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interpro_active_site/advanced/idx2term.json

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+{}

interpro_active_site/basic/idx2term.json

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+{}

interpro_active_site/consensus.joblib

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+version https://git-lfs.github.com/spec/v1
+oid sha256:d9c9c88a82f31c64aea3b3a08613c5ffbc7187f0e9f9b47b5483703ce1ba90aa
+size 70846

interpro_active_site/df_merge.tsv

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+term	overlap	setsize	score	pval	overlap_mean	setsize_mean	score_mean	pval_mean	overlap_std	setsize_std	score_std	pval_std	pval_hit	pval_50	pval_100	pval_250	pval_500

interpro_active_site/metrics.json

@@ -0,0 +1,7 @@
+{
+    "type_of_task": "ranksum",
+    "signature_size": 2973,
+    "annotations_size": 53,
+    "title": "Average number of proteins per term",
+    "value": 2.547169811320755
+}

interpro_active_site/paths.json

@@ -0,0 +1 @@
+{"results_path": "results/proteins/hek293t_core/interpro_active_site/fragment/C221/C221_val_log2fc"}

interpro_active_site/result.tsv

@@ -0,0 +1,6 @@
+Term	es	nes	pval	sidak	fdr	geneset_size	leading_edge	leading_edge_size
+Cysteine peptidase, cysteine active site [IPR000169]	0.8728191539256963	1.9350501805063416	0.0529841381621252	0.9441614131340794	0.1810474471500315	5	P07858	1
+Cysteine peptidase, histidine active site [IPR025660]	0.9909121507909786	1.8951553564546888	0.0580718226707648	0.9580296291607	0.1810474471500315	2	P07858	1
+Cysteine peptidase, asparagine active site [IPR025661]	0.9909121507909786	1.8951553564546888	0.0580718226707648	0.9580296291607	0.1810474471500315	2	P07858	1
+Serine carboxypeptidase, serine active site [IPR018202]	0.9858585858585855	1.6515445088216008	0.0986274402183542	0.9959268571611032	0.2178022638155322	3	P10619,Q9HB40	2
+Tyrosine-protein kinase, active site [IPR008266]	0.6641360092024673	0.5191791601943953	0.6036358101993187	1.0	0.727106771376452	3	Q15375	1

interpro_active_site/selections.json

@@ -0,0 +1 @@
+{"all_annotations": ["ATP synthase, F0 complex, subunit A, active site [IPR023011]", "ATP-citrate lyase/succinyl-CoA ligase, active site [IPR017440]", "ATP:guanido phosphotransferase active site [IPR022415]", "ATPase, alpha/beta subunit, nucleotide-binding domain, active site [IPR020003]", "Adenylosuccinate synthase,  active site [IPR033128]", "Beta-ketoacyl synthase, active site [IPR018201]", "Citrate synthase active site [IPR019810]", "ClpP, Ser active site [IPR018215]", "ClpP, histidine active site [IPR033135]", "Coenzyme A transferase active site [IPR004164]", "Cysteine peptidase, asparagine active site [IPR025661]", "Cysteine peptidase, cysteine active site [IPR000169]", "Cysteine peptidase, histidine active site [IPR025660]", "DNA methylase, C-5 cytosine-specific, active site [IPR018117]", "DNA topoisomerase I, active site [IPR018521]", "Ferrochelatase, active site [IPR019772]", "Glucose-6-phosphate dehydrogenase, active site [IPR019796]", "Glyceraldehyde 3-phosphate dehydrogenase, active site [IPR020830]", "Glycosyl hydrolases family 31, active site [IPR030458]", "Histidine acid phosphatase active site [IPR033379]", "Hydroxymethylglutaryl-CoA lyase, active site [IPR000138]", "Hydroxymethylglutaryl-coenzyme A synthase, active site [IPR000590]", "L-lactate dehydrogenase, active site [IPR018177]", "Leu/Phe/Val dehydrogenases active site [IPR033524]", "Malate dehydrogenase, active site [IPR001252]", "Nucleoside diphosphate kinase, active site [IPR023005]", "Orotidine 5'-phosphate decarboxylase, active site [IPR018089]", "Peptidase S16, active site [IPR008268]", "Peptidase S26A, signal peptidase I, serine active site [IPR019756]", "Peptidase S8, subtilisin, His-active site [IPR022398]", "Peptidase S8, subtilisin, Ser-active site [IPR023828]", "Peptidase S9, serine active site [IPR002471]", "Phosphoglycerate/bisphosphoglycerate mutase, active site [IPR001345]", "Phosphoribosylglycinamide formyltransferase, active site [IPR001555]", "Protein-tyrosine phosphatase, active site [IPR016130]", "Pyridine nucleotide-disulphide oxidoreductase, class I, active site [IPR012999]", "Pyruvate kinase, active site [IPR018209]", "Ribonuclease T2, His active site 1 [IPR018188]", "Ribonuclease T2, His active site 2 [IPR033130]", "Ribonucleotide reductase small subunit, acitve site [IPR030475]", "Serine carboxypeptidase, serine active site [IPR018202]", "Serine carboxypeptidases, histidine active site [IPR033124]", "Serine/threonine-protein kinase, active site [IPR008271]", "Thermonuclease active site [IPR002071]", "Thiolase, active site [IPR020610]", "Thiolase, acyl-enzyme intermediate active site [IPR020615]", "Thymidylate synthase, active site [IPR020940]", "Transaldolase, active site [IPR018225]", "Triosephosphate isomerase, active site [IPR020861]", "Tyrosine-protein kinase, active site [IPR008266]", "Ubiquitin-activating enzyme E1, Cys active site [IPR033127]", "Ubiquitin-conjugating enzyme, active site [IPR023313]", "Uracil-DNA glycosylase, active site [IPR018085]"], "available_proteins": ["ACAA2", "ACAT1", "ACAT2", "ACLY", "ACP2", "ACP6", "ADSS", "AKT2", "APEH", "ARAF", "ATP5A1", "ATP5B", "ATP6", "ATP6V1A", "ATP6V1B2", "AURKA", "AURKB", "BLMH", "CAMK1", "CAMK2G", "CAPN1", "CAPN2", "CDC34", "CDC7", "CDK1", "CDK2", "CDK4", "CDK5", "CDK6", "CKB", "CKMT1A*", "CLPP", "CPVL", "CS", "CSK", "CSNK1A1", "CSNK2A2", "CTSA", "CTSB", "CTSC", "DLD", "DNMT1", "DUSP3", "EIF2AK2", "EPHA7", "FASN", "FECH", "G6PD", "GAA", "GAK", "GANAB", "GAPDH", "GART", "GLUD1", "GSR", "HADHB", "HMGCL", "HMGCS1", "LDHA", "LDHB", "LONP1", "MAP2K2", "MAPK1", "MASTL", "MDH1", "MDH2", "MTMR14", "MTMR2", "NEK9", "NME1", "OXCT1", "PAK2", "PBK", "PGAM1", "PIK3R4", "PKM", "PKMYT1", "PKN1", "PKN2", "PLK1", "PREP", "PRKAA2", "PRKACA", "PRKCB", "PRPF4B", "PTK7", "PTPMT1", "PTPN1", "PTPN11", "PTPRF", "RNASET2", "ROCK1", "RPS6KA1", "RPS6KA3", "RRM2", "SCP2", "SCPEP1", "SEC11A", "SLK", "SND1", "SRPK1", "SRPK2", "SUCLG1", "TALDO1", "TAOK1", "TIGAR", "TOP1", "TPI1", "TPP2", "TTK", "TXNRD1", "TYMS", "UBA1", "UBA2", "UBA3", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2S", "ULK3", "UMPS", "UNG", "VRK1"], "leading_proteins": ["CTSA", "CTSB", "EPHA7", "SCPEP1"]}

interpro_binding_site/advanced/idx2term.json

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+{}

interpro_binding_site/basic/idx2term.json

@@ -0,0 +1 @@
+{"0": "EF-Hand 1, calcium-binding site [IPR018247]"}

interpro_binding_site/consensus.joblib

@@ -0,0 +1,3 @@
+version https://git-lfs.github.com/spec/v1
+oid sha256:805ffff519b0f9aefb1479c0f1ed053909debc160180d0115ea219d35cf7c6b6
+size 67131

interpro_binding_site/df_merge.tsv

@@ -0,0 +1 @@
+term	overlap	setsize	score	pval	overlap_mean	setsize_mean	score_mean	pval_mean	overlap_std	setsize_std	score_std	pval_std	pval_hit	pval_50	pval_100	pval_250	pval_500

interpro_binding_site/metrics.json

@@ -0,0 +1,7 @@
+{
+    "type_of_task": "ranksum",
+    "signature_size": 2973,
+    "annotations_size": 31,
+    "title": "Average number of proteins per term",
+    "value": 4.32258064516129
+}

interpro_binding_site/paths.json

@@ -0,0 +1 @@
+{"results_path": "results/proteins/hek293t_core/interpro_binding_site/fragment/C221/C221_val_log2fc"}

interpro_binding_site/result.tsv

@@ -0,0 +1,5 @@
+Term	es	nes	pval	sidak	fdr	geneset_size	leading_edge	leading_edge_size
+EF-Hand 1, calcium-binding site [IPR018247]	0.5114974999965584	1.6178108048581503	0.1057033771320103	0.9686722421946932	0.4096005863865403	36	Q02818,Q9H4M9,Q96AY3,P0DP25,Q9UBC2,Q14257,P80303,Q9Y680,Q9H223,Q9NWM8,Q9BRK5,Q15293,O43852,P31949	14
+Beta tubulin, autoregulation binding site [IPR013838]	0.5838395325113144	0.9508077790205736	0.3417019629562268	0.9999976498295428	0.7566257751173593	6	Q13509	1
+Peptidase M16, zinc-binding site [IPR001431]	0.4780997304582223	0.4012008078973406	0.6882722859814816	0.9999999999999998	0.9276713419750404	5	Q10713,P22695,O75439,P14735	4
+Aminotransferase, class-II, pyridoxal-phosphate binding site [IPR001917]	0.4601144395826206	0.1327967593747575	0.8943541173053895	1.0	0.990177772730967	2	O15270	1

interpro_binding_site/selections.json

@@ -0,0 +1 @@
+{"all_annotations": ["2-oxo acid dehydrogenase, lipoyl-binding site [IPR003016]", "2Fe-2S ferredoxin, iron-sulphur binding site [IPR006058]", "6-phosphogluconate-binding site [IPR006184]", "AP endonuclease 1, binding site [IPR020847]", "APOBEC/CMP deaminase, zinc-binding [IPR016192]", "Aconitase family, 4Fe-4S cluster binding site [IPR018136]", "Adenylosuccinate synthase, GTP-binding site [IPR018220]", "Aminotransferase class-V, pyridoxal-phosphate binding site [IPR020578]", "Aminotransferase, class-II, pyridoxal-phosphate binding site [IPR001917]", "Aminotransferases, class-I, pyridoxal-phosphate-binding site [IPR004838]", "Beta tubulin, autoregulation binding site [IPR013838]", "Biotin-binding site [IPR001882]", "Coenzyme A transferase binding site [IPR004163]", "Copper centre Cu(A) [IPR001505]", "Cytochrome b5, heme-binding site [IPR018506]", "Cytochrome c oxidase, subunit Vb, zinc binding site [IPR020893]", "EF-Hand 1, calcium-binding site [IPR018247]", "Fumarate reductase/succinate dehydrogenase, FAD-binding site [IPR003952]", "Hexokinase, binding site [IPR019807]", "IQ motif, EF-hand binding site [IPR000048]", "Inositol monophosphatase, metal-binding site [IPR020583]", "Manganese/iron superoxide dismutase, binding site [IPR019833]", "PPM-type phosphatase, divalent cation binding [IPR000222]", "Peptidase M16, zinc-binding site [IPR001431]", "Peptidase M24A, methionine aminopeptidase, subfamily 2, binding site [IPR018349]", "Porphobilinogen deaminase, dipyrromethane cofactor binding site [IPR022419]", "Protein kinase, ATP binding site [IPR017441]", "RNA polymerases, subunit N, zinc binding site [IPR020789]", "Serine hydroxymethyltransferase, pyridoxal phosphate binding site [IPR019798]", "Sigma-54 interaction domain, ATP-binding site 1 [IPR025662]", "Transketolase binding site [IPR020826]"], "available_proteins": ["ACACA", "ACO1", "ACO2", "ACTN1", "ACTN4", "ADSS", "AKT2", "APEX1", "ARAF", "AURKA", "AURKB", "BPNT1", "CALM3", "CALU", "CAMK1", "CAMK2G", "CAPN1", "CAPN2", "CDC7", "CDK1", "CDK2", "CDK4", "CDK5", "CDK6", "CETN2", "COX2", "COX5B", "CSK", "CSNK1A1", "CSNK2A2", "CYB5B", "DBT", "DCTD", "DLAT", "DLST", "DST", "EHD1", "EHD4", "EIF2AK2", "EPHA7", "EPS15L1", "FKBP10", "FKBP14", "FKBP7", "FKBP9", "GCAT", "GOT1", "GOT2", "GPD2", "HK1", "HK2", "HMBS", "IDE", "ILKAP", "IMPA1", "IQGAP1", "IQGAP2", "LETM1", "MACF1", "MAP2K2", "MAPK1", "MAPK14", "MCCC1", "METAP2", "MICU1", "MYH10", "MYH9", "MYO1B", "MYO1C", "MYO1D", "NRDC", "NUCB1", "NUCB2", "OXCT1", "OXSR1", "PA2G4", "PAK2", "PC", "PCCA", "PDCD6", "PEF1", "PGD", "PKMYT1", "PKN1", "PKN2", "PLCG1", "PLK1", "PLS3", "PMPCA", "PMPCB", "POLR2L", "PPM1G", "PRKAA2", "PRKACA", "PRKCB", "PRKCSH", "PSAT1", "RAB18", "RCN1", "RCN2", "RHOT1", "RHOT2", "ROCK1", "RPS6KA1", "RPS6KA3", "S100A11", "SDF4", "SDHA", "SDHB", "SHMT1", "SHMT2", "SLC25A12", "SLC25A24", "SLK", "SOD2", "SPTAN1", "SPTLC2", "SRI", "SRPK1", "SRPK2", "STK26", "STK4", "TAOK1", "TKT", "TTK", "TUBB", "TUBB2A", "TUBB2B", "TUBB3", "TUBB4B", "TUBB6", "ULK3", "UQCRC2", "VRK1"], "leading_proteins": ["CALM3", "CALU", "EHD1", "EHD4", "EPS15L1", "FKBP10", "FKBP14", "FKBP7", "IDE", "NUCB1", "NUCB2", "PMPCA", "PMPCB", "RCN1", "RCN2", "S100A11", "SDF4", "SPTLC2", "TUBB3", "UQCRC2"]}

