Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size Innate immune system 0.5659374929684615 3.805739035485835 0.0001413813939601 0.176915115266167 0.1946821794831117 270 P07602,Q93050,P15586,P11717,P07947,O00584,P05067,Q96JM3,P10253,P06280,Q08722,P04080,P14923,P09601,P61916,P20618,Q8WVQ1,Q99538,P16220,O15126,O00264,Q9UNP9,P17900,P04066,Q92820,P28072,O75874,O00754,P11279,P42785,Q9BTY2,P53634,P15924,Q13510,P10619,Q8IV08,P13473,P06756,P16278,Q9NQX7,P07686,P10321,Q92542,P27105,P04439,Q7Z434,O00560,Q969Q5,Q9UQB8,P01889,P49721 51 Glycosphingolipid metabolism 0.9558085102691536 3.1271066380824313 0.0017653588222426 0.9122310364764 0.5927358432075494 14 P06865,P07602,P16278,P17900,P07686,P06280,Q13510,P10619 8 Gpcr ligand binding 0.9642064782758828 2.776507492058545 0.0054946368689279 0.99949298904837 0.5927358432075494 9 P07602,P05067 2 Glycosaminoglycan metabolism 0.8881320393825382 2.7591928849580176 0.0057944322811114 0.999665254371983 0.5927358432075494 13 P54802,Q8NCH0,P06865,Q7LGA3,P15586,O43505,P16278,P07686,Q96L58 9 Regulation of insulin like growth factor igf transport and uptake by insulin like growth factor binding proteins igfbps 0.8616888917993086 2.668144246729929 0.0076271504440557 0.9999736183903072 0.5927358432075494 18 O43493,Q8NBJ4,P05067,Q06481,Q9BTY2,P19022 6 Plasma lipoprotein clearance 0.8398163391083997 2.628980440255686 0.0085641286656705 0.9999928155594088 0.5927358432075494 14 P61916,P01130,Q8WTV0,O15118 4 Peptide ligand binding receptors 0.9828728830621312 2.6002235607358104 0.0093163045750119 0.9999974735174112 0.5927358432075494 7 P07602,P05067 2 Class a 1 rhodopsin like receptors 0.9828728830621312 2.6002235607358104 0.0093163045750119 0.9999974735174112 0.5927358432075494 7 P07602,P05067 2 Plasma lipoprotein assembly remodeling and clearance 0.8183919867912212 2.4890101572806804 0.012809930594033 0.9999999805073344 0.5927358432075494 17 P61916,P01130,Q8WTV0,O15118 4 Binding and uptake of ligands by scavenger receptors 0.9025751462696864 2.473345280930745 0.0133854749156123 0.999999991267989 0.5927358432075494 8 Q5KU26,Q07954 2 Sphingolipid metabolism 0.8345483642051844 2.4646105800969895 0.0137162232638177 0.99999999449697 0.5927358432075494 24 P06865,P07602,P16278,P17900,P07686,P06280,Q13510,P10619,P04062 9 Ldl clearance 0.8330471633169335 2.448396548339443 0.0143493630419586 0.9999999977270992 0.5927358432075494 12 P61916,P01130,O15118 3 Cell surface interactions at the vascular wall 0.7922281724075093 2.3848290586166776 0.017087059030713 0.9999999999506568 0.5927358432075494 16 P06756,P35613,P05026,Q9Y624,Q08722,P05556,Q92896,P08195,P54709 9 Retrograde transport at the trans golgi network 0.8120234161834653 2.357166101773287 0.0184150077758222 0.9999999999923312 0.5927358432075494 12 O43493,P20645,P11717 3 Keratan sulfate keratin metabolism 0.9741320626276369 2.310077313049099 0.020883874213379 0.9999999999997607 0.5927358432075494 5 P15586,P16278,P06865,O43505 4 Diseases of carbohydrate metabolism 0.8291079893802509 2.237301115074289 0.0252666663958003 0.9999999999999996 0.5927358432075494 9 P54802,P15586,P10253 3 Lysosome vesicle biogenesis 0.7676946542756725 2.2297536704727157 0.0257638006549703 0.9999999999999998 0.5927358432075494 13 P15586,P05067 2 Keratan sulfate degradation 0.9738006124532148 2.229139343953497 0.0258046348327973 0.9999999999999998 0.5927358432075494 4 P15586,P16278,P06865 3 Integrin cell surface interactions 0.9506466984343108 2.224255632793558 0.0261312499355923 1.0 0.5927358432075494 5 Q9Y624,Q08722,P06756,P35613 4 Immunoregulatory interactions between a lymphoid and a non lymphoid cell 0.9506466984343104 2.2242556327935548 0.0261312499355925 1.0 0.5927358432075494 5 Q5KU26,P01889,P10321,P04439 4 Endosomal vacuolar pathway 0.9595100374276972 2.176958430550536 0.0294836691545281 1.0 0.5927358432075494 4 P10321,Q9UIQ6,P04439 3 Cell cell junction organization 0.8273908028123806 2.172925677314261 0.0297859115450389 1.0 0.5927358432075494 8 Q9Y624,P19022 2 Vitamin d calciferol metabolism 0.9555742804677152 2.1625395332423105 0.0305766132974238 1.0 0.5927358432075494 4 P98164,Q99538 2 Diseases of glycosylation 0.7408810806490168 2.1465078555808748 0.0318324827103311 1.0 0.5927358432075494 16 Q8NCH0,P06865,O43505,P16278,P07686,Q9UHI8,P10619 7 Visual phototransduction 0.8186243076582834 2.137172008263273 0.0325840038570763 1.0 0.5927358432075494 8 P01130,Q07954 2 Formation of the cornified envelope 0.9023871535465638 2.130457149562426 0.0331338898991711 1.0 0.5927358432075494 6 Q02487,Q14126,P14923,Q14574 4 Keratinization 0.9023871535465638 2.130457149562426 0.0331338898991711 1.0 0.5927358432075494 6 Q02487,Q14126,P14923,Q14574 4 Hyaluronan metabolism 0.9417646072818248 2.1117855616460184 0.0347048462558274 1.0 0.5927358432075494 4 P06865 1 Hyaluronan uptake and degradation 0.9417646072818248 2.1117855616460184 0.0347048462558274 1.0 0.5927358432075494 4 P06865 1 Eph ephrin mediated repulsion of cells 0.7479745382802937 2.0727925250212182 0.038191592401469 1.0 0.5977366458210767 12 P07947,Q92542,P09496,Q15375 4 Trans golgi network vesicle budding 0.7805307037857118 2.072590319797621 0.03821042269492 1.0 0.5977366458210767 35 O43493,P15586,P11717,P05067,O75976,Q99523,P02786 7 Amino acid transport across the plasma membrane 0.8866189989785467 2.07128074922143 0.0383325672243586 1.0 0.5977366458210767 6 P30825,Q9H2J7,Q15758,Q96QD8,P08195 5 Basigin interactions 0.8865283503871936 2.0709394597222786 0.0383644539952803 1.0 0.5977366458210767 6 P05026,P08195,P35613,P05556 4 Diseases associated with glycosaminoglycan metabolism 0.9278666212997584 2.0604569684673266 0.0393548755787998 1.0 0.5977366458210767 4 P07686,Q8NCH0,P06865 3 Chondroitin sulfate dermatan sulfate metabolism 0.9278666212997584 2.0604569684673266 0.0393548755787998 1.0 0.5977366458210767 4 P07686,Q8NCH0,P06865 3 Heparan sulfate heparin hs gag metabolism 0.9278666212997576 2.060456968467322 0.0393548755788002 1.0 0.5977366458210767 4 P54802,P16278,Q7LGA3 3 Interferon gamma signaling 0.7288289045602556 2.051268019274344 0.040240853090552 1.0 0.5977366458210767 13 P15260,P01889,P10321,P04439 4 Metabolism of fat soluble vitamins 0.8759672860946104 2.031092411699786 0.0422456210894921 1.0 0.6029329707772585 6 P01130,Q07954 2 O linked glycosylation 0.8753773078326148 