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- interpro_active_site/advanced/idx2term.json +1 -0
- interpro_active_site/advanced/plot_0.png +3 -0
- interpro_active_site/basic/idx2term.json +1 -0
- interpro_active_site/basic/plot_0.png +3 -0
- interpro_active_site/consensus.joblib +3 -0
- interpro_active_site/df_merge.tsv +2 -0
- interpro_active_site/metrics.json +7 -0
- interpro_active_site/paths.json +1 -0
- interpro_active_site/result.tsv +5 -0
- interpro_active_site/selections.json +1 -0
- interpro_binding_site/advanced/idx2term.json +1 -0
- interpro_binding_site/basic/idx2term.json +1 -0
- interpro_binding_site/basic/plot_0.png +3 -0
- interpro_binding_site/consensus.joblib +3 -0
- interpro_binding_site/df_merge.tsv +2 -0
- interpro_binding_site/metrics.json +7 -0
- interpro_binding_site/paths.json +1 -0
- interpro_binding_site/result.tsv +5 -0
- interpro_binding_site/selections.json +1 -0
- interpro_conserved_site/advanced/idx2term.json +1 -0
- interpro_conserved_site/basic/idx2term.json +1 -0
- interpro_conserved_site/basic/plot_0.png +3 -0
- interpro_conserved_site/basic/plot_1.png +3 -0
- interpro_conserved_site/consensus.joblib +3 -0
- interpro_conserved_site/df_merge.tsv +5 -0
- interpro_conserved_site/metrics.json +7 -0
- interpro_conserved_site/paths.json +1 -0
- interpro_conserved_site/result.tsv +39 -0
- interpro_conserved_site/selections.json +1 -0
- interpro_domain/advanced/idx2term.json +1 -0
- interpro_domain/basic/idx2term.json +1 -0
- interpro_domain/basic/plot_0.png +3 -0
- interpro_domain/basic/plot_1.png +3 -0
- interpro_domain/basic/plot_10.png +3 -0
- interpro_domain/basic/plot_11.png +3 -0
- interpro_domain/basic/plot_12.png +3 -0
- interpro_domain/basic/plot_13.png +3 -0
- interpro_domain/basic/plot_14.png +3 -0
- interpro_domain/basic/plot_15.png +3 -0
- interpro_domain/basic/plot_16.png +3 -0
- interpro_domain/basic/plot_17.png +3 -0
- interpro_domain/basic/plot_18.png +3 -0
- interpro_domain/basic/plot_19.png +3 -0
- interpro_domain/basic/plot_2.png +3 -0
- interpro_domain/basic/plot_20.png +3 -0
- interpro_domain/basic/plot_21.png +3 -0
- interpro_domain/basic/plot_22.png +3 -0
- interpro_domain/basic/plot_23.png +3 -0
- interpro_domain/basic/plot_24.png +3 -0
- interpro_domain/basic/plot_25.png +3 -0
interpro_active_site/advanced/idx2term.json
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{"0": "Serine/threonine-protein kinase, active site [IPR008271]"}
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interpro_active_site/advanced/plot_0.png
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interpro_active_site/basic/idx2term.json
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{"0": "Serine/threonine-protein kinase, active site [IPR008271]"}
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interpro_active_site/basic/plot_0.png
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interpro_active_site/consensus.joblib
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oid sha256:cfbf38b13e24785bf1ff3c3448f6c7bd09d588e6dfc553cb9e2d2ca03c622ee4
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interpro_active_site/df_merge.tsv
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term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500
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Serine/threonine-protein kinase, active site [IPR008271] 17 45 2.1956320445114508 0.0281182907067074 14.96359223300971 48.092233009708735 -0.2514056606840174 0.5845564538757478 7.386430402173519 10.05983255009733 0.9463339478376924 0.3271131887386243 1.0 0.6711730681825154 0.6597869452777086 0.207447983839819 0.2467783832503134
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interpro_active_site/metrics.json
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{
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"type_of_task": "ranksum",
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"signature_size": 3018,
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"annotations_size": 57,
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"title": "Average number of proteins per term",
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"value": 2.5789473684210527
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}
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interpro_active_site/paths.json
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{"results_path": "results/proteins/hek293t_core/interpro_active_site/fragment/C254/C254_val_log2fc"}
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interpro_active_site/result.tsv
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Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size
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Ubiquitin-activating enzyme E1, Cys active site [IPR033127] 0.6583747927031653 2.298778015815243 0.0215175477897369 0.7105834452814277 0.0292023862860715 3 Q8TBC4,Q9UBT2 2
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Serine/threonine-protein kinase, active site [IPR008271] 0.4723069917741835 2.1956320445114508 0.0281182907067074 0.8032275453897042 0.0352267484966215 45 Q96KB5,O96017,Q99570,Q9Y3S1,O14976,P11802,P54646,Q13976,P33981,Q86UE8,O15111,O14757,O95819,P48729,Q96SB4,Q8TD19,Q9NYV4 17
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Ubiquitin-conjugating enzyme, active site [IPR023313] 0.5785320550165717 1.1667420451187809 0.243314557791288 0.9999998746349188 0.2476594606089896 6 P61088,P68036,P61081,Q16763 4
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Protein-tyrosine phosphatase, active site [IPR016130] 0.5547673378084446 1.1002636563678398 0.2712172623233577 0.99999998527381 0.2712172623233577 7 P10586,Q9Y217 2
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interpro_active_site/selections.json
