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interpro_active_site/advanced/idx2term.json

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+{}

interpro_active_site/basic/idx2term.json

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+{}

interpro_active_site/consensus.joblib

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+version https://git-lfs.github.com/spec/v1
+oid sha256:41ea5b7f7be7678309b94c971b7a8b1386b534c84e71583822981b843b631bc4
+size 84099

interpro_active_site/df_merge.tsv

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+term	overlap	setsize	score	pval	overlap_mean	setsize_mean	score_mean	pval_mean	overlap_std	setsize_std	score_std	pval_std	pval_hit	pval_50	pval_100	pval_250	pval_500

interpro_active_site/metrics.json

@@ -0,0 +1,7 @@
+{
+    "type_of_task": "ranksum",
+    "signature_size": 3236,
+    "annotations_size": 53,
+    "title": "Average number of proteins per term",
+    "value": 2.641509433962264
+}

interpro_active_site/paths.json

@@ -0,0 +1 @@
+{"results_path": "results/proteins/hek293t_core/interpro_active_site/fragment/C225/C225_val_log2fc"}

interpro_active_site/result.tsv

@@ -0,0 +1,4 @@
+Term	es	nes	pval	sidak	fdr	geneset_size	leading_edge	leading_edge_size
+Histidine acid phosphatase active site [IPR033379]	0.9452690166975954	2.4404392849223036	0.0146694115991126	0.543075807671714	0.032394950614707	2	Q9NPH0	1
+Serine carboxypeptidase, serine active site [IPR018202]	0.9573151871326904	2.205115444610725	0.0274459945678235	0.7712150134893436	0.050159921106712	3	Q9H3G5,Q9HB40	2
+Cysteine peptidase, asparagine active site [IPR025661]	0.7609771181199945	1.6020992800202702	0.1091336572020642	0.9978119097660204	0.1701201126973354	2	P53634	1

interpro_active_site/selections.json

@@ -0,0 +1 @@
+{"all_annotations": ["ATP synthase, F0 complex, subunit A, active site [IPR023011]", "ATP-citrate lyase/succinyl-CoA ligase, active site [IPR017440]", "ATP:guanido phosphotransferase active site [IPR022415]", "ATPase, alpha/beta subunit, nucleotide-binding domain, active site [IPR020003]", "Adenylosuccinate synthase,  active site [IPR033128]", "Beta-ketoacyl synthase, active site [IPR018201]", "Citrate synthase active site [IPR019810]", "ClpP, Ser active site [IPR018215]", "ClpP, histidine active site [IPR033135]", "Cysteine peptidase, asparagine active site [IPR025661]", "Cysteine peptidase, cysteine active site [IPR000169]", "Cysteine peptidase, histidine active site [IPR025660]", "DNA methylase, C-5 cytosine-specific, active site [IPR018117]", "DNA topoisomerase I, active site [IPR018521]", "Ferrochelatase, active site [IPR019772]", "Glucose-6-phosphate dehydrogenase, active site [IPR019796]", "Glyceraldehyde 3-phosphate dehydrogenase, active site [IPR020830]", "Glycoside hydrolase, family 2, active site [IPR023232]", "Glycosyl hydrolases family 31, active site [IPR030458]", "Histidine acid phosphatase active site [IPR033379]", "Hydroxymethylglutaryl-CoA lyase, active site [IPR000138]", "Hydroxymethylglutaryl-coenzyme A synthase, active site [IPR000590]", "L-lactate dehydrogenase, active site [IPR018177]", "Malate dehydrogenase, active site [IPR001252]", "Nucleoside diphosphate kinase, active site [IPR023005]", "Orotidine 5'-phosphate decarboxylase, active site [IPR018089]", "Peptidase S16, active site [IPR008268]", "Peptidase S26A, signal peptidase I, serine active site [IPR019756]", "Peptidase S8, subtilisin, His-active site [IPR022398]", "Peptidase S8, subtilisin, Ser-active site [IPR023828]", "Peptidase S9, serine active site [IPR002471]", "Peptidase family C14A, His active site [IPR016129]", "Peptidase family C14A, cysteine active site [IPR033139]", "Phosphoglycerate/bisphosphoglycerate mutase, active site [IPR001345]", "Phosphoribosylglycinamide formyltransferase, active site [IPR001555]", "Protein-tyrosine phosphatase, active site [IPR016130]", "Pyridine nucleotide-disulphide oxidoreductase, class I, active site [IPR012999]", "Pyruvate kinase, active site [IPR018209]", "Ribonuclease T2, His active site 1 [IPR018188]", "Ribonuclease T2, His active site 2 [IPR033130]", "Ribonucleotide reductase small subunit, acitve site [IPR030475]", "Serine carboxypeptidase, serine active site [IPR018202]", "Serine carboxypeptidases, histidine active site [IPR033124]", "Serine/threonine-protein kinase, active site [IPR008271]", "Thermonuclease active site [IPR002071]", "Thiolase, active site [IPR020610]", "Thiolase, acyl-enzyme intermediate active site [IPR020615]", "Thymidylate synthase, active site [IPR020940]", "Transaldolase, active site [IPR018225]", "Triosephosphate isomerase, active site [IPR020861]", "Tyrosine-protein kinase, active site [IPR008266]", "Ubiquitin-activating enzyme E1, Cys active site [IPR033127]", "Ubiquitin-conjugating enzyme, active site [IPR023313]"], "available_proteins": ["ACAA1", "ACAA2", "ACAT1", "ACAT2", "ACLY", "ACP2", "ACP6", "ADSS", "AKT2", "APEH", "ATP5A1", "ATP5B", "ATP6", "ATP6V1A", "ATP6V1B2", "AURKB", "BLMH", "CAMK1", "CAMK2G", "CAPN1", "CASP7", "CDK1", "CDK11B", "CDK12", "CDK2", "CDK4", "CDK5", "CDK6", "CDK9", "CHUK", "CIT", "CKB", "CKMT1A*", "CLPP", "CPVL", "CS", "CSK", "CSNK1A1", "CSNK2A2", "CTSA", "CTSC", "CTSZ", "DLD", "DNMT1", "DUSP3", "EIF2AK2", "EPHA7", "FASN", "FECH", "G6PD", "GAA", "GAK", "GANAB", "GAPDH", "GART", "GSK3A", "GSK3B", "GSR", "GUSB", "HADHB", "HMGCL", "HMGCS1", "IGF1R", "IKBKB", "LDHA", "LDHB", "LONP1", "LYN", "MAP2K1", "MAP2K2", "MAP4K4", "MAPK1", "MAPK3", "MASTL", "MDH1", "MDH2", "NEK9", "NME1", "PAK2", "PBK", "PGAM1", "PIK3R4", "PKM", "PKMYT1", "PKN1", "PKN2", "PLK1", "PREP", "PRKACA", "PRKCA", "PRPF4B", "PTK2", "PTK7", "PTPMT1", "PTPN1", "PTPN11", "PTPRF", "PTPRS", "RNASET2", "ROCK2", "RPS6KA1", "RPS6KA3", "RRM2", "SCP2", "SCPEP1", "SEC11A", "SLK", "SND1", "SRPK1", "SUCLG1", "TALDO1", "TIGAR", "TOP1", "TPI1", "TPP2", "TTK", "TXNRD1", "TYMS", "UBA1", "UBA2", "UBA3", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UMPS", "VRK1", "VRK2", "WNK1"], "leading_proteins": ["ACP6", "CPVL", "CTSC", "SCPEP1"]}

interpro_binding_site/advanced/idx2term.json

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+{}

interpro_binding_site/basic/idx2term.json

@@ -0,0 +1 @@
+{"0": "EF-Hand 1, calcium-binding site [IPR018247]"}

interpro_binding_site/consensus.joblib

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+version https://git-lfs.github.com/spec/v1
+oid sha256:3c9e28544d5baab9a5ed3c9e35b414ce79e83878464a90cfcbf018f18362023b
+size 76425

interpro_binding_site/df_merge.tsv

@@ -0,0 +1 @@
+term	overlap	setsize	score	pval	overlap_mean	setsize_mean	score_mean	pval_mean	overlap_std	setsize_std	score_std	pval_std	pval_hit	pval_50	pval_100	pval_250	pval_500

interpro_binding_site/metrics.json

@@ -0,0 +1,7 @@
+{
+    "type_of_task": "ranksum",
+    "signature_size": 3236,
+    "annotations_size": 32,
+    "title": "Average number of proteins per term",
+    "value": 4.65625
+}

interpro_binding_site/paths.json

@@ -0,0 +1 @@
+{"results_path": "results/proteins/hek293t_core/interpro_binding_site/fragment/C225/C225_val_log2fc"}

interpro_binding_site/result.tsv

@@ -0,0 +1,4 @@
+Term	es	nes	pval	sidak	fdr	geneset_size	leading_edge	leading_edge_size
+Beta tubulin, autoregulation binding site [IPR013838]	0.7536366450015478	1.6120040116125154	0.1069610667725955	0.9732174099120268	0.201338478630768	5	P04350,Q9BVA1,Q9BUF5,P07437	4
+EF-Hand 1, calcium-binding site [IPR018247]	0.4230329086745312	1.4259263041677823	0.1538896157113178	0.9952393658753808	0.2310389505062227	39	O43852,Q9BRK5,P41208,Q9Y680,Q02818,Q96AY3,P80303,Q14257,Q9NWM8,O95202,P0DP25	11
+Peptidase M16, zinc-binding site [IPR001431]	0.3571080575138739	0.0505956667674141	0.9596477158234172	1.0	0.9596477158234172	5	Q10713	1

interpro_binding_site/selections.json

@@ -0,0 +1 @@
+{"all_annotations": ["2-oxo acid dehydrogenase, lipoyl-binding site [IPR003016]", "2Fe-2S ferredoxin, iron-sulphur binding site [IPR006058]", "6-phosphogluconate-binding site [IPR006184]", "AP endonuclease 1, binding site [IPR020847]", "APOBEC/CMP deaminase, zinc-binding [IPR016192]", "Aconitase family, 4Fe-4S cluster binding site [IPR018136]", "Adenylosuccinate synthase, GTP-binding site [IPR018220]", "Aminotransferase class-V, pyridoxal-phosphate binding site [IPR020578]", "Aminotransferase, class-II, pyridoxal-phosphate binding site [IPR001917]", "Aminotransferases, class-I, pyridoxal-phosphate-binding site [IPR004838]", "Beta tubulin, autoregulation binding site [IPR013838]", "Biotin-binding site [IPR001882]", "Copper centre Cu(A) [IPR001505]", "Cytochrome b5, heme-binding site [IPR018506]", "Cytochrome c oxidase, subunit Vb, zinc binding site [IPR020893]", "EF-Hand 1, calcium-binding site [IPR018247]", "Fumarate reductase/succinate dehydrogenase, FAD-binding site [IPR003952]", "Hexokinase, binding site [IPR019807]", "IQ motif, EF-hand binding site [IPR000048]", "Inositol monophosphatase, metal-binding site [IPR020583]", "Legume lectin, beta chain, Mn/Ca-binding site [IPR019825]", "Manganese/iron superoxide dismutase, binding site [IPR019833]", "PPM-type phosphatase, divalent cation binding [IPR000222]", "Peptidase M16, zinc-binding site [IPR001431]", "Peptidase M24A, methionine aminopeptidase, subfamily 2, binding site [IPR018349]", "Porphobilinogen deaminase, dipyrromethane cofactor binding site [IPR022419]", "Protein kinase, ATP binding site [IPR017441]", "RNA polymerases, subunit N, zinc binding site [IPR020789]", "Serine hydroxymethyltransferase, pyridoxal phosphate binding site [IPR019798]", "Sigma-54 interaction domain, ATP-binding site 1 [IPR025662]", "Transketolase binding site [IPR020826]", "Ureohydrolase, manganese-binding site [IPR020855]"], "available_proteins": ["ACACA", "ACO1", "ACO2", "ACTN1", "ACTN4", "ADSS", "AKT2", "APEX1", "ARG2", "AURKB", "BPNT1", "CALM3", "CALU", "CAMK1", "CAMK2G", "CAPN1", "CAPNS1", "CDK1", "CDK12", "CDK2", "CDK4", "CDK5", "CDK6", "CDK9", "CETN2", "CHUK", "CIT", "COX2", "COX5B", "CSK", "CSNK1A1", "CSNK2A2", "CYB5B", "DBT", "DCTD", "DLAT", "DLST", "DST", "EHD1", "EHD4", "EIF2AK2", "EPHA7", "EPS15", "FKBP10", "FKBP14", "FKBP7", "FKBP9", "GCAT", "GOT1", "GOT2", "GPD2", "GSK3A", "GSK3B", "HASPIN", "HK1", "HK2", "HMBS", "IDE", "IGF1R", "ILKAP", "IMPA1", "IQGAP1", "IQGAP2", "IQGAP3", "LETM1", "LPCAT2", "LRP2", "LYN", "MACF1", "MAP2K1", "MAP2K2", "MAP4K4", "MAPK1", "MAPK14", "MAPK3", "MCCC1", "METAP2", "MICU1", "MYH10", "MYH14", "MYH9", "MYO18A", "MYO1B", "MYO1C", "MYO1D", "MYO5A", "NRDC", "NUCB1", "NUCB2", "PA2G4", "PAK2", "PC", "PCCA", "PDCD6", "PDHX", "PEF1", "PGD", "PKMYT1", "PKN1", "PKN2", "PLCG1", "PLK1", "PLS1", "PLS3", "PMPCA", "PMPCB", "POLR2L", "PPM1G", "PRKACA", "PRKCA", "PRKCSH", "PSAT1", "PTK2", "RAB18", "RCN1", "RCN2", "REPS1", "RHOT1", "RHOT2", "ROCK2", "RPS6KA1", "RPS6KA3", "S100A11", "SDF4", "SDHA", "SDHB", "SHMT1", "SHMT2", "SLC25A12", "SLC25A24", "SLK", "SOD2", "SPTAN1", "SPTLC2", "SRI", "SRPK1", "STK26", "STK3", "STK4", "TKT", "TTK", "TUBB", "TUBB2A", "TUBB2B", "TUBB4A", "TUBB6", "UBE3C", "UQCRC2", "VRK1"], "leading_proteins": ["CALM3", "CALU", "CETN2", "FKBP10", "FKBP14", "FKBP7", "LETM1", "NUCB1", "NUCB2", "PMPCA", "RCN2", "SDF4", "TUBB", "TUBB2B", "TUBB4A", "TUBB6"]}

