622895622855 1.6546815682055642 0.097989107827157 1.0 0.5160108047257191 4 Q9H936,Q9UJS0,O75746 3 +Lysosomal protein catabolic process 0.6693768325249545 1.6507264290658696 0.0987944486599863 1.0 0.5182503577136095 7 Q8N511,P04062 2 +Protein catabolic process in the vacuole 0.6693768325249545 1.6507264290658696 0.0987944486599863 1.0 0.5182503577136095 7 Q8N511,P04062 2 +Erad pathway 0.4162963505527089 1.6481297974746525 0.0993260388763543 1.0 0.5182503577136095 40 Q6NTF9,P27824,Q8WU17,Q9GZP9,P46379,Q9Y385,O76024,Q96A33,Q9UHD9,Q9UBV2,P51572,Q4ZIN3,O75477,Q9BUN8 14 +Peptidyl proline modification 0.4249721631637602 1.6427315059066672 0.1004384971561327 1.0 0.5189868511289567 32 Q9Y680,Q96AY3,Q9NWM8,O95302,Q9BV86,P62942,P13674 7 +Protein kinase c signaling 0.7861767981152673 1.6399986829811652 0.1010054407859444 1.0 0.520073175053272 4 P41440,O75955 2 +Energy derivation by oxidation of organic compounds 0.3971019636225558 1.6384390781300489 0.1013301328755797 1.0 0.520073175053272 119 P13073,Q9UJS0,P14406,P09622,Q9H3K2,Q9BRT2,P00403,O96000,Q13423,Q9UDW1,O75964,O95139,P00846,P04062,Q9Y6M9,O43676,P51970,O75438,Q9H936,P11177,O14949,Q15070,Q9NZ45,P24539,Q96I99,O43674,P10253,P21912,O43819,P03886,Q9BSK2,Q9UJZ1,P56385,P08574,O95168,O75208,P22695 37 +Protein insertion into er membrane by stop transfer membrane anchor sequence 0.7848240147066874 1.6341277078888057 0.1022320379985617 1.0 0.5211119244670682 4 Q9NPA0,Q5J8M3 2 +Protein o linked glycosylation via serine 0.7846046355922037 1.6331754092571138 0.1024321102737788 1.0 0.5211119244670682 4 Q8N4A0 1 +Mitochondrial electron transport ubiquinol to cytochrome c 0.7845536249206623 1.632953969622169 0.1024786780374338 1.0 0.5211119244670682 4 Q9UDW1 1 +Signal peptide processing 0.7845358137183075 1.632876649642004 0.1024949420498764 1.0 0.5211119244670682 4 O75503,P67812 2 +Polyol biosynthetic process 0.5596592474574802 1.630663147210947 0.1029614167738439 1.0 0.5222780918599765 12 O15269,Q13510,P35270,P04062 4 +Positive regulation of autophagy of mitochondrion 0.6766293340978748 1.630614727641904 0.102971639579023 1.0 0.5222780918599765 6 P27544,P12235,P21796 3 +Regulation of neurotransmitter transport 0.5365199838476736 1.6298547242486257 0.1031322045966067 1.0 0.5224558917501609 14 P41440,Q4J6C6,P16615,O75955 4 +Negative regulation of secretion 0.4889259010737647 1.6268154475722374 0.1037762997942888 1.0 0.5246790576191698 18 Q16836,P09601,P40939,P04083,Q8N5M9,Q16850 6 +Ceramide transport 0.720622184017014 1.6238046279004898 0.1044175120568198 1.0 0.5258226859141125 5 Q9NZJ7,P07602 2 +Mannosylation 0.6635260601547384 1.6215893057478108 0.104891313989837 1.0 0.5265931852151166 7 Q6ZXV5,Q9BT22,Q9BV10,O43505 4 +Negative regulation of calcium ion transmembrane transport 0.6634647177667332 1.6212834288376228 0.1049568672847018 1.0 0.5265931852151166 7 P21796 1 +Negative regulation of calcium ion transport 0.6634647177667332 1.6212834288376228 0.1049568672847018 1.0 0.5265931852151166 7 P21796 1 +Proton transporting two sector atpase complex assembly 0.7818348021102711 1.6211468919131682 0.1049861393728006 1.0 0.5265931852151166 4 Q8N511 1 +Tetrapyrrole catabolic process 0.7808710666630455 1.6169595379755914 0.1058870152350817 1.0 0.5284792375472931 4 P30519,P09601 2 +Golgi vesicle transport 0.3991327164172145 1.616929383084378 0.1058935249853387 1.0 0.5284792375472931 124 Q9BSR8,Q12907,Q15363,Q9NR31,Q8N668,Q96RL7,O95070,Q13636,Q9H4A6,Q9Y282,Q15437,O15260,P24390,P18085,Q15436,Q8TBA6,Q8N1B4,P40616,Q12981,O14828,Q969M3,O60499,P49755,Q96PC5,P51572,P11279,Q9P2W9,Q8NHH9,Q6NUQ1,Q8N2H4,Q13190,P61026,O15127,O15498,O95249,Q9Y3B3,Q9HCU5,Q96RQ1,O75396,P62820,Q9H0U4,Q8WU17,O15258,Q4J6C6 44 +Complement activation 0.7808080808080805 1.6166858310767611 0.1059461139202939 1.0 0.5284792375472931 4 P35232,Q07021,Q99623 3 +Antigen processing and presentation 0.4999986647779777 1.616121600833334 0.1060680248365626 1.0 0.5286710757982882 17 Q9NZ08,P01889,Q9UIQ6,P04062,P61026,P10321,P04439,Q03518 8 +Regulation of lipase activity 0.5959357898434942 1.615514979218832 0.1061992191490595 1.0 0.5288060435318289 10 P18085,P16435,P04083,P40616,P50897,P35232 6 +Walking behavior 0.7797979797979916 1.6122957672717588 0.1068975939585747 1.0 0.5289707494800706 4 O15118,O75844,Q8N2K0 3 +Acidic amino acid transport 0.622757584093539 1.610461495181175 0.1072971449221611 1.0 0.5289707494800706 9 Q15041,Q9UJS0,Q9H936,O60831,O75746 5 +Response to endoplasmic reticulum stress 0.3681372533146842 1.6093589211638355 0.1075378821577164 1.0 0.5292556463994561 85 Q15363,Q9Y4P3,P10909,Q9H3N1,Q6ZXV5,P41440,P46379,Q96A33,Q4ZIN3,O75955,P57088,P27824,O95831,Q92575,Q96HY6,Q9Y385,Q9UHD9,O95155,P51572,Q9GZP9,P16615,O95881,O76024,Q9BUN8,Q9UM00,Q6NTF9,O60313,Q8WU17,Q9UBV2,Q9Y3C8,O75477 31 +Golgi organization 0.3952368194422454 1.609049273333662 0.1076055678867402 1.0 0.5292556463994561 49 Q9BSR8,Q12907,Q15363,Q14789,Q7Z3D4,Q9H4A6,Q53FT3,O15260,Q8TBA6,P40616,Q969M3,P49755,Q9P2W9,Q8NHH9,Q13190,Q9BVK6,Q9Y3B3,Q96GC9,P62820,O75396 20 +Reactive nitrogen species metabolic process 0.510820065758697 1.6079755679007046 0.1078405298368063 1.0 0.5294032832572158 16 O43169,P16435,P30536,Q92945,P06280,P35270,Q08722 7 +Mucopolysaccharide metabolic process 0.6490604267437357 1.6059165076556787 0.1082922559756385 1.0 0.5298543063700851 8 Q96L58,Q8NCH0,Q9NX62,O43505,P16278 5 +Mitochondrial electron transport cytochrome c to oxygen 0.778116196031885 1.6049838054277763 0.1084973686781363 1.0 0.5298543063700851 4 P13073 1 +Regulation of immune effector process 0.4088350990244299 1.6047298236677268 0.1085532756117002 1.0 0.5298543063700851 42 Q96FV9,Q9NQT5,P01889,P11279,Q06481,O15400,P14174,Q12846,P09601,O95219,Q9NUQ9,P02786,Q9NRA0,P04083,P35232,Q07021,P04439,Q08722 18 +Regulation of triglyceride metabolic process 0.9145356662180348 1.602645274295153 0.1090129921310234 1.0 0.5298543063700851 2 Q8WTV0 1 +Cellular copper ion homeostasis 0.7160157117348935 1.6024582155528142 0.1090543203402836 1.0 0.5298543063700851 5 P35670,O43819,O75880 3 +Regulation of cysteine type endopeptidase activity 0.4086099047937048 1.60240757193227 0.1090655115243237 1.0 0.5298543063700851 42 Q15041,Q9BXK5,Q96A26,Q9NZJ7,Q99538,O95831,P16435,Q9P0J0,O43464,P49327,P51812,O14737,Q9NR28,P51572,Q15392,O75915 16 +Signal release 0.3789636182326664 1.6010056352702406 0.1093756710125253 1.0 0.5309539278654006 55 Q9BRT2,P50897,Q9P253,Q16836,P00367,Q5T9L3,Q7L0J3,Q8N5M9,Q12846,P53985,P14174,P16615,P40939,Q16822,P22466,Q8N183,P62820,P51809,O95219,P04083,O95563,Q4J6C6 22 +Regulation of oxidative phosphorylation 0.6590667356537872 1.5993326497832314 0.1097467085412624 1.0 0.5319398612156829 7 P14406 1 +Pyrimidine containing compound transmembrane transport 0.9135262449528972 1.5983527070619232 0.1099645034592344 1.0 0.532588019429855 2 Q9BSK2 1 +Long chain fatty acyl coa metabolic process 0.619342573763442 1.5921276951248946 0.111356015356554 1.0 0.5356600746620398 9 Q53GQ0,Q9NZ01 2 +Regulation of amino acid transport 0.7137853438759293 1.5921108585622616 0.1113597976842788 1.0 0.5356600746620398 5 Q15041,Q7L0J3 2 +Amine transport 0.7137853438759293 1.5921108585622616 0.1113597976842788 1.0 0.5356600746620398 5 Q15041,Q7L0J3 2 +Regulation of alcohol biosynthetic process 0.7128108525810506 1.5875875122342928 0.1123796438433808 1.0 0.5370887508995408 5 P16435,O75477 2 +Regulation of cholesterol biosynthetic process 0.7128108525810506 1.5875875122342928 0.1123796438433808 1.0 0.5370887508995408 5 P16435,O75477 2 +Manganese ion transport 0.921575227196225 1.587283347231677 0.1124484851090852 1.0 0.5370887508995408 3 Q9HD20,Q9HC07 2 +Manganese ion transmembrane transport 0.921575227196225 1.587283347231677 0.1124484851090852 1.0 0.5370887508995408 3 Q9HD20,Q9HC07 2 +Zinc ion transport 0.921575227196225 1.587283347231677 0.1124484851090852 1.0 0.5370887508995408 3 Q8TAD4,Q6NXT4 2 +Aminoglycan biosynthetic process 0.6563998359473213 1.586002164455404 0.1127388185643087 1.0 0.5373968514709527 7 O43505,Q8NCH0,Q7LGA3,P06865 4 +Prostate gland development 0.6670041477908084 1.5836421808027337 0.1132751693027804 1.0 0.5391421469069229 6 Q9NZJ7,P07602 2 +Proteoglycan biosynthetic process 0.7116223625927403 1.582068892828512 0.1136338440341226 1.0 0.5400378109198554 5 Q8NCH0,Q99805,Q7LGA3 3 +Positive regulation of cell killing 0.6662707402449344 1.5800557017644703 0.1140941107979995 1.0 0.5414229891887407 6 Q9NUQ9,P11279,P01889,P04439 4 +Regulation of autophagy of mitochondrion 0.5289043590633299 1.5800463965704534 0.1140962416048885 1.0 0.5414229891887407 14 Q5THJ4,P27544,P21796,P30536,P12235,P05141 6 +Leukocyte degranulation 0.5510306394737619 1.577631982463748 0.1146501804803088 1.0 0.5424773603738614 12 Q12846,P11279,Q99584,P09601,O95219 5 +Camera type eye development 0.4345795063975565 1.574277181176144 0.1154233827942705 1.0 0.5432445245183537 27 Q8NBN7,Q8NF37,P54802,Q99797,P08670,O75569 6 +Lipoprotein biosynthetic process 0.5274288872148796 1.570371065934023 0.1163288097650943 1.0 0.5458837110087944 14 Q8IUH4,Q16739,P04062 3 +Sarcoplasmic reticulum calcium ion transport 0.6531334700881288 1.569655289747062 0.1164953281160643 1.0 0.5462604763991618 7 O75844 1 +Estrogen metabolic process 0.7088553385331154 1.5692123372801527 0.1165984704459519 1.0 0.5463397265348414 5 O95470,Q53GQ0 2 +Regulation of endoplasmic reticulum unfolded protein response 0.6413875771067363 1.566643328871727 0.1171980840614912 1.0 0.5470634663117646 8 O76024,Q96HY6,P57088 3 +Fatty acid transmembrane transport 0.6623516079833532 1.5608733622151605 0.1185536335143802 1.0 0.5514223702743014 6 P50416,P28288,O43772,P23786 4 +Antigen processing and presentation of peptide antigen via mhc class i 0.6131870492387912 1.5590079389618936 0.1189945011525936 1.0 0.552313094583381 9 Q9NZ08,Q9UIQ6,P10321,P04439,Q03518 5 +Negative regulation of immune effector process 0.6394833895489171 1.5568766672037646 0.1194997701510531 1.0 0.5531333455653394 8 Q96FV9,P09601,P04083,P04439,Q08722 5 +Granulocyte differentiation 0.6612826216804727 1.55563620181619 0.1197946251169133 1.0 0.5531333455653394 6 Q14739,Q8N5M9 2 +Neuromuscular process 0.4532323631982451 1.5548154940788466 0.1199900179440729 1.0 0.5534306961694755 20 P17900,O14773,O75844,P04062 4 +Adipose tissue development 0.5574523908265294 1.5545402772330306 0.1200555969953678 1.0 0.5534306961694755 11 P43490,O15173 2 +Protein lipid complex subunit organization 0.659597669266877 1.5473770418896018 0.121772353938619 1.0 0.5569876261380157 6 Q8WTV0 1 +Atp biosynthetic process 0.4519344546224543 1.5443988103944293 0.1224917480647154 1.0 0.5574009255486929 20 P24539,Q9UJS0,P00846,Q9UJZ1,P56385,Q9NRA0,P00403,O75964 8 +Regulation of cellular respiration 0.5125447262320582 1.5423782062572564 0.1229817143886797 1.0 0.5581778941845624 15 Q9NZ45,P14406 2 +Glycosaminoglycan catabolic process 0.7636363636363761 1.5418979300886515 0.1230983990436813 1.0 0.5581778941845624 4 P54802,P16278,P04066 3 +Aminoglycan catabolic process 0.7636363636363761 1.5418979300886515 0.1230983990436813 1.0 0.5581778941845624 4 P54802,P16278,P04066 3 +Autophagy of mitochondrion 0.4126615240705177 1.5407756520792657 0.123371397189522 1.0 0.5581778941845624 34 Q5THJ4,P21796,P27544,P04062,P30536,O43464,Q9BWH2,P53365,P12235,P52789,Q99623,P05141 12 +Leukocyte mediated immunity 0.3953277804792347 1.5395502154792065 0.1236700286589924 1.0 0.558353529099824 46 Q96FV9,Q9NQT5,P01889,P11279,Q12846,O15400,Q99584,P09601,O95219,Q9NUQ9,P02786,Q9NRA0,Q8N5M9,Q07021,P04439 15 +Regulation of glucose import 0.6080901757491465 1.5315145388193516 0.1256422759899931 1.0 0.5604078127497353 9 Q06481,O75298,P52789,Q16539 4 +Peptidyl proline hydroxylation 0.6561618437684894 1.530519610451433 0.1258881631677932 1.0 0.5604078127497353 6 O75718,P13674 2 +Skeletal system morphogenesis 0.4879544620189787 1.5294269151652289 0.1261586442837625 1.0 0.5604078127497353 17 Q16539,O95470,Q9NX62,O75844,O75569 5 +Attachment of gpi anchor to protein 0.6999536434921376 1.5277764892611043 0.1265680415003118 1.0 0.5607052747583746 5 Q9H490,O43292 2 +Transepithelial transport 0.7593574104710097 1.5232128846962445 0.1277054535671955 1.0 0.5612751673711985 4 P08183,P33527 2 +Glycerolipid biosynthetic process 0.3933810638565267 1.5185551840042253 0.1288744990906529 1.0 0.5633318848023995 46 Q9NUQ2,Q8NF37,O43292,Q9H490,Q92604,Q8NCC3,Q9NX62,Q9NTJ5,O14735,O95674,Q10713,Q9UBF8,Q9UG56,Q8WUK0,Q8WTV0,Q96N66 16 +Nucleobase transport 0.9040727027936676 1.5176341502993098 0.1291066527821853 1.0 0.5633318848023995 3 P12235,Q9Y277 2 +Mitochondrial adp transmembrane transport 0.9040727027936676 1.5176341502993098 0.1291066527821853 1.0 0.5633318848023995 3 P12235,P12236 2 +Posttranslational protein targeting to membrane translocation 0.697033939939515 1.5141615872259837 0.1299848615688339 1.0 0.5642364687663872 5 P60059,Q99442,Q9UGP8 3 +Positive regulation of response to endoplasmic reticulum stress 0.6047629606152958 1.5135337459882083 0.1301441359875035 1.0 0.5642364687663872 9 P57088,P46379,Q9UHD9,P51572,Q4ZIN3 5 +Pinocytosis 0.6416314519891058 1.5119223795050576 0.1305536100394693 1.0 0.5645441089420055 7 Q9Y5X3,P50897 2 +Negative regulation of lymphocyte mediated immunity 0.7560561167035036 1.5087847025236547 0.131353811285634 1.0 0.5672299894304648 4 Q96FV9,P04439 2 +Myeloid leukocyte mediated immunity 0.484895983188683 1.507310069674484 0.1317311976966422 1.0 0.5678872177189835 17 Q12846,Q99584,P09601,O95219,Q8N5M9 5 +Positive regulation of organic acid transport 0.6949134146199787 1.504266129858374 0.1325128563834794 1.0 0.5695176018923624 5 Q15041 1 +Estrogen biosynthetic process 0.8906460296096914 1.5009774674223852 0.1333613896464627 1.0 0.5720632344682809 2 Q53GQ0 1 +Cotranslational protein targeting to membrane 0.5279912231213469 1.5004417777512085 0.1335000044652061 1.0 0.5720632344682809 13 Q15041,Q99442,Q15629,P43307,Q9UHB9 5 +Negative regulation of neuron projection development 0.4713526923597943 1.495832886196372 0.1346972091384812 1.0 0.5725789968549663 18 Q9NR77,Q9NQC3,Q96G23 3 +Response to ph 0.7527247108932821 1.4942144747296708 0.135119570498345 1.0 0.5725789968549663 4 P51798,P04062 2 +Positive regulation of toll like receptor signaling pathway 0.6927462830357028 1.4941470445998175 0.135137190109023 1.0 0.5725789968549663 5 Q9NQC3,O75955 2 +Calcium ion import into sarcoplasmic reticulum 0.8882907133243665 1.4909483429905082 0.1359750577326575 1.0 0.5725789968549663 2 O75844 1 +Amyloid precursor protein biosynthetic process 0.69144332585187 1.488060151278888 0.1367350311836332 1.0 0.5725789968549663 5 Q9NQX7,P35610 2 +Regulation of leukocyte degranulation 0.6365158595911262 1.4861634882366763 0.1372358825455195 1.0 0.5725789968549663 7 Q12846,P11279,P09601,O95219,Q9NRA0 5 +Regulation of leukocyte mediated cytotoxicity 0.6357818729131506 1.4824636122404806 0.1382169787862213 1.0 0.5725789968549663 7 Q9NUQ9,P11279,P01889,P04439 4 +Regulation of water loss via skin 0.689742304482829 1.4801103971606178 0.1388437873160732 1.0 0.5725789968549663 5 P04062 1 +Regulation of mast cell activation 0.7494949494949502 1.4800791722223827 0.1388521191653997 1.0 0.5725789968549663 4 Q9NRA0,P09601,O95219 3 +Regulation of mast cell activation involved in immune response 0.7494949494949502 1.4800791722223827 0.1388521191653997 1.0 0.5725789968549663 4 Q9NRA0,P09601,O95219 3 +Regulation of tor signaling 0.5247850217023983 1.4799320961656115 0.1388913691148283 1.0 0.5725789968549663 13 O75844,P04062 2 +Regulation of cardiac conduction 0.7494210742059366 1.4797557434775293 0.1389384433362277 1.0 0.5725789968549663 4 P16615,Q6PI78 2 +Mast cell activation involved in immune response 0.6351247822612742 1.4791505181373803 0.139100090948665 1.0 0.5725789968549663 7 Q9NRA0,P09601,O95219,Q99584 4 +Mast cell activation 0.6351247822612742 1.4791505181373803 0.139100090948665 1.0 0.5725789968549663 7 Q9NRA0,P09601,O95219,Q99584 4 +Negative regulation of release of cytochrome c from mitochondria 0.644880682439913 1.4750244220647597 0.1402059776828876 1.0 0.5747032832747649 6 O60313,Q9H3K2,P10909 3 +Regulation of anion transport 0.5711736361042585 1.4748562746518556 0.1402511879941257 1.0 0.5747032832747649 10 P08183,Q15041,P14174,Q7L0J3 4 +Neuron apoptotic process 0.3852215425834049 1.473862205968712 0.1405186954431954 1.0 0.5754171566382122 48 Q01105,Q96A26,P04062,O95831,P09601,Q92542,Q15058,P49327,O76024,P50897,Q9NR28 11 +Sensory system development 0.4077337061832038 1.4727337767550168 0.1408228351300389 1.0 0.5754171566382122 31 Q8NBN7,Q8NF37,P54802,Q99797,P08670,O43819,O75569 7 +Iron coordination entity transport 0.8839165545087545 1.472322142529737 0.1409339066715635 1.0 0.5754171566382122 2 O15173 1 +Heme transport 0.8839165545087545 1.472322142529737 0.1409339066715635 1.0 0.5754171566382122 2 O15173 1 +Iron ion transmembrane transport 0.8839165545087506 1.4723221425297206 0.140933906671568 1.0 0.5754171566382122 2 Q15043 1 +Phosphatidylserine metabolic process 0.6879757698745534 1.471850613350447 0.1410612224560605 1.0 0.5754171566382122 5 Q8NCC3,Q8N2K0 2 +Nuclear pore complex assembly 0.6229015241610496 1.47150342215024 0.1411550227198594 1.0 0.5754292592859136 8 Q9NQC3 1 +Regulation of autophagy 0.3616844489032716 1.46927477032873 0.1417582770955223 1.0 0.5762079777275815 90 O15269,Q9Y5X3,Q9Y371,P05141,P21796,P04062,Q9NZJ7,P30536,P07602,Q86UE4,Q9UHD9,P61421,Q9BXS4,Q9NZ45,Q9Y487,O75844,Q93050,Q5THJ4,P10619,P27544,O15118,O75396,P09601,O95219,P12235 25 +Outer mitochondrial membrane organization 0.6873875638914131 1.4690994801840764 0.1418058087459903 1.0 0.5762079777275815 5 Q9NS69,Q9Y512 2 +Er overload response 0.7467826014077055 1.4682013344935878 0.1420495418939098 1.0 0.5762079777275815 4 O76024,Q96A33 2 +Response to estrogen 0.5698952658342977 1.4675510467329225 0.1422262136253249 1.0 0.5762079777275815 10 P09601,P04062 2 +Amino acid import across plasma membrane 0.6865498777679332 1.46518075595041 0.1428716085127042 1.0 0.5773522304367745 5 Q15041,O75915 2 +Phosphatidylinositol biosynthetic process 0.4397885072044171 1.464868678609114 0.1429567497069157 1.0 0.5773522304367745 21 Q9H490,O43292,Q9NX62,Q9NTJ5,O14735,Q10713,Q9UBF8,Q96N66 8 +Camera type eye morphogenesis 0.6322022122186077 1.4644052696412997 0.1430832491478462 1.0 0.5773522304367745 7 Q8NBN7 1 +Phosphatidylcholine acyl chain remodeling 0.8904979755599762 1.4635239327581222 0.1433240697935369 1.0 0.5773522304367745 3 Q8NF37 1 +Oligosaccharide metabolic process 0.6303927338858415 1.4552682676017847 0.1455950079197481 1.0 0.5824448729025041 7 P06280,P17900,P10253 3 +Regulation of blood circulation 0.4361566845401955 1.4551266467866597 0.1456342034218731 1.0 0.5824448729025041 22 P42892,O75844,P16615,Q6PI78,P05023 5 +Maintenance of protein location in cell 0.440572608581715 1.452828123925433 0.1462714812652865 1.0 0.5833255980235814 20 P24390,Q5THJ4,O43292,Q9UH99,P30536,Q9H4A6,O15258,P52789 8 +Response to food 0.6829931688021413 1.448532934309482 0.1474680621176043 1.0 0.5842465125172128 5 P80303 1 +Glycoside metabolic process 0.5918337823608768 1.4434235065893235 0.1489012062615669 1.0 0.5869876426054924 9 P06280,Q9NUJ1,Q9BTY2,P04062 4 +Nls bearing protein import into nucleus 0.5902853177733434 1.4350022567035845 0.1512864545268712 1.0 0.5899809800638673 9 O00505,Q8NFH5 2 +Positive regulation of membrane permeability 0.5376078843214914 1.434969952459423 0.1512956601518413 1.0 0.5899809800638673 11 P45880 1 +Carbohydrate derivative catabolic process 0.4019457718894852 1.429164073144473 0.1529570811144456 1.0 0.5909937288476909 33 P35610,P17050,P04062,P54802,P17900,Q9BW91,P06280,Q9H773,Q9BTY2,Q13126,Q9NUJ1,P16278 12 +Neutrophil migration 0.5058427583548402 1.4279302625038364 0.153311932102373 1.0 0.5914927465703612 14 Q8N5M9,Q8NHP6 2 +Lipoprotein catabolic process 0.7365899773859024 1.4235129522906904 0.1545875100878557 1.0 0.5936541682034135 4 Q9NUJ1,P50897 2 +Protein depalmitoylation 0.7365899773859024 1.4235129522906904 0.1545875100878557 1.0 0.5936541682034135 4 Q9NUJ1,P50897 2 +Mitochondrial acetyl coa biosynthetic process from pyruvate 0.7361669621479312 1.4216566029234463 0.1551259641586224 1.0 0.594327527352094 4 P09622,P11177 2 +Fatty acid elongation 0.8798384382362776 1.4209959215092631 0.1553179451266433 1.0 0.594327527352094 3 Q9P035,Q9NZ01 2 +Lipid storage 0.4840791030758782 1.4207318797109938 0.1553947208859021 1.0 0.594327527352094 16 P04062,P17900,O95674,Q14534,Q9H6V9,Q8WTV0 6 +Positive regulation of anion transport 0.6335743833254726 1.4191955596342076 0.155842010164068 1.0 0.5944914216211548 6 P08183,Q15041 2 +Peptide catabolic process 0.5594627028714317 1.4077865978439903 0.1591942700573625 1.0 0.599742012242818 10 Q9NZ08,P42892,O14773 3 +Autophagosome organization 0.4157631858564934 1.406653225086645 0.1595302421058351 1.0 0.599742012242818 27 P04062,Q96GC9,P62820,Q9H0U4,O75396,P16615,O95219,O95140,Q86Y82,P53365,Q9Y371,Q9UHD9 12 +Calcium ion transmembrane transport 0.3925491549997988 1.4060858817784108 0.1596986241722984 1.0 0.599742012242818 40 Q13586,P20020,P21796,O95202,Q8IYU8,Q4KMQ2,Q9UJZ1,Q9HC07,P16615,Q8WWC4,Q96AQ8,P62942 12 +Ubiquitin dependent erad pathway 0.3984825043067642 1.402592671073515 0.1607383385369269 1.0 0.6007536133518775 34 Q6NTF9,P27824,Q9GZP9,P46379,Q9Y385,O76024,Q96A33,Q9UHD9,Q9UBV2,P51572,O75477,Q9BUN8 12 +Endomembrane system organization 0.40974823653984 1.400931918481021 0.1612344328918333 1.0 0.6022524365387761 164 Q9BSR8,Q12907,Q15363,O95197,Q7Z3D4,P46379,Q9H4A6,P41440,Q53FT3,Q96A33,Q9Y371,Q5J8M3,Q15006,Q00765,Q96CP7,Q9P253,P51790,O75955,O15260,Q9H6H4,O14657,O43681,P57088,Q86XL3,P40616,Q8N5M9,Q12981,Q15629,Q969M3,P49755,Q9NPA0,Q12846,Q9P2W9,Q8NHH9,O75844,Q9BTV4,P16615,Q13190,P61026,Q9NQC3,Q16739,Q9Y3B3,P50402,Q15041,Q4KMQ2,O75396,P62820,Q14108,O15121,Q9UH99,O43760 51 +Myeloid cell activation involved in immune response 0.5316282110165718 1.398725428807172 0.1618953357274757 1.0 0.6036532971357026 11 Q12846,P09601,O95219,Q99584 4 +Regulation of ire1 mediated unfolded protein response 0.6287418498442174 1.3952740621705446 0.1629332106245014 1.0 0.605860137205528 6 Q96HY6,P57088 2 +Vesicle docking involved in exocytosis 0.6081151564901068 1.3949167816091423 0.1630409359164593 1.0 0.605860137205528 8 Q7Z6M1,P61026,Q9P253 3 +Protein import 0.3528180766034313 1.3943880913939544 0.1632004422459567 1.0 0.6060227442134443 86 Q99595,O60830,Q96P70,Q9Y512,O14925,Q53FT3,P13473,P52292,O96008,Q9NS69,O43615,O00505,Q16539,Q96DA6,O95831,Q8NFH5,O14737,O75381,Q06481,Q9Y5Y5,Q3ZCQ8,Q15388,Q13043,Q92973,P40855,Q99623 26 +Regulation of receptor signaling pathway via stat 0.5823824006488576 1.391945626389267 0.1639388638857088 1.0 0.6073407618222022 9 Q9NX40,Q9H490 2 +Regulation of vacuole organization 0.5107075410232487 1.3894999887136283 0.1646807643524888 1.0 0.6090208068727475 13 O75396,Q14108,O95219,Q9UHD9,Q9Y371 5 +Cdp diacylglycerol metabolic process 0.6274371549186084 1.3888099833336875 0.164890538669677 1.0 0.6090854591675827 6 Q9NUQ2,O95674 2 +Decidualization 0.8640646029609744 1.387807466935844 0.1651956804872068 1.0 0.6095018263753378 2 P35613 1 +Positive regulation of nitric oxide synthase activity 0.8706254782838475 1.384223581362347 0.1662900048923443 1.0 0.6128255852198962 3 Q8WTV0 1 +Positive regulation of peptidase activity 0.3926338587177693 1.3820456748128331 0.1669576772189236 1.0 0.6137632250406093 38 Q9BXK5,Q96A26,Q9NZJ7,Q99538,O95831,Q9P0J0,Q96HY6,Q92542,O43464,P49327,O14737,Q9NR28,P51572,P05067,O75915 15 +Synaptic vesicle exocytosis 0.4561995221030021 1.3817667417948112 0.1670433339611701 1.0 0.6137632250406093 18 Q7L0J3,Q12846,P16615,Q4J6C6 4 +Ether biosynthetic process 0.6685752778713364 1.3809026052081306 0.1673089088261465 1.0 0.6137632250406093 5 O00116,P49327,O15228,Q6IAN0 4 +Glycosylceramide catabolic process 0.8694042409962878 1.379348609227724 0.1677872959737296 1.0 0.6137632250406093 3 P06280,P04062 2 +Maintenance of protein localization in endoplasmic reticulum 0.8690676539885462 1.3780049995409445 0.1682017445550208 1.0 0.6137632250406093 3 P24390,O15258 2 +Protein retention in er lumen 0.8690676539885462 1.3780049995409445 0.1682017445550208 1.0 0.6137632250406093 3 P24390,O15258 2 +Maintenance of location 0.3329578761426408 1.3779540903350438 0.1682174630588153 1.0 0.6137632250406093 64 P24390,P35610,O95202,O43292,P04062,Q9H4A6,P35670,P17900,O95674,P10253,P62942,Q14534,Q9H6V9,O15258,P52789,Q8WTV0 16 +Cholesterol storage 0.8688051435813275 1.3769570907714377 0.1685255145859288 1.0 0.6137632250406093 3 Q8WTV0 1 +External encapsulating structure organization 0.4261266995767319 1.371561224370227 0.1702000718132486 1.0 0.6162783126144805 22 Q96AY3,Q53GQ0,Q92791,P41440,P13674,O75718,O75955 7 +Regulation of amyloid fibril formation 0.6228657999885148 1.3661429323142775 0.1718941052882261 1.0 0.6184404000131648 6 Q9UHV9,P61758,P05067,P10909 4 +Activation of cysteine type endopeptidase activity involved in apoptotic process 0.51684285179413 1.3652140072016978 0.1721857971455294 1.0 0.6184404000131648 12 Q9NZJ7,Q9NR28,Q96A26 3 +Regulation of erad pathway 0.6126031843388835 1.365147775753709 0.1722066086224503 1.0 0.6184404000131648 7 P51572,Q4ZIN3,P46379 3 +Regulation of mitochondrial membrane permeability involved in apoptotic process 0.5767580646409929 1.361228215259746 0.1734415802174844 1.0 0.6214662956322196 9 P45880 1 +Mitochondrial outer membrane permeabilization 0.601018853324587 1.3580225966366126 0.1744565141084555 1.0 0.6245792998448847 8 P45880 1 +Regulation of phospholipase activity 0.5761243930772492 1.3577636821407546 0.1745386824128245 1.0 0.6245792998448847 9 P18085,P04083,P40616,P50897,P35232 5 +Regulation of hormone biosynthetic process 0.8566621803499356 1.3563182427399334 0.1749979335828051 1.0 0.6245792998448847 2 P05023 1 +Regulation of steroid hormone biosynthetic process 0.8566621803499356 1.3563182427399334 0.1749979335828051 1.0 0.6245792998448847 2 P05023 1 +Regulation of lymphocyte mediated immunity 0.4410093875584577 1.3562972862510672 0.1750045985937838 1.0 0.6245792998448847 19 Q96FV9,Q9NQT5,P01889,P11279,O15400,Q9NUQ9,P04439 7 +Cerebellar cortex development 0.5153719066873024 1.35600019501575 0.1750991060022912 1.0 0.6245792998448847 12 O14949,P54802,P04062 3 +Protein localization to membrane raft 0.7210264157992735 1.3551393823886926 0.1753731533259268 1.0 0.6247877710546319 4 P41440,O75955 2 +Negative regulation of glial cell proliferation 0.8563257065948922 1.3548874316527029 0.1754534245787198 1.0 0.6247877710546319 2 Q96G23 1 +Cellular response to topologically incorrect protein 0.3941549099094182 1.3533319681280664 0.175949600755362 1.0 0.6255560034168935 33 Q15363,P57088,Q6NTF9,Q9Y4P3,Q9GZP9,P46379,O76024,Q9BUN8 8 +Golgi vesicle budding 0.6200492110002896 1.3521631578547726 0.1763231266605169 1.0 0.6255560034168935 6 Q15363,P49755,Q9H4A6 3 +Negative regulation of intracellular estrogen receptor signaling pathway 0.6623057801707959 1.3514295465232642 0.1765578743661255 1.0 0.6255560034168935 5 Q9NZN8,Q9P253,Q99623 3 +Regulation of toll like receptor signaling pathway 0.5746918090781965 1.3499284760517676 0.1770389264800576 1.0 0.6257244998472102 9 Q06481,Q9NQC3,P41440,O75955 4 +Positive regulation of t cell mediated immunity 0.6195612741073117 1.3497403201397749 0.1770992941161875 1.0 0.6257244998472102 6 Q9NUQ9,P01889,P04439 3 +Positive regulation of glycoprotein metabolic process 0.5991470246524272 1.3482769697803605 0.1775693165433272 1.0 0.6267115149742344 8 P62820,Q9H0U4,P35610,Q92542 4 +Positive regulation of immune effector process 0.3920794989309047 1.347332119609396 0.1778732918585119 1.0 0.6267115149742344 35 Q06481,Q9NQT5,P01889,P11279,Q12846,O15400,P14174,P09601,O95219,Q9NUQ9,P02786,Q9NRA0,P04083,P35232,P04439 15 +Pattern recognition receptor signaling pathway 0.4056826495320736 1.3462168869535445 0.1782325805537281 1.0 0.6272564398147372 28 Q06481,Q86UT6,O43657,P41440,P51812,Q9NQC3,Q9NUD5,P35232,Q07021,Q96J02,O75955 11 +Phosphatidylinositol metabolic process 0.4205865025082308 1.3456845748919644 0.1784042630589535 1.0 0.6272564398147372 23 Q9H490,O43292,Q92604,Q9NX62,Q9NTJ5,O14735,Q10713,Q9UBF8,Q96N66 9 +Epithelial cell differentiation involved in prostate gland development 0.8608139686636207 1.3450573534531434 0.1786067138389506 1.0 0.6272564398147372 3 P07602 1 +Vesicle fusion with golgi apparatus 0.6608200607899817 1.3444400947178587 0.1788061157367013 1.0 0.6272564398147372 5 Q13190,Q969M3,O75396 3 +Cellular response to oxygen levels 0.405351001089693 1.3431812862663668 0.1792132797126913 1.0 0.6279403357189709 28 Q96A26,Q9Y487,Q15904,Q9Y4P3,P09601,Q8N511,P49327 7 +Lipid biosynthetic process 0.3912961766757861 1.3386335619486285 0.180689994574924 1.0 0.6305839133357276 143 Q8NBX0,Q9NUQ2,O15269,Q53H12,P35610,O75477,Q96G23,O95470,O43292,Q92604,Q8NCC3,Q15800,Q53GQ0,Q9H7Z7,O95864,Q14849,O14735,Q9NZ01,Q10713,P05023,Q8WUK0,P04062,Q9H490,P16435,P30536,Q9NX62,Q9NTJ5,Q9NRA0,Q92643,Q14534,Q14739,Q16850,Q9UBM7,O00116,Q9UG56,Q15392,Q99805,O00767,P37268,Q8NBQ5,P14174,P49327,Q9BY49,Q9UBF8,Q13510,Q16739,Q86YN1,P27544,Q8NF37,Q6Y1H2,O15121,Q06136,P04083,O95674,Q9P035,Q8WTV0,Q96N66 57 +Magnesium ion homeostasis 0.8512786002691802 1.3334316864477052 0.1823901797637956 1.0 0.6328596023152535 2 Q8NE01 1 +Endochondral bone morphogenesis 0.6584579034351852 1.3333237901069912 0.1824255698421817 1.0 0.6328596023152535 5 Q9NX62,O75844 2 +Sodium ion transmembrane transport 0.4608608557793562 1.3321899560058854 0.1827977762000268 1.0 0.6328596023152535 17 Q9H2J7,Q4KMQ2,Q8N668,P27105,Q9Y6M7,P05023,Q6P4Q7 7 +Organic hydroxy compound biosynthetic process 0.3635964677471381 1.3288300273384814 0.1839040532118498 1.0 0.6328596023152535 52 O15269,Q13510,P37268,P04062,Q15800,P16435,P35270,Q14534,Q14739,Q16850,P00374,Q15392,O75477 13 +Positive regulation of chemokine production 0.6052827743707359 1.3279227210694662 0.1842036378103628 1.0 0.6328596023152535 7 P09601,P14174 2 +Chemokine production 0.6052827743707359 1.3279227210694662 0.1842036378103628 1.0 0.6328596023152535 7 P09601,P14174 2 +Cell volume homeostasis 0.714753688475668 1.327545848471618 0.1843281840039583 1.0 0.6328596023152535 4 Q4KMQ2 1 +Cardiolipin metabolic process 0.6150675520623767 1.3274131491008352 0.1843720523905618 1.0 0.6328596023152535 6 P40939,Q9UJZ1,Q8WUK0,Q96DA6 4 +Localization within membrane 0.4132737871351102 1.326919412486428 0.184535342052768 1.0 0.6328596023152535 179 Q15363,Q53H12,Q9Y512,P49354,P46379,O60725,Q9H4A6,P41440,Q96A33,Q9Y371,Q5J8M3,Q15006,Q9Y5J9,Q86YV9,O75955,Q9NS69,O43681,Q9Y5L4,Q9BTX1,Q9NZJ7,Q8NBU5,Q9HD20,P35613,Q15436,P07602,Q99442,P57105,Q8WWC4,Q15629,O14737,Q8N8Q8,P43307,Q9BXS4,Q15070,Q92544,Q9HD45,Q9NPA0,Q12846,O15400,Q9Y5J7,Q99805,Q9P0J0,P27105,Q8N2H4,P61026,Q9Y5Y5,O43805,Q9UHB9,Q9UNK0,Q15041,O15118,Q15904,O95219,Q9Y5J6,P40855,O15258,O00264,Q4J6C6 58 +Xenobiotic transport across blood brain barrier 0.8495962314939458 1.326282689422765 0.1847460785018166 1.0 0.6328596023152535 2 P33527 1 +Sphingolipid translocation 0.8495962314939458 1.326282689422765 0.1847460785018166 1.0 0.6328596023152535 2 P33527 1 +Xenobiotic export 0.8495962314939436 1.3262826894227555 0.1847460785018198 1.0 0.6328596023152535 2 P35670 1 +Import into cell 0.4370554032557254 1.325239902049212 0.1850915947771882 1.0 0.6328596023152535 19 Q15041,P31751,Q15043,O95573,P54709,O75915,P41440,Q15758,P05023,O75955 10 +Protein processing involved in protein targeting to mitochondrion 0.8556223899313391 1.3243353171665746 0.1853917061693857 1.0 0.6328596023152535 3 Q99797 1 +Negative regulation of mrna splicing via spliceosome 0.509702125029617 1.3204350971851968 0.1866897920252732 1.0 0.6331262486510203 12 P61978,O75494,P38159,Q07021,P26368,P22626 6 +Negative regulation of neuron apoptotic process 0.4089947095870471 1.3176292814384682 0.1876277784968705 1.0 0.6333836083845188 26 P04062,P09601,Q01105,P50897 4 +Leukotriene biosynthetic process 0.8538564948036266 1.3172875899427647 0.1877422434347451 1.0 0.6333836083845188 3 Q99735 1 +Adenylate cyclase inhibiting g protein coupled receptor signaling pathway 0.6031514036195718 1.3170707208874313 0.1878149202137331 1.0 0.6333836083845188 7 P07602 1 +Cartilage development 0.4794646901528886 1.316345636573739 0.188058059966502 1.0 0.6333836083845188 15 Q9NX62,O75844,Q16539,Q15043 4 +Regulation of body fluid levels 0.3797253455982876 1.3163236365332422 0.1880654407847324 1.0 0.6333836083845188 43 Q13505,Q16539,Q4KMQ2,P04062,P35670,O76024,P00403,Q9BWH2,P38435,P52789,Q16739 11 +Magnesium ion transport 0.8515651295859894 1.3081435024641863 0.1908246406398119 1.0 0.6389397983367912 3 Q9H0U3,Q8IUH4 2 +Interleukin 12 production 0.600995619388994 1.3060884578365912 0.1915224776198569 1.0 0.6399234682076972 7 P01889,Q16539,Q08722 3 +Ire1 mediated unfolded protein response 0.6009368626399407 1.305789049932833 0.1916243048449919 1.0 0.6399261840764491 7 Q96HY6,P57088 2 +Exocytosis 0.3361187359843673 1.3039261770097854 0.1922587540384457 1.0 0.640091024477223 74 Q7Z6M1,P51151,Q13636,Q9P253,Q7L0J3,Q9BRK5,Q9NRA0,Q8N5M9,P49755,P11279,Q12846,Q99584,Q8TBQ9,P16615,P61026,O15498,P09601,O95219,P04083,O43760,Q4J6C6 21 +Regulation of hormone secretion 0.3974770572332484 1.3027317428347347 0.192666360991021 1.0 0.640091024477223 29 Q16836,Q8N183,Q12846,P00367,P53985,P51809,O95219,Q9BRT2,P40939,P04083,Q8N5M9,O95563,Q16822,P22466 14 +Mitochondrial outer membrane permeabilization involved in programmed cell death 0.5658852074373506 1.3016839022666429 0.1930244647579839 1.0 0.640091024477223 9 P45880 1 +Neurotransmitter catabolic process 0.8435397039031034 1.300560246635324 0.1934090217351971 1.0 0.640091024477223 2 P21964 1 +Lipopolysaccharide mediated signaling pathway 0.6095674963247033 1.300054148826066 0.1935824110082562 1.0 0.640091024477223 6 Q86UE4,Q16539,Q8WTV0 3 +Detection of biotic stimulus 0.6510557707477505 1.2984622730324156 0.1941285323097452 1.0 0.6408950419549162 5 P30536,P04439,Q8WTV0 3 +Cobalamin metabolic process 0.7072496700964384 1.2945165125647904 0.1954870693559021 1.0 0.6415609440110982 4 P33527 1 +Lipid catabolic process 0.3350980613488465 1.2900514521071258 0.197032794289528 1.0 0.6430575406228815 74 P35610,P17050,O95470,Q8NCC3,Q8N2K0,P50897,Q99735,P04062,P17900,Q8NHP8,Q8NBQ5,P23786,Q8N2A8,O15254,P06865,P40939,P06280,Q9H6V9,Q13510,Q9BWD1,Q15067,O43808,A1L0T0,Q8IY17,Q8WTV0 25 +Carbohydrate transport 0.4550967733055329 1.289879715515171 0.1970924246534009 1.0 0.6430575406228815 17 Q06481,Q16539,L0R6Q1,Q96AA3,O75298,P52789 6 +Regulation of pattern recognition receptor signaling pathway 0.4309991194154186 1.277551907523194 0.2014074669673036 1.0 0.64899099859505 19 Q06481,Q86UT6,O43657,P41440,Q9NQC3,Q9NUD5,O75955 7 +Cell recognition 0.4307654403157984 1.2757091736610309 0.2020583445050363 1.0 0.6494366374629149 19 P45880,P35613,Q9NQC3 3 +Regulation of amyloid precursor protein catabolic process 0.5024305000856069 1.2747121523912837 0.2024111439176574 1.0 0.6494773377273536 12 Q96P70,O95197,P10909,Q9NQC3,P62942,P49755,O75298 7 +Iron ion transport 0.5609358417438369 1.2745146167817054 0.2024810958187093 1.0 0.6494773377273536 9 P02786,O75027,Q15043,O15173 4 +Multicellular organism aging 0.5601836248748537 1.270382114851878 0.2039485509301091 1.0 0.6528620869844574 9 P04062 1 +Water homeostasis 0.5836824571463757 1.2675608784924035 0.2049548101720879 1.0 0.654139894700524 8 Q16739,P04062 2 +Amyloid beta metabolic process 0.5096275307725955 1.2646317407476455 0.2060033693653586 1.0 0.6552840086675329 11 O95197,Q92542,Q9NQC3,P49755,O75298 5 +Sodium ion homeostasis 0.6438517654441489 1.2645000956275578 0.2060505864119981 1.0 0.6552840086675329 5 P05023,P54709,Q9Y5X3 3 +Mitochondrial fission 0.4910346179340935 1.2621971068642004 0.2068778695099529 1.0 0.6552840086675329 13 Q9NUQ9,Q9UDX5 2 +Mitochondrial gene expression 0.3600953649249584 1.2619624237433142 0.2069623079006419 1.0 0.6552840086675329 51 P34897,Q6PI48,Q5T160,Q9Y2R0,Q9BSK2,Q9NWS8,O00411,Q567V2,P49411,Q9BRT2,Q9NVS2,Q5JTZ9,Q9BW92,Q07021,Q00059 15 +Neuromuscular junction development 0.5820757010455118 1.2591558787428263 0.2079740344674194 1.0 0.6558716670794618 8 P49354,O15258 2 +Positive regulation of cell migration involved in sprouting angiogenesis 0.8327725437415967 1.254896298407268 0.2095164079229705 1.0 0.6571634303963264 2 P09601 1 +Regulation of cell migration involved in sprouting angiogenesis 0.8327725437415967 1.254896298407268 0.2095164079229705 1.0 0.6571634303963264 2 P09601 1 +Negative regulation of lipase activity 0.8327725437415884 1.2548962984072332 0.2095164079229832 1.0 0.6571634303963264 2 P16435 1 +Arachidonic acid secretion 0.8327725437415876 1.254896298407229 0.2095164079229847 1.0 0.6571634303963264 2 P14174 1 +Positive regulation of fatty acid metabolic process 0.6979797979798005 1.253695907902395 0.2099525558762389 1.0 0.6571634303963264 4 P50416,P04083,Q92604 3 +Regulation of long term synaptic potentiation 0.5997590770285278 1.2511871232299914 0.2108662150823781 1.0 0.6571634303963264 6 Q99538,P05067,Q92542 3 +Ubiquinone metabolic process 0.6974075871649388 1.251175753218435 0.2108703623946364 1.0 0.6571634303963264 4 O75208 1 +Atp metabolic process 0.3579041421987494 1.249876505024978 0.2113446633042293 1.0 0.6571634303963264 106 P13073,Q9UJS0,P14406,P09622,Q9H3K2,Q9BRT2,P00403,O96000,Q9UDW1,O75964,O95139,P00846,Q9Y6M9,O43676,P51970,P30536,O75438,Q9NRA0,O14949,P24539,O43674,Q9BRR6,P05067,P52789,P03886,Q9BSK2,Q9UJZ1,P56385,P08574,Q9NTK5,O95168,O75208,P22695 33 +Diencephalon development 0.6393878353475854 1.2434422208865563 0.2137049200637191 1.0 0.6597726339296701 5 O14949 1 +Cellular lipid catabolic process 0.3295204421896908 1.2434281730228267 0.2137100938948197 1.0 0.6597726339296701 62 P35610,P17050,O95470,Q8NCC3,Q8N2K0,P50897,Q99735,P04062,P17900,Q8NHP8,P23786,O15254,P06865,P40939,P06280,Q13510,Q9BWD1,Q15067,O43808,A1L0T0,Q8IY17,Q8WTV0 22 +Cd40 signaling pathway 0.6952861952862014 1.2418324655515034 0.214298381599816 1.0 0.6607368744105397 4 P35232,Q9BXW9,Q99623 3 +Alpha beta t cell proliferation 0.8294078061911164 1.2406466059104693 0.2147363269417765 1.0 0.6613294269208336 2 Q96J02 1 +Prostate gland growth 0.8334567306785606 1.2359311777730848 0.2164841467141913 1.0 0.6642801740124776 3 P07602 1 +Positive regulation of blood circulation 0.8331146125040754 1.2345681223922758 0.2169912790066743 1.0 0.6642801740124776 3 P05023 1 +Antiviral innate immune response 0.6936026936026982 1.2344176941861895 0.2170472989754213 1.0 0.6642801740124776 4 P35232,Q99623,Q9NVI7 3 +Icosanoid transport 0.8330528441602105 1.2343220332419926 0.2170829288434572 1.0 0.6642801740124776 3 P14174,P33527 2 +Glycerol ether metabolic process 0.5960472787737282 1.2326721684796496 0.2176980995241648 1.0 0.6652761507407546 6 O00116,P49327,O15228,Q6IAN0 4 +Regulation of skeletal muscle cell differentiation 0.6930180509104216 1.2318427095351512 0.218007845670231 1.0 0.665715291582829 4 Q9BRT2 1 +Pore complex assembly 0.4949695749025631 1.2276832939485045 0.219565880148242 1.0 0.6670434205618241 12 Q9NQC3,Q9BTX1 2 +Regulation of response to endoplasmic reticulum stress 0.4041550693764042 1.2263785278526107 0.2200562624634001 1.0 0.6670434205618241 24 P57088,O60313,Q96HY6,P10909,P46379,O95881,O76024,Q9UHD9,P51572,Q4ZIN3 10 +Maintenance of protein localization in organelle 0.4754384631559735 1.224840111315167 0.2206354686595175 1.0 0.6670434205618241 14 P24390,P52789,O15258,O43292 4 +Embryonic hemopoiesis 0.6913080402140307 1.2243112389932074 0.2208348387615164 1.0 0.6670434205618241 4 Q13043,Q03164 2 +Antigen processing and presentation of exogenous peptide antigen via mhc class i 0.8296869740827906 1.220915150891783 0.2221181473576692 1.0 0.6677403463284358 3 Q03518,Q9UIQ6 2 +Positive regulation of mononuclear cell migration 0.5511782725991107 1.220847982866664 0.2221435824565254 1.0 0.6677403463284358 9 Q4KMQ2,Q8NHP6,Q07021,P05067,Q08722 5 +Phosphatidylglycerol acyl chain remodeling 0.8246971736204669 1.2207158336573654 0.2221936306330294 1.0 0.6677403463284358 2 Q8NF37 1 +Phosphatidylinositol acyl chain remodeling 0.8246971736204631 1.2207158336573494 0.2221936306330354 1.0 0.6677403463284358 2 Q96N66 1 +Positive regulation of fatty acid biosynthetic process 0.8246971736204567 1.220715833657323 0.2221936306330454 1.0 0.6677403463284358 2 P04083 1 +T cell differentiation in thymus 0.5745317163416142 1.2196525494991328 0.2225966165434338 1.0 0.6681278548506675 8 P04062 1 +Phosphatidylcholine catabolic process 0.824360699865416 1.2192930992635014 0.2227329668566229 1.0 0.6681278548506675 2 Q8WTV0 1 +Negative regulation of exocytosis 0.5839329475228174 1.2189792875533747 0.2228520539707856 1.0 0.6681278548506675 7 P09601 1 +Neutral lipid biosynthetic process 0.5837210541542425 1.2178957113552462 0.2232636061627166 1.0 0.6682503763356825 7 Q92604,Q8NCC3,Q8WTV0 3 +Reactive oxygen species biosynthetic process 0.5264764836232682 1.217320518581244 0.2234822904626434 1.0 0.6682503763356825 10 Q9BSK2,Q15067,P00403,O75027,P51790 5 +Myeloid leukocyte differentiation 0.4003453359071578 1.2158099701853295 0.2240573199006681 1.0 0.6689868371897384 25 Q16539,P04062,P49327,Q8N5M9,Q14739 5 +Regulation of stem cell population maintenance 0.6331216512983078 1.2138696170637306 0.2247975167155194 1.0 0.6689868371897384 5 Q9NZN8,Q9Y6J9 2 +Peptidyl asparagine modification 0.5496998221354253 1.21270580720778 0.2252423187864258 1.0 0.6689868371897384 9 Q8TCJ2,P46977,P04843,Q9H0U3,Q9Y385 5 +Pteridine containing compound metabolic process 0.4444481668904081 1.2114489416795065 0.2257233918327232 1.0 0.6689868371897384 17 P34897,P31939,Q9H2D1,P41440,P35270,P00374 6 +Folic acid transport 0.8223418573351385 1.2107593183151255 0.2259876608659738 1.0 0.6689868371897384 2 Q9H2D1 1 +Folate transmembrane transport 0.8223418573351385 1.2107593183151255 0.2259876608659738 1.0 0.6689868371897384 2 Q9H2D1 1 +Positive regulation of toll like receptor 3 signaling pathway 0.8223418573351293 1.210759318315086 0.2259876608659889 1.0 0.6689868371897384 2 O75955 1 +Regulation of synaptic transmission dopaminergic 0.8223418573351293 1.210759318315086 0.2259876608659889 1.0 0.6689868371897384 2 O75955 1 +Positive regulation of heterotypic cell cell adhesion 0.8223418573351293 1.210759318315086 0.2259876608659889 1.0 0.6689868371897384 2 O75955 1 +Reactive oxygen species metabolic process 0.3745291634068166 1.2078378361047886 0.2271096446801728 1.0 0.6719942078696379 39 Q9BSK2,P42785,Q16539,P18085,Q9P0J0,P30536,Q15067,P00374,P00403,O75027,Q13423,P52789,P51790 13 +Adaptive immune response 0.3764390093961507 1.2074200493014031 0.2272704181061455 1.0 0.6721559751178489 37 Q96FV9,Q9NQT5,P01889,O15400,Q9NZ08,Q9NUQ9,P02786,P04083,P35232,Q07021,P10321,P04439,Q03518 13 +Positive regulation of leukocyte degranulation 0.5907562682897256 1.206262312955555 0.2277163640783865 1.0 0.6725329447256779 6 O95219,Q12846,Q9NRA0,P11279 4 +Negative regulation of endoplasmic reticulum unfolded protein response 0.6307560742173018 1.2027026307497768 0.2290914155243884 1.0 0.6733117259268855 5 O76024,Q96HY6 2 +Neural retina development 0.5892638965482374 1.1988099092433648 0.2306018685841491 1.0 0.6756224204622528 6 Q8NBN7,P54802 2 +Pirna metabolic process 0.8193135935397142 1.1979674035017016 0.23092970719645 1.0 0.6756224204622528 2 Q8N2A8 1 +Release of cytochrome c from mitochondria 0.461803868742956 1.1943123485975111 0.2323558089856159 1.0 0.6758424375483857 15 Q96A26,O60313,Q9H3K2,O14737,Q3ZCQ8 5 +Cobalamin transport 0.8183041722745668 1.1937058635008355 0.2325930460556384 1.0 0.6758424375483857 2 P33527 1 +Regulation of cell killing 0.5695191544839427 1.193371616009964 0.2327238661425503 1.0 0.6758424375483857 8 Q9NUQ9,P11279,P01889,P04439 4 +Amyloid beta formation 0.5460907738355993 1.192819426384103 0.2329401002612945 1.0 0.6758424375483857 9 O95197,Q92542,Q9NQC3,P49755,O75298 5 +Negative regulation of cell volume 0.8176312247644717 1.1908655333989968 0.2337063771131329 1.0 0.6758424375483857 2 Q4KMQ2 1 +Circulatory system process 0.337110710904518 1.190631731611097 0.2337981889463569 1.0 0.6758424375483857 58 P42785,Q9Y5X3,P41440,P05023,P20020,Q9UIQ6,Q6PI78,Q9HB40,P33527,P08183,P42892,P53985,P16615,O75844,P10253,Q9NZ08,Q16625,P09601,P02786 19 +Regulation of organic acid transport 0.5217623968191692 1.1899521622200944 0.2340651947901397 1.0 0.6758424375483857 10 Q15041,P14174,P31751,Q7L0J3,Q9Y3D6,O75915 6 +Regulation of calcium ion import 0.6831111181434479 1.1882133277248694 0.2347493741804327 1.0 0.6758424375483857 4 P21796 1 +Positive regulation of cyclase activity 0.8169582772543793 1.1880257690844456 0.2348232574317723 1.0 0.6758424375483857 2 Q16539 1 +Enamel mineralization 0.8169582772543752 1.188025769084428 0.2348232574317792 1.0 0.6758424375483857 2 Q6P4Q7 1 +Tooth mineralization 0.8169582772543752 1.188025769084428 0.2348232574317792 1.0 0.6758424375483857 2 Q6P4Q7 1 +Amelogenesis 0.8169582772543752 1.188025769084428 0.2348232574317792 1.0 0.6758424375483857 2 Q6P4Q7 1 +Vasoconstriction 0.8166218034993313 1.1866061013952705 0.2353830281220521 1.0 0.6758424375483857 2 P42892 1 +Regulation of vasoconstriction 0.8166218034993313 1.1866061013952705 0.2353830281220521 1.0 0.6758424375483857 2 P42892 1 +Positive regulation of lymphocyte mediated immunity 0.4606802884774515 1.18652403868653 0.2354154140501498 1.0 0.6758424375483857 15 P11279,P01889,Q9NQT5,O15400,Q9NUQ9,P04439 6 +T cell tolerance induction 0.8162853297442801 1.1851865779150657 0.2359436855839709 1.0 0.6758559914700099 2 Q96J02 1 +Lymphocyte anergy 0.8162853297442801 1.1851865779150657 0.2359436855839709 1.0 0.6758559914700099 2 Q96J02 1 +Detection of other organism 0.8162853297442791 1.1851865779150603 0.2359436855839729 1.0 0.6758559914700099 2 P04439 1 +Protection from natural killer cell mediated cytotoxicity 0.8162853297442791 1.1851865779150603 0.2359436855839729 1.0 0.6758559914700099 2 P04439 1 +Regulation of exit from mitosis 0.6821039390343608 1.1837787117084373 0.2365006713145276 1.0 0.6767081087522732 4 Q99623 1 +Monocarboxylic acid transport 0.5767434119486889 1.1821938604952462 0.2371287881687178 1.0 0.6770142635752155 7 P04083,P53985,P14174,P28288 4 +Dna methylation involved in gamete generation 0.8195893638505425 1.1807348186817073 0.2377080849354551 1.0 0.6770142635752155 3 Q8N2A8,Q8NB78 2 +Lipid homeostasis 0.3907125615546693 1.180248063005123 0.2379015681837668 1.0 0.6770142635752155 27 O15260,P35610,O15118,Q86YV9,Q15067,Q9BWH2,Q9NQC3,Q8WTV0,Q96CP7,Q5BJF2,Q9Y6C9 11 +Aminophospholipid transport 0.8149394347241015 1.1795099446323802 0.2381951791458501 1.0 0.6770142635752155 2 Q14108 1 +Xenobiotic transmembrane transport 0.8149394347240903 1.179509944632333 0.2381951791458689 1.0 0.6770142635752155 2 P41440 1 +Calcium ion export 0.6793665023340001 1.1717271425222 0.2413066220452848 1.0 0.6805609841619272 4 O95202 1 +Regulation of ion transport 0.3255855327717043 1.171705329798633 0.2413153824545859 1.0 0.6805609841619272 73 Q9BVC6,Q8N668,P0CG08,P05023,Q13586,P20020,P21796,Q7L0J3,P30536,O00483,Q9NRA0,Q8TAD4,P08183,P14174,P27105,O75844,O76024,P05067,P22466,O75915,Q15041,O75323,Q4KMQ2,Q96GC9,O95219,P62942,Q99623 27 +Antigen processing and presentation of endogenous peptide antigen via mhc class i via er pathway 0.8165600807808747 1.168694488037818 0.242526743511501 1.0 0.6805609841619272 3 P10321,P04439 2 +Detection of external biotic stimulus 0.8165600807808738 1.1686944880378136 0.2425267435115028 1.0 0.6805609841619272 3 P04439,Q8WTV0 2 +Tetrahydrobiopterin metabolic process 0.8165168828149145 1.1685228427713554 0.2425959306845042 1.0 0.6805609841619272 3 P35270 1 +Amino acid import 0.5641526946755594 1.165210323455953 0.2439338678828386 1.0 0.6805609841619272 8 Q15041,Q96NB2,Q15758,O75915 4 +Negative regulation of protein exit from endoplasmic reticulum 0.8112382234185813 1.1639116658811548 0.2444598114353589 1.0 0.6805609841619272 2 Q9GZP9 1 +Heparan sulfate proteoglycan metabolic process 0.6774246751976102 1.163179669717845 0.2447566132624659 1.0 0.6805609841619272 4 Q99805,Q7LGA3 2 +Heparan sulfate proteoglycan biosynthetic process 0.6774246751976102 1.163179669717845 0.2447566132624659 1.0 0.6805609841619272 4 Q99805,Q7LGA3 2 +Regulation of deacetylase activity 0.8109017496635357 1.1624945772508513 0.2450346261258622 1.0 0.6805609841619272 2 P49354 1 +Histone h2a phosphorylation 0.6770425266077456 1.1614976969888835 0.2454395592042639 1.0 0.680761649544226 4 O75844 1 +Chromatin remodeling at centromere 0.6766751878944566 1.1598809593544528 0.2460972759879836 1.0 0.6816905305570075 4 P49321 1 +Modified amino acid transport 0.6211927028441301 1.15754987659578 0.2470477740822199 1.0 0.6819654391818791 5 P41440,Q9H2D1,P33527 3 +Granzyme mediated programmed cell death signaling pathway 0.8092193808882955 1.1554115575111028 0.2479219312734113 1.0 0.6819654391818791 2 P11279 1 +Regulation of heart contraction 0.4023221933014407 1.1548536500219089 0.2481503627185881 1.0 0.6819654391818791 21 P05023,O75844,P16615,Q6PI78 4 +Positive regulation of fat cell differentiation 0.6206063106223059 1.1547811833138752 0.2481800445247621 1.0 0.6819654391818791 5 Q16539 1 +Terpenoid metabolic process 0.4037339844185254 1.1518556954150183 0.2493803766908913 1.0 0.6819654391818791 20 Q8NBN7,Q6NUM9,P37268,Q9HB40,Q9BY49,P51648 6 +Peptidyl lysine hydroxylation 0.6199821019317178 1.15183396190986 0.2493893091387977 1.0 0.6819654391818791 5 Q92791 1 +Regulation of retrograde protein transport er to cytosol 0.8115112756647495 1.1486437213227323 0.2507029209105031 1.0 0.6824986746242411 3 P51572,Q9GZP9 2 +Hippo signaling 0.6192762705382506 1.1485013956150267 0.2507616372082988 1.0 0.6824986746242411 5 Q16539 1 +Skin development 0.3731255260994956 1.1466640774000474 0.2515204824955013 1.0 0.6832685491462267 33 Q13510,O75844,Q15392,P04062 4 +Glycosylceramide biosynthetic process 0.8068640646029717 1.1455022928922636 0.2520011461690539 1.0 0.6836947584500884 2 Q16739 1 +Vacuolar proton transporting v type atpase complex assembly 0.8065275908479261 1.144087363856419 0.2525874075491194 1.0 0.6838210371041332 2 Q8N511 1 +Proton transporting v type atpase complex assembly 0.8065275908479261 1.144087363856419 0.2525874075491194 1.0 0.6838210371041332 2 Q8N511 1 +Double strand break repair via break induced replication 0.5370825276782248 1.143126110581221 0.2529862348137963 1.0 0.6842409361951672 9 Q9Y248 1 +Regulation of fc gamma receptor signaling pathway involved in phagocytosis 0.8061911170928767 1.14267260784659 0.2531745468731525 1.0 0.6842409361951672 2 Q08722 1 +Response to dietary excess 0.8061911170928726 1.1426726078465708 0.2531745468731605 1.0 0.6842409361951672 2 Q16539 1 +Protein o linked glycosylation via threonine 0.8088224793503009 1.1379745906204537 0.2551310925742593 1.0 0.6867218674137008 3 Q8N4A0 1 +Glycosphingolipid biosynthetic process 0.8071356445641062 1.1312847081863044 0.2579352784689326 1.0 0.6902072767128109 3 Q99805,Q16739 2 +Response to oxygen levels 0.3527707654182962 1.1311380910114133 0.2579969741524761 1.0 0.6902072767128109 49 Q92544,Q96A26,P00846,O95831,Q9Y487,Q9Y4P3,Q15904,P09601,Q8N511,P02786,P30519,P49327,P61421,P52789,Q99623 15 +Toll like receptor 4 signaling pathway 0.8064624705486348 1.1286157158827528 0.2590599780663085 1.0 0.6910084046526588 3 P41440,O75955 2 +Regulation of toll like receptor 4 signaling pathway 0.8064624705486348 1.1286157158827528 0.2590599780663085 1.0 0.6910084046526588 3 P41440,O75955 2 +Protein localization to extracellular region 0.3264591981507257 1.1247689906353109 0.2606869379727399 1.0 0.6935737100815297 60 Q9H4A6,Q9BRT2,Q86YV9,Q16836,Q96KC8,Q5T9L3,P27824,Q8N5M9,Q16850,Q96PC5,P49755,Q32P28,Q12846,P53985,Q8TBQ9,P40939,P61026,P22466,Q8N183,P04083,Q9UBV2 21 +Glycerophospholipid catabolic process 0.5654202175515862 1.124193847881272 0.2609307988037228 1.0 0.6935737100815297 7 Q8NCC3,Q8IY17,Q8WTV0 3 +Glycerophospholipid biosynthetic process 0.3639433249136421 1.1204705567018884 0.2625132926935796 1.0 0.6938556892147505 41 Q9NUQ2,Q8NF37,O43292,Q9H490,Q9NX62,Q9NTJ5,O14735,O95674,Q10713,Q9UBF8,Q9UG56,Q8WUK0,Q96N66 13 +Positive regulation of monocyte chemotaxis 0.6677087107547424 1.1204365112333394 0.2625277934023355 1.0 0.6938556892147505 4 Q4KMQ2,Q8NHP6 2 +Associative learning 0.5096989564996032 1.1198013851904125 0.262798408875367 1.0 0.6938556892147505 10 P50897 1 +Peripheral nervous system development 0.5096814763317659 1.1196996385683566 0.2628417791230317 1.0 0.6938556892147505 10 P51648 1 +Negative regulation of lipid biosynthetic process 0.5549668213550546 1.1169591621066368 0.2640117866690592 1.0 0.6948729407194543 8 P05023,Q8NF37 2 +Embryonic heart tube development 0.6663432812131516 1.1144336745586303 0.265093183530741 1.0 0.6965430600030049 4 Q15363 1 +Negative regulation of nitric oxide metabolic process 0.8027600134634734 1.113944493692113 0.2653029998092251 1.0 0.696805349830614 3 P06280,P30536 2 +Cell maturation 0.3952739897494665 1.1117151443252915 0.2662606462516208 1.0 0.6980662809099726 22 O75503,P04062,Q9NZJ7,P09622,Q8N2A8,Q15058,Q9Y2W6 7 +Perk mediated unfolded protein response 0.665648663980821 1.111380385206356 0.2664046516311917 1.0 0.6980662809099726 4 Q15363 1 +Integrated stress response signaling 0.665648663980821 1.111380385206356 0.2664046516311917 1.0 0.6980662809099726 4 Q15363 1 +Negative regulation of viral induced cytoplasmic pattern recognition receptor signaling pathway 0.6109983471525486 1.109423826959344 0.2672473882518336 1.0 0.6995918200724652 5 O43657 1 +Interferon gamma production 0.5624681288547638 1.1090640463085997 0.2674025537279623 1.0 0.6997088714856015 7 Q9NUQ9,P04439,Q08722 3 +Microglia differentiation 0.7974427994616544 1.105953006973915 0.2687468599124769 1.0 0.70052202422734 2 P04062 1 +Negative regulation of amyloid fibril formation 0.6099696867632188 1.1045691234640271 0.269346336318363 1.0 0.7005577866197205 5 Q9UHV9,P61758,O15212,P10909 4 +Transport of virus 0.6097848609236687 1.1036968892778745 0.2697246454826922 1.0 0.7005577866197205 5 O00505 1 +Intracellular transport of virus 0.6097848609236687 1.1036968892778745 0.2697246454826922 1.0 0.7005577866197205 5 O00505 1 +Regulation of glucocorticoid metabolic process 0.7967698519515547 1.1031338118725638 0.2699690593676727 1.0 0.7005577866197205 2 P05023 1 +Fatty acid alpha oxidation 0.7996887163176278 1.1017854051991336 0.2705549768719266 1.0 0.701300800823682 3 A1L0T0 1 +Negative regulation of insulin secretion involved in cellular response to glucose stimulus 0.7957604306864188 1.0989065445600494 0.2718088317300187 1.0 0.7042572388587601 2 Q8N5M9 1 +Negative regulation of defense response to virus 0.5603727803291607 1.0983239170880468 0.2720630717890913 1.0 0.7045121154931494 7 Q86UT6,Q96J02,O43657 3 +Regulation of production of molecular mediator of immune response 0.3843328058226156 1.0970503814349877 0.2726193688381741 1.0 0.7046670076081838 26 Q96FV9,Q9NQT5,Q12846,P14174,P09601,P02786,Q9NRA0,P35232,P04439 9 +Mammary gland development 0.4288755491964031 1.096252962380894 0.2729680878722151 1.0 0.7046670076081838 17 Q13505,P49327,P00403,Q9NQC3,P52789 5 +Sodium ion transport 0.3969493839980773 1.0959134977195726 0.2731166315848257 1.0 0.7047632835396622 20 Q9H2J7,Q4KMQ2,Q8N668,P27105,Q9Y6M7,P05023,Q6P4Q7 7 +Positive regulation of leukocyte mediated immunity 0.3949037660632135 1.0928639193431056 0.2744535519648323 1.0 0.7067736795517126 21 Q9NQT5,P01889,P11279,Q12846,O15400,Q9NUQ9,P04439 7 +Homologous chromosome segregation 0.5046694717443658 1.0905177646403987 0.2754851323030465 1.0 0.7070470466837779 10 Q9BXW9,Q9BTX1,Q92791,P46379,P53350 5 +Aspartate transmembrane transport 0.7967014473241237 1.0899692904682667 0.275726671886296 1.0 0.7070470466837779 3 Q9H936,Q9UJS0 2 +Eye photoreceptor cell differentiation 0.6068065225432309 1.0896433604701443 0.2758702748598058 1.0 0.7070470466837779 5 Q8NBN7 1 +Establishment of pigment granule localization 0.7930686406460274 1.0876429862557662 0.2767527461430088 1.0 0.7089480981868018 2 Q13561 1 +Maintenance of protein location in mitochondrion 0.7954987264721571 1.085214944685996 0.2778264666613215 1.0 0.7108362949513214 3 P52789 1 +Photoreceptor cell differentiation 0.5646229635638877 1.07564532523044 0.2820859083296931 1.0 0.7152651176674858 6 Q8NBN7 1 +Negative regulation of interleukin 6 production 0.7929490317112811 1.075141968797428 0.2823111719662878 1.0 0.7152651176674858 3 P04062 1 +Acute phase response 0.790040376850618 1.074987957696364 0.2823801198557825 1.0 0.7152651176674858 2 Q9BQE5 1 +Production of sirna involved in rna interference 0.7921180813802084 1.0718609618276125 0.2837824867268148 1.0 0.7170969499060119 3 O75569 1 +Regulation of glial cell proliferation 0.7919797953822223 1.0713150270742022 0.284027805309573 1.0 0.7171447375991014 3 Q96G23 1 +Regulation of myeloid leukocyte mediated immunity 0.5012857490793633 1.0708085327343413 0.2842555294826447 1.0 0.7174337766026114 10 Q12846,Q9NRA0,P09601,O95219 4 +Postsynaptic membrane organization 0.5632752829107486 1.0689076890825595 0.2851112669005018 1.0 0.718162972490926 6 P49354 1 +Heart morphogenesis 0.4045970406022577 1.0683269876363173 0.2853730389027098 1.0 0.7185366460447801 19 Q15363,P10253,Q9NQC3,O75844 4 +L serine transport 0.7883580080753678 1.067965208842696 0.2855362057960042 1.0 0.7186618449414728 2 Q15758 1 +Positive regulation of b cell proliferation 0.7903062941770425 1.0647102755742346 0.2870070586301507 1.0 0.7204454568135621 3 P14174,Q9NPF0 2 +Negative regulation of mitochondrion organization 0.4430704094878513 1.0641833028413143 0.2872456694778016 1.0 0.7205992071326678 15 O60313,Q99536,P30536,Q9H3K2,P10909,P02786,P05141 7 +Regulation of insulin secretion 0.3895502826732784 1.063165960100213 0.2877066962628549 1.0 0.7205992071326678 22 Q16836,Q8N183,Q12846,P00367,P53985,Q9BRT2,P40939,Q8N5M9,O95563,Q16822 10 +Regulation of the force of heart contraction 0.654515433723373 1.0624924469844546 0.2880121850765453 1.0 0.7205992071326678 4 P05023,P16615 2 +Tor signaling 0.4141236839424499 1.0608533015376118 0.2887565745112521 1.0 0.7212435201336362 18 O75844,P04062 2 +Regulation of mammary gland epithelial cell proliferation 0.7860026917900527 1.0581430799994922 0.2899902166182473 1.0 0.7213416081097919 2 Q9NQC3 1 +Activation of protein kinase c activity 0.7860026917900399 1.058143079999438 0.2899902166182719 1.0 0.7213416081097919 2 P35232 1 +Regulation of phospholipase c activity 0.7860026917900399 1.058143079999438 0.2899902166182719 1.0 0.7213416081097919 2 P35232 1 +Activation of phospholipase c activity 0.7860026917900399 1.058143079999438 0.2899902166182719 1.0 0.7213416081097919 2 P35232 1 +Serine transport 0.7886233591383371 1.0580721114145062 0.2900225677860557 1.0 0.7213416081097919 3 Q96NB2,Q15758 2 +Plasma lipoprotein particle clearance 0.4759653019922829 1.0578347911313633 0.2901307683447118 1.0 0.7213416081097919 11 P09601,Q8WTV0 2 +Negative regulation of amyloid precursor protein catabolic process 0.5214870746922162 1.0569668711190596 0.2905267072623307 1.0 0.7216720438757357 9 O95197,Q9NQC3 2 +Chondroitin sulfate proteoglycan metabolic process 0.7849932705249061 1.0539371535258908 0.291911691317962 1.0 0.723099258106193 2 Q9NX62 1 +Positive regulation of nervous system process 0.7873442047128023 1.0530292493156157 0.2923275868488433 1.0 0.7236792742037602 3 P04062 1 +Retina development in camera type eye 0.4588084078341955 1.0520056660297104 0.2927969500703096 1.0 0.7239924585071863 13 Q8NBN7,Q8NF37 2 +Protein localization to vacuole 0.3915441782940668 1.0512759253169952 0.2931318808059384 1.0 0.7245378325812017 20 Q5THJ4,Q96RL7,Q14108,Q9Y371,P13473,Q9NQC3 6 +Regulation of bone mineralization 0.5982053107340641 1.0490842180886355 0.2941393590019274 1.0 0.7265176757285399 5 O75844,Q4KMQ2 2 +Regulation of complement activation 0.7862672500841459 1.0487853301907757 0.294276930689729 1.0 0.7265176757285399 3 P35232,Q07021 2 +Regulation of humoral immune response 0.7862672500841459 1.0487853301907757 0.294276930689729 1.0 0.7265176757285399 3 P35232,Q07021 2 +Hypothalamus development 0.6510901242120082 1.0474737252381934 0.294881144255974 1.0 0.7271592249363936 4 O14949 1 +Glial cell migration 0.4662324289997218 1.0457618134894355 0.2956710157671736 1.0 0.727667443966589 12 Q96N66,Q9NQC3,Q96G23 3 +Phosphate ion transport 0.785323797334299 1.0450688767375276 0.2959911373132775 1.0 0.727667443966589 3 Q9UBX3 1 +Phosphate ion transmembrane transport 0.785323797334299 1.0450688767375276 0.2959911373132775 1.0 0.727667443966589 3 Q9UBX3 1 +Fat soluble vitamin metabolic process 0.558499803510424 1.0450368234714913 0.2960059508291728 1.0 0.727667443966589 6 Q8N0U8,P04062 2 +Response to thyroid hormone 0.558399287793931 1.044534464744098 0.2962381822987885 1.0 0.727673084475698 6 P04062 1 +Cellular extravasation 0.5492180643773227 1.0411448630200884 0.2978083208048889 1.0 0.7306799815255506 7 Q08722 1 +Myeloid leukocyte migration 0.382761388605065 1.0400117897630914 0.2983344232422378 1.0 0.7312992135149596 24 P14174,Q4KMQ2,P35613,P04083,Q8N5M9,Q8NHP6,Q07021,Q08722 8 +Very long chain fatty acid catabolic process 0.7839943321381928 1.0398340686227965 0.2984169980375468 1.0 0.7312992135149596 3 Q15067 1 +Positive regulation of lipase activity 0.5571360642258248 1.0382214648491928 0.2991669616647381 1.0 0.7312992135149596 6 P35232,P18085,P40616 3 +Positive regulation of phospholipase activity 0.5571360642258248 1.0382214648491928 0.2991669616647381 1.0 0.7312992135149596 6 P35232,P18085,P40616 3 +Skeletal muscle cell differentiation 0.5485539704737674 1.037741201371417 0.2993905576731142 1.0 0.7312992135149596 7 P50402,Q9BRT2 2 +Organelle disassembly 0.3367061936661071 1.0366666433876366 0.2998912427632374 1.0 0.7312992135149596 53 Q5THJ4,P21796,P27544,P04062,P30536,Q96HY6,Q13190,O43464,Q9BWH2,P53365,P12235,Q9Y3C8,Q86VR2,P52789,Q99623,Q9Y6I9,P05141 17 +Prenylation 0.7806191117092982 1.0357370664726298 0.3003248248170516 1.0 0.7312992135149596 2 P49354 1 +Negative regulation of glycoprotein metabolic process 0.7826655984485167 1.0346047960789015 0.3008535132668886 1.0 0.7312992135149596 3 Q9BXS4 1 +Reverse cholesterol transport 0.780282637954248 1.0343388294182403 0.3009777903541 1.0 0.7312992135149596 2 Q8WTV0 1 +Protein retention in golgi apparatus 0.7825647929989797 1.0342081830745424 0.3010388494274201 1.0 0.7312992135149596 3 Q5THJ4,Q9H4A6 2 +Neuron recognition 0.5949851226077627 1.0339125259824284 0.3011770586371065 1.0 0.7312992135149596 5 Q9NQC3 1 +Vitamin d metabolic process 0.7822282059912319 1.032884015058484 0.3016581802097109 1.0 0.7315269867523081 3 P04062,P38435 2 +Positive regulation of vasculature development 0.4001267274230437 1.0327535390255609 0.3017192514397462 1.0 0.7315269867523081 19 P09601,Q86UE4,P52789 3 +Positive regulation of cysteine type endopeptidase activity involved in apoptotic signaling pathway 0.7792732166891045 1.030145675810918 0.3029416264712874 1.0 0.7332926911661831 2 P49327 1 +Regulation of membrane invagination 0.7812184449680161 1.0289125664151098 0.3035207627205045 1.0 0.7332926911661831 3 Q06481,Q4KMQ2 2 +Regulation of anion transmembrane transport 0.5551575634784255 1.0283353014839176 0.3037921308643538 1.0 0.7332926911661831 6 P08183,Q15041,Q9HD26,O75915 4 +Regulation of inflammatory response 0.3617511057948468 1.0277233842599387 0.3040799647425127 1.0 0.7332926911661831 31 Q9H000,Q9BXW9,Q16539,Q99735,P04062,Q86UT6,O95219,Q8N2K0,P04083,P28070,P05067,Q08722,P33527 13 +Androgen metabolic process 0.6458781566645821 1.024645749217712 0.3055303696215774 1.0 0.7345483459403009 4 O95470 1 +Cell adhesion molecule production 0.6458096744069182 1.0243460163204117 0.3056718702950181 1.0 0.7346097489829058 4 Q9H4A6,O75955 2 +Immune effector process 0.3105769706545751 1.0231918158842723 0.3062171617183087 1.0 0.7349644531259865 68 Q9NQT5,Q9NUQ9,P01889,Q9NRA0,Q8N5M9,P35232,Q96FV9,P11279,Q06481,O15400,P14174,Q12846,Q99584,Q07021,P05067,P09601,O95219,P02786,P04083,P04439,Q99623,Q08722 22 +Phospholipid biosynthetic process 0.3238551923172637 1.021984271032271 0.3067883449339263 1.0 0.7349644531259865 58 O15269,Q9NUQ2,Q8NF37,O43292,Q9H490,Q92604,Q9NX62,Q9NTJ5,O14735,Q9NRA0,Q10713,O95674,Q9UBF8,Q9UG56,Q8WUK0,Q86YN1,Q96N66 17 +T cell apoptotic process 0.5368151560588192 1.0215276895722616 0.3070044972086589 1.0 0.7349644531259865 8 P24390 1 +Regulation of autophagy of mitochondrion in response to mitochondrial depolarization 0.5450890760162964 1.0199849423541727 0.3077356020982063 1.0 0.7352239826898783 7 O43464,Q16543,P52789,P04062 4 +Negative regulation of developmental growth 0.5145975616612335 1.0188848602161444 0.308257632077217 1.0 0.7355224479130583 9 Q13043,Q9NQC3 2 +Bone morphogenesis 0.5446324663476061 1.0176453305270785 0.3088465365889035 1.0 0.7363729052656016 7 O75844,Q9NX62 2 +Regulation of t cell mediated immunity 0.5444690337606064 1.0168079439535185 0.3092448023216012 1.0 0.7370450800253363 7 Q9NUQ9,P01889,P04439 3 +Establishment of protein localization to organelle 0.3914997424185125 1.0143369967370683 0.3104219761436362 1.0 0.7381843914676934 182 Q99595,Q53H12,Q5JRX3,Q96P70,O60830,Q9Y512,Q96RL7,O14925,P10909,P46379,Q53FT3,Q9Y371,P13473,Q10713,Q9Y5J9,P52292,O96008,Q8N4H5,Q9NS69,Q9Y5M8,O00505,O43615,Q9Y5L4,Q96DA6,Q16539,O43681,O95831,P30536,Q99442,Q8WWC4,Q8NFH5,Q15629,O14737,Q8N8Q8,O75381,P51572,Q15070,Q06481,P11279,P60059,Q9Y5J7,Q9P0J0,Q15005,P61026,Q3ZCQ8,Q9Y5Y5,P52789,Q9UHB9,Q15388,Q5THJ4,Q14108,Q92973,Q13043,Q99797,Q9Y5J6,Q9H1Z9,P40855,Q99623 58 +Response to testosterone 0.5352744334614334 1.0134275430734443 0.3108559889620923 1.0 0.7388007218818637 8 P49321,Q13126,P04062 3 +Cardiac conduction 0.4357274123008658 1.0130691264090064 0.3110271438168945 1.0 0.7388007218818637 15 P05023,O75844,Q6PI78 3 +Axon ensheathment in central nervous system 0.7765629394689086 1.0106233311262198 0.3121967447373914 1.0 0.7395849908289523 3 Q92542 1 +Regulation of leukocyte migration 0.379387632309836 1.0105135608018017 0.3122493057467808 1.0 0.7395849908289523 24 P14174,Q4KMQ2,P09601,P04083,Q8NHP6,Q07021,P05067,Q08722 8 +Peptidyl glutamic acid modification 0.6422465500546208 1.0087591909252658 0.3130901369000587 1.0 0.7403204241124447 4 Q8N0U8 1 +Phagosome maturation 0.6420875420875365 1.008064002455749 0.3134237375642583 1.0 0.7403204241124447 4 Q13636,P61106,P51149 3 +Regulation of tetrapyrrole metabolic process 0.7735531628533039 1.0064300568415356 0.314208741201057 1.0 0.741621600413076 2 O75027 1 +Regulation of adaptive immune response 0.3967488535948775 1.0058591803554455 0.3144833144376766 1.0 0.7416489960731237 19 Q96FV9,Q9NQT5,P01889,O15400,Q9NUQ9,P04083,P04439 7 +Dna templated transcription termination 0.5421029492788998 1.004686151986949 0.315047998342564 1.0 0.7416489960731237 7 O75844,Q16637 2 +Vascular process in circulatory system 0.3826422001889942 1.0044892284054088 0.3151428606245239 1.0 0.7416489960731237 22 P08183,P20020,P42892,P53985,Q16625,Q9HB40,P41440,P02786,P33527 9 +Regulation of systemic arterial blood pressure by hormone 0.7728802153432104 1.003645251354837 0.315549634905522 1.0 0.7422974144546907 2 P42892 1 +Quaternary ammonium group transport 0.7725437415881651 1.0022532770052373 0.3162212822704942 1.0 0.7436012706694806 2 Q9HC21 1 +Protein o linked glycosylation 0.4511318809805987 1.0017834331330724 0.3164482002680748 1.0 0.7436439704423305 13 Q6ZXV5,Q8N4A0,O43505 3 +Triglyceride metabolic process 0.4664533852331772 0.9992352568377244 0.3176807402892421 1.0 0.7444730951189374 11 Q92604,Q9UBV2,Q16822,Q8WTV0,Q96N66 5 +Peroxisome fission 0.639934530382076 0.9986543904566288 0.317962142222973 1.0 0.7444730951189374 4 O75192,P40855 2 +Mitotic nuclear membrane organization 0.5868751929281564 0.9957454957715424 0.3193738186561468 1.0 0.7458439421580229 5 Q9H6H4 1 +Negative regulation of protein secretion 0.465621572173332 0.9941107157565074 0.3201689689974307 1.0 0.7469389343064875 11 Q16836,P40939,Q8N5M9,Q16850 4 +Lactation 0.4880613410769694 0.9937573937748811 0.3203409933351429 1.0 0.7469389343064875 10 Q13505,P00403,P52789 3 +Vesicle cargo loading 0.441158484676826 0.9936575248886156 0.32038962814751 1.0 0.7469389343064875 14 Q15363,Q9NR31,Q96PC5,Q15436,P49755,Q15437 6 +Suckling behavior 0.7707224620871 0.9877310571044834 0.3232843800674492 1.0 0.7486474788933545 3 Q9GZP9 1 +Regulation of synaptic vesicle exocytosis 0.4640145332548581 0.9842107276749896 0.3250119122495956 1.0 0.7508936776444887 11 P16615,Q4J6C6 2 +Regulation of electron transfer activity 0.7684281386738456 0.9787551723789768 0.3277009639968311 1.0 0.7551784674135777 3 Q9NRA0,Q99623 2 +Negative regulation of blood pressure 0.6349574372117253 0.9769281972788508 0.3286047009964328 1.0 0.7561608357473308 4 Q9HB40,P42785 2 +Low density lipoprotein particle clearance 0.4850277014087036 0.9760854337670936 0.3290221290708155 1.0 0.7565717559577555 10 P09601,Q8WTV0 2 +Necrotic cell death 0.4024316082814301 0.9710468523759443 0.3315249479470381 1.0 0.758598684068309 18 Q13510,P49327,P00403,P12235 4 +Triglyceride biosynthetic process 0.5436603184931502 0.9709361561281716 0.3315800720102837 1.0 0.758598684068309 6 Q92604,Q8WTV0 2 +Regulation of steroid metabolic process 0.4293211111217796 0.9684613968397864 0.3328139893130366 1.0 0.7590952139838357 15 P05023,P16435,P30536,Q13510,O75477 5 +Isoleucine metabolic process 0.6328298685012117 0.9676526819333487 0.3332178572284321 1.0 0.759110848584118 4 A1L0T0 1 +Alpha ketoglutarate transport 0.7637954239569429 0.9661665615792102 0.3339608421474249 1.0 0.759110848584118 2 Q9BQT8 1 +Protein import into peroxisome membrane 0.7643890945809394 0.9629781636573768 0.3355584817127548 1.0 0.7608314179134988 3 Q9Y5Y5,P40855 2 +Protein import into peroxisome matrix 0.7643890945809383 0.9629781636573722 0.335558481712757 1.0 0.7608314179134988 3 Q9Y5Y5,O75381 2 +Keratan sulfate metabolic process 0.7633793335577111 0.959038986288308 0.3375391053615799 1.0 0.7633500348287127 3 O43505,P16278 2 +Neurofilament cytoskeleton organization 0.7611036339165529 0.9551055814042482 0.339524306718886 1.0 0.7649474990244497 2 Q16352 1 +Polyol metabolic process 0.3748906719210373 0.953892701201404 0.3401379584042792 1.0 0.7654614445794347 23 O15269,P04062,Q9NX62,Q9BW91,P35270,Q10713,Q13510 7 +Synaptic membrane adhesion 0.7604306864064692 0.9523436318493876 0.3409227366042544 1.0 0.7655337526770669 2 Q16539 1 +Negative regulation of receptor binding 0.7604306864064679 0.9523436318493832 0.3409227366042566 1.0 0.7655337526770669 2 P16615 1 +Response to sterol depletion 0.5395066361160437 0.9502282307802288 0.3419962969957653 1.0 0.7655337526770669 6 Q15363 1 +Cellular response to sterol depletion 0.5395066361160437 0.9502282307802288 0.3419962969957653 1.0 0.7655337526770669 6 Q15363 1 +Negative regulation of blood circulation 0.7610368165241463 0.949908685522688 0.3421586531693608 1.0 0.7655337526770669 3 P05023 1 +Cellular homeostasis 0.3598479115282527 0.9460072175730204 0.3441449049270064 1.0 0.7692865111900444 140 O75503,P09622,Q8N511,P35670,Q96A33,P13473,P50897,P05023,P51790,Q13586,P20020,Q8IYU8,Q7L0J3,Q9HD20,Q9HC07,Q8WWC4,Q8N5M9,Q8TAD4,P61421,P51572,Q92544,Q12846,Q9Y487,P16615,O76024,Q9NQC3,Q96AQ8,P10253,O43819,P05067,P52789,O75027,Q93050,Q8N183,Q9UM00,O95202,Q4KMQ2,Q9UJZ1,Q15043,P09601,Q15904,O75880,Q07820,P02786,Q9BWH2,P62942,Q16891 47 +Positive regulation of granulocyte chemotaxis 0.5756094211290382 0.9428578029267402 0.3457536410090567 1.0 0.7693815910676353 5 Q8NHP6 1 +Positive regulation of neutrophil migration 0.5756094211290382 0.9428578029267402 0.3457536410090567 1.0 0.7693815910676353 5 Q8NHP6 1 +Positive regulation of phagocytosis 0.5214489687912676 0.9407920949962794 0.3468114126831465 1.0 0.7708948418763977 8 Q06481,Q12907,Q4KMQ2,Q08722 4 +Bone remodeling 0.5295053695153684 0.9402119693977008 0.3471088433778371 1.0 0.771266769103499 7 O14773 1 +Telencephalon glial cell migration 0.5292434382244755 0.9388729551987584 0.3477959761719111 1.0 0.771266769103499 7 Q9NQC3 1 +Cerebral cortex radially oriented cell migration 0.5292434382244755 0.9388729551987584 0.3477959761719111 1.0 0.771266769103499 7 Q9NQC3 1 +Succinate metabolic process 0.6260511197531076 0.938151680683261 0.348166465917394 1.0 0.7717405743830269 4 P21912 1 +Cellular response to estradiol stimulus 0.757900971062708 0.9377045011099308 0.3483962900414736 1.0 0.7719798871677984 3 O95831 1 +Microglial cell activation 0.7578001477771552 0.9373124688716 0.3485978509565786 1.0 0.772093548827772 3 P05067 1 +Regulation of phospholipase a2 activity 0.6257616380381922 0.936893742881494 0.3488132181128782 1.0 0.772093548827772 4 P50897 1 +Hormone catabolic process 0.7574577656791671 0.9359813487313174 0.349282790789948 1.0 0.772586212979061 3 P42892 1 +Granulocyte migration 0.4160357706221645 0.9347447958740666 0.3499198352406076 1.0 0.772586212979061 16 Q8N5M9,Q8NHP6 2 +Zinc ion homeostasis 0.5736939729282488 0.9338844044621504 0.3503635243766796 1.0 0.772586212979061 5 Q8TAD4,Q15043 2 +Protein trimerization 0.6247996996267796 0.9327148229951916 0.3509672294556027 1.0 0.7730247053698811 4 P14174,Q99720 2 +Response to mitochondrial depolarisation 0.5195376236118117 0.9307614549508888 0.3519769723429538 1.0 0.7732485269918803 8 O43464,Q16543,P52789,P04062 4 +Response to corticosterone 0.7560941750719594 0.9306825456616042 0.3520178010681343 1.0 0.7732485269918803 3 P20020 1 +Negative regulation of immune response 0.3754858232251049 0.9301643344811028 0.3522860049918304 1.0 0.7732485269918803 21 Q96FV9,P01889,Q16539,Q86UT6,P09601,P04083,Q7Z739,P28070,P04439 9 +Appendage development 0.4549415528972831 0.9283421115463236 0.3532301363242023 1.0 0.7745631407455249 11 O75569,Q9NX62 2 +Posttranslational protein targeting to endoplasmic reticulum membrane 0.4764838018216757 0.926344517183018 0.354266967847916 1.0 0.775546126294268 10 O43681,P60059,Q9UGP8,P46379,Q99442 5 +Hepatocyte differentiation 0.7540376850605689 0.9261735296143764 0.3543558064811054 1.0 0.775546126294268 2 P04083 1 +Regulation of plasma lipoprotein particle levels 0.4304685354692381 0.9214380567231972 0.3568217673385425 1.0 0.7785373296120565 14 P09601,Q8WTV0 2 +Regulation of mitochondrial fusion 0.5705128883942663 0.9189957281015746 0.3580978066362972 1.0 0.7788402033575285 5 Q8N2A8 1 +Regulation of toll like receptor 3 signaling pathway 0.7529451363177293 0.918461814140239 0.3583771417185786 1.0 0.7788402033575285 3 P41440,O75955 2 +Regulation of heterotypic cell cell adhesion 0.7529451363177293 0.918461814140239 0.3583771417185786 1.0 0.7788402033575285 3 P41440,O75955 2 +Negative regulation of mrna processing 0.3953233134057268 0.9164360528617124 0.3594382330298238 1.0 0.7793208902241697 18 P61978,O75494,P38159,Q07021,O75150,P26368,P22626 7 +Adult behavior 0.3751877276674166 0.9160190996248364 0.3596568773354485 1.0 0.7793208902241697 20 O15118,Q92542,O75844,Q8N2K0,P50897,P05067,P51790 7 +Regulation of perk mediated unfolded protein response 0.7513458950201977 0.9151930549668778 0.3600902899677911 1.0 0.7793208902241697 2 P57088 1 +Positive regulation of receptor catabolic process 0.7513458950201927 0.9151930549668568 0.3600902899678022 1.0 0.7793208902241697 2 Q96J02 1 +Potassium ion import across plasma membrane 0.6206863829708008 0.9148664130875044 0.3602617642573404 1.0 0.7793208902241697 4 P05023 1 +Potassium ion homeostasis 0.6206863829708008 0.9148664130875044 0.3602617642573404 1.0 0.7793208902241697 4 P05023 1 +Carbohydrate transmembrane transport 0.4293732116221569 0.9140425082527514 0.3606945099297678 1.0 0.779847577541653 14 Q06481,O75298,P52789,Q16539 4 +Positive regulation of glycolytic process 0.7510094212651421 0.9138221608658664 0.3608102998854909 1.0 0.779847577541653 2 P05067 1 +Leukocyte mediated cytotoxicity 0.4375102136554373 0.9126901339400212 0.361405534291517 1.0 0.7806014523480259 13 P11279,P01889,O15400,Q9NUQ9,P04439 5 +Regulation of aerobic respiration 0.4521450771032521 0.911136003564143 0.3622237183587002 1.0 0.7818712382736899 11 P14406 1 +Autophagosome membrane docking 0.7503364737550553 0.9110814988962004 0.3622524338119144 1.0 0.7818712382736899 2 P16615 1 +Regulation of reactive oxygen species metabolic process 0.3558428024674673 0.9103872153087772 0.3626183376691623 1.0 0.7818854714344098 29 Q9BSK2,P42785,Q16539,P18085,P30536,P00374,P00403,O75027,P52789,P51790 10 +Learning 0.4209682284050486 0.9103196963353104 0.3626539341075241 1.0 0.7818854714344098 15 Q8NBU5,P18085,P50897,P05067,O00264 5 +Genitalia development 0.5681501291447888 0.9079490825115466 0.3639051238050497 1.0 0.7818854714344098 5 Q15392 1 +Adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 0.3581807683456647 0.906381116145782 0.3647341643985575 1.0 0.7818854714344098 28 Q96FV9,Q9NQT5,P01889,O15400,Q9NUQ9,P02786,P04083,P35232,Q07021,P04439 10 +Transcription dependent tethering of rna polymerase ii gene dna at nuclear periphery 0.567649225828048 0.9056085759364022 0.3651430679737482 1.0 0.7818854714344098 5 O75694,P78406,P57740 3 +Eosinophil mediated immunity 0.7489905787348639 0.9056047211446432 0.3651451090228343 1.0 0.7818854714344098 2 Q12846 1 +Eosinophil activation 0.7489905787348639 0.9056047211446432 0.3651451090228343 1.0 0.7818854714344098 2 Q12846 1 +Positive regulation of mast cell activation involved in immune response 0.7492426792325765 0.9041233175177484 0.3659300154408123 1.0 0.7821075060113177 3 Q9NRA0,O95219 2 +Positive regulation of mast cell activation 0.7492426792325765 0.9041233175177484 0.3659300154408123 1.0 0.7821075060113177 3 Q9NRA0,O95219 2 +Negative regulation of tumor necrosis factor superfamily cytokine production 0.747644683714676 0.900134084028288 0.3680488994346493 1.0 0.7834877941727226 2 P30536 1 +Vesicle tethering 0.5664722045802606 0.9001108133515261 0.3680612820375541 1.0 0.7834877941727226 5 O95772 1 +Chondrocyte differentiation 0.4431973590525884 0.899675282573462 0.368293080978878 1.0 0.7834877941727226 12 Q9NX62,Q15043,Q16539 3 +Cell migration involved in sprouting angiogenesis 0.5655313188815401 0.8957180302787892 0.370403378191539 1.0 0.7834877941727226 5 P09601 1 +Mitochondrial protein catabolic process 0.746298788694491 0.8946696831177882 0.3709636895846138 1.0 0.7834877941727226 2 Q9UG56 1 +Positive regulation of amyloid precursor protein biosynthetic process 0.7462188680851579 0.8924380392187776 0.3721581897693764 1.0 0.7834877941727226 3 P35610 1 +Mitochondrial ribosome assembly 0.6145659194180211 0.8883760426113768 0.3743385078694516 1.0 0.7834877941727226 4 Q567V2 1 +Biomineralization 0.4336895048162207 0.887728446946518 0.3746868401232386 1.0 0.7834877941727226 13 Q13586,Q6P4Q7,O75844,Q4KMQ2 4 +Vacuolar localization 0.4094367169949279 0.8873652307990915 0.3748822964682086 1.0 0.7834877941727226 16 Q86YV9,P09601,O95219,Q99584 4 +Lipid droplet formation 0.7443577452819734 0.8852574734270037 0.376017780734917 1.0 0.7834877941727226 3 Q14534 1 +Membrane raft organization 0.5107164819017183 0.8845226393276859 0.3764141468015967 1.0 0.7834877941727226 8 O75955,O15118,P50897 3 +Positive regulation of necrotic cell death 0.526090043041512 0.8834975775319115 0.3769674908074596 1.0 0.7834877941727226 6 P00403 1 +Cellular response to vascular endothelial growth factor stimulus 0.6132980609134835 0.8828993421752087 0.3772906590731328 1.0 0.7834877941727226 4 Q16539 1 +Response to bmp 0.4328843543548891 0.882470744510472 0.3775222936053066 1.0 0.7834877941727226 13 O00400 1 +Negative regulation of cytokine production involved in inflammatory response 0.7429340511440128 0.8810365987610556 0.3782980111878544 1.0 0.7834877941727226 2 Q06481 1 +Copi coated vesicle budding 0.5611861760136794 0.8754558823461974 0.3813259050383573 1.0 0.7834877941727226 5 Q15363,P49755 2 +Positive regulation of vacuole organization 0.524147764326281 0.873861810345465 0.3821935144284025 1.0 0.7834877941727226 6 Q9Y371 1 +Urogenital system development 0.3424284002010663 0.8735057166119732 0.3823874916968686 1.0 0.7834877941727226 39 O95470,Q9NZJ7,O75844,P07602,O76024 5 +Acute inflammatory response 0.5607043942624135 0.8732118227768643 0.3825476318635117 1.0 0.7834877941727226 5 Q9BQE5,P42785,Q4KMQ2 3 +Alpha linolenic acid metabolic process 0.7409152086137352 0.872876381427099 0.3827304611342979 1.0 0.7834877941727226 2 O95864 1 +Peptide transport 0.3453790823186255 0.8709416121784741 0.3837860344310921 1.0 0.7834877941727226 33 Q16836,Q8N183,Q12846,P00367,P53985,P22466,P62820,Q9BRT2,P40939,P04083,Q8N5M9,O95563,Q16822,Q03518,P33527 15 +Positive regulation of syncytium formation by plasma membrane fusion 0.5234477690229814 0.8703908723036027 0.3840868331679727 1.0 0.7834877941727226 6 Q14012,Q16539,O75955 3 +Regulation of syncytium formation by plasma membrane fusion 0.5234477690229814 0.8703908723036027 0.3840868331679727 1.0 0.7834877941727226 6 Q14012,Q16539,O75955 3 +Meiosis ii cell cycle process 0.7404914170313024 0.8703697214446052 0.3840983880523336 1.0 0.7834877941727226 3 O60566,Q96GX5 2 +Meiotic sister chromatid cohesion centromeric 0.7402422611036317 0.8701596554745838 0.3842131603284255 1.0 0.7834877941727226 2 O60566 1 +Negative regulation of inflammatory response 0.4384793600026019 0.8698089666891773 0.3844048104592101 1.0 0.7834877941727226 12 Q86UT6,Q16539,P04062 3 +Behavior 0.3010169040193792 0.8672273671441559 0.3858174441974793 1.0 0.7834877941727226 70 Q96RL7,Q99538,P54802,Q8N2K0,P50897,P51790,P04062,Q8NBU5,P18085,P30536,P17900,P53985,Q9GZP9,O75844,O76024,P10253,P05067,P22466,O75915,O15118,Q92542,O00264 22 +Adult locomotory behavior 0.4064452247634352 0.8659052523140381 0.3865421225626568 1.0 0.7834877941727226 16 O15118,O75844,Q8N2K0,P50897,P05067,P51790 6 +Glutamate receptor signaling pathway 0.7388710133277663 0.864142275613445 0.3875097377990379 1.0 0.7834877941727226 3 Q92542 1 +Regulation of glucose transmembrane transport 0.4298814001013027 0.8628704182085196 0.3882087167713162 1.0 0.7834877941727226 13 Q06481,O75298,P52789,Q16539 4 +Viral protein processing 0.521811198353631 0.8622797436475371 0.388533596798164 1.0 0.7834877941727226 6 P27824,Q10472 2 +Coenzyme a biosynthetic process 0.521790300107378 0.8621762037766362 0.3885905623580408 1.0 0.7834877941727226 6 Q8WVC6 1 +Regulation of golgi organization 0.5583157387233654 0.8620938441103808 0.388635878625696 1.0 0.7834877941727226 5 Q9P2W9 1 +Steroid catabolic process 0.6084589138624275 0.8620324995492795 0.3886696339683222 1.0 0.7834877941727226 4 Q8WTV0 1 +Negative regulation of gliogenesis 0.7382356728149226 0.8617025703471185 0.3888512108064761 1.0 0.7834877941727226 3 Q96G23 1 +Fatty acid beta oxidation using acyl coa oxidase 0.6082859228532573 0.8612876577552805 0.389079631621043 1.0 0.7834877941727226 4 O15254,Q15067 2 +Cerebellar purkinje cell layer morphogenesis 0.7380164597597445 0.8608610570344356 0.3893145721976563 1.0 0.7834877941727226 3 P04062 1 +Positive regulation of protein kinase b signaling 0.4209879457853547 0.8574773826254654 0.3911811092502835 1.0 0.7834877941727226 14 Q86UE4 1 +Regulation of phospholipid metabolic process 0.4644934092884525 0.8566762469141369 0.3916238341871279 1.0 0.7834877941727226 10 Q8NF37,Q9UJZ1,Q96DA6,Q8WTV0 4 +Cellular response to nutrient 0.556967339615371 0.8558237737386751 0.3920952631091641 1.0 0.7834877941727226 5 P09601 1 +T cell mediated immunity 0.4846866674371541 0.8538669856037826 0.3931786939550763 1.0 0.7834877941727226 9 Q9NUQ9,P01889,P04439 3 +Toll like receptor signaling pathway 0.4284777679142517 0.8537144066348914 0.3932632497542361 1.0 0.7834877941727226 13 P41440,P51812,Q9NQC3,O75955 4 +Positive regulation of ion transport 0.3410333512045408 0.8513057482391467 0.3945995326158575 1.0 0.7834877941727226 38 P08183,Q13586,P20020,Q15041,P14174,O75323,Q4KMQ2,Q96GC9,P30536,O95219,O00483,Q9NRA0,O76024,P22466 14 +Response to phorbol 13 acetate 12 myristate 0.7355316285329774 0.8511907167862693 0.3946634187576672 1.0 0.7834877941727226 2 Q9NRA0 1 +Phosphatidylglycerol biosynthetic process 0.734843484502953 0.8486960780003153 0.3960504291438522 1.0 0.7834877941727226 3 O95674 1 +Cytoplasm organization 0.734263772805497 0.8464766653710749 0.3972868859070471 1.0 0.7852768868084691 3 Q8N2A8 1 +Positive regulation of regulated secretory pathway 0.5108492082722055 0.8450856095177517 0.3980630423508113 1.0 0.7860946969512456 7 O95219,Q12846,Q9NRA0,P11279 4 +Homologous chromosome pairing at meiosis 0.5030788079795011 0.8445800465240992 0.3983453535590824 1.0 0.7860946969512456 8 P46379,Q9BXW9,Q92791,Q9BTX1 4 +Lens development in camera type eye 0.6043325742550516 0.8442878139600446 0.3985085940066928 1.0 0.7860946969512456 4 P08670,Q99797 2 +Negative regulation of steroid metabolic process 0.733423089868717 0.8432598983579066 0.399083105336389 1.0 0.7860946969512456 3 P05023,O75477 2 +Negative regulation of alcohol biosynthetic process 0.7331763122476528 0.8417387409104586 0.3999342080937433 1.0 0.7860946969512456 2 O75477 1 +Negative regulation of cholesterol metabolic process 0.7331763122476528 0.8417387409104586 0.3999342080937433 1.0 0.7860946969512456 2 O75477 1 +Humoral immune response mediated by circulating immunoglobulin 0.7324126176664831 0.8393962496185566 0.4012469877193862 1.0 0.787514338646191 3 Q07021 1 +Positive regulation of monooxygenase activity 0.5530386969166762 0.8375817432145323 0.4022656499064285 1.0 0.788231640011514 5 P00374,Q8WTV0 2 +Neuron death 0.3012639673689117 0.8360241317062526 0.4031413274143218 1.0 0.7887288659784654 73 Q01105,Q96A26,P04062,O95831,P09601,Q92542,Q15058,P49327,O76024,P50897,Q9NR28,Q4ZIN3,Q15392 13 +Regulation of oxidoreductase activity 0.4022392222461095 0.8357602607440044 0.4032897867324805 1.0 0.7887288659784654 16 P16435,P06280,Q9NRA0,Q8WTV0,P00374,Q99623,Q15070 7 +Regulation of natural killer cell mediated immunity 0.5526246405266587 0.8356614981598269 0.4033453610478417 1.0 0.7887288659784654 5 P11279,P04439 2 +Regulation of necrotic cell death 0.4256186433321322 0.8350764514712585 0.4036746644874598 1.0 0.789040110931212 13 Q13510,P00403,P12235 3 +Ensheathment of neurons 0.3551698457157863 0.8340813175052986 0.4042351621346849 1.0 0.7892979505369327 26 Q9NR77,O15121,Q92542,Q15058,O75746,Q16880 6 +Glycerolipid metabolic process 0.2951961359062455 0.8329805132576055 0.4048557195086157 1.0 0.7892979505369327 66 Q9NUQ2,Q53H12,O43292,Q92604,Q8NCC3,Q8N2K0,O14735,Q10713,Q8WUK0,Q96DA6,Q9H490,Q9NX62,Q9NTJ5,Q9UG56,P40939,Q9UBF8,Q8NF37,Q9UJZ1,Q9UBV2,O95674,Q8IY17,Q8WTV0,Q96N66 23 +Middle ear morphogenesis 0.6013947137256097 0.8316829956139508 0.4055879012503651 1.0 0.7892979505369327 4 P54802 1 +Ribonucleoside triphosphate biosynthetic process 0.3498412461311881 0.8286403123716014 0.4073079697462103 1.0 0.7906910867977448 28 P24539,Q9UJS0,P00846,Q9UJZ1,P56385,Q9NRA0,P00403,O75964 8 +Nadh oxidation 0.7298115746971723 0.828274921399621 0.4075148221617422 1.0 0.7906910867977448 2 Q16822 1 +Odontogenesis of dentin containing tooth 0.5073980521113013 0.8275580219009988 0.4079208498926889 1.0 0.7912365536038531 7 Q6P4Q7,P35613 2 +Anterior posterior axis specification 0.4798203099139911 0.8271344839506752 0.4081608407564878 1.0 0.7914597264133305 9 Q8N2A8,Q15363,Q5T9L3 3 +Cellular response to exogenous dsrna 0.5145517634493807 0.8263712215762233 0.4085935432215832 1.0 0.7918140398619548 6 O75955,Q9NUD5 2 +Response to dexamethasone 0.4994182233051124 0.8254748649069276 0.4091020469777464 1.0 0.7920725756736013 8 P16435,Q16822,P04062 3 +Cardiac ventricle development 0.4380585458704842 0.8246439421137134 0.4095737662331564 1.0 0.7925014688720361 11 O75844,Q6PI78 2 +Regulation of reactive oxygen species biosynthetic process 0.4990494117221406 0.823551537835716 0.4101944218678528 1.0 0.7932458888587635 8 Q9BSK2,O75027,P00403,P51790 4 +Cartilage development involved in endochondral bone morphogenesis 0.5994673255192855 0.8234273196265991 0.4102650325188803 1.0 0.7932458888587635 4 O75844 1 +Pigment metabolic process 0.3553192959310889 0.8166401899112823 0.4141340804689797 1.0 0.7974283889881417 25 P09601,P30519,P22830,O75027,O00264,P33527 6 +Cardiac muscle cell membrane repolarization 0.5123347417284765 0.8154299770864326 0.4148262310327451 1.0 0.797474242738182 6 O75844 1 +Membrane protein proteolysis 0.4365309322032547 0.8152886026909815 0.4149071311213652 1.0 0.797474242738182 11 Q9NZ08,Q16740 2 +Vascular transport 0.4573147829248634 0.8150880402618417 0.4150219169706961 1.0 0.797474242738182 10 P08183,P53985,P41440,P02786,P33527 5 +Centromere complex assembly 0.4971419851114442 0.8136092690470274 0.4158688261923937 1.0 0.797474242738182 8 Q92674,P50748,P49321 3 +Lens fiber cell development 0.7261103633916616 0.8135195047983484 0.4159202680358254 1.0 0.797474242738182 2 P08670 1 +Lens fiber cell differentiation 0.7261103633916616 0.8135195047983484 0.4159202680358254 1.0 0.797474242738182 2 P08670 1 +Protein peptidyl prolyl isomerization 0.3547035823008658 0.8111758364251958 0.417264699987689 1.0 0.7987060593248428 25 Q96AY3,Q9Y680,Q9NWM8,O95302 4 +Phospholipid metabolic process 0.3035217250703615 0.8104125847502266 0.417703087319681 1.0 0.7987168904829999 78 O15269,Q9NUQ2,O43292,Q92604,Q8NCC3,Q8N2K0,O14735,Q10713,Q8WUK0,Q96DA6,Q9H490,Q9NX62,Q9NTJ5,Q9NRA0,Q8NHP8,Q9UG56,P37268,P40939,Q9UBF8,Q86YN1,Q8NF37,Q9UJZ1,O95674,Q8IY17,Q8WTV0,Q96N66 26 +Glutamate biosynthetic process 0.7244777004048246 0.8091663701959686 0.4184194560387091 1.0 0.799272055528476 3 O75746 1 +Positive regulation of er associated ubiquitin dependent protein catabolic process 0.7239565671576198 0.807188078174978 0.4195581332352092 1.0 0.799272055528476 3 P51572 1 +Lipid modification 0.3194851599875955 0.8069681112495469 0.4196848555655106 1.0 0.799272055528476 52 Q16836,Q53H12,P35610,Q16539,P04062,P23786,Q9BWD1,P16435,O15254,Q15067,Q9NTJ5,P40939,Q9NRA0,O43808,Q10713,A1L0T0,Q96N66 17 +Glycosyl compound catabolic process 0.4758767969034079 0.8055096290871552 0.4205256520324898 1.0 0.799272055528476 9 P04062,P06280,Q9BTY2,Q13126,Q9NUJ1 5 +Intraciliary transport involved in cilium assembly 0.723755047106331 0.8041605679895976 0.4213042485784171 1.0 0.8000486854749017 2 A0AVF1 1 +Positive regulation of leukocyte migration 0.4128198726054451 0.802506875312037 0.4222598129448101 1.0 0.8006013461619099 14 Q4KMQ2,Q8NHP6,Q07021,P05067,Q08722 5 +Chromosome attachment to the nuclear envelope 0.7230820995962299 0.8014910991733909 0.4228473948868643 1.0 0.8006013461619099 2 O94901 1 +Bicarbonate transport 0.7227456258411838 0.8001571255879898 0.42361976697743 1.0 0.8008129440639146 2 Q9Y6M7 1 +Receptor clustering 0.4272225963151265 0.798725829908221 0.4244494059730734 1.0 0.8008129440639146 12 P49354,O15258,P57105 3 +Protein maturation by protein folding 0.5082381315966323 0.7952472359660165 0.4264696996169865 1.0 0.8029662591351373 6 O76024 1 +Positive regulation of b cell activation 0.4534889194861962 0.792973524271879 0.4277932482974096 1.0 0.8034598956312156 10 Q9NQT5,P14174,Q9NPF0 3 +Cellular response to molecule of bacterial origin 0.3561705926506797 0.7925424545298271 0.4280444474148259 1.0 0.80352497848097 23 P14174,Q16539,P30536,Q9NUQ9,Q86UE4,Q8WTV0 6 +Regulation of peptide transport 0.3560040548687608 0.7911098520814477 0.4288798905209823 1.0 0.8035547501424377 23 Q16836,Q8N183,Q12846,P00367,P53985,Q9BRT2,P40939,Q8N5M9,O95563,Q16822 10 +Negative regulation of oxidoreductase activity 0.7182075346599172 0.7854250278690463 0.4322044113909435 1.0 0.8052937110187147 3 Q15070 1 +Plasma membrane raft assembly 0.7181488493886033 0.7852034644735776 0.4323342845367131 1.0 0.8052937110187147 3 O75955 1 +Plasma membrane raft organization 0.7181488493886033 0.7852034644735776 0.4323342845367131 1.0 0.8052937110187147 3 O75955 1 +Negative regulation of anion transmembrane transport 0.718371467025575 0.7828624727113042 0.4337078767765345 1.0 0.8057300291435032 2 O75915 1 +Negative regulation of anion transport 0.718371467025575 0.7828624727113042 0.4337078767765345 1.0 0.8057300291435032 2 O75915 1 +Cytoplasmic pattern recognition receptor signaling pathway 0.4024123627880877 0.78152412385094 0.4344942939289125 1.0 0.8064491065004685 15 Q86UT6,O43657,Q9NUD5,P35232,Q07021,Q96J02 6 +Positive regulation of ire1 mediated unfolded protein response 0.7168702042386356 0.780379040666906 0.4351678010050341 1.0 0.8065500349230226 3 P57088 1 +Positive regulation of endoplasmic reticulum unfolded protein response 0.7168702042386356 0.780379040666906 0.4351678010050341 1.0 0.8065500349230226 3 P57088 1 +Cognition 0.3418363011505039 0.7776327148838634 0.4367855689451383 1.0 0.8085389905019141 29 Q99538,Q8NBU5,P18085,Q92542,Q9H0U3,P17900,P50897,P05067,O00264,O75915 10 +Regulation of nitric oxide synthase activity 0.5044291373979708 0.7765247942528377 0.437439186997977 1.0 0.8089924141473795 6 P06280,Q8WTV0 2 +Export from cell 0.3463141115974554 0.7727901217309151 0.4396466004863797 1.0 0.8090333089632752 139 Q7Z6M1,P51151,Q13636,Q9H4A6,Q9BRT2,P35670,P50897,P05023,O00560,Q86YV9,Q9P253,Q16836,P20020,Q96KC8,Q5T9L3,Q7L0J3,P27824,Q9BRK5,Q9NRA0,Q8N5M9,Q16850,P49755,Q96PC5,Q32P28,P33527,P08183,P11279,P53985,Q12846,P14174,Q99584,Q8TBQ9,P16615,P40939,P61026,O15498,P22466,Q8N183,Q9HCU5,Q4KMQ2,P62820,P09601,O95219,P04083,Q15758,Q9UBV2,O43760,Q4J6C6 48 +Positive regulation of g protein coupled receptor signaling pathway 0.7142933773106297 0.7706743829275636 0.4408999596838343 1.0 0.8090333089632752 3 Q15043 1 +Regulation of atp metabolic process 0.3479425369046128 0.7689464049594441 0.4419251276778162 1.0 0.8090333089632752 26 P34897,Q9BSK2,P14406,P30536,Q9BRT2,Q9NRA0,P00403,P05067,O75746 9 +Bone growth 0.7135944153302478 0.7680461959525537 0.4424597402486341 1.0 0.8090333089632752 3 O75844 1 +Growth plate cartilage development 0.7135944153302478 0.7680461959525537 0.4424597402486341 1.0 0.8090333089632752 3 O75844 1 +Regulation of receptor internalization 0.4283798358263828 0.7654797556439537 0.443985916841044 1.0 0.8090333089632752 11 Q8NBU5,Q9UHD9,P41440,O75955 4 +Gland development 0.2990347446338577 0.7644665966349335 0.4445892352567084 1.0 0.8093197395099152 60 Q13505,P35610,Q5T9L3,Q9NZJ7,P09601,O75844,P07602,P35670,P49327,P00403,Q9NQC3,P52789 12 +Plasma membrane to endosome transport 0.7124783988694747 0.7638535968590027 0.4449544928663651 1.0 0.8093197395099152 3 Q8N668 1 +Chemical homeostasis 0.3680586557822691 0.7638179110080138 0.4449757616490755 1.0 0.8093197395099152 174 O75503,P35610,P42785,Q9Y5X3,Q8N668,Q16891,Q8N511,P35670,P30519,Q96A33,P50897,Q96CP7,P05023,Q86YV9,P51790,Q13586,P20020,O15260,P04062,Q8IYU8,Q7L0J3,Q9HD20,Q9HC07,P30536,Q8WWC4,Q8N5M9,Q8TAD4,P61421,P51572,Q6P4Q7,Q9Y6C9,Q92544,Q06481,Q12846,P53985,Q9Y487,P16615,O15254,O76024,Q9NQC3,Q96AQ8,O43819,P05067,P52789,Q16739,O75027,Q5BJF2,Q93050,Q8N183,Q9UM00,Q8NE01,O15118,Q8NF37,O95202,Q9UJZ1,Q15043,P09601,Q15904,Q15067,O75880,P02786,Q9BWH2,P62942,P17480,Q9P035,Q8WTV0 66 +Response to hyperoxia 0.5369053085092513 0.7631395731568974 0.4453801615385591 1.0 0.8093197395099152 5 P00846 1 +Vesicle targeting rough er to cis golgi 0.4482377200840953 0.7626878271277416 0.4456495919454084 1.0 0.8093197395099152 10 Q9NR31,P49755,Q15363 3 +Positive regulation of adaptive immune response 0.4068651345790192 0.762548535761832 0.445732686842951 1.0 0.8093197395099152 14 Q9NQT5,P01889,O15400,Q9NUQ9,P04439 5 +Regulation of protein tyrosine kinase activity 0.4213830736003563 0.7619845167766615 0.4460692451556338 1.0 0.8094668198398568 12 Q13432,P05067,O95684 3 +Positive regulation of pattern recognition receptor signaling pathway 0.4678000093320418 0.7613461917976772 0.4464503174512404 1.0 0.8095897557982195 9 O75955,Q9NQC3,Q9NUD5 3 +Regulation of monocyte chemotaxis 0.5364240392751615 0.7609320764597315 0.4466976383757255 1.0 0.8095897557982195 5 Q8NHP6,Q4KMQ2 2 +Vitamin metabolic process 0.3448821465063411 0.7608009405097991 0.446775972576255 1.0 0.8095897557982195 27 Q9HC21,P04062,Q8N0U8,Q9H2D1,P41440,P38435,P00374,P33527 8 +Positive regulation of anion transmembrane transport 0.5845950342125837 0.7601289325658838 0.4471775198789283 1.0 0.8098540847435708 4 Q15041 1 +Retinal metabolic process 0.7112083473577746 0.7590880216348911 0.4477999040951277 1.0 0.8100388917372106 3 Q9BTZ2,Q8NBN7 2 +Protein localization to cilium 0.4270840279028576 0.757580773638157 0.4487019936736165 1.0 0.8102984976973662 11 P18085,Q10713 2 +Inositol phosphate metabolic process 0.4932309155016793 0.7559240733051961 0.4496947196147929 1.0 0.8115807628167928 7 Q9BW91,Q10713 2 +Regulation of transmembrane transport 0.2937526230704188 0.7547596820454271 0.4503931892125055 1.0 0.8115807628167928 71 Q9BVC6,Q8N668,P0CG08,Q13586,P21796,Q16539,O00483,Q9NRA0,Q8TAD4,P08183,Q06481,P27105,O75844,O75298,P05067,P52789,P22466,O75915,Q15041,O75323,Q4KMQ2,Q96GC9,Q16625,P62942,Q99623 25 +Retrograde transport endosome to golgi 0.3333499821772629 0.7534292645905913 0.451192002651982 1.0 0.8115807628167928 34 O15260,Q8NBN3,O75503,P51151,Q9Y5X3,Q13190,Q8N1B4,P40616,O60499,O15498,O95249,Q4J6C6 12 +Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress 0.3980853814142848 0.7516239903881926 0.4522772120032474 1.0 0.8115807628167928 15 O60313,O95831,P46379,O76024 4 +Leukocyte migration 0.3282975772876323 0.7511559495003529 0.4525588072822379 1.0 0.8115807628167928 42 P14174,Q4KMQ2,P04062,P35613,P09601,Q9H4A6,P04083,Q8N5M9,Q8NHP6,Q07021,P05067,Q08722 12 +Nucleobase containing compound transport 0.3180953712843419 0.7510335686903901 0.4526324536301753 1.0 0.8115807628167928 102 Q9HC21,O00400,P51991,P41440,P22626,P05141,O75955,Q9BTX1,P41208,Q9H2D1,L0R6Q1,Q8NFH5,Q96FV9,P78406,Q92945,P12236,Q9BSK2,Q15388,Q86VD7,Q8TB61,Q6NUK1,O43808,P12235,Q08722 24 +Positive regulation of endocytosis 0.3550947362792463 0.750222899721801 0.453120469075869 1.0 0.8115807628167928 20 Q06481,Q4KMQ2,Q8NBU5,Q13636,P41440,P50897,O75955 7 +L methionine salvage from methylthioadenosine 0.70851565129584 0.7490047108640964 0.4538543660698284 1.0 0.8115807628167928 3 Q13126,Q9UHY7 2 +Amino acid salvage 0.70851565129584 0.7490047108640964 0.4538543660698284 1.0 0.8115807628167928 3 Q13126,Q9UHY7 2 +Maintenance of location in cell 0.329556350103704 0.7464659362841363 0.4553860013690958 1.0 0.8115807628167928 40 P24390,O95202,O43292,Q9H4A6,P35670,O15258,P10253,P62942,P52789 9 +Lymphocyte mediated immunity 0.3358102306047157 0.7455945362473284 0.4559123844469375 1.0 0.8115807628167928 30 Q96FV9,Q9NQT5,P01889,P11279,O15400,Q9NUQ9,P02786,Q07021,P04439 9 +Negative regulation of mrna metabolic process 0.3273541420151778 0.7410294512420099 0.4586755833563782 1.0 0.8130133801238546 42 Q14103,Q16539,P61978,Q13151,P35637,O75494,P38159,Q99729,Q14011,Q92804,O60506,Q07021,O75150,P26368,P22626 15 +Epigenetic maintenance of chromatin in transcription competent conformation 0.532011541175818 0.7407327415487225 0.458855503020944 1.0 0.8131047864720784 5 Q969T9 1 +Body fluid secretion 0.4238946888478235 0.7381649717738955 0.460414205837182 1.0 0.8135070357126736 11 Q13505,P00403,P52789 3 +Leukotriene metabolic process 0.5313572971234648 0.7377441044773905 0.4606699653928925 1.0 0.8135070357126736 5 Q99735,P33527 2 +Neurotransmitter metabolic process 0.705433405287513 0.7374975334805696 0.4608198426062819 1.0 0.8135070357126736 3 P21964 1 +Golgi to plasma membrane protein transport 0.3959951889812724 0.7372059050710031 0.4609971429742834 1.0 0.8135070357126736 15 Q9HD26,Q13636,Q9H4A6,Q8N2H4,P61026,Q4J6C6 6 +Histone h3 k9 acetylation 0.5784904032124196 0.7343785909804263 0.4627180311776866 1.0 0.8139456554789597 4 Q03164,Q14012 2 +Endocrine process 0.5304111178932833 0.7334248727112199 0.4632993335561941 1.0 0.8143732736066841 5 P42892,P22466 2 +Regulation of defense response to virus 0.3952753932461249 0.7322449676392682 0.4640190622861824 1.0 0.8149898083037964 15 O43657,O75844 2 +Glycerophospholipid metabolic process 0.2989031264671387 0.7315391178541824 0.4644499200849683 1.0 0.8150388486809624 59 Q9NUQ2,O43292,Q92604,Q8NCC3,Q8N2K0,O14735,Q10713,Q8WUK0,Q96DA6,Q9H490,Q9NX62,Q9NTJ5,Q9UG56,P40939,Q9UBF8,Q8NF37,Q9UJZ1,O95674,Q8IY17,Q8WTV0,Q96N66 21 +Folic acid containing compound metabolic process 0.4017312796872068 0.7282005359785116 0.4664908378202215 1.0 0.8151307267853577 14 P34897,P31939,Q9H2D1,P41440,P00374 5 +Synaptonemal complex organization 0.494303260348341 0.726983487837015 0.4672360710281227 1.0 0.8151307267853577 6 Q92791 1 +Sterol homeostasis 0.4157420110106506 0.7266052568314754 0.4674678070180984 1.0 0.8151307267853577 12 P35610,O15118,Q8WTV0 3 +Negative regulation of defense response 0.336314545729392 0.7253984411324341 0.468207629148003 1.0 0.8151307267853577 29 P01889,Q16539,P04062,Q86UT6,O43657,P04439,Q7Z739,P28070,Q96J02 9 +Negative regulation of cell growth 0.3450015996612479 0.7252206257663283 0.4683166912463883 1.0 0.8151307267853577 25 Q9NQC3,P50897 2 +Plasma membrane organization 0.3308513977665746 0.7245529324847869 0.4687263428806487 1.0 0.8151307267853577 31 Q12846,Q4KMQ2,O15121,P16615,Q9Y371,Q96CP7,Q16739,O75955 8 +Intracellular mrna localization 0.7028936742934103 0.7224156602762413 0.4700389615683804 1.0 0.8151373724433864 2 Q99729 1 +Cellular lipid metabolic process 0.3844585964883831 0.7191163760941476 0.4720692180554151 1.0 0.8171943432873787 209 Q8NBX0,Q53H12,Q92604,Q8NCC3,Q15800,Q9H7Z7,Q8N2K0,O14735,P50897,Q16836,Q96DA6,P04062,P07602,Q9HB40,Q9NTJ5,Q9NRA0,Q92643,Q16880,O75844,Q8N4Q0,Q13510,P51648,Q16739,Q86YN1,Q8NF37,A1L0T0,Q9P035,Q9NUQ2,Q96G23,O95470,Q9H3H5,Q9NZ01,Q9H490,Q9NZJ7,P17900,Q8NHP8,Q9BT22,P37268,P23786,Q9BV10,Q8NBN7,P27544,Q9BWD1,O15121,Q15067,O95674,Q8WTV0,Q96N66,O15269,P35610,Q53GQ0,Q96AA3,Q10713,P16278,Q16539,Q99735,Q9NX62,Q9UG56,Q99805,O00767,P07099,P06280,P49327,Q6Y1H2,Q06136,Q9UBV2,Q8IY17,O75477,P17050,O43292,O95864,Q8WUK0,P16435,O00116,Q2TAA5,P14174,Q6NUM9,O15254,P06865,P40939,Q9BY49,Q9UBF8,Q9UJZ1,O43808,P04083,Q9Y394 86 +Negative regulation of neuron death 0.3253028334097911 0.7190208620211885 0.4721280657350917 1.0 0.8171943432873787 42 Q01105,P04062,P09601,P50897,Q4ZIN3 5 +Negative regulation of natural killer cell mediated immunity 0.7000387078121648 0.7174501562969534 0.4730963810545794 1.0 0.817976412112653 3 P04439 1 +Cellular modified amino acid catabolic process 0.485241626190294 0.7158030075692715 0.4741129950701952 1.0 0.8189638461307974 7 Q9UHG3 1 +Mononuclear cell migration 0.349699781002698 0.7145586694986311 0.4748817911797871 1.0 0.8189638461307974 21 Q4KMQ2,P04062,P04083,Q8NHP6,Q07021,P05067,Q08722 7 +Cellular response to virus 0.3484389627824086 0.7142226325618559 0.4750895239985289 1.0 0.8189638461307974 22 Q16539,Q86UT6,O43657,Q9NUD5,P35232,Q07021 6 +Membrane biogenesis 0.3416503687300831 0.7123737187856739 0.4762333854220348 1.0 0.8203857298853472 26 Q9H6H4,Q12846,Q86XL3,Q9Y5Y5,Q96CP7,Q16739,O75955 7 +Fucose metabolic process 0.6985717241790099 0.7120198268933905 0.4764524985145326 1.0 0.8203857298853472 3 Q9BTY2 1 +Cerebellar cortex morphogenesis 0.4912248989422416 0.7119968454657496 0.4764667294351823 1.0 0.8203857298853472 6 P04062 1 +Lipid phosphorylation 0.6982245886620673 0.7107361920720677 0.4772477276660196 1.0 0.8203857298853472 3 Q53H12 1 +Cytokine production involved in inflammatory response 0.4908342519318555 0.7100977260072168 0.4776435363752005 1.0 0.8203857298853472 6 Q06481,Q16539,Q8IV08 3 +Acetyl coa biosynthetic process from pyruvate 0.490827356879946 0.7100642114845311 0.4776643182252944 1.0 0.8203857298853472 6 P09622,P11177,O95563 3 +Negative regulation of cytokine production 0.3432750197261192 0.7099625164199924 0.4777273808282629 1.0 0.8203857298853472 25 Q06481,P20020,P04062,Q86UT6,P30536,P09601,P04083,Q96J02 8 +Negative regulation of organic acid transport 0.6977448670481249 0.7089631418564689 0.4783473498554003 1.0 0.821005272645343 3 Q9Y3D6,O75915 2 +Long chain fatty acid transport 0.4127614037805855 0.7079639889835438 0.4789676206249393 1.0 0.8214938892636822 12 P50416,P14174,O43772,P23786,O95573,P04083,P28288 7 +Detection of stimulus 0.3915957928189704 0.7069208221608794 0.4796156834431548 1.0 0.8215251021456198 15 Q13586,P30536,Q13432,P04439,Q8WTV0 5 +Regulation of histamine secretion by mast cell 0.6970716930326375 0.7064767835019138 0.479891685597881 1.0 0.8215251021456198 3 P51809,O95219 2 +Bone mineralization 0.4756834395563684 0.7024518534440398 0.4823974174618453 1.0 0.8225406646043794 8 O75844,Q4KMQ2 2 +Ketone biosynthetic process 0.4892156211150998 0.7022354818371641 0.4825323213606607 1.0 0.8225406646043794 6 O75208,Q14849 2 +Positive regulation of fatty acid oxidation 0.6975100942126519 0.701687702696226 0.4828739436742968 1.0 0.8225406646043794 2 P50416 1 +Positive regulation of lipid catabolic process 0.6975100942126519 0.701687702696226 0.4828739436742968 1.0 0.8225406646043794 2 P50416 1 +Positive regulation of fatty acid beta oxidation 0.6975100942126519 0.701687702696226 0.4828739436742968 1.0 0.8225406646043794 2 P50416 1 +Negative regulation of fatty acid transport 0.6975100942126508 0.7016877026962214 0.4828739436742997 1.0 0.8225406646043794 2 Q9Y3D6 1 +Negative regulation of anoikis 0.6950521709861945 0.6990296831361695 0.48453348070649 1.0 0.8225406646043794 3 Q07820,Q9Y3E5 2 +Regulation of neurotransmitter uptake 0.6950521709861862 0.6990296831361404 0.4845334807065082 1.0 0.8225406646043794 3 P41440,O75955 2 +L glutamate import across plasma membrane 0.695052170986181 0.6990296831361212 0.4845334807065202 1.0 0.8225406646043794 3 Q15041,O75915 2 +Regulation of amino acid transmembrane transport 0.695052170986181 0.6990296831361212 0.4845334807065202 1.0 0.8225406646043794 3 Q15041,O75915 2 +Regulation of l glutamate import across plasma membrane 0.695052170986181 0.6990296831361212 0.4845334807065202 1.0 0.8225406646043794 3 Q15041,O75915 2 +Eye morphogenesis 0.4370095730538063 0.6982513986084786 0.4850199878115246 1.0 0.8225406646043794 10 Q8NBN7 1 +Regulation of defense response 0.2954068829814722 0.6982294260982701 0.4850337267076958 1.0 0.8225406646043794 78 O43657,Q8N2K0,Q8IZ81,Q9H000,P01889,Q16539,Q99735,P04062,Q16543,P33527,Q06481,P11279,Q9BXW9,Q86UT6,O75844,P12956,Q7Z739,P28070,Q07021,P05067,Q9BUI4,Q96J02,Q9NZ08,P18031,O95219,P04083,Q9NUD5,P04439,Q08722 29 +Mitochondrial genome maintenance 0.4556821959021447 0.6954854893102427 0.4867511017741703 1.0 0.8225406646043794 9 Q9BSK2,P12235 2 +Positive regulation of i kappab kinase nf kappab signaling 0.3275229440198642 0.6950561533704561 0.487020111510853 1.0 0.8225406646043794 34 Q8IUH4,Q5T9L3,O43657,P09601,Q8TB61,Q86UE4,P62942 7 +Sensory perception of mechanical stimulus 0.38979208675805 0.694530867273166 0.4873493501029244 1.0 0.8225406646043794 15 Q9Y5J7,Q9Y6M9,Q14108,O76024,Q9Y5J9 5 +Positive regulation of protein localization to cell surface 0.5688450500344037 0.694008700092122 0.4876767528914258 1.0 0.8225406646043794 4 Q12846 1 +Membrane raft assembly 0.5213814493729421 0.69239320523987 0.4886904317325604 1.0 0.8225406646043794 5 P41440,O75955 2 +Cellular defense response 0.6948183041722862 0.691385514804225 0.4893233045464384 1.0 0.8225406646043794 2 Q08380 1 +Spontaneous synaptic transmission 0.6948183041722789 0.6913855148041982 0.4893233045464553 1.0 0.8225406646043794 2 P05067 1 +Regulation of spontaneous synaptic transmission 0.6948183041722789 0.6913855148041982 0.4893233045464553 1.0 0.8225406646043794 2 P05067 1 +Lymphocyte apoptotic process 0.4033843776598083 0.6909774615567386 0.4895797049741954 1.0 0.822560212343243 13 P49327,P24390 2 +Neutrophil chemotaxis 0.4160345617513967 0.6904913949018922 0.4898852195172005 1.0 0.8227526154934957 11 Q8NHP6 1 +Negative regulation of rna splicing 0.4029765140840969 0.6883528422475833 0.4912306128203914 1.0 0.8238791454822166 13 P61978,O75494,P38159,Q07021,P26368,P22626 6 +Endoplasmic reticulum to cytosol transport 0.4024797953455695 0.6851575778586008 0.4932444901801505 1.0 0.8238791454822166 13 P51572,Q9UBV2,Q9GZP9,Q9BUN8 4 +Cytoplasmic pattern recognition receptor signaling pathway in response to virus 0.4018454155731388 0.6810786248726676 0.4958217414759951 1.0 0.8246138216542555 13 Q86UT6,O43657,Q9NUD5,P35232,Q07021 5 +Copii coated vesicle budding 0.3456461218072824 0.6808920413268615 0.4959398043413912 1.0 0.8246138216542555 21 Q15363,Q9NR31,Q9HCU5,Q15436,P49755,Q15437 6 +Negative regulation of leukocyte migration 0.5183532023523546 0.678714049465888 0.4973190624309729 1.0 0.8258233972477623 5 P09601 1 +Protein localization to lysosome 0.3941887807553301 0.6779497264979572 0.497803569485582 1.0 0.8260624483365516 14 Q9NQC3 1 +Regulation of biomineralization 0.4837435657915461 0.6757392562177773 0.4992062072672607 1.0 0.8261850606181291 6 O75844,Q4KMQ2 2 +Negative regulation of response to external stimulus 0.3217783846983785 0.6724093955234506 0.5013231030590353 1.0 0.8261850606181291 41 P01889,P14174,Q16539,Q96G23,P04062,Q86UT6,O43657,P04439,Q7Z739,P28070,Q96J02,P80303 12 +Synaptic vesicle membrane organization 0.5165837729492936 0.6707414909149285 0.5023852262434163 1.0 0.8267378936854327 5 O43760 1 +Clathrin dependent endocytosis 0.3790614360828758 0.6706596174722934 0.5024373939524729 1.0 0.8267378936854327 16 Q13432 1 +Regulation of ossification 0.4688181849116631 0.667230382246158 0.5046249871444517 1.0 0.8291496174256034 8 O75844,Q16539,Q4KMQ2 3 +Membrane repolarization 0.4754825644367833 0.6671311164609256 0.5046883859184099 1.0 0.8291496174256034 7 O75844 1 +Sodium ion export across plasma membrane 0.6855726584278687 0.664323031587414 0.5064835831732615 1.0 0.8303761644416696 3 P05023 1 +Cellular potassium ion homeostasis 0.6855726584278687 0.664323031587414 0.5064835831732615 1.0 0.8303761644416696 3 P05023 1 +Cellular sodium ion homeostasis 0.6855726584278687 0.664323031587414 0.5064835831732615 1.0 0.8303761644416696 3 P05023 1 +Fatty acid transport 0.3702501174431325 0.6626564034945005 0.5075506373642109 1.0 0.8305737582369317 17 P50416,P14174,P31751,O43772,P23786,O95573,O43808,P04083,Q9Y3D6,P28288 10 +Anatomical structure maturation 0.3292230251868075 0.658502972816178 0.5102149874089807 1.0 0.833688920617976 29 O75503,O75787,Q12768,P04062,Q9NZJ7,P09622,Q8N2A8,Q15058,Q9Y2W6,P05067,P22466 11 +Interleukin 6 production 0.3844647430787252 0.6580386046543477 0.5105133251239189 1.0 0.833708914790195 15 P01889,P04062,Q86UT6,Q9NRA0,Q08722 5 +Cytokine production involved in immune response 0.4038314658997344 0.6523706798875268 0.5141620741279518 1.0 0.8340211027557396 12 P09601,P14174,P04439 3 +Lipid droplet organization 0.4658172424385154 0.6518987541898835 0.514466488655605 1.0 0.8340211027557396 8 Q14534 1 +Embryonic axis specification 0.4724004919133033 0.6518475527757843 0.5144995216368478 1.0 0.8340211027557396 7 Q8N2A8,Q15363 2 +Embryonic pattern specification 0.4724004919133033 0.6518475527757843 0.5144995216368478 1.0 0.8340211027557396 7 Q8N2A8,Q15363 2 +Regulation of programmed necrotic cell death 0.4651127494953854 0.6483056211142719 0.5167872991007503 1.0 0.836085714773972 8 Q13510 1 +Neuromuscular process controlling balance 0.4281457516554838 0.6477679537453901 0.5171350452985184 1.0 0.836085714773972 10 P17900,P05067,O14773,P10253 4 +Regulation of tube size 0.477883159558948 0.6475166159891524 0.5172976441377353 1.0 0.836085714773972 6 Q9HB40,P42892 2 +Regulation of phosphatidylcholine metabolic process 0.557386061754021 0.6466129611149359 0.5178824674191083 1.0 0.8363979570444077 4 Q8NF37 1 +Negative regulation of mrna catabolic process 0.3356954733069844 0.6431767012387841 0.5201094494576726 1.0 0.8379688103546173 25 Q16539,Q14103,P35637,Q99729,Q14011,Q92804,O60506 7 +Positive regulation of immunoglobulin production 0.4080150027783711 0.6421587183725677 0.5207701337441017 1.0 0.8385107414620824 11 P02786,Q12846,Q9NQT5,P35232 4 +Heart process 0.3336344266153523 0.6405898170452455 0.5217892172443637 1.0 0.8391001141480674 26 P05023,O75844,P16615,Q6PI78 4 +Chaperone mediated autophagy 0.4696306604803998 0.6381518447720972 0.523374840623966 1.0 0.8402837345109578 7 P10619,P13473 2 +Animal organ morphogenesis 0.2925912817643475 0.6371123609005094 0.524051657581194 1.0 0.8402837345109578 80 Q15363,Q8NBN7,Q16539,P04062,O95470,P16435,P35613,O75844,P54802,Q9NX62,Q9NQC3,P10253,P53701,P62942,Q8TAA9,O75569 16 +Regulation of lipid metabolic process 0.3014487746242337 0.6335459506680438 0.5263771837346178 1.0 0.8424960735115725 54 Q96G23,Q92604,P05023,Q96DA6,Q9NZJ7,P16435,P30536,P07602,Q9NRA0,Q9UBM7,Q06481,O75844,Q9H6K4,Q13510,P22466,Q8NF37,Q9UJZ1,P04083,Q8WTV0,O75477,Q96N66 21 +Multi multicellular organism process 0.3338978307556129 0.6273928383550703 0.5304017610443106 1.0 0.8459454069022425 25 Q15363,Q9UIQ6,Q9BQE5,P35613,P41440,Q9NRA0,P07858,Q7Z739 8 +Fat cell differentiation 0.3389682030210253 0.6256657537771956 0.5315342002147305 1.0 0.8473249014495012 21 Q13043,Q9NZ08,Q16539,Q8N4Q0 4 +3 utr mediated mrna destabilization 0.4728601596362505 0.6234656971588778 0.5329785372934801 1.0 0.8483464908930142 6 Q92945,Q9HCE1 2 +Vesicle targeting 0.3372700677473548 0.6203576716380061 0.5350223335176962 1.0 0.8490454214088694 22 Q15363,Q9NR31,Q14849,O95772,O15498,P49755 6 +Aggrephagy 0.6749663526244971 0.6167893962417058 0.5373736470177031 1.0 0.8510655134642873 2 Q5T8D3 1 +Regulation of epidermal growth factor activated receptor activity 0.6721642544597675 0.6159912133259396 0.5379003189924392 1.0 0.8510776907812335 3 P05067,Q9UNH7 2 +Regulation of b cell proliferation 0.5036793695449034 0.6130905440735993 0.5398164722610721 1.0 0.8521815080807412 5 P02786,P14174,Q9NPF0 3 +Glycine biosynthetic process 0.6698543002434645 0.607761626592399 0.5433455833410683 1.0 0.8539057976843631 3 P00374 1 +Regulation of cell activation 0.2870170327930801 0.6063319727073175 0.5442943314548947 1.0 0.8545268781151849 60 Q9NQT5,Q9NUQ9,Q9NPF0,Q15418,Q9NRA0,Q96FV9,P11279,Q9BXW9,P14174,Q12846,O96005,P12956,Q96J02,P22466,Q14254,P09601,O95219,P02786,P04083,Q9BWH2,P04439,Q08722 22 +Retinol metabolic process 0.463032702535065 0.6056894788312073 0.5447209718199639 1.0 0.8546343237604334 7 Q9BTZ2,Q8NBN7,Q9Y394,Q6NUM9 4 +Negative regulation of epidermal growth factor activated receptor activity 0.6719380888290729 0.6056405091766336 0.5447534963448508 1.0 0.8546343237604334 2 Q9UNH7 1 +Response to ischemia 0.4626719519473541 0.6039215073585937 0.5458958289528888 1.0 0.8554489205622365 7 P52789 1 +Ventricular cardiac muscle tissue development 0.5010907351861146 0.6016387132541307 0.547414653566971 1.0 0.8554489205622365 5 O75844 1 +Hormone transport 0.3179505662518048 0.601479893835729 0.5475203995331488 1.0 0.8554489205622365 35 Q16836,Q8N183,Q12846,P00367,P53985,P62820,P51809,O95219,Q9BRT2,P40939,P04083,Q8N5M9,O95563,Q16822,P22466 15 +Regulation of phagocytosis 0.3822867487379637 0.59931285118932 0.5489642796600993 1.0 0.8554489205622365 14 Q06481,Q12907,Q4KMQ2,Q8WTV0,Q08722 5 +Positive regulation of renal sodium excretion 0.6699192462987973 0.5982441392908863 0.5496770434981906 1.0 0.8554489205622365 2 Q9Y5X3 1 +Renal sodium excretion 0.6699192462987973 0.5982441392908863 0.5496770434981906 1.0 0.8554489205622365 2 Q9Y5X3 1 +Regulation of renal system process 0.6699192462987973 0.5982441392908863 0.5496770434981906 1.0 0.8554489205622365 2 Q9Y5X3 1 +Renal tubular secretion 0.6699192462987973 0.5982441392908863 0.5496770434981906 1.0 0.8554489205622365 2 Q9Y5X3 1 +Gamma aminobutyric acid metabolic process 0.6695827725437515 0.5970142689394238 0.5504978540349619 1.0 0.8554489205622365 2 P51649 1 +Forebrain cell migration 0.4188095609685775 0.5950537333729008 0.5518075538511056 1.0 0.8554489205622365 10 Q9NQC3 1 +Insulin secretion 0.3244707857207458 0.5933681344615744 0.5529348096599507 1.0 0.8554489205622365 28 Q16836,Q8N183,Q12846,P00367,P53985,Q9BRT2,P40939,P04083,Q8N5M9,O95563,Q16822,P22466 12 +Insulin secretion involved in cellular response to glucose stimulus 0.4542567720673659 0.593256827815731 0.553009286467173 1.0 0.8554489205622365 8 Q8N183,Q12846,Q8N5M9 3 +Regulation of insulin secretion involved in cellular response to glucose stimulus 0.4542567720673659 0.593256827815731 0.553009286467173 1.0 0.8554489205622365 8 Q8N183,Q12846,Q8N5M9 3 +Regulation of morphogenesis of a branching structure 0.665570962839187 0.5925813452364667 0.5534613666144588 1.0 0.8554489205622365 3 Q9NQC3 1 +Ribonucleoside triphosphate metabolic process 0.3170171048772124 0.5921242757310728 0.5537673721480951 1.0 0.8554489205622365 35 P24539,Q9UJS0,P00846,Q8IWA4,O60313,Q9UJZ1,P56385,Q9NRA0,P00403,O75964 10 +Negative regulation of double strand break repair via nonhomologous end joining 0.6682368775235553 0.592103033573247 0.5537815956710632 1.0 0.8554489205622365 2 Q9UBB9 1 +Response to muramyl dipeptide 0.543712177850652 0.5909800598072366 0.5545337815751661 1.0 0.8554489205622365 4 Q16539 1 +Negative regulation of endoplasmic reticulum calcium ion concentration 0.6650013090974358 0.5905704464841196 0.55480827149635 1.0 0.8554489205622365 3 P51572 1 +Regulation of gliogenesis 0.3993381031160821 0.5902923047540897 0.5549946975834339 1.0 0.8554489205622365 11 Q96G23 1 +Post translational protein modification 0.393560743403631 0.5890064829570022 0.5558569247086655 1.0 0.8563746992386608 12 O75718,P46977,Q32P28,O60725 4 +Coenzyme a metabolic process 0.4175942332145947 0.5882314174057507 0.5563769721832976 1.0 0.8565366023769599 10 Q8WVC6,P35610 2 +Mitotic dna replication 0.4352777834139471 0.5860759441624455 0.5578244811137085 1.0 0.8574630846138173 9 O75844 1 +Negative regulation of nervous system development 0.3737296240656653 0.5850561624154236 0.5585099538507996 1.0 0.8575280071848801 15 P30536,Q9NQC3,Q96G23 3 +Tetrapyrrole biosynthetic process 0.398330966788292 0.5843049860141754 0.5590151382237578 1.0 0.8577732541707226 11 O75027,P22830,O00264 3 +Glutamine family amino acid biosynthetic process 0.4524612272420565 0.5842146734962902 0.5590758905242168 1.0 0.8577732541707226 8 P00367,P04181,Q53H96,O94925,P54886,Q96C36,O75746 7 +Negative regulation of cell projection organization 0.3253828390269946 0.5833950314313867 0.5596274018168885 1.0 0.8582037256136501 27 Q9NQC3,Q9NR77,Q96G23 3 +Macrophage activation 0.4642829952670716 0.5827258530524986 0.5600778664441319 1.0 0.8586111134044097 6 P05067,P14174 2 +Regulation of fat cell differentiation 0.4159511302030473 0.5790235161515135 0.5625733057406701 1.0 0.8604302008370702 10 Q16539,Q8N4Q0 2 +Positive regulation of potassium ion transmembrane transporter activity 0.5398038168049778 0.5752848934321729 0.5650986365245227 1.0 0.8628343847632808 4 P22466 1 +Trna aminoacylation for mitochondrial protein translation 0.4557083773639222 0.5699465195863991 0.5687139716625715 1.0 0.8664245460720784 7 Q6PI48,Q5JTZ9,Q5JPH6,Q9BW92 4 +Axis specification 0.4143007659362733 0.569793698293615 0.5688176301679202 1.0 0.8664245460720784 10 Q8N2A8,Q15363,Q5T9L3 3 +Cell activation involved in immune response 0.3142939135291074 0.5648748366795386 0.5721589002628729 1.0 0.8670239252405223 35 Q96FV9,Q9NQT5,P11279,Q12846,Q99584,P09601,O95219,P04083,Q9NRA0,P05067 10 +Positive regulation of calcium ion transport 0.3490494217370186 0.5645196199558694 0.572400551436826 1.0 0.8670239252405223 18 Q13586,O75323,P20020,P30536,O76024,Q9NRA0 6 +Bleb assembly 0.6574957210030019 0.5642563559809449 0.5725796791406479 1.0 0.8670239252405223 3 Q9NR77 1 +Reticulophagy 0.4602342989930436 0.5636530763155624 0.572990257605541 1.0 0.8670239252405223 6 Q86VR2,Q9Y3C8,Q9Y6I9 3 +Positive regulation of sodium ion transmembrane transport 0.4924216908049835 0.5635936293551471 0.5730307234187251 1.0 0.8670239252405223 5 O43707,P05026,P54709,Q9UHD1 4 +Regulation of mitotic cytokinesis 0.6598250336473784 0.5617147529577622 0.57431038111147 1.0 0.8672169161814494 2 Q9Y2S7 1 +Calcium mediated signaling 0.3630289323115933 0.55820771754116 0.5767025515162816 1.0 0.8696506316712571 16 O75844,P16615 2 +Serine family amino acid catabolic process 0.6556714910804379 0.5579129283515267 0.5769038428886808 1.0 0.8696506316712571 3 P23378,P34897 2 +Cellular response to fatty acid 0.4908839518660779 0.556897013214393 0.5775977954239562 1.0 0.8699671978152074 5 P50416,P11802 2 +Negative regulation of growth 0.3200132233015926 0.5524626648391743 0.5806314071406562 1.0 0.8718416601649814 28 Q9P0J0,Q13043,Q9NRA0,Q9NQC3,P50897,P35232 6 +Gpi anchor metabolic process 0.4566398236246546 0.5468118296934257 0.5845080150250617 1.0 0.8753802068992353 6 Q9H490,O43292 2 +Collagen biosynthetic process 0.5324777620566263 0.5461351818873573 0.5849730175789865 1.0 0.8754613436663804 4 Q92791 1 +L serine catabolic process 0.6554508748317676 0.5461297157331619 0.5849767747024133 1.0 0.8754613436663804 2 P34897 1 +Leukocyte differentiation 0.2957349211937799 0.5438666439309884 0.586533244153812 1.0 0.8763738297422803 53 P24390,P01889,Q16539,P55327,P04062,Q15904,O96005,P12956,P02786,P49327,Q8N5M9,P04083,Q14739,P05067,P05141 15 +Action potential 0.3661967009892366 0.534387596787987 0.5930733984940113 1.0 0.8799509553756144 15 P05023,P04062 2 +Sulfur compound biosynthetic process 0.3098432893447086 0.534077288648306 0.5932880621249663 1.0 0.8799509553756144 39 P35610,Q99735,Q8NCH0,Q53GQ0,Q9UMR5,Q8TB61,Q9NZ01,P50897,Q13126,O43505 10 +Negative regulation of epithelial cell apoptotic process 0.5292787378676054 0.5335228095744498 0.5936717258524666 1.0 0.8799509553756144 4 P09601 1 +Inflammatory cell apoptotic process 0.4851392516622329 0.5320275356629107 0.5947069244570962 1.0 0.8807687936856008 5 O75844 1 +I kappab kinase nf kappab signaling 0.2992554778628568 0.5318673166695852 0.59481789515706 1.0 0.8807687936856008 50 Q8IUH4,Q5T9L3,Q86UT6,O43657,P09601,Q8TB61,Q86UE4,P62942,Q9P035 9 +Regulation of protein secretion 0.3093656394180702 0.5291542522917632 0.5966984490240073 1.0 0.8820385894747705 39 Q16836,Q8N183,Q12846,P00367,Q96KC8,P53985,Q5T9L3,Q9H4A6,Q9BRT2,P40939,Q8N5M9,O95563,Q16850,P49755,Q16822,Q32P28 16 +Vascular endothelial growth factor receptor signaling pathway 0.4472307679647445 0.5290091773678341 0.5967990835341452 1.0 0.8820385894747705 7 P04792,P18031,Q16539,O75340 4 +Response to fatty acid 0.4067271959108981 0.5276963362762475 0.5977101165316316 1.0 0.8825251732107722 10 P50416,O00767,P11802,P23378,O15228 5 +Cerebral cortex cell migration 0.4241498804743594 0.5274597692160935 0.5978743470539889 1.0 0.8825251732107722 9 Q9NQC3 1 +Srp dependent cotranslational protein targeting to membrane 0.4240871445300364 0.5271318395590782 0.5981020375735446 1.0 0.882594085261683 9 Q9UHB9,Q9UGP8,Q15629 3 +Positive regulation of muscle tissue development 0.6465511249915055 0.5265202022345589 0.5985268192386701 1.0 0.8828096390866066 3 O75955 1 +Positive regulation of skeletal muscle tissue development 0.6465511249915055 0.5265202022345589 0.5985268192386701 1.0 0.8828096390866066 3 O75955 1 +Proline metabolic process 0.4521563342318067 0.5259334177160315 0.598934469242399 1.0 0.8830857179919295 6 P04181,Q53H96,P54886,P30038,Q96C36 5 +Response to progesterone 0.4829219602517412 0.5224934260734798 0.6013268224227302 1.0 0.885134014382548 5 Q969T9 1 +Endothelial cell proliferation 0.3577826068849492 0.5218811955507392 0.601753051833795 1.0 0.885134014382548 16 P09601,P57105 2 +Regulation of multicellular organism growth 0.3703009398977756 0.5211956758544674 0.6022304661467177 1.0 0.8852484021558968 14 O95470,Q99538,O75844,O43464,P05067,P50542 6 +Extrinsic apoptotic signaling pathway via death domain receptors 0.3873039227734441 0.5192674666337448 0.6035742370890707 1.0 0.8857175797913511 11 Q9NR28,Q13043,P09601 3 +Response to activity 0.3696504749637086 0.5169934849870209 0.6051607067667288 1.0 0.8865574343510318 14 Q16836,Q15388,P31930,P40939,O43819,Q9UDX5 6 +Hydrogen peroxide biosynthetic process 0.6437479692735608 0.5169832657687099 0.6051678405396281 1.0 0.8865574343510318 3 Q15067 1 +Dsrna processing 0.3630450923949618 0.5133468242083946 0.6077087354375106 1.0 0.8866501241355664 15 O75844,O75569,P22626 3 +Positive regulation of production of molecular mediator of immune response 0.3242762181000084 0.5124890439454619 0.6083087861569809 1.0 0.8871811645760885 22 Q9NQT5,Q12846,P14174,P02786,Q9NRA0,P35232,P04439 7 +Cardiac chamber development 0.3686937244658054 0.5108202728624753 0.6094769122022472 1.0 0.8877192315135449 14 Q6PI78 1 +Phagolysosome assembly 0.641871423763035 0.5106292437949261 0.60961069457014 1.0 0.8877192315135449 3 P61106,P51149 2 +Vesicle targeting to from or within golgi 0.3744034624434899 0.5071948441144616 0.6120181123051873 1.0 0.8896591880342729 13 Q15363,Q9NR31,P49755,Q9HCU5 4 +Regulation of immunoglobulin production 0.361527638476762 0.5032523869926603 0.614786837174121 1.0 0.8922507705608377 15 Q96FV9,Q12846,Q9NQT5,P02786,P35232 5 +Toll like receptor 3 signaling pathway 0.5205105370532356 0.4993403989274502 0.6175395993481505 1.0 0.8940964614010543 4 P41440,O75955 2 +Phagosome lysosome fusion 0.6416554508748346 0.4980150225748896 0.6184734538070722 1.0 0.8940964614010543 2 P51149 1 +Phagosome acidification 0.6416554508748346 0.4980150225748896 0.6184734538070722 1.0 0.8940964614010543 2 P51149 1 +Chemokine c c motif ligand 5 production 0.6413189771197871 0.4968620711749736 0.6192863199255856 1.0 0.8941532643718676 2 Q7Z434 1 +Positive regulation of chemokine c c motif ligand 5 production 0.6413189771197871 0.4968620711749736 0.6192863199255856 1.0 0.8941532643718676 2 Q7Z434 1 +Intestinal absorption 0.4348772457696291 0.496780220556712 0.6193440448403718 1.0 0.8941532643718676 8 Q16739 1 +Regulation of dna methylation 0.4399611452166458 0.4943210300207262 0.6210794753093083 1.0 0.8949509421340116 7 Q03164,O75844 2 +Carbohydrate derivative biosynthetic process 0.3341793430450598 0.4941945576779192 0.6211687829381676 1.0 0.8949509421340116 152 Q8NBX0,P35610,Q9UJS0,O43292,P09622,Q53GQ0,Q9H4A6,Q6ZXV5,Q9H3H5,Q96AA3,Q9NZ01,P00403,Q9H0U3,Q10472,P50897,Q13126,Q7LGA3,O75964,P46977,P00846,Q9H490,Q8N4A0,Q9HC07,Q9Y385,Q9NRA0,Q92643,P11177,Q9BT22,Q9BXS4,Q2TAA5,P24539,Q99805,Q8NCH0,Q8WVC6,Q9UMR5,P06865,Q9NQX7,Q9BV10,O43505,Q16739,Q86YN1,O15118,Q6Y1H2,Q9UJZ1,P56385,Q92542,Q8TB61,P53007 48 +Regulation of long chain fatty acid import across plasma membrane 0.6399730820996006 0.492260419071009 0.6225352572322937 1.0 0.8949509421340116 2 P31751 1 +Long chain fatty acid import across plasma membrane 0.6399730820996006 0.492260419071009 0.6225352572322937 1.0 0.8949509421340116 2 P31751 1 +Regulation of peptidase activity 0.2763112227035229 0.4908672020193639 0.6235203756684662 1.0 0.8950830681757836 73 Q96A26,Q99538,O43464,P07858,Q9NZJ7,O95831,P16435,Q96HY6,Q15418,O14737,P61289,P51572,P49755,Q15392,Q06481,Q9P0J0,P49327,P51812,P05067,O75915,Q15041,Q9BXK5,Q92542,Q9NR28 24 +Hindbrain morphogenesis 0.4327459694847774 0.4863368118950817 0.6267283833730084 1.0 0.8977324010069234 8 P04062 1 +Negative regulation of ion transmembrane transport 0.3647922531487846 0.4857452338261426 0.6271478082186603 1.0 0.8977324010069234 14 P21796,P62942,O75915 3 +Negative regulation of ion transport 0.3647922531487846 0.4857452338261426 0.6271478082186603 1.0 0.8977324010069234 14 P21796,P62942,O75915 3 +Negative regulation of hormone secretion 0.4325667533684748 0.4854603157281671 0.6273498562364088 1.0 0.8977324010069234 8 Q16836,P40939,Q8N5M9 3 +Negative regulation of peptide secretion 0.4325667533684748 0.4854603157281671 0.6273498562364088 1.0 0.8977324010069234 8 Q16836,P40939,Q8N5M9 3 +Organic hydroxy compound metabolic process 0.305110382963922 0.4836554781036648 0.6286303951233787 1.0 0.8986249120826438 111 O15269,O75477,P35610,Q15800,Q9H3H5,Q14849,Q10713,P07858,P04062,P16435,Q9NX62,Q9BW91,Q14534,Q14739,Q16850,P38435,Q9UBM7,Q15392,Q6NUM9,P37268,Q9BQE5,P35270,Q13510,P51648,Q8NBN7,O15118,P21964,P00374,Q8WTV0 29 +Regulation of histone h3 k14 acetylation 0.6336527655741717 0.4830972193136889 0.6290267083703829 1.0 0.8986249120826438 3 Q969T9 1 +Positive regulation of protein export from nucleus 0.4155849048471939 0.4829822156308322 0.6291083638652764 1.0 0.8986249120826438 9 P50402,Q05D32 2 +Regulation of cyclase activity 0.4427308096532332 0.4825440989635052 0.6294194792162513 1.0 0.89886663679778 6 Q16539 1 +Placenta development 0.3447748644001277 0.4792193609821533 0.6317825821138392 1.0 0.9008034880956076 17 Q15363,P35613,Q16539,Q13043 4 +Regulation of nervous system process 0.3974755942798478 0.4769163668119938 0.633421676892227 1.0 0.901736252384777 10 P05067,P04062 2 +Receptor signaling pathway via stat 0.3573164934768003 0.475371097077805 0.6345224916824908 1.0 0.9027277968641128 15 Q9NX40,Q9H490 2 +Immune response regulating signaling pathway 0.2943347676688653 0.4753385594189008 0.6345456794689652 1.0 0.9027277968641128 50 Q06481,Q86UT6,Q9UJZ1,O43657,Q08722,P46379,P04439,P41440,P51812,Q9NQC3,Q07666,Q9NUD5,P35232,Q07021,Q96J02,O75955 16 +Programmed necrotic cell death 0.3627772857929013 0.4728597204156428 0.6363132636739068 1.0 0.9034884320905142 14 Q13510,P12235 2 +Embryonic digit morphogenesis 0.4353765484821825 0.4726624094456835 0.6364540492710851 1.0 0.9034884320905142 7 Q9NX62 1 +Embryonic appendage morphogenesis 0.4353765484821825 0.4726624094456835 0.6364540492710851 1.0 0.9034884320905142 7 Q9NX62 1 +Cholesterol efflux 0.4135274555541638 0.4723909304810853 0.6366477767795145 1.0 0.9034884320905142 9 P35610,O15118,Q8WTV0 3 +Metencephalon development 0.3127073284614037 0.4698171622355646 0.6384856517369735 1.0 0.9052834833826604 27 P04062,Q92542,P54802,Q15058,O14949 5 +Acetyl coa biosynthetic process 0.4127740798268385 0.4685222733737475 0.6394111466451307 1.0 0.9056850217509766 9 P09622,P35610,P11177 3 +Regulation of generation of precursor metabolites and energy 0.304670072278023 0.4683653169777516 0.639523366157634 1.0 0.9056850217509766 34 Q9BSK2,Q9NZ45,P14406 3 +Appendage morphogenesis 0.4126905176238923 0.4680934935133478 0.6397177319836826 1.0 0.9056850217509766 9 Q9NX62 1 +Purine ribonucleoside metabolic process 0.4343895378410206 0.4680228980509604 0.6397682149147346 1.0 0.9056850217509766 7 O60725 1 +Ribonucleoside metabolic process 0.4343895378410206 0.4680228980509604 0.6397682149147346 1.0 0.9056850217509766 7 O60725 1 +Regulation of epithelial cell apoptotic process 0.4343891227651094 0.4680209487415526 0.6397696088927578 1.0 0.9056850217509766 7 O76024,P09601 2 +Positive regulation of interferon gamma production 0.511964269172787 0.4666066125001281 0.6407813551759625 1.0 0.9063071857646176 4 Q9NUQ9 1 +Response to ether 0.511720575512926 0.4656821465120858 0.6414430335438692 1.0 0.9065900180241128 4 Q14103,Q9H4A6 2 +Pteridine containing compound biosynthetic process 0.4334751802387428 0.4637324932828192 0.6428394141423688 1.0 0.90668372428026 7 P35270 1 +Positive regulation of synapse maturation 0.6312247644683762 0.46275503306994 0.6435399662939747 1.0 0.90668372428026 2 Q9UJX6 1 +Positive regulation of protein dephosphorylation 0.3726577623805231 0.4626381062433228 0.6436237897534853 1.0 0.90668372428026 12 P04062 1 +Positive regulation of sodium ion transport 0.4376684636118614 0.4595460513271518 0.6458420900543973 1.0 0.9081342616621736 6 Q9UHD1,P50570,O43707,P54709,P05026 5 +Isoprenoid metabolic process 0.3114168813495595 0.4583688584767022 0.6466874610440876 1.0 0.9089782706266464 27 Q8NBN7,Q6NUM9,P37268,Q9HB40,Q9H3H5,Q9BY49,P51648 7 +Gdp metabolic process 0.629542395693141 0.4571635747468282 0.6475534775113176 1.0 0.9095900842647888 2 Q00013 1 +Positive regulation of dna dependent dna replication 0.4671606601549328 0.4558628643016728 0.6484885951350885 1.0 0.910398587982305 5 Q9UJZ1,O95785,Q04837,O00311 4 +Locomotory behavior 0.3071346484649384 0.4527427134279776 0.6507340186939814 1.0 0.910398587982305 29 O15118,Q96RL7,P54802,O75844,Q8N2K0,P10253,P50897,P05067,P51790 9 +Histamine production involved in inflammatory response 0.5079924265777878 0.451603314191133 0.6515547820296281 1.0 0.910398587982305 4 P51809,O95219 2 +Histamine secretion 0.5079924265777878 0.451603314191133 0.6515547820296281 1.0 0.910398587982305 4 P51809,O95219 2 +Histamine transport 0.5079924265777878 0.451603314191133 0.6515547820296281 1.0 0.910398587982305 4 P51809,O95219 2 +Antigen processing and presentation of exogenous antigen 0.4255466868511997 0.4513411248693277 0.6517437092583487 1.0 0.910398587982305 8 P04439,Q03518,Q9UIQ6 3 +Positive regulation of myoblast fusion 0.4659354423031311 0.4507733273043581 0.6521529269555959 1.0 0.910398587982305 5 Q16539,O75955 2 +Regulation of myoblast fusion 0.4659354423031311 0.4507733273043581 0.6521529269555959 1.0 0.910398587982305 5 Q16539,O75955 2 +Unsaturated fatty acid biosynthetic process 0.3753338512656708 0.4499237419888129 0.6527654276575259 1.0 0.9108233965398508 11 P14174,O00767,O15121,O95864,P04083 5 +Negative regulation of endoplasmic reticulum stress induced intrinsic apoptotic signaling pathway 0.4351995976730274 0.4484134000561129 0.653854872709078 1.0 0.9113781756597616 6 O60313,O76024 2 +Negative regulation of alpha beta t cell activation 0.6229698908136411 0.4480692510086931 0.6541032188099689 1.0 0.9113781756597616 3 Q96J02 1 +Positive regulation of oxidoreductase activity 0.4248555029908867 0.4480052353259766 0.6541494182675511 1.0 0.9113781756597616 8 P00374,Q8WTV0 2 +Protein mannosylation 0.6227881907967394 0.4474812362542716 0.654527632787741 1.0 0.9115041885492062 3 Q6ZXV5 1 +Protein o linked mannosylation 0.6227881907967394 0.4474812362542716 0.654527632787741 1.0 0.9115041885492062 3 Q6ZXV5 1 +Odontogenesis 0.4240724069802565 0.4442310246966036 0.6568755638446067 1.0 0.9127674263995575 8 Q6P4Q7,P35613 2 +Endoplasmic reticulum localization 0.6210030292830634 0.4417183282817435 0.6586930450678845 1.0 0.9134895885518932 3 Q9BSJ8,A0FGR8 2 +Endoplasmic reticulum plasma membrane tethering 0.6210030292830634 0.4417183282817435 0.6586930450678845 1.0 0.9134895885518932 3 Q9BSJ8,A0FGR8 2 +Acylglycerol homeostasis 0.6208995350945004 0.4413850198674534 0.6589342852234836 1.0 0.9135251673828642 3 Q8WTV0 1 +Negative regulation of cell killing 0.5040706778914312 0.4369264088784406 0.6621647188830497 1.0 0.9156845747283424 4 P04439 1 +Mitochondrial transcription 0.4322878196242206 0.4353568502259735 0.6633034257262562 1.0 0.9156845747283424 6 Q9BSK2 1 +Golgi to plasma membrane transport 0.311496225662385 0.4334412120258714 0.6646942660237483 1.0 0.9156845747283424 25 Q8N668,Q9H4A6,Q8N2H4,P61026,Q4J6C6 5 +Regulation of er associated ubiquitin dependent protein catabolic process 0.5029344621268571 0.4327003448345197 0.6652324792750435 1.0 0.9156845747283424 4 P51572 1 +Positive regulation of endothelial cell chemotaxis 0.6179737462133827 0.4319987738556504 0.6657423043292685 1.0 0.9156845747283424 3 Q99538,P04792 2 +Regulation of endothelial cell chemotaxis 0.6179737462133827 0.4319987738556504 0.6657423043292685 1.0 0.9156845747283424 3 Q99538,P04792 2 +Tripartite regional subdivision 0.5024602058002636 0.4309399186759767 0.6665120570298932 1.0 0.9156845747283424 4 Q8N2A8 1 +Blastoderm segmentation 0.5024602058002636 0.4309399186759767 0.6665120570298932 1.0 0.9156845747283424 4 Q8N2A8 1 +Inflammasome complex assembly 0.6214670255720093 0.4307105556503889 0.6666788426817207 1.0 0.9156845747283424 2 O00571 1 +Pancreas development 0.3888677567398378 0.4304057941128634 0.6669004812756087 1.0 0.9156845747283424 10 Q5T9L3,O76024 2 +Regulation of cell aging 0.3659203066538318 0.422858172980325 0.6723987414645789 1.0 0.9163351069645508 12 O75844 1 +Histone h3 k14 acetylation 0.4294638873143715 0.4227725278842898 0.6724612331930855 1.0 0.9163351069645508 6 Q969T9 1 +Receptor metabolic process 0.2995603293309473 0.4185091648606889 0.6755748871870584 1.0 0.9178330626638848 34 P42892,Q99538,P49354,Q8NBU5,Q13636,P41440,P02786,Q9Y371,Q9UHD9,Q96J02,O75955 11 +Regulation of nik nf kappab signaling 0.3541583703746689 0.4182918256651374 0.6757337654718798 1.0 0.9178330626638848 14 P35232,P05067,O43657,Q99623 4 +Amyloid fibril formation 0.4184669493403534 0.4173840740622314 0.6763975018959287 1.0 0.9183408003666328 8 P10909,Q9UHV9,P61758,P62942,P05067 5 +Phosphatidylinositol dephosphorylation 0.4983044475145111 0.4156043459536361 0.6776995460158026 1.0 0.9191236617448318 4 Q10713 1 +Positive regulation of potassium ion import across plasma membrane 0.6133916554508807 0.404919952101319 0.6855363518661604 1.0 0.9238158905022004 2 P54709 1 +Regulation of potassium ion import 0.6133916554508807 0.404919952101319 0.6855363518661604 1.0 0.9238158905022004 2 P54709 1 +Pigment granule localization 0.4950470518486185 0.4037000469800402 0.6864333050536882 1.0 0.9243227997997012 4 Q13561 1 +Regulation of secretion 0.282500538187951 0.4024695213661741 0.6873385147344679 1.0 0.9244203946890586 89 P51151,Q9Y5X3,Q9H4A6,Q9BRT2,O00560,Q9P253,Q16836,Q96KC8,Q5T9L3,Q7L0J3,Q9NRA0,Q8N5M9,Q16850,P49755,Q32P28,P11279,P53985,Q12846,P14174,P16615,P40939,P61026,P22466,Q8N183,P09601,O95219,P04083,Q4J6C6 28 +Establishment or maintenance of transmembrane electrochemical gradient 0.6117092866756455 0.3996332307304781 0.6894266769307902 1.0 0.9259851946649792 2 P05026 1 +Positive regulation of glucose import 0.4534174656154658 0.3996003023349896 0.6894509337367842 1.0 0.9259851946649792 5 Q16625,Q16539 2 +Syncytium formation 0.4145442832047656 0.3987816002844946 0.6900541357396128 1.0 0.9261632056963574 8 Q14012,Q16539,O75955 3 +Regulation of mononuclear cell migration 0.3455252768582844 0.3984724207340643 0.690281983815892 1.0 0.9261632056963574 15 Q4KMQ2,Q8NHP6,Q07021,P05067,Q08722 5 +Modification of postsynaptic actin cytoskeleton 0.4932659932659902 0.3972353707004624 0.6911939013397581 1.0 0.9271042483564192 4 Q9UQB8,Q7L576,P35080 3 +Regulation of b cell mediated immunity 0.3982409097306683 0.3949866627129669 0.6928527309911647 1.0 0.9283464574511482 9 Q96FV9,Q9NQT5 2 +Regulation of isotype switching 0.3982409097306683 0.3949866627129669 0.6928527309911647 1.0 0.9283464574511482 9 Q96FV9,Q9NQT5 2 +L proline biosynthetic process 0.4520040417649027 0.3939218659687079 0.6936387262289427 1.0 0.9283602108962694 5 P04181,Q53H96,P54886,Q96C36 4 +Regulation of b cell activation 0.3447719350021426 0.3936247069038439 0.6938581374105577 1.0 0.9283602108962694 15 Q96FV9,Q9NQT5,P14174,Q9NPF0 4 +Positive regulation of sodium ion transmembrane transporter activity 0.4922558922558854 0.3935831710444286 0.6938888079863987 1.0 0.9283602108962694 4 O43707,Q9UHD1,P05026 3 +Epithelial cell apoptotic process 0.3818018542895878 0.3928320560997141 0.6944435267257756 1.0 0.9287100996005464 10 O76024,P09601,Q4KMQ2 3 +Positive regulation of exocytosis 0.3180120492880401 0.3904240056947883 0.6962230395721118 1.0 0.9301081728573026 19 P11279,P51151,Q12846,O95219,Q9NRA0,O00560 6 +Mitochondrion endoplasmic reticulum membrane tethering 0.603628032636464 0.3870332938942817 0.6987315600520385 1.0 0.931426813476366 3 P16615 1 +Positive regulation of long term synaptic potentiation 0.4903765000077839 0.3868154895355664 0.6988928091926288 1.0 0.931426813476366 4 Q99538,P05067 2 +Hindbrain development 0.2960237672167704 0.3862210926314972 0.6993329337294325 1.0 0.931426813476366 32 P04062,Q5T9L3,P54802,Q92542,Q15058,O14949 6 +Xenobiotic metabolic process 0.3963785208798035 0.3857264677835805 0.6996992585220507 1.0 0.931426813476366 9 O43169,P07099 2 +Activation of phospholipase d activity 0.6026765781235053 0.3841155537768064 0.7008928038999807 1.0 0.931426813476366 3 P18085 1 +Extrinsic apoptotic signaling pathway 0.2958985402666476 0.3836759816755907 0.7012186165153889 1.0 0.931426813476366 33 Q9P0J0,P09601,Q9NQX7,P49327,Q13043,P30154,Q9NR28 7 +B cell activation 0.2976247712195675 0.3836046169601071 0.7012715175170585 1.0 0.931426813476366 30 Q96FV9,Q9NQT5,P14174,P55327,P02786,P35232,Q9NPF0,P05141 8 +Positive regulation of cell activation 0.2946587228823852 0.3791389823025047 0.7045846597604142 1.0 0.9318329057759932 39 Q14254,Q9NQT5,P11279,Q12846,P14174,O95219,P12956,Q9NUQ9,P02786,Q15418,Q9NRA0,P04083,P04439,Q9NPF0,Q08722 15 +Response to hepatocyte growth factor 0.4881629494287499 0.3788911799775047 0.7047686741172812 1.0 0.9318329057759932 4 Q06481 1 +Negative regulation of cyclin dependent protein serine threonine kinase activity 0.4875420875420769 0.3766777312138445 0.7064131138704419 1.0 0.9318329057759932 4 O00410,P53350,O95373 3 +Regulation of myotube differentiation 0.4476067466661285 0.3763929166152236 0.7066248112196913 1.0 0.9318329057759932 5 Q9BYT8,Q16539 2 +Regulation of fc receptor mediated stimulatory signaling pathway 0.6001121718364305 0.376292952605989 0.7066991179743596 1.0 0.9318329057759932 3 Q08722 1 +Negative regulation of macroautophagy 0.3622982143842809 0.376250434771113 0.7067307238197944 1.0 0.9318329057759932 11 P09601 1 +Negative regulation of cell development 0.3231733208293165 0.3755110301696727 0.7072804447418282 1.0 0.9318329057759932 18 P30536,Q9NQC3,Q96G23 3 +Regulation of viral induced cytoplasmic pattern recognition receptor signaling pathway 0.3942948704139207 0.3754139285493718 0.7073526476751213 1.0 0.9318329057759932 9 Q86UT6,O43657,Q9NUD5 3 +Regulation of tolerance induction 0.59979728246989 0.3753365954149132 0.7074101530180983 1.0 0.9318329057759932 3 Q96J02 1 +Tolerance induction 0.59979728246989 0.3753365954149132 0.7074101530180983 1.0 0.9318329057759932 3 Q96J02 1 +Cellular response to mineralocorticoid stimulus 0.5992183019153117 0.3735805737914525 0.7087163890328672 1.0 0.932974169526474 3 O95831 1 +Pyridine containing compound metabolic process 0.4090248538666582 0.3728819861648882 0.7092362796595406 1.0 0.932974169526474 8 P43490 1 +Maintenance of protein location 0.2983341203784386 0.3725643886047713 0.7094726813422629 1.0 0.932974169526474 29 P24390,Q5THJ4,O43292,Q9UH99,P30536,Q9H4A6,O15258,P52789 8 +B cell proliferation 0.4135968949726026 0.3724456150071595 0.7095610968869064 1.0 0.932974169526474 7 P02786,P14174,Q9NPF0 3 +Regulation of lipid biosynthetic process 0.2994697016278689 0.3672182356647805 0.7134562380030913 1.0 0.937123215374162 28 Q13510,Q8NF37,Q92604,P16435,P30536,P04083,Q8WTV0,Q9UBM7,P05023,O75477 10 +Regulation of ion transmembrane transport 0.2757832487224605 0.3637784380503888 0.7160234650330253 1.0 0.939326703455004 56 Q9BVC6,Q8N668,P0CG08,Q13586,P21796,O00483,Q9NRA0,Q8TAD4,P08183,P27105,O75844,P05067,P22466,O75915,Q15041,O75323,Q4KMQ2,P62942,Q99623 19 +Regulation of cell cell adhesion mediated by cadherin 0.4836234592709731 0.3628017989321918 0.716752947960094 1.0 0.9398944163376518 4 O75955 1 +Positive regulation of cell cell adhesion mediated by cadherin 0.4836234592709731 0.3628017989321918 0.716752947960094 1.0 0.9398944163376518 4 O75955 1 +Bone resorption 0.4155755012910682 0.3620941394524182 0.7172816829707238 1.0 0.9401063396041616 6 O14773 1 +Secretion 0.3208275543153553 0.3603835976360958 0.7185602909286319 1.0 0.9404918898224178 147 Q7Z6M1,P51151,Q9Y5X3,Q13636,Q9H7Z7,Q9H4A6,Q9BRT2,P35670,P00403,P50897,Q86YV9,O00560,Q9P253,Q16836,Q96KC8,Q5T9L3,Q7L0J3,P27824,Q9BRK5,Q9NRA0,Q8N5M9,Q16850,P49755,Q96PC5,Q32P28,Q13505,P53985,P11279,Q12846,P14174,Q99584,Q8TBQ9,P16615,P40939,P61026,O15498,P52789,P22466,Q8N183,Q9HCU5,P55327,P62820,P09601,O95219,P04083,Q15758,Q9UBV2,O43760,Q4J6C6 49 +Methionine biosynthetic process 0.4434489561254084 0.3600158508108629 0.7188352800252671 1.0 0.9404918898224178 5 Q13126,Q9UHY7 2 +Sulfur amino acid biosynthetic process 0.4434489561254084 0.3600158508108629 0.7188352800252671 1.0 0.9404918898224178 5 Q13126,Q9UHY7 2 +Leukocyte homeostasis 0.391125297655634 0.3598268260997699 0.7189766407159746 1.0 0.9404918898224178 9 P49327,P14174 2 +Positive regulation of fibroblast migration 0.5946409421088767 0.3598088421768692 0.7189900903567434 1.0 0.9404918898224178 3 O95429 1 +Peripheral nervous system axon regeneration 0.4825872824547553 0.3591603367102771 0.7194751464208673 1.0 0.9409320917787354 4 P30536,Q96G23 2 +Midbrain development 0.3203996013424168 0.3558538027375605 0.7219500541153938 1.0 0.9414985667893732 18 Q5T9L3,Q16352,P24539,O14949 4 +Neuron projection regeneration 0.3738612129280955 0.3513398312846446 0.7253334161646974 1.0 0.9426554918521872 10 Q96G23,P00374,P30536,P07196 4 +Negative regulation of response to endoplasmic reticulum stress 0.3432173512133285 0.3504924474020435 0.7259691572430131 1.0 0.9428074233568036 14 O60313,Q96HY6,P10909,O95881,O76024 5 +Morphogenesis of a branching structure 0.3320124911819297 0.3483384223080252 0.7275860417167084 1.0 0.9437428133494042 16 Q15363,Q9NQC3 2 +Response to topologically incorrect protein 0.2789593041682101 0.3456797916691152 0.7295833729796677 1.0 0.9439702567495704 53 Q15363,P57088,Q6NTF9,Q9Y4P3,Q9GZP9,P46379,O76024,Q15629,Q9BUN8 9 +Ganglioside catabolic process 0.5893414388199854 0.3441159343283421 0.730759100019146 1.0 0.9439702567495704 3 P17900 1 +Ganglioside metabolic process 0.5893414388199854 0.3441159343283421 0.730759100019146 1.0 0.9439702567495704 3 P17900 1 +Oocyte construction 0.589283137478542 0.3439448209032729 0.7308877836395649 1.0 0.9439702567495704 3 Q8N2A8 1 +Indole containing compound metabolic process 0.5921938088829138 0.340601562187515 0.7334035532430536 1.0 0.9458636502844588 2 Q92947 1 +Intracellular lipid transport 0.3492293234948168 0.3268989371412051 0.7437443250023816 1.0 0.952567500711504 12 P50416,O15118,O43772,P23786,P28288 5 +Monocyte chemotaxis 0.4033057120905947 0.3268819773731751 0.7437571529207032 1.0 0.952567500711504 7 P04083,Q8NHP6,Q4KMQ2 3 +Blood vessel endothelial cell migration 0.3092425388021326 0.3259868974464729 0.7444342684548695 1.0 0.953110568039935 19 P42785,P09601,Q16539,Q8WTV0 4 +Regulation of neutrophil chemotaxis 0.4028253402320991 0.3247869162455755 0.7453423475135756 1.0 0.9535259450899076 7 Q07021,Q8NHP6 2 +Memory 0.4025233411941736 0.3234713078713809 0.7463383335340039 1.0 0.9536210857075262 7 Q99538,O00264,Q8NBU5 3 +Regulation of nitric oxide metabolic process 0.3524592339997272 0.322179409729205 0.7473167821993187 1.0 0.9541840369414644 11 P06280,P30536,Q92945,Q08722 4 +Positive regulation of glucose transmembrane transport 0.4060829732023323 0.3218999454886714 0.747528494485237 1.0 0.9541840369414644 6 Q16539 1 +Signal transduction in absence of ligand 0.3517738733801482 0.3184682692655628 0.7501297601279813 1.0 0.9556867068791042 11 O43464,P49327,P30154,Q07820 4 +Protein k11 linked ubiquitination 0.3824808640010082 0.3179672054620743 0.7505098131668746 1.0 0.9556867068791042 9 Q9UJX6,Q9UJX3,Q9UJX4,Q13042 4 +Regulation of monooxygenase activity 0.3824781803558076 0.3179543657862931 0.7505195527582547 1.0 0.9556867068791042 9 P06280,P00374,Q8WTV0 3 +Lipid export from cell 0.4703328810948083 0.3170106490006276 0.751235521957831 1.0 0.9560844262118464 4 P14174 1 +T cell differentiation 0.2998788062202167 0.3163964418654039 0.7517016173374187 1.0 0.9564229254534138 22 P24390,P04062 2 +Positive regulation of ubiquitin protein ligase activity 0.4317952172448622 0.3151997376292041 0.7526100047599213 1.0 0.956854448197648 5 Q12834,P63208,P53350,Q96GX5 4 +Fc gamma receptor signaling pathway 0.5746338532691169 0.3020417745635578 0.7626202177092296 1.0 0.9631708084124494 3 Q08722 1 +Ovulation cycle 0.4011415027810422 0.3014298872088558 0.7630867067753881 1.0 0.9631708084124494 6 O95470 1 +Regulation of striated muscle cell differentiation 0.3931220498988353 0.3002585252637978 0.7639799664999432 1.0 0.963869940683442 8 Q16539,P67809,Q13547,P42345,Q9BYT8,O94826,P11413 7 +Interferon beta production 0.3443394218627413 0.2995981166712772 0.7644837209036159 1.0 0.963869940683442 12 Q86UT6,P41440,O75955 3 +Negative regulation of immune system process 0.2848245426759167 0.2986307708100624 0.7652217844907112 1.0 0.9641046479592608 43 Q96FV9,P01889,P14174,Q16539,Q86UT6,P09601,P04439,P04083,Q7Z739,P28070,P38646,Q96J02,Q08722 13 +Regulation of extrinsic apoptotic signaling pathway via death domain receptors 0.3920528564631882 0.2954921411888318 0.7676179548927275 1.0 0.9652404928518916 8 Q13043,P09601 2 +Positive regulation of epithelial cell proliferation 0.3117407510480156 0.2954567511273117 0.7676449859670713 1.0 0.9652404928518916 18 Q9NQC3 1 +Collagen metabolic process 0.3628667620711059 0.2953381072625813 0.7677356087001723 1.0 0.9652404928518916 10 P08670,Q92791,P07858 3 +Lipid metabolic process 0.3838156295872129 0.293467416641863 0.7691649013903281 1.0 0.965839375680422 277 Q8NBX0,Q53H12,Q92604,Q8NCC3,Q15800,Q9H7Z7,Q8N2K0,O14735,P50897,Q16836,Q96DA6,P04062,P07602,Q9HB40,Q9NTJ5,Q9NRA0,Q92643,Q15392,Q16880,Q8N2A8,Q9BQE5,O75844,Q8N4Q0,Q9H6K4,Q9H6V9,Q13510,P51648,Q16739,Q86YN1,Q8NF37,A1L0T0,P21964,Q9P035,Q9NUQ2,Q96G23,O95470,Q9H3H5,Q14849,Q9NZ01,Q9H490,Q9NZJ7,P17900,Q8NHP8,Q14534,Q14739,Q16850,Q9BT22,P53985,O14773,P37268,P23786,Q9BV10,Q8NBN7,P27544,O15118,Q9BWD1,O15121,Q15067,O95674,Q8WTV0,Q96N66,O15269,P35610,Q53GQ0,Q96AA3,Q10713,P05023,P16278,Q16539,Q99735,Q9NX62,P38435,Q9UG56,Q99805,O00767,Q8NBQ5,P07099,P06280,P49327,Q6Y1H2,O14880,Q06136,Q9UBV2,Q8IY17,O75477,P17050,O43292,O95864,Q8WUK0,O43681,P16435,P30536,Q9UBM7,O00116,Q2TAA5,P14174,Q6NUM9,O15254,P06865,P40939,Q9BY49,Q9UBF8,Q9UJZ1,O43808,P04083,Q9Y394 106 +Excretion 0.4258808201164832 0.2931078981033054 0.7694396799569145 1.0 0.965992939462357 5 P09601 1 +Regulation of neutrophil migration 0.3913488746528838 0.2923623874215071 0.7700095630025887 1.0 0.9663253925557448 8 Q07021,Q8NHP6 2 +Response to corticosteroid 0.2944580762660367 0.2911897246110337 0.7709062208154358 1.0 0.9670675067060962 25 P20020,P04062,P07196,O95831,P16435,P04083,Q16822,P16278 8 +Positive regulation of protein localization to membrane 0.2944113403082294 0.2908082528229366 0.7711979731678167 1.0 0.9671449931092696 25 O00264,P27105,O15258,O14737 4 +Negative regulation of response to biotic stimulus 0.2968051369791903 0.2878813534955645 0.7734375607310944 1.0 0.9694750588111364 20 P01889,Q86UT6,O43657,P04439,Q7Z739,Q96J02 6 +Positive regulation of wound healing 0.3937134915737466 0.2856233912207778 0.775166585875074 1.0 0.970864898045527 7 Q16625,P04083,P05556,Q4KMQ2 4 +Spermatid differentiation 0.3032072666966959 0.2825792760878454 0.7774993683975169 1.0 0.9724787536267568 19 Q8N2A8,P09622,A0AVF1 3 +Cellular response to corticosteroid stimulus 0.3448835408687395 0.2815926708322651 0.7782558607147929 1.0 0.9726279103626382 11 O95831,P20020,P04083,Q16822 4 +Purine containing compound biosynthetic process 0.2583861732442234 0.2804507126614906 0.7791317342928155 1.0 0.97317677157744 70 P24539,P35610,Q9UJS0,P00846,Q53GQ0,Q8WVC6,Q9UMR5,Q8TB61,Q9NZ01,P50897,Q13126,O75964 12 +Response to retinoic acid 0.3446334422116317 0.2802696077399962 0.7792706662471998 1.0 0.97317677157744 11 P02786,Q9P0J0,Q99623 3 +Neuron maturation 0.4218292746815026 0.2782435639921396 0.780825395424714 1.0 0.9735250180717204 5 Q9NZJ7 1 +Regulation of ribosome biogenesis 0.56965006729476 0.2780532906720032 0.7809714509614023 1.0 0.9735250180717204 2 Q5T3I0 1 +Response to zinc ion 0.4207472405385065 0.2743119278124817 0.7838449188898795 1.0 0.9754019997951808 5 Q8TAD4 1 +Interleukin 1 production 0.3732011402751218 0.2741897315009857 0.7839388189240504 1.0 0.9754019997951808 9 P04083,P49755,Q99584 3 +Establishment of protein localization to plasma membrane 0.2939050913823156 0.2741885824242905 0.7839397019307832 1.0 0.9754019997951808 23 Q8N2H4,Q15904,P61026,Q9H4A6 4 +Long term synaptic potentiation 0.3585003937923956 0.2736142009524859 0.7843811195497215 1.0 0.9754019997951808 10 Q99538,Q12846,P05067,Q92542 4 +Organic hydroxy compound transport 0.2842200998218689 0.2733931578331728 0.7845510117817267 1.0 0.9754019997951808 33 P53985,P35610,O15118,P30536,P10909,Q86Y82,Q14849,P28288,P22466,Q8WTV0 10 +Myeloid leukocyte cytokine production 0.3868320299674667 0.2724465933682644 0.785278650792294 1.0 0.975630565359714 8 P09601 1 +Negative regulation of type i interferon production 0.4198437341706405 0.2710414926281822 0.7863591197425102 1.0 0.9767813771703532 5 Q86UT6 1 +Regulation of collateral sprouting 0.5631100639515167 0.270675618969226 0.7866405302666677 1.0 0.9769393764437052 3 P53990,Q15375 2 +Macroautophagy 0.2845963487419215 0.2693001598566933 0.7876987091748144 1.0 0.9774870367526836 105 O15269,Q9Y5X3,O43464,Q9Y371,P13473,Q86VR2,P05141,P21796,P04062,Q96HY6,Q9UHD9,Q16543,P61421,Q9Y487,P16615,Q9Y6I9,Q93050,Q5THJ4,P27544,P54646,O15118,O75396,P62820,Q9H0U4,Q96GC9,P09601,O95219,Q86Y82,P53365,Q9Y3C8,P12235,Q99623 32 +Protein quality control for misfolded or incompletely synthesized proteins 0.3573008018495822 0.2677010176839391 0.788929466398335 1.0 0.9784752551274122 10 P36776,Q16740,P46379,Q9BUN8 4 +Receptor mediated endocytosis 0.2708181029978763 0.2676634035102718 0.7889584219717161 1.0 0.9784752551274122 54 Q7Z6M1,Q9UBF8,Q5VW38,P27824,Q8NBU5,Q14108,Q13636,P10909,P41440,Q13432,P02786,Q9UHD9,P50897,P05067,O75955 15 +Response to muscle activity 0.4182815762737462 0.2654140286924065 0.7906905302539584 1.0 0.9796644844824616 5 Q15388,Q9UDX5 2 +Dna methylation 0.3241434421276351 0.2646197385753302 0.7913024128514001 1.0 0.9800748296707054 15 Q8N2A8,Q8NB78,Q03164,O75844 4 +Positive regulation of blood vessel endothelial cell migration 0.37112702239896 0.2645824554361687 0.7913311371374361 1.0 0.9800748296707054 9 P09601,Q16539 2 +Sprouting angiogenesis 0.3564810675655491 0.2636743017405639 0.7920308991867935 1.0 0.9804505272689508 10 P09601 1 +Regulation of exocytosis 0.2823674002468917 0.2634941796181056 0.7921697090906656 1.0 0.9804505272689508 41 P11279,P51151,Q12846,P09601,P16615,O95219,P04083,Q9NRA0,P61026,Q9P253,Q4J6C6 11 +Positive regulation of mitochondrial membrane potential 0.4537891126199424 0.2629837733129288 0.7925630860527699 1.0 0.9804505272689508 4 Q9UJZ1,Q8IWA4 2 +Positive regulation of membrane potential 0.4537891126199424 0.2629837733129288 0.7925630860527699 1.0 0.9804505272689508 4 Q9UJZ1,Q8IWA4 2 +Negative regulation of collateral sprouting 0.5629205921938182 0.260636482371692 0.7943728529197625 1.0 0.9815765270430288 2 Q15375 1 +C21 steroid hormone biosynthetic process 0.5592371550414794 0.2604644807441805 0.794505510245952 1.0 0.9815765270430288 3 Q14849 1 +Cellular response to dsrna 0.3840661959662143 0.2603965275861549 0.7945579211802134 1.0 0.9815765270430288 8 O75955,Q9NUD5 2 +Natural killer cell mediated immunity 0.3699550349019805 0.2591838873328771 0.7954933624864349 1.0 0.98228412911259 9 P11279,P01889,P04439 3 +B cell mediated immunity 0.3231628448473405 0.2586909073352584 0.7958737357147512 1.0 0.98228412911259 15 Q96FV9,Q9NQT5,Q07021,P02786 4 +Regulation of anoikis 0.4522298572255834 0.2580737973251414 0.7963499534701588 1.0 0.98228412911259 4 Q07820,Q9Y3E5 2 +Nucleoside triphosphate metabolic process 0.2812355745811502 0.2565898824911325 0.7974953861791314 1.0 0.982331960226482 42 P24539,Q9UJS0,P00846,Q8IWA4,O60313,Q9UJZ1,P56385,Q9NRA0,P00403,Q9H773,O75964 11 +Granulocyte chemotaxis 0.3320135016229529 0.2551656709177201 0.7985951442596937 1.0 0.9824820226507937 13 P04083,P35613,Q8NHP6 3 +Regulation of transcription elongation from rna polymerase ii promoter 0.339463736237691 0.2531763853959284 0.800131913900302 1.0 0.9829741812534968 11 Q8IXH7 1 +Response to manganese ion 0.4148399902529281 0.2531391482690016 0.800160687851889 1.0 0.9829741812534968 5 P05067,P30536 2 +Copii coated vesicle cargo loading 0.3536018501099085 0.2496229598844098 0.8028789411526964 1.0 0.9839887970985358 10 Q9NR31,Q15436,Q15437 3 +Aspartate family amino acid metabolic process 0.2914763976710165 0.2485747139878678 0.8036897699739187 1.0 0.9843721491807134 20 Q13126,Q9BQT8 2 +Rna interference 0.3843330213374161 0.2465260778858138 0.8052750199992769 1.0 0.9846867837028463 7 O75569 1 +Negative regulation of vascular endothelial growth factor receptor signaling pathway 0.5535309897536175 0.2457316376493705 0.8058899796621868 1.0 0.9846867837028463 3 P18031 1 +Endothelial cell chemotaxis 0.4125968339508237 0.2452313167277291 0.8062773293207248 1.0 0.9846867837028463 5 Q99538,P04792,Q9NWH9,P51153 4 +Fc receptor mediated stimulatory signaling pathway 0.4468027294577962 0.2412405713152285 0.8093686679004439 1.0 0.9846867837028463 4 Q08722 1 +Regulation of myoblast differentiation 0.5516895403404285 0.2410576171363645 0.8095104608562627 1.0 0.9846867837028463 3 Q16539 1 +Positive regulation of bone mineralization 0.5510201594371338 0.2393684023950837 0.8108199291355127 1.0 0.9853336372671154 3 Q4KMQ2 1 +Positive regulation of biomineralization 0.5510201594371338 0.2393684023950837 0.8108199291355127 1.0 0.9853336372671154 3 Q4KMQ2 1 +Positive regulation of synaptic transmission 0.309136308842253 0.2375265516112337 0.8122483232855535 1.0 0.9866909162059408 17 Q12846,Q99538,Q92542,P41440,P05067,O75955 6 +Positive regulation of extrinsic apoptotic signaling pathway 0.3358659881823279 0.234620303809626 0.8145034492181182 1.0 0.9879122094575336 11 Q9NQX7,O43464,P30154,Q13043 4 +Post golgi vesicle mediated transport 0.2785127810923278 0.234221340678581 0.8148131482897574 1.0 0.9879122094575336 43 P11279,Q8N668,Q96RL7,Q13636,Q9H4A6,Q8N2H4,P61026,O14828,O15127,Q4J6C6 10 +Smad protein signal transduction 0.3634604329424535 0.2296752658594856 0.8183441161276035 1.0 0.9904276220816032 9 O00400,Q9UIQ6 2 +Positive regulation of nuclear transcribed mrna catabolic process deadenylation dependent decay 0.5461792211523563 0.2273093952200182 0.82018316798337 1.0 0.9916808154263168 3 Q9H2U1 1 +Positive regulation of cell adhesion molecule production 0.5461594122574163 0.2272606218361626 0.8202210912250465 1.0 0.9916808154263168 3 O75955 1 +Regulation of endothelial cell migration 0.2872247513115327 0.2269669897155047 0.8204494107326463 1.0 0.9916808154263168 24 P42785,Q16539,P09601,P57105,Q8WTV0 5 +Leukocyte apoptotic process 0.3009239332850366 0.2223769383739224 0.8240204629018524 1.0 0.993750167996047 18 P49327,P24390,P14174 3 +Phosphatidylcholine metabolic process 0.3257912450693658 0.2207567577684059 0.8252818351790294 1.0 0.9944087987483096 13 Q96N66,Q8IY17,Q8NF37,Q8WTV0 4 +Er associated misfolded protein catabolic process 0.3807515857285122 0.2206413651371848 0.8253716899855519 1.0 0.9944087987483096 6 Q9BUN8 1 +Lymphocyte homeostasis 0.3778940457356489 0.2204657739621425 0.8255084250382572 1.0 0.9944087987483096 7 P49327 1 +Response to molecule of bacterial origin 0.2781329282436789 0.219948688346267 0.8259111168307816 1.0 0.99470473861654 32 P14174,Q16539,P30536,Q9NUQ9,Q86UE4,P08670,Q8WTV0 7 +Production of molecular mediator of immune response 0.278448351896888 0.2182219522311238 0.8272561818162514 1.0 0.995000552839558 34 Q96FV9,Q9NQT5,Q12846,P14174,P09601,P02786,Q9NRA0,P35232,P04439 9 +Negative regulation of t cell proliferation 0.4046699528118497 0.2178916927556695 0.8275134998715161 1.0 0.9951211126966696 5 Q96IZ0,Q96J02 2 +Embryonic brain development 0.3797169811320782 0.2167127225021088 0.8284322324952864 1.0 0.9958478544321896 6 Q9BVA1,P62995,O60508,P27635,Q9Y3C6 5 +Positive regulation of dephosphorylation 0.3247346294762731 0.214996555625948 0.8297700039838185 1.0 0.9970775749691748 13 P04062 1 +Regulation of cytoplasmic mrna processing body assembly 0.5404122142955294 0.2133089254516447 0.831086012253853 1.0 0.997369032958636 3 Q9NZN8 1 +Regulation of receptor binding 0.5403399330837321 0.2131359995902555 0.8312208860762764 1.0 0.997369032958636 3 P16615 1 +Negative regulation of inflammatory response to antigenic stimulus 0.4030859824684961 0.2125447475281708 0.831682071668713 1.0 0.997369032958636 5 P28070,Q16539 2 +Positive regulation of atp metabolic process 0.3785930811922185 0.2124648816545909 0.8317443727104141 1.0 0.997369032958636 6 P05067,P00403,O75746 3 +Positive regulation of nucleotide metabolic process 0.3785930811922185 0.2124648816545909 0.8317443727104141 1.0 0.997369032958636 6 P05067,P00403,O75746 3 +Regulation of action potential 0.3726171295469014 0.2117662280006677 0.8322894171081723 1.0 0.9978337353104224 8 P04062 1 +Intermembrane lipid transfer 0.3755178267159602 0.2110174344067704 0.8328736669728813 1.0 0.998252906122076 7 Q14849 1 +Regulation of receptor mediated endocytosis 0.2851562247688758 0.2109142289887584 0.8329542007515855 1.0 0.998252906122076 24 Q8NBU5,P10909,P41440,Q13432,Q9UHD9,P50897,P05067,O75955 8 +Positive regulation of histone acetylation 0.3779816230790593 0.2101626009783282 0.8335407677801983 1.0 0.99857805671096 6 Q969T9 1 +Histone h2a acetylation 0.3751844648751965 0.2096993975922599 0.8339022957329567 1.0 0.9988222808599512 7 Q9NRA0,Q86UY6 2 +Cell proliferation in forebrain 0.4357160716319855 0.2081332419333439 0.8351249321527374 1.0 0.9993419805794468 4 Q15058 1 +Modification of postsynaptic structure 0.37702156334232 0.2065602967122506 0.8363532701160854 1.0 1.0 6 Q7L576,P07737,Q9UQB8,P35080,O95793 5 +Cell cell adhesion mediated by integrin 0.5400403768506166 0.2059796252757044 0.8368068267160287 1.0 1.0 2 P05556 1 +Glucocorticoid metabolic process 0.4344240429138516 0.2043902552732868 0.8380485446227803 1.0 1.0 4 P05023 1 +Sulfur compound catabolic process 0.3573906582735455 0.2027524960152181 0.8393284893424855 1.0 1.0 9 P35610 1 +Cellular response to retinoic acid 0.3701411555269427 0.2015291876142722 0.8402848091645942 1.0 1.0 8 Q9P0J0,Q99623 2 +Positive regulation of extrinsic apoptotic signaling pathway in absence of ligand 0.3979488518177991 0.1954782515425481 0.8450185620095303 1.0 1.0 5 O43464,P30154 2 +Sertoli cell differentiation 0.5324806462470437 0.1947151640551912 0.8456159399315739 1.0 1.0 3 Q14151,P51659 2 +Digestion 0.3278274173405358 0.1941099198333717 0.8460898144527735 1.0 1.0 11 Q16739 1 +Protein kinase b signaling 0.2829215504636564 0.1937199030398099 0.8463952066806391 1.0 1.0 24 Q86UE4 1 +Neuron projection guidance 0.2900711156138391 0.1912650439293824 0.8483179463885795 1.0 1.0 19 P35613,O00264 2 +Positive regulation of inflammatory response 0.3200745180486143 0.1898939307676966 0.8493922484849452 1.0 1.0 13 Q08722,O95219,Q99735,P33527 4 +Sertoli cell development 0.5323014804845284 0.1891346254469649 0.8499873040316555 1.0 1.0 2 P51659 1 +Regulation of post translational protein modification 0.5300289206388131 0.1891250251525841 0.8499948281780225 1.0 1.0 3 O75718 1 +Regulation of cholesterol metabolic process 0.3697359370687609 0.1884240972505155 0.8505442111293631 1.0 1.0 7 P16435,O75477 2 +Negative regulation of cysteine type endopeptidase activity 0.3063433803409803 0.187255381030852 0.8514604049032752 1.0 1.0 16 Q15041,P16435,Q15392 3 +Protein destabilization 0.3402158948251783 0.1863055824660772 0.8522051299324769 1.0 1.0 10 Q8WU17 1 +Negative regulation of cellular response to insulin stimulus 0.39511712504949 0.1862538308479281 0.8522457115130391 1.0 1.0 5 Q06481 1 +C21 steroid hormone metabolic process 0.4275463753151368 0.1848834903148678 0.8533204205709468 1.0 1.0 4 Q14849 1 +Negative regulation of cell activation 0.3058371303568888 0.1842351724443629 0.8538289680968298 1.0 1.0 16 Q96FV9,P04083,Q96J02,P09601 4 +Regulation of mitochondrial fission 0.3529325824433905 0.1834058804747694 0.8544795621768588 1.0 1.0 9 Q9Y3D6,Q9NUQ9,Q9NX47,P11233 4 +Lymphocyte activation 0.2635934187380839 0.1825371821955563 0.8551611773161796 1.0 1.0 86 Q9NQT5,P46379,P0CG08,Q9NUQ9,Q9NPF0,P05141,P24390,P04062,P35232,Q96FV9,P11279,Q9BXW9,P14174,O96005,P12956,Q9NRZ9,Q96J02,P22466,Q14254,P55327,Q9UJZ1,Q92542,P02786,P04083,P62942,P04439,Q99623,Q08722 28 +Apical protein localization 0.4266123003868353 0.1822892067481541 0.8553557685452144 1.0 1.0 4 P18085,Q9HD26 2 +Inositol phosphate catabolic process 0.370186517941945 0.181366634530272 0.8560798063260648 1.0 1.0 6 Q10713 1 +Negative regulation of striated muscle cell differentiation 0.4259259259259104 0.1803913651653536 0.8568453327302863 1.0 1.0 4 P11413,O94826,P67809 3 +Nucleoside triphosphate biosynthetic process 0.273703587314683 0.1801711063749054 0.8570182409892204 1.0 1.0 32 P24539,Q9UJS0,P00846,Q9UJZ1,P56385,Q9NRA0,P00403,O75964 8 +Negative regulation of voltage gated calcium channel activity 0.5272543741588273 0.1786048227462986 0.8582480073801686 1.0 1.0 2 P0DP25 1 +Regulation of calcium ion transport 0.2746118462941395 0.1774708458783973 0.8591385633435515 1.0 1.0 30 Q13586,P20020,P21796,P30536,O76024,P62942 6 +Regulation of response to osmotic stress 0.3920796201447234 0.1765069098552616 0.8598957206276512 1.0 1.0 5 O95202 1 +Negative regulation of establishment of protein localization to mitochondrion 0.5259084791386388 0.1758579909853721 0.8604055092651055 1.0 1.0 2 O95429 1 +Positive regulation of small molecule metabolic process 0.3087693906869696 0.1742208132768565 0.8616919290416414 1.0 1.0 15 P54646,Q92604,P16435,Q16531,P04083,P00403,P05067,O75746 8 +Negative regulation of calcineurin mediated signaling 0.5245625841184468 0.1731369458703348 0.8625437848547688 1.0 1.0 2 P42345 1 +Negative regulation of calcium mediated signaling 0.5245625841184468 0.1731369458703348 0.8625437848547688 1.0 1.0 2 P42345 1 +Glycolytic process through fructose 6 phosphate 0.3500025635838799 0.1708963922130056 0.8643052335291721 1.0 1.0 9 Q9BRR6 1 +Regulation of lymphocyte apoptotic process 0.3896934994947779 0.168959180984604 0.8658287485775615 1.0 1.0 5 P04637,P14174,Q96GD4,Q9HCL2 4 +Lateral ventricle development 0.522207267833121 0.1684372325631858 0.8662393191643458 1.0 1.0 2 Q9Y5K5 1 +Plasma membrane phospholipid scrambling 0.5202107724618803 0.1674959649546685 0.8669798221820011 1.0 1.0 3 Q4KMQ2 1 +Regulation of alternative mrna splicing via spliceosome 0.2780170150415302 0.1665335849450349 0.8677370552087982 1.0 1.0 26 P51114,P38159,P09651,P52756,Q07666,Q9UHX1,P62995 7 +Ether metabolic process 0.361287549739531 0.1657963497007734 0.8683172188826813 1.0 1.0 8 P49327,P07099 2 +Positive regulation of protein glycosylation 0.5208613728129325 0.1657872082245863 0.8683244131684755 1.0 1.0 2 Q9UHD1 1 +G quadruplex dna unwinding 0.5193652337806994 0.1656904746335247 0.8684005425804477 1.0 1.0 3 P22626 1 +Release of sequestered calcium ion into cytosol by endoplasmic reticulum 0.3883462445267751 0.1647404577848548 0.8691482713132508 1.0 1.0 5 P78417,P17612,P0DP25,Q9NVV0 4 +Establishment of endothelial intestinal barrier 0.3608228253174543 0.163959733061769 0.8697628431138886 1.0 1.0 8 P62820,P49327 2 +Synaptic vesicle uncoating 0.5198519515477897 0.163816656850417 0.8698754785541678 1.0 1.0 2 Q99961 1 +Positive regulation of synaptic vesicle recycling 0.5185060565275962 0.1612118863446435 0.8719265196207808 1.0 1.0 2 Q9Y263 1 +Regulation of peptidyl lysine acetylation 0.2854906289064755 0.1605961006048877 0.8724115262999683 1.0 1.0 19 Q969T9,Q01105,Q03164,Q14012,O75844 5 +Protein deneddylation 0.3594992289601265 0.1587507644426366 0.8738652410387693 1.0 1.0 8 Q9BT78,Q9UNS2 2 +Fibroblast migration 0.3100094706686332 0.1583207990781004 0.8742040195384826 1.0 1.0 14 O95470 1 +Cellular response to starvation 0.2723632103407233 0.1581714379696544 0.8743217096092208 1.0 1.0 30 P21964,P49327,Q9Y4P3,P04062 4 +Positive regulation of ossification 0.4166121344407861 0.1553592334061413 0.8765381209142502 1.0 1.0 4 Q4KMQ2 1 +Oocyte differentiation 0.3462336557168685 0.1550538292060962 0.8767788808344374 1.0 1.0 9 Q8N2A8,Q9Y2W6,Q12768 3 +Fibroblast proliferation 0.3093483969233337 0.1547531743551321 0.8770159078272857 1.0 1.0 14 P50402,O75844,Q71SY5 3 +Centriole elongation 0.5134589502018891 0.1516744434640971 0.8794437150919745 1.0 1.0 2 O43633 1 +Positive regulation of centriole replication 0.5134589502018847 0.1516744434640889 0.8794437150919809 1.0 1.0 2 P37198 1 +Regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion 0.414814814814811 0.1506854956255 0.8802238153946671 1.0 1.0 4 P78417,P0DP25,Q9NVV0 3 +Calcium mediated signaling using intracellular calcium source 0.512003681229105 0.1503588279548081 0.8804815224612317 1.0 1.0 3 P51572 1 +Positive regulation of peptidyl lysine acetylation 0.3595243264552588 0.1499650993656336 0.8807921504893703 1.0 1.0 7 Q969T9,Q9NRA0 2 +Phosphatidylserine acyl chain remodeling 0.5100942126514176 0.1455182744934877 0.8843016883599788 1.0 1.0 2 Q6P1A2 1 +Tumor necrosis factor superfamily cytokine production 0.2829368301716933 0.1437903103700715 0.8856660545643189 1.0 1.0 19 P14174,P30536,P10909,Q9Y385,Q9NRA0,P05067,Q08722 7 +Extracellular vesicle biogenesis 0.3162335470806577 0.1382122235365633 0.8900726948285147 1.0 1.0 11 O14964,Q9Y3E7,Q9UN37,O75351,Q92905,O43633,Q99816,P51149,Q92783,O00560 10 +Actin myosin filament sliding 0.5057200538358093 0.1377567042998531 0.8904327030003072 1.0 1.0 2 P60660 1 +Regulation of atpase coupled calcium transmembrane transporter activity 0.505383580080767 0.1371709498016645 0.8908956725285453 1.0 1.0 2 Q96GC9 1 +Positive regulation of atpase coupled calcium transmembrane transporter activity 0.505383580080767 0.1371709498016645 0.8908956725285453 1.0 1.0 2 Q96GC9 1 +Anaphase promoting complex dependent catabolic process 0.315901129296362 0.1366568614018528 0.8913020291542637 1.0 1.0 11 Q9UJX3,P53350,Q9UJX4,Q13042 4 +Positive regulation of ryanodine sensitive calcium release channel activity 0.5050471063257197 0.1365868062242787 0.8913574058619804 1.0 1.0 2 P0DP25 1 +Positive regulation of leukocyte proliferation 0.3129299909333916 0.1355264012580655 0.8921956916342715 1.0 1.0 12 P04083,Q9NPF0,P14174,P04439 4 +Intermediate filament bundle assembly 0.5043204979049603 0.1351046012632767 0.892529172254473 1.0 1.0 3 P07197 1 +Digestive system process 0.3281128673860172 0.1322095840256714 0.8948185207113779 1.0 1.0 10 Q16739 1 +Positive regulation of cyclic nucleotide phosphodiesterase activity 0.5016823687752487 0.1308338713246686 0.8959067278469481 1.0 1.0 2 P0DP25 1 +Positive regulation of golgi to plasma membrane protein transport 0.5016823687752436 0.1308338713246601 0.8959067278469548 1.0 1.0 2 O95573 1 +Negative regulation of rig i signaling pathway 0.4055295030693467 0.127366600695068 0.8986502496967761 1.0 1.0 4 Q86UT6 1 +Regulation of systemic arterial blood pressure 0.3546173999521921 0.1271138732729791 0.8988502712507616 1.0 1.0 6 P42892,P42785 2 +Intraciliary transport 0.3543927233139501 0.1263644738779442 0.8994434224229801 1.0 1.0 6 O43805,A0AVF1,Q15154 3 +Positive regulation of epithelial cell migration 0.2733078199212433 0.1250506199812489 0.9004834758739955 1.0 1.0 25 P09601,Q9NQC3,Q8WTV0 3 +Cellular response to extracellular stimulus 0.2678581950552726 0.1220276516851235 0.9028771190375796 1.0 1.0 41 P04062,O95831,Q9Y4P3,P09601,P49327,Q9Y371,P13473,Q9H773,P21964 9 +Box c d snornp assembly 0.4962987886944955 0.1219628429528349 0.902928445557639 1.0 1.0 2 Q9Y230 1 +Regulation of stem cell differentiation 0.2990668800880668 0.120312759932734 0.9042353965713072 1.0 1.0 15 Q9NX40,Q96J02,Q9Y6C9 3 +Folic acid containing compound catabolic process 0.4946164199192536 0.1192745089855923 0.9050578781950328 1.0 1.0 2 Q9NRN7 1 +Fibroblast activation 0.4020202020202013 0.1189191643743578 0.9053393985259286 1.0 1.0 4 Q6PHR2,Q15418,Q02952 3 +Regulation of nuclear transcribed mrna catabolic process nonsense mediated decay 0.4016835016834951 0.1181193416999223 0.9059730982751216 1.0 1.0 4 P11940,Q9Y5S9,Q99729 3 +Cellular response to gamma radiation 0.348817443035759 0.1179426909970201 0.9061130667668962 1.0 1.0 8 P12956,O75844 2 +Heterotypic cell cell adhesion 0.3487982739499168 0.1178714866302724 0.9061694860925706 1.0 1.0 8 Q08722,O75955 2 +Myoblast fusion 0.3502471781498791 0.1167287651022594 0.907074994838099 1.0 1.0 7 Q16539,O75955 2 +Actin mediated cell contraction 0.3057919721467229 0.1162905567755925 0.907422269436855 1.0 1.0 13 P05023,Q9UM22 2 +Animal organ regeneration 0.3020270270270302 0.1160418186386046 0.907619399166403 1.0 1.0 14 P50416,P19784,Q16611,O14744,Q8TCS8,P09601,P31939,P04818,P12429,O14965,P06493,P12004,P11717 13 +Cellular response to chemical stress 0.250543453119266 0.1149604245088957 0.9084764906771676 1.0 1.0 76 O95202,P04062,Q8N0U8,O95831,P30536,P16615,P09601,Q6NUK1,P49327,Q99720,Q9NR28,P00374,O75569,P33527 14 +Regulation of endoplasmic reticulum stress induced intrinsic apoptotic signaling pathway 0.3479042814082491 0.1145590157444878 0.9087946664627083 1.0 1.0 8 O60313,O76024 2 +Positive regulation of mitochondrial fission 0.3476062036412681 0.1134581850636543 0.90966731244517 1.0 1.0 8 Q9NX47,O00429,Q96QK1,Q8NE86,P11233,Q9Y3D6,Q96HS1 7 +Positive regulation of chemotaxis 0.2933549067044377 0.112071077242637 0.9107670499422986 1.0 1.0 16 Q12846,Q8NHP6,Q07021,Q4KMQ2 4 +Retina homeostasis 0.4917491142039087 0.1118067763089495 0.9109766144987196 1.0 1.0 3 P51790 1 +Mononuclear cell differentiation 0.2670828857447318 0.1110280861040346 0.911594074927902 1.0 1.0 38 P24390,P55327,P04062,O96005,P12956,P49327,P04083,P05141 8 +Myoblast differentiation 0.3482399456758027 0.1097617998721319 0.9125982872241434 1.0 1.0 7 Q14254,Q16539 2 +Fc receptor signaling pathway 0.3980261868468957 0.1095525003229673 0.9127642830720948 1.0 1.0 4 Q08722 1 +Diacylglycerol metabolic process 0.3979797979797934 0.1094452670689051 0.912849331433334 1.0 1.0 4 P52429,Q8NCC3,Q86UL3 3 +Nucleoside phosphate catabolic process 0.2774610724330566 0.1085105107903652 0.9135907433411832 1.0 1.0 19 Q9BW91,Q9H773 2 +Ventricular cardiac muscle cell differentiation 0.4865410497981223 0.1069219867007521 0.9148508703139588 1.0 1.0 2 P02545 1 +Ventricular cardiac muscle cell development 0.4865410497981223 0.1069219867007521 0.9148508703139588 1.0 1.0 2 P02545 1 +Transcription elongation from rna polymerase i promoter 0.3966329966329885 0.1063476196532523 0.9153065507613856 1.0 1.0 4 Q9GZS1,O15160,P18074 3 +Membrane protein ectodomain proteolysis 0.3341536132879478 0.1062657005687294 0.9153715444443532 1.0 1.0 9 Q9NZ08 1 +Lung alveolus development 0.4877145742174288 0.1047687145276395 0.9165593355818328 1.0 1.0 3 Q16706,Q9NVV0 2 +Pointed end actin filament capping 0.4841857335127919 0.103489780466641 0.9175742599504038 1.0 1.0 2 P28289 1 +Negative regulation of neural precursor cell proliferation 0.3946127946127913 0.1017579654161817 0.918948791132764 1.0 1.0 4 Q06481,P04637,Q13418 3 +Negative regulation of canonical wnt signaling pathway 0.3017062537527443 0.0962437994091708 0.9233269453505396 1.0 1.0 13 P50402,Q16539 2 +Chromosome organization involved in meiotic cell cycle 0.290226761626188 0.0947296159822773 0.9245295935984988 1.0 1.0 16 Q9BXW9,P30153,Q9BTX1,Q92791,P46379,O60566 6 +Positive regulation of cytokine production 0.2513520167423353 0.0929043176181627 0.9259795756223096 1.0 1.0 57 P14174,Q16539,Q99584,P62820,Q9UJZ1,P09601,P10909,Q9NUQ9,P41440,Q9NRA0,P04083,Q9NUD5,P35232,P49755,P05067,P04439,O75955 17 +Sterol transport 0.2676553322539783 0.0923256430417199 0.9264393151760688 1.0 1.0 27 P35610,O15118,P30536,P10909,Q86Y82,Q14849,Q8WTV0 7 +Negative regulation of reactive oxygen species metabolic process 0.3416439828302711 0.0918260457920405 0.9268362499340772 1.0 1.0 8 P52789 1 +Positive regulation of hydrolase activity 0.2564385322513658 0.0908951532815619 0.927575901372894 1.0 1.0 86 Q96A26,Q99538,P49354,O43464,Q8IZ81,Q9NZJ7,P18085,O95831,Q96HY6,P07602,P40616,O14737,P35232,P51572,Q9P0J0,P49327,P05067,O75915,Q9BXK5,Q92542,Q9NR28,Q99623 22 +Negative regulation of leukocyte apoptotic process 0.3895622895622844 0.0905835098006704 0.9278235353296944 1.0 1.0 4 P14174,Q96GD4,Q9HCL2 3 +Negative regulation of lymphocyte apoptotic process 0.3895622895622844 0.0905835098006704 0.9278235353296944 1.0 1.0 4 P14174,Q96GD4,Q9HCL2 3 +Cleavage furrow formation 0.4744279946164216 0.0900785384661451 0.9282248036992438 1.0 1.0 2 Q96GD4 1 +Reproductive system development 0.2562953130940738 0.0900195294219231 0.9282716955994484 1.0 1.0 53 Q15363,Q16539,O95470,Q9NZJ7,P35613,P07602,P49321,Q13043,Q15392 9 +Formation of extrachromosomal circular dna 0.4727456258411966 0.0878961216640509 0.929959239139114 1.0 1.0 2 Q9UQ84 1 +Response to uv c 0.4720726783310979 0.0870337160710112 0.930644712231816 1.0 1.0 2 Q16611 1 +Regulation of establishment or maintenance of cell polarity 0.3868500487139934 0.0847600696219236 0.9324521390807066 1.0 1.0 4 Q9NUQ9 1 +Protein localization to microtubule end 0.4680349932705308 0.0819850881222955 0.9346585714876544 1.0 1.0 2 Q15691 1 +Regulation of exosomal secretion 0.3161268556005349 0.0819624338461121 0.9346765863558296 1.0 1.0 10 O14964,Q9Y3E7,Q9UN37,O75351,O43633,Q99816,P51149,Q92783,O00560 9 +Macromolecule deacylation 0.2628578048706906 0.0790508337365273 0.9369921900609164 1.0 1.0 34 P49354,Q9UMR5,P50897 3 +Positive regulation of tor signaling 0.3388432696019698 0.0782531063896797 0.9376267187004196 1.0 1.0 7 Q9Y4R8,Q96EE3,Q15382,Q9H4A6 4 +Positive regulation of smooth muscle cell migration 0.4712218108380814 0.0782111788155914 0.9376600698491512 1.0 1.0 3 Q96N67,P31949 2 +Osteoclast differentiation 0.3266692916613321 0.0776583236396808 0.9380998468583406 1.0 1.0 9 Q15904,Q16539 2 +Negative regulation of mrna 3 end processing 0.3386118598382797 0.0762631293468632 0.9392097589035092 1.0 1.0 6 P18615,Q6PD62,O75150,Q5VTR2,Q6PJT7 5 +Positive regulation of carbohydrate metabolic process 0.3375694221763503 0.074125406665728 0.9409105992727428 1.0 1.0 7 P05067,P54646,O75746,Q16531 4 +Protein targeting to lysosome 0.299707979870056 0.0735912658306373 0.9413356211523076 1.0 1.0 12 Q14108,P13473 2 +Positive regulation of muscle cell differentiation 0.3376796846491505 0.0734644803113418 0.9414365082762322 1.0 1.0 6 Q16539 1 +Iron sulfur cluster assembly 0.3252581520451592 0.0724106204504019 0.9422751330861294 1.0 1.0 9 O75027,P38646 2 +Regulation of dna helicase activity 0.467182766745195 0.0722457256526624 0.9424063564114308 1.0 1.0 3 Q04837,P33993 2 +Regulation of anaphase promoting complex dependent catabolic process 0.466846179737448 0.0717580813008068 0.942794433054354 1.0 1.0 3 Q12834,P53350 2 +Regulation of skeletal muscle tissue development 0.3802866652533673 0.0711837455253302 0.9432515177886563 1.0 1.0 4 O75955 1 +Membrane invagination 0.2930895057641207 0.0709047600004298 0.9434735549807074 1.0 1.0 14 Q06481,Q13636,Q4KMQ2,P51790 4 +Cell fate specification 0.3794612794612764 0.069528245689902 0.944569150240729 1.0 1.0 4 Q9UJX6,Q14318,P05556 3 +Cellular response to xenobiotic stimulus 0.2652823128290865 0.0683036504322814 0.9455439182930688 1.0 1.0 20 O43169,P27544,P07099 3 +Negative regulation of tyrosine phosphorylation of stat protein 0.4559219380888314 0.0681056812353045 0.9457015078883222 1.0 1.0 2 P30153 1 +Anoikis 0.3357176403996083 0.067634166063628 0.9460768570737654 1.0 1.0 6 Q9Y3E5,P05556,Q07820 3 +T cell activation 0.2587018831959933 0.0664366249955564 0.9470302120710196 1.0 1.0 48 P24390,P04062,Q9UJZ1,O96005,Q92542,Q9NUQ9,P04083,P62942,Q96J02,Q08722 10 +Response to l glutamate 0.3775541425488625 0.0657473791268238 0.947578950900184 1.0 1.0 4 O95831 1 +Cell cell adhesion via plasma membrane adhesion molecules 0.3341335444231433 0.0656573841288832 0.9476506017013512 1.0 1.0 8 P35613 1 +Positive regulation of leukocyte chemotaxis 0.2996286861744901 0.0640540985155424 0.9489271508238386 1.0 1.0 11 Q07021,Q8NHP6,Q4KMQ2 3 +Regulation of leukocyte proliferation 0.2643540770024182 0.0623853639668759 0.9502559501184618 1.0 1.0 20 Q9NPF0,P14174,P04439,P04083,Q96J02,P22466 6 +Mitochondrion localization 0.2799540512395448 0.0623280909655213 0.9503015586045952 1.0 1.0 17 P07196,O60313,Q6PJG6,O95140,Q9UH62,Q9UBK9,O75153,Q8IWA4 8 +Regulation of peptidyl tyrosine phosphorylation 0.2647310004886792 0.0621900855273042 0.9504114578111058 1.0 1.0 25 P14174,P30153,Q9UNH7,Q9H223,P18031,O95684,Q13432,P42345,P05067 9 +Regulation of myeloid cell apoptotic process 0.351482019329306 0.0620883140414448 0.9504925030879684 1.0 1.0 5 P14174 1 +Regulation of animal organ morphogenesis 0.3335697666104326 0.0613939259451785 0.9510454896301006 1.0 1.0 7 Q8TAA9 1 +Negative regulation of fibroblast proliferation 0.3334135221996137 0.0608924451179102 0.9514448662048856 1.0 1.0 6 P50402 1 +Negative regulation of transmembrane transport 0.2640691020774415 0.060575753886842 0.9516970836498986 1.0 1.0 20 Q06481,P21796,Q9HD26,Q8N668,P62942,Q9P2B4,O75915 7 +Calcium ion regulated exocytosis 0.321875613867163 0.0600256607938674 0.9521351971769608 1.0 1.0 9 P16615 1 +Regulation of systemic arterial blood pressure mediated by a chemical signal 0.3733798400116331 0.0576879279429749 0.9539972097883926 1.0 1.0 4 P42892 1 +Negative regulation of receptor signaling pathway via jak stat 0.4560753954897314 0.0569160060690462 0.954612103982084 1.0 1.0 3 O14964,P30153 2 +Negative regulation of receptor signaling pathway via stat 0.4560753954897314 0.0569160060690462 0.954612103982084 1.0 1.0 3 O14964,P30153 2 +Arf protein signal transduction 0.455402221474251 0.0560370610133806 0.9553122831131328 1.0 1.0 3 Q8N6T3,Q15555 2 +Limbic system development 0.2635208661020013 0.0542118411825612 0.9567663866595412 1.0 1.0 21 O14949,O75569 2 +Negative regulation of dna biosynthetic process 0.3090418353576235 0.0539574004189441 0.9569691043096172 1.0 1.0 10 Q96BK5,P04637,Q9H0A0,P27544,Q00839,Q9NVN8,P09651,Q01780,P07910 9 +Protein transport along microtubule 0.4390982503364745 0.0518261022761209 0.9586672568866108 1.0 1.0 2 P04792 1 +Axo dendritic protein transport 0.4390982503364745 0.0518261022761209 0.9586672568866108 1.0 1.0 2 P04792 1 +Protein localization to presynapse 0.4390982503364745 0.0518261022761209 0.9586672568866108 1.0 1.0 2 P04792 1 +Leukocyte proliferation 0.2588960460212562 0.0486551515518284 0.9611941173917355 1.0 1.0 33 P14174,P22466,P04062,Q92542,P04439,P10909,P02786,P04083,Q96J02,Q9NPF0 10 +Regulation of proton transport 0.3185568803019135 0.0481447913934457 0.9616008492027696 1.0 1.0 9 Q8TAD4,Q9NRA0,Q99623 3 +Positive regulation of transporter activity 0.2674370598012709 0.0468309347022044 0.9626479737469182 1.0 1.0 19 P08183,Q13586,O75323,Q96GC9,Q03164,O00483,P22466 7 +Oligodendrocyte development 0.3284518092547187 0.0466921363951977 0.9627585977594024 1.0 1.0 8 Q92542 1 +Production of molecular mediator involved in inflammatory response 0.2933173920909386 0.0454514884695508 0.963747441498474 1.0 1.0 12 Q06481,Q16539,Q9UNH7,P51809,O95219,Q8IV08,Q9BWS9 7 +Negative regulation of cell growth involved in cardiac muscle cell development 0.4300134589502097 0.0443859323383339 0.9645967749656896 1.0 1.0 2 O94826 1 +Regulation of cell growth involved in cardiac muscle cell development 0.4300134589502097 0.0443859323383339 0.9645967749656896 1.0 1.0 2 O94826 1 +Negative regulation of cardiac muscle tissue growth 0.4300134589502097 0.0443859323383339 0.9645967749656896 1.0 1.0 2 O94826 1 +Cellular modified amino acid metabolic process 0.2529960177495464 0.0435511447001835 0.965262195597094 1.0 1.0 52 Q99735,P23786,Q8NCC3,P16435,Q9H2D1,Q9H7Z7,O60725,Q8N2K0,Q9UHG3,P07858,P00374 11 +Dendritic cell chemotaxis 0.3654387115442313 0.0431737637822187 0.9655630190507714 1.0 1.0 4 Q4KMQ2 1 +Neural tube formation 0.2838085274862038 0.0413405753516752 0.9670243862508604 1.0 1.0 15 Q15363,O60313 2 +Negative regulation of telomere maintenance via telomerase 0.3269295584765792 0.0410377444732718 0.9672658054559666 1.0 1.0 7 Q96BK5,Q9H0A0,Q00839,Q9NVN8,P09651,P07910 6 +Negative regulation of receptor mediated endocytosis 0.3053466765131538 0.0398798716808427 0.968188898407216 1.0 1.0 10 Q13432,P05067,Q9UHD9 3 +Astrocyte development 0.3419537671044578 0.0397921524076034 0.9682588327492976 1.0 1.0 5 P08670 1 +Positive regulation of exosomal secretion 0.316020236087689 0.0392476927250871 0.9686929096103196 1.0 1.0 9 O14964,Q9UN37,O75351,O43633,Q99816,P51149,Q92783,O00560 8 +Negative regulation of toll like receptor signaling pathway 0.4229475100942128 0.0392079398335466 0.9687246034337718 1.0 1.0 2 Q6SZW1 1 +Negative regulation of calcium ion dependent exocytosis 0.4216016150740248 0.0382794705271166 0.9694648589340368 1.0 1.0 2 P04899 1 +Regulation of striated muscle contraction 0.293216754748154 0.0374789171393096 0.9701031500202736 1.0 1.0 11 P05023 1 +Positive regulation of inclusion body assembly 0.3616161616161605 0.0365682844544566 0.97082923194712 1.0 1.0 4 P49427,P62195,P10909 3 +Granulocyte activation 0.325356854130153 0.036361676453641 0.9709939717175908 1.0 1.0 7 Q12846,P04083 2 +Negative regulation of endocytosis 0.2924609271072947 0.0344266925659125 0.9725368984942668 1.0 1.0 11 Q13432,P05067,Q9UHD9 3 +Dorsal ventral neural tube patterning 0.414535666218043 0.0336961454683541 0.9731194526994198 1.0 1.0 2 Q14318 1 +Columnar cuboidal epithelial cell maturation 0.4141991924629873 0.0334897936105654 0.973284004786856 1.0 1.0 2 Q86UL3 1 +Meiotic cytokinesis 0.4362167620329769 0.0333275224309628 0.9734134062204716 1.0 1.0 3 Q12768,P61158 2 +Feeding behavior 0.3239046153915971 0.0320465038233024 0.9744349652363348 1.0 1.0 8 Q9GZP9,P05067,P22466 3 +Diterpenoid biosynthetic process 0.4074697173620444 0.0295806512934906 0.9764014965917468 1.0 1.0 2 P09455 1 +Response to thyroxine 0.4017496635262569 0.0265714218425682 0.978801567274444 1.0 1.0 2 O94826 1 +Response to l phenylalanine derivative 0.4017496635262569 0.0265714218425682 0.978801567274444 1.0 1.0 2 O94826 1 +Regulation of hepatic stellate cell activation 0.4017496635262473 0.0265714218425635 0.9788015672744476 1.0 1.0 2 Q15418 1 +Regulation of epithelial cell migration 0.2569329801054256 0.0259398953574151 0.979305278849186 1.0 1.0 35 Q16539,P09601,P57105,Q9NQC3,Q8WTV0 5 +Glycerol 3 phosphate metabolic process 0.3977119784656751 0.0246115524323403 0.9803648045831416 1.0 1.0 2 P43304 1 +Natural killer cell degranulation 0.4264172901053118 0.0234120011411137 0.981321632104356 1.0 1.0 3 P11279 1 +Natural killer cell activation involved in immune response 0.4264172901053118 0.0234120011411137 0.981321632104356 1.0 1.0 3 P11279 1 +Regulation of cysteine type endopeptidase activity involved in execution phase of apoptosis 0.3946837146702612 0.0232269984039236 0.9814692028019965 1.0 1.0 2 Q13177 1 +Segmentation 0.2875936307127184 0.0213131656643751 0.982995841543724 1.0 1.0 12 Q8N2A8 1 +Apoptotic cell clearance 0.3203962747658302 0.0210775224686213 0.9831838153833676 1.0 1.0 8 Q8WTV0 1 +Protein localization to plasma membrane 0.2375042747145175 0.0206959981512646 0.9834881613501788 1.0 1.0 69 Q15363,Q12846,O15400,Q9UNK0,Q15904,P35613,Q15436,Q4J6C6,Q9H4A6,Q8N2H4,P41440,P61026,O15258,Q9BXS4,O00264,O75955 16 +Protein targeting to vacuole 0.2719704773550849 0.0193999035363801 0.9845220873615584 1.0 1.0 17 Q96RL7,Q14108,Q5THJ4,P13473 4 +Neutrophil activation involved in immune response 0.4217435207000953 0.0190648711520972 0.9847893550934004 1.0 1.0 3 P51809,P12429 2 +Neutrophil degranulation 0.4217435207000953 0.0190648711520972 0.9847893550934004 1.0 1.0 3 P51809,P12429 2 +Regulation of core promoter binding 0.3792059219380862 0.0172016286108046 0.986275762938648 1.0 1.0 2 Q00403 1 +Positive regulation of cell migration by vascular endothelial growth factor signaling pathway 0.3778600269179001 0.0167544915506966 0.986632475276822 1.0 1.0 2 P04792 1 +Vascular endothelial growth factor signaling pathway 0.3778600269179001 0.0167544915506966 0.986632475276822 1.0 1.0 2 P04792 1 +Regulation of erbb signaling pathway 0.2989482579340689 0.0163920009551144 0.9869216612064532 1.0 1.0 10 Q9NQC3,Q9Y5X3 2 +Positive regulation of gliogenesis 0.3092748735244477 0.0163819715138467 0.9869296624684192 1.0 1.0 9 O14744,Q15382,O94874,Q9UMS4,Q13547,P30536,Q14118,P42345 8 +Cardiac conduction system development 0.376514131897718 0.0163187338785075 0.9869801120574128 1.0 1.0 2 Q14126 1 +Positive regulation of filopodium assembly 0.348148148148149 0.015246515051495 0.9878355123213292 1.0 1.0 4 P11233,Q06787,P60953 3 +Response to acetylcholine 0.3704576043068657 0.0144933318822402 0.988436399093234 1.0 1.0 2 P04899 1 +Negative regulation of lyase activity 0.3697846567967716 0.0143037066084367 0.9885876824886636 1.0 1.0 2 P04899 1 +Negative regulation of adenylate cyclase activity 0.3697846567967716 0.0143037066084367 0.9885876824886636 1.0 1.0 2 P04899 1 +Oocyte maturation 0.3471380471380472 0.0137684389144276 0.9890147222446036 1.0 1.0 4 Q12768,Q15645,P30153 3 +Neural tube patterning 0.4146751935375179 0.0129420197320837 0.9896740505299588 1.0 1.0 3 Q14318,O75787 2 +Positive regulation of i kappab phosphorylation 0.3617092866756396 0.0122203197068501 0.9902498382538064 1.0 1.0 2 Q96HY6 1 +Regulation of i kappab phosphorylation 0.3617092866756396 0.0122203197068501 0.9902498382538064 1.0 1.0 2 Q96HY6 1 +Positive regulation of maintenance of sister chromatid cohesion 0.359353970390308 0.0116759683603469 0.990684136782539 1.0 1.0 2 Q96MF7 1 +Regulation of maintenance of sister chromatid cohesion 0.359353970390308 0.0116759683603469 0.990684136782539 1.0 1.0 2 Q96MF7 1 +Myelin maintenance 0.3285016118684815 0.0113941209826692 0.9909090034923752 1.0 1.0 5 O15121 1 +Response to x ray 0.3077262485028456 0.0112980249362103 0.990985672109106 1.0 1.0 9 P12956,Q70UQ0 2 +Voluntary musculoskeletal movement 0.4119824974755907 0.0107485816869406 0.9914240377548031 1.0 1.0 3 P42345,P18887 2 +Regulation of protein dephosphorylation 0.2573806563293654 0.0103366533176308 0.991752690773638 1.0 1.0 24 Q86XL3,P04062 2 +Regulation of apoptotic signaling pathway 0.2506531422342059 0.0094627229368637 0.9924499521415032 1.0 1.0 87 Q12846,P14174,O60313,Q9P0J0,P09601,Q9H3K2,Q9NQX7,O76024,P49327,Q13043,P30154,P51572,P45880,O75569,Q8WUK0,P05141 16 +Positive regulation of anoikis 0.3425302826379481 0.0085110993734423 0.9932092072007316 1.0 1.0 2 Q9Y3E5 1 +Negative regulation of peptidyl serine phosphorylation 0.408616627398162 0.0081118190798037 0.9935277757767372 1.0 1.0 3 P63244,Q16611 2 +Cd4 positive alpha beta t cell activation 0.3267672432081953 0.0079960595682833 0.9936201355081452 1.0 1.0 5 Q9UJZ1 1 +Torc2 signaling 0.3320995962314961 0.0070900516294698 0.994343004664682 1.0 1.0 2 Q9Y4R8 1 +Response to calcium ion 0.2564600101349893 0.0069021288406789 0.9944929416868612 1.0 1.0 22 Q13586,Q9UJS0,Q14103,P54646,Q99538,Q92542,Q6NUK1,O75746 8 +Abscission 0.342087542087537 0.0066271486938465 0.994712339079948 1.0 1.0 4 P53990,Q96GD4,Q8N0X7 3 +Synapse maturation 0.3260357022566502 0.0065807876711918 0.9947493290175252 1.0 1.0 5 Q9UJX6,Q12834,P07737,P07196 4 +Regulation of mitochondrial dna replication 0.4064655825260597 0.0064867746485112 0.9948243389556934 1.0 1.0 3 Q9UJZ1 1 +Positive regulation of intracellular lipid transport 0.3203230148048382 0.0058776771899578 0.9953103191192356 1.0 1.0 2 P22307 1 +Regulation of intracellular lipid transport 0.3203230148048382 0.0058776771899578 0.9953103191192356 1.0 1.0 2 P22307 1 +Cellular response to external stimulus 0.2536855591928361 0.0058054833963739 0.9953679204497056 1.0 1.0 46 P04062,O95831,Q9Y4P3,P09601,P49327,Q9Y371,P13473,Q9H773,P21964 9 +Regulation of response to interferon gamma 0.2954239569313523 0.0043124412059105 0.996559180407343 1.0 1.0 2 Q16543 1 +Central nervous system maturation 0.2947510094212602 0.0042842568599531 0.9965816680540984 1.0 1.0 2 O75787 1 +Regulation of sodium ion transport 0.2813887606446125 0.0041221117415618 0.996711039997734 1.0 1.0 13 P05023 1 +Positive regulation of voltage gated calcium channel activity 0.2890309555854562 0.0040676771150046 0.9967544721816914 1.0 1.0 2 O75323 1 +Positive regulation of endothelial cell migration 0.2646873688876333 0.0036285888504822 0.9971048113320262 1.0 1.0 18 P09601,Q8WTV0 2 +Cysteine metabolic process 0.4018848872433473 0.0031787044978952 0.9974637650288638 1.0 1.0 3 P25325,Q16762 2 +Hepatic stellate cell activation 0.4018848872433458 0.003178704497894 0.9974637650288648 1.0 1.0 3 Q15418,Q02952 2 +I kappab phosphorylation 0.3390572390572392 0.0025397124484836 0.997973604826898 1.0 1.0 4 Q8IUD2,Q12933,Q96HY6 3 +Mitochondrial translational elongation 0.339019871941648 0.0024902247955334 0.9980130901362596 1.0 1.0 4 P49411,Q96RP9 2 +T helper 1 cell differentiation 0.3976307597007292 0.0002875504832723 0.9997705679121074 1.0 1.0 3 P04083 1 +T helper 1 type immune response 0.3976307597007292 0.0002875504832723 0.9997705679121074 1.0 1.0 3 P04083 1 +Regulation of collagen metabolic process 0.3975578622474901 0.0002394950675181 0.9998089105850656 1.0 1.0 3 P08670 1 +Generation of precursor metabolites and energy 0.3118843634921018 0.0001872643863455 0.99985058463822 1.0 1.0 178 P35610,P13073,Q9UJS0,P14406,Q9H3K2,P00403,O96000,Q13423,Q9UDW1,O75964,O95139,P00846,P04062,Q9Y6M9,O43676,O75438,O14949,Q15070,Q9NZ45,P24539,Q9P0J0,P21912,O43819,Q9BRR6,P52789,P03886,Q9BSK2,O15121,Q15067,P12235,P22695 31 +Trophoblast cell migration 0.3973941473279219 0.0001317514937612 0.9998948775175692 1.0 1.0 3 Q7Z739 1 diff --git a/msigdb_gobp/selections.json b/msigdb_gobp/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..f7e09c6ee86a718c0adf5795580384f5d444f8c8 --- /dev/null +++ b/msigdb_gobp/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["10 formyltetrahydrofolate metabolic process", "2 oxoglutarate metabolic process", "2fe 2s cluster assembly", "3 phosphoadenosine 5 phosphosulfate biosynthetic process", "3 phosphoadenosine 5 phosphosulfate metabolic process", "3 utr mediated mrna destabilization", "3 utr mediated mrna stabilization", "5 phosphoribose 1 diphosphate metabolic process", "5s class rrna transcription by rna polymerase iii", "Abscission", "Acetyl coa biosynthetic process", "Acetyl coa biosynthetic process from pyruvate", "Acetyl coa metabolic process", "Acid secretion", "Acidic amino acid transport", "Acrosome assembly", "Actin crosslink formation", "Actin cytoskeleton reorganization", "Actin filament based movement", "Actin filament based process", "Actin filament based transport", "Actin filament bundle organization", "Actin filament depolymerization", "Actin filament network formation", "Actin filament organization", "Actin filament polymerization", "Actin filament reorganization", "Actin filament severing", "Actin mediated cell contraction", "Actin modification", "Actin myosin filament sliding", "Actin nucleation", "Actin polymerization dependent cell motility", "Actin polymerization or depolymerization", "Action potential", "Activated t cell proliferation", "Activation induced cell death of t cells", "Activation of adenylate cyclase activity", "Activation of cysteine type endopeptidase activity", "Activation of cysteine type endopeptidase activity involved in apoptotic process", "Activation of cysteine type endopeptidase activity involved in apoptotic process by cytochrome c", "Activation of gtpase activity", "Activation of immune response", "Activation of innate immune response", "Activation of janus kinase activity", "Activation of nf kappab inducing kinase activity", "Activation of phospholipase c activity", "Activation of phospholipase d activity", "Activation of protein kinase activity", "Activation of protein kinase b activity", "Activation of protein kinase c activity", "Activation of store operated calcium channel activity", "Activin receptor signaling pathway", "Actomyosin contractile ring organization", "Actomyosin structure organization", "Acute inflammatory response", "Acute inflammatory response to antigenic stimulus", "Acute phase response", "Acyl carnitine transmembrane transport", "Acylglycerol homeostasis", "Acylglycerol transport", "Adaptation of signaling pathway", "Adaptive immune response", "Adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains", "Adaptive thermogenesis", "Adenosine metabolic process", "Adenosine to inosine editing", "Adenylate cyclase activating adrenergic receptor signaling pathway", "Adenylate cyclase activating adrenergic receptor signaling pathway involved in heart process", "Adenylate cyclase activating dopamine receptor signaling pathway", "Adenylate cyclase activating g protein coupled receptor signaling pathway", "Adenylate cyclase inhibiting dopamine receptor signaling pathway", "Adenylate cyclase inhibiting g protein coupled receptor signaling pathway", "Adenylate cyclase modulating g protein coupled receptor signaling pathway", "Adherens junction assembly", "Adherens junction maintenance", "Adherens junction organization", "Adhesion of symbiont to host", "Adhesion of symbiont to host cell", "Adiponectin activated signaling pathway", "Adipose tissue development", "Adp biosynthetic process", "Adp metabolic process", "Adp transport", "Adrenal gland development", "Adrenergic receptor signaling pathway", "Adult behavior", "Adult locomotory behavior", "Aerobic respiration", "Aggrephagy", "Aggresome assembly", "Aging", "Alanine catabolic process", "Alanine transport", "Alcohol biosynthetic process", "Alcohol catabolic process", "Alcohol metabolic process", "Aldehyde biosynthetic process", "Aldehyde catabolic process", "Alditol biosynthetic process", "Alditol catabolic process", "Alditol metabolic process", "Alditol phosphate metabolic process", "Alkanesulfonate metabolic process", "Allantoin metabolic process", "Alpha amino acid catabolic process", "Alpha amino acid metabolic process", "Alpha beta t cell activation", "Alpha beta t cell differentiation", "Alpha beta t cell proliferation", "Alpha ketoglutarate transport", "Alpha linolenic acid metabolic process", "Alternative mrna splicing via spliceosome", "Ameboidal type cell migration", "Amelogenesis", "Amide biosynthetic process", "Amide transport", "Amine biosynthetic process", "Amine catabolic process", "Amine metabolic process", "Amine transport", "Amino acid activation", "Amino acid betaine biosynthetic process", "Amino acid betaine metabolic process", "Amino acid betaine transport", "Amino acid homeostasis", "Amino acid import", "Amino acid import across plasma membrane", "Amino acid neurotransmitter reuptake", "Amino acid salvage", "Amino acid transmembrane transport", "Amino acid transport", "Amino sugar biosynthetic process", "Amino sugar catabolic process", "Amino sugar metabolic process", "Aminoacyl trna metabolism involved in translational fidelity", "Aminoglycan biosynthetic process", "Aminoglycan catabolic process", "Aminoglycan metabolic process", "Aminoglycoside antibiotic metabolic process", "Aminophospholipid translocation", "Aminophospholipid transport", "Ammonium ion metabolic process", "Amp biosynthetic process", "Amp metabolic process", "Amp salvage", "Amygdala development", "Amyloid beta clearance", "Amyloid beta clearance by cellular catabolic process", "Amyloid beta clearance by transcytosis", "Amyloid beta formation", "Amyloid beta metabolic process", "Amyloid fibril formation", "Amyloid precursor protein biosynthetic process", "Amyloid precursor protein catabolic process", "Amyloid precursor protein metabolic process", "Anagen", "Anaphase promoting complex dependent catabolic process", "Anatomical structure arrangement", "Anatomical structure formation involved in morphogenesis", "Anatomical structure homeostasis", "Anatomical structure maturation", "Androgen catabolic process", "Androgen metabolic process", "Androgen receptor signaling pathway", "Angiogenesis involved in wound healing", "Angiotensin activated signaling pathway", "Animal organ formation", "Animal organ morphogenesis", "Animal organ regeneration", "Anion homeostasis", "Anion transmembrane transport", "Anion transport", "Anoikis", "Anterior head development", "Anterior posterior axis specification", "Anterior posterior pattern specification", "Anterograde axonal transport", "Anterograde axonal transport of mitochondrion", "Anterograde dendritic transport", "Anterograde dendritic transport of neurotransmitter receptor complex", "Anterograde neuronal dense core vesicle transport", "Antibacterial humoral response", "Antigen processing and presentation", "Antigen processing and presentation of endogenous antigen", "Antigen processing and presentation of endogenous peptide antigen", "Antigen processing and presentation of endogenous peptide antigen via mhc class i via er pathway", "Antigen processing and presentation of exogenous antigen", "Antigen processing and presentation of exogenous peptide antigen", "Antigen processing and presentation of exogenous peptide antigen via mhc class i", "Antigen processing and presentation of exogenous peptide antigen via mhc class ii", "Antigen processing and presentation of lipid antigen via mhc class ib", "Antigen processing and presentation of peptide antigen", "Antigen processing and presentation of peptide antigen via mhc class i", "Antigen processing and presentation of peptide or polysaccharide antigen via mhc class ii", "Antigen processing and presentation via mhc class ib", "Antigen receptor mediated signaling pathway", "Antimicrobial humoral immune response mediated by antimicrobial peptide", "Antimicrobial humoral response", "Antiviral innate immune response", "Aorta development", "Aorta morphogenesis", "Aortic valve morphogenesis", "Apical junction assembly", "Apical protein localization", "Apoptotic cell clearance", "Apoptotic chromosome condensation", "Apoptotic dna fragmentation", "Apoptotic mitochondrial changes", "Apoptotic process involved in blood vessel morphogenesis", "Apoptotic process involved in development", "Apoptotic process involved in morphogenesis", "Apoptotic signaling pathway", "Appendage development", "Appendage morphogenesis", "Arachidonic acid metabolic process", "Arachidonic acid secretion", "Arf protein signal transduction", "Arginine catabolic process", "Arginine metabolic process", "Aromatic amino acid family catabolic process", "Aromatic amino acid family metabolic process", "Aromatic amino acid transport", "Arp2 3 complex mediated actin nucleation", "Artery development", "Artery morphogenesis", "Asparagine metabolic process", "Aspartate family amino acid biosynthetic process", "Aspartate family amino acid catabolic process", "Aspartate family amino acid metabolic process", "Aspartate metabolic process", "Aspartate transmembrane transport", "Associative learning", "Astral microtubule organization", "Astrocyte activation", "Astrocyte cell migration", "Astrocyte development", "Astrocyte differentiation", "Asymmetric cell division", "Asymmetric neuroblast division", "Atf6 mediated unfolded protein response", "Atp biosynthetic process", "Atp metabolic process", "Atp synthesis coupled electron transport", "Atp synthesis coupled proton transport", "Atp transport", "Atrial cardiac muscle cell membrane repolarization", "Atrial cardiac muscle cell to av node cell signaling", "Atrial septum development", "Atrial septum morphogenesis", "Atrioventricular canal development", "Attachment of gpi anchor to protein", "Attachment of mitotic spindle microtubules to kinetochore", "Attachment of spindle microtubules to kinetochore", "Auditory receptor cell development", "Auditory receptor cell morphogenesis", "Autonomic nervous system development", "Autophagic cell death", "Autophagosome maturation", "Autophagosome membrane docking", "Autophagosome organization", "Autophagy of mitochondrion", "Autophagy of nucleus", "Autophagy of peroxisome", "Axial mesoderm development", "Axis elongation", "Axis specification", "Axo dendritic protein transport", "Axo dendritic transport", "Axon choice point recognition", "Axon development", "Axon ensheathment in central nervous system", "Axon extension", "Axon midline choice point recognition", "Axonal fasciculation", "Axonal transport", "Axonal transport of mitochondrion", "Axonemal dynein complex assembly", "Axoneme assembly", "Axonogenesis involved in innervation", "Azole transmembrane transport", "B cell activation", "B cell activation involved in immune response", "B cell apoptotic process", "B cell differentiation", "B cell homeostasis", "B cell lineage commitment", "B cell mediated immunity", "B cell proliferation", "B cell receptor signaling pathway", "Barbed end actin filament capping", "Base conversion or substitution editing", "Base excision repair", "Base excision repair ap site formation", "Base excision repair gap filling", "Basement membrane assembly", "Basement membrane organization", "Behavior", "Behavioral response to cocaine", "Behavioral response to ethanol", "Behavioral response to pain", "Benzene containing compound metabolic process", "Bergmann glial cell differentiation", "Bicarbonate transport", "Bile acid and bile salt transport", "Bile acid biosynthetic process", "Bile acid metabolic process", "Bile acid secretion", "Binding of sperm to zona pellucida", "Biological adhesion", "Biological phase", "Biological process involved in interaction with host", "Biological process involved in interaction with symbiont", "Biological process involved in interspecies interaction between organisms", "Biological process involved in intraspecies interaction between organisms", "Biological process involved in symbiotic interaction", "Biomineralization", "Blastocyst development", "Blastocyst formation", "Blastocyst growth", "Blastoderm segmentation", "Bleb assembly", "Blood vessel endothelial cell migration", "Blood vessel endothelial cell proliferation involved in sprouting angiogenesis", "Blood vessel maturation", "Blood vessel morphogenesis", "Blood vessel remodeling", "Body fluid secretion", "Body morphogenesis", "Bone cell development", "Bone development", "Bone growth", "Bone marrow development", "Bone mineralization", "Bone morphogenesis", "Bone remodeling", "Bone resorption", "Box c d snornp assembly", "Bradykinin catabolic process", "Brain derived neurotrophic factor receptor signaling pathway", "Brain morphogenesis", "Brainstem development", "Branched chain amino acid biosynthetic process", "Branched chain amino acid catabolic process", "Branched chain amino acid metabolic process", "Branched chain amino acid transport", "Branching involved in blood vessel morphogenesis", "Branching involved in labyrinthine layer morphogenesis", "Branching involved in mammary gland duct morphogenesis", "Branching involved in salivary gland morphogenesis", "Branching morphogenesis of a nerve", "Branching morphogenesis of an epithelial tube", "Brown fat cell differentiation", "Bundle of his cell to purkinje myocyte communication", "C 5 methylation of cytosine", "C terminal protein amino acid modification", "C terminal protein lipidation", "C21 steroid hormone biosynthetic process", "C21 steroid hormone metabolic process", "C4 dicarboxylate transport", "Cadmium ion transmembrane transport", "Calcineurin mediated signaling", "Calcium activated phospholipid scrambling", "Calcium dependent cell cell adhesion via plasma membrane cell adhesion molecules", "Calcium import into the mitochondrion", "Calcium ion export", "Calcium ion export across plasma membrane", "Calcium ion import", "Calcium ion import into sarcoplasmic reticulum", "Calcium ion regulated exocytosis", "Calcium ion regulated exocytosis of neurotransmitter", "Calcium ion transmembrane transport", "Calcium ion transmembrane transport via high voltage gated calcium channel", "Calcium ion transport", "Calcium ion transport into cytosol", "Calcium mediated signaling", "Calcium mediated signaling using intracellular calcium source", "Calmodulin dependent kinase signaling pathway", "Camera type eye development", "Camera type eye morphogenesis", "Camera type eye photoreceptor cell differentiation", "Camp mediated signaling", "Cannabinoid signaling pathway", "Canonical wnt signaling pathway", "Canonical wnt signaling pathway involved in heart development", "Canonical wnt signaling pathway involved in osteoblast differentiation", "Canonical wnt signaling pathway involved in regulation of cell proliferation", "Cap dependent translational initiation", "Carbohydrate biosynthetic process", "Carbohydrate catabolic process", "Carbohydrate derivative biosynthetic process", "Carbohydrate derivative catabolic process", "Carbohydrate derivative metabolic process", "Carbohydrate derivative transport", "Carbohydrate homeostasis", "Carbohydrate mediated signaling", "Carbohydrate metabolic process", "Carbohydrate phosphorylation", "Carbohydrate transmembrane transport", "Carbohydrate transport", "Carboxylic acid transport", "Cardiac atrium development", "Cardiac atrium morphogenesis", "Cardiac cell development", "Cardiac chamber development", "Cardiac chamber morphogenesis", "Cardiac conduction", "Cardiac conduction system development", "Cardiac epithelial to mesenchymal transition", "Cardiac muscle cell action potential", "Cardiac muscle cell action potential involved in contraction", "Cardiac muscle cell cardiac muscle cell adhesion", "Cardiac muscle cell contraction", "Cardiac muscle cell differentiation", "Cardiac muscle cell membrane repolarization", "Cardiac muscle cell proliferation", "Cardiac muscle contraction", "Cardiac muscle tissue development", "Cardiac muscle tissue morphogenesis", "Cardiac neural crest cell development involved in outflow tract morphogenesis", "Cardiac neural crest cell differentiation involved in heart development", "Cardiac neural crest cell migration involved in outflow tract morphogenesis", "Cardiac septum development", "Cardiac septum morphogenesis", "Cardiac ventricle development", "Cardiac ventricle morphogenesis", "Cardioblast differentiation", "Cardioblast proliferation", "Cardiocyte differentiation", "Cardiolipin acyl chain remodeling", "Cardiolipin biosynthetic process", "Cardiolipin metabolic process", "Carnitine metabolic process", "Carnitine transport", "Cartilage development", "Cartilage development involved in endochondral bone morphogenesis", "Catechol containing compound biosynthetic process", "Catechol containing compound catabolic process", "Catechol containing compound metabolic process", "Catecholamine uptake", "Catecholamine uptake involved in synaptic transmission", "Cation transmembrane transport", "Cation transport", "Caveola assembly", "Caveolin mediated endocytosis", "Cd4 positive alpha beta t cell activation", "Cd4 positive alpha beta t cell differentiation", "Cd4 positive or cd8 positive alpha beta t cell lineage commitment", "Cd40 signaling pathway", "Cd8 positive alpha beta t cell activation", "Cd8 positive alpha beta t cell proliferation", "Cdc42 protein signal transduction", "Cdp choline pathway", "Cdp diacylglycerol metabolic process", "Cell activation", "Cell activation involved in immune response", "Cell adhesion mediated by integrin", "Cell adhesion molecule production", "Cell aggregation", "Cell aging", "Cell cell adhesion", "Cell cell adhesion mediated by cadherin", "Cell cell adhesion mediated by integrin", "Cell cell adhesion via plasma membrane adhesion molecules", "Cell cell junction assembly", "Cell cell junction maintenance", "Cell cell junction organization", "Cell cell recognition", "Cell cell signaling", "Cell cell signaling by wnt", "Cell cell signaling involved in cardiac conduction", "Cell chemotaxis", "Cell communication by electrical coupling", "Cell communication by electrical coupling involved in cardiac conduction", "Cell communication involved in cardiac conduction", "Cell cycle", "Cell cycle checkpoint signaling", "Cell cycle dna replication", "Cell cycle dna replication initiation", "Cell cycle g1 s phase transition", "Cell cycle g2 m phase transition", "Cell cycle phase transition", "Cell cycle process", "Cell death in response to hydrogen peroxide", "Cell death in response to oxidative stress", "Cell differentiation in hindbrain", "Cell differentiation in spinal cord", "Cell differentiation involved in embryonic placenta development", "Cell differentiation involved in kidney development", "Cell differentiation involved in metanephros development", "Cell differentiation involved in phenotypic switching", "Cell division", "Cell fate commitment", "Cell fate commitment involved in formation of primary germ layer", "Cell fate determination", "Cell fate specification", "Cell growth", "Cell junction assembly", "Cell junction disassembly", "Cell junction maintenance", "Cell junction organization", "Cell killing", "Cell matrix adhesion", "Cell maturation", "Cell migration", "Cell migration in hindbrain", "Cell migration involved in gastrulation", "Cell migration involved in heart development", "Cell migration involved in sprouting angiogenesis", "Cell morphogenesis", "Cell morphogenesis involved in differentiation", "Cell morphogenesis involved in neuron differentiation", "Cell motility involved in cerebral cortex radial glia guided migration", "Cell part morphogenesis", "Cell projection assembly", "Cell projection organization", "Cell proliferation in forebrain", "Cell proliferation in hindbrain", "Cell proliferation involved in heart morphogenesis", "Cell proliferation involved in kidney development", "Cell proliferation involved in metanephros development", "Cell recognition", "Cell redox homeostasis", "Cell substrate adhesion", "Cell substrate junction organization", "Cell surface receptor signaling pathway involved in cell cell signaling", "Cell surface receptor signaling pathway involved in heart development", "Cell volume homeostasis", "Cellular aldehyde metabolic process", "Cellular amide metabolic process", "Cellular amino acid biosynthetic process", "Cellular amino acid catabolic process", "Cellular amino acid metabolic process", "Cellular anion homeostasis", "Cellular carbohydrate biosynthetic process", "Cellular carbohydrate catabolic process", "Cellular carbohydrate metabolic process", "Cellular component assembly involved in morphogenesis", "Cellular component disassembly", "Cellular component disassembly involved in execution phase of apoptosis", "Cellular component maintenance", "Cellular component morphogenesis", "Cellular copper ion homeostasis", "Cellular defense response", "Cellular detoxification of aldehyde", "Cellular extravasation", "Cellular glucan metabolic process", "Cellular glucose homeostasis", "Cellular homeostasis", "Cellular hormone metabolic process", "Cellular hyperosmotic response", "Cellular hyperosmotic salinity response", "Cellular hypotonic response", "Cellular ion homeostasis", "Cellular iron ion homeostasis", "Cellular ketone metabolic process", "Cellular lipid catabolic process", "Cellular lipid metabolic process", "Cellular macromolecule biosynthetic process", "Cellular macromolecule localization", "Cellular metabolic compound salvage", "Cellular modified amino acid biosynthetic process", "Cellular modified amino acid catabolic process", "Cellular modified amino acid metabolic process", "Cellular monovalent inorganic anion homeostasis", "Cellular monovalent inorganic cation homeostasis", "Cellular nitrogen compound catabolic process", "Cellular oxidant detoxification", "Cellular pigmentation", "Cellular polysaccharide catabolic process", "Cellular potassium ion homeostasis", "Cellular process involved in reproduction in multicellular organism", "Cellular protein catabolic process", "Cellular respiration", "Cellular response to abiotic stimulus", "Cellular response to acid chemical", "Cellular response to acidic ph", "Cellular response to alcohol", "Cellular response to aldehyde", "Cellular response to alkaloid", "Cellular response to amyloid beta", "Cellular response to antibiotic", "Cellular response to arsenic containing substance", "Cellular response to atp", "Cellular response to biotic stimulus", "Cellular response to brain derived neurotrophic factor stimulus", "Cellular response to cadmium ion", "Cellular response to caffeine", "Cellular response to calcium ion", "Cellular response to camp", "Cellular response to carbohydrate stimulus", "Cellular response to chemical stress", "Cellular response to cholesterol", "Cellular response to cold", "Cellular response to copper ion", "Cellular response to corticosteroid stimulus", "Cellular response to dexamethasone stimulus", "Cellular response to dna damage stimulus", "Cellular response to dsrna", "Cellular response to electrical stimulus", "Cellular response to endogenous stimulus", "Cellular response to epinephrine stimulus", "Cellular response to estradiol stimulus", "Cellular response to estrogen stimulus", "Cellular response to ethanol", "Cellular response to ether", "Cellular response to exogenous dsrna", "Cellular response to external stimulus", "Cellular response to extracellular stimulus", "Cellular response to fatty acid", "Cellular response to fluid shear stress", "Cellular response to follicle stimulating hormone stimulus", "Cellular response to gamma radiation", "Cellular response to glucose starvation", "Cellular response to gonadotropin stimulus", "Cellular response to growth hormone stimulus", "Cellular response to heat", "Cellular response to heparin", "Cellular response to histamine", "Cellular response to hormone stimulus", "Cellular response to hydrogen peroxide", "Cellular response to hyperoxia", "Cellular response to increased oxygen levels", "Cellular response to indole 3 methanol", "Cellular response to inorganic substance", "Cellular response to insulin like growth factor stimulus", "Cellular response to insulin stimulus", "Cellular response to interferon alpha", "Cellular response to interferon beta", "Cellular response to interferon gamma", "Cellular response to interleukin 1", "Cellular response to ionizing radiation", "Cellular response to iron ion", "Cellular response to ketone", "Cellular response to leptin stimulus", "Cellular response to leucine", "Cellular response to leucine starvation", "Cellular response to light intensity", "Cellular response to light stimulus", "Cellular response to lipid", "Cellular response to lipoprotein particle stimulus", "Cellular response to lithium ion", "Cellular response to low density lipoprotein particle stimulus", "Cellular response to manganese ion", "Cellular response to mechanical stimulus", "Cellular response to mineralocorticoid stimulus", "Cellular response to molecule of bacterial origin", "Cellular response to muramyl dipeptide", "Cellular response to nitrogen compound", "Cellular response to nitrogen starvation", "Cellular response to nitrosative stress", "Cellular response to nutrient", "Cellular response to organic cyclic compound", "Cellular response to osmotic stress", "Cellular response to oxidised low density lipoprotein particle stimulus", "Cellular response to oxygen containing compound", "Cellular response to oxygen glucose deprivation", "Cellular response to oxygen levels", "Cellular response to oxygen radical", "Cellular response to parathyroid hormone stimulus", "Cellular response to peptide", "Cellular response to peptide hormone stimulus", "Cellular response to peptidoglycan", "Cellular response to ph", "Cellular response to prostaglandin e stimulus", "Cellular response to prostaglandin stimulus", "Cellular response to purine containing compound", "Cellular response to radiation", "Cellular response to reactive nitrogen species", "Cellular response to reactive oxygen species", "Cellular response to retinoic acid", "Cellular response to salt", "Cellular response to salt stress", "Cellular response to sodium arsenite", "Cellular response to starvation", "Cellular response to steroid hormone stimulus", "Cellular response to sterol", "Cellular response to sterol depletion", "Cellular response to stress", "Cellular response to testosterone stimulus", "Cellular response to thyroid hormone stimulus", "Cellular response to topologically incorrect protein", "Cellular response to toxic substance", "Cellular response to unfolded protein", "Cellular response to uv", "Cellular response to uv a", "Cellular response to uv c", "Cellular response to vascular endothelial growth factor stimulus", "Cellular response to virus", "Cellular response to vitamin", "Cellular response to vitamin d", "Cellular response to water stimulus", "Cellular response to x ray", "Cellular response to xenobiotic stimulus", "Cellular response to zinc ion", "Cellular senescence", "Cellular sodium ion homeostasis", "Cellular sphingolipid homeostasis", "Cellular transition metal ion homeostasis", "Cellular triglyceride homeostasis", "Cellular trivalent inorganic anion homeostasis", "Cenp a containing chromatin organization", "Central nervous system development", "Central nervous system maturation", "Central nervous system myelin formation", "Central nervous system myelin maintenance", "Central nervous system neuron axonogenesis", "Central nervous system neuron development", "Central nervous system neuron differentiation", "Central nervous system projection neuron axonogenesis", "Centriole assembly", "Centriole centriole cohesion", "Centriole elongation", "Centromere complex assembly", "Centromeric sister chromatid cohesion", "Centrosome duplication", "Centrosome separation", "Ceramide biosynthetic process", "Ceramide catabolic process", "Ceramide metabolic process", "Ceramide transport", "Cerebellar cortex development", "Cerebellar cortex formation", "Cerebellar cortex morphogenesis", "Cerebellar granular layer development", "Cerebellar granular layer formation", "Cerebellar granular layer morphogenesis", "Cerebellar purkinje cell layer development", "Cerebellar purkinje cell layer formation", "Cerebellar purkinje cell layer morphogenesis", "Cerebral cortex cell migration", "Cerebral cortex development", "Cerebral cortex neuron differentiation", "Cerebral cortex radially oriented cell migration", "Cerebral cortex regionalization", "Cerebral cortex tangential migration", "Cerebrospinal fluid circulation", "Cgmp mediated signaling", "Changes to dna methylation involved in embryo development", "Chaperone cofactor dependent protein refolding", "Chaperone mediated autophagy", "Chaperone mediated protein complex assembly", "Chaperone mediated protein folding", "Chemical homeostasis", "Chemical homeostasis within a tissue", "Chemical synaptic transmission postsynaptic", "Chemokine c c motif ligand 5 production", "Chemokine c x c motif ligand 12 signaling pathway", "Chemokine c x c motif ligand 2 production", "Chemokine production", "Chemosensory behavior", "Chloride transmembrane transport", "Chloride transport", "Cholesterol catabolic