interpro_conserved_site/advanced/idx2term.json

@@ -0,0 +1 @@
+{}

interpro_conserved_site/basic/idx2term.json

@@ -0,0 +1 @@
+{}

interpro_conserved_site/consensus.joblib

@@ -0,0 +1,3 @@
+version https://git-lfs.github.com/spec/v1
+oid sha256:9097ff3c4fff67664d480dbd91d1caea8651e06d0dcdb664485eb45847b1949f
+size 89702

interpro_conserved_site/df_merge.tsv

@@ -0,0 +1,2 @@
+term	overlap	setsize	score	pval	overlap_mean	setsize_mean	score_mean	pval_mean	overlap_std	setsize_std	score_std	pval_std	pval_hit	pval_50	pval_100	pval_250	pval_500
+Aldehyde dehydrogenase, cysteine active site [IPR016160]	2	7	2.167226629385421	0.0302175778386351	2.478155339805826	7.286407766990291	-0.1163447967243902	0.4155558234730984	1.8026432844079276	0.5916159446457568	1.150914295148441	0.2845969995849257	0.0021566506862559	0.0308605386172727	0.0750276850021153	0.0012927063187422	0.0113426595185519

interpro_conserved_site/metrics.json

@@ -0,0 +1,7 @@
+{
+    "type_of_task": "ranksum",
+    "signature_size": 2973,
+    "annotations_size": 270,
+    "title": "Average number of proteins per term",
+    "value": 2.6259259259259258
+}

interpro_conserved_site/paths.json

@@ -0,0 +1 @@
+{"results_path": "results/proteins/hek293t_core/interpro_conserved_site/fragment/C221/C221_val_log2fc"}

interpro_conserved_site/result.tsv

@@ -0,0 +1,44 @@
+Term	es	nes	pval	sidak	fdr	geneset_size	leading_edge	leading_edge_size
+Aldehyde dehydrogenase, cysteine active site [IPR016160]	0.843470788386214	2.167226629385421	0.0302175778386351	0.999747615216856	0.2003951185579891	7	P51649,P05091	2
+Annexin repeat, conserved site [IPR018252]	0.7897153223101487	1.943650107687729	0.0519376589472724	0.9999994428631506	0.2260645952160202	7	P04083	1
+Amyloidogenic glycoprotein, intracellular domain, conserved site [IPR019745]	0.994614607876136	1.9102773641565869	0.0560975106647161	0.9999998300483088	0.2260645952160202	2	P05067	1
+Amyloidogenic glycoprotein,  copper-binding domain conserved site [IPR019744]	0.994614607876136	1.9102773641565869	0.0560975106647161	0.9999998300483088	0.2260645952160202	2	P05067	1
+Proteinase inhibitor I2, Kunitz, conserved site [IPR020901]	0.994614607876136	1.9102773641565869	0.0560975106647161	0.9999998300483088	0.2260645952160202	2	P05067	1
+Glycoside hydrolase, family 29, conserved site [IPR018526]	0.9882194547290472	1.884150862671104	0.0595445719275788	0.9999999367123884	0.2319146203426278	2	P04066	1
+Low-density lipoprotein (LDL) receptor class A, conserved site [IPR023415]	0.9818243015819584	1.8579934638835884	0.0631699424930156	0.9999999776940665	0.2326345573831171	2	Q9NPF0	1
+Lysosome-associated membrane glycoprotein, conserved site [IPR018134]	0.9808145405587338	1.8538606353333924	0.0637591009124098	0.9999999811784904	0.2326345573831171	2	P13473	1
+EGF-like calcium-binding, conserved site [IPR018097]	0.96667788623359	1.795928644106247	0.0725058662009288	0.9999999985071496	0.2416463078483414	2	Q07954	1
+C-type lectin, conserved site [IPR018378]	0.965331538202624	1.7904046789499086	0.0733888786798666	0.9999999988456773	0.2416463078483414	2	Q9UBG0	1
+Glycoside hydrolase family 27/36, conserved site [IPR000111]	0.9461460787613556	1.7115806496017754	0.0869739768473354	0.999999999978598	0.2730578342881461	2	P06280	1
+Chromo domain, conserved site [IPR023779]	0.7874170693595507	1.5969111107766216	0.1102855227552901	0.99999999999998	0.3185064412026068	5	P83916,Q13185,O14646	3
+Immunoglobulin/major histocompatibility complex, conserved site [IPR003006]	0.9690235690235682	1.589515782072467	0.1119439938565345	0.999999999999988	0.3185064412026068	3	P04439,P55899	2
+Tetraspanin, conserved site [IPR018503]	0.966329966329968	1.5795820069984716	0.1142026224995644	0.999999999999994	0.3211948757800251	3	O43657,O60637	2
+Sterol reductase, conserved site [IPR018083]	0.9094580949175308	1.5604657601197522	0.1186498552582511	0.9999999999999984	0.330262483708534	2	Q9UBM7	1
+Cadherin conserved site [IPR020894]	0.9572390572390564	1.546040740978816	0.122094728826009	0.9999999999999994	0.3363834365614534	3	Q14574,P19022	2
+Syntaxin/epimorphin, conserved site [IPR006012]	0.6887137184056936	1.5096069554744769	0.131143745503065	1.0	0.3521302882197343	7	Q13277,Q86Y82,Q12846,O60499	4
+Ubiquitin interacting motif [IPR003903]	0.8929190975523796	1.3086296151820718	0.1906598441219911	1.0	0.4464911872977233	3	O14964	1
+AT hook, DNA-binding motif [IPR017956]	0.8303601480982792	1.235481865407851	0.2166512215256382	1.0	0.4834360741207968	2	Q6ZRS2	1
+Tubulin, conserved site [IPR017975]	0.5838395325113144	0.9508077790205736	0.3417019629562268	1.0	0.572003272962263	6	Q13509	1
+Inositol monophosphatase, conserved site [IPR020550]	0.7900851151396139	0.9352645252272436	0.3496519925079735	1.0	0.572003272962263	3	Q9NX62	1
+Polyamine biosynthesis domain, conserved site [IPR030373]	0.729047458768082	0.8338571870400153	0.4043614652388108	1.0	0.6099307017568654	2	P52788	1
+Aldehyde dehydrogenase, glutamic acid active site [IPR029510]	0.5081538046653347	0.715808466230548	0.4741096240234834	1.0	0.6717898995708506	7	P51649,P05091	2
+Bromodomain, conserved site [IPR018359]	0.491589637811589	0.6457772371571863	0.5184236317257178	1.0	0.6998719028297191	7	P25440,Q9NRL2,Q86U86	3
+Cyclic nucleotide-binding, conserved site [IPR018488]	0.6718276674520255	0.6255949421530178	0.5315806571217248	1.0	0.7140635692679884	2	P10644	1
+Quinone oxidoreductase/zeta-crystallin, conserved site [IPR002364]	0.6952861952862114	0.6148405206732571	0.5386600463395614	1.0	0.7179823163595453	3	Q8N4Q0,Q99536	2
+Oxysterol-binding protein, conserved site [IPR018494]	0.5326553472507918	0.5878794151821236	0.5566132342285719	1.0	0.7331003572766557	5	Q9H4L5	1
+Vinculin, conserved site [IPR000633]	0.6236957253449915	0.4687551563192341	0.6392446569409909	1.0	0.8004820642487998	2	P18206	1
+Dynamin, GTPase region, conserved site [IPR019762]	0.5799394143385965	0.3460556818215944	0.7293008687989277	1.0	0.8673537079181466	2	O00429	1
+Translation elongation factor EF1B, beta/delta chains, conserved site [IPR001326]	0.5456075395489566	0.2657595064568568	0.7904244311632913	1.0	0.8966999849331455	2	P24534	1
+Heat shock protein 70, conserved site [IPR018181]	0.3699335155746465	0.236887621029716	0.8127439736871676	1.0	0.9131884996787932	10	P48723	1
+Intermediate filament protein, conserved site [IPR018039]	0.3775510268820693	0.2292533990301012	0.8186719711134998	1.0	0.9131884996787932	8	P02545,P08670	2
+Ribosomal S11, conserved site [IPR018102]	0.5264220801077024	0.2275623077053963	0.8199865252329399	1.0	0.9131884996787932	2	P82912	1
+Ribosomal RNA adenine methylase transferase, conserved site [IPR020596]	0.5223830360147944	0.220145697022621	0.8257576865859793	1.0	0.9137482597467804	2	Q9UNQ2	1
+Haem oxygenase conserved site [IPR018207]	0.5092561427128823	0.1975460998522961	0.8434002096636377	1.0	0.9219354518590372	2	P30519	1
+RNA polymerase, beta subunit, conserved site [IPR007121]	0.4897340962638812	0.1681519491234903	0.8664637416384717	1.0	0.9433274606547878	2	Q9H9Y6	1
+Proteasome beta-type subunit, conserved site [IPR016050]	0.3527648520873958	0.1508481597133988	0.8800954949522222	1.0	0.949485691545263	8	P20618,P28070	2
+Ras GTPase-activating protein, conserved site [IPR023152]	0.4375631100639504	0.1127329678394294	0.9102422632904152	1.0	0.9694176692448976	2	P46940	1
+Guanylate kinase, conserved site [IPR020590]	0.4094891239272126	0.1105531554121076	0.9119706962526076	1.0	0.9694176692448976	4	Q00013,Q9NZW5	2
+Malic enzyme, conserved site [IPR015884]	0.3258162234937731	0.0728834338345929	0.941898876764776	1.0	0.9822220535466768	2	P48163	1
+Calreticulin/calnexin, conserved site [IPR018124]	0.4047138047138059	0.0698527894059967	0.9443108298848129	1.0	0.9822220535466768	3	P27824,P27797	2
+Thioredoxin, conserved site [IPR017937]	0.3039185531195021	0.0434633963176227	0.9653321424448298	1.0	0.9953855734264972	12	Q14554	1
+FERM conserved site [IPR019747]	0.2967105985953001	0.0026994830024872	0.9978461268061198	1.0	1.0	9	Q9Y2J2,P26038	2

