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interpro_active_site/advanced/idx2term.json

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+{}

interpro_active_site/basic/idx2term.json

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+{}

interpro_active_site/consensus.joblib

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+version https://git-lfs.github.com/spec/v1
+oid sha256:25e1a3f5d603ab037302f67540cb578fa4e0f3d22df4f248d027f85d91ac99ca
+size 88550

interpro_active_site/df_merge.tsv

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+term	overlap	setsize	score	pval	overlap_mean	setsize_mean	score_mean	pval_mean	overlap_std	setsize_std	score_std	pval_std	pval_hit	pval_50	pval_100	pval_250	pval_500

interpro_active_site/metrics.json

@@ -0,0 +1,7 @@
+{
+    "type_of_task": "ranksum",
+    "signature_size": 3236,
+    "annotations_size": 53,
+    "title": "Average number of proteins per term",
+    "value": 2.641509433962264
+}

interpro_active_site/paths.json

@@ -0,0 +1 @@
+{"results_path": "results/proteins/hek293t_core/interpro_active_site/fragment/C228/C228_val_log2fc"}

interpro_active_site/result.tsv

@@ -0,0 +1,3 @@
+Term	es	nes	pval	sidak	fdr	geneset_size	leading_edge	leading_edge_size
+Histidine acid phosphatase active site [IPR033379]	0.8540507111935876	3.5360571496836535	0.0004061468208469	0.0213000346972089	0.0009784446138585	2	Q9NPH0	1
+Serine carboxypeptidase, serine active site [IPR018202]	0.8094648932879598	3.0350643172639833	0.0024048439686619	0.1198036164336213	0.0039830228230963	3	Q9HB40,P10619	2

interpro_active_site/selections.json

@@ -0,0 +1 @@
+{"all_annotations": ["ATP synthase, F0 complex, subunit A, active site [IPR023011]", "ATP-citrate lyase/succinyl-CoA ligase, active site [IPR017440]", "ATP:guanido phosphotransferase active site [IPR022415]", "ATPase, alpha/beta subunit, nucleotide-binding domain, active site [IPR020003]", "Adenylosuccinate synthase,  active site [IPR033128]", "Beta-ketoacyl synthase, active site [IPR018201]", "Citrate synthase active site [IPR019810]", "ClpP, Ser active site [IPR018215]", "ClpP, histidine active site [IPR033135]", "Cysteine peptidase, asparagine active site [IPR025661]", "Cysteine peptidase, cysteine active site [IPR000169]", "Cysteine peptidase, histidine active site [IPR025660]", "DNA methylase, C-5 cytosine-specific, active site [IPR018117]", "DNA topoisomerase I, active site [IPR018521]", "Ferrochelatase, active site [IPR019772]", "Glucose-6-phosphate dehydrogenase, active site [IPR019796]", "Glyceraldehyde 3-phosphate dehydrogenase, active site [IPR020830]", "Glycoside hydrolase, family 2, active site [IPR023232]", "Glycosyl hydrolases family 31, active site [IPR030458]", "Histidine acid phosphatase active site [IPR033379]", "Hydroxymethylglutaryl-CoA lyase, active site [IPR000138]", "Hydroxymethylglutaryl-coenzyme A synthase, active site [IPR000590]", "L-lactate dehydrogenase, active site [IPR018177]", "Malate dehydrogenase, active site [IPR001252]", "Nucleoside diphosphate kinase, active site [IPR023005]", "Orotidine 5'-phosphate decarboxylase, active site [IPR018089]", "Peptidase S16, active site [IPR008268]", "Peptidase S26A, signal peptidase I, serine active site [IPR019756]", "Peptidase S8, subtilisin, His-active site [IPR022398]", "Peptidase S8, subtilisin, Ser-active site [IPR023828]", "Peptidase S9, serine active site [IPR002471]", "Peptidase family C14A, His active site [IPR016129]", "Peptidase family C14A, cysteine active site [IPR033139]", "Phosphoglycerate/bisphosphoglycerate mutase, active site [IPR001345]", "Phosphoribosylglycinamide formyltransferase, active site [IPR001555]", "Protein-tyrosine phosphatase, active site [IPR016130]", "Pyridine nucleotide-disulphide oxidoreductase, class I, active site [IPR012999]", "Pyruvate kinase, active site [IPR018209]", "Ribonuclease T2, His active site 1 [IPR018188]", "Ribonuclease T2, His active site 2 [IPR033130]", "Ribonucleotide reductase small subunit, acitve site [IPR030475]", "Serine carboxypeptidase, serine active site [IPR018202]", "Serine carboxypeptidases, histidine active site [IPR033124]", "Serine/threonine-protein kinase, active site [IPR008271]", "Thermonuclease active site [IPR002071]", "Thiolase, active site [IPR020610]", "Thiolase, acyl-enzyme intermediate active site [IPR020615]", "Thymidylate synthase, active site [IPR020940]", "Transaldolase, active site [IPR018225]", "Triosephosphate isomerase, active site [IPR020861]", "Tyrosine-protein kinase, active site [IPR008266]", "Ubiquitin-activating enzyme E1, Cys active site [IPR033127]", "Ubiquitin-conjugating enzyme, active site [IPR023313]"], "available_proteins": ["ACAA1", "ACAA2", "ACAT1", "ACAT2", "ACLY", "ACP2", "ACP6", "ADSS", "AKT2", "APEH", "ATP5A1", "ATP5B", "ATP6", "ATP6V1A", "ATP6V1B2", "AURKB", "BLMH", "CAMK1", "CAMK2G", "CAPN1", "CASP7", "CDK1", "CDK11B", "CDK12", "CDK2", "CDK4", "CDK5", "CDK6", "CDK9", "CHUK", "CIT", "CKB", "CKMT1A*", "CLPP", "CPVL", "CS", "CSK", "CSNK1A1", "CSNK2A2", "CTSA", "CTSC", "CTSZ", "DLD", "DNMT1", "DUSP3", "EIF2AK2", "EPHA7", "FASN", "FECH", "G6PD", "GAA", "GAK", "GANAB", "GAPDH", "GART", "GSK3A", "GSK3B", "GSR", "GUSB", "HADHB", "HMGCL", "HMGCS1", "IGF1R", "IKBKB", "LDHA", "LDHB", "LONP1", "LYN", "MAP2K1", "MAP2K2", "MAP4K4", "MAPK1", "MAPK3", "MASTL", "MDH1", "MDH2", "NEK9", "NME1", "PAK2", "PBK", "PGAM1", "PIK3R4", "PKM", "PKMYT1", "PKN1", "PKN2", "PLK1", "PREP", "PRKACA", "PRKCA", "PRPF4B", "PTK2", "PTK7", "PTPMT1", "PTPN1", "PTPN11", "PTPRF", "PTPRS", "RNASET2", "ROCK2", "RPS6KA1", "RPS6KA3", "RRM2", "SCP2", "SCPEP1", "SEC11A", "SLK", "SND1", "SRPK1", "SUCLG1", "TALDO1", "TIGAR", "TOP1", "TPI1", "TPP2", "TTK", "TXNRD1", "TYMS", "UBA1", "UBA2", "UBA3", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UMPS", "VRK1", "VRK2", "WNK1"], "leading_proteins": ["ACP6", "CTSA", "SCPEP1"]}

interpro_binding_site/advanced/idx2term.json

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+{"0": "EF-Hand 1, calcium-binding site [IPR018247]"}

interpro_binding_site/basic/idx2term.json

@@ -0,0 +1 @@
+{"0": "EF-Hand 1, calcium-binding site [IPR018247]"}

interpro_binding_site/consensus.joblib

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+version https://git-lfs.github.com/spec/v1
+oid sha256:46dea9f5ec016883b0b531c559d70f4945c1b68683a7828b8c016b8178f73206
+size 82664

interpro_binding_site/df_merge.tsv

@@ -0,0 +1,2 @@
+term	overlap	setsize	score	pval	overlap_mean	setsize_mean	score_mean	pval_mean	overlap_std	setsize_std	score_std	pval_std	pval_hit	pval_50	pval_100	pval_250	pval_500
+EF-Hand 1, calcium-binding site [IPR018247]	13	39	2.311894939838008	0.0207834736545162	10.019417475728156	36.70631067961165	0.9532938980945532	0.3894555773109194	3.76037227687173	3.057484685571999	1.1082350706804749	0.3408841825650379	5.002086641327136e-05	0.0531691841805127	0.039273671719942	0.041225662206046	2.177645337595772e-05

interpro_binding_site/metrics.json

@@ -0,0 +1,7 @@
+{
+    "type_of_task": "ranksum",
+    "signature_size": 3236,
+    "annotations_size": 32,
+    "title": "Average number of proteins per term",
+    "value": 4.65625
+}

interpro_binding_site/paths.json

@@ -0,0 +1 @@
+{"results_path": "results/proteins/hek293t_core/interpro_binding_site/fragment/C228/C228_val_log2fc"}

interpro_binding_site/result.tsv

@@ -0,0 +1,5 @@
+Term	es	nes	pval	sidak	fdr	geneset_size	leading_edge	leading_edge_size
+EF-Hand 1, calcium-binding site [IPR018247]	0.4848473060530116	2.311894939838008	0.0207834736545162	0.4893545060170387	0.0288161496272573	39	P0DP25,P41208,Q9BRK5,Q14257,O75340,Q02818,Q9Y680,P80303,O43852,Q9NWM8,O95202,O95302,Q6NUK1	13
+Aminotransferase, class-II, pyridoxal-phosphate binding site [IPR001917]	0.6233766233766327	2.296714731608255	0.0216350485113603	0.5033752462746409	0.0288161496272573	2	O75600	1
+Beta tubulin, autoregulation binding site [IPR013838]	0.6758232737754	1.89869357655522	0.057604776616482	0.8502184094885572	0.0614450950575808	5	P07437,Q13885,P04350	3
+Peptidase M16, zinc-binding site [IPR001431]	0.5060663955335168	1.0029325886340388	0.3158933876335872	0.9999947038384684	0.32608349691209	5	P22695,Q10713	2