2.02886146734949 0.0424724024440044 1.0 0.6029329707772585 6 Q10472,Q9UHI8,Q86SF2,O43505 4 Golgi associated vesicle biogenesis 0.7514511035615579 2.009992908269536 0.0444319394420111 1.0 0.6180078849661556 29 O43493,Q99523,P11717,O75976 4 Rnd1 gtpase cycle 0.7302151086042834 1.9922241735611772 0.0463464670460136 1.0 0.6292228297465985 12 P15924,P02786,O75976 3 Transferrin endocytosis and recycling 0.7496684978094897 1.9583771221519353 0.0501857772399723 1.0 0.6464801223323576 10 Q15904,P02786 2 Mucopolysaccharidoses 0.9755102040816318 1.9363237870549983 0.0528280572187704 1.0 0.6673783008279538 3 P54802,P15586 2 Cell junction organization 0.6896416131991313 1.9177829597910945 0.0551385373247024 1.0 0.6779086240724574 15 Q9Y624,P19022,P05556 3 Myogenesis 0.8023652232909732 1.9051238465488507 0.0567639742879633 1.0 0.6856490578467147 7 Q92859 1 O linked glycosylation of mucins 0.8832936372915903 1.89421581221972 0.0581963701387417 1.0 0.6905819157053201 4 Q10472,Q86SF2,O43505 3 Traf6 mediated nf kb activation 0.8827381064163632 1.8921289597910471 0.0584738006437663 1.0 0.6905819157053201 4 P05067 1 Extracellular matrix organization 0.7210544691092879 1.8906064784924983 0.0586768947984912 1.0 0.6905819157053201 27 Q92542,P06756,P35613,P05067,Q9UHI8,Q9Y624,Q08722 7 Antigen presentation folding assembly and peptide loading of class i mhc 0.6770206573092629 1.856597271865437 0.063368472374895 1.0 0.7394778513578857 15 Q9NZ08,P04439,P10321,P01889,P27824 5 Ecm proteoglycans 0.9500000000000024 1.843240008403982 0.0652939758568562 1.0 0.7463231025147106 3 P06756,P05067 2 Cargo recognition for clathrin mediated endocytosis 0.723398532372906 1.821349663179274 0.0685537216392031 1.0 0.7491942436284345 33 O43493,Q14108,P11717,P01130,P98164,P02786 6 G alpha i signalling events 0.686398625348039 1.793804549586749 0.0728443705352703 1.0 0.7898165214729709 22 P07602,P05067 2 Sensory perception 0.6882231563460692 1.78788918403482 0.0737938882533002 1.0 0.7927859618614507 23 P01130,Q07954 2 Transport of inorganic cations anions and amino acids oligopeptides 0.6831960514093819 1.775405033097306 0.0758310335669085 1.0 0.7927859618614507 12 P30825,Q9H2J7,Q15758,Q96QD8,P08195 5 Tgf beta receptor signaling in emt epithelial to mesenchymal transition 0.8452063064816948 1.7503616149917136 0.0800559351246188 1.0 0.7988190048304358 4 Q9Y624 1 Ion channel transport 0.6856882931459001 1.7461967877669404 0.0807767628150193 1.0 0.8002129668797239 25 Q15904,P27105,P05026,Q9C0H2,P51798,Q9NQ11,P51790,P54709 8 Apoptotic cleavage of cell adhesion proteins 0.8220259505692478 1.7406575703476292 0.081743619810866 1.0 0.8040068891397328 5 Q14126 1 Signaling by notch1 pest domain mutants in cancer 0.7582664612240809 1.7269222007092442 0.0841816367133208 1.0 0.8140544603564133 7 Q92542,Q92769 2 Stimuli sensing channels 0.7156178420406708 1.706007951231336 0.0880065991945238 1.0 0.8415631047976339 8 P27105,P51790,Q9C0H2 3 Signaling by notch2 0.9112470550996477 1.7008381017410548 0.0889733923956614 1.0 0.8449404229574198 3 Q92542 1 Pink1 prkn mediated mitophagy 0.7134578076013439 1.6967588860133678 0.0897422546411372 1.0 0.8464046893208632 8 Q8N4H5,P21796,Q13501 3 Adherens junctions interactions 0.7851537406204696 1.6818502377054576 0.09259788420486 1.0 0.8543949553588445 6 P19022 1 Mecp2 regulates transcription of neuronal ligands 0.8270535773373984 1.681288020260116 0.0927069836701943 1.0 0.8543949553588445 4 P16220 1 Rhob gtpase cycle 0.6499019373794915 1.675655186116463 0.0938057524966107 1.0 0.8543949553588445 18 P27105,O75955,P41440,P14923,P43121,P02786 6 Transport of bile salts and organic acids metal ions and amine compounds 0.824796915235757 1.6726804970639422 0.0943902106143586 1.0 0.8543949553588445 4 Q9H2J7 1 Advanced glycosylation endproduct receptor signaling 0.707592975632972 1.6716066898871984 0.0946019047246018 1.0 0.8543949553588445 8 P14314,P17931,P05067 3 Mitophagy 0.672358552753884 1.6680651520703549 0.095302793987098 1.0 0.8543949553588445 11 Q9NS69,Q8N4H5,P21796,Q13501 4 Regulation of mecp2 expression and activity 0.6810477660233301 1.6542418908191272 0.0980783744897966 1.0 0.8543949553588445 10 Q96ST3,Q14739,P16220 3 Sialic acid metabolism 0.816584536318752 1.6413203939342065 0.1007309248639898 1.0 0.8543949553588445 4 P10619 1 Signaling by notch1 0.7005051810057765 1.64113389187241 0.1007696247895584 1.0 0.8543949553588445 8 Q92542,Q92769 2 Syndecan interactions 0.7954390742001536 1.6381497459603267 0.1013904598757327 1.0 0.8543949553588445 5 Q9Y296,P06756,O14936,P05556 4 Non integrin membrane ecm interactions 0.7954390742001536 1.6381497459603267 0.1013904598757327 1.0 0.8543949553588445 5 Q9Y296,P06756,O14936,P05556 4 Amyloid fiber formation 0.772366252874628 1.6318073235771582 0.1027200820494691 1.0 0.8543949553588445 6 P05067 1 Regulation of ifng signaling 0.7935275618302061 1.6307523760332625 0.1029425800407111 1.0 0.8543949553588445 5 P15260 1 Slc mediated transmembrane transport 0.6538318200181267 1.6180946166553103 0.1056422085006836 1.0 0.8567175657313616 23 O00400,P08195,P35613,P11166,P30825,Q9H2J7,Q15758,Q96QD8,Q8TB61 9 Nucleotide binding domain leucine rich repeat containing receptor nlr signaling pathways 0.6900682262676037 1.596115634330314 0.1104629787129907 1.0 0.8593645293095379 8 P09601,P05067 2 Translation of sars cov 1 structural proteins 0.7803636619012642 1.579718674874582 0.1141713069498777 1.0 0.8782898864244787 5 Q10472,P27824 2 Striated muscle contraction 0.7786024507700949 1.5728793569944113 0.1157467558518607 1.0 0.885462682266735 5 P09493,P67936,P06753 3 Response to elevated platelet cytosolic ca2 0.6637680996348403 1.5389291976460626 0.1238215822094055 1.0 0.912970134193615 32 P07602,P05067,Q06481,Q08380,P13473 5 Netrin 1 signaling 0.6534567107867775 1.5294671082147584 0.126148687056455 1.0 0.912970134193615 10 Q92859 1 Cell cell communication 0.6366019542921659 1.5170208648737826 0.1292614162184562 1.0 0.912970134193615 24 Q9Y624,Q08722,P19022,P05556 4 Inflammasomes 0.7836580590326273 1.5150940204488954 0.1297485957457158 1.0 0.912970134193615 4 P05067 1 Purinergic signaling in leishmaniasis infection 0.7836580590326273 1.5150940204488954 0.1297485957457158 1.0 0.912970134193615 4 P05067 1 The nlrp3 inflammasome 0.7836580590326272 1.5150940204488943 0.129748595745716 