Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size Mitochondrial protein import 0.6803449059170105 4.020192694400069 5.8150558110314776e-05 0.0755568181491143 0.0785614040070366 38 O60220,O43615,Q5JRX3,Q9Y5J9,Q10713,Q13505,Q96B49,P62072,O96008,Q9NX63,Q8N4H5,O75431,Q9NS69,Q3ZCQ8,Q15388,P12236,P06576,P08574,Q9Y584,Q96DA6,O60830,Q9UJS0,Q9Y512,P21796,O14925,O94826 26 Mitochondrial biogenesis 0.6808057652543906 3.7353620442041895 0.0001874453168588 0.2237358057548866 0.1266193115381746 32 Q9NX63,P06576,Q6UXV4,O75947,Q9NVH1,Q5XKP0,O75964,Q9BUR5,Q9Y512,O75431,O00411,P03928,P00846,Q04837,Q13505,P24539,P56385 17 Sphingolipid metabolism 0.7141808008101348 3.543402562732269 0.0003949992438758 0.4135978140800687 0.1607901199928674 27 Q16880,P10619,Q13510,O43681,O95470,P51648,Q16739,P06280,Q8N5B7,Q96G23,O15269,P16278,P17900,P07602,Q9NZJ7,P04062,P06865,Q06136 18 Cristae formation 0.7567221890940279 3.493875747149708 0.000476062531437 0.474451931480379 0.1607901199928674 22 Q9NX63,P06576,Q6UXV4,O75947,Q9NVH1,Q5XKP0,O75964,Q9BUR5,Q9Y512,O75431,P03928,P36542,P00846,Q13505,P24539,P56385 16 Protein localization 0.6454927366843151 3.2728948794244013 0.0010645206036217 0.762819389523346 0.2396945559154912 79 P46379,Q9NR77,O00116,O60220,O43808,O43615,Q9Y5J9,Q10713,Q13505,Q96B49,P62072,P05067,O96008,Q8N4H5,Q15067,Q9NX63,Q9Y5Y5,O15254,P09601,O75431,P34913,Q9NS69,Q5T8D3,Q3ZCQ8,P50542,Q15388,P06576,O75381,P08574,P51648,P40855,Q9Y584,Q13190,P56589,O60830,P28288,O43681,Q8NBU5,P50402,Q9Y512,P21796,O14925,Q9Y3D6 43 Glycosphingolipid metabolism 0.7583690953010015 3.227072573670885 0.0012506373534122 0.8156037845288179 0.241373009208563 16 Q16880,P10619,Q13510,O43681,P07602,Q9NZJ7,P04062,P06280 8 Respiratory electron transport atp synthesis by chemiosmotic coupling and heat production by uncoupling proteins 0.6159476293547379 3.1355386280851323 0.0017153883587457 0.9016752640463234 0.289686209083187 69 O14949,Q9BQ95,O96000,O75947,P03886,Q9UDW1,P13073,O75489,P00846,Q9Y375,Q86Y39,P24539,P56385,O75306,O43676,P21912,P31930,O75880,P03928,P36542,P06576,Q8IUX1,P08574,P20674,O75964,O43674,Q9NPL8,O14548,O43819,O75438,Q9P0J0,P00403,P38117,Q9NX14,P14927,Q15526 36 Respiratory electron transport 0.5934798085285057 3.084510931821232 0.0020388711703251 0.9365388152875116 0.2922580910097878 57 O14949,Q9BQ95,O96000,Q9UDW1,P03886,P13073,O75489,Q9Y375,Q86Y39,O75306,O43676,P21912,O75880,Q8IUX1,P08574,P20674,O43674,Q9NPL8,O14548,O43819,O75438,Q9P0J0,P00403,P38117,Q9NX14,P14927,Q15526 27 Class i peroxisomal membrane protein import 0.8192867744976685 2.9193642643805293 0.0035074610502778 0.9913215258431995 0.3948816565771184 12 P28288,O75381,Q9NR77,Q9Y5Y5,P51648,P40855,O43808,Q5T8D3,Q9Y3D6,P56589 10 Slc mediated transmembrane transport 0.6188297292647649 2.695266700018367 0.0070332311235834 0.9999277564325264 0.4861021665942684 24 Q96QD8,Q9Y6M7,Q8TAD4,P35613,Q70HW3,Q8TB61,P36404,Q99808,Q9UBX3,Q9H936,P08195,O00400,Q8NEW0,P12236,P12235,P30825,P53985 17 Rab geranylgeranylation 0.6317920260846759 2.684886342779936 0.0072554474550639 0.999946607581502 0.4861021665942684 22 Q9NP72,P20337,O95716,Q15907,Q9NRW1,Q9H0U4,Q9BZG1,P61026,P20339,P62820,P61106,P20340,Q969Q5,P61020,P51151,P51149,P61019,P51148,Q9UL25 19 Insertion of tail anchored proteins into the endoplasmic reticulum membrane 0.7945883469499571 2.547681888512173 0.0108441305786604 0.9999995994530834 0.5593385507751655 10 O43681,P51648,P50402,P09601,Q13190,P05067 6 Ire1alpha activates chaperones 0.5892341944000793 2.5370690398020908 0.0111784906520573 0.9999997463181236 0.5593385507751655 25 O95070,O14773,P43307,O76024,Q9NWM8 5 Gpcr ligand binding 0.7881262915238131 2.515849806899753 0.0118745773957142 0.9999999020260436 0.5709153592199842 10 Q9BYT8,P07602,P63218,Q9NZJ7,P42892,P05067 6 Complex i biogenesis 0.5201353436659957 2.4562566503897667 0.0140392851445043 0.999999994937856 0.5729300793972575 32 Q9BQ95,O75306,O96000,O43676,P03886,Q8IUX1,O43674,O75489,O75438,Q9NX14,Q9P0J0,Q86Y39 12 Mitochondrial calcium ion transport 0.615650897724512 2.418646370636208 0.0155783766524142 0.9999999993866244 0.5729300793972575 18 Q9BPX6,Q9Y4W6,Q9H4I9,P35232,Q8IYU8,P45880,P21796,Q8NE86,Q9UJZ1,O95202,Q99623,O75439,Q10713,Q9Y277 14 Peptide ligand binding receptors 0.831236650714508 2.4160268277446044 0.0156909052092513 0.999999999474402 0.5729300793972575 7 Q9BYT8,P07602,Q9NZJ7,P42892,P05067 5 Class a 1 rhodopsin like receptors 0.831236650714508 2.4160268277446044 0.0156909052092513 0.999999999474402 0.5729300793972575 7 Q9BYT8,P07602,Q9NZJ7,P42892,P05067 5 Formation of atp by chemiosmotic coupling 0.7143432819480866 2.37086657615417 0.0177464360757957 0.9999999999688038 0.623731685862011 12 P06576,O75947,O75964,P03928,P00846,P24539,P56385 7 Regulation of insulin like growth factor igf transport and uptake by insulin like growth factor binding proteins igfbps 0.6322211032390762 2.306690482769079 0.0210720811997382 0.9999999999996808 0.6759088111571933 15 Q07065,Q9BTY2,O43852,O76024,P05067 5 Pink1 prkn mediated mitophagy 0.7448874211398075 2.196793174599213 0.0280352207609895 1.0 0.6759088111571933 9 Q8N4H5,O96008,P21796,Q9NS69,Q8IWA4,Q15388,Q96B49 7 Mitophagy 0.6780634000720117 2.172681938545396 0.0298042640760556 1.0 0.6759088111571933 12 Q8N4H5,O96008,P21796,Q9NS69,P67870,Q8IWA4,Q15388,Q96B49 8 Glycosaminoglycan metabolism 0.6309187168714541 2.155980979501823 0.0310851503988109 1.0 0.6759088111571933 14 P07686,O75330,P08236,Q7LGA3,P15586,P54802,Q8TB61,Q8NCH0,P16278,P06865 10 Vitamin d calciferol metabolism 0.923699364198449 2.1333482998545903 0.0328961647917989 1.0 0.6759088111571933 4 Q99538,P38435 2 Sphingolipid de novo biosynthesis 0.6919060181542832 2.1330866841408533 