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{"all_annotations": ["ATP synthase, F0 complex, subunit A, active site [IPR023011]", "ATP-citrate lyase/succinyl-CoA ligase, active site [IPR017440]", "ATP:guanido phosphotransferase active site [IPR022415]", "ATPase, alpha/beta subunit, nucleotide-binding domain, active site [IPR020003]", "Adenylosuccinate synthase, active site [IPR033128]", "Beta-ketoacyl synthase, active site [IPR018201]", "Citrate synthase active site [IPR019810]", "ClpP, Ser active site [IPR018215]", "ClpP, histidine active site [IPR033135]", "Coenzyme A transferase active site [IPR004164]", "Cysteine peptidase, asparagine active site [IPR025661]", "Cysteine peptidase, cysteine active site [IPR000169]", "Cysteine peptidase, histidine active site [IPR025660]", "DNA methylase, C-5 cytosine-specific, active site [IPR018117]", "DNA topoisomerase I, active site [IPR018521]", "Ferrochelatase, active site [IPR019772]", "Glucose-6-phosphate dehydrogenase, active site [IPR019796]", "Glutaredoxin active site [IPR011767]", "Glyceraldehyde 3-phosphate dehydrogenase, active site [IPR020830]", "Glycoside hydrolase, family 2, active site [IPR023232]", "Glycosyl hydrolases family 31, active site [IPR030458]", "Histidine acid phosphatase active site [IPR033379]", "Hydroxymethylglutaryl-CoA lyase, active site [IPR000138]", "Hydroxymethylglutaryl-coenzyme A synthase, active site [IPR000590]", "L-lactate dehydrogenase, active site [IPR018177]", "Leu/Phe/Val dehydrogenases active site [IPR033524]", "Lipase, GDXG, putative serine active site [IPR033140]", "Malate dehydrogenase, active site [IPR001252]", "Nucleoside diphosphate kinase, active site [IPR023005]", "Orotidine 5'-phosphate decarboxylase, active site [IPR018089]", "Peptidase S16, active site [IPR008268]", "Peptidase S26A, signal peptidase I, serine active site [IPR019756]", "Peptidase S8, subtilisin, His-active site [IPR022398]", "Peptidase S8, subtilisin, Ser-active site [IPR023828]", "Peptidase S9, serine active site [IPR002471]", "Peptidase family C14A, His active site [IPR016129]", "Peptidase family C14A, cysteine active site [IPR033139]", "Phosphoglycerate/bisphosphoglycerate mutase, active site [IPR001345]", "Phosphoribosylglycinamide formyltransferase, active site [IPR001555]", "Protein-tyrosine phosphatase, active site [IPR016130]", "Pyridine nucleotide-disulphide oxidoreductase, class I, active site [IPR012999]", "Pyruvate kinase, active site [IPR018209]", "Ribonuclease T2, His active site 1 [IPR018188]", "Ribonuclease T2, His active site 2 [IPR033130]", "Ribonucleotide reductase small subunit, acitve site [IPR030475]", "Serine carboxypeptidase, serine active site [IPR018202]", "Serine carboxypeptidases, histidine active site [IPR033124]", "Serine/threonine-protein kinase, active site [IPR008271]", "Thermonuclease active site [IPR002071]", "Thiolase, active site [IPR020610]", "Thiolase, acyl-enzyme intermediate active site [IPR020615]", "Thymidylate synthase, active site [IPR020940]", "Transaldolase, active site [IPR018225]", "Triosephosphate isomerase, active site [IPR020861]", "Tyrosine-protein kinase, active site [IPR008266]", "Ubiquitin-activating enzyme E1, Cys active site [IPR033127]", "Ubiquitin-conjugating enzyme, active site [IPR023313]"], "available_proteins": ["ACAA1", "ACAA2", "ACAT1", "ACAT2", "ACLY", "ACP2", "ACP6", "ADSS", "APEH", "ATP5A1", "ATP5B", "ATP6", "ATP6V1A", "ATP6V1B2", "BLMH", "CAMK2G", "CAPN1", "CAPN2", "CASP7", "CDC34", "CDK1", "CDK12", "CDK13", "CDK2", "CDK4", "CDK5", "CDK6", "CDK9", "CHEK1", "CHEK2", "CHUK", "CKB", "CKMT1A*", "CLK2", "CLK3", "CLPP", "CPVL", "CS", "CSK", "CSNK1A1", "CSNK2A2", "CTSA", "CTSC", "DLD", "DNMT1", "DUSP11", "DUSP3", "EIF2AK2", "EPHA7", "FASN", "FECH", "G6PD", "GAA", "GAK", "GANAB", "GAPDH", "GART", "GLRX", "GLUD1", "GSR", "GUSB", "HADHB", "HMGCL", "HMGCS1", "IGF1R", "IKBKB", "LDHA", "LDHB", "LONP1", "LONP2", "LYN", "MAP2K1", "MAP2K4", "MAP4K4", "MAPK1", "MAPK3", "MARK2", "MDH1", "MDH2", "MTMR6", "NCEH1", "NEK9", "NME1", "NME2", "NME6", "OXCT1", "PAK2", "PBK", "PGAM1", "PIK3R4", "PKM", "PKMYT1", "PKN2", "PLK1", "PREP", "PRKAA2", "PRKACA", "PRKG1", "PRPF4B", "PTK7", "PTPMT1", "PTPN1", "PTPN11", "PTPRF", "RNASET2", "ROCK1", "RPS6KA1", "RPS6KA3", "RRM2", "SCP2", "SCPEP1", "SEC11A", "SLK", "SND1", "SRC", "SRPK1", "SUCLG1", "TALDO1", "TLK2", "TOP1", "TPI1", "TPP2", "TTK", "TXNRD1", "TYMS", "UBA1", "UBA2", "UBA3", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2S", "UMPS", "VRK1", "WNK2"], "leading_proteins": ["CDK12", "CDK4", "CHEK1", "CHEK2", "CHUK", "CSNK1A1", "GAK", "MAP4K4", "MTMR6", "NEK9", "PBK", "PIK3R4", "PRKAA2", "PRKG1", "PTPRF", "SRPK1", "TLK2", "TTK", "UBA2", "UBA3", "UBE2L3", "UBE2M", "UBE2N", "UBE2S", "WNK2"]}
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interpro_binding_site/advanced/idx2term.json
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{}
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interpro_binding_site/basic/idx2term.json
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{"0": "Protein kinase, ATP binding site [IPR017441]"}
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interpro_binding_site/basic/plot_0.png
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interpro_binding_site/consensus.joblib
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version https://git-lfs.github.com/spec/v1
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oid sha256:39e16e747a9e61ecdd7d6f590b20184eb72f0bf492a492794a766865acf23f27
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size 75474
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interpro_binding_site/df_merge.tsv
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term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500
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Beta tubulin, autoregulation binding site [IPR013838] 2 7 2.639302910582568 0.0083076713568714 3.5533980582524274 5.54126213592233 0.5823511994709325 0.3808337519133083 1.5578062452886454 0.9632803779920796 1.1906256051626651 0.3058955364405814 1.0 0.04159641685533 6.936272072908627e-05 0.0010713621736615 0.0077568745967145
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interpro_binding_site/metrics.json
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{
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"type_of_task": "ranksum",
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"signature_size": 3018,
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"annotations_size": 30,
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"title": "Average number of proteins per term",
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"value": 4.733333333333333
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}
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interpro_binding_site/paths.json
