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interpro_active_site/advanced/idx2term.json

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+{}

interpro_active_site/basic/idx2term.json

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+{}

interpro_active_site/consensus.joblib

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+version https://git-lfs.github.com/spec/v1
+oid sha256:0de2e4ccd59f49603de10507e19240fbeb04c87cf919a35bddc13b2c8fa76b01
+size 75305

interpro_active_site/df_merge.tsv

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+term	overlap	setsize	score	pval	overlap_mean	setsize_mean	score_mean	pval_mean	overlap_std	setsize_std	score_std	pval_std	pval_hit	pval_50	pval_100	pval_250	pval_500

interpro_active_site/metrics.json

@@ -0,0 +1,7 @@
+{
+    "type_of_task": "ranksum",
+    "signature_size": 3162,
+    "annotations_size": 56,
+    "title": "Average number of proteins per term",
+    "value": 2.517857142857143
+}

interpro_active_site/paths.json

@@ -0,0 +1 @@
+{"results_path": "results/proteins/hek293t_core/interpro_active_site/fragment/C246/C246_val_log2fc"}

interpro_active_site/result.tsv

@@ -0,0 +1,3 @@
+Term	es	nes	pval	sidak	fdr	geneset_size	leading_edge	leading_edge_size
+Histidine acid phosphatase active site [IPR033379]	0.9231012658227844	1.6374431266575606	0.1015379132694906	0.9975112211500862	0.2992696391100778	2	Q9NPH0	1
+Serine carboxypeptidase, serine active site [IPR018202]	0.8344412788857213	1.2763619872176708	0.2018275871314867	0.999996708332636	0.4347055722832022	3	Q9HB40,P10619	2

interpro_active_site/selections.json

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+{"all_annotations": ["ATP synthase, F0 complex, subunit A, active site [IPR023011]", "ATP-citrate lyase/succinyl-CoA ligase, active site [IPR017440]", "ATP:guanido phosphotransferase active site [IPR022415]", "ATPase, alpha/beta subunit, nucleotide-binding domain, active site [IPR020003]", "Adenosine/AMP deaminase active site [IPR006650]", "Adenylosuccinate synthase,  active site [IPR033128]", "Beta-ketoacyl synthase, active site [IPR018201]", "Citrate synthase active site [IPR019810]", "ClpP, Ser active site [IPR018215]", "ClpP, histidine active site [IPR033135]", "Cysteine peptidase, asparagine active site [IPR025661]", "Cysteine peptidase, cysteine active site [IPR000169]", "Cysteine peptidase, histidine active site [IPR025660]", "DNA methylase, C-5 cytosine-specific, active site [IPR018117]", "DNA topoisomerase I, active site [IPR018521]", "DNA topoisomerase, type IA, active site [IPR023406]", "DNA/RNA non-specific endonuclease, active site [IPR018524]", "Ferrochelatase, active site [IPR019772]", "Glucose-6-phosphate dehydrogenase, active site [IPR019796]", "Glyceraldehyde 3-phosphate dehydrogenase, active site [IPR020830]", "Glycoside hydrolase, family 2, active site [IPR023232]", "Glycosyl hydrolases family 31, active site [IPR030458]", "Histidine acid phosphatase active site [IPR033379]", "Hydroxymethylglutaryl-CoA lyase, active site [IPR000138]", "Hydroxymethylglutaryl-coenzyme A synthase, active site [IPR000590]", "L-lactate dehydrogenase, active site [IPR018177]", "Leu/Phe/Val dehydrogenases active site [IPR033524]", "Lipase, GDXG, putative serine active site [IPR033140]", "Malate dehydrogenase, active site [IPR001252]", "Nucleoside diphosphate kinase, active site [IPR023005]", "Orotidine 5'-phosphate decarboxylase, active site [IPR018089]", "Peptidase S16, active site [IPR008268]", "Peptidase S26A, signal peptidase I, serine active site [IPR019756]", "Peptidase S8, subtilisin, His-active site [IPR022398]", "Peptidase S8, subtilisin, Ser-active site [IPR023828]", "Peptidase S9, serine active site [IPR002471]", "Peptidase family C14A, His active site [IPR016129]", "Peptidase family C14A, cysteine active site [IPR033139]", "Phosphoglycerate/bisphosphoglycerate mutase, active site [IPR001345]", "Phosphoribosylglycinamide formyltransferase, active site [IPR001555]", "Protein-tyrosine phosphatase, active site [IPR016130]", "Pyridine nucleotide-disulphide oxidoreductase, class I, active site [IPR012999]", "Pyruvate kinase, active site [IPR018209]", "Ribonucleotide reductase small subunit, acitve site [IPR030475]", "Serine carboxypeptidase, serine active site [IPR018202]", "Serine carboxypeptidases, histidine active site [IPR033124]", "Serine/threonine-protein kinase, active site [IPR008271]", "Thermonuclease active site [IPR002071]", "Thiolase, active site [IPR020610]", "Thiolase, acyl-enzyme intermediate active site [IPR020615]", "Thymidylate synthase, active site [IPR020940]", "Transaldolase, active site [IPR018225]", "Triosephosphate isomerase, active site [IPR020861]", "Tyrosine-protein kinase, active site [IPR008266]", "Ubiquitin-activating enzyme E1, Cys active site [IPR033127]", "Ubiquitin-conjugating enzyme, active site [IPR023313]"], "available_proteins": ["ACAA1", "ACAA2", "ACAT1", "ACAT2", "ACLY", "ACP2", "ACP6", "ADA", "ADSS", "APEH", "ATP5A1", "ATP5B", "ATP6", "ATP6V1A", "ATP6V1B2", "AURKA", "AURKB", "BLMH", "CAPN1", "CASP2", "CASP3", "CASP7", "CDK1", "CDK11B", "CDK12", "CDK13", "CDK2", "CDK4", "CDK5", "CDK6", "CDK9", "CKB", "CKMT1A*", "CLPP", "CPVL", "CS", "CSK", "CSNK1A1", "CSNK2A2", "CTSA", "CTSB", "DLD", "DNMT1", "DUSP3", "EIF2AK2", "ENDOG", "EPHA7", "FASN", "FECH", "G6PD", "GAA", "GAK", "GANAB", "GAPDH", "GART", "GLUD1", "GSK3A", "GSK3B", "GSR", "GUSB", "HADHB", "HMGCL", "HMGCS1", "IGF1R", "LDHA", "LDHB", "LONP1", "LYN", "MAPK1", "MAPK3", "MARK2", "MASTL", "MDH1", "MDH2", "NCEH1", "NEK9", "NME1", "NME3", "PAK1", "PAK2", "PBK", "PGAM1", "PIK3R4", "PKM", "PKMYT1", "PKN2", "PLK1", "PREP", "PRKAA1", "PRKACA", "PRKCD", "PRPF4B", "PTK7", "PTPN1", "PTPN11", "PTPRF", "ROCK1", "ROCK2", "RPS6KA1", "RPS6KA3", "RRM2", "SCP2", "SCPEP1", "SEC11A", "SLK", "SND1", "SRC", "SRPK1", "SUCLG1", "TALDO1", "TIGAR", "TOP1", "TOP3A", "TPI1", "TPP2", "TXNRD1", "TYMS", "UBA1", "UBA2", "UBA3", "UBE2G2", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2S", "UMPS", "VRK1", "WNK1"], "leading_proteins": ["ACP6", "CTSA", "SCPEP1"]}

interpro_binding_site/advanced/idx2term.json

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+{"0": "EF-Hand 1, calcium-binding site [IPR018247]"}

interpro_binding_site/basic/idx2term.json

@@ -0,0 +1 @@
+{"0": "EF-Hand 1, calcium-binding site [IPR018247]"}

interpro_binding_site/consensus.joblib

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+version https://git-lfs.github.com/spec/v1
+oid sha256:a347bd153e43a7b48c4b9168a2e471f88e07caf53b0305a86a2c2b1bc5c36619
+size 72681

interpro_binding_site/df_merge.tsv

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+term	overlap	setsize	score	pval	overlap_mean	setsize_mean	score_mean	pval_mean	overlap_std	setsize_std	score_std	pval_std	pval_hit	pval_50	pval_100	pval_250	pval_500
+EF-Hand 1, calcium-binding site [IPR018247]	9	36	2.121307719119511	0.0338959152090492	10.019417475728156	36.70631067961165	0.9532938980945532	0.3894555773109194	3.76037227687173	3.057484685571999	1.1082350706804749	0.3408841825650379	0.0003740839835305	0.3175327074700926	0.1703695790625126	0.0116807824112378	0.0014057503196826

interpro_binding_site/metrics.json

@@ -0,0 +1,7 @@
+{
+    "type_of_task": "ranksum",
+    "signature_size": 3162,
+    "annotations_size": 29,
+    "title": "Average number of proteins per term",
+    "value": 4.448275862068965
+}

interpro_binding_site/paths.json

@@ -0,0 +1 @@
+{"results_path": "results/proteins/hek293t_core/interpro_binding_site/fragment/C246/C246_val_log2fc"}

interpro_binding_site/result.tsv

@@ -0,0 +1,3 @@
+Term	es	nes	pval	sidak	fdr	geneset_size	leading_edge	leading_edge_size
+EF-Hand 1, calcium-binding site [IPR018247]	0.4935845355303585	2.121307719119511	0.0338959152090492	0.6321306267984474	0.1404259344374896	36	Q14257,O75340,Q02818,Q6NUK1,P80303,O95202,Q9BRK5,Q9NWM8,Q9Y680	9
+Peptidase M16, zinc-binding site [IPR001431]	0.7804620306137604	1.8078444467331471	0.0706307139639306	0.880474338371739	0.2049212445990217	5	P22695	1