0.0329176159128825 1.0 0.6759088111571933 11 O95470,P51648,Q96G23,O15269,Q06136 5 Metabolism of porphyrins 0.697749149104412 2.0577303108231475 0.0396160290311313 1.0 0.6759088111571933 10 Q7KZN9,P09601 2 Heparan sulfate heparin hs gag metabolism 0.7906640913713738 2.0534989866913893 0.0400242079145636 1.0 0.6759088111571933 5 P54802,P08236 2 The citric acid tca cycle and respiratory electron transport 0.5310106154724982 2.03174482466356 0.0421794955107022 1.0 0.6921244490072027 101 O14949,Q9BQ95,Q9UDW1,O96000,P03886,O75947,O95563,P13073,O75489,P00846,Q9Y375,Q86Y39,P24539,P56385,Q15120,O75306,P21912,O43676,P31930,O75880,P03928,P36542,P53985,P06576,Q8IUX1,P20674,P08574,O75964,P35613,O43674,Q9NPL8,O14548,O43819,O75438,Q9P0J0,P00403,P38117,P21796,Q9NX14,P14927,Q15526 41 Amino acid transport across the plasma membrane 0.7820224376711907 2.014803360616296 0.0439252567955315 1.0 0.6921244490072027 5 Q96QD8 1 Signaling by pdgfr in disease 0.8931523948698012 2.0135361577341544 0.0440582550811394 1.0 0.6921244490072027 4 Q6UN15 1 G alpha i signalling events 0.536347168579418 1.975327088432915 0.0482310410804198 1.0 0.711296426491128 21 P63096,P52292,P04899,P07602,P63218,Q9NZJ7,P05067 7 Heme degradation 0.8794685418730446 1.959397965714546 0.0500661987288699 1.0 0.711296426491128 4 P09601 1 Transport of inorganic cations anions and amino acids oligopeptides 0.6514605670558647 1.9142757493282263 0.0555849313528544 1.0 0.7124615853344237 11 Q96QD8,Q9UBX3,P30825 3 Pre notch processing in golgi 0.8643645425418338 1.899314759901554 0.0575231033644432 1.0 0.7124615853344237 4 P16615,P20340,Q9UBV2 3 Synthesis of very long chain fatty acyl coas 0.7306733167082239 1.870027971187738 0.0614799336961311 1.0 0.7285911440655541 6 O95573,P33121,Q9P035,Q9NZ01,Q53GQ0 5 Abc transporters in lipid homeostasis 0.8768683274021363 1.84426181673056 0.0651449932981043 1.0 0.7297841713326259 3 P40855,P28288 2 Signaling by gpcr 0.4237659151517641 1.8173237829881952 0.0691675504001687 1.0 0.7297841713326259 35 P63096,P52292,Q9BYT8,P04899,Q9NRV9,P07602,P63218,Q9NZJ7,P42892,P05067 10 Keratan sulfate keratin metabolism 0.7346866096866115 1.800105143579589 0.071844037592331 1.0 0.7297841713326259 5 P07686,P16278,P15586,P06865 4 Processing of smdt1 0.5810793398073968 1.7310598626346734 0.0834410881394061 1.0 0.7805767872463618 13 Q9BPX6,Q9Y4W6,Q9H4I9,P35232,Q8NE86,Q99623,O75439,Q10713,Q8IYU8 9 Translation of sars cov 1 structural proteins 0.7124232292534459 1.6976017924791582 0.0895829442971329 1.0 0.7982104228279878 5 Q10472 1 Biosynthesis of specialized proresolving mediators spms 0.8386363123066329 1.6883393900406234 0.0913460979685738 1.0 0.7982104228279878 3 P09960 1 Tp53 regulates metabolic genes 0.418444716243773 1.6857999159723691 0.0918343439871387 1.0 0.7982104228279878 34 P20674,Q9Y3B8,O75880,P13073,O43819,P00403 6 Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane 0.709757834757829 1.6852687579426109 0.0919367305265868 1.0 0.7982104228279878 5 P12236,P12235,P36404,Q99808 4 Gamma carboxylation hypusine formation and arylsulfatase activation 0.6432752675546581 1.67944921377643 0.0930645287851006 1.0 0.7982104228279878 9 P38435,O60725 2 Unfolded protein response upr 0.4090828437582716 1.6297400792864214 0.1031564427730842 1.0 0.8197903187437459 38 O95070,O43731,O14773,P43307,O76024,Q9NWM8 6 Transmission across chemical synapses 0.402351591077873 1.5904525993689207 0.1117328220364475 1.0 0.8256223893560743 36 Q9UBI6,Q14012,P68371,Q14168,P07196,P04899,Q96CW1,P63218,P52292,Q96QD8,P04350,P21964,O75915,P63096 14 Hs gag degradation 0.8142897398231429 1.5882598080115538 0.1122276019208046 1.0 0.8256223893560743 3 P54802 1 Pre notch expression and processing 0.5903851473475867 1.5745432091349516 0.1153619203496341 1.0 0.8256223893560743 11 P16615,Q8NBL1,Q9UBV2,P20340 4 Miscellaneous transport and binding events 0.6858495913551838 1.5740951765319446 0.1154654475313599 1.0 0.8256223893560743 5 Q8N4V1 1 Aquaporin mediated transport 0.6824307832659914 1.5581211592762614 0.1192045297159141 1.0 0.8256223893560743 5 P63218,Q99797 2 G1 s specific transcription 0.6182320538576995 1.5478809132212883 0.1216509708122151 1.0 0.8256223893560743 9 P00374,Q9Y619 2 Heme biosynthesis 0.6607935903367126 1.5381036833060189 0.1240232655611608 1.0 0.8256223893560743 6 P36551,Q7KZN9 2 Regulation of insulin secretion 0.5787104823781622 1.5084543811395716 0.1314382738375765 1.0 0.8256223893560743 11 O95573,Q9UBI6,P04899,P63218,P63096 5 Mucopolysaccharidoses 0.7653969384122625 1.498047901364982 0.1341208055093332 1.0 0.8256223893560743 4 P54802,P08236,P15586 3 Transport of bile salts and organic acids metal ions and amine compounds 0.7646849412602402 1.4951208894364 0.1348828950267306 1.0 0.8256223893560743 4 P35613,Q8TAD4,P53985 3 Glutamate neurotransmitter release cycle 0.7907040426126244 1.4908493917306571 0.1360010408328911 1.0 0.8256223893560743 3 Q96QD8 1 Keratan sulfate degradation 0.7618369526521883 1.483408393097724 0.1379659388332998 1.0 0.8256223893560743 4 P06865,P15586,P16278 3 Adrenaline noradrenaline inhibits insulin secretion 0.7593449626201627 1.4731542494308607 0.1407094482010205 1.0 0.8256223893560743 4 P63218,P04899,P63096 3 Synthesis secretion and inactivation of glucagon like peptide 1 glp 1 0.7571314339214628 1.4640415902624202 0.1431825849627199 1.0 0.8256223893560743 4 P67812,Q15005 2 Incretin synthesis secretion and inactivation 0.7571314339214628 1.4640415902624202 0.1431825849627199 1.0 0.8256223893560743 4 P67812,Q15005 2 Diseases of carbohydrate metabolism 0.6121597369323452 1.4374503355362471 0.1505900750257949 1.0 0.8256223893560743 8 P54802,P08236,P10253 3 Fgfr2 alternative