interpro_conserved_site/advanced/idx2term.json

@@ -0,0 +1 @@
+{}

interpro_conserved_site/basic/idx2term.json

@@ -0,0 +1 @@
+{"0": "Intermediate filament protein, conserved site [IPR018039]", "1": "Short-chain dehydrogenase/reductase, conserved site [IPR020904]"}

interpro_conserved_site/consensus.joblib

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+version https://git-lfs.github.com/spec/v1
+oid sha256:90c2c367e068a741d4bce40f93297916b6ace71b2b3ba52e7538fc1a07f02eaa
+size 120992

interpro_conserved_site/df_merge.tsv

@@ -0,0 +1 @@
+term	overlap	setsize	score	pval	overlap_mean	setsize_mean	score_mean	pval_mean	overlap_std	setsize_std	score_std	pval_std	pval_hit	pval_50	pval_100	pval_250	pval_500

interpro_conserved_site/metrics.json

@@ -0,0 +1,7 @@
+{
+    "type_of_task": "ranksum",
+    "signature_size": 3236,
+    "annotations_size": 286,
+    "title": "Average number of proteins per term",
+    "value": 2.695804195804196
+}

interpro_conserved_site/paths.json

@@ -0,0 +1 @@
+{"results_path": "results/proteins/hek293t_core/interpro_conserved_site/fragment/C225/C225_val_log2fc"}

interpro_conserved_site/result.tsv

@@ -0,0 +1,27 @@
+Term	es	nes	pval	sidak	fdr	geneset_size	leading_edge	leading_edge_size
+Haem oxygenase conserved site [IPR018207]	0.9817563388991988	2.5997747120117456	0.0093284979998	0.9314692238464906	0.0342044926659335	2	P30519	1
+Lysosome-associated membrane glycoprotein, conserved site [IPR018134]	0.9220779220779296	2.337914695938136	0.0193916737554757	0.9963039752391938	0.0577710280631882	2	P13473	1
+Tetraspanin, conserved site [IPR018503]	0.9873182802350748	2.326736197134144	0.0199793100627019	0.996886277343021	0.0589080688446675	3	O60637,Q9H1Z9	2
+Syntaxin/epimorphin, conserved site [IPR006012]	0.7954299213573762	1.951865846656541	0.0509541340860932	0.9999996807435428	0.1189199905354521	6	Q86Y82,Q9P2W9,O15400	3
+Sterol reductase, conserved site [IPR018083]	0.8682248798275571	1.8361302649272029	0.0663383931673895	0.9999999970201312	0.1390487825887826	3	O76062	1
+Sulfatase, conserved site [IPR024607]	0.8567893597277928	1.7879977321905265	0.073776373708807	0.9999999996974936	0.1476044582614522	3	P15289,P15586	2
+Glycoside hydrolase, family 29, conserved site [IPR018526]	0.7993197278911754	1.7803590878602975	0.0750172127534578	0.9999999997938306	0.1489925197742287	2	Q9BTY2	1
+Immunoglobulin/major histocompatibility complex, conserved site [IPR003006]	0.835446953294152	1.6977687369704757	0.0895514186190702	0.9999999999977764	0.1707447048336939	3	P55899,P04439	2
+Guanylate kinase, conserved site [IPR020590]	0.7214425353764404	1.6220841449269487	0.1047853325162546	0.999999999999982	0.1921064429464669	6	Q9NZW5,Q00013,Q14168,Q5T2T1	4
+Tubulin, conserved site [IPR017975]	0.7536366450015478	1.6120040116125154	0.1069610667725955	0.9999999999999912	0.1948462745029447	5	P04350,Q9BVA1,Q9BUF5,P07437	4
+Quinone oxidoreductase/zeta-crystallin, conserved site [IPR002364]	0.7758135546961887	1.541069532416662	0.1232998641021234	1.0	0.2079076681263423	4	Q8WWV3,Q8N4Q0	2
+EGF-like calcium-binding, conserved site [IPR018097]	0.7486555181719128	1.424432353452374	0.1543213542024784	1.0	0.2451994850106045	4	O94813	1
+Low-density lipoprotein (LDL) receptor class A, conserved site [IPR023415]	0.7169484584248562	1.2877169870045426	0.197844498172516	1.0	0.2815100819768139	4	P01130	1
+Proteasome beta-type subunit, conserved site [IPR016050]	0.5695563857098841	1.1396947786005605	0.254413483239384	1.0	0.3384290986347155	8	P28074,P28072,P49721	3
+Intermediate filament protein, conserved site [IPR018039]	0.5303593556381551	0.9403318107973988	0.3470473873310413	1.0	0.4223640543688418	8	P48681,Q03252,P20700,P07196,P02545,Q16352,P08670	7
+AMP-binding, conserved site [IPR020845]	0.5434838139839191	0.922069033882346	0.3564925679834636	1.0	0.4283902287532378	7	Q9UKU0	1
+S100/Calbindin-D9k, conserved site [IPR001751]	0.5779220779220721	0.7606612820772084	0.4468594062850155	1.0	0.5195194723476197	2	P60903	1
+ABC transporter-like, conserved site [IPR017871]	0.4349027162527662	0.6611164783259114	0.5085376184381472	1.0	0.5726053498949216	11	O75027,P33527,Q03518,P08183	4
+Clathrin adaptor complex, small chain [IPR000804]	0.5528756957328321	0.6543531926955107	0.5128842831626779	1.0	0.5747526714113405	2	P53680	1
+Phosphatidylinositol 3/4-kinase, conserved site [IPR018936]	0.4812751470133211	0.4296919262591908	0.6674197572504619	1.0	0.7171729422913381	5	P78527,P42356,Q9UBF8,P42345	4
+Guanine-nucleotide dissociation stimulator, CDC24, conserved site [IPR001331]	0.4941249226963438	0.4267950859923777	0.6695285859852702	1.0	0.7171729422913381	2	Q14155	1
+Short-chain dehydrogenase/reductase, conserved site [IPR020904]	0.3887986557394273	0.3998844253111614	0.6892416441606093	1.0	0.7327996662822835	11	Q8NBN7,Q06136,Q6YN16,Q53GQ0,Q6IAN0	5
+Thioredoxin, conserved site [IPR017937]	0.378102836080273	0.3417506843515759	0.7325385254652672	1.0	0.7702427142759795	11	Q96JJ7,Q9H1E5,Q9H3N1	3
+Dynamin, GTPase region, conserved site [IPR019762]	0.4726260439220582	0.2628543579480477	0.7926628366001833	1.0	0.8243693500641907	3	Q9UQ16,P50570	2
+Cadherin conserved site [IPR020894]	0.4287039901020771	0.1548723590398779	0.8769219449846406	1.0	0.9021571088690908	3	Q14126,Q14574	2
+Isocitrate/isopropylmalate dehydrogenase, conserved site [IPR019818]	0.4074876237623858	0.1287276705525501	0.8975731396333901	1.0	0.9168068497683912	4	O75874,O43837,P48735	3