interpro_binding_site/selections.json

@@ -0,0 +1 @@
+{"all_annotations": ["2-oxo acid dehydrogenase, lipoyl-binding site [IPR003016]", "2Fe-2S ferredoxin, iron-sulphur binding site [IPR006058]", "6-phosphogluconate-binding site [IPR006184]", "AP endonuclease 1, binding site [IPR020847]", "Aconitase family, 4Fe-4S cluster binding site [IPR018136]", "Adenylosuccinate synthase, GTP-binding site [IPR018220]", "Aminotransferase class-V, pyridoxal-phosphate binding site [IPR020578]", "Aminotransferase, class-II, pyridoxal-phosphate binding site [IPR001917]", "Aminotransferases, class-I, pyridoxal-phosphate-binding site [IPR004838]", "Beta tubulin, autoregulation binding site [IPR013838]", "Biotin-binding site [IPR001882]", "Copper centre Cu(A) [IPR001505]", "Cytochrome b5, heme-binding site [IPR018506]", "Cytochrome c oxidase, subunit Vb, zinc binding site [IPR020893]", "EF-Hand 1, calcium-binding site [IPR018247]", "Fumarate reductase/succinate dehydrogenase, FAD-binding site [IPR003952]", "Hexokinase, binding site [IPR019807]", "IQ motif, EF-hand binding site [IPR000048]", "Inositol monophosphatase, metal-binding site [IPR020583]", "Manganese/iron superoxide dismutase, binding site [IPR019833]", "PPM-type phosphatase, divalent cation binding [IPR000222]", "Peptidase M16, zinc-binding site [IPR001431]", "Peptidase M24A, methionine aminopeptidase, subfamily 2, binding site [IPR018349]", "Porphobilinogen deaminase, dipyrromethane cofactor binding site [IPR022419]", "Protein kinase, ATP binding site [IPR017441]", "RNA polymerases, subunit N, zinc binding site [IPR020789]", "Serine hydroxymethyltransferase, pyridoxal phosphate binding site [IPR019798]", "Sigma-54 interaction domain, ATP-binding site 1 [IPR025662]", "Transketolase binding site [IPR020826]"], "available_proteins": ["ACACA", "ACO2", "ACTN1", "ACTN4", "ADSS", "APEX1", "AURKA", "AURKB", "BPNT1", "CALM3", "CALU", "CAPN1", "CAPNS1", "CDK1", "CDK12", "CDK13", "CDK2", "CDK4", "CDK5", "CDK6", "CDK9", "CETN2", "COX2", "COX5B", "CSK", "CSNK1A1", "CSNK2A2", "CYB5B", "DBT", "DLAT", "DLST", "DST", "EHD1", "EHD4", "EIF2AK2", "EPHA7", "EPS15L1", "FKBP10", "FKBP14", "FKBP7", "FKBP9", "GCAT", "GOT1", "GOT2", "GPD2", "GSK3A", "GSK3B", "HK1", "HK2", "HMBS", "IDE", "IGF1R", "ILKAP", "IQGAP1", "IQGAP2", "LETM1", "LYN", "MACF1", "MAPK1", "MAPK3", "MARK2", "MCCC1", "METAP2", "MICU1", "MYH10", "MYH9", "MYO18A", "MYO1B", "MYO1C", "MYO1D", "NFS1", "NRDC", "NUCB1", "NUCB2", "PA2G4", "PAK1", "PAK2", "PC", "PCCA", "PDCD6", "PDHX", "PEF1", "PGD", "PKMYT1", "PKN2", "PLK1", "PLS3", "PMPCA", "PMPCB", "POLR2L", "PPM1G", "PRKAA1", "PRKACA", "PRKCD", "PRKCSH", "PSAT1", "RAB18", "RCN1", "RCN2", "REPS1", "RHOT1", "RHOT2", "ROCK1", "ROCK2", "RPS6KA1", "RPS6KA3", "S100A11", "SDF4", "SDHA", "SDHB", "SHMT1", "SHMT2", "SLC25A12", "SLC25A24", "SLK", "SOD2", "SPTAN1", "SPTLC2", "SRC", "SRI", "SRPK1", "TKT", "TUBB", "TUBB2A", "TUBB2B", "TUBB6", "UBE3C", "UQCRC2", "VRK1"], "leading_proteins": ["FKBP14", "FKBP7", "LETM1", "NUCB1", "NUCB2", "PDCD6", "RCN2", "SDF4", "SLC25A24", "UQCRC2"]}

interpro_conserved_site/advanced/idx2term.json

@@ -0,0 +1 @@
+{"0": "Syntaxin/epimorphin, conserved site [IPR006012]"}

interpro_conserved_site/basic/idx2term.json

@@ -0,0 +1 @@
+{"0": "Syntaxin/epimorphin, conserved site [IPR006012]", "1": "Intermediate filament protein, conserved site [IPR018039]"}

interpro_conserved_site/consensus.joblib

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+version https://git-lfs.github.com/spec/v1
+oid sha256:e7e9cf8896fd89f4716a90846a785834bd1a419d3842244ef4d3b1a1531e144d
+size 90695

interpro_conserved_site/df_merge.tsv

@@ -0,0 +1,2 @@
+term	overlap	setsize	score	pval	overlap_mean	setsize_mean	score_mean	pval_mean	overlap_std	setsize_std	score_std	pval_std	pval_hit	pval_50	pval_100	pval_250	pval_500
+Syntaxin/epimorphin, conserved site [IPR006012]	7	9	2.2978346001177368	0.0215712046790788	2.592233009708738	5.847087378640777	0.9961908981999794	0.2839139128702306	1.4759357288864456	1.4239341993278547	1.138258151200134	0.2914162845337057	0.0007878725271799	0.0607401038440192	0.0063961411835862	0.003279014583115	0.0002434795729679

interpro_conserved_site/metrics.json

@@ -0,0 +1,7 @@
+{
+    "type_of_task": "ranksum",
+    "signature_size": 3162,
+    "annotations_size": 284,
+    "title": "Average number of proteins per term",
+    "value": 2.6232394366197185
+}

interpro_conserved_site/paths.json

@@ -0,0 +1 @@
+{"results_path": "results/proteins/hek293t_core/interpro_conserved_site/fragment/C246/C246_val_log2fc"}

interpro_conserved_site/result.tsv

@@ -0,0 +1,34 @@
+Term	es	nes	pval	sidak	fdr	geneset_size	leading_edge	leading_edge_size
+Syntaxin/epimorphin, conserved site [IPR006012]	0.7582568044391365	2.2978346001177368	0.0215712046790788	0.9979568508882374	0.1743548388980439	9	P56962,Q9P2W9,O15400,Q12846,O43752,Q13277,O60499	7
+Quinone oxidoreductase/zeta-crystallin, conserved site [IPR002364]	0.8520616601317426	1.8944398163611451	0.0581666556649855	0.9999999593899424	0.2544269614152262	4	Q8N4Q0	1
+Haem oxygenase conserved site [IPR018207]	0.9765822784810124	1.8645053336529545	0.0622507732659536	0.9999999881797416	0.2562205740221859	2	P09601	1
+Intermediate filament protein, conserved site [IPR018039]	0.6988906497622862	1.7650503160525064	0.0775553097160199	0.999999999889578	0.2936761061246623	7	P48681,P07196,Q03252,P08670,Q16352,P20700	6
+Mini-chromosome maintenance, conserved site [IPR018525]	0.6954900510551414	1.5831162799109642	0.113394963655754	0.9999999999999986	0.3538919744860896	6	Q14566	1
+Lysosome-associated membrane glycoprotein, conserved site [IPR018134]	0.9022151898734174	1.5483266416869668	0.1215436732477193	1.0	0.363262068268523	2	P11279	1
+Sugar transporter, conserved site [IPR005829]	0.8696202531645563	1.4090909506720872	0.1588082763349108	1.0	0.4215098175618193	2	P11166	1
+Tetraspanin, conserved site [IPR018503]	0.8465357564984177	1.325081078439201	0.1851442611782445	1.0	0.4381747514551788	3	O60637	1
+Proteasome beta-type subunit, conserved site [IPR016050]	0.5640496906756505	1.3181126592964476	0.1874659373353631	1.0	0.4400026958945712	8	P28070,P49721,P28072,P28074	4
+Sterol reductase, conserved site [IPR018083]	0.8210353408055568	1.222413707058335	0.2215512183591437	1.0	0.4785490447943916	3	O76062	1
+AMP-binding, conserved site [IPR020845]	0.6071722835396653	1.1650920310128343	0.2439817422344785	1.0	0.510821224200738	6	Q96CM8	1
+Guanylate kinase, conserved site [IPR020590]	0.5765391383972066	1.159095449128417	0.2464172806883842	1.0	0.510821224200738	7	Q92796,Q14168,Q9NZW5,O14936	4
+ABC transporter-like, conserved site [IPR017871]	0.4537751275552384	0.9877778201418138	0.3232614723852371	1.0	0.603988540509259	14	P33527,P08183,Q03518,O75027	4
+DnaJ domain, conserved site [IPR018253]	0.5045559786903974	0.9754073600068048	0.3293582342700527	1.0	0.6113577681875489	9	Q96KC8	1
+Glycoside hydrolase, family 29, conserved site [IPR018526]	0.7636075949367077	0.9615682332018012	0.3362665350648239	1.0	0.6175115260229521	2	P04066	1
+Short-chain dehydrogenase/reductase, conserved site [IPR020904]	0.4967118284442627	0.9114614446607836	0.3620522913712347	1.0	0.6426428171839417	10	Q06136,Q8NBN7	2
+Apoptosis regulator, Bcl-2, BH3 motif, conserved site [IPR020728]	0.7256329113924037	0.8073127453661835	0.4194863228038004	1.0	0.6886365067993024	2	Q07820	1
+Apoptosis regulator, Bcl-2, BH2 motif, conserved site [IPR020726]	0.7256329113924037	0.8073127453661835	0.4194863228038004	1.0	0.6886365067993024	2	Q07820	1
+Apoptosis regulator, Bcl-2, BH1 motif, conserved site [IPR020717]	0.7256329113924037	0.8073127453661835	0.4194863228038004	1.0	0.6886365067993024	2	Q07820	1
+Thioredoxin, conserved site [IPR017937]	0.4399468823090498	0.7462101189161952	0.4555404964417819	1.0	0.7108434120300333	12	Q9H1E5,Q9H3N1	2
+Alpha-D-phosphohexomutase, conserved site [IPR016066]	0.6833320412492216	0.6839009225069606	0.494037731472281	1.0	0.7331054373682914	3	P36871	1
+Actin/actin-like conserved site [IPR020902]	0.6384931940487456	0.523172785487279	0.6008540180470963	1.0	0.7936775880057244	3	P61158,P61160	2
+Acyl-CoA-binding protein, ACBP, conserved site [IPR022408]	0.5748455316266032	0.3201641299869288	0.7488439132706382	1.0	0.86804763824025	3	Q5T8D3	1
+Heat shock protein Hsp90, conserved site [IPR019805]	0.5527065527065471	0.2587424721146071	0.795833947118171	1.0	0.8864173793324016	3	P14625,P07900	2
+4Fe-4S ferredoxin, iron-sulphur binding, conserved site [IPR017900]	0.5471397404236973	0.2441699508727351	0.8070991985576474	1.0	0.8884347767068678	3	P21912	1
+Clathrin adaptor, mu subunit, conserved site [IPR018240]	0.4878125989237025	0.1129001899111997	0.9101096857670804	1.0	0.9573005583624108	3	Q9Y2T2,Q9BXS5	2
+Actin, conserved site [IPR004001]	0.4680379746835414	0.0768961338805276	0.9387061731587611	1.0	0.9783993069380345	2	P61163	1
+Annexin repeat, conserved site [IPR018252]	0.3649033892936381	0.0746369690009062	0.9405035591340964	1.0	0.9783993069380345	5	P50995,P08133,P20073,P04083	4
+Calreticulin/calnexin, conserved site [IPR018124]	0.4585316037762248	0.0651937446575853	0.9480197415754784	1.0	0.9826190022169192	3	P27824	1
+Cyclic nucleotide-binding, conserved site [IPR018488]	0.4249999999999971	0.0358678327135786	0.9713877451309784	1.0	0.9979574596502948	2	P10644	1
+Thiosulphate sulfurtransferase, conserved site [IPR001307]	0.4145569620253135	0.028988388488378	0.9768738513478236	1.0	0.9979574596502948	2	P25325	1
+Ribosomal protein S9, conserved site [IPR020574]	0.3734177215189844	0.0108741130305443	0.991323884087324	1.0	1.0	2	P82933	1
+Histidine triad, conserved site [IPR019808]	0.3053797468354396	0.000530214396061	0.9995769501392892	1.0	1.0	2	Q96C86	1