interpro_conserved_site/selections.json

@@ -0,0 +1 @@
+{"all_annotations": ["14-3-3 protein, conserved site [IPR023409]", "3-hydroxyacyl-CoA dehydrogenase, conserved site [IPR006180]", "3-hydroxyisobutyrate dehydrogenase-related, conserved site [IPR002204]", "4Fe-4S ferredoxin, iron-sulphur binding, conserved site [IPR017900]", "ABC transporter-like, conserved site [IPR017871]", "AMP-binding, conserved site [IPR020845]", "AP endonuclease 1, conserved site [IPR020848]", "AT hook, DNA-binding motif [IPR017956]", "ATP synthase, F1 complex, gamma subunit conserved site [IPR023632]", "ATP-citrate lyase/succinyl-CoA ligase, conserved site [IPR033847]", "ATP-dependent RNA helicase DEAD-box, conserved site [IPR000629]", "ATPase, AAA-type, conserved site [IPR003960]", "ATPase, OSCP/delta subunit, conserved site [IPR020781]", "Acin1, RNSP1-SAP18 binding (RSB) motif [IPR032552]", "Actin, conserved site [IPR004001]", "Actin/actin-like conserved site [IPR020902]", "Actinin-type actin-binding domain, conserved site [IPR001589]", "Acyl-CoA dehydrogenase, conserved site [IPR006089]", "Acyl-CoA-binding protein, ACBP, conserved site [IPR022408]", "Adenylate kinase, conserved site [IPR033690]", "Alanine dehydrogenase/NAD(P) transhydrogenase, conserved site-1 [IPR008142]", "Alanine dehydrogenase/pyridine nucleotide transhydrogenase, conserved site-2 [IPR008143]", "Alcohol dehydrogenase, zinc-type, conserved site [IPR002328]", "Aldehyde dehydrogenase, cysteine active site [IPR016160]", "Aldehyde dehydrogenase, glutamic acid active site [IPR029510]", "Aldo/keto reductase, conserved site [IPR018170]", "Alpha-D-phosphohexomutase, conserved site [IPR016066]", "Aminoacyl-tRNA synthetase, class I, conserved site [IPR001412]", "Amyloidogenic glycoprotein,  copper-binding domain conserved site [IPR019744]", "Amyloidogenic glycoprotein, intracellular domain, conserved site [IPR019745]", "Annexin repeat, conserved site [IPR018252]", "Apoptosis regulator, Bcl-2, BH1 motif, conserved site [IPR020717]", "Apoptosis regulator, Bcl-2, BH2 motif, conserved site [IPR020726]", "Apoptosis regulator, Bcl-2, BH3 motif, conserved site [IPR020728]", "ArgE/DapE/ACY1/CPG2/YscS, conserved site [IPR001261]", "BUD31/G10-related, conserved site [IPR018230]", "Bacterial Fmu (Sun)/eukaryotic nucleolar NOL1/Nop2p, conserved site [IPR018314]", "Band 7/stomatin-like, conserved site [IPR018080]", "Bromodomain, conserved site [IPR018359]", "C-type lectin, conserved site [IPR018378]", "CAP, conserved site, C-terminal [IPR028417]", "CAP, conserved site, N-terminal [IPR018106]", "CBX family C-terminal motif [IPR033773]", "Cadherin conserved site [IPR020894]", "Calreticulin/calnexin, conserved site [IPR018124]", "Chaperonin Cpn60, conserved site [IPR018370]", "Chaperonin GroES, conserved site [IPR018369]", "Chaperonin TCP-1, conserved site [IPR002194]", "Chromo domain, conserved site [IPR023779]", "Clathrin adaptor complex, small chain [IPR000804]", "Clathrin adaptor, mu subunit, conserved site [IPR018240]", "Clusterin, conserved site [IPR033986]", "Coproporphyrinogen III oxidase, conserved site [IPR018375]", "Cullin, conserved site [IPR016157]", "Cyclic nucleotide-binding, conserved site [IPR018488]", "Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site [IPR020892]", "Cytochrome P450, conserved site [IPR017972]", "D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site 1 [IPR029752]", "D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site [IPR029753]", "DNA ligase, ATP-dependent, conserved site [IPR016059]", "DNA methylase, C-5 cytosine-specific,  conserved site [IPR031303]", "DNA methylase, N-6 adenine-specific, conserved site [IPR002052]", "DNA mismatch repair, conserved site [IPR014762]", "DNA topoisomerase, type IIA, conserved site [IPR018522]", "DNA-directed DNA polymerase, family B, conserved site [IPR017964]", "DNA-directed RNA polymerase, 14-18kDa subunit, conserved site [IPR020708]", "DNA-directed RNA polymerase, 30-40kDa subunit, conserved site [IPR001514]", "DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site [IPR002464]", "Dihydrofolate reductase conserved site [IPR017925]", "Dihydroorotase, conserved site [IPR002195]", "DnaJ domain, conserved site [IPR018253]", "Dynamin, GTPase region, conserved site [IPR019762]", "Dynein light chain, type 1/2, conserved site [IPR019763]", "EGF-like calcium-binding, conserved site [IPR018097]", "EGF-like, conserved site [IPR013032]", "Electron transfer flavoprotein subunit alpha, conserved site [IPR018206]", "Electron transfer flavoprotein, beta-subunit, conserved site [IPR000049]", "Endonuclease III-like, conserved site-2 [IPR004036]", "Endonuclease III-like, iron-sulphur cluster loop motif [IPR003651]", "Enolase, conserved site [IPR020809]", "Enoyl-CoA hydratase/isomerase, conserved site [IPR018376]", "Ependymin, conserved site [IPR018224]", "Eukaryotic translation initiation factor 4E (eIF-4E), conserved site [IPR019770]", "F-actin capping protein, alpha subunit, conserved site [IPR017865]", "F-actin capping protein, beta subunit, conserved site [IPR019771]", "FERM conserved site [IPR019747]", "FLAP/GST2/LTC4S, conserved site [IPR018295]", "Fatty acid desaturase type 1, conserved site [IPR001522]", "Ferritin, conserved site [IPR014034]", "Fibrillarin, conserved site [IPR020813]", "Formate-tetrahydrofolate ligase, FTHFS, conserved site [IPR020628]", "Fructose-bisphosphate aldolase class-I active site [IPR029768]", "Fumarate lyase, conserved site [IPR020557]", "GHMP kinase, ATP-binding, conserved site [IPR006203]", "GTP1/OBG, conserved site [IPR006074]", "Galactokinase, conserved site [IPR019741]", "Gamma-glutamyl phosphate reductase GPR, conserved site [IPR020593]", "Glucosamine-6-phosphate isomerase, conserved site [IPR018321]", "Glutamate 5-kinase, conserved site [IPR019797]", "Glycoside hydrolase family 27/36, conserved site [IPR000111]", "Glycoside hydrolase, family 29, conserved site [IPR018526]", "Glycoside hydrolase, family 35, conserved site [IPR019801]", "Glycosyl hydrolases family 31, conserved site [IPR030459]", "Glyoxalase I, conserved site [IPR018146]", "Golgin subfamily A member 2, C-terminal binding motif [IPR043937]", "Guanylate kinase, conserved site [IPR020590]", "HIND motif [IPR045347]", "HMG box A DNA-binding domain, conserved site [IPR017967]", "HMG-I/HMG-Y, DNA-binding, conserved site [IPR000637]", "Haem oxygenase conserved site [IPR018207]", "Heat shock protein 70, conserved site [IPR018181]", "Heat shock protein Hsp90, conserved site [IPR019805]", "Heavy-metal-associated, conserved site [IPR017969]", "Helix-hairpin-helix motif [IPR000445]", "Helix-hairpin-helix motif, class 2 [IPR008918]", "Hexapeptide transferase, conserved site [IPR018357]", "Histidine triad, conserved site [IPR019808]", "Histone H2A conserved site [IPR032458]", "Histone H4, conserved site [IPR019809]", "Hydroxymethylglutaryl-CoA reductase, class I/II, conserved site [IPR023076]", "IMP dehydrogenase / GMP reductase, conserved site [IPR015875]", "Immunoglobulin/major histocompatibility complex, conserved site [IPR003006]", "Inositol monophosphatase, conserved site [IPR020550]", "Intermediate filament protein, conserved site [IPR018039]", "Isocitrate/isopropylmalate dehydrogenase, conserved site [IPR019818]", "Kinesin motor domain, conserved site [IPR019821]", "Lipocalin family conserved site [IPR022272]", "Low-density lipoprotein (LDL) receptor class A, conserved site [IPR023415]", "Lysophospholipase patatin, conserved site [IPR001423]", "Lysosome-associated membrane glycoprotein, conserved site [IPR018134]", "Macrophage migration inhibitory factor, conserved site [IPR019829]", "Malic enzyme, conserved site [IPR015884]", "Methylthiotransferase, conserved site [IPR020612]", "Mini-chromosome maintenance, conserved site [IPR018525]", "Mitogen-activated protein (MAP) kinase, conserved site [IPR003527]", "Molybdenum cofactor biosynthesis, conserved site [IPR008284]", "Mrp, conserved site [IPR000808]", "Myristoyl-CoA:protein N-myristoyltransferase, conserved site [IPR022678]", "NADH:ubiquinone oxidoreductase, 30kDa subunit, conserved site [IPR020396]", "NADH:ubiquinone oxidoreductase, 49kDa subunit, conserved site [IPR014029]", "NADH:ubiquinone oxidoreductase, 51kDa subunit, conserved site [IPR001949]", "NADH:ubiquinone oxidoreductase, 75kDa subunit, conserved site [IPR000283]", "NADH:ubiquinone oxidoreductase, subunit 1, conserved site [IPR018086]", "NUDIX hydrolase, conserved site [IPR020084]", "Oxysterol-binding protein, conserved site [IPR018494]", "P-type trefoil, conserved site [IPR017957]", "Peptidase M22, conserved site [IPR017860]", "Peptidase M24B, X-Pro dipeptidase/aminopeptidase P, conserved site [IPR001131]", "Peptidase S26A, signal peptidase I, conserved site [IPR019758]", "Phosphatidylethanolamine-binding, conserved site [IPR001858]", "Phosphatidylinositol 3/4-kinase, conserved site [IPR018936]", "Phosphoenolpyruvate carboxykinase, GTP-utilising, conserved site [IPR018091]", "Phosphofructokinase, conserved site [IPR015912]", "Phosphoglucose isomerase, conserved site [IPR018189]", "Phosphoglycerate kinase, conserved site [IPR015911]", "Phosphomannose isomerase, type I, conserved site [IPR018050]", "Phosphoribosylglycinamide synthetase, conserved site [IPR020559]", "Phosphorylase pyridoxal-phosphate attachment site [IPR035090]", "Polyamine biosynthesis domain, conserved site [IPR030373]", "Polyprenyl synthetase, conserved site [IPR033749]", "Procollagen-lysine 5-dioxygenase, conserved site [IPR001006]", "Profilin conserved site [IPR027310]", "Proliferating cell nuclear antigen, PCNA, conserved site [IPR022659]", "Proteasome beta-type subunit, conserved site [IPR016050]", "Protein phosphatase 2A regulatory subunit PR55, conserved site [IPR018067]", "Proteinase inhibitor I2, Kunitz, conserved site [IPR020901]", "Proteinase inhibitor I25, cystatin, conserved site [IPR018073]", "Pseudouridine synthase TruD, conserved site [IPR020119]", "Purine phosphorylase, family 2, conserved site [IPR018099]", "Quinone oxidoreductase/zeta-crystallin, conserved site [IPR002364]", "RNA 3'-terminal phosphate cyclase-like, conserved site [IPR020719]", "RNA polymerase, beta subunit, conserved site [IPR007121]", "RNA polymerase, subunit H/Rpb5, conserved site [IPR020608]", "Ras GTPase-activating protein, conserved site [IPR023152]", "Retro-transposon transporting motif [IPR018892]", "Ribonuclease II/R, conserved site [IPR022966]", "Ribosomal RNA adenine methylase transferase, conserved site [IPR020596]", "Ribosomal S11, conserved site [IPR018102]", "Ribosomal S24e conserved site [IPR018098]", "Ribosomal protein L1, conserved site [IPR023673]", "Ribosomal protein L10e, conserved site [IPR018255]", "Ribosomal protein L11, conserved site [IPR020785]", "Ribosomal protein L13, conserved site [IPR023563]", "Ribosomal protein L13e, conserved site [IPR018256]", "Ribosomal protein L14P,  conserved site [IPR019972]", "Ribosomal