1.0 0.912970134193615 4 P05067 1 Signal transduction by l1 0.6379425518790552 1.508679162903851 0.1313807929908335 1.0 0.912970134193615 11 P06756,P05556,O14786 3 Transcriptional regulation by e2f6 0.7405406420361933 1.506496498917229 0.1319397652175231 1.0 0.912970134193615 6 Q969R5,P45973 2 Chl1 interactions 0.8561560985037688 1.4969290926643597 0.1344117092867969 1.0 0.9207660503348608 3 O14786 1 Fatty acyl coa biosynthesis 0.5967155988333888 1.4751728659293604 0.1401660744432593 1.0 0.9342730665317214 14 Q9UMR5 1 Signaling by notch3 0.6957979920974556 1.469741950094295 0.1416316564759707 1.0 0.937628802727941 7 Q92542 1 Notch3 activation and transmission of signal to the nucleus 0.8417441002101702 1.4434398126012362 0.1488966157336215 1.0 0.9763363803104614 3 Q92542 1 Ion transport by p type atpases 0.6401845924743343 1.4223081015038967 0.1549368280366132 1.0 0.9952347331823116 9 P05026,Q9NQ11 2 Rhoc gtpase cycle 0.6263055062720987 1.4208444483724016 0.1553619856351 1.0 0.9952347331823116 27 Q07021,P27105,O75955,P41440,Q9H0H5,P14923,P43121,Q14739,P02786 9 Nuclear signaling by erbb4 0.8342327324458649 1.4155582822699346 0.1569048728982554 1.0 0.9952347331823116 3 Q92542 1 Insertion of tail anchored proteins into the endoplasmic reticulum membrane 0.6179725132699742 1.4152931656407333 0.1569825580001076 1.0 0.9952347331823116 11 P09601,P05067,P46379 3 Epha mediated growth cone collapse 0.6480578109807309 1.413323035550952 0.157560763858928 1.0 0.9952347331823116 8 Q15375 1 Cholesterol biosynthesis 0.5813265584982178 1.397445733079946 0.1622795746995842 1.0 1.0 14 Q15392,Q14739,Q16850,Q9UBM7 4 Foxo mediated transcription of oxidative stress metabolic and neuronal genes 0.7524592897659893 1.394977874153637 0.1630225118188382 1.0 1.0 4 Q96ST3 1 Mecp2 regulates neuronal receptors and channels 0.6430415189056468 1.3913487514133671 0.1641196971442102 1.0 1.0 8 Q96ST3,Q92769,P16220 3 Insulin receptor recycling 0.6270097951354995 1.3632545665553926 0.1728022954160768 1.0 1.0 9 Q15904 1 Signal amplification 0.6688672249824433 1.3575322775541478 0.1746121447067175 1.0 1.0 7 Q14344,Q16539,P63096 3 Rhoj gtpase cycle 0.586080022620678 1.355610828144283 0.175223024785081 1.0 1.0 18 P27105,P02786 2 Degradation of the extracellular matrix 0.7019043348223122 1.3532103777873097 0.1759884308175738 1.0 1.0 6 Q92542,P35613 2 Dap12 interactions 0.718941421333333 1.3400032439098275 0.1802442903033148 1.0 1.0 5 P10321 1 Synthesis secretion and inactivation of glucagon like peptide 1 glp 1 0.7123893805309859 1.3143400368008864 0.1887317996528681 1.0 1.0 5 P61009,P67812,Q99626,P35222 4 Incretin synthesis secretion and inactivation 0.7123893805309859 1.3143400368008864 0.1887317996528681 1.0 1.0 5 P61009,P67812,Q99626,P35222 4 Sars cov 1 infection 0.5676653610810113 1.3113536352230233 0.1897383154748655 1.0 1.0 15 P14314,Q10472,Q96FZ7,Q9UQN3,P27824 5 Iron uptake and transport 0.5735624748469312 1.3083022854037658 0.1907708002897257 1.0 1.0 17 Q15904,Q93050,P02786 3 Pka mediated phosphorylation of creb 0.7251654521781892 1.2897560531290106 0.1971353708770624 1.0 1.0 4 P16220 1 Creb1 phosphorylation through the activation of adenylate cyclase 0.7251654521781892 1.2897560531290106 0.1971353708770624 1.0 1.0 4 P16220 1 Rnd3 gtpase cycle 0.5629550753815015 1.2873812654633014 0.1979614309647344 1.0 1.0 15 P15924,O75976 2 Adora2b mediated anti inflammatory cytokines production 0.6075748935292964 1.2758259399021012 0.2020170557075888 1.0 1.0 9 P63096,P10644,P16220 3 Signalling to ras 0.7956240385461382 1.272425628652325 0.2032219329184899 1.0 1.0 3 P11233 1 Collagen biosynthesis and modifying enzymes 0.587038533039755 1.2696154994358713 0.2042216256452615 1.0 1.0 11 O75718,Q32P28,O15460,O00469,O60568,P50454,Q02809 7 Nef mediated downregulation of mhc class i complex cell surface expression 0.7184499682132958 1.2638807519316828 0.2062728313961095 1.0 1.0 4 P04439 1 Hs gag degradation 0.975178510710643 1.2603997651819931 0.2075251863387013 1.0 1.0 2 P54802 1 Rhoq gtpase cycle 0.5734905917285198 1.259603133464632 0.2078125645974187 1.0 1.0 20 P27105,P02786 2 Cs ds degradation 0.9731383883032994 1.25303694483906 0.2101922617010754 1.0 1.0 2 P06865 1 Alpha linolenic omega3 and linoleic omega6 acid metabolism 0.6953710006807423 1.2476728076134067 0.2121509033806301 1.0 1.0 5 Q15067,O95864,P33121,P51659 4 Transcriptional regulation by mecp2 0.5515584607399799 1.2460806875686772 0.2127347741439438 1.0 1.0 14 Q96ST3,Q14739,Q92769,P16220 4 Nef mediates down modulation of cell surface receptors by recruiting them to clathrin adapters 0.5879680766600864 1.2290286148943146 0.219061077581776 1.0 1.0 10 O94973,Q10567,P04439,Q96CW1 4 Nrif signals cell death from the nucleus 0.9642978578714724 1.2211817659755386 0.2220172064811683 1.0 1.0 2 Q92542 1 Apoptotic factor mediated response 0.6863814560673839 1.212472310986653 0.2253316354817984 1.0 1.0 5 Q9NR28 1 Cdc42 gtpase cycle 0.5833490543023393 1.202619130676131 0.2291237411269213 1.0 1.0 27 P27105,Q9H0H5,P14923,Q9UQB8,Q14739,P02786 6 Maturation of sars cov 1 spike protein 0.6992088413054586 1.1898455990141386 0.2341070835389798 1.0 1.0 4 P27824 1 Egr2 and sox10 mediated initiation of schwann cell myelination 0.6985859757569715 1.187452496624705 0.2350491834583701 1.0 1.0 4 Q16850 1 Synaptic adhesion like molecules 0.6600606255543333 1.1864661199309217 0.2354382735007305 1.0 1.0 6 O75955,P41440 2 Synthesis of bile acids and bile salts 0.6951343994555909 1.1741963138245686 0.2403164021814383 1.0 1.0 4 Q96SU4,P22059,P51659 3 Bile acid and bile salt metabolism 0.6951343994555909 1.1741963138245686 0.2403164021814383 1.0 1.0 4 Q96SU4,P22059,P51659 3 Diseases associated with o glycosylation of proteins 0.951037062223735 1.1735712072832938 0.2405668196033454 1.0 1.0 2 O43505 1 Molecules associated with elastic fibres 0.949676980618839 1.1687010417192196 0.2425241021134221 1.0 1.0 2 P06756 1 Laminin interactions 0.949676980618839 1.1687010417192196 0.2425241021134221 1.0 1.0 2 P06756 1 Elastic fibre formation 0.949676980618839 1.1687010417192196 0.2425241021134221 1.0 1.0 2 P06756 1 Notch hlh transcription pathway 0.6912153193037562 1.159155816917918 0.2463926774467717 1.0 1.0 4 Q92769,Q06330 2 Interferon alpha beta signaling 0.5695538149016436 1.1438987414410506 0.2526656330591881 