interpro_conserved_site/selections.json

@@ -0,0 +1 @@
+{"all_annotations": ["14-3-3 protein, conserved site [IPR023409]", "3-hydroxyacyl-CoA dehydrogenase, conserved site [IPR006180]", "3-hydroxyisobutyrate dehydrogenase-related, conserved site [IPR002204]", "4Fe-4S ferredoxin, iron-sulphur binding, conserved site [IPR017900]", "ABC transporter-like, conserved site [IPR017871]", "AMP-binding, conserved site [IPR020845]", "AP endonuclease 1, conserved site [IPR020848]", "AT hook, DNA-binding motif [IPR017956]", "ATP synthase, F1 complex, gamma subunit conserved site [IPR023632]", "ATP-citrate lyase/succinyl-CoA ligase, conserved site [IPR033847]", "ATP-dependent RNA helicase DEAD-box, conserved site [IPR000629]", "ATPase, AAA-type, conserved site [IPR003960]", "ATPase, OSCP/delta subunit, conserved site [IPR020781]", "Acin1, RNSP1-SAP18 binding (RSB) motif [IPR032552]", "Actin, conserved site [IPR004001]", "Actin/actin-like conserved site [IPR020902]", "Actinin-type actin-binding domain, conserved site [IPR001589]", "Acyl-CoA dehydrogenase, conserved site [IPR006089]", "Acyl-CoA-binding protein, ACBP, conserved site [IPR022408]", "Adenylate kinase, conserved site [IPR033690]", "Alanine dehydrogenase/NAD(P) transhydrogenase, conserved site-1 [IPR008142]", "Alanine dehydrogenase/pyridine nucleotide transhydrogenase, conserved site-2 [IPR008143]", "Alcohol dehydrogenase, zinc-type, conserved site [IPR002328]", "Aldehyde dehydrogenase, cysteine active site [IPR016160]", "Aldehyde dehydrogenase, glutamic acid active site [IPR029510]", "Aldo/keto reductase, conserved site [IPR018170]", "Aldose 1-epimerase, conserved site [IPR018052]", "Alpha-D-phosphohexomutase, conserved site [IPR016066]", "Aminoacyl-tRNA synthetase, class I, conserved site [IPR001412]", "Aminotransferase, class IV, conserved site [IPR018300]", "Amyloidogenic glycoprotein,  copper-binding domain conserved site [IPR019744]", "Amyloidogenic glycoprotein, intracellular domain, conserved site [IPR019745]", "Anion exchange, conserved site [IPR018241]", "Annexin repeat, conserved site [IPR018252]", "Apoptosis regulator, Bcl-2, BH1 motif, conserved site [IPR020717]", "Apoptosis regulator, Bcl-2, BH2 motif, conserved site [IPR020726]", "Apoptosis regulator, Bcl-2, BH3 motif, conserved site [IPR020728]", "ArgE/DapE/ACY1/CPG2/YscS, conserved site [IPR001261]", "BUD31/G10-related, conserved site [IPR018230]", "Bacterial Fmu (Sun)/eukaryotic nucleolar NOL1/Nop2p, conserved site [IPR018314]", "Band 7/stomatin-like, conserved site [IPR018080]", "Bromodomain, conserved site [IPR018359]", "C-type lectin, conserved site [IPR018378]", "CAMSAP, spectrin and Ca2+/calmodulin-binding region [IPR031372]", "CAP, conserved site, C-terminal [IPR028417]", "CAP, conserved site, N-terminal [IPR018106]", "CBX family C-terminal motif [IPR033773]", "Cadherin conserved site [IPR020894]", "Calreticulin/calnexin, conserved site [IPR018124]", "Carbohydrate/purine kinase, PfkB, conserved site [IPR002173]", "Chaperonin Cpn60, conserved site [IPR018370]", "Chaperonin GroES, conserved site [IPR018369]", "Chaperonin TCP-1, conserved site [IPR002194]", "Chromo domain, conserved site [IPR023779]", "Clathrin adaptor complex, small chain [IPR000804]", "Clathrin adaptor, mu subunit, conserved site [IPR018240]", "Coproporphyrinogen III oxidase, conserved site [IPR018375]", "Cullin, conserved site [IPR016157]", "Cyclic nucleotide-binding, conserved site [IPR018488]", "Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site [IPR020892]", "Cytochrome P450, conserved site [IPR017972]", "D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site 1 [IPR029752]", "D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site [IPR029753]", "DNA ligase, ATP-dependent, conserved site [IPR016059]", "DNA methylase, C-5 cytosine-specific,  conserved site [IPR031303]", "DNA methylase, N-6 adenine-specific, conserved site [IPR002052]", "DNA mismatch repair, conserved site [IPR014762]", "DNA topoisomerase, type IIA, conserved site [IPR018522]", "DNA-directed DNA polymerase, family A, conserved site [IPR019760]", "DNA-directed DNA polymerase, family B, conserved site [IPR017964]", "DNA-directed RNA polymerase, 30-40kDa subunit, conserved site [IPR001514]", "DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site [IPR002464]", "Di-trans-poly-cis-decaprenylcistransferase-like, conserved site [IPR018520]", "Dihydrofolate reductase conserved site [IPR017925]", "Dihydroorotase, conserved site [IPR002195]", "DnaJ domain, conserved site [IPR018253]", "Dpy-30 motif [IPR007858]", "Dynamin, GTPase region, conserved site [IPR019762]", "Dynein light chain, type 1/2, conserved site [IPR019763]", "EGF-like calcium-binding, conserved site [IPR018097]", "EGF-like, conserved site [IPR013032]", "Electron transfer flavoprotein subunit alpha, conserved site [IPR018206]", "Electron transfer flavoprotein, beta-subunit, conserved site [IPR000049]", "Endonuclease III-like, conserved site-2 [IPR004036]", "Endonuclease III-like, iron-sulphur cluster loop motif [IPR003651]", "Enolase, conserved site [IPR020809]", "Enoyl-CoA hydratase/isomerase, conserved site [IPR018376]", "Ependymin, conserved site [IPR018224]", "Eukaryotic translation initiation factor 4E (eIF-4E), conserved site [IPR019770]", "F-actin capping protein, alpha subunit, conserved site [IPR017865]", "F-actin capping protein, beta subunit, conserved site [IPR019771]", "FERM conserved site [IPR019747]", "FLAP/GST2/LTC4S, conserved site [IPR018295]", "Fatty acid desaturase type 1, conserved site [IPR001522]", "Fibrillarin, conserved site [IPR020813]", "Formate-tetrahydrofolate ligase, FTHFS, conserved site [IPR020628]", "Fructose-bisphosphate aldolase class-I active site [IPR029768]", "Fumarate lyase, conserved site [IPR020557]", "GHMP kinase, ATP-binding, conserved site [IPR006203]", "GPCR, family 2, secretin-like, conserved site [IPR017983]", "GTP1/OBG, conserved site [IPR006074]", "Galactokinase, conserved site [IPR019741]", "Gamma-glutamyl phosphate reductase GPR, conserved site [IPR020593]", "Glucosamine-6-phosphate isomerase, conserved site [IPR018321]", "Glutamate 5-kinase, conserved site [IPR019797]", "Glutamyl-tRNA(Gln) amidotransferase, subunit B, conserved site [IPR017958]", "Glutathione peroxidase conserved site [IPR029760]", "Glycerate/sugar phosphate transporter, conserved site [IPR021159]", "Glycoside hydrolase family 27/36, conserved site [IPR000111]", "Glycoside hydrolase, family 2, conserved site [IPR023230]", "Glycoside hydrolase, family 29, conserved site [IPR018526]", "Glycoside hydrolase, family 35, conserved site [IPR019801]", "Glycosyl hydrolases family 31, conserved site [IPR030459]", "Glyoxalase I, conserved site [IPR018146]", "Golgin subfamily A member 2, C-terminal binding motif [IPR043937]", "Guanylate kinase, conserved site [IPR020590]", "HIND motif [IPR045347]", "HMG box A DNA-binding domain, conserved site [IPR017967]", "HMG-I/HMG-Y, DNA-binding, conserved site [IPR000637]", "Haem oxygenase conserved site [IPR018207]", "Heat shock protein 70, conserved site [IPR018181]", "Heat shock protein Hsp90, conserved site [IPR019805]", "Heavy-metal-associated, conserved site [IPR017969]", "Helix-hairpin-helix motif [IPR000445]", "Helix-hairpin-helix motif, class 2 [IPR008918]", "Hexapeptide transferase, conserved site [IPR018357]", "Histidine triad, conserved site [IPR019808]", "Histone H2A conserved site [IPR032458]", "Histone H4, conserved site [IPR019809]", "IMP dehydrogenase / GMP reductase, conserved site [IPR015875]", "Immunoglobulin/major histocompatibility complex, conserved site [IPR003006]", "Inositol monophosphatase, conserved site [IPR020550]", "Integrin alpha chain, C-terminal cytoplasmic region, conserved site [IPR018184]", "Intermediate filament protein, conserved site [IPR018039]", "Isocitrate/isopropylmalate dehydrogenase, conserved site [IPR019818]", "Kinesin motor domain, conserved site [IPR019821]", "Lipocalin family conserved site [IPR022272]", "Low-density lipoprotein (LDL) receptor class A, conserved site [IPR023415]", "Lysophospholipase patatin, conserved site [IPR001423]", "Lysosome-associated membrane glycoprotein, conserved site [IPR018134]", "Macrophage migration inhibitory factor, conserved site [IPR019829]", "Malic enzyme, conserved site [IPR015884]", "Methylthiotransferase, conserved site [IPR020612]", "Mini-chromosome maintenance, conserved site [IPR018525]", "Mitogen-activated protein (MAP) kinase, conserved site [IPR003527]", "Mrp, conserved site [IPR000808]", "Myristoyl-CoA:protein N-myristoyltransferase, conserved site [IPR022678]", "NADH:ubiquinone oxidoreductase, 30kDa subunit, conserved site [IPR020396]", "NADH:ubiquinone oxidoreductase, 49kDa subunit, conserved site [IPR014029]", "NADH:ubiquinone oxidoreductase, 51kDa subunit, conserved site [IPR001949]", "NADH:ubiquinone oxidoreductase, 75kDa subunit, conserved site [IPR000283]", "NADH:ubiquinone oxidoreductase, subunit 1, conserved site [IPR018086]", "NUDIX hydrolase, conserved site [IPR020084]", "Oxysterol-binding protein, conserved site [IPR018494]", "P-type trefoil, conserved site [IPR017957]", "Peptidase M22, conserved site [IPR017860]", "Peptidase M24B, X-Pro dipeptidase/aminopeptidase P, conserved site [IPR001131]", "Peptidase S26A, signal peptidase I, conserved site [IPR019758]", "Phosphatidylethanolamine-binding, conserved site [IPR001858]", "Phosphatidylinositol 3/4-kinase, conserved site [IPR018936]", "Phosphoenolpyruvate carboxykinase, GTP-utilising, conserved site [IPR018091]", "Phosphofructokinase, conserved site [IPR015912]", "Phosphoglucose isomerase, conserved site [IPR018189]", "Phosphoglycerate kinase, conserved site [IPR015911]", "Phosphomannose isomerase, type I, conserved site [IPR018050]", "Phosphoribosyl pyrophosphate synthetase, conserved site [IPR000842]", "Phosphoribosylglycinamide synthetase, conserved site [IPR020559]", "Phosphorylase pyridoxal-phosphate attachment site [IPR035090]", "Polyamine biosynthesis domain, conserved site [IPR030373]", "Polyprenyl synthetase, conserved site [IPR033749]", "Procollagen-lysine 5-dioxygenase, conserved site [IPR001006]", "Profilin conserved site [IPR027310]", "Proliferating cell nuclear antigen, PCNA, conserved site [IPR022659]", "Proteasome beta-type subunit, conserved site [IPR016050]", "Protein phosphatase 2A regulatory subunit PR55, conserved site [IPR018067]", "Proteinase inhibitor I2, Kunitz, conserved site [IPR020901]", "Proteinase inhibitor I25, cystatin, conserved site [IPR018073]", "Pseudouridine synthase TruD, conserved site [IPR020119]", "Purine phosphorylase, family 2, conserved site [IPR018099]", "Quinone oxidoreductase/zeta-crystallin, conserved site [IPR002364]", "RNA 3'-terminal phosphate cyclase-like, conserved site [IPR020719]", "RNA polymerase, beta subunit, conserved site [IPR007121]", "RNA polymerase, subunit H/Rpb5, conserved site [IPR020608]", "Ras GTPase-activating protein, conserved site [IPR023152]", "Retro-transposon transporting motif [IPR018892]", "Ribonuclease II/R, conserved site [IPR022966]", "Ribosomal RNA adenine methylase transferase, conserved site [IPR020596]", "Ribosomal S11, conserved site [IPR018102]", "Ribosomal S24e conserved site [IPR018098]", "Ribosomal protein L1, conserved site [IPR023673]", "Ribosomal protein L10e, conserved site [IPR018255]", "Ribosomal protein L11, conserved site [IPR020785]", "Ribosomal protein L13, conserved site [IPR023563]", "Ribosomal protein L13e, conserved site [IPR018256]", "Ribosomal protein L14P,  conserved site [IPR019972]", "Ribosomal protein L15, conserved site [IPR001196]", "Ribosomal protein L15e, conserved site [IPR020925]", "Ribosomal protein L18e, conserved site [IPR021132]", "Ribosomal protein L19/L19e conserved site [IPR023638]", "Ribosomal protein L2, conserved site [IPR022671]", "Ribosomal protein L21e, conserved site [IPR018259]", "Ribosomal protein L22/L17, conserved site [IPR018260]", "Ribosomal protein L23/L25, conserved site [IPR001014]", "Ribosomal protein L24/L26, conserved site [IPR005825]", "Ribosomal protein L24e, conserved site [IPR023442]", "Ribosomal protein L27e, conserved site [IPR018262]", "Ribosomal protein L29, conserved site [IPR018254]", "Ribosomal protein L3, conserved site [IPR019926]", "Ribosomal protein L30, conserved site [IPR018038]", "Ribosomal protein L30e, conserved site [IPR022991]", "Ribosomal protein L31e, conserved site [IPR020052]", "Ribosomal protein L32e, conserved site [IPR018263]", "Ribosomal protein L34e, conserved site [IPR018065]", "Ribosomal protein L35Ae, conserved site [IPR018266]", "Ribosomal protein L37e, conserved site [IPR018267]", "Ribosomal protein L4/L1e, eukaryotic/archaeal, conserved site [IPR013000]", "Ribosomal protein L5, conserved site [IPR020929]", "Ribosomal protein L6, conserved site-2 [IPR002359]", "Ribosomal protein L7Ae conserved site [IPR004037]", "Ribosomal protein S10, conserved site [IPR018268]", "Ribosomal protein S13, conserved site [IPR018269]", "Ribosomal protein S17, conserved site [IPR019979]", "Ribosomal protein S17e, conserved site [IPR018273]", "Ribosomal protein S19 conserved site [IPR020934]", "Ribosomal protein S19e, conserved site [IPR018277]", "Ribosomal protein S2, conserved site [IPR018130]", "Ribosomal protein S21e, conserved site [IPR018279]", "Ribosomal protein S28e conserved site [IPR028626]", "Ribosomal protein S3, conserved site [IPR018280]", "Ribosomal protein S3Ae, conserved site [IPR018281]", "Ribosomal protein S4, conserved site [IPR018079]", "Ribosomal protein S4e, N-terminal, conserved site [IPR018199]", "Ribosomal protein S5, N-terminal, conserved site [IPR018192]", "Ribosomal protein S6e, conserved site [IPR018282]", "Ribosomal protein S7, conserved site [IPR020606]", "Ribosomal protein S8e, conserved site [IPR018283]", "Ribosomal protein S9, conserved site [IPR020574]", "Ribosome maturation protein SBDS, conserved site [IPR018023]", "RidA, conserved site [IPR019897]", "S-adenosyl-L-homocysteine hydrolase, conserved site [IPR020082]", "S-adenosylmethionine synthetase, conserved site [IPR022631]", "S100/Calbindin-D9k, conserved site [IPR001751]", "SAICAR synthetase, conserved site [IPR018236]", "SecY conserved site [IPR030659]", "Serpin, conserved site [IPR023795]", "Short-chain dehydrogenase/reductase, conserved site [IPR020904]", "Sodium:dicarboxylate symporter, conserved site [IPR018107]", "Squalene/phytoene synthase, conserved site [IPR019845]", "Stathmin, conserved site [IPR030514]", "Sterol reductase, conserved site [IPR018083]", "Succinate dehydrogenase, cytochrome b subunit, conserved site [IPR018495]", "Succinyl-CoA synthetase, beta subunit, conserved site [IPR017866]", "Sugar transporter, conserved site [IPR005829]", "Sulfatase, conserved site [IPR024607]", "Syntaxin/epimorphin, conserved site [IPR006012]", "TPP-binding enzyme, conserved site [IPR000399]", "Terpene synthase, conserved site [IPR002365]", "Tetrahydrofolate dehydrogenase/cyclohydrolase, conserved site [IPR020867]", "Tetraspanin, conserved site [IPR018503]", "Thiolase, conserved site [IPR020613]", "Thioredoxin, conserved site [IPR017937]", "Thiosulphate sulfurtransferase, conserved site [IPR001307]", "Thymidine kinase, conserved site [IPR020633]", "Thymidylate kinase, conserved site [IPR018095]", "Tr-type G domain, conserved site [IPR031157]", "Transcription factor TFIIB, conserved site [IPR023486]", "Translation elongation factor EF1B, beta/delta chains, conserved site [IPR001326]", "Translation elongation factor Ts, conserved site [IPR018101]", "Translationally controlled tumour protein, conserved site [IPR018103]", "Tubulin, conserved site [IPR017975]", "Tyrosine-protein kinase, receptor class II, conserved site [IPR002011]", "Tyrosine-protein kinase, receptor class V, conserved site [IPR001426]", "UbiE/COQ5 methyltransferase, conserved site [IPR023576]", "Ubiquitin conserved site [IPR019954]", "Ubiquitin interacting motif [IPR003903]", "Ubiquitin specific protease, conserved site [IPR018200]", "Ubiquitin-activating enzyme E1, conserved site [IPR018074]", "Vinculin, conserved site [IPR000633]", "WD40 repeat, conserved site [IPR019775]", "XPG conserved site [IPR019974]", "YgfZ/GcvT conserved site [IPR017703]", "Zinc finger, PHD-type, conserved site [IPR019786]", "Zinc finger, RING-type, conserved site [IPR017907]", "tRNA-dihydrouridine synthase, conserved site [IPR018517]"], "available_proteins": ["AAAS", "AAMP", "ABCB1", "ABCB10", "ABCB6", "ABCB7", "ABCB8", "ABCC1", "ABCD3", "ABCD4", "ABCE1", "ABCF1", "ABCF2", "ABCF3", "ACAA1", "ACAA2", "ACAD9", "ACADM", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACBD5", "ACIN1", "ACLY", "ACSF2", "ACSL1", "ACSL3", "ACSL4", "ACSL6", "ACTL6A", "ACTN1", "ACTN4", "ACTR1A", "ACTR2", "ACTR3", "ADGRE5", "ADH5", "ADK", "ADSL", "AFG3L2", "AHCY", "AHCYL1", "AK1", "AK2", "AK3", "AK4", "AKR1A1", "AKR1B1", "ALDH18A1", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ANXA1", "ANXA11", "ANXA2", "ANXA6", "ANXA7", "AP1M1", "AP2M1", "AP2S1", "AP3M1", "APEX1", "APP", "ARIH2", "ATAD1", "ATAD2", "ATP5C1", "ATP5O", "ATP7B", "BAG6", "BAX", "BAZ1A", "BAZ1B", "BCAT2", "BCS1L", "BOP1", "BPNT1", "BPTF", "BRCA1", "BRD2", "BRD4", "BUD31", "CAD", "CALR", "CAMSAP3", "CANX", "CAP1", "CAPZA1", "CAPZA2", "CAPZB", "CASK", "CBR1", "CBX1", "CBX2", "CBX3", "CBX5", "CBX8", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CDC40", "CDH2", "CDKAL1", "CECR2", "CETN2", "CHAF1B", "CHD1", "CHD1L", "CHD4", "CLGN", "CMPK1", "CNDP2", "COLEC12", "COPA", "COPZ1", "CORO1B", "CORO1C", "CPOX", "CRYZ", "CSTB", "CSTF1", "CTBP1", "CTBP2", "CTNNA1", "CUL1", "CUL2", "CUL3", "CUL4A", "CUL4B", "CUL5", "CYP51A1", "DCAF7", "DCP2", "DCPS", "DCXR", "DDT", "DDX10", "DDX17", "DDX18", "DDX20", "DDX23", "DDX24", "DDX27", "DDX3X", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX51", "DDX54", "DDX55", "DDX6", "DHCR7", "DHDDS", "DHFR", "DHRS7", "DHRS7B", "DHX15", "DHX16", "DHX29", "DHX30", "DHX36", "DHX38", "DHX40", "DHX57", "DHX8", "DHX9", "DIDO1", "DIS3", "DLG1", "DLG3", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJB11", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC2", "DNAJC9", "DNM1L", "DNM2", "DNMT1", "DPY30", "DRG1", "DRG2", "DSG2", "DST", "DTYMK", "DUS2", "DYNLL1", "DYNLL2", "EARS2", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "EEF1A2", "EEF1B2", "EEF1D", "EEF2", "EHHADH", "EIF3I", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4E", "EIF4E2", "ENO1", "EPB41", "EPB41L2", "EPB41L5", "EPDR1", "EPHA7", "EPRS", "ERCC2", "ETFA", "ETFB", "EXO1", "EZR", "FBL", "FCGRT", "FDFT1", "FDPS", "FEN1", "FH", "FLNA", "FLNB", "FLNC", "FUCA1", "FUCA2", "GAA", "GALK1", "GALM", "GANAB", "GART", "GATB", "GCDH", "GEMIN5", "GFM1", "GLA", "GLB1", "GLO1", "GMPPA", "GMPPB", "GNPDA1", "GNS", "GOLGA2", "GPI", "GPX8", "GRHPR", "GRWD1", "GSPT1", "GTF2B", "GUF1", "GUSB", "H2AFX", "H4C1*", "HADH", "HADHA", "HADHB", "HGS", "HIBADH", "HINT2", "HLA-B", "HLTF", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMOX1", "HMOX2", "HSD17B10", "HSD17B12", "HSD17B4", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA13", "HSPA14", "HSPA1B", "HSPA2", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPD1", "HSPE1", "HSPH1", "HYOU1", "IARS", "IARS2", "IBA57", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDH3G", "IGF1R", "ILVBL", "IMPAD1", "IMPDH2", "INA", "IQGAP1", "IQGAP2", "ITGAV", "IVD", "KDM2A", "KDSR", "KIF11", "KIF14", "KIF18B", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF4A", "KIF5B", "KIFC1", "LAMP1", "LAMP2", "LARS", "LARS2", "LBR", "LDLR", "LIG1", "LIG3", "LMNA", "LMNB1", "LMNB2", "LRWD1", "LSS", "MACF1", "MAPK1", "MAPK3", "MARS", "MAT2A", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "ME1", "ME2", "MGST2", "MID1", "MIF", "MKRN2", "MPHOSPH8", "MPI", "MPP1", "MPP2", "MPP6", "MPP7", "MPST", "MRPL13", "MRPL24", "MRPL3", "MRPS11", "MRPS2", "MRPS5", "MRPS9", "MSN", "MTAP", "MTF2", "MTHFD1", "MTHFD1L", "MTHFD2", "MTOR", "ND1", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS8", "NDUFV1", "NEFL", "NES", "NF2", "NKTR", "NLE1", "NMT1", "NNT", "NOP2", "NSD1", "NSD2", "NSF", "NTHL1", "NUBP2", "NUDT1", "NUDT12", "NUDT5", "NUP153", "NUP37", "NUP43", "NVL", "OSBP", "OSBPL11", "OSBPL1A", "OSBPL8", "OSBPL9", "OSGEP", "P4HB", "PAFAH1B1", "PAICS", "PAK1IP1", "PBRM1", "PCK2", "PCNA", "PDIA3", "PDIA4", "PDIA6", "PEBP1", "PEPD", "PEX6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGK1", "PGM1", "PGM2", "PGM3", "PHF3", "PHGDH", "PHIP", "PI4KA", "PI4KB", "PIK3C2A", "PIK3C3", "PLEC", "PLOD1", "PLOD2", "PLOD3", "PLRG1", "PLS3", "PNP", "PNPLA6", "POLA1", "POLD1", "POLG", "POLR1B", "POLR1C", "POLR2B", "POLR2C", "POLR2E", "PPIB", "PPID", "PPIF", "PPIG", "PPIH", "PPIL1", "PPIL2", "PPP2R2A", "PRKAR1A", "PRKAR2A", "PRKDC", "PRPF19", "PRPF4", "PRPS2", "PSMA4", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD4", "PUS7", "PWP1", "PWP2", "PYGB", "PYGL", "QARS", "RACK1", "RAE1", "RANBP2", "RARS", "RARS2", "RBBP7", "RCL1", "RDH13", "RDX", "RIDA", "RNF14", "RNF20", "RNF40", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL15", "RPL17", "RPL18", "RPL19", "RPL21", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL37", "RPL4", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPS11", "RPS14", "RPS15", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS24", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS8", "RPS9", "RPSA", "RRP8", "RRP9", "RSF1", "RTCA", "RTN4IP1", "S100A11", "SART1", "SBDS", "SCAF11", "SCD", "SCP2", "SDHB", "SDHC", "SEC11A", "SEC61A1", "SERPINB6", "SERPINH1", "SLC1A5", "SLC25A42", "SLC27A4", "SLC2A1", "SLC37A4", "SLC4A2", "SLIT2", "SMARCA4", "SMS", "SMU1", "SNRNP40", "SNU13", "SPATA5", "SPATA5L1", "SPTBN1", "SRCAP", "SRM", "STAM", "STMN1", "STOM", "STRN", "STX10", "STX12", "STX17", "STX18", "STX3", "STX4", "STX5", "STX6", "STX7", "SUCLA2", "SUCLG1", "SUCLG2", "SV2A", "SYNE2", "TAP1", "TAP2", "TBL3", "TCP1", "TFB1M", "THOC6", "TK1", "TLN1", "TM7SF2", "TMX1", "TMX3", "TMX4", "TOP2A", "TOP2B", "TPT1", "TRIM13", "TRIM21", "TRIM24", "TRIM25", "TRIM27", "TRIM28", "TRIP13", "TRMT11", "TSFM", "TSPAN10", "TSPAN3", "TSPAN6", "TST", "TTF2", "TUBB", "TUBB2A", "TUBB2B", "TUBB6", "TUBG1", "TUFM", "TXN2", "TXNDC12", "TXNDC5", "TXNL1", "UBA1", "UBA2", "UHRF1", "USP10", "USP14", "USP19", "USP47", "USP48", "USP5", "USP7", "USP8", "USP9X", "UTP15", "UTP18", "UTRN", "VARS1", "VARS2", "VAT1", "VCL", "VCP", "VIM", "VPS4A", "VPS4B", "WARS", "WARS2", "WDHD1", "WDR1", "WDR12", "WDR18", "WDR3", "WDR36", "WDR41", "WDR5", "WDR61", "WDR77", "XPNPEP1", "YARS2", "YME1L1", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2", "ZMYND8"], "leading_proteins": ["ABCB1", "ABCB7", "ABCC1", "ACBD5", "ACSF2", "ACTR1A", "ACTR2", "ACTR3", "ANXA1", "ANXA11", "ANXA6", "ANXA7", "AP1M1", "AP3M1", "CANX", "CASK", "DCPS", "DLG3", "DNAJC1", "FUCA1", "HMOX1", "HSP90AA1", "HSP90B1", "INA", "KDSR", "LAMP1", "LMNB1", "LMNB2", "MCL1", "MCM6", "MPP2", "MPP6", "MPST", "MRPS9", "NEFL", "NES", "PGM1", "PRKAR1A", "PSMB2", "PSMB4", "PSMB5", "PSMB6", "RDH13", "SDHB", "SLC2A1", "STX10", "STX17", "STX18", "STX3", "STX4", "STX6", "STX7", "TAP1", "TM7SF2", "TMX1", "TMX4", "TSPAN3", "VIM", "ZADH2"]}