protein L15, conserved site [IPR001196]", "Ribosomal protein L15e, conserved site [IPR020925]", "Ribosomal protein L18e, conserved site [IPR021132]", "Ribosomal protein L19/L19e conserved site [IPR023638]", "Ribosomal protein L2, conserved site [IPR022671]", "Ribosomal protein L21e, conserved site [IPR018259]", "Ribosomal protein L22/L17, conserved site [IPR018260]", "Ribosomal protein L23/L25, conserved site [IPR001014]", "Ribosomal protein L24/L26, conserved site [IPR005825]", "Ribosomal protein L24e, conserved site [IPR023442]", "Ribosomal protein L27e, conserved site [IPR018262]", "Ribosomal protein L29, conserved site [IPR018254]", "Ribosomal protein L3, conserved site [IPR019926]", "Ribosomal protein L30, conserved site [IPR018038]", "Ribosomal protein L30e, conserved site [IPR022991]", "Ribosomal protein L31e, conserved site [IPR020052]", "Ribosomal protein L32e, conserved site [IPR018263]", "Ribosomal protein L34e, conserved site [IPR018065]", "Ribosomal protein L35Ae, conserved site [IPR018266]", "Ribosomal protein L37e, conserved site [IPR018267]", "Ribosomal protein L4/L1e, eukaryotic/archaeal, conserved site [IPR013000]", "Ribosomal protein L5, conserved site [IPR020929]", "Ribosomal protein L6, conserved site-2 [IPR002359]", "Ribosomal protein L7Ae conserved site [IPR004037]", "Ribosomal protein S10, conserved site [IPR018268]", "Ribosomal protein S13, conserved site [IPR018269]", "Ribosomal protein S14, conserved site [IPR018271]", "Ribosomal protein S17, conserved site [IPR019979]", "Ribosomal protein S17e, conserved site [IPR018273]", "Ribosomal protein S19e, conserved site [IPR018277]", "Ribosomal protein S2, conserved site [IPR018130]", "Ribosomal protein S21e, conserved site [IPR018279]", "Ribosomal protein S28e conserved site [IPR028626]", "Ribosomal protein S3, conserved site [IPR018280]", "Ribosomal protein S3Ae, conserved site [IPR018281]", "Ribosomal protein S4, conserved site [IPR018079]", "Ribosomal protein S4e, N-terminal, conserved site [IPR018199]", "Ribosomal protein S5, N-terminal, conserved site [IPR018192]", "Ribosomal protein S6e, conserved site [IPR018282]", "Ribosomal protein S7, conserved site [IPR020606]", "Ribosomal protein S8e, conserved site [IPR018283]", "Ribosomal protein S9, conserved site [IPR020574]", "Ribosome maturation protein SBDS, conserved site [IPR018023]", "RidA, conserved site [IPR019897]", "S-adenosyl-L-homocysteine hydrolase, conserved site [IPR020082]", "S-adenosylmethionine synthetase, conserved site [IPR022631]", "S100/Calbindin-D9k, conserved site [IPR001751]", "SAICAR synthetase, conserved site [IPR018236]", "SecY conserved site [IPR030659]", "Serpin, conserved site [IPR023795]", "Short-chain dehydrogenase/reductase, conserved site [IPR020904]", "Sodium:dicarboxylate symporter, conserved site [IPR018107]", "Squalene/phytoene synthase, conserved site [IPR019845]", "Stathmin, conserved site [IPR030514]", "Sterol reductase, conserved site [IPR018083]", "Succinyl-CoA synthetase, beta subunit, conserved site [IPR017866]", "Sugar transporter, conserved site [IPR005829]", "Sulfatase, conserved site [IPR024607]", "Syntaxin/epimorphin, conserved site [IPR006012]", "TPP-binding enzyme, conserved site [IPR000399]", "Terpene synthase, conserved site [IPR002365]", "Tetrahydrofolate dehydrogenase/cyclohydrolase, conserved site [IPR020867]", "Tetraspanin, conserved site [IPR018503]", "Thiolase, conserved site [IPR020613]", "Thioredoxin, conserved site [IPR017937]", "Thiosulphate sulfurtransferase, conserved site [IPR001307]", "Thymidine kinase, conserved site [IPR020633]", "Thymidylate kinase, conserved site [IPR018095]", "Tr-type G domain, conserved site [IPR031157]", "Transcription factor TFIIB, conserved site [IPR023486]", "Translation elongation factor EF1B, beta/delta chains, conserved site [IPR001326]", "Translation elongation factor Ts, conserved site [IPR018101]", "Translationally controlled tumour protein, conserved site [IPR018103]", "Tubulin, conserved site [IPR017975]", "Tyrosine-protein kinase, receptor class V, conserved site [IPR001426]", "UbiE/COQ5 methyltransferase, conserved site [IPR023576]", "Ubiquitin conserved site [IPR019954]", "Ubiquitin interacting motif [IPR003903]", "Ubiquitin specific protease, conserved site [IPR018200]", "Ubiquitin-activating enzyme E1, conserved site [IPR018074]", "Vinculin, conserved site [IPR000633]", "WD40 repeat, conserved site [IPR019775]", "XPG conserved site [IPR019974]", "Zinc finger, PHD-type, conserved site [IPR019786]", "Zinc finger, RING-type, conserved site [IPR017907]"], "available_proteins": ["AAAS", "AAMP", "ABCB1", "ABCB7", "ABCC1", "ABCD3", "ABCE1", "ABCF1", "ABCF2", "ABCF3", "ACAA2", "ACAD9", "ACADM", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACBD5", "ACIN1", "ACLY", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN4", "ACTR1A", "ACTR1B", "ACTR2", "ACTR3", "ADH5", "ADSL", "AFG3L2", "AHCY", "AHCYL1", "AK1", "AK2", "AKR1A1", "AKR1B1", "ALDH18A1", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ANXA1", "ANXA11", "ANXA2", "ANXA3", "ANXA4", "ANXA6", "ANXA7", "AP1M1", "AP1S2", "AP2M1", "AP2S1", "AP3M1", "AP3S1", "APEX1", "APLP2", "APP", "ARIH2", "ATAD1", "ATAD2", "ATP5C1", "ATP5O", "ATP7B", "BAG6", "BAK1", "BAZ1A", "BAZ1B", "BCS1L", "BOP1", "BPNT1", "BRD2", "BUD31", "CAD", "CALR", "CANX", "CAP1", "CAPZA1", "CAPZA2", "CAPZB", "CASK", "CBR1", "CBX1", "CBX3", "CBX5", "CBX8", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD320", "CDC40", "CDH2", "CDKAL1", "CECR2", "CETN2", "CHAF1B", "CHD1", "CHD1L", "CHD4", "CLGN", "CLU", "CMPK1", "CNDP2", "COLEC12", "COPA", "COPZ1", "CORO1B", "CORO1C", "CORO7", "CPOX", "CSTB", "CTBP1", "CTBP2", "CTNNA1", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CWC27", "CYP51A1", "DCAF13", "DCAF7", "DCPS", "DCXR", "DDT", "DDX10", "DDX17", "DDX18", "DDX20", "DDX23", "DDX24", "DDX27", "DDX3X", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX51", "DDX54", "DDX55", "DDX6", "DHCR7", "DHFR", "DHRS4", "DHRS7", "DHRS7B", "DHX15", "DHX16", "DHX29", "DHX30", "DHX36", "DHX38", "DHX40", "DHX57", "DHX8", "DHX9", "DIDO1", "DIMT1", "DIS3", "DLG3", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC2", "DNAJC9", "DNM1L", "DNM2", "DNMT1", "DRG1", "DRG2", "DSC3", "DSG2", "DST", "DTYMK", "DYNLL2", "EARS2", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "EEF1A2", "EEF1B2", "EEF1D", "EEF2", "EIF3I", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4E", "ENO1", "ENO2", "EPB41", "EPB41L2", "EPB41L3", "EPB41L5", "EPDR1", "EPHA7", "EPRS", "ERCC2", "ETFA", "ETFB", "EXO1", "EZR", "FARP1", "FBL", "FCGRT", "FDFT1", "FDPS", "FEN1", "FH", "FLNA", "FLNB", "FLNC", "FTL", "FUCA1", "FUCA2", "GAA", "GALK1", "GANAB", "GART", "GCDH", "GEMIN5", "GFM1", "GGPS1", "GLA", "GLB1", "GLO1", "GMPPB", "GNPDA1", "GNS", "GOLGA2", "GPHN", "GPI", "GRHPR", "GRWD1", "GSPT1", "GTF2B", "GTF3C2", "GUF1", "H2AFX", "H4C1*", "HADH", "HADHA", "HADHB", "HGS", "HIBADH", "HINT2", "HLA-A", "HLA-B", "HLTF", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMGCR", "HMOX1", "HMOX2", "HSD17B10", "HSD17B12", "HSD17B4", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA13", "HSPA14", "HSPA1B", "HSPA2", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPD1", "HSPE1", "HSPH1", "HYOU1", "IARS", "IARS2", "IDH1", "IDH2", "IDH3A", "IDH3B", "ILVBL", "IMPA1", "IMPAD1", "IMPDH1", "IMPDH2", "INA", "IQGAP1", "IQGAP2", "IVD", "KDM2A", "KDSR", "KIF11", "KIF14", "KIF18B", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF4A", "KIF5B", "KIFC1", "LAMP1", "LAMP2", "LARS", "LARS2", "LBR", "LIG1", "LIG3", "LMNA", "LMNB1", "LMNB2", "LRP1", "LRWD1", "LSS", "MACF1", "MAPK1", "MAPK14", "MARS", "MAT2A", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "ME1", "ME2", "MGST2", "MIF", "MKRN2", "MPI", "MPP1", "MPP6", "MPST", "MRC2", "MRPL24", "MRPL3", "MRPS11", "MRPS5", "MRPS9", "MSN", "MTAP", "MTHFD1", "MTHFD1L", "MTHFD2", "MTOR", "MVK", "NAGA", "ND1", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS8", "NDUFV1", "NEFL", "NEFM", "NES", "NKTR", "NLE1", "NMT1", "NNT", "NOP2", "NSD2", "NSF", "NTHL1", "NUBP2", "NUBPL", "NUDT1", "NUDT5", "NUP153", "NUP37", "NUP43", "NVL", "OSBP", "OSBPL3", "OSBPL6", "OSBPL8", "OSBPL9", "OSGEP", "P4HB", "PAFAH1B1", "PAICS", "PAK1IP1", "PBRM1", "PCK2", "PCNA", "PDIA3", "PDIA4", "PDIA5", "PDIA6", "PEBP1", "PEPD", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGK1", "PGM1", "PGM2", "PGM3", "PHGDH", "PHIP", "PI4KB", "PLEC", "PLOD1", "PLOD2", "PLRG1", "PLS3", "PNP", "PNPLA6", "POLA1", "POLD1", "POLR1B", "POLR1C", "POLR2B", "POLR2C", "POLR2E", "POLR2F", "PPIB", "PPIC", "PPID", "PPIF", "PPIH", "PPIL1", "PPIL3", "PPP2R2A", "PRKAR1A", "PRKAR2A", "PRKDC", "PRPF19", "PRPF4", "PSMA4", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD4", "PUS7", "PWP1", "PWP2", "PYGB", "PYGL", "QARS", "RACK1", "RAE1", "RANBP2", "RARS", "RARS2", "RBBP7", "RCL1", "RDH13", "RDX", "RIDA", "RNF14", "RNF20", "RNF40", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL15", "RPL17", "RPL18", "RPL19", "RPL21", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL37", "RPL4", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPS11", "RPS14", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS24", "RPS28", "RPS29", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS8", "RPS9", "RPSA", "RRP8", "RRP9", "RSL24D1", "RTN4IP1", "S100A11", "SART1", "SBDS", "SCD", "SCP2", "SDHB", "SEC11A", "SEC61A1", "SERPINB6", "SERPINH1", "SLC1A5", "SLC25A42", "SLC27A4", "SLIT2", "SMARCA4", "SMS", "SMU1", "SNRNP40", "SORD", "SPATA5", "SPATA5L1", "SPTBN1", "SPTBN2", "SRCAP", "SRM", "STAM", "STMN1", "STOM", "STRN", "STX10", "STX12", "STX18", "STX3", "STX4", "STX5", "STX7", "SUCLA2", "SUCLG1", "SUCLG2", "SV2A", "SYNE2", "TAP1", "TBL3", "TCP1", "TFB1M", "THOC6", "TK1", "TLN1", "TMX1", "TMX3", "TMX4", "TOP2A", "TOP2B", "TPT1", "TRAF2", "TRIM21", "TRIM25", "TRIM28", "TRIM33", "TRIP13", "TRMT11", "TSFM", "TSPAN10", "TSPAN3", "TSPAN6", "TST", "TUBB", "TUBB2A", "TUBB2B", "TUBB3", "TUBB4B", "TUBB6", "TUFM", "TXNDC12", "TXNDC5", "TXNL1", "UBA1", "UBA2", "UHRF1", "USP10", "USP11", "USP14", "USP28", "USP36", "USP47", "USP48", "USP5", "USP7", "USP9X", "UTP15", "UTP18", "UTRN", "VARS1", "VAT1", "VCL", "VCP", "VIM", "VPS4A", "VPS4B", "WARS", "WDHD1", "WDR1", "WDR11", "WDR12", "WDR18", "WDR3", "WDR36", "WDR41", "WDR48", "WDR5", "WDR61", "WDR77", "XPNPEP1", "YARS2", "YME1L1", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2"], "leading_proteins": ["ALDH2", "ALDH5A1", "ANXA1", "APP", "BAZ1A", "BRD2", "CALR", "CANX", "CBX1", "CBX3", "CD320", "CDH2", "CHD1", "DHCR7", "DIMT1", "DNM1L", "DSC3", "EEF1B2", "EPB41L3", "FCGRT", "FUCA1", "GLA", "HGS", "HLA-A", "HMOX2", "HSPA13", "IMPAD1", "IQGAP1", "LAMP2", "LMNA", "LRP1", "ME1", "MPP1", "MPP6", "MRC2", "MRPS11", "MSN", "OSBPL3", "PBRM1", "PDIA5", "POLR1B", "PRKAR1A", "PSMB1", "PSMB4", "SMS", "SRCAP", "STX10", "STX12", "STX3", "STX4", "TSPAN3", "TSPAN6", "TUBB3", "VAT1", "VCL", "VIM", "ZADH2"]}

