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interpro_active_site/advanced/idx2term.json

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+{}

interpro_active_site/basic/idx2term.json

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+{}

interpro_active_site/consensus.joblib

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+version https://git-lfs.github.com/spec/v1
+oid sha256:6f422ef0147679eaa41845b00b93083e27c5be8b1dbb8fdbc5058138db9ee1da
+size 67115

interpro_active_site/df_merge.tsv

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+term	overlap	setsize	score	pval	overlap_mean	setsize_mean	score_mean	pval_mean	overlap_std	setsize_std	score_std	pval_std	pval_hit	pval_50	pval_100	pval_250	pval_500

interpro_active_site/metrics.json

@@ -0,0 +1,7 @@
+{
+    "type_of_task": "ranksum",
+    "signature_size": 2813,
+    "annotations_size": 57,
+    "title": "Average number of proteins per term",
+    "value": 2.175438596491228
+}

interpro_active_site/paths.json

@@ -0,0 +1 @@
+{"results_path": "results/proteins/hek293t_core/interpro_active_site/fragment/C234/C234_val_log2fc"}

interpro_active_site/result.tsv

@@ -0,0 +1,6 @@
+Term	es	nes	pval	sidak	fdr	geneset_size	leading_edge	leading_edge_size
+Serine carboxypeptidase, serine active site [IPR018202]	0.8921708185053355	1.433310144969297	0.1517692240413362	0.9999158024478456	0.3417414207838706	3	Q9H3G5,P10619	2
+ATPase, alpha/beta subunit, nucleotide-binding domain, active site [IPR020003]	0.6336053691710579	0.841233168218653	0.400217322525467	0.9999999999997784	0.6809894428192668	4	P21281	1
+Ubiquitin-conjugating enzyme, active site [IPR023313]	0.3842592592592631	0.1315631881058681	0.8953298039991711	1.0	0.9743580155941088	5	P61081,P60604,P61088,P61086	4
+Glycosyl hydrolases family 31, active site [IPR030458]	0.5233013162575726	0.0616258973192325	0.9508607530559432	1.0	0.9743580155941088	2	P10253	1
+Phosphoglycerate/bisphosphoglycerate mutase, active site [IPR001345]	0.5115617218071958	0.0535872495254688	0.957264015320528	1.0	0.9743580155941088	2	Q9NQ88	1

interpro_active_site/selections.json

@@ -0,0 +1 @@
+{"all_annotations": ["ATP synthase, F0 complex, subunit A, active site [IPR023011]", "ATP-citrate lyase/succinyl-CoA ligase, active site [IPR017440]", "ATP:guanido phosphotransferase active site [IPR022415]", "ATPase, alpha/beta subunit, nucleotide-binding domain, active site [IPR020003]", "Adenosine/AMP deaminase active site [IPR006650]", "Adenylosuccinate synthase,  active site [IPR033128]", "Beta-ketoacyl synthase, active site [IPR018201]", "Citrate synthase active site [IPR019810]", "ClpP, Ser active site [IPR018215]", "ClpP, histidine active site [IPR033135]", "Cysteine peptidase, asparagine active site [IPR025661]", "Cysteine peptidase, cysteine active site [IPR000169]", "Cysteine peptidase, histidine active site [IPR025660]", "DNA methylase, C-5 cytosine-specific, active site [IPR018117]", "DNA topoisomerase I, active site [IPR018521]", "Ferrochelatase, active site [IPR019772]", "Glucose-6-phosphate dehydrogenase, active site [IPR019796]", "Glutaredoxin active site [IPR011767]", "Glyceraldehyde 3-phosphate dehydrogenase, active site [IPR020830]", "Glycoside hydrolase, family 2, active site [IPR023232]", "Glycosyl hydrolases family 31, active site [IPR030458]", "Histidine acid phosphatase active site [IPR033379]", "Hydroxymethylglutaryl-CoA lyase, active site [IPR000138]", "Hydroxymethylglutaryl-coenzyme A synthase, active site [IPR000590]", "L-lactate dehydrogenase, active site [IPR018177]", "Leu/Phe/Val dehydrogenases active site [IPR033524]", "Lipase, GDXG, putative serine active site [IPR033140]", "Malate dehydrogenase, active site [IPR001252]", "Nucleoside diphosphate kinase, active site [IPR023005]", "Orotidine 5'-phosphate decarboxylase, active site [IPR018089]", "Peptidase S16, active site [IPR008268]", "Peptidase S26A, signal peptidase I, serine active site [IPR019756]", "Peptidase S8, subtilisin, His-active site [IPR022398]", "Peptidase S8, subtilisin, Ser-active site [IPR023828]", "Peptidase S9, serine active site [IPR002471]", "Peptidase family C14A, His active site [IPR016129]", "Peptidase family C14A, cysteine active site [IPR033139]", "Phosphoglycerate/bisphosphoglycerate mutase, active site [IPR001345]", "Phosphoribosylglycinamide formyltransferase, active site [IPR001555]", "Protein-tyrosine phosphatase, active site [IPR016130]", "Pyridine nucleotide-disulphide oxidoreductase, class I, active site [IPR012999]", "Pyruvate kinase, active site [IPR018209]", "Ribonuclease T2, His active site 1 [IPR018188]", "Ribonuclease T2, His active site 2 [IPR033130]", "Ribonucleotide reductase small subunit, acitve site [IPR030475]", "Serine carboxypeptidase, serine active site [IPR018202]", "Serine carboxypeptidases, histidine active site [IPR033124]", "Serine/threonine-protein kinase, active site [IPR008271]", "Thermonuclease active site [IPR002071]", "Thiolase, active site [IPR020610]", "Thiolase, acyl-enzyme intermediate active site [IPR020615]", "Thymidylate synthase, active site [IPR020940]", "Transaldolase, active site [IPR018225]", "Triosephosphate isomerase, active site [IPR020861]", "Tyrosine-protein kinase, active site [IPR008266]", "Ubiquitin-activating enzyme E1, Cys active site [IPR033127]", "Ubiquitin-conjugating enzyme, active site [IPR023313]"], "available_proteins": ["ACAA1", "ACAA2", "ACAT1", "ACAT2", "ACLY", "ACP2", "ACP6", "ADA", "ADSS", "APEH", "ATP5A1", "ATP5B", "ATP6", "ATP6V1A", "ATP6V1B2", "AURKB", "BLMH", "CAMK1", "CAMK2G", "CAPN1", "CASP3", "CDK1", "CDK2", "CDK4", "CDK5", "CDK6", "CKB", "CKMT1A*", "CLPP", "CPVL", "CS", "CSK", "CSNK1A1", "CSNK2A2", "CTSA", "CTSC", "DLD", "DNMT1", "DUSP3", "EIF2AK2", "FASN", "FECH", "G6PD", "GAA", "GAK", "GANAB", "GAPDH", "GART", "GLRX", "GLUD1", "GSR", "GUSB", "HADHB", "HMGCL", "HMGCS1", "LDHA", "LDHB", "LONP1", "MAP2K1", "MAP2K2", "MAPK1", "MAPK3", "MASTL", "MDH1", "MDH2", "MTMR6", "NCEH1", "NEK9", "NME1", "PAK2", "PBK", "PGAM1", "PKM", "PKMYT1", "PKN2", "PLK1", "PREP", "PRPF4B", "PTK2", "PTPMT1", "PTPN1", "PTPN11", "PTPRF", "RIPK1", "RNASET2", "RPS6KA1", "RPS6KA3", "RRM2", "SCP2", "SCPEP1", "SEC11A", "SLK", "SND1", "SRPK1", "SUCLG1", "TALDO1", "TIGAR", "TOP1", "TPI1", "TPP2", "TTK", "TYMS", "UBA1", "UBA2", "UBA3", "UBE2G2", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UMPS", "VRK1", "WNK1"], "leading_proteins": ["ATP6V1B2", "CPVL", "CTSA", "GAA", "TIGAR", "UBE2G2", "UBE2K", "UBE2M", "UBE2N"]}

interpro_binding_site/advanced/idx2term.json

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+{}

interpro_binding_site/basic/idx2term.json

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+{"0": "EF-Hand 1, calcium-binding site [IPR018247]"}

interpro_binding_site/consensus.joblib

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+version https://git-lfs.github.com/spec/v1
+oid sha256:6d75276e703323195c7a1058ca0df490e17590a6d547ec8e0c91f484b9a02b6a
+size 63492

interpro_binding_site/df_merge.tsv

@@ -0,0 +1 @@
+term	overlap	setsize	score	pval	overlap_mean	setsize_mean	score_mean	pval_mean	overlap_std	setsize_std	score_std	pval_std	pval_hit	pval_50	pval_100	pval_250	pval_500

interpro_binding_site/metrics.json

@@ -0,0 +1,7 @@
+{
+    "type_of_task": "ranksum",
+    "signature_size": 2813,
+    "annotations_size": 31,
+    "title": "Average number of proteins per term",
+    "value": 3.838709677419355
+}

interpro_binding_site/paths.json

@@ -0,0 +1 @@
+{"results_path": "results/proteins/hek293t_core/interpro_binding_site/fragment/C234/C234_val_log2fc"}

interpro_binding_site/result.tsv

@@ -0,0 +1,3 @@
+Term	es	nes	pval	sidak	fdr	geneset_size	leading_edge	leading_edge_size
+EF-Hand 1, calcium-binding site [IPR018247]	0.4757692870851169	1.4866029543306227	0.137119707079758	0.989661273145562	0.42507109194725	35	P80303,Q9BRK5,O95202,O43852,Q9NWM8,Q9Y680,Q9UBC2,Q96D71,Q14257,Q9BPX6,Q6NUK1,Q96AY3	12
+Peptidase M16, zinc-binding site [IPR001431]	0.5947194204902466	0.8695326524117696	0.384555856378562	0.9999997083594246	0.6622906415408568	5	Q10713	1