1.0 1.0 10 P10321,P04439 2 Ripk1 mediated regulated necrosis 0.5599882443354801 1.1415781492519008 0.2536294109118702 1.0 1.0 11 Q14254,Q8WUM4,O75955,P41440,O00560 5 Apobec3g mediated resistance to hiv 1 infection 0.7593407447732012 1.1387321297256974 0.2548148974109818 1.0 1.0 3 P17096 1 Cytochrome p450 arranged by substrate type 0.7588435374149843 1.13690947228533 0.2555761319034868 1.0 1.0 3 P16435,Q16850 2 Diseases of metabolism 0.5959008326653401 1.100337736122199 0.2711849961276145 1.0 1.0 39 P54802,Q8NCH0,P06865,O43505,P15586,P16278,P07686,Q9UHI8,P10253,O75874,P10619 11 Crmps in sema3a signaling 0.6571747385270145 1.0983648721340094 0.2720451949947187 1.0 1.0 5 O14786 1 Rhoa gtpase cycle 0.5974462508311766 1.095350694025717 0.2733630262779591 1.0 1.0 40 Q15904,Q8NBN3,P27105,O75955,P41440,Q9H0H5,P14923,P43121,Q14739,P02786 10 Diseases associated with glycosylation precursor biosynthesis 0.6045901083746968 1.0883001594671713 0.2764626201745663 1.0 1.0 7 P10619 1 Noncanonical activation of notch3 0.9268956137368268 1.0875452199743385 0.2767959253011234 1.0 1.0 2 Q92542 1 Neutrophil degranulation 0.6658384078108198 1.0805142964257706 0.279913223982063 1.0 1.0 169 P07602,Q93050,P15586,P11717,O00584,Q96JM3,P10253,P06280,Q08722,P04080,P14923,P20618,P61916,Q8WVQ1,O15126,O00264,Q9UNP9,P17900,P04066,Q92820,O75874,O00754,P11279,P42785,Q9BTY2,P53634,P15924,Q13510,P10619,P13473,P06756,P16278,Q9NQX7,P07686,P10321,Q92542,P27105,P04439,O00560,P01889,Q969Q5 41 Tysnd1 cleaves peroxisomal proteins 0.6522876905814068 1.0793349155680405 0.28043845329963 1.0 1.0 5 Q2T9J0,P51659 2 Formation of fibrin clot clotting cascade 0.9115946956817456 1.0335554494868184 0.3013440355741368 1.0 1.0 2 P42785 1 Intrinsic pathway of fibrin clot formation 0.9115946956817456 1.0335554494868184 0.3013440355741368 1.0 1.0 2 P42785 1 Ddx58 ifih1 mediated induction of interferon alpha beta 0.5248589356210073 1.01634883618812 0.309463300527077 1.0 1.0 12 P05067 1 Sema4d mediated inhibition of cell attachment and migration 0.7255076545592096 1.0155582962443988 0.3098397726526751 1.0 1.0 3 Q9NWH9 1 Thromboxane signalling through tp receptor 0.7252713048023575 1.0147049528110053 0.3102464925052248 1.0 1.0 3 Q14344 1 Rac3 gtpase cycle 0.5543825605730169 0.996555784686229 0.3189801768135263 1.0 1.0 31 Q14126,Q9H0H5,P05556,P43121,Q9UQB8,Q15758,Q14739,P02786 8 P75 ntr receptor mediated signalling 0.5009788074398746 0.9874320124770806 0.323430897266483 1.0 1.0 14 Q92542,Q13501,Q92769 3 Cell death signalling via nrage nrif and nade 0.5431061783295857 0.9848435248670938 0.3247009374760623 1.0 1.0 9 Q92542,Q13501 2 Sumoylation of transcription factors 0.643611602627587 0.977924236247788 0.3281117971964309 1.0 1.0 4 O75925 1 Regulated necrosis 0.5111388096698003 0.9733567438213234 0.3303760295251248 1.0 1.0 18 Q96FZ7,Q14254,Q9UQN3,Q9Y3E7,Q8WUM4,O75955,P41440,O00560 8 Signaling by erbb4 0.6062557630757528 0.9728377245624282 0.3306339601165744 1.0 1.0 6 Q92542,Q96J02,P61201 3 Protein protein interactions at synapses 0.5151837955385066 0.9694421106742296 0.3323246502628638 1.0 1.0 12 P11171,O75955,P41440 3 Synthesis secretion and inactivation of glucose dependent insulinotropic polypeptide gip 0.7119047619047574 0.9666415738699964 0.3337232439704687 1.0 1.0 3 P61009,P67812 2 Synthesis secretion and deacylation of ghrelin 0.7119047619047574 0.9666415738699964 0.3337232439704687 1.0 1.0 3 P61009,P67812 2 P38mapk events 0.8901734104046289 0.9588323015751652 0.3376432337216792 1.0 1.0 2 P11233 1 Synthesis of substrates in n glycan biosythesis 0.497224535308535 0.9515571752934112 0.3413216089153379 1.0 1.0 15 P10619 1 The role of nef in hiv 1 replication and disease pathogenesis 0.5110110296937546 0.9492412372269804 0.3424979326755015 1.0 1.0 12 Q10567,O94973,P04439 3 Notch1 intracellular domain regulates transcription 0.5984528158752489 0.9421159744973712 0.346133266746629 1.0 1.0 6 Q92769 1 Antigen processing cross presentation 0.5879251218785242 0.9359867358946916 0.3492800170555945 1.0 1.0 49 P06756,Q9UIQ6,P04439,P10321,Q9UBG0,P01889,P49721 7 Cargo concentration in the er 0.4903933435829752 0.9334042667126732 0.3506112782517763 1.0 1.0 14 Q13190,O95486,P49755,P53634,P49257,Q12907 6 Antimicrobial peptides 0.8823529411764721 0.931842184231248 0.3514180902906989 1.0 1.0 2 Q96JM3 1 Cardiac conduction 0.5228711645426989 0.9283694573562572 0.3532159560801564 1.0 1.0 10 P05026,P54709,Q12797,P20020 4 Ion homeostasis 0.5228711645426989 0.9283694573562572 0.3532159560801564 1.0 1.0 10 P05026,P54709,Q12797,P20020 4 Collagen formation 0.4973910423697802 0.924411068754612 0.3552723339482964 1.0 1.0 13 O75718,Q32P28,O15460,Q15149,O00469,O60568,P50454,Q02809 8 Resolution of d loop structures 0.5652077525989441 0.9241190876677472 0.3554243163458537 1.0 1.0 7 Q9UQ84 1 Resolution of d loop structures through synthesis dependent strand annealing sdsa 0.5652077525989441 0.9241190876677472 0.3554243163458537 1.0 1.0 7 Q9UQ84 1 Signaling by vegf 0.5192028174106089 0.905124143630202 0.3653996227579821 1.0 1.0 25 P06756,O14786,P04792,P14923,Q9UQB8 5 Transport of vitamins nucleosides and related molecules 0.5565970945246442 0.888512154113762 0.3742653209572779 1.0 1.0 7 O00400 1 Pecam1 interactions 0.6027587593337725 0.8884327990524764 0.374307988956466 1.0 1.0 5 P06756 1 Miro gtpase cycle 0.6894557823129223 0.886924062063583 0.3751197859312263 1.0 1.0 3 Q8IXI1,Q8IWA4 2 G alpha s signalling events 0.5973259900076461 0.867798725046036 0.3855045281257618 1.0 1.0 5 P04899,P63096,Q9Y3E5 3 Metabolism of steroid hormones 0.5787311826150515 0.8649739725747794 0.3870530744750393 1.0 1.0 6 O95772,Q14849,P22570 3 Regulation of insulin secretion 0.4905313214987225 0.8504887509902742 0.3950534119153204 1.0 1.0 12 P29966,P10644,P11166 3 Diseases of dna repair 0.5053969818739305 0.8483360649823959 0.3962508379028315 1.0 1.0 10 Q9UQ84 1 Met activates ptk2 signaling 0.8565113906834475 0.8439608560126152 0.3986912797196962 1.0 1.0 2 P05556 1 Met interacts with tns proteins 0.8565113906834475 0.8439608560126152 0.3986912797196962 1.0 1.0 2 P05556 1 Vldlr internalisation and degradation 0.5446160683850125 0.839229157560338 0.4013407282494563 1.0 1.0 7 P09496,O94973,Q96CW1 3 Wnt5a dependent internalization of fzd2 fzd5 and ror2 0.5446160683850125 0.839229157560338 0.4013407282494563 