interpro_binding_site/selections.json

@@ -0,0 +1 @@
+{"all_annotations": ["2-oxo acid dehydrogenase, lipoyl-binding site [IPR003016]", "2Fe-2S ferredoxin, iron-sulphur binding site [IPR006058]", "6-phosphogluconate-binding site [IPR006184]", "AP endonuclease 1, binding site [IPR020847]", "APOBEC/CMP deaminase, zinc-binding [IPR016192]", "Aconitase family, 4Fe-4S cluster binding site [IPR018136]", "Adenylosuccinate synthase, GTP-binding site [IPR018220]", "Aminotransferase class-V, pyridoxal-phosphate binding site [IPR020578]", "Aminotransferase, class-II, pyridoxal-phosphate binding site [IPR001917]", "Aminotransferases, class-I, pyridoxal-phosphate-binding site [IPR004838]", "Beta tubulin, autoregulation binding site [IPR013838]", "Biotin-binding site [IPR001882]", "Copper centre Cu(A) [IPR001505]", "Cytochrome b5, heme-binding site [IPR018506]", "Cytochrome c oxidase, subunit Vb, zinc binding site [IPR020893]", "EF-Hand 1, calcium-binding site [IPR018247]", "Fumarate reductase/succinate dehydrogenase, FAD-binding site [IPR003952]", "Hexokinase, binding site [IPR019807]", "IQ motif, EF-hand binding site [IPR000048]", "Inositol monophosphatase, metal-binding site [IPR020583]", "Legume lectin, beta chain, Mn/Ca-binding site [IPR019825]", "Manganese/iron superoxide dismutase, binding site [IPR019833]", "PPM-type phosphatase, divalent cation binding [IPR000222]", "Peptidase M16, zinc-binding site [IPR001431]", "Peptidase M24A, methionine aminopeptidase, subfamily 2, binding site [IPR018349]", "Porphobilinogen deaminase, dipyrromethane cofactor binding site [IPR022419]", "Protein kinase, ATP binding site [IPR017441]", "RNA polymerases, subunit N, zinc binding site [IPR020789]", "Serine hydroxymethyltransferase, pyridoxal phosphate binding site [IPR019798]", "Sigma-54 interaction domain, ATP-binding site 1 [IPR025662]", "Transketolase binding site [IPR020826]", "Ureohydrolase, manganese-binding site [IPR020855]"], "available_proteins": ["ACACA", "ACO1", "ACO2", "ACTN1", "ACTN4", "ADSS", "AKT2", "APEX1", "ARG2", "AURKB", "BPNT1", "CALM3", "CALU", "CAMK1", "CAMK2G", "CAPN1", "CAPNS1", "CDK1", "CDK12", "CDK2", "CDK4", "CDK5", "CDK6", "CDK9", "CETN2", "CHUK", "CIT", "COX2", "COX5B", "CSK", "CSNK1A1", "CSNK2A2", "CYB5B", "DBT", "DCTD", "DLAT", "DLST", "DST", "EHD1", "EHD4", "EIF2AK2", "EPHA7", "EPS15", "FKBP10", "FKBP14", "FKBP7", "FKBP9", "GCAT", "GOT1", "GOT2", "GPD2", "GSK3A", "GSK3B", "HASPIN", "HK1", "HK2", "HMBS", "IDE", "IGF1R", "ILKAP", "IMPA1", "IQGAP1", "IQGAP2", "IQGAP3", "LETM1", "LPCAT2", "LRP2", "LYN", "MACF1", "MAP2K1", "MAP2K2", "MAP4K4", "MAPK1", "MAPK14", "MAPK3", "MCCC1", "METAP2", "MICU1", "MYH10", "MYH14", "MYH9", "MYO18A", "MYO1B", "MYO1C", "MYO1D", "MYO5A", "NRDC", "NUCB1", "NUCB2", "PA2G4", "PAK2", "PC", "PCCA", "PDCD6", "PDHX", "PEF1", "PGD", "PKMYT1", "PKN1", "PKN2", "PLCG1", "PLK1", "PLS1", "PLS3", "PMPCA", "PMPCB", "POLR2L", "PPM1G", "PRKACA", "PRKCA", "PRKCSH", "PSAT1", "PTK2", "RAB18", "RCN1", "RCN2", "REPS1", "RHOT1", "RHOT2", "ROCK2", "RPS6KA1", "RPS6KA3", "S100A11", "SDF4", "SDHA", "SDHB", "SHMT1", "SHMT2", "SLC25A12", "SLC25A24", "SLK", "SOD2", "SPTAN1", "SPTLC2", "SRI", "SRPK1", "STK26", "STK3", "STK4", "TKT", "TTK", "TUBB", "TUBB2A", "TUBB2B", "TUBB4A", "TUBB6", "UBE3C", "UQCRC2", "VRK1"], "leading_proteins": ["CALM3", "CALU", "CETN2", "FKBP14", "FKBP7", "FKBP9", "GCAT", "LETM1", "NUCB1", "NUCB2", "PDCD6", "PMPCA", "RCN2", "SDF4", "SLC25A24", "TUBB", "TUBB2A", "TUBB4A", "UQCRC2"]}

interpro_conserved_site/advanced/idx2term.json

@@ -0,0 +1 @@
+{}

interpro_conserved_site/basic/idx2term.json

@@ -0,0 +1 @@
+{}

interpro_conserved_site/consensus.joblib

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+version https://git-lfs.github.com/spec/v1
+oid sha256:388e5ec141147a003e5969f9920f76d8b76c582192f8cdb52e3e7c993905b604
+size 157647

interpro_conserved_site/df_merge.tsv

@@ -0,0 +1,2 @@
+term	overlap	setsize	score	pval	overlap_mean	setsize_mean	score_mean	pval_mean	overlap_std	setsize_std	score_std	pval_std	pval_hit	pval_50	pval_100	pval_250	pval_500
+Syntaxin/epimorphin, conserved site [IPR006012]	4	6	2.125914706100169	0.0335103621583092	2.592233009708738	5.847087378640777	0.9961908981999794	0.2839139128702306	1.4759357288864456	1.4239341993278547	1.138258151200134	0.2914162845337057	0.4536619135514237	1.0	0.1169218221283287	0.2712176839291556	0.4751663030188248

interpro_conserved_site/metrics.json

@@ -0,0 +1,7 @@
+{
+    "type_of_task": "ranksum",
+    "signature_size": 3236,
+    "annotations_size": 286,
+    "title": "Average number of proteins per term",
+    "value": 2.695804195804196
+}

interpro_conserved_site/paths.json

@@ -0,0 +1 @@
+{"results_path": "results/proteins/hek293t_core/interpro_conserved_site/fragment/C228/C228_val_log2fc"}

interpro_conserved_site/result.tsv

@@ -0,0 +1,24 @@
+Term	es	nes	pval	sidak	fdr	geneset_size	leading_edge	leading_edge_size
+Haem oxygenase conserved site [IPR018207]	0.995052566481138	4.208870268071044	2.5665068588143217e-05	0.0073134295765095	0.0002446736538736	2	P09601	1
+Tetraspanin, conserved site [IPR018503]	0.974327250231982	3.81635373161671	0.0001354383014908	0.0379972575958743	0.0007139237043087	3	Q9H1Z9,O60637	2
+Lysosome-associated membrane glycoprotein, conserved site [IPR018134]	0.8259121830550609	3.3947833654165995	0.0006868292348265	0.1783992028138715	0.0024251007550665	2	P13473	1
+C-type lectin, conserved site [IPR018378]	0.7928262213976478	3.2253972158226265	0.0012579799755025	0.3023297872262813	0.0035978227299374	2	Q9UBG0	1
+Sterol reductase, conserved site [IPR018083]	0.8465701538719215	3.2176986958670057	0.0012922348736696	0.3091400626417465	0.0036591997412825	3	Q14739	1
+Quinone oxidoreductase/zeta-crystallin, conserved site [IPR002364]	0.7900074584522341	2.684102375389925	0.0072724833272495	0.8760070078903669	0.0146473959971363	4	Q8N4Q0	1
+Immunoglobulin/major histocompatibility complex, conserved site [IPR003006]	0.713642988916083	2.5431606235777844	0.0109854716217507	0.957541563438797	0.0201400313065431	3	P55899	1
+Sulfatase, conserved site [IPR024607]	0.6387256418187335	2.1369073536268286	0.0326055277814083	0.999923681466292	0.0473359438856994	3	P15586,P15289	2
+Syntaxin/epimorphin, conserved site [IPR006012]	0.7625676035227617	2.125914706100169	0.0335103621583092	0.9999416017532602	0.048149512201159	6	Q86Y82,O15400,Q9P2W9,Q13277	4
+Dynamin, GTPase region, conserved site [IPR019762]	0.6210723884909621	2.038337059743792	0.041516236054873	0.9999945894484488	0.0573605966748488	3	P50570	1
+Clathrin adaptor complex, small chain [IPR000804]	0.572665429808281	1.9973229649075064	0.0457901102110509	0.999998492840404	0.0623617691445741	2	P61923	1
+Tubulin, conserved site [IPR017975]	0.6758232737754	1.89869357655522	0.057604776616482	0.999999957277192	0.0752281557639902	5	P07437,Q13885,P04350	3
+Guanylate kinase, conserved site [IPR020590]	0.7113297685629467	1.8800869630701331	0.0600962269437665	0.9999999799621836	0.0763889818040766	6	Q00013,Q9NZW5,O14936,Q14168	4
+Dynein light chain, type 1/2, conserved site [IPR019763]	0.5442176870748233	1.8250193584077048	0.067998108108026	0.9999999982085568	0.0849234013925566	2	P63167	1
+Intermediate filament protein, conserved site [IPR018039]	0.6666579217976284	1.8092151116209136	0.0704175908358804	0.9999999991481984	0.0868078921511284	8	P08670,P48681,Q16352,P07196	4
+3-hydroxyacyl-CoA dehydrogenase, conserved site [IPR006180]	0.566176074860063	1.7251041917454215	0.084508697271989	0.999999999989208	0.1019809595771682	3	P40939	1
+Profilin conserved site [IPR027310]	0.5037105751391391	1.5747024707276356	0.1153251372609762	0.9999999999999994	0.1362933440356992	2	P35080	1
+Polyamine biosynthesis domain, conserved site [IPR030373]	0.5027829313543525	1.5689080563201898	0.116669364402258	0.9999999999999996	0.1373145605722049	2	P19623	1
+Proteasome beta-type subunit, conserved site [IPR016050]	0.59232404014647	1.416580041198179	0.1566057472790532	1.0	0.1806017892008436	8	P28072,P49721,P20618,P28074	4
+Short-chain dehydrogenase/reductase, conserved site [IPR020904]	0.4179896548279676	0.627175793277042	0.5305440088866136	1.0	0.5578514211087187	11	Q9Y394,Q06136,Q53GQ0,Q8NBN7	4
+Thioredoxin, conserved site [IPR017937]	0.3670295863812048	0.3415472205905552	0.7326916627114193	1.0	0.7537763148757767	11	Q9H1E5,Q9H3N1	2
+ABC transporter-like, conserved site [IPR017871]	0.3563578017306485	0.2857640784891153	0.775058822520297	1.0	0.7945047427985841	11	P08183,Q03518,O75027	3
+Actin/actin-like conserved site [IPR020902]	0.3102381688833946	0.2612218288021988	0.7939214454181509	1.0	0.8080481615287942	3	P61163,P61158	2