interpro_conserved_site/selections.json

@@ -0,0 +1 @@
+{"all_annotations": ["14-3-3 protein, conserved site [IPR023409]", "3-hydroxyacyl-CoA dehydrogenase, conserved site [IPR006180]", "3-hydroxyisobutyrate dehydrogenase-related, conserved site [IPR002204]", "4Fe-4S ferredoxin, iron-sulphur binding, conserved site [IPR017900]", "ABC transporter-like, conserved site [IPR017871]", "AMP-binding, conserved site [IPR020845]", "AP endonuclease 1, conserved site [IPR020848]", "AT hook, DNA-binding motif [IPR017956]", "ATP synthase, F1 complex, gamma subunit conserved site [IPR023632]", "ATP-citrate lyase/succinyl-CoA ligase, conserved site [IPR033847]", "ATP-dependent RNA helicase DEAD-box, conserved site [IPR000629]", "ATPase, AAA-type, conserved site [IPR003960]", "ATPase, OSCP/delta subunit, conserved site [IPR020781]", "Acin1, RNSP1-SAP18 binding (RSB) motif [IPR032552]", "Actin, conserved site [IPR004001]", "Actin/actin-like conserved site [IPR020902]", "Actinin-type actin-binding domain, conserved site [IPR001589]", "Acyl-CoA dehydrogenase, conserved site [IPR006089]", "Acyl-CoA-binding protein, ACBP, conserved site [IPR022408]", "Adenylate kinase, conserved site [IPR033690]", "Alanine dehydrogenase/NAD(P) transhydrogenase, conserved site-1 [IPR008142]", "Alanine dehydrogenase/pyridine nucleotide transhydrogenase, conserved site-2 [IPR008143]", "Alcohol dehydrogenase, zinc-type, conserved site [IPR002328]", "Aldehyde dehydrogenase, cysteine active site [IPR016160]", "Aldehyde dehydrogenase, glutamic acid active site [IPR029510]", "Aldo/keto reductase, conserved site [IPR018170]", "Aldose 1-epimerase, conserved site [IPR018052]", "Alpha-2-macroglobulin, conserved site [IPR019742]", "Alpha-D-phosphohexomutase, conserved site [IPR016066]", "Aminoacyl-tRNA synthetase, class I, conserved site [IPR001412]", "Aminotransferase, class IV, conserved site [IPR018300]", "Amyloidogenic glycoprotein,  copper-binding domain conserved site [IPR019744]", "Amyloidogenic glycoprotein, intracellular domain, conserved site [IPR019745]", "Anion exchange, conserved site [IPR018241]", "Annexin repeat, conserved site [IPR018252]", "Apoptosis regulator, Bcl-2, BH1 motif, conserved site [IPR020717]", "Apoptosis regulator, Bcl-2, BH2 motif, conserved site [IPR020726]", "Apoptosis regulator, Bcl-2, BH3 motif, conserved site [IPR020728]", "ArgE/DapE/ACY1/CPG2/YscS, conserved site [IPR001261]", "Arrestin, conserved site [IPR017864]", "BUD31/G10-related, conserved site [IPR018230]", "Bacterial Fmu (Sun)/eukaryotic nucleolar NOL1/Nop2p, conserved site [IPR018314]", "Band 7/stomatin-like, conserved site [IPR018080]", "Bax inhibitor 1, conserved site [IPR006213]", "Bromodomain, conserved site [IPR018359]", "C-type lectin, conserved site [IPR018378]", "CAP, conserved site, C-terminal [IPR028417]", "CAP, conserved site, N-terminal [IPR018106]", "CBX family C-terminal motif [IPR033773]", "Cadherin conserved site [IPR020894]", "Calreticulin/calnexin, conserved site [IPR018124]", "Carbohydrate/purine kinase, PfkB, conserved site [IPR002173]", "Chaperonin Cpn60, conserved site [IPR018370]", "Chaperonin GroES, conserved site [IPR018369]", "Chaperonin TCP-1, conserved site [IPR002194]", "Chromo domain, conserved site [IPR023779]", "Clathrin adaptor complex, small chain [IPR000804]", "Clathrin adaptor, mu subunit, conserved site [IPR018240]", "Clusterin, conserved site [IPR033986]", "Copper type II, ascorbate-dependent monooxygenase, histidine-cluster-1 conserved site [IPR020611]", "Copper type II, ascorbate-dependent monooxygenase, histidine-cluster-2 conserved site [IPR014783]", "Coproporphyrinogen III oxidase, conserved site [IPR018375]", "Cullin, conserved site [IPR016157]", "Cyclic nucleotide-binding, conserved site [IPR018488]", "Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site [IPR020892]", "Cytochrome P450, conserved site [IPR017972]", "D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site 1 [IPR029752]", "D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site [IPR029753]", "DNA ligase, ATP-dependent, conserved site [IPR016059]", "DNA methylase, C-5 cytosine-specific,  conserved site [IPR031303]", "DNA methylase, N-6 adenine-specific, conserved site [IPR002052]", "DNA mismatch repair, conserved site [IPR014762]", "DNA topoisomerase, type IIA, conserved site [IPR018522]", "DNA-directed DNA polymerase, family A, conserved site [IPR019760]", "DNA-directed DNA polymerase, family B, conserved site [IPR017964]", "DNA-directed RNA polymerase, 30-40kDa subunit, conserved site [IPR001514]", "DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site [IPR002464]", "Dihydrofolate reductase conserved site [IPR017925]", "Dihydroorotase, conserved site [IPR002195]", "DnaJ domain, conserved site [IPR018253]", "Dpy-30 motif [IPR007858]", "Dynamin, GTPase region, conserved site [IPR019762]", "Dynein light chain, type 1/2, conserved site [IPR019763]", "EGF-like calcium-binding, conserved site [IPR018097]", "EGF-like, conserved site [IPR013032]", "Electron transfer flavoprotein subunit alpha, conserved site [IPR018206]", "Electron transfer flavoprotein, beta-subunit, conserved site [IPR000049]", "Enolase, conserved site [IPR020809]", "Enoyl-CoA hydratase/isomerase, conserved site [IPR018376]", "Ependymin, conserved site [IPR018224]", "Eukaryotic translation initiation factor 4E (eIF-4E), conserved site [IPR019770]", "F-actin capping protein, alpha subunit, conserved site [IPR017865]", "F-actin capping protein, beta subunit, conserved site [IPR019771]", "FERM conserved site [IPR019747]", "FLAP/GST2/LTC4S, conserved site [IPR018295]", "Fatty acid desaturase type 1, conserved site [IPR001522]", "Ferritin, conserved site [IPR014034]", "Fibrillarin, conserved site [IPR020813]", "Fork head domain conserved site 2 [IPR030456]", "Fork head domain conserved site1 [IPR018122]", "Formate-tetrahydrofolate ligase, FTHFS, conserved site [IPR020628]", "Fructose-bisphosphate aldolase class-I active site [IPR029768]", "Fumarate lyase, conserved site [IPR020557]", "GHMP kinase, ATP-binding, conserved site [IPR006203]", "GTP1/OBG, conserved site [IPR006074]", "Galactokinase, conserved site [IPR019741]", "Gamma-glutamyl phosphate reductase GPR, conserved site [IPR020593]", "Glucosamine-6-phosphate isomerase, conserved site [IPR018321]", "Glutamate 5-kinase, conserved site [IPR019797]", "Glutamyl-tRNA(Gln) amidotransferase, subunit B, conserved site [IPR017958]", "Glutathione peroxidase conserved site [IPR029760]", "Glycoside hydrolase family 27/36, conserved site [IPR000111]", "Glycoside hydrolase, family 2, conserved site [IPR023230]", "Glycoside hydrolase, family 29, conserved site [IPR018526]", "Glycoside hydrolase, family 35, conserved site [IPR019801]", "Glycosyl hydrolases family 31, conserved site [IPR030459]", "Glyoxalase I, conserved site [IPR018146]", "Golgin subfamily A member 2, C-terminal binding motif [IPR043937]", "Guanine-nucleotide dissociation stimulator, CDC24, conserved site [IPR001331]", "Guanylate kinase, conserved site [IPR020590]", "HIND motif [IPR045347]", "HMG box A DNA-binding domain, conserved site [IPR017967]", "HMG-I/HMG-Y, DNA-binding, conserved site [IPR000637]", "Haem oxygenase conserved site [IPR018207]", "Heat shock protein 70, conserved site [IPR018181]", "Heat shock protein Hsp90, conserved site [IPR019805]", "Heavy-metal-associated, conserved site [IPR017969]", "Helix-hairpin-helix motif, class 2 [IPR008918]", "Hexapeptide transferase, conserved site [IPR018357]", "Histidine triad, conserved site [IPR019808]", "Histone H2A conserved site [IPR032458]", "Histone H4, conserved site [IPR019809]", "IMP dehydrogenase / GMP reductase, conserved site [IPR015875]", "Immunoglobulin/major histocompatibility complex, conserved site [IPR003006]", "Inositol monophosphatase, conserved site [IPR020550]", "Integrin alpha chain, C-terminal cytoplasmic region, conserved site [IPR018184]", "Intermediate filament protein, conserved site [IPR018039]", "Isocitrate/isopropylmalate dehydrogenase, conserved site [IPR019818]", "Kinesin motor domain, conserved site [IPR019821]", "Lipocalin family conserved site [IPR022272]", "Low-density lipoprotein (LDL) receptor class A, conserved site [IPR023415]", "Lysophospholipase patatin, conserved site [IPR001423]", "Lysosome-associated membrane glycoprotein, conserved site [IPR018134]", "Macrophage migration inhibitory factor, conserved site [IPR019829]", "Malic enzyme, conserved site [IPR015884]", "Methylthiotransferase, conserved site [IPR020612]", "Mini-chromosome maintenance, conserved site [IPR018525]", "Mitogen-activated protein (MAP) kinase, conserved site [IPR003527]", "MnmG-related, conserved site [IPR020595]", "Mrp, conserved site [IPR000808]", "Myristoyl-CoA:protein N-myristoyltransferase, conserved site [IPR022678]", "NADH:ubiquinone oxidoreductase, 30kDa subunit, conserved site [IPR020396]", "NADH:ubiquinone oxidoreductase, 49kDa subunit, conserved site [IPR014029]", "NADH:ubiquinone oxidoreductase, 51kDa subunit, conserved site [IPR001949]", "NADH:ubiquinone oxidoreductase, 75kDa subunit, conserved site [IPR000283]", "NADH:ubiquinone oxidoreductase, subunit 1, conserved site [IPR018086]", "NUDIX hydrolase, conserved site [IPR020084]", "Oxysterol-binding protein, conserved site [IPR018494]", "P-type trefoil, conserved site [IPR017957]", "Peptidase M22, conserved site [IPR017860]", "Peptidase M24B, X-Pro dipeptidase/aminopeptidase P, conserved site [IPR001131]", "Peptidase S26A, signal peptidase I, conserved site [IPR019758]", "Peptidyl-prolyl cis-trans isomerase, PpiC-type, conserved site [IPR023058]", "Phosphatidylethanolamine-binding, conserved site [IPR001858]", "Phosphatidylinositol 3/4-kinase, conserved site [IPR018936]", "Phosphoenolpyruvate carboxykinase, GTP-utilising, conserved site [IPR018091]", "Phosphofructokinase, conserved site [IPR015912]", "Phosphoglucose isomerase, conserved site [IPR018189]", "Phosphoglycerate kinase, conserved site [IPR015911]", "Phosphomannose isomerase, type I, conserved site [IPR018050]", "Phosphoribosyl pyrophosphate synthetase, conserved site [IPR000842]", "Phosphoribosylglycinamide synthetase, conserved site [IPR020559]", "Phosphorylase pyridoxal-phosphate attachment site [IPR035090]", "Polyamine biosynthesis domain, conserved site [IPR030373]", "Polyprenyl synthetase, conserved site [IPR033749]", "Procollagen-lysine 5-dioxygenase, conserved site [IPR001006]", "Profilin conserved site [IPR027310]", "Proliferating cell nuclear antigen, PCNA, conserved site [IPR022659]", "Proteasome beta-type subunit, conserved site [IPR016050]", "Protein phosphatase 2A regulatory subunit PR55, conserved site [IPR018067]", "Proteinase inhibitor I2, Kunitz, conserved site [IPR020901]", "Proteinase inhibitor I25, cystatin, conserved site [IPR018073]", "Pseudouridine synthase TruD, conserved site [IPR020119]", "Purine phosphorylase, family 2, conserved site [IPR018099]", "Quinone oxidoreductase/zeta-crystallin, conserved site [IPR002364]", "RNA 3'-terminal phosphate cyclase-like, conserved site [IPR020719]", "RNA polymerase, beta subunit, conserved site [IPR007121]", "Ras GTPase-activating protein, conserved site [IPR023152]", "Retro-transposon transporting motif [IPR018892]", "Ribonuclease II/R, conserved site [IPR022966]", "Ribosomal RNA adenine methylase transferase, conserved site [IPR020596]", "Ribosomal S11, conserved site [IPR018102]", "Ribosomal S24e conserved site [IPR018098]", "Ribosomal protein L1, conserved site [IPR023673]", "Ribosomal protein L10e, conserved site [IPR018255]", "Ribosomal protein L11, conserved site [IPR020785]", "Ribosomal protein L13, conserved site [IPR023563]", "Ribosomal protein L13e, conserved site [IPR018256]", "Ribosomal