process", "Cholesterol efflux", "Cholesterol storage", "Choline metabolic process", "Chondrocyte development", "Chondrocyte development involved in endochondral bone morphogenesis", "Chondrocyte differentiation", "Chondrocyte differentiation involved in endochondral bone morphogenesis", "Chondrocyte proliferation", "Chondroitin sulfate biosynthetic process", "Chondroitin sulfate proteoglycan biosynthetic process", "Chondroitin sulfate proteoglycan metabolic process", "Chorion development", "Chromatin assembly or disassembly", "Chromatin disassembly", "Chromatin organization", "Chromatin remodeling", "Chromatin remodeling at centromere", "Chromosome attachment to the nuclear envelope", "Chromosome condensation", "Chromosome localization", "Chromosome localization to nuclear envelope involved in homologous chromosome segregation", "Chromosome movement towards spindle pole", "Chromosome organization", "Chromosome organization involved in meiotic cell cycle", "Chromosome segregation", "Chromosome separation", "Cilium movement", "Cilium or flagellum dependent cell motility", "Cilium organization", "Circadian regulation of gene expression", "Circadian rhythm", "Circulatory system development", "Circulatory system process", "Citrate metabolic process", "Citrulline biosynthetic process", "Citrulline metabolic process", "Clathrin coat assembly", "Clathrin dependent endocytosis", "Cleavage furrow formation", "Cleavage involved in rrna processing", "Cobalamin metabolic process", "Cobalamin transport", "Cobalt ion transport", "Cochlea development", "Cochlea morphogenesis", "Coenzyme a biosynthetic process", "Coenzyme a metabolic process", "Cognition", "Cohesin loading", "Collagen biosynthetic process", "Collagen catabolic process", "Collagen fibril organization", "Collagen metabolic process", "Collateral sprouting", "Collateral sprouting in absence of injury", "Collecting duct development", "Columnar cuboidal epithelial cell development", "Columnar cuboidal epithelial cell differentiation", "Columnar cuboidal epithelial cell maturation", "Commissural neuron axon guidance", "Common partner smad protein phosphorylation", "Complement activation", "Complement dependent cytotoxicity", "Connective tissue development", "Connective tissue replacement", "Constitutive heterochromatin assembly", "Constitutive secretory pathway", "Convergent extension", "Convergent extension involved in axis elongation", "Cop9 signalosome assembly", "Copi coated vesicle budding", "Copii coated vesicle budding", "Copii coated vesicle cargo loading", "Copper ion homeostasis", "Copper ion import", "Copper ion transmembrane transport", "Copper ion transport", "Coronary artery morphogenesis", "Coronary vasculature development", "Coronary vasculature morphogenesis", "Corpus callosum development", "Corpus callosum morphogenesis", "Cortical actin cytoskeleton organization", "Cortical cytoskeleton organization", "Corticospinal tract morphogenesis", "Corticosteroid hormone secretion", "Corticosteroid receptor signaling pathway", "Cortisol secretion", "Cotranslational protein targeting to membrane", "Cranial ganglion development", "Cranial nerve development", "Cranial skeletal system development", "Crd mediated mrna stabilization", "Cristae formation", "Cyclic gmp amp transmembrane import across plasma membrane", "Cyclic nucleotide catabolic process", "Cyclic nucleotide mediated signaling", "Cyclic nucleotide metabolic process", "Cyclooxygenase pathway", "Cysteine metabolic process", "Cytochrome complex assembly", "Cytokine mediated signaling pathway", "Cytokine production", "Cytokine production involved in immune response", "Cytokine production involved in inflammatory response", "Cytokinesis", "Cytokinetic process", "Cytoplasm organization", "Cytoplasmic microtubule organization", "Cytoplasmic pattern recognition receptor signaling pathway", "Cytoplasmic pattern recognition receptor signaling pathway in response to virus", "Cytoplasmic sequestering of nf kappab", "Cytoplasmic sequestering of protein", "Cytoplasmic sequestering of transcription factor", "Cytoplasmic translation", "Cytoplasmic translational elongation", "Cytoplasmic translational initiation", "Cytoskeleton dependent cytokinesis", "Cytoskeleton dependent intracellular transport", "Cytoskeleton organization", "Cytosolic calcium ion transport", "Cytosolic transport", "D amino acid transport", "Damp metabolic process", "De novo amp biosynthetic process", "De novo protein folding", "De novo pyrimidine nucleobase biosynthetic process", "Deadenylation dependent decapping of nuclear transcribed mrna", "Decidualization", "Dedifferentiation", "Defense response", "Defense response to bacterium", "Defense response to fungus", "Defense response to gram negative bacterium", "Defense response to gram positive bacterium", "Defense response to other organism", "Defense response to symbiont", "Defense response to tumor cell", "Definitive erythrocyte differentiation", "Definitive hemopoiesis", "Delamination", "Demethylation", "Dendrite arborization", "Dendrite development", "Dendrite extension", "Dendrite morphogenesis", "Dendrite self avoidance", "Dendritic cell apoptotic process", "Dendritic cell chemotaxis", "Dendritic cell cytokine production", "Dendritic cell differentiation", "Dendritic cell migration", "Dendritic spine development", "Dendritic spine maintenance", "Dendritic spine morphogenesis", "Dendritic transport", "Dense core granule transport", "Dentate gyrus development", "Deoxyribonucleoside catabolic process", "Deoxyribonucleoside diphosphate metabolic process", "Deoxyribonucleoside metabolic process", "Deoxyribonucleoside monophosphate biosynthetic process", "Deoxyribonucleoside monophosphate catabolic process", "Deoxyribonucleoside monophosphate metabolic process", "Deoxyribonucleoside triphosphate biosynthetic process", "Deoxyribonucleoside triphosphate catabolic process", "Deoxyribonucleoside triphosphate metabolic process", "Deoxyribonucleotide biosynthetic process", "Deoxyribose phosphate catabolic process", "Deoxyribose phosphate metabolic process", "Dephosphorylation", "Dephosphorylation of rna polymerase ii c terminal domain", "Depyrimidination", "Dermatan sulfate biosynthetic process", "Dermatan sulfate metabolic process", "Dermatan sulfate proteoglycan metabolic process", "Desmosome organization", "Detection of abiotic stimulus", "Detection of biotic stimulus", "Detection of calcium ion", "Detection of cell density", "Detection of external biotic stimulus", "Detection of light stimulus", "Detection of mechanical stimulus", "Detection of molecule of bacterial origin", "Detection of muscle stretch", "Detection of other organism", "Detection of stimulus", "Detection of virus", "Detection of visible light", "Determination of adult lifespan", "Determination of dorsal ventral asymmetry", "Detoxification", "Detoxification of copper ion", "Detoxification of nitrogen compound", "Development of primary female sexual characteristics", "Development of primary sexual characteristics", "Development of secondary female sexual characteristics", "Development of secondary sexual characteristics", "Developmental cell growth", "Developmental growth", "Developmental growth involved in morphogenesis", "Developmental induction", "Developmental maturation", "Developmental pigmentation", "Developmental process involved in reproduction", "Diacylglycerol biosynthetic process", "Diacylglycerol metabolic process", "Diadenosine polyphosphate catabolic process", "Diadenosine polyphosphate metabolic process", "Diapedesis", "Diaphragm development", "Dicarboxylic acid biosynthetic process", "Dicarboxylic acid catabolic process", "Dicarboxylic acid metabolic process", "Dicarboxylic acid transport", "Diencephalon development", "Diet induced thermogenesis", "Digestion", "Digestive system development", "Digestive system process", "Digestive tract morphogenesis", "Diol biosynthetic process", "Diol metabolic process", "Diphosphoinositol polyphosphate metabolic process", "Disaccharide metabolic process", "Diterpenoid biosynthetic process", "Divalent inorganic cation homeostasis", "Dna biosynthetic process", "Dna catabolic process", "Dna catabolic process endonucleolytic", "Dna catabolic process exonucleolytic", "Dna conformation change", "Dna damage response signal transduction by p53 class mediator", "Dna damage response signal transduction by p53 class mediator resulting in cell cycle arrest", "Dna damage response signal transduction resulting in transcription", "Dna dealkylation", "Dna dealkylation involved in dna repair", "Dna deamination", "Dna dependent dna replication", "Dna dependent dna replication maintenance of fidelity", "Dna double strand break processing", "Dna endoreduplication", "Dna geometric change", "Dna integration", "Dna integrity checkpoint signaling", "Dna ligation", "Dna ligation involved in dna repair", "Dna metabolic process", "Dna methylation", "Dna methylation dependent heterochromatin assembly", "Dna methylation involved in gamete generation", "Dna methylation on cytosine", "Dna methylation or demethylation", "Dna modification", "Dna packaging", "Dna protection", "Dna recombination", "Dna repair", "Dna replication", "Dna replication checkpoint signaling", "Dna replication dependent chromatin organization", "Dna replication independent chromatin organization", "Dna replication initiation", "Dna replication synthesis of rna primer", "Dna strand elongation", "Dna strand elongation involved in dna replication", "Dna synthesis involved in dna repair", "Dna templated transcription elongation", "Dna templated transcription initiation", "Dna templated transcription termination", "Dna topological change", "Dna unwinding involved in dna replication", "Dolichol metabolic process", "Dolichyl diphosphate biosynthetic process", "Dopamine biosynthetic process", "Dopamine metabolic process", "Dopamine receptor signaling pathway", "Dopamine transport", "Dopaminergic neuron differentiation", "Dorsal root ganglion development", "Dorsal ventral axis specification", "Dorsal ventral neural tube patterning", "Dorsal ventral pattern formation", "Dosage compensation", "Double strand break repair", "Double strand break repair involved in meiotic recombination", "Double strand break repair via break induced replication", "Double strand break repair via classical nonhomologous end joining", "Double strand break repair via nonhomologous end joining", "Dsrna processing", "Dtmp metabolic process", "Dttp metabolic process", "Dump metabolic process", "Ear development", "Ear morphogenesis", "Early endosome to golgi transport", "Eating behavior", "Ectoderm development", "Ectodermal cell differentiation", "Ectodermal placode development", "Ectopic germ cell programmed cell death", "Egg activation", "Electron transport chain", "Embryo development", "Embryo development ending in birth or egg hatching", "Embryo implantation", "Embryonic appendage morphogenesis", "Embryonic axis specification", "Embryonic body morphogenesis", "Embryonic brain development", "Embryonic camera type eye development", "Embryonic cleavage", "Embryonic cranial skeleton morphogenesis", "Embryonic digestive tract development", "Embryonic digit morphogenesis", "Embryonic forelimb morphogenesis", "Embryonic heart tube development", "Embryonic heart tube morphogenesis", "Embryonic hemopoiesis", "Embryonic hindlimb morphogenesis", "Embryonic morphogenesis", "Embryonic neurocranium morphogenesis", "Embryonic organ development", "Embryonic organ morphogenesis", "Embryonic pattern specification", "Embryonic placenta development", "Embryonic placenta morphogenesis", "Embryonic process involved in female pregnancy", "Embryonic skeletal joint development", "Embryonic skeletal joint morphogenesis", "Embryonic skeletal system development", "Embryonic skeletal system morphogenesis", "Embryonic viscerocranium morphogenesis", "Enamel mineralization", "Endocannabinoid signaling pathway", "Endocardium development", "Endochondral bone morphogenesis", "Endocrine hormone secretion", "Endocrine pancreas development", "Endocrine process", "Endocrine system development", "Endocytic recycling", "Endocytosis", "Endoderm development", "Endoderm formation", "Endodermal cell differentiation", "Endodermal cell fate commitment", "Endomembrane system organization", "Endonucleolytic cleavage in 5 ets of tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna", "Endonucleolytic cleavage in its1 to separate ssu rrna from 5 8s rrna and lsu rrna from tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna", "Endonucleolytic cleavage involved in rrna processing", "Endoplasmic reticulum calcium ion homeostasis", "Endoplasmic reticulum localization", "Endoplasmic reticulum mannose trimming", "Endoplasmic reticulum membrane organization", "Endoplasmic reticulum organization", "Endoplasmic reticulum plasma membrane tethering", "Endoplasmic reticulum to cytosol transport", "Endoplasmic reticulum to golgi vesicle mediated transport", "Endoplasmic reticulum tubular network organization", "Endoplasmic reticulum unfolded protein response", "Endosomal lumen acidification", "Endosomal transport", "Endosomal vesicle fusion", "Endosome organization", "Endosome to lysosome transport", "Endosome to lysosome transport via multivesicular body sorting pathway", "Endosome to plasma membrane protein transport", "Endosome transport via multivesicular body sorting pathway", "Endothelial cell activation", "Endothelial cell apoptotic process", "Endothelial cell chemotaxis", "Endothelial cell development", "Endothelial cell migration", "Endothelial cell morphogenesis", "Endothelial cell proliferation", "Endothelin receptor signaling pathway", "Endothelium development", "Energy derivation by oxidation of organic compounds", "Energy homeostasis", "Energy reserve metabolic process", "Engulfment of apoptotic cell", "Ensheathment of neurons", "Enteroendocrine cell differentiation", "Entrainment of circadian clock", "Entry into host", "Entry of bacterium into host cell", "Enzyme directed rrna pseudouridine synthesis", "Enzyme linked receptor protein signaling pathway", "Eosinophil activation", "Eosinophil mediated immunity", "Ephrin receptor signaling pathway", "Epiboly", "Epidermal cell differentiation", "Epidermis development", "Epidermis morphogenesis", "Epigenetic maintenance of chromatin in transcription competent conformation", "Epithelial cell apoptotic process", "Epithelial cell cell adhesion", "Epithelial cell development", "Epithelial cell differentiation", "Epithelial cell differentiation involved in kidney development", "Epithelial cell differentiation involved in prostate gland development", "Epithelial cell maturation", "Epithelial cell morphogenesis", "Epithelial cell proliferation", "Epithelial cell proliferation involved in lung morphogenesis", "Epithelial cell proliferation involved in prostate gland development", "Epithelial fluid transport", "Epithelial structure maintenance", "Epithelial to mesenchymal transition", "Epithelial tube branching involved in lung morphogenesis", "Epithelial tube formation", "Epithelial tube morphogenesis", "Epithelium development", "Epoxide metabolic process", "Er associated misfolded protein catabolic process", "Er nucleus signaling pathway", "Er overload response", "Erad pathway", "Erbb signaling pathway", "Erbb2 signaling pathway", "Erk1 and erk2 cascade", "Error free translesion synthesis", "Error prone translesion synthesis", "Erythrocyte development", "Erythrocyte homeostasis", "Erythrocyte maturation", "Escrt complex disassembly", "Establishment of cell polarity", "Establishment of centrosome localization", "Establishment of endothelial barrier", "Establishment of endothelial intestinal barrier", "Establishment of epithelial cell apical basal polarity", "Establishment of epithelial cell polarity", "Establishment of golgi localization", "Establishment of lymphocyte polarity", "Establishment of meiotic spindle localization", "Establishment of mitochondrion localization", "Establishment of mitotic spindle localization", "Establishment of organelle localization", "Establishment of pigment granule localization", "Establishment of planar polarity involved in neural tube closure", "Establishment of planar polarity of embryonic epithelium", "Establishment of protein localization", "Establishment of protein localization to chromatin", "Establishment of protein localization to chromosome", "Establishment of protein localization to endoplasmic reticulum", "Establishment of protein localization to membrane", "Establishment of protein localization to mitochondrial membrane", "Establishment of protein localization to organelle", "Establishment of protein localization to plasma membrane", "Establishment of protein localization to telomere", "Establishment of protein localization to vacuole", "Establishment of rna localization", "Establishment of sister chromatid cohesion", "Establishment of spindle orientation", "Establishment of tissue polarity", "Establishment or maintenance of bipolar cell polarity", "Establishment or maintenance of cell polarity", "Establishment or maintenance of cytoskeleton polarity", "Establishment or maintenance of monopolar cell polarity", "Establishment or maintenance of transmembrane electrochemical gradient", "Estrogen biosynthetic process", "Estrogen metabolic process", "Estrous cycle", "Ethanol catabolic process", "Ethanol metabolic process", "Ethanol oxidation", "Ethanolamine containing compound metabolic process", "Ether biosynthetic process", "Ether metabolic process", "Excretion", "Execution phase of apoptosis", "Exit from mitosis", "Exocrine pancreas development", "Exocrine system development", "Exocyst localization", "Exocytic process", "Exocytosis", "Exonucleolytic catabolism of deadenylated mrna", "Exploration behavior", "Export across plasma membrane", "Export from cell", "External encapsulating structure organization", "Extracellular exosome assembly", "Extracellular matrix assembly", "Extracellular matrix constituent secretion", "Extracellular matrix disassembly", "Extracellular regulation of signal transduction", "Extracellular transport", "Extracellular vesicle biogenesis", "Extraembryonic membrane development", "Extrinsic apoptotic signaling pathway", "Extrinsic apoptotic signaling pathway via death domain receptors", "Eye morphogenesis", "Eye photoreceptor cell development", "Eye photoreceptor cell differentiation", "Eye pigmentation", "Eyelid development in camera type eye", "Face development", "Facultative heterochromatin assembly", "Farnesyl diphosphate metabolic process", "Fas signaling pathway", "Fat cell differentiation", "Fat cell proliferation", "Fat soluble vitamin metabolic process", "Fatty acid alpha oxidation", "Fatty acid beta oxidation", "Fatty acid beta oxidation using acyl coa dehydrogenase", "Fatty acid beta oxidation using acyl coa oxidase", "Fatty acid biosynthetic process", "Fatty acid catabolic process", "Fatty acid derivative biosynthetic process", "Fatty acid derivative catabolic process", "Fatty acid derivative metabolic process", "Fatty acid elongation", "Fatty acid homeostasis", "Fatty acid metabolic process", "Fatty acid omega oxidation", "Fatty acid transmembrane transport", "Fatty acid transport", "Fatty acyl coa biosynthetic process", "Fatty acyl coa catabolic process", "Fatty acyl coa metabolic process", "Fc epsilon receptor signaling pathway", "Fc gamma receptor signaling pathway", "Fc receptor mediated stimulatory signaling pathway", "Fc receptor signaling pathway", "Fear response", "Feeding behavior", "Female gamete generation", "Female genitalia development", "Female meiosis chromosome segregation", "Female meiosis i", "Female meiotic nuclear division", "Female sex differentiation", "Fermentation", "Fertilization", "Fibroblast activation", "Fibroblast apoptotic process", "Fibroblast growth factor receptor signaling pathway", "Fibroblast migration", "Fibroblast proliferation", "Filopodium assembly", "Flavin containing compound metabolic process", "Flavonoid metabolic process", "Fluid transport", "Foam cell differentiation", "Focal adhesion assembly", "Folate import across plasma membrane", "Folate transmembrane transport", "Folic acid containing compound biosynthetic process", "Folic acid containing compound catabolic process", "Folic acid containing compound metabolic process", "Folic acid metabolic process", "Folic acid transport", "Forebrain cell migration", "Forebrain development", "Forebrain generation of neurons", "Forebrain morphogenesis", "Forebrain neuron development", "Forebrain neuron differentiation", "Forebrain radial glial cell differentiation", "Forebrain regionalization", "Foregut morphogenesis", "Forelimb morphogenesis", "Formate metabolic process", "Formation of extrachromosomal circular dna", "Formation of primary germ layer", "Formation of translation preinitiation complex", "Free ubiquitin chain polymerization", "Fructose 1 6 bisphosphate metabolic process", "Fructose 2 6 bisphosphate metabolic process", "Fructose 6 phosphate metabolic process", "Fructose metabolic process", "Fucose metabolic process", "Fucosylation", "Fungiform papilla development", "Fungiform papilla morphogenesis", "G protein coupled acetylcholine receptor signaling pathway", "G protein coupled opioid receptor signaling pathway", "G protein coupled purinergic receptor signaling pathway", "G protein coupled receptor internalization", "G protein coupled receptor signaling pathway", "G protein coupled receptor signaling pathway coupled to cyclic nucleotide second messenger", "G protein coupled receptor signaling pathway involved in heart process", "G quadruplex dna unwinding", "G0 to g1 transition", "G1 to g0 transition", "Galactolipid biosynthetic process", "Galactolipid metabolic process", "Galactose catabolic process", "Galactose metabolic process", "Gamete generation", "Gamma aminobutyric acid metabolic process", "Gamma aminobutyric acid secretion", "Gamma aminobutyric acid signaling pathway", "Gamma aminobutyric acid transport", "Ganglion development", "Ganglioside catabolic process", "Ganglioside metabolic process", "Gap junction assembly", "Gap junction mediated intercellular transport", "Gas homeostasis", "Gastrulation", "Gastrulation with mouth forming second", "Gdp mannose metabolic process", "Gdp metabolic process", "Gene silencing by rna", "Generation of precursor metabolites and energy", "Genitalia development", "Genitalia morphogenesis", "Genomic imprinting", "Germ cell development", "Germ cell migration", "Germ cell proliferation", "Germinal center formation", "Gland development", "Gland morphogenesis", "Glandular epithelial cell development", "Glandular epithelial cell differentiation", "Glial cell apoptotic process", "Glial cell development", "Glial cell differentiation", "Glial cell fate commitment", "Glial cell migration", "Glial cell proliferation", "Gliogenesis", "Glomerular basement membrane development", "Glomerular epithelial cell development", "Glomerular epithelial cell differentiation", "Glomerular epithelium development", "Glomerular visceral epithelial cell migration", "Glomerulus development", "Glucan biosynthetic process", "Glucocorticoid biosynthetic process", "Glucocorticoid metabolic process", "Glucocorticoid secretion", "Glucosamine containing compound catabolic process", "Glucosamine containing compound metabolic process", "Glucose 6 phosphate metabolic process", "Glucose catabolic process", "Glucose import", "Glucose import in response to insulin stimulus", "Glucose metabolic process", "Glucosylceramide metabolic process", "Glutamate biosynthetic process", "Glutamate catabolic process", "Glutamate homeostasis", "Glutamate metabolic process", "Glutamate receptor signaling pathway", "Glutamate reuptake", "Glutamate secretion", "Glutamate secretion neurotransmission", "Glutamine family amino acid biosynthetic process", "Glutamine family amino acid catabolic process", "Glutamine family amino acid metabolic process", "Glutamine metabolic process", "Glutamine transport", "Glutathione catabolic process", "Glutathione metabolic process", "Glycerol 3 phosphate metabolic process", "Glycerol ether metabolic process", "Glycerolipid biosynthetic process", "Glycerolipid catabolic process", "Glycerolipid metabolic process", "Glycerophospholipid biosynthetic process", "Glycerophospholipid catabolic process", "Glycerophospholipid metabolic process", "Glycine biosynthetic process", "Glycine metabolic process", "Glycolipid biosynthetic process", "Glycolipid catabolic process", "Glycolipid transport", "Glycolytic fermentation", "Glycolytic process through fructose 6 phosphate", "Glycoprotein biosynthetic process", "Glycoprotein catabolic process", "Glycoprotein metabolic process", "Glycosaminoglycan catabolic process", "Glycoside catabolic process", "Glycoside metabolic process", "Glycosphingolipid biosynthetic process", "Glycosphingolipid metabolic process", "Glycosyl compound biosynthetic process", "Glycosyl compound catabolic process", "Glycosyl compound metabolic process", "Glycosylation", "Glycosylceramide biosynthetic process", "Glycosylceramide catabolic process", "Glycosylceramide metabolic process", "Glyoxylate metabolic process", "Gmp biosynthetic process", "Gmp metabolic process", "Gmp salvage", "Golgi disassembly", "Golgi localization", "Golgi organization", "Golgi ribbon formation", "Golgi to endosome transport", "Golgi to lysosome transport", "Golgi to plasma membrane protein transport", "Golgi to plasma membrane transport", "Golgi to vacuole transport", "Golgi vesicle budding", "Golgi vesicle transport", "Gonadotropin secretion", "Gpi anchor metabolic process", "Granulocyte activation", "Granulocyte chemotaxis", "Granulocyte differentiation", "Granulocyte migration", "Granzyme mediated programmed cell death signaling pathway", "Grooming behavior", "Growth", "Growth hormone receptor signaling pathway via jak stat", "Growth hormone secretion", "Growth plate cartilage chondrocyte differentiation", "Growth plate cartilage development", "Gtp biosynthetic process", "Gtp metabolic process", "Guanine metabolic process", "Guanine nucleotide transmembrane transport", "Guanine nucleotide transport", "Hair cell differentiation", "Hair cycle phase", "Hair follicle maturation", "Hair follicle placode formation", "Head development", "Head morphogenesis", "Heart development", "Heart formation", "Heart growth", "Heart morphogenesis", "Heart process", "Heart trabecula formation", "Heart trabecula morphogenesis", "Heart valve development", "Heart valve morphogenesis", "Heat acclimation", "Hematopoietic progenitor cell differentiation", "Hematopoietic stem cell differentiation", "Hematopoietic stem cell homeostasis", "Hematopoietic stem cell proliferation", "Heme transport", "Hemidesmosome assembly", "Hemoglobin biosynthetic process", "Hemoglobin metabolic process", "Hemostasis", "Heparan sulfate proteoglycan biosynthetic process", "Heparan sulfate proteoglycan biosynthetic process enzymatic modification", "Heparan sulfate proteoglycan biosynthetic process polysaccharide chain biosynthetic process", "Heparan sulfate proteoglycan metabolic process", "Hepatic stellate cell activation", "Hepaticobiliary system development", "Hepatocyte apoptotic process", "Hepatocyte differentiation", "Hepatocyte growth factor receptor signaling pathway", "Heterochromatin organization", "Heterophilic cell cell adhesion via plasma membrane cell adhesion molecules", "Heterotypic cell cell adhesion", "High density lipoprotein particle assembly", "High density lipoprotein particle clearance", "High density lipoprotein particle remodeling", "Hindbrain development", "Hindbrain maturation", "Hindbrain morphogenesis", "Hindbrain radial glia guided cell migration", "Hindlimb morphogenesis", "Hippo signaling", "Hippocampus development", "His purkinje system development", "Histamine production involved in inflammatory response", "Histamine secretion", "Histamine transport", "Histidine metabolic process", "Histone arginine methylation", "Histone deacetylation", "Histone dephosphorylation", "Histone deubiquitination", "Histone exchange", "Histone h2a acetylation", "Histone h2a k63 linked ubiquitination", "Histone h2a monoubiquitination", "Histone h2a phosphorylation", "Histone h2a ubiquitination", "Histone h2b ubiquitination", "Histone h3 acetylation", "Histone h3 deacetylation", "Histone h3 k14 acetylation", "Histone h3 k27 methylation", "Histone h3 k27 trimethylation", "Histone h3 k36 demethylation", "Histone h3 k36 methylation", "Histone h3 k4 demethylation", "Histone h3 k4 dimethylation", "Histone h3 k4 methylation", "Histone h3 k4 monomethylation", "Histone h3 k4 trimethylation", "Histone h3 k9 acetylation", "Histone h3 k9 demethylation", "Histone h3 k9 dimethylation", "Histone h3 k9 methylation", "Histone h3 k9 modification", "Histone h3 k9 trimethylation", "Histone h4 acetylation", "Histone h4 deacetylation", "Histone h4 k12 acetylation", "Histone h4 k16 acetylation", "Histone h4 k20 methylation", "Histone h4 k20 trimethylation", "Histone h4 k5 acetylation", "Histone h4 r3 methylation", "Histone lysine demethylation", "Histone methylation", "Histone modification", "Histone monoubiquitination", "Histone mrna catabolic process", "Histone mrna metabolic process", "Histone phosphorylation", "Histone serine phosphorylation", "Histone threonine phosphorylation", "Histone ubiquitination", "Homeostasis of number of cells", "Homeostasis of number of cells within a tissue", "Homeostatic process", "Homocysteine metabolic process", "Homologous chromosome pairing at meiosis", "Homologous chromosome segregation", "Homologous recombination", "Homophilic cell adhesion via plasma membrane adhesion molecules", "Homotypic cell cell adhesion", "Hormone biosynthetic process", "Hormone catabolic process", "Hormone mediated signaling pathway", "Hormone metabolic process", "Hormone transport", "Humoral immune response", "Humoral immune response mediated by circulating immunoglobulin", "Hyaluronan biosynthetic process", "Hyaluronan metabolic process", "Hydrogen peroxide biosynthetic process", "Hydrogen peroxide catabolic process", "Hydrogen peroxide metabolic process", "Hydrogen sulfide biosynthetic process", "Hydrogen sulfide metabolic process", "Hyperosmotic response", "Hyperosmotic salinity response", "Hypothalamus cell differentiation", "Hypothalamus development", "Hypotonic response", "Hypoxia inducible factor 1alpha signaling pathway", "I kappab kinase nf kappab signaling", "I kappab phosphorylation", "Icosanoid biosynthetic process", "Icosanoid metabolic process", "Icosanoid transport", "Immune complex clearance", "Immune effector process", "Immune response", "Immune response regulating cell surface receptor signaling pathway", "Immune response regulating signaling pathway", "Immune response to tumor cell", "Immune system development", "Immunoglobulin production", "Immunoglobulin production involved in immunoglobulin mediated immune response", "Immunoglobulin v d j recombination", "Immunological synapse formation", "Imp biosynthetic process", "Imp catabolic process", "Imp metabolic process", "Imp salvage", "Import across plasma membrane", "Import into cell", "Import into nucleus", "In utero embryonic development", "Inclusion body assembly", "Indolalkylamine metabolic process", "Indole containing compound biosynthetic process", "Indole containing compound metabolic process", "Inflammasome complex assembly", "Inflammatory cell apoptotic process", "Inflammatory response", "Inflammatory response to antigenic stimulus", "Inflammatory response to wounding", "Innate immune response", "Innate immune response activating signal transduction", "Innate immune response in mucosa", "Inner cell mass cell differentiation", "Inner cell mass cell proliferation", "Inner dynein arm assembly", "Inner ear auditory receptor cell differentiation", "Inner ear morphogenesis", "Inner ear receptor cell development", "Inner ear receptor cell stereocilium organization", "Inner mitochondrial membrane organization", "Innervation", "Inorganic anion transmembrane transport", "Inorganic anion transport", "Inorganic ion import across plasma membrane", "Inorganic ion transmembrane transport", "Inosine metabolic process", "Inositol lipid mediated signaling", "Inositol metabolic process", "Inositol phosphate catabolic process", "Inositol phosphate mediated signaling", "Inositol phosphate metabolic process", "Insulin like growth factor receptor signaling pathway", "Insulin metabolic process", "Insulin processing", "Insulin receptor signaling pathway", "Insulin secretion", "Insulin secretion involved in cellular response to glucose stimulus", "Integrated stress response signaling", "Integrin activation", "Integrin mediated signaling pathway", "Intercellular transport", "Interferon alpha production", "Interferon beta production", "Interferon gamma mediated signaling pathway", "Interferon gamma production", "Interleukin 1 alpha production", "Interleukin 1 mediated signaling pathway", "Interleukin 1 production", "Interleukin 10 production", "Interleukin 12 production", "Interleukin 13 production", "Interleukin 17 production", "Interleukin 18 production", "Interleukin 2 production", "Interleukin 23 production", "Interleukin 27 mediated signaling pathway", "Interleukin 6 mediated signaling pathway", "Interleukin 6 production", "Interleukin 8 production", "Intermediate filament based process", "Intermediate filament bundle assembly", "Intermediate filament organization", "Intermembrane lipid transfer", "Interstrand cross link repair", "Intestinal absorption", "Intestinal epithelial cell development", "Intestinal epithelial cell differentiation", "Intestinal hexose absorption", "Intestinal lipid absorption", "Intra golgi vesicle mediated transport", "Intracellular distribution of mitochondria", "Intracellular estrogen receptor signaling pathway", "Intracellular lipid transport", "Intracellular mrna localization", "Intracellular protein transmembrane transport", "Intracellular protein transport", "Intracellular receptor signaling pathway", "Intracellular sterol transport", "Intracellular transport", "Intracellular transport of virus", "Intraciliary retrograde transport", "Intraciliary transport", "Intraciliary transport involved in cilium assembly", "Intrinsic apoptotic signaling pathway", "Intrinsic apoptotic signaling pathway by p53 class mediator", "Intrinsic apoptotic signaling pathway in response to dna damage", "Intrinsic apoptotic signaling pathway in response to dna damage by p53 class mediator", "Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress", "Intrinsic apoptotic signaling pathway in response to hydrogen peroxide", "Intrinsic apoptotic signaling pathway in response to hypoxia", "Intrinsic apoptotic signaling pathway in response to osmotic stress", "Intrinsic apoptotic signaling pathway in response to oxidative stress", "Ion homeostasis", "Ion transmembrane transport", "Ion transport", "Ire1 mediated unfolded protein response", "Ires dependent viral translational initiation", "Iron coordination entity transport", "Iron import into cell", "Iron ion homeostasis", "Iron ion transmembrane transport", "Iron ion transport", "Iron sulfur cluster assembly", "Isocitrate metabolic process", "Isoleucine metabolic process", "Isopentenyl diphosphate biosynthetic process", "Isoprenoid biosynthetic process", "Isoprenoid metabolic process", "Isotype switching to iga isotypes", "Isotype switching to igg isotypes", "Jnk cascade", "Keratan sulfate metabolic process", "Keratinocyte development", "Keratinocyte differentiation", "Keratinocyte migration", "Keratinocyte proliferation", "Ketone biosynthetic process", "Ketone body biosynthetic process", "Ketone body metabolic process", "Ketone catabolic process", "Kidney epithelium development", "Kidney mesenchyme development", "Kidney morphogenesis", "Killing by host of symbiont cells", "Killing of cells of another organism", "Kinetochore assembly", "Kinetochore organization", "Kynurenine metabolic process", "L alanine transport", "L alpha amino acid transmembrane transport", "L amino acid transport", "L ascorbic acid metabolic process", "L aspartate transmembrane transport", "L glutamate import across plasma membrane", "L glutamate transmembrane transport", "L kynurenine metabolic process", "L methionine salvage from methylthioadenosine", "L phenylalanine metabolic process", "L proline biosynthetic process", "L serine biosynthetic process", "L serine catabolic process", "L serine metabolic process", "L serine transport", "Labyrinthine layer blood vessel development", "Labyrinthine layer development", "Labyrinthine layer morphogenesis", "Lactate metabolic process", "Lactate transmembrane transport", "Lactation", "Lamellipodium assembly", "Lamellipodium morphogenesis", "Lamellipodium organization", "Late endosome to golgi transport", "Late endosome to lysosome transport", "Late endosome to vacuole transport", "Late endosome to vacuole transport via multivesicular body sorting pathway", "Late nucleophagy", "Lateral ventricle development", "Layer formation in cerebral cortex", "Learning", "Left right axis specification", "Left right pattern formation", "Lens development in camera type eye", "Lens fiber cell development", "Lens fiber cell differentiation", "Lens morphogenesis in camera type eye", "Leptin mediated signaling pathway", "Leucine catabolic process", "Leucine import across plasma membrane", "Leucine metabolic process", "Leucine transport", "Leukocyte adhesion to vascular endothelial cell", "Leukocyte aggregation", "Leukocyte apoptotic process", "Leukocyte cell cell adhesion", "Leukocyte chemotaxis", "Leukocyte degranulation", "Leukocyte differentiation", "Leukocyte homeostasis", "Leukocyte mediated cytotoxicity", "Leukocyte mediated immunity", "Leukocyte migration", "Leukocyte proliferation", "Leukocyte tethering or rolling", "Leukotriene b4 metabolic process", "Leukotriene biosynthetic process", "Leukotriene metabolic process", "Leukotriene transport", "Leydig cell differentiation", "Ligand gated ion channel signaling pathway", "Limb joint morphogenesis", "Limbic system development", "Linoleic acid metabolic process", "Lipid biosynthetic process", "Lipid catabolic process", "Lipid digestion", "Lipid droplet formation", "Lipid droplet organization", "Lipid export from cell", "Lipid glycosylation", "Lipid homeostasis", "Lipid import into cell", "Lipid localization", "Lipid metabolic process", "Lipid modification", "Lipid oxidation", "Lipid phosphorylation", "Lipid storage", "Lipid translocation", "Lipid transport across blood brain barrier", "Lipophagy", "Lipopolysaccharide mediated signaling pathway", "Lipoprotein biosynthetic process", "Lipoprotein catabolic process", "Lipoprotein localization", "Lipoprotein metabolic process", "Liposaccharide metabolic process", "Lipoxin metabolic process", "Liver morphogenesis", "Liver regeneration", "Localization within membrane", "Locomotion", "Locomotion involved in locomotory behavior", "Locomotor rhythm", "Locomotory behavior", "Locomotory exploration behavior", "Long chain fatty acid biosynthetic process", "Long chain fatty acid import across plasma membrane", "Long chain fatty acid metabolic process", "Long chain fatty acid transport", "Long chain fatty acyl coa biosynthetic process", "Long chain fatty acyl coa metabolic process", "Long term memory", "Long term synaptic depression", "Long term synaptic potentiation", "Low density lipoprotein particle clearance", "Low density lipoprotein receptor particle metabolic process", "Lung alveolus development", "Lung associated mesenchyme development", "Lung cell differentiation", "Lung epithelium development", "Lung growth", "Lung lobe development", "Lung morphogenesis", "Lung saccule development", "Lung secretory cell differentiation", "Luteinization", "Luteinizing hormone secretion", "Luteolysis", "Lymphocyte activation", "Lymphocyte activation involved in immune response", "Lymphocyte aggregation", "Lymphocyte anergy", "Lymphocyte apoptotic process", "Lymphocyte chemotaxis", "Lymphocyte costimulation", "Lymphocyte homeostasis", "Lymphocyte mediated immunity", "Lymphocyte migration", "Lymphoid progenitor cell differentiation", "Lysine catabolic process", "Lysine metabolic process", "Lysosomal lumen acidification", "Lysosomal membrane organization", "Lysosomal microautophagy", "Lysosomal protein catabolic process", "Lysosomal transport", "Lytic vacuole organization", "Macroautophagy", "Macromolecule catabolic process", "Macromolecule deacylation", "Macromolecule depalmitoylation", "Macrophage activation", "Macrophage apoptotic process", "Macrophage chemotaxis", "Macrophage cytokine production", "Macrophage differentiation", "Macrophage migration", "Macrophage proliferation", "Macropinocytosis", "Magnesium ion homeostasis", "Magnesium ion transport", "Maintenance of apical basal cell polarity", "Maintenance of blood brain barrier", "Maintenance of cell number", "Maintenance of cell polarity", "Maintenance of centrosome location", "Maintenance of dna methylation", "Maintenance of dna repeat elements", "Maintenance of gastrointestinal epithelium", "Maintenance of lens transparency", "Maintenance of location", "Maintenance of location in cell", "Maintenance of organelle location", "Maintenance of postsynaptic specialization structure", "Maintenance of presynaptic active zone structure", "Maintenance of protein localization in endoplasmic reticulum", "Maintenance of protein localization in organelle", "Maintenance of protein location", "Maintenance of protein location in cell", "Maintenance of protein location in mitochondrion", "Maintenance of protein location in nucleus", "Maintenance of sister chromatid cohesion", "Maintenance of synapse structure", "Malate metabolic process", "Male gamete generation", "Male genitalia development", "Male mating behavior", "Male meiosis i", "Male meiotic nuclear division", "Male sex determination", "Male sex differentiation", "Malonyl coa metabolic process", "Mammalian oogenesis stage", "Mammary gland alveolus development", "Mammary gland development", "Mammary gland duct morphogenesis", "Mammary gland epithelial cell differentiation", "Mammary gland epithelial cell proliferation", "Mammary gland epithelium development", "Mammary gland involution", "Mammary gland morphogenesis", "Manganese ion transmembrane transport", "Manganese ion transport", "Mannose metabolic process", "Mannosylation", "Mapk cascade", "Mast cell activation", "Mast cell activation involved in immune response", "Mast cell cytokine production", "Maternal placenta development", "Maternal process involved in female pregnancy", "Mating", "Mating behavior", "Maturation of 5 8s rrna", "Maturation of 5 8s rrna from tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna", "Maturation of lsu rrna", "Maturation of lsu rrna from tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna", "Maturation of ssu rrna", "Maturation of ssu rrna from tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna", "Mature ribosome assembly", "Mda 5 signaling pathway", "Mechanoreceptor differentiation", "Mechanosensory behavior", "Medium chain fatty acid biosynthetic process", "Medium chain fatty acid catabolic process", "Medium chain fatty acid metabolic process", "Medium chain fatty acyl coa metabolic process", "Megakaryocyte development", "Megakaryocyte differentiation", "Meiosis i cell cycle process", "Meiosis ii cell cycle process", "Meiotic cell cycle", "Meiotic cell cycle checkpoint signaling", "Meiotic cell cycle phase transition", "Meiotic cell cycle process", "Meiotic chromosome condensation", "Meiotic chromosome segregation", "Meiotic chromosome separation", "Meiotic cytokinesis", "Meiotic dna double strand break formation", "Meiotic sister chromatid cohesion centromeric", "Meiotic spindle assembly", "Meiotic spindle organization", "Melanocyte differentiation", "Membrane biogenesis", "Membrane depolarization", "Membrane depolarization during action potential", "Membrane disassembly", "Membrane docking", "Membrane fission", "Membrane fusion", "Membrane hyperpolarization", "Membrane invagination", "Membrane lipid biosynthetic process", "Membrane lipid catabolic process", "Membrane lipid metabolic process", "Membrane organization", "Membrane protein ectodomain proteolysis", "Membrane protein intracellular domain proteolysis", "Membrane protein proteolysis", "Membrane raft assembly", "Membrane raft localization", "Membrane raft organization", "Membrane repolarization", "Membrane repolarization during action potential", "Membrane repolarization during atrial cardiac muscle cell action potential", "Membrane repolarization during cardiac muscle cell action potential", "Membrane to membrane docking", "Membranous septum morphogenesis", "Memory", "Mesangial cell development", "Mesangial cell differentiation", "Mesenchymal cell development", "Mesenchymal cell differentiation", "Mesenchymal cell differentiation involved in kidney development", "Mesenchymal cell proliferation", "Mesenchymal cell proliferation involved in lung development", "Mesenchymal stem cell differentiation", "Mesenchymal stem cell proliferation", "Mesenchymal to epithelial transition", "Mesenchymal to epithelial transition involved in metanephros morphogenesis", "Mesenchyme development", "Mesenchyme morphogenesis", "Mesoderm development", "Mesoderm morphogenesis", "Mesodermal cell differentiation", "Mesonephric duct development", "Mesonephric tubule formation", "Mesonephric tubule morphogenesis", "Mesonephros development", "Metal ion export", "Metal ion homeostasis", "Metal ion transport", "Metanephric collecting duct development", "Metanephric epithelium development", "Metanephric glomerulus development", "Metanephric glomerulus vasculature development", "Metanephric mesenchymal cell differentiation", "Metanephric mesenchyme development", "Metanephric nephron development", "Metanephric nephron morphogenesis", "Metanephric nephron tubule epithelial cell differentiation", "Metanephric part of ureteric bud development", "Metanephric renal vesicle morphogenesis", "Metanephric tubule development", "Metanephros development", "Metanephros morphogenesis", "Metaphase anaphase transition of cell cycle", "Metaphase plate congression", "Metencephalon development", "Methionine biosynthetic process", "Methionine metabolic process", "Methylation", "Methylglyoxal metabolic process", "Methylguanosine cap decapping", "Mhc class i biosynthetic process", "Mhc class ii biosynthetic process", "Microglia differentiation", "Microglial cell activation", "Microglial cell proliferation", "Microtubule anchoring", "Microtubule anchoring at centrosome", "Microtubule anchoring at microtubule organizing center", "Microtubule based movement", "Microtubule based process", "Microtubule based transport", "Microtubule bundle formation", "Microtubule cytoskeleton organization", "Microtubule cytoskeleton organization involved in mitosis", "Microtubule depolymerization", "Microtubule nucleation", "Microtubule organizing center localization", "Microtubule organizing center organization", "Microtubule polymerization", "Microtubule polymerization or depolymerization", "Microvillus assembly", "Microvillus organization", "Midbody abscission", "Midbrain development", "Midbrain dopaminergic neuron differentiation", "Middle ear morphogenesis", "Minus end directed organelle transport along microtubule", "Mirna catabolic process", "Mirna loading onto risc involved in gene silencing by mirna", "Mirna metabolic process", "Mismatch repair", "Mitochondrial acetyl coa biosynthetic process from pyruvate", "Mitochondrial adp transmembrane transport", "Mitochondrial atp synthesis coupled proton transport", "Mitochondrial calcium ion homeostasis", "Mitochondrial calcium ion transmembrane transport", "Mitochondrial cytochrome c oxidase assembly", "Mitochondrial depolarization", "Mitochondrial dna metabolic process", "Mitochondrial dna repair", "Mitochondrial dna replication", "Mitochondrial electron transport cytochrome c to oxygen", "Mitochondrial electron transport nadh to ubiquinone", "Mitochondrial electron transport ubiquinol to cytochrome c", "Mitochondrial fission", "Mitochondrial fragmentation involved in apoptotic process", "Mitochondrial fusion", "Mitochondrial gene expression", "Mitochondrial genome maintenance", "Mitochondrial membrane organization", "Mitochondrial outer membrane permeabilization", "Mitochondrial outer membrane permeabilization involved in programmed cell death", "Mitochondrial protein catabolic process", "Mitochondrial protein processing", "Mitochondrial proton transporting atp synthase complex assembly", "Mitochondrial respirasome assembly", "Mitochondrial respiratory chain complex assembly", "Mitochondrial ribosome assembly", "Mitochondrial rna 3 end processing", "Mitochondrial rna catabolic process", "Mitochondrial rna metabolic process", "Mitochondrial rna modification", "Mitochondrial rna processing", "Mitochondrial transcription", "Mitochondrial translation", "Mitochondrial translational elongation", "Mitochondrial transmembrane transport", "Mitochondrial transport", "Mitochondrial trna processing", "Mitochondrion distribution", "Mitochondrion endoplasmic reticulum membrane tethering", "Mitochondrion localization", "Mitochondrion morphogenesis", "Mitochondrion organization", "Mitophagy", "Mitotic cell cycle", "Mitotic cell cycle checkpoint signaling", "Mitotic cell cycle phase transition", "Mitotic cell cycle process", "Mitotic chromosome condensation", "Mitotic cytokinesis", "Mitotic cytokinetic process", "Mitotic dna integrity checkpoint signaling", "Mitotic dna replication", "Mitotic dna replication checkpoint signaling", "Mitotic g1 s transition checkpoint signaling", "Mitotic g2 dna damage checkpoint signaling", "Mitotic g2 m transition checkpoint", "Mitotic intra s dna damage checkpoint signaling", "Mitotic metaphase plate congression", "Mitotic nuclear division", "Mitotic nuclear membrane disassembly", "Mitotic nuclear membrane organization", "Mitotic recombination", "Mitotic sister chromatid cohesion", "Mitotic sister chromatid segregation", "Mitotic spindle assembly", "Mitotic spindle midzone assembly", "Mitotic spindle organization", "Modification dependent macromolecule catabolic process", "Modification of postsynaptic actin cytoskeleton", "Modification of postsynaptic structure", "Modification of synaptic structure", "Modified amino acid transport", "Modulation by host of symbiont catalytic activity", "Modulation by host of symbiont process", "Modulation by host of viral genome replication", "Modulation by host of viral process", "Modulation of age related behavioral decline", "Modulation of excitatory postsynaptic potential", "Molting cycle", "Monoacylglycerol catabolic process", "Monoacylglycerol metabolic process", "Monoamine transport", "Monocarboxylic acid biosynthetic process", "Monocarboxylic acid catabolic process", "Monocarboxylic acid metabolic process", "Monocarboxylic acid transport", "Monocyte chemotaxis", "Monocyte differentiation", "Monocyte extravasation", "Mononuclear cell differentiation", "Mononuclear cell migration", "Monosaccharide biosynthetic process", "Monosaccharide catabolic process", "Monosaccharide metabolic process", "Monoubiquitinated protein deubiquitination", "Monovalent inorganic anion homeostasis", "Monovalent inorganic cation homeostasis", "Morphogenesis of a branching structure", "Morphogenesis of a polarized epithelium", "Morphogenesis of an endothelium", "Morphogenesis of an epithelial bud", "Morphogenesis of an epithelial fold", "Morphogenesis of an epithelial sheet", "Morphogenesis of an epithelium", "Morphogenesis of embryonic epithelium", "Motor behavior", "Motor learning", "Motor neuron apoptotic process", "Motor neuron axon guidance", "Mrna 3 end processing", "Mrna 3 end processing by stem loop binding and cleavage", "Mrna 3 splice site recognition", "Mrna 5 splice site recognition", "Mrna alternative polyadenylation", "Mrna catabolic process", "Mrna cis splicing via spliceosome", "Mrna cleavage", "Mrna cleavage involved in mrna processing", "Mrna destabilization mediated gene silencing", "Mrna export from nucleus", "Mrna metabolic process", "Mrna methylation", "Mrna modification", "Mrna processing", "Mrna pseudouridine synthesis", "Mrna splice site selection", "Mrna transcription", "Mrna transport", "Mucopolysaccharide metabolic process", "Multi multicellular organism process", "Multi organism reproductive process", "Multicellular organism aging", "Multicellular organism growth", "Multicellular organism reproduction", "Multicellular organismal homeostasis", "Multicellular organismal movement", "Multicellular organismal response to stress", "Multicellular organismal signaling", "Multivesicular body organization", "Multivesicular body sorting pathway", "Muscle adaptation", "Muscle cell apoptotic process", "Muscle cell cellular homeostasis", "Muscle cell development", "Muscle cell differentiation", "Muscle cell migration", "Muscle cell proliferation", "Muscle contraction", "Muscle hypertrophy", "Muscle hypertrophy in response to stress", "Muscle organ development", "Muscle organ morphogenesis", "Muscle structure development", "Muscle system process", "Muscle tissue development", "Myd88 dependent toll like receptor signaling pathway", "Myd88 independent toll like receptor signaling pathway", "Myelin assembly", "Myelin maintenance", "Myeloid cell activation involved in immune response", "Myeloid cell apoptotic process", "Myeloid cell development", "Myeloid cell differentiation", "Myeloid cell homeostasis", "Myeloid dendritic cell activation", "Myeloid dendritic cell cytokine production", "Myeloid leukocyte activation", "Myeloid leukocyte cytokine production", "Myeloid leukocyte differentiation", "Myeloid leukocyte mediated immunity", "Myeloid leukocyte migration", "Myoblast differentiation", "Myoblast fusion", "Myoblast migration", "Myofibroblast differentiation", "Myotube cell development", "Myotube differentiation", "N acetylglucosamine metabolic process", "N acetylneuraminate catabolic process", "N acetylneuraminate metabolic process", "N acylethanolamine metabolic process", "N glycan processing", "N terminal peptidyl methionine acetylation", "N terminal protein amino acid acetylation", "N terminal protein amino acid modification", "N terminal protein lipidation", "Nad biosynthesis via nicotinamide riboside salvage pathway", "Nad metabolic process", "Nadh dehydrogenase complex assembly", "Nadh metabolic process", "Nadh oxidation", "Nadh regeneration", "Nadp metabolic process", "Nadph regeneration", "Natural killer cell activation", "Natural killer cell activation involved in immune response", "Natural killer cell degranulation", "Natural killer cell differentiation", "Natural killer cell mediated immunity", "Ncrna 3 end processing", "Ncrna catabolic process", "Ncrna export from nucleus", "Ncrna metabolic process", "Ncrna processing", "Ncrna transcription", "Necroptotic signaling pathway", "Necrotic cell death", "Negative chemotaxis", "Negative regulation by host of viral genome replication", "Negative regulation by host of viral process", "Negative regulation by host of viral transcription", "Negative regulation of actin filament bundle assembly", "Negative regulation of actin filament depolymerization", "Negative regulation of actin filament polymerization", "Negative regulation of actin nucleation", "Negative regulation of activated t cell proliferation", "Negative regulation of activin receptor signaling pathway", "Negative regulation of adaptive immune response", "Negative regulation of adenylate cyclase activating adrenergic receptor signaling pathway", "Negative regulation of adenylate cyclase activating g protein coupled receptor signaling pathway", "Negative regulation of adenylate cyclase activity", "Negative regulation of alcohol biosynthetic process", "Negative regulation of alpha beta t cell activation", "Negative regulation of alpha beta t cell differentiation", "Negative regulation of alpha beta t cell proliferation", "Negative regulation of amine transport", "Negative regulation of amino acid transport", "Negative regulation of amyloid beta clearance", "Negative regulation of amyloid fibril formation", "Negative regulation of amyloid precursor protein biosynthetic process", "Negative regulation of amyloid precursor protein catabolic process", "Negative regulation of androgen receptor signaling pathway", "Negative regulation of anion transmembrane transport", "Negative regulation of anion transport", "Negative regulation of anoikis", "Negative regulation of antigen receptor mediated signaling pathway", "Negative regulation of apoptotic signaling pathway", "Negative regulation of arp2 3 complex mediated actin nucleation", "Negative regulation of atp biosynthetic process", "Negative regulation of atp dependent activity", "Negative regulation of atp metabolic process", "Negative regulation of autophagosome assembly", "Negative regulation of autophagosome maturation", "Negative regulation of autophagy", "Negative regulation of autophagy of mitochondrion", "Negative regulation of axon extension", "Negative regulation of axonogenesis", "Negative regulation of b cell activation", "Negative regulation of b cell apoptotic process", "Negative regulation of b cell differentiation", "Negative regulation of b cell mediated immunity", "Negative regulation of b cell proliferation", "Negative regulation of bicellular tight junction assembly", "Negative regulation of binding", "Negative regulation of biomineralization", "Negative regulation of biosynthetic process", "Negative regulation of blood circulation", "Negative regulation of blood pressure", "Negative regulation of blood vessel endothelial cell migration", "Negative regulation of bmp signaling pathway", "Negative regulation of bone remodeling", "Negative regulation of calcineurin mediated signaling", "Negative regulation of calcium ion dependent exocytosis", "Negative regulation of calcium ion import", "Negative regulation of calcium ion transmembrane transport", "Negative regulation of calcium ion transport", "Negative regulation of calcium ion transport into cytosol", "Negative regulation of calcium mediated signaling", "Negative regulation of camp dependent protein kinase activity", "Negative regulation of camp mediated signaling", "Negative regulation of canonical wnt signaling pathway", "Negative regulation of carbohydrate metabolic process", "Negative regulation of cardiac muscle adaptation", "Negative regulation of cardiac muscle contraction", "Negative regulation of cardiac muscle tissue growth", "Negative regulation of cartilage development", "Negative regulation of catabolic process", "Negative regulation of catalytic activity", "Negative regulation of cation channel activity", "Negative regulation of cd4 positive alpha beta t cell activation", "Negative regulation of cd4 positive alpha beta t cell differentiation", "Negative regulation of cell activation", "Negative regulation of cell adhesion", "Negative regulation of cell adhesion mediated by integrin", "Negative regulation of cell aging", "Negative regulation of cell cell adhesion", "Negative regulation of cell cycle", "Negative regulation of cell cycle checkpoint", "Negative regulation of cell cycle g1 s phase transition", "Negative regulation of cell cycle g2 m phase transition", "Negative regulation of cell cycle phase transition", "Negative regulation of cell cycle process", "Negative regulation of cell death", "Negative regulation of cell development", "Negative regulation of cell differentiation", "Negative regulation of cell division", "Negative regulation of cell growth", "Negative regulation of cell growth involved in cardiac muscle cell development", "Negative regulation of cell junction assembly", "Negative regulation of cell killing", "Negative regulation of cell matrix adhesion", "Negative regulation of cell morphogenesis involved in differentiation", "Negative regulation of cell population proliferation", "Negative regulation of cell projection organization", "Negative regulation of cell size", "Negative regulation of cell substrate adhesion", "Negative regulation of cell substrate junction organization", "Negative regulation of cell volume", "Negative regulation of cellular amide metabolic process", "Negative regulation of cellular catabolic process", "Negative regulation of cellular component organization", "Negative regulation of cellular macromolecule biosynthetic process", "Negative regulation of cellular protein catabolic process", "Negative regulation of cellular respiration", "Negative regulation of cellular response to growth factor stimulus", "Negative regulation of cellular response to hypoxia", "Negative regulation of cellular response to insulin stimulus", "Negative regulation of cellular senescence", "Negative regulation of centriole replication", "Negative regulation of centrosome duplication", "Negative regulation of chemokine mediated signaling pathway", "Negative regulation of chemotaxis", "Negative regulation of cholesterol metabolic process", "Negative regulation of chondrocyte differentiation", "Negative regulation of chromatin binding", "Negative regulation of chromosome organization", "Negative regulation of cilium assembly", "Negative regulation of circadian rhythm", "Negative regulation of cold induced thermogenesis", "Negative regulation of collateral sprouting", "Negative regulation of cyclic nucleotide phosphodiesterase activity", "Negative regulation of cyclin dependent protein serine threonine kinase activity", "Negative regulation of cysteine type endopeptidase activity", "Negative regulation of cysteine type endopeptidase activity involved in apoptotic signaling pathway", "Negative regulation of cytokine production", "Negative regulation of cytokine production involved in immune response", "Negative regulation of cytokine production involved in inflammatory response", "Negative regulation of cytokinesis", "Negative regulation of cytoplasmic translation", "Negative regulation of cytoskeleton organization", "Negative regulation of cytosolic calcium ion concentration", "Negative regulation of defense response", "Negative regulation of defense response to virus", "Negative regulation of dendrite development", "Negative regulation of dendrite morphogenesis", "Negative regulation of dendritic spine development", "Negative regulation of dendritic spine morphogenesis", "Negative regulation of dephosphorylation", "Negative regulation of developmental growth", "Negative regulation of developmental process", "Negative regulation of dna binding", "Negative regulation of dna binding transcription factor activity", "Negative regulation of dna biosynthetic process", "Negative regulation of dna damage checkpoint", "Negative regulation of dna damage response signal transduction by p53 class mediator", "Negative regulation of dna dependent dna replication", "Negative regulation of dna metabolic process", "Negative regulation of dna recombination", "Negative regulation of dna repair", "Negative regulation of dna replication", "Negative regulation of dna templated transcription elongation", "Negative regulation of dna templated transcription initiation", "Negative regulation of double strand break repair via homologous recombination", "Negative regulation of double strand break repair via nonhomologous end joining", "Negative regulation of endocytosis", "Negative regulation of endoplasmic reticulum calcium ion concentration", "Negative regulation of endoplasmic reticulum stress induced eif2 alpha phosphorylation", "Negative regulation of endoplasmic reticulum stress induced intrinsic apoptotic signaling pathway", "Negative regulation of endoplasmic reticulum unfolded protein response", "Negative regulation of endothelial cell proliferation", "Negative regulation of epidermal growth factor activated receptor activity", "Negative regulation of epidermis development", "Negative regulation of epithelial cell apoptotic process", "Negative regulation of epithelial cell differentiation", "Negative regulation of epithelial cell migration", "Negative regulation of epithelial cell proliferation", "Negative regulation of erad pathway", "Negative regulation of erbb signaling pathway", "Negative regulation of erk1 and erk2 cascade", "Negative regulation of erythrocyte differentiation", "Negative regulation of establishment of protein localization", "Negative regulation of establishment of protein localization to mitochondrion", "Negative regulation of excitatory postsynaptic potential", "Negative regulation of execution phase of apoptosis", "Negative regulation of exocytosis", "Negative regulation of extrinsic apoptotic signaling pathway", "Negative regulation of extrinsic apoptotic signaling pathway via death domain receptors", "Negative regulation of fat cell differentiation", "Negative regulation of fatty acid beta oxidation", "Negative regulation of fatty acid biosynthetic process", "Negative regulation of fatty acid metabolic process", "Negative regulation of fatty acid oxidation", "Negative regulation of fatty acid transport", "Negative regulation of fibroblast apoptotic process", "Negative regulation of fibroblast migration", "Negative regulation of fibroblast proliferation", "Negative regulation of filopodium assembly", "Negative regulation of g protein coupled receptor signaling pathway", "Negative regulation of gene expression", "Negative regulation of gene expression epigenetic", "Negative regulation of glial cell apoptotic process", "Negative regulation of glial cell differentiation", "Negative regulation of glial cell proliferation", "Negative regulation of gliogenesis", "Negative regulation of glucocorticoid metabolic process", "Negative regulation of gluconeogenesis", "Negative regulation of glucose import", "Negative regulation of glucose transmembrane transport", "Negative regulation of glycolytic process", "Negative regulation of glycoprotein metabolic process", "Negative regulation of golgi to plasma membrane protein transport", "Negative regulation of granulocyte chemotaxis", "Negative regulation of growth", "Negative regulation of gtpase activity", "Negative regulation of guanyl nucleotide exchange factor activity", "Negative regulation of heart rate", "Negative regulation of helicase activity", "Negative regulation of hematopoietic progenitor cell differentiation", "Negative regulation of hemopoiesis", "Negative regulation of high voltage gated calcium channel activity", "Negative regulation of hippo signaling", "Negative regulation of histone acetylation", "Negative regulation of histone deacetylation", "Negative regulation of histone h3 k27 methylation", "Negative regulation of histone h3 k4 methylation", "Negative regulation of histone h3 k9 methylation", "Negative regulation of histone h3 k9 trimethylation", "Negative regulation of histone h4 acetylation", "Negative regulation of histone methylation", "Negative regulation of histone modification", "Negative regulation of histone phosphorylation", "Negative regulation of homotypic cell cell adhesion", "Negative regulation of hormone biosynthetic process", "Negative regulation of hormone metabolic process", "Negative regulation of hormone secretion", "Negative regulation of hydrogen peroxide mediated programmed cell death", "Negative regulation of hydrolase activity", "Negative regulation of hypoxia induced intrinsic apoptotic signaling pathway", "Negative regulation of i kappab kinase nf kappab signaling", "Negative regulation of immune effector process", "Negative regulation of immune response", "Negative regulation of immune system process", "Negative regulation of immunoglobulin production", "Negative regulation of inclusion body assembly", "Negative regulation of inflammatory response", "Negative regulation of inflammatory response to antigenic stimulus", "Negative regulation of innate immune response", "Negative regulation of insulin secretion involved in cellular response to glucose stimulus", "Negative regulation of interferon beta production", "Negative regulation of interferon gamma production", "Negative regulation of interleukin 1 mediated signaling pathway", "Negative regulation of interleukin 12 production", "Negative regulation of interleukin 2 production", "Negative regulation of interleukin 6 production", "Negative regulation of interleukin 8 production", "Negative regulation of intracellular estrogen receptor signaling pathway", "Negative regulation of intracellular protein transport", "Negative regulation of intracellular signal transduction", "Negative regulation of intracellular steroid hormone receptor signaling pathway", "Negative regulation of intracellular transport", "Negative regulation of intrinsic apoptotic signaling pathway", "Negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator", "Negative regulation of intrinsic apoptotic signaling pathway in response to dna damage", "Negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress", "Negative regulation of ion transmembrane transport", "Negative regulation of ion transmembrane transporter activity", "Negative regulation of ion transport", "Negative regulation of ire1 mediated unfolded protein response", "Negative regulation of isotype switching", "Negative regulation of jnk cascade", "Negative regulation of jun kinase activity", "Negative regulation of keratinocyte differentiation", "Negative regulation of keratinocyte proliferation", "Negative regulation of kidney development", "Negative regulation of kinase activity", "Negative regulation of lamellipodium assembly", "Negative regulation of lamellipodium organization", "Negative regulation of leukocyte apoptotic process", "Negative regulation of leukocyte cell cell adhesion", "Negative regulation of leukocyte chemotaxis", "Negative regulation of leukocyte degranulation", "Negative regulation of leukocyte mediated immunity", "Negative regulation of leukocyte migration", "Negative regulation of leukocyte proliferation", "Negative regulation of lipase activity", "Negative regulation of lipid biosynthetic process", "Negative regulation of lipid catabolic process", "Negative regulation of lipid kinase activity", "Negative regulation of lipid localization", "Negative regulation of lipid metabolic process", "Negative regulation of lipid storage", "Negative regulation of lipid transport", "Negative regulation of lipopolysaccharide mediated signaling pathway", "Negative regulation of lipoprotein particle clearance", "Negative regulation of locomotion", "Negative regulation of long term synaptic potentiation", "Negative regulation of low density lipoprotein particle clearance", "Negative regulation of low density lipoprotein receptor activity", "Negative regulation of lyase activity", "Negative regulation of lymphocyte activation", "Negative regulation of lymphocyte apoptotic process", "Negative regulation of lymphocyte differentiation", "Negative regulation of lymphocyte mediated immunity", "Negative regulation of lymphocyte migration", "Negative regulation of macroautophagy", "Negative regulation of macrophage chemotaxis", "Negative regulation of macrophage migration", "Negative regulation of map kinase activity", "Negative regulation of mapk cascade", "Negative regulation of mast cell activation", "Negative regulation of mast cell activation involved in immune response", "Negative regulation of mast cell degranulation", "Negative regulation of megakaryocyte differentiation", "Negative regulation of meiotic cell cycle", "Negative regulation of meiotic nuclear division", "Negative regulation of membrane permeability", "Negative regulation of membrane potential", "Negative regulation of membrane protein ectodomain proteolysis", "Negative regulation of mesenchymal cell proliferation", "Negative regulation of metalloendopeptidase activity", "Negative regulation of metallopeptidase activity", "Negative regulation of metaphase anaphase transition of cell cycle", "Negative regulation of mhc class ii biosynthetic process", "Negative regulation of microtubule polymerization", "Negative regulation of microtubule polymerization or depolymerization", "Negative regulation of mirna transcription", "Negative regulation of mitochondrial fusion", "Negative regulation of mitochondrial membrane permeability", "Negative regulation of mitochondrial membrane permeability involved in apoptotic process", "Negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway", "Negative regulation of mitochondrion organization", "Negative regulation of mitophagy", "Negative regulation of mitotic cell cycle", "Negative regulation of mitotic cell cycle phase transition", "Negative regulation of molecular function", "Negative regulation of monocyte chemotaxis", "Negative regulation of monocyte differentiation", "Negative regulation of mononuclear cell migration", "Negative regulation of monooxygenase activity", "Negative regulation of mrna 3 end processing", "Negative regulation of mrna catabolic process", "Negative regulation of mrna metabolic process", "Negative regulation of mrna processing", "Negative regulation of mrna splicing via spliceosome", "Negative regulation of multicellular organism growth", "Negative regulation of multicellular organismal process", "Negative regulation of muscle adaptation", "Negative regulation of muscle cell apoptotic process", "Negative regulation of muscle cell differentiation", "Negative regulation of muscle contraction", "Negative regulation of muscle hypertrophy", "Negative regulation of muscle organ development", "Negative regulation of muscle tissue development", "Negative regulation of myelination", "Negative regulation of myeloid cell apoptotic process", "Negative regulation of myeloid cell differentiation", "Negative regulation of myeloid leukocyte differentiation", "Negative regulation of myeloid leukocyte mediated immunity", "Negative regulation of myoblast differentiation", "Negative regulation of myosin light chain phosphatase activity", "Negative regulation of myotube differentiation", "Negative regulation of natural killer cell activation", "Negative regulation of natural killer cell mediated immunity", "Negative regulation of necrotic cell death", "Negative regulation of nervous system development", "Negative regulation of nervous system process", "Negative regulation of neural precursor cell proliferation", "Negative regulation of neuroblast proliferation", "Negative regulation of neuron apoptotic process", "Negative regulation of neuron death", "Negative regulation of neuron differentiation", "Negative regulation of neuron migration", "Negative regulation of neuron projection development", "Negative regulation of neuron projection regeneration", "Negative regulation of neurotransmitter secretion", "Negative regulation of neurotransmitter transport", "Negative regulation of neutrophil migration", "Negative regulation of nf kappab transcription factor activity", "Negative regulation of nik nf kappab signaling", "Negative regulation of nitric oxide metabolic process", "Negative regulation of nitric oxide synthase activity", "Negative regulation of notch signaling pathway", "Negative regulation of nuclear division", "Negative regulation of nuclear transcribed mrna catabolic process deadenylation dependent decay", "Negative regulation of nuclear transcribed mrna catabolic process nonsense mediated decay", "Negative regulation of nuclease activity", "Negative regulation of nucleobase containing compound metabolic process", "Negative regulation of nucleocytoplasmic transport", "Negative regulation of nucleotide biosynthetic process", "Negative regulation of nucleotide metabolic process", "Negative regulation of oligodendrocyte differentiation", "Negative regulation of organ growth", "Negative regulation of organelle assembly", "Negative regulation of organelle organization", "Negative regulation of organic acid transport", "Negative regulation of osteoblast differentiation", "Negative regulation of osteoblast proliferation", "Negative regulation of osteoclast differentiation", "Negative regulation of oxidative phosphorylation", "Negative regulation of oxidative stress induced cell death", "Negative regulation of oxidative stress induced intrinsic apoptotic signaling pathway", "Negative regulation of oxidative stress induced neuron death", "Negative regulation of oxidative stress induced neuron intrinsic apoptotic signaling pathway", "Negative regulation of oxidoreductase activity", "Negative regulation of p38mapk cascade", "Negative regulation of pathway restricted smad protein phosphorylation", "Negative regulation of peptidase activity", "Negative regulation of peptide secretion", "Negative regulation of peptidyl lysine acetylation", "Negative regulation of peptidyl serine phosphorylation", "Negative regulation of peptidyl threonine phosphorylation", "Negative regulation of peptidyl tyrosine phosphorylation", "Negative regulation of perk mediated unfolded protein response", "Negative regulation of phagocytosis", "Negative regulation of phosphatase activity", "Negative regulation of phosphatidylinositol 3 kinase signaling", "Negative regulation of phospholipase activity", "Negative regulation of phospholipid metabolic process", "Negative regulation of phosphoprotein phosphatase activity", "Negative regulation of phosphorus metabolic process", "Negative regulation of phosphorylation", "Negative regulation of plasma membrane bounded cell projection assembly", "Negative regulation of platelet derived growth factor receptor signaling pathway", "Negative regulation of posttranscriptional gene silencing", "Negative regulation of potassium ion transmembrane transport", "Negative regulation of potassium ion transport", "Negative regulation of production of mirnas involved in gene silencing by mirna", "Negative regulation of production of molecular mediator of immune response", "Negative regulation of programmed necrotic cell death", "Negative regulation of prostaglandin biosynthetic process", "Negative regulation of proteasomal protein catabolic process", "Negative regulation of proteasomal ubiquitin dependent protein catabolic process", "Negative regulation of protein acetylation", "Negative regulation of protein autophosphorylation", "Negative regulation of protein binding", "Negative regulation of protein catabolic process", "Negative regulation of protein containing complex assembly", "Negative regulation of protein containing complex disassembly", "Negative regulation of protein dephosphorylation", "Negative regulation of protein exit from endoplasmic reticulum", "Negative regulation of protein export from nucleus", "Negative regulation of protein import into nucleus", "Negative regulation of protein k63 linked ubiquitination", "Negative regulation of protein kinase activity by regulation of protein phosphorylation", "Negative regulation of protein kinase b signaling", "Negative regulation of protein localization", "Negative regulation of protein localization to cell periphery", "Negative regulation of protein localization to cell surface", "Negative regulation of protein localization to membrane", "Negative regulation of protein localization to nucleus", "Negative regulation of protein maturation", "Negative regulation of protein metabolic process", "Negative regulation of protein modification by small protein conjugation or removal", "Negative regulation of protein modification process", "Negative regulation of protein polymerization", "Negative regulation of protein polyubiquitination", "Negative regulation of protein secretion", "Negative regulation of protein serine threonine kinase activity", "Negative regulation of protein sumoylation", "Negative regulation of protein targeting to membrane", "Negative regulation of protein targeting to mitochondrion", "Negative regulation of protein tyrosine kinase activity", "Negative regulation of proteolysis", "Negative regulation of proteolysis involved in cellular protein catabolic process", "Negative regulation of reactive oxygen species biosynthetic process", "Negative regulation of reactive oxygen species metabolic process", "Negative regulation of receptor binding", "Negative regulation of receptor internalization", "Negative regulation of receptor mediated endocytosis", "Negative regulation of receptor signaling pathway via jak stat", "Negative regulation of receptor signaling pathway via stat", "Negative regulation of regulated secretory pathway", "Negative regulation of release of cytochrome c from mitochondria", "Negative regulation of reproductive process", "Negative regulation of respiratory burst", "Negative regulation of respiratory burst involved in inflammatory response", "Negative regulation of response to biotic stimulus", "Negative regulation of response to cytokine stimulus", "Negative regulation of response to dna damage stimulus", "Negative regulation of response to endoplasmic reticulum stress", "Negative regulation of response to external stimulus", "Negative regulation of response to food", "Negative regulation of response to oxidative stress", "Negative regulation of response to reactive oxygen species", "Negative regulation of response to stimulus", "Negative regulation of response to wounding", "Negative regulation of retinoic acid receptor signaling pathway", "Negative regulation of rho protein signal transduction", "Negative regulation of rig i signaling pathway", "Negative regulation of rna catabolic process", "Negative regulation of rna splicing", "Negative regulation of ruffle assembly", "Negative regulation of ryanodine sensitive calcium release channel activity", "Negative regulation of schwann cell proliferation", "Negative regulation of secondary metabolite biosynthetic process", "Negative regulation of secretion", "Negative regulation of sequestering of triglyceride", "Negative regulation of signal transduction by p53 class mediator", "Negative regulation of signal transduction in absence of ligand", "Negative regulation of signaling", "Negative regulation of signaling receptor activity", "Negative regulation of single stranded viral rna replication via double stranded dna intermediate", "Negative regulation of sister chromatid cohesion", "Negative regulation of smad protein signal transduction", "Negative regulation of small gtpase mediated signal transduction", "Negative regulation of small molecule metabolic process", "Negative regulation of smooth muscle cell apoptotic process", "Negative regulation of smooth muscle cell differentiation", "Negative regulation of smooth muscle cell migration", "Negative regulation of smooth muscle cell proliferation", "Negative regulation of smoothened signaling pathway", "Negative regulation of smoothened signaling pathway involved in dorsal ventral neural tube patterning", "Negative regulation of sodium ion transmembrane transport", "Negative regulation of sodium ion transport", "Negative regulation of sprouting angiogenesis", "Negative regulation of stem cell differentiation", "Negative regulation of steroid metabolic process", "Negative regulation of stress activated protein kinase signaling cascade", "Negative regulation of striated muscle cell apoptotic process", "Negative regulation of striated muscle cell differentiation", "Negative regulation of striated muscle contraction", "Negative regulation of supramolecular fiber organization", "Negative regulation of synapse assembly", "Negative regulation of synapse organization", "Negative regulation of synaptic transmission", "Negative regulation of synaptic transmission glutamatergic", "Negative regulation of synaptic vesicle exocytosis", "Negative regulation of systemic arterial blood pressure", "Negative regulation of t cell apoptotic process", "Negative regulation of t cell differentiation", "Negative regulation of t cell proliferation", "Negative regulation of t cell receptor signaling pathway", "Negative regulation of t helper cell differentiation", "Negative regulation of telomerase activity", "Negative regulation of telomere capping", "Negative regulation of telomere maintenance", "Negative regulation of telomere maintenance via telomerase", "Negative regulation of telomere maintenance via telomere lengthening", "Negative regulation of tissue remodeling", "Negative regulation of toll like receptor signaling pathway", "Negative regulation of tor signaling", "Negative regulation of transcription by competitive promoter binding", "Negative regulation of transcription by rna polymerase i", "Negative regulation of transcription by rna polymerase ii", "Negative regulation of transcription from rna polymerase ii promoter in response to stress", "Negative regulation of transcription initiation from rna polymerase ii promoter", "Negative regulation of transcription regulatory region dna binding", "Negative regulation of transferase activity", "Negative regulation of transforming growth factor beta production", "Negative regulation of transforming growth factor beta receptor signaling pathway", "Negative regulation of transforming growth factor beta1 production", "Negative regulation of translational elongation", "Negative regulation of translational initiation", "Negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway", "Negative regulation of transmembrane transport", "Negative regulation of transport", "Negative regulation of transporter activity", "Negative regulation of trophoblast cell migration", "Negative regulation of tubulin deacetylation", "Negative regulation of tumor necrosis factor superfamily cytokine production", "Negative regulation of type 2 immune response", "Negative regulation of type b pancreatic cell apoptotic process", "Negative regulation of type i interferon mediated signaling pathway", "Negative regulation of type i interferon production", "Negative regulation of tyrosine phosphorylation of stat protein", "Negative regulation of ubiquitin dependent protein catabolic process", "Negative regulation of ubiquitin protein ligase activity", "Negative regulation of ubiquitin protein transferase activity", "Negative regulation of vascular associated smooth muscle cell apoptotic process", "Negative regulation of vascular associated smooth muscle cell differentiation", "Negative regulation of vascular associated smooth muscle cell migration", "Negative regulation of vascular associated smooth muscle cell proliferation", "Negative regulation of vascular endothelial growth factor production", "Negative regulation of vascular endothelial growth factor receptor signaling pathway", "Negative regulation of vascular permeability", "Negative regulation of vasculature development", "Negative regulation of viral entry into host cell", "Negative regulation of viral genome replication", "Negative regulation of viral induced cytoplasmic pattern recognition receptor signaling pathway", "Negative regulation of viral life cycle", "Negative regulation of viral process", "Negative regulation of viral transcription", "Negative regulation of vitamin metabolic process", "Negative regulation of voltage gated calcium channel activity", "Negative regulation of wnt signaling pathway", "Negative regulation of wound healing", "Nephric duct development", "Nephric duct morphogenesis", "Nephron development", "Nephron epithelium development", "Nephron morphogenesis", "Nephron tubule epithelial cell differentiation", "Nephron tubule formation", "Nerve development", "Nerve growth factor signaling pathway", "Nervous system process", "Nervous system process involved in regulation of systemic arterial blood pressure", "Netrin activated signaling pathway", "Neural crest cell differentiation", "Neural crest cell migration", "Neural crest formation", "Neural nucleus development", "Neural plate development", "Neural plate morphogenesis", "Neural precursor cell proliferation", "Neural retina development", "Neural tube development", "Neural tube formation", "Neural tube patterning", "Neuroblast division", "Neuroblast proliferation", "Neuroendocrine cell differentiation", "Neuroepithelial cell differentiation", "Neurofilament cytoskeleton organization", "Neurogenesis", "Neuroinflammatory response", "Neuromuscular junction development", "Neuromuscular process", "Neuromuscular process controlling balance", "Neuromuscular process controlling posture", "Neuromuscular synaptic transmission", "Neuron apoptotic process", "Neuron cellular homeostasis", "Neuron death", "Neuron death in response to hydrogen peroxide", "Neuron death in response to oxidative stress", "Neuron development", "Neuron differentiation", "Neuron fate commitment", "Neuron fate determination", "Neuron intrinsic apoptotic signaling pathway in response to oxidative stress", "Neuron maturation", "Neuron migration", "Neuron projection arborization", "Neuron projection extension", "Neuron projection extension involved in neuron projection guidance", "Neuron projection guidance", "Neuron projection maintenance", "Neuron projection organization", "Neuron projection regeneration", "Neuron recognition", "Neuron remodeling", "Neuronal action potential", "Neuronal ion channel clustering", "Neuronal signal transduction", "Neuronal stem cell population maintenance", "Neuropeptide signaling pathway", "Neurotransmitter biosynthetic process", "Neurotransmitter catabolic process", "Neurotransmitter gated ion channel clustering", "Neurotransmitter metabolic process", "Neurotransmitter receptor internalization", "Neurotransmitter receptor localization to postsynaptic specialization membrane", "Neurotransmitter receptor transport", "Neurotransmitter receptor transport endosome to postsynaptic membrane", "Neurotransmitter receptor transport postsynaptic endosome to lysosome", "Neurotransmitter receptor transport to plasma membrane", "Neurotransmitter reuptake", "Neurotransmitter secretion", "Neurotransmitter transport", "Neurotransmitter uptake", "Neurotrophin production", "Neurotrophin signaling pathway", "Neurotrophin trk receptor signaling pathway", "Neutral amino acid transport", "Neutral lipid biosynthetic process", "Neutral lipid catabolic process", "Neutral lipid metabolic process", "Neutrophil activation involved in immune response", "Neutrophil apoptotic process", "Neutrophil chemotaxis", "Neutrophil clearance", "Neutrophil degranulation", "Neutrophil differentiation", "Neutrophil homeostasis", "Neutrophil mediated immunity", "Neutrophil migration", "Nik nf kappab signaling", "Nitric oxide mediated signal transduction", "Nitric oxide synthase biosynthetic process", "Nitrogen compound transport", "Nk t cell activation", "Nk t cell differentiation", "Nls bearing protein import into nucleus", "Non canonical wnt signaling pathway", "Non lytic viral release", "Non membrane bounded organelle assembly", "Non motile cilium assembly", "Nonribosomal peptide biosynthetic process", "Notch receptor processing", "Notch signaling pathway", "Nuclear body organization", "Nuclear chromosome segregation", "Nuclear envelope organization", "Nuclear export", "Nuclear membrane organization", "Nuclear membrane reassembly", "Nuclear migration", "Nuclear ncrna surveillance", "Nuclear pore complex assembly", "Nuclear pore organization", "Nuclear transcribed mrna catabolic process", "Nuclear transcribed mrna catabolic process deadenylation dependent decay", "Nuclear transcribed mrna catabolic process deadenylation independent decay", "Nuclear transcribed mrna catabolic process exonucleolytic", "Nuclear transcribed mrna catabolic process exonucleolytic 3 5", "Nuclear transcribed mrna catabolic process nonsense mediated decay", "Nuclear transcribed mrna poly a tail shortening", "Nuclear transport", "Nucleic acid phosphodiester bond hydrolysis", "Nucleobase biosynthetic process", "Nucleobase catabolic process", "Nucleobase containing compound transport", "Nucleobase containing small molecule biosynthetic process", "Nucleobase containing small molecule catabolic process", "Nucleobase containing small molecule interconversion", "Nucleobase containing small molecule metabolic process", "Nucleobase metabolic process", "Nucleobase transport", "Nucleolar chromatin organization", "Nucleolar large rrna transcription by rna polymerase i", "Nucleolus organization", "Nucleoside bisphosphate biosynthetic process", "Nucleoside bisphosphate catabolic process", "Nucleoside bisphosphate metabolic process", "Nucleoside catabolic process", "Nucleoside diphosphate biosynthetic process", "Nucleoside diphosphate catabolic process", "Nucleoside diphosphate metabolic process", "Nucleoside metabolic process", "Nucleoside monophosphate biosynthetic process", "Nucleoside monophosphate catabolic process", "Nucleoside monophosphate metabolic process", "Nucleoside monophosphate phosphorylation", "Nucleoside phosphate biosynthetic process", "Nucleoside phosphate catabolic process", "Nucleoside salvage", "Nucleoside triphosphate biosynthetic process", "Nucleoside triphosphate catabolic process", "Nucleoside triphosphate metabolic process", "Nucleosome assembly", "Nucleosome mobilization", "Nucleosome organization", "Nucleosome positioning", "Nucleotide binding domain leucine rich repeat containing receptor signaling pathway", "Nucleotide binding oligomerization domain containing 2 signaling pathway", "Nucleotide excision repair", "Nucleotide excision repair dna gap filling", "Nucleotide excision repair dna incision", "Nucleotide phosphorylation", "Nucleotide salvage", "Nucleotide sugar biosynthetic process", "Nucleotide sugar metabolic process", "Nucleotide sugar transmembrane transport", "Nucleotide transmembrane transport", "Nucleotide transport", "Nucleus localization", "Nucleus organization", "O glycan processing", "Odontoblast differentiation", "Odontogenesis", "Odontogenesis of dentin containing tooth", "Olefinic compound biosynthetic process", "Olefinic compound metabolic process", "Olfactory behavior", "Olfactory bulb interneuron development", "Olfactory bulb interneuron differentiation", "Olfactory lobe development", "Oligodendrocyte development", "Oligodendrocyte differentiation", "Oligodendrocyte progenitor proliferation", "Oligopeptide transport", "Oligosaccharide biosynthetic process", "Oligosaccharide catabolic process", "Oligosaccharide lipid intermediate biosynthetic process", "Oligosaccharide metabolic process", "One carbon metabolic process", "Oocyte construction", "Oocyte differentiation", "Oocyte maturation", "Oogenesis", "Optic nerve development", "Organ growth", "Organ induction", "Organ or tissue specific immune response", "Organelle assembly", "Organelle disassembly", "Organelle fission", "Organelle fusion", "Organelle inheritance", "Organelle localization", "Organelle membrane fusion", "Organelle transport along microtubule", "Organic acid biosynthetic process", "Organic acid catabolic process", "Organic acid metabolic process", "Organic acid transmembrane transport", "Organic acid transport", "Organic anion transport", "Organic cation transport", "Organic cyclic compound catabolic process", "Organic hydroxy compound biosynthetic process", "Organic hydroxy compound catabolic process", "Organic hydroxy compound metabolic process", "Organic hydroxy compound transport", "Organism emergence from protective structure", "Organonitrogen compound biosynthetic process", "Organonitrogen compound catabolic process", "Organophosphate biosynthetic process", "Organophosphate catabolic process", "Organophosphate ester transport", "Organophosphate metabolic process", "Ornithine metabolic process", "Ornithine transport", "Ossification", "Osteoblast differentiation", "Osteoblast proliferation", "Osteoclast development", "Osteoclast differentiation", "Otic vesicle development", "Otic vesicle formation", "Otic vesicle morphogenesis", "Otolith development", "Outer dynein arm assembly", "Outer ear morphogenesis", "Outer mitochondrial membrane organization", "Outflow tract morphogenesis", "Ovarian follicle development", "Oviduct development", "Ovulation", "Ovulation cycle", "Ovulation cycle process", "Ovulation from ovarian follicle", "Oxaloacetate metabolic process", "Oxaloacetate transport", "Oxidative demethylation", "Oxidative dna demethylation", "Oxidative phosphorylation", "Oxidative rna demethylation", "Oxygen homeostasis", "P body assembly", "P38mapk cascade", "Pallium development", "Pancreas development", "Pancreatic juice secretion", "Pantothenate metabolic process", "Parallel actin filament bundle assembly", "Paranodal junction assembly", "Parathyroid gland development", "Paraxial mesoderm development", "Parkin mediated stimulation of mitophagy in response to mitochondrial depolarization", "Pathway restricted smad protein phosphorylation", "Pattern recognition receptor signaling pathway", "Pattern specification involved in kidney development", "Pattern specification process", "Penetration of zona pellucida", "Pentose catabolic process", "Pentose metabolic process", "Pentose phosphate shunt", "Pentose phosphate shunt non oxidative branch", "Peptide antigen assembly with mhc protein complex", "Peptide biosynthetic process", "Peptide catabolic process", "Peptide cross linking", "Peptide metabolic process", "Peptide transport", "Peptidyl amino acid modification", "Peptidyl arginine methylation", "Peptidyl arginine methylation to asymmetrical dimethyl arginine", "Peptidyl arginine modification", "Peptidyl arginine n methylation", "Peptidyl asparagine modification", "Peptidyl cysteine modification", "Peptidyl diphthamide biosynthetic process from peptidyl histidine", "Peptidyl glutamic acid modification", "Peptidyl glutamine methylation", "Peptidyl histidine modification", "Peptidyl lysine acetylation", "Peptidyl lysine deacetylation", "Peptidyl lysine dimethylation", "Peptidyl lysine hydroxylation", "Peptidyl lysine methylation", "Peptidyl lysine modification", "Peptidyl lysine trimethylation", "Peptidyl methionine modification", "Peptidyl proline hydroxylation", "Peptidyl proline hydroxylation to 4 hydroxy l proline", "Peptidyl proline modification", "Peptidyl serine autophosphorylation", "Peptidyl serine dephosphorylation", "Peptidyl serine modification", "Peptidyl threonine dephosphorylation", "Peptidyl threonine modification", "Peptidyl tyrosine dephosphorylation", "Peptidyl tyrosine dephosphorylation involved in inactivation of protein kinase activity", "Peptidyl tyrosine modification", "Pericyte cell differentiation", "Peripheral nervous system axon regeneration", "Peripheral nervous system development", "Peripheral nervous system myelin maintenance", "Perk mediated unfolded protein response", "Peroxisomal transport", "Peroxisome fission", "Peroxisome organization", "Peroxisome proliferator activated receptor signaling pathway", "Ph reduction", "Phagocytosis", "Phagocytosis recognition", "Phagolysosome assembly", "Phagosome acidification", "Phagosome lysosome fusion", "Phagosome maturation", "Pharyngeal system development", "Phenol containing compound biosynthetic process", "Phenol containing compound catabolic process", "Phenol containing compound metabolic process", "Phenotypic switching", "Phosphagen metabolic process", "Phosphate ion transmembrane transport", "Phosphate ion transport", "Phosphatidic acid metabolic process", "Phosphatidylcholine acyl chain remodeling", "Phosphatidylcholine biosynthetic process", "Phosphatidylcholine catabolic process", "Phosphatidylcholine metabolic process", "Phosphatidylethanolamine acyl chain remodeling", "Phosphatidylethanolamine biosynthetic process", "Phosphatidylethanolamine metabolic process", "Phosphatidylglycerol acyl chain remodeling", "Phosphatidylglycerol biosynthetic process", "Phosphatidylglycerol metabolic process", "Phosphatidylinositol 3 kinase signaling", "Phosphatidylinositol 3 phosphate biosynthetic process", "Phosphatidylinositol acyl chain remodeling", "Phosphatidylinositol biosynthetic process", "Phosphatidylinositol dephosphorylation", "Phosphatidylinositol metabolic process", "Phosphatidylinositol phosphate biosynthetic process", "Phosphatidylserine acyl chain remodeling", "Phosphatidylserine metabolic process", "Phospholipase c activating dopamine receptor signaling pathway", "Phospholipase c activating g protein coupled receptor signaling pathway", "Phospholipid biosynthetic process", "Phospholipid catabolic process", "Phospholipid dephosphorylation", "Phospholipid homeostasis", "Phospholipid metabolic process", "Phospholipid transport", "Phosphorylation", "Phosphorylation of rna polymerase ii c terminal domain", "Photoperiodism", "Photoreceptor cell development", "Photoreceptor cell differentiation", "Photoreceptor cell maintenance", "Photoreceptor cell outer segment organization", "Phototransduction", "Phototransduction visible light", "Physiological cardiac muscle hypertrophy", "Piecemeal microautophagy of the nucleus", "Pigment accumulation", "Pigment biosynthetic process", "Pigment cell differentiation", "Pigment granule localization", "Pigment granule maturation", "Pigment granule organization", "Pigment metabolic process", "Pigmentation", "Pinocytosis", "Pirna metabolic process", "Placenta blood vessel development", "Placenta development", "Planar cell polarity pathway involved in neural tube closure", "Plasma lipoprotein particle clearance", "Plasma membrane fusion", "Plasma membrane organization", "Plasma membrane phospholipid scrambling", "Plasma membrane raft assembly", "Plasma membrane raft organization", "Plasma membrane repair", "Plasma membrane to endosome transport", "Plasma membrane tubulation", "Plasminogen activation", "Platelet activating factor metabolic process", "Platelet activation", "Platelet aggregation", "Platelet derived growth factor receptor beta signaling pathway", "Platelet derived growth factor receptor signaling pathway", "Platelet morphogenesis", "Plus end directed organelle transport along microtubule", "Pml body organization", "Podosome assembly", "Pointed end actin filament capping", "Polarized epithelial cell differentiation", "Poly a plus mrna export from nucleus", "Poly n acetyllactosamine metabolic process", "Polyadenylation dependent rna catabolic process", "Polyadenylation dependent snorna 3 end processing", "Polyamine biosynthetic process", "Polyamine metabolic process", "Polyketide metabolic process", "Polyol biosynthetic process", "Polyol catabolic process", "Polyol metabolic process", "Polyprenol metabolic process", "Polysaccharide biosynthetic process", "Polysaccharide catabolic process", "Polysaccharide metabolic process", "Pons development", "Pore complex assembly", "Porphyrin containing compound metabolic process", "Positive chemotaxis", "Positive regulation by host of viral genome replication", "Positive regulation by host of viral process", "Positive regulation by host of viral transcription", "Positive regulation by symbiont of entry into host", "Positive regulation of 3 utr mediated mrna stabilization", "Positive regulation of actin cytoskeleton reorganization", "Positive regulation of actin filament bundle assembly", "Positive regulation of actin filament depolymerization", "Positive regulation of actin filament polymerization", "Positive regulation of actin nucleation", "Positive regulation of action potential", "Positive regulation of activated t cell proliferation", "Positive regulation of activin receptor signaling pathway", "Positive regulation of acute inflammatory response", "Positive regulation of acute inflammatory response to antigenic stimulus", "Positive regulation of adaptive immune response", "Positive regulation of adenylate cyclase activity", "Positive regulation of adipose tissue development", "Positive regulation of alcohol biosynthetic process", "Positive regulation of alpha beta t cell activation", "Positive regulation of alpha beta t cell differentiation", "Positive regulation of alpha beta t cell proliferation", "Positive regulation of amine transport", "Positive regulation of amino acid transport", "Positive regulation of amyloid beta clearance", "Positive regulation of amyloid beta formation", "Positive regulation of amyloid precursor protein biosynthetic process", "Positive regulation of amyloid precursor protein catabolic process", "Positive regulation of animal organ morphogenesis", "Positive regulation of anion transmembrane transport", "Positive regulation of anion transport", "Positive regulation of anoikis", "Positive regulation of antigen receptor mediated signaling pathway", "Positive regulation of apoptotic signaling pathway", "Positive regulation of arp2 3 complex mediated actin nucleation", "Positive regulation of aspartic type peptidase activity", "Positive regulation of astrocyte differentiation", "Positive regulation of atp biosynthetic process", "Positive regulation of atp dependent activity", "Positive regulation of atp metabolic process", "Positive regulation of atpase coupled calcium transmembrane transporter activity", "Positive regulation of attachment of spindle microtubules to kinetochore", "Positive regulation of autophagy", "Positive regulation of autophagy of mitochondrion", "Positive regulation of axon extension", "Positive regulation of axonogenesis", "Positive regulation of b cell activation", "Positive regulation of b cell differentiation", "Positive regulation of b cell mediated immunity", "Positive regulation of b cell proliferation", "Positive regulation of b cell receptor signaling pathway", "Positive regulation of basement membrane assembly involved in embryonic body morphogenesis", "Positive regulation of behavior", "Positive regulation of binding", "Positive regulation of biomineralization", "Positive regulation of blood brain barrier permeability", "Positive regulation of blood circulation", "Positive regulation of blood pressure", "Positive regulation of blood pressure by epinephrine norepinephrine", "Positive regulation of blood vessel endothelial cell migration", "Positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis", "Positive regulation of bmp signaling pathway", "Positive regulation of bone mineralization", "Positive regulation of bone resorption", "Positive regulation of brown fat cell differentiation", "Positive regulation of calcineurin mediated signaling", "Positive regulation of calcium ion dependent exocytosis", "Positive regulation of calcium ion import", "Positive regulation of calcium ion transmembrane transport", "Positive regulation of calcium ion transmembrane transporter activity", "Positive regulation of calcium ion transport", "Positive regulation of calcium ion transport into cytosol", "Positive regulation of calcium mediated signaling", "Positive regulation of camp dependent protein kinase activity", "Positive regulation of camp mediated signaling", "Positive regulation of canonical wnt signaling pathway", "Positive regulation of carbohydrate metabolic process", "Positive regulation of cardiac muscle adaptation", "Positive regulation of cardiac muscle cell proliferation", "Positive regulation of cardioblast differentiation", "Positive regulation of cardiocyte differentiation", "Positive regulation of cartilage development", "Positive regulation of catabolic process", "Positive regulation of catalytic activity", "Positive regulation of catecholamine metabolic process", "Positive regulation of cation channel activity", "Positive regulation of cd4 positive alpha beta t cell activation", "Positive regulation of cd4 positive alpha beta t cell differentiation", "Positive regulation of cd8 positive alpha beta t cell activation", "Positive regulation of cell activation", "Positive regulation of cell adhesion", "Positive regulation of cell adhesion mediated by integrin", "Positive regulation of cell adhesion molecule production", "Positive regulation of cell aging", "Positive regulation of cell cell adhesion", "Positive regulation of cell cell adhesion mediated by cadherin", "Positive regulation of cell cell adhesion mediated by integrin", "Positive regulation of cell cycle", "Positive regulation of cell cycle checkpoint", "Positive regulation of cell cycle g1 s phase transition", "Positive regulation of cell cycle g2 m phase transition", "Positive regulation of cell cycle phase transition", "Positive regulation of cell cycle process", "Positive regulation of cell death", "Positive regulation of cell development", "Positive regulation of cell differentiation", "Positive regulation of cell division", "Positive regulation of cell growth", "Positive regulation of cell junction assembly", "Positive regulation of cell killing", "Positive regulation of cell matrix adhesion", "Positive regulation of cell maturation", "Positive regulation of cell migration by vascular endothelial growth factor signaling pathway", "Positive regulation of cell migration involved in sprouting angiogenesis", "Positive regulation of cell morphogenesis involved in differentiation", "Positive regulation of cell population proliferation", "Positive regulation of cell projection organization", "Positive regulation of cell size", "Positive regulation of cell substrate adhesion", "Positive regulation of cell substrate junction organization", "Positive regulation of cellular amide metabolic process", "Positive regulation of cellular amine metabolic process", "Positive regulation of cellular biosynthetic process", "Positive regulation of cellular carbohydrate metabolic process", "Positive regulation of cellular component biogenesis", "Positive regulation of cellular component organization", "Positive regulation of cellular extravasation", "Positive regulation of cellular ph reduction", "Positive regulation of cellular protein catabolic process", "Positive regulation of cellular respiration", "Positive regulation of cellular response to insulin stimulus", "Positive regulation of cellular response to transforming growth factor beta stimulus", "Positive regulation of centriole elongation", "Positive regulation of centriole replication", "Positive regulation of chemokine c c motif ligand 5 production", "Positive regulation of chemokine c x c motif ligand 2 production", "Positive regulation of chemokine production", "Positive regulation of chemotaxis", "Positive regulation of cholesterol biosynthetic process", "Positive regulation of cholesterol efflux", "Positive regulation of cholesterol metabolic process", "Positive regulation of cholesterol storage", "Positive regulation of chondrocyte differentiation", "Positive regulation of chromatin binding", "Positive regulation of chromatin organization", "Positive regulation of chromosome condensation", "Positive regulation of chromosome organization", "Positive regulation of chromosome segregation", "Positive regulation of chromosome separation", "Positive regulation of cilium assembly", "Positive regulation of circadian rhythm", "Positive regulation of clathrin dependent endocytosis", "Positive regulation of coagulation", "Positive regulation of cold induced thermogenesis", "Positive regulation of collagen metabolic process", "Positive regulation of collateral sprouting", "Positive regulation of complement activation", "Positive regulation of connective tissue replacement", "Positive regulation of corticosteroid hormone secretion", "Positive regulation of cyclase activity", "Positive regulation of cyclic nucleotide phosphodiesterase activity", "Positive regulation of cyclin dependent protein kinase activity", "Positive regulation of cysteine type endopeptidase activity", "Positive regulation of cysteine type endopeptidase activity involved in apoptotic signaling pathway", "Positive regulation of cytokine production", "Positive regulation of cytokine production involved in immune response", "Positive regulation of cytokine production involved in inflammatory response", "Positive regulation of cytokinesis", "Positive regulation of cytoplasmic translation", "Positive regulation of cytoplasmic transport", "Positive regulation of cytoskeleton organization", "Positive regulation of deacetylase activity", "Positive regulation of defense response", "Positive regulation of defense response to virus by host", "Positive regulation of dendrite development", "Positive regulation of dendrite morphogenesis", "Positive regulation of dendritic cell cytokine production", "Positive regulation of dendritic cell differentiation", "Positive regulation of dendritic spine development", "Positive regulation of dendritic spine morphogenesis", "Positive regulation of deoxyribonuclease activity", "Positive regulation of dephosphorylation", "Positive regulation of developmental growth", "Positive regulation of developmental process", "Positive regulation of digestive system process", "Positive regulation of dna binding", "Positive regulation of dna binding transcription factor activity", "Positive regulation of dna biosynthetic process", "Positive regulation of dna damage response signal transduction by p53 class mediator", "Positive regulation of dna demethylation", "Positive regulation of dna dependent dna replication", "Positive regulation of dna ligation", "Positive regulation of dna metabolic process", "Positive regulation of dna methylation dependent heterochromatin assembly", "Positive regulation of dna recombination", "Positive regulation of dna repair", "Positive regulation of dna replication", "Positive regulation of dna templated transcription elongation", "Positive regulation of dna templated transcription initiation", "Positive regulation of dopamine receptor signaling pathway", "Positive regulation of double strand break repair", "Positive regulation of double strand break repair via homologous recombination", "Positive regulation of double strand break repair via nonhomologous end joining", "Positive regulation of early endosome to late endosome transport", "Positive regulation of embryonic development", "Positive regulation of endocytic recycling", "Positive regulation of endocytosis", "Positive regulation of endoplasmic reticulum stress induced intrinsic apoptotic signaling pathway", "Positive regulation of endoplasmic reticulum unfolded protein response", "Positive regulation of endothelial cell apoptotic process", "Positive regulation of endothelial cell chemotaxis", "Positive regulation of endothelial cell chemotaxis by vegf activated vascular endothelial growth factor receptor signaling pathway", "Positive regulation of endothelial cell development", "Positive regulation of endothelial cell differentiation", "Positive regulation of endothelial cell migration", "Positive regulation of endothelial cell proliferation", "Positive regulation of epidermal cell differentiation", "Positive regulation of epidermis development", "Positive regulation of epithelial cell apoptotic process", "Positive regulation of epithelial cell differentiation", "Positive regulation of epithelial cell migration", "Positive regulation of epithelial cell proliferation", "Positive regulation of epithelial cell proliferation involved in lung morphogenesis", "Positive regulation of epithelial to mesenchymal transition", "Positive regulation of er associated ubiquitin dependent protein catabolic process", "Positive regulation of erad pathway", "Positive regulation of erbb signaling pathway", "Positive regulation of erk1 and erk2 cascade", "Positive regulation of erythrocyte differentiation", "Positive regulation of establishment of protein localization", "Positive regulation of establishment of protein localization to mitochondrion", "Positive regulation of establishment of protein localization to telomere", "Positive regulation of excitatory postsynaptic potential", "Positive regulation of execution phase of apoptosis", "Positive regulation of exocytosis", "Positive regulation of exosomal secretion", "Positive regulation of extracellular matrix assembly", "Positive regulation of extracellular matrix disassembly", "Positive regulation of extracellular matrix organization", "Positive regulation of extrinsic apoptotic signaling pathway", "Positive regulation of extrinsic apoptotic signaling pathway in absence of ligand", "Positive regulation of extrinsic apoptotic signaling pathway via death domain receptors", "Positive regulation of fat cell differentiation", "Positive regulation of fatty acid beta oxidation", "Positive regulation of fatty acid biosynthetic process", "Positive regulation of fatty acid metabolic process", "Positive regulation of fatty acid oxidation", "Positive regulation of fatty acid transport", "Positive regulation of fc receptor mediated stimulatory signaling pathway", "Positive regulation of feeding behavior", "Positive regulation of fibroblast growth factor receptor signaling pathway", "Positive regulation of fibroblast migration", "Positive regulation of fibroblast proliferation", "Positive regulation of filopodium assembly", "Positive regulation of focal adhesion assembly", "Positive regulation of g protein coupled receptor signaling pathway", "Positive regulation of g0 to g1 transition", "Positive regulation of g1 s transition of mitotic cell cycle", "Positive regulation of gastrulation", "Positive regulation of gene expression", "Positive regulation of glial cell differentiation", "Positive regulation of glial cell migration", "Positive regulation of glial cell proliferation", "Positive regulation of gliogenesis", "Positive regulation of glucokinase activity", "Positive regulation of gluconeogenesis", "Positive regulation of glucose import", "Positive regulation of glucose metabolic process", "Positive regulation of glucose transmembrane transport", "Positive regulation of glutamate secretion", "Positive regulation of glycogen metabolic process", "Positive regulation of glycolytic process", "Positive regulation of glycoprotein metabolic process", "Positive regulation of golgi to plasma membrane protein transport", "Positive regulation of gonad development", "Positive regulation of granulocyte chemotaxis", "Positive regulation of growth", "Positive regulation of gtpase activity", "Positive regulation of hair follicle development", "Positive regulation of hair follicle maturation", "Positive regulation of heart growth", "Positive regulation of heart rate", "Positive regulation of helicase activity", "Positive regulation of hematopoietic progenitor cell differentiation", "Positive regulation of hematopoietic stem cell proliferation", "Positive regulation of hemopoiesis", "Positive regulation of heterotypic cell cell adhesion", "Positive regulation of hexokinase activity", "Positive regulation of hippo signaling", "Positive regulation of histone acetylation", "Positive regulation of histone deacetylation", "Positive regulation of histone h3 k27 methylation", "Positive regulation of histone h3 k4 methylation", "Positive regulation of histone h3 k9 acetylation", "Positive regulation of histone h3 k9 methylation", "Positive regulation of histone h4 acetylation", "Positive regulation of histone methylation", "Positive regulation of histone modification", "Positive regulation of histone phosphorylation", "Positive regulation of histone ubiquitination", "Positive regulation of homotypic cell cell adhesion", "Positive regulation of hormone biosynthetic process", "Positive regulation of hormone metabolic process", "Positive regulation of hormone secretion", "Positive regulation of humoral immune response", "Positive regulation of hydrogen peroxide mediated programmed cell death", "Positive regulation of hydrogen peroxide metabolic process", "Positive regulation of hydrolase activity", "Positive regulation of i kappab kinase nf kappab signaling", "Positive regulation of i kappab phosphorylation", "Positive regulation of immune effector process", "Positive regulation of immune response", "Positive regulation of immune system process", "Positive regulation of immunoglobulin production", "Positive regulation of inclusion body assembly", "Positive regulation of inflammatory response", "Positive regulation of inflammatory response to antigenic stimulus", "Positive regulation of innate immune response", "Positive regulation of insulin like growth factor receptor signaling pathway", "Positive regulation of insulin secretion", "Positive regulation of insulin secretion involved in cellular response to glucose stimulus", "Positive regulation of integrin activation", "Positive regulation of integrin mediated signaling pathway", "Positive regulation of interferon alpha production", "Positive regulation of interferon beta production", "Positive regulation of interferon gamma production", "Positive regulation of interleukin 1 alpha production", "Positive regulation of interleukin 1 beta production", "Positive regulation of interleukin 1 production", "Positive regulation of interleukin 10 production", "Positive regulation of interleukin 12 production", "Positive regulation of interleukin 13 production", "Positive regulation of interleukin 17 production", "Positive regulation of interleukin 18 production", "Positive regulation of interleukin 2 production", "Positive regulation of interleukin 6 production", "Positive regulation of interleukin 8 production", "Positive regulation of intracellular lipid transport", "Positive regulation of intracellular protein transport", "Positive regulation of intracellular signal transduction", "Positive regulation of intracellular steroid hormone receptor signaling pathway", "Positive regulation of intracellular transport", "Positive regulation of intrinsic apoptotic signaling pathway", "Positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator", "Positive regulation of intrinsic apoptotic signaling pathway in response to dna damage", "Positive regulation of ion transmembrane transport", "Positive regulation of ion transport", "Positive regulation of ire1 mediated unfolded protein response", "Positive regulation of isotype switching", "Positive regulation of isotype switching to iga isotypes", "Positive regulation of isotype switching to igg isotypes", "Positive regulation of jnk cascade", "Positive regulation of jun kinase activity", "Positive regulation of keratinocyte differentiation", "Positive regulation of keratinocyte proliferation", "Positive regulation of kinase activity", "Positive regulation of lamellipodium assembly", "Positive regulation of lamellipodium morphogenesis", "Positive regulation of lamellipodium organization", "Positive regulation of leukocyte apoptotic process", "Positive regulation of leukocyte cell cell adhesion", "Positive regulation of leukocyte chemotaxis", "Positive regulation of leukocyte degranulation", "Positive regulation of leukocyte mediated immunity", "Positive regulation of leukocyte migration", "Positive regulation of leukocyte proliferation", "Positive regulation of ligase activity", "Positive regulation of lipase activity", "Positive regulation of lipid biosynthetic process", "Positive regulation of lipid catabolic process", "Positive regulation of lipid kinase activity", "Positive regulation of lipid localization", "Positive regulation of lipid metabolic process", "Positive regulation of lipid storage", "Positive regulation of lipid transport", "Positive regulation of lipopolysaccharide mediated signaling pathway", "Positive regulation of lipoprotein particle clearance", "Positive regulation of locomotion", "Positive regulation of long term synaptic depression", "Positive regulation of long term synaptic potentiation", "Positive regulation of low density lipoprotein receptor activity", "Positive regulation of lyase activity", "Positive regulation of lymphocyte anergy", "Positive regulation of lymphocyte apoptotic process", "Positive regulation of lymphocyte chemotaxis", "Positive regulation of lymphocyte differentiation", "Positive regulation of lymphocyte mediated immunity", "Positive regulation of lymphocyte migration", "Positive regulation of macroautophagy", "Positive regulation of macrophage activation", "Positive regulation of macrophage chemotaxis", "Positive regulation of macrophage cytokine production", "Positive regulation of macrophage migration", "Positive regulation of maintenance of sister chromatid cohesion", "Positive regulation of mammary gland epithelial cell proliferation", "Positive regulation of map kinase activity", "Positive regulation of mapk cascade", "Positive regulation of mast cell activation", "Positive regulation of mast cell activation involved in immune response", "Positive regulation of megakaryocyte differentiation", "Positive regulation of meiotic cell cycle", "Positive regulation of membrane depolarization", "Positive regulation of membrane permeability", "Positive regulation of membrane potential", "Positive regulation of membrane protein ectodomain proteolysis", "Positive regulation of mesenchymal cell proliferation", "Positive regulation of mesenchymal stem cell proliferation", "Positive regulation of metalloendopeptidase activity", "Positive regulation of metallopeptidase activity", "Positive regulation of metaphase anaphase transition of cell cycle", "Positive regulation of mhc class i biosynthetic process", "Positive regulation of mhc class ii biosynthetic process", "Positive regulation of microglial cell activation", "Positive regulation of microtubule binding", "Positive regulation of microtubule nucleation", "Positive regulation of microtubule polymerization or depolymerization", "Positive regulation of mirna catabolic process", "Positive regulation of mirna mediated gene silencing by inhibition of translation", "Positive regulation of mirna metabolic process", "Positive regulation of mirna transcription", "Positive regulation of mitochondrial calcium ion concentration", "Positive regulation of mitochondrial depolarization", "Positive regulation of mitochondrial fission", "Positive regulation of mitochondrial membrane potential", "Positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway", "Positive regulation of mitochondrial translation", "Positive regulation of mitochondrion organization", "Positive regulation of mitophagy", "Positive regulation of mitophagy in response to mitochondrial depolarization", "Positive regulation of mitotic cell cycle", "Positive regulation of mitotic cell cycle phase transition", "Positive regulation of mitotic cell cycle spindle assembly checkpoint", "Positive regulation of mitotic nuclear division", "Positive regulation of molecular function", "Positive regulation of monocyte chemotaxis", "Positive regulation of monocyte differentiation", "Positive regulation of mononuclear cell migration", "Positive regulation of monooxygenase activity", "Positive regulation of morphogenesis of an epithelium", "Positive regulation of mrna 3 end processing", "Positive regulation of mrna metabolic process", "Positive regulation of mrna processing", "Positive regulation of mrna splicing via spliceosome", "Positive regulation of multicellular organism growth", "Positive regulation of multicellular organismal process", "Positive regulation of muscle adaptation", "Positive regulation of muscle cell apoptotic process", "Positive regulation of muscle cell differentiation", "Positive regulation of muscle contraction", "Positive regulation of muscle hypertrophy", "Positive regulation of muscle tissue development", "Positive regulation of myelination", "Positive regulation of myeloid cell apoptotic process", "Positive regulation of myeloid cell differentiation", "Positive regulation of myeloid leukocyte cytokine production involved in immune response", "Positive regulation of myeloid leukocyte differentiation", "Positive regulation of myeloid leukocyte mediated immunity", "Positive regulation of myoblast differentiation", "Positive regulation of myoblast fusion", "Positive regulation of myotube differentiation", "Positive regulation of nad p h oxidase activity", "Positive regulation of natural killer cell activation", "Positive regulation of natural killer cell mediated cytotoxicity", "Positive regulation of natural killer cell mediated immunity", "Positive regulation of necrotic cell death", "Positive regulation of nervous system development", "Positive regulation of nervous system process", "Positive regulation of neural precursor cell proliferation", "Positive regulation of neuroblast proliferation", "Positive regulation of neurogenesis", "Positive regulation of neuroinflammatory response", "Positive regulation of neuron apoptotic process", "Positive regulation of neuron death", "Positive regulation of neuron differentiation", "Positive regulation of neuron migration", "Positive regulation of neuron projection development", "Positive regulation of neuron projection regeneration", "Positive regulation of neurotransmitter secretion", "Positive regulation of neurotransmitter transport", "Positive regulation of neurotransmitter uptake", "Positive regulation of neurotrophin trk receptor signaling pathway", "Positive regulation of neutrophil migration", "Positive regulation of nf kappab transcription factor activity", "Positive regulation of nik nf kappab signaling", "Positive regulation of nitric oxide metabolic process", "Positive regulation of nitric oxide synthase activity", "Positive regulation of nitric oxide synthase biosynthetic process", "Positive regulation of nk t cell activation", "Positive regulation of nlrp3 inflammasome complex assembly", "Positive regulation of non motile cilium assembly", "Positive regulation of notch signaling pathway", "Positive regulation of nuclear cell cycle dna replication", "Positive regulation of nuclear division", "Positive regulation of nuclear transcribed mrna catabolic process deadenylation dependent decay", "Positive regulation of nuclease activity", "Positive regulation of nucleobase containing compound metabolic process", "Positive regulation of nucleobase containing compound transport", "Positive regulation of nucleocytoplasmic transport", "Positive regulation of nucleotide binding oligomerization domain containing 2 signaling pathway", "Positive regulation of nucleotide binding oligomerization domain containing signaling pathway", "Positive regulation of nucleotide biosynthetic process", "Positive regulation of nucleotide metabolic process", "Positive regulation of oligodendrocyte differentiation", "Positive regulation of organ growth", "Positive regulation of organelle assembly", "Positive regulation of organelle organization", "Positive regulation of organic acid transport", "Positive regulation of ossification", "Positive regulation of osteoblast differentiation", "Positive regulation of oxidative stress induced cell death", "Positive regulation of oxidative stress induced intrinsic apoptotic signaling pathway", "Positive regulation of oxidative stress induced neuron death", "Positive regulation of oxidoreductase activity", "Positive regulation of p38mapk cascade", "Positive regulation of pathway restricted smad protein phosphorylation", "Positive regulation of pattern recognition receptor signaling pathway", "Positive regulation of peptidase activity", "Positive regulation of peptide secretion", "Positive regulation of peptidyl lysine acetylation", "Positive regulation of peptidyl serine phosphorylation", "Positive regulation of peptidyl threonine phosphorylation", "Positive regulation of peptidyl tyrosine phosphorylation", "Positive regulation of peroxisome proliferator activated receptor signaling pathway", "Positive regulation of phagocytosis", "Positive regulation of phosphatase activity", "Positive regulation of phosphatidylinositol 3 kinase signaling", "Positive regulation of phospholipase a2 activity", "Positive regulation of phospholipase activity", "Positive regulation of phospholipid biosynthetic process", "Positive regulation of phospholipid metabolic process", "Positive regulation of phospholipid translocation", "Positive regulation of phosphoprotein phosphatase activity", "Positive regulation of phosphorus metabolic process", "Positive regulation of pinocytosis", "Positive regulation of plasma membrane bounded cell projection assembly", "Positive regulation of plasminogen activation", "Positive regulation of platelet aggregation", "Positive regulation of podosome assembly", "Positive regulation of posttranscriptional gene silencing", "Positive regulation of potassium ion import across plasma membrane", "Positive regulation of potassium ion transmembrane transporter activity", "Positive regulation of potassium ion transport", "Positive regulation of production of mirnas involved in gene silencing by mirna", "Positive regulation of production of molecular mediator of immune response", "Positive regulation of programmed necrotic cell death", "Positive regulation of prostaglandin biosynthetic process", "Positive regulation of proteasomal ubiquitin dependent protein catabolic process", "Positive regulation of protein acetylation", "Positive regulation of protein autophosphorylation", "Positive regulation of protein binding", "Positive regulation of protein catabolic process", "Positive regulation of protein catabolic process in the vacuole", "Positive regulation of protein containing complex assembly", "Positive regulation of protein containing complex disassembly", "Positive regulation of protein deacetylation", "Positive regulation of protein dephosphorylation", "Positive regulation of protein depolymerization", "Positive regulation of protein deubiquitination", "Positive regulation of protein exit from endoplasmic reticulum", "Positive regulation of protein export from nucleus", "Positive regulation of protein glycosylation", "Positive regulation of protein import", "Positive regulation of protein k63 linked ubiquitination", "Positive regulation of protein kinase a signaling", "Positive regulation of protein kinase activity", "Positive regulation of protein kinase b signaling", "Positive regulation of protein kinase c signaling", "Positive regulation of protein localization", "Positive regulation of protein localization to cell cortex", "Positive regulation of protein localization to cell periphery", "Positive regulation of protein localization to cell surface", "Positive regulation of protein localization to centrosome", "Positive regulation of protein localization to early endosome", "Positive regulation of protein localization to membrane", "Positive regulation of protein localization to nucleus", "Positive regulation of protein maturation", "Positive regulation of protein metabolic process", "Positive regulation of protein modification by small protein conjugation or removal", "Positive regulation of protein modification process", "Positive regulation of protein monoubiquitination", "Positive regulation of protein neddylation", "Positive regulation of protein phosphorylation", "Positive regulation of protein polymerization", "Positive regulation of protein polyubiquitination", "Positive regulation of protein secretion", "Positive regulation of protein serine threonine kinase activity", "Positive regulation of protein sumoylation", "Positive regulation of protein targeting to membrane", "Positive regulation of protein tyrosine kinase activity", "Positive regulation of proteolysis", "Positive regulation of proteolysis involved in cellular protein catabolic process", "Positive regulation of pseudopodium assembly", "Positive regulation of reactive oxygen species biosynthetic process", "Positive regulation of reactive oxygen species metabolic process", "Positive regulation of receptor binding", "Positive regulation of receptor catabolic process", "Positive regulation of receptor internalization", "Positive regulation of receptor mediated endocytosis", "Positive regulation of receptor recycling", "Positive regulation of receptor signaling pathway via stat", "Positive regulation of regulated secretory pathway", "Positive regulation of release of cytochrome c from mitochondria", "Positive regulation of release of sequestered calcium ion into cytosol", "Positive regulation of renal sodium excretion", "Positive regulation of reproductive process", "Positive regulation of respiratory burst", "Positive regulation of response to biotic stimulus", "Positive regulation of response to cytokine stimulus", "Positive regulation of response to dna damage stimulus", "Positive regulation of response to endoplasmic reticulum stress", "Positive regulation of response to external stimulus", "Positive regulation of response to oxidative stress", "Positive regulation of response to reactive oxygen species", "Positive regulation of response to tumor cell", "Positive regulation of response to wounding", "Positive regulation of retinoic acid receptor signaling pathway", "Positive regulation of rho protein signal transduction", "Positive regulation of rig i signaling pathway", "Positive regulation of rna binding", "Positive regulation of rna export from nucleus", "Positive regulation of rna metabolic process", "Positive regulation of rna polymerase ii transcription preinitiation complex assembly", "Positive regulation of rna splicing", "Positive regulation of rrna processing", "Positive regulation of ruffle assembly", "Positive regulation of ryanodine sensitive calcium release channel activity", "Positive regulation of secretion", "Positive regulation of sequestering of calcium ion", "Positive regulation of sequestering of triglyceride", "Positive regulation of signal transduction by p53 class mediator", "Positive regulation of signaling", "Positive regulation of signaling receptor activity", "Positive regulation of sister chromatid cohesion", "Positive regulation of skeletal muscle tissue development", "Positive regulation of smad protein signal transduction", "Positive regulation of small gtpase mediated signal transduction", "Positive regulation of small molecule metabolic process", "Positive regulation of smooth muscle cell apoptotic process", "Positive regulation of smooth muscle cell differentiation", "Positive regulation of smooth muscle cell migration", "Positive regulation of smooth muscle cell proliferation", "Positive regulation of smooth muscle contraction", "Positive regulation of smoothened signaling pathway", "Positive regulation of sodium ion transmembrane transport", "Positive regulation of sodium ion transmembrane transporter activity", "Positive regulation of sodium ion transport", "Positive regulation of sphingolipid biosynthetic process", "Positive regulation of spindle assembly", "Positive regulation of sprouting angiogenesis", "Positive regulation of stem cell differentiation", "Positive regulation of stem cell proliferation", "Positive regulation of steroid biosynthetic process", "Positive regulation of steroid hormone biosynthetic process", "Positive regulation of steroid hormone secretion", "Positive regulation of steroid metabolic process", "Positive regulation of sterol transport", "Positive regulation of store operated calcium channel activity", "Positive regulation of stress activated protein kinase signaling cascade", "Positive regulation of stress fiber assembly", "Positive regulation of striated muscle cell apoptotic process", "Positive regulation of striated muscle cell differentiation", "Positive regulation of striated muscle contraction", "Positive regulation of substrate adhesion dependent cell spreading", "Positive regulation of supramolecular fiber organization", "Positive regulation of synapse assembly", "Positive regulation of synapse maturation", "Positive regulation of synaptic plasticity", "Positive regulation of synaptic transmission", "Positive regulation of synaptic transmission gabaergic", "Positive regulation of synaptic transmission glutamatergic", "Positive regulation of synaptic vesicle endocytosis", "Positive regulation of synaptic vesicle exocytosis", "Positive regulation of synaptic vesicle recycling", "Positive regulation of syncytium formation by plasma membrane fusion", "Positive regulation of t cell apoptotic process", "Positive regulation of t cell cytokine production", "Positive regulation of t cell mediated cytotoxicity", "Positive regulation of t cell mediated immune response to tumor cell", "Positive regulation of t cell mediated immunity", "Positive regulation of t cell migration", "Positive regulation of t cell proliferation", "Positive regulation of t cell receptor signaling pathway", "Positive regulation of t cell tolerance induction", "Positive regulation of t helper 1 cell differentiation", "Positive regulation of t helper cell differentiation", "Positive regulation of tau protein kinase activity", "Positive regulation of telomerase activity", "Positive regulation of telomerase rna localization to cajal body", "Positive regulation of telomere capping", "Positive regulation of telomere maintenance", "Positive regulation of telomere maintenance via telomere lengthening", "Positive regulation of tissue remodeling", "Positive regulation of tolerance induction", "Positive regulation of toll like receptor 3 signaling pathway", "Positive regulation of toll like receptor 9 signaling pathway", "Positive regulation of toll like receptor signaling pathway", "Positive regulation of tor signaling", "Positive regulation of torc1 signaling", "Positive regulation of transcription by rna polymerase i", "Positive regulation of transcription by rna polymerase ii", "Positive regulation of transcription by rna polymerase iii", "Positive regulation of transcription elongation from rna polymerase ii promoter", "Positive regulation of transcription from rna polymerase ii promoter in response to endoplasmic reticulum stress", "Positive regulation of transcription from rna polymerase ii promoter in response to hypoxia", "Positive regulation of transcription from rna polymerase ii promoter in response to stress", "Positive regulation of transcription from rna polymerase ii promoter involved in cellular response to chemical stimulus", "Positive regulation of transcription of nucleolar large rrna by rna polymerase i", "Positive regulation of transcription regulatory region dna binding", "Positive regulation of transferase activity", "Positive regulation of transforming growth factor beta production", "Positive regulation of transforming growth factor beta1 production", "Positive regulation of translation", "Positive regulation of translation in response to endoplasmic reticulum stress", "Positive regulation of translation in response to stress", "Positive regulation of translational initiation", "Positive regulation of transmembrane receptor protein serine threonine kinase signaling pathway", "Positive regulation of transmembrane transport", "Positive regulation of transmission of nerve impulse", "Positive regulation of transport", "Positive regulation of transporter activity", "Positive regulation of triglyceride biosynthetic process", "Positive regulation of triglyceride metabolic process", "Positive regulation of trophoblast cell migration", "Positive regulation of tumor necrosis factor mediated signaling pathway", "Positive regulation of tumor necrosis factor superfamily cytokine production", "Positive regulation of type i interferon mediated signaling pathway", "Positive regulation of type i interferon production", "Positive regulation of tyrosine phosphorylation of stat protein", "Positive regulation of ubiquitin dependent protein catabolic process", "Positive regulation of ubiquitin protein ligase activity", "Positive regulation of ubiquitin protein transferase activity", "Positive regulation of unsaturated fatty acid biosynthetic process", "Positive regulation of urine volume", "Positive regulation of vacuole organization", "Positive regulation of vascular associated smooth muscle cell apoptotic process", "Positive regulation of vascular associated smooth muscle cell differentiation", "Positive regulation of vascular associated smooth muscle cell migration", "Positive regulation of vascular associated smooth muscle cell proliferation", "Positive regulation of vascular endothelial cell proliferation", "Positive regulation of vascular endothelial growth factor receptor signaling pathway", "Positive regulation of vascular endothelial growth factor signaling pathway", "Positive regulation of vascular permeability", "Positive regulation of vasculature development", "Positive regulation of vasculogenesis", "Positive regulation of vesicle fusion", "Positive regulation of viral genome replication", "Positive regulation of viral life cycle", "Positive regulation of viral process", "Positive regulation of vitamin d receptor signaling pathway", "Positive regulation of voltage gated calcium channel activity", "Positive regulation of wnt signaling pathway", "Positive regulation of wound healing", "Positive regulation of wound healing spreading of epidermal cells", "Positive t cell selection", "Post anal tail morphogenesis", "Post chaperonin tubulin folding pathway", "Post embryonic animal morphogenesis", "Post embryonic animal organ development", "Post embryonic animal organ morphogenesis", "Post embryonic camera type eye development", "Post embryonic development", "Post embryonic eye morphogenesis", "Post golgi vesicle mediated transport", "Post translational protein modification", "Postreplication repair", "Postsynapse assembly", "Postsynapse organization", "Postsynapse to nucleus signaling pathway", "Postsynaptic actin cytoskeleton organization", "Postsynaptic cytoskeleton organization", "Postsynaptic density protein 95 clustering", "Postsynaptic membrane assembly", "Postsynaptic membrane organization", "Postsynaptic modulation of chemical synaptic transmission", "Postsynaptic neurotransmitter receptor internalization", "Postsynaptic signal transduction", "Postsynaptic specialization organization", "Posttranscriptional regulation of gene expression", "Posttranslational protein targeting to endoplasmic reticulum membrane", "Posttranslational protein targeting to membrane translocation", "Potassium ion export across plasma membrane", "Potassium ion homeostasis", "Potassium ion import across plasma membrane", "Potassium ion transport", "Pre mirna processing", "Prenylation", "Presynapse organization", "Presynaptic active zone organization", "Presynaptic endocytosis", "Presynaptic modulation of chemical synaptic transmission", "Prevention of polyspermy", "Primary alcohol biosynthetic process", "Primary alcohol catabolic process", "Primary alcohol metabolic process", "Primary amino compound biosynthetic process", "Primary amino compound metabolic process", "Primary mirna processing", "Primitive hemopoiesis", "Pro b cell differentiation", "Process utilizing autophagic mechanism", "Production of molecular mediator involved in inflammatory response", "Production of molecular mediator of immune response", "Production of sirna involved in rna interference", "Progesterone biosynthetic process", "Progesterone metabolic process", "Progesterone receptor signaling pathway", "Programmed cell death", "Programmed cell death in response to reactive oxygen species", "Programmed cell death involved in cell development", "Programmed necrotic cell death", "Prolactin secretion", "Proline metabolic process", "Proline transport", "Pronephros development", "Proprioception", "Prostaglandin transport", "Prostanoid biosynthetic process", "Prostanoid metabolic process", "Prostate gland development", "Prostate gland growth", "Prosthetic group metabolic process", "Proteasomal protein catabolic process", "Proteasome assembly", "Proteasome mediated ubiquitin dependent protein catabolic process", "Protection from natural killer cell mediated cytotoxicity", "Protection from non homologous end joining at telomere", "Protein acetylation", "Protein activation cascade", "Protein acylation", "Protein adp ribosylation", "Protein auto adp ribosylation", "Protein autophosphorylation", "Protein autoprocessing", "Protein autoubiquitination", "Protein catabolic process", "Protein catabolic process in the vacuole", "Protein complex oligomerization", "Protein containing complex disassembly", "Protein containing complex localization", "Protein containing complex organization", "Protein containing complex remodeling", "Protein de adp ribosylation", "Protein deglycosylation", "Protein demannosylation", "Protein demethylation", "Protein deneddylation", "Protein depalmitoylation", "Protein dephosphorylation", "Protein depolymerization", "Protein destabilization", "Protein desumoylation", "Protein deubiquitination involved in ubiquitin dependent protein catabolic process", "Protein dna complex assembly", "Protein dna complex disassembly", "Protein dna complex subunit organization", "Protein dna covalent cross linking repair", "Protein exit from endoplasmic reticulum", "Protein export from nucleus", "Protein folding", "Protein folding in endoplasmic reticulum", "Protein geranylgeranylation", "Protein heterooligomerization", "Protein heterotetramerization", "Protein hexamerization", "Protein homooligomerization", "Protein homotetramerization", "Protein hydroxylation", "Protein import", "Protein import into mitochondrial matrix", "Protein import into peroxisome matrix", "Protein import into peroxisome membrane", "Protein insertion into er membrane", "Protein insertion into er membrane by stop transfer membrane anchor sequence", "Protein insertion into membrane", "Protein insertion into mitochondrial inner membrane", "Protein insertion into mitochondrial membrane involved in apoptotic signaling pathway", "Protein k11 linked deubiquitination", "Protein k11 linked ubiquitination", "Protein k27 linked ubiquitination", "Protein k29 linked ubiquitination", "Protein k48 linked deubiquitination", "Protein k48 linked ubiquitination", "Protein k6 linked ubiquitination", "Protein k63 linked deubiquitination", "Protein k63 linked ubiquitination", "Protein kinase a signaling", "Protein kinase b signaling", "Protein kinase c activating g protein coupled receptor signaling pathway", "Protein kinase c signaling", "Protein lipid complex assembly", "Protein lipid complex subunit organization", "Protein localization to adherens junction", "Protein localization to axon", "Protein localization to basolateral plasma membrane", "Protein localization to cell cell junction", "Protein localization to cell cortex", "Protein localization to cell junction", "Protein localization to cell periphery", "Protein localization to cell surface", "Protein localization to chromatin", "Protein localization to chromosome", "Protein localization to chromosome centromeric region", "Protein localization to chromosome telomeric region", "Protein localization to ciliary membrane", "Protein localization to cilium", "Protein localization to condensed chromosome", "Protein localization to cytoplasmic stress granule", "Protein localization to cytoskeleton", "Protein localization to early endosome", "Protein localization to endoplasmic reticulum", "Protein localization to endoplasmic reticulum exit site", "Protein localization to endosome", "Protein localization to extracellular region", "Protein localization to golgi apparatus", "Protein localization to lysosome", "Protein localization to membrane raft", "Protein localization to microtubule", "Protein localization to microtubule end", "Protein localization to microtubule organizing center", "Protein localization to mitochondrion", "Protein localization to nuclear body", "Protein localization to nuclear envelope", "Protein localization to nucleolus", "Protein localization to nucleoplasm", "Protein localization to nucleus", "Protein localization to organelle", "Protein localization to perinuclear region of cytoplasm", "Protein localization to phagophore assembly site", "Protein localization to plasma membrane", "Protein localization to postsynapse", "Protein localization to presynapse", "Protein localization to synapse", "Protein localization to vacuole", "Protein mannosylation", "Protein maturation", "Protein maturation by iron sulfur cluster transfer", "Protein maturation by protein folding", "Protein methylation", "Protein modification by small protein conjugation", "Protein modification by small protein conjugation or removal", "Protein modification by small protein removal", "Protein monoubiquitination", "Protein n linked glycosylation", "Protein neddylation", "Protein nitrosylation", "Protein o linked fucosylation", "Protein o linked glycosylation", "Protein o linked glycosylation via serine", "Protein o linked glycosylation via threonine", "Protein o linked mannosylation", "Protein oxidation", "Protein palmitoylation", "Protein peptidyl prolyl isomerization", "Protein poly adp ribosylation", "Protein polyglutamylation", "Protein polymerization", "Protein polyubiquitination", "Protein polyufmylation", "Protein processing", "Protein processing involved in protein targeting to mitochondrion", "Protein quality control for misfolded or incompletely synthesized proteins", "Protein refolding", "Protein repair", "Protein retention in er lumen", "Protein retention in golgi apparatus", "Protein stabilization", "Protein sumoylation", "Protein targeting", "Protein targeting to lysosome", "Protein targeting to membrane", "Protein targeting to mitochondrion", "Protein targeting to peroxisome", "Protein targeting to vacuole", "Protein tetramerization", "Protein transmembrane import into intracellular organelle", "Protein transmembrane transport", "Protein transport along microtubule", "Protein transport to vacuole involved in ubiquitin dependent protein catabolic process via the multivesicular body sorting pathway", "Protein transport within lipid bilayer", "Protein trimerization", "Protein ufmylation", "Proteoglycan biosynthetic process", "Proteoglycan metabolic process", "Proteolysis", "Proton transmembrane transport", "Proton transporting two sector atpase complex assembly", "Proton transporting v type atpase complex assembly", "Protoporphyrinogen ix biosynthetic process", "Protoporphyrinogen ix metabolic process", "Proximal distal pattern formation", "Proximal distal pattern formation involved in nephron development", "Proximal tubule development", "Pseudopodium organization", "Pseudouridine synthesis", "Pteridine containing compound biosynthetic process", "Pteridine containing compound metabolic process", "Pulmonary artery morphogenesis", "Pulmonary valve development", "Pulmonary valve morphogenesis", "Purine containing compound biosynthetic process", "Purine containing compound catabolic process", "Purine containing compound metabolic process", "Purine containing compound salvage", "Purine containing compound transmembrane transport", "Purine deoxyribonucleoside metabolic process", "Purine deoxyribonucleoside monophosphate catabolic process", "Purine deoxyribonucleoside monophosphate metabolic process", "Purine deoxyribonucleoside triphosphate metabolic process", "Purine deoxyribonucleotide catabolic process", "Purine deoxyribonucleotide metabolic process", "Purine nucleobase biosynthetic process", "Purine nucleobase metabolic process", "Purine nucleoside biosynthetic process", "Purine nucleoside catabolic process", "Purine nucleoside diphosphate biosynthetic process", "Purine nucleoside diphosphate catabolic process", "Purine nucleoside metabolic process", "Purine nucleoside monophosphate biosynthetic process", "Purine nucleoside monophosphate catabolic process", "Purine nucleoside monophosphate metabolic process", "Purine nucleoside triphosphate catabolic process", "Purine nucleotide catabolic process", "Purine nucleotide salvage", "Purine nucleotide transport", "Purine ribonucleoside catabolic process", "Purine ribonucleoside metabolic process", "Purine ribonucleoside salvage", "Purine ribonucleotide salvage", "Purinergic nucleotide receptor signaling pathway", "Pyramidal neuron development", "Pyramidal neuron differentiation", "Pyridine containing compound biosynthetic process", "Pyridine containing compound catabolic process", "Pyridine containing compound metabolic process", "Pyridine nucleotide biosynthetic process", "Pyridine nucleotide metabolic process", "Pyrimidine containing compound biosynthetic process", "Pyrimidine containing compound catabolic process", "Pyrimidine containing compound metabolic process", "Pyrimidine containing compound salvage", "Pyrimidine containing compound transmembrane transport", "Pyrimidine deoxyribonucleoside metabolic process", "Pyrimidine deoxyribonucleoside monophosphate biosynthetic process", "Pyrimidine deoxyribonucleoside monophosphate metabolic process", "Pyrimidine deoxyribonucleoside triphosphate metabolic process", "Pyrimidine deoxyribonucleotide biosynthetic process", "Pyrimidine deoxyribonucleotide metabolic process", "Pyrimidine dimer repair", "Pyrimidine nucleobase biosynthetic process", "Pyrimidine nucleobase catabolic process", "Pyrimidine nucleobase metabolic process", "Pyrimidine nucleoside diphosphate biosynthetic process", "Pyrimidine nucleoside diphosphate metabolic process", "Pyrimidine nucleoside metabolic process", "Pyrimidine nucleoside monophosphate biosynthetic process", "Pyrimidine nucleoside monophosphate metabolic process", "Pyrimidine nucleoside triphosphate biosynthetic process", "Pyrimidine nucleoside triphosphate metabolic process", "Pyrimidine nucleotide catabolic process", "Pyrimidine nucleotide metabolic process", "Pyrimidine ribonucleoside diphosphate metabolic process", "Pyrimidine ribonucleoside monophosphate metabolic process", "Pyrimidine ribonucleoside triphosphate biosynthetic process", "Pyrimidine ribonucleoside triphosphate metabolic process", "Pyrimidine ribonucleotide biosynthetic process", "Pyrimidine ribonucleotide metabolic process", "Pyroptosis", "Pyruvate metabolic process", "Pyruvate transmembrane transport", "Pyruvate transport", "Quaternary ammonium group transport", "Quinone metabolic process", "R loop disassembly", "Rab protein signal transduction", "Rac protein signal transduction", "Radial glial cell differentiation", "Rap protein signal transduction", "Ras protein signal transduction", "Reactive nitrogen species metabolic process", "Reactive oxygen species biosynthetic process", "Reactive oxygen species metabolic process", "Receptor catabolic process", "Receptor clustering", "Receptor diffusion trapping", "Receptor internalization", "Receptor localization to synapse", "Receptor mediated endocytosis", "Receptor mediated endocytosis involved in cholesterol transport", "Receptor metabolic process", "Receptor recycling", "Receptor signaling pathway via stat", "Recognition of apoptotic cell", "Recombinational repair", "Reelin mediated signaling pathway", "Reflex", "Regeneration", "Regionalization", "Regulated exocytosis", "Regulation by virus of viral protein levels in host cell", "Regulation of 3 utr mediated mrna stabilization", "Regulation of actin cytoskeleton reorganization", "Regulation of actin filament based movement", "Regulation of actin filament based process", "Regulation of actin filament bundle assembly", "Regulation of actin filament length", "Regulation of actin filament organization", "Regulation of actin nucleation", "Regulation of action potential", "Regulation of activin receptor signaling pathway", "Regulation of actomyosin structure organization", "Regulation of acute inflammatory response", "Regulation of acute inflammatory response to antigenic stimulus", "Regulation of acyl coa biosynthetic process", "Regulation of adaptive immune response", "Regulation of adenylate cyclase activating g protein coupled receptor signaling pathway", "Regulation of adenylate cyclase activity", "Regulation of adherens junction organization", "Regulation of adipose tissue development", "Regulation of aerobic respiration", "Regulation of alcohol biosynthetic process", "Regulation of alpha beta t cell activation", "Regulation of alpha beta t cell differentiation", "Regulation of alternative mrna splicing via spliceosome", "Regulation of amino acid transmembrane transport", "Regulation of amino acid transport", "Regulation of amyloid beta clearance", "Regulation of amyloid fibril formation", "Regulation of amyloid precursor protein catabolic process", "Regulation of anaphase promoting complex dependent catabolic process", "Regulation of anatomical structure morphogenesis", "Regulation of anatomical structure size", "Regulation of androgen receptor signaling pathway", "Regulation of angiotensin levels in blood", "Regulation of animal organ formation", "Regulation of animal organ morphogenesis", "Regulation of anion channel activity", "Regulation of anion transmembrane transport", "Regulation of anion transport", "Regulation of anoikis", "Regulation of antigen receptor mediated signaling pathway", "Regulation of apoptotic cell clearance", "Regulation of apoptotic dna fragmentation", "Regulation of apoptotic signaling pathway", "Regulation of appetite", "Regulation of arachidonic acid secretion", "Regulation of arp2 3 complex mediated actin nucleation", "Regulation of aspartic type endopeptidase activity involved in amyloid precursor protein catabolic process", "Regulation of aspartic type peptidase activity", "Regulation of astrocyte differentiation", "Regulation of atp biosynthetic process", "Regulation of atp dependent activity", "Regulation of atp metabolic process", "Regulation of atpase coupled calcium transmembrane transporter activity", "Regulation of atrial cardiac muscle cell membrane repolarization", "Regulation of attachment of spindle microtubules to kinetochore", "Regulation of autophagic cell death", "Regulation of autophagosome maturation", "Regulation of autophagy", "Regulation of autophagy of mitochondrion", "Regulation of autophagy of mitochondrion in response to mitochondrial depolarization", "Regulation of axon diameter", "Regulation of axon guidance", "Regulation of axonogenesis", "Regulation of b cell activation", "Regulation of b cell apoptotic process", "Regulation of b cell differentiation", "Regulation of b cell mediated immunity", "Regulation of b cell proliferation", "Regulation of b cell receptor signaling pathway", "Regulation of barbed end actin filament capping", "Regulation of behavior", "Regulation of bicellular tight junction assembly", "Regulation of bile acid biosynthetic process", "Regulation of bile acid metabolic process", "Regulation of binding", "Regulation of biological process involved in symbiotic interaction", "Regulation of biomineralization", "Regulation of blood brain barrier permeability", "Regulation of blood circulation", "Regulation of blood pressure", "Regulation of bmp signaling pathway", "Regulation of body fluid levels", "Regulation of bone mineralization", "Regulation of bone remodeling", "Regulation of bone resorption", "Regulation of branching involved in lung morphogenesis", "Regulation of branching morphogenesis of a nerve", "Regulation of brown fat cell differentiation", "Regulation of calcineurin mediated signaling", "Regulation of calcium ion dependent exocytosis", "Regulation of calcium ion export across plasma membrane", "Regulation of calcium ion import", "Regulation of calcium ion transmembrane transport", "Regulation of calcium ion transmembrane transporter activity", "Regulation of calcium ion transport", "Regulation of calcium ion transport into cytosol", "Regulation of calcium mediated signaling", "Regulation of camp dependent protein kinase activity", "Regulation of camp mediated signaling", "Regulation of canonical wnt signaling pathway", "Regulation of carbohydrate biosynthetic process", "Regulation of carbohydrate catabolic process", "Regulation of carbohydrate metabolic process", "Regulation of cardiac conduction", "Regulation of cardiac muscle adaptation", "Regulation of cardiac muscle cell action potential", "Regulation of cardiac muscle cell action potential involved in regulation of contraction", "Regulation of cardiac muscle cell membrane potential", "Regulation of cardiac muscle cell membrane repolarization", "Regulation of cardiac muscle cell proliferation", "Regulation of cardiac muscle contraction", "Regulation of cardiac muscle contraction by calcium ion signaling", "Regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion", "Regulation of cardioblast differentiation", "Regulation of cardiocyte differentiation", "Regulation of cartilage development", "Regulation of catabolic process", "Regulation of catecholamine metabolic process", "Regulation of cation channel activity", "Regulation of cation transmembrane transport", "Regulation of caveolin mediated endocytosis", "Regulation of cd4 positive alpha beta t cell activation", "Regulation of cd4 positive alpha beta t cell differentiation", "Regulation of cd40 signaling pathway", "Regulation of cd8 positive alpha beta t cell activation", "Regulation of cell activation", "Regulation of cell adhesion", "Regulation of cell adhesion mediated by integrin", "Regulation of cell aging", "Regulation of cell cell adhesion", "Regulation of cell cell adhesion mediated by cadherin", "Regulation of cell cell adhesion mediated by integrin", "Regulation of cell communication by electrical coupling", "Regulation of cell communication by electrical coupling involved in cardiac conduction", "Regulation of cell cycle", "Regulation of cell cycle checkpoint", "Regulation of cell cycle g1 s phase transition", "Regulation of cell cycle g2 m phase transition", "Regulation of cell cycle phase transition", "Regulation of cell cycle process", "Regulation of cell death", "Regulation of cell development", "Regulation of cell differentiation", "Regulation of cell division", "Regulation of cell growth involved in cardiac muscle cell development", "Regulation of cell junction assembly", "Regulation of cell killing", "Regulation of cell matrix adhesion", "Regulation of cell maturation", "Regulation of cell migration involved in sprouting angiogenesis", "Regulation of cell morphogenesis", "Regulation of cell morphogenesis involved in differentiation", "Regulation of cell population proliferation", "Regulation of cell projection assembly", "Regulation of cell projection organization", "Regulation of cell projection size", "Regulation of cell shape", "Regulation of cell size", "Regulation of cell substrate adhesion", "Regulation of cell substrate junction organization", "Regulation of cellular amide metabolic process", "Regulation of cellular amine metabolic process", "Regulation of cellular amino acid metabolic process", "Regulation of cellular carbohydrate catabolic process", "Regulation of cellular carbohydrate metabolic process", "Regulation of cellular component biogenesis", "Regulation of cellular component movement", "Regulation of cellular component size", "Regulation of cellular extravasation", "Regulation of cellular ketone metabolic process", "Regulation of cellular localization", "Regulation of cellular macromolecule biosynthetic process", "Regulation of cellular ph", "Regulation of cellular ph reduction", "Regulation of cellular protein catabolic process", "Regulation of cellular respiration", "Regulation of cellular response to growth factor stimulus", "Regulation of cellular response to heat", "Regulation of cellular response to hypoxia", "Regulation of cellular response to insulin stimulus", "Regulation of cellular response to osmotic stress", "Regulation of cellular response to stress", "Regulation of cellular response to transforming growth factor beta stimulus", "Regulation of cellular response to vascular endothelial growth factor stimulus", "Regulation of centriole replication", "Regulation of centrosome cycle", "Regulation of chaperone mediated autophagy", "Regulation of chemokine mediated signaling pathway", "Regulation of chemotaxis", "Regulation of chloride transport", "Regulation of cholesterol biosynthetic process", "Regulation of cholesterol efflux", "Regulation of cholesterol esterification", "Regulation of cholesterol metabolic process", "Regulation of chondrocyte differentiation", "Regulation of chromatin assembly", "Regulation of chromatin assembly or disassembly", "Regulation of chromatin binding", "Regulation of chromatin organization", "Regulation of chromosome condensation", "Regulation of chromosome organization", "Regulation of chromosome segregation", "Regulation of chromosome separation", "Regulation of cilium assembly", "Regulation of cilium beat frequency", "Regulation of cilium beat frequency involved in ciliary motility", "Regulation of cilium dependent cell motility", "Regulation of cilium movement", "Regulation of circadian rhythm", "Regulation of clathrin dependent endocytosis", "Regulation of coagulation", "Regulation of collagen fibril organization", "Regulation of collagen metabolic process", "Regulation of collateral sprouting", "Regulation of complement activation", "Regulation of complement dependent cytotoxicity", "Regulation of connective tissue replacement", "Regulation of core promoter binding", "Regulation of cyclase activity", "Regulation of cyclic nucleotide phosphodiesterase activity", "Regulation of cyclin dependent protein kinase activity", "Regulation of cysteine type endopeptidase activity", "Regulation of cysteine type endopeptidase activity involved in apoptotic signaling pathway", "Regulation of cysteine type endopeptidase activity involved in execution phase of apoptosis", "Regulation of cytokinesis", "Regulation of cytoplasmic mrna processing body assembly", "Regulation of cytoplasmic translation", "Regulation of cytoplasmic translational elongation", "Regulation of cytoplasmic translational initiation", "Regulation of cytoplasmic transport", "Regulation of cytoskeleton organization", "Regulation of cytosolic calcium ion concentration", "Regulation of deacetylase activity", "Regulation of defense response", "Regulation of defense response to virus", "Regulation of defense response to virus by host", "Regulation of dendrite development", "Regulation of dendrite extension", "Regulation of dendrite morphogenesis", "Regulation of dendritic cell chemotaxis", "Regulation of dendritic cell differentiation", "Regulation of dendritic spine development", "Regulation of dendritic spine maintenance", "Regulation of dendritic spine morphogenesis", "Regulation of deoxyribonuclease activity", "Regulation of dephosphorylation", "Regulation of developmental growth", "Regulation of digestive system process", "Regulation of dna binding", "Regulation of dna binding transcription factor activity", "Regulation of dna biosynthetic process", "Regulation of dna catabolic process", "Regulation of dna damage checkpoint", "Regulation of dna damage response signal transduction by p53 class mediator", "Regulation of dna damage response signal transduction by p53 class mediator resulting in transcription of p21 class mediator", "Regulation of dna demethylation", "Regulation of dna dependent dna replication", "Regulation of dna dependent dna replication initiation", "Regulation of dna directed dna polymerase activity", "Regulation of dna duplex unwinding", "Regulation of dna helicase activity", "Regulation of dna ligation", "Regulation of dna metabolic process", "Regulation of dna methylation", "Regulation of dna methylation dependent heterochromatin assembly", "Regulation of dna primase activity", "Regulation of dna recombination", "Regulation of dna repair", "Regulation of dna replication", "Regulation of dna strand elongation", "Regulation of dna templated transcription elongation", "Regulation of dna templated transcription in response to stress", "Regulation of dna templated transcription initiation", "Regulation of dna topoisomerase atp hydrolyzing activity", "Regulation of dopamine receptor signaling pathway", "Regulation of double strand break repair", "Regulation of double strand break repair via homologous recombination", "Regulation of double strand break repair via nonhomologous end joining", "Regulation of early endosome to late endosome transport", "Regulation of electron transfer activity", "Regulation of embryonic development", "Regulation of endocrine process", "Regulation of endocytic recycling", "Regulation of endocytosis", "Regulation of endodeoxyribonuclease activity", "Regulation of endodermal cell differentiation", "Regulation of endoplasmic reticulum stress induced intrinsic apoptotic signaling pathway", "Regulation of endoplasmic reticulum tubular network organization", "Regulation of endoplasmic reticulum unfolded protein response", "Regulation of endosome to plasma membrane protein transport", "Regulation of endothelial cell chemotaxis", "Regulation of endothelial cell development", "Regulation of endothelial cell differentiation", "Regulation of endothelial cell migration", "Regulation of entry of bacterium into host cell", "Regulation of epidermal growth factor activated receptor activity", "Regulation of epidermis development", "Regulation of epithelial cell apoptotic process", "Regulation of epithelial cell differentiation", "Regulation of epithelial cell differentiation involved in kidney development", "Regulation of epithelial cell migration", "Regulation of epithelial cell proliferation involved in lung morphogenesis", "Regulation of epithelial to mesenchymal transition", "Regulation of er associated ubiquitin dependent protein catabolic process", "Regulation of er to golgi vesicle mediated transport", "Regulation of erad pathway", "Regulation of erbb signaling pathway", "Regulation of erythrocyte differentiation", "Regulation of establishment of planar polarity", "Regulation of establishment of protein localization", "Regulation of establishment of protein localization to chromosome", "Regulation of establishment of protein localization to mitochondrion", "Regulation of establishment or maintenance of cell polarity", "Regulation of excretion", "Regulation of execution phase of apoptosis", "Regulation of exit from mitosis", "Regulation of exocytosis", "Regulation of exosomal secretion", "Regulation of extent of cell growth", "Regulation of extracellular matrix assembly", "Regulation of extracellular matrix disassembly", "Regulation of extracellular matrix organization", "Regulation of extrinsic apoptotic signaling pathway", "Regulation of extrinsic apoptotic signaling pathway in absence of ligand", "Regulation of extrinsic apoptotic signaling pathway via death domain receptors", "Regulation of fat cell differentiation", "Regulation of fat cell proliferation", "Regulation of fatty acid beta oxidation", "Regulation of fatty acid biosynthetic process", "Regulation of fatty acid metabolic process", "Regulation of fatty acid oxidation", "Regulation of fatty acid transport", "Regulation of fc gamma receptor signaling pathway involved in phagocytosis", "Regulation of fc receptor mediated stimulatory signaling pathway", "Regulation of feeding behavior", "Regulation of fertilization", "Regulation of fibroblast growth factor receptor signaling pathway", "Regulation of fibroblast migration", "Regulation of filopodium assembly", "Regulation of focal adhesion disassembly", "Regulation of g protein coupled receptor signaling pathway", "Regulation of g0 to g1 transition", "Regulation of gamma aminobutyric acid secretion", "Regulation of gastrulation", "Regulation of gene expression by genomic imprinting", "Regulation of gene expression epigenetic", "Regulation of gene silencing by rna", "Regulation of generation of precursor metabolites and energy", "Regulation of genetic imprinting", "Regulation of germ cell proliferation", "Regulation of germinal center formation", "Regulation of glial cell apoptotic process", "Regulation of glial cell differentiation", "Regulation of glial cell migration", "Regulation of glial cell proliferation", "Regulation of gliogenesis", "Regulation of glucagon secretion", "Regulation of glucan biosynthetic process", "Regulation of glucocorticoid biosynthetic process", "Regulation of glucocorticoid metabolic process", "Regulation of glucocorticoid receptor signaling pathway", "Regulation of glucocorticoid secretion", "Regulation of gluconeogenesis", "Regulation of glucose import", "Regulation of glucose metabolic process", "Regulation of glucose transmembrane transport", "Regulation of glucosylceramidase activity", "Regulation of glutamate secretion", "Regulation of glycogen catabolic process", "Regulation of glycogen metabolic process", "Regulation of glycolytic process", "Regulation of glycoprotein metabolic process", "Regulation of golgi organization", "Regulation of golgi to plasma membrane protein transport", "Regulation of gonad development", "Regulation of granulocyte chemotaxis", "Regulation of growth", "Regulation of gtp binding", "Regulation of gtpase activity", "Regulation of guanyl nucleotide exchange factor activity", "Regulation of hair cycle", "Regulation of hair follicle development", "Regulation of heart contraction", "Regulation of heart growth", "Regulation of heart rate", "Regulation of heart rate by cardiac conduction", "Regulation of heart rate by chemical signal", "Regulation of helicase activity", "Regulation of hematopoietic progenitor cell differentiation", "Regulation of hematopoietic stem cell differentiation", "Regulation of hematopoietic stem cell proliferation", "Regulation of hemoglobin biosynthetic process", "Regulation of hemopoiesis", "Regulation of hepatic stellate cell activation", "Regulation of heterotypic cell cell adhesion", "Regulation of hexokinase activity", "Regulation of high voltage gated calcium channel activity", "Regulation of hippo signaling", "Regulation of histamine secretion by mast cell", "Regulation of histone deacetylase activity", "Regulation of histone deacetylation", "Regulation of histone h2b ubiquitination", "Regulation of histone h3 k14 acetylation", "Regulation of histone h3 k27 methylation", "Regulation of histone h3 k4 methylation", "Regulation of histone h3 k9 methylation", "Regulation of histone h3 k9 trimethylation", "Regulation of histone h4 acetylation", "Regulation of histone h4 k16 acetylation", "Regulation of histone methylation", "Regulation of histone modification", "Regulation of histone phosphorylation", "Regulation of histone ubiquitination", "Regulation of homotypic cell cell adhesion", "Regulation of hormone biosynthetic process", "Regulation of hormone levels", "Regulation of hormone metabolic process", "Regulation of hormone secretion", "Regulation of humoral immune response", "Regulation of hyaluronan biosynthetic process", "Regulation of hydrogen peroxide biosynthetic process", "Regulation of hydrogen peroxide mediated programmed cell death", "Regulation of hydrogen peroxide metabolic process", "Regulation of hydrolase activity", "Regulation of i kappab phosphorylation", "Regulation of icosanoid secretion", "Regulation of immune effector process", "Regulation of immune response", "Regulation of immune system process", "Regulation of immunoglobulin production", "Regulation of inclusion body assembly", "Regulation of inflammatory response", "Regulation of inflammatory response to antigenic stimulus", "Regulation of innate immune response", "Regulation of inositol 1 4 5 trisphosphate sensitive calcium release channel activity", "Regulation of insulin like growth factor receptor signaling pathway", "Regulation of insulin receptor signaling pathway", "Regulation of insulin secretion", "Regulation of insulin secretion involved in cellular response to glucose stimulus", "Regulation of integrin activation", "Regulation of integrin mediated signaling pathway", "Regulation of interleukin 1 mediated signaling pathway", "Regulation of intestinal absorption", "Regulation of intestinal lipid absorption", "Regulation of intracellular estrogen receptor signaling pathway", "Regulation of intracellular lipid transport", "Regulation of intracellular protein transport", "Regulation of intracellular signal transduction", "Regulation of intracellular steroid hormone receptor signaling pathway", "Regulation of intracellular transport", "Regulation of intrinsic apoptotic signaling pathway", "Regulation of intrinsic apoptotic signaling pathway by p53 class mediator", "Regulation of intrinsic apoptotic signaling pathway in response to dna damage", "Regulation of intrinsic apoptotic signaling pathway in response to dna damage by p53 class mediator", "Regulation of intrinsic apoptotic signaling pathway in response to osmotic stress", "Regulation of inward rectifier potassium channel activity", "Regulation of ion transmembrane transport", "Regulation of ion transport", "Regulation of ire1 mediated unfolded protein response", "Regulation of isomerase activity", "Regulation of isotype switching", "Regulation of jnk cascade", "Regulation of jun kinase activity", "Regulation of keratinocyte differentiation", "Regulation of keratinocyte migration", "Regulation of keratinocyte proliferation", "Regulation of kidney development", "Regulation of l glutamate import across plasma membrane", "Regulation of lamellipodium assembly", "Regulation of lamellipodium morphogenesis", "Regulation of lamellipodium organization", "Regulation of leukocyte apoptotic process", "Regulation of leukocyte chemotaxis", "Regulation of leukocyte degranulation", "Regulation of leukocyte differentiation", "Regulation of leukocyte mediated cytotoxicity", "Regulation of leukocyte mediated immunity", "Regulation of leukocyte migration", "Regulation of leukocyte proliferation", "Regulation of ligase activity", "Regulation of lipase activity", "Regulation of lipid biosynthetic process", "Regulation of lipid catabolic process", "Regulation of lipid kinase activity", "Regulation of lipid localization", "Regulation of lipid metabolic process", "Regulation of lipid storage", "Regulation of lipid transport", "Regulation of lipophagy", "Regulation of lipopolysaccharide mediated signaling pathway", "Regulation of lipoprotein metabolic process", "Regulation of lipoprotein particle clearance", "Regulation of locomotion involved in locomotory behavior", "Regulation of long chain fatty acid import across plasma membrane", "Regulation of long chain fatty acid import into cell", "Regulation of long term neuronal synaptic plasticity", "Regulation of long term synaptic depression", "Regulation of long term synaptic potentiation", "Regulation of low density lipoprotein particle clearance", "Regulation of lyase activity", "Regulation of lymphocyte activation", "Regulation of lymphocyte apoptotic process", "Regulation of lymphocyte chemotaxis", "Regulation of lymphocyte differentiation", "Regulation of lymphocyte mediated immunity", "Regulation of lymphocyte migration", "Regulation of lymphoid progenitor cell differentiation", "Regulation of lysosomal lumen ph", "Regulation of lysosomal protein catabolic process", "Regulation of lysosome organization", "Regulation of macroautophagy", "Regulation of macrophage activation", "Regulation of macrophage apoptotic process", "Regulation of macrophage chemotaxis", "Regulation of macrophage migration", "Regulation of macrophage proliferation", "Regulation of maintenance of sister chromatid cohesion", "Regulation of male gonad development", "Regulation of mammary gland epithelial cell proliferation", "Regulation of map kinase activity", "Regulation of mast cell activation", "Regulation of mast cell activation involved in immune response", "Regulation of mda 5 signaling pathway", "Regulation of megakaryocyte differentiation", "Regulation of meiotic cell cycle", "Regulation of meiotic cell cycle phase transition", "Regulation of meiotic nuclear division", "Regulation of membrane depolarization", "Regulation of membrane invagination", "Regulation of membrane lipid distribution", "Regulation of membrane permeability", "Regulation of membrane potential", "Regulation of membrane protein ectodomain proteolysis", "Regulation of membrane repolarization", "Regulation of membrane repolarization during action potential", "Regulation of membrane repolarization during cardiac muscle cell action potential", "Regulation of membrane tubulation", "Regulation of mesenchymal cell proliferation", "Regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis", "Regulation of mesoderm development", "Regulation of metal ion transport", "Regulation of metalloendopeptidase activity", "Regulation of metallopeptidase activity", "Regulation of metanephros development", "Regulation of metaphase plate congression", "Regulation of microglial cell activation", "Regulation of microtubule based movement", "Regulation of microtubule based process", "Regulation of microtubule binding", "Regulation of microtubule cytoskeleton organization", "Regulation of microtubule depolymerization", "Regulation of microtubule nucleation", "Regulation of microtubule polymerization", "Regulation of microtubule polymerization or depolymerization", "Regulation of microvillus assembly", "Regulation of microvillus length", "Regulation of microvillus organization", "Regulation of mirna catabolic process", "Regulation of mirna metabolic process", "Regulation of mirna transcription", "Regulation of mitochondrial atp synthesis coupled electron transport", "Regulation of mitochondrial dna replication", "Regulation of mitochondrial electron transport nadh to ubiquinone", "Regulation of mitochondrial fission", "Regulation of mitochondrial fusion", "Regulation of mitochondrial gene expression", "Regulation of mitochondrial membrane permeability", "Regulation of mitochondrial membrane permeability involved in apoptotic process", "Regulation of mitochondrial membrane potential", "Regulation of mitochondrial mrna stability", "Regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway", "Regulation of mitochondrial rna catabolic process", "Regulation of mitochondrion organization", "Regulation of mitophagy", "Regulation of mitotic cell cycle", "Regulation of mitotic cell cycle phase transition", "Regulation of mitotic cell cycle spindle assembly checkpoint", "Regulation of mitotic centrosome separation", "Regulation of mitotic cytokinesis", "Regulation of mitotic nuclear division", "Regulation of mitotic recombination", "Regulation of mitotic sister chromatid segregation", "Regulation of mitotic spindle assembly", "Regulation of modification of postsynaptic structure", "Regulation of modification of synaptic structure", "Regulation of monocyte chemotaxis", "Regulation of monocyte differentiation", "Regulation of monocyte extravasation", "Regulation of mononuclear cell migration", "Regulation of monooxygenase activity", "Regulation of morphogenesis of a branching structure", "Regulation of morphogenesis of an epithelium", "Regulation of motor neuron apoptotic process", "Regulation of mrna 3 end processing", "Regulation of mrna binding", "Regulation of mrna catabolic process", "Regulation of mrna export from nucleus", "Regulation of mrna metabolic process", "Regulation of mrna polyadenylation", "Regulation of mrna processing", "Regulation of mrna splicing via spliceosome", "Regulation of multicellular organism growth", "Regulation of multicellular organismal development", "Regulation of muscle adaptation", "Regulation of muscle cell differentiation", "Regulation of muscle contraction", "Regulation of muscle hypertrophy", "Regulation of muscle organ development", "Regulation of muscle system process", "Regulation of myelination", "Regulation of myeloid cell apoptotic process", "Regulation of myeloid cell differentiation", "Regulation of myeloid leukocyte differentiation", "Regulation of myeloid leukocyte mediated immunity", "Regulation of myoblast differentiation", "Regulation of myoblast fusion", "Regulation of myosin light chain phosphatase activity", "Regulation of myotube differentiation", "Regulation of nad p h oxidase activity", "Regulation of nadp metabolic process", "Regulation of natural killer cell activation", "Regulation of natural killer cell mediated immunity", "Regulation of necrotic cell death", "Regulation of nervous system development", "Regulation of nervous system process", "Regulation of neural precursor cell proliferation", "Regulation of neuroblast proliferation", "Regulation of neurogenesis", "Regulation of neuromuscular junction development", "Regulation of neuron differentiation", "Regulation of neuron migration", "Regulation of neuron projection arborization", "Regulation of neuron projection development", "Regulation of neuron projection regeneration", "Regulation of neuronal action potential", "Regulation of neuronal synaptic plasticity", "Regulation of neurotransmitter levels", "Regulation of neurotransmitter receptor activity", "Regulation of neurotransmitter receptor localization to postsynaptic specialization membrane", "Regulation of neurotransmitter transport", "Regulation of neurotransmitter uptake", "Regulation of neurotrophin trk receptor signaling pathway", "Regulation of neutrophil chemotaxis", "Regulation of neutrophil migration", "Regulation of nik nf kappab signaling", "Regulation of nitric oxide metabolic process", "Regulation of nitric oxide synthase activity", "Regulation of nk t cell activation", "Regulation of nk t cell differentiation", "Regulation of nmda receptor activity", "Regulation of non motile cilium assembly", "Regulation of notch signaling pathway", "Regulation of nuclear cell cycle dna replication", "Regulation of nuclear division", "Regulation of nuclear transcribed mrna catabolic process deadenylation dependent decay", "Regulation of nuclear transcribed mrna catabolic process nonsense mediated decay", "Regulation of nuclear transcribed mrna poly a tail shortening", "Regulation of nuclease activity", "Regulation of nucleobase containing compound transport", "Regulation of nucleocytoplasmic transport", "Regulation of nucleotide binding oligomerization domain containing 2 signaling pathway", "Regulation of nucleotide binding oligomerization domain containing signaling pathway", "Regulation of nucleotide biosynthetic process", "Regulation of nucleotide metabolic process", "Regulation of oligodendrocyte differentiation", "Regulation of oocyte maturation", "Regulation of organ growth", "Regulation of organelle assembly", "Regulation of organelle organization", "Regulation of organelle transport along microtubule", "Regulation of organic acid transport", "Regulation of ossification", "Regulation of osteoblast differentiation", "Regulation of osteoblast proliferation", "Regulation of osteoclast differentiation", "Regulation of oxidative phosphorylation", "Regulation of oxidative stress induced cell death", "Regulation of oxidative stress induced intrinsic apoptotic signaling pathway", "Regulation of oxidoreductase activity", "Regulation of p38mapk cascade", "Regulation of pattern recognition receptor signaling pathway", "Regulation of peptidase activity", "Regulation of peptide transport", "Regulation of peptidyl lysine acetylation", "Regulation of peptidyl serine phosphorylation", "Regulation of peptidyl serine phosphorylation of stat protein", "Regulation of peptidyl threonine phosphorylation", "Regulation of peptidyl tyrosine phosphorylation", "Regulation of perk mediated unfolded protein response", "Regulation of peroxisome proliferator activated receptor signaling pathway", "Regulation of ph", "Regulation of phagocytosis", "Regulation of phenotypic switching", "Regulation of phosphatase activity", "Regulation of phosphatidylcholine biosynthetic process", "Regulation of phosphatidylcholine metabolic process", "Regulation of phosphatidylinositol 3 kinase activity", "Regulation of phosphatidylinositol 3 kinase signaling", "Regulation of phosphatidylinositol dephosphorylation", "Regulation of phospholipase a2 activity", "Regulation of phospholipase activity", "Regulation of phospholipase c activity", "Regulation of phospholipid biosynthetic process", "Regulation of phospholipid catabolic process", "Regulation of phospholipid metabolic process", "Regulation of phospholipid translocation", "Regulation of phospholipid transport", "Regulation of phosphoprotein phosphatase activity", "Regulation of phosphorus metabolic process", "Regulation of pigmentation", "Regulation of pinocytosis", "Regulation of plasma lipoprotein particle levels", "Regulation of plasma membrane organization", "Regulation of plasminogen activation", "Regulation of platelet activation", "Regulation of platelet aggregation", "Regulation of platelet derived growth factor receptor beta signaling pathway", "Regulation of platelet derived growth factor receptor signaling pathway", "Regulation of podosome assembly", "Regulation of polysaccharide metabolic process", "Regulation of post translational protein modification", "Regulation of postsynapse organization", "Regulation of postsynaptic density organization", "Regulation of postsynaptic membrane neurotransmitter receptor levels", "Regulation of postsynaptic membrane potential", "Regulation of postsynaptic neurotransmitter receptor internalization", "Regulation of potassium ion export across plasma membrane", "Regulation of potassium ion import", "Regulation of potassium ion transmembrane transporter activity", "Regulation of potassium ion transport", "Regulation of presynapse organization", "Regulation of presynaptic cytosolic calcium ion concentration", "Regulation of pro b cell differentiation", "Regulation of production of molecular mediator of immune response", "Regulation of production of small rna involved in gene silencing by rna", "Regulation of programmed necrotic cell death", "Regulation of prostaglandin secretion", "Regulation of proteasomal protein catabolic process", "Regulation of proteasomal ubiquitin dependent protein catabolic process", "Regulation of protein acetylation", "Regulation of protein adp ribosylation", "Regulation of protein autophosphorylation", "Regulation of protein autoubiquitination", "Regulation of protein binding", "Regulation of protein catabolic process", "Regulation of protein catabolic process in the vacuole", "Regulation of protein complex stability", "Regulation of protein containing complex assembly", "Regulation of protein containing complex disassembly", "Regulation of protein deacetylation", "Regulation of protein dephosphorylation", "Regulation of protein depolymerization", "Regulation of protein deubiquitination", "Regulation of protein exit from endoplasmic reticulum", "Regulation of protein export from nucleus", "Regulation of protein folding", "Regulation of protein glycosylation", "Regulation of protein import", "Regulation of protein k63 linked ubiquitination", "Regulation of protein kinase a signaling", "Regulation of protein kinase activity", "Regulation of protein kinase c signaling", "Regulation of protein lipidation", "Regulation of protein localization", "Regulation of protein localization to cell cortex", "Regulation of protein localization to cell periphery", "Regulation of protein localization to cell surface", "Regulation of protein localization to centrosome", "Regulation of protein localization to chromatin", "Regulation of protein localization to chromosome telomeric region", "Regulation of protein localization to cilium", "Regulation of protein localization to endosome", "Regulation of protein localization to membrane", "Regulation of protein localization to nucleolus", "Regulation of protein localization to nucleus", "Regulation of protein localization to plasma membrane", "Regulation of protein localization to synapse", "Regulation of protein maturation", "Regulation of protein modification by small protein conjugation or removal", "Regulation of protein modification process", "Regulation of protein monoubiquitination", "Regulation of protein neddylation", "Regulation of protein phosphorylation", "Regulation of protein polymerization", "Regulation of protein polyubiquitination", "Regulation of protein secretion", "Regulation of protein serine threonine kinase activity", "Regulation of protein stability", "Regulation of protein sumoylation", "Regulation of protein targeting", "Regulation of protein targeting to membrane", "Regulation of protein tyrosine kinase activity", "Regulation of protein tyrosine phosphatase activity", "Regulation of proteolysis", "Regulation of proton transport", "Regulation of rac protein signal transduction", "Regulation of ras protein signal transduction", "Regulation of reactive oxygen species biosynthetic process", "Regulation of reactive oxygen species metabolic process", "Regulation of receptor binding", "Regulation of receptor catabolic process", "Regulation of receptor clustering", "Regulation of receptor internalization", "Regulation of receptor localization to synapse", "Regulation of receptor mediated endocytosis", "Regulation of receptor mediated endocytosis involved in cholesterol transport", "Regulation of receptor recycling", "Regulation of receptor signaling pathway via stat", "Regulation of regulated secretory pathway", "Regulation of relaxation of muscle", "Regulation of release of cytochrome c from mitochondria", "Regulation of release of sequestered calcium ion into cytosol", "Regulation of removal of superoxide radicals", "Regulation of renal system process", "Regulation of reproductive process", "Regulation of respiratory burst", "Regulation of respiratory gaseous exchange", "Regulation of respiratory gaseous exchange by nervous system process", "Regulation of respiratory system process", "Regulation of response to biotic stimulus", "Regulation of response to cytokine stimulus", "Regulation of response to dna damage stimulus", "Regulation of response to endoplasmic reticulum stress", "Regulation of response to external stimulus", "Regulation of response to extracellular stimulus", "Regulation of response to food", "Regulation of response to interferon gamma", "Regulation of response to osmotic stress", "Regulation of response to oxidative stress", "Regulation of response to reactive oxygen species", "Regulation of response to stress", "Regulation of response to tumor cell", "Regulation of response to wounding", "Regulation of retinal ganglion cell axon guidance", "Regulation of retinoic acid receptor signaling pathway", "Regulation of retrograde protein transport er to cytosol", "Regulation of retrograde transport endosome to golgi", "Regulation of rho dependent protein serine threonine kinase activity", "Regulation of rho protein signal transduction", "Regulation of rhodopsin mediated signaling pathway", "Regulation of ribonuclease activity", "Regulation of ribosome biogenesis", "Regulation of rig i signaling pathway", "Regulation of rna binding", "Regulation of rna export from nucleus", "Regulation of rna polymerase ii regulatory region sequence specific dna binding", "Regulation of rna polymerase ii transcription preinitiation complex assembly", "Regulation of rna splicing", "Regulation of rrna processing", "Regulation of ruffle assembly", "Regulation of ryanodine sensitive calcium release channel activity", "Regulation of sarcomere organization", "Regulation of secondary heart field cardioblast proliferation", "Regulation of secondary metabolic process", "Regulation of secretion", "Regulation of sensory perception", "Regulation of sequestering of triglyceride", "Regulation of sequestering of zinc ion", "Regulation of short term neuronal synaptic plasticity", "Regulation of signal transduction by p53 class mediator", "Regulation of signaling receptor activity", "Regulation of sister chromatid cohesion", "Regulation of skeletal muscle adaptation", "Regulation of skeletal muscle cell differentiation", "Regulation of skeletal muscle contraction", "Regulation of skeletal muscle contraction by calcium ion signaling", "Regulation of skeletal muscle fiber development", "Regulation of skeletal muscle tissue development", "Regulation of smad protein complex assembly", "Regulation of smad protein signal transduction", "Regulation of small gtpase mediated signal transduction", "Regulation of small molecule metabolic process", "Regulation of smooth muscle cell chemotaxis", "Regulation of smooth muscle cell differentiation", "Regulation of smooth muscle contraction", "Regulation of smoothened signaling pathway", "Regulation of smoothened signaling pathway involved in dorsal ventral neural tube patterning", "Regulation of snrna transcription by rna polymerase ii", "Regulation of sodium ion transmembrane transport", "Regulation of sodium ion transport", "Regulation of sodium proton antiporter activity", "Regulation of somatic stem cell population maintenance", "Regulation of sphingolipid biosynthetic process", "Regulation of spindle assembly", "Regulation of spindle organization", "Regulation of spontaneous synaptic transmission", "Regulation of sprouting angiogenesis", "Regulation of srebp signaling pathway", "Regulation of stem cell differentiation", "Regulation of stem cell population maintenance", "Regulation of stem cell proliferation", "Regulation of steroid biosynthetic process", "Regulation of steroid hormone biosynthetic process", "Regulation of steroid hormone secretion", "Regulation of steroid metabolic process", "Regulation of sterol transport", "Regulation of store operated calcium channel activity", "Regulation of store operated calcium entry", "Regulation of stress activated protein kinase signaling cascade", "Regulation of stress granule assembly", "Regulation of striated muscle cell differentiation", "Regulation of striated muscle contraction", "Regulation of substrate adhesion dependent cell spreading", "Regulation of sulfur metabolic process", "Regulation of superoxide anion generation", "Regulation of superoxide dismutase activity", "Regulation of superoxide metabolic process", "Regulation of supramolecular fiber organization", "Regulation of synapse assembly", "Regulation of synapse maturation", "Regulation of synapse structural plasticity", "Regulation of synapse structure or activity", "Regulation of synaptic plasticity", "Regulation of synaptic transmission dopaminergic", "Regulation of synaptic transmission gabaergic", "Regulation of synaptic transmission glutamatergic", "Regulation of synaptic vesicle clustering", "Regulation of synaptic vesicle endocytosis", "Regulation of synaptic vesicle exocytosis", "Regulation of synaptic vesicle priming", "Regulation of synaptic vesicle recycling", "Regulation of syncytium formation by plasma membrane fusion", "Regulation of system process", "Regulation of systemic arterial blood pressure", "Regulation of systemic arterial blood pressure by circulatory renin angiotensin", "Regulation of systemic arterial blood pressure by endothelin", "Regulation of systemic arterial blood pressure by hormone", "Regulation of systemic arterial blood pressure by norepinephrine epinephrine", "Regulation of systemic arterial blood pressure by renin angiotensin", "Regulation of systemic arterial blood pressure mediated by a chemical signal", "Regulation of t cell activation", "Regulation of t cell apoptotic process", "Regulation of t cell chemotaxis", "Regulation of t cell differentiation", "Regulation of t cell differentiation in thymus", "Regulation of t cell mediated cytotoxicity", "Regulation of t cell mediated immune response to tumor cell", "Regulation of t cell mediated immunity", "Regulation of t cell migration", "Regulation of t cell proliferation", "Regulation of t cell receptor signaling pathway", "Regulation of t circle formation", "Regulation of t helper 1 cell differentiation", "Regulation of t helper 1 type immune response", "Regulation of t helper 2 cell differentiation", "Regulation of t helper cell differentiation", "Regulation of tau protein kinase activity", "Regulation of telomerase activity", "Regulation of telomere capping", "Regulation of telomere maintenance", "Regulation of telomere maintenance via telomere lengthening", "Regulation of tetrapyrrole metabolic process", "Regulation of the force of heart contraction", "Regulation of thymocyte apoptotic process", "Regulation of tissue remodeling", "Regulation of tolerance induction", "Regulation of toll like receptor 3 signaling pathway", "Regulation of toll like receptor 4 signaling pathway", "Regulation of toll like receptor 7 signaling pathway", "Regulation of toll like receptor 9 signaling pathway", "Regulation of toll like receptor signaling pathway", "Regulation of tor signaling", "Regulation of torc2 signaling", "Regulation of trail activated apoptotic signaling pathway", "Regulation of trans synaptic signaling", "Regulation of transcription by glucose", "Regulation of transcription by rna polymerase i", "Regulation of transcription by rna polymerase iii", "Regulation of transcription elongation from rna polymerase ii promoter", "Regulation of transcription from rna polymerase ii promoter in response to hypoxia", "Regulation of transcription from rna polymerase ii promoter in response to oxidative stress", "Regulation of transcription involved in g1 s transition of mitotic cell cycle", "Regulation of transcription of nucleolar large rrna by rna polymerase i", "Regulation of transcription regulatory region dna binding", "Regulation of transferase activity", "Regulation of transforming growth factor beta activation", "Regulation of transforming growth factor beta1 production", "Regulation of translation at synapse modulating synaptic transmission", "Regulation of translation in response to endoplasmic reticulum stress", "Regulation of translation in response to stress", "Regulation of translation initiation in response to endoplasmic reticulum stress", "Regulation of translational elongation", "Regulation of translational fidelity", "Regulation of translational initiation", "Regulation of translational initiation by eif2 alpha phosphorylation", "Regulation of translational initiation in response to stress", "Regulation of translational termination", "Regulation of transmembrane receptor protein serine threonine kinase signaling pathway", "Regulation of transmembrane transport", "Regulation of transmission of nerve impulse", "Regulation of transport", "Regulation of transporter activity", "Regulation of transposition", "Regulation of triglyceride biosynthetic process", "Regulation of triglyceride metabolic process", "Regulation of tube size", "Regulation of tumor necrosis factor mediated signaling pathway", "Regulation of type b pancreatic cell development", "Regulation of type i interferon mediated signaling pathway", "Regulation of ubiquitin dependent protein catabolic process", "Regulation of ubiquitin protein ligase activity", "Regulation of ubiquitin protein transferase activity", "Regulation of ubiquitin specific protease activity", "Regulation of unsaturated fatty acid biosynthetic process", "Regulation of urine volume", "Regulation of vacuole organization", "Regulation of vascular associated smooth muscle cell differentiation", "Regulation of vascular associated smooth muscle contraction", "Regulation of vascular endothelial growth factor receptor signaling pathway", "Regulation of vascular permeability", "Regulation of vasculature development", "Regulation of vasculogenesis", "Regulation of vasoconstriction", "Regulation of ventricular cardiac muscle cell action potential", "Regulation of very low density lipoprotein particle clearance", "Regulation of vesicle fusion", "Regulation of vesicle mediated transport", "Regulation of vesicle size", "Regulation of viral entry into host cell", "Regulation of viral genome replication", "Regulation of viral induced cytoplasmic pattern recognition receptor signaling pathway", "Regulation of viral process", "Regulation of viral transcription", "Regulation of vitamin d receptor signaling pathway", "Regulation of vitamin metabolic process", "Regulation of voltage gated calcium channel activity", "Regulation of water loss via skin", "Regulation of wnt signaling pathway", "Regulation of wound healing", "Regulation of wound healing spreading of epidermal cells", "Regulatory t cell differentiation", "Relaxation of cardiac muscle", "Relaxation of muscle", "Release of cytochrome c from mitochondria", "Release of sequestered calcium ion into cytosol by endoplasmic reticulum", "Renal absorption", "Renal filtration", "Renal sodium excretion", "Renal sodium ion absorption", "Renal sodium ion transport", "Renal system process", "Renal system vasculature development", "Renal tubular secretion", "Renal tubule development", "Renal vesicle development", "Renal vesicle formation", "Renal water homeostasis", "Replacement ossification", "Replication born double strand break repair via sister chromatid exchange", "Replication fork processing", "Replication fork protection", "Replicative senescence", "Reproduction", "Reproductive behavior", "Reproductive system development", "Rescue of stalled ribosome", "Resolution of meiotic recombination intermediates", "Respiratory burst", "Respiratory burst involved in defense response", "Respiratory burst involved in inflammatory response", "Respiratory chain complex iii assembly", "Respiratory chain complex iv assembly", "Respiratory electron transport chain", "Respiratory gaseous exchange by respiratory system", "Respiratory system development", "Respiratory system process", "Response to abiotic stimulus", "Response to acetylcholine", "Response to acid chemical", "Response to acidic ph", "Response to actinomycin d", "Response to activity", "Response to alcohol", "Response to aldosterone", "Response to alkaloid", "Response to amine", "Response to amino acid starvation", "Response to ammonium ion", "Response to amphetamine", "Response to amyloid beta", "Response to angiotensin", "Response to antibiotic", "Response to arsenic containing substance", "Response to arsenite ion", "Response to atp", "Response to auditory stimulus", "Response to axon injury", "Response to bacterium", "Response to bmp", "Response to cadmium ion", "Response to caffeine", "Response to calcium ion", "Response to camp", "Response to carbohydrate", "Response to catecholamine", "Response to cell cycle checkpoint signaling", "Response to cgmp", "Response to chemokine", "Response to cholesterol", "Response to cisplatin", "Response to cobalt ion", "Response to cocaine", "Response to cold", "Response to copper ion", "Response to corticosteroid", "Response to corticosterone", "Response to cortisol", "Response to cytokine", "Response to dexamethasone", "Response to dietary excess", "Response to dopamine", "Response to dsrna", "Response to electrical stimulus", "Response to endogenous stimulus", "Response to endoplasmic reticulum stress", "Response to epidermal growth factor", "Response to epinephrine", "Response to estradiol", "Response to estrogen", "Response to ethanol", "Response to ether", "Response to extracellular stimulus", "Response to fatty acid", "Response to fibroblast growth factor", "Response to fluid shear stress", "Response to folic acid", "Response to follicle stimulating hormone", "Response to food", "Response to fungus", "Response to gamma radiation", "Response to glucagon", "Response to glycoprotein", "Response to glycoside", "Response to gonadotropin", "Response to granulocyte macrophage colony stimulating factor", "Response to growth factor", "Response to growth hormone", "Response to heat", "Response to heparin", "Response to hepatocyte growth factor", "Response to herbicide", "Response to histamine", "Response to hormone", "Response to human chorionic gonadotropin", "Response to hydrogen peroxide", "Response to hydroperoxide", "Response to hydrostatic pressure", "Response to hydroxyurea", "Response to hyperoxia", "Response to immobilization stress", "Response to inactivity", "Response to increased oxygen levels", "Response to indole 3 methanol", "Response to inorganic substance", "Response to insecticide", "Response to insulin", "Response to interferon alpha", "Response to interferon beta", "Response to interferon gamma", "Response to interleukin 1", "Response to interleukin 12", "Response to interleukin 17", "Response to interleukin 4", "Response to interleukin 6", "Response to interleukin 7", "Response to ionizing radiation", "Response to iron ii ion", "Response to iron ion", "Response to ischemia", "Response to isoquinoline alkaloid", "Response to ketone", "Response to l ascorbic acid", "Response to l glutamate", "Response to l phenylalanine derivative", "Response to lead ion", "Response to lectin", "Response to leptin", "Response to leucine", "Response to leukemia inhibitory factor", "Response to light intensity", "Response to light stimulus", "Response to lipid", "Response to lipoteichoic acid", "Response to lithium ion", "Response to manganese ion", "Response to mechanical stimulus", "Response to mercury ion", "Response to metal ion", "Response to methylmercury", "Response to mineralocorticoid", "Response to misfolded protein", "Response to mitochondrial depolarisation", "Response to molecule of bacterial origin", "Response to monosaccharide", "Response to muramyl dipeptide", "Response to muscle activity", "Response to muscle inactivity", "Response to muscle stretch", "Response to nerve growth factor", "Response to nicotine", "Response to nitric oxide", "Response to nitrogen compound", "Response to nitrosative stress", "Response to nutrient", "Response to oleic acid", "Response to organic cyclic compound", "Response to osmotic stress", "Response to oxidative stress", "Response to oxygen containing compound", "Response to oxygen glucose deprivation", "Response to oxygen levels", "Response to oxygen radical", "Response to pain", "Response to parathyroid hormone", "Response to peptide", "Response to peptide hormone", "Response to peptidoglycan", "Response to ph", "Response to phorbol 13 acetate 12 myristate", "Response to platelet derived growth factor", "Response to progesterone", "Response to prostaglandin", "Response to prostaglandin e", "Response to purine containing compound", "Response to radiation", "Response to reactive oxygen species", "Response to redox state", "Response to retinoic acid", "Response to salt", "Response to salt stress", "Response to selenium ion", "Response to sodium arsenite", "Response to sorbitol", "Response to starvation", "Response to steroid hormone", "Response to sterol", "Response to sterol depletion", "Response to stimulus involved in regulation of muscle adaptation", "Response to temperature stimulus", "Response to testosterone", "Response to thyroglobulin triiodothyronine", "Response to thyroid hormone", "Response to thyroxine", "Response to topologically incorrect protein", "Response to toxic substance", "Response to transforming growth factor beta", "Response to tumor cell", "Response to tumor necrosis factor", "Response to type i interferon", "Response to uv", "Response to uv a", "Response to uv b", "Response to uv c", "Response to virus", "Response to vitamin", "Response to vitamin a", "Response to vitamin d", "Response to vitamin k", "Response to water", "Response to wounding", "Response to x ray", "Response to xenobiotic stimulus", "Response to yeast", "Response to zinc ion", "Reticulophagy", "Retina development in camera type eye", "Retina homeostasis", "Retina layer formation", "Retina morphogenesis in camera type eye", "Retina vasculature development in camera type eye", "Retina vasculature morphogenesis in camera type eye", "Retinal cell apoptotic process", "Retinal cone cell differentiation", "Retinal ganglion cell axon guidance", "Retinal metabolic process", "Retinal rod cell development", "Retinal rod cell differentiation", "Retinoic acid metabolic process", "Retinoic acid receptor signaling pathway", "Retinol metabolic process", "Retrograde axonal transport", "Retrograde trans synaptic signaling", "Retrograde trans synaptic signaling by lipid", "Retrograde transport endosome to golgi", "Retrograde transport vesicle recycling within golgi", "Retrograde vesicle mediated transport golgi to endoplasmic reticulum", "Reverse cholesterol transport", "Reversible differentiation", "Rho protein signal transduction", "Rhodopsin mediated signaling pathway", "Rhythmic behavior", "Rhythmic process", "Riboflavin metabolic process", "Ribonucleoprotein complex biogenesis", "Ribonucleoprotein complex disassembly", "Ribonucleoprotein complex localization", "Ribonucleoprotein complex subunit organization", "Ribonucleoside catabolic process", "Ribonucleoside diphosphate biosynthetic process", "Ribonucleoside diphosphate catabolic process", "Ribonucleoside diphosphate metabolic process", "Ribonucleoside metabolic process", "Ribonucleoside monophosphate biosynthetic process", "Ribonucleoside monophosphate catabolic process", "Ribonucleoside monophosphate metabolic process", "Ribonucleoside triphosphate biosynthetic process", "Ribonucleoside triphosphate metabolic process", "Ribonucleotide catabolic process", "Ribose phosphate biosynthetic process", "Ribose phosphate metabolic process", "Ribosomal large subunit assembly", "Ribosomal large subunit biogenesis", "Ribosomal large subunit export from nucleus", "Ribosomal small subunit assembly", "Ribosomal small subunit biogenesis", "Ribosomal small subunit export from nucleus", "Ribosomal subunit export from nucleus", "Ribosome assembly", "Ribosome associated ubiquitin dependent protein catabolic process", "Ribosome biogenesis", "Ribosome disassembly", "Rig i signaling pathway", "Righting reflex", "Rna 3 end processing", "Rna 5 end processing", "Rna capping", "Rna catabolic process", "Rna decapping", "Rna dependent dna biosynthetic process", "Rna destabilization", "Rna export from nucleus", "Rna guanine n7 methylation", "Rna import into mitochondrion", "Rna interference", "Rna localization", "Rna mediated gene silencing by inhibition of translation", "Rna methylation", "Rna modification", "Rna phosphodiester bond hydrolysis", "Rna phosphodiester bond hydrolysis endonucleolytic", "Rna phosphodiester bond hydrolysis exonucleolytic", "Rna polyadenylation", "Rna polymerase i preinitiation complex assembly", "Rna polymerase ii preinitiation complex assembly", "Rna processing", "Rna secondary structure unwinding", "Rna splicing", "Rna splicing via endonucleolytic cleavage and ligation", "Rna splicing via transesterification reactions", "Rna stabilization", "Rna surveillance", "Roof of mouth development", "Rostrocaudal neural tube patterning", "Roundabout signaling pathway", "Rrna 3 end processing", "Rrna 5 end processing", "Rrna base methylation", "Rrna catabolic process", "Rrna metabolic process", "Rrna methylation", "Rrna modification", "Rrna pseudouridine synthesis", "Rrna transcription", "Rrna transport", "Ruffle assembly", "Ruffle organization", "S adenosylmethionine cycle", "S adenosylmethionine metabolic process", "Salivary gland development", "Sarcomere organization", "Sarcoplasmic reticulum calcium ion transport", "Satellite cell activation involved in skeletal muscle regeneration", "Scarna localization to cajal body", "Scf dependent proteasomal ubiquitin dependent protein catabolic process", "Schwann cell development", "Schwann cell differentiation", "Schwann cell proliferation", "Second messenger mediated signaling", "Secondary alcohol metabolic process", "Secondary metabolic process", "Secondary metabolite biosynthetic process", "Secretion", "Secretion by tissue", "Secretion of lysosomal enzymes", "Secretory granule localization", "Secretory granule organization", "Segment specification", "Segmentation", "Selective autophagy", "Self proteolysis", "Semaphorin plexin signaling pathway", "Semaphorin plexin signaling pathway involved in neuron projection guidance", "Semi lunar valve development", "Seminiferous tubule development", "Sensory organ development", "Sensory organ morphogenesis", "Sensory perception", "Sensory perception of light stimulus", "Sensory perception of mechanical stimulus", "Sensory perception of pain", "Sensory system development", "Septum primum development", "Sequestering of actin monomers", "Sequestering of calcium ion", "Sequestering of iron ion", "Sequestering of metal ion", "Sequestering of triglyceride", "Sequestering of zinc ion", "Serine family amino acid biosynthetic process", "Serine family amino acid catabolic process", "Serine family amino acid metabolic process", "Serine phosphorylation of stat protein", "Serine transport", "Serotonin metabolic process", "Sertoli cell development", "Sertoli cell differentiation", "Sex determination", "Sex differentiation", "Short chain fatty acid catabolic process", "Short chain fatty acid metabolic process", "Short term memory", "Signal complex assembly", "Signal peptide processing", "Signal release", "Signal transduction by p53 class mediator", "Signal transduction in absence of ligand", "Signal transduction in response to dna damage", "Signal transduction involved in regulation of gene expression", "Signaling receptor ligand precursor