interpro_conserved_site/selections.json

@@ -0,0 +1 @@
+{"all_annotations": ["14-3-3 protein, conserved site [IPR023409]", "3-hydroxyacyl-CoA dehydrogenase, conserved site [IPR006180]", "3-hydroxyisobutyrate dehydrogenase-related, conserved site [IPR002204]", "4Fe-4S ferredoxin, iron-sulphur binding, conserved site [IPR017900]", "ABC transporter-like, conserved site [IPR017871]", "AMP-binding, conserved site [IPR020845]", "AP endonuclease 1, conserved site [IPR020848]", "AT hook, DNA-binding motif [IPR017956]", "ATP synthase, F1 complex, gamma subunit conserved site [IPR023632]", "ATP-citrate lyase/succinyl-CoA ligase, conserved site [IPR033847]", "ATP-dependent RNA helicase DEAD-box, conserved site [IPR000629]", "ATPase, AAA-type, conserved site [IPR003960]", "ATPase, OSCP/delta subunit, conserved site [IPR020781]", "Acin1, RNSP1-SAP18 binding (RSB) motif [IPR032552]", "Actin, conserved site [IPR004001]", "Actin/actin-like conserved site [IPR020902]", "Actinin-type actin-binding domain, conserved site [IPR001589]", "Acyl-CoA dehydrogenase, conserved site [IPR006089]", "Acyl-CoA-binding protein, ACBP, conserved site [IPR022408]", "Adenylate kinase, conserved site [IPR033690]", "Alanine dehydrogenase/NAD(P) transhydrogenase, conserved site-1 [IPR008142]", "Alanine dehydrogenase/pyridine nucleotide transhydrogenase, conserved site-2 [IPR008143]", "Alcohol dehydrogenase, zinc-type, conserved site [IPR002328]", "Aldehyde dehydrogenase, cysteine active site [IPR016160]", "Aldehyde dehydrogenase, glutamic acid active site [IPR029510]", "Aldo/keto reductase, conserved site [IPR018170]", "Aldose 1-epimerase, conserved site [IPR018052]", "Alpha-2-macroglobulin, conserved site [IPR019742]", "Alpha-D-phosphohexomutase, conserved site [IPR016066]", "Aminoacyl-tRNA synthetase, class I, conserved site [IPR001412]", "Aminotransferase, class IV, conserved site [IPR018300]", "Amyloidogenic glycoprotein,  copper-binding domain conserved site [IPR019744]", "Amyloidogenic glycoprotein, intracellular domain, conserved site [IPR019745]", "Anion exchange, conserved site [IPR018241]", "Annexin repeat, conserved site [IPR018252]", "Apoptosis regulator, Bcl-2, BH1 motif, conserved site [IPR020717]", "Apoptosis regulator, Bcl-2, BH2 motif, conserved site [IPR020726]", "Apoptosis regulator, Bcl-2, BH3 motif, conserved site [IPR020728]", "ArgE/DapE/ACY1/CPG2/YscS, conserved site [IPR001261]", "Arrestin, conserved site [IPR017864]", "BUD31/G10-related, conserved site [IPR018230]", "Bacterial Fmu (Sun)/eukaryotic nucleolar NOL1/Nop2p, conserved site [IPR018314]", "Band 7/stomatin-like, conserved site [IPR018080]", "Bax inhibitor 1, conserved site [IPR006213]", "Bromodomain, conserved site [IPR018359]", "C-type lectin, conserved site [IPR018378]", "CAP, conserved site, C-terminal [IPR028417]", "CAP, conserved site, N-terminal [IPR018106]", "CBX family C-terminal motif [IPR033773]", "Cadherin conserved site [IPR020894]", "Calreticulin/calnexin, conserved site [IPR018124]", "Carbohydrate/purine kinase, PfkB, conserved site [IPR002173]", "Chaperonin Cpn60, conserved site [IPR018370]", "Chaperonin GroES, conserved site [IPR018369]", "Chaperonin TCP-1, conserved site [IPR002194]", "Chromo domain, conserved site [IPR023779]", "Clathrin adaptor complex, small chain [IPR000804]", "Clathrin adaptor, mu subunit, conserved site [IPR018240]", "Clusterin, conserved site [IPR033986]", "Copper type II, ascorbate-dependent monooxygenase, histidine-cluster-1 conserved site [IPR020611]", "Copper type II, ascorbate-dependent monooxygenase, histidine-cluster-2 conserved site [IPR014783]", "Coproporphyrinogen III oxidase, conserved site [IPR018375]", "Cullin, conserved site [IPR016157]", "Cyclic nucleotide-binding, conserved site [IPR018488]", "Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site [IPR020892]", "Cytochrome P450, conserved site [IPR017972]", "D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site 1 [IPR029752]", "D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site [IPR029753]", "DNA ligase, ATP-dependent, conserved site [IPR016059]", "DNA methylase, C-5 cytosine-specific,  conserved site [IPR031303]", "DNA methylase, N-6 adenine-specific, conserved site [IPR002052]", "DNA mismatch repair, conserved site [IPR014762]", "DNA topoisomerase, type IIA, conserved site [IPR018522]", "DNA-directed DNA polymerase, family A, conserved site [IPR019760]", "DNA-directed DNA polymerase, family B, conserved site [IPR017964]", "DNA-directed RNA polymerase, 30-40kDa subunit, conserved site [IPR001514]", "DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site [IPR002464]", "Dihydrofolate reductase conserved site [IPR017925]", "Dihydroorotase, conserved site [IPR002195]", "DnaJ domain, conserved site [IPR018253]", "Dpy-30 motif [IPR007858]", "Dynamin, GTPase region, conserved site [IPR019762]", "Dynein light chain, type 1/2, conserved site [IPR019763]", "EGF-like calcium-binding, conserved site [IPR018097]", "EGF-like, conserved site [IPR013032]", "Electron transfer flavoprotein subunit alpha, conserved site [IPR018206]", "Electron transfer flavoprotein, beta-subunit, conserved site [IPR000049]", "Enolase, conserved site [IPR020809]", "Enoyl-CoA hydratase/isomerase, conserved site [IPR018376]", "Ependymin, conserved site [IPR018224]", "Eukaryotic translation initiation factor 4E (eIF-4E), conserved site [IPR019770]", "F-actin capping protein, alpha subunit, conserved site [IPR017865]", "F-actin capping protein, beta subunit, conserved site [IPR019771]", "FERM conserved site [IPR019747]", "FLAP/GST2/LTC4S, conserved site [IPR018295]", "Fatty acid desaturase type 1, conserved site [IPR001522]", "Ferritin, conserved site [IPR014034]", "Fibrillarin, conserved site [IPR020813]", "Fork head domain conserved site 2 [IPR030456]", "Fork head domain conserved site1 [IPR018122]", "Formate-tetrahydrofolate ligase, FTHFS, conserved site [IPR020628]", "Fructose-bisphosphate aldolase class-I active site [IPR029768]", "Fumarate lyase, conserved site [IPR020557]", "GHMP kinase, ATP-binding, conserved site [IPR006203]", "GTP1/OBG, conserved site [IPR006074]", "Galactokinase, conserved site [IPR019741]", "Gamma-glutamyl phosphate reductase GPR, conserved site [IPR020593]", "Glucosamine-6-phosphate isomerase, conserved site [IPR018321]", "Glutamate 5-kinase, conserved site [IPR019797]", "Glutamyl-tRNA(Gln) amidotransferase, subunit B, conserved site [IPR017958]", "Glutathione peroxidase conserved site [IPR029760]", "Glycoside hydrolase family 27/36, conserved site [IPR000111]", "Glycoside hydrolase, family 2, conserved site [IPR023230]", "Glycoside hydrolase, family 29, conserved site [IPR018526]", "Glycoside hydrolase, family 35, conserved site [IPR019801]", "Glycosyl hydrolases family 31, conserved site [IPR030459]", "Glyoxalase I, conserved site [IPR018146]", "Golgin subfamily A member 2, C-terminal binding motif [IPR043937]", "Guanine-nucleotide dissociation stimulator, CDC24, conserved site [IPR001331]", "Guanylate kinase, conserved site [IPR020590]", "HIND motif [IPR045347]", "HMG box A DNA-binding domain, conserved site [IPR017967]", "HMG-I/HMG-Y, DNA-binding, conserved site [IPR000637]", "Haem oxygenase conserved site [IPR018207]", "Heat shock protein 70, conserved site [IPR018181]", "Heat shock protein Hsp90, conserved site [IPR019805]", "Heavy-metal-associated, conserved site [IPR017969]", "Helix-hairpin-helix motif, class 2 [IPR008918]", "Hexapeptide transferase, conserved site [IPR018357]", "Histidine triad, conserved site [IPR019808]", "Histone H2A conserved site [IPR032458]", "Histone H4, conserved site [IPR019809]", "IMP dehydrogenase / GMP reductase, conserved site [IPR015875]", "Immunoglobulin/major histocompatibility complex, conserved site [IPR003006]", "Inositol monophosphatase, conserved site [IPR020550]", "Integrin alpha chain, C-terminal cytoplasmic region, conserved site [IPR018184]", "Intermediate filament protein, conserved site [IPR018039]", "Isocitrate/isopropylmalate dehydrogenase, conserved site [IPR019818]", "Kinesin motor domain, conserved site [IPR019821]", "Lipocalin family conserved site [IPR022272]", "Low-density lipoprotein (LDL) receptor class A, conserved site [IPR023415]", "Lysophospholipase patatin, conserved site [IPR001423]", "Lysosome-associated membrane glycoprotein, conserved site [IPR018134]", "Macrophage migration inhibitory factor, conserved site [IPR019829]", "Malic enzyme, conserved site [IPR015884]", "Methylthiotransferase, conserved site [IPR020612]", "Mini-chromosome maintenance, conserved site [IPR018525]", "Mitogen-activated protein (MAP) kinase, conserved site [IPR003527]", "MnmG-related, conserved site [IPR020595]", "Mrp, conserved site [IPR000808]", "Myristoyl-CoA:protein N-myristoyltransferase, conserved site [IPR022678]", "NADH:ubiquinone oxidoreductase, 30kDa subunit, conserved site [IPR020396]", "NADH:ubiquinone oxidoreductase, 49kDa subunit, conserved site [IPR014029]", "NADH:ubiquinone oxidoreductase, 51kDa subunit, conserved site [IPR001949]", "NADH:ubiquinone oxidoreductase, 75kDa subunit, conserved site [IPR000283]", "NADH:ubiquinone oxidoreductase, subunit 1, conserved site [IPR018086]", "NUDIX hydrolase, conserved site [IPR020084]", "Oxysterol-binding protein, conserved site [IPR018494]", "P-type trefoil, conserved site [IPR017957]", "Peptidase M22, conserved site [IPR017860]", "Peptidase M24B, X-Pro dipeptidase/aminopeptidase P, conserved site [IPR001131]", "Peptidase S26A, signal peptidase I, conserved site [IPR019758]", "Peptidyl-prolyl cis-trans isomerase, PpiC-type, conserved site [IPR023058]", "Phosphatidylethanolamine-binding, conserved site [IPR001858]", "Phosphatidylinositol 3/4-kinase, conserved site [IPR018936]", "Phosphoenolpyruvate carboxykinase, GTP-utilising, conserved site [IPR018091]", "Phosphofructokinase, conserved site [IPR015912]", "Phosphoglucose isomerase, conserved site [IPR018189]", "Phosphoglycerate kinase, conserved site [IPR015911]", "Phosphomannose isomerase, type I, conserved site [IPR018050]", "Phosphoribosyl pyrophosphate synthetase, conserved site [IPR000842]", "Phosphoribosylglycinamide synthetase, conserved site [IPR020559]", "Phosphorylase pyridoxal-phosphate attachment site [IPR035090]", "Polyamine biosynthesis domain, conserved site [IPR030373]", "Polyprenyl synthetase, conserved site [IPR033749]", "Procollagen-lysine 5-dioxygenase, conserved site [IPR001006]", "Profilin conserved site [IPR027310]", "Proliferating cell nuclear antigen, PCNA, conserved site [IPR022659]", "Proteasome beta-type subunit, conserved site [IPR016050]", "Protein phosphatase 2A regulatory subunit PR55, conserved site [IPR018067]", "Proteinase inhibitor I2, Kunitz, conserved site [IPR020901]", "Proteinase inhibitor I25, cystatin, conserved site [IPR018073]", "Pseudouridine synthase TruD, conserved site [IPR020119]", "Purine phosphorylase, family 2, conserved site [IPR018099]", "Quinone oxidoreductase/zeta-crystallin, conserved site [IPR002364]", "RNA 3'-terminal phosphate cyclase-like, conserved site [IPR020719]", "RNA polymerase, beta subunit, conserved site [IPR007121]", "Ras GTPase-activating protein, conserved site [IPR023152]", "Retro-transposon transporting motif [IPR018892]", "Ribonuclease II/R, conserved site [IPR022966]", "Ribosomal RNA adenine methylase transferase, conserved site [IPR020596]", "Ribosomal S11, conserved site [IPR018102]", "Ribosomal S24e conserved site [IPR018098]", "Ribosomal protein L1, conserved site [IPR023673]", "Ribosomal protein L10e, conserved site [IPR018255]", "Ribosomal protein L11, conserved site [IPR020785]", "Ribosomal protein L13, conserved