interpro_binding_site/selections.json

@@ -0,0 +1 @@
+{"all_annotations": ["2-oxo acid dehydrogenase, lipoyl-binding site [IPR003016]", "2Fe-2S ferredoxin, iron-sulphur binding site [IPR006058]", "6-phosphogluconate-binding site [IPR006184]", "AP endonuclease 1, binding site [IPR020847]", "APOBEC/CMP deaminase, zinc-binding [IPR016192]", "Aconitase family, 4Fe-4S cluster binding site [IPR018136]", "Adenylosuccinate synthase, GTP-binding site [IPR018220]", "Aminotransferase class-V, pyridoxal-phosphate binding site [IPR020578]", "Aminotransferase, class-II, pyridoxal-phosphate binding site [IPR001917]", "Aminotransferases, class-I, pyridoxal-phosphate-binding site [IPR004838]", "Beta tubulin, autoregulation binding site [IPR013838]", "Biotin-binding site [IPR001882]", "Copper centre Cu(A) [IPR001505]", "Cytochrome b5, heme-binding site [IPR018506]", "Cytochrome c oxidase, subunit Vb, zinc binding site [IPR020893]", "EF-Hand 1, calcium-binding site [IPR018247]", "Fumarate reductase/succinate dehydrogenase, FAD-binding site [IPR003952]", "Hexokinase, binding site [IPR019807]", "IQ motif, EF-hand binding site [IPR000048]", "Inositol monophosphatase, metal-binding site [IPR020583]", "Manganese/iron superoxide dismutase, binding site [IPR019833]", "PPM-type phosphatase, divalent cation binding [IPR000222]", "Peptidase M16, zinc-binding site [IPR001431]", "Peptidase M24A, methionine aminopeptidase, subfamily 2, binding site [IPR018349]", "Porphobilinogen deaminase, dipyrromethane cofactor binding site [IPR022419]", "Protein kinase, ATP binding site [IPR017441]", "RNA polymerases, subunit N, zinc binding site [IPR020789]", "Serine hydroxymethyltransferase, pyridoxal phosphate binding site [IPR019798]", "Sigma-54 interaction domain, ATP-binding site 1 [IPR025662]", "Transketolase binding site [IPR020826]", "Ureohydrolase, manganese-binding site [IPR020855]"], "available_proteins": ["ACACA", "ACO1", "ACO2", "ACTN1", "ACTN4", "ADSS", "APEX1", "APOBEC3C", "ARG2", "AURKB", "BPNT1", "CALM3", "CALU", "CAMK1", "CAMK2G", "CAPN1", "CAPNS1", "CDK1", "CDK2", "CDK4", "CDK5", "CDK6", "CETN2", "COX2", "COX5B", "CSK", "CSNK1A1", "CSNK2A2", "CYB5B", "DBT", "DLAT", "DLST", "EHD1", "EHD4", "EIF2AK2", "EPS15L1", "FKBP10", "FKBP14", "FKBP7", "GCAT", "GOT1", "GOT2", "GPD2", "HK1", "HK2", "HMBS", "IDE", "ILKAP", "IQGAP1", "IQGAP2", "LETM1", "MACF1", "MAP2K1", "MAP2K2", "MAPK1", "MAPK14", "MAPK3", "MCCC1", "MICU1", "MYH10", "MYH9", "MYO1B", "MYO1C", "NFS1", "NRDC", "NUCB1", "NUCB2", "OXSR1", "PA2G4", "PAK2", "PC", "PCCA", "PDCD6", "PDHX", "PEF1", "PGD", "PKMYT1", "PKN2", "PLCG1", "PLK1", "PLS3", "PMPCA", "PMPCB", "POLR2L", "PPM1G", "PRKCSH", "PSAT1", "PTK2", "RAB18", "RCN1", "RCN2", "REPS1", "RHOT1", "RHOT2", "RPS6KA1", "RPS6KA3", "S100A11", "SDF4", "SDHA", "SDHB", "SHMT1", "SHMT2", "SLC25A12", "SLC25A24", "SLK", "SOD2", "SPTAN1", "SRI", "SRPK1", "TKT", "TTK", "TUBB", "TUBB2A", "TUBB2B", "TUBB4A", "TUBB4B", "TUBB6", "UQCRC2", "VRK1"], "leading_proteins": ["CALU", "EPS15L1", "FKBP10", "FKBP14", "FKBP7", "LETM1", "MICU1", "NUCB2", "PMPCA", "RCN2", "REPS1", "SDF4", "SLC25A24"]}

interpro_conserved_site/advanced/idx2term.json

@@ -0,0 +1 @@
+{"0": "Proteasome beta-type subunit, conserved site [IPR016050]"}

interpro_conserved_site/basic/idx2term.json

@@ -0,0 +1 @@
+{"0": "Proteasome beta-type subunit, conserved site [IPR016050]", "1": "Mini-chromosome maintenance, conserved site [IPR018525]", "2": "14-3-3 protein, conserved site [IPR023409]"}

interpro_conserved_site/consensus.joblib

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+version https://git-lfs.github.com/spec/v1
+oid sha256:1aed76474eb1bf5ba8cae7b4c004f4ceadb782c8dc0fa5e93f02a15a77589c39
+size 71517

interpro_conserved_site/df_merge.tsv

@@ -0,0 +1,3 @@
+term	overlap	setsize	score	pval	overlap_mean	setsize_mean	score_mean	pval_mean	overlap_std	setsize_std	score_std	pval_std	pval_hit	pval_50	pval_100	pval_250	pval_500
+Thioredoxin, conserved site [IPR017937]	4	12	2.467223229442291	0.0136165440605526	3.905339805825242	10.99514563106796	0.4926509002179139	0.4659055513701703	2.3960466288532025	1.0404329420711995	1.0069927416530815	0.3218319873274993	0.0346774404500595	1.0	1.0	0.0040998381065295	0.0003637398802397
+Proteasome beta-type subunit, conserved site [IPR016050]	5	8	2.006782205969956	0.0447728583483519	3.7135922330097086	7.970873786407767	1.4913184573846054	0.1902243906475925	1.515457478026574	0.1681602725795027	1.0170822776023185	0.2455850375425174	0.018130478052899	1.0	0.0921025797166938	0.0227865880642579	0.0009048869233579

interpro_conserved_site/metrics.json

@@ -0,0 +1,7 @@
+{
+    "type_of_task": "ranksum",
+    "signature_size": 2813,
+    "annotations_size": 264,
+    "title": "Average number of proteins per term",
+    "value": 2.492424242424242
+}

interpro_conserved_site/paths.json

@@ -0,0 +1 @@
+{"results_path": "results/proteins/hek293t_core/interpro_conserved_site/fragment/C234/C234_val_log2fc"}

interpro_conserved_site/result.tsv

@@ -0,0 +1,34 @@
+Term	es	nes	pval	sidak	fdr	geneset_size	leading_edge	leading_edge_size
+Thioredoxin, conserved site [IPR017937]	0.7304595621354928	2.467223229442291	0.0136165440605526	0.9732030244578244	0.5248370227812336	12	P07237,Q96JJ7,Q9H1E5,Q9H3N1	4
+Proteasome beta-type subunit, conserved site [IPR016050]	0.7284749928353031	2.0067822059699556	0.0447728583483519	0.9999944004047512	0.5248370227812336	8	Q99436,P49721,P28072,P28070,P28074	5
+Intermediate filament protein, conserved site [IPR018039]	0.675135848313019	1.7453840988251013	0.0809180316913347	0.9999999997883976	0.5265299603518464	8	Q16352,P48681,P08670	3
+Haem oxygenase conserved site [IPR018207]	0.9911063678406262	1.3061673483634302	0.1914956539486105	1.0	0.6740647018991092	2	P30519	1
+Syntaxin/epimorphin, conserved site [IPR006012]	0.6363390569724063	1.266909518743348	0.2051876447495046	1.0	0.6905049178942941	6	Q13190,O15400,Q9P2W9	3
+Tetraspanin, conserved site [IPR018503]	0.9793667733902534	1.2628909699952595	0.2066283655820047	1.0	0.6905049178942941	2	O60637	1
+Quinone oxidoreductase/zeta-crystallin, conserved site [IPR002364]	0.8056939501779429	1.1072015175854188	0.2682068115734188	1.0	0.7532616835678997	3	Q8N4Q0,Q99536	2
+Aldehyde dehydrogenase, cysteine active site [IPR016160]	0.5262451757956396	0.9368399123264128	0.3488409114034234	1.0	0.8296756811757098	7	O94788,P51648,P30837,P05091	4
+Short-chain dehydrogenase/reductase, conserved site [IPR020904]	0.4509584047939918	0.8499551764474669	0.3953500072604128	1.0	0.8845118806504151	12	Q9Y394,Q8NBN7,Q06136	3
+Aldehyde dehydrogenase, glutamic acid active site [IPR029510]	0.4434892274936207	0.5388712349842997	0.5899757065494047	1.0	0.9725410206461764	7	O94788,P51648	2
+Calreticulin/calnexin, conserved site [IPR018124]	0.6342034601192534	0.5023581765163376	0.6154155931503924	1.0	0.9725410206461764	3	P27824	1
+3-hydroxyacyl-CoA dehydrogenase, conserved site [IPR006180]	0.7506225542511606	0.4819293503346813	0.6298561353284087	1.0	0.9725410206461764	2	Q16836	1
+Amyloidogenic glycoprotein, intracellular domain, conserved site [IPR019745]	0.7499110636784108	0.4798662263046584	0.6313225178864823	1.0	0.9725410206461764	2	Q06481	1
+Amyloidogenic glycoprotein,  copper-binding domain conserved site [IPR019744]	0.7499110636784108	0.4798662263046584	0.6313225178864823	1.0	0.9725410206461764	2	Q06481	1
+Proteinase inhibitor I2, Kunitz, conserved site [IPR020901]	0.7499110636784108	0.4798662263046584	0.6313225178864823	1.0	0.9725410206461764	2	Q06481	1
+Sterol reductase, conserved site [IPR018083]	0.6210657456944615	0.4616740029328127	0.6443151167713987	1.0	0.9725410206461764	3	Q14739	1
+Mini-chromosome maintenance, conserved site [IPR018525]	0.4495903099394264	0.4384194900829644	0.6610822205140932	1.0	0.9725410206461764	6	P33993,Q14566,P33992,P33991,P49736	5
+Eukaryotic translation initiation factor 4E (eIF-4E), conserved site [IPR019770]	0.7107790821771671	0.3723535632186979	0.7096296232995369	1.0	0.9743549272657952	2	P06730	1
+14-3-3 protein, conserved site [IPR023409]	0.4271464196651119	0.3514973064850355	0.7252152928487474	1.0	0.9818299349336888	6	P62258,Q04917,P61981,P31946,P63104	5
+Cyclic nucleotide-binding, conserved site [IPR018488]	0.6527926004980515	0.2378789080603779	0.8119750149337897	1.0	1.0	2	P10644	1
+Dynamin, GTPase region, conserved site [IPR019762]	0.6168623265741824	0.1715627983267192	0.8637812563630356	1.0	1.0	2	O00429	1
+Procollagen-lysine 5-dioxygenase, conserved site [IPR001006]	0.4772241992882466	0.1219128337451116	0.9029680515873452	1.0	1.0	3	Q02809,O60568	2
+Heat shock protein Hsp90, conserved site [IPR019805]	0.4498220640569443	0.0836395610969441	0.9333430119128014	1.0	1.0	3	P14625,P07900	2
+Translation elongation factor EF1B, beta/delta chains, conserved site [IPR001326]	0.5400213447171949	0.0750654503809033	0.9401626368412396	1.0	1.0	2	P24534	1
+Polyamine biosynthesis domain, conserved site [IPR030373]	0.539309854144445	0.0744435067681851	0.9406574914249513	1.0	1.0	2	P19623	1
+CAP, conserved site, N-terminal [IPR018106]	0.5318392031305711	0.0681854954174492	0.9456379730782212	1.0	1.0	2	P40123	1
+CAP, conserved site, C-terminal [IPR028417]	0.5318392031305711	0.0681854954174492	0.9456379730782212	1.0	1.0	2	P40123	1
+DnaJ domain, conserved site [IPR018253]	0.3120749646997661	0.0643360363685582	0.9487026600055196	1.0	1.0	9	Q9NVH1	1
+Glycosyl hydrolases family 31, conserved site [IPR030459]	0.5233013162575726	0.0616258973192325	0.9508607530559432	1.0	1.0	2	P10253	1
+DNA-directed RNA polymerase, 30-40kDa subunit, conserved site [IPR001514]	0.4781216648879549	0.0362310657918566	0.971098115324655	1.0	1.0	2	O15160	1
+D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site 1 [IPR029752]	0.3846975088967969	0.0255969745051231	0.9795787992759356	1.0	1.0	3	O43175,Q13363	2
+IMP dehydrogenase / GMP reductase, conserved site [IPR015875]	0.4283173247954559	0.0220860653701082	0.982379301989913	1.0	1.0	2	P20839	1
+Clathrin adaptor, mu subunit, conserved site [IPR018240]	0.3621850097675949	0.0144744021216163	0.9884515012728065	1.0	1.0	3	Q9BXS5	1