processing", "Single fertilization", "Single strand break repair", "Single stranded viral rna replication via double stranded dna intermediate", "Sister chromatid cohesion", "Sister chromatid segregation", "Skeletal muscle acetylcholine gated channel clustering", "Skeletal muscle adaptation", "Skeletal muscle cell differentiation", "Skeletal muscle cell proliferation", "Skeletal muscle contraction", "Skeletal muscle fiber differentiation", "Skeletal muscle organ development", "Skeletal muscle satellite cell activation", "Skeletal muscle tissue regeneration", "Skeletal myofibril assembly", "Skeletal system development", "Skeletal system morphogenesis", "Skin development", "Skin epidermis development", "Skin morphogenesis", "Smad protein complex assembly", "Smad protein signal transduction", "Small gtpase mediated signal transduction", "Small molecule biosynthetic process", "Small molecule catabolic process", "Small molecule metabolic process", "Small nucleolar ribonucleoprotein complex assembly", "Small rna loading onto risc", "Smooth muscle adaptation", "Smooth muscle cell apoptotic process", "Smooth muscle cell chemotaxis", "Smooth muscle cell differentiation", "Smooth muscle cell migration", "Smooth muscle cell proliferation", "Smooth muscle contraction", "Smooth muscle tissue development", "Smoothened signaling pathway", "Smoothened signaling pathway involved in dorsal ventral neural tube patterning", "Snare complex assembly", "Sno s rna metabolic process", "Sno s rna processing", "Snorna localization", "Snrna metabolic process", "Snrna modification", "Snrna processing", "Snrna transcription", "Snrna transcription by rna polymerase ii", "Snrna transport", "Sodium ion export across plasma membrane", "Sodium ion homeostasis", "Sodium ion transmembrane transport", "Sodium ion transport", "Somatic diversification of immune receptors", "Somatic diversification of immune receptors via somatic mutation", "Somatic diversification of immunoglobulins", "Somatic diversification of immunoglobulins involved in immune response", "Somatic diversification of t cell receptor genes", "Somatic stem cell population maintenance", "Somite development", "Somite rostral caudal axis specification", "Somitogenesis", "Specification of animal organ identity", "Specification of symmetry", "Sperm capacitation", "Sperm dna condensation", "Sperm egg recognition", "Sperm motility", "Spermatid differentiation", "Spermatid nucleus differentiation", "Spermatogenesis exchange of chromosomal proteins", "Spermidine metabolic process", "Spermine metabolic process", "Sphingoid metabolic process", "Sphingolipid biosynthetic process", "Sphingolipid mediated signaling pathway", "Sphingolipid metabolic process", "Sphingolipid translocation", "Sphingomyelin biosynthetic process", "Sphingomyelin catabolic process", "Sphingomyelin metabolic process", "Sphingosine biosynthetic process", "Spinal cord development", "Spinal cord motor neuron differentiation", "Spindle assembly", "Spindle assembly involved in female meiosis", "Spindle elongation", "Spindle localization", "Spindle midzone assembly", "Spindle organization", "Spleen development", "Spliceosomal complex assembly", "Spliceosomal conformational changes to generate catalytic conformation", "Spliceosomal snrnp assembly", "Spliceosomal tri snrnp complex assembly", "Spontaneous synaptic transmission", "Sprouting angiogenesis", "Srp dependent cotranslational protein targeting to membrane", "Srp dependent cotranslational protein targeting to membrane signal sequence recognition", "Srp dependent cotranslational protein targeting to membrane translocation", "Startle response", "Stem cell differentiation", "Stem cell division", "Stem cell proliferation", "Steroid biosynthetic process", "Steroid catabolic process", "Steroid esterification", "Steroid hormone biosynthetic process", "Steroid hormone mediated signaling pathway", "Steroid hormone secretion", "Steroid metabolic process", "Sterol biosynthetic process", "Sterol homeostasis", "Sterol import", "Sterol metabolic process", "Sterol transport", "Store operated calcium entry", "Stress activated protein kinase signaling cascade", "Stress fiber assembly", "Stress granule assembly", "Stress granule disassembly", "Stress induced premature senescence", "Stress response to metal ion", "Striated muscle adaptation", "Striated muscle cell apoptotic process", "Striated muscle cell development", "Striated muscle cell differentiation", "Striated muscle cell proliferation", "Striated muscle contraction", "Striatum development", "Subpallium development", "Substantia nigra development", "Substrate adhesion dependent cell spreading", "Substrate dependent cell migration", "Substrate dependent cell migration cell extension", "Substrate independent telencephalic tangential migration", "Subtelomeric heterochromatin assembly", "Succinate metabolic process", "Succinate transmembrane transport", "Succinyl coa metabolic process", "Suckling behavior", "Sugar mediated signaling pathway", "Sulfate transport", "Sulfur amino acid biosynthetic process", "Sulfur amino acid catabolic process", "Sulfur amino acid metabolic process", "Sulfur compound biosynthetic process", "Sulfur compound catabolic process", "Sulfur compound metabolic process", "Sulfur compound transport", "Superoxide anion generation", "Superoxide metabolic process", "Suppression of viral release by host", "Supramolecular fiber organization", "Sympathetic ganglion development", "Sympathetic nervous system development", "Synapse assembly", "Synapse maturation", "Synapse organization", "Synapse pruning", "Synaptic assembly at neuromuscular junction", "Synaptic membrane adhesion", "Synaptic signaling", "Synaptic transmission dopaminergic", "Synaptic transmission gabaergic", "Synaptic transmission glutamatergic", "Synaptic vesicle budding", "Synaptic vesicle clustering", "Synaptic vesicle cytoskeletal transport", "Synaptic vesicle docking", "Synaptic vesicle endosomal processing", "Synaptic vesicle exocytosis", "Synaptic vesicle localization", "Synaptic vesicle maturation", "Synaptic vesicle membrane organization", "Synaptic vesicle priming", "Synaptic vesicle recycling", "Synaptic vesicle recycling via endosome", "Synaptic vesicle transport", "Synaptic vesicle uncoating", "Synaptonemal complex organization", "Syncytium formation", "T cell activation", "T cell activation involved in immune response", "T cell apoptotic process", "T cell chemotaxis", "T cell cytokine production", "T cell differentiation", "T cell differentiation in thymus", "T cell differentiation involved in immune response", "T cell extravasation", "T cell homeostasis", "T cell lineage commitment", "T cell mediated cytotoxicity", "T cell mediated immune response to tumor cell", "T cell mediated immunity", "T cell migration", "T cell proliferation", "T cell proliferation involved in immune response", "T cell receptor signaling pathway", "T cell selection", "T cell tolerance induction", "T helper 1 cell differentiation", "T helper 1 type immune response", "T helper 17 cell differentiation", "T helper 17 cell lineage commitment", "T helper 17 type immune response", "T helper 2 cell differentiation", "T helper cell lineage commitment", "T tubule organization", "Tail anchored membrane protein insertion into er membrane", "Tangential migration from the subventricular zone to the olfactory bulb", "Taxis", "Telencephalon development", "Telencephalon glial cell migration", "Telencephalon regionalization", "Telomerase holoenzyme complex assembly", "Telomerase rna localization", "Telomere capping", "Telomere maintenance", "Telomere maintenance in response to dna damage", "Telomere maintenance via recombination", "Telomere maintenance via semi conservative replication", "Telomere maintenance via telomere lengthening", "Telomere organization", "Temperature homeostasis", "Terminal button organization", "Termination of rna polymerase ii transcription", "Terpenoid biosynthetic process", "Terpenoid metabolic process", "Tertiary alcohol metabolic process", "Tetrahydrobiopterin metabolic process", "Tetrahydrofolate biosynthetic process", "Tetrahydrofolate interconversion", "Tetrahydrofolate metabolic process", "Tetrapyrrole biosynthetic process", "Tetrapyrrole catabolic process", "Tetrapyrrole metabolic process", "Thalamus development", "Thiamine containing compound metabolic process", "Thiamine transport", "Thioester biosynthetic process", "Thioester metabolic process", "Thorax and anterior abdomen determination", "Threonine catabolic process", "Threonine metabolic process", "Thrombin activated receptor signaling pathway", "Thymocyte apoptotic process", "Thymus development", "Thyroid gland development", "Thyroid hormone generation", "Thyroid hormone mediated signaling pathway", "Thyroid hormone metabolic process", "Tight junction organization", "Tissue development", "Tissue migration", "Tissue morphogenesis", "Tissue regeneration", "Tissue remodeling", "Tolerance induction", "Toll like receptor 3 signaling pathway", "Toll like receptor 4 signaling pathway", "Toll like receptor 7 signaling pathway", "Toll like receptor 8 signaling pathway", "Toll like receptor 9 signaling pathway", "Toll like receptor signaling pathway", "Tongue development", "Tongue morphogenesis", "Tooth mineralization", "Tor signaling", "Torc1 signaling", "Torc2 signaling", "Toxin metabolic process", "Toxin transport", "Trabecula formation", "Trabecula morphogenesis", "Trachea development", "Trachea formation", "Trachea morphogenesis", "Trail activated apoptotic signaling pathway", "Trans synaptic signaling by lipid", "Trans synaptic signaling by trans synaptic complex", "Transcription by rna polymerase i", "Transcription by rna polymerase iii", "Transcription coupled nucleotide excision repair", "Transcription dependent tethering of rna polymerase ii gene dna at nuclear periphery", "Transcription elongation from rna polymerase i promoter", "Transcription elongation from rna polymerase ii promoter", "Transcription factor catabolic process", "Transcription initiation from rna polymerase i promoter", "Transcription initiation from rna polymerase ii promoter", "Transcription initiation from rna polymerase iii promoter", "Transcription preinitiation complex assembly", "Transcytosis", "Transepithelial chloride transport", "Transepithelial transport", "Transferrin transport", "Transforming growth factor beta activation", "Transforming growth factor beta production", "Transforming growth factor beta receptor signaling pathway", "Transforming growth factor beta1 production", "Transition between fast and slow fiber", "Transition metal ion homeostasis", "Transition metal ion transport", "Translational elongation", "Translational initiation", "Translational readthrough", "Translational termination", "Translesion synthesis", "Translocation of molecules into host", "Transmembrane receptor protein serine threonine kinase signaling pathway", "Transmembrane receptor protein tyrosine kinase signaling pathway", "Transmembrane receptor protein tyrosine phosphatase signaling pathway", "Transmembrane transport", "Transmission of nerve impulse", "Transport along microtubule", "Transport of virus", "Transposition", "Transposition rna mediated", "Tricarboxylic acid cycle", "Tricarboxylic acid metabolic process", "Triglyceride biosynthetic process", "Triglyceride metabolic process", "Tripartite regional subdivision", "Tripeptide transmembrane transport", "Tripeptide transport", "Trivalent inorganic anion homeostasis", "Trna 3 end processing", "Trna 5 end processing", "Trna 5 leader removal", "Trna aminoacylation for mitochondrial protein translation", "Trna catabolic process", "Trna metabolic process", "Trna methylation", "Trna modification", "Trna processing", "Trna pseudouridine synthesis", "Trna thio modification", "Trna threonylcarbamoyladenosine metabolic process", "Trna transcription", "Trna transport", "Trna wobble base modification", "Trna wobble uridine modification", "Trophectodermal cell differentiation", "Trophoblast cell migration", "Trophoblast giant cell differentiation", "Tryptophan transport", "Tube development", "Tube formation", "Tube morphogenesis", "Tubulin complex assembly", "Tubulin deacetylation", "Tumor necrosis factor mediated signaling pathway", "Tumor necrosis factor superfamily cytokine production", "Type 2 immune response", "Type b pancreatic cell apoptotic process", "Type b pancreatic cell development", "Type i interferon production", "Type i pneumocyte differentiation", "Tyrosine catabolic process", "Tyrosine metabolic process", "Tyrosine phosphorylation of stat protein", "U4 snrna 3 end processing", "Ubiquinone metabolic process", "Ubiquitin dependent endocytosis", "Ubiquitin dependent erad pathway", "Ubiquitin dependent glycoprotein erad pathway", "Ubiquitin dependent protein catabolic process via the multivesicular body sorting pathway", "Ubiquitin independent protein catabolic process via the multivesicular body sorting pathway", "Ubiquitin recycling", "Udp glucose metabolic process", "Udp n acetylglucosamine biosynthetic process", "Udp n acetylglucosamine metabolic process", "Ump biosynthetic process", "Unsaturated fatty acid biosynthetic process", "Unsaturated fatty acid metabolic process", "Urate metabolic process", "Urea cycle", "Urea metabolic process", "Ureter development", "Urogenital system development", "Uronic acid metabolic process", "Utp biosynthetic process", "Utp metabolic process", "Uv damage excision repair", "Uv protection", "V d j recombination", "Vacuolar acidification", "Vacuolar localization", "Vacuolar proton transporting v type atpase complex assembly", "Vacuolar transport", "Vacuole organization", "Vagina development", "Valine metabolic process", "Vascular associated smooth muscle cell apoptotic process", "Vascular associated smooth muscle cell differentiation", "Vascular associated smooth muscle cell migration", "Vascular associated smooth muscle cell proliferation", "Vascular associated smooth muscle contraction", "Vascular endothelial cell proliferation", "Vascular endothelial growth factor production", "Vascular endothelial growth factor receptor 2 signaling pathway", "Vascular endothelial growth factor receptor signaling pathway", "Vascular endothelial growth factor signaling pathway", "Vascular process in circulatory system", "Vascular transport", "Vasculature development", "Vasculogenesis", "Vasoconstriction", "Vasodilation", "Ventral spinal cord development", "Ventricular cardiac muscle cell action potential", "Ventricular cardiac muscle cell development", "Ventricular cardiac muscle cell differentiation", "Ventricular cardiac muscle cell membrane repolarization", "Ventricular cardiac muscle tissue development", "Ventricular cardiac muscle tissue morphogenesis", "Ventricular compact myocardium morphogenesis", "Ventricular septum development", "Ventricular septum morphogenesis", "Ventricular system development", "Very long chain fatty acid catabolic process", "Very long chain fatty acid metabolic process", "Very low density lipoprotein particle assembly", "Very low density lipoprotein particle clearance", "Vesicle budding from membrane", "Vesicle cargo loading", "Vesicle cytoskeletal trafficking", "Vesicle docking", "Vesicle docking involved in exocytosis", "Vesicle fusion to plasma membrane", "Vesicle fusion with golgi apparatus", "Vesicle localization", "Vesicle mediated transport", "Vesicle mediated transport between endosomal compartments", "Vesicle mediated transport in synapse", "Vesicle mediated transport to the plasma membrane", "Vesicle organization", "Vesicle targeting", "Vesicle targeting rough er to cis golgi", "Vesicle targeting to from or within golgi", "Vesicle tethering", "Vesicle tethering to golgi", "Vesicle transport along microtubule", "Vesicle uncoating", "Viral budding", "Viral gene expression", "Viral genome replication", "Viral life cycle", "Viral process", "Viral protein processing", "Viral release from host cell", "Viral rna genome replication", "Viral transcription", "Viral translation", "Viral translational termination reinitiation", "Virion assembly", "Virion attachment to host cell", "Visual behavior", "Vitamin a metabolic process", "Vitamin b6 metabolic process", "Vitamin biosynthetic process", "Vitamin catabolic process", "Vitamin d metabolic process", "Vitamin d receptor signaling pathway", "Vitamin k metabolic process", "Vitamin metabolic process", "Vitamin transmembrane transport", "Vitamin transport", "Voluntary musculoskeletal movement", "Walking behavior", "Water homeostasis", "Water soluble vitamin biosynthetic process", "Water soluble vitamin metabolic process", "Water transport", "White fat cell differentiation", "Wnt protein secretion", "Wnt signaling pathway involved in heart development", "Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation", "Wound healing", "Wound healing involved in inflammatory response", "Wound healing spreading of epidermal cells", "Xenobiotic catabolic process", "Xenobiotic export", "Xenobiotic metabolic process", "Xenobiotic transmembrane transport", "Xenobiotic transport", "Xenobiotic transport across blood brain barrier", "Xenophagy", "Xmp metabolic process", "Zinc ion homeostasis", "Zinc ion import across plasma membrane", "Zinc ion transport", "Zygotic determination of anterior posterior axis embryo", "Zymogen activation", "Zymogen inhibition"], "available_proteins": ["AAAS", "AAMP", "AAR2", "AARS", "AARS2", "AASDHPPT", "AASS", "AATF", "ABCB1", "ABCB7", "ABCC1", "ABCD3", "ABCE1", "ABCF1", "ABCF3", "ABHD10", "ABHD12", "ABHD14B", "ABHD6", "ABI1", "ACAA2", "ACACA", "ACACB", "ACAD11", "ACAD9", "ACADM", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACBD5", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT9", "ACOX1", "ACOX3", "ACP1", "ACP2", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN4", "ACTR10", "ACTR1A", "ACTR2", "ACTR3", "ADAR", "ADD1", "ADD3", "ADH5", "ADI1", "ADNP", "ADPGK", "ADPRHL2", "ADRM1", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGK", "AGL", "AGPAT1", "AGPAT5", "AGPS", "AHCY", "AHCYL1", "AHNAK", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AKAP12", "AKAP13", "AKAP8", "AKAP8L", "AKR1A1", "AKR1B1", "AKR7A2", "AKT2", "ALDH18A1", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALG1", "ALG11", "ALG12", "ALKBH5", "ALYREF", "AMOT", "ANAPC1", "ANAPC16", "ANAPC2", "ANAPC5", "ANAPC7", "ANGEL1", "ANKFY1", "ANKHD1", "ANKLE2", "ANKRD17", "ANO10", "ANO6", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA3", "ANXA4", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP1M1", "AP1S2", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "AP3S1", "APEH", "APEX1", "API5", "APLP2", "APOL2", "APOO", "APOOL", "APP", "APRT", "AQR", "ARAF", "ARCN1", "ARF4", "ARF6", "ARFGAP1", "ARFGAP2", "ARFIP1", "ARFIP2", "ARHGAP1", "ARHGAP17", "ARHGDIA", "ARHGEF1", "ARHGEF2", "ARID1A", "ARID3B", "ARIH1", "ARIH2", "ARL1", "ARL2", "ARL3", "ARL6IP1", "ARL6IP5", "ARMC10", "ARMC6", "ARMC8", "ARMCX3", "ARMT1", "ARPC1A", "ARPC2", "ARPC3", "ARPC4", "ARPC5", "ASAH1", "ASCC2", "ASCC3", "ASNA1", "ASNS", "ASPH", "ATAD1", "ATAD2", "ATAD3A", "ATAD3B", "ATE1", "ATG3", "ATG4B", "ATG7", "ATG9A", "ATIC", "ATL2", "ATP13A1", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6", "ATP6AP1", "ATP6AP2", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1D", "ATP6V1E1", "ATP6V1H", "ATP7B", "ATPAF1", "ATPIF1", "ATRIP", "ATXN10", "ATXN2L", "AUP1", "AURKA", "AURKB", "B3GALT6", "B4GAT1", "BABAM1", "BAG2", "BAG4", "BAG5", "BAG6", "BAIAP2", "BAK1", "BANF1", "BANP", "BASP1", "BAZ1A", "BAZ1B", "BCAP31", "BCAS2", "BCCIP", "BCL2L13", "BCLAF1", "BCS1L", "BICD2", "BIRC6", "BLMH", "BLVRA", "BMS1", "BNIP1", "BOD1", "BOLA2*", "BOP1", "BPHL", "BPNT1", "BRAP", "BRAT1", "BRD2", "BRIX1", "BSG", "BTAF1", "BTF3", "BUB1B", "BUB3", "BUD23", "BUD31", "BYSL", "BZW1", "BZW2", "C12orf73", "C17orf75", "C19orf70", "C1QBP", "C21orf59", "C2CD5", "C5orf51", "CAB39", "CACUL1", "CACYBP", "CAD", "CALD1", "CALM3", "CALR", "CAMK1", "CAMK2G", "CAND1", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPRIN1", "CAPZA1", "CAPZA2", "CAPZB", "CARM1", "CARS", "CARS2", "CASK", "CAST", "CBR1", "CBX1", "CBX3", "CBX5", "CBX8", "CCAR1", "CCAR2", "CCDC124", "CCDC134", "CCDC22", "CCDC47", "CCDC6", "CCNB1", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2AP", "CD2BP2", "CD320", "CD47", "CDC123", "CDC16", "CDC20", "CDC23", "CDC27", "CDC34", "CDC37", "CDC40", "CDC42", "CDC5L", "CDC7", "CDC73", "CDCA2", "CDCA8", "CDH2", "CDIPT", "CDK1", "CDK2", "CDK4", "CDK5", "CDK5RAP3", "CDK6", "CDKAL1", "CDKN2A", "CDS2", "CEBPZ", "CECR2", "CELF2", "CENPI", "CENPP", "CENPV", "CEP290", "CEP44", "CEP55", "CERS1", "CERS2", "CETN2", "CFAP20", "CFL1", "CFL2", "CHAC2", "CHAF1A", "CHAF1B", "CHAMP1", "CHCHD3", "CHD1", "CHD1L", "CHD4", "CHERP", "CHID1", "CHKA", "CHMP1A", "CHMP2A", "CHMP2B", "CHMP3", "CHMP4B", "CHMP5", "CHMP7", "CHORDC1", "CHRAC1", "CHST14", "CHTF18", "CIAPIN1", "CIRBP", "CISD1", "CISD2", "CKAP2", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLCC1", "CLCN3", "CLCN7", "CLGN", "CLIC1", "CLIC4", "CLINT1", "CLN5", "CLNS1A", "CLPB", "CLPP", "CLPTM1", "CLPTM1L", "CLPX", "CLTA", "CLTC", "CLU", "CLUH", "CMAS", "CMPK1", "CMTR1", "CNDP2", "CNN3", "CNNM3", "CNNM4", "CNOT1", "CNOT10", "CNOT11", "CNOT2", "CNOT9", "CNP", "CNPY2", "COA3", "COASY", "COG3", "COG4", "COIL", "COLEC12", "COLGALT1", "COMMD1", "COMT", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS7A", "COPS8", "COPZ1", "COQ8A", "COQ9", "CORO1B", "CORO1C", "CORO7", "COTL1", "COX18", "COX2", "COX4I1", "COX5A", "COX5B", "COX6C", "COX7A2", "CPD", "CPNE1", "CPNE3", "CPOX", "CPSF1", "CPSF2", "CPSF3", "CPSF6", "CPSF7", "CPT1A", "CPT2", "CPVL", "CRK", "CRKL", "CRNKL1", "CROT", "CRTAP", "CRYZL1", "CS", "CSDE1", "CSE1L", "CSK", "CSNK1A1", "CSNK2A2", "CSNK2B", "CSRP2", "CSTB", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTCF", "CTDSPL2", "CTNNA1", "CTNNAL1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTPS2", "CTR9", "CTSA", "CTSB", "CTSC", "CTTN", "CTTNBP2NL", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CUTA", "CWC15", "CWC27", "CWF19L1", "CXorf56", "CXorf57", "CYB5B", "CYB5D2", "CYB5R1", "CYB5R3", "CYC1", "CYFIP1", "CYFIP2", "CYP51A1", "DAD1", "DAG1", "DAP3", "DARS", "DARS2", "DAXX", "DAZAP1", "DBN1", "DBNL", "DBT", "DCAF13", "DCAF16", "DCAF7", "DCAKD", "DCD", "DCP1B", "DCPS", "DCTD", "DCTN1", "DCTN2", "DCTN3", "DCTPP1", "DCUN1D1", "DCUN1D5", "DCXR", "DDAH2", "DDB1", "DDI2", "DDOST", "DDRGK1", "DDT", "DDX1", "DDX10", "DDX17", "DDX18", "DDX20", "DDX21", "DDX23", "DDX27", "DDX28", "DDX39A", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX51", "DDX52", "DDX54", "DDX56", "DDX6", "DEGS1", "DEK", "DENR", "DERL1", "DERL2", "DFFA", "DGKE", "DHCR24", "DHCR7", "DHFR", "DHPS", "DHRS4", "DHRS7", "DHRS7B", "DHX15", "DHX16", "DHX29", "DHX30", "DHX36", "DHX37", "DHX38", "DHX8", "DHX9", "DIABLO", "DIAPH1", "DIAPH2", "DIAPH3", "DIDO1", "DIMT1", "DIS3", "DKC1", "DLAT", "DLD", "DLG3", "DLGAP5", "DLST", "DNAAF5", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC13", "DNAJC19", "DNAJC2", "DNAJC3", "DNAJC7", "DNAJC9", "DNM1L", "DNM2", "DNMT1", "DNPH1", "DNTTIP2", "DOCK7", "DOHH", "DOLPP1", "DPAGT1", "DPH2", "DPH5", "DPM1", "DPP3", "DPP9", "DPYSL2", "DPYSL5", "DRG1", "DRG2", "DSC3", "DSG2", "DSP", "DST", "DSTN", "DTYMK", "DUSP12", "DUSP3", "DUSP9", "DUT", "DYM", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNC1LI2", "DYNLL2", "EARS2", "EBNA1BP2", "ECD", "ECE1", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "ECSIT", "EDC3", "EDC4", "EDF1", "EDRF1", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EFL1", "EFTUD2", "EHD1", "EHD4", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B5", "EIF2D", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAC2", "ELAVL1", "ELMO2", "ELMOD2", "ELOA", "ELOB", "ELOC", "ELP1", "ELP2", "ELP3", "EMC1", "EMC2", "EMC4", "EMC7", "EMD", "EMG1", "EML4", "ENAH", "ENDOD1", "ENO1", "ENO2", "ENOPH1", "EPB41", "EPB41L2", "EPB41L3", "EPB41L5", "EPDR1", "EPHA7", "EPHX1", "EPHX2", "EPPK1", "EPRS", "EPS15L1", "ERAL1", "ERAP1", "ERC1", "ERCC2", "ERCC3", "ERCC6L", "ERGIC2", "ERGIC3", "ERH", "ERLIN1", "ERLIN2", "ERMP1", "ERO1A", "ERP29", "ERP44", "ESD", "ESF1", "ESPL1", "ESYT1", "ESYT2", "ETF1", "ETFA", "ETFB", "ETFDH", "ETNK1", "EXO1", "EXOC2", "EXOC3", "EXOC5", "EXOC6", "EXOC6B", "EXOC7", "EXOC8", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC9", "EZR", "F11R", "FABP5", "FADS2", "FAF1", "FAF2", "FAH", "FAM162A", "FAM192A", "FAM208A", "FAM213A", "FAM3C", "FAM49B", "FAM50A", "FAM98A", "FAM98B", "FANCD2", "FANCI", "FAR1", "FARP1", "FARS2", "FARSA", "FARSB", "FASN", "FASTKD2", "FBL", "FBXO21", "FBXO22", "FCGRT", "FDFT1", "FDPS", "FDXR", "FECH", "FEN1", "FERMT2", "FGFR1OP", "FH", "FHL1", "FHOD1", "FIP1L1", "FIS1", "FKBP10", "FKBP14", "FKBP1A", "FKBP2", "FKBP3", "FKBP4", "FKBP5", "FKBP7", "FKBP8", "FKBP9", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FMR1", "FN3KRP", "FNTA", "FNTB", "FOXRED1", "FSCN1", "FTL", "FTO", "FTSJ3", "FUBP1", "FUBP3", "FUCA1", "FUCA2", "FUNDC2", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GADD45GIP1", "GAK", "GAL", "GALK1", "GALNT1", "GALNT2", "GALNT4", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GATAD2B", "GBA", "GBE1", "GBF1", "GCAT", "GCC2", "GCDH", "GCLC", "GCN1", "GDAP1", "GDI1", "GDI2", "GDPD1", "GEMIN4", "GEMIN5", "GET4", "GFM1", "GFPT1", "GGCT", "GGCX", "GGH", "GGPS1", "GHITM", "GIGYF2", "GINS2", "GINS3", "GINS4", "GLA", "GLB1", "GLDC", "GLG1", "GLMN", "GLO1", "GLRX3", "GLS", "GLUD1", "GLYR1", "GM2A", "GMFB", "GMPPB", "GMPS", "GNA13", "GNAI2", "GNAI3", "GNG12", "GNL2", "GNL3", "GNL3L", "GNPAT", "GNPDA1", "GNS", "GOLGA2", "GOLGA3", "GOLGA5", "GOLGB1", "GOLM1", "GOLPH3", "GOLT1B", "GOPC", "GORASP2", "GOSR1", "GOT1", "GOT2", "GPAA1", "GPAM", "GPAT4", "GPATCH4", "GPD2", "GPHN", "GPI", "GPKOW", "GPR107", "GPR89B", "GPS1", "GPT2", "GRAMD1A", "GRB2", "GRHPR", "GRIPAP1", "GRPEL1", "GRSF1", "GRWD1", "GSPT1", "GSR", "GSS", "GSTK1", "GSTM3", "GSTO1", "GTF2B", "GTF2E1", "GTF2F1", "GTF2I", "GTF3C1", "GTF3C2", "GTF3C3", "GTPBP1", "GTPBP10", "GTPBP3", "GTPBP4", "GUF1", "GYG1", "GYS1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACD2", "HACD3", "HACL1", "HADH", "HADHA", "HADHB", "HAT1", "HAUS1", "HAUS3", "HAUS4", "HAUS5", "HBS1L", "HCCS", "HCFC1", "HDAC1", "HDAC2", "HDGF", "HDGFL2", "HDHD2", "HDHD5", "HDLBP", "HEATR1", "HEATR3", "HEBP1", "HEBP2", "HECTD1", "HELLS", "HEXA", "HEXB", "HGS", "HIBADH", "HIBCH", "HIKESHI", "HINT2", "HIRIP3", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLTF", "HM13", "HMBS", "HMCES", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMGCL", "HMGCR", "HMGCS1", "HMGN2", "HMOX1", "HMOX2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPLL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HP1BP3", "HPRT1", "HPS6", "HS2ST1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA13", "HSPA14", "HSPA1B", "HSPA2", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPB1", "HSPBP1", "HSPD1", "HSPE1", "HSPH1", "HTATSF1", "HTRA2", "HUS1", "HUWE1", "HYOU1", "IARS", "IARS2", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDI1", "IFT27", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IK", "IKBIP", "IKBKG", "ILF2", "ILF3", "ILK", "ILKAP", "ILVBL", "IMMT", "IMP3", "IMP4", "IMPA1", "IMPAD1", "IMPDH1", "IMPDH2", "INA", "INCENP", "INTS11", "INTS14", "INTS3", "INTS7", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IQGAP2", "IRS4", "IST1", "ITCH", "ITGB1", "ITM2C", "ITPA", "IVD", "JAGN1", "JUP", "KARS", "KAT7", "KCTD12", "KCTD5", "KDELC2", "KDELR1", "KDM1A", "KDM1B", "KDM2A", "KDM3B", "KDSR", "KHDRBS1", "KHSRP", "KIAA0368", "KIAA0391", "KIAA1468", "KIF11", "KIF14", "KIF15", "KIF18B", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF4A", "KIF5B", "KIFBP", "KIFC1", "KIN", "KLC1", "KLC2", "KMT2A", "KNTC1", "KPNA1", "KPNA2", "KPNA3", "KPNA6", "KPNB1", "KRI1", "KRR1", "KTN1", "L2HGDH", "LAMP1", "LAMP2", "LAMTOR1", "LANCL2", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LAS1L", "LASP1", "LBR", "LDAH", "LDHA", "LDHB", "LEMD2", "LEMD3", "LETM1", "LGALS3BP", "LGMN", "LIG1", "LIG3", "LIMA1", "LIPA", "LMAN2", "LMF2", "LMNA", "LMNB1", "LNPEP", "LNPK", "LONP1", "LPCAT1", "LPCAT3", "LPGAT1", "LRBA", "LRP1", "LRPAP1", "LRPPRC", "LRRC40", "LRRC47", "LRRC59", "LRWD1", "LSM2", "LSM3", "LSM4", "LSM6", "LSM7", "LSS", "LTA4H", "LTV1", "LUC7L", "LUC7L2", "LYAR", "LYPLA1", "LYSMD3", "LZTFL1", "M6PR", "MACF1", "MAD2L1", "MAGED2", "MAGT1", "MAIP1", "MAK16", "MAN1A1", "MAN2A1", "MAN2B1", "MANF", "MAP1B", "MAP1S", "MAP2K2", "MAP4", "MAPK1", "MAPK14", "MAPRE1", "MAPRE2", "MARC1", "MARCH5", "MARS", "MASTL", "MAT2A", "MAT2B", "MATR3", "MAU2", "MAVS", "MBD3", "MBOAT7", "MCAT", "MCCC1", "MCCC2", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCMBP", "MCTS1", "MCU", "MCUR1", "MDC1", "MDH1", "MDH2", "MDN1", "ME1", "ME2", "MECP2", "MED21", "MED23", "MED24", "MED25", "MEPCE", "METAP2", "METTL13", "METTL14", "METTL3", "METTL7A", "METTL7B", "METTL9", "MFN1", "MFN2", "MFSD3", "MFSD5", "MGEA5", "MGME1", "MGST2", "MGST3", "MIA2", "MIA3", "MICU1", "MICU2", "MIF", "MINDY3", "MIPEP", "MKI67", "MKRN2", "MLEC", "MMAB", "MMS19", "MOGS", "MORF4L1", "MOSPD2", "MOV10", "MPC2", "MPDU1", "MPG", "MPHOSPH10", "MPI", "MPP1", "MPP6", "MPRIP", "MPST", "MPV17", "MPV17L2", "MRC2", "MRE11", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL14", "MRPL15", "MRPL19", "MRPL22", "MRPL23", "MRPL24", "MRPL28", "MRPL3", "MRPL37", "MRPL44", "MRPL55", "MRPL58", "MRPL9", "MRPS11", "MRPS15", "MRPS16", "MRPS18A", "MRPS27", "MRPS30", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRRF", "MRTO4", "MSH2", "MSH3", "MSH6", "MSI2", "MSMO1", "MSN", "MSTO1", "MTA1", "MTA2", "MTAP", "MTBP", "MTCH1", "MTCH2", "MTDH", "MTFP1", "MTHFD1", "MTHFD1L", "MTHFD2", "MTMR14", "MTMR2", "MTOR", "MTPAP", "MTPN", "MTR", "MTX1", "MTX2", "MUT", "MVK", "MYBBP1A", "MYCBP", "MYDGF", "MYEF2", "MYG1", "MYH10", "MYH9", "MYL6", "MYO1B", "MYO1C", "MYO1D", "MYO6", "NAA15", "NAA25", "NAA35", "NAA40", "NAA50", "NADK2", "NAE1", "NAF1", "NAGA", "NAGLU", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NAPG", "NARS", "NASP", "NAT10", "NAXE", "NCAPD2", "NCAPD3", "NCAPG", "NCAPG2", "NCAPH", "NCBP1", "NCBP3", "NCDN", "NCKAP1", "NCL", "NCLN", "NCSTN", "ND1", "NDC1", "NDUFA11", "NDUFA13", "NDUFA4", "NDUFA5", "NDUFA7", "NDUFA8", "NDUFA9", "NDUFAF2", "NDUFAF3", "NDUFAF4", "NDUFAF7", "NDUFB1", "NDUFB10", "NDUFB3", "NDUFB4", "NDUFB5", "NDUFB6", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS6", "NDUFS7", "NDUFS8", "NDUFV1", "NDUFV2", "NECAP2", "NEFL", "NEFM", "NEK9", "NELFCD", "NELFE", "NEMF", "NENF", "NES", "NFATC2IP", "NFU1", "NGDN", "NHP2", "NIFK", "NIP7", "NIPSNAP1", "NIPSNAP2", "NKRF", "NKTR", "NLE1", "NLN", "NLRX1", "NME1", "NMT1", "NNT", "NOA1", "NOB1", "NOC2L", "NOC3L", "NOC4L", "NOL10", "NOL11", "NOL6", "NOL8", "NOL9", "NOLC1", "NOM1", "NONO", "NOP14", "NOP16", "NOP2", "NOP53", "NOP56", "NOP58", "NOP9", "NOSIP", "NPC1", "NPC2", "NPEPPS", "NPLOC4", "NPM1", "NRDC", "NSA2", "NSD2", "NSDHL", "NSF", "NSMCE2", "NSUN2", "NSUN5", "NT5C2", "NT5C3B", "NT5DC1", "NT5DC2", "NTHL1", "NTMT1", "NUB1", "NUBP2", "NUBPL", "NUCB1", "NUCB2", "NUCKS1", "NUDC", "NUDCD2", "NUDT1", "NUDT16L1", "NUDT21", "NUDT5", "NUDT9", "NUF2", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP160", "NUP188", "NUP205", "NUP210", "NUP214", "NUP35", "NUP37", "NUP43", "NUP50", "NUP54", "NUP58", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NUTF2", "NVL", "NXF1", "NXN", "OAT", "OCIAD1", "OCLN", "OCRL", "OGDH", "OGT", "OLA1", "OPA1", "OPA3", "OSBP", "OSBPL3", "OSBPL6", "OSBPL8", "OSBPL9", "OSGEP", "OTUB1", "OTUD4", "OTUD7B", "OXA1L", "OXCT1", "OXSR1", "P3H1", "P3H4", "P4HA1", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PAF1", "PAFAH1B1", "PAFAH1B2", "PAFAH1B3", "PAICS", "PAIP1", "PAIP2", "PAK1IP1", "PAK2", "PALLD", "PANK4", "PAPOLA", "PARG", "PARK7", "PARN", "PARP1", "PATL1", "PAWR", "PBK", "PBRM1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCID2", "PCK2", "PCLAF", "PCM1", "PCMT1", "PCNA", "PCNP", "PCYOX1", "PDCD11", "PDCD5", "PDCD6", "PDCD6IP", "PDCL3", "PDE12", "PDE6D", "PDHA1", "PDHB", "PDIA3", "PDIA4", "PDIA5", "PDIA6", "PDK3", "PDLIM1", "PDLIM5", "PDLIM7", "PDS5A", "PDS5B", "PDXDC1", "PDXK", "PEBP1", "PECR", "PEF1", "PELO", "PELP1", "PEPD", "PES1", "PEX11A", "PEX14", "PEX16", "PEX19", "PEX5", "PFAS", "PFDN2", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGM3", "PGP", "PGRMC1", "PGRMC2", "PHAX", "PHB", "PHB2", "PHC2", "PHF5A", "PHF6", "PHGDH", "PHIP", "PHKA1", "PI4K2A", "PI4KB", "PIBF1", "PICALM", "PIGK", "PIGS", "PIGT", "PIGU", "PIK3R4", "PIN4", "PINX1", "PIP4K2C", "PIR", "PISD", "PITHD1", "PITPNB", "PITRM1", "PKM", "PKMYT1", "PKN1", "PKN2", "PLA2G15", "PLAA", "PLBD2", "PLCG1", "PLD3", "PLD6", "PLEC", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLRG1", "PLS3", "PM20D2", "PMF1", "PMPCA", "PMPCB", "PMVK", "PNKP", "PNN", "PNP", "PNPLA6", "PNPT1", "PODXL", "POFUT1", "POGZ", "POLA1", "POLA2", "POLD1", "POLD2", "POLD3", "POLDIP2", "POLDIP3", "POLE", "POLE3", "POLE4", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2A", "POLR2D", "POLR2G", "POLR2L", "POLR3A", "POLR3C", "POLRMT", "PON2", "POP1", "POR", "PPA2", "PPAN", "PPAT", "PPIB", "PPIC", "PPID", "PPIF", "PPIH", "PPIL1", "PPIL3", "PPIL4", "PPM1G", "PPME1", "PPOX", "PPP1CA", "PPP1CB", "PPP1R10", "PPP1R12A", "PPP1R8", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP2R5E", "PPP3CA", "PPP4C", "PPP4R1", "PPP4R3A", "PPP5C", "PPP6C", "PPP6R3", "PPT1", "PPT2", "PPWD1", "PRAF2", "PRC1", "PRCC", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PREP", "PREPL", "PRIM1", "PRIM2", "PRKAA2", "PRKACA", "PRKAG1", "PRKAR1A", "PRKAR2A", "PRKCB", "PRKCSH", "PRKDC", "PRKRA", "PRMT1", "PRMT3", "PRMT5", "PRMT9", "PRPF19", "PRPF31", "PRPF38B", "PRPF39", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPSAP1", "PRPSAP2", "PRRC1", "PRRC2C", "PRTFDC1", "PSAP", "PSAT1", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD6", "PSMD7", "PSMD8", "PSMD9", "PSME1", "PSME2", "PSME3", "PSME4", "PSMG1", "PSPC1", "PTBP1", "PTCD3", "PTDSS1", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK7", "PTPA", "PTPMT1", "PTPN1", "PTPN11", "PTPRF", "PTRH2", "PUDP", "PUF60", "PUM1", "PUM3", "PURA", "PUS7", "PWP1", "PWP2", "PXMP2", "PXN", "PYCR1", "PYCR2", "PYCR3", "PYGB", "PYGL", "QARS", "QKI", "QRSL1", "QSOX2", "QTRT2", "RAB10", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB1B", "RAB21", "RAB24", "RAB31", "RAB39A", "RAB3GAP1", "RAB3GAP2", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RAB8A", "RAB9A", "RABEP1", "RABEPK", "RABGAP1", "RAC1", "RACGAP1", "RACK1", "RAD21", "RAD23A", "RAD23B", "RAD50", "RAE1", "RAI14", "RALA", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP6", "RANBP9", "RANGAP1", "RAP2B", "RAPGEF2", "RARS", "RARS2", "RAVER1", "RBBP5", "RBBP6", "RBBP7", "RBM10", "RBM12", "RBM14", "RBM17", "RBM19", "RBM22", "RBM25", "RBM26", "RBM27", "RBM28", "RBM39", "RBM4", "RBM5", "RBM6", "RBM8A", "RBMX", "RBP1", "RCC1", "RCC2", "RCL1", "RCN1", "RDH11", "RDH13", "RDH14", "RDX", "RECQL", "REEP4", "REEP5", "RER1", "RETREG3", "RETSAT", "REXO4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RFT1", "RHBDD2", "RHEB", "RHOG", "RHOT1", "RHOT2", "RIDA", "RIF1", "RINT1", "RMC1", "RMDN1", "RMDN3", "RMND1", "RNASEH2A", "RNASET2", "RNF139", "RNF14", "RNF20", "RNF219", "RNF40", "RNH1", "RNPEP", "ROCK1", "RPA1", "RPA2", "RPF1", "RPF2", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPN1", "RPN2", "RPP30", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS28", "RPS29", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RPTOR", "RPUSD3", "RRBP1", "RRM1", "RRM2", "RRP1", "RRP12", "RRP15", "RRP1B", "RRP36", "RRP8", "RRP9", "RRS1", "RSL1D1", "RSL24D1", "RSPRY1", "RSU1", "RTCB", "RTN2", "RTN3", "RTN4", "RTN4IP1", "RTRAF", "RUFY1", "RUVBL1", "RUVBL2", "S100A11", "S100A13", "SAAL1", "SACM1L", "SAE1", "SAFB", "SAFB2", "SAMD4B", "SAMHD1", "SAMM50", "SAP18", "SAR1A", "SARM1", "SARNP", "SARS", "SARS2", "SART1", "SART3", "SBDS", "SCAF1", "SCAF4", "SCAMP1", "SCAMP2", "SCAMP3", "SCARB1", "SCARB2", "SCCPDH", "SCD", "SCFD1", "SCML2", "SCO1", "SCO2", "SCP2", "SCPEP1", "SCRIB", "SCRN1", "SDAD1", "SDCBP", "SDF4", "SDHA", "SDHB", "SEC11A", "SEC16A", "SEC22B", "SEC23A", "SEC23B", "SEC23IP", "SEC24A", "SEC24B", "SEC24C", "SEC24D", "SEC31A", "SEC61A1", "SEC61B", "SEC61G", "SEC62", "SEC63", "SEH1L", "SEL1L", "SENP3", "SEPHS1", "SEPT11", "SEPT2", "SEPT6", "SEPT7", "SEPT9", "SERBP1", "SERPINB6", "SERPINH1", "SET", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFXN1", "SFXN2", "SFXN4", "SGPL1", "SGTA", "SH3GL1", "SH3GLB1", "SH3GLB2", "SHMT1", "SHMT2", "SIGMAR1", "SIN3A", "SIRT1", "SKIV2L", "SKIV2L2", "SKP1", "SKP2", "SLC12A9", "SLC16A1", "SLC19A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A17", "SLC25A19", "SLC25A20", "SLC25A21", "SLC25A22", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A33", "SLC25A4", "SLC25A40", "SLC25A42", "SLC25A5", "SLC25A6", "SLC27A4", "SLC30A5", "SLC30A6", "SLC33A1", "SLC35A4", "SLC35B2", "SLC35F2", "SLC39A14", "SLC3A2", "SLC4A7", "SLC6A15", "SLC9A3R1", "SLFN11", "SLIRP", "SLIT2", "SLK", "SLTM", "SMAP1", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC6", "SMG5", "SMN1*", "SMNDC1", "SMPD4", "SMS", "SMU1", "SMYD3", "SNAP23", "SND1", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPC", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNW1", "SNX1", "SNX12", "SNX17", "SNX19", "SNX2", "SNX27", "SNX3", "SNX4", "SNX5", "SNX6", "SNX9", "SOAT1", "SOD2", "SON", "SORD", "SPAG9", "SPART", "SPATA5", "SPC24", "SPC25", "SPCS2", "SPECC1L", "SPEN", "SPHK2", "SPNS1", "SPR", "SPTAN1", "SPTBN1", "SPTBN2", "SPTLC1", "SPTLC2", "SQLE", "SQSTM1", "SRCAP", "SREK1", "SRI", "SRM", "SRP14", "SRP54", "SRP68", "SRP72", "SRP9", "SRPK1", "SRPK2", "SRPRA", "SRPRB", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF3", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSNA1", "SSR1", "SSRP1", "STAG1", "STAG2", "STAM", "STAMBP", "STARD3", "STARD3NL", "STAT1", "STAT3", "STAU1", "STAU2", "STIM1", "STIP1", "STK26", "STK4", "STMN1", "STOM", "STOML2", "STRAP", "STRBP", "STRN", "STT3A", "STT3B", "STX10", "STX12", "STX18", "STX3", "STX4", "STX5", "STX7", "STX8", "STXBP3", "STXBP4", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGP2", "SUGT1", "SUN1", "SUN2", "SUPT16H", "SUPT5H", "SUPT6H", "SUPV3L1", "SURF4", "SURF6", "SUZ12", "SV2A", "SYAP1", "SYMPK", "SYNCRIP", "SYNE2", "SYNGR2", "SYNJ2BP", "SYS1", "TAB1", "TACC3", "TADA3", "TAF15", "TAF6L", "TAGLN2", "TALDO1", "TAOK1", "TAP1", "TARDBP", "TARS", "TARS2", "TBC1D13", "TBC1D15", "TBC1D2B", "TBC1D4", "TBC1D9B", "TBCA", "TBCD", "TBCE", "TBL2", "TBL3", "TBRG4", "TCAF1", "TCEA1", "TCERG1", "TCOF1", "TCP1", "TDRKH", "TECR", "TELO2", "TERF2IP", "TES", "TEX264", "TFAM", "TFB1M", "TFCP2", "TFG", "TFIP11", "TFRC", "THOC1", "THOC2", "THOC3", "THOC5", "THOC6", "THOP1", "THRAP3", "THUMPD1", "THUMPD3", "TIA1", "TIAL1", "TIGAR", "TIMELESS", "TIMM10", "TIMM10B", "TIMM13", "TIMM17A", "TIMM17B", "TIMM23", "TIMM44", "TIMM50", "TIMM8B", "TIMM9", "TIPRL", "TJP1", "TK1", "TKT", "TLCD1", "TLN1", "TM9SF2", "TM9SF3", "TM9SF4", "TMCO1", "TMED10", "TMED2", "TMED4", "TMED5", "TMED7", "TMED9", "TMEM109", "TMEM126A", "TMEM126B", "TMEM14C", "TMEM165", "TMEM167A", "TMEM199", "TMEM201", "TMEM214", "TMEM230", "TMEM259", "TMEM30A", "TMEM33", "TMEM38B", "TMEM43", "TMEM59", "TMEM65", "TMEM87A", "TMEM97", "TMF1", "TMOD1", "TMOD3", "TMTC3", "TMX1", "TMX2", "TMX3", "TNKS1BP1", "TNPO1", "TNPO2", "TNPO3", "TOE1", "TOMM20", "TOMM22", "TOMM34", "TOMM40", "TOMM5", "TOMM70", "TOP1", "TOP2A", "TOP2B", "TOR1AIP1", "TOR1B", "TP53", "TP53I11", "TPD52", "TPD52L2", "TPI1", "TPM1", "TPM3", "TPM4", "TPP1", "TPP2", "TPR", "TPT1", "TPX2", "TRA2A", "TRA2B", "TRAF2", "TRAM1", "TRAP1", "TRAPPC5", "TRIM21", "TRIM25", "TRIM28", "TRIM33", "TRIP12", "TRIP13", "TRIR", "TRMT10C", "TRMT11", "TRMT1L", "TRMT2A", "TRMU", "TROVE2", "TRRAP", "TRUB1", "TSFM", "TSG101", "TSN", "TSNAX", "TSPAN10", "TSPAN6", "TSPO", "TSR1", "TST", "TTC1", "TTC19", "TTC26", "TTC37", "TTC4", "TTK", "TTLL12", "TTYH3", "TUBB", "TUBB2A", "TUBB2B", "TUBB3", "TUBB4B", "TUBB6", "TUBGCP2", "TUBGCP3", "TUBGCP4", "TUFM", "TWF1", "TWF2", "TWISTNB", "TWNK", "TXLNA", "TXLNG", "TXNDC12", "TXNDC17", "TXNDC5", "TXNDC9", "TXNRD1", "TYMS", "U2AF1", "U2AF2", "U2SURP", "UAP1", "UBA1", "UBA2", "UBA3", "UBA6", "UBAC1", "UBAP2L", "UBE2J1", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2O", "UBE2S", "UBE3A", "UBE4A", "UBE4B", "UBLCP1", "UBP1", "UBQLN2", "UBQLN4", "UBR4", "UBR5", "UBTF", "UBXN1", "UBXN4", "UBXN7", "UCHL5", "UCK2", "UFC1", "UFD1", "UFL1", "UFM1", "UGCG", "UGGT1", "UGP2", "UGT8", "UHRF1", "ULK3", "UMPS", "UNC119", "UNC119B", "UNC45A", "UNG", "UPF1", "UQCC2", "UQCR10", "UQCRB", "UQCRC1", "UQCRC2", "UQCRQ", "URB1", "UROD", "USO1", "USP10", "USP11", "USP14", "USP28", "USP36", "USP39", "USP47", "USP48", "USP5", "USP7", "USP9X", "UTP11", "UTP14A", "UTP15", "UTP18", "UTP20", "UTP3", "UTP4", "UTP6", "UTRN", "UXT", "VAMP7", "VANGL1", "VAPA", "VAPB", "VARS1", "VAT1", "VBP1", "VCL", "VCP", "VDAC1", "VDAC2", "VDAC3", "VIM", "VIRMA", "VKORC1L1", "VMP1", "VPS13A", "VPS13D", "VPS16", "VPS18", "VPS26A", "VPS29", "VPS33A", "VPS33B", "VPS35", "VPS37B", "VPS4A", "VPS4B", "VPS51", "VPS52", "VPS53", "VRK1", "VRK3", "WAPL", "WARS", "WASHC5", "WBP11", "WBP2", "WDHD1", "WDR1", "WDR11", "WDR12", "WDR18", "WDR26", "WDR3", "WDR34", "WDR36", "WDR41", "WDR43", "WDR46", "WDR48", "WDR5", "WDR6", "WDR61", "WDR70", "WDR75", "WDR77", "WDR82", "WFS1", "WIPI2", "WIZ", "WLS", "XAB2", "XPNPEP1", "XPNPEP3", "XPO1", "XPO4", "XPO5", "XPO7", "XPOT", "XRCC1", "XRCC5", "XRCC6", "XRN2", "YARS", "YARS2", "YBX1", "YBX3", "YIF1A", "YIPF4", "YIPF5", "YKT6", "YLPM1", "YME1L1", "YRDC", "YTHDC1", "YTHDC2", "YTHDF3", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2", "ZC3H11A", "ZC3H14", "ZC3H15", "ZC3H18", "ZC3HAV1", "ZC3HC1", "ZCCHC3", "ZCRB1", "ZDHHC13", "ZFYVE16", "ZMPSTE24", "ZNF207", "ZNF281", "ZNF318", "ZNF326", "ZNF512B", "ZNF622", "ZNF638", "ZPR1", "ZRANB2", "ZW10", "ZWINT", "ZYX"], "leading_proteins": ["AARS2", "AASDHPPT", "ABCB1", "ABCB7", "ABCC1", "ABCD3", "ABHD10", "ABHD12", "ACAT2", "ACBD5", "ACOX1", "ACOX3", "ACP2", "ACSL3", "ACTN4", "ACTR3", "ADPGK", "AGK", "AGPAT5", "AGPS", "AIFM1", "AKAP12", "AKT2", "ALDH18A1", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALG1", "ALG11", "ALG12", "ANAPC2", "ANAPC5", "ANAPC7", "ANKLE2", "ANO10", "ANO6", "ANXA1", "ANXA3", "APLP2", "APOL2", "APOO", "APOOL", "APP", "ARF4", "ARFGAP1", "ARFIP2", "ARL1", "ARL6IP1", "ARL6IP5", "ARMCX3", "ASAH1", "ASNA1", "ATAD1", "ATAD3A", "ATAD3B", "ATIC", "ATL2", "ATP13A1", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP5B", "ATP5F1", "ATP5I", "ATP5L", "ATP6", "ATP6AP1", "ATP6AP2", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP7B", "AURKA", "AURKB", "B3GALT6", "B4GAT1", "BAG4", "BAG6", "BAIAP2", "BAK1", "BCAP31", "BCL2L13", "BNIP1", "BRAT1", "BSG", "BUB1B", "C12orf73", "C19orf70", "C1QBP", "CALM3", "CAMK1", "CANX", "CCDC47", "CD320", "CD47", "CDC16", "CDC20", "CDC34", "CDC37", "CDC40", "CDC42", "CDC7", "CDIPT", "CDK1", "CDK4", "CDS2", "CENPI", "CERS1", "CERS2", "CETN2", "CHCHD3", "CHID1", "CHMP2A", "CHMP3", "CHORDC1", "CHST14", "CIRBP", "CISD1", "CLCC1", "CLCN3", "CLCN7", "CLN5", "CLPP", "CLPTM1", "CLU", "CLUH", "CNNM3", "CNNM4", "CNOT2", "COA3", "COMMD1", "COMT", "COPS3", "COPS4", "COPS5", "COQ9", "COX18", "COX2", "COX4I1", "COX5A", "COX7A2", "CPT1A", "CPT2", "CRTAP", "CSNK2A2", "CTDSPL2", "CTR9", "CTSA", "CTSB", "CTTNBP2NL", "CYB5B", "CYC1", "CYFIP1", "CYP51A1", "DAG1", "DARS2", "DCAKD", "DCTN2", "DCTPP1", "DDB1", "DDRGK1", "DDX3X", "DEGS1", "DERL1", "DERL2", "DGKE", "DHCR24", "DHCR7", "DHFR", "DHRS4", "DHRS7", "DHRS7B", "DHX36", "DIABLO", "DLD", "DNAJC1", "DNAJC19", "DNM1L", "DNM2", "DOCK7", "DOHH", "DOLPP1", "DPAGT1", "DSG2", "EARS2", "ECE1", "EHD4", "ELMOD2", "EMC2", "EMC4", "EMC7", "EMD", "ENOPH1", "EPDR1", "EPHA7", "EPHX1", "ERAP1", "ERC1", "ERCC2", "ERGIC2", "ERGIC3", "ERLIN1", "ESYT1", "ESYT2", "EXO1", "EXOSC10", "EXOSC3", "FADS2", "FAM162A", "FAM49B", "FANCD2", "FASN", "FDFT1", "FECH", "FGFR1OP", "FIS1", "FKBP10", "FKBP14", "FKBP1A", "FKBP7", "FKBP8", "FKBP9", "FLOT1", "FLOT2", "FMR1", "FNTA", "FOXRED1", "FUCA1", "FUCA2", "FUNDC2", "FUS", "FXR1", "G6PD", "GAA", "GAL", "GALNT1", "GALNT4", "GBA", "GCDH", "GFM1", "GGCX", "GHITM", "GINS2", "GLA", "GLB1", "GLDC", "GLS", "GLUD1", "GM2A", "GNAI2", "GNL3L", "GNPAT", "GOLGA5", "GOLGB1", "GOLPH3", "GOPC", "GOSR1", "GPAA1", "GPAM", "GPAT4", "GPATCH4", "GPD2", "GPR107", "GPR89B", "GSTO1", "GTF2B", "HACD2", "HACD3", "HADH", "HADHA", "HCCS", "HDAC1", "HELLS", "HEXA", "HGS", "HIKESHI", "HK2", "HLA-A", "HLA-B", "HLA-C", "HMOX1", "HMOX2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPK", "HNRNPU", "HPS6", "HS2ST1", "HSD17B11", "HSD17B12", "HSD17B4", "HSPA9", "HSPB1", "HTRA2", "ICMT", "IGF2R", "IKBIP", "ILK", "ILVBL", "IMMT", "IMPAD1", "INA", "IPO5", "IPO7", "IPO9", "IST1", "ITCH", "ITGB1", "ITM2C", "JAGN1", "KDELR1", "KDM1B", "KDSR", "KHDRBS1", "KHSRP", "KIF14", "KMT2A", "KNTC1", "KPNA2", "KPNA3", "LAMP1", "LAMP2", "LBR", "LDAH", "LETM1", "LGALS3BP", "LGMN", "LMAN2", "LMF2", "LMNA", "LNPEP", "LONP1", "LPCAT1", "LPCAT3", "LPGAT1", "LYSMD3", "MAGT1", "MAIP1", "MAN2A1", "MAPK14", "MAPRE1", "MAPRE2", "MARCH5", "MASTL", "MAVS", "MBOAT7", "MCL1", "MCM7", "MCU", "MCUR1", "MED25", "MFN1", "MFN2", "MFSD3", "MGST2", "MGST3", "MIA2", "MICU1", "MICU2", "MIF", "MIPEP", "MKRN2", "MOSPD2", "MOV10", "MPC2", "MPDU1", "MPP1", "MPST", "MPV17L2", "MRPS18A", "MSMO1", "MTAP", "MTCH1", "MTCH2", "MTDH", "MTFP1", "MTOR", "MTX1", "MYL6", "NAA40", "NAGA", "NAGLU", "NAMPT", "NASP", "NAT10", "NCSTN", "ND1", "NDC1", "NDUFA11", "NDUFA13", "NDUFA4", "NDUFA8", "NDUFAF2", "NDUFB1", 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79.49271844660194 0.9914207279546418 0.2992612012372248 13.467745416506318 12.62980929789956 2.1277799030157807 0.3627370007757806 0.0015872344717617 0.6637318598957465 0.9409248436034204 0.1443752551553142 0.0026195516628787 +Intrinsic component of mitochondrial inner membrane 24 33 4.403021311389612 1.0675367477563924e-05 13.946601941747574 31.446601941747577 1.7062420859184484 0.2149692261988765 6.992163651608136 3.3601842163433866 1.8185871159494191 0.3070405082296492 2.2096337184834587e-13 0.0017444833819259 7.190935412424749e-06 1.3300594286088582e-09 3.744613778310581e-13 +Outer membrane 39 90 3.98588531858676 6.722897942856854e-05 28.936893203883496 87.79611650485437 1.4859238244628277 0.3236686433663402 11.632349354832256 8.24751710010496 1.9336855473946637 0.38878066573106 1.4297957334880106e-12 0.0002137267005037 5.356911195143742e-05 1.6665592006603743e-09 1.2078631445569312e-13 +Lysosomal lumen 21 36 3.957621761587872 7.56997016688743e-05 18.075242718446603 34.54368932038835 0.7848519845050315 0.1014568164283454 6.206531846566726 3.2976210873168883 3.038689298289951 0.2012423645269794 1.312885393854744e-13 0.0041986670986062 0.0004560267254993 5.415355889493603e-09 2.389160084472316e-13 +Endoplasmic reticulum protein containing complex 26 62 3.776348429077811 0.0001591443286794 20.067961165048544 61.213592233009706 0.544324442160867 0.4875881372361492 7.672624563199495 5.300944201362535 1.5348103009085623 0.3893079894443684 4.902342565837374e-10 0.4072806445693771 0.6457888771265868 0.000237722407871 8.720963818017027e-10 +Secretory granule membrane 31 71 3.716045694183863 0.0002023650006046 19.699029126213592 69.8495145631068 0.9295860214656708 0.3887665887416008 7.284889203542463 7.49087955205396 1.5950364553562375 0.3903287060113383 2.1070031910595754e-07 0.2159364989363957 0.2475305235196633 0.000101536775909 3.733686871985506e-07 +Organelle inner membrane 118 238 3.709010691994703 0.0002080706425235 79.6747572815534 237.5995145631068 1.5941979045672914 0.3906136455525962 32.81710191865129 21.467005610038825 2.570753705211445 0.4244355950981394 4.3932272163628116e-33 1.3055715209293076e-08 1.837707129439625e-11 9.20718324547963e-21 7.736648957787534e-33 +Respirasome 17 41 3.6090078926734575 0.0003073702591238 15.08495145631068 43.37378640776699 1.2524823540042158 0.2922262294299136 6.290312072426717 4.489587979561489 1.7783434517583476 0.3462844006183536 4.244151322957377e-08 0.0078165677457274 0.0012638007556123 6.908838981678768e-07 6.646554352148302e-08 +Endoplasmic reticulum golgi intermediate compartment membrane 19 24 3.5780284419697126 0.0003461957864452 10.49271844660194 25.839805825242717 1.5441023898993702 0.2324243418613106 5.505729177420246 3.7718384126099376 1.49831312620529 0.2965572765953523 5.616432053889825e-06 0.0022960708364777 0.0153233347656195 0.0095773823981548 7.587265040307096e-06 +Azurophil granule membrane 13 22 3.345071175309181 0.0008226145729959 7.856796116504855 21.259708737864077 1.0757479237162697 0.2373572682944545 3.393508570011604 2.63895903142419 1.639408148995933 0.2881313440808664 7.26820842936339e-07 0.1991580424676108 0.356411341728891 0.0007104965070469 9.933951292388155e-07 +Transporter complex 28 58 3.3431232649897167 0.0008284109298655 16.033980582524272 55.199029126213595 0.256193630237002 0.358562058071074 7.704418772430675 7.665912382074106 1.666161547187811 0.3440522205931707 6.057623936912014e-08 0.0339714602069511 0.0028249686746922 0.0027415319252224 1.0534910250074017e-07 +Golgi membrane 66 130 3.299481438129292 0.000968636331295 41.28398058252427 131.19174757281553 1.6327747521284677 0.3511039607499193 15.277988344159814 17.44963987873233 1.926180921267262 0.4033858283713009 4.543464780942909e-08 0.0522091470058362 0.0022838036610655 8.694374961064729e-06 4.09044930811326e-08 +Vacuolar lumen 24 67 3.25430536751614 0.0011367002100333 22.262135922330096 63.33980582524272 0.6562244405592584 0.1887666227175413 6.920437110961116 4.902057024259538 2.8947011026985514 0.298290072492813 1.815286141949765e-09 0.0176779282664691 0.0047300594781523 3.1359916965687687e-06 3.198587975176038e-09 +Outer mitochondrial membrane protein complex 12 16 3.2348087689060714 0.0012172422712508 7.157766990291262 15.730582524271844 1.3245491566248977 0.2112996285983387 3.5767402396348245 0.8689557679680192 1.477430451036954 0.2853006280851536 9.120885558043578e-08 0.0040679264544396 0.0008461128461095 8.369401706233654e-05 6.250068636960713e-09 +Mitochondrial protein containing complex 61 147 3.227271878493117 0.001249766495287 45.62621359223301 153.59708737864077 0.8032126729603613 0.4024101172023991 21.080430630469312 12.423857071229754 2.191669513941161 0.4117346592056412 1.5440790528707303e-14 2.795486742861714e-07 1.5405522545101905e-08 5.769896142550898e-11 1.997222838442068e-15 +Exocytic vesicle 17 35 3.176599127956262 0.0014901285421731 12.106796116504857 38.40533980582524 0.7408080162244459 0.4227017753873355 4.952517495270036 4.6543925000719675 1.3317240485888555 0.365166844745196 0.0486880945993073 0.4829170776296618 0.3721693300397056 0.2217261296268407 0.0577909974222632 +Nuclear outer membrane endoplasmic reticulum membrane network 168 313 3.1117035222928573 0.0018601120603098 98.3519417475728 305.0218446601942 1.8626549185660248 0.4346737740195964 40.114822105305365 33.029069404441934 2.648813561163414 0.4525721946789457 6.959889163272001e-44 0.0027161550783321 1.6724673336105126e-06 1.6306711482057753e-21 8.233792807613362e-44 +Transport vesicle 40 90 3.0887734187860585 0.0020098465859732 26.046116504854368 92.34708737864078 0.9512017428916244 0.4458616213657612 9.46815354334768 9.09007867686459 1.424803887648301 0.3967491654773343 0.004458061367771 0.3582794844835456 0.2367914149233073 0.0468162245270527 0.0062701869044127 +Snare complex 11 17 3.002670238455304 0.0026762224540146 6.20873786407767 15.79368932038835 0.8138466711937282 0.3737991711938105 3.1112263618988054 3.010283181947674 1.1802712183474584 0.3261149602927671 0.0461229939960997 1.0 0.0628860756551618 0.2718887634981339 0.0512129025413928 +Endoplasmic reticulum golgi intermediate compartment 20 47 2.958875689350441 0.0030876362630951 14.888349514563108 49.49271844660194 1.4759277407874345 0.3201471070907981 6.47003250199477 5.053350843348441 1.420924643396655 0.3585240832471577 3.771806611836951e-05 0.0012207780133923 0.0140771202759339 0.0086321321861891 5.287049766108464e-05 +Endoplasmic reticulum lumen 24 58 2.939959769587729 0.0032825486417111 18.07766990291262 59.737864077669904 0.9896277047863468 0.3946249358858228 7.513340007333169 6.273245958458151 1.4320597420402308 0.3846324865730224 0.0019777840695589 0.559981185156499 0.8038757761131052 0.0481841483511753 0.0026897518437372 +Organelle membrane contact site 11 18 2.93007736733698 0.0033887761965547 6.817961165048544 16.400485436893202 0.815819301321945 0.3904411977369264 3.451940177462974 2.047328298639296 1.2919706717077657 0.3464717655445403 2.5041343145606816e-06 0.1553991536419083 0.284754537798848 0.0090982869347887 3.567605275543363e-07 +Specific granule membrane 7 17 2.888129756152 0.0038753996802662 4.703883495145631 15.434466019417476 0.8701513897757543 0.3699585460258285 2.477017558764293 2.6655071934549124 0.9998631482292508 0.308737972868479 0.0016125551462254 0.2107016729382093 0.3746890061829235 0.0009997126365417 0.0019423634135914 +Intrinsic component of golgi membrane 6 9 2.8657333302390806 0.0041604454713757 4.655339805825243 10.08495145631068 1.3178763872097854 0.2129685736028588 2.6046347098798024 1.9780511021437377 1.2704958978874823 0.2699640456705705 0.0027726610526052 0.1835089509173778 0.0603249601752956 0.0171039247471448 0.0032683125169143 +Organelle subcompartment 200 378 2.7956183612284757 0.0051800529885817 115.97815533980582 370.4077669902912 1.8466078375892352 0.461199583276842 45.24176702976874 43.040100266333 2.697642340677977 0.4541841641473397 1.7149485506741392e-43 0.0017764075474253 5.4837735936047444e-08 6.292742250577452e-22 4.011803221578883e-43 +Mitochondrial envelope 147 310 2.747729594864328 0.0060009477512776 98.51456310679612 309.05582524271847 1.3784407074331837 0.4315621435689855 37.853540978552445 29.592036616547553 2.6690149272426917 0.4358105924461398 2.8103360291869456e-35 2.943869293728522e-13 1.0652365464059163e-14 1.3050369627589123e-25 3.5276656688233694e-36 +Microbody membrane 23 30 2.734742112683138 0.0062429165267055 9.83980582524272 26.8373786407767 1.0322166739723002 0.3740701224912098 5.101262737371427 4.075770333088885 1.3138416014090577 0.3534887732287703 0.0150694369255238 1.0 0.4209558173560673 0.1529222457430047 0.0051156872151014 +Proton transporting two sector atpase complex 8 22 2.7247971303030933 0.0064341007647601 7.116504854368932 22.25728155339806 1.0735578367707936 0.2848832687688338 3.2910616544032156 1.9833825153714253 1.32099194967518 0.2987458873835026 0.000759371118072 0.0005621116792476 0.0002868050489301 0.0011455603346848 0.0009037066514027 +Oxidoreductase complex 20 55 2.7216665303350704 0.0064953649497816 16.138349514563107 58.1747572815534 0.4112275970760134 0.4385210691837483 8.292749505639035 5.03902669070441 1.4297411393453454 0.366860872580609 1.5219548116838902e-05 0.0128377566891277 0.0028273486346575 0.0001480503499616 2.1889699767706857e-05 +Phagocytic vesicle membrane 14 26 2.7117251250303065 0.0066934072172397 7.512135922330097 23.83009708737864 0.5348434256443761 0.4468744105904624 3.681144332021715 3.0024693704800938 1.1652764437248655 0.3385441964418395 0.0212769263765699 1.0 0.4428019399824193 0.4268287237289989 0.0245338715183181 +Cytochrome complex 12 14 2.6538596658176288 0.0079576914148251 6.021844660194175 16.08495145631068 1.0267019648816196 0.2321293206617183 2.9315837025395948 1.6175814223208935 1.624269406530766 0.2919563386676546 0.001764656118099 0.0084566179175882 0.0025491163441 0.004610467719412 0.0020498103930161 +Nadh dehydrogenase complex 9 24 2.577180583927596 0.0099609896083032 7.419902912621359 23.609223300970875 0.690247022635013 0.3818090321561181 3.6908298840900926 3.1049932192976284 1.21822710313397 0.3228613418826432 2.875022417974631e-05 0.1952735388158895 0.0681167311872175 0.0006301512333158 3.698647282213466e-05 +Endoplasmic reticulum 219 479 2.564758481193563 0.0103247644794479 139.71116504854368 475.50728155339806 1.972579372344309 0.4597126503683645 50.29410175615224 47.94654634280014 2.8130551221954065 0.458598772128197 1.6668086091482283e-48 0.0012829219468262 4.582967556679667e-07 3.044510930401449e-22 7.606444063039865e-50 +Transport vesicle membrane 18 40 2.5634004296624333 0.0103652426812699 12.62135922330097 42.37378640776699 0.5402420874587609 0.5343084089707166 5.404271063272784 4.511161156897919 1.052801184280702 0.3556606283757049 0.0733617463480061 1.0 0.7108948051199993 0.3668173445101849 0.0853434756949824 +Mib complex 7 10 2.53310174841226 0.0113058130071606 4.669902912621359 10.016990291262136 0.8674199579421746 0.3102009046029466 2.3929035436504367 0.6011337749949848 1.2568635951567688 0.31203902687269 1.1945098500891429e-05 1.0 0.1169218221283287 0.0031665778749487 1.4142727101836116e-05 +Synaptic vesicle membrane 5 13 2.503877052363761 0.0122840712820158 5.099514563106796 14.07766990291262 0.7734258277348643 0.4227625879426745 2.579286376297321 2.2325453295101236 1.0485572818049853 0.3297289695807819 0.3081383298102741 1.0 0.4428019399824193 0.176085331764227 0.3273042981629884 +Pore complex 5 9 2.4937361932300983 0.0126406453023026 3.2111650485436893 8.830097087378642 1.029129610796519 0.2182996080526768 1.893158762220583 0.772882004264421 1.343874754683687 0.2717215815078918 7.357223468135498e-05 0.0029386578360865 0.0111011801010317 0.0005775014694085 8.66881295473223e-05 +Lipid droplet 10 33 2.4787501653147928 0.0131843618896465 7.313106796116505 30.72087378640777 0.9597061621709796 0.3916106255858687 3.663189105886808 2.181620314734523 1.1934081113966928 0.3497541884861006 0.0030596152653684 0.2731012734555347 0.0248074025314705 0.0046505532653846 0.0037202796455188 +Endoplasmic reticulum tubular network 6 12 2.454291162217715 0.0141162632014353 4.456310679611651 11.402912621359222 0.7597390036291544 0.4204688348420043 2.5600618129260964 1.9933849978482647 1.110800197793671 0.3406591463359876 0.0003644209238643 1.0 0.1898352204968973 0.4108142183097444 0.0004268250114145 +Copii coated er to golgi transport vesicle 16 33 2.4511427295699577 0.0142403474236594 10.810679611650484 32.4247572815534 0.9209697551014924 0.3949407296339237 5.01338814607213 3.9617918728777735 1.2509556054930144 0.3456813773327062 0.0033942797355807 0.2766173679843171 0.474050541733909 0.4748192031371173 0.0041222266067236 +Mitochondria associated endoplasmic reticulum membrane 6 9 2.446150164175825 0.0144390848104229 4.191747572815534 9.240291262135925 0.7019541594808174 0.4009163152547425 2.0831338076447135 1.0418560326821893 1.1194321867771957 0.3336055532093068 0.0001060978552471 1.0 1.0 1.0 1.0340338402060652e-05 +Proton transporting two sector atpase complex proton transporting domain 7 11 2.408618686426068 0.0160130187124984 4.053398058252427 10.283980582524272 1.020958321179617 0.2307004649223604 1.8491832641634656 1.1862626633334956 1.3576055733210162 0.273185751006507 0.0004123278641389 0.0022827689145391 0.0003495610743441 0.000343834728447 0.0004723549730038 +Intrinsic component of mitochondrial outer membrane 10 14 2.368209518176549 0.0178744103796448 5.004854368932039 12.186893203883496 0.537559322132711 0.4142348023165385 2.5976045215999015 2.144426747635188 1.2224430201503769 0.3320793466689031 0.0866531365642121 1.0 1.0 0.4248286628842983 0.0215080214882775 +Endocytic vesicle membrane 19 42 2.26813857638238 0.0233207617894455 11.41019417475728 40.75728155339806 0.6528171904926832 0.3529092384633215 4.825015011915381 4.780047567333447 1.5638167276319088 0.3380752375601685 0.0350157960153368 1.0 0.6624971528853236 0.5048945397535545 0.0414762283898676 +Cis golgi network 7 14 2.244919450351869 0.0247733040513233 5.446601941747573 14.91747572815534 1.304763677188147 0.2415633778835601 2.9087352716231463 3.2280604409731746 1.23405443481851 0.2890539664507128 0.5413752775777647 0.1715759324473242 0.0528695758908991 0.236499214653901 0.5575929441864913 +Golgi cisterna 13 21 2.2445787349930675 0.0247951891685289 8.524271844660195 22.490291262135923 0.9086972174309816 0.318868202549777 4.2525712614684625 5.269200019661922 1.391079392561209 0.3149122340418913 0.0184703272925716 1.0 0.5035637282775228 0.2502626974688664 0.0216262489604648 +Tim23 mitochondrial import inner membrane translocase complex 3 8 2.2319139233338072 0.0256206524824844 2.2694174757281553 6.342233009708738 1.5180442383336388 0.125307709046494 1.369833329272529 0.8106469094037756 1.2674744491900518 0.2021471972412396 0.0011263184466294 0.0012105019492812 0.0046590638338273 8.959563589527918e-05 0.001257434683291 +Nuclear inner membrane 14 21 2.230084118119611 0.0257418589805773 7.347087378640777 20.57281553398058 1.3204335588742686 0.2519451141048848 3.6006224195129035 1.9968516080603145 1.2188770932171689 0.2896682474252494 0.0027726610526052 1.0 0.3312162786192844 0.077109656392341 0.0032683125169143 +Trans golgi network membrane 13 30 2.213958343434504 0.0268316446430414 7.097087378640777 25.808252427184467 0.4300178223009387 0.4839581535123586 3.4857952056404495 4.861642003007495 1.0577526504941306 0.3235584371830635 0.004573331063426 0.2870659866655126 0.0043689110127226 0.0250782673402793 0.0055341168642902 +External side of plasma membrane 11 21 2.1807165147219827 0.0292043907739807 6.856796116504855 22.03640776699029 0.7617836494895279 0.3205100812766187 3.0547396608098576 3.343757364022431 1.3549821177336052 0.303342613906597 0.2151743199209392 1.0 1.0 0.9226635178830422 0.2365889615218201 +Respiratory chain complex iv 3 8 2.17839983945534 0.0293762818374947 3.754854368932039 9.74271844660194 0.8119042784517004 0.2590637228606872 2.032646352020888 1.0643473720992946 1.3870085883810457 0.2875864020654643 0.0080840699240292 0.083126337411673 0.1581956798045988 0.0668959947775429 0.0089558028351783 +Integral component of synaptic vesicle membrane 4 6 2.1523395658021114 0.0313706197530878 2.2475728155339807 4.910194174757281 0.8567274645780141 0.3149754325120096 1.3818760752746044 1.4445051429216968 1.1133243513780926 0.2989777184888048 0.0406693637652179 1.0 0.1500965904253892 0.0603828760130106 0.0437923930222569 +Azurophil granule 26 70 2.131241724150222 0.0330692332646944 20.46359223300971 67.00485436893204 0.4795255752980384 0.3097891700346699 6.177875864944045 5.290582926033595 2.1760997104513735 0.3628132485163926 1.0896254211040187e-06 0.4271480977769256 0.6689598947070614 0.0059936587630553 1.6916157986731542e-06 +Micos complex 4 5 2.117534724320924 0.0342144914758086 2.4927184466019416 4.725728155339806 0.7557668283408772 0.3464970141803932 1.2077602589329477 0.4877312285913208 1.1862461875397572 0.3249829583805667 0.0002668780103623 1.0 1.0 0.0142938954224823 0.0002989503611041 +Specific granule 10 36 2.1002710365614115 0.0357050055846606 8.742718446601941 34.25242718446602 0.2855678993885875 0.5987101990719559 3.996578681039245 4.349352025395783 0.8117156191720855 0.3097397590453908 0.0208520246808075 0.3498897642406863 0.5744906956895812 0.0190070308896292 0.0246729169005758 +Golgi apparatus subcompartment 37 87 2.0875853500987644 0.036835254637924 23.898058252427184 88.56796116504854 0.6438651907142603 0.5157075238910589 9.044082768463602 13.85685287398648 1.2182273227220288 0.3801323692583779 0.0037069117562108 0.379151373575087 0.0456208533934453 0.1153531597647382 0.0052916271531931 +Golgi lumen 3 6 2.062120883854804 0.0391962285523843 1.745679012345679 4.548148148148148 1.1368717941323 0.2457507117503182 1.2159484823715767 1.4039724163790972 1.161880305109492 0.2643265801751675 0.1807310432343384 1.0 0.2638774705145789 0.5369208791392233 0.1918739806034262 +Proton transporting v type atpase complex 5 12 2.0283818642767777 0.0425212895937552 3.1723300970873787 11.17233009708738 1.083137374920517 0.3054753623634815 1.8106779848505148 1.1913569842207026 0.9186852151104662 0.2868810804648729 0.006520727297513 0.0786913117950012 0.0111011801010317 0.0603828760130106 0.0072317525939857 +Intrinsic component of synaptic vesicle membrane 4 9 1.997568743212999 0.0457634347623692 3.648058252427184 9.116504854368932 0.724313202500786 0.4129003553732678 2.1933086936710184 1.7154408466980504 1.018214829869002 0.3297596143558817 0.1254226055028103 1.0 0.2277340705622599 0.133861047002827 0.1337634592725384 +Phagocytic vesicle 18 43 1.997256626371102 0.0457973124817794 11.54126213592233 41.59708737864078 0.3919256884663005 0.5681630099638236 4.854259100699266 4.0100348958770144 0.9938295058309184 0.3509625084864278 0.1765727423569479 1.0 0.6173373514131971 0.690867102221376 0.1012098308911812 +Mitochondrial intermembrane space protein transporter complex 3 5 1.9892556971379796 0.0466729870130147 1.2005141388174807 2.5167095115681235 0.6297728943083764 0.3036466482483842 1.011959204869136 1.1903007636326162 1.51035532787006 0.2968335314780513 0.0017428204603846 1.0 0.0557540441617295 0.1342523552784823 0.001897897013483 +Late endosome 22 67 1.9626556670259128 0.0496861977134626 15.655339805825244 65.18203883495146 0.1482522199608934 0.3683478922291265 6.675389202214119 9.543379127098556 1.7080817701484334 0.368772234437858 0.0270471361267826 0.0752674265862488 0.3096269152871024 0.0035522581613711 0.017580320168781 +Proton transporting atp synthase complex coupling factor f o 2 7 1.9605941910696167 0.0499263805517231 2.388349514563106 6.79126213592233 0.5842994650422648 0.284211882186535 1.5103719705721683 0.8950355849210965 1.3255228108854136 0.2674401609228611 0.0091083435026884 0.0009934566258862 0.0038356556834428 0.0014005858473499 0.0098775035556596 diff --git a/msigdb_gocc/metrics.json b/msigdb_gocc/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..3d93004ef3a5742d8c31d70c5736babe7bef5795 --- /dev/null +++ b/msigdb_gocc/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2974, + "annotations_size": 896, + "title": "Average number of proteins per term", + "value": 27.671875 +} \ No newline at end of file diff --git a/msigdb_gocc/paths.json b/msigdb_gocc/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..80fccb485df21df3181f7e61e7f2f2a35f941946 --- /dev/null +++ b/msigdb_gocc/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/msigdb_gocc/fragment/C220/C220_val_log2fc"} \ No newline at end of file diff --git a/msigdb_gocc/result.tsv b/msigdb_gocc/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..9076bc1bdb0f27c3c1fa57818ce3dc665d17cfb9 --- /dev/null +++ b/msigdb_gocc/result.tsv @@ -0,0 +1,253 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Intrinsic component of organelle membrane 0.7149214089926975 5.044894825718613 4.537709009875823e-07 0.0004064961775648 0.0003506937966609 134 Q99595,Q9Y2R0,Q53H12,O60830,P13473,Q15006,Q9Y282,Q13586,P20020,P01889,Q96NB2,Q99442,Q92643,Q15629,O60499,Q8N8Q8,Q8IWA4,Q15070,Q13505,O75844,Q9BTV4,Q8N2H4,Q9NQC3,Q86YN1,Q9HCU5,Q9UM00,Q6NTF9,Q9UH99,Q5XKP0,P12235,Q9H9B4,Q9P035,O95470,O14925,Q9H3K2,Q9H3H5,Q9NZ01,Q96A33,Q03518,Q9H490,P57105,Q9BUR5,Q14739,Q9GZP9,O76024,Q96AQ8,O43505,O43819,O75298,Q9BUN8,Q15041,O15118,Q8TB61,O15258,Q9HC21,Q9Y512,O95070,Q5SNT2,Q5J8M3,P10321,P57088,Q7L0J3,L0R6Q1,Q00325,Q86XL3,Q12981,Q9UG56,Q9NPA0,P42892,O00767,Q9Y5Y5,Q6Y1H2,Q9BWH2,Q9NX63,O43292,Q9Y4P3,O96008,Q9H9P8,Q5T9L3,P27824,Q9UBM7,P51572,Q6UXV4,Q15388,O75880,Q86Y82,O43808,Q6P4A7,P38646,P04439,Q16891 91 +Inner mitochondrial membrane protein complex 0.6567367814572362 4.939607782479695 7.827986532600596e-07 0.0007011419528713 0.0003506937966609 76 Q99595,Q9NX63,Q53H12,O60830,P13073,Q9Y512,P14406,O14925,Q86Y39,P00403,O96000,Q9UDW1,O75964,O95139,Q96DA6,Q8IYU8,Q9Y6M9,O43676,P00846,P51970,Q9BUR5,O75438,P35232,O14949,Q96CU9,Q6UXV4,P24539,Q13505,Q9Y5J7,Q9P0J0,P12236,O43674,P21912,P03886,P56385,P08574,Q5XKP0,O95168,Q9Y5J6,P38646,P22695,Q16891 42 +Intrinsic component of endoplasmic reticulum membrane 0.7004097347059842 4.822333618842412 1.4188836993772053e-06 0.0012705129107689 0.0004237732648809 55 O43292,O95470,Q9Y4P3,Q9H3H5,Q9NZ01,Q96A33,Q5J8M3,Q15006,P10321,Q9Y282,Q03518,Q13586,P01889,Q9H490,P57088,P27824,Q99442,Q86XL3,Q12981,Q92643,Q15629,Q9UBM7,P51572,Q9NPA0,O00767,Q9GZP9,O75844,O76024,Q9NQC3,O75298,Q9BUN8,Q86YN1,Q15041,Q9HCU5,Q6Y1H2,Q6NTF9,Q8TB61,Q9P035,P04439 39 +Intrinsic component of mitochondrial membrane 0.7175832450456903 4.644842475511403 3.4033603584227023e-06 0.0030447713235512 0.0007623527202869 49 Q99595,Q9NX63,Q53H12,Q9HC21,O60830,Q9Y2R0,Q9Y512,O14925,Q9H3K2,O96008,Q9H9P8,Q96NB2,P57105,Q9BUR5,Q00325,Q8N8Q8,Q9UG56,Q15070,Q6UXV4,Q13505,Q96AQ8,O43819,Q15388,O75880,Q5XKP0,Q9BWH2,P12235,Q6P4A7,P38646,Q16891 30 +Intrinsic component of plasma membrane 0.6174700064595566 4.546876524130303 5.444791946196403e-06 0.0048666660835522 0.0009757067167585 77 Q12907,O00400,Q9UJS0,O43657,Q8N2K0,O95864,P41440,O43464,P35670,Q9H0U3,Q8NHP6,O60637,P05023,P10321,Q9NPF0,P51790,P05141,Q13586,P20020,P01889,Q9H2J7,Q9UIQ6,P27824,P35613,Q00325,P35232,Q8TAD4,P51572,P33527,P11279,P53985,Q99805,O96005,P27105,P16615,O15498,P05067,Q9UNK0,O15118,O15121,Q15043,Q92542,P02786,Q99797,Q15758,P12235,Q9NR28,Q9H1Z9,P04439,O00264,Q8WTV0,Q08722 52 +Intrinsic component of mitochondrial inner membrane 0.7618995962279869 4.403021311389612 1.0675367477563924e-05 0.0095195794878584 0.001594188209983 33 Q99595,Q9NX63,Q53H12,Q9HC21,O60830,Q9Y2R0,Q9Y512,O14925,Q9H3K2,Q9H9P8,Q9BUR5,Q00325,Q8N8Q8,Q9UG56,Q15070,Q6UXV4,Q13505,Q96AQ8,O43819,O75880,Q5XKP0,Q6P4A7,P38646,Q16891 24 +Outer membrane 0.5742239844978275 3.98588531858676 6.722897942856854e-05 0.0584607006077258 0.008478366586914 90 O43169,Q9BVC6,Q9NUQ2,Q9NX63,Q8WY22,Q9Y512,Q9Y371,Q9Y277,Q8WWV3,P45880,O96008,Q9NQZ5,Q8N4H5,Q9NS69,P21796,Q9NZJ7,P30536,P57105,Q9BUR5,Q99720,Q9UBM7,Q9Y6C9,Q9NZ45,Q6UXV4,Q13505,Q6NUM9,Q8N2A8,Q86UT6,Q9UBF8,P52789,P50402,Q15388,O60313,P09601,Q5XKP0,Q9BWH2,P38646,O00264,Q16891 39 +Lysosomal lumen 0.6902660511465919 3.957621761587872 7.56997016688743e-05 0.0655802214916332 0.008478366586914 36 P54802,Q9UM22,P07858,P50897,P16278,O43681,P04062,Q9NZJ7,P07602,P17900,Q8IV08,Q8NHP8,P38435,O14773,Q9UMR5,P11117,P06280,P10253,Q13510,P10619,Q14108 21 +Endoplasmic reticulum protein containing complex 0.5433709872953923 3.776348429077811 0.0001591443286794 0.1329032061489722 0.0158437020552009 62 O15269,O43292,Q53GQ0,Q9H0U3,Q5J8M3,Q15006,Q03518,Q9Y5M8,O43681,P46977,Q9H490,O94888,Q92643,Q9NPA0,Q15005,Q9GZP9,Q9BUN8,Q15041,Q6NTF9,Q8WU17,P67812,Q9UBV2,P62942,P13674,P04439,P51571 26 +Secretory granule membrane 0.5317823328230679 3.716045694183862 0.0002023650006046 0.1658461234045549 0.0169482996091946 71 Q15363,P42785,Q96JJ7,Q9H0U3,P30519,P13473,Q8NHP6,P10321,O15260,P01889,Q9NV96,Q9NZJ7,P35613,P07602,Q8TAD4,P49755,Q06481,P11279,P27105,Q9NQX7,P61026,Q07065,P10253,Q969Q5,Q93050,Q4KMQ2,Q8NF37,O15121,Q92542,O00264,Q08722 31 +Organelle inner membrane 0.6406187681642525 3.7090106919947026 0.0002080706425235 0.1701005198939973 0.0169482996091946 238 Q99595,Q9Y2R0,Q53H12,O60830,P14406,Q9H061,Q9BRT2,Q69YU5,Q70HW3,Q9UBX3,Q9UDW1,O75964,Q9Y5L4,Q96DA6,P00846,O43676,Q96NB2,P51970,Q9H2D1,Q6PI78,Q9H936,Q9NRA0,Q8N8Q8,P35232,O14949,Q15070,Q13505,Q9Y5J7,Q567V2,Q5T9A4,Q8N5N7,O75844,Q9BTV4,Q6DKK2,O43674,Q3ZCQ8,Q9Y619,O75746,P03886,Q8N183,Q9BSK2,Q8IUX1,Q9UH99,Q5XKP0,Q9H1E5,P12235,Q9H9B4,P82933,P53701,Q9UDX5,Q99623,P13073,O14925,Q86Y39,Q9H3K2,Q13423,Q9BUR5,O75438,Q14739,Q9Y6C9,Q96CU9,Q9BQT8,P24539,P23786,Q9P0J0,P12236,Q96AQ8,P21912,O43819,Q8NBN7,O95202,O95674,Q9Y5J6,P22695,Q9HC21,Q9UJS0,Q9Y512,Q5SNT2,P00403,Q10713,O96000,P05141,O95139,Q9Y6M9,Q00325,P22830,Q9UG56,Q9NVI7,O75027,P50402,Q9BRJ2,Q8N6S5,O60313,Q86VD7,Q6NUK1,O95168,O75208,Q9NX63,Q9Y5J9,O96008,Q8WUK0,Q9H9P8,O43615,Q8IYU8,O95831,Q8WWC4,Q99720,Q6UXV4,P40939,Q7Z7H8,Q9UJZ1,P56385,O75880,P08574,Q6P4A7,P38646,P53007,Q16891 118 +Respirasome 0.6284516060547634 3.6090078926734583 0.0003073702591238 0.2407666359381739 0.0229503126812484 41 O95139,O14949,P13073,P14406,Q9Y6M9,O43676,Q9P0J0,Q86Y39,O75438,P00403,P21912,P22695,O96000,Q13423,Q9UDW1,P03886,Q96CU9 17 +Endoplasmic reticulum golgi intermediate compartment membrane 0.7092584099367966 3.5780284419697126 0.0003461957864452 0.2667328119844553 0.0238608788196101 24 Q15363,Q12907,O95070,Q8N511,Q10472,Q9Y282,Q03518,O15260,P24390,P49755,P51572,Q13190,Q9BVK6,O15498,Q9Y3B3,Q96RQ1,O75396,Q9H0U4,Q15904 19 +Azurophil granule membrane 0.6877390204156284 3.345071175309181 0.0008226145729959 0.5216277017432879 0.0463910120724691 22 O15260,P11279,P42785,Q8NF37,Q9NZJ7,P27105,Q92542,P07602,Q9H0U3,Q9NQX7,Q07065,P13473,P10253 13 +Transporter complex 0.5243697295640516 3.3431232649897167 0.0008284109298655 0.5241077470065942 0.0463910120724691 58 Q9C0H2,Q86Y39,Q8N2K0,Q9Y5J9,P05023,O96000,Q9UDW1,O95139,Q9Y5L4,Q9NV96,Q9Y6M9,O43676,Q8IYU8,O75438,O75381,O14949,Q96CU9,Q9Y5J7,Q9P0J0,P51798,P03886,Q4KMQ2,P08574,O95168,P62942,Q96S66,Q9Y5J6,P22695 28 +Golgi membrane 0.5427841446120902 3.299481438129292 0.000968636331295 0.5803435016118444 0.0510528325200225 130 Q96L58,Q15363,Q8IUH4,Q12907,P51151,O00400,O95070,O95197,Q9H7Z7,Q9H4A6,P35670,Q9Y371,Q10713,Q10472,P10321,Q9Y282,Q7LGA3,P52292,P51790,O15260,P24390,P01889,Q8IZA0,Q5T9L3,Q8N4A0,Q6NXT4,Q9HC07,Q15436,P35613,Q9BUR5,L0R6Q1,Q9NTJ5,Q8IV08,P40616,O60499,P49755,P51572,Q9BXS4,Q15392,Q9P2W9,Q8TBQ9,O00461,Q8NCH0,Q9Y3E0,Q8N2H4,Q13190,P61026,Q9UBF8,O43505,O15498,O95249,Q16739,Q9Y3B3,Q8NBN3,Q9UM00,Q8NF37,O75396,Q6NTF9,Q9H0U4,P62820,Q14108,P04439,Q8TB61,Q86Y82,Q96S66,O15258 66 +Vacuolar lumen 0.4863501506659023 3.2543053675161397 0.0011367002100333 0.6390669093766376 0.0559895389888609 67 P54802,Q9UM22,Q9H7Z7,P07858,P50897,Q9BTY2,P16278,O43681,P04062,Q9NZJ7,P07602,P17900,Q8IV08,Q8NHP8,P38435,O14773,Q9UMR5,P06865,P11117,P06280,P10253,Q13510,P10619,Q14108 24 +Outer mitochondrial membrane protein complex 0.7671480617518321 3.2348087689060714 0.0012172422712508 0.6642248052801563 0.0559895389888609 16 Q8N4H5,Q9NS69,Q13505,Q15388,Q9NX63,Q9Y512,Q9BUR5,Q5XKP0,P38646,O96008,Q16891,Q6UXV4 12 +Mitochondrial protein containing complex 0.548327158859385 3.227271878493117 0.001249766495287 0.6738804026413447 0.0559895389888609 147 Q99595,Q9NX63,Q53H12,O60830,P13073,P14406,Q9Y512,P09622,O14925,Q86Y39,P00403,Q9Y5J9,O96000,O96008,Q9UDW1,O75964,P05141,Q8N4H5,Q9NS69,O95139,P21796,Q9Y5L4,Q96DA6,P00846,Q9Y6M9,O43676,Q8IYU8,P51970,Q9BUR5,O75438,Q9HCC0,P11177,P35232,O14949,Q8IWA4,Q96CU9,Q6UXV4,Q13505,P24539,Q9Y5J7,Q567V2,Q8N5N7,Q96I99,Q9P0J0,P12236,P40939,O43674,P21912,Q7Z7H8,P03886,Q9BRJ2,Q15388,P56385,Q5XKP0,P08574,O95168,P12235,Q9Y5J6,P38646,P22695,Q16891 61 +Exocytic vesicle 0.5941517074699338 3.176599127956262 0.0014901285421731 0.7371445294621812 0.0635788177993864 35 P20020,P11279,Q12846,O15400,Q96A57,Q7L0J3,Q9BT78,Q92542,Q86Y82,O76024,P61026,O60499,P50897,P61421,Q9UI14,O43760,P51790 17 +Nuclear outer membrane endoplasmic reticulum membrane network 0.611026665417035 3.1117035222928573 0.0018601120603098 0.8114161264447883 0.0757572911835302 313 Q9BVC6,Q8N0U8,O95197,Q15800,Q92604,Q5VV42,Q969V3,Q8N511,Q8N2K0,P30519,O95772,O14735,Q15006,Q9Y282,Q13586,Q9Y5M8,P24390,P01889,Q15436,Q99442,Q86UE4,Q9NTJ5,Q8N5M9,Q9Y385,Q92643,Q15629,P49755,P43307,Q15392,Q9P2W9,P60059,Q9BQE5,O75844,P26885,Q9NQC3,P51648,Q9BRR6,Q86YN1,O75915,Q9HCU5,Q9UM00,Q8NF37,O75396,Q6NTF9,Q14108,Q8WU17,Q9H0U4,P09601,P67812,A1L0T0,Q9P035,O00264,Q9NUQ2,Q12907,O00400,P51151,P48651,Q96G23,O95470,Q96RL7,O60725,Q9H3H5,Q14849,Q9NZ01,Q96A33,O43464,Q8NHP6,Q9H4L5,O00560,Q4ZIN3,Q03518,Q15437,O15260,O75787,Q9H490,Q9HD20,O94888,P35613,Q92575,Q9BUR5,Q96HY6,Q14534,Q14739,Q16850,Q9BT22,P37268,Q9GZP9,O76024,Q07065,Q9BV10,O75298,Q9BUN8,Q15041,Q9NZ08,P27544,O15121,Q8TB61,Q6NUQ4,O95674,Q96N66,O15269,Q15363,P35610,O95070,Q53GQ0,Q9H3N1,Q96AA3,Q70UQ0,Q5J8M3,P10321,Q9H6H4,P46977,Q99735,P57088,Q86XL3,Q8IV08,Q12981,P38435,Q96PC5,Q9NPA0,O00767,Q8NHH9,Q9Y320,Q15005,P16615,P07099,Q13190,P61026,Q9Y5Y5,Q5BJF2,Q9Y3B3,P50402,Q6Y1H2,O14880,Q15904,Q06136,Q9UBV2,P62942,Q96S66,Q8IY17,P51571,O75477,O43292,Q96JJ7,Q9BU23,Q9Y4P3,O95864,Q9H0U3,Q10472,Q96AG4,P52292,Q96KC8,Q5T9L3,P27824,P16435,Q969M3,Q99720,Q9UBM7,P51572,Q2TAA5,O43852,Q6NUM9,Q9UBF8,Q9Y6I9,Q96RQ1,Q6UX53,Q9Y394,P04439 168 +Transport vesicle 0.4924315371984021 3.0887734187860585 0.0020098465859732 0.8351360446168434 0.0782966322187841 90 Q7Z6M1,Q15363,Q9NR31,O43493,P50897,Q9UI14,P10321,Q15437,P51790,O15260,P20020,P24390,P01889,Q9NV96,Q7L0J3,Q15436,O60499,P49755,P61421,P11279,Q12846,O15400,O00461,Q9BT78,Q13190,O76024,P61026,O15498,P05067,O95249,Q9GZM5,Q9Y3B3,Q96A57,O75396,P62820,Q9H0U4,Q92542,P04439,Q86Y82,O43760 40 +Snare complex 0.7085710507634845 3.002670238455304 0.0026762224540146 0.9093826611010482 0.0959158127518856 17 Q12846,Q9P2W9,O15400,O95219,Q86Y82,Q13190,Q12981,O60499,O15498,O95249,Q9UNK0 11 +Endoplasmic reticulum golgi intermediate compartment 0.5331624511032346 2.958875689350441 0.0030876362630951 0.9373882244446388 0.1047014990383814 47 Q15363,Q02818,O95070,Q8N511,Q10472,Q9Y282,Q03518,P80303,O15260,P24390,P51572,P49755,Q13190,O15498,Q9Y3B3,Q96RQ1,O75396,Q9H0U4,Q15904,O15258 20 +Endoplasmic reticulum lumen 0.4861373178124196 2.9399597695877295 0.0032825486417111 0.9474505910503924 0.1047014990383814 58 Q9Y680,Q02818,P10909,O43493,Q9BTY2,O14657,O43681,P27824,Q32P28,Q06481,O43852,Q96AY3,Q9H497,O95881,Q9BTV4,O76024,Q07065,Q9BV10,P05067,Q9NZ08,Q9NWM8,Q14257,P13674,O75718 24 +Organelle membrane contact site 0.677669155636315 2.9300773673369793 0.0033887761965547 0.9522368027909331 0.1047014990383814 18 Q15388,Q9Y320,P27824,Q5XKP0,Q14849,O95772,Q8NHP6,Q96S66,P51572,O96008,Q96N66 11 +Specific granule membrane 0.6900322930830445 2.888129756152 0.0038753996802662 0.969164971165734 0.1120115520489869 17 O15121,P27105,P30519,Q07065,Q8NHP6,O00264,Q08722 7 +Intrinsic component of golgi membrane 0.8734380755073354 2.8657333302390806 0.0041604454713757 0.9761396045173938 0.1164924731985204 9 O95070,Q9Y282,Q8TB61,Q8N2H4,O43505,O15258 6 +Organelle subcompartment 0.593908709827861 2.7956183612284753 0.0051800529885817 0.990470760016195 0.1326093565076917 378 Q9BVC6,Q8N0U8,O95197,Q15800,Q92604,Q5VV42,Q969V3,Q8N511,Q8N2K0,P30519,O95772,O14735,O43493,Q15006,Q9Y282,Q13586,Q9Y5M8,P24390,P01889,P04062,Q9Y3A3,Q9HC07,Q15436,Q99442,Q86UE4,Q9NTJ5,Q8N5M9,Q9Y385,Q92643,Q15629,O60499,P49755,P43307,Q15392,Q9P2W9,P60059,O00461,Q9BQE5,O75844,Q8N2H4,P26885,Q9NQC3,O15127,P51648,Q9BRR6,P05067,O95249,Q86YN1,O75915,Q9HCU5,Q8NBN3,Q96A57,Q9UM00,Q8NF37,O75396,Q6NTF9,Q14108,Q8WU17,Q9H0U4,P09601,P67812,A1L0T0,P53365,Q9P035,O00264,Q7Z6M1,Q9NUQ2,Q96L58,O00400,Q9BSR8,Q12907,P51151,Q96G23,O95470,P48651,Q96RL7,Q13636,O60725,P0CG08,Q9H3H5,Q14849,Q9NZ01,Q96A33,O43464,Q8NHP6,Q9H4L5,O00560,Q4ZIN3,Q03518,Q15437,O15260,O75787,Q9H490,Q9HD20,O94888,P35613,Q92575,Q9BUR5,Q96HY6,Q9UGP8,Q8TBA6,Q8N1B4,Q14534,Q14739,Q16850,Q9BT22,Q9BXS4,P37268,Q9GZP9,O76024,Q07065,Q9BV10,O75298,Q9BUN8,Q15041,Q9NZ08,P27544,O15121,Q8TB61,Q6NUQ4,O95674,Q96N66,O15269,Q15363,P35610,O95070,Q53GQ0,Q9H3N1,Q9H4A6,Q96AA3,Q70UQ0,Q10713,Q5J8M3,P10321,Q9H6H4,P46977,Q99735,P57088,Q9NX62,Q86XL3,Q8IV08,P40616,Q12981,P38435,Q96PC5,Q9NPA0,O00767,Q8NHH9,Q9Y320,Q15005,P16615,P07099,Q13190,P61026,Q9Y5Y5,Q5BJF2,Q9Y3B3,P50402,Q6Y1H2,O14880,Q15904,Q06136,Q9UBV2,P62942,Q96S66,Q8IY17,P51571,O75477,O43292,Q96JJ7,Q9BU23,Q9Y4P3,O95864,P35670,Q9H0U3,Q10472,Q00765,Q96AG4,P52292,Q96KC8,Q5T9L3,P27824,P16435,O14828,Q969M3,Q99720,Q9UBM7,P51572,Q2TAA5,Q12846,O43852,Q6NUM9,Q9UBF8,Q9Y6I9,Q9UNK0,Q96RQ1,Q6UX53,Q9Y394,P04439,Q4J6C6 200 +Mitochondrial envelope 0.5803665816663315 2.7477295948643277 0.0060009477512776 0.995451906364943 0.1332231037206202 310 O43169,Q99595,Q9Y2R0,O60830,Q96A26,Q8WY22,P14406,Q53H12,Q9H061,Q9BRT2,Q69YU5,Q70HW3,Q9UBX3,P45880,Q9UDW1,O75964,Q8N4H5,Q9NS69,P21796,Q9Y5L4,P00846,Q96DA6,O43676,Q8NBU5,Q96NB2,P51970,Q9H2D1,Q6PI78,Q9H936,Q9NRA0,Q8N8Q8,P35232,O14949,Q15070,Q9NZ45,Q8IWA4,Q13505,Q9Y5J7,Q567V2,Q8N2A8,Q5T9A4,Q8N5N7,Q6DKK2,O43674,Q3ZCQ8,Q9Y619,P03886,O75746,Q8N183,Q9BSK2,Q9BXK5,Q8IUX1,P09601,Q5XKP0,Q07820,P12235,P53701,Q9H9B4,P82933,Q9UDX5,O00264,Q99623,Q8NI60,Q9NUQ2,P13073,Q96RL7,O14925,Q86Y39,Q9H3K2,P10909,O00584,Q9Y277,Q8WWV3,Q13423,Q9NZJ7,P57105,Q9BUR5,O75438,Q9Y6C9,Q96CU9,Q9BQT8,P24539,P23786,Q86UT6,Q9P0J0,P12236,Q96AQ8,P21912,O43819,P52789,Q8NBN7,O95202,O15121,O95674,Q9NR28,Q9Y5J6,P22695,Q9HC21,Q9UJS0,Q9Y512,Q9H4A6,P00403,Q10713,O96000,Q9NQZ5,P05141,O95139,Q9Y6M9,Q00325,Q12981,P22830,Q9UG56,Q9Y320,Q96AY3,Q9NVI7,O75027,Q9BRJ2,O60313,Q86VD7,Q6NUK1,O95168,Q9BWH2,O75208,Q9NX63,Q9Y371,Q9Y5J9,O96008,Q8WUK0,Q9H9P8,O43615,Q8IYU8,O95831,P30536,Q8WWC4,Q6UXV4,P40939,Q9UBF8,Q7Z7H8,Q15388,Q9UJZ1,P56385,O75880,P08574,Q6P4A7,P38646,P53007,Q16891 147 +Microbody membrane 0.555447705452813 2.734742112683138 0.0062429165267055 0.996343272195467 0.1332231037206202 30 P39210,P04035,Q8NBU5,Q9BTZ2,O75381,O00116,P50542,Q6IAN0,Q8TB36,O95573,Q9BY49,Q9Y5Y5,Q9Y3D6,P51648,Q8WVX9,Q9NR77,Q15067,O43808,Q5T8D3,O75192,P28288,P40855,O15228 23 +Proton transporting two sector atpase complex 0.5991284281628264 2.7247971303030933 0.0064341007647601 0.9969223235662856 0.1332231037206202 22 Q93050,P24539,P00846,Q9Y487,P56385,Q15904,Q8N511,O75964 8 +Oxidoreductase complex 0.4788405387530557 2.7216665303350704 0.0064953649497816 0.9970877527847036 0.1332231037206202 55 O43169,P09622,Q86Y39,O96000,Q9UDW1,O95139,Q9Y6M9,O43676,P51970,O75438,P11177,O14949,Q96CU9,Q9P0J0,P21912,P03886,P08574,O95168,P13674,P22695 20 +Phagocytic vesicle membrane 0.5766685135458868 2.7117251250303065 0.0066934072172397 0.9975641366903452 0.1332231037206202 26 Q93050,Q06481,P11279,P01889,P51151,Q12846,O75396,Q9Y487,P61026,P13473,P61421,P10321,P04439,Q03518 14 +Cytochrome complex 0.7023166615472296 2.6538596658176288 0.0079576914148251 0.9992218664961086 0.1371171443785259 14 P14927,P13073,P14406,Q9Y276,P31930,P08574,O00483,P00403,P20674,P22695,O14949,Q9UDW1 12 +Nadh dehydrogenase complex 0.5695844172654307 2.577180583927596 0.0099609896083032 0.999872805766935 0.1601251283175492 24 O95139,Q9Y6M9,O43676,Q9P0J0,Q86Y39,O75438,O96000,P03886,Q96CU9 9 +Endoplasmic reticulum 0.5699997572767737 2.564758481193563 0.0103247644794479 0.9999084913818116 0.1601251283175492 479 Q9BVC6,Q9Y680,Q8N0U8,O95197,Q15800,Q92604,Q5VV42,Q969V3,Q8N511,Q8N2K0,P30519,O95772,O14735,O43493,Q15006,Q9Y282,Q9NPF0,P80303,Q13586,Q9Y5M8,P24390,P01889,Q01105,P04062,Q9NV96,Q15436,Q99442,Q86UE4,Q9NTJ5,Q8N5M9,Q9Y385,Q9H8H3,Q15629,Q9NRA0,Q92643,P49755,P43307,Q15392,Q32P28,Q16880,Q06481,O43390,Q9P2W9,O15173,P60059,Q9BQE5,Q9H497,O75844,Q9Y3E0,Q9BTV4,P26885,Q9NQC3,Q9H6V9,Q13510,P51648,Q9BRR6,O15498,P05067,Q86YN1,O75915,Q9HCU5,Q9UM00,Q96A57,P10619,Q8NF37,O75396,Q6NTF9,Q14108,Q8WU17,Q9NWM8,P09601,O95302,P67812,P62820,Q14257,A1L0T0,Q9P035,O00264,Q9NUQ2,Q8IUH4,O00400,Q02818,Q96G23,O95470,O60725,Q6ZXV5,Q9H3H5,Q14849,Q9NZ01,Q96A33,Q8NHP6,Q4ZIN3,Q03518,Q15437,Q96LJ7,O15260,Q9H490,Q9HD20,O94888,P35613,Q9BUR5,Q14534,Q14739,Q16850,Q9BT22,P37268,Q9GZP9,O76024,Q07065,Q9BV10,O75298,P52789,Q9BUN8,Q15041,Q9NZ08,P27544,O15118,O15121,Q92791,Q8TB61,Q99797,Q6NUQ4,O95674,P13674,O15258,Q96N66,O15269,Q15363,O75503,P35610,O95070,Q53GQ0,Q9H3N1,Q96AA3,Q70UQ0,Q5J8M3,Q9BTY2,P05023,P10321,Q9H6H4,P46977,Q99735,P57088,Q7L0J3,Q86XL3,Q8IV08,Q12981,P38435,Q96PC5,Q9H1A3,Q9NPA0,O00767,Q8NBQ5,Q8NHH9,Q9Y320,Q96AY3,Q15005,P27105,P16615,P07099,Q13190,P61026,Q9Y5Y5,Q5BJF2,Q9Y3B3,P50402,Q6Y1H2,O14880,Q15904,Q92542,Q06136,Q9UBV2,P62942,Q96S66,O75718,Q8IY17,P51571,O75477,Q9NR31,O43292,Q96JJ7,Q9BU23,Q9Y4P3,O95864,Q9H0U3,Q10472,Q00765,Q86YV9,Q96AG4,P52292,O14657,O43681,Q96KC8,Q5T9L3,P27824,P16435,P30536,Q9BRK5,Q969M3,Q99720,Q9UBM7,P51572,Q2TAA5,O43852,Q6NUM9,Q15631,O95881,Q15397,O60506,Q9UBF8,Q9UHB9,Q9Y6I9,Q9UNK0,Q8IY95,P55327,Q96RQ1,Q6UX53,Q9Y394,P04439 219 +Transport vesicle membrane 0.5112957393020467 2.5634004296624333 0.0103652426812699 0.9999117842456836 0.1601251283175492 40 Q9NR31,P20020,Q15363,P01889,Q9NV96,O75396,Q7L0J3,Q15436,Q13190,Q86Y82,O76024,O43760,O60499,P49755,P10321,P04439,Q15437,Q9Y3B3 18 +Mib complex 0.7665753682607858 2.53310174841226 0.0113058130071606 0.9999623699546776 0.168833474240265 10 Q13505,Q9NX63,Q9Y512,Q9BUR5,Q5XKP0,P38646,Q6UXV4 7 +Synaptic vesicle membrane 0.6931869871564927 2.5038770523637615 0.0122840712820158 0.9999845002882168 0.1763367921717938 13 Q7L0J3,Q86Y82,O76024,O60499,O43760 5 +Pore complex 0.7952540204359126 2.4937361932300983 0.0126406453023026 0.9999887844719154 0.1763367921717938 9 P21796,P12235,Q9Y277,P45880,P05141 5 +Lipid droplet 0.5157058759293012 2.4787501653147928 0.0131843618896465 0.999993153371752 0.1763367921717938 33 Q01105,Q8NBQ5,Q8NF37,Q07065,Q6UX53,Q9H8H3,Q99720,Q9H6V9,P51572,O43760 10 +Endoplasmic reticulum tubular network 0.6999815411144096 2.454291162217715 0.0141162632014353 0.9999970635036796 0.1796863887519306 12 P50402,Q9H6H4,Q8NHH9,P61026,Q9NQC3,Q00765 6 +Copii coated er to golgi transport vesicle 0.5125487518820084 2.4511427295699577 0.0142403474236594 0.9999973766852968 0.1796863887519306 33 Q15363,Q9NR31,P01889,P05067,Q96RQ1,O75396,O95070,Q15436,P04439,Q13190,Q969M3,P49755,P10321,Q9Y282,Q15437,Q9Y3B3 16 +Mitochondria associated endoplasmic reticulum membrane 0.7855081059287208 2.446150164175825 0.0144390848104229 0.9999978102675448 0.1796863887519306 9 Q9Y320,P27824,Q96S66,P51572,O96008,Q96N66 6 +Proton transporting two sector atpase complex proton transporting domain 0.7062940603074445 2.4086186864260677 0.0160130187124984 0.9999994770503896 0.1938873617080898 11 Q93050,P24539,P00846,Q9Y487,P56385,P61421,O75964 7 +Intrinsic component of mitochondrial outer membrane 0.654098594097395 2.368209518176549 0.0178744103796448 0.9999999041358808 0.2107298907916027 14 P50416,Q8IXI1,Q15388,P57105,O95140,Q9UH62,Q9BWH2,Q9Y3D6,O96008,Q8IWA4 10 +Endocytic vesicle membrane 0.4752589200155617 2.2681385763823796 0.0233207617894455 0.999999999342717 0.2321711395927021 42 P51151,O43493,P13473,P10321,Q03518,P01889,Q5T9L3,P61421,Q06481,P11279,Q12846,Q9Y487,P61026,Q93050,O75396,Q14108,P02786,P04439,Q8WTV0 19 +Cis golgi network 0.6337877773663053 2.244919450351869 0.0247733040513233 0.9999999998267788 0.2328871231754525 14 P24390,Q14789,O00461,Q8TBA6,Q8WVM8,P49755,O95249 7 +Golgi cisterna 0.5386046766610886 2.2445787349930675 0.0247951891685289 0.9999999998302272 0.2328871231754525 21 Q96L58,Q15363,Q8NBN3,Q9Y3A3,O00461,P04439,P0CG08,Q9H4A6,Q10713,Q10472,P51572,Q9BXS4,O95249 13 +Tim23 mitochondrial import inner membrane translocase complex 0.7754893198564969 2.2319139233338072 0.0256206524824844 0.9999999999205028 0.2353541392509928 8 Q99595,O14925,O60830 3 +Nuclear inner membrane 0.5366926803125655 2.230084118119611 0.0257418589805773 0.999999999928888 0.2353541392509928 21 P50402,P43243,Q8N6S5,Q03252,Q5SNT2,Q9UH99,O75844,Q9BTV4,P20700,P62995,Q9H1E5,Q99720,Q14739,O94901 14 +Trans golgi network membrane 0.4938302831171547 2.2139583434345034 0.0268316446430414 0.9999999999739128 0.2403057305547423 30 Q7Z6M1,P51151,Q13636,Q9HC07,Q9NX62,P35670,Q8N2H4,P40616,P53365,O14828,O15127,O60499,P05067 13 +External side of plasma membrane 0.5302038951914578 2.1807165147219827 0.0292043907739807 0.9999999999970725 0.2414784268476632 21 P08183,P11279,P42892,P51790,O96005,P41440,P49327,P02786,P04083,P07858,O75955 11 +Respiratory chain complex iv 0.7643398824346628 2.17839983945534 0.0293762818374947 0.999999999997502 0.2414784268476632 8 P22695,P13073,P14406 3 +Integral component of synaptic vesicle membrane 0.7864704639547947 2.1523395658021114 0.0313706197530878 0.9999999999996044 0.253225903592493 6 Q86Y82,Q7L0J3,O76024,O60499 4 +Azurophil granule 0.3955141319379167 2.131241724150222 0.0330692332646944 0.999999999999918 0.2622126814616481 70 P42785,Q9H7Z7,O00584,Q9H0U3,P13473,Q9BTY2,O00560,P16278,O15260,O43681,Q9NV96,Q9NZJ7,P07602,P17900,P04066,P11279,O15400,P27105,P06865,Q9NQX7,P06280,Q07065,P10253,P10619,Q8NF37,Q92542 26 +Micos complex 0.8295722465476589 2.1175347243209237 0.0342144914758086 0.9999999999999716 0.2665091363350421 5 Q6UXV4,Q9NX63,Q9BUR5,Q5XKP0 4 +Specific granule 0.4690654858664795 2.1002710365614115 0.0357050055846606 0.9999999999999928 0.2711159746089484 36 Q12846,Q4KMQ2,O15121,P27105,P30519,Q07065,Q8NHP6,Q08722,O00264,P51790 10 +Golgi apparatus subcompartment 0.406781098197792 2.0875853500987644 0.036835254637924 0.9999999999999976 0.2750365679631661 87 Q7Z6M1,Q96L58,Q9BSR8,P51151,Q15363,Q13636,P0CG08,Q9H4A6,P35670,O43493,Q10713,Q10472,P04062,Q9Y3A3,Q5T9L3,Q9HC07,Q9NX62,Q8TBA6,P40616,O14828,Q969M3,O60499,P51572,Q9BXS4,Q12846,O00461,Q8N2H4,P61026,O15127,P05067,O95249,Q9UNK0,Q8NBN3,Q96A57,P53365,P04439,Q4J6C6 37 +Golgi lumen 0.767047189579744 2.0621208838548037 0.0391962285523843 0.9999999999999998 0.2779124424658863 6 O00461,Q9NX62,Q9BRK5 3 +Proton transporting v type atpase complex 0.6258220846478328 2.0283818642767777 0.0425212895937552 1.0 0.2908326372214098 12 Q93050,Q9Y487,Q15904,Q8N511,P61421 5 +Intrinsic component of synaptic vesicle membrane 0.6962911425513608 1.997568743212999 0.0457634347623692 1.0 0.3039584591383286 9 Q86Y82,Q7L0J3,O76024,O60499 4 +Phagocytic vesicle 0.4455207900336663 1.997256626371102 0.0457973124817794 1.0 0.3039584591383286 43 Q93050,Q06481,P11279,P51151,P01889,Q12846,O75396,Q9Y487,Q9UNK0,Q86Y82,P61026,P13473,P08670,P61421,P10321,P04439,Q03518,P51790 18 +Mitochondrial intermembrane space protein transporter complex 0.8007719439061067 1.9892556971379791 0.0466729870130147 1.0 0.307492620321038 5 Q9Y5J9,Q9Y5J6,Q9Y5J7 3 +Late endosome 0.3796758595169821 1.9626556670259128 0.0496861977134626 1.0 0.3127788032287759 67 P35670,Q14849,O95772,P13473,Q9P253,P51790,Q9NV96,Q9NZJ7,Q9HC07,P07602,Q9BRK5,Q8IV08,Q9BXS4,P11279,Q9GZP9,Q9BUN8,Q9UNK0,Q8IY95,Q96A57,O15118,Q14108,Q15043 22 +Proton transporting atp synthase complex coupling factor f o 0.7326064558542061 1.9605941910696172 0.0499263805517231 1.0 0.3127788032287759 7 P00846,O75964 2 +Mitochondrial permeability transition pore complex 0.8546459248081489 1.9338649232312084 0.0531297378420869 1.0 0.3127788032287759 4 P21796,P12235 2 +Hrd1p ubiquitin ligase erad l complex 0.7814268458722448 1.9021543076132268 0.0571509843615904 1.0 0.322058377282925 5 Q6NTF9,Q9GZP9,Q9BUN8 3 +Er ubiquitin ligase complex 0.7814268458722448 1.9021543076132268 0.0571509843615904 1.0 0.322058377282925 5 Q6NTF9,Q9GZP9,Q9BUN8 3 +Organelle envelope lumen 0.442532749915758 1.892838149839828 0.0583793964741992 1.0 0.3269246202555155 39 Q53H12,O14925,Q9H4A6,O00584,Q9BRT2,O43464,Q9Y5J9,Q9Y5L4,Q8IYU8,O95831,P51970,Q9Y5J7,Q96AY3,P05067,Q9HB71,O60313,Q9UJZ1,Q9NR28,Q9Y5J6,Q16891 20 +Respiratory chain complex iii 0.7081226828446036 1.841735981881484 0.0655137782667507 1.0 0.3536165381145101 7 P14927,P31930,P08574,P22695,O14949,Q9UDW1 6 +Golgi medial cisterna 0.7662188224401788 1.8331681118846468 0.0667775744851104 1.0 0.3540396848441359 5 Q9BXS4,P04439,O95249 3 +Proton transporting atp synthase complex 0.630744356298071 1.8102673262714255 0.0702543413652545 1.0 0.3643365852402951 10 P00846,O75964 2 +Er to golgi transport vesicle membrane 0.4816408513903392 1.8025702571823428 0.0714557316142816 1.0 0.3643365852402951 21 Q15363,Q9NR31,P01889,Q15436,Q13190,P49755,P10321,P04439,Q15437,Q9Y3B3 10 +Membrane protein complex 0.4976611629240931 1.7931406917198136 0.0729504305105133 1.0 0.3643365852402951 284 Q99595,Q53H12,O60830,Q9Y5X3,P14406,Q9C0H2,Q8N2K0,Q8N511,P41440,Q15006,P45880,Q9P253,Q9UDW1,O75964,Q8N4H5,Q9NS69,Q9Y5M8,P01889,P21796,Q96DA6,P00846,O43676,P51970,Q15436,Q92643,O60499,P35232,O14949,P49755,P61421,Q8IWA4,Q13505,Q9P2W9,O15400,P60059,Q9Y5J7,O43674,Q07666,Q3ZCQ8,O15498,O95249,P03886,Q93050,O75396,Q6NTF9,Q8WU17,Q9UH99,P67812,Q5XKP0,P12235,P13073,O14925,Q86Y39,Q9Y277,Q03518,Q15437,Q9H490,O94888,Q9BUR5,O75438,Q96CU9,P24539,Q9P0J0,Q9GZP9,P12236,P21912,Q9BUN8,Q15041,Q9NR28,Q9Y5J6,P22695,O15269,Q9Y512,Q53GQ0,P00403,Q5J8M3,P05023,O96000,P10321,P05141,O95139,P46977,Q9Y6M9,Q12981,Q9NPA0,Q9Y487,Q15005,Q13190,P49327,Q9Y3B3,Q4KMQ2,Q15904,Q92542,O95168,Q9UBV2,P62942,Q96S66,P51571,Q9NR31,Q9NX63,O43292,Q9H0U3,O96008,O75955,Q8IYU8,Q6UXV4,Q12846,P51798,Q9UNK0,Q15388,P56385,O95219,P08574,Q86Y82,P38646,P04439,Q16891 117 +Vacuolar membrane 0.4134997920825476 1.7745483813145564 0.0759724867884197 1.0 0.3679532333104004 127 O75503,P42785,Q8N511,P41440,Q14849,O95772,Q9H0U3,P13473,Q9Y371,Q86YV9,Q9P253,P51790,O75955,O15260,Q9UIQ6,P04062,Q9NV96,Q9NZJ7,Q9HC07,P07602,Q8IV08,Q9NRA0,P61421,Q9BXS4,P11279,P42892,Q9Y487,P27105,P11117,Q9NQX7,Q07065,P51798,P10253,Q9Y6I9,Q9UNK0,Q93050,Q8IY95,P10619,O15118,Q8NF37,Q14108,Q15043,Q92542,Q8WTV0 44 +Trans golgi network 0.3624542797145832 1.7612052386198085 0.0782036717190319 1.0 0.3740409901220871 65 Q7Z6M1,Q9BSR8,P51151,Q9H4A6,P35670,O43493,P04062,Q5T9L3,Q9HC07,Q9NX62,P40616,O14828,Q969M3,O60499,Q12846,Q8N2H4,P61026,O15127,P05067,Q9UNK0,Q96A57,P53365,Q4J6C6 23 +Golgi stack 0.4557037400352165 1.7595636760946098 0.0784818148916879 1.0 0.3740409901220871 27 Q96L58,Q15363,Q8NBN3,Q9Y3A3,O00461,P04439,P0CG08,Q9H4A6,Q10713,Q10472,P51572,Q9BXS4,O95249 13 +Platelet alpha granule 0.5178197260081944 1.7431649509147336 0.0813048058040071 1.0 0.3761487153935791 17 Q8NBX0,Q06481,Q96JJ7,P51809,P10909,Q9NTK5,Q9NUQ9,P05067,Q9Y6I9,Q6UXV4 10 +Tim22 mitochondrial import inner membrane insertion complex 0.808743983152287 1.7375931284217765 0.0822825314923454 1.0 0.3761487153935791 4 Q9Y5J6,Q9Y5J7 2 +Endosome lumen 0.7429576520014338 1.7268161156572863 0.0842006932705314 1.0 0.3791146792482222 5 P05067,P07858,Q9UIQ6 3 +Triglyceride rich plasma lipoprotein particle 0.9417900403768528 1.718364409205356 0.0857301678502908 1.0 0.384071151969303 2 Q9UHG3 1 +Lumenal side of membrane 0.6081955281049661 1.6845217700829376 0.0920808757947342 1.0 0.4005071102528246 10 P01889,P10619,P27824,P51572,P10321,P04439 6 +Rough endoplasmic reticulum membrane 0.5065131659259424 1.662737239649164 0.0963650443791943 1.0 0.4125235943333052 17 Q15041,Q9Y5M8,P60059,Q96A33,Q9UBF8,Q5BJF2,P51571 7 +Membrane microdomain 0.3703985329823673 1.6460658146091625 0.0997502096681786 1.0 0.4166043652693276 59 Q13586,P21796,O14773,O15118,O75955,Q9UJZ1,P35613,P27105,P09601,Q86Y82,P41440,P49327,P13473,P30154,P50897,P05023,Q8WTV0,P05141 18 +Emc complex 0.7848240147066874 1.6341277078888057 0.1022320379985617 1.0 0.4174382555190911 4 Q9NPA0,Q5J8M3 2 +Platelet alpha granule lumen 0.5706675813129793 1.6335073245993732 0.1023623414968497 1.0 0.4174382555190911 11 Q8NBX0,Q9NUQ9,Q9NTK5,P05067,Q9Y6I9,Q6UXV4 6 +Apical plasma membrane 0.407076647404467 1.6233986995341425 0.1045042025463562 1.0 0.4174382555190911 44 P41440,P07858,P05023,O75955,P51790,P20020,O75787,Q9NV96,Q86UE4,Q8TAD4,P61421,P33527,P08183,P53985,Q9Y6M7,Q16625,Q15043,P04083,Q99797 19 +Recycling endosome 0.4126228827577531 1.5964511487948303 0.1103881042121142 1.0 0.4300336581480623 39 P01889,O15400,O14773,Q96A57,Q8N668,Q9UNK0,Q86Y82,P02786,P61026,O14828,O15127,P05067,P10321,P04439,P51790 15 +Haus complex 0.7750841750841677 1.5917930956381796 0.1114312020268699 1.0 0.4322179957405865 4 O94927,Q96CS2,Q9H6D7 3 +Cell surface 0.3571655151059156 1.5870255704720244 0.1125068534100708 1.0 0.4327114495941975 74 Q12907,Q96JJ7,P10909,P41440,P07858,P10321,P51790,O75955,P01889,P35232,P08183,P11279,P42892,P14174,Q12846,O96005,P49327,Q07021,P05067,O75298,Q4KMQ2,P04439,P02786,P04083,O15258,Q99623,Q8WTV0,Q08722 28 +Vacuolar proton transporting v type atpase v0 domain 0.7734006734006805 1.5844645591738615 0.1130880405785226 1.0 0.4327114495941975 4 Q93050,Q9Y487,P61421 3 +Proton transporting v type atpase v0 domain 0.7734006734006805 1.5844645591738615 0.1130880405785226 1.0 0.4327114495941975 4 Q93050,Q9Y487,P61421 3 +Chloride channel complex 0.6662743063038461 1.5800731428239965 0.1140901170344679 1.0 0.4327114495941975 6 Q9C0H2,Q4KMQ2,Q96S66 3 +Prespliceosome 0.5599547993359415 1.5695353997554224 0.1165232376531399 1.0 0.4333356171102963 11 Q9UK45 1 +Golgi associated vesicle membrane 0.4811979547439461 1.5693960933142814 0.1165556737986399 1.0 0.4333356171102963 18 Q8N511,Q15363,Q8IUH4,P24390 4 +Pigment granule 0.3602622777970864 1.5600318211843631 0.1187523615660899 1.0 0.4394369703482344 60 P51151,P41440,P07858,P05023,O75955,P57088,P27824,P35613,P49755,P11279,O43852,O14773,P27105,P49327,Q93050,O75396,P62820,Q92542,P02786,Q15758,P55209 21 +Anaphase promoting complex 0.5576463401887354 1.5557031634205492 0.1197786940045009 1.0 0.4394369703482344 11 Q13042,Q9UJX6,Q96DE5,Q9UJX4,O60566,Q9UJX3 6 +Golgi cisterna membrane 0.5015478819667922 1.543377361680956 0.1227392431445419 1.0 0.4400549828749533 16 Q96L58,Q15363,Q8NBN3,Q9Y3A3,O00461,Q9H4A6,Q10713,Q10472,P51572 9 +Translocon complex 0.703263423235026 1.543196120376316 0.1227831983468061 1.0 0.4400549828749533 5 Q15041,P51571,P60059 3 +Gpi anchor transamidase complex 0.6999536434921376 1.5277764892611043 0.1265680415003118 1.0 0.4500197031122199 5 Q9H490,O43292 2 +Envelope 0.4994714168056714 1.5183347360768642 0.1289300351546554 1.0 0.4549855207773381 474 O43169,Q99595,Q9BVC6,Q9Y2R0,O60830,Q96A26,Q8WY22,P14406,Q53H12,Q96P70,Q9H061,Q9BRT2,Q69YU5,Q70HW3,Q9UBX3,P45880,Q9UDW1,O75964,P80303,Q8N4H5,Q9NS69,P21796,Q9Y5L4,P00846,Q96DA6,O43676,Q8NBU5,Q96NB2,P51970,Q9H2D1,P41208,Q6PI78,Q9H936,Q86UE4,Q9NRA0,Q8N8Q8,P35232,O14949,Q15070,Q9NZ45,Q8IWA4,Q13505,O15173,Q9Y5J7,P78406,Q567V2,Q8N2A8,Q5T9A4,Q8N5N7,Q9H497,O75844,Q9BTV4,Q6DKK2,Q9NQC3,O43674,Q3ZCQ8,P05067,Q9Y619,P03886,O75746,Q8N183,Q9BSK2,Q9BXK5,Q8IUX1,Q9UH99,P09601,Q5XKP0,Q07820,Q9H1E5,P12235,P53701,Q9H9B4,P82933,Q9P035,Q9UDX5,O00264,Q99623,Q8NI60,Q9NUQ2,P13073,Q96RL7,O14925,Q86Y39,Q9H3K2,P10909,O00584,O43464,Q9Y277,Q8WWV3,Q9H4L5,O00560,Q13423,Q9P0S9,O43772,Q9BTX1,Q9NZJ7,P31930,Q92575,P57105,Q9BUR5,O75438,Q9BW91,Q8NFH5,O00483,Q14739,Q9BYT8,Q9UBU9,Q9Y6C9,Q96CU9,Q9BQT8,Q02978,P24539,P23786,Q86UT6,Q9P0J0,P12236,Q96AQ8,P21912,O43819,P52789,P42167,Q8NBN7,O15118,O95202,O15121,O95674,Q9NR28,Q9Y5J6,P22695,Q9HC21,Q9UJS0,Q9Y512,Q5SNT2,Q9H4A6,P00403,Q10713,O96000,Q9NQZ5,P05141,O95139,O00505,Q99735,P57088,Q9Y6M9,Q00325,Q12981,P22830,Q9UG56,Q9Y320,Q96AY3,Q9NVI7,O75027,Q5BJF2,P50402,Q9BRJ2,Q8N6S5,O14880,O60313,Q86VD7,Q6NUK1,O95168,Q9BWH2,Q96S66,O75208,Q9NX63,Q9Y371,Q9Y5J9,Q96AG4,O96008,Q8WUK0,Q9H9P8,O14657,O43615,Q96KC8,Q8IYU8,O95831,P30536,Q8WWC4,Q99720,Q9UBM7,Q6UXV4,Q6NUM9,P40939,Q9UBF8,Q7Z7H8,Q15388,Q9UJZ1,P56385,O75880,P08574,Q9HB71,Q6P4A7,P38646,P53007,Q16891 195 +Rough endoplasmic reticulum 0.408779962375936 1.5119061298147654 0.1305577444308909 1.0 0.4568034090629254 35 Q15041,Q9Y5M8,P60059,P27824,Q5VV42,Q99442,Q07065,Q96A33,Q9UBF8,Q5BJF2,P51571 11 +Oligosaccharyltransferase complex 0.6303697123536998 1.5100245748076024 0.1310371536412504 1.0 0.4568034090629254 8 Q9H0U3,P04843,Q8TCJ2,P46977 4 +Mitochondrial proton transporting atp synthase complex coupling factor f o 0.6928556850066485 1.494658027015356 0.1350037137509585 1.0 0.4589430157457318 5 P24539,O75964 2 +Signal peptidase complex 0.8889636608344598 1.4938138464655526 0.1352242814250817 1.0 0.4589430157457318 2 P67812 1 +Coated vesicle 0.3554705377603446 1.4630736362343146 0.1434472308989201 1.0 0.4670471053385114 83 Q15363,Q9NR31,O95070,Q8N511,O43493,P10321,Q9Y282,Q9P253,Q15437,P24390,P01889,Q15436,Q969M3,P49755,P51572,P42892,Q5VW38,Q13190,P05067,Q9Y3B3,Q96RQ1,O75396,Q14108,P02786,P04439 25 +Sec61 translocon complex 0.7451283175529676 1.460953896821246 0.1440280940421621 1.0 0.4670471053385114 4 Q15041 1 +Proteasome core complex beta subunit complex 0.6302156470542 1.454373753809473 0.1458427125228834 1.0 0.4691422506831429 7 P49721,P28070,P28072,P28074 4 +Derlin 1 retrotranslocation complex 0.6790224452802354 1.4299298003561285 0.1527371680214595 1.0 0.4829995013440324 5 Q8WU17,Q9BUN8 2 +Intrinsic component of nuclear inner membrane 0.6245993249722933 1.4259761190900209 0.1538752354747838 1.0 0.4832683509029094 7 Q14739,Q5SNT2,Q9UH99,Q9BTV4 4 +Early endosome 0.3605883162261429 1.4116313795548667 0.1580585278457125 1.0 0.4906459566441528 94 Q9Y5X3,Q8N668,P41440,Q86YV9,P10321,Q9P253,P51790,O75955,P01889,Q9UIQ6,Q9NV96,Q5T9L3,Q9HC07,Q8IV08,P35232,P61421,Q92544,Q06481,O15400,Q5VW38,Q9GZP9,Q13510,P05067,Q96J02,Q9BUN8,Q9UNK0,Q96A57,P62820,Q15043,Q92542,O95219,Q86Y82,P02786,P04083,P04439 35 +Copi coated vesicle membrane 0.5239413290762337 1.409598252674446 0.1586583432571242 1.0 0.4906459566441528 12 Q8N511,Q15363,P24390 3 +Intrinsic component of peroxisomal membrane 0.6685752778713362 1.3809026052081297 0.1673089088261468 1.0 0.5098938173749236 5 Q9Y5Y5,O43808,O75192,Q9Y3D6 4 +Early endosome membrane 0.3779839211600272 1.3717319055908797 0.170146912192014 1.0 0.511752167202752 47 Q06481,P01889,Q9Y5X3,Q9NV96,Q5T9L3,Q15043,Q9HC07,O95219,P04439,Q86Y82,Q8IV08,P04083,Q86YV9,P10321,Q96J02,P51790 16 +Apical part of cell 0.3591276775294668 1.363837858240752 0.1726186022294171 1.0 0.5148910343464063 55 Q99538,P41440,P07858,P05023,P51790,O75955,P20020,O75787,Q9NV96,P41208,P54709,Q86UE4,Q15154,Q8TAD4,P61421,P33527,P08183,P53985,Q9Y6M7,P36551,P05067,P21283,Q14254,Q16625,Q15043,P04083,Q99797 27 +Presynaptic active zone 0.4731785230857532 1.3436303137720138 0.1790679618894728 1.0 0.5221164631418489 16 Q12846,P20020,P27824,Q7L0J3,P41440,Q07021,P05067,O75955 8 +Zymogen granule membrane 0.71305374096695 1.3200650699258898 0.1868132937580755 1.0 0.5347754351668872 4 Q15363 1 +Cytoplasmic ubiquitin ligase complex 0.5920839342923753 1.311454245491284 0.1897043422461781 1.0 0.5356665452395675 8 Q6NTF9,Q9GZP9,Q9BUN8 3 +Phagocytic cup 0.6516545201422306 1.3012835894798884 0.1931614022953218 1.0 0.5376860522142207 5 P04083,Q9Y5X3 2 +Secondary lysosome 0.7002161197588792 1.2635449263456922 0.2063934116472867 1.0 0.5540063162673834 4 P11279 1 +Autolysosome 0.7002161197588792 1.2635449263456922 0.2063934116472867 1.0 0.5540063162673834 4 P11279 1 +Endoplasmic reticulum quality control compartment 0.6017595020099085 1.261160795019988 0.207250920521945 1.0 0.5540063162673834 6 Q8WU17,Q9BUN8 2 +Nucleoid 0.3846074842644976 1.2598356700012563 0.2077286491660257 1.0 0.5540063162673834 33 P34897,P06576,P21796,O00411,P49411,Q04837,Q9BRT2,Q9Y2S7,P36776,Q00059,P40939,P38646,Q9NUL7,Q9NVI7,Q96AG4,P45880,P05141 17 +Recycling endosome membrane 0.4142066967993356 1.253817761570924 0.2099082518112227 1.0 0.5540063162673834 21 P01889,Q86Y82,P61026,O14828,O15127,P10321,P04439 7 +Copi coated vesicle 0.4888275574177252 1.247857223501188 0.212083348295041 1.0 0.5540063162673834 13 Q8N511,Q15363,P24390 3 +Protein lipid complex 0.695506184758985 1.2428013781544758 0.2139410345577348 1.0 0.5540063162673834 4 Q9UHG3 1 +Photoreceptor inner segment 0.6371540436704903 1.2329015730149993 0.2176124885147841 1.0 0.5540063162673834 5 P35613 1 +Lumenal side of endoplasmic reticulum membrane 0.5862979943700605 1.2310709694486732 0.2182963221348557 1.0 0.5540063162673834 7 P27824,P51572,P10321,P04439 4 +Endoplasmic reticulum tubular network membrane 0.8286077401519667 1.2166176579771484 0.2237497211342787 1.0 0.5599993020567422 3 Q9NQC3 1 +Dopaminergic synapse 0.8223418573351293 1.210759318315086 0.2259876608659889 1.0 0.5624581781553504 2 O75955 1 +Intrinsic component of vacuolar membrane 0.8209959623149461 1.2050726959340388 0.2281752392941949 1.0 0.5638111171389307 2 O15118 1 +Basal part of cell 0.3668876684903092 1.1946003917748638 0.2322431961132085 1.0 0.5654616948843338 44 P20020,P42785,Q12846,P33527,P53985,Q15043,P35613,P57105,P35670,P41440,P02786,P04083,P05023,Q6P4Q7,O75955 15 +Basolateral plasma membrane 0.3746296543124724 1.189011840338709 0.2344350076859036 1.0 0.5692514007766115 37 Q12846,P53985,P33527,Q15043,P35613,P57105,P35670,P41440,P04083,P05023,Q6P4Q7,O75955 12 +Nuclear ubiquitin ligase complex 0.4766810299434598 1.168767013909014 0.2424975137854881 1.0 0.577936069644428 13 Q13042,Q9UJX6,Q96DE5,Q9UJX4,O60566,Q9UJX3 6 +Mhc class i protein complex 0.8165600807808747 1.168694488037818 0.242526743511501 1.0 0.577936069644428 3 P10321,P04439 2 +Mhc protein complex 0.8165600807808747 1.168694488037818 0.242526743511501 1.0 0.577936069644428 3 P10321,P04439 2 +Gamma secretase complex 0.8085464333782001 1.152579498684689 0.2490830220250273 1.0 0.5888611813573205 2 Q92542 1 +Late endosome membrane 0.3699199130942072 1.1500328604440102 0.2501303372155714 1.0 0.5897810056451368 38 P11279,O15118,Q14108,Q9UNK0,Q15043,Q9HC07,Q8IV08,Q14849,O95772,Q9BXS4,P13473,Q9P253,P51790 13 +Endoplasmic reticulum exit site 0.4017427985540837 1.135449069697528 0.2561872097913262 1.0 0.5977701561797613 20 Q9NR31,Q15436,Q969M3,Q96PC5,P04439,Q15437 6 +Side of membrane 0.3158231098259325 1.1074888225357722 0.2680826422455096 1.0 0.6190774418865376 67 Q9Y5X3,P41440,P07858,P10321,P51790,O75955,P20020,P01889,P27824,P17900,P51572,P08183,P11279,P42892,O96005,P49327,P10619,P04083,P62942,Q9NR28,P04439 21 +Caveola 0.482035394015137 1.0952146629362332 0.2734226033041627 1.0 0.6238879211378997 11 P09601,Q8WTV0,O75955 3 +Postsynaptic density membrane 0.6541543728882508 1.060908769888904 0.2887313633457338 1.0 0.6390005829252715 4 P57105 1 +Endolysosome lumen 0.7819650067294797 1.0413325785094134 0.2977212216594482 1.0 0.6390005829252715 2 P07858 1 +Mitotic spindle microtubule 0.5564577261028179 1.034831736831105 0.300747498681575 1.0 0.6390005829252715 6 O94927,Q96CS2,Q9H6D7 3 +Nuclear outer membrane 0.4943746334127158 1.0305420908933716 0.3027556042307995 1.0 0.6390005829252715 10 P50402,Q6NUM9,Q9UBM7,Q99720 4 +Blood microparticle 0.3997676099100474 1.0298947617121776 0.3030594100034367 1.0 0.6390005829252715 19 Q08380,P04062,P27105,P10909,P02786,P38435 6 +Nuclear pore outer ring 0.5347269049224429 1.010549142205778 0.3122322677665667 1.0 0.644510527821552 8 Q12769,Q8NFH4,Q9BW27,P57740,Q96EE3,Q8NFH3,P52948 7 +Lateral plasma membrane 0.4171339959677059 1.0091470699866798 0.3129041066990794 1.0 0.644510527821552 17 P05023,P53985,Q8TAA9,P33527 4 +Dendrite membrane 0.7728802153432043 1.0036452513548135 0.3155496349055333 1.0 0.6446579983270186 2 P20020 1 +Dendritic spine membrane 0.7728802153432043 1.0036452513548135 0.3155496349055333 1.0 0.6446579983270186 2 P20020 1 +Host cellular component 0.6377449955723965 0.9890919475085688 0.3226181570536659 1.0 0.6450088614973957 4 O00505 1 +Neuromuscular junction 0.4404169880944784 0.9886468538620756 0.3228359537414871 1.0 0.6450088614973957 14 O43760,P57105 2 +Endocytic vesicle 0.321120201274732 0.9857896024496844 0.324236369050364 1.0 0.6450088614973957 84 P51151,O43493,P13473,P10321,Q03518,P51790,P01889,Q5T9L3,P61421,Q06481,P11279,Q12846,O15400,O00461,Q9Y487,P61026,P08670,Q969Q5,Q9UNK0,Q93050,O75396,Q14108,Q16625,Q86Y82,P02786,P04439,Q8WTV0 27 +Zymogen granule 0.5839394186942483 0.981946898799966 0.3261260092769977 1.0 0.6464798767968806 5 Q15363 1 +Tertiary granule membrane 0.4602774665054214 0.9611927462370592 0.3364552629431054 1.0 0.6562857057696554 11 P27105,P10253,Q08722 3 +Cytoplasmic microtubule 0.4105469350095684 0.9602440661621036 0.3369323935870998 1.0 0.6562857057696554 17 Q9Y5M8,Q6NUQ4,Q86Y91 3 +Neurofilament 0.7613598115112743 0.9511669241250634 0.341519646003118 1.0 0.6594548789721593 3 P07197,Q16352 2 +Golgi associated vesicle 0.3600085524376094 0.9498743206106351 0.3421761164034007 1.0 0.6594548789721593 29 Q15363,Q8IUH4,P24390,Q8N511,O43493,P49755,Q9Y3B3 7 +Sarcoplasmic reticulum membrane 0.4584191880335067 0.9497497619490256 0.3422394182165782 1.0 0.6594548789721593 11 Q9BVC6,P62942,O75298,P16615 4 +Pole plasm 0.7584887412871364 0.9399903796423646 0.3472224953907128 1.0 0.6661913401928881 3 Q9HCE1 1 +Acrosomal membrane 0.7526917900403896 0.920680351298133 0.3572173375526275 1.0 0.6776772906207509 2 P35613 1 +Sarcolemma 0.3708109283149132 0.9187028639666872 0.3582510114120902 1.0 0.6776772906207509 23 P11279,P35613,Q92542,P04083,P05023,O75298,O75955 7 +Mitochondrial crista 0.7513458950201961 0.9151930549668702 0.3600902899677951 1.0 0.6792439996024093 2 O60313 1 +Cortical endoplasmic reticulum 0.7504174436232016 0.908669235280392 0.363524748181331 1.0 0.6809623734233139 3 P50402 1 +Dna replication preinitiation complex 0.49340193766289 0.9018490555087196 0.3671370567777421 1.0 0.6827347245513086 9 Q9Y248 1 +Platelet dense granule lumen 0.7459623149394428 0.8933045685743229 0.3716940920903426 1.0 0.6847307586622987 2 Q08380 1 +Platelet dense granule 0.7462133961628968 0.8924169143883991 0.3721695083354235 1.0 0.6847307586622987 3 Q08380,P13473 2 +Golgi apparatus 0.4337299065204966 0.8713910875351744 0.383540650446087 1.0 0.6923382014173363 298 O95197,Q9H7Z7,O14735,O43493,P50897,Q9UI14,Q9Y282,P51790,P80303,P24390,P01889,P04062,Q9NV96,Q9Y3A3,Q6NXT4,Q9HC07,Q15436,Q9NTJ5,O60499,P49755,Q15392,Q92544,Q9P2W9,Q5VW38,Q8N2A8,Q8TBQ9,O00461,Q9Y3E0,Q9BTV4,Q8N2H4,O15127,O15498,P05067,O95249,P22466,Q16739,Q93050,Q8NBN3,Q96A57,Q9UM00,Q8NF37,O75396,Q6NTF9,Q9H0U4,P62820,Q14108,P53365,Q6P1K2,Q7Z6M1,Q96L58,Q8IUH4,Q12907,Q9BSR8,P51151,O00400,Q02818,Q96RL7,Q7Z3D4,Q13636,P10909,O15260,Q8IZA0,Q8N4A0,P35613,Q9BUR5,Q8TAD4,Q9BXS4,O14773,Q8NCH0,Q9NQX7,O43505,Q9GZM5,O15118,Q9NX40,Q8TB61,Q6NUQ4,O15258,Q15363,O75503,O95070,Q9H4A6,Q10713,P05023,P10321,Q7LGA3,P16278,P18085,Q9NX62,L0R6Q1,Q8IV08,P40616,Q99805,Q13190,P06280,P49327,P61026,Q9Y3B3,Q92542,Q96S66,Q9NR31,P35670,Q9Y371,Q10472,P52292,Q5T9L3,Q9BRK5,O14828,Q969M3,P51572,Q12846,O43852,Q9UBF8,Q9UNK0,Q8IY95,Q96RQ1,Q86Y82,P04439,Q4J6C6 118 +Sarcoplasm 0.3891250352124307 0.8688499707714294 0.3849291967419237 1.0 0.6923382014173363 18 Q9BVC6,O43852,P16615,P62942,O75298,P52789 6 +Prefoldin complex 0.6097643097643106 0.8676556224166871 0.3855828867067261 1.0 0.6923382014173363 4 Q9UHV9,P61758,O15212 3 +Nls dependent protein nuclear import complex 0.5198863194195503 0.8527468493448398 0.3937997044004857 1.0 0.6923382014173363 6 O00505 1 +Ciliary transition zone 0.5123335696450304 0.8526321908449253 0.3938633052662474 1.0 0.6923382014173363 7 P41208,A6NIH7 2 +Coated vesicle membrane 0.3227956332861115 0.8464180478827821 0.3973195738133164 1.0 0.6926037706940301 52 Q15363,Q9NR31,P01889,P24390,O75396,Q14108,Q15436,Q8N511,Q13190,O43493,P49755,P10321,P04439,Q15437,Q9Y3B3 15 +Chromocenter 0.5165094339622601 0.8360427527173444 0.4031308520812633 1.0 0.6950459252179341 6 Q96GD4,P83916,P45973,Q9NQS7,Q06787 5 +Uniplex complex 0.7302770811985997 0.8312409922159713 0.4058375017631612 1.0 0.6966099647122461 3 Q8IYU8 1 +Platelet alpha granule membrane 0.7229888926287326 0.8035170529573092 0.42167594431664 1.0 0.7035784843718985 3 Q06481,Q96JJ7 2 +Presynapse 0.3071104826801771 0.7930153461828011 0.4277688818045004 1.0 0.7071603654923106 84 P41440,P50897,Q9UI14,Q9P253,P51790,O75955,P20020,Q7L0J3,P27824,O60499,P61421,P11279,Q12846,O15400,P07196,Q9BT78,O76024,Q9BVK6,P61026,O75150,Q07021,P05067,Q96A57,Q92542,Q86Y82,O43760,Q99623 27 +Flotillin complex 0.4962778356871268 0.736615693240603 0.4613560887680539 1.0 0.7333877141740299 6 P41440,O75955 2 +Endosome membrane 0.3352500926902739 0.7259553228522004 0.4678661597591107 1.0 0.7406503165091223 128 Q7Z6M1,Q9Y5X3,Q8N668,Q96RL7,Q14849,O95772,P13473,Q86YV9,P10321,Q9P253,Q9NPF0,P51790,P01889,Q9NV96,Q5T9L3,Q9HC07,Q8IV08,O14828,O60831,P61421,Q9BXS4,Q06481,P11279,P42892,O15400,Q99805,O00461,Q9Y487,P61026,O15127,Q96J02,Q9UNK0,Q93050,O15118,Q14108,Q9UH99,Q15043,Q15904,Q92542,O95219,Q86Y82,P02786,P04083,P04439 44 +Pam complex tim23 associated import motor 0.6965006729475159 0.69781946120433 0.4852901068088144 1.0 0.7496895443115478 2 Q96DA6 1 +Cul4 ring e3 ubiquitin ligase complex 0.486805458731133 0.690548993766231 0.4898490107082986 1.0 0.7528382737472309 6 P61962,Q9NXF7 2 +Microbody 0.3026153356363704 0.6707535252897485 0.5023775584823826 1.0 0.7642280006794819 55 P22307,P39210,Q6YN16,Q8NBU5,Q9BTZ2,O75381,O00116,Q96CN7,P50542,Q6IAN0,P48735,O95573,O15254,Q8N4Q0,Q9BY49,Q9Y5Y5,P08670,Q9Y3D6,P51648,Q9NR77,Q15067,O43808,Q5T8D3,O75192,P28288,P40855,O15228 27 +Cation transporting atpase complex 0.6855726584278687 0.664323031587414 0.5064835831732615 1.0 0.7651592575116604 3 P05023 1 +Atpase dependent transmembrane transport complex 0.6855726584278687 0.664323031587414 0.5064835831732615 1.0 0.7651592575116604 3 P05023 1 +Sodium potassium exchanging atpase complex 0.6855726584278687 0.664323031587414 0.5064835831732615 1.0 0.7651592575116604 3 P05023 1 +Vesicle membrane 0.3978664362671752 0.645451554760575 0.51863460307389 1.0 0.7707254301286933 248 Q9Y5X3,Q8N511,P30519,O95772,O43493,P13473,Q9P253,Q9NPF0,P51790,P20020,P24390,P01889,Q9NV96,Q9HC07,Q15436,P07602,O60831,O60499,P49755,P61421,Q06481,O15400,Q5T9A4,O00461,O15127,O15498,Q93050,Q8NF37,O75396,P62820,Q14108,Q9UH99,P02786,O43760,O00264,Q08722,Q7Z6M1,Q8IUH4,P51151,Q8N668,Q96RL7,Q14849,Q8NHP6,Q03518,Q15437,O15260,Q9NZJ7,P35613,O43924,Q8TAD4,Q9BXS4,Q9NQX7,O76024,Q07065,O15118,O15121,Q15043,Q8WTV0,Q15363,P10321,Q7L0J3,Q8IV08,P11279,P42892,Q99805,Q9Y487,P27105,Q13190,P61026,P10253,Q969Q5,Q9Y3B3,Q4KMQ2,Q15904,Q92542,Q9NR31,P42785,Q96JJ7,Q9H0U3,Q86YV9,Q9UIQ6,Q5T9L3,O14828,Q12846,Q96J02,Q9UNK0,O95219,Q86Y82,P04083,P04439 90 +Messenger ribonucleoprotein complex 0.5097011031009637 0.6398806349856448 0.522250204473405 1.0 0.7707254301286933 5 P51991 1 +Tertiary granule 0.3198206893940732 0.6374182548657329 0.5238524407905962 1.0 0.7707254301286933 39 Q93050,P11279,P42785,O15400,Q4KMQ2,P27105,Q9H8H3,P13473,P10253,Q13510,Q08722 11 +Tertiary granule lumen 0.3754387603470592 0.5966194270325623 0.5507614978263855 1.0 0.7959391968587765 15 Q9H8H3 1 +Mitochondrial pyruvate dehydrogenase complex 0.5444710923229055 0.5940388412614576 0.5524861346572161 1.0 0.7971458561237772 4 P09622 1 +Vacuole 0.3817620020332554 0.5801313189608158 0.561826064930079 1.0 0.8028396115110932 224 O75503,P42785,P17050,P09622,Q8NCC3,P54802,Q9UM22,Q9H7Z7,Q8N511,P41440,Q14849,O95772,Q9H0U3,P13473,Q9Y371,P50897,Q9BTY2,P07858,Q86YV9,Q9P253,P16278,P51790,O75955,O15260,O43681,Q9UIQ6,P04062,Q9NV96,Q9NZJ7,Q9HC07,Q15165,P07602,P17900,Q8IV08,Q9NRA0,Q9UHD9,Q8NHP8,P38435,P61421,Q9BXS4,P11279,P42892,O14773,Q12846,Q9Y487,Q9UHG3,Q9UMR5,P27105,P11117,P06865,Q9NQX7,P06280,Q07065,P51798,P10253,Q13510,Q5BJF2,Q969Q5,Q9Y6I9,Q9UNK0,Q93050,Q8IY95,Q96A57,P10619,O15118,Q8NF37,Q9NX40,Q14108,Q15043,Q92542,Q8WTV0 71 +Beta catenin destruction complex 0.5406884870017674 0.5788290179783765 0.5627045491394715 1.0 0.8028396115110932 4 Q9UJX6,Q9HB71 2 +T tubule 0.4610234230365468 0.5673621059341536 0.5704681897976727 1.0 0.8100467481120677 6 O75298 1 +Spindle midzone 0.3268957028844029 0.5211023996220412 0.6022954394079216 1.0 0.8422447195921956 20 Q13432,Q86Y91 2 +Postsynaptic specialization membrane 0.4379673196919847 0.5119853975942112 0.6086612293631912 1.0 0.8442112407266553 8 P52292,P57105 2 +Caspase complex 0.4470407860253053 0.5022963364484586 0.6154590858810525 1.0 0.8449070238916694 6 Q9H490,O43292 2 +Presynaptic active zone membrane 0.4779685530888237 0.5013314977247488 0.6161378413823966 1.0 0.8449070238916694 5 P27824,Q12846 2 +Extrinsic component of mitochondrial inner membrane 0.6291311864779395 0.4681635529194565 0.6396676340365974 1.0 0.8665435157653065 3 Q8NI60 1 +External encapsulating structure 0.3053386580072752 0.4553526855216751 0.6488555286340101 1.0 0.8742474491068768 30 Q08380,Q9NZJ7,Q53GQ0,P07602,Q13043,P04083,P07858,Q32P28 8 +Tight junction 0.3152021436976318 0.4455892968551984 0.6558939433622308 1.0 0.8797202395071482 23 Q86UE4 1 +Ccr4 not core complex 0.619320094244351 0.436309235305625 0.6626123821774923 1.0 0.8834831762366564 3 Q9NZN8,A5YKK6 2 +Cd40 receptor complex 0.6127185029873049 0.415319250107273 0.6779082109580696 1.0 0.8945592886869372 3 Q9NR28 1 +Collagen containing extracellular matrix 0.307601127030877 0.4115886612177402 0.6806409438841841 1.0 0.8955275854922597 26 Q08380,Q9NZJ7,P07602,Q13043,P04083,P07858,Q32P28 7 +Ino80 complex 0.4966329966329982 0.4094829944914513 0.6821852440063219 1.0 0.8962433704247278 4 Q9Y5K5,O96019,Q9Y230 3 +Intrinsic component of presynaptic membrane 0.4929051487691027 0.3959294909555289 0.6921570444426905 1.0 0.9040418539659631 4 P27824,Q92542 2 +Nuclear pore nuclear basket 0.412107558729009 0.3873066595344661 0.6985291959440378 1.0 0.9058835480244644 8 Q8NFH5 1 +Calcium channel complex 0.4076601776305693 0.366530240443848 0.7139694516214765 1.0 0.91388089807549 8 P62942 1 +Photoreceptor connecting cilium 0.4398787470528785 0.3461119699729869 0.7292585680116299 1.0 0.9216018010414956 5 O15078,P36405,P41208,Q15555 4 +Mitochondrion 0.4039998388553909 0.3311482440928594 0.7405325118768591 1.0 0.9257879819157572 599 O43169,Q99595,Q8NBX0,Q9Y2R0,O60830,Q96A26,Q8WY22,P14406,Q53H12,Q5JRX3,Q9UMS0,P09622,Q9H061,Q9H7Z7,Q9BRT2,Q69YU5,Q70HW3,Q9UBX3,P45880,Q9Y2W6,Q9UDW1,O75964,Q8N4H5,Q9NS69,Q16836,P21796,Q9Y5L4,P00846,Q96DA6,O43676,Q8NBU5,Q96NB2,P51970,Q9H2D1,Q6PI78,Q9H936,Q9NRA0,Q9H773,P11177,Q8N8Q8,P35232,O14949,Q15070,Q9NZ45,Q8IWA4,Q13505,Q9Y5J7,Q567V2,Q8N2A8,Q5T9A4,Q8N5N7,Q96I99,Q3SXM5,Q6DKK2,O43674,Q9H6K4,Q3ZCQ8,O15498,Q07021,Q9Y619,P03886,O75746,Q8N183,Q9BSK2,Q9BXK5,Q8IUX1,Q9NR77,P09601,Q5XKP0,Q07820,P02786,O75648,P12235,P53701,Q9H9B4,P82933,P28288,Q9UDX5,Q8TAE8,O00264,Q99623,Q8NI60,Q9NUQ2,P13073,Q96RL7,O14925,Q86Y39,Q9H3K2,P10909,O00584,O43464,Q14849,P36776,Q9Y277,Q8WWV3,Q5TC12,Q9NUJ1,Q13423,Q68CZ6,Q6PI48,Q9P0S9,P00367,O43772,Q6YN16,O00411,Q9NZJ7,P31930,P35613,P57105,Q9BUR5,O75438,Q9BW91,Q9Y6C9,Q96CU9,Q9BQT8,P24539,P23786,Q86UT6,Q9P0J0,P12236,Q96AQ8,P21912,O43819,P52789,Q8NBN7,O95202,Q9BWD1,O15121,Q99797,O95674,P13674,Q9NR28,Q9Y5J6,P22695,Q9HC21,P35610,Q9UJS0,Q9Y512,Q16740,Q9H4A6,Q9NUQ9,P00403,Q10713,O96000,Q9NQZ5,P05141,O95139,Q16539,Q9Y6M9,Q00325,Q12981,P22830,Q00059,Q9UG56,Q9H1A3,Q9Y320,Q96AY3,P27105,Q9NVI7,P28070,O75027,Q9BRJ2,Q9NWS8,O60313,Q92542,Q86VD7,Q6NUK1,O95168,Q9BWH2,Q9BW92,O75208,P00374,Q9NX63,O43292,P35670,Q9Y371,Q9Y5J9,Q96AG4,O96008,Q8WUK0,Q9H9P8,O43615,Q8IYU8,O95831,P16435,P30536,Q15165,Q9HCC0,Q8WWC4,Q5JTZ9,O00116,P51572,Q96ND0,Q6UXV4,P40939,P51649,Q9BY49,Q9UBF8,Q7Z7H8,Q15388,Q9BPW8,Q9UJZ1,P56385,O75880,P08574,Q9NUL7,Q6P4A7,P38646,P53007,Q16891 210 +Endosome 0.3541139829289809 0.3078544301751015 0.7581931022223669 1.0 0.934444318557415 210 Q7Z6M1,P51151,Q9Y5X3,Q8N668,Q96RL7,Q99538,Q9H4A6,P35670,P41440,Q14849,O95772,O43493,P13473,P07858,Q86YV9,P10321,Q9P253,Q9NPF0,P51790,O75955,P01889,Q9UIQ6,Q9NV96,Q9NZJ7,Q5T9L3,Q9HC07,P35613,P07602,Q9BRK5,Q8IV08,O14828,O60831,P35232,P61421,Q9BXS4,Q92544,Q06481,P11279,P42892,O15400,O14773,Q5VW38,Q99805,Q12846,O00461,Q9Y487,Q9GZP9,P61026,O15127,Q9UBF8,O15498,Q13510,P05067,Q96J02,Q969Q5,Q9BUN8,Q93050,Q9UNK0,Q8IY95,Q96A57,O15118,P62820,Q14108,Q9NX40,Q9UH99,Q15043,Q15904,Q92542,O95219,Q86Y82,P02786,P04083,P04439 73 +Mhc class i peptide loading complex 0.4661916358509629 0.3031649773397232 0.7617641378177455 1.0 0.9362697770709192 4 Q03518 1 +Plasma membrane raft 0.3104213970600312 0.2863935942302986 0.7745766803927998 1.0 0.9401488762003776 18 P41440,P09601,Q8WTV0,O75955 4 +Nucleocytoplasmic transport complex 0.3888525909386877 0.2813199770629587 0.7784649892899156 1.0 0.9401488762003776 8 O00505 1 +Apical junction complex 0.2920706030561032 0.2801523188102474 0.7793606464727896 1.0 0.9401488762003776 26 Q86UE4 1 +Extrinsic component of organelle membrane 0.3445497719939152 0.2798272274054662 0.7796100614027686 1.0 0.9401488762003776 11 P04083,P62942,Q9Y5X3,Q15006 4 +U12 type spliceosomal complex 0.3250004681102727 0.2421477104388963 0.8086657104154917 1.0 0.953376803913504 14 Q9UK45 1 +Extrinsic component of endosome membrane 0.5519894865761602 0.2418162490122702 0.8089225476220168 1.0 0.953376803913504 3 P04083 1 +Copii vesicle coat 0.3360325507117127 0.235473768871011 0.8138410359258246 1.0 0.953376803913504 11 Q9NR31,Q15437,Q9Y3B3 3 +High density lipoprotein particle 0.5488475065044447 0.233921915399031 0.8150455991346257 1.0 0.953376803913504 3 Q9BUR5 1 +Dendrite cytoplasm 0.3435400058023656 0.2017052904202058 0.8401471264539506 1.0 0.9754529763889244 10 Q14254,P27824,P23246,Q8N2K0 4 +Myelin sheath 0.343156320710437 0.1999164470937255 0.8415459271748198 1.0 0.9754529763889244 10 Q9NR77 1 +Proteasome core complex 0.3159693868686009 0.1909955257920119 0.8485290985335205 1.0 0.982276579180923 14 P49721,P28070 2 +Smooth endoplasmic reticulum 0.3363505120904498 0.1686841214894053 0.8660451090108814 1.0 0.9944840023950432 10 P27824,O00264 2 +Hops complex 0.418855218855217 0.16126390164048 0.8718855534081804 1.0 0.9977818076041663 4 Q96AX1,Q9P253,Q9H269 3 +Epsilon dna polymerase complex 0.4154882154882126 0.1524305861111132 0.8788473347117354 1.0 1.0 4 Q9NRF9,Q9NR33,Q9NRG0 3 +Escrt i complex 0.5107671601615076 0.1467365786564018 0.883339945502734 1.0 1.0 2 Q99816 1 +Anchored component of synaptic vesicle membrane 0.5008414675193374 0.1284501626722459 0.8977927358365614 1.0 1.0 3 P61020,P51149 2 +Lateral element 0.4949528936743042 0.1198089911451379 0.904634459347391 1.0 1.0 2 Q9NQS7 1 +Nuclear inclusion body 0.3517520215633418 0.1176306987567794 0.9063602797159432 1.0 1.0 6 P49792,Q86U42,P12270,P52948,Q9UBU9 5 +Mcrd mediated mrna stability complex 0.3711433528880956 0.1136898974286977 0.9094836212775976 1.0 1.0 5 O60506 1 +Early phagosome 0.3945935195755838 0.1017145038833832 0.9189832894228452 1.0 1.0 4 Q06481 1 +Brisc complex 0.4764468371467132 0.0927474650127215 0.9261041878664154 1.0 1.0 2 P34897 1 +Hulc complex 0.4754374158815702 0.0914061603502678 0.9271698669917494 1.0 1.0 2 O75150 1 +Cuticular plate 0.4744279946164299 0.0900785384661563 0.9282248036992348 1.0 1.0 2 Q01082 1 +Glial cell projection 0.3868686868686831 0.0847996629348435 0.932420661515615 1.0 1.0 4 P05067,P05556,Q06787 3 +Postsynaptic specialization intracellular component 0.379461279461277 0.0695282456899034 0.944569150240728 1.0 1.0 4 Q9UQB8,P50570,O60716 3 +Postsynaptic density intracellular component 0.379461279461277 0.0695282456899034 0.944569150240728 1.0 1.0 4 Q9UQB8,P50570,O60716 3 +Clathrin coated endocytic vesicle membrane 0.2959371872799472 0.0687675661392251 0.94517463542028 1.0 1.0 13 Q14108,O43493,P02786 3 +Proton transporting v type atpase v1 domain 0.3348166139583767 0.0653253508701849 0.9479149583739448 1.0 1.0 7 P36543,Q15904,P21283 3 +Presynaptic cytoskeleton 0.4454912516823738 0.0576175900176263 0.9540532381409812 1.0 1.0 2 P07196 1 +Mitochondrial large ribosomal subunit 0.2614898368813056 0.0514017514521722 0.9590053891630156 1.0 1.0 28 Q9H2W6,Q9BRJ2,Q567V2,Q8N5N7,Q9NVS2,Q7Z7H8 6 +Neuron projection membrane 0.3277700952180538 0.043559863418505 0.9652552456617812 1.0 1.0 7 Q12846,P20020 2 +Sperm connecting piece 0.4138627187079383 0.0332844995371592 0.973447714489002 1.0 1.0 2 P10644 1 +Nucleotide activated protein kinase complex 0.3545454545454518 0.0249978083467095 0.9800567117495158 1.0 1.0 4 P54619,P54646,P10644 3 +Ficolin 1 rich granule membrane 0.2754729840493755 0.0174578139258307 0.986071387322912 1.0 1.0 16 Q93050,P11279,P42785,Q5T9A4,P13473,P10253 6 +Chromosome passenger complex 0.3471380471380451 0.0137684389144245 0.989014722244606 1.0 1.0 4 Q53HL2,Q96GD4,Q9NQS7 3 +Wash complex 0.4140020195220464 0.0123865780738555 0.9901171933097556 1.0 1.0 3 Q12768,P52907 2 +Keratin filament 0.3539703903095504 0.0105308317862815 0.9915977672046552 1.0 1.0 2 P48729 1 +Dendritic shaft 0.3410774410774412 0.0052483383998393 0.9958124510452866 1.0 1.0 4 P46459,Q9UQB8,P05067 3 +Postsynaptic cytoskeleton 0.2886944818304089 0.004056145283501 0.9967636731761014 1.0 1.0 2 P07196 1 diff --git a/msigdb_gocc/selections.json b/msigdb_gocc/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..5b6ed13054f804909730d37cb2e0f48451d34719 --- /dev/null +++ b/msigdb_gocc/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["90s preribosome", "9plus0 non motile cilium", "9plus2 motile cilium", "A band", "Acrosomal membrane", "Acrosomal vesicle", "Actin based cell projection", "Actin cytoskeleton", "Actin filament", "Actin filament bundle", "Actomyosin", "Adherens junction", "Aggresome", "Alpha dna polymerase primase complex", "Alveolar lamellar body", "Aminoacyl trna synthetase multienzyme complex", "Ampa glutamate receptor complex", "Amphisome", "Amphisome membrane", "Anaphase promoting complex", "Anchored component of membrane", "Anchored component of plasma membrane", "Anchored component of synaptic membrane", "Anchored component of synaptic vesicle membrane", "Anchoring junction", "Annulate lamellae", "Ap 1 adaptor complex", "Ap 3 adaptor complex", "Ap type membrane coat adaptor complex", "Apical dendrite", "Apical junction complex", "Apical part of cell", "Apical plasma membrane", "Apicolateral plasma membrane", "Arp2 3 protein complex", "Aryl hydrocarbon receptor complex", "Aster", "Astrocyte end foot", "Astrocyte projection", "Atac complex", "Atpase complex", "Atpase dependent transmembrane transport complex", "Autolysosome", "Autophagosome", "Autophagosome membrane", "Axolemma", "Axon", "Axon cytoplasm", "Axon hillock", "Axonal growth cone", "Azurophil granule", "Azurophil granule lumen", "Azurophil granule membrane", "B wich complex", "Barr body", "Basal cortex", "Basal dendrite", "Basal part of cell", "Basement membrane", "Basolateral plasma membrane", "Bcl 2 family protein complex", "Beta catenin destruction complex", "Beta catenin tcf complex", "Bleb", "Bloc complex", "Blood microparticle", "Box c d rnp complex", "Box h aca rnp complex", "Box h aca snornp complex", "Box h aca telomerase rnp complex", "Brca1 a complex", "Brca1 c complex", "Brisc complex", "Brush border", "Brush border membrane", "Cajal body", "Calcineurin complex", "Calcium and calmodulin dependent protein kinase complex", "Calcium channel complex", "Calyx of held", "Camp dependent protein kinase complex", "Carboxy terminal domain protein kinase complex", "Caspase complex", "Catalytic complex", "Catalytic step 1 spliceosome", "Catalytic step 2 spliceosome", "Catenin complex", "Cation channel complex", "Cation transporting atpase complex", "Catsper complex", "Caveola", "Ccaat binding factor complex", "Ccr4 not complex", "Ccr4 not core complex", "Cd40 receptor complex", "Cd95 death inducing signaling complex", "Cdc73 paf1 complex", "Cell body", "Cell body membrane", "Cell cell contact zone", "Cell cell junction", "Cell cortex", "Cell cortex region", "Cell division site", "Cell leading edge", "Cell pole", "Cell projection membrane", "Cell substrate junction", "Cell surface", "Cell tip", "Cell trailing edge", "Central element", "Centriolar satellite", "Centriolar subdistal appendage", "Centriole", "Centrosome", "Chaperone complex", "Chaperonin containing t complex", "Checkpoint clamp complex", "Chitosome", "Chloride channel complex", "Cholinergic synapse", "Chromaffin granule", "Chromaffin granule membrane", "Chromatin", "Chromatin silencing complex", "Chromatoid body", "Chromocenter", "Chromosomal region", "Chromosome", "Chromosome centromeric core domain", "Chromosome centromeric region", "Chromosome passenger complex", "Chromosome telomeric region", "Chromosome telomeric repeat region", "Cia complex", "Ciliary basal body", "Ciliary base", "Ciliary membrane", "Ciliary plasm", "Ciliary rootlet", "Ciliary tip", "Ciliary transition zone", "Cilium", "Cis golgi network", "Clathrin adaptor complex", "Clathrin coat", "Clathrin coat of coated pit", "Clathrin coat of endocytic vesicle", "Clathrin coated endocytic vesicle", "Clathrin coated endocytic vesicle membrane", "Clathrin coated pit", "Clathrin coated vesicle", "Clathrin coated vesicle membrane", "Clathrin complex", "Clathrin sculpted gamma aminobutyric acid transport vesicle", "Clathrin sculpted vesicle", "Clathrin vesicle coat", "Cleavage furrow", "Cluster of actin based cell projections", "Coated vesicle", "Coated vesicle membrane", "Cohesin complex", "Collagen containing extracellular matrix", "Collagen trimer", "Commitment complex", "Compact myelin", "Condensed chromosome", "Condensed chromosome centromeric region", "Condensed nuclear chromosome", "Condensin complex", "Contractile fiber", "Contractile ring", "Cop9 signalosome", "Copi coated vesicle", "Copi coated vesicle membrane", "Copi vesicle coat", "Copii coated er to golgi transport vesicle", "Copii vesicle coat", "Core mediator complex", "Cornified envelope", "Cortical actin cytoskeleton", "Cortical cytoskeleton", "Cortical endoplasmic reticulum", "Cortical granule", "Costamere", "Crd mediated mrna stability complex", "Ctf18 rfc like complex", "Cul2 ring ubiquitin ligase complex", "Cul3 ring ubiquitin ligase complex", "Cul4 ring e3 ubiquitin ligase complex", "Cul4a ring e3 ubiquitin ligase complex", "Cul4b ring e3 ubiquitin ligase complex", "Cul5 ring ubiquitin ligase complex", "Cullin ring ubiquitin ligase complex", "Cuticular plate", "Cyclin a2 cdk2 complex", "Cyclin dependent protein kinase holoenzyme complex", "Cytochrome complex", "Cytolytic granule", "Cytoplasmic dynein complex", "Cytoplasmic exosome rnase complex", "Cytoplasmic microtubule", "Cytoplasmic region", "Cytoplasmic side of endoplasmic reticulum membrane", "Cytoplasmic side of endosome membrane", "Cytoplasmic side of lysosomal membrane", "Cytoplasmic side of membrane", "Cytoplasmic stress granule", "Cytoplasmic ubiquitin ligase complex", "Cytoskeleton of presynaptic active zone", "Cytosolic large ribosomal subunit", "Cytosolic region", "Cytosolic ribosome", "Cytosolic small ribosomal subunit", "Death inducing signaling complex", "Dendrite cytoplasm", "Dendrite membrane", "Dendrite terminus", "Dendritic growth cone", "Dendritic shaft", "Dendritic spine membrane", "Dendritic tree", "Dense body", "Dense core granule", "Dentate gyrus mossy fiber", "Derlin 1 retrotranslocation complex", "Desmosome", "Dihydrolipoyl dehydrogenase complex", "Distal axon", "Dna packaging complex", "Dna polymerase complex", "Dna repair complex", "Dna replication factor c complex", "Dna replication preinitiation complex", "Dopaminergic synapse", "Dynactin complex", "Dynein axonemal particle", "Dynein complex", "Dystroglycan complex", "Dystrophin associated glycoprotein complex", "Early endosome", "Early endosome lumen", "Early endosome membrane", "Early phagosome", "Ekc keops complex", "Elongator holoenzyme complex", "Elongin complex", "Emc complex", "Endocytic vesicle", "Endocytic vesicle lumen", "Endocytic vesicle membrane", "Endolysosome", "Endolysosome lumen", "Endolysosome membrane", "Endopeptidase complex", "Endoplasmic reticulum", "Endoplasmic reticulum chaperone complex", "Endoplasmic reticulum exit site", "Endoplasmic reticulum golgi intermediate compartment", "Endoplasmic reticulum golgi intermediate compartment membrane", "Endoplasmic reticulum lumen", "Endoplasmic reticulum palmitoyltransferase complex", "Endoplasmic reticulum plasma membrane contact site", "Endoplasmic reticulum protein containing complex", "Endoplasmic reticulum quality control compartment", "Endoplasmic reticulum tubular network", "Endoplasmic reticulum tubular network membrane", "Endoribonuclease complex", "Endosome", "Endosome lumen", "Endosome membrane", "Envelope", "Enzyme activator complex", "Epsilon dna polymerase complex", "Equatorial microtubule organizing center", "Er membrane insertion complex", "Er to golgi transport vesicle membrane", "Er ubiquitin ligase complex", "Esc e z complex", "Escrt complex", "Escrt i complex", "Escrt iii complex", "Euchromatin", "Eukaryotic translation initiation factor 2 complex", "Eukaryotic translation initiation factor 2b complex", "Eukaryotic translation initiation factor 3 complex", "Eukaryotic translation initiation factor 3 complex eif3m", "Eukaryotic translation initiation factor 4f complex", "Excitatory synapse", "Exocyst", "Exocytic vesicle", "Exon exon junction complex", "Exoribonuclease complex", "External encapsulating structure", "External side of apical plasma membrane", "External side of plasma membrane", "Extrinsic component of cytoplasmic side of plasma membrane", "Extrinsic component of endoplasmic reticulum membrane", "Extrinsic component of endosome membrane", "Extrinsic component of external side of plasma membrane", "Extrinsic component of membrane", "Extrinsic component of mitochondrial inner membrane", "Extrinsic component of organelle membrane", "Extrinsic component of plasma membrane", "Extrinsic component of postsynaptic membrane", "Extrinsic component of postsynaptic specialization membrane", "Extrinsic component of synaptic membrane", "F actin capping protein complex", "Fascia adherens", "Female germ cell nucleus", "Female pronucleus", "Fibrillar center", "Ficolin 1 rich granule", "Ficolin 1 rich granule lumen", "Ficolin 1 rich granule membrane", "Filamentous actin", "Filopodium", "Filopodium membrane", "Filopodium tip", "Filtration diaphragm", "Flemming body", "Flotillin complex", "Gaba ergic synapse", "Gamma secretase complex", "Gamma tubulin complex", "Gamma tubulin large complex", "Gap junction", "Gator2 complex", "Gemini of coiled bodies", "Germ cell nucleus", "Gid complex", "Glial cell projection", "Glutamatergic synapse", "Glycinergic synapse", "Glycogen granule", "Glycoprotein complex", "Golgi apparatus", "Golgi apparatus subcompartment", "Golgi associated vesicle", "Golgi associated vesicle membrane", "Golgi cis cisterna", "Golgi cisterna", "Golgi cisterna membrane", "Golgi lumen", "Golgi medial cisterna", "Golgi membrane", "Golgi stack", "Golgi trans cisterna", "Golgi transport complex", "Gpi anchor transamidase complex", "Granular component", "Growth cone membrane", "Gtpase complex", "Guanyl nucleotide exchange factor complex", "H3 histone acetyltransferase complex", "H4 h2a histone acetyltransferase complex", "H4 histone acetyltransferase complex", "Haus complex", "Hemidesmosome", "Hemoglobin complex", "Heterochromatin", "Hfe transferrin receptor complex", "High density lipoprotein particle", "Hippocampal mossy fiber", "Hippocampal mossy fiber to ca3 synapse", "Histone deacetylase complex", "Histone methyltransferase complex", "Histone pre mrna 3 end processing complex", "Hops complex", "Host cellular component", "Hrd1p ubiquitin ligase erad l complex", "Hulc complex", "I band", "Ikappab kinase complex", "Immunological synapse", "Inclusion body", "Inflammasome complex", "Inhibitory synapse", "Inner mitochondrial membrane protein complex", "Ino80 complex", "Ino80 type complex", "Insulin responsive compartment", "Integral component of cytoplasmic side of endoplasmic reticulum membrane", "Integral component of lysosomal membrane", "Integral component of presynaptic active zone membrane", "Integral component of synaptic vesicle membrane", "Integrator complex", "Integrin complex", "Intercalated disc", "Intercellular bridge", "Intercellular canaliculus", "Intermediate filament", "Intermediate filament cytoskeleton", "Intracellular protein containing complex", "Intraciliary transport particle", "Intraciliary transport particle b", "Intrinsic component of endoplasmic reticulum membrane", "Intrinsic component of golgi membrane", "Intrinsic component of mitochondrial inner membrane", "Intrinsic component of mitochondrial membrane", "Intrinsic component of mitochondrial outer membrane", "Intrinsic component of nuclear inner membrane", "Intrinsic component of organelle membrane", "Intrinsic component of peroxisomal membrane", "Intrinsic component of plasma membrane", "Intrinsic component of postsynaptic density membrane", "Intrinsic component of postsynaptic membrane", "Intrinsic component of postsynaptic specialization membrane", "Intrinsic component of presynaptic active zone membrane", "Intrinsic component of presynaptic membrane", "Intrinsic component of synaptic membrane", "Intrinsic component of synaptic vesicle membrane", "Intrinsic component of vacuolar membrane", "Ion channel complex", "Iron sulfur cluster assembly complex", "Iswi type complex", "Juxtaparanode region of axon", "Keratin filament", "Kinesin complex", "Kinetochore microtubule", "Lamellar body", "Lamellipodium", "Lamellipodium membrane", "Lamin filament", "Large ribosomal subunit", "Late endosome", "Late endosome membrane", "Lateral element", "Lateral part of cell", "Lateral plasma membrane", "Leading edge membrane", "Lewy body", "Lipid droplet", "Lipopolysaccharide receptor complex", "Low density lipoprotein particle", "Lsm1 7 pat1 complex", "Lsm2 8 complex", "Lumenal side of endoplasmic reticulum membrane", "Lumenal side of membrane", "Lysosomal lumen", "M band", "Magnesium dependent protein serine threonine phosphatase complex", "Main axon", "Male germ cell nucleus", "Male pronucleus", "Manchette", "Mcm complex", "Mcrd mediated mrna stability complex", "Mediator complex", "Meiotic cohesin complex", "Meiotic spindle", "Membrane coat", "Membrane microdomain", "Membrane protein complex", "Messenger ribonucleoprotein complex", "Methylosome", "Methyltransferase complex", "Mhc class i peptide loading complex", "Mhc class i protein complex", "Mhc protein complex", "Mib complex", "Micos complex", "Microbody", "Microbody lumen", "Microbody membrane", "Microtubule", "Microtubule associated complex", "Microtubule bundle", "Microtubule cytoskeleton", "Microtubule end", "Microtubule minus end", "Microtubule organizing center", "Microtubule organizing center attachment site", "Microtubule plus end", "Microvillus", "Microvillus membrane", "Midbody", "Mismatch repair complex", "Mitochondria associated endoplasmic reticulum membrane", "Mitochondrial alpha ketoglutarate dehydrogenase complex", "Mitochondrial crista", "Mitochondrial envelope", "Mitochondrial intermembrane space protein transporter complex", "Mitochondrial large ribosomal subunit", "Mitochondrial matrix", "Mitochondrial permeability transition pore complex", "Mitochondrial protein containing complex", "Mitochondrial proton transporting atp synthase complex coupling factor f o", "Mitochondrial pyruvate dehydrogenase complex", "Mitochondrial small ribosomal subunit", "Mitochondrial tricarboxylic acid cycle enzyme complex", "Mitochondrion", "Mitotic cohesin complex", "Mitotic spindle", "Mitotic spindle astral microtubule", "Mitotic spindle microtubule", "Mitotic spindle midzone", "Mitotic spindle pole", "Mks complex", "Mll1 2 complex", "Mll3 4 complex", "Mmxd complex", "Mon1 ccz1 complex", "Motile cilium", "Mpp7 dlg1 lin7 complex", "Mrna cleavage and polyadenylation specificity factor complex", "Mrna cleavage factor complex", "Mrna editing complex", "Multimeric ribonuclease p complex", "Multivesicular body", "Multivesicular body membrane", "Myelin sheath", "Myelin sheath abaxonal region", "Myelin sheath adaxonal region", "Myofilament", "Myosin complex", "Myosin filament", "Myosin ii complex", "N terminal protein acetyltransferase complex", "Nadh dehydrogenase complex", "Nascent polypeptide associated complex", "Nata complex", "Nbaf complex", "Neurofibrillary tangle", "Neurofilament", "Neuromuscular junction", "Neuron projection", "Neuron projection cytoplasm", "Neuron projection membrane", "Neuron projection terminus", "Neuron spine", "Neuron to neuron synapse", "Neuronal dense core vesicle", "Neuronal ribonucleoprotein granule", "Neurotransmitter receptor complex", "Nlrp3 inflammasome complex", "Nls dependent protein nuclear import complex", "Node of ranvier", "Non motile cilium", "Nonhomologous end joining complex", "Npbaf complex", "Nsl complex", "Nuclear body", "Nuclear chromosome", "Nuclear cyclin dependent protein kinase holoenzyme complex", "Nuclear envelope", "Nuclear envelope lumen", "Nuclear exosome rnase complex", "Nuclear inclusion body", "Nuclear inner membrane", "Nuclear lamina", "Nuclear membrane", "Nuclear outer membrane", "Nuclear outer membrane endoplasmic reticulum membrane network", "Nuclear periphery", "Nuclear pore", "Nuclear pore central transport channel", "Nuclear pore nuclear basket", "Nuclear pore outer ring", "Nuclear protein containing complex", "Nuclear replication fork", "Nuclear rna export factor complex", "Nuclear speck", "Nuclear stress granule", "Nuclear ubiquitin ligase complex", "Nucleocytoplasmic transport complex", "Nucleoid", "Nucleolar ribonuclease p complex", "Nucleolus", "Nucleotide activated protein kinase complex", "Nucleotide excision repair complex", "Nurd complex", "Nurf complex", "Oligosaccharyltransferase complex", "Organellar ribosome", "Organelle envelope lumen", "Organelle inner membrane", "Organelle membrane contact site", "Organelle subcompartment", "Origin recognition complex", "Outer dense fiber", "Outer kinetochore", "Outer membrane", "Outer mitochondrial membrane protein complex", "Oxidoreductase complex", "Oxoglutarate dehydrogenase complex", "P body", "Palmitoyltransferase complex", "Pam complex tim23 associated import motor", "Parallel fiber to purkinje cell synapse", "Paranodal junction", "Paranode region of axon", "Paraspeckles", "Pcg protein complex", "Peptidase complex", "Peptidase inhibitor complex", "Pericentric heterochromatin", "Pericentriolar material", "Perikaryon", "Perinuclear endoplasmic reticulum", "Perinuclear region of cytoplasm", "Perinucleolar compartment", "Phagocytic cup", "Phagocytic vesicle", "Phagocytic vesicle lumen", "Phagocytic vesicle membrane", "Phagolysosome", "Phagophore assembly site", "Phagophore assembly site membrane", "Phosphatase complex", "Phosphatidylinositol 3 kinase complex", "Phosphatidylinositol 3 kinase complex class iii", "Phospholipid translocating atpase complex", "Phosphorylase kinase complex", "Photoreceptor connecting cilium", "Photoreceptor inner segment", "Photoreceptor outer segment", "Photoreceptor ribbon synapse", "Pi body", "Picln sm protein complex", "Pigment granule", "Pinosome", "Pip body", "Plasma membrane protein complex", "Plasma membrane raft", "Plasma membrane region", "Plasma membrane signaling receptor complex", "Platelet alpha granule", "Platelet alpha granule lumen", "Platelet alpha granule membrane", "Platelet dense granule", "Platelet dense granule lumen", "Platelet dense granule membrane", "Platelet dense tubular network", "Platelet dense tubular network membrane", "Pml body", "Podosome", "Polar microtubule", "Pole plasm", "Polymeric cytoskeletal fiber", "Polysomal ribosome", "Polysome", "Pore complex", "Post mrna release spliceosomal complex", "Postsynapse", "Postsynaptic cytoskeleton", "Postsynaptic cytosol", "Postsynaptic density intracellular component", "Postsynaptic density membrane", "Postsynaptic endocytic zone", "Postsynaptic endosome", "Postsynaptic membrane", "Postsynaptic recycling endosome", "Postsynaptic specialization intracellular component", "Postsynaptic specialization membrane", "Potassium channel complex", "Prc1 complex", "Pre snornp complex", "Precatalytic spliceosome", "Prefoldin complex", "Preribosome", "Preribosome large subunit precursor", "Preribosome small subunit precursor", "Prespliceosome", "Presynapse", "Presynaptic active zone", "Presynaptic active zone cytoplasmic component", "Presynaptic active zone membrane", "Presynaptic cytoskeleton", "Presynaptic cytosol", "Presynaptic endocytic zone", "Presynaptic membrane", "Pronucleus", "Protease inhibitor complex", "Proteasome accessory complex", "Proteasome complex", "Proteasome core complex", "Proteasome core complex alpha subunit complex", "Proteasome core complex beta subunit complex", "Proteasome regulatory particle", "Proteasome regulatory particle base subcomplex", "Proteasome regulatory particle lid subcomplex", "Protein acetyltransferase complex", "Protein complex involved in cell adhesion", "Protein dna complex", "Protein kinase complex", "Protein lipid complex", "Protein phosphatase 4 complex", "Protein phosphatase type 1 complex", "Protein phosphatase type 2a complex", "Proton transporting atp synthase complex", "Proton transporting atp synthase complex catalytic core f 1", "Proton transporting atp synthase complex coupling factor f o", "Proton transporting two sector atpase complex", "Proton transporting two sector atpase complex catalytic domain", "Proton transporting two sector atpase complex proton transporting domain", "Proton transporting v type atpase complex", "Proton transporting v type atpase v0 domain", "Proton transporting v type atpase v1 domain", "Proximal dendrite", "Prp19 complex", "Pseudopodium", "Ptw pp1 phosphatase complex", "Pwp2p containing subcomplex of 90s preribosome", "R2tp complex", "Ragulator complex", "Rdna heterochromatin", "Receptor complex", "Recycling endosome", "Recycling endosome membrane", "Replication fork", "Replisome", "Respirasome", "Respiratory chain complex iii", "Respiratory chain complex iv", "Retromer complex", "Ribbon synapse", "Ribonuclease mrp complex", "Ribonuclease p complex", "Ribonucleoprotein complex", "Ribonucleoprotein granule", "Ribose phosphate diphosphokinase complex", "Ribosomal subunit", "Ribosome", "Risc loading complex", "Rna cap binding complex", "Rna polymerase complex", "Rna polymerase i complex", "Rna polymerase ii core complex", "Rna polymerase ii holoenzyme", "Rna polymerase ii transcription regulator complex", "Rna polymerase ii transcription repressor complex", "Rna polymerase iii complex", "Rna polymerase iii transcription regulator complex", "Rnai effector complex", "Rough endoplasmic reticulum", "Rough endoplasmic reticulum membrane", "Rpap3 r2tp prefoldin like complex", "Ruffle", "Ruffle membrane", "Saga complex", "Saga type complex", "Sarcolemma", "Sarcoplasm", "Sarcoplasmic reticulum lumen", "Sarcoplasmic reticulum membrane", "Scar complex", "Scf ubiquitin ligase complex", "Schaffer collateral ca1 synapse", "Sec61 translocon complex", "Secondary lysosome", "Secretory granule", "Secretory granule membrane", "Secretory vesicle", "Seh1 associated complex", "Septin cytoskeleton", "Serine protease inhibitor complex", "Serine type endopeptidase complex", "Serine type peptidase complex", "Set1c compass complex", "Sex chromatin", "Sex chromosome", "Shelterin complex", "Side of membrane", "Signal peptidase complex", "Signal recognition particle", "Sin3 complex", "Sin3 type complex", "Site of dna damage", "Site of double strand break", "Site of polarized growth", "Sm like protein family complex", "Small ribosomal subunit", "Small subunit processome", "Smc5 smc6 complex", "Smn complex", "Smn sm protein complex", "Smooth endoplasmic reticulum", "Smooth endoplasmic reticulum membrane", "Snare complex", "Sno s rna containing ribonucleoprotein complex", "Sodium potassium exchanging atpase complex", "Somatodendritic compartment", "Sorting endosome", "Specific granule", "Specific granule lumen", "Specific granule membrane", "Spectrin", "Spectrin associated cytoskeleton", "Sperm annulus", "Sperm connecting piece", "Sperm fibrous sheath", "Sperm head", "Sperm head plasma membrane", "Sperm midpiece", "Sperm plasma membrane", "Sperm principal piece", "Spermatoproteasome complex", "Spherical high density lipoprotein particle", "Spindle", "Spindle microtubule", "Spindle midzone", "Spindle pole", "Spindle pole centrosome", "Spliceosomal complex", "Spliceosomal snrnp complex", "Spliceosomal tri snrnp complex", "Stereocilium bundle", "Stereocilium membrane", "Stereocilium tip", "Striated muscle thin filament", "Sumo ligase complex", "Supramolecular complex", "Supramolecular polymer", "Swi snf complex", "Swr1 complex", "Synapse", "Synaptic membrane", "Synaptic vesicle membrane", "Synaptonemal structure", "T tubule", "Telomerase holoenzyme complex", "Terminal bouton", "Tertiary granule", "Tertiary granule lumen", "Tertiary granule membrane", "Tetraspanin enriched microdomain", "Tho complex", "Tight junction", "Tim22 mitochondrial import inner membrane insertion complex", "Tim23 mitochondrial import inner membrane translocase complex", "Tor complex", "Torc1 complex", "Trans golgi network", "Trans golgi network membrane", "Trans golgi network transport vesicle", "Trans golgi network transport vesicle membrane", "Transcription elongation factor complex", "Transcription export complex", "Transcription export complex 2", "Transcription factor tfiid complex", "Transcription factor tfiih holo complex", "Transcription factor tfiiic complex", "Transcription factor tftc complex", "Transcription preinitiation complex", "Transcription regulator complex", "Transcription repressor complex", "Transferase complex", "Transferase complex transferring phosphorus containing groups", "Translation preinitiation complex", "Translocon complex", "Transport vesicle", "Transport vesicle membrane", "Transporter complex", "Trapp complex", "Tricarboxylic acid cycle enzyme complex", "Triglyceride rich plasma lipoprotein particle", "Trna methyltransferase complex", "Trna splicing ligase complex", "Tubular endosome", "U1 snrnp", "U12 type spliceosomal complex", "U2 snrnp", "U2 type catalytic step 2 spliceosome", "U2 type spliceosomal complex", "U2af complex", "U4 snrnp", "U5 snrnp", "U6 snrnp", "U7 snrnp", "Ubiquinone biosynthesis complex", "Ubiquitin conjugating enzyme complex", "Ubiquitin ligase complex", "Unconventional myosin complex", "Uniplex complex", "Vacuolar lumen", "Vacuolar membrane", "Vacuolar proton transporting v type atpase v0 domain", "Vacuole", "Varicosity", "Vcp npl4 ufd1 aaa atpase complex", "Vesicle coat", "Vesicle lumen", "Vesicle membrane", "Vesicle tethering complex", "Voltage gated calcium channel complex", "Wash complex", "Weibel palade body", "Wnt signalosome", "X chromosome", "Xy body", "Zona pellucida receptor complex", "Zonula adherens", "Zymogen granule", "Zymogen granule membrane"], "available_proteins": ["AAAS", "AAMP", "AAR2", "AARS", "AARS2", "AASS", "AATF", "ABCB1", "ABCB7", "ABCC1", "ABCD3", "ABCE1", "ABCF1", "ABHD10", "ABHD12", "ABHD14B", "ABHD6", "ABI1", "ACAA2", "ACACA", "ACACB", "ACAD11", "ACAD9", "ACADM", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACBD5", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT9", "ACOX1", "ACOX3", "ACP1", "ACP2", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN4", "ACTR10", "ACTR1A", "ACTR1B", "ACTR2", "ACTR3", "ADAR", "ADD1", "ADD3", "ADH5", "ADNP", "ADPGK", "ADPRHL2", "ADRM1", "ADSS", "AFDN", "AFG3L2", "AGK", "AGL", "AGPAT1", "AGPAT5", "AGPS", "AHCY", "AHCYL1", "AHNAK", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AKAP12", "AKAP13", "AKAP8", "AKAP8L", "AKR1A1", "AKR7A2", "AKT2", "ALDH18A1", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDOA", "ALDOC", "ALG1", "ALG11", "ALG12", "ALKBH5", "ALYREF", "AMOT", "ANAPC1", "ANAPC16", "ANAPC2", "ANAPC5", "ANAPC7", "ANGEL1", "ANKFY1", "ANKLE2", "ANKRD17", "ANO6", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA3", "ANXA4", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP1M1", "AP1S2", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "AP3S1", "APEH", "APEX1", "API5", "APLP2", "APMAP", "APOL2", "APOO", "APOOL", "APP", "APRT", "AQR", "ARAF", "ARCN1", "ARF4", "ARF6", "ARFGAP1", "ARFGAP2", "ARFIP1", "ARFIP2", "ARGLU1", "ARHGAP1", "ARHGAP17", "ARHGDIA", "ARHGEF2", "ARID1A", "ARIH1", "ARIH2", "ARL1", "ARL2", "ARL3", "ARL6IP1", "ARL6IP5", "ARL6IP6", "ARMC10", "ARMC8", "ARMCX3", "ARPC1A", "ARPC2", "ARPC3", "ARPC4", "ARPC5", "ASAH1", "ASCC2", "ASCC3", "ASNA1", "ASPH", "ATAD1", "ATAD3A", "ATAD3B", "ATG3", "ATG7", "ATG9A", "ATL2", "ATP13A1", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6", "ATP6AP1", "ATP6AP2", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1D", "ATP6V1E1", "ATP6V1H", "ATP7B", "ATPAF1", "ATPIF1", "ATRIP", "ATXN10", "ATXN2L", "AUP1", "AURKA", "AURKB", "B3GALT6", "B4GAT1", "BABAM1", "BAG2", "BAG5", "BAG6", "BAIAP2", "BAK1", "BANF1", "BANP", "BASP1", "BAZ1A", "BAZ1B", "BCAP31", "BCAS2", "BCCIP", "BCL2L13", "BCLAF1", "BCS1L", "BICD2", "BIRC6", "BMS1", "BNIP1", "BOD1", "BOLA2*", "BOP1", "BPHL", "BRAP", "BRD2", "BRI3BP", "BRIX1", "BSG", "BTF3", "BUB1B", "BUB3", "BUD23", "BUD31", "BYSL", "C12orf73", "C17orf75", "C19orf70", "C1QBP", "C1orf35", "C21orf59", "C2CD5", "CAB39", "CACYBP", "CAD", "CALD1", "CALM3", "CALR", "CALU", "CAMK1", "CAMK2G", "CAND1", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPRIN1", "CAPZA1", "CAPZA2", "CAPZB", "CARS2", "CASK", "CAST", "CBX1", "CBX3", "CBX5", "CBX8", "CCAR1", "CCAR2", "CCDC124", "CCDC134", "CCDC22", "CCDC47", "CCDC86", "CCNB1", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2AP", "CD2BP2", "CD320", "CD47", "CDC16", "CDC20", "CDC23", "CDC27", "CDC34", "CDC37", "CDC40", "CDC42", "CDC5L", "CDC7", "CDC73", "CDCA2", "CDCA8", "CDH2", "CDIPT", "CDK1", "CDK2", "CDK4", "CDK5", "CDK5RAP3", "CDK6", "CDKAL1", "CDKN2A", "CDS2", "CEBPZ", "CECR2", "CELF2", "CENPI", "CENPP", "CENPV", "CEP290", "CEP44", "CEP55", "CERS1", "CERS2", "CETN2", "CFAP20", "CFL1", "CFL2", "CHAF1A", "CHAF1B", "CHAMP1", "CHCHD3", "CHD1", "CHD4", "CHERP", "CHID1", "CHMP1A", "CHMP2A", "CHMP2B", "CHMP3", "CHMP4B", "CHMP5", "CHMP7", "CHORDC1", "CHRAC1", "CHST14", "CHTF18", "CIAPIN1", "CIRBP", "CISD1", "CISD2", "CKAP2", "CKAP4", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLCC1", "CLCN3", "CLCN7", "CLGN", "CLIC1", "CLIC4", "CLINT1", "CLN5", "CLNS1A", "CLPB", "CLPP", "CLPTM1", "CLPX", "CLTA", "CLTC", "CLU", "CMPK1", "CNN3", "CNNM4", "CNOT1", "CNOT10", "CNOT11", "CNOT2", "CNOT9", "CNP", "CNPY2", "COA3", "COA7", "COASY", "COG3", "COG4", "COIL", "COLEC12", "COLGALT1", "COMMD1", "COMT", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS7A", "COPS8", "COPZ1", "COQ8A", "COQ9", "CORO1B", "CORO1C", "CORO7", "COTL1", "COX18", "COX2", "COX4I1", "COX5A", "COX5B", "COX6C", "COX7A2", "CPNE1", "CPNE3", "CPOX", "CPSF1", "CPSF2", "CPSF3", "CPSF6", "CPSF7", "CPT1A", "CPT2", "CRK", "CRKL", "CRNKL1", "CROT", "CRTAP", "CS", "CSDE1", "CSE1L", "CSK", "CSNK1A1", "CSNK2A2", "CSNK2B", "CSRP2", "CSTB", "CSTF2", "CTBP1", "CTBP2", "CTCF", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTR9", "CTSA", "CTSB", "CTSC", "CTTN", "CTTNBP2NL", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CWC15", "CWC27", "CWF19L1", "CXorf56", "CXorf57", "CYB5B", "CYB5R1", "CYB5R3", "CYC1", "CYFIP1", "CYFIP2", "CYP51A1", "DAD1", "DAG1", "DAP3", "DARS", "DARS2", "DAXX", "DAZAP1", "DBN1", "DBNL", "DBT", "DCAF13", "DCAF16", "DCAF7", "DCP1B", "DCPS", "DCTN1", "DCTN2", "DCTN3", "DCTN4", "DCTPP1", "DCUN1D1", "DCUN1D5", "DCXR", "DDAH2", "DDB1", "DDI2", "DDOST", "DDRGK1", "DDX1", "DDX17", "DDX18", "DDX20", "DDX21", "DDX23", "DDX24", "DDX27", "DDX28", "DDX39A", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX5", "DDX50", "DDX51", "DDX52", "DDX54", "DDX55", "DDX56", "DDX6", "DEGS1", "DEK", "DERL1", "DERL2", "DFFA", "DGKE", "DHCR24", "DHCR7", "DHFR", "DHRS1", "DHRS4", "DHRS7", "DHRS7B", "DHX15", "DHX16", "DHX29", "DHX30", "DHX36", "DHX37", "DHX38", "DHX8", "DHX9", "DIABLO", "DIAPH1", "DIAPH2", "DIDO1", "DIMT1", "DIS3", "DKC1", "DLAT", "DLD", "DLG3", "DLGAP5", "DLST", "DNAAF5", "DNAJA1", "DNAJA3", "DNAJB1", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC13", "DNAJC19", "DNAJC2", "DNAJC3", "DNAJC8", "DNAJC9", "DNM1L", "DNM2", "DNMT1", "DNTTIP2", "DOCK7", "DOLPP1", "DPAGT1", "DPM1", "DPP9", "DPYSL2", "DPYSL5", "DRG1", "DSC3", "DSG2", "DSP", "DST", "DSTN", "DTYMK", "DUSP3", "DUT", "DYM", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNC1LI2", "DYNLL2", "EARS2", "EBNA1BP2", "ECE1", "ECH1", "ECHS1", "ECI1", "ECI2", "ECSIT", "EDC3", "EDC4", "EDF1", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EFL1", "EFTUD2", "EHD1", "EHD4", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B5", "EIF2D", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5A", "EIF6", "ELAC2", "ELAVL1", "ELOA", "ELOB", "ELOC", "ELP1", "ELP2", "ELP3", "EMC1", "EMC2", "EMC4", "EMC7", "EMD", "EMG1", "EML4", "ENAH", "ENO1", "ENO2", "EPB41", "EPB41L2", "EPB41L3", "EPB41L5", "EPDR1", "EPHA7", "EPHX1", "EPHX2", "EPPK1", "EPRS", "EPS15L1", "ERAL1", "ERAP1", "ERC1", "ERCC2", "ERCC3", "ERCC6L", "ERGIC2", "ERGIC3", "ERH", "ERLIN1", "ERLIN2", "ERMP1", "ERO1A", "ERP29", "ERP44", "ESD", "ESF1", "ESPL1", "ESYT1", "ESYT2", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXO1", "EXOC2", "EXOC3", "EXOC5", "EXOC6", "EXOC6B", "EXOC7", "EXOC8", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC9", "EZR", "F11R", "FABP5", "FADS2", "FAF1", "FAF2", "FAHD1", "FAM162A", "FAM208A", "FAM210A", "FAM3C", "FAM49B", "FAM98A", "FAM98B", "FANCD2", "FANCI", "FAR1", "FARP1", "FARS2", "FARSA", "FARSB", "FASN", "FASTKD2", "FBL", "FBXO21", "FBXO22", "FCGRT", "FDFT1", "FDXR", "FECH", "FEN1", "FERMT2", "FGFR1OP", "FH", "FHL1", "FHOD1", "FIP1L1", "FIS1", "FKBP10", "FKBP14", "FKBP1A", "FKBP2", "FKBP4", "FKBP7", "FKBP8", "FKBP9", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FMR1", "FNTA", "FNTB", "FOXRED1", "FSCN1", "FTL", "FTO", "FTSJ3", "FUCA1", "FUCA2", "FUNDC2", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GADD45GIP1", "GAK", "GAL", "GALNT1", "GALNT2", "GALNT4", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GATAD2A", "GATAD2B", "GBA", "GBF1", "GCAT", "GCC2", "GCDH", "GCLC", "GCN1", "GDAP1", "GDI1", "GDI2", "GDPD1", "GEMIN4", "GEMIN5", "GET4", "GFM1", "GGCX", "GGH", "GHDC", "GHITM", "GIGYF2", "GINS2", "GINS3", "GINS4", "GLA", "GLB1", "GLDC", "GLG1", "GLMN", "GLOD4", "GLRX3", "GLS", "GLT8D1", "GLUD1", "GLYR1", "GM2A", "GNA13", "GNAI2", "GNAI3", "GNG12", "GNL2", "GNL3", "GNL3L", "GNPAT", "GNS", "GOLGA2", "GOLGA3", "GOLGA5", "GOLGB1", "GOLIM4", "GOLM1", "GOLPH3", "GOLT1B", "GOPC", "GORASP2", "GOSR1", "GOT2", "GPAA1", "GPAM", "GPAT4", "GPATCH4", "GPD2", "GPHN", "GPI", "GPKOW", "GPR107", "GPR89B", "GPS1", "GPT2", "GRAMD1A", "GRB2", "GRHPR", "GRIPAP1", "GRPEL1", "GRSF1", "GRWD1", "GSR", "GSTK1", "GSTM3", "GTF2B", "GTF2E1", "GTF2F1", "GTF3C1", "GTF3C2", "GTF3C3", "GTPBP1", "GTPBP10", "GTPBP3", "GTPBP4", "GUF1", "GYG1", "GYS1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACD2", "HACD3", "HACL1", "HADH", "HADHA", "HADHB", "HAT1", "HAUS1", "HAUS3", "HAUS4", "HAUS5", "HCCS", "HCFC1", "HDAC1", "HDAC2", "HDGF", "HDHD5", "HDLBP", "HEATR1", "HEBP2", "HELLS", "HEXA", "HEXB", "HGS", "HIBADH", "HIBCH", "HIKESHI", "HINT2", "HIRIP3", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLTF", "HM13", "HMCES", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMGCL", "HMGCR", "HMGN2", "HMMR", "HMOX1", "HMOX2", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPM", "HNRNPR", "HNRNPU", "HP1BP3", "HPS6", "HS2ST1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSDL1", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA13", "HSPA14", "HSPA1B", "HSPA2", "HSPA4", "HSPA8", "HSPA9", "HSPB1", "HSPD1", "HSPE1", "HSPH1", "HTATSF1", "HTRA2", "HUS1", "HUWE1", "HYOU1", "IARS", "IARS2", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDI1", "IFT27", "IGF2BP1", "IGF2BP3", "IGF2R", "IK", "IKBIP", "IKBKG", "ILF2", "ILF3", "ILK", "ILVBL", "IMMT", "IMP3", "IMP4", "IMPAD1", "IMPDH1", "IMPDH2", "INA", "INCENP", "INTS11", "INTS14", "INTS3", "INTS7", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IQGAP2", "ISOC1", "IST1", "ITCH", "ITGB1", "ITM2C", "IVD", "JAGN1", "JUP", "KARS", "KAT7", "KCTD12", "KCTD5", "KDELC2", "KDELR1", "KDM1A", "KDM1B", "KDM3B", "KDSR", "KHDRBS1", "KIAA0319L", "KIAA0368", "KIAA0391", "KIAA1468", "KIF11", "KIF14", "KIF15", "KIF18B", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF4A", "KIF5B", "KIFBP", "KIFC1", "KIN", "KLC1", "KLC2", "KLC4", "KMT2A", "KNTC1", "KPNA1", "KPNA2", "KPNA3", "KPNA6", "KPNB1", "KRI1", "KRR1", "KTN1", "L2HGDH", "LAMP1", "LAMP2", "LAMTOR1", "LANCL2", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LAS1L", "LASP1", "LBR", "LDAH", "LDHA", "LDHB", "LEMD2", "LEMD3", "LETM1", "LGALS3BP", "LGMN", "LIG1", "LIG3", "LIMA1", "LIPA", "LMAN2", "LMF2", "LMNA", "LMNB1", "LMNB2", "LNPEP", "LNPK", "LONP1", "LPCAT1", "LPCAT3", "LPGAT1", "LRBA", "LRP1", "LRPAP1", "LRPPRC", "LRRC59", "LRWD1", "LSM2", "LSM3", "LSM4", "LSM6", "LSM7", "LSS", "LTA4H", "LTV1", "LUC7L", "LUC7L2", "LYAR", "LYPLA1", "LYSMD3", "M6PR", "MACF1", "MAD2L1", "MAGED2", "MAGT1", "MAIP1", "MAK16", "MAN1A1", "MAN2A1", "MAN2B1", "MANF", "MAP1B", "MAP1S", "MAP2K2", "MAP4", "MAPK1", "MAPK14", "MAPRE1", "MAPRE2", "MARC1", "MARCH5", "MARS", "MASTL", "MAT2A", "MAT2B", "MATR3", "MAU2", "MAVS", "MBD3", "MBOAT7", "MCAT", "MCCC1", "MCCC2", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCU", "MCUR1", "MDC1", "MDH1", "MDH2", "MDN1", "ME1", "ME2", "MECP2", "MED21", "MED23", "MED24", "MED25", "MEPCE", "METTL13", "METTL14", "METTL3", "METTL7A", "METTL7B", "METTL9", "MFN1", "MFN2", "MGME1", "MGST2", "MGST3", "MIA2", "MIA3", "MICU1", "MICU2", "MIF", "MINDY3", "MIPEP", "MKI67", "MLEC", "MMAB", "MMS19", "MOB4", "MOGS", "MORF4L1", "MOSPD2", "MOV10", "MPC2", "MPDU1", "MPG", "MPHOSPH10", "MPP1", "MPP6", "MPRIP", "MPST", "MPV17", "MPV17L2", "MRC2", "MRE11", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL14", "MRPL15", "MRPL17", "MRPL19", "MRPL21", "MRPL22", "MRPL23", "MRPL24", "MRPL28", "MRPL3", "MRPL37", "MRPL38", "MRPL39", "MRPL40", "MRPL44", "MRPL45", "MRPL46", "MRPL50", "MRPL53", "MRPL55", "MRPL58", "MRPL9", "MRPS11", "MRPS15", "MRPS16", "MRPS18A", "MRPS22", "MRPS23", "MRPS25", "MRPS27", "MRPS30", "MRPS31", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRPS9", "MRRF", "MRTO4", "MSH2", "MSH3", "MSH6", "MSI2", "MSMO1", "MSN", "MSTO1", "MTA1", "MTA2", "MTBP", "MTCH1", "MTCH2", "MTDH", "MTFP1", "MTHFD1", "MTHFD1L", "MTHFD2", "MTMR14", "MTMR2", "MTOR", "MTPAP", "MTPN", "MTX1", "MTX2", "MUT", "MVK", "MYBBP1A", "MYCBP", "MYDGF", "MYEF2", "MYG1", "MYH10", "MYH9", "MYL6", "MYO1B", "MYO1C", "MYO1D", "MYO6", "NAA15", "NAA25", "NAA35", "NAA40", "NAA50", "NADK2", "NAF1", "NAGA", "NAGLU", "NAMPT", "NAP1L1", "NAP1L4", "NAPA", "NAPG", "NASP", "NAT10", "NAXE", "NCAPD2", "NCAPD3", "NCAPG", "NCAPG2", "NCAPH", "NCBP1", "NCBP3", "NCDN", "NCKAP1", "NCL", "NCLN", "NCSTN", "ND1", "NDC1", "NDUFA11", "NDUFA13", "NDUFA4", "NDUFA5", "NDUFA7", "NDUFA8", "NDUFA9", "NDUFAF2", "NDUFAF3", "NDUFAF4", "NDUFAF7", "NDUFB1", "NDUFB10", "NDUFB3", "NDUFB4", "NDUFB5", "NDUFB6", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS6", "NDUFS7", "NDUFS8", "NDUFV1", "NDUFV2", "NECAP2", "NEFL", "NEFM", "NEK9", "NELFCD", "NELFE", "NENF", "NES", "NFU1", "NGDN", "NHP2", "NIFK", "NIP7", "NIPSNAP1", "NIPSNAP2", "NKRF", "NLE1", "NLN", "NLRX1", "NME1", "NMT1", "NNT", "NOA1", "NOB1", "NOC2L", "NOC3L", "NOC4L", "NOL10", "NOL11", "NOL6", "NOL7", "NOL8", "NOL9", "NOLC1", "NOM1", "NONO", "NOP14", "NOP16", "NOP2", "NOP53", "NOP56", "NOP58", "NOP9", "NOSIP", "NPC1", "NPC2", "NPLOC4", "NPM1", "NRDC", "NSA2", "NSD2", "NSDHL", "NSF", "NSMCE2", "NSUN2", "NSUN5", "NTHL1", "NUB1", "NUBP2", "NUBPL", "NUCB1", "NUCB2", "NUCKS1", "NUDC", "NUDCD2", "NUDT1", "NUDT21", "NUDT9", "NUF2", "NUFIP2", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP160", "NUP188", "NUP205", "NUP210", "NUP214", "NUP35", "NUP37", "NUP43", "NUP50", "NUP54", "NUP58", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NUTF2", "NVL", "NXF1", "OAT", "OCIAD1", "OCLN", "OCRL", "OGDH", "OGT", "OLA1", "OPA1", "OPA3", "OSBP", "OSBPL3", "OSBPL6", "OSBPL8", "OSBPL9", "OSGEP", "OXA1L", "OXCT1", "OXSR1", "P3H1", "P3H4", "P4HA1", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PAF1", "PAFAH1B1", "PAFAH1B2", "PAFAH1B3", "PAIP1", "PAK1IP1", "PAK2", "PALLD", "PARG", "PARK7", "PARN", "PARP1", "PATL1", "PAWR", "PBRM1", "PC", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCID2", "PCK2", "PCLAF", "PCM1", "PCNA", "PCNP", "PCYOX1", "PDAP1", "PDCD11", "PDCD6", "PDCD6IP", "PDCL3", "PDE12", "PDE6D", "PDHA1", "PDHB", "PDIA3", "PDIA4", "PDIA5", "PDIA6", "PDK3", "PDLIM1", "PDLIM5", "PDLIM7", "PDPR", "PDS5A", "PDS5B", "PDXDC1", "PDXK", "PECR", "PEF1", "PELP1", "PES1", "PEX11A", "PEX14", "PEX16", "PEX19", "PEX5", "PFDN2", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGK1", "PGM1", "PGM2", "PGRMC1", "PGRMC2", "PHAX", "PHB", "PHB2", "PHC2", "PHF5A", "PHF6", "PHIP", "PHKA1", "PI4K2A", "PI4KB", "PIBF1", "PICALM", "PIGK", "PIGS", "PIGT", "PIGU", "PIK3R4", "PIN4", "PINX1", "PIP4K2C", "PISD", "PITPNB", "PITRM1", "PKM", "PKMYT1", "PKN1", "PKN2", "PLA2G15", "PLAA", "PLBD2", "PLCG1", "PLD3", "PLD6", "PLEC", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLRG1", "PLS3", "PMF1", "PMPCA", "PMPCB", "PMVK", "PNKP", "PNN", "PNO1", "PNP", "PNPLA6", "PNPT1", "PODXL", "POFUT1", "POGZ", "POLA1", "POLA2", "POLD1", "POLD2", "POLD3", "POLDIP2", "POLDIP3", "POLE", "POLE3", "POLE4", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2A", "POLR2B", "POLR2C", "POLR2D", "POLR2E", "POLR2F", "POLR2G", "POLR2L", "POLR3A", "POLR3C", "POLRMT", "PON2", "POP1", "POR", "PPA2", "PPAN", "PPIB", "PPID", "PPIF", "PPIH", "PPIL1", "PPIL3", "PPOX", "PPP1CA", "PPP1CB", "PPP1R10", "PPP1R12A", "PPP1R8", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP2R5E", "PPP3CA", "PPP4C", "PPP4R1", "PPP4R3A", "PPP5C", "PPP6C", "PPT1", "PPT2", "PPWD1", "PRAF2", "PRC1", "PRCC", "PRCP", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PREPL", "PRIM1", "PRIM2", "PRKAA2", "PRKACA", "PRKAG1", "PRKAR1A", "PRKAR2A", "PRKCB", "PRKCSH", "PRKDC", "PRKRA", "PRMT1", "PRMT5", "PRPF19", "PRPF31", "PRPF38B", "PRPF39", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPSAP1", "PRPSAP2", "PRRC1", "PRRC2C", "PSAP", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD6", "PSMD7", "PSMD8", "PSMD9", "PSME1", "PSME2", "PSME3", "PSME4", "PSMG1", "PSPC1", "PTBP1", "PTCD3", "PTDSS1", "PTGES2", "PTGES3", "PTK7", "PTPA", "PTPMT1", "PTPN1", "PTPRF", "PTRH2", "PUM1", "PUM3", "PURA", "PWP1", "PWP2", "PXMP2", "PXN", "PYCR1", "PYCR2", "PYCR3", "PYGB", "PYGL", "QARS", "QKI", "QRSL1", "QSOX2", "QTRT2", "RAB10", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB1B", "RAB21", "RAB24", "RAB31", "RAB39A", "RAB3GAP1", "RAB3GAP2", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RAB8A", "RAB9A", "RABAC1", "RABEP1", "RABEPK", "RABGAP1", "RABL6", "RAC1", "RACGAP1", "RACK1", "RAD21", "RAD23A", "RAD23B", "RAD50", "RAE1", "RAI14", "RALA", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP9", "RANGAP1", "RAP2B", "RAPGEF2", "RARS", "RARS2", "RBBP5", "RBBP6", "RBBP7", "RBM10", "RBM12", "RBM14", "RBM17", "RBM19", "RBM22", "RBM25", "RBM27", "RBM28", "RBM34", "RBM39", "RBM4", "RBM5", "RBM8A", "RBMX", "RBP1", "RCC1", "RCC2", "RCL1", "RCN1", "RCN2", "RDH11", "RDH13", "RDH14", "RDX", "RECQL", "REEP4", "REEP5", "RER1", "RETSAT", "REXO4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RFT1", "RHBDD2", "RHEB", "RHOG", "RHOT1", "RHOT2", "RIDA", "RIF1", "RINT1", "RMC1", "RMDN1", "RMDN3", "RMND1", "RNASEH2A", "RNASET2", "RNF139", "RNF14", "RNF20", "RNF219", "RNF40", "ROCK1", "RPA1", "RPA2", "RPAP3", "RPF1", "RPF2", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPN1", "RPN2", "RPP30", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS28", "RPS29", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RPTOR", "RPUSD3", "RRBP1", "RRM1", "RRM2", "RRP1", "RRP12", "RRP15", "RRP1B", "RRP36", "RRP8", "RRP9", "RRS1", "RSL1D1", "RSL24D1", "RSU1", "RTCB", "RTN2", "RTN3", "RTN4", "RTN4IP1", "RTRAF", "RUFY1", "RUVBL1", "RUVBL2", "S100A11", "S100A13", "SACM1L", "SAE1", "SAFB", "SAFB2", "SAMD4B", "SAMHD1", "SAMM50", "SAP18", "SAR1A", "SARM1", "SARNP", "SARS2", "SART1", "SART3", "SBDS", "SCAF1", "SCAMP1", "SCAMP2", "SCAMP3", "SCARB1", "SCARB2", "SCCPDH", "SCD", "SCFD1", "SCML2", "SCO1", "SCO2", "SCP2", "SCRIB", "SCRN1", "SDAD1", "SDCBP", "SDF4", "SDHA", "SDHB", "SEC11A", "SEC16A", "SEC22B", "SEC23A", "SEC23B", "SEC23IP", "SEC24A", "SEC24B", "SEC24C", "SEC24D", "SEC31A", "SEC61A1", "SEC61B", "SEC61G", "SEC62", "SEC63", "SEH1L", "SEL1L", "SENP3", "SEPHS1", "SEPT11", "SEPT2", "SEPT6", "SEPT7", "SEPT9", "SERBP1", "SERPINB6", "SERPINH1", "SET", "SEZ6L2", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFXN1", "SFXN2", "SFXN4", "SGPL1", "SGTA", "SH3GL1", "SH3GLB1", "SHMT2", "SIGMAR1", "SIN3A", "SIRT1", "SKIV2L2", "SKP1", "SKP2", "SLC16A1", "SLC19A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A17", "SLC25A19", "SLC25A20", "SLC25A21", "SLC25A22", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A33", "SLC25A4", "SLC25A40", "SLC25A42", "SLC25A5", "SLC25A6", "SLC27A4", "SLC30A5", "SLC30A6", "SLC33A1", "SLC35A4", "SLC35B2", "SLC39A14", "SLC3A2", "SLC4A7", "SLC6A15", "SLC9A3R1", "SLFN11", "SLIRP", "SLK", "SLTM", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC6", "SMG5", "SMN1*", "SMNDC1", "SMPD4", "SMU1", "SNAP23", "SND1", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPC", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNW1", "SNX1", "SNX12", "SNX17", "SNX19", "SNX2", "SNX27", "SNX3", "SNX4", "SNX5", "SNX6", "SNX9", "SOAT1", "SOD2", "SON", "SORD", "SPAG9", "SPART", "SPATA5", "SPATA5L1", "SPC24", "SPC25", "SPCS2", "SPECC1L", "SPEN", "SPHK2", "SPNS1", "SPTAN1", "SPTBN1", "SPTBN2", "SPTLC1", "SPTLC2", "SQLE", "SQSTM1", "SRCAP", "SREK1", "SRI", "SRP14", "SRP54", "SRP68", "SRP72", "SRP9", "SRPK1", "SRPK2", "SRPRA", "SRPRB", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF3", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSNA1", "SSR1", "SSR4", "SSRP1", "STAG1", "STAG2", "STAM", "STAMBP", "STARD3", "STARD3NL", "STARD7", "STAT1", "STAT3", "STAU1", "STAU2", "STIM1", "STIP1", "STK26", "STK4", "STMN1", "STOM", "STOML2", "STRAP", "STRBP", "STRN", "STT3A", "STT3B", "STX10", "STX12", "STX18", "STX3", "STX4", "STX5", "STX7", "STX8", "STXBP3", "STXBP4", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGP2", "SUGT1", "SUN1", "SUN2", "SUPT16H", "SUPT5H", "SUPT6H", "SUPV3L1", "SURF4", "SURF6", "SUZ12", "SV2A", "SYAP1", "SYMPK", "SYNCRIP", "SYNE2", "SYNGR2", "SYNJ2BP", "SYS1", "TAB1", "TACC3", "TADA3", "TAF15", "TAF6L", "TAOK1", "TAP1", "TARDBP", "TARS2", "TBCA", "TBCB", "TBCD", "TBCE", "TBL2", "TBL3", "TBRG4", "TCEA1", "TCERG1", "TCOF1", "TCP1", "TDRKH", "TECR", "TELO2", "TERF2IP", "TES", "TEX10", "TEX264", "TFAM", "TFB1M", "TFCP2", "TFG", "TFIP11", "TFRC", "TGOLN2", "THOC1", "THOC2", "THOC3", "THOC5", "THOC6", "THOP1", "THRAP3", "THUMPD3", "TIA1", "TIAL1", "TIGAR", "TIMELESS", "TIMM10", "TIMM10B", "TIMM13", "TIMM17A", "TIMM17B", "TIMM23", "TIMM44", "TIMM50", "TIMM8B", "TIMM9", "TJP1", "TKT", "TLN1", "TM9SF2", "TM9SF4", "TMA16", "TMCO1", "TMED10", "TMED2", "TMED4", "TMED5", "TMED7", "TMED9", "TMEM109", "TMEM126A", "TMEM126B", "TMEM14C", "TMEM165", "TMEM167A", "TMEM192", "TMEM199", "TMEM201", "TMEM214", "TMEM230", "TMEM259", "TMEM30A", "TMEM33", "TMEM38B", "TMEM43", "TMEM59", "TMEM65", "TMEM87A", "TMEM97", "TMF1", "TMOD1", "TMOD3", "TMPO", "TMPO", "TMTC3", "TMX1", "TMX2", "TMX3", "TMX4", "TNKS1BP1", "TNPO1", "TNPO3", "TOE1", "TOMM20", "TOMM22", "TOMM34", "TOMM40", "TOMM5", "TOMM70", "TOP1", "TOP2A", "TOP2B", "TOR1AIP1", "TOR1B", "TOR3A", "TOX4", "TP53", "TPD52", "TPM1", "TPM3", "TPM4", "TPP1", "TPP2", "TPR", "TPT1", "TPX2", "TRA2A", "TRA2B", "TRAF2", "TRAM1", "TRAP1", "TRAPPC5", "TRIM21", "TRIM25", "TRIM28", "TRIP12", "TRIP13", "TRMT10C", "TRMU", "TROVE2", "TRRAP", "TRUB1", "TSFM", "TSG101", "TSN", "TSNAX", "TSPAN10", "TSPAN3", "TSPAN6", "TSPO", "TSR1", "TST", "TTC1", "TTC19", "TTC26", "TTC37", "TTK", "TTLL12", "TTYH3", "TUBB", "TUBB2A", "TUBB2B", "TUBB3", "TUBB4B", "TUBB6", "TUBGCP2", "TUBGCP3", "TUBGCP4", "TUFM", "TWF1", "TWF2", "TWISTNB", "TWNK", "TXLNG", "TXNDC12", "TXNDC5", "TXNDC9", "TXNL1", "TXNRD1", "TYMS", "U2AF1", "U2AF2", "UBA1", "UBA2", "UBAC1", "UBAP2L", "UBE2J1", "UBE2K", "UBE2L3", "UBE2N", "UBE2O", "UBE2S", "UBE3A", "UBE4A", "UBE4B", "UBLCP1", "UBP1", "UBQLN2", "UBQLN4", "UBR4", "UBR5", "UBTF", "UBXN1", "UBXN4", "UBXN7", "UCHL5", "UFD1", "UFL1", "UFM1", "UGCG", "UGGT1", "UGT8", "UHRF1", "ULK3", "UNC119", "UNC119B", "UNC45A", "UNG", "UPF1", "UQCC2", "UQCR10", "UQCRB", "UQCRC1", "UQCRC2", "UQCRQ", "URB1", "USO1", "USP10", "USP11", "USP14", "USP28", "USP36", "USP39", "USP47", "USP48", "USP5", "USP7", "USP9X", "UTP11", "UTP14A", "UTP15", "UTP18", "UTP20", "UTP3", "UTP4", "UTP6", "UTRN", "UXT", "VAMP7", "VANGL1", "VAPA", "VAPB", "VARS1", "VAT1", "VBP1", "VCL", "VCP", "VDAC1", "VDAC2", "VDAC3", "VIM", "VIRMA", "VKORC1L1", "VMP1", "VPS13A", "VPS13D", "VPS16", "VPS18", "VPS26A", "VPS29", "VPS33A", "VPS33B", "VPS35", "VPS37B", "VPS4A", "VPS4B", "VPS51", "VPS52", "VPS53", "VRK1", "VRK3", "WAPL", "WASHC5", "WBP11", "WBP2", "WDHD1", "WDR1", "WDR11", "WDR12", "WDR18", "WDR26", "WDR3", "WDR34", "WDR36", "WDR41", "WDR43", "WDR46", "WDR48", "WDR5", "WDR61", "WDR70", "WDR75", "WDR77", "WDR82", "WFS1", "WIPI2", "WIZ", "WLS", "XAB2", "XPNPEP3", "XPO1", "XPO4", "XPO5", "XPO7", "XPOT", "XRCC1", "XRCC5", "XRCC6", "XRN2", "YARS", "YARS2", "YBX1", "YBX3", "YIF1A", "YIPF3", "YIPF4", "YIPF5", "YKT6", "YLPM1", "YME1L1", "YRDC", "YTHDC1", "YTHDC2", "YTHDF3", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2", "ZC3H14", "ZC3H18", "ZC3HC1", "ZCRB1", "ZDHHC13", "ZFR", "ZFYVE16", "ZMPSTE24", "ZMYM2", "ZNF207", "ZNF326", "ZNF622", "ZNF638", "ZPR1", "ZW10", "ZWINT", "ZYX"], "leading_proteins": ["AARS2", "ABCB1", "ABCB7", "ABCC1", "ABCD3", "ABHD10", "ABHD12", "ACAT2", "ACBD5", "ACOX1", "ACOX3", "ACP2", "ACSL3", "ACTL6A", "ADPGK", "AGK", "AGPAT5", "AGPS", "AIFM1", "ALDH3A2", "ALDH5A1", "ALG1", "ALG11", "ALG12", "ANAPC16", "ANAPC2", "ANAPC5", "ANAPC7", "ANKLE2", "ANO6", "ANXA1", "APLP2", "APOL2", "APOO", "APOOL", "APP", "ARF4", "ARFIP2", "ARL1", "ARL3", "ARL6IP1", "ARL6IP5", "ARL6IP6", "ARMCX3", "ASAH1", "ASNA1", "ATAD1", "ATAD3A", "ATAD3B", "ATL2", "ATP13A1", "ATP1A1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP5B", "ATP5F1", "ATP5I", "ATP5L", "ATP6", "ATP6AP1", "ATP6AP2", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1C1", "ATP6V1E1", "ATP7B", "ATPAF1", "AURKB", "B3GALT6", "B4GAT1", "BAIAP2", "BCAP31", "BCL2L13", "BCS1L", "BNIP1", "BRI3BP", "BSG", "BUB1B", "C12orf73", "C19orf70", "C1QBP", "CACYBP", "CALU", "CANX", "CAPZA1", "CBX1", "CBX5", "CCDC47", "CD320", "CD47", "CDC16", "CDCA8", "CDIPT", "CDKAL1", "CDS2", "CEP290", "CERS1", "CERS2", "CETN2", "CHCHD3", "CHRAC1", "CHST14", "CISD1", "CKAP4", "CLCC1", "CLCN3", "CLCN7", "CLN5", "CLPP", "CLPTM1", "CLU", "CNNM4", "CNOT1", "CNOT2", "COA3", "COMMD1", "COPS4", "COQ8A", "COQ9", "COX18", "COX2", "COX4I1", "COX5A", "COX7A2", "CPOX", "CPT1A", "CPT2", "CRTAP", "CSNK1A1", "CTNND1", "CTSA", "CTSB", "CYB5B", "CYC1", "CYP51A1", "DARS2", "DCAF16", "DCAF7", "DCTPP1", "DDRGK1", "DDX28", "DEGS1", "DERL1", "DERL2", "DHCR24", "DHCR7", "DHFR", "DHRS1", "DHRS4", "DHRS7", "DHRS7B", "DIABLO", "DLD", "DNAJC1", "DNAJC19", "DNM2", "DOLPP1", "DPAGT1", "ECE1", "EMC2", "EMC4", "EMC7", "EMD", "EPDR1", "EPHX1", "ERAP1", "ERGIC2", "ERGIC3", "ERLIN1", "FADS2", "FAM162A", "FAM210A", "FAM49B", "FAR1", "FASN", "FDFT1", "FECH", "FIS1", "FKBP10", "FKBP14", "FKBP1A", "FKBP2", "FKBP7", "FKBP9", "FLOT1", "FLOT2", "FMR1", "FOXRED1", "FUCA1", "FUCA2", "FUNDC2", "GAA", "GADD45GIP1", "GAL", "GALNT1", "GALNT4", "GBA", "GDAP1", "GGCX", "GHITM", "GINS2", "GLA", "GLB1", "GLUD1", "GM2A", "GNPAT", "GOLGA5", "GOLGB1", "GOLIM4", "GOLPH3", "GOLT1B", "GOSR1", "GPAA1", "GPR107", "GPR89B", "HACD2", "HACD3", "HADH", "HADHA", "HAUS1", "HAUS3", "HAUS4", "HAUS5", "HCCS", "HEXA", "HK2", "HLA-A", "HLA-B", "HLA-C", "HMGCR", "HMOX1", "HMOX2", "HNRNPA3", "HNRNPR", "HPS6", "HS2ST1", "HSD17B11", "HSD17B12", "HSDL1", "HSDL2", "HSPA9", "HTRA2", "ICMT", "IDH2", "IKBIP", "ILVBL", "IMMT", "IMPAD1", "INA", "INCENP", "IPO9", "ISOC1", "ITCH", "ITGB1", "ITM2C", "JAGN1", "KDELR1", "KDSR", "KHDRBS1", "KIAA0319L", "KIF18B", "KPNA2", "KPNA3", "L2HGDH", "LAMP1", "LAMP2", "LBR", "LDAH", "LETM1", "LGALS3BP", "LGMN", "LMAN2", "LMF2", "LMNB1", "LMNB2", "LNPEP", "LONP1", "LPCAT1", "LPGAT1", "LRRC59", "LSM7", "LYSMD3", "MAGT1", "MAIP1", "MAPK14", "MAPRE2", "MATR3", "MBOAT7", "MCCC2", "MCL1", "MCUR1", "METTL7A", "METTL7B", "METTL9", "MFN1", "MFN2", "MGST2", "MGST3", "MIA2", "MICU2", "MIF", "MIPEP", "MOB4", "MOSPD2", "MOV10", "MPV17", "MPV17L2", "MRPL10", "MRPL45", "MRPL46", "MRPL50", "MRPS18A", "MRPS9", "MSMO1", "MTCH1", "MTCH2", "MTDH", "MTFP1", "MTX1", "NAGA", "NAGLU", "NAP1L1", "NCLN", "NCSTN", "ND1", "NDC1", "NDUFA11", "NDUFA13", "NDUFA4", "NDUFA8", "NDUFAF2", "NDUFB1", "NDUFB10", "NDUFB3", "NDUFB4", "NDUFB5", "NDUFB6", "NDUFB9", "NEFL", "NEFM", "NFU1", "NIPSNAP1", "NLN", "NLRX1", "NNT", "NPC1", "NSF", "NUCB1", "NUCB2", "NUDT9", "NUP107", "NUP160", "NUP35", "NUP37", "NUP43", "NUP85", "NUP98", "NXF1", "OCIAD1", "OCLN", "OLA1", "OPA1", "OPA3", "OSBPL3", "OXA1L", "P3H1", "P3H4", "P4HA1", "PABPN1", "PCM1", "PCYOX1", "PDE6D", "PDHB", "PECR", "PEX11A", "PEX14", "PEX16", "PEX19", "PEX5", "PFDN2", "PFDN6", "PGRMC1", "PGRMC2", "PHB", "PHB2", "PI4KB", "PIGK", "PIGU", "PISD", "PITRM1", "PLA2G15", "PLBD2", "PLD3", "PLD6", "PMF1", "PMPCA", "PNPLA6", "POLDIP2", "POLE3", "POLE4", "POLRMT", "PON2", "POR", "PPP2R1B", "PPT1", "PPT2", "PRAF2", "PRCP", "PREB", "PREPL", "PRKAA2", "PRKAG1", "PRKAR1A", "PSAP", "PSMB2", "PSMB4", "PSMB5", "PSMB6", "PTDSS1", "PTGES2", "PTPMT1", "PUM3", "PXMP2", "RAB10", "RAB1A", "RAB1B", "RAB24", "RAB31", "RAB5B", "RAB7A", "RAB9A", "RABAC1", "RABEPK", "RAE1", "RANBP2", "RCN2", "RDH13", "REEP4", "REEP5", "RER1", "RETSAT", "RFT1", "RHBDD2", "RHOT2", "RMND1", "RNASET2", "RNF139", "RNF40", "RPN1", "RTN2", "RTN3", "RTN4", "RTN4IP1", "RUVBL2", "SACM1L", "SAMM50", "SAR1A", "SCAMP2", "SCAMP3", "SCARB1", "SCARB2", "SCCPDH", "SCD", "SCFD1", "SCO1", "SCO2", "SCP2", "SDCBP", "SDF4", "SDHB", "SEC11A", "SEC22B", "SEC23A", "SEC23B", 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setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Cation transmembrane transporter activity 43 71 5.187415822532523 2.132322560380137e-07 25.62135922330097 70.51699029126213 1.766742880952279 0.2698419237572138 12.29126021871486 8.422243011776631 2.00238274385689 0.3706372466673562 5.424314362609549e-09 0.0007846366850434 0.0003405349499609 5.649191818158989e-07 1.1240456308693212e-08 +Inorganic molecular entity transmembrane transporter activity 44 77 5.07483708422482 3.878281405274122e-07 28.058252427184467 75.9635922330097 1.5031303400189615 0.2894264293069549 11.721339963426631 9.38477049228959 2.153051736566399 0.3821536813265525 5.518597068024107e-12 1.9132694004220426e-06 1.834728141555886e-05 1.4526474433550804e-08 1.3691325603243355e-11 +Active transmembrane transporter activity 48 71 4.999695167553645 5.742102355397003e-07 26.354368932038835 73.12621359223301 1.313035419122872 0.3239574057550545 11.878456281473593 8.663537710607383 1.88741562841277 0.3851687956916088 2.76908443967419e-09 0.072705670789428 0.0433269432657135 2.4249387162290465e-05 1.3995406844916112e-09 +Ion transmembrane transporter activity 64 101 4.900206355685737 9.57360475083436e-07 37.34466019417476 101.497572815534 2.0154097423383375 0.2561362875319209 17.172953606300336 11.579295798802024 2.277787478419462 0.3756175790939143 1.6058781250254433e-14 1.785841953589194e-07 1.2373248543488835e-06 4.4565485463310135e-11 5.0647039256234354e-14 +Anion transmembrane transporter activity 34 45 4.316372376089839 1.5861431728048103e-05 18.594660194174757 45.61893203883495 1.6222323024349488 0.2373683627198559 9.346785472607134 6.017202751823004 1.8117646078257517 0.3183345645365742 4.2244914422679974e-10 0.0003284154666529 0.0012481565311226 2.735293528137653e-07 7.81684329555055e-10 +Active ion transmembrane transporter activity 29 40 4.242596292463259 2.2094868808997248e-05 16.271844660194176 41.71116504854369 1.2957221273899948 0.3267733012969381 7.788084220174416 5.097264791179653 1.6571109350293016 0.3632481416270505 6.742441733140427e-06 0.4354616437047781 0.3096866051250833 0.0019480531003061 1.0104558285963934e-05 +Transporter activity 107 176 4.211257657226692 2.539528927725243e-05 62.22330097087379 172.27912621359224 2.173366592838491 0.2707201784543502 25.984753572620328 19.29276868436311 2.593156143256053 0.3916539604106395 2.7165866382942073e-23 1.1344177600947635e-09 1.2408318682157732e-08 1.8227740513755413e-14 4.5044637755683803e-23 +Organic anion transmembrane transporter activity 22 29 3.939938992171909 8.150233298964693e-05 12.951456310679612 30.182038834951456 1.56101282472555 0.2452312368187786 6.880574373146614 3.5222410835885483 1.575669523214114 0.314839840161206 6.435885065804881e-06 0.0627750690965546 0.0471171920041226 0.0001763752828709 9.175860148508649e-06 +Proton transmembrane transporter activity 19 35 3.8905810409247423 0.0001000044699694 12.769417475728156 35.478155339805824 1.2352045534927034 0.2879171268332734 5.319202861157036 2.7149368379617917 1.7021108079122016 0.3308025072902738 1.0406077819220392e-06 0.0053226708337122 0.0006737903450178 1.1994258904306193e-06 1.5052395979136103e-06 +Secondary active transmembrane transporter activity 18 22 3.7870986649289455 0.0001524165893571 9.080097087378642 21.490291262135923 1.2627683473613005 0.2947710034053126 5.466215032972134 3.0675886156990426 1.4241587428281404 0.3340388164945335 0.0006628723643317 0.3467229085425889 0.2040732901381184 0.0011235655849171 0.000858543924362 +Primary active transmembrane transporter activity 30 50 3.708924974828654 0.0002081410849581 17.696601941747574 52.529126213592235 1.0080198242353189 0.3544097082146772 7.649017203625277 6.455721193615876 1.66885648871365 0.3767837436492733 4.912656840182935e-07 0.1131277718078383 0.1061761164696546 0.0077005325850907 1.7642333034257368e-07 +Steroid binding 13 24 3.540323590276249 0.0003996367065692 8.424757281553399 21.398058252427184 1.4469817519716153 0.1523451695819165 3.035656818503787 2.066091501771892 1.85140774519605 0.2395996334984524 2.4008959575948043e-08 8.508689216563006e-05 9.61855521325839e-05 1.8490190568418689e-06 3.4790157518686385e-08 +Tetrapyrrole binding 11 17 3.456934219587486 0.0005463581987998 7.402912621359223 16.83252427184466 2.0044897428967667 0.1259264696495541 2.9589081005845346 2.0417036568087963 1.3464702305086589 0.2177422235164347 0.0007154556004602 0.0276250495673642 0.0145863017156454 3.634104334677723e-05 0.0008827713515558 +Organic acid transmembrane transporter activity 15 21 3.431095836138075 0.0006011481821615 8.592233009708737 21.276699029126213 1.5973629153049684 0.1905568538747131 4.4420473133518055 2.549726956007885 1.3213968531498468 0.2647933566957936 0.0037570631197801 0.0421554091664212 0.0268041613697724 0.0224299471021099 0.0045573147492828 +Nucleobase containing compound transmembrane transporter activity 13 14 3.342420624341492 0.0008305110452995 6.529126213592233 14.04126213592233 1.4296604886183193 0.212054291115069 3.2696940585469636 1.915888183904924 1.3255809572534116 0.2748813593420038 9.307579805744097e-08 0.1430638950507344 0.2638774705145789 9.070679410703562e-05 1.255822907430585e-07 +Metal ion transmembrane transporter activity 14 26 3.292791526239319 0.0009919799853099 9.563106796116504 24.67233009708738 0.8657396859235934 0.3700615753207195 4.93288923178502 4.839352380624028 1.4450904591933955 0.3424002804304004 0.0039505695187725 0.1162566833370341 0.3237138230889217 0.0260354813107655 0.0050540599320041 +Atpase coupled transmembrane transporter activity 12 21 3.155216310483627 0.0016037915100726 8.072815533980583 22.696601941747577 0.8561067713091313 0.3392846662603397 4.166386392056555 3.892074110340729 1.3163009809214623 0.3229730128136945 0.0012175308232882 1.0 1.0 0.4019903152362746 0.0003480102587118 +Protein transporter activity 13 16 3.145459447662871 0.0016582618246097 6.053398058252427 14.696601941747574 1.6882240898296943 0.1359359142649309 2.957968193176 1.443999336657768 1.4805047019217734 0.2345897542974644 1.0213132525044182e-05 0.0002227197090729 0.0016492758756177 0.0002602915372779 1.1546988473536831e-06 +Nucleotide transmembrane transporter activity 11 12 3.126682943252616 0.0017679047284293 5.606796116504855 12.029126213592232 1.4217258291760082 0.2036087501116975 3.0234925518113496 1.8899648667798992 1.291115513359647 0.2666064512499804 8.615383237550492e-09 0.0963063052639835 0.1820374447866984 6.761380561206551e-06 1.1429698611688268e-08 +Organophosphate ester transmembrane transporter activity 11 12 3.126682943252616 0.0017679047284293 5.665048543689321 12.143203883495143 1.4298365636921646 0.2056324024803549 3.029697948284232 1.927415248708952 1.2819429632405106 0.2680490563295835 1.5149805374122873e-08 0.1006582454154426 0.1898352204968973 9.113307661096915e-06 2.0072681169328492e-08 +Inorganic anion transmembrane transporter activity 15 20 3.1230411106750844 0.0017899274437769 7.427184466019417 19.274271844660195 1.0921593405593897 0.2441056926448881 3.717191605498929 3.7816647851785734 1.4014196343960104 0.2816216967014333 2.996329265221e-06 0.0001075756277076 0.0014691652083679 0.0002093285488015 4.063505284349851e-06 +Passive transmembrane transporter activity 15 35 3.058719162283278 0.0022228542196036 10.728155339805824 34.00242718446602 0.8598494327527568 0.3171523987434088 5.464704354730218 4.259483301090722 1.5882390061019254 0.3339692919660049 0.0021726828673697 0.0002061120351411 0.0045581119989154 0.0056900283119864 0.0028073275755896 +Serine hydrolase activity 11 19 3.0248392403748494 0.0024876531461139 6.934466019417476 18.83009708737864 1.2767207242593377 0.1489147276149277 2.386872767465543 1.965791668457755 1.709796217367629 0.2208345231085202 0.0059721842053909 0.2068720246529641 0.3686542667111886 0.0053877503342881 0.0069902627476053 +Oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen 12 24 2.973599978606328 0.0029432850384734 9.395631067961164 29.8373786407767 1.5709767518568172 0.2393367467664754 3.119976403291062 3.762391942431812 1.2135099906711824 0.3124947384976632 0.0010925446560275 0.0734458650364987 0.2215279004104483 0.0065275720448211 0.0014062020276394 +Molecular transducer activity 18 34 2.866041218096486 0.0041564012487154 10.91747572815534 33.40533980582524 1.343848990749489 0.2329582295822712 4.7124072380860955 5.830391636254363 1.6098335072319665 0.2956883791113679 0.6460253039470836 1.0 0.7086124400805833 0.4139711247314455 0.568595135181234 +Snap receptor activity 10 14 2.833104242883719 0.0046098350324135 5.803398058252427 13.6626213592233 0.8920027438628428 0.3386294703372389 3.103034547770364 2.9171839264116786 1.2201519782198902 0.3219991979242683 0.0186204726532014 1.0 0.0412617301526311 0.1927267877862009 0.0208773841861115 +Carbohydrate derivative transmembrane transporter activity 9 10 2.823625704440251 0.0047483801523804 4.672330097087379 10.12135922330097 1.0096229459917263 0.2944050311743799 2.686158589641687 1.471354338494036 1.2935479322863277 0.3146313980204608 1.4163650158743628e-05 1.0 1.0 0.0030679298819029 1.7549530446416166e-05 +Macromolecule transmembrane transporter activity 10 13 2.799952677759093 0.0051110098643034 4.820388349514563 12.281553398058252 1.6605285757306012 0.1306403746261988 2.4754663863133306 1.0160601209961664 1.3599823000893485 0.2280235038874096 0.0017589920567973 0.0001122733832082 0.0008461128461095 0.0011116174795585 0.0002404079656842 +Oxidoreduction driven active transmembrane transporter activity 16 29 2.780762224957072 0.0054231441834289 9.733009708737864 29.83252427184466 0.7626445826297276 0.3795490924215395 4.629116134249794 3.4519743101246267 1.4198222355288384 0.35536187545778 0.0001048875448068 0.0356328568827733 0.0210654976313926 0.0034031169940907 0.0001361709072901 +Sterol binding 8 19 2.778932204038443 0.0054537906384244 5.495145631067961 16.27912621359223 1.1610523788441311 0.1592175050218891 2.159304933149918 1.9111962434971217 1.7231989277496158 0.231586711794193 2.6443864317915908e-05 0.0006661905409434 0.0047474932262074 0.0001800854494167 3.3367197281380665e-05 +Cholesterol binding 8 17 2.7476653553141115 0.0060021235021798 5.25 13.29126213592233 1.1679703080780182 0.1357521674166823 1.9454015982929531 1.7674569958716484 1.7544522374432017 0.2116991383290636 5.143168843515356e-06 0.0003865639533612 0.0028129637769054 6.184484746355669e-05 6.539043847748048e-06 +Quaternary ammonium group binding 3 12 2.7190447160446007 0.0065470756618413 2.8567961165048543 12.12864077669903 0.9707568143407772 0.2573327609820879 1.4849985868988949 1.260087490061347 1.304146106648176 0.2795917987269193 0.0167170186699105 0.0049155620827658 0.0182841548675732 0.0016169545741865 0.0184399659986801 +Protein transmembrane transporter activity 9 12 2.697761389946419 0.0069807456730086 4.37621359223301 11.264563106796116 1.6409152716253632 0.1284874270119089 2.3258190399954897 0.995332092405782 1.387057072324357 0.2266762256512647 0.0007871030357739 6.765318543664244e-05 0.0005152543640852 0.0005775014694085 8.66881295473223e-05 +Monooxygenase activity 6 8 2.685246382644569 0.0072476356758106 4.043689320388349 8.322815533980583 1.6049222537693364 0.1501440468766332 1.612461779657682 1.2307404965531048 1.237349324058907 0.2369071661653372 0.0001657271961217 0.0073558029266518 0.0269433955752302 3.2726981844980405e-05 0.0001989050191546 +Purine nucleotide transmembrane transporter activity 8 9 2.6338586940780546 0.0084420613495574 4.334951456310679 9.441747572815531 0.9917737457277228 0.2833655940290197 2.4104227054611673 1.6217588601139772 1.262135146193827 0.3001583617421954 3.319891610666072e-06 1.0 1.0 0.0004499506622467 4.038707593445951e-06 +Ceramide binding 4 5 2.613384355550444 0.0089650417849196 2.8228155339805827 5.048543689320389 1.42330045764979 0.1242195400491618 1.17628831869178 0.9309003969609838 1.481980135982154 0.2133994029014766 0.0001907872283095 2.8841975049086312e-05 0.0002227826640135 7.961542139625436e-06 0.0002190726437552 +Molecular carrier activity 13 35 2.603757207114425 0.0092208051472215 8.985436893203884 32.922330097087375 0.4263347027610819 0.5995318029338973 4.267144921372851 3.1428430650945036 0.9199841946557948 0.3455794463799358 0.0002371361691019 1.0 0.0168596271371444 0.0459551502585406 0.0003004910826729 +Fad binding 6 10 2.591712593803923 0.0095499516330623 3.78883495145631 9.932038834951456 1.575439945642976 0.1698004033102896 1.8828741719818296 1.250336932628077 0.9196006746446306 0.2289411404885479 0.0009614964859456 1.0 0.2202973788945578 0.0229561163581105 0.0011208161058784 +Electron transfer activity 14 50 2.578371330313272 0.0099267261256061 14.919902912621358 52.12621359223301 0.5312195787834075 0.4459804256520286 6.65997259318913 4.498499451328372 1.405540355221493 0.3721784721862224 4.805909081633214e-05 0.0121710399778658 0.015064113554267 0.0005989342875991 6.71908161905798e-05 +Phosphatidylcholine binding 2 8 2.5691164014085723 0.0101958203295648 2.2524271844660193 7.929611650485437 1.2697801287388335 0.1567893034984199 1.081337239384838 1.04388968498945 1.4953842980517238 0.2256102823610289 0.0346431338005326 0.0026008925831016 0.0098557770733155 0.0058828678879826 0.0373405153007746 +Antiporter activity 7 10 2.566545387155968 0.0102717181667213 4.621359223300971 10.405339805825244 1.056576117278179 0.2813324268221227 2.679901841610502 1.304685592846984 1.2558310293487471 0.3063102364368053 0.0082248074208676 0.1715759324473242 0.3116816529125438 0.0132790770586149 0.0094438169248131 +Sphingolipid binding 4 7 2.5609383340958995 0.0104389883456028 3.2305825242718447 6.810679611650485 1.3881601090528384 0.1287371848492678 1.3662849673921555 1.293404675510669 1.5116584105270494 0.2146285912590262 0.0010490281052016 8.090961716756818e-05 0.0006140521777265 4.808542268366563e-05 0.001197576749496 +Alcohol binding 8 20 2.520198620131356 0.0117288630524357 5.70873786407767 16.094660194174757 1.0972550148478282 0.1642412137618775 2.3364194162363723 2.1334758164294443 1.72577974721897 0.2306417307890987 0.0003967612829955 0.0017444833819259 0.0118439766153993 0.0011138491071993 0.0004919691583091 +Sulfur compound transmembrane transporter activity 5 7 2.518453119196298 0.0117871573787375 2.9635922330097086 6.752427184466019 1.4746434057995097 0.1672652154050841 1.7026919602194592 1.5538455059459366 1.0954441166028872 0.2266277553273111 0.001764656118099 0.0084566179175882 0.0307863463383066 0.004610467719412 0.0020498103930161 +Transition metal ion transmembrane transporter activity 5 6 2.5163277324394 0.0118584855559715 2.2597087378640777 4.444174757281553 1.267846808399692 0.205487024774009 1.5353529408674886 1.9618423203326616 1.2931295194130703 0.2516620757205828 0.0006078389490958 0.0058373227860703 0.0215793786244467 0.0002123083759959 0.0007102363863619 +Anion channel activity 8 12 2.50552891447776 0.0122268400814655 4.20873786407767 11.21116504854369 1.03959259790327 0.2192420598609839 2.3076742714116403 2.0905640066649145 1.3937691950814175 0.2662450395835827 2.5975964900173915e-05 0.0003140311505353 0.0023011729003655 0.0004543195586384 3.2105461874578966e-05 +Protein carrier chaperone 7 11 2.49095721738879 0.0127399459417985 3.3980582524271843 10.118932038834952 0.8288787693114796 0.3398938251553178 1.8569721980092944 2.0920401213092656 1.1849901066971258 0.3127406939001886 0.0001060978552471 1.0 0.0006140521777265 0.0082779259052177 0.0001248620251216 +Endopeptidase activity 24 61 2.464434503561082 0.013722964152296 19.08495145631068 62.800970873786405 1.5604938505680932 0.2935756148549138 5.629332570724372 6.156865220927466 1.27979578418692 0.359984229645684 0.0006151412828744 1.0 0.4707704242707984 0.1002867691628247 0.0008657243187944 +Hydrolase activity hydrolyzing o glycosyl compounds 9 22 2.456413194381012 0.0140331700813813 8.830097087378642 20.84223300970874 0.5983257656540719 0.2104301479001341 3.2223833352824554 2.4557961681485057 1.9540573665272416 0.2728112677124137 5.206826791484075e-05 0.2068720246529641 0.3686542667111886 0.1050127227394893 6.673062892762862e-05 +Symporter activity 8 10 2.443046360182938 0.0145638662902007 3.638349514563106 9.1747572815534 0.9770544165414302 0.3122690599192905 2.3735568316725377 2.065327188945721 1.1044541290009051 0.3081067804681572 0.0146811150751496 1.0 0.3439334989552355 0.0199990348372571 0.016761518835176 +Oxidoreductase activity acting on other nitrogenous compounds as donors 0 5 2.4002181929303488 0.0163853017512349 0.9053398058252428 4.968446601941747 0.7298979816211466 0.356591048806678 1.1939453367119757 0.8074137752294054 0.9976202195593978 0.2661615032217306 0.2808814761473663 0.0331691185540615 0.0647424502180396 0.1548127998356016 0.2880976379428142 +Hexosyltransferase activity 11 34 2.3993907599404265 0.0164223790965831 9.633495145631068 33.87864077669903 0.7349501031127185 0.3949358882560483 4.261380470236419 4.330948695045228 1.2646745007039175 0.3422146027467064 0.0060817124787681 0.4243503559946278 0.295605483028919 0.0056900283119864 0.0076270649764927 +Glycolipid binding 6 10 2.3958377512281395 0.0165824287552722 3.95873786407767 9.17233009708738 1.1300394975336625 0.1723818604496332 1.779261971800237 1.789101691327159 1.517965150696512 0.2390589148665743 5.421083652472187e-06 0.0029386578360865 0.0111011801010317 1.6702585542338638e-06 6.586690043237225e-06 +Gated channel activity 8 14 2.3782200919906096 0.0173964389654115 4.317961165048544 13.019417475728156 0.8697524591818097 0.2583579989367679 2.2914716766946497 2.0107989163575497 1.3733766112751231 0.2762671399351702 0.0195828489175404 0.0029449884503582 0.0193203782926452 0.0136728919383771 0.0226061192548448 +Atp transmembrane transporter activity 5 6 2.370322771184615 0.0177725623066076 3.058252427184466 5.456310679611651 0.5680189081478334 0.3318090311699867 1.598392655736251 0.6936144116307477 1.3025695117924114 0.3140848719976767 1.0062291998605608e-05 1.0 1.0 0.0142938954224823 1.1622264404762372e-05 +Membrane insertase activity 5 8 2.3554695734470905 0.0184993119684424 2.737864077669903 7.388349514563107 0.8099367695235317 0.306513025583228 1.5809003521008822 1.7333564146948666 1.2685525479217892 0.3048480656363501 0.0002856166640566 1.0 0.0002815881021324 0.0039601236721776 0.0003275783690493 +Vitamin transmembrane transporter activity 5 6 2.321595357848815 0.0202547340945262 2.7766990291262137 6.252427184466019 1.4438342367310928 0.182339474606115 1.52603324115363 1.3650879028699858 1.0282691527982806 0.2346378729908682 0.0013704364806795 0.0036723611473879 0.0137871179019738 0.0736296228832766 0.0015626966448138 +Calcium ion binding 25 81 2.3202916014905206 0.0203251081400299 21.00485436893204 81.67961165048544 0.6464856503310022 0.4940276647939897 7.408010340962093 8.52860815905726 1.2261945166831902 0.3858741960292539 0.0168538625628935 0.3860509975104039 0.7450556624969219 0.0659936387755623 0.0121855505106736 +Metalloendopeptidase activity 7 14 2.242886388330128 0.0249041417360733 5.449029126213592 14.364077669902912 1.4597326207035937 0.2246869419023046 2.4848715129851016 0.6671711573432166 0.9390012824303952 0.2775881383017788 0.016487126438091 1.0 0.2709026461704186 0.5479465724917809 0.0185058115778357 +Nadh dehydrogenase activity 10 23 2.1987944863207143 0.0278925387390867 6.62621359223301 21.9004854368932 0.6460127731992702 0.4045936795236815 3.355345283841267 2.6889381015310834 1.101850132292176 0.306596625090648 0.0001188800566425 0.187449079081247 0.0628860756551618 0.0185163109854147 0.0001486944326884 +Voltage gated anion channel activity 6 7 2.192345454754953 0.0283545719501414 2.854368932038835 6.25 1.127126362633441 0.1649553590552043 1.5417035527207152 0.9966570336472054 1.4583344406160936 0.2334940994157564 4.192166113989691e-05 0.0009934566258862 0.0038356556834428 0.0014005858473499 4.83066106284651e-05 +L amino acid transmembrane transporter activity 5 7 2.1919408634546658 0.0283837769604597 3.628640776699029 8.201456310679612 0.919975936290114 0.2876791162304417 2.2759730869054327 1.0290432051153906 1.15482978403653 0.2925518180165951 0.3880483273714945 1.0 0.2423974925429197 0.5022110525395543 0.4023818247040491 +Iron ion binding 8 18 2.1842799721540183 0.0289416815289289 6.524271844660194 22.196601941747577 0.9076096695164306 0.382669917893863 2.4429198675966717 3.289094676807881 0.9378690899634522 0.3126784916965753 0.0212769263765699 0.2552681350600493 0.4428019399824193 0.176085331764227 0.0245338715183181 +Dicarboxylic acid transmembrane transporter activity 7 8 2.183216261430752 0.0290198877863516 2.842233009708738 7.20873786407767 1.0708946030323223 0.2426579907451208 1.9772646753006824 0.7975212565102757 1.0844681659651012 0.2564515003952125 0.0346431338005326 0.0742352733278267 0.1419203898220533 0.0541048590842698 0.0373405153007746 +Abc type transporter activity 5 6 2.159741652830357 0.0307926747623203 3.0194174757281553 7.652912621359223 0.9831250219385844 0.2361571806590424 1.9482657586917436 2.350049836723345 1.2743804993059251 0.258194993176919 0.0049865165510375 1.0 1.0 0.1179126451543179 0.0056472897550706 +Solute cation symporter activity 4 8 2.1397314899597366 0.0323764726475663 2.854368932038835 7.206310679611651 0.8639239563858236 0.3319920905256767 1.9640347167867271 2.0653542869596597 1.117186698589392 0.3146562336443082 0.016487126438091 1.0 0.2709026461704186 0.0427102581002517 0.0185058115778357 +Adp transmembrane transporter activity 4 5 2.13688846590094 0.0326070643543841 2.3689320388349513 4.201456310679611 0.5019942413211786 0.3489879061320977 1.2147179245232118 0.4188493432764195 1.248361495348926 0.3086395860172816 2.130491764661308e-05 1.0 1.0 0.0053511077329156 2.3946565882449505e-05 +Peptide antigen binding 4 6 2.123823722376066 0.0336848865678331 2.25 5.218446601941747 1.3488418251083294 0.2076946662826 1.4985834735457568 1.269832767279765 0.9581301458127084 0.2397273125927817 0.0291172285701084 1.0 0.1336663515258769 0.048077110185513 0.0314157626389551 +Amino acid transmembrane transporter activity 7 10 2.114577453243265 0.0344659769969886 4.325242718446602 10.521844660194176 0.9562493229862624 0.2921494362491497 2.574340086864074 1.34633933573134 1.106576767449958 0.2884960270895668 0.2789043518042891 1.0 0.3182551371737898 0.6181414355057374 0.2940561328219075 +Hydrolase activity acting on glycosyl bonds 10 31 2.1017502715511416 0.0355751573414424 10.133495145631068 28.40776699029126 0.6089784953463463 0.2409908190925149 3.36301188653944 3.2424277527979313 1.935823411407979 0.3010513017078077 0.0004654526991316 0.297366720714231 0.5035637282775228 0.2502626974688664 0.0005959516742334 +Serine type carboxypeptidase activity 3 5 2.093164895198411 0.0363344372846623 3.0558252427184467 4.997572815533981 1.0019911760482532 0.1105835516254352 1.1231414198895626 0.0492066381861973 1.8086551291944464 0.1930654928989846 0.0009022029341388 0.0238038053541035 0.0466801529674521 0.0053511077329156 0.0009835199259377 +Amide transmembrane transporter activity 4 5 2.089177392741901 0.0366917576882956 1.9781553398058251 4.745145631067961 1.408683964326367 0.195466717632665 1.3391087077639925 1.811666809674734 1.0002201259794938 0.2223338014085611 0.0119032172051617 0.0919337377678228 0.1741653971767485 0.0111687214620054 0.0131582573898405 +C4 dicarboxylate transmembrane transporter activity 5 6 2.051740575811086 0.0401948811542443 2.5800970873786406 5.762135922330097 0.7175594553016044 0.3314419534241876 1.791536735339018 0.4257754786552994 1.1176795047305017 0.2969876515759702 0.0882392114562766 0.0516364610584135 0.0998570540504815 0.2323046488407439 0.0928255051702242 +Quinone binding 1 5 2.049746795203414 0.0403891459713154 2.0825242718446604 5.371359223300971 0.6144040024425256 0.3400691378536611 1.308295206174148 0.7946759106689059 1.1785397932704846 0.300626350021166 0.1178918559077091 0.0607401038440192 0.1169218221283287 0.0368360647660487 0.123804083941321 +Voltage gated channel activity 7 11 2.043942913525055 0.0409591870480634 3.2257281553398056 10.116504854368932 0.8578192560085278 0.2690365421745596 1.8168622808181427 1.411127559025233 1.234834479111217 0.2694186191218866 0.0186204726532014 0.0115082778780227 0.0412617301526311 0.0460491564663638 0.0208773841861115 +O acyltransferase activity 6 15 2.0325260700210364 0.0421004273125849 4.711165048543689 12.395631067961164 0.9877600518928406 0.2684789023147002 2.6842893514436073 2.3496085895491885 1.2379749168209273 0.2720543739153138 0.0145226792138712 1.0 1.0 0.0394981797992919 0.0163188417867018 +Acylglycerol o acyltransferase activity 4 8 2.013456056192215 0.0440666734868591 2.6601941747572817 6.820388349514563 0.8174935736497821 0.2734948556707107 1.708365471336677 1.514259678343348 1.2372108727630755 0.2654117957889352 0.0695538775916506 1.0 1.0 0.0877027952007016 0.0746022325302512 +P type transmembrane transporter activity 3 5 1.9871446278609728 0.0469063719352129 2.842233009708738 5.473300970873787 0.6050493013674468 0.3730987003611934 1.6045635356324264 1.3712604140019378 1.17652933932801 0.3174788438558891 0.0155926449404773 1.0 1.0 1.0 0.0168746974098865 +Glucosyltransferase activity 1 8 1.9806019704904183 0.047635927794936 2.342233009708738 9.048543689320388 0.4761205412145978 0.5159240070556952 1.9500716601415085 1.525693480881991 0.8525181118658677 0.3136461905246437 0.199660478430383 0.083126337411673 0.0124120710913681 0.0668959947775429 0.2087954316884295 diff --git a/msigdb_gomf/metrics.json b/msigdb_gomf/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..8669e5e6cf1862a7f53bcdf4ba726fbd2af82fc9 --- /dev/null +++ b/msigdb_gomf/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2974, + "annotations_size": 1350, + "title": "Average number of proteins per term", + "value": 15.713333333333333 +} \ No newline at end of file diff --git a/msigdb_gomf/paths.json b/msigdb_gomf/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..9bffe6548325d7ecab61277f0e080a5c84a898a9 --- /dev/null +++ b/msigdb_gomf/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/msigdb_gomf/fragment/C220/C220_val_log2fc"} \ No newline at end of file diff --git a/msigdb_gomf/result.tsv b/msigdb_gomf/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..ff18ef782129930c51dba716f02656d1579850ba --- /dev/null +++ b/msigdb_gomf/result.tsv @@ -0,0 +1,367 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Cation transmembrane transporter activity 0.6781840413324405 5.187415822532523 2.1323225603801374e-07 0.0002878221475996 0.0001439317728263 71 Q9HC21,O00400,Q8IUH4,P13073,P35670,Q9H0U3,P00403,Q70HW3,P05023,Q13423,Q9UDW1,O75964,P51790,Q9H2J7,P05141,P20020,P00846,Q6NXT4,Q9HD20,Q9HC07,Q96NB2,Q00325,Q9H936,Q8TAD4,Q6P4Q7,P61421,P24539,Q9Y487,P16615,Q96ES6,Q9Y619,Q93050,Q9UM00,Q4KMQ2,O95202,Q15043,P56385,Q86VD7,Q9NW15,P08574,O43808,Q15758,P12235 43 +Inorganic molecular entity transmembrane transporter activity 0.671850013241595 5.07483708422482 3.878281405274122e-07 0.0005234310533847 0.0001745226632377 77 Q8IUH4,O00400,P13073,Q9C0H2,P35670,Q9H0U3,P00403,Q9Y277,P05023,Q9UBX3,P45880,Q13423,Q9UDW1,O75964,P51790,P05141,Q9H2J7,P20020,O43681,P21796,P00846,Q6NXT4,Q9HD20,Q9HC07,Q00325,Q9H936,Q8TAD4,Q6P4Q7,P33527,P24539,Q9Y487,P16615,P51798,Q96ES6,Q93050,O95202,Q4KMQ2,Q15043,P56385,Q9NW15,P08574,Q99797,P12235,Q96S66 44 +Active transmembrane transporter activity 0.6583311034516802 4.999695167553645 5.742102355397003e-07 0.0007748836630118 0.0001937959544949 71 O00400,P13073,P35670,P41440,P00403,P05023,Q9UBX3,O96000,Q9UDW1,Q03518,P51790,Q9H2J7,P05141,P20020,O95139,P31930,O43676,Q9HD20,P51970,Q9Y6M9,Q00325,O75438,Q9H936,O00483,P61421,P33527,P08183,Q02978,P53985,Q9P0J0,P16615,P12236,Q9Y6M7,P51798,O43674,Q96ES6,P20674,O75027,P03886,Q15388,O95202,Q15043,P08574,O95168,Q15758,P12235,P28288,P53007 48 +Ion transmembrane transporter activity 0.6745722586996298 4.900206355685737 9.57360475083436e-07 0.0012916024226897 0.0002584873282727 101 Q9BVC6,Q8IUH4,O00400,Q9HC21,P13073,Q9UJS0,Q9C0H2,P35670,P41440,Q9H0U3,P00403,Q70HW3,Q9Y277,P05023,Q9UBX3,P45880,Q13423,Q9UDW1,O75964,P51790,P05141,Q9H2J7,P20020,O43681,P21796,P00846,Q6NXT4,Q96NB2,Q9HC07,Q9H2D1,Q9HD20,Q00325,Q9H936,Q8TAD4,P61421,Q6P4Q7,P33527,Q9BQT8,P24539,P53985,Q9Y487,P16615,P12236,P51798,Q96ES6,Q9Y619,O75746,Q93050,Q9UM00,O95202,Q4KMQ2,Q15043,P56385,Q9NW15,Q86VD7,Q8TB61,Q6NUK1,P08574,O43808,Q15758,P12235,Q96S66,Q6P4A7,P53007 64 +Anion transmembrane transporter activity 0.6984605788682997 4.316372376089839 1.5861431728048103e-05 0.0211854698419719 0.003568822138811 45 Q9HC21,O00400,Q9UJS0,Q9C0H2,P41440,Q9Y277,Q9UBX3,P45880,P51790,P05141,O43681,P21796,Q96NB2,Q9H2D1,Q9H936,P33527,Q9BQT8,P53985,P12236,P51798,Q9Y619,O75746,Q4KMQ2,Q15043,Q86VD7,Q9NW15,Q6NUK1,Q8TB61,O43808,Q15758,P12235,Q9H9B4,Q96S66,P53007 34 +Active ion transmembrane transporter activity 0.7122225313296651 4.242596292463259 2.2094868808997248e-05 0.0293879260585177 0.0042611532703068 40 O00400,P13073,P35670,P41440,P00403,P05023,Q9UDW1,P51790,Q9H2J7,P05141,P20020,P31930,Q9HD20,Q00325,Q9H936,P61421,P33527,Q02978,P16615,P12236,Q9Y6M7,P51798,Q96ES6,P20674,O95202,Q15043,P08574,P12235,P53007 29 +Transporter activity 0.6577551622322027 4.2112576572266915 2.539528927725243e-05 0.0337030359902726 0.0042854550655365 176 Q9BVC6,Q99595,O60830,Q9C0H2,P51991,P41440,Q70HW3,Q8IXU6,Q9UBX3,P45880,Q9UDW1,O75964,P51790,Q9NS69,P20020,P21796,P00846,P04062,Q9NV96,O43676,Q6NXT4,P51970,Q9HC07,Q96NB2,Q8NBU5,Q9H2D1,Q9H936,P49755,P61421,O15173,P60059,O43674,Q96ES6,Q9Y619,O75746,P03886,Q93050,Q9BSK2,Q9UM00,Q07820,Q15758,P12235,Q9H9B4,Q8IUH4,O00400,P13073,O14925,Q14849,Q9Y277,Q13423,Q03518,Q9HD20,O75438,P17900,Q8TAD4,Q9BQT8,P24539,P53985,Q9P0J0,P12236,O15118,O95202,Q15043,Q9NW15,Q8TB61,Q99797,Q9Y5J6,Q8WTV0,Q9HC21,Q9UJS0,Q96AA3,P00403,P05023,O96000,P05141,Q9H2J7,O95139,Q9Y6M9,Q7L0J3,L0R6Q1,Q00325,P38435,P33527,Q9Y487,P16615,O75027,Q8NE01,Q4KMQ2,Q86VD7,Q6NUK1,O95168,Q96S66,P35670,Q9H0U3,Q9Y5J9,O96008,O43681,P30536,Q6P4Q7,P08183,P51798,Q15388,P56385,P08574,O43808,Q6P4A7,P53007 107 +Organic anion transmembrane transporter activity 0.7220297391493762 3.939938992171909 8.150233298964693e-05 0.104195098479088 0.0122253499484471 29 Q9HC21,O00400,Q9UJS0,P41440,Q9UBX3,P05141,Q96NB2,Q9H2D1,Q9H936,P33527,Q9BQT8,P53985,P12236,Q9Y619,O75746,Q86VD7,Q8TB61,Q6NUK1,O43808,Q15758,P12235,P53007 22 +Proton transmembrane transporter activity 0.6847817201730737 3.8905810409247423 0.0001000044699694 0.126295259146152 0.0135006034458819 35 O00400,P13073,P00403,Q13423,Q9UDW1,O75964,P51790,P05141,P00846,Q00325,Q9H936,P24539,Q9Y487,Q96ES6,Q93050,O95202,P56385,P08574,P12235 19 +Secondary active transmembrane transporter activity 0.754956871762428 3.7870986649289464 0.0001524165893571 0.185986296233216 0.0187056723301973 22 Q9H2J7,O00400,P53985,O95202,Q15043,P51790,P12236,Q00325,Q9H936,P41440,Q02978,P51798,Q15758,Q96ES6,P12235,Q9UBX3,P53007,P05141 18 +Primary active transmembrane transporter activity 0.6022444442011448 3.708924974828654 0.0002081410849581 0.2449865471760441 0.0234158720577916 50 P13073,P35670,P00403,P05023,O96000,Q9UDW1,Q03518,P20020,O95139,P31930,O43676,Q9HD20,P51970,Q9Y6M9,O75438,O00483,P61421,P33527,P08183,Q9P0J0,P16615,P51798,O43674,P20674,O75027,P03886,Q15388,P08574,O95168,P28288 30 +Steroid binding 0.7036945291794743 3.540323590276249 0.0003996367065692 0.4170287376224202 0.0415007349129642 24 P35610,P21796,O15173,P04062,O15118,Q14108,Q14849,O95772,P38435,P05023,P45880,O00264,O75477 13 +Tetrapyrrole binding 0.7846728443542446 3.456934219587486 0.0005463581987998 0.5218281700557699 0.0526845405985609 17 O43169,O15173,P09601,Q9H7Z7,P08574,P30519,Q6UW02,P53701,Q16850,Q8WUJ1,O00264 11 +Organic acid transmembrane transporter activity 0.7066251252950247 3.431095836138075 0.0006011481821615 0.555939326846238 0.0541033363945354 21 Q9H2J7,P08183,Q9BQT8,P53985,Q9UJS0,Q96NB2,Q9H2D1,Q9H936,P41440,Q15758,Q9UBX3,Q9Y619,P53007,O75746,P33527 15 +Nucleobase containing compound transmembrane transporter activity 0.8256756756756809 3.3424206243414916 0.0008305110452995 0.6742599959479811 0.0700743694471471 14 Q9BSK2,Q9HC21,O00400,P51991,L0R6Q1,Q6NUK1,Q8TB61,P12236,Q9H2D1,Q86VD7,O43808,P12235,P05141 13 +Metal ion transmembrane transporter activity 0.6546262551488395 3.292791526239319 0.0009919799853099 0.7381118136976882 0.0787748811863805 26 Q9H2J7,Q8IUH4,P20020,O95202,Q9HD20,Q6NXT4,Q9HC07,P16615,Q15043,P35670,Q9H0U3,P05023,Q8TAD4,Q6P4Q7 14 +Atpase coupled transmembrane transporter activity 0.6654288744022735 3.155216310483627 0.0016037915100726 0.8854629120871742 0.1050609586564719 21 P08183,P20020,Q15388,Q9HD20,P16615,P35670,P51798,P05023,O75027,P61421,Q03518,P33527 12 +Protein transporter activity 0.7517512340795882 3.145459447662871 0.0016582618246097 0.8935959516653774 0.1050609586564719 16 Q99595,Q15388,Q9NS69,O60830,P60059,Q8NBU5,Q9HD20,O14925,Q07820,Q9Y5J9,Q9Y5J6,P49755,O96008 13 +Nucleotide transmembrane transporter activity 0.8251181634031136 3.126682943252616 0.0017679047284293 0.908258787848218 0.1050609586564719 12 Q9BSK2,Q9HC21,O00400,Q9H2D1,P12236,Q8TB61,Q6NUK1,Q86VD7,O43808,P12235,P05141 11 +Organophosphate ester transmembrane transporter activity 0.8251181634031136 3.126682943252616 0.0017679047284293 0.908258787848218 0.1050609586564719 12 Q9BSK2,Q9HC21,O00400,Q9H2D1,P12236,Q8TB61,Q6NUK1,Q86VD7,O43808,P12235,P05141 11 +Inorganic anion transmembrane transporter activity 0.6659298390903936 3.1230411106750844 0.0017899274437769 0.9109508865846722 0.1050609586564719 20 O43681,P21796,P33527,Q4KMQ2,Q9C0H2,Q15043,Q9NW15,P0CG08,Q02978,P51798,Q9Y277,Q96S66,Q9UBX3,P45880,P51790 15 +Passive transmembrane transporter activity 0.5798755899950777 3.058719162283278 0.0022228542196036 0.9504212704427422 0.1154174306332672 35 Q9BVC6,P24539,P21796,P00846,Q4KMQ2,Q9C0H2,P56385,Q9NW15,Q99797,P51798,Q9Y277,Q96S66,P45880,O96008,O75964 15 +Serine hydrolase activity 0.6722966302701716 3.0248392403748494 0.0024876531461139 0.9653520206152204 0.1243826573056994 19 Q9H3G5,P42785,Q5JRX3,O14773,P10619,Q6NTF9,Q16740,P67812,Q9HB40,O43464,Q4J6C6 11 +Oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen 0.6229545449853404 2.973599978606328 0.0029432850384734 0.9813011597691822 0.1381496988285449 24 O00767,Q15800,P16435,O15121,P09601,O95864,P30519,Q6UW02,Q9BU89,Q14534,P13674,Q16850 12 +Molecular transducer activity 0.5590515591259779 2.866041218096486 0.0041564012487154 0.996385620836278 0.148387451872701 34 O75787,O15173,O15118,Q14108,Q8WU17,P30536,Q9UGP8,Q99442,P49327,Q9NRA0,Q15758,Q8WTV0,Q15629,Q99720,Q08722,P22466,Q9Y6I9,Q9BUN8 18 +Snap receptor activity 0.7334353579290528 2.833104242883719 0.0046098350324135 0.9980455875549348 0.148387451872701 14 Q12846,Q9P2W9,O15400,Q86Y82,Q13190,Q12981,O60499,O15498,O95249,Q9UNK0 10 +Carbohydrate derivative transmembrane transporter activity 0.8245614035087795 2.823625704440251 0.0047483801523804 0.9983804077484016 0.148387451872701 10 O00400,Q86VD7,L0R6Q1,Q6NUK1,Q8TB61,P12236,O43808,P12235,P05141 9 +Macromolecule transmembrane transporter activity 0.7456932722676349 2.799952677759093 0.0051110098643034 0.9990097531110774 0.148387451872701 13 Q99595,Q15388,Q9NS69,O60830,P60059,O14925,P51991,Q07820,P49755,O96008 10 +Oxidoreduction driven active transmembrane transporter activity 0.5675322612679562 2.780762224957072 0.0054231441834289 0.9993517076443944 0.148387451872701 29 O95139,P13073,P31930,O43676,Q9Y6M9,P51970,Q9P0J0,O75438,P08574,O00483,P00403,O43674,O95168,O96000,Q9UDW1,P03886 16 +Sterol binding 0.6353989195795481 2.778932204038443 0.0054537906384244 0.9993781226965842 0.148387451872701 19 P35610,P21796,O15118,Q14108,Q14849,O95772,P45880,O75477 8 +Cholesterol binding 0.6676446117426144 2.7476653553141115 0.0060021235021798 0.999704629977697 0.1498834078292244 17 P35610,P21796,O15118,Q14108,Q14849,O95772,P45880,O75477 8 +Quaternary ammonium group binding 0.7480210222548357 2.7190447160446007 0.0065470756618413 0.9998591214501704 0.155062318306768 12 Q14108,P45880,P21796 3 +Protein transmembrane transporter activity 0.7441013656641634 2.697761389946419 0.0069807456730086 0.9999218635453552 0.1624828734234774 12 Q99595,Q15388,Q9NS69,O60830,P60059,O14925,Q07820,P49755,O96008 9 +Monooxygenase activity 0.8728582339804579 2.685246382644569 0.0072476356758106 0.9999456429896212 0.1630718027057398 8 Q15800,P09601,P30519,Q6UW02,Q14534,Q16850 6 +Purine nucleotide transmembrane transporter activity 0.8242833052276496 2.6338586940780546 0.0084420613495574 0.9999892988726384 0.1677291007340291 9 O00400,Q86VD7,P12236,Q6NUK1,Q8TB61,O43808,P12235,P05141 8 +Ceramide binding 0.9447625463118894 2.6133843555504437 0.0089650417849196 0.9999947505325796 0.1686625912812255 5 P45880,P21796,Q9UM22,P07602 4 +Molecular carrier activity 0.5265258666323284 2.603757207114425 0.0092208051472215 0.9999962950207176 0.1686625912812255 35 Q9NPA0,O00505,Q96P70,Q9Y5J7,Q92973,O75880,Q53FT3,P40855,Q5J8M3,Q8N8Q8,O43819,P52292,Q15070 13 +Fad binding 0.7781068793108122 2.591712593803923 0.0095499516330623 0.9999976341910274 0.1686625912812255 10 O95831,O15254,Q15067,Q14534,O00116,Q15392 6 +Electron transfer activity 0.4838027889820198 2.5783713303132716 0.0099267261256061 0.9999985845147886 0.1686625912812255 50 O95139,P13073,P14406,Q9Y6M9,O43676,O15121,Q9P0J0,O75438,O95168,P00403,P21912,O96000,Q9UDW1,P03886 14 +Phosphatidylcholine binding 0.8474011516526649 2.5691164014085723 0.0101958203295648 0.9999990193081418 0.1686625912812255 8 P45880,P21796 2 +Antiporter activity 0.7731451511084937 2.566545387155968 0.0102717181667213 0.9999991157526732 0.1686625912812255 10 O95202,P12236,P41440,P51798,P12235,Q9UBX3,P05141 7 +Sphingolipid binding 0.8613846434285509 2.5609383340958995 0.0104389883456028 0.9999992961542667 0.1686625912812255 7 P45880,P21796,Q9UM22,P07602 4 +Alcohol binding 0.5796408633201292 2.520198620131356 0.0117288630524357 0.9999998790096256 0.1740337780363151 20 P35610,P21796,O15118,Q14108,Q14849,O95772,P45880,O75477 8 +Sulfur compound transmembrane transporter activity 0.8519676978959888 2.518453119196298 0.0117871573787375 0.999999888270886 0.1740337780363151 7 Q9HC21,O00400,Q8TB61,Q70HW3,Q9UBX3 5 +Transition metal ion transmembrane transporter activity 0.8669137466307208 2.5163277324394 0.0118584855559715 0.9999998986446964 0.1740337780363151 6 Q9HD20,Q15043,Q6NXT4,Q9HC07,Q8TAD4 5 +Anion channel activity 0.7091580982752704 2.5055289144777597 0.0122268400814655 0.9999999387298956 0.1740337780363151 12 P21796,Q4KMQ2,Q9C0H2,Q9NW15,P51798,Q9Y277,Q96S66,P45880 8 +Protein carrier chaperone 0.721425844684092 2.49095721738879 0.0127399459417985 0.9999999696182336 0.1751130300049413 11 Q9NPA0,Q9Y5J7,Q5J8M3,Q15006,Q8N8Q8,P40855,Q15070 7 +Endopeptidase activity 0.4303403190478184 2.464434503561082 0.013722964152296 0.9999999920833086 0.1754146260172673 61 Q5JRX3,O43292,Q99538,Q16740,O43464,P36776,Q10713,P07858,Q92643,Q9BXS4,P49721,P42892,O14773,O75844,P28070,Q9NZ08,Q6NTF9,P28072,Q92542,P67812,Q13043,Q99797,P22695,Q4J6C6 24 +Hydrolase activity hydrolyzing o glycosyl compounds 0.562750594707081 2.456413194381012 0.0140331700813813 0.9999999948226066 0.1754146260172673 22 P17050,P04062,P54802,P17900,P06280,P10253,Q9BTY2,Q9NUJ1,P16278 9 +Symporter activity 0.7490173583200782 2.443046360182938 0.0145638662902007 0.999999997497052 0.1757346984597405 10 Q9H2J7,P53985,O00400,Q15043,Q00325,Q9H936,Q15758,Q96ES6 8 +Hexosyltransferase activity 0.5050970674826525 2.3993907599404265 0.0164223790965831 0.9999999998042678 0.1757346984597405 34 P46977,P04062,Q8N4A0,Q6ZXV5,Q10472,Q9BV10,Q13126,Q9BT22,Q16739,Q2TAA5,O43505 11 +Glycolipid binding 0.7398895238221515 2.3958377512281395 0.0165824287552722 0.9999999998428728 0.1757346984597405 10 O14773,Q9H490,Q9NZJ7,Q9UM22,P07602,P50897 6 +Gated channel activity 0.6557607008188069 2.3782200919906096 0.0173964389654115 0.9999999999486252 0.1777256230660762 14 Q9BVC6,P21796,Q4KMQ2,Q9C0H2,Q9NW15,P51798,Q9Y277,P45880 8 +Atp transmembrane transporter activity 0.8342318059299143 2.370322771184615 0.0177725623066076 0.9999999999693604 0.1777256230660762 6 Q86VD7,P12236,Q6NUK1,P12235,P05141 5 +Membrane insertase activity 0.8015012761124062 2.3554695734470905 0.0184993119684424 0.9999999999887196 0.1814457322654266 8 Q9NPA0,Q9Y5J7,Q5J8M3,Q8N8Q8,Q15070 5 +Vitamin transmembrane transporter activity 0.82345013477088 2.321595357848815 0.0202547340945262 0.9999999999989936 0.1830179760948684 6 Q9HC21,P04062,Q9H2D1,P38435,P33527 5 +Calcium ion binding 0.4202358453882959 2.3202916014905206 0.0203251081400299 0.9999999999990866 0.1830179760948684 81 Q9Y680,Q02818,Q9UJS0,Q9UM22,Q96A33,Q9NPF0,P80303,Q13586,O43681,Q8IYU8,P27824,Q9BRK5,O43852,O75071,Q99584,Q96AY3,P16615,P55327,Q8NF37,O95202,Q9NWM8,O95302,Q6NUK1,Q14257,P04083 25 +Metalloendopeptidase activity 0.6334552959740909 2.242886388330128 0.0249041417360733 0.9999999999999984 0.2088235487186275 14 P42892,Q5JRX3,O75844,Q99797,Q10713,Q9BYT8,P22695 7 +Nadh dehydrogenase activity 0.5249776369250669 2.1987944863207143 0.0278925387390867 1.0 0.2240824496878404 23 O95139,Q9Y6M9,O43676,O95831,P51970,Q9P0J0,O75438,O95168,O96000,P03886 10 +Voltage gated anion channel activity 0.7812605325244202 2.1923454547549532 0.0283545719501414 1.0 0.2240824496878404 7 P21796,Q4KMQ2,P51798,Q9Y277,P45880,P51790 6 +L amino acid transmembrane transporter activity 0.7811744811592768 2.1919408634546658 0.0283837769604597 1.0 0.2240824496878404 7 Q9UJS0,Q9H936,Q15758,Q9Y619,O75746 5 +Iron ion binding 0.5662802615132037 2.1842799721540183 0.0289416815289289 1.0 0.2264557717432067 18 O00767,Q9UMS0,Q15800,P22830,P13674,Q6UW02,Q9BU89,Q16850 8 +Dicarboxylic acid transmembrane transporter activity 0.7653405259608747 2.183216261430752 0.0290198877863516 1.0 0.2264557717432067 8 Q9BQT8,Q9UJS0,Q9H936,P41440,Q15758,Q9UBX3,O75746 7 +Abc type transporter activity 0.7880727762803146 2.1597416528303572 0.0307926747623203 1.0 0.2341833192738869 6 P08183,Q9HD20,O75027,Q03518,P33527 5 +Solute cation symporter activity 0.75632640766455 2.1397314899597366 0.0323764726475663 1.0 0.2365326096242066 8 Q9H2J7,O00400,Q96ES6,Q15043 4 +Adp transmembrane transporter activity 0.8339508251936676 2.13688846590094 0.0326070643543841 1.0 0.236664176765691 5 P12235,Q86VD7,P12236,P05141 4 +Peptide antigen binding 0.7803101557128335 2.123823722376066 0.0336848865678331 1.0 0.2395151288552298 6 Q15392,P10321,P04439,Q03518 4 +Amino acid transmembrane transporter activity 0.6865579745660276 2.114577453243265 0.0344659769969886 1.0 0.2401010835676753 10 Q9H2J7,Q9UJS0,Q96NB2,Q9H936,Q15758,Q9Y619,O75746 7 +Hydrolase activity acting on glycosyl bonds 0.4757131839027073 2.1017502715511416 0.0355751573414424 1.0 0.2443844313369757 31 O75503,P17050,P04062,P54802,P17900,P06280,P10253,Q9BTY2,Q9NUJ1,P16278 10 +Serine type carboxypeptidase activity 0.8240715066086621 2.093164895198411 0.0363344372846623 1.0 0.2464899011773576 5 Q9HB40,P42785,P10619 3 +Amide transmembrane transporter activity 0.8231727854496459 2.0891773927419015 0.0366917576882956 1.0 0.2467931060686681 5 O00400,Q9H2D1,Q03518,P33527 4 +C4 dicarboxylate transmembrane transporter activity 0.7648247978436523 2.051740575811086 0.0401948811542443 1.0 0.2646861507828927 6 Q9UJS0,Q9H936,Q15758,Q9UBX3,O75746 5 +Quinone binding 0.8143057287296813 2.049746795203414 0.0403891459713154 1.0 0.2646861507828927 5 Q8N0U8 1 +Voltage gated channel activity 0.6410294316901681 2.043942913525055 0.0409591870480634 1.0 0.2658408774754118 11 Q9BVC6,P21796,Q4KMQ2,P51798,Q9Y277,P45880,P51790 7 +O acyltransferase activity 0.5866140497285941 2.0325260700210364 0.0421004273125849 1.0 0.2698734002439278 15 Q9NUQ2,P35610,Q8NF37,P23786,Q92604,Q96N66 6 +Acylglycerol o acyltransferase activity 0.7304017134366801 2.013456056192215 0.0440666734868591 1.0 0.2779906972301859 8 Q9NUQ2,Q92604,Q8NF37,Q96N66 4 +P type transmembrane transporter activity 0.8003011177704417 1.9871446278609728 0.0469063719352129 1.0 0.2889280965531686 5 P35670,P05023,P16615 3 +Glucosyltransferase activity 0.723716330227588 1.9806019704904183 0.047635927794936 1.0 0.2889280965531686 8 P04062 1 +Wide pore channel activity 0.862289562289575 1.966231617392919 0.0492718618059306 1.0 0.2948903408114275 4 P45880,P21796,Q9Y277 3 +Porin activity 0.862289562289575 1.966231617392919 0.0492718618059306 1.0 0.2948903408114275 4 P45880,P21796,Q9Y277 3 +Palmitoyl protein hydrolase activity 0.7897921273196744 1.9399097784649484 0.0523906554941584 1.0 0.3115743828947748 5 Q9UMR5,P50897 2 +Antigen binding 0.7275663154605893 1.9362469515527612 0.0528374625335765 1.0 0.3128533965803876 7 Q15392,P10321,P04439,Q03518 4 +Exogenous protein binding 0.5801323354134232 1.9106137949253656 0.0560542302640325 1.0 0.3204072920059697 14 P11279,O15118,Q14108,P35613,P02786,Q8WTV0 6 +Palmitoyltransferase activity 0.7342139283869636 1.9075750952286312 0.0564461565735894 1.0 0.3204072920059697 6 O15269,O15498,Q8IUH4,P23786 4 +Atpase coupled cation transmembrane transporter activity 0.5794298516613994 1.9061543744861749 0.0566301797847887 1.0 0.3204072920059697 14 P20020,Q9HD20,P16615,P35670,P05023 5 +Serine type exopeptidase activity 0.720829933999392 1.9036076914753164 0.0569612963566168 1.0 0.3204072920059697 7 O14773,Q9HB40,P42785,P10619 