site [IPR023563]", "Ribosomal protein L13e, conserved site [IPR018256]", "Ribosomal protein L14P,  conserved site [IPR019972]", "Ribosomal protein L15, conserved site [IPR001196]", "Ribosomal protein L15e, conserved site [IPR020925]", "Ribosomal protein L18e, conserved site [IPR021132]", "Ribosomal protein L19/L19e conserved site [IPR023638]", "Ribosomal protein L2, conserved site [IPR022671]", "Ribosomal protein L21e, conserved site [IPR018259]", "Ribosomal protein L22/L17, conserved site [IPR018260]", "Ribosomal protein L23/L25, conserved site [IPR001014]", "Ribosomal protein L24/L26, conserved site [IPR005825]", "Ribosomal protein L24e, conserved site [IPR023442]", "Ribosomal protein L27e, conserved site [IPR018262]", "Ribosomal protein L29, conserved site [IPR018254]", "Ribosomal protein L3, conserved site [IPR019926]", "Ribosomal protein L30, conserved site [IPR018038]", "Ribosomal protein L30e, conserved site [IPR022991]", "Ribosomal protein L31e, conserved site [IPR020052]", "Ribosomal protein L32e, conserved site [IPR018263]", "Ribosomal protein L34e, conserved site [IPR018065]", "Ribosomal protein L35Ae, conserved site [IPR018266]", "Ribosomal protein L37e, conserved site [IPR018267]", "Ribosomal protein L4/L1e, eukaryotic/archaeal, conserved site [IPR013000]", "Ribosomal protein L5, conserved site [IPR020929]", "Ribosomal protein L6, conserved site-2 [IPR002359]", "Ribosomal protein L7Ae conserved site [IPR004037]", "Ribosomal protein S10, conserved site [IPR018268]", "Ribosomal protein S13, conserved site [IPR018269]", "Ribosomal protein S14, conserved site [IPR018271]", "Ribosomal protein S17, conserved site [IPR019979]", "Ribosomal protein S17e, conserved site [IPR018273]", "Ribosomal protein S19 conserved site [IPR020934]", "Ribosomal protein S19e, conserved site [IPR018277]", "Ribosomal protein S2, conserved site [IPR018130]", "Ribosomal protein S28e conserved site [IPR028626]", "Ribosomal protein S3, conserved site [IPR018280]", "Ribosomal protein S3Ae, conserved site [IPR018281]", "Ribosomal protein S4, conserved site [IPR018079]", "Ribosomal protein S4e, N-terminal, conserved site [IPR018199]", "Ribosomal protein S5, N-terminal, conserved site [IPR018192]", "Ribosomal protein S6e, conserved site [IPR018282]", "Ribosomal protein S7, conserved site [IPR020606]", "Ribosomal protein S8e, conserved site [IPR018283]", "Ribosomal protein S9, conserved site [IPR020574]", "Ribosome maturation protein SBDS, conserved site [IPR018023]", "RidA, conserved site [IPR019897]", "S-adenosyl-L-homocysteine hydrolase, conserved site [IPR020082]", "S-adenosylmethionine synthetase, conserved site [IPR022631]", "S100/Calbindin-D9k, conserved site [IPR001751]", "SAICAR synthetase, conserved site [IPR018236]", "SecY conserved site [IPR030659]", "Serpin, conserved site [IPR023795]", "Short-chain dehydrogenase/reductase, conserved site [IPR020904]", "Sodium/solute symporter, conserved site [IPR018212]", "Sodium:dicarboxylate symporter, conserved site [IPR018107]", "Squalene/phytoene synthase, conserved site [IPR019845]", "Stathmin, conserved site [IPR030514]", "Sterol reductase, conserved site [IPR018083]", "Succinyl-CoA synthetase, beta subunit, conserved site [IPR017866]", "Sugar transporter, conserved site [IPR005829]", "Sulfatase, conserved site [IPR024607]", "Syntaxin/epimorphin, conserved site [IPR006012]", "TPP-binding enzyme, conserved site [IPR000399]", "Terpene synthase, conserved site [IPR002365]", "Tetrahydrofolate dehydrogenase/cyclohydrolase, conserved site [IPR020867]", "Tetraspanin, conserved site [IPR018503]", "Thiolase, conserved site [IPR020613]", "Thioredoxin, conserved site [IPR017937]", "Thiosulphate sulfurtransferase, conserved site [IPR001307]", "Thymidine kinase, conserved site [IPR020633]", "Thymidylate kinase, conserved site [IPR018095]", "Tr-type G domain, conserved site [IPR031157]", "Translation elongation factor EF1B, beta/delta chains, conserved site [IPR001326]", "Translation elongation factor Ts, conserved site [IPR018101]", "Translationally controlled tumour protein, conserved site [IPR018103]", "Tubulin, conserved site [IPR017975]", "Tyrosine-protein kinase, receptor class II, conserved site [IPR002011]", "Tyrosine-protein kinase, receptor class V, conserved site [IPR001426]", "UbiE/COQ5 methyltransferase, conserved site [IPR023576]", "Ubiquitin conserved site [IPR019954]", "Ubiquitin interacting motif [IPR003903]", "Ubiquitin specific protease, conserved site [IPR018200]", "Ubiquitin-activating enzyme E1, conserved site [IPR018074]", "Vinculin, conserved site [IPR000633]", "WD40 repeat, conserved site [IPR019775]", "XPG conserved site [IPR019974]", "Zinc finger, PHD-type, conserved site [IPR019786]", "Zinc finger, RING-type, conserved site [IPR017907]", "tRNA-dihydrouridine synthase, conserved site [IPR018517]"], "available_proteins": ["AAAS", "AAMP", "ABCB1", "ABCB10", "ABCB7", "ABCC1", "ABCC4", "ABCD3", "ABCE1", "ABCF1", "ABCF2", "ABCF3", "ACAA1", "ACAA2", "ACAD9", "ACADM", "ACADS", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACIN1", "ACLY", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACSL6", "ACTL6A", "ACTN1", "ACTN4", "ACTR1A", "ACTR2", "ACTR3", "ADH5", "ADK", "ADSL", "AFG3L2", "AHCY", "AHCYL1", "AK1", "AK2", "AK3", "AK4", "AKR1A1", "AKR1B1", "ALDH18A1", "ALDH1A2", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ANXA1", "ANXA11", "ANXA2", "ANXA6", "ANXA7", "AP1M1", "AP2M1", "AP2S1", "AP3M1", "APEX1", "APP", "ARHGEF7", "ARRB1", "ARSA", "ATAD1", "ATAD2", "ATM", "ATP5C1", "ATP5O", "ATP7B", "BAG6", "BAK1", "BAZ1A", "BAZ1B", "BCAT2", "BCR", "BCS1L", "BLM", "BOP1", "BPNT1", "BPTF", "BRCA1", "BRD2", "BUD31", "CAD", "CALR", "CANX", "CAP1", "CAPZA1", "CAPZA2", "CAPZB", "CASK", "CBR1", "CBX1", "CBX2", "CBX3", "CBX5", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD109", "CD320", "CDC40", "CDH2", "CDKAL1", "CETN2", "CHAF1B", "CHD1", "CHD1L", "CHD3", "CHD4", "CLGN", "CLU", "CMPK1", "CNDP2", "COLEC12", "COPA", "COPZ1", "CORO1B", "CORO1C", "CORO7", "CPOX", "CRYZ", "CSTB", "CSTF1", "CTBP1", "CTBP2", "CTNNA1", "CUL1", "CUL2", "CUL3", "CUL4A", "CUL4B", "CUL5", "CWC27", "CYP51A1", "DCAF13", "DCP2", "DCPS", "DCXR", "DDT", "DDX10", "DDX17", "DDX18", "DDX20", "DDX23", "DDX24", "DDX27", "DDX3X", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX51", "DDX54", "DDX6", "DHCR7", "DHFR", "DHRS7", "DHRS7B", "DHX15", "DHX16", "DHX29", "DHX30", "DHX36", "DHX38", "DHX8", "DHX9", "DIDO1", "DIMT1", "DIS3", "DLG3", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJB11", "DNAJB4", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC16", "DNAJC2", "DNAJC9", "DNM1L", "DNM2", "DNM3", "DNMT1", "DPY30", "DRG1", "DRG2", "DSC3", "DSG2", "DST", "DTYMK", "DUS2", "DYNLL1", "DYNLL2", "EARS2", "ECH1", "ECHS1", "ECI1", "ECI2", "EED", "EEF1A2", "EEF1B2", "EEF1D", "EEF2", "EHHADH", "EIF3I", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4E", "ENO1", "ENO2", "EPB41", "EPB41L2", "EPB41L3", "EPB41L5", "EPDR1", "EPHA7", "EPRS", "EPS15", "ERCC2", "ETFA", "ETFB", "EXO1", "EZR", "FBL", "FCGRT", "FDFT1", "FDPS", "FEN1", "FH", "FLNA", "FLNB", "FLNC", "FOXK2", "FTL", "FUCA1", "FUCA2", "GAA", "GALK1", "GALM", "GANAB", "GART", "GATB", "GCDH", "GEMIN5", "GFM1", "GLA", "GLB1", "GLB1L2", "GLO1", "GMPPA", "GNPDA1", "GNS", "GOLGA2", "GPI", "GPX8", "GRHPR", "GRWD1", "GSPT1", "GTF3C2", "GUF1", "GUSB", "H2AFX", "H4C1*", "HADH", "HADHA", "HADHB", "HIBADH", "HINT2", "HLA-A", "HLA-B", "HLTF", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMOX1", "HMOX2", "HSD17B10", "HSD17B12", "HSD17B4", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA13", "HSPA14", "HSPA1B", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPD1", "HSPE1", "HSPH1", "HYOU1", "IARS", "IARS2", "IDH1", "IDH2", "IDH3A", "IDH3B", "IGF1R", "ILVBL", "IMPA1", "IMPAD1", "IMPDH1", "IMPDH2", "INA", "INTS12", "IQGAP1", "IQGAP2", "IQGAP3", "ITGA6", "ITGAV", "IVD", "KATNA1", "KDM2A", "KDM5A", "KDSR", "KIF11", "KIF14", "KIF18B", "KIF1A", "KIF20A", "KIF20B", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF4A", "KIF5B", "LAMP1", "LAMP2", "LARS", "LARS2", "LBR", "LDLR", "LIG1", "LIG3", "LMNA", "LMNB1", "LMNB2", "LRP1", "LRP2", "LRWD1", "LSS", "MACF1", "MAPK1", "MAPK14", "MAPK3", "MARS", "MAT2A", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "ME1", "ME2", "MGST2", "MID1", "MIF", "MPI", "MPP1", "MPP2", "MPP6", "MPP7", "MPST", "MRC2", "MRPL13", "MRPL24", "MRPL3", "MRPS11", "MRPS2", "MRPS5", "MRPS9", "MSN", "MTAP", "MTHFD1", "MTHFD1L", "MTHFD2", "MTO1", "MTOR", "ND1", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS8", "NDUFV1", "NEFL", "NEFM", "NES", "NF1", "NLE1", "NMT1", "NNT", "NOP2", "NSD2", "NSF", "NUBP2", "NUDT1", "NUDT5", "NUP153", "NUP37", "NUP43", "NVL", "OSBP", "OSBPL11", "OSBPL1A", "OSBPL3", "OSBPL8", "OSBPL9", "OSGEP", "P4HB", "PAFAH1B1", "PAICS", "PAK1IP1", "PAM", "PBRM1", "PCK2", "PCNA", "PDIA3", "PDIA4", "PDIA6", "PEBP1", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGK1", "PGM1", "PGM2", "PHF3", "PHF8", "PHGDH", "PHIP", "PI4KA", "PI4KB", "PIN1", "PLEC", "PLOD1", "PLOD2", "PLOD3", "PLRG1", "PLS1", "PLS3", "PNP", "PNPLA6", "POLA1", "POLD1", "POLG", "POLR1B", "POLR1C", "POLR2B", "POLR2C", "POLR3B", "PPIB", "PPIC", "PPID", "PPIE", "PPIF", "PPIH", "PPIL1", "PPIL3", "PPP2R2A", "PRKAR1A", "PRKAR2A", "PRKDC", "PRPF19", "PRPF4", "PRPS2", "PSMA4", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD4", "PUS7", "PWP2", "PYGB", "PYGL", "QARS", "QDPR", "RACK1", "RAE1", "RANBP2", "RARS", "RARS2", "RASAL2", "RBBP4", "RBBP7", "RCL1", "RDH13", "RDX", "RIDA", "RNF169", "RNF2", "RNF20", "RNF40", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL15", "RPL17", "RPL18", "RPL19", "RPL21", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL37", "RPL4", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPS11", "RPS14", "RPS15", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS24", "RPS28", "RPS29", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS8", "RPS9", "RPSA", "RRP8", "RRP9", "RSF1", "RTCA", "RTN4IP1", "S100A10", "S100A11", "SART1", "SBDS", "SCAF11", "SCD", "SCP2", "SDHB", "SEC11A", "SEC61A1", "SERPINB6", "SERPINH1", "SGSH", "SLC1A5", "SLC25A42", "SLC27A2", "SLC27A4", "SLC2A1", "SLC4A2", "SLC5A6", "SLIT2", "SMARCA4", "SMS", "SMU1", "SNRNP40", "SNU13", "SPATA5", "SPATA5L1", "SPTBN1", "SPTBN2", "SRCAP", "SRM", "STAM2", "STMN1", "STOM", "STRN", "STX10", "STX12", "STX18", "STX3", "STX5", "STX7", "SUCLA2", "SUCLG1", "SUCLG2", "SV2A", "SYNE1", "SYNE2", "TAP1", "TBL3", "TCP1", "TFB1M", "TK1", "TLE3", "TLN1", "TM7SF2", "TMBIM6", "TMX1", "TMX3", "TMX4", "TOP2A", "TOP2B", "TPT1", "TRIM21", "TRIM24", "TRIM25", "TRIM28", "TRIM33", "TRIP13", "TRMT11", "TSFM", "TSPAN10", "TSPAN3", "TSPAN6", "TTF2", "TUBB", "TUBB2A", "TUBB2B", "TUBB4A", "TUBB6", "TUFM", "TXNDC12", "TXNDC5", "TXNL1", "UBA1", "UBA2", "UBA5", "UBFD1", "UHRF1", "USP10", "USP14", "USP15", "USP19", "USP24", "USP28", "USP34", "USP47", "USP48", "USP5", "USP7", "USP8", "USP9X", "UTP15", "UTP18", "UTRN", "VARS1", "VARS2", "VAT1", "VCL", "VCP", "VIM", "VPS4A", "VPS4B", "WARS", "WARS2", "WDHD1", "WDR1", "WDR11", "WDR12", "WDR18", "WDR3", "WDR36", "WDR5", "WDR61", "WDR77", "XPNPEP1", "YARS2", "YME1L1", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2", "ZMYND8"], "leading_proteins": ["ABCB1", "ABCB7", "ACTR1A", "ACTR3", "ARSA", "CASK", "COPZ1", "DHRS7", "DNM2", "DYNLL1", "FCGRT", "GNS", "HADHA", "HMOX1", "HSD17B12", "INA", "KDSR", "LAMP2", "LBR", "MPP1", "MPP2", "MPP6", "MRC2", "NEFL", "NES", "PFN2", "PSMB1", "PSMB2", "PSMB5", "PSMB6", "RDH13", "SRM", "STX12", "STX18", "STX3", "STX7", "TAP1", "TMX1", "TMX4", "TSPAN10", "TSPAN3", "TUBB", "TUBB2A", "TUBB4A", "VIM", "ZADH2"]}