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{"results_path": "results/proteins/hek293t_core/interpro_binding_site/fragment/C254/C254_val_log2fc"}
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Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size
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Beta tubulin, autoregulation binding site [IPR013838] 0.8977810204617597 2.639302910582568 0.0083076713568714 0.2214103768427439 0.0138461189281191 7 Q9BVA1,Q13509 2
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IQ motif, EF-hand binding site [IPR000048] 0.4705679402918188 0.923475127130966 0.3557596565472019 0.9999981317390844 0.4235963790225194 11 Q15386,O94832,Q9Y4I1,P35580 4
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Protein kinase, ATP binding site [IPR017441] 0.3168353384487318 0.8120359810317328 0.4167709856512838 0.9999999055561613 0.4465403417692326 45 Q9NYV4,Q02750,P11802,P54646,Q14004,Q13177,Q13976,P41240,P33981,Q86UE8,O15111,O14757,O95819,P48729,Q96SB4,P27361,Q13043,P53350 18
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PPM-type phosphatase, divalent cation binding [IPR000222] 0.3382874826669563 0.5189789045376523 0.6037754521929635 0.9999999999991326 0.6245952953720312 3 O15355 1
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interpro_binding_site/selections.json
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{"all_annotations": ["2-oxo acid dehydrogenase, lipoyl-binding site [IPR003016]", "2Fe-2S ferredoxin, iron-sulphur binding site [IPR006058]", "6-phosphogluconate-binding site [IPR006184]", "AP endonuclease 1, binding site [IPR020847]", "Aconitase family, 4Fe-4S cluster binding site [IPR018136]", "Adenylosuccinate synthase, GTP-binding site [IPR018220]", "Aminotransferase class-V, pyridoxal-phosphate binding site [IPR020578]", "Aminotransferase, class-II, pyridoxal-phosphate binding site [IPR001917]", "Aminotransferases, class-I, pyridoxal-phosphate-binding site [IPR004838]", "Beta tubulin, autoregulation binding site [IPR013838]", "Biotin-binding site [IPR001882]", "Coenzyme A transferase binding site [IPR004163]", "Copper centre Cu(A) [IPR001505]", "Cytochrome b5, heme-binding site [IPR018506]", "Cytochrome c oxidase, subunit Vb, zinc binding site [IPR020893]", "EF-Hand 1, calcium-binding site [IPR018247]", "Fumarate reductase/succinate dehydrogenase, FAD-binding site [IPR003952]", "Hexokinase, binding site [IPR019807]", "IQ motif, EF-hand binding site [IPR000048]", "Inositol monophosphatase, metal-binding site [IPR020583]", "Manganese/iron superoxide dismutase, binding site [IPR019833]", "PPM-type phosphatase, divalent cation binding [IPR000222]", "Peptidase M16, zinc-binding site [IPR001431]", "Peptidase M24A, methionine aminopeptidase, subfamily 2, binding site [IPR018349]", "Porphobilinogen deaminase, dipyrromethane cofactor binding site [IPR022419]", "Protein kinase, ATP binding site [IPR017441]", "RNA polymerases, subunit N, zinc binding site [IPR020789]", "Serine hydroxymethyltransferase, pyridoxal phosphate binding site [IPR019798]", "Sigma-54 interaction domain, ATP-binding site 1 [IPR025662]", "Transketolase binding site [IPR020826]"], "available_proteins": ["ACACA", "ACO1", "ACO2", "ACTN1", "ACTN4", "ADSS", "APEX1", "BPNT1", "CALU", "CAMK2G", "CAPN1", "CAPN2", "CAPNS1", "CDK1", "CDK12", "CDK13", "CDK2", "CDK4", "CDK5", "CDK6", "CDK9", "CETN2", "CHEK1", "CHUK", "CLK2", "CLK3", "COX2", "COX5B", "CSK", "CSNK1A1", "CSNK2A2", "CYB5B", "DBT", "DLAT", "DLST", "EHD1", "EIF2AK2", "EPHA7", "FKBP10", "FKBP14", "FKBP7", "GCAT", "GOT1", "GOT2", "GPD2", "HK1", "HK2", "HMBS", "IDE", "IGF1R", "ILKAP", "IQGAP1", "IQGAP2", "LETM1", "LYN", "MACF1", "MAP2K1", "MAP2K4", "MAP4K4", "MAPK1", "MAPK3", "MARK2", "MCCC1", "METAP2", "MICU1", "MYH10", "MYH14", "MYH9", "MYO1B", "MYO1C", "MYO1D", "MYO1E", "MYO5A", "NFS1", "NRDC", "NUCB1", "NUCB2", "OXCT1", "OXSR1", "PA2G4", "PAK2", "PC", "PCCA", "PDCD6", "PDHX", "PEF1", "PGD", "PKMYT1", "PKN2", "PLCG1", "PLK1", "PLS1", "PLS3", "PMPCA", "PMPCB", "POLR2L", "PPM1F", "PPM1G", "PRKAA2", "PRKACA", "PRKCSH", "PRKG1", "PSAT1", "RAB18", "RCN1", "RCN2", "REPS1", "RHOT1", "RHOT2", "ROCK1", "RPS6KA1", "RPS6KA3", "S100A11", "SDF4", "SDHA", "SDHB", "SHMT1", "SHMT2", "SLC25A12", "SLC25A24", "SLK", "SOD2", "SPTAN1", "SPTLC2", "SRC", "SRI", "SRPK1", "STK26", "STK4", "TKT", "TLK2", "TTK", "TUBB", "TUBB2A", "TUBB2B", "TUBB3", "TUBB4A", "TUBB4B", "TUBB6", "UBE3C", "UQCRC2", "VRK1"], "leading_proteins": ["CDK12", "CDK13", "CDK4", "CHEK1", "CHUK", "CSK", "CSNK1A1", "MAP2K1", "MAP4K4", "MAPK3", "MYH10", "MYO1D", "MYO5A", "PAK2", "PLK1", "PPM1G", "PRKAA2", "PRKG1", "SRPK1", "STK4", "TLK2", "TTK", "TUBB2B", "TUBB3", "UBE3C"]}
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{"0": "Ubiquitin specific protease, conserved site [IPR018200]", "1": "Actinin-type actin-binding domain, conserved site [IPR001589]"}
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interpro_conserved_site/basic/plot_0.png
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interpro_conserved_site/basic/plot_1.png
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oid sha256:d987a933c1971c5d27a4e889e08aeeb50ecad2559f017b0936e5acb3f5eba929
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interpro_conserved_site/df_merge.tsv
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term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500
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Tubulin, conserved site [IPR017975] 2 7 2.639302910582568 0.0083076713568714 3.6140776699029127 5.883495145631068 0.537603280896448 0.3771225437200781 1.6631634011190108 1.117390952728082 1.2199662970774952 0.3090115161057067 1.0 0.0814971443263516 0.0006327439593496 0.0088528623379573 0.0544656750173612
|
| 3 |
+
Phosphatidylinositol 3/4-kinase, conserved site [IPR018936] 0 5 2.369820725300739 0.0177967122048758 2.3592233009708736 5.065533980582524 -0.0414779785270424 0.5135274314368297 1.4687975990686668 1.3840549880732227 1.041360968799742 0.3265718594638703 1.0 0.0595353304203936 0.1180585699575878 0.2740704871267072 0.4779737602264646
|
| 4 |
+