1.0 1.0 7 P09496,O94973,Q96CW1 3 Wnt5a dependent internalization of fzd4 0.5446160683850125 0.839229157560338 0.4013407282494563 1.0 1.0 7 P09496,O94973,Q96CW1 3 Rab geranylgeranylation 0.4779084850526513 0.8369442379519372 0.4026239126065922 1.0 1.0 16 P61020,P20339,Q92930,Q9H0U4,P51149,P61106,Q9NP72,Q969Q5 8 Pi3k akt signaling in cancer 0.5152758847786414 0.8295793566550813 0.4067766522757579 1.0 1.0 8 P16220,Q9NWH9 2 Budding and maturation of hiv virion 0.4781598173488831 0.8293786701309985 0.4068901672816822 1.0 1.0 13 Q9NZ09,Q96FZ7,Q9UQN3,Q9Y3E7,Q8WUM4,Q9UN37 6 Rhoh gtpase cycle 0.4898097545482766 0.8174737839204678 0.4136577251414803 1.0 1.0 21 P27105,P02786 2 Runx1 regulates genes involved in megakaryocyte differentiation and platelet function 0.4982040876099308 0.8155856191065758 0.4147371772230579 1.0 1.0 10 Q96ST3,Q15291 2 Intra golgi traffic 0.5106891562896543 0.8097202019289249 0.4181010044913755 1.0 1.0 8 Q9NRW7,O00461,Q13190 3 Clathrin mediated endocytosis 0.5713145449213209 0.80456971049197 0.4210680269380962 1.0 1.0 53 O43493,Q14108,P11717,P01130,P98164,P02786 6 Citric acid cycle tca cycle 0.4778362535279917 0.8043377709116473 0.4212019295346443 1.0 1.0 18 Q13423,P48735 2 Sensory processing of sound 0.4681053194313948 0.8037802432324221 0.4215239017809673 1.0 1.0 15 Q12792,P35579,O14936,P20020 4 Toll like receptor tlr1 tlr2 cascade 0.4709823182576997 0.8019775922005191 0.4225659202813758 1.0 1.0 16 Q16539,P05067,P16220 3 Biosynthesis of the n glycan precursor dolichol lipid linked oligosaccharide llo and transfer to a nascent protein 0.4712470765899006 0.7871692763908972 0.4311827799416279 1.0 1.0 17 P10619 1 Pregnenolone biosynthesis 0.5920453772303209 0.7870970441659704 0.4312250595803559 1.0 1.0 4 O95772,Q14849 2 Rhof gtpase cycle 0.4673517852069972 0.7837044197496768 0.4332135685466047 1.0 1.0 16 P43121 1 Rhog gtpase cycle 0.5161975235562665 0.774326112267364 0.4387379656619039 1.0 1.0 33 P43121,Q14126,P02786,P05556 4 Gaba b receptor activation 0.5862538278325932 0.7662168416258067 0.4435472889698508 1.0 1.0 4 P04899,P63096,P08754 3 Gaba receptor activation 0.5862538278325932 0.7662168416258067 0.4435472889698508 1.0 1.0 4 P04899,P63096,P08754 3 Adp signalling through p2y purinoceptor 12 0.5862538278325932 0.7662168416258067 0.4435472889698508 1.0 1.0 4 P04899,P63096,P08754 3 G alpha z signalling events 0.5862538278325932 0.7662168416258067 0.4435472889698508 1.0 1.0 4 P04899,P63096,P08754 3 Sensory processing of sound by outer hair cells of the cochlea 0.4796136235844184 0.7633365505443446 0.4452627093417931 1.0 1.0 11 Q12792,P35579,O14936 3 Translation of sars cov 2 structural proteins 0.4599481775177614 0.7627664742893727 0.445602678522639 1.0 1.0 15 P14314,P27824,P39656,Q10472 4 Signaling by insulin receptor 0.4595136745674983 0.7605881123088453 0.4469031223658732 1.0 1.0 15 Q15904 1 Anti inflammatory response favouring leishmania parasite infection 0.4591694517973006 0.7588628485326175 0.4479346049245269 1.0 1.0 15 Q16539,P63096,P07947,Q9Y3E5,P10644,P16220 6 Stat3 nuclear events downstream of alk signaling 0.5835481116473279 0.7565093396637607 0.4493438748552749 1.0 1.0 4 Q96ST3 1 Nef mediated cd8 down regulation 0.5469897870236294 0.7429215644299446 0.4575291690847658 1.0 1.0 6 Q9UI12,P63010,O94973,Q96CW1 4 Nef mediated cd4 down regulation 0.5469897870236294 0.7429215644299446 0.4575291690847658 1.0 1.0 6 Q9UI12,P63010,O94973,Q96CW1 4 Ca dependent events 0.5196707309509033 0.7378909274657366 0.4605807325644457 1.0 1.0 7 P16220 1 Extra nuclear estrogen signaling 0.4730820318991157 0.7332012334232906 0.4634357031855098 1.0 1.0 11 P16220 1 Rac2 gtpase cycle 0.5072452488864375 0.729324124708153 0.4658034185343864 1.0 1.0 33 Q14126,P05556,P43121,Q14739,P02786 5 Adenylate cyclase inhibitory pathway 0.6421768707482994 0.7245946166158127 0.4687007625025934 1.0 1.0 3 P04899,P63096 2 Transcriptional activation of mitochondrial biogenesis 0.4558892471817419 0.720580402391287 0.4711677150202207 1.0 1.0 13 P48735 1 G alpha q signalling events 0.469709936378374 0.7177068462336176 0.4729380610899816 1.0 1.0 11 P05067 1 Peptide hormone metabolism 0.447296939302797 0.6996423310675572 0.4841506994677236 1.0 1.0 15 Q99626,Q96KP1,O00471,P67812,O75787 5 Fcgr3a mediated il10 synthesis 0.4846332678897612 0.6981646837995509 0.4850742097767355 1.0 1.0 8 P07947,P16220 2 Rac1 gtpase cycle 0.5132328830313526 0.6921153336480954 0.4888649029466485 1.0 1.0 38 Q14344,Q9H0H5,P05556,P43121,Q9UQB8,Q15758,Q14739,P02786 8 Ire1alpha activates chaperones 0.4686824599849826 0.6812498950796123 0.4957133815061314 1.0 1.0 23 O14773,P43307 2 Vesicle mediated transport 0.478579191778417 0.6712937796520637 0.5020333965295993 1.0 1.0 233 Q10472,O43493,P35606,Q96FZ7,Q9UHD9,Q9NZ09,Q9UIQ6,P60520,P15586,P11717,Q12981,P05067,P09496,O94973,Q07954,O75976,P01130,Q99523,Q92747,P02786,Q14108,Q13561,Q9H0U4,Q5KU26,Q9Y3P9,P53634,P98164,Q12907,Q9UQN3,Q96KP1,O95486,O00139,Q8WTV0,Q9H0H5,O00461,Q10471,Q9NQT8,Q9Y296,Q9BVA1,P20645,O60499,Q9UNF0,O00471,Q14807,P11233,P84085,P24390 47 Nod1 2 signaling pathway 0.5572981259299122 0.664094960214992 0.506629535562575 1.0 1.0 4 Q16539,Q96J02 2 Adrenaline noradrenaline inhibits insulin secretion 0.6210159970890818 0.6551781012657207 0.5123530918939576 1.0 1.0 3 P63096 1 Metabolic disorders of biological oxidation enzymes 0.5313972593900786 0.6257555088768793 0.5314753181466876 1.0 1.0 5 P48637,P22570 2 Toll like receptor cascades 0.4645669282428455 0.6168521299644139 0.5373322638647031 1.0 1.0 26 P05067,Q99538 2 Platelet activation signaling and aggregation 0.5338952400915113 0.6138564697294855 0.5393101775815727 1.0 1.0 53 P07602,P05067,Q06481,Q08380,P13473 5 Cd163 mediating an anti inflammatory response 0.7813668820129276 0.6038114987559646 0.545968973665159 1.0 1.0 2 Q16539 1 Suppression of phagosomal maturation 0.4851987047328784 0.6018939954551015 0.5472447014254875 1.0 1.0 7 O14964,Q9UI12,P20339,P51149,P52294 5 Maturation of sars cov 2 spike protein 0.4439978348222147 0.6013122693109044 0.5476320191184396 1.0 1.0 11 P14314,P04843,P39656,P27824,Q16706 5 Nephrin family interactions 0.4850136239781851 0.6011800913654123 0.5477200430959319 1.0 1.0 7 O14936,Q01082,O43707,Q13813,Q9Y5K6,P12814 6 Toll like receptor 9 tlr9 cascade 0.4391290776266798 0.5968799183800892 