interpro_domain/advanced/idx2term.json

@@ -0,0 +1 @@
+{"0": "EF-hand domain [IPR002048]", "1": "P-type ATPase, haloacid dehalogenase domain [IPR044492]"}

interpro_domain/basic/idx2term.json

@@ -0,0 +1 @@
+{"0": "EF-hand domain [IPR002048]", "1": "P-type ATPase, haloacid dehalogenase domain [IPR044492]", "2": "Phospholipid/glycerol acyltransferase [IPR002123]", "3": "Cytochrome b5-like heme/steroid binding domain [IPR001199]", "4": "Band 7 domain [IPR001107]", "5": "Immunoglobulin-like domain [IPR007110]", "6": "Ubiquitin-associated domain [IPR015940]", "7": "Small GTP-binding protein domain [IPR005225]", "8": "PDZ domain [IPR001478]"}

interpro_domain/consensus.joblib

@@ -0,0 +1,3 @@
+version https://git-lfs.github.com/spec/v1
+oid sha256:bf24316350e07630b516a27cf30982d2856b49080c230a49d2db66df6239df53
+size 933639

interpro_domain/df_merge.tsv

@@ -0,0 +1,9 @@
+term	overlap	setsize	score	pval	overlap_mean	setsize_mean	score_mean	pval_mean	overlap_std	setsize_std	score_std	pval_std	pval_hit	pval_50	pval_100	pval_250	pval_500
+TRAM/LAG1/CLN8 homology domain [IPR006634]	3	5	2.940330229207669	0.0032786261510173	1.691747572815534	3.3592233009708736	1.3447142040916915	0.1822595206051251	1.014281444620711	0.9789470163478144	1.2723870690026748	0.2262567589818981	0.0007082502643766	0.0461123069087121	0.0038356556834428	6.0962037274720464e-05	0.0008979958332773
+EF-hand domain [IPR002048]	20	48	2.86988479183334	0.0041062137950094	12.385922330097088	43.512135922330096	1.0171858714399242	0.3947118087831401	4.608360476919044	4.087317384177653	1.201458704248258	0.3652478399429377	2.246223103217399e-06	0.0803264485172424	0.0697861672765754	0.0332010767014309	1.173313496533316e-06
+Cation-transporting P-type ATPase, C-terminal [IPR006068]	3	5	2.237309680972541	0.0252661069284307	2.2985436893203883	4.150485436893204	0.5310155053290574	0.3897464493012307	1.1928988171245156	0.7984662222288074	1.1360507856968378	0.3059467081218019	0.0727310464973926	1.0	1.0	0.2159896916124382	0.081185673590516
+Cation-transporting P-type ATPase, N-terminal [IPR004014]	3	5	2.237309680972541	0.0252661069284307	2.2985436893203883	4.150485436893204	0.5310155053290574	0.3897464493012307	1.1928988171245156	0.7984662222288074	1.1360507856968378	0.3059467081218019	0.0727310464973926	1.0	1.0	0.2159896916124382	0.081185673590516
+Glycosyltransferase 2-like [IPR001173]	3	5	2.23686005291557	0.0252954881289313	1.6092233009708738	4.266990291262136	0.4045535360652099	0.4585856527298224	1.1638621588890832	0.9407586640490804	1.0013260543440905	0.3085921397751335	0.1465105393099422	1.0	1.0	1.0	0.1620343535402625
+P-type ATPase, haloacid dehalogenase domain [IPR044492]	6	8	2.23081852030307	0.0256931526503674	2.941747572815534	6.145631067961165	0.9567723497044874	0.2732808833570771	1.8358630293390923	1.459204245106796	1.2102525517005158	0.2943240638910574	0.0160113981900875	1.0	1.0	0.0970188007029606	0.0197371616775071
+Alcohol dehydrogenase, N-terminal [IPR013154]	1	5	2.0169587298791924	0.043699820326456	1.3762135922330097	5.245145631067961	0.6000738304798152	0.3870290227769069	1.1994000251783288	0.9246362329357484	1.1062357688130569	0.3020782188917261	0.0599428693641984	1.0	0.0824659877424542	0.018519525655472	0.0670385451046901
+GOLD domain [IPR009038]	4	6	2.005634665859489	0.0448952405031282	2.8762135922330097	6.247572815533981	0.4192390492462461	0.3068843884052658	1.4199402534298398	0.930533270242389	1.3963570929114475	0.294203492723015	0.0189307613063901	1.0	1.0	0.0376759114543004	0.0223579071158045

interpro_domain/metrics.json

@@ -0,0 +1,7 @@
+{
+    "type_of_task": "ranksum",
+    "signature_size": 3236,
+    "annotations_size": 2625,
+    "title": "Average number of proteins per term",
+    "value": 2.1942857142857144
+}

interpro_domain/paths.json

@@ -0,0 +1 @@
+{"results_path": "results/proteins/hek293t_core/interpro_domain/fragment/C228/C228_val_log2fc"}