interpro_domain/advanced/idx2term.json

@@ -0,0 +1 @@
+{"0": "Band 7 domain [IPR001107]", "1": "EF-hand domain [IPR002048]", "2": "P-type ATPase, haloacid dehalogenase domain [IPR044492]", "3": "Target SNARE coiled-coil homology domain [IPR000727]"}

interpro_domain/basic/idx2term.json

@@ -0,0 +1 @@
+{"0": "Band 7 domain [IPR001107]", "1": "EF-hand domain [IPR002048]", "2": "P-type ATPase, haloacid dehalogenase domain [IPR044492]", "3": "Target SNARE coiled-coil homology domain [IPR000727]", "4": "Intermediate filament, rod domain [IPR039008]", "5": "GOLD domain [IPR009038]", "6": "K Homology domain, type 1 [IPR004088]"}

interpro_domain/consensus.joblib

@@ -0,0 +1,3 @@
+version https://git-lfs.github.com/spec/v1
+oid sha256:d5cfd8dbf8c02a89ee4a1dacce244bbf8305cab36877624b1a4dbf20ffb3de88
+size 290155

interpro_domain/df_merge.tsv

@@ -0,0 +1,10 @@
+term	overlap	setsize	score	pval	overlap_mean	setsize_mean	score_mean	pval_mean	overlap_std	setsize_std	score_std	pval_std	pval_hit	pval_50	pval_100	pval_250	pval_500
+Band 7 domain [IPR001107]	7	8	2.6319464290318835	0.0084897248210809	3.825242718446602	7.354368932038835	0.2848798017769268	0.3662852929750465	1.8717479731706237	0.7075565364256523	1.25010454777189	0.3076860385713043	0.0029583473912349	1.0	1.0	0.018519525655472	1.9890121517705644e-08
+EF-hand domain [IPR002048]	11	41	2.4150816351788955	0.0157316833586802	12.385922330097088	43.512135922330096	1.0171858714399242	0.3947118087831401	4.608360476919044	4.087317384177653	1.201458704248258	0.3652478399429377	0.0001663315239188	0.3837477700868037	0.2425181201499281	0.0102312318313226	0.0010334461262557
+P-type ATPase, haloacid dehalogenase domain [IPR044492]	5	6	2.157534551031373	0.0309640380330336	2.941747572815534	6.145631067961165	0.9567723497044874	0.2732808833570771	1.8358630293390923	1.459204245106796	1.2102525517005158	0.2943240638910574	0.0063012648740632	1.0	1.0	0.0016919334745771	0.0034687949642114
+Aminopeptidase N-like , N-terminal domain [IPR045357]	3	5	2.0835899476462685	0.0371974821667131	2.121359223300971	5.466019417475728	1.4317001483019938	0.1783942022754649	1.021530403905949	0.5881604361499402	0.986353205880356	0.2226891741813114	0.0020239085933755	1.0	1.0	0.1768749528600843	0.0003260526470588
+Peptidase M1, membrane alanine aminopeptidase [IPR014782]	3	5	2.0835899476462685	0.0371974821667131	2.121359223300971	5.466019417475728	1.4317001483019938	0.1783942022754649	1.021530403905949	0.5881604361499402	0.986353205880356	0.2226891741813114	0.0020239085933755	1.0	1.0	0.1768749528600843	0.0003260526470588
+Target SNARE coiled-coil homology domain [IPR000727]	7	11	1.9867888161047869	0.0469458045043238	3.5024271844660193	8.266990291262136	0.5942034778060385	0.4012381903331891	1.9023475359698396	2.183694577914796	1.0582363712887182	0.3038263160802639	0.0538975052559905	0.1135912525516411	0.2108364442764713	0.1203326107508497	0.0062087405568419
+FKBP-type peptidyl-prolyl cis-trans isomerase domain [IPR001179]	2	11	1.981221382490553	0.0475664523207954	3.1262135922330097	10.111650485436892	0.9686720267359892	0.3700536707457866	1.7316562118191232	1.203619216216406	0.9607394322697528	0.3108814801432357	0.0090866710598216	1.0	0.1157837219692003	0.2712176839291556	0.0224777557227792
+Phospholipid/glycerol acyltransferase [IPR002123]	4	5	1.9648922580897117	0.0494267089777891	2.4611650485436893	6.109223300970874	0.4541526786138767	0.3733328307275969	1.647577392422315	1.6678607828333205	1.200305691546449	0.3080828121567173	0.104279305409488	1.0	1.0	0.3225700131084155	0.0395358442373242
+Cytochrome b5-like heme/steroid binding domain [IPR001199]	2	6	1.9616630742334549	0.0498017235927932	2.813106796116505	6.104368932038835	1.6405397264547834	0.1100883340733615	1.2852875686886795	0.8042848477475721	1.100790504333474	0.1612592696854457	0.0627369576937013	0.0014481500629001	0.0054453582128303	0.0323840811666381	0.0179235086559622

interpro_domain/metrics.json

@@ -0,0 +1,7 @@
+{
+    "type_of_task": "ranksum",
+    "signature_size": 3162,
+    "annotations_size": 2574,
+    "title": "Average number of proteins per term",
+    "value": 2.149184149184149
+}

interpro_domain/paths.json

@@ -0,0 +1 @@
+{"results_path": "results/proteins/hek293t_core/interpro_domain/fragment/C246/C246_val_log2fc"}