0.5505875556011204 1.0 1.0 19 Q16539,P05067,P16220 3 Translation of replicase and assembly of the replication transcription complex 0.4834457805469419 0.5951405222505874 0.5517495437688407 1.0 1.0 7 Q96FZ7,Q9UQN3 2 Met activates pi3k akt signaling 0.7779666780006843 0.5936381663109191 0.5527541480789007 1.0 1.0 2 Q9NWH9 1 Homologous dna pairing and strand exchange 0.4223254730369307 0.5931190294862609 0.5531014960373453 1.0 1.0 14 Q9UQ84 1 Hdr through single strand annealing ssa 0.4223254730369307 0.5931190294862609 0.5531014960373453 1.0 1.0 14 Q9UQ84 1 Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane 0.5355563116706368 0.590400174837113 0.5549223934083858 1.0 1.0 4 P12235,P12236,P36404 3 Sumoylation of chromatin organization proteins 0.4808455948571063 0.5850137105694169 0.5585384978322709 1.0 1.0 34 O75925,Q96EE3,Q969R5,P78406,P45973,Q8NFH3,Q92769 7 Sealing of the nuclear envelope ne by escrt iii 0.4255401468935601 0.5758786617721012 0.5646971994924652 1.0 1.0 13 Q96FZ7,Q9UQN3,Q9Y3E7,Q9BVA1,Q9UN37 5 Glycerophospholipid biosynthesis 0.4529667247394576 0.5748999503554576 0.565358963507326 1.0 1.0 25 P67870,O15228,Q8NCC3,P48651,O14735,Q6P1A2,Q8IV08 7 Regulation of kit signaling 0.5932965742234061 0.5681726430967154 0.5699177454127655 1.0 1.0 3 P07947 1 Metabolism of steroids 0.4917772221934763 0.5602466116882756 0.5753112375590332 1.0 1.0 40 Q15392,O95772,Q9UBM7,Q99538,P04062,P98164,Q14739,Q16850 8 Atf6 atf6 alpha activates chaperones 0.7596055763345833 0.5399675986427303 0.5892193777693921 1.0 1.0 2 P27797 1 Atf6 atf6 alpha activates chaperone genes 0.7596055763345833 0.5399675986427303 0.5892193777693921 1.0 1.0 2 P27797 1 Translocation of slc2a4 glut4 to the plasma membrane 0.4630969488722459 0.5395918445349431 0.5894785421488427 1.0 1.0 31 P11233,Q96KP1,Q9UIQ6 3 Potential therapeutics for sars 0.4795043892825367 0.5390033167572198 0.5898845659670235 1.0 1.0 37 P15260,Q99720,P05026,P05556,P62942,P54709 6 Endosomal sorting complex required for transport escrt 0.4101206732262455 0.5345707297214031 0.5929467282811896 1.0 1.0 14 O14964,Q9NZ09,Q96FZ7,Q9UQN3,Q9Y3E7,Q9UN37 6 Signaling by gpcr 0.4834658941472666 0.5325318431364928 0.5943576933313004 1.0 1.0 39 P07602,P05067 2 Dissolution of fibrin clot 0.7562053723223477 0.5302743683489012 0.5959217153219467 1.0 1.0 2 P07355 1 Transcriptional regulation of granulopoiesis 0.4658475356267699 0.5284056476483104 0.5972178184903449 1.0 1.0 7 P35659,P16220 2 Circadian clock 0.4270491655478033 0.5267297519077824 0.5983812717337318 1.0 1.0 11 P43490,P16220 2 G protein mediated events 0.4255186428783211 0.5200969541548851 0.602996001203344 1.0 1.0 11 P10644,P16220 2 Polo like kinase mediated events 0.5769591455132517 0.5193317584972743 0.6035294103109186 1.0 1.0 3 P53350 1 Synthesis of pips at the er membrane 0.7521251275076587 0.5187487228984968 0.6039359800593513 1.0 1.0 2 Q13614 1 Apoptotic cleavage of cellular proteins 0.4090896443379681 0.5142619314152574 0.6070688735343703 1.0 1.0 15 Q14126 1 Trafficking of glur2 containing ampa receptors 0.4828055839291678 0.5094094111864281 0.6104652810190523 1.0 1.0 6 Q96CW1,P63010,O94973,O95782,P53680 5 Tristetraprolin ttp zfp36 binds and destabilizes mrna 0.4216750565960468 0.5035221759268611 0.6145971930669294 1.0 1.0 11 Q92973,Q9Y3B2 2 Linoleic acid la metabolism 0.7463447806868453 0.5026237490723301 0.6152288287100958 1.0 1.0 2 O95864 1 Signaling by tgf beta receptor complex 0.4192552676299637 0.5018963828293407 0.6157404098313557 1.0 1.0 19 Q9Y624 1 Inla mediated entry of listeria monocytogenes into host cells 0.7460047602856218 0.5016827640309807 0.6158906906049604 1.0 1.0 2 O60716 1 Kinesins 0.4041158279719198 0.4758299163576108 0.6341955548020175 1.0 1.0 16 Q9NQT8,O00139,Q9BVA1,Q9H0H5 4 Ksrp khsrp binds and destabilizes mrna 0.4022529143806225 0.4690659294267055 0.6390225113052674 1.0 1.0 13 Q15024,Q9Y3B2 2 Aquaporin mediated transport 0.4837842428302622 0.4657463812754138 0.6413970488633685 1.0 1.0 5 P10644 1 Sars cov 2 infection 0.4296972481935571 0.4644306619680794 0.6423392263968073 1.0 1.0 25 Q10472,P14314,Q96FZ7,Q9UQN3,Q9Y3E7,P39656,P27824 7 Met promotes cell motility 0.4692326220044294 0.4633625539725449 0.6431045147632739 1.0 1.0 6 P05556,Q9NWH9 2 Cytosolic sulfonation of small molecules 0.4781098184033944 0.4478406272231282 0.6542682203201817 1.0 1.0 5 Q9NX62 1 Hdms demethylate histones 0.4388196130992804 0.4303558675530277 0.6669367932637977 1.0 1.0 7 Q9Y2K7,Q8NB78 2 Regulation of bach1 activity 0.5403868380877725 0.417774080261084 0.6761123034804293 1.0 1.0 3 Q13616 1 Metabolism of folate and pterines 0.4138994293120966 0.4135987361204001 0.6791679990080057 1.0 1.0 8 Q9H2D1,P41440 2 Sumoylation of transcription cofactors 0.398755908645784 0.407424664949264 0.6836961145244151 1.0 1.0 11 O75925 1 Pyroptosis 0.4282577945943455 0.393781622677825 0.6937422734504213 1.0 1.0 7 Q96FZ7,Q9UQN3 2 Tgf beta receptor signaling activates smads 0.4062360852793241 0.3851852276674177 0.7001001871994776 1.0 1.0 8 Q9UNE7,P62942 2 Death receptor signalling 0.3899475295693173 0.3823337677251887 0.7022138107687714 1.0 1.0 18 Q92542,Q13501,Q92769 3 Prevention of phagosomal lysosomal fusion 0.4671670431871966 0.3818582271319682 0.7025665264199454 1.0 1.0 4 O14964,P51149 2 Synthesis of bile acids and bile salts via 7alpha hydroxycholesterol 0.6946616797007884 0.3701209601788716 0.7112923653932324 1.0 1.0 2 P51659 1 Beta oxidation of pristanoyl coa 0.6946616797007884 0.3701209601788716 0.7112923653932324 1.0 1.0 2 P51659 1 Semaphorin interactions 0.3920346030670816 0.3635602135281407 0.7161864414334622 1.0 1.0 20 P05556,O14786 2 Signaling by tgfb family members 0.3910042718326508 0.3590437163837669 0.7195623857367655 1.0 1.0 20 Q9Y624 1 Myd88 independent tlr4 cascade 0.3825979932075619 0.35009732103223 0.7262656613369862 1.0 1.0 18 Q16539,P05067,P16220 3 Muscle contraction 0.4043082802620619 0.3495802666363407 0.7266537225645617 1.0 1.0 25 P08670,P07355,P05026,P09493,Q12797,P20020,P06753,P67936,P54709 9 Sulfide oxidation to sulfate 0.6851411084665124 0.3482237043527545 0.7276721870119616 1.0 1.0 2 Q16762 1 Chylomicron assembly 0.67902074124448 0.3345924898993886 0.7379325108924646 1.0 1.0 2 Q9Y6B6 1 Signalling to erks 0.389846972692592 0.3265689383422324 0.7439939401008298 1.0 1.0 8 P11233 1 Mhc