interpro_domain/result.tsv

@@ -0,0 +1,211 @@
+Term	es	nes	pval	sidak	fdr	geneset_size	leading_edge	leading_edge_size
+MENTAL domain [IPR019498]	0.935992578849726	3.933817956637859	8.360711475430271e-05	0.1970620584826479	0.0005225444672143	2	O95772	1
+Prenylcysteine lyase [IPR010795]	0.9199134199134292	3.857298804454456	0.0001146469788184	0.2598967475095925	0.0006542354769532	2	Q9UHG3	1
+Prolyl 4-hydroxylase alpha-subunit, N-terminal [IPR013547]	0.900742115027829	3.765108278883596	0.0001664769242555	0.3540533124236488	0.0008137838476178	2	O15460	1
+ATPase family AAA domain-containing protein 3, N-terminal [IPR021911]	0.8747680890538025	3.638497383758085	0.0002742334134815	0.5132289714164785	0.0011160662176574	2	Q9NVI7	1
+Fatty acid hydroxylase [IPR006694]	0.8741496598639631	3.635458369836873	0.0002774868039978	0.5173695057111164	0.0011206197853759	2	Q15800	1
+Complex 1 LYR protein domain [IPR008011]	0.8639455782313123	3.585147469584192	0.0003368877896108	0.5870709288210576	0.0013081811356929	2	Q9NU23	1
+Diacylglycerol kinase, catalytic domain [IPR001206]	0.8596165739022894	3.5637075354715675	0.0003656533468932	0.617113072842779	0.0013712000508495	2	Q9NRA0	1
+Endoplasmic reticulum vesicle transporter, C-terminal [IPR012936]	0.8559059987631623	3.545284579343399	0.0003921894143195	0.6428856157080647	0.001447956698437	2	Q9Y282	1
+Endoplasmic reticulum vesicle transporter, N-terminal [IPR039542]	0.8559059987631623	3.545284579343399	0.0003921894143195	0.6428856157080647	0.001447956698437	2	Q9Y282	1
+Mitochondrial outer membrane transport complex Sam37/metaxin, N-terminal domain [IPR019564]	0.8305504019789925	3.418243325896445	0.000630267332295	0.8089028496918942	0.0020501260808855	2	Q13505	1
+Metaxin, glutathione S-transferase domain [IPR033468]	0.8305504019789925	3.418243325896445	0.000630267332295	0.8089028496918942	0.0020501260808855	2	Q13505	1
+RBM3/CIRBP, RNA recognition motif [IPR034278]	0.8150896722325274	3.3397729637763556	0.0008384690590959	0.8894076680407808	0.0025096707869176	2	Q14011	1
+Exportin-2, central domain [IPR013713]	0.8568302435790596	3.267468227365956	0.0010851404598277	0.9421580121655272	0.0030319513898502	3	O95373	1
+CD209-like, C-type lectin-like domain [IPR033989]	0.7928262213976478	3.2253972158226265	0.0012579799755025	0.9632742167012356	0.0033938308691616	2	Q9UBG0	1
+C-type lectin-like [IPR001304]	0.7928262213976478	3.2253972158226265	0.0012579799755025	0.9632742167012356	0.0033938308691616	2	Q9UBG0	1
+Reticulon [IPR003388]	0.8978960396039691	3.196399406711784	0.0013915433888214	0.9741474302184222	0.0036619200011966	4	O95197,Q9NQC3,O75298	3
+Acyltransferase, C-terminal domain [IPR032098]	0.8381626690017598	3.17668239020649	0.0014897008362171	0.9800271275228454	0.0038416170200496	3	Q9NUQ2	1
+GMP phosphodiesterase, delta subunit [IPR008015]	0.774273345701949	3.1288093685369516	0.0017551613745316	0.9900615740077175	0.0043883733023714	2	Q13432	1
+Tim44-like domain [IPR007379]	0.7739641311069856	3.1271895734581943	0.0017648608730791	0.9903118587833942	0.0043916784621387	2	O43615	1
+Syntaxin, N-terminal domain [IPR006011]	0.8267862666254253	3.120843219039992	0.0018033401542434	0.9912442210060978	0.0044574085733418	3	O15400,Q13277	2
+Far upstream element-binding protein, C-terminal [IPR015096]	0.7714904143475545	3.1142193025693756	0.0018443235126579	0.992138825252678	0.0045501402450442	2	Q92945	1
+Heterogeneous nuclear ribonucleoprotein Q acidic domain [IPR041337]	0.7631416202844745	3.0702875671515812	0.0021385275699501	0.9963740751745436	0.0051516711273328	2	O60506	1
+RBM1CTR [IPR012604]	0.7606679035250435	3.057223952615242	0.0022339730057612	0.9971792123394309	0.0053069494480753	2	P38159	1
+MD-2-related lipid-recognition domain [IPR003172]	0.7594310451453558	3.0506840808047655	0.0022832067260929	0.9975219174774238	0.0053827271728065	2	P17900	1
+Marvel domain [IPR008253]	0.7547928262214116	3.026111510472748	0.0024772092611513	0.9985126241395088	0.0057009704097003	2	O43760	1
+SUN coiled coil domain 2 [IPR040994]	0.7526283240569038	3.014618259495135	0.0025730287986236	0.998844133392559	0.0058276105231985	2	Q9UH99	1
+IMD/I-BAR domain [IPR013606]	0.7492269635126747	2.996523800181381	0.0027307692048703	0.9992368641244505	0.0060768013418806	2	Q9UQB8	1
+Prolyl 4-hydroxylase alpha subunit, Fe(2+) 2OG dioxygenase domain [IPR044862]	0.7998099162959476	2.9868466678947327	0.0028187105696844	0.999394564706198	0.0062168518889223	3	O15460	1
+Patatin-like phospholipase domain [IPR002641]	0.7399505256648387	2.9469650513391117	0.0032090947036524	0.9997833915231285	0.0068766315078267	2	Q9NP80	1
+TRAM/LAG1/CLN8 homology domain [IPR006634]	0.8928244735789389	2.940330229207669	0.0032786261510173	0.9998196359291388	0.00699706800522	5	Q96G23,Q15629,P27544	3
+KHDRBS, Qua1 domain [IPR032571]	0.7343846629560882	2.9170810454080716	0.003533239532059	0.99990776560343	0.0074316937272877	2	O75525	1
+Sam68, tyrosine-rich domain [IPR032335]	0.7343846629560882	2.9170810454080716	0.003533239532059	0.99990776560343	0.0074316937272877	2	O75525	1
+N-acetylgalactosaminyltransferase [IPR045885]	0.7788431797092285	2.881122065896156	0.0039626214311909	0.9999702459476772	0.0081556675015817	3	Q10472,Q8N4A0	2
+EF-hand domain [IPR002048]	0.5135663143744675	2.86988479183334	0.0041062137950094	0.99997962092729	0.0083784435947666	48	P41208,Q14257,O75340,P80303,Q8NF37,Q02818,O43852,Q9NWM8,P0DP25,O75071,Q66K14,Q9Y680,O95302,Q6NUK1,Q9BRK5,Q6KCM7,Q7L5N7,P43304,P14649,O95202	20
+Ion transporter-like, CBS domain [IPR044751]	0.7251082251082216	2.8670240779234812	0.0041435148712931	0.9999815292640116	0.0084074558264466	2	Q6P4Q7	1
+CNNM, transmembrane domain [IPR002550]	0.7251082251082216	2.8670240779234812	0.0041435148712931	0.9999815292640116	0.0084074558264466	2	Q6P4Q7	1
+Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase, N-terminal [IPR018955]	0.7192331478045726	2.8351582230442407	0.0045802994803569	0.999994160735033	0.0090536793192297	2	Q15118	1
+Histidine kinase domain [IPR005467]	0.7192331478045726	2.8351582230442407	0.0045802994803569	0.999994160735033	0.0090536793192297	2	Q15118	1
+Fzo/mitofusin HR2 domain [IPR006884]	0.7179962894248794	2.82843340468068	0.0046776432083723	0.9999954828136476	0.0091907286092646	2	Q8IWA4	1
+Acyl-CoA oxidase, C-terminal [IPR002655]	0.717687074829958	2.8267513163045987	0.0047022829727223	0.9999957670245708	0.0092322309673868	2	Q15067	1
+Class II aldolase/adducin N-terminal [IPR001303]	0.7012987012986975	2.737091496401423	0.0061985050427619	0.9999999184225752	0.011481858632108	2	P35611	1
+ATP-dependent RNA helicase eIF4A, DEAD-box helicase domain [IPR044728]	0.6985157699443374	2.721766303855588	0.0064934043678264	0.9999999625690468	0.0118291574533391	2	P60842	1
+XPC-binding domain [IPR015360]	0.6978973407544857	2.718356738845515	0.0065607059944379	0.9999999686670415	0.0119342603722711	2	P54725	1
+RAD23A/RAD23B, UBA1 domain [IPR041811]	0.6978973407544857	2.718356738845515	0.0065607059944379	0.9999999686670415	0.0119342603722711	2	P54725	1
+EF hand associated, type-2 [IPR013567]	0.694805194805191	2.701287231661087	0.0069071658662895	0.999999987458444	0.0124272175455861	2	Q8IXI2	1
+EF hand associated, type-1 [IPR013566]	0.694805194805191	2.701287231661087	0.0069071658662895	0.999999987458444	0.0124272175455861	2	Q8IXI2	1
+MIRO domain [IPR020860]	0.694805194805191	2.701287231661087	0.0069071658662895	0.999999987458444	0.0124272175455861	2	Q8IXI2	1
+CARG-binding factor, N-terminal [IPR012956]	0.69418676561534	2.697868987759678	0.0069784898709757	0.9999999896134352	0.0125383544909727	2	Q99729	1
+Vacuolar protein sorting-associated protein 13, SHR-binding domain [IPR009543]	0.7417366181462257	2.6905201222620168	0.0071340732530358	0.9999999931159684	0.0127394165232782	3	Q5THJ4	1
+Vacuolar protein sorting-associated protein 13-like, N-terminal domain [IPR026854]	0.7417366181462257	2.6905201222620168	0.0071340732530358	0.9999999931159684	0.0127394165232782	3	Q5THJ4	1
+Vacuolar protein sorting-associated protein 13, second N-terminal domain [IPR031646]	0.7417366181462257	2.6905201222620168	0.0071340732530358	0.9999999931159684	0.0127394165232782	3	Q5THJ4	1
+VPS13, repeated coiled region [IPR031642]	0.7417366181462257	2.6905201222620168	0.0071340732530358	0.9999999931159684	0.0127394165232782	3	Q5THJ4	1
+Vacuolar protein sorting-associated protein 13, C-terminal [IPR031645]	0.7417366181462257	2.6905201222620168	0.0071340732530358	0.9999999931159684	0.0127394165232782	3	Q5THJ4	1
+Man1/Src1, C-terminal [IPR018996]	0.6920222634508308	2.685893713844081	0.0072336095239426	0.9999999947088736	0.0128996093752374	2	Q8NC56	1
+Tim10-like [IPR004217]	0.7274976801731913	2.6161664701673293	0.008892319209043	0.9999999999343536	0.0151573622881416	3	Q9Y5J7,Q9Y5J9	2
+ERAP1-like C-terminal domain [IPR024571]	0.7735195638777468	2.602851995063516	0.0092451855744646	0.9999999999742218	0.0156571691180449	4	Q9NZ08,Q9UIQ6	2
+Glycoside hydrolase family 2, catalytic domain [IPR006103]	0.6768707482993457	2.6015666518568223	0.0092799030581161	0.9999999999764873	0.0157058320616084	2	P08236	1
+NOPS [IPR012975]	0.718836993504487	2.570606466320488	0.0101520616390151	0.9999999999976704	0.0169093666258977	3	Q8WXF1,P23246	2
+Flavoprotein pyridine nucleotide cytochrome reductase [IPR001709]	0.7167238982763424	2.559451689245143	0.0104837426215405	0.9999999999990336	0.0173626652249487	3	P16435	1
+Zinc finger, CHHC-type [IPR012996]	0.716053201360948	2.55590797539873	0.0105911124322057	0.999999999999273	0.0175183806770889	3	P55795,P31943	2
+Lysophosphatidylcholine acyltransferase LPCAT1-like [IPR045252]	0.7145066501701057	2.5477307166561434	0.0108426130064724	0.9999999999996272	0.0179118056274325	3	Q8NF37,Q7L5N7	2
+v-SNARE, coiled-coil homology domain [IPR042855]	0.713044240878264	2.5399908305063676	0.0110855375180995	0.9999999999998044	0.0182442231880949	3	O15498	1
+Longin domain [IPR010908]	0.713044240878264	2.5399908305063676	0.0110855375180995	0.9999999999998044	0.0182442231880949	3	O15498	1
+L27 domain [IPR004172]	0.7555693069307091	2.5134644490503635	0.0119551826718051	0.9999999999999806	0.0191941006198706	4	Q9NZW5,O14936,Q14168	3
+L27 domain, C-terminal [IPR014775]	0.7555693069307091	2.5134644490503635	0.0119551826718051	0.9999999999999806	0.0191941006198706	4	Q9NZW5,O14936,Q14168	3
+Choline/carnitine acyltransferase domain [IPR039551]	0.7046593539034554	2.495471850961643	0.0125789735251351	0.9999999999999964	0.0200113924364511	3	P50416	1