interpro_conserved_site/selections.json

@@ -0,0 +1 @@
+{"all_annotations": ["14-3-3 protein, conserved site [IPR023409]", "3-hydroxyacyl-CoA dehydrogenase, conserved site [IPR006180]", "4Fe-4S ferredoxin, iron-sulphur binding, conserved site [IPR017900]", "ABC transporter-like, conserved site [IPR017871]", "AMP-binding, conserved site [IPR020845]", "AP endonuclease 1, conserved site [IPR020848]", "AT hook, DNA-binding motif [IPR017956]", "ATP synthase, F1 complex, gamma subunit conserved site [IPR023632]", "ATP-citrate lyase/succinyl-CoA ligase, conserved site [IPR033847]", "ATP-dependent RNA helicase DEAD-box, conserved site [IPR000629]", "ATPase, AAA-type, conserved site [IPR003960]", "ATPase, OSCP/delta subunit, conserved site [IPR020781]", "Acin1, RNSP1-SAP18 binding (RSB) motif [IPR032552]", "Actin, conserved site [IPR004001]", "Actin/actin-like conserved site [IPR020902]", "Actinin-type actin-binding domain, conserved site [IPR001589]", "Acyl-CoA dehydrogenase, conserved site [IPR006089]", "Acyl-CoA-binding protein, ACBP, conserved site [IPR022408]", "Adenylate kinase, conserved site [IPR033690]", "Alanine dehydrogenase/NAD(P) transhydrogenase, conserved site-1 [IPR008142]", "Alanine dehydrogenase/pyridine nucleotide transhydrogenase, conserved site-2 [IPR008143]", "Alcohol dehydrogenase, zinc-type, conserved site [IPR002328]", "Aldehyde dehydrogenase, cysteine active site [IPR016160]", "Aldehyde dehydrogenase, glutamic acid active site [IPR029510]", "Aldo/keto reductase, conserved site [IPR018170]", "Aldose 1-epimerase, conserved site [IPR018052]", "Alpha-D-phosphohexomutase, conserved site [IPR016066]", "Aminoacyl-tRNA synthetase, class I, conserved site [IPR001412]", "Aminotransferase, class IV, conserved site [IPR018300]", "Amyloidogenic glycoprotein,  copper-binding domain conserved site [IPR019744]", "Amyloidogenic glycoprotein, intracellular domain, conserved site [IPR019745]", "Annexin repeat, conserved site [IPR018252]", "Apoptosis regulator, Bcl-2, BH1 motif, conserved site [IPR020717]", "Apoptosis regulator, Bcl-2, BH2 motif, conserved site [IPR020726]", "Apoptosis regulator, Bcl-2, BH3 motif, conserved site [IPR020728]", "ArgE/DapE/ACY1/CPG2/YscS, conserved site [IPR001261]", "BUD31/G10-related, conserved site [IPR018230]", "Bacterial Fmu (Sun)/eukaryotic nucleolar NOL1/Nop2p, conserved site [IPR018314]", "Bax inhibitor 1, conserved site [IPR006213]", "Bromodomain, conserved site [IPR018359]", "CAP, conserved site, C-terminal [IPR028417]", "CAP, conserved site, N-terminal [IPR018106]", "Cadherin conserved site [IPR020894]", "Calreticulin/calnexin, conserved site [IPR018124]", "Carbohydrate/purine kinase, PfkB, conserved site [IPR002173]", "Chaperonin Cpn60, conserved site [IPR018370]", "Chaperonin GroES, conserved site [IPR018369]", "Chaperonin TCP-1, conserved site [IPR002194]", "Chromo domain, conserved site [IPR023779]", "Clathrin adaptor complex, small chain [IPR000804]", "Clathrin adaptor, mu subunit, conserved site [IPR018240]", "Coproporphyrinogen III oxidase, conserved site [IPR018375]", "Cullin, conserved site [IPR016157]", "Cyclic nucleotide-binding, conserved site [IPR018488]", "Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site [IPR020892]", "Cytochrome P450, conserved site [IPR017972]", "D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site 1 [IPR029752]", "D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site [IPR029753]", "DNA ligase, ATP-dependent, conserved site [IPR016059]", "DNA methylase, C-5 cytosine-specific,  conserved site [IPR031303]", "DNA methylase, N-6 adenine-specific, conserved site [IPR002052]", "DNA mismatch repair, conserved site [IPR014762]", "DNA topoisomerase, type IIA, conserved site [IPR018522]", "DNA-directed DNA polymerase, family B, conserved site [IPR017964]", "DNA-directed RNA polymerase, 30-40kDa subunit, conserved site [IPR001514]", "DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site [IPR002464]", "Dihydrofolate reductase conserved site [IPR017925]", "Dihydroorotase, conserved site [IPR002195]", "DnaJ domain, conserved site [IPR018253]", "Dynamin, GTPase region, conserved site [IPR019762]", "Dynein light chain, type 1/2, conserved site [IPR019763]", "EGF-like calcium-binding, conserved site [IPR018097]", "EGF-like, conserved site [IPR013032]", "Electron transfer flavoprotein subunit alpha, conserved site [IPR018206]", "Electron transfer flavoprotein, beta-subunit, conserved site [IPR000049]", "Enolase, conserved site [IPR020809]", "Enoyl-CoA hydratase/isomerase, conserved site [IPR018376]", "Ependymin, conserved site [IPR018224]", "Eukaryotic translation initiation factor 4E (eIF-4E), conserved site [IPR019770]", "F-actin capping protein, alpha subunit, conserved site [IPR017865]", "F-actin capping protein, beta subunit, conserved site [IPR019771]", "FERM conserved site [IPR019747]", "FLAP/GST2/LTC4S, conserved site [IPR018295]", "Fatty acid desaturase type 1, conserved site [IPR001522]", "Fibrillarin, conserved site [IPR020813]", "Formate-tetrahydrofolate ligase, FTHFS, conserved site [IPR020628]", "Fructose-bisphosphate aldolase class-I active site [IPR029768]", "Fumarate lyase, conserved site [IPR020557]", "GHMP kinase, ATP-binding, conserved site [IPR006203]", "GTP1/OBG, conserved site [IPR006074]", "Galactokinase, conserved site [IPR019741]", "Gamma-glutamyl phosphate reductase GPR, conserved site [IPR020593]", "Glucosamine-6-phosphate isomerase, conserved site [IPR018321]", "Glutamate 5-kinase, conserved site [IPR019797]", "Glutathione peroxidase conserved site [IPR029760]", "Glycoside hydrolase family 27/36, conserved site [IPR000111]", "Glycoside hydrolase, family 2, conserved site [IPR023230]", "Glycoside hydrolase, family 29, conserved site [IPR018526]", "Glycoside hydrolase, family 35, conserved site [IPR019801]", "Glycosyl hydrolases family 31, conserved site [IPR030459]", "Glyoxalase I, conserved site [IPR018146]", "Golgin subfamily A member 2, C-terminal binding motif [IPR043937]", "Guanylate kinase, conserved site [IPR020590]", "HIND motif [IPR045347]", "HMG box A DNA-binding domain, conserved site [IPR017967]", "HMG-I/HMG-Y, DNA-binding, conserved site [IPR000637]", "Haem oxygenase conserved site [IPR018207]", "Heat shock protein 70, conserved site [IPR018181]", "Heat shock protein Hsp90, conserved site [IPR019805]", "Heavy-metal-associated, conserved site [IPR017969]", "Helix-hairpin-helix motif, class 2 [IPR008918]", "Histidine triad, conserved site [IPR019808]", "Histone H2A conserved site [IPR032458]", "Histone H4, conserved site [IPR019809]", "IMP dehydrogenase / GMP reductase, conserved site [IPR015875]", "Immunoglobulin/major histocompatibility complex, conserved site [IPR003006]", "Inositol monophosphatase, conserved site [IPR020550]", "Intermediate filament protein, conserved site [IPR018039]", "Isocitrate/isopropylmalate dehydrogenase, conserved site [IPR019818]", "Kinesin motor domain, conserved site [IPR019821]", "Lipocalin family conserved site [IPR022272]", "Lysophospholipase patatin, conserved site [IPR001423]", "Lysosome-associated membrane glycoprotein, conserved site [IPR018134]", "Macrophage migration inhibitory factor, conserved site [IPR019829]", "Malic enzyme, conserved site [IPR015884]", "Methylthiotransferase, conserved site [IPR020612]", "Mini-chromosome maintenance, conserved site [IPR018525]", "Mitogen-activated protein (MAP) kinase, conserved site [IPR003527]", "MoaA/NifB/PqqE, iron-sulphur binding, conserved site [IPR000385]", "Mrp, conserved site [IPR000808]", "Myristoyl-CoA:protein N-myristoyltransferase, conserved site [IPR022678]", "NADH:ubiquinone oxidoreductase, 30kDa subunit, conserved site [IPR020396]", "NADH:ubiquinone oxidoreductase, 49kDa subunit, conserved site [IPR014029]", "NADH:ubiquinone oxidoreductase, 51kDa subunit, conserved site [IPR001949]", "NADH:ubiquinone oxidoreductase, 75kDa subunit, conserved site [IPR000283]", "NADH:ubiquinone oxidoreductase, subunit 1, conserved site [IPR018086]", "NUDIX hydrolase, conserved site [IPR020084]", "Oxysterol-binding protein, conserved site [IPR018494]", "P-type trefoil, conserved site [IPR017957]", "Peptidase M22, conserved site [IPR017860]", "Peptidase M24B, X-Pro dipeptidase/aminopeptidase P, conserved site [IPR001131]", "Peptidase S26A, signal peptidase I, conserved site [IPR019758]", "Peptidyl-prolyl cis-trans isomerase, PpiC-type, conserved site [IPR023058]", "Phosphatidylethanolamine-binding, conserved site [IPR001858]", "Phosphatidylinositol 3/4-kinase, conserved site [IPR018936]", "Phosphoenolpyruvate carboxykinase, GTP-utilising, conserved site [IPR018091]", "Phosphofructokinase, conserved site [IPR015912]", "Phosphoglucose isomerase, conserved site [IPR018189]", "Phosphoglycerate kinase, conserved site [IPR015911]", "Phosphomannose isomerase, type I, conserved site [IPR018050]", "Phosphoribosylglycinamide synthetase, conserved site [IPR020559]", "Phosphorylase pyridoxal-phosphate attachment site [IPR035090]", "Polyamine biosynthesis domain, conserved site [IPR030373]", "Polyprenyl synthetase, conserved site [IPR033749]", "Procollagen-lysine 5-dioxygenase, conserved site [IPR001006]", "Profilin conserved site [IPR027310]", "Proliferating cell nuclear antigen, PCNA, conserved site [IPR022659]", "Proteasome beta-type subunit, conserved site [IPR016050]", "Protein phosphatase 2A regulatory subunit PR55, conserved site [IPR018067]", "Proteinase inhibitor I2, Kunitz, conserved site [IPR020901]", "Proteinase inhibitor I25, cystatin, conserved site [IPR018073]", "Pseudouridine synthase TruD, conserved site [IPR020119]", "Purine phosphorylase, family 2, conserved site [IPR018099]", "Quinone oxidoreductase/zeta-crystallin, conserved site [IPR002364]", "RNA 3'-terminal phosphate cyclase-like, conserved site [IPR020719]", "RNA polymerase, beta subunit, conserved site [IPR007121]", "RNA polymerase, subunit H/Rpb5, conserved site [IPR020608]", "Ras GTPase-activating protein, conserved site [IPR023152]", "Rel homology domain, conserved site [IPR030492]", "Retro-transposon transporting motif [IPR018892]", "Ribonuclease II/R, conserved site [IPR022966]", "Ribosomal RNA adenine methylase transferase, conserved site [IPR020596]", "Ribosomal S11, conserved site [IPR018102]", "Ribosomal S24e conserved site [IPR018098]", "Ribosomal protein L1, conserved site [IPR023673]", "Ribosomal protein L10e, conserved site [IPR018255]", "Ribosomal protein L11, conserved site [IPR020785]", "Ribosomal protein L13, conserved site [IPR023563]", "Ribosomal protein L13e, conserved site [IPR018256]", "Ribosomal protein L14P,  conserved site [IPR019972]", "Ribosomal protein L15, conserved site [IPR001196]", "Ribosomal protein L15e, conserved site [IPR020925]", "Ribosomal protein L18e, conserved site [IPR021132]", "Ribosomal protein L19/L19e conserved site [IPR023638]", "Ribosomal protein L2, conserved site [IPR022671]", "Ribosomal protein L21e, conserved site [IPR018259]", "Ribosomal protein L22/L17, conserved site [IPR018260]", "Ribosomal protein L23/L25, conserved site [IPR001014]", "Ribosomal protein L24/L26, conserved site [IPR005825]", "Ribosomal protein L24e, conserved site [IPR023442]", "Ribosomal protein L27e, conserved site [IPR018262]", "Ribosomal protein L29, conserved site [IPR018254]", "Ribosomal protein L3, conserved site [IPR019926]", "Ribosomal protein L30, conserved site [IPR018038]", "Ribosomal protein L30e, conserved site [IPR022991]", "Ribosomal protein L31e, conserved site [IPR020052]", "Ribosomal protein L32e, conserved site [IPR018263]", "Ribosomal protein L34e, conserved site [IPR018065]", "Ribosomal protein L35Ae, conserved site [IPR018266]", "Ribosomal protein L37e, conserved site [IPR018267]", "Ribosomal protein L4/L1e, eukaryotic/archaeal, conserved site [IPR013000]", "Ribosomal protein L5, conserved site [IPR020929]", "Ribosomal protein L6, conserved site-2 [IPR002359]", "Ribosomal protein L7Ae conserved site [IPR004037]", "Ribosomal protein S10, conserved site [IPR018268]", "Ribosomal protein S13, conserved site [IPR018269]", "Ribosomal protein S14, conserved site [IPR018271]", "Ribosomal protein S17, conserved site [IPR019979]", "Ribosomal protein S17e, conserved site [IPR018273]", "Ribosomal protein S19 conserved site [IPR020934]", "Ribosomal protein S19e, conserved site [IPR018277]", "Ribosomal protein S2, conserved site [IPR018130]", "Ribosomal protein S28e conserved site [IPR028626]", "Ribosomal protein S3, conserved site [IPR018280]", "Ribosomal protein S3Ae, conserved site [IPR018281]", "Ribosomal protein S4, conserved site [IPR018079]", "Ribosomal protein S4e, N-terminal, conserved site [IPR018199]", "Ribosomal protein S5, N-terminal, conserved site [IPR018192]", "Ribosomal protein S6e, conserved site [IPR018282]", "Ribosomal protein S7, conserved site [IPR020606]", "Ribosomal protein S8e, conserved site [IPR018283]", "Ribosomal protein S9, conserved site [IPR020574]", "Ribosome maturation protein SBDS, conserved site [IPR018023]", "RidA, conserved site [IPR019897]", "S-adenosyl-L-homocysteine hydrolase, conserved site [IPR020082]", "S-adenosylmethionine synthetase, conserved site [IPR022631]", "S100/Calbindin-D9k, conserved site [IPR001751]", "SAICAR synthetase, conserved site [IPR018236]", "SecY conserved site [IPR030659]", "Serpin, conserved site [IPR023795]", "Short-chain dehydrogenase/reductase, conserved site [IPR020904]", "Sodium:dicarboxylate symporter, conserved site [IPR018107]", "Squalene/phytoene synthase, conserved site [IPR019845]", "Stathmin, conserved site [IPR030514]", "Sterol reductase, conserved site [IPR018083]", "Succinyl-CoA synthetase, beta subunit, conserved site [IPR017866]", "Sugar transporter, conserved site [IPR005829]", "Sulfatase, conserved site [IPR024607]", "Syntaxin/epimorphin, conserved site [IPR006012]", "TPP-binding enzyme, conserved site [IPR000399]", "Terpene synthase, conserved site [IPR002365]", "Tetrahydrofolate dehydrogenase/cyclohydrolase, conserved site [IPR020867]", "Tetraspanin, conserved site [IPR018503]", "Thiolase, conserved site [IPR020613]", "Thioredoxin, conserved site [IPR017937]", "Thiosulphate sulfurtransferase, conserved site [IPR001307]", "Thymidine kinase, conserved site [IPR020633]", "Thymidylate kinase, conserved site [IPR018095]", "Tr-type G domain, conserved site [IPR031157]", "Transcription factor TFIIB, conserved site [IPR023486]", "Translation elongation factor EF1B, beta/delta chains, conserved site [IPR001326]", "Translation elongation factor Ts, conserved site [IPR018101]", "Translationally controlled tumour protein, conserved site [IPR018103]", "Tubulin, conserved site [IPR017975]", "Ubiquitin conserved site [IPR019954]", "Ubiquitin interacting motif [IPR003903]", "Ubiquitin specific protease, conserved site [IPR018200]", "Ubiquitin-activating enzyme E1, conserved site [IPR018074]", "Vinculin, conserved site [IPR000633]", "WD40 repeat, conserved site [IPR019775]", "XPG conserved site [IPR019974]", "YgfZ/GcvT conserved site [IPR017703]", "Zinc finger, PHD-type, conserved site [IPR019786]", "Zinc finger, RING-type, conserved site [IPR017907]"], "available_proteins": ["AAAS", "ABCB1", "ABCB7", "ABCD3", "ABCE1", "ABCF1", "ABCF2", "ABCF3", "ACAA1", "ACAA2", "ACAD9", "ACADM", "ACADVL", "ACAT1", "ACAT2", "ACBD5", "ACIN1", "ACLY", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN4", "ACTR1A", "ACTR2", "ACTR3", "ADH5", "ADK", "ADSL", "AFG3L2", "AHCY", "AHCYL1", "AK1", "AK2", "AK3", "AK4", "AKR1A1", "AKR1B1", "ALDH18A1", "ALDH1A2", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ANXA1", "ANXA11", "ANXA2", "ANXA4", "ANXA6", "ANXA7", "AP1M1", "AP1S1", "AP2M1", "AP2S1", "AP3M1", "AP3S1", "APEX1", "APLP2", "APP", "ATAD1", "ATP5C1", "ATP5O", "ATP7A", "BAG6", "BAX", "BAZ1A", "BAZ1B", "BCAT2", "BCS1L", "BDH2", "BOP1", "BPNT1", "BRD2", "BRD4", "BUD31", "CAD", "CALR", "CANX", "CAP1", "CAP2", "CAPZA1", "CAPZA2", "CAPZB", "CBR1", "CBX1", "CBX3", "CBX5", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CDKAL1", "CETN2", "CHAF1B", "CHD1", "CHD4", "CLGN", "CMPK1", "CNDP2", "COPA", "COPZ1", "CORO1B", "CORO1C", "CPOX", "CSTB", "CSTF1", "CTBP1", "CTBP2", "CTNNA1", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CWC27", "CYP51A1", "DCAF7", "DCPS", "DCXR", "DDT", "DDX10", "DDX17", "DDX18", "DDX20", "DDX23", "DDX24", "DDX27", "DDX3X", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX51", "DDX54", "DDX6", "DHCR7", "DHFR", "DHRS4", "DHRS7", "DHRS7B", "DHX15", "DHX29", "DHX30", "DHX33", "DHX36", "DHX38", "DHX8", "DHX9", "DIDO1", "DIMT1", "DIS3", "DLG3", "DMD", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJB11", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC2", "DNAJC9", "DNM1L", "DNM2", "DNMT1", "DRG1", "DRG2", "DSG2", "DTYMK", "DYNLL1", "DYNLL2", "EARS2", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "EEF1A2", "EEF1B2", "EEF1D", "EEF2", "EIF3I", "EIF4A1", "EIF4A3", "EIF4E", "EIF4E2", "ENO1", "ENO2", "EPB41", "EPB41L2", "EPB41L5", "EPDR1", "EPRS", "ERCC2", "ETFA", "ETFB", "EXO1", "EZR", "FBL", "FDFT1", "FDPS", "FEN1", "FH", "FLNA", "FLNB", "FLNC", "FUCA1", "FUCA2", "GAA", "GALK1", "GALM", "GANAB", "GART", "GCDH", "GEMIN5", "GFM1", "GLA", "GLB1", "GLO1", "GNPDA1", "GNS", "GOLGA2", "GPI", "GPX8", "GRHPR", "GRWD1", "GSPT1", "GTF2B", "GUF1", "GUSB", "H2AFX", "H4C1*", "HADH", "HADHA", "HADHB", "HINT2", "HLA-A", "HLA-B", "HLA-F", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMOX1", "HMOX2", "HSD17B10", "HSD17B12", "HSD17B4", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA13", "HSPA14", "HSPA1B", "HSPA2", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPD1", "HSPE1", "HSPH1", "HYOU1", "IARS", "IARS2", "IBA57", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDH3G", "ILVBL", "IMMP2L", "IMPDH1", "IMPDH2", "INA", "IQGAP1", "IQGAP2", "IVD", "KDSR", "KIF11", "KIF14", "KIF23", "KIF2A", "KIF2C", "KIF4A", "KIF5B", "LAMP1", "LAMP2", "LARS", "LARS2", "LBR", "LIG3", "LMNA", "LMNB1", "LMNB2", "LRWD1", "LSS", "MACF1", "MAPK1", "MAPK14", "MAPK3", "MARS", "MAT2A", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "ME2", "MGST2", "MIF", "MOCS1", "MPI", "MPP1", "MPP2", "MPP6", "MPP7", "MPST", "MRPL24", "MRPL3", "MRPS11", "MRPS2", "MRPS5", "MRPS9", "MSN", "MTAP", "MTF2", "MTHFD1", "MTHFD1L", "MTHFD2", "MTOR", "ND1", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS8", "NDUFV1", "NEFL", "NEFM", "NES", "NKTR", "NLE1", "NMT1", "NNT", "NOP2", "NSD2", "NSF", "NUBP2", "NUDT1", "NUDT12", "NUDT5", "NUP153", "NUP37", "OSBP", "OSBPL11", "OSBPL8", "OSGEP", "P4HB", "PAFAH1B1", "PAICS", "PAK1IP1", "PBRM1", "PCK2", "PCNA", "PDIA3", "PDIA4", "PDIA6", "PEBP1", "PEPD", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGK1", "PGM1", "PGM2", "PGM3", "PHF3", "PHGDH", "PIK3C2A", "PIN1", "PLEC", "PLOD1", "PLOD2", "PLOD3", "PLRG1", "PLS3", "PNP", "PNPLA6", "POLA1", "POLD1", "POLR1B", "POLR1C", "POLR2B", "POLR2C", "POLR2E", "PPIB", "PPIC", "PPID", "PPIF", "PPIH", "PPIL1", "PPP2R2A", "PRKAR1A", "PRKAR2A", "PRKDC", "PRPF19", "PRPF4", "PSMA4", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD4", "PUS7", "PWP1", "PWP2", "PYGB", "PYGL", "QARS", "RACK1", "RAE1", "RANBP2", "RARS", "RBBP7", "RCL1", "RDH13", "RDX", "REL", "RIDA", "RNF20", "RNF40", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL15", "RPL17", "RPL18", "RPL19", "RPL21", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL37", "RPL4", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPS11", "RPS14", "RPS15", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS24", "RPS28", "RPS29", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS8", "RPS9", "RPSA", "RSF1", "RTCA", "RTN4IP1", "S100A10", "S100A11", "SART1", "SBDS", "SCD", "SCP2", "SDHB", "SEC11A", "SEC61A1", "SERPINB6", "SERPINH1", "SLC1A5", "SLC25A42", "SLC27A4", "SLC2A1", "SLIT2", "SMARCA4", "SMS", "SMU1", "SNRNP40", "SORD", "SPTBN1", "SRCAP", "SRM", "STAM", "STMN1", "STRN", "STX12", "STX16", "STX18", "STX4", "STX5", "STX7", "SUCLA2", "SUCLG1", "SUCLG2", "TAP1", "TBL3", "TCP1", "THOC6", "TK1", "TLN1", "TM7SF2", "TMBIM6", "TMX1", "TMX3", "TMX4", "TOP2A", "TOP2B", "TPT1", "TRIM25", "TRIM28", "TRIP13", "TRMT11", "TSFM", "TSPAN3", "TSPAN6", "TUBB", "TUBB2A", "TUBB2B", "TUBB4A", "TUBB4B", "TUBB6", "TUFM", "TXN2", "TXNDC12", "TXNDC5", "TXNL1", "UBA1", "UBA2", "UBA5", "UBFD1", "UHRF1", "USP10", "USP14", "USP28", "USP47", "USP48", "USP5", "USP7", "USP9X", "UTP15", "UTP18", "UTRN", "VARS1", "VARS2", "VAT1", "VCL", "VCP", "VIM", "VPS4A", "WARS", "WARS2", "WDHD1", "WDR1", "WDR12", "WDR18", "WDR3", "WDR36", "WDR5", "WDR61", "XPNPEP1", "YARS2", "YME1L1", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2"], "leading_proteins": ["ALDH1A2", "ALDH1B1", "ALDH2", "ALDH3A2", "AP1M1", "APLP2", "CANX", "CAP2", "CTBP1", "DHRS7", "DNAJC11", "DNM1L", "EEF1B2", "EIF4E", "GAA", "HADH", "HMOX2", "HSP90AA1", "HSP90B1", "IMPDH1", "INA", "KDSR", "LBR", "MCM2", "MCM4", "MCM5", "MCM6", "MCM7", "NES", "P4HB", "PHGDH", "PLOD1", "PLOD3", "POLR1C", "PRKAR1A", "PSMB2", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "RDH13", "SRM", "STX18", "STX5", "STX7", "TMX1", "TMX3", "TMX4", "TSPAN3", "VAT1", "VIM", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAZ", "ZADH2"]}