protein L14P,  conserved site [IPR019972]", "Ribosomal protein L15, conserved site [IPR001196]", "Ribosomal protein L15e, conserved site [IPR020925]", "Ribosomal protein L18e, conserved site [IPR021132]", "Ribosomal protein L19/L19e conserved site [IPR023638]", "Ribosomal protein L2, conserved site [IPR022671]", "Ribosomal protein L21e, conserved site [IPR018259]", "Ribosomal protein L22/L17, conserved site [IPR018260]", "Ribosomal protein L23/L25, conserved site [IPR001014]", "Ribosomal protein L24/L26, conserved site [IPR005825]", "Ribosomal protein L24e, conserved site [IPR023442]", "Ribosomal protein L27e, conserved site [IPR018262]", "Ribosomal protein L29, conserved site [IPR018254]", "Ribosomal protein L3, conserved site [IPR019926]", "Ribosomal protein L30, conserved site [IPR018038]", "Ribosomal protein L30e, conserved site [IPR022991]", "Ribosomal protein L31e, conserved site [IPR020052]", "Ribosomal protein L32e, conserved site [IPR018263]", "Ribosomal protein L34e, conserved site [IPR018065]", "Ribosomal protein L35Ae, conserved site [IPR018266]", "Ribosomal protein L37e, conserved site [IPR018267]", "Ribosomal protein L4/L1e, eukaryotic/archaeal, conserved site [IPR013000]", "Ribosomal protein L5, conserved site [IPR020929]", "Ribosomal protein L6, conserved site-2 [IPR002359]", "Ribosomal protein L7Ae conserved site [IPR004037]", "Ribosomal protein S10, conserved site [IPR018268]", "Ribosomal protein S13, conserved site [IPR018269]", "Ribosomal protein S14, conserved site [IPR018271]", "Ribosomal protein S17, conserved site [IPR019979]", "Ribosomal protein S17e, conserved site [IPR018273]", "Ribosomal protein S19 conserved site [IPR020934]", "Ribosomal protein S19e, conserved site [IPR018277]", "Ribosomal protein S2, conserved site [IPR018130]", "Ribosomal protein S28e conserved site [IPR028626]", "Ribosomal protein S3, conserved site [IPR018280]", "Ribosomal protein S3Ae, conserved site [IPR018281]", "Ribosomal protein S4, conserved site [IPR018079]", "Ribosomal protein S4e, N-terminal, conserved site [IPR018199]", "Ribosomal protein S5, N-terminal, conserved site [IPR018192]", "Ribosomal protein S6e, conserved site [IPR018282]", "Ribosomal protein S7, conserved site [IPR020606]", "Ribosomal protein S8e, conserved site [IPR018283]", "Ribosomal protein S9, conserved site [IPR020574]", "Ribosome maturation protein SBDS, conserved site [IPR018023]", "RidA, conserved site [IPR019897]", "S-adenosyl-L-homocysteine hydrolase, conserved site [IPR020082]", "S-adenosylmethionine synthetase, conserved site [IPR022631]", "S100/Calbindin-D9k, conserved site [IPR001751]", "SAICAR synthetase, conserved site [IPR018236]", "SecY conserved site [IPR030659]", "Serpin, conserved site [IPR023795]", "Short-chain dehydrogenase/reductase, conserved site [IPR020904]", "Sodium/solute symporter, conserved site [IPR018212]", "Sodium:dicarboxylate symporter, conserved site [IPR018107]", "Squalene/phytoene synthase, conserved site [IPR019845]", "Stathmin, conserved site [IPR030514]", "Sterol reductase, conserved site [IPR018083]", "Succinyl-CoA synthetase, beta subunit, conserved site [IPR017866]", "Sugar transporter, conserved site [IPR005829]", "Sulfatase, conserved site [IPR024607]", "Syntaxin/epimorphin, conserved site [IPR006012]", "TPP-binding enzyme, conserved site [IPR000399]", "Terpene synthase, conserved site [IPR002365]", "Tetrahydrofolate dehydrogenase/cyclohydrolase, conserved site [IPR020867]", "Tetraspanin, conserved site [IPR018503]", "Thiolase, conserved site [IPR020613]", "Thioredoxin, conserved site [IPR017937]", "Thiosulphate sulfurtransferase, conserved site [IPR001307]", "Thymidine kinase, conserved site [IPR020633]", "Thymidylate kinase, conserved site [IPR018095]", "Tr-type G domain, conserved site [IPR031157]", "Translation elongation factor EF1B, beta/delta chains, conserved site [IPR001326]", "Translation elongation factor Ts, conserved site [IPR018101]", "Translationally controlled tumour protein, conserved site [IPR018103]", "Tubulin, conserved site [IPR017975]", "Tyrosine-protein kinase, receptor class II, conserved site [IPR002011]", "Tyrosine-protein kinase, receptor class V, conserved site [IPR001426]", "UbiE/COQ5 methyltransferase, conserved site [IPR023576]", "Ubiquitin conserved site [IPR019954]", "Ubiquitin interacting motif [IPR003903]", "Ubiquitin specific protease, conserved site [IPR018200]", "Ubiquitin-activating enzyme E1, conserved site [IPR018074]", "Vinculin, conserved site [IPR000633]", "WD40 repeat, conserved site [IPR019775]", "XPG conserved site [IPR019974]", "Zinc finger, PHD-type, conserved site [IPR019786]", "Zinc finger, RING-type, conserved site [IPR017907]", "tRNA-dihydrouridine synthase, conserved site [IPR018517]"], "available_proteins": ["AAAS", "AAMP", "ABCB1", "ABCB10", "ABCB7", "ABCC1", "ABCC4", "ABCD3", "ABCE1", "ABCF1", "ABCF2", "ABCF3", "ACAA1", "ACAA2", "ACAD9", "ACADM", "ACADS", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACIN1", "ACLY", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACSL6", "ACTL6A", "ACTN1", "ACTN4", "ACTR1A", "ACTR2", "ACTR3", "ADH5", "ADK", "ADSL", "AFG3L2", "AHCY", "AHCYL1", "AK1", "AK2", "AK3", "AK4", "AKR1A1", "AKR1B1", "ALDH18A1", "ALDH1A2", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ANXA1", "ANXA11", "ANXA2", "ANXA6", "ANXA7", "AP1M1", "AP2M1", "AP2S1", "AP3M1", "APEX1", "APP", "ARHGEF7", "ARRB1", "ARSA", "ATAD1", "ATAD2", "ATM", "ATP5C1", "ATP5O", "ATP7B", "BAG6", "BAK1", "BAZ1A", "BAZ1B", "BCAT2", "BCR", "BCS1L", "BLM", "BOP1", "BPNT1", "BPTF", "BRCA1", "BRD2", "BUD31", "CAD", "CALR", "CANX", "CAP1", "CAPZA1", "CAPZA2", "CAPZB", "CASK", "CBR1", "CBX1", "CBX2", "CBX3", "CBX5", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD109", "CD320", "CDC40", "CDH2", "CDKAL1", "CETN2", "CHAF1B", "CHD1", "CHD1L", "CHD3", "CHD4", "CLGN", "CLU", "CMPK1", "CNDP2", "COLEC12", "COPA", "COPZ1", "CORO1B", "CORO1C", "CORO7", "CPOX", "CRYZ", "CSTB", "CSTF1", "CTBP1", "CTBP2", "CTNNA1", "CUL1", "CUL2", "CUL3", "CUL4A", "CUL4B", "CUL5", "CWC27", "CYP51A1", "DCAF13", "DCP2", "DCPS", "DCXR", "DDT", "DDX10", "DDX17", "DDX18", "DDX20", "DDX23", "DDX24", "DDX27", "DDX3X", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX51", "DDX54", "DDX6", "DHCR7", "DHFR", "DHRS7", "DHRS7B", "DHX15", "DHX16", "DHX29", "DHX30", "DHX36", "DHX38", "DHX8", "DHX9", "DIDO1", "DIMT1", "DIS3", "DLG3", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJB11", "DNAJB4", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC16", "DNAJC2", "DNAJC9", "DNM1L", "DNM2", "DNM3", "DNMT1", "DPY30", "DRG1", "DRG2", "DSC3", "DSG2", "DST", "DTYMK", "DUS2", "DYNLL1", "DYNLL2", "EARS2", "ECH1", "ECHS1", "ECI1", "ECI2", "EED", "EEF1A2", "EEF1B2", "EEF1D", "EEF2", "EHHADH", "EIF3I", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4E", "ENO1", "ENO2", "EPB41", "EPB41L2", "EPB41L3", "EPB41L5", "EPDR1", "EPHA7", "EPRS", "EPS15", "ERCC2", "ETFA", "ETFB", "EXO1", "EZR", "FBL", "FCGRT", "FDFT1", "FDPS", "FEN1", "FH", "FLNA", "FLNB", "FLNC", "FOXK2", "FTL", "FUCA1", "FUCA2", "GAA", "GALK1", "GALM", "GANAB", "GART", "GATB", "GCDH", "GEMIN5", "GFM1", "GLA", "GLB1", "GLB1L2", "GLO1", "GMPPA", "GNPDA1", "GNS", "GOLGA2", "GPI", "GPX8", "GRHPR", "GRWD1", "GSPT1", "GTF3C2", "GUF1", "GUSB", "H2AFX", "H4C1*", "HADH", "HADHA", "HADHB", "HIBADH", "HINT2", "HLA-A", "HLA-B", "HLTF", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMOX1", "HMOX2", "HSD17B10", "HSD17B12", "HSD17B4", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA13", "HSPA14", "HSPA1B", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPD1", "HSPE1", "HSPH1", "HYOU1", "IARS", "IARS2", "IDH1", "IDH2", "IDH3A", "IDH3B", "IGF1R", "ILVBL", "IMPA1", "IMPAD1", "IMPDH1", "IMPDH2", "INA", "INTS12", "IQGAP1", "IQGAP2", "IQGAP3", "ITGA6", "ITGAV", "IVD", "KATNA1", "KDM2A", "KDM5A", "KDSR", "KIF11", "KIF14", "KIF18B", "KIF1A", "KIF20A", "KIF20B", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF4A", "KIF5B", "LAMP1", "LAMP2", "LARS", "LARS2", "LBR", "LDLR", "LIG1", "LIG3", "LMNA", "LMNB1", "LMNB2", "LRP1", "LRP2", "LRWD1", "LSS", "MACF1", "MAPK1", "MAPK14", "MAPK3", "MARS", "MAT2A", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "ME1", "ME2", "MGST2", "MID1", "MIF", "MPI", "MPP1", "MPP2", "MPP6", "MPP7", "MPST", "MRC2", "MRPL13", "MRPL24", "MRPL3", "MRPS11", "MRPS2", "MRPS5", "MRPS9", "MSN", "MTAP", "MTHFD1", "MTHFD1L", "MTHFD2", "MTO1", "MTOR", "ND1", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS8", "NDUFV1", "NEFL", "NEFM", "NES", "NF1", "NLE1", "NMT1", "NNT", "NOP2", "NSD2", "NSF", "NUBP2", "NUDT1", "NUDT5", "NUP153", "NUP37", "NUP43", "NVL", "OSBP", "OSBPL11", "OSBPL1A", "OSBPL3", "OSBPL8", "OSBPL9", "OSGEP", "P4HB", "PAFAH1B1", "PAICS", "PAK1IP1", "PAM", "PBRM1", "PCK2", "PCNA", "PDIA3", "PDIA4", "PDIA6", "PEBP1", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGK1", "PGM1", "PGM2", "PHF3", "PHF8", "PHGDH", "PHIP", "PI4KA", "PI4KB", "PIN1", "PLEC", "PLOD1", "PLOD2", "PLOD3", "PLRG1", "PLS1", "PLS3", "PNP", "PNPLA6", "POLA1", "POLD1", "POLG", "POLR1B", "POLR1C", "POLR2B", "POLR2C", "POLR3B", "PPIB", "PPIC", "PPID", "PPIE", "PPIF", "PPIH", "PPIL1", "PPIL3", "PPP2R2A", "PRKAR1A", "PRKAR2A", "PRKDC", "PRPF19", "PRPF4", "PRPS2", "PSMA4", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD4", "PUS7", "PWP2", "PYGB", "PYGL", "QARS", "QDPR", "RACK1", "RAE1", "RANBP2", "RARS", "RARS2", "RASAL2", "RBBP4", "RBBP7", "RCL1", "RDH13", "RDX", "RIDA", "RNF169", "RNF2", "RNF20", "RNF40", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL15", "RPL17", "RPL18", "RPL19", "RPL21", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL37", "RPL4", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPS11", "RPS14", "RPS15", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS24", "RPS28", "RPS29", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS8", "RPS9", "RPSA", "RRP8", "RRP9", "RSF1", "RTCA", "RTN4IP1", "S100A10", "S100A11", "SART1", "SBDS", "SCAF11", "SCD", "SCP2", "SDHB", "SEC11A", "SEC61A1", "SERPINB6", "SERPINH1", "SGSH", "SLC1A5", "SLC25A42", "SLC27A2", "SLC27A4", "SLC2A1", "SLC4A2", "SLC5A6", "SLIT2", "SMARCA4", "SMS", "SMU1", "SNRNP40", "SNU13", "SPATA5", "SPATA5L1", "SPTBN1", "SPTBN2", "SRCAP", "SRM", "STAM2", "STMN1", "STOM", "STRN", "STX10", "STX12", "STX18", "STX3", "STX5", "STX7", "SUCLA2", "SUCLG1", "SUCLG2", "SV2A", "SYNE1", "SYNE2", "TAP1", "TBL3", "TCP1", "TFB1M", "TK1", "TLE3", "TLN1", "TM7SF2", "TMBIM6", "TMX1", "TMX3", "TMX4", "TOP2A", "TOP2B", "TPT1", "TRIM21", "TRIM24", "TRIM25", "TRIM28", "TRIM33", "TRIP13", "TRMT11", "TSFM", "TSPAN10", "TSPAN3", "TSPAN6", "TTF2", "TUBB", "TUBB2A", "TUBB2B", "TUBB4A", "TUBB6", "TUFM", "TXNDC12", "TXNDC5", "TXNL1", "UBA1", "UBA2", "UBA5", "UBFD1", "UHRF1", "USP10", "USP14", "USP15", "USP19", "USP24", "USP28", "USP34", "USP47", "USP48", "USP5", "USP7", "USP8", "USP9X", "UTP15", "UTP18", "UTRN", "VARS1", "VARS2", "VAT1", "VCL", "VCP", "VIM", "VPS4A", "VPS4B", "WARS", "WARS2", "WDHD1", "WDR1", "WDR11", "WDR12", "WDR18", "WDR3", "WDR36", "WDR5", "WDR61", "WDR77", "XPNPEP1", "YARS2", "YME1L1", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2", "ZMYND8"], "leading_proteins": ["ABCB1", "ABCB7", "ABCC1", "ACSL6", "AP2S1", "ARHGEF7", "ARSA", "DHRS7B", "DNM2", "DNM3", "DSC3", "DSG2", "FCGRT", "FUCA2", "GNS", "HLA-A", "HMOX2", "HSD17B12", "HSDL2", "IDH1", "IDH2", "IDH3B", "INA", "KDSR", "LAMP2", "LDLR", "LMNA", "LMNB1", "LMNB2", "MPP1", "MPP2", "MPP6", "MPP7", "MTOR", "NEFL", "NES", "PI4KA", "PI4KB", "PRKDC", "PSMB2", "PSMB5", "PSMB6", "RDH13", "RTN4IP1", "S100A10", "SLIT2", "STX12", "STX18", "STX7", "TAP1", "TM7SF2", "TMX1", "TMX3", "TMX4", "TSPAN10", "TSPAN3", "TUBB", "TUBB2B", "TUBB4A", "TUBB6", "VIM", "ZADH2"]}