+MHC class I, alpha chain, C-terminal [IPR010579]	0.6974945870708186	2.4572394373648576	0.0140009335631343	1.0	0.0219155936811137	3	P04439,P10321	2
+MHC class I alpha chain, alpha1 alpha2 domains [IPR001039]	0.6974945870708186	2.4572394373648576	0.0140009335631343	1.0	0.0219155936811137	3	P04439,P10321	2
+Intermediate filament head, DNA-binding domain [IPR006821]	0.7422648514851636	2.4465787390495386	0.0144219292108218	1.0	0.02249409636269	4	P08670,Q16352,P07196	3
+Ribosomal S6 kinase, N-terminal catalytic domain [IPR041906]	0.6440940012368535	2.4161095496264986	0.01568734079383	1.0	0.023872040338437	2	P51812	1
+BTB/Kelch-associated [IPR011705]	0.6391465677179914	2.387751142260359	0.0169518161452939	1.0	0.0255152049205255	2	Q14145	1
+Bicarbonate transporter, C-terminal [IPR011531]	0.6376004947433711	2.3788693813020663	0.017365828266215	1.0	0.0258566643215056	2	Q9Y6M7	1
+Band 3 cytoplasmic domain [IPR013769]	0.6376004947433711	2.3788693813020663	0.017365828266215	1.0	0.0258566643215056	2	Q9Y6M7	1
+Ribosomal protein L10e/L16 [IPR016180]	0.6283240568954804	2.325380873208701	0.0200516033004631	1.0	0.0289046999800746	2	Q9NX20	1
+Gamma tubulin complex component, C-terminal [IPR040457]	0.6162646876932538	2.255337630866612	0.0241121443059606	1.0	0.0336135840696477	2	Q9BSJ2	1
+Gamma tubulin complex component protein, N-terminal [IPR041470]	0.6162646876932538	2.255337630866612	0.0241121443059606	1.0	0.0336135840696477	2	Q9BSJ2	1
+Cation-transporting P-type ATPase, C-terminal [IPR006068]	0.7434663182322477	2.237309680972541	0.0252661069284307	1.0	0.0350223739925299	5	P05023,P98194,P16615	3
+Cation-transporting P-type ATPase, N-terminal [IPR004014]	0.7434663182322477	2.237309680972541	0.0252661069284307	1.0	0.0350223739925299	5	P05023,P98194,P16615	3
+Glycosyltransferase 2-like [IPR001173]	0.7433747814871066	2.23686005291557	0.0252954881289313	1.0	0.0350223739925299	5	Q10472,Q8N4A0,Q10471	3
+P-type ATPase, haloacid dehalogenase domain [IPR044492]	0.749740756068274	2.23081852030307	0.0256931526503674	1.0	0.0354784459269934	8	P98194,P35670,Q9HD20,P05023,Q9NQ11,P16615	6
+Immunoglobulin C1-set [IPR003597]	0.6977103960396233	2.218616319093063	0.0265128383644432	1.0	0.0363996865620625	4	P55899,P04439,P10321	3
+MHC class I-like antigen recognition-like [IPR011161]	0.6977103960396233	2.218616319093063	0.0265128383644432	1.0	0.0363996865620625	4	P55899,P04439,P10321	3
+KASH domain [IPR012315]	0.6097711811997472	2.217383883964388	0.0265968700503438	1.0	0.0364641641795272	2	Q8NF91	1
+Zinc finger C2H2 AKAP95-type [IPR034736]	0.6486235694401379	2.1917012146830377	0.0284010879809752	1.0	0.0386684937500311	3	O43823,Q9ULX6	2
+FAD dependent oxidoreductase [IPR006076]	0.6884604435282528	2.170517701501154	0.0299676491215197	1.0	0.0402997330655682	4	Q96CU9,P43304	2
+BTB/POZ domain [IPR000210]	0.6393442622950849	2.1403419588679045	0.0323271414113135	1.0	0.0427715454660776	3	Q96CX2,Q14145	2
+Sulfatase, N-terminal [IPR000917]	0.6387256418187335	2.1369073536268286	0.0326055277814083	1.0	0.0430314280674695	3	P15586,P15289	2
+Mst1 SARAH domain [IPR024205]	0.5837971552257206	2.0639065790552857	0.0390265748459848	1.0	0.0495620507840881	2	Q13188	1
+SARAH domain [IPR011524]	0.5837971552257206	2.0639065790552857	0.0390265748459848	1.0	0.0495620507840881	2	Q13188	1
+Peptidase M41 [IPR000642]	0.5834879406307986	2.0620635313961233	0.0392016878067948	1.0	0.0497363124663299	2	Q96TA2	1
+GTPase effector domain [IPR020850]	0.6210723884909621	2.038337059743792	0.041516236054873	1.0	0.0521685589487993	3	P50570	1
+Dynamin GTPase effector [IPR003130]	0.6210723884909621	2.038337059743792	0.041516236054873	1.0	0.0521685589487993	3	P50570	1
+Dynamin stalk domain [IPR000375]	0.6210723884909621	2.038337059743792	0.041516236054873	1.0	0.0521685589487993	3	P50570	1
+Alcohol dehydrogenase, N-terminal [IPR013154]	0.6991631449843241	2.0169587298791924	0.043699820326456	1.0	0.05462477540807	5	Q8N4Q0	1
+GOLD domain [IPR009038]	0.73732738979987	2.005634665859489	0.0448952405031282	1.0	0.0558530835643182	6	P49755,Q9BVK6,Q15363,Q9Y3A6	4
+Agenet-like domain [IPR008395]	0.5680272108843476	1.969438638382294	0.048902742439665	1.0	0.0597902649763022	2	P51114	1
+Synaptic functional regulator FMRP, KH0 domain [IPR040472]	0.5680272108843476	1.969438638382294	0.048902742439665	1.0	0.0597902649763022	2	P51114	1
+Fragile X-related 1 protein, C-terminal core [IPR022034]	0.5680272108843476	1.969438638382294	0.048902742439665	1.0	0.0597902649763022	2	P51114	1
+Fxr1, tudor domain [IPR041560]	0.5680272108843476	1.969438638382294	0.048902742439665	1.0	0.0597902649763022	2	P51114	1
+Fragile X-related 1 protein, C-terminal region 1 [IPR032172]	0.5680272108843476	1.969438638382294	0.048902742439665	1.0	0.0597902649763022	2	P51114	1
+Dynamin, GTPase domain [IPR001401]	0.6395798899891699	1.9119732100983635	0.0558796303254474	1.0	0.067111457835781	4	P50570,O60313	2
+Tubulin/FtsZ, GTPase domain [IPR003008]	0.6758232737754	1.89869357655522	0.057604776616482	1.0	0.068952365991001	5	P07437,Q13885,P04350	3
+Tubulin/FtsZ, 2-layer sandwich domain [IPR018316]	0.6758232737754	1.89869357655522	0.057604776616482	1.0	0.068952365991001	5	P07437,Q13885,P04350	3
+LEM domain [IPR003887]	0.713626467820696	1.8912448884340016	0.0585916617425221	1.0	0.0697519782649073	6	P42167,P50402	2
+Phospholipid/glycerol acyltransferase [IPR002123]	0.6655693384928625	1.88781971548332	0.0590501574775748	1.0	0.0701705130731706	9	Q7L5N7,Q9HCL2,Q9NUQ2,Q92604,Q8NF37	5
+Follistatin-like, N-terminal [IPR003645]	0.552875695732832	1.877780075566364	0.06041125702096	1.0	0.0714966409738594	2	Q12841	1
+Cytochrome b5-like heme/steroid binding domain [IPR001199]	0.6953956883555582	1.8767536380627496	0.0605518673842027	1.0	0.0715984918394288	7	O43169,O95864,O15173,O00264,Q8WUJ1	5
+FAD-binding domain, ferredoxin reductase-type [IPR017927]	0.6292463772783323	1.8563927690496376	0.0633975946548583	1.0	0.0742277814313127	4	P16435	1
+Oxidoreductase FAD/NAD(P)-binding [IPR001433]	0.6292463772783323	1.8563927690496376	0.0633975946548583	1.0	0.0742277814313127	4	P16435	1
+Lamin tail domain [IPR001322]	0.5873801422827041	1.8472620612933783	0.0647091686114837	1.0	0.0755275978680057	3	P20700,P02545	2
+EB1, C-terminal [IPR004953]	0.547619047619041	1.8457795940345187	0.0649242146913349	1.0	0.0757449171398907	2	Q15555	1
+Zinc finger, CW-type [IPR011124]	0.5435992578849655	1.8212402465651996	0.0685703450790118	1.0	0.0793638253229303	2	Q8NB78	1
+Intermediate filament, rod domain [IPR039008]	0.6666579217976284	1.8092151116209136	0.0704175908358804	1.0	0.0812153672865492	8	P08670,P48681,Q16352,P07196	4
+Target SNARE coiled-coil homology domain [IPR000727]	0.6663323385130899	1.8075252811694775	0.070680416519407	1.0	0.0814469242157346	8	Q86Y82,O15400,Q9UNK0,Q13277	4
+ABC transporter type 1, transmembrane domain [IPR011527]	0.6796106109155966	1.7974507786269174	0.0722640855723308	1.0	0.0830530755811596	7	P08183,Q03518,O75027	3
+CD80-like, immunoglobulin C2-set [IPR013162]	0.5383426097711745	1.789062116544254	0.0736048123559307	1.0	0.084372328573938	2	P43121	1
+Armadillo repeat-containing domain [IPR006911]	0.5374149659863934	1.7833733544973849	0.074525547700911	1.0	0.085353212353792	2	Q96D09	1
+Ribosomal L28e/Mak16 [IPR029004]	0.536487322201601	1.7776815362049794	0.0754561738335202	1.0	0.0863813590549457	2	P46779	1
+FCH domain [IPR001060]	0.5303030303030234	1.739658729426783	0.0819189601825474	1.0	0.0933726749801072	2	Q15642	1
+F-BAR domain [IPR031160]	0.5303030303030234	1.739658729426783	0.0819189601825474	1.0	0.0933726749801072	2	Q15642	1
+Domain of unknown function DUF5600 [IPR040990]	0.5299938157080946	1.7377540909193527	0.0822541531782241	1.0	0.0936733848558951	2	Q9H223	1
+EH domain-containing protein, N-terminal [IPR031692]	0.5299938157080946	1.7377540909193527	0.0822541531782241	1.0	0.0936733848558951	2	Q9H223	1
+Band 7 domain [IPR001107]	0.651753641671494	1.7315718725325768	0.083349817850749	1.0	0.0948388694660668	8	Q99623,P35232,P27105,O75477,Q9UJZ1,O75955	6
+3-hydroxyacyl-CoA dehydrogenase, C-terminal [IPR006108]	0.566176074860063	1.7251041917454215	0.084508697271989	1.0	0.0959910559666686	3	P40939	1
+3-hydroxyacyl-CoA dehydrogenase, NAD binding [IPR006176]	0.566176074860063	1.7251041917454215	0.084508697271989	1.0	0.0959910559666686	3	P40939	1
+Fibronectin type II domain [IPR000562]	0.5644485141143031	1.7150898867744224	0.0863287482083707	1.0	0.0978889693507444	3	Q9UBV2	1
+Phosphoinositide 3-kinase, accessory (PIK) domain [IPR001263]	0.523809523809519	1.6995925683202646	0.0892075892089812	1.0	0.1008918232113639	2	P42356	1
+Ribosomal protein S4/S9, N-terminal [IPR001912]	0.5111317254174323	1.6209643946710668	0.1050252749913016	1.0	0.1181186298131045	2	Q9NV31	1
+Immunoglobulin V-set domain [IPR013106]	0.5800952142359705	1.5879120049227171	0.1123062384795132	1.0	0.12571593859647	4	P78310	1
+Extended PHD (ePHD) domain [IPR034732]	0.5052566481137837	1.5843541474387313	0.1131131501365954	1.0	0.1265652255364718	2	Q8IWS0	1
+Ricin B, lectin domain [IPR000772]	0.6131149355954377	1.573938818487917	0.1155015944759991	1.0	0.1291276343694624	5	Q10472,Q8N4A0,Q9UBG0	3
+Polyamine biosynthesis  domain [IPR030374]	0.5027829313543525	1.5689080563201898	0.116669364402258	1.0	0.1302113441989487	2	P19623	1
+Spermidine synthase, tetramerisation domain [IPR035246]	0.5027829313543525	1.5689080563201898	0.116669364402258	1.0	0.1302113441989487	2	P19623	1
+Heat shock chaperonin-binding [IPR006636]	0.6097065470703631	1.5560190091858224	0.119703572203982	1.0	0.1334275486350118	5	Q9NRR5,Q9UHD9,P54725	3
+Ribosomal protein S10 domain [IPR027486]	0.5003092145949214	1.55344395083493	0.1203171097885553	1.0	0.1340545047516799	2	P60866	1
+Legume-like lectin [IPR005052]	0.5362280889740909	1.5502760188349374	0.1210752806855621	1.0	0.1348129449443942	3	Q9H0V9	1
+RNA recognition motif domain, eukaryote [IPR003954]	0.5358583032178359	1.5182246113234024	0.1289577851565861	1.0	0.1427125573507751	14	Q9UHX1,Q14498,Q96I25,O95628	4
+Ubiquitin system component CUE [IPR003892]	0.5295391277451322	1.5108953613785447	0.1308151128880585	1.0	0.1446460283619013	3	Q9H1I8,Q9Y679	2
+Domain of unknown function DUF4217 [IPR025313]	0.4925788497216994	1.505006641235692	0.1323223693078423	1.0	0.1462510397612994	2	Q13206	1
+SAM domain [IPR041418]	0.4897959183673393	1.4875293516673338	0.136875056973782	1.0	0.1507750837415769	2	Q9NZI7	1