splicing 0.4781122110560012 1.4345233662835843 0.1514229659501054 1.0 0.8256223893560743 16 P52597,Q01085,P31943,P31483 4 Synthesis secretion and inactivation of glucose dependent insulinotropic polypeptide gip 0.776156583629914 1.4305991527905824 0.1525451304265521 1.0 0.8256223893560743 3 P67812,Q15005 2 Synthesis secretion and deacylation of ghrelin 0.776156583629914 1.4305991527905824 0.1525451304265521 1.0 0.8256223893560743 3 P67812,Q15005 2 G alpha s signalling events 0.6367061491430577 1.421532098533138 0.155162128890189 1.0 0.8256223893560743 6 P04899,P63096 2 Gaba b receptor activation 0.6521410730890804 1.4158626496098283 0.1568157224015027 1.0 0.8256223893560743 5 P04899,P63096 2 Adp signalling through p2y purinoceptor 12 0.6521410730890804 1.4158626496098283 0.1568157224015027 1.0 0.8256223893560743 5 P04899,P63096 2 G alpha z signalling events 0.6521410730890804 1.4158626496098283 0.1568157224015027 1.0 0.8256223893560743 5 P04899,P63096 2 Gaba receptor activation 0.6521410730890804 1.4158626496098283 0.1568157224015027 1.0 0.8256223893560743 5 P04899,P63096 2 Arachidonic acid metabolism 0.606785078240108 1.4097196195367052 0.1586224891771284 1.0 0.8256223893560743 8 P34913,Q15165,P09960,Q15185 4 Initiation of nuclear envelope ne reformation 0.4719076640704465 1.407722955017256 0.1592131218594785 1.0 0.8256223893560743 17 P50402,P42166,P20700,Q86XL3,P42167,Q8IXJ6 6 Adora2b mediated anti inflammatory cytokines production 0.6058245713798094 1.4047588241618212 0.1600930070372301 1.0 0.8256223893560743 8 P04899,P63096 2 Hyaluronan metabolism 0.6492556544648579 1.4022496779606093 0.160840701652138 1.0 0.8256223893560743 5 P07686,P06865,P08236 3 Hyaluronan uptake and degradation 0.6492556544648579 1.4022496779606093 0.160840701652138 1.0 0.8256223893560743 5 P07686,P06865,P08236 3 Transport of vitamins nucleosides and related molecules 0.5993685908460942 1.3713773933417952 0.1702573409371144 1.0 0.8289477947669446 8 Q8TB61,P36404,O00400,P12236,P12235,Q99808 6 Cobalamin cbl vitamin b12 transport and metabolism 0.7569991470196222 1.3511334013598764 0.1766527035862022 1.0 0.8392724145756147 3 Q96EY8 1 Defects in cobalamin b12 metabolism 0.7569991470196222 1.3511334013598764 0.1766527035862022 1.0 0.8392724145756147 3 Q96EY8 1 Rac2 gtpase cycle 0.4157649092712316 1.350649068712071 0.1768078744800414 1.0 0.8392724145756147 29 P50402,Q9Y512,Q86XL3,P42167,Q8TAA9,O15173,Q13505 7 Phospholipid metabolism 0.3817172450270323 1.326114038975816 0.1848019266187985 1.0 0.8409486234884509 40 Q8IV08,Q9NPH0,O95674,Q9NQZ5,Q10713,Q9NTJ5,Q92604,Q8NCC3,Q9UG56,Q9BZF1,P48739,Q53H12,Q6UWP7,P20339,P67870,P61106,Q96N66,Q9BVG9,Q9BTU6 19 Miro gtpase cycle 0.7230331078675685 1.323237331796714 0.1857564648063787 1.0 0.8409486234884509 4 Q8IWA4,Q8IXI2,Q8IXI1 3 Ras processing 0.6300380344476361 1.3113672807742964 0.1897337074972003 1.0 0.8409486234884509 5 O60725 1 N glycan trimming in the er and calnexin calreticulin cycle 0.4941099711097512 1.3012932479433037 0.193158097523463 1.0 0.8409486234884509 14 Q9UBV2,Q9BUN8 2 Negative regulators of ddx58 ifih1 signaling 0.5982419670910576 1.2963519999854691 0.1948542410567717 1.0 0.8409486234884509 7 Q86UT6 1 Noncanonical activation of notch3 0.7409252669039164 1.284416758453962 0.1989961723237074 1.0 0.8409486234884509 3 Q92542,P67809 2 Formyl peptide receptors bind formyl peptides and many other ligands 0.7402627417929413 1.2816670933842869 0.1999594531154329 1.0 0.8409486234884509 3 P05067 1 Peptide hormone metabolism 0.5231437825653144 1.2789999511613943 0.2008970730898633 1.0 0.8409486234884509 12 Q15005,Q8NEW0,Q9UPT5,P61009,Q8TAD4,P67812 6 Diseases associated with glycosaminoglycan metabolism 0.7112182349036905 1.2743158805335222 0.202551490667858 1.0 0.8409486234884509 4 Q8NCH0 1 Chondroitin sulfate dermatan sulfate metabolism 0.7112182349036905 1.2743158805335222 0.202551490667858 1.0 0.8409486234884509 4 Q8NCH0 1 Signal amplification 0.592669333971662 1.2682615039556804 0.2047045796151991 1.0 0.8409486234884509 7 P04899,P63096 2 Cytochrome p450 arranged by substrate type 0.7341196505466173 1.256175147764545 0.2090524751185607 1.0 0.8409486234884509 3 Q16850 1 Synthesis of pips at the golgi membrane 0.6177585073786297 1.2531387690214677 0.2101552089840481 1.0 0.8409486234884509 5 Q10713,Q9NTJ5 2 Neuronal system 0.3811060730303386 1.2378946128058963 0.2157551401303905 1.0 0.8409486234884509 46 O95197,Q9UBI6,Q14012,P68371,Q14168,P05091,P07196,P04899,Q14254,Q96CW1,P63218,P52292,Q96QD8,P04350,P21964,O75915,P63096 17 Depolymerisation of the nuclear lamina 0.5591787121885786 1.232796830089776 0.2176515743092308 1.0 0.8409486234884509 9 P50402,P42167,P20700 3 Signaling by notch3 0.5979091036593001 1.2320658159253768 0.21792449957672 1.0 0.8409486234884509 6 Q92542,P67809 2 Negative regulation of nmda receptor mediated neuronal transmission 0.6122642529088343 1.2270579462288154 0.2198008124000994 1.0 0.8409486234884509 5 Q14168,P07196 2 Attachment of gpi anchor to upar 0.6095355212841721 1.214100262656446 0.2247094397330353 1.0 0.8409486234884509 5 Q9H490,O43292 2 Metabolism of folate and pterines 0.5683203358418618 1.2100721660593343 0.2262512025143528 1.0 0.8443794878367145 8 Q9H2D1 1 Beta oxidation of pristanoyl coa 0.6941972232111118 1.2037914254610895 0.2286702046666122 1.0 0.8463930041221731 4 O15254,O14734,P22307 3 Selective autophagy 0.3807636433878886 1.1896532688802657 0.2341826997077494 1.0 0.8529861287074798 32 O96008,Q8N4H5,P08670,P04350,P21796,Q9NS69,P67870,Q8IWA4,P50542,Q15388,Q96B49 11 Interleukin 4 and interleukin 13 signaling 0.5219762483471084 1.1834239306841945 0.2366411777612302 1.0 0.8529861287074798 11 P09601,P08670 