4 +Lysophospholipid acyltransferase activity 0.7195684643726874 1.897483185720503 0.0577641958857446 1.0 0.32129931679554 7 Q9NUQ2,Q8NF37,Q96N66 3 +Lipid transporter activity 0.4896197206178784 1.8906959520515465 0.0586649431311954 1.0 0.3220296012177101 22 P08183,O15118,Q4KMQ2,Q9NV96,P30536,Q96AA3,P17900,Q14849,P28288,P33527 10 +Sodium ion transmembrane transporter activity 0.7290155527941166 1.882875349830018 0.059717262538 1.0 0.3263898964627532 6 Q9H2J7,P05023,Q6P4Q7 3 +Thiolester hydrolase activity 0.5864283046104002 1.8678176818431556 0.061787487978641 1.0 0.3327730588410349 13 Q9UMR5,Q8N2K0,P49327,P50897,Q9NUJ1 5 +Organic cation transmembrane transporter activity 0.773324351633546 1.865455118190343 0.0621176376503265 1.0 0.3327730588410349 5 O43808,Q9HC21,Q70HW3,Q86VD7 4 +Oxidoreductase activity acting on nad p h 0.4494681522113475 1.8635300120886575 0.0623877341037149 1.0 0.3328989764427474 31 O95139,O95825,Q9Y6M9,O43676,O95831,P51970,P16435,Q9P0J0,O75438,O95168,O96000,Q13423,P03886 13 +Peptide binding 0.3731559922792786 1.8435127367901496 0.0652541838202611 1.0 0.3401279851635234 70 Q9H7Z7,P52292,P10321,Q03518,P24390,O00505,Q99735,Q9UIQ6,Q15392,P42892,O14773,Q9NQX7,Q9UHB9,Q9NZ08,Q15388,Q92973,P40855,P04439,O00264,Q8WTV0 20 +Solute anion antiporter activity 0.7645671943415288 1.825649564269621 0.0679030648373193 1.0 0.3459212736995513 5 P41440,P12235,P12236,P05141 4 +Oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen reduced flavin or flavoprotein as one donor and incorporation of one atom of oxygen 0.9639973082099615 1.8123112424761223 0.0699381183961331 1.0 0.3496905919806659 2 P30519 1 +Proton channel activity 0.5966310406349258 1.7869808268652676 0.0739405874828496 1.0 0.3643058142403174 11 P00846,O75964 2 +Proton transporting atp synthase activity rotational mechanism 0.5966310406349258 1.7869808268652676 0.0739405874828496 1.0 0.3643058142403174 11 P00846,O75964 2 +Oxidoreductase activity acting on a heme group of donors 0.754813882223289 1.781147001774268 0.0748884390228628 1.0 0.3649797569706309 5 P00403,P16435,P13073 3 +Tap binding 0.8168350168350221 1.772415985238881 0.0763255302151315 1.0 0.3706455603972216 4 P10321,P04439,Q03518 3 +Solute proton symporter activity 0.8124579124579265 1.7535888873060468 0.0795009765449061 1.0 0.3814476453132568 4 O00400,Q96ES6,Q00325 3 +Fk506 binding 0.6852988099503137 1.7296368709953676 0.0836951741421028 1.0 0.3909636162347363 7 Q96AY3,Q9Y680,P62942 3 +Macrolide binding 0.6852988099503137 1.7296368709953676 0.0836951741421028 1.0 0.3909636162347363 7 Q96AY3,Q9Y680,P62942 3 +2 acylglycerol 3 phosphate o acyltransferase activity 0.8052922118594535 1.7227093455331566 0.0849410994578241 1.0 0.3924405572684644 4 Q8NF37,Q96N66 2 +Protease binding 0.4502285356361346 1.7118475799118762 0.0869247610989591 1.0 0.3977912796054064 27 Q9BUN8,P14174,Q9NZJ7,Q6NTF9,Q8WU17,Q9GZP9,P07602,P46379,P41440,O75955 10 +Udp glycosyltransferase activity 0.5361370492452064 1.701071157776613 0.0889296260899212 1.0 0.4004968825635059 15 Q8N4A0,P06865,Q10472,O43505,Q16739,Q16880 6 +Lysophosphatidic acid binding 0.934387617765818 1.6869739540087636 0.0916083603250905 1.0 0.4041545308459878 2 P50897 1 +Ganglioside binding 0.9441265567149072 1.6767584773027493 0.0935897203881241 1.0 0.40952899044368 3 Q9UM22,P07602 2 +Glycosphingolipid binding 0.9441265567149072 1.6767584773027493 0.0935897203881241 1.0 0.40952899044368 3 Q9UM22,P07602 2 +Copper ion binding 0.6061344363631895 1.672951173814055 0.0943369084174505 1.0 0.409923480464637 10 Q99584,O75880,P35670,P00403,O60888,O43819 6 +Glycosyltransferase activity 0.4021603407704142 1.659729142069412 0.0969689540156482 1.0 0.4113288736223415 48 P46977,P04062,Q8N4A0,Q6ZXV5,Q9H3H5,P43490,Q10472,Q9BV10,Q13126,Q9BT22,Q16739,Q2TAA5,O43505 13 +Acidic amino acid transmembrane transporter activity 0.7895622895622855 1.6546815682055642 0.097989107827157 1.0 0.4113288736223415 4 Q9H936,Q9UJS0,O75746 3 +L aspartate transmembrane transporter activity 0.7895622895622855 1.6546815682055642 0.097989107827157 1.0 0.4113288736223415 4 Q9H936,Q9UJS0,O75746 3 +Oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen nad p h as one donor and incorporation of one atom of oxygen 0.9384045775833004 1.6540883955780668 0.0981095535602918 1.0 0.4113288736223415 3 Q15800,Q14534 2 +Sphingosine n acyltransferase activity 0.923620457604309 1.6412597446803787 0.1007435085276045 1.0 0.4190845575945836 2 Q96G23 1 +Mitochondrial ribosome binding 0.7863040076688947 1.6405506473663305 0.1008907268283256 1.0 0.4190845575945836 4 Q15070 1 +Cation channel activity 0.4604468922039189 1.6328475993772618 0.1025010532115711 1.0 0.4205970268559909 21 P24539,P00846,Q4KMQ2,P56385,Q9NW15,O75964 6 +Nuclear import signal receptor activity 0.5342807673085025 1.6152325813314536 0.1062603373342796 1.0 0.4257796654414829 14 Q92973,O00505,P52292,Q96P70 4 +Glucosidase activity 0.717549189144662 1.609568036994686 0.1074921907338808 1.0 0.4262697082013093 5 P04062 1 +Cargo receptor activity 0.6207935087341251 1.5999207568506026 0.1096161639461319 1.0 0.4326953839978892 9 O15260,Q08380,Q14108,Q9NPF0,Q8WTV0 5 +Zinc ion transmembrane transporter activity 0.921575227196225 1.587283347231677 0.1124484851090852 1.0 0.4379169373487307 3 Q8TAD4,Q6NXT4 2 +Manganese ion transmembrane transporter activity 0.921575227196225 1.587283347231677 0.1124484851090852 1.0 0.4379169373487307 3 Q9HD20,Q9HC07 2 +Hexosaminidase activity 0.6676474312489366 1.5867870974297662 0.1125608720444515 1.0 0.4379169373487307 6 P17900,P54802,P17050 3 +Nadp binding 0.4946878089577625 1.5779740050904525 0.1145715818395722 1.0 0.4441542696640028 17 P16435,P35270,Q9UBM7,P00374,Q13423,Q14739 6 +Mhc class ib protein binding 0.9084791386271898 1.5768844994472364 0.1148221037872125 1.0 0.4441542696640028 2 Q03518 1 +Syntaxin binding 0.4817345882453823 1.5733926852529814 0.1156279196946965 1.0 0.4447227680565251 18 O15400,Q8N1B4,Q9BVK6,Q8WVM8,O60499,O75150,P49755,Q9P253,Q9UNK0 9 +Prenyltransferase activity 0.7073849988817846 1.5623760213487177 0.118199432525563 1.0 0.4506020596224624 5 P49354 1 +Sulfotransferase activity 0.9047779273216708 1.5611360546344557 0.1184916527155364 1.0 0.4506020596224624 2 Q8NCH0 1 +Flavin adenine dinucleotide binding 0.4362763127471947 1.5579339241343355 0.1192489123828757 1.0 0.4506601326336112 26 Q8NB78,O95831,P16435,O15254,Q15067,A1L0T0,Q14534,O00116,Q15392 9 +Nucleobase transmembrane transporter activity 0.9037685060565314 1.556840366120259 0.1195083907280243 1.0 0.4506601326336112 2 P12235 1 +Oxidative phosphorylation uncoupler activity 0.9037685060565314 1.556840366120259 0.1195083907280243 1.0 0.4506601326336112 2 P12235 1 +Intramembrane lipid transporter activity 0.6591055465024609 1.5449638160655732 0.1223550158665895 1.0 0.4568089594379186 6 P08183,Q96AA3,Q4KMQ2,Q9NV96 4 +Neutral amino acid transmembrane transporter activity 0.7639520687428485 1.5432757962750083 0.1227638735867935 1.0 0.4568089594379186 4 Q96NB2,Q15758 2 +Phospholipase d activity 0.897711978465684 1.531061233959587 0.1257542595687288 1.0 0.4602323302046907 2 P09601 1 +Vitamin d binding 0.895693135935403 1.5224665892384903 0.1278922108504894 1.0 0.4636721180431148 2 P04062 1 +Peptide transmembrane transporter activity 0.8930013458950239 1.5110061057733457 0.1307868952460711 1.0 0.4649608242667463 2 Q03518 1 +Exopeptidase activity 0.4109385255173179 1.5032379489514618 0.1327776948328105 1.0 0.4649608242667463 31 Q9NZ08,P42785,O14773,P10619,Q9UIQ6,O75844,Q969V3,Q9HB40 8 +17 beta hydroxysteroid dehydrogenase nadpplus activity 0.8906460296096914 1.5009774674223852 0.1333613896464627 1.0 0.4649608242667463 2 Q53GQ0 1 +C acetyltransferase activity 0.6491226282986559 1.4959173082507995 0.134675205316376 1.0 0.4649608242667463 6 P35610,Q9BWD1 2 +Lipid binding 0.3994481331487279 1.491002473264068 0.1359608455656644 1.0 0.4649608242667463 138 O75477,P35610,Q9Y5X3,O43292,Q8NCC3,Q9UM22,Q9H4A6,Q14849,O95772,Q9Y371,P50897,P05023,P45880,Q9NQZ5,P21796,P04062,Q9H490,Q9NZJ7,P30536,P07602,Q13432,Q8NFH5,P38435,O15173,O14773,Q99584,Q9BQE5,O15254,P28070,O15118,Q14108,O60313,Q9UJZ1,O95219,Q15067,P04083,Q9BWH2,Q8WTV0,O75208,O00264,A6NIH7 41 +Steroid dehydrogenase activity 0.6374132032676295 1.4906854684866302 0.1360440930261961 1.0 0.4649608242667463 7 Q3SXM5,Q53GQ0 2 +Galactoside binding 0.886944818304173 1.4852172644309978 0.1374862800986549 1.0 0.4687032276090509 2 P16278 1 +C acyltransferase activity 0.5719681037491666 1.4793941949433234 0.1390349907188524 1.0 0.4694292944925714 10 O15269,P35610,Q9BWD1 3 +Heme transmembrane transporter activity 0.8839165545087545 1.472322142529737 0.1409339066715635 1.0 0.4720361625123334 2 O15173 1 +Calcium activated cation channel activity 0.8798788694481854 1.4551287896160154 0.145633610304285 1.0 0.4803453703541029 2 Q9NW15 1 +3 hydroxyacyl coa dehydratase activity 0.8795423956931414 1.453696043621553 0.1460305955683094 1.0 0.4803453703541029 2 Q9P035 1 +Leukotriene c4 synthase activity 0.8792059219380897 1.452263305358476 0.14642840637678 1.0 0.4803453703541029 2 Q99735 1 +Atpase binding 0.4217539317267197 1.4305726719071017 0.1525527243145708 1.0 0.4857221175110155 26 Q93050,Q9Y487,Q92542,Q16740,O76024,Q9BUN8 6 +Acetyl coa c acetyltransferase activity 0.6779630219145707 1.4249633197586256 0.154167804353634 1.0 0.4883965188031508 5 P35610,Q9BWD1 2 +Ion gated channel activity 0.8801750252440159 1.4223391536983 0.1549278176689612 1.0 0.4883965188031508 3 Q9C0H2,Q9NW15 2 +Intracellular calcium activated chloride channel activity 0.8801750252440159 1.4223391536983 0.1549278176689612 1.0 0.4883965188031508 3 Q9C0H2,Q9NW15 2 +Amyloid beta binding 0.5323959951148352 1.4033844012930583 0.1605022419570181 1.0 0.4981104060735045 11 Q9NQX7,O00264 2 +Galactosidase activity 0.8694042409962947 1.3793486092277516 0.1677872959737212 1.0 0.5108173106152923 3 P06280,P16278 2 +Mannosyltransferase activity 0.6253878095016216 1.3786517985297562 0.1680021377134739 1.0 0.5108173106152923 6 Q6ZXV5,Q9BT22,Q9BV10 3 +Oxidoreductase activity acting on paired donors with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water 0.8663749579266194 1.3672560176969497 0.1715450724441094 1.0 0.5182581421084826 3 O15121,O00767 2 +Lamin binding 0.6020757518769848 1.3635228126581012 0.1727177998430071 1.0 0.5204665843483475 8 P42167,Q14739 2 +Phosphotransferase activity for other substituted phosphate groups 0.7225589225589251 1.361878088799957 0.1732363621905657 1.0 0.5208665678335495 4 Q9H3H5,O14735,P48651 3 +Galactosyltransferase activity 0.7220854652299084 1.3597963368942882 0.1738943819245786 1.0 0.5216831457737359 4 O43505,Q16880 2 +Atp dependent peptidase activity 0.6618908199244922 1.349477584410841 0.1771836154734922 1.0 0.5268675790511334 5 P36776,Q16740 2 +G protein alpha subunit binding 0.8571941884152094 1.330608782937228 0.1833177710389537 1.0 0.5310707959282994 3 P80303 1 +Floppase activity 0.8495962314939469 1.326282689422769 0.1847460785018153 1.0 0.5317850873719671 2 Q96AA3 1 +Efflux transmembrane transporter activity 0.8495962314939458 1.326282689422765 0.1847460785018166 1.0 0.5317850873719671 2 P33527 1 +Abc type xenobiotic transporter activity 0.8495962314939458 1.326282689422765 0.1847460785018166 1.0 0.5317850873719671 2 P33527 1 +Oxidoreductase activity acting on nad p h quinone or similar compound as acceptor 0.4091594034473801 1.319092866794983 0.1871380676148171 1.0 0.5337971665095191 26 O95139,O95825,Q9Y6M9,O43676,P51970,Q9P0J0,O75438,O95168,O96000,P03886 10 +Growth factor receptor binding 0.4696015484139951 1.3182435946143092 0.18742211624112 1.0 0.5337971665095191 16 Q9NZ08,P18085,Q92542,O95219,Q3ZCQ8,P05067 6 +Misfolded protein binding 0.4987016895887762 1.311926585368566 0.1895449064058141 1.0 0.5365977210492928 13 Q6NTF9,Q9GZP9,P10909,P46379,P38646,Q9BUN8 6 +Dolichyl diphosphooligosaccharide protein glycotransferase activity 0.7107744107743994 1.3100330727547536 0.1901846475341635 1.0 0.5365977210492928 4 P04843,Q8TCJ2,P46977 3 +Oligosaccharyl transferase activity 0.7107744107743994 1.3100330727547536 0.1901846475341635 1.0 0.5365977210492928 4 P04843,Q8TCJ2,P46977 3 +Magnesium ion transmembrane transporter activity 0.8515651295859894 1.3081435024641863 0.1908246406398119 1.0 0.5365977210492928 3 Q9H0U3,Q8IUH4 2 +Acyl coa oxidase activity 0.8452220726783359 1.3077030381033248 0.1909740524841048 1.0 0.5365977210492928 2 Q15067 1 +Atpase coupled inorganic anion transmembrane transporter activity 0.8432032301480511 1.299131917605444 0.1938986611915036 1.0 0.5381664661475755 2 P33527 1 +Structural constituent of nuclear pore 0.4329740572767522 1.293117884713362 0.1959702903817362 1.0 0.5417182669975723 19 Q9BTX1,Q8N1F7,Q9BW27,Q92621,O75694,P57740,Q8NFH5,Q99567,Q7Z3B4 9 +Mhc protein binding 0.564048006837346 1.2916031059447135 0.1964946278846278 1.0 0.5417182669975723 9 Q9NUQ9,Q03518,Q9BUN8 3 +Carbon sulfur lyase activity 0.6491226563678907 1.2893518594656843 0.1972757894932231 1.0 0.5422030171290846 5 P53701,Q99735 2 +Calcium ion transmembrane transporter activity 0.5043698397451192 1.2869178988274876 0.1981229059499811 1.0 0.5425272272463988 12 P20020,Q9HC07,P16615,O95202 4 +Phosphatidylglycerol binding 0.8354643337819672 1.2663034705581733 0.2054044549127394 1.0 0.5489633492279521 2 O60313 1 +Cardiolipin binding 0.8354643337819672 1.2663034705581733 0.2054044549127394 1.0 0.5489633492279521 2 O60313 1 +Epidermal growth factor receptor binding 0.6023647524647273 1.264177748447617 0.2061662355989419 1.0 0.5489633492279521 6 P18085 1 +Plus end directed microtubule motor activity 0.6941269664609843 1.2367267900731735 0.216188529332111 1.0 0.5562985445793859 4 Q86Y91 1 +Ionotropic glutamate receptor binding 0.635218741657264 1.2237680074044817 0.2210397563480677 1.0 0.5617397083963964 5 P27824,O75955 2 +Hydrolase activity acting on carbon nitrogen but not peptide bonds in linear amides 0.5272569539434082 1.2218487742991349 0.2217648200414448 1.0 0.5617397083963964 10 Q13510 1 +Phosphatidyl phospholipase b activity 0.8243606998654126 1.219293099263486 0.2227329668566287 1.0 0.5617397083963964 2 Q8IY17 1 +Phospholipid binding 0.3387333311525189 1.215280165529585 0.2242592541430181 1.0 0.5637802478455763 85 Q9Y5X3,O43292,Q8NCC3,Q9UM22,Q9H4A6,P50897,P45880,P21796,Q9H490,Q9NZJ7,P07602,Q8NFH5,Q92643,O14773,Q14108,O60313,Q9UJZ1,O95219,P04083,Q9BWH2,Q8WTV0 21 +Folic acid transmembrane transporter activity 0.8223418573351385 1.2107593183151255 0.2259876608659738 1.0 0.5640692445341291 2 Q9H2D1 1 +Scavenger receptor activity 0.6306832973082952 1.2023590597298788 0.2292244438761534 1.0 0.5668771202619588 5 Q14108,Q8WTV0 2 +Xenobiotic transmembrane transporter activity 0.8226186469202232 1.1927819031928792 0.2329547992854688 1.0 0.569810299240326 3 P08183,P33527 2 +Modified amino acid transmembrane transporter activity 0.8226186469202156 1.1927819031928493 0.2329547992854805 1.0 0.569810299240326 3 Q9H2D1,P33527 2 +Volume sensitive anion channel activity 0.8176312247644801 1.1908655333990334 0.2337063771131184 1.0 0.569810299240326 2 Q9C0H2 1 +Solute proton antiporter activity 0.8176312247644751 1.1908655333990126 0.2337063771131267 1.0 0.569810299240326 2 O95202 1 +Transferase activity transferring sulphur containing groups 0.5780051749233573 1.1886524497715565 0.2345764592623984 1.0 0.5705913873950232 7 Q8NCH0,Q5VV42,Q7LGA3 3 +P type calcium transporter activity 0.8166218034993311 1.1866061013952691 0.2353830281220525 1.0 0.5706610948794637 2 P16615 1 +Protein lipid complex binding 0.6823682797664226 1.1849425814022236 0.2360401499381093 1.0 0.5706610948794637 4 Q9BQE5 1 +Flippase activity 0.8149394347240926 1.179509944632343 0.2381951791458649 1.0 0.5711385781204125 2 P08183 1 +Ribosome binding 0.3725377653592553 1.1769394154691704 0.2392196885149395 1.0 0.5715868663631299 38 P60059,O95202,P46379,Q969V3,Q9NTK5,Q8WWC4,Q96A33,Q7Z739,Q07021,Q9UHB9,Q15070 11 +Voltage gated chloride channel activity 0.8179064288118434 1.1740448787093 0.2403770501603832 1.0 0.5723791983580923 3 P51798,Q4KMQ2 2 +Amino acid cation symporter activity 0.8119111709286732 1.1667463200970876 0.2433128308674776 1.0 0.5755028854519936 2 Q9H2J7 1 +Cis trans isomerase activity 0.3918503654794472 1.1645546086393463 0.2441993265203257 1.0 0.5755028854519936 26 Q9Y680,Q96AY3,O15121,Q9NWM8,O95302 5 +Atpase coupled intramembrane lipid transporter activity 0.815213732749908 1.1633455357978078 0.2446893375409236 1.0 0.5755028854519936 3 Q96AA3,P08183 2 +Lipid kinase activity 0.8109017496635256 1.1624945772508086 0.2450346261258795 1.0 0.5755028854519936 2 Q53H12 1 +Phospholipid transporter activity 0.5704974034181044 1.1502080866214488 0.250058176363924 1.0 0.5813020301391261 7 P08183,Q4KMQ2,Q9NV96 3 +Signal sequence binding 0.3868647770005658 1.1452039456606504 0.2521246842899334 1.0 0.5813020301391261 27 P24390,O00505,P40855,Q92973,P52292,Q9UHB9 6 +Gpi anchor binding 0.8105015146415238 1.1446362167903 0.252359883208753 1.0 0.5813020301391261 3 Q9H490,O43292 2 +High density lipoprotein particle binding 0.8097452883230227 1.1416355404464598 0.2536055446353091 1.0 0.5813020301391261 3 Q9BQE5 1 +Chloride channel inhibitor activity 0.805181695827726 1.138429387972089 0.2549412284455288 1.0 0.5813020301391261 2 Q9UNK0 1 +Polypeptide n acetylgalactosaminyltransferase activity 0.8088224793503009 1.1379745906204537 0.2551310925742593 1.0 0.5813020301391261 3 Q8N4A0 1 +Acetylgalactosaminyltransferase activity 0.8088224793503009 1.1379745906204537 0.2551310925742593 1.0 0.5813020301391261 3 Q8N4A0 1 +Collagen binding 0.5117615454602908 1.131805399782429 0.2577162570635769 1.0 0.5813020301391261 10 O75718,Q53GQ0,Q92791,P07858 4 +Modified amino acid binding 0.4005974940144836 1.1260076034415076 0.2601623009792118 1.0 0.5822016838869637 20 Q99735,Q14108,Q9H7Z7,P41440,P49327,P00374,Q8WTV0 7 +Signal recognition particle binding 0.5740590011786573 1.1228242330931908 0.2615121512473821 1.0 0.5822016838869637 6 Q9GZP9,Q9BUN8 2 +Amide binding 0.3453474283242408 1.1220670073927714 0.2618339505052969 1.0 0.5822016838869637 102 Q9Y680,P35610,Q9UM22,Q9H7Z7,P41440,P10321,P45880,Q03518,P52292,P24390,P21796,O00505,Q99735,Q9UIQ6,Q9NZJ7,P07602,Q15392,P42892,O14773,Q96AY3,Q9NQX7,P49327,P40939,Q9UHB9,Q9NZ08,Q15388,P00374,P62942,Q92973,P40855,P04439,O00264,Q8WTV0 33 +Peptide receptor activity 0.7967698519515503 1.1031338118725464 0.2699690593676802 1.0 0.5887855091217582 2 Q99720 1 +G protein coupled receptor activity 0.7970380343318733 1.091300130265609 0.275140840463294 1.0 0.5949135371478156 3 Q9NRA0,Q99720 2 +Solute cation antiporter activity 0.7955638218488422 1.0854722208822791 0.2777125606663126 1.0 0.5949135371478156 3 O95202 1 +L serine transmembrane transporter activity 0.7883580080753678 1.067965208842696 0.2855362057960042 1.0 0.6041910310730497 2 Q15758 1 +Serine transmembrane transporter activity 0.7886233591383371 1.0580721114145062 0.2900225677860557 1.0 0.6062672187813263 3 Q96NB2,Q15758 2 +Threonine type endopeptidase activity 0.5436787471126108 1.0576165664408648 0.2902302866961936 1.0 0.6062672187813263 8 P49721,P28070 2 +Threonine type peptidase activity 0.5436787471126108 1.0576165664408648 0.2902302866961936 1.0 0.6062672187813263 8 P49721,P28070 2 +Beta 1 3 galactosyltransferase activity 0.7849932705249083 1.0539371535259 0.2919116913179578 1.0 0.6062672187813263 2 O43505 1 +Catalytic activity acting on a glycoprotein 0.7849932705249083 1.0539371535259 0.2919116913179578 1.0 0.6062672187813263 2 O43505 1 +Udp galactose beta n acetylglucosamine beta 1 3 galactosyltransferase activity 0.7849932705249083 1.0539371535259 0.2919116913179578 1.0 0.6062672187813263 2 O43505 1 +Protein prenyltransferase activity 0.7806191117092982 1.0357370664726298 0.3003248248170516 1.0 0.6132408909718262 2 P49354 1 +Procollagen proline dioxygenase activity 0.7794443399978987 1.0219388070425233 0.30680986372447 1.0 0.6187625562933972 3 P13674 1 +Peptidyl proline dioxygenase activity 0.7794443399978987 1.0219388070425233 0.30680986372447 1.0 0.6187625562933972 3 P13674 1 +Lysophospholipase activity 0.5894022777567471 1.007631236663202 0.3136315273497976 1.0 0.6217597709684357 5 Q8NCC3,Q8IY17,Q8N2K0 3 +Quaternary ammonium group transmembrane transporter activity 0.7725437415881651 1.0022532770052373 0.3162212822704942 1.0 0.6231780687281104 2 Q9HC21 1 +Phosphatidylinositol phosphate phosphatase activity 0.5495597793561584 1.0003763826529437 0.3171283949749717 1.0 0.6231780687281104 6 Q10713,Q8WUK0 2 +Hormone binding 0.5399160127015215 0.9934848440074404 0.320473732815584 1.0 0.6257792910059118 7 P05023,P42892 2 +Ubiquinol cytochrome c reductase activity 0.7717940087512442 0.9919265237536918 0.3212333693830347 1.0 0.6257792910059118 3 Q9UDW1,P08574 2 +Oxidoreductase activity acting on diphenols and related substances as donors 0.7717940087512442 0.9919265237536918 0.3212333693830347 1.0 0.6257792910059118 3 Q9UDW1,P08574 2 +Ribosomal protein s6 kinase activity 0.7678331090174999 0.982796385323028 0.3257076612438938 1.0 0.6303143830400134 2 P51812 1 +Peroxisome targeting sequence binding 0.7641318977119848 0.9675506445759544 0.3332688366041454 1.0 0.6418158764844455 2 P40855 1 +Sulfuric ester hydrolase activity 0.7631224764468422 0.963399361092136 0.3353471468208333 1.0 0.6439810074084282 2 O43681 1 +Acetyl coa c acyltransferase activity 0.5304884862642345 0.9452384146965844 0.3445371716360554 1.0 0.6540701147918323 7 P35610,Q9BWD1 2 +S methyltransferase activity 0.7596609360706197 0.9445513767727042 0.3448879606546473 1.0 0.6540701147918323 3 Q03164 1 +Solute sodium symporter activity 0.7584118438761869 0.9440658685281142 0.3451359896182635 1.0 0.6540701147918323 2 Q9H2J7 1 +Phosphatidylethanolamine binding 0.6252525252525287 0.9346817950057004 0.349952311608559 1.0 0.6594126980925079 4 Q9BSJ8,P50995,P30086 3 +Phosphoric diester hydrolase activity 0.4757992793674932 0.92236208898545 0.3563397376258499 1.0 0.6642556680579195 10 Q8N2A8,P09601 2 +S acyltransferase activity 0.5296177270392709 0.9010161870836432 0.3675797132152985 1.0 0.6768832763241783 6 Q8IUH4,P49327 2 +Metallopeptidase activity 0.3439724876026672 0.8985516724594818 0.3688915101722267 1.0 0.6768832763241783 40 Q9NZ08,P42892,Q5JRX3,Q9UIQ6,P55786,O75844,Q969V3,P02786,Q99797,Q96TA2,Q10713,Q9BYT8,P22695 13 +Snare binding 0.3502438735092948 0.8847485070293865 0.376292287387673 1.0 0.6852674335531534 30 Q12846,O15400,P51809,Q13190,Q8N1B4,Q86Y82,Q9BVK6,Q8WVM8,O60499,O75150,P49755,Q9P253,Q9UNK0 13 +Estradiol 17 beta dehydrogenase activity 0.6133255417822938 0.8830180088016061 0.3772265414832936 1.0 0.6852674335531534 4 Q53GQ0 1 +17 beta hydroxysteroid dehydrogenase nadplus activity 0.6133255417822938 0.8830180088016061 0.3772265414832936 1.0 0.6852674335531534 4 Q53GQ0 1 +O palmitoyltransferase activity 0.741924629878882 0.8769546193764295 0.3805112873921663 1.0 0.6856480758987208 2 P23786 1 +Nadplus kinase activity 0.6096602370073592 0.8672071565044324 0.3858285158159846 1.0 0.6879762599683226 4 Q9NRA0,Q53H12 2 +2 iron 2 sulfur cluster binding 0.5063597809800195 0.8617261676875863 0.3888382222742188 1.0 0.6879762599683226 8 Q9NZ45,P21912 2 +Nadph binding 0.6052949118305637 0.8484220320015117 0.3962029770038269 1.0 0.6879762599683226 4 Q14739 1 +Phosphatidylinositol 4 5 bisphosphate phosphatase activity 0.7345836106764789 0.8477010346492929 0.3966044900088787 1.0 0.6879762599683226 3 Q10713 1 +Phosphatidylinositol 4 5 bisphosphate 5 phosphatase activity 0.7345836106764789 0.8477010346492929 0.3966044900088787 1.0 0.6879762599683226 3 Q10713 1 +Phosphatidylinositol phosphate 5 phosphatase activity 0.7345836106764789 0.8477010346492929 0.3966044900088787 1.0 0.6879762599683226 3 Q10713 1 +Sulfatide binding 0.7344039309291575 0.8470131665939696 0.3969877826039432 1.0 0.6879762599683226 3 P50897 1 +Mhc class i protein binding 0.5032974802211003 0.8457221852961687 0.3977077438677954 1.0 0.6883403259250306 8 Q03518,Q9BUN8 2 +Oxidoreductase activity acting on the ch nh2 group of donors 0.7338492597577388 0.8444370439131599 0.3984252294601853 1.0 0.6886991802448785 2 P00367 1 +Oxidoreductase activity acting on the ch ch group of donors oxygen as acceptor 0.6018571038321814 0.8336652131761878 0.4044696660663205 1.0 0.694370726947859 4 Q15067 1 +Transcription coactivator binding 0.6013379180781333 0.8314395619969008 0.4057253575233435 1.0 0.6947573417879562 4 Q00059 1 +Ubiquitin specific protease binding 0.4556948354222732 0.8057196278318924 0.4204045294955461 1.0 0.7072305531214915 10 Q6NTF9,Q9GZP9,Q9BUN8 3 +O methyltransferase activity 0.5029991308678132 0.8052573110431597 0.420671210486339 1.0 0.7072305531214915 7 P21964 1 +Fatty acid synthase activity 0.7217362045760531 0.7961582689716801 0.4259400496618835 1.0 0.7140920101014909 2 P49327 1 +Phosphatidylinositol bisphosphate phosphatase activity 0.5427526979406061 0.790025082419299 0.4295131201499338 1.0 0.7140920101014909 5 Q10713 1 +Acyltransferase activity 0.3116062992893524 0.7816960870863221 0.4343932018094967 1.0 0.7195470214022337 55 O15269,Q9NUQ2,Q8IUH4,P35610,P27544,Q8NF37,Q96G23,P23786,Q9BWD1,Q96N66 10 +Structural constituent of eye lens 0.7161091581002934 0.7775103360051545 0.4368577387471801 1.0 0.7218579526422194 3 Q99797 1 +Peptidase activity 0.3245020021065573 0.7665842076215661 0.4433287679134783 1.0 0.7294787695670526 109 P42785,O43292,Q16740,Q969V3,Q10713,P07858,Q9UIQ6,Q9HB40,Q9BXS4,P49721,P42892,O14773,Q9BT78,Q15005,O75844,P28070,Q9H3G5,Q9NZ08,P10619,Q6NTF9,P28072,Q92542,P67812,Q13043,Q99797,P22695,Q4J6C6 27 +G protein activity 0.426948164722911 0.7567529187262911 0.449197904304345 1.0 0.7324119446422704 11 P62820,Q9H0U4,P61026,P61020 4 +Cysteine type endopeptidase regulator activity involved in apoptotic process 0.5000219249966087 0.7549187844355969 0.4502977141133959 1.0 0.7324119446422704 6 P51812,Q9BXK5 2 +Acyl coa binding 0.4201722126119167 0.7155538560284123 0.4742668749268577 1.0 0.7419006734081783 11 Q9H3P7,P22307,Q02252,P35610,P49748,P40939,Q9H845,Q5T8D3 8 +Fatty acid derivative binding 0.4201722126119167 0.7155538560284123 0.4742668749268577 1.0 0.7419006734081783 11 Q9H3P7,P22307,Q02252,P35610,P49748,P40939,Q9H845,Q5T8D3 8 +Steroid dehydrogenase activity acting on the ch oh group of donors nad or nadp as acceptor 0.5252908429418096 0.7101147465126396 0.4776329824058334 1.0 0.743719176756488 5 Q53GQ0 1 +L ascorbic acid binding 0.5718657315155099 0.7066075829040979 0.4798103753070337 1.0 0.7454975585464333 4 P13674 1 +Channel inhibitor activity 0.6968364276123373 0.7056083020511452 0.4804317599521459 1.0 0.7454975585464333 3 P62942 1 +Oxidoreductase activity 0.3827897671852712 0.6896582238897447 0.4904091431468291 1.0 0.7556237718142934 210 O43169,Q8NBX0,P13073,P14406,Q8N0U8,P09622,Q15800,Q53GQ0,Q96JJ7,Q9H7Z7,Q9H3N1,O95864,P30519,Q9NZ01,P00403,Q8WWV3,O96000,Q13423,Q9UDW1,Q96LJ7,Q16836,Q9H9P8,O95139,O95825,Q99735,Q9Y6M9,O43676,O95831,P51970,P16435,O75438,P11177,Q14534,Q14739,Q16850,Q9UBM7,O00116,Q15392,Q96CU9,O00767,Q8NBQ5,Q6NUM9,Q9Y320,Q9UHG3,Q9P0J0,O15254,O95881,Q8N4Q0,Q3SXM5,P35270,P49327,P40939,Q6UW02,Q9BU89,P21912,P51649,Q9BY49,P51648,O43819,P03886,Q8NBN7,O14880,Q8NB78,O15121,P09601,Q15067,P08574,Q06136,O95168,Q9Y394,P13674,P00374 72 +Dynein light chain binding 0.690107671601615 0.6734596811484236 0.5006548909806867 1.0 0.7556237718142934 2 Q13409 1 +Metalloexopeptidase activity 0.3548575326857562 0.6734066200541166 0.5006886381491218 1.0 0.7556237718142934 19 O75844,Q969V3 2 +Translation repressor activity 0.4515193880549144 0.6729948384719965 0.5009505746472538 1.0 0.7556237718142934 9 P34897,P00374,Q14011 3 +Glycolipid mannosyltransferase activity 0.6884253028263889 0.6670902278905341 0.5047145017288344 1.0 0.7596037651437307 2 Q2TAA5 1 +Structural constituent of postsynapse 0.6860438857857405 0.666038241105266 0.5053866577675659 1.0 0.7597683607864297 3 Q16352 1 +3 hydroxyacyl coa dehydrogenase activity 0.4814407892512272 0.6646296589951333 0.5062873943472821 1.0 0.7600722494530762 6 P40939,Q53GQ0 2 +Glutathione peroxidase activity 0.5571428282302908 0.645614170138396 0.5185292581373742 1.0 0.7705817715954228 4 Q99735 1 +Oxidoreductase activity acting on a sulfur group of donors disulfide as acceptor 0.6820323014804938 0.6430488503306467 0.5201924026441742 1.0 0.7717140039226761 2 O95881 1 +Folic acid binding 0.6767492943086186 0.6324126733942307 0.5271172547638074 1.0 0.7777139824384044 3 P00374 1 +Fatty acid ligase activity 0.5069046817110128 0.6274141130566464 0.5303878189903968 1.0 0.7791291551867423 5 Q6P1M0,O95573,Q4G176,P33121 4 +Beta n acetylhexosaminidase activity 0.5493971256144244 0.6139781021846112 0.5392297975915739 1.0 0.7848067785158725 4 P17900 1 +Glutamate receptor binding 0.4638258809229622 0.6095793119118726 0.542140519458886 1.0 0.7853221072055588 7 P27824,O75955 2 +Carboxypeptidase activity 0.3960852970209354 0.6045163310808489 0.5455004148872247 1.0 0.7853221072055588 12 Q9HB40,P42785,P10619 3 +Pyruvate dehydrogenase activity 0.5444710923229055 0.5940388412614576 0.5524861346572161 1.0 0.7892659066531659 4 P09622 1 +Oxidoreductase activity acting on a sulfur group of donors 0.3301827577387988 0.5818509533197466 0.5606670796058848 1.0 0.7961520883489176 24 Q9Y320,Q96JJ7,Q9UHG3,O95881,Q9H3N1,O43819 6 +Nucleocytoplasmic carrier activity 0.3299277574250974 0.5514986441010151 0.581291895900367 1.0 0.8081112028539139 21 O00505,Q92973,P52292,Q96P70 4 +Sterol transporter activity 0.4091701146655645 0.5412268376612774 0.5883512414186647 1.0 0.8138055081098333 10 Q14849,O15118 2 +General transcription initiation factor activity 0.4832712541993095 0.5239928835931201 0.6002834895557454 1.0 0.8209892907253177 5 Q9Y6J9,P35269 2 +Cytochrome b5 reductase activity acting on nad p h 0.6455738808481818 0.5231892913676068 0.6008425327678621 1.0 0.8209892907253177 3 Q9UHQ9,P16435 2 +Oxidoreductase activity acting on nad p h heme protein as acceptor 0.6455738808481818 0.5231892913676068 0.6008425327678621 1.0 0.8209892907253177 3 Q9UHQ9,P16435 2 +Transferase activity transferring alkyl or aryl other than methyl groups 0.3346547441752145 0.5162772076736578 0.6056608127248868 1.0 0.8250677065374341 19 O14880,P49354,P37268,Q99735 4 +Glutathione transferase activity 0.4800060649450642 0.5100127443641355 0.610042533329546 1.0 0.826864879512939 5 Q99735 1 +Lipase activity 0.3471750848803022 0.4962245415275008 0.6197359979335757 1.0 0.8366435972103272 17 Q8N2A8,Q8NCC3,P09601,Q8IV08,Q8NHP8,Q9H6V9,Q8IY17 7 +Cytokine activity 0.4445574672777456 0.4908967409986219 0.6234994821954507 1.0 0.8400442125387809 6 P43490 1 +Glycosaminoglycan binding 0.3379637545595895 0.48245833921838 0.6294803866151102 1.0 0.8408667948347387 18 Q06481,P15586,Q53GQ0,O14737,Q07021,P05067 6 +Pdz domain binding 0.3733805401344346 0.4669366503237769 0.6405452026173748 1.0 0.8480787801818778 12 Q15058,Q15067,P51790 3 +Apolipoprotein binding 0.5108111235701859 0.4622365901138758 0.6439116664343887 1.0 0.8480787801818778 4 Q8WTV0 1 +N6 methyladenosine containing rna binding 0.4675244213601378 0.4573765654990241 0.6474004053526958 1.0 0.8495599559186383 5 P22626 1 +Neurexin family protein binding 0.6295423956931431 0.4571635747468346 0.647553477511313 1.0 0.8495599559186383 2 O00560 1 +Guanylate kinase activity 0.629542395693141 0.4571635747468282 0.6475534775113176 1.0 0.8495599559186383 2 Q00013 1 +Sh2 domain binding 0.4251517194875243 0.4494343451332389 0.6531183601305939 1.0 0.8534900845463547 8 P46108,Q6PD62,Q13501,P63244,Q14118,P37198,Q07666 7 +Arachidonate coa ligase activity 0.506734006733998 0.4468786716055682 0.6549626643737705 1.0 0.8534900845463547 4 Q6P1M0,O95573,P33121 3 +Long chain fatty acid coa ligase activity 0.506734006733998 0.4468786716055682 0.6549626643737705 1.0 0.8534900845463547 4 Q6P1M0,O95573,P33121 3 +Phospholipase binding 0.5049304394205825 0.4401321033798842 0.6598414316182095 1.0 0.8581752723358217 4 P07196 1 +Translation repressor activity mrna regulatory element binding 0.4310980897964525 0.4300454869928432 0.6671625530386458 1.0 0.8626398391382051 6 P34897,P00374 2 +Aldo keto reductase nadp activity 0.4049194758848443 0.4285100046770693 0.668279851205192 1.0 0.8626398391382051 9 P35270,Q8NBN7 2 +Protein phosphatase regulator activity 0.3362649558049315 0.4195341001109856 0.6748258386632877 1.0 0.8659837283226601 17 Q86XL3,Q01105,P30154 3 +Mannose binding 0.4576024600082614 0.4165353261554582 0.6770183231093716 1.0 0.8676330483106088 5 P35613 1 +Phosphatidylserine binding 0.3815442589696337 0.3914734353875128 0.6954473206015592 1.0 0.8848764211235673 10 Q14108 1 +Rna strand annealing activity 0.4489727180868964 0.3818155402694894 0.7025981910455741 1.0 0.892293093049412 5 P23588,O00571,Q06787,P51114 4 +Potassium ion binding 0.4172542934308491 0.369315463219428 0.7118926010106641 1.0 0.8965065404518625 6 P35610 1 +Armadillo repeat domain binding 0.5992597577389034 0.3614752404528122 0.7177442107622252 1.0 0.9003578846512422 2 A5YKK6 1 +Phosphatase regulator activity 0.3046423436439205 0.3469555294360548 0.7286247282398737 1.0 0.9072082657033032 20 Q86XL3,P35269,Q01105,P30154 4 +Mirna binding 0.3526292911016993 0.3461129322750043 0.7292578448446991 1.0 0.9072082657033032 12 P09651,P98175,Q14671,P22626 4 +Sulfurtransferase activity 0.5877739250615226 0.3395270307010778 0.7342127375897567 1.0 0.9072082657033032 3 O75648 1 +Nadp retinol dehydrogenase activity 0.4101931472637224 0.33916725711787 0.7344837339252428 1.0 0.9072082657033032 6 Q9BTZ2,Q8NBN7,Q9Y394 3 +Heparin binding 0.3464718728961983 0.3380377756126322 0.73533472082093 1.0 0.90740573410261 13 Q06481,Q53GQ0,P05067,O14737 4 +Dynactin binding 0.4743220761498323 0.330541962464934 0.7409904911844674 1.0 0.910224898179282 4 Q9UNH7,Q9Y5X3 2 +Cysteine type endopeptidase inhibitor activity involved in apoptotic process 0.4690796970633417 0.3127988945626683 0.7544334552849143 1.0 0.9189425689223528 4 P51812 1 +Alkali metal ion binding 0.3981918461342455 0.3047324757134609 0.760569913227525 1.0 0.920044249872006 7 P35610 1 +Rna polymerase ii general transcription initiation factor activity 0.462822060561892 0.2920546535278771 0.770244837089509 1.0 0.9254247415412228 4 P35269 1 +Calcium channel regulator activity 0.4229623333667085 0.2823779632568663 0.7776537105074643 1.0 0.9290553178629 5 P62942 1 +Kinesin binding 0.3734130397635784 0.2751750239527625 0.7831817745211671 1.0 0.9317341394040454 9 Q86Y91 1 +Ferric iron binding 0.5518169582772645 0.233217851260226 0.8155922447051458 1.0 0.9483630752385416 2 P31350 1 +Chaperone binding 0.2783876077650942 0.2239718868571158 0.8227791785959382 1.0 0.9534350996605292 41 O43615,P01889,Q96KC8,Q9Y5J7,Q14108,P10909,P02786,O43808,P05023 9 +Acetylglucosaminyltransferase activity 0.440246126635756 0.2214489682749537 0.82474286755632 1.0 0.954707025814638 4 O43505 1 +Lipid transfer activity 0.3755178267159602 0.2110174344067704 0.8328736669728813 1.0 0.9585502561068966 7 Q14849 1 +Sterol transfer activity 0.4005872759009939 0.204190681811241 0.8382044927988463 1.0 0.9616599910199406 5 Q14849 1 +Beta tubulin binding 0.3091221960246043 0.2039539759744526 0.838389464724925 1.0 0.9616599910199406 16 O75381,O14737 2 +Cobalamin binding 0.4289562289562212 0.1888242913762118 0.8502305325461843 1.0 0.9681488413338 4 Q99707,Q9NPF0,Q96EY8 3 +Protein methyltransferase activity 0.2826509385121325 0.1858515426208327 0.8525611834260429 1.0 0.9681488413338 22 Q9H1A3,Q9BV86,O60725 3 +G quadruplex rna binding 0.5272543741588274 0.1786048227462986 0.8582480073801686 1.0 0.9736426974480904 2 Q9H2U1 1 +Phospholipid scramblase activity 0.5202107724618803 0.1674959649546685 0.8669798221820011 1.0 0.9745401831354716 3 Q4KMQ2 1 +G protein beta subunit binding 0.5131224764468497 0.1510515519896384 0.8799350497883913 1.0 0.9858193503853346 2 Q9UBI6 1 +Poly pyrimidine tract binding 0.3076940735283918 0.1458765396209375 0.8840188521217403 1.0 0.98726960336927 14 P26368,P31943,Q07666 3 +Very long chain fatty acid coa ligase activity 0.5065634466509511 0.1394784583831307 0.8890720772610783 1.0 0.9903030563551616 3 Q6P1M0,Q4G176 2 +Signaling receptor regulator activity 0.2741973887040635 0.125465943689578 0.9001546849504738 1.0 0.9977008587861654 21 P14174,P49354,P43490,P05067,Q9NPF0 5 +Nucleotidase activity 0.3524345970906614 0.1198750716864928 0.9045821119661231 1.0 0.9977008587861654 6 Q969T7 1 +Nitric oxide synthase binding 0.4919246298788833 0.1150558412773241 0.908400860940776 1.0 0.9990783316078892 2 P0DP25 1 +Molybdopterin cofactor binding 0.4909152086137421 0.1134999925591776 0.909634168981008 1.0 0.9991913166186824 2 Q9NQX3 1 +Phosphatidylinositol 3 kinase binding 0.4920902053180559 0.1124115778355907 0.9104970757280136 1.0 0.9993260587258684 3 O14654,P0DP25 2 +Scaffold protein binding 0.2929992776858549 0.1100837680613499 0.9123429411232588 1.0 1.0 16 P08670,Q9NZJ7,P07602,P12956,P17480 5 +Thiol oxidase activity 0.4900706832716148 0.1088529099883601 0.9133191570045692 1.0 1.0 3 P07237,Q96HE7 2 +Pyrophosphate hydrolysis driven proton transmembrane transporter activity 0.3443606003405521 0.1015903504009082 0.9190818390845484 1.0 1.0 8 P36543,P06576,P61421,P21283 4 +Atpase coupled ion transmembrane transporter activity 0.3443606003405521 0.1015903504009082 0.9190818390845484 1.0 1.0 8 P36543,P06576,P61421,P21283 4 +Phosphatidic acid binding 0.3927862323706996 0.0976671036122437 0.9221966381483864 1.0 1.0 4 O60313 1 +Cell cell adhesion mediator activity 0.2876341884184529 0.080600064506943 0.9357600149045048 1.0 1.0 16 P61026,P35613,Q08722 3 +Poly a specific ribonuclease activity 0.3396226415094361 0.0793185147887034 0.9367792800258248 1.0 1.0 6 A5YKK6,O95453,Q9NZN8,Q9HBH5,Q6L8Q7 5 +Nuclear localization sequence binding 0.2862623432329374 0.0732149666009351 0.941635056726534 1.0 1.0 16 Q92973,O00505 2 +Sumo ligase activity 0.4498654104979805 0.0618558230394326 0.95067764819866 1.0 1.0 2 Q96MF7 1 +Copper chaperone activity 0.4473518009058522 0.0459623204977516 0.963340282039348 1.0 1.0 3 O43819 1 +Metallochaperone activity 0.4473518009058522 0.0459623204977516 0.963340282039348 1.0 1.0 3 O43819 1 +Mdm2 mdm4 family protein binding 0.3438868305826863 0.0441698825434949 0.9647689888627308 1.0 1.0 5 P60866,P61927,P04637,P61289 4 +Chloride channel regulator activity 0.4410177533135505 0.0385931442912433 0.969214768285458 1.0 1.0 3 Q9UNK0 1 +Amp activated protein kinase activity 0.4145356662180351 0.0336961454683494 0.9731194526994236 1.0 1.0 2 P54646 1 +Acid thiol ligase activity 0.3242253480585201 0.0330637498100385 0.973623750395318 1.0 1.0 8 Q96I99,O95573,P53597,Q4G176 4 +Channel regulator activity 0.2879307345257215 0.0323365652346611 0.974203649602 1.0 1.0 13 Q13586,O15400,P62942,Q9UNK0 4 +Anaphase promoting complex binding 0.4315045439245996 0.0284219924699286 0.9773255838308016 1.0 1.0 3 Q12834,P53350 2 +Metal dependent deubiquitinase activity 0.322210987529496 0.0271774991588556 0.9783181621464894 1.0 1.0 7 O15372,Q7L5N1,O00303,Q92905,O00487,P51665 6 +Proteoglycan binding 0.333953037684598 0.0224662582068104 0.9820760272531568 1.0 1.0 5 O00560,P07858 2 +Poly a binding 0.2876019230130888 0.0152208979299128 0.9878559494556136 1.0 1.0 11 O14979 1 +Sulfate binding 0.3667563930013451 0.0134816077567459 0.9892435591543184 1.0 1.0 2 P15586 1 +Camp dependent protein kinase inhibitor activity 0.3543068640645997 0.0105985171377972 0.9915437651214324 1.0 1.0 2 P10644 1 +Chemokine binding 0.3283983849259765 0.0066682444595747 0.994679550127472 1.0 1.0 2 P05556 1 +Long chain fatty acyl coa binding 0.3186406460296027 0.0057334101646395 0.99542542561146 1.0 1.0 2 P22307 1 +Complement binding 0.4041357144295109 0.0047785345793449 0.9961872955460154 1.0 1.0 3 P35232 1 +Opsonin binding 0.4041357144295109 0.0047785345793449 0.9961872955460154 1.0 1.0 3 P35232 1 +14 3 3 protein binding 0.3380471380471376 0.0012097761293382 0.999034738539826 1.0 1.0 4 P78362,Q8N122,Q9UBF8 3 diff --git a/msigdb_gomf/selections.json b/msigdb_gomf/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..e0e0643dbf27412561dbb05b3039955613be46d7 --- /dev/null +++ b/msigdb_gomf/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["1 4 alpha oligoglucan phosphorylase activity", "1 acylglycerophosphocholine o acyltransferase activity", "1 alkyl 2 acetylglycerophosphocholine esterase activity", "1 phosphatidylinositol 4 kinase activity", "1 phosphatidylinositol 4 phosphate 5 kinase activity", "1 phosphatidylinositol binding", "14 3 3 protein binding", "17 beta hydroxysteroid dehydrogenase nadplus activity", "17 beta hydroxysteroid dehydrogenase nadpplus activity", "2 acylglycerol 3 phosphate o acyltransferase activity", "2 acylglycerol o acyltransferase activity", "2 iron 2 sulfur cluster binding", "2 oxoglutarate dependent dioxygenase activity", "3 5 dna helicase activity", "3 5 exodeoxyribonuclease activity", "3 5 exonuclease activity", "3 beta hydroxy delta5 steroid dehydrogenase activity", "3 hydroxyacyl coa dehydratase activity", "3 hydroxyacyl coa dehydrogenase activity", "4 iron 4 sulfur cluster binding", "5 3 dna helicase activity", "5 3 exodeoxyribonuclease activity", "5 3 exonuclease activity", "5 deoxyribose 5 phosphate lyase activity", "5s rrna binding", "7s rna binding", "7sk snrna binding", "Abc type glutathione s conjugate transporter activity", "Abc type transporter activity", "Abc type xenobiotic transporter activity", "Acetyl coa c acetyltransferase activity", "Acetyl coa c acyltransferase activity", "Acetyl coa hydrolase activity", "Acetylcholine receptor binding", "Acetylgalactosaminyltransferase activity", "Acetylglucosaminyltransferase activity", "Acetyltransferase activity", "Acid amino acid ligase activity", "Acid phosphatase activity", "Acid thiol ligase activity", "Acidic amino acid transmembrane transporter activity", "Actin binding", "Actin filament binding", "Actin monomer binding", "Actinin binding", "Active ion transmembrane transporter activity", "Active transmembrane transporter activity", "Activin binding", "Acyl carnitine transmembrane transporter activity", "Acyl coa binding", "Acyl coa dehydrogenase activity", "Acyl coa oxidase activity", "Acylglycerol lipase activity", "Acylglycerol o acyltransferase activity", "Acyltransferase activity", "Acyltransferase acyl groups converted into alkyl on transfer", "Adenosine deaminase activity", "Adenyl nucleotide binding", "Adenyl nucleotide exchange factor activity", "Adenylate cyclase binding", "Adenylate kinase activity", "Adenylyltransferase activity", "Adp binding", "Adp ribose diphosphatase activity", "Adp transmembrane transporter activity", "Adrenergic receptor binding", "Alanine transmembrane transporter activity", "Alcohol binding", "Alcohol dehydrogenase activity zinc dependent", "Alcohol dehydrogenase nad p plus activity", "Alcohol dehydrogenase nadpplus activity", "Aldehyde dehydrogenase nad p plus activity", "Aldehyde lyase activity", "Alditol nadpplus 1 oxidoreductase activity", "Aldo keto reductase nadp activity", "Alkali metal ion binding", "Alpha actinin binding", "Alpha catenin binding", "Alpha glucosidase activity", "Alpha tubulin binding", "Amide binding", "Amide transmembrane transporter activity", "Amidine lyase activity", "Amino acid binding", "Amino acid cation symporter activity", "Amino acid proton symporter activity", "Amino acid sodium symporter activity", "Amino acid transmembrane transporter activity", "Aminoacyl trna editing activity", "Aminoacylase activity", "Aminoacyltransferase activity", "Aminopeptidase activity", "Aminophospholipid flippase activity", "Amp activated protein kinase activity", "Amp binding", "Amyloid beta binding", "Anaphase promoting complex binding", "Androgen receptor binding", "Androstan 3 alpha 17 beta diol dehydrogenase activity", "Anion cation symporter activity", "Anion channel activity", "Anion transmembrane transporter activity", "Ankyrin binding", "Ankyrin repeat binding", "Annealing activity", "Antigen binding", "Antioxidant activity", "Antiporter activity", "Apolipoprotein a i binding", "Apolipoprotein binding", "Apolipoprotein receptor binding", "Arachidonate coa ligase activity", "Arginine binding", "Armadillo repeat domain binding", "Aromatic amino acid transmembrane transporter activity", "Arp2 3 complex binding", "Arrestin family protein binding", "Aryl hydrocarbon receptor binding", "Arylesterase activity", "Arylsulfatase activity", "Aspartic endopeptidase activity intramembrane cleaving", "Aspartic type endopeptidase inhibitor activity", "Aspartic type peptidase activity", "Atp dependent activity", "Atp dependent activity acting on dna", "Atp dependent activity acting on rna", "Atp dependent chromatin remodeler activity", "Atp dependent dna dna annealing activity", "Atp dependent peptidase activity", "Atp dependent protein binding", "Atp hydrolysis activity", "Atp transmembrane transporter activity", "Atpase activator activity", "Atpase binding", "Atpase coupled cation transmembrane transporter activity", "Atpase coupled inorganic anion transmembrane transporter activity", "Atpase coupled intramembrane lipid transporter activity", "Atpase coupled ion transmembrane transporter activity", "Atpase coupled lipid transmembrane transporter activity", "Atpase coupled transmembrane transporter activity", "Atpase inhibitor activity", "Atpase regulator activity", "Axon guidance receptor activity", "Azole transmembrane transporter activity", "Basal transcription machinery binding", "Benzodiazepine receptor activity", "Beta 1 3 galactosyltransferase activity", "Beta 2 adrenergic receptor binding", "Beta 2 microglobulin binding", "Beta catenin binding", "Beta galactosidase activity", "Beta n acetylhexosaminidase activity", "Beta tubulin binding", "Bh domain binding", "Bh3 domain binding", "Bhlh transcription factor binding", "Bicarbonate transmembrane transporter activity", "Bile acid binding", "Bioactive lipid receptor activity", "Biotin binding", "Box h aca snorna binding", "Branched chain amino acid transmembrane transporter activity", "Bubble dna binding", "C acetyltransferase activity", "C acyltransferase activity", "C methyltransferase activity", "C palmitoyltransferase activity", "C x c chemokine binding", "C x3 c chemokine binding", "C2h2 zinc finger domain binding", "C3hc4 type ring finger domain binding", "C4 dicarboxylate transmembrane transporter activity", "Cadherin binding", "Cadherin binding involved in cell cell adhesion", "Calcium activated cation channel activity", "Calcium cation antiporter activity", "Calcium channel inhibitor activity", "Calcium channel regulator activity", "Calcium dependent cysteine type endopeptidase activity", "Calcium dependent phospholipid binding", "Calcium dependent protein binding", "Calcium dependent protein kinase activity", "Calcium dependent protein serine threonine phosphatase activity", "Calcium independent phospholipase a2 activity", "Calcium ion binding", "Calcium ion transmembrane transporter activity", "Calmodulin binding", "Calmodulin dependent protein kinase activity", "Calmodulin dependent protein phosphatase activity", "Camp binding", "Camp dependent protein kinase activity", "Camp dependent protein kinase inhibitor activity", "Camp dependent protein kinase regulator activity", "Carbohydrate binding", "Carbohydrate derivative transmembrane transporter activity", "Carbohydrate kinase activity", "Carbohydrate phosphatase activity", "Carbon carbon lyase activity", "Carbon nitrogen ligase activity with glutamine as amido n donor", "Carbon nitrogen lyase activity", "Carbon oxygen lyase activity", "Carbon sulfur lyase activity", "Carbonyl reductase nadph activity", "Carboxy lyase activity", "Carboxylic acid binding", "Carboxylic ester hydrolase activity", "Carboxypeptidase activity", "Card domain binding", "Cardiolipin binding", "Cargo adaptor activity", "Cargo receptor activity", "Carnitine o acyltransferase activity", "Catalytic activity acting on a glycoprotein", "Catalytic activity acting on a nucleic acid", "Catalytic activity acting on a rrna", "Catalytic activity acting on a trna", "Catalytic activity acting on dna", "Catalytic activity acting on rna", "Cation cation antiporter activity", "Cation channel activity", "Cation chloride symporter activity", "Cation transmembrane transporter activity", "Ccr chemokine receptor binding", "Ccr3 chemokine receptor binding", "Ccr5 chemokine receptor binding", "Cdp alcohol phosphatidyltransferase activity", "Cell adhesion mediator activity", "Cell adhesion molecule binding", "Cell adhesive protein binding involved in bundle of his cell purkinje myocyte communication", "Cell cell adhesion mediator activity", "Cell matrix adhesion mediator activity", "Centromeric dna binding", "Ceramide binding", "Cgmp binding", "Channel inhibitor activity", "Channel regulator activity", "Chaperone binding", "Chemoattractant activity", "Chemokine binding", "Chemokine receptor binding", "Chemorepellent activity", "Chitin binding", "Chloride channel inhibitor activity", "Chloride channel regulator activity", "Chloride ion binding", "Chloride transmembrane transporter activity", "Cholesterol binding", "Chondroitin sulfate binding", "Chromatin binding", "Chromatin dna binding", "Chromatin insulator sequence binding", "Chromo shadow domain binding", "Cis regulatory region sequence specific dna binding", "Cis trans isomerase activity", "Class i dna apurinic or apyrimidinic site endonuclease activity", "Clathrin binding", "Clathrin heavy chain binding", "Clathrin light chain binding", "Co smad binding", "Coa hydrolase activity", "Coa transferase activity", "Cobalamin binding", "Collagen binding", "Collagen binding involved in cell matrix adhesion", "Complement binding", "Complement component c1q complex binding", "Complement component c3b binding", "Copper chaperone activity", "Copper ion binding", "Copper ion transmembrane transporter activity", "Core promoter sequence specific dna binding", "Coreceptor activity", "Coreceptor activity involved in wnt signaling pathway", "Coreceptor activity involved in wnt signaling pathway planar cell polarity pathway", "Cullin family protein binding", "Cuprous ion binding", "Cxcr chemokine receptor binding", "Cyclase regulator activity", "Cyclic nucleotide binding", "Cyclic nucleotide dependent protein kinase activity", "Cyclic nucleotide phosphodiesterase activity", "Cyclin binding", "Cyclin dependent protein kinase activity", "Cyclin dependent protein serine threonine kinase activator activity", "Cyclin dependent protein serine threonine kinase inhibitor activity", "Cyclin dependent protein serine threonine kinase regulator activity", "Cyclohydrolase activity", "Cyclosporin a binding", "Cysteine type endopeptidase activity", "Cysteine type endopeptidase inhibitor activity", "Cysteine type endopeptidase inhibitor activity involved in apoptotic process", "Cysteine type endopeptidase regulator activity involved in apoptotic process", "Cysteine type exopeptidase activity", "Cysteine type peptidase activity", "Cytidylyltransferase activity", "Cytochrome b5 reductase activity acting on nad p h", "Cytokine activity", "Cytokine binding", "Cytokine receptor binding", "Cytoskeletal anchor activity", "Cytoskeletal motor activity", "Cytoskeletal protein binding", "Cytoskeleton nuclear membrane anchor activity", "D threo aldose 1 dehydrogenase activity", "D1 dopamine receptor binding", "Damaged dna binding", "Deacetylase activity", "Dead h box rna helicase binding", "Deaminase activity", "Death domain binding", "Death receptor activity", "Demethylase activity", "Deoxynucleoside kinase activity", "Deoxyribonuclease activity", "Diacylglycerol binding", "Diacylglycerol kinase activity", "Dicarboxylic acid transmembrane transporter activity", "Dihydropyrimidinase activity", "Dioxygenase activity", "Dipeptidase activity", "Dipeptidyl peptidase activity", "Diphosphotransferase activity", "Disordered domain specific binding", "Disulfide oxidoreductase activity", "Dna apurinic or apyrimidinic site endonuclease activity", "Dna binding bending", "Dna binding transcription activator activity", "Dna binding transcription factor activity", "Dna binding transcription factor binding", "Dna binding transcription repressor activity", "Dna clamp loader activity", "Dna directed dna polymerase activity", "Dna dna annealing activity", "Dna helicase activity", "Dna insertion or deletion binding", "Dna methyltransferase activity", "Dna n glycosylase activity", "Dna polymerase activity", "Dna polymerase binding", "Dna replication origin binding", "Dna secondary structure binding", "Dna topoisomerase activity", "Dna translocase activity", "Dolichyl diphosphooligosaccharide protein glycotransferase activity", "Dolichyl phosphate mannose protein mannosyltransferase activity", "Dopamine receptor binding", "Double stranded methylated dna binding", "Double stranded rna adenosine deaminase activity", "Double stranded rna binding", "Double stranded telomeric dna binding", "Dttp diphosphatase activity", "Dynactin binding", "Dynein complex binding", "Dynein heavy chain binding", "Dynein intermediate chain binding", "Dynein light chain binding", "Dynein light intermediate chain binding", "Dystroglycan binding", "E box binding", "Efflux transmembrane transporter activity", "Electron transfer activity", "Endodeoxyribonuclease activity", "Endodeoxyribonuclease activity producing 5 phosphomonoesters", "Endonuclease activity", "Endonuclease activity active with either ribo or deoxyribonucleic acids and producing 3 phosphomonoesters", "Endonuclease activity active with either ribo or deoxyribonucleic acids and producing 5 phosphomonoesters", "Endopeptidase activator activity", "Endopeptidase activity", "Endopeptidase regulator activity", "Endopolyphosphatase activity", "Endoribonuclease activity", "Endoribonuclease activity producing 3 phosphomonoesters", "Endoribonuclease activity producing 5 phosphomonoesters", "Enoyl coa hydratase activity", "Enzyme activator activity", "Enzyme inhibitor activity", "Enzyme regulator activity", "Ephrin receptor activity", "Ephrin receptor binding", "Epidermal growth factor receptor binding", "Epoxide hydrolase activity", "Er retention sequence binding", "Erbb 3 class receptor binding", "Estradiol 17 beta dehydrogenase activity", "Estrogen receptor binding", "Ether hydrolase activity", "Eukaryotic initiation factor 4e binding", "Exodeoxyribonuclease activity", "Exogenous protein binding", "Exonuclease activity", "Exonuclease activity active with either ribo or deoxyribonucleic acids and producing 5 phosphomonoesters", "Exopeptidase activity", "Exoribonuclease activity", "Exoribonuclease activity producing 5 phosphomonoesters", "Extracellular matrix binding", "Fad binding", "Fatty acid binding", "Fatty acid derivative binding", "Fatty acid ligase activity", "Fatty acid synthase activity", "Fatty acid transmembrane transporter activity", "Ferric iron binding", "Ferrous iron binding", "Fibroblast growth factor binding", "Fibronectin binding", "Fk506 binding", "Flap endonuclease activity", "Flavin adenine dinucleotide binding", "Flippase activity", "Floppase activity", "Fmn binding", "Folic acid binding", "Folic acid transmembrane transporter activity", "Four way junction dna binding", "Four way junction helicase activity", "Frizzled binding", "Fructose 2 6 bisphosphate 2 phosphatase activity", "Fructose 6 phosphate binding", "Fructose binding", "Fucosyltransferase activity", "G protein activity", "G protein alpha subunit binding", "G protein beta gamma subunit complex binding", "G protein beta subunit binding", "G protein coupled glutamate receptor binding", "G protein coupled opioid receptor activity", "G protein coupled receptor activity", "G protein coupled receptor binding", "G protein coupled serotonin receptor binding", "G quadruplex dna binding", "G quadruplex rna binding", "G rich strand telomeric dna binding", "Gaba receptor binding", "Galactosidase activity", "Galactoside binding", "Galactosyltransferase activity", "Gamma aminobutyric acid transmembrane transporter activity", "Gamma catenin binding", "Gamma tubulin binding", "Ganglioside binding", "Gated channel activity", "Gdp binding", "Gdp dissociation inhibitor activity", "General transcription initiation factor activity", "General transcription initiation factor binding", "Glucocorticoid receptor binding", "Glucose binding", "Glucosidase activity", "Glucosyltransferase activity", "Glucuronosyltransferase activity", "Glutamate binding", "Glutamate receptor binding", "Glutathione disulfide oxidoreductase activity", "Glutathione oxidoreductase activity", "Glutathione peroxidase activity", "Glutathione transferase activity", "Glutathione transmembrane transporter activity", "Glyceraldehyde 3 phosphate dehydrogenase nadplus non phosphorylating activity", "Glycerophospholipid flippase activity", "Glycine binding", "Glycolipid binding", "Glycolipid mannosyltransferase activity", "Glycosaminoglycan binding", "Glycosphingolipid binding", "Glycosyltransferase activity", "Gpi anchor binding", "Gpi linked ephrin receptor activity", "Growth factor activity", "Growth factor binding", "Growth factor receptor binding", "Gtp dependent protein binding", "Gtpase activating protein binding", "Gtpase activator activity", "Gtpase activity", "Gtpase binding", "Gtpase inhibitor activity", "Guanyl nucleotide binding", "Guanyl nucleotide exchange factor activity", "Guanylate kinase activity", "Guanylyltransferase activity", "H4 histone acetyltransferase activity", "Heat shock protein binding", "Helicase activity", "Heme transmembrane transporter activity", "Heparan sulfate proteoglycan binding", "Heparan sulfate sulfotransferase activity", "Heparin binding", "Hexokinase activity", "Hexosaminidase activity", "Hexosyltransferase activity", "High density lipoprotein particle binding", "Histone acetyltransferase binding", "Histone arginine n methyltransferase activity", "Histone binding", "Histone deacetylase activity h3 k14 specific", "Histone deacetylase binding", "Histone deacetylase regulator activity", "Histone h3 di monomethyl lysine 9 demethylase activity", "Histone h3 methyl lysine 36 demethylase activity", "Histone h3 methyl lysine 4 demethylase activity", "Histone h3 methyl lysine 9 demethylase activity", "Histone kinase activity", "Histone lysine n methyltransferase activity", "Histone methyltransferase activity", "Histone methyltransferase activity h3 k36 specific", "Histone methyltransferase activity h3 k4 specific", "Histone methyltransferase activity h4 k20 specific", "Histone methyltransferase binding", "Histone serine kinase activity", "Histone threonine kinase activity", "Hormone activity", "Hormone binding", "Hormone receptor binding", "Hsp70 protein binding", "Hsp90 protein binding", "Hyaluronic acid binding", "Hyalurononglucosaminidase activity", "Hydro lyase activity", "Hydrolase activity acting on acid anhydrides", "Hydrolase activity acting on carbon nitrogen but not peptide bonds", "Hydrolase activity acting on carbon nitrogen but not peptide bonds in cyclic amides", "Hydrolase activity acting on carbon nitrogen but not peptide bonds in cyclic amidines", "Hydrolase activity acting on carbon nitrogen but not peptide bonds in linear amides", "Hydrolase activity acting on carbon nitrogen but not peptide bonds in linear amidines", "Hydrolase activity acting on ester bonds", "Hydrolase activity acting on ether bonds", "Hydrolase activity acting on glycosyl bonds", "Hydrolase activity hydrolyzing n glycosyl compounds", "Hydrolase activity hydrolyzing o glycosyl compounds", "Hydroxymethyl formyl and related transferase activity", "I smad binding", "Icosanoid binding", "Identical protein binding", "Igg binding", "Immunoglobulin binding", "Immunoglobulin receptor binding", "Importin alpha family protein binding", "Inorganic anion exchanger activity", "Inorganic anion transmembrane transporter activity", "Inorganic diphosphatase activity", "Inorganic molecular entity transmembrane transporter activity", "Inorganic phosphate transmembrane transporter activity", "Inositol 1 4 5 trisphosphate 5 phosphatase activity", "Inositol phosphate phosphatase activity", "Inositol polyphosphate 5 phosphatase activity", "Inositol tetrakisphosphate phosphatase activity", "Inositol trisphosphate phosphatase activity", "Insulin binding", "Insulin like growth factor binding", "Insulin like growth factor ii binding", "Insulin like growth factor receptor binding", "Insulin receptor binding", "Insulin receptor substrate binding", "Integrin binding", "Interleukin 1 receptor binding", "Interleukin 2 receptor binding", "Interleukin 6 receptor binding", "Intermediate filament binding", "Intracellular calcium activated chloride channel activity", "Intraciliary transport particle b binding", "Intramembrane lipid transporter activity", "Intramolecular oxidoreductase activity", "Intramolecular oxidoreductase activity interconverting aldoses and ketoses", "Intramolecular oxidoreductase activity transposing c c bonds", "Intramolecular transferase activity", "Intramolecular transferase activity phosphotransferases", "Intronic transcription regulatory region sequence specific dna binding", "Ion gated channel activity", "Ion transmembrane transporter activity", "Ionotropic glutamate receptor binding", "Iron ion binding", "Iron ion transmembrane transporter activity", "Isocitrate dehydrogenase activity", "Isomerase activity", "Isopeptidase activity", "Isoprenoid binding", "Jun kinase binding", "K48 linked polyubiquitin modification dependent protein binding", "K63 linked polyubiquitin modification dependent protein binding", "Keratin filament binding", "Kinase activator activity", "Kinase activity", "Kinase binding", "Kinase inhibitor activity", "Kinase regulator activity", "Kinesin binding", "Kinetochore binding", "L alanine transmembrane transporter activity", "L amino acid transmembrane transporter activity", "L ascorbic acid binding", "L aspartate transmembrane transporter activity", "L glutamine transmembrane transporter activity", "L lactate dehydrogenase activity", "L leucine transmembrane transporter activity", "L ornithine transmembrane transporter activity", "L serine transmembrane transporter activity", "Lactate dehydrogenase activity", "Lactate transmembrane transporter activity", "Lamin binding", "Laminin 1 binding", "Laminin binding", "Large ribosomal subunit rrna binding", "Leucine binding", "Leucine zipper domain binding", "Leukotriene c4 synthase activity", "Ligand gated ion channel activity", "Ligase activity", "Ligase activity forming carbon carbon bonds", "Ligase activity forming carbon nitrogen bonds", "Ligase activity forming carbon oxygen bonds", "Ligase activity forming carbon sulfur bonds", "Ligase activity forming phosphoric ester bonds", "Lim domain binding", "Lipase activator activity", "Lipase activity", "Lipase binding", "Lipase inhibitor activity", "Lipid binding", "Lipid kinase activity", "Lipid phosphatase activity", "Lipid transfer activity", "Lipid transporter activity", "Lipopolysaccharide binding", "Lipopolysaccharide immune receptor activity", "Lipoprotein particle receptor activity", "Lipoprotein particle receptor binding", "Long chain acyl coa dehydrogenase activity", "Long chain fatty acid binding", "Long chain fatty acid coa ligase activity", "Long chain fatty acid transporter activity", "Long chain fatty acyl coa binding", "Low density lipoprotein particle binding", "Low density lipoprotein particle receptor activity", "Low density lipoprotein particle receptor binding", "Lrr domain binding", "Lyase activity", "Lys48 specific deubiquitinase activity", "Lys63 specific deubiquitinase activity", "Lysine acetylated histone binding", "Lysine n methyltransferase activity", "Lysophosphatidic acid binding", "Lysophosphatidic acid phosphatase activity", "Lysophospholipase activity", "Lysophospholipid acyltransferase activity", "M7g 5 pppn diphosphatase activity", "Macrolide binding", "Macromolecule transmembrane transporter activity", "Magnesium ion binding", "Magnesium ion transmembrane transporter activity", "Malate dehydrogenase activity", "Manganese ion binding", "Manganese ion transmembrane transporter activity", "Mannose binding", "Mannosidase activity", "Mannosyl oligosaccharide 1 2 alpha mannosidase activity", "Mannosyl oligosaccharide mannosidase activity", "Mannosyltransferase activity", "Map kinase activity", "Map kinase kinase activity", "Map kinase kinase kinase activity", "Map kinase phosphatase activity", "Map kinase scaffold activity", "Map kinase tyrosine serine threonine phosphatase activity", "Mdm2 mdm4 family protein binding", "Medium chain fatty acid coa ligase activity", "Membrane insertase activity", "Metal cluster binding", "Metal dependent deubiquitinase activity", "Metal ion proton antiporter activity", "Metal ion transmembrane transporter activity", "Metalloaminopeptidase activity", "Metallocarboxypeptidase activity", "Metallochaperone activity", "Metallodipeptidase activity", "Metalloendopeptidase activity", "Metalloexopeptidase activity", "Metallopeptidase activity", "Methyl cpg binding", "Methylated histone binding", "Mhc class i protein binding", "Mhc class ib protein binding", "Mhc class ii protein complex binding", "Mhc protein binding", "Mhc protein complex binding", "Microfilament motor activity", "Microtubule binding", "Microtubule minus end binding", "Microtubule motor activity", "Microtubule plus end binding", "Minor groove of adenine thymine rich dna binding", "Minus end directed microtubule motor activity", "Mirna binding", "Misfolded protein binding", "Mismatch repair complex binding", "Mismatched dna binding", "Mitochondrial ribosome binding", "Mitochondrion targeting sequence binding", "Mitogen activated protein kinase binding", "Mitogen activated protein kinase kinase kinase binding", "Mitogen activated protein kinase p38 binding", "Modification dependent protein binding", "Modified amino acid binding", "Modified amino acid transmembrane transporter activity", "Molecular adaptor activity", "Molecular carrier activity", "Molecular function activator activity", "Molecular function inhibitor activity", "Molecular function regulator", "Molecular sequestering activity", "Molecular transducer activity", "Molybdopterin cofactor binding", "Monocarboxylic acid binding", "Monocarboxylic acid transmembrane transporter activity", "Monooxygenase activity", "Monosaccharide binding", "Mrf binding", "Mrna 3 utr au rich region binding", "Mrna 3 utr binding", "Mrna 5 utr binding", "Mrna binding", "Mrna methyltransferase activity", "Muscle alpha actinin binding", "Mutlalpha complex binding", "Myosin binding", "Myosin ii binding", "Myosin v binding", "Myristoyltransferase activity", "N acetylgalactosamine 4 o sulfotransferase activity", "N acetyllactosaminide beta 1 3 n acetylglucosaminyltransferase activity", "N acetyltransferase activity", "N acylsphingosine amidohydrolase activity", "N acyltransferase activity", "N methyltransferase activity", "N6 methyladenosine containing rna binding", "Nad binding", "Nad dependent protein deacetylase activity", "Nad p h oxidase h2o2 forming activity", "Nad p plus nucleosidase activity", "Nad p plus protein arginine adp ribosyltransferase activity", "Nad retinol dehydrogenase activity", "Nadh dehydrogenase activity", "Nadh pyrophosphatase activity", "Nadp binding", "Nadp retinol dehydrogenase activity", "Nadph binding", "Nadplus adp ribosyltransferase activity", "Nadplus binding", "Nadplus kinase activity", "Nadplus nucleosidase activity", "Nedd8 specific protease activity", "Nedd8 transferase activity", "Neurexin family protein binding", "Neuropeptide hormone activity", "Neuropeptide receptor activity", "Neuropeptide receptor binding", "Neurotransmitter binding", "Neurotransmitter receptor activity", "Neurotransmitter receptor regulator activity", "Neurotransmitter transmembrane transporter activity", "Neurotrophin binding", "Neurotrophin receptor binding", "Neurotrophin trk receptor binding", "Neutral amino acid transmembrane transporter activity", "Nf kappab binding", "Nf kappab inducing kinase activity", "Nfat protein binding", "Nitric oxide synthase binding", "Nitric oxide synthase regulator activity", "Nitrite reductase activity", "Non membrane spanning protein tyrosine kinase activity", "Non membrane spanning protein tyrosine phosphatase activity", "Notch binding", "Nuclear export signal receptor activity", "Nuclear import signal receptor activity", "Nuclear localization sequence binding", "Nuclear receptor activity", "Nuclear receptor binding", "Nuclear receptor coactivator activity", "Nuclease activity", "Nucleobase containing compound kinase activity", "Nucleobase containing compound transmembrane transporter activity", "Nucleobase transmembrane transporter activity", "Nucleocytoplasmic carrier activity", "Nucleoside binding", "Nucleoside diphosphatase activity", "Nucleoside diphosphate kinase activity", "Nucleoside kinase activity", "Nucleoside monophosphate kinase activity", "Nucleoside triphosphatase regulator activity", "Nucleoside triphosphate diphosphatase activity", "Nucleosomal dna binding", "Nucleosome binding", "Nucleotidase activity", "Nucleotide diphosphatase activity", "Nucleotide phosphatase activity acting on free nucleotides", "Nucleotide sugar transmembrane transporter activity", "Nucleotide transmembrane transporter activity", "Nucleotidyltransferase activity", "O acetyltransferase activity", "O acyltransferase activity", "O methyltransferase activity", "O palmitoyltransferase activity", "Oleate transmembrane transporter activity", "Oligopeptide binding", "Oligopeptide transmembrane transporter activity", "Oligosaccharide binding", "Oligosaccharyl transferase activity", "Omega peptidase activity", "Opsonin binding", "Organic acid binding", "Organic acid sodium symporter activity", "Organic acid transmembrane transporter activity", "Organic anion transmembrane transporter activity", "Organic cation transmembrane transporter activity", "Organic hydroxy compound transmembrane transporter activity", "Organophosphate ester transmembrane transporter activity", "Oxidative phosphorylation uncoupler activity", "Oxidative rna demethylase activity", "Oxidized dna binding", "Oxidoreductase activity", "Oxidoreductase activity acting on a heme group of donors", "Oxidoreductase activity acting on a sulfur group of donors", "Oxidoreductase activity acting on a sulfur group of donors disulfide as acceptor", "Oxidoreductase activity acting on a sulfur group of donors nad p as acceptor", "Oxidoreductase activity acting on a sulfur group of donors oxygen as acceptor", "Oxidoreductase activity acting on ch oh group of donors", "Oxidoreductase activity acting on ch or ch2 groups", "Oxidoreductase activity acting on diphenols and related substances as donors", "Oxidoreductase activity acting on nad p h", "Oxidoreductase activity acting on nad p h heme protein as acceptor", "Oxidoreductase activity acting on nad p h oxygen as acceptor", "Oxidoreductase activity acting on nad p h quinone or similar compound as acceptor", "Oxidoreductase activity acting on other nitrogenous compounds as donors", "Oxidoreductase activity acting on other nitrogenous compounds as donors cytochrome as acceptor", "Oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen", "Oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen nad p h as one donor and incorporation of one atom of oxygen", "Oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen reduced flavin or flavoprotein as one donor and incorporation of one atom of oxygen", "Oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen reduced pteridine as one donor and incorporation of one atom of oxygen", "Oxidoreductase activity acting on paired donors with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water", "Oxidoreductase activity acting on peroxide as acceptor", "Oxidoreductase activity acting on single donors with incorporation of molecular oxygen", "Oxidoreductase activity acting on the aldehyde or oxo group of donors", "Oxidoreductase activity acting on the aldehyde or oxo group of donors disulfide as acceptor", "Oxidoreductase activity acting on the aldehyde or oxo group of donors nad or nadp as acceptor", "Oxidoreductase activity acting on the ch ch group of donors", "Oxidoreductase activity acting on the ch ch group of donors nad or nadp as acceptor", "Oxidoreductase activity acting on the ch ch group of donors oxygen as acceptor", "Oxidoreductase activity acting on the ch nh group of donors", "Oxidoreductase activity acting on the ch nh group of donors nad or nadp as acceptor", "Oxidoreductase activity acting on the ch nh2 group of donors", "Oxidoreduction driven active transmembrane transporter activity", "Oxo acid lyase activity", "Oxygen binding", "Oxygen sensor activity", "Oxysterol binding", "P type calcium transporter activity", "P type potassium transmembrane transporter activity", "P type transmembrane transporter activity", "P53 binding", "Palmitoyl coa hydrolase activity", "Palmitoyl protein hydrolase activity", "Palmitoyltransferase activity", "Passive transmembrane transporter activity", "Patched binding", "Pattern recognition receptor activity", "Pdz domain binding", "Pentosyltransferase activity", "Peptidase activator activity", "Peptidase activator activity involved in apoptotic process", "Peptidase activity", "Peptidase regulator activity", "Peptide alpha n acetyltransferase activity", "Peptide antigen binding", "Peptide binding", "Peptide hormone binding", "Peptide hormone receptor binding", "Peptide lysine n acetyltransferase activity", "Peptide n acetyltransferase activity", "Peptide receptor activity", "Peptide transmembrane transporter activity", "Peptidoglycan binding", "Peptidyl proline 4 dioxygenase activity", "Peptidyl proline dioxygenase activity", "Peroxiredoxin activity", "Peroxisome proliferator activated receptor binding", "Peroxisome targeting sequence binding", "Phosphatase activator activity", "Phosphatase activity", "Phosphatase binding", "Phosphatase inhibitor activity", "Phosphatase regulator activity", "Phosphate ion binding", "Phosphatidic acid binding", "Phosphatidyl phospholipase b activity", "Phosphatidylcholine binding", "Phosphatidylcholine floppase activity", "Phosphatidylcholine transfer activity", "Phosphatidylcholine transporter activity", "Phosphatidylethanolamine binding", "Phosphatidylethanolamine flippase activity", "Phosphatidylglycerol binding", "Phosphatidylinositol 3 4 5 trisphosphate 3 phosphatase activity", "Phosphatidylinositol 3 4 5 trisphosphate 5 phosphatase activity", "Phosphatidylinositol 3 4 5 trisphosphate binding", "Phosphatidylinositol 3 4 bisphosphate binding", "Phosphatidylinositol 3 5 bisphosphate 3 phosphatase activity", "Phosphatidylinositol 3 5 bisphosphate 5 phosphatase activity", "Phosphatidylinositol 3 5 bisphosphate binding", "Phosphatidylinositol 3 5 bisphosphate phosphatase activity", "Phosphatidylinositol 3 kinase binding", "Phosphatidylinositol 3 kinase regulatory subunit binding", "Phosphatidylinositol 3 phosphate binding", "Phosphatidylinositol 4 5 bisphosphate 5 phosphatase activity", "Phosphatidylinositol 4 5 bisphosphate binding", "Phosphatidylinositol 4 5 bisphosphate phosphatase activity", "Phosphatidylinositol 4 phosphate binding", "Phosphatidylinositol 5 phosphate binding", "Phosphatidylinositol binding", "Phosphatidylinositol bisphosphate binding", "Phosphatidylinositol bisphosphate phosphatase activity", "Phosphatidylinositol kinase activity", "Phosphatidylinositol monophosphate phosphatase activity", "Phosphatidylinositol phosphate 4 phosphatase activity", "Phosphatidylinositol phosphate 5 phosphatase activity", "Phosphatidylinositol phosphate binding", "Phosphatidylinositol phosphate kinase activity", "Phosphatidylinositol phosphate phosphatase activity", "Phosphatidylinositol transfer activity", "Phosphatidylinositol trisphosphate phosphatase activity", "Phosphatidylserine 1 acylhydrolase activity", "Phosphatidylserine binding", "Phosphodiesterase i activity", "Phosphofructokinase activity", "Phospholipase a1 activity", "Phospholipase a2 activity", "Phospholipase a2 inhibitor activity", "Phospholipase activity", "Phospholipase binding", "Phospholipase c activity", "Phospholipase d activity", "Phospholipase inhibitor activity", "Phospholipid binding", "Phospholipid scramblase activity", "Phospholipid transfer activity", "Phospholipid transporter activity", "Phosphoprotein binding", "Phosphoprotein phosphatase activity", "Phosphoric diester hydrolase activity", "Phosphoric ester hydrolase activity", "Phosphorus oxygen lyase activity", "Phosphoserine residue binding", "Phosphotransferase activity for other substituted phosphate groups", "Phosphotransferase activity nitrogenous group as acceptor", "Phosphotransferase activity phosphate group as acceptor", "Phosphotyrosine residue binding", "Plus end directed microtubule motor activity", "Poly a binding", "Poly a specific ribonuclease activity", "Poly g binding", "Poly purine tract binding", "Poly pyrimidine tract binding", "Polynucleotide adenylyltransferase activity", "Polypeptide n acetylgalactosaminyltransferase activity", "Polysaccharide binding", "Polysome binding", "Polyubiquitin modification dependent protein binding", "Porin activity", "Potassium channel activity", "Potassium channel regulator activity", "Potassium chloride symporter activity", "Potassium ion binding", "Potassium ion transmembrane transporter activity", "Pre mirna binding", "Pre mrna 3 splice site binding", "Pre mrna 5 splice site binding", "Pre mrna binding", "Pre mrna intronic binding", "Prenyltransferase activity", "Primary active transmembrane transporter activity", "Primary mirna binding", "Procollagen proline 4 dioxygenase activity", "Procollagen proline dioxygenase activity", "Profilin binding", "Proline rich region binding", "Promoter specific chromatin binding", "Protease binding", "Proteasome activating activity", "Proteasome binding", "Protein adp ribosylase activity", "Protein antigen binding", "Protein arginine n methyltransferase activity", "Protein arginine omega n asymmetric methyltransferase activity", "Protein arginine omega n monomethyltransferase activity", "Protein binding involved in heterotypic cell cell adhesion", "Protein c terminus binding", "Protein carboxyl o methyltransferase activity", "Protein carrier chaperone", "Protein containing complex binding", "Protein deacetylase activity", "Protein demethylase activity", "Protein dimerization activity", "Protein disaggregase activity", "Protein disulfide isomerase activity", "Protein disulfide reductase nad p activity", "Protein domain specific binding", "Protein folding chaperone", "Protein geranylgeranyltransferase activity", "Protein heterodimerization activity", "Protein homodimerization activity", "Protein kinase a binding", "Protein kinase a catalytic subunit binding", "Protein kinase a regulatory subunit binding", "Protein kinase activity", "Protein kinase b binding", "Protein kinase c activity", "Protein kinase c binding", "Protein lipid complex binding", "Protein macromolecule adaptor activity", "Protein membrane adaptor activity", "Protein methyltransferase activity", "Protein n terminus binding", "Protein phosphatase 1 binding", "Protein phosphatase 2a binding", "Protein phosphatase activator activity", "Protein phosphatase binding", "Protein phosphatase regulator activity", "Protein phosphorylated amino acid binding", "Protein prenyltransferase activity", "Protein self association", "Protein sequestering activity", "Protein serine kinase activity", "Protein serine threonine kinase activator activity", "Protein serine threonine kinase activity", "Protein serine threonine kinase inhibitor activity", "Protein serine threonine phosphatase activity", "Protein serine threonine phosphatase inhibitor activity", "Protein serine threonine tyrosine kinase activity", "Protein transmembrane transporter activity", "Protein transporter activity", "Protein tyrosine kinase activator activity", "Protein tyrosine kinase activity", "Protein tyrosine kinase binding", "Protein tyrosine kinase inhibitor activity", "Protein tyrosine phosphatase activity", "Protein tyrosine serine threonine phosphatase activity", "Protein tyrosine threonine phosphatase activity", "Proteoglycan binding", "Proton channel activity", "Proton transmembrane transporter activity", "Proton transporting atp synthase activity rotational mechanism", "Pseudouridine synthase activity", "Purine nucleotide transmembrane transporter activity", "Pyrimidine nucleotide binding", "Pyrimidine nucleotide sugar transmembrane transporter activity", "Pyrophosphate hydrolysis driven proton transmembrane transporter activity", "Pyruvate dehydrogenase acetyl transferring kinase activity", "Pyruvate dehydrogenase activity", "Pyruvate transmembrane transporter activity", "Quaternary ammonium group binding", "Quaternary ammonium group transmembrane transporter activity", "Quinone binding", "R smad binding", "Racemase and epimerase activity", "Rage receptor binding", "Rdna binding", "Receptor antagonist activity", "Receptor tyrosine kinase binding", "Regulatory rna binding", "Retinal binding", "Retinal dehydrogenase activity", "Retinoic acid binding", "Retinoic acid receptor binding", "Retinoid x receptor binding", "Retinol binding", "Retromer complex binding", "Ribonuclease activity", "Ribonuclease p activity", "Ribonuclease p rna binding", "Ribonucleoprotein complex binding", "Ribonucleotide binding", "Ribose phosphate diphosphokinase activity", "Ribosomal large subunit binding", "Ribosomal protein s6 kinase activity", "Ribosomal small subunit binding", "Ribosome binding", "Rna 2 o methyltransferase activity", "Rna 7 methylguanosine cap binding", "Rna adenylyltransferase activity", "Rna binding", "Rna binding involved in posttranscriptional gene silencing", "Rna cap binding", "Rna directed dna polymerase activity", "Rna dna hybrid ribonuclease activity", "Rna methyltransferase activity", "Rna polymerase activity", "Rna polymerase binding", "Rna polymerase core enzyme binding", "Rna polymerase i general transcription initiation factor activity", "Rna polymerase i transcription regulatory region sequence specific dna binding", "Rna polymerase ii activity", "Rna polymerase ii c terminal domain binding", "Rna polymerase ii c terminal domain phosphoserine binding", "Rna polymerase ii core promoter sequence specific dna binding", "Rna polymerase ii ctd heptapeptide repeat kinase activity", "Rna polymerase ii ctd heptapeptide repeat phosphatase activity", "Rna polymerase ii general transcription initiation factor activity", "Rna polymerase ii general transcription initiation factor binding", "Rna polymerase ii intronic transcription regulatory region sequence specific dna binding", "Rna polymerase ii specific dna binding transcription factor binding", "Rna polymerase iii transcription regulatory region sequence specific dna binding", "Rna stem loop binding", "Rna strand annealing activity", "Roundabout binding", "Rrna adenine methyltransferase activity", "Rrna binding", "Rrna cytosine methyltransferase activity", "S acyltransferase activity", "S adenosyl l methionine binding", "S adenosylmethionine dependent methyltransferase activity", "S methyltransferase activity", "S100 protein binding", "Scaffold protein binding", "Scavenger receptor activity", "Secondary active transmembrane transporter activity", "Semaphorin receptor activity", "Sequence specific dna binding", "Sequence specific mrna binding", "Sequence specific single stranded dna binding", "Serine hydrolase activity", "Serine transmembrane transporter activity", "Serine type carboxypeptidase activity", "Serine type endopeptidase inhibitor activity", "Serine type exopeptidase activity", "Sh2 domain binding", "Sh3 domain binding", "Signal recognition particle binding", "Signal sequence binding", "Signaling adaptor activity", "Signaling receptor binding", "Signaling receptor complex adaptor activity", "Signaling receptor inhibitor activity", "Signaling receptor regulator activity", "Single stranded dna 3 5 exodeoxyribonuclease activity", "Single stranded dna binding", "Single stranded dna endodeoxyribonuclease activity", "Single stranded dna exodeoxyribonuclease activity", "Single stranded dna helicase activity", "Single stranded rna binding", "Single stranded telomeric dna binding", "Sirna binding", "Smad binding", "Small molecule sensor activity", "Small protein activating enzyme binding", "Small ribosomal subunit rrna binding", "Snap receptor activity", "Snare binding", "Snorna binding", "Snrna binding", "Snrnp binding", "Sodium channel inhibitor activity", "Sodium channel regulator activity", "Sodium ion binding", "Sodium ion transmembrane transporter activity", "Solute anion antiporter activity", "Solute bicarbonate symporter activity", "Solute cation antiporter activity", "Solute cation symporter activity", "Solute proton antiporter activity", "Solute proton symporter activity", "Solute sodium symporter activity", "Spectrin binding", "Sphingolipid binding", "Sphingolipid transfer activity", "Sphingolipid transporter activity", "Sphingomyelin phosphodiesterase activity", "Sphingosine 1 phosphate receptor activity", "Sphingosine n acyltransferase activity", "Steroid binding", "Steroid dehydrogenase activity", "Steroid dehydrogenase activity acting on the ch oh group of donors nad or nadp as acceptor", "Steroid hormone binding", "Steroid hormone receptor activity", "Sterol binding", "Sterol esterase activity", "Sterol transfer activity", "Sterol transporter activity", "Structural constituent of cytoskeleton", "Structural constituent of eye lens", "Structural constituent of muscle", "Structural constituent of nuclear pore", "Structural constituent of postsynapse", "Structural constituent of postsynaptic actin cytoskeleton", "Structural constituent of presynaptic active zone", "Structural constituent of ribosome", "Structural constituent of synapse", "Structural molecule activity", "Structural molecule activity conferring elasticity", "Succinate transmembrane transporter activity", "Sulfate binding", "Sulfate transmembrane transporter activity", "Sulfatide binding", "Sulfotransferase activity", "Sulfur compound binding", "Sulfur compound transmembrane transporter activity", "Sulfuric ester hydrolase activity", "Sulfurtransferase activity", "Sumo binding", "Sumo ligase activity", "Sumo specific protease activity", "Sumo transferase activity", "Supercoiled dna binding", "Superoxide dismutase activity", "Symporter activity", "Syndecan binding", "Syntaxin 1 binding", "Syntaxin binding", "T cell receptor binding", "Tap binding", "Tap1 binding", "Tat protein binding", "Tau protein binding", "Tau protein kinase activity", "Tbp class protein binding", "Telomerase activity", "Telomerase inhibitor activity", "Telomerase rna binding", "Telomeric dna binding", "Testosterone dehydrogenase nad p activity", "Testosterone dehydrogenase nadplus activity", "Tetrapyrrole binding", "Tfiib class transcription factor binding", "Tfiid class transcription factor complex binding", "Thiamine pyrophosphate binding", "Thioesterase binding", "Thiol oxidase activity", "Thiolester hydrolase activity", "Thioredoxin disulfide reductase activity", "Threonine type endopeptidase activity", "Threonine type peptidase activity", "Thyroid hormone receptor binding", "Titin binding", "Toxic substance binding", "Tpr domain binding", "Transcription coactivator activity", "Transcription coactivator binding", "Transcription coregulator activity", "Transcription coregulator binding", "Transcription corepressor activity", "Transcription corepressor binding", "Transcription elongation regulator activity", "Transcription factor binding", "Transcription regulator activity", "Transcription regulator inhibitor activity", "Transferase activity transferring alkyl or aryl other than methyl groups", "Transferase activity transferring nitrogenous groups", "Transferase activity transferring one carbon groups", "Transferase activity transferring phosphorus containing groups", "Transferase activity transferring sulphur containing groups", "Transferrin receptor binding", "Transforming growth factor beta receptor binding", "Transition metal ion binding", "Transition metal ion transmembrane transporter activity", "Transketolase or transaldolase activity", "Translation activator activity", "Translation elongation factor activity", "Translation factor activity rna binding", "Translation initiation factor activity", "Translation initiation factor binding", "Translation regulator activity", "Translation regulator activity nucleic acid binding", "Translation repressor activity", "Translation repressor activity mrna regulatory element binding", "Translation termination factor activity", "Transmembrane receptor protein kinase activity", "Transmembrane receptor protein phosphatase activity", "Transmembrane receptor protein tyrosine kinase activity", "Transmembrane transporter binding", "Transporter activity", "Tripeptide transmembrane transporter activity", "Trna binding", "Trna cytosine methyltransferase activity", "Trna guanine methyltransferase activity", "Trna methyltransferase activity", "Trna specific adenosine deaminase activity", "Trna specific ribonuclease activity", "Tropomyosin binding", "Tubulin binding", "Tumor necrosis factor activated receptor activity", "Tumor necrosis factor binding", "Tumor necrosis factor receptor binding", "Tumor necrosis factor receptor superfamily binding", "Type i transforming growth factor beta receptor binding", "U1 snrna binding", "U2 snrna binding", "U3 snorna binding", "U4 snrna binding", "U6 snrna binding", "Ubiquinol cytochrome c reductase activity", "Ubiquinone binding", "Ubiquitin binding", "Ubiquitin conjugating enzyme binding", "Ubiquitin ligase substrate adaptor activity", "Ubiquitin like modifier activating enzyme activity", "Ubiquitin like protein binding", "Ubiquitin like protein conjugating enzyme activity", "Ubiquitin like protein conjugating enzyme binding", "Ubiquitin like protein ligase activity", "Ubiquitin like protein ligase binding", "Ubiquitin like protein specific isopeptidase activity", "Ubiquitin like protein specific protease activity", "Ubiquitin like protein transferase activity", "Ubiquitin protein transferase activator activity", "Ubiquitin protein transferase inhibitor activity", "Ubiquitin protein transferase regulator activity", "Ubiquitin specific protease binding", "Ubiquitin ubiquitin ligase activity", "Ubiquitination like modification dependent protein binding", "Udp galactose beta n acetylglucosamine beta 1 3 galactosyltransferase activity", "Udp glucosyltransferase activity", "Udp glycosyltransferase activity", "Udp xylosyltransferase activity", "Unfolded protein binding", "Unmethylated cpg binding", "Uridylyltransferase activity", "Vascular endothelial growth factor receptor 2 binding", "Vascular endothelial growth factor receptor binding", "Very long chain fatty acid coa ligase activity", "Vinculin binding", "Virion binding", "Vitamin b6 binding", "Vitamin binding", "Vitamin d binding", "Vitamin d receptor binding", "Vitamin transmembrane transporter activity", "Voltage gated anion channel activity", "Voltage gated calcium channel activity", "Voltage gated calcium channel activity involved in regulation of cytosolic calcium levels", "Voltage gated cation channel activity", "Voltage gated channel activity", "Voltage gated chloride channel activity", "Volume sensitive anion channel activity", "Water channel activity", "Water transmembrane transporter activity", "Wd40 repeat domain binding", "Wide pore channel activity", "Wnt protein binding", "Ww domain binding", "Xenobiotic transmembrane transporter activity", "Zinc ion binding", "Zinc ion transmembrane transporter activity"], "available_proteins": ["AAMP", "AARS", "AARS2", "AASDHPPT", "AASS", "AATF", "ABCB1", "ABCB7", "ABCC1", "ABCD3", "ABCE1", "ABCF1", "ABCF2", "ABCF3", "ABHD10", "ABHD12", "ABHD6", "ABI1", "ACAA2", "ACACA", "ACACB", "ACAD11", "ACAD9", "ACADM", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACBD5", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT9", "ACOX1", "ACOX3", "ACP1", "ACP2", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN4", "ACTR1A", "ACTR1B", "ACTR2", "ACTR3", "ADAR", "ADD1", "ADD3", "ADH5", "ADI1", "ADNP", "ADPGK", "ADPRHL2", "ADRM1", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGK", "AGL", "AGPAT1", "AGPAT5", "AGPS", "AHCY", "AHCYL1", "AHNAK", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AKAP12", "AKAP13", "AKAP8", "AKAP8L", "AKR1A1", "AKR1B1", "AKR7A2", "AKT2", "ALDH18A1", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALG1", "ALG11", "ALG12", "ALKBH5", "ALYREF", "AMOT", "ANAPC1", "ANAPC2", "ANAPC5", "ANAPC7", "ANGEL1", "ANKFY1", "ANKHD1", "ANKLE2", "ANKRD17", "ANO10", "ANO6", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA3", "ANXA4", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP1M1", "AP1S2", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3M1", "APEH", "APEX1", "API5", "APLP2", "APMAP", "APOL2", "APP", "APRT", "AQR", "ARAF", "ARCN1", "ARF4", "ARF6", "ARFGAP1", "ARFGAP2", "ARFIP1", "ARFIP2", "ARGLU1", "ARHGAP1", "ARHGAP17", "ARHGDIA", "ARHGEF1", "ARHGEF2", "ARID1A", "ARIH1", "ARIH2", "ARL1", "ARL10", "ARL2", "ARL3", "ARL6IP1", "ARMT1", "ARPC1A", "ARPC2", "ARPC3", "ARPC4", "ARPC5", "ASAH1", "ASCC2", "ASCC3", "ASNA1", "ASNS", "ASPH", "ATAD1", "ATAD2", "ATAD3A", "ATAD3B", "ATE1", "ATG3", "ATG4B", "ATG7", "ATG9A", "ATIC", "ATL2", "ATP13A1", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6", "ATP6AP1", "ATP6AP2", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1D", "ATP6V1E1", "ATP6V1H", "ATP7B", "ATPIF1", "ATRIP", "ATXN2L", "AUP1", "AURKA", "AURKB", "B3GALT6", "B4GAT1", "BAG2", "BAG4", "BAG5", "BAG6", "BAIAP2", "BAK1", "BANF1", "BASP1", "BAZ1A", "BAZ1B", "BCAP31", "BCCIP", "BCL2L13", "BCLAF1", "BCS1L", "BICD2", "BIRC6", "BLMH", "BLVRA", "BMS1", "BNIP1", "BOD1", "BOLA2*", "BOP1", "BPHL", "BPNT1", "BRAP", "BRD2", "BRIX1", "BSG", "BTAF1", "BTF3", "BUB1B", "BUB3", "BUD23", "BUD31", "BYSL", "BZW1", "BZW2", "C1QBP", "C1orf35", "C2CD5", "CAB39", "CACUL1", "CACYBP", "CAD", "CALD1", "CALM3", "CALR", "CALU", "CAMK1", "CAMK2G", "CAND1", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPRIN1", "CAPZA1", "CAPZA2", "CAPZB", "CARM1", "CARS", "CARS2", "CASK", "CAST", "CBR1", "CBX1", "CBX3", "CBX5", "CBX8", "CCAR1", "CCAR2", "CCDC124", "CCDC22", "CCDC47", "CCDC6", "CCDC86", "CCNB1", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2AP", "CD2BP2", "CD320", "CD47", "CDC20", "CDC23", "CDC27", "CDC34", "CDC37", "CDC40", "CDC42", "CDC5L", "CDC7", "CDC73", "CDH2", "CDIPT", "CDK1", "CDK2", "CDK4", "CDK5", "CDK5RAP3", "CDK6", "CDKAL1", "CDKN2A", "CDS2", "CEBPZ", "CECR2", "CELF2", "CENPV", "CEP290", "CEP44", "CEP55", "CERS1", "CERS2", "CETN2", "CFAP20", "CFL1", "CFL2", "CHAC2", "CHAF1A", "CHAF1B", "CHAMP1", "CHCHD3", "CHD1", "CHD1L", "CHD4", "CHERP", "CHID1", "CHKA", "CHMP1A", "CHMP2A", "CHMP2B", "CHMP3", "CHMP4B", "CHMP5", "CHORDC1", "CHRAC1", "CHST14", "CHTF18", "CIAPIN1", "CIP2A", "CIRBP", "CISD1", "CISD2", "CKAP4", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLCC1", "CLCN3", "CLCN7", "CLGN", "CLIC1", "CLIC4", "CLINT1", "CLN5", "CLNS1A", "CLPB", "CLPP", "CLPX", "CLTA", "CLTC", "CLU", "CLUH", "CMAS", "CMPK1", "CMSS1", "CMTR1", "CNDP2", "CNN3", "CNNM3", "CNNM4", "CNOT1", "CNOT2", "CNOT9", "CNP", "COASY", "COIL", "COLEC12", "COLGALT1", "COMMD1", "COMT", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS2", "COPS4", "COPS5", "COPS6", "COQ8A", "COQ9", "CORO1B", "CORO1C", "CORO7", "COTL1", "COX18", "COX2", "COX4I1", "COX5A", "COX5B", "COX7A2", "CPD", "CPNE1", "CPNE3", "CPOX", "CPSF1", "CPSF2", "CPSF3", "CPSF6", "CPSF7", "CPT1A", "CPT2", "CPVL", "CRK", "CRKL", "CRNKL1", "CROT", "CRTAP", "CRYZL1", "CS", "CSDE1", "CSE1L", "CSK", "CSNK1A1", "CSNK2A2", "CSNK2B", "CSRP2", "CSTB", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTCF", "CTDSPL2", "CTNNA1", "CTNNAL1", "CTNNB1", "CTNND1", "CTPS1", "CTPS2", "CTR9", "CTSA", "CTSB", "CTSC", "CTTN", "CTTNBP2NL", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CUTA", "CWC15", "CWC27", "CWF19L1", "CXorf57", "CYB5B", "CYB5D2", "CYB5R1", "CYB5R3", "CYC1", "CYFIP1", "CYFIP2", "CYP20A1", "CYP51A1", "DAD1", "DAG1", "DAP3", "DARS", "DARS2", "DAXX", "DAZAP1", "DBN1", "DBNL", "DBT", "DCAF13", "DCAF7", "DCAKD", "DCD", "DCP1B", "DCPS", "DCTD", "DCTN1", "DCTN2", "DCTN3", "DCTN4", "DCTPP1", "DCUN1D1", "DCUN1D5", "DCXR", "DDAH2", "DDB1", "DDI2", "DDOST", "DDRGK1", "DDT", "DDX1", "DDX10", "DDX17", "DDX18", "DDX20", "DDX21", "DDX23", "DDX24", "DDX27", "DDX28", "DDX39A", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX50", "DDX51", "DDX52", "DDX54", "DDX55", "DDX56", "DDX6", "DEGS1", "DEK", "DENR", "DERL1", "DERL2", "DFFA", "DGKE", "DHCR24", "DHCR7", "DHFR", "DHPS", "DHRS1", "DHRS4", "DHRS7", "DHRS7B", "DHX15", "DHX16", "DHX29", "DHX30", "DHX36", "DHX37", "DHX38", "DHX40", "DHX57", "DHX8", "DHX9", "DIAPH1", "DIAPH2", "DIAPH3", "DIDO1", "DIMT1", "DIS3", "DKC1", "DLAT", "DLD", "DLG3", "DLGAP5", "DLST", "DNAAF5", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJC1", "DNAJC10", "DNAJC19", "DNAJC2", "DNAJC3", "DNAJC7", "DNAJC8", "DNAJC9", "DNM1L", "DNM2", "DNMT1", "DNPH1", "DNTTIP2", "DOCK7", "DOHH", "DOLPP1", "DPAGT1", "DPH2", "DPH5", "DPM1", "DPP3", "DPP9", "DPYSL2", "DPYSL5", "DRG1", "DRG2", "DSC3", "DSG2", "DSP", "DST", "DSTN", "DTYMK", "DUSP12", "DUSP3", "DUSP9", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNC1LI2", "DYNLL2", "EARS2", "EBNA1BP2", "ECD", "ECE1", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "EDC3", "EDF1", "EEF1A2", "EEF1B2", "EEF1D", "EEF1G", "EEF2", "EFCAB14", "EFL1", "EFTUD2", "EHD1", "EHD4", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B5", "EIF2D", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAC2", "ELAVL1", "ELMO2", "ELMOD2", "ELOB", "ELOC", "ELP1", "ELP2", "ELP3", "EMC1", "EMC2", "EMC4", "EMC7", "EMD", "EMG1", "EML4", "ENAH", "ENDOD1", "ENO1", "ENO2", "ENOPH1", "EPB41", "EPB41L2", "EPB41L3", "EPB41L5", "EPDR1", "EPHA7", "EPHX1", "EPHX2", "EPPK1", "EPRS", "EPS15L1", "ERAL1", "ERAP1", "ERC1", "ERCC2", "ERCC3", "ERCC6L", "ERGIC3", "ERH", "ERLIN1", "ERLIN2", "ERMP1", "ERO1A", "ERP29", "ERP44", "ESD", "ESF1", "ESPL1", "ESYT1", "ESYT2", "ETF1", "ETFA", "ETFB", "ETFDH", "ETNK1", "EWSR1", "EXO1", "EXOC2", "EXOC3", "EXOC5", "EXOC8", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC9", "EZR", "F11R", "FABP5", "FADS2", "FAF1", "FAF2", "FAHD1", "FAM208A", "FAM213A", "FAM3C", "FAM49B", "FAM50A", "FAM98A", "FAM98B", "FANCD2", "FANCI", "FAR1", "FARP1", "FARS2", "FARSA", "FARSB", "FASN", "FASTKD2", "FAU", "FBL", "FBXO21", "FBXO22", "FCGRT", "FDFT1", "FDPS", "FDXR", "FECH", "FEN1", "FERMT2", "FGFR1OP", "FH", "FHL1", "FHOD1", "FIP1L1", "FIS1", "FKBP10", "FKBP14", "FKBP1A", "FKBP2", "FKBP3", "FKBP4", "FKBP5", "FKBP7", "FKBP8", "FKBP9", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FMR1", "FN3KRP", "FNTA", "FNTB", "FOXRED1", "FSCN1", "FTL", "FTO", "FTSJ3", "FUBP1", "FUBP3", "FUCA1", "FUCA2", "FUNDC2", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GAK", "GAL", "GALK1", "GALNT1", "GALNT2", "GALNT4", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GATAD2B", "GBA", "GBE1", "GBF1", "GCAT", "GCC2", "GCDH", "GCLC", "GCN1", "GDI1", "GDI2", "GDPD1", "GEMIN4", "GEMIN5", "GET4", "GFM1", "GFPT1", "GGCT", "GGCX", "GGH", "GGPS1", "GHDC", "GIGYF2", "GLA", "GLB1", "GLDC", "GLG1", "GLMN", "GLO1", "GLOD4", "GLRX3", "GLS", "GLT8D1", "GLUD1", "GLYR1", "GM2A", "GMFB", "GMPPB", "GMPS", "GNA13", "GNAI2", "GNAI3", "GNG12", "GNL2", "GNL3", "GNL3L", "GNPAT", "GNPDA1", "GNS", "GOLGA2", "GOLGA3", "GOLGA5", "GOLGB1", "GOLPH3", "GOPC", "GOSR1", "GOT1", "GOT2", "GPAA1", "GPAM", "GPAT4", "GPATCH4", "GPATCH8", "GPD2", "GPHN", "GPI", "GPKOW", "GPR107", "GPR89B", "GPS1", "GPT2", "GRAMD1A", "GRB2", "GRHPR", "GRIPAP1", "GRPEL1", "GRSF1", "GRWD1", "GSPT1", "GSR", "GSS", "GSTK1", "GSTM3", "GSTO1", "GTF2B", "GTF2E1", "GTF2F1", "GTF2I", "GTPBP1", "GTPBP10", "GTPBP3", "GTPBP4", "GUF1", "GYG1", "GYS1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACD2", "HACD3", "HACL1", "HADH", "HADHA", "HADHB", "HAT1", "HAUS4", "HBS1L", "HCCS", "HCFC1", "HDAC1", "HDAC2", "HDGF", "HDGFL2", "HDHD2", "HDLBP", "HEATR1", "HEATR3", "HEATR6", "HEBP1", "HEBP2", "HECTD1", "HELLS", "HEXA", "HEXB", "HGS", "HIBADH", "HIBCH", "HIKESHI", "HINT2", "HINT3", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLTF", "HM13", "HMBS", "HMCES", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMGCL", "HMGCR", "HMGCS1", "HMGN2", "HMMR", "HMOX1", "HMOX2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPLL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HNRNPUL2", "HP1BP3", "HPRT1", "HPS6", "HS2ST1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSDL1", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA13", "HSPA14", "HSPA1B", "HSPA2", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPB1", "HSPBP1", "HSPD1", "HSPE1", "HSPH1", "HTATSF1", "HTRA2", "HUWE1", "HYOU1", "IARS", "IARS2", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDI1", "IFT27", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IK", "IKBKG", "ILF2", "ILF3", "ILK", "ILKAP", "ILVBL", "IMMT", "IMP3", "IMP4", "IMPA1", "IMPAD1", "IMPDH1", "IMPDH2", "INA", "INCENP", "INTS11", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IQGAP2", "IRGQ", "IRS4", "IST1", "ITCH", "ITGB1", "ITM2C", "ITPA", "IVD", "JUP", "KARS", "KAT7", "KCTD12", "KCTD5", "KDELC2", "KDELR1", "KDM1A", "KDM1B", "KDM2A", "KDM3B", "KDSR", "KHDRBS1", "KHSRP", "KIAA0368", "KIAA0391", "KIAA1147", "KIF11", "KIF14", "KIF15", "KIF18B", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF4A", "KIF5B", "KIFBP", "KIFC1", "KIN", "KLC1", "KLC2", "KMT2A", "KNTC1", "KPNA1", "KPNA2", "KPNA3", "KPNA6", "KPNB1", "KRI1", "KRR1", "KTN1", "L2HGDH", "LAMP1", "LAMP2", "LAMTOR1", "LANCL2", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LAS1L", "LASP1", "LBR", "LDAH", "LDHA", "LDHB", "LEMD2", "LEMD3", "LETM1", "LGALS3BP", "LGMN", "LIG1", "LIG3", "LIMA1", "LIPA", "LMAN2", "LMNB1", "LMNB2", "LNPEP", "LNPK", "LONP1", "LPCAT1", "LPCAT3", "LPGAT1", "LRBA", "LRP1", "LRPAP1", "LRPPRC", "LRRC40", "LRRC47", "LRRC59", "LRWD1", "LSM2", "LSM3", "LSM4", "LSM6", "LSM7", "LSS", "LTA4H", "LUC7L", "LUC7L2", "LYAR", "LYPLA1", "LZIC", "LZTFL1", "M6PR", "MACF1", "MAD2L1", "MAGT1", "MAIP1", "MAK16", "MAN1A1", "MAN2A1", "MAN2B1", "MANF", "MAP1B", "MAP1S", "MAP2K2", "MAP4", "MAPK1", "MAPK14", "MAPRE1", "MAPRE2", "MARC1", "MARCH5", "MARS", "MASTL", "MAT2A", "MAT2B", "MATR3", "MAU2", "MAVS", "MBD3", "MBOAT7", "MCAT", "MCCC1", "MCCC2", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCMBP", "MCTS1", "MCU", "MDC1", "MDH1", "MDH2", "MDN1", "ME1", "ME2", "MECP2", "MED21", "MED23", "MED24", "MED25", "MEPCE", "METAP2", "METTL13", "METTL14", "METTL3", "METTL7A", "METTL7B", "METTL9", "MFN1", "MFN2", "MFSD3", "MFSD5", "MGEA5", "MGME1", "MGST2", "MGST3", "MIA3", "MICU1", "MICU2", "MIF", "MINDY3", "MIPEP", "MKI67", "MKRN2", "MLEC", "MMAB", "MMS19", "MOGS", "MORF4L1", "MOV10", "MPC2", "MPG", "MPHOSPH10", "MPI", "MPP1", "MPRIP", "MPST", "MPV17", "MRC2", "MRE11", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL14", "MRPL15", "MRPL17", "MRPL19", "MRPL21", "MRPL22", "MRPL23", "MRPL24", "MRPL28", "MRPL3", "MRPL37", "MRPL39", "MRPL40", "MRPL44", "MRPL45", "MRPL46", "MRPL55", "MRPL58", "MRPL9", "MRPS11", "MRPS15", "MRPS16", "MRPS18A", "MRPS22", "MRPS23", "MRPS25", "MRPS27", "MRPS30", "MRPS31", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRPS9", "MRRF", "MRTO4", "MSH2", "MSH3", "MSH6", "MSI2", "MSMO1", "MSN", "MTA1", "MTA2", "MTAP", "MTCH1", "MTDH", "MTHFD1", "MTHFD1L", "MTHFD2", "MTMR14", "MTMR2", "MTOR", "MTPAP", "MTPN", "MTR", "MUT", "MVK", "MYBBP1A", "MYCBP", "MYEF2", "MYG1", "MYH10", "MYH9", "MYL6", "MYO1B", "MYO1C", "MYO1D", "MYO6", "NAA15", "NAA25", "NAA40", "NAA50", "NADK2", "NAE1", "NAF1", "NAGA", "NAGLU", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NAPG", "NARS", "NASP", "NAT10", "NAXE", "NCAPD2", "NCAPD3", "NCAPG", "NCAPG2", "NCAPH", "NCBP1", "NCBP3", "NCKAP1", "NCL", "NCLN", "NCSTN", "ND1", "NDC1", "NDUFA13", "NDUFA4", "NDUFA5", "NDUFA7", "NDUFA8", "NDUFA9", "NDUFAF2", "NDUFAF4", "NDUFAF7", "NDUFB1", "NDUFB10", "NDUFB3", "NDUFB4", "NDUFB5", "NDUFB6", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS6", "NDUFS7", "NDUFS8", "NDUFV1", "NDUFV2", "NEFL", "NEFM", "NEK9", "NELFCD", "NELFE", "NEMF", "NENF", "NES", "NFU1", "NGDN", "NHP2", "NIFK", "NIP7", "NIPSNAP1", "NKRF", "NKTR", "NLN", "NLRX1", "NME1", "NMT1", "NNT", "NOA1", "NOB1", "NOC2L", "NOC3L", "NOC4L", "NOL10", "NOL11", "NOL6", "NOL7", "NOL8", "NOL9", "NOLC1", "NOM1", "NONO", "NOP14", "NOP16", "NOP2", "NOP53", "NOP56", "NOP58", "NOP9", "NOSIP", "NPC1", "NPC2", "NPEPPS", "NPLOC4", "NPM1", "NRDC", "NSA2", "NSD2", "NSDHL", "NSF", "NSMCE2", "NSUN2", "NSUN5", "NT5C2", "NT5C3B", "NT5DC1", "NT5DC2", "NTHL1", "NTMT1", "NTPCR", "NUBP2", "NUBPL", "NUCB1", "NUCB2", "NUCKS1", "NUDC", "NUDCD2", "NUDT1", "NUDT16L1", "NUDT21", "NUDT5", "NUDT9", "NUF2", "NUFIP2", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP160", "NUP188", "NUP205", "NUP214", "NUP35", "NUP54", "NUP58", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NUTF2", "NVL", "NXF1", "NXN", "OAT", "OCLN", "OCRL", "OGDH", "OGT", "OLA1", "OPA1", "OSBP", "OSBPL3", "OSBPL6", "OSBPL8", "OSBPL9", "OSGEP", "OTUB1", "OTUD4", "OTUD7B", "OXA1L", "OXCT1", "OXSR1", "P3H1", "P3H4", "P4HA1", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PAF1", "PAFAH1B1", "PAFAH1B2", "PAFAH1B3", "PAICS", "PAIP1", "PAIP2", "PAK2", "PALLD", "PANK4", "PAPOLA", "PARG", "PARK7", "PARN", "PARP1", "PATL1", "PAWR", "PBK", "PBRM1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCID2", "PCK2", "PCLAF", "PCM1", "PCMT1", "PCNA", "PCYOX1", "PDAP1", "PDCD11", "PDCD5", "PDCD6", "PDCD6IP", "PDCL3", "PDE12", "PDE6D", "PDHA1", "PDHB", "PDIA3", "PDIA4", "PDIA5", "PDIA6", "PDK3", "PDLIM1", "PDLIM5", "PDLIM7", "PDPR", "PDXDC1", "PDXK", "PEBP1", "PECR", "PEF1", "PELO", "PELP1", "PEPD", "PES1", "PEX11A", "PEX14", "PEX16", "PEX19", "PEX5", "PFAS", "PFDN2", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGM3", "PGP", "PGRMC1", "PGRMC2", "PHAX", "PHB", "PHB2", "PHC2", "PHF5A", "PHF6", "PHGDH", "PHIP", "PHKA1", "PI4K2A", "PI4KB", "PIBF1", "PICALM", "PIGK", "PIGU", "PIK3R4", "PIN4", "PINX1", "PIP4K2C", "PIR", "PISD", "PITPNB", "PITRM1", "PKM", "PKMYT1", "PKN1", "PKN2", "PLA2G15", "PLAA", "PLBD2", "PLCG1", "PLD3", "PLD6", "PLEC", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLPBP", "PLS3", "PM20D2", "PMF1", "PMPCA", "PMPCB", "PMVK", "PNKP", "PNN", "PNO1", "PNP", "PNPLA6", "PNPT1", "POFUT1", "POLA1", "POLD1", "POLD3", "POLDIP2", "POLDIP3", "POLE", "POLE3", "POLE4", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2A", "POLR2B", "POLR2C", "POLR2D", "POLR2E", "POLR2F", "POLR2G", "POLR2L", "POLR3A", "POLR3C", "POLRMT", "PON2", "POP1", "POR", "PPA1", "PPA2", "PPAN", "PPAT", "PPIB", "PPIC", "PPID", "PPIF", "PPIH", "PPIL1", "PPIL3", "PPIL4", "PPM1G", "PPME1", "PPOX", "PPP1CA", "PPP1CB", "PPP1R10", "PPP1R12A", "PPP1R8", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP2R5E", "PPP3CA", "PPP4C", "PPP4R1", "PPP4R3A", "PPP5C", "PPP6C", "PPP6R3", "PPT1", "PPT2", "PPWD1", "PRC1", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PREP", "PREPL", "PRIM1", "PRIM2", "PRKAA2", "PRKACA", "PRKAG1", "PRKAR1A", "PRKAR2A", "PRKCB", "PRKCSH", "PRKDC", "PRKRA", "PRMT1", "PRMT3", "PRMT5", "PRMT9", "PRPF19", "PRPF31", "PRPF38B", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPSAP1", "PRPSAP2", "PRRC1", "PRRC2A", "PRRC2C", "PRTFDC1", "PSAP", "PSAT1", "PSIP1", "PSMA1", "PSMA3", "PSMA4", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD6", "PSMD7", "PSMD9", "PSME1", "PSME2", "PSME3", "PSME4", "PSMG1", "PSPC1", "PTBP1", "PTCD3", "PTDSS1", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK7", "PTPA", "PTPMT1", "PTPN1", "PTPN11", "PTPRF", "PTRH2", "PUDP", "PUF60", "PUM1", "PUM3", "PURA", "PUS7", "PWP1", "PWP2", "PXN", "PYCR1", "PYCR2", "PYCR3", "PYGB", "PYGL", "QARS", "QKI", "QRSL1", "QSOX2", "QTRT2", "RAB10", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB1B", "RAB21", "RAB24", "RAB31", "RAB39A", "RAB3GAP1", "RAB3GAP2", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RAB8A", "RAB9A", "RABAC1", "RABEP1", "RABGAP1", "RABL6", "RAC1", "RACGAP1", "RACK1", "RAD21", "RAD23A", "RAD23B", "RAD50", "RAE1", "RAI14", "RALA", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP6", "RANBP9", "RANGAP1", "RAP2B", "RAPGEF2", "RARS", "RARS2", "RAVER1", "RBBP5", "RBBP6", "RBBP7", "RBM10", "RBM12", "RBM14", "RBM17", "RBM19", "RBM22", "RBM25", "RBM26", "RBM27", "RBM28", "RBM34", "RBM39", "RBM4", "RBM5", "RBM6", "RBM8A", "RBMX", "RBP1", "RCC1", "RCC2", "RCL1", "RCN1", "RCN2", "RDH11", "RDH13", "RDH14", "RDX", "RECQL", "REEP4", "RER1", "RETSAT", "REXO4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RFT1", "RHBDD2", "RHEB", "RHOG", "RHOT1", "RHOT2", "RIDA", "RMDN1", "RMDN3", "RNASEH2A", "RNASET2", "RNF139", "RNF14", "RNF20", "RNF219", "RNF40", "RNH1", "RNPEP", "ROCK1", "RPA1", "RPA2", "RPAP1", "RPF1", "RPF2", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPN1", "RPN2", "RPP30", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS28", "RPS29", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RPTOR", "RPUSD3", "RRBP1", "RRM1", "RRM2", "RRP1", "RRP12", "RRP1B", "RRP36", "RRP8", "RRP9", "RRS1", "RSL1D1", "RSL24D1", "RSPRY1", "RTCB", "RTN4", "RTN4IP1", "RTRAF", "RUFY1", "RUVBL1", "RUVBL2", "S100A11", "S100A13", "SACM1L", "SAE1", "SAFB", "SAFB2", "SAMD4B", "SAMHD1", "SAP18", "SAR1A", "SARM1", "SARNP", "SARS", "SARS2", "SART1", "SART3", "SBDS", "SCAF1", "SCAF4", "SCAMP1", "SCAMP3", "SCARB1", "SCARB2", "SCCPDH", "SCD", "SCFD1", "SCML2", "SCO1", "SCO2", "SCP2", "SCPEP1", "SCRIB", "SCRN1", "SDCBP", "SDF4", "SDHA", "SDHB", "SDR39U1", "SEC11A", "SEC22B", "SEC23A", "SEC23B", "SEC23IP", "SEC24A", "SEC24B", "SEC24C", "SEC24D", "SEC31A", "SEC61A1", "SEC61B", "SEC61G", "SEC62", "SEC63", "SEH1L", "SENP3", "SEPHS1", "SEPT11", "SEPT2", "SEPT6", "SEPT7", "SEPT9", "SERBP1", "SERPINB6", "SERPINH1", "SET", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFXN1", "SFXN2", "SFXN4", "SGPL1", "SGTA", "SH3GL1", "SH3GLB1", "SH3GLB2", "SHMT1", "SHMT2", "SIGMAR1", "SIN3A", "SIRT1", "SKIV2L", "SKIV2L2", "SKP1", "SKP2", "SLC12A9", "SLC16A1", "SLC19A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A17", "SLC25A19", "SLC25A20", "SLC25A21", "SLC25A22", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A33", "SLC25A4", "SLC25A42", "SLC25A5", "SLC25A6", "SLC27A4", "SLC30A5", "SLC30A6", "SLC33A1", "SLC35A4", "SLC35B2", "SLC35F2", "SLC39A14", "SLC3A2", "SLC4A1AP", "SLC4A7", "SLC6A15", "SLC9A3R1", "SLFN11", "SLIRP", "SLIT2", "SLK", "SLTM", "SMAP1", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC6", "SMG5", "SMN1*", "SMNDC1", "SMPD4", "SMS", "SMYD3", "SNAP23", "SND1", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPC", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNW1", "SNX1", "SNX12", "SNX17", "SNX19", "SNX2", "SNX27", "SNX3", "SNX4", "SNX5", "SNX6", "SNX9", "SOAT1", "SOD2", "SON", "SORD", "SPAG9", "SPART", "SPATA5", "SPATA5L1", "SPC24", "SPCS2", "SPEN", "SPHK2", "SPNS1", "SPR", "SPTAN1", "SPTBN1", "SPTBN2", "SPTLC1", "SPTLC2", "SQLE", "SQSTM1", "SRCAP", "SREK1", "SRI", "SRM", "SRP14", "SRP54", "SRP68", "SRP72", "SRP9", "SRPK1", "SRPK2", "SRPRA", "SRPRB", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF3", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSNA1", "SSRP1", "STAG1", "STAG2", "STAM", "STAMBP", "STARD3", "STARD3NL", "STARD7", "STAT1", "STAT3", "STAU1", "STAU2", "STIM1", "STIP1", "STK26", "STK4", "STMN1", "STOM", "STOML2", "STRAP", "STRBP", "STRN", "STT3A", "STT3B", "STX10", "STX12", "STX18", "STX3", "STX4", "STX5", "STX7", "STX8", "STXBP3", "STXBP4", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGP2", "SUGT1", "SUN1", "SUN2", "SUPT16H", "SUPT5H", "SUPT6H", "SUPV3L1", "SURF4", "SURF6", "SUZ12", "SV2A", "SYNCRIP", "SYNE2", "TAB1", "TADA3", "TAF15", "TAF6L", "TAGLN2", "TALDO1", "TAOK1", "TAP1", "TARDBP", "TARS", "TARS2", "TBC1D13", "TBC1D15", "TBC1D2B", "TBC1D4", "TBC1D9B", "TBCA", "TBCD", "TBCE", "TBL2", "TBL3", "TBRG4", "TCAF1", "TCEA1", "TCERG1", "TCOF1", "TCP1", "TDRKH", "TECR", "TELO2", "TERF2IP", "TES", "TEX264", "TFAM", "TFB1M", "TFCP2", "TFG", "TFRC", "THOC1", "THOC2", "THOC3", "THOC5", "THOC6", "THOP1", "THRAP3", "THUMPD1", "THUMPD3", "TIA1", "TIAL1", "TIGAR", "TIMELESS", "TIMM10", "TIMM10B", "TIMM13", "TIMM17A", "TIMM17B", "TIMM23", "TIMM44", "TIMM50", "TIMM8B", "TIMM9", "TJP1", "TK1", "TKT", "TLN1", "TMCO1", "TMED10", "TMED9", "TMEM109", "TMEM165", "TMEM192", "TMEM201", "TMEM30A", "TMEM38B", "TMEM43", "TMEM59", "TMF1", "TMOD1", "TMOD3", "TMPO", "TMPO", "TMTC3", "TMX1", "TMX2", "TMX3", "TNKS1BP1", "TNPO1", "TNPO2", "TNPO3", "TOE1", "TOMM20", "TOMM22", "TOMM34", "TOMM40", "TOMM70", "TOP1", "TOP2A", "TOP2B", "TOR1AIP1", "TOR1B", "TOR3A", "TOX4", "TP53", "TPD52", "TPD52L2", "TPI1", "TPM1", "TPM3", "TPM4", "TPP1", "TPP2", "TPR", "TPT1", "TPX2", "TRA2A", "TRA2B", "TRAF2", "TRAM1", "TRAP1", "TRIM21", "TRIM25", "TRIM28", "TRIM33", "TRIP12", "TRIP13", "TRIR", "TRMT10C", "TRMT11", "TRMT1L", "TRMT2A", "TRMU", "TROVE2", "TRRAP", "TRUB1", "TSFM", "TSG101", "TSN", "TSNAX", "TSPO", "TSR1", "TST", "TTC1", "TTC26", "TTC4", "TTK", "TTLL12", "TTYH3", "TUBB", "TUBB2A", "TUBB2B", "TUBB3", "TUBB4B", "TUBB6", "TUBGCP2", "TUBGCP3", "TUBGCP4", "TUFM", "TWF1", "TWF2", "TWISTNB", "TWNK", "TXLNA", "TXLNG", "TXNDC12", "TXNDC17", "TXNDC5", "TXNDC9", "TXNL1", "TXNRD1", "TYMS", "U2AF1", "U2AF2", "U2SURP", "UAP1", "UBA1", "UBA2", "UBA3", "UBA6", "UBAP2L", "UBE2J1", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2O", "UBE2S", "UBE3A", "UBE4A", "UBE4B", "UBLCP1", "UBP1", "UBQLN2", "UBQLN4", "UBR4", "UBR5", "UBTF", "UBXN1", "UBXN7", "UCHL5", "UCK2", "UFC1", "UFD1", "UFL1", "UGCG", "UGGT1", "UGP2", "UGT8", "UHRF1", "ULK3", "UMPS", "UNC119", "UNC119B", "UNC45A", "UNG", "UPF1", "UQCR10", "UQCRC1", "UQCRC2", "URB1", "UROD", "USO1", "USP10", "USP11", "USP14", "USP28", "USP36", "USP39", "USP47", "USP48", "USP5", "USP7", "USP9X", "UTP11", "UTP14A", "UTP15", "UTP18", "UTP20", "UTP3", "UTP4", "UTP6", "UTRN", "UXT", "VAMP7", "VAPA", "VAPB", "VARS1", "VAT1", "VBP1", "VCL", "VCP", "VDAC1", "VDAC2", "VDAC3", "VIM", "VIRMA", "VKORC1L1", "VMP1", "VPS16", "VPS18", "VPS33B", "VPS35", "VPS37B", "VPS4A", "VPS4B", "VPS52", "VRK1", "VRK3", "WARS", "WBP11", "WBP2", "WDHD1", "WDR1", "WDR12", "WDR3", "WDR34", "WDR36", "WDR41", "WDR43", "WDR46", "WDR48", "WDR5", "WDR6", "WDR75", "WDR77", "WDR82", "WFS1", "WIPI2", "WIZ", "WLS", "XPNPEP1", "XPNPEP3", "XPO1", "XPO4", "XPO5", "XPO7", "XPOT", "XRCC1", "XRCC5", "XRCC6", "XRN2", "YARS", "YARS2", "YBX1", "YBX3", "YKT6", "YLPM1", "YME1L1", "YRDC", "YTHDC1", "YTHDC2", "YTHDF3", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2", "ZC3H11A", "ZC3H14", "ZC3H15", "ZC3H18", "ZC3HAV1", "ZC3HC1", "ZCCHC3", "ZCRB1", "ZDHHC13", "ZFR", "ZFYVE16", "ZMPSTE24", "ZMYM2", "ZNF207", "ZNF280C", "ZNF281", "ZNF318", "ZNF326", "ZNF512B", "ZNF622", "ZNF638", "ZPR1", "ZRANB2", "ZW10", "ZWINT", "ZYX"], "leading_proteins": ["ABCB1", "ABCB7", "ABCC1", "ABCD3", "ABHD10", "ABHD12", "ACAD9", "ACADVL", "ACAT2", "ACBD3", "ACBD5", "ACOX1", "ACOX3", "ACSF3", "ACSL1", "ACSL3", "AGK", "AGPAT5", "AGPS", "AIFM1", "ALDH3A2", "ALDH5A1", "ALDH6A1", "ALG1", "ALG11", "ALG12", "ANKLE2", "ANO10", "ANO6", "ANXA1", "ANXA11", "APLP2", "APOL2", "APP", "ARF4", "ASAH1", "ASNA1", "ATAD1", "ATP13A1", "ATP1A1", "ATP2A2", "ATP2B1", "ATP5B", "ATP5F1", "ATP5I", "ATP5L", "ATP6", "ATP6AP2", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1C1", "ATP6V1E1", "ATP7B", "B4GAT1", "BAG6", "BCL2L13", "BNIP1", "BSG", "C1QBP", "CALM3", "CALU", "CANX", "CCDC47", "CD320", "CD47", "CDC20", "CDIPT", "CDKAL1", "CERS1", "CERS2", "CHST14", "CIRBP", "CISD1", "CLCC1", "CLCN3", "CLCN7", "CLN5", "CLPP", "CLU", "CNNM3", "CNNM4", "CNOT1", "CNOT2", "COMT", "COPS4", "COPS5", "COPS6", "COQ9", "COX18", "COX2", "COX4I1", "COX5A", "COX7A2", "CPT2", "CPVL", "CRK", "CRTAP", "CRYZL1", "CTR9", "CTSA", "CTSB", "CUTA", "CYB5B", "CYB5D2", "CYB5R1", "CYC1", "CYP20A1", "CYP51A1", "DAG1", "DDX3X", "DEGS1", "DERL1", "DERL2", "DHCR24", "DHCR7", "DHFR", "DHRS1", "DHRS4", "DHRS7", "DHX36", "DLD", "DNAJC1", "DOHH", "DPAGT1", "DYNC1I2", "ECE1", "EFCAB14", "EIF3F", "EIF3H", "EIF4B", "EMC2", "EMC4", "EMC7", "EPDR1", "ERAP1", "ERLIN1", "ERO1A", "ESYT1", "FADS2", "FAM49B", "FASN", "FDFT1", "FECH", "FKBP10", "FKBP14", "FKBP1A", "FKBP7", "FKBP9", "FLOT1", "FMR1", "FNTA", "FOXRED1", "FUCA2", "FUNDC2", "FXR1", "GAA", "GAL", "GALNT1", "GALNT4", "GBA", "GGCX", "GLA", "GLB1", "GLUD1", "GM2A", "GNG12", "GNS", "GOLPH3", "GOSR1", "GPAA1", "GPHN", "GPR89B", "GTF2F1", "HACD3", "HADH", "HADHA", "HCCS", "HEXA", "HIKESHI", "HLA-A", "HLA-B", "HLA-C", "HMOX1", "HMOX2", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPDL", "HNRNPH1", "HS2ST1", "HSD17B11", "HSD17B12", "HSDL1", "HSPA9", "HTRA2", "ICMT", "ILVBL", "INA", "IPO9", "IRS4", "ITGB1", "ITM2C", "KDELR1", "KDM1B", "KDSR", "KHDRBS1", "KIF14", "KIF18B", "KMT2A", "KPNA2", "KPNA3", "L2HGDH", "LAMP1", "LBR", "LDAH", "LETM1", "LGALS3BP", "LGMN", "LNPEP", "LONP1", "LPCAT1", "LPGAT1", "MAGT1", "MAIP1", "MBOAT7", "MCL1", "METTL9", "MFSD3", "MGST2", "MGST3", "MICU2", "MIF", "MIPEP", "MMAB", "MPP1", "MSMO1", "MTAP", "MTCH1", "MTR", "NAGA", "NAGLU", "NAMPT", "NCLN", "NCSTN", "ND1", "NDC1", "NDUFA13", "NDUFA4", "NDUFA8", "NDUFB1", "NDUFB10", "NDUFB3", "NDUFB4", "NDUFB5", "NDUFB6", "NDUFB9", "NEFL", "NFU1", "NLN", "NNT", "NPC1", "NPEPPS", "NSMCE2", "NT5C3B", "NTMT1", "NUCB1", "NUCB2", "NUP107", "NUP155", "NUP205", "NUP35", "NUP54", "NUP62", "NUP85", "NUP88", "NUP93", "OLA1", "OPA1", "OXA1L", "P3H4", "P4HA1", "P4HB", "PARN", "PCYOX1", "PDCD5", "PDE12", "PDHB", "PEBP1", "PECR", "PEX14", "PEX19", "PGRMC1", "PGRMC2", "PHB", "PI4KB", "PIGK", "PIGU", "PITRM1", "PLA2G15", "PLBD2", "PLD3", "PLD6", "PLK1", "PMPCA", "PNPLA6", "POR", "PPP2R1B", "PPT1", "PPT2", "PRCP", "PREPL", "PRKAA2", "PRKAR1A", "PSAP", "PSMB2", "PSMB4", "PSMB6", "PSMD14", "PSMD7", "PSME3", "PTDSS1", "PTGES2", "PTPMT1", "PUM1", "RAB10", "RAB1A", "RAB1B", "RAB5B", "RACK1", "RBM10", "RCN2", "RDH13", "RDH14", "RETSAT", "RFT1", "RHBDD2", "RNF139", "RNF40", "RPL37", "RPN1", "RPS20", "RPS6KA3", "RPTOR", "RRM2", "RTN4IP1", "S100A13", "SCARB1", "SCARB2", "SCCPDH", "SCD", "SCFD1", "SCO1", "SCO2", "SCP2", "SCPEP1", "SDCBP", "SDF4", "SDHB", "SEC11A", "SEC61G", "SEC62", "SEC63", "SET", "SFXN1", "SFXN2", "SFXN4", 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20.83252427184466 0.7962580997895766 0.3538054675594747 3.0570578650205316 2.639985737842691 1.2479322885734705 0.312408674687376 0.0001827938571862 0.1594721229818057 0.0457762537637492 0.0014933754194455 0.0002236995277741 +Poor head control 17 72 2.815746079314669 0.0048664112316052 16.62864077669903 70.83495145631068 0.6551149189569596 0.4893764407721695 6.123760433086226 7.081833846449059 1.1601225008146194 0.3772060433763 1.116708344291483e-05 0.1553541085541318 0.1620510136895304 1.8485095573816343e-06 1.7163971434983485e-05 +Disproportionate short stature 10 24 2.811005238081368 0.0049386981876837 8.58252427184466 24.70145631067961 1.4449047806081987 0.2464238748623315 3.3320283680556178 3.793287097673045 1.0910515137563812 0.2952991105687103 0.0024690571952595 0.3498897642406863 0.2075521457010754 0.0602601519210857 0.0030990597522703 +Action tremor 20 55 2.802588912680235 0.0050694240707436 13.143203883495143 54.47572815533981 1.1235280535029035 0.3645421720231636 5.4627047451961745 5.814853194507433 1.1817578847970691 0.3688885139588422 0.0003254382029148 0.1306031110532128 0.0361024694746969 0.0011014507091605 0.00045073582254 +Progressive neurologic deterioration 8 18 2.7920028955948126 0.0052382887353874 6.75 20.466019417475728 0.5813429756502071 0.2930928839947513 2.6727908035631316 1.300228015706032 1.5791549964390388 0.3142214461904322 0.0001188800566425 0.0180235679120217 0.0628860756551618 0.0033331589242091 0.0001486944326884 +Myoclonic seizure 14 56 2.7847332161536937 0.0053571780385361 11.686893203883496 52.98543689320388 0.3944988422537482 0.4078474078990697 4.250245345088794 5.776566450302065 1.383306240067707 0.3629970156021384 0.0001357742188887 0.0053139908161637 0.0004883035754483 0.0001921569392551 0.0001958588770671 +Increased csf lactate 23 50 2.7810126225599623 0.0054189630126448 14.563106796116504 50.03398058252427 0.4527108683296134 0.4236743568986457 6.839235611227043 5.521257303659666 1.4241114192986506 0.3526497741057939 1.1528783413848017e-05 0.0680396063598938 0.0527430730742316 0.0002508021311022 1.6351107889003707e-05 +Central scotoma 5 10 2.7797929236963577 0.0054393571718891 3.657766990291262 9.152912621359222 1.2790732929494344 0.2261272578521709 2.0233738200365714 2.077016218281829 1.2675536526802949 0.279373459017325 0.0011888591401618 0.0073558029266518 0.0001142112625336 0.0003804824615668 0.0013842192735111 +Abnormality of head blood vessel 10 22 2.764080781011527 0.0057083405403812 7.512135922330097 24.881067961165048 0.5951213621611695 0.2501622891395578 2.541375726543966 2.628804376839775 1.8399520883426277 0.3043503409762604 7.684672383296738e-05 0.0335548880884004 0.0024974565689748 7.905769776099814e-05 0.0001000202970444 +Abnormal circulating cholesterol concentration 12 30 2.744408995811575 0.0060619959593464 9.691747572815531 31.70873786407767 0.976903841313624 0.2790879029908041 4.4525142732793395 3.04459115485426 1.5883623188049951 0.3063455707490317 3.2402428226197e-05 0.0055258914904556 0.0055866001960589 0.0003840000845849 4.399389009893932e-05 +Abnormality of femur morphology 28 60 2.7252539563764917 0.0064252045192727 17.20873786407767 66.68203883495146 0.8363246416857221 0.4265359075043799 5.791282481104246 7.777760660479065 1.2398669594969238 0.3848538433547022 0.0006436631874906 0.0668873192346767 0.0381560843457456 0.0178575058870057 0.0003634797128557 +Abnormality of pulmonary circulation 14 28 2.7219185491681945 0.0064904137240477 8.439320388349515 28.538834951456312 0.8940347945025898 0.342085103264471 3.349932259027002 4.295622811850572 1.233599840087162 0.3264185554851845 0.0036424246057341 0.4043878907472013 0.0817709134109805 0.0417924613880912 0.0046073357675181 +Mucosal telangiectasiae 6 10 2.718905134064355 0.0065498390248839 3.2354368932038833 9.689320388349516 0.8501086222195428 0.291727970426265 1.410916714116348 1.5996305775803197 1.2598794700933909 0.2907637890882055 0.0002123109398584 1.0 1.0 0.0004543195586384 0.0002545048715804 +Elevated pulmonary artery pressure 12 24 2.7182757767994623 0.0065623117067847 7.422330097087379 24.033980582524272 0.8771466934674594 0.3206437689207037 3.083196929894625 3.78086786662344 1.283632173810104 0.3146045769490745 0.0075447865129312 0.3498897642406863 0.0527430730742316 0.0602601519210857 0.0091923165902801 +Abnormal csf metabolite level 23 55 2.710046607010794 0.0067273754193588 15.62864077669903 56.38834951456311 0.3728365451013375 0.4594620050205593 7.183479908053284 5.909073177714687 1.318852118504194 0.3560984107552507 0.0001064390615983 0.0933835795341615 0.0817709134109805 0.0009781458417703 0.0001474663086914 +Hypopigmented skin patches 7 21 2.7020180978993644 0.0068920010855089 6.461165048543689 25.37135922330097 0.4666867513080546 0.4923758628930654 3.0339417473242687 3.9530564673509807 1.0171256647501936 0.3356931601315818 0.0672085257563972 0.3654998372428625 0.5945251193068862 0.0069141364236922 0.0768578600664919 +Generalized myoclonic seizure 11 41 2.6971223388696544 0.0069941569622336 9.177184466019416 40.04854368932039 0.4529392195590967 0.4207459458757411 3.6022058822892773 4.354728800706526 1.2466313924241157 0.3493918392140687 0.0012944661383134 0.0026483328470735 0.0001479893737495 0.000593819209885 0.0017086794106942 +Abnormality of alkaline phosphatase level 8 20 2.6904466393997257 0.0071356445642678 5.424757281553398 21.550970873786408 0.2837846270756372 0.4096308965627429 3.0903339262997473 2.8582743162812116 1.1598915940568888 0.2934678757183479 0.0021011786269148 0.2183067054048652 0.3865877370616545 0.1202502819228893 0.0025248287429058 +Subcutaneous nodule 8 18 2.674530215653676 0.0074834032328472 5.174757281553398 17.716019417475728 0.7715929851765809 0.3892857335439222 2.3624373807533945 1.5246949972287631 1.0645096840549642 0.3076166958299045 0.0113506300264735 1.0 0.4040169080940247 0.0388428633787512 0.0131933122365141 +Abnormal tissue metabolite concentration 8 14 2.6605371053391385 0.0078016130585665 5.895631067961165 14.650485436893204 0.4799987914691458 0.2340469593783387 2.3926019349714145 2.328417679576543 1.7567023743300048 0.2768423789344761 1.225433091978645e-05 0.1471951297158956 0.2709026461704186 0.0427102581002517 1.552122888068034e-05 +Respiratory distress 14 47 2.6598787674601163 0.0078168782309391 12.805825242718448 52.09466019417476 0.6386570898760532 0.4437575130669694 5.288397728288474 5.051988998968333 1.24726945526474 0.3693239953771813 0.0012386937379038 0.0038246242160168 0.0002782885377972 0.0003376828443168 0.0016577858338163 +Young adult onset 6 11 2.659831613971456 0.0078179726260791 3.936893203883495 11.097087378640778 0.9326277418903632 0.2839315553797075 1.7793033594374144 1.2484130750505644 1.1998221427979727 0.2831359733121 0.0005144971349197 0.1430638950507344 0.2638774705145789 0.0394981797992919 0.0006137659201312 +Scotoma 6 12 2.6587164659502105 0.0078438943708192 4.189320388349515 12.196601941747574 1.1271039056750725 0.2779036999445621 2.1128553643245884 2.0698220238662226 1.1901076059375446 0.2884356618441315 0.0093102627711643 0.0157111699130222 0.0005410615338916 0.002413529432882 0.0106779424109086 +Abnormality of the vasculature of the eye 18 65 2.653914222971218 0.0079564049480416 16.27912621359223 72.06553398058253 0.403343228775578 0.4479390001832676 5.629952078086087 5.671259209870798 1.3806507490937323 0.3789287537753926 0.0042088259106529 0.2998540533025085 0.1719583654290374 0.0081769764988723 0.0058130213776546 +Fluctuations in consciousness 4 7 2.626679428381578 0.0086222521111292 2.871359223300971 7.104368932038835 1.0899440920546752 0.2545542015295898 1.680977263462837 1.481694234866534 1.1451509420956862 0.2733842157028129 0.0013704364806795 0.0875404472016038 0.0137871179019738 0.0096601558647598 0.0015626966448138 +Increased serum lactate 49 102 2.621933252296922 0.0087432552912021 28.99514563106796 103.9126213592233 0.2156320103365802 0.4835633979758786 13.01418105275692 9.239117761559864 1.4606133548257267 0.3784654233889921 1.120455792705788e-09 0.0501087549876423 0.0244714513307757 3.372505765693903e-06 2.2103061891571912e-09 +Proximal tubulopathy 7 24 2.620200781357107 0.008787801060559 7.269417475728155 23.25 0.6812729764745832 0.3939568357360496 3.269858916003623 2.8782959157530654 1.2124757185225692 0.3205652179980567 0.0006601421792455 0.187449079081247 0.0628860756551618 0.0033331589242091 0.0008009677844218 +Progressive visual loss 6 22 2.6141588637051107 0.0089447435086784 5.325242718446602 22.429611650485437 0.7316954387450431 0.34231947196034 2.467466703195611 2.985791083259841 1.255625436621734 0.3056268024259221 0.0530973312771752 0.0490886173861251 0.0332955023502313 0.0987396264190218 0.0603451703095836 +Abnormal metabolic brain imaging by mrs 6 16 2.6079651873364837 0.0091082217017424 4.606796116504855 16.54854368932039 0.7235353195513555 0.4019359214719802 2.5477483733613684 2.1144608015049493 1.0143737900681629 0.2966800307492503 0.000759371118072 0.151306852499084 0.0412617301526311 0.0011455603346848 0.0009037066514027 +Abnormal csf protein level 5 11 2.6028492539180355 0.0092452594900815 4.434466019417476 12.20631067961165 1.1239853500963992 0.2260559983233297 2.11400242863219 2.084072511592451 1.241935948510828 0.248039542652958 0.0082248074208676 0.1715759324473242 0.0528695758908991 0.0132790770586149 0.0094438169248131 +Abnormal visual electrophysiology 16 47 2.5729935517488687 0.0100823086166077 11.310679611650484 49.08009708737864 0.5738496712827478 0.4298926605512212 5.601714588788375 4.822166856762376 1.2686017151039417 0.3684491475281102 0.002542321156755 0.0316897967394195 0.157470501429399 0.0213331031631142 0.0033597877926285 +Cns demyelination 5 12 2.572848900094761 0.010086523303487 4.330097087378641 13.868932038834952 0.932085489476866 0.3543850979390085 1.8689509518649636 1.4505793369743718 0.9962875819434424 0.3044831103069028 0.0025303492764951 0.1389130578490434 0.0348321279589049 0.0058861279901433 0.0029323640599066 +Hypocholesterolemia 6 8 2.5489544275066858 0.0108046418337313 3.2645631067961167 8.048543689320388 1.205673434171466 0.2055905154190861 1.747510449264718 1.0646904903887575 1.232151298114248 0.2464368010987078 5.620054649569796e-07 0.0017062060788896 0.0065261066260236 7.961542139625436e-06 6.862396837091624e-07 +Visual loss 15 44 2.542176022520332 0.0110164678122219 12.189320388349516 49.779126213592235 0.7709512625515322 0.4025114627500821 4.5744204921606055 5.175300864908489 1.242827263568942 0.3662286004483653 0.0126773395855222 0.0387857235824327 0.0613230666391858 0.0780431226308639 0.0160236102693128 +Ventricular hypertrophy 15 36 2.530939836957133 0.0113757358994461 10.04126213592233 36.45873786407767 1.1361758135608295 0.3518404639351837 4.440080726024568 4.153106961798495 1.0569836433105884 0.3376234863759063 0.0013194156014547 1.0 0.2285461090114013 0.0253147571163039 0.0016939651267837 +Abnormal social behavior 17 66 2.5278083611973066 0.0114776982718729 16.796116504854368 65.80339805825243 0.6678301735588785 0.4940185804874849 5.994105880514205 6.839540104535511 1.1033956384068455 0.3774724921329495 0.0005318169115232 0.0439310486951074 0.0709513936905264 0.0005262986824267 0.0007503944306292 +Morphological abnormality of the pyramidal tract 9 23 2.527341689446824 0.0114929625763622 5.978155339805825 21.21359223300971 0.941567362517309 0.4190895040605777 2.5839325217273803 2.130000617333851 0.9433759961177594 0.3444076850385922 0.0058901360116946 0.2516504230112798 0.1112999318055074 0.0537446424289807 0.0070021021764136 +Ascites 8 25 2.524979582057938 0.0115705011533886 6.538834951456311 25.800970873786408 0.2860997134153194 0.2561597752608451 2.6559964399945706 3.331112387328855 1.6846905274497244 0.2824645045304154 0.0050300651049544 0.290515894493261 0.1463784339168159 0.0264745204980689 0.0060795041439638 +Abnormal circulating albumin concentration 8 27 2.52107667386976 0.0116996355671683 7.694174757281553 30.737864077669904 0.0512821895236665 0.713635460899796 3.8191730219252498 2.7980963190446704 0.6378252165211873 0.2811475125216653 0.004573331063426 1.0 1.0 0.0844835592581437 0.0055341168642902 +Sensory neuropathy 11 32 2.5075391374854634 0.0121575117206722 9.17233009708738 33.75485436893204 0.684837850359792 0.4572087500958895 3.983815730493952 4.346698415431409 1.0448123352909229 0.3439679266340525 0.0001448702270821 0.3041527321586795 0.1596470307013262 0.102468551885206 0.0001907464755117 +Focal t2 hyperintense brainstem lesion 6 19 2.5068770936765983 0.0121803056491749 5.745145631067961 17.558252427184467 0.7787968952644161 0.3563659539921697 2.720936576360794 2.4403574571781053 1.1656572167307155 0.3009968442621839 0.0004182963988336 0.1389130578490434 0.0348321279589049 0.0007411998266354 0.000499607031549 +Postural tremor 6 17 2.498209826619967 0.0124822286548056 5.194174757281553 17.851941747572816 1.214872214945056 0.2487017685351703 2.341305968762478 2.2981463861426747 1.2391489410765593 0.2821199379659175 0.002073893767919 0.1755724648168266 0.0063919517402272 0.0003278350404254 0.0024504391694796 +Myoclonus 23 91 2.492465957069925 0.0126859490893191 19.92718446601942 92.40291262135922 0.7794869182612147 0.4142145469430702 6.660238401732631 11.33633180094438 1.369340457412049 0.3858779422292388 0.0007196302657863 0.0013362297014027 0.0029819108552072 0.0031524588325615 0.0010828277210432 +Dysesthesia 1 6 2.484388802932725 0.0129774031006164 1.3762135922330097 5.62621359223301 0.7008159231697947 0.4002775950461114 1.0271637039764925 1.2192199611233647 0.9765666303617 0.3018854922290938 0.0882392114562766 1.0 1.0 0.026793282710744 0.0928255051702242 +Increased cerebral lipofuscin 4 5 2.4841482645348663 0.0129861727192599 3.0970873786407767 5.118932038834951 1.0434065701738664 0.1270836154757583 1.1278862704044743 0.4599818751628888 1.7720117842909846 0.2267161680252343 4.192166113989691e-05 0.0009934566258862 0.0038356556834428 5.809602188645229e-05 4.83066106284651e-05 +Poor eye contact 10 39 2.471067533154112 0.0134710376557263 9.774271844660197 38.25970873786408 0.6634270903175611 0.4886810186458507 3.917228340019005 4.329065002822378 1.0573021214973186 0.3538640004920722 0.000524569374038 0.0490886173861251 0.0332955023502313 5.937182595886269e-05 0.0006708015430598 +Nephropathy 5 19 2.4684983852329654 0.0135681264235161 4.953883495145631 20.679611650485437 0.6460031144846833 0.4125859609731191 2.359716427347698 2.5216098734814283 1.0719980152629416 0.3150102108345451 0.0774996290220457 1.0 0.463832032870012 0.2001444771292485 0.0864752425233649 +Abnormal left ventricle morphology 13 26 2.468112289865403 0.0135827703762045 8.155339805825243 27.79368932038835 0.5948246759118737 0.4756129570470222 3.598158324912058 3.3281177777105677 1.054918773522773 0.3428402347836221 0.0127182784049838 1.0 0.544786927477571 0.3085032662868187 0.0151722507453241 +Incoordination 15 71 2.465102820967132 0.0136973938993383 15.859223300970871 69.11650485436893 0.6868183945924522 0.4621230815272417 5.5138472973140855 6.676725217396416 1.1752874861922693 0.3755559385684158 0.000297985940277 0.0088199695335766 0.0055675441345863 5.139806506656697e-05 0.0004301937975264 +Decreased activity of mitochondrial complex iv 2 16 2.4534361618573928 0.0141498652574072 3.878640776699029 15.9247572815534 0.8034271187166634 0.3445303465767608 2.844656052218728 1.5238137800378977 1.1422119451186783 0.2970372577525856 0.1359468257026162 0.0078974776787256 0.0288389511657702 0.027943905629812 0.1448535749943248 +Death in infancy 17 59 2.439647801244423 0.0147015873080791 13.932038834951456 59.75 0.0439382410072632 0.5469657686785577 6.0185992240596216 7.115764325899754 1.0162098878582335 0.3359539725870876 0.0003120036568093 0.1740449715143741 0.4420956530804403 0.1700094039277274 0.0004442503261214 +Reduced visual acuity 32 109 2.434477881867534 0.0149132912660683 25.553398058252423 114.88106796116504 0.4786956822479749 0.5063280215354549 8.433035081523723 11.838637206126975 1.2158495541746812 0.3830713742278179 4.590010535979331e-05 0.0057265435683818 0.0162855953542689 0.0005219242331505 8.15035057045244e-05 +Respiratory failure 19 63 2.427709345636902 0.0151945148623848 15.308252427184469 64.92233009708738 0.6334303745407566 0.5052857133990365 5.520010364276267 5.289556151454055 0.9962199001839442 0.3695677120431103 0.006104041353507 0.1757629685498992 0.0636605672499788 0.00438115490495 0.0079270137040918 +Hypertrophic cardiomyopathy 34 101 2.425502289283879 0.0152872193315576 26.796116504854368 107.3495145631068 0.4274787301303976 0.4988726739093555 10.944572821213892 9.196568310864103 1.312724112644841 0.3809066370755179 1.9669513131104725e-07 0.0971647579418701 0.1738229287918353 0.0011151747442132 3.7095401827027137e-07 +Abnormal vascular physiology 19 47 2.424382763825593 0.0153344335908309 12.74757281553398 50.021844660194176 0.816183607478715 0.4136638745601454 4.907827009322534 5.622165606934028 1.2216480011219424 0.371091913776798 0.005726149330818 0.5664012088569712 0.2247729980456782 0.052437625084942 0.0075287431073417 +Abnormal circulating citrulline concentration 3 5 2.413041790065674 0.0158200055741897 1.519417475728155 4.283980582524272 0.9322911204120568 0.2795135602214257 1.0297099461920487 1.0355035731992424 1.235992875942202 0.2843671782204088 0.0016284767730454 0.0561990347849709 0.0001725606130307 0.0024789777341693 0.0018160253024119 +Loss of speech 6 19 2.4096736131625325 0.0159667973129762 5.453883495145631 19.1626213592233 0.4726173662677797 0.3013153148889984 2.223071754411353 1.8941045281154043 1.521023928928509 0.3006842241053739 0.0027726610526052 0.0172375696548913 0.0603249601752956 0.0030026383245846 0.0032683125169143 +Abnormal circulating pyruvate family amino acid concentration 9 19 2.401114091946428 0.0163452393790501 6.320388349514563 20.366504854368937 0.081322462526961 0.4412434027627902 3.2290056548553094 3.0224314165009867 1.11319559933573 0.2886194174600295 7.3457844566887475e-06 0.1715759324473242 0.0528695758908991 0.0021528176338916 9.522552496337678e-06 +Arthritis 13 36 2.3969556452057077 0.0165319247753414 10.45631067961165 41.12864077669903 0.9299077951686036 0.3844403642845474 3.7326340917241647 4.351147052994631 1.200139433310656 0.3557501916131977 0.0004118850180853 0.4072806445693771 0.0835516544046861 0.0142757790525967 0.00055272694692 +Delusions 6 17 2.393721095720656 0.0166784258395464 5.912621359223301 18.439320388349515 1.0629964764413025 0.2985925736346436 2.390745896997379 2.2281751696560335 1.2165016471530676 0.297036724651636 0.0009122015439812 0.0121686135974036 0.004381787725469 0.0013109740347349 0.0010842824506653 +Abnormal conjunctiva morphology 9 25 2.392322372034812 0.016742129878732 6.997572815533981 26.58495145631068 0.5265054436970301 0.4429378103171669 2.669041123051977 2.4927208099742058 1.133049116684961 0.3300379664677785 0.0117576145278204 1.0 0.5984185130288913 0.0073174517980119 0.0142228592614621 +Abnormal brainstem mri signal intensity 7 22 2.3886736551194256 0.016909315005311 6.252427184466019 20.32281553398058 0.9466857218441096 0.334812084954676 2.9078682900486936 2.582646312540884 1.1241621585657078 0.2967087697298931 0.0002239678615548 0.1635258499471353 0.0480988323617951 0.0016937902873585 0.0002737502641485 +Infantile axial hypotonia 5 11 2.3854676105446937 0.0170574243465284 3.0970873786407767 9.91747572815534 0.2141703344813526 0.3664899290512883 1.6385203075306134 1.5973234399272347 1.21609252960959 0.2741067096589152 0.0021215648485544 0.134742527043449 0.2496255286594674 6.184484746355669e-05 0.0024615078608799 +Emg chronic denervation signs 6 13 2.378077384681119 0.0174031732305053 4.550970873786408 13.815533980582524 0.6176194543661773 0.3415909714455588 2.199917039284479 1.6085184210885628 1.2249413291120588 0.2985007469873863 7.283242839999046e-05 0.1093006244161378 0.0215793786244467 0.0022630844960047 8.773375017486012e-05 +Global brain atrophy 6 21 2.373033205835066 0.0176426777394476 4.944174757281553 20.466019417475728 0.5470181350831151 0.5081828354508747 2.583421763532785 2.0184370286085005 0.920761985531802 0.3339660659374047 0.0163024133917279 0.0196403757049561 0.0681167311872175 0.0040714376200731 0.0185916028453275 +Unexplained fevers 2 6 2.369473279834468 0.0178134421951436 1.5388349514563109 5.621359223300971 0.7467355824508212 0.3321409792965325 1.0149114466807625 0.7710351742240161 1.1275544850735062 0.2907731941603199 0.0155926449404773 0.0014481500629001 0.0055563644779973 0.0024789777341693 0.0168746974098865 +Stroke like episode 6 8 2.3598586197604847 0.0182819009726795 1.9320388349514563 5.347087378640777 0.7802983779647638 0.3377286829697849 1.3402806250303152 1.5433591727314462 1.1185957061594276 0.2970042406174105 0.0007871030357739 1.0 0.1500965904253892 0.0070197321203344 0.0008996004371504 +Fever 18 70 2.359470292126938 0.0183010461319372 15.842233009708735 82.04854368932038 0.3430938648437303 0.5687096412787555 5.789751815201478 7.962141782375792 0.9542673936922528 0.3482997682506425 0.0081317092550398 0.0942961333107097 0.0641383111217045 0.0430865246961953 0.0109276411697103 +Peripheral axonal neuropathy 16 56 2.3562027214131063 0.0184628388934258 13.890776699029129 56.6626213592233 0.647996206639266 0.5297865267121298 5.546380992609976 6.858150910061315 0.9851361073340408 0.3701043540632976 0.000133909896483 0.1354750356227081 0.1352243419874974 0.0403399114278366 0.0001905085993119 +Lower limb spasticity 19 76 2.351245002022674 0.018710709385884 17.24271844660194 80.34466019417475 0.5234592060757025 0.5553383930423336 6.384471482056576 8.884788223572686 0.9712236167697867 0.3629508150226985 0.0003022437937955 0.0582062335952951 0.0308349153392472 0.0001210426942219 0.0004418315212448 +Skin nodule 9 21 2.3360126452292307 0.0194905824972388 6.070388349514563 21.26456310679612 0.7442674094202993 0.3924071478475022 2.7239314899251803 2.029014432281319 1.0984628042075235 0.3129154853478004 0.0079112921611303 1.0 0.453417077782931 0.0622049447879163 0.0093715763041592 +Abnormality of retinal pigmentation 19 70 2.333378394415526 0.0196282942081227 17.82281553398058 72.90776699029126 0.3206615768516952 0.5948763422977358 6.463126466599106 8.392162193130181 0.987895502495544 0.3528647433942398 0.0101597252206223 0.6755398045514229 0.1775733386534337 0.0487069101580432 0.0067015174874558 +Severe short stature 10 22 2.328506720377588 0.0198852128151043 5.997572815533981 23.890776699029125 0.6572048998571618 0.4085599295800764 2.761119431778089 3.4934352273944844 1.0243280415736038 0.3082890569118746 0.0868506277644788 1.0 0.1867915963698719 0.0471384084482193 0.0977534096941649 +Segmental peripheral demyelination remyelination 2 5 2.3194746463814764 0.0203693142963263 1.6601941747572817 4.737864077669903 1.1231406516527276 0.2457358043386077 1.1021021225411718 1.375663406058269 1.1869683790120098 0.2709829643602553 0.0155926449404773 0.0561990347849709 0.0055563644779973 0.0024789777341693 0.0168746974098865 +Frequent falls 9 42 2.317828386450728 0.0204586497118455 8.643203883495145 38.75485436893204 0.6268988624161936 0.4831027569691007 4.0086529499315136 3.828305504664436 1.0909180744790496 0.3651237988976172 0.0005362942535109 0.0080720369936571 0.0090185147564143 3.4286382406703684e-05 0.0006963526490536 +Variable expressivity 21 78 2.3167243596330644 0.0205187517343115 16.655339805825243 76.72572815533981 0.9137081973948464 0.4866305980303022 6.903822328870412 7.203694993346709 1.0588933116250316 0.3878161256963057 0.0168088798329307 0.0796260892263804 0.0148872337954454 0.0014888737752957 0.0217198001082474 +Abnormal peripheral myelination 5 28 2.314878095388261 0.0206196044461335 7.635922330097087 32.13592233009709 0.6742900044491671 0.4743014543601314 3.568806451618386 4.873244854452022 0.9969709958674222 0.3457305187498817 0.0912128470555979 0.0614819278885333 0.0457599144631381 0.0491947466871055 0.1025545175555474 +Pathologic fracture 5 12 2.3137028994068585 0.0206840247493138 4.257281553398058 15.072815533980584 0.983166532607372 0.3143076297274698 2.133145812327421 2.2800397788540345 1.0713003315034937 0.2893419439464214 0.0082248074208676 0.1715759324473242 0.3116816529125438 0.0645860818166772 0.0094438169248131 +Leukodystrophy 14 54 2.3029166580125757 0.0212835327187288 14.718446601941748 56.94174757281554 0.1148532598751742 0.5363986626245857 6.478744148544089 5.4693767819453125 1.1351385962972955 0.354727749313835 1.17558539268227e-05 0.0832266786690803 0.0697861672765754 4.026784671831791e-06 1.695243623781953e-05 +Lacticaciduria 3 5 2.301440192933713 0.021366762259003 1.674757281553398 4.849514563106796 0.7129753583310345 0.3234768766519366 1.205184467740076 1.4436586333991552 1.2463576287305282 0.29112130721695 0.00402303968581 0.0697581245313758 0.0086772133501052 0.004864195908138 0.0044715029750658 +Central apnea 3 8 2.2977065698287773 0.021578495387279 2.6140776699029127 7.645631067961165 0.7865100475706397 0.3005269589284746 1.5309416715650457 0.8593604190958345 1.1613991531101726 0.2793709321885783 0.0225944645433979 0.1093006244161378 0.2052107238795277 0.0184993148019339 0.024870155511282 +Photophobia 13 36 2.296250005675321 0.0216615908433324 8.201456310679612 36.398058252427184 0.4678600054481162 0.5820727111270125 3.604298649244484 3.1999387306793547 0.8235485247156009 0.3378012969761652 0.0123467341566989 0.4544030019669794 0.1162445149363336 0.0769650581839678 0.015279019626754 +Abnormality of extrapyramidal motor function 26 76 2.290524117372627 0.0219909521476953 17.723300970873787 74.23058252427184 0.6611914449106878 0.5008095396366101 5.517064505158221 6.985611887807198 1.1554912414277594 0.3847143245763222 0.002847981881492 0.2586926984966432 0.0456665485201554 0.0243188669171802 0.0039300940709759 +Limb ataxia 7 25 2.289991453016852 0.0220218121164832 6.597087378640777 24.114077669902912 0.989869123864314 0.3154216467413447 2.5039369509835696 2.8496458430585005 1.1323309577692284 0.292147514752726 0.0053125653515578 0.2480154974279715 0.4319828126458854 0.0026455902306224 0.0063229831361219 +Generalized onset motor seizure 12 54 2.2824580327907604 0.022462312486706 11.152912621359222 52.41504854368932 0.3339582584761319 0.4862693619702651 4.390901477883725 5.9107493608976736 1.0930490316822232 0.3558024808092268 0.0035329337239245 0.0055731314175051 0.000529591303577 0.0028790470033439 0.0046397470814335 +Abnormal gallbladder morphology 11 30 2.2777218895169167 0.0227431527035786 7.478155339805825 31.075242718446603 0.4272058322069254 0.5481313499841369 3.2037612142007585 2.976716880674025 0.8468189606834012 0.3256570196959197 6.279985190656888e-05 0.0432831882721129 0.1398356665213448 0.0057860752251691 8.33223738562536e-05 +Paroxysmal involuntary eye movements 6 20 2.2759096576471483 0.0228514173466207 5.910194174757281 19.138349514563107 0.6558846901538902 0.3953776148518428 2.72692311425057 2.547182946947119 1.094018237549431 0.2977191822416544 0.0005144971349197 0.1430638950507344 0.0369282917904302 0.0008616614993304 0.0006137659201312 +Cognitive impairment 51 164 2.274246476697812 0.022951171261814 40.38834951456311 166.01456310679612 0.9678903819313606 0.4602309002251459 12.35477425089026 15.27402711863426 1.6121748345734526 0.4202585511538368 1.8366211006550286e-10 0.0636907608473699 0.0035473833802945 6.515974367982488e-05 5.429539077756703e-10 +Impaired vibration sensation in the lower limbs 4 16 2.273181212263931 0.023015261999991 3.5436893203883497 13.5752427184466 0.6952737045250533 0.4242336391370475 2.2993316843683766 2.2069327415111175 1.0005780794846004 0.3215228956981494 0.0319855186173056 0.1715759324473242 0.3116816529125438 0.0021528176338916 0.0356676925812392 +Undetectable electroretinogram 3 5 2.271009233012065 0.023146419021597 1.7427184466019416 4.415048543689321 1.0664751707047182 0.1916317897201908 0.9612998826677368 0.7632752290710167 1.383034454070232 0.2429274936147374 0.0022674499040627 0.0607401038440192 0.1169218221283287 0.0031665778749487 0.0025257820396667 +Abnormal renal tubule morphology 5 24 2.2701428518913325 0.0231989170649806 5.12378640776699 23.57281553398058 0.5344796879802587 0.5091115156098857 3.0444469953961124 3.073064760825049 0.9046179239778558 0.3270470399524735 0.1020984242959966 0.2870659866655126 0.14309893285135 0.0844835592581437 0.1133301273253246 +Capillary hemangioma 5 7 2.269611354299762 0.0232311741055306 2.533980582524272 7.133495145631068 1.1471796350867234 0.2683759543048971 1.4112277515033682 1.3471092449900268 0.9767941621718578 0.2786452679412407 0.016487126438091 0.1471951297158956 0.2709026461704186 0.5479465724917809 0.0185058115778357 +Anophthalmia 2 7 2.2693740786215373 0.0232455871365093 2.861650485436894 9.395631067961164 0.4842375076047043 0.4992513937830266 1.7811813452413223 2.297377217063272 0.8357915391858239 0.2927718406240587 0.4673539935292156 1.0 1.0 0.3766584026936453 0.4870031447296803 +Abnormal glycosylation 9 23 2.260762105039563 0.0237739923674837 6.043689320388349 21.259708737864077 0.4368319789530849 0.4886321385908432 2.9093144657736354 3.168109894482179 1.024724777664989 0.3264729071151926 2.3306068130951588e-05 0.1913705796369965 0.3439334989552355 0.0860045321118681 3.002075689864192e-05 +Emg neuropathic changes 9 23 2.24889081308508 0.0245194436423585 6.915048543689321 24.58252427184466 0.5887299592537784 0.4208819793990807 3.046574831105746 2.544837804909062 1.1306803597402475 0.3318248802653038 0.0001721327253482 0.1952735388158895 0.0681167311872175 0.0006301512333158 0.0002147665327233 +Abnormal muscle fiber morphology 27 69 2.243676866661932 0.0248531995813583 17.78640776699029 68.04126213592232 1.263675841483234 0.3649599499596623 6.500784844979595 6.6307423444197315 1.1691802531751734 0.3853191125649093 0.0029973230176994 0.0073073339713206 0.0185751728548963 0.0379650940986702 0.0039955604282077 +Abnormal protein glycosylation 8 19 2.2369204413670825 0.0252915402930697 4.992718446601942 17.04854368932039 0.4349711267577257 0.4629072595890348 2.62316887373748 2.93994465563356 1.0108477090998502 0.3020677841214376 2.6443864317915908e-05 0.1594721229818057 0.2915824887707032 0.0531009731762576 3.3367197281380665e-05 +Neuronal loss in central nervous system 6 11 2.227848434467152 0.0258906237736062 4.087378640776699 12.526699029126211 0.982175765643533 0.2959736314179056 1.731247914675439 1.993135251988059 1.1236470294677874 0.2967990988512021 0.0021215648485544 0.0090330503435184 0.032784445092202 0.0006337770004174 0.0024615078608799 +Areflexia 24 82 2.225598302253911 0.0260411000225966 20.16990291262136 86.04126213592232 0.3697353101404192 0.6748143831754785 7.040125425728686 10.82543509559568 0.6914116832707108 0.3259405906435058 0.0012826726166528 1.0 0.6254673162270674 0.0163107211557591 0.0018425630080954 +Dysmetria 25 52 2.224796634871708 0.026094893415576 14.618932038834952 55.148058252427184 0.6447099310037795 0.5301040823699991 5.464619727151339 6.3203263646610806 0.9326090127326924 0.3593910006397782 0.005203342954097 1.0 1.0 0.3505727031720007 0.0066239896089332 +Pedal edema 1 6 2.219048961646061 0.0264833937386002 2.092233009708738 7.211165048543689 0.6115824815809859 0.289867756561444 1.3297338459429695 1.219410808682535 1.3115580791228945 0.2762999280116011 0.3376138879681183 0.1178616319260966 0.2202973788945578 0.1258256892179061 0.3508562959456769 +Abnormal circulating non proteinogenic amino acid concentration 5 8 2.2173080243024628 0.0266020499318866 2.162621359223301 6.968446601941747 0.7521093084296674 0.2992197670299059 1.410866607722538 1.225329167014724 1.1887948503174883 0.2730524920497975 0.0004123278641389 0.0697581245313758 0.0003495610743441 0.004864195908138 0.0004723549730038 +Ankle clonus 4 12 2.2098085336739803 0.0271184532271091 3.575242718446602 13.298543689320388 0.6380030192173395 0.4332907678689981 2.0352878876827107 2.085711402355677 0.9658483329689804 0.311402478823635 0.0127215646374299 0.1389130578490434 0.2567853086841904 0.0007411998266354 0.0143108079403116 +Increased bone mineral density 8 24 2.207434854142428 0.027283693603358 6.242718446601942 24.75 1.1480702818250033 0.3148175930983396 2.4533156459354677 2.2345749579547443 1.0849696139569316 0.312718333498069 0.0078670198653715 0.3075216202298709 0.1629989722901094 0.009204426852113 0.009451753964434 +Rhizomelia 6 12 2.200877652238068 0.0277446863999968 4.276699029126213 11.868932038834952 1.3783619481702345 0.228956695884812 2.09278482575067 1.6655579622091714 0.936017394236602 0.2616202806826952 0.0046972970770791 1.0 0.356411341728891 0.0953125935026511 0.0055109462223793 +Progressive psychomotor deterioration 5 8 2.200715654906384 0.0277561598487325 3.349514563106796 8.320388349514563 0.5379615244672443 0.2176134167318772 1.5053866894387542 0.6226094824456632 1.5848775742530583 0.2457660654605461 6.691363253360277e-06 0.0561990347849709 0.1084298440104649 0.0024789777341693 7.93204060115495e-06 +Areflexia of lower limbs 11 24 2.1965830566327256 0.0280502373936966 6.601941747572815 21.186893203883496 0.8014885285213843 0.4297204254543569 3.042066893889402 3.372723692373783 0.977277602505203 0.3249512351298445 0.0046972970770791 1.0 0.356411341728891 0.0044813084875487 0.0055109462223793 +Abnormal retinal vascular morphology 14 45 2.188546574758867 0.0286298125500139 11.550970873786408 50.40291262135922 0.374132464893944 0.4137648703700375 4.646725961814426 4.349733979382428 1.4638612584769457 0.3720428539009304 0.0120270672455886 0.1706177828799348 0.0601718520481821 0.0115388434130444 0.0152201774374484 +Cherry red spot of the macula 6 9 2.183479670074268 0.0290005045014356 4.87621359223301 9.031553398058252 0.4125318500531191 0.1346012745180574 1.6566187440434876 0.4477283705000042 2.101542046986786 0.2228325403979826 2.700712343164126e-07 0.0561990347849709 0.0055563644779973 4.995899372658519e-06 3.301825045887433e-07 +Progressive spastic quadriplegia 3 8 2.180422467221749 0.0292261602395962 2.6407766990291264 8.094660194174757 0.8041722661618813 0.2980182786117089 1.3079619433616207 1.0302561803519357 1.23715789109981 0.2930725496255146 0.0007436411136795 0.0470522829573702 0.0912026913027489 0.0014005858473499 0.0008311382626552 +Impaired social interactions 11 48 2.174889985028684 0.0296383615937583 12.00242718446602 47.49029126213592 0.5604537103987376 0.5219910099489533 4.425488172516818 5.269200019661922 1.0091183008466462 0.3500212759055819 0.0008484382794588 0.0875356389619515 0.0748180082788048 0.0001606110277896 0.0011115031533168 +Cardiac conduction abnormality 8 31 2.1709999208392743 0.0299311783615043 7.54126213592233 30.07766990291262 0.9307918135366152 0.3911403090848463 3.486554807604548 3.5456504747498965 0.9289536354013204 0.3216072900435658 0.0158467947183591 0.3371313972628795 0.1936799284616789 0.0154579474619112 0.0188380479818626 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11.12378640776699 1.060494846441687 0.2663322982599159 1.9809215871966128 1.7630834730718608 1.1982900451883365 0.2840581402107739 0.0025303492764951 0.1389130578490434 0.0030930435255612 0.0364143419045942 0.0029323640599066 +Ventricular preexcitation 4 7 2.1649028029241384 0.0303951295225499 2.5145631067961167 6.497572815533981 0.9841118497305948 0.2225227126053997 1.468861772329754 1.5757549992030588 1.3097679632537274 0.2453287763295943 0.0098743721755282 0.0875404472016038 0.0137871179019738 0.0736296228832766 0.0109272978194228 +Abnormal larynx morphology 5 24 2.159599644893471 0.0308036759467702 6.839805825242719 27.718446601941743 0.5738284857128313 0.4761706892213789 2.8749956456134265 3.1319446353032743 0.987106786856402 0.3377886307734372 0.2085336767871006 0.0904452781629929 0.078260139280739 0.0386710340877583 0.229510196441206 +Macular degeneration 4 14 2.149820233894855 0.0315694370442287 3.5072815533980584 13.201456310679612 0.7081764422831481 0.3007939344006393 1.5711122114355351 1.3240485924903622 1.388921785741595 0.3097317018961461 0.089572178702168 0.0257535715284909 0.0014691652083679 0.0075761723461217 0.0985278262196681 +Shoulder girdle muscle weakness 3 11 2.1473943110677545 0.031761903177411 4.004854368932039 12.42233009708738 0.8387402263996985 0.3756529644451753 2.0785487207705367 2.2836026739757753 0.9187113892871612 0.2934865228782298 0.0631133577932044 0.1471951297158956 0.2709026461704186 0.0427102581002517 0.0688237498174009 +Abnormal circulating proteinogenic amino acid derivative concentration 9 20 2.146442321038728 0.0318377059005083 6.466019417475728 22.41990291262136 -0.1043960799147475 0.4436663838419124 3.4859371683050364 3.6090355851185105 1.119086827739467 0.288849387543065 4.296036063565212e-05 0.2030241760545403 0.0734859631006396 0.0049197328266328 5.512763040206096e-05 +Abnormality of temperature regulation 23 89 2.1442448030904595 0.0320132769268768 19.25485436893204 102.82038834951456 0.3970293406250321 0.5993116835261848 7.1176384711487035 9.956544993053525 0.8850362554833304 0.3476784016267602 0.0036848080239635 0.1612976563336116 0.0571880138782937 0.0427888890929403 0.0053113760119016 +Abnormal pericardium morphology 5 8 2.1363335858315886 0.0326522331892225 3.487864077669903 10.762135922330096 1.0304485268572945 0.2849705132346721 1.7172308655515107 1.695717994097398 1.0794817436655069 0.2735310781030822 0.0186204726532014 0.151306852499084 0.277861461810767 0.0460491564663638 0.0208773841861115 +Exercise intolerance 12 33 2.1315213906181745 0.033046212129981 7.589805825242719 32.94660194174757 0.6935647402019111 0.4794430320014746 3.6422804337959303 3.649320073231373 0.9787082553108852 0.3464451860868903 0.0066147237261145 0.0490886173861251 0.0332955023502313 0.0081096487576019 0.0079661437310143 +Abnormal epiphyseal ossification 10 16 2.1233471549478486 0.0337247719678783 6.451456310679611 16.274271844660195 1.1227269321938518 0.3276999393402902 3.140724178369711 2.4155680760400804 1.043634905787503 0.3148370578580727 0.0007749612801669 1.0 1.0 0.6532622229061094 0.0009391360652329 +Limb girdle muscle weakness 6 23 2.121220070649889 0.0339032870137225 6.385922330097087 25.211165048543688 0.7046294396116228 0.4863231890570912 2.9011373520939956 3.1532956410624498 0.797735822235521 0.3186211542147555 0.0312822361902386 0.2731012734555347 0.4689656122513949 0.0199702538754952 0.0358682060448421 +Underdeveloped supraorbital ridges 5 11 2.1200137004550927 0.0340048899223348 4.665048543689321 12.08980582524272 0.8524762858030893 0.4193185978455835 2.3718498265247017 1.7978393075824093 0.8920190977636392 0.3291411492922084 0.0180431808390396 1.0 1.0 1.0 0.0205537013389431 +Schizophrenia 7 17 2.1199082271735725 0.0340137854538173 5.444174757281553 19.50242718446602 0.9817145874838714 0.3473822480141803 2.400301366302062 2.641618717487706 1.084663392230114 0.3211478296747099 0.0004715345594425 0.0164667175849867 0.0068495888428019 0.0003765067193335 0.0005735240796309 +Demyelinating peripheral neuropathy 3 16 2.1103673642200627 0.0348267252798897 3.6189320388349513 16.41990291262136 0.8004175255851168 0.4261699448763591 1.908827430762096 2.446692237122478 0.9042326115295364 0.3171508979101954 0.1027420696545694 0.1715759324473242 0.0528695758908991 0.0132790770586149 0.1113673324487233 +Spastic paraparesis 5 21 2.102457358770162 0.0355132311932442 5.478155339805825 20.550970873786408 0.6522343609765672 0.5124278683317688 2.4725696108954978 1.913118744158018 0.8986801667257259 0.3474119612866397 0.0146811150751496 0.1913705796369965 0.0083373177591013 0.0036890724660894 0.016761518835176 +Dyschromatopsia 2 6 2.0956886839213835 0.0361098163445943 1.9563106796116505 6.881067961165049 0.8116181676256156 0.3616454151850379 1.3027357251175682 1.008666728011197 0.9552278076961072 0.2951208666933738 0.0121016028986827 0.0516364610584135 0.0046590638338273 0.026793282710744 0.0131100293828519 +Gait ataxia 16 69 2.0938506945623128 0.0362732826052607 14.351941747572816 68.35194174757281 0.6787136514518399 0.4783255809544575 5.256980668043156 6.678826209042067 1.046898326537344 0.3693668840587258 0.0015257503125317 0.1878650647832112 0.2073860136465309 0.005930272892448 0.0020855881979959 +Abnormal pupillary function 2 5 2.0924665498540387 0.0363968010008515 1.7985436893203883 6.25 0.9459174425459445 0.2892194993230557 1.1928988171245156 1.7202745886032773 1.109204161812943 0.2732247962160634 0.1691745416852986 0.1389130578490434 0.2567853086841904 0.0364143419045942 0.1797662267162446 +Chronic fatigue 2 7 2.0819011061348323 0.0373515037364451 2.0800970873786406 7.354368932038835 0.6505903571445167 0.3551914870642563 1.248646642239502 1.3902068505046723 1.081635717396615 0.2816956203568134 0.0541824319759991 0.0875404472016038 0.1662183776826317 0.0096601558647598 0.0582282885441972 +Splenomegaly 26 78 2.0801666943341224 0.0375102459571285 20.660194174757283 86.74029126213593 0.5649049994066069 0.3835571498509289 6.419862077062851 7.868335701486235 1.546158503499524 0.3590721878602594 2.1377480600399666e-05 0.3052095683601886 0.1775733386534337 0.0034366482602024 1.263040695637759e-05 +Ectopic calcification 14 52 2.079527311376873 0.0375689102068943 13.553398058252426 56.53155339805825 0.5275931647443897 0.4410566614950294 4.995100814049753 5.994858194438004 1.2985638579898735 0.3743313818119885 0.0033129256534853 0.5123592328378659 0.1666719780928332 0.2751211971199749 0.0043562618914192 +Posterior embryotoxon 6 15 2.07712165049941 0.0377903328000104 5.400485436893204 18.211165048543688 0.5603270949007155 0.5260153972846668 2.4736082204804974 3.2255911781388433 0.9025074564453092 0.3301763927361542 0.0092734634325317 1.0 1.0 0.3508979217247462 0.0108038870628888 +Toe walking 9 20 2.070104400589276 0.0384425688899563 6.740291262135922 22.805825242718445 1.1386089770349623 0.3130572717722256 3.272869930973316 2.572476621751866 1.068544148592376 0.2998505070337083 0.0083462479583922 0.2183067054048652 0.3865877370616545 0.3422288333052919 0.0097349382788801 +Abnormality of glycolipid metabolism 5 7 2.0696555400761474 0.0384846130000473 3.83495145631068 7.228155339805825 0.3163887308740252 0.1681411938672545 1.311614193945771 0.5964160722258837 1.870431483654663 0.2292796295173983 1.6460538034731088e-06 0.0470522829573702 0.0912026913027489 0.0014005858473499 1.95600972362446e-06 +Abnormality of the gallbladder 13 36 2.0652232115087905 0.0389018852566149 9.223300970873789 38.0752427184466 0.5027702533780772 0.5379447420549962 3.587145439560844 3.3423828325522775 0.8984096284409542 0.3445277538035425 1.9350829454655408e-05 0.0589240460435226 0.183361016235644 0.0032604712946773 2.6852320995274902e-05 +Headache 12 60 2.058089045958542 0.0395815863380002 14.46359223300971 67.2621359223301 0.3081011079805987 0.6628919880538205 5.675371311469098 6.55256736914289 0.7433463084148959 0.331664631896279 0.1504226003266084 0.2586926984966432 0.3096269152871024 0.1150194821105734 0.1747601059732612 +Abnormality of epiphysis morphology 18 53 2.058052147443327 0.0395851278461563 14.885922330097088 57.24757281553398 0.6699051414631522 0.4959188251133739 5.664066249559964 8.729587504130462 1.029966158611096 0.3689041276003297 0.006933277136419 0.6049821640239788 0.545647232006766 0.4763455121370267 0.0041426631737335 +Peripheral axonal degeneration 26 69 2.0570073864189373 0.0396855153641704 16.691747572815533 71.19902912621359 0.6211832637355972 0.5650732986012978 6.425044282599762 8.4263916789636 0.8780908495791551 0.3675751486040735 0.0005318169115232 0.1861284851480595 0.2049282090120324 0.0416085684755994 0.0007503944306292 +Juvenile onset 14 41 2.0568046464813428 0.0397050209628235 10.220873786407768 41.28155339805825 0.3416766536043948 0.3540580800469471 3.658644665705508 2.990007551791468 1.4952530140825149 0.3282418399186692 0.000182240975592 1.0 0.6173373514131971 0.2134959758362166 0.000247074458599 +Temperature instability 4 8 2.0511120682191124 0.0402560343321805 2.563106796116505 8.077669902912621 0.5786926336202384 0.3539234625201496 1.6976277160735205 1.200237196527885 1.1389671471549596 0.2898062051573807 0.0013704364806795 0.0875404472016038 0.0137871179019738 0.0096601558647598 0.0015626966448138 +Progressive sensorineural hearing impairment 3 9 2.047993011748108 0.0405606841441859 3.1092233009708736 10.177184466019416 0.6816533912969537 0.4125027093829873 1.9409267075593708 1.400472817159746 0.9707665840558262 0.3067183945172701 0.0295853602598455 1.0 0.2202973788945578 0.1258256892179061 0.0324964959636656 +Increased serum pyruvate 10 33 2.047716855945964 0.0405877512436771 9.303398058252426 32.64563106796116 0.7845790996019184 0.387018609503293 3.945341127018032 3.24570744750092 1.0586848930233297 0.3138975633269482 9.358522379611776e-07 0.0213158974187442 0.0100008174701386 1.2674340008542711e-05 1.277430017883112e-06 +Avascular necrosis 7 19 2.046205667700648 0.0407361399589161 5.070388349514563 21.203883495145632 0.6420454351604097 0.3947374085674277 2.2614105153836106 2.2592172512550373 1.1319127818663337 0.3183649666305153 0.0150694369255238 0.2406936845278361 0.0168596271371444 0.0110971224242302 0.0174555494840385 +Abnormality of the alveolar ridges 2 6 2.0451301154646138 0.0408420319641413 2.1092233009708736 6.368932038834951 1.3424122348723253 0.2105791674194365 1.182482323454481 1.3741037061958896 0.9200079991465796 0.2386077675723682 0.1467611737455875 1.0 0.2423974925429197 0.1502583189770621 0.1562329747417322 +Progressive spasticity 6 15 2.044484359770661 0.0409057209494567 4.310679611650485 15.677184466019416 0.3665295652655519 0.4383580490709103 2.2099911092980777 1.5344471301085942 1.08331515350054 0.3117516214812866 0.0004740873189065 0.1049896535105009 0.1975594178204269 0.0019212884759336 6.476548304443044e-05 +Abnormal light and dark adapted electroretinogram 2 8 2.0391167222287483 0.0414383796494659 1.7985436893203883 7.135922330097087 0.8897551200199579 0.2742817695009352 1.2050451450005106 0.7670210145007976 1.1859557261264115 0.267107203595487 0.0616434698760561 0.0040679264544396 0.015225007352257 0.0111687214620054 0.0661818234522848 +Abnormal full field electroretinogram 2 8 2.0391167222287483 0.0414383796494659 1.7985436893203883 7.135922330097087 0.8897551200199579 0.2742817695009352 1.2050451450005106 0.7670210145007976 1.1859557261264115 0.267107203595487 0.0958043754265018 0.0058373227860703 0.0215793786244467 0.0184993148019339 0.1024634056988124 +Mania 6 12 2.0388258218419497 0.0414674142322573 4.29126213592233 13.815533980582524 0.5633198814967983 0.4160552944360035 2.179476502394243 2.2801276272213657 1.0919629859527038 0.3085705503430486 0.0025303492764951 1.0 0.2567853086841904 0.0364143419045942 0.000499607031549 +Dermal atrophy 4 26 2.0371797148200583 0.0416320358739352 5.320388349514563 26.895631067961165 0.7910895542770026 0.4477466139002859 2.6272049167180267 2.645986214694848 0.8422228280317593 0.3177571120785681 0.2446979698444775 1.0 0.1529837701743424 0.0294136582376105 0.2637270744630375 +Lipoma 2 6 2.033931084833148 0.041958544308196 1.8349514563106797 5.902912621359223 0.4037279439939651 0.5250573643743743 1.2115711325770333 1.0590760133596224 0.8450326002912417 0.3030833486104404 0.0406693637652179 1.0 1.0 0.0070197321203344 0.0437923930222569 +Decreased circulating level of specific antibody 2 5 2.0278719925722686 0.0425733142828643 2.121359223300971 6.533980582524272 0.4932007596736456 0.4788575500117063 1.7193445627120678 1.458590448587382 0.9533329302475996 0.3207672834212082 0.0616434698760561 1.0 1.0 0.3817570354203927 0.0661818234522848 +Abnormal large intestine physiology 7 19 2.0246139369852703 0.0429070220280469 5.104368932038835 20.50242718446602 0.3008286810865617 0.501154789704215 2.3382177969194613 2.943232146467361 0.9913296101531662 0.3267316971730095 0.001218538917013 0.2030241760545403 0.36256189343107 0.0049197328266328 0.0014713154324456 +Abnormality of skull ossification 7 12 2.022504811042918 0.0431242270797764 4.366504854368932 12.970873786407768 1.1881205011944458 0.2637442069575459 1.99249670608582 1.4511884027191762 0.8848235988748787 0.2626440236811827 0.0041137183930413 1.0 0.277861461810767 0.1927267877862009 0.0047506904504764 +Periventricular white matter hyperintensities 4 8 2.018368436918903 0.0435529040432893 2.978155339805826 8.604368932038835 0.7206271937008832 0.2495118997135797 1.313488091366194 1.3113693798075805 1.4898193087366574 0.2872267653893681 0.0004123278641389 0.0697581245313758 0.1336663515258769 0.004864195908138 0.0004723549730038 +Chorea 17 79 2.011884022795176 0.0442321639941252 15.728155339805824 83.02669902912622 0.3692790133375349 0.6638686972138231 5.807919224941267 8.199974294104807 0.7006105038887043 0.3242322398871146 0.0145357387607811 0.0914639750891306 0.019443857154527 0.0025353279419277 0.0190353289758384 +Retinal detachment 5 15 2.009364244642361 0.044498519229928 3.941747572815534 14.580097087378642 0.5369031517500233 0.5057677956850462 2.153458463438811 2.8955761353524423 0.8356573249695263 0.3047965741525345 0.2024558477419006 1.0 1.0 0.2186719915745684 0.2192178348635005 +Abnormality of the gastric mucosa 5 14 2.0085949211105603 0.0445801103830609 4.055825242718447 14.78883495145631 0.5194091581879025 0.5370124786963326 2.5206506419534382 1.2815235175981112 0.7811861742401941 0.3195792656212642 0.0055136683337418 0.1594721229818057 0.2915824887707032 0.0531009731762576 0.0063527072748022 +Primary adrenal insufficiency 4 12 2.006909456836006 0.0447593047236776 4.735436893203883 14.053398058252426 0.4481201134263297 0.4664055341667871 2.4306710395132063 2.5622470240832387 1.0298993153674545 0.3194227062256599 0.0386596480417249 1.0 1.0 0.6272404678588621 0.043017591530718 +Paraparesis 6 27 2.0059822647623107 0.0448581402385985 6.871359223300971 28.233009708737864 0.6400248426097842 0.4864726145707422 2.711080302193058 2.7797949337481977 0.9964067729408944 0.345088346487725 0.0195828489175404 0.2516504230112798 0.0024974565689748 0.0028823819769621 0.0226061192548448 +Punctate cataract 3 5 2.003884826920541 0.0450823992630013 1.1577669902912622 3.383495145631068 0.983483166388957 0.3140574400506079 0.8106469094037756 0.8665966337948645 1.0905098573512635 0.2894658565748023 0.0279981678659184 1.0 0.0557540441617295 0.0079014074338353 0.001897897013483 +3 methylglutaconic aciduria 6 11 2.003064903063061 0.0451703225278457 4.072815533980583 10.594660194174756 0.3579974396117663 0.4371570089867337 2.2174372584356252 1.5620718849823747 1.1566220028171512 0.333066618505644 0.0471864225344609 1.0 0.1581956798045988 0.0668959947775429 0.0507597110616669 +Epiphyseal stippling 6 11 2.0023940230303863 0.0452423708031639 4.638349514563107 12.094660194174756 1.0555865796987824 0.32401635996293 2.3050778042540805 1.737163917644219 0.9677864882437331 0.2966156619887163 0.0002689054738225 1.0 1.0 0.5022110525395543 0.0003219556331171 +Progressive gait ataxia 5 12 2.000956009638993 0.045397130770947 3.3810679611650487 11.0873786407767 0.9190295749650902 0.2658532875386696 1.7592835107251577 1.880439920211323 1.2434873962438642 0.2734996669217905 0.0004740873189065 0.0053672672920639 0.0199028792923938 0.000171368540682 0.0005546107272876 +Focal segmental glomerulosclerosis 3 19 1.994398527583486 0.046108519308071 5.546116504854369 21.611650485436893 0.6827474585317643 0.4280798303492368 2.9461690553889595 2.0180400455423047 1.030587218054049 0.3284604148463202 0.1425360871812845 1.0 0.3439334989552355 0.0860045321118681 0.1537537642111433 +Psychomotor deterioration 5 9 1.993624575166916 0.0461930976376732 3.2645631067961167 8.910194174757281 0.9753014938956188 0.1960965459818884 1.3866235282600423 0.7031088807706056 1.4929387846379636 0.2609606457365817 1.1945098500891429e-05 0.0017062060788896 0.0065261066260236 0.0031665778749487 1.4142727101836116e-05 +Microcytic anemia 4 7 1.9862501120037688 0.0470055590541069 2.441747572815534 8.526699029126213 0.6645628317552182 0.3838242289014166 1.6704179043327654 1.438636684975842 1.0496853438983738 0.3012783873714112 0.0195192259352808 0.1049896535105009 0.1975594178204269 0.1024964375218493 0.0215080214882775 +Basal ganglia calcification 2 6 1.9842133324101043 0.047232062887498 2.2063106796116503 7.344660194174757 0.7754851929382625 0.4050161590811829 1.490637115556397 1.3943873732460157 0.8989440633592655 0.3080162794814239 0.1691745416852986 1.0 0.2567853086841904 0.5256274046678202 0.1797662267162446 +Furrowed tongue 2 7 1.982051789360026 0.0474734445787976 1.9951456310679612 5.898058252427185 0.740908395172817 0.4209845919293222 1.2941150322346422 1.3862347258142311 0.8556489270277975 0.3009947920089302 0.1467611737455875 1.0 1.0 0.1502583189770621 0.1562329747417322 +Abnormality of lysosomal metabolism 3 5 1.9788593750661927 0.047831841278682 2.0509708737864076 4.776699029126213 0.6001877831871685 0.2139165882109918 1.054267347463803 0.832379194243084 1.5763659100060583 0.2506311014666729 0.0004629533326827 0.0424464003246627 0.003087611696091 0.0009978388997276 0.0005180056018556 +Goiter 2 6 1.9757232540338103 0.0481861297045329 2.6844660194174756 8.25242718446602 0.6101001322888668 0.361705743263382 1.3785638567356056 1.7624367872817217 1.1902904119866486 0.3002320766724904 0.1691745416852986 1.0 1.0 0.0364143419045942 0.1797662267162446 +Vitiligo 2 6 1.9684788981845684 0.0490129617446393 1.75 6.893203883495145 0.5228034908965178 0.4514214081097454 1.549545815072826 0.7902638291080828 0.9503325655279016 0.3007892778972581 0.0778965395269367 1.0 0.1898352204968973 0.4108142183097444 0.0834699588236698 +Difficulty walking 20 76 1.9662753590294568 0.0492668115814833 15.580097087378642 75.13106796116504 0.4697839455005359 0.5877808014506588 5.810176207602449 9.191717769736409 0.8615188656802858 0.3499503569147802 0.0041292737455868 0.2712256519127258 0.3279207405402066 0.004648290892593 0.0056477657303299 +Profound global developmental delay 5 11 1.9649332268395856 0.049421966417275 4.203883495145631 13.509708737864075 0.5052678529667022 0.5184873774632632 1.996887010824457 2.688053923519558 0.8326325920263737 0.3141940376677643 0.0093102627711643 1.0 1.0 0.2453334774508567 0.0106779424109086 diff --git a/msigdb_hp/metrics.json b/msigdb_hp/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..9ff388649f89cc04de86bdea39b3e9fdd70d2d02 --- /dev/null +++ b/msigdb_hp/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2974, + "annotations_size": 4528, + "title": "Average number of proteins per term", + "value": 21.81647526501767 +} \ No newline at end of file diff --git a/msigdb_hp/paths.json b/msigdb_hp/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..3f0775e646d623dc9957ef83189adaf86d504264 --- /dev/null +++ b/msigdb_hp/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/msigdb_hp/fragment/C220/C220_val_log2fc"} \ No newline at end of file diff --git a/msigdb_hp/result.tsv b/msigdb_hp/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..3dcf692e9e8894ca9e8b066e2a5f79c974f146b9 --- /dev/null +++ b/msigdb_hp/result.tsv @@ -0,0 +1,1715 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Dementia 0.5275281665646905 3.5473242091031665 0.0003891653648844 0.8283819212161673 0.3013587472455599 61 P35670,P00403,O96008,P22626,Q9NQZ5,O43681,P00846,P04062,Q9NZJ7,P07602,P17900,Q5JTZ9,Q9Y487,P06865,O76024,P21912,Q13510,P03886,P27544,O15118,Q14108,O60313,Q8IY17 23 +Abnormal activity of mitochondrial respiratory chain 0.5623089590305045 3.342818727860765 0.000829320552147 0.9766397971794696 0.3013587472455599 50 Q9Y2R0,Q9UBX3,P13073,Q8IUX1,O43676,Q9P0J0,Q86Y39,Q70HW3,P21912,O96000,P03886,Q96CU9 12 +Optic disc pallor 0.5343694498853534 3.2011972068379047 0.0013685783046426 0.997972936172276 0.3013587472455599 53 Q86Y39,Q9H061,Q9H3H5,Q10713,Q8WWV3,O96000,P00846,Q9Y6M9,O43676,O95831,Q6P4Q7,Q9UG56,Q96CU9,P51798,Q9H6K4,P03886,Q8IUX1,O60313,Q96S66 19 +Muscle abnormality related to mitochondrial dysfunction 0.5964424176981514 3.1953684991396987 0.0013965240705067 0.998214185274704 0.3013587472455599 35 Q9Y2R0,Q8IUX1,P00846,Q9Y6M9,O43676,O96000,Q86Y39,P00403,P12235,Q9UBX3,P03886,Q96CU9 12 +Abnormal biliary tract morphology 0.6479422370408842 3.153049477290196 0.0016157441870077 0.9993391650969148 0.3013587472455599 24 O43681,P14174,P04062,Q9NZJ7,Q14108,P09601,P07602,Q9NSD9,Q5XKP0,Q13043,Q10713,Q14739 12 +Abnormality of hepatobiliary system physiology 0.4846728846672282 3.140907867781326 0.0016842500674563 0.9995156553464948 0.3013587472455599 76 Q6PGP7,P09622,P35670,Q8N511,Q96A33,Q10713,Q16836,P01889,O75787,O43772,P00846,P04062,P22830,O75381,Q00059,Q9BT22,P50542,Q8TCJ2,P23786,Q6NUQ1,P40939,Q96RP9,Q9Y5Y5,Q13510,O43819,Q9Y619,Q96J02,P03886,Q9NWS8,O15118,Q16625,Q9NSD9,P08574,Q5XKP0,Q13043,O75648,P28288,P40855,P22695 39 +Muscle stiffness 0.6648494942216335 3.1157546738186115 0.001834748421831 0.9997552740380852 0.3013587472455599 20 P53985,P00846,P23786,Q9NZJ7,P07602,Q15392 6 +Mental deterioration 0.4982796975086228 3.0975960482077673 0.0019509716325021 0.9998555573793088 0.3013587472455599 96 O75503,O95470,Q03164,P54802,P35670,P00403,Q10713,P50897,O96008,P16278,Q9NQZ5,P22626,O43681,P00846,P04062,Q9NZJ7,P07602,P17900,Q5JTZ9,Q9BQE5,Q9Y487,P06865,O76024,P21912,Q13510,O43819,P03886,P27544,O15118,Q14108,O60313,Q5XKP0,P21964,Q8IY17 34 +Hyperintensity of cerebral white matter on mri 0.655372893864381 3.0515665449674776 0.0022765058099241 0.9999670252775577 0.3013587472455599 20 O75503,Q9NZJ7,Q15043,P07602,Q96AA3,P17900,P54136,P10253,P21912 9 +Abnormal retinal artery morphology 0.6543520268605739 3.0446224749188295 0.0023297255072454 0.9999741009520686 0.3013587472455599 20 P10619,P00846,Q9NZJ7,Q9Y4P3,P07602,P17900,P21964,Q13510,P16278,P03886 10 +Optic neuropathy 0.637664910369445 3.0386757813626257 0.0023762043277433 0.9999790266256406 0.3013587472455599 23 Q8IUX1,P00846,O43676,Q9P0J0,Q86Y39,O96000,P03886,Q96CU9 8 +Biliary tract abnormality 0.6131211242796599 3.0356656647171 0.0024000533414283 0.999981178366916 0.3013587472455599 27 O43681,P14174,O95202,P04062,Q9NZJ7,Q14108,P09601,P07602,Q9NSD9,Q5XKP0,Q13043,Q10713,Q14739 13 +Horizontal nystagmus 0.6390993642271581 3.010239302333611 0.0026104193263429 0.9999927566964272 0.3013587472455599 22 O14773,P00846,P04062,Q9NZJ7,O60313,Q9NW15,P07602,Q9H061 8 +Blindness 0.4685232263242939 2.9858626979464473 0.0028277957738727 0.999997300374184 0.3013587472455599 73 Q86Y39,Q15058,P50897,O96000,P16278,P00846,Q9Y6M9,O43676,Q9NZJ7,P07602,P17900,Q96CU9,P06865,P49327,P21912,Q9H6K4,O43505,P03886,Q9NZ08,Q8IUX1,P53701 21 +Corneal opacity 0.516674260232068 2.983943676177456 0.0028455914797054 0.9999975099445166 0.3013587472455599 52 P17050,Q9Y4P3,P35670,P16278,P04062,O75381,O75569,O75844,P06280,Q9NVI7,Q9Y5Y5,Q13510,P51648,O43505,P10619,O95202,Q6NUK1,Q06136,P53701,P40855 20 +Bulbar signs 0.778440775828689 2.9793161462151203 0.0028889254015578 0.9999979547402986 0.3013587472455599 13 O43681,P00846,P04062,Q9NZJ7,Q15043,P07602,Q99720,P03886 8 +Ragged red muscle fibers 0.6444934478811479 2.9772656051840265 0.0029083193428152 0.9999981271642538 0.3013587472455599 20 P00846,Q9H2D1,Q9H3H5,Q70HW3,P12235,P03886 6 +Sensorimotor neuropathy 0.5754173804215716 2.968894356043051 0.0029887332908351 0.999998700132168 0.3013587472455599 32 Q9Y2R0,P00846,Q9NR77,Q9NZJ7,O60313,O95831,P07602,Q8N2K0,P40939,P00403,P05023,P03886 12 +Hepatic failure 0.5293130131858039 2.956408038289921 0.0031124503101243 0.999999258916678 0.3013587472455599 48 P50416,Q6PGP7,P09622,P35670,Q10713,Q16836,P01889,O43772,P00846,P04062,P22830,O75381,Q00059,P50542,P23786,Q6NUQ1,P40939,Q96RP9,Q9Y5Y5,Q13510,Q16822,Q9Y619,P03886,Q96J02,O15118,P08574,Q13043,O75648,P28288,P40855 30 +Abnormal choroid morphology 0.6072073113383304 2.944063277244634 0.0032393376228234 0.9999995835623288 0.3013587472455599 26 Q9Y5Y5,Q5XKP0,P40939,Q10713,P53701,O75381,Q8IY17,P40855,Q9Y619,O43505 10 +Abnormal chorioretinal morphology 0.6072073113383304 2.944063277244634 0.0032393376228234 0.9999995835623288 0.3013587472455599 26 Q9Y5Y5,Q5XKP0,P40939,Q10713,P53701,O75381,Q8IY17,P40855,Q9Y619,O43505 10 +Mitochondrial myopathy 0.5985614309473628 2.9251268106641213 0.0034431588205552 0.9999998350338284 0.3013587472455599 27 Q8IUX1,P00846,Q9Y6M9,O43676,Q86Y39,P00403,P12235,O96000,P03886,Q96CU9 10 +Clumsiness 0.6304342542957762 2.9135578723410607 0.0035733559651947 0.9999999087016928 0.3013587472455599 21 O75503,O14773,Q9NR77,Q9NZJ7,P07602,Q15067,P35670,Q13510,O43819 9 +Polyneuropathy 0.6740039550377932 2.9065612945006523 0.0036542529796679 0.9999999367875028 0.3013587472455599 18 Q15041,Q9HC21,Q6PI48,P00846,Q9NZJ7,P31930,O95831,O60313,P07602,Q8N2K0,P35670,P03886 12 +Abnormal circulating lipid concentration 0.4585189563603613 2.8794075883951264 0.0039842304432524 0.9999999858934998 0.3013587472455599 72 Q9UJS0,O95470,P09622,Q15800,Q9Y4P3,Q8N511,Q9NZJ7,P07602,P22830,O75381,Q9UBM7,Q14739,Q15392,P37268,P23786,O75844,P40939,P06280,Q9BV10,Q9NVI7,Q9Y5Y5,P28070,P50402,Q15904,O75880,P40855 26 +Abnormality of the mitochondrion 0.4685374875942719 2.8513084992721436 0.0043539703898098 0.9999999973740464 0.3013587472455599 86 Q9Y2R0,P13073,Q9UMS0,P09622,Q86Y39,P00403,Q70HW3,Q9UBX3,O96000,Q16836,O43772,P00846,Q9Y6M9,O43676,P51970,Q00325,O00483,P11177,P50542,Q96CU9,P23786,Q9P0J0,P40939,Q96RP9,P21912,Q3ZCQ8,P03886,Q8N183,Q8IUX1,P35637,O75880,O75648,P12235,Q4J6C6 34 +Left ventricular hypertrophy 0.6149297357203715 2.8387912000586923 0.0045284778585341 0.9999999988126198 0.3013587472455599 22 O75880,Q6NUK1,P06280,P40939,P00403,P10253,P12235,P21912,O75208,Q07021,P03886 11 +Decreased activity of mitochondrial complex i 0.5558092299881258 2.838682150735701 0.0045300255988076 0.9999999988209496 0.3013587472455599 34 Q9UBX3,Q8IUX1,O43676,Q86Y39,Q70HW3,O96000,P03886,Q96CU9 8 +Peripheral demyelination 0.6998333335284679 2.8368257777287176 0.0045564467731222 0.9999999989544656 0.3013587472455599 16 P07602,P03886,P00846,Q9NR77 4 +Abnormal mitochondria in muscle tissue 0.6132585726321679 2.826807307179169 0.0047014609138511 0.9999999994594398 0.3013587472455599 22 Q8IUX1,O43676,Q86Y39,P00403,O96000,P03886,Q96CU9 7 +Poor head control 0.4531275529057385 2.815746079314669 0.0048664112316052 0.9999999997447814 0.3013587472455599 72 P13073,Q8IUX1,Q9NZJ7,O43676,Q9P0J0,Q86Y39,Q9NWM8,P07602,Q5XKP0,P54136,Q9H3H5,P17900,Q10713,P21912,O96000,P03886,Q96CU9 17 +Disproportionate short stature 0.6007642583236075 2.811005238081368 0.0049386981876837 0.9999999998163204 0.3013587472455599 24 Q96DX4,Q9UBM7,Q03164,Q15392,Q9UHX1,Q9BV10,Q14739,O75718,Q7LGA3,P16278 10 +Action tremor 0.4865051453616445 2.802588912680235 0.0050694240707436 0.9999999998986796 0.3013587472455599 55 Q5JRX3,Q8N2K0,P41440,O43681,P00846,Q9NZJ7,P07602,Q6PJG6,Q99720,O75569,O14773,Q9H6K4,O75027,P03886,Q9NR77,Q14108,P35637,Q9NW15,P54136,Q8IY17 20 +Progressive neurologic deterioration 0.6562962550283625 2.7920028955948126 0.0052382887353874 0.9999999999530206 0.3013587472455599 18 P04062,Q9NZJ7,P54802,P07602,Q5XKP0,Q10713,P21912,P16278 8 +Myoclonic seizure 0.4805886555412298 2.7847332161536937 0.0053571780385361 0.9999999999726557 0.3013587472455599 56 O75503,Q01105,P00846,P04062,Q9NZJ7,P07602,Q5XKP0,Q9H3H5,Q8WWV3,Q13510,P21912,Q9Y619,P03886,Q96N66 14 +Increased csf lactate 0.5039906439633963 2.7810126225599623 0.0054189630126448 0.99999999997936 0.3013587472455599 50 Q9HC21,P13073,Q86Y39,O43464,P36776,P00403,O96000,Q6PI48,P00846,Q9Y6M9,O43676,O95831,P51970,O00483,Q96CU9,Q5T160,Q9P0J0,O43819,P03886,Q8N183,Q9NWS8,Q8IUX1,Q8NI60 23 +Central scotoma 0.8156786469469344 2.7797929236963577 0.0054393571718891 0.99999999998119 0.3013587472455599 10 P00846,Q9H061,Q9H6K4,Q8WWV3,P03886 5 +Abnormality of head blood vessel 0.6045497717047922 2.764080781011527 0.0057083405403812 0.9999999999944732 0.3013587472455599 22 P10619,P00846,Q9NZJ7,Q9Y4P3,P07602,P17900,P21964,Q13510,P16278,P03886 10 +Abnormal circulating cholesterol concentration 0.5566263278613991 2.744408995811575 0.0060619959593464 0.9999999999988962 0.3013587472455599 30 P50402,Q9UJS0,P37268,Q9NZJ7,Q15800,Q15904,P07602,Q8N511,Q9BV10,Q9NVI7,Q14739,Q15392 12 +Abnormality of femur morphology 0.4574171142425455 2.7252539563764913 0.0064252045192727 0.9999999999997892 0.3013587472455599 60 Q96L58,Q96A33,Q9UHX1,Q7LGA3,P16278,Q96DX4,P04062,Q9NZJ7,O95831,P16435,Q96HY6,P07602,P04066,Q14739,O00116,Q32P28,P50542,Q9BXW9,Q96AY3,Q9Y487,O75844,P06280,P51798,Q9BV10,P51812,Q9Y619,O75718,P38646 28 +Abnormality of pulmonary circulation 0.5663570014111673 2.7219185491681945 0.0064904137240477 0.9999999999998432 0.3013587472455599 28 Q9NZ08,P01889,Q8IZA0,Q71SY5,Q9UMS0,P04062,Q14108,O75844,Q6NUK1,P49327,P00403,P51798,O96000,P03886 14 +Mucosal telangiectasiae 0.8034196135537396 2.718905134064355 0.0065498390248839 0.9999999999998804 0.3013587472455599 10 Q8IZA0,P10619,P06280,P21912,Q14739,Q15437 6 +Elevated pulmonary artery pressure 0.5882970854712231 2.7182757767994623 0.0065623117067847 0.9999999999998872 0.3013587472455599 24 P01889,Q8IZA0,Q71SY5,Q9UMS0,P04062,Q14108,O75844,Q6NUK1,P00403,P51798,O96000,P03886 12 +Abnormal csf metabolite level 0.4777453092472922 2.710046607010794 0.0067273754193588 0.9999999999999468 0.3013587472455599 55 Q9HC21,P13073,Q86Y39,O43464,P36776,P00403,O96000,Q6PI48,P00846,Q9Y6M9,O43676,O95831,P51970,O00483,Q96CU9,Q5T160,Q9P0J0,O43819,P03886,Q8N183,Q9NWS8,Q8IUX1,Q8NI60 23 +Hypopigmented skin patches 0.6006140169179454 2.7020180978993644 0.0068920010855089 0.9999999999999748 0.3013587472455599 21 Q8IZA0,Q9NZJ7,P07602,P53701,P21912,P21964,Q15437 7 +Generalized myoclonic seizure 0.5233956042824434 2.6971223388696544 0.0069941569622336 0.9999999999999842 0.3013587472455599 41 Q01105,P00846,P04062,Q9NZJ7,P07602,Q9H3H5,P21912,Q13510,Q9Y619,P03886,Q96N66 11 +Abnormality of alkaline phosphatase level 0.603387699074649 2.6904466393997257 0.0071356445642678 0.9999999999999918 0.3013587472455599 20 Q9UJS0,Q96AY3,Q8N511,Q13043,P51798,Q96A33,Q14739,P22626 8 +Subcutaneous nodule 0.6383887635578809 2.674530215653676 0.0074834032328472 0.9999999999999984 0.3013587472455599 18 Q9NZ08,P17050,P35637,P06280,P49327,P21912,Q13510,Q15437 8 +Abnormal tissue metabolite concentration 0.703463798688706 2.6605371053391385 0.0078016130585665 0.9999999999999996 0.3013587472455599 14 O75381,O43681,Q9NZJ7,P07602,P06280,P17900,Q9Y5Y5,P40855 8 +Respiratory distress 0.5019485944187465 2.6598787674601163 0.0078168782309391 0.9999999999999996 0.3013587472455599 47 P00846,P04062,Q9NZJ7,P23786,P07602,Q00325,P10253,Q9UHX1,P53701,Q13510,O43819,Q9Y619,P51571,P03886 14 +Young adult onset 0.7529408497510319 2.659831613971456 0.0078179726260791 0.9999999999999996 0.3013587472455599 11 O15118,Q9NZJ7,P07602,Q9H0U3,P38435,Q14566 6 +Scotoma 0.7369372417950236 2.6587164659502105 0.0078438943708192 0.9999999999999996 0.3013587472455599 12 P00846,O60313,Q9H061,Q9H6K4,Q8WWV3,P03886 6 +Abnormality of the vasculature of the eye 0.4331850572328749 2.653914222971218 0.0079564049480416 0.9999999999999998 0.3013587472455599 65 Q13510,Q9NZ08,P10619,P00846,Q9NZJ7,Q9NW15,P07602,P17900,P06280,P49327,P38435,Q14739,P28070,P21912,P21964,P16278,P03886,Q96S66 18 +Fluctuations in consciousness 0.8760528780870269 2.626679428381578 0.0086222521111292 1.0 0.3013587472455599 7 O43819,Q9UJS0,P03886,P04062 4 +Increased serum lactate 0.4625866982636401 2.621933252296922 0.0087432552912021 1.0 0.3013587472455599 102 Q53H12,Q5JRX3,P13073,P35610,P09622,Q86Y39,O43464,P36776,P00403,Q70HW3,Q9UBX3,Q6PI48,Q96DA6,P00846,Q9Y6M9,P49411,O95831,P51970,Q00325,O00483,Q5JTZ9,O14949,Q96CU9,Q5T160,Q9P0J0,Q96RP9,P21912,Q3ZCQ8,Q9NVI7,Q07021,O43819,P03886,Q8N183,Q9NWS8,Q8IUX1,Q9BWD1,Q86VD7,O75880,Q5XKP0,P54136,P08574,O75648,Q99797,P12235,Q9BW92,O75208,Q6P4A7,P22695,Q8NI60 49 +Proximal tubulopathy 0.5752574008983353 2.620200781357107 0.008787801060559 1.0 0.3013587472455599 24 Q8IUX1,O43676,Q86Y39,P00403,O96000,P03886,Q96CU9 7 +Progressive visual loss 0.5839936649856142 2.6141588637051107 0.0089447435086784 1.0 0.3013587472455599 22 O75503,O14773,P00846,O60313,P50897,P03886 6 +Abnormal metabolic brain imaging by mrs 0.6625683748707591 2.6079651873364833 0.0091082217017424 1.0 0.3021993820287892 16 P35610,Q9NZJ7,P07602,P21912,O43819,P03886 6 +Abnormal csf protein level 0.7422337914223165 2.6028492539180355 0.0092452594900815 1.0 0.3021993820287892 11 Q9NR77,Q9NZJ7,P07602,P00403,P03886 5 +Abnormal visual electrophysiology 0.4930655234881798 2.5729935517488687 0.0100823086166077 1.0 0.3046834167845001 47 Q53H12,O75503,O43681,P00846,O14773,Q9NZJ7,O60313,P07602,Q15067,O43924,P40939,P51798,P12235,P50897,Q8IY17,Q96S66 16 +Cns demyelination 0.7213020109191118 2.572848900094761 0.010086523303487 1.0 0.3046834167845001 12 Q9NZJ7,P07602,Q15067,P51648,P40855 5 +Hypocholesterolemia 0.843018345890628 2.5489544275066858 0.0108046418337313 1.0 0.3046834167845001 8 P37268,Q9NZJ7,Q15800,P07602,Q9BV10,Q9NVI7 6 +Visual loss 0.498712849407018 2.542176022520332 0.0110164678122219 1.0 0.3046834167845001 44 O75503,O14773,P00846,Q9NZJ7,O60313,P07602,P40939,P00403,P51798,Q10713,P53701,P50897,Q8IY17,P04439,P03886 15 +Ventricular hypertrophy 0.51635056236662 2.530939836957133 0.0113757358994461 1.0 0.3046834167845001 36 O75787,P23786,O75844,O75880,Q6NUK1,P40939,P06280,P00403,P10253,Q9BV10,P21912,O75208,P12235,Q07021,P03886 15 +Abnormal social behavior 0.4237270460258185 2.5278083611973066 0.0114776982718729 1.0 0.3046834167845001 66 O43681,Q8IUX1,Q9Y6M9,O43676,Q9NZJ7,Q9P0J0,Q86Y39,Q9Y4P3,P07602,Q15067,Q5XKP0,P54136,Q9UHX1,O96000,O96008,P03886,Q96CU9 17 +Morphological abnormality of the pyramidal tract 0.5677546432063787 2.527341689446824 0.0114929625763622 1.0 0.3046834167845001 23 Q9H9P8,O00400,P00846,O95831,Q9Y4P3,P35637,O75298,Q9Y619,O75569 9 +Ascites 0.5578289855981864 2.524979582057938 0.0115705011533886 1.0 0.3046834167845001 25 Q8N6S5,O15118,P04062,Q14108,Q9NSD9,Q14739,Q13510,Q00059 8 +Abnormal circulating albumin concentration 0.5469027322285541 2.52107667386976 0.0116996355671683 1.0 0.3046834167845001 27 Q9UJS0,O95470,Q9BT22,Q9NSD9,Q5XKP0,Q13043,Q9BV10,Q00059 8 +Sensory neuropathy 0.5205623966044668 2.5075391374854634 0.0121575117206722 1.0 0.3046834167845001 32 O15269,Q15041,P17050,P00846,O60313,O95831,Q15067,Q8IV08,P00403,P03886,P22626 11 +Focal t2 hyperintense brainstem lesion 0.5958177201000651 2.5068770936765983 0.0121803056491749 1.0 0.3046834167845001 19 Q8IUX1,O43676,Q86Y39,O96000,P03886,Q96CU9 6 +Postural tremor 0.6288035929103593 2.498209826619967 0.0124822286548056 1.0 0.3046834167845001 17 O14773,P00846,Q9NR77,Q14108,Q9H6K4,P03886 6 +Myoclonus 0.4427805286216557 2.492465957069925 0.0126859490893191 1.0 0.3046834167845001 91 O75503,P13073,P17050,Q96AA3,P00403,Q10713,P50897,Q9UBX3,O96008,Q9NQZ5,Q01105,P00846,P04062,Q9NZJ7,P07602,Q96CU9,O14773,Q13510,P03886,Q9NWS8,P27544,Q14108,P00374 23 +Dysesthesia 0.8597155933509351 2.484388802932725 0.0129774031006164 1.0 0.3046834167845001 6 Q9NR77 1 +Increased cerebral lipofuscin 0.914112495789828 2.4841482645348663 0.0129861727192599 1.0 0.3046834167845001 5 Q9NZJ7,O14773,P07602,P50897 4 +Poor eye contact 0.5035321218585258 2.4710675331541117 0.0134710376557263 1.0 0.3059840013107183 39 Q8IUX1,O43676,Q9P0J0,Q86Y39,Q5XKP0,P54136,Q9UHX1,O96000,P03886,Q96CU9 10 +Nephropathy 0.5903356447990784 2.4684983852329654 0.0135681264235161 1.0 0.3059840013107183 19 Q14108,O76024,P00403,Q10713,P03886 5 +Abnormal left ventricle morphology 0.5455195282025938 2.468112289865403 0.0135827703762045 1.0 0.3059840013107183 26 O75787,O75880,Q6NUK1,O75431,P06280,P40939,P00403,P10253,P12235,P21912,O75208,Q07021,P03886 13 +Incoordination 0.423149410177922 2.465102820967132 0.0136973938993383 1.0 0.3070386117633859 71 O75503,O14773,Q01105,P00846,P04062,Q9NZJ7,Q9NR77,P07602,Q15067,Q9H3H5,P12235,P21912,Q13510,O43819,Q9Y619 15 +Decreased activity of mitochondrial complex iv 0.6379792972632523 2.4534361618573928 0.0141498652574072 1.0 0.3156186693868966 16 Q9Y2R0,Q70HW3 2 +Death in infancy 0.4367662189314526 2.439647801244423 0.0147015873080791 1.0 0.3185253908148934 59 Q9HC21,Q9Y5Y5,Q9NWS8,P04062,Q9NZJ7,Q15904,Q6PJG6,P07602,Q6NUK1,Q00059,Q15067,P40855,O75381,O75718,O43819,Q9BT22,P16278 17 +Reduced visual acuity 0.4526435083119255 2.434477881867534 0.0149132912660683 1.0 0.3185253908148934 109 Q86Y39,Q9H061,Q96AA3,Q15058,Q10713,Q9UHX1,Q8WWV3,P50897,Q86YV9,O96000,P16278,O43681,Q71SY5,P00846,Q9NZJ7,O43676,Q9Y6M9,P07602,P17900,Q96CU9,P06865,P49327,Q9H6K4,P21912,O43505,P03886,Q9NZ08,Q8IUX1,O60313,Q15043,P53701,Q96S66 32 +Respiratory failure 0.4183408678583156 2.427709345636902 0.0151945148623848 1.0 0.3229503037175938 63 Q9UMS0,Q92804,Q70HW3,Q9NZJ7,Q8NBU5,Q15165,P07602,Q9BT22,P23786,P40939,P10253,Q13510,O43819,Q9Y619,Q16637,P35637,Q9NSD9,Q5XKP0,P53701 19 +Hypertrophic cardiomyopathy 0.4455273339281259 2.425502289283879 0.0152872193315576 1.0 0.3229503037175938 101 Q53H12,P17050,P09622,Q86Y39,P54802,Q9H061,Q9Y4P3,P00403,P13473,O96000,Q13423,P16278,Q16836,P00846,Q9Y6M9,O43676,Q00325,Q5JTZ9,Q96CU9,Q9P0J0,P06280,P40939,P10253,P21912,Q9NVI7,O43819,P03886,P50402,Q8IUX1,O60313,Q5XKP0,Q99797,P12235,P53701 34 +Abnormal vascular physiology 0.4780620078150641 2.424382763825593 0.0153344335908309 1.0 0.3229503037175938 47 Q9UMS0,Q9Y4P3,P00403,O96000,P01889,Q8IZA0,Q71SY5,P04062,P51970,Q14739,O75844,P06280,P49327,P51798,P03886,Q9NZ08,Q14108,Q9NWM8,Q6NUK1 19 +Abnormal circulating citrulline concentration 0.8974429224532403 2.413041790065674 0.0158200055741897 1.0 0.3236028008772242 5 P03886,Q9Y619,P00846 3 +Loss of speech 0.5819806295791312 2.4096736131625325 0.0159667973129762 1.0 0.3236028008772242 19 O43681,O15118,Q9NZJ7,P07602,P17900,P50897 6 +Abnormal circulating pyruvate family amino acid concentration 0.5807696669493188 2.4011140919464276 0.0163452393790501 1.0 0.3236028008772242 19 Q9UJS0,P00846,Q8IUX1,Q9P0J0,Q5XKP0,Q99797,O96000,P22695,P03886 9 +Arthritis 0.5014005401594485 2.3969556452057073 0.0165319247753414 1.0 0.3254632842728098 36 Q13510,Q9NZ08,P14174,P04062,Q14108,O75844,P35670,P06280,P49327,Q14739,P28070,P10321,P21964 13 +Delusions 0.6128731753146102 2.3937210957206556 0.0166784258395464 1.0 0.3267601900469767 17 Q9UJS0,P04062,Q9NZJ7,Q9BQE5,P07602,P21964 6 +Abnormal conjunctiva morphology 0.5408676103469492 2.392322372034812 0.016742129878732 1.0 0.3267601900469767 25 Q9NZ08,P10619,Q9NW15,P06280,P49327,P21912,Q14739,Q13510,Q15437 9 +Abnormal brainstem mri signal intensity 0.5537469204024873 2.3886736551194256 0.016909315005311 1.0 0.3286067740087908 22 Q8IUX1,Q9Y6M9,O43676,Q86Y39,O96000,P03886,Q96CU9 7 +Infantile axial hypotonia 0.7020665472142992 2.3854676105446937 0.0170574243465284 1.0 0.3290652394661058 11 Q9NZJ7,Q15043,P07602,P17900,Q9H3H5 5 +Emg chronic denervation signs 0.6714413245453015 2.378077384681119 0.0174031732305053 1.0 0.3339049507954582 13 Q9NZJ7,O60313,P07602,Q13510,O43819,P22626 6 +Global brain atrophy 0.5556875025286249 2.373033205835066 0.0176426777394476 1.0 0.3370719190051425 21 Q9H9P8,Q9NZJ7,P07602,Q9H3H5,Q9UHX1,O43819 6 +Unexplained fevers 0.8340433124315998 2.3694732798344673 0.0178134421951436 1.0 0.3375382155349917 6 Q9HC07,P07602 2 +Stroke like episode 0.802432342616689 2.3598586197604847 0.0182819009726795 1.0 0.3375382155349917 8 Q13586,Q96AA3,Q9H3H5,O76024,P00403,P03886 6 +Fever 0.4136941000153555 2.359470292126938 0.0183010461319372 1.0 0.3375382155349917 70 Q13510,Q9NZ08,P35610,P00846,P23786,Q9NZJ7,Q9NR77,Q9HC07,P07602,P06280,P49327,P00403,Q13043,P10253,Q14739,P28070,P51572,P03886 18 +Peripheral axonal neuropathy 0.4413005992115361 2.3562027214131063 0.0184628388934258 1.0 0.3375382155349917 56 O15269,Q9HC21,P17050,P00846,Q9NZJ7,O60313,P07602,Q15067,Q8IV08,O76024,P00403,P12235,Q9NVI7,P03886,Q8IY17,P22626 16 +Lower limb spasticity 0.4183688278328565 2.351245002022674 0.018710709385884 1.0 0.3375382155349917 76 O00400,P00846,P04062,Q9NZJ7,O95831,P07602,Q96CU9,Q9P0J0,Q9H6K4,Q9Y5Y5,P21912,O75298,Q9Y619,Q15041,O60313,Q5XKP0,P54136,Q8IY17,O75477 19 +Skin nodule 0.5507385082564649 2.3360126452292307 0.0194905824972388 1.0 0.3421027755130925 21 Q9NZ08,P17050,P35637,P16615,P06280,P49327,P21912,Q13510,Q15437 9 +Abnormality of retinal pigmentation 0.4115949384502603 2.333378394415526 0.0196282942081227 1.0 0.3421027755130925 70 P00403,P00846,Q13432,O75381,Q6P4Q7,Q9UG56,Q96CU9,Q9P0J0,P40939,O76024,P21912,Q9Y5Y5,P51648,P03886,Q15067,P53701,Q96S66,P40855,Q8IY17 19 +Severe short stature 0.5458083120025881 2.3285067203775873 0.0198852128151043 1.0 0.3421027755130925 22 Q96L58,P48651,P10619,P53701,P21912,Q8IY17,P16278,P38646,Q9Y619,Q15392 10 +Segmental peripheral demyelination remyelination 0.8757122555874836 2.3194746463814764 0.0203693142963263 1.0 0.3421027755130925 5 P03886,P00846 2 +Frequent falls 0.480417618523894 2.317828386450728 0.0204586497118455 1.0 0.3421027755130925 42 P00846,P04062,Q9NZJ7,Q9NR77,P07602,Q9H3H5,P12235,P21912,Q13510 9 +Variable expressivity 0.4173409726077466 2.3167243596330644 0.0205187517343115 1.0 0.3421027755130925 78 Q9NQT5,Q53H12,O95470,P09622,Q9H061,Q9H3H5,Q15058,P00403,Q70HW3,Q9NZJ7,P07602,P17900,P35270,Q13510,P03886,Q9NWS8,Q9NR77,O15121,P54136,Q6P4A7,P00374 21 +Abnormal peripheral myelination 0.516330574693705 2.314878095388261 0.0206196044461335 1.0 0.3421027755130925 28 P00846,Q9NR77,Q9NZJ7,P07602,P03886 5 +Pathologic fracture 0.6750910408026592 2.3137028994068585 0.0206840247493138 1.0 0.3421027755130925 12 O15269,P04062,Q14108,P35670,Q13126 5 +Leukodystrophy 0.4437658083386419 2.3029166580125753 0.0212835327187288 1.0 0.3429602709978798 54 Q8IUX1,Q9Y6M9,O43676,Q9NZJ7,Q9P0J0,Q86Y39,O43819,P07602,Q15067,P54136,P21912,O96000,P03886,Q96CU9 14 +Lacticaciduria 0.8715500047580975 2.301440192933713 0.021366762259003 1.0 0.3430804947119351 5 Q9BQT8,P03886,P00846 3 +Central apnea 0.7892931167201295 2.2977065698287773 0.021578495387279 1.0 0.3452559261964651 8 Q9NZJ7,O76024,P07602 3 +Photophobia 0.4903080758880485 2.296250005675321 0.0216615908433324 1.0 0.3453650821782013 36 Q9NZ08,Q9NZJ7,P04439,P07602,P40939,Q13432,P49327,Q8WWV3,Q86YV9,P51648,Q6P4Q7,Q8IY17,Q96S66 13 +Abnormality of extrapyramidal motor function 0.4134836630491471 2.290524117372627 0.0219909521476953 1.0 0.3480106445269111 76 P35610,P17050,Q96RL7,Q9Y4P3,O43464,O96008,P16278,Q9H9P8,O75787,P04062,Q9NZJ7,P07602,P17900,Q99720,O14949,O75569,P06865,Q6DKK2,P35270,Q9H6K4,P05067,Q15043,P35637,P54136,P12235,P17480 26 +Limb ataxia 0.5279578537718986 2.2899914530168517 0.0220218121164832 1.0 0.3480106445269111 25 O14773,Q9NR77,P04062,Q14108,Q9NW15,Q10713,O75298 7 +Generalized onset motor seizure 0.4418979083512446 2.2824580327907604 0.022462312486706 1.0 0.3480106445269111 54 Q01105,P00846,P04062,Q9NZJ7,P07602,Q9H3H5,P21912,Q13510,Q9Y619,P16278,P03886,Q96N66 12 +Abnormal gallbladder morphology 0.5011821393069821 2.2777218895169167 0.0227431527035786 1.0 0.3480106445269111 30 O43681,P04062,Q9NZJ7,Q9Y4P3,P07602,Q13043,Q96A33,P22830,P21964,P40855,Q15437 11 +Paroxysmal involuntary eye movements 0.5463804605101473 2.2759096576471483 0.0228514173466207 1.0 0.3480106445269111 20 Q8IUX1,O43676,Q86Y39,O96000,P03886,Q96CU9 6 +Cognitive impairment 0.4784305454552258 2.274246476697812 0.022951171261814 1.0 0.3480106445269111 164 Q9Y2R0,O75503,Q9UJS0,Q6PGP7,P17050,O95470,Q03164,P54802,P35670,P00403,Q10713,P50897,O96008,P16278,Q15437,Q9NQZ5,P22626,O43681,P00846,P04062,Q9NZJ7,O95831,P07602,P17900,Q5JTZ9,O75381,O75569,Q9BQE5,Q9Y487,P06280,P35270,O76024,P49327,Q9H6K4,P21912,Q13510,O43819,Q9Y5Y5,Q9Y619,P03886,Q9NZ08,P27544,O15118,Q8N6S5,Q14108,O60313,Q5XKP0,P12235,P21964,P40855,Q8IY17 51 +Impaired vibration sensation in the lower limbs 0.6098582859129428 2.273181212263931 0.023015261999991 1.0 0.3480106445269111 16 O43819,O00400,P00846,Q9NR77 4 +Undetectable electroretinogram 0.8645455981330396 2.2710092330120655 0.023146419021597 1.0 0.3480106445269111 5 O43924,O14773,P50897 3 +Abnormal renal tubule morphology 0.5299022849728995 2.2701428518913325 0.0231989170649806 1.0 0.3480106445269111 24 P00846,P23786,P06280,O43819,P03886 5 +Capillary hemangioma 0.7977680483954461 2.269611354299762 0.0232311741055306 1.0 0.3480106445269111 7 Q8N6S5,P16435,Q9UHX1,Q9UBM7,Q7LGA3 5 +Anophthalmia 0.7977171280107778 2.2693740786215373 0.0232455871365093 1.0 0.3480106445269111 7 O43505,P53701 2 +Abnormal glycosylation 0.5329241315773399 2.260762105039563 0.0237739923674837 1.0 0.3480106445269111 23 P46977,Q9Y487,Q15904,Q96AA3,Q9H3H5,Q9H0U3,Q8N511,Q9BT22,P51571 9 +Emg neuropathic changes 0.5313975205223245 2.24889081308508 0.0245194436423585 1.0 0.3502335672321756 23 O43681,O14773,Q9NR77,Q9NZJ7,O60313,P07602,Q13510,O43819,P22626 9 +Abnormal muscle fiber morphology 0.4035233134845891 2.2436768666619313 0.0248531995813583 1.0 0.3527751965654876 69 Q96RL7,O14979,Q9H3H5,P00403,Q70HW3,O96008,P22626,Q13586,P00846,O43676,O95831,Q9H2D1,O00483,Q99720,P07196,P23786,Q9BTV4,P05067,P03886,P50402,P51114,O60313,P35637,O75648,P12235,P53007,Q8NI60 27 +Abnormal protein glycosylation 0.5577704125066284 2.2369204413670825 0.0252915402930697 1.0 0.356006136459397 19 Q9Y487,Q15904,Q96AA3,Q9H3H5,Q9H0U3,Q8N511,Q9BT22,P51571 8 +Neuronal loss in central nervous system 0.6735934796312737 2.227848434467152 0.0258906237736062 1.0 0.3585099218559305 11 O15118,P04062,Q9NZJ7,P07602,Q6PJG6,O43819 6 +Areflexia 0.4134984287732174 2.225598302253911 0.0260411000225966 1.0 0.3591418765523654 82 O15269,P41440,Q9H3H5,P05023,Q71SY5,O95831,Q9BT22,Q9BQT8,P40939,P10253,Q9H6K4,O43505,Q13510,O43819,Q15041,Q9NWS8,Q9NR77,Q16637,O60313,Q15067,P12235,Q8IY17,P53007,O75477 24 +Dysmetria 0.4433216502365987 2.2247966348717076 0.026094893415576 1.0 0.3591418765523654 52 O75503,Q5JRX3,O43292,Q9Y4P3,Q8N2K0,P20700,P41440,Q10713,O75787,Q6PJG6,Q8IV08,P34897,O14773,Q6DKK2,Q9Y5Y5,O75027,Q9Y3E5,Q8N183,Q12768,O60313,O15121,Q9NW15,P54136,Q96TA2,Q6P4A7 25 +Pedal edema 0.8009595715301958 2.219048961646061 0.0264833937386002 1.0 0.361783793081168 6 P04062 1 +Abnormal circulating non proteinogenic amino acid concentration 0.7724393388177151 2.2173080243024628 0.0266020499318866 1.0 0.361783793081168 8 Q9UJS0,P00846,P51649,Q9Y619,P03886 5 +Ankle clonus 0.6569620812644257 2.2098085336739803 0.0271184532271091 1.0 0.3676417850669169 12 Q9NZJ7,Q15043,P07602,O75298 4 +Increased bone mineral density 0.5219666202533927 2.2074348541424276 0.027283693603358 1.0 0.3687778048835974 24 P04062,Q14108,Q15043,Q9Y4P3,P54802,Q13126,Q15392,Q14739 8 +Rhizomelia 0.6554139636137566 2.200877652238068 0.0277446863999968 1.0 0.369084545362107 12 Q03164,Q9BV10,Q9UBM7,O75718,Q15392,Q14739 6 +Progressive psychomotor deterioration 0.7689808492686212 2.200715654906384 0.0277561598487325 1.0 0.369084545362107 8 Q9NZJ7,P07602,Q10713,P21912,P16278 5 +Areflexia of lower limbs 0.5205989640564422 2.1965830566327256 0.0280502373936966 1.0 0.369084545362107 24 Q13586,Q15041,O75787,Q16637,Q96RL7,Q9NR77,O60313,Q15067,P12235,Q9H6K4,O75477 11 +Abnormal retinal vascular morphology 0.4599544893356039 2.188546574758867 0.0286298125500139 1.0 0.3746699168394889 45 P10619,P00846,Q9NZJ7,Q9Y4P3,P07602,P06865,P17900,P38435,P21964,Q13510,P21912,P16278,P03886,Q96S66 14 +Cherry red spot of the macula 0.73270163074149 2.183479670074268 0.0290005045014356 1.0 0.3762586945057324 9 P10619,Q9NZJ7,P07602,P17900,Q13510,P16278 6 +Progressive spastic quadriplegia 0.7647600287578978 2.180422467221749 0.0292261602395962 1.0 0.378103010185405 8 Q9NZJ7,P17900,P07602 3 +Impaired social interactions 0.4506532535894436 2.174889985028684 0.0296383615937583 1.0 0.381257105956073 48 Q8IUX1,O43676,Q9P0J0,Q86Y39,Q15067,Q5XKP0,P54136,Q9UHX1,O96000,P03886,Q96CU9 11 +Cardiac conduction abnormality 0.4834682015490815 2.1709999208392743 0.0299311783615043 1.0 0.3817663477161563 31 P00846,P23786,Q9H490,P06280,P00403,P21912,O43819,P03886 8 +Disproportionate short limb short stature 0.5486504654052992 2.1709509099592847 0.0299348833636381 1.0 0.3817663477161563 19 Q03164,O75718,Q9BV10,Q9UBM7,O00116,Q7LGA3,Q15392,Q14739 8 +Osteoarthritis 0.6966011546650579 2.168256377434551 0.0301391854658441 1.0 0.3817663477161563 10 P01889,P04062,Q14108,O75844,P35670,P51798 6 +Hypersplenism 0.7755502829132486 2.165456517036879 0.0303527419285094 1.0 0.3817663477161563 7 P04062,Q9NZJ7,Q14108,P07602,P49327 5 +Episodic vomiting 0.6623698899562405 2.164902826660642 0.0303951277043978 1.0 0.3817663477161563 11 P00846,P00403,Q9Y619,P22695,P03886 5 +Ventricular preexcitation 0.7754328784611664 2.1649028029241384 0.0303951295225499 1.0 0.3817663477161563 7 P03886,P00403,P10253,P00846 4 +High frequency sensorineural hearing impairment 0.9095875868137082 2.164359617963981 0.0304367604959214 1.0 0.3817663477161563 4 Q13510,O75844 2 +Abnormal larynx morphology 0.515950286511071 2.159599644893471 0.0308036759467702 1.0 0.3834586623979913 24 Q9NZJ7,P07602,Q9UHX1,P21964,Q13510 5 +Macular degeneration 0.6183186788810242 2.149820233894855 0.0315694370442287 1.0 0.3842645455276017 14 Q13510,P51648,P50897,P04062 4 +Shoulder girdle muscle weakness 0.6592625881588935 2.1473943110677545 0.031761903177411 1.0 0.3844296861800052 11 Q9NZJ7,P12235,P07602 3 +Abnormal circulating proteinogenic amino acid derivative concentration 0.5291264062897351 2.1464423210387276 0.0318377059005083 1.0 0.3844296861800052 20 Q9UJS0,P00846,Q8IUX1,Q9P0J0,Q5XKP0,Q99797,O96000,P22695,P03886 9 +Abnormality of temperature regulation 0.4129487323118149 2.1442448030904595 0.0320132769268768 1.0 0.3855215902257933 89 Q9HC21,P35610,P00403,P00846,Q9NZJ7,Q9HC07,P07602,Q14739,P51572,Q2TAA5,P14174,P23786,P06280,P35270,P49327,P10253,P28070,Q13510,P03886,Q9NZ08,Q9NR77,Q5XKP0,Q13043 23 +Abnormal pericardium morphology 0.755623941218057 2.1363335858315886 0.0326522331892225 1.0 0.3911357457164007 8 Q9NZ08,P14174,P04062,Q14108,P49327 5 +Exercise intolerance 0.4766919379373822 2.1315213906181745 0.033046212129981 1.0 0.3927381851038167 33 Q9Y2R0,Q53H12,Q8IUX1,P23786,Q9H2D1,Q9NSD9,P40939,P00403,P13473,P12235,Q07021,P03886 12 +Abnormal epiphyseal ossification 0.5869253714171734 2.1233471549478486 0.0337247719678783 1.0 0.3958929436023822 16 Q96L58,Q9Y5Y5,Q9UBM7,Q96HY6,P38435,O75381,O00116,P40855,Q9UG56,Q14739 10 +Limb girdle muscle weakness 0.5151067776801146 2.121220070649889 0.0339032870137225 1.0 0.3959239602439207 23 Q9NZJ7,O14979,P07602,Q9H3H5,P12235,Q13126 6 +Underdeveloped supraorbital ridges 0.6544158122576562 2.1200137004550927 0.0340048899223348 1.0 0.3959239602439207 11 O75381,Q6PGP7,Q6NUK1,Q9Y5Y5,P40855 5 +Schizophrenia 0.5720328047861595 2.1199082271735725 0.0340137854538173 1.0 0.3959239602439207 17 P04062,Q9NZJ7,Q9BQE5,P16615,P07602,O76024,P21964 7 +Demyelinating peripheral neuropathy 0.5849570184813441 2.1103673642200627 0.0348267252798897 1.0 0.4022842144575017 16 P03886,P00846,Q9NR77 3 +Spastic paraparesis 0.5199905514272462 2.102457358770162 0.0355132311932442 1.0 0.4070985084633162 21 P04062,Q5XKP0,Q9H6K4,P21912,Q9Y619 5 +Dyschromatopsia 0.7742513192411237 2.0956886839213835 0.0361098163445943 1.0 0.4128920414351592 6 Q9H061,Q9H6K4 2 +Gait ataxia 0.391683508296216 2.0938506945623128 0.0362732826052607 1.0 0.4137164323340571 69 O43681,O14773,O15118,P00846,O43292,Q9NZJ7,Q9NR77,Q14108,Q9NW15,P07602,Q8IV08,Q10713,P12235,Q9NVI7,Q8IY17,P03886 16 +Abnormal pupillary function 0.8239140833994434 2.0924665498540387 0.0363968010008515 1.0 0.4140821983212454 5 P07602,Q9NR77 2 +Chronic fatigue 0.7579170691907002 2.0819011061348323 0.0373515037364451 1.0 0.4169412387667098 7 Q13423,P07602 2 +Splenomegaly 0.3985180781653324 2.0801666943341224 0.0375102459571285 1.0 0.4169412387667098 78 Q6PGP7,P54802,P35670,Q9H0U3,Q96A33,Q10713,P16278,Q15437,P04062,Q9NZJ7,P07602,Q14739,Q9BT22,Q15392,P14174,P49327,P51798,P10253,P28070,Q13510,Q9NZ08,O15118,Q14108,Q15904,Q13043,P21964 26 +Ectopic calcification 0.4299341273240369 2.079527311376873 0.0375689102068943 1.0 0.4169412387667098 52 O75381,Q9Y5Y5,Q9UBM7,P04062,P23786,O60313,O75844,Q9NSD9,P35670,P00403,P38435,Q14739,P40855,P03886 14 +Posterior embryotoxon 0.5935425085638845 2.07712165049941 0.0377903328000104 1.0 0.4183731709497487 15 Q9Y5Y5,Q7LGA3,P53701,O75381,P40855,P21964 6 +Toe walking 0.5190690954286495 2.070104400589276 0.0384425688899563 1.0 0.4219329967656523 20 P50402,O43681,Q9NZJ7,O95831,P35637,P07602,P40939,Q99720,P53007 9 +Abnormality of glycolipid metabolism 0.7553466940850445 2.0696555400761474 0.0384846130000473 1.0 0.4219329967656523 7 O43681,Q9NZJ7,P07602,P06280,P17900 5 +Abnormality of the gallbladder 0.4653131448992069 2.0652232115087905 0.0389018852566149 1.0 0.4225618894906903 36 O43681,Q71SY5,O95202,P04062,Q9NZJ7,Q9Y4P3,P07602,Q13043,Q96A33,P22830,P21964,P40855,Q15437 13 +Headache 0.4004432825507689 2.058089045958542 0.0395815863380002 1.0 0.4230219645168592 60 Q9NZ08,P00846,P23786,P04062,O60313,P49327,P00403,P03886,P12235,P21912,Q8TAA9,Q9NQZ5 12 +Abnormality of epiphysis morphology 0.4248646546052745 2.058052147443327 0.0395851278461563 1.0 0.4230219645168592 53 O75381,Q9Y5Y5,Q96DX4,Q9UBM7,O95202,O95831,P16435,Q9HC07,Q9Y619,P51798,Q9UG56,P38435,Q14739,O00116,P51812,P40855,Q7LGA3,P16278 18 +Peripheral axonal degeneration 0.3887982337812265 2.0570073864189373 0.0396855153641704 1.0 0.4230219645168592 69 O15269,Q9HC21,P17050,Q96RL7,P41440,P00403,P22626,Q6PI48,P00846,Q9NZJ7,O95831,P07602,Q8IV08,Q9UHD9,P34897,Q9BQT8,Q6DKK2,O76024,Q9NVI7,P03886,Q5THJ4,O60313,Q15067,P12235,P17480,Q8IY17 26 +Juvenile onset 0.4556611995623021 2.0568046464813428 0.0397050209628235 1.0 0.4230219645168592 41 Q13510,P50402,O14773,O15118,Q9NR77,P54802,Q9H0U3,P06280,P51649,P51798,Q14566,O75027,Q8IY17,P16278 14 +Saccadic smooth pursuit 0.8831718617785647 2.054169681025415 0.0399592717653427 1.0 0.4247314144447699 4 O14773,Q9NW15 2 +Temperature instability 0.7380941370926555 2.0511120682191124 0.0402560343321805 1.0 0.4267767383851157 8 Q9NZJ7,Q9HC21,P35270,P07602 4 +Progressive sensorineural hearing impairment 0.706091297044786 2.047993011748108 0.0405606841441859 1.0 0.4267767383851157 9 O76024,P00403,P03886 3 +Increased serum pyruvate 0.4674947351000145 2.047716855945964 0.0405877512436771 1.0 0.4267767383851157 33 Q8IUX1,Q9BWD1,O43676,Q86Y39,Q70HW3,P21912,O96000,P22695,P03886,Q96CU9 10 +Avascular necrosis 0.5315876794064764 2.046205667700648 0.0407361399589161 1.0 0.4267767383851157 19 Q9NZ08,P04062,Q14108,O75844,P49327,P51798,Q9Y619 7 +Abnormality of the alveolar ridges 0.763410830993784 2.0451301154646138 0.0408420319641413 1.0 0.4267767383851157 6 O43924,Q15392 2 +Progressive spasticity 0.5884685591042076 2.044484359770661 0.0409057209494567 1.0 0.4267767383851157 15 O43681,Q9NZJ7,O60313,O15121,P07602,P17900 6 +Abnormal light and dark adapted electroretinogram 0.7356402129558387 2.0391167222287483 0.0414383796494659 1.0 0.4284314964481339 8 P00846,P50897 2 +Abnormal full field electroretinogram 0.7356402129558387 2.0391167222287483 0.0414383796494659 1.0 0.4284314964481339 8 P00846,P50897 2 +Mania 0.62759737080295 2.0388258218419497 0.0414674142322573 1.0 0.4284314964481339 12 Q9UJS0,P16615,P00403,P12235,P21964,P03886 6 +Abnormality of chorioretinal pigmentation 0.8791637800474558 2.037347211506656 0.0416152598451169 1.0 0.4284314964481339 4 Q9Y619 1 +Dermal atrophy 0.4924849138482378 2.0371797148200583 0.0416320358739352 1.0 0.4284314964481339 26 Q9NWM8,O75844,Q15392,P53701 4 +Lipoma 0.7610176962964319 2.033931084833148 0.041958544308196 1.0 0.430235974401832 6 Q15437,P21912 2 +Occipital encephalocele 0.8774344080907636 2.030080509379764 0.0423483563524835 1.0 0.4328518229436696 4 O43505,Q6ZXV5 2 +Decreased circulating level of specific antibody 0.8094020594097218 2.0278719925722686 0.0425733142828643 1.0 0.4331954316242918 5 P49327,Q9BV10 2 +Abnormal large intestine physiology 0.5286580216836815 2.0246139369852703 0.0429070220280469 1.0 0.4356120980784678 19 Q9NZJ7,P07602,P06280,Q13043,P21964,Q8TAA9,O75298 7 +Abnormality of skull ossification 0.6248239983348916 2.022504811042918 0.0431242270797764 1.0 0.4368378080922324 12 Q9HC21,P54802,O75844,Q15436,Q6NUK1,Q14739,O75718 7 +Periventricular white matter hyperintensities 0.7314033992809735 2.018368436918903 0.0435529040432893 1.0 0.4377296046938598 8 Q9NZJ7,P17900,O75503,P07602 4 +Chorea 0.3940252993277569 2.0118840227951753 0.0442321639941252 1.0 0.4377296046938598 79 O43681,Q01105,P00846,Q9BWD1,Q9NZJ7,Q71SY5,Q9P0J0,Q86VD7,P07602,Q5XKP0,P17900,P35270,Q9NZ01,Q9H6K4,O43819,P03886,Q96N66 17 +Retinal detachment 0.5830290093133151 2.009364244642361 0.044498519229928 1.0 0.4377296046938598 15 Q8N6S5,Q8NCH0,P49327,Q9BV10,O43505 5 +Abnormality of the gastric mucosa 0.5956522546251793 2.0085949211105603 0.0445801103830609 1.0 0.4377296046938598 14 Q6PGP7,P04062,O76024,P49327,Q14739 5 +Primary adrenal insufficiency 0.6221786305463135 2.006909456836006 0.0447593047236776 1.0 0.4377296046938598 12 Q9Y5Y5,P40855,O75381,Q13423 4 +Paraparesis 0.4843994307732863 2.0059822647623107 0.0448581402385985 1.0 0.4377296046938598 27 P04062,Q5XKP0,Q9H6K4,P21912,Q13510,Q9Y619 6 +Punctate cataract 0.8040373715901042 2.003884826920541 0.0450823992630013 1.0 0.4377296046938598 5 P08670,Q8WWV3,Q9H6K4 3 +3 methylglutaconic aciduria 0.6338832985535119 2.003064903063061 0.0451703225278457 1.0 0.4377296046938598 11 Q53H12,Q96DA6,Q5XKP0,Q9H6K4,Q3ZCQ8,Q9NVI7 6 +Epiphyseal stippling 0.6337662892427114 2.0023940230303863 0.0452423708031639 1.0 0.4377296046938598 11 Q9Y5Y5,Q9UBM7,P38435,O75381,P40855,Q14739 6 +Progressive gait ataxia 0.6211699788949957 2.000956009638993 0.045397130770947 1.0 0.4382904224538346 12 O14773,P00846,Q9NZJ7,Q9NW15,P07602 5 +Focal segmental glomerulosclerosis 0.5245697480101866 1.994398527583486 0.046108519308071 1.0 0.4429174785155125 19 O95470,Q14108,P03886 3 +Psychomotor deterioration 0.6955268829115481 1.9936245751669155 0.0461930976376732 1.0 0.4429174785155125 9 Q9NZJ7,Q03164,Q9Y487,P07602,P50897 5 +Microcytic anemia 0.7379317133855656 1.9862501120037688 0.0470055590541069 1.0 0.4462079064926548 7 Q9BQT8,Q9UBX3,P22830,O75027 4 +Basal ganglia calcification 0.7504282971998657 1.9842133324101043 0.047232062887498 1.0 0.4464230665356872 6 P00403,P03886 2 +Furrowed tongue 0.7370592853545378 1.982051789360026 0.0474734445787976 1.0 0.4469017818145442 7 Q15437,P21912 2 +Abnormality of lysosomal metabolism 0.7984542361918822 1.9788593750661927 0.047831841278682 1.0 0.4479881286908917 5 Q9NZJ7,Q13510,P07602 3 +Goiter 0.7486256139105363 1.9757232540338103 0.0481861297045329 1.0 0.4489440232554016 6 P12235,Q15437 2 +Vitiligo 0.7470887146379196 1.9684788981845684 0.0490129617446393 1.0 0.4519973335635984 6 P00403,P03886 2 +Difficulty walking 0.3878763989058158 1.9662753590294568 0.0492668115814833 1.0 0.4523264835958757 76 Q9HC21,O43292,P35670,Q9H3H5,O43681,Q96DX4,Q71SY5,P00846,Q9NZJ7,P07602,Q99720,O14773,Q13510,O75298,Q15041,Q9NR77,P35637,Q15067,P54136,O75477 20 +Profound global developmental delay 0.6272464341661086 1.9649332268395856 0.049421966417275 1.0 0.4523264835958757 11 O75381,P37268,Q9H490,O60313,Q9Y5Y5 5 +Decerebrate rigidity 0.8599326599326663 1.9562614529200717 0.0504343625885961 1.0 0.4571484518531429 4 Q9NZJ7,P16278,P07602 3 +Neoplasm of the gallbladder 0.8599326599326661 1.9562614529200677 0.0504343625885965 1.0 0.4571484518531429 4 Q9NZJ7,Q13043,P07602 3 +Biliary tract neoplasm 0.8599326599326661 1.9562614529200677 0.0504343625885965 1.0 0.4571484518531429 4 Q9NZJ7,Q13043,P07602 3 +Abnormal brain lactate level by mrs 0.6568340437958711 1.9537704661938 0.0507283684966317 1.0 0.4571484518531429 10 O43819,P03886,P21912 3 +Postaxial foot polydactyly 0.7171761535125176 1.9483470505986056 0.0513734508751346 1.0 0.4571484518531429 8 O43924,Q10713,Q14739 3 +Abnormality of the 5th toe 0.7171761535125176 1.9483470505986056 0.0513734508751346 1.0 0.4571484518531429 8 O43924,Q10713,Q14739 3 +Nasogastric tube feeding in infancy 0.6557298232804928 1.9477411147245756 0.0514459478603785 1.0 0.4571484518531429 10 P07602,Q9UHX1 2 +Generalized hyperkeratosis 0.7913102607392416 1.946746899741239 0.0515650858758298 1.0 0.4571484518531429 5 O75844,Q15437 2 +Meningitis 0.790838666217581 1.9446234971285752 0.0518203091665765 1.0 0.4571484518531429 5 Q8TAA9,Q9NZ08,P01889,P49327 4 +Abnormality of visual evoked potentials 0.5016242125741142 1.9361709962149125 0.052846761484226 1.0 0.4571484518531429 20 O75503,O43681,Q9NZJ7,O60313,P07602,Q15067,P51798 7 +Choreoathetosis 0.4551506845811628 1.934061145781692 0.0531056103577634 1.0 0.4571484518531429 33 P00846,Q9P0J0,Q5XKP0,P35270,Q9H6K4 5 +Increased intracranial pressure 0.5448982225909774 1.9332170203140473 0.0532094689016986 1.0 0.4571484518531429 17 Q9NZ08,Q9NZJ7,P07602,P21912,Q15437 5 +Calcinosis 0.7872665122720974 1.928525252337934 0.0537898263679101 1.0 0.4574607118088171 5 O75844 1 +Brain imaging abnormality 0.4521030730598796 1.9280522956314183 0.0538486217743152 1.0 0.4574607118088171 35 P35610,Q9NZJ7,P07602,Q9H3H5,Q9BV10,P21912,O43819,Q9BT22,P03886 9 +Spastic paraplegia 0.4319124116510559 1.9270110833173144 0.053978248705274 1.0 0.4577032025046455 46 Q15041,O00400,P00846,P04062,O60313,Q9P0J0,Q8IY17,O75298,Q9Y619,Q96CU9 10 +Fetal distress 0.4790142146320392 1.9244115568343805 0.0543030169878246 1.0 0.4595963755530284 26 Q8IUX1,Q9Y6M9,O43676,Q86Y39,O96000,P03886,Q96CU9 7 +Clonus 0.4550221465786886 1.9231419377954224 0.0544622267365317 1.0 0.4600838855653282 32 O00400,P20700,Q53FT3,O75787,Q9NZJ7,Q6PJG6,P07602,Q99720,Q9BQT8,Q3ZCQ8,O75027,O75298,Q9Y619,Q12768,Q15043,P35637,Q9NW15,Q9Y3C8,O75477 19 +Hypothermia 0.711428923435276 1.919909858801698 0.054869286409267 1.0 0.4616465418812484 8 P03886,P00846 2 +Pericardial effusion 0.8512010532774221 1.9192471206106216 0.0549530667124542 1.0 0.4616465418812484 4 P04062 1 +Neoplasm of fatty tissue 0.6808712621893229 1.9176602669556904 0.055154102942813 1.0 0.4624773668982549 9 Q15437,P21912 2 +Abnormality of corneal stroma 0.6067568271858584 1.9154576955283364 0.0554341592866269 1.0 0.4639664939923234 12 P10619,P04062,O43505,Q13510,P16278 5 +Visual field defect 0.4410132540784527 1.9124584726390137 0.0558174142118756 1.0 0.4656462287557911 41 Q9Y5Y5,P00846,O60313,Q9H061,P00403,Q9H6K4,Q8WWV3,O75381,P03886 9 +Hypolipoproteinemia 0.722617174094953 1.9122781558798712 0.0558405261074193 1.0 0.4656462287557911 7 Q15800,P37268 2 +Abnormal circulating long chain fatty acid concentration 0.7829944330901077 1.9092398088826197 0.0562311630598679 1.0 0.4680417395865481 5 Q9Y5Y5,O75381,P23786 3 +Abnormal electroretinogram 0.4531474568864629 1.9058755036939985 0.0566663599391321 1.0 0.4700169471458661 32 O14773,P00846,Q15067,O43924,P40939,P12235,P50897,Q8IY17,Q96S66 9 +Recurrent aspiration pneumonia 0.7822334304534795 1.9058006714112896 0.0566760718068999 1.0 0.4700169471458661 5 Q13510,P04062 2 +Retinal telangiectasia 0.7819460013592343 1.9045014228111037 0.0568449115421128 1.0 0.4705553189445827 5 P00846 1 +Lower limb pain 0.7328813540425523 1.9012493917019255 0.0572693544191018 1.0 0.4723417792526288 6 O75569,P00846 2 +Abnormal nephron morphology 0.3938746513200706 1.891386024105316 0.0585728328371739 1.0 0.4775100424369931 58 Q9NZ08,P00846,P23786,O95470,Q14108,P06280,P49327,P00403,P21912,O43819,P03886 11 +Erlenmeyer flask deformity of the femurs 0.8437710437710583 1.887655067463644 0.0590722721743939 1.0 0.479353491766408 4 Q9NZJ7,P07602,P04062 3 +Proportionate short stature 0.45108207601848 1.88681733620816 0.0591848985390914 1.0 0.47940826580502 32 Q96L58,Q16836,P48651,P10619,P40939,Q15392,P53701,P21912,Q14739,Q8IY17,P38646,Q9Y619,P16278 13 +Fibrous tissue neoplasm 0.524073776331165 1.8841200234492832 0.0595487423310181 1.0 0.4808325627324305 18 Q96DX4,P21912,Q13126,Q15392,Q15437 5 +Impaired vibratory sensation 0.456580264038962 1.8839398238638596 0.0595731156565577 1.0 0.4808325627324305 30 O00400,O14773,P00846,Q9NR77,O43819,Q9Y619 6 +Abnormal intraocular pressure 0.7758013380591686 1.876687734830248 0.060560904642767 1.0 0.4868378811047169 5 Q8NCH0,Q15043 2 +Bile duct proliferation 0.8411156441739673 1.8763434776322936 0.0606081305345103 1.0 0.4868378811047169 4 Q5XKP0 1 +Abnormal cardiac ventricular function 0.5359941757288227 1.871130976688732 0.0613269289415776 1.0 0.4882670642678259 17 O75844,P00403,P12235,P21912,P03886 5 +Gastrointestinal hemorrhage 0.4726611444922398 1.8707631234652593 0.0613779210680904 1.0 0.4882670642678259 26 Q9NZ08,Q9UJS0,O76024,Q9UHX1,P21912,Q14739,P21964 7 +Chorioretinal dysplasia 0.7262653210957808 1.869782690624914 0.0615140010101038 1.0 0.4882670642678259 6 P53701 1 +Impaired proprioception 0.4398830400855352 1.866918084526637 0.061913027994944 1.0 0.4882670642678259 39 O00400,O14773,P00846,Q9NR77,P54802,Q9H6K4,O43819,O75298,Q9Y619 9 +Abnormal midbrain morphology 0.6711005705895354 1.8666701011958833 0.0619476714939914 1.0 0.4882670642678259 9 O43924,P04062 2 +Fasciculations 0.4422450530751323 1.8601474051649016 0.0628646738215392 1.0 0.4882670642678259 37 Q9BQT8,Q9NQT5,Q9NWS8,Q16637,Q9NZJ7,Q8NBU5,O95831,P35637,Q9NW15,P07602,P06280,Q13510,O43819,P22626 14 +Retinal dysplasia 0.699151692544633 1.858873550234866 0.063045064000387 1.0 0.4882670642678259 8 O43924,P53701,O43505 3 +Slender long bone 0.5719630089793513 1.8586244043470537 0.0630803954465359 1.0 0.4882670642678259 14 Q96DX4,P37268,Q9H490,Q9Y487,Q9Y619,Q96J02,Q32P28 7 +Rigidity 0.4040396959631059 1.8584883365860845 0.0630996981615867 1.0 0.4882670642678259 54 P00846,P04062,Q9NZJ7,P07602,P35270,P12235,Q9H6K4,Q15392 8 +Abnormality of krebs cycle metabolism 0.77165234621332 1.857866281906666 0.0631880056780822 1.0 0.4882670642678259 5 P00846 1 +Mitochondrial inheritance 0.771586359945369 1.8575666764344811 0.0632305744067327 1.0 0.4882670642678259 5 P03886,P00846 2 +Abnormal circulating copper concentration 0.7234940230142125 1.8565722660594697 0.0633720327403015 1.0 0.4882670642678259 6 O43819,Q9Y487,Q15904 3 +Babinski sign 0.3878274256152288 1.855833562604208 0.0634772850729643 1.0 0.4882670642678259 86 O00400,Q8N2K0,P41440,Q6PI48,O43681,O75787,P00846,Q9NZJ7,O95831,P07602,Q6PJG6,O00483,Q99720,P34897,O14773,P40939,Q6DKK2,Q9H6K4,P21912,O75027,O75298,P51812,Q5THJ4,Q9NR77,O60313,O15121,Q15043,P35637,Q15067,Q8IY17,O75477 31 +Lactic acidosis 0.3860833109496062 1.8549709843703877 0.0636003701470497 1.0 0.4882670642678259 84 Q9HC21,Q53H12,Q9UJS0,Q9UMS0,P09622,Q86Y39,P36776,P00403,Q70HW3,Q10713,O96000,Q16836,Q9Y6M9,O43676,P49411,P51970,Q00325,Q5JTZ9,P11177,Q96CU9,P40939,O43819,P03886,Q8N183,Q9NWS8,Q8IUX1,Q86VD7,Q5XKP0,P08574,O75648,Q99797,P12235,O75208,Q6P4A7,Q8NI60,Q4J6C6 36 +Centrocecal scotoma 0.835704863119688 1.853260691631184 0.0638450023821242 1.0 0.4882670642678259 4 P03886,P00846 2 +Hyperactive patellar reflex 0.7103793398144096 1.8527522802797052 0.0639178728186389 1.0 0.4882670642678259 7 P13073,P21912 2 +Adult onset 0.3705962978439735 1.844700728153067 0.0650810849046255 1.0 0.4922171873403924 67 P17050,O14979,O95453,P20700,P41440,Q9H0U3,Q9NQZ5,Q13586,P43304,Q71SY5,P04062,P31930,Q9NZJ7,Q9UGP8,P07602,Q8IV08,Q9UHD9,P38435,Q14566,Q9BTV4,O76024,P51649,P21912,Q07021,Q12768,Q5THJ4,P18031,O15118,Q16637,P12235 