interpro_domain/advanced/idx2term.json

@@ -0,0 +1 @@
+{"0": "EF-hand domain [IPR002048]", "1": "P-type ATPase, haloacid dehalogenase domain [IPR044492]", "2": "Immunoglobulin-like domain [IPR007110]"}

interpro_domain/basic/idx2term.json

@@ -0,0 +1 @@
+{"0": "EF-hand domain [IPR002048]", "1": "P-type ATPase, haloacid dehalogenase domain [IPR044492]", "2": "Immunoglobulin-like domain [IPR007110]", "3": "Band 7 domain [IPR001107]", "4": "Cytochrome b5-like heme/steroid binding domain [IPR001199]", "5": "Target SNARE coiled-coil homology domain [IPR000727]", "6": "RNA recognition motif domain, eukaryote [IPR003954]", "7": "Intermediate filament, rod domain [IPR039008]", "8": "Acyl-CoA oxidase/dehydrogenase, central domain [IPR006091]", "9": "Phosphatidylinositol 3-/4-kinase, catalytic domain [IPR000403]", "10": "Thioredoxin domain [IPR013766]", "11": "Matrin/U1-C, C2H2-type zinc finger [IPR000690]"}

interpro_domain/consensus.joblib

@@ -0,0 +1,3 @@
+version https://git-lfs.github.com/spec/v1
+oid sha256:36c5eb3e5d07106e050182bb029d6d1561fdf4974234ea79961490ca3756b024
+size 547624

interpro_domain/df_merge.tsv

@@ -0,0 +1,9 @@
+term	overlap	setsize	score	pval	overlap_mean	setsize_mean	score_mean	pval_mean	overlap_std	setsize_std	score_std	pval_std	pval_hit	pval_50	pval_100	pval_250	pval_500
+EF-hand domain [IPR002048]	18	48	2.3186327508305515	0.0204149577277121	12.385922330097088	43.512135922330096	1.0171858714399242	0.3947118087831401	4.608360476919044	4.087317384177653	1.201458704248258	0.3652478399429377	0.0015152611763406	0.0803264485172424	0.0697861672765754	0.0028229234797234	0.0087472646548666
+P-type ATPase, haloacid dehalogenase domain [IPR044492]	6	8	2.2944109617053363	0.0217669041066081	2.941747572815534	6.145631067961165	0.9567723497044874	0.2732808833570771	1.8358630293390923	1.459204245106796	1.2102525517005158	0.2943240638910574	0.0026147713450664	1.0	0.1898352204968973	0.0152248647419399	0.0004763398606397
+TRAM/LAG1/CLN8 homology domain [IPR006634]	3	5	2.1449480970731587	0.0319569970670192	1.691747572815534	3.3592233009708736	1.3447142040916915	0.1822595206051251	1.014281444620711	0.9789470163478144	1.2723870690026748	0.2262567589818981	9.70048072649134e-05	0.0461123069087121	0.0038356556834428	6.194004931981708e-05	5.331497427737023e-05
+Phospholipid/glycerol acyltransferase [IPR002123]	3	9	2.0884339428702674	0.0367587083199867	2.4611650485436893	6.109223300970874	0.4541526786138767	0.3733328307275969	1.647577392422315	1.6678607828333205	1.200305691546449	0.3080828121567173	0.008459922663953	0.0727733471903131	0.1419203898220533	0.0557098434243155	0.0393335136754485
+LEM domain [IPR003887]	2	6	2.041202345283069	0.0412307187048948	2.237864077669903	5.759708737864078	0.8787481060627674	0.3228260833428172	1.2758866328838632	0.4653299410110203	1.033781091163317	0.2887768895441466	0.0101908497095879	1.0	1.0	0.0081566962170519	0.0020138995360532
+GOLD domain [IPR009038]	4	6	2.002116441218129	0.0452722096568249	2.8762135922330097	6.247572815533981	0.4192390492462461	0.3068843884052658	1.4199402534298398	0.930533270242389	1.3963570929114475	0.294203492723015	0.0467857032007149	1.0	0.1169218221283287	0.2721697661507766	0.0002411780749914
+Major facilitator superfamily domain [IPR020846]	3	5	1.979992452315116	0.0477043767946561	1.8883495145631068	4.121359223300971	0.8776223597987594	0.2728824130413255	1.233496960525634	1.4580976091979958	1.2936014196902064	0.266909732326598	0.0465174752555924	1.0	1.0	0.1627514901813832	0.0547141411106198
+Immunoglobulin-like domain [IPR007110]	9	15	1.971910157393803	0.0486198635611159	4.480582524271845	12.427184466019416	0.4075261998509777	0.4433674298264088	2.6479725987944898	3.173316973839475	1.1756568118942026	0.3233613924696422	0.9557724520544868	1.0	1.0	0.9376661886227242	0.6438046979107276

interpro_domain/metrics.json

@@ -0,0 +1,7 @@
+{
+    "type_of_task": "ranksum",
+    "signature_size": 3236,
+    "annotations_size": 2625,
+    "title": "Average number of proteins per term",
+    "value": 2.1942857142857144
+}

interpro_domain/paths.json

@@ -0,0 +1 @@
+{"results_path": "results/proteins/hek293t_core/interpro_domain/fragment/C225/C225_val_log2fc"}