interpro_domain/result.tsv

@@ -0,0 +1,190 @@
+Term	es	nes	pval	sidak	fdr	geneset_size	leading_edge	leading_edge_size
+Band 7 domain [IPR001107]	0.8249841471147731	2.6319464290318835	0.0084897248210809	0.9999999997055292	0.1585271899559857	8	O94905,Q99623,O75477,Q9UJZ1,P35232,P27105,O75955	7
+EF-hand domain [IPR002048]	0.5136786456639629	2.4150816351788955	0.0157316833586802	1.0	0.1594226494694604	41	Q14257,O75340,Q02818,Q8NF37,Q6NUK1,P80303,O95202,Q9BRK5,P41208,Q9NWM8,Q9Y680	11
+P-type ATPase, haloacid dehalogenase domain [IPR044492]	0.8219264892268652	2.1575345510313735	0.0309640380330336	1.0	0.1958266189116179	6	Q9HD20,P05023,P35670,P16615,P20020	5
+Aminopeptidase N-like , N-terminal domain [IPR045357]	0.8437270446716965	2.0835899476462685	0.0371974821667131	1.0	0.2054642040710722	5	P55786,Q9NZ08,P09960	3
+Peptidase M1, membrane alanine aminopeptidase [IPR014782]	0.8437270446716965	2.0835899476462685	0.0371974821667131	1.0	0.2054642040710722	5	P55786,Q9NZ08,P09960	3
+TRAM/LAG1/CLN8 homology domain [IPR006634]	0.8837872070931015	2.027206583266094	0.0426412901856818	1.0	0.2095532266072924	4	Q96CP7,Q96G23,Q15629	3
+Target SNARE coiled-coil homology domain [IPR000727]	0.6769063208212949	1.9867888161047869	0.0469458045043238	1.0	0.2197063650802355	11	P56962,O15400,Q12846,O43752,O15155,Q13277,O60499	7
+FKBP-type peptidyl-prolyl cis-trans isomerase domain [IPR001179]	0.6758501292333261	1.981221382490553	0.0475664523207954	1.0	0.2202087199167762	11	P62942,Q9Y680	2
+Phospholipid/glycerol acyltransferase [IPR002123]	0.8162812796959151	1.9648922580897117	0.0494267089777891	1.0	0.2252348830878647	5	Q99943,Q8NF37,O15228,Q9HCL2	4
+Cytochrome b5-like heme/steroid binding domain [IPR001199]	0.7779696642267808	1.9616630742334549	0.0498017235927932	1.0	0.2252348830878647	6	O43169,O15173	2
+Alcohol dehydrogenase, N-terminal [IPR013154]	0.7904330032344733	1.8517979811606955	0.0640548376686844	1.0	0.252491810350986	5	Q8N4Q0	1
+Polyketide synthase, enoylreductase domain [IPR020843]	0.7854389661452481	1.8298058360902576	0.0672789778174811	1.0	0.2588581298986494	5	Q8N4Q0	1
+Prenylcysteine lyase [IPR010795]	0.9610759493670884	1.7988887970790766	0.072036273073553	1.0	0.2695078007141361	2	Q9UHG3	1
+Intermediate filament, rod domain [IPR039008]	0.6988906497622862	1.7650503160525064	0.0775553097160199	1.0	0.2796302307682428	7	P48681,P07196,Q03252,P08670,Q16352,P20700	6
+Cation-transporting P-type ATPase, N-terminal [IPR004014]	0.821405953134904	1.7646707773789976	0.0776191126249288	1.0	0.2796302307682428	4	P20020,P16615,P05023	3
+Cation-transporting P-type ATPase, C-terminal [IPR006068]	0.821405953134904	1.7646707773789976	0.0776191126249288	1.0	0.2796302307682428	4	P20020,P16615,P05023	3
+GOLD domain [IPR009038]	0.7319391634980897	1.7520908448130683	0.0797581882685813	1.0	0.2825449118009365	6	Q9BVK6,Q15363,Q9Y3A6,P49755,Q9Y3B3	5
+Peptidase M16, C-terminal [IPR007863]	0.6864676413342541	1.704888908158411	0.0882151454308619	1.0	0.292988108824566	7	Q10713,P22695	2
+Peptidase M16, N-terminal [IPR011765]	0.6864676413342541	1.704888908158411	0.0882151454308619	1.0	0.292988108824566	7	Q10713,P22695	2
+Choline/carnitine acyltransferase domain [IPR039551]	0.9256329113924048	1.6482330623639914	0.0993048546881651	1.0	0.3109619172352034	2	P50416	1
+MENTAL domain [IPR019498]	0.924050632911392	1.6414897161932565	0.1006958000746762	1.0	0.3134111117197299	2	O95772	1
+Phospholipase D/Transphosphatidylase [IPR001736]	0.9142405063291136	1.5996556199397356	0.1096750022968509	1.0	0.3215301320183305	2	Q8IV08	1
+AMP-binding enzyme, C-terminal domain [IPR025110]	0.7815102830243177	1.5938341476189888	0.1109731870297769	1.0	0.3234937524514676	4	Q96CM8	1
+Syntaxin, N-terminal domain [IPR006011]	0.7802406586447186	1.5883651799987273	0.112203786407611	1.0	0.3255129865850609	4	Q12846,O15400,Q13277	3
+LEM domain [IPR003887]	0.7308981739484839	1.5868460505452326	0.1125475161515576	1.0	0.3255129865850609	5	Q86XL3,P50402,P42167	3
+MCM domain [IPR001208]	0.6954900510551414	1.5831162799109642	0.113394963655754	1.0	0.3255129865850609	6	Q14566	1
+MCM N-terminal domain [IPR027925]	0.6954900510551414	1.5831162799109642	0.113394963655754	1.0	0.3255129865850609	6	Q14566	1
+MCM OB domain [IPR033762]	0.6954900510551414	1.5831162799109642	0.113394963655754	1.0	0.3255129865850609	6	Q14566	1
+MCM, AAA-lid domain [IPR041562]	0.6954900510551414	1.5831162799109642	0.113394963655754	1.0	0.3255129865850609	6	Q14566	1
+ABC transporter type 1, transmembrane domain [IPR011527]	0.6120180843638907	1.5354283852647952	0.1246786357185256	1.0	0.3436004371943095	10	P33527,P08183,Q03518,O75027	4
+Endoplasmic reticulum vesicle transporter, N-terminal [IPR039542]	0.8879392212725521	1.491855479681073	0.1357370359951013	1.0	0.3620013466831728	3	Q96RQ1,Q9Y282	2
+Endoplasmic reticulum vesicle transporter, C-terminal [IPR012936]	0.8879392212725521	1.491855479681073	0.1357370359951013	1.0	0.3620013466831728	3	Q96RQ1,Q9Y282	2
+Reticulon [IPR003388]	0.8702120924343117	1.4204839574541628	0.1554668357683732	1.0	0.388139316457607	3	O95197,Q9NQC3	2
+Metaxin, glutathione S-transferase domain [IPR033468]	0.8705696202531641	1.413145578658789	0.1576129241116972	1.0	0.3900026925199646	2	Q13505	1
+Mitochondrial outer membrane transport complex Sam37/metaxin, N-terminal domain [IPR019564]	0.8705696202531641	1.413145578658789	0.1576129241116972	1.0	0.3900026925199646	2	Q13505	1
+Glycerol-3-phosphate acyltransferase-like, C-terminal domain [IPR045520]	0.8667721518987336	1.3969283124538818	0.1624351296430617	1.0	0.3959356285049629	2	Q9HCL2	1
+GPAT/DHAPAT, acyltransferase domain [IPR041728]	0.8667721518987336	1.3969283124538818	0.1624351296430617	1.0	0.3959356285049629	2	Q9HCL2	1
+Syntaxin 6, N-terminal [IPR015260]	0.8626582278481005	1.379363974158695	0.1677825609607843	1.0	0.4057708619170846	2	O60499	1
+ERAP1-like C-terminal domain [IPR024571]	0.8559670781892994	1.363086195135408	0.1728553469764091	1.0	0.4131194643614458	3	P55786,Q9NZ08	2
+Isochorismatase-like [IPR000868]	0.8563291139240499	1.352353421188713	0.1762622824611268	1.0	0.418928084076584	2	Q96CN7	1
+GMP phosphodiesterase, delta subunit [IPR008015]	0.8544303797468348	1.3442535333207752	0.1788664159030331	1.0	0.4207843898467033	2	O43924	1
+Major facilitator superfamily domain [IPR020846]	0.676947581994029	1.3423101954483696	0.1794954390255168	1.0	0.4207843898467033	5	P11166,O43826	2
+SUN coiled coil domain 2 [IPR040994]	0.8395569620253158	1.2808743942031715	0.2002377880284047	1.0	0.4458581889144583	2	Q9UH99	1
+ATPase family AAA domain-containing protein 3, N-terminal [IPR021911]	0.8382911392405057	1.2754873404768354	0.2021368021456235	1.0	0.4489215951016696	2	Q9NVI7	1
+Tim10-like [IPR004217]	0.7041144172561129	1.2579074085827813	0.2084252440531895	1.0	0.4564585740577502	4	P62072	1
+Dynamin-type guanine nucleotide-binding (G) domain [IPR030381]	0.5959922620196425	1.2570698879035789	0.2087283298032869	1.0	0.4564585740577502	7	Q8IWA4,O60313	2
+Dynamin, N-terminal [IPR045063]	0.5959922620196425	1.2570698879035789	0.2087283298032869	1.0	0.4564585740577502	7	Q8IWA4,O60313	2
+Peptidase M48 [IPR001915]	0.8335443037974676	1.2552975549871102	0.209370762424538	1.0	0.4564585740577502	2	O75844	1
+Peptidase S54, rhomboid domain [IPR022764]	0.8332278481012649	1.2539522597683743	0.2098593582539401	1.0	0.4564585740577502	2	Q6NTF9	1
+Marvel domain [IPR008253]	0.8322784810126572	1.2499169176645903	0.2113298987348382	1.0	0.4582671940551588	2	O43760	1
+START domain [IPR002913]	0.821744994949619	1.2252674788911695	0.2204744573307746	1.0	0.4677879305559079	3	Q14849	1
+Bicarbonate transporter, C-terminal [IPR011531]	0.8262658227848093	1.224379793878377	0.220808988199467	1.0	0.4677879305559079	2	Q9Y6M7	1
+Band 3 cytoplasmic domain [IPR013769]	0.8262658227848093	1.224379793878377	0.220808988199467	1.0	0.4677879305559079	2	Q9Y6M7	1
+Yip1 domain [IPR006977]	0.8256329113924041	1.2216938075578367	0.2218234389095341	1.0	0.4683857530148986	2	Q9Y548	1
+CBS domain [IPR000644]	0.6153893895895319	1.2043287883442912	0.2284625239448874	1.0	0.4710808670836799	6	Q6P4Q7,P51790,Q8NE01	3
+Zinc finger, CHHC-type [IPR012996]	0.8160810383032606	1.2024984911728274	0.2291704503474929	1.0	0.4719077913555575	3	P55795,P52597	2
+Plasma membrane calcium transporting P-type ATPase, C-terminal [IPR022141]	0.8208860759493661	1.201562955864201	0.2295329011041973	1.0	0.4722763288906506	2	P20020	1
+Fatty acid hydroxylase [IPR006694]	0.8170886075949357	1.1854772818356265	0.2358287918037955	1.0	0.4821471883264255	2	Q15800	1
+Intermediate filament head, DNA-binding domain [IPR006821]	0.8106995884773646	1.1808835585761177	0.2376489836554114	1.0	0.4835640189162285	3	P07196,P08670	2
+Lysophosphatidylcholine acyltransferase LPCAT1-like [IPR045252]	0.8155063291139232	1.178780247252028	0.2384856917543505	1.0	0.4848203544499973	2	Q8NF37	1
+Rab-GTPase-TBC domain [IPR000195]	0.6405837073620884	1.1760409676716246	0.2395785055761545	1.0	0.4851265095746631	5	Q9NVG8,Q8TC07	2