30 +Endocarditis 0.768327044347381 1.842757705713061 0.0653643945097139 1.0 0.4922171873403924 5 Q9NZ08,P49327,P04062 3 +Poor wound healing 0.7672832384287789 1.8380108311710124 0.0660608093028642 1.0 0.4922171873403924 5 P04062 1 +Lower limb hypertonia 0.6354730310720027 1.8364375772228472 0.0662929662956954 1.0 0.4922171873403924 10 Q14739,O00400,P21912 3 +Titubation 0.6348957708743255 1.8332465777419436 0.0667659100129487 1.0 0.4922171873403924 10 Q5JRX3,Q96RL7,P35637,Q6PJG6,P20700,Q99720 6 +Retinal arterial tortuosity 0.9687079407806204 1.8321903657287593 0.0669230637389586 1.0 0.4922171873403924 2 P00846 1 +Leber optic atrophy 0.9687079407806204 1.8321903657287593 0.0669230637389586 1.0 0.4922171873403924 2 P00846 1 +Low plasma citrulline 0.9687079407806204 1.8321903657287593 0.0669230637389586 1.0 0.4922171873403924 2 P00846 1 +Multiple glomerular cysts 0.9687079407806204 1.8321903657287593 0.0669230637389586 1.0 0.4922171873403924 2 P00846 1 +Abnormal cranial nerve physiology 0.3696362064257747 1.8321526483621928 0.0669286813307876 1.0 0.4922171873403924 67 P48651,Q9H3H5,Q9UHX1,P01889,Q9NZJ7,P07602,O95155,O75381,P50542,P34897,Q9BXW9,P07196,P49327,P51798,P21912,Q9Y5Y5,Q13510,P51812,O43819,Q9Y3E5,Q9NZ08,Q9NR77,Q15043,P12235,P40855,P53007 26 +Phenotypic variability 0.3973366580766553 1.830991208277762 0.0671018553329074 1.0 0.4924427892178363 100 Q9NQT5,Q53H12,O95470,P09622,O14979,Q9H061,Q9H3H5,Q15058,P00403,Q70HW3,P00846,Q9NZJ7,P07602,P17900,P35270,P21912,Q13510,P03886,Q9NWS8,Q9NR77,O60313,O15121,P54136,Q6P4A7,P00374 25 +Thyroiditis 0.7177331496672165 1.8290551407689957 0.0673913482243289 1.0 0.4937670303556008 6 Q13043,P49327,Q15437 3 +Mitral valve calcification 0.8291124465711368 1.825076694421831 0.0679894565671297 1.0 0.4956550969274576 4 P04062 1 +Cardiac valve calcification 0.8291124465711368 1.825076694421831 0.0679894565671297 1.0 0.4956550969274576 4 P04062 1 +Abnormal protein o linked glycosylation 0.8280509365850828 1.820532403017873 0.0686779663466379 1.0 0.4983554993871418 4 Q8N511 1 +Easy fatigability 0.4766063911443879 1.8122961090925287 0.0699404554461986 1.0 0.5058951793296924 23 Q53H12,Q8IUX1,Q9NWM8,Q9H3H5,P12235,P21912,P53007 7 +Diffuse cerebral atrophy 0.5137787881851931 1.8094279680328953 0.0703845414081578 1.0 0.5082953803766169 18 O75787,Q9NZJ7,P07602,P54136,Q9H936,Q10713,P16278 7 +Cavernous hemangioma 0.7606149281816403 1.8076373291087589 0.0706629644126886 1.0 0.5087415542663345 5 Q15437 1 +Telangiectasia 0.4401801727499115 1.804266528525205 0.0711895343148587 1.0 0.5100414736988614 34 Q8IZA0,P10619,P00846,Q8N6S5,P06280,Q13043,P21912,Q14739,P03886,Q15437 10 +Myositis 0.6880660585580705 1.8034274786902709 0.0713211053385558 1.0 0.5101768798941246 8 P28070,Q9NZ08,P49327,P22626 4 +Emg abnormality 0.3708784088190615 1.802299875916632 0.071498238055724 1.0 0.5106372585430894 71 O15269,Q9H3H5,P13473,P22626,Q13586,O43681,Q9NZJ7,P07602,O14773,Q9BTV4,Q13510,O43819,P50402,P42167,Q16637,Q9NR77,O60313,Q9NW15,P12235,P53007,Q8NI60 21 +Mandibular aplasia 0.9606325706594891 1.7981007395089987 0.0721610450814465 1.0 0.5145593891791964 2 Q9Y619 1 +Negativism 0.9599596231493952 1.79525755406695 0.0726126744022579 1.0 0.5160454462646202 2 Q9BQE5 1 +Social and occupational deterioration 0.9599596231493952 1.79525755406695 0.0726126744022579 1.0 0.5160454462646202 2 Q9BQE5 1 +Retinal coloboma 0.686288997741845 1.7945102249321705 0.0727317680700223 1.0 0.5160454462646202 8 Q9UHX1 1 +Spastic gait 0.4706595377550089 1.7913609274089073 0.0732353947457635 1.0 0.5181404178262773 24 Q15041,O00400,Q15043,Q9NVI7,O75298,Q9Y619 6 +Joint swelling 0.7088487025789093 1.786472081766039 0.0740228536608622 1.0 0.5220801890597886 6 P35670,Q13510 2 +Aortic valve stenosis 0.6963525900652696 1.7840804461009878 0.074410594155994 1.0 0.5239987097019301 7 O75844,P04062 2 +Muscle spasm 0.3779056257317601 1.7815101527213857 0.0748291477877427 1.0 0.5244992368281853 60 P09622,Q9H3H5,Q92804,P13473,P05023,Q13586,P00846,P04062,Q15165,P53985,P23786,P40939,P06280,Q9H6K4,O75298,Q16637,Q9NR77,P35637,P12235 19 +Paraplegia paraparesis 0.3719012089516145 1.7815099824901246 0.074829175572219 1.0 0.5244992368281853 74 Q15041,O00400,P00846,P04062,O60313,Q9P0J0,Q5XKP0,Q9H6K4,Q9Y5Y5,Q13510,P21912,O75298,Q9Y619,Q8IY17,Q96CU9 15 +Abnormal placenta morphology 0.6830998715199769 1.778487301579483 0.0753238556892024 1.0 0.526035394833713 8 P16278,O75844 2 +Abnormality of the clitoris 0.5089766535019016 1.7743937678503925 0.0759980400017454 1.0 0.526035394833713 18 O75381,P16435,P53701,Q9Y5Y5,P40855,Q9Y619 6 +Focal t2 hyperintense basal ganglia lesion 0.4949383241554356 1.7724831116912994 0.0763143962747296 1.0 0.526035394833713 19 P03886,P00846,Q96CU9 3 +Pericarditis 0.8168350168350165 1.7724159852388597 0.0763255302151351 1.0 0.526035394833713 4 Q9NZ08,P14174,P49327 3 +Abnormality of the cerebrospinal fluid 0.416335730068352 1.7648210018156745 0.0775938538140066 1.0 0.526035394833713 132 Q96L58,Q9HC21,P48651,P13073,Q86Y39,O43464,P36776,P00403,Q10713,O96000,Q6PI48,O43681,P00846,P04062,Q9H490,O43676,Q9NZJ7,P51970,Q9Y6M9,O95831,P07602,P16435,O00483,Q9UBM7,Q15392,Q96CU9,Q5T160,Q9BXW9,P23786,Q9P0J0,Q9NRZ9,P51798,Q96RP9,O43505,O60508,O43819,Q8TAA9,P03886,Q8N183,Q9NWS8,Q8IUX1,O95202,Q9NR77,Q16625,Q6NUK1,P53701,P21964,P40855,Q8NI60 49 +Glomerulopathy 0.6224835005698315 1.7643809301060516 0.0776678666153911 1.0 0.526035394833713 10 P06280,Q14108,Q9NZ08,P49327 4 +Infantile muscular hypotonia 0.3626710347835818 1.7640607631055316 0.0777217495488773 1.0 0.526035394833713 65 P00846,Q9NZJ7,Q9Y487,Q15043,P07602,P54136,Q9H3H5,P17900,Q13510,O43819,P16278,P03886 12 +Memory impairment 0.4366717237882317 1.7614135817711942 0.0781684279158148 1.0 0.526035394833713 33 Q9NZ08,Q9UJS0,Q9NZJ7,P07602,P49327,P00403,O96008,P03886 8 +Aplasia hypoplasia of the patella 0.8134036491755083 1.7576590533819398 0.0788055388636923 1.0 0.5294235607934702 4 Q9Y619 1 +Raynaud phenomenon 0.7023992620215085 1.7554506795160556 0.0791822498534706 1.0 0.5304989487345854 6 O75844 1 +Dilated cardiomyopathy 0.4283515523511788 1.753344010413579 0.0795429753834187 1.0 0.5304989487345854 39 Q16836,P42167,Q96DA6,P00846,P23786,P40939,P00403,P13473,P12235,P53701,O95155,O43819,P16278,P03886 14 +Abnormal sternum morphology 0.3894075409930336 1.7490790704372738 0.0802773524933031 1.0 0.533767771056794 98 Q03164,Q9Y4P3,P55795,Q96A33,Q9UHX1,Q7LGA3,P16278,Q15437,Q96DX4,Q71SY5,P04062,Q9H490,O95831,Q14739,Q8NCH0,Q96AY3,Q9Y487,P21912,Q9NVI7,Q13510,P51812,Q9Y619,Q96J02,P50402,O95202,Q9NSD9,O75718 27 +Adrenal insufficiency 0.4716880681195003 1.7465844765773937 0.0807094418621849 1.0 0.5347156666485097 22 O75381,O95470,P40855,Q9Y5Y5,Q13423 5 +Left ventricular systolic dysfunction 0.7004820693497089 1.7462116200713012 0.0807741863930169 1.0 0.5347156666485097 6 O75844 1 +Abnormality of prothrombin 0.5780940085647603 1.743099134383683 0.0813162998024799 1.0 0.5372622456608872 12 Q9UJS0,Q5XKP0,P40939,Q13043,Q9BV10,P38435 6 +Pigmentary retinopathy 0.4164698146684621 1.7426419388276189 0.0813961794442068 1.0 0.5372622456608872 45 P00846,Q9P0J0,Q96S66,Q15067,O76024,P00403,P53701,P21912,Q9UG56,P03886,Q96CU9 11 +Bone pain 0.4766024314315051 1.7407404626888343 0.0817290822633434 1.0 0.537891401872702 20 P04062,Q9NZJ7,Q14108,P07602,P35670 5 +Papule 0.4900634428363352 1.7354916987064497 0.0826537505907574 1.0 0.5400522116521639 19 Q9NZ08,O75844,P16615,P49327,P38435,P21912,Q15437 7 +Hyperesthesia 0.9438088829071358 1.7269194788138098 0.0841821256165729 1.0 0.5468818720112512 2 P07602 1 +Supernumerary tooth 0.6953815002830724 1.7215931433040743 0.0851432461495396 1.0 0.5485550408638226 6 Q9UHX1 1 +Spastic tetraparesis 0.4654939160114187 1.7212784834310495 0.085200301982439 1.0 0.5485550408638226 23 Q9NZJ7,P07602,P17900,P00846 4 +Abnormality of the biliary system 0.3943093851083493 1.7206089228588872 0.0853218132145747 1.0 0.5485550408638226 107 Q9UJS0,Q6PGP7,Q9Y4P3,P35670,Q9H3H5,Q96A33,Q10713,Q15437,O43681,Q71SY5,P04062,Q9NZJ7,P07602,P22830,O75381,Q14739,Q9UBM7,Q00059,P14174,P40939,Q9Y5Y5,Q13510,O15118,O95202,Q14108,Q15904,P09601,Q9NSD9,Q5XKP0,Q13043,P21964,P00374,P40855 33 +Pleural effusion 0.6433584069667216 1.7204191182718531 0.0853562842513064 1.0 0.5485550408638226 9 Q9NZ08,P14174,Q13043,P49327,Q14739 5 +Abnormal enchondral ossification 0.4586448221329957 1.7201297620778495 0.0854088568482762 1.0 0.5485550408638226 25 Q96L58,Q9Y5Y5,Q9UBM7,O95202,Q96HY6,Q9Y619,P36776,P38435,O75381,O00116,P40855,Q9UG56,Q14739 13 +Vascular skin abnormality 0.3955535193558177 1.7166797714476885 0.0860376981603268 1.0 0.5508323269431359 109 P17050,P35670,P00403,P07858,Q13126,Q86YV9,P16278,Q15437,Q8IZA0,P00846,P04062,P22830,P38435,Q14739,Q9UBM7,Q8NCH0,Q9Y487,O75844,P06280,P49327,P51798,P21912,P51648,P03886,P10619,Q8N6S5,Q14108,Q9NWM8,Q6NUK1,Q06136,Q13043,P53701,P21964 33 +Cerebral white matter atrophy 0.5010343521902955 1.716183969857966 0.0861283762093065 1.0 0.5508323269431359 18 Q9H9P8,O75503,O60313,Q9Y5Y5,P51572,Q2TAA5 6 +Hand polydactyly 0.4463204738649979 1.7126874128557583 0.0867700620344749 1.0 0.5522482102759944 28 O95202,Q15067,O43924,Q10713,Q9UHX1,P21964,Q8IY17,Q14739 8 +Abnormal pyramidal sign 0.4050111115538916 1.7122417343350826 0.0868521292893 1.0 0.5522482102759944 122 O75477,O00400,P17050,Q8N2K0,P41440,Q9H9P8,Q6PI48,P01889,O75787,O43681,P00846,Q9NZJ7,O95831,P07602,Q6PJG6,P17900,O00483,P04066,Q99720,P51572,O75569,P34897,O14773,Q9P0J0,P40939,Q6DKK2,P49327,Q9H6K4,P21912,P51648,O75298,Q9Y619,O75027,P51812,Q9NZ08,Q5THJ4,Q9NR77,O60313,O15121,Q15043,P35637,Q15067,P17480,Q8IY17,Q8NI60 45 +Abnormality of the shoulder girdle musculature 0.4376327793752158 1.7116450883545884 0.0869620937791548 1.0 0.5522482102759944 30 P50402,Q9NZJ7,Q9Y487,O14979,P07602,Q9H3H5,P12235 7 +Abnormal b cell morphology 0.6816580702518886 1.7116433448816029 0.0869624152735328 1.0 0.5522482102759944 7 Q13432,Q9BV10 2 +Osteopenia 0.3657082293837888 1.7115568631834528 0.0869783636015841 1.0 0.5522482102759944 73 Q96DX4,P17050,Q9H490,O43292,Q9NZJ7,P04062,Q9Y487,Q96AY3,O75844,P07602,Q14108,Q9NWM8,Q9NSD9,Q13043,Q13126,O75718 16 +Elevated hepatic transaminase 0.3840698101214034 1.7109976751990013 0.0870815419914001 1.0 0.5522482102759944 95 Q9UJS0,Q96RL7,P09622,Q8N511,Q9H3H5,P35670,Q10713,Q16836,P01889,O75787,Q96DA6,Q9HC07,Q14739,Q00059,Q2TAA5,P23786,P40939,P10253,Q9BV10,Q9Y5Y5,Q13510,Q07021,P28070,Q9Y619,Q16625,Q15904,Q15067,Q5XKP0,Q9NSD9,Q13043,O75648,O75880,P08574,P12235,P28288,P40855,P22695 37 +Neck muscle weakness 0.5608833156003588 1.7087959147973717 0.087488759724472 1.0 0.553606405570416 13 Q9NZJ7,P35637,P07602,Q99720,P53007 5 +Confusion 0.5129384538345545 1.7085181826054443 0.0875402355098096 1.0 0.553606405570416 17 Q16836,Q9NZ08,P01889,Q9UJS0,P40939,P49327,O96008,Q9Y619 8 +Abnormal talus morphology 0.4998463615071494 1.7074488712241305 0.0877386533331103 1.0 0.5540873393198379 18 Q15058,O75844,Q96DX4,Q9UHX1 4 +Abnormal heart rate variability 0.8013824676579735 1.7058312167814076 0.0880395091812435 1.0 0.5552129492655585 4 P07602 1 +Color vision defect 0.5357538257352801 1.69851180134555 0.0894112072326462 1.0 0.5582717845378654 15 O60313,Q9H061,Q13432,Q9H6K4,Q8WWV3 5 +Slow decrease in visual acuity 0.667226928525581 1.6983622753695888 0.0894394075883779 1.0 0.5582717845378654 8 P00846 1 +Resting tremor 0.4680980741737679 1.6944351024053534 0.0901826339792744 1.0 0.5609161629919704 21 Q9H6K4,P12235,P07602,P04062 4 +Tinnitus 0.5462523873955075 1.6931802535420355 0.0904211620407717 1.0 0.5613041009517035 14 P17050,Q9NR77,Q15043,P21912,Q9NR28 5 +Ophthalmoparesis 0.3572784002127188 1.6928032100863608 0.0904929314696871 1.0 0.5613041009517035 65 P00846,P04062,Q9P0J0,O76024,P00403,P12235,P21912,O43819,P03886,Q96CU9 10 +Cardiovascular calcification 0.6655485116019653 1.689853829220063 0.0910559225542979 1.0 0.5634098574229404 8 P04062 1 +Abnormal thoracic spine morphology 0.4514728264989905 1.6897213562258484 0.0910812755374541 1.0 0.5634098574229404 26 P04062,O95831,O75844,Q9UHX1,P51648,O75477 6 +Ketotic hypoglycemia 0.9347240915208624 1.688401506464861 0.0913341814959523 1.0 0.5635768244572064 2 Q13423 1 +Hyperventilation 0.7972718838791855 1.6880640351004732 0.0913989373672199 1.0 0.5635768244572064 4 P00846 1 +Abnormal size of the clitoris 0.5340350823071549 1.687025523214015 0.0915984443283506 1.0 0.5635768244572064 15 Q9Y5Y5,P16435,P53701,O75381,P40855,Q9Y619 6 +Abnormality of the tongue 0.371508676382108 1.686813968256299 0.0916391287129727 1.0 0.5635768244572064 82 Q9NQT5,P48651,Q96RL7,Q9Y4P3,P20700,Q96A33,Q10713,Q7LGA3,P16278,Q15437,P01889,Q71SY5,O95831,O43924,P04066,O75381,Q9UBM7,P50542,Q9BQT8,P07196,O75844,Q9NRZ9,P49327,P10253,P21912,Q9Y5Y5,Q13510,Q9NWS8,P51114,Q16637,Q6NUK1,O75648,O75431,P40855 34 +Pulmonary infiltrates 0.6872325396941087 1.6821467186125054 0.092540392996633 1.0 0.5677817066243287 6 Q13510,Q9NZ08,P49327,P04062 4 +Disproportionate short trunk short stature 0.6868072555041349 1.680084246155698 0.0929409255729476 1.0 0.5692615658032738 6 Q96DX4,Q9UHX1 2 +Echolalia 0.6353803584358639 1.6779686556491684 0.0933532181876035 1.0 0.5692957730197714 9 P53701,Q9UHX1 2 +Abnormal pupillary light reflex 0.9441265567149072 1.6767584773027493 0.0935897203881241 1.0 0.5692957730197714 3 P07602,Q9NR77 2 +Slow pupillary light response 0.9441265567149072 1.6767584773027493 0.0935897203881241 1.0 0.5692957730197714 3 P07602,Q9NR77 2 +Abnormality of female external genitalia 0.4291148666512978 1.6747267059286302 0.0939878651375989 1.0 0.5692957730197714 31 Q9Y5Y5,P16435,Q6NUK1,P53701,O75381,P40855,Q9Y619,Q15392 8 +Very long chain fatty acid accumulation 0.6854644810387799 1.6735698281405411 0.0942151723886672 1.0 0.5692957730197714 6 Q9Y5Y5,O75381,P40855,P50542 4 +Limb pain 0.605716435404144 1.6706030601757125 0.0948001076516369 1.0 0.5692957730197714 10 O15269,O75569,P00846 3 +Personality changes 0.5197434643121447 1.669795264017934 0.0949598777380971 1.0 0.5692957730197714 16 P00403,Q8IY17,P03886,P04062 4 +External ophthalmoplegia 0.5195291460037591 1.668314611926795 0.0952532887770767 1.0 0.5692957730197714 16 Q13586,O60313,P00403,P12235,P21912,Q07021,P03886 7 +Hypomimic face 0.5544053149668366 1.6680705541908132 0.0953017217201825 1.0 0.5692957730197714 13 P35270,P12235,P04062 3 +Fetal akinesia sequence 0.683160502106017 1.662383522062182 0.0964359006850026 1.0 0.5717990599985453 6 P04062 1 +Enlarged ovaries 0.7908503052025027 1.6602639390780485 0.0968613668176749 1.0 0.5717990599985453 4 Q15437,P21912 2 +Cerebral dysmyelination 0.6712344833411115 1.659962106934675 0.0969220758248625 1.0 0.5717990599985453 7 P07602 1 +Conjunctival hamartoma 0.9279946164199208 1.6598384518738465 0.0969469559700031 1.0 0.5717990599985453 2 Q15437 1 +Follicular thyroid carcinoma 0.9279946164199208 1.6598384518738465 0.0969469559700031 1.0 0.5717990599985453 2 Q15437 1 +Bone cyst 0.9279946164199208 1.6598384518738465 0.0969469559700031 1.0 0.5717990599985453 2 Q15437 1 +Hyperextensible skin 0.5405039896976666 1.6558223509210583 0.0977578000678436 1.0 0.5733486088247625 14 Q9NWM8,Q9UHX1,P04062 3 +Abnormal macrophage morphology 0.7272800624995479 1.6545976294181484 0.0980061447063529 1.0 0.5733486088247625 5 Q13510,O15118 2 +Foam cells 0.7272800624995479 1.6545976294181484 0.0980061447063529 1.0 0.5733486088247625 5 Q13510,O15118 2 +Talipes equinovarus 0.3533529517247026 1.652448141082983 0.0984432285874776 1.0 0.5742755560219046 64 Q9HC21,O95202,Q9NR77,Q8NCH0,Q96AY3,Q9NWM8,Q6ZXV5,Q96A33,Q9BV10,P21964,Q8TAA9,Q9Y619,Q15392 13 +Abnormal morphology of the conjunctival vasculature 0.669638813763592 1.6520293768260426 0.0985285623624012 1.0 0.5742755560219046 7 P10619,Q9NW15 2 +Hyperlipidemia 0.4433041826367747 1.651190289827146 0.0986997252345542 1.0 0.5742755560219046 27 Q9UJS0,P23786,O95470,O75844,P06280,P22830,P28070 7 +Mitochondrial respiratory chain defects 0.6801733639075096 1.6478642105478511 0.0993805390443849 1.0 0.5742755560219046 6 P03886,P00846,Q4J6C6 3 +Leg muscle stiffness 0.7878068698913703 1.647070082958561 0.0995436415436006 1.0 0.5742755560219046 4 P00846 1 +Progressive spastic paraplegia 0.44653198071933 1.6470465546991029 0.0995484771682964 1.0 0.5742755560219046 26 O00400,P00846,Q9P0J0,O75298,Q96CU9 5 +Abnormality of the tarsal bones 0.4532470051045396 1.6460369753411113 0.0997561466683396 1.0 0.5746766311886029 24 Q96DX4,P16435,O75844,Q15058,Q9UHX1,Q14739 6 +Urticaria 0.6003202875500566 1.6402443022571616 0.1009543812626876 1.0 0.5791607457368096 10 P51648,P21912 2 +Abnormality of the distal phalanges of the toes 0.7238127315594468 1.638569980284726 0.1013028486085796 1.0 0.5791657809338997 5 O75431,Q7LGA3,O75844,Q71SY5 4 +Sclerocornea 0.6547494072336879 1.6349494573724943 0.1020596433891936 1.0 0.5826829693410609 8 P53701,O75569,O95202,Q6NUK1 4 +Corpus callosum atrophy 0.5372162613491861 1.6343974912886925 0.1021754146768556 1.0 0.5826829693410609 14 Q9H9P8,O75503,O60313,Q9Y5Y5,P51572 5 +Bruising susceptibility 0.4446648566426155 1.6308759982221357 0.1029164871930061 1.0 0.5849272013285636 26 P04062,Q8NCH0,Q14108,Q9NWM8,P35670,P49327,P38435,Q13126,Q86YV9 9 +Abnormal pleura morphology 0.5020311314010664 1.63068649147615 0.1029564883963924 1.0 0.5849272013285636 17 Q9NZ08,P01889,P14174,Q8NCH0,Q6NUK1,Q13043,P49327,Q14739 8 +Abnormal lung lobation 0.5698550534003402 1.6286681157565366 0.1033832959592566 1.0 0.5865554460125172 11 P21964,Q9UHX1,Q14739 3 +Basal ganglia cysts 0.664255218725338 1.6252245589527463 0.1041147193160523 1.0 0.5870877323326088 7 P36776,P00846,P23786 3 +Duplication involving bones of the feet 0.4879636682700367 1.6196819036242291 0.1053006254828592 1.0 0.589777365960286 18 O95202,O43924,Q10713,Q9UBM7,P21964,Q14739 6 +Constriction of peripheral visual field 0.4587392942922886 1.6190548798970748 0.1054354556630512 1.0 0.589777365960286 21 Q9Y5Y5,P00846,O60313,Q9H061,O75381 5 +Cogwheel rigidity 0.6737328630263977 1.6164984738757078 0.1059865830930135 1.0 0.589777365960286 6 P00846 1 +Retinal vascular tortuosity 0.5572338009011073 1.6157818053209727 0.1061414967133469 1.0 0.589777365960286 12 P21964,P03886,P00846 3 +Elevated serum acid phosphatase 0.7805963956886677 1.6157659127261494 0.1061449340582125 1.0 0.589777365960286 4 Q9NZJ7,P07602 2 +Abnormally lax or hyperextensible skin 0.4145455619132671 1.6157496172683172 0.1061484586283365 1.0 0.589777365960286 39 P04062,Q8NCH0,Q9Y487,Q9NWM8,Q9Y4P3,Q15904,Q6NUK1,Q9UHX1,P38435,Q9BV10,O96000 11 +Lower limb hyperreflexia 0.4743966230300113 1.615720688870553 0.106154715825449 1.0 0.589777365960286 19 Q14739,O00400,P13073,P21912 4 +Lymphopenia 0.4581271476737741 1.614106239262533 0.1065043842864785 1.0 0.5900279426305408 21 Q6PGP7,O95470,Q13043,Q13432,P49327,Q9BV10,P28070 7 +Cytochrome c oxidase negative muscle fibers 0.6731607339924206 1.613708188455074 0.1065907369858176 1.0 0.5900279426305408 6 Q9Y2R0 1 +Supranuclear gaze palsy 0.4579473908367206 1.6126526544904487 0.106819992056877 1.0 0.5905749988199505 21 O15118,P04062,Q9NZJ7,P07602,Q99720 5 +Hypoglycemic seizures 0.6614673488853344 1.6113194112161622 0.1071101220531518 1.0 0.5914568690935018 7 Q16836,P40939,P53985,Q13423 4 +Dysostosis multiplex 0.6610496944685387 1.6092348458760355 0.1075649996491425 1.0 0.5927480309692164 7 P16278,P10619,P54802,P04066 4 +Depletion of mitochondrial dna in muscle tissue 0.7790506296727491 1.60904688961514 0.1076060890731316 1.0 0.5927480309692164 4 Q9UBX3 1 +Nephrotic syndrome 0.4518516196956985 1.6084499598358604 0.1077366672896786 1.0 0.5927480309692164 23 Q8N1F7,Q9BW27,O95470,Q92621,Q8NCH0,Q14108,P51809,P57740,P06280,Q07021,Q9BT22 11 +Thoracic kyphosis 0.5326789186411335 1.604760668858587 0.1085464846956436 1.0 0.5950344826899207 14 Q9UHX1,P04062 2 +Submucous cleft of soft and hard palate 0.4726127143075603 1.6019991052871796 0.1091558073424019 1.0 0.5974455237506907 19 O43505,O75844,Q15392,Q9Y619 4 +Intracellular accumulation of autofluorescent lipopigment storage material 0.913189771197848 1.5969217677808485 0.1102831469060694 1.0 0.5991654975323172 2 O14773 1 +Hypoparathyroidism 0.5643775522284626 1.595990173387607 0.1104909872878721 1.0 0.5991654975323172 11 P35670,P00403,P21964,P03886 4 +Generalized muscle weakness 0.4248270808574386 1.593560239255658 0.111034565976557 1.0 0.600287894476094 30 O95831,P35637,Q15165,P40939,Q5JTZ9,Q92804,P10253,P12235,P21912,P53007 10 +Airway obstruction 0.5425734594291951 1.5932876155855349 0.1110956836508318 1.0 0.600287894476094 13 P21964,P06280,P09601,O75844 4 +Poor motor coordination 0.5533613664345847 1.5919811860006865 0.1113889319761682 1.0 0.6011550464697138 12 Q6PI48,O75503,Q96RL7,O95140,P35670,Q10713 6 +Increased urine alpha ketoglutarate concentration 0.7112558120048266 1.5803664276504656 0.1140229753145096 1.0 0.611001221566982 5 P09622,P21912 2 +Abnormal middle phalanx morphology of the hand 0.6656592508447655 1.5770646431566244 0.1147806516613385 1.0 0.6127302974663719 6 P02545,Q03164,P48651,Q9UHX1 4 +Myoclonic spasms 0.7101274948204112 1.5751246324061272 0.115227679342843 1.0 0.6131527160128148 5 Q10713,P00846 2 +Abnormal saccadic eye movements 0.4414962643372447 1.5739323305510229 0.1155030945533008 1.0 0.6131527160128148 25 P34897,Q6PI48,P22307,O14773,Q5THJ4,P04062,Q96RL7,Q9NW15,Q8IV08,P51798,Q10713,O43819 12 +Steppage gait 0.4686433018441125 1.5714072318549976 0.116088087240648 1.0 0.6147916479832213 19 O15269,Q8TB36,P07196,Q13501,P04792,Q9NR77,O95140,P02545,P05023,O43819,Q96BR5,Q15120,P31483 13 +Abnormal urine alpha ketoglutarate concentration 0.6532590807475662 1.5702843241664606 0.1163489794277909 1.0 0.6149512656844751 7 P09622,P21912 2 +Heterogeneous 0.408324359026644 1.567423266471364 0.1170157891219638 1.0 0.6149512656844751 40 P00846,Q9NR77,Q9BQE5,O75844,P12235,Q9Y619,P03886 7 +Flattened femoral head 0.9044414535666244 1.5597041879986633 0.1188298020122402 1.0 0.6198863404509491 2 Q96DX4 1 +Limb muscle weakness 0.357588077296033 1.55855724396493 0.119101209341756 1.0 0.6205259430966058 77 O15269,O00400,P35670,Q13126,P05023,P00846,Q99720,Q14739,Q9BQT8,P40939,Q13510,O43819,O75298,P50402,Q9NR77,Q16637,Q15067,P12235,Q8IY17 19 +Anorexia 0.4485754194521331 1.5578430352731898 0.1192704615645887 1.0 0.6205259430966058 22 Q9NZ08,P35610,P04062,Q14108,P06280,Q13423 6 +Angiokeratoma 0.7670033670033761 1.5565875808672915 0.119568434256831 1.0 0.6208782916455631 4 P06280,P16278,P17050 3 +Ventricular arrhythmia 0.4132603528522431 1.5556873973086147 0.1197824448360695 1.0 0.6212025287990335 35 P42892,P00846,P23786,P00403,P10253,P12235,P21912,P03886 8 +Mixed demyelinating and axonal polyneuropathy 0.7666786423559716 1.5551713805014653 0.1199052584298487 1.0 0.6212025287990335 4 P00403,P03886 2 +Bilateral sensorineural hearing impairment 0.4416092185835447 1.5478083110428322 0.1216684549158373 1.0 0.6250422822783042 24 O43681,Q9NZJ7,P35637,P07602,Q15067,P00403,P03886 7 +Congenital hepatic fibrosis 0.7649871450486527 1.5477925720309755 0.1216722454540053 1.0 0.6250422822783042 4 Q10713 1 +Abducens palsy 0.7649316480295623 1.547550427109705 0.1217305745773034 1.0 0.6250422822783042 4 P07602 1 +Abnormality of coagulation 0.3772176908328998 1.54746678730719 0.1217507272459064 1.0 0.6250422822783042 54 Q9UJS0,P09622,Q96AA3,Q9H3H5,Q16836,Q13586,O75352,P38435,O75381,Q00059,P50542,Q9Y487,P40939,Q9BV10,Q9Y5Y5,Q9Y619,Q4KMQ2,Q5XKP0,Q13043,O75648,P28288,P40855,P51571 23 +Brushfield spots 0.7646464646464747 1.546306062898957 0.1220306684227803 1.0 0.6253072061446754 4 O75381,P40855,Q9Y5Y5 3 +Paraplegia 0.3895024927096678 1.5455088404413524 0.1222232322209992 1.0 0.6253410118606608 49 Q15041,O00400,P00846,P04062,O60313,Q9P0J0,Q8IY17,O75298,Q9Y619,Q96CU9 10 +Esophageal varix 0.7035571374774758 1.5445637351735546 0.1224518236939404 1.0 0.6254478105343484 5 Q9NSD9,P04062 2 +Acne 0.5555521639097694 1.5431407812547644 0.1227966218120661 1.0 0.6254478105343484 11 P21964,Q9NZ08,Q92542,P49327 4 +Clonic seizure 0.6472665680349484 1.540239635938193 0.1235019517252451 1.0 0.6276283248169584 7 P07602 1 +Generalized clonic seizure 0.6577942362278117 1.5385313881553813 0.1239187400057593 1.0 0.6284279697674009 6 P07602 1 +Urinary glycosaminoglycan excretion 0.7022458673919285 1.5384571556308535 0.1239368765464419 1.0 0.6284279697674009 5 P54802,P16278,P04066 3 +Molar tooth sign on mri 0.6575817797278125 1.537488923296454 0.1241736254827068 1.0 0.6289241344359022 6 O43924 1 +Decreased light and dark adapted electroretinogram amplitude 0.9083744895007164 1.534766451749168 0.1248412062181119 1.0 0.628944103329517 3 P50897 1 +Arthralgia 0.4142096247319793 1.5342923116843772 0.1249577563179105 1.0 0.628944103329517 31 Q13510,Q9NZ08,P14174,Q15800,Q9Y4P3,P35670,P06280,P49327,P28070 9 +Generalized edema 0.7618445800611291 1.5340759278537124 0.1250109746017149 1.0 0.628944103329517 4 Q9H3H5 1 +Abnormal pharynx morphology 0.4118857320894091 1.5332557772410258 0.1252128460719694 1.0 0.6292605627235047 34 Q96DX4,P54802,Q9H0U3,Q13432,Q03518,Q9BV10,Q13510,P16278 8 +Abnormal labia minora morphology 0.656318368599667 1.5312880409100604 0.1256982198903518 1.0 0.6305501493349525 6 P16435,P31939,Q9Y619 3 +Blurred vision 0.7003431507107449 1.529591921520206 0.1261177703269842 1.0 0.6305501493349525 5 P00846 1 +Infantile spasms 0.4173064388163905 1.5236182609055773 0.1276040988211029 1.0 0.6305501493349525 30 Q13510,Q9UBX3,P00846 3 +Decreased ldl cholesterol concentration 0.905574647844754 1.5236167235674805 0.1276044830779521 1.0 0.6305501493349525 3 Q15800 1 +Abnormal mitral valve physiology 0.4078643055099875 1.5235612037814967 0.1276183608224794 1.0 0.6305501493349525 37 Q9NZ08,Q96DX4,P04062,Q9Y4P3,O75844,P40939,P49327,P06280,P51812,P53701,O43819 11 +Microdontia 0.4409127326192412 1.517147851161214 0.1292293592276581 1.0 0.6305501493349525 23 Q9UM00,Q9Y487,Q9Y4P3,Q15436,Q9Y619,Q6NUK1,Q96A33,Q7LGA3 8 +Hallucinations 0.3982605242771082 1.5122319018537629 0.1304748779897706 1.0 0.6336670975231874 43 O43681,O75503,Q9UJS0,P04062,Q9NZJ7,O60313,Q9BQE5,P07602,O76024,P51649,P50897,P21964,O96008 13 +Abnormal arterial physiology 0.4343061545810044 1.512062851014068 0.1305178742569068 1.0 0.6336670975231874 25 Q9NZ08,P01889,Q9NWM8,Q9Y4P3,O75844,P06280,P49327,Q14739 8 +Mitral stenosis 0.9026539488748158 1.5119820711089698 0.1305384236400195 1.0 0.6336670975231874 3 P04062 1 +Aortic valve calcification 0.9026539488748158 1.5119820711089698 0.1305384236400195 1.0 0.6336670975231874 3 P04062 1 +Ascending tubular aorta aneurysm 0.6962187104791503 1.5103580193389616 0.1309520945415763 1.0 0.6336670975231874 5 Q96L58,P01889,O75844 3 +Inverted nipples 0.6304094024897395 1.510228994607717 0.1309850026640402 1.0 0.6336670975231874 8 Q96AA3,Q9H3H5,Q9BV10,Q15067 4 +Increased blood pressure 0.3443709141011202 1.5086591261845217 0.1313859159585857 1.0 0.6345792966529203 66 P42892,P35610,Q9UMS0,P04062,P16435,Q9Y4P3,O75844,Q9NSD9,P06280,Q13043,P00403,Q10713,P21912,P21964,Q8TAA9,Q96J02,P03886 17 +Abnormality of blood circulation 0.342585390315027 1.5082742201106578 0.1314843584115679 1.0 0.6345792966529203 64 Q9NZ08,Q9UJS0,P04062,P23786,Q9Y487,O75844,Q9H3H5,O76024,Q9UHX1,P38435,Q14739,P21912,P21964 13 +Impaired antigen specific response 0.6513366901918192 1.5068101453963254 0.1318593283176232 1.0 0.6345792966529203 6 P49327,Q9BV10 2 +Abnormality of lipoprotein cholesterol concentration 0.5288992748726861 1.506244378200216 0.1320044509533089 1.0 0.6345792966529203 13 Q8N511,Q15800,Q9UJS0,P37268 4 +Abnormal basal ganglia mri signal intensity 0.4267845827384849 1.5051174898608644 0.1322938731783485 1.0 0.6348050058305399 27 P03886,Q9P0J0,P00846,Q96CU9 4 +Chronic pulmonary obstruction 0.6949571223812632 1.5044701530339084 0.1324603528490393 1.0 0.6348050058305399 5 P21964,P09601 2 +Hemiparesis 0.5173969010890049 1.504375527150429 0.1324847019677253 1.0 0.6348050058305399 14 Q9NZ08,O60313,P49327,P00403,P03886 5 +Abnormal elasticity of skin 0.3677904427610509 1.5015302924569622 0.1332184577003614 1.0 0.6354674508626409 56 P04062,Q8NCH0,Q9Y487,Q9NWM8,Q15904,O75844,Q6NUK1,Q9UHX1,P38435,Q13126,Q9BV10,O96000 12 +Hypocalcemia 0.5386996634402085 1.5014224323294814 0.1332463354338229 1.0 0.6354674508626409 12 Q9NSD9,P40939,P51798,Q9BV10,P21964 5 +Abnormal aortic valve physiology 0.4093316359338107 1.500640377035508 0.1334486020050223 1.0 0.6354674508626409 33 Q9NZ08,Q6PGP7,P04062,O75844,Q6ZXV5,P49327,Q9UHX1,P16278 8 +Abnormal speech prosody 0.6284498348979197 1.500132579433593 0.1335800632134987 1.0 0.6354674508626409 8 P00846,P04062 2 +Abnormal heart valve morphology 0.342799264295553 1.499308026363606 0.1337937411037764 1.0 0.6354674508626409 65 Q6PGP7,P37268,P04062,O95202,Q8NCH0,Q9Y4P3,P55795,O75844,Q6NUK1,Q6ZXV5,P06280,P51798,Q9UHX1,P53701,P21964,P16278 16 +Urinary urgency 0.6276419374423112 1.495967705298231 0.1346620711199084 1.0 0.6354674508626409 8 P04062 1 +Hydrocele testis 0.7526669383677164 1.49396171084243 0.1351856272890388 1.0 0.6354674508626409 4 Q9UBX3 1 +Neonatal death 0.5269107329580696 1.4935337451054305 0.1352975278533137 1.0 0.6354674508626409 13 Q14739,O96000,Q9NVI7,P04062 4 +Abnormal corneal epithelium morphology 0.4829902754029291 1.4935091095290869 0.1353039715159545 1.0 0.6354674508626409 17 Q14739,Q9NZ08,P51648,O75844 4 +Abnormal tongue morphology 0.3422891012504728 1.4924343827494069 0.1355853070811166 1.0 0.6354674508626409 65 Q9NQT5,P48651,Q96RL7,Q9Y4P3,P20700,Q96A33,Q10713,O94905,Q7LGA3,P16278,Q15437,P01889,Q71SY5,O43924,P04066,Q9UBM7,P02545,P07196,P61978,O75844,Q9NRZ9,P10253,P21912,Q9Y5Y5,Q6NUK1,O75648,O75431 27 +Arteriosclerosis 0.5265069723733853 1.4909513547500115 0.1359742669503951 1.0 0.6354674508626409 13 Q13510,P16278,O75844,O15118 4 +Cardiorespiratory arrest 0.7519783169464627 1.4909486511672227 0.1359749768161133 1.0 0.6354674508626409 4 Q96L58,P13473 2 +Macrovesicular hepatic steatosis 0.6371689411803487 1.489454706594334 0.13636767192413 1.0 0.6354674508626409 7 P23786,Q5XKP0,O75648,O75431,P39210 5 +Renal tubular dysfunction 0.4019726461052009 1.4889681963253527 0.1364957437562646 1.0 0.6354674508626409 39 Q9NWS8,Q8IUX1,Q9Y6M9,O43676,O43819,Q86Y39,P00403,O96000,P40855,P03886,Q96CU9 11 +Motor seizure 0.3710358387571918 1.4872072534859166 0.1369600809108273 1.0 0.6354674508626409 100 O75503,P13073,O43292,Q9H3H5,Q9NZ01,Q8WWV3,Q9UBX3,P16278,Q01105,P00846,P04062,Q9NZJ7,Q71SY5,P07602,Q9Y320,P21912,Q13510,Q9Y619,P03886,Q5XKP0,Q96N66 21 +Intestinal malrotation 0.434347816335565 1.486094098836367 0.1372542329822577 1.0 0.6354674508626409 24 O95202,Q8NCH0,Q9NSD9,Q9BV10,Q14739,P21964,Q15392 7 +Episodic tachypnea 0.5992599455193413 1.4837384795455146 0.1378783136738108 1.0 0.637704805224735 9 O43924,P22695 2 +Thoracic scoliosis 0.5252911956422454 1.4831722421050315 0.138028654103822 1.0 0.6377487201858226 13 O75844,O75477,Q9UHX1 3 +Abnormal ldl cholesterol concentration 0.5355946876770505 1.4821573281569216 0.1382984377625773 1.0 0.6383438595198269 12 Q8N511,Q15800,Q9UJS0,P37268 4 +Drowsiness 0.6899763554430354 1.4812044559345172 0.1385520991798694 1.0 0.6388634471348766 5 P35270 1 +Abnormal caudate nucleus morphology 0.5442843273059714 1.475323991969868 0.1401254591824126 1.0 0.6448049585141913 11 P00846 1 +Atrophy degeneration involving the corticospinal tracts 0.502451821242278 1.4738192219516353 0.1405302714406922 1.0 0.6453497289800179 15 O00400,Q9Y4P3,P00846,O75298 4 +Redundant skin 0.4356885811881303 1.473295333670169 0.1406714183973669 1.0 0.6453497289800179 23 Q8NCH0,Q9Y487,Q9Y4P3,Q6NUK1,Q9BV10,P38435,O96000 7 +Varicose veins 0.7474870125659479 1.471286674686303 0.1412136054456014 1.0 0.645588907471506 4 P04062 1 +Venous insufficiency 0.7474870125659479 1.471286674686303 0.1412136054456014 1.0 0.645588907471506 4 P04062 1 +Emg impaired neuromuscular transmission 0.6438188936806646 1.4697901107569915 0.1416186083422115 1.0 0.645588907471506 6 O60313,Q9H3H5 2 +Abnormal femoral neck head morphology 0.398716423324119 1.4694100863145922 0.1417215932037714 1.0 0.645588907471506 40 Q96L58,Q96DX4,Q96AY3,O95831,Q9Y487,Q96HY6,O75844,Q9Y619,Q96A33,P04066,Q14739,O75718,P51812,P38646,Q7LGA3,P16278,P50542 17 +Infectious encephalitis 0.6211919174969891 1.4626695665371614 0.1435578175487286 1.0 0.6507550250605555 8 Q9H9P8,Q9NZ08,P49327,Q14739 4 +Hydrocephalus 0.3435633957462168 1.4626094915377863 0.1435742645838107 1.0 0.6507550250605555 69 O95202,P04062,Q9H490,P23786,P16435,Q6NUK1,Q10713,P53701,Q9UBM7,Q8TAA9,P40855,P21964,Q15392,O43505 14 +Distal sensory impairment of all modalities 0.6408880878297933 1.4553325841981382 0.1455772100870951 1.0 0.6574426566457355 6 O15269 1 +Widened cerebral subarachnoid space 0.7438016120591459 1.4551399623836485 0.1456305178038146 1.0 0.6574426566457355 4 P03886,Q9BV10 2 +Irritability 0.3428183106317659 1.4525653735167985 0.1463444659261312 1.0 0.6579495799662334 69 Q9HC21,Q9NZ08,P00846,P37268,Q9NZJ7,P07602,Q15067,P50897,Q13510,P21912 10 +Spastic paraparetic gait 0.6836468144777443 1.4515935688559995 0.14661464800926 1.0 0.6579495799662334 5 Q15041,Q15043,O75787 3 +Abnormal circulating carbohydrate concentration 0.3993935257343886 1.4503811836217575 0.1469522512959773 1.0 0.6588116770972132 38 Q9UJS0,Q8IUX1,Q9BWD1,O43676,Q86Y39,Q70HW3,P21912,O96000,P22695,P03886,Q96CU9 11 +Multifocal cerebral white matter abnormalities 0.6828644642556869 1.4479302283621502 0.1476365646427369 1.0 0.659343413501054 5 Q9Y619 1 +B lymphocytopenia 0.6826907754132344 1.44711683640098 0.1478642033146533 1.0 0.6594731440255166 5 Q13432 1 +Anasarca 0.8771870794078112 1.4436670696640912 0.1488326487420748 1.0 0.6612456598066272 2 Q9H3H5 1 +Cirrhosis 0.39949675334911 1.4401067111990578 0.1498372106631926 1.0 0.6612456598066272 37 Q9UJS0,Q6PGP7,P04062,Q14108,Q15904,Q9NSD9,P35670,Q13043,P22830,Q10713,Q14739,Q00059 12 +Palmar telangiectasia 0.876177658142669 1.4393691019834889 0.1500459737844326 1.0 0.6612456598066272 2 Q14739 1 +Abnormal endocardium morphology 0.5074674509731302 1.4387066126058294 0.150233665013415 1.0 0.6612456598066272 14 Q9NZ08,P04062,Q9Y4P3,P06280,P49327 5 +Abnormal renal cortex morphology 0.379734795135039 1.4365085887890072 0.15085767415977 1.0 0.6612456598066272 49 Q9NZ08,P00846,O95470,Q14108,P06280,P49327,P00403,P21912,P03886 9 +Morphological abnormality of the corticospinal tract 0.4750003918311392 1.4354833991261062 0.1511493955949925 1.0 0.6612456598066272 17 O00400,P00846,Q9Y4P3,P35637,O75298 5 +Papilloma 0.5639048940630933 1.4332659064796107 0.1517818612632926 1.0 0.6614709025988345 10 P16615,Q15437,P21912 3 +Delayed menarche 0.6794921664249478 1.4321314115704582 0.1521062163287923 1.0 0.6622470649392034 5 O75844 1 +Leukoencephalopathy 0.3570679942136554 1.4293989346874818 0.1528896044380789 1.0 0.6644488378105153 88 O75503,Q86Y39,Q9UHX1,O96000,Q9H9P8,O43681,Q01105,Q9NZJ7,O43676,Q9Y6M9,O95831,P07602,P17900,Q96CU9,P03886,Q8IUX1,O95202,O60313,O15121,P51571 20 +Abnormal nasal mucosa morphology 0.737889522105929 1.4292150431877773 0.1529424352892563 1.0 0.6644488378105153 4 Q13432 1 +Abnormal delivery 0.4353936549842713 1.4288333049408737 0.1530521505822366 1.0 0.6644488378105153 21 O60313,Q9Y487,O75844,O75718,Q9Y619 5 +Head titubation 0.6243728039585419 1.42482964595824 0.1542064504651117 1.0 0.6683996357938013 7 Q96RL7,P35637,Q99720 3 +Abnormal urine protein level 0.3764048367206745 1.4237401542558203 0.1545217053589169 1.0 0.6683996357938013 50 P04062,O95470,Q14108,Q9Y4P3,P09601,P06280,P00403,P21912,P03886 9 +Acute hepatic failure 0.4950724788982124 1.423458293185106 0.1546033442347765 1.0 0.6683996357938013 15 Q16836,P01889,Q6NUQ1,P08574,P35670,P40939,O75648,Q13043,Q96J02 9 +Abnormal circulating fatty acid concentration 0.4495456872060227 1.4231238035973974 0.1547002690618162 1.0 0.6683996357938013 19 Q16836,Q9Y5Y5,O43772,P23786,P09622,O75880,P40939,O75648,O75381,P40855,P50542 11 +Wide anterior fontanel 0.4365599131026692 1.4203297167756377 0.1555117136512402 1.0 0.6696615797971188 20 Q9Y5Y5,Q9Y487,P16435,Q15436,Q6NUK1,O75381,O75718,P40855,Q32P28,P50542 10 +Gastric ulcer 0.8793924591396011 1.4192161046252076 0.1558360221895283 1.0 0.6696615797971188 3 P04062 1 +Migraine 0.429228742332296 1.4188584954294532 0.1559402747041529 1.0 0.6696615797971188 23 Q13586,Q9NZ08,P01889,O60313,P49327,P00403,P12235,P03886,Q9NQZ5 9 +Hypointensity of cerebral white matter on mri 0.6334977024914874 1.418816248429834 0.1559525943133894 1.0 0.6696615797971188 6 P07602 1 +Diffuse white matter abnormalities 0.5871816021631088 1.418107761758737 0.1561593055205521 1.0 0.6696615797971188 9 Q9H936,O43819,P16278 3 +Inflammatory abnormality of the eye 0.4016753611722439 1.414860974959388 0.1571092620410465 1.0 0.6711233382281688 31 Q9NZ08,P01889,P14174,Q15800,Q13043,P49327,Q14739,P28070,P51648,P04439 10 +Progressive cerebellar ataxia 0.3979102623033542 1.4141003050704797 0.1573324535994045 1.0 0.6714433081037734 36 Q8N183,Q6PI48,Q5THJ4,O14773,Q9Y487,Q9P0J0,P35637,Q9NW15,P41440,O76024,Q9Y619,Q8NI60,Q96CU9 13 +Telangiectasia of the skin 0.448176527235172 1.4124267399688393 0.1578243476225025 1.0 0.6723662670671569 19 Q8IZA0,Q8N6S5,P06280,Q13043,Q14739 5 +Patchy changes of bone mineral density 0.7339327078165332 1.4118497932084229 0.1579941934981128 1.0 0.6723662670671569 4 Q13126 1 +Ulnar claw 0.674974738969349 1.4109479356569492 0.1582599663187496 1.0 0.6728649084425335 5 Q8TB36,Q9NR77,P39210,P07196 4 +Zonular cataract 0.5235219523413163 1.4069798124760775 0.1594333750130885 1.0 0.6752535450677307 12 O76024,Q99797,Q9H6K4,Q8WWV3,P08670 5 +Basal ganglia gliosis 0.5850433584118516 1.4064571410926163 0.1595884227669215 1.0 0.6752535450677307 9 P00846 1 +Onion bulb formation 0.6309728957302113 1.4063221479703445 0.1596284863016812 1.0 0.6752535450677307 6 O95140,P02545,Q9NR77,P07196 4 +Abnormal lymphocyte morphology 0.4121134486177604 1.4049471447040502 0.1600369960306407 1.0 0.6759771623383779 28 Q6PGP7,O95470,Q13043,P49327,Q13432,Q9BV10,P28070,P16278 8 +Retinal dystrophy 0.3621800005316813 1.4006152927967808 0.1613291453526557 1.0 0.6797066861935219 55 Q9NQT5,Q9Y5Y5,P00846,Q15067,Q9H3H5,P40855,Q10713,P53701,P38435,O75381,Q6P4Q7,Q8IY17,P03886,O43505 14 +Parkinsonism 0.3996245627782959 1.400433905156474 0.1613834228904553 1.0 0.6797066861935219 32 O75787,P04062,Q96RL7,Q9NZJ7,Q15043,P35637,P07602,O43464,Q99720,P17480,P05067,O96008,O75569 13 +Distal peripheral sensory neuropathy 0.7302449947434302 1.3956560412135768 0.1628180977638822 1.0 0.6819984705595363 4 P00403,P03886 2 +Recurrent bronchitis 0.865410497981163 1.39353481325124 0.163458125203076 1.0 0.68200203217047 2 Q03518 1 +Decreased specific anti polysaccharide antibody level 0.8654104979811582 1.3935348132512186 0.1634581252030824 1.0 0.68200203217047 2 P49327 1 +B cell lymphoma 0.8654104979811582 1.3935348132512186 0.1634581252030824 1.0 0.68200203217047 2 P49327 1 +Abnormal form of the vertebral bodies 0.3468862988669571 1.3926346476492593 0.1637303001085877 1.0 0.6820338536262052 79 Q96L58,P54802,Q9Y4P3,P36776,Q10713,Q9UHX1,P16278,Q96DX4,O95831,P16435,Q96HY6,Q15436,P04066,Q14739,Q9UBM7,Q32P28,P15586,Q96AY3,Q6NUQ1,P51798,Q9BV10,Q8TAA9,P51812,Q9Y619,Q96J02,Q9UM00,O95202,Q6NUK1,P38646 29 +Pulmonary hypoplasia 0.4202391884834137 1.3901085424875066 0.1644959196561779 1.0 0.6833371781680493 25 O75844,Q6NUK1,Q9H3H5,Q5JTZ9,Q14739,Q8TAA9,O96000 7 +Abnormality of the wrist 0.4133470021380595 1.3849662873377389 0.1660627761143662 1.0 0.6870225391458422 27 Q96DX4,O95831,O75844,Q9BV10,Q9H6K4,Q13510,P16278 7 +Abnormal diaphysis morphology 0.3400236068731441 1.382827749307557 0.1667176882314043 1.0 0.6870225391458422 62 Q96DX4,Q9NR77,Q96AY3,Q9Y487,P16435,Q9Y4P3,Q9HC07,Q9NX62,Q9Y619,P51798,Q13126,O75718,Q7LGA3,P16278,Q14739 15 +Abnormal femoral neck morphology 0.397044653000857 1.381509745106995 0.1671222835654902 1.0 0.6870225391458422 33 Q96L58,Q96DX4,Q96AY3,O95831,Q9Y487,Q96HY6,O75844,Q96A33,P04066,O75718,P51812,Q9Y619,P16278 13 +Contractures of the joints of the upper limbs 0.3397853350497565 1.3796801684696434 0.1676851415956888 1.0 0.6870225391458422 62 Q96L58,P48651,Q9UJX6,P57740,Q99567,Q7LGA3,Q8IZA0,Q71SY5,P16435,Q99720,O95155,Q15392,P50542,P42892,P37268,P07196,P23786,Q96AY3,O75844,Q9BTV4,Q9Y619,Q9Y3E5,P50402,Q9NR77,P35637 25 +Aspiration pneumonia 0.4269838596994495 1.3787226333933331 0.1679802883731334 1.0 0.6870225391458422 22 Q13510,P16278,P04062 3 +Abnormal sensory nerve conduction velocity 0.7262626262626425 1.3781589072516631 0.1681542313888664 1.0 0.6870225391458422 4 O15269,Q9Y3E5,Q9NR77 3 +Abnormal adipose tissue morphology 0.3653273394466239 1.3771451163802544 0.1684673863259256 1.0 0.6870225391458422 53 P50402,P42167,P28070,Q9Y487,O75844,Q9H3H5,P49327,Q9BV10,P21912,Q8TAA9,Q15437 11 +Respiratory arrest 0.6044885535512992 1.376072402984187 0.1687992185371727 1.0 0.6870225391458422 8 Q96L58,P53007,P13473,P23786 4 +Decreased activity of mitochondrial complex iii 0.6243261455525588 1.3733871048551802 0.1696320364301189 1.0 0.6870225391458422 6 P53597,Q9HA77,Q5JPH6,Q96RP9,P43897 5 +Abnormal pulmonary interstitial morphology 0.4047748618031044 1.3706643557321865 0.1704796111271795 1.0 0.6870225391458422 29 Q8IZA0,P04062,Q14108,P09601,Q9NSD9,Q13432,P49327,Q13510 8 +Anencephaly 0.4969539709685009 1.368824700482529 0.1710540778681624 1.0 0.6870225391458422 14 P21964,O43505 2 +Oculomotor apraxia 0.4115489203281944 1.3688046939309169 0.1710603332463907 1.0 0.6870225391458422 27 Q9NQT5,O14773,P04062,O43292,O43924,P35270,Q10713,P05067,O96008 9 +Ureteral duplication 0.6129657157305592 1.366989298153003 0.1716286599600569 1.0 0.6870225391458422 7 O75844,P23786 2 +Upper airway obstruction 0.7235690235690329 1.3663190352399943 0.1718388489127333 1.0 0.6870225391458422 4 P16435,Q96HY6,O75844 3 +Peroneal muscle atrophy 0.7235690235690269 1.3663190352399683 0.1718388489127416 1.0 0.6870225391458422 4 Q96RL7,Q12768,Q9NR77 3 +Fasting hyperinsulinemia 0.723569023569026 1.3663190352399657 0.1718388489127424 1.0 0.6870225391458422 4 Q16836,P40939,P00367 3 +Hypermetric saccades 0.7234741702807899 1.365902031714351 0.1719697149698458 1.0 0.6870225391458422 4 O14773,Q9NW15 2 +Abnormal circulating acetylcarnitine concentration 0.6225644710152263 1.3646478141645693 0.1723637690216468 1.0 0.6870225391458422 6 Q16836,P40939,P23786 3 +Abnormality of the larynx 0.3826620436296755 1.3645201382976893 0.1724039204773397 1.0 0.6870225391458422 44 Q9UBM7,Q9NZJ7,P16435,Q15165,P07602,Q92804,Q9UHX1,Q14739,Q13510,P21964 10 +Corneal dystrophy 0.7230196392899333 1.3639037121423454 0.1725978723613039 1.0 0.6870225391458422 4 P06280,P12235 2 +Hypopigmentation of the skin 0.3856461881694573 1.363229615237494 0.1728101564708348 1.0 0.6870225391458422 42 Q8IZA0,Q6PGP7,Q9NZJ7,P07602,P49327,P53701,P21912,P21964,Q86YV9,Q15437 10 +Abnormality of the pharynx 0.3855935098925389 1.3626758159984984 0.1729847029115949 1.0 0.6870225391458422 42 Q96DX4,P54802,Q9H0U3,Q13432,Q03518,Q9BV10,P21964,Q13510,P16278 9 +Expressive language delay 0.5515416202483684 1.3622430838984574 0.1731211831195684 1.0 0.6870225391458422 10 Q96DX4,Q9UHX1 2 +Hypoplastic vertebral bodies 0.6217142812049042 1.360428750675648 0.1736942854760614 1.0 0.6880907477126914 6 Q14739,Q8TAA9 2 +Unilateral renal agenesis 0.4287285765445962 1.3566820279537826 0.1748822653576649 1.0 0.6888893854057139 20 P16435,Q86XL3,Q15058,Q9UHX1,Q7LGA3 5 +Narrow pelvis bone 0.8566621803499386 1.3563182427399458 0.1749979335828011 1.0 0.6888893854057139 2 Q96DX4 1 +Vaginal atresia 0.8566621803499324 1.3563182427399194 0.1749979335828095 1.0 0.6888893854057139 2 Q15058 1 +Aplasia hypoplasia of the femur 0.4749254030090693 1.356013436186188 0.1750948930554983 1.0 0.6888893854057139 16 Q96L58,Q96DX4,O95831,Q96HY6,Q9UHX1,Q9BV10,O00116,P50542 8 +Generalized onset seizure 0.3634829465021172 1.355541915055007 0.1752449636810442 1.0 0.6888893854057139 103 O75503,O43292,Q9H3H5,Q9NZ01,P05023,P16278,Q01105,P00846,P04062,Q9NZJ7,Q71SY5,P07602,Q6PJG6,Q9Y320,P51649,Q9NVI7,P21912,Q13510,Q9Y619,P03886,Q14108,Q9NW15,P00374,Q96N66 24 +Vascular neoplasm 0.3943748385850483 1.3554785316125508 0.1752651439901462 1.0 0.6888893854057139 33 P10619,Q8N6S5,O95202,P16435,Q9UHX1,P21912,Q7LGA3,Q15437 8 +Abnormalities of placenta or umbilical cord 0.4947977316904025 1.3544508019260404 0.1755925992781644 1.0 0.6895778747021062 14 P16278,O75844,Q6PGP7 3 +Secondary microcephaly 0.3387393074702043 1.3510050397160898 0.1766938183079525 1.0 0.6901403075372317 73 Q9HC21,O75208,Q9Y487,O15121,Q86Y39,P55795,Q9HC07,Q15043,Q5XKP0,Q9UHX1,P50897,Q9BV10,P00374,Q9BT22,Q96CU9 15 +Abnormal circulating ceruloplasmin concentration 0.862123771834849 1.3502857809009765 0.1769243315733391 1.0 0.6901403075372317 3 Q8N511 1 +Abnormal placental size 0.7197115541217148 1.3493567925069807 0.1772223919790294 1.0 0.6901403075372317 4 O75844 1 +Foot dorsiflexor weakness 0.4023748811256111 1.3483597275839068 0.1775427103033102 1.0 0.6901403075372317 29 O15269,Q9BQT8,Q9NR77,Q14739,O43819 5 +Insidious onset 0.6615297267575426 1.3477788935881831 0.177729508378226 1.0 0.6901403075372317 5 P04062,Q9NR77 2 +Alkalosis 0.7192433230580001 1.3472973782546285 0.1778844761571618 1.0 0.6901403075372317 4 Q9Y619 1 +Abnormal brain choline level by mrs 0.8608139686636207 1.3450573534531434 0.1786067138389506 1.0 0.6901403075372317 3 P07602 1 +Reduced brain n acetyl aspartate level by mrs 0.8608139686636207 1.3450573534531434 0.1786067138389506 1.0 0.6901403075372317 3 P07602 1 +Abnormal brain n acetyl aspartate level by mrs 0.8608139686636207 1.3450573534531434 0.1786067138389506 1.0 0.6901403075372317 3 P07602 1 +Decreased proportion of cd4 positive helper t cells 0.7177244369452133 1.3406162030633235 0.1800450937818785 1.0 0.6901403075372317 4 P49327,Q13432 2 +T lymphocytopenia 0.7177244369452133 1.3406162030633235 0.1800450937818785 1.0 0.6901403075372317 4 P49327,Q13432 2 +Progressive peripheral neuropathy 0.8596432177717838 1.34038409504863 0.1801205038781028 1.0 0.6901403075372317 3 Q9NZJ7,P07602 2 +Vegetative state 0.8596432177717838 1.34038409504863 0.1801205038781028 1.0 0.6901403075372317 3 Q9NZJ7,P07602 2 +Slowly progressive 0.3571355665345252 1.3397828099418314 0.1803159658882254 1.0 0.6901403075372317 55 O14979,Q8N2K0,O00584,Q9H3H5,P41440,P05023,Q13586,Q6PI48,O75787,O95831,Q8IV08,Q99720,O14773,Q9P0J0,Q9BTV4,P50402,Q16637,Q9NR77,P12235 19 +Facial capillary hemangioma 0.8522880215343195 1.3377218185542088 0.1809871357890127 1.0 0.6901403075372317 2 P16435 1 +Macrogyria 0.6171186678033473 1.337607192612888 0.1810245185486456 1.0 0.6901403075372317 6 Q15392 1 +Tetraplegia tetraparesis 0.3765470844451365 1.3355470444224835 0.1816973687933318 1.0 0.6901403075372317 46 Q9H9P8,O43681,P00846,Q9NZJ7,O95831,P07602,P51572,P17900,P21912,Q9UBX3,Q13423 11 +Fatigue 0.3391917635361154 1.334149592846164 0.1821548355633793 1.0 0.6901403075372317 75 Q53H12,Q92804,Q70HW3,Q13423,P01889,P04062,Q9NZJ7,Q15165,P07602,Q14739,P06280,P49327,P21912,Q9NZ08,O60313,P35637,Q13043,P12235,Q4J6C6 19 +Scanning speech 0.8576040616277341 1.3322447480101167 0.1827797765667158 1.0 0.6901403075372317 3 O14773 1 +Kinetic tremor 0.391952851820322 1.3318210078116668 0.1829190129916651 1.0 0.6901403075372317 33 O43681,Q9NZJ7,Q14108,Q9NW15,P07602,Q8N2K0,P54136,O75027,Q8IY17 9 +Low set posteriorly rotated ears 0.3302181344526527 1.3287498582608237 0.1839305097989414 1.0 0.6911513264478065 65 Q9Y4P3,Q10713,P04062,P16435,O43924,Q9UBM7,O95155,O75381,Q15392,P37268,Q8NCH0,Q9Y5Y5,Q96J02,Q9UM00,O95202,Q6NUK1,P40855,Q8IY17,Q4J6C6 19 +Laryngomalacia 0.5199478735474091 1.3276694970424583 0.1842873146284602 1.0 0.6919178778090117 11 Q9NZJ7,P21964,P07602 3 +Progressive pes cavus 0.6567048976537978 1.3250713201075688 0.1851474974326938 1.0 0.6939965797808261 5 O00400 1 +Ectopia lentis 0.6561685965848196 1.3225461586301597 0.1859863494819715 1.0 0.6951806633392559 5 Q03518 1 +Abnormality of the tonsils 0.6560870417319932 1.3221621407515194 0.1861141649431119 1.0 0.6951806633392559 5 P21964 1 +Psychotic mentation 0.6559146459729933 1.321350363557021 0.1863845683069471 1.0 0.6951806633392559 5 P03886 1 +Slurred speech 0.5088980791575765 1.3153852629163016 0.1883804558266379 1.0 0.6985593505504717 12 Q6PI48,Q96RL7,Q9Y487,Q9NW15,P16278 5 +Abnormal periventricular white matter morphology 0.3878426091591934 1.3135938331907369 0.18898292510157 1.0 0.6985593505504717 36 O75503,O43681,O95202,Q9NZJ7,O60313,O15121,P07602,P17900,Q53FT3,Q5JTZ9,O75648,Q9UHX1,P11177,P51571 14 +Abnormal auditory evoked potentials 0.5918357623045734 1.3101590735140278 0.1901420276580316 1.0 0.6985593505504717 8 Q9NZJ7,P07602 2 +Neurofibrillary tangles 0.7105275836706421 1.308946612792503 0.190552435579014 1.0 0.6985593505504717 4 O96008,O15118 2 +Abnormality of the musculature of the lower limbs 0.4079954466741824 1.3087460819913348 0.190620376405306 1.0 0.6985593505504717 26 P50402,Q6PI48,Q12768,P00846,P07196,Q96RL7,Q9NR77,O14979,Q9NW15,Q9BTV4,P02545,P53007 12 +Inability to walk 0.344697360226401 1.30715210667286 0.1911610575269537 1.0 0.6985593505504717 84 O15269,Q15041,Q96N66,O75503,Q71SY5,P00846,Q9NR77,O43292,Q15043,Q9H3H5,P12235,P21912,Q13510,O14949,Q9NVI7,Q96CU9 16 +Tube feeding 0.3309400563157484 1.3052458718033295 0.1918091388309142 1.0 0.6985593505504717 63 Q01105,P37268,Q9H490,Q9NZJ7,O15121,P07602,Q9NZ01,Q9UHX1,Q9BV10 9 +Abnormal blood inorganic cation concentration 0.3890146635678056 1.30306835364482 0.1925514265624321 1.0 0.6985593505504717 33 Q15043,Q9Y4P3,Q9NSD9,P40939,P51798,Q9BV10,P21912,P21964,P05023 9 +Retinopathy 0.4127511838268681 1.3007845028200449 0.1933322279729776 1.0 0.6985593505504717 24 Q9NZ08,P00846,O95202,O43819,P40939,P49327,P51648 7 +Unusual infection by anatomical site 0.5065401066679731 1.3005673277494512 0.193406596552591 1.0 0.6985593505504717 12 Q9H9P8,Q9NZ08,P01889,P49327,Q14739,Q8TAA9 6 +Opsoclonus 0.8432032301480579 1.2991319176054734 0.1938986611914936 1.0 0.6985593505504717 2 P04062 1 +Hypoproteinemia 0.8492073889367829 1.2987356490636204 0.1940346654615239 1.0 0.6985593505504717 3 Q9H3H5 1 +Abnormality of the parathyroid gland 0.4560207669808523 1.2966693843867665 0.1947449677304562 1.0 0.6985593505504717 17 P35670,P00403,P21964,P03886 4 +Meningioma 0.6085012937390373 1.294746724074445 0.1954076158810147 1.0 0.6985593505504717 6 Q15437 1 +Abnormality of the knee 0.3379575615940713 1.2945745782853162 0.1954670267551783 1.0 0.6985593505504717 77 Q9Y4P3,Q6ZXV5,Q9H3H5,Q7LGA3,P16278,Q96DX4,O95831,Q9NX62,Q86XL3,P37268,P23786,Q96AY3,P21912,Q13510,Q9Y619,Q15041,Q9NR77,P21964,O75477 19 +Lower limb amyotrophy 0.4552602574973449 1.2910812223950652 0.1966755145795746 1.0 0.701217897650641 17 O00400,O75298,Q9NR77 3 +Hashimoto thyroiditis 0.8401749663526317 1.286280564756336 0.1983451628298445 1.0 0.7037933568129499 2 Q15437 1 +Smooth muscle antibody positivity 0.8401749663526269 1.286280564756315 0.1983451628298518 1.0 0.7037933568129499 2 P49327 1 +Proximal muscle weakness 0.3327084732774712 1.285877287436212 0.1984858914863376 1.0 0.7037933568129499 62 Q9BQT8,P50402,P00846,Q16637,O60313,P35637,P35670,Q9H3H5,P13473,P10253,Q99720,Q13126,Q13510,P21912,P12235,P53007,P22626 17 +Tetraparesis 0.3857965445427012 1.28489285325526 0.1988297286984264 1.0 0.703803018919423 35 P00846,Q9NZJ7,P07602,P17900,Q9UBX3 5 +Abnormal lung development 0.3795092539815121 1.2843101362087903 0.1990334616110993 1.0 0.703803018919423 41 O95202,O75844,Q6NUK1,Q9H3H5,Q5JTZ9,Q9UHX1,Q14739,Q8TAA9,O96000,P21964 10 +Impaired temperature sensation 0.6060962738270369 1.2827705594903194 0.1995724713280662 1.0 0.703921782594402 6 Q9NR77 1 +Intellectual disability progressive 0.537685576161633 1.282266347280253 0.1997492288911742 1.0 0.703921782594402 10 Q9H9P8,P53701,Q15067 3 +Hemianopia 0.5950247999723443 1.275641598537969 0.2020822420256944 1.0 0.7087748968956967 7 P03886 1 +Abnormality of the metacarpal bones 0.3847971778820301 1.2749369695042445 0.2023315524371385 1.0 0.7088559475077981 35 Q96L58,Q32P28,P48651,Q96DX4,Q9UBM7,O95202,P16435,Q9NX62,Q6NUK1,O43924,P36776,P51798,Q14739,P51812,P16278 15 +Scrotal hypoplasia 0.4419729788508101 1.2738476003583763 0.202717431832226 1.0 0.7088559475077981 18 P46977,P16435,Q6NUK1,Q9BV10,Q8IY17 5 +Hypotension 0.4096324850926419 1.2738278785238435 0.2027244226932498 1.0 0.7088559475077981 24 Q9NZJ7,Q13423,P07602,P04062 4 +Dyskinesia 0.3296476681325035 1.2738077762471176 0.2027315485915632 1.0 0.7088559475077981 69 P35610,Q01105,P00846,P04062,O43819,Q9P0J0,Q15043,Q9NZ01,Q9UBX3,P03886,Q96N66 11 +Soft tissue sarcoma 0.4039181070128906 1.27244656874656 0.2032144969596068 1.0 0.7096061035131539 26 Q96DX4,P21912,Q13126,Q15392,Q15437 5 +Toxemia of pregnancy 0.6039099828522381 1.2718786539059226 0.2034162372703343 1.0 0.7096061035131539 6 Q14739,O43772 2 +Positional foot deformity 0.3392977721527557 1.2675454948066744 0.2049603069972732 1.0 0.710698225389983 81 Q9HC21,O95202,Q9NR77,Q8NCH0,Q96AY3,Q9NWM8,Q9Y487,Q6ZXV5,Q96A33,Q9UHX1,Q9BV10,P21964,Q8TAA9,Q9Y619,Q15392 15 +Chronic hepatic failure 0.701095360915304 1.267417049534476 0.2050062066328002 1.0 0.710698225389983 4 Q13043,Q10713 2 +Micromelia 0.4410199528484389 1.2665928332929386 0.2053009163399339 1.0 0.710698225389983 18 Q14739,O75718,Q15392,Q9UHX1 4 +Emphysema 0.5931796314260878 1.2662243010694776 0.2054327896215841 1.0 0.710698225389983 7 P06280,Q03518 2 +Abnormal aortic valve morphology 0.3837970809288199 1.2649673717636456 0.2058830244299341 1.0 0.710698225389983 35 Q6PGP7,P37268,P04062,Q9Y4P3,O75844,Q6NUK1,P06280,Q9UHX1,P21964,P51812 10 +Vascular tortuosity 0.8407109437081234 1.2648455640684195 0.2059266942826099 1.0 0.710698225389983 3 P00846 1 +Axial dystonia 0.8347913862718708 1.263451085397931 0.2064271149671983 1.0 0.7116533322504167 2 Q99720 1 +Adenoma sebaceum 0.6998333784057849 1.261859326923458 0.206999409781462 1.0 0.7116533322504167 4 Q15437 1 +Angiofibromas 0.6998333784057849 1.261859326923458 0.206999409781462 1.0 0.7116533322504167 4 Q15437 1 +Concentric hypertrophic cardiomyopathy 0.8398530445796766 1.261424951848316 0.2071557831596413 1.0 0.7116533322504167 3 P03886 1 +Chorioretinal atrophy 0.6990435254761533 1.258380749018061 0.2082540906485992 1.0 0.7116533322504167 4 Q9Y619 1 +Chorioretinal degeneration 0.6990435254761533 1.258380749018061 0.2082540906485992 1.0 0.7116533322504167 4 Q9Y619 1 +Macroglossia 0.3849012412143239 1.2575431608051562 0.2085570204534081 1.0 0.7116533322504167 32 Q96A33,Q10713,P10253,P21912,Q7LGA3,P16278,Q15437 7 +Paresthesia 0.4100159121679325 1.2556920579078987 0.2092276398266839 1.0 0.7116533322504167 23 Q9NZ08,P01889,P17050,Q9NR77,P54802,P06280,P49327,Q9H6K4 8 +Urinary bladder sphincter dysfunction 0.5574475549344271 1.2553439129775006 0.2093539404297377 1.0 0.7116533322504167 9 P22626,Q12768,O75298,Q9NR77 4 +Limited wrist movement 0.6972970708789501 1.2506890101100552 0.211047961577028 1.0 0.7116533322504167 4 O75844 1 +Loss of subcutaneous adipose tissue in limbs 0.6962962962963113 1.2462812993732064 0.2126611408833465 1.0 0.7124316364669655 4 P02545,O75431,O75844 3 +Aplasia hypoplasia involving bones of the thorax 0.3836699378143435 1.2455303835807463 0.2129368541662442 1.0 0.7124316364669655 32 Q96L58,Q12768,P48651,Q03164,O95155,P16435,Q96HY6,O75844,O75431,Q9UHX1,Q9BV10,Q14739,Q8TAA9,Q9Y619 14 +Abnormal proportion of cd4 positive t cells 0.6398288745210516 1.2455231368759 0.2129395161910907 1.0 0.7124316364669655 5 P49327,Q13432 2 +Oromandibular dystonia 0.59853242643325 1.2450696438564408 0.2131061513889345 1.0 0.7124316364669655 6 Q15043,P35637,Q99720 3 +Beaking of vertebral bodies 0.5309409412359436 1.2432112001191895 0.213790016537841 1.0 0.7124316364669655 10 Q96L58,Q9UM00,Q96DX4,P04066,P16278 5 +Knee flexion contracture 0.4005873428996933 1.2427329956056454 0.2139662407872029 1.0 0.7124316364669655 26 P37268,P23786,Q96AY3,Q86XL3,Q9H3H5,P21912,Q7LGA3 7 +Decreased cd4 cd8 ratio 0.6954146793068433 1.242398355463269 0.2140896221011698 1.0 0.7124316364669655 4 Q13432 1 +Retrocollis 0.8350723662066597 1.2423688981446213 0.2141004854268478 1.0 0.7124316364669655 3 O75569,Q99720 2 +Abnormality of the upper respiratory tract 0.3422382961909404 1.2407406566884465 0.2147015698673522 1.0 0.7124316364669655 87 Q96DX4,Q9NZJ7,P28070,Q86YV9,P16435,P54802,Q15165,P07602,Q9H0U3,Q13432,Q92804,Q9UHX1,Q9BV10,P21964,Q13510,P16278,Q03518,Q14739 18 +Retinal thinning 0.8294078061911263 1.2406466059105112 0.214736326941761 1.0 0.7124316364669655 2 P51648 1 +Vitritis 0.8294078061911259 1.24064660591051 0.2147363269417614 1.0 0.7124316364669655 2 P53701 1 +Photoreceptor layer loss on macular oct 0.8294078061911192 1.2406466059104813 0.2147363269417721 1.0 0.7124316364669655 2 Q96S66 1 +Abnormal optical coherence tomography 0.8294078061911192 1.2406466059104813 0.2147363269417721 1.0 0.7124316364669655 2 Q96S66 1 +Glomerular sclerosis 0.3906250254109967 1.238666143451893 0.2154691618381214 1.0 0.7137120444791618 29 O95470,Q14108,P03886,P21912 4 +Peptic ulcer 0.5050814577339522 1.2367971466881962 0.2161624016498953 1.0 0.7149775705741671 11 O76024,P04062 2 +Generalized hyperpigmentation 0.5540734552413076 1.2367846935629234 0.2161670260856967 1.0 0.7149775705741671 9 P51648 1 +Ankylosis 0.6377081911373285 1.235516613584997 0.216638297260326 1.0 0.7160132919669754 5 P16435,P48651,O75844 3 +Developmental regression 0.3672610644705597 1.23478049412544 0.2169122087705708 1.0 0.716395682941754 120 O75503,P13073,P17050,O95470,Q9Y4P3,P55795,P16278,Q9H9P8,O43681,P00846,Q9NZJ7,P07602,P17900,O75381,O14773,P06280,O76024,P49327,P21912,Q9Y5Y5,Q13510,O43819,P03886,Q9NZ08,Q15043,Q86VD7,Q15067,P40855 28 +Symptomatic seizures 0.5772077058859979 1.2336723947296868 0.2173250044661385 1.0 0.7172358747978684 8 Q16836,P40939,P53985,Q13423 4 +Abnormality of the autonomic nervous system 0.3554018722785374 1.2328548600493447 0.2176299192678243 1.0 0.7176522088838088 52 O15269,O43681,P42892,P04062,Q9NZJ7,Q6PJG6,P07602,Q15067,P06280,O76024,Q10713,P21964 12 +Abnormal skin morphology of the palm 0.3358347314606862 1.2317527919419728 0.2180414427589416 1.0 0.7176522088838088 80 Q9H3H5,P07858,Q9UHX1,Q15437,Q71SY5,O75381,Q14739,Q8NCH0,Q9Y487,P16615,P21912,Q9Y5Y5,P51812,P42167,O95202,Q6NUK1,Q06136,Q13043,P40855,Q8IY17 20 +Stillbirth 0.5041702048290367 1.2312132904097033 0.2182431019376149 1.0 0.7176522088838088 11 Q14739,O75844,P04062 3 +Sporadic 0.4132914940406827 1.2304445334173415 0.2185306855574846 1.0 0.7176522088838088 20 P21912,Q8WU17,O95202,P04062 4 +Anomalous trichromacy 0.8319972560703929 1.230116796200562 0.2186533712220244 1.0 0.7176522088838088 3 Q9H6K4 1 +Tritanomaly 0.8319972560703929 1.230116796200562 0.2186533712220244 1.0 0.7176522088838088 3 Q9H6K4 1 +Cortical cataract 0.831786862240651 1.2292786999298086 0.2189673305227542 1.0 0.7179464682165322 3 Q9H6K4 1 +Prominent superficial blood vessels 0.4855125859613131 1.2262998299266623 0.2200858653405561 1.0 0.7195298182397389 13 Q9Y487,O75844,Q6NUK1 3 +Abnormality of the coagulation cascade 0.3772031222311953 1.2247921721397528 0.2206535350690177 1.0 0.7208652285660262 38 Q9UJS0,Q4KMQ2,Q9Y487,Q5XKP0,Q96AA3,Q9H3H5,Q13043,Q9BV10,P38435,Q00059,Q9Y619 11 +Abnormal peripheral nervous system physiology 0.3646431580070899 1.2238657360299587 0.2210028811461801 1.0 0.7214859739220647 47 O15269,O43681,Q71SY5,Q9NR77,Q9NZJ7,O60313,O95831,O15121,P07602,Q9Y619,Q9NQZ5 11 +Epileptic spasm 0.3309298025561757 1.221549684404783 0.221877965962667 1.0 0.7223672778890072 61 Q01105,P13073,P00846,Q9H3H5,Q13510,Q9UBX3,P03886 7 +Brittle hair 0.4747262050345801 1.2200544672969185 0.2224442277747473 1.0 0.7223672778890072 14 Q6PGP7,Q9Y487,O75844,Q6NUK1,Q9NVI7 5 +Episodic respiratory distress 0.829350387075046 1.2195747964419992 0.2226261055566953 1.0 0.7223672778890072 3 P00846,P03886 2 +Abnormal uvea morphology 0.3397601363481705 1.21816107885306 0.2231627669078906 1.0 0.7223672778890072 86 Q9Y4P3,Q10713,Q9UHX1,Q86YV9,Q7LGA3,Q13586,P01889,O75381,Q9UBM7,P14174,P40939,P49327,P21912,Q9Y5Y5,O43505,Q9Y619,Q8N6S5,O95202,Q9NR77,P04439,Q5XKP0,Q13043,P53701,P40855,Q8IY17 25 +Abnormal cellular phenotype 0.3970930272708588 1.2173898193437764 0.2234559346787568 1.0 0.7223672778890072 166 Q9Y2R0,O75503,P13073,Q9UJS0,Q9UMS0,Q6PGP7,P09622,Q86Y39,Q9H0U3,P00403,Q70HW3,Q9UBX3,O96000,Q15437,Q16836,O75787,O43772,P00846,P04062,Q9NZJ7,O43676,Q9Y6M9,P51970,P07602,Q00325,O00483,Q92643,P11177,Q14739,P50542,Q96CU9,P15586,Q9BXW9,O14773,P14174,P23786,Q9P0J0,O75844,Q9NRZ9,P49327,P40939,P51798,Q96RP9,Q9BV10,P21912,Q3ZCQ8,Q13510,P28070,Q96J02,P03886,Q8N183,Q8IUX1,Q14108,Q15904,P09601,P35637,O75880,P02786,O75648,Q13043,P12235,P21964,Q4J6C6 63 +Flat face 0.407746032108536 1.217191793865362 0.2235312516804559 1.0 0.7223672778890072 22 Q96L58,Q9UM00,Q9Y5Y5,Q03164,Q9Y487,Q9NX62,P36776,O75381,P40855,P50542 10 +Epispadias 0.828720993098598 1.2170685985613152 0.2235781169380297 1.0 0.7223672778890072 3 Q9Y619 1 +Progressive hearing impairment 0.4927546585363432 1.2137016037878774 0.2248616917261938 1.0 0.72259919605151 12 O76024,P00403,P03886 3 +Tetraplegia 0.4926984864610472 1.213346904269874 0.2249972171287066 1.0 0.72259919605151 12 P51572,O95831,O43681,Q13423 4 +Focal onset seizure 0.3326668391016423 1.2112350015997562 0.2258053517190772 1.0 0.7228085300956238 78 O75503,Q01105,Q9NZJ7,P07602,Q6ZXV5,Q9H3H5,P54136,Q9NZ01,P21912,Q9UBX3,P03886,Q96N66 12 +Delayed cranial suture closure 0.3909401856430696 1.2106882709071176 0.2260148993265593 1.0 0.7228085300956238 28 Q8NCH0,O95155,P16435,Q9Y487,Q15436,O75844,O75381,O75718,P51812,P40855,Q32P28 11 +Cutis laxa 0.3908887700941682 1.210213635056253 0.2261969273731225 1.0 0.7228085300956238 28 Q96L58,P48651,Q8NCH0,Q9Y487,Q15904,Q9Y4P3,Q6NUK1,P51812,Q9BV10,P38435,O96000 11 +Vomiting 0.3435899735527417 1.204534500213781 0.2283830557121822 1.0 0.7282524480737753 92 P35610,Q9UJS0,Q86Y39,P00403,O96000,Q13423,P00846,Q9NZJ7,O43676,Q9Y6M9,P07602,Q9HCC0,Q9UBM7,Q2TAA5,Q96CU9,P23786,P11117,P06280,Q9Y619,P03886,Q8IUX1,Q9NSD9,P54136,P51571,P22695 25 +Cold induced muscle cramps 0.8252267012898087 1.203158828461996 0.2289148638200164 1.0 0.728456049670011 3 Q9NR77 1 +Malabsorption 0.3627814678630852 1.20312089576841 0.228929540344617 1.0 0.728456049670011 47 O75381,Q9Y5Y5,Q9NZ08,Q9Y4P3,P09601,P06280,P49327,O76024,Q96A33,Q14739,Q14566,P40855 12 +Abnormality of adrenal physiology 0.3931549814868046 1.202460558273352 0.2291851386134273 1.0 0.7285366512159753 27 O75381,O95470,P40855,Q9Y5Y5,Q13423 5 +Decreased number of peripheral myelinated nerve fibers 0.4629456593532901 1.2022242338810225 0.2292766625403632 1.0 0.7285366512159753 15 O15269,Q8TB36,P07196,Q96RL7,Q9NR77,O95140,P51149,P02545,Q9H0B6,P39210 10 +Short middle phalanx of finger 0.8244198574160972 1.1999480842107877 0.2301595037160733 1.0 0.729594561239647 3 Q9UHX1 1 +Hypoketotic hypoglycemia 0.5706405920670177 1.199253408802229 0.2304294255408194 1.0 0.729594561239647 8 P50416,Q16836,P31751,O43772,P23786,P40939 6 +Dyspnea 0.3439924649811835 1.1991930401272557 0.230452892907883 1.0 0.729594561239647 93 P53007,Q92804,Q9UHX1,P01889,P00846,P04062,Q9NZJ7,O95831,P51970,Q15165,P07602,Q00325,P23786,O75844,P06280,P10253,Q13510,O43819,Q9Y619,P03886,P35637,P12235,P53701,P51571 24 +Noncompaction cardiomyopathy 0.6855324664378818 1.1988754653829412 0.2305763730419467 1.0 0.729594561239647 4 P21912 1 +Abnormal macular morphology 0.3956011121285492 1.1981559275217086 0.2308563193606803 1.0 0.7299702612186874 26 Q13510,P51648,P04062,P50897 4 +Apnea 0.3348784946962067 1.1962745318227013 0.2315894440031005 1.0 0.7305023036445473 82 Q86Y39,Q9H3H5,Q96A33,Q10713,P00846,P04062,Q9NZJ7,P07602,Q6PJG6,O43924,Q96CU9,P23786,Q9P0J0,O76024,P51798,P51812,O43819,P03886,O60313,O75880 20 +Multicystic kidney dysplasia 0.431796508324012 1.196237358574147 0.2316039459641035 1.0 0.7305023036445473 18 Q9Y5Y5,Q8N6S5,Q10713,O75381,P40855 5 +Hypokinesia 0.4899631831677056 1.196068317281074 0.2316699001840922 1.0 0.7305023036445473 12 O95831,P12235,Q2TAA5,P04062 4 +Nyctalopia 0.3777620963331289 1.1924520133998566 0.2330840558992855 1.0 0.7332881636550735 33 Q9Y5Y5,Q9H3H5,Q13432,P40939,P40855,Q10713,P38435,O75381,Q6P4Q7,Q96S66 10 +Axonal degeneration 0.5786185977541167 1.1917919835660968 0.2333428198508023 1.0 0.7332881636550735 7 Q9BQT8,P17050 2 +Barrel shaped chest 0.6283369892023021 1.191281924244292 0.2335429275128326 1.0 0.7333442273079794 5 Q14739,Q32P28,P04066 3 +Increased c peptide level 0.8172947510094216 1.1894455800593078 0.2342643737015519 1.0 0.7336042184008229 2 P40939 1 +Hyperkeratosis 0.3494236781140576 1.1887689469750815 0.2345306008180996 1.0 0.7336042184008229 53 O15269,P42167,P04062,Q9NWM8,O75844,P16615,Q06136,P06280,P21912,P51648,Q15437 11 +Elevated gamma glutamyltransferase level 0.6831985274178181 1.1885982028209874 0.2345978154249981 1.0 0.7336042184008229 4 Q5XKP0 1 +Abnormal systemic blood pressure 0.3341388205394762 1.1862012913993814 0.2355428163871646 1.0 0.7352739217647773 82 P42892,P35610,O43681,P04062,Q9NZJ7,Q9Y4P3,O75844,P07602,Q9NSD9,P06280,Q13043,P00403,Q10713,P21912,P21964,Q8TAA9,Q13423,P03886 18 +Recurrent pharyngitis 0.8162853297442874 1.185186577915096 0.2359436855839589 1.0 0.7352739217647773 2 Q9BV10 1 +Anterior uveitis 0.8162853297442807 1.1851865779150672 0.2359436855839702 1.0 0.7352739217647773 2 P14174 1 +Hip osteoarthritis 0.8162853297442803 1.185186577915065 0.2359436855839711 1.0 0.7352739217647773 2 P51798 1 +Ambiguous genitalia 0.4301868239336197 1.1839343469582084 0.2364390525998703 1.0 0.7358048317334795 18 Q8TAA9,P16435,Q15392,P53701 4 +Breech presentation 0.5764439030338225 1.1806606075295911 0.2377375763603488 1.0 0.7383235567624552 7 O60313,Q9Y619,O75718 3 +Oculogyric crisis 0.495071325221203 1.1753850903795031 0.2398406857116706 1.0 0.7430615598172567 11 Q01105 1 +Skeletal dysplasia 0.367779597268821 1.174223345730498 0.2403055773559279 1.0 0.7430615598172567 42 Q96L58,O75381,Q9Y5Y5,P10619,Q96DX4,O95831,Q9HC07,Q15436,Q96HY6,P36776,P40855,Q14739,P51648,P38646,P16278 15 +Aplasia hypoplasia of the 5th finger 0.4775047221428898 1.1741385555740886 0.2403395324079622 1.0 0.7430615598172567 13 Q9UHX1 1 +Retinal degeneration 0.3525262718615387 1.1739648599154038 0.2404091010987661 1.0 0.7430615598172567 51 O75503,O14773,P04062,O60313,Q9NW15,Q10713,Q9UG56,P50897,Q13510,P51648,Q7LGA3,Q96S66 12 +Amelogenesis imperfecta 0.817233254796351 1.171369506502156 0.2414502838094088 1.0 0.744011581720958 3 Q6P4Q7,Q9HC07 2 +Vertebral wedging 0.8129205921938134 1.1709994794215868 0.2415989864014835 1.0 0.744011581720958 2 Q96AY3 1 +Progressive 0.3481520942364601 1.1704520052811105 0.2418191177701956 1.0 0.744011581720958 101 O00400,Q8N1F7,Q96RL7,O95470,P54802,P57740,P20700,Q13126,O94905,Q13586,P04062,Q9Y6M9,Q8NBU5,O95831,Q6PJG6,Q5JTZ9,Q9UHD9,Q99720,Q00059,O75569,P15586,Q5T160,Q9Y5Y5,Q13510,O75298,Q9Y3E5,Q8N183,Q12768,P27544,Q16637,O60313,O15121,Q15043,Q5XKP0,P12235,Q9NR28,P28288,Q8IY17,O75477 39 +Mediastinal lymphadenopathy 0.81656008078088 1.1686944880378378 0.242526743511493 1.0 0.744011581720958 3 Q9H0U3,Q01844 2 +Orchitis 0.8165600807808732 1.168694488037811 0.2425267435115039 1.0 0.744011581720958 3 Q9NZ08,P49327 2 +Neuroinflammation 0.8165600807808732 1.168694488037811 0.2425267435115039 1.0 0.744011581720958 3 Q9NZ08,P49327 2 +Pleuritis 0.8165600807808732 1.168694488037811 0.2425267435115039 1.0 0.744011581720958 3 Q9NZ08,P49327 2 +Pulmonary embolism 0.8165600807808732 1.168694488037811 0.2425267435115039 1.0 0.744011581720958 3 Q9NZ08,P49327 2 +Psoriasiform dermatitis 0.8165600807808671 1.1686944880377867 0.2425267435115137 1.0 0.744011581720958 3 Q15800,P10321 2 +Pectus excavatum 0.321799475786106 1.1662878139181692 0.2434980984893904 1.0 0.7455544065360485 69 P50402,Q9H490,P04062,Q03164,Q9Y487,Q8NCH0,Q9Y4P3,Q9NSD9,Q96A33,Q9UHX1,P21912,O75718,P51812,Q7LGA3,Q15437 15 +Orthostatic hypotension due to autonomic dysfunction 0.5409518681779847 1.1644799879998171 0.2442295486829397 1.0 0.7455544065360485 9 Q9NZJ7,P07602,P04062 3 +Abnormality of chromosome segregation 0.6225818988783283 1.1641091250207436 0.2443797911457721 1.0 0.7455544065360485 5 Q15437 1 +Vocal cord paresis 0.67744107744108 1.1632518630658757 0.2447273298538452 1.0 0.7455544065360485 4 O95140,P36776,P43243 3 +Abnormality of the ribs 0.3264757720100585 1.1628127653936948 0.2449054767455782 1.0 0.7455544065360485 61 Q96L58,P48651,Q03164,P54802,Q9UHX1,P16278,O95831,P16435,Q96HY6,Q9UBM7,O95155,Q14739,Q32P28,P15586,O75844,P51798,Q9BV10,Q8TAA9,Q9Y619,Q9UM00,Q12768,O95202,O75718 23 +Extrapyramidal muscular rigidity 0.58184311476629 1.1617356189694144 0.2453428726037598 1.0 0.7455544065360485 6 O75787,Q9H6K4,Q9BPX6 3 +Abnormal ureter morphology 0.3989984928994076 1.1614003213490605 0.2454791383684125 1.0 0.7455544065360485 23 Q9BXW9,P23786,Q9UJX6,O75844,Q16531,Q9H936,Q15058,P36776,O76024,Q8TAA9,Q7LGA3 11 +Abnormal metabolism 0.3587862026517453 1.1585196092342709 0.2466520541057864 1.0 0.7455544065360485 47 P46977,Q9Y487,Q15904,Q9NSD9,Q96AA3,Q9H3H5,Q9H0U3,Q8N511,P49327,Q13043,Q9BT22,P51571 12 +Abnormal autonomic nervous system physiology 0.3740708425691318 1.156008422522104 0.247677711913506 1.0 0.7471583474645939 33 P42892,O43681,P04062,Q9NZJ7,P07602,Q15067,P06280,O76024 8 +Muscular hypotonia of the trunk 0.3259619071657175 1.153835180307928 0.2485677479645902 1.0 0.7487911354582665 75 Q9HC21,Q9NZJ7,O60313,Q15043,Q6PJG6,P07602,Q6ZXV5,Q9H3H5,P17900,P35270,Q9NSD9,Q5XKP0,P54136,Q9NVI7,O75880,Q9BW92,Q2TAA5,Q96N66 18 +Abnormal circulating free fatty acid concentration 0.6750841750841833 1.152879177942308 0.2489599796330361 1.0 0.7489030372778626 4 Q16836,P40939,O75431 3 +Erythema 0.4038218547263594 1.1525794715735986 0.249083033158229 1.0 0.7489030372778626 20 Q06136,P00403,P22830,P53701,P51648,P03886 6 +Opisthotonus 0.3949941082340379 1.146751810672929 0.2514842107051174 1.0 0.7532289703273405 24 P04062,Q9NZJ7,O60313,P35637,P07602,P11117,Q9HCC0,Q99720,Q2TAA5 9 +Abnormal vitreous humor morphology 0.6188022160029731 1.1462631863424555 0.251686270341269 1.0 0.7532289703273405 5 P53701 1 +Abnormal myocardium morphology 0.386003240939211 1.1456763407549213 0.2519290968017922 1.0 0.7534576950584644 157 Q53H12,P17050,P09622,Q86Y39,P54802,Q9H061,Q9Y4P3,P00403,P13473,O96000,Q13423,P16278,P22626,Q16836,P01889,Q96DA6,P04062,P00846,O43676,Q9Y6M9,Q00325,Q5JTZ9,O95155,O75381,Q9BT22,Q96CU9,P23786,Q9P0J0,Q9BTV4,P06280,O76024,P49327,P40939,P10253,P21912,Q9NVI7,Q9Y5Y5,Q07021,O43819,P03886,P42167,P50402,Q9NZ08,Q9NWS8,Q8IUX1,Q14108,O60313,Q5XKP0,Q99797,P12235,P53701,P40855 52 +Thoracic kyphoscoliosis 0.5783240250651475 1.1441463011853876 0.2525629685142765 1.0 0.754356940259 6 O75844 1 +Abnormal bleeding 0.3429234594664981 1.141916291116493 0.2534888162774602 1.0 0.7548389649850801 97 Q9UJS0,Q6ZXV5,Q9H3H5,Q96AA3,P35670,Q9UHX1,Q13126,P04062,P38435,Q14739,P23786,Q8NCH0,Q9Y487,O75844,P11117,O76024,P49327,P21912,Q9NZ08,Q8N6S5,Q4KMQ2,Q14108,Q9NWM8,P21964 24 +Biparietal narrowing 0.513385770698253 1.141255699505848 0.2537635315459026 1.0 0.7549548428645512 10 O43924,Q10713 2 +Recurrent paroxysmal headache 0.5365943146121869 1.1404309476487091 0.2541068057213858 1.0 0.7554797218033058 9 P03886,P21912 2 +Coxa valga 0.4444809438983776 1.1389663335527065 0.2547171964247359 1.0 0.7567975494824174 16 Q96L58,O75844,Q96A33,P51812,Q9Y619,P16278 6 +Aplasia hypoplasia of toe 0.3888296897279418 1.1374540417893877 0.2553485265875599 1.0 0.7578318437692881 26 P13073,O95202,Q03164,Q9NX62,Q9UHX1,Q13510,Q7LGA3 7 +Eeg with spike wave complexes 0.4718635715986362 1.1373307544450375 0.2554000427544023 1.0 0.7578318437692881 13 Q14108,O75503,P53007,Q9NQZ5 4 +Abnormal circulating ferritin concentration 0.6714578312439552 1.136924391029995 0.2555698946680445 1.0 0.7578392161472858 4 P41440,P36551 2 +Thoracic hypoplasia 0.3935730416740831 1.1343734475637228 0.2566379320795979 1.0 0.7595140891872023 24 P04062,P16435,Q15436,P51798,Q96A33,Q9UHX1,Q14739,O75718 8 +Sea blue histiocytosis 0.8070561212469808 1.1309693917946575 0.2580679744957188 1.0 0.7602679170570038 3 O15118 1 +Aplasia hypoplasia involving the femoral head and neck 0.511520232177867 1.13040116329844 0.2583072241708746 1.0 0.7604779655693888 10 Q96L58,Q96DX4,O95831,Q96HY6,P50542 5 +Bilateral tonic clonic seizure with generalized onset 0.5345231244745434 1.1289951168291328 0.2588998936357711 1.0 0.7612329340147869 9 Q13510,P04062 2 +Exodeviation 0.4006387950390618 1.126348129791059 0.260018193001688 1.0 0.7630345935914734 20 Q9H3H5,O43819,P55795,Q9UHX1 4 +Abnormal exteroceptive sensation 0.3534778526886253 1.118467824952577 0.2633672408261989 1.0 0.770408089778173 48 O15269,Q9NZ08,P17050,Q9NR77,Q9NZJ7,Q8NCH0,P54802,P07602,P06280,P49327,Q9H6K4 11 +Anhidrosis 0.6672458983668362 1.118401719410568 0.2633954603215538 1.0 0.770408089778173 4 P20700,P04066 2 +Amyotrophic lateral sclerosis 0.4214981059407671 1.1174196421661655 0.2638149405853491 1.0 0.770408089778173 18 Q13501,P35637,Q15165,P09651,Q92804,P50995,Q9UHD9,Q99720,P43243,P22626 10 +Bilateral tonic clonic seizure with focal onset 0.8033856572520935 1.116422643237028 0.2642412655716117 1.0 0.770408089778173 3 P07602 1 +Aplasia hypoplasia of the lungs 0.3741089219980263 1.1144878040706574 0.2650699736792081 1.0 0.770408089778173 30 O95202,O75844,Q6NUK1,Q9H3H5,Q5JTZ9,Q14739,Q8TAA9,O96000 8 +Abnormality of the basal ganglia 0.3280240117864258 1.1139391891043249 0.265305275645324 1.0 0.770422324137481 81 Q96N66,Q71SY5,P00846,P04062,P23786,O60313,Q9P0J0,Q96AA3,Q9NZ01,P00403,O43819,P16278,P03886,Q96CU9 14 +Abnormal neuron morphology 0.3701878115346877 1.1102151613065518 0.2669063210378399 1.0 0.7720216558256267 31 P22307,Q5THJ4,Q16637,P35637,Q15165,P09651,Q92804,P50995,Q9UHD9,Q99720,Q13510,Q8IY17,P22626 13 +Adducted thumb 0.390776162583157 1.109992660353535 0.2670021892718488 1.0 0.7720216558256267 24 Q96L58,P34897,P42892,Q71SY5,Q8NBU5,Q8NCH0,Q9Y4P3,Q96AA3,Q86XL3 9 +Abnormality of fontanelles 0.3604013985072814 1.109301354558018 0.2673002009510847 1.0 0.7723901148095161 43 Q9Y5Y5,Q8NCH0,Q9Y487,P16435,Q15436,O75844,Q6NUK1,P40855,O75381,O75718,P51812,Q9BT22,Q9Y619 13 +Spondyloepimetaphyseal dysplasia 0.5304351728489761 1.1064159782926035 0.2685465127470308 1.0 0.7726258931325626 9 Q96L58,O95831,Q96DX4 3 +Deposits immunoreactive to beta amyloid protein 0.7974427994616451 1.105953006973875 0.2687468599124942 1.0 0.7726258931325626 2 O96008 1 +Finger agnosia 0.7974427994616451 1.105953006973875 0.2687468599124942 1.0 0.7726258931325626 2 O96008 1 +Abnormal circulating gaba concentration 0.7974427994616435 1.1059530069738688 0.2687468599124969 1.0 0.7726258931325626 2 P51649 1 +Hyperglycemia 0.5705085222148494 1.105072326961617 0.2691282504474914 1.0 0.7727411021092209 6 O75844 1 +Functional motor deficit 0.3741578999733622 1.1017215581949071 0.2705827416416984 1.0 0.7750003581769462 144 Q9HC21,Q9Y2R0,Q53H12,O43292,P35670,Q9H3H5,P00403,P13473,O43681,Q96DX4,P00846,P04062,Q9NZJ7,Q71SY5,Q9H2D1,P07602,Q99720,O14773,P23786,P40939,P21912,Q13510,O43819,O75298,P03886,Q15041,Q8IUX1,Q9NR77,Q9NWM8,P35637,Q15067,Q9NSD9,P54136,P12235,P53701,P53007,O75477 37 +Cerebral visual impairment 0.3211444639006502 1.0922605921062878 0.2747185764556232 1.0 0.7813603732355918 61 Q96N66,Q01105,P37268,Q9H490,Q9NZ01,Q96A33,P12235,P03886,Q96CU9 9 +Capillary malformation 0.4647826186760012 1.0910709967036194 0.275241643729148 1.0 0.782356662150397 13 Q9Y4P3,Q9UHX1 2 +Mutism 0.4646741839064426 1.0903621896616242 0.2755536304552439 1.0 0.7827520945428762 13 Q13510,P22626,P53701 3 +Weakness of facial musculature 0.3365857503100882 1.0894913210990596 0.2759372800217312 1.0 0.7833504726886514 55 Q9BQT8,Q9Y5Y5,O60313,Q15043,Q86VD7,Q9H3H5,P51812,P51798,P12235,Q9UHX1,O75381,Q13510,O43819,P40855 14 +Exaggerated startle response 0.5272999247512556 1.0890930757499933 0.2761128430602251 1.0 0.7833577402109644 9 P17900,P16278 2 +Arrhinencephaly 0.5267015423634718 1.0857864225258207 0.2775734947425041 1.0 0.7865161352903998 9 P21964 1 +Axonal degeneration regeneration 0.6595959595959586 1.0847893404816125 0.2780149677232955 1.0 0.7872744051601512 4 P02545,Q8TB36,O95140 3 +Decreased absent ankle reflexes 0.4458813152180746 1.0837391393246214 0.2784804766100697 1.0 0.7880997488064972 15 Q15041,O75787,Q96RL7,O60313,P12235,Q9H6K4 6 +Saccadic oscillation 0.7950185122854099 1.0833171579223366 0.2786676720616934 1.0 0.78813692635562 3 P51798,P04062 2 +Retinal arteriolar tortuosity 0.503149073407464 1.081662515224135 0.2794025150947861 1.0 0.7892293127568255 10 P21964,P00846 2 +Colorectal polyposis 0.5568589871387615 1.0803119358055266 0.2800032963784593 1.0 0.789940763863965 7 Q15437 1 +Decreased circulating total igm 0.5649394495355426 1.077227623458 0.2813785873496059 1.0 0.7915649905131065 6 P49327 1 +Renal hypoplasia 0.3765128492320209 1.0770608103699215 0.2814530995419835 1.0 0.7915649905131065 28 Q9NWS8,Q6PGP7,Q9Y4P3,O43924,Q15058,Q9UHX1,Q9UBM7,P21964 8 +Nevus 0.3695534507692576 1.0707566392912626 0.2842788681941222 1.0 0.7981602102596325 30 Q8N6S5,Q96AY3,Q9Y4P3,Q6NUK1,Q9UHX1,P21912,Q15437 7 +Hamartomatous polyposis 0.790502041309884 1.0654826307905887 0.2866575815458549 1.0 0.8017205245457883 3 Q15437 1 +Progressive external ophthalmoplegia 0.544908633979502 1.0640834613003458 0.2872908923535244 1.0 0.8024156203922224 8 P00403,P12235,P03886 3 +Intracranial hemorrhage 0.3894555380625121 1.0623617371127805 0.2880714971646307 1.0 0.803058349214441 22 Q9H3H5,P23786,O75844,P04062 4 +Subcutaneous hemorrhage 0.3629263024962506 1.062078503569453 0.2882000480285924 1.0 0.803058349214441 36 Q8N6S5,P04062,Q8NCH0,Q14108,Q9NWM8,P35670,P49327,P38435,Q13126,Q86YV9,P21964 11 +Preaxial polydactyly 0.4765555225615946 1.0614702454333378 0.2884762481266469 1.0 0.8033336110193465 11 O43924,Q9UHX1 2 +Abnormal aortic arch morphology 0.5440498107453535 1.0595676750157188 0.2893413260052266 1.0 0.80475277896294 8 Q9UHX1 1 +Angina pectoris 0.7885501906166372 1.0577835943158462 0.2901541138818402 1.0 0.8059610599315286 3 O75844 1 +Abnormal larynx physiology 0.4328861388728592 1.0557926531860382 0.2910629554921127 1.0 0.8059610599315286 16 P35637,Q15165,P09651,Q92804,Q9UHD9,Q13510 6 +Panniculitis 0.5606104430708894 1.055586265311936 0.2911572785628937 1.0 0.8059610599315286 6 P49327 1 +Stroke 0.3641721815915245 1.05423999081785 0.2917730551562369 1.0 0.8059610599315286 32 Q13586,P51970,Q9Y4P3,O75844,Q96AA3,Q9H3H5,P06280,P00403,O76024,P05067,P03886 11 +Abnormal atrioventricular valve physiology 0.3494732925301582 1.0541670535888434 0.291806441111448 1.0 0.8059610599315286 47 Q9NZ08,Q96DX4,P04062,Q15904,Q9Y4P3,O75844,Q6NUK1,P40939,P49327,P06280,P53701,O43819 12 +Diffuse optic disc pallor 0.7849932705249103 1.0539371535259088 0.2919116913179538 1.0 0.8059610599315286 2 Q9H3H5 1 +Atlantoaxial dislocation 0.784993270524909 1.0539371535259028 0.2919116913179564 1.0 0.8059610599315286 2 Q8NCH0 1 +Abnormal circulating aromatic amino acid concentration 0.6523526043973349 1.053007834296173 0.292337401508405 1.0 0.8065812045609713 4 P35270 1 +Motor neuron atrophy 0.3841951186033137 1.052541212874419 0.2925513124608672 1.0 0.8065812045609713 24 Q16637,P35637,Q15165,Q92804,Q99720,Q13510,P22626 7 +Abnormal vertebral morphology 0.3386031005064328 1.0515668569826828 0.2929983204352357 1.0 0.8065812045609713 100 Q96L58,P54802,Q9Y4P3,P36776,Q10713,Q9UHX1,P16278,Q96DX4,P04062,O95831,P16435,Q96HY6,Q15436,P04066,Q14739,Q9UBM7,Q32P28,P15586,Q8NCH0,Q96AY3,P51798,Q9BV10,Q8TAA9,P51812,Q9Y619,Q96J02,Q9UM00,P10619,O95202,Q14108,Q6NUK1,O75718,P38646 33 +Lissencephaly 0.3378186066721581 1.050013091066656 0.2937120939883044 1.0 0.8065812045609713 53 Q9HC21,Q9NWS8,P23786,Q9Y320,Q9Y487,Q6ZXV5,Q86XL3,Q9BV10,O43505,Q15392 10 +Skin ulcer 0.373549067099214 1.0495162991642952 0.2939405575937592 1.0 0.8065812045609713 28 Q14739,Q8IZA0,Q03518,P04062 4 +Abnormality of the achilles tendon 0.4583164289498128 1.0487875938229454 0.2942758886263104 1.0 0.8065812045609713 13 P50402,Q15041,O60313,Q9BTV4,Q8N2K0,Q9Y3E5 6 +Aplastic clavicle 0.7836473755047227 1.0483326475390935 0.2944853729353527 1.0 0.8065812045609713 2 Q9Y619 1 +Diaphyseal thickening 0.7836473755047209 1.048332647539085 0.2944853729353567 1.0 0.8065812045609713 2 Q14739 1 +Humeroradial synostosis 0.7836473755047142 1.048332647539058 0.2944853729353691 1.0 0.8065812045609713 2 P16435 1 +Elbow ankylosis 0.7836473755047142 1.048332647539058 0.2944853729353691 1.0 0.8065812045609713 2 P16435 1 +Bifid scrotum 0.5590374932153608 1.0477241625441327 0.294765711808616 1.0 0.8065812045609713 6 Q9UBM7,O60566,P16435 3 +Hyporeflexia of upper limbs 0.7859744520586835 1.0476317999486962 0.2948082803772984 1.0 0.8065812045609713 3 Q9NR77 1 +Increased muscle lipid content 0.5192571791542947 1.044641075006027 0.2961888880894869 1.0 0.8087355555615794 9 O75648,Q8NI60,P23786 3 +Hypoplastic female external genitalia 0.47376940803992 1.0443080748428568 0.2963428781501105 1.0 0.8087355555615794 11 Q9Y619,Q6NUK1 2 +Thickened ribs 0.6502857301019034 1.0439485351108095 0.2965092011001573 1.0 0.8087355555615794 4 P54802 1 +Bradycardia 0.4659078041037794 1.043702502067536 0.2966230518797599 1.0 0.8087355555615794 12 P51970,Q9BTV4,Q6PJG6,O75880,O43464,O75208 6 +Abnormal bone structure 0.3851621857476762 1.0420285383951875 0.2973984479526841 1.0 0.8097535612325638 168 Q9HC21,P17050,O43292,P54802,Q9Y4P3,P35670,Q9H3H5,Q15058,Q13126,P16278,Q15437,P22626,Q96DX4,P04062,Q9H490,Q9NZJ7,O95831,Q9HC07,P07602,Q86XL3,P38435,Q14739,O75381,Q9UBM7,Q9UG56,Q15392,Q96AY3,Q9Y487,O75844,P06280,Q9BV10,P21912,Q9Y5Y5,Q13510,Q9Y619,Q8N6S5,O95202,Q14108,Q9NWM8,Q15043,Q9NSD9,Q6NUK1,Q13043,P12235,O75718,P40855 46 +Osteopetrosis 0.7839111410299403 1.0395065889485744 0.2985691952973193 1.0 0.8111546057447824 3 P51798,Q15392 2 +Tissue ischemia 0.4008832316474057 1.0387752946684086 0.2989092537938558 1.0 0.8111546057447824 19 Q9NZ08,P01889,Q9Y4P3,O75844,P06280,P49327 6 +Joint stiffness 0.3389525808630631 1.0386063281268147 0.2989878615256276 1.0 0.8111546057447824 52 P50402,P01889,Q8NBU5,Q96AY3,P16435,Q9Y4P3,P54802,O75844,O76024,O95155,Q8TAA9,P51648,P16278 13 +Ulnar deviation of the wrist 0.6488140576277659 1.0375009037255087 0.2995024747564119 1.0 0.8111575393388434 4 P16278,Q9BV10 2 +Gowers sign 0.456588940515868 1.0374870611122466 0.2995089227145791 1.0 0.8111575393388434 13 Q13510 1 +Agenesis of cerebellar vermis 0.6485735783377988 1.0364475584275927 0.2999933928260097 1.0 0.8111575393388434 4 O43924 1 +Posteriorly rotated ears 0.3351315107584905 1.0360691921780278 0.3001698636533145 1.0 0.8111575393388434 97 Q9Y4P3,Q10713,Q9UHX1,Q7LGA3,P04062,Q9H490,P16435,Q9HC07,O43924,O75381,Q15392,P42892,P37268,P23786,Q8NCH0,Q9Y5Y5,O43505,Q9Y619,O95202,Q6NUK1,P40855,Q8IY17 22 +Delayed epiphyseal ossification 0.6483788525150996 1.035594670805204 0.3003912792387591 1.0 0.8111575393388434 4 Q96L58,Q9UG56 2 +Falls 0.517330389904806 1.0339905211901692 0.3011405945392411 1.0 0.8117684570398183 9 Q9BQT8,O75787,Q96RL7,P54886,Q5T8D3,P21912 6 +Orthostatic hypotension 0.4469936814586389 1.033086715509224 0.3015633196005454 1.0 0.8120908773061042 14 P07602,P04062 2 +Hip pain 0.5944667717908754 1.0314711574303836 0.3023199269975336 1.0 0.8125319862788014 5 P09651,O75844,P22626 3 +Multiple lipomas 0.5942753322220342 1.0305695602088476 0.3027427167601306 1.0 0.8125319862788014 5 O95140,Q8TAA9 2 +Aortic regurgitation 0.3856709127819964 1.0302236424323636 0.3029050337541115 1.0 0.8125319862788014 22 Q9NZ08,O75844,Q6ZXV5,P49327,Q9UHX1 5 +Biliary atresia 0.7789367429340592 1.0287484811618366 0.3035978816411071 1.0 0.8129092190738417 2 Q10713 1 +Abnormal nerve conduction velocity 0.3580719142668355 1.027833745534625 0.3040280395769792 1.0 0.8129092190738417 38 O15269,O43681,Q71SY5,Q9NR77,Q9NZJ7,O95831,O15121,P07602,Q9Y619 9 +Equinovarus deformity 0.5549001341404839 1.0270491233714143 0.3043973335417314 1.0 0.8131629063580883 6 P40939,Q9NR77 2 +Incomplete penetrance 0.3678368776613267 1.024006112270819 0.3058323879141318 1.0 0.8153673771130886 29 P03886,O14979,P00846,P21912 4 +Hyporeflexia 0.3471558786422432 1.0237722958896005 0.3059428387180074 1.0 0.8153673771130886 114 O15269,Q9HC21,P35610,O14979,P54802,Q8N2K0,P41440,Q9H3H5,Q10713,P05023,Q13586,O43681,Q71SY5,P00846,P04062,Q9NZJ7,O95831,P07602,Q99720,P40939,P51649,O43505,P03886,Q9NWS8,Q9NR77,Q16637,P35637,Q15067,P12235,Q8IY17,P53007 31 +Status epilepticus 0.3497334942366553 1.023101169864588 0.3062600138890168 1.0 0.8154815478728935 45 Q13510,P42892,Q01105,Q9NZJ7,Q9Y487,P07602,P53701,P05023,Q15392 9 +Impaired visuospatial constructive cognition 0.592444869542579 1.0219505547749943 0.3068043032501015 1.0 0.815996708835081 5 P00403,P03886 2 +Delayed puberty 0.3462348411369493 1.0177715327548933 0.3087865435207686 1.0 0.8188785803286178 47 Q9UJS0,P04062,Q14108,Q15800,O75844,P06280,O76024,Q9NVI7,Q8IY17 9 +Aplasia hypoplasia of the ribs 0.3841186370647923 1.0170356907828095 0.3091364510709873 1.0 0.8188785803286178 22 Q14739,Q9Y619,Q9BV10,Q9UHX1 4 +Stuttering 0.7778771025783942 1.0157824442256838 0.309732997850777 1.0 0.8188785803286178 3 P03886 1 +Hemoptysis 0.6436921411516858 1.0150809179340927 0.3100672568958662 1.0 0.8188785803286178 4 Q9NZ08,P49327 2 +Recurrent sinusitis 0.5908765134501408 1.014568249823581 0.3103116805134034 1.0 0.8188785803286178 5 Q13432 1 +Recurrent fever 0.4689159693311861 1.0144070291982648 0.3103885715901386 1.0 0.8188785803286178 11 P28070,Q13510,P51572,Q9NR77 4 +Paralysis 0.3442105440762729 1.013361012073933 0.3108877548390993 1.0 0.8192986783789552 48 Q9HC21,P20700,P36776,Q92804,P50995,P04062,Q15165,O95140,P17900,Q9UHD9,P02545,Q02978,Q9BTV4,P51798,P36551,P10253,P21912,P50402,Q9NR77,P35637,P54136,P09651,P43243 23 +Generalized osteosclerosis 0.7771255070660402 1.0128314928256548 0.3111406553453562 1.0 0.8192986783789552 3 Q15392 1 +Motor deterioration 0.5904732014971175 1.0126702430056642 0.3112176958506631 1.0 0.8192986783789552 5 P21912 1 +Abnormality of the intrahepatic bile duct 0.64263069304467 1.010438818454198 0.312285097747194 1.0 0.8197640262943994 4 Q10713,P50542 2 +Limited elbow movement 0.3593867620425598 1.0104173548528848 0.3122953765595777 1.0 0.8197640262943994 33 Q96L58,P50402,Q96DX4,P37268,P23786,Q96AY3,P16435,Q9BTV4,Q9H6K4,Q96J02,Q7LGA3 11 +Postaxial hand polydactyly 0.468231394611652 1.010189372248621 0.312404570059078 1.0 0.8197640262943994 11 Q9UBM7,Q10713,O43924,Q14739 4 +Impaired glucose tolerance 0.6423991382900839 1.0094263442356788 0.3127702093989466 1.0 0.8197640262943994 4 P02545,O76024 2 +Metaphyseal striations 0.5895298587578579 1.0082314790224691 0.3133433490623316 1.0 0.8197640262943994 5 Q13126 1 +Short femur 0.5505626993261362 1.0053840959983935 0.3147119349756977 1.0 0.8207844313145592 6 Q9BV10,Q9UHX1 2 +Hyperactive deep tendon reflexes 0.5421960122295961 1.0051628732681412 0.314818429256372 1.0 0.8207844313145592 7 Q9NR77 1 +Abnormal tongue physiology 0.4258242356950567 1.0050689731144884 0.3148636389561372 1.0 0.8207844313145592 16 Q9BQT8,Q9NWS8,Q16637,O95831,P10253,Q13510 6 +Pectus carinatum 0.3593898689876288 1.0045920463984244 0.3150933286669752 1.0 0.8209105823958941 31 P53007,Q71SY5,Q96AY3,P55795,Q9NVI7,P17480,P51812,Q9Y619,P16278 9 +Hemivertebrae 0.4593790234389778 1.0022811769374638 0.31620781094876 1.0 0.8227610676395706 12 Q9UHX1 1 +Atlantoaxial abnormality 0.5881794188716745 1.0018788279374815 0.3164021193031603 1.0 0.8227610676395706 5 Q9NWM8 1 +Impaired tactile sensation 0.5412160643870401 1.0001432639993015 0.317241181441843 1.0 0.8228011494016535 7 Q9NR77 1 +Hypoplastic labia majora 0.5325644550780374 0.9991819609360733 0.3177065527967462 1.0 0.8228011494016535 8 Q9Y619,Q6NUK1 2 +Abnormal labia majora morphology 0.5325644550780374 0.9991819609360733 0.3177065527967462 1.0 0.8228011494016535 8 Q9Y619,Q6NUK1 2 +Abnormality of fundus pigmentation 0.772763979500655 0.9957260853269748 0.3193832522305053 1.0 0.8228011494016535 3 Q9Y619 1 +Hypopigmentation of the fundus 0.772763979500655 0.9957260853269748 0.3193832522305053 1.0 0.8228011494016535 3 Q9Y619 1 +Wormian bones 0.4331905734393013 0.9954050568014 0.3195393001643167 1.0 0.8228011494016535 15 Q96AY3,O95831,Q9Y487,O75844,O75718 5 +Elbow flexion contracture 0.3811657071066778 0.9919399553299384 0.3212268168529815 1.0 0.8251250809778674 22 Q96L58,P50402,P37268,P23786,Q96AY3,P16435,Q9BTV4,Q7LGA3 8 +Abnormal circulating dicarboxylic acid concentration 0.3537519632704464 0.9918582495995396 0.321266677951409 1.0 0.8251250809778674 39 Q9H9P8,Q9UJS0,Q96DA6,P37268,P23786,Q9NSD9,P41440,O75648,Q14739,P28288,P40855,P22695 12 +Severe muscular hypotonia 0.3643297913838368 0.9908104750302112 0.3217781333957463 1.0 0.8254761317122999 29 Q9Y5Y5,Q9NWS8,Q01105,O95831,Q9NWM8,O75381,P40855,O43505 8 +Deep plantar creases 0.5857420127610384 0.9904181335654024 0.3219697857051009 1.0 0.8254761317122999 5 P61978,Q9Y487,P42345 3 +Occipital meningocele 0.6379205043923923 0.989858193508769 0.3222434361632835 1.0 0.8254761317122999 4 P21964 1 +Abnormal visual fixation 0.5390337060914119 0.9889665763450366 0.3226794949493752 1.0 0.8254761317122999 7 P04062 1 +Neoplasm of the tongue 0.5850581457604838 0.9872038489681136 0.3235427152962387 1.0 0.8272170609042172 5 O43924 1 +Thickened skin 0.3299397797863662 0.986616331078774 0.323830761120524 1.0 0.8274862789806617 95 O15269,O95470,Q15800,Q9H3H5,P16278,Q15437,P04062,O75381,Q14739,O75844,P16615,P06280,P21912,Q9Y5Y5,P28070,P51648,P42167,P50402,Q9NWM8,Q06136,P40855 21 +Hyperconvex nail 0.5300953019151142 0.9862049141774778 0.3240325683127629 1.0 0.8275349516752344 8 P51812,P42892,Q9Y619,O95202 4 +Eeg with focal spikes 0.7699857767759423 0.9848479122761472 0.3246987820531255 1.0 0.8287689318695335 3 O75503 1 +Talipes calcaneovalgus 0.5844492999499359 0.9843426598816186 0.3249470609761804 1.0 0.8288362924181575 5 Q9UBM7,Q9NR77 2 +Abnormal circulating bilirubin concentration 0.3763228949147367 0.9837025856023762 0.3252617681554017 1.0 0.8288362924181575 24 Q9UJS0,P23786,Q9NSD9,P41440,O75648,Q14739,P28288,P40855 8 +Large placenta 0.768160535359679 0.977708898266454 0.3282183195470067 1.0 0.8337195838319107 3 O75844 1 +Thin skin 0.3771492839445179 0.9733722868550418 0.3303683073046159 1.0 0.8366900545169274 23 Q6ZXV5,Q9Y619,O75844 3 +Jaundice 0.3293276421289007 0.9733304486768032 0.3303890939656064 1.0 0.8366900545169274 54 O75381,Q9Y5Y5,Q9UJS0,Q6PGP7,O15118,Q15904,Q9H3H5,Q13043,P40855,Q14739,P00374,Q00059,Q15437 13 +Vertebral compression fracture 0.4378617451755757 0.9713803125139956 0.3313589286435185 1.0 0.8369409755782914 14 P04062,Q96AY3,Q14108,O75718,Q32P28 5 +Abnormality of the amniotic fluid 0.3151734121024282 0.9713115077530506 0.3313931799651282 1.0 0.8369409755782914 78 Q6PGP7,Q15058,Q70HW3,Q9UHX1,Q7LGA3,P04062,P16435,Q9UBM7,Q14739,Q9BT22,P23786,O75844,P40939,P51798,Q9BV10,Q9NVI7,Q9NSD9,Q6NUK1,P21964,P38646 20 +Abdominal distention 0.3814801561177645 0.9680648794919586 0.3330119684561037 1.0 0.8400435616541714 20 O43681,P04062,Q9NZJ7,Q96HY6,P07602,O75648,Q01844 7 +Optic nerve dysplasia 0.7641318977119891 0.9675506445759718 0.3332688366041367 1.0 0.8402226465578765 2 O43505 1 +Aplasia hypoplasia of the skin 0.3329388032212099 0.9671799473766112 0.3334540847757297 1.0 0.8402226465578765 52 Q8NCH0,Q9NWM8,O75844,Q6ZXV5,P53701,Q13126,Q9Y619,Q15392 8 +Coronal craniosynostosis 0.5427180270633307 0.966236798238022 0.3339257033385987 1.0 0.8407137433008357 6 Q9NX62,Q6NUK1 2 +Decreased facial expression 0.372084943294503 0.9655910047062912 0.3342488782364317 1.0 0.8407137433008357 25 P35270,P12235,P04062 3 +Iris coloboma 0.367173740572213 0.9651217758111608 0.3344838212208785 1.0 0.8407137433008357 27 O95202,Q10713,P53701,Q9UHX1,O43505,Q8IY17 6 +Abnormal cranial nerve morphology 0.3167586962241355 0.963510449740758 0.3352914226227399 1.0 0.8407137433008357 59 P48651,Q9H3H5,Q9UHX1,P22626,O75381,P50542,Q02978,P34897,P07196,P51798,P21912,Q9Y5Y5,Q13510,P51812,O43819,Q9Y3E5,Q15043,P09651,P12235,P40855,P53007 21 +Asymmetric septal hypertrophy 0.7631224764468465 0.9633993610921529 0.3353471468208249 1.0 0.8407137433008357 2 P54802 1 +Polar cataract 0.7643890945809376 0.96297816365737 0.3355584817127581 1.0 0.8407137433008357 3 P08670,Q7LGA3 2 +Elevated circulating long chain fatty acid concentration 0.7643890945809353 0.96297816365736 0.3355584817127632 1.0 0.8407137433008357 3 P40855,P23786 2 +Metaphyseal cupping 0.764389094580935 0.962978163657359 0.3355584817127637 1.0 0.8407137433008357 3 Q14739,O95831 2 +Short ribs 0.5038320208778824 0.959400573794736 0.3373569861591989 1.0 0.8409492409999849 9 Q14739,Q9Y619 2 +Slow saccadic eye movements 0.4819918064408172 0.9584049189748046 0.3378586157782401 1.0 0.8409492409999849 10 Q96RL7,Q6PI48,Q8IV08,P04062 4 +Premature rupture of membranes 0.5410655678346944 0.9579979690655664 0.3380637826687267 1.0 0.8409492409999849 6 O75844 1 +Oral pharyngeal dysphagia 0.4596635459723119 0.95741207315238 0.338359307050506 1.0 0.8409492409999849 11 Q01105 1 +Dilatation of the cerebral artery 0.5245906486857848 0.9572866603044003 0.3384225865124879 1.0 0.8409492409999849 8 P10253,P38435 2 +Decreased calvarial ossification 0.6302071828154456 0.9562290694208634 0.3389565164816828 1.0 0.8409492409999849 4 O75844 1 +Abnormal pelvis bone morphology 0.7619755186303848 0.953566040935601 0.3403033522343239 1.0 0.8429395945935552 3 Q96DX4 1 +Abnormal patella morphology 0.3747977446656332 0.953091188633718 0.3405438701871999 1.0 0.8430378946353455 23 Q96AY3,Q9NX62,Q6ZXV5,P21964,Q9Y619 5 +Absent nipple 0.7604306864064672 0.9523436318493788 0.3409227366042588 1.0 0.8430378946353455 2 Q6NUK1 1 +Muscle fiber atrophy 0.3898901902728782 0.9512328553720866 0.3414861833321021 1.0 0.8430378946353455 19 P50402,Q13586,P23786,P35637,Q9BTV4,Q99720,P53007,P22626 8 +Chronic diarrhea 0.4092412448210369 0.9505507038520632 0.3418325032134484 1.0 0.8430378946353455 17 Q13510,Q15904,Q96A33,Q9BT22 4 +Decreased circulating cortisol level 0.5394713726402336 0.9500525097212884 0.3420855721419569 1.0 0.8432027602932939 6 Q13423 1 +Abnormality of the supraorbital ridges 0.3789721823510349 0.94732000977109 0.3434757375370973 1.0 0.8461095090849129 20 Q9Y5Y5,Q6PGP7,P16435,Q15436,Q6NUK1,O75381,Q9Y4W2,P51812,P40855 9 +Parkinsonism with favorable response to dopaminergic medication 0.4800330061008508 0.947000435054528 0.3436385572453964 1.0 0.8461095090849129 10 P07602,P04062 2 +Hepatic encephalopathy 0.7600134634802971 0.9459236381941688 0.344187535862591 1.0 0.8465405553426464 3 P09622,Q9UJS0 2 +Abnormality of the radioulnar joints 0.7597396141979963 0.9448576190401192 0.3447315708145422 1.0 0.8467714765895193 3 P16435 1 +Radioulnar dislocation 0.7597396141979963 0.9448576190401192 0.3447315708145422 1.0 0.8467714765895193 3 P16435 1 +Distal amyotrophy 0.3269070728291086 0.9438610165536128 0.3452406753466972 1.0 0.8472048034683846 54 O15269,Q96RL7,Q8N2K0,Q96BR5,Q15120,P39210,Q71SY5,O95140,Q99720,P02545,Q9BQT8,Q8TB36,P07196,Q13501,P04792,Q9NVI7,P21912,Q9H0B6,Q13510,Q9Y3E5,Q5THJ4,Q9NR77,P35637,P43243,Q8IY17,P53007 26 +Xerostomia 0.4172003929060614 0.9431104076790098 0.3456244327958819 1.0 0.8472048034683846 16 P35637,Q15165,P09651,Q92804,Q9UHD9,Q14739 6 +Hepatomegaly 0.3739202345090663 0.9416055232372728 0.3463946409132277 1.0 0.8482828199324473 162 Q9HC21,P35610,Q9UJS0,P17050,Q6PGP7,Q96RL7,P09622,Q86Y39,P54802,Q96AA3,Q9H3H5,P35670,Q9H0U3,Q96A33,Q10713,Q01844,O96000,P16278,O75787,O43772,P00846,P04062,Q9NZJ7,O43676,P49411,Q9Y6M9,Q9HC07,Q96HY6,P07602,Q9UGP8,P04066,Q14739,O75381,Q9BT22,P50542,Q96CU9,P15586,P14174,P23786,Q6NUQ1,P40939,P49327,P51798,Q96RP9,P10253,P20674,Q9Y5Y5,Q13510,Q07021,P28070,Q9Y619,Q9NVI7,P03886,Q96J02,Q8N183,Q9NWS8,Q8IUX1,O15118,Q14108,Q16625,Q15904,P09601,Q15067,P00374,O75880,Q13043,O75648,P28288,P40855,P53007 70 +Hyperreflexia in upper limbs 0.5002449540011944 0.9395957179519964 0.3474249735604859 1.0 0.8485114780376917 9 P21912 1 +Abnormal liver physiology 0.6261505497249467 0.9385837890685432 0.3479444790793264 1.0 0.8488645480987016 4 Q13510 1 +Abnormal cardiac test 0.4075577270841203 0.938053337036675 0.3482170005265539 1.0 0.848951550206025 17 Q16836,Q96DA6,P40939,Q9H3H5,P12235,P10253 6 +Abnormal iliac wing morphology 0.4492109462740845 0.937784595124074 0.3483551193204051 1.0 0.848951550206025 12 Q96L58,O95831,Q15436,Q8TAA9,P51812,P16278 6 +Abnormality of the calf 0.3262167527262541 0.935452501634809 0.3495551508419181 1.0 0.8509600661355943 54 Q96DX4,Q9NR77,O95831,P16435,Q9Y4P3,Q9NX62,Q9Y619,Q9BV10,Q13126,O75718,Q7LGA3,P16278 12 +Abnormality iris morphology 0.3041008671720858 0.9333870172853612 0.3506201811233971 1.0 0.8519593830888595 68 Q9Y5Y5,Q8N6S5,O95202,Q9NR77,Q9Y4P3,Q10713,Q9UHX1,P21912,O75381,Q86YV9,P53701,P40855,Q7LGA3,Q8IY17,O43505 15 +Weak cry 0.5199942997354107 0.9331577411847128 0.3507385300110526 1.0 0.8519593830888595 8 O75208,O60313,Q13510 3 +Fulminant hepatic failure 0.7566475934028882 0.9328325824187488 0.3509064155169441 1.0 0.8519593830888595 3 Q16836,P40939 2 +Degeneration of the lateral corticospinal tracts 0.5197641491832472 0.931950061161666 0.3513623343201453 1.0 0.8521524637394847 8 O00400,O75298 2 +Premature birth 0.3493760553602553 0.9304815933421252 0.3521217900361233 1.0 0.8530805057696984 37 Q9Y5Y5,Q9UBM7,P04062,O43676,O75844,Q9BV10,O75381,P40855 8 +Coarse hair 0.4063963995382106 0.9294332668407896 0.3526645941971082 1.0 0.8539386537564204 17 Q9UM00,Q9Y487,P54802,Q15436,Q6NUK1,Q96A33,P51812 7 +Abnormality of the spleen 0.3353771282905745 0.9247577259613856 0.3550919447178506 1.0 0.8561093961279753 108 Q9UJS0,Q6PGP7,P54802,P35670,Q9H0U3,Q96A33,Q10713,P16278,Q15437,P04062,Q9NZJ7,P07602,Q14739,Q9BT22,Q15392,P14174,P49327,P51798,P10253,Q13510,P28070,Q9NZ08,P10619,O15118,O95202,Q14108,Q15904,Q13043,P21964 29 +Dysphagia 0.3477788841997908 0.9240999699198984 0.3554342689729599 1.0 0.8561093961279753 125 Q03164,P35670,Q9UHX1,P01889,Q8IZA0,Q01105,P00846,P04062,Q9NZJ7,P07602,Q9H936,Q9UHD9,Q99720,O95155,Q14739,O75569,O76024,P21912,Q9Y5Y5,Q13510,O43819,P05067,P03886,Q8N183,O15118,Q9NR77,Q14108,O60313,P35637,Q15067,P54136,P12235,P17480,P53007 34 +Optic atrophy 0.3762761354488296 0.923089066995252 0.3559607916590321 1.0 0.8561093961279753 168 Q9HC21,P17050,O43292,Q86Y39,Q9H061,Q8N2K0,Q6ZXV5,P41440,Q53FT3,Q9H3H5,P00403,P50897,P16278,Q9H9P8,P01889,O43681,Q96DA6,P00846,Q9H490,Q9NZJ7,Q15436,P07602,Q6PJG6,O75381,Q9UBM7,P51572,Q6P4Q7,Q96CU9,Q9P0J0,P06280,O76024,P51798,Q9H6K4,O43505,Q9NVI7,O43819,Q9Y5Y5,P51812,P03886,O95202,O60313,Q15043,Q15067,Q5XKP0,P21964,P40855,Q8IY17 47 +Laryngeal dystonia 0.7540963070988989 0.9229265993888852 0.3560454577817373 1.0 0.8561093961279753 3 O75569 1 +Abnormal endocrine physiology 0.5711938228401012 0.9221812424455348 0.3564340455257568 1.0 0.8561093961279753 5 Q13423 1 +Neurogenic bladder 0.5257100695817015 0.9208179685007166 0.3571454721417766 1.0 0.8561093961279753 7 O76024 1 +Arterial thrombosis 0.5708312233599458 0.9204848420076608 0.3573194505878727 1.0 0.8561093961279753 5 Q9NZ08,P49327 2 +Weakness due to upper motor neuron dysfunction 0.3523395958225067 0.919038727712861 0.3580753159025585 1.0 0.8572964229631405 132 O00400,P17050,P00403,Q9UBX3,Q13423,Q9H9P8,O43681,P00846,P04062,Q9NZJ7,O95831,P07602,P17900,Q96CU9,Q9P0J0,P49327,P21912,Q9H6K4,Q13510,Q9Y5Y5,O75298,Q9Y619,P03886,Q15041,Q9NZ08,O60313,Q5XKP0,Q8IY17 28 +Broad palm 0.5252443631705033 0.918439438405084 0.3583888513299653 1.0 0.8572964229631405 7 Q14739,O95831 2 +Corneal erosion 0.5703183607986859 0.9180858544710528 0.3585739198984592 1.0 0.8572964229631405 5 P51648,P01889,Q96EK5 3 +Encephalopathy 0.3272545256778811 0.918045053340178 0.358595279393151 1.0 0.8572964229631405 98 Q9UJS0,P09622,Q86Y39,Q9H3H5,P00403,O96000,Q16836,P04062,Q9NZJ7,O43676,Q8NBU5,Q9Y6M9,P07602,Q9H936,Q96CU9,P23786,P40939,Q9NVI7,Q3ZCQ8,Q9Y619,P03886,O75746,Q8IUX1,Q15067,P08574,Q13043,O75208,P53007 28 +Coxa vara 0.4381096072926247 0.916607733995186 0.3593482301797155 1.0 0.8577378947041391 13 Q96DX4,Q96AY3,O95831,Q9Y487,Q96HY6,O75718 6 +Abnormality of facial musculature 0.308649876823941 0.9153986327347784 0.3599823959098018 1.0 0.8579779032162445 75 Q9BQT8,Q9Y5Y5,P04062,O60313,Q15043,Q86VD7,Q9H3H5,P35270,P51798,P51812,P10253,Q9UHX1,P12235,O75381,Q13510,O43819,P40855 17 +Abnormality of pancreas physiology 0.3472074452990953 0.915332257342765 0.360017229706463 1.0 0.8579779032162445 38 Q9NZ08,P53985,Q9UJS0,Q15904,P09601,P49327,P00403,Q9UHX1,Q14739,P03886 10 +Muscle fiber tubular inclusions 0.5694374799609309 0.9139665461190164 0.3607344245023665 1.0 0.8587386909577311 5 Q9H3H5 1 +Large intestinal polyposis 0.5162393944574319 0.9134615073703704 0.3609998693637182 1.0 0.8587386909577311 8 Q15437 1 +Abnormal facial expression 0.3498973922087101 0.9132804381315104 0.3610950679292226 1.0 0.8587386909577311 32 P35270,Q9NR77,P12235,P04062 4 +Type i transferrin isoform profile 0.4740740026852598 0.91232702956803 0.3615965896096089 1.0 0.8594799778227346 10 Q9H3H5,Q9H0U3,Q9BT22,P51571 4 +Abnormal lower motor neuron morphology 0.4734941011356727 0.908954817357078 0.3633739762255032 1.0 0.8614436462560622 10 Q13510,P35637,Q99720 3 +Abnormality of peripheral nerves 0.3427632261406554 0.9065595257262022 0.364639773340343 1.0 0.8620340246111073 42 O15269,O43681,Q71SY5,Q9NR77,Q9NZJ7,O95831,O15121,P07602,Q9Y619 9 +Severe global developmental delay 0.2995996196061617 0.9061110338611196 0.3648770857291497 1.0 0.8620340246111073 65 Q9HC21,Q9Y5Y5,Q71SY5,P00846,Q9H490,O15121,Q15067,P40855,Q96A33,Q9BV10,O75381,Q9BT22,Q7LGA3,P03886 14 +Atrophic scars 0.5148089781168566 0.9059625794780176 0.3649556592710894 1.0 0.8620340246111073 8 Q9NWM8 1 +Abnormal pulmonary thoracic imaging finding 0.3936509912526268 0.903592627836923 0.3662114518361568 1.0 0.8631262446496114 18 P21964,Q13510,Q9NZ08,P04062 4 +Coloboma 0.3464927773486889 0.9008388915472522 0.3676739858985867 1.0 0.8631262446496114 37 O95202,O43924,Q10713,Q9UHX1,P53701,O43505,Q8IY17 7 +Thyroid carcinoma 0.4356585907772732 0.9005906540467478 0.3678060055844936 1.0 0.8631262446496114 13 Q15437,P21912 2 +Dental crowding 0.3682661921322903 0.8967547080302744 0.3698498209118988 1.0 0.8641081010533564 23 Q01105,O75844,Q96A33,Q9UBM7,P51812 5 +Polydactyly 0.3427819828480385 0.89583304806742 0.3703419365049716 1.0 0.8641081010533564 41 Q9UBM7,O95202,O95155,Q15067,Q9BRT2,O43924,Q10713,Q9UHX1,Q14739,Q8IY17,P21964 11 +Prominent sternum 0.7468878588694128 0.8950213128111087 0.370775695024292 1.0 0.8641081010533564 3 P16278 1 +Frontotemporal dementia 0.4424156210822459 0.894724371820229 0.3709344470471052 1.0 0.8641081010533564 12 P35637,Q9UHD9,P05067,O96008,P22626 5 +Abnormal circulating amino acid concentration 0.3366515160104661 0.8936158616821103 0.3715274567214233 1.0 0.8641081010533564 46 Q9UJS0,P00846,Q6PGP7,Q8IUX1,P09622,Q9P0J0,O75880,Q5XKP0,Q9HCC0,P51649,P35270,Q99797,O75208,O96000,Q9Y619,P22695,P03886 17 +Cholestasis 0.3020607864463665 0.8933625595243291 0.3716630459907659 1.0 0.8641081010533564 69 O75381,Q9Y5Y5,Q9UJS0,Q6PGP7,Q9UBM7,O15118,Q15904,Q9NSD9,P35670,Q9H3H5,Q13043,P40855,Q14739,Q13510,P00374,Q00059,Q15437 17 +Dermatological manifestations of systemic disorders 0.3027539918193255 0.8913469571267097 0.3727430645364029 1.0 0.8641081010533564 70 Q9UJS0,Q6PGP7,P35670,Q9H3H5,Q15437,O75787,O43772,Q00325,P04066,O75381,Q14739,Q00059,P50542,O75844,Q9Y5Y5,P51812,O15118,Q16625,Q15904,P00374,Q13043,O75648,P28288,P40855,P53007 25 +Reduced tendon reflexes 0.3688779423012948 0.8909069582011833 0.3729790870750673 1.0 0.8641081010533564 160 O15269,Q9HC21,P35610,O14979,P54802,Q8N2K0,P41440,Q9H3H5,Q10713,P05023,O43681,Q71SY5,P00846,P04062,Q9NZJ7,O95831,P07602,Q99720,O75381,Q9BT22,Q9BQT8,Q96AY3,P40939,P51649,P10253,Q9H6K4,O43505,Q8TAA9,Q13510,O43819,Q9Y5Y5,P03886,P50402,Q15041,Q9NWS8,Q9NR77,Q16637,O60313,P35637,Q15067,P12235,P40855,Q8IY17,P53007,O75477 45 +Joint subluxation 0.5275689508771284 0.8908392241470595 0.3730154289364726 1.0 0.8641081010533564 6 Q9UHX1 1 +Sensory ataxia 0.5644599296677242 0.8907181850707424 0.3730803764029557 1.0 0.8641081010533564 5 Q9NR77 1 +Abnormal odontoid tissue morphology 0.3430658863454253 0.888986748459307 0.3740102016565909 1.0 0.8641081010533564 40 Q96L58,Q13586,P48651,Q96AY3,Q9Y4P3,Q9HC07,P53701,Q9UBM7,P51648,Q6P4Q7,P21964,P16278 12 +Oligosacchariduria 0.5639972736087303 0.8885598586625416 0.3742396724009733 1.0 0.8641081010533564 5 P16278,P10253 2 +Osteolysis 0.3653111223488878 0.8873197904817987 0.3749067535554051 1.0 0.8641081010533564 24 O75844,P04062 2 +Abnormal femoral head morphology 0.4007118206632845 0.8872558139169556 0.3749411889747684 1.0 0.8641081010533564 17 Q96L58,Q96DX4,O95831,Q6NUQ1,P38646,Q7LGA3,P16278,P50542 8 +Dysplasia of the femoral head 0.7448670481319376 0.8872215666134128 0.3749596234070131 1.0 0.8641081010533564 3 Q96L58,P38646 2 +Mortality aging 0.3280087571219846 0.8863454062787223 0.3754314281732973 1.0 0.8641081010533564 102 Q9HC21,Q9Y4P3,O43464,O96000,P16278,P04062,Q9NZJ7,P49411,P16435,P07602,Q6PJG6,Q9H936,Q5JTZ9,Q14739,O75381,Q9BT22,Q00059,P50542,Q5T160,Q8TCJ2,Q6NUQ1,O75844,P20674,Q9NVI7,O60508,O43819,P05067,Q9Y5Y5,P51812,Q12768,Q9NWS8,P51114,Q15904,Q15067,Q6NUK1,O75718,P40855 37 +Abnormality of the temporomandibular joint 0.6140532684744409 0.8861611079612625 0.375530717885695 1.0 0.8641081010533564 4 Q96RL7,O75844 2 +Abnormal atrioventricular conduction 0.4410241252622887 0.8859138642656608 0.3756639445479979 1.0 0.8641081010533564 12 P50402,P06280,Q9BTV4,P21912 4 +Specific learning disability 0.3199660695598625 0.8849216017418987 0.3761989163669734 1.0 0.8641081010533564 55 P48651,Q9UJX6,P00403,Q10713,P22626,Q13586,Q6PI48,P00367,Q9Y4W2,Q9H6K4,O43505,Q9Y619,P03886,Q5THJ4,P35637,Q9NSD9,P09651,P53701,P21964 19 +Prenatal maternal abnormality 0.4250402030965687 0.8848000146104392 0.3762645015931207 1.0 0.8641081010533564 14 P50416,O43772,P16435,P40939,Q14739,Q8TAA9 6 +Abnormal atrioventricular valve morphology 0.350200964293864 0.8843345591536131 0.3765156377892771 1.0 0.8641081010533564 30 P04062,Q9Y4P3,O75844,P55795,P53701,P21964 6 +Abnormal sternal ossification 0.6133536470759474 0.8831393736833973 0.3771609729293967 1.0 0.8649183339545314 4 Q9Y619 1 +Abnormal circulating igm level 0.4324836553608726 0.879854514855608 0.3789381279665735 1.0 0.8669328887609381 13 P49327,Q15904,Q9BV10 3 +Type ii transferrin isoform profile 0.7428112032784071 0.8792975221052409 0.379239979076595 1.0 0.8669328887609381 3 Q15904 1 +Inflammation of the large intestine 0.4678280638020852 0.8760299187463026 0.381013769147891 1.0 0.8691336759202268 10 P08183,Q13043,P49327,Q6PGP7 4 +Skeletal muscle hypertrophy 0.3397883076830508 0.8746004044077105 0.3817913676708127 1.0 0.8702085599997081 42 Q9NR77,Q96A33,Q10713,P10253,P21912,Q7LGA3,P16278,Q15437 8 +Abnormality of upper limb joint 0.323867721338538 0.8717714727022933 0.3833330602305123 1.0 0.8722747949331193 98 Q03164,Q9Y4P3,Q7LGA3,P16278,Q8IZA0,Q96DX4,Q71SY5,O95831,Q15392,P42892,P37268,P23786,Q96AY3,O75844,Q9BV10,Q9H6K4,Q13510,Q9Y619,P50402,O95202,Q9NR77 21 +Increased intramyocellular lipid droplets 0.5234989474652262 0.870644608658499 0.3839482315398559 1.0 0.8722747949331193 6 O00483,Q8NI60 2 +Small epiphyses 0.6102061657470671 0.8695599593091862 0.3845409275733669 1.0 0.8722747949331193 4 Q96DX4 1 +Abnormal blood transition element cation concentration 0.4384221888401695 0.8694472750096837 0.3846025348799045 1.0 0.8722747949331193 12 O43819,Q9Y487,Q15904,Q6PGP7 4 +Red green dyschromatopsia 0.7402384581186585 0.8693970848115747 0.3846299770513683 1.0 0.8722747949331193 3 Q9H6K4 1 +Myalgia 0.3420152261326066 0.8691837878010029 0.3847466134422967 1.0 0.8722747949331193 39 Q13586,Q9NZ08,Q8IUX1,P23786,O60313,P40939,P49327,P06280,P12235,Q14739,P21964 11 +Biliary cirrhosis 0.5155108187201695 0.8688002473884301 0.3849563977876284 1.0 0.8722747949331193 7 Q14739,P09601 2 +Short palpebral fissure 0.3631674635737493 0.8685601732218298 0.3850877462613307 1.0 0.8722747949331193 24 Q03164,O75844,Q6NUK1,Q9UHX1,Q9Y619 5 +Tongue fasciculations 0.4381710044710947 0.8678582323472898 0.3854719466294878 1.0 0.8727084871691605 12 Q9BQT8,Q9NWS8,Q16637,O95831,Q13510 5 +Ureteropelvic junction obstruction 0.7392328398384986 0.866087746900918 0.3864420441315153 1.0 0.8740307571565941 2 Q9UBM7 1 +Pneumothorax 0.5221766630046538 0.8640905759249494 0.3875381356026608 1.0 0.8759468979950383 6 Q96L58,Q8NCH0,Q9H078,Q6NUK1 4 +Polyhydramnios 0.3377126103350153 0.8638393558622064 0.3876761447840231 1.0 0.8759468979950383 43 Q6PGP7,Q9UBM7,P04062,O75844,P51798,Q70HW3,Q9BV10,Q9NVI7,Q14739,P21964 10 +Eyelid myoclonus 0.4646112273988749 0.8573596984536261 0.391246125022942 1.0 0.8760128141551283 10 Q13510,Q01105 2 +Abdominal pain 0.3036130674979337 0.8571197683038373 0.391378697103923 1.0 0.8760128141551283 74 Q9NZ08,P42892,P14174,P04062,P23786,Q14108,Q9Y4P3,P35637,P06280,P49327,Q13043,Q70HW3,Q01844,P21912,Q14566,Q13423 16 +Retinal pigment epithelial mottling 0.7369230205293222 0.8566656098661504 0.3916297144949316 1.0 0.8760128141551283 3 P00846 1 +Renal cell carcinoma 0.3965849627493381 0.8566627358738369 0.3916313032869776 1.0 0.8760128141551283 17 Q8WU17,Q15437 2 +Gingival bleeding 0.4643594825981777 0.8558993829000272 0.3920534363383587 1.0 0.8760128141551283 10 P04062 1 +Reduced forced expiratory volume in one second 0.7365410497981211 0.855248283295615 0.3924137114661232 1.0 0.8760128141551283 2 Q96J02 1 +Abnormal dermatoglyphics 0.2950693116761897 0.8548060971908287 0.3926585022107802 1.0 0.8760128141551283 64 Q9Y5Y5,Q71SY5,Q9UBM7,O95202,Q8NCH0,Q9Y487,Q9Y4P3,Q6NUK1,Q9H3H5,Q9UHX1,O75381,P51812,P40855,Q8IY17 14 +Abnormality of somatosensory evoked potentials 0.7362045760430791 0.8538953179955873 0.3931629939996464 1.0 0.8760128141551283 2 Q9NQZ5 1 +Abnormal blood ion concentration 0.3031988130612921 0.8533034161478261 0.393491066140917 1.0 0.8760128141551283 61 Q6PGP7,Q9Y487,Q15043,Q9Y4P3,Q15904,Q9NSD9,P35670,P40939,P51798,Q9BV10,P21912,P21964,P05023,O43819,Q13423 15 +Steroid resistant nephrotic syndrome 0.5561290059346131 0.8519277816553694 0.3942541762249765 1.0 0.8760128141551283 5 Q92621,Q8N1F7 2 +Abnormality of the umbilical cord 0.5115649432745767 0.848723880507654 0.3960349548444979 1.0 0.8760128141551283 7 Q12768,O75844,P16435 3 +Aplasia hypoplasia of the palmar creases 0.7348586810228934 0.84848789884914 0.3961663089474658 1.0 0.8760128141551283 2 Q8NCH0 1 +Increased susceptibility to fractures 0.3311782590449325 0.8480879438700786 0.3963889953322017 1.0 0.8760128141551283 47 O15269,P04062,Q96AY3,Q14108,P16435,P35670,Q14739,Q13126,O75718,P22626 10 +Polymicrogyria 0.3026009874230952 0.8430971827731537 0.399174094227132 1.0 0.8803669386750806 74 Q9Y5Y5,Q96N66,Q01105,P37268,P23786,Q9Y320,Q9Y487,Q6ZXV5,Q9NZ01,Q10713,O75381,P40855,Q15392,O43505 14 +Hyperthyroidism 0.5027333724126076 0.8427760043140993 0.3993537305738992 1.0 0.8803669386750806 8 P12235 1 +Renal cyst 0.3073125042302775 0.8408557110561132 0.4004287723758686 1.0 0.8818781523919907 59 Q9Y5Y5,Q9NWS8,Q6PGP7,Q8N6S5,P23786,Q9Y4P3,Q10713,Q9UHX1,O75381,P40855,P21964,O43505 12 +Arm dystonia 0.5534012971852035 0.83926373159821 0.4013213307454202 1.0 0.8821930715058753 5 Q99720 1 +Recurrent pancreatitis 0.7323768016907959 0.8392593598079194 0.4013237834744123 1.0 0.8821930715058753 3 P03886 1 +Progressive inability to walk 0.3757421809890999 0.838628685579678 0.4016777083081537 1.0 0.8824826119453275 19 P00846,P21912 2 +Abnormality of bone mineral density 0.3448297758401933 0.8365036755408498 0.402871609866118 1.0 0.8841263881068725 130 Q9HC21,P17050,O43292,P54802,Q9Y4P3,P35670,Q9H3H5,Q13126,P16278,Q96DX4,P04062,Q9H490,Q9NZJ7,Q9HC07,P07602,Q14739,Q15392,Q96AY3,Q9Y487,O75844,P06280,Q13510,Q8N6S5,O95202,Q14108,Q9NWM8,Q15043,Q9NSD9,Q13043,P12235,O75718 31 +Abnormality of the anterior fontanelle 0.3448571757980819 0.8327848201008023 0.404966097392279 1.0 0.8866425835443971 30 Q9Y5Y5,Q9Y487,P16435,Q15436,Q6NUK1,O75381,O75718,P51812,P40855,Q9Y619 10 +Abnormality of the posterior pituitary 0.5083870668357177 0.8325782773136002 0.4050826143659241 1.0 0.8866425835443971 7 Q9UHX1 1 +Abnormal csf carboxylic acid concentration 0.5157005038292265 0.8320452435642048 0.4053834072551598 1.0 0.8866425835443971 6 P51649,P36776 2 +Preaxial hand polydactyly 0.5000875180310385 0.8289659420720674 0.4071236794554194 1.0 0.8866425835443971 8 Q9UHX1 1 +Abnormality of the ureter 0.3037352362039148 0.8264092525106391 0.4085719765718532 1.0 0.8871469067602507 60 P23786,P16435,Q9Y4P3,O75844,Q86XL3,Q15058,O76024,Q9UHX1,P21912,P21964,Q8TAA9,Q7LGA3 12 +Gastroesophageal reflux 0.3303210748538606 0.825529738737059 0.4090709061989834 1.0 0.8871469067602507 111 O15269,Q03164,Q9Y4P3,P55795,Q6ZXV5,Q96A33,Q9UHX1,Q8IZA0,Q01105,P00846,Q9NZJ7,Q8NBU5,P16435,Q15436,P07602,Q14739,Q9UBM7,Q9BV10,Q9Y619,Q96J02,O95202,Q9NSD9,Q6NUK1,P51571,P12235,P21964,P53007 27 +Generalized amyotrophy 0.3561802012452562 0.824281931490985 0.4097793827025597 1.0 0.8876331933682895 25 Q6PI48,P17050,Q96DA6,Q13501,Q03252,P35637,Q9Y2U8,Q13043,P09651,P13473,Q99567,P02545,O43819,Q8IY17,P22626 15 +Muscle fibrillation 0.3921826846715457 0.8240642546908488 0.4099030493226796 1.0 0.8876331933682895 17 Q9BQT8,Q9NWS8,Q16637,O95831,Q13510 5 +Neoplasm of the thyroid gland 0.3638963350702568 0.822724018240414 0.4106649536584508 1.0 0.8888579876507959 20 P42892,Q15437,P21912 3 +Type i diabetes mellitus 0.4376772323320373 0.822308178546611 0.4109015231773392 1.0 0.888945101264688 11 Q13043,P00403,P03886 3 +Calvarial hyperostosis 0.5491459087281418 0.8195470908305389 0.4124743462737406 1.0 0.8902333056349403 5 P09651,Q15043,P22626 3 +Central sleep apnea 0.5127816300978691 0.8176344020944191 0.4135659775480043 1.0 0.8916340099724929 6 Q96A33 1 +Pain 0.3655350076403847 0.8122366681724884 0.4166558428482301 1.0 0.895155844183941 164 O15269,Q15800,Q9Y4P3,P35670,Q92804,Q70HW3,Q13423,P22626,P00846,P04062,Q9NZJ7,Q15165,P07602,Q14739,Q14566,O75569,P42892,P14174,P23786,O75844,P06280,P49327,P40939,Q9H6K4,P21912,Q8TAA9,Q13510,P28070,P50402,Q9NZ08,Q8IUX1,Q9NR77,Q14108,O60313,Q15043,Q13043,P12235,P21964,O75477 39 +Myopathy 0.3146496000142544 0.8094937244672313 0.4182312110838959 1.0 0.897053059415749 92 Q53H12,O14979,Q86Y39,Q9Y4P3,Q9H3H5,P00403,P13473,Q13126,P22626,Q13586,P00846,O43676,Q00325,O95155,P23786,Q8NCH0,Q9BTV4,P40939,O76024,P21912,Q07021,P03886,P42167,P50402,Q9NWS8,O60313,Q9NWM8,O75648,P12235,P53007 30 +Abnormality of ocular smooth pursuit 0.3622890392782087 0.8094650933815821 0.4182476733890126 1.0 0.897053059415749 20 O14773,P46977,Q9NW15,P54136,P41440,Q10713 6 +Shuffling gait 0.4561464638861084 0.8083307953386086 0.4189001791451832 1.0 0.897053059415749 10 P04062 1 +Abnormality of the antitragus 0.7240748245927928 0.8076369203568576 0.4192996263030673 1.0 0.897053059415749 3 Q8IY17 1 +Melanocytic nevus 0.4559951124632005 0.8074556724325023 0.4194040032648278 1.0 0.897053059415749 10 Q15437,P21912 2 +Absent septum pellucidum 0.3391908605689667 0.806339112077942 0.4200473443580514 1.0 0.8980048986087144 31 O95202,P51571,Q9NZ01,P53701,O43505,Q15392,Q96N66 7 +Generalized lipodystrophy 0.7233254796364652 0.8047935935952498 0.4209387991790807 1.0 0.898057451773532 3 O75431,O75844 2 +Osteolysis involving bones of the feet 0.7233254796364652 0.8047935935952498 0.4209387991790807 1.0 0.898057451773532 3 O75431,O75844 2 +Foot acroosteolysis 0.7233254796364652 0.8047935935952498 0.4209387991790807 1.0 0.898057451773532 3 O75431,O75844 2 +Deep palmar crease 0.4347112299138434 0.8041523002089486 0.4213090228478957 1.0 0.8981578415514463 11 P61978,Q9Y487,Q6NUK1,O75431,P98175 5 +Abnormal retinal morphology 0.383026957764755 0.8015292125822738 0.422825339308835 1.0 0.8984537310631013 195 Q9NQT5,O75503,Q9Y4P3,Q8N2K0,Q9H3H5,P00403,Q10713,Q9UHX1,P50897,Q86YV9,Q7LGA3,P16278,Q16836,P00846,P04062,Q9NZJ7,P07602,O43924,P17900,Q13432,P38435,O75381,Q6P4Q7,Q9UG56,Q96CU9,O14773,Q8NCH0,Q9Y487,Q9P0J0,P06865,P40939,O76024,P49327,Q9BV10,P21912,O43505,Q13510,P51648,O43819,Q9Y619,Q9Y5Y5,P03886,P51812,Q9NZ08,P10619,Q8N6S5,O95202,O60313,Q9NW15,Q15067,Q5XKP0,P04439,P53701,Q96S66,P21964,P40855,Q8IY17 57 +Aplasia involving bones of the extremities 0.7230820995962313 0.8014910991733962 0.4228473948868612 1.0 0.8984537310631013 2 Q9BXW9 1 +Aplasia of the phalanges of the hand 0.7230820995962313 0.8014910991733962 0.4228473948868612 1.0 0.8984537310631013 2 Q9BXW9 1 +Abnormal circulating proline concentration 0.7222191733479799 0.800599246126718 0.4233636873140414 1.0 0.8984537310631013 3 O96000 1 +Delayed ability to stand 0.7217420916684906 0.7987917590342165 0.4244111698324526 1.0 0.8984537310631013 3 P21912 1 +Ichthyosis 0.3380775246935114 0.7981868256147816 0.4247620814775135 1.0 0.8984537310631013 33 P50402,O75381,P04062,O95470,Q15800,Q9Y5Y5,P51648 7 +Overlapping toe 0.3608641153701558 0.7977169353834985 0.425034773806388 1.0 0.8984537310631013 20 Q96A33,Q96DX4,Q9UHX1,Q71SY5 4 +Horizontal eyebrow 0.5441771131956266 0.7965916377015072 0.4256882355794755 1.0 0.8984537310631013 5 O95155,Q9NZN8,Q16531 3 +Neoplasm of head and neck 0.493635178685269 0.7953527050611933 0.4264083630862643 1.0 0.8984537310631013 8 Q96DX4 1 +Elevated lactate pyruvate ratio 0.5925125586101531 0.7937337760140474 0.4273504327776058 1.0 0.8996014689060899 4 O96000,Q96RP9 2 +Neonatal hypoglycemia 0.4736551749435252 0.793343902792527 0.4275774846067046 1.0 0.8996611757895718 9 Q16836,P31751,O43772,Q96DA6,Q9UJX6,P40939,Q9H078 7 +Bilateral cryptorchidism 0.4324238334921377 0.7901667254185496 0.4294304058351028 1.0 0.9014283552852058 11 O43924 1 +Abnormality of the phalanges of the toes 0.4184521813245755 0.7884473276011322 0.4304350967363328 1.0 0.9025177111128072 13 Q9BXW9,Q71SY5,O75844,Q9H936,O75431,Q7LGA3 6 +Increased circulating antibody level 0.4104421852660643 0.7865381589918449 0.4315522727038368 1.0 0.9026582994215284 14 P28070,Q14108,P49327,P04062 4 +Benign neoplasm of the central nervous system 0.3594989747940278 0.7864678160203435 0.4315934669274754 1.0 0.9026582994215284 20 O43924,Q15437 2 +Abnormal clavicle morphology 0.386905285967745 0.785051577764714 0.4324233285644689 1.0 0.902837814095578 17 Q14739,Q9Y619,O75844 3 +Keratoconjunctivitis 0.4721317714205359 0.7850092408496587 0.4324481505972506 1.0 0.902837814095578 9 Q14739,Q9NZ08,P49327 3 +Multiple prenatal fractures 0.5416530647114779 0.7849602765652725 0.4324768592697237 1.0 0.902837814095578 5 Q14739,O75718 2 +Focal motor seizure 0.3567589459164736 0.7845905881087611 0.4326936501160838 1.0 0.9028741233758651 22 Q9H3H5,Q01105,P21912 3 +Genu valgum 0.3368028988169326 0.7837767799941773 0.4331711009639933 1.0 0.9034540512044964 32 Q96DX4,Q9NR77,Q9Y4P3,Q9NX62,Q9Y619,Q7LGA3,P16278 7 +Episodic pain 0.4308647606860842 0.7806430904976575 0.435012440582748 1.0 0.9060424705421724 11 Q13423,P23786 2 +Aganglionic megacolon 0.409143400279513 0.7778228412329824 0.4366734604347648 1.0 0.9075275455486403 14 P21964,P42892,Q10713 3 +Hyperinsulinemic hypoglycemia 0.5394908955688622 0.7750132950179803 0.4383318035647456 1.0 0.9075275455486403 5 Q16836,P40939,P53985 3 +Abnormal lower limb bone morphology 0.350399480138795 0.7734903499739495 0.439232237623484 1.0 0.9075275455486403 145 P13073,Q03164,Q15058,Q96A33,Q10713,Q9UHX1,Q7LGA3,P16278,Q96DX4,Q71SY5,P04062,Q9NZJ7,O95831,P16435,Q9NX62,P07602,O43924,Q14739,Q9UBM7,O00116,Q15392,Q96AY3,Q9Y487,O75844,P06280,P40939,P51798,Q9BV10,O43505,Q13510,Q9Y619,Q8N6S5,O95202,P21964,O75718 35 +Abnormality of the peripheral nervous system 0.3126164976118745 0.7708842198083283 0.4407755613543636 1.0 0.908047085634481 93 O15269,Q10713,Q9NQZ5,O43681,Q71SY5,P04062,Q9NZJ7,O95831,P07602,Q6PJG6,Q99720,P42892,P06280,O76024,Q9Y619,Q9NR77,O60313,O15121,Q15067,P21964 20 +Abnormality of the brainstem white matter 0.5868031136057154 0.7694781708897177 0.4416094984224048 1.0 0.908047085634481 4 Q10713 1 +Bilateral single transverse palmar creases 0.4224437483973119 0.7686498833799744 0.4421011838931035 1.0 0.9082732126442706 12 Q9Y5Y5,O75381,P40855 3 +Middle age onset 0.4222102906890697 0.7671824847150366 0.442973025247344 1.0 0.9087354636451768 12 P07602 1 +Hemiplegia hemiparesis 0.3337513965434768 0.7647831234143616 0.4444006988916262 1.0 0.910227831688879 36 Q9NZ08,P01889,P17050,O60313,P49327,P00403,Q8IY17,P03886 8 +Generalized joint laxity 0.4216438958205358 0.7636231844883649 0.4450918289519467 1.0 0.910227831688879 12 Q8NCH0,Q9UHX1 2 +Chorioretinal coloboma 0.5016039254308438 0.762667069794245 0.4456619742673795 1.0 0.910227831688879 6 Q10713 1 +Stage 5 chronic kidney disease 0.3470026523110776 0.7604863295975814 0.4469639376094472 1.0 0.9118110448880162 26 O95470,Q8IUX1 2 +Aplasia hypoplasia of the sternum 0.7115449343655121 0.7603503919947265 0.4470451677675344 1.0 0.9118110448880162 3 O60566,Q9Y619 2 +Loss of ability to walk 0.4210176221666246 0.7596888966614908 0.447440567264485 1.0 0.9122066134955372 12 P00846 1 +Spinal cord lesion 0.5005464249151748 0.7574867321796491 0.4487583117573579 1.0 0.9132483755673332 6 O00400 1 +Short nail 0.53547414315235 0.7565775421609311 0.4493030001737454 1.0 0.9139460848098472 5 Q96L58,Q9Y487,O75844 3 +Short sternum 0.7113055181695824 0.755116750245388 0.4501789336350053 1.0 0.9149671296980576 2 O60566 1 +Limited hip movement 0.4129980791740369 0.7530634201366517 0.4514118045929702 1.0 0.9155519215711078 13 Q7LGA3,O75844 2 +Bradykinesia 0.3455830985152075 0.7477145021220745 0.4546323818961681 1.0 0.91592553499806 26 O75787,P04062,Q96RL7,Q15043,O43464,Q6DKK2,P35270,P12235,O75569 9 +Malrotation of small bowel 0.5815869273842063 0.7474219542143148 0.45480889726681 1.0 0.91592553499806 4 Q8NCH0 1 +Bronchitis 0.5813415238423457 0.7463868569965547 0.4554337563538324 1.0 0.91592553499806 4 Q03518 1 +Tachypnea 0.3632851069990977 0.7398509145611358 0.459390461168482 1.0 0.91592553499806 19 P35610,O43924,Q10713,Q9Y619,P22695 5 +Cholangitis 0.7069313593539777 0.7380658366810021 0.4604744427278739 1.0 0.91592553499806 2 Q96J02 1 +Pili torti 0.7069313593539703 0.7380658366809736 0.4604744427278913 1.0 0.91592553499806 2 P02545 1 +Spastic diplegia 0.3512206510757665 0.7377158203858928 0.4606871563828572 1.0 0.91592553499806 22 Q9NZJ7,P51648,P07602,Q99720 4 +Lower limb muscle weakness 0.3300384405082882 0.737329702228086 0.4609218737655878 1.0 0.91592553499806 38 O00400,P00846,Q9NR77,Q13510,O43819 5 +Verrucae 0.7053282896334152 0.737105767082466 0.4610580323316784 1.0 0.91592553499806 3 P16615 1 +Hypercholesterolemia 0.4173290928817309 0.7365465160973513 0.4613981700609897 1.0 0.91592553499806 12 Q8N511,Q9UJS0 2 +Abnormal response to endocrine stimulation test 0.7043823353010275 0.733582207115171 0.4632034083844036 1.0 0.91592553499806 3 Q13423 1 +Developmental cataract 0.3076853084483674 0.7332861093345123 0.4633839453501671 1.0 0.91592553499806 55 O00400,Q15800,Q9H3H5,O76024,P00403,Q99797,P21912,P03886 8 +Aplasia hypoplasia involving bones of the lower limbs 0.2970825611863621 0.7326237550515841 0.4637879384329353 1.0 0.91592553499806 77 Q8N6S5,P13073,Q96DX4,O95202,Q96AY3,Q03164,O95831,Q9NX62,Q96A33,Q7LGA3,Q9UHX1,Q9BV10,Q9UBM7,Q13510,Q9Y619 15 +Psychosis 0.3342079301845672 0.7301746492774384 0.4652834361947171 1.0 0.91592553499806 30 Q5JRX3,Q9UJS0,O15118,O76024,Q6DKK2,P00403,P51649,P51812,P03886 9 +Abnormal palmar dermatoglyphics 0.3112449808730109 0.7300733446739881 0.4653453535165091 1.0 0.91592553499806 53 Q9Y5Y5,Q71SY5,O95202,Q8NCH0,Q9Y487,Q6NUK1,Q9H3H5,Q9UHX1,O75381,P51812,P40855,Q8IY17 12 +Abnormal metacarpal morphology 0.3391605431742581 0.729238996893221 0.4658554806054955 1.0 0.91592553499806 28 Q96L58,Q32P28,Q96DX4,P16435,Q9NX62,O43924,P36776,Q14739,P51812,P16278 10 +Aplasia hypoplasia involving the skeletal musculature 0.4618697308116622 0.729047906043258 0.4659723588244924 1.0 0.91592553499806 9 O43505,Q9NR77 2 +Blue nevus 0.7045760430686513 0.7289259479162452 0.4660469614306601 1.0 0.91592553499806 2 Q8N6S5 1 +Fibroadenoma of the breast 0.7045760430686517 0.7289259479162452 0.4660469614306601 1.0 0.91592553499806 2 P49327 1 +Congenital craniofacial dysostosis 0.704576043068651 0.728925947916243 0.4660469614306615 1.0 0.91592553499806 2 Q6NUK1 1 +Absent hypoplastic paranasal sinuses 0.7045760430686419 0.7289259479162085 0.4660469614306826 1.0 0.91592553499806 2 P04066 1 +Mild postnatal growth retardation 0.7045760430686407 0.7289259479162041 0.4660469614306852 1.0 0.91592553499806 2 Q9Y3E5 1 +Abnormal thyroid stimulating hormone level 0.7045760430686407 0.7289259479162041 0.4660469614306852 1.0 0.91592553499806 2 O14654 1 +Abnormal rib cage morphology 0.2893081762206409 0.7276314348787444 0.4668392324734325 1.0 0.91592553499806 68 Q96L58,P48651,Q03164,P54802,Q9UHX1,P16278,O95831,P16435,Q96HY6,P04066,Q9UBM7,O95155,Q14739,Q32P28,O75844,P51798,Q9BV10,Q8TAA9,Q9Y619,Q9UM00,O95202,O75718 22 +Diarrhea 0.2858665817303998 0.7263828015641358 0.4676041314938028 1.0 0.91592553499806 64 Q16836,Q13510,P42892,P35610,Q9UJS0,Q6PGP7,Q15904,P54802,Q9BT22,P40939,P06280,P00403,Q96A33,Q14566,Q13423,Q96J02,P03886 17 +Low frustration tolerance 0.4613108901136775 0.7260105983885862 0.4678322733694653 1.0 0.91592553499806 9 Q9UHX1 1 +Ovarian cyst 0.3868528422494307 0.7259088683576967 0.4678946395050039 1.0 0.91592553499806 16 Q9Y4P3,Q15437,P21912 3 +Narrow mouth 0.3007135142506353 0.7254590846135238 0.4681704370117532 1.0 0.91592553499806 58 Q6PGP7,P04062,Q8NCH0,Q9Y487,Q9NX62,O75844,Q9Y619,Q6NUK1,Q9NVI7,P21964,Q7LGA3,Q15392 12 +Hepatitis 0.3942739778945744 0.7253468031033661 0.4682392996061058 1.0 0.91592553499806 15 P35670,Q13043,P49327,Q9Y619 4 +Cerebellar atrophy 0.3351197098973421 0.7241927315438352 0.4689474202416286 1.0 0.91592553499806 128 Q9NQT5,O00400,Q5JRX3,P13073,O75503,O43292,Q8N2K0,P41440,Q10713,Q9H9P8,P46977,Q9H490,P51970,Q6PJG6,Q9H936,Q8IV08,Q5JTZ9,Q92643,P51572,Q9BT22,Q96CU9,O14773,Q9Y320,Q6DKK2,P51649,P51798,Q9H6K4,Q9NVI7,Q9Y5Y5,O75208,Q14108,O15121,Q15043,O60313,Q9NW15,Q5XKP0,O75648,P12235,P17480,Q8IY17 40 +Glucose intolerance 0.3121054068051363 0.7214303487833101 0.4706447798303854 1.0 0.91592553499806 97 Q86Y39,Q9Y4P3,P00403,O96000,P00846,Q9Y6M9,O43676,Q969M3,Q96CU9,O75844,O76024,Q8TAA9,P03886,Q8IUX1,O60313,Q06136,Q13043,P12235,Q8IY17 19 +Truncal titubation 0.7018842530282727 0.7185168843318598 0.4724386410076222 1.0 0.91592553499806 2 Q6PJG6 1 +Epiphyseal dysplasia 0.4922826299711116 0.717142065265366 0.4732864424372307 1.0 0.91592553499806 6 P38646,Q9HC07 2 +Arthrogryposis multiplex congenita 0.3298312162003887 0.7161269763200737 0.4739129479832871 1.0 0.91592553499806 33 P04062,Q8NCH0,Q96AY3,O75844,Q96AA3,Q15392 6 +Flaring of rib cage 0.6994278020868224 0.7151876466650746 0.47449310130916 1.0 0.91592553499806 3 Q96L58,P16278 2 +Gastrostomy tube feeding in infancy 0.3326125526967318 0.7148309512716368 0.4747135073915287 1.0 0.91592553499806 30 Q01105,P37268,Q9H490,O15121,Q9BV10,Q99720,Q96J02 7 +Somatic sensory dysfunction 0.3123217844184877 0.7138806018381743 0.4753010132881907 1.0 0.91592553499806 98 O15269,O00400,P17050,P54802,Q71SY5,P00846,Q9NZJ7,P07602,Q8IV08,O14773,Q8NCH0,P06280,P49327,Q9H6K4,O43819,O75298,Q9Y619,Q9NZ08,Q9NR77 19 +Prominent nasolabial fold 0.5259717400052785 0.7132081831626296 0.4757169433035 1.0 0.91592553499806 5 Q8NCH0 1 +Abnormality of the nasolabial region 0.5259717400052785 0.7132081831626296 0.4757169433035 1.0 0.91592553499806 5 Q8NCH0 1 +Ecchymosis 0.4197513600802628 0.7130011601459838 0.4758450392402089 1.0 0.91592553499806 11 Q8NCH0,P04062 2 +Insulin resistant diabetes mellitus 0.4846645888256696 0.7129142363012761 0.475898829192783 1.0 0.91592553499806 7 P31751,A5YKK6,O75844,P02545,O75431 5 +Irregular menstruation 0.5257662512630503 0.7122744007818451 0.4762948728497265 1.0 0.91592553499806 5 P02545,O75616,Q06787,P10644 4 +Renal insufficiency 0.2931019386735095 0.7114422146649917 0.4768102472472035 1.0 0.91592553499806 74 Q9NZ08,Q9NWS8,Q8IUX1,P23786,O95470,Q14108,P06280,P49327,Q13043,Q10713,Q8TAA9,Q9BT22,Q8IY17 13 +Ketoacidosis 0.4391035055303962 0.7102304955749835 0.4775612128291295 1.0 0.91592553499806 10 Q9HCC0,P53985,P35610 3 +Aplasia hypoplasia of the clavicles 0.4388087707205577 0.7085432305247594 0.4786079759202355 1.0 0.91592553499806 10 O75844 1 +Abnormal head movements 0.4383823697608194 0.7061028645321783 0.4801241704573074 1.0 0.91592553499806 10 Q96RL7,P35637,Q99720 3 +Synostosis of metacarpals metatarsals 0.6981830417227547 0.7042697780214198 0.4812647834914565 1.0 0.91592553499806 2 P16435 1 +Symphalangism affecting the phalanges of the hand 0.6981830417227488 0.7042697780213962 0.4812647834914711 1.0 0.91592553499806 2 P48651 1 +Proximal symphalangism 0.6981830417227488 0.7042697780213962 0.4812647834914711 1.0 0.91592553499806 2 P48651 1 +Decreased muscle mass 0.3758473021173184 0.7036368248515377 0.481658972279422 1.0 0.91592553499806 17 Q8NCH0,Q8TAA9,O95202 3 +Abnormal c peptide level 0.6957253450016707 0.7015100411433637 0.4829847704618588 1.0 0.91592553499806 3 Q16836,P40939 2 +Ovoid vertebral bodies 0.4821068987009063 0.7001256656522127 0.4838488287096147 1.0 0.91592553499806 7 Q96L58,P54802,P16278 3 +Developmental stagnation 0.4817321439437057 0.6982540855219952 0.4850183077618777 1.0 0.91592553499806 7 P54136 1 +Ectrodactyly 0.4044296012069731 0.6977073078418816 0.4853602570341626 1.0 0.91592553499806 13 Q99720,O95202,Q9NR77 3 +External ear malformation 0.4110853751300148 0.6974993531716975 0.4854903440484484 1.0 0.91592553499806 12 Q9Y5Y5,Q8NCH0,O75381 3 +Limb girdle muscular dystrophy 0.4744265585870346 0.6959890862779141 0.4864356645354037 1.0 0.91592553499806 8 P50402,P09651,O14979,Q9BTV4 4 +Muscle fiber inclusion bodies 0.4169203843983248 0.695850327717367 0.4865225674851645 1.0 0.91592553499806 11 O43676 1 +Hepatic fibrosis 0.3306063904302397 0.6955519033050911 0.4867094958186375 1.0 0.91592553499806 30 Q9UJS0,P04062,Q15904,Q13043,Q10713,Q13510,Q8IY17 7 +Absent epiphyses 0.5691425476387609 0.6952476741674013 0.4869001000844928 1.0 0.91592553499806 4 P36776,Q7LGA3 2 +Lymphocytosis 0.6958277254374278 0.6952439042978685 0.4869024622190598 1.0 0.91592553499806 2 P49327 1 +Extra axial cerebrospinal fluid accumulation 0.6958277254374163 0.6952439042978253 0.4869024622190869 1.0 0.91592553499806 2 P20700 1 +Acute coronary syndrome 0.366155376299921 0.6933663047079787 0.4880797024705234 1.0 0.91592553499806 18 Q9NZ08,Q9Y4P3,O75844,P06280,P49327 5 +Progressive extrapyramidal movement disorder 0.6933692359474739 0.6928376813789515 0.4884114219232356 1.0 0.91592553499806 3 P54136,Q9BPX6 2 +Chondrosarcoma 0.6915389801215807 0.6861182592331563 0.4926385375910724 1.0 0.91592553499806 3 Q92804 1 +Pancreatic islet cell hyperplasia 0.6912576596665989 0.6850868133414335 0.4932891408871258 1.0 0.91592553499806 3 Q14739 1 +Nonprogressive 0.5196818976916509 0.6847106996734699 0.4935264958838739 1.0 0.91592553499806 5 Q10713 1 +Hypoplasia of teeth 0.3951138771704927 0.6840977042870283 0.4939134714261963 1.0 0.91592553499806 14 O75844 1 +Elevated hemoglobin a1c 0.6906765398855471 0.6829573325235184 0.4946338041926328 1.0 0.91592553499806 3 O75431,Q969M3 2 +Abnormal cd4 cd8 ratio 0.4850676462942921 0.6821383679214842 0.4951514616324837 1.0 0.9162426719541832 6 Q13432 1 +Rod cone dystrophy 0.3208557545042585 0.681161774461619 0.4957691324581921 1.0 0.9166364360027334 43 Q9Y5Y5,P00846,Q15067,Q9H3H5,P38435,O75381,P03886 7 +Rimmed vacuoles 0.3945053823693795 0.6800532696599887 0.4964707319249521 1.0 0.9168313896013908 14 P50402,Q13501,O14979,Q9BTV4,P09651,P02545,P43243,P22626 8 +Purpura 0.3462748348221913 0.6779175855786527 0.4978239492320884 1.0 0.917065436176931 20 Q13586,Q8N6S5,P04062,Q8NCH0,P51798,P38435,P21964 7 +Renal dysplasia 0.4012120670343062 0.6770084062900942 0.4984006207925615 1.0 0.9172310018870988 13 O43505,O43819,Q9NWS8 3 +Abnormal corpus striatum morphology 0.3719769733154369 0.6752802766334249 0.4994977124108413 1.0 0.9173096692056376 17 O43819,P00846 2 +Malar prominence 0.6904441453566645 0.6747356590715153 0.4998437248028153 1.0 0.9173096692056376 2 Q9Y4W2 1 +Large for gestational age 0.4834905660377285 0.6745174580184155 0.4999823903709173 1.0 0.9173096692056376 6 Q9UM00,P31751,P50570,P42345,Q8NCE2 5 +Distal muscle weakness 0.2821092394059155 0.673975547038551 0.5003268600980353 1.0 0.917401808551473 64 O15269,P17050,Q96RL7,Q9H3H5,P41440,O94905,Q96BR5,P39210,P22626,O75340,Q6PI48,Q71SY5,P00846,O95831,O95140,Q99720,P02545,Q9BQT8,Q8TB36,P07196,Q13501,P40939,P36551,Q9Y3E5,Q5THJ4,Q9NR77,P35637,P09651,P43243,Q8IY17,P53007 31 +Temporal pattern 0.4768248175036913 0.6738010235906459 0.500437824011073 1.0 0.917401808551473 7 P04062,Q9NR77 2 +Abnormality of the optic nerve 0.3869089539215895 0.6693249248478804 0.5032882305392374 1.0 0.917402875555684 221 Q9HC21,P17050,O43292,Q86Y39,Q9H061,Q8N2K0,Q6ZXV5,P41440,Q53FT3,Q9H3H5,P00403,Q10713,Q9UHX1,P50897,Q8WWV3,Q15058,O96000,Q7LGA3,P16278,Q9H9P8,P01889,O43681,Q96DA6,P04062,P00846,O43676,Q9H490,Q9NZJ7,Q9Y6M9,Q15436,P07602,O95831,Q6PJG6,P38435,O75381,Q9UBM7,P51572,Q6P4Q7,Q9UG56,Q96CU9,P37268,Q9P0J0,P06280,O76024,P49327,P51798,Q9H6K4,O43505,Q9NVI7,O43819,Q9Y5Y5,P51812,P03886,Q9NZ08,Q8IUX1,O95202,O60313,Q15043,P04439,Q15067,Q5XKP0,Q96S66,P21964,P40855,Q8IY17 65 +Abnormal rectum morphology 0.3326462405135584 0.6688211706785749 0.5036095602266517 1.0 0.917402875555684 28 Q9Y4P3,P53701,P21912,Q8TAA9,Q15437 5 +Abnormality of metacarpal epiphyses 0.5160388776154881 0.6682894357291371 0.5039488554840097 1.0 0.917402875555684 5 P16435,O95202 2 +Redundant neck skin 0.4753862234320928 0.6666526976827676 0.5049939998634936 1.0 0.917402875555684 7 O96000 1 +Protrusio acetabuli 0.6861006737691648 0.6662450154207833 0.5052545042515155 1.0 0.917402875555684 3 Q96AY3 1 +Hypoplasia of the musculature 0.515563005394785 0.6661491950451612 0.5053157426676473 1.0 0.917402875555684 5 Q9NR77 1 +Uveitis 0.4752731973565502 0.6660914774496571 0.5053526316369401 1.0 0.917402875555684 7 Q13043,P49327,P14174 3 +Hiatus hernia 0.468308557660728 0.6646238323729395 0.5062911220111952 1.0 0.917402875555684 8 Q8NCH0,Q8NBU5 2 +Skin rash 0.3781346242791767 0.6641098196826102 0.5066200256958018 1.0 0.917402875555684 16 Q06136,P28070,Q14739,P21912 4 +Abnormality of the pulmonary veins 0.4747683121526251 0.6635852430475995 0.5069558047598666 1.0 0.917402875555684 7 Q15392 1 +Elevated circulating alanine aminotransferase concentration 0.4495082828057201 0.6621574565717439 0.5078703162128755 1.0 0.917402875555684 9 P53597,Q96RL7,Q15904,O75880,P10253 5 +Bifid tongue 0.5605347376840462 0.6595704993238075 0.509529490844667 1.0 0.917402875555684 4 Q9UBM7,P61978 2 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0.650109050715886 0.5156217833742678 1.0 0.921363628697192 14 P16435,P31939,P51809,Q6NUK1,P02545,Q9Y619 6 +Bowing of the legs 0.3146281695303113 0.6478860247831416 0.5170586703150393 1.0 0.9217755510914862 46 Q96L58,Q32P28,Q96DX4,Q9NR77,P16435,Q9Y4P3,Q9NX62,Q9Y619,P36776,P51798,Q13126,O75718,Q7LGA3,P16278 14 +Abnormality of the palm 0.309751617635195 0.6475480399796157 0.5172773134548292 1.0 0.9217755510914862 101 Q9H3H5,P07858,Q9UHX1,Q15437,Q96DX4,Q71SY5,O95831,P16435,O75381,Q14739,Q8NCH0,Q9Y487,P16615,P21912,Q9Y5Y5,P51812,Q9Y619,P42167,O95202,Q6NUK1,Q06136,Q13043,P40855,Q8IY17 24 +Abnormal leukocyte physiology 0.302307546332192 0.6439865483864529 0.5195841568261268 1.0 0.9239877593069672 54 P14174,Q9UJS0,Q6PGP7,P04062,Q14108,Q15904,P09601,Q9H0U3,P49327,Q13043,Q9BV10,P21964,P28070 13 +Abnormality of bladder morphology 0.4272274942293543 0.6425608766073951 0.5205090761059359 1.0 0.9248610454287682 10 Q9NWM8,Q9Y4P3 2 +Abnormal cerebral artery morphology 0.4021277173234882 0.6418131896776375 0.520994484646558 1.0 0.9251227554822016 12 P10253,Q9NSD9,P38435 3 +Head tremor 0.4020035889335759 0.6410446860493544 0.5214936504819163 1.0 0.9251515180190596 12 P22307,P07196,Q96RL7,P35637,Q99720 5 +Abnormal cerebral vascular morphology 0.2847921637969143 0.6400282730608585 0.5221542185416741 1.0 0.9251515180190596 62 P04062,P23786,Q9Y4P3,O75844,Q9NSD9,Q96AA3,Q9H3H5,P06280,P00403,O76024,P10253,P38435,P21912,P03886 14 +Cough 0.3368775694938092 0.6395444682214271 0.5224687949324673 1.0 0.9251515180190596 24 O15269,P35610,Q9NR77,P04062,Q9NSD9,P41440 6 +Wide cranial sutures 0.4698892918808245 0.6394290385017812 0.5225438632688162 1.0 0.9251515180190596 7 O75844 1 +Hypoglycemic coma 0.4451138107045602 0.6385453455633291 0.5231187459342825 1.0 0.9251515180190596 9 Q16836,P40939,Q13423 3 +Aplasia hypoplasia involving the vertebral column 0.3814223594538669 0.6372740905079912 0.523946324567075 1.0 0.9251515180190596 15 O95831,Q96HY6,P36776,P04066,Q14739,Q8TAA9,P16278 7 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0.9300816443835648 17 P05023,Q13423,Q9Y4P3 3 +Aplasia hypoplasia of the tongue 0.5053745821021178 0.6206114771350274 0.5348552863345879 1.0 0.931922673698388 5 Q9UBM7,P48651 2 +Lipodystrophy 0.3200336195479988 0.6190015044346006 0.5359153678011634 1.0 0.933317225155257 33 P50402,P42167,Q9Y487,O75844,Q9H3H5,P28070 6 +Sideroblastic anemia 0.4653086499674551 0.6168604705745634 0.5373267619884396 1.0 0.9340606041060118 7 O76024,P38646,O75027 3 +Abnormal sarcomere morphology 0.6749663526244972 0.6167893962417055 0.5373736470177033 1.0 0.9340606041060118 2 P51114 1 +Abnormal z disc morphology 0.6749663526244972 0.6167893962417055 0.5373736470177033 1.0 0.9340606041060118 2 P51114 1 +Abnormality of endocrine pancreas physiology 0.5497698649100113 0.6154927151503142 0.538229378789203 1.0 0.9342302217856115 4 Q14739 1 +Congenital onset 0.3043400521308156 0.6153292283744609 0.5383373187787139 1.0 0.9342302217856115 97 Q9NQT5,Q9HC21,Q4J6C6,Q9H3H5,Q9UHX1,Q7LGA3,P46977,Q71SY5,Q9NZJ7,Q8NBU5,P07602,O43924,O00483,O75352,Q00059,P50542,P34897,Q5T160,Q8TCJ2,Q9NRZ9,Q96RP9,P20674,O43505,O60508,O43819,P08670,Q9NWS8,Q5XKP0,Q6NUK1,P12235,Q9BW92,P51571,Q96N66 33 +Abnormality of globe size 0.3048736922304703 0.6142230550634015 0.5390679403460878 1.0 0.9342302217856115 51 Q6NUK1,O43924,Q15058,Q9UHX1,P53701,O43505,P21964,O75569 8 +Severe postnatal growth retardation 0.440459524519833 0.6136479495449958 0.5394479907069432 1.0 0.9342302217856115 9 O76024 1 +Increased circulating lactate dehydrogenase concentration 0.3844649805217214 0.6136341433158531 0.5394571160076937 1.0 0.9342302217856115 14 Q5JRX3,Q9UJS0,P23786,P41440,P10253 5 +Hepatosplenomegaly 0.3191474964675457 0.6134864663486652 0.5395547287222593 1.0 0.9342302217856115 35 P10619,Q9UJS0,P04062,Q13043,P51798,Q14739,Q13510,P16278 8 +Akinesia 0.4031813521748952 0.6132050261202954 0.5397407818443374 1.0 0.9342302217856115 11 P04062 1 +Atrial flutter 0.6736204576043091 0.6118263658666792 0.5406526435452412 1.0 0.9344539628825554 2 P02545 1 +Abnormal metatarsal morphology 0.3321038169092054 0.6116657625261785 0.5407589184974528 1.0 0.9344539628825554 25 Q96DX4,O95202,P16435,O43505,Q15392 5 +Broad phalanx of the toes 0.4640126616136176 0.6104958235575962 0.5415334091622883 1.0 0.9344539628825554 7 Q7LGA3,Q71SY5 2 +Aplasia hypoplasia involving the pelvis 0.3834925507785509 0.6072364207694435 0.5436940251838864 1.0 0.9344539628825554 14 Q96L58,Q96DX4,O95202,O95831,Q96HY6,P50542 6 +Vertebral fusion 0.4209741530602665 0.6072285513224932 0.5436992469244526 1.0 0.9344539628825554 10 Q8TAA9,Q9UHX1 2 +Diminished movement 0.3365001585433244 0.6053426794327033 0.544951328823227 1.0 0.9344539628825554 21 P04062,O95831,Q9H3H5,P12235,Q2TAA5 5 +Abnormal sputum 0.4690049681589279 0.6051005687805557 0.5451121763537019 1.0 0.9344539628825554 6 Q9NZ08,P49327 2 +Cerebral calcification 0.3235143983739669 0.604875129410106 0.5452619694153902 1.0 0.9344539628825554 29 P23786,O60313,Q16625,Q9NSD9,P00403,P05067,P03886 7 +Abnormal blood sodium concentration 0.4204956540817992 0.6045346495664266 0.5454882397760055 1.0 0.9344539628825554 10 Q13423 1 +Abnormality of the dorsal column of the spinal cord 0.6681252103668716 0.6016210544140397 0.5474264107679458 1.0 0.9360103924079508 3 Q6PI48,P54886 2 +Soft skin 0.4380591550312124 0.6008554919409077 0.5479362399456065 1.0 0.9360798685479488 9 Q9NWM8 1 +Respiratory insufficiency 0.3539710609229571 0.5992824800173329 0.5489845290298558 1.0 0.9363365088897254 171 Q96L58,Q9NQT5,Q53H12,Q9UMS0,Q86Y39,Q96AA3,O43464,P36776,Q9H3H5,Q92804,Q70HW3,P13473,O96000,Q13586,O43772,Q9NZJ7,O43676,Q8NBU5,P49411,Q9Y6M9,O95831,P07602,Q00325,Q15165,Q9HCC0,Q9UHD9,Q14739,O75381,Q9BT22,Q96CU9,P23786,Q96AY3,Q9BTV4,P06280,O76024,P40939,P10253,Q9Y5Y5,Q13510,O43819,Q9Y619,P03886,Q8N183,P50402,Q8IUX1,Q9NR77,Q16637,P35637,Q15067,Q5XKP0,Q9NSD9,Q6NUK1,O75648,P12235,P53701,O75208,P40855,P53007 58 +Cerebral inclusion bodies 0.3888002447192682 0.5977237969117657 0.5500242442830598 1.0 0.936735919981351 13 O96008,O15118,P04062 3 +Abnormality of acid base homeostasis 0.3501174569952339 0.5970250387637017 0.5504906636796432 1.0 0.936735919981351 165 Q9HC21,Q53H12,Q5JRX3,P13073,P35610,Q9UMS0,Q9UJS0,P09622,Q86Y39,Q9BRT2,O43464,P36776,P00403,Q70HW3,Q10713,Q9UBX3,O96000,Q16836,Q6PI48,Q9H9P8,P01889,Q96DA6,P00846,Q9Y6M9,O43676,P49411,P51970,O95831,Q00325,Q9HCC0,Q5JTZ9,P11177,O14949,Q96CU9,P53985,P23786,Q9P0J0,P40939,P21912,Q3ZCQ8,Q9NVI7,Q07021,O43819,Q9Y619,P03886,Q8N183,Q9NWS8,Q8IUX1,Q9BWD1,Q86VD7,O75880,Q5XKP0,P54136,P08574,O75648,Q99797,P12235,Q9BW92,O75208,Q6P4A7,P22695,Q8NI60,Q4J6C6 63 +Deformed tarsal bones 0.6695827725437458 0.5970142689394015 0.5504978540349768 1.0 0.936735919981351 2 O75787 1 +Achilles tendon contracture 0.4000100977870134 0.5942912661962868 0.5523173191396218 1.0 0.938234288441818 11 P50402,O60313,Q9BTV4,Q8N2K0,Q9Y3E5 5 +Synostosis involving digits 0.6657691013126796 0.593281225104726 0.5529929614847604 1.0 0.9386157136185448 3 Q15233,P48651 2 +Abnormality of the intrinsic pathway 0.3998145731495482 0.5931273932287539 0.553095899113861 1.0 0.9386157136185448 11 Q9H3H5,Q9BV10,P38435 3 +Premature graying of hair 0.4604156252755071 0.5928808472935438 0.553260896565348 1.0 0.9386157136185448 7 Q13126 1 +Truncus arteriosus 0.454042421749306 0.5921763873541371 0.5537324795172958 1.0 0.9390639203199684 8 Q9UHX1 1 +Epistaxis 0.3878599959592919 0.5917594973041933 0.5540116487420006 1.0 0.9390928945652012 13 Q13586,Q86YV9,P38435,P04062 4 +Low back pain 0.6679004037685083 0.5908772972426883 0.5546026385430665 1.0 0.9390928945652012 2 P54886 1 +Neoplasm of the eye 0.3936899485405978 0.5897991554962264 0.5553253089417398 1.0 0.9390928945652012 12 Q15437 1 +Weakness of long finger extensor muscles 0.6672274562584137 0.5884283270265549 0.5562448288128587 1.0 0.9390928945652012 2 Q13501 1 +Abnormal renal pelvis morphology 0.3068054763671366 0.5876258078920197 0.5567834844163584 1.0 0.9390928945652012 48 Q9Y5Y5,Q71SY5,P23786,Q8NCH0,P16435,O76024,O75381,O75718,P40855,O43505 10 +Nonimmune hydrops fetalis 0.3273539865211915 0.5846625067050649 0.5587746692062194 1.0 0.9390928945652012 26 Q14739,Q9BT22,P10619,P04062 4 +Abnormal circulating carboxylic acid concentration 0.2911155323270653 0.5838577832234968 0.5593159982935045 1.0 0.9390928945652012 83 Q9UJS0,Q6PGP7,P09622,P41440,O96000,Q9H9P8,P00846,Q9HCC0,Q14739,P37268,P23786,Q9P0J0,P35270,P51649,Q9Y619,P03886,Q8IUX1,Q9NSD9,Q5XKP0,O75880,Q99797,O75208,P40855,P22695 24 +Abnormality of the septum pellucidum 0.3146373941491903 0.5836218710580947 0.5594747421770496 1.0 0.9390928945652012 39 O95202,P51571,Q9NZ01,Q9BV10,P53701,O43505,Q15392,Q96N66 8 +Atelectasis 0.4167442950009454 0.5834660963275317 0.5595795740424685 1.0 0.9390928945652012 10 Q13510 1 +Absent brainstem auditory responses 0.6627152258040774 0.5825196936849621 0.560216680248284 1.0 0.9390928945652012 3 O60313 1 +Weight loss 0.2828663606097847 0.5819564672739699 0.560596003878274 1.0 0.9390968204072604 61 Q9NZ08,P42892,P35610,P04062,Q9NZJ7,P35637,O75844,P07602,P35670,Q06136,P49327,Q13043,Q01844,Q99720,P21912,Q13423 16 +Aphasia 0.3159322967637206 0.5783887935028943 0.5630016581996693 1.0 0.941514641247176 32 Q9H9P8,O75648,P00403,Q7LGA3,P53701,P21964,P03886,P05067,O96008,P22626 10 +Abnormality of neutrophil morphology 0.4956585494982629 0.5777419422020938 0.5634383576886604 1.0 0.941514641247176 5 Q14739 1 +Keratitis 0.3971589668678043 0.5773468635912213 0.5637051617761446 1.0 0.941514641247176 11 Q14739,Q9NZ08,P49327 3 +Ectopic kidney 0.3787869958375548 0.5763778984631349 0.5643597799609101 1.0 0.941514641247176 14 Q8TAA9,Q9UHX1 2 +Waddling gait 0.3295027169927342 0.5760128443827146 0.5646064998396199 1.0 0.941514641247176 24 P50402,P07196,Q4J6C6,Q9BTV4,Q9H3H5,P09651,Q5T8D3,P02545,Q13510,P53007,P22626,Q7RTS9 12 +Oligohydramnios 0.3204091233411542 0.5758117369504336 0.5647424394053291 1.0 0.941514641247176 29 Q96L58,Q9BXW9,P51114,P23786,P16435,Q9NSD9,Q6NUK1,Q15058,Q9UHX1,Q07021,P38646,Q7LGA3 12 +Hamartoma 0.3505140230080623 0.5754582663456496 0.5649814077617872 1.0 0.9415663652356908 18 O43924,Q15437 2 +Fat malabsorption 0.4564823382620927 0.5737078423520982 0.5661655205109772 1.0 0.9424990723800384 7 Q96A33 1 +Fractures of the long bones 0.5392901624176284 0.5732294412887853 0.5664893525310097 1.0 0.9426915796620404 4 Q13126 1 +Decreased plasma carnitine 0.3894189699743134 0.5636634857481008 0.5729831719975138 1.0 0.9494546647010618 12 Q16836,P23786,P09622,O75880,P40939,O75648 6 +Motor axonal neuropathy 0.3705393669497911 0.5635363730223042 0.5730696993436399 1.0 0.9494546647010618 15 O15269,O60313,Q8IY17,P22626 4 +Hypoplasia of the odontoid process 0.4597449502241385 0.5613551371648016 0.5745554609713608 1.0 0.9499730407513092 6 O95831,P16278 2 +Abnormality of the musculature of the upper arm 0.459151790366639 0.5585718756296918 0.5764539385975673 1.0 0.9502906906047608 6 P50402,O14979 2 +Proximal upper limb amyotrophy 0.459151790366639 0.5585718756296918 0.5764539385975673 1.0 0.9502906906047608 6 P50402,O14979 2 +Abnormal circulating iga level 0.3825607911249774 0.5582723867524473 0.5766583977650632 1.0 0.9502906906047608 13 P49327,Q15904,Q9BV10 3 +Abnormal cornea morphology 0.3242086955434247 0.5582040059212062 0.5767050857217972 1.0 0.9502906906047608 130 P17050,Q9Y4P3,P35670,Q9H3H5,Q7LGA3,P16278,Q71SY5,P04062,O75381,Q14739,Q9UBM7,O75569,Q8NCH0,O75844,P06280,P49327,Q9NVI7,O43505,Q13510,P51648,Q9Y5Y5,Q9NZ08,P10619,O95202,Q9NWM8,Q6NUK1,Q06136,P12235,P53701,P21964,P40855 31 +Pelvic kidney 0.4298932011019742 0.5576048265424574 0.5771142599230097 1.0 0.9502906906047608 9 Q9UHX1 1 +Abnormal peripheral nervous system morphology 0.336971124309147 0.5575640754342694 0.5771420934547464 1.0 0.9502906906047608 149 O15269,Q9HC21,P48651,P17050,Q96RL7,Q8N2K0,P41440,Q9H3H5,P00403,Q9UHX1,P22626,Q6PI48,O43681,Q71SY5,P00846,Q9NZJ7,P31930,O95831,P07602,Q8IV08,Q9UHD9,Q99720,O75381,P50542,Q02978,Q9BQT8,P34897,Q6DKK2,O76024,P51798,Q9BV10,P21912,Q9NVI7,Q13510,O43819,Q9Y5Y5,Q9Y619,P51812,P03886,Q5THJ4,Q9NR77,Q16637,O60313,O15121,Q15043,P35637,Q15067,P12235,P17480,P40855,Q8IY17,P53007 52 +Cachexia 0.3627740214242792 0.5564365371246003 0.5779124673602527 1.0 0.9509638025046744 16 P04062,Q9NZJ7,P35637,P07602,Q99720 5 +Abnormal tricuspid valve morphology 0.411742085138234 0.5555226485547804 0.5785372230136001 1.0 0.9509638025046744 10 P53701 1 +Abnormal cry 0.4114349498511123 0.553812846984331 0.5797069352080757 1.0 0.9524357774391026 10 O75208,O60313,Q13510 3 +Abnormal stomach morphology 0.2758066238326364 0.551657599169923 0.5811829652971987 1.0 0.9530893606078304 67 O75381,Q9Y5Y5,Q6PGP7,Q9UBM7,P04062,Q8NBU5,Q8NCH0,Q9Y4P3,Q6ZXV5,P49327,O76024,P21912,Q14739,P51812,P40855 15 +Distal upper limb amyotrophy 0.3874049940497752 0.5513891549953798 0.5813669334396603 1.0 0.9530893606078304 12 Q9NR77 1 +Abnormality of hair pigmentation 0.33067416740435 0.551388078929068 0.5813676709361368 1.0 0.9530893606078304 20 Q6PGP7,P37268,P49327,Q13126,Q86YV9 5 +Chronic rhinitis 0.5328321642794343 0.5475368899966012 0.5840099335988229 1.0 0.9550357665666488 4 Q9BV10 1 +Contractures of the large joints 0.652178040397069 0.5458240667403531 0.5851868782773195 1.0 0.9550357665666488 3 P50542 1 +Fatty replacement of skeletal muscle 0.4882354176983514 0.5454017341047943 0.5854772480424728 1.0 0.9550357665666488 5 P22626,P51114 2 +Abnormal thyroid morphology 0.3125238563473456 0.5450233848785702 0.585737434345275 1.0 0.9550357665666488 33 P42892,Q13043,P49327,P12235,P21912,Q15437 6 +Calvarial skull defect 0.4559514850925469 0.5435969925562494 0.5867188297888888 1.0 0.9550357665666488 6 Q14739 1 +Centrally nucleated skeletal muscle fibers 0.4442684956307991 0.5432114588934781 0.5869842178345812 1.0 0.9550357665666488 8 Q13586,P22626,P51114 3 +Neoplasm of the rectum 0.3799271397479399 0.5417156698745197 0.5880143932167741 1.0 0.9560248375172542 13 Q15437 1 +Abnormality of circulating adrenocorticotropin level 0.4494165515185634 0.5395163810928607 0.5895305969824278 1.0 0.9572955526562148 7 Q13423 1 +Antineutrophil antibody positivity 0.6496751069967128 0.5372114731007471 0.5911215470907192 1.0 0.9572955526562148 3 P49327 1 +Pancreatitis 0.3372876091134955 0.5365298786616471 0.591592391825325 1.0 0.9573732488152508 19 Q9NZ08,Q9UJS0,P49327,P00403,P03886 5 +Reduced consciousness confusion 0.3111814865980987 0.5359547396098134 0.5919898312657357 1.0 0.9575947757241308 114 Q9HC21,P35610,Q9UJS0,Q9UMS0,P09622,Q86Y39,P35670,P00403,O96000,Q13423,O96008,Q16836,P01889,O43681,P04062,Q9NZJ7,O43676,Q9Y6M9,P07602,Q9HCC0,Q9UBM7,Q96CU9,P23786,P40939,P35270,P49327,O43819,Q9Y619,P03886,Q9NZ08,Q9NWS8,Q8IUX1,P12235 33 +Abnormal arachnoid mater morphology 0.4427619361791046 0.5357197577793444 0.5921522464725191 1.0 0.9575947757241308 8 Q15904,Q9UHX1 2 +Heparan sulfate excretion in urine 0.6488263622775936 0.5343003297658429 0.5931337641026784 1.0 0.9581554348401456 3 P54802 1 +Serositis 0.3523273970500646 0.5329525273744324 0.594066442736322 1.0 0.9593198476141463 17 Q9NZ08,P01889,P14174,Q8N1F7,P57740,P49327 6 +Neck flexor weakness 0.5288064232149458 0.5316668925875356 0.5949567259745245 1.0 0.9598932790459908 4 Q99720 1 +Postaxial polydactyly 0.3442666391625175 0.5289474632421882 0.5968418952782983 1.0 0.9609035337797068 18 Q9UM00,P30153,P61978,Q9BRT2,O43924,Q10713,Q9UBM7,Q14739 8 +Decreased number of large peripheral myelinated nerve fibers 0.4843852921493394 0.5287814374251045 0.5969570760870837 1.0 0.9609035337797068 5 O15269,Q8TB36,P07196 3 +Dysmetric saccades 0.4468465651213659 0.5271658648297947 0.5980784110680488 1.0 0.9614257591577192 7 O14773 1 +Widened subarachnoid space 0.3190814877811341 0.5266981122637879 0.5984032467405815 1.0 0.9614257591577192 27 Q01105,O95831,P00403,Q9BV10,P03886,Q2TAA5 6 +Hamartoma of the eye 0.4405852787333935 0.5249240980652455 0.5996359564731444 1.0 0.9616994791577952 8 Q15437 1 +Protruding tongue 0.4234569585827609 0.5238394498787985 0.600390212184807 1.0 0.9616994791577952 9 Q96RL7,Q9NRZ9,Q10713,Q6NUK1 4 +Pharyngitis 0.6452480120199335 0.5220800262136641 0.6016146127653941 1.0 0.9616994791577952 3 Q9BV10 1 +Turricephaly 0.4229222955239717 0.5210485313768624 0.6023329637553836 1.0 0.9616994791577952 9 P21964,Q6NUK1 2 +Abnormality of circulating glucocorticoid level 0.422770246120985 0.5202552476497974 0.6028856831121105 1.0 0.9616994791577952 9 Q13423 1 +Abnormality of facial soft tissue 0.307778581056757 0.5196077668630726 0.6033369835912916 1.0 0.9616994791577952 111 Q9Y4P3,Q9H3H5,Q9UHX1,Q15437,P04062,P16435,O75381,Q9UBM7,Q9BQT8,O75844,P35270,P51798,P10253,P21912,Q9Y5Y5,P28070,Q13510,O43819,O60313,Q15043,Q86VD7,P12235,P40855 23 +Contractures of the joints of the lower limbs 0.2935251213190595 0.5175055642577707 0.6048032857009504 1.0 0.962583225888894 53 P50402,Q9HC21,Q8IZA0,P37268,P23786,Q96AY3,O60313,P35637,Q86XL3,Q9H3H5,Q99720,P21912,Q7LGA3,O75477 14 +Bilateral tonic clonic seizure 0.2877539528057919 0.5161776091483137 0.605730367226224 1.0 0.9628152843032116 85 Q9HC21,P27544,Q01105,P00846,P04062,Q9NZJ7,Q9Y320,O43292,P07602,P51649,P00403,Q969M3,Q14739,Q13510,P03886,Q9NQZ5 16 +Non hodgkin lymphoma 0.4443565045663344 0.5152457165960884 0.6063813263705522 1.0 0.9628152843032116 7 P49327 1 +Microcornea 0.3208997702327258 0.5141290895014623 0.607161740680771 1.0 0.9629521407364382 25 O43505,Q8NCH0,Q9NWM8 3 +Gray matter heterotopia 0.3175897167533237 0.5133397323302045 0.6077136954001041 1.0 0.9632961407571146 27 Q6NUK1,Q6ZXV5,Q86XL3,Q15058,Q9UBM7,O43505 6 +Constipation 0.2887576559195897 0.5084440937915807 0.6111419365677415 1.0 0.9640685440510998 87 Q03164,Q9Y4P3,P55795,P00403,Q13423,Q7LGA3,Q71SY5,P04062,P16435,P42892,P37268,Q8NCH0,O76024,P21912,Q9Y5Y5,Q8TAA9,P03886,P12235,P21964 19 +Multiple cafe au lait spots 0.3852202481165981 0.5070948194600993 0.6120882897812729 1.0 0.9640685440510998 11 Q15437,P21912 2 +Agenesis of corpus callosum 0.2803724544557595 0.5022687544200728 0.6154784850297745 1.0 0.9640685440510998 77 Q9HC21,O95202,P23786,P00403,Q10713,P53701,Q9UHX1,O43505,Q7LGA3,Q15392,P03886 11 +Upper limb amyotrophy 0.3671005614185597 0.5005614860901113 0.6166797733971974 1.0 0.9640685440510998 14 Q9NR77 1 +Microglossia 0.5203323194628973 0.4986517437190492 0.6180247458036505 1.0 0.9650047074900446 4 Q9UBM7,P48651 2 +Abnormal heart valve physiology 0.2784840313261981 0.4984674162012597 0.6181546298345344 1.0 0.9650047074900446 75 Q9NZ08,Q6PGP7,Q96DX4,P04062,Q15904,Q9Y4P3,O75844,Q6NUK1,Q6ZXV5,P40939,P49327,P06280,Q9UHX1,P53701,O43819,P16278 16 +Diplopia 0.3237079515542966 0.495687187831241 0.6201151278972512 1.0 0.966235822133088 20 P01889,O14773,P04062,Q9NW15,O43464,P53007 6 +Tremor by anatomical site 0.3199875596888744 0.4948490802826484 0.6207066563558281 1.0 0.9668248159543136 24 P22307,P07196,Q96RL7,Q16637,Q9NR77,P35637,P20700,Q99720,O94905 9 +Abnormal circulating protein concentration 0.3228900778859529 0.4943774833315462 0.6210396129703328 1.0 0.9670107866333104 135 O00400,Q5JRX3,Q9UJS0,Q6PGP7,O95470,O14979,Q9Y4P3,Q8N511,P41440,Q9H3H5,Q6ZXV5,P13473,P22626,Q16836,O95831,Q9HC07,Q9BT22,Q00059,P53985,P14174,P23786,Q9Y487,P40939,P10253,Q9BV10,O43505,P42167,P50402,Q9NWM8,Q86VD7,Q9NSD9,Q5XKP0,Q13043,P12235 34 +Hypochromic anemia 0.3829479563402722 0.4938669202490419 0.6214001679533991 1.0 0.96723958765658 11 P49327,O75027,Q96DA6 3 +Aplasia hypoplasia of the phalanges of the toes 0.6403095558546474 0.4934093044300751 0.6217234093353508 1.0 0.967410170952051 2 P02545 1 +Abnormality of the hepatic vasculature 0.4001311502656182 0.4914134355435343 0.6231340634820015 1.0 0.9682342003834372 10 Q13043,Q96J02,Q10713,Q9NSD9 4 +Gastritis 0.5184253639803573 0.4912988269452084 0.6232151094138305 1.0 0.9682342003834372 4 P49327 1 +Abnormality of the upper arm 0.3224165701906868 0.4905493314870835 0.623745230614793 1.0 0.9682342003834372 21 P50402,P48651,O14979,P16435,Q9BTV4,P36776,Q9BV10,P02545,O00116,O15228,P50542,Q7RTS9 12 +Abnormal t cell morphology 0.4169542025198443 0.4900517658934734 0.6240972684724078 1.0 0.9682342003834372 9 P49327,Q13432 2 +Abnormal t cell subset distribution 0.4169542025198443 0.4900517658934734 0.6240972684724078 1.0 0.9682342003834372 9 P49327,Q13432 2 +Limited elbow extension 0.3770372762782822 0.4887704399830344 0.625004227857568 1.0 0.9682342003834372 12 P16435,Q96J02,Q96DX4,Q9H6K4 4 +Congenital blindness 0.6353532509994778 0.4887533087351154 0.6250163576998677 1.0 0.9682342003834372 3 P31939 1 +Decreased circulating igg level 0.4166984437840731 0.4887300717520792 0.6250328108923999 1.0 0.9682342003834372 9 P49327 1 +Encephalocele 0.3713553696273154 0.4882734244928369 0.6253561827403227 1.0 0.968311390831484 13 Q6ZXV5,O43505 2 +Bulbar palsy 0.3819469751516373 0.4880557686697007 0.6255103397045254 1.0 0.968311390831484 11 O43681,Q13501,P35637,P43243,P53007,P31483 6 +Proximal amyotrophy 0.36433709127539 0.4828305439329139 0.6292160615044602 1.0 0.9713911784835308 14 P50402,Q13586,Q16637,O14979,P35637,Q9BTV4 6 +Hyperkinetic movements 0.3979718098965452 0.4796202264053196 0.6314974613735167 1.0 0.9732583610469748 10 Q9NZJ7,P51649,Q96RL7,P07602 4 +Abnormal circulating sulfur amino acid concentration 0.4368525975804221 0.4796163262448927 0.631500235149296 1.0 0.9732583610469748 7 Q9UJS0,Q6PGP7 2 +Neoplasm of the adrenal cortex 0.4725496800269436 0.4784088407984803 0.6323592424368829 1.0 0.973435506540276 5 P48735,P10644,P42771,O75874 4 +Abnormal iris pigmentation 0.321369333112295 0.4771278897598927 0.6332710558416323 1.0 0.973435506540276 20 Q9Y5Y5,Q9Y4P3,O75381,P40855,Q8IY17 5 +Hypoplasia of the frontal lobes 0.4141532372298702 0.4756083010113059 0.6343534604224228 1.0 0.9743393720463808 9 Q86XL3,Q15058 2 +Nonprogressive cerebellar ataxia 0.5141847067765527 0.4750532183356829 0.6347490416080797 1.0 0.974616365005556 4 O75027,Q96DA6 2 +Abnormal morphology of the musculature of the neck 0.3745533436382051 0.4739237665729309 0.6355542704959025 1.0 0.9748610219530646 12 Q96L58,P35637,O75569,Q99720 4 +Sensory axonal neuropathy 0.3687339508630736 0.4720790239210964 0.6368703841085748 1.0 0.9759178791997216 13 P34897,O95831,Q15067,Q8IV08,P09651,P22626 6 +Abnormal urine ph 0.3013257380445625 0.4715006489547683 0.6372832563493134 1.0 0.9761903196040904 43 Q9H9P8,Q16836,Q9HC21,Q9BQT8,P53007,P00846,P23786,O75880,Q9HCC0,P40939,P51649,P12235,O96000,Q9NPF0,P03886 15 +Abnormality of the endometrium 0.4119621910663738 0.4643589846787204 0.6423905705631079 1.0 0.979076063319468 9 Q15437 1 +Hypertriglyceridemia 0.3190116879399756 0.4631638180982705 0.6432469487917531 1.0 0.979076063319468 21 O95470,P28070,P22830,Q9UJS0 4 +Red eye 0.3424667112146397 0.4629341476627556 0.6434115699556373 1.0 0.979076063319468 17 Q9NZ08,P01889,P02786,P49327,Q14739,P28070 6 +Fatigable weakness of swallowing muscles 0.3554109755450839 0.4628223798257052 0.6434916882594384 1.0 0.979076063319468 15 P35637,Q15165,P09651,Q92804,P50995,Q9UHD9,P43243 7 +Multifocal epileptiform discharges 0.3116481406554907 0.4604186953816771 0.6452157180340046 1.0 0.9803814668650916 27 Q9UBX3,Q9NZ01,Q96N66 3 +Hydrops fetalis 0.3021367182461038 0.4598620112606937 0.6456152692815176 1.0 0.9804476795309256 40 P10619,P04062,Q14739,Q13510,O96000,Q9BT22,P16278 7 +Abnormality of the bladder 0.2995723539874994 0.4587328805296312 0.6464259991260959 1.0 0.981232626229622 106 Q9UJS0,Q9Y4P3,Q15058,Q9UHX1,P22626,O43681,P04062,Q9NZJ7,P16435,P07602,Q86XL3,Q99720,Q8NCH0,O76024,P21912,Q8TAA9,P51812,O75298,Q9NR77,Q9NWM8,P35637,P12235,P21964 23 +Limitation of joint mobility 0.2897240065500708 0.4583428198034867 0.6467061652137192 1.0 0.9813289263028552 93 Q96L58,Q9HC21,O14979,P54802,Q9Y4P3,Q7LGA3,P16278,P01889,Q96DX4,Q8NBU5,P16435,O95155,Q9BT22,P37268,P23786,Q96AY3,O75844,Q9BTV4,O76024,Q9H6K4,Q8TAA9,P51648,Q96J02,P50402 24 +Craniofacial osteosclerosis 0.6257210585365921 0.4570048321970401 0.6476675722755403 1.0 0.9815166877525924 3 Q15043 1 +Transient ischemic attack 0.4319805225096238 0.4567351399237724 0.6478614301206407 1.0 0.9815166877525924 7 O75844 1 +Brisk reflexes 0.3162868065500431 0.4545457967399274 0.6494360374928307 1.0 0.9815241581333568 23 Q5JRX3,P20674,P35637,Q9NW15,Q9BSJ2,O00483,Q10713,Q99720,Q8NI60 9 +Hammertoe 0.3478610749653957 0.453998541683512 0.649829876420084 1.0 0.981527054341774 16 Q8TB36,P07196,Q9NR77,O95140,Q99720,Q9UBM7,Q96BR5,P39210 8 +Abnormal urine carbohydrate level 0.3758325544164069 0.4527828964867242 0.6507050806522876 1.0 0.9824583545160248 11 P16278,P10253,Q9UJS0 3 +Neurodegeneration 0.3089917376615868 0.4522906555742003 0.651059606809246 1.0 0.98247615447088 28 P35637,Q15165,P17900,Q6DKK2,Q5JTZ9,Q92804,P50995,Q9UHD9,P09651,P17480,O75792 11 +Supraventricular arrhythmia 0.3653413241730051 0.451234381472666 0.6518206323506257 1.0 0.982664221230235 13 P12235,P00846 2 +Abnormal sharpey fiber morphology 0.4659495846431791 0.4508319956379056 0.652110639214047 1.0 0.982664221230235 5 P35670,P01889 2 +Congenital contracture 0.3020529185059382 0.4501842570073662 0.6525775868461388 1.0 0.982664221230235 38 P04062,Q8NCH0,Q96AY3,O75844,Q96AA3,Q96A33,Q15392 7 +Abnormal vitamin b12 level 0.4655045311255797 0.4489866145873576 0.6534413126147285 1.0 0.983165138125697 5 P49327 1 +Aplasia hypoplasia of the cerebral white matter 0.430046158860939 0.4477092600314415 0.6543630378057177 1.0 0.9837170767544124 7 P00403,P03886 2 +Overriding aorta 0.4246568420691041 0.4470472358667947 0.6548409547889387 1.0 0.9840611813936898 8 P53701 1 +Hypertensive crisis 0.5067103904344862 0.4467901411776296 0.655026590265146 1.0 0.9840611813936898 4 P21964 1 +Abnormal cns myelination 0.3149525065754219 0.4435397999559742 0.6573753381025282 1.0 0.986109041870077 129 O00400,Q86Y39,Q9H3H5,O96000,Q7LGA3,Q9H9P8,O43681,Q9H490,Q9NZJ7,O43676,Q9Y6M9,O95831,P07602,Q99720,P51572,Q96CU9,Q9P0J0,P51649,P10253,P21912,Q9Y5Y5,O43819,P51648,P03886,Q9NWS8,Q8IUX1,Q15067,P54136,P40855 29 +Platyspondyly 0.3017302808586252 0.4407178812826235 0.6594172497655479 1.0 0.987054977500298 32 Q96L58,Q32P28,Q96DX4,Q96AY3,O95831,Q96HY6,Q6NUK1,P04066,Q14739,P16278 10 +Azoospermia 0.3906502961987384 0.4399738877149899 0.6599560197683547 1.0 0.9875349826540352 10 P04062 1 +Edema of the dorsum of hands 0.6238223418573401 0.43835901299087 0.6611260532410674 1.0 0.9876538334132476 2 Q9Y263 1 +Edema of the dorsum of feet 0.6238223418573401 0.43835901299087 0.6611260532410674 1.0 0.9876538334132476 2 Q9Y263 1 +Abnormality of cardiovascular system electrophysiology 0.2971524124557636 0.4361858656890102 0.6627018820809556 1.0 0.9884917699064566 105 Q9Y4P3,Q9H3H5,P00403,P13473,Q16836,P01889,Q96DA6,P04062,P00846,Q9H490,Q9NZJ7,P07602,Q6PJG6,O75381,P42892,P23786,P06280,P40939,P10253,P21912,Q9Y5Y5,O43819,P03886,P50402,O75880,P12235,P53701,O75208,P40855 29 +Typical absence seizure 0.3567863700095929 0.4348308622020648 0.6636852016121879 1.0 0.9885597988798384 14 Q01105 1 +Abnormal venous morphology 0.3116331072765692 0.4346063078416507 0.6638482156533785 1.0 0.9885597988798384 25 P04062,Q9Y487,Q6NUK1,Q13043,P21964 5 +Colitis 0.421753277171365 0.433087213849972 0.6649514113673389 1.0 0.9885597988798384 8 Q13043,P49327 2 +Abnormal aortic valve cusp morphology 0.3144618800718932 0.4323821203046653 0.6654637108939316 1.0 0.9885597988798384 22 P37268,Q6PGP7,Q9UHX1,Q6NUK1 4 +Abnormal oral frenulum morphology 0.3616835291614089 0.4289136847709277 0.6679860408713092 1.0 0.988803642780282 13 O75844 1 +Thin ribs 0.3502032025321223 0.4287582979221501 0.6680991300047112 1.0 0.988803642780282 15 O75844 1 +Choanal stenosis 0.5017426630220204 0.4282804019591228 0.6684469855455926 1.0 0.988803642780282 4 P16435 1 +Calcific stippling 0.6162453137578119 0.4264871717138316 0.6697528936797918 1.0 0.9894758116861668 3 P50542 1 +Deviation of the 2nd finger 0.5003120992730338 0.4229925456481925 0.6723006997781167 1.0 0.9905915647159312 4 Q9H6K4 1 +Muscle hypertrophy of the lower extremities 0.4037335695626057 0.4225224201765002 0.6726437395231675 1.0 0.9905915647159312 9 Q9NR77 1 +Abnormality of the pubic bone 0.4293549083049304 0.4222884653781771 0.6728144763580177 1.0 0.9905915647159312 6 Q8IZA0 1 +Limb hypertonia 0.2996605411863546 0.4211458422282099 0.6736485884786982 1.0 0.9905915647159312 36 Q9HC21,O00400,P54136,P35270,Q9BW92,P21912,Q14739 7 +Anteriorly placed anus 0.4032823218570812 0.4202479542371047 0.6743043262752284 1.0 0.9905915647159312 9 P16435,P48651,P53701,Q6NUK1 4 +Pes valgus 0.4184830913966786 0.417460946851766 0.6763412837355718 1.0 0.991205756527951 8 Q9UHX1 1 +Pace of progression 0.3303269272958478 0.4173545103759188 0.6764191227189418 1.0 0.991205756527951 155 O00400,Q96RL7,O95470,O14979,P54802,Q8N2K0,O00584,P41440,Q9H3H5,Q10713,Q13126,P05023,Q9NQZ5,Q13586,Q6PI48,O75787,P04062,Q9Y6M9,Q8NBU5,O95831,Q6PJG6,Q8IV08,Q5JTZ9,Q9UHD9,Q99720,Q00059,O75569,P15586,Q5T160,O14773,Q9P0J0,Q9BTV4,Q9Y5Y5,Q13510,O75298,Q8N183,P50402,P27544,Q9NR77,Q16637,Q14108,O15121,Q15043,O60313,Q5XKP0,P12235,Q9NR28,P28288,Q8IY17,O75477 50 +Abnormality of earlobe 0.3113496993038505 0.413930814062977 0.6789247762538637 1.0 0.9934436184485584 23 P21964,Q7LGA3,Q15392,P53701 4 +Delayed closure of the anterior fontanelle 0.3639729063391487 0.4114630417846068 0.6807330359551562 1.0 0.9934436184485584 12 O75381,P51812,Q9Y487,P40855 4 +Bladder diverticulum 0.4171004265524446 0.410885796753267 0.6811562775977467 1.0 0.9934436184485584 8 Q9NWM8 1 +Congestive heart failure 0.2738793684530319 0.4087140174413904 0.6827495456615627 1.0 0.9934436184485584 59 Q96DA6,Q9Y4P3,O75880,Q00325,P40939,P06280,P00403,Q13043,Q70HW3,P10253,P21912,P03886,O43819,P16278,P22626 15 +Abnormal sella turcica morphology 0.4554626525609741 0.4078538772344258 0.683380956118915 1.0 0.9934436184485584 5 O75431,P16278 2 +Limb joint contracture 0.2852037373046019 0.4076926683139478 0.683499320790016 1.0 0.9934436184485584 92 Q9HC21,Q9H3H5,Q7LGA3,Q8IZA0,Q71SY5,P16435,Q86XL3,Q15392,P42892,P37268,P23786,Q96AY3,O75844,P21912,Q9Y619,P50402,Q9NR77,O60313,O75477 19 +Persistent head lag 0.4209389609668568 0.4056944938050835 0.6849670885151058 1.0 0.9934436184485584 7 Q5XKP0 1 +Abnormal circulating fatty acid anion concentration 0.356461936793058 0.3973469698224482 0.6911116152814598 1.0 0.9965599806978228 13 Q16836,P23786,P09622,O75880,P40939,O75648 6 +Facial hemangioma 0.4524385909726492 0.3956654205780147 0.692351868422062 1.0 0.9965599806978228 5 Q9UBM7,P16435 2 +Peripheral neuropathy 0.326729209816989 0.3952903799446281 0.6926285982371576 1.0 0.9965599806978228 152 O15269,Q9HC21,Q9Y2R0,P17050,O95470,P54802,Q8N2K0,P35670,P41440,P00403,Q10713,P05023,P22626,Q16836,O43681,P00846,Q9NZJ7,O95831,P07602,Q8IV08,Q96CU9,Q9P0J0,P40939,O76024,Q9NVI7,O43819,P03886,Q15041,Q9NWS8,Q9NR77,O60313,O15121,Q15067,P12235,Q8IY17,P53007 36 +Abnormal circulating igg level 0.3556754105932199 0.3926240810228972 0.6945971509053517 1.0 0.9965599806978228 13 P49327,Q9BV10 2 +Abnormality of subcutaneous fat tissue 0.3556601103442845 0.3925322929015953 0.6946649556872742 1.0 0.9965599806978228 13 Q9Y487,O75844 2 +Non midline cleft lip 0.4915824915824743 0.3911541132346279 0.6956833239246032 1.0 0.99671179780888 4 Q96L58,Q9NXE4,O60716 3 +Joint dislocation 0.2738037991560397 0.390989211410899 0.6958052104403423 1.0 0.99671179780888 79 P53007,Q9NQT5,O95202,Q9UBM7,Q8NCH0,Q9Y487,Q9Y4P3,O75844,Q9NX62,Q6ZXV5,P51798,Q96A33,Q9UHX1,P21964,Q9Y619,P51571 16 +Immunodeficiency 0.2795765845046581 0.3894546995596271 0.6969398151254125 1.0 0.9977058118519976 55 Q6PGP7,O95202,P09601,Q9H0U3,Q13432,Q13043,Q96A33,P21912,P21964,Q9BT22,Q15437 11 +Bilateral cleft lip 0.6076716016150805 0.3870697131380259 0.6987045987784906 1.0 0.998906518753573 2 Q9NXE4 1 +Increased total bilirubin 0.4894135494786124 0.3833619630885704 0.7014514020136562 1.0 0.9997891624316612 4 P23786 1 +Vertebral segmentation defect 0.299263255319383 0.3809634329853713 0.7032303823786104 1.0 0.9997891624316612 29 O95202,Q9Y4P3,Q9UHX1,Q8TAA9,Q9Y619 5 +Reduced protein s activity 0.4886198158264331 0.3805225452464015 0.7035575642871437 1.0 0.9997891624316612 4 Q9H3H5 1 +Abnormality of the protein c anticoagulant pathway 0.488619815826433 0.3805225452464003 0.7035575642871446 1.0 0.9997891624316612 4 Q9H3H5 1 +Hydroureter 0.3792250742431697 0.3792785842921716 0.7044810009912565 1.0 1.0 10 O76024,P36776,Q7LGA3,Q16531 4 +Intestinal polyp 0.3303141870931748 0.3784320942869332 0.7051096300380939 1.0 1.0 17 Q15437,P21912 2 +Abnormality of corneal size 0.295109923568578 0.3763479341175336 0.7066582479422108 1.0 1.0 36 O95202,Q8NCH0,Q9NWM8,Q9Y4P3,O43505 5 +Short palm 0.3160676891100003 0.376009555856059 0.7069097919123175 1.0 1.0 19 Q9Y619,Q9UHX1 2 +Complex febrile seizure 0.6029609690444213 0.37263884644026 0.709417256624512 1.0 1.0 2 Q8WVX9 1 +Abnormal spermatogenesis 0.3615944779289334 0.372336000584395 0.7096426977754138 1.0 1.0 11 Q9BXW9,P04062,P51809,P16435,Q13423 5 +Postural instability 0.3294158660482778 0.3722777164028558 0.7096860879566482 1.0 1.0 17 P04062,Q9NR77 2 +Meningocele 0.3933266593826255 0.3706395605761609 0.7109060123743385 1.0 1.0 9 P21964,Q8TAA9 2 +Oligomenorrhea 0.4851851851851804 0.3683122010871936 0.7126404558482433 1.0 1.0 4 O00170,Q8N5K1,P31751 3 +Poor suck 0.3023492122209113 0.3665752995619071 0.7139358355744543 1.0 1.0 26 P53007,Q9H936,O43464,P40939,O75648,Q9UBM7,O43819,P22695,P50542 9 +Abnormal 2nd finger morphology 0.4159581966335677 0.3637374229112325 0.7160540953410641 1.0 1.0 6 Q9H6K4 1 +Abnormal upper motor neuron morphology 0.3597044090436752 0.3618573015246257 0.7174586691227618 1.0 1.0 11 Q13501,P35637,Q99720,O94905,P43243,Q8IY17 6 +Hyperlipoproteinemia 0.3909807280842705 0.3591188171880595 0.7195062052077872 1.0 1.0 9 Q8N511,Q9UJS0 2 +Increased ldl cholesterol concentration 0.3909807280842705 0.3591188171880595 0.7195062052077872 1.0 1.0 9 Q8N511,Q9UJS0 2 +Flared iliac wing 0.4428146535624064 0.3575347394216591 0.720691524168275 1.0 1.0 5 O95831,P16278 2 +Abnormal consumption behavior 0.3043274069995954 0.3569032785694177 0.7211642151554074 1.0 1.0 23 P35610,Q9UJS0,O76024,P53007,Q4J6C6 5 +Decreased circulating iga level 0.4096032571054749 0.3546134929888019 0.7228791663500507 1.0 1.0 7 Q15904 1 +Diaphragmatic weakness 0.5928950298152595 0.3546086768880499 0.7228827748738347 1.0 1.0 3 Q9NR77 1 +Chronic kidney disease 0.2925834666803172 0.3536601534493493 0.7235935879716462 1.0 1.0 32 O95470,Q8IUX1 2 +Cholecystitis 0.4029660437590652 0.3448467264208508 0.7302096026762277 1.0 1.0 8 Q9NZJ7,P07602 2 +Abnormal blood monovalent inorganic cation concentration 0.3249437203171344 0.3418506857312273 0.7324632632081798 1.0 1.0 17 Q13423,Q9BV10 2 +Otitis media 0.2857254599395802 0.3410245622738401 0.7330850908947946 1.0 1.0 47 Q9UBM7,O95202,Q9Y4P3,Q9H0U3,Q13432,Q8N5M9,Q96A33,Q14739,P21964,Q03518 10 +Ectopic anus 0.3467512162435762 0.339675164221267 0.7341011669172395 1.0 1.0 13 P48651,P16435,Q16531,Q6NUK1,P53701 5 +Hypochromic microcytic anemia 0.5873265333480634 0.3382217717011523 0.7351960701968001 1.0 1.0 3 O75027 1 +Autism 0.2905612475808223 0.335203580603752 0.7374715211984639 1.0 1.0 38 P17050,Q9Y4P3,Q9H3H5,O76024,P21912,Q9UBM7,P21964,Q15437 8 +Sound sensitivity 0.4003184803811362 0.3327335712891792 0.7393354058616151 1.0 1.0 8 P17900 1 +Hyperacusis 0.4003184803811362 0.3327335712891792 0.7393354058616151 1.0 1.0 8 P17900 1 +Muscular ventricular septal defect 0.4363933696070083 0.3326848302761315 0.7393722015904376 1.0 1.0 5 Q9BV10 1 +Dysarthria 0.3219723809474619 0.332659270988775 0.7393914971317399 1.0 1.0 152 O75503,O43292,Q9Y4P3,P35670,Q10713,O43681,P00846,P04062,Q9NZJ7,P07602,Q8IV08,O75569,Q96CU9,O14773,Q9P0J0,P35270,O76024,Q9H6K4,Q9Y5Y5,O43819,P51648,O75027,O15118,Q14108,O15121,Q9NW15,Q5XKP0,P54136,P12235,O75477 30 +Patent ductus arteriosus 0.2673444334527841 0.3253292496203071 0.7449318958578806 1.0 1.0 77 P42892,Q8N6S5,Q96DX4,Q6PGP7,Q9NWM8,Q9Y4P3,O75844,Q6NUK1,Q6ZXV5,P51571,Q9UHX1,Q9BV10,P21964,P40855,Q15392 15 +Obstructive sleep apnea 0.3527844491183463 0.3239430455455955 0.7459811540088204 1.0 1.0 11 Q96A33,P53007,Q16531 3 +Insulin resistance 0.3281633269485628 0.3233010392988229 0.7464672669823103 1.0 1.0 16 P31751,P18031,P43304,Q03252,A5YKK6,O75844,O95140,O76024,P02545,O75431 10 +Atrioventricular canal defect 0.3977460806419987 0.3210481090362344 0.7481739332857182 1.0 1.0 8 Q9UBM7,P36776,Q9UHX1 3 +Nuclear cataract 0.4019586511252675 0.3210144721201136 0.7481994236946341 1.0 1.0 7 O76024,Q99797 2 +Vacuolated lymphocytes 0.5813606665788954 0.3210093654256 0.7482032936255281 1.0 1.0 3 P16278 1 +Abnormal circulating methionine concentration 0.4328324883465582 0.3191208883821274 0.7496348444916812 1.0 1.0 5 Q9UJS0 1 +Abnormal renal physiology 0.3163462558104565 0.318800849616192 0.7498775339696064 1.0 1.0 145 O95470,Q86Y39,Q9Y4P3,P00403,Q10713,P05023,O96000,P04062,Q9Y6M9,O43676,Q9BT22,Q96CU9,P23786,Q8NCH0,P06280,O76024,P49327,P21912,Q8TAA9,O43819,P03886,Q9NZ08,Q9NWS8,Q8IUX1,Q14108,P09601,Q13043,P40855,Q8IY17 29 +Iron deficiency anemia 0.4322817574819034 0.3170372809148289 0.7512153141950075 1.0 1.0 5 P49327 1 +Annular pancreas 0.47004496215953 0.316041331060603 0.7519711369920086 1.0 1.0 4 O95155,Q9BXW9 2 +Joint contracture of the hand 0.2869060758766948 0.3141577974962826 0.7534011938648293 1.0 1.0 42 P42892,Q8IZA0,Q71SY5,Q9NR77,O75844,Q9Y619,Q15392 7 +Multifactorial inheritance 0.3958414299667911 0.3124506825955207 0.7546980377312038 1.0 1.0 8 P10321,P42892 2 +Nausea and vomiting 0.3117443966353082 0.310840450769999 0.7559219166171869 1.0 1.0 139 P35610,Q9UJS0,P09622,Q86Y39,Q9Y4P3,P00403,Q92804,Q01844,O96000,Q13423,Q16836,P01889,Q8IZA0,P00846,Q9NZJ7,O43676,Q9Y6M9,Q15165,P07602,Q9HCC0,Q9UBM7,Q2TAA5,Q96CU9,P42892,P23786,P11117,P06280,P49327,P40939,P21912,Q9Y619,P03886,Q9NZ08,Q8IUX1,P35637,Q9NSD9,P54136,P51571,P22695 39 +Aplasia hypoplasia affecting the eye 0.2724068647880027 0.3087828713489979 0.7574866995429281 1.0 1.0 85 Q71SY5,P37268,O95202,Q9Y4P3,Q6NUK1,O43924,Q15058,P53701,Q9UHX1,P21964,Q86YV9,P21912,Q7LGA3,O75569,Q9NVI7,O43505 16 +2 3 toe syndactyly 0.2964031290884849 0.3071133136834014 0.7587571242363365 1.0 1.0 25 Q71SY5,P37268,O43924,Q9UHX1,Q9UBM7 5 +Cerebral hemorrhage 0.3495535239434407 0.3064979259852709 0.7592255587258077 1.0 1.0 11 P23786 1 +Congenital sensorineural hearing impairment 0.4011708229242577 0.3015503852503585 0.7629948349874787 1.0 1.0 6 O76024 1 +Neoplasm of the oral cavity 0.3790070500539043 0.3014319553183205 0.7630851299505403 1.0 1.0 9 O43924 1 +Cranial nerve compression 0.3636791866829572 0.2994139799908451 0.764624196673823 1.0 1.0 10 Q02978,P51798,P22626,P21912 4 +Vertebral hypoplasia 0.3636389114251353 0.2992116773434234 0.7647785399814837 1.0 1.0 10 Q14739,Q8TAA9 2 +Heterotropia 0.282531780762314 0.2971275406965131 0.7663691388876683 1.0 1.0 46 P04062,P55795,O43924,Q9H3H5,P40939,Q9UHX1,Q9NVI7,O43819,P53007 9 +Abnormal abdomen morphology 0.3505552665449928 0.2961578243260647 0.7671095560781189 1.0 1.0 205 Q9HC21,P35610,Q9UJS0,P17050,Q6PGP7,Q86Y39,P54802,Q96AA3,Q9H3H5,P35670,Q96A33,Q10713,O96000,P16278,Q15437,P00846,P04062,Q9NZJ7,O43676,Q9Y6M9,Q9HC07,P07602,Q14739,O75381,Q9BT22,Q00059,Q15392,Q96CU9,P23786,P49327,P10253,Q9NVI7,Q9Y5Y5,Q13510,P28070,Q9Y619,P03886,Q9NZ08,Q9NWS8,P10619,Q8IUX1,O15118,Q8N6S5,Q14108,Q15904,P09601,Q15067,Q9NSD9,Q13043,P21964,P00374,P40855 52 +Long toe 0.3776134689698014 0.2948472620465147 0.768110560553946 1.0 1.0 9 Q9UHX1 1 +Facial diplegia 0.377348437679374 0.2935982061877514 0.7690649466584334 1.0 1.0 9 P12235 1 +Dicarboxylic aciduria 0.2953699831529942 0.2913546775337581 0.7707800736739574 1.0 1.0 24 Q9H9P8,Q16836,P53007,P23786,O75880,P40939,Q9NPF0 7 +Single transverse palmar crease 0.2849415846498503 0.289304718956362 0.7723482014477145 1.0 1.0 41 Q9Y5Y5,Q71SY5,O95202,Q9H3H5,Q9UHX1,O75381,P51812,P40855,Q8IY17 9 +Subcapsular cataract 0.3941729075120061 0.2875709475159975 0.773675186378912 1.0 1.0 7 Q9H6K4 1 +Abnormal brainstem morphology 0.2746153346374229 0.2867138632472673 0.7743314217240624 1.0 1.0 90 Q8IUX1,P17050,Q9Y6M9,O43676,O15121,O96000,Q86Y39,Q9Y320,O60313,Q6ZXV5,Q10713,O43505,O43819,P03886,Q96CU9 15 +Exercise induced muscle cramps 0.3961162794559481 0.2809525130603306 0.778746822434472 1.0 1.0 6 P53985 1 +Megaloblastic anemia 0.3887047599112509 0.2806687909569718 0.778964448127575 1.0 1.0 8 O76024,P00374 2 +Perisylvian polymicrogyria 0.4592592592592494 0.2804625804312029 0.7791226303556071 1.0 1.0 4 P34897,P42345,Q15042 3 +Tonic seizure 0.29306760471773 0.2798638201276805 0.7795819857917903 1.0 1.0 25 Q01105,P07602 2 +Renal tubular atrophy 0.4589225589225636 0.2793754669954404 0.7799566963343705 1.0 1.0 4 Q8WUM0,Q9NQH7,P57740 3 +Generalized limb muscle atrophy 0.3883164919635224 0.2789599762991223 0.780275540206792 1.0 1.0 8 O43819,Q8IY17 2 +Difficulty climbing stairs 0.3263071197978138 0.2777735821657883 0.7811861717909019 1.0 1.0 15 P12235 1 +Premature loss of teeth 0.340295451992022 0.2773354206606319 0.7815225640662007 1.0 1.0 12 P51798,O75844 2 +Bifid ribs 0.5652740672812957 0.2764544824095032 0.7821990155606913 1.0 1.0 3 O95155 1 +Abnormal paranasal sinus morphology 0.3149417811163203 0.2752055839634102 0.7831582971715954 1.0 1.0 17 P28070,Q13432,Q03518 3 +Flared metaphysis 0.3730775977995335 0.2736156032455109 0.7843800417896691 1.0 1.0 9 Q96L58,P48651,Q14739 3 +Mandibular prognathia 0.2841123679618901 0.2723912953111478 0.7853211650876637 1.0 1.0 33 Q71SY5,Q6NUK1,Q9UHX1,Q9NVI7,P16278 5 +Adrenal hyperplasia 0.4563407507673943 0.2710883095506715 0.7863231126732979 1.0 1.0 4 P16435,P10644 2 +Patellar dislocation 0.3077920316937469 0.2684503077007941 0.7883527201113751 1.0 1.0 18 Q6ZXV5,P21964,Q9NX62 3 +Abnormal blood glucose concentration 0.2701184438177896 0.2680662527581858 0.7886483218324176 1.0 1.0 86 P35610,O95470,P09622,Q86Y39,O96000,Q13423,Q16836,Q9Y6M9,O43676,Q9HCC0,Q00059,Q96CU9,P53985,P23786,O75844,P40939,Q9BV10,P03886,Q8IUX1,Q9NSD9,Q5XKP0,O75880,P22695,Q4J6C6 24 +Distal arthrogryposis 0.4549285215006932 0.2665921511268117 0.7897831994882913 1.0 1.0 4 Q96A33 1 +Positive romberg sign 0.3714653757758991 0.2661450881825811 0.7901274714455233 1.0 1.0 9 Q8IV08,Q9H6K4,P41440,P07196 4 +Abnormal 3rd finger morphology 0.5613519695249111 0.266019317728196 0.7902243315031823 1.0 1.0 3 Q71SY5 1 +Cardiomegaly 0.2830812653113235 0.2628185238201751 0.7926904573662026 1.0 1.0 33 P17050,P23786,P04062,P54802,P10253,Q14739 6 +Optic nerve hypoplasia 0.3002416333438092 0.2615641560719475 0.7936574814252952 1.0 1.0 19 P37268,Q9UHX1,Q9NVI7 3 +Abnormality of salivation 0.2805853448303207 0.2613585565067117 0.793816013675551 1.0 1.0 44 P34897,P15586,P01889,O75787,Q9NR77,Q96RL7,P35637,P55795,Q15165,P35670,P09651,Q92804,Q9UHD9,Q14739,P51812 15 +Abnormal qt interval 0.3556952870788234 0.2598251832756857 0.7949986244668625 1.0 1.0 10 Q16836,P40939,Q9H3H5 3 +Eeg with polyspike wave complexes 0.4166477489712062 0.2595655056714118 0.7951989469906882 1.0 1.0 5 Q14108 1 +Skeletal myopathy 0.4165613594274553 0.2592573267746911 0.7954367022803681 1.0 1.0 5 P21912 1 +Skin plaque 0.4165588540355004 0.2592483908500991 0.7954435964925681 1.0 1.0 5 P16615 1 +Abnormality of tibia morphology 0.3406210164470228 0.2591983099567408 0.7954822350177257 1.0 1.0 11 O95831,P16435,Q9BV10 3 +Hypermethioninemia 0.4525703489522343 0.2591432047914103 0.7955247504602276 1.0 1.0 4 Q9UJS0 1 +Abnormal urine cytology 0.2823317930691325 0.258225120322208 0.7962331719686173 1.0 1.0 32 Q14108,P21912,P09601,P04062 4 +Abnormality of the calcaneus 0.3693340586351825 0.2563323850232699 0.7976941927556436 1.0 1.0 9 Q14739,Q96DX4 2 +Abnormality of t cell physiology 0.3548227323586655 0.2555635243042048 0.7982878866042684 1.0 1.0 10 P21964,P49327 2 +Polycystic kidney dysplasia 0.3319093853759166 0.2545832654867023 0.799044985606949 1.0 1.0 13 P21964,P23786 2 +Hyperextensibility of the finger joints 0.450977216924766 0.254152955511673 0.7993773935282962 1.0 1.0 4 P51812 1 +Abnormality of hand joint mobility 0.450977216924766 0.254152955511673 0.7993773935282962 1.0 1.0 4 P51812 1 +Tremor 0.3237880497225133 0.2492044870754983 0.8032026087169715 1.0 1.0 165 O75503,Q5JRX3,Q9UJS0,O43292,Q96RL7,Q9Y4P3,Q8N2K0,P35670,P41440,O43464,Q9H3H5,Q10713,Q9NQZ5,Q6PI48,O43681,O75787,Q96DA6,P04062,P00846,Q9NZJ7,O95831,P07602,Q6PJG6,Q9H936,O43924,Q5JTZ9,Q99720,O75569,O14773,Q6DKK2,P35270,O76024,P51798,Q9H6K4,P21912,Q13510,O75027,P03886,Q5THJ4,Q9NR77,Q16637,Q14108,O60313,Q15043,P35637,Q9NW15,P54136,Q9Y3C8,P12235,Q6P4A7,Q8IY17,Q8NI60 52 +Genetic anticipation 0.5582099596231591 0.2488014980882203 0.8035143322336902 1.0 1.0 2 P54886 1 +Hypoplasia of the uterus 0.3674925269412402 0.2479129625157053 0.8042017502977958 1.0 1.0 9 P53701 1 +Abnormal lactate dehydrogenase level 0.3047506339803134 0.2479010001096209 0.8042110060814642 1.0 1.0 18 Q5JRX3,Q9UJS0,P23786,P10253,O43505 5 +Abnormality of the musculature of the thigh 0.3811443656771792 0.2477908744002452 0.8042962159596583 1.0 1.0 8 P50402,O14979,Q9BTV4,P07196 4 +Autoimmunity 0.2821643421189282 0.2435255333127961 0.8075983076388225 1.0 1.0 30 P14174,Q8IZA0,Q9H0U3,P49327,Q13043,P21964,Q96J02,Q15437 8 +Aqueductal stenosis 0.4474747474747484 0.2433030893875906 0.8077706113065586 1.0 1.0 4 Q15427,Q8WUM0,P57740 3 +Entropion 0.366044875883119 0.2413335723974148 0.8092965926980955 1.0 1.0 9 P01889,O75844,P30153 3 +Focal dystonia 0.2901048632976299 0.2413203108308843 0.8093068702225408 1.0 1.0 22 Q96L58,Q15043,P35637,Q99720,O75569,Q9NQZ5 6 +Abnormal nipple morphology 0.26986725432155 0.2409065285186366 0.8096275621131255 1.0 1.0 53 O95202,P23786,Q15067,Q6NUK1,Q96AA3,Q9H3H5,Q96A33,Q9BV10,Q9UBM7,Q8IY17,Q7LGA3 11 +Abnormality of central nervous system electrophysiology 0.3083036576560087 0.2399446359144047 0.8103731769684512 1.0 1.0 142 O75503,P13073,O43292,Q9H3H5,Q9NZ01,Q96A33,P00403,P50897,Q9UBX3,Q9NQZ5,Q71SY5,Q9NZJ7,P07602,Q5JTZ9,O75381,Q2TAA5,Q9BQE5,Q9Y5Y5,P03886,O95202,Q14108,O60313,Q15067,P21964,P40855,Q96N66 26 +Abnormal enzyme coenzyme activity 0.3297406329202416 0.239661492449202 0.8105926895615858 1.0 1.0 176 Q5JRX3,Q9UJS0,P09622,Q8N511,P41440,Q9H3H5,P35670,Q96A33,Q10713,P16278,Q15437,P22626,Q16836,P01889,Q96DA6,P04062,P00846,Q9NZJ7,Q9HC07,P07602,Q9HCC0,Q14739,Q14566,Q00059,Q2TAA5,P23786,Q96AY3,P40939,P51649,P51798,P10253,Q9BV10,O43505,Q13510,Q9Y5Y5,P28070,Q9Y619,P03886,P10619,O15118,Q15904,Q9NW15,Q15067,Q5XKP0,Q9NSD9,Q13043,O75880,P08574,P12235,P40855,P22695 51 +Eeg with generalized slow activity 0.3514276304557143 0.2391093333761647 0.8110208046801297 1.0 1.0 10 Q9H3H5 1 +Gastrointestinal inflammation 0.3090037992356156 0.2366759346982385 0.8129082059152264 1.0 1.0 17 P08183,P01889,Q6PGP7,Q13043,P49327 5 +Abnormal eating behavior 0.2965520266615518 0.2357318691044033 0.8136407387162046 1.0 1.0 19 P53007,P35610,Q9UJS0,Q4J6C6 4 +Osteoporosis 0.2582159394533463 0.2350682855442732 0.8141557335226637 1.0 1.0 60 Q9HC21,O95202,O43292,Q96AY3,Q9Y4P3,Q9HC07,Q9H3H5,Q13043,P12235,Q13510,P16278 11 +Abnormal circulating aspartate family amino acid concentration 0.381497940228452 0.2349708111982323 0.8142313883143761 1.0 1.0 7 Q9UJS0 1 +Writer s cramp 0.5518169582772641 0.233217851260224 0.8155922447051474 1.0 1.0 2 Q9H269 1 +Abnormality of thyroid physiology 0.253960535077707 0.2322494567682853 0.8163442667742979 1.0 1.0 69 Q6PGP7,O95470,Q9Y4P3,P00403,Q13423,Q96DA6,Q16531,P04066,O95155,O76024,Q07021,Q96J02,P03886,Q9Y3E5,Q8N6S5,O60313,O14654,P12235,P21964,O60566 20 +Abnormal circulating glutamine family amino acid concentration 0.3836537435390328 0.231753908403269 0.8167291581697771 1.0 1.0 6 Q9UJS0 1 +Abnormal upper limb bone morphology 0.26336364263631 0.2303812826242816 0.817795504316619 1.0 1.0 81 Q96DX4,O95202,Q9UBM7,Q96AY3,P16435,Q9Y4P3,O75844,Q9NX62,Q6NUK1,O43924,P51798,Q9UHX1,Q9BV10,Q14739,O00116,Q7LGA3,P16278 17 +Spondyloepiphyseal dysplasia 0.5501345895020291 0.2292094195094645 0.818706151747052 1.0 1.0 2 Q9NSE4 1 +Impaired smooth pursuit 0.3178211949175913 0.2267673249926746 0.8206046727099339 1.0 1.0 15 P54136,P41440,P46977,Q10713 4 +Focal myoclonic seizure 0.376140725884963 0.2265105666318536 0.8208043418009192 1.0 1.0 8 O75503,P21912 2 +Inappropriate behavior 0.2883880355284154 0.2261476200286476 0.8210866083792787 1.0 1.0 20 Q9NZJ7,P07602 2 +Aplasia hypoplasia of the uterus 0.3127577473649358 0.2260990094748085 0.8211244149696184 1.0 1.0 16 P53701,O95202 2 +Abnormality of skin pigmentation 0.2848230177939212 0.2244185053653901 0.8224316726839938 1.0 1.0 110 Q6PGP7,P00403,Q13423,Q7LGA3,Q15437,Q8IZA0,P04062,Q9NZJ7,P07602,Q14739,Q96AY3,O75844,P16615,P49327,P21912,P51648,P03886,Q8N6S5,Q06136,P53701,P21964 21 +Abnormal ureter physiology 0.2776370761619163 0.2205420602953816 0.8254490192621868 1.0 1.0 42 P16435,Q9Y4P3,Q86XL3,Q15058,Q9UHX1,P21912,Q9UBM7,Q8TAA9,P21964 9 +Decreased circulating antibody level 0.2783586483194406 0.2164698072589354 0.8286215575390155 1.0 1.0 38 P14174,Q9UJS0,Q6PGP7,Q15904,P09601,Q9H0U3,P49327,Q9BV10 8 +Abnormal blood potassium concentration 0.3465644281310058 0.2159072199804673 0.8290600691024237 1.0 1.0 10 Q13423 1 +Abnormal ilium morphology 0.2869020872761127 0.2154552755746495 0.8294123780967086 1.0 1.0 20 Q96L58,P01889,O95831,Q15436,P36776,Q8TAA9,P51812,P16278 8 +Enlarged thorax 0.3247398476333222 0.215024941705883 0.8297478726877567 1.0 1.0 13 O75844 1 +Vocal cord paralysis 0.2996863343946933 0.2142047897355243 0.8303873611014638 1.0 1.0 18 P50402,Q9NR77,Q9BTV4,O95140,P36776,P21912,P02545,Q02978 8 +Pseudoepiphyses of hand bones 0.4371625242907082 0.212352606225681 0.8318319572898616 1.0 1.0 4 O95202 1 +Pseudoepiphyses 0.4371625242907082 0.212352606225681 0.8318319572898616 1.0 1.0 4 O95202 1 +Pseudoepiphyses of the metacarpals 0.4371625242907082 0.212352606225681 0.8318319572898616 1.0 1.0 4 O95202 1 +Apraxia 0.2599159906380996 0.2123172912924747 0.8318595064346668 1.0 1.0 58 Q9NQT5,O14773,O43292,P04062,P35637,Q9Y619,O43924,Q6DKK2,Q5JTZ9,P35270,Q10713,O75648,O96008,P05067,Q7LGA3 15 +Reticulocytosis 0.3311034351763707 0.2104555963965821 0.8333121044708094 1.0 1.0 11 P49327,Q15437 2 +Abnormal csf pyruvate family amino acid concentration 0.4364163531726155 0.2101721778878737 0.83353329342072 1.0 1.0 4 P36776 1 +Aplasia hypoplasia involving the metacarpal bones 0.2849971716285395 0.2096852723311411 0.8339133209815897 1.0 1.0 24 Q96L58,Q96DX4,P16435,Q9NX62,P36776,Q14739,P51812,Q32P28 8 +Multifocal seizures 0.4011451667228008 0.2060472783563282 0.8367539807824182 1.0 1.0 5 Q9HA77,Q10471,Q96S52,Q6PJG6 4 +Vestibular dysfunction 0.2793949532024886 0.205766962637088 0.8369729489377371 1.0 1.0 29 Q9NZ08,P17050,Q15043,P06280,P41440,P49327,P21912 7 +Abnormality of vitamin a metabolism 0.4006140715455805 0.2042797406114165 0.8381349008095778 1.0 1.0 5 Q9NSD9 1 +Cerebellar vermis atrophy 0.357399555912251 0.2027914780563723 0.8392980190721611 1.0 1.0 9 Q10713 1 +Short long bone 0.2757304194259201 0.2017349565503298 0.840123933021875 1.0 1.0 31 Q96L58,Q9BXW9,P53597,Q96DX4,Q96HY6,P10644,P36776,Q9UHX1,Q9BV10,O00116,O15228,P98175,P16278,P50542,Q7RTS9 15 +Seborrheic dermatitis 0.3756289491451127 0.2013624220237999 0.8404151962513464 1.0 1.0 6 P21964 1 +Nocturnal seizures 0.5370121130551927 0.1992876992548232 0.842037700762045 1.0 1.0 2 Q9NQX3 1 +Cystic liver disease 0.4323232323232325 0.1983568472834779 0.8427658774554811 1.0 1.0 4 O15078,Q9UGP8,P14314 3 +Pancreatic cysts 0.4323232323232265 0.1983568472834611 0.8427658774554943 1.0 1.0 4 O15078,Q9NQH7,Q9Y5S9 3 +Progressive microcephaly 0.2760629036498985 0.1981637090986206 0.8429169803451537 1.0 1.0 40 Q9HC21,Q9NQT5,Q9Y487,Q15043,Q6PJG6,Q9BV10,P50897,Q9BT22 8 +Reduced subcutaneous adipose tissue 0.3692961840554167 0.1980594487262709 0.8429985515158098 1.0 1.0 8 O75844 1 +Spinal muscular atrophy 0.3562774286455924 0.1978867280932463 0.8431336882924083 1.0 1.0 9 Q13510,Q99720 2 +Metatarsus adductus 0.3214481325228495 0.1972410160415788 0.8436389348549829 1.0 1.0 13 Q96L58,Q15392,O95202,Q9UBM7 4 +Dolichocephaly 0.2824748638489959 0.1953267887091143 0.8451371265959271 1.0 1.0 25 Q9Y5Y5,O95202,Q03164,O75381,P40855,Q96J02 6 +Dysphasia 0.3076258563460838 0.194936957111809 0.8454423015589658 1.0 1.0 16 P53701 1 +Cyanosis 0.2967186897223918 0.1947805957971295 0.8455647136470321 1.0 1.0 18 O43772,O75844,Q00325,P04066,P02545,P51812,P98175,P53007 8 +Hyperreflexia 0.3521159815102861 0.1945330842315457 0.8457584930303881 1.0 1.0 223 Q9NQT5,Q5JRX3,Q8N2K0,Q53FT3,P01889,P00846,P04062,Q8NBU5,P07602,Q9H936,O14949,Q6DKK2,P35270,Q9H6K4,Q3ZCQ8,Q9Y619,P03886,O75746,Q8N183,Q5THJ4,Q9NR77,Q16625,Q5XKP0,Q9Y3C8,Q8NI60,O00400,P13073,O43464,Q9H3H5,Q6PI48,O75787,Q9NZJ7,P17900,O00483,Q14739,P50542,Q96CU9,Q9BQT8,P34897,Q5T160,Q9BXW9,O14773,Q9P0J0,Q9BSJ2,Q96RP9,P20674,P21912,O75298,Q15041,Q9NZ08,Q15043,Q9NW15,Q15067,P54136,Q96N66,O75503,Q96AA3,Q10713,Q86XL3,O75381,O75569,Q9Y320,P49327,Q9Y5Y5,O75027,O60313,O75208,P40855,Q8IY17,O75477,P17050,O43292,Q9Y4P3,Q15058,O43681,O95831,Q6PJG6,Q9HCC0,Q99720,Q2TAA5,P35637 81 +Hepatic necrosis 0.3678354686446345 0.1920902842831608 0.8476714852160945 1.0 1.0 8 Q16836,P49748,Q16134,P40939,Q9NWH9,P35222,P38117 7 +Focal cortical dysplasia 0.5336473755047219 0.1920035369099779 0.8477394349196006 1.0 1.0 2 P42345 1 +Abnormality of exocrine pancreas physiology 0.3071316794873377 0.1919718611539029 0.8477642469989397 1.0 1.0 16 Q15904,P09601,Q9UHX1 3 +Lipid accumulation in hepatocytes 0.2501011588172916 0.1919618994368856 0.8477720501876083 1.0 1.0 68 Q9UJS0,P35670,Q8N511,P22626,Q16836,O75787,O43772,Q96DA6,O95155,Q00059,P23786,Q6NUQ1,P40939,Q16822,Q9Y3E5,Q9NWS8,Q15904,Q9NSD9,Q5XKP0,O75880,Q15067,P09651,O75648,Q9BW92,O75431 25 +Thickened nuchal skin fold 0.3272642914401145 0.1913236712514667 0.8482720166541298 1.0 1.0 11 Q9Y5Y5,O75381 2 +Renal agenesis 0.2678365980744354 0.191105455243401 0.8484429737418047 1.0 1.0 51 P16435,O43924,Q86XL3,Q15058,Q9UHX1,Q8TAA9,O43819,Q7LGA3,Q15392 9 +Limb girdle muscle atrophy 0.3407423591050118 0.1887296280651544 0.8503047290313281 1.0 1.0 10 P50402,P09651,O14979,Q9BTV4 4 +Retrognathia 0.2489943795585113 0.1880340916487967 0.8508499265427631 1.0 1.0 67 P53007,Q71SY5,P37268,P04062,Q8NCH0,O75844,Q9Y619,Q6NUK1,Q9UHX1,P53701,Q7LGA3,Q15392,Q2TAA5 13 +Abnormality of skin physiology 0.2624443898766549 0.187731996294399 0.85108674677396 1.0 1.0 84 Q15800,P35670,Q96A33,P07858,P10321,Q9HCC0,P22830,Q9UBM7,Q14739,Q8NCH0,P16615,P49327,P21912,P28070,Q9NZ08,Q92542,Q06136,Q13043,P21964 19 +Abnormal anterior horn cell morphology 0.3714301222989893 0.1858904610698011 0.8525306627902758 1.0 1.0 6 Q13510 1 +Narrow iliac wing 0.3945875377949885 0.1845433766377041 0.853587201817896 1.0 1.0 5 P51812,Q15436 2 +Pollakisuria 0.5274318411309141 0.1832854271948852 0.8545740681264662 1.0 1.0 3 Q8WVX9,P54886 2 +Prenatal movement abnormality 0.264711333637234 0.1826871826012925 0.8550434733111802 1.0 1.0 53 Q9HC21,O95202,P04062,Q16637,O75844,Q9H3H5,Q70HW3,Q9UBM7,P40855,P53007 10 +Broad ribs 0.3938728635136024 0.1822425266201555 0.8553924003473397 1.0 1.0 5 P48651,P16278 2 +Abnormality of the lymph nodes 0.2751420883392962 0.1820476357031692 0.8555453425718504 1.0 1.0 30 Q13510,Q13586,Q9NZ08,P14174,Q9H0U3,P49327,P51798,Q01844,P28070 9 +Dysdiadochokinesis 0.3098916710294082 0.1806231555931141 0.8566633792876857 1.0 1.0 15 P41440,O75027,O75503 3 +Abnormality of the thyroid gland 0.2695012519774574 0.1798120583149796 0.8573001167497853 1.0 1.0 94 P42892,Q8N6S5,Q6PGP7,O95470,Q15437,O60313,Q13043,O76024,P00403,P49327,P12235,P21912,P21964,Q13423,P03886 15 +Intestinal pseudo obstruction 0.3520307478573141 0.1795378809895037 0.8575153757956389 1.0 1.0 9 P03886 1 +Childhood onset 0.274361984126275 0.1792615947230271 0.8577323013087115 1.0 1.0 35 P50402,Q9NR77,Q15904,Q9H3H5,P51649,P22830,Q8WWV3,Q14566 8 +Palpebral edema 0.5254123190844637 0.1788030813649582 0.8580923256973592 1.0 1.0 3 Q01082,P50542 2 +Cutaneous photosensitivity 0.2817029069437745 0.178144650818668 0.858609376540572 1.0 1.0 21 Q06136,Q14108,P22830,P37268 4 +Abnormal anatomic location of the heart 0.3214696297337611 0.1779632591865477 0.8587518300145167 1.0 1.0 12 O75844 1 +Prolonged partial thromboplastin time 0.3923427560209781 0.1773451571868647 0.8592372825967045 1.0 1.0 5 Q9BV10,P38435 2 +Weakness of muscles of respiration 0.273677349088742 0.1769847913015038 0.8595203357756922 1.0 1.0 33 P50402,O95831,Q15067,P10253,P12235,Q13510,P53007,P22626 8 +Dysmenorrhea 0.5252355316285449 0.1744942436025771 0.8614770543111776 1.0 1.0 2 P02545 1 +Elevated circulating growth hormone concentration 0.5252355316285446 0.1744942436025768 0.8614770543111778 1.0 1.0 2 P10644 1 +Pituitary prolactin cell adenoma 0.5252355316285446 0.1744942436025768 0.8614770543111778 1.0 1.0 2 P10644 1 +Facial erythema 0.5252355316285364 0.1744942436025604 0.8614770543111907 1.0 1.0 2 Q9H1A4 1 +Convex nasal ridge 0.2875446382323489 0.1742672996468497 0.8616553970886203 1.0 1.0 19 O75844,O95202,Q6NUK1 3 +Thick cerebral cortex 0.3911606614400132 0.1735886402433858 0.862188760250308 1.0 1.0 5 Q9UJX6,Q9Y487 2 +Macular purpura 0.3127487810285688 0.1732262370559736 0.8624736011966796 1.0 1.0 14 Q8NCH0,P38435,P04062 3 +Abnormality of the plantar skin of foot 0.2736189226207091 0.1724726441056155 0.8630659659179698 1.0 1.0 35 P42167,Q9Y487,P16615,Q06136,P21912,Q15437 6 +Attenuation of retinal blood vessels 0.3625422029399732 0.1707746531082639 0.8644009601594473 1.0 1.0 8 P38435,Q96S66 2 +Abnormality of the scrotum 0.2732093658650306 0.1706833680169736 0.8644727413111235 1.0 1.0 40 Q9UM00,Q8TCJ2,P46977,P16435,P51809,Q9NSD9,Q9Y619,Q6NUK1,O75648,Q9BV10,Q9UBM7,Q8IY17,Q7LGA3,Q9Y3E5 14 +Vertical nystagmus 0.5214796745523123 0.1702225873709714 0.864835088789917 1.0 1.0 3 Q9NW15 1 +Hyperconvex fingernails 0.3666483619823587 0.1686457879083404 0.8660752628128217 1.0 1.0 6 P51812,O95202 2 +Joint laxity 0.2498576965799031 0.1677203526818471 0.866803283877005 1.0 1.0 70 Q8NCH0,Q9Y487,Q96AY3,Q9Y4P3,Q9HC07,Q9NSD9,Q9H3H5,Q96A33,Q9UHX1,Q9Y619,P16278 11 +Hyperpigmentation of the skin 0.2521393280118955 0.1662116480873816 0.8679903931039084 1.0 1.0 73 Q8N6S5,P04062,P16615,O75844,Q06136,P53701,P21912,Q14739,P51648,Q13423,Q7LGA3,Q15437 12 +Abnormal ossification involving the femoral head and neck 0.4204305612747785 0.1654581378442949 0.8685833967991832 1.0 1.0 4 Q14739 1 +Generalized dystonia 0.5205248990578856 0.1651287415548381 0.8688426510479037 1.0 1.0 2 P82663 1 +Long eyelashes 0.2725346828394592 0.1643545904234426 0.8694520089781981 1.0 1.0 34 Q9UM00,Q03164,Q16531,Q6NUK1,Q9UHX1,P20674,Q8IY17,Q9Y619,Q4J6C6 9 +Renal cortical cysts 0.3652291105121272 0.1636063195954502 0.8700410694292748 1.0 1.0 6 Q6PGP7,Q16134,O15078,P13804,P38117 5 +Epidermoid cyst 0.5195154777927371 0.1631630391466257 0.8703900666643416 1.0 1.0 2 O60716 1 +Right ventricular hypertrophy 0.4188552188552201 0.1612639016404879 0.8718855534081742 1.0 1.0 4 Q15233,O95630,Q969Y2 3 +Eeg with focal spike waves 0.5185060565276031 0.1612118863446565 0.8719265196207706 1.0 1.0 2 Q14118 1 +Simple febrile seizure 0.518506056527594 0.161211886344639 0.8719265196207844 1.0 1.0 2 Q9UDR5 1 +Abnormality of circulating enzyme level 0.2649520343421295 0.1603736027710063 0.8725867823973399 1.0 1.0 90 Q5JRX3,O14979,Q9Y4P3,Q6ZXV5,Q9H3H5,P13473,P22626,Q16836,Q13586,O95831,Q9HC07,P53985,P23786,Q9BTV4,P40939,P10253,O43505,Q07021,P42167,P50402,Q9NWM8,Q86VD7,O75648,P12235 24 +Elevated circulating aspartate aminotransferase concentration 0.3175422070806194 0.1582233192216865 0.8742808291191304 1.0 1.0 12 Q9Y5Y5,P40939,Q15904,O75880 4 +Abnormality of the ankles 0.2715860350984955 0.1576429814939405 0.874738132679824 1.0 1.0 41 Q9NZJ7,Q96AY3,Q15043,O75844,P07602,Q9NW15,O75298 7 +Regional abnormality of skin 0.2803103194955217 0.1569392909955511 0.8752926937869803 1.0 1.0 111 Q9Y4P3,P55795,Q9H3H5,P07858,Q9UHX1,Q7LGA3,Q15437,Q71SY5,O75381,Q14739,Q9UBM7,Q8NCH0,Q96AY3,Q9Y487,P16615,P21912,Q9Y5Y5,P51812,P42167,O95202,Q6NUK1,Q06136,Q13043,P40855,Q8IY17 25 +Kyphoscoliosis 0.2622056731518577 0.1547674871024156 0.8770046238494831 1.0 1.0 53 Q96DX4,Q9NR77,Q96AY3,Q8NCH0,Q9NWM8,Q9HC07,O75844 7 +Acral ulceration 0.5131224764468426 0.1510515519896254 0.8799350497884015 1.0 1.0 2 P39210 1 +Autoamputation of digits 0.5131224764468426 0.1510515519896254 0.8799350497884015 1.0 1.0 2 P39210 1 +Fatigable weakness of bulbar muscles 0.2950264689559541 0.1495697405343264 0.8811040831356398 1.0 1.0 17 P35637,Q15165,P09651,Q92804,P50995,Q9UHD9,P43243 7 +Functional abnormality of male internal genitalia 0.2758114800996514 0.149277787735078 0.881334441696676 1.0 1.0 26 O76024,Q13423,Q9Y4P3,P04062 4 +Abnormal muscle fiber alpha dystroglycan 0.5111036339165673 0.1473481544206416 0.8828572255151046 1.0 1.0 2 Q14118 1 +Calf muscle pseudohypertrophy 0.5111036339165673 0.1473481544206416 0.8828572255151046 1.0 1.0 2 Q14118 1 +Congenital muscular dystrophy 0.5111036339165653 0.147348154420638 0.8828572255151075 1.0 1.0 2 P02545 1 +Dilatation of the ventricular cavity 0.5111036339165641 0.1473481544206354 0.8828572255151095 1.0 1.0 2 P27635 1 +Abnormality of the nasal tip 0.2616058122093443 0.1469181987329275 0.8831965872847793 1.0 1.0 87 P42892,Q71SY5,P23786,O43292,Q03164,Q9Y487,O95831,P16435,O75844,O43924,Q96A33,Q9UHX1,P21964,P51812,Q7LGA3,P16278 16 +Agitation 0.2707156769368501 0.1449027157785536 0.8847876821873355 1.0 1.0 36 P42892,P35610,P04062,P35637,Q15165,Q6PJG6,Q92804,Q9UHD9,P05067,O96008 10 +Chordee 0.3598367921466144 0.1447971285641356 0.8848710494072305 1.0 1.0 6 P16435,P53701 2 +Neoplasm of the male external genitalia 0.355758690638711 0.1442083690435451 0.8853359324844186 1.0 1.0 8 P51809,Q13423,Q01844 3 +Plagiocephaly 0.2720762185042334 0.1441318222235778 0.8853963765691408 1.0 1.0 29 Q96A33,Q01105,Q9BV10 3 +Curly hair 0.3426986215637393 0.1404563103018792 0.8882994695582407 1.0 1.0 9 Q96A33,Q6PGP7 2 +Microscopic hematuria 0.5065634466509392 0.1394784583831074 0.8890720772610967 1.0 1.0 3 Q9BW27,Q03252 2 +Elevated circulating follicle stimulating hormone level 0.4102766746073929 0.1391143726252648 0.8893597709501937 1.0 1.0 4 P51809,P16435 2 +Gliosis 0.2698363778044012 0.138591576129026 0.8897729003422095 1.0 1.0 40 Q9H9P8,P00846,P04062,P35637,Q6PJG6,Q10713,O43819 7 +Melanoma 0.3023665917209345 0.1383468748602126 0.8899662808783104 1.0 1.0 15 Q15437 1 +Hydroxyprolinuria 0.5060565275908528 0.1383440701283806 0.8899684974170288 1.0 1.0 2 P30038 1 +Abnormality of the adrenal glands 0.2645610622937885 0.1346970217311191 0.8928514280449855 1.0 1.0 49 Q9Y5Y5,O95470,O75844,P40855,P21912,O75381,Q13423 7 +Abnormal cartilage morphology 0.3094515198503359 0.1346417932333996 0.8928950962300184 1.0 1.0 13 Q9UHX1 1 +Aplasia hypoplasia involving bones of the feet 0.2563352812408611 0.1334598473609805 0.8938297173077454 1.0 1.0 56 P13073,Q96DX4,O95202,Q03164,Q9NX62,Q96A33,Q9UHX1,Q13510,Q7LGA3 9 +Upper extremity joint dislocation 0.3004593271020921 0.1278840697793856 0.8982407179990637 1.0 1.0 15 Q9Y619 1 +Increased serum iron 0.4998083970126825 0.1265046336550543 0.899332481388941 1.0 1.0 3 Q6PGP7 1 +Cavum septum pellucidum 0.3105878709717928 0.1242091811731271 0.9011496530103104 1.0 1.0 12 Q9BV10,O95202 2 +Recurrent viral infections 0.3103874529452985 0.1232474367545517 0.901911162778942 1.0 1.0 12 Q13043,Q13432 2 +Vertigo 0.2734945812260788 0.1230311599035238 0.902082423367589 1.0 1.0 24 P06280,P49327,Q9NZ08,P21912 4 +Undetectable visual evoked potentials 0.4966352624495346 0.1225052907489169 0.9024988561424668 1.0 1.0 2 Q8TC12 1 +Adrenal overactivity 0.4033670033670017 0.1221371649463655 0.902790388829938 1.0 1.0 4 P04637,P17612,P10644 3 +Retinal atrophy 0.2731835198568801 0.1180316518271798 0.9060425786371666 1.0 1.0 22 P51648,Q10713,P04062 3 +Oral ulcer 0.3504510429175359 0.1174409138171666 0.9065106638399234 1.0 1.0 7 Q9NZ08,P49327 2 +Rhinitis 0.3503862061991285 0.1172143330032467 0.906690209120442 1.0 1.0 7 Q9BV10 1 +Abnormality of lower limb epiphysis morphology 0.3021078088347938 0.1164606953917709 0.9072874346137064 1.0 1.0 14 Q96L58,Q96DX4,O95831,Q7LGA3,P50542 5 +Macrocephaly at birth 0.4919246298788823 0.1150558412773224 0.9084008609407772 1.0 1.0 2 Q8NCE2 1 +Abnormality of the lymphatic system 0.2903449084252336 0.1142382162839035 0.9090489579803028 1.0 1.0 130 Q9UJS0,Q6PGP7,P54802,P35670,Q9H0U3,Q96A33,Q10713,P16278,Q15437,Q96DX4,P04062,Q9NZJ7,P07602,Q14739,Q9BT22,Q15392,P14174,P49327,P51798,P10253,Q13510,P28070,Q9NZ08,P10619,O15118,O95202,Q14108,Q15904,Q13043,P21964 30 +Short nose 0.2590456684523113 0.1141916363967113 0.9090858817299252 1.0 1.0 87 P42892,Q96DX4,P04062,Q9H490,Q8NCH0,Q9Y487,Q03164,Q9Y4P3,O75844,Q9NX62,Q6NUK1,Q9UHX1,P38435,Q15392,Q9NVI7 15 +Phocomelia 0.4912516823687787 0.1140170270141767 0.9092242958589244 1.0 1.0 2 Q9Y5S9 1 +Abnormal number of incisors 0.3993265993265908 0.1125731282484593 0.9103689901486268 1.0 1.0 4 A5YKK6,P38919,Q14683 3 +Spontaneous abortion 0.4920902053180549 0.112411577835589 0.9104970757280147 1.0 1.0 3 Q9NQX3,Q8NCE2 2 +Aspiration 0.3349885559288139 0.1095361369121557 0.9127772610830812 1.0 1.0 9 P17900 1 +Cholestatic liver disease 0.3976169801575889 0.1086078083141381 0.9135135672552864 1.0 1.0 4 Q9UBM7 1 +Abnormal morphology of the abdominal musculature 0.3459564971183271 0.107398641416934 0.9144727322661216 1.0 1.0 8 Q8NCH0 1 +Craniofacial hyperostosis 0.3485625587181428 0.1072663187537683 0.9145777040798848 1.0 1.0 6 Q96L58,P51812 2 +Abnormal renal insterstitial morphology 0.3069881005628485 0.1070987055649737 0.9147106740717624 1.0 1.0 12 P23786 1 +Emg myopathic abnormalities 0.2685665825544633 0.1064222039439858 0.915247376913982 1.0 1.0 28 P50402,Q13586,P51114,P07196,Q9BTV4,P13473,P12235,P53007,P22626 9 +Poikiloderma 0.3966329966329973 0.1063476196532725 0.9153065507613696 1.0 1.0 4 O75431,P18074,Q9H1A4 3 +Atonic seizure 0.2714548198898048 0.1060017707291677 0.915580947264931 1.0 1.0 22 Q01105 1 +Abnormality of the pancreas 0.2409908058557532 0.1051112464499919 0.9162875353648388 1.0 1.0 65 Q9NZ08,P01889,P14174,Q9UJS0,Q6PGP7,P53985,Q15904,P09601,Q13043,P49327,P00403,Q01844,Q9UHX1,Q14739,P03886 15 +Abnormality of the anus 0.2657467407902829 0.1041116546766758 0.9170807420282934 1.0 1.0 34 Q9BXW9,P48651,P16435,P16615,Q16531,Q6NUK1,P36776,P53701,O95155,Q8TAA9,P38646,P21964 12 +Physical urticaria 0.4845222072678476 0.103975412396997 0.9171888608569034 1.0 1.0 2 Q6P1M0 1 +Elevated circulating glutaric acid concentration 0.3674637925227335 0.1034718297604022 0.9175885060615544 1.0 1.0 5 Q16134,Q92947,P38117,Q96DA6 4 +Abnormal subarachnoid space morphology 0.2656970274919307 0.1020751255324749 0.9186970448169568 1.0 1.0 30 Q01105,O95831,P00403,Q9BV10,P03886,Q2TAA5 6 +Pseudobulbar signs 0.3208835530668668 0.1014846193874304 0.919165766470892 1.0 1.0 10 P17900 1 +Vasculitis 0.3454404460243983 0.1001821002349152 0.9201997564587558 1.0 1.0 7 Q9NZ08,P49327 2 +Aphthous ulcer 0.3453643512534169 0.0999239614211108 0.9204046930905904 1.0 1.0 7 Q9NZ08,P49327 2 +Abnormal oral mucosa morphology 0.2560053209809789 0.0998193995524169 0.9204877063553788 1.0 1.0 54 Q9NZ08,P17050,P04062,Q14108,Q9Y4P3,P49327,Q15392,Q14739,P16278 9 +Microretrognathia 0.2985342029273604 0.0981138085717624 0.9218419227762378 1.0 1.0 14 Q9UHX1 1 +Premature skin wrinkling 0.2906011297510593 0.0967883068004804 0.9228945101552636 1.0 1.0 16 Q9Y487,O75844 2 +Motor polyneuropathy 0.3070696982095587 0.0963699817117546 0.9232267322578886 1.0 1.0 11 Q15041,O43819 2 +Abnormal systemic arterial morphology 0.282633418639623 0.0960213481330951 0.9235036175443556 1.0 1.0 121 Q6ZXV5,Q9UHX1,Q7LGA3,P16278,P00846,P04062,Q9NZJ7,P07602,P17900,P38435,O75844,P10253,P21912,Q13510,P03886,P10619,O15118,Q8N6S5,Q9NWM8,Q9NSD9,Q6NUK1,P53701,P21964 23 +Abnormal b cell subset distribution 0.4784656796769999 0.0954712932964469 0.9239404907178568 1.0 1.0 2 P17812 1 +Exaggerated cupid s bow 0.3437815975733007 0.0945819944490409 0.9246468520606264 1.0 1.0 7 Q969N2,Q71SY5,P61978,Q00839,P11233,Q6DKJ4 6 +Respiratory failure requiring assisted ventilation 0.3640835728724801 0.0943097505140612 0.9248631046494225 1.0 1.0 5 P10253 1 +Abnormality of the musculature of the upper limbs 0.242505632042404 0.0935893097674143 0.9254354019093952 1.0 1.0 68 Q9BQT8,P50402,Q9NR77,Q9NZJ7,Q9Y487,O14979,P07602,Q9H3H5,P12235 9 +Increased laxity of ankles 0.475773889636613 0.0918517394550621 0.926815835629851 1.0 1.0 2 O95140 1 +Localized osteoporosis 0.4747644683714731 0.0905195614772442 0.9278743499527008 1.0 1.0 2 P57740 1 +Congenital malformation of the right heart 0.3421805860825123 0.0892316572585016 0.9288978068649628 1.0 1.0 7 P40855,P01889 2 +Anal atresia 0.2742461361047251 0.0883030983718305 0.9296357764330572 1.0 1.0 19 P21964,P53701 2 +Fatigable weakness of respiratory muscles 0.2888292432128764 0.0870853031263122 0.9306037074068084 1.0 1.0 16 P35637,Q15165,P09651,Q92804,P50995,Q9UHD9,P43243 7 +Abnormal urine hormone level 0.4720726783310904 0.0870337160710015 0.9306447122318238 1.0 1.0 2 P10644 1 +Increased urinary cortisol level 0.4720726783310904 0.0870337160710015 0.9306447122318238 1.0 1.0 2 P10644 1 +Short chin 0.3165075008080317 0.0835037476673188 0.9334509975942112 1.0 1.0 10 O75844 1 +Metaphyseal widening 0.278505826755865 0.0815331061285288 0.9350179976284172 1.0 1.0 18 Q96L58,P48651,O95831,Q14739,P16278 5 +Spina bifida 0.2617894918689855 0.0810710135624991 0.9353854776140966 1.0 1.0 31 Q9HC21,Q10713,Q9UHX1,P21964,Q8TAA9 5 +Progressive muscle weakness 0.3035895938676191 0.0810641047705628 0.9353909719485776 1.0 1.0 11 Q9Y5Y5,O75381 2 +Abnormality of dental color 0.4726239542130167 0.0803313100430882 0.9359737568595616 1.0 1.0 3 P16278 1 +Chronic otitis media 0.2677069548190168 0.0801927935363925 0.9360839216289436 1.0 1.0 23 P21964,Q03518,O95202 3 +Adrenocortical carcinoma 0.4722315718613226 0.0797354391187367 0.9364476728335258 1.0 1.0 3 P42771,P10644 2 +Ependymoma 0.4722315718613044 0.0797354391187093 0.9364476728335476 1.0 1.0 3 P42771,O75874 2 +Abnormality of skeletal muscle fiber size 0.282565943274952 0.0768893798204206 0.938711546211465 1.0 1.0 17 Q13586,O60313,O95831,O00483,P09651,Q9BPX6,P02545,P22626 8 +Bone fracture 0.3382963017596981 0.0764764655637851 0.9390400368912004 1.0 1.0 7 Q13126 1 +Hand tremor 0.3145213825278469 0.0755022053709115 0.9398151429150188 1.0 1.0 10 O95140,P07196,O94905,Q16637 4 +Athetosis 0.2939845397810267 0.0753141336039152 0.9399647764312168 1.0 1.0 14 O14949 1 +Dilation of virchow robin spaces 0.4613055181695987 0.0740432082080305 0.9409760044189696 1.0 1.0 2 P27635 1 +Telecanthus 0.2613830266430572 0.0733489846482308 0.9415284125334776 1.0 1.0 32 Q9H490,Q03164,Q8NCH0,O75844,Q86XL3,P21964 6 +J shaped sella turcica 0.4586137281292101 0.0710288606407876 0.9433747860237204 1.0 1.0 2 O75431 1 +Disproportionate tall stature 0.2659023443917018 0.0697004741133478 0.9444320644135262 1.0 1.0 21 Q8NCH0,Q9NWM8,Q7LGA3,O95202 4 +Abnormality of the calf musculature 0.2894565058540413 0.0696854440948142 0.9444440275448418 1.0 1.0 15 Q12768,Q9NR77,Q96RL7,P02545,P53007,Q9NRG9 6 +Gaze evoked nystagmus 0.3351791690494476 0.0692266054373999 0.9448092458270588 1.0 1.0 8 Q10713 1 +Lymphedema 0.2958562859781594 0.068389388283328 0.9454756689764608 1.0 1.0 13 Q14739,P06280 2 +Intellectual disability mild 0.2760340179483099 0.0668105448062777 0.9467325286265224 1.0 1.0 115 P35610,Q6PGP7,P17050,O43292,Q15800,Q9NZ01,Q10713,Q8WWV3,Q7LGA3,P16278,Q01105,P00846,Q96DX4,Q9BT22,P16615,Q15904,Q9NW15,Q6NUK1,P54136,P21964,Q8IY17,Q96N66 22 +Polyphagia 0.3353358359917282 0.0665091576438329 0.9469724671091037 1.0 1.0 6 Q4J6C6 1 +Emotional lability 0.2540803455261298 0.066198284342106 0.9472199626770172 1.0 1.0 53 Q8N183,O43681,Q96RL7,Q9NZJ7,Q9P0J0,P35637,Q15165,P07602,O00483,Q92804,Q9UHD9,Q96CU9 12 +Hyporeflexia of lower limbs 0.2999266375132947 0.0653181462256154 0.9479206945975144 1.0 1.0 11 Q13586,P40939,Q9NR77 3 +Abnormal nervous system electrophysiology 0.3147094781051176 0.0642676840312787 0.9487570846481534 1.0 1.0 174 O15269,O75503,P13073,O43292,Q9H3H5,Q9NZ01,Q96A33,P00403,P50897,Q9UBX3,Q9NQZ5,O43681,Q71SY5,Q9NZJ7,O95831,P07602,Q5JTZ9,Q99720,O75381,Q2TAA5,O14773,Q9BQE5,Q9Y5Y5,Q9Y619,P03886,O95202,Q9NR77,Q14108,O15121,O60313,Q15067,P21964,P40855,Q96N66 34 +Thick eyebrow 0.2617994694667231 0.0633807653712497 0.9494633034623904 1.0 1.0 39 P15586,Q9UM00,Q96EK5,Q03164,O95831,Q9BSJ2,Q16531,Q6NUK1,P51812,Q9UHX1,P04066,Q9Y4W2,O94905,Q9NZN8 14 +Axonal loss 0.351894139054842 0.0630931574214152 0.9496923230315452 1.0 1.0 5 P41440,Q9UHD9 2 +Primitive reflex 0.3336853171173221 0.0617568315799664 0.950756481239919 1.0 1.0 7 P17900 1 +Periventricular cysts 0.3336440735288744 0.061561888177692 0.9509117281750536 1.0 1.0 6 O95202 1 +Prematurely aged appearance 0.2610913241257749 0.0612919617780709 0.9511266923397956 1.0 1.0 35 Q9Y487,O75844,Q6NUK1,P49327,Q13126 5 +Deformed sella turcica 0.4587680915516493 0.0604887012184373 0.9517664144942216 1.0 1.0 3 O75431,Q7RTS9 2 +Chondrocalcinosis 0.3745814906501269 0.0599775913452724 0.9521734820692304 1.0 1.0 4 P35670 1 +Ventricular escape rhythm 0.3504963687065867 0.0596986200838526 0.952395670790272 1.0 1.0 5 P50402,Q9BTV4 2 +Abnormality of the fetal cardiovascular system 0.3727296837183508 0.0564593433018471 0.9549758831796916 1.0 1.0 4 P16435 1 +Abnormality of dental structure 0.2379663701565743 0.056441584945231 0.954990029740191 1.0 1.0 66 Q96L58,Q13586,P48651,Q96AY3,Q9Y487,Q9Y4P3,Q15436,Q9HC07,O75844,P51798,P53701,Q9UBM7,P51648,Q6P4Q7,P21964,P16278 16 +Poor fine motor coordination 0.3490046772765296 0.0561184487669964 0.9552474471066594 1.0 1.0 5 O95140,Q6PI48 2 +Skeletal muscle atrophy 0.300213666488267 0.054713967981426 0.9563663411925724 1.0 1.0 152 O15269,Q9NQT5,O00400,Q9HC21,P17050,O14979,Q8N2K0,Q92804,P13473,Q13126,P16278,P22626,Q13586,Q71SY5,Q96DA6,O95831,P51970,Q15165,Q9HCC0,Q9UHD9,Q99720,Q9BQT8,Q9BTV4,Q6DKK2,P21912,O43505,Q13510,O43819,O75298,Q9NVI7,P51812,P50402,Q9NR77,Q16637,O60313,Q9NWM8,P35637,Q13043,P12235,Q6P4A7,Q8IY17,P53007,O75477 43 +Nephronophthisis 0.3482654092286948 0.0543604300636135 0.9566480044493996 1.0 1.0 5 O15078,Q8TD19,Q96EX3,Q9NQH7 4 +Gangrene 0.319701456036378 0.0522117034599168 0.9583600076417244 1.0 1.0 9 Q9NZ08,P49327 2 +Bladder neoplasm 0.3472549680026928 0.05197502937498 0.958548590185923 1.0 1.0 5 P35222,O60566,P04637,P78549 4 +Cranial hyperostosis 0.2919466713480438 0.0503556663568528 0.959838964658672 1.0 1.0 13 Q96L58,P48651,Q15043,P51812,P22626 5 +Atrophy degeneration involving the spinal cord 0.329706687776374 0.049431398741327 0.9605755061620228 1.0 1.0 7 Q8IY17,P07196 2 +Abnormally folded helix 0.288479958015358 0.048604098514444 0.9612348036852928 1.0 1.0 14 P21964 1 +Ethylmalonic aciduria 0.3673400673400679 0.0465514316578105 0.9628707419528604 1.0 1.0 4 Q16134,P53597,P38117 3 +Hepatic cysts 0.4320323014804899 0.045961539842825 0.9633409042542996 1.0 1.0 2 Q9UGP8 1 +Hypoplasia of the ear cartilage 0.4473241332884528 0.0459290728830284 0.9633667818124474 1.0 1.0 3 Q8WUM0,P57740 2 +Amblyopia 0.2846660550358532 0.0455737098641543 0.9636500238823108 1.0 1.0 15 Q9UHX1 1 +Heinz bodies 0.4300134589502077 0.0443859323383322 0.964596774965691 1.0 1.0 2 O14936 1 +Brachydactyly 0.2352397021285804 0.042443048983784 0.9661455111235132 1.0 1.0 64 Q96DX4,Q9UBM7,O95831,P16435,Q9NX62,O43924,Q06136,Q9UHX1,P21912,Q14739,Q8IY17,Q15437 12 +Back pain 0.2621043550392868 0.0420391984800839 0.9664674498552844 1.0 1.0 23 P50402,P01889,Q9BTV4,P35670,P51798,Q8TAA9 6 +Abnormality of the lens 0.3185367910849417 0.03827150356989 0.9694712109915766 1.0 1.0 184 Q53H12,O00400,Q9UJS0,P17050,Q15800,O14979,Q9Y4P3,Q8N2K0,Q6ZXV5,Q9H3H5,P00403,Q10713,Q8WWV3,Q13126,Q7LGA3,Q03518,Q15437,P22626,P01889,Q71SY5,Q15436,O75381,Q9UBM7,P23786,P06280,O76024,P49327,Q9H6K4,P21912,O43505,Q9NVI7,Q9Y5Y5,P08670,P51812,P03886,Q9NZ08,O60313,Q9NW15,P04439,Q06136,Q99797,P12235,P53701,P21964,P40855,Q8IY17 46 +Dry hair 0.4209286675639275 0.0378220086458096 0.9698295965632217 1.0 1.0 2 Q9Y276 1 +Abnormality of the common coagulation pathway 0.2932480978166756 0.0376058601060912 0.9700019355395932 1.0 1.0 11 Q9BV10,P38435 2 +Micropenis 0.246425091639703 0.037150522992297 0.9703649882851152 1.0 1.0 57 P42892,P46977,O95470,P16435,Q6NUK1,Q10713,Q9BV10,Q9NVI7,O43505,P53701,Q9Y619,Q8IY17 12 +Urinary incontinence 0.2584178968774215 0.0345864537671297 0.9724095033660358 1.0 1.0 41 O43681,Q9NZJ7,P07602,Q99720,Q8TAA9,P51812,O75298 7 +Adrenocortical abnormality 0.4145356662180325 0.0336961454683477 0.9731194526994248 1.0 1.0 2 P10644 1 +Primary hypercortisolism 0.4145356662180325 0.0336961454683477 0.9731194526994248 1.0 1.0 2 P10644 1 +Increased muscle fatiguability 0.4364378244228575 0.0335640040652553 0.9732248266798332 1.0 1.0 3 P53985 1 +Overlapping fingers 0.3240977710656372 0.0326586660638267 0.973946785996502 1.0 1.0 7 Q9BV10 1 +Abnormality of the metaphysis 0.2558830243575846 0.0320786882671855 0.9744092989614492 1.0 1.0 47 Q96L58,P48651,Q96DX4,O95831,Q9HC07,Q96HY6,P36776,P51798,Q13126,Q9UG56,P16278,Q14739 12 +Diffuse mesangial sclerosis 0.2847117293131659 0.0308961374569459 0.9753523703170552 1.0 1.0 14 O95470,Q92621,P57740,Q8N1F7 4 +Premature osteoarthritis 0.4094885598923318 0.0307104862619502 0.975500428280403 1.0 1.0 2 Q96HY6 1 +Abnormally shaped carpal bones 0.4094885598923262 0.0307104862619468 0.9755004282804056 1.0 1.0 2 Q7RTS9 1 +Abnormality of the gingiva 0.2578024251392988 0.0306911076283869 0.9755158829079218 1.0 1.0 42 P04062,Q14108,Q9Y4P3,Q14739,P16278,Q15392 6 +Aplasia hypoplasia of the nipples 0.2814564794888506 0.0298625402304712 0.9761766810817498 1.0 1.0 15 Q96A33,O95202 2 +Tongue atrophy 0.4324369219424814 0.0293722175944557 0.976567730389204 1.0 1.0 3 Q9NQT5 1 +Pituitary growth hormone cell adenoma 0.4321777179400838 0.0291070479772831 0.976779214707888 1.0 1.0 3 O00170,P10644 2 +Polycystic liver disease 0.4321777179400776 0.0291070479772767 0.9767792147078932 1.0 1.0 3 Q9UGP8,P14314 2 +Hemoglobinuria 0.4301581958936215 0.0270674726242071 0.9784059183357734 1.0 1.0 3 Q969N2,O14936 2 +Proptosis 0.2557465518803266 0.0253500536131971 0.979775749731908 1.0 1.0 46 Q6PGP7,Q96DX4,O95202,P16435,Q15043,Q9NX62,O75844,Q6NUK1,Q9UBM7,O75718 10 +Glomerular deposits 0.4278020868394468 0.0247467425004962 0.980256971358538 1.0 1.0 3 P52429,P57740 2 +Aplasia hypoplasia of the optic nerve 0.2589601650413074 0.0227266008673212 0.981868356889273 1.0 1.0 22 P37268,Q9UHX1,Q9NVI7 3 +Decreased activity of the pyruvate dehydrogenase complex 0.2725126368769282 0.022237074415007 0.9822588437888236 1.0 1.0 17 Q8N183,Q9P0J0,P11177,Q96CU9 4 +Femoral bowing 0.3005270679837857 0.0220812275243539 0.9823831610912156 1.0 1.0 10 P16435,Q96DX4 2 +Abnormal muscle fiber protein expression 0.320244025249179 0.0215506702656842 0.9828063838061992 1.0 1.0 7 P50402,Q9BTV4 2 +Sclerosis of skull base 0.4242341351495389 0.0213513262128693 0.9829654007583022 1.0 1.0 3 Q14739 1 +Vertebral arch anomaly 0.4228114164391486 0.0200368738538833 0.9840139573819656 1.0 1.0 3 Q96HY6 1 +Narrow vertebral interpedicular distance 0.4228114164391486 0.0200368738538833 0.9840139573819656 1.0 1.0 3 Q96HY6 1 +Retinal fold 0.3792059219380868 0.0172016286108049 0.9862757629386478 1.0 1.0 2 P52732 1 +Neonatal onset 0.2569854577875284 0.0167435141275114 0.9866412327648476 1.0 1.0 20 P34897,O75787,Q9H490,Q15904,P40939 5 +Eversion of lateral third of lower eyelids 0.3765141318977078 0.0163187338785042 0.9869801120574156 1.0 1.0 2 P61978 1 +Lower extremity joint dislocation 0.2354936101222807 0.015597448850866 0.9875555409582116 1.0 1.0 67 Q9NQT5,O95202,Q9Y487,Q9Y4P3,Q9NX62,O75844,Q6ZXV5,Q96A33,Q9UHX1,Q9UBM7,P21964,P53007 12 +Dyslexia 0.2984929554343112 0.0147644364903252 0.9882201120571537 1.0 1.0 10 Q13586,Q9H6K4 2 +Abnormal gastrointestinal motility 0.2578219165331823 0.013884720136072 0.98892195212125 1.0 1.0 25 P35637,P06280,O76024,P00403,Q9UBM7,P03886 6 +Increased circulating cortisol level 0.4146751935375256 0.0129420197320899 0.989674050529954 1.0 1.0 3 P04637,P10644 2 +Impairment of activities of daily living 0.2499039856521198 0.0115721301973457 0.9907669820524284 1.0 1.0 52 O15269,O43681,Q9NZJ7,P07602,Q99720,P21964,Q8TAA9,P51812,O75298 9 +Distal lower limb muscle weakness 0.2703880773567755 0.0111861821557514 0.991074904097859 1.0 1.0 17 P00846 1 +Multiple joint dislocation 0.4096263884213937 0.0088907259110433 0.992906320514696 1.0 1.0 3 Q96L58,Q9Y2D4 2 +Uterus didelphys 0.3378196500672962 0.0078243260157662 0.9937571547713084 1.0 1.0 2 Q96EX3 1 +Thenar muscle atrophy 0.3361372812920608 0.0075974600650062 0.9939381622291644 1.0 1.0 2 Q15120 1 +Aplasia hypoplasia affecting the fundus 0.2568950160230795 0.0075762485850189 0.99395508605448 1.0 1.0 25 Q15058,P37268,Q9UHX1,Q9NVI7 4 +Hyperostosis 0.2787166440028983 0.0037325573005035 0.9970218570728576 1.0 1.0 14 Q96L58,P48651,Q15043,P51812,P22626 5 +Neonatal alloimmune thrombocytopenia 0.4022214742510905 0.0034148204522431 0.9972753727785548 1.0 1.0 3 Q9Y3Z3,O75792 2 +Moyamoya phenomenon 0.4022214742510905 0.0034148204522431 0.9972753727785548 1.0 1.0 3 Q9Y3Z3,O75792 2 +Chilblains 0.4022214742510905 0.0034148204522431 0.9972753727785548 1.0 1.0 3 Q9Y3Z3,O75792 2 +Csf lymphocytic pleiocytosis 0.4022214742510905 0.0034148204522431 0.9972753727785548 1.0 1.0 3 Q9Y3Z3,O75792 2 +Chronic leukemia 0.4022214742510905 0.0034148204522431 0.9972753727785548 1.0 1.0 3 Q9Y3Z3,O75792 2 +Degeneration of the striatum 0.4022214742510905 0.0034148204522431 0.9972753727785548 1.0 1.0 3 Q9Y3Z3,O75792 2 +Chronic lymphatic leukemia 0.4022214742510905 0.0034148204522431 0.9972753727785548 1.0 1.0 3 Q9Y3Z3,O75792 2 +Porencephalic cyst 0.4022214742510905 0.0034148204522431 0.9972753727785548 1.0 1.0 3 Q9Y3Z3,O75792 2 +Csf pleocytosis 0.4022214742510905 0.0034148204522431 0.9972753727785548 1.0 1.0 3 Q9Y3Z3,O75792 2 +Skin tags 0.2645145653414364 0.0027039970703557 0.9978425251142062 1.0 1.0 18 Q9UHX1 1 +Hypoplastic nipples 0.2950301972738705 0.0025800734580741 0.9979414015060049 1.0 1.0 10 Q96A33 1 +Solitary median maxillary central incisor 0.3991921911814104 0.0013288208732329 0.9989397546531988 1.0 1.0 3 A5YKK6,Q14683 2 +Osteomyelitis 0.2780869586888814 0.0009533665957826 0.9992393236276708 1.0 1.0 14 O15269,Q13126 2 +Limb undergrowth 0.2535418563400686 0.0002394763092068 0.9998089255520322 1.0 1.0 45 Q8N6S5,Q9UBM7,Q03164,Q9UHX1,Q9BV10,Q14739,O75718,Q15392 8 +Bronchiectasis 0.2719261907489987 7.729958489190294e-05 0.9999383238547196 1.0 1.0 16 Q13432 1 diff --git a/msigdb_hp/selections.json b/msigdb_hp/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..0f8d30df0b31563b2b172ab25b6d8b070ef8e15b --- /dev/null +++ b/msigdb_hp/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["11 pairs of ribs", "2 3 finger syndactyly", "2 3 toe cutaneous syndactyly", "2 3 toe syndactyly", "3 4 finger syndactyly", "3 methylglutaconic aciduria", "4 5 toe syndactyly", "Abdominal aortic aneurysm", "Abdominal distention", "Abdominal obesity", "Abdominal pain", "Abdominal wall muscle weakness", "Abducens palsy", "Abnormal 2nd finger morphology", "Abnormal 3rd finger morphology", "Abnormal 5th finger morphology", "Abnormal 5th finger phalanx morphology", "Abnormal abdomen morphology", "Abnormal acetabulum morphology", "Abnormal activity of mitochondrial respiratory chain", "Abnormal adipose tissue morphology", "Abnormal aggressive impulsive or violent behavior", "Abnormal aldolase level", "Abnormal anatomic location of the heart", "Abnormal anterior chamber morphology", "Abnormal anterior eye segment morphology", "Abnormal anterior horn cell morphology", "Abnormal aortic arch morphology", "Abnormal aortic morphology", "Abnormal aortic valve cusp morphology", "Abnormal aortic valve morphology", "Abnormal aortic valve physiology", "Abnormal arachnoid mater morphology", "Abnormal arm span", "Abnormal arterial physiology", "Abnormal astrocyte morphology", "Abnormal atrial arrangement", "Abnormal atrioventricular conduction", "Abnormal atrioventricular valve morphology", "Abnormal atrioventricular valve physiology", "Abnormal auditory evoked potentials", "Abnormal autonomic nervous system physiology", "Abnormal b cell morphology", "Abnormal b cell subset distribution", "Abnormal basal ganglia mri signal intensity", "Abnormal biliary tract morphology", "Abnormal bleeding", "Abnormal blistering of the skin", "Abnormal blood carbon dioxide level", "Abnormal blood chloride concentration", "Abnormal blood gas level", "Abnormal blood glucose concentration", "Abnormal blood inorganic cation concentration", "Abnormal blood ion concentration", "Abnormal blood monovalent inorganic cation concentration", "Abnormal blood phosphate concentration", "Abnormal blood potassium concentration", "Abnormal blood sodium concentration", "Abnormal blood transition element cation concentration", "Abnormal blood zinc concentration", "Abnormal bone structure", "Abnormal bowel sounds", "Abnormal brain choline level by mrs", "Abnormal brain lactate level by mrs", "Abnormal brain n acetyl aspartate level by mrs", "Abnormal brain positron emission tomography", "Abnormal brainstem morphology", "Abnormal brainstem mri signal intensity", "Abnormal branching pattern of the aortic arch", "Abnormal breath sound", "Abnormal bronchoalveolar lavage fluid morphology", "Abnormal bronchus morphology", "Abnormal bronchus physiology", "Abnormal c peptide level", "Abnormal c reactive protein level", "Abnormal calcium phosphate regulating hormone level", "Abnormal cardiac atrium morphology", "Abnormal cardiac exercise stress test", "Abnormal cardiac septum morphology", "Abnormal cardiac test", "Abnormal cardiac ventricle morphology", "Abnormal cardiac ventricular function", "Abnormal cardiomyocyte morphology", "Abnormal carotid artery morphology", "Abnormal cartilage morphology", "Abnormal caudate nucleus morphology", "Abnormal cd4 cd8 ratio", "Abnormal cell morphology", "Abnormal cell proliferation", "Abnormal cellular composition of bronchoalveolar fluid", "Abnormal cellular phenotype", "Abnormal central sensory function", "Abnormal cerebellar vermis morphology", "Abnormal cerebral artery morphology", "Abnormal cerebral cortex morphology", "Abnormal cerebral vascular morphology", "Abnormal cerebral vein morphology", "Abnormal cerebral ventricle morphology", "Abnormal cerebrospinal fluid metabolite concentration", "Abnormal cervical curvature", "Abnormal cervical spine morphology", "Abnormal chorioretinal morphology", "Abnormal choroid morphology", "Abnormal choroid plexus morphology", "Abnormal chromosome morphology", "Abnormal ciliary body morphology", "Abnormal circulating acetylcarnitine concentration", "Abnormal circulating albumin concentration", "Abnormal circulating amino acid concentration", "Abnormal circulating amylase level", "Abnormal circulating androgen level", "Abnormal circulating apolipoprotein concentration", "Abnormal circulating arginine concentration", "Abnormal circulating aromatic amino acid concentration", "Abnormal circulating aspartate family amino acid concentration", "Abnormal circulating bilirubin concentration", "Abnormal circulating branched chain amino acid concentration", "Abnormal circulating carbohydrate concentration", "Abnormal circulating carboxylic acid concentration", "Abnormal circulating ceruloplasmin concentration", "Abnormal circulating cholesterol concentration", "Abnormal circulating citrulline concentration", "Abnormal circulating copper concentration", "Abnormal circulating creatinine concentration", "Abnormal