interpro_domain/advanced/idx2term.json

@@ -0,0 +1 @@
+{"0": "Immunoglobulin-like domain [IPR007110]"}

interpro_domain/basic/idx2term.json

@@ -0,0 +1 @@
+{"0": "Immunoglobulin-like domain [IPR007110]", "1": "EF-hand domain [IPR002048]", "2": "SAP domain [IPR003034]", "3": "Target SNARE coiled-coil homology domain [IPR000727]", "4": "Myb domain [IPR017930]", "5": "Peptidase M16, C-terminal [IPR007863]", "6": "Peptidase M16, N-terminal [IPR011765]", "7": "SH3 domain [IPR001452]"}

interpro_domain/consensus.joblib

@@ -0,0 +1,3 @@
+version https://git-lfs.github.com/spec/v1
+oid sha256:40582a17a63cf398519c13f7d9433e9d5ff06355768f6c53d833cc7d1eaaa922
+size 321414

interpro_domain/df_merge.tsv

@@ -0,0 +1,2 @@
+term	overlap	setsize	score	pval	overlap_mean	setsize_mean	score_mean	pval_mean	overlap_std	setsize_std	score_std	pval_std	pval_hit	pval_50	pval_100	pval_250	pval_500
+Immunoglobulin-like domain [IPR007110]	7	10	2.536168531363124	0.0112072784304377	4.480582524271845	12.427184466019416	0.4075261998509777	0.4433674298264088	2.6479725987944898	3.173316973839475	1.1756568118942026	0.3233613924696422	1.0	0.2764907289557429	0.5530182232363337	0.0091645721783967	0.0674903225185729

interpro_domain/metrics.json

@@ -0,0 +1,7 @@
+{
+    "type_of_task": "ranksum",
+    "signature_size": 2973,
+    "annotations_size": 2448,
+    "title": "Average number of proteins per term",
+    "value": 2.110294117647059
+}

interpro_domain/paths.json

@@ -0,0 +1 @@
+{"results_path": "results/proteins/hek293t_core/interpro_domain/fragment/C221/C221_val_log2fc"}