+CP2 transcription factor [IPR007604]	0.4897959183673393	1.4875293516673338	0.136875056973782	1.0	0.1507750837415769	2	Q9NZI7	1
+Zinc finger, MYND-type [IPR002893]	0.4888682745825528	1.4816990835228174	0.1384203810685158	1.0	0.1524133810003582	2	Q9ULU4	1
+Polyketide synthase, enoylreductase domain [IPR020843]	0.6304506617675052	1.4795060960145303	0.1390051033044237	1.0	0.1529930382281393	6	Q8N4Q0	1
+UBX domain [IPR001012]	0.5597137262401419	1.4747830061713536	0.1402708914229258	1.0	0.1543214962217855	4	Q96CS3	1
+Dynamin, N-terminal [IPR045063]	0.5993752472829333	1.454359094835364	0.1458467745027813	1.0	0.1598529365635912	8	O95140,O60313,Q8IWA4	3
+Dynamin-type guanine nucleotide-binding (G) domain [IPR030381]	0.5993752472829333	1.454359094835364	0.1458467745027813	1.0	0.1598529365635912	8	O95140,O60313,Q8IWA4	3
+Thioredoxin-like fold [IPR012336]	0.476808905380326	1.4057133705285676	0.1598092550254615	1.0	0.1741383538571342	2	Q6DKJ4	1
+Immunoglobulin-like domain [IPR007110]	0.5089060082255545	1.398115784464306	0.1620783006232866	1.0	0.1765375681062769	15	Q08722,P35613,P55899,P78310,P04439	5
+Glutathione S-transferase, N-terminal [IPR004045]	0.5831857795825223	1.3674815789031938	0.1714744073678056	1.0	0.1866170478194402	8	O43708,Q9H7Z7	2
+Cyclin-like [IPR013763]	0.4706246134817485	1.3666200822233412	0.1717444192293278	1.0	0.1866787165536171	2	P20248	1
+Cyclin, N-terminal [IPR006671]	0.4706246134817485	1.3666200822233412	0.1717444192293278	1.0	0.1866787165536171	2	P20248	1
+Cyclin, C-terminal domain [IPR004367]	0.4706246134817485	1.3666200822233412	0.1717444192293278	1.0	0.1866787165536171	2	P20248	1
+Chromo shadow domain [IPR008251]	0.5035570677389463	1.356963512991226	0.1747928042546069	1.0	0.1898349653158226	3	P83916,Q13185	2
+Chromo domain subgroup [IPR017984]	0.5035570677389463	1.356963512991226	0.1747928042546069	1.0	0.1898349653158226	3	P83916,Q13185	2
+SCP2 sterol-binding domain [IPR003033]	0.5032477575007773	1.355122946004718	0.1753783891058926	1.0	0.1903921717960993	3	P22307,Q6YN16	2
+Survival motor neuron [IPR010304]	0.4638218923933128	1.323532487422194	0.1856583598781762	1.0	0.2012193206772141	2	Q16637	1
+FKBP-type peptidyl-prolyl cis-trans isomerase domain [IPR001179]	0.5201849819690658	1.3219314261980843	0.1861909865582116	1.0	0.2017133057017357	12	Q9NWM8,Q9Y680	2
+RNA-binding S4 domain [IPR002942]	0.4948963810702177	1.305369164290341	0.1917671730617871	1.0	0.2074974564250582	3	Q9NV31,P46781	2
+Extended synaptotagmin, C2A domain [IPR037733]	0.4588744588744534	1.2921474988314905	0.1963060692605358	1.0	0.2117105307349657	2	A0FGR8	1
+Synaptotagmin-like mitochondrial-lipid-binding domain [IPR031468]	0.4588744588744534	1.2921474988314905	0.1963060692605358	1.0	0.2117105307349657	2	A0FGR8	1
+Extended synaptotagmin, C-terminal C2 domain [IPR037752]	0.4588744588744534	1.2921474988314905	0.1963060692605358	1.0	0.2117105307349657	2	A0FGR8	1
+Extended synaptotagmin, C2B domain [IPR037749]	0.4588744588744534	1.2921474988314905	0.1963060692605358	1.0	0.2117105307349657	2	A0FGR8	1
+Synaptotagmin, SMP domain [IPR039010]	0.4588744588744534	1.2921474988314905	0.1963060692605358	1.0	0.2117105307349657	2	A0FGR8	1
+Major sperm protein (MSP) domain [IPR000535]	0.4918032786885288	1.2869157112565273	0.1981236685077534	1.0	0.2134077266445846	3	O95292,Q9P0L0	2
+Peptidase M16, middle/third domain [IPR032632]	0.4452690166975797	1.2056790375414024	0.2279412707452741	1.0	0.2443225135591444	2	P14735	1
+AMP-binding enzyme, C-terminal domain [IPR025110]	0.538564745647147	1.1773549231595226	0.239053873625247	1.0	0.2557116618851969	5	Q9UKU0	1
+Guanylate kinase/L-type calcium channel beta subunit [IPR008145]	0.5381373142132493	1.1237310881395208	0.2611271236837278	1.0	0.2784153938545026	8	Q00013,Q9NZW5,O14936,Q14168	4
+Guanylate kinase-like domain [IPR008144]	0.5381373142132493	1.1237310881395208	0.2611271236837278	1.0	0.2784153938545026	8	Q00013,Q9NZW5,O14936,Q14168	4
+SKP1 component, POZ domain [IPR016073]	0.4245516388373445	1.0738272224018732	0.2829001265989339	1.0	0.3001668683598228	2	P63208	1
+NIPSNAP [IPR012577]	0.4553046705846002	1.0685949271000958	0.2852522353961804	1.0	0.3025402496626155	3	Q9UFN0,Q9BPW8	2
+Prolyl 4-hydroxylase, alpha subunit [IPR006620]	0.5489918503748396	1.0650178676384203	0.2868678442093073	1.0	0.3038854281878256	6	O15460	1
+Oxoglutarate/iron-dependent dioxygenase [IPR005123]	0.5489918503748396	1.0650178676384203	0.2868678442093073	1.0	0.3038854281878256	6	O15460	1
+Dual specificity protein phosphatase domain [IPR020422]	0.4535024365011706	1.057811812873369	0.2901412461793859	1.0	0.307105149685842	3	Q8WUK0	1
+Dual specificity phosphatase, catalytic domain [IPR000340]	0.4535024365011706	1.057811812873369	0.2901412461793859	1.0	0.307105149685842	3	Q8WUK0	1
+S100/CaBP-9k-type, calcium binding, subdomain [IPR013787]	0.4534488091555877	1.0574909835121094	0.2902875674671041	1.0	0.3071361808146507	3	Q99584,P60903	2
+Peptidase M16, C-terminal [IPR007863]	0.5285537196999375	1.0133397718597426	0.3108978966383116	1.0	0.3273593977840224	7	P22695,Q5JRX3,Q10713	3
+Peptidase M16, N-terminal [IPR011765]	0.5285537196999375	1.0133397718597426	0.3108978966383116	1.0	0.3273593977840224	7	P22695,Q5JRX3,Q10713	3
+Domain of unknown function DUF3517 [IPR021905]	0.4351995051036235	0.948504695793296	0.3428725833974058	1.0	0.3598722636618113	3	Q70CQ2,Q9UPU5	2
+Ubiquitin-associated domain [IPR015940]	0.4516587335118418	0.9332802155200924	0.3506753074435957	1.0	0.3677677515139588	13	Q9NRR5,P45974,P54725,Q8NBM4,Q9Y5A7,Q5THJ4,P54727,Q9UHD9	8
+Sorting nexin Vps5-like, C-terminal [IPR015404]	0.4588760182041249	0.9073022447966448	0.3642469874325751	1.0	0.3813914407700477	4	Q9Y5X3	1
+Major facilitator superfamily domain [IPR020846]	0.4784127576752613	0.8551931341629367	0.3924442365398712	1.0	0.409608795593305	5	Q7L0J3,Q9H2V7,P53985	3
+Putative RNA methylase domain [IPR000241]	0.3846629560915188	0.8216395051852787	0.4112820983934211	1.0	0.4287591375229271	2	Q7Z4G4	1
+CTP synthase GATase domain [IPR033828]	0.3651824366110006	0.7009222528928707	0.4833515362124323	1.0	0.5001173758603211	2	P17812	1
+CTP synthase, N-terminal [IPR017456]	0.3651824366110006	0.7009222528928707	0.4833515362124323	1.0	0.5001173758603211	2	P17812	1
+Condensin complex subunit 1, C-terminal [IPR032682]	0.3633271490414275	0.6895645632655893	0.490468058668271	1.0	0.5070809980323795	2	P42695	1
+Sulphate adenylyltransferase catalytic domain [IPR024951]	0.3630179344464987	0.6876743650821474	0.4916578665716944	1.0	0.5077112115463013	2	O43252	1
+ATP-sulfurylase PUA-like domain [IPR025980]	0.3630179344464987	0.6876743650821474	0.4916578665716944	1.0	0.5077112115463013	2	O43252	1
+Sulphate adenylyltransferase [IPR002650]	0.3630179344464987	0.6876743650821474	0.4916578665716944	1.0	0.5077112115463013	2	O43252	1
+Peptidase M1, membrane alanine aminopeptidase [IPR014782]	0.4733314078754184	0.6819918801225693	0.4952440852697659	1.0	0.5106110462816714	6	Q9NZ08,Q9UIQ6	2
+Aminopeptidase N-like , N-terminal domain [IPR045357]	0.4733314078754184	0.6819918801225693	0.4952440852697659	1.0	0.5106110462816714	6	Q9NZ08,Q9UIQ6	2
+Zinc finger, UBP-type [IPR001607]	0.386637797711108	0.6635703820152714	0.5069653189406327	1.0	0.5214670698350944	3	Q7Z569,P45974	2
+Rhodanese-like domain [IPR001763]	0.4047029702970491	0.6089698563362363	0.542544419303514	1.0	0.5574086499693637	4	P25325,Q99956,P40818	3
+U2A'/phosphoprotein 32 family A, C-terminal [IPR003603]	0.3982054455445746	0.5743651799507419	0.5657207104274415	1.0	0.5805382583549781	4	P39687,Q92688,Q15435	3
+SUN domain [IPR012919]	0.3682802224404458	0.5597923689866686	0.5756210692962398	1.0	0.5900059769241036	3	Q9UH99	1
+Small GTP-binding protein domain [IPR005225]	0.285719400496	0.4582832442030322	0.6467489605585692	1.0	0.6611043697298459	48	P40616,Q9Y6B6,Q15382,Q8IXI2,P20340,P62820,Q9BZG1,P61020,P51151,Q15286,Q13636,Q9NR31,Q9NP72,Q9H0U4,P20337,Q969Q5,P18085,P61026,P61019	19
+Cyclic nucleotide-binding domain [IPR000595]	0.4004952027236236	0.4555556052611528	0.6487095734033239	1.0	0.6628503815429059	5	P10644,Q9Y4G8,Q8IY17,Q6P4Q7	4
+Glutathione S-transferase, C-terminal-like [IPR010987]	0.3755671924466089	0.4356850212158014	0.6630652749030306	1.0	0.676728750630037	12	O43708,Q9H7Z7	2
+Rpn11/EIF3F, C-terminal [IPR024969]	0.3694306930693153	0.4261257277239687	0.6700162339870817	1.0	0.6835571761430584	4	Q7L5N1,P51665,O00303	3
+OCRE domain [IPR041591]	0.3427157438911278	0.4215424448077183	0.6733590240226188	1.0	0.6867006363867034	3	P98175,P52756	2
+ELMO domain [IPR006816]	0.3129251700680192	0.3962103423777363	0.6919498622139573	1.0	0.7053857818685972	2	Q8IZ81	1
+Zinc finger, RanBP2-type [IPR001876]	0.3828827948679416	0.3142413219600183	0.7533377606553424	1.0	0.7649948246500092	8	Q92804,P35637	2
+ABC transporter-like, ATP-binding domain [IPR003439]	0.3563578017306485	0.2857640784891153	0.775058822520297	1.0	0.7864435288425898	11	P08183,Q03518,O75027	3
+Tudor domain [IPR002999]	0.3739658110506641	0.273632773628994	0.7843668451852142	1.0	0.7949663971471765	8	Q14739	1
+Heat shock protein DnaJ, cysteine-rich domain [IPR001305]	0.3093102381688881	0.2569603578579704	0.7972093755808385	1.0	0.8076706333074879	3	P31689,Q96EY1	2
+CBS domain [IPR000644]	0.3684082888094504	0.2260975086298313	0.8211255822501409	1.0	0.8306183635478304	7	P51798,Q8NE01,P51790,Q6P4Q7	4
+Mu homology domain [IPR028565]	0.2973391089108905	0.1131234930276043	0.9099326497988928	1.0	0.9183287988166448	4	Q9BXS5,Q9Y2T2,P48444	3
+Glutathione S-transferase, C-terminal [IPR004046]	0.3183973098465485	0.1049506341578367	0.9164149805350584	1.0	0.92451549727307	11	O43708	1
+AP complex, mu/sigma subunit [IPR022775]	0.2974311358712567	0.0425660749642211	0.9660474392234316	1.0	0.9723445275926028	5	P61923,Q9Y2T2,P48444,P53680	4
+PDZ domain [IPR001478]	0.2744225661295113	0.0325501812417371	0.9740332983654438	1.0	0.9800066723684516	21	P57105,O14936,O43464,Q9NZW5,Q00013,Q5T2T1,Q14168	7
+Thioredoxin domain [IPR013766]	0.2604899974862566	0.0185562212420319	0.9851951272042492	1.0	0.9908571681651932	25	Q9Y320,O43819,Q9H1E5,Q9H3N1	4

interpro_family/advanced/idx2term.json

@@ -0,0 +1 @@
+{"0": "Mitochondrial carrier protein [IPR002067]", "1": "P-type ATPase [IPR001757]"}

interpro_family/basic/idx2term.json

@@ -0,0 +1 @@
+{"0": "Mitochondrial carrier protein [IPR002067]", "1": "P-type ATPase [IPR001757]", "2": "Short-chain dehydrogenase/reductase SDR [IPR002347]", "3": "Small GTPase [IPR001806]", "4": "Proteasome, subunit alpha/beta [IPR001353]"}