interpro_domain/advanced/idx2term.json

@@ -0,0 +1 @@
+{"0": "Thioredoxin domain [IPR013766]"}

interpro_domain/basic/idx2term.json

@@ -0,0 +1 @@
+{"0": "Thioredoxin domain [IPR013766]", "1": "Band 7 domain [IPR001107]", "2": "EF-hand domain [IPR002048]", "3": "Target SNARE coiled-coil homology domain [IPR000727]", "4": "CBS domain [IPR000644]", "5": "FKBP-type peptidyl-prolyl cis-trans isomerase domain [IPR001179]", "6": "Proteasome component (PCI) domain [IPR000717]", "7": "MCM, AAA-lid domain [IPR041562]", "8": "MCM OB domain [IPR033762]", "9": "MCM domain [IPR001208]", "10": "MCM N-terminal domain [IPR027925]", "11": "14-3-3 domain [IPR023410]", "12": "K Homology domain, type 1 [IPR004088]"}

interpro_domain/consensus.joblib

@@ -0,0 +1,3 @@
+version https://git-lfs.github.com/spec/v1
+oid sha256:1be5b1164c954a05cecc66806186507706433abf43caf07b7d4bd7257325a70d
+size 181239

interpro_domain/df_merge.tsv

@@ -0,0 +1,3 @@
+term	overlap	setsize	score	pval	overlap_mean	setsize_mean	score_mean	pval_mean	overlap_std	setsize_std	score_std	pval_std	pval_hit	pval_50	pval_100	pval_250	pval_500
+Cytochrome b5-like heme/steroid binding domain [IPR001199]	4	6	2.3288841414688	0.0198652042790434	2.813106796116505	6.104368932038835	1.6405397264547834	0.1100883340733615	1.2852875686886795	0.8042848477475721	1.100790504333474	0.1612592696854457	8.638915621057674e-05	0.0573151884822011	0.0001778916397324	5.306786809041431e-06	0.0001560226497295
+Thioredoxin domain [IPR013766]	9	25	2.109422224124922	0.0349081528504164	7.337378640776699	24.466019417475728	0.0844234219349461	0.6437385081192002	3.698630148194872	1.9033212360971283	0.7768025655466331	0.3030457631637904	0.1552961491760764	1.0	1.0	0.0440381918347023	2.197530726520649e-06

interpro_domain/metrics.json

@@ -0,0 +1,7 @@
+{
+    "type_of_task": "ranksum",
+    "signature_size": 2813,
+    "annotations_size": 2301,
+    "title": "Average number of proteins per term",
+    "value": 2.060408518035637
+}

interpro_domain/paths.json

@@ -0,0 +1 @@
+{"results_path": "results/proteins/hek293t_core/interpro_domain/fragment/C234/C234_val_log2fc"}