2 Integrin cell surface interactions 0.6878380481038577 1.1774438547523212 0.239018394608617 1.0 0.8547519427751857 4 P35613,Q08722 2 Metabolism of steroid hormones 0.5839709352417938 1.163653114466504 0.2445646171702684 1.0 0.8578181584539761 6 P30536,Q53GQ0 2 Cell surface interactions at the vascular wall 0.4714288325231944 1.154504301188774 0.2482934761905166 1.0 0.8645476451891444 14 Q92896,Q08722,P35613,P14174,P08195,Q9BX67,P62993,Q9UPY5,P53985 9 Neurotransmitter release cycle 0.680703398947118 1.1478930687841238 0.2510127098982522 1.0 0.8650289393561398 4 Q96QD8 1 G protein mediated events 0.5415567426028394 1.1379146914392084 0.255156105994256 1.0 0.8673387054140688 9 P52292,P63096 2 Synthesis of pg 0.6769201517339706 1.132229948489466 0.2575377722747127 1.0 0.867664664197349 4 Q8IV08 1 Class b 2 secretin family receptors 0.7026370596829379 1.1257809653949828 0.2602582429861257 1.0 0.8724786259907095 3 P63218 1 Adenylate cyclase inhibitory pathway 0.7005349041754619 1.1170990170528152 0.2639519907484833 1.0 0.8742364337441569 3 P63096 1 Notch3 activation and transmission of signal to the nucleus 0.6731774842812988 1.1167407928687396 0.2641051705821393 1.0 0.8742364337441569 4 Q92542,P67809 2 Ddx58 ifih1 mediated induction of interferon alpha beta 0.4803788526727898 1.1123717908180124 0.2659783282430419 1.0 0.8742364337441569 13 P05067,Q86UT6 2 Synthesis of bile acids and bile salts via 7alpha hydroxycholesterol 0.6939501779359454 1.0899329213331914 0.2757426933998819 1.0 0.8742364337441569 3 O14734,P22307 2 Phase i functionalization of compounds 0.4765388841039619 1.0884507586464949 0.2763961635187071 1.0 0.8742364337441569 13 Q16850,O43169,P07099,Q15185 4 Egr2 and sox10 mediated initiation of schwann cell myelination 0.5764171056475791 1.0568045575891256 0.2906007938694741 1.0 0.8977169238407816 5 Q9NR77 1 Organelle biogenesis and maintenance 0.4099856178046056 1.0528133943833655 0.2924265248659929 1.0 0.8977169238407816 84 O75947,Q5XKP0,O94927,O00411,P00846,Q10713,Q13505,P24539,P56385,Q9NX63,Q9BUR5,O75431,P03928,Q04837,O75935,P06576,Q9NVH1,O75964,O95684,O43924,Q6UXV4,A6NIH7,Q9Y512 23 Glucagon signaling in metabolic regulation 0.6464038323441514 1.006218768168199 0.3143103458767116 1.0 0.9097990445888864 4 P63218 1 Vasopressin regulates renal water homeostasis via aquaporins 0.6464038323441514 1.006218768168199 0.3143103458767116 1.0 0.9097990445888864 4 P63218 1 Cholesterol biosynthesis 0.433281927909529 1.00620671997766 0.3143161402718224 1.0 0.9097990445888864 15 Q16850,Q9H2C2,Q15392,Q14534,Q15800 5 Rhog gtpase cycle 0.3475250455989456 0.981718600328452 0.3262384993223144 1.0 0.9097990445888864 34 P50402,Q96JJ3,P42167,Q13190,Q86XL3,O75489,Q8TAA9,O15173 8 Diseases associated with n glycosylation of proteins 0.6404216888760966 0.981622246577951 0.3262859835001381 1.0 0.9097990445888864 4 Q9BT22 1 Carboxyterminal post translational modifications of tubulin 0.543060707596599 0.9626941615671398 0.3357010275349403 1.0 0.9097990445888864 6 P68371,Q14166,Q9BVA1,P04350 4 Response to elevated platelet cytosolic ca2 0.3713890914042066 0.9555269469175016 0.339311284872863 1.0 0.9097990445888864 29 Q6UXV4,P05067,Q96JJ7,P07602,Q9NZJ7,Q9NUQ9,Q06481,O43852 8 Fatty acid metabolism 0.3596357480404867 0.9400189329985316 0.347207849222386 1.0 0.9097990445888864 52 Q9UMR5,O00767,O43808,Q9P035,P50897,Q8IVS2,Q15067,Q16836,O15254,P23786,P34913,Q5T8D3,Q53GQ0,P51648,Q15185,Q15165,Q9H7Z7,P22033,P49748,P09960,P33121,Q9NZ01,O95864 23 Activation of kainate receptors upon glutamate binding 0.6565836298932424 0.9369489432485296 0.3487848215688602 1.0 0.9097990445888864 3 P63218,Q9UBI6 2 Peroxisomal lipid metabolism 0.4653202016300352 0.932931870204506 0.3508551459887563 1.0 0.9097990445888864 12 Q15067,P51648,O15254,O14734,O43808,Q5T8D3,P22307 7 Thromboxane signalling through tp receptor 0.6551601423487585 0.9311730757261704 0.3517640428484956 1.0 0.9104084710504168 3 P63218,Q9UBI6 2 Adp signalling through p2y purinoceptor 1 0.6489749172859404 0.906132330964838 0.3648658145214432 1.0 0.9173236219455684 3 P63218 1 Nuclear signaling by erbb4 0.6201260581917429 0.8985752276312243 0.3688789586002641 1.0 0.922871415646651 4 Q92542 1 Glycerophospholipid biosynthesis 0.3649329600613655 0.8978978219280733 0.3692400259755153 1.0 0.922871415646651 29 Q6UWP7,Q92604,Q96N66,Q9BVG9,Q8IV08,Q8NCC3,Q9UG56,Q9NPH0,Q9BZF1,P67870,O95674,P48739,Q9NQZ5,Q53H12 14 Traf6 mediated nf kb activation 0.615156566461204 0.8783564093611024 0.3797503323437512 1.0 0.922871415646651 4 P05067 1 Ptk6 regulates proteins involved in rna processing 0.8427605834222722 0.8781025984237569 0.379888042996491 1.0 0.922871415646651 2 Q07666 1 Pyruvate metabolism 0.41326674776843 0.8710052256569645 0.3837512998184276 1.0 0.9241497434130048 15 Q15120,P21796 2 Activation of ampk downstream of nmdars 0.5239769580443476 0.8693638772299909 0.3846481344051877 1.0 0.9244687526864652 6 P68371,Q9BVA1,P04350,Q9BUF5 4 Vitamin b5 pantothenate metabolism 0.6094695621217631 0.855285037808133 0.3923933686237326 1.0 0.929636459995828 4 Q9NRN7,Q9NVE7,Q13057 3 Basigin interactions 0.5072492268489674 0.8369338225171423 0.4026297674192409 1.0 0.9427258505778068 7 P35613,P08195,Q9UPY5,P53985 4 Ra biosynthesis pathway 0.5288424554202997 0.8325333173911241 0.4051079802608108 1.0 0.945251953941892 5 Q8NBN7,Q9HBH5 2 Rab gefs exchange gtp for gdp on rabs 0.3680589484375977 0.8203841807025739 0.4119971307337713 1.0 0.949035939878538 26 P20339,Q9NRW1,P61020,Q9H0U4,Q9NP72,Q14C86,P51151,P51148,P62820,P51149,P61106,P20340,P61026,Q9UL25 14 Acyl chain remodeling of cl 0.6265774297563687 0.8163398571531313 0.4143057844100082 1.0 0.949035939878538 3 