Isocitrate/isopropylmalate dehydrogenase, conserved site [IPR019818] 1 5 2.338453661629163 0.019363726807708 1.8349514563106797 4.495145631067961 -0.0268416016144192 0.3268992301433215 1.18113888908689 0.4999764345469411 1.4254920509394828 0.309635855483207 1.0 0.0002150789234385 0.0008973897437505 0.0056136137273067 0.0214944247869924
|
| 5 |
+
Proteasome beta-type subunit, conserved site [IPR016050] 3 7 2.179463307894787 0.0292972675744798 3.7135922330097086 7.970873786407767 1.4913184573846054 0.1902243906475925 1.515457478026574 0.1681602725795027 1.0170822776023185 0.2455850375425174 1.0 0.0461123069087121 1.612359251599596e-06 6.393058955734768e-05 0.0009257875785001
|
interpro_conserved_site/metrics.json
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{
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| 2 |
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"type_of_task": "ranksum",
|
| 3 |
+
"signature_size": 3018,
|
| 4 |
+
"annotations_size": 270,
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| 5 |
+
"title": "Average number of proteins per term",
|
| 6 |
+
"value": 2.6555555555555554
|
| 7 |
+
}
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interpro_conserved_site/paths.json
ADDED
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{"results_path": "results/proteins/hek293t_core/interpro_conserved_site/fragment/C254/C254_val_log2fc"}
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interpro_conserved_site/result.tsv
ADDED
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Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size
|
| 2 |
+
DNA-directed DNA polymerase, family B, conserved site [IPR017964] 0.8554376657824907 3.6488327183601337 0.000263434563656 0.06866543236824 0.0008781152121869 2 P09884 1
|
| 3 |
+
Mrp, conserved site [IPR000808] 0.8411803713527808 3.5792020331360255 0.0003446449576176 0.0888704427983885 0.0010574333926905 2 Q8TB37 1
|
| 4 |
+
Sterol reductase, conserved site [IPR018083] 0.8176392572944267 3.4628588927544657 0.0005344686066748 0.1344110192878051 0.0015040353406549 2 Q9UBM7 1
|
| 5 |
+
Hexapeptide transferase, conserved site [IPR018357] 0.7652519893899423 3.197560094588106 0.0013859552990456 0.3123446341803525 0.0033712426193001 2 Q9Y5P6 1
|
| 6 |
+
Profilin conserved site [IPR027310] 0.7257957559681638 2.9916097697219652 0.0027751074868074 0.5277848702265157 0.0059238097039861 2 P07737 1
|
| 7 |
+
Purine phosphorylase, family 2, conserved site [IPR018099] 0.7224801061007944 2.9740528645297246 0.0029389443750862 0.5482757353019783 0.0061993357911975 2 P00491 1
|
| 8 |
+
Clathrin adaptor, mu subunit, conserved site [IPR018240] 0.7868911049872648 2.950687013023677 0.0031706803282838 0.575754825078587 0.0065852591433587 3 Q9Y2T2 1
|
| 9 |
+
4Fe-4S ferredoxin, iron-sulphur binding, conserved site [IPR017900] 0.7072281167108747 2.8927797305529857 0.0038184898576818 0.6440502478134095 0.0075254909603948 2 P21912 1
|
| 10 |
+
Phosphofructokinase, conserved site [IPR015912] 0.7442786069651803 2.7403414045871175 0.0061375394510712 0.8102868194677835 0.0111217157838203 3 Q01813,P17858 2
|
| 11 |
+
HMG box A DNA-binding domain, conserved site [IPR017967] 0.7372155614679883 2.704930648957883 0.0068318650856289 0.8429095399544769 0.0116501104829203 3 P09429 1
|
| 12 |
+
Tubulin, conserved site [IPR017975] 0.8977810204617597 2.639302910582568 0.0083076713568714 0.8948576931560807 0.0137611734132227 7 Q9BVA1,Q13509 2
|
| 13 |
+
Ubiquitin-activating enzyme E1, conserved site [IPR018074] 0.6581564986737373 2.625449566414876 0.0086534627450201 0.9043062956497718 0.0140481517336573 2 Q9UBT2 1
|
| 14 |
+
S-adenosyl-L-homocysteine hydrolase, conserved site [IPR020082] 0.6312997347480112 2.4752560871915725 0.0133140670484881 0.973189008590894 0.0200826709669932 2 O43865 1
|
| 15 |
+
Isocitrate/isopropylmalate dehydrogenase, conserved site [IPR019818] 0.783286535129845 2.338453661629163 0.019363726807708 0.9949049617321232 0.0281086356886084 5 P48735 1
|
| 16 |
+
Ras GTPase-activating protein, conserved site [IPR023152] 0.6064323607426989 2.333680934620451 0.0196124351235673 0.995242219523628 0.0283174196971293 2 P46940 1
|
| 17 |
+
D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site [IPR029753] 0.7147081391313999 2.2866818717393125 0.0222143985770628 0.9976784279053248 0.0310102424727785 4 Q13363 1
|
| 18 |
+
Proteasome beta-type subunit, conserved site [IPR016050] 0.7900448107013002 2.179463307894787 0.0292972675744798 0.9996739470963916 0.0391597140847007 7 P28074,P28070,P20618 3
|
| 19 |
+
F-actin capping protein, alpha subunit, conserved site [IPR017865] 0.5507294429708124 2.007766989489038 0.0446680582244822 0.9999956181181884 0.0566214822563859 2 P47755 1
|
| 20 |
+
Phosphorylase pyridoxal-phosphate attachment site [IPR035090] 0.5288461538461426 1.8764804676932 0.0605893343090024 0.9999999531206692 0.0753876509835514 2 P11216 1
|
| 21 |
+
Fumarate lyase, conserved site [IPR020557] 0.5086206896551599 1.7536075971965948 0.0794977683529012 0.9999999998064878 0.0975654429785606 2 P07954 1
|
| 22 |
+
Dynamin, GTPase region, conserved site [IPR019762] 0.5056366047745254 1.7353605291020464 0.0826769667353972 0.9999999999239638 0.1010080589074989 2 O00429 1
|
| 23 |
+
DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site [IPR002464] 0.5840862440640947 1.637815663461794 0.1014601530894452 0.9999999999997148 0.122295720241742 13 Q9H2U1,Q86WJ1,Q8IX18 3
|
| 24 |
+
Alpha-D-phosphohexomutase, conserved site [IPR016066] 0.5328594643546611 1.611236174171029 0.1071282561340063 0.9999999999999484 0.1285539073608076 3 O95394 1
|
| 25 |
+
Ubiquitin specific protease, conserved site [IPR018200] 0.6012198621965988 1.6084362132142709 0.1077396758364364 0.999999999999957 0.1287155419284859 11 Q96K76,Q14694,Q9Y4E8,P45974,O94966,Q93009,Q93008 7
|
| 26 |
+
GHMP kinase, ATP-binding, conserved site [IPR006203] 0.4731432360742603 1.5348922288616684 0.1248103027168039 0.9999999999999998 0.1471562521115155 2 Q03426 1
|
| 27 |
+
Guanylate kinase, conserved site [IPR020590] 0.6211458778326328 1.362453235984978 0.1730548927994963 1.0 0.2031513958950609 6 Q14168 1
|
| 28 |
+
14-3-3 protein, conserved site [IPR023409] 0.5475484572766087 1.2173443878865335 0.2234732124723706 1.0 0.2600765834807761 5 P31946 1
|
| 29 |
+
Acyl-CoA-binding protein, ACBP, conserved site [IPR022408] 0.4124668435013188 1.1545863991432035 0.2482598389344161 1.0 0.2864536603089417 2 Q9H3P7 1
|
| 30 |
+