interpro_domain/result.tsv

@@ -0,0 +1,214 @@
+Term	es	nes	pval	sidak	fdr	geneset_size	leading_edge	leading_edge_size
+MENTAL domain [IPR019498]	0.965677179962894	2.5298584293447033	0.0114108557966035	0.9999999999999176	0.0404230721539597	2	Q14849	1
+MD-2-related lipid-recognition domain [IPR003172]	0.9465058750773035	2.445880134659786	0.0144499031724549	1.0	0.0474496074310049	2	P61916	1
+EF-hand domain [IPR002048]	0.48901464758125	2.3186327508305515	0.0204149577277121	1.0	0.0603830163257622	48	Q8IYU8,O43852,Q9BRK5,P41208,Q9Y680,Q02818,Q96AY3,Q6NUK1,P80303,Q14257,Q6KCM7,Q9NWM8,Q12841,O95202,Q8NF37,Q8IXI1,P0DP25,O75071	18
+P-type ATPase, haloacid dehalogenase domain [IPR044492]	0.8073893512477741	2.2944109617053363	0.0217669041066081	1.0	0.0626453820658386	8	P98194,Q9HD20,P05023,P35670,Q9NQ11,P16615	6
+Prenylcysteine lyase [IPR010795]	0.9078540507112056	2.27456088941575	0.0229322845401256	1.0	0.064741429347796	2	Q9UHG3	1
+FAD linked oxidase, N-terminal [IPR006094]	0.9069264069264162	2.270416832743097	0.0231823041301433	1.0	0.0651536920145891	2	Q15392	1
+FAD-binding domain, PCMH-type [IPR016166]	0.9069264069264162	2.270416832743097	0.0231823041301433	1.0	0.0651536920145891	2	Q15392	1
+Glycoside hydrolase family 2, catalytic domain [IPR006103]	0.8855905998763134	2.1746956811494864	0.0296529287590145	1.0	0.0773746898532935	2	P08236	1
+Fatty acid hydroxylase [IPR006694]	0.8834260977118299	2.164941777460309	0.0303921443041783	1.0	0.0786778883614084	2	Q15800	1
+Complex 1 LYR protein domain [IPR008011]	0.8812615955473091	2.1551800715906686	0.0311477457502302	1.0	0.0802383048030956	2	Q9NU23	1
+TRAM/LAG1/CLN8 homology domain [IPR006634]	0.8777697631291013	2.1449480970731587	0.0319569970670192	1.0	0.0817546551369887	5	P27544,Q96CP7,Q15629	3
+Diacylglycerol kinase, catalytic domain [IPR001206]	0.8667285095856649	2.089437976505868	0.036668315678185	1.0	0.0900414674043365	2	Q9NRA0	1
+Phospholipid/glycerol acyltransferase [IPR002123]	0.7342971147550887	2.0884339428702674	0.0367587083199867	1.0	0.0901717547983915	9	Q9NUQ2,Q8NF37,Q9HCL2	3
+ATPase family AAA domain-containing protein 3, N-terminal [IPR021911]	0.8654916512059359	2.0838271249674616	0.0371758950632363	1.0	0.0906939819154233	2	Q5T9A4	1
+LEM domain [IPR003887]	0.8158947120024022	2.041202345283069	0.0412307187048948	1.0	0.0960530214275464	6	Q86XL3,P42167	2
+GOLD domain [IPR009038]	0.8069171513386239	2.002116441218129	0.0452722096568249	1.0	0.1029805462297795	6	Q9BVK6,Q9Y3A6,Q9Y3B3,Q15363	4
+Marvel domain [IPR008253]	0.8457019171304969	1.9937280066992336	0.0461817869742957	1.0	0.1037659038847527	2	O43760	1
+Major facilitator superfamily domain [IPR020846]	0.838683905066283	1.9799924523151156	0.0477043767946561	1.0	0.106122024649129	5	Q9H2V7,Q7L0J3,P53985	3
+Immunoglobulin-like domain [IPR007110]	0.5908781127169717	1.971910157393803	0.0486198635611159	1.0	0.1077656262538091	15	P35613,P55899,Q9Y624,Q08722,P78310,Q92859,P01889,P10321,P04439	9
+GPAT/DHAPAT, acyltransferase domain [IPR041728]	0.8385899814471497	1.961203607815477	0.0498552761822743	1.0	0.1095147280154562	2	Q9HCL2	1
+Glycerol-3-phosphate acyltransferase-like, C-terminal domain [IPR045520]	0.8385899814471497	1.961203607815477	0.0498552761822743	1.0	0.1095147280154562	2	Q9HCL2	1
+Metaxin, glutathione S-transferase domain [IPR033468]	0.8259121830550611	1.9030448170030392	0.0570346975289997	1.0	0.1200610112378702	2	Q13505	1
+Mitochondrial outer membrane transport complex Sam37/metaxin, N-terminal domain [IPR019564]	0.8259121830550611	1.9030448170030392	0.0570346975289997	1.0	0.1200610112378702	2	Q13505	1
+ABC transporter type 1, transmembrane domain [IPR011527]	0.743502553566998	1.874340339295136	0.0608835308769166	1.0	0.1261399120378107	7	O75027,P33527,Q03518,P08183	4
+Syntaxin, N-terminal domain [IPR006011]	0.8734921125889272	1.8582467679557928	0.0631339793681284	1.0	0.1294252267450895	3	Q86Y82,O15400	2
+Band 7 domain [IPR001107]	0.7089345788649853	1.832210087834507	0.0669201265002135	1.0	0.13450637983389	8	O75955,Q14254,O75477,Q99623,P27105	5
+IMD/I-BAR domain [IPR013606]	0.8098330241187623	1.8289687573294953	0.0674042887288579	1.0	0.1351690281995814	2	Q9UQB8	1
+RBM1CTR [IPR012604]	0.8092145949288787	1.826113057803868	0.0678332337126663	1.0	0.135383894466487	2	Q96E39	1
+Acyl-CoA oxidase, C-terminal [IPR002655]	0.8085961657390209	1.8232568861538203	0.068264492885683	1.0	0.135573246380825	2	Q15067	1
+Peptidase M28 [IPR007484]	0.8625697944607409	1.8123473296133477	0.0699325457142829	1.0	0.1371995011210708	3	Q969V3	1
+N-acetylgalactosaminyltransferase [IPR045885]	0.8624134521575297	1.8116892711061343	0.0700342223330079	1.0	0.1372963656640372	3	Q8N4A0	1
+Cysteine-rich flanking region, C-terminal [IPR000483]	0.8048855905998742	1.806110057721998	0.0709011501100291	1.0	0.138273045348311	2	Q13641	1
+Follistatin-like, N-terminal [IPR003645]	0.8048855905998742	1.806110057721998	0.0709011501100291	1.0	0.138273045348311	2	Q12841	1
+Leucine-rich repeat N-terminal domain [IPR000372]	0.8048855905998742	1.806110057721998	0.0709011501100291	1.0	0.138273045348311	2	Q13641	1
+Reticulon [IPR003388]	0.8369776591587916	1.801015520428689	0.0717004337226541	1.0	0.139051769663448	4	O95197,Q9NQC3	2
+Sulfatase, N-terminal [IPR000917]	0.8567893597277928	1.7879977321905265	0.073776373708807	1.0	0.1419273637129348	3	P15289,P15586	2
+Alpha-L-fucosidase, C-terminal [IPR031919]	0.7993197278911754	1.7803590878602975	0.0750172127534578	1.0	0.1439475025422711	2	Q9BTY2	1
+Endoplasmic reticulum vesicle transporter, N-terminal [IPR039542]	0.7909709338281049	1.741666732037225	0.081566777016574	1.0	0.1527537232208566	2	Q9Y282	1
+Endoplasmic reticulum vesicle transporter, C-terminal [IPR012936]	0.7909709338281049	1.741666732037225	0.081566777016574	1.0	0.1527537232208566	2	Q9Y282	1
+Cytochrome b5-like heme/steroid binding domain [IPR001199]	0.7134516572331244	1.7354867586008804	0.0826546248607082	1.0	0.1538990876660096	7	O95864,O43169,Q9UMX5,O00264,O15173	5
+RBM3/CIRBP, RNA recognition motif [IPR034278]	0.7875695732838566	1.725881664578398	0.0843687039842804	1.0	0.155971502653263	2	Q14011	1
+Amine oxidase [IPR002937]	0.8096412683583736	1.685385045305049	0.091914307023452	1.0	0.1659093335303682	4	Q6QHF9	1
+Tim44-like domain [IPR007379]	0.777983920841061	1.6813342287335202	0.0926980129291425	1.0	0.1664379507106698	2	O43615	1
+Cation-transporting P-type ATPase, N-terminal [IPR004014]	0.7685167551220473	1.6772075812081773	0.0935018970830947	1.0	0.1674218650194069	5	P05023,P16615,P98194	3
+Cation-transporting P-type ATPase, C-terminal [IPR006068]	0.7685167551220473	1.6772075812081773	0.0935018970830947	1.0	0.1674218650194069	5	P05023,P16615,P98194	3
+Heterogeneous nuclear ribonucleoprotein Q acidic domain [IPR041337]	0.7668521954236212	1.6294972908187344	0.1032077879334001	1.0	0.1776527497214264	2	O60506	1
+Tubulin/FtsZ, 2-layer sandwich domain [IPR018316]	0.7536366450015478	1.6120040116125154	0.1069610667725955	1.0	0.1819222611520534	5	P04350,Q9BVA1,Q9BUF5,P07437	4
+Tubulin/FtsZ, GTPase domain [IPR003008]	0.7536366450015478	1.6120040116125154	0.1069610667725955	1.0	0.1819222611520534	5	P04350,Q9BVA1,Q9BUF5,P07437	4
+FAD dependent oxidoreductase [IPR006076]	0.7920236215895828	1.6103781274360816	0.1073153325968281	1.0	0.1823318757713099	4	Q96CU9	1
+Peptidase C1A, papain C-terminal [IPR000668]	0.7609771181199945	1.6020992800202702	0.1091336572020642	1.0	0.184110149940452	2	P53634	1
+Beta-hexosaminidase, eukaryotic type, N-terminal [IPR029019]	0.7600494743352146	1.5977710322239846	0.1100939437103805	1.0	0.1853730610902814	2	P06865	1
+Glycoside hydrolase family 20, catalytic domain [IPR015883]	0.7600494743352146	1.5977710322239846	0.1100939437103805	1.0	0.1853730610902814	2	P06865	1
+Iron sulphur domain-containing, mitoNEET, N-terminal [IPR019610]	0.7557204700062123	1.5775650506374044	0.114665566737057	1.0	0.1909880156629282	2	Q9NZ45	1
+Iron-binding zinc finger, CDGSH type [IPR018967]	0.7557204700062123	1.5775650506374044	0.114665566737057	1.0	0.1909880156629282	2	Q9NZ45	1
+Ricin B, lectin domain [IPR000772]	0.7431455893853322	1.565850365071786	0.1173836521119646	1.0	0.1947737590353395	5	Q8N4A0	1
+MIRO domain [IPR020860]	0.7510822510822479	1.5559031188017074	0.1197311316683722	1.0	0.1979182749555901	2	Q8IXI1	1
+EF hand associated, type-1 [IPR013566]	0.7510822510822479	1.5559031188017074	0.1197311316683722	1.0	0.1979182749555901	2	Q8IXI1	1
+EF hand associated, type-2 [IPR013567]	0.7510822510822479	1.5559031188017074	0.1197311316683722	1.0	0.1979182749555901	2	Q8IXI1	1
+Fzo/mitofusin HR2 domain [IPR006884]	0.748299319727888	1.5429002957757565	0.1228549690586056	1.0	0.2017630787129503	2	Q8IWA4	1
+Plasma membrane calcium transporting P-type ATPase, C-terminal [IPR022141]	0.7436611008039593	1.5212205984433893	0.1282044879965553	1.0	0.2092890429048245	2	P20020	1
+Ion transporter-like, CBS domain [IPR044751]	0.7402597402597371	1.505316364948347	0.1322427597843307	1.0	0.2136942472791694	2	Q8NE01	1
+CNNM, transmembrane domain [IPR002550]	0.7402597402597371	1.505316364948347	0.1322427597843307	1.0	0.2136942472791694	2	Q8NE01	1
+Immunoglobulin C1-set [IPR003597]	0.7648514851485246	1.4940597850734882	0.1351599938107686	1.0	0.2170141424935551	4	P55899,P04439,P01889	3
+MHC class I-like antigen recognition-like [IPR011161]	0.7648514851485246	1.4940597850734882	0.1351599938107686	1.0	0.2170141424935551	4	P55899,P04439,P01889	3
+EGF-like domain [IPR000742]	0.7263478012930819	1.491664441291385	0.1357871354015327	1.0	0.2174151761095188	5	O94813	1
+L27 domain, C-terminal [IPR014775]	0.7629950495049553	1.4860886564030602	0.1372556723459217	1.0	0.2191337828793643	4	Q9NZW5,Q14168,Q5T2T1	3
+L27 domain [IPR004172]	0.7629950495049553	1.4860886564030602	0.1372556723459217	1.0	0.2191337828793643	4	Q9NZW5,Q14168,Q5T2T1	3
+ERAP1-like C-terminal domain [IPR024571]	0.7614215446958377	1.4793302483955473	0.1390520722853505	1.0	0.2210852148691975	4	Q9UIQ6	1
+Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase, N-terminal [IPR018955]	0.7325293753865334	1.4691561260110857	0.1417904473329443	1.0	0.2246199533938877	2	Q15118	1