Q6UWP7 1 Alpha linolenic omega3 and linoleic omega6 acid metabolism 0.5024696477852568 0.8130239051960346 0.4162043524872523 1.0 0.949035939878538 7 Q15067,P33121,O14734,O95864,P22307 5 Gap junction assembly 0.5245218835111537 0.8123963188142433 0.4165642578445396 1.0 0.949035939878538 5 P68371,Q9BVA1,P04350 3 Transport of connexons to the plasma membrane 0.5245218835111537 0.8123963188142433 0.4165642578445396 1.0 0.949035939878538 5 P68371,Q9BVA1,P04350 3 Long term potentiation 0.5961956909244253 0.8017499130245371 0.4226976369838517 1.0 0.9527876963924587 4 P07196 1 Ras activation upon ca2 influx through nmda receptor 0.5961956909244253 0.8017499130245371 0.4226976369838517 1.0 0.9527876963924587 4 P07196 1 Unblocking of nmda receptors glutamate binding and activation 0.5961956909244253 0.8017499130245371 0.4226976369838517 1.0 0.9527876963924587 4 P07196 1 Cargo concentration in the er 0.3864709472536931 0.7876184126551807 0.4309199412677671 1.0 0.9527876963924587 16 Q15363,O75396,P49755,O14653,Q13190,Q96PC5 6 Pi metabolism 0.4401329376327537 0.7832260327117786 0.4334943902248476 1.0 0.9527876963924587 12 P20339,Q9BTU6,P48739,Q10713,Q9NTJ5 5 The nlrp3 inflammasome 0.5908160652085129 0.7801951744903246 0.4352760022479427 1.0 0.9527876963924587 4 P09601 1 Purinergic signaling in leishmaniasis infection 0.5908160652085129 0.7801951744903246 0.4352760022479427 1.0 0.9527876963924587 4 P09601 1 Inflammasomes 0.5908160652085129 0.7801951744903246 0.4352760022479427 1.0 0.9527876963924587 4 P09601 1 Translation of sars cov 2 structural proteins 0.3995510777966119 0.779002488924618 0.43597824860344 1.0 0.9527876963924587 15 Q9H0U3,Q10472,P27824 3 Calnexin calreticulin cycle 0.4940607343780374 0.7711089650062124 0.4406423471914817 1.0 0.9527876963924587 7 Q9UBV2 1 Collagen biosynthesis and modifying enzymes 0.4491654725656148 0.7646942117944099 0.4444536536998318 1.0 0.9527876963924587 11 O75718,Q32P28,P13674 3 Assembly and cell surface presentation of nmda receptors 0.4714383239530895 0.7617968499408667 0.4461812607593776 1.0 0.9527876963924587 9 Q92796,P68371,Q14168,P04350,P07196,Q9BVA1 6 Ca2 pathway 0.5861291296457966 0.7614903585256694 0.4463642354611523 1.0 0.9527876963924587 4 P63218 1 Trna modification in the nucleus and cytosol 0.4601420285902519 0.7609254894092825 0.4467015729709436 1.0 0.9527876963924587 10 Q08J23,O75648 2 Deadenylation of mrna 0.4331943633153503 0.7423561287632813 0.4578715928119643 1.0 0.9527876963924587 12 P23588,Q9HBH5,Q92600 3 Tp53 regulates transcription of cell cycle genes 0.4201175112472274 0.7390665898526774 0.4598665631681009 1.0 0.9527876963924587 13 Q9Y3B8 1 Glucagon like peptide 1 glp1 regulates insulin secretion 0.5082952096986214 0.7373109599092066 0.460933268735483 1.0 0.9527876963924587 5 P63218 1 Metabolism of steroids 0.3242347455150917 0.7371138673378843 0.4610531067676069 1.0 0.9527876963924587 40 P30536,Q99538,Q14849,O00767,Q16850,Q15392,P38435,Q14534,P04062,Q15800,Q53GQ0 11 Rhoa gtpase cycle 0.3197595155948995 0.7314618847753093 0.4644970774406836 1.0 0.9527876963924587 37 Q8NBN3,Q96HY6,P28288,P30519,P51572,P42167,Q13190,Q5T8D3,Q8TAA9,O15173 10 Transcriptional activation of mitochondrial biogenesis 0.4637363630703458 0.7211504112288042 0.4708169778856257 1.0 0.9527876963924587 9 P06576,Q04837,O00411 3 Conversion from apc c cdc20 to apc c cdh1 in late anaphase 0.5038288800061174 0.7168183233521718 0.4734862041020169 1.0 0.9527876963924587 5 Q96DE5 1 Golgi cisternae pericentriolar stack reorganization 0.438515572045793 0.704493206158676 0.4811256794946388 1.0 0.9527876963924587 11 P61019,P62820 2 Proton coupled monocarboxylate transport 0.7926004980434038 0.7004555653332446 0.4836428456803179 1.0 0.9527876963924587 2 P53985 1 Signaling by fgfr2 0.3644505510304255 0.6983651208166385 0.4849488833461914 1.0 0.9527876963924587 22 P52597,Q01085,P31943,P31483 4 Signaling by fgfr 0.3644505510304255 0.6983651208166385 0.4849488833461914 1.0 0.9527876963924587 22 P52597,Q01085,P31943,P31483 4 Opioid signalling 0.3725706314815764 0.6909008703525622 0.4896278391491995 1.0 0.9527876963924587 16 P52292,P04899,P63096 3 Activation of nmda receptors and postsynaptic events 0.3670186025530483 0.6755963721589123 0.499296945488713 1.0 0.9527876963924587 19 Q14012,P68371,Q14168,P07196,P52292,P04350 6 Peroxisomal protein import 0.3597992482297689 0.6474705996874672 0.5173274164957422 1.0 0.9527876963924587 21 Q15067,O75381,O15254,O00116,P34913,P50542 6 Linoleic acid la metabolism 0.7748132337246567 0.6400991797477078 0.5221081222455126 1.0 0.9527876963924587 2 P33121 1 Anti inflammatory response favouring leishmania parasite infection 0.4121113897448496 0.6197202452747936 0.5354419844464156 1.0 0.9527876963924587 12 P04899,P63096 2 Rhobtb1 gtpase cycle 0.3603767353821875 0.6072387751612041 0.5436924629413451 1.0 0.9527876963924587 16 P38159,P08670 2 Zinc efflux and compartmentalization by the slc30 family 0.7641408751334083 0.604697447928991 0.5453800441696368 1.0 0.9527876963924587 2 Q8TAD4 1 Zinc transporters 0.7641408751334083 0.604697447928991 0.5453800441696368 1.0 0.9527876963924587 2 Q8TAD4 1 Metal ion slc transporters 0.7641408751334083 0.604697447928991 0.5453800441696368 1.0 0.9527876963924587 2 Q8TAD4 1 Maturation of sars cov 2 spike protein 0.4200652224456713 0.6016565689201865 0.547402765446886 1.0 0.9527876963924587 11 Q9H0U3,P27824 2 Apc c cdc20 mediated degradation of cyclin b 0.4586600142551607 0.5976519198763005 0.550072213048419 1.0 0.9527876963924587 7 Q96DE5,Q9UJX4,Q9UJX3,P14635,Q9UJX6,P30260 6 Cs ds degradation 0.7612949128424105 0.5953679300392702 0.5515975575758936 1.0 0.9527876963924587 2 P06865 1 G protein