class ii antigen presentation 0.4644244866489157 0.3244676433969953 0.7455840151236801 1.0 1.0 49 Q13561,O95486,Q9BVA1,P09496,O00139,Q9H0H5,P53634,P10619,P27824,Q99538,Q14807 11 Pyruvate metabolism 0.3633204776540267 0.3232362339227825 0.7465163417940996 1.0 1.0 14 P35613 1 Eph ephrin signaling 0.4099946892879216 0.3222378289131441 0.7472725282871542 1.0 1.0 29 Q92542,P07947,P09496,O00560,O94973,Q15375 6 Plasma lipoprotein assembly 0.4948979591836621 0.3092203492550064 0.75715391547116 1.0 1.0 3 P07237,Q9Y6B6 2 Listeria monocytogenes entry into host cells 0.3843723752939401 0.3076992342417467 0.7583112024631513 1.0 1.0 8 O14964,P42566,O60716,Q9NWH9,P62993 5 Glutathione conjugation 0.3628962336880695 0.3075904414527733 0.758393994429192 1.0 1.0 15 O15217 1 Beta oxidation of very long chain fatty acids 0.4360829041427624 0.3022840578370555 0.762435530243063 1.0 1.0 4 P51659,Q08426 2 Ptk6 regulates rho gtpases ras gtpase and map kinases 0.6592995579734867 0.2931177060973435 0.7694321833623354 1.0 1.0 2 P61586 1 Interaction between l1 and ankyrins 0.484693877551011 0.2879198387830993 0.7734081004987736 1.0 1.0 3 Q12955,Q13813 2 Tetrahydrobiopterin bh4 synthesis recycling salvage and regulation 0.4829931972789097 0.2844844970843351 0.7760391129953386 1.0 1.0 3 P07900,P00374 2 Scavenging by class f receptors 0.4276964954066058 0.2827605388695485 0.7773604057298962 1.0 1.0 4 P27797,P07900,Q9Y4L1 3 Assembly of the orc complex at the origin of replication 0.4080944338752594 0.2772584527523437 0.781581659308054 1.0 1.0 6 Q9Y619 1 Hemostasis 0.5569592772843274 0.2761371940369463 0.7824426941259541 1.0 1.0 113 P07602,P35613,Q07021,P07947,P05067,Q06481,Q08722,P05556,P45973,Q96ST3,Q92769,Q14344,P05026,P42785,Q92896,P13473,P06756,Q16539,P07355,Q9BWS9,Q9Y624,O00139,Q08380,Q9H0H5,P10644,P54709,Q9NQT8,Q9BVA1,O43852,Q14807,P08195 31 Glutathione synthesis and recycling 0.4060281927906017 0.2716922094046088 0.7858586920412038 1.0 1.0 6 O75223 1 Degradation of cysteine and homocysteine 0.413206262763791 0.2662681390092469 0.7900327090024026 1.0 1.0 5 Q99757,Q16762,P00505,Q9UBX3 4 Synthesis of pips at the early endosome membrane 0.4118729780038012 0.2630490973718181 0.7925127369786926 1.0 1.0 5 Q13614 1 Formation of the beta catenin tcf transactivating complex 0.3666218401789209 0.2583169374483748 0.7961623155522579 1.0 1.0 9 Q15291 1 Runx1 regulates expression of components of tight junctions 0.6409384563073832 0.2579681471168265 0.7964314903108942 1.0 1.0 2 Q16625 1 Pyruvate metabolism and citric acid tca cycle 0.400647308963142 0.2456408140739555 0.8059602919573587 1.0 1.0 32 Q13423,P48735,P21796,P35613 4 Slc transporter disorders 0.4025333363145762 0.2414618110767648 0.8091972112523318 1.0 1.0 33 O00400,P35613,P11166,Q96EE3,P78406,Q8NFH3,P08195 7 Interleukin 1 signaling 0.4235681455472121 0.2359520416387471 0.8134698847116151 1.0 1.0 41 P28070,Q13616,Q13501,P05067,P28072,P20618,P49721 7 Dag and ip3 signaling 0.3603724038535536 0.2297049903263677 0.8183210168723416 1.0 1.0 8 P16220 1 Processing of dna double strand break ends 0.3655477674303247 0.2267964925036003 0.8205819912220387 1.0 1.0 22 Q12888,Q14191,Q9UQ84 3 Vxpx cargo targeting to cilium 0.3559686251538568 0.2237136359492647 0.8229801348970842 1.0 1.0 9 Q96KP1,O00471 2 Rhod gtpase cycle 0.3773331271476461 0.2119793427165872 0.8321231502295245 1.0 1.0 27 P12814,Q16643,Q9H0H5,P43121,P49257,Q14739,P50402,Q5JTV8 8 Heme signaling 0.3761492607628593 0.1974239030321856 0.8434958257915892 1.0 1.0 6 P16220 1 Intrinsic pathway for apoptosis 0.3375210418913655 0.1941549609058158 0.8460545477328969 1.0 1.0 16 Q07021,Q9NR28 2 Glutamate and glutamine metabolism 0.3596730245231632 0.1878392901908759 0.8510026348207143 1.0 1.0 7 P32322,P04181,P00505,O94925,P54886,P00367 6 Butyrate response factor 1 brf1 binds and destabilizes mrna 0.3410140351384347 0.18492099592974 0.8532910026254483 1.0 1.0 10 Q9Y3B2 1 Met activates ras signaling 0.375996093041483 0.1823936506686418 0.8552738082660138 1.0 1.0 4 Q9NWH9 1 Smooth muscle contraction 0.3299928952994077 0.17797854750234 0.8587398233642032 1.0 1.0 13 P07355,P67936,P06753 3 Leishmania infection 0.3922772598530313 0.177448004574585 0.8591565033495554 1.0 1.0 35 Q16539,P07947,P05067,P09601,Q9UQB8,P10644,P16220 7 Membrane trafficking 0.4534011817779892 0.1747906674014072 0.8612441217829234 1.0 1.0 225 Q10472,O43493,P35606,Q96FZ7,Q9UHD9,Q9NZ09,Q9UIQ6,P60520,P15586,P11717,Q12981,P05067,P09496,O94973,O75976,P01130,Q99523,Q92747,P02786,O14964,Q14108,Q13561,Q9H0U4,Q9Y3P9,O95295,P53634,P98164,Q12907,P61201,P51809,Q9UQN3,P61020,Q96KP1,O95486,P18085,O00139,Q10567,Q9H0H5,O00461,Q10471,P49257,Q9NQT8,Q9Y3E7,Q9Y296,Q9BVA1,P20645,O60499,Q9UNF0,O00471,Q14807,P11233,P84085,P24390 53 Interleukin 4 and interleukin 13 signaling 0.3308861819911421 0.1613998155774808 0.8717785119165486 1.0 1.0 11 P05556 1 Ra biosynthesis pathway 0.3970577567237851 0.1548562621465969 0.8769346353549115 1.0 1.0 3 Q9HBH5 1 Insulin processing 0.3322365616845727 0.1531710903806356 0.8782633551551451 1.0 1.0 9 Q96KP1,O00471 2 L1cam interactions 0.4080116992512839 0.1514358168124013 0.8796319375160029 1.0 1.0 43 P06756,P67870,Q13740,O14786,Q9BVA1,P09496,O00560,P05556 8 Antigen activates b cell receptor bcr leading to generation of second messengers 0.3921768707483046 0.1500249383596552 0.8807449399614558 1.0 1.0 3 O43865,P62993 2 Met activates ptpn11 0.3906991255395501 0.1486120708246393 0.8818597476463288 1.0 1.0 3 Q9NWH9 1 Beta oxidation of butanoyl coa to acetyl coa 0.3901360544217642 0.148079761607007 0.8822798212475889 1.0 1.0 3 Q16836,P40939 2 Mtorc1 mediated signalling 0.3282853126330591 0.147067932033831 0.8830784011395549 1.0 1.0 10 P62942,P06730 2 Atf4 activates genes in response to endoplasmic reticulum stress 0.3220117917264042 0.1419154401973756 0.8871467982437702 1.0 1.0 12 Q9Y3B2 1 Constitutive signaling by aberrant pi3k in cancer 0.3502957249608113 0.1405064374439826 0.8882598666023573 1.0 1.0 5 Q9NWH9 1 Unfolded protein response upr 0.3935996877830133 0.1388167036021173 0.8895949942187409 1.0 1.0 39 P51858,O14773,P43307,Q9Y3B2 4 Perk regulates gene expression 0.3130258122151325 0.1317461362956954 0.8951850920559554 1.0 1.0 14 Q9Y3B2 1 Retrograde neurotrophin signalling 0.3230746202246507 0.1285474037559694 0.8977157865974195 1.0 1.0 9 