+CNNM, transmembrane domain [IPR002550]	0.8107594936708851	1.158709199628586	0.24657473965329	1.0	0.4954593129333087	2	Q6P4Q7	1
+Ion transporter-like, CBS domain [IPR044751]	0.8107594936708851	1.158709199628586	0.24657473965329	1.0	0.4954593129333087	2	Q6P4Q7	1
+Ovarian carcinoma immunoreactive antigen domain [IPR009764]	0.8069620253164549	1.14267540359484	0.2531733856702107	1.0	0.5001291594129873	2	Q9NX40	1
+Fzo/mitofusin HR2 domain [IPR006884]	0.8041139240506319	1.1306644267833987	0.2581963593285756	1.0	0.5069393050432904	2	Q8IWA4	1
+Tudor domain [IPR002999]	0.5132341413555168	1.022618561465647	0.3064882300038252	1.0	0.5524514734102564	9	Q14739,Q16637	2
+Histidine kinase domain [IPR005467]	0.7753164556962014	1.0100620623638723	0.312465556759637	1.0	0.555063038715877	2	O14874	1
+Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase, N-terminal [IPR018955]	0.7753164556962014	1.0100620623638723	0.312465556759637	1.0	0.555063038715877	2	O14874	1
+Exportin-2, central domain [IPR013713]	0.7671727182045582	1.0071062677696494	0.3138837095282056	1.0	0.5568136928501732	3	O95373	1
+Guanylate kinase/L-type calcium channel beta subunit [IPR008145]	0.5077993849274299	0.9930513475668816	0.3206849319550753	1.0	0.5620874196641695	9	Q92796,Q14168,Q9NZW5,O14936	4
+Guanylate kinase-like domain [IPR008144]	0.5077993849274299	0.9930513475668816	0.3206849319550753	1.0	0.5620874196641695	9	Q92796,Q14168,Q9NZW5,O14936	4
+ABC transporter-like, ATP-binding domain [IPR003439]	0.4537751275552384	0.9877778201418138	0.3232614723852371	1.0	0.5627990773073867	14	P33527,P08183,Q03518,O75027	4
+Alpha-L-fucosidase, C-terminal [IPR031919]	0.7636075949367077	0.9615682332018012	0.3362665350648239	1.0	0.5720753874797468	2	P04066	1
+LEM-like domain [IPR013146]	0.7537974683544293	0.9212386935092512	0.3569258207982959	1.0	0.5904415570275152	2	P42167	1
+Tim44-like domain [IPR007379]	0.7449367088607581	0.8850783050630306	0.376114399550024	1.0	0.604243548876652	2	O43615	1
+Patatin-like phospholipase domain [IPR002641]	0.7319620253164543	0.8326442119834541	0.4050454164659995	1.0	0.6314023937731499	2	Q9NP80	1
+Immunoglobulin-like domain [IPR007110]	0.4530652974909593	0.8237620216537247	0.4100747908472528	1.0	0.6331320097757143	12	P10321,P35613,Q9BY67,Q08722	4
+AMP-dependent synthetase/ligase [IPR000873]	0.5078375459081305	0.8124741786048381	0.416519597195319	1.0	0.6399944209799434	7	Q96CM8	1
+L27 domain, C-terminal [IPR014775]	0.592421866011075	0.7757074743202111	0.4379217256965921	1.0	0.6582083917421873	4	Q9NZW5,Q14168	2
+Heterogeneous nuclear ribonucleoprotein Q acidic domain [IPR041337]	0.7129746835443023	0.757190990069708	0.4489354473314819	1.0	0.66872676008752	2	O60506	1
+Lamin tail domain [IPR001322]	0.6980056980056952	0.7387560987133269	0.4600551142614537	1.0	0.6738771066642201	3	Q03252,P20700	2
+L27 domain [IPR004172]	0.5404116962709282	0.7218760623457446	0.470370679700316	1.0	0.6798944824475686	5	Q9NZW5,Q14168	2
+Potassium channel tetramerisation-type BTB domain [IPR003131]	0.7037974683544288	0.7213482447812092	0.4706952808815092	1.0	0.6798944824475686	2	Q9NXV2	1
+NOPS [IPR012975]	0.6891421335865723	0.7055080901886324	0.4804940990643525	1.0	0.6882536510804915	3	Q8WXF1,Q15233	2
+FAD dependent oxidoreductase [IPR006076]	0.5754307965819139	0.7047543022578169	0.4809631515646386	1.0	0.688542353797208	4	Q9H9P8,Q96CU9	2
+Alpha-D-phosphohexomutase, alpha/beta/alpha domain I [IPR005844]	0.6833320412492215	0.6839009225069592	0.4940377314722819	1.0	0.6999621086423464	3	P36871	1
+Far upstream element-binding protein, C-terminal [IPR015096]	0.6914556962025302	0.6738777954718757	0.5003890100033295	1.0	0.7038984636990511	2	Q92945	1
+Alpha-D-phosphohexomutase, alpha/beta/alpha domain III [IPR005846]	0.6867088607594921	0.6558619385660962	0.5119129595724645	1.0	0.7100446320498426	2	P36871	1
+Alpha-D-phosphohexomutase, alpha/beta/alpha domain II [IPR005845]	0.6867088607594921	0.6558619385660962	0.5119129595724645	1.0	0.7100446320498426	2	P36871	1
+CARG-binding factor, N-terminal [IPR012956]	0.6838607594936692	0.64512082171301	0.5188488915356468	1.0	0.7145623578452407	2	Q99729	1
+FCP1 homology domain [IPR004274]	0.6803797468354413	0.6320646921409265	0.5273446056042241	1.0	0.7193175665691399	2	Q3ZCQ8	1
+Thioredoxin-like fold [IPR012336]	0.6794303797468338	0.6285179403690533	0.5296646978605606	1.0	0.7193175665691399	2	Q6DKJ4	1
+Ubiquitin system component CUE [IPR003892]	0.6635011079455488	0.6113981949898191	0.540935997322344	1.0	0.7242826868190966	3	Q9H4L7,Q9Y679	2
+Immunoglobulin subtype [IPR003599]	0.4319229803937974	0.6075946670407775	0.5434563387070201	1.0	0.7242826868190966	8	P35613	1
+Immunoglobulin subtype 2 [IPR003598]	0.4319229803937974	0.6075946670407775	0.5434563387070201	1.0	0.7242826868190966	8	P35613	1
+Histone-binding protein RBBP4, N-terminal [IPR022052]	0.6721518987341757	0.6015322577776328	0.5474855331862933	1.0	0.7282830813547901	2	Q9BQ67	1
+Glycosyltransferase 2-like [IPR001173]	0.5101049662034521	0.5898522019317882	0.5552897415536087	1.0	0.732720481241011	5	Q10472	1
+Zinc finger C2H2 AKAP95-type [IPR034736]	0.6571699905033204	0.5886990479871371	0.5560631766504429	1.0	0.732720481241011	3	Q9ULX6,O43823	2
+DALR anticodon binding [IPR008909]	0.6683544303797453	0.5876023298897584	0.5567992468171785	1.0	0.732720481241011	2	P54136	1
+Arginyl-tRNA synthetase, catalytic core domain [IPR035684]	0.6683544303797453	0.5876023298897584	0.5567992468171785	1.0	0.732720481241011	2	P54136	1
+PDZ-associated domain of NMDA receptors [IPR019583]	0.6620253164556945	0.5646244670022444	0.5723292197647198	1.0	0.7444039472836731	2	Q92796	1
+Disks large homologue 1, N-terminal PEST domain [IPR019590]	0.6620253164556945	0.5646244670022444	0.5723292197647198	1.0	0.7444039472836731	2	Q92796	1
+SCP2 sterol-binding domain [IPR003033]	0.6391263057929686	0.5253564776844324	0.5993354027758329	1.0	0.7612616457144716	3	P51659,Q6YN16	2
+Peptidase M3A/M3B catalytic domain [IPR001567]	0.6363259296613155	0.515718645270032	0.6060509302555339	1.0	0.7648751218219538	3	Q99797	1
+Heat shock protein Hsp90, N-terminal [IPR020575]	0.5278657378087352	0.5137194516468988	0.6074481503088427	1.0	0.7648751218219538	4	P14625,P07900,P08238	3
+Synaptotagmin-like mitochondrial-lipid-binding domain [IPR031468]	0.6346945235834084	0.5101293021079919	0.609960877825434	1.0	0.765576767288729	3	A0FGR8,Q9BSJ8	2
+Mu homology domain [IPR028565]	0.525785251779189	0.505691013963137	0.6130735775340559	1.0	0.7680559033135633	4	P48444,Q9BXS5	2
+Extended synaptotagmin, C-terminal C2 domain [IPR037752]	0.6348101265822766	0.4695584308969006	0.6386705296269439	1.0	0.7806803006174536	2	A0FGR8	1
+Extended synaptotagmin, C2B domain [IPR037749]	0.6348101265822766	0.4695584308969006	0.6386705296269439	1.0	0.7806803006174536	2	A0FGR8	1
+Synaptotagmin, SMP domain [IPR039010]	0.6348101265822766	0.4695584308969006	0.6386705296269439	1.0	0.7806803006174536	2	A0FGR8	1
+Extended synaptotagmin, C2A domain [IPR037733]	0.6348101265822766	0.4695584308969006	0.6386705296269439	1.0	0.7806803006174536	2	A0FGR8	1
+Fragile X-related 1 protein, C-terminal region 1 [IPR032172]	0.6329113924050613	0.4631721460742054	0.6432409798670218	1.0	0.7806803006174536	2	P51116	1
+Thioredoxin domain [IPR013766]	0.3187123562860706	0.4251626744573126	0.6707180918059343	1.0	0.799150188947065	26	Q6ZRP7,Q9H1E5,Q9Y320,Q9H3N1	4
+Copine, C-terminal [IPR010734]	0.5961025210415679	0.3839640579939866	0.7010050869761786	1.0	0.8135934397736172	3	Q86YQ8	1
+Copine, C2B domain [IPR037768]	0.5961025210415679	0.3839640579939866	0.7010050869761786	1.0	0.8135934397736172	3	Q86YQ8	1
+4Fe-4S ferredoxin-type, iron-sulphur binding domain [IPR017896]	0.4919559288214804	0.3802056612175633	0.7037927572005693	1.0	0.8149179293901329	4	P21912	1
+SUN domain [IPR012919]	0.5774324366534334	0.3276864057564654	0.7431487830149561	1.0	0.8336654769536006	3	Q9UH99	1
+Beta-Casp domain [IPR022712]	0.4765603753564431	0.3267614975840207	0.7438482826817849	1.0	0.8336654769536006	4	Q5TA45,Q9P2I0	2
+Zinc finger, CW-type [IPR011124]	0.5892405063291118	0.3266258443711372	0.7439508937693942	1.0	0.8336654769536006	2	Q9Y6X9	1
+Acyl-CoA-binding protein, ACBP [IPR000582]	0.5748455316266032	0.3201641299869288	0.7488439132706382	1.0	0.8367000581047088	3	Q5T8D3	1
+Metallo-beta-lactamase [IPR001279]	0.4415927374286422	0.3147903569446698	0.7529208338443432	1.0	0.8382431774720326	5	Q5TA45,Q9P2I0	2
+Polyadenylate-binding protein/Hyperplastic disc protein [IPR002004]	0.5713833491611215	0.3102063294279983	0.7564040576023454	1.0	0.8401871601406463	3	O95071,Q13310	2
+PABP, RNA recognition motif 2 [IPR045305]	0.5712025316455674	0.2766959619885578	0.7820135727328044	1.0	0.8594803314322111	2	Q13310	1
+Methionyl-tRNA synthetase, anticodon-binding domain [IPR041872]	0.557278481012656	0.2410334906494768	0.809529159807632	1.0	0.8840594218688352	2	P56192	1