activation 0.7588046958377845 0.5872443836091346 0.5570395877490666 1.0 0.9527876963924587 2 P63218 1 Inwardly rectifying k channels 0.7588046958377845 0.5872443836091346 0.5570395877490666 1.0 0.9527876963924587 2 P63218 1 Potassium channels 0.7588046958377845 0.5872443836091346 0.5570395877490666 1.0 0.9527876963924587 2 P63218 1 Glucagon type ligand receptors 0.7588046958377845 0.5872443836091346 0.5570395877490666 1.0 0.9527876963924587 2 P63218 1 Prostacyclin signalling through prostacyclin receptor 0.7588046958377845 0.5872443836091346 0.5570395877490666 1.0 0.9527876963924587 2 P63218 1 Presynaptic function of kainate receptors 0.7588046958377845 0.5872443836091346 0.5570395877490666 1.0 0.9527876963924587 2 P63218 1 Activated notch1 transmits signal to the nucleus 0.565135112871143 0.580524444454389 0.561561007292958 1.0 0.9527876963924587 3 Q92542 1 Alpha oxidation of phytanate 0.5385716113171071 0.5767622993555964 0.5641000407474333 1.0 0.9527876963924587 4 O43808 1 Amyloid fiber formation 0.4540793102834543 0.5756805968926433 0.5648310926575588 1.0 0.9527876963924587 7 Q9Y287,P05067 2 Tysnd1 cleaves peroxisomal proteins 0.4700870324196355 0.5652552992408064 0.5719001283168108 1.0 0.9527876963924587 5 Q15067,O00116 2 Transcriptional regulation by ventx 0.4420677361853742 0.5605603540104435 0.575097284929817 1.0 0.9527876963924587 8 Q96DE5,P04637,P35222,Q9UJX4,Q9UJX3,Q9UJX6,P30260 7 Signaling by ptk6 0.4224190664298184 0.5580368149916706 0.5768192451426755 1.0 0.9527876963924587 10 Q96JJ3,Q07666 2 Fatty acyl coa biosynthesis 0.389787758614759 0.5567898635452089 0.577671010252347 1.0 0.9527876963924587 13 Q9UMR5,O00767,P33121,P50897,Q9NZ01,Q53GQ0 6 Copi dependent golgi to er retrograde traffic 0.30571102231995 0.5369806152148751 0.5912810041832959 1.0 0.9527876963924587 41 Q9P2W9,Q9BVK6,P24390,Q9H0U4,O15260,Q12981,O43731,P62820,Q9Y3B3 9 Intrinsic pathway of fibrin clot formation 0.7420846673781619 0.5337118191295743 0.593540930684368 1.0 0.9527876963924587 2 P42785 1 Formation of fibrin clot clotting cascade 0.7420846673781619 0.5337118191295743 0.593540930684368 1.0 0.9527876963924587 2 P42785 1 Iron uptake and transport 0.3475504827030597 0.5295110806042469 0.5964509598458734 1.0 0.9527876963924587 18 P30519,P09601 2 Notch2 activation and transmission of signal to the nucleus 0.7406616862326623 0.529240917509267 0.5966383354167433 1.0 0.9527876963924587 2 Q92542 1 Regulated proteolysis of p75ntr 0.7406616862326623 0.529240917509267 0.5966383354167433 1.0 0.9527876963924587 2 Q92542 1 Nrif signals cell death from the nucleus 0.7406616862326623 0.529240917509267 0.5966383354167433 1.0 0.9527876963924587 2 Q92542 1 Signaling by notch2 0.7406616862326623 0.529240917509267 0.5966383354167433 1.0 0.9527876963924587 2 Q92542 1 Rab regulation of trafficking 0.3063284665059583 0.5247491676044925 0.5997575727028592 1.0 0.953691070092535 33 Q15907,Q8TC07,P20339,P61020,Q9H0U4,Q9NP72,Q14C86,P62820,P20340,P61026 10 Synthesis of substrates in n glycan biosythesis 0.4148263682534728 0.518369790707765 0.6042002877883266 1.0 0.953691070092535 10 P10619 1 Acyl chain remodelling of pg 0.7371042333689128 0.5181247944347163 0.6043712019609093 1.0 0.953691070092535 2 Q92604 1 Coenzyme a biosynthesis 0.736036997509788 0.5148072024469477 0.6066877518503127 1.0 0.953691070092535 2 Q9NVE7 1 Aflatoxin activation and detoxification 0.5448398576512415 0.5075124797601467 0.6117952821751005 1.0 0.953691070092535 3 Q99735,O14880 2 Extra nuclear estrogen signaling 0.380614730432847 0.5031937750887316 0.614828040942895 1.0 0.953691070092535 13 O43815,P04899,P63096 3 Free fatty acids regulate insulin secretion 0.7296335823550392 0.4950726155912842 0.6205488632201484 1.0 0.953691070092535 2 O95573 1 Signaling by erbb4 0.4424652654078978 0.4840053358359094 0.6283820823077566 1.0 0.953691070092535 6 Q92542,P16949,P62993,P61201,P49768 5 Neurotransmitter receptors and postsynaptic signal transmission 0.3123907984217777 0.4684869314163782 0.6394364144542366 1.0 0.9578705538862928 30 Q9UBI6,Q14012,Q14168,P07196,P04899,Q96CW1,P63218,P52292,P04350,P63096 10 Signaling by retinoic acid 0.3610168710293951 0.454163412403381 0.6497112148455011 1.0 0.960349946669882 14 Q15120,Q8NBN7 2 Tbc rabgaps 0.3481650559037204 0.4461128374817739 0.6555157401369591 1.0 0.9654892326586244 15 Q15907,Q8TC07,P20339,P61020,P20340 5 Metabolism of cofactors 0.4395866502373073 0.4350495955670716 0.663526428594424 1.0 0.9709008010413144 5 P00374 1 Sars cov 1 infection 0.3969514756490536 0.4271500084864059 0.6692700705756196 1.0 0.9720257455208068 10 Q10472 1 Trna modification in the mitochondrion 0.4368515916964473 0.4237832036063568 0.6717239287032895 1.0 0.9720257455208068 5 O75648 1 Creb1 phosphorylation through nmda receptor mediated activation of ras signaling 0.4134991195610146 0.4235230777191177 0.671913664649501 1.0 0.9720257455208068 8 P07196 1 Acyl chain remodelling of ps 0.705087157595168 0.422315287284218 0.6727949012618788 1.0 0.9720257455208068 2 Q9BZF1 1 Acyl chain remodelling of pc 0.705087157595168 0.422315287284218 0.6727949012618788 1.0 0.9720257455208068 2 Q8NF37 1 G beta gamma signalling through cdc42 0.5193307779569565 0.4204476118550195 0.6741584926373028 1.0 0.9720257455208068 3 P63218 1 Pregnenolone biosynthesis 0.4913211252182066 0.4065464252268895 0.6843411527582299 1.0 0.9770474636247454 4 P30536 1 Synthesis of bile acids and bile salts 0.4906705232483881 0.4043269972700875 0.685972275372219 1.0 0.9770474636247454 4 O14734,P22307 2 Bile acid and bile salt metabolism 0.4906705232483881 0.4043269972700875 0.685972275372219 1.0 0.9770474636247454 4 O14734,P22307 2 Platelet activation signaling