circulating dehydroepiandrosterone concentration", "Abnormal circulating dicarboxylic acid concentration", "Abnormal circulating estrogen level", "Abnormal circulating fatty acid anion concentration", "Abnormal circulating fatty acid concentration", "Abnormal circulating ferritin concentration", "Abnormal circulating follicle stimulating hormone concentration", "Abnormal circulating free fatty acid concentration", "Abnormal circulating gaba concentration", "Abnormal circulating glutamine concentration", "Abnormal circulating glutamine family amino acid concentration", "Abnormal circulating glycine concentration", "Abnormal circulating gonadotropin concentration", "Abnormal circulating hormone concentration", "Abnormal circulating iga level", "Abnormal circulating ige level", "Abnormal circulating igg level", "Abnormal circulating igm level", "Abnormal circulating inhibin level", "Abnormal circulating lipid concentration", "Abnormal circulating long chain fatty acid concentration", "Abnormal circulating metabolite concentration", "Abnormal circulating methionine concentration", "Abnormal circulating monocarboxylic acid cocentration", "Abnormal circulating nitrogen compound concentration", "Abnormal circulating non proteinogenic amino acid concentration", "Abnormal circulating nucleobase concentration", "Abnormal circulating phenylalanine concentration", "Abnormal circulating porphyrin concentration", "Abnormal circulating progesterone level", "Abnormal circulating proline concentration", "Abnormal circulating protein concentration", "Abnormal circulating proteinogenic amino acid concentration", "Abnormal circulating proteinogenic amino acid derivative concentration", "Abnormal circulating pyruvate family amino acid concentration", "Abnormal circulating renin", "Abnormal circulating serine concentration", "Abnormal circulating serine family amino acid concentration", "Abnormal circulating sex hormone concentration", "Abnormal circulating sulfur amino acid concentration", "Abnormal circulating tyrosine concentration", "Abnormal clavicle morphology", "Abnormal cns myelination", "Abnormal cochlea morphology", "Abnormal conjugate eye movement", "Abnormal conjunctiva morphology", "Abnormal connection of the cardiac segments", "Abnormal consumption behavior", "Abnormal conus terminalis morphology", "Abnormal cornea morphology", "Abnormal corneal epithelium morphology", "Abnormal coronary artery morphology", "Abnormal corpus callosum morphology", "Abnormal corpus striatum morphology", "Abnormal cortical bone morphology", "Abnormal cortical gyration", "Abnormal cranial nerve morphology", "Abnormal cranial nerve physiology", "Abnormal cry", "Abnormal csf carboxylic acid concentration", "Abnormal csf metabolite level", "Abnormal csf protein level", "Abnormal csf pyruvate family amino acid concentration", "Abnormal cutaneous elastic fiber morphology", "Abnormal delayed hypersensitivity skin test", "Abnormal delivery", "Abnormal dense granules", "Abnormal dental pulp morphology", "Abnormal dental root morphology", "Abnormal dentate nucleus morphology", "Abnormal dentin morphology", "Abnormal dermatoglyphics", "Abnormal dermoepidermal junction morphology", "Abnormal diaphysis morphology", "Abnormal distal phalanx morphology of finger", "Abnormal dlco", "Abnormal drinking behavior", "Abnormal duodenum morphology", "Abnormal dura mater morphology", "Abnormal eating behavior", "Abnormal echocardiogram", "Abnormal elasticity of skin", "Abnormal electrophysiology of sinoatrial node origin", "Abnormal electroretinogram", "Abnormal emotion affect behavior", "Abnormal enchondral ossification", "Abnormal endocardium morphology", "Abnormal endocrine physiology", "Abnormal enzyme coenzyme activity", "Abnormal eosinophil morphology", "Abnormal epidermal morphology", "Abnormal epiglottis morphology", "Abnormal epiphyseal ossification", "Abnormal epiphysis morphology of the phalanges of the hand", "Abnormal erythrocyte enzyme level", "Abnormal erythrocyte morphology", "Abnormal erythrocyte physiology", "Abnormal erythrocyte sedimentation rate", "Abnormal esophagus morphology", "Abnormal esophagus physiology", "Abnormal external genitalia", "Abnormal exteroceptive sensation", "Abnormal eyebrow morphology", "Abnormal eyelash morphology", "Abnormal eyelid morphology", "Abnormal eyelid physiology", "Abnormal facial expression", "Abnormal facial shape", "Abnormal factor ix activity", "Abnormal fallopian tube morphology", "Abnormal fear anxiety related behavior", "Abnormal female reproductive system physiology", "Abnormal femoral head morphology", "Abnormal femoral neck head morphology", "Abnormal femoral neck morphology", "Abnormal finger phalanx morphology", "Abnormal fingernail morphology", "Abnormal fingertip morphology", "Abnormal foot bone ossification", "Abnormal foramen magnum morphology", "Abnormal forearm bone morphology", "Abnormal form of the vertebral bodies", "Abnormal foveal morphology", "Abnormal full field electroretinogram", "Abnormal fundus autofluorescence imaging", "Abnormal gallbladder morphology", "Abnormal gastrointestinal motility", "Abnormal glial cell morphology", "Abnormal globus pallidus morphology", "Abnormal glomerular basement membrane morphology", "Abnormal glomerular filtration rate", "Abnormal glomerular mesangial cellularity", "Abnormal glomerular mesangium morphology", "Abnormal glucose homeostasis", "Abnormal glycosylation", "Abnormal granulocyte count", "Abnormal granulocytopoietic cell morphology", "Abnormal greater sciatic notch morphology", "Abnormal growth hormone level", "Abnormal hair laboratory examination", "Abnormal hair morphology", "Abnormal hair pattern", "Abnormal hair quantity", "Abnormal hair whorl", "Abnormal hand bone ossification", "Abnormal hand morphology", "Abnormal hdl cholesterol concentration", "Abnormal head movements", "Abnormal heart rate variability", "Abnormal heart sound", "Abnormal heart valve morphology", "Abnormal heart valve physiology", "Abnormal hemoglobin", "Abnormal hemoglobin concentration", "Abnormal hepatic iron concentration", "Abnormal humerus morphology", "Abnormal hypothalamus morphology", "Abnormal hypothalamus physiology", "Abnormal ileum morphology", "Abnormal iliac wing morphology", "Abnormal ilium morphology", "Abnormal immune system morphology", "Abnormal incisor morphology", "Abnormal inflammatory response", "Abnormal insulin level", "Abnormal internal genitalia", "Abnormal intestine morphology", "Abnormal intraocular pressure", "Abnormal involuntary eye movements", "Abnormal iris pigmentation", "Abnormal jaw morphology", "Abnormal jejunum morphology", "Abnormal joint morphology", "Abnormal labia majora morphology", "Abnormal labia minora morphology", "Abnormal labia morphology", "Abnormal lacrimal duct morphology", "Abnormal lacrimal gland morphology", "Abnormal lactate dehydrogenase level", "Abnormal large intestine morphology", "Abnormal large intestine physiology", "Abnormal larynx morphology", "Abnormal larynx physiology", "Abnormal lateral ventricle morphology", "Abnormal ldl cholesterol concentration", "Abnormal left atrium morphology", "Abnormal left ventricle morphology", "Abnormal left ventricular outflow tract morphology", "Abnormal length of corpus callosum", "Abnormal leukocyte count", "Abnormal leukocyte physiology", "Abnormal levels of alpha fetoprotein", "Abnormal libido", "Abnormal light and dark adapted electroretinogram", "Abnormal lip morphology", "Abnormal liver morphology", "Abnormal liver parenchyma morphology", "Abnormal liver physiology", "Abnormal localization of kidney", "Abnormal location of ears", "Abnormal lower limb bone morphology", "Abnormal lower motor neuron morphology", "Abnormal lumbar spine morphology", "Abnormal lung development", "Abnormal lung lobation", "Abnormal lymphatic vessel morphology", "Abnormal lymphocyte morphology", "Abnormal macrophage morphology", "Abnormal macroscopic urine appearance", "Abnormal macular morphology", "Abnormal magnesium concentration", "Abnormal male reproductive system physiology", "Abnormal mandibular ramus morphology", "Abnormal mean corpuscular hemoglobin concentration", "Abnormal mean corpuscular volume", "Abnormal megakaryocyte morphology", "Abnormal meningeal morphology", "Abnormal metabolic brain imaging by mrs", "Abnormal metabolism", "Abnormal metacarpal morphology", "Abnormal metaphyseal trabeculation", "Abnormal metatarsal morphology", "Abnormal midbrain morphology", "Abnormal middle phalanx morphology of the hand", "Abnormal mitochondria in muscle tissue", "Abnormal mitochondrial morphology", "Abnormal mitochondrial number", "Abnormal mitochondrial shape", "Abnormal mitral valve physiology", "Abnormal monocyte morphology", "Abnormal morphology of myocardial trabeculae", "Abnormal morphology of the abdominal musculature", "Abnormal morphology of the choroidal vasculature", "Abnormal morphology of the conjunctival vasculature", "Abnormal morphology of the great vessels", "Abnormal morphology of the limbic system", "Abnormal morphology of the musculature of the neck", "Abnormal morphology of the olfactory bulb", "Abnormal morphology of the radius", "Abnormal motor evoked potentials", "Abnormal motor nerve conduction velocity", "Abnormal muscle fiber alpha dystroglycan", "Abnormal muscle fiber morphology", "Abnormal muscle fiber protein expression", "Abnormal muscle fiber type distribution", "Abnormal muscle glycogen content", "Abnormal myelination", "Abnormal myeloid cell morphology", "Abnormal myeloid leukocyte morphology", "Abnormal myocardium morphology", "Abnormal nasal base", "Abnormal nasal bridge morphology", "Abnormal nasal mucosa morphology", "Abnormal nasolacrimal system morphology", "Abnormal natural killer cell morphology", "Abnormal natural killer cell physiology", "Abnormal nephron morphology", "Abnormal nerve conduction velocity", "Abnormal nervous system electrophysiology", "Abnormal neural tube morphology", "Abnormal neuron morphology", "Abnormal neutrophil count", "Abnormal nipple morphology", "Abnormal number of erythroid precursors", "Abnormal number of granulocyte precursors", "Abnormal number of incisors", "Abnormal number of teeth", "Abnormal odontoid tissue morphology", "Abnormal optical coherence tomography", "Abnormal oral frenulum morphology", "Abnormal oral mucosa morphology", "Abnormal oral physiology", "Abnormal ossification involving the femoral head and neck", "Abnormal ovarian morphology", "Abnormal ovarian physiology", "Abnormal palate morphology", "Abnormal palmar dermatoglyphics", "Abnormal pancreas morphology", "Abnormal pancreas size", "Abnormal paranasal sinus morphology", "Abnormal parietal bone morphology", "Abnormal parotid gland morphology", "Abnormal patella morphology", "Abnormal pattern of respiration", "Abnormal pelvis bone morphology", "Abnormal pelvis bone ossification", "Abnormal penis morphology", "Abnormal pericardium morphology", "Abnormal perifollicular morphology", "Abnormal peripheral action potential amplitude", "Abnormal peripheral myelination", "Abnormal peripheral nervous system morphology", "Abnormal peripheral nervous system physiology", "Abnormal peristalsis", "Abnormal periventricular white matter morphology", "Abnormal phalangeal joint morphology of the hand", "Abnormal pharynx morphology", "Abnormal pigmentation of the oral mucosa", "Abnormal pineal morphology", "Abnormal placenta morphology", "Abnormal placental membrane morphology", "Abnormal placental size", "Abnormal platelet aggregation", "Abnormal platelet function", "Abnormal platelet granules", "Abnormal platelet morphology", "Abnormal platelet volume", "Abnormal pleura morphology", "Abnormal pons morphology", "Abnormal posterior segment imaging", "Abnormal pr interval", "Abnormal preputium morphology", "Abnormal prolactin level", "Abnormal proportion of cd4 positive t cells", "Abnormal proportion of cd8 positive t cells", "Abnormal proportion of class switched memory b cells", "Abnormal proportion of double negative alpha beta regulatory t cell", "Abnormal prostate morphology", "Abnormal protein glycosylation", "Abnormal protein o linked glycosylation", "Abnormal proximal phalanx morphology of the hand", "Abnormal pulmonary interstitial morphology", "Abnormal pulmonary thoracic imaging finding", "Abnormal pulmonary valve morphology", "Abnormal pulmonary valve physiology", "Abnormal pupil morphology", "Abnormal pupillary function", "Abnormal pupillary light reflex", "Abnormal pyramidal sign", "Abnormal qrs complex", "Abnormal qt interval", "Abnormal rectum morphology", "Abnormal reflex", "Abnormal renal collecting system morphology", "Abnormal renal cortex morphology", "Abnormal renal corticomedullary differentiation", "Abnormal renal echogenicity", "Abnormal renal insterstitial morphology", "Abnormal renal medulla morphology", "Abnormal renal morphology", "Abnormal renal pelvis morphology", "Abnormal renal physiology", "Abnormal renal resorption", "Abnormal renal tubule morphology", "Abnormal renal vascular morphology", "Abnormal respiratory motile cilium morphology", "Abnormal respiratory motile cilium physiology", "Abnormal respiratory system morphology", "Abnormal response to acth stimulation test", "Abnormal response to endocrine stimulation test", "Abnormal response to insulin tolerance test", "Abnormal reticulocyte morphology", "Abnormal retinal artery morphology", "Abnormal retinal morphology", "Abnormal retinal vascular morphology", "Abnormal rib cage morphology", "Abnormal rib ossification", "Abnormal right atrium morphology", "Abnormal right ventricle morphology", "Abnormal right ventricular function", "Abnormal saccadic eye movements", "Abnormal sacroiliac joint morphology", "Abnormal sacrum morphology", "Abnormal salivary gland morphology", "Abnormal sarcomere morphology", "Abnormal scalp morphology", "Abnormal scapula morphology", "Abnormal sclera morphology", "Abnormal scrotal rugation", "Abnormal sella turcica morphology", "Abnormal sensory nerve conduction velocity", "Abnormal serum insulin like growth factor 1 level", "Abnormal serum interferon level", "Abnormal serum interleukin level", "Abnormal serum iron concentration", "Abnormal sex determination", "Abnormal shape of the frontal region", "Abnormal shape of the occiput", "Abnormal shape of the palpebral fissure", "Abnormal sharpey fiber morphology", "Abnormal shoulder morphology", "Abnormal shoulder physiology", "Abnormal size of pituitary gland", "Abnormal size of the clitoris", "Abnormal size of the palpebral fissures", "Abnormal skin morphology of the palm", "Abnormal social behavior", "Abnormal soft palate morphology", "Abnormal speech prosody", "Abnormal sperm motility", "Abnormal spermatogenesis", "Abnormal spinal meningeal morphology", "Abnormal sputum", "Abnormal st segment", "Abnormal sternal ossification", "Abnormal sternum morphology", "Abnormal stomach morphology", "Abnormal stool composition", "Abnormal subarachnoid space morphology", "Abnormal subclavian artery morphology", "Abnormal subcutaneous fat tissue distribution", "Abnormal substantia nigra morphology", "Abnormal superior cerebellar peduncle morphology", "Abnormal sweat gland morphology", "Abnormal sweat homeostasis", "Abnormal synaptic transmission at the neuromuscular junction", "Abnormal systemic arterial morphology", "Abnormal systemic blood pressure", "Abnormal t cell activation", "Abnormal t cell morphology", "Abnormal t cell proliferation", "Abnormal t cell subset distribution", "Abnormal t wave", "Abnormal talus morphology", "Abnormal temper tantrums", "Abnormal temporal bone morphology", "Abnormal tendon morphology", "Abnormal testis morphology", "Abnormal thalamic mri signal intensity", "Abnormal thalamic size", "Abnormal thoracic spine morphology", "Abnormal thorax morphology", "Abnormal thrombocyte morphology", "Abnormal thrombosis", "Abnormal thumb morphology", "Abnormal thyroid hormone level", "Abnormal thyroid morphology", "Abnormal thyroid stimulating hormone level", "Abnormal tissue metabolite concentration", "Abnormal toenail morphology", "Abnormal tongue morphology", "Abnormal tongue physiology", "Abnormal trabecular bone morphology", "Abnormal tracheal morphology", "Abnormal tracheobronchial morphology", "Abnormal transferrin saturation", "Abnormal tricuspid valve morphology", "Abnormal tricuspid valve physiology", "Abnormal umbilicus morphology", "Abnormal upper limb bone morphology", "Abnormal upper motor neuron morphology", "Abnormal ureter morphology", "Abnormal ureter physiology", "Abnormal urinary color", "Abnormal urinary electrolyte concentration", "Abnormal urine alpha ketoglutarate concentration", "Abnormal urine carbohydrate level", "Abnormal urine carboxylic acid level", "Abnormal urine cytology", "Abnormal urine hormone level", "Abnormal urine magnesium concentration", "Abnormal urine metabolite level", "Abnormal urine ph", "Abnormal urine phosphate concentration", "Abnormal urine potassium concentration", "Abnormal urine protein level", "Abnormal urine sodium concentration", "Abnormal uterus morphology", "Abnormal uvea morphology", "Abnormal uvula morphology", "Abnormal vagina morphology", "Abnormal vascular morphology", "Abnormal vascular physiology", "Abnormal vena cava morphology", "Abnormal venous morphology", "Abnormal ventricular septum morphology", "Abnormal vertebral morphology", "Abnormal vertebral segmentation and fusion", "Abnormal vestibulo ocular reflex", "Abnormal visual electrophysiology", "Abnormal visual field test", "Abnormal visual fixation", "Abnormal vitamin b12 level", "Abnormal vitreous humor morphology", "Abnormal waist to hip ratio", "Abnormal z disc morphology", "Abnormalities of placenta or umbilical cord", "Abnormality iris morphology", "Abnormality of abdominal situs", "Abnormality of acid base homeostasis", "Abnormality of adrenal morphology", "Abnormality of adrenal physiology", "Abnormality of alkaline phosphatase level", "Abnormality of amino acid metabolism", "Abnormality of bladder morphology", "Abnormality of blood circulation", "Abnormality of blood volume homeostasis", "Abnormality of body mass index", "Abnormality of bone marrow cell morphology", "Abnormality of bone mineral density", "Abnormality of canine", "Abnormality of cardiovascular system electrophysiology", "Abnormality of carpal bone ossification", "Abnormality of cartilage of external ear", "Abnormality of central nervous system electrophysiology", "Abnormality of chorioretinal pigmentation", "Abnormality of chromosome segregation", "Abnormality of chromosome stability", "Abnormality of circulating adrenocorticotropin level", "Abnormality of circulating enzyme level", "Abnormality of circulating fibrinogen", "Abnormality of circulating glucocorticoid level", "Abnormality of circulating leptin level", "Abnormality of coagulation", "Abnormality of complement system", "Abnormality of coordination", "Abnormality of corneal size", "Abnormality of corneal stroma", "Abnormality of corneal thickness", "Abnormality of cranial sutures", "Abnormality of dental color", "Abnormality of dental eruption", "Abnormality of dental morphology", "Abnormality of dental structure", "Abnormality of dermal melanosomes", "Abnormality of digestive system morphology", "Abnormality of dna repair", "Abnormality of earlobe", "Abnormality of endocrine pancreas physiology", "Abnormality of epiphysis morphology", "Abnormality of exocrine pancreas physiology", "Abnormality of extrapyramidal motor function", "Abnormality of facial adipose tissue", "Abnormality of facial musculature", "Abnormality of facial skeleton", "Abnormality of facial soft tissue", "Abnormality of female external genitalia", "Abnormality of femur morphology", "Abnormality of fibula morphology", "Abnormality of finger", "Abnormality of fluid regulation", "Abnormality of folate metabolism", "Abnormality of fontanelles", "Abnormality of foveal pigmentation", "Abnormality of frontal sinus", "Abnormality of frontalis muscle belly", "Abnormality of fundus pigmentation", "Abnormality of globe location", "Abnormality of globe size", "Abnormality of glycolipid metabolism", "Abnormality of hair growth", "Abnormality of hair pigmentation", "Abnormality of hair texture", "Abnormality of hand joint mobility", "Abnormality of head blood vessel", "Abnormality of hepatobiliary system physiology", "Abnormality of hindbrain morphology", "Abnormality of humoral immunity", "Abnormality of immune serum protein physiology", "Abnormality of iron homeostasis", "Abnormality of krebs cycle metabolism", "Abnormality of lens shape", "Abnormality of limb epiphysis morphology", "Abnormality of lipoprotein cholesterol concentration", "Abnormality of long bone morphology", "Abnormality of lower limb epiphysis morphology", "Abnormality of lower limb joint", "Abnormality of lower limb metaphyses", "Abnormality of lower lip", "Abnormality of lysosomal metabolism", "Abnormality of macular pigmentation", "Abnormality of malar bones", "Abnormality of male internal genitalia", "Abnormality of metacarpal epiphyses", "Abnormality of metacarpophalangeal joint", "Abnormality of mouth shape", "Abnormality of mouth size", "Abnormality of muscle size", "Abnormality of nail color", "Abnormality of neuronal migration", "Abnormality of neutrophil morphology", "Abnormality of neutrophil physiology", "Abnormality of neutrophils", "Abnormality of ocular smooth pursuit", "Abnormality of pain sensation", "Abnormality of pancreas physiology", "Abnormality of pelvic girdle bone morphology", "Abnormality of periauricular region", "Abnormality of peripheral nerves", "Abnormality of prenatal development or birth", "Abnormality of primary teeth", "Abnormality of prothrombin", "Abnormality of pulmonary circulation", "Abnormality of refraction", "Abnormality of renal excretion", "Abnormality of renin angiotensin system", "Abnormality of reproductive system physiology", "Abnormality of retinal pigmentation", "Abnormality of salivation", "Abnormality of secondary sexual hair", "Abnormality of skeletal maturation", "Abnormality of skeletal muscle fiber size", "Abnormality of skin adnexa physiology", "Abnormality of skin physiology", "Abnormality of skin pigmentation", "Abnormality of skull ossification", "Abnormality of small intestinal villus morphology", "Abnormality of somatosensory evoked potentials", "Abnormality of subcutaneous fat tissue", "Abnormality of t cell physiology", "Abnormality of taste sensation", "Abnormality of temperature regulation", "Abnormality of thalamus morphology", "Abnormality of the 1st metacarpal", "Abnormality of the 2nd toe", "Abnormality of the 3rd toe", "Abnormality of the 4th metacarpal", "Abnormality of the 5th metacarpal", "Abnormality of the 5th toe", "Abnormality of the abdominal organs", "Abnormality of the abdominal wall", "Abnormality of the achilles tendon", "Abnormality of the adrenal glands", "Abnormality of the alveolar ridges", "Abnormality of the amniotic fluid", "Abnormality of the ankles", "Abnormality of the anterior fontanelle", "Abnormality of the antihelix", "Abnormality of the antitragus", "Abnormality of the anus", "Abnormality of the auditory canal", "Abnormality of the autonomic nervous system", "Abnormality of the axillary hair", "Abnormality of the basal ganglia", "Abnormality of the biliary system", "Abnormality of the bladder", "Abnormality of the brainstem white matter", "Abnormality of the breast", "Abnormality of the calcaneus", "Abnormality of the calf", "Abnormality of the calf musculature", "Abnormality of the calvaria", "Abnormality of the carpal bones", "Abnormality of the cerebral subcortex", "Abnormality of the cerebrospinal fluid", "Abnormality of the cervical spine", "Abnormality of the cheek", "Abnormality of the chin", "Abnormality of the choanae", "Abnormality of the clitoris", "Abnormality of the coagulation cascade", "Abnormality of the columella", "Abnormality of the common coagulation pathway", "Abnormality of the costochondral junction", "Abnormality of the crus of the helix", "Abnormality of the curvature of the cornea", "Abnormality of the curvature of the vertebral column", "Abnormality of the dentition", "Abnormality of the diaphragm", "Abnormality of the diencephalon", "Abnormality of the distal phalanges of the toes", "Abnormality of the distal phalanx of the thumb", "Abnormality of the dorsal column of the spinal cord", "Abnormality of the elbow", "Abnormality of the endometrium", "Abnormality of the epididymis", "Abnormality of the epiphyses of the distal phalanx of finger", "Abnormality of the eustachian tube", "Abnormality of the external nose", "Abnormality of the extraocular muscles", "Abnormality of the extrinsic pathway", "Abnormality of the female genitalia", "Abnormality of the fetal cardiovascular system", "Abnormality of the fifth metatarsal bone", "Abnormality of the fontanelles or cranial sutures", "Abnormality of the foot musculature", "Abnormality of the forearm", "Abnormality of the forehead", "Abnormality of the frontal hairline", "Abnormality of the gallbladder", "Abnormality of the gastric mucosa", "Abnormality of the gingiva", "Abnormality of the glabella", "Abnormality of the glenoid fossa", "Abnormality of the hairline", "Abnormality of the hallux", "Abnormality of the helix", "Abnormality of the hepatic vasculature", "Abnormality of the humeroradial joint", "Abnormality of the humerus", "Abnormality of the hypothalamus pituitary axis", "Abnormality of the hypothenar eminence", "Abnormality of the incisor", "Abnormality of the inner ear", "Abnormality of the internal auditory canal", "Abnormality of the intervertebral disk", "Abnormality of the intrahepatic bile duct", "Abnormality of the intrinsic pathway", "Abnormality of the ischium", "Abnormality of the kidney", "Abnormality of the knee", "Abnormality of the larynx", "Abnormality of the lens", "Abnormality of the leydig cells", "Abnormality of the liver", "Abnormality of the lower urinary tract", "Abnormality of the lymph nodes", "Abnormality of the lymphatic system", "Abnormality of the mastoid", "Abnormality of the maxilla", "Abnormality of the menstrual cycle", "Abnormality of the metacarpal bones", "Abnormality of the metaphysis", "Abnormality of the metopic suture", "Abnormality of the middle ear", "Abnormality of the middle ear ossicles", "Abnormality of the middle phalanx of the 5th finger", "Abnormality of the midface", "Abnormality of the mitochondrion", "Abnormality of the musculature of the hand", "Abnormality of the musculature of the limbs", "Abnormality of the musculature of the lower limbs", "Abnormality of the musculature of the thigh", "Abnormality of the musculature of the upper arm", "Abnormality of the musculature of the upper limbs", "Abnormality of the nail", "Abnormality of the nasal alae", "Abnormality of the nasal bone", "Abnormality of the nasal cavity", "Abnormality of the nasal dorsum", "Abnormality of the nasal septum", "Abnormality of the nasal skeleton", "Abnormality of the nasal tip", "Abnormality of the nasolabial region", "Abnormality of the neck", "Abnormality of the odontoid process", "Abnormality of the optic nerve", "Abnormality of the outer ear", "Abnormality of the ovary", "Abnormality of the palm", "Abnormality of the palpebral fissures", "Abnormality of the pancreas", "Abnormality of the parathyroid gland", "Abnormality of the parathyroid morphology", "Abnormality of the periorbital region", "Abnormality of the peripheral nervous system", "Abnormality of the peritoneum", "Abnormality of the periungual region", "Abnormality of the phalanges of the 2nd finger", "Abnormality of the phalanges of the hallux", "Abnormality of the phalanges of the toes", "Abnormality of the pharynx", "Abnormality of the philtrum", "Abnormality of the pineal gland", "Abnormality of the pinna", "Abnormality of the pituitary gland", "Abnormality of the plantar skin of foot", "Abnormality of the posterior pituitary", "Abnormality of the protein c anticoagulant pathway", "Abnormality of the proximal phalanx of the thumb", "Abnormality of the pubic bone", "Abnormality of the pubic hair", "Abnormality of the pulmonary artery", "Abnormality of the pulmonary vasculature", "Abnormality of the pulmonary veins", "Abnormality of the pylorus", "Abnormality of the radial head", "Abnormality of the radioulnar joints", "Abnormality of the ribs", "Abnormality of the scrotum", "Abnormality of the sense of smell", "Abnormality of the septum pellucidum", "Abnormality of the shoulder girdle musculature", "Abnormality of the skull base", "Abnormality of the small intestine", "Abnormality of the spinal cord", "Abnormality of the spinocerebellar tracts", "Abnormality of the spleen", "Abnormality of the stapes", "Abnormality of the subungual region", "Abnormality of the supraorbital ridges", "Abnormality of the synovia", "Abnormality of the tarsal bones", "Abnormality of the temporomandibular joint", "Abnormality of the testis size", "Abnormality of the thenar eminence", "Abnormality of the thoracic cavity", "Abnormality of the thymus", "Abnormality of the thyroid gland", "Abnormality of the tongue", "Abnormality of the tongue muscle", "Abnormality of the tonsils", "Abnormality of the tragus", "Abnormality of the ulna", "Abnormality of the umbilical cord", "Abnormality of the upper arm", "Abnormality of the upper respiratory tract", "Abnormality of the ureter", "Abnormality of the urethra", "Abnormality of the urinary system physiology", "Abnormality of the uterus", "Abnormality of the vasculature of the eye", "Abnormality of the vertebral endplates", "Abnormality of the vestibulocochlear nerve", "Abnormality of the voice", "Abnormality of the wrist", "Abnormality of the zygomatic bone", "Abnormality of thyroid physiology", "Abnormality of tibia morphology", "Abnormality of toe", "Abnormality of ulnar metaphysis", "Abnormality of upper limb epiphysis morphology", "Abnormality of upper limb joint", "Abnormality of upper limb metaphysis", "Abnormality of upper lip", "Abnormality of upper lip vermillion", "Abnormality of urinary uric acid concentration", "Abnormality of urine calcium concentration", "Abnormality of urine catecholamine concentration", "Abnormality of urine homeostasis", "Abnormality of visual evoked potentials", "Abnormality of vitamin a metabolism", "Abnormality of vitamin b metabolism", "Abnormality of vitamin b12 metabolism", "Abnormality of vitamin d metabolism", "Abnormality of vitamin e metabolism", "Abnormality of vitamin k metabolism", "Abnormality of vitamin metabolism", "Abnormality on pulmonary function testing", "Abnormally folded helix", "Abnormally large globe", "Abnormally lax or hyperextensible skin", "Abnormally low pitched voice", "Abnormally ossified vertebrae", "Abnormally shaped carpal bones", "Abscess", "Absence of pubertal development", "Absence of secondary sex characteristics", "Absence of subcutaneous fat", "Absence of the sacrum", "Absent axillary hair", "Absent brainstem auditory responses", "Absent distal phalanges", "Absent earlobe", "Absent epiphyses", "Absent eyebrow", "Absent facial hair", "Absent fingernail", "Absent forearm bone", "Absent foveal reflex", "Absent frontal sinuses", "Absent hair", "Absent hand", "Absent hypoplastic paranasal sinuses", "Absent nipple", "Absent or minimally ossified vertebral bodies", "Absent outer dynein arms", "Absent palmar crease", "Absent septum pellucidum", "Absent shortened dynein arms", "Absent speech", "Absent sternal ossification", "Absent testis", "Absent thumb", "Absent thumbnail", "Absent toe", "Absent toenail", "Acanthocytosis", "Acantholysis", "Acanthosis nigricans", "Accelerated atherosclerosis", "Accelerated skeletal maturation", "Accessory oral frenulum", "Accessory spleen", "Acetabular dysplasia", "Achilles tendon contracture", "Acidemia", "Acne", "Acne inversa", "Acquired abnormal hair pattern", "Acral blistering", "Acral ulceration", "Acromesomelia", "Acroparesthesia", "Action tremor", "Acute coronary syndrome", "Acute encephalopathy", "Acute hepatic failure", "Acute kidney injury", "Acute leukemia", "Acute lymphoblastic leukemia", "Acute myeloid leukemia", "Acute pancreatitis", "Acute phase response", "Addictive behavior", "Adducted thumb", "Adenocarcinoma of the colon", "Adenocarcinoma of the intestines", "Adenocarcinoma of the small intestine", "Adenoma sebaceum", "Adenomatous colonic polyposis", "Adipose tissue loss", "Adrenal hyperplasia", "Adrenal hypoplasia", "Adrenal insufficiency", "Adrenal overactivity", "Adrenocortical abnormality", "Adrenocortical carcinoma", "Adrenocorticotropic hormone deficiency", "Adrenocorticotropic hormone excess", "Adrenocorticotropin deficient adrenal insufficiency", "Adult onset", "Advanced eruption of teeth", "Advanced ossification of carpal bones", "Agammaglobulinemia", "Aganglionic megacolon", "Agenesis of central incisor", "Agenesis of cerebellar vermis", "Agenesis of corpus callosum", "Agenesis of incisor", "Aggressive behavior", "Agitation", "Agnosia", "Agyria", "Airway obstruction", "Akinesia", "Alacrima", "Albinism", "Albuminuria", "Alexia", "Alkalosis", "Allergic rhinitis", "Allergy", "Alopecia", "Alopecia of scalp", "Alopecia totalis", "Alopecia universalis", "Alternating esotropia", "Alveolar cell carcinoma", "Alveolar ridge overgrowth", "Alzheimer disease", "Amaurosis fugax", "Ambiguous genitalia", "Ambiguous genitalia female", "Ambiguous genitalia male", "Amblyopia", "Amegakaryocytic thrombocytopenia", "Amelogenesis imperfecta", "Amenorrhea", "Aminoaciduria", "Amniotic constriction ring", "Amyloidosis", "Amyotrophic lateral sclerosis", "Anal atresia", "Anal stenosis", "Anarthria", "Anasarca", "Anemia of inadequate production", "Anemic pallor", "Anencephaly", "Angina pectoris", "Angioedema", "Angiofibromas", "Angioid streaks of the fundus", "Angiokeratoma", "Angular cheilitis", "Anhidrosis", "Aniridia", "Anisocoria", "Anisocytosis", "Anisopoikilocytosis", "Anisospondyly", "Ankle clonus", "Ankle flexion contracture", "Ankle weakness", "Ankyloblepharon", "Ankyloglossia", "Ankylosis", "Annular pancreas", "Anodontia", "Anomalous trichromacy", "Anomic aphasia", "Anonychia", "Anophthalmia", "Anorectal anomaly", "Anorexia", "Anosmia", "Anotia", "Antenatal onset", "Anterior open bite malocclusion", "Anterior pituitary dysgenesis", "Anterior plagiocephaly", "Anterior rib cupping", "Anterior uveitis", "Anteriorly placed anus", "Anteverted ears", "Anti thyroid peroxidase antibody positivity", "Antineutrophil antibody positivity", "Antinuclear antibody positivity", "Antiphospholipid antibody positivity", "Aortic aneurysm", "Aortic arch aneurysm", "Aortic atherosclerotic lesion", "Aortic dissection", "Aortic regurgitation", "Aortic root aneurysm", "Aortic valve calcification", "Aortic valve stenosis", "Aphasia", "Aphthous ulcer", "Aplasia cutis congenita", "Aplasia cutis congenita of scalp", "Aplasia cutis congenita on trunk or limbs", "Aplasia cutis congenita over the scalp vertex", "Aplasia hypoplasia affecting bones of the axial skeleton", "Aplasia hypoplasia affecting the anterior segment of the eye", "Aplasia hypoplasia affecting the eye", "Aplasia hypoplasia affecting the fundus", "Aplasia hypoplasia involving bones of the feet", "Aplasia hypoplasia involving bones of the lower limbs", "Aplasia hypoplasia involving bones of the thorax", "Aplasia hypoplasia involving bones of the upper limbs", "Aplasia hypoplasia involving forearm bones", "Aplasia hypoplasia involving the carpal bones", "Aplasia hypoplasia involving the femoral head and neck", "Aplasia hypoplasia involving the metacarpal bones", "Aplasia hypoplasia involving the musculature of the upper limbs", "Aplasia hypoplasia involving the nose", "Aplasia hypoplasia involving the pelvis", "Aplasia hypoplasia involving the sinuses", "Aplasia hypoplasia involving the skeletal musculature", "Aplasia hypoplasia involving the skeleton", "Aplasia hypoplasia involving the vertebral column", "Aplasia hypoplasia of fingers", "Aplasia hypoplasia of metatarsal bones", "Aplasia hypoplasia of the 2nd finger", "Aplasia hypoplasia of the 4th metacarpal", "Aplasia hypoplasia of the 5th finger", "Aplasia hypoplasia of the 5th metacarpal", "Aplasia hypoplasia of the abdominal wall musculature", "Aplasia hypoplasia of the bladder", "Aplasia hypoplasia of the breasts", "Aplasia hypoplasia of the capital femoral epiphysis", "Aplasia hypoplasia of the cerebellar vermis", "Aplasia hypoplasia of the cerebellum", "Aplasia hypoplasia of the cerebral white matter", "Aplasia hypoplasia of the clavicles", "Aplasia hypoplasia of the colon", "Aplasia hypoplasia of the distal phalanges of the hand", "Aplasia hypoplasia of the distal phalanx of the thumb", "Aplasia hypoplasia of the ear", "Aplasia hypoplasia of the earlobes", "Aplasia hypoplasia of the epiglottis", "Aplasia hypoplasia of the extremities", "Aplasia hypoplasia of the eyebrow", "Aplasia hypoplasia of the eyelid", "Aplasia hypoplasia of the femur", "Aplasia hypoplasia of the fibula", "Aplasia hypoplasia of the gallbladder", "Aplasia hypoplasia of the hallux", "Aplasia hypoplasia of the humerus", "Aplasia hypoplasia of the lungs", "Aplasia hypoplasia of the nails", "Aplasia hypoplasia of the nasal bone", "Aplasia hypoplasia of the nasal septum", "Aplasia hypoplasia of the nipples", "Aplasia hypoplasia of the optic nerve", "Aplasia hypoplasia of the ovary", "Aplasia hypoplasia of the palmar creases", "Aplasia hypoplasia of the patella", "Aplasia hypoplasia of the phalanges of the 2nd finger", "Aplasia hypoplasia of the phalanges of the hand", "Aplasia hypoplasia of the phalanges of the thumb", "Aplasia hypoplasia of the phalanges of the toes", "Aplasia hypoplasia of the proximal phalanges of the hand", "Aplasia hypoplasia of the pubic bone", "Aplasia hypoplasia of the radius", "Aplasia hypoplasia of the retina", "Aplasia hypoplasia of the ribs", "Aplasia hypoplasia of the sacrum", "Aplasia hypoplasia of the scapulae", "Aplasia hypoplasia of the skin", "Aplasia hypoplasia of the spleen", "Aplasia hypoplasia of the sternum", "Aplasia hypoplasia of the thumb", "Aplasia hypoplasia of the thymus", "Aplasia hypoplasia of the thyroid gland", "Aplasia hypoplasia of the tibia", "Aplasia hypoplasia of the tongue", "Aplasia hypoplasia of the tragus", "Aplasia hypoplasia of the ulna", "Aplasia hypoplasia of the uterus", "Aplasia hypoplasia of the uvula", "Aplasia hypoplasia of the vagina", "Aplasia hypoplasia of toe", "Aplasia involving bones of the extremities", "Aplasia involving bones of the lower limbs", "Aplasia of metacarpal bones", "Aplasia of the fingers", "Aplasia of the middle phalanx of the hand", "Aplasia of the phalanges of the hand", "Aplasia of the phalanges of the toes", "Aplasia of the proximal phalanges of the hand", "Aplasia of the semicircular canal", "Aplasia of the uterus", "Aplastic anemia", "Aplastic clavicle", "Aplastic hypoplastic lacrimal glands", "Aplastic hypoplastic toenail", "Apnea", "Apneic episodes precipitated by illness fatigue stress", "Appendicular hypotonia", "Apraxia", "Aqueductal stenosis", "Arachnodactyly", "Arachnoid hemangiomatosis", "Areflexia", "Areflexia of lower limbs", "Arm dystonia", "Arnold chiari malformation", "Arnold chiari type i malformation", "Arrhinencephaly", "Arteria lusoria", "Arterial dissection", "Arterial rupture", "Arterial stenosis", "Arterial thrombosis", "Arteriosclerosis", "Arteriovenous malformation", "Arthralgia", "Arthritis", "Arthrogryposis multiplex congenita", "Arthropathy", "Ascending aortic dissection", "Ascending tubular aorta aneurysm", "Ascites", "Aspiration", "Aspiration pneumonia", "Asterixis", "Asthenia", "Asthma", "Astigmatism", "Astrocytoma", "Astrocytosis", "Asymmetric growth", "Asymmetric septal hypertrophy", "Asymmetry of spinal facet joints", "Asymmetry of the ears", "Atelectasis", "Athetosis", "Atlantoaxial abnormality", "Atlantoaxial dislocation", "Atlantoaxial instability", "Atonic seizure", "Atopic dermatitis", "Atresia of the external auditory canal", "Atrial arrhythmia", "Atrial flutter", "Atrioventricular canal defect", "Atrophic scars", "Atrophy degeneration affecting the brainstem", "Atrophy degeneration affecting the central nervous system", "Atrophy degeneration affecting the cerebrum", "Atrophy degeneration involving the caudate nucleus", "Atrophy degeneration involving the corticospinal tracts", "Atrophy degeneration involving the spinal cord", "Atrophy of alveolar ridges", "Attention deficit hyperactivity disorder", "Attenuation of retinal blood vessels", "Atypical absence seizure", "Auditory hallucinations", "Autism", "Autistic behavior", "Autoamputation", "Autoamputation of digits", "Autoimmune antibody positivity", "Autoimmune hemolytic anemia", "Autoimmune thrombocytopenia", "Autoimmunity", "Autophagic vacuoles", "Autosomal dominant germline de novo mutation", "Avascular necrosis", "Avascular necrosis of the capital femoral epiphysis", "Axial dystonia", "Axial muscle weakness", "Axillary pterygium", "Axonal degeneration", "Axonal degeneration regeneration", "Axonal loss", "Axonal regeneration", "Azoospermia", "B cell lymphoma", "B lymphocytopenia", "Babinski sign", "Back pain", "Bacterial endocarditis", "Barrel shaped chest", "Barrett esophagus", "Basal cell carcinoma", "Basal ganglia calcification", "Basal ganglia cysts", "Basal ganglia gliosis", "Basilar invagination", "Beaded ribs", "Beaking of vertebral bodies", "Bell shaped thorax", "Benign neoplasm of the central nervous system", "Bicarbonaturia", "Biconcave vertebral bodies", "Bicornuate uterus", "Bifid epiglottis", "Bifid nasal tip", "Bifid ribs", "Bifid scrotum", "Bifid tongue", "Bifid uterus", "Bifid uvula", "Bilateral camptodactyly", "Bilateral cleft lip", "Bilateral cleft lip and palate", "Bilateral cleft palate", "Bilateral coxa valga", "Bilateral cryptorchidism", "Bilateral external ear deformity", "Bilateral microphthalmos", "Bilateral polymicrogyria", "Bilateral ptosis", "Bilateral sensorineural hearing impairment", "Bilateral single transverse palmar creases", "Bilateral talipes equinovarus", "Bilateral tonic clonic seizure", "Bilateral tonic clonic seizure with focal onset", "Bilateral tonic clonic seizure with generalized onset", "Bile duct proliferation", "Biliary atresia", "Biliary cirrhosis", "Biliary tract abnormality", "Biliary tract neoplasm", "Bimanual synkinesia", "Biparietal narrowing", "Bird like facies", "Birth length greater than 97th percentile", "Birth length less than 3rd percentile", "Biventricular hypertrophy", "Bladder diverticulum", "Bladder neoplasm", "Blepharitis", "Blepharophimosis", "Blindness", "Blistering by anatomical location", "Blistering by histological location", "Bloodstream infectious agent", "Bloody diarrhea", "Blue irides", "Blue nevus", "Blue sclerae", "Blurred vision", "Bone cyst", "Bone fracture", "Bone marrow foam cells", "Bone marrow hypercellularity", "Bone marrow hypocellularity", "Bone pain", "Bone spicule pigmentation of the retina", "Bowel diverticulosis", "Bowing of the arm", "Bowing of the legs", "Brachycephaly", "Brachydactyly", "Brachyturricephaly", "Bradycardia", "Bradykinesia", "Brain imaging abnormality", "Brain neoplasm", "Brain stem compression", "Branchial anomaly", "Branchial cyst", "Branchial fistula", "Breast aplasia", "Breast carcinoma", "Breast hypoplasia", "Breathing dysregulation", "Breech presentation", "Brisk reflexes", "Brittle hair", "Broad alveolar ridges", "Broad based gait", "Broad chin", "Broad clavicles", "Broad columella", "Broad distal phalanx of finger", "Broad eyebrow", "Broad face", "Broad femoral neck", "Broad finger", "Broad foot", "Broad forehead", "Broad hallux phalanx", "Broad jaw", "Broad long bones", "Broad metacarpals", "Broad nail", "Broad nasal tip", "Broad neck", "Broad palm", "Broad phalanx of the toes", "Broad philtrum", "Broad ribs", "Broad thumb", "Broad toe", "Bronchiectasis", "Bronchitis", "Bronchomalacia", "Bronchospasm", "Bruising susceptibility", "Brushfield spots", "Bruxism", "Bulbar palsy", "Bulbar signs", "Bulbous nose", "Bull s eye maculopathy", "Bundle branch block", "Buphthalmos", "Burkitt lymphoma", "Butterfly vertebrae", "Cachexia", "Caesarian section", "Cafe au lait spot", "Calcific stippling", "Calcification of cartilage", "Calcification of the aorta", "Calcinosis", "Calcium nephrolithiasis", "Calcium oxalate nephrolithiasis", "Calf muscle pseudohypertrophy", "Calvarial hyperostosis", "Calvarial osteosclerosis", "Calvarial skull defect", "Camptodactyly of toe", "Capillary hemangioma", "Capillary malformation", "Capitate hamate fusion", "Carcinoid tumor", "Carcinoma", "Cardiac arrest", "Cardiac conduction abnormality", "Cardiac diverticulum", "Cardiac shunt", "Cardiac valve calcification", "Cardiomegaly", "Cardiorespiratory arrest", "Cardiovascular calcification", "Carious teeth", "Carpal bone hypoplasia", "Carpal synostosis", "Cataplexy", "Caudate atrophy", "Cavernous hemangioma", "Cavum septum pellucidum", "Celiac disease", "Cellular immunodeficiency", "Cellulitis", "Central adrenal insufficiency", "Central apnea", "Central diabetes insipidus", "Central heterochromia", "Central hypothyroidism", "Central hypoventilation", "Central nervous system cyst", "Central primitive neuroectodermal tumor", "Central scotoma", "Central sleep apnea", "Central y shaped metacarpal", "Centrally nucleated skeletal muscle fibers", "Centrocecal scotoma", "Cerebellar atrophy", "Cerebellar cortical atrophy", "Cerebellar cyst", "Cerebellar dysplasia", "Cerebellar hemorrhage", "Cerebellar hypoplasia", "Cerebellar malformation", "Cerebellar vermis atrophy", "Cerebral amyloid angiopathy", "Cerebral calcification", "Cerebral cortical atrophy", "Cerebral dysmyelination", "Cerebral edema", "Cerebral hamartoma", "Cerebral hemorrhage", "Cerebral hypomyelination", "Cerebral hypoplasia", "Cerebral inclusion bodies", "Cerebral palsy", "Cerebral venous thrombosis", "Cerebral visual impairment", "Cerebral white matter atrophy", "Cerebral white matter hypoplasia", "Cervical kyphosis", "Cervical myelopathy", "Cervical ribs", "Cervical spinal canal stenosis", "Cervical spine instability", "Cervical subluxation", "Cessation of head growth", "Cheilitis", "Cherry red spot of the macula", "Chest pain", "Chilblains", "Childhood onset", "Childhood onset sensorineural hearing impairment", "Childhood onset truncal obesity", "Chills", "Choanal stenosis", "Choking episodes", "Cholangiocarcinoma", "Cholangitis", "Cholecystitis", "Cholestasis", "Cholestatic liver disease", "Chondrocalcinosis", "Chondrosarcoma", "Chordee", "Chorea", "Choreoathetosis", "Choriocarcinoma", "Chorioretinal atrophy", "Chorioretinal coloboma", "Chorioretinal degeneration", "Chorioretinal dysplasia", "Chorioretinal dystrophy", "Chorioretinal hypopigmentation", "Choroid plexus carcinoma", "Choroid plexus cyst", "Choroidal melanoma", "Choroidal neovascularization", "Chromosomal breakage induced by crosslinking agents", "Chromosomal breakage induced by ionizing radiation", "Chromosome breakage", "Chronic atrophic gastritis", "Chronic axonal neuropathy", "Chronic bronchitis", "Chronic constipation", "Chronic diarrhea", "Chronic fatigue", "Chronic hemolytic anemia", "Chronic hepatic failure", "Chronic infection", "Chronic kidney disease", "Chronic leukemia", "Chronic lung disease", "Chronic lymphatic leukemia", "Chronic mucocutaneous candidiasis", "Chronic neutropenia", "Chronic noninfectious lymphadenopathy", "Chronic oral candidiasis", "Chronic otitis media", "Chronic pulmonary obstruction", "Chronic rhinitis", "Chronic sinusitis", "Chylothorax", "Cigarette paper scars", "Cirrhosis", "Cleft hard palate", "Cleft lip", "Cleft soft palate", "Cleft upper lip", "Clinodactyly", "Clitoral hypoplasia", "Clonic seizure", "Clonus", "Cloverleaf skull", "Clubbing", "Clubbing of fingers", "Clubbing of toes", "Clumsiness", "Cns demyelination", "Cns hypomyelination", "Coarctation of aorta", "Coarse facial features", "Coarse hair", "Cochlear malformation", "Cognitive impairment", "Cogwheel rigidity", "Cold induced muscle cramps", "Colitis", "Collectionism", "Coloboma", "Colon cancer", "Color vision defect", "Color vision test abnormality", "Colorectal polyposis", "Colpocephaly", "Coma", "Combined immunodeficiency", "Communicating hydrocephalus", "Compensatory head posture", "Complete atrioventricular canal defect", "Complete duplication of phalanx of hand", "Complex febrile seizure", "Concave nail", "Concave nasal ridge", "Concentric hypertrophic cardiomyopathy", "Cone cone rod dystrophy", "Cone shaped epiphyses of the phalanges of the hand", "Cone shaped epiphysis", "Confetti like hypopigmented macules", "Confusion", "Congenital adrenal hyperplasia", "Congenital bilateral hip dislocation", "Congenital blindness", "Congenital contracture", "Congenital craniofacial dysostosis", "Congenital diaphragmatic hernia", "Congenital hemolytic anemia", "Congenital hepatic fibrosis", "Congenital hip dislocation", "Congenital hypothyroidism", "Congenital ichthyosiform erythroderma", "Congenital localized absence of skin", "Congenital malformation of the great arteries", "Congenital malformation of the left heart", "Congenital malformation of the right heart", "Congenital muscular dystrophy", "Congenital muscular torticollis", "Congenital nonbullous ichthyosiform erythroderma", "Congenital nystagmus", "Congenital onset", "Congenital posterior urethral valve", "Congenital sensorineural hearing impairment", "Congenital stationary night blindness", "Congenital thrombocytopenia", "Congestive heart failure", "Conical incisor", "Conical tooth", "Conjugated hyperbilirubinemia", "Conjunctival hamartoma", "Connective tissue nevi", "Conspicuously happy disposition", "Constipation", "Constitutional symptom", "Constriction of peripheral visual field", "Contiguous gene syndrome", "Contractures involving the joints of the feet", "Contractures of the joints of the lower limbs", "Contractures of the joints of the upper limbs", "Contractures of the large joints", "Convex nasal ridge", "Coombs positive hemolytic anemia", "Cor pulmonale", "Corneal dystrophy", "Corneal erosion", "Corneal neovascularization", "Corneal opacity", "Corneal scarring", "Corneal ulceration", "Coronal cleft vertebrae", "Coronal craniosynostosis", "Coronary artery atherosclerosis", "Corpus callosum atrophy", "Cortical cataract", "Cortical dysplasia", "Cortical myoclonus", "Cortical thickening of long bone diaphyses", "Corticospinal tract hypoplasia", "Cough", "Coxa valga", "Coxa vara", "Crackles", "Cranial asymmetry", "Cranial hyperostosis", "Cranial nerve compression", "Craniofacial asymmetry", "Craniofacial dysostosis", "Craniofacial hyperostosis", "Craniofacial osteosclerosis", "Craniosynostosis", "Crumpled long bones", "Cryptorchidism", "Csf lymphocytic pleiocytosis", "Csf pleocytosis", "Cubitus valgus", "Cupped ear", "Cupped ribs", "Curly eyelashes", "Curly hair", "Cutaneous abscess", "Cutaneous amyloidosis", "Cutaneous cyst", "Cutaneous finger syndactyly", "Cutaneous melanoma", "Cutaneous photosensitivity", "Cutaneous syndactyly", "Cutaneous syndactyly of toes", "Cutis laxa", "Cutis marmorata", "Cyanosis", "Cyanotic episode", "Cyclopia", "Cystic hygroma", "Cystic liver disease", "Cystic renal dysplasia", "Cystinuria", "Cystoid macular edema", "Cytochrome c oxidase negative muscle fibers", "Dark urine", "Death in adolescence", "Death in adulthood", "Death in childhood", "Death in infancy", "Decerebrate rigidity", "Decreased absent ankle reflexes", "Decreased activity of mitochondrial complex i", "Decreased activity of mitochondrial complex ii", "Decreased activity of mitochondrial complex iii", "Decreased activity of mitochondrial complex iv", "Decreased activity of nadph oxidase", "Decreased activity of the pyruvate dehydrogenase complex", "Decreased adenosylcobalamin", "Decreased adipose tissue", "Decreased calvarial ossification", "Decreased cd4 cd8 ratio", "Decreased cervical spine flexion due to contractures of posterior cervical muscles", "Decreased cervical spine mobility", "Decreased circulating acth level", "Decreased circulating aldosterone level", "Decreased circulating androgen concentration", "Decreased circulating antibody level", "Decreased circulating copper concentration", "Decreased circulating cortisol level", "Decreased circulating follicle stimulating hormone concentration", "Decreased circulating gaba concentration", "Decreased circulating gonadotropin concentration", "Decreased circulating iga level", "Decreased circulating igg level", "Decreased circulating igg subclass level", "Decreased circulating level of specific antibody", "Decreased circulating progesterone", "Decreased circulating total iga", "Decreased circulating total igg", "Decreased circulating total igm", "Decreased corneal reflex", "Decreased facial expression", "Decreased fertility", "Decreased fertility in females", "Decreased fertility in males", "Decreased head circumference", "Decreased lacrimation", "Decreased ldl cholesterol concentration", "Decreased libido", "Decreased light and dark adapted electroretinogram amplitude", "Decreased lymphocyte apoptosis", "Decreased lymphocyte proliferation in response to mitogen", "Decreased methylcobalamin", "Decreased methylmalonyl coa mutase activity", "Decreased muscle mass", "Decreased nasal nitric oxide", "Decreased number of large peripheral myelinated nerve fibers", "Decreased number of peripheral myelinated nerve fibers", "Decreased palmar creases", "Decreased patellar reflex", "Decreased plasma carnitine", "Decreased proportion of cd3 positive t cells", "Decreased proportion of cd4 positive helper t cells", "Decreased pulmonary function", "Decreased serum complement c3", "Decreased serum insulin like growth factor 1", "Decreased serum iron", "Decreased size of nerve terminals", "Decreased specific anti polysaccharide antibody level", "Decreased specific antibody response to protein vaccine", "Decreased specific antibody response to vaccination", "Decreased specific pneumococcal antibody level", "Decreased testicular size", "Decreased urine output", "Deep palmar crease", "Deep philtrum", "Deep plantar creases", "Deep set nails", "Deep venous thrombosis", "Deeply set eye", "Defective dna repair after ultraviolet radiation damage", "Defective t cell proliferation", "Deformed rib cage", "Deformed sella turcica", "Deformed tarsal bones", "Degeneration of the lateral corticospinal tracts", "Degeneration of the striatum", "Dehydration", "Delayed ability to roll over", "Delayed ability to sit", "Delayed ability to stand", "Delayed ability to walk", "Delayed closure of the anterior fontanelle", "Delayed cns myelination", "Delayed cranial suture closure", "Delayed epiphyseal ossification", "Delayed eruption of permanent teeth", "Delayed eruption of primary teeth", "Delayed eruption of teeth", "Delayed fine motor development", "Delayed gross motor development", "Delayed menarche", "Delayed myelination", "Delayed ossification of carpal bones", "Delayed proximal femoral epiphyseal ossification", "Delayed puberty", "Delayed social development", "Delirium", "Delusions", "Dementia", "Demyelinating peripheral neuropathy", "Dental crowding", "Dental malocclusion", "Depletion of mitochondrial dna in muscle tissue", "Deposits immunoreactive to beta amyloid protein", "Depressed nasal bridge", "Depressed nasal ridge", "Depressed nasal tip", "Depression", "Dermal atrophy", "Dermal translucency", "Dermatological manifestations of systemic disorders", "Dermoid cyst", "Descending aortic dissection", "Desquamation of skin soon after birth", "Developmental cataract", "Developmental glaucoma", "Developmental regression", "Developmental stagnation", "Deviated nasal septum", "Deviation of the 2nd finger", "Deviation of the 3rd finger", "Deviation of the hallux", "Deviation of the hand or of fingers of the hand", "Deviation of the thumb", "Deviation of toes", "Diabetes insipidus", "Dialeptic seizure", "Diaphragmatic eventration", "Diaphragmatic paralysis", "Diaphragmatic weakness", "Diaphyseal sclerosis", "Diaphyseal thickening", "Diarrhea", "Diastasis recti", "Diastema", "Dicarboxylic aciduria", "Difficulty climbing stairs", "Difficulty in tongue movements", "Difficulty running", "Difficulty standing", "Difficulty walking", "Diffuse alveolar hemorrhage", "Diffuse cerebellar atrophy", "Diffuse cerebral atrophy", "Diffuse mesangial sclerosis", "Diffuse optic disc pallor", "Diffuse white matter abnormalities", "Digenic inheritance", "Dilatation of the cerebral artery", "Dilatation of the ventricular cavity", "Dilated cardiomyopathy", "Dilated fourth ventricle", "Dilated third ventricle", "Dilation of lateral ventricles", "Dilation of virchow robin spaces", "Diminished ability to concentrate", "Diminished motivation", "Diminished movement", "Dimple chin", "Diplopia", "Disinhibition", "Displacement of the urethral meatus", "Disproportionate short limb short stature", "Disproportionate short stature", "Disproportionate short trunk short stature", "Disproportionate tall stature", "Disseminated intravascular coagulation", "Distal amyotrophy", "Distal arthrogryposis", "Distal joint laxity", "Distal lower limb amyotrophy", "Distal lower limb muscle weakness", "Distal muscle weakness", "Distal peripheral sensory neuropathy", "Distal sensory impairment", "Distal sensory impairment of all modalities", "Distal sensory loss of all modalities", "Distal upper limb amyotrophy", "Distal upper limb muscle weakness", "Disturbance of facial expression", "Dolichocephaly", "Down sloping shoulders", "Downslanted palpebral fissures", "Downturned corners of mouth", "Drowsiness", "Drusen", "Dry hair", "Dry skin", "Duodenal adenocarcinoma", "Duodenal atresia", "Duodenal stenosis", "Duplicated collecting system", "Duplication involving bones of the feet", "Duplication of hand bones", "Duplication of the distal phalanx of hand", "Duplication of thumb phalanx", "Dysarthria", "Dyscalculia", "Dyschromatopsia", "Dysdiadochokinesis", "Dysesthesia", "Dysgammaglobulinemia", "Dysgenesis of the cerebellar vermis", "Dysgenesis of the hippocampus", "Dysgerminoma", "Dysgraphia", "Dyskinesia", "Dyslexia", "Dysmenorrhea", "Dysmetria", "Dysmetric saccades", "Dysostosis multiplex", "Dyspareunia", "Dysphagia", "Dysphasia", "Dysphonia", "Dysplasia of the femoral head", "Dysplastic corpus callosum", "Dyspnea", "Dystonia", "Dystrophic fingernails", "Dystrophic toenail", "Dysuria", "Ear pain", "Early onset absence seizures", "Early onset of sexual maturation", "Easy fatigability", "Ecchymosis", "Echolalia", "Eclabion", "Eclampsia", "Ectodermal dysplasia", "Ectopia lentis", "Ectopia pupillae", "Ectopic anus", "Ectopic calcification", "Ectopic kidney", "Ectrodactyly", "Ectropion", "Ectropion of lower eyelids", "Eczema", "Eczematoid dermatitis", "Edema of the dorsum of feet", "Edema of the dorsum of hands", "Eeg with abnormally slow frequencies", "Eeg with burst suppression", "Eeg with continuous slow activity", "Eeg with focal epileptiform discharges", "Eeg with focal sharp slow waves", "Eeg with focal sharp waves", "Eeg with focal spike waves", "Eeg with focal spikes", "Eeg with frontal epileptiform discharges", "Eeg with generalized sharp slow waves", "Eeg with generalized slow activity", "Eeg with irregular generalized spike and wave complexes", "Eeg with multifocal slow activity", "Eeg with polyspike wave complexes", "Eeg with spike wave complexes", "Elbow ankylosis", "Elbow flexion contracture", "Elevated alkaline phosphatase of bone origin", "Elevated calcitonin", "Elevated circulating alanine aminotransferase concentration", "Elevated circulating aspartate aminotransferase concentration", "Elevated circulating follicle stimulating hormone level", "Elevated circulating glutaric acid concentration", "Elevated circulating growth hormone concentration", "Elevated circulating long chain fatty acid concentration", "Elevated circulating parathyroid hormone level", "Elevated circulating thyroid stimulating hormone concentration", "Elevated creatine kinase after exercise", "Elevated diastolic blood pressure", "Elevated gamma glutamyltransferase level", "Elevated hemoglobin a1c", "Elevated hepatic transaminase", "Elevated lactate pyruvate ratio", "Elevated mean arterial pressure", "Elevated proportion of cd4 negative cd8 negative alpha beta regulatory t cells", "Elevated pulmonary artery pressure", "Elevated serum acid phosphatase", "Elevated systolic blood pressure", "Elevated tissue non specific alkaline phosphatase", "Elevated urinary carboxylic acid", "Elevated urinary delta aminolevulinic acid", "Elevated urinary dicarboxylic acid level", "Elevated urinary monocarboxylic acid level", "Elfin facies", "Elliptocytosis", "Elongated superior cerebellar peduncle", "Embryonal neoplasm", "Embryonal renal neoplasm", "Emg abnormality", "Emg axonal abnormality", "Emg chronic denervation signs", "Emg decremental response of compound muscle action potential to repetitive nerve stimulation", "Emg impaired neuromuscular transmission", "Emg myopathic abnormalities", "Emg neuropathic changes", "Emg slow motor conduction", "Emotional lability", "Emphysema", "Enamel hypoplasia", "Encephalocele", "Encephalopathy", "Enchondroma", "Endocardial fibrosis", "Endocarditis", "Enlarged cerebellum", "Enlarged cisterna magna", "Enlarged joints", "Enlarged kidney", "Enlarged metaphyses", "Enlarged ovaries", "Enlarged posterior fossa", "Enlarged thorax", "Enlarged tonsils", "Enlargement of the costochondral junction", "Enlargement of the wrists", "Enterocolitis", "Enthesitis", "Entropion", "Enuresis", "Ependymoma", "Epicanthus", "Epicanthus inversus", "Epidermal acanthosis", "Epidermal hyperkeratosis", "Epidermal nevus", "Epidermoid cyst", "Epigastric pain", "Epileptic aura", "Epileptic encephalopathy", "Epileptic spasm", "Epiphora", "Epiphyseal dysplasia", "Epiphyseal stippling", "Epiretinal membrane", "Episodic ataxia", "Episodic hyperhidrosis", "Episodic hypertension", "Episodic pain", "Episodic respiratory distress", "Episodic tachypnea", "Episodic vomiting", "Epispadias", "Epistaxis", "Equinovarus deformity", "Equinus calcaneus", "Erectile dysfunction", "Erlenmeyer flask deformity of the femurs", "Eruption failure", "Erysipelas", "Erythema", "Erythema nodosum", "Erythematous papule", "Erythematous plaque", "Erythrocyte inclusion bodies", "Erythroderma", "Erythroid hyperplasia", "Erythroid hypoplasia", "Esodeviation", "Esophageal atresia", "Esophageal carcinoma", "Esophageal neoplasm", "Esophageal stenosis", "Esophageal stricture", "Esophageal varix", "Esophagitis", "Ethylmalonic aciduria", "Eunuchoid habitus", "Euryblepharon", "Eversion of lateral third of lower eyelids", "Everted upper lip vermilion", "Exaggerated cupid s bow", "Exaggerated startle response", "Exanthem", "Excessive daytime somnolence", "Excessive salivation", "Excessive wrinkled skin", "Excessive wrinkling of palmar skin", "Exercise induced muscle cramps", "Exercise induced muscle fatigue", "Exercise induced muscle stiffness", "Exercise induced myalgia", "Exercise induced myoglobinuria", "Exercise induced rhabdomyolysis", "Exercise intolerance", "Exertional dyspnea", "Exodeviation", "Exostoses", "Expressive aphasia", "Expressive language delay", "External ear malformation", "External genital hypoplasia", "External ophthalmoplegia", "Extra axial cerebrospinal fluid accumulation", "Extrahepatic cholestasis", "Extramedullary hematopoiesis", "Extrapyramidal dyskinesia", "Extrapyramidal muscular rigidity", "Eyelid coloboma", "Eyelid myoclonus", "Facial asymmetry", "Facial capillary hemangioma", "Facial cleft", "Facial diplegia", "Facial edema", "Facial erythema", "Facial grimacing", "Facial hemangioma", "Facial hyperostosis", "Facial hypertrichosis", "Facial hypotonia", "Facial myokymia", "Facial paralysis", "Facial shape deformation", "Facial telangiectasia", "Failure of eruption of permanent teeth", "Failure to thrive", "Failure to thrive in infancy", "Fair hair", "Falls", "Fasciculations", "Fasting hyperinsulinemia", "Fasting hypoglycemia", "Fat malabsorption", "Fatigable weakness of bulbar muscles", "Fatigable weakness of distal limb muscles", "Fatigable weakness of respiratory muscles", "Fatigable weakness of skeletal muscles", "Fatigable weakness of swallowing muscles", "Fatiguable weakness of proximal limb muscles", "Fatigue", "Fatty replacement of skeletal muscle", "Feeding difficulties", "Feeding difficulties in infancy", "Female external genitalia in individual with 46 xy karyotype", "Female hypogonadism", "Female infertility", "Female pseudohermaphroditism", "Female reproductive system neoplasm", "Female sexual dysfunction", "Femoral bowing", "Femoral hernia", "Fetal akinesia sequence", "Fetal distress", "Fetal onset", "Fetal polyuria", "Fetal ultrasound soft marker", "Fever", "Fibroadenoma of the breast", "Fibrosarcoma", "Fibrous tissue neoplasm", "Fibular aplasia", "Fibular hypoplasia", "Fine hair", "Finger agnosia", "Finger clinodactyly", "Finger swelling", "Finger syndactyly", "Fingernail dysplasia", "Fingerprint intracellular accumulation of autofluorescent lipopigment storage material", "First degree atrioventricular block", "First dorsal interossei muscle weakness", "Flank pain", "Flared iliac wing", "Flared metaphysis", "Flared nostrils", "Flaring of rib cage", "Flat acetabular roof", "Flat cornea", "Flat face", "Flat forehead", "Flat nasal alae", "Flat occiput", "Flattened epiphysis", "Flattened femoral epiphysis", "Flattened femoral head", "Flexion contracture of digit", "Flexion contracture of thumb", "Fluctuations in consciousness", "Flushing", "Foam cells", "Focal autonomic seizure", "Focal aware seizure", "Focal cognitive seizure with deja vu jamais vu", "Focal cortical dysplasia", "Focal cortical dysplasia type ii", "Focal dystonia", "Focal emotional seizure", "Focal impaired awareness seizure", "Focal motor seizure", "Focal motor status epilepticus", "Focal myoclonic seizure", "Focal non motor seizure", "Focal onset seizure", "Focal segmental glomerulosclerosis", "Focal sensory seizure", "Focal t2 hyperintense basal ganglia lesion", "Focal t2 hyperintense brainstem lesion", "Focal tonic seizure", "Focal white matter lesions", "Follicular hyperkeratosis", "Follicular hyperplasia", "Follicular thyroid carcinoma", "Food allergy", "Food intolerance", "Foot acroosteolysis", "Foot dorsiflexor weakness", "Foot oligodactyly", "Fractures of the long bones", "Fragile nails", "Fragile skin", "Fragmented epiphyses", "Freckling", "Frequent falls", "Frontal balding", "Frontal cortical atrophy", "Frontal hirsutism", "Frontal lobe dementia", "Frontotemporal cerebral atrophy", "Frontotemporal dementia", "Full cheeks", "Fulminant hepatic failure", "Functional abnormality of male internal genitalia", "Functional abnormality of the gastrointestinal tract", "Functional abnormality of the inner ear", "Functional abnormality of the middle ear", "Functional intestinal obstruction", "Functional motor deficit", "Furrowed tongue", "Fused cervical vertebrae", "Fusion of the cerebellar hemispheres", "Gait ataxia", "Gait disturbance", "Gait imbalance", "Galactorrhea", "Gangrene", "Gastric ulcer", "Gastritis", "Gastroesophageal reflux", "Gastrointestinal atresia", "Gastrointestinal carcinoma", "Gastrointestinal hemorrhage", "Gastrointestinal infarctions", "Gastrointestinal inflammation", "Gastrointestinal obstruction", "Gastrointestinal stroma tumor", "Gastroparesis", "Gastrostomy tube feeding in infancy", "Gaze evoked nystagmus", "Generalized abnormality of skin", "Generalized aminoaciduria", "Generalized amyotrophy", "Generalized clonic seizure", "Generalized dystonia", "Generalized edema", "Generalized hirsutism", "Generalized hyperkeratosis", "Generalized hyperpigmentation", "Generalized hyperreflexia", "Generalized hypertrichosis", "Generalized hypopigmentation", "Generalized hypopigmentation of hair", "Generalized hypotonia", "Generalized joint laxity", "Generalized limb muscle atrophy", "Generalized lipodystrophy", "Generalized lymphadenopathy", "Generalized muscle weakness", "Generalized myoclonic atonic seizure", "Generalized myoclonic seizure", "Generalized neonatal hypotonia", "Generalized onset motor seizure", "Generalized onset seizure", "Generalized osteoporosis", "Generalized osteosclerosis", "Generalized tonic seizure", "Genetic anticipation", "Genital neoplasm", "Genu valgum", "Genu varum", "Geographic atrophy", "Germ cell neoplasia", "Germinoma", "Giant platelets", "Giant somatosensory evoked potentials", "Gingival bleeding", "Gingival fibromatosis", "Gingival overgrowth", "Gingival recession", "Gingivitis", "Glaucoma", "Glioblastoma multiforme", "Glioma", "Gliosis", "Global brain atrophy", "Glomerular deposits", "Glomerular sclerosis", "Glomerulonephritis", "Glomerulopathy", "Glomus jugular tumor", "Glossitis", "Glossoptosis", "Glucose intolerance", "Glutaric aciduria", "Glycosuria", "Goiter", "Gonadal dysgenesis", "Gonadal neoplasm", "Gonadoblastoma", "Gonosomal inheritance", "Gout", "Gowers sign", "Grammar specific speech disorder", "Granulocytopenia", "Granulomatosis", "Gray matter heterotopia", "Gynecomastia", "Hallucinations", "Hallux valgus", "Hamartoma", "Hamartoma of the eye", "Hamartoma of tongue", "Hamartomatous polyposis", "Hammertoe", "Hamstring contractures", "Hand apraxia", "Hand clenching", "Hand muscle weakness", "Hand oligodactyly", "Hand polydactyly", "Hand tremor", "Handgrip myotonia", "Happy demeanor", "Hashimoto thyroiditis", "Head banging", "Head titubation", "Head tremor", "Headache", "Heart block", "Heat intolerance", "Heinz bodies", "Hemangioblastoma", "Hemangiomatosis", "Hematemesis", "Hematological neoplasm", "Hemianopia", "Hemiatrophy", "Hemifacial spasm", "Hemihypertrophy", "Hemimegalencephaly", "Hemiparesis", "Hemiplegia hemiparesis", "Hemivertebrae", "Hemoglobinuria", "Hemolytic anemia", "Hemolytic uremic syndrome", "Hemoptysis", "Hemorrhage of the eye", "Heparan sulfate excretion in urine", "Hepatic cysts", "Hepatic encephalopathy", "Hepatic failure", "Hepatic fibrosis", "Hepatic necrosis", "Hepatitis", "Hepatoblastoma", "Hepatocellular adenoma", "Hepatocellular carcinoma", "Hepatomegaly", "Hepatosplenomegaly", "Hereditary nonpolyposis colorectal carcinoma", "Hernia", "Herpes simplex encephalitis", "Heterochromia iridis", "Heterogeneous", "Heteronymous hemianopia", "Heterotaxy", "Heterotropia", "Hiatus hernia", "High anterior hairline", "High forehead", "High frequency hearing impairment", "High frequency sensorineural hearing impairment", "High hypermetropia", "High myopia", "High narrow palate", "High palate", "High pitched voice", "Highly arched eyebrow", "Hip contracture", "Hip dislocation", "Hip dysplasia", "Hip flexor weakness", "Hip osteoarthritis", "Hip pain", "Hip subluxation", "Hirsutism", "Hoarse cry", "Hoarse voice", "Hodgkin lymphoma", "Holoprosencephaly", "Homocystinuria", "Honeycomb lung", "Horizontal eyebrow", "Horizontal nystagmus", "Horizontal pendular nystagmus", "Horizontal ribs", "Horseshoe kidney", "Humeroradial synostosis", "Hydranencephaly", "Hydrocele testis", "Hydrocephalus", "Hydrops fetalis", "Hydroureter", "Hydroxyprolinuria", "Hyperactive deep tendon reflexes", "Hyperactive patellar reflex", "Hyperactivity", "Hyperacusis", "Hyperaldosteronism", "Hyperammonemia", "Hyperautofluorescent retinal lesion", "Hypercalcemia", "Hyperchloremic acidosis", "Hypercholesterolemia", "Hypercoagulability", "Hyperconvex fingernails", "Hyperconvex nail", "Hyperesthesia", "Hyperextensibility at wrists", "Hyperextensibility of the finger joints", "Hyperextensible skin", "Hypergalactosemia", "Hyperglycemia", "Hypergonadotropic hypogonadism", "Hypergranulosis", "Hyperhidrosis", "Hyperhomocystinemia", "Hyperinsulinemic hypoglycemia", "Hyperintensity of cerebral white matter on mri", "Hyperkalemia", "Hyperkeratosis", "Hyperkeratotic papule", "Hyperketonemia", "Hyperkinetic movements", "Hyperlipidemia", "Hyperlipoproteinemia", "Hyperlordosis", "Hypermagnesemia", "Hypermethioninemia", "Hypermetric saccades", "Hypermetropia", "Hypernatriuria", "Hyperorality", "Hyperostosis", "Hyperoxaluria", "Hyperparathyroidism", "Hyperphenylalaninemia", "Hyperphosphatemia", "Hyperphosphaturia", "Hyperpigmentation in sun exposed areas", "Hyperpigmentation of the skin", "Hyperpituitarism", "Hyperplasia of the maxilla", "Hyperreflexia", "Hyperreflexia in upper limbs", "Hypersomnia", "Hypersplenism", "Hypertelorism", "Hypertension associated with pheochromocytoma", "Hypertensive crisis", "Hyperthyroidism", "Hypertonia", "Hypertrichosis", "Hypertriglyceridemia", "Hypertrophic cardiomyopathy", "Hypertrophic nerve changes", "Hyperuricemia", "Hyperuricosuria", "Hyperventilation", "Hypoamylasemia", "Hypoautofluorescent retinal lesion", "Hypocalcemia", "Hypocalcemic seizures", "Hypocalcemic tetany", "Hypocalciuria", "Hypochloremia", "Hypocholesterolemia", "Hypochromia", "Hypochromic anemia", "Hypochromic microcytic anemia", "Hypodontia", "Hypoglycemic coma", "Hypoglycemic seizures", "Hypogonadism", "Hypogonadotropic hypogonadism", "Hypohidrosis", "Hypointensity of cerebral white matter on mri", "Hypokalemia", "Hypokalemic alkalosis", "Hypokalemic metabolic alkalosis", "Hypoketotic hypoglycemia", "Hypokinesia", "Hypolipidemia", "Hypolipoproteinemia", "Hypomelanotic macule", "Hypomethioninemia", "Hypometric saccades", "Hypomimic face", "Hypoparathyroidism", "Hypophosphatemia", "Hypophosphatemic rickets", "Hypopigmentation of the fundus", "Hypopigmentation of the skin", "Hypopigmented macule", "Hypopigmented skin patches", "Hypopituitarism", "Hypoplasia of olfactory tract", "Hypoplasia of penis", "Hypoplasia of teeth", "Hypoplasia of the brainstem", "Hypoplasia of the corpus callosum", "Hypoplasia of the ear cartilage", "Hypoplasia of the epiglottis", "Hypoplasia of the femoral head", "Hypoplasia of the fovea", "Hypoplasia of the frontal lobes", "Hypoplasia of the iris", "Hypoplasia of the musculature", "Hypoplasia of the odontoid process", "Hypoplasia of the olfactory bulb", "Hypoplasia of the pons", "Hypoplasia of the radius", "Hypoplasia of the uterus", "Hypoplasia of the vagina", "Hypoplasia of the ventral pons", "Hypoplastic anemia", "Hypoplastic aortic arch", "Hypoplastic cervical vertebrae", "Hypoplastic dermoepidermal hemidesmosomes", "Hypoplastic facial bones", "Hypoplastic female external genitalia", "Hypoplastic fifth fingernail", "Hypoplastic fifth toenail", "Hypoplastic fingernail", "Hypoplastic frontal sinuses", "Hypoplastic heart", "Hypoplastic helices", "Hypoplastic hippocampus", "Hypoplastic ilia", "Hypoplastic iliac wing", "Hypoplastic labia majora", "Hypoplastic labia minora", "Hypoplastic nipples", "Hypoplastic pelvis", "Hypoplastic pubic rami", "Hypoplastic toenails", "Hypoplastic vertebral bodies", "Hypoproteinemia", "Hyporeflexia", "Hyporeflexia of lower limbs", "Hyporeflexia of upper limbs", "Hyposmia", "Hypotelorism", "Hypotension", "Hypothalamic gonadotropin releasing hormone deficiency", "Hypothalamic hamartoma", "Hypothalamic hypothyroidism", "Hypothermia", "Hypotriglyceridemia", "Hypouricemia", "Hypoventilation", "Hypovolemic shock", "Hypsarrhythmia", "Ichthyosis", "Ileus", "Immotile cilia", "Immotile sperm", "Immune dysregulation", "Immunodeficiency", "Immunologic hypersensitivity", "Impacted tooth", "Impaired adp induced platelet aggregation", "Impaired antigen specific response", "Impaired collagen induced platelet aggregation", "Impaired distal proprioception", "Impaired distal tactile sensation", "Impaired distal vibration sensation", "Impaired epinephrine induced platelet aggregation", "Impaired glucose tolerance", "Impaired horizontal smooth pursuit", "Impaired mastication", "Impaired neutrophil bactericidal activity", "Impaired oropharyngeal swallow response", "Impaired pain sensation", "Impaired proprioception", "Impaired renal concentrating ability", "Impaired smooth pursuit", "Impaired social interactions", "Impaired t cell function", "Impaired tactile sensation", "Impaired tandem gait", "Impaired temperature sensation", "Impaired use of nonverbal behaviors", "Impaired vibration sensation at ankles", "Impaired vibration sensation in the lower limbs", "Impaired vibratory sensation", "Impaired visuospatial constructive cognition", "Impairment in personality functioning", "Impairment of activities of daily living", "Impotence", "Inability to walk", "Inappropriate antidiuretic hormone secretion", "Inappropriate behavior", "Inappropriate crying", "Inappropriate laughter", "Inappropriate sexual behavior", "Incisor macrodontia", "Incomitant strabismus", "Incomplete partition of the cochlea type ii", "Incomplete penetrance", "Incomprehensible speech", "Incoordination", "Increased adipose tissue", "Increased arm span", "Increased aspartate family amino acid level in urine", "Increased b cell count", "Increased blood pressure", "Increased blood urea nitrogen", "Increased body mass index", "Increased body weight", "Increased bone mineral density", "Increased c peptide level", "Increased cerebral lipofuscin", "Increased circulating acth level", "Increased circulating androgen concentration", "Increased circulating antibody level", "Increased circulating cortisol level", "Increased circulating gonadotropin level", "Increased circulating iga level", "Increased circulating igg level", "Increased circulating igm level", "Increased circulating lactate dehydrogenase concentration", "Increased circulating prolactin concentration", "Increased circulating renin level", "Increased connective tissue", "Increased csf lactate", "Increased density of long bones", "Increased endomysial connective tissue", "Increased fecal porphyrin", "Increased female libido", "Increased head circumference", "Increased hepatic glycogen content", "Increased hepatocellular lipid droplets", "Increased intracranial pressure", "Increased intramyocellular lipid droplets", "Increased laxity of ankles", "Increased ldl cholesterol concentration", "Increased level of hippuric acid in urine", "Increased level of l fucose in urine", "Increased mean corpuscular hemoglobin concentration", "Increased mean corpuscular volume", "Increased megakaryocyte count", "Increased muscle fatiguability", "Increased muscle glycogen content", "Increased muscle lipid content", "Increased nuchal translucency", "Increased overbite", "Increased proteinogenic amino acid level in urine", "Increased sensitivity to ionizing radiation", "Increased serine family amino acid in urine", "Increased serum iron", "Increased serum lactate", "Increased serum pyruvate", "Increased serum serotonin", "Increased serum testosterone level", "Increased skull ossification", "Increased sulfur amino acid level in urine", "Increased susceptibility to fractures", "Increased theta frequency activity in eeg", "Increased total bilirubin", "Increased urinary cortisol level", "Increased urinary non proteinogenic amino acid level", "Increased urine alpha ketoglutarate concentration", "Increased urine proteinogenic amino acid derivative level", "Increased vertebral height", "Ineffective esophageal peristalsis", "Infantile axial hypotonia", "Infantile encephalopathy", "Infantile muscular hypotonia", "Infantile onset", "Infantile spasms", "Infection related seizure", "Infectious encephalitis", "Inferior lens subluxation", "Inferior vermis hypoplasia", "Infertility", "Inflammation of the large intestine", "Inflammatory abnormality of the eye", "Inflexible adherence to routines or rituals", "Inguinal freckling", "Inguinal hernia", "Insidious onset", "Insomnia", "Inspiratory stridor", "Insulin resistance", "Insulin resistant diabetes mellitus", "Intellectual disability borderline", "Intellectual disability mild", "Intellectual disability moderate", "Intellectual disability profound", "Intellectual disability progressive", "Intellectual disability severe", "Intercostal muscle weakness", "Interictal eeg abnormality", "Intermittent diarrhea", "Intermittent episodes of respiratory insufficiency due to muscle weakness", "Internally nucleated skeletal muscle fibers", "Interrupted aortic arch", "Interstitial cardiac fibrosis", "Interstitial pneumonitis", "Intestinal atresia", "Intestinal fistula", "Intestinal hypoplasia", "Intestinal malrotation", "Intestinal polyp", "Intestinal pseudo obstruction", "Intraalveolar phospholipid accumulation", "Intracellular accumulation of autofluorescent lipopigment storage material", "Intracranial hemorrhage", "Intracranial meningioma", "Intractable diarrhea", "Intrauterine growth retardation", "Intrinsic hand muscle atrophy", "Intussusception", "Inverted nipples", "Involuntary movements", "Iris atrophy", "Iris coloboma", "Iris hypopigmentation", "Iron accumulation in brain", "Iron accumulation in globus pallidus", "Iron deficiency anemia", "Irregular capital femoral epiphysis", "Irregular epiphyses", "Irregular femoral epiphysis", "Irregular hyperpigmentation", "Irregular iliac crest", "Irregular menstruation", "Irregular vertebral endplates", "Irritability", "Ischemic stroke", "J shaped sella turcica", "Jaundice", "Jerky head movements", "Jerky ocular pursuit movements", "Joint contracture of the 5th finger", "Joint contracture of the hand", "Joint contractures involving the joints of the feet", "Joint dislocation", "Joint hemorrhage", "Joint hyperflexibility", "Joint hypermobility", "Joint laxity", "Joint stiffness", "Joint subluxation", "Joint swelling", "Juvenile aseptic necrosis", "Juvenile cataract", "Juvenile myelomonocytic leukemia", "Juvenile onset", "Juvenile rheumatoid arthritis", "Keloids", "Keratitis", "Keratoconjunctivitis", "Keratosis pilaris", "Ketoacidosis", "Ketonuria", "Ketosis", "Ketotic hypoglycemia", "Kinetic tremor", "Knee clonus", "Knee dislocation", "Knee flexion contracture", "Kyphoscoliosis", "Kyphosis", "Labial hypertrophy", "Lack of insight", "Lack of peer relationships", "Lack of skin elasticity", "Lack of t cell function", "Lacrimal duct stenosis", "Lacrimation abnormality", "Lactic acidosis", "Lacticaciduria", "Lactose intolerance", "Lagopthalmos", "Lambdoidal craniosynostosis", "Language impairment", "Large basal ganglia", "Large beaked nose", "Large earlobe", "Large face", "Large fleshy ears", "Large for gestational age", "Large foramen magnum", "Large forehead", "Large hands", "Large iliac wing", "Large intestinal polyposis", "Large placenta", "Large sella turcica", "Laryngeal cleft", "Laryngeal dystonia", "Laryngeal hypoplasia", "Laryngeal stenosis", "Laryngeal stridor", "Laryngomalacia", "Laryngotracheomalacia", "Late onset", "Lateral clavicle hook", "Leber optic atrophy", "Left atrial enlargement", "Left bundle branch block", "Left to right shunt", "Left ventricular hypertrophy", "Left ventricular noncompaction cardiomyopathy", "Left ventricular outflow tract obstruction", "Left ventricular systolic dysfunction", "Leg muscle stiffness", "Leiomyosarcoma", "Lens subluxation", "Lethal skeletal dysplasia", "Lethargy", "Leukemia", "Leukocytosis", "Leukodystrophy", "Leukoencephalopathy", "Leukonychia", "Leukopenia", "Lewy bodies", "Leydig cell neoplasia", "Lichenification", "Limb ataxia", "Limb dysmetria", "Limb dystonia", "Limb fasciculations", "Limb girdle muscle atrophy", "Limb girdle muscle weakness", "Limb girdle muscular dystrophy", "Limb hypertonia", "Limb joint contracture", "Limb muscle weakness", "Limb myoclonus", "Limb pain", "Limb tremor", "Limb undergrowth", "Limitation of joint mobility", "Limitation of knee mobility", "Limitation of movement at ankles", "Limitation of neck motion", "Limited elbow extension", "Limited elbow movement", "Limited extraocular movements", "Limited hip extension", "Limited hip movement", "Limited knee extension", "Limited wrist movement", "Lingual dystonia", "Lipid accumulation in hepatocytes", "Lipoatrophy", "Lipodystrophy", "Lipoma", "Lissencephaly", "Liver abscess", "Lobar holoprosencephaly", "Lobulated tongue", "Localized hirsutism", "Localized osteoporosis", "Localized skin lesion", "Long clavicles", "Long ear", "Long eyelashes", "Long fingers", "Long foot", "Long hallux", "Long neck", "Long nose", "Long palm", "Long palpebral fissure", "Long penis", "Long philtrum", "Long thorax", "Long toe", "Long tract signs", "Long upper lip", "Loss of ability to walk", "Loss of consciousness", "Loss of eyelashes", "Loss of purkinje cells in the cerebellar vermis", "Loss of speech", "Loss of subcutaneous adipose tissue in limbs", "Loss of voice", "Low alkaline phosphatase", "Low anterior hairline", "Low apgar score", "Low back pain", "Low frustration tolerance", "Low grade fever", "Low hanging columella", "Low levels of vitamin d", "Low molecular weight proteinuria", "Low plasma citrulline", "Low posterior hairline", "Low set nipples", "Low set posteriorly rotated ears", "Lower extremity joint dislocation", "Lower eyelid coloboma", "Lower limb amyotrophy", "Lower limb asymmetry", "Lower limb hyperreflexia", "Lower limb hypertonia", "Lower limb metaphyseal irregularity", "Lower limb muscle weakness", "Lower limb pain", "Lower limb spasticity", "Lower limb undergrowth", "Lumbar hyperlordosis", "Lumbar kyphosis", "Lumbar scoliosis", "Lung adenocarcinoma", "Lymphadenitis", "Lymphangiectasis", "Lymphangioma", "Lymphedema", "Lymphocytosis", "Lymphoma", "Lymphopenia", "Lymphoproliferative disorder", "Macrocephaly at birth", "Macrocytic anemia", "Macrodactyly", "Macrodontia", "Macrodontia of permanent maxillary central incisor", "Macroglossia", "Macrogyria", "Macroorchidism", "Macroscopic hematuria", "Macrotia", "Macrovesicular hepatic steatosis", "Macular atrophy", "Macular coloboma", "Macular degeneration", "Macular hyperpigmentation", "Macular hypoplasia", "Macular purpura", "Macular thickening", "Macule", "Malabsorption", "Malar prominence", "Male hypogonadism", "Male infertility", "Male pseudohermaphroditism", "Male reproductive system neoplasm", "Male sexual dysfunction", "Malignant genitourinary tract tumor", "Malignant hyperthermia", "Malignant neoplasm of the central nervous system", "Malnutrition", "Malrotation of small bowel", "Mandibular aplasia", "Mandibular prognathia", "Mania", "Mask like facies", "Mastoiditis", "Maternal diabetes", "Maternal hypertension", "Maturity onset diabetes of the young", "Meconium stained amniotic fluid", "Medial flaring of the eyebrow", "Median cleft lip", "Median cleft palate", "Mediastinal lymphadenopathy", "Medullary nephrocalcinosis", "Medulloblastoma", "Megalencephaly", "Megaloblastic anemia", "Megalocornea", "Melanocytic nevus", "Melanoma", "Melena", "Membranoproliferative glomerulonephritis", "Memory impairment", "Meningioma", "Meningitis", "Meningocele", "Menorrhagia", "Mental deterioration", "Mesoaxial hand polydactyly", "Mesoaxial polydactyly", "Mesomelia", "Metabolic acidosis", "Metabolic alkalosis", "Metacarpophalangeal joint contracture", "Metamorphopsia", "Metaphyseal chondrodysplasia", "Metaphyseal cupping", "Metaphyseal dysplasia", "Metaphyseal irregularity", "Metaphyseal sclerosis", "Metaphyseal striations", "Metaphyseal widening", "Metatarsal synostosis", "Metatarsus adductus", "Metatarsus valgus", "Methemoglobinemia", "Methylmalonic acidemia", "Methylmalonic aciduria", "Metopic synostosis", "Metrorrhagia", "Microcornea", "Microcytic anemia", "Microdontia", "Microglossia", "Micrographia", "Micromelia", "Micronodular cirrhosis", "Micropenis", "Microphallus", "Microretrognathia", "Microscopic hematuria", "Microtia third degree", "Microvesicular hepatic steatosis", "Middle age onset", "Midface retrusion", "Midline defect of the nose", "Migraine", "Mild global developmental delay", "Mild hearing impairment", "Mild microcephaly", "Mild postnatal growth retardation", "Mild short stature", "Mildly elevated creatine kinase", "Milia", "Minicore myopathy", "Minimal change glomerulonephritis", "Miosis", "Misalignment of incisors", "Missing ribs", "Mitochondrial inheritance", "Mitochondrial myopathy", "Mitochondrial respiratory chain defects", "Mitral stenosis", "Mitral valve calcification", "Mitral valve prolapse", "Mitten deformity", "Mixed demyelinating and axonal polyneuropathy", "Mixed hearing impairment", "Mixed hypo and hyperpigmentation of the skin", "Moderate albuminuria", "Moderate global developmental delay", "Moderate sensorineural hearing impairment", "Moderately reduced visual acuity", "Molar tooth sign on mri", "Molluscoid pseudotumors", "Molluscum contagiosum", "Monochromacy", "Monocytosis", "Monotonic speech", "Mood swings", "Morning glory anomaly", "Morning myoclonic jerks", "Morphological abnormality of the corticospinal tract", "Morphological abnormality of the middle ear", "Morphological abnormality of the pyramidal tract", "Morphological abnormality of the vestibule of the inner ear", "Mortality aging", "Motor axonal neuropathy", "Motor delay", "Motor deterioration", "Motor neuron atrophy", "Motor polyneuropathy", "Motor regression", "Motor seizure", "Motor tics", "Mottled pigmentation", "Movement abnormality of the tongue", "Moyamoya phenomenon", "Mucosal telangiectasiae", "Multicystic kidney dysplasia", "Multifactorial inheritance", "Multifocal cerebral white matter abnormalities", "Multifocal epileptiform discharges", "Multifocal seizures", "Multiple cafe au lait spots", "Multiple enchondromatosis", "Multiple exostoses", "Multiple gastric polyps", "Multiple glomerular cysts", "Multiple impacted teeth", "Multiple joint contractures", "Multiple joint dislocation", "Multiple lentigines", "Multiple lipomas", "Multiple mitochondrial dna deletions", "Multiple myeloma", "Multiple prenatal fractures", "Multiple renal cysts", "Multiple rib fractures", "Multiple rows of eyelashes", "Multiple suture craniosynostosis", "Muscle abnormality related to mitochondrial dysfunction", "Muscle fiber atrophy", "Muscle fiber inclusion bodies", "Muscle fiber necrosis", "Muscle fiber splitting", "Muscle fiber tubular inclusions", "Muscle fibrillation", "Muscle flaccidity", "Muscle hypertrophy of the lower extremities", "Muscle spasm", "Muscle stiffness", "Muscle weakness", "Muscular dystrophy", "Muscular hypotonia of the trunk", "Muscular ventricular septal defect", "Mutism", "Myalgia", "Mydriasis", "Myelodysplasia", "Myelofibrosis", "Myeloid leukemia", "Myelomeningocele", "Myelopathy", "Myeloproliferative disorder", "Myocardial fibrosis", "Myoclonic seizure", "Myoclonic spasms", "Myoclonus", "Myofibrillar myopathy", "Myoglobinuria", "Myokymia", "Myopathic facies", "Myopathy", "Myopia", "Myositis", "Myotonia", "Naevus flammeus of the eyelid", "Nail dysplasia", "Nail dystrophy", "Nail pits", "Narrow face", "Narrow foramen obturatorium", "Narrow forehead", "Narrow iliac wing", "Narrow internal auditory canal", "Narrow jaw", "Narrow mouth", "Narrow nasal bridge", "Narrow nasal ridge", "Narrow nose", "Narrow palate", "Narrow palm", "Narrow palpebral fissure", "Narrow pelvis bone", "Narrow vertebral interpedicular distance", "Nasal congestion", "Nasal regurgitation", "Nasal speech", "Nasogastric tube feeding", "Nasogastric tube feeding in infancy", "Nasolacrimal duct obstruction", "Natal tooth", "Nausea", "Nausea and vomiting", "Neck flexor weakness", "Neck muscle weakness", "Negativism", "Nemaline bodies", "Neonatal alloimmune thrombocytopenia", "Neonatal asphyxia", "Neonatal breathing dysregulation", "Neonatal death", "Neonatal hyperbilirubinemia", "Neonatal hypoglycemia", "Neonatal hypotonia", "Neonatal insulin dependent diabetes mellitus", "Neonatal onset", "Neonatal respiratory distress", "Neoplasm", "Neoplasm by histology", "Neoplasm of fatty tissue", "Neoplasm of head and neck", "Neoplasm of striated muscle", "Neoplasm of the adrenal cortex", "Neoplasm of the adrenal gland", "Neoplasm of the breast", "Neoplasm of the colon", "Neoplasm of the ear", "Neoplasm of the endocrine system", "Neoplasm of the eye", "Neoplasm of the gallbladder", "Neoplasm of the gastrointestinal tract", "Neoplasm of the genitourinary tract", "Neoplasm of the heart", "Neoplasm of the inner ear", "Neoplasm of the large intestine", "Neoplasm of the larynx", "Neoplasm of the liver", "Neoplasm of the male external genitalia", "Neoplasm of the middle ear", "Neoplasm of the nervous system", "Neoplasm of the oral cavity", "Neoplasm of the pancreas", "Neoplasm of the parathyroid gland", "Neoplasm of the peripheral nervous system", "Neoplasm of the pituitary gland", "Neoplasm of the rectum", "Neoplasm of the respiratory system", "Neoplasm of the skeletal system", "Neoplasm of the skin", "Neoplasm of the small intestine", "Neoplasm of the stomach", "Neoplasm of the thyroid gland", "Neoplasm of the tongue", "Neoplasm of the tracheobronchial system", "Nephritis", "Nephrocalcinosis", "Nephrogenic diabetes insipidus", "Nephrolithiasis", "Nephronophthisis", "Nephropathy", "Nephrotic syndrome", "Neuralgia", "Neurodegeneration", "Neuroendocrine neoplasm", "Neurofibrillary tangles", "Neurofibromas", "Neurogenic bladder", "Neuroinflammation", "Neuromuscular dysphagia", "Neuronal loss in basal ganglia", "Neuronal loss in central nervous system", "Neuronal loss in the cerebral cortex", "Neuropathic arthropathy", "Neutropenia in presence of anti neutropil antibodies", "Neutrophilia", "Nevus", "Night sweats", "No social interaction", "Nocturia", "Nocturnal hypoventilation", "Nocturnal seizures", "Non hodgkin lymphoma", "Non midline cleft lip", "Non midline cleft palate", "Non motor seizure", "Non obstructive azoospermia", "Noncompaction cardiomyopathy", "Nonimmune hydrops fetalis", "Nonketotic hypoglycemia", "Nonprogressive", "Nonprogressive cerebellar ataxia", "Nonprogressive encephalopathy", "Nonspherocytic hemolytic anemia", "Normochromic anemia", "Normocytic anemia", "Nuclear cataract", "Numerous nevi", "Numerous pigmented freckles", "Nyctalopia", "Nystagmus induced head nodding", "Obsessive compulsive behavior", "Obsessive compulsive trait", "Obstructive sleep apnea", "Occipital cortical atrophy", "Occipital encephalocele", "Occipital meningocele", "Ocular albinism", "Ocular anterior segment dysgenesis", "Ocular pain", "Oculogyric crisis", "Oculomotor apraxia", "Oculomotor nerve palsy", "Odontogenic neoplasm", "Oligoarthritis", "Oligodactyly", "Oligodontia", "Oligohydramnios", "Oligomenorrhea", "Oligosacchariduria", "Oligospermia", "Oliguria", "Olivopontocerebellar atrophy", "Olivopontocerebellar hypoplasia", "Omphalocele", "Onion bulb formation", "Onset", "Onychogryposis", "Onychogryposis of toenails", "Onycholysis", "Onychomycosis", "Open angle glaucoma", "Open bite", "Open mouth", "Open operculum", "Ophthalmoparesis", "Opisthotonus", "Opportunistic infection", "Opsoclonus", "Optic atrophy", "Optic disc coloboma", "Optic disc hypoplasia", "Optic disc pallor", "Optic nerve compression", "Optic nerve dysplasia", "Optic nerve hypoplasia", "Optic neuropathy", "Oral aversion", "Oral cavity bleeding", "Oral cleft", "Oral leukoplakia", "Oral mucosal blisters", "Oral pharyngeal dysphagia", "Oral ulcer", "Orchitis", "Organic aciduria", "Orofacial dyskinesia", "Oromandibular dystonia", "Oromotor apraxia", "Oroticaciduria", "Orthopnea", "Orthostatic hypotension", "Orthostatic hypotension due to autonomic dysfunction", "Osteoarthritis", "Osteochondroma", "Osteochondrosis", "Osteolysis", "Osteolysis involving bones of the feet", "Osteolysis involving bones of the upper limbs", "Osteolytic defects of the distal phalanges of the hand", "Osteomalacia", "Osteomyelitis", "Osteopenia", "Osteopetrosis", "Osteoporosis", "Osteosarcoma", "Otitis media", "Otosclerosis", "Oval face", "Ovarian carcinoma", "Ovarian cyst", "Ovarian gonadoblastoma", "Ovarian neoplasm", "Ovarian papillary adenocarcinoma", "Overfolding of the superior helices", "Overfriendliness", "Overgrowth", "Overhanging nasal tip", "Overlapping fingers", "Overlapping toe", "Overriding aorta", "Overtubulated long bones", "Overweight", "Ovoid vertebral bodies", "Ovotestis", "Pace of progression", "Pain", "Pain in head and neck region", "Pain insensitivity", "Painless fractures due to injury", "Pallor", "Palmar hyperhidrosis", "Palmar pits", "Palmar telangiectasia", "Palmoplantar blistering", "Palmoplantar cutis laxa", "Palmoplantar hyperhidrosis", "Palpebral edema", "Palpitations", "Pancreatic adenocarcinoma", "Pancreatic cysts", "Pancreatic fibrosis", "Pancreatic hypoplasia", "Pancreatic islet cell hyperplasia", "Pancreatitis", "Pancytopenia", "Panhypogammaglobulinemia", "Panhypopituitarism", "Panniculitis", "Papillary renal cell carcinoma", "Papillary thyroid carcinoma", "Papilledema", "Papilloma", "Papule", "Paracentral scotoma", "Paraganglioma", "Parakeratosis", "Paralysis", "Paranoia", "Paraparesis", "Paraplegia", "Paraplegia paraparesis", "Parasomnia", "Parathyroid adenoma", "Parathyroid carcinoma", "Paresthesia", "Parietal bossing", "Parietal foramina", "Parkinsonism", "Parkinsonism with favorable response to dopaminergic medication", "Paronychia", "Paroxysmal bursts of laughter", "Paroxysmal dystonia", "Paroxysmal involuntary eye movements", "Paroxysmal ventricular tachycardia", "Partial absence of thumb", "Partial agenesis of the corpus callosum", "Partial anomalous pulmonary venous return", "Partial duplication of the phalanx of hand", "Patchy alopecia", "Patchy changes of bone mineral density", "Patchy hypopigmentation of hair", "Patchy palmoplantar hyperkeratosis", "Patellar aplasia", "Patellar dislocation", "Patellar hypoplasia", "Patellar subluxation", "Patent ductus arteriosus", "Patent foramen ovale", "Pathologic fracture", "Pectus carinatum", "Pectus excavatum", "Pectus excavatum of inferior sternum", "Pedal edema", "Pediatric onset", "Pelvic girdle muscle weakness", "Pelvic kidney", "Pendular nystagmus", "Penetrating foot ulcers", "Peptic ulcer", "Periauricular skin pits", "Pericardial effusion", "Pericarditis", "Perifoveal ring of hyperautofluorescence", "Perimembranous ventricular septal defect", "Periodic paralysis", "Periodontitis", "Periorbital edema", "Periorbital fullness", "Peripheral arterial stenosis", "Peripheral axonal degeneration", "Peripheral axonal neuropathy", "Peripheral cyanosis", "Peripheral demyelination", "Peripheral edema", "Peripheral hypermyelination", "Peripheral hypomyelination", "Peripheral neuropathy", "Peripheral opacification of the cornea", "Peripheral pulmonary artery stenosis", "Peripheral retinal avascularization", "Peripheral visual field loss", "Periportal fibrosis", "Perisylvian polymicrogyria", "Peritoneal abscess", "Peritonitis", "Periventricular cysts", "Periventricular heterotopia", "Periventricular leukomalacia", "Periventricular nodular heterotopia", "Periventricular white matter hyperintensities", "Peroneal muscle atrophy", "Perseveration", "Persistence of hemoglobin f", "Persistence of primary teeth", "Persistent ebv viremia", "Persistent head lag", "Personality changes", "Pes cavus", "Pes planus", "Pes valgus", "Petechiae", "Peters anomaly", "Phalangeal dislocation", "Pharyngitis", "Phenotypic variability", "Pheochromocytoma", "Phimosis", "Phocomelia", "Phonophobia", "Photophobia", "Photopsia", "Photoreceptor layer loss on macular oct", "Phthisis bulbi", "Physical urticaria", "Pierre robin sequence", "Pigmentary retinopathy", "Pili canaliculi", "Pili torti", "Pilomatrixoma", "Pineal cyst", "Pituitary adenoma", "Pituitary growth hormone cell adenoma", "Pituitary hypothyroidism", "Pituitary prolactin cell adenoma", "Plagiocephaly", "Plantar hyperkeratosis", "Platybasia", "Platyspondyly", "Pleural effusion", "Pleuritis", "Pneumonia", "Pneumothorax", "Poikilocytosis", "Poikiloderma", "Pointed chin", "Polar cataract", "Pollakisuria", "Polyarticular arthropathy", "Polyclonal elevation of igm", "Polycystic kidney dysplasia", "Polycystic liver disease", "Polycythemia", "Polydactyly", "Polygenic inheritance", "Polyhydramnios", "Polymicrogyria", "Polyneuropathy", "Polyphagia", "Polysplenia", "Polyuria", "Pontocerebellar atrophy", "Poor appetite", "Poor coordination", "Poor eye contact", "Poor fine motor coordination", "Poor gross motor coordination", "Poor head control", "Poor motor coordination", "Poor speech", "Poor suck", "Poor wound healing", "Porencephalic cyst", "Porokeratosis", "Porphyrinuria", "Portal fibrosis", "Portal vein thrombosis", "Positional foot deformity", "Positive romberg sign", "Post partum hemorrhage", "Postaxial foot polydactyly", "Postaxial hand polydactyly", "Postaxial polydactyly", "Posterior blepharitis", "Posterior embryotoxon", "Posterior fossa cyst", "Posterior pharyngeal cleft", "Posterior pituitary dysgenesis", "Posterior polar cataract", "Posterior subcapsular cataract", "Posteriorly rotated ears", "Postexertional malaise", "Postnatal growth retardation", "Postural instability", "Postural tremor", "Potter facies", "Preauricular skin tag", "Preaxial foot polydactyly", "Preaxial hand polydactyly", "Preaxial polydactyly", "Precocious atherosclerosis", "Predominantly lower limb lymphedema", "Prelingual sensorineural hearing impairment", "Premature adrenarche", "Premature arteriosclerosis", "Premature birth", "Premature coronary artery atherosclerosis", "Premature graying of hair", "Premature loss of primary teeth", "Premature loss of teeth", "Premature osteoarthritis", "Premature ovarian insufficiency", "Premature pubarche", "Premature rupture of membranes", "Premature skin wrinkling", "Premature thelarche", "Premature ventricular contraction", "Prematurely aged appearance", "Prenatal maternal abnormality", "Prenatal movement abnormality", "Primary adrenal insufficiency", "Primary amenorrhea", "Primary congenital glaucoma", "Primary gonadal insufficiency", "Primary hypercortisolism", "Primary hyperparathyroidism", "Primary microcephaly", "Primary peritoneal carcinoma", "Primitive neuroectodermal tumor", "Primitive reflex", "Productive cough", "Profound global developmental delay", "Profound hearing impairment", "Profound sensorineural hearing impairment", "Progeroid facial appearance", "Progressive", "Progressive cerebellar ataxia", "Progressive distal muscle weakness", "Progressive encephalopathy", "Progressive external ophthalmoplegia", "Progressive extrapyramidal movement disorder", "Progressive flexion contractures", "Progressive gait ataxia", "Progressive hearing impairment", "Progressive inability to walk", "Progressive leukoencephalopathy", "Progressive macrocephaly", "Progressive microcephaly", "Progressive muscle weakness", "Progressive neurologic deterioration", "Progressive night blindness", "Progressive peripheral neuropathy", "Progressive pes cavus", "Progressive proximal muscle weakness", "Progressive psychomotor deterioration", "Progressive pulmonary function impairment", "Progressive sensorineural hearing impairment", "Progressive spastic paraparesis", "Progressive spastic paraplegia", "Progressive spastic quadriplegia", "Progressive spasticity", "Progressive visual field defects", "Progressive visual loss", "Prolinuria", "Prolonged bleeding following procedure", "Prolonged bleeding time", "Prolonged neonatal jaundice", "Prolonged partial thromboplastin time", "Prolonged qtc interval", "Prominent antihelix", "Prominent antitragus", "Prominent calcaneus", "Prominent crus of helix", "Prominent digit pad", "Prominent ear helix", "Prominent eyelashes", "Prominent forehead", "Prominent metopic ridge", "Prominent nasal bridge", "Prominent nasal tip", "Prominent nasolabial fold", "Prominent nose", "Prominent occiput", "Prominent sternum", "Prominent superficial blood vessels", "Prominent supraorbital ridges", "Prominent umbilicus", "Prominent veins on trunk", "Proportionate short stature", "Proportionate tall stature", "Proptosis", "Prostate neoplasm", "Protein avoidance", "Protein losing enteropathy", "Protracted diarrhea", "Protruding ear", "Protruding tongue", "Protrusio acetabuli", "Protuberant abdomen", "Proximal amyotrophy", "Proximal femoral epiphysiolysis", "Proximal femoral metaphyseal abnormality", "Proximal femoral metaphyseal irregularity", "Proximal muscle weakness", "Proximal muscle weakness in lower limbs", "Proximal muscle weakness in upper limbs", "Proximal renal tubular acidosis", "Proximal symphalangism", "Proximal tubulopathy", "Proximal upper limb amyotrophy", "Pruritus", "Pseudoarthrosis", "Pseudobulbar paralysis", "Pseudobulbar signs", "Pseudoepiphyses", "Pseudoepiphyses of hand bones", "Pseudoepiphyses of the metacarpals", "Pseudohypoaldosteronism", "Pseudohypoparathyroidism", "Psoriasiform dermatitis", "Psychic epileptic aura", "Psychogenic non epileptic seizure", "Psychomotor deterioration", "Psychomotor retardation", "Psychosis", "Psychotic episodes", "Psychotic mentation", "Pterygium", "Ptosis", "Puberty and gonadal disorders", "Pulmonary artery dilatation", "Pulmonary artery hypoplasia", "Pulmonary artery stenosis", "Pulmonary carcinoid tumor", "Pulmonary cyst", "Pulmonary edema", "Pulmonary embolism", "Pulmonary fibrosis", "Pulmonary hemorrhage", "Pulmonary hypoplasia", "Pulmonary infiltrates", "Pulmonary insufficiency", "Pulmonary interstitial high resolution computed tomography abnormality", "Pulmonary venous hypertension", "Pulmonic stenosis", "Pulverulent cataract", "Punctate cataract", "Pure red cell aplasia", "Purpura", "Pustule", "Pyelonephritis", "Pyoderma gangrenosum", "Pyridoxine responsive sideroblastic anemia", "Quadriceps muscle weakness", "Radial bowing", "Radial deviation of the 2nd finger", "Radial deviation of the hand", "Radial deviation of the hand or of fingers of the hand", "Radioulnar dislocation", "Radioulnar synostosis", "Ragged red muscle fibers", "Rapidly progressive", "Raynaud phenomenon", "Reactive hypoglycemia", "Receptive language delay", "Rectal abscess", "Rectal fistula", "Rectal prolapse", "Recurrent", "Recurrent abscess formation", "Recurrent acute respiratory tract infection", "Recurrent aspergillus infections", "Recurrent aspiration pneumonia", "Recurrent bacterial infections", "Recurrent bacterial skin infections", "Recurrent bronchitis", "Recurrent bronchopulmonary infections", "Recurrent corneal erosions", "Recurrent cutaneous abscess formation", "Recurrent ear infections", "Recurrent fever", "Recurrent fractures", "Recurrent gastroenteritis", "Recurrent hand flapping", "Recurrent herpes", "Recurrent hypoglycemia", "Recurrent infection of the gastrointestinal tract", "Recurrent joint dislocation", "Recurrent lower respiratory tract infections", "Recurrent mycobacterial infections", "Recurrent opportunistic infections", "Recurrent otitis media", "Recurrent pancreatitis", "Recurrent paroxysmal headache", "Recurrent pharyngitis", "Recurrent pneumonia", "Recurrent respiratory infections", "Recurrent sinopulmonary infections", "Recurrent sinusitis", "Recurrent skin infections", "Recurrent staphylococcal infections", "Recurrent staphylococcus aureus infections", "Recurrent upper and lower respiratory tract infections", "Recurrent urinary tract infections", "Recurrent viral infections", "Red eye", "Red green dyschromatopsia", "Red hair", "Reduced antigen specific t cell proliferation", "Reduced antithrombin iii activity", "Reduced brain n acetyl aspartate level by mrs", "Reduced c peptide level", "Reduced circulating prolactin concentration", "Reduced consciousness confusion", "Reduced delayed hypersensitivity", "Reduced factor xi activity", "Reduced factor xii activity", "Reduced factor xiii activity", "Reduced forced expiratory volume in one second", "Reduced forced vital capacity", "Reduced natural killer cell count", "Reduced pancreatic beta cells", "Reduced protein c activity", "Reduced protein s activity", "Reduced renal corticomedullary differentiation", "Reduced sperm motility", "Reduced subcutaneous adipose tissue", "Reduced systolic function", "Reduced tendon reflexes", "Reduced visual acuity", "Reduced vital capacity", "Reduction of neutrophil motility", "Redundant neck skin", "Redundant skin", "Refractory anemia", "Regional abnormality of skin", "Relative macrocephaly", "Renal agenesis", "Renal angiomyolipoma", "Renal cell carcinoma", "Renal cortical cysts", "Renal cortical microcysts", "Renal corticomedullary cysts", "Renal cyst", "Renal duplication", "Renal dysplasia", "Renal fanconi syndrome", "Renal fibrosis", "Renal hamartoma", "Renal hypoplasia", "Renal hypoplasia aplasia", "Renal insufficiency", "Renal magnesium wasting", "Renal malrotation", "Renal phosphate wasting", "Renal potassium wasting", "Renal salt wasting", "Renal steatosis", "Renal tubular acidosis", "Renal tubular atrophy", "Renal tubular dysfunction", "Renal tubular epithelial necrosis", "Renovascular hypertension", "Repetitive compulsive behavior", "Respiratory alkalosis", "Respiratory arrest", "Respiratory distress", "Respiratory failure", "Respiratory failure requiring assisted ventilation", "Respiratory insufficiency", "Respiratory insufficiency due to defective ciliary clearance", "Respiratory paralysis", "Respiratory tract infection", "Response to drugs acting on neuromuscular transmission", "Resting tremor", "Restless legs", "Restlessness", "Restrictive behavior", "Restrictive cardiomyopathy", "Restrictive ventilatory defect", "Reticular hyperpigmentation", "Reticulated skin pigmentation", "Reticulocytopenia", "Reticulocytosis", "Retinal arterial tortuosity", "Retinal arteriolar tortuosity", "Retinal atrophy", "Retinal coloboma", "Retinal degeneration", "Retinal detachment", "Retinal dysplasia", "Retinal dystrophy", "Retinal fold", "Retinal hamartoma", "Retinal hemorrhage", "Retinal neovascularization", "Retinal perforation", "Retinal pigment epithelial atrophy", "Retinal pigment epithelial mottling", "Retinal telangiectasia", "Retinal thinning", "Retinal vascular tortuosity", "Retinopathy", "Retrocollis", "Retrognathia", "Rhabdomyolysis", "Rhabdomyosarcoma", "Rhegmatogenous retinal detachment", "Rheumatoid arthritis", "Rheumatoid factor positive", "Rhinitis", "Rhizomelia", "Rhizomelic arm shortening", "Rib fusion", "Rib segmentation abnormalities", "Rickets", "Ridged fingernail", "Ridged nail", "Rieger anomaly", "Right bundle branch block", "Right ventricular cardiomyopathy", "Right ventricular dilatation", "Right ventricular hypertrophy", "Rigidity", "Rimmed vacuoles", "Rod cone dystrophy", "Rotary nystagmus", "Round ear", "Round face", "Saccadic oscillation", "Saccadic smooth pursuit", "Sacrococcygeal teratoma", "Sagittal craniosynostosis", "Sandal gap", "Sarcoma", "Scaling skin", "Scanning speech", "Scaphocephaly", "Scapular winging", "Scarring", "Scarring alopecia of scalp", "Schistocytosis", "Schizencephaly", "Schizophrenia", "Schwannoma", "Scleral staphyloma", "Sclerocornea", "Scleroderma", "Sclerosis of hand bone", "Sclerosis of skull base", "Sclerotic vertebral endplates", "Scotoma", "Scrotal hypoplasia", "Sea blue histiocytosis", "Seborrheic dermatitis", "Second degree atrioventricular block", "Secondary amenorrhea", "Secondary growth hormone deficiency", "Secondary microcephaly", "Secretory diarrhea", "Secundum atrial septal defect", "Segmental peripheral demyelination remyelination", "Selective tooth agenesis", "Self injurious behavior", "Self mutilation", "Semilobar holoprosencephaly", "Senile plaques", "Sensorimotor neuropathy", "Sensory ataxia", "Sensory axonal neuropathy", "Sensory neuropathy", "Sepsis", "Septate vagina", "Septic arthritis", "Septo optic dysplasia", "Serositis", "Severe combined immunodeficiency", "Severe cytomegalovirus infection", "Severe demyelination of the white matter", "Severe expressive language delay", "Severe failure to thrive", "Severe global developmental delay", "Severe hearing impairment", "Severe infection", "Severe intrauterine growth retardation", "Severe lactic acidosis", "Severe muscular hypotonia", "Severe photosensitivity", "Severe postnatal growth retardation", "Severe short limb dwarfism", "Severe short stature", "Severe varicella zoster infection", "Severe viral infection", "Severely reduced visual acuity", "Shagreen patch", "Shallow anterior chamber", "Shallow orbits", "Shawl scrotum", "Shield chest", "Shock", "Short 1st metacarpal", "Short attention span", "Short chin", "Short clavicles", "Short columella", "Short digit", "Short face", "Short femur", "Short foot", "Short fourth metatarsal", "Short lingual frenulum", "Short long bone", "Short lower limbs", "Short middle phalanx of finger", "Short nail", "Short nose", "Short palm", "Short palpebral fissure", "Short phalanx of the thumb", "Short philtrum", "Short proximal phalanx of finger", "Short ribs", "Short stepped shuffling gait", "Short sternum", "Short thorax", "Short thumb", "Short tibia", "Short umbilical cord", "Short upper lip", "Shortened pr interval", "Shortened qt interval", "Shortening of all distal phalanges of the fingers", "Shortening of all middle phalanges of the fingers", "Shoulder dislocation", "Shoulder girdle muscle atrophy", "Shoulder girdle muscle weakness", "Shoulder pain", "Shuffling gait", "Shyness", "Sideroblastic anemia", "Simple ear", "Simple febrile seizure", "Simplified gyral pattern", "Single fiber emg abnormality", "Single naris", "Single transverse palmar crease", "Single ventricle", "Sinus bradycardia", "Sinus tachycardia", "Sirenomelia", "Skeletal dysplasia", "Skeletal muscle atrophy", "Skeletal muscle hypertrophy", "Skeletal myopathy", "Skin appendage neoplasm", "Skin dimple", "Skin erosion", "Skin nodule", "Skin picking", "Skin pit", "Skin plaque", "Skin rash", "Skin tags", "Skin ulcer", "Skin vesicle", "Skull asymmetry", "Slanting of the palpebral fissure", "Sleep apnea", "Sleep disturbance", "Sleep wake cycle disturbance", "Slender build", "Slender finger", "Slender long bone", "Slender toe", "Sloping forehead", "Slow decrease in visual acuity", "Slow pupillary light response", "Slow saccadic eye movements", "Slowed slurred speech", "Slowly progressive", "Slurred speech", "Small anterior fontanelle", "Small basal ganglia", "Small cerebral cortex", "Small earlobe", "Small epiphyses", "Small face", "Small for gestational age", "Small hand", "Small intestinal dysmotility", "Small nail", "Small placenta", "Smooth muscle antibody positivity", "Smooth philtrum", "Snoring", "Social and occupational deterioration", "Soft doughy skin", "Soft skin", "Soft tissue sarcoma", "Solitary median maxillary central incisor", "Somatic mutation", "Somatic sensory dysfunction", "Sound sensitivity", "Sparse and thin eyebrow", "Sparse body hair", "Sparse eyebrow", "Sparse eyelashes", "Sparse hair", "Sparse lateral eyebrow", "Sparse or absent eyelashes", "Sparse scalp hair", "Spastic ataxia", "Spastic diplegia", "Spastic dysarthria", "Spastic gait", "Spastic hyperactive bladder", "Spastic paraparesis", "Spastic paraparetic gait", "Spastic paraplegia", "Spastic tetraparesis", "Spastic tetraplegia", "Spasticity", "Specific learning disability", "Speech apraxia", "Speech articulation difficulties", "Spider hemangioma", "Spina bifida", "Spina bifida occulta", "Spinal canal stenosis", "Spinal cord compression", "Spinal cord lesion", "Spinal cord tumor", "Spinal deformities", "Spinal muscular atrophy", "Spinal rigidity", "Spinocerebellar tract degeneration", "Splanchnic vein thrombosis", "Splenomegaly", "Split nail", "Spoken word recognition deficit", "Spondyloepimetaphyseal dysplasia", "Spondyloepiphyseal dysplasia", "Spondylolisthesis", "Spondylolysis", "Spontaneous abortion", "Spontaneous hemolytic crises", "Spontaneous pain sensation", "Spontaneous recurrent epistaxis", "Sporadic", "Spotty hyperpigmentation", "Sprengel anomaly", "Squamous cell carcinoma", "Squamous cell carcinoma of the skin", "Square face", "Squared iliac bones", "St segment elevation", "Stage 5 chronic kidney disease", "Staring gaze", "Status epilepticus", "Status epilepticus with prominent motor symptoms", "Stenosis of the external auditory canal", "Steppage gait", "Stereotypical body rocking", "Stereotypical hand wringing", "Stereotypy", "Steroid resistant nephrotic syndrome", "Stiff skin", "Stillbirth", "Stomach cancer", "Stomatitis", "Stomatocytosis", "Stooped posture", "Streak ovary", "Striae distensae", "Stridor", "Stroke", "Stroke like episode", "Stuttering", "Subacute progressive viral hepatitis", "Subarachnoid hemorrhage", "Subcapsular cataract", "Subcortical band heterotopia", "Subcortical cerebral atrophy", "Subcortical heterotopia", "Subcutaneous hemorrhage", "Subcutaneous nodule", "Subdural hemorrhage", "Subependymal cysts", "Subglottic stenosis", "Submucous cleft of soft and hard palate", "Submucous cleft soft palate", "Subretinal fluid", "Subsarcolemmal accumulations of abnormally shaped mitochondria", "Substantia nigra gliosis", "Subvalvular aortic stenosis", "Sudden death", "Sudden episodic apnea", "Sudden loss of visual acuity", "Suicidal ideation", "Sunken cheeks", "Supernumerary bones of the axial skeleton", "Supernumerary nipple", "Supernumerary spleens", "Supernumerary tooth", "Supranuclear gaze palsy", "Supranuclear ophthalmoplegia", "Supravalvular aortic stenosis", "Supraventricular arrhythmia", "Supraventricular tachycardia", "Swan neck like deformities of the fingers", "Symphalangism affecting the phalanges of the hand", "Symphalangism of middle phalanx of finger", "Symptomatic seizures", "Syncope", "Syndactyly", "Synostosis involving bones of the hand", "Synostosis involving bones of the lower limbs", "Synostosis involving bones of the upper limbs", "Synostosis involving digits", "Synostosis of carpal bones", "Synostosis of carpals tarsals", "Synostosis of joints", "Synostosis of metacarpals metatarsals", "Synovitis", "Syringomyelia", "Systemic lupus erythematosus", "T cell lymphoma", "T lymphocytopenia", "Tachycardia", "Tachypnea", "Talipes calcaneovalgus", "Talipes equinovalgus", "Talipes equinovarus", "Talipes valgus", "Tall chin", "Tall stature", "Tapered distal phalanges of finger", "Tapered finger", "Tarsal synostosis", "Telangiectasia", "Telangiectasia of the skin", "Telecanthus", "Temperature instability", "Temporal cortical atrophy", "Temporal optic disc pallor", "Temporal pattern", "Tendon xanthomatosis", "Tented upper lip vermilion", "Teratoma", "Testicular adrenal rest tumor", "Testicular atrophy", "Testicular dysgenesis", "Tetany", "Tetralogy of fallot", "Tetraparesis", "Tetraplegia", "Tetraplegia tetraparesis", "Thenar muscle atrophy", "Thick cerebral cortex", "Thick corpus callosum", "Thick eyebrow", "Thick hair", "Thick lower lip vermilion", "Thick nasal alae", "Thick upper lip vermilion", "Thick vermilion border", "Thickened calvaria", "Thickened cortex of long bones", "Thickened ears", "Thickened helices", "Thickened nuchal skin fold", "Thickened ribs", "Thickened skin", "Thin bony cortex", "Thin clavicles", "Thin eyebrow", "Thin lower lip vermilion", "Thin nail", "Thin ribs", "Thin skin", "Thin upper lip vermilion", "Thin vermilion border", "Third degree atrioventricular block", "Thoracic aortic aneurysm", "Thoracic dysplasia", "Thoracic hypoplasia", "Thoracic kyphoscoliosis", "Thoracic kyphosis", "Thoracic scoliosis", "Thoracolumbar kyphoscoliosis", "Thoracolumbar kyphosis", "Thoracolumbar scoliosis", "Thrombocytosis", "Thromboembolism", "Thyroid adenoma", "Thyroid carcinoma", "Thyroiditis", "Tibial bowing", "Tibial torsion", "Tics", "Tiger tail banding", "Tinnitus", "Tip toe gait", "Tissue ischemia", "Titubation", "Toe clinodactyly", "Toe syndactyly", "Toe walking", "Toenail dysplasia", "Tongue atrophy", "Tongue fasciculations", "Tongue nodules", "Tongue thrusting", "Tonic seizure", "Tooth malposition", "Torsade de pointes", "Torsion dystonia", "Total anomalous pulmonary venous return", "Toxemia of pregnancy", "Tracheal stenosis", "Tracheobronchomalacia", "Tracheoesophageal fistula", "Tracheomalacia", "Tractional retinal detachment", "Transient global amnesia", "Transient ischemic attack", "Transient neutropenia", "Transposition of the great arteries", "Tremor", "Tremor by anatomical site", "Triangular face", "Triangular mouth", "Triangular shaped phalanges of the hand", "Triceps weakness", "Trichorrhexis nodosa", "Tricuspid atresia", "Tricuspid stenosis", "Tricuspid valve prolapse", "Trigonocephaly", "Triphalangeal thumb", "Trismus", "Tritanomaly", "Trophic changes related to pain", "True hermaphroditism", "Truncal ataxia", "Truncal obesity", "Truncal titubation", "Truncus arteriosus", "Tube feeding", "Tubulointerstitial nephritis", "Turricephaly", "Type 1 fibers relatively smaller than type 2 fibers", "Type 1 muscle fiber atrophy", "Type 2 muscle fiber atrophy", "Type 2 muscle fiber predominance", "Type i diabetes mellitus", "Type i transferrin isoform profile", "Type ii diabetes mellitus", "Type ii lissencephaly", "Type ii transferrin isoform profile", "Typical absence seizure", "U shaped upper lip vermilion", "Ulcerative colitis", "Ulnar bowing", "Ulnar claw", "Ulnar deviation of finger", "Ulnar deviation of the 2nd finger", "Ulnar deviation of the hand", "Ulnar deviation of the hand or of fingers of the hand", "Ulnar deviation of the wrist", "Uncombable hair", "Unconjugated hyperbilirubinemia", "Underdeveloped nasal alae", "Underdeveloped supraorbital ridges", "Underdeveloped tragus", "Undetectable electroretinogram", "Undetectable light and dark adapted electroretinogram", "Undetectable visual evoked potentials", "Unexplained fevers", "Unilateral ptosis", "Unilateral renal agenesis", "Unsteady gait", "Unusual fungal infection", "Unusual infection", "Unusual infection by anatomical site", "Unusual skin infection", "Upgaze palsy", "Uplifted earlobe", "Upper airway obstruction", "Upper extremity joint dislocation", "Upper eyelid coloboma", "Upper limb amyotrophy", "Upper limb asymmetry", "Upper limb hypertonia", "Upper limb muscle weakness", "Upper limb pain", "Upper limb postural tremor", "Upper limb spasticity", "Upper limb undergrowth", "Upper motor neuron dysfunction", "Upslanted palpebral fissure", "Ureteral duplication", "Ureteral obstruction", "Ureteral stenosis", "Ureterocele", "Ureteropelvic junction obstruction", "Urethral atresia", "Urethral obstruction", "Urethral stenosis", "Urethral stricture", "Urethral valve", "Urethrovaginal fistula", "Uric acid nephrolithiasis", "Urinary bladder sphincter dysfunction", "Urinary glycosaminoglycan excretion", "Urinary incontinence", "Urinary retention", "Urinary tract neoplasm", "Urinary urgency", "Urogenital fistula", "Urogenital sinus anomaly", "Urticaria", "Uterine prolapse", "Uterus didelphys", "Uveal melanoma", "Uveitis", "Vacuolated lymphocytes", "Vaginal atresia", "Vaginal fistula", "Vaginal neoplasm", "Variable expressivity", "Varicose veins", "Vascular calcification", "Vascular dilatation", "Vascular neoplasm", "Vascular skin abnormality", "Vascular tortuosity", "Vasculitis", "Vegetative state", "Vein of galen aneurysmal malformation", "Velopharyngeal insufficiency", "Venous insufficiency", "Venous malformation", "Venous thrombosis", "Ventilator dependence with inability to wean", "Ventricular arrhythmia", "Ventricular escape rhythm", "Ventricular fibrillation", "Ventricular hypertrophy", "Ventricular preexcitation", "Ventricular septal hypertrophy", "Ventricular tachycardia", "Ventriculomegaly", "Verrucae", "Vertebral arch anomaly", "Vertebral clefting", "Vertebral compression fracture", "Vertebral fusion", "Vertebral hypoplasia", "Vertebral segmentation defect", "Vertebral wedging", "Vertical nystagmus", "Vertical supranuclear gaze palsy", "Vertigo", "Very long chain fatty acid accumulation", "Vestibular dysfunction", "Viral encephalitis", "Viral hepatitis", "Viral infection induced rhabdomyolysis", "Visceral angiomatosis", "Visual acuity test abnormality", "Visual agnosia", "Visual field defect", "Visual fixation instability", "Visual hallucinations", "Visual impairment", "Visual loss", "Vitamin b12 deficiency", "Vitiligo", "Vitreoretinopathy", "Vitreous floaters", "Vitreous hemorrhage", "Vitritis", "Vocal cord paralysis", "Vocal cord paresis", "Volvulus", "Vomiting", "Waddling gait", "Weak cry", "Weak voice", "Weakness due to upper motor neuron dysfunction", "Weakness of facial musculature", "Weakness of long finger extensor muscles", "Weakness of muscles of respiration", "Weakness of the intrinsic hand muscles", "Webbed neck", "Weight loss", "Wheezing", "White forelock", "White hair", "Wide anterior fontanel", "Wide cranial sutures", "Wide intermamillary distance", "Wide mouth", "Wide nasal bridge", "Wide nasal ridge", "Wide nose", "Wide pubic symphysis", "Widely patent fontanelles and sutures", "Widely spaced incisors", "Widely spaced teeth", "Widened cerebral subarachnoid space", "Widened subarachnoid space", "Widow s peak", "Woolly hair", "Wormian bones", "Wrist flexion contracture", "Writer s cramp", "X linked dominant inheritance", "X linked recessive inheritance", "Xanthelasma", "Xanthomatosis", "Xerostomia", "Y shaped metacarpals", "Yellow white lesions of the retina", "Young adult onset", "Zollinger ellison syndrome", "Zonular cataract"], "available_proteins": ["AAAS", "AARS", "AARS2", "AASS", "ABCB1", "ABCB7", "ABCC1", "ABCD3", "ABHD12", "ACACA", "ACAD9", "ACADM", "ACADVL", "ACAT1", "ACAT2", "ACBD5", "ACO2", "ACOX1", "ACP2", "ACSF3", "ACSL4", "ACTL6A", "ACTN1", "ACTN4", "ADAR", "ADD1", "ADD3", "ADH5", "ADNP", "ADPRHL2", "ADSL", "AFG3L2", "AGK", "AGL", "AGPS", "AHCY", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AKT2", "ALDH18A1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDOA", "ALG1", "ALG11", "ALG12", "ANAPC1", "ANAPC2", "ANKFY1", "ANKLE2", "ANKRD17", "ANO10", "ANO6", "ANXA11", "AP1B1", "AP1S2", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "APOL2", "APP", "APRT", "ARCN1", "ARHGDIA", "ARHGEF1", "ARHGEF2", "ARID1A", "ARL2", "ARL3", "ARL6IP1", "ARL6IP6", "ASAH1", "ASNA1", "ASNS", "ASPH", "ATAD1", "ATAD3A", "ATG7", "ATIC", "ATP1A1", "ATP2A2", "ATP5A1", "ATP6", "ATP6AP1", "ATP6AP2", "ATP6V0A2", "ATP6V1A", "ATP6V1B2", "ATP6V1E1", "ATP7B", "ATRIP", "ATXN10", "AURKA", "B3GALT6", "B4GAT1", "BANF1", "BAZ1B", "BCAP31", "BCS1L", "BICD2", "BLVRA", "BMS1", "BRAT1", "BUB1B", "BUB3", "BUD23", "C19orf70", "C1QBP", "C21orf59", "CAD", "CALD1", "CALM3", "CALR", "CAMK2G", "CAPN1", "CARS", "CARS2", "CASK", "CAST", "CCDC22", "CCDC47", "CCT5", "CD2AP", "CD320", "CDC40", "CDC42", "CDC73", "CDH2", "CDK4", "CDK5", "CDK6", "CDKN2A", "CELF2", "CEP290", "CEP55", "CERS1", "CFL2", "CHAMP1", "CHD1", "CHD4", "CHMP1A", "CHMP2B", "CHMP4B", "CHORDC1", "CHST14", "CISD2", "CLASP1", "CLCC1", "CLCN7", "CLN5", "CLPB", "CLPP", "CLPX", "CLTC", "CNNM4", "CNOT1", "CNOT2", "CNP", "COA3", "COA7", "COASY", "COG4", "COLEC12", "COLGALT1", "COMT", "COPA", "COPB1", "COPB2", "COQ8A", "COQ9", "COX2", "COX4I1", "COX5A", "CPNE1", "CPOX", "CPSF1", "CPT1A", "CPT2", "CRKL", "CRTAP", "CSNK2B", "CSTB", "CTBP1", "CTCF", "CTNNA1", "CTNNB1", "CTNND1", "CTPS1", "CTSA", "CTSB", "CTSC", "CUL3", "CUL4B", "CWC27", "CWF19L1", "CXorf56", "CYB5R3", "CYC1", "CYFIP2", "DAG1", "DARS", "DARS2", "DAXX", "DBT", "DCPS", "DCTN1", "DCTN4", "DCXR", "DDB1", "DDOST", "DDRGK1", "DDX3X", "DDX41", "DDX6", "DEGS1", "DGKE", "DHCR24", "DHCR7", "DHFR", "DHPS", "DHX16", "DHX30", "DHX37", "DHX38", "DIABLO", "DIAPH1", "DIAPH2", "DIAPH3", "DKC1", "DLAT", "DLD", "DLG3", "DLST", "DNAAF5", "DNAJC13", "DNAJC19", "DNAJC3", "DNM1L", "DNM2", "DNMT1", "DOCK7", "DPAGT1", "DPM1", "DPP9", "DPYSL5", "DSC3", "DSG2", "DSP", "DST", "DYM", "DYNC1H1", "DYNC1I2", "EARS2", "ECE1", "ECHS1", "EDC3", "EEF1A2", "EEF2", "EFL1", "EFTUD2", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B5", "EIF3F", "EIF4A3", "EIF4G1", "EIF4H", "EIF5A", "ELAC2", "ELMO2", "ELP1", "ELP2", "EMC1", "EMD", "EMG1", "EPB41", "EPHX2", "EPRS", "EPS15L1", "ERAL1", "ERAP1", "ERCC2", "ERCC3", "ERLIN1", "ERLIN2", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXOC2", "EXOC6B", "EXOC7", "EXOC8", "EXOSC2", "EXOSC3", "EXOSC9", "EZR", "FAH", "FAM50A", "FANCD2", "FANCI", "FAR1", "FARS2", "FARSA", "FARSB", "FASN", "FASTKD2", "FDFT1", "FDPS", "FDXR", "FECH", "FH", "FHL1", "FIP1L1", "FKBP10", "FKBP14", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FMR1", "FOXRED1", "FSCN1", "FTL", "FTO", "FUCA1", "FUS", "FXR1", "G6PD", "GAA", "GAL", "GALK1", "GALNT2", "GANAB", "GAPVD1", "GARS", "GATAD2B", "GBA", "GBE1", "GCDH", "GCLC", "GDAP1", "GDI1", "GEMIN4", "GEMIN5", "GFM1", "GFPT1", "GGCX", "GIGYF2", "GLA", "GLB1", "GLDC", "GLMN", "GLS", "GLT8D1", "GLUD1", "GM2A", "GMPPB", "GNAI2", "GNAI3", "GNPAT", "GNS", "GOT2", "GPAA1", "GPD2", "GPHN", "GPI", "GPKOW", "GPT2", "GRHPR", "GSR", "GSS", "GSTM3", "GTF2I", "GTPBP3", "GUF1", "GYG1", "GYS1", "H2AFY", "HADH", "HADHA", "HADHB", "HCCS", "HCFC1", "HELLS", "HEXA", "HEXB", "HIBCH", "HIKESHI", "HIST1H1E", "HK1", "HLA-A", "HLA-B", "HLA-C", "HMBS", "HMGA1", "HMGB3", "HMGCL", "HMMR", "HMOX1", "HNRNPA1", "HNRNPA2B1", "HNRNPDL", "HNRNPH2", "HNRNPK", "HNRNPU", "HPRT1", "HPS6", "HS2ST1", "HSD17B10", "HSD17B4", "HSPA9", "HSPB1", "HSPD1", "HTRA2", "HUWE1", 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"MTCH1", "MTHFD1", "MTMR14", "MTMR2", "MTOR", "MTPAP", "MTR", "MTX2", "MUT", "MVK", "MYH9", "MYO6", "NAA15", "NADK2", "NAGA", "NAGLU", "NANS", "NARS", "NAXE", "NCAPD2", "NCAPD3", "NCAPG2", "NCAPH", "NCDN", "NCSTN", "ND1", "NDUFA11", "NDUFA13", "NDUFA4", "NDUFA8", "NDUFA9", "NDUFAF2", "NDUFAF3", "NDUFAF4", "NDUFB10", "NDUFB3", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS6", "NDUFS7", "NDUFS8", "NDUFV1", "NDUFV2", "NEFL", "NEK9", "NEMF", "NFU1", "NHP2", "NNT", "NONO", "NOP56", "NPC1", "NPC2", "NPM1", "NSD2", "NSDHL", "NSF", "NSMCE2", "NSUN2", "NT5C2", "NTHL1", "NUBPL", "NUMA1", "NUP107", "NUP133", "NUP155", "NUP160", "NUP188", "NUP205", "NUP214", "NUP37", "NUP62", "NUP85", "NUP88", "NUP93", "NXN", "OAT", "OCLN", "OCRL", "OGDH", "OGT", "OPA1", "OPA3", "OSGEP", "OXCT1", "P3H1", "P4HB", "PABPN1", "PAFAH1B1", "PALLD", "PARK7", "PARN", "PBRM1", "PC", "PCBD1", "PCCA", "PCCB", "PCK2", "PCNA", "PDCD6", "PDE6D", "PDHA1", "PDHB", "PDK3", "PDXK", "PEPD", "PEX14", "PEX16", "PEX19", "PEX5", "PFKM", "PFN1", "PGK1", "PGM1", "PGM3", "PHB", "PHF6", "PHGDH", "PHIP", "PHKA1", "PIBF1", "PICALM", "PIGK", "PIGS", "PIGT", "PIGU", "PISD", "PITRM1", "PKN1", "PLAA", "PLD3", "PLEC", "PLOD1", "PLOD2", "PLPBP", "PLS3", "PMPCA", "PMPCB", "PMVK", "PNKP", "PNP", "PNPLA6", "PNPT1", "PODXL", "POFUT1", "POGZ", "POLA1", "POLD1", "POLE", "POLR1A", "POLR1B", "POLR1C", "POLR2A", "POLR3A", "PON2", "POP1", "POR", "PPA2", "PPIB", "PPIL1", "PPOX", "PPP1CB", "PPP1R12A", "PPP2R1A", "PPP2R1B", "PPP2R5D", "PPP3CA", "PPT1", "PRCC", "PREPL", "PRKACA", "PRKAR1A", "PRKCSH", "PRKDC", "PRKRA", "PRPF31", "PRPF4", "PRPF6", "PRPF8", "PSAP", "PSAT1", "PSMB4", "PSMC3", "PSMD12", "PTCD3", "PTDSS1", "PTPN1", "PTPN11", "PTPRF", "PTRH2", "PUF60", "PUM1", "PURA", "PUS7", "PXMP2", "PYCR1", "PYCR2", "PYGL", "QARS", "QRSL1", "RAB18", "RAB3GAP1", "RAB3GAP2", "RAB7A", "RAC1", "RAD21", "RAD50", "RALA", "RANBP2", "RAPGEF2", "RARS", "RARS2", "RBM10", "RBM12", "RBM28", "RBM8A", "RBMX", "RDH11", "RDX", "RFC1", "RFC2", "RFT1", "RINT1", 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"title": "Average number of proteins per term", + "value": 15.525139664804469 +} \ No newline at end of file diff --git a/msigdb_kegg/paths.json b/msigdb_kegg/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..12f036dbeb7aaa697f478cfeee6c90ca859f60fc --- /dev/null +++ b/msigdb_kegg/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/msigdb_kegg/fragment/C220/C220_val_log2fc"} \ No newline at end of file diff --git a/msigdb_kegg/result.tsv b/msigdb_kegg/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..b44e5ca361538186720a74611ae6179229de8887 --- /dev/null +++ b/msigdb_kegg/result.tsv @@ -0,0 +1,57 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Lysosome 0.6335788440707509 3.942605918543873 8.060103506180027e-05 0.0143245795382219 0.0097064434350487 49 O75503,P17050,Q8NCC3,P54802,P13473,P07858,P50897,P16278,O43681,P04062,Q9NZJ7,P07602,P17900,P11279,O14773,Q9Y487,Q9UMR5,P06865,P11117,P06280,P10253,Q13510,Q93050,P10619,O15118,Q14108,Q15904 27 +Parkinsons disease 0.5918787561661857 3.799309908687286 0.0001450995566791 0.025640264419847 0.0097064434350487 54 P13073,P14406,P00403,Q9Y277,O96000,P45880,Q9UDW1,P05141,O95139,P21796,P00846,O43676,O75438,O14949,P24539,P12236,P21912,P03886,P12235,P22695 20 +Oxidative phosphorylation 0.5614783567140905 3.718840712617389 0.0002001392041346 0.0351942594176441 0.0097064434350487 58 P13073,P14406,Q86Y39,P00403,O96000,Q9UDW1,O75964,O95139,P00846,Q9Y6M9,O43676,O75438,O14949,P24539,Q9Y487,P21912,P03886,Q93050,Q15904,P22695 20 +Huntingtons disease 0.5026200539631211 3.374930283049886 0.0007383439279866 0.1238451009005063 0.0264327126219225 73 P13073,P14406,P00403,Q9Y277,O96000,P45880,Q9UDW1,P05141,O95139,P21796,P00846,Q9Y6M9,O43676,O75438,O14949,P24539,P12236,P21912,P12235,P22695 20 +Sphingolipid metabolism 0.7986244272807433 3.196318260334856 0.0013919348411253 0.2206771694501056 0.0348419451079595 14 O15269,O43681,P04062,O95470,O15121,Q06136,P06280,Q9NRA0,Q16739,Q13510,P16278 11 +Cardiac muscle contraction 0.6759068605189505 3.048515644078952 0.0022997493844083 0.3377613030457591 0.0437765263269813 19 P13073,P14406,P00403,P05023,O14949,Q9UDW1,P22695 7 +Snare interactions in vesicular transport 0.7334353579290528 2.833104242883719 0.0046098350324135 0.5626704560595753 0.0581235139766939 14 Q12846,Q9P2W9,O15400,Q86Y82,Q13190,Q12981,O60499,O15498,O95249,Q9UNK0 10 +Alzheimers disease 0.4737955499890065 2.7579959517215107 0.0058156918137128 0.647973110540643 0.0650630521659129 57 O95139,P24539,O14949,P13073,P00846,P14406,Q9Y6M9,O43676,Q92542,P16615,O75438,P49327,P00403,P21912,P22695,O96000,Q9UDW1 17 +Biosynthesis of unsaturated fatty acids 0.80228555573984 2.7132492379065405 0.0066626973593437 0.6977840968416642 0.0701542839601491 10 O00767,Q6Y1H2,Q53GQ0,O15254,Q15067,O95864,P40939,Q9NZ01 8 +Calcium signaling pathway 0.5793584229213454 2.275293465391127 0.0228883311847882 0.9841506392370336 0.1528449517213093 18 P20020,P21796,P16615,P12236,P12235,Q9Y277,P45880,P05141 8 +Steroid biosynthesis 0.7162894777555004 2.27252491149763 0.023054825119974 0.984626795139436 0.1528449517213093 10 P35610,P37268,Q15800,Q14534,Q16850,Q15392 6 +N glycan biosynthesis 0.5509736234222482 2.0765584329601565 0.0378423327292696 0.9989975150539064 0.1941948283663533 18 P46977,Q96AA3,Q9H3H5,Q9BV10,Q9BT22,Q86YN1 6 +Protein export 0.5736445152227438 1.9484558159206735 0.0513604467434509 0.999920362081996 0.2476028254320721 15 Q9Y5M8,P60059,Q15005,P67812,Q99442,Q9UHB9,Q15070 7 +Abc transporters 0.7878073425395749 1.9309641692697916 0.053487483608904 0.9999467133184344 0.2476028254320721 5 P08183,O75027,Q03518,P33527 4 +O glycan biosynthesis 0.8283444266221719 1.8217889929443931 0.0684870085240878 0.9999969463728808 0.3064793631452931 4 O43505,Q8N4A0 2 +Allograft rejection 0.8168350168350142 1.7724159852388477 0.0763255302151371 0.9999993271933854 0.3105061342843078 4 P49327,P10321,P04439 3 +Autoimmune thyroid disease 0.8168350168350142 1.7724159852388477 0.0763255302151371 0.9999993271933854 0.3105061342843078 4 P49327,P10321,P04439 3 +Graft versus host disease 0.8168350168350142 1.7724159852388477 0.0763255302151371 0.9999993271933854 0.3105061342843078 4 P49327,P10321,P04439 3 +Ecm receptor interaction 0.7429205068840765 1.7266455063515709 0.0842313479456595 0.999999855571346 0.327769810484197 5 Q08722 1 +Type i diabetes mellitus 0.7210965856345639 1.6260011117701636 0.1039494188534289 0.999999997065581 0.3721389194952755 5 P49327,P10321,P04439 3 +Steroid hormone biosynthesis 0.91083445491252 1.5869040666348793 0.1125343737626396 0.9999999994762478 0.3813578434258443 2 P21964 1 +Glycosylphosphatidylinositol gpi anchor biosynthesis 0.6999536434921376 1.5277764892611043 0.1265680415003118 0.9999999999698002 0.41954961904733 5 Q9H490,O43292 2 +Vibrio cholerae infection 0.4348121601747569 1.4061502185874442 0.1596795228686378 0.99999999999997 0.4928040447152789 20 Q93050,P24390,Q9Y487,Q15904,P61421 5 +Other glycan degradation 0.6158907820680696 1.3818403580954135 0.1670207241349783 0.9999999999999938 0.5018896753494914 7 Q9BTY2,P16278,P04062 3 +Glycerophospholipid metabolism 0.4481597014281898 1.3208687279739737 0.186545138504508 1.0 0.521743434254796 18 P48651,Q8NF37,Q92604,Q8NCC3,Q99943,O14735,O95674,Q9UG56,Q96N66 9 +Folate biosynthesis 0.8475846172207063 1.2922612253658043 0.1962666951173792 1.0 0.5379105413293533 3 P35270 1 +Alpha linolenic acid metabolism 0.8455065634466448 1.2839713670826471 0.1991519741474514 1.0 0.5379105413293533 3 Q15067,O95864 2 +Renin angiotensin system 0.6983164983165084 1.255178805637085 0.2094138576482604 1.0 0.5379105413293533 4 Q9BYT8,P10619,Q9UIQ6 3 +Porphyrin and chlorophyll metabolism 0.4988793538396441 1.2523417112681263 0.2104453760212075 1.0 0.5379105413293533 12 P30519,P09601,P53701 3 +Rig i like receptor signaling pathway 0.5685376788889531 1.1401681797492664 0.2542162415384248 1.0 0.5987461478339217 7 Q86UT6 1 +Glycosphingolipid biosynthesis ganglio series 0.6673718350556387 1.1189553971483046 0.2631591677826901 1.0 0.6117596238065134 4 O00400,P16278 2 +Proximal tubule bicarbonate reclamation 0.5502488859023218 1.0921606088593223 0.2747625131261599 1.0 0.6273479117931646 8 P05023,Q9UBX3,P00367,Q16822 4 +Glycosaminoglycan biosynthesis chondroitin sulfate 0.784993270524909 1.0539371535259028 0.2919116913179564 1.0 0.6273479117931646 2 Q8NCH0 1 +Glycosaminoglycan biosynthesis heparan sulfate 0.7849932705249064 1.0539371535258926 0.2919116913179611 1.0 0.6273479117931646 2 Q7LGA3 1 +Phosphatidylinositol signaling system 0.4713928972369773 1.0296672708526258 0.3031662245623372 1.0 0.6273479117931646 11 O95674,Q10713,Q9UBF8 3 +Nicotinate and nicotinamide metabolism 0.6461776063485306 1.0259564474055034 0.3049121135531023 1.0 0.6273479117931646 4 P43490 1 +Glycosaminoglycan degradation 0.5863905610160655 0.9934669348219428 0.3204824563564092 1.0 0.6303995570087612 5 P54802,P16278,P06865 3 +Glycosphingolipid biosynthesis globo series 0.6234096111416009 0.9266791275337964 0.3540931577536255 1.0 0.6602362003947808 4 P06280,P17050 2 +Amyotrophic lateral sclerosis als 0.4402838837145804 0.8382822483509603 0.4018722033177146 1.0 0.7043757391646367 11 P07197,O96008,Q16539,Q9BUN8 4 +Cell adhesion molecules cams 0.4746980116249395 0.7990529416255089 0.4242597146233691 1.0 0.7043757391646367 9 P01889,P10586,Q16625,P10321,P04439 5 +Butanoate metabolism 0.3791491817557291 0.792413810501609 0.4281194293312911 1.0 0.7043757391646367 18 Q9H9P8,Q16836,P35610,Q9BWD1,P40939,P51649,P51648 7 +Ppar signaling pathway 0.3857086346592234 0.7177759551114145 0.4728954414368425 1.0 0.71029330106598 16 P50416,P22307,O00767,P23786,O15254,Q15067,O95864,Q16822 8 +Antigen processing and presentation 0.3675304655170416 0.7038104435713267 0.4815508290226944 1.0 0.71029330106598 18 P01889,P27824,Q99538,P07858,P10321,P04439,Q03518 7 +Tryptophan metabolism 0.3963248467832702 0.6921523664943804 0.4888416486650375 1.0 0.71029330106598 14 P40939,P51648,P35610,Q9BWD1 4 +Peroxisome 0.324939744132518 0.6692254675025655 0.5033516628182753 1.0 0.71029330106598 34 P48735,P22307,Q9Y5Y5,Q9NR77,Q9BTZ2,O15254,Q15067,O43808,O75192,Q9BY49,O75381,O00116,P28288,P40855,P50542 15 +Hypertrophic cardiomyopathy hcm 0.4318812661943201 0.6689964253526607 0.503497758237442 1.0 0.71029330106598 10 P50402,P02545,P16615,P54646 4 +Lysine degradation 0.3432383836994242 0.5825808061173455 0.5601755295221951 1.0 0.7319081736092914 19 P40939,P51648,P35610,Q9BWD1 4 +Fatty acid metabolism 0.3226149265232658 0.5426985843283589 0.5873373491071305 1.0 0.7535110837908673 26 P35610,P23786,Q9BWD1,O15254,Q15067,P40939,P51648 7 +Metabolism of xenobiotics by cytochrome p450 0.4440341913243322 0.5137061897301787 0.6074574237519896 1.0 0.7657385834620151 7 P07099,Q99735 2 +Epithelial cell signaling in helicobacter pylori infection 0.3166958965795919 0.4446354693350303 0.6565832105309004 1.0 0.788684036988651 21 Q93050,Q9Y487,Q16539 3 +Primary bile acid biosynthesis 0.6137281292059279 0.4059809207603276 0.6847566191580585 1.0 0.7992845217011723 2 P22307 1 +Dilated cardiomyopathy 0.399497692098808 0.4012579193591078 0.6882302418013162 1.0 0.7992845217011723 9 P16615 1 +Nitrogen metabolism 0.6065297879501713 0.3959825763683196 0.6921178819200096 1.0 0.7992845217011723 3 P08243,P00367 2 +Ether lipid metabolism 0.4318327952711061 0.3153415530654433 0.7525023383850802 1.0 0.8299970741006231 5 Q8NF37 1 +Hedgehog signaling pathway 0.4145356662180325 0.0336961454683477 0.9731194526994248 1.0 1.0 2 P48729 1 +Basal transcription factors 0.3299879484855621 0.0143540326594201 0.9885475322315488 1.0 1.0 5 P35269 1 diff --git a/msigdb_kegg/selections.json b/msigdb_kegg/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..70ef4ea837f3b95d2cb76fbc1c52762e8bd7c96b --- /dev/null +++ b/msigdb_kegg/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["Abc transporters", "Acute myeloid leukemia", "Adherens junction", "Adipocytokine signaling pathway", "Alanine aspartate and glutamate metabolism", "Aldosterone regulated sodium reabsorption", "Allograft rejection", "Alpha linolenic acid metabolism", "Alzheimers disease", "Amino sugar and nucleotide sugar metabolism", "Aminoacyl trna biosynthesis", "Amyotrophic lateral sclerosis als", "Antigen processing and presentation", "Apoptosis", "Arachidonic acid metabolism", "Arginine and proline metabolism", "Arrhythmogenic right ventricular cardiomyopathy arvc", "Ascorbate and aldarate metabolism", "Autoimmune thyroid disease", "Axon guidance", "B cell receptor signaling pathway", "Basal cell carcinoma", "Basal transcription factors", "Base excision repair", "Beta alanine metabolism", "Biosynthesis of unsaturated fatty acids", "Bladder cancer", "Butanoate metabolism", "Calcium signaling pathway", "Cardiac muscle contraction", "Cell adhesion molecules cams", "Cell cycle", "Chemokine signaling pathway", "Chronic myeloid leukemia", "Citrate cycle tca cycle", "Colorectal cancer", "Cysteine and methionine metabolism", "Cytokine cytokine receptor interaction", "Cytosolic dna sensing pathway", "Dilated cardiomyopathy", "Dna replication", "Dorso ventral axis formation", "Drug metabolism cytochrome p450", "Drug metabolism other enzymes", "Ecm receptor interaction", "Endocytosis", "Endometrial cancer", "Epithelial cell signaling in helicobacter pylori infection", "Erbb signaling pathway", "Ether lipid metabolism", "Fatty acid metabolism", "Fc epsilon ri signaling pathway", "Fc gamma r mediated phagocytosis", "Focal adhesion", "Folate biosynthesis", "Fructose and mannose metabolism", "Galactose metabolism", "Gap junction", "Glioma", "Glutathione metabolism", "Glycerolipid metabolism", "Glycerophospholipid metabolism", "Glycine serine and threonine metabolism", "Glycolysis gluconeogenesis", "Glycosaminoglycan biosynthesis chondroitin sulfate", "Glycosaminoglycan biosynthesis heparan sulfate", "Glycosaminoglycan biosynthesis keratan sulfate", "Glycosaminoglycan degradation", "Glycosphingolipid biosynthesis ganglio series", "Glycosphingolipid biosynthesis globo series", "Glycosphingolipid biosynthesis lacto and neolacto series", "Glycosylphosphatidylinositol gpi anchor biosynthesis", "Glyoxylate and dicarboxylate metabolism", "Gnrh signaling pathway", "Graft versus host disease", "Hedgehog signaling pathway", "Hematopoietic cell lineage", "Histidine metabolism", "Homologous recombination", "Huntingtons disease", "Hypertrophic cardiomyopathy hcm", "Inositol phosphate metabolism", "Insulin signaling pathway", "Jak stat signaling pathway", "Leishmania infection", "Leukocyte transendothelial migration", "Limonene and pinene degradation", "Long term depression", "Long term potentiation", "Lysine degradation", "Lysosome", "Mapk signaling pathway", "Melanogenesis", "Melanoma", "Metabolism of xenobiotics by cytochrome p450", "Mismatch repair", "Mtor signaling pathway", "N glycan biosynthesis", "Natural killer cell mediated cytotoxicity", "Neuroactive ligand receptor interaction", "Neurotrophin signaling pathway", "Nicotinate and nicotinamide metabolism", "Nitrogen metabolism", "Nod like receptor signaling pathway", "Non homologous end joining", "Non small cell lung cancer", "Notch signaling pathway", "Nucleotide excision repair", "O glycan biosynthesis", "Olfactory transduction", "One carbon pool by folate", "Oocyte meiosis", "Other glycan degradation", "Oxidative phosphorylation", "P53 signaling pathway", "Pancreatic cancer", "Pantothenate and coa biosynthesis", "Parkinsons disease", "Pathogenic escherichia coli infection", "Pathways in cancer", "Pentose and glucuronate interconversions", "Pentose phosphate pathway", "Peroxisome", "Phenylalanine metabolism", "Phosphatidylinositol signaling system", "Porphyrin and chlorophyll metabolism", "Ppar signaling pathway", "Primary bile acid biosynthesis", "Primary immunodeficiency", "Prion diseases", "Progesterone mediated oocyte maturation", "Propanoate metabolism", "Prostate cancer", "Proteasome", "Protein export", "Proximal tubule bicarbonate reclamation", "Purine metabolism", "Pyrimidine metabolism", "Pyruvate metabolism", "Regulation of actin cytoskeleton", "Regulation of autophagy", "Renal cell carcinoma", "Renin angiotensin system", "Retinol metabolism", "Riboflavin metabolism", "Ribosome", "Rig i like receptor signaling pathway", "Rna degradation", "Rna polymerase", "Selenoamino acid metabolism", "Small cell lung cancer", "Snare interactions in vesicular transport", "Sphingolipid metabolism", "Spliceosome", "Starch and sucrose metabolism", "Steroid biosynthesis", "Steroid hormone biosynthesis", "Sulfur metabolism", "Systemic lupus erythematosus", "T cell receptor signaling pathway", "Taste transduction", "Terpenoid backbone biosynthesis", "Tgf beta signaling pathway", "Thyroid cancer", "Tight junction", "Toll like receptor signaling pathway", "Tryptophan metabolism", "Type i diabetes mellitus", "Type ii diabetes mellitus", "Tyrosine metabolism", "Ubiquitin mediated proteolysis", "Valine leucine and isoleucine biosynthesis", "Valine leucine and isoleucine degradation", "Vascular smooth muscle contraction", "Vasopressin regulated water reabsorption", "Vegf signaling pathway", "Vibrio cholerae infection", "Viral myocarditis", "Wnt signaling pathway"], "available_proteins": ["AARS", "AARS2", "AASDHPPT", "AASS", "ABCB1", "ABCB7", "ABCC1", "ABCD3", "ACAA2", "ACACA", "ACACB", "ACADM", "ACADVL", "ACAT1", "ACAT2", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT7", "ACOX1", "ACOX3", "ACP1", "ACP2", "ACP6", "ACSL1", "ACSL3", "ACSL4", "ACTN1", "ACTN4", "ADAR", "ADH5", "ADI1", "ADSL", "ADSS", "AFDN", "AGK", "AGL", "AGPAT1", "AGPS", "AHCY", "AHCYL1", "AIFM1", "AK1", "AK2", "AKR1A1", "AKR1B1", "AKT2", "ALDH18A1", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALG1", "ALG11", "ALG12", "ALYREF", "ANAPC1", "ANAPC2", "ANAPC5", "ANAPC7", "AP1B1", "AP1G1", "AP1M1", "AP1S2", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "AP3S1", "APEX1", "APP", "APRT", "AQR", "ARAF", "ARF6", "ARFGAP1", "ARFGAP2", "ARHGDIA", "ARHGEF1", "ARHGEF2", "ARPC1A", "ARPC2", "ARPC3", "ARPC4", "ARPC5", "ASAH1", "ASNA1", "ASNS", "ATG3", "ATG4B", "ATG7", "ATIC", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1D", "ATP6V1E1", "ATP6V1H", "AURKA", "B3GALT6", "B4GAT1", "BAIAP2", "BCAS2", "BIRC6", "BLVRA", "BNIP1", "BPNT1", "BUB1B", "BUB3", "BUD23", "BUD31", "CAB39", "CACYBP", "CAD", "CALD1", "CALM3", "CALR", "CAMK2G", "CANX", "CAPN1", "CAPN2", "CARS", "CARS2", "CASK", "CBR1", "CCDC6", "CCNB1", "CD47", "CDC16", "CDC20", "CDC23", "CDC27", "CDC34", "CDC40", "CDC42", "CDC5L", "CDC7", "CDH2", "CDIPT", "CDK1", "CDK2", "CDK4", "CDK5", "CDK6", "CDKN2A", "CDS2", "CETN2", "CFL1", "CFL2", "CHERP", "CHKA", "CHMP2A", "CHMP2B", "CHMP3", "CHMP4B", "CHMP5", "CHORDC1", "CHST14", "CKB", "CKMT1A*", "CLN5", "CLTA", "CLTC", "CMAS", "CMPK1", "CNOT1", "CNOT10", "CNOT2", "CNOT9", "COASY", "COMT", "COX2", "COX4I1", "COX5A", "COX5B", "COX6C", "COX7A2", "CPOX", "CPT1A", "CPT2", "CRK", "CRKL", "CRNKL1", "CROT", "CS", "CSK", "CSNK1A1", "CSNK2A2", "CSNK2B", "CTBP1", "CTBP2", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTPS2", "CTSA", "CTSB", "CTSC", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CWC15", "CYB5R1", "CYB5R3", "CYC1", "CYFIP1", "CYFIP2", "CYP51A1", "DAD1", "DAG1", "DARS", "DARS2", "DAXX", "DBT", "DCP1B", "DCPS", "DCTD", "DCTN1", "DCTN2", "DCTN4", "DCXR", "DDB1", "DDOST", "DDX23", "DDX39B", "DDX3X", "DDX42", "DDX46", "DDX5", "DDX6", "DEGS1", "DERL1", "DFFA", "DGKE", "DHCR24", "DHCR7", "DHFR", "DHRS4", "DHX15", "DHX16", "DHX38", "DHX8", "DIAPH1", "DIAPH2", "DIAPH3", "DIS3", "DLAT", "DLD", "DLST", "DNM1L", "DNM2", "DNMT1", "DOLPP1", "DPAGT1", "DPM1", "DPYSL2", "DPYSL5", "DSG2", "DSP", "DTYMK", "DUSP3", "DUSP9", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNC1LI2", "DYNLL2", "EARS2", "ECH1", "ECHS1", "ECI1", "ECI2", "ECSIT", "EDC3", "EDC4", "EFTUD2", "EHD1", "EHD4", "EIF4A3", "EIF4B", "EIF4E", "EIF4G1", "EIF4G2", "EIF4G3", "ELOB", "ELOC", "EMD", "ENAH", "ENDOD1", "ENO1", "ENO2", "ENOPH1", "EPB41", "EPB41L2", "EPB41L3", "EPHA7", "EPHX1", "EPHX2", "EPRS", "ERCC2", "ERCC3", "ERO1A", "ESPL1", "ETNK1", "EXO1", "EXOC3", "EXOC7", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC9", "EZR", "F11R", "FABP5", "FADS2", "FAH", "FAR1", "FARS2", "FARSA", "FARSB", "FASN", "FAU", "FDFT1", "FDPS", "FECH", "FEN1", "FH", "FLAD1", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FUCA1", "FUCA2", "G6PD", "GAA", "GABARAPL2", 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overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Protein localization 43 79 4.584653124581815 4.547407302046835e-06 25.97087378640777 74.18203883495146 1.5594110758345356 0.2555609300308859 10.717199959161563 6.26233677332747 2.0947329132902324 0.3569924888492793 2.1525159933251821e-13 0.0005688844413166 5.91090650283829e-05 6.667041727618111e-06 1.1905864306896695e-14 +Respiratory electron transport atp synthesis by chemiosmotic coupling and heat production by uncoupling proteins 31 62 4.184533700086514 2.857520553045667e-05 20.8373786407767 62.38106796116505 0.8350130317954786 0.3584533980641267 8.974357262450994 5.887120286458052 1.9056004199022172 0.3784220720284639 5.8432347595817135e-08 0.0022716089120963 0.0001135854948271 9.038042750718797e-08 9.648839416527857e-08 +Mitochondrial protein import 25 37 4.136769053520807 3.522302976532998e-05 13.468446601941748 34.5873786407767 1.6025718162972953 0.1874419874946837 6.078090089851624 2.2108812815475147 1.8878681708577505 0.2901223460226844 6.928013899255326e-11 8.566885380985011e-06 1.291201486030065e-06 1.0662927613746742e-06 1.155684664938863e-11 +Slc mediated transmembrane transport 12 20 4.069466053813116 4.712100438442057e-05 8.672330097087379 21.910194174757283 1.4735742044813558 0.239038892478899 4.348519601656105 3.146764860695784 1.3934177975338422 0.3068823132077037 0.0007031555104011 0.012501825934623 0.0714457353653021 2.595137949696244e-05 0.0009235033660304 +Sphingolipid metabolism 19 28 4.041337743567063 5.314714839532719e-05 11.00242718446602 26.135922330097088 1.1708540815039898 0.1757583754913391 4.192861933829232 2.1968580551223003 2.1941615995620167 0.2567064655985949 1.739933790327391e-10 0.0356328568827733 0.0002960935640581 1.838896925678348e-08 2.810440379661839e-10 +Respiratory electron transport 26 52 3.641063120459942 0.0002715145531557 17.473300970873787 52.5752427184466 0.7619430018929745 0.3962973483509951 7.757662405441163 5.39117119769307 1.7039672197087123 0.3858226471737118 6.627007927453871e-07 0.0846554635732882 0.0027088321101405 4.474909418234228e-06 1.01585450178547e-06 +Ion channel transport 14 26 3.380337952349647 0.000723967517846 9.031553398058252 27.74271844660194 0.8980727715308076 0.3472480807052641 4.2752930421976005 3.4432740668393595 1.4212023690700646 0.3452897078102002 0.0003431965115645 0.3274019772455256 0.183361016235644 0.1303045590934426 0.0004478806407669 +Cristae formation 11 20 3.329272022242479 0.0008707331609079 8.475728155339805 19.805825242718445 0.8613288847471563 0.2756396593916832 3.7825471979528897 1.2052333490949263 1.5890526548766304 0.3070386069824295 1.906460282203736e-06 0.0073558029266518 0.0020687914080252 3.2726981844980405e-05 2.433118765431263e-06 +The citric acid tca cycle and respiratory electron transport 34 92 3.2802687601161766 0.0010370824121233 27.99757281553398 94.17961165048544 0.4883573568636233 0.4259472248586306 12.60942373482268 7.020896123249261 1.7895370613076145 0.38969273744301 1.6181938168494228e-08 0.0009764000932441 0.0001366223120294 6.971412816149318e-09 2.950991148316922e-08 +Glycosphingolipid metabolism 10 16 3.132141055993272 0.001735364790715 7.514563106796117 15.521844660194176 0.6340330218232789 0.1371235236408302 2.3948329397108954 1.2175929202976112 2.2116324239586063 0.2290247571497847 1.338864306041371e-07 0.0108643857486399 0.0002549115058573 9.811163143918549e-06 1.8041154286822785e-07 +Mitochondrial calcium ion transport 11 15 2.872549041253188 0.0040717487662005 6.502427184466019 16.12135922330097 1.0650233237312683 0.2089377868120644 3.410790121717641 1.246287729205551 1.626144580445205 0.28031724173526 2.759818462596939e-05 0.0044823878286489 0.016724444992627 0.0013478250121693 3.336721993599713e-05 +Sphingolipid de novo biosynthesis 6 12 2.742071211101948 0.0061053103988542 4.08252427184466 10.614077669902912 1.3205451179619188 0.2079933246203462 1.939118365602947 1.3614298144224892 1.289169434780902 0.261809046515659 0.0002689054738225 1.0 0.2423974925429197 0.0005384549749284 0.0003219556331171 +Transport of small molecules 56 145 2.7187876563804925 0.0065521655927938 41.730582524271846 151.96601941747574 1.4265613612661356 0.380396759556163 14.87709311863932 12.598305121005488 1.746958952072276 0.4128488770716938 2.3777225304120112e-12 0.0020082919423095 0.0095540899013446 3.190720695230559e-06 7.292387301092537e-12 +Mitochondrial biogenesis 19 33 2.683430733572194 0.0072871068662914 10.572815533980584 33.521844660194176 0.7125383902440768 0.3998427377933914 4.798567629623383 2.9315837025395943 1.2191838320541302 0.3355715376706868 0.0054619640638898 0.0627750690965546 0.0471171920041226 0.0154579474619112 0.0021449981647796 +Transport of bile salts and organic acids metal ions and amine compounds 5 6 2.6817716637041578 0.0073233426512886 1.8349514563106797 3.995145631067961 1.0286208624357371 0.2748571167414633 1.258733277411433 1.3329199016551914 1.161382969627279 0.2758406238802445 0.0029955459245255 0.1430638950507344 0.2638774705145789 0.0008616614993304 0.0034674251690792 +Insertion of tail anchored proteins into the endoplasmic reticulum membrane 7 12 2.669262077610124 0.0076018109032216 4.016990291262136 10.99757281553398 1.1239772251284714 0.2752182956921286 1.9514004604865949 1.181365809872934 1.0815649178051203 0.2865915409883788 0.0001490846538262 1.0 0.1662183776826317 0.0736296228832766 0.0001752410424372 +Glycerophospholipid biosynthesis 13 31 2.667552872550554 0.007640586605859 9.439320388349516 29.58009708737864 1.1800609247564997 0.3081196451067344 4.809346434845489 4.094857299253986 1.3402414818469337 0.3224557628717913 0.0059344219911866 1.0 0.5620030081064878 0.3346123325624752 0.0072564295004606 +Transport of vitamins nucleosides and related molecules 4 7 2.6661931477321548 0.0076715603818575 3.2985436893203883 7.703883495145631 0.5884630304197642 0.3368828823659784 1.766928610360549 0.9135891377639136 1.2550983698791685 0.3076045725047946 0.0022225400809937 1.0 1.0 0.0013478250121693 0.0025285330610476 +Phospholipid metabolism 17 45 2.6246485178172043 0.0086738454997015 12.859223300970871 45.932038834951456 1.017004520648936 0.3949296504793965 6.241466981115118 7.362344677079641 1.3242274243570669 0.3709328103546776 0.0558192495626268 1.0 0.7774765754304399 0.7206690861802479 0.0338719405519905 +Complex i biogenesis 12 30 2.6145884271289304 0.0089335032336512 9.1747572815534 28.546116504854368 0.5440760559261008 0.4236381582634617 4.289696810672699 3.852285850983641 1.2631239118061712 0.3404380044043241 0.0002037561826904 0.2370066357192962 0.0991796010672266 0.0020222074444458 0.000258516767845 +Rac2 gtpase cycle 7 31 2.450594863665912 0.0142620376191386 8.905339805825243 34.74757281553398 0.8419178475366841 0.4471774138928159 4.131135699306596 3.707034631516275 0.9898490308362274 0.3561406142763811 0.0322534765150889 1.0 0.1799401404284943 0.0431820162236638 0.0374211197872725 +Mitophagy 5 12 2.4291412900232405 0.0151346330507193 3.662621359223301 11.783980582524272 1.3564301304992197 0.1917930287367771 1.8155907654273165 1.3363606860118669 1.2723890100166135 0.2636913304405313 0.0225944645433979 0.0001966568602221 0.0014613866465803 0.0184993148019339 0.0046973513771782 +Class i peroxisomal membrane protein import 7 11 2.4266197650561177 0.0152402191956328 4.300970873786408 9.604368932038836 1.1426576411245968 0.2560233101944223 2.515331441636984 1.9424437465598188 1.2133199793435778 0.2911424942178205 0.0013704364806795 1.0 0.1662183776826317 0.0736296228832766 0.0015626966448138 +Processing of smdt1 7 11 2.402581072793993 0.0162798254712697 4.975728155339806 11.155339805825244 0.3833102568885913 0.3649000478471426 2.609615007852169 1.2287595888742628 1.3301610577177632 0.3259664414506655 0.0346431338005326 1.0 1.0 1.0 0.0373405153007746 +Gpcr ligand binding 7 10 2.366061070672892 0.0179784784856875 3.4611650485436893 9.330097087378642 1.051447004644797 0.2131328881138611 1.5951828582954857 1.3192992367203638 1.3003237502897853 0.2397874119507845 0.3554089430944265 0.1991580424676108 0.356411341728891 0.2984142577641933 0.3728887007425893 +Slc transporter disorders 4 32 2.3391864231406565 0.0193257874345862 10.072815533980584 32.68689320388349 0.1121793221691444 0.6146102245245559 5.627130779592072 1.491569531804079 1.0244067182438623 0.3378443700099887 0.1013649825327056 1.0 1.0 0.0088741125605978 0.1112728695784481 +Rhog gtpase cycle 7 33 2.3337683255440984 0.019607856196284 9.8373786407767 35.66504854368932 0.6614029400837433 0.4973720188279035 4.308521802053122 2.993429981792782 0.9950331841901028 0.3588671909523165 0.0158215725345548 1.0 0.4939128229902693 0.0264745204980689 0.0185677520006933 +Pink1 prkn mediated mitophagy 5 9 2.2495004983071114 0.0244806711530796 3.2815533980582523 8.473300970873787 1.395617281862234 0.1554977461962819 1.6230588150315317 0.9738153254376878 1.3577427922485954 0.2414588001366878 0.006520727297513 6.765318543664244e-05 0.0005152543640852 0.0070197321203344 0.0008996004371504 +Glycosaminoglycan metabolism 8 12 2.206549732287038 0.0273455321318007 6.563106796116505 14.388349514563108 0.750167459040055 0.1742505874253542 2.387954817808654 2.3973407990867264 1.8682770414846892 0.2409021330213527 0.0412563942647226 1.0 1.0 0.231214222216266 0.047094581641612 +Synthesis of pa 2 9 2.18933280936524 0.0285726593440198 2.9635922330097086 8.558252427184467 0.9129149199765416 0.2964837496518883 1.9473992387004595 1.904008254033093 1.1909456358572703 0.2923824193190221 0.1053301957934751 1.0 0.2127898194125335 0.0206613256108628 0.1125450082361374 +Stimuli sensing channels 5 8 2.1702499105067448 0.0299879189303733 3.075242718446602 8.648058252427184 0.6737384899082146 0.3285895756392196 1.7754169999219978 1.9694070657894505 1.2463928142905627 0.307032431313504 0.0289392735921607 0.1675604235637086 0.3050454458143302 0.2276831565571508 0.0323056572403917 +Synthesis of very long chain fatty acyl coas 3 8 2.1567965699057097 0.0310215185095852 3.0800970873786406 7.662621359223301 0.2970725454313344 0.3790733377388842 1.7392923430670622 0.9085681268331954 1.2502564772465108 0.3141166423632316 0.006520727297513 1.0 1.0 0.0603828760130106 0.0072317525939857 +Class a 1 rhodopsin like receptors 6 8 2.0932550243715977 0.0363263951980405 2.8640776699029127 6.796116504854369 1.193322814833652 0.1851946070449122 1.2850789986620814 0.7987760455175396 1.3206182868906609 0.2426624676455473 0.0695538775916506 0.0963063052639835 0.1820374447866984 0.0877027952007016 0.0746022325302512 +Peptide ligand binding receptors 6 8 2.0932550243715977 0.0363263951980405 2.8640776699029127 6.796116504854369 1.193322814833652 0.1851946070449122 1.2850789986620814 0.7987760455175396 1.3206182868906609 0.2426624676455473 0.0406693637652179 0.0786913117950012 0.1500965904253892 0.0603828760130106 0.0437923930222569 +O linked glycosylation 2 5 2.0839261498297263 0.0371668853010094 1.766990291262136 4.330097087378641 0.8603336668848929 0.3169450005244383 1.1529100664253755 1.1773621125091884 1.0771631098821022 0.279831511700265 0.2165503775341354 1.0 1.0 0.2014063930762389 0.2292931386582452 +Diseases associated with n glycosylation of proteins 4 8 2.04404512381641 0.0409490895745492 2.2475728155339807 5.725728155339806 0.3341088995719526 0.3985277581822796 1.5924179977786468 1.7320559095113808 1.1764326310317936 0.3016026507368399 0.0010490281052016 1.0 1.0 0.0082779259052177 0.001197576749496 +Cholesterol biosynthesis 6 17 2.038220852533899 0.0415278510040129 5.878640776699029 16.75 1.3996798653689082 0.2350718901934974 2.503362805703168 1.8986773628384943 1.0886216368414 0.270950573691616 7.233718035537495e-06 0.1093006244161378 0.0215793786244467 9.540039985395644e-07 8.985405729806724e-06 +Regulation of insulin like growth factor igf transport and uptake by insulin like growth factor binding proteins igfbps 7 18 2.0162669976241747 0.0437720639417464 6.014563106796117 17.274271844660195 0.870961683103299 0.329566970411291 2.8591161566949044 2.4465188670593117 1.2657234914365352 0.3108311955329007 0.1138903728357159 1.0 1.0 0.147292398609956 0.1247705326810132 +Diseases of glycosylation 9 21 2.0114268911211126 0.0442803853172433 6.359223300970874 19.17718446601942 0.13180823173309 0.3045208720095976 2.4657040544471793 2.991113672999948 1.5111068586159069 0.284004628008759 0.0024043840712469 1.0 1.0 0.009204426852113 0.0029759230162326 +Peptide hormone metabolism 3 14 1.997959704992189 0.0457210288615581 4.021844660194175 14.021844660194176 0.5560275504881529 0.5205961274891826 2.4979619838894513 2.4069092486442756 0.8833525414026219 0.3339695456705046 0.1341377159928368 0.187449079081247 0.3376050929703735 0.0815041572972921 0.1448333989734842 +Synaptic adhesion like molecules 4 6 1.9937464822129456 0.046179766846409 1.6674757281553398 5.951456310679611 1.045730316736721 0.2890276876766184 1.4188777313077996 1.1438195320406324 0.8614150619700692 0.2468687149363868 0.0882392114562766 0.0516364610584135 0.0998570540504815 0.2323046488407439 0.0928255051702242 +Ras processing 2 6 1.9901001864512236 0.0465799002809983 1.3519417475728157 4.871359223300971 1.1011688928930974 0.2799307194914149 1.0191949595335985 0.8620674500492106 1.0561018280407846 0.2880746444526379 0.0541824319759991 1.0 1.0 0.0096601558647598 0.0582282885441972 +Metabolism of cofactors 2 5 1.9720902228903 0.0485993078887492 1.4004854368932038 5.589805825242719 0.8083917792774582 0.3609852370032988 1.1730384400465106 1.1078681360867626 1.0031936318469477 0.2887992775559558 0.0291172285701084 1.0 0.1336663515258769 0.3027182369322541 0.0314157626389551 +Basigin interactions 1 6 1.965794158414184 0.0493223928696846 2.4393203883495147 6.45873786407767 0.5951781716055712 0.386557720705423 1.681916245410159 0.8817163090991117 1.0576478129999063 0.2968626500881887 0.1660072045565559 1.0 1.0 0.0541048590842698 0.1738896113859001 diff --git a/msigdb_reactome/metrics.json b/msigdb_reactome/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..4f52c599493eaa38ac2cf42f8f0708730b79fc13 --- /dev/null +++ b/msigdb_reactome/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2974, + "annotations_size": 1373, + "title": "Average number of proteins per term", + "value": 18.67225054624909 +} \ No newline at end of file diff --git a/msigdb_reactome/paths.json b/msigdb_reactome/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..cc2c27581f5c64539d0a289ea56fb47ab403978d --- /dev/null +++ b/msigdb_reactome/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/msigdb_reactome/fragment/C220/C220_val_log2fc"} \ No newline at end of file diff --git a/msigdb_reactome/result.tsv b/msigdb_reactome/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..acb20401b7d113e029857dec80a4c46f3b0d83c1 --- /dev/null +++ b/msigdb_reactome/result.tsv @@ -0,0 +1,285 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Protein localization 0.6231060672001535 4.5846531245818145 4.547407302046835e-06 0.0062241536258193 0.0062435902257116 79 Q99595,Q9NX63,Q5JRX3,O60830,Q9UJS0,Q9Y512,O14925,P46379,Q10713,Q9Y5J9,O96008,Q8N4H5,Q9NS69,O43615,O43681,P21796,Q9Y5L4,Q96DA6,Q8NBU5,O75381,O00116,Q13505,P60059,Q9Y5J7,O15254,P12236,Q13190,Q9BY49,Q3ZCQ8,Q9Y5Y5,P51648,P05067,P50402,Q15388,Q9NR77,P09601,Q15067,P08574,O43808,P12235,P38646,Q9Y5J6,P40855 43 +Respiratory electron transport atp synthesis by chemiosmotic coupling and heat production by uncoupling proteins 0.5832666682284967 4.184533700086514 2.857520553045667e-05 0.0384746197254918 0.0145942069493571 62 P13073,Q86Y39,P00403,O96000,Q9UDW1,O75964,O95139,P00846,P31930,O43676,Q9Y6M9,P51970,O75438,O00483,Q8N8Q8,O14949,Q7L592,P24539,Q9P0J0,O43674,P20674,P21912,O43819,P03886,Q8N183,Q8IUX1,P56385,O75880,P08574,O95168,P22695 31 +Mitochondrial protein import 0.7103803661677089 4.136769053520807 3.522302976532998e-05 0.0472112531314393 0.0145942069493571 37 Q99595,Q9NX63,O60830,Q5JRX3,Q9UJS0,Q9Y512,O14925,Q10713,Q9Y5J9,O96008,Q8N4H5,Q9NS69,O43615,P21796,Q9Y5L4,Q96DA6,Q13505,Q9Y5J7,P12236,Q3ZCQ8,Q15388,P08574,P12235,Q9Y5J6,P38646 25 +Slc mediated transmembrane transport 0.8144751257550313 4.069466053813116 4.712100438442057e-05 0.0626501213173087 0.0145942069493571 20 O00400,P53985,Q8TAD4,Q6NXT4,Q15043,P35613,P12236,Q8TB61,Q70HW3,P12235,Q9UBX3,P05141 12 +Sphingolipid metabolism 0.7456334019970392 4.0413377435670625 5.314714839532719e-05 0.0703740461652413 0.0145942069493571 28 O15269,Q96G23,O95470,P16278,O43681,P04062,Q9NZJ7,P07602,P17900,Q9NRA0,P06865,P06280,Q13510,P51648,Q16739,P10619,P27544,O15121,Q06136 19 +Respiratory electron transport 0.5851281713375113 3.641063120459942 0.0002715145531557 0.3112246404573456 0.0465986851853594 52 P13073,Q86Y39,P00403,O96000,Q9UDW1,O95139,P31930,O43676,Q9Y6M9,P51970,O75438,O00483,Q8N8Q8,O14949,Q7L592,Q9P0J0,O43674,P21912,O43819,P03886,Q8N183,Q8IUX1,O75880,P08574,O95168,P22695 26 +Ion channel transport 0.6668361579445323 3.380337952349647 0.000723967517846 0.6300425908205942 0.0828339501668904 26 Q93050,P20020,Q4KMQ2,Q9HD20,Q9C0H2,Q9Y487,P27105,P16615,Q15904,P35670,Q9NW15,P51798,P05023,P51790 14 +Cristae formation 0.6968993520637015 3.329272022242479 0.0008707331609079 0.6976099141943697 0.0889039314842318 20 Q9NX63,P24539,Q13505,P00846,Q9Y512,P56385,Q9BUR5,Q5XKP0,P38646,O75964,Q6UXV4 11 +The citric acid tca cycle and respiratory electron transport 0.5110005455706099 3.2802687601161766 0.0010370824121233 0.7594080709010858 0.0949276101230197 92 P13073,P09622,Q86Y39,P00403,O96000,Q13423,Q9UDW1,O75964,Q9H9P8,O95139,P21796,P00846,Q9Y6M9,O43676,P51970,P35613,O75438,P11177,Q8N8Q8,O14949,P24539,P53985,Q96I99,Q9P0J0,O43674,P21912,O43819,P03886,Q8IUX1,P56385,O75880,P08574,O95168,P22695 34 +Glycosphingolipid metabolism 0.7494704473949861 3.132141055993272 0.001735364790715 0.907885751522726 0.1195151352973127 16 O43681,P10619,P04062,Q9NZJ7,P07602,P06280,P17900,Q16739,Q13510,P16278 10 +Mitochondrial calcium ion transport 0.7233593104765148 2.872549041253188 0.0040717487662005 0.9963092427463114 0.2190303560679143 15 P21796,O95202,Q8IYU8,Q9UJZ1,Q8WWC4,Q96TA2,Q10713,Q9Y277,P35232,P45880,Q99623 11 +Sphingolipid de novo biosynthesis 0.7522732912327789 2.742071211101948 0.0061053103988542 0.9997769879987316 0.2190303560679143 12 O15269,P27544,Q96G23,O95470,O15121,P51648 6 +Transport of small molecules 0.5028639122832956 2.7187876563804925 0.0065521655927938 0.9998797243994184 0.2190303560679143 145 O75477,O00400,P35610,Q9C0H2,Q9BU23,P35670,Q9H0U3,P30519,Q70HW3,Q9Y277,Q10713,P05023,Q9UBX3,P45880,P51790,P05141,Q9H2J7,P20020,P21796,Q8IYU8,Q6NXT4,Q9HD20,P35613,Q9H936,Q8WWC4,P35232,Q8TAD4,P33527,P49721,P08183,P53985,Q9Y487,P27105,Q9GZP9,P12236,P16615,P51798,P28070,O75027,Q9BUN8,Q93050,O15118,O95202,Q4KMQ2,P28072,Q15043,P09601,Q9NW15,Q15904,Q8TB61,Q9UJZ1,Q99797,Q9UBV2,P12235,P40855,Q8WTV0 56 +Mitochondrial biogenesis 0.5394211037302267 2.683430733572194 0.0072871068662914 0.9999564599899768 0.2190303560679143 33 Q9NX63,Q9Y512,O75964,P00367,Q16539,P00846,O00411,Q9BUR5,Q00059,Q6UXV4,P24539,Q13505,P06576,P54646,Q04837,P56385,Q5XKP0,P38646,Q16891 19 +Transport of bile salts and organic acids metal ions and amine compounds 0.9046495956873304 2.6817716637041578 0.0073233426512886 0.9999585883421814 0.2190303560679143 6 P53985,Q6NXT4,Q15043,P35613,Q8TAD4 5 +Insertion of tail anchored proteins into the endoplasmic reticulum membrane 0.7388688090696689 2.669262077610124 0.0076018109032216 0.9999718273725828 0.2190303560679143 12 P50402,O43681,P60059,P09601,P46379,Q13190,P51648 7 +Glycerophospholipid biosynthesis 0.5408569823565548 2.667552872550554 0.007640586605859 0.9999732989485032 0.2190303560679143 31 Q9NUQ2,Q53H12,Q8NF37,Q8N2A8,Q92604,Q8NCC3,Q8IV08,P40939,O95674,Q9UG56,Q8WUK0,Q9NQZ5,Q96N66 13 +Transport of vitamins nucleosides and related molecules 0.8849262648016744 2.6661931477321548 0.0076715603818575 0.9999744190521368 0.2190303560679143 7 O00400,P12235,P12236,Q8TB61 4 +Phospholipid metabolism 0.5044664028493329 2.6246485178172043 0.0086738454997015 0.9999936123219564 0.2190303560679143 45 Q9NUQ2,Q53H12,Q8NF37,Q8N2A8,Q92604,Q8NCC3,Q8IV08,P40939,O14735,O95674,Q10713,Q9UBF8,Q8IY17,Q9UG56,Q8WUK0,Q9NQZ5,Q96N66 17 +Complex i biogenesis 0.540906622104479 2.6145884271289304 0.0089335032336512 0.999995542026534 0.2190303560679143 30 O95139,Q8IUX1,Q9Y6M9,O43676,P51970,Q86Y39,Q9P0J0,O75438,O95168,O43674,O96000,P03886 12 +Rac2 gtpase cycle 0.5153876462169545 2.450594863665912 0.0142620376191386 0.9999999972803366 0.2293845728592449 31 P42167,Q13505,O15173,Q9Y512,Q86XL3,Q14739,Q8TAA9 7 +Mitophagy 0.6954979994163912 2.4291412900232405 0.0151346330507193 0.9999999991938116 0.2350579451179412 12 Q8N4H5,Q9NS69,Q15388,P21796,O96008 5 +Class i peroxisomal membrane protein import 0.7095893286363568 2.4266197650561177 0.0152402191956328 0.9999999993041654 0.2350579451179412 11 O75381,Q9NR77,Q8NBU5,O43808,Q9Y5Y5,P51648,P40855 7 +Processing of smdt1 0.7051904212964707 2.402581072793993 0.0162798254712697 0.9999999998368164 0.2352863197058244 11 Q8IYU8,Q9UJZ1,Q8WWC4,Q96TA2,Q10713,P35232,Q99623 7 +Gpcr ligand binding 0.7341588346729991 2.366061070672892 0.0179784784856875 0.9999999999847896 0.2365332136894937 10 P42892,Q9NZJ7,P07602,P04083,Q9BYT8,P05067,P22466 7 +Slc transporter disorders 0.5012484817039617 2.3391864231406565 0.0193257874345862 0.9999999999976906 0.2417127960299183 32 O00400,P35613,Q8NFH5,Q9BTX1 4 +Rhog gtpase cycle 0.4992341053537269 2.3337683255440984 0.019607856196284 0.9999999999984442 0.2417127960299183 33 P42167,O15173,O95202,Q86XL3,Q13190,Q14739,Q8TAA9 7 +Pink1 prkn mediated mitophagy 0.7458200033046414 2.2495004983071114 0.0244806711530796 0.9999999999999984 0.2561523392519047 9 Q8N4H5,Q9NS69,Q15388,P21796,O96008 5 +Glycosaminoglycan metabolism 0.6563970001830147 2.206549732287038 0.0273455321318007 1.0 0.2740541285909671 12 Q96L58,Q8NCH0,P54802,P06865,Q8TB61,O43505,Q7LGA3,P16278 8 +Synthesis of pa 0.7338605757269995 2.1893328093652396 0.0285726593440198 1.0 0.2747951774050438 9 Q8N2A8,Q8NF37 2 +Stimuli sensing channels 0.7626479504723721 2.1702499105067448 0.0299879189303733 1.0 0.2839545702855351 8 Q4KMQ2,Q9C0H2,P27105,Q9NW15,P51798 5 +Synthesis of very long chain fatty acyl coas 0.7598585070977055 2.1567965699057097 0.0310215185095852 1.0 0.2897452034942893 8 Q9P035,Q53GQ0,Q9NZ01 3 +Class a 1 rhodopsin like receptors 0.7467416714205402 2.0932550243715977 0.0363263951980405 1.0 0.3117258787931858 8 P42892,Q9NZJ7,P07602,P04083,P05067,P22466 6 +Peptide ligand binding receptors 0.7467416714205402 2.0932550243715977 0.0363263951980405 1.0 0.3117258787931858 8 P42892,Q9NZJ7,P07602,P04083,P05067,P22466 6 +O linked glycosylation 0.8219898064629955 2.0839261498297263 0.0371668853010094 1.0 0.3156351259345241 5 O43505,Q8N4A0 2 +Diseases associated with n glycosylation of proteins 0.7366480334072485 2.04404512381641 0.0409490895745492 1.0 0.3370991174574311 8 Q96AA3,Q9H3H5,Q9BT22,Q9BV10 4 +Cholesterol biosynthesis 0.5600918707695883 2.038220852533899 0.0415278510040129 1.0 0.3373830735414776 17 P37268,Q15800,Q14534,Q14739,Q16850,Q15392 6 +Regulation of insulin like growth factor igf transport and uptake by insulin like growth factor binding proteins igfbps 0.5424858183284886 2.0162669976241747 0.0437720639417464 1.0 0.3500894663587719 18 Q06481,O43852,Q02818,O76024,Q07065,O43493,Q9BTY2 7 +Diseases of glycosylation 0.5082203204468249 2.0114268911211126 0.0442803853172433 1.0 0.3514275667085264 21 P10619,Q8NCH0,Q96AA3,Q9H3H5,Q9BV10,O43505,Q9BT22,P16278,Q2TAA5 9 +Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane 0.8724168669589534 2.008969007325597 0.0445404206529238 1.0 0.3514597560716347 4 P12235,P12236 2 +Peptide hormone metabolism 0.5939596774740266 1.997959704992189 0.0457210288615581 1.0 0.358714129296682 14 Q8TAD4,Q6NXT4,P67812 3 +Synaptic adhesion like molecules 0.7524543949544164 1.9937464822129456 0.046179766846409 1.0 0.3602546584097703 6 O95197,P10586,P41440,O75955 4 +Ras processing 0.7516791979615763 1.990100186451223 0.0465799002809983 1.0 0.3613231812757668 6 P49354,O60725 2 +Metabolism of cofactors 0.7969464388908273 1.9720902228902997 0.0485993078887492 1.0 0.3660994138531589 5 O75208,P35270 2 +Basigin interactions 0.7465194425179407 1.965794158414184 0.0493223928696846 1.0 0.3660994138531589 6 P35613 1 +Synthesis of pg 0.8619528619528642 1.9648078594157603 0.0494364802088422 1.0 0.3660994138531589 4 Q8N2A8,Q8IV08,O95674 3 +Biosynthesis of the n glycan precursor dolichol lipid linked oligosaccharide llo and transfer to a nascent protein 0.5328777750513247 1.9475395323000213 0.0514700850934688 1.0 0.373083741170013 18 P10619,Q96AA3,Q9H3H5,Q9BV10,Q9BT22,Q86YN1 6 +Integrin cell surface interactions 0.85492506785511 1.9350485963294153 0.0529843325432595 1.0 0.3769299926523073 4 Q08722 1 +Transport of inorganic cations anions and amino acids oligopeptides 0.7131407679429548 1.928389096107248 0.0538067470741714 1.0 0.3808075450146257 8 Q9H2J7,Q9H936,Q15758,Q70HW3,Q9UBX3 5 +Metabolism of steroid hormones 0.724950081843899 1.9235840040379055 0.0544067476654999 1.0 0.3830793053575968 7 Q53GQ0,O95772,Q8NBQ5,Q14849 4 +Peroxisomal lipid metabolism 0.6083202772041056 1.855319173320468 0.0635506618272081 1.0 0.4235682460619261 11 Q9BY49,P51648,O15254,Q15067 4 +O linked glycosylation of mucins 0.8283444266221719 1.8217889929443931 0.0684870085240878 1.0 0.4409556538988979 4 O43505,Q8N4A0 2 +Formation of atp by chemiosmotic coupling 0.630744356298071 1.8102673262714255 0.0702543413652545 1.0 0.4445124916796981 10 P00846,O75964 2 +Endosomal vacuolar pathway 0.8168350168350168 1.7724159852388597 0.0763255302151351 1.0 0.4574681962147291 4 P10321,P04439,Q9UIQ6 3 +Rhod gtpase cycle 0.4568044719316703 1.769129884083304 0.0768722018373355 1.0 0.4574681962147291 27 P42167,O15173,Q8NHP6,Q14739,Q8TAA9 5 +Alpha oxidation of phytanate 0.8088483204541417 1.7380427675743273 0.0822032782415003 1.0 0.4742231135528568 4 P51648,Q9BY49 2 +Ire1alpha activates chaperones 0.4659619106475272 1.7251279287384138 0.0845044203625557 1.0 0.4785812498400173 23 Q9Y5M8,O14773,Q9NWM8,O76024,P43307 5 +Organelle biogenesis and maintenance 0.381856157587551 1.7245372947450208 0.0846108922978268 1.0 0.4785812498400173 91 Q9NX63,Q16891,Q9Y512,Q10713,O94927,Q96CS2,O75964,Q9H6D7,Q68CZ6,P00367,Q16539,P00846,O00411,P18085,P41208,O75935,Q9BUR5,O43924,Q00059,Q6UXV4,Q13505,P24539,O43805,P06576,Q13561,O95684,P54646,Q04837,P56385,Q5XKP0,A0AVF1,P53350,O75431,Q92973,P38646,A6NIH7 36 +Transferrin endocytosis and recycling 0.5859355568035236 1.7240347983705446 0.0847015613336665 1.0 0.4785812498400173 11 Q93050,P61421,Q9Y487,Q15904 4 +Zinc efflux and compartmentalization by the slc30 family 0.9377523553162888 1.7012464818771558 0.0888967128749222 1.0 0.4880319979457067 2 Q6NXT4 1 +Proton coupled monocarboxylate transport 0.934724091520862 1.6884015064648583 0.0913341814959527 1.0 0.491771887035071 2 P35613 1 +Ns1 mediated effects on host pathways 0.4247425823114224 1.640559816263962 0.1008888221464934 1.0 0.5196772595932088 32 O00505,Q9BTX1,Q8N1F7,Q9BW27,P78406,Q92621,P57740,Q8NFH5,Q99567,P52292,Q9NRG9,Q7Z3B4 12 +Heparan sulfate heparin hs gag metabolism 0.7855218855218974 1.637156692330117 0.1015977334124236 1.0 0.5196772595932088 4 P16278,Q7LGA3,P54802 3 +Insulin processing 0.5977330210828072 1.6256583433052267 0.1040223563376578 1.0 0.5217475615433768 10 Q6NXT4 1 +Retrograde transport at the trans golgi network 0.4587538780933969 1.6191727496936608 0.1054100994327231 1.0 0.5239124679572256 21 Q7Z6M1,P51151,Q8N2H4,P40616,P53365,O43493,O60499 7 +Heme degradation 0.7808710666630455 1.6169595379755914 0.1058870152350817 1.0 0.5239124679572256 4 P30519,P09601 2 +Metal ion slc transporters 0.921575227196225 1.587283347231677 0.1124484851090852 1.0 0.541252322672191 3 Q8TAD4,Q6NXT4 2 +Zinc transporters 0.921575227196225 1.587283347231677 0.1124484851090852 1.0 0.541252322672191 3 Q8TAD4,Q6NXT4 2 +Hs gag degradation 0.9044414535666218 1.559704187998653 0.1188298020122426 1.0 0.5427298215173595 2 P54802 1 +Cargo concentration in the er 0.523993452623782 1.5478121407737513 0.1216675325884695 1.0 0.5427298215173595 14 Q9HCU5,Q15363,O75396,Q15436,Q13190,P49755,Q96PC5 7 +Insulin receptor recycling 0.5837838060236583 1.5466928805261349 0.1219373206806657 1.0 0.5427298215173595 10 Q93050,Q9Y487,Q15904 3 +Er quality control compartment erqc 0.7620029385459312 1.5347673703341336 0.1248409804996866 1.0 0.5427298215173595 4 Q8WU17,Q9GZP9 2 +Attachment of gpi anchor to upar 0.6999536434921376 1.5277764892611043 0.1265680415003118 1.0 0.5427298215173595 5 Q9H490,O43292 2 +Response to elevated platelet cytosolic ca2 0.4112516142555948 1.5271055853949578 0.1267347582842664 1.0 0.5427298215173595 34 Q8NBX0,Q06481,Q12846,O43852,Q08380,Q9NZJ7,Q96JJ7,P07602,Q9NUQ9,Q9NTK5,P13473,O94919,P05067,Q9Y6I9,Q6UXV4 15 +Synthesis secretion and inactivation of glucose dependent insulinotropic polypeptide gip 0.8889636608344598 1.4938138464655526 0.1352242814250817 1.0 0.5677765700202971 2 P67812 1 +Synthesis secretion and deacylation of ghrelin 0.8889636608344598 1.4938138464655526 0.1352242814250817 1.0 0.5677765700202971 2 P67812 1 +Maturation of sars cov 2 spike protein 0.5462966948657664 1.4874627747962623 0.1368926278648203 1.0 0.5689082995683999 11 Q9H0U3,P46977 2 +Nr1h2 nr1h3 regulate gene expression linked to lipogenesis 0.8866083445491246 1.483784482925498 0.1378661049659948 1.0 0.5689082995683999 2 O00767 1 +Ion transport by p type atpases 0.5981851384272721 1.4779110956917512 0.1394315760383253 1.0 0.5703852496913319 9 P35670,P05023,Q9HD20,P16615 4 +Iron uptake and transport 0.456177502546271 1.474815862010135 0.1402620555365006 1.0 0.5703852496913319 19 Q93050,P30519,P09601,Q9Y487 4 +Cell surface interactions at the vascular wall 0.5208293105748604 1.4545824924579969 0.1457848807500315 1.0 0.5815480381922052 13 P53985,P35613,Q08722 3 +N glycan trimming in the er and calnexin calreticulin cycle 0.488349702867231 1.4508234166463283 0.1468290373690635 1.0 0.5826481742997809 16 Q8WU17,Q9UBV2,Q9GZP9,Q9BUN8 4 +Egr2 and sox10 mediated initiation of schwann cell myelination 0.6235419181892152 1.4206236185729733 0.1554262084370994 1.0 0.5889725305281079 7 Q9NR77 1 +Alpha linolenic omega3 and linoleic omega6 acid metabolism 0.6761253952581915 1.4163457795732746 0.1566742904381968 1.0 0.5892883663048004 5 Q15067,O95864 2 +Pregnenolone biosynthesis 0.6745387744738628 1.40890241674532 0.1588640248511257 1.0 0.5892883663048004 5 Q14849,O95772 2 +Pre notch processing in golgi 0.8754628071356412 1.4035323482817297 0.1604581527520006 1.0 0.5892883663048004 3 Q15363,P16615 2 +Regulation of glucokinase by glucokinase regulatory protein 0.4183408003634776 1.400450974880127 0.1613783144432665 1.0 0.5892883663048004 26 Q9BTX1,Q8N1F7,Q9BW27,Q8NFH4,Q92621,P78406,O75694,P57740,Q96EE3,Q8NFH5,Q99567,P37198,Q9NRG9,Q7Z3B4 14 +Sumoylation of ubiquitinylation proteins 0.4183408003634776 1.400450974880127 0.1613783144432665 1.0 0.5892883663048004 26 Q9BTX1,Q8N1F7,Q9BW27,Q8NFH4,Q92621,P78406,O75694,P57740,Q96EE3,Q8NFH5,Q99567,P37198,Q9NRG9,Q7Z3B4 14 +Sumoylation of sumoylation proteins 0.4183408003634776 1.400450974880127 0.1613783144432665 1.0 0.5892883663048004 26 Q9BTX1,Q8N1F7,Q9BW27,Q8NFH4,Q92621,P78406,O75694,P57740,Q96EE3,Q8NFH5,Q99567,P37198,Q9NRG9,Q7Z3B4 14 +Rhoa gtpase cycle 0.3903051608633384 1.3969531323241586 0.1624276653441516 1.0 0.5915469085345364 41 P42167,Q8NBN3,O15173,Q8TAA9,Q15904,P27105,Q13190,P41440,P30519,P02786,Q07021,Q14739,O15498,P51572,O75955 15 +Tysnd1 cleaves peroxisomal proteins 0.7158939635642613 1.3325631214937343 0.1826752142005956 1.0 0.638903093659447 4 O00116,Q15067 2 +Cargo trafficking to the periciliary membrane 0.4208259237665995 1.292177122687867 0.1962958123987503 1.0 0.6480507083445612 20 O43924,Q10713,A6NIH7 3 +Activated notch1 transmits signal to the nucleus 0.8401749663526261 1.2862805647563118 0.1983451628298529 1.0 0.6480507083445612 2 Q92542 1 +Translation of sars cov 1 structural proteins 0.6469899788472173 1.2792983322504947 0.2007920196808248 1.0 0.6486972815541906 5 Q10472 1 +Conversion from apc c cdc20 to apc c cdh1 in late anaphase 0.5371693703492951 1.2792799144254825 0.2007985030302483 1.0 0.6486972815541906 10 P30260,Q13042,Q9UJX6,Q96DE5,Q9UJX4,Q9UJX3 6 +Calnexin calreticulin cycle 0.5573757134083575 1.2549489097239734 0.2094973072318366 1.0 0.6590592559961931 9 Q8WU17,Q9UBV2,Q9GZP9 3 +Sialic acid metabolism 0.6980962486226714 1.2542087816091425 0.2097661288203469 1.0 0.6590592559961931 4 P10619 1 +Intra golgi traffic 0.4895433312140916 1.2525089476537443 0.2103844699817796 1.0 0.6594928705136608 13 Q13190,O00461,O95249,O15498 4 +Platelet calcium homeostasis 0.6973037401883524 1.2507183835450342 0.2110372409518532 1.0 0.6600321909496458 4 Q13586,P16615 2 +Cytochrome p450 arranged by substrate type 0.8326695063055811 1.2327948323945157 0.2176523198168034 1.0 0.6745747970845849 3 Q16850 1 +Fatty acyl coa biosynthesis 0.4663684328933478 1.225925076314421 0.2202268712150319 1.0 0.6794865037713231 15 O00767,Q53GQ0,Q9UMR5,P49327,Q9NZ01,P50897,Q9P035 7 +Antigen presentation folding assembly and peptide loading of class i mhc 0.4658037880862415 1.2220170105572397 0.2217011943119162 1.0 0.6807324721486462 15 Q9NZ08,P01889,P27824,P51572,P10321,P04439,Q03518 7 +Acyl chain remodelling of pg 0.8246971736204669 1.2207158336573654 0.2221936306330294 1.0 0.6807324721486462 2 Q8NF37 1 +Platelet homeostasis 0.5023162465251629 1.2198484821793942 0.2225223185370139 1.0 0.6807324721486462 11 Q13586,P16615,Q16539,P30154 4 +Metabolism of folate and pterines 0.5730018579842484 1.2116340760936894 0.2256524844640566 1.0 0.6839312608590502 8 P41440,P00374,Q9H2D1 3 +Interactions of vpr with host cellular proteins 0.3776960067780873 1.1918001510970373 0.2333396165353027 1.0 0.6904617610655102 33 P12235,Q8NFH5,P12236,Q9BTX1 4 +Sumoylation of rna binding proteins 0.3779205860370447 1.185556126144358 0.2357976372989652 1.0 0.6904617610655102 31 Q9BTX1,Q8N1F7,Q9BW27,P78406,Q92621,P61978,O75694,P57740,Q96EE3,Q8NFH5,Q99567,P07910,Q9NRG9,Q7Z3B4 14 +Metabolism of steroids 0.3623396302871486 1.1792566358414422 0.2382960000218934 1.0 0.6904617610655102 46 O00767,Q8NBQ5,P04062,P37268,Q9BWD1,Q15800,Q53GQ0,Q14849,O95772,P38435,Q14739,Q16850,Q15392,Q14534 14 +Synthesis of pips at the golgi membrane 0.5850229479471307 1.177625289867235 0.2389460230844369 1.0 0.6904617610655102 6 Q10713,Q9UBF8 2 +Transcriptional regulation by ventx 0.4767312123518816 1.169094298729816 0.2423656406965366 1.0 0.6904617610655102 13 Q13042,Q9UJX6,Q96DE5,Q9HCE1,Q9UJX4,Q9UJX3 6 +Miro gtpase cycle 0.6787090194331107 1.1688329117376566 0.242470957473408 1.0 0.6904617610655102 4 O95140,Q8IWA4 2 +Organic anion transporters 0.8119111709286795 1.1667463200971155 0.2433128308674663 1.0 0.6904617610655102 2 Q9UBX3 1 +Translation of sars cov 2 structural proteins 0.4472331549739392 1.1586786016773325 0.2465872162661904 1.0 0.6904617610655102 16 Q9H0U3,P46977,Q10472 3 +Ros and rns production in phagocytes 0.5380118352265618 1.1482558206857538 0.2508629714164612 1.0 0.6972365582080996 9 Q93050,Q9Y487 2 +Metabolism of porphyrins 0.5372593790378656 1.1441023681887756 0.2525811856754196 1.0 0.7005938746108105 9 P30519,P09601,P22830 3 +Beta oxidation of butanoyl coa to acetyl coa 0.8066904324488657 1.1295194863006952 0.2586787540397752 1.0 0.7064972471203415 3 P40939 1 +Wax and plasmalogen biosynthesis 0.6683501683501618 1.123256945536243 0.261328383637361 1.0 0.7064972471203415 4 O00116,O15228,Q6IAN0 3 +Formation of fibrin clot clotting cascade 0.7977792732166927 1.1073629063809334 0.2681370566481114 1.0 0.7134732146857692 2 P42785 1 +Intrinsic pathway of fibrin clot formation 0.7977792732166927 1.1073629063809334 0.2681370566481114 1.0 0.7134732146857692 2 P42785 1 +Cobalamin cbl vitamin b12 transport and metabolism 0.6037875763740824 1.075402473995256 0.2821945746465299 1.0 0.7380558398626269 5 P33527 1 +Phase i functionalization of compounds 0.45325221877653 1.0753598918156029 0.2822136314114196 1.0 0.7380558398626269 14 O43169,Q16850,P07099 3 +Small interfering rna sirna biogenesis 0.7921180813802084 1.0718609618276125 0.2837824867268148 1.0 0.7400446562592582 3 O75569 1 +Rac3 gtpase cycle 0.3690822214264687 1.0662285648196068 0.2863203324763004 1.0 0.7429433331865253 30 P50402,P42167,O15173,O15498,P02786,Q14739,Q8TAA9 7 +Pyruvate metabolism 0.4515698517769256 1.0639990265851968 0.2873291405113218 1.0 0.7429433331865253 14 P09622,P35613,P53985,P21796 4 +Abc transporters in lipid homeostasis 0.7870121130551864 1.0623511547050128 0.2880762994936667 1.0 0.7434751112872264 2 P40855 1 +Ra biosynthesis pathway 0.653800416768146 1.059356379641153 0.2894375073856192 1.0 0.7437398755083394 4 Q9BTZ2,Q8NBN7 2 +Metabolism of lipids 0.3951788219271117 1.0479171846141124 0.2946767640602679 1.0 0.7506330186544485 184 O15269,Q9NUQ2,Q53H12,P35610,Q96G23,O95470,Q15800,Q8NCC3,Q92604,Q53GQ0,Q9H7Z7,O95864,Q14849,O14735,O95772,Q9NZ01,Q10713,P50897,P16278,Q9NQZ5,Q8WUK0,Q16836,O43681,Q71SY5,P04062,Q9NZJ7,P30536,Q15436,P07602,Q15165,Q9NTJ5,P17900,Q8IV08,Q14534,Q14739,Q16850,P38435,Q9UBM7,Q9UG56,Q15392,O00116,P33527,O00767,P37268,P23786,Q8N2A8,Q8NBQ5,Q9UMR5,O15254,P06865,P06280,P49327,P40939,Q9BY49,Q9UBF8,Q13510,P51648,Q16739,P10619,P27544,Q8NF37,Q9BWD1,Q6Y1H2,O15121,Q15067,Q06136,O43808,O95674,Q9P035,Q8IY17,P53007,Q96N66 72 +Rnd1 gtpase cycle 0.4481652253303078 1.0410017024338007 0.2978747581177043 1.0 0.7506339916922447 14 Q8TAA9,P51648,Q9BXS4 3 +Tetrahydrobiopterin bh4 synthesis recycling salvage and regulation 0.7841757514335757 1.040548257117227 0.2980852563068001 1.0 0.7506339916922447 3 P35270 1 +Vitamin d calciferol metabolism 0.7822282059912319 1.032884015058484 0.3016581802097109 1.0 0.7506339916922447 3 P04062,P38435 2 +Incretin synthesis secretion and inactivation 0.7817170298507792 1.0308733309100977 0.302600224391754 1.0 0.7506339916922447 3 P67812 1 +Synthesis secretion and inactivation of glucagon like peptide 1 glp 1 0.7817170298507792 1.0308733309100977 0.302600224391754 1.0 0.7506339916922447 3 P67812 1 +Keratan sulfate keratin metabolism 0.5925541194454061 1.022464886728125 0.3065609234428652 1.0 0.7556699243932746 5 O43505,P16278,P06865 3 +Nr1h2 and nr1h3 mediated signaling 0.5866974371598518 0.9949097216649856 0.3197801741966248 1.0 0.7587858705733126 5 P49327,Q9HCE1,O00767 3 +Sulfur amino acid metabolism 0.4880438631815348 0.9936555692320808 0.3203905805742781 1.0 0.7587858705733126 10 Q9UBX3 1 +Pyruvate metabolism and citric acid tca cycle 0.3575941473845079 0.9893462836728708 0.3224937463409763 1.0 0.7587858705733126 32 Q9H9P8,P53985,P21796,P09622,P35613,P11177,P21912,Q13423 8 +Pre notch expression and processing 0.5082192552411553 0.9836355999973369 0.3252947146197429 1.0 0.7587858705733126 9 Q15363,Q9HCE1,P16615 3 +Creb phosphorylation 0.7678331090174999 0.982796385323028 0.3257076612438938 1.0 0.7587858705733126 2 P51812 1 +Metabolism of fat soluble vitamins 0.5839594248421645 0.9820408947714472 0.3260797017478039 1.0 0.7587858705733126 5 Q8N0U8 1 +Amino acid transport across the plasma membrane 0.763452134939705 0.9593229221749732 0.3373960912858487 1.0 0.7672867411613363 3 Q9H2J7 1 +Mucopolysaccharidoses 0.7633793335577125 0.9590389862883112 0.3375391053615784 1.0 0.7672867411613363 3 P54802,P16278 2 +Immunoregulatory interactions between a lymphoid and a non lymphoid cell 0.5696968345541633 0.9151792286867556 0.3600975471886092 1.0 0.7864867095051647 5 P10321,P04439 2 +Trafficking and processing of endosomal tlr 0.751367876760294 0.912349529332834 0.3615847490258137 1.0 0.7864867095051647 3 P07858 1 +Viral messenger rna synthesis 0.3482005484468804 0.9068612518332784 0.3644801740150094 1.0 0.7864867095051647 35 Q9BTX1,Q8N1F7,Q9BW27,P78406,Q92621,P57740,P24928,Q8NFH5,Q7Z3B4,Q99567,Q9NRG9,P35269 12 +Unwinding of dna 0.49340193766289 0.9018490555087196 0.3671370567777421 1.0 0.7864867095051647 9 Q9Y248 1 +Copii mediated vesicle transport 0.357241528616165 0.8976245193345013 0.3693857625444698 1.0 0.7864867095051647 28 Q15363,Q9HCU5,O75396,P62820,Q9H0U4,Q15436,Q13190,O15498,P49755 9 +Ptk6 regulates proteins involved in rna processing 0.7405787348586828 0.8715178074737939 0.3834714870569544 1.0 0.7864867095051647 2 Q07666 1 +Activation of ppargc1a pgc 1alpha by phosphorylation 0.735146673957995 0.8498572253912877 0.3954044694286169 1.0 0.7864867095051647 3 Q16539 1 +Cardiac conduction 0.4418812479318724 0.8480787279478743 0.3963941274512184 1.0 0.7864867095051647 11 Q13586,P16615,P05023 3 +Ion homeostasis 0.4418812479318724 0.8480787279478743 0.3963941274512184 1.0 0.7864867095051647 11 Q13586,P16615,P05023 3 +The nlrp3 inflammasome 0.6049758329523673 0.8470509777974357 0.3969667077109093 1.0 0.7864867095051647 4 P09601 1 +Purinergic signaling in leishmaniasis infection 0.6049758329523671 0.8470509777974349 0.3969667077109098 1.0 0.7864867095051647 4 P09601 1 +Inflammasomes 0.6049758329523671 0.8470509777974349 0.3969667077109098 1.0 0.7864867095051647 4 P09601 1 +Glycerophospholipid catabolism 0.7318304172274646 0.8363476344667717 0.4029593626842103 1.0 0.7940885626357257 2 Q8IY17 1 +Selective autophagy 0.3397134641865313 0.8125523899988121 0.4164747377094331 1.0 0.7993137018361023 32 Q8N4H5,Q9NS69 2 +Plasma lipoprotein assembly remodeling and clearance 0.3988960178389515 0.8118276110278845 0.4168905562988954 1.0 0.7993137018361023 16 P35610,O15118,Q8WTV0 3 +Extracellular matrix organization 0.3549430350055966 0.796650797985657 0.4256538665309963 1.0 0.7993137018361023 24 Q92542,P35613,P13674,P07858,O75718,Q32P28,Q08722 7 +Intra golgi and retrograde golgi to er traffic 0.3173669304988329 0.7934221413768902 0.4275319148954277 1.0 0.7993137018361023 97 Q7Z6M1,Q15363,P51151,O43493,Q10472,O15260,P24390,P18085,O75935,Q8TBA6,Q8N1B4,P40616,Q12981,Q86Y91,O60499,P49755,Q9P2W9,O00461,Q6NUQ1,Q8N2H4,Q13190,O15498,O95249,Q9Y3B3,Q13561,O75396,P62820,Q9H0U4,P53365 29 +Postmitotic nuclear pore complex npc reformation 0.3572811965784797 0.7890166201628144 0.4301022926295093 1.0 0.8012624800275661 22 Q8NFH5,Q9BTX1 2 +Export of viral ribonucleoproteins from nucleus 0.3446581170117529 0.7803649224660811 0.4351761087086943 1.0 0.8058282393121297 28 Q9BTX1,Q8N1F7,Q9BW27,P78406,Q92621,O75694,P57740,Q96EE3,Q8NFH5,Q99567,Q9NRG9,Q7Z3B4 12 +P38mapk events 0.7129878869448302 0.7617006893336542 0.4462386638323814 1.0 0.8066969250913527 2 Q16539 1 +Tp53 regulates metabolic genes 0.333306684541826 0.7506884482607705 0.4528401767307666 1.0 0.8066969250913527 33 Q8N8Q8,O43819,P00403,P13073 4 +Ripk1 mediated regulated necrosis 0.4452977295450678 0.7457703024106371 0.4558061825462796 1.0 0.8066969250913527 10 P41440,P49327,O00560,Q16543,O75955 5 +Negative regulation of met activity 0.4979784366576841 0.7449229522892089 0.456318298879397 1.0 0.8066969250913527 6 O14964,P18031,Q9NWH9,Q99961,P62993 5 +Plasma lipoprotein clearance 0.4112279882806141 0.7416027187655194 0.4583280758165144 1.0 0.8083983016698805 13 O15118,Q8WTV0 2 +Pi metabolism 0.3958501124028259 0.736205838644796 0.4616054395551248 1.0 0.8083983016698805 15 Q8IY17,Q10713,Q9UBF8 3 +Initiation of nuclear envelope ne reformation 0.3875410822333599 0.7308037040745462 0.4648990607514522 1.0 0.8090068573025906 16 P42167,Q86XL3,Q14739 3 +Association of tric cct with target proteins during biosynthesis 0.3706125130379709 0.7272555259680866 0.4670694370762911 1.0 0.8096196245041116 18 O95302,P04062 2 +Collagen formation 0.4131210642229611 0.7102112921270369 0.4775731194144077 1.0 0.8096196245041116 12 O75718,P13674,P07858 3 +Disorders of transmembrane transporters 0.2933735262825049 0.7038691752817968 0.4815142493314626 1.0 0.8096196245041116 75 P49721,O00400,P53985,Q9BTX1,P28072,P35613,Q9GZP9,Q8NFH5,Q9UBV2,P28070,Q9BUN8 11 +Formyl peptide receptors bind formyl peptides and many other ligands 0.6960582733805445 0.7027374844872067 0.4822193629178442 1.0 0.8096196245041116 3 P04083 1 +Asparagine n linked glycosylation 0.3234170788039941 0.7016461355020772 0.4828998724055484 1.0 0.8096196245041116 114 Q15363,Q96AA3,Q9H3H5,Q9H0U3,P16278,P24390,P46977,P27824,P18085,O75935,Q15436,P49755,Q9BT22,Q96PC5,Q2TAA5,Q9GZP9,Q13190,Q9BV10,O15498,O95249,Q9BUN8,Q86YN1,Q9HCU5,Q9Y3B3,P10619,Q13561,O75396,P62820,Q9H0U4,Q8WU17,Q9UBV2 31 +Cd28 dependent pi3k akt signaling 0.6921265141318982 0.6811258729616041 0.4957918470895668 1.0 0.8096196245041116 2 P31751 1 +Constitutive signaling by akt1 e17k in cancer 0.6921265141318982 0.6811258729616041 0.4957918470895668 1.0 0.8096196245041116 2 P31751 1 +The canonical retinoid cycle in rods twilight vision 0.6917900403768512 0.6798464603826166 0.4966016850899428 1.0 0.8096196245041116 2 Q8TC12 1 +Chondroitin sulfate dermatan sulfate metabolism 0.5650621528056193 0.6782905347745151 0.4975874988719355 1.0 0.8096196245041116 4 Q8NCH0,P06865 2 +Diseases associated with glycosaminoglycan metabolism 0.5650621528056193 0.6782905347745151 0.4975874988719355 1.0 0.8096196245041116 4 Q8NCH0,P06865 2 +Non integrin membrane ecm interactions 0.5643097643097691 0.67517249887939 0.4995661768574966 1.0 0.8096196245041116 4 P05556,O14936,P12814 3 +Beta oxidation of hexanoyl coa to butanoyl coa 0.5601715629908273 0.6580733190616348 0.5104910193710979 1.0 0.8131819485165238 4 P40939 1 +Beta oxidation of lauroyl coa to decanoyl coa coa 0.5601715629908273 0.6580733190616348 0.5104910193710979 1.0 0.8131819485165238 4 P40939 1 +Biological oxidations 0.3222378147213112 0.656678907855538 0.5113873993930964 1.0 0.8131819485165238 38 O43169,Q16850,Q99735,O14880,Q9NX62,P07099,Q8TB61,P21964,Q9NUJ1 9 +Unfolded protein response upr 0.3223275420059735 0.6526444656331121 0.5139855122444976 1.0 0.8144481690095612 37 Q9Y5M8,O14773,Q9NWM8,O76024,P43307 5 +Synthesis of substrates in n glycan biosythesis 0.4093479887810005 0.6501681265281349 0.5155836271030458 1.0 0.815284666352214 11 P10619,Q86YN1 2 +Gamma carboxylation hypusine formation and arylsulfatase activation 0.425134740984338 0.6307111405711067 0.5282294134167205 1.0 0.8250955456440924 10 P38435,Q9BU89,O60725 3 +Pexophagy 0.6749663526244984 0.6167893962417111 0.5373736470176995 1.0 0.8280740935525268 2 P50542 1 +Diseases of carbohydrate metabolism 0.4374279120236689 0.5974970516409737 0.5501755748711248 1.0 0.8329155805517693 9 P54802,P16278 2 +G alpha i signalling events 0.3344084576741178 0.5964582860563091 0.5508691127091396 1.0 0.8329155805517693 22 Q9NZJ7,P07602,P04083,P52292,P30154,P05067 6 +Aflatoxin activation and detoxification 0.6658013637250844 0.5933952064982317 0.552916696131607 1.0 0.8329155805517693 3 Q99735 1 +Ecm proteoglycans 0.6649808129214274 0.5904981295851527 0.5548567393666501 1.0 0.8329155805517693 3 P05067 1 +Inlb mediated entry of listeria monocytogenes into host cell 0.4978107106769943 0.5871871651365558 0.557078011441426 1.0 0.8329155805517693 5 Q9NWH9,Q99961,O14964,P62993 4 +Nucleotide binding domain leucine rich repeat containing receptor nlr signaling pathways 0.4172956506166149 0.5865568091326238 0.5575013973248915 1.0 0.8329155805517693 10 P09601,Q96J02,Q16539 3 +Signaling by retinoic acid 0.3955970464155353 0.5680897432531522 0.569974031945208 1.0 0.8460263198494817 11 P50416,Q8NBN7,P09622,Q9BTZ2,P11177,Q8TC12 6 +Signaling by flt3 fusion proteins 0.5373737373737255 0.5655758885242547 0.5716821224312072 1.0 0.8466930436988533 4 P62993,Q9UBW7,Q14789 3 +Reduction of cytosolic ca levels 0.6574945456162413 0.5642522620807909 0.572582464885484 1.0 0.8466930436988533 3 P16615 1 +Rhoc gtpase cycle 0.3220726114103704 0.5535594018268339 0.5798804168774374 1.0 0.8466930436988533 27 P42167,P27105,Q13190,P41440,P02786,Q14739,Q8TAA9,Q07021,O75955 9 +Aberrant regulation of mitotic exit in cancer due to rb1 defects 0.4113117260840647 0.5531270677688859 0.5801764030816672 1.0 0.8466930436988533 10 Q13042,Q9UJX6,Q96DE5,Q9UJX4,Q9UJX3 5 +Copi dependent golgi to er retrograde traffic 0.3033629785368789 0.5487225493974643 0.5831958688826004 1.0 0.8466930436988533 48 Q15363,O15260,P24390,Q9P2W9,P18085,Q12981,Q86Y91 7 +Rnd2 gtpase cycle 0.3587453458159472 0.5285268569266659 0.5971337115589725 1.0 0.8583071723118233 16 Q8TAA9,P51648,Q07065 3 +Signalling to ras 0.645156510576398 0.521768684029677 0.6018313961669537 1.0 0.8616418216238033 3 Q16539 1 +Neurotransmitter release cycle 0.4801555553332329 0.5106509811344163 0.6095954707170392 1.0 0.8656458675382748 5 P51649 1 +Signaling by insulin receptor 0.3615129146097409 0.5031545604896571 0.6148556092171646 1.0 0.8656458675382748 15 Q93050,Q9Y487,Q15904 3 +Keratan sulfate degradation 0.5184631974297493 0.4914444238863999 0.6231121507344377 1.0 0.8668014011736404 4 P16278,P06865 2 +Transport of the slbp dependant mature mrna 0.3089394056127236 0.4891646202904801 0.6247251551196038 1.0 0.8681656254850365 30 Q9BTX1,Q8N1F7,Q9BW27,P78406,Q92621,P57740,Q8NFH5,Q99567,Q9UBU9,Q9NRG9,Q7Z3B4 11 +Protein protein interactions at synapses 0.3676434038043201 0.4653642258512939 0.6416706483111851 1.0 0.8845520081639129 13 O95197,P10586,P41440,O75955 4 +Nuclear envelope breakdown 0.3015981511035758 0.4543120416565002 0.6496042502751578 1.0 0.8903361238653178 40 P50402,P42167,Q9BTX1,Q8N1F7,Q9BW27,P78406,Q92621,P57740,Q9Y2U8,P20700,Q96EE3,Q8NFH5,Q99567,P53350,P02545,Q9NRG9,Q7Z3B4 17 +Abortive elongation of hiv 1 transcript in the absence of tat 0.3653370143703772 0.4512079866027959 0.6518396540050557 1.0 0.8903361238653178 13 Q8IXH7 1 +Synthesis of pc 0.4659732367038559 0.4509301183915363 0.6520399154906948 1.0 0.8903361238653178 5 Q8NF37 1 +Syndecan interactions 0.6213396162908036 0.4428029281942811 0.6579082851530336 1.0 0.8925969125643429 3 P05556,O14936 2 +Collagen biosynthesis and modifying enzymes 0.4045014516094413 0.4263977516096787 0.6698180394642361 1.0 0.8989835466123131 9 O75718,P13674 2 +Met interacts with tns proteins 0.6177658142664928 0.4188057129712745 0.6753581292820332 1.0 0.9016272003726774 2 P05556 1 +Met activates ptk2 signaling 0.6177658142664928 0.4188057129712745 0.6753581292820332 1.0 0.9016272003726774 2 P05556 1 +Met activates pi3k akt signaling 0.6177658142664918 0.4188057129712706 0.6753581292820361 1.0 0.9016272003726774 2 P62993 1 +Rhoj gtpase cycle 0.3138813919999866 0.4182520530646808 0.6757628414164181 1.0 0.9016272003726774 20 P42167,P27105,Q9Y6M7,P02786,Q15758,Q8TAA9 6 +Regulation of pyruvate dehydrogenase pdh complex 0.4275830410587471 0.4144349951138704 0.6785555645026857 1.0 0.9016272003726774 6 P09622 1 +Miscellaneous transport and binding events 0.496489630864248 0.4089592131336499 0.6825695934018481 1.0 0.9016272003726774 4 Q9H0U3,Q9UNS2 2 +Synthesis of bile acids and bile salts via 7alpha hydroxycholesterol 0.6137281292059279 0.4059809207603276 0.6847566191580585 1.0 0.9022752764913766 2 P22307 1 +Negative regulators of ddx58 ifih1 signaling 0.4221449713077306 0.3905351603582868 0.6961408610408677 1.0 0.9127295425869484 6 Q86UT6 1 +Formation of the early elongation complex 0.3440377231693501 0.3889082972501608 0.6973439841032112 1.0 0.9127295425869484 15 Q8IXH7 1 +Cytoprotection by hmox1 0.2676091065935445 0.3807203906034913 0.7034107368506557 1.0 0.9154340679582468 61 P49721,P13073,P09601,P30519,P00403,Q8N8Q8,P28070,O43819,P33527 9 +G1 s specific transcription 0.394988669726133 0.3788420355779081 0.7048051700779914 1.0 0.915619854594258 9 Q9Y619 1 +Interleukin 4 and interleukin 13 signaling 0.3575946516946564 0.3744926833383639 0.7080377990994675 1.0 0.9164415314303384 12 P08670,P04083,P09601 3 +Gene silencing by rna 0.2866803408721251 0.341425324087927 0.7327834133599429 1.0 0.9264379618261523 46 Q9BTX1,Q8N1F7,P78406,Q8N2A8,Q92621,Q15631,P57740,P24928,Q8NFH5,Q99567,Q9Y2W6,O75569,Q7Z3B4 13 +Ldl clearance 0.354748400869068 0.3346290939917598 0.7379048951357898 1.0 0.9311979972623524 11 O15118 1 +Apc cdc20 mediated degradation of nek2a 0.3421821653367141 0.3130571641469972 0.7542372325122615 1.0 0.9405701364571616 13 Q13042,Q9UJX6,Q96DE5,Q9UJX4,O60566,Q9UJX3 6 +Inhibition of the proteolytic activity of apc c required for the onset of anaphase by mitotic spindle checkpoint components 0.3421821653367141 0.3130571641469972 0.7542372325122615 1.0 0.9405701364571616 13 Q13042,Q9UJX6,Q96DE5,Q9UJX4,O60566,Q9UJX3 6 +Activation of kainate receptors upon glutamate binding 0.5783983849259837 0.3015720793719494 0.7629782950090014 1.0 0.9469113750794196 2 Q92796 1 +Beta oxidation of pristanoyl coa 0.4655402266456601 0.301006133141212 0.7634098177224287 1.0 0.9469113750794196 4 O15254 1 +Energy dependent regulation of mtor by lkb1 ampk 0.3936636332996338 0.2854122102587901 0.7753283539776368 1.0 0.9469113750794196 7 Q6IAA8,P54619,P54646,Q15382,Q9Y376,P42345 6 +Platelet sensitization by ldl 0.3950137186542245 0.2765071199161319 0.7821585918403446 1.0 0.948678221375259 6 Q16539 1 +Nuclear import of rev protein 0.2849548678248057 0.2683678314538796 0.7884161983576257 1.0 0.9537404760749076 30 Q9BTX1,Q8N1F7,Q9BW27,P78406,Q92621,O75694,P57740,Q96EE3,Q8NFH5,Q99567,Q9NRG9,Q7Z3B4 12 +Rab geranylgeranylation 0.3177754090270416 0.2571874259367206 0.7970340902634601 1.0 0.9599366718699393 16 P51151,P61020,P62820,Q9H0U4,Q13636,P61026,Q969Q5 7 +Lysine catabolism 0.3853692446570679 0.2507805857682604 0.8019837523341702 1.0 0.9629478093701344 7 Q9BQT8 1 +Listeria monocytogenes entry into host cells 0.3798449612403045 0.2282919797476528 0.8194192591867686 1.0 0.9744433471528298 7 O14964,O60716,Q9NWH9,Q99961,Q92783,P62993 6 +Signaling by erbb4 0.4053740407456616 0.220281071368226 0.8256522609796706 1.0 0.9764173594531332 5 Q92542 1 +Recruitment of mitotic centrosome proteins and complexes 0.2765507801327303 0.2090554691016953 0.8344049370641435 1.0 0.9792260146851792 31 P30153,Q13561,O95684,P41208,O75935,Q9BSJ2,P53350,O94927,O43805,Q96CS2,Q9H6D7,Q68CZ6 12 +Activation of the pre replicative complex 0.2976977901345189 0.2011618516214944 0.8405720197155215 1.0 0.9834621708248824 18 Q9Y619 1 +Apoptotic factor mediated response 0.3989367960724639 0.1987273800557865 0.8424760049901565 1.0 0.9844421743416892 5 Q9NR28 1 +Methionine salvage pathway 0.4302544039591919 0.1924794921377033 0.8473666304661396 1.0 0.9884744125998384 4 Q13126,Q9UHY7 2 +Defects in cobalamin b12 metabolism 0.4289562289562212 0.1888242913762118 0.8502305325461843 1.0 0.9909732777469532 4 Q99707,Q9NPF0,Q96EY8 3 +Post translational modification synthesis of gpi anchored proteins 0.3651012419274029 0.1707340988577195 0.8644328494653748 1.0 0.9987587191489676 7 O43292,Q9H490 2 +Nuclear pore complex npc disassembly 0.2751897520679079 0.1701248421494751 0.8649119570780206 1.0 0.9987587191489676 29 Q9BTX1,Q8N1F7,Q9BW27,P78406,Q92621,O75694,P57740,Q96EE3,Q8NFH5,Q99567,Q9NRG9,Q7Z3B4 12 +Visual phototransduction 0.3611987141469703 0.1654449582011253 0.868593769682162 1.0 1.0 8 P49354,Q8TC12,Q6NUM9,P49356 4 +Prevention of phagosomal lysosomal fusion 0.4188552188552158 0.1612639016404766 0.8718855534081831 1.0 1.0 4 O14964,P20339,P51149 3 +Vitamin b5 pantothenate metabolism 0.4145506977447971 0.1500030196977556 0.8807622328433542 1.0 1.0 4 P49327,Q9NRN7 2 +Assembly of the hiv virion 0.5107671601615076 0.1467365786564018 0.883339945502734 1.0 1.0 2 Q99816 1 +Cytosolic sulfonation of small molecules 0.4130215009688277 0.1460734964640093 0.8838633687289927 1.0 1.0 4 Q8TB61 1 +Diseases of mitotic cell cycle 0.3077290969908862 0.146063699630404 0.8838711025253474 1.0 1.0 14 Q13042,Q9UJX6,Q96DE5,P11802,Q9UJX4,Q9UJX3 6 +Acyl chain remodelling of ps 0.5100942126514176 0.1455182744934877 0.8843016883599788 1.0 1.0 2 Q6P1A2 1 +Free fatty acids regulate insulin secretion 0.5063930013459047 0.1389330476832755 0.8895030559326402 1.0 1.0 2 O95573 1 +Vitamin c ascorbate metabolism 0.5050471063257095 0.136586806224261 0.8913574058619944 1.0 1.0 2 P00387 1 +Adora2b mediated anti inflammatory cytokines production 0.354903943377153 0.1332022694486646 0.8940334160819392 1.0 1.0 7 Q9UBI6,P17612,P10644,P08754,P04899,Q9Y3E5 6 +Dap12 interactions 0.3709882465183342 0.1132540635906269 0.9098291347926204 1.0 1.0 5 P10321 1 +Runx3 regulates p14 arf 0.4872139973082123 0.1079166958904952 0.9140617730628164 1.0 1.0 2 P25440 1 +Amino acids regulate mtorc1 0.3050552224302953 0.0980568949316031 0.9218871153742716 1.0 1.0 12 Q6IAA8,Q15382,Q96EE3,P42345,P36543,P61421,P21283 7 +Pi5p regulates tp53 acetylation 0.4720726783310926 0.0870337160710045 0.9306447122318212 1.0 1.0 2 Q8TBX8 1 +Activation of atr in response to replication stress 0.2838834664670224 0.0843271163999954 0.9327963534120928 1.0 1.0 17 Q9Y619 1 +Ptk6 regulates cell cycle 0.4666890982503412 0.0803497895370431 0.935959059864904 1.0 1.0 2 P11802 1 +Gene and protein expression by jak stat signaling after interleukin 12 stimulation 0.2676038361902983 0.0794783906420941 0.936652119002074 1.0 1.0 23 P14174,O14979,P52597,Q13126,P22626 5 +Rora activates gene expression 0.4633243606998702 0.0763644656830147 0.939129139303644 1.0 1.0 2 P50416 1 +Microrna mirna biogenesis 0.3023962200472461 0.0758926072924582 0.939504538424274 1.0 1.0 11 O15514,Q9HAV4,P19387,P61218,P24928,P62875,P62826,P19388,P30876,O75569 10 +Aberrant regulation of mitotic g1 s transition in cancer due to rb1 defects 0.4668461797374583 0.0717580813008215 0.9427944330543424 1.0 1.0 3 P11802,Q00534 2 +Negative regulation of nmda receptor mediated neuronal transmission 0.3771850959533419 0.0650228983131963 0.9481557686143358 1.0 1.0 4 Q14012 1 +Cilium assembly 0.2473352520191871 0.0637945559696264 0.9491338131377344 1.0 1.0 58 A6NIH7,Q13561,O95684,P18085,Q92973,P41208,O75935,O43924,Q10713,O94927,O43805,A0AVF1,Q96CS2,Q9H6D7 14 +Interferon alpha beta signaling 0.3216539944283516 0.0592238680934438 0.9527737990163208 1.0 1.0 9 P10321,P01889,P04439 3 +Peroxisomal protein import 0.2638393001133146 0.0562687289174407 0.955127730060652 1.0 1.0 21 O75381,O00116,O15254,Q15067 4 +Traf3 dependent irf activation pathway 0.4424629878869463 0.0548154896210533 0.9562854600231596 1.0 1.0 2 Q7Z434 1 +G alpha s signalling events 0.3700336700336707 0.0514414725261312 0.9589737382044914 1.0 1.0 4 P04899,Q9UBI6,Q9Y3E5 3 +Nuclear envelope ne reassembly 0.2564476276209878 0.0513950735908959 0.959010710292112 1.0 1.0 49 P42167,Q9BTX1,Q86XL3,Q8NFH5,Q14739,Q92973 6 +Receptor mediated mitophagy 0.4496802423426271 0.048793966837626 0.9610834902154852 1.0 1.0 3 P19784,Q96HS1 2 +Maturation of sars cov 2 nucleoprotein 0.3656565656565613 0.0435576641479177 0.9652569987619024 1.0 1.0 4 P78362,P48729,Q99873 3 +Dex h box helicases activate type i ifn and inflammatory cytokines production 0.4266487213997287 0.0418557907633434 0.966613659349446 1.0 1.0 2 Q9H2U1 1 +Nod1 2 signaling pathway 0.3222374736366743 0.0298322758208496 0.976200817833206 1.0 1.0 6 Q16539 1 +Regulation of insulin secretion 0.3129848229342299 0.0288140995935655 0.9770128556999034 1.0 1.0 9 P13861,Q9UBI6,O43865,O95573,P17612,P10644,P04899,O60488 8 +Anchoring of the basal body to the plasma membrane 0.2566256096179933 0.0287756989704054 0.9770434822646636 1.0 1.0 30 P30153,Q13561,O95684,P41208,O75935,P53350,O94927,O43805,Q96CS2,Q9H6D7,Q68CZ6 11 +Traf6 mediated nf kb activation 0.321765498652294 0.0285813059672108 0.9771985216707018 1.0 1.0 6 Q7Z434,Q12933,P09429,Q14258,P05067 5 +Vasopressin regulates renal water homeostasis via aquaporins 0.3545454545454522 0.0249978083467103 0.9800567117495153 1.0 1.0 4 P17612,Q9UBI6,P10644 3 +Glucagon signaling in metabolic regulation 0.3545454545454522 0.0249978083467103 0.9800567117495153 1.0 1.0 4 P17612,Q9UBI6,P10644 3 +Nr1h3 nr1h2 regulate gene expression linked to cholesterol transport and efflux 0.4222940341498097 0.0195643894961094 0.9843908714580952 1.0 1.0 3 Q9HCE1 1 +Aspartate and asparagine metabolism 0.3319847858103056 0.0184000827407831 0.9853196864369176 1.0 1.0 5 Q9UJS0 1 +Abc family proteins mediated transport 0.2512673246025425 0.0160139285173687 0.987223279770125 1.0 1.0 51 P49721,Q9BUN8,P28072,Q9GZP9,Q9UBV2,P28070,O75027,P40855,O75477,P33527 10 +Adenylate cyclase inhibitory pathway 0.3697846567967716 0.0143037066084367 0.9885876824886636 1.0 1.0 2 P04899 1 +Constitutive signaling by overexpressed erbb2 0.4150117805452626 0.0132215221712716 0.9894510589311468 1.0 1.0 3 Q16543,P62993 2 +Platelet activation signaling and aggregation 0.2490281751952616 0.012881954021429 0.9897219720382276 1.0 1.0 53 Q8NBX0,Q06481,Q12846,O43852,Q16539,Q08380,Q9NZJ7,Q96JJ7,P07602,Q8N2K0,Q9NUQ9,Q9NTK5,P13473,O94919,Q9Y6I9,Q6UXV4 16 +Depolymerisation of the nuclear lamina 0.2946415350463276 0.0012340392255578 0.9990153794044077 1.0 1.0 10 P42167 1 diff --git a/msigdb_reactome/selections.json b/msigdb_reactome/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..f1754452f5734eb04928e629a5ceb25cecef5a68 --- /dev/null +++ b/msigdb_reactome/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["2 ltr circle formation", "A tetrasaccharide linker sequence is required for gag synthesis", "Abacavir metabolism", "Abacavir transmembrane transport", "Abacavir transport and metabolism", "Abc family proteins mediated transport", "Abc transporter disorders", "Abc transporters in lipid homeostasis", "Aberrant regulation of mitotic exit in cancer due to rb1 defects", "Aberrant regulation of mitotic g1 s transition in cancer due to rb1 defects", "Abortive elongation of hiv 1 transcript in the absence of tat", "Activated notch1 transmits signal to the nucleus", "Activated ntrk2 signals through cdk5", "Activated ntrk2 signals through frs2 and frs3", "Activated ntrk2 signals through fyn", "Activated ntrk2 signals through pi3k", "Activated ntrk2 signals through ras", "Activated ntrk3 signals through ras", "Activated pkn1 stimulates transcription of ar androgen receptor regulated genes klk2 and klk3", "Activated tak1 mediates p38 mapk activation", "Activation of ampk downstream of nmdars", "Activation of anterior hox genes in hindbrain development during early embryogenesis", "Activation of atr in response to replication stress", "Activation of bad and translocation to mitochondria", "Activation of bh3 only proteins", "Activation of gene expression by srebf srebp", "Activation of irf3 irf7 mediated by tbk1 ikk epsilon", "Activation of kainate receptors upon glutamate binding", "Activation of nima kinases nek9 nek6 nek7", "Activation of nmda receptors and postsynaptic events", "Activation of noxa and translocation to mitochondria", "Activation of ppargc1a pgc 1alpha by phosphorylation", "Activation of puma and translocation to mitochondria", "Activation of rac1", "Activation of rac1 downstream of nmdars", "Activation of smo", "Activation of the ap 1 family of transcription factors", "Activation of the mrna upon binding of the cap binding complex and eifs and subsequent binding to 43s", "Activation of the pre replicative complex", "Acyl chain remodeling of cl", "Acyl chain remodelling of pc", "Acyl chain remodelling of pe", "Acyl chain remodelling of pg", "Acyl chain remodelling of pi", "Acyl chain remodelling of ps", "Adaptive immune system", "Adenylate cyclase inhibitory pathway", "Adherens junctions interactions", "Adora2b mediated anti inflammatory cytokines production", "Adp signalling through p2y purinoceptor 1", "Adp signalling through p2y purinoceptor 12", "Adrenaline noradrenaline inhibits insulin secretion", "Advanced glycosylation endproduct receptor signaling", "Aflatoxin activation and detoxification", "Aggrephagy", "Akt phosphorylates targets in the cytosol", "Akt phosphorylates targets in the nucleus", "Alk mutants bind tkis", "Alpha linolenic omega3 and linoleic omega6 acid metabolism", "Alpha oxidation of phytanate", "Alpha protein kinase 1 signaling pathway", "Amino acid transport across the plasma membrane", "Amino acids regulate mtorc1", "Ampk inhibits chrebp transcriptional activation activity", "Amyloid fiber formation", "Anchoring of the basal body to the plasma membrane", "Androgen biosynthesis", "Anti inflammatory response favouring leishmania parasite infection", "Antigen activates b cell receptor bcr leading to generation of second messengers", "Antigen presentation folding assembly and peptide loading of class i mhc", "Antigen processing cross presentation", "Antigen processing ubiquitination proteasome degradation", "Antimicrobial peptides", "Antiviral mechanism by ifn stimulated genes", "Apc c cdc20 mediated degradation of cyclin b", "Apc c cdh1 mediated degradation of cdc20 and other apc c cdh1 targeted proteins in late mitosis early g1", "Apc c mediated degradation of cell cycle proteins", "Apc cdc20 mediated degradation of nek2a", "Apex1 independent resolution of ap sites via the single nucleotide replacement pathway", "Apobec3g mediated resistance to hiv 1 infection", "Apoptosis", "Apoptosis induced dna fragmentation", "Apoptotic cleavage of cell adhesion proteins", "Apoptotic cleavage of cellular proteins", "Apoptotic execution phase", "Apoptotic factor mediated response", "Aquaporin mediated transport", "Arachidonate production from dag", "Arachidonic acid metabolism", "Arms mediated activation", "Aryl hydrocarbon receptor signalling", "Asparagine n linked glycosylation", "Aspartate and asparagine metabolism", "Assembly and cell surface presentation of nmda receptors", "Assembly of active lpl and lipc lipase complexes", "Assembly of collagen fibrils and other multimeric structures", "Assembly of the hiv virion", "Assembly of the orc complex at the origin of replication", "Association of tric cct with target proteins during biosynthesis", "Asymmetric localization of pcp proteins", "Atf4 activates genes in response to endoplasmic reticulum stress", "Atf6 atf6 alpha activates chaperone genes", "Atf6 atf6 alpha activates chaperones", "Attachment and entry", "Attachment of gpi anchor to upar", "Attenuation phase", "Auf1 hnrnp d0 binds and destabilizes mrna", "Aurka activation by tpx2", "Autophagy", "B wich complex positively regulates rrna expression", "Base excision repair", "Base excision repair ap site formation", "Basigin interactions", "Bbsome mediated cargo targeting to cilium", "Beta catenin independent wnt signaling", "Beta catenin phosphorylation cascade", "Beta oxidation of butanoyl coa to acetyl coa", "Beta oxidation of decanoyl coa to octanoyl coa coa", "Beta oxidation of hexanoyl coa to butanoyl coa", "Beta oxidation of lauroyl coa to decanoyl coa coa", "Beta oxidation of octanoyl coa to hexanoyl coa", "Beta oxidation of pristanoyl coa", "Beta oxidation of very long chain fatty acids", "Bh3 only proteins associate with and inactivate anti apoptotic bcl 2 members", "Bicarbonate transporters", "Bile acid and bile salt metabolism", "Binding and uptake of ligands by scavenger receptors", "Binding of tcf lef ctnnb1 to target gene promoters", "Biological oxidations", "Biosynthesis of epa derived spms", "Biosynthesis of maresins", "Biosynthesis of specialized proresolving mediators spms", "Biosynthesis of the n glycan precursor dolichol lipid linked oligosaccharide llo and transfer to a nascent protein", "Biotin transport and metabolism", "Bmal1 clock npas2 activates circadian gene expression", "Branched chain amino acid catabolism", "Budding and maturation of hiv virion", "Butyrate response factor 1 brf1 binds and destabilizes mrna", "C type lectin receptors clrs", "Ca dependent events", "Ca2 pathway", "Calcineurin activates nfat", "Calnexin calreticulin cycle", "Camk iv mediated phosphorylation of creb", "Carboxyterminal post translational modifications of tubulin", "Cardiac conduction", "Cargo concentration in the er", "Cargo recognition for clathrin mediated endocytosis", "Cargo trafficking to the periciliary membrane", "Carnitine metabolism", "Caspase activation via death receptors in the presence of ligand", "Caspase activation via extrinsic apoptotic signalling pathway", "Caspase mediated cleavage of cytoskeletal proteins", "Cd163 mediating an anti inflammatory response", "Cd209 dc sign signaling", "Cd28 co stimulation", "Cd28 dependent pi3k akt signaling", "Cd28 dependent vav1 pathway", "Cdc42 gtpase cycle", "Cdc6 association with the orc origin complex", "Cdt1 association with the cdc6 orc origin complex", "Cell cell communication", "Cell cell junction organization", "Cell cycle", "Cell cycle checkpoints", "Cell cycle mitotic", "Cell death signalling via nrage nrif and nade", "Cell extracellular matrix interactions", "Cell junction organization", "Cell surface interactions at the vascular wall", "Cellular response to chemical stress", "Cellular response to heat stress", "Cellular response to hypoxia", "Cellular response to starvation", "Cellular responses to stimuli", "Cellular senescence", "Chaperone mediated autophagy", "Chk1 chk2 cds1 mediated inactivation of cyclin b cdk1 complex", "Chl1 interactions", "Cholesterol biosynthesis", "Choline catabolism", "Chondroitin sulfate dermatan sulfate metabolism", "Chrebp activates metabolic gene expression", "Chromatin modifying enzymes", "Chromosome maintenance", "Chylomicron assembly", "Cilium assembly", "Circadian clock", "Citric acid cycle tca cycle", "Class a 1 rhodopsin like receptors", "Class b 2 secretin family receptors", "Class i mhc mediated antigen processing presentation", "Class i peroxisomal membrane protein import", "Clathrin mediated endocytosis", "Clec7a dectin 1 induces nfat activation", "Clec7a dectin 1 signaling", "Cobalamin cbl vitamin b12 transport and metabolism", "Coenzyme a biosynthesis", "Cohesin loading onto chromatin", "Collagen biosynthesis and modifying enzymes", "Collagen degradation", "Collagen formation", "Competing endogenous rnas cernas regulate pten translation", "Complement cascade", "Complex i biogenesis", "Condensation of prometaphase chromosomes", "Condensation of prophase chromosomes", "Constitutive signaling by aberrant pi3k in cancer", "Constitutive signaling by akt1 e17k in cancer", "Constitutive signaling by egfrviii", "Constitutive signaling by ligand responsive egfr cancer variants", "Constitutive signaling by overexpressed erbb2", "Conversion from apc c cdc20 to apc c cdh1 in late anaphase", "Cooperation of pdcl phlp1 and tric cct in g protein beta folding", "Cooperation of prefoldin and tric cct in actin and tubulin folding", "Copi dependent golgi to er retrograde traffic", "Copi independent golgi to er retrograde traffic", "Copi mediated anterograde transport", "Copii mediated vesicle transport", "Costimulation by the cd28 family", "Creatine metabolism", "Creb phosphorylation", "Creb1 phosphorylation through nmda receptor mediated activation of ras signaling", "Creb1 phosphorylation through the activation of adenylate cyclase", "Creb1 phosphorylation through the activation of camkii camkk camkiv cascasde", "Cristae formation", "Crmps in sema3a signaling", "Cross presentation of soluble exogenous antigens endosomes", "Cs ds degradation", "Ctla4 inhibitory signaling", "Cyclin a b1 b2 associated events during g2 m transition", "Cyclin a cdk2 associated events at s phase entry", "Cyclin d associated events in g1", "Cytochrome c mediated apoptotic response", "Cytochrome p450 arranged by substrate type", "Cytokine signaling in immune system", "Cytoprotection by hmox1", "Cytosolic iron sulfur cluster assembly", "Cytosolic sensors of pathogen associated dna", "Cytosolic sulfonation of small molecules", "Cytosolic trna aminoacylation", "Dag and ip3 signaling", "Dap12 interactions", "Dap12 signaling", "Darpp 32 events", "Dcc mediated attractive signaling", "Ddx58 ifih1 mediated induction of interferon alpha beta", "Deactivation of the beta catenin transactivating complex", "Deadenylation dependent mrna decay", "Deadenylation of mrna", "Death receptor signalling", "Dectin 1 mediated noncanonical nf kb signaling", "Defective cftr causes cystic fibrosis", "Defective chst14 causes eds musculocontractural type", "Defective factor ix causes hemophilia b", "Defective intrinsic pathway for apoptosis", "Defective ripk1 mediated regulated necrosis", "Defects in biotin btn metabolism", "Defects in cobalamin b12 metabolism", "Defects in vitamin and cofactor metabolism", "Defects of contact activation system cas and kallikrein kinin system kks", "Degradation