interpro_domain/result.tsv

@@ -0,0 +1,207 @@
+Term	es	nes	pval	sidak	fdr	geneset_size	leading_edge	leading_edge_size
+Immunoglobulin-like domain [IPR007110]	0.876097204350956	2.536168531363124	0.0112072784304377	0.9999999999989584	0.1182050367201632	10	P35613,P10321,P04439,P55899,Q08722,P01889,Q9Y624	7
+Amyloidogenic glycoprotein, heparin-binding [IPR015849]	0.994614607876136	1.9102773641565869	0.0560975106647161	1.0	0.2083865039563355	2	P05067	1
+Amyloidogenic glycoprotein, extracellular [IPR008154]	0.994614607876136	1.9102773641565869	0.0560975106647161	1.0	0.2083865039563355	2	P05067	1
+Amyloidogenic glycoprotein, copper-binding [IPR011178]	0.994614607876136	1.9102773641565869	0.0560975106647161	1.0	0.2083865039563355	2	P05067	1
+Amyloidogenic glycoprotein, E2 domain [IPR024329]	0.994614607876136	1.9102773641565869	0.0560975106647161	1.0	0.2083865039563355	2	P05067	1
+Pancreatic trypsin inhibitor Kunitz domain [IPR002223]	0.994614607876136	1.9102773641565869	0.0560975106647161	1.0	0.2083865039563355	2	P05067	1
+Beta-amyloid precursor protein C-terminal [IPR019543]	0.994614607876136	1.9102773641565869	0.0560975106647161	1.0	0.2083865039563355	2	P05067	1
+Immunoglobulin C1-set [IPR003597]	0.9693499494779386	1.900940181510628	0.0573098482338556	1.0	0.2106524151298478	4	P10321,P04439,P55899	3
+MHC class I-like antigen recognition-like [IPR011161]	0.9693499494779386	1.900940181510628	0.0573098482338556	1.0	0.2106524151298478	4	P10321,P04439,P55899	3
+Peptidase C1A, papain C-terminal [IPR000668]	0.9909121507909786	1.8951553564546888	0.0580718226707648	1.0	0.2115460638482035	2	P07858	1
+Alpha-L-fucosidase, C-terminal [IPR031919]	0.9882194547290472	1.884150862671104	0.0595445719275788	1.0	0.2137318358925412	2	P04066	1
+MD-2-related lipid-recognition domain [IPR003172]	0.9851901716593736	1.8717642645484311	0.061239224226272	1.0	0.2169516945092821	2	P61916	1
+Glycoside hydrolase family 20, catalytic domain [IPR015883]	0.9784584315045428	1.844214577962371	0.0651518746580483	1.0	0.2242156019098278	2	P06865	1
+Beta-hexosaminidase, eukaryotic type, N-terminal [IPR029019]	0.9784584315045428	1.844214577962371	0.0651518746580483	1.0	0.2242156019098278	2	P06865	1
+EGF-like calcium-binding domain [IPR001881]	0.96667788623359	1.795928644106247	0.0725058662009288	1.0	0.2361778014510961	2	Q07954	1
+EGF-like domain [IPR000742]	0.96667788623359	1.795928644106247	0.0725058662009288	1.0	0.2361778014510961	2	Q07954	1
+Ricin B, lectin domain [IPR000772]	0.8370166433850649	1.7943812984930587	0.0727523298262238	1.0	0.2361778014510961	5	Q9UBG0,Q10472	2
+C-type lectin-like [IPR001304]	0.965331538202624	1.7904046789499086	0.0733888786798666	1.0	0.2363894408004125	2	Q9UBG0	1
+CD209-like, C-type lectin-like domain [IPR033989]	0.965331538202624	1.7904046789499086	0.0733888786798666	1.0	0.2363894408004125	2	Q9UBG0	1
+Cadherin prodomain [IPR014868]	0.9579266240323112	1.7600041367177306	0.0784071051857646	1.0	0.2450987857669633	2	Q14574	1
+Cadherin, cytoplasmic domain [IPR000233]	0.9579266240323112	1.7600041367177306	0.0784071051857646	1.0	0.2450987857669633	2	Q14574	1
+EF-hand domain [IPR002048]	0.508749098821014	1.7557832351334608	0.0791254280382358	1.0	0.2460259319992157	42	Q02818,Q9H4M9,Q96AY3,P0DP25,Q9UBC2,Q14257,P80303,Q9Y680,Q9H223,Q9NWM8,Q15293,Q9BRK5,O75071,O43852,P31949	15
+Alpha galactosidase A, C-terminal beta-sandwich domain [IPR035373]	0.9461460787613556	1.7115806496017754	0.0869739768473354	1.0	0.2654766774591984	2	P06280	1
+Immunoglobulin subtype 2 [IPR003598]	0.815700808625328	1.7098566634598624	0.0872923818411359	1.0	0.26567714117943	5	Q8WX93,P35613,P10586,Q9Y624	4
+Immunoglobulin subtype [IPR003599]	0.815700808625328	1.7098566634598624	0.0872923818411359	1.0	0.26567714117943	5	Q8WX93,P35613,P10586,Q9Y624	4
+Phospholipase D/Transphosphatidylase [IPR001736]	0.9387411645910436	1.6811114373634213	0.0927412712375748	1.0	0.2745231342074765	2	Q8IV08	1
+Peptidase M1, membrane alanine aminopeptidase [IPR014782]	0.8081644206792924	1.6798452000261377	0.0929874382295381	1.0	0.274587754868407	5	Q9UIQ6	1
+Aminopeptidase N-like , N-terminal domain [IPR045357]	0.8081644206792924	1.6798452000261377	0.0929874382295381	1.0	0.274587754868407	5	Q9UIQ6	1
+CBS domain [IPR000644]	0.7176084552619922	1.6354585467136442	0.1019529577962408	1.0	0.2911169663343764	7	P51790,P51798	2
+Glycosyl hydrolase, family 13, catalytic domain [IPR006047]	0.9262874453046088	1.6298251021147907	0.1031384668583625	1.0	0.2926247627847179	2	P08195	1
+Band 7 domain [IPR001107]	0.7015773242252963	1.629724240379574	0.1031597917823576	1.0	0.2926247627847179	8	O75955,P27105	2
+Chromo domain [IPR023780]	0.7433491664637353	1.625993135506782	0.1039511156555565	1.0	0.2935090324392186	6	P83916,Q13185,O14646	3
+S100/CaBP-9k-type, calcium binding, subdomain [IPR013787]	0.920228879165264	1.6048606008720807	0.108524485846269	1.0	0.2985033048895131	2	P31949	1
+Lipocalin/cytosolic fatty-acid binding domain [IPR000566]	0.9171995960955888	1.5923758900934353	0.1113002702090351	1.0	0.303061065420405	2	Q01469	1
+Cytosolic fatty-acid binding [IPR000463]	0.9171995960955888	1.5923758900934353	0.1113002702090351	1.0	0.303061065420405	2	Q01469	1
+MHC class I alpha chain, alpha1 alpha2 domains [IPR001039]	0.9690235690235696	1.5895157820724708	0.1119439938565336	1.0	0.3031383587725731	3	P10321,P04439	2
+MHC class I, alpha chain, C-terminal [IPR010579]	0.9690235690235696	1.5895157820724708	0.1119439938565336	1.0	0.3031383587725731	3	P10321,P04439	2
+Chromo/chromo shadow domain [IPR000953]	0.69147703903338	1.5847789646240082	0.1130165633451294	1.0	0.3050325767021795	8	P83916,P45973,Q13185,O14646	4
+Fibronectin type II domain [IPR000562]	0.963510695075477	1.5691825035345248	0.1166054198682375	1.0	0.3126506767113314	3	P11717	1
+MENTAL domain [IPR019498]	0.9101312689330135	1.5632407302680813	0.1179959832683597	1.0	0.3150710817820327	2	O95772	1
+FKBP-type peptidyl-prolyl cis-trans isomerase domain [IPR001179]	0.6416818890675499	1.5573868715131742	0.1193786612388723	1.0	0.3162759336718175	11	Q96AY3,P26885,P62942,Q9Y680	4
+Cadherin-like [IPR002126]	0.9572390572390564	1.546040740978816	0.122094728826009	1.0	0.3184412479972855	3	Q14574,P19022	2
+VHS domain [IPR002014]	0.9037361157859268	1.5368781685342956	0.1243231465870375	1.0	0.3213759903327011	2	O14964	1
+Vacuolar protein sorting-associated protein 13, SHR-binding domain [IPR009543]	0.8855604173678862	1.461972099866372	0.1437488555350548	1.0	0.3487583729928782	2	Q96RL7	1
+VPS13, repeated coiled region [IPR031642]	0.8855604173678862	1.461972099866372	0.1437488555350548	1.0	0.3487583729928782	2	Q96RL7	1
+Vacuolar protein sorting-associated protein 13-like, N-terminal domain [IPR026854]	0.8855604173678862	1.461972099866372	0.1437488555350548	1.0	0.3487583729928782	2	Q96RL7	1
+Vacuolar protein sorting-associated protein 13, second N-terminal domain [IPR031646]	0.8855604173678862	1.461972099866372	0.1437488555350548	1.0	0.3487583729928782	2	Q96RL7	1
+Vacuolar protein sorting-associated protein 13, C-terminal [IPR031645]	0.8855604173678862	1.461972099866372	0.1437488555350548	1.0	0.3487583729928782	2	Q96RL7	1
+Prolyl 4-hydroxylase alpha subunit, Fe(2+) 2OG dioxygenase domain [IPR044862]	0.8835408953214385	1.453653443667262	0.1460424118300645	1.0	0.3495108274372467	2	P13674	1
+High mobility group box domain [IPR009071]	0.6196476746424447	1.4506569717048332	0.1468754025917042	1.0	0.3497333075067725	11	P26583,P17480,O96028	3
+Matrin/U1-C, C2H2-type zinc finger [IPR000690]	0.7341392917150048	1.3822558533952	0.1668931558904445	1.0	0.3789929922261671	5	P09234	1
+Syntaxin, N-terminal domain [IPR006011]	0.8255304816436506	1.3596314548185533	0.1739465790922838	1.0	0.3892332958116186	4	Q13277,Q86Y82,Q12846	3
+PWWP domain [IPR000313]	0.6785741213831015	1.353017318706687	0.1760500976586558	1.0	0.3910802730017556	6	O96028,Q7Z4V5,O75475,P52701	4
+GMP phosphodiesterase, delta subunit [IPR008015]	0.8976430976431036	1.3260384104941432	0.1848269748327231	1.0	0.4025413117353258	3	O43924,Q13432	2
+Zinc finger, FYVE-related [IPR017455]	0.8110787685631609	1.304827235438106	0.1919516828886518	1.0	0.4100329142333505	4	Q96T51,O14964	2
+FYVE zinc finger [IPR000306]	0.8110787685631609	1.304827235438106	0.1919516828886518	1.0	0.4100329142333505	4	Q96T51,O14964	2
+MRH domain [IPR044865]	0.8906473140083699	1.3002613872671476	0.1935113972556248	1.0	0.4112117191682027	3	P11717	1
+Domain of unknown function DUF5600 [IPR040990]	0.8428138673847168	1.2863538673501258	0.1983195908132571	1.0	0.4180266243213814	2	Q9H4M9	1
+EH domain-containing protein, N-terminal [IPR031692]	0.8428138673847168	1.2863538673501258	0.1983195908132571	1.0	0.4180266243213814	2	Q9H4M9	1
+Pleckstrin homology domain 8 [IPR041680]	0.823291820935701	1.2066963793833	0.2275490939524407	1.0	0.4503154260271422	2	Q9H4L5	1
+ERAP1-like C-terminal domain [IPR024571]	0.8589225589225725	1.1837530246790904	0.2365108423498028	1.0	0.4604602591306058	3	P55786,Q9UIQ6	2
+Spt5 C-terminal domain [IPR024945]	0.8081454055873424	1.14527277311689	0.2520961808170305	1.0	0.4780259106429828	2	Q9UQ35	1
+EH domain [IPR000261]	0.8430976430976431	1.1259802344699976	0.2601738857044395	1.0	0.4899274401572831	3	Q9H4M9,Q9UBC2	2
+Chromo domain subgroup [IPR017984]	0.8356902356902369	1.099043729105799	0.2717489924357195	1.0	0.5066576797278304	3	P83916,Q13185	2
+Chromo shadow domain [IPR008251]	0.8356902356902369	1.099043729105799	0.2717489924357195	1.0	0.5066576797278304	3	P83916,Q13185	2
+Dynamin-type guanine nucleotide-binding (G) domain [IPR030381]	0.5931509153936961	1.0875167183464156	0.2768085141076555	1.0	0.511416786819276	7	Q9H4M9,Q9H223	2
+Dynamin, N-terminal [IPR045063]	0.5931509153936961	1.0875167183464156	0.2768085141076555	1.0	0.511416786819276	7	Q9H4M9,Q9H223	2
+Oxoglutarate/iron-dependent dioxygenase [IPR005123]	0.7458840678143008	1.0589485634311635	0.289623205678684	1.0	0.5265377409803689	4	P13674	1
+Prolyl 4-hydroxylase, alpha subunit [IPR006620]	0.7458840678143008	1.0589485634311635	0.289623205678684	1.0	0.5265377409803689	4	P13674	1
+Pleckstrin homology domain 9 [IPR041681]	0.7855940760686617	1.054639847765421	0.2915900720691147	1.0	0.5265377409803689	2	O15020	1
+Pleckstrin homology domain, spectrin-type [IPR001605]	0.7855940760686617	1.054639847765421	0.2915900720691147	1.0	0.5265377409803689	2	O15020	1
+SWIRM domain [IPR007526]	0.7397603905134991	1.0360794629841834	0.300165072413757	1.0	0.5352748669935046	4	Q8NB78	1
+Marvel domain [IPR008253]	0.7781891618983402	1.0251409374065883	0.3052966918001485	1.0	0.5407089485064015	2	Q16625	1
+Immunoglobulin I-set [IPR013098]	0.8151515151515182	1.0247925255991788	0.3054610939208289	1.0	0.5407089485064015	3	Q8WX93,P10586	2
+Band 4.1, C-terminal [IPR008379]	0.8132038805145897	1.017789400046105	0.3087780505246045	1.0	0.5430234681639596	3	Q9Y2J2	1
+SAB domain [IPR007477]	0.8132038805145897	1.017789400046105	0.3087780505246045	1.0	0.5430234681639596	3	Q9Y2J2	1
+Tudor domain [IPR002999]	0.6425837982136444	1.0122143593781068	0.3114355719425095	1.0	0.5461277078189565	5	Q9Y2W6	1
+WSTF/Acf1/Cbp146 [IPR013136]	0.7637159205654627	0.9679299913367836	0.3330793347690259	1.0	0.5678121250101501	2	Q9NRL2	1
+DDT domain [IPR018501]	0.7637159205654627	0.9679299913367836	0.3330793347690259	1.0	0.5678121250101501	2	Q9NRL2	1
+WHIM1 domain [IPR028942]	0.7637159205654627	0.9679299913367836	0.3330793347690259	1.0	0.5678121250101501	2	Q9NRL2	1
+WHIM2 domain [IPR028941]	0.7637159205654627	0.9679299913367836	0.3330793347690259	1.0	0.5678121250101501	2	Q9NRL2	1
+Tubulin/FtsZ, GTPase domain [IPR003008]	0.5838395325113144	0.9508077790205736	0.3417019629562268	1.0	0.574904745922229	6	Q13509	1
+Tubulin/FtsZ, 2-layer sandwich domain [IPR018316]	0.5838395325113144	0.9508077790205736	0.3417019629562268	1.0	0.574904745922229	6	Q13509	1
+SUN domain [IPR012919]	0.7858260101101352	0.9201967988561358	0.357469926848424	1.0	0.5892837581986142	3	O94901	1
+SAP domain [IPR003034]	0.4974730370508385	0.9029595212384576	0.3665473787509576	1.0	0.5928753872682588	12	Q9UKV3,Q13435,Q9NWH9,Q9BUJ2,P35659,Q14151,P82979	7
+Peptidase M3A/M3B catalytic domain [IPR001567]	0.7772592602098207	0.8900347029695446	0.3734472524359105	1.0	0.5971085302199787	3	Q99797	1
+FF domain [IPR002713]	0.7425109390777503	0.88536308537189	0.3759608353310928	1.0	0.5971085302199787	2	O75400	1
+CNNM, transmembrane domain [IPR002550]	0.7421743520699962	0.8840661238650234	0.3766605188882286	1.0	0.5971085302199787	2	Q8NE01	1
+Ion transporter-like, CBS domain [IPR044751]	0.7421743520699962	0.8840661238650234	0.3766605188882286	1.0	0.5971085302199787	2	Q8NE01	1
+Major facilitator superfamily domain [IPR020846]	0.7708706893492996	0.8676763069926814	0.3855715598700664	1.0	0.6063955960166945	3	Q7L0J3	1
+N-acetylgalactosaminyltransferase [IPR045885]	0.7700092178403144	0.8646706502924004	0.3872195828668929	1.0	0.6075993869439099	3	Q10472	1
+Zinc finger, LIM-type [IPR001781]	0.5104836545338101	0.859490116762089	0.3900701703727309	1.0	0.6096555823330833	10	Q14847,Q9UGI8,Q15942,Q9NR12	4
+Lens epithelium-derived growth factor, integrase-binding domain [IPR021567]	0.7293840457758188	0.8351351295188787	0.403641629293139	1.0	0.6226305661686228	2	Q7Z4V5	1
+Polyamine biosynthesis  domain [IPR030374]	0.729047458768082	0.8338571870400153	0.4043614652388108	1.0	0.6226595138527087	2	P52788	1
+Spermidine synthase, tetramerisation domain [IPR035246]	0.729047458768082	0.8338571870400153	0.4043614652388108	1.0	0.6226595138527087	2	P52788	1
+U-box domain [IPR003613]	0.5949653987937821	0.8234295966082953	0.4102637381254614	1.0	0.6285479495451523	5	P19474	1
+Zinc finger, CCHC-type [IPR001878]	0.5509459377867172	0.8133104259528278	0.4160401009182766	1.0	0.6339480729017335	6	Q8TBF4,Q9NUD5,Q16629	3
+Heterogeneous nuclear ribonucleoprotein Q acidic domain [IPR041337]	0.7202961965668052	0.800817943785192	0.423237049425732	1.0	0.6387696035722515	2	O60506	1
+mRNA splicing factor Cwf21 domain [IPR013170]	0.7199596095590618	0.7995546169827624	0.4239688905313656	1.0	0.6394798792487881	2	Q9UQ35	1
+Histone-binding protein RBBP4, N-terminal [IPR022052]	0.7162571524739116	0.7856956870920517	0.4320457905575816	1.0	0.6472754561107465	2	Q16576	1
+Aldehyde dehydrogenase domain [IPR015590]	0.4997011568967058	0.7598925117974178	0.4473188380148887	1.0	0.6605783672144218	9	P51649,P05091	2
+Target SNARE coiled-coil homology domain [IPR000727]	0.4994320708287318	0.7586536226576267	0.4480597865925628	1.0	0.6605783672144218	9	Q86Y82,O00161,Q12846,O60499,Q13277,Q9UNK0	6
+Fibronectin type III [IPR003961]	0.7387735438647878	0.757375708902995	0.448824804811893	1.0	0.6605783672144218	3	P10586	1