and aggregation 0.3044591538634152 0.3901240066761041 0.6964448517432564 1.0 0.9821834096390836 52 P63096,Q6UXV4,Q8NBX0,Q96JJ7,Q8N2K0,Q08380,P04899,Q8NCG7,Q12846,P07602,P63218,Q9NZJ7,Q9NUQ9,O43852,Q06481,P05067 16 Collagen formation 0.3684080561074657 0.3776763485705879 0.7056710398241783 1.0 0.9864304915722716 12 O75718,Q32P28,P13674 3 Intrinsic pathway for apoptosis 0.325039571134771 0.3757470788416157 0.7071049343817628 1.0 0.9864304915722716 17 Q9Y3B8 1 Intra golgi traffic 0.3758588785079028 0.3672500915037893 0.7134324781128394 1.0 0.9882394916351313 11 Q13190,O00461 2 Prevention of phagosomal lysosomal fusion 0.6844539309854214 0.365052416273718 0.7150722796011177 1.0 0.9882394916351313 2 P20339 1 E3 ubiquitin ligases ubiquitinate target proteins 0.3212192888067701 0.3510829334218966 0.725526131183678 1.0 0.9896932764129116 16 O75381 1 Signaling by flt3 fusion proteins 0.4964412811387804 0.347627693907711 0.7281198052314442 1.0 0.9896932764129116 3 Q14789,P62993 2 Autophagy 0.2939777643412478 0.3373893676514657 0.7358233986673341 1.0 0.9922546121198256 48 O96008,Q8N4H5,Q15382,P08670,P04350,P21796,Q9NS69,P67870,Q8IWA4,Q7Z3C6,P50542,Q15388,Q96B49 13 Synthesis of pc 0.4702891497496674 0.3368532705289191 0.7362275133025662 1.0 0.9922546121198256 4 Q9NQZ5,P67870 2 Biosynthesis of the n glycan precursor dolichol lipid linked oligosaccharide llo and transfer to a nascent protein 0.3499510553017364 0.3318165466701438 0.7400277890743976 1.0 0.9922546121198256 13 P10619 1 Phosphorylation of the apc c 0.3932263814616682 0.3313766370314963 0.7403600098814818 1.0 0.9922546121198256 8 Q96DE5,Q9UJX4,Q9UJX3,P14635,P06493,Q9UJX6,P30260 7 Sars cov 2 infection 0.3157507865473394 0.3257320032740331 0.7446271285254826 1.0 0.9950036172899948 20 Q9H0U3,Q10472,P27824 3 Nuclear envelope breakdown 0.279106395674534 0.3031004207413059 0.7618133335198682 1.0 1.0 39 P50402,P57740,P42166,Q99567,P20700,P42167,Q9BTX1,Q9NRG9,O15504,Q8NFH4 10 Chylomicron assembly 0.6577730345073007 0.2969070959863877 0.7665374385201569 1.0 1.0 2 P07237 1 Plasma lipoprotein assembly 0.6577730345073007 0.2969070959863877 0.7665374385201569 1.0 1.0 2 P07237 1 Energy dependent regulation of mtor by lkb1 ampk 0.3965869506472019 0.2882319325306285 0.7731692068661191 1.0 1.0 6 Q9Y2Q5,P54619,Q15382,P42345 4 Thrombin signalling through proteinase activated receptors pars 0.4001508206926785 0.2809035234781787 0.778784398077095 1.0 1.0 5 P63218 1 Signalling to ras 0.4693950177935805 0.2691832307892385 0.78778868406122 1.0 1.0 3 P62993,P11233 2 Apobec3g mediated resistance to hiv 1 infection 0.4683274021352275 0.2662718789364542 0.7900298289026311 1.0 1.0 3 O75475,O75531 2 Unwinding of dna 0.3694721825962917 0.2598605257172471 0.7949713613694385 1.0 1.0 9 P25205,P33992,P33993,P33991,Q9Y248,Q9BRX5,Q9BRT9,Q14566 8 Diseases of glycosylation 0.3031727509374976 0.2428618413643538 0.8081124268433879 1.0 1.0 16 P07686,P10619,O75340,Q8NCH0,P16278,P06865,Q9BT22 7 Notch4 activation and transmission of signal to the nucleus 0.4585317453241747 0.2402551517690714 0.8101324605326372 1.0 1.0 3 Q92542 1 Protein protein interactions at synapses 0.3410661985967854 0.2398264216115267 0.810464823141452 1.0 1.0 12 O95197 1 Rac3 gtpase cycle 0.2918640344559802 0.2331753676414696 0.8156252324748767 1.0 1.0 27 Q9UQB8,P50402,P42167,Q8TAA9,O15173 5 G beta gamma signalling through pi3kgamma 0.4504567907726312 0.2197759086354905 0.8260456830435314 1.0 1.0 3 P63218 1 Metabolism of lipids 0.4012299062147168 0.2182296834310046 0.8272501583585223 1.0 1.0 162 P30536,Q14849,Q99538,Q9UMR5,O95573,O00767,Q9H2C2,O00116,Q9P035,P50897,Q8IV08,O43808,Q9NPH0,O15269,O95674,P17900,P16278,Q9NZJ7,Q10713,P04062,Q8IVS2,Q9NQZ5,Q9NTJ5,Q06136,P22307,P07686,Q15067,Q16836,O95470,Q92604,O15254,P23786,Q8NCC3,Q9UG56,P34913,Q9BZF1,Q5T8D3,P07602,P48739,Q53H12,Q15800,Q53GQ0,Q6UWP7,P10619,Q15185,Q14739,Q16850,Q15165,P51648,P20339,Q16739,Q9H7Z7,P22033,P49748,P38435,P67870,Q16880,Q13510,O43681,P09960,Q96N66,P33121,Q9BVG9,Q15392,P06865,Q9NZ01,Q9Y2W1,Q96G23,Q9BTU6,Q14534,O95864,P06280,Q8N5B7 73 Pi5p regulates tp53 acetylation 0.6211312700106817 0.2153242491007607 0.8295145249652551 1.0 1.0 2 P04637 1 Pka mediated phosphorylation of creb 0.613304873710433 0.1998135131449591 0.8416264324852403 1.0 1.0 2 P10644 1 Pka activation in glucagon signalling 0.613304873710433 0.1998135131449591 0.8416264324852403 1.0 1.0 2 P10644 1 Creb1 phosphorylation through the activation of adenylate cyclase 0.613304873710433 0.1998135131449591 0.8416264324852403 1.0 1.0 2 P10644 1 Sumoylation of rna binding proteins 0.2790278842389375 0.1927705940307665 0.8471386340764324 1.0 1.0 30 Q8NFH4,P61978,P57740,Q99567,Q9BTX1,Q9NRG9,O15504,P07910 8 Stimuli sensing channels 0.3599026100490695 0.1925199116615936 0.8473349723828392 1.0 1.0 8 P51798,Q9C0H2 2 Tp53 regulates transcription of death receptors and ligands 0.6090359302739339 0.1916451993782083 0.848020134704337 1.0 1.0 2 P04637 1 Caspase activation via death receptors in the presence of ligand 0.6090359302739337 0.1916451993782077 0.8480201347043375 1.0 1.0 2 Q13546 1 Regulation by c flip 0.6090359302739337 0.1916451993782077 0.8480201347043375 1.0 1.0 2 Q13546 1 Antigen activates b cell receptor bcr leading to generation of second messengers 0.607612949128434 0.1889684712757536 0.8501175278307553 1.0 1.0 2 P62993 1 Leishmania infection 0.2626235335733934 0.1864351460703022 0.8521035329735147 1.0 1.0 36 Q9UQB8,P63096,P09601,P04899,P63218,P05067 6 Cargo trafficking to the periciliary membrane 0.292756506333148 0.1815165150138664 0.8559621713596903 1.0 1.0 17 O43924,Q10713 2 Glutamate and glutamine metabolism 0.3620812544547317 0.1781957716976955 