interpro_domain/result.tsv

@@ -0,0 +1,175 @@
+Term	es	nes	pval	sidak	fdr	geneset_size	leading_edge	leading_edge_size
+Cytochrome b5-like heme/steroid binding domain [IPR001199]	0.8770149406194317	2.3288841414688	0.0198652042790434	1.0	0.3578055326216351	6	Q9UMX5,O43169,O00264,O15173	4
+Thioredoxin domain [IPR013766]	0.5647359844100194	2.109422224124922	0.0349081528504164	1.0	0.3595402778895175	25	O43819,Q6ZRP7,P07237,Q96JJ7,O95881,Q96J42,Q9H3N1,Q9H1E5,O14530	9
+Peptidase M16, C-terminal [IPR007863]	0.698785783869839	1.7841523595841349	0.0743989111331167	1.0	0.4145082191702215	7	Q10713,Q5JRX3,P31930	3
+Peptidase M16, N-terminal [IPR011765]	0.698785783869839	1.7841523595841349	0.0743989111331167	1.0	0.4145082191702215	7	Q10713,Q5JRX3,P31930	3
+Intermediate filament head, DNA-binding domain [IPR006821]	0.8686307336270027	1.758955826463284	0.0785850117879745	1.0	0.4234756724218485	4	Q16352,P08670	2
+Intermediate filament, rod domain [IPR039008]	0.675135848313019	1.7453840988251013	0.0809180316913347	1.0	0.4310009049114842	8	Q16352,P48681,P08670	3
+GMP phosphodiesterase, delta subunit [IPR008015]	0.9743772241992872	1.7424960772188829	0.0814216772796023	1.0	0.4326819386151617	3	Q13432,O43924	2
+Reticulon [IPR003388]	0.856960532838625	1.7139672320495498	0.0865347440759598	1.0	0.4454506624581288	4	Q9NQC3,O95197	2
+Band 7 domain [IPR001107]	0.6817948310881893	1.7026199150335473	0.0886392207007329	1.0	0.4487874808676769	7	P35232,Q14254,Q9UJZ1,Q99623,O75955	5
+EF-hand domain [IPR002048]	0.48738955282938	1.689507874800084	0.0911221440420051	1.0	0.4487874808676769	41	O75340,P80303,Q9BRK5,O95202,O43852,Q9NWM8,Q9Y680,Q9BPX6,Q66K14,Q9UBC2,P41208,Q96D71,Q14257,Q8IYU8,Q6NUK1,Q96AY3,Q9UJS0	17
+Tim10-like [IPR004217]	0.8225599057100768	1.580512821561188	0.1139894729857236	1.0	0.4954731434989012	4	Q9Y5J9,P62072	2
+TRAM/LAG1/CLN8 homology domain [IPR006634]	0.8212887148451548	1.5755593709242477	0.1151273857121388	1.0	0.4954731434989012	4	Q15629,Q96G23,Q8N5B7	3
+ERAP1-like C-terminal domain [IPR024571]	0.9156583629893276	1.521980465074282	0.1280139755512561	1.0	0.4958925214536033	3	P55786,Q9UIQ6	2
+Endoplasmic reticulum vesicle transporter, N-terminal [IPR039542]	0.912471639912008	1.509960244889754	0.1310535686308451	1.0	0.4986481742613161	3	Q9Y282	1
+Endoplasmic reticulum vesicle transporter, C-terminal [IPR012936]	0.912471639912008	1.509960244889754	0.1310535686308451	1.0	0.4986481742613161	3	Q9Y282	1
+GOLD domain [IPR009038]	0.7349260985463317	1.4619192119570017	0.1437633496232191	1.0	0.5136637693835826	5	Q9Y3A6,P49755,Q9Y3B3	3
+HDGF-related, PWWP domain [IPR035496]	0.7797509058326171	1.413002702553312	0.1576549294723292	1.0	0.527431126524162	4	Q7Z4V5	1
+LEM domain [IPR003887]	0.662176343653891	1.3851229789278003	0.1660148666146208	1.0	0.5488139969979092	6	Q86XL3,P42167	2
+Peptidase M1, membrane alanine aminopeptidase [IPR014782]	0.6877730105280526	1.2624346733904004	0.206792419148454	1.0	0.6101882284463112	5	P55786,Q9UIQ6	2
+Aminopeptidase N-like , N-terminal domain [IPR045357]	0.6877730105280526	1.2624346733904004	0.206792419148454	1.0	0.6101882284463112	5	P55786,Q9UIQ6	2
+Phospholipase D/Transphosphatidylase [IPR001736]	0.9580220562077552	1.1844920356021678	0.2362183471443153	1.0	0.6463001388573955	2	Q8N2A8	1
+Homeobox domain [IPR001356]	0.8186389881932149	1.1557772051021755	0.2477722991956943	1.0	0.6606304292575813	3	Q96G23	1
+ABC1 atypical kinase-like domain [IPR004147]	0.949128424048383	1.1519630909890264	0.2493362405047543	1.0	0.6624973318723322	2	Q8NI60	1
+ADCK3-like domain [IPR034646]	0.949128424048383	1.1519630909890264	0.2493362405047543	1.0	0.6624973318723322	2	Q8NI60	1
+Target SNARE coiled-coil homology domain [IPR000727]	0.5670173299950685	1.139058713562847	0.254678666141956	1.0	0.6644167922819056	7	O15400,Q12846,Q8IZP0,Q13190,Q9UNK0	5
+CBS domain [IPR000644]	0.5499395653335525	1.0542397683571063	0.2917731569805022	1.0	0.6993518381029459	7	P51790,P51798,P20839,Q6P4Q7,Q8NE01	5
+NOPS [IPR012975]	0.7772241992882616	1.001056372407634	0.3167995554898049	1.0	0.7171172854135474	3	Q15233,P23246	2
+Acyl-CoA oxidase, C-terminal [IPR002655]	0.89007470651014	0.9390887353727256	0.3476851873028459	1.0	0.7527764506944893	2	Q15067	1
+Metaxin, glutathione S-transferase domain [IPR033468]	0.8861615083600176	0.9252350136732054	0.3548436741918261	1.0	0.7630605961650482	2	Q13505	1
+Mitochondrial outer membrane transport complex Sam37/metaxin, N-terminal domain [IPR019564]	0.8861615083600176	0.9252350136732054	0.3548436741918261	1.0	0.7630605961650482	2	Q13505	1
+Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase, N-terminal [IPR018955]	0.8858057630736393	0.9239775076278272	0.3554980265488621	1.0	0.7630605961650482	2	Q15118	1
+Histidine kinase domain [IPR005467]	0.8858057630736393	0.9239775076278272	0.3554980265488621	1.0	0.7630605961650482	2	Q15118	1
+Cyclic nucleotide-binding domain [IPR000595]	0.6532573869704674	0.9168386247001612	0.359227209381955	1.0	0.7646455215429034	4	Q8IY17,Q6P4Q7,P10644	3
+ATPase family AAA domain-containing protein 3, N-terminal [IPR021911]	0.8783351120597662	0.8976468148351571	0.3693738722955497	1.0	0.7769006217112066	2	Q9NVI7	1
+ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domain [IPR000194]	0.6336053691710579	0.841233168218653	0.400217322525467	1.0	0.8193708172807513	4	P21281	1
+ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain [IPR004100]	0.6336053691710579	0.841233168218653	0.400217322525467	1.0	0.8193708172807513	4	P21281	1
+BRICHOS domain [IPR007084]	0.8545001778726469	0.8147255126712578	0.4152294463053914	1.0	0.8286582445348704	2	Q9Y287	1
+Major facilitator superfamily domain [IPR020846]	0.5351591919774441	0.8049481246297332	0.4208496157683719	1.0	0.8292615567691842	6	Q6NT16,Q8NHS3	2
+Zinc finger, CHHC-type [IPR012996]	0.721352313167255	0.7972583610344299	0.4253009977386881	1.0	0.8307449879428873	3	P31943,P55795	2
+FKBP-type peptidyl-prolyl cis-trans isomerase domain [IPR001179]	0.4543990665364505	0.7931435128735118	0.4276942137131039	1.0	0.8332585295216036	11	Q9NWM8,Q9Y680,Q02790,Q13451,Q96AY3,P62942	6
+Alpha/beta hydrolase fold-1 [IPR000073]	0.4793356528384362	0.750679298107493	0.4528456848109556	1.0	0.8478420836045638	8	P07099	1
+Proteasome component (PCI) domain [IPR000717]	0.4117486987459616	0.7186509053201446	0.4723560398531807	1.0	0.866739431979401	16	Q9BT78,O00231,Q99627,Q9UNS2,P61201,Q9UBW8	6
+Marvel domain [IPR008253]	0.8192813945215276	0.6958918220338202	0.4864965791747933	1.0	0.8677047281400017	2	O43760	1
+Oxoglutarate/iron-dependent dioxygenase [IPR005123]	0.5092589984067819	0.6898442093934599	0.4902921636112602	1.0	0.8702664983044988	6	Q02809,P13674	2
+Prolyl 4-hydroxylase, alpha subunit [IPR006620]	0.5092589984067819	0.6898442093934599	0.4902921636112602	1.0	0.8702664983044988	6	Q02809,P13674	2
+Peptidase M3A/M3B catalytic domain [IPR001567]	0.6894231478041347	0.6850281204666095	0.4933261763206564	1.0	0.8730223368020218	3	Q9BYT8	1
+FAD linked oxidase, N-terminal [IPR006094]	0.813589469939528	0.6771783415408915	0.4982928077742179	1.0	0.8773657231816218	2	Q15392	1
+FAD-binding domain, PCMH-type [IPR016166]	0.813589469939528	0.6771783415408915	0.4982928077742179	1.0	0.8773657231816218	2	Q15392	1
+RBM3/CIRBP, RNA recognition motif [IPR034278]	0.8078975453575269	0.6586186725006135	0.5101406692460948	1.0	0.8792303463102671	2	P98179	1
+W2 domain [IPR003307]	0.4669274735295773	0.6483970569849986	0.5167281733361939	1.0	0.8792303463102671	7	P55010,Q13144	2
+Chromo shadow domain [IPR008251]	0.6772241992882594	0.643270040995286	0.5200488923634392	1.0	0.8792303463102671	3	P83916,P45973	2
+Chromo domain subgroup [IPR017984]	0.6772241992882594	0.643270040995286	0.5200488923634392	1.0	0.8792303463102671	3	P83916,P45973	2
+SUN coiled coil domain 2 [IPR040994]	0.798292422625404	0.6276661708394524	0.5302226508993519	1.0	0.8815944539728096	2	O94901	1
+Tim44-like domain [IPR007379]	0.795802205620781	0.6197198825235125	0.5354422233116671	1.0	0.8857315282819167	2	O43615	1
+Major sperm protein (MSP) domain [IPR000535]	0.6688949229952853	0.6151729353719547	0.5384405193270783	1.0	0.8881373727395032	3	O95292	1