Cullin, conserved site [IPR016157] 0.5293520849605708 1.1277656971318342 0.2594188838559275 1.0 0.2967927908521204 5 Q93034,Q13616,Q13617 3
|
| 31 |
+
Zinc finger, RING-type, conserved site [IPR017907] 0.4903412507782915 1.1225617117261923 0.2616236843431361 1.0 0.2980522986187626 13 Q9UPN9,Q14527,Q14258,P19474 4
|
| 32 |
+
Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site [IPR020892] 0.4343027041738994 0.7762971069654278 0.4375735808664356 1.0 0.4746287785393827 12 Q13356 1
|
| 33 |
+
Cadherin conserved site [IPR020894] 0.3854971408975359 0.5940507019111094 0.5524782019828869 1.0 0.5849769197465862 4 O60245 1
|
| 34 |
+
Actinin-type actin-binding domain, conserved site [IPR001589] 0.3862667868435667 0.5698402986854209 0.56878602021963 1.0 0.599891505700391 13 Q14315,P21333,O15020,P46939,O75369 5
|
| 35 |
+
Bromodomain, conserved site [IPR018359] 0.3778098885043474 0.4974312586608623 0.618884967015815 1.0 0.6501904322734243 12 P25440,Q09472 2
|
| 36 |
+
Adenylate kinase, conserved site [IPR033690] 0.3925092127770212 0.4848451503334599 0.6277861925093327 1.0 0.6569855503004643 5 P30085 1
|
| 37 |
+
ATPase, AAA-type, conserved site [IPR003960] 0.3157563055136798 0.3573156437020142 0.7208555199935991 1.0 0.7400417885865846 19 Q8NB90,Q9ULI0 2
|
| 38 |
+
Tr-type G domain, conserved site [IPR031157] 0.3779407662213926 0.317599733284852 0.750788576480395 1.0 0.7678519532185858 6 P15170,Q05639 2
|
| 39 |
+
Kinesin motor domain, conserved site [IPR019821] 0.287286303884417 0.1653202724345631 0.8686919032655926 1.0 0.8719212411959479 13 P33176,Q15058,O95239 3
|
interpro_conserved_site/selections.json
ADDED
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{"all_annotations": ["14-3-3 protein, conserved site [IPR023409]", "3-hydroxyacyl-CoA dehydrogenase, conserved site [IPR006180]", "3-hydroxyisobutyrate dehydrogenase-related, conserved site [IPR002204]", "4Fe-4S ferredoxin, iron-sulphur binding, conserved site [IPR017900]", "ABC transporter-like, conserved site [IPR017871]", "AMP-binding, conserved site [IPR020845]", "AP endonuclease 1, conserved site [IPR020848]", "AT hook, DNA-binding motif [IPR017956]", "ATP synthase, F1 complex, gamma subunit conserved site [IPR023632]", "ATP-citrate lyase/succinyl-CoA ligase, conserved site [IPR033847]", "ATP-dependent RNA helicase DEAD-box, conserved site [IPR000629]", "ATPase, AAA-type, conserved site [IPR003960]", "ATPase, OSCP/delta subunit, conserved site [IPR020781]", "Acin1, RNSP1-SAP18 binding (RSB) motif [IPR032552]", "Actin, conserved site [IPR004001]", "Actin/actin-like conserved site [IPR020902]", "Actinin-type actin-binding domain, conserved site [IPR001589]", "Acyl-CoA dehydrogenase, conserved site [IPR006089]", "Acyl-CoA-binding protein, ACBP, conserved site [IPR022408]", "Adenylate kinase, conserved site [IPR033690]", "Alanine dehydrogenase/NAD(P) transhydrogenase, conserved site-1 [IPR008142]", "Alanine dehydrogenase/pyridine nucleotide transhydrogenase, conserved site-2 [IPR008143]", "Alcohol dehydrogenase, zinc-type, conserved site [IPR002328]", "Aldehyde dehydrogenase, cysteine active site [IPR016160]", "Aldehyde dehydrogenase, glutamic acid active site [IPR029510]", "Aldo/keto reductase, conserved site [IPR018170]", "Alpha-D-phosphohexomutase, conserved site [IPR016066]", "Aminoacyl-tRNA synthetase, class I, conserved site [IPR001412]", "Aminotransferase, class IV, conserved site [IPR018300]", "Amyloidogenic glycoprotein, copper-binding domain conserved site [IPR019744]", "Amyloidogenic glycoprotein, intracellular domain, conserved site [IPR019745]", "Anion exchange, conserved site [IPR018241]", "Annexin repeat, conserved site [IPR018252]", "Apoptosis regulator, Bcl-2, BH1 motif, conserved site [IPR020717]", "Apoptosis regulator, Bcl-2, BH2 motif, conserved site [IPR020726]", "Apoptosis regulator, Bcl-2, BH3 motif, conserved site [IPR020728]", "ArgE/DapE/ACY1/CPG2/YscS, conserved site [IPR001261]", "BUD31/G10-related, conserved site [IPR018230]", "Bacterial Fmu (Sun)/eukaryotic nucleolar NOL1/Nop2p, conserved site [IPR018314]", "Bromodomain, conserved site [IPR018359]", "CAMSAP, spectrin and Ca2+/calmodulin-binding region [IPR031372]", "CAP, conserved site, C-terminal [IPR028417]", "CAP, conserved site, N-terminal [IPR018106]", "CBX family C-terminal motif [IPR033773]", "Cadherin conserved site [IPR020894]", "Calreticulin/calnexin, conserved site [IPR018124]", "Carbohydrate/purine kinase, PfkB, conserved site [IPR002173]", "Chaperonin Cpn60, conserved site [IPR018370]", "Chaperonin GroES, conserved site [IPR018369]", "Chaperonin TCP-1, conserved site [IPR002194]", "Chromo domain, conserved site [IPR023779]", "Clathrin adaptor complex, small chain [IPR000804]", "Clathrin adaptor, mu subunit, conserved site [IPR018240]", "Coproporphyrinogen III oxidase, conserved site [IPR018375]", "Cullin, conserved site [IPR016157]", "Cyclic nucleotide-binding, conserved site [IPR018488]", "Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site [IPR020892]", "Cytochrome P450, conserved site [IPR017972]", "D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site 1 [IPR029752]", "D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site [IPR029753]", "DNA ligase, ATP-dependent, conserved site [IPR016059]", "DNA methylase, C-5 cytosine-specific, conserved site [IPR031303]", "DNA methylase, N-6 adenine-specific, conserved site [IPR002052]", "DNA topoisomerase, type IIA, conserved site [IPR018522]", "DNA-directed DNA polymerase, family B, conserved site [IPR017964]", "DNA-directed RNA polymerase, 30-40kDa subunit, conserved site [IPR001514]", "DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site [IPR002464]", "Dihydrofolate reductase conserved site [IPR017925]", "Dihydroorotase, conserved site [IPR002195]", "Dihydroorotate dehydrogenase, conserved site [IPR001295]", "DnaJ domain, conserved site [IPR018253]", "Dpy-30 motif [IPR007858]", "Dynamin, GTPase region, conserved site [IPR019762]", "Dynein light chain, type 1/2, conserved site [IPR019763]", "EGF-like calcium-binding, conserved site [IPR018097]", "EGF-like, conserved site [IPR013032]", "Electron transfer flavoprotein subunit alpha, conserved site [IPR018206]", "Electron transfer flavoprotein, beta-subunit, conserved site [IPR000049]", "Endonuclease III-like, conserved site-2 [IPR004036]", "Endonuclease