+Butyrophylin-like, SPRY domain [IPR003879]	0.7024570851565003	0.734681051479385	0.4625337629779764	1.0	0.6681289012251893	2	P19474	1
+SPRY-associated [IPR006574]	0.7024570851565003	0.734681051479385	0.4625337629779764	1.0	0.6681289012251893	2	P19474	1
+Gamma-glutamyl cyclotransferase-like [IPR013024]	0.701110737125539	0.7297611727196078	0.4655361816531875	1.0	0.6707666702101255	2	Q8WUX2	1
+TRAM/LAG1/CLN8 homology domain [IPR006634]	0.6550241216700694	0.7285155761982567	0.4662980372713754	1.0	0.6709790566360999	4	Q96CP7	1
+L27 domain, C-terminal [IPR014775]	0.6974082800403791	0.7162867253928206	0.4738143217968307	1.0	0.6764952847989825	2	Q9NZW5	1
+L27 domain [IPR004172]	0.6974082800403791	0.7162867253928206	0.4738143217968307	1.0	0.6764952847989825	2	Q9NZW5	1
+RII binding domain [IPR018459]	0.6913497139010392	0.6944177166833913	0.4874202863085175	1.0	0.686105598725951	2	Q02952	1
+Glycosyltransferase 2-like [IPR001173]	0.6426043085927196	0.6854933671257668	0.4930326447458253	1.0	0.686105598725951	4	Q10472	1
+Sterile alpha motif domain [IPR001660]	0.4831087695861155	0.6452271816759149	0.5187799738301764	1.0	0.7075354199681193	8	Q6SZW1,Q8IXK0,Q15375,Q9Y6Y8	4
+Tyrosine-specific protein phosphatase, PTPase domain [IPR000242]	0.7043104557938279	0.6436402292402854	0.5198087569384278	1.0	0.7081201096189601	3	P10586	1
+cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain [IPR003117]	0.6718276674520255	0.6255949421530178	0.5315806571217248	1.0	0.7165800928601224	2	P10644	1
+Myosin tail [IPR002928]	0.6704813194210621	0.6209475710286584	0.5346341198809368	1.0	0.7195076005874289	2	P35579	1
+HDGF-related, PWWP domain [IPR035496]	0.6851851851852016	0.5831555455929514	0.559788594090759	1.0	0.7376190820648368	3	Q7Z4V5,O75475	2
+Man1/Src1, C-terminal [IPR018996]	0.6543251430494703	0.5662686565035184	0.5712111640340454	1.0	0.7435136212831212	2	Q9Y2U8	1
+Uncharacterised domain CHP00451 [IPR004521]	0.6270615954224066	0.4790408083896767	0.6319095976004514	1.0	0.7843421300449934	2	Q9ULC4	1
+Intermediate filament head, DNA-binding domain [IPR006821]	0.5634893903671259	0.4324377022502794	0.6654233210683618	1.0	0.799840430742773	4	Q16352,P08670,P07196	3
+Histone deacetylase domain [IPR023801]	0.6075395489733978	0.4209951179236451	0.6737586468466064	1.0	0.8057455630095224	2	Q13547	1
+Domain of unknown function DUF4749 [IPR031847]	0.605183439919208	0.4142612336314019	0.6786828013176414	1.0	0.8080814677167247	2	O00151	1
+RNA recognition motif domain, eukaryote [IPR003954]	0.3885940245163854	0.4061061027219901	0.6846646418999329	1.0	0.8131025694086311	13	Q9UHX1,Q14011,Q01081,Q8TBF4	4
+Core histone macro-H2A, macro domain [IPR035796]	0.598451699764377	0.3953588084250526	0.6925781041118866	1.0	0.8170752765618787	2	Q9P0M6	1
+Domain of unknown function DUF1747 [IPR013719]	0.5944126556714783	0.3842618203851855	0.7007844026940044	1.0	0.824713026427038	2	Q9Y5B9	1
+Clathrin/coatomer adaptor, adaptin-like, N-terminal [IPR002553]	0.4047467701490777	0.3761217750587222	0.7068263667408727	1.0	0.8290900554775547	10	P53618	1
+Myb domain [IPR017930]	0.4347826086956554	0.3671672688250799	0.7134942525389019	1.0	0.8326424762812312	6	Q96KC8,Q13330,Q8TAQ2,Q99459,Q92922	5
+Guanylate kinase/L-type calcium channel beta subunit [IPR008145]	0.4607960158904113	0.3475400648770161	0.7281856245713136	1.0	0.8436338897068508	5	Q00013,Q07157,Q9NZW5	3
+Guanylate kinase-like domain [IPR008144]	0.4607960158904113	0.3475400648770161	0.7281856245713136	1.0	0.8436338897068508	5	Q00013,Q07157,Q9NZW5	3
+Dynamin GTPase effector [IPR003130]	0.5799394143385965	0.3460556818215944	0.7293008687989277	1.0	0.8437280372494211	2	O00429	1
+Dynamin stalk domain [IPR000375]	0.5799394143385965	0.3460556818215944	0.7293008687989277	1.0	0.8437280372494211	2	O00429	1
+GTPase effector domain [IPR020850]	0.5799394143385965	0.3460556818215944	0.7293008687989277	1.0	0.8437280372494211	2	O00429	1
+Dynamin, GTPase domain [IPR001401]	0.5801346801346738	0.2985821112995545	0.7652589162638457	1.0	0.8716188428198599	3	O60313,O00429	2
+EF-hand, Ca insensitive [IPR014837]	0.5797979797979891	0.2978296054634641	0.7658332174717131	1.0	0.8716188428198599	3	O43707,P12814	2
+Peptidase C19, ubiquitin-specific peptidase, DUSP domain [IPR006615]	0.5600807808818449	0.2977801462613975	0.7658709685071563	1.0	0.8716188428198599	2	Q86UV5	1
+JmjC domain [IPR003347]	0.5567149108044298	0.290091250847534	0.7717464289684761	1.0	0.8771029703577135	2	Q9Y2K7	1
+Phospholipid/glycerol acyltransferase [IPR002123]	0.3977382057630626	0.2856823936606471	0.7751213907758592	1.0	0.8780643982504874	7	Q9NUQ2	1
+DZF domain [IPR006561]	0.5052206130010091	0.2789510986654935	0.780282353227489	1.0	0.8822776908549159	4	Q96SI9,Q12905,Q96KR1	3
+RWD domain [IPR006575]	0.550992931672821	0.2773559145527369	0.7815068292596958	1.0	0.8832542557838114	2	Q6P158	1
+Methyltransferase type 11 [IPR013216]	0.4361253040213683	0.2767738179611727	0.7819537863356756	1.0	0.8833515777340719	5	O43709	1
+Zinc finger, CCCH-type [IPR000571]	0.3600596776838812	0.2747625108684445	0.7834987018985196	1.0	0.8840712871298951	13	Q01081,Q86VM9	2
+Elongation factor 1 beta central acidic region, eukaryote [IPR018940]	0.5456075395489566	0.2657595064568568	0.7904244311632913	1.0	0.8896363252817182	2	P24534	1
+Translation elongation factor EF1B, beta/delta subunit, guanine nucleotide exchange domain [IPR014038]	0.5456075395489566	0.2657595064568568	0.7904244311632913	1.0	0.8896363252817182	2	P24534	1
+Far upstream element-binding protein, C-terminal [IPR015096]	0.5398855604173506	0.2538561766822119	0.7996066718544399	1.0	0.8973080299060372	2	Q96AE4	1
+Zinc finger, CHHC-type [IPR012996]	0.5585858585858487	0.2528143721962749	0.8004116610016869	1.0	0.8975756968081217	3	P52597,P55795	2
+CTP synthase, N-terminal [IPR017456]	0.5351733423089715	0.2443788510168268	0.8069374197507861	1.0	0.8996513824241354	2	P17812	1
+CTP synthase GATase domain [IPR033828]	0.5351733423089715	0.2443788510168268	0.8069374197507861	1.0	0.8996513824241354	2	P17812	1
+Intermediate filament, rod domain [IPR039008]	0.3775510268820693	0.2292533990301012	0.8186719711134998	1.0	0.907139661208598	8	P02545,P08670	2
+Ribosomal RNA adenine methylase transferase, N-terminal [IPR020598]	0.5223830360147944	0.220145697022621	0.8257576865859793	1.0	0.9109755821372136	2	Q9UNQ2	1
+UBX domain [IPR001012]	0.4080188679245172	0.2054566402465061	0.8372153714843067	1.0	0.9219537694078196	5	Q96CS3,Q92575,Q04323,O94888	4
+Ubiquitin conjugation factor E4, core [IPR019474]	0.5126220127902892	0.2031218988259117	0.8390397557131175	1.0	0.92313227954414	2	Q14139	1
+Serine-threonine/tyrosine-protein kinase, catalytic domain [IPR001245]	0.406744634114505	0.2024767100976145	0.8395440639830516	1.0	0.9232721781808224	5	Q15375	1
+Hyaluronan-mediated motility receptor, C-terminal [IPR031794]	0.5106024907438513	0.1997583434385895	0.8416695817528235	1.0	0.9247787864142334	2	Q9NS87	1
+Cation-transporting P-type ATPase, C-terminal [IPR006068]	0.5272727272727173	0.1952809280211983	0.8451730268770574	1.0	0.9268878982924116	3	P20020,P05023	2
+Cation-transporting P-type ATPase, N-terminal [IPR004014]	0.5272727272727173	0.1952809280211983	0.8451730268770574	1.0	0.9268878982924116	3	P20020,P05023	2
+Alcohol dehydrogenase, N-terminal [IPR013154]	0.4033438213842373	0.1946351161132839	0.8456786100761413	1.0	0.9268878982924116	5	Q8N4Q0,Q00796,Q99536	3
+Peptidase M16, C-terminal [IPR007863]	0.3664868509777483	0.1876670246641905	0.8511376814428997	1.0	0.9305873354945148	7	P22695,P31930,P14735,Q10713,O43847,O75439	6
+Peptidase M16, N-terminal [IPR011765]	0.3664868509777483	0.1876670246641905	0.8511376814428997	1.0	0.9305873354945148	7	P22695,P31930,P14735,Q10713,O43847,O75439	6
+CARG-binding factor, N-terminal [IPR012956]	0.5008414675193456	0.1842634440755005	0.8538067902563873	1.0	0.932655872093621	2	Q14103	1
+Heterogeneous nuclear ribonucleoprotein U, SPRY domain [IPR035778]	0.5202020202020186	0.1837971708461918	0.8541725756674421	1.0	0.932655872093621	3	Q9BUJ2,Q00839	2
+RNA polymerase Rpb2, domain 2 [IPR007642]	0.4897340962638812	0.1681519491234903	0.8664637416384717	1.0	0.9389567240066308	2	Q9H9Y6	1
+RNA polymerase, beta subunit, protrusion [IPR007644]	0.4897340962638812	0.1681519491234903	0.8664637416384717	1.0	0.9389567240066308	2	Q9H9Y6	1
+DNA-directed RNA polymerase, subunit 2, hybrid-binding domain [IPR007120]	0.4897340962638812	0.1681519491234903	0.8664637416384717	1.0	0.9389567240066308	2	Q9H9Y6	1
+RNA polymerase Rpb2, domain 7 [IPR007641]	0.4897340962638812	0.1681519491234903	0.8664637416384717	1.0	0.9389567240066308	2	Q9H9Y6	1
+RNA polymerase Rpb2, domain 3 [IPR007645]	0.4897340962638812	0.1681519491234903	0.8664637416384717	1.0	0.9389567240066308	2	Q9H9Y6	1
+Bromo adjacent homology (BAH) domain [IPR001025]	0.4462281138292979	0.1619702834971629	0.8713292551702669	1.0	0.9414120642609342	4	Q86U86	1
+OCRE domain [IPR041591]	0.5043771043770972	0.1601155323769384	0.8727900659624657	1.0	0.9420591188166296	3	P52756,P78332	2
+Peptidase M16, middle/third domain [IPR032632]	0.4776169639851734	0.1523815169462672	0.8788860341728517	1.0	0.9465521388715974	2	P14735	1
+Fumarylacetoacetase-like, C-terminal [IPR011234]	0.4749242679232551	0.1491269668098091	0.8814534473714812	1.0	0.9488647272498344	2	Q6P587	1
+Nuclear transport factor 2 domain [IPR002075]	0.4313701606799081	0.1392006353119044	0.8892916064858645	1.0	0.9523122715124218	4	Q9UN86	1
+Nuclear transport factor 2, eukaryote [IPR018222]	0.4313701606799081	0.1392006353119044	0.8892916064858645	1.0	0.9523122715124218	4	Q9UN86	1
+ATPase family AAA domain-containing protein 3, N-terminal [IPR021911]	0.4654998317064926	0.1384325697790543	0.8898985578466923	1.0	0.9525455485827296	2	Q5T9A4	1
+EB1, C-terminal [IPR004953]	0.4607876135981088	0.1334827170449416	0.8938116317529008	1.0	0.9557840260318042	2	Q15691	1
+Ancestral coatomer element 1, Sec16/Sec31 [IPR024298]	0.4597778525748837	0.1324557470796024	0.8946238232614383	1.0	0.9559315230659104	2	O15027	1
+PWI domain [IPR002483]	0.4257325698888499	0.1312687891658565	0.8955626807504429	1.0	0.9565172087596352	4	Q9P2N5,P49756,Q8IYB3	3
+Reticulon [IPR003388]	0.4714782939071954	0.119642103960208	0.9047666651193982	1.0	0.9634053050075192	3	O75298	1
+NIPSNAP [IPR012577]	0.442275328172327	0.1164734767259135	0.9072773055165072	1.0	0.9655625822878184	2	Q9BPW8	1
+RasGAP protein, C-terminal [IPR000593]	0.4375631100639504	0.1127329678394294	0.9102422632904152	1.0	0.9659729314689972	2	P46940	1
+Metastasis-associated protein MTA1, R1 domain [IPR035170]	0.4368899360484496	0.1122171805610534	0.910651207092966	1.0	0.9659729314689972	2	O94776	1
+ELM2 domain [IPR000949]	0.4368899360484496	0.1122171805610534	0.910651207092966	1.0	0.9659729314689972	2	O94776	1
+Potassium channel tetramerisation-type BTB domain [IPR003131]	0.4335240659710488	0.109706517603301	0.9126421313204348	1.0	0.9675824761682218	2	Q9NXV2	1
+Serine-threonine protein phosphatase, N-terminal [IPR031675]	0.4197239986536411	0.1005521538743862	0.9199059797959656	1.0	0.973176248288904	2	P62140	1
+Thioesterase domain [IPR006683]	0.4170313025917184	0.098968757424847	0.9211630762511838	1.0	0.9740851881913166	2	Q9NPJ3	1
+Putative WW-binding domain and destruction box [IPR033461]	0.4119824974755801	0.0961678480188942	0.9233872659945912	1.0	0.9755943146977814	2	Q9ULX3	1
+CAP Gly-rich domain [IPR000938]	0.4434343434343355	0.093917650137499	0.9251745730269728	1.0	0.9763243570956094	3	Q99426,Q14203	2
+UAS [IPR006577]	0.4431160421995104	0.0936685669903379	0.9253724403729302	1.0	0.9763243570956094	3	O94888	1
+Heat shock protein DnaJ, cysteine-rich domain [IPR001305]	0.4400673400673241	0.0913291134026417	0.9272310855002368	1.0	0.9767046890295094	3	Q96EY1,O60884	2
+Protein-tyrosine phosphatase, catalytic [IPR003595]	0.3897522693227676	0.0895079273117895	0.9286782537893552	1.0	0.9778083291511148	4	P10586	1
+CRAL-TRIO lipid binding domain [IPR001251]	0.3712554695388717	0.0804259915066974	0.9358984556252764	1.0	0.9797649420335058	2	Q07960	1
+Lysophosphatidylcholine acyltransferase LPCAT1-like [IPR045252]	0.3709188825311316	0.0803385785363119	0.9359679761247404	1.0	0.9797649420335058	2	Q86UL3	1
+FERM, N-terminal [IPR018979]	0.3264660980052861	0.0791153617651409	0.9369408648916636	1.0	0.9797649420335058	8	Q9Y2J2,P26038	2
+FERM, C-terminal PH-like domain [IPR018980]	0.3264660980052861	0.0791153617651409	0.9369408648916636	1.0	0.9797649420335058	8	Q9Y2J2,P26038	2
+ATP-grasp fold, succinyl-CoA synthetase-type [IPR013650]	0.3493773140356748	0.0758420563783904	0.9395447563073354	1.0	0.9809744055990977	2	Q96I99	1
+Malic enzyme, NAD-binding [IPR012302]	0.3258162234937731	0.0728834338345929	0.941898876764776	1.0	0.9809744055990977	2	P48163	1
+Malic enzyme, N-terminal domain [IPR012301]	0.3258162234937731	0.0728834338345929	0.941898876764776	1.0	0.9809744055990977	2	P48163	1
+Zinc finger, UBP-type [IPR001607]	0.4098788274084604	0.0723896278045146	0.9422918389525248	1.0	0.9809744055990977	3	Q7Z569	1
+Disulphide isomerase [IPR005788]	0.3345687331536412	0.0722402752070902	0.9424106939042228	1.0	0.9809744055990977	5	P30101,P07237,Q15084,P13667	4
+G-patch domain [IPR000467]	0.3073061726438357	0.0721420539186128	0.9424888592064568	1.0	0.9809744055990977	15	Q9UKJ3,Q5T3I0,Q96BK5,P52756	4
+HECT domain [IPR000569]	0.3219793608746137	0.0714073797221405	0.9430735364361368	1.0	0.9809744055990977	6	O95071	1
+SH3 domain [IPR001452]	0.3053526470007642	0.0707708568479941	0.943580126515162	1.0	0.9809744055990977	29	P46108,Q9UJU6,Q15149,P15924,Q9UQB8,Q9NZW5,Q9Y5K6,Q00013,Q14847,Q9UNF0,P62993,Q9Y371,Q92783	13
+SWIB/MDM2 domain [IPR003121]	0.2840794345338243	0.070611452257919	0.9437069955824652	1.0	0.9809744055990977	2	Q96GM5	1
+Domain of unknown function DUF4217 [IPR025313]	0.3249158249158246	0.0490830833953531	0.960853084652139	1.0	0.9900153159495488	3	Q8NHQ9,Q9NVP1	2
+Zinc finger C2H2 AKAP95-type [IPR034736]	0.3094276094276089	0.0476966569338296	0.9619579984527408	1.0	0.9900153159495488	3	Q5BKZ1,O43823	2
+Ras GTPase-activating domain [IPR001936]	0.3067340067340057	0.0475053424502545	0.9621104724852844	1.0	0.9900153159495488	3	Q13576,P46940	2
+Ran binding domain [IPR000156]	0.317952172448634	0.0452008166070688	0.9639472433589262	1.0	0.9910721762883878	4	P49792,Q9H6Z4,Q9UKX7	3
+Zinc finger, GATA-type [IPR000679]	0.260357022566519	0.0338763763515515	0.972975731313747	1.0	0.9949697461369148	4	O94776,Q13330,Q8WXI9	3
+FERM domain [IPR000299]	0.2967105985953001	0.0026994830024872	0.9978461268061198	1.0	1.0	9	Q9Y2J2,P26038	2