+Dynamin-type guanine nucleotide-binding (G) domain [IPR030381]	0.4562080895694175	0.597862828805739	0.5499314640525086	1.0	0.8935211993580956	7	Q8IWA4,O60313	2
+Dynamin, N-terminal [IPR045063]	0.4562080895694175	0.597862828805739	0.5499314640525086	1.0	0.8935211993580956	7	Q8IWA4,O60313	2
+Dynamin, GTPase domain [IPR001401]	0.6619195122475324	0.5919222515992902	0.5539026525977444	1.0	0.8935211993580956	3	O60313	1
+Peptidase S9A, N-terminal domain [IPR023302]	0.7851298470295323	0.5860497402387347	0.5578420896355314	1.0	0.8935211993580956	2	Q4J6C6	1
+LEM-like domain [IPR013146]	0.7847741017431578	0.584938494373452	0.5585890738095691	1.0	0.8935211993580956	2	P42167	1
+START domain [IPR002913]	0.7815723941657811	0.5749705010632595	0.5653112475870214	1.0	0.8935211993580956	2	Q14849	1
+EH domain [IPR000261]	0.5514803874975663	0.5393479906726597	0.5896467606725273	1.0	0.9051215452351468	4	Q96D71	1
+SUN domain [IPR012919]	0.6420655098213583	0.5272749230549189	0.5980026859519434	1.0	0.9058876776884164	3	O94901	1
+CELF1/2, RNA recognition motif 3 [IPR034199]	0.7520455353966604	0.4860663960516286	0.6269200914112016	1.0	0.9162592659143364	2	O95319	1
+CELF1/2, RNA recognition motif 2 [IPR034198]	0.7520455353966604	0.4860663960516286	0.6269200914112016	1.0	0.9162592659143364	2	O95319	1
+CELF1/2, RNA recognition motif 1 [IPR034196]	0.7520455353966604	0.4860663960516286	0.6269200914112016	1.0	0.9162592659143364	2	O95319	1
+3-hydroxyacyl-CoA dehydrogenase, NAD binding [IPR006176]	0.7506225542511606	0.4819293503346813	0.6298561353284087	1.0	0.9162592659143364	2	Q16836	1
+3-hydroxyacyl-CoA dehydrogenase, C-terminal [IPR006108]	0.7506225542511606	0.4819293503346813	0.6298561353284087	1.0	0.9162592659143364	2	Q16836	1
+Amyloidogenic glycoprotein, copper-binding [IPR011178]	0.7499110636784108	0.4798662263046584	0.6313225178864823	1.0	0.9162592659143364	2	Q06481	1
+Pancreatic trypsin inhibitor Kunitz domain [IPR002223]	0.7499110636784108	0.4798662263046584	0.6313225178864823	1.0	0.9162592659143364	2	Q06481	1
+Beta-amyloid precursor protein C-terminal [IPR019543]	0.7499110636784108	0.4798662263046584	0.6313225178864823	1.0	0.9162592659143364	2	Q06481	1
+Amyloidogenic glycoprotein, heparin-binding [IPR015849]	0.7499110636784108	0.4798662263046584	0.6313225178864823	1.0	0.9162592659143364	2	Q06481	1
+Amyloidogenic glycoprotein, extracellular [IPR008154]	0.7499110636784108	0.4798662263046584	0.6313225178864823	1.0	0.9162592659143364	2	Q06481	1
+Amyloidogenic glycoprotein, E2 domain [IPR024329]	0.7499110636784108	0.4798662263046584	0.6313225178864823	1.0	0.9162592659143364	2	Q06481	1
+Acyl-CoA oxidase/dehydrogenase, central domain [IPR006091]	0.42818027969537	0.4695363024876719	0.6386863426453577	1.0	0.9231264286601558	7	P49748,Q15067	2
+Aldehyde dehydrogenase domain [IPR015590]	0.4108419511735049	0.4573566398869887	0.6474147248561204	1.0	0.9239265307950842	9	O94788,P51648	2
+CARG-binding factor, N-terminal [IPR012956]	0.7371042333689128	0.4433623185012209	0.657503686747315	1.0	0.9268766431720584	2	Q99729	1
+G-protein gamma-like domain [IPR015898]	0.7356812522234144	0.4393822515843249	0.6603845846039607	1.0	0.9268766431720584	2	P63218	1
+MCM, AAA-lid domain [IPR041562]	0.4495903099394264	0.4384194900829644	0.6610822205140932	1.0	0.9268766431720584	6	P33993,Q14566,P33992,P33991,P49736	5
+MCM OB domain [IPR033762]	0.4495903099394264	0.4384194900829644	0.6610822205140932	1.0	0.9268766431720584	6	P33993,Q14566,P33992,P33991,P49736	5
+MCM domain [IPR001208]	0.4495903099394264	0.4384194900829644	0.6610822205140932	1.0	0.9268766431720584	6	P33993,Q14566,P33992,P33991,P49736	5
+MCM N-terminal domain [IPR027925]	0.4495903099394264	0.4384194900829644	0.6610822205140932	1.0	0.9268766431720584	6	P33993,Q14566,P33992,P33991,P49736	5
+P-type ATPase, haloacid dehalogenase domain [IPR044492]	0.4166422087632857	0.4187065029008821	0.675430642570426	1.0	0.9268766431720584	7	Q9HD20,P16615	2
+CNNM, transmembrane domain [IPR002550]	0.7164710067591662	0.387222772155509	0.6985912928919389	1.0	0.9354961616275118	2	Q6P4Q7	1
+Ion transporter-like, CBS domain [IPR044751]	0.7164710067591662	0.387222772155509	0.6985912928919389	1.0	0.9354961616275118	2	Q6P4Q7	1
+Far upstream element-binding protein, C-terminal [IPR015096]	0.7061543934542929	0.3604780668453248	0.7184896558131157	1.0	0.9399578036962022	2	Q96AE4	1
+14-3-3 domain [IPR023410]	0.4271464196651119	0.3514973064850355	0.7252152928487474	1.0	0.9399578036962022	6	P62258,Q04917,P61981,P31946,P63104	5
+Proteasome activator PA28, N-terminal domain [IPR003185]	0.5720280744708609	0.3220423549618236	0.7474206076929795	1.0	0.9413326865361498	3	Q9UL46	1
+Proteasome activator PA28, C-terminal domain [IPR003186]	0.5720280744708609	0.3220423549618236	0.7474206076929795	1.0	0.9413326865361498	3	Q9UL46	1
+Immunoglobulin-like domain [IPR007110]	0.3800482899708595	0.316705856211096	0.7514668047649358	1.0	0.9428295834925616	9	P35613	1
+Glycosyl transferase CAP10 domain [IPR006598]	0.686944147990046	0.3132023370383612	0.754126942991773	1.0	0.944400517633414	2	Q8NBL1	1
+Alcohol dehydrogenase, N-terminal [IPR013154]	0.43839768982531	0.2800571451318774	0.779433662774873	1.0	0.9522844793739152	5	Q8N4Q0,Q99536	2
+PIH1D1/2/3, CS-like domain [IPR041442]	0.6670224119530492	0.267854852864083	0.7888110463653553	1.0	0.9522844793739152	2	Q9NVR5	1
+PIH1, N-terminal [IPR012981]	0.6670224119530492	0.267854852864083	0.7888110463653553	1.0	0.9522844793739152	2	Q9NVR5	1
+Serine-threonine/tyrosine-protein kinase, catalytic domain [IPR001245]	0.4284216226992727	0.2496437676335295	0.8028628482924554	1.0	0.9585462965372148	5	Q13546	1
+cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain [IPR003117]	0.6527926004980515	0.2378789080603779	0.8119750149337897	1.0	0.9605935780784832	2	P10644	1
+Septin-type guanine nucleotide-binding (G) domain [IPR030379]	0.4223277821468316	0.2317016077020641	0.8167697825972942	1.0	0.9613856681647256	5	Q16181	1
+Polyketide synthase, enoylreductase domain [IPR020843]	0.3925321187080923	0.2293162505869653	0.8186231238388091	1.0	0.9619323243669295	6	Q8N4Q0,Q99536	2
+ENTH  domain [IPR013809]	0.5306049822063972	0.2220907257491185	0.824243257371128	1.0	0.962454916931014	3	Q13492,Q14677	2
+Heat shock chaperonin-binding [IPR006636]	0.4138176638176588	0.2074888109473739	0.835628130114378	1.0	0.9626489870698072	5	P31948,Q9UHD9,Q9NRR5,Q9BSL1	4
+Ribosomal protein S10 domain [IPR027486]	0.6335823550338047	0.2007274100954673	0.8409117257453664	1.0	0.9626489870698072	2	P60866	1
+Heterogeneous nuclear ribonucleoprotein Q acidic domain [IPR041337]	0.618996798292432	0.1751202193713774	0.860985171003029	1.0	0.9626489870698072	2	O60506	1
+Dynamin GTPase effector [IPR003130]	0.6168623265741824	0.1715627983267192	0.8637812563630356	1.0	0.9626489870698072	2	O00429	1
+GTPase effector domain [IPR020850]	0.6168623265741824	0.1715627983267192	0.8637812563630356	1.0	0.9626489870698072	2	O00429	1
+Dynamin stalk domain [IPR000375]	0.6168623265741824	0.1715627983267192	0.8637812563630356	1.0	0.9626489870698072	2	O00429	1
+Arf GTPase activating protein [IPR001164]	0.6047669868374344	0.152321507701264	0.8789333621587843	1.0	0.966280777031707	2	Q8N6T3	1
+Syntaxin, N-terminal domain [IPR006011]	0.4127471226705427	0.1435912954796771	0.8858232146233567	1.0	0.9713686311542704	4	O15400,Q12846	2
+Sorting nexin Vps5-like, C-terminal [IPR015404]	0.411890352438594	0.1418404005434375	0.8872060716455017	1.0	0.9716608116049904	4	Q9UNH7,Q9Y5X3,O60749	3
+Ribosomal protein S7 domain [IPR023798]	0.5912486659551865	0.1326550108623213	0.8944662244446426	1.0	0.9735498379987056	2	P46782	1
+Nuclear transport factor 2, eukaryote [IPR018222]	0.4038218252184717	0.1258454251161897	0.899854283538605	1.0	0.9748421405001554	4	Q9UN86	1
+Nuclear transport factor 2 domain [IPR002075]	0.4038218252184717	0.1258454251161897	0.899854283538605	1.0	0.9748421405001554	4	Q9UN86	1
+Isopenicillin N synthase-like, Fe(2+) 2OG dioxygenase domain [IPR044861]	0.4772241992882466	0.1219128337451116	0.9029680515873452	1.0	0.9764889174108956	3	Q02809,O60568	2
+Thioredoxin-like fold [IPR012336]	0.582355033795813	0.1207636349281186	0.9038782543649944	1.0	0.9764889174108956	2	Q6DKJ4	1
+BAT2, N-terminal [IPR009738]	0.4733096085409171	0.1159014717905428	0.9077306292387636	1.0	0.976901695989206	3	Q9Y520,Q5JSZ5	2