III-like, iron-sulphur cluster loop motif [IPR003651]", "Enolase, conserved site [IPR020809]", "Enoyl-CoA hydratase/isomerase, conserved site [IPR018376]", "Eukaryotic translation initiation factor 4E (eIF-4E), conserved site [IPR019770]", "F-actin capping protein, alpha subunit, conserved site [IPR017865]", "F-actin capping protein, beta subunit, conserved site [IPR019771]", "FERM conserved site [IPR019747]", "Fibrillarin, conserved site [IPR020813]", "Fork head domain conserved site 2 [IPR030456]", "Fork head domain conserved site1 [IPR018122]", "Formate-tetrahydrofolate ligase, FTHFS, conserved site [IPR020628]", "Fructose-bisphosphate aldolase class-I active site [IPR029768]", "Fumarate lyase, conserved site [IPR020557]", "GHMP kinase, ATP-binding, conserved site [IPR006203]", "GTP1/OBG, conserved site [IPR006074]", "Galactokinase, conserved site [IPR019741]", "Gamma-glutamyl phosphate reductase GPR, conserved site [IPR020593]", "Glucosamine-6-phosphate isomerase, conserved site [IPR018321]", "Glutamate 5-kinase, conserved site [IPR019797]", "Glutamyl-tRNA(Gln) amidotransferase, subunit B, conserved site [IPR017958]", "Glutathione peroxidase conserved site [IPR029760]", "Glycerate/sugar phosphate transporter, conserved site [IPR021159]", "Glycoside hydrolase family 27/36, conserved site [IPR000111]", "Glycoside hydrolase, family 2, conserved site [IPR023230]", "Glycoside hydrolase, family 29, conserved site [IPR018526]", "Glycoside hydrolase, family 35, conserved site [IPR019801]", "Glycosyl hydrolases family 31, conserved site [IPR030459]", "Glyoxalase I, conserved site [IPR018146]", "Golgin subfamily A member 2, C-terminal binding motif [IPR043937]", "Guanine-nucleotide dissociation stimulator, CDC24, conserved site [IPR001331]", "Guanylate kinase, conserved site [IPR020590]", "HIND motif [IPR045347]", "HMG box A DNA-binding domain, conserved site [IPR017967]", "HMG-I/HMG-Y, DNA-binding, conserved site [IPR000637]", "Haem oxygenase conserved site [IPR018207]", "Heat shock protein 70, conserved site [IPR018181]", "Heat shock protein Hsp90, conserved site [IPR019805]", "Helix-hairpin-helix motif [IPR000445]", "Helix-hairpin-helix motif, class 2 [IPR008918]", "Hexapeptide transferase, conserved site [IPR018357]", "Histidine triad, conserved site [IPR019808]", "Histone H2A conserved site [IPR032458]", "Histone H4, conserved site [IPR019809]", "IMP dehydrogenase / GMP reductase, conserved site [IPR015875]", "Immunoglobulin/major histocompatibility complex, conserved site [IPR003006]", "Inositol monophosphatase, conserved site [IPR020550]", "Intermediate filament protein, conserved site [IPR018039]", "Isocitrate/isopropylmalate dehydrogenase, conserved site [IPR019818]", "Kinesin motor domain, conserved site [IPR019821]", "Lipocalin family conserved site [IPR022272]", "Lysophospholipase patatin, conserved site [IPR001423]", "Lysosome-associated membrane glycoprotein, conserved site [IPR018134]", "Macrophage migration inhibitory factor, conserved site [IPR019829]", "Malic enzyme, conserved site [IPR015884]", "Methylthiotransferase, conserved site [IPR020612]", "Mini-chromosome maintenance, conserved site [IPR018525]", "Mitogen-activated protein (MAP) kinase, conserved site [IPR003527]", "Molybdenum cofactor biosynthesis, conserved site [IPR008284]", "Mrp, conserved site [IPR000808]", "Myristoyl-CoA:protein N-myristoyltransferase, conserved site [IPR022678]", "NADH:ubiquinone oxidoreductase, 30kDa subunit, conserved site [IPR020396]", "NADH:ubiquinone oxidoreductase, 49kDa subunit, conserved site [IPR014029]", "NADH:ubiquinone oxidoreductase, 51kDa subunit, conserved site [IPR001949]", "NADH:ubiquinone oxidoreductase, 75kDa subunit, conserved site [IPR000283]", "NADH:ubiquinone oxidoreductase, subunit 1, conserved site [IPR018086]", "NUDIX hydrolase, conserved site [IPR020084]", "Oxysterol-binding protein, conserved site [IPR018494]", "P-type trefoil, conserved site [IPR017957]", "Peptidase M22, conserved site [IPR017860]", "Peptidase M24B, X-Pro dipeptidase/aminopeptidase P, conserved site [IPR001131]", "Peptidase S26A, signal peptidase I, conserved site [IPR019758]", "Peptidyl-prolyl cis-trans isomerase, PpiC-type, conserved site [IPR023058]", "Phosphatidylethanolamine-binding, conserved site [IPR001858]", "Phosphatidylinositol 3/4-kinase, conserved site [IPR018936]", "Phosphoenolpyruvate carboxykinase, GTP-utilising, conserved site [IPR018091]", "Phosphofructokinase, conserved site [IPR015912]", "Phosphoglucose isomerase, conserved site [IPR018189]", "Phosphoglycerate kinase, conserved site [IPR015911]", "Phosphomannose isomerase, type I, conserved site [IPR018050]", "Phosphoribosylglycinamide synthetase, conserved site [IPR020559]", "Phosphorylase pyridoxal-phosphate attachment site [IPR035090]", "Polyamine biosynthesis domain, conserved site [IPR030373]", "Polyprenyl synthetase, conserved site [IPR033749]", "Procollagen-lysine 5-dioxygenase, conserved site [IPR001006]", "Profilin conserved site [IPR027310]", "Proliferating cell nuclear antigen, PCNA, conserved site [IPR022659]", "Proteasome beta-type subunit, conserved site [IPR016050]", "Protein phosphatase 2A regulatory subunit PR55, conserved site [IPR018067]", "Proteinase inhibitor I2, Kunitz, conserved site [IPR020901]", "Proteinase inhibitor I25, cystatin, conserved site [IPR018073]", "Pseudouridine synthase TruD, conserved site [IPR020119]", "Purine phosphorylase, family 2, conserved site [IPR018099]", "Quinone oxidoreductase/zeta-crystallin, conserved site [IPR002364]", "RNA 3'-terminal phosphate cyclase-like, conserved site [IPR020719]", "RNA polymerase, beta subunit, conserved site [IPR007121]", "Ras GTPase-activating protein, conserved site [IPR023152]", "Retro-transposon transporting motif [IPR018892]", "Ribonuclease II/R, conserved site [IPR022966]", "Ribosomal RNA adenine methylase transferase, conserved site [IPR020596]", "Ribosomal S11, conserved site [IPR018102]", "Ribosomal S24e conserved site [IPR018098]", "Ribosomal protein L1, conserved site [IPR023673]", "Ribosomal protein L10e, conserved site [IPR018255]", "Ribosomal protein L11, conserved site [IPR020785]", "Ribosomal protein L13, conserved site [IPR023563]", "Ribosomal protein L13e, conserved site [IPR018256]", "Ribosomal protein L14P, conserved site [IPR019972]", "Ribosomal protein L15, conserved site [IPR001196]", "Ribosomal protein L15e, conserved site [IPR020925]", "Ribosomal protein L18e, conserved site [IPR021132]", "Ribosomal protein L19/L19e conserved site [IPR023638]", "Ribosomal protein L2, conserved site [IPR022671]", "Ribosomal protein L21e, conserved site [IPR018259]", "Ribosomal protein L22/L17, conserved site [IPR018260]", "Ribosomal protein L23/L25, conserved site [IPR001014]", "Ribosomal protein L24/L26, conserved site [IPR005825]", "Ribosomal protein L24e, conserved site [IPR023442]", "Ribosomal protein L27e, conserved site [IPR018262]", "Ribosomal protein L29, conserved site [IPR018254]", "Ribosomal protein L3, conserved site [IPR019926]", "Ribosomal protein L30, conserved site [IPR018038]", "Ribosomal protein L30e, conserved site [IPR022991]", "Ribosomal protein L31e, conserved site [IPR020052]", "Ribosomal protein L32e, conserved site [IPR018263]", "Ribosomal protein L34e, conserved site [IPR018065]", "Ribosomal protein L35Ae, conserved site [IPR018266]", "Ribosomal protein L37e, conserved site [IPR018267]", "Ribosomal protein L4/L1e, eukaryotic/archaeal, conserved site [IPR013000]", "Ribosomal protein L5, conserved site [IPR020929]", "Ribosomal protein L6, conserved site-2 [IPR002359]", "Ribosomal protein L7Ae conserved site [IPR004037]", "Ribosomal protein S13, conserved site [IPR018269]", "Ribosomal protein S17, conserved site [IPR019979]", "Ribosomal protein S17e, conserved site [IPR018273]", "Ribosomal protein S19 conserved site [IPR020934]", "Ribosomal protein S19e, conserved site [IPR018277]", "Ribosomal protein S2, conserved site [IPR018130]", "Ribosomal protein S21e, conserved site [IPR018279]", "Ribosomal protein S3, conserved site [IPR018280]", "Ribosomal protein S3Ae, conserved site [IPR018281]", "Ribosomal protein S4, conserved site [IPR018079]", "Ribosomal protein S4e, N-terminal, conserved site [IPR018199]", "Ribosomal protein S5, N-terminal, conserved site [IPR018192]", "Ribosomal protein S6e, conserved site [IPR018282]", "Ribosomal protein S7, conserved site [IPR020606]", "Ribosomal protein S8e, conserved site [IPR018283]", "Ribosomal protein S9, conserved site [IPR020574]", "Ribosome maturation protein SBDS, conserved site [IPR018023]", "Ribosome-binding factor A, conserved site [IPR020053]", "RidA, conserved site [IPR019897]", "S-adenosyl-L-homocysteine hydrolase, conserved site [IPR020082]", "S-adenosylmethionine synthetase, conserved site [IPR022631]", "S100/Calbindin-D9k, conserved site [IPR001751]", "SAICAR synthetase, conserved site [IPR018236]", "SecY conserved site [IPR030659]", "Serpin, conserved site [IPR023795]", "Short-chain dehydrogenase/reductase, conserved site [IPR020904]", "Sodium:dicarboxylate symporter, conserved site [IPR018107]", "Squalene/phytoene synthase, conserved site [IPR019845]", "Stathmin, conserved site [IPR030514]", "Sterol reductase, conserved site [IPR018083]", "Succinyl-CoA synthetase, beta subunit, conserved site [IPR017866]", "Sulfatase, conserved site [IPR024607]", "Syntaxin/epimorphin, conserved site [IPR006012]", "TPP-binding enzyme, conserved site [IPR000399]", "Terpene synthase, conserved site [IPR002365]", "Tetrahydrofolate dehydrogenase/cyclohydrolase, conserved site [IPR020867]", "Tetraspanin, conserved site [IPR018503]", "Thiolase, conserved site [IPR020613]", "Thioredoxin, conserved site [IPR017937]", "Thiosulphate sulfurtransferase, conserved site [IPR001307]", "Thymidine kinase, conserved site [IPR020633]", "Thymidylate kinase, conserved site [IPR018095]", "Tr-type G domain, conserved site [IPR031157]", "Transcription factor TFIIB, conserved site [IPR023486]", "Translation elongation factor EF1B, beta/delta chains, conserved site [IPR001326]", "Translation elongation factor Ts, conserved site [IPR018101]", "Tubulin, conserved site [IPR017975]", "Tyrosine-protein kinase, receptor class II, conserved site [IPR002011]", "Tyrosine-protein kinase, receptor class V, conserved site [IPR001426]", "UbiE/COQ5 methyltransferase, conserved site [IPR023576]", "Ubiquitin conserved site [IPR019954]", "Ubiquitin interacting motif [IPR003903]", "Ubiquitin specific protease, conserved site [IPR018200]", "Ubiquitin-activating enzyme E1, conserved site [IPR018074]", "Vinculin, conserved site [IPR000633]", "WD40 repeat, conserved site [IPR019775]", "XPG conserved site [IPR019974]", "YgfZ/GcvT conserved site [IPR017703]", "Zinc finger, PHD-type, conserved site [IPR019786]", "Zinc finger, RING-type, conserved site [IPR017907]"], "available_proteins": ["AAAS", "AAMP", "ABCB1", "ABCB10", "ABCB7", "ABCC4", "ABCD3", "ABCE1", "ABCF1", "ABCF2", "ABCF3", "ACAA1", "ACAA2", "ACAD9", "ACADM", "ACADS", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACIN1", "ACLY", "ACSF2", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACSL6", "ACTL6A", "ACTN1", "ACTN4", "ACTR1A", "ACTR2", "ACTR3", "ADH5", "ADK", "ADSL", "AFG3L2", "AHCY", "AHCYL1", "AK1", "AK2", "AK3", "AK4", "AKR1A1", "AKR1B1", "ALDH18A1", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ANXA1", "ANXA11", "ANXA2", "ANXA6", "ANXA7", "AP1M1", "AP1S2", "AP2M1", "AP3M1", "AP3S1", "APEX1", "APP", "ARIH2", "ATAD1", "ATAD2", "ATAD2B", "ATM", "ATP5C1", "ATP5O", "BAG6", "BAZ1A", "BAZ1B", "BAZ2A", "BCAT2", "BCS1L", "BOP1", "BPNT1", "BPTF", "BRD2", "BRD4", "BUD31", "CAD", "CALR", "CAMSAP3", "CANX", "CAP1", "CAPZA1", "CAPZA2", "CAPZB", "CASK", "CBL", "CBR1", "CBX1", "CBX3", "CBX5", "CBX8", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CDC40", "CDH2", "CDK5RAP1", "CDKAL1", "CETN2", "CHAF1B", "CHD1", "CHD1L", "CHD4", "CLGN", "CMPK1", "CNDP2", "COPA", "COPZ1", "CORO1B", "CORO1C", "CPOX", "CRYZ", "CSTB", "CTBP1", "CTBP2", "CTNNA1", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CWC27", "CYP51A1", "DCAF7", "DCP2", "DCXR", "DDT", "DDX10", "DDX17", "DDX18", "DDX20", "DDX23", "DDX24", "DDX27", "DDX31", "DDX3X", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX51", "DDX54", "DDX55", "DDX6", "DHCR7", "DHFR", "DHODH", "DHRS4", "DHRS7", "DHRS7B", "DHX15", "DHX16", "DHX30", "DHX36", "DHX38", "DHX40", "DHX57", "DHX8", "DHX9", "DIDO1", "DIMT1", "DIS3", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJB11", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC2", "DNAJC9", "DNM1L", "DNM2", "DNMT1", "DPY30", "DRG1", "DRG2", "DSC2", "DSG2", "DTYMK", "DYNLL1", "DYNLL2", "EARS2", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "ECT2", "EED", "EEF1A2", "EEF1B2", "EEF1D", "EEF2", "EHHADH", "EIF3I", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4E2", "ENO1", "EP300", "EPB41", "EPB41L2", "EPB41L3", "EPHA7", "EPRS", "ERCC2", "ETFA", "ETFB", "EXO1", "EZR", "FBL", "FDFT1", "FDPS", "FEN1", "FH", "FLNA", "FLNB", "FLNC", "FOXC1", "FUCA1", "FUCA2", "GAA", "GALK1", "GANAB", "GART", "GATB", "GCDH", "GEMIN5", "GFM1", "GLA", "GLB1", "GLO1", "GMPPA", "GMPPB", "GNPDA1", "GNS", "GOLGA2", "GPHN", "GPI", "GPX8", "GRHPR", "GRWD1", "GSPT1", "GTF2B", "GTF3C2", "GUF1", "GUSB", "H2AFX", "H4C1*", "HADH", "HADHA", "HADHB", "HIBADH", "HINT2", "HLA-A", "HLTF", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMOX1", "HMOX2", "HSD17B10", "HSD17B12", "HSD17B4", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA13", "HSPA14", "HSPA1B", "HSPA2", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPD1", "HSPE1", "HSPH1", "HYOU1", "IARS", "IARS2", "IBA57", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDH3G", "IGF1R", "ILVBL", "IMPDH2", "INA", "INTS12", "IQGAP1", "IQGAP2", "IVD", "KDM2A", "KDM5A", "KDSR", "KIF11", "KIF14", "KIF18B", "KIF1A", "KIF20A", "KIF20B", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF4A", "KIF5B", "KIFC1", "LAMP1", "LAMP2", "LARS", "LARS2", "LBR", "LIG1", "LIG3", "LMNA", "LMNB1", "LMNB2", "LSS", "MACF1", "MAPK1", "MAPK3", "MARS", "MAT2A", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "ME1", "ME2", "MIF", "MPI", "MPP1", "MPP2", "MPP5", "MPP6", "MPP7", "MPST", "MRPL13", "MRPL24", "MRPL3", "MRPS11", "MRPS2", "MRPS5", "MRPS9", "MSN", "MTAP", "MTHFD1", "MTHFD1L", "MTHFD2", "MTOR", "MVK", "ND1", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFV1", "NEFL", "NES", "NKTR", "NLE1", "NMT1", "NNT", "NOP2", "NSD1", "NSD2", "NSF", "NTHL1", "NUBP2", "NUBPL", "NUDT1", "NUDT5", "NUP153", "NUP43", "NVL", "OSBP", "OSBPL11", "OSBPL8", "OSBPL9", "OSGEP", "P4HB", "PAFAH1B1", "PAICS", "PAK1IP1", "PBRM1", "PCDH7", "PCK2", "PCNA", "PDIA3", "PDIA4", "PDIA5", "PDIA6", "PEBP1", "PEPD", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGK1", "PGM1", "PGM2", "PGM3", "PHF14", "PHF3", "PHF8", "PHGDH", "PHIP", "PHRF1", "PI4KA", "PIK3C2A", "PIN1", "PLEC", "PLOD1", "PLOD2", "PLOD3", "PLRG1", "PLS1", "PLS3", "PNP", "PNPLA6", "POLA1", "POLD1", "POLR1B", "POLR1C", "POLR2B", "POLR2C", "PPIB", "PPIC", "PPID", "PPIE", "PPIF", "PPIH", "PPIL1", "PPIL2", "PPIL3", "PPP2R2A", "PRKAR1A", "PRKAR2A", "PRKDC", "PRKG1", "PRPF19", "PRPF4", "PSMA4", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PUS7", "PWP1", "PWP2", "PYGB", "PYGL", "QARS", "QDPR", "RACK1", "RAE1", "RANBP2", "RARS", "RARS2", "RBFA", "RCL1", "RDH13", "RDX", "RIDA", "RNF20", "RNF40", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL15", "RPL17", "RPL18", "RPL19", "RPL21", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL37", "RPL4", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPS11", "RPS14", "RPS15", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS21", "RPS24", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS8", "RPS9", "RPSA", "RRP8", "RSF1", "RTCA", "S100A10", "S100A11", "SART1", "SBDS", "SCAF11", "SCP2", "SDHB", "SEC11A", "SEC61A1", "SERPINB6", "SERPINH1", "SLC1A5", "SLC27A3", "SLC27A4", "SLC37A4", "SLC4A2", "SLIT2", "SMARCA4", "SMU1", "SNRNP40", "SNU13", "SORD", "SPATA5", "SPATA5L1", "SPTBN1", "SPTBN2", "SRCAP", "SRM", "STAM", "STMN1", "STX12", "STX18", "STX3", "STX7", "SUCLA2", "SUCLG1", "SUCLG2", "SYNE2", "TAP1", "TBL3", "TCP1", "TFB1M", "THOC6", "TK1", "TLN1", "TMX1", "TMX3", "TMX4", "TOP2A", "TOP2B", "TRIM21", "TRIM24", "TRIM25", "TRIM27", "TRIM28", "TRIM33", "TRIP13", "TRMT11", "TSFM", "TSPAN6", "TST", "TTF2", "TUBB", "TUBB2A", "TUBB2B", "TUBB3", "TUBB4A", "TUBB4B", "TUBB6", "TUFM", "TXN2", "TXNDC12", "TXNDC5", "TXNL1", "UBA1", "UBA2", "UHRF1", "USP10", "USP11", "USP14", "USP15", "USP19", "USP47", "USP48", "USP5", "USP7", "USP8", "USP9X", "UTP15", "UTP18", "UTRN", "VARS1", "VARS2", "VAT1", "VCL", "VCP", "VIM", "VPS4B", "WARS", "WDHD1", "WDR1", "WDR12", "WDR18", "WDR3", "WDR36", "WDR41", "WDR5", "WDR61", "WDR77", "XPNPEP1", "YARS2", "YME1L1", "YWHAB", "YWHAE", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2", "ZMYND8"], "leading_proteins": ["ACBD3", "AHCYL1", "AP3M1", "ATAD2B", "BRD2", "CAPZA2", "CHD1L", "CMPK1", "CTBP1", "CUL1", "CUL2", "CUL5", "DHCR7", "DHX36", "DHX40", "DNM1L", "EEF1A2", "EP300", "FH", "FLNA", "FLNB", "FLNC", "GMPPB", "GSPT1", "HLTF", "HMGB1", "IDH2", "IQGAP1", "KIF14", "KIF4A", "KIF5B", "MPP2", "MVK", "NUBPL", "PCDH7", "PFKL", "PFKP", "PFN1", "PGM3", "PNP", "POLA1", "PPIL2", "PSMB1", "PSMB4", "PSMB5", "PYGB", "SDHB", "SPATA5", "SPTBN2", "TRIM21", "TRIM25", "TRIM33", "TUBB2B", "TUBB3", "UBA2", "USP10", "USP15", "USP19", "USP47", "USP5", "USP7", "USP9X", "UTRN", "YWHAB"]}
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{"0": "SH3 domain [IPR001452]", "1": "Importin-beta, N-terminal domain [IPR001494]", "2": "Proteasome component (PCI) domain [IPR000717]", "3": "Protein kinase domain [IPR000719]", "4": "Zinc finger, RING-type [IPR001841]", "5": "TOG domain [IPR034085]", "6": "Peptidase C19, ubiquitin carboxyl-terminal hydrolase [IPR001394]", "7": "Ubiquitin specific protease domain [IPR028889]", "8": "Clathrin/coatomer adaptor, adaptin-like, N-terminal [IPR002553]", "9": "Pleckstrin homology domain [IPR001849]", "10": "Gelsolin-like domain [IPR007123]", "11": "MPN domain [IPR037518]", "12": "Helicase, C-terminal [IPR001650]", "13": "Helicase superfamily 1/2, ATP-binding domain [IPR014001]", "14": "K Homology domain, type 1 [IPR004088]", "15": "Ubiquitin-conjugating enzyme E2 [IPR000608]", "16": "K Homology domain [IPR004087]", "17": "W2 domain [IPR003307]", "18": "Zinc finger C2H2-type [IPR013087]", "19": "RNA recognition motif domain [IPR000504]", "20": "DnaJ domain [IPR001623]", "21": "Translational (tr)-type GTP-binding domain [IPR000795]", "22": "AAA ATPase, AAA+ lid domain [IPR041569]", "23": "Calponin homology domain [IPR001715]", "24": "PDZ domain [IPR001478]", "25": "AAA+ ATPase domain [IPR003593]", "26": "von Willebrand factor, type A [IPR002035]", "27": "ATPase, AAA-type, core [IPR003959]", "28": "DEAD/DEAH box helicase domain [IPR011545]"}
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