+Histidine kinase domain [IPR005467]	0.7325293753865334	1.4691561260110857	0.1417904473329443	1.0	0.2246199533938877	2	Q15118	1
+EH domain-containing protein, N-terminal [IPR031692]	0.7312925170067994	1.46336906824581	0.1433664178038971	1.0	0.2264361292029061	2	Q9H4M9	1
+Domain of unknown function DUF5600 [IPR040990]	0.7312925170067994	1.46336906824581	0.1433664178038971	1.0	0.2264361292029061	2	Q9H4M9	1
+Glycosyltransferase 2-like [IPR001173]	0.7191496783735899	1.4597762748575012	0.1443515710440617	1.0	0.2276038661108864	5	Q8N4A0,Q10472	2
+Band 3 cytoplasmic domain [IPR013769]	0.7282003710575242	1.4489002208447188	0.1473654494813168	1.0	0.2305329588131445	2	Q9Y6M7	1
+Bicarbonate transporter, C-terminal [IPR011531]	0.7282003710575242	1.4489002208447188	0.1473654494813168	1.0	0.2305329588131445	2	Q9Y6M7	1
+EGF-like calcium-binding domain [IPR001881]	0.7486555181719128	1.424432353452374	0.1543213542024784	1.0	0.2385709981045381	4	O94813	1
+OTU domain [IPR003323]	0.7192331478045757	1.4069356273524063	0.1594464778897493	1.0	0.2439914511517901	2	Q96FW1	1
+AMP-binding enzyme, C-terminal domain [IPR025110]	0.7051925484281292	1.3977982863098406	0.1621736491347447	1.0	0.2465001904914331	5	Q9UKU0	1
+MHC class I alpha chain, alpha1 alpha2 domains [IPR001039]	0.764614908753469	1.3955272722447205	0.1628568966086228	1.0	0.2466946814283583	3	P04439,P01889	2
+MHC class I, alpha chain, C-terminal [IPR010579]	0.764614908753469	1.3955272722447205	0.1628568966086228	1.0	0.2466946814283583	3	P04439,P01889	2
+Target SNARE coiled-coil homology domain [IPR000727]	0.6188564783993868	1.3887674543066792	0.16490347485471	1.0	0.2490630733565096	8	Q86Y82,Q5SQN1,Q9UNK0,O15400,Q13277,O60499	6
+Dynamin, N-terminal [IPR045063]	0.6166862464768054	1.377877038087868	0.1682412554712131	1.0	0.2529400318510507	8	O60313,O95140,Q8IWA4,Q9H4M9	4
+Dynamin-type guanine nucleotide-binding (G) domain [IPR030381]	0.6166862464768054	1.377877038087868	0.1682412554712131	1.0	0.2529400318510507	8	O60313,O95140,Q8IWA4,Q9H4M9	4
+Exocyst complex component EXOC2/Sec5, N-terminal domain [IPR039481]	0.7118119975262835	1.372209041742588	0.1699983714839685	1.0	0.2548519275530654	2	Q9UID3	1
+Choline/carnitine acyltransferase domain [IPR039551]	0.757522990113928	1.365129211156401	0.1722124423927074	1.0	0.2578765894357426	3	P23786	1
+Immunoglobulin V-set domain [IPR013106]	0.7318522386792154	1.352026595686086	0.1763668074466706	1.0	0.2623004978785395	4	P78310	1
+Homeobox domain [IPR001356]	0.7503146831741869	1.334227044662771	0.1821294587617652	1.0	0.2679875724493463	3	Q96G23	1
+UBX domain [IPR001012]	0.7193052577399277	1.297889801373352	0.1943252050981665	1.0	0.2808940877657969	4	Q9UNZ2	1
+Sam68, tyrosine-rich domain [IPR032335]	0.6954236239950486	1.2955786696928686	0.1951206817911328	1.0	0.2812695165852409	2	O75525	1
+KHDRBS, Qua1 domain [IPR032571]	0.6954236239950486	1.2955786696928686	0.1951206817911328	1.0	0.2812695165852409	2	O75525	1
+NOPS [IPR012975]	0.739870089699971	1.2894545111749447	0.1972401209144378	1.0	0.2835461760133622	3	Q8WXF1,P23246	2
+Longin domain [IPR010908]	0.7396803258970894	1.2886412049581828	0.197522851419333	1.0	0.2836290769351155	3	P51809	1
+v-SNARE, coiled-coil homology domain [IPR042855]	0.7396803258970894	1.2886412049581828	0.197522851419333	1.0	0.2836290769351155	3	P51809	1
+Thioredoxin-like fold [IPR012336]	0.693877551020404	1.2883563789044836	0.1976219358911719	1.0	0.2836290769351155	2	Q6DKJ4	1
+4Fe-4S ferredoxin-type, iron-sulphur binding domain [IPR017896]	0.7159639426005	1.2834672412115906	0.1993284293456083	1.0	0.2856097854979377	4	Q16134	1
+RNA recognition motif domain, eukaryote [IPR003954]	0.4978624730675361	1.2812328113192537	0.2001119045227362	1.0	0.2864197106718552	14	Q9UHX1,Q96E39,P38159,Q14011,Q14498	5
+Alcohol dehydrogenase, N-terminal [IPR013154]	0.6723048011975219	1.2511803552919665	0.2108686837405131	1.0	0.2952161572367184	5	Q8WWV3,Q8N4Q0	2
+Patatin-like phospholipase domain [IPR002641]	0.6858379715522531	1.2508288224166852	0.2109969368391939	1.0	0.2952382511742453	2	Q8IY17	1
+Tim10-like [IPR004217]	0.7207846559203261	1.2077179527688728	0.2271557700903785	1.0	0.3112128896071209	3	Q9Y5J7	1
+Polyketide synthase, enoylreductase domain [IPR020843]	0.6297218907128822	1.2013405510127686	0.2296191265101161	1.0	0.3136057268933688	6	Q8WWV3,Q8N4Q0	2
+BRO1 domain [IPR004328]	0.6617192331478084	1.1386623400150009	0.2548440160806771	1.0	0.3362762391916236	2	Q8WUM4	1
+Vacuolar protein sorting-associated protein 13, C-terminal [IPR031645]	0.699233452487561	1.1157003915701884	0.2645504029117336	1.0	0.3449800336032293	3	Q96RL7	1
+Vacuolar protein sorting-associated protein 13, SHR-binding domain [IPR009543]	0.699233452487561	1.1157003915701884	0.2645504029117336	1.0	0.3449800336032293	3	Q96RL7	1
+Vacuolar protein sorting-associated protein 13-like, N-terminal domain [IPR026854]	0.699233452487561	1.1157003915701884	0.2645504029117336	1.0	0.3449800336032293	3	Q96RL7	1
+VPS13, repeated coiled region [IPR031642]	0.699233452487561	1.1157003915701884	0.2645504029117336	1.0	0.3449800336032293	3	Q96RL7	1
+Vacuolar protein sorting-associated protein 13, second N-terminal domain [IPR031646]	0.699233452487561	1.1157003915701884	0.2645504029117336	1.0	0.3449800336032293	3	Q96RL7	1
+Acyltransferase, C-terminal domain [IPR032098]	0.6940954478433428	1.0938316328543451	0.2740288277469327	1.0	0.3526106239390678	3	Q9NUQ2	1
+Zinc finger C2H2 AKAP95-type [IPR034736]	0.6903804515929375	1.0780406352892562	0.2810156222608424	1.0	0.3586125466381679	3	O43823,Q9ULX6	2
+CYRIA/CYRIB, Rac1 binding domain [IPR009828]	0.6875966594494302	1.0662204092434704	0.2863240182969497	1.0	0.3637950377683897	3	Q7L576,Q96F07	2
+Peptidase M41 [IPR000642]	0.6413110698825165	1.0445098505628083	0.2962495641277216	1.0	0.3710186573641552	2	Q9Y4W6	1
+FAD/NAD(P)-binding domain [IPR023753]	0.6130196787699981	0.9866324247244888	0.3238228685700721	1.0	0.3921394680107236	5	P09622	1
+Intermediate filament, rod domain [IPR039008]	0.5303593556381551	0.9403318107973988	0.3470473873310413	1.0	0.4123276470960898	8	P48681,Q03252,P20700,P07196,P02545,Q16352,P08670	7
+CD80-like, immunoglobulin C2-set [IPR013162]	0.6079158936301737	0.8928935318836211	0.3719141912502073	1.0	0.433514543530992	2	Q13740	1
+AMP-dependent synthetase/ligase [IPR000873]	0.5086999396674591	0.830457769810156	0.4062800148289949	1.0	0.4681672690632623	8	Q9UKU0	1
+Guanylate kinase-like domain [IPR008144]	0.5065543297424628	0.8196088267430961	0.4124391401356564	1.0	0.4742237156618914	8	Q9NZW5,Q00013,Q14168,Q5T2T1	4
+Guanylate kinase/L-type calcium channel beta subunit [IPR008145]	0.5065543297424628	0.8196088267430961	0.4124391401356564	1.0	0.4742237156618914	8	Q9NZW5,Q00013,Q14168,Q5T2T1	4
+Ribosomal L28e/Mak16 [IPR029004]	0.5871985157699461	0.8010585919796931	0.4230977266059166	1.0	0.4852603376655322	2	Q9BXY0	1
+Complement Clr-like EGF domain [IPR026823]	0.5868893011750096	0.7997041915127405	0.423882203884907	1.0	0.485467183768709	2	Q07954	1
+Cyclic nucleotide-binding domain [IPR000595]	0.5696514018365827	0.795632511293955	0.4262456641072267	1.0	0.4875358903187234	5	Q9Y4G8,Q8IY17	2
+SWIB domain [IPR019835]	0.5844155844155785	0.7888879176076503	0.4301775180922451	1.0	0.4911770269648297	2	Q96GM5	1
+CUB domain [IPR000859]	0.5810142238713609	0.7740718489474855	0.4388883038040436	1.0	0.5002526259164631	2	O14786	1
+Protein kinase, C-terminal [IPR017892]	0.5303399861554922	0.7435667537277071	0.4571386228120893	1.0	0.5181299157520441	6	Q15418	1
+FKBP-type peptidyl-prolyl cis-trans isomerase domain [IPR001179]	0.4333858240780094	0.7157763597937602	0.4741294518393006	1.0	0.5341587172009289	12	Q9Y680	1
+Ribosomal protein S10 domain [IPR027486]	0.5624613481756278	0.6945183426447524	0.4873572017506637	1.0	0.5469485483520703	2	P60866	1
+EH domain [IPR000261]	0.5708370958321223	0.6690234432388406	0.5034805236097302	1.0	0.5628775019061081	4	Q9H4M9	1
+Brix domain [IPR007109]	0.5697255855694792	0.6645495863329998	0.5063386232286917	1.0	0.565591015308645	4	Q96G21,Q9NQ55	2
+ABC transporter-like, ATP-binding domain [IPR003439]	0.4349027162527662	0.6611164783259114	0.5085376184381472	1.0	0.5678057202892965	11	O75027,P33527,Q03518,P08183	4
+CBS domain [IPR000644]	0.4884929838746861	0.659138096768226	0.5098070937220383	1.0	0.5684571466071376	7	P51798	1
+3'-5' exonuclease domain [IPR002562]	0.5534941249226902	0.6569233058139989	0.5112302318054998	1.0	0.5693590829399405	2	Q9NVH0	1
+HRDC domain [IPR002121]	0.5534941249226899	0.6569233058139973	0.5112302318055009	1.0	0.5693590829399405	2	P54132	1
+NLE [IPR012972]	0.5473098330241122	0.6313604939345776	0.5278048410027325	1.0	0.5848407377088108	2	Q9GZL7	1
+Flavoprotein pyridine nucleotide cytochrome reductase-like, FAD-binding domain [IPR008333]	0.5463821892393257	0.6275531535151675	0.5302967055114411	1.0	0.5871062218336284	2	P00387	1
+S100/CaBP-9k-type, calcium binding, subdomain [IPR013787]	0.5781008351376465	0.6186031693792263	0.536177813441459	1.0	0.5931170502671006	3	Q99584,P60903	2
+Fibronectin type II domain [IPR000562]	0.5693959485929386	0.5854219156138765	0.5582640562820371	1.0	0.6123874415964677	3	Q9UBV2	1
+Acyl-CoA oxidase/dehydrogenase, central domain [IPR006091]	0.4299185310138161	0.5797191651510755	0.562104016976456	1.0	0.6155707319829774	10	Q15067,O15254,P11310,Q709F0,P45954	5
+Phosphoinositide 3-kinase, accessory (PIK) domain [IPR001263]	0.5337043908472411	0.5762738938433171	0.5644300656491767	1.0	0.6176027187699412	2	P42356	1
+SKP1 component, POZ domain [IPR016073]	0.5309214594928813	0.5652154358859501	0.5719272388034575	1.0	0.6250245636382499	2	Q15369	1
+Zinc finger, CHHC-type [IPR012996]	0.5552138337541569	0.5325253136166206	0.5943622144014207	1.0	0.6465813563214792	3	P31943	1
+Immunoglobulin subtype 2 [IPR003598]	0.4207080404587636	0.5293439485444336	0.5965668735723546	1.0	0.6484422538829941	10	P35613,P78310,Q9Y624,Q92859	4
+Immunoglobulin subtype [IPR003599]	0.4207080404587636	0.5293439485444336	0.5965668735723546	1.0	0.6484422538829941	10	P35613,P78310,Q9Y624,Q92859	4
+Intermediate filament head, DNA-binding domain [IPR006821]	0.5297029702970565	0.508345400699569	0.6112111358846826	1.0	0.6627134372975183	4	P07196,Q16352,P08670	3