P09496,O94973,Q96CW1 3 Complex i biogenesis 0.3683152816211993 0.1213956467748427 0.90337766475182 1.0 1.0 32 Q9NPL8,O43674,P03886,Q7L592,Q9NX14,O14561,O95298,Q9Y6M9,Q16795,O75438,O96000,Q86Y39,P51970 13 Diseases associated with n glycosylation of proteins 0.3482993197278932 0.1171911389240724 0.906708588648594 1.0 1.0 3 Q13724,O75340 2 Interleukin 1 family signaling 0.3983007416119395 0.1146340615182004 0.908735180479568 1.0 1.0 43 P28070,Q13616,Q13501,P05067,P28072,P20618,P49721 7 Selective autophagy 0.3563665502257812 0.1118321401527596 0.9109565032048847 1.0 1.0 29 Q9NS69,Q8N4H5,P67870,Q13501,P21796 5 Sema4d in semaphorin signaling 0.3260253605247985 0.1115414198264237 0.9111870222311826 1.0 1.0 7 P35579,P61586,Q9NWH9 3 Metabolism of vitamins and cofactors 0.4007703405881673 0.1035056940648441 0.9175616305591956 1.0 1.0 45 P11166,P43490,P41440,O75874,Q07954,P01130,P98164 7 Inlb mediated entry of listeria monocytogenes into host cell 0.3254771732622845 0.1004685513184133 0.9199723488951904 1.0 1.0 6 O14964,P62993,Q9NWH9 3 Uptake and function of diphtheria toxin 0.2953385505273857 0.094761587685467 0.9245041981105342 1.0 1.0 4 Q16881,P08238,P07900 3 Gap junction degradation 0.3044757216520954 0.0833539622776172 0.9335700938446972 1.0 1.0 5 P09496 1 Cyclin d associated events in g1 0.3043678746549737 0.0831045686709783 0.933768393141108 1.0 1.0 9 Q00534 1 Dna methylation 0.2705001701258877 0.0820187470782141 0.934631805668739 1.0 1.0 4 Q96T88,P16104,P26358 3 Dcc mediated attractive signaling 0.4304658279496824 0.0759329346156674 0.9394724544549504 1.0 1.0 2 P63000 1 Acyl chain remodelling of pg 0.4284257055423389 0.0755797615025695 0.9397534383830022 1.0 1.0 2 Q92604 1 Sars cov infections 0.4360143946554872 0.0749384551130924 0.9402636798064654 1.0 1.0 62 Q10472,Q96FZ7,Q9UQN3,P15260,Q99720,P05026,P05556,P62942,Q92769,P54709 10 Copii mediated vesicle transport 0.3446167622973167 0.0727288125878543 0.9420219201277416 1.0 1.0 29 P54920,Q13190,Q9Y6B6,Q9Y296,O95486,P49755,Q9H0U4,P53634,P49257,Q12907 10 Erbb2 regulates cell motility 0.3944236654199291 0.0713776321843775 0.9430972111266496 1.0 1.0 2 P61586 1 Role of lat2 ntal lab on calcium mobilization 0.3920435226113554 0.0711813266243786 0.943253442908949 1.0 1.0 2 P62993 1 Platelet sensitization by ldl 0.303888723023623 0.0706798498269331 0.9436525582309808 1.0 1.0 6 Q16539 1 Autophagy 0.403152817090742 0.0634709544554552 0.9493914875818364 1.0 1.0 50 Q9NS69,Q8N4H5,Q96FZ7,P67870,P60520,Q9UQN3,Q13501,Q9BVA1,P21796,P13473 10 Gamma carboxylation hypusine formation and arylsulfatase activation 0.2956403269754805 0.0586303114113317 0.9532465671884928 1.0 1.0 7 Q9H2P9,P38435,O43681,P63241,O60725,Q9BU89 6 Factors involved in megakaryocyte development and platelet production 0.3673201042611158 0.0564268459691796 0.9550017710297788 1.0 1.0 38 Q9NQT8,Q9BVA1,O00139,Q9H0H5,P45973,Q14807,Q96ST3,Q92769,P10644 9 Pkmts methylate histone lysines 0.2913379899614389 0.0554172023440887 0.9558060914076504 1.0 1.0 9 Q15291 1 Ctla4 inhibitory signaling 0.290481546082904 0.0511611008912416 0.9591971482213096 1.0 1.0 7 P07947 1 Association of tric cct with target proteins during biosynthesis 0.3001903963146594 0.0499332157562825 0.9601756079630046 1.0 1.0 18 P04062 1 Cyclin a b1 b2 associated events during g2 m transition 0.2876314356965896 0.0481453125536347 0.9616004338587528 1.0 1.0 9 Q9Y570,P53350 2 Conversion from apc c cdc20 to apc c cdh1 in late anaphase 0.2848381601362871 0.0454607289334344 0.9637400762881504 1.0 1.0 8 Q9H1A4,Q9UJX2,Q96DE5,Q9UJX6,Q16763,P30260,Q9UJX4 7 Aberrant regulation of mitotic exit in cancer due to rb1 defects 0.2849352419904569 0.0430241150068041 0.9656823106534564 1.0 1.0 9 Q13309,Q9H1A4,Q9UJX2,Q96DE5,Q9UJX6,Q16763,P30260,Q9UJX4 8 Activation of anterior hox genes in hindbrain development during early embryogenesis 0.2829869362161932 0.0421933299288234 0.9663445797726896 1.0 1.0 14 Q15291 1 Sema4d induced cell migration and growth cone collapse 0.2291195020929033 0.0413679424165575 0.9670025691558176 1.0 1.0 5 P35579,P61586 2 Regulation of tp53 activity through phosphorylation 0.326517627234752 0.0372550254170356 0.9702816650954248 1.0 1.0 27 Q9UQ84,Q14191,P67870,Q92804 4 Phospholipid metabolism 0.360418611982328 0.0342797697577319 0.9726540567821842 1.0 1.0 38 Q9BTU6,Q8N9F7,P67870,Q8NCC3,P48651,O14735,Q6P1A2,Q13614,Q8IV08 9 Mitochondrial biogenesis 0.3473353941169895 0.0319644982661664 0.9745003627006614 1.0 1.0 34 P48735,Q16539,P56385,Q9BUR5,Q9Y512,P16220 6 Disassembly of the destruction complex and recruitment of axin to the membrane 0.2611508341845407 0.030502340048015 0.9756664271624448 1.0 1.0 6 Q16537,P35222,P48729,P30153,P30154 5 Signaling by ctnnb1 phospho site mutants 0.2611508341845407 0.030502340048015 0.9756664271624448 1.0 1.0 6 Q16537,P35222,P48729,P30153,P30154 5 Beta catenin phosphorylation cascade 0.2611508341845407 0.030502340048015 0.9756664271624448 1.0 1.0 6 Q16537,P35222,P48729,P30153,P30154 5 Platelet homeostasis 0.2791983137517615 0.0302162280963885 0.975894606291528 1.0 1.0 10 Q16539,P20020 2 Negative regulation of met activity 0.273662492394441 0.0297592787233925 0.9762590352421324 1.0 1.0 7 O14964,P62993,Q9NWH9 3 Transport of small molecules 0.525146726770047 0.027143760327669 0.9783450719114964 1.0 1.0 147 Q93050,P35613,P09601,P61916,P01130,P02786,O00400,P05026,P28072,Q9C0H2,Q9BUN8,P51790,Q15904,O15118,Q9H2J7,P21796,Q8WTV0,Q8TB61,Q9NQ11,Q96QD8,P54709,P08183,P11166,P30825,P27105,P51798,P38571,P49721,P08195,Q8N4V1 30 E3 ubiquitin ligases ubiquitinate target proteins 0.2840320332168753 0.0260293942404495 0.9792338931761624 1.0 1.0 16 Q9BUN8,P04439 2 Foxo mediated transcription 0.2746021037682095 0.0247069366336477 0.9802887221371634 1.0 1.0 9 Q96ST3 1 Ros and rns production in phagocytes 0.2717576682522382 0.0241055035790627 0.980768453378052 1.0 1.0 8 Q93050 1 Rho gtpases activate cit 0.2695610490821505 0.0165193195370127 0.9868200894289004 1.0 1.0 9 O43663,P35579,P61586,O14974 4 Inhibition of dna recombination at telomere 0.2708049113233207 0.0126085395896267 0.9899401074735608 1.0 1.0 11 Q9UER7,P62805,P19387,P52434,P19388,P24928,P62875,P16104,Q9NYB0,P30876 10 Signaling by wnt in cancer 0.254173764906301 0.0002725575077528 0.9997825305753256 1.0 1.0 8 P56545,Q16537,P35222,P48729,P30153,P30154,Q14738 7