+Heat shock protein Hsp90, N-terminal [IPR020575]	0.3980064079743682	0.1148742506287973	0.9085447949801956	1.0	0.976901695989206	4	P08238,P14625,P07900	3
+Cation-transporting P-type ATPase, C-terminal [IPR006068]	0.3767151991095614	0.1143342266836794	0.9089728514180312	1.0	0.976901695989206	5	P16615	1
+Cation-transporting P-type ATPase, N-terminal [IPR004014]	0.3767151991095614	0.1143342266836794	0.9089728514180312	1.0	0.976901695989206	5	P16615	1
+K Homology domain, type 1 [IPR004088]	0.2916531156726914	0.1125336129964251	0.9104003196829578	1.0	0.9774945114647956	21	Q9Y2W6,P61978,Q96AE4,Q96PU8,Q15365,Q9UNW9,Q96I24,Q92945,Q92667,Q13868	10
+Peptidase M20, dimerisation domain [IPR011650]	0.5642120241906909	0.099024276595795	0.9211189948974314	1.0	0.9819377543066689	2	Q8IYS1	1
+Glutamine amidotransferase type 2 domain [IPR017932]	0.4580071174377222	0.0941483552537543	0.924991308999818	1.0	0.9853726861150836	3	P08243,Q06210	2
+NET domain [IPR027353]	0.5496264674493182	0.0839153505266927	0.9331237346537836	1.0	0.9889994073875432	2	O60885	1
+Brdt, bromodomain, repeat II [IPR043509]	0.5496264674493182	0.0839153505266927	0.9331237346537836	1.0	0.9889994073875432	2	O60885	1
+Brdt, bromodomain, repeat I [IPR043508]	0.5496264674493182	0.0839153505266927	0.9331237346537836	1.0	0.9889994073875432	2	O60885	1
+Tudor domain [IPR002999]	0.3210484320209442	0.0793424979156133	0.936760204378347	1.0	0.990786148716564	8	Q14739	1
+GINS subunit, domain A [IPR021151]	0.4444839857651183	0.0772009724186469	0.9384636680791631	1.0	0.990786148716564	3	Q9BRX5,Q9BRT9	2
+Elongation factor 1 beta central acidic region, eukaryote [IPR018940]	0.5400213447171949	0.0750654503809033	0.9401626368412396	1.0	0.990786148716564	2	P24534	1
+Translation elongation factor EF1B, beta/delta subunit, guanine nucleotide exchange domain [IPR014038]	0.5400213447171949	0.0750654503809033	0.9401626368412396	1.0	0.990786148716564	2	P24534	1
+Spermidine synthase, tetramerisation domain [IPR035246]	0.539309854144445	0.0744435067681851	0.9406574914249513	1.0	0.990786148716564	2	P19623	1
+Polyamine biosynthesis  domain [IPR030374]	0.539309854144445	0.0744435067681851	0.9406574914249513	1.0	0.990786148716564	2	P19623	1
+Adenylate cyclase-associated CAP, C-terminal [IPR013912]	0.5318392031305711	0.0681854954174492	0.9456379730782212	1.0	0.9922083794131268	2	P40123	1
+Adenylate cyclase-associated CAP, N-terminal [IPR013992]	0.5318392031305711	0.0681854954174492	0.9456379730782212	1.0	0.9922083794131268	2	P40123	1
+C-CAP/cofactor C-like domain [IPR017901]	0.5318392031305711	0.0681854954174492	0.9456379730782212	1.0	0.9922083794131268	2	P40123	1
+CARP motif [IPR006599]	0.5318392031305711	0.0681854954174492	0.9456379730782212	1.0	0.9922083794131268	2	P40123	1
+AP180 N-terminal homology (ANTH) domain [IPR011417]	0.530416221985071	0.067049017100101	0.9465426809624882	1.0	0.9927049721488994	2	Q13492	1
+PSP, proline-rich [IPR006568]	0.5243685521166974	0.0624121876549921	0.9502345895372124	1.0	0.9944141200831372	2	Q13435	1
+Glycoside hydrolase family 31, N-terminal domain [IPR025887]	0.5233013162575726	0.0616258973192325	0.9508607530559432	1.0	0.9944141200831372	2	P10253	1
+EF hand associated, type-1 [IPR013566]	0.5204553539665729	0.0595751488008384	0.9524940115876726	1.0	0.9944141200831372	2	Q8IXI2	1
+MIRO domain [IPR020860]	0.5204553539665729	0.0595751488008384	0.9524940115876726	1.0	0.9944141200831372	2	Q8IXI2	1
+EF hand associated, type-2 [IPR013567]	0.5204553539665729	0.0595751488008384	0.9524940115876726	1.0	0.9944141200831372	2	Q8IXI2	1
+BAR domain [IPR004148]	0.5186766275346969	0.0583270531043866	0.9534881189312594	1.0	0.994773180670187	2	Q9Y371	1
+Ras GTPase-activating domain [IPR001936]	0.4256227758007063	0.0569953335587171	0.954548912381156	1.0	0.9952048243720164	3	Q13576,Q14C86	2
+PA domain [IPR003137]	0.4873710423336985	0.0402815906465529	0.9678686304018616	1.0	0.998943313805312	2	Q8TCT8	1
+MRG domain [IPR026541]	0.4848808253290783	0.0391386724478605	0.9687798284224114	1.0	0.998943313805312	2	Q9UBU8	1
+Zinc finger, TFIIB-type [IPR013137]	0.4799003913198257	0.0369692509520456	0.9705095231584088	1.0	0.998943313805312	2	P29083	1
+DNA-directed RNA polymerase, RpoA/D/Rpb3-type [IPR011263]	0.4781216648879549	0.0362310657918566	0.971098115324655	1.0	0.998943313805312	2	O15160	1
+DNA-directed RNA polymerase, insert domain [IPR011262]	0.4781216648879549	0.0362310657918566	0.971098115324655	1.0	0.998943313805312	2	O15160	1
+Ancestral coatomer element 1, Sec16/Sec31 [IPR024298]	0.4763429384560803	0.0355116577268703	0.9716717507175244	1.0	0.998943313805312	2	O94979	1
+GYF domain [IPR003169]	0.4756314478833262	0.0352290834497803	0.9718970713804682	1.0	0.998943313805312	2	Q6Y7W6	1
+Sec23, C-terminal [IPR037550]	0.436855211668454	0.0237479783710962	0.9810536355765568	1.0	0.998943313805312	2	Q15437	1
+IMP dehydrogenase/GMP reductase [IPR001093]	0.4283173247954559	0.0220860653701082	0.982379301989913	1.0	0.998943313805312	2	P20839	1
+Transcription factor CBF/NF-Y/archaeal histone domain [IPR003958]	0.4208466737815875	0.0208346676908311	0.9833775429174464	1.0	0.998943313805312	2	Q9NR33	1
+Sorting nexin, N-terminal [IPR005329]	0.4115972963358321	0.0195183555488845	0.9844275942216124	1.0	0.998943313805312	2	O60749	1
+BURAN domain [IPR045354]	0.4101743151903366	0.0193367696343312	0.9845724514797642	1.0	0.998943313805312	2	Q8N163	1
+S1-like RNA binding domain [IPR025223]	0.4101743151903366	0.0193367696343312	0.9845724514797642	1.0	0.998943313805312	2	Q8N163	1
+LAIKA domain [IPR045353]	0.4101743151903366	0.0193367696343312	0.9845724514797642	1.0	0.998943313805312	2	Q8N163	1
+DBC1/CARP1 catalytically inactive NUDIX hydrolase domain [IPR025954]	0.4101743151903366	0.0193367696343312	0.9845724514797642	1.0	0.998943313805312	2	Q8N163	1
+Survival motor neuron [IPR010304]	0.4048381358947093	0.0187015975265342	0.985079153836668	1.0	0.998943313805312	2	Q16637	1
+Peptidyl-prolyl cis-trans isomerase, PpiC-type [IPR000297]	0.3824261828530886	0.0167102884931387	0.9866677392771576	1.0	0.998943313805312	2	Q13526	1
+Zinc finger, C3HC4 RING-type [IPR018957]	0.3703308431163377	0.0159965474282598	0.987237146096609	1.0	0.998943313805312	2	O75150	1
+RNA-binding S4 domain [IPR002942]	0.3654804270462713	0.0158708136592654	0.9873374543955422	1.0	0.998943313805312	3	Q9NV31,P46781	2
+CTP synthase GATase domain [IPR033828]	0.362148701529714	0.0156227515328533	0.9875353547984912	1.0	0.998943313805312	2	P17812	1
+CTP synthase, N-terminal [IPR017456]	0.362148701529714	0.0156227515328533	0.9875353547984912	1.0	0.998943313805312	2	P17812	1
+Extended synaptotagmin, C-terminal C2 domain [IPR037752]	0.3500533617929715	0.0151992155565975	0.987873247485494	1.0	0.998943313805312	2	A0FGR8	1
+Extended synaptotagmin, C2B domain [IPR037749]	0.3500533617929715	0.0151992155565975	0.987873247485494	1.0	0.998943313805312	2	A0FGR8	1
+Synaptotagmin-like mitochondrial-lipid-binding domain [IPR031468]	0.3500533617929715	0.0151992155565975	0.987873247485494	1.0	0.998943313805312	2	A0FGR8	1
+Extended synaptotagmin, C2A domain [IPR037733]	0.3500533617929715	0.0151992155565975	0.987873247485494	1.0	0.998943313805312	2	A0FGR8	1
+Synaptotagmin, SMP domain [IPR039010]	0.3500533617929715	0.0151992155565975	0.987873247485494	1.0	0.998943313805312	2	A0FGR8	1
+NudC N-terminal domain [IPR025934]	0.3390252579153428	0.0149197642518967	0.988096192084246	1.0	0.998943313805312	2	Q9Y266	1
+SPRY-associated [IPR006574]	0.3283528993240945	0.0147236291547557	0.9882526680613596	1.0	0.998943313805312	2	Q12899	1
+Butyrophylin-like, SPRY domain [IPR003879]	0.3283528993240945	0.0147236291547557	0.9882526680613596	1.0	0.998943313805312	2	Q12899	1
+Thioesterase domain [IPR006683]	0.3055852009960982	0.0144738921033654	0.98845190816587	1.0	0.998943313805312	2	Q9NPJ3	1
+Methyltransferase type 11 [IPR013216]	0.3576512455516043	0.0126722637149967	0.9898892670395842	1.0	0.9994450212628712	3	Q6FI81,Q6UX53	2
+CSN8/PSMD8/EIF3K [IPR033464]	0.346263345195735	0.0087140078066116	0.9930473156992764	1.0	1.0	3	Q99627,Q9UBQ5	2
+SCP2 sterol-binding domain [IPR003033]	0.3156583629893298	0.0014409720924675	0.9988502710127554	1.0	1.0	3	P51659,P22307	2