+Ribosomal protein S4/S9, N-terminal [IPR001912]	0.5132962275819348	0.4970031802288919	0.6191868086805745	1.0	0.6708070048644277	2	Q9NV31	1
+Aminopeptidase N-like , N-terminal domain [IPR045357]	0.4721211609987373	0.4880827570915808	0.625491223988994	1.0	0.6759631383166362	6	Q9UIQ6	1
+Peptidase M1, membrane alanine aminopeptidase [IPR014782]	0.4721211609987373	0.4880827570915808	0.625491223988994	1.0	0.6759631383166362	6	Q9UIQ6	1
+Lamin tail domain [IPR001322]	0.5422208475100564	0.4854700767469024	0.6273429338041348	1.0	0.6776852679982938	3	Q03252,P02545	2
+Bms1/Tsr1-type G domain [IPR030387]	0.5074211502782859	0.4750190886027011	0.6347733676610106	1.0	0.6843039384435946	2	Q14692	1
+Ribosome biogenesis protein BMS1/TSR1, C-terminal [IPR007034]	0.5074211502782859	0.4750190886027011	0.6347733676610106	1.0	0.6843039384435946	2	Q14692	1
+AARP2CN [IPR012948]	0.5074211502782859	0.4750190886027011	0.6347733676610106	1.0	0.6843039384435946	2	Q14692	1
+Sulphate adenylyltransferase catalytic domain [IPR024951]	0.5052566481137837	0.4670212246593354	0.6404846928472607	1.0	0.6887637520377138	2	O43252	1
+ATP-sulfurylase PUA-like domain [IPR025980]	0.5052566481137837	0.4670212246593354	0.6404846928472607	1.0	0.6887637520377138	2	O43252	1
+Sulphate adenylyltransferase [IPR002650]	0.5052566481137837	0.4670212246593354	0.6404846928472607	1.0	0.6887637520377138	2	O43252	1
+Chromo shadow domain [IPR008251]	0.5258274048871057	0.4282617826057017	0.6684605398224042	1.0	0.7154358870654359	3	P83916,Q13185	2
+Chromo domain subgroup [IPR017984]	0.5258274048871057	0.4282617826057017	0.6684605398224042	1.0	0.7154358870654359	3	P83916,Q13185	2
+Far upstream element-binding protein, C-terminal [IPR015096]	0.4888682745825552	0.4083502194720042	0.6830165748790615	1.0	0.726074007725918	2	Q92945	1
+RNA-binding S4 domain [IPR002942]	0.5134549953603499	0.3868599707597244	0.6988598768872087	1.0	0.7409156610779172	3	P62701,Q9NV31	2
+Putative RNA methylase domain [IPR000241]	0.4792826221397572	0.3756791613116909	0.7071554318220095	1.0	0.7491053303199253	2	Q9BV44	1
+Heat shock chaperonin-binding [IPR006636]	0.4657477115104967	0.3712188795644872	0.7104745123151195	1.0	0.7512259569723144	5	Q9UHD9,P54725	2
+Ribosomal protein/NADH dehydrogenase domain [IPR007741]	0.471861471861464	0.3512804471432786	0.7253779623467791	1.0	0.7647056831969057	2	P82663	1
+I-kappa-kinase-beta NEMO binding domain [IPR022007]	0.4706246134817511	0.3472926547969456	0.728371468417546	1.0	0.7669374667453102	2	O15111	1
+IKBKB, scaffold dimerization domain [IPR041185]	0.4706246134817511	0.3472926547969456	0.728371468417546	1.0	0.7669374667453102	2	O15111	1
+SARAH domain [IPR011524]	0.469078540507104	0.3423401138388329	0.7320949507719667	1.0	0.7699315888527295	2	Q13188	1
+Mst1 SARAH domain [IPR024205]	0.469078540507104	0.3423401138388329	0.7320949507719667	1.0	0.7699315888527295	2	Q13188	1
+Armadillo repeat-containing domain [IPR006911]	0.4641311069882419	0.3267356868395178	0.7438678061489215	1.0	0.7810611964563675	2	Q96D09	1
+Dynamin, GTPase domain [IPR001401]	0.4727722772277467	0.3088028719833694	0.7574714843247918	1.0	0.7943917883949575	4	O60313,Q9UQ16,P50570	3
+Cyclin-like [IPR013763]	0.4560915275200934	0.3021899565168219	0.7625072601031346	1.0	0.7980787710409603	2	P20248	1
+Cyclin, C-terminal domain [IPR004367]	0.4560915275200934	0.3021899565168219	0.7625072601031346	1.0	0.7980787710409603	2	P20248	1
+Cyclin, N-terminal [IPR006671]	0.4560915275200934	0.3021899565168219	0.7625072601031346	1.0	0.7980787710409603	2	P20248	1
+ZU5 domain [IPR000906]	0.4533085961657307	0.2939332751081248	0.7688088907709809	1.0	0.8043536621258768	2	Q07157	1
+Legume-like lectin [IPR005052]	0.476549616220044	0.2738485117907704	0.7842010410581546	1.0	0.8188256693626316	3	Q9H0V9	1
+Serine/arginine-rich splicing factor SRSF4-like, RNA recognition motif 1 [IPR035585]	0.4449598021026509	0.2699240327624501	0.7872186977227758	1.0	0.8211015787238087	2	Q13243	1
+Proteasome activator PA28, N-terminal domain [IPR003185]	0.4751005258274094	0.2697637334507579	0.7873420252391681	1.0	0.8211015787238087	3	P61289,Q06323	2
+Proteasome activator PA28, C-terminal domain [IPR003186]	0.4751005258274094	0.2697637334507579	0.7873420252391681	1.0	0.8211015787238087	3	P61289,Q06323	2
+GTPase effector domain [IPR020850]	0.4726260439220582	0.2628543579480477	0.7926628366001833	1.0	0.825362929819707	3	Q9UQ16,P50570	2
+Dynamin GTPase effector [IPR003130]	0.4726260439220582	0.2628543579480477	0.7926628366001833	1.0	0.825362929819707	3	Q9UQ16,P50570	2
+Dynamin stalk domain [IPR000375]	0.4726260439220582	0.2628543579480477	0.7926628366001833	1.0	0.825362929819707	3	Q9UQ16,P50570	2
+KASH domain [IPR012315]	0.4353741496598565	0.2438021660636602	0.8073840426689893	1.0	0.8377008347850186	2	Q8NF91	1
+PAZ domain [IPR003100]	0.4325912183054982	0.2365142448139117	0.8130336550322643	1.0	0.8425634995892988	2	Q9UL18	1
+FAST kinase-like protein, subdomain 2 [IPR013579]	0.4621094958243154	0.2344349418642154	0.8146473346568299	1.0	0.8432370873320894	3	Q7L8L6,Q969Z0	2
+RAP domain [IPR013584]	0.4621094958243154	0.2344349418642154	0.8146473346568299	1.0	0.8432370873320894	3	Q7L8L6,Q969Z0	2
+FAST kinase leucine-rich [IPR010622]	0.4621094958243154	0.2344349418642154	0.8146473346568299	1.0	0.8432370873320894	3	Q7L8L6,Q969Z0	2
+Metastasis-associated protein MTA1, R1 domain [IPR035170]	0.4537581193937555	0.2129873199564346	0.8313368529864864	1.0	0.8591571807439082	3	Q9BTC8,O94776	2
+Tudor domain [IPR002999]	0.3724509869192295	0.190970611060476	0.8485486183589463	1.0	0.8750484459667164	8	Q14739	1
+Nucleotidyl transferase domain [IPR005835]	0.4131106988249777	0.1893272947040671	0.8498363040835988	1.0	0.8750484459667164	2	Q9NR50	1
+Extended synaptotagmin, C2B domain [IPR037749]	0.4128014842300481	0.1886330679495578	0.8503804135851785	1.0	0.8750484459667164	2	A0FGR8	1
+Synaptotagmin-like mitochondrial-lipid-binding domain [IPR031468]	0.4128014842300481	0.1886330679495578	0.8503804135851785	1.0	0.8750484459667164	2	A0FGR8	1
+Extended synaptotagmin, C-terminal C2 domain [IPR037752]	0.4128014842300481	0.1886330679495578	0.8503804135851785	1.0	0.8750484459667164	2	A0FGR8	1
+Extended synaptotagmin, C2A domain [IPR037733]	0.4128014842300481	0.1886330679495578	0.8503804135851785	1.0	0.8750484459667164	2	A0FGR8	1
+Synaptotagmin, SMP domain [IPR039010]	0.4128014842300481	0.1886330679495578	0.8503804135851785	1.0	0.8750484459667164	2	A0FGR8	1
+Sterile alpha motif domain [IPR001660]	0.3752022550074251	0.1750822573923462	0.8610149994797678	1.0	0.8852974436484099	7	Q15375,Q9Y3Z3	2
+Cadherin-like [IPR002126]	0.4287039901020771	0.1548723590398779	0.8769219449846406	1.0	0.9012999630323734	3	Q14126,Q14574	2
+Phosphatidylinositol 3-/4-kinase, catalytic domain [IPR000403]	0.3657479095695189	0.1416394971881169	0.8873647671836744	1.0	0.9106069248855142	7	P78527,Q9UBF8,P42356,Q13315,P42345,Q9BTU6	6
+Isopropylmalate dehydrogenase-like domain [IPR024084]	0.4074876237623858	0.1287276705525501	0.8975731396333901	1.0	0.9189272587900348	4	O75874,O43837,P48735	3
+NIPSNAP [IPR012577]	0.4095267553356052	0.1169216150410575	0.906922169307078	1.0	0.9281367229750798	3	Q9UFN0,Q9BPW8	2
+Zinc finger, A20-type [IPR002653]	0.3661100803957874	0.1035734108278176	0.917507889238224	1.0	0.9371432720818436	2	Q6GQQ9	1
+Zinc finger, RanBP2-type [IPR001876]	0.3454726609582922	0.0893089006118182	0.9288364206727936	1.0	0.9477258877445028	8	Q92804	1
+Rhodanese-like domain [IPR001763]	0.3888370513679662	0.0891636049136169	0.928951889206326	1.0	0.9477258877445028	4	P40818	1
+Circularly permuted (CP)-type guanine nucleotide-binding (G) domain [IPR030378]	0.3609558520819272	0.088313678979281	0.9296273671829656	1.0	0.9480465574418356	6	Q9BT17	1
+Small-subunit processome, Utp12 [IPR007148]	0.3807609031858993	0.0707136784087477	0.9436256342953316	1.0	0.960517734621064	3	Q9UNX4,Q15061	2
+Citron homology (CNH) domain [IPR001180]	0.3382807668521878	0.0706380772892245	0.9436858047953234	1.0	0.960517734621064	2	O95819	1
+Thioredoxin domain [IPR013766]	0.2842703800773026	0.0584011669324749	0.953429085282976	1.0	0.969102725346204	25	Q96JJ7,O43819,Q9H3N1,Q6ZRP7,Q9H1E5,Q9Y2G8,Q9Y320	7
+AGC-kinase, C-terminal [IPR000961]	0.3227018825764627	0.0501420411391162	0.9600091978707148	1.0	0.9744872948223614	10	Q15418	1
+GNAT domain [IPR000182]	0.3559269575982722	0.0481601511941647	0.9615886080546818	1.0	0.9747623254258662	5	Q9H9T3,Q9H0A0,P41227,Q86UY6	4
+PIK-related kinase, FAT [IPR003151]	0.3654084158415867	0.0474722678615012	0.9621368324489216	1.0	0.9747623254258662	4	Q13315,P78527,P42345	3
+FATC domain [IPR003152]	0.3654084158415867	0.0474722678615012	0.9621368324489216	1.0	0.9747623254258662	4	Q13315,P78527,P42345	3
+PIK-related kinase [IPR014009]	0.3654084158415867	0.0474722678615012	0.9621368324489216	1.0	0.9747623254258662	4	Q13315,P78527,P42345	3
+Peptidase M16, N-terminal [IPR011765]	0.3344772555843244	0.0425070063848877	0.9660945265127632	1.0	0.9768867997288148	7	Q5JRX3,P14735,Q10713	3
+Peptidase M16, C-terminal [IPR007863]	0.3344772555843244	0.0425070063848877	0.9660945265127632	1.0	0.9768867997288148	7	Q5JRX3,P14735,Q10713	3
+Zinc finger, GATA-type [IPR000679]	0.3457134014237188	0.0281406926591413	0.9775499388646728	1.0	0.9852799313152522	5	Q13330,Q9BTC8,Q8WXI9,O94776	4
+Acyl-CoA dehydrogenase/oxidase C-terminal [IPR009075]	0.3270331846137284	0.0279352436312888	0.977713799051568	1.0	0.9852799313152522	8	Q709F0,P11310,P45954	3
+Acyl-CoA dehydrogenase/oxidase, N-terminal [IPR013786]	0.3270331846137284	0.0279352436312888	0.977713799051568	1.0	0.9852799313152522	8	Q709F0,P11310,P45954	3
+Ubiquitin-associated domain [IPR015940]	0.3007411242019873	0.0154014348667248	0.987711918704957	1.0	0.9941502249235094	13	Q9UHD9,Q9UPU5,P54725,Q5THJ4	4
+Matrin/U1-C, C2H2-type zinc finger [IPR000690]	0.3275541795665612	0.0063175911153998	0.994959325118113	1.0	1.0	6	Q12874,P43243,P09234,Q15428,Q9ULV3	5
+Endonuclease/exonuclease/phosphatase [IPR005135]	0.3326113861386134	0.0037133358348256	0.9970371934772736	1.0	1.0	4	Q9UNK9,Q01968,P27695	3