0.8585692302783605 1.0 1.0 7 Q96C36,O94925,P32322,P54886,P04181,P00367 6 Constitutive signaling by akt1 e17k in cancer 0.60085378868731 0.1765694752011394 0.859846572570095 1.0 1.0 2 P42345 1 Flt3 signaling in disease 0.4101103595585724 0.1655239516609039 0.8685315991482538 1.0 1.0 4 Q14789,Q01082,P62993 3 Cytoprotection by hmox1 0.2877517515247528 0.1396695365752338 0.8889210967258869 1.0 1.0 61 Q8TCT9,P20674,P30519,O75880,P13073,P09601,O43819 7 G alpha q signalling events 0.3180708660843185 0.1357614920982202 0.8920098339953975 1.0 1.0 12 P63218,Q8NCG7,Q8N2K0,P05067 4 Regulation of ifng signaling 0.4099644128113917 0.1310651636344222 0.8957237587850553 1.0 1.0 3 P42224,P18031 2 Regulation of ifna signaling 0.4099644128113917 0.1310651636344222 0.8957237587850553 1.0 1.0 3 P42224,P18031 2 Gab1 signalosome 0.4099644128113874 0.1310651636344143 0.8957237587850615 1.0 1.0 3 P62993,P41240 2 Flt3 signaling 0.4099644128113874 0.1310651636344143 0.8957237587850615 1.0 1.0 3 P62993,P41240 2 Signaling by type 1 insulin like growth factor 1 receptor igf1r 0.4099644128113787 0.1310651636343975 0.8957237587850748 1.0 1.0 3 O14654,P62993 2 Slc transporter disorders 0.2611552336016462 0.1232068673836693 0.9019432876185968 1.0 1.0 33 P35613,P57740,Q99567,Q9BTX1,Q9NRG9,O00400,O15504,Q8NFH4,P53985 9 Signaling by pdgfra transmembrane juxtamembrane and kinase domain mutants 0.5553183920313174 0.1066256724995101 0.9150859509765736 1.0 1.0 2 P62993 1 Interleukin 2 family signaling 0.5553183920313174 0.1066256724995101 0.9150859509765736 1.0 1.0 2 P62993 1 Signaling by kit in disease 0.5553183920313174 0.1066256724995101 0.9150859509765736 1.0 1.0 2 P62993 1 Nuclear envelope ne reassembly 0.2657063739925093 0.0954766167181488 0.9239362625562808 1.0 1.0 47 Q8IXJ6,Q9UQN3,Q14739,P68371,P50402,P37198,Q7Z3B4,P57740,P04350,P42166,P20700,P42167,Q9BTX1,Q86XL3,Q8N1F7,Q8NFH4,Q9BVA1 17 Biological oxidations 0.2529562332832868 0.0918512082449006 0.9268162576900808 1.0 1.0 37 Q15185,Q16850,Q8TB61,O43169,P21964 5 Rip mediated nfkb activation via zbp1 0.3850533807829192 0.08852417605225 0.929460070055139 1.0 1.0 3 Q13546,Q9NZI8 2 Zbp1 dai mediated induction of type i ifns 0.3850533807829192 0.08852417605225 0.929460070055139 1.0 1.0 3 Q13546,Q9NZI8 2 Response of eif2ak1 hri to heme deficiency 0.3786476868327402 0.0790678908511405 0.9369786229187536 1.0 1.0 3 P08243,P05198 2 Small interfering rna sirna biogenesis 0.4934187122020775 0.047112191879104 0.9624238104139352 1.0 1.0 2 Q99598 1 Regulation of innate immune responses to cytosolic dna 0.4813233724653294 0.0395944879686381 0.9684164219585978 1.0 1.0 2 Q9NZI8 1 Notch3 intracellular domain regulates transcription 0.4784774101743299 0.0379922675854529 0.9696938471517856 1.0 1.0 2 P42224 1 Activation of ppargc1a pgc 1alpha by phosphorylation 0.4692280327285764 0.0331968586194751 0.9735176032019132 1.0 1.0 2 P54619 1 Interleukin 12 family signaling 0.2579746895357558 0.0262658921969661 0.9790452596037746 1.0 1.0 29 P07237,O14979,P22626,P52597,P14174,P11233,P20700,P27824,Q13126 9 Regulation of tp53 activity through methylation 0.4108858057630873 0.014686020081972 0.988282672515743 1.0 1.0 2 P04637 1 Pi 3k cascade fgfr4 0.4098185699039605 0.0144937838901339 0.9884360384809918 1.0 1.0 2 P62993 1 Frs mediated fgfr4 signaling 0.4098185699039605 0.0144937838901339 0.9884360384809918 1.0 1.0 2 P62993 1 Pi 3k cascade fgfr3 0.4098185699039605 0.0144937838901339 0.9884360384809918 1.0 1.0 2 P62993 1 Stat5 activation 0.4098185699039605 0.0144937838901339 0.9884360384809918 1.0 1.0 2 P62993 1 Frs mediated fgfr3 signaling 0.4098185699039605 0.0144937838901339 0.9884360384809918 1.0 1.0 2 P62993 1 Frs mediated fgfr2 signaling 0.4098185699039605 0.0144937838901339 0.9884360384809918 1.0 1.0 2 P62993 1 Frs mediated fgfr1 signaling 0.4098185699039605 0.0144937838901339 0.9884360384809918 1.0 1.0 2 P62993 1 Pi 3k cascade fgfr2 0.4098185699039605 0.0144937838901339 0.9884360384809918 1.0 1.0 2 P62993 1 Signaling by flt3 itd and tkd mutants 0.4098185699039605 0.0144937838901339 0.9884360384809918 1.0 1.0 2 P62993 1 Tie2 signaling 0.4098185699039605 0.0144937838901339 0.9884360384809918 1.0 1.0 2 P62993 1 Stat5 activation downstream of flt3 itd mutants 0.4098185699039605 0.0144937838901339 0.9884360384809918 1.0 1.0 2 P62993 1 Pi 3k cascade fgfr1 0.4098185699039605 0.0144937838901339 0.9884360384809918 1.0 1.0 2 P62993 1 Irs mediated signalling 0.4098185699039605 0.0144937838901339 0.9884360384809918 1.0 1.0 2 P62993 1 Activated ntrk2 signals through frs2 and frs3 0.4098185699039605 0.0144937838901339 0.9884360384809918 1.0 1.0 2 P62993 1 Glycerophospholipid catabolism 0.4091070793312161 0.0143678523657862 0.9885365068381832 1.0 1.0 2 Q8N9F7 1 G protein beta gamma signalling 0.3266969422718301 0.0139821095363269 0.98884425416494 1.0 1.0 4 P63218 1 Tp53 regulates transcription of genes involved in g1 cell cycle arrest 0.4041266453219637 0.0135345939701136 0.9892012861296716 1.0 1.0 2 P04637 1 Tp53 regulates transcription of genes involved in cytochrome c release 0.3980789754535902 0.0126299458876824 0.9899230290787197 1.0 1.0 2 P04637 1 Rhod gtpase cycle 0.2610774976427072 0.0102177174443055 0.991847582859225 1.0 1.0 24 Q14739,P50402,P42166,P20700,P42167,Q8TAA9,O15173 7 Synthesis of pips at the plasma membrane 0.310593043244152 0.0075001107298311 0.9940158335476256 1.0 1.0 6 Q9BTU6,P20339 2 Insulin processing 0.3068018621392439 0.0057943596347265 0.9953767957781016 1.0 1.0 7 Q8TAD4,Q9UPT5,Q8NEW0 3 Pyruvate metabolism and citric acid tca cycle 0.24282735490053 0.0050923127751705 0.9959369398182284 1.0 1.0 34 Q15120,P21912,P35613,O43837,O95563,P21796,P53985 7