of axin", "Degradation of beta catenin by the destruction complex", "Degradation of cysteine and homocysteine", "Degradation of dvl", "Degradation of gli1 by the proteasome", "Degradation of the extracellular matrix", "Depolymerisation of the nuclear lamina", "Deposition of new cenpa containing nucleosomes at the centromere", "Dermatan sulfate biosynthesis", "Detoxification of reactive oxygen species", "Deubiquitination", "Developmental biology", "Dex h box helicases activate type i ifn and inflammatory cytokines production", "Digestion", "Digestion and absorption", "Disassembly of the destruction complex and recruitment of axin to the membrane", "Diseases associated with glycosaminoglycan metabolism", "Diseases associated with glycosylation precursor biosynthesis", "Diseases associated with n glycosylation of proteins", "Diseases associated with o glycosylation of proteins", "Diseases of base excision repair", "Diseases of carbohydrate metabolism", "Diseases of dna repair", "Diseases of glycosylation", "Diseases of immune system", "Diseases of metabolism", "Diseases of mismatch repair mmr", "Diseases of mitotic cell cycle", "Diseases of programmed cell death", "Diseases of signal transduction by growth factor receptors and second messengers", "Disinhibition of snare formation", "Disorders of transmembrane transporters", "Displacement of dna glycosylase by apex1", "Dissolution of fibrin clot", "Dna damage bypass", "Dna damage recognition in gg ner", "Dna damage reversal", "Dna damage telomere stress induced senescence", "Dna double strand break repair", "Dna double strand break response", "Dna methylation", "Dna repair", "Dna replication", "Dna replication initiation", "Dna replication pre initiation", "Dna strand elongation", "Dopamine clearance from the synaptic cleft", "Dopamine neurotransmitter release cycle", "Downregulation of erbb2 erbb3 signaling", "Downregulation of erbb2 signaling", "Downregulation of erbb4 signaling", "Downregulation of smad2 3 smad4 transcriptional activity", "Downregulation of tgf beta receptor signaling", "Downstream signal transduction", "Downstream signaling events of b cell receptor bcr", "Downstream signaling of activated fgfr1", "Downstream signaling of activated fgfr2", "Downstream signaling of activated fgfr3", "Downstream signaling of activated fgfr4", "Dscam interactions", "Dual incision in gg ner", "Dual incision in tc ner", "E2f enabled inhibition of pre replication complex formation", "E2f mediated regulation of dna replication", "E3 ubiquitin ligases ubiquitinate target proteins", "Early phase of hiv life cycle", "Ecm proteoglycans", "Effects of pip2 hydrolysis", "Egfr downregulation", "Egfr interacts with phospholipase c gamma", "Egfr transactivation by gastrin", "Egr2 and sox10 mediated initiation of schwann cell myelination", "Elastic fibre formation", "Elevation of cytosolic ca2 levels", "Endogenous sterols", "Endosomal sorting complex required for transport escrt", "Endosomal vacuolar pathway", "Energy dependent regulation of mtor by lkb1 ampk", "Enos activation", "Eph ephrin mediated repulsion of cells", "Eph ephrin signaling", "Epha mediated growth cone collapse", "Ephb mediated forward signaling", "Ephrin signaling", "Epigenetic regulation of gene expression", "Er quality control compartment erqc", "Er to golgi anterograde transport", "Erbb2 regulates cell motility", "Ercc6 csb and ehmt2 g9a positively regulate rrna expression", "Erk mapk targets", "Erks are inactivated", "Erythrocytes take up carbon dioxide and release oxygen", "Erythropoietin activates phospholipase c gamma plcg", "Erythropoietin activates ras", "Esr mediated signaling", "Establishment of sister chromatid cohesion", "Estrogen biosynthesis", "Estrogen dependent gene expression", "Estrogen dependent nuclear events downstream of esr membrane signaling", "Estrogen stimulated signaling through prkcz", "Ethanol oxidation", "Eukaryotic translation elongation", "Eukaryotic translation initiation", "Export of viral ribonucleoproteins from nucleus", "Extension of telomeres", "Extra nuclear estrogen signaling", "Extracellular matrix organization", "Factors involved in megakaryocyte development and platelet production", "Fanconi anemia pathway", "Fasl cd95l signaling", "Fatty acid metabolism", "Fatty acyl coa biosynthesis", "Fbxw7 mutants and notch1 in cancer", "Fc epsilon receptor fceri signaling", "Fceri mediated ca 2 mobilization", "Fceri mediated mapk activation", "Fceri mediated nf kb activation", "Fcgamma receptor fcgr dependent phagocytosis", "Fcgr3a mediated il10 synthesis", "Fgfr1 mutant receptor activation", "Fgfr2 alternative splicing", "Fgfr2 mutant receptor activation", "Fibronectin matrix formation", "Flt3 signaling", "Flt3 signaling in disease", "Folding of actin by cct tric", "Formation of apoptosome", "Formation of atp by chemiosmotic coupling", "Formation of fibrin clot clotting cascade", "Formation of incision complex in gg ner", "Formation of rna pol ii elongation complex", "Formation of senescence associated heterochromatin foci sahf", "Formation of tc ner pre incision complex", "Formation of the beta catenin tcf transactivating complex", "Formation of the cornified envelope", "Formation of the early elongation complex", "Formation of tubulin folding intermediates by cct tric", "Formation of xylulose 5 phosphate", "Formyl peptide receptors bind formyl peptides and many other ligands", "Foxo mediated transcription", "Foxo mediated transcription of oxidative stress metabolic and neuronal genes", "Free fatty acids regulate insulin secretion", "Frs mediated fgfr1 signaling", "Frs mediated fgfr2 signaling", "Frs mediated fgfr3 signaling", "Frs mediated fgfr4 signaling", "Fructose metabolism", "G alpha 12 13 signalling events", "G alpha i signalling events", "G alpha q signalling events", "G alpha s signalling events", "G alpha z signalling events", "G beta gamma signalling through cdc42", "G beta gamma signalling through pi3kgamma", "G protein activation", "G protein beta gamma signalling", "G protein mediated events", "G0 and early g1", "G1 s dna damage checkpoints", "G1 s specific transcription", "G2 m checkpoints", "G2 m dna damage checkpoint", "G2 m dna replication checkpoint", "G2 phase", "Gab1 signalosome", "Gaba b receptor activation", "Gaba receptor activation", "Gaba synthesis release reuptake and degradation", "Galactose catabolism", "Gamma carboxylation hypusine formation and arylsulfatase activation", "Gamma carboxylation transport and amino terminal cleavage of proteins", "Gap filling dna repair synthesis and ligation in gg ner", "Gap junction assembly", "Gap junction degradation", "Gap junction trafficking and regulation", "Gastrin creb signalling pathway via pkc and mapk", "Gene and protein expression by jak stat signaling after interleukin 12 stimulation", "Gene silencing by rna", "Generation of second messenger molecules", "Global genome nucleotide excision repair gg ner", "Glucagon like peptide 1 glp1 regulates insulin secretion", "Glucagon signaling in metabolic regulation", "Glucagon type ligand receptors", "Gluconeogenesis", "Glucose metabolism", "Glucuronidation", "Glutamate and glutamine metabolism", "Glutamate neurotransmitter release cycle", "Glutathione conjugation", "Glutathione synthesis and recycling", "Glycerophospholipid biosynthesis", "Glycerophospholipid catabolism", "Glycogen breakdown glycogenolysis", "Glycogen metabolism", "Glycogen storage diseases", "Glycogen synthesis", "Glycolysis", "Glycosaminoglycan metabolism", "Glycosphingolipid metabolism", "Glyoxylate metabolism and glycine degradation", "Golgi associated vesicle biogenesis", "Golgi cisternae pericentriolar stack reorganization", "Golgi to er retrograde transport", "Gp1b ix v activation signalling", "Gpcr ligand binding", "Gpvi mediated activation cascade", "Grb2 events in erbb2 signaling", "Grb2 sos provides linkage to mapk signaling for integrins", "Growth hormone receptor signaling", "Hats acetylate histones", "Hcmv early events", "Hcmv infection", "Hcmv late events", "Hdacs deacetylate histones", "Hdl assembly", "Hdl clearance", "Hdms demethylate histones", "Hdr through homologous recombination hrr", "Hdr through mmej alt nhej", "Hdr through single strand annealing ssa", "Hedgehog ligand biogenesis", "Hedgehog off state", "Hedgehog on state", "Heme biosynthesis", "Heme degradation", "Heme signaling", "Hemostasis", "Heparan sulfate heparin hs gag metabolism", "Hiv elongation arrest and recovery", "Hiv infection", "Hiv life cycle", "Hiv transcription elongation", "Hiv transcription initiation", "Homologous dna pairing and strand exchange", "Homology directed repair", "Host interactions of hiv factors", "Hs gag biosynthesis", "Hs gag degradation", "Hsf1 activation", "Hsf1 dependent transactivation", "Hsp90 chaperone cycle for steroid hormone receptors shr in the presence of ligand", "Hur elavl1 binds and stabilizes mrna", "Hyaluronan metabolism", "Hyaluronan uptake and degradation", "Hydrolysis of lpc", "Ikba variant leads to eda id", "Ikk complex recruitment mediated by rip1", "Immunoregulatory interactions between a lymphoid and a non lymphoid cell", "Inactivation of cdc42 and rac1", "Inactivation of csf3 g csf signaling", "Incretin synthesis secretion and inactivation", "Infection with mycobacterium tuberculosis", "Infectious disease", "Inflammasomes", "Influenza infection", "Inhibition of dna recombination at telomere", "Inhibition of replication initiation of damaged dna by rb1 e2f1", "Inhibition of the proteolytic activity of apc c required for the onset of anaphase by mitotic spindle checkpoint components", "Initiation of nuclear envelope ne reformation", "Inla mediated entry of listeria monocytogenes into host cells", "Inlb mediated entry of listeria monocytogenes into host cell", "Innate immune system", "Inositol phosphate metabolism", "Insertion of tail anchored proteins into the endoplasmic reticulum membrane", "Insulin processing", "Insulin receptor recycling", "Insulin receptor signalling cascade", "Integration of energy metabolism", "Integration of provirus", "Integrin cell surface interactions", "Integrin signaling", "Interaction between l1 and ankyrins", "Interactions of rev with host cellular proteins", "Interactions of vpr with host cellular proteins", "Interconversion of nucleotide di and triphosphates", "Interferon alpha beta signaling", "Interferon gamma signaling", "Interferon signaling", "Interleukin 1 family signaling", "Interleukin 1 signaling", "Interleukin 10 signaling", "Interleukin 12 family signaling", "Interleukin 12 signaling", "Interleukin 15 signaling", "Interleukin 17 signaling", "Interleukin 2 family signaling", "Interleukin 20 family signaling", "Interleukin 21 signaling", "Interleukin 23 signaling", "Interleukin 27 signaling", "Interleukin 3 interleukin 5 and gm csf signaling", "Interleukin 35 signalling", "Interleukin 37 signaling", "Interleukin 4 and interleukin 13 signaling", "Interleukin 6 family signaling", "Interleukin 6 signaling", "Interleukin 7 signaling", "Interleukin 9 signaling", "Interleukin receptor shc signaling", "Intra golgi and retrograde golgi to er traffic", "Intra golgi traffic", "Intracellular signaling by second messengers", "Intraflagellar transport", "Intrinsic pathway for apoptosis", "Intrinsic pathway of fibrin clot formation", "Inwardly rectifying k channels", "Ion channel transport", "Ion homeostasis", "Ion transport by p type atpases", "Ionotropic activity of kainate receptors", "Irak1 recruits ikk complex", "Irak2 mediated activation of tak1 complex", "Irak4 deficiency tlr2 4", "Ire1alpha activates chaperones", "Irf3 mediated activation of type 1 ifn", "Irf3 mediated induction of type i ifn", "Iron uptake and transport", "Irs mediated signalling", "Jnk c jun kinases phosphorylation and activation mediated by activated human tak1", "Josephin domain dubs", "Keratan sulfate biosynthesis", "Keratan sulfate degradation", "Keratan sulfate keratin metabolism", "Keratinization", "Ketone body metabolism", "Killing mechanisms", "Kinesins", "Ksrp khsrp binds and destabilizes mrna", "L1cam interactions", "Lagging strand synthesis", "Laminin interactions", "Late endosomal microautophagy", "Ldl clearance", "Ldl remodeling", "Leishmania infection", "Linoleic acid la metabolism", "Lipophagy", "Listeria monocytogenes entry into host cells", "Long term potentiation", "Loss of function of mecp2 in rett syndrome", "Loss of mecp2 binding ability to the ncor smrt complex", "Lrr flii interacting protein 1 lrrfip1 activates type i ifn production", "Lysine catabolism", "Lysosome vesicle biogenesis", "M phase", "Map2k and mapk activation", "Map3k8 tpl2 dependent mapk1 3 activation", "Mapk family signaling cascades", "Mapk targets nuclear events mediated by map kinases", "Mapk1 erk2 activation", "Mapk3 erk1 activation", "Mapk6 mapk4 signaling", "Mastl facilitates mitotic progression", "Maturation of protein 3a", "Maturation of sars cov 1 spike protein", "Maturation of sars cov 2 nucleoprotein", "Maturation of sars cov 2 spike protein", "Mecp2 regulates neuronal receptors and channels", "Mecp2 regulates transcription factors", "Mecp2 regulates transcription of neuronal ligands", "Meiosis", "Meiotic recombination", "Meiotic synapsis", "Membrane trafficking", "Met activates pi3k akt signaling", "Met activates ptk2 signaling", "Met activates ptpn11", "Met activates rap1 and rac1", "Met activates ras signaling", "Met interacts with tns proteins", "Met promotes cell motility", "Met receptor activation", "Met receptor recycling", "Metabolic disorders of biological oxidation enzymes", "Metabolism of amino acids and derivatives", "Metabolism of angiotensinogen to angiotensins", "Metabolism of carbohydrates", "Metabolism of cofactors", "Metabolism of fat soluble vitamins", "Metabolism of folate and pterines", "Metabolism of ingested semet sec mesec into h2se", "Metabolism of lipids", "Metabolism of nitric oxide nos3 activation and regulation", "Metabolism of nucleotides", "Metabolism of polyamines", "Metabolism of porphyrins", "Metabolism of rna", "Metabolism of steroid hormones", "Metabolism of steroids", "Metabolism of vitamins and cofactors", "Metabolism of water soluble vitamins and cofactors", "Metal ion slc transporters", "Metalloprotease dubs", "Methionine salvage pathway", "Methylation", "Mhc class ii antigen presentation", "Microrna mirna biogenesis", "Miro gtpase cycle", "Miscellaneous transport and binding events", "Mismatch repair", "Mitochondrial biogenesis", "Mitochondrial calcium ion transport", "Mitochondrial fatty acid beta oxidation", "Mitochondrial fatty acid beta oxidation of saturated fatty acids", "Mitochondrial fatty acid beta oxidation of unsaturated fatty acids", "Mitochondrial iron sulfur cluster biogenesis", "Mitochondrial protein import", "Mitochondrial translation", "Mitochondrial trna aminoacylation", "Mitophagy", "Mitotic g1 phase and g1 s transition", "Mitotic g2 g2 m phases", "Mitotic metaphase and anaphase", "Mitotic prometaphase", "Mitotic prophase", "Mitotic spindle checkpoint", "Mitotic telophase cytokinesis", "Molecules associated with elastic fibres", "Molybdenum cofactor biosynthesis", "Mrna capping", "Mrna decay by 3 to 5 exoribonuclease", "Mrna decay by 5 to 3 exoribonuclease", "Mrna editing", "Mrna splicing", "Mrna splicing minor pathway", "Mtor signalling", "Mtorc1 mediated signalling", "Mucopolysaccharidoses", "Muscle contraction", "Myd88 independent tlr4 cascade", "Myoclonic epilepsy of lafora", "Myogenesis", "N glycan antennae elongation in the medial trans golgi", "N glycan trimming and elongation in the cis golgi", "N glycan trimming in the er and calnexin calreticulin cycle", "Na cl dependent neurotransmitter transporters", "Nade modulates death signalling", "Ncam signaling for neurite out growth", "Neddylation", "Nef and signal transduction", "Nef mediated cd4 down regulation", "Nef mediated cd8 down regulation", "Nef mediated downregulation of mhc class i complex cell surface expression", "Nef mediates down modulation of cell surface receptors by recruiting them to clathrin adapters", "Negative epigenetic regulation of rrna expression", "Negative feedback regulation of mapk pathway", "Negative regulation of fgfr1 signaling", "Negative regulation of fgfr2 signaling", "Negative regulation of fgfr3 signaling", "Negative regulation of fgfr4 signaling", "Negative regulation of flt3", "Negative regulation of mapk pathway", "Negative regulation of met activity", "Negative regulation of nmda receptor mediated neuronal transmission", "Negative regulation of notch4 signaling", "Negative regulation of the pi3k akt network", "Negative regulators of ddx58 ifih1 signaling", "Nephrin family interactions", "Nervous system development", "Netrin 1 signaling", "Netrin mediated repulsion signals", "Neurexins and neuroligins", "Neurofascin interactions", "Neuronal system", "Neurotoxicity of clostridium toxins", "Neurotransmitter clearance", "Neurotransmitter receptors and postsynaptic signal transmission", "Neurotransmitter release cycle", "Neutrophil degranulation", "Nf kb activation through fadd rip 1 pathway mediated by caspase 8 and 10", "Nf kb is activated and signals survival", "Ngf stimulated transcription", "Nicotinamide salvaging", "Nicotinate metabolism", "Nod1 2 signaling pathway", "Non integrin membrane ecm interactions", "Noncanonical activation of notch3", "Nonhomologous end joining nhej", "Nonsense mediated decay nmd", "Nostrin mediated enos trafficking", "Notch hlh transcription pathway", "Notch1 intracellular domain regulates transcription", "Notch2 activation and transmission of signal to the nucleus", "Notch3 activation and transmission of signal to the nucleus", "Notch3 intracellular domain regulates transcription", "Notch4 activation and transmission of signal to the nucleus", "Notch4 intracellular domain regulates transcription", "Nr1h2 and nr1h3 mediated signaling", "Nr1h2 nr1h3 regulate gene expression linked to lipogenesis", "Nr1h3 nr1h2 regulate gene expression linked to cholesterol transport and efflux", "Nrage signals death through jnk", "Nrcam interactions", "Nrif signals cell death from the nucleus", "Ns1 mediated effects on host pathways", "Ntrk2 activates rac1", "Nuclear envelope breakdown", "Nuclear envelope ne reassembly", "Nuclear events kinase and transcription factor activation", "Nuclear events stimulated by alk signaling in cancer", "Nuclear import of rev protein", "Nuclear pore complex npc disassembly", "Nuclear signaling by erbb4", "Nucleotide binding domain leucine rich repeat containing receptor nlr signaling pathways", "Nucleotide biosynthesis", "Nucleotide catabolism", "Nucleotide excision repair", "Nucleotide salvage", "O linked glycosylation", "O linked glycosylation of mucins", "Oas antiviral response", "Oncogene induced senescence", "Oncogenic mapk signaling", "Opioid signalling", "Orc1 removal from chromatin", "Organelle biogenesis and maintenance", "Organic anion transporters", "Other interleukin signaling", "Other semaphorin interactions", "Ovarian tumor domain proteases", "Oxidative stress induced senescence", "P130cas linkage to mapk signaling for integrins", "P38mapk events", "P75 ntr receptor mediated signalling", "P75ntr negatively regulates cell cycle via sc1", "P75ntr recruits signalling complexes", "P75ntr regulates axonogenesis", "P75ntr signals via nf kb", "Parasite infection", "Passive transport by aquaporins", "Pcna dependent long patch base excision repair", "Pcp ce pathway", "Pd 1 signaling", "Pecam1 interactions", "Pentose phosphate pathway", "Peptide hormone metabolism", "Peptide ligand binding receptors", "Perk regulates gene expression", "Peroxisomal lipid metabolism", "Peroxisomal protein import", "Pexophagy", "Phase 0 rapid depolarisation", "Phase i functionalization of compounds", "Phase ii conjugation of compounds", "Phenylalanine and tyrosine metabolism", "Phenylalanine metabolism", "Phosphate bond hydrolysis by nudt proteins", "Phospholipase c mediated cascade fgfr2", "Phospholipase c mediated cascade fgfr4", "Phospholipid metabolism", "Phosphorylation of emi1", "Phosphorylation of the apc c", "Pi 3k cascade fgfr1", "Pi 3k cascade fgfr2", "Pi 3k cascade fgfr3", "Pi 3k cascade fgfr4", "Pi metabolism", "Pi3k akt signaling in cancer", "Pi3k events in erbb2 signaling", "Pi5p regulates tp53 acetylation", "Pink1 prkn mediated mitophagy", "Piwi interacting rna pirna biogenesis", "Pka activation in glucagon signalling", "Pka mediated phosphorylation of creb", "Pka mediated phosphorylation of key metabolic factors", "Pkmts methylate histone lysines", "Plasma lipoprotein assembly", "Plasma lipoprotein assembly remodeling and clearance", "Plasma lipoprotein clearance", "Plasma lipoprotein remodeling", "Platelet activation signaling and aggregation", "Platelet adhesion to exposed collagen", "Platelet aggregation plug formation", "Platelet calcium homeostasis", "Platelet homeostasis", "Platelet sensitization by ldl", "Polb dependent long patch base excision repair", "Polo like kinase mediated events", "Polymerase switching", "Polymerase switching on the c strand of the telomere", "Positive epigenetic regulation of rrna expression", "Post chaperonin tubulin folding pathway", "Post translational modification synthesis of gpi anchored proteins", "Post translational protein modification", "Postmitotic nuclear pore complex npc reformation", "Potassium channels", "Potential therapeutics for sars", "Pou5f1 oct4 sox2 nanog activate genes related to proliferation", "Pp2a mediated dephosphorylation of key metabolic factors", "Prc2 methylates histones and dna", "Pre notch expression and processing", "Pre notch processing in golgi", "Pre notch processing in the endoplasmic reticulum", "Pregnenolone biosynthesis", "Presynaptic function of kainate receptors", "Prevention of phagosomal lysosomal fusion", "Processing and activation of sumo", "Processing of capped intron containing pre mrna", "Processing of capped intronless pre mrna", "Processing of dna double strand break ends", "Processing of intronless pre mrnas", "Processing of smdt1", "Processive synthesis on the c strand of the telomere", "Processive synthesis on the lagging strand", "Programmed cell death", "Prolactin receptor signaling", "Prolonged erk activation events", "Propionyl coa catabolism", "Prostacyclin signalling through prostacyclin receptor", "Protein folding", "Protein localization", "Protein methylation", "Protein protein interactions at synapses", "Protein repair", "Protein ubiquitination", "Proton coupled monocarboxylate transport", "Pten regulation", "Ptk6 expression", "Ptk6 regulates cell cycle", "Ptk6 regulates proteins involved in rna processing", "Ptk6 regulates rho gtpases ras gtpase and map kinases", "Purine catabolism", "Purine ribonucleoside monophosphate biosynthesis", "Purine salvage", "Purinergic signaling in leishmaniasis infection", "Pyrimidine salvage", "Pyroptosis", "Pyruvate metabolism", "Pyruvate metabolism and citric acid tca cycle", "Ra biosynthesis pathway", "Rab gefs exchange gtp for gdp on rabs", "Rab geranylgeranylation", "Rab regulation of trafficking", "Rac1 gtpase cycle", "Rac2 gtpase cycle", "Rac3 gtpase cycle", "Raf activation", "Raf independent mapk1 3 activation", "Rap1 signalling", "Ras activation upon ca2 influx through nmda receptor", "Ras processing", "Reactions specific to the complex n glycan synthesis pathway", "Receptor mediated mitophagy", "Receptor type tyrosine protein phosphatases", "Recognition and association of dna glycosylase with site containing an affected purine", "Recognition of dna damage by pcna containing replication complex", "Recruitment of mitotic centrosome proteins and complexes", "Recruitment of numa to mitotic centrosomes", "Recycling of eif2 gdp", "Recycling pathway of l1", "Reduction of cytosolic ca levels", "Regulated necrosis", "Regulated proteolysis of p75ntr", "Regulation by c flip", "Regulation of bach1 activity", "Regulation of beta cell development", "Regulation of cholesterol biosynthesis by srebp srebf", "Regulation of commissural axon pathfinding by slit and robo", "Regulation of cytoskeletal remodeling and cell spreading by ipp complex components", "Regulation of expression of slits and robos", "Regulation of foxo transcriptional activity by acetylation", "Regulation of gene expression in beta cells", "Regulation of gene expression in late stage branching morphogenesis pancreatic bud precursor cells", "Regulation of glucokinase by glucokinase regulatory protein", "Regulation of glycolysis by fructose 2 6 bisphosphate metabolism", "Regulation of hmox1 expression and activity", "Regulation of hsf1 mediated heat shock response", "Regulation of ifna signaling", "Regulation of ifng signaling", "Regulation of innate immune responses to cytosolic dna", "Regulation of insulin like growth factor igf transport and uptake by insulin like growth factor binding proteins igfbps", "Regulation of insulin secretion", "Regulation of kit signaling", "Regulation of lipid metabolism by pparalpha", "Regulation of localization of foxo transcription factors", "Regulation of mecp2 expression and activity", "Regulation of mrna stability by proteins that bind au rich elements", "Regulation of plk1 activity at g2 m transition", "Regulation of pten gene transcription", "Regulation of pten localization", "Regulation of pten mrna translation", "Regulation of pten stability and activity", "Regulation of pyruvate dehydrogenase pdh complex", "Regulation of ras by gaps", "Regulation of runx1 expression and activity", "Regulation of runx2 expression and activity", "Regulation of runx3 expression and activity", "Regulation of signaling by cbl", "Regulation of tlr by endogenous ligand", "Regulation of tnfr1 signaling", "Regulation of tp53 activity", "Regulation of tp53 activity through acetylation", "Regulation of tp53 activity through association with co factors", "Regulation of tp53 activity through methylation", "Regulation of tp53 activity through phosphorylation", "Regulation of tp53 expression and degradation", "Release of apoptotic factors from the mitochondria", "Repression of wnt target genes", "Reproduction", "Resolution of abasic sites ap sites", "Resolution of ap sites via the multiple nucleotide patch replacement pathway", "Resolution of d loop structures", "Resolution of d loop structures through synthesis dependent strand annealing sdsa", "Resolution of sister chromatid cohesion", "Respiratory electron transport", "Respiratory electron transport atp synthesis by chemiosmotic coupling and heat production by uncoupling proteins", "Response of eif2ak1 hri to heme deficiency", "Response of eif2ak4 gcn2 to amino acid deficiency", "Response of mtb to phagocytosis", "Response to elevated platelet cytosolic ca2", "Ret signaling", "Retinoid cycle disease events", "Retrograde neurotrophin signalling", "Retrograde transport at the trans golgi network", "Rho gtpase cycle", "Rho gtpase effectors", "Rho gtpases activate cit", "Rho gtpases activate formins", "Rho gtpases activate iqgaps", "Rho gtpases activate ktn1", "Rho gtpases activate nadph oxidases", "Rho gtpases activate paks", "Rho gtpases activate pkns", "Rho gtpases activate rocks", "Rho gtpases activate wasps and waves", "Rhoa gtpase cycle", "Rhob gtpase cycle", "Rhobtb gtpase cycle", "Rhobtb1 gtpase cycle", "Rhobtb2 gtpase cycle", "Rhobtb3 atpase cycle", "Rhoc gtpase cycle", "Rhod gtpase cycle", "Rhof gtpase cycle", "Rhog gtpase cycle", "Rhoh gtpase cycle", "Rhoj gtpase cycle", "Rhoq gtpase cycle", "Rhot1 gtpase cycle", "Rhou gtpase cycle", "Rhov gtpase cycle", "Rip mediated nfkb activation via zbp1", "Ripk1 mediated regulated necrosis", "Rmts methylate histone arginines", "Rna polymerase i promoter escape", "Rna polymerase i transcription", "Rna polymerase i transcription initiation", "Rna polymerase i transcription termination", "Rna polymerase ii transcribes snrna genes", "Rna polymerase ii transcription", "Rna polymerase ii transcription termination", "Rna polymerase iii chain elongation", "Rna polymerase iii transcription", "Rna polymerase iii transcription initiation from type 1 promoter", "Rna polymerase iii transcription initiation from type 3 promoter", "Rna polymerase iii transcription termination", "Rnd1 gtpase cycle", "Rnd2 gtpase cycle", "Rnd3 gtpase cycle", "Robo receptors bind akap5", "Role of abl in robo slit signaling", "Role of lat2 ntal lab on calcium mobilization", "Role of phospholipids in phagocytosis", "Role of second messengers in netrin 1 signaling", "Rora activates gene expression", "Ros and rns production in phagocytes", "Rrna modification in the mitochondrion", "Rrna modification in the nucleus and cytosol", "Rrna processing", "Rrna processing in the mitochondrion", "Rsk activation", "Runx1 interacts with co factors whose precise effect on runx1 targets is not known", "Runx1 regulates estrogen receptor mediated transcription", "Runx1 regulates expression of components of tight junctions", "Runx1 regulates genes involved in megakaryocyte differentiation and platelet function", "Runx1 regulates transcription of genes involved in differentiation of hscs", "Runx1 regulates transcription of genes involved in differentiation of myeloid cells", "Runx2 regulates bone development", "Runx2 regulates genes involved in cell migration", "Runx2 regulates osteoblast differentiation", "Runx3 regulates cdkn1a transcription", "Runx3 regulates notch signaling", "Runx3 regulates p14 arf", "Runx3 regulates wnt signaling", "S phase", "Sars cov 1 infection", "Sars cov 2 infection", "Sars cov infections", "Scavenging by class a receptors", "Scavenging by class b receptors", "Scavenging by class f receptors", "Scavenging of heme from plasma", "Scf skp2 mediated degradation of p27 p21", "Sealing of the nuclear envelope ne by escrt iii", "Selective autophagy", "Selenoamino acid metabolism", "Sema3a pak dependent axon repulsion", "Sema3a plexin repulsion signaling by inhibiting integrin adhesion", "Sema4d in semaphorin signaling", "Sema4d induced cell migration and growth cone collapse", "Sema4d mediated inhibition of cell attachment and migration", "Semaphorin interactions", "Senescence associated secretory phenotype sasp", "Sensing of dna double strand breaks", "Sensory perception", "Sensory processing of sound", "Sensory processing of sound by outer hair cells of the cochlea", "Separation of sister chromatids", "Serine biosynthesis", "Shc mediated cascade fgfr1", "Shc mediated cascade fgfr3", "Shc mediated cascade fgfr4", "Shc related events triggered by igf1r", "Shc1 events in egfr signaling", "Shc1 events in erbb2 signaling", "Shc1 events in erbb4 signaling", "Sialic acid metabolism", "Signal amplification", "Signal attenuation", "Signal regulatory protein family interactions", "Signal transduction by l1", "Signaling by activin", "Signaling by alk", "Signaling by alk in cancer", "Signaling by bmp", "Signaling by braf and raf1 fusions", "Signaling by csf3 g csf", "Signaling by ctnnb1 phospho site mutants", "Signaling by cytosolic fgfr1 fusion mutants", "Signaling by egfr", "Signaling by egfr in cancer", "Signaling by erbb2", "Signaling by erbb2 ecd mutants", "Signaling by erbb2 in cancer", "Signaling by erbb4", "Signaling by erythropoietin", "Signaling by fgfr", "Signaling by fgfr in disease", "Signaling by fgfr1", "Signaling by fgfr1 in disease", "Signaling by fgfr2", "Signaling by fgfr2 iiia tm", "Signaling by fgfr2 in disease", "Signaling by fgfr3", "Signaling by fgfr3 fusions in cancer", "Signaling by fgfr4", "Signaling by fgfr4 in disease", "Signaling by flt3 fusion proteins", "Signaling by flt3 itd and tkd mutants", "Signaling by gpcr", "Signaling by hedgehog", "Signaling by hippo", "Signaling by insulin receptor", "Signaling by interleukins", "Signaling by kit in disease", "Signaling by leptin", "Signaling by mapk mutants", "Signaling by met", "Signaling by moderate kinase activity braf mutants", "Signaling by mras complex mutants", "Signaling by mst1", "Signaling by nodal", "Signaling by notch", "Signaling by notch1", "Signaling by notch1 pest domain mutants in cancer", "Signaling by notch2", "Signaling by notch3", "Signaling by notch4", "Signaling by ntrk2 trkb", "Signaling by ntrk3 trkc", "Signaling by ntrks", "Signaling by nuclear receptors", "Signaling by pdgf", "Signaling by pdgfr in disease", "Signaling by pdgfra transmembrane juxtamembrane and kinase domain mutants", "Signaling by ptk6", "Signaling by receptor tyrosine kinases", "Signaling by retinoic acid", "Signaling by rho gtpases miro gtpases and rhobtb3", "Signaling by robo receptors", "Signaling by scf kit", "Signaling by tgf beta receptor complex", "Signaling by tgf beta receptor complex in cancer", "Signaling by tgfb family members", "Signaling by the b cell receptor bcr", "Signaling by type 1 insulin like growth factor 1 receptor igf1r", "Signaling by vegf", "Signaling by wnt", "Signaling by wnt in cancer", "Signalling to erks", "Signalling to ras", "Sirt1 negatively regulates rrna expression", "Slbp dependent processing of replication dependent histone pre mrnas", "Slc mediated transmembrane transport", "Slc transporter disorders", "Smac xiap regulated apoptotic response", "Smad2 smad3 smad4 heterotrimer regulates transcription", "Small interfering rna sirna biogenesis", "Smooth muscle contraction", "Snrnp assembly", "Sodium calcium exchangers", "Sos mediated signalling", "Sphingolipid de novo biosynthesis", "Sphingolipid metabolism", "Spry regulation of fgf signaling", "Srp dependent cotranslational protein targeting to membrane", "Stabilization of p53", "Stat3 nuclear events downstream of alk signaling", "Stat5 activation", "Stat5 activation downstream of flt3 itd mutants", "Stimuli sensing channels", "Sting mediated induction of host immune responses", "Striated muscle contraction", "Sulfide oxidation to sulfate", "Sulfur amino acid metabolism", "Sumo is conjugated to e1 uba2 sae1", "Sumo is transferred from e1 to e2 ube2i ubc9", "Sumoylation", "Sumoylation of chromatin organization proteins", "Sumoylation of dna damage response and repair proteins", "Sumoylation of dna methylation proteins", "Sumoylation of dna replication proteins", "Sumoylation of immune response proteins", "Sumoylation of rna binding proteins", "Sumoylation of sumoylation proteins", "Sumoylation of transcription cofactors", "Sumoylation of transcription factors", "Sumoylation of ubiquitinylation proteins", "Suppression of apoptosis", "Suppression of phagosomal maturation", "Surfactant metabolism", "Switching of origins to a post replicative state", "Synaptic adhesion like molecules", "Syndecan interactions", "Synthesis of 5 eicosatetraenoic acids", "Synthesis of active ubiquitin roles of e1 and e2 enzymes", "Synthesis of bile acids and bile salts", "Synthesis of bile acids and bile salts via 7alpha hydroxycholesterol", "Synthesis of diphthamide eef2", "Synthesis of dna", "Synthesis of dolichyl phosphate", "Synthesis of epoxy eet and dihydroxyeicosatrienoic acids dhet", "Synthesis of gdp mannose", "Synthesis of ip2 ip and ins in the cytosol", "Synthesis of ip3 and ip4 in the cytosol", "Synthesis of ketone bodies", "Synthesis of leukotrienes lt and eoxins ex", "Synthesis of lipoxins lx", "Synthesis of pa", "Synthesis of pc", "Synthesis of pe", "Synthesis of pg", "Synthesis of pi", "Synthesis of pips at the early endosome membrane", "Synthesis of pips at the er membrane", "Synthesis of pips at the golgi membrane", "Synthesis of pips at the late endosome membrane", "Synthesis of pips at the plasma membrane", "Synthesis of prostaglandins pg and thromboxanes tx", "Synthesis of pyrophosphates in the cytosol", "Synthesis of substrates in n glycan biosythesis", "Synthesis of udp n acetyl glucosamine", "Synthesis of very long chain fatty acyl coas", "Synthesis secretion and deacylation of ghrelin", "Synthesis secretion and inactivation of glucagon like peptide 1 glp 1", "Synthesis secretion and inactivation of glucose dependent insulinotropic polypeptide gip", "Tak1 activates nfkb by phosphorylation and activation of ikks complex", "Tbc rabgaps", "Tcf dependent signaling in response to wnt", "Tcr signaling", "Telomere c strand lagging strand synthesis", "Telomere c strand synthesis initiation", "Telomere extension by telomerase", "Telomere maintenance", "Terminal pathway of complement", "Termination of translesion dna synthesis", "Tetrahydrobiopterin bh4 synthesis recycling salvage and regulation", "Tfap2 ap 2 family regulates transcription of growth factors and their receptors", "Tfap2a acts as a transcriptional repressor during retinoic acid induced cell differentiation", "Tgf beta receptor signaling activates smads", "Tgf beta receptor signaling in emt epithelial to mesenchymal transition", "The activation of arylsulfatases", "The canonical retinoid cycle in rods twilight vision", "The citric acid tca cycle and respiratory electron transport", "The nlrp3 inflammasome", "The phototransduction cascade", "The role of gtse1 in g2 m progression after g2 checkpoint", "The role of nef in hiv 1 replication and disease pathogenesis", "Thrombin signalling through proteinase activated receptors pars", "Thromboxane signalling through tp receptor", "Ticam1 rip1 mediated ikk complex recruitment", "Ticam1 traf6 dependent induction of tak1 complex", "Tie2 signaling", "Tight junction interactions", "Tnf receptor superfamily tnfsf members mediating non canonical nf kb pathway", "Tnf signaling", "Tnfr1 induced nfkappab signaling pathway", "Tnfr1 induced proapoptotic signaling", "Tnfr1 mediated ceramide production", "Tnfr2 non canonical nf kb pathway", "Toll like receptor 9 tlr9 cascade", "Toll like receptor cascades", "Toll like receptor tlr1 tlr2 cascade", "Toxicity of botulinum toxin type d botd", "Tp53 regulates metabolic genes", "Tp53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "Tp53 regulates transcription of caspase activators and caspases", "Tp53 regulates transcription of cell cycle genes", "Tp53 regulates transcription of cell death genes", "Tp53 regulates transcription of death receptors and ligands", "Tp53 regulates transcription of dna repair genes", "Tp53 regulates transcription of genes involved in cytochrome c release", "Tp53 regulates transcription of genes involved in g1 cell cycle arrest", "Tp53 regulates transcription of genes involved in g2 cell cycle arrest", "Tp53 regulates transcription of several additional cell death genes whose specific roles in p53 dependent apoptosis remain uncertain", "Traf3 dependent irf activation pathway", "Traf6 mediated induction of tak1 complex within tlr4 complex", "Traf6 mediated irf7 activation", "Traf6 mediated irf7 activation in tlr7 8 or 9 signaling", "Traf6 mediated nf kb activation", "Trafficking and processing of endosomal tlr", "Trafficking of ampa receptors", "Trafficking of glur2 containing ampa receptors", "Trafficking of myristoylated proteins to the cilium", "Trans golgi network vesicle budding", "Transcription coupled nucleotide excision repair tc ner", "Transcription of e2f targets under negative control by dream complex", "Transcription of e2f targets under negative control by p107 rbl1 and p130 rbl2 in complex with hdac1", "Transcription of the hiv genome", "Transcriptional activation of mitochondrial biogenesis", "Transcriptional activity of smad2 smad3 smad4 heterotrimer", "Transcriptional regulation by e2f6", "Transcriptional regulation by mecp2", "Transcriptional regulation by runx1", "Transcriptional regulation by runx2", "Transcriptional regulation by runx3", "Transcriptional regulation by small rnas", "Transcriptional regulation by the ap 2 tfap2 family of transcription factors", "Transcriptional regulation by tp53", "Transcriptional regulation by ventx", "Transcriptional regulation of granulopoiesis", "Transcriptional regulation of pluripotent stem cells", "Transcriptional regulation of white adipocyte differentiation", "Transferrin endocytosis and recycling", "Translation", "Translation of replicase and assembly of the replication transcription complex", "Translation of sars cov 1 structural proteins", "Translation of sars cov 2 structural proteins", "Translesion synthesis by polh", "Translesion synthesis by polk", "Translesion synthesis by y family dna polymerases bypasses lesions on dna template", "Translocation of slc2a4 glut4 to the plasma membrane", "Transmission across chemical synapses", "Transport and synthesis of paps", "Transport of bile salts and organic acids metal ions and amine compounds", "Transport of connexons to the plasma membrane", "Transport of fatty acids", "Transport of inorganic cations anions and amino acids oligopeptides", "Transport of mature mrnas derived from intronless transcripts", "Transport of mature transcript to cytoplasm", "Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane", "Transport of nucleotide sugars", "Transport of small molecules", "Transport of the slbp dependant mature mrna", "Transport of vitamins nucleosides and related molecules", "Transport to the golgi and subsequent modification", "Triglyceride biosynthesis", "Triglyceride catabolism", "Triglyceride metabolism", "Tristetraprolin ttp zfp36 binds and destabilizes mrna", "Trna aminoacylation", "Trna modification in the mitochondrion", "Trna modification in the nucleus and cytosol", "Trna processing", "Trna processing in the mitochondrion", "Trna processing in the nucleus", "Tryptophan catabolism", "Type i hemidesmosome assembly", "Tyrosine catabolism", "Tysnd1 cleaves peroxisomal proteins", "Ub specific processing proteases", "Ubiquinol biosynthesis", "Uch proteinases", "Unblocking of nmda receptors glutamate binding and activation", "Unfolded protein response upr", "Unwinding of dna", "Uptake and actions of bacterial toxins", "Uptake and function of anthrax toxins", "Uptake and function of diphtheria toxin", "Urea cycle", "Vasopressin regulates renal water homeostasis via aquaporins", "Vegfr2 mediated cell proliferation", "Vegfr2 mediated vascular permeability", "Vesicle mediated transport", "Viral messenger rna synthesis", "Visual phototransduction", "Vitamin b1 thiamin metabolism", "Vitamin b2 riboflavin metabolism", "Vitamin b5 pantothenate metabolism", "Vitamin c ascorbate metabolism", "Vitamin d calciferol metabolism", "Vldl assembly", "Vldlr internalisation and degradation", "Vxpx cargo targeting to cilium", "Wax and plasmalogen biosynthesis", "Wnt ligand biogenesis and trafficking", "Wnt mediated activation of dvl", "Wnt5a dependent internalization of fzd2 fzd5 and ror2", "Wnt5a dependent internalization of fzd4", "Zbp1 dai mediated induction of type i ifns", "Zinc efflux and compartmentalization by the slc30 family", "Zinc influx into cells by the slc39 gene family", "Zinc transporters"], "available_proteins": ["AAAS", "AAMP", "AARS", "AARS2", "AASDHPPT", "AASS", "AATF", "ABCB1", "ABCB7", "ABCC1", "ABCD3", "ABCE1", "ABCF1", "ABHD10", "ABHD12", "ABHD14B", "ABHD6", "ABI1", "ACAA2", "ACACA", "ACACB", "ACAD11", "ACAD9", "ACADM", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACBD5", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT9", "ACOX1", "ACOX3", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN4", "ACTR10", "ACTR1A", "ACTR1B", "ACTR2", "ACTR3", "ADAR", "ADD1", "ADD3", "ADH5", "ADI1", "ADPGK", "ADPRHL2", "ADRM1", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGK", "AGL", "AGPAT1", "AGPAT5", "AGPS", "AHCY", "AHCYL1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AKAP12", "AKAP13", "AKR1A1", "AKR1B1", "AKR7A2", "AKT2", "ALDH18A1", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALG1", "ALG11", "ALG12", "ALKBH5", "ALYREF", "AMOT", "ANAPC1", "ANAPC16", "ANAPC2", "ANAPC5", "ANAPC7", "ANKFY1", "ANKLE2", "ANO10", "ANO6", "ANXA1", "ANXA2", "ANXA6", "AP1B1", "AP1G1", "AP1M1", "AP1S2", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3M1", "AP3S1", "APEH", "APEX1", "APLP2", "APOO", "APOOL", "APP", "APRT", "AQR", "ARAF", "ARCN1", "ARF4", "ARF6", "ARFGAP1", "ARFGAP2", "ARFIP2", "ARHGAP1", "ARHGAP17", "ARHGDIA", "ARHGEF1", "ARHGEF2", "ARID1A", "ARIH1", "ARIH2", "ARL1", "ARL2", "ARL3", "ARL6IP5", "ARMC8", "ARMCX3", "ARPC1A", "ARPC2", "ARPC3", "ARPC4", "ARPC5", "ASAH1", "ASCC2", "ASCC3", "ASNA1", "ASNS", "ASPH", "ATAD1", "ATAD2", "ATAD3B", "ATG3", "ATG4B", "ATG7", "ATG9A", "ATIC", "ATP13A1", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6", "ATP6AP1", "ATP6AP2", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1D", "ATP6V1E1", "ATP6V1H", "ATP7B", "ATRIP", "AURKA", "AURKB", "B3GALT6", "B4GAT1", "BABAM1", "BAG2", "BAG4", "BAG5", "BAG6", "BAIAP2", "BAK1", "BANF1", "BANP", "BASP1", "BAZ1B", "BCAP31", "BCAS2", "BCS1L", "BICD2", "BIRC6", "BLMH", "BLVRA", "BMS1", "BNIP1", "BOLA2*", "BOP1", "BPHL", "BPNT1", "BRAP", "BRD2", "BSG", "BUB1B", "BUB3", "BUD23", "BUD31", "BYSL", "C19orf70", "C1QBP", "C1orf35", "C2CD5", "CAB39", "CAD", "CALD1", "CALR", "CALU", "CAMK1", "CAMK2G", "CAND1", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPZA1", "CAPZA2", "CAPZB", "CARM1", "CARS", "CARS2", "CASK", "CAST", "CBR1", "CBX1", "CBX3", "CBX5", "CBX8", "CCAR1", "CCAR2", "CCDC22", "CCNB1", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2AP", "CD2BP2", "CD320", "CD47", "CDC16", "CDC20", "CDC23", "CDC27", "CDC34", "CDC37", "CDC40", "CDC42", "CDC5L", "CDC7", "CDC73", "CDCA8", "CDH2", "CDIPT", "CDK1", "CDK2", "CDK4", "CDK5", "CDK6", "CDKAL1", "CDKN2A", "CDS2", "CENPI", "CENPP", "CEP290", "CERS1", "CERS2", "CETN2", "CFL1", "CHAC2", "CHAF1B", "CHAMP1", "CHCHD3", "CHD1", "CHD1L", "CHD4", "CHERP", "CHID1", "CHKA", "CHMP1A", "CHMP2A", "CHMP2B", "CHMP3", "CHMP4B", "CHMP5", "CHMP7", "CHORDC1", "CHST14", "CHTF18", "CIAPIN1", "CKAP4", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLCN3", "CLCN7", "CLINT1", "CLNS1A", "CLTA", "CLTC", "CLU", "CMAS", "CMPK1", "CNDP2", "CNOT1", "CNOT10", "CNOT11", "CNOT2", "CNOT9", "COASY", "COG3", "COG4", "COLEC12", "COLGALT1", "COMMD1", "COMT", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS7A", "COPS8", "COPZ1", "COQ9", "COTL1", "COX18", "COX2", "COX4I1", "COX5A", "COX5B", "COX6C", "CPD", "CPNE1", "CPNE3", "CPOX", "CPSF1", "CPSF2", "CPSF3", "CPSF6", "CPSF7", "CPT1A", "CPT2", "CRK", "CRKL", "CRNKL1", "CROT", "CRTAP", "CS", "CSK", "CSNK1A1", "CSNK2A2", "CSNK2B", "CSTB", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTCF", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTPS2", "CTR9", "CTSA", "CTSB", "CTSC", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CWC15", "CWC27", "CYB5B", "CYB5R1", "CYB5R3", "CYC1", "CYFIP1", "CYFIP2", "CYP51A1", "DAD1", "DAG1", "DAP3", "DARS", "DARS2", "DAXX", "DBN1", "DBNL", "DBT", "DCAF13", "DCAF16", "DCAF7", "DCD", "DCP1B", "DCPS", "DCTD", "DCTN1", "DCTN2", "DCTN3", "DCTN4", "DCTPP1", "DCUN1D1", "DCUN1D5", "DCXR", "DDAH2", "DDB1", "DDOST", "DDRGK1", "DDX1", "DDX17", "DDX20", "DDX21", "DDX23", "DDX39A", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX52", "DDX56", "DDX6", "DEGS1", "DEK", "DERL1", "DERL2", "DFFA", "DGKE", "DHCR24", "DHCR7", "DHFR", "DHPS", "DHRS4", "DHRS7B", "DHX15", "DHX16", "DHX36", "DHX37", "DHX38", "DHX9", "DIABLO", "DIAPH1", "DIAPH2", "DIAPH3", "DIDO1", "DIMT1", "DIS3", "DKC1", "DLAT", "DLD", "DLG3", "DLGAP5", "DLST", "DNAJA1", "DNAJA2", "DNAJB1", "DNAJC11", "DNAJC13", "DNAJC19", "DNAJC2", "DNAJC3", "DNAJC7", "DNAJC8", "DNM1L", "DNM2", "DNMT1", "DNPH1", "DOCK7", "DOHH", "DOLPP1", "DPAGT1", "DPH2", "DPH5", "DPM1", "DPYSL2", "DPYSL5", "DSC3", "DSG2", "DSP", "DST", "DTYMK", "DUSP3", "DUSP9", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNC1LI2", "DYNLL2", "EARS2", "EBNA1BP2", "ECE1", "ECH1", "ECHS1", "ECI1", "ECI2", "ECSIT", "EDC3", "EDC4", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EFTUD2", "EHD1", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B5", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAC2", "ELAVL1", "ELMO2", "ELOA", "ELOB", "ELOC", "ELP1", "ELP2", "ELP3", "EMD", "EMG1", "EML4", "ENAH", "ENDOD1", "ENO1", "ENO2", "ENOPH1", "EPB41", "EPB41L2", "EPB41L3", "EPB41L5", "EPHA7", "EPHX1", "EPHX2", "EPRS", "EPS15L1", "ERAL1", "ERAP1", "ERCC2", "ERCC3", "ERCC6L", "ERLIN1", "ERLIN2", "ERO1A", "ERP44", "ESD", "ESPL1", "ESYT1", "ESYT2", "ETF1", "ETFA", "ETFB", "ETFDH", "ETNK1", "EXO1", "EXOC2", "EXOC3", "EXOC5", "EXOC6", "EXOC7", "EXOC8", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC9", "EZR", "F11R", "FABP5", "FADS2", "FAF2", "FAH", "FAHD1", "FAM114A2", "FAM3C", "FAM49B", "FAM98B", "FANCD2", "FANCI", "FAR1", "FARP1", "FARS2", "FARSA", "FARSB", "FASN", "FAU", "FBL", "FBXO21", "FBXO22", "FDFT1", "FDPS", "FDXR", "FECH", "FEN1", "FERMT2", "FGFR1OP", "FH", "FIP1L1", "FIS1", "FKBP14", "FKBP1A", "FKBP4", "FKBP5", "FKBP8", "FKBP9", "FLAD1", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FN3KRP", "FNTA", "FNTB", "FSCN1", "FTL", "FTO", "FTSJ3", "FUCA1", "FUCA2", "FUS", "FXR1", "G6PD", "GAA", "GABARAPL2", "GADD45GIP1", "GAK", "GAL", "GALK1", "GALNT1", "GALNT2", "GALNT4", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GATAD2B", "GBA", "GBE1", "GBF1", "GCAT", "GCC2", "GCDH", "GCLC", "GCN1", "GDAP1", "GDI1", "GDI2", "GDPD1", "GEMIN4", "GEMIN5", "GET4", "GFM1", "GFPT1", "GGCT", "GGCX", "GGH", "GGPS1", "GHDC", "GINS2", "GINS3", "GINS4", "GLA", "GLB1", "GLDC", "GLG1", "GLMN", "GLO1", "GLRX3", "GLS", "GLUD1", "GM2A", "GMPPB", "GMPS", "GNA13", "GNAI2", "GNAI3", "GNG12", "GNL3", "GNPAT", "GNPDA1", "GNS", "GOLGA2", "GOLGA3", "GOLGA5", "GOLGB1", "GOLIM4", "GOLM1", "GOPC", "GORASP2", "GOSR1", "GOT1", "GOT2", "GPAA1", "GPAM", "GPAT4", "GPD2", "GPHN", "GPI", "GPKOW", "GPS1", "GPT2", "GRB2", "GRHPR", "GRPEL1", "GRSF1", "GSPT1", "GSR", "GSS", "GSTK1", "GSTM3", "GSTO1", "GTF2B", "GTF2E1", "GTF2F1", "GTF3C1", "GTF3C2", "GTF3C3", "GTPBP3", "GYG1", "GYS1", "H1F0", "H2AFX", "H4C1*", "HACD2", "HACD3", "HACL1", "HADH", "HADHA", "HADHB", "HAT1", "HAUS1", "HAUS3", "HAUS4", "HAUS5", "HBS1L", "HCFC1", "HDAC1", "HDAC2", "HDGF", "HDLBP", "HEATR1", "HEBP1", "HEBP2", "HECTD1", "HEXA", "HEXB", "HGS", "HIBADH", "HIBCH", "HIKESHI", "HINT2", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLTF", "HM13", "HMBS", "HMGA1", "HMGB1", "HMGB2", "HMGCL", "HMGCR", "HMGCS1", "HMMR", "HMOX1", "HMOX2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPK", "HNRNPL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HPRT1", "HS2ST1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA13", "HSPA14", "HSPA1B", "HSPA2", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPB1", "HSPD1", "HSPE1", "HSPH1", "HUS1", "HUWE1", "HYOU1", "IARS", "IARS2", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDI1", "IFT27", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IKBKG", "ILF2", "ILK", "IMMT", "IMP3", "IMP4", "IMPA1", "IMPAD1", "IMPDH1", "IMPDH2", "INCENP", "INTS11", "INTS14", "INTS3", "INTS7", "IPO5", "IPO8", "IPO9", "IQGAP1", "IQGAP2", "IRS4", "IST1", "ITCH", "ITGB1", "ITM2C", "ITPA", "IVD", "JUP", "KARS", "KAT7", "KDELR1", "KDM1A", "KDM1B", "KDM2A", "KDM3B", "KDSR", "KHDRBS1", "KHSRP", "KIAA0391", "KIF11", "KIF14", "KIF15", "KIF18B", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF4A", "KIF5B", "KIFC1", "KIN", "KLC1", "KLC2", "KLC4", "KMT2A", "KNTC1", "KPNA1", "KPNA2", "KPNA3", "KPNA6", "KPNB1", "KRR1", "KTN1", "L2HGDH", "LAMP1", "LAMP2", "LAMTOR1", "LARS", "LARS2", "LAS1L", "LBR", "LDHA", "LDHB", "LEMD2", "LEMD3", "LETM1", "LGALS3BP", "LGMN", "LIG1", "LIG3", "LIPA", "LMAN2", "LMF2", "LMNA", "LMNB1", "LNPEP", "LPCAT1", "LPCAT3", "LPGAT1", "LRP1", "LRPPRC", "LRRC1", "LSM2", "LSM3", "LSM4", "LSM6", "LSM7", "LSS", "LTA4H", "LTV1", "LYPLA1", "LZTFL1", "M6PR", "MAD2L1", "MAGED2", "MAGT1", "MAIP1", "MAN1A1", "MAN2A1", "MAN2B1", "MANF", "MAP2K2", "MAPK1", "MAPK14", "MAPRE1", "MARC1", "MARS", "MASTL", "MAT2A", "MAT2B", "MAU2", "MAVS", "MBD3", "MBOAT7", "MCAT", "MCCC1", "MCCC2", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCU", "MDC1", "MDH1", "MDH2", "ME1", "ME2", "MECP2", "MED21", "MED23", "MED24", "MED25", "METAP2", "METTL14", "METTL3", "METTL7A", "MFN1", "MFN2", "MGST2", "MGST3", "MIA2", "MIA3", "MICU1", "MICU2", "MIF", "MIPEP", "MLEC", "MMAB", "MMS19", "MOGS", "MORF4L1", "MOSPD2", "MOV10", "MPC2", "MPDU1", "MPG", "MPHOSPH10", "MPI", "MPP1", "MPRIP", "MPST", "MPV17", "MRC2", "MRE11", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL14", "MRPL15", "MRPL17", "MRPL19", "MRPL21", "MRPL22", "MRPL23", "MRPL24", "MRPL28", "MRPL3", "MRPL37", "MRPL38", "MRPL39", "MRPL40", "MRPL44", "MRPL45", "MRPL46", "MRPL50", "MRPL53", "MRPL55", "MRPL58", "MRPL9", "MRPS11", "MRPS15", "MRPS16", "MRPS18A", "MRPS22", "MRPS23", "MRPS25", "MRPS27", "MRPS30", "MRPS31", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRPS9", "MRRF", "MSH2", "MSH3", "MSH6", "MSI2", "MSMO1", "MSN", "MTA1", "MTA2", "MTAP", "MTCH1", "MTHFD1", "MTHFD1L", "MTHFD2", "MTMR14", "MTMR2", "MTOR", "MTR", "MTX1", "MTX2", "MUT", "MVK", "MYBBP1A", "MYDGF", "MYH10", "MYH9", "MYL6", "MYO1C", "MYO6", "NAA35", "NADK2", "NAE1", "NAGLU", "NAMPT", "NANS", "NAPA", "NAPG", "NARS", "NAT10", "NAXE", "NCAPD2", "NCAPD3", "NCAPG", "NCAPG2", "NCAPH", "NCBP1", "NCKAP1", "NCL", "NCSTN", "ND1", "NDC1", "NDUFA11", "NDUFA13", "NDUFA4", "NDUFA5", "NDUFA7", "NDUFA8", "NDUFA9", "NDUFAF2", "NDUFAF3", "NDUFAF4", "NDUFAF7", "NDUFB1", "NDUFB10", "NDUFB3", "NDUFB4", "NDUFB5", "NDUFB6", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS6", "NDUFS7", "NDUFS8", "NDUFV1", "NDUFV2", "NECAP2", "NEFL", "NEK9", "NELFCD", "NELFE", "NHP2", "NIP7", "NIPSNAP2", "NLN", "NLRX1", "NME1", "NMT1", "NNT", "NOB1", "NOC2L", "NOC4L", "NOL11", "NOL6", "NOL9", "NOP14", "NOP2", "NOP56", "NOP58", "NOSIP", "NPC1", "NPC2", "NPEPPS", "NPLOC4", "NPM1", "NSD2", "NSDHL", "NSF", "NSMCE2", "NSUN2", "NT5C2", "NT5C3B", "NTHL1", "NUB1", "NUBP2", "NUBPL", "NUCB1", "NUDC", "NUDT1", "NUDT21", "NUDT5", "NUDT9", "NUF2", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP160", "NUP188", "NUP205", "NUP210", "NUP214", "NUP35", "NUP37", "NUP43", "NUP50", "NUP54", "NUP58", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NXF1", "OAT", "OCLN", "OCRL", "OGDH", "OGT", "OLA1", "OPA1", "OSBP", "OSBPL3", "OSBPL6", "OSBPL8", "OSBPL9", "OSGEP", "OTUB1", "OTUD7B", "OXA1L", "OXCT1", "P3H1", "P4HA1", "P4HB", "PA2G4", "PABPC1", "PABPN1", "PACSIN2", "PAF1", "PAFAH1B1", "PAFAH1B2", "PAFAH1B3", "PAICS", "PAIP1", "PAK2", "PANK4", "PAPOLA", "PARG", "PARK7", "PARN", "PARP1", "PATL1", "PBRM1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCK2", "PCLAF", "PCM1", "PCMT1", "PCNA", "PDAP1", "PDCD11", "PDCD6", "PDCD6IP", "PDE12", "PDE6D", "PDHA1", "PDHB", "PDIA3", "PDIA5", "PDIA6", "PDK3", "PDLIM5", "PDLIM7", "PDPR", "PDS5A", "PDS5B", "PDXK", "PEBP1", "PECR", "PELP1", "PES1", "PEX11A", "PEX14", "PEX16", "PEX19", "PEX5", "PFAS", "PFDN2", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGM3", "PGP", "PGRMC1", "PGRMC2", "PHAX", "PHB", "PHB2", "PHC2", "PHF5A", "PHGDH", "PHIP", "PHKA1", "PI4K2A", "PI4KB", "PICALM", "PIGK", "PIGS", "PIGT", "PIGU", "PIK3R4", "PIP4K2C", "PIR", "PISD", "PITPNB", "PITRM1", "PKM", "PKMYT1", "PKN1", "PKN2", "PLA2G15", "PLCG1", "PLD3", "PLD6", "PLEC", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLRG1", "PMF1", "PMPCA", "PMPCB", "PMVK", "PNKP", "PNO1", "PNP", "PNPLA6", "POFUT1", "POLA1", "POLA2", "POLD1", "POLD2", "POLD3", "POLDIP2", "POLDIP3", "POLE", "POLE3", "POLE4", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2A", "POLR2B", "POLR2C", "POLR2D", "POLR2E", "POLR2F", "POLR2G", "POLR2L", "POLR3A", "POLR3C", "POLRMT", "PON2", "POP1", "POR", "PPA1", "PPA2", "PPAT", "PPIB", "PPID", "PPIH", "PPIL1", "PPIL3", "PPIL4", "PPME1", "PPOX", "PPP1CA", "PPP1CB", "PPP1R12A", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP2R5E", "PPP3CA", "PPP4C", "PPP5C", "PPP6C", "PPP6R3", "PPT1", "PPT2", "PPWD1", "PRC1", "PRCC", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PRIM1", "PRIM2", "PRKAA2", "PRKACA", "PRKAG1", "PRKAR1A", "PRKAR2A", "PRKCB", "PRKCSH", "PRKDC", "PRKRA", "PRMT1", "PRMT3", "PRMT5", "PRPF19", "PRPF31", "PRPF4", "PRPF40A", "PRPF6", "PRPF8", "PSAP", "PSAT1", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD6", "PSMD7", "PSMD8", "PSMD9", "PSME1", "PSME2", "PSME3", "PSME4", "PTBP1", "PTCD3", "PTDSS1", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTPMT1", "PTPN1", "PTPN11", "PTPRF", "PTRH2", "PUDP", "PUF60", "PUM1", "PUS7", "PWP2", "PXMP2", "PXN", "PYCR1", "PYCR2", "PYCR3", "PYGB", "PYGL", "QARS", "QKI", "QTRT2", "RAB10", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB1B", "RAB21", "RAB24", "RAB31", "RAB39A", "RAB3GAP1", "RAB3GAP2", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RAB8A", "RAB9A", "RABEP1", "RABEPK", "RABGAP1", "RAC1", "RACGAP1", "RACK1", "RAD21", "RAD23A", "RAD23B", "RAD50", "RAE1", "RALA", "RAN", "RANBP1", "RANBP2", "RANBP9", "RANGAP1", "RAP2B", "RAPGEF2", "RARS", "RARS2", "RBBP5", "RBBP6", "RBBP7", "RBM14", "RBM17", "RBM22", "RBM28", "RBM4", "RBM5", "RBM8A", "RBMX", "RBP1", "RCC1", "RCC2", "RCL1", "RCN1", "RDH11", "RDH13", "RDH14", "RDX", "RETSAT", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RFT1", "RHEB", "RHOG", "RHOT1", "RHOT2", "RIDA", "RIF1", "RINT1", "RNASET2", "RNF139", "RNF14", "RNF20", "RNF40", "ROCK1", "RPA1", "RPA2", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPN1", "RPN2", "RPP30", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS28", "RPS29", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RPTOR", "RRBP1", "RRM1", "RRM2", "RRP1", "RRP36", "RRP8", "RRP9", "RSU1", "RTCB", "RTN3", "RTN4", "RTRAF", "RUFY1", "RUVBL1", "RUVBL2", "S100A11", "SACM1L", "SAE1", "SAFB", "SAMHD1", "SAMM50", "SAP18", "SARM1", "SARNP", "SARS", "SARS2", "SART1", "SCAMP1", "SCARB1", "SCARB2", "SCCPDH", "SCD", "SCFD1", "SCO1", "SCO2", "SCP2", "SCRIB", "SDCBP", "SDHA", "SDHB", "SEC11A", "SEC16A", "SEC22B", "SEC23A", "SEC23IP", "SEC24A", "SEC24B", "SEC24C", "SEC24D", "SEC31A", "SEC61A1", "SEC61B", "SEC61G", "SEH1L", "SEL1L", "SENP3", "SEPT2", "SEPT7", "SERPINB6", "SERPINH1", "SET", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SGPL1", "SGTA", "SH3GL1", "SHMT1", "SHMT2", "SIGMAR1", "SIN3A", "SIRT1", "SKIV2L", "SKIV2L2", "SKP1", "SKP2", "SLC16A1", "SLC19A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A17", "SLC25A19", "SLC25A20", "SLC25A21", "SLC25A22", "SLC25A26", "SLC25A32", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A4", "SLC30A5", "SLC30A6", "SLC33A1", "SLC35B2", "SLC39A14", "SLC3A2", "SLC4A7", "SLC6A15", "SLIT2", "SLK", "SLTM", "SMARCA4", "SMARCA5", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC6", "SMG5", "SMN1*", "SMNDC1", "SMPD4", "SMS", "SMYD3", "SNAP23", "SND1", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPC", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNW1", "SNX2", "SNX3", "SNX5", "SNX9", "SOAT1", "SOD2", "SORD", "SPAG9", "SPC24", "SPC25", "SPCS2", "SPEN", "SPHK2", "SPR", "SPTAN1", "SPTBN1", "SPTBN2", "SPTLC1", "SPTLC2", "SQLE", "SQSTM1", "SRI", "SRM", "SRP14", "SRP54", "SRP68", "SRP72", "SRP9", "SRPK1", "SRPK2", "SRPRA", "SRPRB", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF3", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSNA1", "SSR1", "SSR4", "SSRP1", "STAG1", "STAG2", "STAM", "STAMBP", "STARD3", "STARD3NL", "STARD7", "STAT1", "STAT3", "STIM1", "STIP1", "STK26", "STK4", "STMN1", "STOM", "STOML2", "STRAP", "STRN", "STT3A", "STX10", "STX18", "STX3", "STX4", "STX5", "STXBP3", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGT1", "SUN1", "SUN2", "SUPT16H", "SUPT5H", "SUPT6H", "SURF4", "SUZ12", "SV2A", "SYMPK", "SYNE2", "SYS1", "TAB1", "TACC3", "TADA3", "TAF15", "TAF6L", "TAGLN2", "TALDO1", "TAOK1", "TAP1", "TARS", "TARS2", "TBC1D13", "TBC1D15", "TBC1D4", "TBCA", "TBCB", "TBCD", "TBCE", "TBL3", "TCEA1", "TCP1", "TDRKH", "TECR", "TERF2IP", "TEX10", "TEX264", "TFAM", "TFB1M", "TFG", "TFIP11", "TFRC", "TGOLN2", "THOC1", "THOC2", "THOC3", "THOC5", "THOC6", "THOP1", "THRAP3", "THUMPD1", "TIA1", "TIAL1", "TIGAR", "TIMELESS", "TIMM10", "TIMM10B", "TIMM13", "TIMM17A", "TIMM17B", "TIMM23", "TIMM44", "TIMM50", "TIMM8B", "TIMM9", "TJP1", "TK1", "TKT", "TLN1", "TMED10", "TMED2", "TMED5", "TMED7", "TMED9", "TMEM126B", "TMEM30A", "TMEM59", "TMEM87A", "TMF1", "TMOD1", "TMOD3", "TMPO", "TMPO", "TMX3", "TNKS1BP1", "TNPO1", "TOMM20", "TOMM22", "TOMM40", "TOMM5", "TOMM70", "TOP1", "TOP2A", "TOP2B", "TOR1AIP1", "TOR1B", "TP53", "TPD52", "TPI1", "TPM1", "TPM3", "TPM4", "TPP1", "TPP2", "TPR", "TPX2", "TRA2B", "TRAF2", "TRAM1", "TRAP1", "TRAPPC5", "TRIM21", "TRIM25", "TRIM28", "TRIM33", "TRIP12", "TRMT10C", "TRMT11", "TRMU", "TRRAP", "TSFM", "TSG101", "TSN", "TSNAX", "TSPO", "TSR1", "TST", "TTC26", "TTC37", "TTLL12", "TTYH3", "TUBB", "TUBB2A", "TUBB2B", "TUBB3", "TUBB4B", "TUBB6", "TUBGCP2", "TUBGCP3", "TUBGCP4", "TUFM", "TWF1", "TWF2", "TWISTNB", "TWNK", "TXLNA", "TXNDC5", "TXNL1", "TXNRD1", "TYMS", "U2AF1", "U2AF2", "U2SURP", "UAP1", "UBA1", "UBA2", "UBA3", "UBA6", "UBAC1", "UBE2J1", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2O", "UBE2S", "UBE3A", "UBE4A", "UBQLN2", "UBR4", "UBTF", "UBXN1", "UBXN7", "UCHL5", "UCK2", "UFD1", "UFL1", "UGCG", "UGGT1", "UGP2", "UGT8", "UHRF1", "ULK3", "UMPS", "UNC119B", "UNG", "UPF1", "UQCR10", "UQCRB", "UQCRC1", "UQCRC2", "UQCRQ", "UROD", "USO1", "USP10", "USP11", "USP14", "USP28", "USP39", "USP47", "USP48", "USP5", "USP7", "USP9X", "UTP11", "UTP14A", "UTP15", "UTP18", "UTP20", "UTP3", "UTP4", "UTP6", "UTRN", "UXT", "VAMP7", "VANGL1", "VAPA", "VAPB", "VARS1", "VAT1", "VBP1", "VCL", "VCP", "VDAC1", "VDAC2", "VDAC3", "VIM", "VKORC1L1", "VPS26A", "VPS29", "VPS33B", "VPS35", "VPS37B", "VPS4A", "VPS4B", "VPS51", "VPS52", "VPS53", "VRK1", "VRK3", "WAPL", "WARS", "WBP11", "WDR1", "WDR11", "WDR12", "WDR18", "WDR3", "WDR34", "WDR36", "WDR43", "WDR46", "WDR48", "WDR5", "WDR6", "WDR61", "WDR75", "WDR77", "WFS1", "WIPI2", "WLS", "XAB2", "XPO1", "XPO5", "XPOT", "XRCC1", "XRCC5", "XRCC6", "XRN2", "YARS", "YARS2", "YBX1", "YIF1A", "YKT6", "YME1L1", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZC3H11A", "ZC3HAV1", "ZC3HC1", "ZCRB1", "ZFYVE16", "ZMYM2", "ZNF512B", "ZNF638", "ZW10", "ZWINT"], "leading_proteins": ["AAAS", "AASDHPPT", "ABCB1", "ABCB7", "ABCC1", "ABHD10", "ABHD12", "ACAT2", "ACOX1", "ACOX3", "ACSL3", "ACSL4", "ACTN1", "AGK", "AGPAT5", "AGPS", "AHCYL1", "AKT2", "ALDH3A2", "ALDH5A1", "ALG1", "ALG11", "ALG12", "ANAPC16", "ANAPC2", "ANAPC5", "ANAPC7", "ANKLE2", "ANO10", "ANO6", "ANXA1", "APLP2", "APOO", "APOOL", "APP", "ARF4", "ARFIP2", "ARL1", "ASAH1", "ASNA1", "ATAD1", "ATP13A1", "ATP1A1", "ATP2A2", "ATP2B1", "ATP5B", "ATP5F1", "ATP5I", "ATP5L", "ATP6", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1C1", "ATP6V1E1", "ATP7B", "B3GALT6", "B4GAT1", "BAG6", "BCAP31", "BNIP1", "BRD2", "BSG", "BUB1B", "C19orf70", "C1QBP", "CAB39", "CALU", "CAMK1", "CANX", "CASK", "CD320", "CD47", "CDC16", "CDC27", "CDC37", "CDIPT", "CDK4", "CDK6", "CDS2", "CERS1", "CERS2", "CETN2", "CHCHD3", "CHST14", "CKAP4", "CLCN3", "CLCN7", "COMT", "COPS3", "COQ9", "COX18", "COX2", "COX4I1", "COX5A", "CPT1A", "CPT2", "CRTAP", "CSNK1A1", "CSNK2A2", "CTNND1", "CTSA", "CTSB", "CYB5B", "CYB5R3", "CYC1", "CYP51A1", "DCTN2", "DCTN3", "DEGS1", "DERL1", "DERL2", "DHCR24", "DHCR7", "DHFR", "DHRS4", "DHRS7B", "DHX36", "DIABLO", "DLD", "DLG3", "DNAJC19", "DOHH", "DOLPP1", "DPAGT1", "ECE1", "EMD", "ENDOD1", "ENOPH1", "EPHX1", "ERAP1", "ERLIN1", "FADS2", "FAM49B", "FASN", "FDFT1", "FECH", "FGFR1OP", "FKBP14", "FKBP9", "FLOT1", "FNTA", "FNTB", "FUCA2", "GAL", "GALNT1", "GALNT4", "GBA", "GGCX", "GINS2", "GLA", "GLB1", "GLUD1", "GM2A", "GNAI2", "GNAI3", "GNG12", "GNPAT", "GOLGA5", "GOLGB1", "GOLIM4", "GOSR1", "GPAA1", "GRB2", "GTF2F1", "HACD2", "HACD3", "HADH", "HADHA", "HAUS1", "HAUS3", "HAUS4", "HAUS5", "HEXA", "HGS", "HLA-A", "HLA-B", "HLA-C", "HMGB1", "HMOX1", "HMOX2", "HNRNPA2B1", "HNRNPC", "HNRNPDL", "HNRNPF", "HNRNPK", "HS2ST1", "HSD17B11", "HSD17B12", "HSPA9", "ICMT", "IMMT", "IMPAD1", "ITCH", "ITGB1", "KDELR1", "KDSR", "KHDRBS1", "KIF18B", "KPNA2", "KPNA3", "L2HGDH", "LAMP2", "LAMTOR1", "LBR", "LEMD3", "LETM1", "LGALS3BP", "LMF2", "LMNA", "LMNB1", "LNPEP", "LPCAT1", "LPCAT3", "LPGAT1", "MAGT1", "MAIP1", "MAPK14", "MAVS", "MBOAT7", "MED25", "MFN1", "MFN2", "MGST2", "MGST3", "MIA2", "MICU2", "MIF", "MIPEP", "MMAB", "MOSPD2", "MOV10", "MSMO1", "MTAP", "MTCH1", "MTOR", "MTR", "MTX1", "MTX2", "NAGLU", "NCSTN", "ND1", "NDC1", "NDUFA11", "NDUFA13", "NDUFA4", "NDUFA8", "NDUFAF2", "NDUFAF7", "NDUFB1", "NDUFB10", "NDUFB3", "NDUFB4", "NDUFB5", "NDUFB6", "NDUFB9", "NELFCD", "NLN", "NLRX1", "NNT", "NPC1", "NUCB1", "NUP107", "NUP155", "NUP205", "NUP35", "NUP37", "NUP54", "NUP62", "NUP85", "NUP88", "NUP93", "NXF1", "OLA1", "P3H1", "P4HA1", "PDE6D", "PDHB", "PECR", "PEX14", "PEX16", "PEX19", "PEX5", "PGAM5", "PGRMC2", "PHB", "PHB2", "PI4KB", "PIGU", "PIP4K2C", "PISD", "PITRM1", "PLA2G15", "PLD3", "PLD6", "PLK1", "PMPCA", "PNPLA6", "POLR2A", "POLR2B", "POLR2C", "POLR2D", "POLR2E", "POLR2F", "POLR2L", "POLRMT", "PON2", "PPP2R1A", "PPP2R1B", "PPT1", "PPT2", "PRCP", "PREB", "PRKAA2", "PRKACA", "PRKAG1", "PRKAR1A", "PRKAR2A", "PRKRA", "PRMT1", "PSAP", "PSMB2", "PSMB4", "PSMB6", "PTGES2", "PTPMT1", "PTPN1", "PTPRF", "PTRH2", "PXMP2", "RAB10", "RAB1A", "RAB1B", "RAB24", "RAB31", "RAB5A", "RAB5B", "RAB7A", "RAB9A", "RABEPK", "RAE1", "RAN", "RDH11", "RDH13", "RETSAT", "RFT1", "RHEB", "RINT1", "RNF139", "RPS6KA3", "RTN3", "SACM1L", "SAMM50", "SCARB1", "SCCPDH", "SCD", "SCO1", "SCO2", "SCP2", "SDCBP", "SDHB", "SEC11A", "SEC22B", "SEC23A", "SEC61G", "SEH1L", "SEL1L", "SGPL1", "SH3GL1", "SLC16A1", "SLC19A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A13", "SLC25A15", "SLC25A17", "SLC25A21", "SLC25A22", "SLC25A26", "SLC25A32", "SLC25A4", "SLC25A5", "SLC25A6", "SLC30A5", "SLC30A6", "SLC33A1", "SLC35B2", "SLC39A14", "SLC4A7", "SLC6A15", "SLTM", "SOAT1", "SPHK2", "SPR", "SPTLC1", "SQLE", "SRPK2", "SRPRB", "SSBP1", "SSNA1", "SSR1", "STAM", "STARD3", "STARD3NL", "STARD7", "STIM1", "STOM", "STOML2", "STT3A", "STX10", "STX18", "STX4", "STX5", "SUCLG2", "SURF4", "SYS1", "TAP1", "TDRKH", "TECR", "TEX264", "TFAM", "TFRC", "TGOLN2", "TIMM10B", "TIMM13", "TIMM17A", "TIMM17B", "TIMM23", "TIMM44", "TIMM50", "TIMM8B", "TIMM9", "TMED10", "TMED2", "TMED7", "TMEM126B", "TMEM59", "TMEM87A", "TMPO", "TMX3", 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pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Electron transport chain oxphos system in mitochondria 18 49 3.8760366873630554 0.0001061716827892 17.57766990291262 50.45631067961165 1.00621396752225 0.3125021459260491 7.648293572467493 4.538458527560961 1.9412236823915887 0.3642771965747766 3.773248100664016e-09 7.092195860576647e-05 2.391679760144043e-05 2.039043455596799e-07 6.243939307529667e-09 +Nonalcoholic fatty liver disease 24 47 3.2059694010244693 0.001346083015413 14.446601941747574 49.78883495145631 0.8140299356769594 0.4039994838731682 5.918094936421778 5.382150615191258 1.5259550974793896 0.3817978315095583 0.0002073039343206 0.022467997482696 0.0319534517531922 0.0030476739012233 8.845861236294033e-05 +Sphingolipid metabolism integrated pathway 9 11 2.934189949016785 0.0033441948129944 4.058252427184466 8.101941747572816 1.3056837288293504 0.1731905617886817 2.1182299017960826 1.603786816240382 1.4154175704443392 0.233855234687812 9.116254034200944e-07 1.0 0.0137871179019738 3.5183496986754697e-06 1.1395112007455034e-06 +Sphingolipid metabolism overview 9 11 2.934189949016785 0.0033441948129944 4.0 7.951456310679611 1.305604070038762 0.1692072490812911 2.0060587839493125 1.5113078035984122 1.4254327231792938 0.2283290755268721 3.1818869380434205e-07 1.0 0.0111011801010317 1.6702585542338638e-06 3.987326650857323e-07 +Mitochondrial complex iv assembly 5 10 2.802949971704084 0.0050637523539494 4.645631067961165 11.985436893203884 1.036764412652062 0.2236438909453165 2.399566170297607 1.9080263664188637 1.5325215618909758 0.2795558816325345 0.0041137183930413 0.0115082778780227 0.0040337600577914 0.0011455603346848 0.0047506904504764 +Mitochondrial complex i assembly model oxphos system 12 27 2.7763809985683383 0.0054967753123129 8.808252427184467 26.563106796116504 0.7827212026364002 0.3851038550171766 4.050605834390814 3.9632288075289823 1.2210776523685654 0.3331428769936953 0.0001487071486373 0.2295798469686227 0.0932703984994284 0.0016731406324994 0.0001891471616549 +Sphingolipid pathway 8 11 2.70457118102217 0.0068392614968106 4.274271844660194 9.393203883495143 1.2258474538683668 0.1888473674707098 2.02173101931241 1.3620203536909472 1.3696572221543342 0.2416569853225122 3.888492764311224e-05 0.1006582454154426 0.0011273462404087 0.0001367419831176 4.695560421348397e-05 +Sphingolipid metabolism in senescence 7 13 2.680054659223193 0.0073610139383697 4.349514563106796 11.679611650485436 1.1898351622318797 0.2087194733713789 1.8732078185138223 1.4259290429724831 1.4063103725171229 0.2533781048666968 5.023113775580566e-06 0.1049896535105009 0.0012875484046766 0.000171368540682 6.247309740847078e-06 +Cholesterol metabolism with bloch and kandutschrussell pathways 11 24 2.6335584724877763 0.0084495285417831 7.092233009708738 23.070388349514563 1.3045876527781233 0.2885598195159411 3.1892169450204397 2.132138915277104 1.1515799969949023 0.3088028425519339 5.052948802747357e-08 0.1635258499471353 0.0480988323617951 2.180557064549601e-05 6.987772926919347e-08 +Overlap between signal transduction pathways contributing to lmna laminopathies 5 13 2.5843275016582097 0.0097569097386089 4.927184466019417 14.766990291262136 1.2077866030529698 0.2877996039599693 1.943257907759383 1.4611731122572065 0.935661776029738 0.2919054664837305 0.0163024133917279 1.0 0.3502020618548794 0.0215529467605083 0.0185916028453275 +Oxidative phosphorylation 16 32 2.5321732684011864 0.0113357960301074 10.094660194174756 30.308252427184467 0.4493106572238387 0.4094278581483465 4.631390429635194 3.3340884045985604 1.35936739882113 0.3321380007425058 1.889454349880709e-05 0.0257535715284909 0.0131741361742053 0.0013718552613534 2.4844402544872623e-05 +Ferroptosis 5 25 2.320767390993676 0.0202994013373289 6.247572815533981 23.589805825242717 0.9586016481897424 0.3324276931898122 2.8577723913591164 2.1450310521583007 1.2134257594151 0.3161491716459103 0.0083462479583922 0.2183067054048652 0.0846123699035222 0.0012377175637528 0.0097349382788801 +Metabolism of spingolipids in er and golgi apparatus 5 6 2.2510594213493795 0.0243817740828757 2.1432038834951457 4.12378640776699 1.255170581651192 0.2109312980793922 1.3711229283492827 1.3022449745711573 1.2018683368625842 0.2544377197345568 0.0022674499040627 1.0 0.1169218221283287 0.0368360647660487 0.0025257820396667 +Oxidation by cytochrome p450 3 6 2.183644448624344 0.0289883847136651 2.3179611650485437 5.422330097087379 1.262256455948566 0.1900711291682963 1.161003800051733 0.6764315332620536 1.214909583878196 0.2447393771863318 0.0022674499040627 0.0607401038440192 0.1169218221283287 0.0031665778749487 0.0025257820396667 +Allograft rejection 6 9 2.109443461462062 0.0349063213857576 3.3300970873786406 9.83980582524272 0.7953176037476221 0.3759733848734315 1.6481136585050014 1.3214319833302084 0.931941180031962 0.288328422601957 0.1578441973258112 1.0 1.0 1.0 0.0124755750562623 +Mitochondrial complex iii assembly 8 9 2.060857189448611 0.0393166665547928 3.3106796116504853 9.259708737864075 1.0287385637679851 0.2644162586394033 1.7668969355473032 1.3138647920792297 1.192785152283574 0.2813694304742245 0.0291172285701084 0.0697581245313758 0.0086772133501052 0.048077110185513 0.0314157626389551 +Statin inhibition of cholesterol production 3 6 2.035587988926255 0.041791744897651 2.0315533980582523 5.029126213592233 1.044092701346018 0.2144191485801186 1.2890406286437517 1.2084356467042294 1.2621579412510306 0.2395890160394713 0.0030601832000841 1.0 1.0 0.0423153882822146 0.003405063507905 +Familial partial lipodystrophy fpld 2 8 2.026971059316108 0.0426653724757057 2.7354368932038833 7.351941747572815 1.0487704575374006 0.2220749325398317 1.64741826657551 0.7567951823729889 1.2080189526980365 0.2461617416466816 0.0695538775916506 1.0 0.1820374447866984 0.0128055375372549 0.0746022325302512 diff --git a/msigdb_wp/metrics.json b/msigdb_wp/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..7598b56a74b093792ee0d095dbed08cc6d0a205f --- /dev/null +++ b/msigdb_wp/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2974, + "annotations_size": 590, + "title": "Average number of proteins per term", + "value": 9.891525423728813 +} \ No newline at end of file diff --git a/msigdb_wp/paths.json b/msigdb_wp/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..92e614bc785b89e500035f981a56f27fd493b395 --- /dev/null +++ b/msigdb_wp/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/msigdb_wp/fragment/C220/C220_val_log2fc"} \ No newline at end of file diff --git a/msigdb_wp/result.tsv b/msigdb_wp/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..e191f1d0b7d50c4dfca18d45c199030cbed9f837 --- /dev/null +++ b/msigdb_wp/result.tsv @@ -0,0 +1,105 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Electron transport chain oxphos system in mitochondria 0.6259293147731684 3.8760366873630545 0.0001061716827892 0.0607227838213623 0.0626412928456627 49 O95139,P24539,O14949,P13073,P00846,P14406,O43676,P12236,O75438,P00403,P22695,P12235,P21912,P03886,O96000,Q9UDW1,O75964,P05141 18 +Nonalcoholic fatty liver disease 0.5597322404191978 3.2059694010244693 0.001346083015413 0.5482941030536586 0.1354081763590217 47 P13073,P14406,Q86Y39,P00403,O96000,Q9UDW1,O95139,P31930,O43676,Q9Y6M9,P51970,O75438,O00483,O14949,Q9P0J0,P49327,O43674,P21912,P20674,Q96J02,P54646,P08574,O95168,P22695 24 +Sphingolipid metabolism integrated pathway 0.8055638482184959 2.934189949016785 0.0033441948129944 0.8614302523590788 0.1354081763590217 11 O15269,P27544,Q96G23,O95470,O15121,Q06136,Q9NRA0,Q13510,Q16739 9 +Sphingolipid metabolism overview 0.8055638482184959 2.934189949016785 0.0033441948129944 0.8614302523590788 0.1354081763590217 11 O15269,P27544,Q96G23,O95470,O15121,Q06136,Q9NRA0,Q13510,Q16739 9 +Mitochondrial complex iv assembly 0.8203654159221743 2.802949971704084 0.0050637523539494 0.9499735688565638 0.1354081763590217 10 Q9Y2R0,P13073,P14406,Q8N8Q8,O43819 5 +Mitochondrial complex i assembly model oxphos system 0.5792622634446223 2.7763809985683383 0.0054967753123129 0.9613049471855102 0.1354081763590217 27 O95139,Q8IUX1,Q9Y6M9,O43676,P51970,Q9P0J0,O75438,O95168,O43674,O96000,P03886,Q96CU9 12 +Sphingolipid pathway 0.7614003788380035 2.70457118102217 0.0068392614968106 0.9825606528468304 0.1354081763590217 11 O15269,P04062,O95470,Q96G23,Q06136,Q9NRA0,Q13510,Q16739 8 +Sphingolipid metabolism in senescence 0.7242016798078209 2.6800546592231935 0.0073610139383697 0.9872096146595926 0.1354081763590217 13 O15269,P04062,Q96G23,O15121,Q16739,Q13510,P16278 7 +Cholesterol metabolism with bloch and kandutschrussell pathways 0.5770246329247988 2.6335584724877763 0.0084495285417831 0.9933050557227228 0.1354081763590217 24 P35610,O00767,P37268,Q9BWD1,Q15800,O95864,P49327,Q14534,Q14739,Q16850,Q15392 11 +Overlap between signal transduction pathways contributing to lmna laminopathies 0.7072673415772532 2.5843275016582097 0.0097569097386089 0.9969262100367088 0.1404043108726659 13 P42167,P49354,O75844,O60725,P55209 5 +Oxidative phosphorylation 0.523419260906638 2.5321732684011864 0.0113357960301074 0.9988010584712728 0.1510515599972388 32 O95139,P24539,O75787,P00846,Q9Y6M9,P51970,Q86Y39,P56385,Q15904,O75438,O00483,O95168,O43674,P03886,O96000,O75964 16 +Ferroptosis 0.5318247454300614 2.3207673909936757 0.0202994013373289 0.9999944398011336 0.2054034938189253 25 P37268,P09601,Q9Y277,P45880,Q9NZ45 5 +Metabolism of spingolipids in er and golgi apparatus 0.8079514824797764 2.2510594213493795 0.0243817740828757 0.9999995266919194 0.2283372493475668 6 O95470,Q06136,Q9NRA0,Q10472,Q16739 5 +Oxidation by cytochrome p450 0.7932561244192523 2.183644448624344 0.0289883847136651 0.9999999709991488 0.2478716953777165 6 O43169,Q16850,Q6UW02 3 +Allograft rejection 0.7181095570808745 2.109443461462062 0.0349063213857576 0.999999999212976 0.2649236997616417 9 P08183,P49327,Q9BY49,P08670,P10321,P04439 6 +Mitochondrial complex iii assembly 0.7086003372681116 2.060857189448611 0.0393166665547928 0.9999999999472344 0.2729039207920913 9 P14927,P31930,P08574,Q9BRT2,Q6DKK2,P22695,O14949,Q9UDW1 8 +Statin inhibition of cholesterol production 0.7613715787423202 2.035587988926255 0.041791744897651 0.9999999999884828 0.2834152814898173 6 Q8WTV0,P37268,Q14534 3 +Familial partial lipodystrophy fpld 0.733158876507423 2.0269710593161077 0.0426653724757057 0.999999999993276 0.286051929098482 8 P49354,O75844 2 +Copper homeostasis 0.7413544241749057 1.941400751890896 0.0522096871781851 0.9999999999999818 0.3266319049998167 6 P35670,O43819,P05067,O75880 4 +Cholesterol biosynthesis with skeletal dysplasias 0.7830727958063901 1.909593883017052 0.0561855233291024 0.9999999999999984 0.3417469975687673 5 Q14739,Q16850,Q15392 3 +Degradation pathway of sphingolipids including diseases 0.7177423459304985 1.829099126930976 0.0673847597477459 1.0 0.3711582103021756 6 P06280,P17900,O43681,P16278 4 +Nanomaterial induced apoptosis 0.7649250091247505 1.827278844641131 0.0676578543761206 1.0 0.3711582103021756 5 Q9NR28,O95831,P49327 3 +Omega9 fatty acid synthesis 0.710191460806377 1.79291916695211 0.0729858500945819 1.0 0.384479031748244 6 P49327,O00767 2 +Photodynamic therapyinduced nfe2l2 nrf2 survival signaling 0.8170924846350709 1.7735225735950446 0.076142154757498 1.0 0.3975563832471138 4 P09601,Q16539 2 +Influence of laminopathies on wnt signaling 0.6503082316156318 1.7572580986649002 0.0788738263705379 1.0 0.4011685996432534 9 P49354,O75844,O60725 3 +Omega3 omega6 fatty acid synthesis 0.690928405685809 1.7000544696537363 0.0891206803500836 1.0 0.4296235367677846 6 Q15067,O95864 2 +Acquired partial lipodystrophy barraquersimons syndrome 0.730955821125457 1.6715671914433587 0.0946096988357849 1.0 0.4444456159274018 5 P49354 1 +Mitochondrial immune response to sarscov2 0.6318817497375961 1.659299469881477 0.0970554620557946 1.0 0.4444456159274018 9 Q86UT6,Q9Y6M9,Q9BQ95,P35232,Q99623 5 +Proteoglycan biosynthesis 0.7855218855218988 1.6371566923301235 0.1015977334124222 1.0 0.4506967121302943 4 Q8NCH0,Q9NX62,Q8TB61 3 +Glycerophospholipid biosynthetic pathway 0.6235352469650445 1.6146323360455268 0.1063903385276241 1.0 0.4649651831948018 9 O00116,O14735,O95674,Q8WUK0 4 +Tryptophan metabolism 0.532478280216403 1.6034483272332107 0.1088357086916902 1.0 0.467215536720847 14 P40939,P51648,P35610,Q15392 4 +Urea cycle and related diseases 0.912516823687756 1.594059766437107 0.1109226492015582 1.0 0.467215536720847 2 Q9Y619 1 +Zinc homeostasis 0.921575227196225 1.587283347231677 0.1124484851090852 1.0 0.467215536720847 3 Q8TAD4,Q6NXT4 2 +Monoamine transport 0.9017496635262496 1.5482482245534084 0.1215625447714261 1.0 0.4946338028630442 2 O15127 1 +Irinotecan pathway 0.8930013458950221 1.5110061057733368 0.1307868952460733 1.0 0.5152399478068012 2 O15118 1 +Adipogenesis 0.5279229105502773 1.500005139579394 0.1336130712109162 1.0 0.5152399478068012 13 O00767,O75844,P43490,P49327,Q9NZ45 5 +Liver x receptor pathway 0.8866083445491246 1.483784482925498 0.1378661049659948 1.0 0.5168005948207307 2 O00767 1 +Ketogenesis and ketolysis 0.6381191740437304 1.4416610932266845 0.1493980045181235 1.0 0.5474833705943659 6 P53985,P23786 2 +Metapathway biotransformation phase i and ii 0.4377060794062706 1.4296205066930283 0.1528259666626794 1.0 0.5509940484178641 20 Q99735,Q8NCH0,P07099,Q6UW02,P21964,Q16850,Q7LGA3 7 +Apoptosis modulation by hsp70 0.856998654104981 1.3577491034669045 0.1745433099148443 1.0 0.5732534745969659 2 P49327 1 +Nephrotic syndrome 0.550412138252939 1.3557379516641794 0.1751825596260268 1.0 0.5732534745969659 10 Q14108,O75844 2 +Vitamin d metabolism 0.8525748906092114 1.3121730064890391 0.1894617674595196 1.0 0.5856837882670137 3 P04062,P38435 2 +Progeriaassociated lipodystrophy 0.5348384379447156 1.265788981384803 0.2055886410096778 1.0 0.6095341617874872 10 P49354,O75844 2 +Glycosylation and related congenital defects 0.501555576644533 1.2151839086861025 0.2242959562537778 1.0 0.6392976530904779 11 Q9H3H5,Q9H0U3,Q9BT22,Q9BV10 4 +Vitamin d receptor pathway 0.4821193450205527 1.2042111211737063 0.2285079886192371 1.0 0.6402860710896043 13 P08183,Q92604,Q5VV42,Q96KA5 4 +Apoptosis modulation and signaling 0.4934449624057678 1.1653935068068493 0.2438597444333279 1.0 0.6465203008049567 11 O95831,Q07820,O43464,P49327,Q9NR28 5 +Neuroinflammation 0.8116292530430212 1.1491120056267148 0.2505097985314526 1.0 0.6473884842082935 3 P00403 1 +Triacylglyceride synthesis 0.610704453814916 1.1080367760594376 0.2678459336303143 1.0 0.6590129916881716 5 Q9NUQ2,O00116,Q99943 3 +Angiopoietinlike protein 8 regulatory pathway 0.3900979855538997 1.104077450032536 0.2695595422316375 1.0 0.6590129916881716 24 Q14254,P18031,O00767,Q16539,P54646,P41440,P49327,Q15418,P51812,O75955 10 +Glycerolipids and glycerophospholipids 0.5682974942903165 1.094017228777847 0.2739474220568185 1.0 0.6590129916881716 6 O14735,Q9UG56 2 +Hostpathogen interaction of human coronaviruses apoptosis 0.7907133243607068 1.0777986400660593 0.2811236265847183 1.0 0.6661162236344732 2 Q16539 1 +Sarscov2 and covid19 pathway 0.7908855991051936 1.066996176026331 0.2859735627176138 1.0 0.6744643519891482 3 Q8WTV0 1 +Nuclear receptors in lipid metabolism and toxicity 0.7870121130551846 1.0623511547050055 0.2880762994936701 1.0 0.6744643519891482 2 P08183 1 +Cholesterol biosynthesis pathway 0.4499695620717372 0.9941784147526348 0.3201360148115379 1.0 0.7245751956551192 13 Q16850,Q15800,Q14534 3 +Glycosaminoglycan degradation 0.5863905610160655 0.9934669348219428 0.3204824563564092 1.0 0.7245751956551192 5 P54802,P16278,P06865 3 +Endothelin pathways 0.5438681490742233 0.9719727608562952 0.3310640998921985 1.0 0.7261257209531492 6 P00403,P42892 2 +Intracellular trafficking proteins involved in cmt neuropathy 0.5054721436797529 0.9684592174938302 0.3328150772419134 1.0 0.7272625761952922 9 Q8TB36,Q9NR77,P07196,P04792,O95140,Q9UI14 6 +Type i collagen synthesis in the context of osteogenesis imperfecta 0.4501380429719704 0.9436628891601448 0.3453419438624094 1.0 0.7463433951605186 12 Q96AY3,P13674,O75718 3 +Spinal cord injury 0.413957424358203 0.9198181662381916 0.3576677885187138 1.0 0.7645796928479752 16 P14174,Q9NQC3,P62942,P08670,Q08722 5 +Photodynamic therapyinduced ap1 survival signaling 0.5161440439895375 0.9129615568820348 0.3612627605127803 1.0 0.7667087363400732 8 P49327,Q16539 2 +Regulation of apoptosis by parathyroid hormonerelated protein 0.7451861125756709 0.8884523624942043 0.3742974697145418 1.0 0.7721521228376911 3 Q9BXK5 1 +Ciliopathies 0.3905757170990779 0.8799827296168623 0.3788686654736612 1.0 0.776154557741181 18 O43924,Q13432 2 +Cellular proteostasis 0.6097643097643106 0.8676556224166871 0.3855828867067261 1.0 0.781765990230132 4 Q9UHV9,P61758,O15212 3 +Novel intracellular components of rigilike receptor rlr pathway 0.4763141194971638 0.8079059155297453 0.4191447456640711 1.0 0.8055224753804624 9 Q86UT6 1 +Nad metabolism sirtuins and aging 0.5857774168283932 0.7651330154357798 0.4441923419201119 1.0 0.816428292002698 4 P43490 1 +Histone modifications 0.5790388068608031 0.7366857968440571 0.4613134460857209 1.0 0.8323392452311171 4 Q01105 1 +Ppar signaling pathway 0.3857086346592234 0.7177759551114145 0.4728954414368425 1.0 0.8382377061343554 16 P50416,P22307,O00767,P23786,O15254,Q15067,O95864,Q16822 8 +Amyotrophic lateral sclerosis als 0.419853264847832 0.7136191964606118 0.4754626839897131 1.0 0.839889172317158 11 P07197,O96008,Q16539,Q9BUN8 4 +Proximal tubule transport 0.456681303831752 0.7008945255229854 0.4833688411586672 1.0 0.8465333767034273 9 P05023 1 +Riboflavin and coq disorders 0.5191487517713862 0.6823035034682416 0.4950470581975725 1.0 0.8590522480487288 5 O75208 1 +Oxidative stress response 0.4694269415969997 0.6071065766712708 0.5437801859150084 1.0 0.8738752925115656 6 P09601 1 +Alzheimers disease 0.292344031052524 0.6007245142596251 0.5480234885242021 1.0 0.8738752925115656 83 P49721,P21796,O95197,P28072,P16615,P12236,P49327,Q9NQC3,P12235,Q9Y277,P28070,P45880,P05141 13 +Leukocyteintrinsic hippo pathway functions 0.4650655180199641 0.5864243160342093 0.5575904077601992 1.0 0.8796212314933624 6 Q16539 1 +Mitochondrial long chain fatty acid betaoxidation 0.3824981447996216 0.5578778648361025 0.5769277875682994 1.0 0.8978846623357287 13 P50416,Q16836,P22307,O43772,P23786,P40939,Q9BY49 7 +Alzheimers disease and mirna effects 0.2892433554621448 0.547329817845459 0.5841521620102372 1.0 0.8998688657598956 84 P49721,P21796,O95197,P28072,P16615,P12236,P49327,Q9NQC3,P12235,Q9Y277,P28070,P45880,P05141 13 +Ccl18 signaling pathway 0.4201800985870155 0.5067699673519978 0.6123162311508967 1.0 0.9154931015002178 9 P08670,Q86UE4,P00403,P07196 4 +Apoptosis 0.398424963508968 0.4820914912321293 0.6297409540388315 1.0 0.918305665552002 10 Q9NR28,P49327,Q07820 3 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0.2472098622510515 0.8047458131662468 1.0 0.9818912943801332 5 O95470 1 +Factors and pathways affecting insulinlike growth factor igf1akt signaling 0.3790431266846331 0.2141633568408161 0.8304196701186839 1.0 0.9854372732731826 6 Q13418,P05556,Q8N122,P49770,P42345 5 +Pathways of nucleic acid metabolism and innate immune sensing 0.4024924216908035 0.2105512737266842 0.8332374377727021 1.0 0.9854372732731826 5 O00584,Q9Y3Z3,Q7Z434,O75792 4 +Steroid biosynthesis 0.5413862718707995 0.2089950653967548 0.8344520908032911 1.0 0.9854372732731826 2 P51659 1 +Gastric cancer network 2 0.3175834686259833 0.1999974713235883 0.8414825587631665 1.0 0.9854372732731826 14 Q86UE4 1 +Fatty acid betaoxidation 0.2907789778194465 0.1960624063253886 0.8445613205497888 1.0 0.9854372732731826 19 P50416,Q16836,P35610,P43304,O43772,P23786,P09622,P40939 8 +Vitamin b12 disorders 0.4289562289562212 0.1888242913762118 0.8502305325461843 1.0 0.9854372732731826 4 Q99707,Q9NPF0,Q96EY8 3 +Envelope proteins and their potential roles in edmd physiopathology 0.3081645964839843 0.1707844011766275 0.8643932949259647 1.0 0.9902758136045032 15 P42167,Q14739 2 +Aryl hydrocarbon receptor pathway wp2873 0.4151515151515182 0.1515571382733177 0.8795362414892376 1.0 0.9946202713438274 4 Q16543,O00170,Q15185 3 +Genes related to primary cilium development based on crispr 0.3430472187186406 0.1418843052646197 0.887171391475913 1.0 0.9946202713438274 9 A0AVF1,Q10713 2 +P53 transcriptional gene network 0.3571694570134205 0.1413703728106511 0.8875773582541684 1.0 0.9946202713438274 7 P49327 1 +Hostpathogen interaction of human coronaviruses mapk signaling 0.3559492689815327 0.1315764250424125 0.8953193334708376 1.0 0.998459460108294 6 P51812,Q16539 2 +Type ii interferon signaling ifng 0.3503734264569419 0.113125926975613 0.9099307201758268 1.0 1.0 6 Q03518 1 +Small cell lung cancer 0.3221997300944634 0.1069852651836137 0.9148006693385832 1.0 1.0 10 P04637,Q16611,P31751,Q12933,P63208,P05556,Q00534,P24941,P11802 9 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+{"all_annotations": ["15q112 copy number variation syndrome", "15q133 copy number variation syndrome", "16p112 distal deletion syndrome", "16p112 proximal deletion syndrome", "1q211 copy number variation syndrome", "22q112 copy number variation syndrome", "3q29 copy number variation syndrome", "4hydroxytamoxifen dexamethasone and retinoic acids regulation of p27 expression", "7oxoc and 7betahc pathways", "7q1123 copy number variation syndrome", "Ace inhibitor pathway", "Acetylcholine synthesis", "Acquired partial lipodystrophy barraquersimons syndrome", "Acute viral myocarditis", "Adipogenesis", "Aerobic glycolysis", "Aflatoxin b1 metabolism", "Agerage pathway", "Airway smooth muscle cell contraction", "Alanine and aspartate metabolism", "Allograft rejection", "Alpha 6 beta 4 signaling pathway", "Altered glycosylation of muc1 in tumor microenvironment", "Alternative pathway of fetal androgen synthesis", "Alzheimers disease", "Alzheimers disease and mirna effects", "Amino acid metabolism", "Amino acid metabolism pathway excerpt histidine catabolism extension", "Ampactivated protein kinase ampk signaling", "Amyotrophic lateral sclerosis als", "Androgen receptor signaling pathway", "Angiogenesis", "Angiopoietinlike protein 8 regulatory pathway", "Angiotensin ii receptor type 1 pathway", "Antiviral and antiinflammatory effects of nrf2 on sarscov2 pathway", "Apoptosis", "Apoptosis modulation and signaling", "Apoptosis modulation by hsp70", "Apoptosisrelated network due to altered notch3 in ovarian cancer", "Arachidonate epoxygenase epoxide hydrolase", "Arrhythmogenic right ventricular cardiomyopathy", "Aryl hydrocarbon receptor pathway wp2586", "Aryl hydrocarbon receptor pathway wp2873", "Atm signaling in development and disease", "Atm signaling pathway", "Atr signaling", "Autophagy", "Autosomal recessive osteopetrosis pathways", "B cell receptor signaling pathway", "Base excision repair", "Bdnftrkb signaling", "Benzene metabolism", "Benzoapyrene metabolism", "Bile acids synthesis and enterohepatic circulation", "Biogenic amine synthesis", "Biomarkers for pyrimidine metabolism disorders", "Biomarkers for urea cycle disorders", "Biotin metabolism including iems", "Bladder cancer", "Bmp2wnt4foxo1 pathway in primary endometrial stromal cell differentiation", "Brainderived neurotrophic factor bdnf signaling pathway", "Breast cancer pathway", "Burn wound healing", "Calcium regulation in cardiac cells", "Caloric restriction and aging", "Camkk2 pathway", "Cancer immunotherapy by ctla4 blockade", "Cancer immunotherapy by pd1 blockade", "Cannabinoid receptor signaling", "Canonical and noncanonical tgfb signaling", "Canonical nfkb pathway", "Cardiac hypertrophic response", "Cardiac progenitor differentiation", "Ccl18 signaling pathway", "Cell cycle", "Cell differentiation expanded index", "Cell differentiation index", "Cell migration and invasion through p75ntr", "Cells and molecules involved in local acute inflammatory response", "Cellular proteostasis", "Cerebral organic acidurias including diseases", "Chemokine signaling pathway", "Cholesterol biosynthesis pathway", "Cholesterol biosynthesis with skeletal dysplasias", "Cholesterol metabolism with bloch and kandutschrussell pathways", "Chromosomal and microsatellite instability in colorectal cancer", "Ciliary landscape", "Ciliopathies", "Circadian rhythm genes", "Classical pathway of steroidogenesis with glucocorticoid and mineralocorticoid metabolism", "Clear cell renal cell carcinoma pathways", "Codeine and morphine metabolism", "Cohesin complex cornelia de lange syndrome", "Common pathways underlying drug addiction", "Complement and coagulation cascades", "Complement system", "Complement system in neuronal development and plasticity", "Congenital generalized lipodystrophy cgl", "Constitutive androstane receptor pathway", "Control of immune tolerance by vasoactive intestinal peptide", "Copper homeostasis", "Cori cycle", "Corticotropinreleasing hormone signaling pathway", "Cysteine and methionine catabolism", "Cytoplasmic ribosomal proteins", "Cytosine methylation", "Cytosolic dnasensing pathway", "Ddx1 as a regulatory component of the drosha microprocessor", "Degradation pathway of sphingolipids including diseases", "Deregulation of rab and rab effector genes in bladder cancer", "Development of pulmonary dendritic cells and macrophage subsets", "Development of ureteric collection system", "Disorders of folate metabolism and transport", "Disruption of postsynaptic signaling by cnv", "Dna damage response", "Dna damage response only atm dependent", "Dna irdamage and cellular response via atr", "Dna irdouble strand breaks and cellular response via atm", "Dna mismatch repair", "Dna repair pathways full network", "Dna replication", "Dopamine metabolism", "Dopaminergic neurogenesis", "Drug induction of bile acid pathway", "Dual hijack model of vif in hiv infection", "Ebola virus infection in host", "Ebsteinbarr virus lmp1 signaling", "Ectoderm differentiation", "Effect of progerin on genes involved in hutchinsongilford progeria syndrome", "Egfegfr signaling pathway", "Egfr tyrosine kinase inhibitor resistance", "Eicosanoid metabolism via cyclooxygenases cox", "Eicosanoid metabolism via cytochrome p450 monooxygenases pathway", "Eicosanoid metabolism via lipooxygenases lox", "Eicosanoid synthesis", "Electron transport chain oxphos system in mitochondria", "Embryonic stem cell pluripotency pathways", "Endochondral ossification", "Endochondral ossification with skeletal dysplasias", "Endoderm differentiation", "Endometrial cancer", "Endoplasmic reticulum stress response in coronavirus infection", "Endothelin pathways", "Energy metabolism", "Envelope proteins and their potential roles in edmd physiopathology", "Epithelial to mesenchymal transition in colorectal cancer", "Epo receptor signaling", "Erbb signaling pathway", "Erk pathway in huntingtons disease", "Estrogen metabolism", "Estrogen receptor pathway", "Estrogen signaling pathway", "Ethanol effects on histone modifications", "Ethanol metabolism production of ros by cyp2e1", "Eukaryotic transcription initiation", "Exerciseinduced circadian regulation", "Exrna mechanism of action and biogenesis", "Extracellular vesiclemediated signaling in recipient cells", "Extracellular vesicles in the crosstalk of cardiac cells", "Factors and pathways affecting insulinlike growth factor igf1akt signaling", "Familial hyperlipidemia type 1", "Familial hyperlipidemia type 2", "Familial hyperlipidemia type 3", "Familial hyperlipidemia type 4", "Familial hyperlipidemia type 5", "Familial partial lipodystrophy fpld", "Farnesoid x receptor pathway", "Fas ligand pathway and stress induction of heat shock proteins", "Fatty acid betaoxidation", "Fatty acid biosynthesis", "Fatty acid omegaoxidation", "Fatty acid transporters", "Fbxl10 enhancement of maperk signaling in diffuse large bcell lymphoma", "Ferroptosis", "Fgfr3 signaling in chondrocyte proliferation and terminal differentiation", "Fibrin complement receptor 3 signaling pathway", "Fluoroacetic acid toxicity", "Fluoropyrimidine activity", "Focal adhesion", "Focal adhesion pi3kaktmtorsignaling pathway", "Folate metabolism", "Folatealcohol and cancer pathway hypotheses", "Follicle stimulating hormone fsh signaling pathway", "Foxa2 pathway", "Foxp3 in covid19", "Fragile x syndrome", "Fto obesity variant mechanism", "G protein signaling pathways", "G1 to s cell cycle control", "G13 signaling pathway", "Gaba metabolism aka ghb", "Gaba receptor signaling", "Gammaglutamyl cycle for the biosynthesis and degradation of glutathione including diseases", "Ganglio sphingolipid metabolism", "Gastric cancer network 1", "Gastric cancer network 2", "Gastrin signaling pathway", "Gdnfret signaling axis", "Genes controlling nephrogenesis", "Genes related to primary cilium development based on crispr", "Glial cell differentiation", "Glioblastoma signaling pathways", "Glucocorticoid receptor pathway", "Glucuronidation", "Glutathione metabolism", "Glycerolipids and glycerophospholipids", "Glycerophospholipid biosynthetic pathway", "Glycogen synthesis and degradation", "Glycolysis and gluconeogenesis", "Glycolysis in senescence", "Glycosaminoglycan degradation", "Glycosylation and related congenital defects", "Gpcrs class a rhodopsinlike", "Gpr143 in melanocytes and retinal pigment epithelium cells", "Gpr40 pathway", "H19 action rbe2f1 signaling and cdkbetacatenin activity", "Hair follicle development cytodifferentiation part 3 of 3", "Hair follicle development organogenesis part 2 of 3", "Head and neck squamous cell carcinoma", "Heart development", "Hedgehog signaling pathway wp4249", "Hedgehog signaling pathway wp47", "Hematopoietic stem cell gene regulation by gabp alphabeta complex", "Heme biosynthesis", "Hepatitis b infection", "Hepatitis c and hepatocellular carcinoma", "Hepatocyte growth factor receptor signaling", "Hereditary leiomyomatosis and renal cell carcinoma pathway", "Hif1a and pparg regulation of glycolysis", "Hijack of ubiquitination by sarscov2", "Hippo signaling regulation pathways", "Hippomerlin signaling dysregulation", "Hippoyap signaling pathway", "Histone modifications", "Homologous recombination", "Hostpathogen interaction of human coronaviruses apoptosis", "Hostpathogen interaction of human coronaviruses autophagy", "Hostpathogen interaction of human coronaviruses interferon induction", "Hostpathogen interaction of human coronaviruses mapk signaling", "Hypertrophy model", "Hypothesized pathways in pathogenesis of cardiovascular disease", "Id signaling pathway", "Il1 signaling pathway", "Il10 antiinflammatory signaling pathway", "Il17 signaling pathway", "Il18 signaling pathway", "Il2 signaling pathway", "Il3 signaling pathway", "Il4 signaling pathway", "Il5 signaling pathway", "Il6 signaling pathway", "Il7 signaling pathway", "Il9 signaling pathway", "Imatinib and chronic myeloid leukemia", "Immune response to tuberculosis", "Inclusion body myositis", "Influence of laminopathies on wnt signaling", "Inhibition of exosome biogenesis and secretion by manumycin a in crpc cells", "Initiation of transcription and translation elongation at the hiv1 ltr", "Insulin signaling", "Insulin signaling in adipocytes diabetic condition", "Insulin signaling in adipocytes normal condition", "Integrated cancer pathway", "Integrinmediated cell adhesion", "Interactions between immune cells and micrornas in tumor microenvironment", "Interactions between loxl4 and oxidative stress pathway", "Interactome of polycomb repressive complex 2 prc2", "Interferon type i signaling pathways", "Interleukin1 il1 structural pathway", "Interleukin1 induced activation of nfkb", "Interleukin11 signaling pathway", "Intracellular trafficking proteins involved in cmt neuropathy", "Intraflagellar transport proteins binding to dynein", "Irinotecan pathway", "Iron metabolism in placenta", "Joubert syndrome", "Kallmann syndrome", "Kennedy pathway from sphingolipids", "Ketogenesis and ketolysis", "Ketone bodies synthesis and degradation", "Kininkallikrein pathway", "Kisspeptinkisspeptin receptor system in the ovary", "Kit receptor signaling pathway", "Krebs cycle disorders", "Kynurenine pathway and links to cell senescence", "Leptin and adiponectin", "Leptin signaling pathway", "Leptininsulin signaling overlap", "Leukocyteintrinsic hippo pathway functions", "Linoleic acid metabolism affected by coronavirus infection", "Lipid metabolism pathway", "Liver x receptor pathway", "Lncrna in canonical wnt signaling and colorectal cancer", "Lncrnamediated mechanisms of therapeutic resistance", "Ltf danger signal response pathway", "Lung fibrosis", "Male infertility", "Malignant pleural mesothelioma", "Mammalian disorder of sexual development", "Mammary gland development pathway embryonic development stage 1 of 4", "Mammary gland development pathway involution stage 4 of 4", "Mammary gland development pathway pregnancy and lactation stage 3 of 4", "Mammary gland development pathway puberty stage 2 of 4", "Map3k1 role in promoting and blocking gonadal determination", "Mapk and nfkb signaling pathways inhibited by yersinia yopj", "Mapk cascade", "Mapk pathway in congenital thyroid cancer", "Mapk signaling pathway", "Matrix metalloproteinases", "Mbdnf and probdnf regulation of gaba neurotransmission", "Measles virus infection", "Mechanoregulation and pathology of yaptaz via hippo and nonhippo mechanisms", "Mecp2 and associated rett syndrome", "Melanoma", "Melatonin metabolism and effects", "Mesodermal commitment pathway", "Met in type 1 papillary renal cell carcinoma", "Metabolic pathway of ldl hdl and tg including diseases", "Metabolic reprogramming in colon cancer", "Metabolism of alphalinolenic acid", "Metabolism of spingolipids in er and golgi apparatus", "Metapathway biotransformation phase i and ii", "Metastatic brain tumor", "Methionine de novo and salvage pathway", "Methionine metabolism leading to sulfur amino acids and related disorders", "Methylation pathways", "Mevalonate arm of cholesterol biosynthesis pathway", "Mevalonate pathway", "Mfap5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement", "Mfap5mediated ovarian cancer cell motility and invasiveness", "Microglia pathogen phagocytosis pathway", "Microrna network associated with chronic lymphocytic leukemia", "Micrornas in cardiomyocyte hypertrophy", "Microtubule cytoskeleton regulation", "Mir124 predicted interactions with cell cycle and differentiation", "Mir517 relationship with arcn1 and usp1", "Mirna biogenesis", "Mirna regulation of dna damage response", "Mirna regulation of p53 pathway in prostate cancer", "Mirna regulation of prostate cancer signaling pathways", "Mirnas involved in dna damage response", "Mirnas involvement in the immune response in sepsis", "Mitochondrial complex i assembly model oxphos system", "Mitochondrial complex ii assembly", "Mitochondrial complex iii assembly", "Mitochondrial complex iv assembly", "Mitochondrial fatty acid synthesis pathway", "Mitochondrial gene expression", "Mitochondrial immune response to sarscov2", "Mitochondrial long chain fatty acid betaoxidation", "Modulators of tcr signaling and t cell activation", "Molybdenum cofactor moco biosynthesis", "Monoamine transport", "Mrna processing", "Mrna protein and metabolite inducation pathway by cyclosporin a", "Mthfr deficiency", "Myd88 distinct inputoutput pathway", "Myometrial relaxation and contraction pathways", "Nad biosynthetic pathways", "Nad metabolism", "Nad metabolism in oncogeneinduced senescence and mitochondrial dysfunctionassociated senescence", "Nad metabolism sirtuins and aging", "Nanomaterial induced apoptosis", "Nanomaterialinduced inflammasome activation", "Nanoparticle triggered autophagic cell death", "Nanoparticle triggered regulated necrosis", "Nanoparticlemediated activation of receptor signaling", "Ncrnas involved in stat3 signaling in hepatocellular carcinoma", "Ncrnas involved in wnt signaling in hepatocellular carcinoma", "Neovascularisation processes", "Nephrogenesis", "Nephrotic syndrome", "Netrinunc5b signaling pathway", "Network map of sarscov2 signaling pathway", "Neural crest cell migration during development", "Neural crest cell migration in cancer", "Neural crest differentiation", "Neurodegeneration with brain iron accumulation nbia subtypes pathway", "Neuroinflammation", "Neuroinflammation and glutamatergic signaling", "Nicotine effect on dopaminergic neurons", "Nipbl role in dna damage cornelia de lange syndrome", "Nitric oxide metabolism in cystic fibrosis", "Nocgmppkg mediated neuroprotection", "Nodlike receptor nlr signaling pathway", "Nonalcoholic fatty liver disease", "Nongenomic actions of 125 dihydroxyvitamin d3", "Nonhomologous end joining", "Nonsmall cell lung cancer", "Notch signaling", "Notch signaling pathway", "Notch1 regulation of endothelial cell calcification", "Novel intracellular components of rigilike receptor rlr pathway", "Nrf2 pathway", "Nrf2are regulation", "Nrp1triggered signaling pathways in pancreatic cancer", "Nsp1 from sarscov2 inhibits translation initiation in the host cell", "Nuclear receptors in lipid metabolism and toxicity", "Nuclear receptors metapathway", "Nucleotide excision repair", "Nucleotide excision repair in xeroderma pigmentosum", "Nucleotide metabolism", "Nucleotidebinding oligomerization domain nod pathway", "Oligodendrocyte specification and differentiation leading to myelin components for cns", "Omega3 omega6 fatty acid synthesis", "Omega9 fatty acid synthesis", "Oncostatin m signaling pathway", "Onecarbon metabolism", "Onecarbon metabolism and related pathways", "Orexin receptor pathway", "Osteoblast differentiation and related diseases", "Osteoclast signaling", "Osteopontin signaling", "Osx and mirnas in tooth development", "Ovarian infertility", "Overlap between signal transduction pathways contributing to lmna laminopathies", "Overview of interferonsmediated signaling pathway", "Overview of nanoparticle effects", "Oxidation by cytochrome p450", "Oxidative damage response", "Oxidative phosphorylation", "Oxidative stress response", "Oxysterols derived from cholesterol", "P38 mapk signaling pathway", "P53 transcriptional gene network", "Pancreatic adenocarcinoma pathway", "Parkinsons disease pathway", "Parkinubiquitin proteasomal system pathway", "Pathogenesis of sarscov2 mediated by nsp9nsp10 complex", "Pathogenic escherichia coli infection", "Pathways affected in adenoid cystic carcinoma", "Pathways of nucleic acid metabolism and innate immune sensing", "Pdgf pathway", "Pdgfrbeta pathway", "Pentose phosphate metabolism", "Pentose phosphate pathway in senescent cells", "Peroxiredoxin 2 induced ovarian failure", "Phase i biotransformations non p450", "Phosphodiesterases in neuronal function", "Phosphoinositides metabolism", "Photodynamic therapyinduced ap1 survival signaling", "Photodynamic therapyinduced hif1 survival signaling", "Photodynamic therapyinduced nfe2l2 nrf2 survival signaling", "Photodynamic therapyinduced unfolded protein response", "Physicochemical features and toxicityassociated pathways", "Physiological and pathological hypertrophy of the heart", "Pi3kakt signaling pathway", "Pi3kaktmtor signaling pathway and therapeutic opportunities", "Pi3kaktmtor vitd3 signaling", "Pilocytic astrocytoma", "Ppar signaling pathway", "Pparalpha pathway", "Praderwilli and angelman syndrome", "Pregnane x receptor pathway", "Preimplantation embryo", "Primary focal segmental glomerulosclerosis fsgs", "Prion disease pathway", "Progeriaassociated lipodystrophy", "Prolactin signaling pathway", "Prostaglandin and leukotriene metabolism in senescence", "Prostaglandin synthesis and regulation", "Proteasome degradation", "Proteoglycan biosynthesis", "Proximal tubule transport", "Ptf1a related regulatory pathway", "Purine metabolism", "Purine metabolism and related disorders", "Purinergic signaling", "Pyrimidine metabolism", "Pyrimidine metabolism and related diseases", "Rac1pak1p38mmp2 pathway", "Rala downstream regulated genes", "Ranklrank signaling pathway", "Ras and bradykinin pathways in covid19", "Ras signaling", "Regucalcin in proximal tubule epithelial kidney cells", "Regulation of actin cytoskeleton", "Regulation of apoptosis by parathyroid hormonerelated protein", "Regulation of sister chromatid separation at the metaphaseanaphase transition", "Regulation of wnt bcatenin signaling by small molecule compounds", "Regulatory circuits of the stat3 signaling pathway", "Relationship between inflammation cox2 and egfr", "Reninangiotensinaldosterone system raas", "Resistin as a regulator of inflammation", "Retinoblastoma gene in cancer", "Rett syndrome causing genes", "Riboflavin and coq disorders", "Robo4 and vegf signaling pathways crosstalk", "S1p receptor signal transduction", "Sars coronavirus and innate immunity", "Sarscov2 and covid19 pathway", "Sarscov2 b117 variant antagonises innate immune activation", "Sarscov2 innate immunity evasion and cellspecific immune response", "Sarscov2 replication organelle formation", "Selenium micronutrient network", "Serine metabolism", "Serotonin and anxiety", "Serotonin and anxietyrelated events", "Serotonin htr1 group and fos pathway", "Serotonin receptor 2 and elksrfgata4 signaling", "Serotonin receptor 467 and nr3c signaling", "Serotonin transporter activity", "Signal transduction through il1r", "Sleep regulation", "Small cell lung cancer", "Smc1smc3 role in dna damage cornelia de lange syndrome", "Somatroph axis gh and its relationship to dietary restriction and aging", "Sphingolipid metabolism in senescence", "Sphingolipid metabolism integrated pathway", "Sphingolipid metabolism overview", "Sphingolipid pathway", "Spinal cord injury", "Splicing factor nova regulated synaptic proteins", "Srebf and mir33 in cholesterol and lipid homeostasis", "Statin inhibition of cholesterol production", "Steroid biosynthesis", "Sterol regulatory elementbinding proteins srebp signaling", "Sting pathway in kawasakilike disease and covid19", "Striated muscle contraction pathway", "Sudden infant death syndrome sids susceptibility pathways", "Sulfation biotransformation reaction", "Supression of hmgb1 mediated inflammation by thbd", "Synaptic signaling pathways associated with autism spectrum disorder", "Synaptic vesicle pathway", "T cell receptor and costimulatory signaling", "Target of rapamycin tor signaling", "Tca cycle aka krebs or citric acid cycle", "Tca cycle and deficiency of pyruvate dehydrogenase complex pdhc", "Tca cycle in senescence", "Tca cycle nutrient use and invasiveness of ovarian cancer", "Tcell activation sarscov2", "Tcell antigen receptor tcr pathway during staphylococcus aureus infection", "Tcell receptor tcr signaling pathway", "Tgfbeta receptor signaling", "Tgfbeta receptor signaling in skeletal dysplasias", "Tgfbeta signaling in thyroid cells for epithelialmesenchymal transition", "Tgfbeta signaling pathway", "Thermogenesis", "Thiamine metabolic pathways", "Thymic stromal lymphopoietin tslp signaling pathway", "Thyroid hormones production and peripheral downstream signaling effects", "Thyroid stimulating hormone tsh signaling pathway", "Tlr4 signaling and tolerance", "Tnfalpha signaling pathway", "Tnfrelated weak inducer of apoptosis tweak signaling pathway", "Tolllike receptor signaling pathway", "Tolllike receptor signaling related to myd88", "Tp53 network", "Transcription cofactors ski and skil protein partners", "Transcription factor regulation in adipogenesis", "Transcription factors regulate mirnas related to cardiac hypertrophy", "Transcriptional activation by nrf2 in response to phytochemicals", "Translation factors", "Translation inhibitors in chronically activated pdgfra cells", "Transsulfuration and onecarbon metabolism", "Transsulfuration pathway", "Triacylglyceride synthesis", "Tryptophan catabolism leading to nad production", "Tryptophan metabolism", "Tumor suppressor activity of smarcb1", "Type 2 papillary renal cell carcinoma", "Type i collagen synthesis in the context of osteogenesis imperfecta", "Type i interferon induction and signaling during sarscov2 infection", "Type ii diabetes mellitus", "Type ii interferon signaling ifng", "Type iii interferon signaling", "Tyrobp causal network in microglia", "Ultraconserved region 339 modulation of tumor suppressor micrornas in cancer", "Unfolded protein response", "Urea cycle and associated pathways", "Urea cycle and metabolism of amino groups", "Urea cycle and related diseases", "Valproic acid pathway", "Vasopressinregulated water reabsorption", "Vegfavegfr2 signaling pathway", "Vitamin a and carotenoid metabolism", "Vitamin b12 disorders", "Vitamin b12 metabolism", "Vitamin b6dependent and responsive disorders", "Vitamin d in inflammatory diseases", "Vitamin d metabolism", "Vitamin d receptor pathway", "Vitamin dsensitive calcium signaling in depression", "White fat cell differentiation", "Wnt signaling", "Wnt signaling in kidney disease", "Wnt signaling pathway", "Wnt signaling pathway and pluripotency", "Wntbetacatenin signaling pathway in leukemia", "Zinc homeostasis"], "available_proteins": ["AAMP", "AAR2", "AARS", "AASS", "ABCB1", "ABCC1", "ABCD3", "ABCF1", "ABCF2", "ABI1", "ACAA2", "ACACA", "ACACB", "ACAD11", "ACAD9", "ACADM", "ACADVL", "ACAT1", "ACAT2", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT9", "ACOX1", "ACOX3", "ACP1", "ACP6", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN4", "ACTR2", "ACTR3", "ADAR", "ADH5", "ADI1", "ADRM1", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGL", "AGPAT1", "AGPAT5", "AGPS", "AHCY", "AHCYL1", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AKAP12", "AKAP13", "AKAP8", "AKR1A1", "AKR1B1", "AKR7A2", "AKT2", "ALDH18A1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALG1", "ALG11", "ALG12", "AMOT", "ANAPC1", "ANAPC2", "ANAPC5", "ANAPC7", "ANXA1", "ANXA2", "ANXA3", "ANXA4", "ANXA6", "AP1G1", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "APEX1", "APLP2", "APMAP", "APP", "APRT", "ARAF", "ARCN1", "ARF4", "ARF6", "ARFGAP1", "ARFGAP2", "ARFIP2", "ARHGDIA", "ARHGEF1", "ARHGEF2", "ARID1A", "ARIH2", "ARL2", "ARL3", "ARMC8", "ARPC1A", "ARPC2", "ARPC3", "ARPC4", "ARPC5", "ASAH1", "ASCC3", "ASNA1", "ASNS", "ATAD2", "ATG3", "ATG7", "ATG9A", "ATIC", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6", "ATP6AP1", "ATP6AP2", "ATP6V0D1", "ATP6V1A", "ATP6V1C1", "ATP6V1D", "ATP6V1E1", "ATP6V1H", "ATP7B", "ATPAF1", "ATPIF1", "ATRIP", "ATXN10", "ATXN2L", "AURKA", "AURKB", "B3GALT6", "BAG2", "BAG4", "BAIAP2", "BAK1", "BANF1", "BAZ1A", "BAZ1B", "BCL2L13", "BCLAF1", "BCS1L", "BLVRA", "BRAP", "BRIX1", "BSG", "BTAF1", "BTF3", "BUB1B", "BUB3", "BUD23", "C1QBP", "C21orf59", "CAB39", "CACYBP", "CAD", "CALD1", "CALM3", "CALR", "CALU", "CAMK1", "CAMK2G", "CAND1", "CAP1", "CAPN1", "CAPN2", "CAPZB", "CARM1", "CASK", "CBR1", "CBX1", "CBX3", "CBX5", "CCAR2", "CCDC124", "CCDC6", "CCNB1", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2AP", "CD2BP2", "CD320", "CD47", "CDC16", "CDC20", "CDC23", "CDC27", "CDC34", "CDC37", "CDC40", "CDC42", "CDC7", "CDC73", "CDH2", "CDIPT", "CDK1", "CDK2", "CDK4", "CDK5", "CDK6", "CDKAL1", "CDKN2A", "CDS2", "CEBPZ", "CECR2", "CELF2", "CEP290", "CEP44", "CERS1", "CERS2", "CETN2", "CFL1", "CFL2", "CHAF1A", "CHAMP1", "CHD1", "CHD1L", "CHD4", "CHKA", "CHMP5", "CHORDC1", "CHRAC1", "CHST14", "CHTF18", "CIP2A", "CISD1", "CKB", "CLASP1", "CLCN7", "CLIC1", "CLPTM1L", "CLTA", "CLTC", "CLU", "CLUH", "CMPK1", "CNOT1", "CNOT10", "CNOT9", "CNP", "COA3", "COASY", "COLEC12", "COLGALT1", "COMMD1", "COMT", "COPG1", "COPS2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS7A", "COPS8", "COQ8A", "COQ9", "COX18", "COX2", "COX4I1", "COX5A", "COX5B", "COX6C", "COX7A2", "CPNE1", "CPOX", "CPSF1", "CPSF2", "CPSF3", "CPT1A", "CPT2", "CRK", "CRKL", "CRTAP", "CS", "CSK", "CSNK1A1", "CSNK2A2", "CSNK2B", "CSRP2", "CSTB", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTCF", "CTNNA1", "CTNNB1", "CTNND1", "CTPS1", "CTPS2", "CTR9", "CTSA", "CTSB", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CYB5B", "CYB5R1", "CYB5R3", "CYC1", "CYFIP1", "CYFIP2", "CYP20A1", "CYP51A1", "DAG1", "DARS", "DAXX", "DBNL", "DCAF7", "DCTD", "DCTN1", "DCTN2", "DCTN4", "DCTPP1", "DDAH2", "DDB1", "DDOST", "DDX1", "DDX17", "DDX20", "DDX21", "DDX3X", "DDX5", "DDX52", "DDX56", "DEGS1", "DEK", "DERL1", "DFFA", "DGKE", "DHCR24", "DHCR7", "DHFR", "DHX15", "DHX16", "DHX29", "DHX36", "DHX38", "DHX8", "DHX9", "DIABLO", "DIAPH1", "DIAPH3", "DLAT", "DLD", "DLGAP5", "DLST", "DNAAF5", "DNAJA1", "DNAJB1", "DNAJC3", "DNAJC7", "DNAJC8", "DNM1L", "DNM2", "DNMT1", "DPAGT1", "DPM1", "DPP9", "DPYSL2", "DSC3", "DSG2", "DSP", "DSTN", "DTYMK", "DUSP3", "DUSP9", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNC1LI2", "DYNLL2", "ECE1", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECSIT", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EFTUD2", "EHD1", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B5", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF4A1", "EIF4A2", "EIF4B", "EIF4E", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAVL1", "ELMOD2", "ELOA", "ELOB", "ELOC", "ELP3", "EMD", "EML4", "ENAH", "ENO1", "ENO2", "ENOPH1", "EPB41", "EPB41L2", "EPB41L3", "EPB41L5", "EPHX1", "EPHX2", "EPRS", "EPS15L1", "ERCC2", "ERCC3", "ESD", "ESPL1", "ETF1", "ETFA", "ETFDH", "ETNK1", "EWSR1", "EXO1", "EXOC2", "EXOC3", "EXOC5", "EXOC6", "EXOC6B", "EXOC7", "EXOC8", "EXOSC2", "EXOSC7", "EXOSC9", "EZR", "F11R", "FABP5", "FADS2", "FAF1", "FAH", "FANCD2", "FANCI", "FARSB", "FASN", "FAU", "FDFT1", "FDPS", "FECH", "FEN1", "FGFR1OP", "FH", "FHL1", "FHOD1", "FIS1", "FKBP10", "FKBP1A", "FKBP2", "FKBP4", "FKBP5", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FMR1", "FNTA", "FOXRED1", "FSCN1", "FTL", "FTO", "FUCA1", "FUS", "FXR1", "FXR2", "G3BP1", "G6PD", "GABARAPL2", "GAL", "GALNT1", "GAPDH", "GART", "GBA", "GBE1", "GCC2", "GCDH", "GCLC", "GDAP1", "GDI1", "GFPT1", "GGCT", "GGCX", "GGH", "GGPS1", "GIGYF2", "GLA", "GLB1", "GLS", "GLUD1", "GM2A", "GMPPB", "GNA13", "GNAI2", "GNAI3", "GNG12", "GNPAT", "GNS", "GOT1", "GOT2", "GPAM", "GPAT4", "GPD2", "GPHN", "GPI", "GPS1", "GPT2", "GRB2", "GRSF1", "GSR", "GSS", "GSTK1", "GSTM3", "GSTO1", "GTF2B", "GTF2E1", "GTF2I", "GTPBP4", "GYG1", "GYS1", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HADH", "HADHA", "HADHB", "HAT1", "HCFC1", "HDAC1", "HDAC2", "HDGF", "HEBP1", "HELLS", "HEXA", "HEXB", "HGS", "HIBADH", "HIBCH", "HIRIP3", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLTF", "HMBS", "HMGA1", "HMGB1", "HMGB2", "HMGCL", "HMGCR", "HMGCS1", "HMOX1", "HNRNPA1", "HNRNPA2B1", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPK", "HNRNPL", "HNRNPM", "HNRNPR", "HNRNPU", "HPRT1", "HS2ST1", "HSD17B10", "HSD17B12", "HSD17B4", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA14", "HSPA1B", "HSPA2", "HSPA4", "HSPA8", "HSPA9", "HSPB1", "HSPD1", "HTRA2", "HUS1", "HYOU1", "IARS", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDI1", "IFT27", "IGF2BP1", "IGF2BP3", "IKBKG", "ILF2", "ILK", "IMP3", "IMPAD1", "IMPDH1", "IMPDH2", "IPO9", "IQGAP1", "IQGAP2", "IRS4", "ITCH", "ITGB1", "ITM2C", "ITPA", "IVD", "JUP", "KAT7", "KDM1A", "KDM1B", "KDM3B", "KDSR", "KHDRBS1", "KHSRP", "KIF15", "KIF22", "KIF23", "KIF2C", "KIF4A", "KIF5B", "KLC1", "KLC2", "KLC4", "KMT2A", "KPNA1", "KPNB1", "KTN1", "L2HGDH", "LARP1", "LARP7", "LARS2", "LBR", "LDHA", "LDHB", "LEMD3", "LGALS3BP", "LIG1", "LIG3", "LIPA", "LMNA", "LMNB1", "LMNB2", "LPCAT3", "LPGAT1", "LRP1", "LRPPRC", "LRRC59", "LRWD1", "LSM2", "LSM4", "LSM7", "LSS", "LTA4H", "LUC7L", "LZTFL1", "MACF1", "MAD2L1", "MAGT1", "MANF", "MAP1B", "MAP2K2", "MAP4", "MAPK1", "MAPK14", "MAPRE1", "MAPRE2", "MARS", "MAT2A", "MAT2B", "MAU2", "MAVS", "MBD3", "MCAT", "MCCC1", "MCCC2", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCU", "MDC1", "MDH1", "MDH2", "ME1", "ME2", "MECP2", "MEPCE", "METTL3", "MFN2", "MGST2", "MGST3", "MIA3", "MIF", "MKI67", "MMAB", "MOGS", "MORF4L1", "MOV10", "MPC2", "MPDU1", "MPG", "MPI", "MPP1", "MPST", "MRE11", "MRPL19", "MRPL40", "MSH2", "MSH3", "MSH6", "MSMO1", "MSN", "MTA1", "MTA2", "MTAP", "MTCH1", "MTDH", "MTHFD1", "MTHFD1L", "MTHFD2", "MTMR2", "MTOR", "MTR", "MUT", "MVK", "MYBBP1A", "MYCBP", "MYEF2", "MYH10", "MYH9", "MYL6", "MYO1C", "MYO6", "NAA15", "NAA40", "NAA50", "NAE1", "NAGLU", "NAMPT", "NAP1L1", "NAPA", "NARS", "NAT10", "NCAPG", "NCAPG2", "NCBP1", "NCDN", "NCKAP1", "NCL", "NCSTN", "ND1", "NDUFA11", "NDUFA13", "NDUFA4", "NDUFA5", "NDUFA7", "NDUFA8", "NDUFA9", "NDUFAF2", "NDUFAF3", "NDUFAF4", "NDUFAF7", "NDUFB1", "NDUFB10", "NDUFB3", "NDUFB4", "NDUFB5", "NDUFB6", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS6", "NDUFS7", "NDUFS8", "NDUFV1", "NDUFV2", "NEFL", "NEFM", "NEK9", "NELFCD", "NELFE", "NFATC2IP", "NKRF", "NLRX1", "NME1", "NONO", "NOP2", "NPC1", "NPC2", "NSDHL", "NSF", "NTHL1", "NUBPL", "NUDC", "NUDT21", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP214", "NUP62", "NUP88", "NUP98", "NXF1", "OAT", "OCLN", "OCRL", "OGDH", "OGT", "OPA1", "OSBPL3", "OTUD7B", "OXCT1", "OXSR1", "P3H1", "P4HA1", "P4HB", "PABPC1", "PABPN1", "PAF1", "PAFAH1B1", "PAICS", "PAIP1", "PAK2", "PAPOLA", "PARK7", "PARN", "PARP1", "PBK", "PBRM1", "PC", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCK2", "PCM1", "PCNA", "PDCD6", "PDCD6IP", "PDE12", "PDE6D", "PDHA1", "PDHB", "PDIA3", "PDIA6", "PDLIM5", "PDLIM7", "PDS5A", "PDS5B", "PEBP1", "PECR", "PELO", "PFAS", "PFDN2", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGM3", "PGRMC2", "PHB", "PHB2", "PHF5A", "PHF6", "PHGDH", "PHKA1", "PI4K2A", "PIBF1", "PIGT", "PIK3R4", "PIP4K2C", "PISD", "PKM", "PKMYT1", "PKN1", "PKN2", "PLCG1", "PLEC", "PLK1", "PLOD1", "PLOD2", "PMPCA", "PMVK", "PNKP", "PNP", "PNPT1", "PODXL", "POLA1", "POLA2", "POLD1", "POLD2", "POLD3", "POLDIP2", "POLE", "POLE3", "POLE4", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2A", "POLR2B", "POLR2C", "POLR2D", "POLR2E", "POLR2F", "POLR2G", "POLR2L", "POLR3A", "POLR3C", "POLRMT", "PON2", "POR", "PPAT", "PPIB", "PPID", "PPIF", "PPM1G", "PPOX", "PPP1CA", "PPP1CB", "PPP1R10", "PPP1R12A", "PPP1R8", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP2R5E", "PPP3CA", "PPP4C", "PPP4R1", "PPP4R3A", "PPP5C", "PPT2", "PRCC", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PRIM1", "PRIM2", "PRKAA2", "PRKACA", "PRKAG1", "PRKAR1A", "PRKAR2A", "PRKCB", "PRKDC", "PRKRA", "PRMT1", "PRMT3", "PRMT5", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRRC2C", "PSAT1", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD6", "PSMD7", "PSMD8", "PSMD9", "PSME1", "PSME2", "PSME3", "PSPC1", "PTBP1", "PTDSS1", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTPA", "PTPMT1", "PTPN1", "PTPN11", "PTPRF", "PTRH2", "PURA", "PXMP2", "PXN", "PYCR1", "PYCR2", "PYCR3", "PYGB", "PYGL", "QKI", "RAB10", "RAB13", "RAB14", "RAB21", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RAB8A", "RAB9A", "RABAC1", "RABGAP1", "RAC1", "RACGAP1", "RACK1", "RAD21", "RAD23A", "RAD23B", "RAD50", "RAE1", "RALA", "RAN", "RANBP1", "RANBP9", "RANGAP1", "RAPGEF2", "RARS", "RBBP7", "RBM14", "RBM17", "RBM39", "RBM4", "RBM5", "RBMX", "RBP1", "RCC1", "RCN1", "RDH14", "RDX", "RECQL", "RETSAT", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RHBDD2", "RHEB", "RHOG", "RIF1", "RNASEH2A", "RNASET2", "RNF139", "RNF14", "RNF20", "RNF40", "ROCK1", "RPA1", "RPA2", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPN1", "RPN2", "RPRD1B", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS28", "RPS29", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RPTOR", "RRBP1", "RRM1", "RRM2", "RTCB", "RTN3", "RTN4", "RUVBL1", "S100A11", "SACM1L", "SAFB", "SAMHD1", "SAP18", "SAR1A", "SARS", "SCAMP2", "SCARB1", "SCARB2", "SCD", "SCO1", "SCO2", "SCP2", "SCRIB", "SDCBP", "SDHA", "SDHB", "SEC23A", "SEC23B", "SEC24A", "SEC24B", "SEC24C", "SEC24D", "SEC31A", "SEL1L", "SEPT11", "SERBP1", "SERPINB6", "SERPINH1", "SET", "SEZ6L2", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SFPQ", "SGPL1", "SH3GL1", "SH3GLB1", "SHMT1", "SHMT2", "SIN3A", "SIRT1", "SKP1", "SKP2", "SLC16A1", "SLC19A1", "SLC1A5", "SLC25A1", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A19", "SLC25A20", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A4", "SLC30A5", "SLC30A6", "SLC33A1", "SLC35B2", "SLC39A14", "SLC3A2", "SLC4A7", "SLC6A15", "SLIT2", "SLTM", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMS", "SMYD3", "SNAP23", "SND1", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNW1", "SOAT1", "SOD2", "SPEN", "SPHK2", "SPNS1", "SPTAN1", "SPTBN1", "SPTLC1", "SPTLC2", "SQLE", "SQSTM1", "SRCAP", "SREK1", "SRM", "SRP54", "SRPK1", "SRPK2", "SRRM1", "SRSF1", "SRSF10", "SRSF3", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSNA1", "SSR4", "STAG1", "STAG2", "STAM", "STAMBP", "STAT1", "STAT3", "STIM1", "STIP1", "STK4", "STMN1", "STOM", "STRAP", "STRN", "STX3", "STX4", "STXBP3", "STXBP4", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGP2", "SUGT1", "SUN1", "SUPT5H", "SUZ12", "SYNE2", "TAB1", "TALDO1", "TAOK1", "TAP1", "TARDBP", "TBC1D4", "TBCA", "TBL2", "TCP1", "TECR", "TELO2", "TERF2IP", "TFAM", "TFB1M", "TFCP2", "TFRC", "THRAP3", "TIGAR", "TIMELESS", "TIPRL", "TJP1", "TK1", "TKT", "TLN1", "TMED10", "TMEM126B", "TMEM165", "TMEM38B", "TMEM43", "TMOD1", "TMOD3", "TMPO", "TMPO", "TNKS1BP1", "TNPO1", "TOMM40", "TOMM70", "TOP1", "TOP2A", "TOR1AIP1", "TP53", "TPI1", "TPM1", "TPM3", "TPM4", "TPP1", "TPX2", "TRA2A", "TRA2B", "TRAF2", "TRAM1", "TRAP1", "TRIM25", "TRIM28", "TRIM33", "TRIP13", "TRMT2A", "TRRAP", "TSG101", "TSPO", "TTC19", "TTC26", "TTK", "TUBB", "TUBB2A", "TUBB2B", "TUBB3", "TUBB4B", "TUBB6", "TUBGCP2", "TUBGCP3", "TUBGCP4", "TUFM", "TWISTNB", "TXNDC5", "TXNRD1", "TYMS", "U2AF1", "U2AF2", "UBA1", "UBA3", "UBAP2L", "UBE2J1", "UBE2L3", "UBE2N", "UBE3A", "UBR5", "UBTF", "UBXN7", "UCHL5", "UCK2", "UFD1", "UGCG", "UGGT1", "UGP2", "UGT8", "UHRF1", "ULK3", "UMPS", "UNC119", "UNG", "UPF1", "UQCC2", "UQCR10", "UQCRB", "UQCRC1", "UQCRC2", "UQCRQ", "UROD", "USP10", "USP5", "USP7", "USP9X", "UTRN", "VANGL1", "VAPA", "VAPB", "VARS1", "VBP1", "VCL", "VDAC1", "VDAC2", "VDAC3", "VIM", "VMP1", "VPS16", "VPS18", "VPS33A", "VPS37B", "VPS4A", "WAPL", "WARS", "WDHD1", "WDR1", "WDR26", "WDR34", "WDR48", "WDR5", "WFS1", "WIPI2", "XAB2", "XPNPEP3", "XPO1", "XPO5", "XRCC1", "XRCC5", "XRCC6", "XRN2", "YARS", "YARS2", "YBX1", "YBX3", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZC3H15", "ZFR", "ZFYVE16", "ZMPSTE24", "ZNF281", "ZNF318", "ZYX"], "leading_proteins": ["ABCB1", "ACAT2", "ACOX1", "ACOX3", "AGPAT1", "AGPAT5", "AGPS", "AIFM1", "AIP", "AKT2", "ALDH3A2", "ALG1", "ALG12", "APP", "ASAH1", "ASNA1", "ATP1A1", "ATP2A2", "ATP5F1", "ATP5I", "ATP5L", "ATP6", "ATP6AP1", "ATP6AP2", "ATP7B", "BAK1", "BCL2L13", "CAMK1", "CD320", "CD47", "CDC37", "CDIPT", "CDK2", "CDK4", "CDK6", "CDKAL1", "CDS2", "CERS1", "CERS2", "CHST14", "CISD1", "CLPTM1L", "CLU", "COA3", "COMT", "COQ9", "COX18", "COX2", "COX4I1", "COX5A", "COX7A2", "CPT1A", "CPT2", "CRTAP", "CYB5B", "CYC1", "CYP20A1", "CYP51A1", "DEGS1", "DERL1", 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https://git-lfs.github.com/spec/v1 +oid sha256:adb70d40dbbdfe26ed2431a06b1c477ae5f9baff1f6593b97c0b72e6c77cba78 +size 68381 diff --git a/opencell_localization/df_merge.tsv b/opencell_localization/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..0aed3a3248a0e3d82015dbdc618f53e2c3bbf582 --- /dev/null +++ b/opencell_localization/df_merge.tsv @@ -0,0 +1,4 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +er 51 86 4.818799071800858 1.4442490981432503e-06 29.17233009708738 87.61893203883496 1.3358083950399515 0.3757472714196316 13.465054065187209 8.223393744963309 2.0429537263872786 0.4010648005920765 2.9156095233861666e-21 0.148662677751522 0.000396243947003 6.190675981352218e-09 8.621233612040648e-21 +golgi 27 62 2.9713694657273173 0.0029647487653543 15.631067961165048 61.19417475728155 0.6692399314943925 0.523533703348586 6.922582002252161 5.868805558877078 1.075539554450533 0.3729249549278102 1.3388348929841456e-05 1.0 0.2496840539684075 0.0328851065710407 4.580687807043779e-06 +mitochondria 6 11 2.552510585269184 0.010694965966975 4.441747572815534 10.567961165048544 1.1937677940164793 0.2159787381789819 2.254231157409949 0.7391563798220593 1.4011905974754153 0.2980089661914649 0.0001907872283095 0.0017062060788896 0.0065261066260236 0.0031665778749487 1.4142727101836116e-05 diff --git a/opencell_localization/metrics.json b/opencell_localization/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..63fee35f1cad4faae853bbcc8a172880532c4854 --- /dev/null +++ b/opencell_localization/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2974, + "annotations_size": 17, + "title": "Average number of proteins per term", + "value": 91.52941176470588 +} \ No newline at end of file diff --git a/opencell_localization/paths.json b/opencell_localization/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..533e3033cb365b4090497d6d587bd147e19a80a8 --- /dev/null +++ b/opencell_localization/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/opencell_localization/fragment/C220/C220_val_log2fc"} \ No newline at end of file diff --git a/opencell_localization/result.tsv b/opencell_localization/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..29968717278e49c968aa8b325a0d28314652e6bc --- /dev/null +++ b/opencell_localization/result.tsv @@ -0,0 +1,6 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +er 0.6532821105581519 4.818799071800858 1.4442490981432503e-06 2.455195099415853e-05 2.4552234668452257e-05 86 O15269,Q15363,Q9NR31,P51151,O00400,O95470,Q969V3,O14735,Q96A33,Q5J8M3,Q15006,Q00765,Q13586,Q9Y5M8,Q9H6H4,P46977,P27824,P18085,Q9NTJ5,Q12981,Q969M3,O60499,Q14739,Q16850,P49755,P51572,Q15392,Q9NPA0,Q9P2W9,O15173,O00767,Q8NHH9,Q9Y487,O96005,Q9Y3E0,Q13190,Q07065,Q9NQC3,P61026,Q969Q5,O75915,Q15041,Q9UM00,Q8NF37,O75396,O15121,Q06136,O95674,Q9Y3C8,O00264,Q96N66 51 +golgi 0.4694129873598657 2.9713694657273173 0.0029647487653543 0.049222862912262 0.0168002430036746 62 Q9NR31,O14735,Q9Y371,Q8IXU6,Q9UI14,Q15437,Q8IZA0,P18085,Q15436,Q9NTJ5,P40616,Q969M3,Q8TAD4,P49755,Q5VW38,Q9Y487,Q9Y3E0,Q13190,P61026,O15127,Q9UBF8,Q8NBN3,Q9UM00,P62820,Q9H0U4,Q15904,O15258 27 +mitochondria 0.7328373023913475 2.5525105852691836 0.010694965966975 0.1670599924564779 0.0454536053596439 11 Q9NR31,Q15388,P21796,Q9Y277,P45880,Q969Q5 6 +vesicles 0.4387993045587803 1.745516781296151 0.080894953943235 0.7616541700813064 0.1964591738621423 168 Q7Z6M1,O15269,Q15363,P51151,O00400,Q9Y5X3,O95470,Q969V3,P41440,O14735,Q9Y371,P13473,Q10713,Q8IXU6,P05023,Q9UI14,Q9P253,Q15437,Q969T9,Q9H2J7,P20020,Q9H6H4,Q8IZA0,Q15436,Q969M3,O60499,P49755,P61421,Q15392,Q06481,P11279,P53985,O15400,O15173,Q5VW38,O00767,O96005,Q9Y3E0,P61026,P51798,O15127,Q9UBF8,O95249,Q9UNK0,Q93050,Q8IY95,Q8NBN3,Q9UM00,Q8NF37,O75396,P62820,Q9H0U4,O15121,Q15904,O95219,P04439,Q06136,P02786,Q86Y82,O43808,Q15758,O95674,O15258,O00264 64 +nuclear_membrane 0.3830194912377846 1.2391808957803745 0.2152785138413382 0.9837757642471624 0.365973473530275 32 P42167,O00505,Q8N6S5,Q8NFH5,Q14739,Q92973 6 diff --git a/opencell_localization/selections.json b/opencell_localization/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..5650a2353b6544012d66f8112c32e1f71970b60a --- /dev/null +++ b/opencell_localization/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["big_aggregates", "cell_contact", "centrosome", "chromatin", "cytoplasmic", "cytoskeleton", "er", "focal_adhesions", "golgi", "membrane", "mitochondria", "nuclear_membrane", "nuclear_punctae", "nucleolus_fc_dfc", "nucleolus_gc", "nucleoplasm", "vesicles"], "available_proteins": ["AAMP", "AATF", "ABCE1", "ACLY", "ACTN1", "ACTN4", "ACTR2", "AHCY", "AHSA1", "AKAP12", "AKAP13", "AKAP8L", "AKR1A1", "AKT2", "ALDH9A1", "ANAPC16", "ANAPC2", "ANKRD17", "ANXA11", "AP2B1", "AP2S1", "APLP2", "ARAF", "ARF4", "ARF6", "ARFGAP1", "ARFGAP2", "ARFIP1", "ARFIP2", "ARHGAP1", "ARHGAP17", "ARID1A", "ARL1", "ARL2", "ARL3", "ARL6IP1", "ARL6IP5", "ARL6IP6", "ARPC2", "ARPC3", "ATG3", "ATG4B", "ATG7", "ATG9A", "ATL2", "ATP1A1", "ATP2B1", "ATP6AP1", "ATP6AP2", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1D", "ATP6V1E1", "ATP6V1H", "ATXN10", "ATXN2L", "AURKB", "BAG4", "BAG6", "BAIAP2", "BANF1", "BAZ1A", "BAZ1B", "BCAP31", "BLVRA", "BMS1", "BNIP1", "BOP1", "BPNT1", "BRD2", "BTF3", "BUB1B", "BUD23", "BYSL", "C21orf59", "CAD", "CALD1", "CALM3", "CAMK1", "CAMK2G", "CANX", "CAPRIN1", "CAPZB", "CBX1", "CCAR1", "CCDC22", "CCDC47", "CCDC86", "CCNB1", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2BP2", "CDC16", "CDC20", "CDC23", "CDC27", "CDC37", "CDC42", "CDC7", "CDH2", "CDIPT", "CDK1", "CDK2", "CDK4", "CDK5", "CDKN2A", "CDS2", "CETN2", "CHMP1A", "CHMP2A", "CHMP2B", "CHMP3", "CHMP4B", "CHMP7", "CKAP2", "CKAP4", "CKAP5", "CKB", "CLASP1", "CLCN7", "CLINT1", "CLNS1A", "CLPTM1", "CLTA", "CLTC", "COIL", "COMMD1", "COPA", "COPB2", "COPE", "COPG1", "COPG2", "COPZ1", "CORO1B", "CORO1C", "CPSF6", "CSE1L", "CSK", "CSNK1A1", "CSNK2A2", "CSNK2B", "CTBP1", "CTBP2", "CTCF", "CTNNB1", "CTNNBL1", "CTPS1", "CTTN", "CYB5R3", "CYP51A1", "DAD1", "DBNL", "DCP1B", "DCTN2", "DDB1", "DDOST", "DDX21", "DDX39B", "DDX47", "DDX5", "DDX56", "DDX6", "DEGS1", "DHCR24", "DHX37", "DHX9", "DIAPH1", "DKC1", "DNAJA1", "DNAJA2", "DNAJB1", "DNAJC11", "DNAJC13", "DNAJC2", "DNAJC7", "DNAJC8", "DNAJC9", "DNM1L", "DNM2", "DOCK7", "DPH2", "DRG1", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNC1LI2", 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1.0 0.0030026383245846 0.0134810966360678 +glycosyltransferase 8 24 2.254772577801212 0.0241476073658319 6.910194174757281 21.383495145631063 0.4532445654278834 0.4839054526936805 3.459080207891436 3.770544939817097 1.1075266664550316 0.3364357117884409 0.0117854291891513 1.0 0.5403792944088247 0.0123970480938125 0.014075963110977 +oxidase 5 12 2.053104140022395 0.0400624785354437 5.111650485436893 13.890776699029129 1.1786899361665428 0.2351652471103072 2.6295852591466065 1.831549924215542 1.2715889014379809 0.2754701040210626 0.0631133577932044 0.0108643857486399 0.0390718495583504 0.0073773967902559 0.0688237498174009 +esterase 2 6 2.02271823251326 0.0431022060275805 2.0679611650485437 7.684466019417476 0.7172320192268422 0.3647762514846939 1.5217653004191571 1.4253091833924298 1.0863934099472772 0.3032327374846778 0.0778965395269367 1.0 1.0 0.0950158591305352 0.0834699588236698 diff --git a/panther_protein_class/metrics.json b/panther_protein_class/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..04689d85588ca7d6cd73d7e3b8d3333fc8faa92c --- /dev/null +++ b/panther_protein_class/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2974, + "annotations_size": 157, + "title": "Average number of proteins per term", + "value": 13.02547770700637 +} \ No newline at end of file diff --git a/panther_protein_class/paths.json b/panther_protein_class/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..5544b3fe06c022fdccc7c0a84af18f5b927d346b --- /dev/null +++ b/panther_protein_class/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/panther_protein_class/fragment/C220/C220_val_log2fc"} \ No newline at end of file diff --git a/panther_protein_class/result.tsv b/panther_protein_class/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..569c825b39fffda58c5a8497a7ad351f37e79b8b --- /dev/null +++ b/panther_protein_class/result.tsv @@ -0,0 +1,40 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +primary active transporter 0.7584533667602826 4.010473955591694 6.059698474913944e-05 0.0094688998178227 0.009513726605615 26 P35670,P05023,O96008,Q8N4H5,Q9H2J7,P20020,Q9NS69,Q96NB2,O75381,P60059,Q9Y5J7,Q9GZP9,P16615,Q9BUN8,Q15388,Q6NTF9,Q6P4A7,Q15758,O60888,Q9Y5J6 20 +transporter 0.5450222203226026 3.7299782910614634 0.0001914962691869 0.0296202539163529 0.0150324571311723 61 Q99595,O60830,Q96P70,P52292,O43615,O43681,O00505,Q6NXT4,Q9H2D1,Q8N8Q8,Q15070,Q9HD45,P53985,Q99805,Q567V2,Q9Y619,Q9NR77,Q9UJZ1,Q92973,P53007 20 +oxidoreductase 0.5613528737482607 3.0372871689903183 0.0023871791506302 0.3128723401722487 0.1060444908135674 41 O43169,O95825,O14949,Q8N0U8,P09622,Q9Y6M9,O43676,Q86Y39,O95831,P16435,P51970,Q9Y320,O15254,Q8N4Q0,P00403,Q15067,O95168,O96000 18 +secondary carrier transporter 0.7629895440787325 2.999777322715982 0.0027017704665877 0.3460680684900716 0.1060444908135674 14 Q9BQT8,O00400,O95202,Q15043,Q8TB61,Q96ES6,Q9UBX3 7 +calmodulin-related 0.7453369609614061 2.797979177885848 0.005142342757755 0.5548886424941443 0.1062195527011307 13 O43852,Q02818,Q8IYU8,Q99584,Q9BRK5,Q14257,P80303 7 +mitochondrial carrier protein 0.878624409979764 2.711320689684155 0.0067015776537784 0.6520474110084262 0.1062195527011307 8 Q9BSK2,Q9HC21,Q9NZJ7,Q86VD7,Q00325,Q70HW3,Q9Y6C9 7 +ATP synthase 0.600899559423052 2.6727679096611787 0.0075228277640262 0.6944216019990015 0.1062195527011307 20 Q93050,P24539,P00846,Q9Y487,P56385,Q15904,P61421,O75964 8 +transfer/carrier protein 0.7505407994347297 2.6470934288992485 0.008118691926201 0.7219173735668578 0.1062195527011307 11 Q9Y5M8,P12236,P17900,P12235,O15127,P05141 6 +SNARE protein 0.7212467207555078 2.489987327893528 0.0127747650012925 0.8671532462035145 0.1291124095504934 11 Q12846,Q9P2W9,O15400,Q86Y82,Q13190,O60499,Q9UNK0 7 +oxygenase 0.8386007372485783 2.457768538849281 0.0139803246010088 0.8903430322343516 0.1291124095504934 7 Q16850,P30519,P09601,Q14534 4 +serine protease 0.6289341052493501 2.3958713073217424 0.0165809107947696 0.92756214832002 0.1446223885988241 16 Q9H3G5,P42785,O14773,P10619,Q16740,P67812,Q8N2K0,Q9HB40,O43464,Q4J6C6 10 +membrane trafficking regulatory protein 0.6138449300209096 2.298967440678662 0.0215067882455695 0.9670710952287818 0.1565771823964998 16 P11279,P24390,Q14108,P13473,O00560,O43760,Q9P253,Q8WTV0 8 +acyltransferase 0.5639765135155365 2.281532019721613 0.0225169842024386 0.9720006756491792 0.1565771823964998 19 P50416,Q9NUQ2,P35610,Q8NF37,P23786,Q9BWD1,P49354,Q92604,Q8NCC3,P49356 10 +glycosyltransferase 0.52795202311695 2.254772577801212 0.0241476073658319 0.978456879477294 0.1565771823964998 24 Q8NBN7,P46977,Q8N4A0,Q9H3H5,Q9H0U3,Q9BV10,Q9BT22,Q16739 8 +oxidase 0.6300277841223993 2.053104140022395 0.0400624785354437 0.9983701565569904 0.209660304335489 12 P13073,P14406,Q8NB78,Q15800,O43819 5 +esterase 0.7586245177435412 2.02271823251326 0.0431022060275805 0.999009414702114 0.2114701983228169 6 Q9NUJ1,Q969T7 2 +protein modifying enzyme 0.4657022211834521 1.7501936913688725 0.0800848970476479 0.9999979657861692 0.3066665569873349 24 Q92791,Q9UMR5,O60725,P13674,P50897,O75718,Q86YN1 7 +voltage-gated ion channel 0.950521709861996 1.7020667978459243 0.0887428470994806 0.999999539076128 0.3178929429457088 3 P45880,P21796 2 +transmembrane signal receptor 0.6629661009615492 1.6767495513638948 0.0935914665464823 0.9999998005354438 0.3194317445173418 8 O75787,O15173,Q99720,Q8WUJ1,O00264 5 +metalloprotease 0.4486492383063861 1.6653543735759475 0.0958420765208345 0.9999998649937332 0.3201533194419366 26 Q9NZ08,P42892,Q5JRX3,Q9UIQ6,P55786,P31930,O75844,P02786,Q99797,Q10713,Q9BYT8,P22695 12 +ATP-binding cassette (ABC) transporter 0.6716377432777836 1.6062774108270217 0.1082129713183097 0.999999984476104 0.3467231938158088 6 P08183,O75027,Q03518,P33527 4 +transferase 0.4124551284941994 1.4417934288646828 0.1493606571924217 0.9999999999906668 0.3992570760298899 29 P37268,Q99735,O14880,Q8NCH0,P43490,O95674,O43505,Q7LGA3,Q2TAA5 9 +major histocompatibility complex protein 0.7321323440019449 1.4039450062793386 0.1603352262448272 0.9999999999987847 0.4060101696844818 4 P10321,P04439 2 +galactosidase 0.8694042409962947 1.3793486092277516 0.1677872959737212 0.9999999999997002 0.4116032104355348 3 P06280,P16278 2 +ion channel 0.6086735187908998 1.345174346041949 0.1785689387103535 0.9999999999999613 0.4235910276556628 7 Q9C0H2,P51798,Q96S66 3 +phospholipase 0.59780457977581 1.2898217025689909 0.1971125708882999 0.9999999999999988 0.4235910276556628 7 Q8N2A8,Q8NHP8 2 +G-protein coupled receptor 0.8463848752870775 1.2874750180041228 0.1979287715945252 0.9999999999999992 0.4235910276556628 3 Q5VW38 1 +methyltransferase 0.4729212215045689 1.2079221317709552 0.2270772157129412 1.0 0.4630015956744386 14 Q9BV86,Q9H8H3 2 +amino acid transporter 0.7963648603163789 1.0886385872940665 0.2763132934459174 1.0 0.5164427032262979 3 O14925,O60831 2 +dehydrogenase 0.3075286326895157 1.0045065413491472 0.3151345198584985 1.0 0.5313074496571842 66 Q96CU9,Q9P0J0,O75438,Q3SXM5,Q9NZ01,Q8WWV3,P51648,Q13423,P03886,Q96LJ7 10 +G-protein 0.5885956114204534 1.0038364420548314 0.315457455921742 1.0 0.5313074496571842 5 Q9NTK5,P18085 2 +membrane traffic protein 0.2998057566867456 0.8971753744531826 0.3696253433672631 1.0 0.5803117890866032 66 Q9H6H4,Q12907,Q5THJ4,Q9NX40,P43307,O60313,Q96PC5,Q8N2H4,Q13432,P40855,O43493,Q00765,P51572,Q9UI14,A6NIH7 15 +lyase 0.4184271973193727 0.7049744924596831 0.4808261101106681 1.0 0.68626999352159 11 Q9UHG3,P22830,P53701 3 +chaperone 0.2664964935322493 0.434673553701471 0.6637993972107066 1.0 0.8308410721203843 66 O14657,Q9Y680,Q9Y2R0,O15260,Q96KC8,P27824,Q96JJ7,Q9H497,Q9NWM8,P46379,Q9BRT2,P49321,P62942,Q15006 14 +decarboxylase 0.6077278301604595 0.3996995088671011 0.689377853901068 1.0 0.8308410721203843 3 Q9UG56 1 +apolipoprotein 0.4875065939127063 0.3765513145265065 0.7065070742209747 1.0 0.8308410721203843 4 Q9BQE5 1 +kinase 0.298262588754066 0.298758351700892 0.7651244308599008 1.0 0.8642052924101037 20 Q53H12,Q8WVC6,Q9UBF8,Q9BRR6,P52789 5 +glycosidase 0.3870930535005071 0.1608443141275609 0.8722160219740611 1.0 0.9186821097009576 5 Q9BTY2,P06865 2 +mRNA capping factor 0.3058546433378135 0.0048333056802816 0.9961435950348808 1.0 1.0 2 Q8IZD4 1 diff --git a/panther_protein_class/selections.json b/panther_protein_class/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..2bb170d6605b5a196c62514dcc6c24698b31afd7 --- /dev/null +++ b/panther_protein_class/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["ATP synthase", "ATP-binding cassette (ABC) transporter", "C2H2 zinc finger transcription factor", "DNA glycosylase", "DNA helicase", "DNA ligase", "DNA metabolism protein", "DNA methyltransferase", "DNA polymerase processivity factor", "DNA topoisomerase", "DNA-binding transcription factor", "DNA-directed DNA polymerase", "DNA-directed RNA polymerase", "G-protein", "G-protein coupled receptor", "G-protein modulator", "GTPase-activating protein", "Hsp90 family chaperone", "P53-like transcription factor", "RNA helicase", "RNA metabolism protein", "RNA methyltransferase", "RNA processing factor", "RNA splicing factor", "SNARE protein", "acetyltransferase", "actin and actin related protein", "actin binding motor protein", "actin or actin-binding cytoskeletal protein", "acyltransferase", "aldolase", "amino acid kinase", "amino acid transporter", "aminoacyl-tRNA synthetase", "amylase", "antimicrobial response protein", "apolipoprotein", "aspartic protease", "basic leucine zipper transcription factor", "cadherin", "calcium-binding protein", "calmodulin-related", "carbohydrate kinase", "cell adhesion molecule", "centromere DNA-binding protein", "chaperone", "chaperonin", "chromatin/chromatin-binding, or -regulatory protein", "cyclase", "cysteine protease", "cytokine", "cytoskeletal protein", "damaged DNA-binding protein", "deaminase", "decarboxylase", "defense/immunity protein", "dehydratase", "dehydrogenase", "endodeoxyribonuclease", "endoribonuclease", "epimerase/racemase", "esterase", "exodeoxyribonuclease", "exoribonuclease", "extracellular matrix glycoprotein", "extracellular matrix protein", "extracellular matrix structural protein", "galactosidase", "general transcription factor", "glucosidase", "glycosidase", "glycosyltransferase", "growth factor", "guanyl-nucleotide exchange factor", "heterotrimeric G-protein", "histone", "histone modifying enzyme", "homeodomain transcription factor", "hydratase", "hydrolase", "hydroxylase", "integrin", "intercellular signal molecule", "intermediate filament binding protein", "ion channel", "isomerase", "kinase", "kinase activator", "kinase inhibitor", "kinase modulator", "ligase", "lipase", "lyase", "mRNA capping factor", "mRNA polyadenylation factor", "major histocompatibility complex protein", "membrane traffic protein", "membrane trafficking regulatory protein", "metalloprotease", "methyltransferase", "microtubule binding motor protein", "microtubule or microtubule-binding cytoskeletal protein", "mitochondrial carrier protein", "mutase", "non-motor actin binding protein", "non-motor microtubule binding protein", "non-receptor serine/threonine protein kinase", "nucleic acid metabolism protein", "nucleotide kinase", "nucleotide phosphatase", "nucleotidyltransferase", "oxidase", "oxidoreductase", "oxygenase", "peptide hormone", "peroxidase", "phosphatase", "phosphatase activator", "phosphatase modulator", "phosphodiesterase", "phospholipase", "primary active transporter", "primase", "protease", "protease inhibitor", "protein modifying enzyme", "protein phosphatase", "protein-binding activity modulator", "pyrophosphatase", "reductase", "ribosomal protein", "scaffold/adaptor protein", "secondary carrier transporter", "serine protease", "small GTPase", "storage protein", "structural protein", "tight junction", "transaminase", "transcription cofactor", "transfer/carrier protein", "transferase", "transketolase", "translation elongation factor", "translation factor", "translation initiation factor", "translation release factor", "translational protein", "transmembrane signal receptor", "transporter", "tubulin", "tyrosine protein kinase receptor", "ubiquitin-protein ligase", "vesicle coat protein", "viral or transposable element protein", "voltage-gated ion channel", "zinc finger transcription factor"], "available_proteins": ["AAR2", "AARS", "AARS2", "AASDHPPT", "AASS", "AATF", "ABCB1", "ABCB7", "ABCC1", "ABCD3", "ABCF1", "ABCF2", "ABCF3", "ABHD10", "ABHD12", "ABHD6", "ABI1", "ACAA2", "ACAD11", "ACAD9", "ACADM", "ACADVL", "ACAT1", "ACAT2", "ACBD5", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT9", "ACOX1", "ACOX3", "ACP1", "ACP2", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTR10", "ACTR1A", "ACTR1B", "ACTR2", "ACTR3", "ADAR", "ADD1", "ADD3", "ADH5", "ADI1", "ADPGK", "ADPRHL2", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGK", "AGPAT1", "AGPAT5", "AHCY", "AHCYL1", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AKAP12", "AKAP8", "AKAP8L", "AKR1A1", "AKR1B1", "AKR7A2", "AKT2", "ALDH18A1", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALG1", "ALG11", "ALG12", "ALKBH5", "ALYREF", "ANAPC1", "ANAPC7", "ANGEL1", "ANKFY1", "ANKHD1", "ANKRD17", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA3", "ANXA4", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP1M1", "AP1S2", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "AP3S1", "APEH", "APLP2", "APOL2", "APP", "APRT", "ARAF", "ARCN1", "ARF4", "ARF6", "ARFGAP1", "ARFGAP2", "ARFIP1", "ARFIP2", "ARHGAP1", "ARHGDIA", "ARHGEF1", "ARID3B", "ARIH1", "ARIH2", "ARL1", "ARL6IP5", "ARPC1A", "ARPC3", "ARPC4", "ARPC5", "ASAH1", "ASCC3", "ASNA1", "ASNS", "ASPH", "ATAD2", "ATE1", "ATG3", "ATG4B", "ATG7", "ATL2", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6", "ATP6AP1", "ATP6AP2", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1D", "ATP6V1H", "ATP7B", "ATPAF1", "ATPIF1", "ATXN2L", "AUP1", "AURKA", "AURKB", "B3GALT6", "B4GAT1", "BAG2", "BAG6", "BAIAP2", "BCAP31", "BCAS2", "BCLAF1", "BLMH", "BLVRA", "BOP1", "BPHL", "BPNT1", "BRIX1", "BSG", "BTF3", "BUB1B", "BUB3", "BUD23", "BUD31", "BZW1", "BZW2", "CACYBP", "CAD", "CALD1", "CALM3", "CALR", "CALU", "CAMK1", "CAMK2G", "CAND1", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPRIN1", "CAPZA1", "CAPZA2", "CAPZB", "CARM1", "CARS", "CARS2", "CASK", "CAST", "CBR1", "CBX8", "CCAR1", "CCAR2", "CCNB1", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2BP2", "CD320", "CD47", "CDC16", "CDC20", "CDC23", "CDC27", "CDC37", "CDC40", "CDC42", "CDC7", "CDH2", "CDIPT", "CDK1", "CDK2", "CDK4", "CDK5", "CDK6", "CDS2", "CEBPZ", "CETN2", "CFL1", "CFL2", "CHAF1A", "CHAF1B", "CHERP", "CHKA", "CHMP1A", "CHMP2A", "CHMP2B", "CHMP3", "CHMP4B", "CHMP5", "CHMP7", "CHORDC1", "CHRAC1", "CHST14", "CHTF18", "CKAP2", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLCC1", "CLCN3", "CLCN7", "CLGN", "CLIC1", "CLIC4", "CLNS1A", "CLPB", "CLPP", "CLPX", "CLTA", "CLTC", "CLUH", "CMAS", "CMPK1", "CMSS1", "CNDP2", "CNN3", "CNOT1", "CNOT2", "CNP", "COA3", "COASY", "COG4", "COIL", "COLEC12", "COLGALT1", "COMT", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS8", "COPZ1", "CORO1B", "CORO1C", "CORO7", "COTL1", "COX18", "COX2", "COX4I1", "COX5A", "COX5B", "COX7A2", "CPD", "CPOX", "CPSF1", "CPSF3", "CPSF6", "CPSF7", "CPT1A", "CPT2", "CPVL", "CRK", "CRKL", "CRNKL1", "CROT", "CRTAP", "CRYZL1", "CS", "CSE1L", "CSNK1A1", "CSNK2B", "CSRP2", "CSTB", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTCF", "CTNNA1", "CTNND1", "CTPS1", "CTPS2", "CTR9", "CTSA", "CTSB", "CTSC", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CUTA", "CWC27", "CYB5B", "CYB5D2", "CYB5R1", "CYB5R3", "CYFIP1", "CYFIP2", "CYP20A1", "CYP51A1", "DAD1", "DAG1", "DAP3", "DARS", "DARS2", "DBN1", "DBNL", "DBT", "DCAF13", "DCAKD", "DCP1B", "DCPS", "DCTD", "DCTN1", "DCTN2", "DCTN3", "DCTN4", "DCTPP1", "DCXR", "DDAH2", "DDB1", "DDI2", "DDOST", "DDT", "DEGS1", "DEK", "DENR", "DERL1", "DERL2", "DGKE", "DHCR24", "DHCR7", "DHFR", "DHRS1", "DHRS4", "DHRS7", "DHRS7B", "DHX15", "DHX16", "DHX29", "DHX30", "DHX36", "DHX37", "DHX38", "DHX40", "DHX57", "DHX8", "DHX9", "DIDO1", "DIMT1", "DIS3", "DKC1", "DLAT", "DLD", "DLG3", "DLGAP5", "DLST", "DNAAF5", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC13", "DNAJC2", "DNAJC7", "DNAJC8", "DNAJC9", "DNM1L", "DNM2", "DNMT1", "DNPH1", "DOCK7", "DOHH", "DOLPP1", "DPAGT1", "DPH5", "DPM1", "DPP3", "DPP9", "DPYSL2", "DPYSL5", "DSC3", "DSG2", "DSP", "DST", "DSTN", "DTYMK", "DUSP12", "DUSP9", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNC1LI2", "DYNLL2", "EARS2", "ECE1", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "ECSIT", "EDC4", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF2", "EFL1", "EFTUD2", "EHD1", "EHD4", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B5", "EIF2D", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF4B", "EIF4E", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAC2", "ELAVL1", "ELMO2", "ELMOD2", "ELOB", "ELOC", "ELP1", "ELP3", "EMC2", "EMG1", "ENAH", "ENO1", "ENO2", "ENOPH1", "EPHA7", "EPHX1", "EPHX2", "EPPK1", "EPRS", "EPS15L1", "ERAL1", "ERAP1", "ERC1", "ERCC2", "ERCC3", "ERH", "ERMP1", "ERO1A", "ERP29", "ESD", "ESPL1", "ETF1", "ETFA", "ETFB", "ETFDH", "ETNK1", "EWSR1", "EXO1", "EXOC3", "EXOC5", "EXOC6", "EXOC6B", "EXOC7", "EXOSC2", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC9", "EZR", "FAHD1", "FAM3C", "FAM98A", "FAM98B", "FARS2", "FARSA", "FARSB", "FBL", "FCGRT", "FDFT1", "FDPS", "FDXR", "FECH", "FEN1", "FH", "FKBP14", "FKBP1A", "FKBP3", "FKBP4", "FKBP5", "FKBP7", "FKBP8", "FLAD1", "FLII", "FMR1", "FN3KRP", "FNTA", "FNTB", "FOXRED1", "FSCN1", "FTL", "FTO", "FTSJ3", "FUBP1", "FUBP3", "FUCA1", "FUCA2", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GAK", "GALK1", "GALNT1", "GALNT2", "GALNT4", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GATAD2A", "GATAD2B", "GBE1", "GBF1", "GCAT", "GCC2", "GCDH", "GCLC", "GCN1", "GDI1", "GDI2", "GDPD1", "GFPT1", "GGH", "GINS2", "GLA", "GLB1", "GLDC", "GLMN", "GLO1", "GLRX3", "GLS", "GLT8D1", "GLUD1", "GLYR1", "GM2A", "GMFB", "GMPPB", "GMPS", "GNA13", "GNAI2", "GNAI3", "GNG12", "GNPAT", "GNPDA1", "GNS", "GOLGA2", "GOLGA3", "GOLT1B", "GOPC", "GOSR1", "GOT1", "GOT2", "GPAM", "GPAT4", "GPATCH4", "GPD2", "GPI", "GPKOW", "GPR107", "GPR89B", "GPT2", "GRHPR", "GRPEL1", "GRSF1", "GSPT1", "GSR", "GSS", "GSTK1", "GSTM3", "GTF2B", "GTF2E1", "GTF2F1", "GTF2I", "GTF3C1", "GTF3C3", "GTPBP1", "GTPBP3", "GUF1", "GYG1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACL1", "HADHB", "HAT1", "HBS1L", "HCCS", "HDGF", "HDGFL2", "HDHD2", "HDHD5", "HDLBP", "HEATR1", "HECTD1", "HEXA", "HEXB", "HIBADH", "HIBCH", "HINT2", "HINT3", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HM13", "HMBS", "HMGA1", "HMGCL", "HMGCR", "HMGN2", "HMOX1", "HMOX2", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPM", "HNRNPR", "HP1BP3", "HPRT1", "HS2ST1", "HSD17B10", "HSDL1", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPE1", "HTATSF1", "HTRA2", "HUS1", "HUWE1", "IARS", "IARS2", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDI1", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IK", "ILF2", "ILF3", "ILK", "ILKAP", "ILVBL", "IMP3", "IMP4", "IMPA1", "IMPAD1", "IMPDH1", "IMPDH2", "INTS11", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IQGAP2", "ISOC1", "ITCH", "ITGB1", "ITPA", "IVD", "KARS", "KAT7", "KCTD12", "KDELR1", "KDM1A", "KDM1B", "KDM3B", "KDSR", "KHDRBS1", "KHSRP", "KIAA0368", "KIF11", "KIF14", "KIF15", "KIF18B", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF4A", "KIF5B", "KIFC1", "KLC1", "KLC2", "KLC4", "KMT2A", "KPNA1", "KPNA2", "KPNA3", "KPNA6", "KPNB1", "KRR1", "L1RE1", "L2HGDH", "LAMP1", "LAMP2", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LBR", "LDAH", "LDHA", "LDHB", "LETM1", "LGMN", "LIG1", "LIG3", "LIMA1", "LIPA", "LMAN2", "LNPEP", "LONP1", "LPCAT1", "LPCAT3", "LPGAT1", "LRP1", "LRPAP1", "LRRC40", "LRRC47", "LRRC59", "LRWD1", "LSM2", "LSM3", "LSM4", "LSM6", "LSM7", "LSS", "LYAR", "LYPLA1", "LZTFL1", "M6PR", "MACF1", "MAGED2", "MAGT1", "MAN1A1", "MAP1B", "MAP1S", "MAP2K2", "MAPK1", "MAPK14", "MAPRE1", "MAPRE2", "MARCH5", "MARS", "MASTL", "MAT2A", "MAT2B", "MBOAT7", "MCCC1", "MCCC2", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCTS1", "MDH1", "MDH2", "ME1", "ME2", "MECP2", "MED21", "MED23", "MED24", "MED25", "METAP2", "METTL13", "METTL14", "METTL3", "METTL7A", "METTL7B", "MFSD3", "MFSD5", "MGEA5", "MGST2", "MGST3", "MIA2", "MIA3", "MICU1", "MICU2", "MIF", "MIPEP", "MKRN2", "MMAB", "MMS19", "MOB4", "MOGS", "MORF4L1", "MPG", "MPHOSPH10", "MPI", "MPP1", "MPP6", "MPRIP", "MPST", "MPV17", "MPV17L2", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL14", "MRPL15", "MRPL17", "MRPL19", "MRPL21", "MRPL22", "MRPL23", "MRPL24", "MRPL28", "MRPL3", "MRPL37", "MRPL38", "MRPL39", "MRPL40", "MRPL44", "MRPL45", "MRPL46", "MRPL50", "MRPL53", "MRPL55", "MRPL58", "MRPL9", "MRPS11", "MRPS15", "MRPS16", "MRPS18A", "MRPS22", "MRPS23", "MRPS25", "MRPS27", "MRPS30", "MRPS31", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRPS9", "MRRF", "MSH2", "MSH3", "MSH6", "MSMO1", "MSN", "MTA1", "MTA2", "MTAP", "MTCH1", "MTCH2", "MTMR14", "MTMR2", "MTOR", "MTPAP", "MUT", "MVK", "MYBBP1A", "MYCBP", "MYDGF", "MYEF2", "MYG1", "MYL6", "MYO1B", "MYO1C", "MYO1D", "MYO6", "NAA15", "NAA25", "NAA35", "NAA50", "NAE1", "NAGA", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NAPG", "NARS", "NASP", "NAT10", "NAXE", "NCAPD2", "NCAPD3", "NCBP1", "NCDN", "ND1", "NDUFA11", "NDUFA13", "NDUFA4", "NDUFA5", "NDUFA7", "NDUFA8", "NDUFA9", "NDUFAF2", "NDUFB1", "NDUFB10", "NDUFB3", "NDUFB4", "NDUFB5", "NDUFB6", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS6", "NDUFS7", "NDUFS8", "NDUFV1", "NDUFV2", "NECAP2", "NENF", "NGDN", "NHP2", "NIP7", "NKRF", "NKTR", "NLN", "NLRX1", "NME1", "NMT1", "NNT", "NOC4L", "NOL6", "NOL9", "NOM1", "NONO", "NOP14", "NOP56", "NOP58", "NOP9", "NPEPPS", "NPM1", "NRDC", "NSDHL", "NSF", "NSUN2", "NT5C2", "NT5C3B", "NT5DC1", "NT5DC2", "NTHL1", "NTMT1", "NTPCR", "NUCB1", "NUCB2", "NUDC", "NUDCD2", "NUDT1", "NUDT21", "NUDT5", "NUDT9", "NUF2", "NUMA1", "NUP107", "NUP153", "NUP155", "NUP160", "NUP210", "NUP214", "NUP37", "NUP50", "NUP54", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NXF1", "NXN", "OAT", "OCIAD1", "OCLN", "OCRL", "OGDH", "OGT", "OLA1", "OPA1", "OSGEP", "OTUB1", "OTUD4", "OTUD7B", "OXA1L", "OXCT1", "P3H1", "P3H4", "P4HA1", "P4HB", "PA2G4", "PABPN1", "PACSIN2", "PAFAH1B2", "PAFAH1B3", "PAIP1", "PAK1IP1", "PAK2", "PALLD", "PANK4", "PAPOLA", "PARG", "PARN", "PARP1", "PATL1", "PBK", "PBRM1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCK2", "PCMT1", "PCNA", "PCYOX1", "PDCD11", "PDCD5", "PDCD6", "PDCD6IP", "PDCL3", "PDE12", "PDE6D", "PDHA1", "PDHB", "PDIA3", "PDIA4", "PDIA5", "PDIA6", "PDK3", "PDLIM1", "PDLIM5", "PDLIM7", "PDPR", "PDS5A", "PDS5B", "PDXK", "PEBP1", "PECR", "PELO", "PEPD", "PES1", "PEX14", "PEX19", "PEX5", "PFDN2", "PFDN5", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGM3", "PGP", "PGRMC1", "PGRMC2", "PHAX", "PHC2", "PHF6", "PHGDH", "PHKA1", "PI4K2A", "PI4KB", "PICALM", "PIK3R4", "PINX1", "PIP4K2C", "PIR", "PISD", "PITHD1", "PITPNB", "PITRM1", "PKM", "PKMYT1", "PKN1", "PKN2", "PLA2G15", "PLAA", "PLBD2", "PLCG1", "PLD3", "PLD6", "PLEC", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLS3", "PM20D2", "PMPCA", "PMPCB", "PMVK", "PNP", "PNPLA6", "PNPT1", "PODXL", "POFUT1", "POGZ", "POLA1", "POLA2", "POLD1", "POLD2", "POLD3", "POLDIP3", "POLE", "POLE3", "POLE4", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2A", "POLR2B", "POLR2C", "POLR2D", "POLR2E", "POLR2F", "POLR2G", "POLR2L", "POLR3A", "POLR3C", "POLRMT", "POR", "PPA1", "PPA2", "PPAN", "PPAT", "PPIB", "PPIC", "PPID", "PPIF", "PPIH", "PPIL1", "PPIL3", "PPIL4", "PPM1G", "PPME1", "PPOX", "PPP1CA", "PPP1CB", "PPP1R10", "PPP1R12A", "PPP1R8", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP2R5E", "PPP3CA", "PPP4C", "PPP4R1", "PPP4R3A", "PPP5C", "PPP6C", "PPP6R3", "PPT1", "PPT2", "PPWD1", "PRAF2", "PRC1", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PREP", "PREPL", "PRIM1", "PRIM2", "PRKAA2", "PRKACA", "PRKAG1", "PRKAR1A", "PRKAR2A", "PRKCB", "PRKCSH", "PRKDC", "PRMT1", "PRMT3", "PRMT5", "PRMT9", "PRPF19", "PRPF31", "PRPF39", "PRPF4", "PRPF4B", "PRPF6", "PRPF8", "PRPSAP1", "PRPSAP2", "PRRC2A", "PRRC2C", "PRTFDC1", "PSAP", "PSAT1", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD7", "PSMD8", "PSMD9", "PSMG1", "PSPC1", "PTDSS1", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK7", "PTPA", "PTPN1", "PTPN11", "PTPRF", "PUDP", "PUF60", "PUM1", "PURA", "PWP1", "PXMP2", "PXN", "PYCR1", "PYCR2", "PYCR3", "PYGB", "PYGL", "QARS", "QKI", "QRSL1", "QSOX2", "QTRT2", "RAB3GAP1", "RAB3GAP2", "RABAC1", "RABGAP1", "RABL6", "RAC1", "RACGAP1", "RAD23A", "RAD23B", "RAE1", "RALA", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP6", "RANBP9", "RANGAP1", "RAP2B", "RAPGEF2", "RARS", "RARS2", "RAVER1", "RBBP6", "RBM12", "RBM14", "RBM17", "RBM19", "RBM22", "RBM26", "RBM27", "RBM34", "RBM4", "RCL1", "RCN1", "RCN2", "RDH11", "RDH13", "RDH14", "RDX", "RECQL", "REEP4", "REEP5", "REXO4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RHBDD2", "RHEB", "RHOG", "RHOT1", "RHOT2", "RIDA", "RIF1", "RNASEH2A", "RNF14", "ROCK1", "RPA1", "RPF1", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPN1", "RPN2", "RPP30", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS28", "RPS29", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RPUSD3", "RRBP1", "RRM1", "RRM2", "RRS1", "RSL1D1", "RSL24D1", "RSU1", "RTN4IP1", "S100A11", "S100A13", "SAAL1", "SACM1L", "SAE1", "SAMHD1", "SAP18", "SARM1", "SARS", "SARS2", "SART1", "SART3", "SBDS", "SCAF1", "SCAF4", "SCAMP1", "SCAMP2", "SCAMP3", "SCARB1", "SCARB2", "SCFD1", "SCML2", "SCO1", "SCO2", "SCP2", "SCPEP1", "SCRIB", "SDCBP", "SDF4", "SDHA", "SDHB", "SDR39U1", "SEC11A", "SEC23A", "SEC23B", "SEC23IP", "SEC24A", "SEC24B", "SEC24C", "SEC24D", "SEC31A", "SEC61A1", "SEC61B", "SEC61G", "SEC63", "SEH1L", "SENP3", "SEPHS1", "SEPT11", "SEPT2", "SEPT6", "SEPT7", "SEPT9", "SERBP1", "SERPINB6", "SERPINH1", "SET", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFXN1", "SFXN2", "SFXN4", "SHMT1", "SHMT2", "SIGMAR1", "SIN3A", "SKIV2L", "SKIV2L2", "SKP1", "SLC12A9", "SLC16A1", "SLC19A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A19", "SLC25A20", "SLC25A21", "SLC25A22", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A33", "SLC25A4", "SLC25A42", "SLC25A5", "SLC25A6", "SLC27A4", "SLC30A6", "SLC33A1", "SLC35B2", "SLC39A14", "SLC4A1AP", "SLC4A7", "SLC6A15", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCE1", "SMC6", "SMG5", "SMN1*", "SMNDC1", "SMPD4", "SMYD3", "SNAP23", "SNRNP200", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNW1", "SNX1", "SNX17", "SNX19", "SNX2", "SNX27", "SNX4", "SNX5", "SNX6", "SNX9", "SOAT1", "SOD2", "SON", "SORD", "SPAG9", "SPCS2", "SPEN", "SPHK2", "SPNS1", "SPR", "SPTLC1", "SPTLC2", "SQLE", "SREK1", "SRI", "SRM", "SRP14", "SRP54", "SRP68", "SRP9", "SRPK1", "SRPK2", "SRPRA", "SRPRB", "SRRM1", "SRSF1", "SRSF10", "SRSF11", "SRSF3", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSR1", "STAG1", "STAG2", "STAM", "STAMBP", "STAT1", "STAT3", "STK4", "STOM", "STOML2", "STRAP", "STRBP", "STT3A", "STT3B", "STX10", "STX12", "STX18", "STX3", "STX4", "STX5", "STX7", "STX8", "STXBP3", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGP2", "SUN1", "SUN2", "SUPT16H", "SUPT6H", "SUPV3L1", "SURF4", "SURF6", "SUZ12", "SYNCRIP", "SYNGR2", "SYNJ2BP", "SYS1", "TAB1", "TADA3", "TAF15", "TAF6L", "TAGLN2", "TALDO1", "TAOK1", "TAP1", "TARS", "TARS2", "TBC1D13", "TBC1D15", "TBC1D2B", "TBC1D4", "TBC1D9B", "TBCA", "TBCB", "TBCD", "TBCE", "TBL3", "TCEA1", "TCERG1", "TCOF1", "TCP1", "TDRKH", "TECR", "TERF2IP", "TES", "TFB1M", "TFCP2", "TFG", "TFIP11", "TFRC", "TGOLN2", "THOC1", "THOC2", "THOC3", "THOP1", "THRAP3", "THUMPD3", "TIA1", "TIAL1", "TIGAR", "TIMM10", "TIMM10B", "TIMM17A", "TIMM17B", "TIMM23", "TIMM44", "TIMM9", "TJP1", "TK1", "TKT", "TM9SF2", "TM9SF3", "TM9SF4", "TMED10", "TMED2", "TMED4", "TMED5", "TMED7", "TMED9", "TMEM259", "TMEM38B", "TMEM87A", "TMOD1", "TMOD3", "TMPO", "TMX2", "TMX3", "TNPO1", "TNPO2", "TNPO3", "TOE1", "TOMM20", "TOMM22", "TOMM40", "TOMM5", "TOMM70", "TOP1", "TOP2A", "TOP2B", "TOR1B", "TOR3A", "TP53", "TPI1", "TPM1", "TPM3", "TPM4", "TPP1", "TPP2", "TPR", "TPT1", "TPX2", "TRAF2", "TRAP1", "TRIM21", "TRIM33", "TRIP12", "TRIP13", "TRIR", "TRMT10C", "TRMT11", "TRMT1L", "TRMT2A", "TRMU", "TROVE2", "TRRAP", "TRUB1", "TSFM", "TSG101", "TST", "TTK", "TTYH3", "TUBB", "TUBB2A", "TUBB2B", "TUBB3", "TUBB4B", "TUBB6", "TUBGCP2", "TUBGCP3", "TUBGCP4", "TUFM", "TWF1", "TWF2", "TWISTNB", "TWNK", "TXLNA", "TXLNG", "TXNDC12", "TXNDC17", "TXNDC5", "TXNDC9", "TXNL1", "TXNRD1", "TYMS", "U2AF1", "U2SURP", "UBA1", "UBA2", 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sha256:35fc27aebf1a0899dbbc2e538e1f42a31b59ea0182c25d49ceb45516648a7008 +size 138388 diff --git a/pharos_dto/basic/plot_6.png b/pharos_dto/basic/plot_6.png new file mode 100644 index 0000000000000000000000000000000000000000..0c014f00f310d8020a1bc3a305c60be6ffce0a24 --- /dev/null +++ b/pharos_dto/basic/plot_6.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:226caada4da036f2868683d67e7f686d51df03af6122fe3f13d0816bc80cf56b +size 138305 diff --git a/pharos_dto/basic/plot_7.png b/pharos_dto/basic/plot_7.png new file mode 100644 index 0000000000000000000000000000000000000000..2b512bcddda7ff11d73c4c4c514b95bff09a84f4 --- /dev/null +++ b/pharos_dto/basic/plot_7.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:4205377dc30bbb8e657d3de55f3c64d743c86acf30d57e27346b986042288dd7 +size 132146 diff --git a/pharos_dto/basic/plot_8.png b/pharos_dto/basic/plot_8.png new file mode 100644 index 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sha256:95d0a1ab13d2f5ad731bc51a2ea6b7622939415568332a76f969cd3a93e2780f +size 321534 diff --git a/pharos_dto/df_merge.tsv b/pharos_dto/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..c21d81b9e9cea0a5c11fcba33225accaaab1a051 --- /dev/null +++ b/pharos_dto/df_merge.tsv @@ -0,0 +1,14 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +SLC superfamily of solute carriers 39 46 4.604896118558827 4.12671806193643e-06 18.888349514563107 44.33009708737864 2.1618907004737498 0.1690913715307362 9.633686860107934 5.825351940723624 1.7350998035598977 0.2760301582542676 6.201457971654613e-08 0.0017316031059745 0.007702425165207 2.989598852305968e-07 1.133048215062548e-07 +SLC25 family of mitochondrial transporters 22 23 3.857387164934564 0.0001146055556109 9.148058252427184 20.71359223300971 2.0411027534642088 0.1411881998864352 5.368907349966936 1.8276489510009888 1.309103123363054 0.2428184236965967 1.6461520437918124e-12 0.0007225305704933 0.0003996291666218 9.351458506116467e-09 2.581378883513759e-12 +Receptor 10 28 3.212142698626804 0.0013174891706171 8.25242718446602 27.344660194174757 1.739519175745715 0.1905542238199536 2.855648283399814 4.245230977176689 1.1861053756197322 0.2707159726336181 0.0093669622876555 1.0 0.2673507529215621 0.0009143949426363 0.0115162515727426 +Transporter 97 189 2.9098422899903493 0.0036161117699129 57.59466019417476 188.27912621359224 1.4971900036635353 0.4160578104205245 21.77919356765414 18.57070590158326 1.926868489654782 0.421013047757716 1.4571625358018914e-13 0.0082689013210767 1.2955680496139524e-05 1.5293859635681473e-07 1.689452500003174e-13 +Mitochondrial nucleotide transporter subfamily 9 10 2.8765809082872127 0.0040200912089547 4.216019417475728 9.065533980582524 1.5870110662923598 0.1668197633609344 2.720728714423222 1.1029864386277723 1.1616247375257451 0.2431804664231326 3.3424889089260983e-09 0.0022827689145391 0.0086772133501052 1.7866814760971125e-05 4.3317336350771446e-09 +Glycosyltransferase 7 18 2.6078506599229696 0.009111269535196 5.713592233009709 16.264563106796118 0.58827010515732 0.444796659838118 2.8207810163966904 2.842193627279741 1.1276277753027448 0.3350616775048655 0.0079112921611303 1.0 0.453417077782931 0.0036882952947036 0.0093715763041592 +Calcium-binding protein 8 18 2.599214377695382 0.0093437400242204 6.135922330097087 18.021844660194176 1.3650952896045327 0.2072953623045914 2.3371152398743247 2.2037057261181348 1.237653756718734 0.2545563939054063 0.0010526443805106 0.1991580424676108 0.0707844675435839 0.0231788170721074 0.0012725492286288 +Calmodulin 7 15 2.5665691864215385 0.0102710132987609 5.330097087378641 14.50728155339806 1.3338669185027796 0.2094989649985028 2.1356354617596836 1.8597539737980884 1.176586593960994 0.2465515447823433 0.0005144971349197 0.1430638950507344 0.2638774705145789 0.0394981797992919 0.0006137659201312 +Intracellular calcium-sensing protein 7 15 2.5665691864215385 0.0102710132987609 5.330097087378641 14.50728155339806 1.3338669185027796 0.2094989649985028 2.1356354617596836 1.8597539737980884 1.176586593960994 0.2465515447823433 0.0005144971349197 0.1430638950507344 0.2638774705145789 0.0394981797992919 0.0006137659201312 +SNARE protein 7 11 2.489987327893528 0.0127747650012925 4.555825242718447 10.6626213592233 0.9494792984446184 0.3117420251981136 2.5225757464631977 2.583604188764985 1.1633177546874711 0.3031193116521645 0.0335087685255396 1.0 0.0269433955752302 0.133861047002827 0.0367673926038443 +Oxidase 5 18 2.3276077943902145 0.0199329391911831 6.703883495145631 19.237864077669904 1.0247065178117305 0.263154064152295 3.1321515397534676 1.9967748999180144 1.3264616190823058 0.2799417791483025 0.000627516181514 0.0005142462303242 0.0037031463805551 0.0001086836009891 0.0007476891257379 +F-type and V-type ATPases 5 16 2.057961994770405 0.0395937818033469 4.995145631067961 15.616504854368932 0.6819760311565471 0.3553057475304781 2.5561606009064737 1.187932616128487 1.149561543758102 0.2999604229905949 0.0195192259352808 0.1049896535105009 0.0199028792923938 0.0164697860130212 0.0215080214882775 +Mitochondrial amino acid transporter subfamily 5 6 2.00279806637636 0.0451989675075981 1.75 5.106796116504855 1.5314439851709 0.1644824524943633 1.357512359363716 0.7195281808878056 0.8276270779181836 0.2049815877367878 0.0491741335464076 1.0 0.073646168181401 0.174886929038293 0.0518681859770243 diff --git a/pharos_dto/metrics.json b/pharos_dto/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..0e66c9e8ceb93d57d717d86560fb1ea4cd254518 --- /dev/null +++ b/pharos_dto/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2974, + "annotations_size": 1919, + "title": "Average number of proteins per term", + "value": 3.112558624283481 +} \ No newline at end of file diff --git a/pharos_dto/paths.json b/pharos_dto/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..3d3d003fa9fa09f942a3e0cd330a9aac4f82a7d1 --- /dev/null +++ b/pharos_dto/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/pharos_dto/fragment/C220/C220_val_log2fc"} \ No newline at end of file diff --git a/pharos_dto/result.tsv b/pharos_dto/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..e9ccc8609468e6b657ac42c03d1d08b9c5c52113 --- /dev/null +++ b/pharos_dto/result.tsv @@ -0,0 +1,61 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +SLC superfamily of solute carriers 0.7297261189794071 4.604896118558827 4.12671806193643e-06 0.0078879141391023 0.0079191719608579 46 Q9HC21,O00400,Q9UJS0,Q9H0U3,P41440,Q70HW3,Q8IXU6,Q9UBX3,P05141,Q9H2J7,O43772,Q9NZJ7,Q7L0J3,Q6NXT4,Q96NB2,Q9HC07,Q9H2D1,Q00325,Q9H936,Q8TAD4,Q9Y6C9,Q02978,Q9BQT8,P53985,P12236,Q9Y6M7,Q9Y619,O75746,Q9BSK2,O95202,Q15043,Q86VD7,Q6NUK1,Q8TB61,O43808,Q15758,P12235,Q9H9B4,P53007 39 +SLC25 family of mitochondrial transporters 0.7587258556421699 3.857387164934564 0.0001146055556109 0.1974335829064149 0.0882925422521662 23 Q9HC21,Q9UJS0,Q70HW3,Q9UBX3,P05141,O43772,Q9NZJ7,Q9H2D1,Q00325,Q9H936,Q9Y6C9,Q02978,Q9BQT8,P12236,Q9Y619,O75746,Q9BSK2,Q86VD7,Q6NUK1,O43808,P12235,P53007 22 +Receptor 0.6298071297520809 3.2121426986268036 0.0013174891706171 0.9203352967493652 0.0882925422521662 28 Q567V2,Q9NR77,Q6NTF9,Q14108,Q9GZP9,P57105,Q13432,A6NIH7,Q8WTV0,Q9BUN8 10 +Transporter 0.5465019735226522 2.9098422899903493 0.0036161117699129 0.9990431802097072 0.0882925422521662 189 P41440,O43493,Q70HW3,P13473,Q8IXU6,Q9UBX3,Q9UI14,Q9P253,P20020,P24390,P00846,Q6NXT4,Q96NB2,Q9HC07,Q9H2D1,Q9H936,O60499,P49755,P61421,Q15070,Q92544,Q9HD45,Q9P2W9,O15400,Q9BQE5,Q8N2H4,Q96ES6,Q9Y619,O95249,O75746,Q93050,Q9BSK2,Q15758,P12235,Q9H9B4,P28288,O43760,Q12907,O00400,O00560,Q03518,O43772,Q9NZJ7,Q8N1B4,P17900,Q8TAD4,Q9Y6C9,P50542,Q02978,Q9BQT8,P24539,P53985,P12236,Q9Y6M7,Q9BVK6,Q8TBP6,P06576,Q12768,O95202,Q15043,Q8TB61,Q9Y5J6,Q92973,Q15363,Q9HC21,Q9UJS0,P05023,P05141,Q9H2J7,Q9H6H4,O00505,Q7L0J3,Q00325,P33527,P11279,Q99805,Q9Y487,P16615,Q13190,O75027,Q9Y3B3,Q86VD7,Q6NUK1,P35670,Q9H0U3,Q00765,P52292,O96008,P51572,P08183,Q12846,Q9UNK0,Q15388,P56385,Q86Y82,O43808,P53007 97 +Mitochondrial nucleotide transporter subfamily 0.8353576248313201 2.8765809082872127 0.0040200912089547 0.9995606012846966 0.0882925422521662 10 Q9BSK2,Q9HC21,Q9H2D1,P12236,Q6NUK1,Q86VD7,P12235,Q70HW3,P05141 9 +Glycosyltransferase 0.62833531056864 2.6078506599229696 0.009111269535196 0.9999999764623956 0.0882925422521662 18 P46977,Q8N4A0,Q9H3H5,Q8N128,Q9BV10,Q9BT22,Q16739 7 +Calcium-binding protein 0.6270390186862085 2.599214377695382 0.0093437400242204 0.999999984995748 0.0882925422521662 18 O43852,Q02818,Q8IYU8,Q99584,Q9BRK5,Q14257,P43307,P80303 8 +Calmodulin 0.6719617817296448 2.5665691864215385 0.0102710132987609 0.9999999975125164 0.0882925422521662 15 O43852,Q02818,Q8IYU8,Q99584,Q9BRK5,Q14257,P80303 7 +Intracellular calcium-sensing protein 0.6719617817296448 2.5665691864215385 0.0102710132987609 0.9999999975125164 0.0882925422521662 15 O43852,Q02818,Q8IYU8,Q99584,Q9BRK5,Q14257,P80303 7 +SNARE protein 0.7212467207555078 2.489987327893528 0.0127747650012925 0.9999999999807344 0.0882925422521662 11 Q12846,Q9P2W9,O15400,Q86Y82,Q13190,O60499,Q9UNK0 7 +Oxidase 0.5869376017568256 2.3276077943902145 0.0199329391911831 1.0 0.0989500098247225 18 O43169,O15260,P14406,Q15800,O43819 5 +F-type and V-type ATPases 0.577038802032354 2.057961994770405 0.0395937818033469 1.0 0.1337684283109556 16 Q93050,P24539,P00846,Q9Y487,P56385 5 +Mitochondrial amino acid transporter subfamily 0.7543800539083431 2.00279806637636 0.0451989675075981 1.0 0.1433717300810379 6 Q9UJS0,O43772,Q9H936,Q9Y619,O75746 5 +ATP-binding cassette transporter family 0.7878073425395749 1.9309641692697916 0.053487483608904 1.0 0.1593827345426816 5 P08183,O75027,Q03518,P33527 4 +Signaling 0.5109587038585722 1.8930953479175687 0.0583451907290479 1.0 0.1681147462598244 19 O15173,Q07820,P43490,Q8IZ81,Q96PC5,Q8WUJ1,O00264 7 +P-type ATPases 0.7219488012136478 1.8491988028307351 0.0644291115481738 1.0 0.1783042723298524 6 P35670,P05023,P16615 3 +Esterase 0.6286891194609198 1.798871000001602 0.0720390889074742 1.0 0.1896524896976515 10 P49327,Q9UMR5,Q969T7,P50897 4 +Membrane trafficking regulatory protein 0.5127101656858151 1.706894991048265 0.0878415720010754 1.0 0.2141905675604368 17 P11279,P24390,O43760,Q96EE3,Q8WVM8,P13473,O00560,Q9P253,P50542 9 +SLC30 zinc transporter family 0.9377523553162888 1.7012464818771558 0.0888967128749222 1.0 0.2148523828803222 2 Q6NXT4 1 +Ion channel 0.6106224596063999 1.6981299421861784 0.0894832394595632 1.0 0.2150511078112027 10 Q4KMQ2,Q9C0H2,P51798,Q96S66,P51790 5 +Miscellaneous SLC25 mitochondrial transporters 0.9364064602960976 1.6955382767653715 0.0899733554819262 1.0 0.2152853730296962 2 Q9NZJ7 1 +Oxygenase 0.7313522283415703 1.6733959107278915 0.0942493823455654 1.0 0.2219197113142823 5 Q14534 1 +Methyltransferase 0.5265738689257297 1.564760622049021 0.1176390481073046 1.0 0.256242149055525 14 Q9BV86,Q9H8H3 2 +Mitochondrial di- and tri-carboxylic acid transporter subfamily 0.7643097643097787 1.5448368021456622 0.122385743023448 1.0 0.2612438719265816 4 Q9BQT8,Q9UBX3,P53007 3 +Reductase 0.506333807716227 1.500233750998364 0.1335538634176123 1.0 0.2764723450899655 15 O95881,O95168,Q15392,Q9UBM7,P00374,Q9UDW1,Q14739 7 +Acyltransferase 0.5862984740226594 1.413296996323801 0.1575684168011986 1.0 0.3057368977163803 9 P49354,Q8NF37 2 +F-type ATPase 0.608673043854663 1.39781363276922 0.1621690394351769 1.0 0.3112288860145499 8 P24539,P00846 2 +ABCB subfamily 0.8498821945472824 1.301428130710922 0.19311194992882 1.0 0.3499356297577013 3 O75027,Q03518 2 +Lipid kinase 0.6999922010495043 1.2625587866569603 0.2067477870078984 1.0 0.3616672773638624 4 Q9UBF8 1 +Lyase 0.4506067199036775 1.2568486063605884 0.2088084614779564 1.0 0.3636135656292703 17 A1L0T0,O96005,Q96KA5,P53701 4 +SLC35 family of nucleotide sugar transporters 0.8196500672947575 1.1993881918223128 0.2303770369055606 1.0 0.3834771525105137 2 Q8TB61 1 +V-type ATPase 0.5700932612834867 1.1963828741460556 0.2315471813690535 1.0 0.3847419944697814 8 Q93050,Q9Y487 2 +Chloride channel family 0.8176312247644686 1.1908655333989835 0.233706377113138 1.0 0.3866228773104412 2 P51798 1 +Ca2+-ATPases 0.8166218034993311 1.1866061013952691 0.2353830281220525 1.0 0.3883921160500592 2 P16615 1 +SLC56 Sideroflexins 0.7883580080753699 1.0679652088427047 0.2855362057960002 1.0 0.4366087481454378 2 Q96NB2 1 +RSK subfamily 0.7678331090174999 0.982796385323028 0.3257076612438938 1.0 0.4749490896102069 2 P51812 1 +RSK family 0.7678331090174999 0.982796385323028 0.3257076612438938 1.0 0.4749490896102069 2 P51812 1 +Methyl-lysine/arginine binding protein 0.6320010107565999 0.9640411588289238 0.335025291066032 1.0 0.4833715175198141 4 P83916,Q16637 2 +Phosphatase inhibitor 0.566784824028578 0.901570761149036 0.3672849288714879 1.0 0.510738969930714 5 Q01105,P55209 2 +Oxidoreductase 0.330255308752304 0.8448929757834398 0.398170596650216 1.0 0.5358266772572698 109 O43169,P14406,Q8N0U8,P09622,Q15800,Q9NZ01,P00403,Q13423,Q9UDW1,Q9H9P8,O15260,Q9Y6M9,O95831,O75438,Q14534,Q14739,Q16850,Q9UBM7,Q15392,Q96CU9,Q9P0J0,O15254,O95881,Q8N4Q0,P51649,Q9BY49,P21912,O43819,P03886,Q15067,O75880,O95168,P00374 33 +Phosphatase modulator 0.4829361498131913 0.7042690986000739 0.4812652065253915 1.0 0.5993172818444038 7 Q01105,P55209 2 +Metalloprotease 0.3253616073365892 0.6837083955942056 0.4941593209204862 1.0 0.6060894546182335 37 Q9NZ08,P42892,Q5JRX3,Q9UIQ6,P55786,P31930,O75844,P02786,Q99797,Q96TA2,Q10713,Q9BYT8,P22695 13 +Na+/K+-ATPases 0.6855726584278687 0.664323031587414 0.5064835831732615 1.0 0.6124398211149897 3 P05023 1 +SET domain 0.6584791386271902 0.5569031612449129 0.5775935946382376 1.0 0.6625236749018397 2 Q9H7B4 1 +Extracellular structure 0.4420379372092142 0.5321251601105668 0.5946393125588303 1.0 0.6740237125264704 8 O75718,Q92791 2 +Phospholipase 0.5216319159212611 0.5036792793386067 0.6144867714343187 1.0 0.6883830206552585 4 Q8N2A8 1 +Protease inhibitor 0.4030554088019802 0.4191050348183979 0.6751393712488081 1.0 0.7237946667186943 9 Q06481,Q9UJZ1,P05067,P27105 4 +Transferase 0.3022887892343013 0.2944369896123108 0.768424005289527 1.0 0.7839477225681033 127 O15269,P35610,P49354,Q9H3H5,Q13126,P46977,Q8N4A0,Q9H8H3,Q9BT22,P23786,Q8NCH0,Q9BV86,O15127,Q9BV10,Q16739,Q8NF37,Q9BWD1,Q8N128,P21964,Q96N66 20 +Chromodomain 0.5693966675804736 0.2876071315805838 0.7736474852342303 1.0 0.7888573454646589 3 P83916 1 +Extracellular matrix glycoprotein 0.4565656565656418 0.2718067664211245 0.7857706021825419 1.0 0.7999436528319883 4 Q96CW1,Q9Y2T2,Q32P28 3 +Lipase 0.4180643262254362 0.2646341530116829 0.7912913075214805 1.0 0.8051368076000641 5 Q8N2A8 1 +Protein methyltransferase 0.3834231805929941 0.2308661394734689 0.8174187969458879 1.0 0.830840397955063 6 O60678,O14744,Q9H7B4,O96028,Q86X55 5 +Serine protease 0.2844399080973326 0.2263781378464268 0.8209073300769485 1.0 0.8339445031326967 27 Q9H3G5,P42785,O14773,P10619,Q96I24,Q86UT6,P67812,Q8N2K0,Q9HB40 9 +CDK4 subfamily 0.5222072678331211 0.1684372325631863 0.8662393191643454 1.0 0.8772101601458464 2 P11802 1 +Other group 0.3090172239108367 0.1324449140153552 0.8946323913105401 1.0 0.9050076747100296 13 Q8TD19,O00311,Q96GD4,P19525,Q6PHR2,Q96KB5,O14976,P33981,P53350,O14965,O60566,Q99640 12 +Small GTPase 0.2707556760420191 0.1015115901969597 0.919144357439358 1.0 0.9293140263045984 23 Q8IXI1,Q15019,Q96P70,Q9UI26,O95373,Q9NVA2,Q16181,P60953,Q8IXI2,Q15382,O00429,O15397,P11233,Q14141,P50570,O60313,P61225,P63000,O75616,P62826,P55060,P84095 22 +DNA glycosylase 0.3845895020188381 0.0191079854388658 0.9847549611349284 1.0 0.9935566616287738 2 P29372 1 +Glycosylase 0.3845895020188381 0.0191079854388658 0.9847549611349284 1.0 0.9935566616287738 2 P29372 1 +Carbohydrate kinase 0.3606998654105049 0.0119836820097323 0.9904386339925306 1.0 0.9977174481006122 2 P19367 1 +CAMK group 0.3283084682919605 0.01101273263533 0.9912132882675226 1.0 0.9977827850715416 5 Q14012 1 diff --git a/pharos_dto/selections.json b/pharos_dto/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..696d97bf46212f1f56724fbee76bbbb82adef849 --- /dev/null +++ b/pharos_dto/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase", "1,4-alpha-glucan-branching enzyme", "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1", "10 kDa heat shock protein, mitochondrial", "116 kDa U5 small nuclear ribonucleoprotein component", "14-3-3 protein beta/alpha", "14-3-3 protein epsilon", "14-3-3 protein eta", "14-3-3 protein gamma", "14-3-3 protein theta", "14-3-3 protein zeta/delta", "2',3'-cyclic-nucleotide 3'-phosphodiesterase", "2',5'-phosphodiesterase 12", "2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial", "2-hydroxyacyl-CoA lyase 1", "26S proteasome non-ATPase regulatory subunit 1", "26S proteasome non-ATPase regulatory subunit 12", "26S proteasome non-ATPase regulatory subunit 13", "26S proteasome non-ATPase regulatory subunit 14", "26S proteasome non-ATPase regulatory subunit 2", "26S proteasome non-ATPase regulatory subunit 3", "26S proteasome non-ATPase regulatory subunit 4", "26S proteasome non-ATPase regulatory subunit 7", "26S proteasome non-ATPase regulatory subunit 8", "26S proteasome non-ATPase regulatory subunit 9", "26S proteasome regulatory subunit 10B", "26S proteasome regulatory subunit 4", "26S proteasome regulatory subunit 6A", "26S proteasome regulatory subunit 6B", "26S proteasome regulatory subunit 7", "26S proteasome regulatory subunit 8", "28S ribosomal protein S11, mitochondrial", "28S ribosomal protein S16, mitochondrial", "28S ribosomal protein S27, mitochondrial", "28S ribosomal protein S29, mitochondrial", "28S ribosomal protein S35, mitochondrial", "28S ribosomal protein S5, mitochondrial", "28S ribosomal protein S7, mitochondrial", "3'(2'),5'-bisphosphate nucleotidase 1", "3-hydroxyacyl-CoA dehydrogenase type-2", "3-hydroxyisobutyrate dehydrogenase, mitochondrial", "3-hydroxyisobutyryl-CoA hydrolase, mitochondrial", "3-ketoacyl-CoA thiolase, mitochondrial", "3-mercaptopyruvate sulfurtransferase", "39S ribosomal protein L1, mitochondrial", "39S ribosomal protein L11, mitochondrial", "39S ribosomal protein L12, mitochondrial", "39S ribosomal protein L14, mitochondrial", "39S ribosomal protein L17, mitochondrial", "39S ribosomal protein L19, mitochondrial", "39S ribosomal protein L21, mitochondrial", "39S ribosomal protein L22, mitochondrial", "39S ribosomal protein L23, mitochondrial", "39S ribosomal protein L24, mitochondrial", "39S ribosomal protein L38, mitochondrial", "39S ribosomal protein L39, mitochondrial", "39S ribosomal protein L44, mitochondrial", "39S ribosomal protein L9, mitochondrial", "39S ribosomal protein S18a, mitochondrial", "4-trimethylaminobutyraldehyde dehydrogenase", "40S ribosomal protein S10", "40S ribosomal protein S11", "40S ribosomal protein S12", "40S ribosomal protein S13", "40S ribosomal protein S14", "40S ribosomal protein S15a", "40S ribosomal protein S17", "40S ribosomal protein S18", "40S ribosomal protein S19", "40S ribosomal protein S2", "40S ribosomal protein S20", "40S ribosomal protein S21", "40S ribosomal protein S23", "40S ribosomal protein S24", "40S ribosomal protein S28", "40S ribosomal protein S3", "40S ribosomal protein S3a", "40S ribosomal protein S4, X isoform", "40S ribosomal protein S5", "40S ribosomal protein S6", "40S ribosomal protein S7", "40S ribosomal protein S8", "40S ribosomal protein S9", "40S ribosomal protein SA", "45 kDa calcium-binding protein", "4F2 cell-surface antigen heavy chain", "5'-AMP-activated protein kinase catalytic subunit alpha-2", "5'-AMP-activated protein kinase subunit gamma-1", "5'-nucleotidase domain-containing protein 1", "5'-nucleotidase domain-containing protein 2", "55 kDa erythrocyte membrane protein", "6-phosphogluconate dehydrogenase, decarboxylating", "6-phosphogluconolactonase", "60 kDa SS-A/Ro ribonucleoprotein", "60S ribosomal protein L10", "60S ribosomal protein L10a", "60S ribosomal protein L11", "60S ribosomal protein L12", "60S ribosomal protein L13", "60S ribosomal protein L13a", "60S ribosomal protein L14", "60S ribosomal protein L15", "60S ribosomal protein L18", "60S ribosomal protein L19", "60S ribosomal protein L21", "60S ribosomal protein L22", "60S ribosomal protein L23", "60S ribosomal protein L23a", "60S ribosomal protein L24", "60S ribosomal protein L26", "60S ribosomal protein L27", "60S ribosomal protein L27a", "60S ribosomal protein L28", "60S ribosomal protein L29", "60S ribosomal protein L3", "60S ribosomal protein L30", "60S ribosomal protein L31", "60S ribosomal protein L32", "60S ribosomal protein L35", "60S ribosomal protein L35a", "60S ribosomal protein L36", "60S ribosomal protein L36a", "60S ribosomal protein L37", "60S ribosomal protein L38", "60S ribosomal protein L5", "60S ribosomal protein L6", "60S ribosomal protein L7", "60S ribosomal protein L7-like 1", "60S ribosomal protein L7a", "60S ribosomal protein L8", "60S ribosomal protein L9", "7,8-dihydro-8-oxoguanine triphosphatase", "7-dehydrocholesterol reductase", "7-methylguanosine phosphate-specific 5'-nucleotidase", "ABCB subfamily", "ABCC subfamily", "ABCD subfamily of peroxisomal ABC transporters", "ADP-dependent glucokinase", "ADP-ribose pyrophosphatase, mitochondrial", "ADP-sugar pyrophosphatase", "ADP/ATP translocase 1", "ADP/ATP translocase 2", "ADP/ATP translocase 3", "AFG3-like protein 2", "AGC group", "AH receptor-interacting protein", "AK1 subfamily", "AK2 subfamily", "AKT family", "AMPK subfamily", "AP-1 complex subunit beta-1", "AP-1 complex subunit gamma-1", "AP-1 complex subunit mu-1", "AP-1 complex subunit sigma-2", "AP-2 complex subunit alpha-1", "AP-2 complex subunit alpha-2", "AP-2 complex subunit beta", "AP-2 complex subunit mu", "AP-2 complex subunit sigma", "AP-3 complex subunit beta-1", "AP-3 complex subunit delta-1", "AP-3 complex subunit mu-1", "AP-3 complex subunit sigma-1", "AT-rich interactive domain-containing protein 3B", "ATP synthase F(0) complex subunit B1, mitochondrial", "ATP synthase mitochondrial F1 complex assembly factor 1", "ATP synthase subunit a", "ATP synthase subunit alpha, mitochondrial", "ATP synthase subunit beta, mitochondrial", "ATP synthase subunit d, mitochondrial", "ATP synthase subunit e, mitochondrial", "ATP synthase subunit f, mitochondrial", "ATP synthase subunit gamma, mitochondrial", "ATP-binding cassette sub-family B member 7, mitochondrial", "ATP-binding cassette sub-family D member 3", "ATP-binding cassette sub-family F member 1", "ATP-binding cassette sub-family F member 2", "ATP-binding cassette sub-family F member 3", "ATP-binding cassette transporter family", "ATP-citrate synthase", "ATP-dependent 6-phosphofructokinase, muscle type", "ATP-dependent 6-phosphofructokinase, platelet type", "ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial", "ATP-dependent DNA helicase Q1", "ATP-dependent PFK group I subfamily", "ATP-dependent RNA helicase A", "ATP-dependent RNA helicase DHX29", "ATP-dependent RNA helicase DHX8", "ATP-dependent zinc metalloprotease YME1L1", "ATPase ASNA1", "ATPase family AAA domain-containing protein 2", "ATPase family AAA domain-containing protein 3A", "ATPase family AAA domain-containing protein 3B", "ATPase inhibitor, mitochondrial", "AUR family", "Abl interactor 1", "Acetolactate synthase-like protein", "Acetyl-CoA acetyltransferase, cytosolic", "Acetyl-CoA acetyltransferase, mitochondrial", "Acetyl-coenzyme A transporter 1", "Acetyltransferase", "Acid ceramidase", "Acidic leucine-rich nuclear phosphoprotein 32 family member B", "Acidic leucine-rich nuclear phosphoprotein 32 family member E", "Aconitate hydratase, mitochondrial", "Actin and actin related protein", "Actin binding motor protein", "Actin family cytoskeletal protein", "Actin-like protein 6A", "Actin-related protein 10", "Actin-related protein 2", "Actin-related protein 2/3 complex subunit 1A", "Actin-related protein 2/3 complex subunit 3", "Actin-related protein 2/3 complex subunit 4", "Actin-related protein 2/3 complex subunit 5", "Actin-related protein 3", "Acyl-CoA dehydrogenase family member 11", "Acyl-CoA dehydrogenase family member 9, mitochondrial", "Acyl-CoA synthetase family member 3, mitochondrial", "Acyl-CoA-binding domain-containing protein 5", "Acyl-coenzyme A thioesterase 9, mitochondrial", "Acylamino-acid-releasing enzyme", "Acylpyruvase FAHD1, mitochondrial", "Acyltransferase", "Adenosine 3'-phospho 5'-phosphosulfate transporter 1", "Adenosylhomocysteinase", "Adenylate kinase 2, mitochondrial", "Adenylate kinase family", "Adenylate kinase isoenzyme 1", "Adenylosuccinate lyase", "Adenylosuccinate synthetase isozyme 2", "Adenylyl cyclase-associated protein 1", "Afadin", "Aflatoxin B1 aldehyde reductase member 2", "Alanine aminotransferase 2", "Alanine--tRNA ligase, cytoplasmic", "Alanine--tRNA ligase, mitochondrial", "Alanine/serine/cysteine transporter subfamily", "Alcohol dehydrogenase [NADP(+)]", "Alcohol dehydrogenase class-3", "Aldehyde dehydrogenase X, mitochondrial", "Aldehyde dehydrogenase, mitochondrial", "Aldose reductase", "Alpha-adducin", "Alpha-aminoadipic semialdehyde dehydrogenase", "Alpha-centractin", "Alpha-enolase", "Alpha-globin transcription factor CP2", "Alpha-soluble NSF attachment protein", "Alpha-taxilin", "Amidophosphoribosyltransferase", "Aminoacyl tRNA synthase complex-interacting multifunctional protein 1", "Aminoacyl-tRNA synthetase", "Amylase", "Amyloid-beta A4 protein", "Amyloid-like protein 2", "Anaphase-promoting complex subunit 1", "Ancient ubiquitous protein 1", "Anion channel tweety (tweety) family", "Annexin", "Anoctamin-6", "Antibacterial response protein", "Antigen peptide transporter 1", "Apolipoprotein", "Apolipoprotein L2", "Apoptosis-inducing factor 1, mitochondrial", "Arfaptin-1", "Arfaptin-2", "Asparagine synthetase [glutamine-hydrolyzing]", "Asparagine--tRNA ligase, cytoplasmic", "Aspartate--tRNA ligase, cytoplasmic", "Aspartate--tRNA ligase, mitochondrial", "Aspartic protease", "Ataxin-2-like protein", "Atlastin-2", "Atp-dependent 6-phosphofructokinase, liver type", "Atypical SLC22B subfamily", "Atypical group", "Aurora kinase a", "Aurora kinase b", "B-cell receptor-associated protein 31", "BTB/POZ domain-containing protein KCTD12", "BUB family", "BUB3-interacting and GLEBS motif-containing protein ZNF207", "Basic leucine zipper and W2 domain-containing protein 1", "Basic leucine zipper and W2 domain-containing protein 2", "Bcl-2 homologous antagonist/killer", "Bcl-2-associated transcription factor 1", "Beta-centractin", "Beta-galactosidase", "Beta-hexosaminidase subunit alpha", "Beta-hexosaminidase subunit beta", "Bifunctional coenzyme A synthase", "Bifunctional epoxide hydrolase 2", "Bifunctional glutamate/proline--tRNA ligase", "Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial", "Bifunctional purine biosynthesis protein PURH", "Biliverdin reductase A", "Bleomycin hydrolase", "Brain-specific angiogenesis inhibitor 1-associated protein 2", "Bromodomain", "Bromodomain-containing protein 2", "C-1-tetrahydrofolate synthase, cytoplasmic", "C-Jun-amino-terminal kinase-interacting protein 4", "C-terminal-binding protein 1", "C-terminal-binding protein 2", "C2H2 zinc finger transcription factor", "CAAX prenyl protease 1 homolog", "CAD protein", "CAMK group", "CAMK1 family", "CAMK2 family", "CAMKL family", "CASK family", "CCAAT/enhancer-binding protein zeta", "CCK4 family", "CCR4-NOT transcription complex subunit 1", "CCR4-NOT transcription complex subunit 2", "CD2 antigen cytoplasmic tail-binding protein 2", "CDC7 family", "CDK family", "CDK1 subfamily", "CDK4 subfamily", "CDK5 subfamily", "CK1 family", "CK1 group", "CK2 family", "CLIP-associating protein 1", "CMGC group", "COP9 signalosome complex subunit 3", "COP9 signalosome complex subunit 5", "COP9 signalosome complex subunit 6", "COP9 signalosome complex subunit 8", "CSK family", "CTP synthase 1", "CTP synthase 2", "Ca2+-ATPases", "Cadherin", "Calcium homeostasis endoplasmic reticulum protein", "Calcium uniporter protein, mitochondrial", "Calcium uptake protein 1, mitochondrial", "Calcium uptake protein 2, mitochondrial", "Calcium-binding mitochondrial carrier protein Aralar1", "Calcium-binding mitochondrial carrier protein Aralar2", "Calcium-binding mitochondrial carrier protein SCaMC-1", "Calcium-binding protein", "Calcium-binding protein 39", "Calcium-dependent chloride channel (ca-clc) family", "Calcium/calmodulin-dependent protein kinase type 1", "Calcium/calmodulin-dependent protein kinase type ii subunit gamma", "Calcyclin-binding protein", "Calmegin", "Calmodulin", "Calmodulin-3", "Calnexin", "Calpain-1 catalytic subunit", "Calpain-2 catalytic subunit", "Calponin-3", "Calreticulin", "Calumenin", "Camp-dependent protein kinase catalytic subunit alpha", "Cancer-related nucleoside-triphosphatase", "Caprin-1", "Carbohydrate kinase", "Carbohydrate sulfotransferase 14", "Carnitine O-palmitoyltransferase 1, liver isoform", "Carnitine O-palmitoyltransferase 2, mitochondrial", "Cartilage-associated protein", "Casein kinase II subunit alpha'", "Casein kinase i isoform alpha", "Casein kinase ii subunit beta", "Cat eye syndrome critical region protein 2", "Catechol O-methyltransferase", "Catenin alpha-1", "Catenin delta-1", "Cathepsin B", "Cation-dependent mannose-6-phosphate receptor", "Cation-independent mannose-6-phosphate receptor", "Cell adhesion", "Cell cycle and apoptosis regulator protein 2", "Cell division control protein 42 homolog", "Cell division cycle 7-related protein kinase", "Cell division cycle and apoptosis regulator protein 1", "Cell division cycle protein 20 homolog", "Cell-cell junction", "Cellular structure", "Cellular tumor antigen p53", "Centrin-2", "Centromere/kinetochore protein zw10 homolog", "Ceramide glucosyltransferase", "Chaperone", "Chaperonin", "Charged multivesicular body protein 3", "Charged multivesicular body protein 4b", "Charged multivesicular body protein 5", "Charged multivesicular body protein 7", "Chitobiosyldiphosphodolichol beta-mannosyltransferase", "Chloride channel CLIC-like protein 1", "Chloride channel family", "Chloride intracellular channel protein 1", "Chloride intracellular channel protein 4", "Choline kinase alpha", "Choline/ethanolamine kinase family", "Chromatin accessibility complex protein 1", "Chromatin assembly factor 1 subunit A", "Chromatin assembly factor 1 subunit B", "Chromatin/chromatin-binding protein", "Chromobox protein homolog 1", "Chromobox protein homolog 3", "Chromobox protein homolog 5", "Chromodomain", "Chromosome-associated kinesin KIF4A", "Cilia- and flagella-associated protein 20", "Citrate synthase, mitochondrial", "ClC-3/CLCN3 subfamily", "ClC-7/CLCN7 subfamily", "Clathrin heavy chain 1", "Clathrin light chain A", "Cleavage and polyadenylation specificity factor subunit 1", "Cleavage and polyadenylation specificity factor subunit 3", "Cleavage and polyadenylation specificity factor subunit 5", "Cleavage and polyadenylation specificity factor subunit 6", "Cleavage and polyadenylation specificity factor subunit 7", "Cleavage stimulation factor subunit 2", "Cleavage stimulation factor subunit 3", "Cleft lip and palate transmembrane protein 1", "Cleft lip and palate transmembrane protein 1-like protein", "Clustered mitochondria protein homolog", "Coactosin-like protein", "Coatomer subunit alpha", "Coatomer subunit beta", "Coatomer subunit beta'", "Coatomer subunit delta", "Coatomer subunit epsilon", "Coatomer subunit gamma-1", "Coatomer subunit gamma-2", "Coatomer subunit zeta-1", "Cohesin subunit SA-1", "Cohesin subunit SA-2", "Coilin", "Cold-inducible RNA-binding protein", "Collectin-12", "Condensin complex subunit 1", "Condensin-2 complex subunit D3", "Copper-transporting ATPase 2", "Core histone macro-H2A.1", "Core histone macro-H2A.2", "Coronin-1B", "Coronin-1C", "Coronin-7", "Creatine kinase B-type", "Creatine kinase U-type, mitochondrial", "Crooked neck-like protein 1", "Cu+-ATPases", "Cullin-1", "Cullin-2", "Cullin-4B", "Cullin-5", "Cullin-associated NEDD8-dissociated protein 1", "Cyclase", "Cyclin-dependent kinase 1", "Cyclin-dependent kinase 2", "Cyclin-dependent kinase 4", "Cyclin-dependent kinase 6", "Cyclin-dependent-like kinase 5", "Cyclin-g-associated kinase", "Cystatin-B", "Cysteine and glycine-rich protein 2", "Cysteine and histidine-rich domain-containing protein 1", "Cysteine protease", "Cysteine protease ATG4B", "Cysteine protease inhibitor", "Cysteine--tRNA ligase, cytoplasmic", "Cytochrome b-c1 complex subunit 1, mitochondrial", "Cytochrome b-c1 complex subunit 2, mitochondrial", "Cytochrome b-c1 complex subunit 7", "Cytochrome b-c1 complex subunit 9", "Cytochrome b5 type B", "Cytochrome c oxidase subunit 2", "Cytochrome c oxidase subunit 5A, mitochondrial", "Cytochrome c oxidase subunit 5B, mitochondrial", "Cytochrome c oxidase subunit 7A2, mitochondrial", "Cytochrome c oxidase subunit NDUFA4", "Cytochrome c-type heme lyase", "Cytokine", "Cytoplasmic FMR1-interacting protein 1", "Cytoplasmic FMR1-interacting protein 2", "Cytoplasmic aconitate hydratase", "Cytoplasmic dynein 1 heavy chain 1", "Cytoplasmic dynein 1 intermediate chain 2", "Cytoplasmic dynein 1 light intermediate chain 1", "Cytoplasmic dynein 1 light intermediate chain 2", "Cytoskeleton-associated protein 5", "Cytosol aminopeptidase", "Cytosolic acyl coenzyme A thioester hydrolase", "Cytosolic non-specific dipeptidase", "Cytosolic purine 5'-nucleotidase", "D-3-phosphoglycerate dehydrogenase", "D-dopachrome decarboxylase", "DDB1- and CUL4-associated factor 13", "DMPK family", "DNA (cytosine-5)-methyltransferase 1", "DNA binding protein", "DNA damage-binding protein 1", "DNA glycosylase", "DNA helicase", "DNA ligase", "DNA ligase 1", "DNA ligase 3", "DNA methyltransferase", "DNA mismatch repair protein Msh2", "DNA mismatch repair protein Msh3", "DNA mismatch repair protein Msh6", "DNA polymerase alpha subunit B", "DNA polymerase delta subunit 2", "DNA polymerase epsilon subunit 4", "DNA polymerase processivity factor", "DNA primase small subunit", "DNA replication complex GINS protein PSF2", "DNA replication licensing factor MCM2", "DNA replication licensing factor MCM3", "DNA replication licensing factor MCM4", "DNA replication licensing factor MCM5", "DNA replication licensing factor MCM6", "DNA replication licensing factor MCM7", "DNA topoisomerase", "DNA topoisomerase 1", "DNA-3-methyladenine glycosylase", "DNA-directed DNA polymerase", "DNA-directed RNA polymerase", "DNA-directed RNA polymerase I subunit RPA1", "DNA-directed RNA polymerase I subunit RPA2", "DNA-directed RNA polymerase I subunit RPA43", "DNA-directed RNA polymerase II subunit RPB1", "DNA-directed RNA polymerase II subunit RPB2", "DNA-directed RNA polymerase II subunit RPB3", "DNA-directed RNA polymerase II subunit RPB4", "DNA-directed RNA polymerase II subunit RPB7", "DNA-directed RNA polymerase III subunit RPC1", "DNA-directed RNA polymerase III subunit RPC3", "DNA-directed RNA polymerase, mitochondrial", "DNA-directed RNA polymerases I and III subunit RPAC1", "DNA-directed RNA polymerases I, II, and III subunit RPABC1", "DNA-directed RNA polymerases I, II, and III subunit RPABC2", "DNA-directed RNA polymerases I, II, and III subunit RPABC5", "DNAPK subfamily", "DYRK family", "Damaged DNA-binding protein", "Deacetylase", "Deaminase", "Death-inducer obliterator 1", "Decarboxylase", "Dedicator of cytokinesis protein 7", "Dehydratase", "Dehydrogenase", "Delta(24)-sterol reductase", "Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial", "Delta-1-pyrroline-5-carboxylate synthase", "Density-regulated protein", "Deoxycytidylate deaminase", "Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial", "Derlin-1", "Derlin-2", "Desmocollin-3", "Desmoglein-2", "Desmoplakin", "Diacylglycerol kinase epsilon", "Dihydrofolate reductase", "Dihydrolipoyl dehydrogenase, mitochondrial", "Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial", "Dihydropyrimidinase-related protein 2", "Dihydropyrimidinase-related protein 5", "Dipeptidyl peptidase 1", "Dipeptidyl peptidase 3", "Dipeptidyl peptidase 9", "Diphthine methyl ester synthase", "Disks large-associated protein 5", "Dna-dependent protein kinase catalytic subunit", "Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase", "Dolichol-phosphate mannosyltransferase subunit 1", "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit", "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1", "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2", "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1", "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A", "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B", "Dolichyldiphosphatase 1", "Double-stranded RNA-specific adenosine deaminase", "Drebrin", "Drebrin-like protein", "Dual specificity mitogen-activated protein kinase kinase 2", "Dual specificity protein kinase ttk", "Dynactin subunit 1", "Dynactin subunit 2", "Dynamin-1-like protein", "Dynamin-2", "Dynamin-like 120 kDa protein, mitochondrial", "Dynein light chain 2, cytoplasmic", "Dystonin", "Dystroglycan", "E3 SUMO-protein ligase RanBP2", "E3 ubiquitin-protein ligase ARIH1", "E3 ubiquitin-protein ligase ARIH2", "E3 ubiquitin-protein ligase HUWE1", "E3 ubiquitin-protein ligase Itchy homolog", "E3 ubiquitin-protein ligase MARCH5", "E3 ubiquitin-protein ligase RBBP6", "E3 ubiquitin-protein ligase RNF14", "EH domain-containing protein 1", "EH domain-containing protein 4", "ELKS/Rab6-interacting/CAST family member 1", "ELMO domain-containing protein 2", "ER lumen protein-retaining receptor 1", "ER membrane protein complex subunit 2", "ERK subfamily", "ERO1-like protein alpha", "Electron transfer flavoprotein subunit alpha, mitochondrial", "Electron transfer flavoprotein subunit beta", "Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial", "Elongation factor 1-alpha 2", "Elongation factor 1-beta", "Elongation factor 1-delta", "Elongation factor 2", "Elongation factor Ts, mitochondrial", "Elongation factor Tu, mitochondrial", "Elongation factor-like GTPase 1", "Elongator complex protein 1", "Elongator complex protein 3", "Elongin-B", "Elongin-C", "Endonuclease III-like protein 1", "Endoplasmic reticulum aminopeptidase 1", "Endoplasmic reticulum metallopeptidase 1", "Endoplasmic reticulum protein SC65", "Endoplasmic reticulum resident protein 29", "Endoplasmin", "Endoribonuclease", "Endothelin-converting enzyme 1", "Engulfment and cell motility protein 2", "Enhancer of mRNA-decapping protein 4", "Enhancer of rudimentary homolog", "Enolase-phosphatase E1", "Enoyl-CoA delta isomerase 1, mitochondrial", "Enoyl-CoA delta isomerase 2, mitochondrial", "Enoyl-CoA hydratase, mitochondrial", "Enzyme", "Enzyme modulator", "Eph family", "Ephrin type-a receptor 7", "Epidermal growth factor receptor substrate 15-like 1", "Epigenetic regulator", "Epimerase family protein SDR39U1", "Epimerase/racemase", "Epiplakin", "Eraser", "Erythrocyte band 7 integral membrane protein", "Esterase", "Ethanolamine kinase 1", "Ethylmalonyl-CoA decarboxylase", "Eukaryotic peptide chain release factor GTP-binding subunit ERF3A", "Eukaryotic peptide chain release factor subunit 1", "Eukaryotic translation initiation factor 2 subunit 1", "Eukaryotic translation initiation factor 2 subunit 2", "Eukaryotic translation initiation factor 2A", "Eukaryotic translation initiation factor 2D", "Eukaryotic translation initiation factor 3 subunit A", "Eukaryotic translation initiation factor 3 subunit B", "Eukaryotic translation initiation factor 3 subunit D", "Eukaryotic translation initiation factor 3 subunit E", "Eukaryotic translation initiation factor 3 subunit F", "Eukaryotic translation initiation factor 3 subunit H", "Eukaryotic translation initiation factor 3 subunit I", "Eukaryotic translation initiation factor 3 subunit J", "Eukaryotic translation initiation factor 3 subunit L", "Eukaryotic translation initiation factor 4 gamma 1", "Eukaryotic translation initiation factor 4 gamma 2", "Eukaryotic translation initiation factor 4 gamma 3", "Eukaryotic translation initiation factor 4B", "Eukaryotic translation initiation factor 4E", "Eukaryotic translation initiation factor 4H", "Eukaryotic translation initiation factor 5", "Eukaryotic translation initiation factor 5A-1", "Eukaryotic translation initiation factor 5B", "Eukaryotic translation initiation factor 6", "Exocyst complex component 3", "Exocyst complex component 5", "Exocyst complex component 6", "Exocyst complex component 6B", "Exocyst complex component 7", "Exodeoxyribonuclease", "Exonuclease 1", "Exoribonuclease", "Exosome complex component MTR3", "Exosome complex component RRP4", "Exosome complex component RRP40", "Exosome complex component RRP42", "Exosome complex component RRP45", "Exosome complex component RRP46", "Exosome complex exonuclease RRP44", "Exportin-1", "Exportin-2", "Exportin-4", "Exportin-5", "Exportin-7", "Exportin-T", "Extracellular matrix glycoprotein", "Extracellular matrix structural protein", "Extracellular structure", "Ezrin", "F-actin-capping protein subunit alpha-1", "F-actin-capping protein subunit alpha-2", "F-actin-capping protein subunit beta", "F-type ATPase", "F-type and V-type ATPases", "FACT complex subunit SPT16", "FAD-dependent oxidoreductase domain-containing protein 1", "FRAP subfamily", "FRAY subfamily", "Far upstream element-binding protein 1", "Far upstream element-binding protein 2", "Far upstream element-binding protein 3", "Farnesyl pyrophosphate synthase", "Fascin", "Fatty acid synthase", "Ferritin light chain", "Ferrochelatase, mitochondrial", "Flap endonuclease 1", "Folate transporter 1", "Fragile X mental retardation syndrome-related protein 1", "Fragile X mental retardation syndrome-related protein 2", "Fumarate hydratase, mitochondrial", "G patch domain-containing protein 4", "G-patch domain and KOW motifs-containing protein", "G-protein", "G-protein coupled receptor", "G-protein modulator", "G-rich sequence factor 1", "G2/mitotic-specific cyclin-B1", "GHMP kinase family", "GMP synthase [glutamine-hydrolyzing]", "GPI-anchor transamidase", "GTP-binding nuclear protein Ran", "GTP-binding protein 1", "GTP-binding protein Rheb", "GTPase Era, mitochondrial", "GTPase-activating protein and VPS9 domain-containing protein 1", "Galactokinase", "Galactosidase", "Gamma-adducin", "Gamma-aminobutyric acid receptor-associated protein-like 2", "Gamma-enolase", "Gamma-glutamyl hydrolase", "Gamma-taxilin", "Gamma-tubulin complex component 2", "Gamma-tubulin complex component 3", "Gamma-tubulin complex component 4", "Ganglioside GM2 activator", "General transcription factor 3C polypeptide 3", "General transcription factor IIF subunit 1", "General vesicular transport factor p115", "Glia maturation factor beta", "Glucosamine-6-phosphate isomerase 1", "Glucose-6-phosphate 1-dehydrogenase", "Glucose-6-phosphate isomerase", "Glucosidase", "Glucosidase 2 subunit beta", "Glutamate dehydrogenase 1, mitochondrial", "Glutamate--cysteine ligase catalytic subunit", "Glutaminase kidney isoform, mitochondrial", "Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1", "Glutamine--tRNA ligase", "Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial", "Glutaredoxin-3", "Glutathione reductase, mitochondrial", "Glutathione synthetase", "Glyceraldehyde-3-phosphate dehydrogenase", "Glycerol-3-phosphate acyltransferase 4", "Glycerol-3-phosphate dehydrogenase, mitochondrial", "Glycerol-3-phosphate phosphatase", "Glycine dehydrogenase (decarboxylating), mitochondrial", "Glycine--tRNA ligase", "Glycogen debranching enzyme", "Glycogen phosphorylase, brain form", "Glycogen phosphorylase, liver form", "Glycogenin-1", "Glycosidase", "Glycosylase", "Glycosyltransferase", "Glycylpeptide N-tetradecanoyltransferase 1", "Glyoxylate reductase/hydroxypyruvate reductase", "Golgi SNAP receptor complex member 1", "Golgi pH regulator family", "Golgi ph regulator b", "Golgin subfamily A member 2", "Group XV phospholipase A2", "Growth factor", "GrpE protein homolog 1, mitochondrial", "Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12", "Guanine nucleotide-binding protein G(i) subunit alpha-2", "Guanine nucleotide-binding protein G(k) subunit alpha", "Guanine nucleotide-binding protein subunit alpha-13", "Guanyl-nucleotide exchange factor", "H(+)/Cl(-) exchange transporter 3", "H(+)/Cl(-) exchange transporter 7", "H/ACA ribonucleoprotein complex subunit 1", "H/ACA ribonucleoprotein complex subunit 2", "HBS1-like protein", "HDAC class I", "HDAC class III", "HEAT repeat-containing protein 1", "HEAT repeat-containing protein 6", "HIV Tat-specific factor 1", "Haloacid dehalogenase-like hydrolase domain-containing 5", "Haloacid dehalogenase-like hydrolase domain-containing protein 2", "Heat shock protein 75 kDa, mitochondrial", "Heat shock protein HSP 90-alpha", "Heat shock protein HSP 90-beta", "Helicase", "Hepatoma-derived growth factor", "Hepatoma-derived growth factor-related protein 2", "Heterogeneous nuclear ribonucleoprotein F", "Heterogeneous nuclear ribonucleoprotein H", "Heterogeneous nuclear ribonucleoprotein H2", "Heterogeneous nuclear ribonucleoprotein H3", "Heterogeneous nuclear ribonucleoprotein K", "Heterogeneous nuclear ribonucleoprotein M", "Heterogeneous nuclear ribonucleoprotein Q", "Heterogeneous nuclear ribonucleoprotein R", "Heterotrimeric G-protein", "Hexokinase family", "Hexokinase-1", "Hexokinase-2", "High mobility group protein B1", "High mobility group protein B2", "High mobility group protein B3", "High mobility group protein HMG-I/HMG-Y", "Histidine triad nucleotide-binding protein 2, mitochondrial", "Histidine triad nucleotide-binding protein 3", "Histone", "Histone H1.0", "Histone H1.2", "Histone H1.3", "Histone H1.4", "Histone H1x", "Histone H2AX", "Histone H4", "Histone acetyltransferase KAT7", "Histone acetyltransferase type B catalytic subunit", "Histone deacetylase", "Histone deacetylase 1", "Histone deacetylase 2", "Histone deacetylase complex subunit SAP18", "Histone-arginine methyltransferase CARM1", "Histone-lysine N-methyltransferase NSD2", "Histone-lysine N-methyltransferase SMYD3", "Hormone", "Hsp90 co-chaperone Cdc37", "Hsp90 family chaperone", "Hydrolase", "Hydroxylase", "Hydroxymethylglutaryl-CoA lyase, mitochondrial", "Hypoxanthine-guanine phosphoribosyltransferase", "ILK subfamily", "Immune response", "Immunoglobulin fold transcription factor", "Importin subunit alpha-1", "Importin subunit alpha-4", "Importin subunit alpha-5", "Importin subunit alpha-7", "Importin subunit beta-1", "Importin-11", "Importin-4", "Importin-5", "Importin-7", "Importin-8", "Importin-9", "Inactive serine/threonine-protein kinase vrk3", "Inactive tyrosine-protein kinase 7", "Induced myeloid leukemia cell differentiation protein Mcl-1", "Inorganic pyrophosphatase", "Inorganic pyrophosphatase 2, mitochondrial", "Inosine triphosphate pyrophosphatase", "Inosine-5'-monophosphate dehydrogenase 1", "Inosine-5'-monophosphate dehydrogenase 2", "Inositol monophosphatase 1", "Inositol monophosphatase 3", "Inositol polyphosphate 5-phosphatase OCRL-1", "Insulin-degrading enzyme", "Insulin-like growth factor 2 mRNA-binding protein 1", "Insulin-like growth factor 2 mRNA-binding protein 2", "Insulin-like growth factor 2 mRNA-binding protein 3", "Integrator complex subunit 11", "Integrin beta-1", "Integrin-linked kinase-associated serine/threonine phosphatase 2C", "Integrin-linked protein kinase", "Interferon-induced, double-stranded rna-activated protein kinase", "Interferon-inducible double-stranded rna-dependent protein kinase activator a", "Interleukin enhancer-binding factor 3", "Intermediate filament", "Intermediate filament binding protein", "Intracellular calcium-sensing protein", "Intracellular chloride channel (clic) family", "Intracellular chloride channel (icc) family", "Ion channel", "Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial", "Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial", "Isoleucine--tRNA ligase, cytoplasmic", "Isoleucine--tRNA ligase, mitochondrial", "Isomerase", "Isopentenyl-diphosphate Delta-isomerase 1", "Isovaleryl-CoA dehydrogenase, mitochondrial", "Jumonji domain-containing", "KH domain-containing, RNA-binding, signal transduction-associated protein 1", "KRAB box transcription factor", "KRR1 small subunit processome component homolog", "Ketosamine-3-kinase", "Kinase", "Kinase activator", "Kinase inhibitor", "Kinase modulator", "Kinesin-1 heavy chain", "Kinesin-like protein KIF11", "Kinesin-like protein KIF14", "Kinesin-like protein KIF15", "Kinesin-like protein KIF18B", "Kinesin-like protein KIF20A", "Kinesin-like protein KIF22", "Kinesin-like protein KIF23", "Kinesin-like protein KIF2A", "Kinesin-like protein KIF2C", "Kinesin-like protein KIFC1", "Kinetochore protein Nuf2", "L-2-hydroxyglutarate dehydrogenase, mitochondrial", "L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase", "L-lactate dehydrogenase A chain", "L-lactate dehydrogenase B chain", "LIM domain and actin-binding protein 1", "LU7TM family", "La-related protein 1", "La-related protein 4", "La-related protein 4B", "La-related protein 7", "Lamin-B receptor", "Lamina-associated polypeptide 2, isoform alpha", "Lanosterol 14-alpha demethylase", "Large proline-rich protein BAG6", "Legumain", "Leucine-rich repeat and WD repeat-containing protein 1", "Leucine-rich repeat-containing protein 47", "Leucyl-cystinyl aminopeptidase", "Ligase", "Lipase", "Lipid kinase", "Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial", "Lon protease homolog, mitochondrial", "Long-chain fatty acid transport protein 4", "Long-chain-fatty-acid--CoA ligase 1", "Long-chain-fatty-acid--CoA ligase 3", "Long-chain-fatty-acid--CoA ligase 4", "Lupus La protein", "Lyase", "Lymphokine-activated killer t-cell-originated protein kinase", "Lysine demethylase", "Lysine--tRNA ligase", "Lysine-specific demethylase", "Lysine-specific demethylase 3B", "Lysine-specific histone demethylase 1A", "Lysine-specific histone demethylase 1B", "Lysophosphatidic acid phosphatase type 6", "Lysophosphatidylcholine acyltransferase 1", "Lysophospholipid acyltransferase 5", "Lysophospholipid acyltransferase 7", "Lysosomal Pro-X carboxypeptidase", "Lysosomal acid lipase/cholesteryl ester hydrolase", "Lysosomal acid phosphatase", "Lysosomal alpha-glucosidase", "Lysosomal protective protein", "Lysosomal thioesterase PPT2", "Lysosome membrane protein 2", "Lysosome-associated membrane glycoprotein 1", "Lysosome-associated membrane glycoprotein 2", "MAGUK p55 subfamily member 6", "MAPK family", "MAST family", "MCU family", "MLK family", "MMS19 nucleotide excision repair protein homolog", "MOB-like protein phocein", "MST subfamily", "Magnesium transporter protein 1", "Major facilitator superfamily domain-containing protein 3", "Major histocompatibility complex antigen", "Malate dehydrogenase, cytoplasmic", "Malate dehydrogenase, mitochondrial", "Malignant T-cell-amplified sequence 1", "Mannose-6-phosphate isomerase", "Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA", "Mediator of RNA polymerase II transcription subunit 21", "Mediator of RNA polymerase II transcription subunit 25", "Medium-chain specific acyl-CoA dehydrogenase, mitochondrial", "Melanoma inhibitory activity protein 2", "Melanoma-associated antigen D2", "Membralin", "Membrane trafficking regulatory protein", "Membrane-associated progesterone receptor component 1", "Membrane-associated progesterone receptor component 2", "Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase", "Metalloprotease", "Metastasis-associated protein MTA1", "Metastasis-associated protein MTA2", "Methyl-CpG-binding domain", "Methyl-CpG-binding protein 2", "Methyl-lysine/arginine binding protein", "Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial", "Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial", "Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial", "Methylmalonyl-CoA mutase, mitochondrial", "Methylosome subunit pICln", "Methylsterol monooxygenase 1", "Methyltransferase", "Methyltransferase-like protein 7A", "Methyltransferase-like protein 7B", "Mevalonate kinase", "Mevalonate kinase subfamily", "Microsomal glutathione S-transferase 2", "Microsomal glutathione S-transferase 3", "Microtubule binding motor protein", "Microtubule family cytoskeletal protein", "Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5", "Microtubule-associated protein 1B", "Microtubule-associated protein 1S", "Microtubule-associated protein RP/EB family member 1", "Microtubule-associated protein RP/EB family member 2", "Minor histocompatibility antigen H13", "Miscellaneous SLC25 mitochondrial transporters", "Mitochondrial 2-oxodicarboxylate carrier", "Mitochondrial 2-oxoglutarate/malate carrier protein", "Mitochondrial Rho GTPase 1", "Mitochondrial Rho GTPase 2", "Mitochondrial amino acid transporter subfamily", "Mitochondrial cardiolipin hydrolase", "Mitochondrial carnitine/acylcarnitine carrier protein", "Mitochondrial carrier homolog 1", "Mitochondrial carrier homolog 2", "Mitochondrial coenzyme A transporter SLC25A42", "Mitochondrial di- and tri-carboxylic acid transporter subfamily", "Mitochondrial dicarboxylate carrier", "Mitochondrial folate transporter/carrier", "Mitochondrial glutamate carrier 1", "Mitochondrial import inner membrane translocase subunit Tim10 B", "Mitochondrial import receptor subunit TOM20 homolog", "Mitochondrial import receptor subunit TOM40 homolog", "Mitochondrial inner membrane protein OXA1L", "Mitochondrial intermediate peptidase", "Mitochondrial nucleotide transporter subfamily", "Mitochondrial ornithine transporter 1", "Mitochondrial phosphate transporters", "Mitochondrial proton/calcium exchanger protein", "Mitochondrial pyruvate carrier 2", "Mitochondrial thiamine pyrophosphate carrier", "Mitochondrial-processing peptidase subunit alpha", "Mitochondrial-processing peptidase subunit beta", "Mitofusin-1", "Mitofusin-2", "Mitogen-activated protein kinase 1", "Mitogen-activated protein kinase 14", "Mitotic checkpoint protein BUB3", "Mitotic checkpoint serine/threonine-protein kinase bub1 beta", "Moesin", "Molybdate-anion transporter", "Monoacylglycerol lipase ABHD12", "Monoacylglycerol lipase ABHD6", "Monocarboxylate transporter 1", "Monofunctional C1-tetrahydrofolate synthase, mitochondrial", "Mortality factor 4-like protein 1", "Mpv17-like protein 2", "Multidrug resistance protein 1", "Multidrug resistance-associated protein 1", "Multifunctional protein ADE2", "Mutase", "Myb-binding protein 1A", "Myelin expression factor 2", "Myosin light polypeptide 6", "Myosin phosphatase Rho-interacting protein", "Myotubularin-related protein 2", "N(G),N(G)-dimethylarginine dimethylaminohydrolase 2", "N-acetylglucosamine-6-sulfatase", "N-acylneuraminate cytidylyltransferase", "N-alpha-acetyltransferase 15, NatA auxiliary subunit", "N-alpha-acetyltransferase 25, NatB auxiliary subunit", "N-alpha-acetyltransferase 35, NatC auxiliary subunit", "N-alpha-acetyltransferase 50", "N-terminal Xaa-Pro-Lys N-methyltransferase 1", "N6-adenosine-methyltransferase non-catalytic subunit", "NAD kinase 2, mitochondrial", "NAD(P) transhydrogenase, mitochondrial", "NAD-dependent malic enzyme, mitochondrial", "NAD-dependent protein deacetylase sirtuin-1", "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13", "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5", "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8", "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial", "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1", "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4", "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial", "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9", "NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial", "NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial", "NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial", "NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial", "NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial", "NADH-ubiquinone oxidoreductase chain 1", "NADP-dependent malic enzyme", "NADPH:adrenodoxin oxidoreductase, mitochondrial", "NAK family", "NEDD8-activating enzyme E1 catalytic subunit", "NEDD8-activating enzyme E1 regulatory subunit", "NEK family", "NF-kappa-B-repressing factor", "NLR family member X1", "Na+/K+-ATPases", "Nardilysin", "Neuferricin", "Neurolysin, mitochondrial", "Neuropathy target esterase", "Neutral alpha-glucosidase AB", "Neutral amino acid transporter B(0)", "Neutral amino acid transporter subfamily", "Nf-kappa-b essential modulator", "Nicotinamide phosphoribosyltransferase", "Non-POU domain-containing octamer-binding protein", "Non-histone chromosomal protein HMG-17", "Non-motor actin binding protein", "Non-motor microtubule binding protein", "Non-protein kinase", "Nuclear RNA export factor 1", "Nuclear cap-binding protein subunit 1", "Nuclear migration protein nudC", "Nuclear pore complex protein Nup107", "Nuclear pore complex protein Nup153", "Nuclear pore complex protein Nup160", "Nuclear pore complex protein Nup214", "Nuclear pore complex protein Nup85", "Nuclear pore complex protein Nup88", "Nuclear pore complex protein Nup93", "Nuclear pore complex protein Nup98-Nup96", "Nuclear pore glycoprotein p62", "Nuclear pore membrane glycoprotein 210", "Nuclease", "Nucleic acid binding", "Nucleobindin-1", "Nucleobindin-2", "Nucleolar MIF4G domain-containing protein 1", "Nucleolar complex protein 4 homolog", "Nucleolar protein 14", "Nucleolar protein 56", "Nucleolar protein 58", "Nucleolar protein 6", "Nucleolar protein 9", "Nucleolin", "Nucleophosmin", "Nucleoporin Nup37", "Nucleoporin SEH1", "Nucleoporin p54", "Nucleoside diphosphate kinase A", "Nucleoside kinase", "Nucleosome assembly protein 1-like 1", "Nucleosome assembly protein 1-like 4", "Nucleotide kinase", "Nucleotide phosphatase", "Nucleotidyltransferase", "NudC domain-containing protein 2", "OCIA domain-containing protein 1", "OTU domain-containing protein 4", "OTU domain-containing protein 7B", "Obg-like ATPase 1", "Occludin", "Ornithine aminotransferase, mitochondrial", "Other 7TM proteins", "Other group", "Other small molecule kinase", "Oxidase", "Oxidoreductase", "Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial", "Oxygenase", "P-type ATPases", "P38 subfamily", "P53-like transcription factor", "PAKA subfamily", "PC4 and SFRS1-interacting protein", "PDHK family", "PDZ and LIM domain protein 1", "PDZ and LIM domain protein 5", "PDZ and LIM domain protein 7", "PEK family", "PH-interacting protein", "PHD finger protein 6", "PI3/PI4 kinase family", "PIKK family", "PIN2/TERF1-interacting telomerase inhibitor 1", "PKA family", "PKC alpha subfamily", "PKC family", "PKN family", "PLK family", "Paired amphipathic helix protein Sin3a", "Palmitoyl-protein thioesterase 1", "Pantothenate kinase 4", "Paraspeckle component 1", "Paxillin", "Peptidase M20 domain-containing protein 2", "Peptidyl-prolyl cis-trans isomerase FKBP1A", "Peptidyl-prolyl cis-trans isomerase FKBP4", "Peptidyl-prolyl cis-trans isomerase FKBP5", "Peptidyl-prolyl cis-trans isomerase-like 1", "Peptidyl-prolyl cis-trans isomerase-like 3", "Peptidylprolyl isomerase domain and WD repeat-containing protein 1", "Perilipin-3", "Periodic tryptophan protein 1 homolog", "Peripheral plasma membrane protein cask", "Peroxidase", "Peroxiredoxin-2", "Peroxiredoxin-4", "Peroxiredoxin-6", "Peroxisomal acyl-coenzyme A oxidase 1", "Peroxisomal acyl-coenzyme A oxidase 3", "Peroxisomal biogenesis factor 19", "Peroxisomal carnitine O-octanoyltransferase", "Peroxisomal membrane protein 2", "Peroxisomal membrane protein PEX14", "Peroxisomal membrane protein PMP34", "Peroxisomal targeting signal 1 receptor", "Peroxisomal trans-2-enoyl-CoA reductase", "Pescadillo homolog", "Phenylalanine--tRNA ligase beta subunit", "Phenylalanine--tRNA ligase, mitochondrial", "Phosphatase", "Phosphatase activator", "Phosphatase inhibitor", "Phosphatase modulator", "Phosphate carrier protein, mitochondrial", "Phosphatidylethanolamine-binding protein 1", "Phosphatidylinositol 4-kinase beta", "Phosphatidylinositol 4-kinase type 2-alpha", "Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma", "Phosphatidylinositol transfer protein beta isoform", "Phosphatidylinositol-binding clathrin assembly protein", "Phosphatidylserine synthase 1", "Phosphodiesterase", "Phosphoenolpyruvate carboxykinase [GTP] family", "Phosphoenolpyruvate carboxykinase [gtp], mitochondrial", "Phosphofructokinase type A (PFKA) family", "Phosphoglycerate kinase 1", "Phosphoglycerate kinase family", "Phosphoinositide 3-kinase regulatory subunit 4", "Phospholipase", "Phospholipase A-2-activating protein", "Phosphoribosyl pyrophosphate synthase-associated protein 1", "Phosphoribosyl pyrophosphate synthase-associated protein 2", "Phosphoribosyltransferase domain-containing protein 1", "Phosphorylase", "Phosphorylase b kinase regulatory chain family", "Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform", "Phosphorylated adapter RNA export protein", "Pirin", "Plasma membrane calcium-transporting ATPase 1", "Plasminogen activator inhibitor 1 RNA-binding protein", "Plastin-3", "Plectin", "Pogo transposable element