interpro_family/advanced/idx2term.json

@@ -0,0 +1 @@
+{}

interpro_family/basic/idx2term.json

@@ -0,0 +1 @@
+{"0": "Syntaxin [IPR045242]"}

interpro_family/consensus.joblib

@@ -0,0 +1,3 @@
+version https://git-lfs.github.com/spec/v1
+oid sha256:62eb87fc3e7eef28176580972a07096299dc4b3b05f5ee580491310b4f5ea344
+size 380136

interpro_family/df_merge.tsv

@@ -0,0 +1 @@
+term	overlap	setsize	score	pval	overlap_mean	setsize_mean	score_mean	pval_mean	overlap_std	setsize_std	score_std	pval_std	pval_hit	pval_50	pval_100	pval_250	pval_500

interpro_family/metrics.json

@@ -0,0 +1,7 @@
+{
+    "type_of_task": "ranksum",
+    "signature_size": 2973,
+    "annotations_size": 2322,
+    "title": "Average number of proteins per term",
+    "value": 1.2863910422049958
+}

interpro_family/paths.json

@@ -0,0 +1 @@
+{"results_path": "results/proteins/hek293t_core/interpro_family/fragment/C221/C221_val_log2fc"}

interpro_family/result.tsv

@@ -0,0 +1,99 @@
+Term	es	nes	pval	sidak	fdr	geneset_size	leading_edge	leading_edge_size
+Annexin [IPR001464]	0.7897153223101487	1.943650107687729	0.0519376589472724	1.0	0.1566223949033332	7	P04083	1
+Amyloidogenic glycoprotein [IPR008155]	0.994614607876136	1.9102773641565869	0.0560975106647161	1.0	0.1636412308586317	2	P05067	1
+Palmitoyl protein thioesterase [IPR002472]	0.989902389767754	1.8910293212016216	0.0586204302621786	1.0	0.1686699368882018	2	Q9UMR5	1
+Alpha-L-fucosidase, metazoa-type [IPR016286]	0.9882194547290472	1.884150862671104	0.0595445719275788	1.0	0.1704978935457431	2	P04066	1
+Glycoside hydrolase, family 29 [IPR000933]	0.9882194547290472	1.884150862671104	0.0595445719275788	1.0	0.1704978935457431	2	P04066	1
+Tetraspanin, animals [IPR000301]	0.9858633456748565	1.874517432021025	0.0608591416796955	1.0	0.1724156587119781	2	O60637	1
+Lysosome-associated membrane glycoprotein [IPR002000]	0.9808145405587338	1.8538606353333924	0.0637591009124098	1.0	0.1770916654528896	2	P13473	1
+Beta-hexosaminidase [IPR025705]	0.9784584315045428	1.844214577962371	0.0651518746580483	1.0	0.1781466661264175	2	P06865	1
+CD36 family [IPR002159]	0.9663412992258482	1.7945477548197215	0.0727257835321804	1.0	0.189343386751445	2	Q14108	1
+Mitochondrial inner membrane translocase complex, subunit Tim17 [IPR005678]	0.964658364187142	1.787642291316763	0.0738337377346047	1.0	0.1911281371457662	2	Q99595	1
+Desmosomal cadherin [IPR009122]	0.9569168630090868	1.7558562627725445	0.0791129546786173	1.0	0.1994574166815955	2	Q14574	1
+Chloride channel, voltage gated [IPR001807]	0.9474924267923232	1.7171180716314327	0.0859576008931219	1.0	0.210764043583769	2	P51790	1
+Glycoside hydrolase, family 27 [IPR002241]	0.9461460787613556	1.7115806496017754	0.0869739768473354	1.0	0.2119135091705276	2	P06280	1
+Transmembrane protein GPR107/GPR108-like [IPR009637]	0.941770447660719	1.6935787359500734	0.0903453615357712	1.0	0.2160473012214838	2	Q8NBN3	1
+Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase [IPR001930]	0.8081644206792924	1.6798452000261377	0.0929874382295381	1.0	0.2196508968148398	5	Q9UIQ6	1
+Peptidase S10, serine carboxypeptidase [IPR001563]	0.9858585858585855	1.6515445088216008	0.0986274402183542	1.0	0.2286753682835224	3	P10619,Q9HB40	2
+Sodium/potassium-transporting ATPase subunit beta [IPR000402]	0.9229215752271952	1.6159568415201315	0.1061036446830483	1.0	0.2396621234961461	2	P54709	1
+Syntaxin [IPR045242]	0.7100772559047933	1.6027723427177378	0.1089849250726755	1.0	0.2438997063729212	7	Q86Y82,Q12846,O60499,Q13277,Q9UNK0	5
+Intracellular lipid binding protein [IPR031259]	0.9171995960955888	1.5923758900934353	0.1113002702090351	1.0	0.2470738311906114	2	Q01469	1
+Flotillin family [IPR027705]	0.9155166610568812	1.585439392892691	0.1128665368913499	1.0	0.2493587998684249	2	O75955	1
+Tetraspanin/Peripherin [IPR018499]	0.966329966329968	1.5795820069984716	0.1142026224995644	1.0	0.251115993791656	3	O43657,O60637	2
+Ergosterol biosynthesis ERG4/ERG24 [IPR001171]	0.9094580949175308	1.5604657601197522	0.1186498552582511	1.0	0.2567613829540159	2	Q9UBM7	1
+Acidic leucine-rich nuclear phosphoprotein 32 [IPR045081]	0.905419050824636	1.5438156923841748	0.1226329886408117	1.0	0.2624458982709353	2	Q92688	1
+Sulfotransferase [IPR005331]	0.9017165937394768	1.5285532668776485	0.1263752288805459	1.0	0.2672525332064005	2	Q7LGA3	1
+Nonaspanin (TM9SF) [IPR004240]	0.9393939393939394	1.4801540957030623	0.1388321277418778	1.0	0.2817903851544058	3	Q99805,Q9HD45	2
+Vacuolar protein sorting-associated protein 13 [IPR026847]	0.8855604173678862	1.461972099866372	0.1437488555350548	1.0	0.2884916530271367	2	Q96RL7	1
+Nucleobindin [IPR040250]	0.8818579602827272	1.4467222095597905	0.1479747415203374	1.0	0.29468040292472	2	P80303	1
+Peptidase C13, legumain [IPR001096]	0.8808481992594991	1.4425639290436318	0.1491433506727153	1.0	0.2953151323529793	2	Q99538	1
+Nucleosome assembly protein (NAP) [IPR002164]	0.9188552188552204	1.4043038387737286	0.1602283916660165	1.0	0.3092687659588449	3	Q99733,Q01105	2
+Derlin [IPR007599]	0.8643554358801722	1.37470885681154	0.1692217243010718	1.0	0.3204998726158963	2	Q9BUN8	1
+YTH domain containing protein [IPR045168]	0.8539212386401849	1.3318639866914563	0.1829048870173033	1.0	0.3372189843377687	2	Q7Z739	1
+Torsin [IPR010448]	0.8387748232918177	1.2698351504726972	0.2041433569640123	1.0	0.3619654159672584	2	O14657	1
+Aminopeptidase N-type [IPR034016]	0.8589225589225725	1.1837530246790904	0.2365108423498028	1.0	0.4001778617680956	3	P55786,Q9UIQ6	2
+SCAMP [IPR007273]	0.848109515691716	1.144246011120316	0.2525216264062306	1.0	0.4170491105544429	3	O15127	1
+Spectrin, beta subunit [IPR016343]	0.7855940760686617	1.054639847765421	0.2915900720691147	1.0	0.4550216043981749	2	O15020	1
+THRAP3/BCLAF1 family [IPR029199]	0.7728037697744847	1.003780760747494	0.3154842997863456	1.0	0.4768046756892558	2	Q9Y2W1	1
+Tubulin [IPR000217]	0.5838395325113144	0.9508077790205736	0.3417019629562268	1.0	0.4971378182859389	6	Q13509	1
+Beta tubulin [IPR002453]	0.5838395325113144	0.9508077790205736	0.3417019629562268	1.0	0.4971378182859389	6	Q13509	1
+Ras GTPase-activating protein-binding protein [IPR039539]	0.7566475934028846	0.940229118277602	0.3471000488105999	1.0	0.5031000707479483	2	Q9UN86	1
+Inositol monophosphatase-like [IPR000760]	0.7900851151396139	0.9352645252272436	0.3496519925079735	1.0	0.5046462807073493	3	Q9NX62	1
+Peptidase M3A/M3B [IPR045090]	0.7772592602098207	0.8900347029695446	0.3734472524359105	1.0	0.5261651912751569	3	Q99797	1
+Ancient conserved domain protein family [IPR045095]	0.7421743520699962	0.8840661238650234	0.3766605188882286	1.0	0.5284114610662335	2	Q8NE01	1
+Mpv17/PMP22 [IPR007248]	0.7738522689880866	0.8780961884915965	0.3798915212422082	1.0	0.5317107367838503	3	Q567V2	1
+Major facilitator superfamily [IPR011701]	0.6901974467484282	0.8536898614728566	0.3932768531540733	1.0	0.5440309686575386	4	Q7L0J3	1
+Tumour protein D52 [IPR007327]	0.7216425445977668	0.8058768662867053	0.4203138513193343	1.0	0.5651237769331177	2	P55327	1
+HnRNP R/Q splicing factor [IPR006535]	0.7202961965668052	0.800817943785192	0.423237049425732	1.0	0.5674113330060911	2	O60506	1
+cAMP-dependent protein kinase regulatory subunit [IPR012198]	0.6718276674520255	0.6255949421530178	0.5315806571217248	1.0	0.6510180832471756	2	P10644	1
+Oxysterol-binding protein [IPR000648]	0.5326553472507918	0.5878794151821236	0.5566132342285719	1.0	0.6682812460593299	5	Q9H4L5	1
+Cyclophilin-type peptidyl-prolyl cis-trans isomerase, cyclophilin A-like [IPR044666]	0.6099268064025598	0.576042388689707	0.5645865305453288	1.0	0.6761062010965722	4	Q6UX04,Q9H2H8	2
+Proteasome B-type subunit [IPR023333]	0.470669941151953	0.5593589283965552	0.5759167857085232	1.0	0.6833310048110327	7	P49721,P20618,Q99436,P28070	4
+TB2/DP1/HVA22-related protein [IPR004345]	0.6411982497475525	0.5234298830866575	0.6006751332013365	1.0	0.6994822764761802	2	Q9H6H4	1
+Tropomyosin [IPR000533]	0.6451096503284839	0.4640048699425491	0.6426442565389414	1.0	0.7250825868238202	3	P06753	1
+Histone deacetylase [IPR003084]	0.6075395489733978	0.4209951179236451	0.6737586468466064	1.0	0.7446299752393242	2	Q13547	1
+Histone deacetylase family [IPR000286]	0.6075395489733978	0.4209951179236451	0.6737586468466064	1.0	0.7446299752393242	2	Q13547	1
+MICOS complex subunit MIC26/MIC27 [IPR019166]	0.6045102659037243	0.412348406040658	0.6800840736675009	1.0	0.7498362863513471	2	Q6UXV4	1
+MICOS complex subunit MIC26/MIC27, animal [IPR033182]	0.6045102659037243	0.412348406040658	0.6800840736675009	1.0	0.7498362863513471	2	Q6UXV4	1
+Core histone macro-H2A [IPR021171]	0.598451699764377	0.3953588084250526	0.6925781041118866	1.0	0.7603623440887947	2	Q9P0M6	1
+Heterogeneous nuclear ribonucleoprotein C [IPR017347]	0.5870077415011654	0.3644056527725149	0.7155551149457933	1.0	0.7778646895618595	2	P07910	1
+G-protein alpha subunit, group I [IPR001408]	0.5634466509592655	0.3056140584973356	0.7598985151867348	1.0	0.8126219252515422	2	P08754	1
+Dynamin [IPR022812]	0.5801346801346738	0.2985821112995545	0.7652589162638457	1.0	0.8163122202674891	3	O60313,O00429	2
+CTP synthase [IPR004468]	0.5351733423089715	0.2443788510168268	0.8069374197507861	1.0	0.8514081358089287	2	P17812	1
+Heat shock protein 70 family [IPR013126]	0.3699335155746465	0.236887621029716	0.8127439736871676	1.0	0.8566461674542002	10	P48723	1
+Ribosomal protein S11 [IPR001971]	0.5264220801077024	0.2275623077053963	0.8199865252329399	1.0	0.862713507743945	2	P82912	1
+Small GTPase, Ras-type [IPR020849]	0.4793997982553036	0.2226081235590314	0.8238405134049842	1.0	0.8659835546067783	4	P11233	1
+Ribosomal RNA adenine dimethylase [IPR011530]	0.5223830360147944	0.220145697022621	0.8257576865859793	1.0	0.8668215860093327	2	Q9UNQ2	1
+Ribosomal RNA adenine methyltransferase KsgA/Erm [IPR001737]	0.5223830360147944	0.220145697022621	0.8257576865859793	1.0	0.8668215860093327	2	Q9UNQ2	1
+Ubiquitin conjugation factor E4 [IPR045132]	0.5126220127902892	0.2031218988259117	0.8390397557131175	1.0	0.878777768500613	2	Q14139	1
+Haem oxygenase [IPR002051]	0.5092561427128823	0.1975460998522961	0.8434002096636377	1.0	0.8822738272126014	2	P30519	1
+Haem oxygenase-like [IPR016053]	0.5092561427128823	0.1975460998522961	0.8434002096636377	1.0	0.8822738272126014	2	P30519	1
+Rab GDI protein [IPR000806]	0.5031975765735239	0.1878883439997059	0.8509641801533929	1.0	0.8888613703626533	2	P31150	1
+GDP dissociation inhibitor [IPR018203]	0.5031975765735239	0.1878883439997059	0.8509641801533929	1.0	0.8888613703626533	2	P31150	1
+TAF15/EWS/TLS family [IPR034870]	0.51747077630743	0.1795107859913821	0.8575366488941516	1.0	0.8949213926886382	3	Q92804	1
+Filamin family [IPR044801]	0.5104377104377115	0.1688560598627419	0.8659098619627164	1.0	0.901485616165025	3	P21333,O75369	2
+DNA-directed RNA polymerase, subunit 2 [IPR015712]	0.4897340962638812	0.1681519491234903	0.8664637416384717	1.0	0.901485616165025	2	Q9H9Y6	1
+Protein disulphide isomerase [IPR005792]	0.5097643097643115	0.1678647720779725	0.8666896646192794	1.0	0.901485616165025	3	P30101,P13667	2
+Microtubule associated protein 1 [IPR026074]	0.4843487041400141	0.1609134455235107	0.8721615723130842	1.0	0.906111485866211	2	P46821	1
+Protein arginine N-methyltransferase [IPR025799]	0.3840970350404317	0.1533759921714562	0.8781017763386256	1.0	0.9106531150773955	5	O14744,Q99873,Q86X55,Q6P2P2	4
+Sas10/Utp3/C1D [IPR007146]	0.4692022887916369	0.1425060979326247	0.8866802630763317	1.0	0.918319166308315	2	Q9NQZ2	1
+ATPase family AAA domain-containing protein 3 [IPR039188]	0.4654998317064926	0.1384325697790543	0.8898985578466923	1.0	0.9212413960410252	2	Q5T9A4	1
+H/ACA ribonucleoprotein complex, subunit Gar1/Naf1 [IPR007504]	0.4641534836755143	0.1369917077926594	0.8910373495399129	1.0	0.9220092360212468	2	Q96HR8	1
+Microtubule-associated protein RP/EB [IPR027328]	0.4607876135981088	0.1334827170449416	0.8938116317529008	1.0	0.924349690724868	2	Q15691	1
+DnaJ homolog subfamily A member 1/2-like [IPR044713]	0.4399192191181188	0.1145745939846015	0.9087823181312796	1.0	0.9370304363680422	2	O60884	1
+RNA polymerase subunit Rpb7-like [IPR045113]	0.4372265230561842	0.112474500388855	0.910447187174618	1.0	0.9381242692412898	2	Q3B726	1
+Mesoderm induction early response protein/metastasis-associated protein [IPR040138]	0.4368899360484496	0.1122171805610534	0.910651207092966	1.0	0.9381242692412898	2	O94776	1
+Histidine phosphatase superfamily, clade-1 [IPR013078]	0.4572390572390543	0.1056261716358053	0.9158789589438638	1.0	0.9418383271335924	3	Q96HS1,Q9NQ88	2
+SNX17/27/31 [IPR037831]	0.4136654325143021	0.0970775790077069	0.9226647861101982	1.0	0.9467201207900487	2	Q96L92	1
+Chaperone DnaJ [IPR012724]	0.4400673400673241	0.0913291134026417	0.9272310855002368	1.0	0.9505653777181235	3	Q96EY1,O60884	2
+Plakin [IPR043197]	0.3468959801812944	0.0890698237109756	0.9290264192407114	1.0	0.9519855893543387	5	Q15149,P15924	2
+Cleft lip and palate transmembrane 1 [IPR008429]	0.3699091215079082	0.0800798291949305	0.936173765189268	1.0	0.9559346889927351	2	O96005	1
+Cleft lip and palate transmembrane protein 1-like protein [IPR030434]	0.3699091215079082	0.0800798291949305	0.936173765189268	1.0	0.9559346889927351	2	O96005	1
+Ezrin/radixin/moesin-like [IPR000798]	0.3264660980052861	0.0791153617651409	0.9369408648916636	1.0	0.9562974453971176	8	Q9Y2J2,P26038	2
+Succinate--CoA synthetase, beta subunit [IPR005809]	0.3493773140356748	0.0758420563783904	0.9395447563073354	1.0	0.9581128344952274	2	Q96I99	1
+Malic oxidoreductase [IPR001891]	0.3258162234937731	0.0728834338345929	0.941898876764776	1.0	0.9600918313642712	2	P48163	1
+Calreticulin/calnexin [IPR001580]	0.4047138047138059	0.0698527894059967	0.9443108298848129	1.0	0.961706029382691	3	P27824,P27797	2
+Tricarboxylate/iron carrier [IPR004686]	0.3932659932659939	0.0648755011322786	0.948273126756252	1.0	0.9640500001436152	3	Q9H9B4,Q96NB2	2
+Cell-cycle alteration and expression-elevated protein in tumour [IPR032337]	0.3511784511784492	0.0528947418745965	0.9578157739095066	1.0	0.9707761794054448	3	Q5VT52,Q9NQG5	2
+A-kinase anchoring protein 95 (AKAP95) [IPR007071]	0.3094276094276089	0.0476966569338296	0.9619579984527408	1.0	0.974549071730918	3	Q5BKZ1,O43823	2
+Ran binding protein RanBP1-like [IPR045255]	0.317952172448634	0.0452008166070688	0.9639472433589262	1.0	0.976138464491682	4	P49792,Q9H6Z4,Q9UKX7	3