+Methionyl/Leucyl tRNA synthetase [IPR015413]	0.557278481012656	0.2410334906494768	0.809529159807632	1.0	0.8840594218688352	2	P56192	1
+Methioninyl-tRNA synthetase core domain [IPR033911]	0.557278481012656	0.2410334906494768	0.809529159807632	1.0	0.8840594218688352	2	P56192	1
+DnaJ domain [IPR001623]	0.3235711254870541	0.239031319558066	0.8110812970538408	1.0	0.8853788204480858	16	Q96KC8,Q9NVH1,O14976	3
+Rpn11/EIF3F, C-terminal [IPR024969]	0.4442685243825194	0.2237889553362766	0.8229215243953338	1.0	0.8948880455401729	4	O00487,P51665,O00303	3
+Glutathione S-transferase, N-terminal [IPR004045]	0.3524419006360196	0.2205906179255973	0.8254112069323087	1.0	0.896075326759239	8	Q9H7Z7,Q8TB36	2
+EF hand associated, type-1 [IPR013566]	0.5484177215189849	0.2197035000363695	0.8261020786323521	1.0	0.896075326759239	2	Q8IXI2	1
+MIRO domain [IPR020860]	0.5484177215189849	0.2197035000363695	0.8261020786323521	1.0	0.896075326759239	2	Q8IXI2	1
+EF hand associated, type-2 [IPR013567]	0.5484177215189849	0.2197035000363695	0.8261020786323521	1.0	0.896075326759239	2	Q8IXI2	1
+NOT2/NOT3/NOT5, C-terminal [IPR007282]	0.5430379746835419	0.2072832370623685	0.8357886647425663	1.0	0.904295932344416	2	Q9NZN8	1
+PTBP1, RNA recognition motif 2-like [IPR021790]	0.4379354021532649	0.2052161618461547	0.8374032428305982	1.0	0.9056621626243528	4	Q9UKA9,Q8WVV9,P26599	3
+Proteasome activator PA28, N-terminal domain [IPR003185]	0.529338700262069	0.2000683396523085	0.8414271340436037	1.0	0.908106265420644	3	P61289	1
+Proteasome activator PA28, C-terminal domain [IPR003186]	0.529338700262069	0.2000683396523085	0.8414271340436037	1.0	0.908106265420644	3	P61289	1
+Zinc finger, RING-CH-type [IPR011016]	0.5373417721518963	0.1945747649450422	0.8457258601119078	1.0	0.9108361355347492	2	Q9NX47	1
+BAR domain [IPR004148]	0.5253725238654696	0.1907764002545402	0.8487007789519314	1.0	0.9132758382200132	3	Q9Y371	1
+Cobalamin (vitamin B12)-binding domain [IPR006158]	0.528797468354428	0.1763739452384209	0.8600001724660331	1.0	0.9223501849698206	2	Q99707	1
+Fumarylacetoacetase-like, C-terminal [IPR011234]	0.5224683544303772	0.1635638220830554	0.8700745268682224	1.0	0.9281364387357158	2	Q6P587	1
+Peptidase S9A, N-terminal domain [IPR023302]	0.5189873417721496	0.1567630910010519	0.8754315622506152	1.0	0.9322965830505104	2	Q4J6C6	1
+STAG [IPR013721]	0.5177215189873394	0.1543332376544046	0.8773469913990855	1.0	0.9331781635790272	2	Q8N3U4	1
+Stromalin conservative domain [IPR020839]	0.5177215189873394	0.1543332376544046	0.8773469913990855	1.0	0.9331781635790272	2	Q8N3U4	1
+ABC-transporter extension domain [IPR032781]	0.5158227848101242	0.150731611587325	0.8801874356830255	1.0	0.9342690554425186	2	Q9NUQ8	1
+Zinc finger, MYM-type [IPR010507]	0.5068059512503924	0.1499620047632662	0.8807945920160596	1.0	0.934528145032703	3	Q9UBW7,Q14202	2
+Dbl homology (DH) domain [IPR000219]	0.5063291139240482	0.1334997878318221	0.8937981320547888	1.0	0.9452122078303	2	Q92888	1
+ARHGEF1-like, PH domain [IPR041020]	0.5063291139240482	0.1334997878318221	0.8937981320547888	1.0	0.9452122078303	2	Q92888	1
+RAD23A/RAD23B, UBA1 domain [IPR041811]	0.5037974683544278	0.1291227259874957	0.8972605398002287	1.0	0.9468514358910436	2	P54725	1
+XPC-binding domain [IPR015360]	0.5037974683544278	0.1291227259874957	0.8972605398002287	1.0	0.9468514358910436	2	P54725	1
+Peptidase M16, middle/third domain [IPR032632]	0.5018987341772126	0.1258999925956697	0.8998110885376811	1.0	0.9476733804811748	2	P14735	1
+Cyclin-like [IPR013763]	0.3838042707215084	0.1250591445670789	0.9004767272156293	1.0	0.9477106760836754	5	O95067,Q00403	2
+Synaptic functional regulator FMRP, KH0 domain [IPR040472]	0.4928774928774893	0.1223133104976928	0.9026508908959324	1.0	0.947893159551015	3	P51114,P51116	2
+Agenet-like domain [IPR008395]	0.4928774928774893	0.1223133104976928	0.9026508908959324	1.0	0.947893159551015	3	P51114,P51116	2
+Fxr1, tudor domain [IPR041560]	0.4928774928774893	0.1223133104976928	0.9026508908959324	1.0	0.947893159551015	3	P51114,P51116	2
+Fragile X-related 1 protein, C-terminal core [IPR022034]	0.4928774928774893	0.1223133104976928	0.9026508908959324	1.0	0.947893159551015	3	P51114,P51116	2
+RBM3/CIRBP, RNA recognition motif [IPR034278]	0.4958860759493647	0.1160330277003657	0.9076263662572176	1.0	0.9511367587918278	2	P98179	1
+Zinc-finger CCCH domain [IPR041686]	0.4933544303797442	0.1120316648229588	0.9107982997080222	1.0	0.9526187823845792	2	O75152	1
+Glycogen synthase kinase 3, catalytic domain [IPR039192]	0.4908227848101239	0.1081205250610118	0.9139000869502194	1.0	0.9550868143767214	2	P49841	1
+Domain of unknown function DUF1899 [IPR015048]	0.4863924050632884	0.101491831077968	0.9191600419313752	1.0	0.9585489097751108	2	Q9ULV4	1
+Polypyrimidine tract-binding protein1/2/3, RNA recognition motif 2 [IPR034798]	0.4841772151898709	0.0982798105679776	0.9217101093937564	1.0	0.9589659747694136	2	Q9UKA9	1
+Putative RNA methylase domain [IPR000241]	0.481329113924048	0.0942495575164142	0.9249109187385658	1.0	0.9619073554881084	2	Q9BV44	1
+Septin-type guanine nucleotide-binding (G) domain [IPR030379]	0.3929702343255181	0.0908028110436712	0.9276492763913986	1.0	0.9643656047784572	4	Q9NVA2,Q16181,Q15019	3
+Ku70/Ku80 C-terminal arm [IPR005160]	0.4689873417721493	0.0780575021840715	0.9377823123468824	1.0	0.9725429782356468	2	P13010	1
+Ku70/Ku80, N-terminal alpha/beta [IPR005161]	0.4689873417721493	0.0780575021840715	0.9377823123468824	1.0	0.9725429782356468	2	P13010	1
+Ku70/Ku80 beta-barrel domain [IPR006164]	0.4689873417721493	0.0780575021840715	0.9377823123468824	1.0	0.9725429782356468	2	P13010	1
+Immunoglobulin V-set domain [IPR013106]	0.3862512634448835	0.0764981000788142	0.9390228254654256	1.0	0.9730453916054772	4	Q9BY67	1
+TIP49, P-loop domain [IPR010339]	0.4632911392405034	0.0712657371544239	0.9431862636597136	1.0	0.9757883611977908	2	Q9Y230	1
+RuvB-like, AAA-lid domain [IPR041048]	0.4632911392405034	0.0712657371544239	0.9431862636597136	1.0	0.9757883611977908	2	Q9Y230	1
+K Homology domain, type 1 [IPR004088]	0.2801655523718518	0.06952987543007	0.9445678530355366	1.0	0.9768250918897032	21	Q9Y6M1,Q15365,P51114,Q9Y2W6,Q07666,Q92945,P51116,Q9NQT5,P61978,Q15366,Q8TCS8,Q15637,O00425,Q92667,Q06787,Q96I24,Q96AE4,Q13868,Q96PU8,Q9NZI8	20
+EF-hand, Ca insensitive [IPR014837]	0.4599556821779003	0.0672512400084953	0.9463816937926016	1.0	0.9783078232217496	3	Q13813,O43707	2
+CDC48, N-terminal subdomain [IPR003338]	0.4582278481012634	0.065579325178405	0.9477127497909834	1.0	0.9788975192463848	2	P55072	1
+CDC48, domain 2 [IPR004201]	0.4582278481012634	0.065579325178405	0.9477127497909834	1.0	0.9788975192463848	2	P55072	1
+Ribosomal S6 kinase, N-terminal catalytic domain [IPR041906]	0.4512658227848073	0.0582852474861353	0.9535214183380298	1.0	0.9837130784777912	2	P51812	1
+ATP-dependent RNA helicase eIF4A, DEAD-box helicase domain [IPR044728]	0.4471518987341744	0.054253086995756	0.9567335256223346	1.0	0.9858415111897076	2	Q14240	1
+Ribosomal protein S10 domain [IPR027486]	0.442721518987339	0.0501352181187782	0.9600146350148338	1.0	0.987666333190122	2	P60866	1
+PDZ domain 6 [IPR041489]	0.438429882874319	0.0389358081417526	0.9689415674354164	1.0	0.9945764803810684	3	Q8NEN9,Q92614	2
+cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain [IPR003117]	0.4249999999999971	0.0358678327135786	0.9713877451309784	1.0	0.9961561975964696	2	P10644	1
+FAD/NAD(P)-binding domain [IPR023753]	0.3460883042447371	0.0309198012998955	0.9753334983185044	1.0	0.9994062200126714	5	O95831	1
+Laminin, N-terminal [IPR008211]	0.4123417721518956	0.027663288030282	0.9779307043978356	1.0	1.0	2	P11047	1
+Laminin-type EGF domain [IPR002049]	0.4123417721518956	0.027663288030282	0.9779307043978356	1.0	1.0	2	P11047	1
+Sec63 domain [IPR004179]	0.4283404011073876	0.0276579340877028	0.9779349745920636	1.0	1.0	3	Q9UGP8	1
+Hotdog acyl-CoA thioesterase (ACOT)-type domain [IPR033120]	0.389873417721516	0.0166020467282001	0.9867540917310724	1.0	1.0	2	Q9Y305	1
+tRNA/rRNA methyltransferase, SpoU type [IPR001537]	0.3620253164556932	0.0078622267025577	0.9937269153286096	1.0	1.0	2	Q9HC36	1
+Brdt, bromodomain, repeat II [IPR043509]	0.3544303797468322	0.0062204654218136	0.9950368186866608	1.0	1.0	2	P25440	1
+Brdt, bromodomain, repeat I [IPR043508]	0.3544303797468322	0.0062204654218136	0.9950368186866608	1.0	1.0	2	P25440	1
+NET domain [IPR027353]	0.3544303797468322	0.0062204654218136	0.9950368186866608	1.0	1.0	2	P25440	1
+Transcription factor CBF/NF-Y/archaeal histone domain [IPR003958]	0.4029756251978429	0.0045108648771331	0.9964008627644868	1.0	1.0	3	Q9NRG0,Q9NRF9	2
+Zinc finger, RanBP2-type [IPR001876]	0.2949778287497849	0.0042929554202836	0.996574727670934	1.0	1.0	8	Q92804,P35637	2
+Uncharacterised domain CHP00451 [IPR004521]	0.3098101265822751	0.0007945827578341	0.9993660147519564	1.0	1.0	2	Q9ULC4	1

interpro_family/advanced/idx2term.json

@@ -0,0 +1 @@
+{"0": "Mitochondrial carrier protein [IPR002067]", "1": "P-type ATPase [IPR001757]", "2": "Syntaxin [IPR045242]"}