with ZNF domain", "Poly(A) RNA polymerase, mitochondrial", "Poly(A) polymerase alpha", "Poly(A)-specific ribonuclease PARN", "Poly(ADP-ribose) glycohydrolase", "Poly(rC)-binding protein 1", "Poly(rC)-binding protein 2", "Polyadenylate-binding protein-interacting protein 1", "Polycomb protein SUZ12", "Polyhomeotic-like protein 2", "Polymerase", "Polymerase delta-interacting protein 3", "Polypeptide N-acetylgalactosaminyltransferase 1", "Polypeptide N-acetylgalactosaminyltransferase 2", "Polypeptide N-acetylgalactosaminyltransferase 4", "Polyribonucleotide nucleotidyltransferase 1, mitochondrial", "Porphobilinogen deaminase", "Pre-mRNA-processing factor 17", "Pre-mRNA-processing factor 39", "Pre-mRNA-processing factor 6", "Pre-mRNA-processing-splicing factor 8", "Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15", "Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16", "Pre-mRNA-splicing factor RBM22", "Pre-mRNA-splicing factor SPF27", "Pre-mRNA-splicing factor SYF1", "Prefoldin subunit 2", "Prefoldin subunit 3", "Prefoldin subunit 5", "Prenylated Rab acceptor protein 1", "Presequence protease, mitochondrial", "Primase", "Probable 18S rRNA (guanine-N(7))-methyltransferase", "Probable ATP-dependent RNA helicase DHX37", "Probable ATP-dependent RNA helicase DHX40", "Probable E3 ubiquitin-protein ligase makorin-2", "Probable RNA-binding protein 19", "Probable U3 small nucleolar RNA-associated protein 11", "Probable cysteine--tRNA ligase, mitochondrial", "Probable global transcription activator SNF2L1", "Probable glutamate--tRNA ligase, mitochondrial", "Probable leucine--tRNA ligase, mitochondrial", "Probable ribosome biogenesis protein RLP24", "Probable serine carboxypeptidase CPVL", "Probable tRNA N6-adenosine threonylcarbamoyltransferase", "Probable tRNA pseudouridine synthase 1", "Procollagen galactosyltransferase 1", "Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1", "Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2", "Programmed cell death 6-interacting protein", "Programmed cell death protein 5", "Prolactin regulatory element-binding protein", "Proliferating cell nuclear antigen", "Prolyl 3-hydroxylase 1", "Prolyl endopeptidase", "Propionyl-CoA carboxylase alpha chain, mitochondrial", "Propionyl-CoA carboxylase beta chain, mitochondrial", "Prostaglandin E synthase 2", "Prostaglandin E synthase 3", "Prostaglandin reductase 1", "Prostaglandin reductase 2", "Prostaglandin reductase 3", "Protease", "Protease inhibitor", "Protein AATF", "Protein BUD31 homolog", "Protein CMSS1", "Protein DDI1 homolog 2", "Protein FAM177A1", "Protein Mpv17", "Protein PAT1 homolog 1", "Protein PRRC2A", "Protein PRRC2C", "Protein RRP5 homolog", "Protein Red", "Protein S100-A11", "Protein S100-A13", "Protein SCO1 homolog, mitochondrial", "Protein SCO2 homolog, mitochondrial", "Protein SET", "Protein SYS1 homolog", "Protein Wiz", "Protein angel homolog 1", "Protein arginine N-methyltransferase 1", "Protein arginine N-methyltransferase 3", "Protein arginine N-methyltransferase 5", "Protein arginine methyltransferase", "Protein farnesyltransferase subunit beta", "Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha", "Protein gpr107", "Protein kinase", "Protein kinase C and casein kinase substrate in neurons protein 2", "Protein kinase c beta type", "Protein methyltransferase", "Protein pelota homolog", "Protein phosphatase", "Protein phosphatase 1G", "Protein phosphatase methylesterase 1", "Protein polybromo-1", "Protein quaking", "Protein regulator of cytokinesis 1", "Protein spinster homolog 1", "Protein transport protein Sec23A", "Protein transport protein Sec23B", "Protein transport protein Sec24A", "Protein transport protein Sec24B", "Protein transport protein Sec24C", "Protein transport protein Sec24D", "Protein transport protein Sec31A", "Protein transport protein Sec61 subunit alpha isoform 1", "Protein tweety homolog 3", "Protein unc-119 homolog A", "Protein unc-119 homolog B", "Protein-L-isoaspartate(D-aspartate) O-methyltransferase", "Protein/nucleic acid deglycase DJ-1", "Pseudouridine-5'-phosphatase", "Pterin-4-alpha-carbinolamine dehydratase", "Pumilio homolog 1", "Purine nucleoside phosphorylase", "Puromycin-sensitive aminopeptidase", "Putative ATP-dependent RNA helicase DHX57", "Putative oxidoreductase GLYR1", "Putative phospholipase B-like 2", "Pyridoxal kinase", "Pyridoxine kinase family", "Pyrophosphatase", "Pyruvate carboxylase, mitochondrial", "Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial", "Pyruvate kinase pkm", "RAF family", "RNA 3'-terminal phosphate cyclase-like protein", "RNA binding protein", "RNA helicase", "RNA-binding motif protein, X chromosome", "RNA-binding protein 12", "RNA-binding protein 14", "RNA-binding protein 26", "RNA-binding protein 27", "RNA-binding protein 4", "RNA-binding protein EWS", "RNA-binding protein FUS", "ROCK subfamily", "RSK family", "RSK subfamily", "Rab GDP dissociation inhibitor alpha", "Rab GDP dissociation inhibitor beta", "Rab GTPase-activating protein 1", "Rab3 GTPase-activating protein non-catalytic subunit", "Rac GTPase-activating protein 1", "Rac-beta serine/threonine-protein kinase", "Radixin", "Ran GTPase-activating protein 1", "Ran-binding protein 3", "Ran-binding protein 6", "Ran-binding protein 9", "Ran-specific GTPase-activating protein", "Rap guanine nucleotide exchange factor 2", "Ras GTPase-activating protein-binding protein 1", "Ras GTPase-activating protein-binding protein 2", "Ras GTPase-activating-like protein IQGAP1", "Ras GTPase-activating-like protein IQGAP2", "Ras-related C3 botulinum toxin substrate 1", "Ras-related protein Ral-A", "Ras-related protein Rap-2b", "Reader", "Receptor", "Receptor expression-enhancing protein 4", "Receptor expression-enhancing protein 5", "Receptor-type tyrosine-protein phosphatase F", "Reductase", "Regulation of nuclear pre-mRNA domain-containing protein 1A", "Regulation of nuclear pre-mRNA domain-containing protein 1B", "Regulation of nuclear pre-mRNA domain-containing protein 2", "Regulator of nonsense transcripts 1", "Renin receptor", "Replication factor C subunit 2", "Replication factor C subunit 3", "Replication factor C subunit 4", "Replication factor C subunit 5", "Replication protein A 70 kDa DNA-binding subunit", "Reticulocalbin-1", "Reticulocalbin-2", "Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta", "Retinoid-inducible serine carboxypeptidase", "Retinol dehydrogenase 11", "Retinol dehydrogenase 14", "Rho GDP-dissociation inhibitor 1", "Rho-associated protein kinase 1", "Rho-related GTP-binding protein RhoG", "Rhomboid domain-containing protein 2", "Ribonuclease H2 subunit A", "Ribonuclease P protein subunit p30", "Ribonuclease inhibitor", "Ribonucleoprotein", "Ribonucleoprotein PTB-binding 1", "Ribonucleoside-diphosphate reductase large subunit", "Ribonucleoside-diphosphate reductase subunit M2", "Ribosomal L1 domain-containing protein 1", "Ribosomal RNA small subunit methyltransferase NEP1", "Ribosomal protein", "Ribosomal protein s6 kinase alpha-1", "Ribosomal protein s6 kinase alpha-3", "Ribosome biogenesis protein BOP1", "Ribosome biogenesis protein BRX1 homolog", "Ribosome biogenesis regulatory protein homolog", "Ribosome maturation protein SBDS", "Ribosome production factor 1", "Ribosome production factor 2 homolog", "Ribosome-recycling factor, mitochondrial", "S-adenosylhomocysteine hydrolase-like protein 1", "S-adenosylmethionine mitochondrial carrier protein", "S-adenosylmethionine synthase isoform type-2", "S-formylglutathione hydrolase", "S-methyl-5'-thioadenosine phosphorylase", "S-phase kinase-associated protein 1", "SEC23-interacting protein", "SET domain", "SLC superfamily of solute carriers", "SLC1 family of amino acid transporters", "SLC12 family of cation-coupled chloride transporters", "SLC16 family of monocarboxylate transporters", "SLC19 family of vitamin transporters", "SLC22 family of organic cation and anion transporters", "SLC25 family of mitochondrial transporters", "SLC27 family of fatty acid transporters", "SLC3 and SLC7 families of heteromeric amino acid transporters (HATs)", "SLC3 family", "SLC30 zinc transporter family", "SLC33 acetylCoA transporter", "SLC35 family of nucleotide sugar transporters", "SLC39 family of metal ion transporters", "SLC4 family of bicarbonate transporters", "SLC54 Mitochondrial pyruvate carriers", "SLC55 Mitochondrial cation/proton exchangers", "SLC56 Sideroflexins", "SLC58 MagT-like magnesium transporter family", "SLC6 neurotransmitter transporter family", "SLC61 Molybdate transporter family", "SLC63 Sphingosine-phosphate transporters", "SLC64 Golgi Ca2+/H+ exchangers", "SLK subfamily", "SNARE protein", "SNW domain-containing protein 1", "SRPK family", "STAM-binding protein", "STE group", "STE20 family", "STE7 family", "SUMO-activating enzyme subunit 1", "SUMO-activating enzyme subunit 2", "SUN domain-containing protein 1", "SUN domain-containing protein 2", "SURP and G-patch domain-containing protein 1", "SURP and G-patch domain-containing protein 2", "SWI/SNF complex subunit SMARCC1", "SWI/SNF complex subunit SMARCC2", "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1", "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5", "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1", "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1", "Sarcoplasmic/endoplasmic reticulum calcium ATPase 2", "Scavenger receptor class B member 1", "Sec1 family domain-containing protein 1", "Secretory carrier-associated membrane protein 1", "Secretory carrier-associated membrane protein 2", "Secretory carrier-associated membrane protein 3", "Selenide, water dikinase 1", "Sentrin-specific protease 3", "Separin", "Septin-11", "Septin-2", "Septin-6", "Septin-7", "Septin-9", "Serine hydroxymethyltransferase, cytosolic", "Serine hydroxymethyltransferase, mitochondrial", "Serine palmitoyltransferase 1", "Serine palmitoyltransferase 2", "Serine protease", "Serine protease inhibitor", "Serine--tRNA ligase, cytoplasmic", "Serine--tRNA ligase, mitochondrial", "Serine/arginine repetitive matrix protein 1", "Serine/arginine-rich splicing factor 1", "Serine/arginine-rich splicing factor 10", "Serine/arginine-rich splicing factor 11", "Serine/arginine-rich splicing factor 3", "Serine/arginine-rich splicing factor 5", "Serine/arginine-rich splicing factor 6", "Serine/arginine-rich splicing factor 7", "Serine/arginine-rich splicing factor 9", "Serine/threonine-protein kinase 26", "Serine/threonine-protein kinase 4", "Serine/threonine-protein kinase a-raf", "Serine/threonine-protein kinase greatwall", "Serine/threonine-protein kinase mtor", "Serine/threonine-protein kinase n1", "Serine/threonine-protein kinase n2", "Serine/threonine-protein kinase nek9", "Serine/threonine-protein kinase osr1", "Serine/threonine-protein kinase pak 2", "Serine/threonine-protein kinase plk1", "Serine/threonine-protein kinase prp4 homolog", "Serine/threonine-protein kinase tao1", "Serine/threonine-protein kinase ulk3", "Serine/threonine-protein kinase vrk1", "Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform", "Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform", "Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform", "Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform", "Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform", "Serine/threonine-protein phosphatase 2A activator", "Serine/threonine-protein phosphatase 4 regulatory subunit 1", "Serine/threonine-protein phosphatase 6 regulatory subunit 3", "Serine/threonine-protein phosphatase PP1-alpha catalytic subunit", "Serine/threonine-protein phosphatase PP1-beta catalytic subunit", "Serpin B6", "Serpin H1", "Sex comb on midleg-like protein 2", "Sialic acid synthase", "Sideroflexin-1", "Sideroflexin-2", "Sigma intracellular receptor 2", "Signal peptidase complex catalytic subunit SEC11A", "Signal peptidase complex subunit 2", "Signal recognition particle 14 kDa protein", "Signal recognition particle 54 kDa protein", "Signal recognition particle 9 kDa protein", "Signal recognition particle receptor subunit alpha", "Signal recognition particle subunit SRP68", "Signal transducer and activator of transcription 1-alpha/beta", "Signal transducer and activator of transcription 3", "Signaling", "Single-stranded DNA-binding protein, mitochondrial", "Sister chromatid cohesion protein PDS5 homolog A", "Sister chromatid cohesion protein PDS5 homolog B", "Small GTPase", "Small nuclear ribonucleoprotein E", "Small nuclear ribonucleoprotein Sm D1", "Small nuclear ribonucleoprotein Sm D2", "Small nuclear ribonucleoprotein Sm D3", "Sodium bicarbonate cotransporter 3", "Sodium-dependent HCO3- transporters", "Sodium-dependent neutral amino acid transporter B(0)AT2", "Sodium/potassium-transporting ATPase subunit alpha-1", "Sodium/potassium-transporting ATPase subunit beta-1", "Sodium/potassium-transporting ATPase subunit beta-3", "Solute carrier family 12 member 9", "Solute carrier family 25 member 33", "Solute carrier family 25 member 40", "Solute carrier family 35 member F2", "Something about silencing protein 10", "Sorbitol dehydrogenase", "Sorting nexin-1", "Sorting nexin-19", "Sorting nexin-2", "Spermatid perinuclear RNA-binding protein", "Spermidine synthase", "Sphingosine kinase 2", "Splicing factor 1", "Splicing factor 3A subunit 1", "Splicing factor 3A subunit 2", "Splicing factor 3A subunit 3", "Splicing factor 3B subunit 1", "Splicing factor 3B subunit 3", "Splicing factor 45", "Splicing factor U2AF 35 kDa subunit", "Splicing factor, arginine/serine-rich 15", "Splicing factor, proline- and glutamine-rich", "Splicing regulatory glutamine/lysine-rich protein 1", "Squalene monooxygenase", "Squamous cell carcinoma antigen recognized by T-cells 3", "Src substrate cortactin", "Srsf protein kinase 1", "Srsf protein kinase 2", "Staphylococcal nuclease domain-containing protein 1", "Ste20-like serine/threonine-protein kinase", "Sterol O-acyltransferase 1", "Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating", "Stomatin-like protein 2, mitochondrial", "Storage", "Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial", "Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial", "Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial", "Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial", "Succinate-semialdehyde dehydrogenase, mitochondrial", "Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial", "Sulfhydryl oxidase 2", "Superoxide dismutase [Mn], mitochondrial", "Surfeit locus protein 4", "Surfeit locus protein 6", "Survival motor neuron protein", "Synaptic functional regulator FMR1", "Synaptic vesicle glycoprotein 2A", "Synaptogyrin-2", "Synaptojanin-2-binding protein", "Synaptosomal-associated protein 23", "Syntaxin-10", "Syntaxin-12", "Syntaxin-18", "Syntaxin-3", "Syntaxin-4", "Syntaxin-5", "Syntaxin-7", "Syntaxin-8", "Syntaxin-binding protein 3", "Syntenin-1", "T-complex protein 1 subunit alpha", "T-complex protein 1 subunit beta", "T-complex protein 1 subunit delta", "T-complex protein 1 subunit epsilon", "T-complex protein 1 subunit eta", "T-complex protein 1 subunit gamma", "T-complex protein 1 subunit theta", "T-complex protein 1 subunit zeta", "TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L", "TAO subfamily", "TATA-binding protein-associated factor 2N", "TBC1 domain family member 13", "TBC1 domain family member 15", "TBC1 domain family member 2B", "TBC1 domain family member 4", "TBC1 domain family member 9B", "THO complex subunit 1", "THO complex subunit 2", "THO complex subunit 3", "THO complex subunit 4", "TK group", "TKL group", "TNF receptor-associated factor 2", "TOPK family", "TTK family", "Target of EGR1 protein 1", "Targeting protein for Xklp2", "Testin", "Tgf-beta-activated kinase 1 and map3k7-binding protein 1", "Thimet oligopeptidase", "Thioredoxin domain-containing protein 12", "Thioredoxin domain-containing protein 17", "Thioredoxin domain-containing protein 9", "Thioredoxin reductase 1, cytoplasmic", "Thioredoxin-dependent peroxide reductase, mitochondrial", "Thiosulfate sulfurtransferase", "Threonine--tRNA ligase, cytoplasmic", "Threonine--tRNA ligase, mitochondrial", "Thymidine kinase family", "Thymidine kinase, cytosolic", "Thymidylate kinase", "Thymidylate kinase family", "Thymidylate synthase", "Thyroid hormone receptor-associated protein 3", "Tight junction", "Tight junction protein ZO-1", "Tmem38 family", "Torsin-1B", "Torsin-3A", "Trans-Golgi network integral membrane protein 2", "Transaminase", "Transcription activator BRG1", "Transcription cofactor", "Transcription elongation factor A protein 1", "Transcription elongation factor SPT6", "Transcription elongation regulator 1", "Transcription factor", "Transcription initiation factor IIB", "Transcriptional activator protein Pur-alpha", "Transcriptional repressor CTCF", "Transcriptional repressor p66-alpha", "Transcriptional repressor p66-beta", "Transferase", "Transferrin receptor protein 1", "Transformer-2 protein homolog alpha", "Transformer-2 protein homolog beta", "Transgelin-2", "Transketolase", "Translation elongation factor", "Translation factor", "Translation factor GUF1, mitochondrial", "Translation initiation factor", "Translation release factor", "Translationally-controlled tumor protein", "Translocation protein SEC63 homolog", "Translocon-associated protein subunit alpha", "Transmembrane 9 superfamily member 2", "Transmembrane 9 superfamily member 3", "Transmembrane 9 superfamily member 4", "Transmembrane emp24 domain-containing protein 10", "Transmembrane emp24 domain-containing protein 2", "Transmembrane emp24 domain-containing protein 4", "Transmembrane emp24 domain-containing protein 5", "Transmembrane emp24 domain-containing protein 7", "Transmembrane emp24 domain-containing protein 9", "Transmembrane protein 165", "Transport and Golgi organization protein 1 homolog", "Transporter", "Transportin-1", "Transportin-2", "Transportin-3", "Tricarboxylate transport protein, mitochondrial", "Trifunctional enzyme subunit alpha, mitochondrial", "Trifunctional enzyme subunit beta, mitochondrial", "Trifunctional purine biosynthetic protein adenosine-3", "Trimeric intracellular cation channel type B", "Triosephosphate isomerase", "Tripeptidyl-peptidase 1", "Tripeptidyl-peptidase 2", "Tropomodulin-1", "Tropomodulin-3", "Tropomyosin alpha-1 chain", "Tropomyosin alpha-3 chain", "Tropomyosin alpha-4 chain", "Tryptophan--tRNA ligase, cytoplasmic", "Tubulin", "Tubulin beta chain", "Tubulin beta-2A chain", "Tubulin beta-2B chain", "Tubulin beta-3 chain", "Tubulin beta-4B chain", "Tubulin beta-6 chain", "Tubulin-folding cofactor B", "Tubulin-specific chaperone A", "Tubulin-specific chaperone D", "Tubulin-specific chaperone E", "Tudor and KH domain-containing protein", "Tudor domain", "Tuftelin-interacting protein 11", "Tumor susceptibility gene 101 protein", "Twinfilin-1", "Twinfilin-2", "Twinkle protein, mitochondrial", "Type II PI4K subfamily", "Tyrosine--tRNA ligase, cytoplasmic", "Tyrosine--tRNA ligase, mitochondrial", "Tyrosine-protein kinase csk", "U1 small nuclear ribonucleoprotein 70 kDa", "U1 small nuclear ribonucleoprotein A", "U2 small nuclear ribonucleoprotein A'", "U2 small nuclear ribonucleoprotein B''", "U2 snRNP-associated SURP motif-containing protein", "U3 small nucleolar RNA-associated protein 14 homolog A", "U3 small nucleolar RNA-associated protein 6 homolog", "U3 small nucleolar ribonucleoprotein protein IMP3", "U3 small nucleolar ribonucleoprotein protein IMP4", "U3 small nucleolar ribonucleoprotein protein MPP10", "U4/U6 small nuclear ribonucleoprotein Prp31", "U4/U6 small nuclear ribonucleoprotein Prp4", "U4/U6.U5 tri-snRNP-associated protein 1", "U4/U6.U5 tri-snRNP-associated protein 2", "U6 snRNA-associated Sm-like protein LSm2", "U6 snRNA-associated Sm-like protein LSm3", "U6 snRNA-associated Sm-like protein LSm4", "U6 snRNA-associated Sm-like protein LSm6", "U6 snRNA-associated Sm-like protein LSm7", "UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase", "UDP-glucose:glycoprotein glucosyltransferase 1", "ULK family", "UMP-CMP kinase", "UV excision repair protein RAD23 homolog A", "UV excision repair protein RAD23 homolog B", "Ubiquitin carboxyl-terminal hydrolase 10", "Ubiquitin carboxyl-terminal hydrolase 11", "Ubiquitin carboxyl-terminal hydrolase 14", "Ubiquitin carboxyl-terminal hydrolase 28", "Ubiquitin carboxyl-terminal hydrolase 36", "Ubiquitin carboxyl-terminal hydrolase 47", "Ubiquitin carboxyl-terminal hydrolase 5", "Ubiquitin carboxyl-terminal hydrolase 7", "Ubiquitin carboxyl-terminal hydrolase isozyme L5", "Ubiquitin conjugation factor E4 A", "Ubiquitin conjugation factor E4 B", "Ubiquitin thioesterase OTUB1", "Ubiquitin-conjugating enzyme E2 L3", "Ubiquitin-like modifier-activating enzyme 1", "Ubiquitin-like modifier-activating enzyme 6", "Ubiquitin-like modifier-activating enzyme ATG7", "Ubiquitin-like-conjugating enzyme ATG3", "Ubiquitin-protein ligase", "Unclassified protein", "Unconventional myosin-Ib", "Unconventional myosin-Ic", "Unconventional myosin-Id", "Unconventional myosin-VI", "Upstream-binding protein 1", "Uridine kinase family", "Uridine-cytidine kinase 2", "V-type ATPase", "V-type proton ATPase 116 kDa subunit a isoform 1", "V-type proton ATPase 116 kDa subunit a isoform 2", "V-type proton ATPase catalytic subunit A", "V-type proton ATPase subunit B, brain isoform", "V-type proton ATPase subunit C 1", "V-type proton ATPase subunit D", "V-type proton ATPase subunit H", "V-type proton ATPase subunit d 1", "VPS15 family", "VRK family", "Vacuolar protein sorting-associated protein 18 homolog", "Vacuolar protein sorting-associated protein 26A", "Vacuolar protein sorting-associated protein 29", "Vacuolar protein sorting-associated protein 33A", "Vacuolar protein sorting-associated protein 33B", "Vacuolar protein sorting-associated protein 35", "Vacuolar protein sorting-associated protein 4A", "Vacuolar protein sorting-associated protein 4B", "Vacuolar protein sorting-associated protein 52 homolog", "Vacuole membrane protein 1", "Very long-chain specific acyl-CoA dehydrogenase, mitochondrial", "Very-long-chain enoyl-CoA reductase", "Vesicle coat protein", "Vesicle-associated membrane protein 7", "Vesicle-associated membrane protein-associated protein A", "Vesicle-associated membrane protein-associated protein B/C", "Vesicle-fusing ATPase", "Vesicular integral-membrane protein VIP36", "Vitamin K epoxide reductase complex subunit 1-like protein 1", "WASH complex subunit 5", "WD repeat and HMG-box DNA-binding protein 1", "WD repeat-containing protein 1", "WD repeat-containing protein 34", "WD repeat-containing protein 82", "WEE family", "Writer", "X-ray repair cross-complementing protein 5", "X-ray repair cross-complementing protein 6", "Xaa-Pro dipeptidase", "YLP motif-containing protein 1", "YSK subfamily", "Zinc finger CCCH domain-containing protein 11A", "Zinc finger CCCH domain-containing protein 15", "Zinc finger MYM-type protein 2", "Zinc finger RNA-binding protein", "Zinc finger protein 281", "Zinc finger protein 622", "Zinc finger transcription factor", "Zinc transporter 5", "Zinc transporter 6", "Zinc transporter ZIP14", "Zyxin", "[pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial", "c-Myc-binding protein", "eIF-2-alpha kinase activator GCN1", "eukaryotic two domain clade \"e\" sub-subfamily", "m7GpppX diphosphatase", "mRNA export factor", "mRNA polyadenylation factor", "mRNA processing factor", "mRNA splicing factor", "mRNA-decapping enzyme 1B", "rRNA 2'-O-methyltransferase fibrillarin", "tRNA (cytosine(34)-C(5))-methyltransferase"], "available_proteins": ["AARS", "AARS2", "AASDHPPT", "AATF", "ABCB1", "ABCB7", "ABCC1", "ABCD3", "ABCF1", "ABCF2", "ABCF3", "ABHD12", "ABHD6", "ABI1", "ACAA2", "ACAD11", "ACAD9", "ACADM", "ACADVL", "ACAT1", "ACAT2", "ACBD5", "ACLY", "ACO1", "ACO2", "ACOT7", "ACOT9", "ACOX1", "ACOX3", "ACP2", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTR10", "ACTR1A", "ACTR1B", "ACTR2", "ACTR3", "ADAR", "ADD1", "ADD3", "ADH5", "ADI1", "ADPGK", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGL", "AHCY", "AHCYL1", "AIFM1", "AIMP1", "AIP", "AK1", "AK2", "AKR1A1", "AKR1B1", "AKR7A2", "AKT2", "ALDH18A1", "ALDH1B1", "ALDH2", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALG1", "ALG12", "ALYREF", "ANAPC1", "ANGEL1", "ANO6", "ANP32B", "ANP32E", "AP1B1", "AP1G1", "AP1M1", "AP1S2", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "AP3S1", "APEH", "APLP2", "APOL2", "APP", "ARAF", "ARCN1", "ARFIP1", "ARFIP2", "ARHGDIA", "ARID3B", "ARIH1", "ARIH2", "ARPC1A", "ARPC3", "ARPC4", "ARPC5", "ASAH1", "ASNA1", "ASNS", "ATAD2", "ATAD3A", "ATAD3B", "ATG3", "ATG4B", "ATG7", "ATIC", "ATL2", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP6", "ATP6AP2", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1D", "ATP6V1H", "ATP7B", "ATPAF1", "ATPIF1", "ATXN2L", "AUP1", "AURKA", "AURKB", "BAG6", "BAIAP2", "BAK1", "BCAP31", "BCAS2", "BCLAF1", "BLMH", "BLVRA", "BOP1", "BPNT1", "BRD2", "BRIX1", "BUB1B", "BUB3", "BUD23", "BUD31", "BZW1", "BZW2", "CAB39", "CACYBP", "CAD", "CALM3", "CALR", "CALU", "CAMK1", "CAMK2G", "CAND1", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPRIN1", "CAPZA1", "CAPZA2", "CAPZB", "CARM1", "CARS", "CARS2", "CASK", "CBX1", "CBX3", "CBX5", "CCAR1", "CCAR2", "CCNB1", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2BP2", "CDC20", "CDC37", "CDC40", "CDC42", "CDC7", "CDK1", "CDK2", "CDK4", "CDK5", "CDK6", "CEBPZ", "CECR2", "CETN2", "CFAP20", "CHAF1A", "CHAF1B", "CHERP", "CHKA", "CHMP3", "CHMP4B", "CHMP5", "CHMP7", "CHORDC1", "CHRAC1", "CHST14", "CIRBP", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLCC1", "CLCN3", "CLCN7", "CLGN", "CLIC1", "CLIC4", "CLNS1A", "CLPTM1", "CLPTM1L", "CLPX", "CLTA", "CLTC", "CLUH", "CMAS", "CMPK1", "CMSS1", "CNDP2", "CNN3", "CNOT1", "CNOT2", "CNP", "COASY", "COIL", "COLEC12", "COLGALT1", "COMT", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS3", "COPS5", "COPS6", "COPS8", "COPZ1", "CORO1B", "CORO1C", "CORO7", "COTL1", "COX2", "COX5A", "COX5B", "COX7A2", "CPOX", "CPSF1", "CPSF3", "CPSF6", "CPSF7", "CPT1A", "CPT2", "CPVL", "CRNKL1", "CROT", "CRTAP", "CS", "CSE1L", "CSK", "CSNK1A1", "CSNK2A2", "CSNK2B", "CSRP2", "CSTB", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTCF", "CTNNA1", "CTNND1", "CTPS1", "CTPS2", "CTSA", "CTSB", "CTSC", "CTTN", "CUL1", "CUL2", "CUL4B", "CUL5", "CYB5B", "CYB5D2", "CYFIP1", "CYFIP2", "CYP51A1", "DAD1", "DAG1", "DAP3", "DARS", "DARS2", "DBN1", "DBNL", "DBT", "DCAF13", "DCP1B", "DCPS", "DCTD", "DCTN1", "DCTN2", "DDAH2", "DDB1", "DDI2", "DDOST", "DDT", "DENR", "DERL1", "DERL2", "DGKE", "DHCR24", "DHCR7", "DHFR", "DHX15", "DHX29", "DHX37", "DHX38", "DHX40", "DHX57", "DHX8", "DHX9", "DIDO1", "DIS3", "DLD", "DLGAP5", "DLST", "DNM1L", "DNM2", "DNMT1", "DOCK7", "DOLPP1", "DPAGT1", "DPH5", "DPM1", "DPP3", "DPP9", "DPYSL2", "DPYSL5", "DSC3", "DSG2", "DSP", "DST", "DTYMK", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNC1LI2", "DYNLL2", "EARS2", "ECE1", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "EDC4", "EEF1A2", "EEF1B2", "EEF1D", "EEF2", "EFL1", "EFTUD2", "EHD1", "EHD4", "EIF2A", "EIF2AK2", "EIF2D", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3H", "EIF3I", "EIF3J", "EIF3L", "EIF4B", "EIF4E", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELMO2", "ELMOD2", "ELOB", "ELOC", "ELP1", "ELP3", "EMC2", "EMG1", "ENO1", "ENO2", "ENOPH1", "EPHA7", "EPHX2", "EPPK1", "EPRS", "EPS15L1", "ERAL1", "ERAP1", "ERC1", "ERH", "ERMP1", "ERO1A", "ERP29", "ESD", "ESPL1", "ETF1", "ETFA", "ETFB", "ETFDH", "ETNK1", "EWSR1", "EXO1", "EXOC3", "EXOC5", "EXOC6", "EXOC6B", "EXOC7", "EXOSC2", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC9", "EZR", "FAHD1", "FAM177A1", "FARS2", "FARSB", "FASN", "FBL", "FDPS", "FDXR", "FECH", "FEN1", "FH", "FKBP1A", "FKBP4", "FKBP5", "FMR1", "FN3KRP", "FNTA", "FNTB", "FOXRED1", "FSCN1", "FTL", "FUBP1", "FUBP3", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GAK", "GALK1", "GALNT1", "GALNT2", "GALNT4", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GATAD2B", "GBE1", "GCAT", "GCLC", "GCN1", "GDI1", "GDI2", "GFPT1", "GGH", "GINS2", "GLB1", "GLDC", "GLRX3", "GLS", "GLUD1", "GLYR1", "GM2A", "GMFB", "GMPS", "GNA13", "GNAI2", "GNAI3", "GNG12", "GNPDA1", "GNS", "GOLGA2", "GOSR1", "GPAT4", "GPATCH4", "GPD2", "GPI", "GPKOW", "GPR107", "GPR89B", "GPT2", "GRHPR", "GRPEL1", "GRSF1", "GSPT1", "GSR", "GSS", "GTF2B", "GTF2F1", "GTF3C3", "GTPBP1", "GUF1", "GYG1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACL1", "HADHA", "HADHB", "HAT1", "HBS1L", "HCCS", "HDAC1", "HDAC2", "HDGF", "HDGFL2", "HDHD2", "HDHD5", "HEATR1", "HEATR6", "HEXA", "HEXB", "HIBADH", "HIBCH", "HINT2", "HINT3", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HM13", "HMBS", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMGCL", "HMGN2", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPM", "HNRNPR", "HPRT1", "HSD17B10", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPE1", "HTATSF1", "HUWE1", "IARS", "IARS2", "IDE", "IDH3A", "IDH3B", "IDI1", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IK", "IKBKG", "ILF3", "ILK", "ILKAP", "ILVBL", "IMP3", "IMP4", "IMPA1", "IMPAD1", "IMPDH1", "IMPDH2", "INTS11", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IQGAP2", "ITCH", "ITGB1", "ITPA", "IVD", "KARS", "KAT7", "KCTD12", "KDELR1", "KDM1A", "KDM1B", "KDM3B", "KHDRBS1", "KHSRP", "KIF11", "KIF14", "KIF15", "KIF18B", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF4A", "KIF5B", "KIFC1", "KPNA1", "KPNA2", "KPNA3", "KPNA6", "KPNB1", "KRR1", "L2HGDH", "LAMP1", "LAMP2", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS2", "LBR", "LDHA", "LDHB", "LETM1", "LGMN", "LIG1", "LIG3", "LIMA1", "LIPA", "LMAN2", "LNPEP", "LONP1", "LPCAT1", "LPCAT3", "LRRC47", "LRWD1", "LSM2", "LSM3", "LSM4", "LSM6", "LSM7", "M6PR", "MACF1", "MAGED2", "MAGT1", "MAN1A1", "MAP1B", "MAP1S", "MAP2K2", "MAPK1", "MAPK14", "MAPRE1", "MAPRE2", "MARCH5", "MASTL", "MAT2A", "MBOAT7", "MCCC1", "MCCC2", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCTS1", "MCU", "MDH1", "MDH2", "ME1", "ME2", "MECP2", "MED21", "MED25", "METTL14", "METTL7A", "METTL7B", "MFN1", "MFN2", "MFSD3", "MFSD5", "MGST2", "MGST3", "MIA2", "MIA3", "MICU1", "MICU2", "MIPEP", "MKRN2", "MMS19", "MOB4", "MORF4L1", "MPC2", "MPG", "MPHOSPH10", "MPI", "MPP1", "MPP6", "MPRIP", "MPST", "MPV17", "MPV17L2", "MRPL1", "MRPL11", "MRPL12", "MRPL14", "MRPL17", "MRPL19", "MRPL21", "MRPL22", "MRPL23", "MRPL24", "MRPL38", "MRPL39", "MRPL44", "MRPL9", "MRPS11", "MRPS16", "MRPS18A", "MRPS27", "MRPS35", "MRPS5", "MRPS7", "MRRF", "MSH2", "MSH3", "MSH6", "MSMO1", "MSN", "MTA1", "MTA2", "MTAP", "MTCH1", "MTCH2", "MTHFD1", "MTHFD1L", "MTHFD2", "MTMR2", "MTOR", "MTPAP", "MUT", "MVK", "MYBBP1A", "MYCBP", "MYEF2", "MYL6", "MYO1B", "MYO1C", "MYO1D", "MYO6", "NAA15", "NAA25", "NAA35", "NAA50", "NADK2", "NAE1", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NARS", "NCAPD2", "NCAPD3", "NCBP1", "NCL", "ND1", "NDUFA13", "NDUFA4", "NDUFA5", "NDUFA8", "NDUFA9", "NDUFB1", "NDUFB4", "NDUFB5", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS6", "NDUFS7", "NDUFS8", "NEK9", "NHP2", "NKRF", "NLN", "NLRX1", "NME1", "NMT1", "NNT", "NOC4L", "NOL6", "NOM1", "NONO", "NOP14", "NOP56", "NOP58", "NOP9", "NPEPPS", "NPM1", "NRDC", "NSD2", "NSDHL", "NSF", "NSUN2", "NT5C2", "NT5C3B", "NT5DC1", "NT5DC2", "NTHL1", "NTMT1", "NTPCR", "NUCB1", "NUCB2", "NUDC", "NUDCD2", "NUDT1", "NUDT21", "NUDT5", "NUDT9", "NUF2", "NUP107", "NUP153", "NUP160", "NUP210", "NUP214", "NUP37", "NUP54", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NXF1", "OAT", "OCIAD1", "OCLN", "OCRL", "OLA1", "OPA1", "OSGEP", "OTUB1", "OTUD4", "OTUD7B", "OXA1L", "OXCT1", "OXSR1", "P3H1", "P3H4", "PACSIN2", "PAICS", "PAIP1", "PAK2", "PANK4", "PAPOLA", "PARG", "PARK7", "PARN", "PATL1", "PBK", "PBRM1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCK2", "PCMT1", "PCNA", "PDCD11", "PDCD5", "PDCD6IP", "PDE12", "PDE6D", "PDK3", "PDLIM1", "PDLIM5", "PDLIM7", "PDPR", "PDS5A", "PDS5B", "PDXK", "PEBP1", "PECR", "PELO", "PEPD", "PES1", "PEX14", "PEX19", "PEX5", "PFDN2", "PFDN5", "PFKL", "PFKM", "PFKP", "PGD", "PGK1", "PGLS", "PGP", "PGRMC1", "PGRMC2", "PHAX", "PHC2", "PHF6", "PHGDH", "PHIP", "PHKA1", "PI4K2A", "PI4KB", "PICALM", "PIGK", "PIK3R4", "PINX1", "PIP4K2C", "PIR", "PITPNB", "PITRM1", "PKM", "PKMYT1", "PKN1", "PKN2", "PLA2G15", "PLAA", "PLBD2", "PLCG1", "PLD6", "PLEC", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLS3", "PM20D2", "PMPCA", "PMPCB", "PNP", "PNPLA6", "PNPT1", "POGZ", "POLA2", "POLD2", "POLDIP3", "POLE4", "POLR1A", "POLR1B", "POLR1C", "POLR2A", "POLR2B", "POLR2C", "POLR2D", "POLR2E", "POLR2F", "POLR2G", "POLR2L", "POLR3A", "POLR3C", "POLRMT", "PPA1", "PPA2", "PPAT", "PPIL1", "PPIL3", "PPM1G", "PPME1", "PPP1CA", "PPP1CB", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP2R5E", "PPP4R1", "PPP6R3", "PPT1", "PPT2", "PPWD1", "PRC1", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX6", "PREB", "PREP", "PRIM1", "PRKAA2", "PRKACA", "PRKAG1", "PRKCB", "PRKCSH", "PRKDC", "PRKRA", "PRMT1", "PRMT3", "PRMT5", "PRPF31", "PRPF39", "PRPF4", "PRPF4B", "PRPF6", "PRPF8", "PRPSAP1", "PRPSAP2", "PRRC2A", "PRRC2C", "PRTFDC1", "PSIP1", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD7", "PSMD8", "PSMD9", "PSPC1", "PTDSS1", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK7", "PTPA", "PTPRF", "PUDP", "PUM1", "PURA", "PWP1", "PXMP2", "PXN", "PYGB", "PYGL", "QARS", "QKI", "QRSL1", "QSOX2", "RAB3GAP2", "RABAC1", "RABGAP1", "RAC1", "RACGAP1", "RAD23A", "RAD23B", "RAE1", "RALA", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP6", "RANBP9", "RANGAP1", "RAP2B", "RAPGEF2", "RAVER1", "RBBP6", "RBM12", "RBM14", "RBM17", "RBM19", "RBM22", "RBM26", "RBM27", "RBM4", "RBMX", "RCL1", "RCN1", "RCN2", "RDH11", "RDH14", "RDX", "RECQL", "REEP4", "REEP5", "RFC2", "RFC3", "RFC4", "RFC5", "RHBDD2", "RHEB", "RHOG", "RHOT1", "RHOT2", "RNASEH2A", "RNF14", "RNH1", "ROCK1", "RPA1", "RPF1", "RPF2", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL18", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL38", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPN1", "RPN2", "RPP30", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15A", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RRM1", "RRM2", "RRS1", "RSL1D1", "RSL24D1", "S100A11", "S100A13", "SAE1", "SAP18", "SARS", "SARS2", "SART1", "SART3", "SBDS", "SCAF4", "SCAMP1", "SCAMP2", "SCAMP3", "SCARB1", "SCARB2", "SCFD1", "SCML2", "SCO1", "SCO2", "SCPEP1", "SDCBP", "SDF4", "SDHA", "SDHB", "SDR39U1", "SEC11A", "SEC23A", "SEC23B", "SEC23IP", "SEC24A", "SEC24B", "SEC24C", "SEC24D", "SEC31A", "SEC61A1", "SEC63", "SEH1L", "SENP3", "SEPHS1", "SEPT11", "SEPT2", "SEPT6", "SEPT7", "SEPT9", "SERBP1", "SERPINB6", "SERPINH1", "SET", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B3", "SFPQ", "SFXN1", "SFXN2", "SHMT1", "SHMT2", "SIN3A", "SIRT1", "SKP1", "SLC12A9", "SLC16A1", "SLC19A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A17", "SLC25A19", "SLC25A20", "SLC25A21", "SLC25A22", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A33", "SLC25A4", "SLC25A40", "SLC25A42", "SLC25A5", "SLC25A6", "SLC27A4", "SLC30A5", "SLC30A6", "SLC33A1", "SLC35B2", "SLC35F2", "SLC39A14", "SLC3A2", "SLC4A7", "SLC6A15", "SLK", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMN1*", "SMYD3", "SNAP23", "SND1", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNW1", "SNX1", "SNX19", "SNX2", "SOAT1", "SOD2", "SORD", "SPAG9", "SPCS2", "SPHK2", "SPNS1", "SPTLC1", "SPTLC2", "SQLE", "SREK1", "SRM", "SRP14", "SRP54", "SRP68", "SRP9", "SRPK1", "SRPK2", "SRPRA", "SRRM1", "SRSF1", "SRSF10", "SRSF11", "SRSF3", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSR1", "STAG1", "STAG2", "STAMBP", "STAT1", "STAT3", "STK26", "STK4", "STOM", "STOML2", "STRBP", "STT3A", "STT3B", "STX10", "STX12", "STX18", "STX3", "STX4", "STX5", "STX7", "STX8", "STXBP3", "SUCLA2", "SUCLG2", "SUGP1", "SUGP2", "SUN1", "SUN2", "SUPT16H", "SUPT6H", "SURF4", "SURF6", "SUZ12", "SV2A", "SYNCRIP", "SYNGR2", "SYNJ2BP", "SYS1", "TAB1", "TAF15", "TAF6L", "TAGLN2", "TAOK1", "TAP1", "TARS", "TARS2", "TBC1D13", "TBC1D15", "TBC1D2B", "TBC1D4", "TBC1D9B", "TBCA", "TBCB", "TBCD", "TBCE", "TCEA1", "TCERG1", "TCP1", "TDRKH", "TECR", "TES", "TFCP2", "TFIP11", "TFRC", "TGOLN2", "THOC1", "THOC2", "THOC3", "THOP1", "THRAP3", "TIMM10B", "TJP1", "TK1", "TKT", "TM9SF2", "TM9SF3", "TM9SF4", "TMED10", "TMED2", "TMED4", "TMED5", "TMED7", "TMED9", "TMEM165", "TMEM259", "TMEM38B", "TMEM97", "TMOD1", "TMOD3", "TMPO", "TNPO1", "TNPO2", "TNPO3", "TOE1", "TOMM20", "TOMM40", "TOP1", "TOR1B", "TOR3A", "TP53", "TPI1", "TPM1", "TPM3", "TPM4", "TPP1", "TPP2", "TPT1", "TPX2", "TRA2A", "TRA2B", "TRAF2", "TRAP1", "TROVE2", "TRUB1", "TSFM", "TSG101", "TST", "TTK", "TTYH3", "TUBB", "TUBB2A", "TUBB2B", "TUBB3", "TUBB4B", "TUBB6", "TUBGCP2", "TUBGCP3", "TUBGCP4", "TUFM", "TWF1", "TWF2", "TWISTNB", "TWNK", "TXLNA", "TXLNG", "TXNDC12", "TXNDC17", "TXNDC9", "TXNRD1", "TYMS", "U2AF1", "U2SURP", "UBA1", "UBA2", "UBA3", "UBA6", "UBE2L3", "UBE4A", "UBE4B", "UBP1", "UCHL5", "UCK2", "UGCG", "UGGT1", "ULK3", "UNC119", "UNC119B", "UPF1", "UQCR10", "UQCRB", "UQCRC1", "UQCRC2", "USO1", "USP10", "USP11", "USP14", "USP28", "USP36", "USP39", "USP47", "USP5", "USP7", "UTP11", "UTP14A", "UTP3", "UTP6", "VAMP7", "VAPA", "VAPB", "VBP1", "VKORC1L1", "VMP1", "VPS18", "VPS26A", "VPS29", "VPS33A", "VPS33B", "VPS35", "VPS4A", "VPS4B", "VPS52", "VRK1", "VRK3", "WARS", "WASHC5", "WDHD1", "WDR1", "WDR34", "WDR82", "WIZ", "XAB2", "XPO1", "XPO4", "XPO5", "XPO7", "XPOT", "XRCC5", "XRCC6", "YARS", "YARS2", "YLPM1", "YME1L1", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2", "ZC3H11A", "ZC3H15", "ZFR", "ZMPSTE24", "ZMYM2", "ZNF207", "ZNF281", "ZNF622", "ZW10", "ZYX"], "leading_proteins": ["ABCB1", "ABCB7", "ABCC1", "ABCD3", "ABHD12", "ACAT2", "ACOX1", "ACOX3", "AIFM1", "ALDH5A1", "ALG1", "ALG12", "ANO6", "AP2M1", "AP3M1", "APLP2", "APOL2", "APP", "ATP1A1", "ATP2A2", "ATP2B1", "ATP5B", "ATP5F1", "ATP5I", "ATP6", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP7B", "AURKA", "AURKB", "BCAP31", "BUB1B", "CALU", "CAMK1", "CARM1", "CBX1", "CDC42", "CDC7", "CDK4", "CHST14", "CLCC1", "CLCN3", "CLCN7", "CLPTM1", "CLPTM1L", "COMT", "COX2", "COX7A2", "CPT2", "CPVL", "CRTAP", "CSE1L", "CTSA", "CYB5B", "CYB5D2", "CYP51A1", "DERL1", "DERL2", "DHCR24", "DHCR7", "DHFR", "DLD", "DNM1L", "DNM2", "DPAGT1", "ECE1", "EIF2AK2", "ELMOD2", "ERAL1", "ERAP1", "FAM177A1", "FASN", "FNTA", "FOXRED1", "FUBP3", "GAK", "GALNT4", "GM2A", "GOSR1", "HCCS", "HK1", "ILVBL", "IPO11", "IPO7", "IPO8", "IPO9", "KDELR1", "KPNA2", "KPNA3", "L2HGDH", "LAMP1", "LAMP2", "LBR", "LETM1", "LMAN2", "LNPEP", "LPCAT1", "MAGT1", "MBOAT7", "MCL1", "METTL7A", "MFSD3", "MIA2", "MICU2", "MIPEP", "MPG", "MPV17L2", "MSMO1", "MTAP", "MTCH1", "MTCH2", "NAMPT", "NAP1L1", "ND1", "NDUFA13", "NDUFB1", "NDUFB4", "NDUFB9", "NEK9", "NLN", "NLRX1", "NNT", "NPEPPS", "NSD2", "NT5C3B", "NTMT1", "NUCB1", "NUCB2", "OPA1", "OXA1L", "P3H1", "P3H4", "PBK", "PECR", "PEX5", "PGRMC1", "PGRMC2", "PI4KB", "PITRM1", "PKMYT1", "PLD6", "PLK1", "PMPCA", "PPT1", "PPT2", "PRCP", "PRMT3", "PRMT5", "PXMP2", "RABAC1", "RAC1", "RALA", "RAN", "RAP2B", "RCN2", "REEP4", "REEP5", "RHBDD2", "RHEB", "RHOG", "RHOT1", "RHOT2", "RPS6KA3", "S100A13", "SCAMP2", "SCARB1", "SCARB2", "SCFD1", "SCO1", "SCO2", "SCPEP1", "SDCBP", "SDF4", "SDHB", "SEC11A", "SEH1L", "SEPT11", "SEPT2", "SEPT6", "SEPT7", "SET", "SFXN1", "SFXN2", "SLC16A1", "SLC19A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A17", "SLC25A19", "SLC25A20", "SLC25A21", "SLC25A22", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A33", "SLC25A4", "SLC25A40", "SLC25A42", "SLC25A5", "SLC25A6", "SLC30A5", "SLC30A6", "SLC33A1", "SLC35B2", "SLC35F2", "SLC39A14", "SLC4A7", "SLC6A15", "SMN1*", "SMYD3", "SOAT1", "SPTLC1", "SQLE", "SSR1", "STOM", "STOML2", "STT3A", "STX10", "STX12", "STX18", "STX4", "STX5", "STX7", "STX8", "SURF4", "SV2A", "SYNGR2", "SYNJ2BP", "SYS1", "TAP1", "TECR", "TFRC", "TGOLN2", "TIMM10B", "TM9SF2", "TM9SF3", "TM9SF4", "TMED10", "TMED2", "TMED7", "TMED9", "TMEM165", "TNPO1", "TOMM20", "TOMM40", "TPP1", "TTK", "TTYH3", "TXNDC12", "UGCG", "ULK3", "UNC119", "UNC119B", "UQCR10", "UQCRC1", "UQCRC2", "VKORC1L1", "VPS18", "VPS52", "WASHC5", "YME1L1", "ZADH2", "ZMPSTE24"]} \ No newline at end of file diff --git a/pharos_protein_category/advanced/idx2term.json b/pharos_protein_category/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..9e26dfeeb6e641a33dae4961196235bdb965b21b --- /dev/null +++ b/pharos_protein_category/advanced/idx2term.json @@ -0,0 +1 @@ +{} \ No newline at end of file diff --git a/pharos_protein_category/basic/idx2term.json b/pharos_protein_category/basic/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..a0739b7a1518393d576dba30d8ec5942decce175 --- /dev/null +++ b/pharos_protein_category/basic/idx2term.json @@ -0,0 +1 @@ +{"0": "Tclin", "1": "Tdark"} \ No newline at end of file diff --git a/pharos_protein_category/basic/plot_0.png b/pharos_protein_category/basic/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..d018405832254e3c893b6d09933fcb35c8a91ee8 --- /dev/null +++ b/pharos_protein_category/basic/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:85ce5da8a2f93c272db8741cd6ca8b9e80c321da99875b4736a50134b7f150ff +size 130740 diff --git a/pharos_protein_category/basic/plot_1.png b/pharos_protein_category/basic/plot_1.png new file mode 100644 index 0000000000000000000000000000000000000000..a54165c72f1fba50ec750c51b68eaf23131acb4e --- /dev/null +++ b/pharos_protein_category/basic/plot_1.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:00b66b6e218cbad7404ad77ace979887625ea9cfa2cbbc8571d09aebe697c5c5 +size 137719 diff --git a/pharos_protein_category/consensus.joblib b/pharos_protein_category/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..94cd11652ca900ccf1df77522d93ba6a0051d584 --- /dev/null +++ b/pharos_protein_category/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:e42ebbb8605caf7f7e8fb161d8d267141059da479e084693687e8e635b7333a0 +size 74651 diff --git a/pharos_protein_category/df_merge.tsv b/pharos_protein_category/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..c57981107d970e936c6c67aa07afef8fff633223 --- /dev/null +++ b/pharos_protein_category/df_merge.tsv @@ -0,0 +1 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 diff --git a/pharos_protein_category/metrics.json b/pharos_protein_category/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..52912b748026a0662d19d8e5f6d645a4564ff19d --- /dev/null +++ b/pharos_protein_category/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2974, + "annotations_size": 4, + "title": "Average number of proteins per term", + "value": 743.25 +} \ No newline at end of file diff --git a/pharos_protein_category/paths.json b/pharos_protein_category/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..62579badef2a4ee5955b5911ae7c7a8ab6e901e2 --- /dev/null +++ b/pharos_protein_category/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/pharos_protein_category/fragment/C220/C220_val_log2fc"} \ No newline at end of file diff --git a/pharos_protein_category/result.tsv b/pharos_protein_category/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..474b92a31534958db37af975f88561ed8efab756 --- /dev/null +++ b/pharos_protein_category/result.tsv @@ -0,0 +1,3 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Tclin 0.3667868205446573 1.613527972477581 0.1066298510852505 0.3630200719876458 0.2132597021705011 83 Q86Y39,P05023,O96000,O95139,Q9Y6M9,O43676,Q7L0J3,O75438,O43924,P38435,P49721,Q9P0J0,P06280,P10253,Q16739,P03886,O95168,P62942,P21964 19 +Tdark 0.4198133240821214 0.6984478515000847 0.4848971597857838 0.9295994944030872 0.4848971597857838 294 O60830,P14406,Q9BVG4,Q69YU5,Q15006,Q86VR2,Q8IXU6,Q96CP7,Q9Y2W6,O75964,Q8N4H5,Q9Y5M8,Q9NX00,Q96NB2,Q6PI78,Q15629,O94919,Q6ZT21,P62312,Q9HD45,P60059,Q5VW38,Q8N5N7,Q8TBQ9,Q9Y3E0,Q9NU23,Q8N2H4,Q3SXM5,Q5R3I4,Q96ES6,Q86YN1,Q8NBN3,Q5THJ4,Q8IUX1,Q9NR77,Q9NXF7,O95302,Q9NQE9,Q9H1E5,Q9H9B4,P82933,Q9H1Z9,Q9Y6X3,Q7Z6M1,Q05D32,Q7Z3D4,P0CG08,Q6ZXV5,Q5TC12,Q96M27,Q96LJ7,Q9P0S9,Q9H4I3,Q96GQ5,Q96DX4,Q6YN16,Q9HD20,Q92575,Q8WZA9,Q969T7,Q9Y4W2,Q96CN7,Q9NRY5,O75071,Q8WVC6,Q9H857,Q9BSJ2,Q9NVS2,Q9BVK6,Q6UW02,Q8NBN7,Q8N128,Q6NUQ4,Q6UW68,Q9Y5J6,O95070,Q5SNT2,Q9NUQ9,Q70UQ0,Q8N8L6,Q5J8M3,O75935,Q9NX62,L0R6Q1,Q9H1A3,Q9NPA0,Q99805,Q9Y320,Q15005,Q9NW68,A4D1U4,Q96SK2,Q9Y3B3,Q9BRJ2,Q8N6S5,Q9BWH2,Q9BU23,O43615,Q8WWC4,Q8WUJ1,Q96ND0,Q8IYS2,Q9Y6I9,Q9Y6J9,Q9NUD5,A0AVF1 106 diff --git a/pharos_protein_category/selections.json b/pharos_protein_category/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..d704c031f016171a758a7011c47a0da4c703e4fa --- /dev/null +++ b/pharos_protein_category/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["Tbio", "Tchem", "Tclin", "Tdark"], "available_proteins": ["AAAS", "AAMP", "AAR2", "AARS", "AARS2", "AASDHPPT", "AASS", "AATF", "ABCB1", "ABCB7", "ABCC1", "ABCD3", "ABCE1", "ABCF1", "ABCF2", "ABCF3", "ABHD10", "ABHD12", "ABHD14B", "ABHD6", "ABI1", "ACAA2", "ACACA", "ACACB", "ACAD11", "ACAD9", "ACADM", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACBD5", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT9", "ACOX1", "ACOX3", "ACP1", "ACP2", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN4", "ACTR10", "ACTR1A", "ACTR1B", "ACTR2", "ACTR3", "ADAR", "ADD1", "ADD3", "ADH5", "ADI1", "ADNP", "ADPGK", "ADPRHL2", "ADRM1", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGK", "AGL", "AGPAT1", "AGPAT5", "AGPS", "AHCY", "AHCYL1", "AHNAK", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AKAP12", "AKAP13", "AKAP8", "AKAP8L", "AKR1A1", "AKR1B1", "AKR7A2", "AKT2", "ALDH18A1", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALG1", "ALG11", "ALG12", "ALKBH5", "ALYREF", "AMOT", "ANAPC1", "ANAPC16", "ANAPC2", "ANAPC5", "ANAPC7", "ANGEL1", "ANKFY1", "ANKHD1", "ANKLE2", "ANKRD17", "ANO10", "ANO6", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA3", "ANXA4", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP1M1", "AP1S2", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "AP3S1", "APEH", "APEX1", "API5", "APLP2", "APMAP", "APOL2", "APOO", "APOOL", "APP", "APRT", "AQR", "ARAF", "ARCN1", "ARF4", "ARF6", "ARFGAP1", "ARFGAP2", "ARFIP1", "ARFIP2", "ARGLU1", "ARHGAP1", "ARHGAP17", "ARHGDIA", "ARHGEF1", "ARHGEF2", "ARID1A", "ARID3B", "ARIH1", "ARIH2", "ARL1", "ARL10", "ARL2", "ARL3", "ARL6IP1", "ARL6IP5", "ARL6IP6", "ARMC10", "ARMC6", "ARMC8", "ARMCX3", "ARMT1", "ARPC1A", "ARPC2", "ARPC3", "ARPC4", "ARPC5", "ASAH1", "ASCC2", "ASCC3", "ASNA1", "ASNS", "ASPH", "ATAD1", "ATAD2", "ATAD3A", "ATAD3B", "ATE1", "ATG3", "ATG4B", "ATG7", "ATG9A", "ATIC", "ATL2", "ATP13A1", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6", "ATP6AP1", "ATP6AP2", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1D", "ATP6V1E1", "ATP6V1H", "ATP7B", "ATPAF1", "ATPIF1", "ATRIP", "ATXN10", "ATXN2L", "AUP1", "AURKA", "AURKB", "B3GALT6", "B4GAT1", "BABAM1", "BAG2", "BAG4", "BAG5", "BAG6", "BAIAP2", "BAK1", "BANF1", "BANP", "BASP1", "BAZ1A", "BAZ1B", "BCAP31", "BCAS2", "BCCIP", "BCL2L13", "BCLAF1", "BCS1L", "BICD2", "BIRC6", "BLMH", "BLVRA", "BMS1", "BNIP1", "BOD1", "BOLA2*", "BOP1", "BPHL", "BPNT1", "BRAP", "BRAT1", "BRD2", "BRI3BP", "BRIX1", "BSDC1", "BSG", "BTAF1", "BTF3", "BUB1B", "BUB3", "BUD23", "BUD31", "BYSL", "BZW1", "BZW2", "C11orf58", "C12orf73", "C16orf58", "C17orf75", "C19orf70", "C1QBP", "C1orf35", "C21orf59", "C2CD5", "C5orf51", "CAB39", "CACUL1", "CACYBP", "CAD", "CALD1", "CALM3", "CALR", "CALU", "CAMK1", "CAMK2G", "CAND1", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPRIN1", "CAPZA1", "CAPZA2", "CAPZB", "CARM1", "CARS", "CARS2", "CASK", "CAST", "CBR1", "CBX1", "CBX3", "CBX5", "CBX8", "CCAR1", "CCAR2", "CCDC124", "CCDC134", "CCDC138", "CCDC22", "CCDC47", "CCDC6", "CCDC86", "CCNB1", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2AP", "CD2BP2", "CD320", "CD47", "CDC123", "CDC16", "CDC20", "CDC23", "CDC27", "CDC34", "CDC37", "CDC40", "CDC42", "CDC5L", "CDC7", "CDC73", "CDCA2", "CDCA8", "CDH2", "CDIPT", "CDK1", "CDK2", "CDK4", "CDK5", "CDK5RAP3", "CDK6", "CDKAL1", "CDKN2A", "CDS2", "CEBPZ", "CECR2", "CELF2", "CENPI", "CENPP", "CENPV", "CEP290", "CEP44", "CEP55", "CERS1", "CERS2", "CETN2", "CFAP20", "CFL1", "CFL2", "CHAC2", "CHAF1A", "CHAF1B", "CHAMP1", "CHCHD3", "CHD1", "CHD1L", "CHD4", "CHERP", "CHID1", "CHKA", "CHMP1A", "CHMP2A", "CHMP2B", "CHMP3", "CHMP4B", "CHMP5", "CHMP7", "CHORDC1", "CHRAC1", "CHST14", "CHTF18", "CIAPIN1", "CIP2A", "CIRBP", "CISD1", "CISD2", "CKAP2", "CKAP4", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLCC1", "CLCN3", "CLCN7", "CLGN", "CLIC1", "CLIC4", "CLINT1", "CLN5", "CLNS1A", "CLPB", "CLPP", "CLPTM1", "CLPTM1L", "CLPX", "CLTA", "CLTC", "CLU", "CLUH", "CMAS", "CMPK1", "CMSS1", "CMTR1", "CNDP2", "CNN3", "CNNM3", "CNNM4", "CNOT1", "CNOT10", "CNOT11", "CNOT2", "CNOT9", "CNP", "CNPY2", "COA3", "COA7", "COASY", "COG3", "COG4", "COIL", "COLEC12", "COLGALT1", "COMMD1", "COMT", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS7A", "COPS8", "COPZ1", "COQ8A", "COQ9", "CORO1B", "CORO1C", "CORO7", "COTL1", "COX18", "COX4I1", "COX5A", "COX5B", "COX6C", "COX7A2", "CPD", "CPNE1", "CPNE3", "CPOX", "CPSF1", "CPSF2", "CPSF3", "CPSF6", "CPSF7", "CPT1A", "CPT2", "CPVL", "CRK", "CRKL", "CRNKL1", "CROT", "CRTAP", "CRYZL1", "CS", "CSDE1", "CSE1L", "CSK", "CSNK1A1", "CSNK2A2", "CSNK2B", "CSRP2", "CSTB", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTCF", "CTDSPL2", "CTNNA1", "CTNNAL1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTPS2", "CTR9", "CTSA", "CTSB", "CTSC", "CTTN", "CTTNBP2NL", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CUTA", "CWC15", "CWC27", "CWF19L1", "CXorf56", "CXorf57", "CYB5B", "CYB5D2", "CYB5R1", "CYB5R3", "CYC1", "CYFIP1", "CYFIP2", "CYP20A1", "CYP51A1", "DAD1", "DAG1", "DAP3", "DARS", "DARS2", "DAXX", "DAZAP1", "DBN1", "DBNL", "DBT", "DCAF13", "DCAF16", "DCAF7", "DCAKD", "DCD", "DCP1B", "DCPS", "DCTD", "DCTN1", "DCTN2", "DCTN3", "DCTN4", "DCTPP1", "DCUN1D1", "DCUN1D5", "DCXR", "DDAH2", "DDB1", "DDI2", "DDOST", "DDRGK1", "DDT", "DDX1", "DDX10", "DDX17", "DDX18", "DDX20", "DDX21", "DDX23", "DDX24", "DDX27", "DDX28", "DDX39A", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX50", "DDX51", "DDX52", "DDX54", "DDX55", "DDX56", "DDX6", "DEGS1", "DEK", "DENR", "DERL1", "DERL2", "DFFA", "DGKE", "DHCR24", "DHCR7", "DHFR", "DHPS", "DHRS1", "DHRS4", "DHRS7", "DHRS7B", "DHX15", "DHX16", "DHX29", "DHX30", "DHX36", "DHX37", "DHX38", "DHX40", "DHX57", "DHX8", "DHX9", "DIABLO", "DIAPH1", "DIAPH2", "DIAPH3", "DIDO1", "DIMT1", "DIS3", "DKC1", "DLAT", "DLD", "DLG3", "DLGAP5", "DLST", "DNAAF5", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC13", "DNAJC19", "DNAJC2", "DNAJC3", "DNAJC7", "DNAJC8", "DNAJC9", "DNM1L", "DNM2", "DNMT1", "DNPH1", "DNTTIP2", "DOCK7", "DOHH", "DOLPP1", "DPAGT1", "DPH2", "DPH5", "DPM1", "DPP3", "DPP9", "DPYSL2", "DPYSL5", "DRG1", "DRG2", "DSC3", "DSG2", "DSP", "DST", "DSTN", "DTYMK", "DUSP12", "DUSP3", "DUSP9", "DUT", "DYM", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNC1LI2", "DYNLL2", "EARS2", "EBNA1BP2", "ECD", "ECE1", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "ECSIT", "EDC3", "EDC4", "EDF1", "EDRF1", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EFCAB14", "EFL1", "EFTUD2", "EHD1", "EHD4", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B5", "EIF2D", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAC2", "ELAVL1", "ELMO2", "ELMOD2", "ELOA", "ELOB", "ELOC", "ELP1", "ELP2", "ELP3", "EMC1", "EMC2", "EMC4", "EMC7", "EMD", "EMG1", "EML4", "ENAH", "ENDOD1", "ENO1", "ENO2", "ENOPH1", "EPB41", "EPB41L2", "EPB41L3", "EPB41L5", "EPDR1", "EPHA7", "EPHX1", "EPHX2", "EPPK1", "EPRS", "EPS15L1", "ERAL1", "ERAP1", "ERC1", "ERCC2", "ERCC3", "ERCC6L", "ERGIC2", "ERGIC3", "ERH", "ERLIN1", "ERLIN2", "ERMP1", "ERO1A", "ERP29", "ERP44", "ESD", "ESF1", "ESPL1", "ESYT1", "ESYT2", "ETF1", "ETFA", "ETFB", "ETFDH", "ETNK1", "EWSR1", "EXO1", "EXOC2", "EXOC3", "EXOC5", "EXOC6", "EXOC6B", "EXOC7", "EXOC8", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC9", "EZR", "F11R", "FABP5", "FADS2", "FAF1", "FAF2", "FAH", "FAHD1", "FAM114A2", "FAM162A", "FAM177A1", "FAM192A", "FAM208A", "FAM210A", "FAM213A", "FAM3C", "FAM49B", "FAM50A", "FAM98A", "FAM98B", "FANCD2", "FANCI", "FAR1", "FARP1", "FARS2", "FARSA", "FARSB", "FASN", "FASTKD2", "FAU", "FBL", "FBXO21", "FBXO22", "FCGRT", "FDFT1", "FDPS", "FDXR", "FECH", "FEN1", "FERMT2", "FGFR1OP", "FH", "FHL1", "FHOD1", "FIP1L1", "FIS1", "FKBP10", "FKBP14", "FKBP1A", "FKBP2", "FKBP3", "FKBP4", "FKBP5", "FKBP7", "FKBP8", "FKBP9", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FMR1", "FN3KRP", "FNTA", "FNTB", "FOXRED1", "FSCN1", "FTL", "FTO", "FTSJ3", "FUBP1", "FUBP3", "FUCA1", "FUCA2", "FUNDC2", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GADD45GIP1", "GAK", "GAL", "GALK1", "GALNT1", "GALNT2", "GALNT4", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GATAD2B", "GBA", "GBE1", "GBF1", "GCAT", "GCC2", "GCDH", "GCLC", "GCN1", "GDAP1", "GDI1", "GDI2", "GDPD1", "GEMIN4", "GEMIN5", "GET4", "GFM1", "GFPT1", "GGCT", "GGCX", "GGH", "GGPS1", "GHDC", "GHITM", "GIGYF2", "GINS2", "GINS3", "GINS4", "GLA", "GLB1", "GLDC", "GLG1", "GLMN", "GLO1", "GLOD4", "GLRX3", "GLS", "GLT8D1", "GLUD1", "GLYR1", "GM2A", "GMFB", "GMPPB", "GMPS", "GNA13", "GNAI2", "GNAI3", "GNG12", "GNL2", "GNL3", "GNL3L", "GNPAT", "GNPDA1", "GNS", "GOLGA2", "GOLGA3", "GOLGA5", "GOLGB1", "GOLIM4", "GOLM1", "GOLPH3", "GOLT1B", "GOPC", "GORASP2", "GOSR1", "GOT1", "GOT2", "GPAA1", "GPAM", "GPAT4", "GPATCH4", "GPATCH8", "GPD2", "GPHN", "GPI", "GPKOW", "GPR107", "GPR89B", "GPS1", "GPT2", "GRAMD1A", "GRB2", "GRHPR", "GRIPAP1", "GRPEL1", "GRSF1", "GRWD1", "GSPT1", "GSR", "GSS", "GSTK1", "GSTM3", "GSTO1", "GTF2B", "GTF2E1", "GTF2F1", "GTF2I", "GTF3C1", "GTF3C2", "GTF3C3", "GTPBP1", "GTPBP10", "GTPBP3", "GTPBP4", "GUF1", "GYG1", "GYS1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACD2", "HACD3", "HACL1", "HADH", "HADHA", "HADHB", "HAT1", "HAUS1", "HAUS3", "HAUS4", "HAUS5", "HBS1L", "HCCS", "HCFC1", "HDAC1", "HDAC2", "HDGF", "HDGFL2", "HDHD2", "HDHD5", "HDLBP", "HEATR1", "HEATR3", "HEATR6", "HEBP1", "HEBP2", "HECTD1", "HELLS", "HEXA", "HEXB", "HGH1", "HGS", "HIBADH", "HIBCH", "HIKESHI", "HINT2", "HINT3", "HIRIP3", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLTF", "HM13", "HMBS", "HMCES", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMGCL", "HMGCR", "HMGCS1", "HMGN2", "HMMR", "HMOX1", "HMOX2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPLL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HNRNPUL2", "HP1BP3", "HPRT1", "HPS6", "HS2ST1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSDL1", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA13", "HSPA14", "HSPA1B", "HSPA2", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPB1", "HSPBP1", "HSPD1", "HSPE1", "HSPH1", "HTATSF1", "HTRA2", "HUS1", "HUWE1", "HYOU1", "IARS", "IARS2", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDI1", "IFT27", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IK", "IKBIP", "IKBKG", "ILF2", "ILF3", "ILK", "ILKAP", "ILVBL", "IMMT", "IMP3", "IMP4", "IMPA1", "IMPAD1", "IMPDH1", "IMPDH2", "INA", "INCENP", "INTS11", "INTS14", "INTS3", "INTS7", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IQGAP2", "IRGQ", "IRS4", "ISOC1", "IST1", "ITCH", "ITGB1", "ITM2C", "ITPA", "IVD", "JAGN1", "JPT2", "JUP", "KARS", "KAT7", "KCTD12", "KCTD5", "KDELC2", "KDELR1", "KDM1A", "KDM1B", "KDM2A", "KDM3B", "KDSR", "KHDRBS1", "KHSRP", "KIAA0319L", "KIAA0368", "KIAA0391", "KIAA1147", "KIAA1468", "KIAA2013", "KIF11", "KIF14", "KIF15", "KIF18B", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF4A", "KIF5B", "KIFBP", "KIFC1", "KIN", "KLC1", "KLC2", "KLC4", "KMT2A", "KNTC1", "KPNA1", "KPNA2", "KPNA3", "KPNA6", "KPNB1", "KRI1", "KRR1", "KTN1", "L1RE1", "L2HGDH", "LAMP1", "LAMP2", "LAMTOR1", "LANCL2", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LAS1L", "LASP1", "LBR", "LDAH", "LDHA", "LDHB", "LEMD2", "LEMD3", "LETM1", "LGALS3BP", "LGMN", "LIG1", "LIG3", "LIMA1", "LIPA", "LMAN2", "LMF2", "LMNA", "LMNB1", "LMNB2", "LNPEP", "LNPK", "LONP1", "LPCAT1", "LPCAT3", "LPGAT1", "LRBA", "LRP1", "LRPAP1", "LRPPRC", "LRRC1", "LRRC40", "LRRC47", "LRRC59", "LRWD1", "LSM12", "LSM2", "LSM3", "LSM4", "LSM6", "LSM7", "LSS", "LTA4H", "LTV1", "LUC7L", "LUC7L2", "LYAR", "LYPLA1", "LYRM2", "LYSMD3", "LZIC", "LZTFL1", "M6PR", "MACF1", "MAD2L1", "MAGED2", "MAGT1", "MAIP1", "MAK16", "MAN1A1", "MAN2A1", "MAN2B1", "MANF", "MAP1B", "MAP1S", "MAP2K2", "MAP4", "MAPK1", "MAPK14", "MAPRE1", "MAPRE2", "MARC1", "MARCH5", "MARS", "MASTL", "MAT2A", "MAT2B", "MATR3", "MAU2", "MAVS", "MBD3", "MBOAT7", "MCAT", "MCCC1", "MCCC2", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCMBP", "MCTS1", "MCU", "MCUR1", "MDC1", "MDH1", "MDH2", "MDN1", "ME1", "ME2", "MECP2", "MED21", "MED23", "MED24", "MED25", "MEPCE", "METAP2", "METTL13", "METTL14", "METTL3", "METTL7A", "METTL7B", "METTL9", "MFN1", "MFN2", "MFSD3", "MFSD5", "MGEA5", "MGME1", "MGST2", "MGST3", "MIA2", "MIA3", "MICU1", "MICU2", "MIF", "MINDY3", "MIPEP", "MKI67", "MKRN2", "MLEC", "MMAB", "MMS19", "MOB4", "MOGS", "MORF4L1", "MOSPD2", "MOV10", "MPC2", "MPDU1", "MPG", "MPHOSPH10", "MPI", "MPP1", "MPP6", "MPRIP", "MPST", "MPV17", "MPV17L2", "MRC2", "MRE11", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL14", "MRPL15", "MRPL17", "MRPL19", "MRPL21", "MRPL22", "MRPL23", "MRPL24", "MRPL28", "MRPL3", "MRPL37", "MRPL38", "MRPL39", "MRPL40", "MRPL44", "MRPL45", "MRPL46", "MRPL50", "MRPL53", "MRPL55", "MRPL58", "MRPL9", "MRPS11", "MRPS15", "MRPS16", "MRPS18A", "MRPS22", "MRPS23", "MRPS25", "MRPS27", "MRPS30", "MRPS31", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRPS9", "MRRF", "MRTO4", "MSH2", "MSH3", "MSH6", "MSI2", "MSMO1", "MSN", "MSTO1", "MTA1", "MTA2", "MTAP", "MTBP", "MTCH1", "MTCH2", "MTDH", "MTFP1", "MTHFD1", "MTHFD1L", "MTHFD2", "MTMR14", "MTMR2", "MTOR", "MTPAP", "MTPN", "MTR", "MTX1", "MTX2", "MUT", "MVK", "MYBBP1A", "MYCBP", "MYDGF", "MYEF2", "MYG1", "MYH10", "MYH9", "MYL6", "MYO1B", "MYO1C", "MYO1D", "MYO6", "NAA15", "NAA25", "NAA35", "NAA40", "NAA50", "NADK2", "NAE1", "NAF1", "NAGA", "NAGLU", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NAPG", "NARS", "NASP", "NAT10", "NAXE", "NCAPD2", "NCAPD3", "NCAPG", "NCAPG2", "NCAPH", "NCBP1", "NCBP3", "NCDN", "NCKAP1", "NCL", "NCLN", "NCSTN", "ND1", "NDC1", "NDUFA11", "NDUFA13", "NDUFA4", "NDUFA5", "NDUFA7", "NDUFA8", "NDUFA9", "NDUFAF2", "NDUFAF3", "NDUFAF4", "NDUFAF7", "NDUFB1", "NDUFB10", "NDUFB3", "NDUFB4", "NDUFB5", "NDUFB6", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS6", "NDUFS7", "NDUFS8", "NDUFV1", "NDUFV2", "NECAP2", "NEFL", "NEFM", "NEK9", "NELFCD", "NELFE", "NEMF", "NENF", "NES", "NFATC2IP", "NFU1", "NGDN", "NHP2", "NIFK", "NIP7", "NIPSNAP1", "NIPSNAP2", "NKRF", "NKTR", "NLE1", "NLN", "NLRX1", "NME1", "NMT1", "NNT", "NOA1", "NOB1", "NOC2L", "NOC3L", "NOC4L", "NOL10", "NOL11", "NOL6", "NOL7", "NOL8", "NOL9", "NOLC1", "NOM1", "NONO", "NOP14", "NOP16", "NOP2", "NOP53", "NOP56", "NOP58", "NOP9", "NOSIP", "NPC1", "NPC2", "NPEPPS", "NPLOC4", "NPM1", "NRDC", "NSA2", "NSD2", "NSDHL", "NSF", "NSMCE2", "NSUN2", "NSUN5", "NT5C2", "NT5C3B", "NT5DC1", "NT5DC2", "NTHL1", "NTMT1", "NTPCR", "NUB1", "NUBP2", "NUBPL", "NUCB1", "NUCB2", "NUCKS1", "NUDC", "NUDCD1", "NUDCD2", "NUDT1", "NUDT16L1", "NUDT21", "NUDT5", "NUDT9", "NUF2", "NUFIP2", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP160", "NUP188", "NUP205", "NUP210", "NUP214", "NUP35", "NUP37", "NUP43", "NUP50", "NUP54", "NUP58", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NUTF2", "NVL", "NXF1", "NXN", "OAT", "OCIAD1", "OCLN", "OCRL", "OGDH", "OGT", "OLA1", "OPA1", "OPA3", "OSBP", "OSBPL3", "OSBPL6", "OSBPL8", "OSBPL9", "OSGEP", "OTUB1", "OTUD4", "OTUD7B", "OXA1L", "OXCT1", "OXSR1", "P3H1", "P3H4", "P4HA1", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PAF1", "PAFAH1B1", "PAFAH1B2", "PAFAH1B3", "PAICS", "PAIP1", "PAIP2", "PAK1IP1", "PAK2", "PALLD", "PANK4", "PAPOLA", "PARG", "PARK7", "PARN", "PARP1", "PATL1", "PAWR", "PBDC1", "PBK", "PBRM1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCID2", "PCK2", "PCLAF", "PCM1", "PCMT1", "PCNA", "PCNP", "PCYOX1", "PDAP1", "PDCD11", "PDCD5", "PDCD6", "PDCD6IP", "PDCL3", "PDE12", "PDE6D", "PDHA1", "PDHB", "PDIA3", "PDIA4", "PDIA5", "PDIA6", "PDK3", "PDLIM1", "PDLIM5", "PDLIM7", "PDPR", "PDS5A", "PDS5B", "PDXDC1", "PDXK", "PEBP1", "PECR", "PEF1", "PELO", "PELP1", "PEPD", "PES1", "PEX11A", "PEX14", "PEX16", "PEX19", "PEX5", "PFAS", "PFDN2", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGM3", "PGP", "PGRMC1", "PGRMC2", "PHAX", "PHB", "PHB2", "PHC2", "PHF5A", "PHF6", "PHGDH", "PHIP", "PHKA1", "PI4K2A", "PI4KB", "PIBF1", "PICALM", "PIGK", "PIGS", "PIGT", "PIGU", "PIK3R4", "PIN4", "PINX1", "PIP4K2C", "PIR", "PISD", "PITHD1", "PITPNB", "PITRM1", "PKM", "PKMYT1", "PKN1", "PKN2", "PLA2G15", "PLAA", "PLBD2", "PLCG1", "PLD3", "PLD6", "PLEC", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLPBP", "PLRG1", "PLS3", "PM20D2", "PMF1", "PMPCA", "PMPCB", "PMVK", "PNKP", "PNN", "PNO1", "PNP", "PNPLA6", "PNPT1", "PODXL", "POFUT1", "POGZ", "POLA1", "POLA2", "POLD1", "POLD2", "POLD3", "POLDIP2", "POLDIP3", "POLE", "POLE3", "POLE4", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2A", "POLR2B", "POLR2C", "POLR2D", "POLR2E", "POLR2F", "POLR2G", "POLR2L", "POLR3A", "POLR3C", "POLRMT", "PON2", "POP1", "POR", "PPA1", "PPA2", "PPAN", "PPAT", "PPIB", "PPIC", "PPID", "PPIF", "PPIH", "PPIL1", "PPIL3", "PPIL4", "PPM1G", "PPME1", "PPOX", "PPP1CA", "PPP1CB", "PPP1R10", "PPP1R12A", "PPP1R8", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP2R5E", "PPP3CA", "PPP4C", "PPP4R1", "PPP4R3A", "PPP5C", "PPP6C", "PPP6R3", "PPT1", "PPT2", "PPWD1", "PRAF2", "PRC1", "PRCC", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PREP", "PREPL", "PRIM1", "PRIM2", "PRKAA2", "PRKACA", "PRKAG1", "PRKAR1A", "PRKAR2A", "PRKCB", "PRKCSH", "PRKDC", "PRKRA", "PRMT1", "PRMT3", "PRMT5", "PRMT9", "PRPF19", "PRPF31", "PRPF38B", "PRPF39", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPSAP1", "PRPSAP2", "PRRC1", "PRRC2A", "PRRC2C", "PRTFDC1", "PSAP", "PSAT1", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD6", "PSMD7", "PSMD8", "PSMD9", "PSME1", "PSME2", "PSME3", "PSME4", "PSMG1", "PSPC1", "PTBP1", "PTCD3", "PTDSS1", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK7", "PTPA", "PTPMT1", "PTPN1", "PTPN11", "PTPRF", "PTRH2", "PUDP", "PUF60", "PUM1", "PUM3", "PURA", "PUS7", "PWP1", "PWP2", "PXMP2", "PXN", "PYCR1", "PYCR2", "PYCR3", "PYGB", "PYGL", "Q6ZSR9", "QARS", "QKI", "QRSL1", "QSOX2", "QTRT2", "RAB10", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB1B", "RAB21", "RAB24", "RAB31", "RAB39A", "RAB3GAP1", "RAB3GAP2", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RAB8A", "RAB9A", "RABAC1", "RABEP1", "RABEPK", "RABGAP1", "RABL6", "RAC1", "RACGAP1", "RACK1", "RAD21", "RAD23A", "RAD23B", "RAD50", "RAE1", "RAI14", "RALA", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP6", "RANBP9", "RANGAP1", "RAP2B", "RAPGEF2", "RARS", "RARS2", "RAVER1", "RBBP5", "RBBP6", "RBBP7", "RBM10", "RBM12", "RBM14", "RBM17", "RBM19", "RBM22", "RBM25", "RBM26", "RBM27", "RBM28", "RBM34", "RBM39", "RBM4", "RBM5", "RBM6", "RBM8A", "RBMX", "RBP1", "RCC1", "RCC2", "RCL1", "RCN1", "RCN2", "RDH11", "RDH13", "RDH14", "RDX", "RECQL", "REEP4", "REEP5", "RER1", "RETREG3", "RETSAT", "REXO4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RFT1", "RHBDD2", "RHEB", "RHOG", "RHOT1", "RHOT2", "RIDA", "RIF1", "RINT1", "RMC1", "RMDN1", "RMDN3", "RMND1", "RNASEH2A", "RNASET2", "RNF139", "RNF14", "RNF20", "RNF219", "RNF40", "RNH1", "RNPEP", "ROCK1", "RPA1", "RPA2", "RPAP1", "RPAP3", "RPF1", "RPF2", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPN1", "RPN2", "RPP30", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS28", "RPS29", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RPTOR", "RPUSD3", "RRBP1", "RRM1", "RRM2", "RRP1", "RRP12", "RRP15", "RRP1B", "RRP36", "RRP8", "RRP9", "RRS1", "RSL1D1", "RSL24D1", "RSPRY1", "RSU1", "RTCB", "RTN2", "RTN3", "RTN4", "RTN4IP1", "RTRAF", "RUFY1", "RUVBL1", "RUVBL2", "S100A11", "S100A13", "SAAL1", "SACM1L", "SAE1", "SAFB", "SAFB2", "SAMD4B", "SAMHD1", "SAMM50", "SAP18", "SAR1A", "SARM1", "SARNP", "SARS", "SARS2", "SART1", "SART3", "SBDS", "SCAF1", "SCAF4", "SCAMP1", "SCAMP2", "SCAMP3", "SCARB1", "SCARB2", "SCCPDH", "SCD", "SCFD1", "SCML2", "SCO1", "SCO2", "SCP2", "SCPEP1", "SCRIB", "SCRN1", "SDAD1", "SDCBP", "SDF4", "SDHA", "SDHB", "SDR39U1", "SEC11A", "SEC16A", "SEC22B", "SEC23A", "SEC23B", "SEC23IP", "SEC24A", "SEC24B", "SEC24C", "SEC24D", "SEC31A", "SEC61A1", "SEC61B", "SEC61G", "SEC62", "SEC63", "SEH1L", "SEL1L", "SENP3", "SEPHS1", "SEPT11", "SEPT2", "SEPT6", "SEPT7", "SEPT9", "SERBP1", "SERPINB6", "SERPINH1", "SET", "SEZ6L2", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFXN1", "SFXN2", "SFXN4", "SGPL1", "SGTA", "SH3GL1", "SH3GLB1", "SH3GLB2", "SHMT1", "SHMT2", "SIGMAR1", "SIN3A", "SIRT1", "SKIV2L", "SKIV2L2", "SKP1", "SKP2", "SLC12A9", "SLC16A1", "SLC19A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A17", "SLC25A19", "SLC25A20", "SLC25A21", "SLC25A22", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A33", "SLC25A4", "SLC25A40", "SLC25A42", "SLC25A5", "SLC25A6", "SLC27A4", "SLC30A5", "SLC30A6", "SLC33A1", "SLC35A4", "SLC35B2", "SLC35F2", "SLC39A14", "SLC3A2", "SLC4A1AP", "SLC4A7", "SLC6A15", "SLC9A3R1", "SLFN11", "SLIRP", "SLIT2", "SLK", "SLTM", "SMAP1", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC6", "SMG5", "SMN1*", "SMNDC1", "SMPD4", "SMS", "SMU1", "SMYD3", "SNAP23", "SND1", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPC", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNW1", "SNX1", "SNX12", "SNX17", "SNX19", "SNX2", "SNX27", "SNX3", "SNX4", "SNX5", "SNX6", "SNX9", "SOAT1", "SOD2", "SON", "SORD", "SPAG9", "SPART", "SPATA5", "SPATA5L1", "SPC24", "SPC25", "SPCS2", "SPECC1L", "SPEN", "SPHK2", "SPNS1", "SPR", "SPTAN1", "SPTBN1", "SPTBN2", "SPTLC1", "SPTLC2", "SQLE", "SQSTM1", "SRCAP", "SREK1", "SRI", "SRM", "SRP14", "SRP54", "SRP68", "SRP72", "SRP9", "SRPK1", "SRPK2", "SRPRA", "SRPRB", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF3", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSNA1", "SSR1", "SSR4", "SSRP1", "STAG1", "STAG2", "STAM", "STAMBP", "STARD3", "STARD3NL", "STARD7", "STAT1", "STAT3", "STAU1", "STAU2", "STIM1", "STIP1", "STK26", "STK4", "STMN1", "STOM", "STOML2", "STRAP", "STRBP", "STRN", "STT3A", "STT3B", "STX10", "STX12", "STX18", "STX3", "STX4", "STX5", "STX7", "STX8", "STXBP3", "STXBP4", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGP2", "SUGT1", "SUN1", "SUN2", "SUPT16H", "SUPT5H", "SUPT6H", "SUPV3L1", "SURF4", "SURF6", "SUZ12", "SV2A", "SYAP1", "SYMPK", "SYNCRIP", "SYNE2", "SYNGR2", "SYNJ2BP", "SYS1", "TAB1", "TACC3", "TADA3", "TAF15", "TAF6L", "TAGLN2", "TALDO1", "TAOK1", "TAP1", "TARDBP", "TARS", "TARS2", "TBC1D13", "TBC1D15", "TBC1D2B", "TBC1D4", "TBC1D9B", "TBCA", "TBCB", "TBCD", "TBCE", "TBL2", "TBL3", "TBRG4", "TCAF1", "TCEA1", "TCERG1", "TCOF1", "TCP1", "TDRKH", "TECR", "TELO2", "TERF2IP", "TES", "TEX10", "TEX264", "TFAM", "TFB1M", "TFCP2", "TFG", "TFIP11", "TFRC", "TGOLN2", "THOC1", "THOC2", "THOC3", "THOC5", "THOC6", "THOP1", "THRAP3", "THUMPD1", "THUMPD3", "THYN1", "TIA1", "TIAL1", "TIGAR", "TIMELESS", "TIMM10", "TIMM10B", "TIMM13", "TIMM17A", "TIMM17B", "TIMM23", "TIMM44", "TIMM50", "TIMM8B", "TIMM9", "TIPRL", "TJP1", "TK1", "TKT", "TLCD1", "TLN1", "TM9SF2", "TM9SF3", "TM9SF4", "TMA16", "TMCO1", "TMED10", "TMED2", "TMED4", "TMED5", "TMED7", "TMED9", "TMEM109", "TMEM126A", "TMEM126B", "TMEM14C", "TMEM160", "TMEM165", "TMEM167A", "TMEM192", "TMEM199", "TMEM201", "TMEM205", "TMEM209", "TMEM214", "TMEM230", "TMEM259", "TMEM30A", "TMEM33", "TMEM38B", "TMEM43", "TMEM59", "TMEM65", "TMEM87A", "TMEM97", "TMF1", "TMOD1", "TMOD3", "TMPO", "TMPO", "TMPPE", "TMTC3", "TMX1", "TMX2", "TMX3", "TMX4", "TNKS1BP1", "TNPO1", "TNPO2", "TNPO3", "TOE1", "TOMM20", "TOMM22", "TOMM34", "TOMM40", "TOMM5", "TOMM70", "TOP1", "TOP2A", "TOP2B", "TOR1AIP1", "TOR1B", "TOR3A", "TOX4", "TP53", "TP53I11", "TPD52", "TPD52L2", "TPI1", "TPM1", "TPM3", "TPM4", "TPP1", "TPP2", "TPR", "TPT1", "TPX2", "TRA2A", "TRA2B", "TRABD", "TRAF2", "TRAM1", "TRAP1", "TRAPPC5", "TRIM21", "TRIM25", "TRIM28", "TRIM33", "TRIP12", "TRIP13", "TRIR", "TRMT10C", "TRMT11", "TRMT1L", "TRMT2A", "TRMU", "TROVE2", "TRRAP", "TRUB1", "TSFM", "TSG101", "TSN", "TSNAX", "TSPAN10", "TSPAN3", "TSPAN6", "TSPO", "TSR1", "TST", "TTC1", "TTC19", "TTC26", "TTC37", "TTC38", "TTC4", "TTK", "TTLL12", "TTYH3", "TUBB", "TUBB2A", "TUBB2B", "TUBB3", "TUBB4B", "TUBB6", "TUBGCP2", "TUBGCP3", "TUBGCP4", "TUFM", "TWF1", "TWF2", "TWISTNB", "TWNK", "TXLNA", "TXLNG", "TXNDC12", "TXNDC17", "TXNDC5", "TXNDC9", "TXNL1", "TXNRD1", "TYMS", "U2AF1", "U2AF2", "U2SURP", "UAP1", "UBA1", "UBA2", "UBA3", "UBA6", "UBAC1", "UBAP2L", "UBE2J1", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2O", "UBE2S", "UBE3A", "UBE4A", "UBE4B", "UBLCP1", "UBP1", "UBQLN2", "UBQLN4", "UBR4", "UBR5", "UBTF", "UBXN1", "UBXN4", "UBXN7", "UCHL5", "UCK2", "UFC1", "UFD1", "UFL1", "UFM1", "UGCG", "UGGT1", "UGP2", "UGT8", "UHRF1", "ULK3", "UMPS", "UNC119", "UNC119B", "UNC45A", "UNG", "UPF1", "UQCC2", "UQCR10", "UQCRB", "UQCRC1", "UQCRC2", 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"YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2", "ZC3H11A", "ZC3H14", "ZC3H15", "ZC3H18", "ZC3HAV1", "ZC3HC1", "ZCCHC3", "ZCRB1", "ZDHHC13", "ZFR", "ZFYVE16", "ZMPSTE24", "ZMYM2", "ZNF207", "ZNF280C", "ZNF281", "ZNF318", "ZNF326", "ZNF512", "ZNF512B", "ZNF622", "ZNF638", "ZPR1", "ZRANB2", "ZW10", "ZWINT", "ZYX"], "leading_proteins": ["ARL10", "ARL6IP6", "ATP13A1", "ATP1A1", "ATP5L", "ATPAF1", "BSDC1", "C12orf73", "C16orf58", "COMT", "COX7A2", "CTDSPL2", "CYB5D2", "CYP20A1", "DCAF16", "DCAKD", "DCTN3", "DHRS1", "DOLPP1", "EFCAB14", "EMC2", "EMC4", "EMC7", "ENDOD1", "FAM114A2", "FAM177A1", "FAM210A", "FAM49B", "FKBP1A", "FKBP9", "FUNDC2", "GAA", "GGCX", "GLA", "GOLT1B", "GPR107", "GPR89B", "HINT3", "HSDL1", "HSDL2", "IKBIP", "IMPAD1", "IRGQ", "ISOC1", "KIAA1147", "KIAA2013", "LAS1L", "LMF2", "LSM6", "LYRM2", "LYSMD3", "MAIP1", "MAU2", "METTL9", "MFSD3", "MRPL45", "MRPL50", "MRPS18A", "MRPS9", "ND1", "NDUFA11", "NDUFA13", "NDUFB1", "NDUFB10", "NDUFB3", "NDUFB4", "NDUFB6", 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file mode 100644 index 0000000000000000000000000000000000000000..b2c63e6dd703a763292af998bc9daa447bd50dd0 --- /dev/null +++ b/protein_atlas_biological_process/basic/plot_9.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:26f00bd1ff5570367d99dd66092a3d1e6834839356523f8841d294b77a8ff7d6 +size 129974 diff --git a/protein_atlas_biological_process/consensus.joblib b/protein_atlas_biological_process/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..af1c73b7b2699275d14f5f07996672828bc52e2c --- /dev/null +++ b/protein_atlas_biological_process/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:546d683c195b6044d85ea27af46a0da7b613a28edbf3ae428c8c67e09f9394c0 +size 84053 diff --git a/protein_atlas_biological_process/df_merge.tsv b/protein_atlas_biological_process/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..46d44e1579023000bf9771403ad9e1957e53357e --- /dev/null +++ b/protein_atlas_biological_process/df_merge.tsv @@ -0,0 +1,18 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Ion transport 30 56 4.337758533448285 1.4394316874666302e-05 19.82766990291262 54.68446601941748 1.177785596906995 0.303722365376275 8.99659651977233 7.41832233515522 1.8666057057567336 0.3607289685223158 2.3282781034494917e-06 0.0002940200950487 0.0023186425208291 0.0006522405746686 3.937408812458855e-06 +Translocation 25 51 3.511009855686943 0.0004464078476038 12.434466019417476 47.86165048543689 1.1297087783550883 0.3515144245437065 6.687771513864753 3.601211391947168 1.550426642680832 0.3811939235350816 0.0001268753792658 0.0053226708337122 0.0006737903450178 0.0003500899567747 0.00016726606185 +Electron transport 18 45 3.5056648252488665 0.0004554683917596 14.983009708737864 45.592233009708735 1.1180311721330871 0.3315827540150002 5.69510117113123 4.184313965655804 1.5984402393879058 0.3574888993156041 6.775418672319555e-08 0.0112094197529472 0.0022705729972834 1.7654248487926034e-05 1.0775434398012725e-07 +Respiratory chain 17 32 3.19568244941418 0.0013950055268292 10.895631067961164 31.91990291262136 1.1075564231308468 0.3095707256998049 4.44287149555612 3.6670789399383112 1.4970961025113558 0.3356221172021658 4.813458818255608e-07 0.0345877004093447 0.0026534702472046 8.915246903848725e-05 6.865405772962376e-07 +Sphingolipid metabolism 8 11 3.0869490922094687 0.0020222222561552 5.075242718446602 9.720873786407768 1.0723891387155546 0.1672146303539832 2.245095774833478 1.0461446620678432 1.744521381224598 0.248179764200939 5.228213382796175e-08 0.0036723611473879 2.674004210290638e-05 1.53739672039809e-07 6.740904130024404e-08 +Hydrogen ion transport 7 20 2.5828157971614907 0.0097997629699553 6.152912621359223 19.560679611650485 0.8019462838912398 0.3170771992837126 2.890966221074556 1.405159537040464 1.2709247974732976 0.29451915785821 0.0025303492764951 0.0096266028600564 0.0030930435255612 0.0058861279901433 0.0029323640599066 +ER-Golgi transport 19 46 2.5328401160818315 0.0113142546588749 13.189320388349516 50.09466019417476 1.0113245710455496 0.4417664900586612 5.844513029144237 4.526971021787617 1.2802141654412966 0.393016134031976 0.0003054276242915 0.0068431745235502 0.0073240711492788 0.0431820162236638 0.0003990959978531 +Antiport 6 7 2.3680156290715475 0.0178837804110303 3.2063106796116503 7.097087378640777 0.8539962634551548 0.3166005193161004 2.0440914093762896 1.1428508308135348 1.2051823486844502 0.2998011899649158 0.0017589920567973 1.0 1.0 0.0111687214620054 0.0020034595379071 +Cholesterol metabolism 9 24 2.287363248165101 0.0221746295839069 7.111650485436893 23.79854368932039 1.169709264926864 0.2871268807807383 2.8890755390042298 2.7173834172675666 1.205315163774447 0.3061468445376054 2.875022417974631e-05 0.0196403757049561 0.0088720794008613 8.176671580407137e-05 3.698647282213466e-05 +Vision 5 7 2.264582044062361 0.0235383398273709 2.3470873786407767 5.992718446601942 1.08525596348634 0.2199144433248849 1.3876767838522928 1.281854462283163 1.178949427510656 0.2385050933787637 0.0007690982877224 0.1135912525516411 0.0016492758756177 0.0026445688691081 0.0008975978654728 +Sensory transduction 5 7 2.264582044062361 0.0235383398273709 2.3907766990291264 6.065533980582524 1.0901502088613606 0.2182341455376904 1.4245463862041683 1.4083924790550797 1.1790733646497054 0.2382326050755758 0.0021215648485544 0.134742527043449 0.0028129637769054 0.0052222662915419 0.0024615078608799 +Sterol metabolism 9 25 2.2495315767007105 0.024478696169105 7.606796116504855 25.203883495145632 1.1785484151208083 0.2872927387372206 3.1377365577760563 3.096691699470945 1.2399567569518877 0.3064799172119154 5.206826791484075e-05 0.0221752921752284 0.0105950719619242 0.0001248764648091 6.673062892762862e-05 +Amino-acid transport 4 6 2.1082712191996302 0.0350075359701618 3.063106796116505 7.016990291262136 0.9299828460487652 0.271909550896337 1.9171930478617292 1.3907470472448622 1.1684874391815692 0.271335812648974 0.7452652672533333 1.0 1.0 1.0 0.7557009949380857 +Steroid metabolism 9 26 2.104388854689647 0.0353445408296808 7.703883495145631 26.439320388349515 1.128083592407629 0.3052190273048834 3.279782799169419 3.1412859163137186 1.216134343451914 0.3162944576553002 0.0001744125605688 0.0285808600856777 0.0153233347656195 0.0002989066385229 0.0002215646203362 +Lipid biosynthesis 28 57 2.090854675077715 0.0365410931693173 15.9126213592233 54.70145631067961 0.536392080403718 0.3712014565741516 7.84820404428356 6.53895703030749 1.480689631873909 0.3519149032884112 2.460340709012243e-10 0.4490556485893446 0.1121744330509924 6.662696902740941e-06 8.121902843675621e-11 +Calcium transport 5 8 2.045353536552098 0.0408200161753977 3.7305825242718447 8.240291262135923 0.5020754788348019 0.3462849026834517 2.2148520410126937 1.861210565609195 1.3394131933179945 0.3209721672484884 0.2411880832418149 1.0 1.0 0.2188913793199876 0.2549386973290503 +Symport 5 6 2.0265122767694024 0.0427123159462512 2.844660194174758 6.961165048543689 0.6469017708869542 0.3932450371351912 1.8940749800794765 1.272733699501336 1.0491712043829624 0.3136298512602674 0.204439302357496 1.0 1.0 0.5587108083967203 0.2166592364389877 diff --git a/protein_atlas_biological_process/metrics.json b/protein_atlas_biological_process/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..2bf68b585b2fc6a6a6bb78794ae52cd06003e0d0 --- /dev/null +++ b/protein_atlas_biological_process/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2974, + "annotations_size": 164, + "title": "Average number of proteins per term", + "value": 29.585365853658537 +} \ No newline at end of file diff --git a/protein_atlas_biological_process/paths.json b/protein_atlas_biological_process/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..ff22c6f323042ff72c7d3b367151c138b6724bed --- /dev/null +++ b/protein_atlas_biological_process/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/protein_atlas_biological_process/fragment/C220/C220_val_log2fc"} \ No newline at end of file diff --git a/protein_atlas_biological_process/result.tsv b/protein_atlas_biological_process/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..ee1522041892d453da776093eaca85b3e848eb00 --- /dev/null +++ b/protein_atlas_biological_process/result.tsv @@ -0,0 +1,48 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Ion transport 0.638706224796643 4.337758533448285 1.4394316874666302e-05 0.002357900732299 0.0023606679674454 56 Q9BVC6,Q9C0H2,P35670,Q9Y277,P05023,P45880,O96008,O75964,P51790,Q9H2J7,Q13586,P20020,P21796,P00846,Q6NXT4,Q8TAD4,Q6P4Q7,P24539,Q9Y487,P16615,P51798,Q96AQ8,Q93050,Q8NE01,Q4KMQ2,O95202,Q15043,P56385,Q15904,Q96S66 30 +Translocation 0.5758853935408682 3.511009855686943 0.0004464078476038 0.070610381802672 0.02489893874953 51 Q99595,O60830,Q8N1F7,O14925,P57740,Q99567,Q9Y5J9,Q9NS69,O43615,Q9Y5L4,Q9BTX1,Q96DA6,Q92621,P41208,Q99442,Q8NFH5,Q15629,O75381,Q9UBU9,Q9NRG9,P60059,Q9Y5J7,Q3ZCQ8,Q9Y5J6,Q7Z3B4 25 +Electron transport 0.601068540481683 3.5056648252488665 0.0004554683917596 0.0719909855861242 0.02489893874953 45 O43169,O95139,O14949,Q9Y6M9,O43676,Q9P0J0,Q86Y39,Q9H3N1,O75438,O95168,P00403,Q9H1E5,P21912,P22695,O96000,Q9UDW1,P03886,Q96CU9 18 +Respiratory chain 0.6034608777118863 3.19568244941418 0.0013950055268292 0.2046242466572857 0.0571952265999993 32 O95139,O14949,Q9Y6M9,O43676,P51970,Q86Y39,Q9P0J0,O75438,P08574,Q6DKK2,P00403,O95168,P22695,O96000,Q9UDW1,P03886,Q96CU9 17 +Sphingolipid metabolism 0.8356515805163283 3.0869490922094687 0.0020222222561552 0.2824984938335629 0.0663288900018914 11 O15269,P04062,O95470,P07602,P17900,Q9NZ01,Q13510,Q16739 8 +Hydrogen ion transport 0.588319660532168 2.5828157971614907 0.0097997629699553 0.8011268023994876 0.0927768882027743 20 Q93050,P24539,P00846,Q9Y487,P56385,Q15904,O75964 7 +ER-Golgi transport 0.4920061073718071 2.5328401160818315 0.0113142546588749 0.8452763463124995 0.0927768882027743 46 Q15363,Q9NR31,O95070,O95197,Q9Y282,Q15437,P24390,P18085,Q15436,Q12981,Q969M3,P51572,P49755,Q9P2W9,O15498,O95249,Q9HCU5,Q96RQ1,O75396 19 +Antiport 0.8190091001011042 2.3680156290715475 0.0178837804110303 0.9481542829251536 0.1333154539731352 7 O95202,P12236,P41440,P51798,P12235,P05141 6 +Cholesterol metabolism 0.5320913095408525 2.287363248165101 0.0221746295839069 0.97471555692451 0.1424081948668384 24 P35610,O15118,P37268,P04062,Q15800,Q14739,Q16850,Q15392,O75477 9 +Vision 0.7966890390517984 2.264582044062361 0.0235383398273709 0.97988814580645 0.1424081948668384 7 O60313,O43924,Q13432,P50897,Q9H6K4 5 +Sensory transduction 0.7966890390517984 2.264582044062361 0.0235383398273709 0.97988814580645 0.1424081948668384 7 O60313,O43924,Q13432,P50897,Q9H6K4 5 +Sterol metabolism 0.5228945295276736 2.2495315767007105 0.024478696169105 0.9828277052623944 0.1424081948668384 25 P35610,O15118,P37268,P04062,Q15800,Q14739,Q16850,Q15392,O75477 9 +Amino-acid transport 0.7769586047782551 2.1082712191996302 0.0350075359701618 0.9971031688981298 0.1756516574565957 6 Q9H2J7,Q6P4A7,Q96NB2,Q15758 4 +Steroid metabolism 0.5005908083804639 2.104388854689647 0.0353445408296808 0.997264447022936 0.1756516574565957 26 P35610,O15118,P37268,P04062,Q15800,Q14739,Q16850,Q15392,O75477 9 +Lipid biosynthesis 0.4143026624577551 2.090854675077715 0.0365410931693173 0.997768257204558 0.1762570376402364 57 Q9NUQ2,Q96G23,Q15800,Q92604,Q53GQ0,Q9H7Z7,O95864,Q9NZ01,Q8WUK0,Q9UBM7,Q16850,Q14739,O00116,Q9UG56,Q15392,O00767,Q8NBQ5,P37268,P49327,Q9BY49,Q16739,P27544,Q8NF37,Q6Y1H2,O15121,O95674,Q9P035,Q96N66 28 +Calcium transport 0.7369156868757755 2.045353536552098 0.0408200161753977 0.9989244822029146 0.1912709329361495 8 Q13586,P20020,O95202,P16615,Q96AQ8 5 +Symport 0.7594339622641433 2.0265122767694024 0.0427123159462512 0.9992220255498372 0.194578328199589 6 Q9H2J7,P53985,Q00325,Q9H936,Q15758 5 +Steroid biosynthesis 0.4968175065895842 1.922381093696603 0.0545578227637109 0.9998990432100529 0.2418238630607726 21 Q8NBQ5,P37268,Q15800,Q53GQ0,Q14739,Q16850,Q15392 7 +Neurotransmitter transport 0.8473969551822358 1.903083121552502 0.0570296999625394 0.999934283511234 0.2461281787856967 4 Q9H2J7,Q7L0J3 2 +Phospholipid metabolism 0.5513216753886957 1.8856592776066023 0.0593408838087856 0.9999560567604748 0.2495360242215602 16 Q9NUQ2,Q8NF37,Q92604,O14735,O95674,Q9UG56,Q8WUK0,Q96N66 8 +Phospholipid biosynthesis 0.556638583287319 1.8370646357213312 0.066200354065546 0.999986768544891 0.2690167108262039 15 Q9NUQ2,Q8NF37,Q92604,O14735,O95674,Q9UG56,Q8WUK0,Q96N66 8 +Adaptive immunity 0.5728364261072431 1.783522753371534 0.0745012474930151 0.9999969405921098 0.2776864679285108 13 Q9NZ08,P01889,P04083,P10321,P04439,Q03518 6 +Apoptosis 0.3943751320359664 1.6616077600753305 0.0965914464024426 0.999999941788538 0.3126480320375036 113 Q96A26,O95470,O95197,Q03164,Q9H3K2,P46379,Q9Y371,Q9UHX1,Q5J8M3,P21796,Q16539,Q9NZJ7,O95831,Q12981,O14737,Q96FV9,Q9P0J0,P12236,Q96KA5,Q15041,O60313,P09601,Q13043,Q6NUQ4,Q9NR28,Q9UDX5 26 +Zinc transport 0.921575227196225 1.587283347231677 0.1124484851090852 0.9999999968103324 0.3126480320375036 3 Q8TAD4,Q6NXT4 2 +Cholesterol biosynthesis 0.518860763022456 1.5850834041751194 0.1129473856993561 0.999999997091304 0.3126480320375036 15 Q14739,Q16850,Q15800,Q15392 4 +Sterol biosynthesis 0.507194493376922 1.58275976798279 0.1134762298373845 0.999999997362314 0.3126480320375036 16 Q14739,Q16850,Q15800,Q15392 4 +Sodium transport 0.7065911818400233 1.5586838705174115 0.1190712212053433 0.9999999990661204 0.3126480320375036 5 Q9H2J7,P05023,Q9Y6M7 3 +ATP synthesis 0.6367362250078914 1.542772490895176 0.1228859862406492 0.9999999995416552 0.3126480320375036 8 O75964 1 +GPI-anchor biosynthesis 0.6999536434921376 1.5277764892611043 0.1265680415003118 0.999999999770084 0.3126480320375036 5 Q9H490,O43292 2 +Lipid metabolism 0.3881218982279174 1.4728055297544662 0.1408034808597911 0.99999999998447 0.3372006761485105 124 O15269,Q9NUQ2,P35610,Q96G23,O95470,Q15800,Q92604,Q8NCC3,Q53GQ0,Q9H7Z7,Q8N2K0,O95864,O14735,Q9NZ01,Q8WUK0,Q99735,P04062,P07602,P17900,Q8NHP8,Q14739,Q16850,Q9UBM7,O00116,Q9UG56,Q15392,O00767,P37268,P23786,Q8N2A8,Q8NBQ5,O15254,P40939,P49327,Q9BY49,Q9H6V9,Q13510,P51648,Q16739,P27544,O15118,Q8NF37,Q6Y1H2,O15121,Q15067,Q06136,A1L0T0,O95674,Q9P035,Q8IY17,O75477,Q96N66 52 +Unfolded protein response 0.5670154364315441 1.3078828392684465 0.1909130509468235 0.9999999999999992 0.4190938537166592 9 Q9GZP9,Q15629 2 +Transport 0.4834850699724581 1.3056877233298043 0.1916587745655453 0.9999999999999992 0.4190938537166592 493 O43169,Q99595,Q9BVC6,O60830,Q96P70,Q9Y5X3,O95197,Q9C0H2,P41440,Q53FT3,Q70HW3,Q8IXU6,Q9UBX3,P45880,Q9Y282,Q9UDW1,O75964,Q9P253,Q8N4H5,Q9NS69,P51790,P24390,P21796,Q13586,P00846,P20020,Q9Y5L4,O43676,Q6NXT4,Q96DA6,Q9NV96,Q9H2D1,Q9Y3A3,Q96NB2,P51970,P41208,Q13432,Q8N5M9,Q15436,Q99442,Q15629,O60499,Q9H936,O60831,O14949,P49755,P61421,Q13505,Q9P2W9,Q9Y5J7,P60059,P78406,O00461,Q9BQE5,Q92945,Q9Y3E0,Q8N2H4,Q6DKK2,O43674,Q96ES6,O15127,Q3ZCQ8,O15498,Q9Y619,O95249,P03886,O75746,Q93050,Q9BSK2,Q9HCU5,Q9UM00,O75396,P62820,Q9H0U4,Q9H1E5,P12235,Q15758,Q9H9B4,P28288,A6NIH7,Q12907,O00400,P51151,Q8N668,O14925,Q86Y39,Q14849,Q9Y277,Q03518,Q15437,Q9BTX1,Q9NZJ7,Q9HD20,Q9BUR5,O75438,Q8NFH5,Q8TAD4,Q9Y6C9,Q96CU9,Q9BQT8,Q96FV9,P24539,P53985,P23786,Q9P0J0,P12236,P49321,Q96AQ8,P21912,Q9BUN8,O15118,O95202,Q15043,Q8TB61,Q9Y5J6,Q92973,P22695,Q15363,Q9HC21,Q9UJS0,O95070,Q9H3N1,Q9H4A6,Q96AA3,P00403,P05023,O96000,P05141,Q9H2J7,O95139,O00505,Q9Y6M9,Q7L0J3,P18085,Q00325,Q12981,O75381,P33527,Q9Y487,P16615,Q13190,P61026,O75027,Q969Q5,Q9Y3B3,Q8NE01,Q4KMQ2,Q15904,Q86VD7,Q6NUK1,O95168,Q96S66,Q9NR31,P46379,O95864,P35670,Q9H0U3,Q9Y5J9,P52292,O96008,P22626,O43615,O43681,O14828,Q969M3,Q99720,P51572,Q6P4Q7,P08183,Q12846,Q99584,P51798,Q9UNK0,Q15388,Q96RQ1,P56385,O95219,P08574,Q86Y82,O43808,Q6P4A7,A0AVF1,P53007 183 +Ubiquinone biosynthesis 0.7856662180349983 1.0567408642704257 0.2906298696061797 1.0 0.5618525176381807 2 O75208 1 +Peroxisome biogenesis 0.7876135981151048 1.0540910980112006 0.2918412114004518 1.0 0.5618525176381807 3 Q9Y5Y5,P40855 2 +Complement pathway 0.7802826379542384 1.0343388294182003 0.3009777903541186 1.0 0.5673604323916719 2 Q07021 1 +Potassium transport 0.6355354872182314 0.9794495727335376 0.3273578932816936 1.0 0.602123750631696 4 P05023,P54709 2 +Lipid transport 0.3685946765822147 0.9160607622517488 0.3596350262945313 1.0 0.634195100132292 24 O15118,Q4KMQ2,Q9BQE5,Q9BUR5,Q14849,Q99720 6 +Notch signaling pathway 0.5048909402349834 0.7787923597819203 0.4361020390705237 1.0 0.6876993693035182 6 Q9UBV2,Q92542 2 +Sodium/potassium transport 0.6855726584278687 0.664323031587414 0.5064835831732615 1.0 0.737896173161811 3 P05023 1 +Biomineralization 0.672611036339176 0.6081124458206513 0.5431128982507518 1.0 0.7530286963284009 2 Q6P4Q7 1 +Glycogen biosynthesis 0.4385314920848759 0.3409043807361983 0.7331755668090738 1.0 0.8588628068334865 5 P13807,Q04446,P31751,P46976 4 +Methionine biosynthesis 0.5706945191952706 0.2911566506535284 0.7709315147322604 1.0 0.8778492788993653 3 Q9UHY7 1 +Proline biosynthesis 0.4518518518518511 0.2568883910089964 0.7972649325609149 1.0 0.8894656390475513 4 Q53H96,P54886,Q96C36 3 +Necrosis 0.4208754208754098 0.1666495788895684 0.8676457808176796 1.0 0.9549926715040232 4 P04637,O00429,Q96HS1 3 +Phagocytosis 0.492090205318072 0.1124115778356193 0.9104970757279908 1.0 0.987745608250858 3 Q96JJ3,P20339 2 +Protein transport 0.3535122788832893 0.0299471867410166 0.9761091731308392 1.0 1.0 253 Q99595,Q12907,P51151,O60830,Q96P70,Q9Y5X3,Q8N668,Q96RL7,Q15363,O95070,O14925,Q9H4A6,Q53FT3,Q9NR31,Q9Y5J9,P52292,Q9P253,Q03518,Q15437,O96008,Q8N4H5,Q9NS69,O43615,P24390,O00505,Q9Y5L4,Q96DA6,Q9BTX1,Q9HD20,P18085,P41208,Q15436,Q99442,Q13432,Q8N5M9,Q8NFH5,O14828,Q15629,O60831,O60499,O75381,P49755,Q969M3,P51572,Q13505,Q9P2W9,P60059,Q9Y5J7,Q99584,Q9Y3E0,Q8N2H4,P49321,P61026,O15127,Q3ZCQ8,O15498,O95249,Q969Q5,Q9BUN8,Q9Y3B3,Q9HCU5,Q15388,O75396,P62820,Q9H0U4,O95219,Q86Y82,A0AVF1,Q9Y5J6,Q92973,A6NIH7 71 +Inflammatory response 0.3064249008090706 0.007074394392634 0.994355497018919 1.0 1.0 9 Q8IV08,P14174 2 diff --git a/protein_atlas_biological_process/selections.json b/protein_atlas_biological_process/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..5a5413d466561e383a3215d71b402def91effa04 --- /dev/null +++ b/protein_atlas_biological_process/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["ATP synthesis", "Adaptive immunity", "Amino-acid biosynthesis", "Amino-acid transport", "Angiogenesis", "Antiport", "Antiviral defense", "Apoptosis", "Aromatic hydrocarbons catabolism", "Asparagine biosynthesis", "Autophagy", "Behavior", "Biological rhythms", "Biomineralization", "Branched-chain amino acid catabolism", "Calcium transport", "Carbohydrate metabolism", "Catecholamine metabolism", "Cell adhesion", "Cell cycle", "Cell division", "Cell shape", "Chemotaxis", "Cholesterol biosynthesis", "Cholesterol metabolism", "Chromosome partition", "Cilium biogenesis/degradation", "Coenzyme A biosynthesis", "Collagen degradation", "Complement pathway", "Copper transport", "DNA condensation", "DNA damage", "DNA excision", "DNA recombination", "DNA repair", "DNA replication", "DNA synthesis", "Detoxification", "Differentiation", "ER-Golgi transport", "Electron transport", "Endocytosis", "Exocytosis", "Fatty acid biosynthesis", "Fatty acid metabolism", "Fertilization", "Fucose metabolism", "GMP biosynthesis", "GPI-anchor biosynthesis", "Galactose metabolism", "Gastrulation", "Gluconate utilization", "Gluconeogenesis", "Glucose metabolism", "Glutathione biosynthesis", "Glycogen biosynthesis", "Glycogen metabolism", "Glycolysis", "Glyoxylate bypass", "Growth arrest", "Growth regulation", "Hearing", "Heme biosynthesis", "Host-virus interaction", "Hydrogen ion transport", "Hypusine biosynthesis", "Immunity", "Inflammatory response", "Inhibition of host STAT1 by virus", "Inhibition of host STAT2 by virus", "Inhibition of host innate immune response by virus", "Inhibition of host interferon signaling pathway by virus", "Innate immunity", "Ion transport", "Iron storage", "Isoprene biosynthesis", "Leukotriene biosynthesis", "Lipid biosynthesis", "Lipid degradation", "Lipid metabolism", "Lipid transport", "Meiosis", "Melanin biosynthesis", "Methionine biosynthesis", "Methotrexate resistance", "Mitosis", "Molybdenum cofactor biosynthesis", "Myogenesis", "Necrosis", "Neurogenesis", "Neurotransmitter degradation", "Neurotransmitter transport", "Nonsense-mediated mRNA decay", "Notch signaling pathway", "Nucleotide biosynthesis", "Nucleotide metabolism", "One-carbon metabolism", "Oogenesis", "Osteogenesis", "Pentose shunt", "Peptide transport", "Peroxisome biogenesis", "Phagocytosis", "Phenylalanine catabolism", "Phospholipid biosynthesis", "Phospholipid metabolism", "Plasminogen activation", "Polyamine biosynthesis", "Porphyrin biosynthesis", "Potassium transport", "Proline biosynthesis", "Proline metabolism", "Prostaglandin biosynthesis", "Prostaglandin metabolism", "Protein biosynthesis", "Protein transport", "Purine biosynthesis", "Purine salvage", "Pyridine nucleotide biosynthesis", "Pyrimidine biosynthesis", "RNA-mediated gene silencing", "Respiratory chain", "Ribosome biogenesis", "Sensory transduction", "Serine biosynthesis", "Sodium transport", "Sodium/potassium transport", "Spermatogenesis", "Spermidine biosynthesis", "Sphingolipid metabolism", "Steroid biosynthesis", "Steroid metabolism", "Sterol biosynthesis", "Sterol metabolism", "Stress response", "Sugar transport", "Symport", "Tetrahydrobiopterin biosynthesis", "Transcription", "Transcription regulation", "Transcription termination", "Translation regulation", "Translocation", "Transport", "Tricarboxylic acid cycle", "Tyrosine catabolism", "Ubiquinone biosynthesis", "Ubl conjugation pathway", "Unfolded protein response", "Viral RNA replication", "Viral immunoevasion", "Viral penetration into host nucleus", "Virus entry into host cell", "Vision", "Wnt signaling pathway", "Xylose metabolism", "Zinc transport", "mRNA capping", "mRNA processing", "mRNA splicing", "mRNA transport", "rRNA processing", "tRNA processing"], "available_proteins": ["AAAS", "AAMP", "AAR2", "AARS", "AARS2", "ABCB1", "ABCB7", "ABCC1", "ABCD3", "ABCE1", "ABCF3", "ABHD12", "ABHD6", "ABI1", "ACAA2", "ACACA", "ACACB", "ACAD11", "ACADM", "ACADVL", "ACAT1", "ACBD3", "ACBD5", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT7", "ACOX1", "ACOX3", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN4", "ACTR3", "ADAR", "ADI1", "ADNP", "ADPGK", "ADPRHL2", "ADSL", "ADSS", "AFDN", "AGL", "AGPAT1", "AGPAT5", "AGPS", "AHCY", "AHCYL1", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AKAP8", "AKAP8L", "AKT2", "ALDH18A1", "ALDH3A2", "ALDH4A1", "ALDOA", "ALDOC", "ALKBH5", "ANAPC1", "ANAPC16", "ANAPC2", "ANAPC5", "ANAPC7", "ANKFY1", "ANKLE2", "ANKRD17", "ANO6", "ANP32B", "ANXA1", "ANXA11", "ANXA2", "AP1B1", "AP1G1", "AP1M1", "AP1S2", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "AP3S1", "APEX1", "API5", "APOL2", "APOO", "APP", "APRT", "AQR", "ARCN1", "ARF4", "ARF6", "ARFGAP1", "ARFGAP2", "ARFIP2", "ARGLU1", "ARHGEF2", "ARID1A", "ARID3B", "ARIH1", "ARIH2", "ARL2", "ARL3", "ARL6IP1", "ARMC10", "ARMT1", "ASAH1", "ASCC2", "ASCC3", "ASNA1", "ASNS", "ATAD2", "ATE1", "ATG3", "ATG4B", "ATG7", "ATG9A", "ATIC", "ATP13A1", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1D", "ATP6V1E1", "ATP6V1H", "ATP7B", "ATRIP", "AUP1", "AURKA", "AURKB", "BABAM1", "BAG6", "BAK1", "BANF1", "BANP", "BAZ1A", "BAZ1B", "BCAP31", "BCAS2", "BCCIP", "BCL2L13", "BCLAF1", "BICD2", "BIRC6", "BMS1", "BNIP1", "BOD1", "BOP1", "BRAP", "BRAT1", "BRD2", "BRIX1", "BSG", "BTF3", "BUB1B", "BUB3", "BUD23", "BUD31", "BYSL", "BZW1", "BZW2", "C1QBP", "C2CD5", "CACUL1", "CACYBP", "CAD", "CAMK1", "CAMK2G", "CAND1", "CANX", "CAPRIN1", "CARM1", "CARS", "CARS2", "CBX3", "CBX5", "CBX8", "CCAR1", "CCAR2", "CCDC124", "CCDC22", "CCDC86", "CCNB1", "CD2AP", "CD2BP2", "CD47", "CDC123", "CDC16", "CDC20", "CDC23", "CDC27", "CDC34", "CDC40", "CDC42", "CDC5L", "CDC7", "CDC73", "CDCA2", "CDCA8", "CDH2", "CDIPT", "CDK1", "CDK2", "CDK4", "CDK5", "CDK5RAP3", "CDK6", "CDKAL1", "CDS2", "CEBPZ", "CELF2", "CENPV", "CEP290", "CEP55", "CERS1", "CERS2", "CETN2", "CFL1", "CHAF1A", "CHAF1B", "CHCHD3", "CHD1", "CHD1L", "CHD4", "CHID1", "CHKA", "CHMP1A", "CHMP2A", "CHMP2B", "CHMP3", "CHMP4B", "CHMP5", "CHMP7", "CHORDC1", "CHST14", "CHTF18", "CIAPIN1", "CIRBP", "CISD2", "CKAP2", "CKAP5", "CLASP1", "CLCC1", "CLCN3", "CLCN7", "CLIC1", "CLIC4", "CLINT1", "CLPTM1", "CLPTM1L", "CLTA", "CLTC", "CLU", "CMPK1", "CMTR1", "CNNM3", "CNNM4", "CNOT1", "CNOT10", "CNOT11", "CNOT2", "CNOT9", "COASY", "COG3", "COMMD1", "COMT", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS6", "COPS7A", "COPZ1", "COQ8A", "COQ9", "CORO7", "COX2", "CPNE1", "CPOX", "CPSF1", "CPSF2", "CPSF3", "CPSF6", "CPSF7", "CPT1A", "CPT2", "CRNKL1", "CROT", "CS", "CSE1L", "CSK", "CSNK1A1", "CSNK2A2", "CSNK2B", "CSRP2", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTCF", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTPS2", "CTR9", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CWC15", "CYB5B", "CYB5D2", "CYB5R1", "CYB5R3", "CYC1", "CYFIP1", "CYFIP2", "CYP51A1", "DAD1", "DAG1", "DAP3", "DARS", "DARS2", "DAXX", "DAZAP1", "DBN1", "DBNL", "DCAF13", "DCAF16", "DCAF7", "DCP1B", "DCPS", "DCTD", "DCTN1", "DCTN3", "DCUN1D1", "DCXR", "DDB1", "DDRGK1", "DDT", "DDX1", "DDX17", "DDX20", "DDX21", "DDX23", "DDX28", "DDX39A", "DDX39B", "DDX3X", "DDX41", "DDX46", "DDX47", "DDX5", "DDX51", "DDX54", "DDX56", "DEGS1", "DENR", "DERL1", "DERL2", "DFFA", "DHCR24", "DHCR7", "DHFR", "DHPS", "DHX15", "DHX16", "DHX29", "DHX30", "DHX36", "DHX38", "DHX8", "DHX9", "DIABLO", "DIAPH1", "DIAPH2", "DIDO1", "DIMT1", "DIS3", "DKC1", "DLAT", "DLGAP5", "DLST", "DNAAF5", "DNAJA3", "DNAJB1", "DNAJC13", "DNAJC19", "DNAJC2", "DNAJC3", "DNM1L", "DNM2", "DNMT1", "DNPH1", "DNTTIP2", "DOCK7", "DOHH", "DPYSL2", "DSC3", "DSG2", "DST", "DTYMK", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNC1LI2", "DYNLL2", "EARS2", "EBNA1BP2", "ECD", "ECH1", "ECHS1", "ECI1", "ECSIT", "EDF1", "EDRF1", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EFL1", "EFTUD2", "EHD1", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B5", "EIF2D", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAC2", "ELMO2", "ELMOD2", "ELOA", "ELOB", "ELOC", "ELP1", "ELP2", "ELP3", "EMC4", "EMG1", "EML4", "ENO1", "ENO2", "ENOPH1", "EPB41", "EPB41L2", "EPB41L3", "EPHA7", "EPHX1", "EPHX2", "EPRS", "EPS15L1", "ERAL1", "ERAP1", "ERC1", "ERCC2", "ERCC3", "ERCC6L", "ERGIC2", "ERGIC3", "ERH", "ERLIN1", "ERLIN2", "ERO1A", "ERP44", "ESF1", "ESPL1", "ESYT1", "ESYT2", "ETF1", "ETFA", "ETFB", "ETFDH", "ETNK1", "EWSR1", "EXO1", "EXOC2", "EXOC3", "EXOC5", "EXOC6", "EXOC6B", "EXOC7", "EXOC8", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC9", "EZR", "F11R", "FABP5", "FADS2", "FAF1", "FAF2", "FAH", "FAM162A", "FAM208A", "FAM50A", "FANCD2", "FANCI", "FAR1", "FARS2", "FARSA", "FARSB", "FASN", "FASTKD2", "FBL", "FBXO21", "FBXO22", "FDFT1", "FDPS", "FDXR", "FECH", "FEN1", "FERMT2", "FGFR1OP", "FH", "FHL1", "FIP1L1", "FIS1", "FKBP8", "FLII", "FLNA", "FLNB", "FLOT2", "FMR1", "FOXRED1", "FTL", "FTSJ3", "FUBP1", "FUBP3", "FXR1", "G3BP1", "G3BP2", "G6PD", "GABARAPL2", "GADD45GIP1", "GAK", "GALK1", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GATAD2B", "GBA", "GBE1", "GBF1", "GCC2", "GCLC", "GCN1", "GEMIN4", "GEMIN5", "GET4", "GFM1", "GFPT1", "GGPS1", "GHITM", "GINS2", "GINS3", "GINS4", "GM2A", "GMPS", "GNAI2", "GNAI3", "GNL2", "GNL3L", "GNPDA1", "GOLGA2", "GOLIM4", "GOLPH3", "GOLT1B", "GOPC", "GORASP2", "GOSR1", "GOT1", "GOT2", "GPAA1", "GPAM", "GPAT4", "GPHN", "GPI", "GPKOW", "GPR89B", "GRAMD1A", "GRB2", "GRIPAP1", "GRSF1", "GRWD1", "GSPT1", "GSS", "GTF2B", "GTF2E1", "GTF2F1", "GTF2I", "GTF3C1", "GTF3C2", "GTF3C3", "GTPBP10", "GTPBP3", "GTPBP4", "GUF1", "GYG1", "GYS1", "H2AFX", "HACD2", "HACD3", "HACL1", "HADH", "HADHA", "HADHB", "HAUS1", "HAUS3", "HAUS4", "HAUS5", "HBS1L", "HCFC1", "HDAC1", "HDAC2", "HDGF", "HDLBP", "HEATR1", "HECTD1", "HELLS", "HGS", "HIBADH", "HIBCH", "HIKESHI", "HINT2", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLTF", "HMBS", "HMCES", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMGCR", "HMGCS1", "HMOX1", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH3", "HNRNPK", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HPRT1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSP90AA1", "HSP90AB1", "HSPA1B", "HSPA2", "HSPA4", "HSPA4L", "HSPA8", "HSPB1", "HSPD1", "HSPE1", "HSPH1", "HTATSF1", "HTRA2", "HUS1", "HUWE1", "HYOU1", "IARS", "IARS2", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDI1", "IFT27", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IK", "IKBKG", "ILF2", "ILF3", "ILVBL", "IMP3", "IMP4", "IMPDH1", "IMPDH2", "INA", "INCENP", "INTS3", "INTS7", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IST1", "ITCH", "ITGB1", "ITPA", "IVD", "JAGN1", "JUP", "KARS", "KAT7", "KCTD5", "KDELR1", "KDM1A", "KDM1B", "KDM2A", "KDM3B", "KDSR", "KHDRBS1", "KHSRP", "KIAA0319L", "KIAA0391", "KIAA1468", "KIF11", "KIF18B", "KIF20A", "KIF23", "KIF2A", "KIF2C", "KIFBP", "KIFC1", "KIN", "KLC1", "KMT2A", "KNTC1", "KPNA1", "KPNA2", "KPNA3", "KPNA6", "KPNB1", "KRR1", "LAMP1", "LAMP2", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LAS1L", "LASP1", "LBR", "LDAH", "LETM1", "LGALS3BP", "LIG1", "LIG3", "LIMA1", "LIPA", "LMAN2", "LPCAT1", "LPCAT3", "LPGAT1", "LRP1", "LRPPRC", "LRWD1", "LSM2", "LSM3", "LSM4", "LSM6", "LSM7", "LSS", "LTA4H", "LYAR", "LYPLA1", "M6PR", "MACF1", "MAD2L1", "MAGT1", "MANF", "MAP1S", "MAPK1", "MAPK14", "MAPRE1", "MAPRE2", "MARCH5", "MARS", "MASTL", "MAT2A", "MAT2B", "MATR3", "MAU2", "MAVS", "MBD3", "MBOAT7", "MCAT", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCMBP", "MCTS1", "MCU", "MCUR1", "MDC1", "MDH1", "MDH2", "MECP2", "MED21", "MED23", "MED24", "MED25", "METTL14", "METTL3", "MFN2", "MFSD3", "MFSD5", "MGEA5", "MGME1", "MGST2", "MIA3", "MICU1", "MIF", "MINDY3", "MKI67", "MKRN2", "MLEC", "MMS19", "MOB4", "MORF4L1", "MOSPD2", "MOV10", "MPC2", "MPDU1", "MPG", "MPHOSPH10", "MRC2", "MRE11", "MRPL58", "MRPS27", "MRRF", "MRTO4", "MSH2", "MSH3", "MSH6", "MSMO1", "MSN", "MTA1", "MTAP", "MTBP", "MTCH1", "MTCH2", "MTFP1", "MTHFD1L", "MTHFD2", "MTMR2", "MTOR", "MTPAP", "MTR", "MTX1", "MTX2", "MVK", "MYBBP1A", "MYCBP", "MYDGF", "MYH10", "MYH9", "MYO1C", "MYO1D", "MYO6", "NAA15", "NAE1", "NAF1", "NAMPT", "NAP1L1", "NAPA", "NAPG", "NARS", "NASP", "NAT10", "NAXE", "NCAPD2", "NCAPD3", "NCAPG", "NCAPG2", "NCAPH", "NCBP1", "NCBP3", "NCKAP1", "NCSTN", "ND1", "NDC1", "NDUFA11", "NDUFA13", "NDUFA4", "NDUFA5", "NDUFA7", "NDUFA8", "NDUFA9", "NDUFAF4", "NDUFB1", "NDUFB10", "NDUFB3", "NDUFB4", "NDUFB5", "NDUFB6", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS6", "NDUFS7", "NDUFS8", "NDUFV1", "NDUFV2", "NECAP2", "NEK9", "NELFCD", "NELFE", "NES", "NGDN", "NHP2", "NIP7", "NKRF", "NLE1", "NLRX1", "NME1", "NOA1", "NOC2L", "NOL11", "NOL8", "NOL9", "NONO", "NOP14", "NOP2", "NOP53", "NOP56", "NOP58", "NOSIP", "NPC1", "NPC2", "NPLOC4", "NPM1", "NSA2", "NSD2", "NSDHL", "NSF", "NSMCE2", "NSUN2", "NSUN5", "NT5C2", "NT5C3B", "NTHL1", "NUBP2", "NUCKS1", "NUDC", "NUDCD1", "NUDT21", "NUF2", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP160", "NUP188", "NUP205", "NUP210", "NUP214", "NUP35", "NUP37", "NUP43", "NUP50", "NUP54", "NUP58", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NUTF2", "NVL", "NXF1", "NXN", "OCRL", "OGDH", "OGT", "OPA1", "OPA3", "OSBP", "OSBPL3", "OSBPL6", "OSBPL8", "OSBPL9", "OSGEP", "OTUB1", "OTUD4", "OTUD7B", "PA2G4", "PABPC1", "PABPN1", "PACSIN2", "PAF1", "PAFAH1B1", "PAFAH1B2", "PAFAH1B3", "PAICS", "PAIP1", "PAIP2", "PAK1IP1", "PAK2", "PANK4", "PAPOLA", "PARG", "PARK7", "PARN", "PARP1", "PAWR", "PBRM1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCID2", "PCK2", "PCLAF", "PCM1", "PCNA", "PCNP", "PDCD11", "PDCD5", "PDCD6", "PDCD6IP", "PDCL3", "PDE12", "PDE6D", "PDHA1", "PDHB", "PDK3", "PDLIM7", "PDS5A", "PDS5B", "PECR", "PELO", "PELP1", "PEPD", "PES1", "PEX11A", "PEX14", "PEX16", "PEX19", "PEX5", "PFAS", "PFKL", "PFKM", "PFKP", "PGAM1", "PGAM5", "PGD", "PGK1", "PGM1", "PGM2", "PGM3", "PGP", "PHAX", "PHB", "PHB2", "PHF5A", "PHF6", "PHGDH", "PHKA1", "PI4KB", "PIBF1", "PICALM", "PIGK", "PIGS", "PIGT", "PIGU", "PIR", "PISD", "PITHD1", "PITPNB", "PKM", "PKMYT1", "PKN1", "PKN2", "PLA2G15", "PLAA", "PLBD2", "PLCG1", "PLD3", "PLD6", "PLIN3", "PLK1", "PLRG1", "PMF1", "PMVK", "PNKP", "PNN", "PNP", "PNPLA6", "PNPT1", "PODXL", "POFUT1", "POGZ", "POLA1", "POLA2", "POLD1", "POLD2", "POLD3", "POLDIP2", "POLDIP3", "POLE", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2B", "POLR2C", "POLR2D", "POLR2E", "POLR2F", "POLR2G", "POLR2L", "POLR3A", "POLR3C", "POLRMT", "POP1", "PPAT", "PPID", "PPIF", "PPIH", "PPIL1", "PPIL3", "PPOX", "PPP1CA", "PPP1CB", "PPP1R8", "PPP2R1A", "PPP5C", "PPP6C", "PPT1", "PPWD1", "PRAF2", "PRC1", "PRCC", "PRDX6", "PREB", "PRIM1", "PRIM2", "PRKAA2", "PRKAG1", "PRKCB", "PRKDC", "PRKRA", "PRMT5", "PRPF19", "PRPF31", "PRPF38B", "PRPF39", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPSAP1", "PRPSAP2", "PSAP", "PSAT1", "PSIP1", "PSMA1", "PSMA3", "PSMA4", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC3", "PSMD10", "PSMD14", "PSME3", "PSME4", "PSPC1", "PTBP1", "PTCD3", "PTDSS1", "PTGES2", "PTGES3", "PTGR1", "PTK7", "PTPMT1", "PTPRF", "PTRH2", "PUDP", "PUF60", "PUM1", "PURA", "PUS7", "PWP1", "PXN", "PYCR1", "PYCR2", "PYCR3", "PYGB", "PYGL", "QARS", "QKI", "QRSL1", "QTRT2", "RAB10", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB1B", "RAB21", "RAB24", "RAB39A", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RAB8A", "RAB9A", "RABEP1", "RABGAP1", "RACGAP1", "RACK1", "RAD21", "RAD23A", "RAD23B", "RAD50", "RAE1", "RAI14", "RALA", "RALY", "RAN", "RANBP2", "RANBP3", "RANBP6", "RAPGEF2", "RARS", "RARS2", "RBBP5", "RBBP6", "RBBP7", "RBM10", "RBM14", "RBM17", "RBM22", "RBM25", "RBM28", "RBM39", "RBM4", "RBM5", "RBM8A", "RBMX", "RBP1", "RCC1", "RCC2", "RCL1", "REEP4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RFT1", "RIF1", "RINT1", "RMC1", "RMDN3", "RMND1", "RNASET2", "RNF139", "RNF14", "RNF20", "RNF219", "RNF40", "ROCK1", "RPA1", "RPA2", "RPAP1", "RPF1", "RPF2", "RPL10", "RPL13A", "RPP30", "RPRD1B", "RPS3", "RPS3A", "RPS6KA1", "RPS6KA3", "RPSA", "RPTOR", "RPUSD3", "RRBP1", "RRM1", "RRM2", "RRP1", "RRP1B", "RRP36", "RRP8", "RRP9", "RRS1", "RSL24D1", "RTCB", "RTN3", "RTN4", "RTN4IP1", "RTRAF", "RUFY1", "RUVBL1", "RUVBL2", "S100A13", "SAE1", "SAFB", "SAFB2", "SAMD4B", "SAMHD1", "SAP18", "SAR1A", "SARM1", "SARNP", "SARS", "SARS2", "SART1", "SART3", "SBDS", "SCAF1", "SCAF4", "SCAMP1", "SCAMP2", "SCAMP3", "SCARB1", "SCARB2", "SCD", "SCFD1", "SCML2", "SCP2", "SCRIB", "SCRN1", "SDAD1", "SDF4", "SDHA", "SDHB", "SEC16A", "SEC22B", "SEC23A", "SEC23B", "SEC24A", "SEC24B", "SEC24C", "SEC24D", "SEC31A", "SEC61A1", "SEC61B", "SEC61G", "SEC62", "SEC63", "SEH1L", "SEL1L", "SENP3", "SEPT11", "SEPT2", "SEPT6", "SEPT7", "SEPT9", "SERPINH1", "SET", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFXN1", "SFXN2", "SFXN4", "SGPL1", "SGTA", "SH3GL1", "SH3GLB1", "SHMT1", "SHMT2", "SIGMAR1", "SIN3A", "SIRT1", "SKIV2L2", "SKP1", "SKP2", "SLC12A9", "SLC16A1", "SLC19A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A17", "SLC25A19", "SLC25A20", "SLC25A21", "SLC25A22", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A33", "SLC25A4", "SLC25A40", "SLC25A42", "SLC25A5", "SLC25A6", "SLC27A4", "SLC30A5", "SLC30A6", "SLC33A1", "SLC35B2", "SLC35F2", "SLC39A14", "SLC3A2", "SLC4A7", "SLC6A15", "SLC9A3R1", "SLFN11", "SLIRP", "SLIT2", "SLK", "SLTM", "SMARCA1", "SMARCA4", "SMARCAD1", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC6", "SMG5", "SMN1*", "SMNDC1", "SMS", "SMU1", "SNAP23", "SND1", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNW1", "SNX1", "SNX12", "SNX17", "SNX19", "SNX2", "SNX27", "SNX3", "SNX4", "SNX5", "SNX6", "SNX9", "SOAT1", "SON", "SPATA5", "SPC24", "SPC25", "SPECC1L", "SPEN", "SPNS1", "SPTLC1", "SPTLC2", "SQSTM1", "SRCAP", "SREK1", "SRM", "SRPK1", "SRPK2", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF3", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSBP1", "SSRP1", "STAG1", "STAG2", "STAM", "STAMBP", "STARD3", "STAT1", "STAT3", "STAU1", "STAU2", "STIM1", "STK26", "STK4", "STMN1", "STRAP", "STRBP", "STX10", "STX12", "STX18", "STX3", "STX4", "STX5", "STX8", "STXBP3", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGP2", "SUGT1", "SUN1", "SUN2", "SUPT16H", "SUPT5H", "SUPT6H", "SUZ12", "SV2A", "SYAP1", "SYMPK", "SYNCRIP", "SYNGR2", "SYS1", "TACC3", "TADA3", "TAF6L", "TALDO1", "TAOK1", "TAP1", "TARDBP", "TARS", "TARS2", "TBCB", "TCAF1", "TCEA1", "TCERG1", "TDRKH", "TECR", "TERF2IP", "TEX264", "TFAM", "TFB1M", "TFCP2", "TFG", "TFIP11", "TFRC", "THOC1", "THOC2", "THOC3", "THOC5", "THOC6", "THRAP3", "TIA1", "TIAL1", "TIGAR", "TIMELESS", "TIMM10", "TIMM10B", "TIMM13", "TIMM17A", "TIMM17B", "TIMM23", "TIMM44", "TIMM50", "TIMM8B", "TIMM9", "TK1", "TLN1", "TMCO1", "TMED10", "TMED2", "TMED4", "TMED5", "TMED7", "TMED9", "TMEM109", "TMEM14C", "TMEM214", "TMEM30A", "TMEM38B", "TMEM59", "TMF1", "TMX1", "TMX4", "TNPO1", "TNPO2", "TNPO3", "TOMM20", "TOMM22", "TOMM40", "TOMM5", "TOMM70", "TOP1", "TOP2A", "TP53", "TPI1", "TPR", "TPX2", "TRA2A", "TRA2B", "TRAF2", "TRAM1", "TRAPPC5", "TRIM21", "TRIM25", "TRIM28", "TRIM33", "TRIP12", "TRIP13", "TRMT10C", "TRMT11", "TRMT1L", "TRMU", "TROVE2", "TRRAP", "TSFM", "TSG101", "TSNAX", "TSR1", "TTC19", "TTC26", "TTC4", "TTLL12", "TTYH3", "TUBB2B", "TUFM", "TWF2", "TWISTNB", "TWNK", "TXLNA", "TXLNG", "TXNL1", "TXNRD1", "TYMS", "U2AF1", "U2AF2", "UBA1", "UBA2", "UBA3", "UBA6", "UBAC1", "UBE2J1", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2O", "UBE2S", "UBE3A", "UBE4A", "UBE4B", "UBP1", "UBQLN2", "UBQLN4", "UBR4", "UBR5", "UBTF", "UBXN1", "UBXN4", "UCHL5", "UFC1", "UFD1", "UFL1", "UFM1", "UGCG", "UGT8", "UHRF1", "ULK3", "UMPS", "UNC119", "UNC119B", "UNC45A", "UNG", "UPF1", "UQCR10", "UQCRB", "UQCRC1", "UQCRC2", "UQCRQ", "UROD", "USO1", "USP10", "USP11", "USP14", "USP28", "USP36", "USP39", "USP47", "USP48", "USP5", "USP7", "USP9X", "UTP11", "UTP14A", "UTP15", "UTP18", "UTP20", "UTP4", "UTP6", "UXT", "VAMP7", "VAPA", "VAPB", "VARS1", "VCL", "VCP", "VDAC1", "VDAC2", "VDAC3", "VIM", "VIRMA", "VMP1", "VPS13A", "VPS16", "VPS18", "VPS26A", "VPS29", "VPS33A", "VPS33B", "VPS35", "VPS37B", "VPS4A", "VPS4B", "VPS51", "VPS52", "VPS53", "VRK1", "WAPL", "WARS", "WASHC5", "WBP11", "WDR12", "WDR36", "WDR41", "WDR43", "WDR48", "WDR5", "WDR6", "WDR61", "WDR75", "WIPI2", "WLS", "XAB2", "XPO1", "XPO4", "XPO5", "XPO7", "XPOT", "XRCC1", "XRCC5", "XRCC6", "XRN2", "YARS", "YARS2", "YBX1", "YBX3", "YIF1A", "YIPF3", "YIPF4", "YIPF5", "YKT6", "YLPM1", "YTHDC1", "YTHDC2", "YTHDF3", "YWHAB", "YWHAE", "ZC3H11A", "ZC3HAV1", "ZC3HC1", "ZCCHC3", "ZCRB1", "ZMYM2", "ZNF207", "ZNF280C", "ZNF281", "ZNF318", "ZNF326", "ZNF512", "ZNF512B", "ZNF638", "ZPR1", "ZRANB2", "ZW10", "ZWINT", "ZYX"], "leading_proteins": ["AAAS", "ABCB1", "ABCB7", "ABCC1", "ABCD3", "ABHD12", "ACOX1", "ACOX3", "AGPAT5", "AGPS", "AIFM1", "AKT2", "ALDH18A1", "ALDH3A2", "ANO6", "ANXA1", "APOL2", "APOO", "ARF4", "ARL6IP1", "ASAH1", "ASNA1", "ATP13A1", "ATP1A1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP5F1", "ATP5I", "ATP5L", "ATP6", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP7B", "BAG6", "BCAP31", "BNIP1", "C1QBP", "CDIPT", "CDS2", "CERS1", "CERS2", "CETN2", "CLCC1", "CLCN3", "CLCN7", "CLPTM1L", "CNNM3", "CNNM4", "COMMD1", "COQ9", "COX2", "CPT2", "CYB5B", "CYC1", "CYP51A1", "DEGS1", "DERL1", "DERL2", "DHCR24", "DHCR7", "DIABLO", "DNAJC19", "DNM1L", "ELMO2", "EMC4", "ENOPH1", "ERAP1", "ERGIC2", "ERGIC3", "ERLIN1", "FADS2", "FAM162A", "FASN", "FDFT1", "FOXRED1", "GBA", "GBE1", "GHITM", "GM2A", "GOLIM4", "GOLPH3", "GOLT1B", "GOSR1", "GPAA1", "GYG1", "GYS1", "HACD2", "HACD3", "HADHA", "HIKESHI", "HLA-A", "HLA-B", "HLA-C", "HMOX1", "HNRNPA2B1", "HSD17B11", "HSD17B12", "ILVBL", "IPO9", "JAGN1", "KDELR1", "KDSR", "KHSRP", "KMT2A", "KPNA2", "KPNA3", "LBR", "LDAH", "LETM1", "LMAN2", "LPCAT1", "LPGAT1", "MAGT1", "MAPK14", "MBOAT7", "MCUR1", "MFSD3", "MGST2", "MIF", "MOB4", "MSMO1", "MTCH1", "MTCH2", "MTFP1", "MTX1", "NASP", "NCSTN", "ND1", "NDC1", "NDUFA11", "NDUFA13", "NDUFA8", "NDUFB1", "NDUFB10", "NDUFB3", "NDUFB4", "NDUFB5", "NDUFB6", "NDUFB9", "NPC1", "NUP107", "NUP205", "NUP35", "NUP54", "NUP88", "NUP93", "NXF1", "OPA1", "OPA3", "PDCD5", "PDE6D", "PECR", "PEX14", "PEX16", "PEX19", "PGAM5", "PIGU", "PISD", "PLA2G15", "PLBD2", "PLD3", "PLD6", "PNPLA6", "PPT1", "PRAF2", "PREB", "PSAP", "PTGES2", "PTPMT1", "PUF60", "PYCR2", "PYCR3", "RAB10", "RAB1A", "RAB1B", "RAB24", "RAB5A", "RAB9A", "RAE1", "RFT1", "RTN3", "S100A13", "SAR1A", "SCAMP2", "SCAMP3", "SCD", "SDHB", "SEC22B", "SEC23A", "SEC23B", "SEC61G", "SEC62", "SEL1L", "SFXN1", "SFXN2", "SFXN4", "SGPL1", "SH3GLB1", "SIGMAR1", "SLC16A1", "SLC19A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A12", "SLC25A13", 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file mode 100644 index 0000000000000000000000000000000000000000..ea4c12e72e572f71e409c1c47a3e68430fdf890b --- /dev/null +++ b/protein_atlas_disease_involvement/df_merge.tsv @@ -0,0 +1,4 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Primary mitochondrial disease 35 85 3.747374770713573 0.0001786949998687 27.53640776699029 92.44660194174756 0.9978626953080288 0.3665723479658412 11.863754653333944 10.66022291187525 1.7959996823414457 0.3879563837717744 9.548807409721493e-09 0.0011826603259271 0.0010405769745358 2.119294702189068e-06 1.7808873574286955e-08 +Congenital disorder of glycosylation 10 20 2.669926488052041 0.0075867855042111 5.618932038834951 18.325242718446603 0.4013656328493284 0.4500757016048167 2.8520016519219875 3.440343696044481 1.1296344785223882 0.3186521023843959 4.251521957873979e-06 0.0196403757049561 0.0681167311872175 0.0040714376200731 5.640751162886056e-06 +Ichthyosis 1 7 2.0191721970583187 0.0434693249988247 2.424757281553398 8.70873786407767 0.6701903086786922 0.3798909770564678 1.5631275250389387 1.4270688811262522 1.102920967881483 0.3152318826682235 0.3376138879681183 0.1178616319260966 0.0251008323038497 0.1258256892179061 0.3508562959456769 diff --git a/protein_atlas_disease_involvement/metrics.json b/protein_atlas_disease_involvement/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..630138c284dedac3f24c9a40852205e9889554a5 --- /dev/null +++ b/protein_atlas_disease_involvement/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2974, + "annotations_size": 116, + "title": "Average number of proteins per term", + "value": 20.267241379310345 +} \ No newline at end of file diff --git a/protein_atlas_disease_involvement/paths.json b/protein_atlas_disease_involvement/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..d48e59cf6eac35624508b955df75d4e06954c43d --- /dev/null +++ b/protein_atlas_disease_involvement/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/protein_atlas_disease_involvement/fragment/C220/C220_val_log2fc"} \ No newline at end of file diff --git a/protein_atlas_disease_involvement/result.tsv b/protein_atlas_disease_involvement/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..9631cef6301c56e2ea03d18a93729fe33d7ee48f --- /dev/null +++ b/protein_atlas_disease_involvement/result.tsv @@ -0,0 +1,42 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Primary mitochondrial disease 0.5473974112923694 3.747374770713573 0.0001786949998687 0.0205170731809803 0.0207286199847783 85 Q9Y2R0,Q53H12,P13073,Q9UMS0,Q86Y39,Q9BRT2,P00403,Q70HW3,Q9UBX3,P00846,Q9Y6M9,O43676,O95831,Q5JTZ9,O14949,Q00059,Q96CU9,Q9BQT8,Q9P0J0,Q6DKK2,Q07021,O43819,P03886,Q9NWS8,Q8IUX1,O60313,O75880,Q5XKP0,P08574,Q99797,P12235,Q9BW92,O75208,Q6P4A7,P22695 35 +Congenital disorder of glycosylation 0.6005001371318747 2.669926488052041 0.0075867855042111 0.586634273160618 0.1349001361963737 20 P46977,Q15904,Q9HC07,Q96AA3,Q9H3H5,Q9H0U3,Q8N511,Q9BV10,Q9BT22,P51571 10 +Ichthyosis 0.7447868249604219 2.0191721970583187 0.0434693249988247 0.994231370716466 0.3151526062414792 7 P04062 1 +Dystonia 0.8521885521885564 1.923439357739953 0.0544248955045751 0.9984838596358784 0.3581149036469029 4 P35270,Q15043,O75569 3 +Gaucher disease 0.9848586810228804 1.9002002508714515 0.0574068453826861 0.9989489662795528 0.3581149036469029 2 P04062 1 +Cataract 0.4708912191649321 1.890757285965088 0.0586567514594065 0.9990989074343716 0.3581149036469029 27 Q53H12,O00400,Q15800,O76024,Q9H6K4,P08670,O00116,Q9UG56 8 +Leber hereditary optic neuropathy 0.9687079407806204 1.8321903657287593 0.0669230637389586 0.9996760897101206 0.38815376968596 2 P00846 1 +Gangliosidosis 0.7230425952323162 1.6350074024103325 0.1020474958531765 0.999996220882053 0.495483153772926 5 P17900,P16278,P07602 3 +Neuronal ceroid lipofuscinosis 0.9134971390104276 1.5551567185362687 0.1199087494631805 0.999999632537013 0.495483153772926 3 O14773,P50897 2 +Hereditary spastic paraplegia 0.5137373793507325 1.5504541408154835 0.121032552392218 0.9999996831572328 0.495483153772926 15 Q15041,O00400,Q8IY17,O75298 4 +Zellweger syndrome 0.7646464646464747 1.546306062898957 0.1220306684227803 0.9999997222819468 0.495483153772926 4 O75381,P40855,Q9Y5Y5 3 +Peroxisome biogenesis disorder 0.7646464646464747 1.546306062898957 0.1220306684227803 0.9999997222819468 0.495483153772926 4 O75381,P40855,Q9Y5Y5 3 +Leigh syndrome 0.6326655309960318 1.5218435677825328 0.1280482819368209 0.9999998749387466 0.495483153772926 8 P00846 1 +Cone-rod dystrophy 0.8512786002691877 1.333431686447737 0.1823901797637852 0.9999999999283284 0.6061598196292958 2 Q13432 1 +Congenital myasthenic syndrome 0.7121676445543822 1.3161653085773124 0.18811856471254 0.999999999968294 0.6061598196292958 4 Q9H3H5,P53007 2 +Lissencephaly 0.5575823741517424 1.2560851645116669 0.2090850943076265 0.9999999999984758 0.618240619719637 9 Q6ZXV5,O43505 2 +Ehlers-Danlos syndrome 0.6936580183326484 1.2346613651583636 0.2169565603102112 0.9999999999995224 0.618240619719637 4 Q9NWM8 1 +Deafness 0.3655498035262117 1.2339593290205326 0.2172180598497697 0.9999999999995404 0.618240619719637 47 Q969T9,O00400,O60313,O95831,Q9NWM8,Q16740,Q15067,O76024,Q9NR28,Q9UG56,P33527 11 +Mucopolysaccharidosis 0.6928527632248122 1.2311147219454106 0.2182799601192071 0.9999999999996074 0.618240619719637 4 P54802,P16278 2 +Cardiomyopathy 0.3870104611386291 1.058357175266913 0.2898926355919244 1.0 0.7472787939702942 23 P50402,Q53H12,P00846,Q96DA6,O60313,Q5JTZ9,P12235,O43819 8 +Hirschsprung disease 0.7190444145356767 0.7855174294677176 0.4321502553026048 1.0 0.9016706299317058 2 P42892 1 +Diabetes mellitus 0.4718011694716277 0.7832013378606727 0.4335088893972716 1.0 0.9016706299317058 9 O76024,P03886 2 +Parkinsonism 0.4242759744349946 0.7801726310805872 0.4352892696222028 1.0 0.9016706299317058 12 Q96A57,Q15043,P04062 3 +Rhizomelic chondrodysplasia punctata 0.7011107371255345 0.7214242894928313 0.4706485067150328 1.0 0.921334930469939 3 O00116,P50542 2 +FDA approved drug targets 0.322934937381153 0.6951008358484584 0.4869921109924542 1.0 0.921334930469939 114 P35610,Q8N0U8,P49354,P05023,Q13423,P05141,Q7L0J3,P38435,Q14534,Q16850,P33527,P49721,P23786,P16615,P12236,P49327,P10253,Q16739,P03886,P12235,P62942,P21964,P00374 23 +Parkinson disease 0.4318053648311157 0.4817395182504517 0.6299909992591031 1.0 0.9997929562356234 8 P04062 1 +Amyloidosis 0.513332330356043 0.4718058248371688 0.6370653928905938 1.0 0.9997929562356234 4 P03886 1 +Alzheimer disease 0.513332330356043 0.4718058248371688 0.6370653928905938 1.0 0.9997929562356234 4 P03886 1 +Epilepsy 0.2632888362911029 0.38162352352961 0.7027406332451802 1.0 0.9997929562356234 63 Q13510,O75503,O14773,P27544,P17050,Q9H490,Q96RL7,Q14108,P16615,Q6PJG6,Q9H936,O43464,Q92643,Q3ZCQ8,P05023,P22466,P03886 17 +Leukodystrophy 0.323071404854617 0.3747862876813385 0.707819413051042 1.0 0.9997929562356234 18 O15121,P07602 2 +Non-syndromic deafness 0.3415037054487826 0.3726941030118894 0.7093761258845293 1.0 0.9997929562356234 15 Q969T9,Q9NR28,O76024 3 +Neurodegeneration 0.308615441391745 0.3502777689401616 0.7261302475573368 1.0 0.9997929562356234 130 O15269,O00400,O75503,P54802,Q10713,P50897,P05023,Q71SY5,P04062,O95831,Q8IV08,Q5JTZ9,Q99720,O14773,Q9Y320,P06865,P61026,Q13510,O75298,P03886,Q15041,Q96A57,P27544,Q16637,Q14108,O60313,Q15043,P35637,Q9NW15,Q9NSD9,Q8IY17,O75477 32 +Spinocerebellar ataxia 0.4006521731580528 0.3342555209328915 0.7381867511648148 1.0 0.9997929562356234 8 O14773 1 +Retinitis pigmentosa 0.3339215997485171 0.3248095072779599 0.745325248603238 1.0 0.9997929562356234 15 Q8IY17,P00846,Q96S66 3 +Nephronophthisis 0.5561911170928764 0.2438205073293599 0.8073698370137601 1.0 1.0 2 Q9NQH7 1 +Osteogenesis imperfecta 0.364016802278953 0.2321754145799947 0.8164017723770536 1.0 1.0 9 Q96AY3,O75718 2 +Emery-Dreifuss muscular dystrophy 0.3504963687065867 0.0596986200838526 0.952395670790272 1.0 1.0 5 P50402,Q9BTV4 2 +Primary microcephaly 0.2905219766896117 0.0266759064274783 0.9787182301780536 1.0 1.0 11 Q86XL3 1 +Holoprosencephaly 0.3990578734858662 0.0252501669459793 0.9798554222583812 1.0 1.0 2 A5YKK6 1 +Cushing syndrome 0.4146751935375254 0.0129420197320899 0.989674050529954 1.0 1.0 3 O00170,P10644 2 +Aicardi-Goutieres syndrome 0.4022214742510905 0.0034148204522431 0.9972753727785548 1.0 1.0 3 Q9Y3Z3,O75792 2 diff --git a/protein_atlas_disease_involvement/selections.json b/protein_atlas_disease_involvement/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..fb14ad07323a9b8f4e6faa6ae1c8fa080ff8fb30 --- /dev/null +++ b/protein_atlas_disease_involvement/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["Aicardi-Goutieres syndrome", "Albinism", "Allergen", "Alport syndrome", "Alzheimer disease", "Amelogenesis imperfecta", "Amyloidosis", "Amyotrophic lateral sclerosis", "Atrial fibrillation", "Autism", "Autism spectrum disorder", "Bardet-Biedl syndrome", "Bartter syndrome", "Cancer-related genes", "Cardiomyopathy", "Cataract", "Charcot-Marie-Tooth disease", "Ciliopathy", "Cockayne syndrome", "Cone-rod dystrophy", "Congenital adrenal hyperplasia", "Congenital disorder of glycosylation", "Congenital dyserythropoietic anemia", "Congenital hypothyroidism", "Congenital muscular dystrophy", "Congenital myasthenic syndrome", "Craniosynostosis", "Cushing syndrome", "Deafness", "Diabetes insipidus", "Diabetes mellitus", "Diamond-Blackfan anemia", "Disease variant", "Dwarfism", "Dyskeratosis congenita", "Dystonia", "Dystroglycanopathy", "Ectodermal dysplasia", "Ehlers-Danlos syndrome", "Elliptocytosis", "Emery-Dreifuss muscular dystrophy", "Epidermolysis bullosa", "Epilepsy", "FDA approved drug targets", "Fanconi anemia", "Gangliosidosis", "Gaucher disease", "Glaucoma", "Glutaricaciduria", "Glycogen storage disease", "Gout", "Hemolytic uremic syndrome", "Hereditary hemolytic anemia", "Hereditary nonpolyposis colorectal cancer", "Hereditary spastic paraplegia", "Hermansky-Pudlak syndrome", "Hirschsprung disease", "Holoprosencephaly", "Hypogonadotropic hypogonadism", "Hypotrichosis", "Ichthyosis", "Intrahepatic cholestasis", "Joubert syndrome", "Kallmann syndrome", "Kartagener syndrome", "Leber congenital amaurosis", "Leber hereditary optic neuropathy", "Leigh syndrome", "Leukodystrophy", "Li-Fraumeni syndrome", "Limb-girdle muscular dystrophy", "Lissencephaly", "Long QT syndrome", "MELAS syndrome", "Maple syrup urine disease", "Meckel syndrome", "Mental retardation", "Metachromatic leukodystrophy", "Microphthalmia", "Mucopolysaccharidosis", "Myofibrillar myopathy", "Nemaline myopathy", "Nephronophthisis", "Neurodegeneration", "Neuronal ceroid lipofuscinosis", "Neuropathy", "Niemann-Pick disease", "Non-syndromic deafness", "Obesity", "Oncogene", "Osteogenesis imperfecta", "Osteopetrosis", "Palmoplantar keratoderma", "Parkinson disease", "Parkinsonism", "Peroxisome biogenesis disorder", "Pontocerebellar hypoplasia", "Premature ovarian failure", "Primary ciliary dyskinesia", "Primary hypomagnesemia", "Primary microcephaly", "Primary mitochondrial disease", "Progressive external ophthalmoplegia", "Proto-oncogene", "Pyropoikilocytosis", "Retinitis pigmentosa", "Rhizomelic chondrodysplasia punctata", "SCID", "Schizophrenia", "Senior-Loken syndrome", "Spinocerebellar ataxia", "Systemic lupus erythematosus", "Tumor suppressor", "Williams-Beuren syndrome", "Xeroderma pigmentosum", "Zellweger syndrome"], "available_proteins": ["AAAS", "AARS", "AARS2", "ABCB1", "ABCB7", "ABCC1", "ABHD12", "ABI1", "ACAD9", "ACADM", "ACADVL", "ACAT1", "ACBD5", "ACLY", "ACO1", "ACO2", "ACOX1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN4", "ADAR", "ADD3", "ADNP", "ADPRHL2", "ADSL", "AFDN", "AFG3L2", "AGK", "AGL", "AGPS", "AHCY", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AKAP12", "AKAP13", "AKR1B1", "AKT2", "ALDH18A1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDOA", "ALDOC", "ALG1", "ALG11", "ALG12", "ANAPC1", "ANKLE2", "ANO10", "ANXA1", "ANXA11", "ANXA2", "ANXA3", "ANXA4", "ANXA7", "AP1B1", "AP1S2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "APEX1", "APOL2", "APP", "APRT", "ARAF", "ARCN1", "ARHGDIA", "ARHGEF2", "ARID1A", "ARID3B", "ARIH1", "ARL2", "ARL3", "ARL6IP1", "ASAH1", "ASNS", "ASPH", "ATAD1", "ATAD3A", "ATIC", "ATP1A1", "ATP2A2", "ATP2B1", "ATP5A1", "ATP6", "ATP6AP1", "ATP6AP2", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1E1", "ATP7B", "ATXN10", "AURKA", "AURKB", "B3GALT6", "B4GAT1", "BANF1", "BANP", "BAZ1B", "BCAP31", "BCLAF1", "BCS1L", "BICD2", "BIRC6", "BLMH", "BMS1", "BRAT1", "BRI3BP", "BUB1B", "BUD23", "C19orf70", "C1QBP", "C21orf59", "CAD", "CALM3", "CALR", "CAMK2G", "CANX", "CAPN1", "CARM1", "CARS", "CARS2", "CASK", "CAST", "CCAR1", "CCAR2", "CCDC22", "CCDC47", "CCDC6", "CCNB1", "CCT5", "CD320", "CDC16", "CDC20", "CDC27", "CDC34", "CDC37", "CDC42", "CDC73", "CDH2", "CDK1", "CDK2", "CDK4", "CDK5", "CDK6", "CDKAL1", "CEP290", "CEP55", "CERS1", "CFL2", "CHAMP1", "CHD1", "CHD4", "CHMP1A", "CHMP2B", "CHMP4B", "CHST14", "CISD2", "CKB", "CKMT1A*", "CLCC1", "CLCN7", "CLIC1", "CLN5", "CLPB", "CLPP", "CLPX", "CLTC", "CLU", "CNNM4", "CNOT1", "CNOT2", "COA3", "COA7", "COASY", "COLGALT1", "COMT", "COPA", "COPB2", "COQ8A", "COQ9", "COX2", "COX4I1", "COX5A", "CPOX", "CPSF1", "CPT1A", "CPT2", "CRK", "CRTAP", "CSDE1", "CSE1L", "CSNK2A2", "CSNK2B", "CSTB", "CTBP1", "CTCF", "CTNNB1", "CTNNBL1", "CTNND1", "CTSA", "CTSB", "CTSC", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CWC27", "CWF19L1", "CXorf56", "CYB5R3", "CYC1", "CYFIP2", "CYP51A1", "DAD1", "DAG1", "DARS", "DARS2", "DAXX", "DBN1", "DBT", "DCPS", "DCTN1", "DCUN1D1", "DDOST", "DDRGK1", "DDX10", "DDX3X", "DDX41", "DDX5", "DDX6", "DEGS1", "DEK", "DGKE", "DHCR24", "DHCR7", "DHFR", "DHPS", "DHX16", "DHX30", "DHX37", "DHX38", "DHX9", "DIABLO", "DIAPH1", "DIAPH2", "DIAPH3", "DIS3", "DKC1", "DLD", "DLG3", "DLST", "DNAAF5", "DNAJB1", "DNAJC13", "DNAJC19", "DNAJC2", "DNAJC3", "DNM1L", "DNM2", "DNMT1", "DOCK7", "DPAGT1", "DPM1", "DSC3", "DSG2", "DSP", "DST", "DYM", "DYNC1H1", "DYNC1I2", "EARS2", "ECE1", "ECHS1", "EDC3", "EEF1A2", "EEF2", "EFL1", "EFTUD2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B5", "EIF2S2", "EIF3E", "EIF3F", "EIF3H", "EIF4A2", "EIF4A3", "EIF4E", "EIF4G1", "EIF4H", "EIF5A", "ELAC2", "ELP1", "ELP2", "ELP3", "EMC1", "EMD", "EMG1", "EML4", "ENO1", "ENO2", "EPB41", "EPB41L3", "EPHA7", "EPHX1", "EPPK1", "EPRS", "ERAL1", "ERC1", "ERCC2", "ERCC3", "ERLIN1", "ERLIN2", "ETFA", "ETFB", "ETFDH", "ETNK1", "EWSR1", "EXOC6B", "EXOC8", "EXOSC2", "EXOSC3", "EXOSC9", "EZR", "FABP5", "FADS2", "FAF1", "FAH", "FAM3C", "FAM50A", "FANCD2", "FANCI", "FAR1", "FARS2", "FARSB", "FASN", "FASTKD2", "FDPS", "FDXR", "FECH", "FEN1", "FGFR1OP", "FH", "FHL1", "FIP1L1", "FKBP10", "FKBP14", "FKBP1A", "FKBP5", "FKBP8", "FLAD1", "FLNA", "FLNB", "FLNC", "FMR1", "FNTA", "FNTB", "FOXRED1", "FSCN1", "FTL", "FTO", "FUBP1", "FUCA1", "FUS", "G6PD", "GAA", "GAL", "GALK1", "GALNT2", "GANAB", "GAPDH", "GARS", "GART", "GATAD2B", "GBA", "GBE1", "GCDH", "GCLC", "GDAP1", "GDI1", "GEMIN4", "GFM1", "GFPT1", "GGCX", "GGPS1", "GIGYF2", "GLA", "GLB1", "GLDC", "GLMN", "GLO1", "GLS", "GLUD1", "GM2A", "GMPPB", "GMPS", "GNA13", "GNAI3", "GNPAT", "GNS", "GOLGA5", "GOPC", "GOT1", "GOT2", "GPAA1", "GPHN", "GPI", "GPT2", "GRB2", "GSR", "GSS", "GSTM3", "GTF2I", "GTPBP3", "GUF1", "GYG1", "GYS1", "H4C1*", "HADH", "HADHA", "HADHB", "HCCS", "HCFC1", "HDAC1", "HDAC2", "HELLS", "HEXA", "HEXB", "HIBCH", "HIKESHI", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HMBS", "HMGA1", "HMGB3", "HMGCL", "HMGCR", "HMMR", "HMOX1", "HNRNPA1", "HNRNPA2B1", "HNRNPDL", "HNRNPH2", "HNRNPK", "HNRNPU", "HPRT1", "HPS6", "HSD17B10", "HSD17B4", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA2", "HSPA4", "HSPA8", "HSPA9", "HSPB1", "HSPD1", "HSPE1", "HSPH1", "HTRA2", "HUWE1", "HYOU1", "IARS", "IARS2", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IFT27", "IGF2R", "IKBKG", "ILF3", "ILK", "IMPA1", "IMPAD1", "IMPDH1", "IMPDH2", "IPO7", "IRS4", "ITGB1", "ITPA", "IVD", "JAGN1", "JUP", "KARS", "KDM1A", "KDM3B", "KDSR", "KIF11", "KIF14", "KIF22", "KIF2A", "KIF2C", "KIF4A", "KIF5B", "KIFBP", "KLC2", "KMT2A", "KTN1", "L2HGDH", "LAMP2", "LARP7", "LARS", "LARS2", "LAS1L", "LASP1", "LBR", "LDHA", "LDHB", "LEMD2", "LEMD3", "LGALS3BP", "LGMN", "LIPA", "LMNA", "LMNB1", "LMNB2", "LNPK", "LONP1", "LRBA", "LRP1", "LRPPRC", "LSS", "LTA4H", "LZTFL1", "M6PR", "MACF1", "MAD2L1", "MAGED2", "MAGT1", "MAN2B1", "MAP1B", "MAP2K2", "MAP4", "MAPK1", "MAPK14", "MARS", "MASTL", "MATR3", "MBOAT7", "MCCC1", "MCCC2", "MCL1", "MCM2", "MCM3", "MCM5", "MCM7", "MCTS1", "MDC1", "MDH1", "MDH2", "MECP2", "MED23", "MED25", "METTL14", "MFN2", "MGME1", "MICU1", "MIF", "MIPEP", "MKI67", "MMAB", "MOGS", "MPDU1", "MPI", "MPV17", "MRE11", "MRPL12", "MRPL3", "MRPL44", "MRPS16", "MRPS22", "MRPS23", "MRPS34", "MRPS7", "MSH2", "MSH6", "MSI2", "MSMO1", "MSN", "MSTO1", "MTA1", "MTMR14", "MTMR2", "MTOR", "MTPAP", "MTR", "MUT", "MVK", "MYH10", "MYH9", "MYO6", "NAA15", "NAGA", "NAGLU", "NAMPT", "NANS", "NAXE", "NCAPD2", "NCAPD3", "NCAPG2", "NCAPH", "NCSTN", "ND1", "NDUFA11", "NDUFA13", "NDUFA4", "NDUFA9", "NDUFAF2", "NDUFAF3", "NDUFAF4", "NDUFB3", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS6", "NDUFS7", "NDUFS8", "NDUFV1", "NDUFV2", "NEFL", "NEK9", "NFU1", "NHP2", "NME1", "NNT", "NONO", "NOP56", "NPC1", "NPC2", "NPM1", "NSD2", "NSDHL", "NSMCE2", "NSUN2", "NSUN5", "NT5C2", "NTHL1", "NUBPL", "NUCB2", "NUDT1", "NUMA1", "NUP107", "NUP133", "NUP155", "NUP160", "NUP188", "NUP205", "NUP214", "NUP37", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NXN", "OAT", "OCLN", "OCRL", "OGDH", "OGT", "OPA1", "OPA3", "OSGEP", "OXCT1", "P3H1", "P4HB", "PABPC1", "PABPN1", "PAF1", "PAFAH1B1", "PAFAH1B2", "PARK7", "PARN", "PARP1", "PBRM1", "PC", "PCBD1", "PCBP1", "PCCA", "PCCB", "PCM1", "PCNA", "PDAP1", "PDE6D", "PDHA1", "PDHB", "PDK3", "PDXK", "PEPD", "PEX14", "PEX16", "PEX19", "PEX5", "PFKM", "PFN1", "PGK1", "PGM1", "PGM3", "PHB", "PHF6", "PHGDH", "PHIP", "PHKA1", "PIBF1", "PICALM", "PIGK", "PIGS", "PIGT", "PIGU", "PINX1", "PISD", "PKM", "PLAA", "PLCG1", "PLD3", "PLEC", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLPBP", "PLS3", "PMPCA", "PMPCB", "PMVK", "PNKP", "PNN", "PNP", "PNPLA6", "PNPT1", "POGZ", "POLA1", "POLD1", "POLE", "POLE3", "POLE4", "POLR1A", "POLR1B", "POLR1C", "POLR3A", "POP1", "POR", "PPA2", "PPIB", "PPIF", "PPOX", "PPP1CB", "PPP1R12A", "PPP2R1A", "PPP2R5D", "PPP3CA", "PPP5C", "PPP6C", "PPT1", "PRC1", "PRCC", "PRDX2", "PRDX4", "PRDX5", "PREPL", "PRKAA2", "PRKACA", "PRKAG1", "PRKAR1A", "PRKCB", "PRKCSH", "PRKDC", "PRKRA", "PRPF31", "PRPF4", "PRPF6", "PRPF8", "PSAP", "PSAT1", "PSIP1", "PSMB1", "PSMB2", "PSMB4", "PSMB5", "PSMD12", "PSMD4", "PTDSS1", "PTPN11", "PTRH2", "PUF60", "PUM1", "PURA", "PUS7", "PYCR1", "PYCR2", "PYGL", "QARS", "QKI", "QRSL1", "RAB10", "RAB18", "RAB3GAP2", "RAB7A", "RAB8A", "RABEP1", "RAC1", "RAD21", "RAD23A", "RAD23B", "RANBP2", "RANBP3", "RAPGEF2", "RARS", "RARS2", "RBM10", "RBM12", "RBM28", "RBM6", "RBMX", "RDH11", "RDX", "RFC1", "RFC2", "RFT1", "RHEB", "RINT1", "RMC1", "RMND1", "RNASEH2A", "RNASET2", "ROCK1", "RPA2", "RPL10", "RPL11", "RPL13", "RPL15", "RPL18", "RPL21", "RPL22", "RPL26", "RPL27", "RPL3", "RPL35", "RPL35A", "RPL5", "RPN1", "RPS10", "RPS15A", "RPS17", "RPS19", "RPS2", "RPS23", "RPS24", "RPS28", "RPS29", "RPS3", "RPS6KA1", "RPS6KA3", "RPS7", "RPSA", "RRM1", "RRM2", "RSPRY1", "RTN2", "RTN4IP1", "SAMHD1", "SARS", "SART1", "SBDS", "SCARB2", "SCO1", "SCO2", "SCRIB", "SDHA", "SDHB", "SEC23A", "SEC23B", "SEC24D", "SEC31A", "SEC61A1", "SEC63", "SEPT2", "SEPT9", "SERPINB6", "SERPINH1", "SET", "SF3B1", "SFPQ", "SFXN4", "SGPL1", "SH3GL1", "SIGMAR1", "SIN3A", "SKIV2L", "SKP2", "SLC16A1", "SLC19A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A19", "SLC25A20", "SLC25A21", "SLC25A22", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A4", "SLC25A42", "SLC25A5", "SLC25A6", "SLC27A4", "SLC33A1", "SLC39A14", "SLC3A2", "SLC9A3R1", "SMARCA4", "SMARCAD1", "SMARCB1", "SMARCC2", "SMARCD1", "SMARCE1", "SMC1A", "SMC3", "SMN1*", "SMPD4", "SMS", "SMYD3", "SND1", "SNRNP200", "SNRPE", "SNX3", "SOAT1", "SOD2", "SON", "SORD", "SPART", "SPATA5", "SPECC1L", "SPEN", "SPR", "SPTAN1", "SPTBN2", "SPTLC1", "SPTLC2", "SQLE", "SQSTM1", "SRP54", "SRP72", "SRSF3", "SSB", "SSR4", "STAG1", "STAG2", "STAMBP", "STARD3", "STAT1", "STAT3", "STIM1", "STMN1", "STRAP", "STRN", "STT3A", "STT3B", "STX5", "SUCLA2", "SUCLG1", "SUZ12", "SV2A", "SYNE2", "TAF15", "TALDO1", "TAP1", "TARDBP", "TARS", "TARS2", "TBC1D4", "TBCD", "TBCE", "TBL2", "TCEA1", "TCOF1", "TECR", "TELO2", "TFAM", "TFG", "TFRC", "THOC2", "THOC6", "TIA1", "TIMM17A", "TIMM50", "TK1", "TKT", "TMCO1", "TMEM126B", "TMEM165", "TMEM199", "TMEM230", "TMEM38B", "TMEM43", "TMF1", "TMTC3", "TMX2", "TNPO3", "TOE1", "TOP1", "TOP2A", "TOP2B", "TOR1AIP1", "TP53", "TPD52", "TPI1", "TPM1", "TPM3", "TPM4", "TPP1", "TPR", "TPX2", "TRAF2", "TRIM25", "TRIM33", "TRIP12", "TRIP13", "TRMT10C", "TRMU", "TRRAP", "TSFM", "TSG101", "TTC19", "TUBB", "TUBB2A", "TUBB2B", "TUBB3", "TUBB4B", "TUBB6", "TUBGCP2", "TUBGCP4", "TUFM", "TWF1", "TWNK", "TXLNA", "TXNRD1", "TYMS", "U2AF1", "UBA1", "UBE2N", "UBE3A", "UBQLN2", "UBQLN4", "UBR5", "UBTF", "UFC1", "UFM1", "UGCG", "UGP2", "UMPS", "UNC119", "UNG", "UQCC2", "UQCRB", "UQCRC2", "UQCRQ", "UROD", "USP9X", "UTP4", "VANGL1", "VAPB", "VARS1", "VCL", "VCP", "VIM", "VKORC1L1", "VPS13A", "VPS13D", "VPS16", "VPS33A", "VPS33B", "VPS35", "VPS4A", "VPS51", "VPS53", "VRK1", "WARS", "WASHC5", "WBP2", "WDR1", "WDR11", "WDR26", "WDR34", "WDR36", "WDR5", "WFS1", "WIPI2", "XPNPEP3", "XPO1", "XRCC1", "XRCC5", "XRCC6", "YARS", "YARS2", "YBX1", "YME1L1", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAZ", "ZC3H14", "ZMPSTE24", "ZMYM2"], "leading_proteins": ["AARS2", "ABCC1", "ACOX1", "AGK", "AGPS", "AIFM1", "AIP", "ALG1", "ALG12", "ANKLE2", "ANO10", "ARL6IP1", "ASAH1", "ATP1A1", "ATP2A2", "ATP6", "ATP6AP1", "B4GAT1", "BRAT1", "C19orf70", "C1QBP", "CERS1", "CLCC1", "CLN5", "CLPP", "CNOT1", "COA3", "COMT", "COQ9", "COX2", "COX4I1", "CPT2", "CRTAP", "CYC1", "CYP51A1", "DEGS1", "DHFR", "DIABLO", "DNAJC19", "DPAGT1", "ECE1", "EMD", "ERLIN1", "FARSB", "FASN", "FKBP10", "FKBP14", "FKBP1A", "FNTA", "FOXRED1", "FUS", "GAA", "GAL", "GBA", "GGCX", "GLB1", "GM2A", "HEXA", "HTRA2", "MAGT1", "MED25", "MIPEP", "MSMO1", "NAGA", "NAGLU", "ND1", "NDUFA11", "NDUFA13", "NDUFB3", "NDUFB9", "NFU1", "NNT", "OPA1", "OPA3", "PEX14", "PEX16", "PEX19", "PEX5", "PIGK", "PIGU", "PISD", "PLD3", "PMPCA", "PNPLA6", "PPT1", "PRKAR1A", "PRKRA", "PSAP", "PSMB2", "RAB10", "RFT1", 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a/protein_atlas_molecular_function/df_merge.tsv b/protein_atlas_molecular_function/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..59a2f26b09eff08f8c8363f0a625ac66e620689f --- /dev/null +++ b/protein_atlas_molecular_function/df_merge.tsv @@ -0,0 +1,5 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Receptor 11 36 3.1452433875329744 0.0016594870779642 13.475728155339803 38.71116504854369 1.6655960679271569 0.1791616261110447 5.431559450288914 6.105192092581698 1.9169648296245776 0.2753083483896962 0.3648431222141075 0.1182182962859897 0.2144950360506774 0.0744707897775741 0.4053034107033972 +Translocase 12 22 2.5513368271272805 0.0107310560323399 8.031553398058252 23.23543689320388 0.8266305625937611 0.3429767730570308 3.903132239147793 3.2553774114037415 1.2917497354360188 0.3272657999875639 0.0003659277272577 1.0 0.4374181157102795 0.0537446424289807 0.0004619557442503 +Glycosidase 7 19 2.299562908843993 0.0214729954893193 7.798543689320389 18.135922330097088 0.5112745472223946 0.1951515073440806 2.9064203812520417 1.9684331341643595 1.9501681029822375 0.2619382904734375 0.0006601421792455 0.187449079081247 0.3376050929703735 0.6447958176859679 0.0008009677844218 +Glycosyltransferase 11 34 2.182255963324806 0.02909064709417 8.383495145631068 33.63106796116505 0.9005425082235603 0.4380439374186179 3.633517034002208 4.6602851932859135 0.9766631781348049 0.3531801259598526 0.0085065926406853 0.1115719060554689 0.104205851680364 0.0020648618831818 0.0106034028476711 diff --git a/protein_atlas_molecular_function/metrics.json b/protein_atlas_molecular_function/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..2f03c1c4b9cd5a8b005c4163ff2093d37a77a1f9 --- /dev/null +++ b/protein_atlas_molecular_function/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2974, + "annotations_size": 97, + "title": "Average number of proteins per term", + "value": 35.371134020618555 +} \ No newline at end of file diff --git a/protein_atlas_molecular_function/paths.json b/protein_atlas_molecular_function/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..7406204526ffc81e065c6dc7705a333649a32035 --- /dev/null +++ b/protein_atlas_molecular_function/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/protein_atlas_molecular_function/fragment/C220/C220_val_log2fc"} \ No newline at end of file diff --git a/protein_atlas_molecular_function/result.tsv b/protein_atlas_molecular_function/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..f657880bf663f65e222d0000e32b3b16c47d0eec --- /dev/null +++ b/protein_atlas_molecular_function/result.tsv @@ -0,0 +1,24 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Receptor 0.5878386110071544 3.1452433875329744 0.0016594870779642 0.1487964233685424 0.0370540178801669 36 Q9NS69,Q9Y5M8,P24390,O15173,O15118,Q14108,Q8WU17,P35613,Q14739,O00264,Q8WTV0 11 +Translocase 0.5754868396111364 2.5513368271272805 0.0107310560323399 0.6488485826055924 0.0743508882240695 22 P08183,P20020,Q9HD20,P16615,P08574,P35670,P00403,P05023,Q13423,Q03518,P03886,P33527 12 +Glycosidase 0.5664938512852926 2.299562908843993 0.0214729954893193 0.8782236096782449 0.1301800351539986 19 P17050,P04062,P54802,P06280,P10253,Q9BTY2,P16278 7 +Glycosyltransferase 0.4809326505816916 2.182255963324806 0.02909064709417 0.9429399144383284 0.1659878098902646 34 P46977,P04062,Q8N4A0,Q9H3H5,P43490,Q10472,Q9BV10,Q13126,Q9BT22,Q16739,O43505 11 +Porin 0.862289562289575 1.966231617392919 0.0492718618059306 0.992561836418661 0.2515458207986987 4 P45880,P21796,Q9Y277 3 +Carboxypeptidase 0.7377926708078316 1.9245429713013924 0.0542865598634134 0.9955467463940264 0.2589171588386265 6 Q9HB40,P42785,P10619 3 +Host cell receptor for virus entry 0.5801323354134232 1.9106137949253656 0.0560542302640325 0.996285816815752 0.2589171588386265 14 P11279,O15118,Q14108,P35613,P02786,Q8WTV0 6 +Ion channel 0.607115666006545 1.6784611881967144 0.0932571011540535 0.9999248439719692 0.3607564959624389 10 Q9BVC6,Q9UM00,Q4KMQ2,Q9C0H2,Q96S66 5 +Monooxygenase 0.885560417367885 1.4438279440690909 0.1487873794382013 0.9999998364346726 0.4722073393051238 3 Q16850,Q6UW02 2 +Acyltransferase 0.3984441455278849 1.4194092377026646 0.1557797408016903 0.9999999265131412 0.4722073393051238 36 O15269,Q9NUQ2,Q8IUH4,Q8NF37,P23786,Q9BWD1,Q96N66 7 +Chloride channel 0.6724238088613614 1.3989763238759458 0.1618200830441525 0.9999999633804226 0.4756529713722058 5 Q9C0H2,Q4KMQ2 2 +Rotamase 0.4000917345349752 1.1525161444327043 0.2491090394740809 0.999999999999147 0.4884966249788943 22 Q96AY3,Q9Y680,Q9NWM8,O95302 4 +Serine protease 0.5347434140394212 1.1302115598750695 0.2583870899174894 0.9999999999997446 0.4884966249788943 9 O43464,O14773,Q16740,Q4J6C6 4 +Prenyltransferase 0.7806191117092982 1.0357370664726298 0.3003248248170516 0.9999999999999992 0.4937543730043052 2 P49354 1 +Lyase 0.318141872231404 0.6338749609065064 0.5261624276177779 1.0 0.6609189490839852 41 Q99735,Q6Y1H2,O95470,O14880,P12956,P49327,A1L0T0,P22830,P53701,P38435,Q9P035,Q9UG56 12 +Metalloprotease 0.3294868121736694 0.6036185962971233 0.5460972462262617 1.0 0.6702196361480932 26 Q9NZ08,P42892,Q5JRX3,P55786,Q9UIQ6,O75844,Q99797,Q9BYT8 8 +Cytokine 0.5443701315845599 0.5936317166610011 0.552758462802551 1.0 0.6702196361480932 4 P43490 1 +Threonine protease 0.657691013126875 0.5649366825465187 0.5721168319555527 1.0 0.6761456398889996 3 P28072,P28074 2 +Oxidoreductase 0.3289789118236869 0.399523214560915 0.6895077219359753 1.0 0.7687614830780414 155 Q8NBX0,P13073,Q8N0U8,P09622,Q15800,Q53GQ0,O95864,P30519,Q9NZ01,Q96LJ7,Q16836,Q9H9P8,O95825,Q99735,O95831,P16435,P11177,Q14534,Q14739,Q16850,Q9UBM7,Q15392,Q96CU9,O00767,Q8NBQ5,Q6NUM9,Q9UHG3,O15254,O95881,Q8N4Q0,P40939,P35270,P49327,P51649,Q6UW02,Q9BU89,P21912,Q9BY49,P51648,Q8NBN7,O14880,Q8NB78,O15121,P09601,Q15067,Q06136,Q9Y394,P13674,P00374 49 +Guanine-nucleotide releasing factor 0.3514560419629333 0.3674394226817651 0.7132912699255747 1.0 0.7700553376811449 13 Q02818,P80303 2 +Voltage-gated channel 0.4362979951279749 0.3323194836775155 0.7396480292609402 1.0 0.788416031190233 5 Q9BVC6,Q4KMQ2 2 +Serine protease inhibitor 0.4562137085934413 0.2706827687569374 0.786635030763803 1.0 0.8204687955278376 4 Q06481,P05067 2 +Protease 0.2584493127829169 0.2071836874982924 0.8358664064154828 1.0 0.8534635939189668 77 P42785,Q5JRX3,Q99538,Q16740,O43464,P36776,Q96RU2,P07858,Q9UIQ6,Q9HB40,Q92643,Q9BYT8,P42892,O14773,P55786,Q15005,O75844,Q9H3G5,Q9NZ08,P10619,P28072,P28074,P67812,Q99797,Q4J6C6 25 diff --git a/protein_atlas_molecular_function/selections.json b/protein_atlas_molecular_function/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..4bb13d4e0690cbfd7fba0e72d91a43dcf2e46bc3 --- /dev/null +++ b/protein_atlas_molecular_function/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["Actin capping", "Actin-binding", "Activator", "Acyltransferase", "Allosteric enzyme", "Aminoacyl-tRNA synthetase", "Aminopeptidase", "Aminotransferase", "Antibiotic", "Antimicrobial", "Antioxidant", "Aspartyl protease", "Blood group antigen", "Calcium channel", "Calmodulin-binding", "Carboxypeptidase", "Chaperone", "Chloride channel", "Chromatin regulator", "Cyclin", "Cytokine", "DNA-binding", "DNA-directed DNA polymerase", "Decarboxylase", "Developmental protein", "Dioxygenase", "Dipeptidase", "Elongation factor", "Endonuclease", "Excision nuclease", "Exonuclease", "Fungicide", "GTPase activation", "Glycosidase", "Glycosyltransferase", "Growth factor", "Guanine-nucleotide releasing factor", "Helicase", "Heparin-binding", "Hormone", "Host cell receptor for virus entry", "Hydrolase", "IgG-binding protein", "Initiation factor", "Integrin", "Ion channel", "Isomerase", "Kinase", "Ligase", "Lyase", "Metalloenzyme inhibitor", "Metalloprotease", "Methyltransferase", "Mitogen", "Monooxygenase", "Motor protein", "Multifunctional enzyme", "Muscle protein", "Myosin", "Neuropeptide", "Nuclease", "Nucleotidyltransferase", "Oxidoreductase", "Peroxidase", "Phospholipase A2 inhibitor", "Porin", "Potassium channel", "Prenyltransferase", "Protease", "Protease inhibitor", "Protein phosphatase", "Protein phosphatase inhibitor", "Protein synthesis inhibitor", "RNA-binding", "Receptor", "Repressor", "Ribonucleoprotein", "Ribosomal protein", "Rotamase", "Serine esterase", "Serine protease", "Serine protease inhibitor", "Serine/threonine-protein kinase", "Signal transduction inhibitor", "Thiol protease", "Thiol protease inhibitor", "Threonine protease", "Topoisomerase", "Transducer", "Transferase", "Translational shunt", "Translocase", "Tumor antigen", "Tyrosine-protein kinase", "Voltage-gated channel", "rRNA-binding", "tRNA-binding"], "available_proteins": ["AAMP", "AARS", "AARS2", "AASDHPPT", "AASS", "ABCB1", "ABCC1", "ABCE1", "ABCF1", "ABHD10", "ABHD12", "ABHD14B", "ABHD6", "ACAA2", "ACACA", "ACACB", "ACAD11", "ACAD9", "ACADM", "ACADVL", "ACAT1", "ACAT2", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT9", "ACOX1", "ACOX3", "ACP1", "ACP2", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN4", "ACTR2", "ACTR3", "ADAR", "ADD1", "ADD3", "ADH5", "ADI1", "ADNP", "ADPGK", "ADPRHL2", "ADSL", "ADSS", "AFG3L2", "AGK", "AGL", "AGPAT1", "AGPAT5", "AGPS", "AHCY", "AHCYL1", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AK1", "AK2", "AKAP12", "AKAP13", "AKAP8", "AKR1A1", "AKR1B1", "AKR7A2", "AKT2", "ALDH18A1", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALG1", "ALG11", "ALG12", "ALKBH5", "ANKHD1", "ANKRD17", "ANO6", "ANP32B", "ANP32E", "ANXA1", "ANXA2", "ANXA3", "APEH", "APEX1", "APLP2", "APP", "APRT", "AQR", "ARAF", "ARFGAP1", "ARFGAP2", "ARHGAP1", "ARHGAP17", "ARHGDIA", "ARHGEF1", "ARHGEF2", "ARID1A", "ARID3B", "ARIH1", "ARIH2", "ARMT1", "ARPC1A", "ARPC2", "ARPC3", "ARPC4", "ARPC5", "ASAH1", "ASCC3", "ASNA1", "ASNS", "ASPH", "ATAD1", "ATAD2", "ATE1", "ATG3", "ATG4B", "ATIC", "ATL2", "ATP13A1", "ATP1A1", "ATP2A2", "ATP2B1", "ATP5B", "ATP6AP2", "ATP6V1A", "ATP6V1B2", "ATP6V1E1", "ATP7B", "AURKA", "AURKB", "B3GALT6", "B4GAT1", "BABAM1", "BAG2", "BAG4", "BAG5", "BAG6", "BANF1", "BANP", "BAZ1B", "BCLAF1", "BCS1L", "BIRC6", "BLMH", "BLVRA", "BPHL", "BPNT1", "BRAP", "BRD2", "BSG", "BTAF1", "BTF3", "BUB1B", "BUD23", "BZW1", "BZW2", "CAD", "CALD1", "CALR", "CAMK1", "CAMK2G", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPRIN1", "CAPZA1", "CAPZA2", "CAPZB", "CARM1", "CARS", "CARS2", "CASK", "CAST", "CBR1", "CBX3", "CBX8", "CCAR1", "CCAR2", "CCDC47", "CCNB1", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD320", "CDC34", "CDC37", "CDC42", "CDC5L", "CDC7", "CDIPT", "CDK1", "CDK2", "CDK4", "CDK5", "CDK6", "CDKAL1", "CDS2", "CEBPZ", "CECR2", "CELF2", "CEP290", "CEP55", "CERS1", "CERS2", "CFL1", "CFL2", "CHAC2", "CHAF1A", "CHCHD3", "CHD1", "CHD1L", "CHD4", "CHKA", "CHMP1A", "CHORDC1", "CHRAC1", "CHST14", "CHTF18", "CIRBP", "CKB", "CKMT1A*", "CLCC1", "CLGN", "CLIC1", "CLIC4", "CLPB", "CLPP", "CLPTM1", "CLPX", "CLU", "CLUH", "CMAS", "CMPK1", "CMTR1", "CNDP2", "CNN3", "CNOT1", "CNOT2", "CNOT9", "CNP", "COASY", "COLEC12", "COLGALT1", "COMT", "COPA", "COPS5", "COQ8A", "CORO1B", "CORO1C", "CORO7", "COTL1", "COX2", "COX4I1", "CPD", "CPNE1", "CPOX", "CPSF1", "CPSF2", "CPSF3", "CPSF6", "CPSF7", "CPT1A", "CPT2", "CPVL", "CROT", "CRYZL1", "CS", "CSDE1", "CSK", "CSNK1A1", "CSNK2A2", "CSRP2", "CSTB", "CSTF2", "CTBP1", "CTBP2", "CTCF", "CTDSPL2", "CTNNB1", "CTPS1", "CTPS2", "CTSA", "CTSB", "CTSC", "CUL5", "CXorf57", "CYB5R1", "CYB5R3", "CYC1", "CYFIP1", "CYP20A1", "CYP51A1", "DAG1", "DAP3", "DARS", "DARS2", "DAXX", "DAZAP1", "DBN1", "DBNL", "DBT", "DCAF13", "DCAF7", "DCD", "DCP1B", "DCPS", "DCTD", "DCTPP1", "DCXR", "DDAH2", "DDB1", "DDI2", "DDT", "DDX1", "DDX10", "DDX17", "DDX18", "DDX20", "DDX21", "DDX23", "DDX24", "DDX28", "DDX39A", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX50", "DDX51", "DDX52", "DDX54", "DDX55", "DDX56", "DDX6", "DEGS1", "DEK", "DENR", "DGKE", "DHCR24", "DHCR7", "DHFR", "DHPS", "DHRS1", "DHRS4", "DHRS7", "DHRS7B", "DHX15", "DHX16", "DHX29", "DHX30", "DHX36", "DHX37", "DHX38", "DHX40", "DHX57", "DHX8", "DHX9", "DIAPH1", "DIAPH2", "DIMT1", "DIS3", "DKC1", "DLAT", "DLD", "DLST", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC13", "DNAJC19", "DNAJC2", "DNAJC3", "DNAJC7", "DNAJC8", "DNAJC9", "DNM1L", "DNM2", "DNMT1", "DNPH1", "DOCK7", "DOHH", "DOLPP1", "DPAGT1", "DPH2", "DPH5", "DPM1", "DPP3", "DPP9", "DPYSL2", "DRG1", "DRG2", "DST", "DSTN", "DTYMK", "DUSP12", "DUSP3", "DUSP9", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNC1LI2", "DYNLL2", "EARS2", "ECD", "ECE1", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "EDC3", "EDF1", "EDRF1", "EEF1A2", "EEF1B2", "EEF1D", "EEF1G", "EEF2", "EFL1", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B5", "EIF2D", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAC2", "ELAVL1", "ELMOD2", "ELP3", "EMD", "EMG1", "ENAH", "ENDOD1", "ENO1", "ENO2", "ENOPH1", "EPB41", "EPB41L2", "EPB41L3", "EPHA7", "EPHX1", "EPHX2", "EPRS", "ERAL1", "ERAP1", "ERCC2", "ERCC3", "ERCC6L", "ERMP1", "ERO1A", "ERP44", "ESD", "ESPL1", "ETFDH", "ETNK1", "EWSR1", "EXO1", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC9", "F11R", "FADS2", "FAH", "FAHD1", "FAM208A", "FAM213A", "FAM3C", "FANCI", "FAR1", "FARP1", "FARS2", "FARSA", "FARSB", "FASN", "FASTKD2", "FBL", "FCGRT", "FDFT1", "FDPS", "FDXR", "FECH", "FEN1", "FH", "FHL1", "FHOD1", "FIP1L1", "FKBP10", "FKBP14", "FKBP1A", "FKBP2", "FKBP3", "FKBP4", "FKBP5", "FKBP7", "FKBP8", "FKBP9", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FMR1", "FN3KRP", "FNTA", "FNTB", "FOXRED1", "FSCN1", "FTO", "FTSJ3", "FUBP1", "FUBP3", "FUCA1", "FUCA2", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GADD45GIP1", "GAK", "GAL", "GALK1", "GALNT1", "GALNT2", "GALNT4", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GATAD2B", "GBA", "GBE1", "GBF1", "GCAT", "GCDH", "GCLC", "GCN1", "GDI1", "GDI2", "GDPD1", "GEMIN5", "GFM1", "GFPT1", "GGCT", "GGCX", "GGH", "GGPS1", "GLA", "GLB1", "GLDC", "GLO1", "GLS", "GLT8D1", "GLUD1", "GLYR1", "GM2A", "GMFB", "GMPPB", "GMPS", "GNA13", "GNAI2", "GNAI3", "GNG12", "GNPAT", "GNPDA1", "GNS", "GOT1", "GOT2", "GPAM", "GPAT4", "GPD2", "GPHN", "GPI", "GPKOW", "GPR89B", "GPT2", "GRHPR", "GRPEL1", "GRSF1", "GSR", "GSS", "GSTK1", "GSTM3", "GSTO1", "GTF2B", "GTF2F1", "GTF2I", "GTF3C1", "GTF3C3", "GUF1", "GYG1", "GYS1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACD2", "HACD3", "HACL1", "HADH", "HADHA", "HADHB", "HAT1", "HBS1L", "HCCS", "HCFC1", "HDAC1", "HDAC2", "HDGF", "HDLBP", "HEATR1", "HECTD1", "HELLS", "HEXA", "HEXB", "HIBADH", "HIBCH", "HINT2", "HINT3", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLTF", "HM13", "HMBS", "HMCES", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMGCL", "HMGCR", "HMGCS1", "HMGN2", "HMOX1", "HMOX2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPLL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HP1BP3", "HPRT1", "HS2ST1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA14", "HSPA1B", "HSPA2", "HSPA4L", "HSPA8", "HSPA9", "HSPB1", "HSPD1", "HSPE1", "HTATSF1", "HTRA2", "HUWE1", "HYOU1", "IARS", "IARS2", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDI1", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "ILF2", "ILF3", "ILK", "ILKAP", "ILVBL", "IMP3", "IMP4", "IMPA1", "IMPAD1", "IMPDH1", "IMPDH2", "INA", "INTS11", "IQGAP1", "IQGAP2", "IRS4", "ITCH", "ITGB1", "ITPA", "IVD", "KARS", "KAT7", "KDELC2", "KDELR1", "KDM1A", "KDM1B", "KDM2A", "KDM3B", "KDSR", "KHDRBS1", "KHSRP", "KIAA0391", "KIAA1147", "KIF11", "KIF14", "KIF15", "KIF18B", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF4A", "KIF5B", "KIFBP", "KIFC1", "KIN", "KLC1", "KLC2", "KLC4", "KMT2A", "KRR1", "L2HGDH", "LAMP1", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LASP1", "LBR", "LDAH", "LDHA", "LDHB", "LEMD3", "LGMN", "LIG1", "LIG3", "LIMA1", "LIPA", "LNPEP", "LNPK", "LONP1", "LPCAT1", "LPCAT3", "LPGAT1", "LRP1", "LRPAP1", "LRPPRC", "LRWD1", "LSM2", "LSM3", "LSM4", "LSM6", "LSM7", "LSS", "LTA4H", "LYAR", "LYPLA1", "M6PR", "MACF1", "MAGED2", "MAN1A1", "MAN2A1", "MAN2B1", "MANF", "MAP1S", "MAP2K2", "MAPK1", "MAPK14", "MARC1", "MARCH5", "MARS", "MASTL", "MAT2A", "MATR3", "MBD3", "MBOAT7", "MCAT", "MCCC1", "MCCC2", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCTS1", "MCU", "MDH1", "MDH2", "MDN1", "ME1", "ME2", "MECP2", "MED21", "MED23", "MED24", "MED25", "MEPCE", "METAP2", "METTL13", "METTL14", "METTL3", "METTL7A", "METTL7B", "METTL9", "MFN1", "MFN2", "MGEA5", "MGME1", "MGST2", "MGST3", "MIF", "MINDY3", "MIPEP", "MKI67", "MKRN2", "MMAB", "MMS19", "MOGS", "MORF4L1", "MOV10", "MPG", "MPHOSPH10", "MPI", "MPRIP", "MPST", "MRC2", "MRE11", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL14", "MRPL15", "MRPL17", "MRPL19", "MRPL21", "MRPL22", "MRPL23", "MRPL24", "MRPL28", "MRPL3", "MRPL37", "MRPL38", "MRPL39", "MRPL40", "MRPL44", "MRPL46", "MRPL50", "MRPL53", "MRPL55", "MRPL58", "MRPL9", "MRPS11", "MRPS15", "MRPS16", "MRPS18A", "MRPS22", "MRPS23", "MRPS25", "MRPS27", "MRPS30", "MRPS31", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRPS9", "MSH2", "MSH3", "MSH6", "MSI2", "MSMO1", "MTA1", "MTA2", "MTAP", "MTHFD1L", "MTHFD2", "MTMR14", "MTMR2", "MTOR", "MTPAP", "MTR", "MUT", "MVK", "MYBBP1A", "MYG1", "MYH10", "MYH9", "MYL6", "MYO1B", "MYO1C", "MYO1D", "MYO6", "NAA15", "NAA40", "NAA50", "NADK2", "NAF1", "NAGA", "NAGLU", "NAMPT", "NANS", "NAP1L4", "NARS", "NAT10", "NAXE", "NCBP3", "NCL", "ND1", "NDUFAF2", "NDUFAF4", "NDUFAF7", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS7", "NDUFS8", "NDUFV1", "NDUFV2", "NEK9", "NELFCD", "NELFE", "NES", "NGDN", "NHP2", "NIFK", "NIP7", "NKRF", "NKTR", "NLN", "NME1", "NMT1", "NNT", "NOB1", "NOC2L", "NOL11", "NOL6", "NOL8", "NOL9", "NONO", "NOP2", "NOP56", "NOP58", "NOP9", "NOSIP", "NPC1", "NPEPPS", "NPLOC4", "NPM1", "NRDC", "NSA2", "NSD2", "NSDHL", "NSF", "NSMCE2", "NSUN2", "NSUN5", "NT5C2", "NT5C3B", "NT5DC1", "NT5DC2", "NTHL1", "NTMT1", "NTPCR", "NUCB1", "NUCB2", "NUDCD1", "NUDT1", "NUDT16L1", "NUDT21", "NUDT5", "NUDT9", "NUFIP2", "NUP153", "NUP98", "NXF1", "NXN", "OAT", "OCRL", "OGDH", "OGT", "OLA1", "OPA1", "OSGEP", "OTUB1", "OTUD4", "OTUD7B", "OXCT1", "OXSR1", "P3H1", "P4HA1", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PAFAH1B1", "PAFAH1B2", "PAFAH1B3", "PAICS", "PAK1IP1", "PAK2", "PALLD", "PANK4", "PAPOLA", "PARG", "PARK7", "PARN", "PARP1", "PATL1", "PBK", "PBRM1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCK2", "PCMT1", "PCNA", "PCYOX1", "PDCL3", "PDE12", "PDHA1", "PDHB", "PDIA3", "PDIA4", "PDIA5", "PDIA6", "PDK3", "PDLIM7", "PDXDC1", "PDXK", "PEBP1", "PECR", "PELO", "PELP1", "PEPD", "PFAS", "PFDN2", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGM3", "PGP", "PGRMC1", "PGRMC2", "PHAX", "PHB2", "PHC2", "PHF5A", "PHF6", "PHGDH", "PHKA1", "PI4K2A", "PI4KB", "PIGK", "PIK3R4", "PIN4", "PIP4K2C", "PIR", "PISD", "PITHD1", "PITRM1", "PKM", "PKMYT1", "PKN1", "PKN2", "PLA2G15", "PLAA", "PLBD2", "PLCG1", "PLD3", "PLD6", "PLEC", "PLK1", "PLOD1", "PLOD2", "PLS3", "PMF1", "PMPCB", "PMVK", "PNKP", "PNN", "PNO1", "PNP", "PNPLA6", "PNPT1", "POFUT1", "POGZ", "POLA1", "POLD1", "POLDIP3", "POLE", "POLE3", "POLE4", "POLR1A", "POLR1B", "POLR2B", "POLR2G", "POLR3A", "POLR3C", "POLRMT", "PON2", "POP1", "POR", "PPA1", "PPA2", "PPAT", "PPIB", "PPIC", "PPID", "PPIF", "PPIH", "PPIL1", "PPIL3", "PPIL4", "PPM1G", "PPME1", "PPOX", "PPP1CA", "PPP1CB", "PPP1R10", "PPP1R8", "PPP3CA", "PPP4C", "PPP5C", "PPP6C", "PPT1", "PPT2", "PPWD1", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PREP", "PREPL", "PRIM1", "PRIM2", "PRKAA2", "PRKACA", "PRKCB", "PRKDC", "PRKRA", "PRMT1", "PRMT3", "PRMT5", "PRMT9", "PRPF19", "PRPF31", "PRPF4B", "PRPF8", "PSAT1", "PSIP1", "PSMB5", "PSMB6", "PSMB7", "PSMD10", "PSMD14", "PSMD9", "PSME4", "PSMG1", "PSPC1", "PTBP1", "PTCD3", "PTDSS1", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK7", "PTPA", "PTPMT1", "PTPN1", "PTPN11", "PTPRF", "PTRH2", "PUDP", "PUF60", "PUM1", "PUM3", "PURA", "PUS7", "PYCR1", "PYCR2", "PYCR3", "PYGB", "PYGL", "QARS", "QKI", "QRSL1", "QSOX2", "RAB10", "RAB18", "RAB1A", "RAB1B", "RAB3GAP1", "RAB3GAP2", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RABGAP1", "RAC1", "RACGAP1", "RACK1", "RAD21", "RAD50", "RALA", "RALY", "RANBP1", "RANBP2", "RANGAP1", "RAP2B", "RAPGEF2", "RARS", "RARS2", "RAVER1", "RBBP5", "RBBP6", "RBBP7", "RBM10", "RBM12", "RBM14", "RBM17", "RBM19", "RBM22", "RBM25", "RBM26", "RBM27", "RBM28", "RBM34", "RBM39", "RBM4", "RBM5", "RBM6", "RBM8A", "RBMX", "RCC1", "RCC2", "RDH11", "RDH13", "RDH14", "RDX", "RECQL", "RETSAT", "REXO4", "RFC1", "RFC3", "RHOT1", "RHOT2", "RIDA", "RNASEH2A", "RNASET2", "RNF139", "RNF14", "RNF20", "RNF219", "RNF40", "RNPEP", "ROCK1", "RPA1", "RPA2", "RPAP1", "RPF1", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPP30", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS28", "RPS29", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RPUSD3", "RRM1", "RRM2", "RRP1B", "RRP8", "RRP9", "RTCB", "RTRAF", "RUVBL1", "RUVBL2", "SACM1L", "SAE1", "SAFB", "SAFB2", "SAMD4B", "SAMHD1", "SAP18", "SARM1", "SARNP", "SARS", "SARS2", "SART3", "SCAF1", "SCAF4", "SCARB1", "SCARB2", "SCCPDH", "SCD", "SCML2", "SCO1", "SCO2", "SCP2", "SCPEP1", "SCRIB", "SDHA", "SDHB", "SDR39U1", "SEC11A", "SEC61A1", "SEC63", "SENP3", "SEPHS1", "SERBP1", "SERPINB6", "SERPINH1", "SET", "SF1", "SF3B1", "SF3B4", "SF3B6", "SFPQ", "SGPL1", "SGTA", "SHMT1", "SHMT2", "SIGMAR1", "SIN3A", "SIRT1", "SKIV2L", "SKIV2L2", "SLC1A5", "SLC27A4", "SLFN11", "SLIRP", "SLIT2", "SLK", "SLTM", "SMAP1", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCE1", "SMN1*", 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0000000000000000000000000000000000000000..c85ad18f4c67c6da1675ff0a1480d86aa486bf7e --- /dev/null +++ b/protein_atlas_protein_class/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:dc61c83336c81cf77fb56328ad784a09ad73576bbe5c07ac31944c91ec8a8f1b +size 93877 diff --git a/protein_atlas_protein_class/df_merge.tsv b/protein_atlas_protein_class/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..9965e40d6ad3276b5f592926b738e1a6ba9be55e --- /dev/null +++ b/protein_atlas_protein_class/df_merge.tsv @@ -0,0 +1,4 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Predicted membrane proteins 333 572 5.01839476025225 5.210502380932039e-07 204.61650485436897 563.8058252427185 3.080866334016093 0.3028099075873978 81.17076282318972 73.52280648113661 4.068861305085399 0.4187410497068249 1.846176566476019e-70 8.971477088332382e-12 2.248426429611327e-25 1.7062447978992036e-53 5.809483027570015e-69 +Predicted secreted proteins 26 49 2.452284365872202 0.0141952431444574 15.29368932038835 51.737864077669904 1.393291060716792 0.256881456821794 5.463351773637434 6.9884942404294375 1.5049506819867255 0.3173597508227758 0.0233566437934742 0.1386157823902389 0.253349779059715 0.0558557877395337 0.0306495456467894 +Transporters 171 374 2.308797246204175 0.0209548349165322 108.9004854368932 367.3009708737864 1.469396346451591 0.4764419032567517 40.40141182476491 35.10022679965902 2.352674986871393 0.4490473364946538 1.4608915351251847e-33 8.459788983449556e-05 1.567465725021218e-05 5.106205061318245e-16 2.2596685298328845e-33 diff --git a/protein_atlas_protein_class/metrics.json b/protein_atlas_protein_class/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..eca49bda69ac0c25d038bd3eea03c46668bb1434 --- /dev/null +++ b/protein_atlas_protein_class/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2974, + "annotations_size": 20, + "title": "Average number of proteins per term", + "value": 480.0 +} \ No newline at end of file diff --git a/protein_atlas_protein_class/paths.json b/protein_atlas_protein_class/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..e78538939c43b3d7bc96033e36e7af29440fe74b --- /dev/null +++ b/protein_atlas_protein_class/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/protein_atlas_protein_class/fragment/C220/C220_val_log2fc"} \ No newline at end of file diff --git a/protein_atlas_protein_class/result.tsv b/protein_atlas_protein_class/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..ef69257ce02cf5bedbbd73c1d7f940f8133fb66a --- /dev/null +++ b/protein_atlas_protein_class/result.tsv @@ -0,0 +1,9 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Predicted membrane proteins 0.709921409667635 5.01839476025225 5.210502380932039e-07 1.0420953178308728e-05 3.47366825396136e-06 572 O43169,Q99595,Q9Y2R0,O60830,Q96A26,Q8WY22,Q8N0U8,O95197,Q15800,Q9C0H2,O43657,Q9H061,Q969V3,Q8N511,P30519,O95772,Q70HW3,O60637,Q96CP7,Q9UBX3,Q9Y282,Q9UDW1,O75964,Q9NS69,Q9Y5M8,P24390,P00846,Q9NX00,O43676,Q6NXT4,Q9HC07,Q6PI78,Q86UE4,Q8N5M9,Q9H8H3,Q15629,O60499,Q8N8Q8,O94919,P43307,Q6ZT21,Q15392,Q15070,Q9NZ45,Q9HD45,Q13505,Q9P2W9,O15173,Q5VW38,Q567V2,Q8N2A8,O00461,Q9BQE5,O75844,Q8N2H4,Q3SXM5,Q9NQC3,Q96ES6,O15127,Q9H6K4,Q9H6V9,P51648,Q9Y619,Q16739,P03886,Q86YN1,Q93050,Q9BSK2,Q8NBN3,Q96A57,Q8IUX1,Q8NF37,Q9NR77,Q6NTF9,Q14108,Q8WU17,P09601,P67812,A1L0T0,Q9H1E5,P12235,Q9P035,Q9UDX5,O43760,O00264,Q08722,Q9NUQ2,Q8IUH4,O00400,P13073,Q96G23,O95470,Q7Z3D4,O14925,Q86Y39,Q9H3K2,O60725,Q6ZXV5,Q9H3H5,Q14849,Q9NZ01,Q96A33,Q8NHP6,Q13423,Q4ZIN3,Q03518,O15260,Q96GQ5,Q9H4I3,Q8IZA0,Q9BTX1,Q9H490,Q9NZJ7,Q9HD20,P35613,P57105,Q9BUR5,O75438,Q14534,Q14739,Q16850,Q8TAD4,Q9BT22,Q9BXS4,Q9Y6C9,Q96FV9,P24539,P53985,O75071,P37268,Q8NCH0,Q8WVC6,Q9P0J0,O96005,Q9GZP9,P12236,P11117,Q9NQX7,O76024,Q07065,Q96AQ8,Q6UW02,Q9BV10,Q8TAA9,O43819,O75298,Q96KA5,Q9GZM5,Q9BUN8,Q15041,P27544,O15118,O95202,Q9NX40,O15121,Q15043,Q9NW15,Q8TB61,Q6NUQ4,O95674,Q6UW68,Q9NR28,O15258,Q8WTV0,Q96N66,O15269,Q15363,Q9HC21,P35610,O95070,Q5SNT2,Q53GQ0,Q9H3N1,Q96AA3,Q70UQ0,P00403,Q8N8L6,Q5J8M3,P05023,P10321,P05141,Q9H2J7,Q9H6H4,O95139,P46977,Q99735,P57088,Q7L0J3,Q9NX62,Q00325,Q86XL3,Q8IV08,Q12981,P38435,O75381,Q96PC5,Q9UG56,P33527,Q9NPA0,P11279,P42892,Q99805,O00767,Q8NHH9,Q9Y320,Q9Y487,Q15005,P27105,P16615,Q13190,Q9Y5Y5,O75027,Q5BJF2,Q96SK2,Q9Y3B3,P50402,Q8NE01,Q9NWS8,Q8N6S5,Q4KMQ2,Q6Y1H2,O14880,Q15904,Q92542,Q86VD7,Q06136,O95168,Q9UBV2,P62942,Q96S66,Q8IY17,P51571,O43292,P60228,Q96JJ7,Q9BU23,O95864,P35670,Q9H0U3,Q92804,Q10472,Q00765,Q96AG4,Q8WUK0,Q96KC8,Q9UIQ6,Q5T9L3,P27824,O95831,P16435,O14828,Q969M3,Q99720,Q9UBM7,P51572,Q6P4Q7,Q96ND0,Q2TAA5,P08183,Q12846,Q6NUM9,Q15631,Q14012,Q8IYS2,P51798,P51812,Q9UNK0,Q8IY95,Q15388,Q96RQ1,O75880,P08574,Q86Y82,O43808,Q6P4A7,P04439,Q8NBX0,Q9BVC6,Q92604,Q8NCC3,Q5VV42,Q8N2K0,P41440,O14735,O43493,P13473,Q86VR2,Q8IXU6,Q9Y2W6,Q9UI14,Q9NPF0,P51790,Q13586,P20020,P01889,Q9NV96,Q8NBU5,Q96NB2,Q99442,Q9H936,Q9NTJ5,Q9Y385,Q92643,O60831,P49755,Q8IWA4,Q16880,Q92544,Q06481,O15400,P60059,Q8TBQ9,Q9Y3E0,Q9BTV4,O43674,Q3ZCQ8,P05067,O95249,O75915,Q9HCU5,Q9UM00,Q9BXK5,O75396,Q16625,Q9UH99,Q07820,P02786,Q15758,Q9H9B4,O75192,P28288,Q9BSR8,Q12907 333 +Predicted secreted proteins 0.4746935559611323 2.452284365872202 0.0141952431444574 0.2486916960796912 0.0567809725778296 49 Q02818,Q9Y4P3,Q9UM22,P10909,P43490,P07858,Q9BTY2,P80303,Q96DX4,Q15165,Q9BUR5,Q9HB40,O94919,Q8WUJ1,P14174,Q99584,Q07021,P05067,P22466,Q9NZ08,Q08380,Q8N128,P02786,P04083,O60888,O75718 26 +Transporters 0.5561739194081955 2.308797246204175 0.0209548349165322 0.3452816084820025 0.0698494497217742 374 Q9BVC6,Q96P70,Q8WY22,Q9C0H2,Q9H061,Q969V3,Q8N511,P41440,Q70HW3,P13473,Q15006,O60637,Q8IXU6,Q9UBX3,P45880,Q9UI14,Q13586,P20020,P24390,Q9NV96,Q6NXT4,Q96NB2,Q9HC07,Q9H2D1,P07602,Q99442,Q9H936,Q15629,O60831,Q8N8Q8,P49755,P61421,Q15070,Q8IWA4,Q92544,P60059,Q5VW38,P78406,O75844,O15127,Q07021,P05067,Q9Y619,Q16739,O75746,O75915,Q93050,Q9BSK2,Q9HCU5,Q96A57,Q9UM00,Q8IUX1,Q9NR77,Q6NTF9,Q14108,Q16625,Q9UH99,P02786,Q15758,P12235,Q9H9B4,O75192,Q08722,Q8IUH4,O00400,P13073,Q6ZXV5,Q14849,Q96A33,Q03518,O15260,Q9BTX1,Q9NZJ7,Q9HD20,P35613,P57105,Q9BUR5,Q8NFH5,Q8TAD4,Q9BXS4,Q9Y6C9,Q9BQT8,P53985,O96005,Q9GZP9,P12236,O76024,Q07065,P21912,Q8TAA9,Q9GZM5,Q9BUN8,O15118,O95202,Q15043,Q9NW15,Q8TB61,Q6UW68,Q92973,O15258,Q8WTV0,Q96N66,Q15363,Q9HC21,Q9UJS0,Q9Y512,Q9H3N1,Q96AA3,P00403,Q5J8M3,P05023,Q9NQZ5,P05141,Q9H2J7,O00505,P46977,P57088,Q00325,O75381,Q96PC5,P33527,Q9NPA0,P11279,Q99805,Q8NHH9,Q9Y320,P27105,P16615,Q13190,Q9Y5Y5,O75027,Q5BJF2,Q9Y3B3,Q8NE01,Q4KMQ2,O60313,Q15904,Q86VD7,Q6NUK1,Q9UBV2,P62942,Q96S66,P40855,O75477,Q96JJ7,P35670,Q9H0U3,Q9Y371,Q96AG4,P52292,O96008,O75955,O43681,Q8IYU8,Q5T9L3,Q9BRK5,O14828,Q99720,P51572,Q6P4Q7,P08183,Q12846,P51798,Q9UHB9,Q8IY95,O43808,P04083,Q6P4A7,P04439,P53007,Q16891 171 +Disease related genes 0.2502680642999263 1.6617199127183109 0.0965689466091348 0.8688101343314344 0.2145976591314107 936 Q9NQT5,Q9Y2R0,Q53H12,Q9UMS0,P09622,Q15800,Q5VV42,Q9H061,Q8N2K0,Q8N511,Q9BRT2,Q53FT3,Q70HW3,Q9UHX1,P50897,P13473,Q01844,Q9NPF0,Q16836,Q13586,P01889,Q01105,P00846,P04062,Q96DA6,O43676,Q8NBU5,Q9HC07,Q9H2D1,P07602,Q6PI78,Q15436,Q9H936,Q13432,Q8N5M9,Q9NRA0,Q9UHD9,Q92643,O14949,Q15392,O75844,P35270,Q9H6K4,Q13510,P51648,Q9Y619,P03886,P10619,Q8IUX1,Q14108,Q8WU17,Q9NWM8,P09601,Q5XKP0,P12235,P53701,P21964,O00400,P13073,O95470,Q86Y39,Q6ZXV5,Q9H3H5,Q9NZ01,Q96A33,Q8WWV3,Q13126,Q13423,Q03518,Q15437,Q969T9,Q96DX4,Q9H490,O43924,P17900,Q14739,Q9BT22,Q96CU9,Q9BQT8,P53985,O14773,P37268,P23786,Q8NCH0,Q9P0J0,P11117,O76024,Q9BV10,P21912,O43505,Q8TAA9,O43819,O75298,Q15041,P27544,O15118,O15121,Q15043,Q9NW15,Q15067,P54136,Q99797,Q9NR28,P22695,Q96N66,O15269,Q9HC21,O75503,Q9UJS0,O14979,P54802,Q16740,Q96AA3,P00403,Q10713,P05023,P10321,P16278,P46977,Q9Y6M9,Q9NX62,Q00325,Q86XL3,Q8IV08,P22830,P38435,O75381,Q96PC5,Q00059,O75569,P33527,P42892,Q9Y320,Q96AY3,Q9Y487,P16615,P07099,P06280,P10253,Q9NVI7,Q9Y5Y5,P28070,O75027,P50402,Q9NWS8,Q4KMQ2,O60313,Q15904,Q92542,Q86VD7,Q9NSD9,Q6NUK1,Q06136,Q13043,Q9BW92,Q96S66,O75208,O75718,P00374,P40855,Q8IY17,P51571,O75477,Q6PGP7,P17050,O43292,Q03164,Q9Y4P3,P55795,P35670,Q9H0U3,Q15058,Q92804,P07858,Q86YV9,P22626,Q9H9P8,Q71SY5,O95831,P16435,Q6PJG6,Q9HCC0,Q5JTZ9,Q99720,Q9UBM7,O00116,P51572,Q6P4Q7,Q2TAA5,P08183,P14174,P06865,P40939,P51649,P51798,P08670,P51812,Q96J02,Q16637,P35637,O75880,P08574,Q6P4A7,P38646,P04439,P53007,Q4J6C6 207 +CD markers 0.4641872565138025 1.2797424090661766 0.2006357442521511 0.9886526489629884 0.3343929070869186 16 P08183,P11279,P35613,P13473,Q9NPF0,Q08722 6 +Metabolic proteins 0.2817321897566064 0.7486573730851059 0.4540637422236586 0.9999944685528231 0.5341926379101867 846 Q9Y680,Q15800,P43490,P30519,Q70HW3,P50897,Q9UBX3,Q9UDW1,O75964,P00846,P04062,O43676,Q6NXT4,Q9H2D1,P07602,Q9H773,Q9H8H3,O14949,Q6ZT21,Q15392,Q8N2A8,Q9UHG3,Q9UMR5,O75844,Q8N4Q0,P35270,Q13510,P51648,Q9BRR6,Q9Y619,Q16739,P03886,Q86YN1,Q93050,P10619,Q8NF37,Q8WU17,Q9NWM8,P09601,O95302,P67812,P12235,P53701,P21964,Q9P035,Q9NUQ2,Q8IUH4,O00400,P13073,Q05D32,Q96G23,O95470,P49354,Q86Y39,O60725,Q9H3H5,Q14849,Q9NZ01,Q13126,Q13423,Q9BTX1,Q9H490,Q8N4A0,O75438,O43924,P17900,Q9BW91,Q8NFH5,Q969T7,Q14534,Q14739,Q16850,Q9BT22,Q9BQT8,P24539,P53985,O14773,P37268,P23786,Q8NCH0,Q9P0J0,P12236,P11117,Q9BV10,P21912,O43505,P52789,Q8NBN7,P27544,O15118,Q9BWD1,O15121,Q15043,Q15067,Q8TB61,P54136,O95674,P13674,P22695,Q8WTV0,Q96N66,O15269,Q9HC21,P35610,Q9UJS0,Q53GQ0,P54802,P00403,Q10713,Q9BTY2,P05023,O96000,Q7LGA3,P16278,Q9NQZ5,P05141,Q9H2J7,O95139,P46977,Q16539,Q99735,Q9Y6M9,Q9NX62,Q00325,Q8IV08,P22830,Q9UG56,P33527,O00767,Q8NBQ5,Q96AY3,Q9Y487,Q15005,P16615,P07099,P06280,P49327,P10253,Q6Y1H2,O14880,Q15904,Q86VD7,Q9NSD9,Q06136,Q13043,O95168,P62942,P00374,Q8IY17,P51571,P35269,P17050,O43292,Q03164,Q96JJ7,O95864,Q9Y371,P07858,Q10472,Q8WUK0,Q9H9P8,P16435,Q15165,Q9HCC0,P30154,Q9UBM7,O00116,P51572,Q2TAA5,P08183,P14174,Q14012,O15254,P06865,P40939,P51649,Q9BY49,Q9UBF8,P51812 179 +FDA approved drug targets 0.322934937381153 0.6951008358484584 0.4869921109924542 0.9999984060273168 0.5411023455471713 114 P35610,Q8N0U8,P49354,P05023,Q13423,P05141,Q7L0J3,P38435,Q14534,Q16850,P33527,P49721,P23786,P16615,P12236,P49327,P10253,Q16739,P03886,P12235,P62942,P21964,P00374 23 +Human disease related genes 0.2711996416268233 0.5655445118611518 0.5717034573237638 0.9999999568588842 0.601793112972383 852 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194 diff --git a/protein_atlas_protein_class/selections.json b/protein_atlas_protein_class/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..54b7dd495a915f5da086dd8cc6899709d3df7216 --- /dev/null +++ b/protein_atlas_protein_class/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["Blood group antigen proteins", "CD markers", "Cancer-related genes", "Candidate cardiovascular disease genes", "Citric acid cycle related proteins", "Disease related genes", "Enzymes", "FDA approved drug targets", "Human disease related genes", "Metabolic proteins", "Plasma proteins", "Potential drug targets", "Predicted intracellular proteins", "Predicted membrane proteins", "Predicted secreted proteins", "RAS pathway related proteins", "RNA polymerase related proteins", "Ribosomal proteins", "Transcription factors", "Transporters"], "available_proteins": ["AAAS", "AAMP", "AAR2", "AARS", "AARS2", "AASDHPPT", "AASS", "AATF", "ABCB1", "ABCB7", "ABCC1", "ABCD3", "ABCE1", "ABCF1", "ABCF2", "ABCF3", "ABHD10", "ABHD12", "ABHD14B", "ABHD6", "ABI1", "ACAA2", "ACACA", "ACACB", "ACAD11", "ACAD9", "ACADM", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACBD5", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT9", "ACOX1", "ACOX3", "ACP1", "ACP2", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN4", "ACTR10", "ACTR1A", "ACTR1B", "ACTR2", "ACTR3", "ADAR", "ADD1", "ADD3", "ADH5", "ADI1", "ADNP", "ADPGK", "ADPRHL2", "ADRM1", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGK", "AGL", "AGPAT1", "AGPAT5", "AGPS", "AHCY", "AHCYL1", "AHNAK", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AKAP12", "AKAP13", "AKAP8", "AKAP8L", "AKR1A1", "AKR1B1", "AKR7A2", "AKT2", "ALDH18A1", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALG1", "ALG11", "ALG12", "ALKBH5", "AMOT", "ANAPC1", "ANAPC16", "ANAPC2", "ANAPC5", "ANAPC7", "ANGEL1", "ANKFY1", "ANKHD1", "ANKLE2", "ANKRD17", "ANO10", "ANO6", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA3", "ANXA4", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP1M1", "AP1S2", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "AP3S1", "APEH", "APEX1", "API5", "APLP2", "APMAP", "APOL2", "APOO", "APOOL", "APP", "APRT", "AQR", "ARAF", "ARCN1", "ARF4", "ARF6", "ARFGAP1", "ARFGAP2", "ARFIP1", "ARFIP2", "ARGLU1", "ARHGAP1", "ARHGAP17", "ARHGDIA", "ARHGEF1", "ARHGEF2", "ARID1A", "ARID3B", "ARIH1", "ARIH2", "ARL1", "ARL10", "ARL2", "ARL3", "ARL6IP1", "ARL6IP5", "ARL6IP6", "ARMC10", "ARMC6", "ARMC8", "ARMCX3", "ARMT1", "ARPC1A", "ARPC2", "ARPC3", "ARPC4", "ARPC5", "ASAH1", "ASCC2", "ASCC3", "ASNA1", "ASNS", "ASPH", "ATAD1", "ATAD2", "ATAD3A", "ATAD3B", "ATE1", "ATG3", "ATG4B", "ATG7", "ATG9A", "ATIC", "ATL2", "ATP13A1", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6", "ATP6AP1", "ATP6AP2", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1D", "ATP6V1E1", "ATP6V1H", "ATP7B", "ATPAF1", "ATPIF1", "ATRIP", "ATXN10", "ATXN2L", "AUP1", "AURKA", "AURKB", "B3GALT6", "B4GAT1", "BABAM1", "BAG2", "BAG4", "BAG5", "BAG6", "BAIAP2", "BAK1", "BANF1", "BANP", "BASP1", "BAZ1A", "BAZ1B", "BCAP31", "BCAS2", "BCCIP", "BCL2L13", "BCLAF1", "BCS1L", "BICD2", "BIRC6", "BLMH", "BLVRA", "BMS1", "BNIP1", "BOD1", "BOLA2*", "BOP1", "BPHL", "BPNT1", "BRAP", "BRAT1", "BRD2", "BRI3BP", "BRIX1", "BSDC1", "BSG", "BTAF1", "BTF3", "BUB1B", "BUB3", "BUD23", "BUD31", "BYSL", "BZW1", "BZW2", "C11orf58", "C12orf73", "C16orf58", "C17orf75", "C19orf70", "C1QBP", "C1orf35", "C21orf59", "C2CD5", "C5orf51", "CAB39", "CACUL1", "CACYBP", "CAD", "CALD1", "CALM3", "CALR", "CALU", "CAMK1", "CAMK2G", "CAND1", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPRIN1", "CAPZA1", "CAPZA2", "CAPZB", "CARM1", "CARS", "CARS2", "CASK", "CAST", "CBR1", "CBX1", "CBX3", "CBX5", "CBX8", "CCAR1", "CCAR2", "CCDC124", "CCDC134", "CCDC138", "CCDC22", "CCDC47", "CCDC6", "CCDC86", "CCNB1", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2AP", "CD2BP2", "CD320", "CD47", "CDC123", "CDC16", "CDC20", "CDC23", "CDC27", "CDC34", "CDC37", "CDC40", "CDC42", "CDC5L", "CDC7", "CDC73", "CDCA2", "CDCA8", "CDH2", "CDIPT", "CDK1", "CDK2", "CDK4", "CDK5", "CDK5RAP3", "CDK6", "CDKAL1", "CDS2", "CEBPZ", "CECR2", "CELF2", "CENPI", "CENPP", "CENPV", "CEP290", "CEP44", "CEP55", "CERS1", "CERS2", "CETN2", "CFAP20", "CFL1", "CFL2", "CHAC2", "CHAF1A", "CHAF1B", "CHAMP1", "CHCHD3", "CHD1", "CHD1L", "CHD4", "CHERP", "CHID1", "CHKA", "CHMP1A", "CHMP2A", "CHMP2B", "CHMP3", "CHMP4B", "CHMP5", "CHMP7", "CHORDC1", "CHRAC1", "CHST14", "CHTF18", "CIAPIN1", "CIP2A", "CIRBP", "CISD1", "CISD2", "CKAP2", "CKAP4", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLCC1", "CLCN3", "CLCN7", "CLGN", "CLIC1", "CLIC4", "CLINT1", "CLN5", "CLNS1A", "CLPB", "CLPP", "CLPTM1", "CLPTM1L", "CLPX", "CLTA", "CLTC", "CLU", "CLUH", "CMAS", "CMPK1", "CMSS1", "CMTR1", "CNDP2", "CNN3", "CNNM3", "CNNM4", "CNOT1", "CNOT10", "CNOT11", "CNOT2", "CNOT9", "CNP", "CNPY2", "COA3", "COA7", "COASY", "COG3", "COIL", "COLEC12", "COLGALT1", "COMMD1", "COMT", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS7A", "COPS8", "COPZ1", "COQ8A", "COQ9", "CORO1B", "CORO1C", "CORO7", "COTL1", "COX18", "COX2", "COX4I1", "COX5A", "COX5B", "COX6C", "CPD", "CPNE1", "CPNE3", "CPOX", "CPSF1", "CPSF2", "CPSF3", "CPSF6", "CPSF7", "CPT1A", "CPT2", "CPVL", "CRK", "CRKL", "CRNKL1", "CROT", "CRTAP", "CRYZL1", "CS", "CSDE1", "CSE1L", "CSK", "CSNK1A1", "CSNK2A2", "CSNK2B", "CSRP2", "CSTB", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTCF", "CTDSPL2", "CTNNA1", "CTNNAL1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTPS2", "CTR9", "CTSA", "CTSB", "CTSC", "CTTN", "CTTNBP2NL", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CUTA", "CWC15", "CWC27", "CWF19L1", "CXorf56", "CXorf57", "CYB5B", "CYB5D2", "CYB5R1", "CYB5R3", "CYC1", "CYFIP1", "CYFIP2", "CYP20A1", "CYP51A1", "DAD1", "DAG1", "DAP3", "DARS", "DARS2", "DAXX", "DAZAP1", "DBN1", "DBNL", "DBT", "DCAF13", "DCAF16", "DCAF7", "DCAKD", "DCD", "DCP1B", "DCPS", "DCTD", "DCTN1", "DCTN2", "DCTN3", "DCTN4", "DCTPP1", "DCUN1D1", "DCUN1D5", "DCXR", "DDAH2", "DDB1", "DDI2", "DDOST", "DDRGK1", "DDT", "DDX1", "DDX10", "DDX17", "DDX18", "DDX20", "DDX21", "DDX23", "DDX24", "DDX28", "DDX39A", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX50", "DDX51", "DDX52", "DDX54", "DDX55", "DDX56", "DDX6", "DEGS1", "DEK", "DENR", "DERL1", "DERL2", "DFFA", "DGKE", "DHCR24", "DHCR7", "DHFR", "DHPS", "DHRS1", "DHRS4", "DHRS7", "DHRS7B", "DHX15", "DHX16", "DHX29", "DHX30", "DHX36", "DHX37", "DHX38", "DHX40", "DHX57", "DHX8", "DHX9", "DIABLO", "DIAPH1", "DIAPH2", "DIAPH3", "DIDO1", "DIMT1", "DIS3", "DKC1", "DLAT", "DLD", "DLG3", "DLGAP5", "DLST", "DNAAF5", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC13", "DNAJC19", "DNAJC2", "DNAJC3", "DNAJC7", "DNAJC8", "DNAJC9", "DNM1L", "DNM2", "DNMT1", "DNPH1", "DNTTIP2", "DOCK7", "DOHH", "DOLPP1", "DPAGT1", "DPH2", "DPH5", "DPM1", "DPP3", "DPP9", "DPYSL2", "DPYSL5", "DRG1", "DRG2", "DSC3", "DSG2", "DSP", "DST", "DSTN", "DTYMK", "DUSP12", "DUSP3", "DUSP9", "DUT", "DYM", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNC1LI2", "DYNLL2", "EARS2", "EBNA1BP2", "ECD", "ECE1", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "ECSIT", "EDC3", "EDC4", "EDF1", "EDRF1", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EFCAB14", "EFL1", "EFTUD2", "EHD1", "EHD4", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B5", "EIF2D", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAC2", "ELAVL1", "ELMO2", "ELMOD2", "ELOA", "ELOB", "ELOC", "ELP1", "ELP2", "ELP3", "EMC1", "EMC2", "EMC4", "EMC7", "EMD", "EMG1", "EML4", "ENAH", "ENDOD1", "ENO1", "ENO2", "ENOPH1", "EPB41", "EPB41L2", "EPB41L3", "EPB41L5", "EPDR1", "EPHA7", "EPHX1", "EPHX2", "EPPK1", "EPRS", "EPS15L1", "ERAL1", "ERAP1", "ERC1", "ERCC2", "ERCC3", "ERCC6L", "ERGIC2", "ERGIC3", "ERH", "ERLIN1", "ERLIN2", "ERMP1", "ERO1A", "ERP29", "ERP44", "ESD", "ESF1", "ESPL1", "ESYT1", "ESYT2", "ETF1", "ETFA", "ETFB", "ETFDH", "ETNK1", "EWSR1", "EXO1", "EXOC2", "EXOC3", "EXOC5", "EXOC6", "EXOC6B", "EXOC7", "EXOC8", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC9", "EZR", "F11R", "FABP5", "FADS2", "FAF1", "FAF2", "FAH", "FAHD1", "FAM114A2", "FAM162A", "FAM177A1", "FAM192A", "FAM208A", "FAM210A", "FAM213A", "FAM3C", "FAM49B", "FAM50A", "FAM98A", "FAM98B", "FANCD2", "FANCI", "FAR1", "FARP1", "FARS2", "FARSA", "FARSB", "FASN", "FASTKD2", "FBL", "FBXO21", "FBXO22", "FCGRT", "FDFT1", "FDPS", "FDXR", "FECH", "FEN1", "FERMT2", "FGFR1OP", "FH", "FHL1", "FHOD1", "FIP1L1", "FIS1", "FKBP10", "FKBP14", "FKBP1A", "FKBP2", "FKBP3", "FKBP4", "FKBP5", "FKBP7", "FKBP8", "FKBP9", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FMR1", "FN3KRP", "FNTA", "FNTB", "FOXRED1", "FSCN1", "FTL", "FTO", "FTSJ3", "FUBP1", "FUBP3", "FUCA1", "FUCA2", "FUNDC2", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GADD45GIP1", "GAK", "GAL", "GALK1", "GALNT1", "GALNT2", "GALNT4", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GATAD2B", "GBA", "GBE1", "GBF1", "GCAT", "GCC2", "GCDH", "GCLC", "GCN1", "GDAP1", "GDI1", "GDI2", "GDPD1", "GEMIN4", "GEMIN5", "GET4", "GFM1", "GFPT1", "GGCT", "GGCX", "GGH", "GGPS1", "GHDC", "GHITM", "GIGYF2", "GINS2", "GINS3", "GINS4", "GLA", "GLB1", "GLDC", "GLG1", "GLMN", "GLO1", "GLOD4", "GLRX3", "GLS", "GLT8D1", "GLUD1", "GLYR1", "GM2A", "GMFB", "GMPPB", "GMPS", "GNA13", "GNAI2", "GNAI3", "GNG12", "GNL2", "GNL3", "GNL3L", "GNPAT", "GNPDA1", "GNS", "GOLGA2", "GOLGA3", "GOLGA5", "GOLGB1", "GOLIM4", "GOLM1", "GOLPH3", "GOLT1B", "GOPC", "GORASP2", "GOSR1", "GOT1", "GOT2", "GPAA1", "GPAM", "GPAT4", "GPATCH8", "GPD2", "GPHN", "GPI", "GPKOW", "GPR107", "GPR89B", "GPS1", "GPT2", "GRAMD1A", "GRB2", "GRHPR", "GRIPAP1", "GRPEL1", "GRSF1", "GRWD1", "GSPT1", "GSR", "GSS", "GSTK1", "GSTM3", "GSTO1", "GTF2B", "GTF2E1", "GTF2F1", "GTF2I", "GTF3C1", "GTF3C2", "GTF3C3", "GTPBP1", "GTPBP10", "GTPBP3", "GTPBP4", "GUF1", "GYG1", "GYS1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACD2", "HACD3", "HACL1", "HADH", "HADHA", "HADHB", "HAT1", "HAUS1", "HAUS3", "HAUS4", "HAUS5", "HBS1L", "HCCS", "HCFC1", "HDAC1", "HDAC2", "HDGF", "HDGFL2", "HDHD2", "HDHD5", "HDLBP", "HEATR1", "HEATR3", "HEATR6", "HEBP1", "HEBP2", "HECTD1", "HELLS", "HEXA", "HEXB", "HGH1", "HGS", "HIBADH", "HIBCH", "HIKESHI", "HINT2", "HINT3", "HIRIP3", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLTF", "HM13", "HMBS", "HMCES", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMGCL", "HMGCR", "HMGCS1", "HMGN2", "HMMR", "HMOX1", "HMOX2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPLL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HNRNPUL2", "HP1BP3", "HPRT1", "HPS6", "HS2ST1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSDL1", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA13", "HSPA14", "HSPA1B", "HSPA2", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPB1", "HSPBP1", "HSPD1", "HSPE1", "HSPH1", "HTATSF1", "HTRA2", "HUS1", "HUWE1", "HYOU1", "IARS", "IARS2", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDI1", "IFT27", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IK", "IKBIP", "IKBKG", "ILF2", "ILF3", "ILK", "ILKAP", "ILVBL", "IMMT", "IMP3", "IMP4", "IMPA1", "IMPAD1", "IMPDH1", "IMPDH2", "INA", "INCENP", "INTS11", "INTS14", "INTS3", "INTS7", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IQGAP2", "IRGQ", "IRS4", "ISOC1", "IST1", "ITCH", "ITGB1", "ITM2C", "ITPA", "IVD", "JAGN1", "JPT2", "JUP", "KARS", "KAT7", "KCTD12", "KCTD5", "KDELC2", "KDELR1", "KDM1A", "KDM1B", "KDM2A", "KDM3B", "KDSR", "KHDRBS1", "KHSRP", "KIAA0319L", "KIAA0368", "KIAA0391", "KIAA1147", "KIAA1468", "KIAA2013", "KIF11", "KIF14", "KIF15", "KIF18B", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF4A", "KIF5B", "KIFBP", "KIFC1", "KIN", "KLC1", "KLC2", "KLC4", "KMT2A", "KNTC1", "KPNA1", "KPNA2", "KPNA3", "KPNA6", "KPNB1", "KRI1", "KRR1", "KTN1", "L2HGDH", "LAMP1", "LAMP2", "LAMTOR1", "LANCL2", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LAS1L", "LASP1", "LBR", "LDAH", "LDHA", "LDHB", "LEMD2", "LEMD3", "LETM1", "LGALS3BP", "LGMN", "LIG1", "LIG3", "LIMA1", "LIPA", "LMAN2", "LMF2", "LMNA", "LMNB1", "LMNB2", "LNPEP", "LNPK", "LONP1", "LPCAT1", "LPCAT3", "LPGAT1", "LRBA", "LRP1", "LRPAP1", "LRPPRC", "LRRC1", "LRRC40", "LRRC47", "LRRC59", "LRWD1", "LSM12", "LSM2", "LSM3", "LSM4", "LSM6", "LSM7", "LSS", "LTA4H", "LTV1", "LUC7L", "LUC7L2", "LYAR", "LYPLA1", "LYRM2", "LYSMD3", "LZIC", "LZTFL1", "M6PR", "MACF1", "MAD2L1", "MAGED2", "MAGT1", "MAIP1", "MAK16", "MAN1A1", "MAN2A1", "MAN2B1", "MANF", "MAP1B", "MAP1S", "MAP2K2", "MAP4", "MAPK1", "MAPK14", "MAPRE1", "MAPRE2", "MARC1", "MARCH5", "MARS", "MASTL", "MAT2A", "MAT2B", "MATR3", "MAU2", "MAVS", "MBD3", "MBOAT7", "MCAT", "MCCC1", "MCCC2", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCMBP", "MCTS1", "MCU", "MCUR1", "MDC1", "MDH1", "MDH2", "MDN1", "ME1", "ME2", "MECP2", "MED21", "MED23", "MED24", "MED25", "MEPCE", "METAP2", "METTL13", "METTL14", "METTL3", "METTL7A", "METTL7B", "METTL9", "MFN1", "MFN2", "MFSD3", "MFSD5", "MGEA5", "MGME1", "MGST2", "MGST3", "MIA2", "MIA3", "MICU1", "MICU2", "MIF", "MINDY3", "MIPEP", "MKI67", "MKRN2", "MLEC", "MMAB", "MMS19", "MOB4", "MOGS", "MORF4L1", "MOSPD2", "MOV10", "MPC2", "MPDU1", "MPG", "MPHOSPH10", "MPI", "MPP1", "MPP6", "MPRIP", "MPST", "MPV17", "MPV17L2", "MRC2", "MRE11", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL14", "MRPL15", "MRPL17", "MRPL19", "MRPL21", "MRPL22", "MRPL23", "MRPL24", "MRPL28", "MRPL3", "MRPL37", "MRPL38", "MRPL39", "MRPL40", "MRPL44", "MRPL46", "MRPL50", "MRPL53", "MRPL55", "MRPL58", "MRPL9", "MRPS11", "MRPS15", "MRPS16", "MRPS18A", "MRPS22", "MRPS23", "MRPS25", "MRPS27", "MRPS30", "MRPS31", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRPS9", "MRRF", "MRTO4", "MSH2", "MSH3", "MSH6", "MSI2", "MSMO1", "MSN", "MSTO1", "MTA1", "MTA2", "MTAP", "MTBP", "MTCH1", "MTCH2", "MTDH", "MTFP1", "MTHFD1L", "MTHFD2", "MTMR14", "MTMR2", "MTOR", "MTPAP", "MTPN", "MTR", "MTX1", "MTX2", "MUT", "MVK", "MYBBP1A", "MYCBP", "MYDGF", "MYG1", "MYH10", "MYH9", "MYL6", "MYO1B", "MYO1C", "MYO1D", "MYO6", "NAA15", "NAA25", "NAA35", "NAA40", "NAA50", "NADK2", "NAE1", "NAF1", "NAGA", "NAGLU", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NAPG", "NARS", "NASP", "NAT10", "NAXE", "NCAPD2", "NCAPD3", "NCAPG", "NCAPG2", "NCAPH", "NCBP1", "NCBP3", "NCDN", "NCKAP1", "NCL", "NCLN", "NCSTN", "ND1", "NDC1", "NDUFA11", "NDUFA13", "NDUFA4", "NDUFA5", "NDUFA7", "NDUFA8", "NDUFA9", "NDUFAF2", "NDUFAF3", "NDUFAF4", "NDUFAF7", "NDUFB1", "NDUFB10", "NDUFB3", "NDUFB4", "NDUFB5", "NDUFB6", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS6", "NDUFS7", "NDUFS8", "NDUFV1", "NDUFV2", "NECAP2", "NEFL", "NEFM", "NEK9", "NELFCD", "NELFE", "NEMF", "NENF", "NES", "NFATC2IP", "NFU1", "NGDN", "NHP2", "NIFK", "NIP7", "NIPSNAP1", "NIPSNAP2", "NKRF", "NKTR", "NLE1", "NLN", "NLRX1", "NME1", "NMT1", "NNT", "NOA1", "NOB1", "NOC2L", "NOC3L", "NOC4L", "NOL10", "NOL11", "NOL6", "NOL7", "NOL8", "NOL9", "NOLC1", "NOM1", "NONO", "NOP14", "NOP16", "NOP2", "NOP53", "NOP56", "NOP58", "NOP9", "NOSIP", "NPC1", "NPC2", "NPEPPS", "NPLOC4", "NPM1", "NRDC", "NSA2", "NSD2", "NSDHL", "NSF", "NSMCE2", "NSUN2", "NSUN5", "NT5C2", "NT5C3B", "NT5DC1", "NT5DC2", "NTHL1", "NTMT1", "NTPCR", "NUB1", "NUBP2", "NUBPL", "NUCB1", "NUCB2", "NUCKS1", "NUDC", "NUDCD1", "NUDCD2", "NUDT1", "NUDT16L1", "NUDT21", "NUDT5", "NUDT9", "NUF2", "NUFIP2", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP160", "NUP188", "NUP205", "NUP210", "NUP214", "NUP35", "NUP37", "NUP43", "NUP50", "NUP54", "NUP58", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NUTF2", "NVL", "NXF1", "NXN", "OAT", "OCIAD1", "OCLN", "OCRL", "OGDH", "OGT", "OLA1", "OPA1", "OPA3", "OSBP", "OSBPL3", "OSBPL6", "OSBPL8", "OSBPL9", "OSGEP", "OTUB1", "OTUD4", "OTUD7B", "OXA1L", "OXCT1", "OXSR1", "P3H1", "P3H4", "P4HA1", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PAF1", "PAFAH1B1", "PAFAH1B2", "PAFAH1B3", "PAICS", "PAIP1", "PAIP2", "PAK1IP1", "PAK2", "PALLD", "PANK4", "PAPOLA", "PARG", "PARK7", "PARN", "PARP1", "PATL1", "PAWR", "PBDC1", "PBK", "PBRM1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCID2", "PCK2", "PCLAF", "PCM1", "PCMT1", "PCNA", "PCNP", "PCYOX1", "PDAP1", "PDCD11", "PDCD5", "PDCD6", "PDCD6IP", "PDCL3", "PDE12", "PDE6D", "PDHA1", "PDHB", "PDIA3", "PDIA4", "PDIA5", "PDIA6", "PDK3", "PDLIM1", "PDLIM5", "PDLIM7", "PDPR", "PDS5A", "PDS5B", "PDXDC1", "PDXK", "PEBP1", "PECR", "PEF1", "PELO", "PELP1", "PEPD", "PES1", "PEX11A", "PEX14", "PEX16", "PEX19", "PEX5", "PFAS", "PFDN2", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGM3", "PGP", "PGRMC1", "PGRMC2", "PHAX", "PHB", "PHB2", "PHC2", "PHF5A", "PHF6", "PHGDH", "PHIP", "PHKA1", "PI4K2A", "PI4KB", "PIBF1", "PICALM", "PIGK", "PIGS", "PIGT", "PIGU", "PIK3R4", "PIN4", "PINX1", "PIP4K2C", "PIR", "PISD", "PITHD1", "PITPNB", "PITRM1", "PKM", "PKMYT1", "PKN1", "PKN2", "PLA2G15", "PLAA", "PLBD2", "PLCG1", "PLD3", "PLD6", "PLEC", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLPBP", "PLRG1", "PLS3", "PM20D2", "PMF1", "PMPCA", "PMPCB", "PMVK", "PNKP", "PNN", "PNO1", "PNP", "PNPLA6", "PNPT1", "PODXL", "POFUT1", "POGZ", "POLA1", "POLA2", "POLD1", "POLD2", "POLD3", "POLDIP2", "POLDIP3", "POLE", "POLE3", "POLE4", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2B", "POLR2C", "POLR2D", "POLR2E", "POLR2F", "POLR2G", "POLR2L", "POLR3A", "POLR3C", "POLRMT", "PON2", "POP1", "POR", "PPA1", "PPA2", "PPAN", "PPAT", "PPIB", "PPIC", "PPID", "PPIF", "PPIH", "PPIL1", "PPIL3", "PPIL4", "PPM1G", "PPME1", "PPOX", "PPP1CA", "PPP1CB", "PPP1R10", "PPP1R12A", "PPP1R8", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP2R5E", "PPP3CA", "PPP4C", "PPP4R1", "PPP4R3A", "PPP5C", "PPP6C", "PPP6R3", "PPT1", "PPT2", "PPWD1", "PRAF2", "PRC1", "PRCC", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PREP", "PREPL", "PRIM1", "PRIM2", "PRKAA2", "PRKACA", "PRKAG1", "PRKAR1A", "PRKAR2A", "PRKCB", "PRKCSH", "PRKDC", "PRKRA", "PRMT1", "PRMT3", "PRMT5", "PRMT9", "PRPF19", "PRPF31", "PRPF38B", "PRPF39", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPSAP1", "PRPSAP2", "PRRC1", "PRRC2A", "PRRC2C", "PRTFDC1", "PSAP", "PSAT1", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD6", "PSMD7", "PSMD8", "PSMD9", "PSME1", "PSME2", "PSME3", "PSME4", "PSMG1", "PSPC1", "PTBP1", "PTCD3", "PTDSS1", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK7", "PTPA", "PTPMT1", "PTPN1", "PTPN11", "PTPRF", "PTRH2", "PUDP", "PUF60", "PUM1", "PUM3", "PURA", "PUS7", "PWP1", "PWP2", "PXMP2", "PXN", "PYCR1", "PYCR2", "PYCR3", "PYGB", "PYGL", "QARS", "QKI", "QRSL1", "QSOX2", "QTRT2", "RAB10", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB1B", "RAB21", "RAB24", "RAB31", "RAB39A", "RAB3GAP1", "RAB3GAP2", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RAB8A", "RAB9A", "RABAC1", "RABEP1", "RABEPK", "RABGAP1", "RABL6", "RAC1", "RACGAP1", "RACK1", "RAD21", "RAD23A", "RAD23B", "RAD50", "RAE1", "RAI14", "RALA", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP6", "RANBP9", "RANGAP1", "RAP2B", "RAPGEF2", "RARS", "RARS2", "RAVER1", "RBBP5", "RBBP6", "RBBP7", "RBM10", "RBM12", "RBM14", "RBM17", "RBM19", "RBM22", "RBM25", "RBM26", "RBM27", "RBM28", "RBM34", "RBM39", "RBM4", "RBM5", "RBM6", "RBM8A", "RBMX", "RBP1", "RCC1", "RCC2", "RCL1", "RCN1", "RCN2", "RDH11", "RDH13", "RDH14", "RDX", "RECQL", "REEP4", "REEP5", "RER1", "RETREG3", "RETSAT", "REXO4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RFT1", "RHBDD2", "RHEB", "RHOG", "RHOT1", "RHOT2", "RIDA", "RIF1", "RINT1", "RMC1", "RMDN1", "RMDN3", "RMND1", "RNASEH2A", "RNASET2", "RNF139", "RNF14", "RNF20", "RNF219", "RNF40", "RNH1", "RNPEP", "ROCK1", "RPA1", "RPA2", "RPAP1", "RPAP3", "RPF1", "RPF2", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPN1", "RPN2", "RPP30", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS28", "RPS29", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RPTOR", "RPUSD3", "RRBP1", "RRM1", "RRM2", "RRP1", "RRP12", "RRP15", "RRP1B", "RRP36", "RRP8", "RRP9", "RRS1", "RSL1D1", "RSL24D1", "RSPRY1", "RSU1", "RTCB", "RTN2", "RTN3", "RTN4", "RTN4IP1", "RTRAF", "RUFY1", "RUVBL1", "RUVBL2", "S100A11", "S100A13", "SAAL1", "SACM1L", "SAE1", "SAFB", "SAFB2", "SAMD4B", "SAMHD1", "SAMM50", "SAP18", "SAR1A", "SARM1", "SARNP", "SARS", "SARS2", "SART1", "SART3", "SBDS", "SCAF1", "SCAF4", "SCAMP1", "SCAMP2", "SCAMP3", "SCARB1", "SCARB2", "SCCPDH", "SCD", "SCFD1", "SCML2", "SCO1", "SCO2", "SCP2", "SCPEP1", "SCRIB", "SCRN1", "SDAD1", "SDCBP", "SDF4", "SDHA", "SDHB", "SDR39U1", "SEC11A", "SEC16A", "SEC22B", "SEC23A", "SEC23B", "SEC23IP", "SEC24A", "SEC24B", "SEC24C", "SEC24D", "SEC31A", "SEC61A1", "SEC61B", "SEC61G", "SEC62", "SEC63", "SEH1L", "SEL1L", "SENP3", "SEPHS1", "SEPT11", "SEPT2", "SEPT6", "SEPT7", "SEPT9", "SERBP1", "SERPINB6", "SERPINH1", "SET", "SEZ6L2", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFXN1", "SFXN2", "SFXN4", "SGPL1", "SGTA", "SH3GL1", "SH3GLB1", "SH3GLB2", "SHMT1", "SHMT2", "SIGMAR1", "SIN3A", "SIRT1", "SKIV2L", "SKIV2L2", "SKP1", "SKP2", "SLC12A9", "SLC16A1", "SLC19A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A17", "SLC25A19", "SLC25A20", "SLC25A21", "SLC25A22", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A33", "SLC25A4", "SLC25A40", "SLC25A42", "SLC25A5", "SLC25A6", "SLC27A4", "SLC30A5", "SLC30A6", "SLC33A1", "SLC35B2", "SLC35F2", "SLC39A14", "SLC3A2", "SLC4A1AP", "SLC4A7", "SLC6A15", "SLC9A3R1", "SLFN11", "SLIRP", "SLIT2", "SLK", "SLTM", "SMAP1", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC6", "SMG5", "SMN1*", "SMNDC1", "SMPD4", "SMS", "SMU1", "SMYD3", "SNAP23", "SND1", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPC", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNW1", "SNX1", "SNX12", "SNX17", "SNX19", "SNX2", "SNX27", "SNX3", "SNX4", "SNX5", "SNX6", "SNX9", "SOAT1", "SOD2", "SON", "SORD", "SPAG9", "SPART", "SPATA5", "SPATA5L1", "SPC24", "SPC25", "SPCS2", "SPECC1L", "SPEN", "SPHK2", "SPNS1", "SPR", "SPTAN1", "SPTBN1", "SPTBN2", "SPTLC1", "SPTLC2", "SQLE", "SQSTM1", "SRCAP", "SREK1", "SRI", "SRM", "SRP14", "SRP54", "SRP68", "SRP72", "SRP9", "SRPK1", "SRPK2", "SRPRA", "SRPRB", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF3", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSNA1", "SSR1", "SSR4", "SSRP1", "STAG1", "STAG2", "STAM", "STAMBP", "STARD3", "STARD3NL", "STARD7", "STAT1", "STAT3", "STAU1", "STAU2", "STIM1", "STIP1", "STK26", "STK4", "STMN1", "STOM", "STOML2", "STRAP", "STRBP", "STRN", "STT3A", "STT3B", "STX10", "STX12", "STX18", "STX3", "STX4", "STX5", "STX7", "STX8", "STXBP3", "STXBP4", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGP2", "SUGT1", "SUN1", "SUN2", "SUPT16H", "SUPT5H", "SUPT6H", "SUPV3L1", "SURF4", "SURF6", "SUZ12", "SV2A", "SYAP1", "SYMPK", "SYNCRIP", "SYNE2", "SYNGR2", "SYNJ2BP", "SYS1", "TAB1", "TACC3", "TADA3", "TAF15", "TAF6L", "TAGLN2", "TALDO1", "TAOK1", "TAP1", "TARDBP", "TARS", "TARS2", "TBC1D13", "TBC1D15", "TBC1D2B", "TBC1D4", "TBC1D9B", "TBCA", "TBCB", "TBCD", "TBCE", "TBL2", "TBL3", "TBRG4", "TCAF1", "TCEA1", "TCERG1", "TCOF1", "TCP1", "TDRKH", "TECR", "TELO2", "TERF2IP", "TES", "TEX10", "TEX264", "TFAM", "TFB1M", "TFCP2", "TFG", "TFIP11", "TFRC", "TGOLN2", "THOC1", "THOC2", "THOC3", "THOC5", "THOC6", "THOP1", "THRAP3", "THUMPD1", "THUMPD3", "THYN1", "TIA1", "TIAL1", "TIGAR", "TIMELESS", "TIMM10", "TIMM10B", "TIMM13", "TIMM17A", "TIMM17B", "TIMM23", "TIMM44", "TIMM50", "TIMM8B", "TIMM9", "TIPRL", "TJP1", "TK1", "TKT", "TLCD1", "TLN1", "TM9SF2", "TM9SF3", "TM9SF4", "TMA16", "TMCO1", "TMED10", "TMED2", "TMED4", "TMED5", "TMED7", "TMED9", "TMEM109", "TMEM126A", "TMEM126B", "TMEM14C", "TMEM160", "TMEM165", "TMEM167A", "TMEM192", "TMEM199", "TMEM201", "TMEM205", "TMEM209", "TMEM214", "TMEM230", "TMEM259", "TMEM30A", "TMEM33", "TMEM38B", "TMEM43", "TMEM59", "TMEM65", "TMEM87A", "TMEM97", "TMF1", "TMOD1", "TMOD3", "TMPPE", "TMTC3", "TMX1", "TMX2", "TMX3", "TMX4", "TNKS1BP1", "TNPO1", "TNPO2", "TNPO3", "TOE1", "TOMM20", "TOMM22", "TOMM34", "TOMM40", "TOMM5", "TOMM70", "TOP1", "TOP2A", "TOP2B", "TOR1AIP1", "TOR1B", "TOR3A", "TOX4", "TP53", "TP53I11", "TPD52", "TPD52L2", "TPI1", "TPM1", "TPM3", "TPM4", "TPP1", "TPP2", "TPR", "TPT1", "TPX2", "TRA2A", "TRA2B", "TRABD", "TRAF2", "TRAM1", "TRAP1", "TRAPPC5", "TRIM21", "TRIM25", "TRIM28", "TRIM33", "TRIP12", "TRIP13", "TRIR", "TRMT10C", "TRMT11", "TRMT1L", "TRMT2A", "TRMU", "TROVE2", "TRRAP", "TRUB1", "TSFM", "TSG101", "TSN", "TSNAX", "TSPAN3", "TSPAN6", "TSR1", "TST", "TTC1", "TTC19", "TTC26", "TTC37", "TTC38", "TTC4", "TTK", "TTLL12", "TTYH3", "TUBB", "TUBB2A", "TUBB2B", "TUBB3", "TUBB4B", "TUBB6", "TUBGCP2", "TUBGCP3", "TUBGCP4", 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"VPS29", "VPS33A", "VPS33B", "VPS35", "VPS37B", "VPS4A", "VPS4B", "VPS51", "VPS52", "VPS53", "VRK1", "VRK3", "WAPL", "WARS", "WASHC5", "WBP11", "WBP2", "WDHD1", "WDR1", "WDR11", "WDR12", "WDR18", "WDR26", "WDR3", "WDR34", "WDR36", "WDR41", "WDR43", "WDR46", "WDR48", "WDR5", "WDR6", "WDR61", "WDR70", "WDR75", "WDR77", "WDR82", "WFS1", "WIPI2", "WIZ", "WLS", "XAB2", "XPNPEP1", "XPNPEP3", "XPO1", "XPO4", "XPO5", "XPO7", "XPOT", "XRCC1", "XRCC5", "XRCC6", "XRN2", "YARS", "YARS2", "YBX1", "YBX3", "YIF1A", "YIPF3", "YIPF4", "YIPF5", "YKT6", "YLPM1", "YME1L1", "YRDC", "YTHDC1", "YTHDC2", "YTHDF3", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2", "ZC3H11A", "ZC3H14", "ZC3H15", "ZC3H18", "ZC3HAV1", "ZC3HC1", "ZCCHC3", "ZCRB1", "ZDHHC13", "ZFR", "ZFYVE16", "ZMPSTE24", "ZMYM2", "ZNF207", "ZNF280C", "ZNF281", "ZNF318", "ZNF326", "ZNF512", "ZNF512B", "ZNF622", "ZNF638", "ZPR1", "ZRANB2", "ZW10", "ZWINT", "ZYX"], "leading_proteins": ["AARS2", "ABCB1", "ABCB7", "ABCC1", "ABCD3", 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1.0488963291346586e-14 1.6610357935120607e-27 +Peroxisomes 7 14 2.0972698141658115 0.0359696974099625 5.322815533980583 14.701456310679612 0.4359129333192138 0.4564689114892047 2.679509416580786 1.5010345350043446 1.0794334084892987 0.3191667601086948 0.0022225400809937 1.0 1.0 0.396459747437317 0.0003232242639967 +Lipid droplets 4 10 2.046249095489483 0.0407318692282407 3.0072815533980584 9.62621359223301 0.341030817631545 0.5500740955075814 1.9327141206562328 1.0125869172856077 0.8582489651663355 0.3093604356540435 0.0041430328983952 0.0058373227860703 0.0014613866465803 0.0022630844960047 0.0046973513771782 diff --git a/protein_atlas_subcellular_location_all/metrics.json b/protein_atlas_subcellular_location_all/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..93e0dd83e9eafe63d5610b58edc15802454f8043 --- /dev/null +++ b/protein_atlas_subcellular_location_all/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2974, + "annotations_size": 33, + "title": "Average number of proteins per term", + "value": 138.03030303030303 +} \ No newline at end of file diff --git a/protein_atlas_subcellular_location_all/paths.json b/protein_atlas_subcellular_location_all/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..e65d9d28b73ed60b34de3ac6293d2d5d2cc92ec5 --- /dev/null +++ b/protein_atlas_subcellular_location_all/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/protein_atlas_subcellular_location_all/fragment/C220/C220_val_log2fc"} \ No newline at end of file diff --git a/protein_atlas_subcellular_location_all/result.tsv b/protein_atlas_subcellular_location_all/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..ea28098ef896f09b7ed62eeb2b197f09c80e1f0f --- /dev/null +++ b/protein_atlas_subcellular_location_all/result.tsv @@ -0,0 +1,11 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Nuclear membrane 0.4494458626146634 2.687130920267094 0.0072068699119443 0.2123392798611184 0.0619753445956167 61 P50402,O15260,Q9BVC6,Q8N6S5,Q9BTX1,Q96G23,Q5SNT2,P67812,Q9BW91,O14735,Q8NFH5,O95168,Q9H1E5,Q6UW68,Q14739,O94919,Q96SK2 17 +Endoplasmic reticulum 0.5186194900651484 2.534268218810474 0.0112682444719303 0.3119976327105763 0.0619753445956167 196 O43169,O15269,Q9Y680,Q9NR31,P35610,Q96G23,Q8N0U8,O95197,Q15800,O95470,O43292,Q9H3N1,Q14849,Q9NZ01,Q96A33,Q70UQ0,Q8NHP6,Q00765,Q96AG4,Q4ZIN3,Q03518,O15260,Q9H6H4,Q96KC8,Q99735,Q5T9L3,P27824,Q86XL3,Q86UE4,Q8IV08,Q12981,Q969M3,Q9UBM7,Q16850,Q96PC5,P43307,Q9BT22,P51572,Q8WUJ1,Q9P2W9,O43852,O00767,P37268,Q8NHH9,O96005,Q9GZP9,Q9NQC3,Q9BV10,P51648,Q5BJF2,Q96KA5,Q9BUN8,P50402,Q15041,Q96S66,Q96A57,P27544,Q8NF37,Q15043,Q92791,Q14257,Q6NUQ4,O95674,P13674,P51571,Q6UW68,P21964,Q9P035,Q8IY17,O00264,O75477 71 +Peroxisomes 0.609842475180209 2.0972698141658115 0.0359696974099625 0.7014668124444409 0.1680189605664932 14 O15254,Q15067,O43808,Q9BY49,O75381,O00116,P40855 7 +Lipid droplets 0.6738626404552653 2.046249095489483 0.0407318692282407 0.7464751462984911 0.1680189605664932 10 Q9H8H3,Q01105,Q8NF37,Q969V3 4 +Golgi apparatus 0.4372177236487906 1.7014851364883998 0.0888519265337228 0.9536087877968152 0.2665557796011686 171 Q8IUH4,Q02818,O95070,Q9H4A6,P35670,O43493,P50897,O60637,P16278,P80303,O75955,O15260,Q96GQ5,P24390,Q8IZA0,Q8N4A0,Q6NXT4,Q9HC07,Q9NX62,Q9BRK5,Q9HB40,P40616,Q969M3,O60499,Q8TAD4,Q9UG56,Q96ND0,Q9HD45,O75071,Q5VW38,O00461,Q8NCH0,Q8IYS2,Q8N4Q0,Q9NW68,Q13190,A4D1U4,O15127,Q9UBF8,Q9GZM5,Q93050,Q8NBN3,P55327,Q96RQ1,Q6NTF9,Q9NWM8,P09601,O95302,P67812,Q15043,Q86Y82,P04439,A1L0T0,Q6NUQ4,O15258,O43760 56 +Mitochondria 0.4574328603309054 0.9196560224066846 0.3577525409366426 0.99999954899742 0.7174051149129403 386 Q99595,Q9Y2R0,O60830,Q96A26,Q8WY22,Q53H12,Q5JRX3,P09622,Q9H7Z7,Q9BRT2,Q69YU5,Q70HW3,Q9UBX3,P45880,O75964,Q8N4H5,Q9NS69,Q16836,Q9Y5L4,Q8NBU5,Q96NB2,P51970,Q9H2D1,Q9H936,P11177,P35232,O14949,Q6ZT21,Q15070,Q9NZ45,Q8IWA4,Q16880,Q13505,Q9Y5J7,Q5T9A4,Q8N5N7,Q96I99,Q3SXM5,Q6DKK2,O43674,Q3ZCQ8,O15498,Q07021,Q8N183,Q9BXK5,Q8IUX1,O95302,Q5XKP0,Q9NQE9,Q07820,O75648,P12235,P53701,Q9H9B4,P82933,Q9UDX5,Q8TAE8,Q99623,Q8NI60,Q9NUQ2,P13073,O14925,Q86Y39,Q9H3K2,O43464,P36776,Q9Y277,Q5TC12,Q9NUJ1,Q13423,Q68CZ6,Q6PI48,Q9H4I3,P00367,O43772,Q6YN16,O00411,P31930,P49411,P57105,Q9BUR5,O75438,Q9BW91,O00483,O75352,Q9BYT8,Q9Y6C9,Q96CU9,P34897,P24539,P23786,Q86UT6,Q9P0J0,P12236,P21912,O43819,P52789,Q8NBN7,O95202,Q9NX40,O15121,Q99797,P13674,Q9NR28,P22695,Q9HC21,Q9UJS0,Q9Y512,Q16740,Q10713,Q7LGA3,Q9NQZ5,P05141,O95139,Q9Y6M9,Q00325,Q00059,Q96AY3,Q9NVI7,P28070,O75027,Q9NWS8,O60313,Q86VD7,Q6NUK1,O95168,O75208,P00374,Q9NX63,O43292,O96008,Q8WUK0,Q9H9P8,O43615,Q8IYU8,O95831,Q9HCC0,Q8WWC4,Q5JTZ9,Q96ND0,Q6UXV4,P40939,P51649,Q7Z7H8,Q15388,P56385,P08574,Q9Y394,Q9NUL7,Q6P4A7,P38646,Q16891 152 +Cell Junctions 0.3162737671373412 0.6535511716098277 0.51340101125505 0.9999999999525048 0.7366188422355064 45 Q9H1A3,P53985,Q86UT6,O43657,P43490,Q9BW91,Q6UW02,P33527 8 +Kinetochore 0.5296096904441483 0.1834737477988011 0.8544263153482299 1.0 1.0 2 Q9BZD4 1 +Lysosomes 0.3109061064925071 0.1631781405412018 0.8703781768342302 1.0 1.0 14 Q8IY95,O15400,Q8WTV0 3 +Centriolar satellite 0.2656469811370964 0.0721427172270281 0.9424883313383532 1.0 1.0 26 O43169,Q14498,Q00013,P41208,Q86UY6,Q9UBK9,Q9Y4W2,Q03518 8 diff --git a/protein_atlas_subcellular_location_all/selections.json b/protein_atlas_subcellular_location_all/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..b1ca72915cba8490ee9dae169be5746401076c8a --- /dev/null +++ b/protein_atlas_subcellular_location_all/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["Actin filaments", "Cell Junctions", "Centriolar satellite", "Centrosome", "Cytokinetic bridge", "Cytoplasmic bodies", "Cytosol", "Endoplasmic reticulum", "Endosomes", "Focal adhesion sites", "Golgi apparatus", "Intermediate filaments", "Kinetochore", "Lipid droplets", "Lysosomes", "Microtubule ends", "Microtubules", "Midbody", "Midbody ring", "Mitochondria", "Mitotic chromosome", "Mitotic spindle", "Nuclear bodies", "Nuclear membrane", "Nuclear speckles", "Nucleoli", "Nucleoli fibrillar center", "Nucleoli rim", "Nucleoplasm", "Peroxisomes", "Plasma membrane", "Rods & Rings", "Vesicles"], "available_proteins": ["AAAS", "AAMP", "AAR2", "AARS", "AARS2", "AASS", "AATF", "ABCB1", "ABCB7", "ABCC1", "ABCD3", "ABCE1", "ABCF1", "ABCF2", "ABCF3", "ABHD10", "ABHD14B", "ABHD6", "ABI1", "ACAA2", "ACACA", "ACAD9", "ACADM", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACBD5", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT9", "ACOX1", "ACOX3", "ACP1", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN4", "ACTR10", "ACTR1A", "ACTR1B", "ACTR2", "ADAR", "ADD1", "ADD3", "ADI1", "ADNP", "ADPGK", "ADPRHL2", "ADRM1", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGK", "AGL", "AGPAT1", "AGPAT5", "AGPS", "AHCY", "AHCYL1", "AHNAK", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AKAP12", "AKAP13", "AKAP8", "AKAP8L", "AKR1A1", "AKR1B1", "AKR7A2", "AKT2", "ALDH18A1", "ALDH1B1", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALG1", "ALG12", "ALKBH5", "AMOT", "ANAPC1", "ANAPC16", "ANAPC2", "ANAPC5", "ANAPC7", "ANGEL1", "ANKFY1", "ANKLE2", "ANKRD17", "ANO10", "ANO6", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA3", "ANXA4", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP1S2", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP3B1", "AP3D1", "AP3S1", "APEH", "APEX1", "API5", "APLP2", "APMAP", "APOO", "APOOL", "APP", "APRT", "AQR", "ARCN1", "ARF6", "ARFGAP1", "ARFGAP2", "ARFIP1", "ARFIP2", "ARGLU1", "ARHGAP1", "ARHGAP17", "ARHGDIA", "ARHGEF1", "ARID1A", "ARID3B", "ARIH1", "ARIH2", "ARL1", "ARL2", "ARL3", "ARL6IP1", "ARL6IP5", "ARL6IP6", "ARMC10", "ARMC6", "ARMC8", "ARMCX3", "ARMT1", "ARPC1A", "ARPC2", "ARPC3", "ARPC5", "ASCC2", "ASCC3", "ASNA1", "ASNS", "ASPH", "ATAD1", "ATAD2", "ATAD3A", "ATAD3B", "ATE1", "ATG3", "ATG4B", "ATG7", "ATG9A", "ATIC", "ATL2", "ATP13A1", "ATP1B3", "ATP2B1", "ATP5A1", "ATP5B", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6V0A1", "ATP6V0A2", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1D", "ATP6V1E1", "ATP6V1H", "ATP7B", "ATPAF1", "ATPIF1", "ATRIP", "ATXN10", "ATXN2L", "AUP1", "AURKA", "AURKB", "BABAM1", "BAG2", "BAG5", "BAG6", "BAIAP2", "BANF1", "BANP", "BASP1", "BAZ1B", "BCAP31", "BCAS2", "BCCIP", "BCL2L13", "BCLAF1", "BICD2", "BIRC6", "BLMH", "BLVRA", "BMS1", "BNIP1", "BOLA2*", "BOP1", "BPHL", "BPNT1", "BRAP", "BRAT1", "BRD2", "BRI3BP", "BRIX1", "BSDC1", "BSG", "BTAF1", "BTF3", "BUB1B", "BUB3", "BUD23", "BUD31", "BYSL", "BZW1", "BZW2", "C11orf58", "C12orf73", "C16orf58", "C17orf75", "C19orf70", "C1QBP", "C1orf35", "C2CD5", "C5orf51", "CAB39", "CACUL1", "CACYBP", "CAD", "CALD1", "CALR", "CALU", "CAMK1", "CAMK2G", "CAND1", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPRIN1", "CAPZA2", "CAPZB", "CARM1", "CARS", "CARS2", "CASK", "CAST", "CBR1", "CBX1", "CBX3", "CBX5", "CBX8", "CCAR1", "CCAR2", "CCDC124", "CCDC138", "CCDC22", "CCDC47", "CCDC6", "CCDC86", "CCNB1", "CCT2", "CCT3", "CCT4", "CCT6A", "CCT7", "CCT8", "CD2AP", "CD2BP2", "CD320", "CD47", "CDC123", "CDC20", "CDC27", "CDC34", "CDC37", "CDC40", "CDC42", "CDC5L", "CDC7", "CDC73", "CDCA2", "CDCA8", "CDH2", "CDIPT", "CDK1", "CDK2", "CDK4", "CDK5", "CDK5RAP3", "CDK6", "CDS2", "CEBPZ", "CECR2", "CELF2", "CENPI", "CENPP", "CENPV", "CEP290", "CEP55", "CERS1", "CERS2", "CETN2", "CFAP20", "CFL1", "CFL2", "CHAC2", "CHAF1A", "CHAF1B", "CHAMP1", "CHCHD3", "CHD1", "CHD1L", "CHD4", "CHID1", "CHKA", "CHMP1A", "CHMP2A", "CHMP2B", "CHMP5", "CHMP7", "CHORDC1", "CHRAC1", "CHST14", "CHTF18", "CIAPIN1", "CIP2A", "CIRBP", "CISD1", "CISD2", "CKAP2", "CKAP5", "CKB", "CLCC1", "CLCN3", "CLGN", "CLIC1", "CLIC4", "CLINT1", "CLNS1A", "CLPP", "CLPTM1", "CLPTM1L", "CLPX", "CLTA", "CLTC", 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"DCAF13", "DCAF16", "DCAF7", "DCAKD", "DCP1B", "DCPS", "DCTD", "DCTN1", "DCTN2", "DCTN3", "DCTN4", "DCTPP1", "DCUN1D1", "DCUN1D5", "DCXR", "DDAH2", "DDB1", "DDI2", "DDOST", "DDRGK1", "DDT", "DDX1", "DDX10", "DDX17", "DDX18", "DDX20", "DDX21", "DDX23", "DDX24", "DDX28", "DDX39A", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX50", "DDX51", "DDX52", "DDX54", "DDX55", "DDX56", "DDX6", "DEGS1", "DEK", "DENR", "DERL1", "DERL2", "DFFA", "DGKE", "DHCR7", "DHFR", "DHPS", "DHRS1", "DHRS4", "DHRS7", "DHRS7B", "DHX15", "DHX16", "DHX29", "DHX30", "DHX36", "DHX37", "DHX38", "DHX40", "DHX57", "DHX8", "DHX9", "DIABLO", "DIAPH1", "DIAPH2", "DIAPH3", "DIDO1", "DIMT1", "DIS3", "DKC1", "DLAT", "DLD", "DLG3", "DLGAP5", "DLST", "DNAAF5", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJC1", "DNAJC11", "DNAJC13", "DNAJC2", "DNAJC3", "DNAJC7", "DNAJC8", "DNAJC9", "DNM1L", "DNM2", "DNMT1", "DNPH1", "DNTTIP2", "DOHH", "DOLPP1", "DPH2", "DPH5", "DPP3", "DPP9", "DPYSL2", "DPYSL5", "DRG1", "DRG2", "DSC3", "DSG2", "DSP", "DST", "DTYMK", "DUSP12", "DUSP3", "DUSP9", "DUT", "DYM", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNC1LI2", "DYNLL2", "EARS2", "EBNA1BP2", "ECD", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "ECSIT", "EDC3", "EDC4", "EDF1", "EDRF1", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EFCAB14", "EFL1", "EFTUD2", "EHD1", "EHD4", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B5", "EIF2D", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAC2", "ELAVL1", "ELMO2", "ELMOD2", "ELOA", "ELOC", "ELP1", "ELP2", "ELP3", "EMD", "EMG1", "EML4", "ENAH", "ENDOD1", "ENO1", "ENO2", "ENOPH1", "EPB41", "EPB41L2", "EPB41L3", "EPB41L5", "EPHX2", "EPPK1", "EPRS", "EPS15L1", "ERAL1", "ERAP1", "ERC1", "ERCC2", "ERCC3", "ERCC6L", "ERGIC2", "ERH", "ERLIN1", "ERLIN2", "ERP29", "ESD", "ESF1", "ESPL1", "ESYT1", "ESYT2", "ETFA", "ETFB", "ETNK1", "EWSR1", "EXO1", "EXOC2", "EXOC3", "EXOC6", "EXOC6B", "EXOC7", "EXOC8", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC5", "EXOSC7", "EXOSC9", "EZR", "F11R", "FABP5", "FAF1", "FAF2", "FAH", "FAHD1", "FAM114A2", "FAM162A", "FAM177A1", "FAM192A", "FAM208A", "FAM210A", "FAM3C", "FAM49B", "FAM50A", "FAM98A", "FAM98B", "FANCD2", "FANCI", "FAR1", "FARP1", "FARSA", "FARSB", "FASN", "FASTKD2", "FBL", "FBXO21", "FDFT1", "FDPS", "FDXR", "FEN1", "FERMT2", "FGFR1OP", "FH", "FHL1", "FHOD1", "FIP1L1", "FIS1", "FKBP10", "FKBP14", "FKBP2", "FKBP3", "FKBP4", "FKBP5", "FKBP7", "FKBP8", "FKBP9", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FMR1", "FN3KRP", "FNTA", "FNTB", "FOXRED1", "FSCN1", "FTL", "FTO", "FTSJ3", "FUBP1", "FUBP3", "FUCA1", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GADD45GIP1", "GAK", "GAL", "GALK1", "GALNT2", "GALNT4", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GATAD2B", "GBE1", "GBF1", "GCAT", "GCC2", "GCDH", "GCLC", "GCN1", "GDAP1", "GDI1", "GDI2", "GEMIN4", "GEMIN5", "GET4", "GFM1", "GFPT1", "GGPS1", "GHITM", "GIGYF2", "GINS2", "GINS3", "GINS4", "GLB1", "GLDC", "GLG1", "GLMN", "GLO1", "GLOD4", "GLS", "GLT8D1", "GLUD1", "GLYR1", "GM2A", "GMFB", "GMPS", "GNA13", "GNAI2", "GNAI3", "GNG12", "GNL2", "GNL3", "GNL3L", "GNPDA1", "GOLGA2", "GOLGA3", "GOLGA5", "GOLGB1", "GOLIM4", "GOLM1", "GOLPH3", "GOLT1B", "GOPC", "GORASP2", "GOT1", "GPAA1", "GPAM", "GPATCH8", "GPD2", "GPHN", "GPI", "GPKOW", "GPR107", "GPR89B", "GPS1", "GPT2", "GRAMD1A", "GRB2", "GRHPR", "GRIPAP1", "GRPEL1", "GRSF1", "GRWD1", "GSPT1", "GSR", "GSS", "GSTK1", "GSTM3", "GTF2B", "GTF2E1", "GTF2F1", "GTF2I", "GTF3C1", "GTF3C2", "GTF3C3", "GTPBP1", "GTPBP3", "GTPBP4", "GUF1", "GYG1", "GYS1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACD3", "HACL1", "HADH", "HADHA", "HADHB", "HAT1", "HAUS1", "HAUS3", "HBS1L", "HCCS", "HCFC1", "HDAC1", "HDAC2", "HDGF", "HDGFL2", "HDHD2", "HDHD5", "HDLBP", "HEATR1", "HEATR3", "HEATR6", "HEBP1", "HECTD1", "HELLS", "HEXA", "HGH1", "HGS", "HIBCH", "HIKESHI", "HINT2", "HINT3", "HIRIP3", "HIST1H1C", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLTF", "HM13", "HMBS", "HMCES", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMGCS1", "HMGN2", "HMMR", "HMOX1", "HMOX2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPLL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HNRNPUL2", "HP1BP3", "HPRT1", "HS2ST1", "HSD17B11", "HSD17B4", "HSDL1", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA1B", "HSPA2", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPB1", "HSPBP1", "HSPD1", "HSPH1", "HTATSF1", "HTRA2", "HUWE1", "IARS", "IARS2", "IDH1", "IDH2", "IDH3A", "IDH3B", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IK", "IKBIP", "IKBKG", "ILF2", "ILF3", "ILK", "ILKAP", "ILVBL", "IMMT", "IMP3", "IMP4", "IMPAD1", "IMPDH1", "IMPDH2", "INA", "INCENP", "INTS11", "INTS14", "INTS3", "INTS7", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IQGAP2", "IRGQ", "ISOC1", "IST1", "ITCH", "ITGB1", "ITPA", "IVD", "JAGN1", "JPT2", "JUP", "KARS", "KAT7", "KCTD12", "KDELC2", "KDELR1", "KDM1A", "KDM1B", "KDM2A", "KDM3B", "KHDRBS1", "KHSRP", "KIAA0319L", "KIAA0368", "KIAA0391", "KIAA1147", "KIAA1468", "KIAA2013", "KIF11", "KIF14", "KIF18B", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF4A", "KIF5B", "KIFC1", "KIN", "KLC1", "KLC2", "KLC4", "KMT2A", "KNTC1", "KPNA1", "KPNA2", "KPNA3", "KPNA6", "KPNB1", "KRI1", "KRR1", "KTN1", "L2HGDH", "LAMP2", "LAMTOR1", "LANCL2", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LAS1L", "LASP1", "LBR", "LDHA", "LDHB", "LEMD2", "LEMD3", "LETM1", "LGMN", "LIG1", "LIG3", "LIMA1", "LIPA", "LMF2", "LMNA", "LMNB1", "LMNB2", "LNPK", "LONP1", "LPCAT1", "LRBA", "LRP1", "LRPAP1", "LRPPRC", "LRRC1", "LRRC40", "LRRC47", "LRRC59", "LRWD1", "LSM12", "LSM2", "LSM3", "LSM4", "LSM6", "LSM7", "LTA4H", "LTV1", "LUC7L", "LUC7L2", "LYAR", "LYPLA1", "LYRM2", "LYSMD3", "LZIC", "LZTFL1", "MACF1", "MAD2L1", "MAGED2", "MAIP1", "MAK16", "MAN1A1", "MAN2A1", "MAN2B1", "MANF", "MAP1B", "MAP1S", "MAP2K2", "MAP4", "MAPK1", "MAPK14", "MAPRE1", "MAPRE2", "MARC1", "MARCH5", "MARS", "MASTL", "MAT2A", "MAT2B", "MATR3", "MAU2", "MAVS", "MBD3", "MBOAT7", "MCAT", "MCCC1", "MCCC2", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCMBP", "MCTS1", "MCU", "MDC1", "MDH1", "MDH2", "MDN1", "ME1", "ME2", "MECP2", "MED21", "MED23", "MED25", "MEPCE", "METAP2", "METTL13", "METTL14", "METTL7A", "METTL7B", "METTL9", "MFN1", "MFN2", "MFSD3", "MGEA5", "MGME1", "MGST2", "MGST3", "MIA2", "MIA3", "MICU1", "MICU2", "MIF", "MINDY3", "MIPEP", "MKI67", "MKRN2", "MMAB", "MMS19", "MOGS", "MORF4L1", "MOSPD2", "MOV10", "MPDU1", "MPG", "MPHOSPH10", "MPI", "MPP1", "MPRIP", "MPST", "MRE11", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL14", "MRPL15", "MRPL19", "MRPL21", "MRPL22", "MRPL23", "MRPL28", "MRPL37", "MRPL38", "MRPL39", "MRPL40", "MRPL44", "MRPL46", "MRPL50", "MRPL53", "MRPL58", "MRPL9", "MRPS11", "MRPS15", "MRPS16", "MRPS22", "MRPS23", "MRPS25", "MRPS27", "MRPS31", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRPS9", "MRRF", "MRTO4", "MSH2", "MSH3", "MSH6", "MSI2", "MSMO1", "MSN", "MSTO1", "MTA1", "MTA2", "MTAP", "MTBP", "MTCH2", "MTDH", "MTFP1", "MTHFD1L", "MTHFD2", "MTMR2", "MTOR", "MTPAP", "MTPN", "MTR", "MTX1", "MTX2", "MUT", "MVK", "MYBBP1A", "MYCBP", "MYG1", "MYH10", "MYH9", "MYO1B", "MYO1C", "MYO1D", "MYO6", "NAA15", "NAA25", "NAA35", "NAA40", "NAA50", "NADK2", "NAE1", "NAF1", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NAPG", "NARS", "NASP", "NAT10", "NAXE", "NCAPD2", "NCAPD3", "NCAPG2", "NCAPH", "NCBP1", "NCBP3", "NCDN", "NCKAP1", "NCL", "NCLN", "NCSTN", "NDC1", "NDUFA11", "NDUFA13", "NDUFA4", "NDUFA7", "NDUFA8", "NDUFA9", "NDUFAF2", "NDUFAF4", "NDUFB1", "NDUFB4", "NDUFB5", "NDUFB6", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS8", "NDUFV1", "NDUFV2", "NECAP2", "NEFL", "NEFM", "NELFCD", "NELFE", "NEMF", "NES", "NFATC2IP", "NFU1", "NGDN", "NIFK", "NIP7", "NIPSNAP2", "NKRF", "NKTR", "NLE1", "NLN", "NLRX1", "NME1", "NMT1", "NNT", "NOA1", "NOB1", "NOC2L", "NOC3L", "NOC4L", "NOL10", "NOL11", "NOL6", "NOL7", "NOL8", "NOL9", "NOLC1", "NOM1", "NONO", "NOP14", "NOP16", "NOP2", "NOP53", "NOP56", "NOP58", "NOP9", "NOSIP", "NPC1", "NPEPPS", "NPLOC4", "NPM1", "NRDC", "NSA2", "NSD2", "NSDHL", "NSF", "NSMCE2", "NSUN2", "NSUN5", "NT5DC1", "NTMT1", "NTPCR", "NUB1", "NUBP2", "NUBPL", "NUCB1", "NUCB2", "NUCKS1", "NUDC", "NUDCD1", "NUDCD2", "NUDT1", "NUDT16L1", "NUDT21", "NUDT5", "NUDT9", "NUF2", "NUFIP2", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP188", "NUP35", "NUP37", "NUP43", "NUP50", "NUP54", "NUP62", "NUP85", "NUP88", "NVL", "NXF1", "NXN", "OAT", "OCIAD1", "OCLN", "OCRL", "OGDH", "OGT", "OLA1", "OPA1", "OPA3", "OSBP", "OSBPL3", "OSBPL6", "OSBPL8", "OSBPL9", "OSGEP", "OTUB1", "OTUD4", "OTUD7B", "OXA1L", "OXCT1", "OXSR1", "P3H1", "P3H4", "P4HA1", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PAF1", "PAFAH1B1", "PAFAH1B2", "PAFAH1B3", "PAICS", "PAIP1", "PAIP2", "PAK1IP1", "PAK2", "PALLD", "PANK4", "PAPOLA", "PARG", "PARK7", "PARN", "PARP1", "PATL1", "PAWR", "PBDC1", "PBK", "PBRM1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCID2", "PCK2", "PCLAF", "PCM1", "PCMT1", "PCNA", "PCNP", "PDAP1", "PDCD11", "PDCD5", "PDCD6", "PDCD6IP", "PDCL3", "PDHA1", "PDHB", "PDIA3", "PDIA4", "PDIA5", "PDIA6", "PDK3", "PDLIM1", "PDLIM5", "PDLIM7", "PDPR", "PDS5A", "PDS5B", "PDXDC1", "PDXK", "PEBP1", "PECR", "PEF1", "PELO", "PELP1", "PEPD", "PES1", "PEX14", "PEX19", "PEX5", "PFAS", "PFDN2", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PGAM1", "PGAM5", "PGD", "PGLS", "PGM1", "PGM2", "PGM3", "PGP", "PGRMC1", "PGRMC2", "PHAX", "PHB", "PHB2", "PHC2", "PHF5A", "PHF6", "PHGDH", "PHIP", "PHKA1", "PI4K2A", "PI4KB", "PIBF1", "PICALM", "PIGU", "PIK3R4", "PIN4", "PINX1", "PIP4K2C", "PIR", "PISD", "PITPNB", "PITRM1", "PKM", "PKMYT1", "PKN1", "PKN2", "PLA2G15", "PLAA", "PLCG1", "PLD3", "PLEC", "PLIN3", "PLOD1", "PLOD2", "PLPBP", "PLRG1", "PLS3", "PM20D2", "PMF1", "PMPCA", "PMPCB", "PNKP", "PNN", "PNO1", "PNP", "PNPLA6", "PNPT1", "PODXL", "POFUT1", "POGZ", "POLA1", "POLA2", "POLD1", "POLD2", "POLD3", "POLDIP2", "POLDIP3", "POLE", "POLE3", "POLE4", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2B", "POLR2C", "POLR2D", "POLR2E", "POLR2F", "POLR2G", "POLR2L", "POLR3A", "POLR3C", "POLRMT", "POP1", "POR", "PPA1", "PPA2", "PPAT", "PPIB", "PPID", "PPIF", "PPIL1", "PPIL3", "PPIL4", "PPM1G", "PPME1", "PPOX", "PPP1CA", "PPP1CB", "PPP1R10", "PPP1R12A", "PPP1R8", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP2R5E", "PPP3CA", "PPP4C", "PPP4R1", "PPP4R3A", "PPP5C", "PPP6R3", "PPT1", "PPT2", "PPWD1", "PRAF2", "PRC1", "PRCC", "PRCP", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PREP", "PRIM2", "PRKAA2", "PRKACA", "PRKAG1", "PRKAR1A", "PRKCB", "PRKCSH", "PRKDC", "PRKRA", "PRMT1", "PRMT5", "PRMT9", "PRPF19", "PRPF31", "PRPF39", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPSAP1", "PRPSAP2", "PRRC1", "PRRC2A", "PRRC2C", "PRTFDC1", "PSAP", "PSAT1", "PSIP1", "PSMA1", "PSMA4", "PSMA5", "PSMA6", "PSMB1", "PSMB2", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD12", "PSMD13", "PSMD14", "PSMD3", "PSMD4", "PSMD7", "PSMD8", "PSMD9", "PSME1", "PSME2", "PSME3", "PSME4", "PSMG1", "PSPC1", "PTBP1", "PTCD3", "PTDSS1", "PTGES2", "PTGES3", "PTGR2", "PTPA", "PTPMT1", "PTPN1", "PTPN11", "PTPRF", "PTRH2", "PUDP", "PUF60", "PUM1", "PUM3", "PUS7", "PWP1", "PWP2", "PXN", "PYCR2", "PYCR3", "PYGB", "PYGL", "QARS", "QKI", "QRSL1", "QSOX2", "QTRT2", "RAB13", "RAB14", "RAB1A", "RAB1B", "RAB24", "RAB3GAP1", "RAB3GAP2", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RAB8A", "RAB9A", "RABEP1", "RABEPK", "RABGAP1", "RABL6", "RAC1", "RACGAP1", "RACK1", "RAD21", "RAD23A", "RAD23B", "RAD50", "RAE1", "RAI14", "RALA", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP6", "RANBP9", "RANGAP1", "RAPGEF2", "RARS", "RARS2", "RAVER1", "RBBP5", "RBBP6", "RBBP7", "RBM10", "RBM12", "RBM14", "RBM17", "RBM19", "RBM22", "RBM25", "RBM26", "RBM27", "RBM28", "RBM34", "RBM39", "RBM4", "RBM5", "RBM6", "RBM8A", "RBMX", "RBP1", "RCC1", "RCL1", "RCN1", "RCN2", "RDH13", "RDH14", "RDX", "RECQL", "REEP4", "REEP5", "RER1", "RETREG3", "RETSAT", "REXO4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RFT1", "RHBDD2", "RHOT2", "RIF1", "RINT1", "RMC1", "RMDN1", "RMDN3", "RMND1", "RNASEH2A", "RNF14", "RNF20", "RNF219", "RNF40", "RNH1", "RNPEP", "RPA1", "RPA2", "RPAP1", "RPAP3", "RPF1", "RPF2", "RPL10", "RPL10A", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL32", "RPL34", "RPL35", "RPL36", "RPL36A", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPN1", "RPN2", "RPP30", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS28", "RPS29", "RPS3", "RPS3A", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPSA", "RPTOR", "RPUSD3", "RRBP1", "RRM1", "RRM2", "RRP1", "RRP12", "RRP15", "RRP1B", "RRP36", "RRP8", "RRP9", "RRS1", "RSL1D1", "RSL24D1", "RSU1", "RTCB", "RTN2", "RTN3", "RTN4", "RTRAF", "RUFY1", "RUVBL1", "RUVBL2", "S100A11", "S100A13", "SAAL1", "SACM1L", "SAE1", "SAFB", "SAFB2", "SAMD4B", "SAMHD1", "SAMM50", "SAP18", "SAR1A", "SARM1", "SARNP", "SARS", "SARS2", "SART1", "SART3", "SBDS", "SCAF1", "SCAF4", "SCAMP1", "SCAMP2", "SCAMP3", "SCARB1", "SCARB2", "SCCPDH", "SCD", "SCML2", "SCO2", "SCP2", "SCPEP1", "SCRIB", "SCRN1", "SDAD1", "SDCBP", "SDF4", "SDHA", "SDHB", "SDR39U1", "SEC11A", "SEC16A", "SEC23A", "SEC23B", "SEC23IP", "SEC24A", "SEC24B", "SEC24C", "SEC24D", "SEC31A", "SEC61A1", "SEC61B", "SEC62", "SEC63", "SENP3", "SEPHS1", "SEPT11", "SEPT2", "SEPT6", "SEPT7", "SEPT9", "SERBP1", "SERPINB6", "SERPINH1", "SET", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFXN1", "SFXN2", "SFXN4", "SGPL1", "SGTA", "SH3GL1", "SH3GLB1", "SH3GLB2", "SHMT1", "SHMT2", "SIN3A", "SIRT1", "SKIV2L", "SKIV2L2", "SKP1", "SKP2", "SLC16A1", "SLC19A1", "SLC1A5", "SLC25A10", "SLC25A12", "SLC25A13", "SLC25A17", "SLC25A19", "SLC25A20", "SLC25A22", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A4", "SLC25A42", "SLC25A5", "SLC25A6", "SLC27A4", "SLC30A5", "SLC30A6", "SLC33A1", "SLC35B2", "SLC35F2", "SLC39A14", "SLC3A2", "SLC4A1AP", "SLC4A7", "SLC6A15", "SLC9A3R1", "SLFN11", "SLIRP", "SLK", "SLTM", "SMAP1", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC6", "SMG5", "SMN1*", "SMNDC1", "SMPD4", "SMS", "SMU1", "SMYD3", "SNAP23", "SND1", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPC", "SNRPD2", "SNRPD3", "SNW1", "SNX1", "SNX17", "SNX19", "SNX2", "SNX27", "SNX5", "SNX6", "SNX9", "SOAT1", "SOD2", "SON", "SORD", "SPAG9", "SPART", "SPATA5", "SPATA5L1", "SPC24", "SPC25", "SPCS2", "SPECC1L", "SPEN", "SPHK2", "SPNS1", "SPR", "SPTAN1", "SPTBN1", "SPTBN2", "SPTLC1", "SQLE", "SQSTM1", "SRCAP", "SREK1", "SRI", "SRM", "SRP14", "SRP54", "SRP68", "SRPK1", "SRPK2", "SRPRB", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF3", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSR1", "SSR4", "SSRP1", "STAG1", "STAG2", "STAM", "STAMBP", "STARD3", "STARD3NL", "STARD7", "STAT1", "STAT3", "STAU1", "STAU2", "STIM1", "STIP1", "STK26", "STK4", "STMN1", "STOM", "STOML2", "STRAP", "STRN", "STT3B", "STX10", "STX12", "STX18", "STX3", "STX4", "STX5", "STX7", "STX8", "STXBP3", "STXBP4", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGP2", "SUGT1", "SUN1", "SUN2", "SUPT16H", "SUPT5H", "SUPT6H", "SUPV3L1", "SURF4", "SURF6", "SUZ12", "SV2A", "SYAP1", "SYMPK", "SYNCRIP", "SYNE2", "SYNGR2", "SYNJ2BP", "TAB1", "TACC3", "TADA3", "TAF15", "TAF6L", "TAGLN2", "TALDO1", "TAOK1", "TAP1", "TARDBP", "TARS", "TARS2", "TBC1D13", "TBC1D15", "TBC1D2B", "TBC1D4", "TBC1D9B", "TBCA", "TBCB", "TBL2", "TBL3", "TBRG4", "TCAF1", "TCEA1", "TCERG1", "TCOF1", "TDRKH", "TECR", "TELO2", "TERF2IP", "TES", "TEX10", "TEX264", "TFAM", "TFCP2", "TFG", "TFIP11", "TFRC", "TGOLN2", "THOC1", "THOC2", "THOC3", "THOC5", "THOC6", "THOP1", "THRAP3", "THUMPD1", "THUMPD3", "THYN1", "TIA1", "TIAL1", "TIGAR", "TIMELESS", "TIMM10", "TIMM13", "TIMM17A", "TIMM17B", "TIMM23", "TIMM44", "TIMM50", "TIMM9", "TIPRL", "TJP1", "TKT", "TLN1", "TM9SF3", "TMA16", "TMCO1", "TMED10", "TMED2", "TMEM109", "TMEM126A", "TMEM126B", "TMEM165", "TMEM167A", "TMEM192", "TMEM201", "TMEM205", "TMEM209", "TMEM214", "TMEM230", "TMEM259", "TMEM87A", "TMEM97", "TMF1", "TMOD3", "TMPPE", "TMX1", "TMX2", "TMX4", "TNKS1BP1", "TNPO1", "TNPO2", "TNPO3", "TOE1", "TOMM20", "TOMM22", "TOMM34", "TOMM40", "TOMM5", "TOMM70", "TOP1", "TOP2A", "TOP2B", "TOR1AIP1", "TOR1B", "TOX4", "TP53", "TP53I11", "TPD52", "TPD52L2", "TPI1", "TPM1", "TPM3", "TPM4", "TPP2", "TPR", "TPT1", "TPX2", "TRA2A", "TRA2B", "TRABD", "TRAF2", "TRAP1", "TRAPPC5", "TRIM21", "TRIM25", "TRIM28", "TRIM33", "TRIP12", "TRIP13", "TRIR", "TRMT10C", "TRMT11", "TRMT1L", "TRMT2A", "TRMU", "TROVE2", "TRRAP", "TRUB1", "TSFM", "TSG101", "TSN", "TSNAX", "TSPAN3", "TSPAN6", "TSR1", "TST", "TTC1", "TTC19", "TTC37", "TTC38", "TTC4", "TTK", "TTLL12", "TUBB", "TUBB2A", "TUBB2B", "TUBB3", "TUBB4B", "TUBB6", "TUBGCP2", "TUBGCP4", "TUFM", "TWF1", "TWF2", "TWISTNB", "TXLNA", "TXLNG", "TXNDC5", "TXNDC9", "TXNL1", "TXNRD1", "U2AF1", "U2AF2", "U2SURP", "UAP1", "UBA1", "UBA2", "UBA3", "UBA6", "UBAC1", "UBAP2L", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2O", "UBE2S", "UBE3A", "UBE4A", "UBLCP1", "UBP1", "UBQLN2", "UBQLN4", "UBR4", "UBR5", "UBTF", "UBXN1", "UBXN4", "UBXN7", "UCHL5", "UCK2", "UFC1", "UFD1", "UFL1", "UGGT1", "UGP2", "UGT8", "UHRF1", "UMPS", "UNC45A", "UNG", "UPF1", "UQCC2", "UQCRC1", "UQCRC2", "UQCRQ", "URB1", "UROD", "USO1", "USP10", "USP11", "USP14", "USP28", "USP36", "USP39", "USP47", "USP48", "USP5", "USP7", "USP9X", "UTP11", "UTP14A", "UTP15", "UTP18", "UTP20", "UTP3", "UTP4", "UTP6", "UTRN", "UXT", "VAMP7", "VANGL1", "VAPA", "VAPB", "VARS1", "VBP1", "VCL", "VCP", "VDAC2", "VDAC3", "VIM", "VIRMA", "VKORC1L1", "VMP1", "VPS13D", "VPS26A", "VPS29", "VPS33A", "VPS35", "VPS4A", "VPS4B", "VPS51", "VPS53", "VRK1", "VRK3", "WAPL", "WARS", "WASHC5", "WBP11", "WBP2", "WDHD1", "WDR1", "WDR11", "WDR12", "WDR18", "WDR26", "WDR3", "WDR34", "WDR36", "WDR41", "WDR46", "WDR48", "WDR5", "WDR6", "WDR61", "WDR70", "WDR77", "WDR82", "WIPI2", "WIZ", "WLS", "XAB2", "XPNPEP1", "XPNPEP3", "XPO1", "XPO4", "XPO5", "XPOT", "XRCC1", "XRCC5", "XRCC6", "XRN2", "YARS", "YARS2", "YBX1", "YBX3", "YIF1A", "YIPF3", "YIPF4", "YIPF5", "YKT6", "YLPM1", "YME1L1", "YRDC", "YTHDC1", "YTHDC2", "YWHAB", "YWHAE", "YWHAG", "YWHAQ", "ZADH2", "ZC3H11A", "ZC3H14", "ZC3H15", "ZC3H18", "ZC3HAV1", "ZC3HC1", "ZCCHC3", "ZDHHC13", "ZFR", "ZFYVE16", "ZMYM2", "ZNF207", "ZNF280C", "ZNF281", "ZNF318", "ZNF326", "ZNF512", "ZNF512B", "ZNF622", "ZNF638", "ZPR1", "ZRANB2", "ZW10", "ZWINT", "ZYX"], "leading_proteins": ["AARS2", "ABCB7", "ABCC1", "ABHD10", "ACOX1", "ACOX3", "AGK", "AGPAT5", "AGPS", "AIFM1", "ALDH3A2", "ALDH5A1", "ALG1", "ALG12", "ANKLE2", "APOO", "APOOL", "ARL1", "ARL6IP1", "ARL6IP6", "ATAD1", "ATAD3A", "ATAD3B", "ATL2", "ATP5F1", "ATP5I", "ATP5L", "ATP6V0A1", "ATP7B", "ATPAF1", "BCAP31", "BCL2L13", "BNIP1", "BRI3BP", "BSDC1", "C12orf73", "C16orf58", "C19orf70", "C1QBP", "CALU", "CANX", "CCDC47", "CDIPT", "CDS2", "CERS1", "CERS2", "CETN2", "CHCHD3", "CHST14", "CISD1", "CLCC1", "CLPP", "CLPTM1", "CLPTM1L", "COA3", "COMT", "COQ8A", "COQ9", "COX4I1", "CPT2", "CYB5B", "CYB5D2", "CYC1", "CYP20A1", "CYP51A1", "DARS2", "DDX28", "DEGS1", "DERL1", "DERL2", "DHCR7", "DHFR", "DHRS7", "DIABLO", "DLD", "DNAJC1", "EFCAB14", "EMD", "ENDOD1", "ERGIC2", "ERLIN1", "FAM162A", "FAM210A", "FDFT1", "FKBP10", "FKBP14", "FKBP7", "FKBP9", "FLOT1", "FOXRED1", "GADD45GIP1", "GALNT4", "GHITM", "GLB1", "GLUD1", "GOLIM4", "GOLPH3", "GPAA1", "GPR107", "HACD3", "HADH", "HADHA", "HAUS3", "HCCS", "HINT3", "HK2", "HLA-A", "HMOX1", "HS2ST1", "HSDL1", "HSDL2", "HSPA9", "HTRA2", "IKBIP", "ILVBL", "IMMT", "IMPAD1", "KDELR1", "KIAA0319L", "KIAA1147", "KIAA2013", "L2HGDH", "LAS1L", "LBR", "LETM1", "LONP1", "LPCAT1", "LRRC59", "MAIP1", "MCCC2", "MCL1", "METTL7A", "METTL9", "MFN1", "MGST2", "MIA2", "MICU2", "MIPEP", "MOSPD2", "MPDU1", "MPP1", "MRPL10", "MRPL50", "MRPS9", "MSMO1", "MTCH2", "MTDH", "MTFP1", "MTX1", "NAA40", "NAMPT", "NCLN", "NDC1", "NDUFA11", "NDUFA13", "NDUFA4", "NDUFA8", "NDUFAF2", "NDUFB1", "NDUFB4", "NDUFB5", "NDUFB6", "NDUFB9", "NLN", "NLRX1", "NNT", "NUCB1", "NUCB2", "NUDT9", "NUF2", "NUP35", "OCIAD1", "OPA1", "OXA1L", "P3H4", "P4HA1", "PDHB", "PECR", "PEX14", "PEX19", "PGRMC1", "PHB", "PHB2", "PI4KB", "PISD", "PITRM1", "PLD3", "PMPCA", "PNPLA6", "POLRMT", "PPT1", "PSMB4", "PTGES2", "PTPMT1", "RBM39", "RCN2", "RDH13", "REEP4", "REEP5", "RER1", "RHBDD2", "RMND1", "RTN3", "RTN4", "SAMM50", "SAR1A", "SCAMP2", "SCARB1", "SCD", "SCO2", "SCPEP1", "SDF4", "SDHB", "SEC11A", "SET", "SFXN1", "SFXN2", "SFXN4", "SGPL1", "SHMT2", "SLC16A1", "SLC25A10", "SLC25A13", "SLC25A17", "SLC25A19", "SLC25A20", "SLC25A22", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A4", "SLC25A42", "SLC25A5", "SLC25A6", "SLC30A5", "SLC30A6", "SLC39A14", "SOAT1", "SPTLC1", "SSR1", "SSR4", "STARD3", "STARD7", "STX10", "STX12", "STX18", "STX5", "STX7", "SUCLG2", "SURF4", "SYNGR2", "SYNJ2BP", "TAP1", "TECR", "TFAM", "TGOLN2", "TIMM13", "TIMM17A", "TIMM17B", "TIMM23", "TIMM44", "TIMM50", "TIMM9", "TM9SF3", "TMEM109", "TMEM126B", "TMEM165", "TMEM192", "TMEM201", "TMEM205", "TMEM209", "TMEM214", "TMEM230", "TMEM259", "TMEM87A", "TMEM97", "TMPPE", "TMX1", "TMX4", "TOMM20", "TOMM22", "TOMM40", "TOMM5", "TPD52", "TRABD", "TRMU", "TSPAN3", "TSPAN6", "TTC19", "TUFM", "UGT8", "UQCC2", "UQCRC1", "UQCRC2", "UQCRQ", "UXT", "VDAC2", "VDAC3", "VKORC1L1", "WLS", "YIF1A", "YIPF3", "YIPF5", "YKT6", "ZADH2", "ZDHHC13"]} \ No newline at end of file